Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Casting light on HOst-cytomegaloviRUs interaction in Solid organ transplantation (HORUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Germany,Netherlands,Italy,Spain,Switzerland,Czechia,Belgium
Call: Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2) (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 7136104.43
EU funding (EUR): 7136102.68
Participants: 24
Project status: SIGNED

Solid organ transplantation (SOT) is the treatment of choice for end-stage organ failure but the immunosuppressive drugs used to prevent graft rejection expose to an increased risk of opportunistic infections among which CMV disease leads to the most frequent morbidity and even mortality. HORUS project gathers solid-organ transplantation experts, computational data scientists, virologists and immunologists in a fully operating European network including 25 partners. HORUS ambitious but realistic goals is to improve our understanding of CMV/host interactions in the context of immunosuppression, with a particular focus on i) the characterization of signatures associated with the control of CMV replication after transplantation, ii) the characterization of signatures associated with the evolution toward a difficult-to-treat CMV disease and poor outcome during CMV replication, iii) the discovery of new specific immunomodulatory molecules promoting CMV control while maintaining prevention of acute rejection. HORUS includes the constitution of the first European SOT recipient longitudinal cohort. In a sub- “HORUS-exploratory cohort”, we will perform a deep investigation of viral, clinical and immunological characteristics. Combining those parameters will provide a signature early after transplantation to predict the risk of developing CMV infection and a signature at day 0 of infection to predict the risk of CMV disease severity. This signature will next be validated retrospectively on the whole cohort and prospectively in a “proof-of-concept" study. Moreover, HORUS will include functional in vitro and mice models to understand the mechanisms of lymphocyte response to CMV and provide innovative methods to increase CMV-specific immunity. Altogether, HORUS will lead to personalized clinical prevention and treatment of CMV disease and to improvement of patient outcomes.

Keywords: cytomegalovirus,immunosuppression,solid organ transplantation
timing FEstivals with Archaeology and Skyscape at Greek Temples (FEAST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 2
Project status: SIGNED

FEAST action will investigate the timing for the main celebration at Greek temples. The project attempts to overcome a gap in the current knowledge on the archaeology of Greek sanctuaries (specifically for the Magna Graecia) by applying an interdisciplinary approach to classical archaeology, that is skyscape archaeology. For most of Magna Graecia temples, there are no indication about when, in the year, the main celebration would have taken place. There, the epigraphical, historical, and archaeological evidence is very lacunose for the topic of festivals and calendars. Therefore, the method here proposed interlinks archaeology with astronomy, researching about the way ancient sanctuaries were built, by analysing the actual orientation that the founders gave to the monument during its foundation in relation to the sky. Temples will be surveyed according to standard topographical methods, with specific attention to the superimposition of strata and the diachrony of the phases of attendance. This research will focus on a chronological horizon that goes from the 8th to the 3rd century B.C., a broad spectrum which allows to discern any continuity and discontinuity in the topography of the sacred. In line with Europe priorities for an inclusive, green and sustainable development, FEAST action fit in the modern challenge of recovering the deep/intimate connection between people and the planet/the sky, while tackling most pressing global challenges of identity crisis of people/nations, focusing on the festivals as moments of community memory and identity building and on heritage sites as places of belonging (coherently with The New European Bauhaus EU mission). The fellowship at the Laboratory of Archaeometry at UOP would open up Dr. Cristofaro career by establishing the applicant as one of the few experts in the world in Skyscape Archaeology of the Classical World, as well as will enhance LA@UOP's international excellence in Archaeometry by adding a new field of expertise.

Keywords: archaeoastronomy,skyscape archaeology,archaeology of cult,topography,landscape archaeology
PANDa - Portable Multi-ANalyzer for the Detection of metals in water (PANDa)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2025-04-30
Duration (months): 30.0
Total project cost (EUR): 2846500.0
EU funding (EUR): 1992550.0
Participants: 1
Project status: SIGNED

Klearia enables real time control for efficient treatment management and good quality water. We develop and produce advanced electrochemical multi-element water analysers based on our patented microfluidics chips LabInGlass®. There is a high demand for testing technologies capable of detecting, identifying and quantifying heavy metal elements in water with precision and promptness for immediate response. After the successful commercialization of an arsenic analyser, Klearia has developed PANDa, the first plug-and-play portable analyser of metal micropollutants at ultra-low concentrations. PANDa allows detection and quantification with very small samples with the same reliability than in a lab in 30 minutes to 2 hours, thereby making immediate response possible. Sample pre-treatment, equipment calibration and detection electrodes cleaning are automated, and the analyses can be performed anywhere, without specific training. We expect cumulative revenues of 47 M € until 2029.

Keywords: heavy metals,environmental protection,chemical engineering,technical chemistry,lab on chip,microfluidics,micropollutants,water analysis,detection technology
Exploring the mechanisms of long-term tumour evolution and genomic instability in marine transmissible cancers (CellFish)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2497364.0
EU funding (EUR): 2497364.0
Participants: 1
Project status: SIGNED

Cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme. Most cancers arise from and remain within the bodies of their respective host individuals. Rarely, however, cancers may escape their hosts to become ‘transmissible cancers’, infectious cell lineages that spread between individuals by direct transfer of cancer cells. As parasitic cancers capable of surviving for millennia, transmissible cancers offer a unique model for exploring how mutation, selection and cellular processes mould and constrain selfish tumour evolution. Marine bivalves (shellfish including clams, mussels and cockles) are affected by at least 10 transmissible cancers, which spread via waterborne cell transfer. The recurrent emergence of long-lived cancers in shellfish provides a valuable resource for comparative studies aiming to probe the basic mechanisms of tumour evolution, including extreme genomic instability. Yet, the evolutionary histories of these cancers are poorly understood. My vision is to elucidate the origins and evolution of marine transmissible cancers by conducting a large-scale comparative genomic study of these cancers. My aims are to: 1. Understand how transmissible cancers arise, mutate and spread under the sea 2. Identify the mechanisms and consequences of genomic instability in transmissible cancers. My research approach will involve: - Extensive tumour sampling across continents - Generation of high-quality bivalve genome assemblies - Application of state-of-the-art technologies, including laser microdissection and single-cell sequencing, to hundreds of tumours - Development of specialised methods for comparative cancer genome analysis. The intrinsic heterogeneity and short lifespans of most cancers may obscure their underlying biological patterns. By examining the convergent evolution of 10 long-lived cancers through a comparative-genomics lens, I intend to deliver fundamental insights into cancer biology and evolution.

Keywords: transmissible cancer,cancer genomics,comparative genomics,genomic instability
human pluripotent stem cell registry - hPSCreg (hPSCreg)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Coordination and support actions
Countries involved: Germany
Call: European registry for human pluripotent stem cell lines (HORIZON-HLTH-2021-hPSC-09-IBA, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1499317.5
EU funding (EUR): 1499317.5
Participants: 1
Project status: SIGNED

The human pluripotent stem cell registry (hPSCreg) is providing validated information about human embryonic stem cells (ESC) and other human pluripotent stem cells (PSC) such as induced PSC. This information is linked through an unique persistent identifier and it includes data on ethical provenance and scientific quality, cell line application and clinical studies performed with hPSC. The open access Registry acts globally to provide a transparent resource and tool for PSC, to maximize cell utility, reproducibility and benefit and minimize research, ethical and regulatory risks. It validates and certifies the registered cell lines based on the provided documents, data and information, assuring high quality of certified lines. hPSCreg is involved in multiple EU-Projects, international consortia and organizations to provide information, data standards and support dissemination. The main task of hPSCcreg within this project proposal are to maintain and improve its function as a centralized registry of hESC and hiPSC lines allowing for (i) transparent validation and monitoring of the ethical and scientific developments in the field; (ii) transparent data – based certification of PSC to assure and maintain highest quality; (iii) implementing FAIR data standards and a continuously improved data reliability in downstream stem cell research; (iv) supporting academic, industrial and clinical research on PSCs and maximizing their potential; and (v) inclusion of diverse stakeholders in the communication process on emerging PSC - based technologies, including research towards clinical applications.

Keywords: pluripotent stem cells,database,data management,stem cell registry,ethics
Charting Female Property and Patrimonial Rights in Law and Practice Across Western Europe (12th-16th Centuries) (PatriFem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1960215.0
EU funding (EUR): 1960215.0
Participants: 1
Project status: SIGNED

From the mid-12th century, all over Europe, laws started to be enacted that hindered women from acquiring and managing wealth, triggering a long process that on the threshold of early modernity led to a dramatic reduction in their economic opportunities. The importance of the issue is undeniable, not only because female agency has been a central theme in gender studies, but also because the effects of these developments are still felt today, yet the underpinnings of these developments are far from clear. The period which is being taken into consideration coincides with a foundational phase of contemporary Europe which saw profound economic, social and political transformations, changes in family structures, and complex legal developments. So why certain laws began to be enacted at this precise moment? How is the cutback in female economic rights connected to the late medieval developments? To what extent and how did female economic rights vary from one context to another? The aim PatriFem is to provide answers to these crucial questions through an innovative and extensive research covering three regions with extremely diverse characteristics in terms of legal traditions, and socio-economic and political frameworks: Italy, France, and the German-speaking area. Research will involve the collection and management of large data sets. It will be carried out in different archives across Europe using two main bodies of sources: statutes (to chart the developments in property and patrimonial rights) and private sources (eg. notarial records, to observe how laws were interpreted or even preempted in practice). The methodology, which can be adopted for different areas across time, will be instrumental to future research. The data will enable to develop an interactive digital atlas which will represent an unprecedented attempt at charting a chronological geography of female property and patrimonial rights in law and practice across Europe over the span of five centuries.

Keywords: female economic rights,female agency,dowries,non dotal assets,inheritance practices,female property and patrimonies
Rapid and Affordable Microbiology test for the Prediction of Undesirable biocontaminations at the Point of need (RAMP-UP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Unwanted microbes cause 14 M human deaths annually worldwide and spoil up to 25% of food and beverage production. The current approach to combat these biohazards focuses on detection and treatment once symptoms are visible and deleterious effects have already appeared. This leads to massive treatments which contribute to the rise of antimicrobial resistance, with over 40% of infections now caused by resistant microbes. Being able to predict the risk of biohazardous situations would allow for timely and more gentle preventive actions. Unfortunately, microbes with varying biohazard potential often coexist in contaminated environments while only the subpopulation of active microbes poses a real risk. However, as no existing tool can discriminate this subpopulation, prediction of microbial behavior and treatment efficacy remains challenging. To address this need, BforCure has developed a Rapid and Affordable Microbiology test for the Prediction of Undesired biocontaminations at the Point of need. This solution relies on the measurement of two universal biomarkers with BforCure’s novel proprietary Molecular Petri Dish technology, to assess the viability and growth potential of microbial subpopulations at the single-cell level within 10 minutes, and model their evolution. This approach allows for the prediction of biohazardous situations and evaluation of mitigation measures' effectiveness. BforCure is asking for the support of the EIC to finalize the development and industrialization of this solution, targeting two markets sequentially: the prevention of spoilage in fermented beverages and waterborne contaminations, valued at €200M and €2B, respectively. These markets are growing rapidly due to climate change, new regulations, and evolving customer requirements. With its prior art solutions, skilled human resources, and extensive assets, BforCure is well-positioned to be a first mover in these markets, and to significantly impact the prevention of microbial biohazards.

Keywords: prevention of fermented beverage spoilage,prevention of waterborne biocontamination,molecular petri dish
Arc Fault Detection, low EMI and Reliability for Power Electronics in Electric Aircrafts (POWER4AIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Research and Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Spain,France,Germany,Norway
Call: Advanced Concepts for Reliable Power Electronics Conversion and Distribution in Aviation (HORIZON-JU-Clean-Aviation-2025-01F, 2025)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 4998233.75
EU funding (EUR): 4998233.75
Participants: 9
Project status: SIGNED

The objective of POWER4AIR is to mature relevant technologies for electronic power conversion in the aeronautical field. HVDC power distribution and aerospace standards impose specific requirements on this type of equipment when used in commercial aviation. Additionally, these technologies can be applied to other fields as well. The main technologies to be matured are: Reliability Models of Power Modules: Current reliability models rely on knowledge from silicon devices. However, recent WBG devices such as SiC or GaN do not have accurate reliability models. This drawback increases the maintenance costs of power conversion equipment, hindering a smooth EIS by 2030. AFD and PD Detection: The voltage increase to HVDC in electrical distribution aims to minimize wire section and weight but also increases the risks of arcs through the EWIS of the aircraft. Therefore, it is of utmost importance for the safety of the system to quickly identify these events and take appropriate actions to prevent chained failures. High-Density Filters: Power converters are intrinsically electromagnetically noisy due to high dv/dt transitions at semiconductors. To comply with current EMI (Electromagnetic Interference) and power quality requirements in commercial aircraft, bulky filters are typically used to reduce the noise. In POWER4AIR, active filtering will be explored to reduce the size and weight of these filters. High-Density Magnetics: Another option to reduce the size and weight of electronic power conversion equipment is to improve the magnetic elements of the converters by design. This involves using new materials or improving the thermal performance of magnetic elements, such as coils, transformers, or chokes. Demonstration at Converter Level: Finally, these technologies will be integrated into a 200kW power converter and demonstrated against relevant performance metrics in aeronautical applications.

Keywords: clean aviation,sic,power electronics,arc fault detection,partial discharge,health monitoring,electrification,aircraft
Development of Perovskite Photovoltaics for Space Environment (P4SPACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 207609.6
EU funding (EUR): 207609.6
Participants: 2
Project status: CLOSED

Hybrid organic-inorganic perovskite solar cells (PSCs) as a well-known emerging thin-film photovoltaic (PV) technology are developing rapidly owing to their versatile optoelectronic properties. Outstanding photoconversion efficiency, high specific power (power to weight ratio), compatibility with flexible substrates and low-cost chemical-based manufacturing, and excellent radiation resistance of PSCs make them as a promising alternative for next-generation space PVs. However, compared with other practical space PVs, such as silicon and III-V multi-junction commercial cells, the research on PSCs for space environment is just in the infancy stage. The aim of P4SPACE project, is delivering of a sustainable PV technology for any present and future space environment application by developing and scale-up of the PSCs with high performance and durability in the harsh space environments.

Keywords: perovskite solar cells,space environment,stability,modules,low cost manufacturing,up scaling,thin film photovoltaics,emerging thin film pvs,sustainability