Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel Oligonucleotide-based Strategies for Efficient Telomerase Inhibition (NOSETI2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Within the last years, the ribonucleoprotein telomerase has emerged as an attractive, yet elusive, drug target for the treatment of cancer and several age-related diseases. This is because it has been estimated that telomerase is abnormally up-regulated in around 90% of human tumors. However, despite the current efforts to exploit the therapeutic potential of telomerase, there is still a need for the development of alternative chemical strategies that may unravel novel options for efficient therapeutic intervention, especially at a time when our understanding of many aspects of telomerase biology is ever increasing. The proposed research aims at the use of new molecular strategies for the discovery of efficient telomerase inhibitors based on oligonucleotide conjugates. The project will be based on an interfaced, multidisciplinary approach characteristic of the field of Chemical Biology. It will entail a combination of different techniques, including organic synthesis, coordination and nucleoside chemistry, spectroscopy, biochemistry, and molecular and cellular biology.

Keywords: oligonucleotides,telomeres & telomerase,cancer,platinum complexes,dna alkylating reagents,chemical biology
Grid-Enabled Platform for Simulations in Paediatric Cardiology – Toward the Personalized Virtual Child Heart (SIM-E-CHILD)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Towards sustainable and personalised healthcare
Action type: Collaborative project
Countries involved: Germany,Italy,France,United States,Romania
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-06-30
Duration (months): 30.0
Total project cost (EUR): 1786567.0
EU funding (EUR): 956008.0
Participants: 10
Project status: CLOSED

There is a high demand for patient specific cardiovascular disease therapeutics. Paediatric cardiology, in particular, faces difficult challenges due to the evolving nature of a child’s heart and vascular system. Comprehensive and accurate computer models reconstructed from patient specific data and simulated physical constraints are needed to help determine better and more reliably risk stratification to improve and personalized therapies, and ultimately to decrease morbidity and increase survival of patients. The Sim-e-Child project proposes to develop a grid-enabled platform for large scale simulations in paediatric cardiology, providing a collaborative environment for constructing and validating multi-scale and personalized models of a growing heart and vessels. The project will establish an international cooperation, by linking the EC funded Health-e-Child project with leading institutions such as the American College of Cardiology, Johns Hopkins University, Technical University of Munich, and Siemens Corporate Research. Sim-e-Child is an extension of the Health-e-Child platform that: •Interconnects the Health-e-Child database with new data from two prospective US multicenter studies •Enhances and expands the Health-e-Child heart with existing models of the aorta, aortic valve and mitral valve, and with computational fluid dynamics •Integrates the Health-e-Child Gateway and Case Reasoner with versatile tools for simulation workflow composition (iKDD) and sharing of scientific experiments (SciPort) The objective of the Sim-e-Child is to strengthen the impact of the Health-e-Child project by creating an international simulation and validation environment for paediatric cardiology, supported by integrated data repositories. The project will advance the state-of-the-art by providing comprehensive and patient specific models for the dynamic and longitudinal interactions occurring in the left heart, with a focus on the congenital aortic arch disease and repair.

Keywords: grid,large-scale simulation,personalized disease models,cardiology
Methods for predictAble Design of heterogeNeous Embedded System with adaptivity and reliability Support (MADNESS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Italy,Switzerland,Germany,Netherlands,Netherlands,Netherlands,Germany
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 39.0
Total project cost (EUR): 2895346.0
EU funding (EUR): 1950000.0
Participants: 9
Project status: CLOSED

The MADNESS project aims at the definition of innovative system-level design methodologies for embedded systems, able to drive the optimal composition of an heterogeneous MPSoC architecture, according to the requirements and the features of a given target application field. The proposed methodologies will extend the classic concept of design space exploration, to cope with high heterogeneity, technology scaling, system reliability and multi-application demands, pursuing the following objectives: -Improve design predictability of highly heterogeneous embedded systems, bridging the so called “implementation gap”, i.e. the gap between the results that can be predicted during the system-level design phase and those eventually obtained after the on-silicon implementation. -Consider, apart from more traditional constraints (typically, cost, performance, power consumption), continued availability of service, taking into account fault recovery as one of the optimization factors to be satisfied. -Support adaptive runtime management of the architecture. The technical approach of the project will rely on the following methods: -In order to improve the design predictability, traditional system-level design methodologies will be extended to consider variables strictly related with physical implementation of the architecture, leveraging a specific layer for rapid and accurate on-hardware FPGA-based emulation. -In order to address fault tolerance and adaptive runtime resources management, new methodologies are going to be defined and included in system-level exploration. Specific hardware/middleware IP modules will be developed to pursue those objectives. The results of the project are expected to have a deep impact on the design flow for high-complexity embedded systems, facilitating and enhancing the exploration of the architectural design space, therefore resulting in a significantly increased overall productivity.

Keywords: system-level design,design space exploration,technology awarness,heterogeneity,fault tolerance,adaptivity
Socially Aware, collaboRative, scAlable Coding mEdia distributioN (SARACEN)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Spain,Greece,Portugal,Cyprus,Türkiye,United Kingdom,Poland
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2013-03-31
Duration (months): 39.0
Total project cost (EUR): 4464201.0
EU funding (EUR): 3075980.0
Participants: 10
Project status: CLOSED

The rapid progress in hardware/software media technologies has changed the role of individuals from passive content consumers to active content creator/producers. It is clear that in a few years everyone will be multimedia content producer (by publishing digital pictures, video recordings, remote e-health services, home surveillance, etc.), multimedia content mediator (by storing/forwarding streaming content) and multimedia content consumer (digital television, video on demand, mobile broadcasting and alike).Within such environment, collaborative, social /context aware and scalable media distribution is required for a) maintaining the integrity and quality of delivered multimedia content, b) optimizing the quality of experience in a way of delivering truly personalized high Quality of Experience (QoE) media streaming services, c) adapting and enriching the quality of media across the whole distribution chain.

Keywords: media
Performance Portability and Programmability for Heterogeneous Many-core Architectures (PEPPHER)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Austria,Sweden,France,Germany,Sweden,Germany,United Kingdom,Ireland
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 3436078.0
EU funding (EUR): 2553615.0
Participants: 9
Project status: CLOSED

The emergence of highly parallel, heterogeneous, often incompatible and highly diverse, many-core processors poses major challenges to the European software-intensive industry. It is imperative that such architectures can be fully exploited without starting from scratch with each new design. In particular, there is an urgent need for techniques for efficient, productive and portable programming of heterogeneous many-cores. PEPPHER will provide a unified framework for programming architecturally diverse, heterogeneous many-core processors to ensure performance portability. PEPPHER will advance state-of-the-art in its five technical work areas: (1) Methods and tools for component based software; (2) Portable compilation techniques; (3) Data structures and adaptive, autotuned algorithms; (4) Efficient, flexible run-time systems; and (5) Hardware support for autotuning, synchronization and scheduling. PEPPHER is unique in proposing direct compilation to the target architectures. Portability is supported by powerful composition methods and a toolbox of adaptive algorithms. Heterogeneity is further managed by efficient run-time schedulers. The PEPPHER framework will thus ensure that applications execute with maximum efficiency on each supported platform. PEPPHER is driven by challenging benchmarks from the industrial partners. Results will be widely disseminated through high-quality publications, workshops and summer-schools, and an edited volume of major results. Techniques and software prototypes will be exploited by the industrial partners. A project website (www.peppher.eu) gives continuity to the dissemination effort. The PEPPHER consortium unites Europe’s leading experts and consists of world-class research centres and universities (INRIA, Chalmers, LIU, KIT, TUW, UNIVIE), a major company (Intel) and European multi-core SMEs (Codeplay and Movidius), and has the required expertise to accomplish the ambitious but realistic goals of PEPPHER.

Keywords: programmability,performance portability,many-core systems,heterogeneous multi-core systems
Bridging Research in Ageing and ICT Development (BRAID)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for Independent Living, Inclusion and Governance
Action type: Coordination and support actions
Countries involved: United Kingdom,Australia,Portugal,Netherlands,Ireland,Germany,Italy,United Kingdom
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-03-01
End date: 2012-06-30
Duration (months): 28.0
Total project cost (EUR): 1200411.0
EU funding (EUR): 999287.0
Participants: 9
Project status: CLOSED

Bridging Research in Ageing and ICT Development (BRAID) will develop a comprehensive RTD roadmap for active ageing by consolidating existing roadmaps and by describing and launching a stakeholder co-ordination and consultation mechanism. It will characterise key research challenges and produce a vision for a comprehensive approach in supporting the well-being and socio-economic integration of increasing numbers of senior citizens in Europe. BRAID responds to the apparent need to consolidate the various existing perspectives, plans, roadmaps and research and to coordinate effectively the stakeholders in ICT and Ageing. It will utilise knowledge repositories and stakeholder networks to create a self-sustaining, dynamic strategic mechanism for overcoming the fragmentation that has plagued e-inclusion and for improving co-ordination and collaboration among stakeholders. BRAID has three main objectives, to: • Create a dynamic ICT and Ageing roadmap that addresses older people&apos;s needs not otherwise well met, that identifies and benefits from best practices in the EU and elsewhere and that analyses current and potential gaps in knowledge and execution; • Instantiate a strategic research agenda that tracks and builds upon existing, emerging and disruptive technologies and that responds to the changing socio-economic conditions of stakeholders; • Expand the BRAID networks of contacts to build a self-sustaining co-ordination mechanism which is viral and ubiquitous and reaches out across the heterogeneity of stakeholders. BRAID will build upon the experience and knowledge developed in previous projects while taking account of e-inclusion efforts in the EU27 as well as Australia, Canada, Japan and the US. The team is a unique group made up by representatives of the four FP7 ICT and Ageing roadmap consortia (AALIANCE, CAPSIL, ePAL, SENIOR) and gathers together EU excellence in the field of ICT and Ageing from the main, relevant perspectives.

Keywords: stakeholder co-ordination mechanism,roadmap,e-inclusion,vision,scenarios,workshops,independent living,ageing
Roles of Pitx, Dach and Meox genes in adult skeletal muscle stem cells (SATELLITE CELL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Stem cells are present in many adult tissues in a quiescent state. Their contribution to tissue repair depends on their activation, leading to proliferation and subsequent differentiation or return to quiescence. Skeletal muscle provides a model in which to study adult stem cell behavior. This tissue regenerates after injury and the muscle satellite cell is key to this process. These quiescent cells, located under the basal lamina of muscle fibres become activated upon injury, proliferate and differentiate into new muscle fibres or revert to quiescence. Examining the different states that a satellite cell can adopt under physiological conditions should lead to the identification of new regulators of myogenesis, and contribute to a better understanding of the mechanisms controlling quiescence and activation. Transcriptome analysis were performed on purified satellite cells isolated from adult muscles where these cells are quiescent and from growing or regenerating muscles, where they are activated. This analysis provided new insights into the genes differentially expressed in both states. My project will be to follow up on this work by focusing on three genes, Dach1, Meox2 and Pitx2/3. Those genes encode transcription factors whose profiles suggest they are involved in the function of muscle adult stem cells. Proliferation and differentiation of satellite cells will be studied in vivo in regenerating muscles of Pitx2/3 conditional mutant mice, or after inhibition of Dach1 and Meox2 expression by RNAi viral infection of injured muscle. Similarly, ex vivo proliferation and differentiation of satellite cells in single fibers and primary cultures will be analyzed after Dach1 or Meox2 knock-down by RNAi. Conversely, the consequences of the over-expression of these genes will be investigated in single fiber preparations and cultured satellite cells. These experiments are expected to give insights into the role of these genes in the physiology of satellite cells.

Keywords: cell biology,molecular genetics,laboratory animal science,molecular biology,skeletal muscle satellite cells,transcription factor,quiescence,proliferation,differentiation,regeneration
UpgradiNg ICT excellence by strengthening cooperation between research Teams in an enlarged Europe (UNITE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Horizontal support actions
Action type: Coordination and support actions
Countries involved: Portugal,Belgium,Bulgaria,Slovenia,Romania
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-02-01
End date: 2013-04-30
Duration (months): 39.0
Total project cost (EUR): 560561.0
EU funding (EUR): 495995.0
Participants: 5
Project status: CLOSED

UNITE develops a set of activities to reinforce the cooperation between research teams and improve the level of excellence of ICT research across an Enlarged Europe, in the federated theme of “Future of the Internet”. The project takes benefit from the large experience of the consortium in research oriented collaborative activities, and uses the collaborative platform of I-VLab to support its activities. Secondment is the priority for UNITE, taking most of the project budget. Moreover, UNITE will not develop its secondment activities from scratch, as relevant preparatory work with effective results was already done during the project proposal preparation. UNITE consortium sent out in advance a call to organizations around the Enlarged Europe, and got 121 written interests to participate in the UNITE secondment activities, i.e., UNITE has at project starting time a committed offer/demand matrix that identifies organizations interests and contact responsibles within the UNITE secondment. Thus, UNITE proposes to start the secondment activities as soon as the project begins, based on the pre-elaborated secondment matrix involving now already more than 120 institutions across the enlarged Europe, and containing 863 send and 1000 receive requests. To save project budget, and increase the number secondment activities, whenever possible the ERASMUS programme will be considered. UNITE organizes open 2 doctoral symposiums that provide the opportunity to enlarge the community in collaboration with both the sending and receiving institutions. A restrict management will be put in place, to control the costs in a correct timing and progress control of each work package; and regulate and manage the Secondment activities. For ensuring a long–term cooperation and the pursuit of the secondment actions, UNITE creates an “Eastern Europe” INTEROP-VLab Pole, enabling to build up consortiums to widen the participation of enlarged Europe in EC ICT research projects.

Keywords: secondment,mobility,synergies,networking,knowledge sharing
The Hand Embodied (THE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Cognitive systems, interaction, robotics
Action type: Collaborative project
Countries involved: Italy,Germany,Greece,Netherlands,France,Germany,Sweden,Sweden,Germany,Netherlands
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-03-01
End date: 2014-05-31
Duration (months): 51.0
Total project cost (EUR): 9576461.0
EU funding (EUR): 7175692.0
Participants: 11
Project status: CLOSED

The scientific goals of the proposal revolve around the reciprocal linkages between the physical hand and its high-level control functions, and about the way that the embodiment enables and determines its behaviours and cognitive functions. THE Hand Embodied refers to the hand as both a cognitive entity standing for the sense of active touch and as the physical embodiment of such sense, the organ, comprised of actuators and sensors that ultimately realize the link between perception and action. The study of the intrinsic relationship between the hand as a cognitive abstraction and its bodily instance will be made possible by: (a) performing neuroscientific and perceptual behavioural studies with participants engaged in controlled manual activities; and (b) the parallel development of a theoretical framework to lay the foundations for design and control of robotic hands and haptic interfaces. The general idea is to study how the embodied characteristics of the human hand and its sensors, the sensorimotor transformations, and the very constraints they impose, affect and determine the learning and control strategies we use for such fundamental cognitive functions as exploring, grasping and manipulating. The ultimate goal of the present proposal is to learn from human data and hypotheses-driven simulations how to devise improved system architectures for the hand as a cognitive organ, and eventually how to better design and control robot hands and haptic interfaces. The project hinges about the conceptual structure and the geometry of such enabling constraints, or synergies: correlations in redundant hand mobility (motor synergies), correlations in redundant cutaneous and kinaesthetic receptors readings (multi-cue integration), and overall sensorimotor system synergies. These are also our key ideas for advancing the state of the art in artificial systems for robotic manipulation and haptic and neuroprosthetic interfaces.

Keywords: manipulation,theory of synergies,robot hands,haptic interfaces
Diagnosis, Error Modelling and Correction for Reliable Systems Design (DIAMOND)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Estonia,Sweden,Germany,Austria,Sweden,Israel,United Kingdom
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 3863697.0
EU funding (EUR): 2893000.0
Participants: 8
Project status: CLOSED

Increasing design costs are the main challenge facing the semiconductor community. Assuring the correctness of the design contributes to the major part of the problem. However, while diagnosis and correction of errors are more time-consuming compared to error detection, they have received far less attention, both, in terms of research works and industrial tools introduced. Another, orthogonal threat to the development is the rapidly growing rate of soft-errors in the emerging nanometer technologies. According to roadmaps, soft-errors in sequential logic are becoming a more severe issue than in memories. However, the design community is not ready for this challenge because existing soft-error escape identification methods for sequential logic are inadequate. The DIAMOND project addresses the above-mentioned challenges. The aim of DIAMOND is improving the productivity and reliability of semiconductor and electronic system design in Europe by providing a systematic methodology and an integrated environment for the diagnosis and correction of errors. DIAMOND will develop: - A unified, holistic diagnostic model for design and soft errors; - Automated localisation and correction techniques based on the unified model, both pre-silicon and post-silicon; - Implementation of a reasoning framework for localisation and correction, encompassing word-level techniques, formal, semi-formal, and dynamic techniques; - Integration of automated correction with the diagnosis methods. DIAMOND reaches beyond the state-of-the-art by proposing an integrated approach to localisation and correction of specification, implementation, and soft errors. In addition, it considers faults on all abstraction levels, from specification through implementation down to the silicon layout. Handling this full chain of levels allows DIAMOND take advantage of hierarchical diagnosis and correction capabilities incorporating a wide range of error sources.

Keywords: design errors,soft errors,localisation,correction,reliable systems,semiconductors,repair,post-silicon debug,in-situ test,fault diagnosis,diagnostic modelling,reasoning engines