Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Neuron Type Atlas of the Annelid Brain: Development and Evolution of Chemosensory-Motor Circuits (BRAINEVODEVO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 2489048.0
EU funding (EUR): 2489048.0
Participants: 1
Project status: CLOSED

Neural circuits, composed of interconnected neurons, represent the basic unit of the nervous system. One way to understand the highly complex arrangement of cross-talking, serial and parallel circuits is to resolve its developmental and evolutionary emergence. The rationale of the research proposal presented here is to elucidate the complex circuitry of the vertebrate and insect forebrain by comparison to the much simpler and evolutionary ancient “connectome” of the marine annelid Platynereis dumerilii. We will build a unique resource, the Platynereis Neuron Type Atlas, combining, for the first time, neuronal morphologies, axonal projections, cellular expression profiling and developmental lineage for an entire bilaterian brain. We will focus on five days old larvae when most adult neuron types are already present in small number and large part of the axonal scaffold in place. Building on the Neuron Type Atlas, the second part of the proposal envisages the functional dissection of the Platynereis chemosensory-motor forebrain circuits. A newly developed microfluidics behavioural assay system, together with a cell-based GPCR screening will identify partaking neurons. Zinc finger nuclease-mediated knockout of circuit-specific transcription factors as identified from the Atlas will reveal circuit-specific gene regulatory networks, downstream effector genes and functional characteristics. Laser ablation of GFP-labeled single neurons and axonal connections will yield further insight into the function of circuit components and subcircuits. Given the ancient nature of the Platynereis brain, this research is expected to reveal a simple, developmental and evolutionary “blueprint” for the olfactory circuits in mice and flies and to shed new light on the evolution of information processing in glomeruli and higher-level integration in sensory-associative brain centres.

Keywords: development and evolution,platynereis dumerilii,single cell transcriptomics,light sheet microscopy,neuron type atlas,profiling by image registration,connectome
Synthetic Biology Approach to Adhesion-Mediated Environmental Sensing (SYNAD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Germany,Israel
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-05-01
End date: 2018-04-30
Duration (months): 72.0
Total project cost (EUR): 3499799.0
EU funding (EUR): 3499799.0
Participants: 2
Project status: CLOSED

The primary aims of this work are tightly connected: (i) development of a bio-inspired “synthetic cell” capable of self-assembling, self-propelling and environmental sensing prepared with reduced molecular complexity compared to living cells (ii) quantitative assessment of the bio-activity of specific cellular components within these “synthetic cells”, leading to better fundamental understanding of their function in living cells (iii) use of these findings for reverse engineering of living cells with tailored adhesive and sensory properties. Integrin based adhesion has been shown to participate in numerous processes in living cells, which sense, via their adhesions, multiple environmental cues, integrate them, and develop a complex, multi-parametric response. However, due to their intrinsic molecular complexity the specific functional roles of different components of the adhesion site are still poorly understood. To address this issue, we will utilize current knowledge of the modular nature of focal adhesions and related integrin-mediated extracellular matrix contacts to develop “synthetic cell” models, consisting of large lipid vesicles, functionalized by transmembrane integrins, various integrin-binding proteins and specific sets of scaffolding and signaling proteins of the adhesion sites. The one-by-one loading of these vesicles by micro-injection with these proteins will allow tight control of the system composition and complexity, and testing of the effect of compositional and environmental variations on the adhesion and signaling features. The “synthetic cells” will be plated on adhesive matrices displaying specific spatial, chemical and mechanical features for testing their chemical and mechanical sensing capabilities. The datasets produced in these experiments will provide a solid basis for reverse engineering perturbations of living cells, in which specific functional pathways will be targeted and/or modified to modulate living cells' functionality.

Keywords: cell adhesion,molecular cell biology,biomimetic,materials science biofunctionalisation,nanopattern,integrin,actin,lipid vesicles,phosphorylation,adhesome,signaling
Development of Electrochemical Peptide Nanosensors for protein and antibody detection (PEPTIDE NANOSENSORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,Spain,United Kingdom
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-05-01
End date: 2015-04-30
Duration (months): 36.0
Total project cost (EUR): 218700.0
EU funding (EUR): 191400.0
Participants: 3
Project status: CLOSED

The overriding goal of the proposed research program is the development of novel reagentless, electrochemical peptide based sensors for the detection of multiple diagnostic proteins. The approach, which will utilize electrochemistry to monitor the binding-induced folding of peptide/polypeptide used as recognition elements, will be rapid, specific, convenient, and critically, selective enough to be employed directly in blood serum and –we propose- whole blood. This goal will be achieved bringing together an international and interdisciplinary group of research teams and building a collaborative environment for research, innovation and technology transfer in the field of electrochemical nanosensors. This program will allow the exchange of knowledge and expertises through training visiting periods of early stage and experienced researchers. The training will involve each single aspect of sensor development. For this reason, the research teams selected encompass all of the requisite expertises and each of them has a particular focus on a single step of sensor production and testing. The outcome of the fellowship will be crucial for the early stage researchers involved. This in fact will strengthen their scientific knowledge through a focused training at the host institutions and will facilitate the acquisition of experience in new, interdisciplinary fields at the interface of analytical chemistry, electrochemistry, molecular biology and clinical chemistry. The program will also allow the exchange of experienced researchers. This will give the possibility to build a strong net of collaboration, which will be very important for future careers of the involved scientists. The laboratories involved have similar objectives but with completely different scientific approaches and expertise, this program will help the integration and collaboration among the research teams and the establishment of a long-term collaboration between Europe and key Third Countries.

Keywords: clinical chemistry,electrochemistry,surface chemistry
EU Cooperation Capacity Building of Center for Ecological-Noosphere Studies of National Academy of Sciences of Armenia: Towards Armenia’s integration into the ERA (ECOARM2ERA)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Armenia,Ireland,Switzerland,Germany
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-12-01
End date: 2014-11-30
Duration (months): 36.0
Total project cost (EUR): 560700.0
EU funding (EUR): 499957.0
Participants: 4
Project status: CLOSED

The central goal of EcoArm2ERA is to reinforce the international research cooperation between Armenian leading institute in environmental and ecological studies CENS and ERA in the critically important areas, specifically FP7 Themes as Environment, KBBE and Space (e.g. GIS technologies for environment)). This goal will be attained through pursuit of the following specific objectives: • Objective1: To define and promote a sustainable development strategy for the Armenian CENS focusing on the overall improvement of the institution’s capacities, visibility, and competitiveness. • Objective 2: To develop a strategic partnership between CENS and (i) the School of Geography, Planning and Environmental Policy, Earth Sciences Institute, University College Dublin (NUID UCD), and (ii) the Institute of Environmental Sciences, University of Geneva (UNIGE). To build a CENS’ capacity to acquire and carry out international collaborative research partnerships. • Objective 3: To build the competencies needed by Armenian researchers and staff members in order to participate in the FP7/FP8 programme. EcoArm2ERA brings together top-level partners from both ERA and Armenia: CENS created with the mission to integrate the Armenian research capabilities in the field of environment and sustainable development. CENS will be main beneficiary of the project. CENS will be directly supported through its European twinning partners: NUID UCD – Earth Sciences Institute of the University College Dublin and Institute of Environmental Sciences, University of Geneva, who will provide and open up their scientific and networking capabilities and serve as strategic link to the European RTD community. Last but not least, the consortium is accomplished by GIRAF (a specialist training provider and project management expert with expertise in institutional development and organisation).

Keywords: environment,gis technologies,rtd cooperation capacity building,training,strategy development
Reinforcing Capacity Building for Defending Biodiversity in the Palestinian Territories (DEBPAL2)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Palestine, State of,Italy,Belgium
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 558920.0
EU funding (EUR): 499237.0
Participants: 4
Project status: CLOSED

The objective of DEBPAL is to reinforce the cooperation capacities of Al-Quds University, to improve its researches activities in defence and recovery of Biodiversity (including Agro-Biodiversity), in the interlinked fields of conservation and restoration as requested by the international Convention on Biological Diversity, a major commitment in the European Union main politics. The Palestinian Territories are an emblematic case of massive Biodiversity loss, determining a series of severe consequences on the nature’s state and on human life and economy. From this point of view it is important to remember that the Convention on Biological Diversity considerate the Agro-Biodiversity an essential part of the Biodiversity inextricable whole, to protected by the States Parties. Therefore, the competences, techniques and technologies that will be developed in AQU are focused at integrating Biodiversity, cultural and social perspectives into a coherent sustainable landscape management. This approach is strategic for the Palestinian Territories but also, in a larger dimension, for the whole of the Mediterranean Region, where the erosion of Biodiversity is a worsening and expanding problem due to the human impact on the environment and the absence of consistent global politics to combat and control it. The Capacity building of AL-Quds University in this strategic field will be increased by : Networking and joint research activities in Biodiversity conservation and restoration and related socio-economic aspects, with a well experienced Italian University. Training in nursery activities with a Italian SME already involved in several EU research project in this field. Training in EU projects approach, selection, preparation and submission, with a Belgian not for profit research association. Development of an Al Quds University’s research/policy strategy, able to support the Government in its related planning activities, according to the EU Policy and objectives.

Keywords: biodiversity,international cooperation,networking training,new business model
Sustainable Water ActioN: building research links between EU and US (SWAN)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Strengthening European research facilities in third countries: INCO-LAB activity
Action type: Coordination and support actions
Countries involved: France,United States,United Kingdom,Spain,Bulgaria,France
Call:  (FP7-INCO-2011-7, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 2356551.0
EU funding (EUR): 1999202.0
Participants: 6
Project status: CLOSED

The project promises to strengthen European research capacity in the USA, promote competitiveness of European research and industry while informing and involving policy-makers and the general public. Opening the UMI to European partners responds to the need for 21st Century interdisciplinary and multiregional collaboration regarding water sustainability. We have exhausted the 20th century paradigm of technocratic or institutional solutions and are compelled to apply multi-faceted approaches that combine physical, natural, and social sciences, along with governance perspectives. This extension of the UMI broadens its current activities from a bi-national focus to one that incorporates ideas, disciplines and methods from Europe. By connecting the UMI with Europe, scientific cooperation will enhance ongoing activities, bring new projects, establish a foundation for future collaboration in the framwork of a EU/USA Sustainable Water Centre (SWC). A Feasibility Study will fully explore how the UMI will achieve this major institutional step. To optimise the cooperation among partners, three major transverse themes will structure the work plan: Climate change and uncertainty, Risks and vulnerabilities and Participation. Work Packages are: 1)Water resources sustainability, 2) EU/USA issues in water governance, 3) Water demand and sustainability, 4) Urban water: EU/USA common models 5) Feasibility Study, 6) Management Strategy; 7) Dissemination/communication.

Keywords: sustainability,water resources and supply,wastewater,urban water,environment,climate change,urban regions,cities,integrated approach,modelling,participation,education,stakeholders
Computable Analysis (COMPUTAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,United Kingdom,Germany,Slovenia,Germany,United Kingdom,Germany
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 400600.0
EU funding (EUR): 350200.0
Participants: 7
Project status: CLOSED

The proposed programme focusses on logical and algorithmic aspects of processing infinite data. Through a network of institutes from three European and three Third countries, all of them among the leading groups in the relevant research, we aim at facilitating the interplay between the underlying branches of computable mathematics, i.e. computable analysis and topology, as well as exact real number computation.

Keywords: algorithms,mathematical logic,computable analysis,exact real number computation,domain theory,topology,infinite computations,hybrid systems,degrees of discontinuity,hierarchies
Promoting and Improving Azerbaijan Research Collaboration with European Research Area (PRIMA-ERA)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: France,Türkiye,Azerbaijan
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 567488.0
EU funding (EUR): 498621.0
Participants: 3
Project status: CLOSED

The PRIMA-ERA project is designed to reinforce research collaboration between the Institute of Physics, Azerbaijan National Academy of Sciences (IPA) and research centres in the European Research Area. The IPA is a leading organization on scientific research, knowledge transfer and graduate education in physics in Azerbaijan. PRIMA-ERA will facilitate the collaboration of the IPA with research centres in EU member and associate countries and reinforce its engagement in the FP7 projects in research topics covered by such thematic priorities as energy and nanotechnologies. The primary objectives of the project are: - to increase IPA capacities and preparedness for collaboration in the FP7 through twinning and networking, development of joint research plans and training modules and trainings; - to increase visibility of IPA for international scientific community and other stakeholders through dissemination of scientific information and promotional activities; - to ensure the compliance of the IPA’s research activities with socio-economic needs of the country and regionally and provide better career opportunities for young scientists through encouragement innovative approaches and development of research strategy. The project consortium between the IPA, CNRS Institut de Recherche et Development sur l’Energie Photovoltaique, CNRS-IRDEP (France) and TUBITAK – Marmara Research Centre, TUBITAK - MAM (Turkey), has been established to effectively fulfill the project’s objectives. The PRIMA-ERA will comply with the EU strategies for an “open ERA” as mentioned in the EC Communication for International S&T Cooperation by providing mobility and access to research facilities between the centres with similar research interests. The project actions will be in coherence with the concept of the “mutual interests of the EC and the ENP partner countries” as stated in the mentioned Communication.

Keywords: rtd capacity building,twinning,exchange of knowledge,fp7 trainings,opportunities for young researchers,networking,information dissemination
Transition States for Multielectron Ionization Phenomena (TRANS-MI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,United Kingdom,Spain
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-05-01
End date: 2016-04-30
Duration (months): 48.0
Total project cost (EUR): 119700.0
EU funding (EUR): 81900.0
Participants: 3
Project status: CLOSED

Probing atomic or molecular systems with ultrashort and near-optical lasers remains a tremendous challenge while their understanding exerts a significant impact on science and industry by enabling a series of cutting-edge techniques: the production of lasers with ever shorter wavelengths by high harmonic generation, analysis by laser induced electron diffraction, and orbital tomography, to quote just a few applications. This new field of physics and engineering, "attosecond science", investigates the motion of the electrons on their own time the time scale of motion. These laser-driven systems are perfect for the investigation of both quantum and classical approaches. The results obtained using both frameworks can be compared with actual up-to-date experimental results which are currently pursued world-wide. The project we are proposing concerns the classical mechanical treatment, which has been recognized as surprisingly accurate since the early 90’s because of the dominant role of electron correlation. The main advantage of the classical mechanical approximation is the power-law scaling of its representation with system size, compared with the exponential increase of complexity of quantum mechanics. Our objective is to apply tools from chemical physics describing chemical reactions using transition state theory (a key element of chemical reaction theory) to sub-atomic processes involving a strong electron-electron correlation as encountered in attosecond science. The project aims at linking mathematicians, physicists and chemists to build a unified theoretical framework to tackle the complex dynamics in laser-matter interactions. The proposed collaborative project will be coordinated by the Center for Theoretical Physics (CNRS) in Marseille (France) and will involve the School of Mathematics of the Loughborough University (UK), as well as the School of Physics and the School of Chemistry at the Georgia Institute of Technology (USA).

Keywords: atomic physics,reaction mechanisms ands dynamics,chaos theory