Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unfolding the dynamic interplay of mechanical and molecular processes in brain folding (UNFOLD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Germany,Belgium,France
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-04-01
End date: 2030-03-31
Duration (months): 72.0
Total project cost (EUR): 10770990.0
EU funding (EUR): 10770990.0
Participants: 4
Project status: SIGNED

Mammals with large brains and higher cognitive functions have a richly folded cerebral cortex. Folding abnormalities are linked to various cognitive disabilities. Despite its relevance in clinical diagnostics, the causes and consequences of cortex folding remain poorly understood. While cortex folding was long assumed to result from a limited skull volume, it is a developmental process intrinsic to the cortex. We hypothesize that cortex folding emerges from a dynamic interplay between mechanical and molecular processes, and that far from being an epiphenomenon, it has major consequences for brain architecture and function. UNFOLD will test this hypothesis by integrating genomics, cell biology, mechanics of brain development and computational modeling. Our interdisciplinary team will apply in vitro, in vivo and in silico approaches to brain tissue of strategically selected animal models. First, we will map molecular, cellular, and mechanical events accompanying cortex folding. Next, we will investigate the effects of genetic perturbations of cell biological processes on tissue mechanics, and vice versa, to identify key mechanisms leading to cortex folding and elucidate their dynamic interactions. Then, we will test the universality of these mechanisms by inducing folds in species with a smooth brain. Finally, we will decipher the consequences of cortex folding on neural circuit function and animal behavior. Our project integrates current, opposing concepts of cortex folding by adopting an interdisciplinary and multiscale perspective. Unraveling the dynamic interactions between molecular, cellular, and mechanical events during development will provide unprecedented insights into the determinants of cortical anatomy and brain organization. Our work, bridging physical and life sciences, will lead to new insights into normal and pathological brain development, paving the way to a new research area of integrated neurobiology with potential applications in modern medicine.

Keywords: cerebral cortex folding ferret mouse neurogenesis neuron migration viscoelasticity radial glia cell xenopus development mechanics afm tissue mechanics
Regions for climate change resilience through Innovation, Science and Technology (RESIST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Norway,Portugal,France,Germany,Belgium,Austria,Spain,Finland,Greece,Denmark,Sweden,Latvia,Italy,Ukraine
Call: Large scale demonstrators of climate resilience creating cross-border value (HORIZON-MISS-2021-CLIMA-02, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 26682827.75
EU funding (EUR): 24949990.25
Participants: 62
Project status: SIGNED

RESIST will strengthen the resilience and accelerate the transformation and increase adaptive capacity of 12 climate-vulnerable EU regions, implementing 4 large-scale demonstrators of resilient innovations for Climate Change Adaptation (CCA) with quintuple-helix partnerships (including 1 in a less developed region) and promote transfer of know-how and innovative solutions to 8 twin regions (of which 4 less developed regions) through both physical mutual-learning activities and innovative immersive digital twins. The consortium will engage EU associations, CCA research groups, scientific experts, social engagement and communication institutions, innovation agencies and 1 Venture Capital Fund to co-create and validate innovative solutions, raise awareness, leverage citizens participation and promote sustainable exploitation of results towards the markets. RESIST will contribute to the EU agenda on CCA, through intervention in 3 main areas: Promote and demonstrate an innovative, more participative approach to resilience and CC adaptation in 4 demonstrator and 8 twinning regions (including 5 less developed regions in total) demonstrating >12 new solution lines, accelerating regional resilience and helping reach the adaptation-mission objectives of ‘building resilience and upscaling solutions through 100 demonstrators and accelerating the transition in 200 pilot regions and communities by 2030’ reaching already 4% and 6% of these aims by 2027, with 4 demonstrators and involvement of 12 regions Co-design and contribute to the development of new regional measures, policy instruments and social and technological solutions in 12 regions involving 22m citizens, increasing awareness/resilience by 10% and levels of green investments by 20%, reducing economic losses due to natural hazards such as floods by 14% and climate protection gap by 50%; Reduce time-to-market/risk for >100 new CCA Solutions from providers across Europe, offering them scale-up for their products.

Keywords: innovation,climate resilience,large scale demonstrators,scalability,regional funding
DoctorAte in Sport Ethics and Integrity (DAiSI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Switzerland,Monaco,Austria,United Kingdom,Germany,Norway,Italy
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2985883.2
EU funding (EUR): 2985883.2
Participants: 14
Project status: SIGNED

The DoctorAl Training Network in Sport Ethics and Integrity (DAiSI) is an interdisciplinary network comprised of 5 prestigious universities (KU Leuven (Belgium, lead), Johannes Gutenberg University Mainz (Germany, beneficiary), Norwegian School of Sport Sciences (Norway, beneficiary), Swansea University (Wales, beneficiary), and University of Lausanne (Switzerland, associated partner)) and 8 leading international sport federations, sport organisations and non-governmental organisations: International Olympic Committee (IOC), International Federation of Football Associations (FIFA), Union of European Football Associations (UEFA), United Nations Office on Drugs and Crime (UNODC), World Anti Doping Agency (WADA), International Biathlon Union (IBU), and Athletics Inegrity Unit (AIU). Our research domains include cheating, doping, match-fixing, data protection, sexual harassment and abuse, credibility, reputation and damage-limitation. We examine the problems, identify published and novel solutions, deliver multi-disciplinary research and work with stakeholders to improve policy and guidelines to prevent future harms to sportspersons and organisations. The network provides extensive training and interdisciplinary doctoral education to 13 selected doctoral researchers, recruited impartially from around the world. Every thesis contributes to a coherent programme of research, which takes a three-dimensional approach, at the individual, competition and organisational levels (each of which has its own ethical, legal and social challenges). Our researchers will graduate from the programme with a joint doctorate from at least two leading universities, as well as having gained real-world experience and skills that make them immensely attractive to employers.

Keywords: sport ethics and integrity,competition integrity,doping and anti doping,human rights,organised crime,personal and organisational ethics and integrity,sexual abuse in sport
Magnetoelectric 3D printing technology - the revolution of actuatable composites (EVA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Israel,Portugal,Switzerland,Greece
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2109624.25
EU funding (EUR): 2109624.0
Participants: 9
Project status: SIGNED

The EVA project puts forward a radically new 3D printing technology that will revolutionize the nature of composites, transforming them from passive elements to responsive systems that can be instructed to execute tasks – on command. A technology that can program the mechanical, magnetic and electrical anisotropy of 3D printed structures in any direction, to fabricate systems that can be wirelessly actuated to elicit variable electrical responses during operation. Such unprecedented control over the properties and active functionalities of the printed systems will offer great advantages in multiple applications such as biotechnology (e.g. scaffolds to stimulate growth and differentiation of stem cells – 1st proof-of-principle), wastewater treatment (e.g. high-efficiency catalytic membrane to free wastewaters from persistent micropollutants – 2nd proof-of-principle), next-generation robotics, security and future data-storage technologies. EVA technology will empower engineers, researchers, and industrialists wanting to develop new concepts, materials, or functional devices to fine-tune matter at will with an affordable table-top solution. A technology enabling a new generation of multifunctional actuatable composites that can be printed and leveraged to develop radically new applications impacting multiple sectors of the economy. The potential of EVA project to achieve a proof-of-principle, and validate the scientific basis of the proposed breakthrough technology through this PATHFINDER call, is shown by the immediate endorsement from respected stakeholders, e.g. multinational corporations (Siemens) and disruptive SMEs (Nanoscribe & Transpharmation), policy makers, health professionals’ organisations, patients’ associations, and end-users (healthcare and water treatment facilities). These stakeholders will play vital advisory roles on the feasibility, transferability and exploitability of the proposed technology.

Keywords: magnetic manipulation multifunctional materials 3d printing magnetoelectric composites smart materials
An AI-based Holistic Dynamic Framework for a safe Drone’s Operations in restricted and urban areas (AI4HyDrop)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Norway,Spain,France,Türkiye,Czechia,Germany
Call: ATM application-oriented Research for U-space and urban Air Mobility (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 1993112.5
EU funding (EUR): 1993112.5
Participants: 10
Project status: SIGNED

With an increasing number and diversity of potential drone operations, managing the airspace to accommodate these drones will become an increasingly sophisticated task, especially in densely populated urban areas encompassing restricted zones with dynamic environmental and operational influences. Due to the associated higher probability of conflicts, and ultimately collisions, such areas require management of dedicated structured airspace, operations, and services to help mitigate these potential hazards. Several projects are currently working on defining ConOps for U-space services. Corus and Corus-XUAM have defined a possible capabilities model, such as airspace organization and services. However, a holistic framework is necessary to create an effective and efficient flow of information between the various capabilities in order to systematically organise the airspace usage. Such an automated Air Traffic Management System will be essential for the introduction drone operations at scale. AI4HyDrop evaluates the various stakeholder needs, delivering validated concepts, defining a methodology for an airspace structure organisation and associated U-space services. The framework considers the information from other services such as meteorological and separation provision, which can then be used for flight planning approval process, prioritization. In addition, essential elements such as surveillance and contingency planning can be addressed. The framework incorporates various AI based tools and associated information flows necessary to addresses the complexity, safety and scalability required for implementing such U-space services. The proposed framework represents a digital step change in ATM, using AI as a means to overcome many critical barriers foreseen in the introduction of automated U-space services. The findings could later be expanded to support general airspace management.

Keywords: airspace structure,dynamic air segmentation,meteorological,separation provision,surveillance,artificial intelligence,urban air mobility uam,uas,u space capability model
NEW TECHNOLOGY FOR 1 MICRON RESOLUTION BIOMEDICAL IMAGING (1MICRON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Germany,Italy
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 2999999.75
EU funding (EUR): 2999999.75
Participants: 6
Project status: SIGNED

The 1MICRON project can bridge the gap in image quality between today’s digital x-ray detectors and histopathology. We will integrate CMOS electronics circuits directly into the sensor, employing an edge-on "deep silicon" geometry for monolithic sensors that ensure high efficiency. This breakthrough promises a remarkable order of magnitude improvement in spatial resolution, all the way down to 1 micron. Such a high-resolution sensor will make phase contrast imaging much more practical and efficient, and as a secondary effect this will dramatically increase the contrast in the images. Today’s pathology analysis takes weeks and when cancer cells are found at the margin or in sentinel nodes the patient is called back for corrective surgery and treatment is delayed, decreasing survival chances. The 1MICRON imaging technology can be used directly in the operating room, providing a digitized 3D volume for immediate feedback on cancer margin. The new method can save >100 000 surgical treatments per year only in Europe, saving the corresponding cost for the healthcare system. The technology could also be implemented in new markets such as developing countries, where today pathology laboratories are not accessible. A secondary objective is to provide a proof-of-principle for a new sensor for next-generation CT, coping with high x-ray flux and having low enough power consumption for a future implementation in a clinical modality. The high resolution can provide a “3D virtual biopsy” as an alternative to today’s invasive needle biopsies. Our team includes leading European experts in medical imaging, phase-contrast imaging, monolithic sensor design, pathology, radiology, surgery, and industry positions us uniquely to undertake this ambitious project. Our success can trigger a paradigm shift in both pathology and clinical x-ray imaging corresponding to the most significant advancement in decades.

Keywords: medical imaging,photon counting,monolithic sensors,cmos electronics,phase contrast imaging,spectral x ray imaging,radiology,pathology,surgery,cancer,cancer margin
Flow Controlled Prosthetic Heart Valves (StreamlineValve)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Prosthetic Heart Valves (HV), both biological (BHV) and mechanical (MHV), have improved the survival rate and the quality of life of valvular heart-disease patients over the last six decades. While BHVs, taken from animal tissue, show improved hemodynamics, their durability is limited, whereas MHVs can last a patient's entire lifetime but require lifetime anticoagulation medication to reduce thrombotic complications. Future Polymeric HVs (PHV) hold the potential for enhanced durability compared to BHVs, while potentially avoiding the necessity for anticoagulation therapy that MHVs demand. However, the problem of flow-related thrombosis in PHVs remains a critical challenge. Generally, flow-related thrombosis complications can be avoided by altering the flow field around the PHV, such as reducing vortices and circulatory hemodynamic structures as well as decreasing shear stresses which can lead to platelet activation. Inspired by passive flow control in nature and in the aerodynamics industry, where manipulation of fluid flow via a small configuration change provides large engineering benefits in swimming or flying, we aim to use a flow control strategy to optimize blood flow through PHVs. More specifically, in StreamlineValve, we present a new, patented, PHV that is designed to alter the flow field around the valve in a manner that reduces the primary factors contributing to coagulation on PHVs. We have already successfully demonstrated this concept in vitro in a modified MHV. In this PoC, we propose to extend this to the future of prosthetic valves via a flow controlled PHV that can be implanted via a simple transcatheter procedure avoiding undesired surgical procedures. Altogether, StreamlineValve represents a paradigm shift in the realm of prosthetic HVs, offering the potential to enhance valve longevity, quality of life, and patient safety.
Democratizing AI for cognitive process automation (DeepOpinion)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 2785850.0
EU funding (EUR): 1950095.0
Participants: 1
Project status: CLOSED

DeepOpinion is a B2B SaaS platform for end-to-end automation of unstructured text- and document-heavy processes that has been developed as a no-code platform, empowering end-users and automation experts to build human-level AI skills that can be integrated into making existing bots “intelligent” bots or used to create end-to-end intelligent workflows from scratch. DeepOpinion is based on a proprietary ML engine created over 4 years of R&D for automated deep learning for Natural Language Understanding (autonlu.com) and Intelligent Document Processing, automatically training the best AI models for data sets in 100+ languages. DeepOpinion consists of 2 core components: 1) Cognitive Skill Builder (AI Builder) & 2) Flow Builder. The Skill Builder is a no-code interface used to create various custom cognitive skills (AI skills, NLU, IDP tasks) to infuse into existing bots, or to create “smart bots”, built on AutoNLU. The Flow Builder allows customers to create new automation workflows.

Keywords: process automation,usage based pricing,fintech,no code b2b saas platform,automated machine learning,text and document information extraction,intelligent process automation,intelligent cognitive process automation,autonlu engine,cognitive skill builder,cognitive automation builder,human like workflow automation,api,automation,seamless integration,natural language understanding autonlu,automated deep learning,machine learning,automl,customer oriented industries,opinion mining,automated topic detection,automation application,b2b saas platform
Unravelling the epicardium contribution to disease mechanism for treatment design in arrhythmogenic cardiomyopathy (IMPACT-Hop on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 17.0
Total project cost (EUR): 493468.75
EU funding (EUR): 493468.75
Participants: 2
Project status: CLOSED

Arrhythmogenic Cardiomyopathy (ACM) is a genetic disease with no effective treatment available, predisposing patients to ventricular arrhythmias and sudden cardiac death. ACM is characterized by progressive cardiomyocyte loss and fibrofatty replacement, often starting in the epicardium. While epicardial abnormalities may represent early ACM signs, the mechanisms driving fibrofatty tissue accumulation remain unclear. Also, a major challenge is that most ACM animal models do not naturally develop the cardiac adipose tissue seen in humans and many in vitro heart models lack the epicardium layer in its complexity. With IMPACT-Hop On, AccelBio will bring a unique and complementary humanized heart organoid model (Epi-HO) to the IMPACT EIC Pathfinder consortium, which replicates the epicardium-myocardium structure observed in the adult human heart. Generation of Epi-HO carrying ACM mutations (ACM-Epi-HO) will create a new Work Package (WP10) focused on the epicardial–to–fibro-fatty transition. ACM-Epi-HOs will be generated and characterized to uncover new mechanisms of action, biomarkers and therapeutic targets. New molecular and structural data will be incorporated into previous IMPACT tasks, feeding the AI-assisted comparative analysis of ACM models and contribute to patient stratification. ACM-Epi-HOs will also aid in identifying and validating therapeutic compounds to prevent epicardial abnormalities. AccelBio’s expertise on translational research and the uniqueness of its Epi-HO model will strongly potentiate IMPACT’s outcomes and accelerate the development of first in class ACM therapies. Additionally, through organization of research, business and society-oriented activities, AccelBio will potentiate IMPACT’s dissemination and exploitation plan. Conversely, with IMPACT-Hop On, AccelBio will gain new competencies in project management and coordination, increase its participation in transnational projects and reinforce its network within EU biotechnology R&I ecosystem

Keywords: arrhythmogenic cardiomyopathy human heart organoids epicardium drug discovery biomarkers therapy