Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translational Science for Vascular Inflammation and Remodelling (TRANSVIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria,United Kingdom,Netherlands,Ireland,United Kingdom,Netherlands
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 2677767.0
EU funding (EUR): 2677767.0
Participants: 6
Project status: CLOSED

The rapid advance of biology is providing new insights into the causes of some of today’s most pressing medical problems as well as huge opportunities to develop and evaluate novel and more effective treatments. The challenge is to exploit these advances effectively and this will require a new breed of translational scientist with expertise in a specific discipline coupled with a broad understanding of disease processes. We aim to address this need by creating an Initial Training Network (ITN) to provide Early Career Researchers (ECR) with the required skill-set. The ITN has clear scientific focus on endothelium and its interaction with leucocytes as a therapeutic target for severe disease. It has been designed around four internationally recognized academic partners and three Level 1 Industry partners - one an SME. They are: Medical University of Vienna, Austria (Rees/Kain/Kerjaschki); University of Cambridge, UK (Smith); Leiden University Medical Centre, Netherlands (Daha/van Kooten); and Trinity College Dublin, Ireland (O’Neill). The Industry partners are Astra Zeneca, UK (Jürgensmeier), Baxter Austria (Kirschbaumer) and Hbt Netherlands (Rutjes). A second SME, Biolution, Vienna (Grünert) will contribute to training as a Level 2 partner. The training program will equip 11 ECR and 1 ER with considerable expertise in an aspect of translational science and an understanding of how to use it in academia or industry. It has five elements: (i) rigorous research training in a specific translational discipline in one of the partner’s laboratories but with attachments to others; (ii) broader training in of translational science through taught courses, regular scientific meetings and secondments to industry; (iii) a training program in the generic skills for scientists; (iv) specific training in the particular skills required by scientists working in industry; and (v) a unique program to facilitate mobility of scientists within Europe.

Keywords: health sciences,medical science,translational science,kidney,inflammation,angiogenesis,therapy
Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Israel,Netherlands,Netherlands,Germany,Germany,France,Italy,Germany
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 2838539.06
EU funding (EUR): 2838539.06
Participants: 15
Project status: CLOSED

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly develop researchers within the EU who have the research skills required to make a real contribution to cancer treatment. The need for quality researchers is particularly acute within the emerging interdisciplinary field of Adoptive Cell Therapy. This promising advance in cancer treatment is based on the exploitation of tumour immunology and genetic technology and built on the specific ideas and techniques originally proposed by the European and Israeli scientists who are members of the ATTRACT network. To facilitate further development within the field of adoptive cell therapy, it is crucial that a co-ordinated and intersectoral approach (combining both the research community and industry) is taken, an approach that broadens the portfolio of skills currently retained within the EU research community. Through the integration Europe’s undisputed leaders in the field of adoptive cell therapy established in the 2005 FP6 ATTACK project, the ATTRACT network aims to foster the development of a pool of ESR’s and ER’s by equipping them with the multidisciplinary and complementary skills needed to not only initiate further advances in the field but to become future leaders within the field of adoptive cell therapy for cancer treatment. Such skills are global in demand making each researcher a highly desirable candidate for employment and very mobile across the different career domains.

Keywords: adoptive cell therapy,cancer,immunotherapy,gmp cell processing,clinical
Integrated Interventional Imaging Operating System (IIIOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Norway,Germany,Netherlands,Germany,Czechia,Germany,Sweden
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 3712345.0
EU funding (EUR): 3712345.0
Participants: 12
Project status: CLOSED

The scope of the present consortium is to provide technology and training for the integration of ultrasound and biophotonics based imaging with magnetic resonance imaging (MRI), Computed Tomography (CT) and Positron Emission Tomography (PET) to define the specs of an Integrated Interventional Imaging Operating System (III OS) aimed at minimal invasive treatment of common life-threatening disorders, e.g., cancer, cardiovascular disease and structural heart defects. Effective therapy of these conditions will require a range of safe surgical and interventional devices used with the necessary visualization and tracking under real-time image guidance. The consortium includes a critical mass of industrial and university research institute partners with high expertise in design, development, and manufacture of these devices and instruments. To ensure medical the safety and economical usability of the system and to allow an optimal integration into the future hospital workflow, 6 university hospitals will contribute their clinical and administrative expertise to the consortium in the fields of Interventional Radiology/Cardiology, Anaesthesia, Oncology, General and Cardiovascular Surgery and preclinical Image guided procedures. The consortium of the IIIOS research and training process includes two Biomedical Technology Societies: DGBMT and SMIT&amp;MEDIS Foundation in Rumania providing expert networking and conference organization. The is involved in the consortium and will play a key role in the exchange of knowledge and expertise to the new member states of the EU through hosting conferences such SMIT 2009 in Sinaia (www.smit2009.com).

Keywords: health sciences,anaesthesiology,surgery,medical physics
Biology of Liver and Pancreatic Development and Disease (BOLD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Belgium,France,United Kingdom,Germany,Greece,Spain,United Kingdom,United Kingdom,Sweden,Hungary
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-09-01
End date: 2013-08-31
Duration (months): 48.0
Total project cost (EUR): 3719150.0
EU funding (EUR): 3719150.0
Participants: 12
Project status: CLOSED

Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. Objectives: 1) To provide a broad multi-disciplinary approach to liver and pancreatic development and disease which will ensure a solid foundation in research technology and methods. 2) To offer a number of multi-centre and cross-sector projects. 3) To organize regular meetings which will provide task-specific and complementary training in skills essential for career development. Implementation: 1) involvement of highly successful research leaders and groups (with expertise in different disciplines including systems biology and bioinformatics, developmental biology, genomics, genetics and epigenetics, cell biology, engineering and drug development) in design and running of this programme will ensure the cutting edge research methodology and multidisciplinary approach to training. 2) Each research project will involve minimum two partners. 3) Partners will alternate in organizing network meetings which will include laboratory courses, single-topic conferences and network workshops. 4) The experienced researchers recruited to the network will spend more time in the industrial setting and have more leadership training and responsibilities.

Keywords: natural sciences,chronic diseases,rare diseases,laboratory animal science,measurement technology,modelling tools,bioinformatics,diabetology,biochemical technology
Multi-Gigabit European Research and Education Network and Associated Services (GN3) (GN3)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: United Kingdom,Netherlands,Austria,Serbia,Slovenia,Bulgaria,Croatia,Czechia,Cyprus,Germany,Estonia,Italy,Greece,Ireland,Israel,United Kingdom,Lithuania,North Macedonia,Montenegro,Denmark,Poland,France,Romania,Latvia,Netherlands,Switzerland,Türkiye,Malta,Belgium,Portugal,Hungary,Spain,Luxembourg,Slovakia
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-04-01
End date: 2013-09-30
Duration (months): 54.0
Total project cost (EUR): 177677472.0
EU funding (EUR): 93000000.0
Participants: 35
Project status: CLOSED

The objective of this proposal is the creation of a leading edge network supporting a much enhanced range of both network and added value services targeted at end-users across the GÉANT service area. A principal goal will be to create a portfolio of seamless multi-domain services. In contrast to its predecessor, GN2, much more emphasis is placed on service development and service introduction. Initiatives are planned in the areas of multi-domain network service operation, where it is planned to organise quick and efficient provisioning of advanced services, develop operational support crossing management domains and security to ensure service integrity and protection of network resources. This will be complemented by the development of end-user services in a federated environment which will focus on the creation of generic “meta-services”, particularly in the context of security as well as further developments in the area of Roaming Services. Individual Tasks within the Joint Research Activities (JRAs) will be of shorter duration and more targeted than in GN2. The initial JRAs will deal with a critical analysis of future networking technologies as well as research into new services both from the point of supporting the development of new services as well as researching into enhancements to the emerging service portfolio (monitoring, mobility and resources management). These will be supported by Networking Activities (NAs) dealing with both internal and external project communications. A particular emphasis of the NAs will be to support and encourage the take up of services among end-users by working closely with NRENs. The need to develop this theme co-operatively with other world regions is recognised by the inclusion of an activity specifically targeted to achieve this. A committee of the NREN proposers (NREN Policy Committee) deals with overall policy and a Project Board (Executive Committee in GN2) oversees its implementation. This will be strengthened by the cr

Keywords: network research academic education nren europe european development
Role of Calcineurin alternative splicing variant CnAbeta1 in stem cell biology and cardiac development (CARDEB1)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The heart is the first organ to form and it is essential for blood distribution during embryogenesis. Congenital heart malformations are the most common birth defect in humans, present in 1 % of the human population worldwide. The calcineurin splicing variant CnAbeta1 is expressed in stem cells, precursors and developing tissues and its expression decreases during tissue maturation. We aim to determine the role of CnAbeta1 during different stages of embryonic development. Aims: 1. Identify the role of CnAbeta1 in embryonic stem (ES) cell biology: We will knock down CnAbeta1 expression in ES cells using siRNA constructs and study their self-renewal and differentiation capacity. 2. Study embryonic development of transgenic mice in which CnAbeta1 expression is reduced ubiquitously: We will generate transgenic mice in which CnAbeta1 expression will be knocked down ubiquitously by overexpression of a specific CnAbeta1 shRNA. We will identify morphological defects and study target tissues using immunohistochemical and biochemical approaches. 3. Determine the role of CnAbeta1 in cardiac development by using conditional knockdown mice in which CnAbeta1 expression is reduced specifically in the heart: We will overexpress CnAbeta1 shRNA specifically in the heart from E8.0 onwards by using Cre/Lox technology. We will study the effects of CnAbeta1 knockdown by immunostaining and biochemical approaches and study cardiac function in the adult heart by using echocardiography and telemetry. Transcriptional and phosphoprotein profiles will be analyzed using DNA and protein microarrays. 4. Study the role of CnAbeta1 in the epicardium during embryonic development and in adult heart: We will overexpress CnAbeta1 shRNA specifically in the epicardium using Cre/Lox technology. Mice will be analyzed as in Aim 3. We will study the ability of epicardium-derived cells (EPDC) to migrate and undergo EMT in the absence of CnAbeta1.

Keywords: cardiology,genetically modified organisms,developmental biology,molecular biology
Isometric actions (ISOMETRIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The increasingly demanding challenges in our society require the development of innovative ideas. These ideas often originate from mathematical models of phenomena in natural and life sciences, in medicine and business, in technology and engineering, in manufacturing and design, and in other areas. Many of these models lead to geometric structures describing the phenomena precisely or, in most cases, approximately. Innovation and scientific development depends upon a thorough understanding of these geometric structures. The aim of this project is to investigate geometric structures from the viewpoint of their symmetries, and to characterize them by some distinguished features. We are interested in the geometry of those submanifolds that arise as orbits of isometric actions on Riemannian manifolds. More precisely, we plan to investigate the following problems: - Classification of isometric actions on Riemannian manifolds. We will focus on polar and hyperpolar actions, or cohomogeneity one actions, that have attracted much attention over the last few years. - Study of the geometry of the orbits of isometric actions on Riemannian manifolds. - Characterization of the orbits of isometric actions by means of their geometric properties. The objectives of this proposal will be achieved by using techniques recently developed by the applicant and his previous host group and by developing a computer program of symbolic calculus, a matter in which the applicant is experienced. This proposal suits the objectives of the action: it promotes interdisciplinary relations (isometric actions have successfully been used for the construction and investigation of special structures which have substantial interest in physics; we use programming techniques to handle symbolic calculations), reinforces international relations and provides the applicant with the chance of a lasting professional integration in a research institution.

Keywords: physical sciences,mathematics,geometry,differential geometry
Academic Dishonesty: the Non-Survey Approach (ACADIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-03-31
End date: 2012-03-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

In this project I would like to contribute to our understanding of extent, determinants and possible countermeasures against violations of academic integrity. I will focus on research fraud as well as cheating and plagiarism among undergraduates. There are two major contributions. First, I develop and implement a number of new non-survey (thus non-hypothetical) techniques. This is important, because vast majority of past studies used questionnaires. Albeit useful, this methods has limitations; in particular, we can never be sure to what extent our subjects report their (and their colleagues') wrongdoing truthfully. Instead I will investigate exam cheating in undergraduates by means of a field experiment, in which examinees, unaware of being subject to study, will be reminded, depending on the treatment, that cheating may bring about serious sanctions, that it is unethical etc. Actual cheating behavior will be (albeit imperfectly) observed by means of indexes of similarity of responses to exam questions (Frary et al., 1977). Prevalence as well as social and cultural determinants of plagiarism will be investigated using data obtained from Turnitin - an international provider of text similarity detection tools. Two types of violations of research integrity will also be investigated (using real data from a large body of published work in social sciences): fraudulent and "strategic" reporting of statistical results and insufficient scrutiny in theoretical work, resulting in flaws in models. I also plan to run a lab study aiming at finding which countermeasures (sanctions, moral appeal, “honor codes”…) are likely to work. The second contribution is that I plan to include in my studies the under-researched Eastern European countries, in which, partly because of recent transformation of socio-economic transformation (resulting i.a. in dramatic broadening of student base and certain ambiguity of social norms after the institutional clash) exam cheating is a serious issue.

Keywords: research integrity,research fraud,ethics in social sciences,methodology of social sciences,university eductaion,cheating,plagiarism,deception
Structural studies of type III secretion system virulence protein BteA (T3SSBTEA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-01
End date: 2013-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Bordetella pertussis, B. parapertussis and B. bronchiseptica are Gram-negative bacteria that colonize the respiratory tracts of mammals. B. pertussis has adapted exclusively to the human host and is known to be the causative agent of whooping cough (pertussis). Bordetella bacteria use the type III secretion system (T3SS) to establish persistent colonization of the trachea and to modulate the host immune response. They encode a highly conserved type III secretion effector protein, BteA, which is responsible for the induction of rapid, non-apoptotic death in a wide range of mammalian cells. BteA, the only type III effector that has been identified in Bordetella, shows no homology with any other type III effectors. The overall goal is to determine BteA structure and to elucidate its involvement in mechanisms leading to cell death. Our specific aims are: 1. To express, purify and determine the 3D structure of BteA from B. bronchiseptica. 2. To analyze BteA structure and determine its functional sites and to determine the ability of BteA to bind ligands. 3. To locate BteA interacting proteins in the eukaryotic host cell by using BteA as bait and thus determine i) protein function; ii) the structure of BteA-target molecule complexes. Cutting-edge technologies will be used for structure determination and functional analysis of clean protein samples (X-ray crystallography, structure prediction and functional point mutations) and for the investigation of ligand binding and host cell interactions (pull-down assays, mass spectrometry and surface plasmon resonance). The outcome will be new targets for antibiotic development and a better understanding of protein-protein interactions, cell targeting and cell death. The research will enhance EU competitiveness in structural biology and the life sciences and in the long term will contribute to public health (treatment and prevention of whooping cough).

Keywords: health sciences,bacteriology,structural biology