Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel Semiconductor Lasers for the Industrial Quantum Leap (SEMIQLEAP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Challenge: Emerging semiconductor or quantum technology components (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 3464911.25
EU funding (EUR): 2425437.88
Participants: 1
Project status: SIGNED

Vexlum has developed a laser architecture for a high-power low-noise laser using a vertically integrated manufacturing process. The application of Vexlum’s laser to atomic-based quantum systems exploits vertical-external-cavity surface-emitting laser (VECSEL) with a quantum-well gain medium that is optically pumped and can include an intra-cavity doubling element. Historically, achieving high powers in atomic systems required amplifying and frequency-doubling external cavity diode lasers, frequency-doubled fiber lasers, or TiSaphire lasers, all of which have drawbacks. Vexlum lasers are regarded as a potentially disruptive technologies and have been validated in key quantum system experiments by early technology adopters, yet largely confined to research labs. The EIC Accelerator grant will allow us to address the industrial quantum technologies market by overcoming challenges identified by the early version products, for example related standardized volume production and operational lifetime. Our go-to-market strategy for industrial quantum systems is based on redesigning and developing the production chain from wafer level to semiconductor gain chip, and system developments with refined laser features. To this end, we focus resources on fast-tracking the development of the technology needed to reach the reliability and SWAP-C expectations of high TRL markets engaging advanced manufacturing processes based on automation routines. These capabilities would allow us to maintain our customer focus and quality while we scale-up into a business growth phase. In a broad perspective we target to secure the full scale development value chain of advanced lasers for quantum systems, capitalizing on vertical integration of semiconductor manufacturing processes from wafer design and epitaxy to system level assembly and testing.

Keywords: vecsel,laser,quantum technology,volume production,
Targeting Caspase-2 in dementia (CASPASITY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2258165.0
EU funding (EUR): 2258165.0
Participants: 1
Project status: SIGNED

IPCURE is a pioneering deep tech startup focused on developing groundbreaking drug candidates that target the underlying causes of dementias. Dementias, including Alzheimer's disease, affect over 50 million people globally, with numbers expected to triple by 2050. Current treatments are limited, only addressing symptoms with no or limited halting of disease progression. This has a devastating impact on patients, families, and healthcare systems, with an annual global cost exceeding 1 trillion dollars. IPCURE employs a robust drug discovery platform integrating peptidomimetic, chemical rational design, enzyme assays, human IPSC, and organ-on-chip technologies for drug selection, optimization, and development. The resulting compounds offer unprecedented selectivity, promising disease-modifying effects. What sets us apart is our targeting of caspase-2 with the first truly selective inhibitor compound family. This molecular target is a crucial pathogenic effector at the crossroad of Amyloid and Tau pathways, offering a unique approach to potentially halt or reverse dementia progression. Our drug candidates have been validated in cellular and animal models, internally and through international partnerships. With the support of the EIC Accelerator, we aim to accelerate the development of our drug candidate, moving toward clinical trials. EIC funding will enable us to complete preclinical regulatory studies of our Caspase-2 inhibitor, expand intellectual property, produce GMP batches, secure EMA agreements. We will concomitantly raise additional funds to conduct clinical phase 1 trials Our vision is to bring to market the first truly effective treatment for dementias, transforming lives and reducing the global burden of these diseases.

Keywords: alzheimer s disease,frontotemporal dementia,selective inhibitors,preclinical,drug development
Volatile evolution on terrestrial planets (Kryptonis)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2382203.0
EU funding (EUR): 2382203.0
Participants: 1
Project status: SIGNED

Volatile elements, such as water, carbon and nitrogen, with low condensation temperatures, are needed to achieve and sustain habitable conditions. They also regulate planets geodynamics and climate evolution. However, how these volatiles were delivered to terrestrial planets and how they subsequently evolved is actively debated. Due to their inertness and high volatility, the noble gases krypton and xenon are unique geochemical tracers of volatiles. Their non-radiogenic isotopes have kept the signatures of the sources that delivered volatiles to planets and of the evolutionary processes subsequent to accretion, like recycling via subduction. Yet the non-radiogenic krypton and xenon isotopes have barely been used, in particular for krypton, due to major analytical challenges. Here, I propose to develop an original geochemical tool, the non-radiogenic krypton and xenon isotopes. I will develop innovative analytical protocols to allow high precision measurements of these isotopes. The objectives are to determine the source(s) of volatiles for terrestrial planets and to assess when volatiles started being recycled into the Earth’s mantle via subduction. To achieve these goals, I will (i) determine the precise krypton and xenon compositions of different types of meteorites to evaluate whether one meteorite type can explain the signature of the Earth’s and Mars’ mantles, (ii) assess the volatile source(s) of the Martian mantle by studying the krypton and xenon compositions of the Martian meteorites shergottites and nakhlites, (iii) determine the krypton and xenon compositions of different Earth’s mantle sources, from the present-day to the Archean, by analyzing mid-ocean ridge basalts and granitoids. The analyses on granitoids will be combined with high-pressure high-temperature experiments to study the krypton and xenon elemental fractionation processes, which will be key to providing a global understanding of the measured fluid compositions in granitoids.

Keywords: volatile origin,volatile evolution,meteorites,earth s mantle,mars,noble gases,krypton,xenon,experimental petrology,isotopic analyses
Legacies of Race and Slavery in Turkey (LERSiT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Throughout the nineteenth century, slavery in the Ottoman Empire relied heavily on Black female domestic labor. After the dissolution of the Empire (1922), the descendants of these enslaved Africans remained in the region and eventually became citizens of the Turkish Republic, identifying as Afro-Turks. Despite the significant historical presence, Ottoman slavery is often overlooked in global slavery studies and mainstream Turkish historiography, and today, the Afro-Turk community faces various forms of microaggressions on a daily basis. However, the exclusion of the Ottoman Empire and the Middle East and North Africa (MENA) from studies on the legacies of slavery is not just a matter of geography, nor is the neglect of the history of slavery in Turkey and other countries in the region accidental. Instead, it reflects a larger global trend: the long-standing systemic marginalization of gendered domestic work from analyses of the development of capitalism and labor studies. Accordingly, this research has three main objectives: (1) to investigate the erasure of domestic slavery in Ottoman history and its impact on Turkish identity and Afro-Turks’ experiences; (2) to expand the sociological analysis through late Ottoman archival materials, tracing racial ideologies from the Ottoman Empire to the Turkish Republic; and (3) to disseminate this scholarship through a complementary visual digital project investigating the urban and rural sites that bear the mark of this history in the region. By examining the history of Ottoman slavery and its effects on contemporary Turkey, this project aims to create a framework that highlights how global patterns of gender oppression and racialized enslavement are interconnected. In doing so, LERSiT will highlight historical contexts often overlooked in studies of colonialism and slavery, thus broadening our understanding of historical and racial formation theories.

Keywords: racialization,racial formation,slavery,domestic labor,ottoman empire,turkey,middle east
Creating a Gold Standard for AI Algorithms in Healthcare (Medana AI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Medāna AI, a dynamic startup based in Ireland, is developing an innovative platform designed to validate AI health algorithms, aiming to revolutionize decision-making in healthcare. Our vision is to enable the effective use of medical AI algorithms in healthcare by offering a global platform that will enable the automated validation and seamless implementation of medical AI algorithms. Medāna AI bridges the gap between the promise of AI driven personalised medicine and its lack of actual on-the-ground implementation and is led by renowned global experts in the fields of Health, Technology, Algorithms and Medical Data. Medāna AI will enable healthcare providers, HMOs, and health insurers to quickly and securely incorporate AI solutions, setting a new standard for deep clinical validation and personalized implementation of AI algorithms in medicine. Our goal is to enhance the global deployment of health AI algorithms by ensuring compatibility and correlation with diverse populations, societies, and healthcare settings worldwide. This initiative aims to establish new benchmarks in diagnosis, treatment, and prevention in medical practice, delivering equitable solutions. Ultimately, our platform will address significant healthcare challenges and facilitate equitable access to high-quality care while managing escalating costs. Medāna AI’s overarching goal is to enable the effective use of medical AI algorithms in healthcare, thereby establishing a Gold Standard for AI algorithms in medicine and promoting their safe and seamless integration into healthcare delivery across Europe and globally. As the volume of health algorithms, AI models, and Large Language Models (LLMs) dramatically increases, there is an urgent need for regulation and standardization in the AI and healthcare sectors. By 2030, Medāna AI aims to enable hundreds of healthcare organizations worldwide to safely implement and manage comprehensive AI strategies.

Keywords: patient care,algorithm validation,artificial intelligence transparency,diagnostic tools,clinical medicine,ehealth,economics of healthcare,equitable access to healthcare
Fighting Addictions, improving Lives: COmprehensive drug rehabilitation with music (FALCO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Israel,Italy,Poland,Spain,Switzerland,Austria
Call: Comparative effectiveness research for healthcare interventions in areas of high public health need (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 8995781.0
EU funding (EUR): 8995781.0
Participants: 19
Project status: SIGNED

Objectives and ambition: Substance use disorder (SUD) is associated with a high global burden of disease, with 5.4% of all disability-adjusted life years lost due to alcohol and illicit drugs. Highly prevalent multimorbidity includes polysubstance use, mental health conditions, and other non-communicable and infectious diseases. Where traditional treatments are insufficient alone, music therapy (MT) is highly engaging and improves motivation and craving, but its long-term effects are unknown. Methodology: In a diverse group of people with SUD across a wide range of age, gender, socioeconomic, and cultural background, a parallel 3-arm assessor-blinded pragmatic multinational randomised clinical trial with embedded exploratory trials and mechanistic studies will determine long-term effects of active music groups (AMG) and music listening groups (MLG) versus treatment as usual (TAU) on addiction severity (primary: 1 year), recovery, and other health and socioeconomic outcomes. Embedded trials will examine short-term effects of individual components of TAU combined with AMG or MLG to determine the best combinations of interventions. Experimental studies will examine mechanisms using neuropsychological tests and brain imaging. With 600 participants in 7 countries randomised, the trial has 80% power on the primary outcome. Patient representatives, HTA bodies, and interventionists have been involved from conception and will ensure feasibility and applicability across Europe. Impact: FALCO will reduce disease burden through innovative, effective, and affordable treatment and will strengthen research and innovation expertise. Recommendations from FALCO will inform intervention delivery across Europe and beyond, leading to increased safety, effectiveness and cost-effectiveness, and improved quality of life for people with SUD. Stakeholders will be involved in communicating findings in all European countries and regions and ensuring that findings are effectively implemented.

Keywords: substance use disorder,addiction,recovery,music therapy,mental health,brain health
A small window to the future of our oceans: genomic divergence, plasticity and microbiome shifts in marine invertebrates along natural pH gradients (DIVERGEN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-12-31
Duration (months): 28.0
Total project cost (EUR): 190453.52
EU funding (EUR): 190453.52
Participants: 2
Project status: SIGNED

Ocean acidification (OA) is a global problem caused by the rapidly increased CO2 emissions to the atmosphere since the Industrial revolution. Ocean acidity is predicted to increase from 100% to 150% by 2100, which will affect half of the marine biodiversity. The resilience, adaptive and survival potential of marine organisms to OA can highly vary among species, and the broader implications for ocean ecosystems are far from known. In this sense, marine CO2 vents, which generate pH gradients over short geographical distances, provide a perfectly designed natural laboratory to study the long-term effects of OA and to look into the future of our oceans. The project aims to understand the biological strategies of calcifying marine species to overcome the effects of OA, using a keystone echinoderm widely distributed across a current natural gradient of pH. We will use an innovative and multidisciplinary approach combining transcriptomics and metagenomics together with physiological and ecological data to provide a deeper understanding of the adaptation and plasticity of echinoderms. This proposal will focus on different biological characteristics that determine the potential of the species to survive and adapt to changing environments and generate important knowledge about 1) intra- and inter-specific processes to cope with rapid environmental change, 2) adaptative evolution versus phenotypic plasticity in the biological responses of organisms, 3) larval microbiome to modulate responses to environmental stresses and 4) the vulnerability of the different life phases of organisms to climate change. This information will allow us to understand the buffering systems and adaptation strategies used by the species, predict the resilience of organisms to OA and finally, fill a relevant knowledge gap in ecological genomics.

Keywords: ocean acidification,climate change,next generation sequencing,metabolism,metagenomics,microbiome,marine invertebrates,larvae,symbionts,adaptation,phenotypic plasticity
Integrated Assessment Models with Circular Economy and Material Balance (IAM-Circ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

For most of history, economic growth has gone hand in hand with increased material use. For a sustainable future we need to break this relationship. We can reduce the material impact of the economy through less intensive use of materials, longer use of materials over time and develop a circular economy where material loops to reduce losses. The circular economy implements a more sustainable economic paradigm, as opposed to the current linear economic model, which is based on the "extract/consume/discard" tryptic. The European Union (EU) and member states also promote the circular economy as a political and economic target. To inform policy makers on how to address sustainability issues, researchers develop models, such as integrated assessment models, considering long-term growth and linking economic variables to biophysical features such as climate change. However, these models rarely include full material consistency and thus have limited say for circular economy innovations. The objective of this project is to bridge the existing scientific gap between economic modelling and material flows. To this end, IAM-Circ will develop an integrated assessment model that combines macroeconomic characteristics with growth and circular economy features through material use constraints. Building economic theory and running calibrated scenarios with the model will allow to contribute to scientific research on circular economy and identify policy measures that combine socio-economic objectives, circularity, and environmental strategies, to be implemented at national and EU levels.

Keywords: integrated assessment models policy material flow analysis recycling
Theoretical analysis of fluid-structure interaction problems and applications (THANAFSI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Italy,Belgium,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: SIGNED

The THANAFSI project aims to contribute to the Sustainable Development Goals of the UN Agenda 2030 by improving the understanding of the behavior of infrastructures of current worldwide social interest through the analysis of suitable mathematical models. The project will tackle two main fluid-structure interaction (FSI) problems arising, respectively, in civil and coastal engineering: (1) the stability of suspension bridges under the action of the wind, (2) the impact of ocean waves on oscillating water columns (OWCs). Three research lines will be developed: (a) study the global existence and uniqueness of the solution to a 2D wind-bridge model in non-symmetric configurations for arbitrarily-shaped structures and focus on the asymptotic stability of the equilibrium state, (b) study the existence and uniqueness of the solution to a 3D wind-bridge model, both in symmetric and non-symmetric configurations, (c) study the local well-posedness of 1D Boussinesq-Abbott system in presence of an OWC and estimate the order of the existence time. The achievement of these challenging goals will move the boundaries of the mathematical comprehension of FSI problems. Nonlinear effects will be taken into account in (a)-(b) improving the comprehension of wind-bridges interaction in order to prevent catastrophes and design reliable suspension bridges. Both nonlinear and dispersive effects will be considered in (c), advancing the mathematical knowledge of wave energy converters, crucial to increase their energy efficiency. The THANAFSI project will be carried out by the Researcher, who worked during his PhD on the mathematical analysis of floating structures in shallow water waves, and then as a postdoc moved on to thin film approximations for fluids in porous media. The Researcher will interact with the Supervisor, a prominent expert in mathematical models of suspension bridges and in analysis of FSI problems, with whom he is currently collaborating.

Keywords: fluid structure interaction,elasticity pdes of suspension bridges,navier stokes equations,water waves equations and structures,boussinesq abbott system,qualitative properties of solutions of pdes