Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Model-based Data Analysis of Transcription and Splicing (MoDATS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-05
End date: 2018-01-19
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Gene expression is the fundamental process that in all cells produces functional protein from a genomic DNA template using a messenger RNA (mRNA) intermediate. Eukaryotic gene expression involves transcription--the polymerization of mRNA--and splicing--the removal of non-coding regions from the mRNA. Recent evidence shows that nascent mRNAs are spliced while still being transcribed, not after completion of transcription, and that splicing machinery regulates transcription. This cross-talk complicates understanding of gene expression, as its mechanism and consequences are not understood. This project proposes using model-based data analysis, applied to multiple types of data, to study the kinetics of coupled transcription and splicing. Model-based data analysis is a statistical framework in which models are formulated as probability distributions encoding the stochastic interactions between components, including observed data. Knowledge of the underlying mechanism--here, biological--is used to quantify both the phenomenon, and the uncertainty resulting from partial knowledge and noisy observations. The need for such analysis is acute in modern biology: decades of molecular biology have yielded detailed information on specific molecules and pathways, and now next-generation sequencing (NGS) allows scientists to collect gigabytes of data on thousands of distinct molecules simultaneously. Yet, integrating these approaches is challenging: biologists struggle to analyze NGS data in ways that give insight into known--and previously unknown--biological mechanisms. Here, the model-based data analysis paradigm will be used to interrogate the interplay of transcription and splicing, using state-of the art data including time-resolved NGS measurements of RNA processing. Working with experimentalists, we will quantify the kinetics of splicing in constitutive genes by labeling nascent transcripts, and estimate the effect of splicing on polymerase elongation genome-wide.
The Populist Politics of Foreign Policy (PopulistFP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2020-09-30
Duration (months): 15.0
Total project cost (EUR): 140583.6
EU funding (EUR): 140583.6
Participants: 1
Project status: CLOSED

The emergence of new political cleavages and the increasingly polarized nature of political debate in democracies have profound implications for the politics of foreign policy decision making. International issues are becoming more salient in domestic politics. Meanwhile, rising populist parties on both left and right use international affairs to differentiate from mainstream parties and harness widespread public hostility towards the consequences of globalization. This suggests that partisan debates on foreign policy may be becoming more polarised. States may therefore find it increasingly difficult to pursue coherent foreign policy agendas, and it may be all the more difficult for the EU to build and sustain a coherent Common Foreign and Security Policy. Indeed, studies of European identity have highlighted a distinct divide across the EU over what Europe stands for: whether a beacon of universal democratic and human rights values, or a distinct ‘Judeo-Christian civilization’. Yet we lack a comparative picture of how the changing nature of political contestation in EU member state shapes how foreign policy questions are addressed by politicians and political parties. This project will fill this gap with a comparative analysis of partisan debates in Britain, France and Germany over intervention against the Assad regime, including in-depth interviews in each country, and comparing the results to a previous study of partisan debates over intervention in the Balkans in the 1990s. Through the project the ER will gain new skills in European politics, comparative politics, and systematic qualitative analysis, laying the groundwork for a career uncovering the changing politics of foreign policy, with outputs of significant value to scholars and practitioners.

Keywords: political parties,populism,european neighbourhood policy,syria,military intervention,islam and the west
Nanomedicine Doctoral Programme (NanoMedPhD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-09-15
End date: 2021-09-14
Duration (months): 60.0
Total project cost (EUR): 1255680.0
EU funding (EUR): 627840.0
Participants: 1
Project status: CLOSED

Biomedical research is one of the most important factors of economic development in modern societies, and a strategic element of major importance for the economic growth of the European Union. In particular, according to the White Paper to the Horizon 2020 Framework Programme for Research and Innovation of the Nanomedicine European Technology Platform, nanomedicine underspins a strong research and emerging industrial healthcare sector in Europe. Based on excellent academic research and innovative SMEs, nanomedicine will actively contribute to the three pillars of the Framework Programme Horizon 2020. It is known that the talent of people working in research is the headstone of any Science and Technology System. In this framework, Bionand has designed the Nanomedicine Doctoral Programme (NanoMed PhD), a new strategic programme to provide trans-national mobility for early stage researchers and offer them training activities that lead to the award of a doctoral degree in the emerging field of nanomedicine. The academic supervision will take place through tutors from the PhD programs of University of Málaga, and the scientific supervision of the research activity will take place in Bionand through its Principal Investigators. Bionand is the first national centre in Spain devoted to research in nanotechnology applied to health. Regarding the academic formation, the fellows will be enrolled in one of the four Doctoral Programmes related to this discipline, offered by the University of Málaga (UMA), which is the academic partner of this proposal. NanoMed PhD will last for a period up to 60 months and will launch an open call for fellowships for a total number of 8 incoming fellowships, aiming at hosting and tutorizing early-stage researchers within BIONAND in order to obtain a doctoral degree, since one of the main objectives as benchmark centre in nanomedicine, is to develope and support the research in this field throughout the Autonomous Region of Andalusia.. Researchers applying for NanoMed PhD incoming grants will be included into experienced research groups where they will be able to start a research career in one of the most emerging discipline.

Keywords: nanomedicine,nanodiagnostic,therapeutic nanosystems,regenerative nanomedicine
Ageing Diversity: LGBT* – Housing and Long-term Care (AgedLGBT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Existing studies about Lesbian, Gay, Bisexual, and Trans* (LGBT*) people have shown that those aged over fifty years of age (hereafter LGBT* seniors), are more likely to be childless, single and to live alone than their heterosexual peers. Housing, either with or without care, is a principal area of concern to LGBT* seniors, yet few studies exist in Europe that have directly addressed this topic. AgedLGBT* will make a significant contribution to knowledge about LGBT* seniors and housing by comparing and synthesizing the work of research projects conducted in Germany and the UK. It therefore represents a unique and valuable opportunity to understand this issue on a broader, international scale and significantly adds to the value and usefulness of European social science about LGBT* ageing. AgedLGBT* will use the data of two nationally unique research projects of the Alice Salomon University of Applied Sciences Berlin (D) and one conducted by the University of Surrey (UK) integrating these and adding to them across four interrelated work packages (WP): AgedLGBT* will compare and synthesize data from the research projects GLESA & GLEPA (D) and SAFE Housing (UK) to investigate similarities and variations about LGBT* seniors and housing (WP I). WP II comprises interviews with key experts, dealing with excluded minorities (such as LGBT* elders with lower income as well as trans* and intersexual seniors). A secondment at Stonewall Housing, UK, will support the realization of the interviews and strengthen the social work experience of the researcher. A social simulation model (WP III) for the cohorts of future LGBT* elders based on the analysis of data in WP I will provide new ways to hypothesize and understand the issue. Also the training in Agent-Based Modelling will be crucial for the researcher’s prospects. A symposium with experts (WP IV) and practitioners will be organised as a feedback platform with practical relevance and for looking beyond a LGBT* perspective.

Keywords: aging,diversity,lgbt,social inequalities
The power of grape extracts: antimicrobial and antioxidant properties to prevent the use of antibiotics in farmed animals (NeoGiANT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Argentina,Spain,Spain,Spain,Spain,Spain,Hungary,Belgium,Poland,Belgium,Czechia,Czechia,Portugal,United Kingdom
Call: Testing and demonstrating systemic innovations in support of the Farm-to-Fork Strategy (H2020-LC-GD-2020-4, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 9332246.49
EU funding (EUR): 8374688.42
Participants: 21
Project status: SIGNED

NeoGiANT is an innovative action coordinated by the University of Santiago de Compostela (Spain). NeoGiANT aims at developing a new set of products (animal feed, treatment products, sperm extenders) able to decrease the use of antibiotics on farmed animals and substitute synthetic preservatives. These new products, based on natural extracts, using an advanced isolation technique, will not only avoid the growth of microorganisms but also improve the health and welfare of the animals increasing profitability. The proposal is based on the use of biomass sources that can provide cost-effective, efficient and green solutions to obtain functional ingredients in sustainable circular economy production systems. The new products developed will be based on one extract of natural origin called e-Vitis (obtained from Vitis vinifera). e-Vitis is isolated using as raw material grape marc from the production of high quality white wines, that preserves, after the winemaking process, a significant load of bioactive compounds originally present in the grape. In order to obtain a multicomponent ready-to-use extract using green solvent extraction approaches NeoGiANT is going to apply an alternative methodology to conventional extraction, to disrupt the grape marc and extract the bioactive compounds. This innovative green technology is simple, the conditions required are mild (energy savings), and can be easily scaled-up. The advanced properties of the natural extract will provide antimicrobial and antioxidant protection to the animals improving their performance and serving as a prophylactic treatment. The target products to be developed will be designed to control a large number of infectious diseases of paramount importance in animal production, both in livestock and aquaculture. Moreover, the emergence of new antimicrobial resistances (AMR) will be reduced, and existing antimicrobial resistances will be better controlled.

Keywords: nantural antioxidant,natural antimicrobial,sperm extender,enhaced feed,bioactive ompounds,polyphenols,antimastitis syringue,animal s treatment international cooperation,open innovation
We help employees to adopt digital solutions (YesElf)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovakia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Only in EU, about 26 million active companies employing about 144 million employees invest billions of euros per year in onboarding process (training and support activities) and most of the companies are being digitally transformed. But being a digital organization means not only having digital products, services, and customer interactions but also needs a digital culture - which means proper mindset, expert network, and digital onboarding and training programs. By ignoring culture, an organization risks transformation failure and indeed that’s why almost 75% of the digital transformations fail. According to a Gartner study, 30% of tech jobs will be unfilled owing to digital talent shortfalls. According to recent BCG research even today, the biggest perceived technology challenge is not data security but a lack of qualified employees - only 25% of the digitally skilled people found in online recruiting databases today are working at large enterprises YesElf is an onboarding platform for providing a personalized and predictive step-by-step walkthrough for any enterprise software which makes employees more efficient (+10%) without any additional personal training at the right time by applying artificial intelligence and user behavior analysis. YesElf is improving the process of the employee onboarding, engagement and the adoption of digital products. Based on customers feedback our solution can reduce employee training costs by more than 50%, reduce support costs by more than 30%, increase employee productivity by double-digit number, provide smooth digital adoption and increase company income per employee. Brainware was founded in 2013 as a spin-off (sister) company of Seges (est. in 2006) with a strong focus on providing digital adoption and employee onboarding to large companies across Europe. YesElf has more than 300k unique monthly users from more than 30 European countries. Our team has been awarded by several start-up, innovation and entrepreneurship awards.

Keywords: user onboarding,digital adoption,user behaviour analysis,employee productivity
Augmented Approaches to Land 2 (AAL2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Germany,Germany,Ireland,Belgium,Switzerland,France,France,Czechia,United States
Call: Increased access to airports for low visibility mixed fleet operations (H2020-SESAR-2016-2, 2016)
Start date: 2018-02-01
End date: 2020-07-31
Duration (months): 30.0
Total project cost (EUR): 2963438.51
EU funding (EUR): 2110729.4699999997
Participants: 15
Project status: CLOSED

The proposed Augmented Approaches to Land 2 (AAL2) project addresses the full scope of the Call SESAR-VLD1-06-2016: Increased access to airports for low visibility mixed fleet operations. It builds upon the results from the former award winning SESAR project AAL, and will demonstrate augmented approach and landing operations based on the following SESAR solutions: GBAS (Ground Based Augmentation System) CAT II with CAT I airborne and ground equipment, enabling lower decision heights to CAT II minima (DH 100ft) (addresses hubs and medium size airports); EFVS (Enhanced Flight Vision System) to Land using Head Up /or Mounted Display, with operational credit down to 300 meters RVR in non- CAT II/III airports (addresses medium and small size airports). A very large partnership of aviation stakeholders has been brought together for this project. Altogether this VLD project will enjoy the involvement of very relevant stakeholders, giving the project high credibility of successful execution of the demonstrations, achievable results, good external communication, and collaboration. This partnership includes: 5 small/medium sized airports: Antwerp, Le Bourget, Payerne, Bremen, Perigueux; 2 large airports: Frankfurt and Newark; 6 Airspace Users : HOP !, EBAA, Lufthansa Group, Ryanair, Flying Group, and Zurich Insurance; 4 ANSPs: Belgocontrol, DFS, DSNA and Skyguide; 3 airframe manufacturers : Airbus, ATR, Dassault-Aviation; 2 avionics manufacturers : Honeywell, ELBIT; 7 regulatory bodies: BAF (German CAA), BCAA (Belgium CAA), DGAC (French CAA), EASA, FOCA (Swiss CAA), IAA (Irish CAA), LBA (German CAA); 3 European or Intergovernmental organizations: EASA, ESSP, Eurocontrol; 1 Instrument Flight Procedure Expert: DLR.
Control Over Noisy Communication Media (CONCOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 263385.0
EU funding (EUR): 263385.0
Participants: 2
Project status: CLOSED

Two of the fundamental theories within the discipline of electrical engineering are those of control and communication (along with its mathematical foundation, information theory [IT]). These theories have been studied extensively by mathematicians and engineers throughout the 20th century, and have gone separate ways. The primary objective of control theory is to stabilize and control the behaviour of a given dynamical system in a desired fashion by changing the system input according to its measured output (feedback). In this theory, adapting according to the feedback with minimal possible delay is of grave importance. The theories of communication and information deal with conveying reliably data over noisy media. IT seeks to determine the maximal reliable-communication rates possible, disregarding and often undermining delay and computational complexity. Communication theory attempts to approach the rates promised by IT using practical tools. In the past, control theory was mainly used in well-crafted closed engineering systems (e.g., car and aerospace industries). In the current technological era of ubiquitous wireless connectivity, the demand for control over noisy media is ever growing, enabling numerous new possibilities. Nonetheless, current theory and technology offer one of the following solutions: utilizing a communication scheme that improves reliability at the price of introducing a large delay and then trying to control the resulting system, or adapting solutions from classical control theory to control over unreliable media, known now as cyber-physical control. Indeed, due to the historic disjunction of these theories, no unified theory exists that determines the fundamental trade-off between communication reliability and rate, and delay and controllability. Developing such a unified “communication-control” framework can allow for a myriad of new exciting possibilities, such as remote surgery and self-driving cars, and is the aim of this research.

Keywords: tree codes,anytime reliable codes,cyber physical control,control over digital communication channels
A holistic approach to large-scale structure cosmology (BAHAMAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1725982.0
EU funding (EUR): 1725982.0
Participants: 1
Project status: SIGNED

The standard model of cosmology, the ɅCDM model, is remarkably successful at explaining a wide range of observations of our Universe. However, it is now being subjected to much more stringent tests than ever before, and recent large-scale structure (LSS) measurements appear to be in tension with its predictions. Is this tension signalling that new physics is required? For example, time-varying dark energy, or perhaps a modified theory of gravity? A contribution from massive neutrinos? Before coming to such bold conclusions we must be certain that all of the important systematic errors in the LSS tests have been accounted for. Presently, the largest source of systematic uncertainty is from the modelling of complicated astrophysical phenomena associated with galaxy formation. In particular, energetic feedback processes associated with star formation and black hole growth can heat and expel gas from collapsed structures and modify the large-scale distribution of matter. Furthermore, the LSS field is presently separated into many sub-fields (each using different models, that usually neglect feedback), preventing a coherent analysis. Cosmological hydrodynamical simulations (are the only method which) can follow all the relevant matter components and self-consistently capture the effects of feedback. I have been leading the development of large-scale simulations with physically-motivated prescriptions for feedback that are unrivalled in their ability to reproduce the observed properties of massive systems. With ERC support, I will build a team to exploit these developments, to produce a suite of simulations designed specifically for LSS cosmology applications with the effects of feedback realistically accounted for and which will allow us to unite the different LSS tests. My team and I will make the first self-consistent comparisons with the full range of LSS cosmology tests, and critically assess the evidence for physics beyond the standard model.