Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VALORISATION OF HARVESTED AGROFORESTRY BIOMASS WASTE AS FEEDSTOCK FOR VALUE-ADDED BIO-BASED SOLUTIONS AS A GREEN DEVELOPMENT PATHWAY (HARWASTING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Spain,Romania,Finland,Austria,Ireland,Denmark,Türkiye
Call: From silos to diversity – small-scale bio-based demonstration pilots (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 5566043.75
EU funding (EUR): 4991329.26
Participants: 17
Project status: SIGNED

HarWASTing aims to develop innovative business models based on circular economy (CE) principles to promote bioeconomy in rural areas, by implementing a set of scalable and replicable technological solutions to efficiently exploit underutilised biomass from forestry and agriculture to develop innovative and high-value products. These models will support sustainable management practices and will promote an efficient use of natural resources, reducing overall waste generation and post-harvest losses by implementing valorisation processes and fostering CE principles. To this end, a methodology will be implemented to collect, treat and revalorize biomass from forest and agricultural harvest, pruning waste and bioethanol process side-streams, respecting the cascade principle for biomass use. A one-fits-all technology, Hydrothermal Carbonization, for a higher energy efficient treatment of lignocellulosic biomass residues will be combined with Pressurized Hot Water Extraction and innovative post-treatment technologies, to develop high-value added products and avoid any non-valorised side-stream. The whole concept will be demonstrated at small-scale pilot, built-upon existing wood, food and bioenergy value chains to further strengthen their economic and environmental sustainability through synergistic interlinkages between them. Mediterranean, Boreal and Continental bioregions will be studied. The holistic concept is based on the central valorisation route of Hydrothermal Carbonizationand its solid product, hydrochar, that is converted into hybrid wood-hydrochar panels with less than 10% of bio-adhesive for special applications such as fire protection or electromagnetic shielding. A novel support AI-based digital tool for forecasting agroforest feedstock availability will be developed. Innovative digital passports will help to commercialize the panels and bioadhesives. The hydrochar will be offered on a new digital platform which also serves for networking and for publishing of best-practices.

Keywords: circular economy,business models,revalorization,agroforest wastes,biorefineries,forest,htc
Powering EU Net Zero Future by Escalating Zero Emission HDVs and Logistic Intelligence (ESCALATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Germany,Türkiye,France,Estonia,Belgium,Denmark,Finland,Austria,Poland,United Kingdom,Portugal,Greece,Spain
Call: Modular multi-powertrain zero-emission systems for HDV (BEV and FCEV) for efficient and economic operation (2ZERO) (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 22401515.43
EU funding (EUR): 16594389.5
Participants: 40
Project status: SIGNED

Heavy-duty vehicles account for about 25% of EU road transport CO2 emissions and about 6% of total EU emissions. In line with the Paris Agreement and Green Deal targets, Regulation (EU) 2019/1242 setting CO2 emission standards for HDVs (from August 14, 2019) forces the transition to a seamless integration of zero-emission vehicles into fleets. In line with the European 2050 goals ESCALATE aims to demonstrate high-efficiency zHDV powertrains (up to 10% increase) for long-haul applications that will provide a range of 800 km without refueling/recharging and cover at least 500 km average daily operation (6+ months) in real conditions. ESCALATE will achieve this by following modularity and scalability approach starting from the β-level of hardware and software innovations and aiming to reach the γ-level in the first sprint and eventually the δ-level at the project end through its 2 sprint-V-cycle. ESCALATE is built on the novel concepts around 3 main innovation areas, which are: i) Standardized well-designed, cost effective modular and scalable multi-powertrain components; ii) Fast Fueling & Grid-friendly charging solutions; and iii) Digital Twin (DT) & AI-based management tools considering capacity, availability, speed, and nature of the charging infrastructures as well as the fleet structures. Throughout the project lifetime, 5 pilots, 5 DTs and 5 case studies on TCO (with the target of 10% reduction), together with their environmental performance via TranSensusLCA will be performed. The ultimate goal is to develop well-designed modular building blocks with a TRL7/8 based on business model innovations used for 3 types of zHDVs {b-HDV,f-HDV,r-HDV}. Furthermore, 3 white papers will be produced, one of which will contribute defining the pathway for reducing well-to-wheel GHG emissions from HDVs based on results and policy assessments.

Keywords: modularity,scalability,ai based fleet management tool,logistic intelligence,battery hdv,fuel cell hdv,range extender hdv
Sensing Aberrant Transcription by MYC Multimers (SENATR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2498471.0
EU funding (EUR): 2498471.0
Participants: 1
Project status: SIGNED

Deregulated expression of MYC or one of its paralogues, MYCN and MYCL, maintains the growth of most human tumors. All current models explain the oncogenic potential of MYC proteins by their ability to form complexes with MAX that universally bind to active promoters and the ability of these complexes to induce a tumor-specific gene expression pattern. While MYC conforms to this model during unperturbed cell growth, we have discovered two paradigmatic situations in which MYC proteins undergo fundamental changes in their biochemical state, association with MAX and localization on chromatin: In response to pharmacological or physical disruption of transcription elongation, MYC moves away from active promoters to form large, spherical multimers that surround stalled replication forks. These multimers contain transcription termination factors and form a zone that shields stalled forks from RNA polymerase. Second, MYCN forms high molecular weight complexes during the S phase of the cell cycle that do not contain MAX and, like MYC multimers, contain termination factors. Their assembly depends on RNA that is normally degraded by the nuclear exosome, arguing that they too form in response to aberrant transcription. The switch between heterodimeric and multimeric states depends on non-proteolytic ubiquitylation of MYC, which alters protein-protein interactions that retain MYC at promoters. Our data show that MYC proteins exist in a hitherto unknown dynamic equilibrium between globally promoter-bound heterodimers and multimers that form locally in response to perturbed transcription. We aim to show that these dynamics enable tumor cells to cope with stress arising from deregulated transcription and are crucial for MYC´s oncogenic function. We expect that inhibiting MYC multimerization will maintain normal growth but block the ability of tumour cells to cope with deregulated transcription and is therefore a valid therapeutic strategy for targeting oncogenic functions of MYC

Keywords: pancreatic carcinoma,neuroblastoma,oncogenes,myc,mycn,pediatric tumors,transcription,dna damage
Inferring patterns of ancestral whole genome duplications (paleopolyploidy) in chelicerates (CheliPloidy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Gabon
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-15
End date: 2028-01-14
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

Whole genome duplication (WGD) is a drastic event that results in the creation of new genetic material and has been suggested to play a major role in evolutionary innovations and adaptation. While ancestral WGDs (paleoploidizations) are common in plants, only a handful examples have been proposed in animals, such as in vertebrates or salmons. Among invertebrates, WGD events have been inferred in chelicerates, an arthropod clade including marine and terrestrial groups – the arachnids. Specifically, a shared event in the common ancestor of spider and scorpions, and up to 3 independent rounds in the marine horseshoe crabs. However, many of these inferences are mostly based on evidence from few loci, such as Hox genes, with a recent study questioning the validity of these conclusions. Therefore, genome-wide investigations with a diverse taxon sampling may help to answer how many paleoploidization events have taken place in chelicerates. The CheliPloidy project will investigate the signals of WGD in chelicerates using newly assembled complete genome encompassing most of their diversity. Importantly, no study has considered that return to diploidy may have happened at different intervals (delayed rediploidization), scenario compatible with the different gene histories seen in the group. We will employ multiple state-of-the-art methods and develop novel ones to look for these signals. For example, we will analyse thousands of gene families trees, assess their synteny, and compare signals of divergence among within-species paralogs (including ohnologs derived from the WGD). As the phylogeny of chelicerates is contentious, we will test the most likely scenarios –alternative backbone trees– to polarize patterns of WGD (how many and which are shared). Altogheter, this project will not only sheds light on the complex genome evolution and the phylogeny of chelicerates, but also demonstrates how a combination of comparative methods can be used to infer signals of ancient WGDs.

Keywords: whole genome duplication,paleoploidy,phylogenomics,molecular clocks,synteny,chelicerates,arachnids
The Inner Galapagos – Molecular Ecology of the Retroviral-piRNA Arms Race (ERVolution)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2498943.0
EU funding (EUR): 2498943.0
Participants: 1
Project status: SIGNED

The ongoing arms race between transposable elements and their host organisms is a central driver of genetic innovation and biological diversity. Yet, despite this crucial role, the underlying principles that govern transposon-host interactions remain poorly understood. The ERVolution project aims to gain critical insights into the evolutionary dynamics and rules of the ancient transposon-host conflict. The project focuses on the Drosophila ovary ecosystem and the diversification of insect endogenous retroviruses (ERVs), a highly successful group of genome parasites that have acquired the ability to invade germ cells from surrounding somatic cells as viral particles to multiply in the germline genome. Through a multidisciplinary approach that combines host and transposon genetics, single-cell genomics, machine learning, and controlled transposon invasion experiments, we will investigate how transposon-host interactions create biological diversity by driving molecular innovations on both sides. Specifically, the project aims to uncover (i) how infectious ERVs exploit cell biological processes in the host gonad for their soma-to-germline transmission, (ii) how ERVs diversify their compact cis-regulatory elements to optimally adapt their expression to the host, and (iii) how the host transposon defence system exploits an Achilles' heel of ERVs, their unusual nucleotide composition, to silence both old and new genome invaders. The ERVolution project provides a unique opportunity to uncover general principles of transposon-host interactions by studying the molecular and evolutionary processes of a major battle between multiple transposons and an experimentally accessible host model organism. The project’s results are expected to have far-reaching implications beyond Drosophila, particularly in the fields of retrovirology, the evolution of cis-regulatory sequences of transposons, and the fundamental question of how eukaryotic cells distinguish their own from foreign RNA.

Keywords: transposon host co evolution endogenous retroviruses piwi pirna pathway drosophila oogenesis cis regulatory sequence evolution ltr retrotransposons pirna biogenesis germline biology
The Present Dead: Investigating Interactions with the Dead in Early Medieval Central and Eastern Europe from 5th to 8th Centuries CE (PresentDead)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria,Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1965598.0
EU funding (EUR): 1965598.0
Participants: 3
Project status: SIGNED

The project aims to investigate the practical, mental and emotional dimensions of human interactions with the materials of the dead (graves, human remains and artefacts) in early medieval central and eastern Europe (5th to 8th centuries CE). Based on archaeological and textual evidence, diverse contexts of contact will be investigated through an innovative approach combining cutting-edge scientific methods, technical solutions and new theoretical approaches. The project’s working hypothesis is that perspectives on interaction with the materials of the dead will vary with the ritual stages of funerals. Early medieval cemeteries comprise of up to hundreds of graves where corpses were generally inhumed in individual graves, frequently together with lavish objects. Many graves were interfered with soon after burial. While disturbed graves have elsewhere been seen as an inferior source of evidence, this project argues that these interventions are important sources for early medieval practices relating to the dead. Investigating cemeteries and out-of-cemetery contexts in four central- and eastern European regions it pursues the following objectives: 1. Investigating the range of practices and contexts in the archaeological records. 2. Analysing textual perspectives in diverse genres. 3. Synthesising material and textual perspectives via an innovative technical solution for semantic integration of data. The methodological objectives for achieving the archaeological goals are: 1. Consolidation of methods and development of research protocols. 2. Development of strategies to mitigate deficiencies of archaeological data. The development of digital tools, moving from high- to low resolution evidence, will be novel and key to the approach. The project will significantly contribute to our understanding of the relationship between the living and the dead in early medieval Europe.

Keywords: mortuary archaeology,taphonomy,early medieval period,digital humanities,
Towards Future Interfaces With Tuneable Adhesion By Dynamic Excitation (SURFACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1499750.0
Participants: 1
Project status: SIGNED

Macroscopic adhesion is of utmost importance in key technologies such as soft and climbing robots, aerospace grasping technologies, human-robot interactions, pick-and-place manipulators. Commonly, bioinspired adhesives interfaces have been characterized from a quasi-static perspective, neglecting the effect of dynamic excitations. Nevertheless, recent observations suggest that added micro-vibrations may be exploited to strongly enhance and rapidly tune macroscopic adhesion. By exploiting the multiplicative coupling between geometric- and viscoelastic vibration-induced enhancements of macroscopic adhesion, SURFACE aims at designing future soft interfaces with unprecedented and tuneable adhesion strength. To this end, I aim to: (i) develop highly efficient numerical tools for studying adhesion of patterned soft surfaces under micro-vibration excitation, (ii) unveil the coupling effect between topography and viscoelasticity that determine the interfacial strength and toughness (iii) design optimal surface topography and excitation for macroscopic adhesion tuning, by exploiting artificial intelligence models to unveil new mechanisms for adhesion enhancement, (iv) prove the adhesive performance reached, by experimentally testing high-resolution 3D printed interfaces with the desired topography and superposed micro-vibrations. So far, the adhesive performance of bioinspired patterned interfaces has been limited by manufacturing capabilities at the micro/nanoscale. SURFACE ground-breaking approach aims at exploiting dynamics excitation to outperform state-of-the-art adhesive interfaces. By exploiting artificial intelligence models, SURFACE aims at revealing new mechanisms for adhesion enhancement, which lay beyond our intuition. Rapidly tuneable strong adhesive interfaces have the potential to revolutionize cutting-edge technologies based on soft adhesive interfaces that require to move and place objects quickly and with accuracy.

Keywords: surface adhesion patterned surfaces dynamic excitation
Chirality and spin selectivity in electron transfer processes: from quantum detection to quantum enabled technologies (CASTLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Italy,United States,Germany,Israel
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-01-01
End date: 2028-12-31
Duration (months): 72.0
Total project cost (EUR): 8976957.0
EU funding (EUR): 8976957.0
Participants: 7
Project status: SIGNED

Chirality is a key property of molecules important in many chemical and nearly all biological processes. Recent observations have shown that electron transport through chiral molecules attached to solid electrodes can induce high spin polarization even at room temperature. Electrons with their spin aligned parallel or antiparallel to the electron transfer displacement vector are preferentially transmitted depending on the chirality of the molecular system resulting in Chirality-Induced Spin Selectivity (CISS). The long-term vision of the CASTLE project is to transform the CISS effect into an enabling technology for quantum applications. This will be accomplished by achieving four key objectives. 1) The occurrence of CISS will be studied at the intramolecular level by photo-inducing rapid electron transfer within covalent donor-chiral spacer-acceptor molecules to generate long-lived radical pairs (RPs). 2) Direct detection of RP spin polarization will be performed using time-resolved and pulsed electron and nuclear magnetic resonance techniques. In addition, polarization transfer from one of the radicals comprising the spin-polarized RP to a stable molecular spin (Q) will be used to initialize the quantum state of Q, making it a good qubit for quantum applications, particularly sensing. 3) Quantum mechanical studies of the CISS effect will provide predictive models for molecular qubit design. 4) The CISS effect will be used to control, readout, and transfer information in prototypical devices embedding hybrid interfaces based on semiconducting or conducting substrates, thus dramatically advancing the use of molecular spins in quantum information technologies targeting high-temperature operation. These devices will be used also to prove molecule-based Quantum Error Correction. The knowledge acquired with CASTLE will impact a wide range of fields, including magnetless spintronics, dynamic nuclear polarization for NMR signal enhancement, catalysis, and light harvesting.

Keywords: chirality,electron transfer,molecular magnetism,spin selectivity,spintronics,supramolecular chemistry,coordination chemistry