Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reader, Author, Scholar in a Context of Information Overflow. How to master and manage knowledge when there is too much to know? (RASCIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-15
End date: 2021-05-24
Duration (months): 29.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The Mamluk period (1250-1517) is an example in terms of intellectual vivacity. Scholars and books travel easily, ideas are extensively discussed and shared, and the sum of knowledge available is always increasing. When it is no longer possible to master all the knowledge alone, and by heart, how do scholars compose new books? To answer this question, an eminent scholar of this time, al-Ṣafadī (d. 1363), will be taken as example. Several volumes of his personal reading journal—“tadhkirah”—are preserved, but have never been studied. They constitute exceptional evidence of his reading activity and reflect the very first stage of his working method. Besides, several manuscripts that were part of al-Ṣafadī’s personal library are preserved. Tracking them and the marginalia that al-Ṣafadī added next to their text sheds a complementary light on his readings. The only holograph volume of al-Ṣafadī’s tadhkirah preserved will be subject to a thorough and comprehensive study. All the authors and works cited will be identified, al-Ṣafadī’s excerpts will be confronted to the original texts. When the actual manuscript al-Ṣafadī read is identified, a careful analysis of the latter is conducted (study of paratexts left by al-Ṣafadī in the course of his work, codicological analysis). Moreover, the way al-Ṣafadī used the excerpts in his own works will be studied as well. An Open Access online edition will be prepared, including links to the original texts cited, to biographies of the authors, to al-Ṣafadī’s works using these information, and to the online database ELEO (database of paratextual elements). Such exceptional documents will provide us an innovative picture of intellectual life during the Mamluk period, a period similar to ours in terms of overabundance of information. Therefore, the study of this original subject is perfectly timely—it will fill the gap of our knowledge of intellectual history of the Mamluk period and will nourrish our perceptions about our times.

Keywords: arabic manuscripts,arabic literature,codicology,archaeology of the book
Platform for Rapid Development of Personalized Nanomedicine Drug Delivery Systems (PACE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Cyprus,Serbia
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 99312.5
EU funding (EUR): 99312.5
Participants: 2
Project status: CLOSED

Innovation idea of the proposal is to create a standalone personalized-medicine computational platform that use patient-specific tumour parameters to recommend nanomedicine-based drug delivery systems which would be the most optimal to treat specific patient. It will be done by using a computational platform that is under development in the ongoing FET Open project EVO-NANO. The core of PACE will be to develop IP in EVO-NANO in accordance to market and regulatory demands thus increasing both the technology readiness level (TRL) as well as the investment readiness level (IRL). The ultimate objective will be to position IP from EVO-NANO for market uptake through the completion of exhaustive commercial due diligence which will create the market strategy from gathered market research. The project will consist of several stages that are organized so that each step further funnels the research down to ever greater levels of focus. Stages are: 1- Ideation, IP / Business Model Preliminary Research and Positioning; 2 -Market Research, which is divided into two sub-stages: 2A – Macro Market Research and Analysis, and 2B – Application Research and Analysis; 3- Market Strategy; and 4- Exploitation. The impact of this proposal will be the creation of monetarily valuable IP and/or the foundation for the creation of a business that can create monetary value. Although the ongoing FET Open project EVO-NANO will have social impact toward treating cancer, PACE is aimed at gathering the necessary market information to position EVO-NANO for market uptake. In other words, these projects will increase the competiveness of European SMEs while contributing/supporting European industrial leadership in nano-personalized medicine technologies. The dissemination of PACE will go beyond simply broadcasting the IP and will be specifically aimed at targeting the audience decided upon in the market research stage.

Keywords: nanomedicine,cancer,tumor
Wavefunctions for strongly correlated systems (WASCOSYS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-06-30
Duration (months): 64.0
Total project cost (EUR): 1338500.0
EU funding (EUR): 1338500.0
Participants: 2
Project status: CLOSED

Strongly correlated quantum systems, which are at the heart of many open problems in condensed matter, quantum chemistry, or high-energy physics, are challenging to understand due to their intricate entanglement structure. Quantum information theory provides the right framework to characterize highly entangled states and has given rise to the class of Tensor Network States, which capture the entanglement structure of strongly correlated systems by building the global wavefunction from local tensors and provide an efficient description of their low-energy states. In this project, we will develop a framework for the systematic study of strongly correlated systems using exact wavefunctions based on Tensor Network States. It will give us the tools to construct controlled families of states by encoding the relevant structure of the system directly into the wavefunction, rather than a Hamiltonian, and to study their behavior. Since the tensor describing the wavefunction also gives rise to an associated Hamiltonian, this establishes a framework for building solvable models with the tensor as the new central object. The novelty of our approach lies in the fact that quantum information gives us the tools to systematically construct wavefunctions for general strongly correlated systems, while at the same time, encoding the structure of the problem directly into the wavefunction results in small families of states with a direct physical interpretation of the parameters, unlike for fully variational approaches. We will apply our framework to study the physics of a range of strongly correlated models, in particular frustrated fermionic and spin systems, in order to understand the possible physics they can exhibit. This will enhance our understanding of the physics of strongly correlated systems, and, together with numerical results, experimental findings, and quantum simulations, ultimately lead to new applications and materials based on strongly correlated matter.

Keywords: many body entanglement theory,strongly correlated systems,tensor network methods
For a better understanding and design of ferroelectric photovoltaics: First-principles study of optical absorption and charge-carrier transport at ferroelectric domain walls in BiFeO3 (FERROVOLT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-15
End date: 2019-06-14
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The goal of this project is to help find the rules for a domain-wall engineering that optimizes photovoltaic efficiency of potential future-generation ferroelectric solar cells. The material to be studied is BiFeO3 as the most promising photovoltaic ferroelectric material known. Does the photovoltaic effect in BiFeO3 occur at the domain walls or in the bulk? What does it take a domain-wall to conduct electrons? The project aims at establishing the necessary conditions for electric fields and electrical conductivity at ferroelectric domain walls. Since experimental evidence is inconclusive, state-of-the-art ab initio methods will be applied. Electric fields have a long spatial range, so we will go beyond the standard supercell approach to obtain the spatial gradient of the band structure at the domain wall, needed to obtain charge-carrier distributions and electric fields. The Green's-function method for electronic quantum transport will be used for this purpose because it is suitable for extended, non-periodic systems. We will obtain the electrical conductivity as a function of the domain-wall type, structure, and purity. Conclusions for the role of the domain walls in BiFeO3 will be generalized as far as possible in order to apply them to other ferroelectric semiconductors as well. The applicant will receive training in state-of-the-art electronic-transport calculations by the host. In turn, the applicant will strengthen the host’s activities in the field of modelling optical properties of semiconductors. The project is positioned where fundamental condensed-matter physics meets applied solar-cell research. It is expected to advance the frontier of knowledge in basic research and to lay the ground for further research on ferroelectric photovoltaics. It is a contribution to the efforts of the European Union to develop innovative solutions for a sustainable energy supply that help achieve independence of fossil energy.

Keywords: ferroelectrics,domain walls,perovskites,photovoltaics,electronic transport,first principles,density functional theory,many body perturbation theory
Entropically programmable DNA-based bioSensors for personalized medicine (Entropic DNA Sensors)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

My proposed program consists in a 2-year research activity at the forefront of bioengineering, aiming at the development of Entropically programmable DNA-based bioSensors for high-precision medicine (Entropic DNA Sensors). Biosensors have achieved a significant feat in bioanalytical chemistry and translational science: high-frequency, real-time and quantitative measurements of clinically relevant molecules in vitro, and in vivo. Despite their advantages, our ability to precisely control and regulate the binding activity of their bioreceptors (i.e., the recognition element) still represents a highly relevant bioengineering challenge and limitation. Indeed, the fully control of bioreceptor’s binding properties would allow the design of new biosensors with improved and predictable analytical performance. In Entropic DNA Sensors I propose a multidisciplinary, innovative, and versatile approach based on a purely naturally inspired entropic allostery mechanism which allows to finely tune the activity and the response of synthetic bioreceptors. Specifically, my goal is to further explore our ability to rationally design intrinsically disordered domains into classic DNA-based bioreceptors so as to improve their useful dynamic range. Then, I will adapt these intrinsically disordered bioreceptors into an electrochemical read-out modality that supports the real-time, multi-hour, high-frequency, calibration-free measurements of clinically relevant molecules (i.e., doxorubicin, glucose, phenylalanie) directly in complex biological fluids in vitro. Finally, I will test them in simulated clinical scenarios to demonstrate their ability to reach personalized medicine. To achieve this goal I will leverage my experience in In vivo biosensing and Point-of-care (PoC) testing technologies with the recognized expertise in Functional DNA nanotechnology and Synthetic biology of Prof. Francesco Ricci at University of Rome Tor Vergata (UNITOV-Rome, Italy).

Keywords: structure switching receptors,intrinsically disordered domains,electrochemical biosensors,electrochemical dna sensors,reagentless biosensors,aptamers
New breast cancer therapies based on available p38 MAPK inhibitors (p38Cure)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 149995.0
EU funding (EUR): 149995.0
Participants: 1
Project status: CLOSED

Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative/basal-like and HER2+. Since luminal A tumors tend to be ER+, their treatment often includes hormonal therapy. HER2+ tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tumors, which are ER- and HER2-, and these are usually treated with a combination of surgery, radiotherapy and chemotherapy. There is an urgent need for new therapies to effectively treat different breast cancer subtypes. Translating basic knowledge on tumor cell biology into more effective diagnostic tools and improved treatments for patients remains difficult. The use of patient-derived xenografts (PDX) as preclinical models that recapitulate the complexity and heterogeneity of the human tumors should help to develop and successfully translate to the clinic new therapies. Our recent work provides genetic and pharmacological evidence showing that p38 MAPK inhibition cooperates with the chemotherapeutic agent cisplatin to reduce breast tumor size and malignancy in vivo. Our results support a potential therapeutic use for p38 MAPK inhibitors in combination with chemotherapeutic drugs. The idea is to use PDX of specific breast cancer subtypes for preclinical validation of a new drug combination therapy with potential benefit to patients, which can be confirmed in clinical trials.

Keywords: breast cancer therapy
Fostering local energy investments in the Province of Matera (FESTA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Italy,Italy
Call: Project development assistance for innovative bankable and aggregated sustainable energy investment schemes and projects (H2020-EE-2014-4-PDA, 2014)
Start date: 2015-03-01
End date: 2022-01-31
Duration (months): 83.0
Total project cost (EUR): 498157.0
EU funding (EUR): 498157.0
Participants: 3
Project status: CLOSED

FESTA has the overall objective to foster local energy investments on public buildings (primarily in schools, a significant target in Italy for energy efficiency) and to spread the PPP approach also through the innovative, for the context, Energy Performance Contracts (EPC) in convergence regions. The main specific objectives of the proposed action are: 1. to define technical, financial, legal and administrative specifications of a package of investments that are economically sustainable and attractive for private investors; 2. to assess a PPP scheme and to define an EPC model for the energy efficiency of public buildings, also to create better condition to renewal this aged (> 30 years) buildings; 3. to publish the call for tender and to procure the bundled investments through EPC and sign the investment contracts; 4. to become a best practice for the mobilisation of local energy investments of the area where municipalities are preparing the SEAPs (Province of Matera – leader of this project – is the coordinator); 5. to share all this advances with local actors and other MLEI European partners. Specifically, the project (regarding a complex of schools in Matera and in Policoro with the neighboring hospital) aims to experiment, with technological and method approaches, the achievement of the objective that all schools in the area become “climate neutral” by 2020. The project also aim to generate capacity building in the field of renewable energy and energy saving through: • the inter-institutional collaboration between different public authorities to increase the interventions scale (that is very important considering both the small average size of the local administrations and the low population density); • the development of approaches that pay special attention to the potential of the PPP in the field of energy; • better understanding of the features that this kind of projects should have in order to be attractive to both lenders and ESCOs.

Keywords: public private partnership,energy performance contracts,bundled bankable investments
Innovative diagnostic device for the early detection of diabetic neuropathy in diabetes patients (INNODIAB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the innovation project is to develop and clinically validate the first diagnostic device for the early detection of diabetic neuropathy (also referred to as diabetic foot). Diabetic foot is a common complication of both type 1 and type 2 diabetes. Current methods are only able to detect diabetic foot once the patient is already experiencing loss of sensation. This can result in an increased number of amputations and costs as a result of those amputations. The disruptiveness and the market potential of the new device lie in its capacity to identify diabetic neuropathy at a very early stage. The device will fill the identified niche on the market and contribute to better clinical outcomes for the patients. The main need of the users (physicians, nurses, policy makes, and patients) is access to an efficient dependable method for early detection of diabetic neuropathy. These needs will be met through the prototype device allowing physicians and nurses to assess the condition and determine appropriate treatment. The Phase 1 project will develop a strategic business plan for the commercialisation of the innovative diagnostic device for the early detection of diabetic neuropathy. The project will strengthen VibroSense’s understanding of the European market in general and verify the economic viability of the clinical validation to be pursued within the Phase 2 project. The late diagnosis of diabetic foot results in patient’s suffering and substantial health-care costs. It is estimated that approximately 1/9 of the total healthcare expenditures in Europe is spent on diabetes, with foot care being one of the more dominant costs. The project addresses this EU-wide challenge by proposing a new early-diagnostic method. The new device will build a strong case for introducing more cost-effective, personalised medicine approaches in the management of diabetic foot. The commercial output will be new competitive advantages and accelerated growth for VibroSense.

Keywords: diabetic neuropathy,diabetic foot,peripheral neuropathy,early detection of diabetic foot,vibrometry
IRB DoctoRal fEllowship ProgrAMme: attracting international talent (IRB_DREAM) (IRB_DREAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2169600.0
EU funding (EUR): 1084800.0
Participants: 1
Project status: SIGNED

IRB Barcelona is a world-class research centre conducting multidisciplinary research of excellence at the unique interface between biology, chemistry and medicine and devoted to understanding fundamental questions about human health and disease. One of the main missions of the Institute is to provide young life scientists with the opportunity to train and conduct research in a unique and multidisciplinary scientific environment. IRB_DREAM is an innovative initiative that will offer 10 four-year fellowships in two separate calls to young and talented researchers to undertake their PhD theses in one of the 27 laboratories at IRB Barcelona. IRB_DREAM seeks to revamp IRB Barcelona’s current PhD Programme by adding an innovative dimension, namely the customization of both the training offer and career development, to its already recognised excellence in research. To implement this enhanced training approach, IRB_DREAM not only counts on a unique training offer carefully designed to promote the 3i aspect but it particularly fosters much valued secondments and other initiatives aimed at enhancing the impact of the results and the career prospects of candidates beyond academia. In this regard, the objectives of IRB_DREAM are fully aligned with IRB Barcelona´s mid-term strategic objectives: to enhance the international visibility of the Institute, to boost translational research by devoting resources to new collaborations with hospitals, and to continue promoting knowledge and new technology transfer to the industrial sector. Fellows will be selected through an independent committee of experts, thereby ensuring transparency and equal treatment of all applications. All of IRB Barcelona’s research programmes will be open to applications from IRB_DREAM fellows. The IRB_DREAM programme will specifically bolster the career development of highly talented scientists and strengthen the biomedical sciences in general.

Keywords: predoctoral training,career development,research of excellence,mentoring and supervision,3i dimension