Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantifying the impact of the urban biosphere on the net flux of CO2 from cities into the atmosphere. (URBANCO2FLUX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-07
End date: 2018-09-06
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

Due to the offsetting effect of the urban biosphere resulting from the photosynthetic uptake of CO2 by plants that are often well watered and fertilized, the precise impact of urban emissions on the global burden of GHGs is challenging to quantify. Green-space initiatives that increase the vegetative coverage of the landscape, and therefore the productivity of the urban ecosystem for sequestration of CO2 are often proposed as GHG reducing strategies, despite there being very little quantitative evidence for the effectiveness or efficiency of such strategies. Uncertainty in the time scales for respiration of carbon previously taken up through photosynthesis obscures the picture even further. Meanwhile, as the modern urban landscape is continually evolving, with green spaces and parks becoming a more integral component and with suburbs expanding outward from city centers into previously rural, agricultural, and natural areas, it is apparent that we lack the scientific understanding of how best to implement planning strategies that minimize the impact of such changes on climate. I have expertise in urban metabolism and quantifying carbon footprint at city level, however I lack the scientific knowledge required to understand and quantify the impact of the (urban) biosphere on the net flux of CO2 from cities into the atmosphere. UC Merced, presently leading a 4-yr NSF project in atmospheric modeling of COS to understand carbon cycle processes in urban ecosystems, provides the ideal training ground for me to gain the skills necessary to reach excellence in this multi-disciplinary effort to making our cities more sustainable. The project aims to answer the following questions: • What is the global impact of urban/suburban ecosystems on atmospheric CO2? • How will future shifts in land-use types and management practices in densely populated areas influence surface atmosphere fluxes of CO2?

Keywords: urban biosphere,inverse cos modeling,urban co2 fluxes
Embodied and Abstract Concepts in Sensory-motor Deprivation (EACISD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 263385.0
EU funding (EUR): 263385.0
Participants: 2
Project status: CLOSED

How is information organized in the brain? Does our understanding of everyday concepts rely on our perceptual experience, and our ability to sense them? And can this uncover how abstract information is coded in our brains? These puzzles are at core of cognitive neuroscience and brain organization. Two major theoretical bodies differ in their account of neural concept organization: Classical cognitive theories propose that concepts are symbolic and non-sensory, and are further linked to sensory-motor aspects, whereas embodied cognition theories (e.g. mirror neuron system theory) postulate that concepts are represented only in a sensory-motor manner, and representations depend on the ability to simulate, re-enact, its perceptual process or action. To address this contradictory account of concepts organization, a systematic interdisciplinary neuroimaging investigation will be conducted in a combination of special populations, each deprived from birth from an entire sensory modality or ability. The neural correlates of impossible-to-embody concepts will be studied in congenitally blind (e.g. rainbow), deaf (e.g. jazz) and ULD subjects (born without functional hands; e.g. manually handles tools). Brain responses will be analyzed using multiple, state-of-the-art neuroimaging decoding techniques to reveal brain areas representation content and dependence on sensory experience. The neural networks of such concepts will be charted, to investigate the link between abstract thought and sensory inputs. A novel non-linear measurement method to quantity the richness of representations will be developed and applied to the sensorily-deprived groups, to map the dimensions related to specific sensory modalities. At the final stage, these methods will also be applied to study the developing brain in children. The findings have the potential to revolutionize our understanding of brain organization and pave the road towards rehabilitation of multiple sensory and cognitive deficits.

Keywords: concept knowledge,abstract,concrete,vision,audition,motor,neuroscience,sensory,deprivation,brain organization,embodied cognition,development,plasticity,autism
The Digest and the Exploitation of the Countryside in the Western Roman Empire (2d cent. BC-3rd cent. AD). Evidence of the water control (DEXCORE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Every aspect of the ancient world depended on the control and exploitation of the countryside, but scholars have until recently failed to engage with an abundant and detailed material on the subject: the legal texts of the Digest. The thought of the Roman jurists constituted a powerful model for all the minor and local institutions and legal documentation reveals not only rules, but also actual practices and issues of unquestionable historical interest. Amongst the significant amount of legal texts concerning the countryside, the issues of water sharing and that of erosion and flood risks management are particularly well represented, constituting a key element of an essential aspect of the ancient economy, i.e. the agricultural production. However, an overall underestimation has led to a serious insufficiency of methodology concerning these texts, an evident obstacle to its exploitation in a historical perspective. This research proposes to demonstrate how relevant the study of Roman law is for our knowledge of the Roman countryside, by confronting the strikingly unexplored jurisprudential documentation with more traditionally exploited archaeological and environmental sources. The focus on water control is motivated by a will to concentrate on a crucial condition of the exploitation of the countryside, which has raised sufficient interest from the ancient jurists themselves, as well as from the scholars in the past decades, so as to generate enough primary and secondary sources for us to consider. The objective is twofold: first, to establish a clear and consistent methodology for the historical study of the jurisprudential sources; second, to apply it to case studies in order to produce new insights into a fundamental issue of the Roman world.

Keywords: ancient agriculture,economy,water management,roman law,digest
Integrated cyber-physical solutions for intelligent distribution grid with high penetration of renewables (UNITED-GRID)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Sweden,France,France,France,Netherlands,Netherlands,Netherlands
Call: Next generation innovative technologies enabling smart grids, storage and energy system integration with increasing share of renewables: distribution network (H2020-LCE-2017-SGS, 2017)
Start date: 2017-11-01
End date: 2021-04-30
Duration (months): 42.0
Total project cost (EUR): 4007085.0
EU funding (EUR): 4007085.0
Participants: 12
Project status: CLOSED

UNITED-GRID aspires to be the arrow-head within “Integrated cyber-physical solutions for intelligent distribution grid with distributed energy resources” and addresses the challenges in the “competitive low-carbon energy", relevant to next generation of active distribution grids. UNITED-GRID will develop a tool-box with technologies enabling at least 80% renewable-based energy production on an annual basis, with an increased reliability performance of 50%, while decreasing grid losses by 10%. The developed technologies include e.g. solutions for real-time system awareness and control, short term generation and load forecasting, setting-less protection schemes and new business models. The tool-box will be integrated into a professional system ensuring interoperability and smooth integration with existing EMS/DMS on the market. To enhance future impacts, at least 2/3 of novel solutions which have been positively validated will have an agreed and financed development processes for the next TRL level beyond the project. The project team has been selected carefully and has proven R&I, demonstration and deployment capabilities as well as established regulatory and policy channels. The team includes experienced research organisations (SP, TU/e, CEA, and Chalmers), 3 DSOs, a DMS provider and expert SME partners to ensure the exploitation of the developed solutions. To further enhance the deployment towards a low carbon energy society, the project will together with at least 20 market actors define pathways to navigate in the rapidly changing energy environment. Furthermore, at least 25% of the test-pilots will sign a letter of commitment to execute parts of the developed pathways. The real-life demonstrators, covering more than 80% of European market conditions, are provided by the project partners in-kind to an estimated value of €4.1M. With the requested EC contribution of €4M, the project encloses €8M, matching the UNITED-GRID projects ambitions and objectives.

Keywords: cyber security,real time monitoring,control,protection,renewable,intelligent distribution grid,congestion management,pathways,energy market,business model,self healing,autonomous,adaptive
COnversational BRAins (COBRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Belgium,Slovakia,Sweden,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 4009608.0
EU funding (EUR): 4009608.0
Participants: 9
Project status: SIGNED

COBRA aims to train the next generation of researchers to accurately characterize and model the linguistic, cognitive and brain mechanisms deployed by human speakers in conversational interactions with human interlocutors as well as artificial dialog systems. It relies on a cross-sectoral international network of 11 world-level academic research centers and 4 non-academic partners with 3 fast-developing SMEs and 1 world-level company. The partners' unique combined expertise and high complementarity will allow COBRA to offer 15 ESRs an excellent training programme as well as strong exposure to the non-academic sector in the emerging field of conversational brains. Training will cover scientific and technical skills, from the joint monitoring of brain and physiological activities in two or more people talking to each other to making multi-language databases, resources and findings available in open access, as well as transferable skills. The ESRs will conduct experimental and corpus studies on the alignment and prediction processes that make conversation between people both easy and fluent, across a large variety of communicational settings and in different languages, to better understand how these processes contribute to setting up brain-to-brain coupling relationships. Collaborative work with non-academic partners will foster the development of more effective and socially acceptable text-to-speech synthesizers, artificial dialogue systems, and social humanoid robots with high-level conversational skills. The project will open new career perspectives for ESRs with interdisciplinary training in language sciences, neuroscience and dialog systems on a very fast-growing digital market. COBRA’s training programme will also have major societal implications as it will concern aspects of the European citizens’ everyday life, from spoken interactions with machines to conversing in a non-native language.

Keywords: conversational interactions,alignment and prediction in dialogue,brain and cognitive,underpinnings of spoken language,intelligent robotics,artificial dialogue systems,secondlanguage,learning
CardioReGenix: Development of Next-Generation Gene Therapies for Cardiovascular Disease (CardioReGenix)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Finland,Belgium,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovation platforms for advanced therapies of the future (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 14839773.5
EU funding (EUR): 14839773.5
Participants: 13
Project status: SIGNED

WHO estimates 17.7 million people die each year from cardiovascular disease (CVD), an estimated 31% of all deaths worldwide. While progress with conventional treatments is making incremental gains, there remains a need to develop innovative therapeutic approaches. Gene therapy has gained significant momentum, mainly for treatment of rare monogenetic diseases. Marketing authorization for gene therapy products has not impacted diseases such as CVD. Recent, deeper understanding of the molecular/cellular mechanisms of CVD and technology associated with more efficient and safer gene therapy vectors has allowed new opportunities for development of next-generation ATMPs for CVD. CardioReGenix focuses on technological innovations for the treatment of CVD, in particular heart failure and myocardial ischemia. We aim to overcome bottlenecks in gene therapy for CVD by (i) maximizing cardiac-specific gene expression; (ii) maximizing cardiac-specific gene delivery; (iii) reducing adverse immune responses; (iv) optimizing manufacturing for research and clinical-grade ATMPs ; (v) validate new promising targets using in vitro and preclinical models; (vi) undertaking first-in-man studies; (vii) developing and implementing an exploitation and valorization strategy with strong EU SME involvement. CardioReGenix is a high risk/high gain project supported by robust preliminary data and multi-disciplinary consortium harnessing know-how in vector development, GMP manufacturing, preclinical and clinical cardiology, regulation of ATMP and liaising with EMA, business development and clinical translation. CardioReGenix will (i) strengthen Europe's competitive position in gene therapy development for CVD; (ii) improve the prospect of successfully treating patients suffering from CVD by gene therapy and (iii) develop and refine the latest gene therapy platforms that go significantly beyond the state of the art.

Keywords: cardiovascular disease,ncrna,gene therapy
MULTI-SCALE MODELLING FOR TURBOMACHINERY FLOWS USING HIGH-FIDELITY COMPUTATIONAL DATA (TSCALE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 257209.92
EU funding (EUR): 257209.92
Participants: 2
Project status: SIGNED

The flow dynamics within turbomachinery flows are complex and still not fully understood. Such flows are rich in turbulent phenomena driven by high levels of unsteadiness. Despite much progress we are still unable to reliably predict many of these phenomena (e.g. wake interactions, transition, separations) using standard modelling techniques which hinders further aero-engine efficiency improvements. To investigate these phenomena, researchers are employing high-fidelity techniques both in experiments and in computations, e.g. direct numerical simulations. These techniques give unprecedented resolution and a wealth of data but extracting knowledge and distilling it into reduced-order models applicable to a wide range of flows is challenging, thus limiting their impact. The objective of this project is to address this limitation by adapting a theoretical framework of data-driven flow decomposition to turbomachinery flows. This methodology will be used to study inter-scale energy transfers between the different flow dynamics within the multi-stage compressor. The project aims to discern between scales contributing towards the turbulence production, dissipation and those regulating the flow of energy down the turbulence cascade. The analysis will be facilitated by combining multiple high-fidelity datasets from computations at engine representative conditions. The primary goal of the project is to establish a new paradigm for industrial flow modelling that utilises all the information embedded within the 3D unsteady flowfield. Consequently, a new set of low-order models will be derived, each catering to a different range of scales present in the compressor flowfield. The project will leverage the expertise of three world-leading groups in high-performance computing data decomposition and turbomachinery modelling. Results of this project are expected to provide much needed insight into multi-scale interactions in complex industrial flows such as those of aero-engines.

Keywords: high performance computing,turbomachinery,multi stage compressors,turbulence,non equilibrium behaviour,data decomposition,multi scale modelling,reduced order models
Investigating the effects of immunogenic chemoradiation in shaping the immune landscape of esophageal cancers (IC_IL_EC_2017)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-05-19
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Esophageal carcinoma (EC) is among the top 10 deadliest cancers worldwide. The current standard therapy for ES is neoadjuvant (pre-operative) chemoradiation (NACR) followed by surgery. However, only 30% of patients achieve a complete pathological response (CPR) and long-term survival. Understanding the mechanisms of response to NACR is hence pivotal to better stratify patients and inform the design of more efficacious therapies. Evidence from some tumors suggests that NACR is “immunogenic” and stimulates anti-cancer immune responses, which may contribute to the longterm effects of successful treatments. Tumor neo-antigens, generated by somatically mutated cancer genes, have been recently implicated in the activation of the most efficient anti-tumor T cell response capable of controlling tumor progression, induced by immune checkpoint blockade immunotherapy. This raises the question as to whether clinical responses induced by NACR in a fraction of ECs may be linked to the stimulation of clinically relevant T cell responses against tumor neoantigens, implying that activating tumor immunity in the non-responding ones may improve clinical responses. Objective of this proof-of-concept study is hence to address this question through the implementation of a high-throughput platform to assess neoantigen-specific T cell responses in ECs in the course of NACR.

Keywords: tumor neo antigens,esophageal carcinoma,high throughput epitope screening,tumor specific t cells,cancer immunotherapy
The combinatorics of KPZ at positive temperature (KPZcomb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-02
End date: 2023-09-01
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The Kardar-Parisi-Zhang equation (KPZ) was introduced in 1986 as a universal model to capture statistics of a wide range of physical phenomena such as growth of interfaces or turbulent fluids. Remarkably fluctuations of this class of systems fall out of the scope of the classical central limit theorem. Understanding these phenomena has driven a tremendous activity in rigorous mathematics leading to groundbreaking theories or even to whole new fields such as that of Integrable Probability, where this proposal belongs. Since the seminal work of Johansson (1999), it is understood that systems in the KPZ class are governed by distributions coming from random matrix theory. So far, a framework with clear "determinantal structure" has been created to tackle models at "zero temperature". Progress in positive temperature setting, including the KPZ equation, only came during the last decade. Insights from many different fields (combinatorics, symmetric functions, etc) into probability, allowed to treat one-point statistics of certain systems at positive temperature. In all instances a mysterious determinantal structure, whose origins elude understanding, appears to govern (so far only) one-point statistics. This project aims to reveal the deep foundations of integrability of KPZ models at positive temperature and extend its scope. This will allow to settle the solvability in situations that are currently out of reach such as restricted spatial geometries and multi-point correlations. To achieve this we will follow a new route producing combinatorial mappings of positive temperature systems to purely determinantal ones. Our approach will make novel uses of methods from combinatorics and integrable systems (via the Yang-Baxter toolbox) and will create new dynamics linking integrable systems (such as box-ball system) to the KPZ universe. At the same time our probabilistic insights will give rise to new methodologies and will answer old questions from algebraic combinatorics

Keywords: integrable probability,kpz universality,exactly solvable systems,young tableaux,symmetric functions,rsk correspondence,random matrices