Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generation of safe and efficient, off-the-shelf, chimeric antigen receptor (CAR)-engineered T cells for broad application (CARiPSCTcells)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 165598.81
EU funding (EUR): 165598.8
Participants: 2
Project status: CLOSED

The feasibility and effectiveness of adoptive T cell therapies for cancer has now been proven in several clinical settings. Yet, the current approaches are still “individual-tailored” and thus, their progress and broader use is limited. Having rapid access to “off-the-shelf”, safe cellular products, which can be applied across histocompatibility limitations, would greatly benefit the broader applicability of adoptive T cell therapy. To this end, the applicant recently reported, in a proof-of-concept study, that genetic engineering of T-cell derived induced pluripotent stem cells (TiPSC) with Chimeric Antigen Receptors (CARs) can be an efficient strategy to concomitantly harness the unlimited availability of induced pluripotent stem cells and direct the specificity and functional potential of TiPSC-derived T cells in an HLA-independent manner. Based on this technology, this proposal aims to further investigate novel stem cell genetic engineering strategies in order to obtain in vitro, unlimited, safe and broadly applicable T cells targeting Multiple Myeloma (MM). We propose to target MM with a novel CD38-targeting CAR (CD38CAR). Since CD38 is not a MM-specific target, we aim to simultaneously tackle the on-target/off-tumor toxicity by introducing a drug-regulated expression of CD38CAR. In addition, we aim to use the CRISPR/Cas9 system to achieve targeted knockout of the endogenous T cell receptor (TCR) and the HLA antigens on the CAR-engineered TiPSCs (CARTiPSC) in order to extend the applicability of CARTiPSC-derived T cells across HLA-barriers. The success of this proposal will lay the foundation for further translational application of CARTiPSC-derived T cells cells and investigation of new strategies to enhance their effector function and persistence.

Keywords: chimeric antigen receptor,induced pluripotent stem cells,adoptive t cell therapy
Next generation technologies for modeling the full complexity of living and designed structures (NGTMod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 119901.6
EU funding (EUR): 119901.6
Participants: 2
Project status: CLOSED

The goal of the NGTMod project is to define the next generation technologies for modeling the full complexity of living and designed structures. The need to describe and handle complex geometrical objects is present in many different domains of application such as medical imaging, geology, material analysis, etc. In all these domains, we seek to describe very complex objects, in order to obtain a description of objects with a very high level of precision, and/or to describe very large objects. In both cases, the goal is to obtain a very precise representation, making it possible to define several high level operations to create and modify the objects. Many works have proposed very advanced solutions for specific cases. Most of them deal with 2D and 3D regular subdivisions which are in no way generic, and the few existing generic solutions do not allow us to describe very complex objects. Our goal in this project is to propose a general purpose representation for geometric structures of arbitrary topology, making it possible to describe and handle very complex objects. To achieve this goal, we will take advantage of Jarek Rossignac's wide experience of computer graphics and compact data structures during the outgoing phase in Georgia Tech University, while providing our major knowledge of cellular data structures, generic operations and their implementation in software libraries. We will transfer the acquired skills and knowledge during the return phase by working with Florent Dupont of Lyon 1 University who is an expert on image and mesh processing and analysis and this phase will benefit from the new generic data structure and high level operations.

Keywords: computer graphics,geometric description,generic subdivision,complex objects,compact data,structure,high level efficient operations,free software development
BIRDWATCH, The first integral and modular mobility and security solution for smart parking management (BIRDWATCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BIRDWATCH PARKING SUITE is a new innovative solution that offers a global management system of car parks outdoor and indoor.BirdWatch Parking Suite solution is based on a combination between advanced license plate recognition techniques, digital video recording, non-intrusive vehicle presence detection and technologies that detect people and vehicles movement. Moving the market beyond the state of the art, the innovation degree of our solution is given by the high reliability of the technologies used and on the fact that the whole management is based on the idea of linking a vehicle (identified by its plate number) with all that happens to it during its staying in the car park. BirdWatch ParkingSuite has a high degree of user-friendliness and is targeted to all car owners who use a public or private space for temporary parking their car. BirdWatch benefits drivers, car park managers and city decision makers. BirdWatch will provide drivers with an improved parking experience, car park operators with a comprehensive tool to easily effectively manage all mobility, security and payment issues in a parking, and city policy makers will have the necessary information to improve the urban transportation system and traffic flow. BirdWatch will also contribute to reduce pollution, fuel waste and stress thus providing environmental and economic benefits to the cities. The feasibility study Quercus intends to conduct will assess which markets are more inclined to accept the solution and will evaluate if our initial marketing plan is realistic and could be effectively implemented. Quercus is a high-technology international SME based in Spain, Europe that has been present on the ITS market for 15 years and specialises in Computer Vision technologies. Quercus products are being sold and installed in Europe, North and South America, the Middle East and Africa. BirdWatch is Quercus’ core project for future geographical and commercial expansion.

Keywords: integrated solution,computer vision,smart parking management,transport,environmental defies,mobility defies,disruptive innovation,european and global markets,smart cities
CROR Blade-Out Impact Simulations and Sample Manufacturing (BLADEOUT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Greece,Greece
Call: Blade FEM impact simulations and sample manufacturing for CROR Aircraft (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 344227.5
EU funding (EUR): 344227.5
Participants: 3
Project status: CLOSED

A faced challenge for the CROR concept is to maintain the current level of safety mandated by aviation and certification regulations and to provide blade impact mitigation at the airframe level without resulting in a large weight penalty. This leads to a demanding impact analysis and design problem of two complex composite structures, the fuselage structure (target) and the CROR blade or fragment structure (impactor). The main aim of the proposed research is to develop a robust, computationally efficient, multi-scale numerical simulation model, based on ABAQUS Explicit FE solver, for the virtual-testing of partial or full-scale CROR blade impacts. Following common practice, a building block approach is employed to validate the predictive FEA capabilities. Specific objectives of the project are: (1) Design of Representative Blade Specimens; (2) Development of multi-scale explicit impact Finite Element Models; (3) Manufacturing of Representative Specimens. The project will primarily focus on the development and validation of robust and mature ABAQUS Explicit FEA models coupled with GENOA multi-scale composite mechanics and progressive damage analysis software, for the numerical simulation of impact of CROR blades. Virtual testing will be supported by a physical testing building block plan. A series of representative coupons and physical bade specimens will be manufactured using the RTM method. Low level tests entailing material characterization and representative impacts of composite plates will be conducted to provide all necessary material properties and the verification of the constitutive material models starting from micromechanics scale. The fabrication of all blade specimens will enable the comprehensive validation and improvement of numerical FEA models to ensure realistic predictive capabilities with respect to impact behavior of the blade impactor structure.

Keywords: cror bladeout genoa abaqus rtm pfa fem multiscale implicit explicit composite micromechanic
Ecological Migration During High Imperialism. German Qingdao As Meeting Point of International Species, 1898-1914. (ECOMIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

ECOMIG aims to uncover the environmental history of the German colony of Qingdao located at China's Yellow Sea (1898-1914). Adopting a multi-species ethnography, I will research the production of a colonial "other" by foreign forces. So called "Western" countries intended to open a market that had won the reputation of a capitalist/traders' Eldorado. Themselves being perceived as invaders by the locals, they introduced a variety of international animals and plants. Some of these were adopted by the Chinese as well, others became "invasive species" in the modern word sense. While the military and socio-economic aspects of this brief Imperialist take over have already been explored, its ecological impact remains unknown. German economic ambitions in China included an army of plants intended to redesign the local environment that needed aesthetic improvement and should become a source of renewable resources. The effects of this economically motivated forced migration allow insights on historical narratives at the conjunction of environmental, colonial and economic history, emphasizing the intimate connection between human and environmental questions. ECOMIG addresses these questions exploring the semantic relationship between "eco-nomy" (household management) and "eco-logy" (household systematics) that signify an important crossroad for the realms of the infamous nature and culture divide.

Keywords: environment and society,environmental humanities,language use,cultural narratives
BIMcert – 1. Construction skills, 2. Energy efficiency, 3. Regulating supply chains, 4. Tackling climate change (BIMcert)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Ireland,North Macedonia,Croatia,Portugal,United Kingdom,United Kingdom
Call: Construction skills (H2020-EE-2017-CSA-PPI, 2017)
Start date: 2018-03-01
End date: 2020-01-31
Duration (months): 23.0
Total project cost (EUR): 1242137.75
EU funding (EUR): 1242137.75
Participants: 8
Project status: CLOSED

A Transparent Training Model and toolkit enabling and empowering industry to achieve a greener built environment. To develop a more efficient and relevant training programme materials to integrate concepts of sustainability and renewables together it practical application and integration with technology ( BIM) based on real life industry needs and limitations.

Keywords: efficient near zero carbon buildings,delivering jobs and sustainable growth through efficient construction
Social-ECological Interdependencies in TransboundarY water resources systems (SECurITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

More than 286 internationally shared river basins supply 60% of global freshwater. The United Nations and the Council of European Union has highlighted the potential of transboundary water diplomacy. The complex interdependencies between humans and water in these transboundary basins remain poorly understood in the newly proposed discipline of socio-hydrology. Therefore, an assessment of social-ecological interdependencies in transboundary water resources systems is now urgently required for implementing target 6.5 of SDGs and for fulfilling the EU’s commitment on international peace and security. The overall objective of the envisaged research is to develop new understandings of complex human-water systems in large transboundary river basins with an aim to contribute scientific advancement of socio-hydrology and to enhance transboundary cooperation for international peace and security. The proposed research will be hosted in two highly qualified laboratories (during outgoing phase at MIT, with Prof. Susskind and during return phase at UNIVE with Prof. Giupponi). Going beyond the state-of-the-art, the proposed project will develop for the first time: an analytical framework of complex tranboundary water system; comparative network analysis for social ecological systems in two river basins; consideration of negotiation theory and role-play game in developing transboundary cooperation strategies. The proposed project is fundamentally interdisciplinary in characters. The scientifically innovative and socially relevant (for EU and the Globe) proposed project will help me achieve higher levels of professional maturity through innovative research, advanced training, the transferrable skills and interdisciplinary experiences in two highly qualified institutions both at MIT and at UNIVE. These unique experiences will support to achieve my short-(e.g., human-water interactions), medium- (e.g., young investigator) and long-term (permanent position in academia) career goals.

Keywords: human water interaction,transboundary water system,network analysis,negotiation theory,socio hydrology,stakeholder engagement
VERtical Innovation in the Domain of Robotics Enabled by Artificial intelligence Methods (VeriDream)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,France,France,Czechia
Call: EIC Transition to Innovation Activities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 1988670.0
EU funding (EUR): 1988670.0
Participants: 7
Project status: SIGNED

Advances in artificial intelligence (AI) are changing the business models of many companies, and creating entirely new ones. But whereas the general public associates AI predominantly with autonomous and humanoid robots, the economic impact of AI on robotics has been very limited in comparison to domains which were digitised from the start, such as Internet search and social networks. This is because acting in the physical world raises many challenges related to the variability of the real world, its continuous and dynamic nature, as well as the consequences of suboptimal or erroneous behaviour. To address these challenges, VeriDream proposes a two-fold research and innovation strategy for AI in robotics, based on the generalisation and robustification of AI methods developed by the three research partners in two previous H2020 projects, DREAM and RobDREAM. The deep innovation strategy aims at high TRL on a set of use cases from the specific domain of warehouse logistics at the start-up Magazino. The broad innovation strategy, pursued by Synesis and GoodAI, aims at fostering a broader uptake of DREAM methods in SMEs, also beyond the project, and even beyond robotics. VeriDream thus aim at both concrete high-TRL innovation success stories, as well as providing experience and templates for innovation from which other European SMEs may profit. In both strategies, our methodology is based on "closing the innovation loop". This means that research on AI methods is driven less by performance on static benchmarks, but rather by general methodological requirements derived from the performance on multiple industrial use cases. This will require scientific advances in state representation learning, failure discovery and resolution, and continual learning. The generalisation and robustification of DREAM methods that results from this research will have a substantial impact on the innovation potential of these methods. Demonstrating this is VeriDream's mission.

Keywords: robotics,warehouse logistics,innovation for smes
Life between houses: A multiscalar interdisciplinary investigation into the creation and use of settlement open spaces by the first sedentary communities (PATIOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2025-02-28
Duration (months): 36.0
Total project cost (EUR): 241398.72
EU funding (EUR): 241398.72
Participants: 1
Project status: SIGNED

The emergence of sedentary life ca. 13,000 years ago marked the development of mudbrick architecture and the transition to new forms of human ecology based on plant and animal domestication. In this context, settlement open areas played a vital socio-economic role as the loci of discard practices, outdoor activities, and human-animal-environment interactions. However, while built environments are a recurrent research theme for this period, open spaces remain less studied. This oversight is partly due to the methodological and interpretative problems posed by open areas, often displaying complex stratigraphies consisting of superimposed microlayers and excavated in arbitrary units that do not represent units of deposition. The aim of PATIOS is to explore the constitution of open spaces to investigate how the earliest sedentarising and sustained sedentary communities operated at supra-household levels. The specific project goals are: 1) to develop a new multiscalar and interdisciplinary methodology for an improved identification of microscopic and molecular residues of organic nature in open sequences; 2) to characterise the variety of formation and taphonomic processes affecting open areas; and 3) to provide a wide diachronic and geographical understanding of the concepts and transformations of open spaces and the socio-cultural aspects related to their use. PATIOS will focus on early Holocene semi-mobile and sedentary communities in the Near East, one of the core areas of the Neolithic Transition. Through a multi-proxy methodological approach that combines spatial analyses, geoarchaeology, plant science, biochemistry and ethnoarchaeology, this project will explore the heterogeneity of the earliest settlement open areas, opening up a much-needed comparative path for the examination of local trajectories in their creation, transformation and use. Thus, PATIOS will contribute new insights into the rise and evolution of anthropogenic landscapes and ecologies.

Keywords: neolithic,near east,sedentism,open areas,geoarchaeology,bioarchaeology,ethnoarchaeology,spatial analyses,domestication,sanitation,diet,landscape,ecological strategies