Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fluctuations in continuum and conservative stochastic partial differential equations (FluCo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1999864.0
EU funding (EUR): 1999864.0
Participants: 2
Project status: SIGNED

Fluctuations are ubiquitous in real world contexts and in key technological challenges, ranging from thermal fluctuations in physical systems, to algorithmic stochasticity in machine learning, to fluctuations caused by small-scale weather patterns in climate dynamics. At the same time, such complex systems are subject to an abundance of influences, and depend on a large variety of parameters and interactions. A systematic understanding of the interplay of stochasticity and complex dynamical behavior aims at unveiling universal properties, irrespectively of the many details of the concrete systems at hand. Its development relies on the derivation and analysis of universal concepts for their scaling limits, capturing not only their average behavior, but also their fluctuations. We propose to analyze the class of conservative stochastic partial differential equations (SPDE) as such a universal fluctuating continuum model, and unveil its mathematical analysis as a fruitful field for the discovery of new mathematical structures and methods. The key challenges targeted in this proposal are: (1) Well-posedness of singular conservative SPDEs (2) Singular limits for supercritical conservative SPDEs (3) Stochastic dynamics for conservative SPDEs. We aim to approach these challenges by a novel combination of recent scientific breakthroughs in the fields of strongly nonlinear, conservative SPDEs and singular SPDEs. We thereby intend to advance the highly active and productive field of (singular) SPDEs, which has inspired striking mathematical progress in the last decade. The analysis of conservative SPDEs conjoins several contemporary fields of analysis and probability: Singular SPDEs, nonlinear PDEs, kinetic theory, supercriticality, and stochastic dynamical systems. We are, therefore, confronted with an interplay of stochasticity, irregularity, and nonlinearity, posing new challenges and going far beyond established methods.

Keywords: singular stochastic partial differential equations,stochastic conservation laws,degenerate partial differential equations,kinetic solutions,renormalized entropy solutions,random dynamical systems,stochastic dynamics
Public Lyric: Poet-Scholars in the Public Sphere (Public Lyric)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Public Lyric makes a conceptually bold, publicly engaged case for the role of contemporary women poet-scholars in an emerging new model of the public humanities. Public Lyric shows how contemporary poet-scholars in the Anglophone and European academy perform a vital new form of public thinking that navigates aslant the predominant conceptual model of the public humanities. Among the pioneers of this emergent model are high-profile women scholars whose poetic and hybrid-poetic compositions, with all the theoretical heft and nuance of their academic writing, place the actions of speaking, addressing, and giving testimony at the heart of a transformative public discourse.

Keywords: contemporary poetry,lyric,public humanities
A single-cell atlas of human soft tissue sarcoma ecosystems with focus on mechanisms of immune evasion (CASSIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Soft tissue sarcomas (STS) are rare, aggressive cancers. About 50% of patients with high-risk STS die within 5 years after diagnosis, highlighting the need for novel treatment approaches. A major obstacle for novel treatment design is our limited understanding of STS as ecosystems, shaped by diverse tumor cells and their interactions with cells of the microenvironment. Emerging strategies that target cellular relationships in STS are promising, such as immune checkpoint inhibition. First clinical trials assessing immune checkpoint inhibition were promising, but success varied greatly among different STS subtypes and a rational selection of patients was not available. A comprehensive description of the complex cellular diversity and interactions in STS tumor ecosystems and links to disease progression are currently missing. Here we will combine simultaneous detection of single-cell transcriptomes and cell surface proteins with 32-plex immunofluorescence imaging to characterize STS tumor and immune cell diversity with single-cell spatial resolution in seven STS subtypes. The STS subtypes include dedifferentiated liposarcoma, Ewing sarcoma, myxoid/round cell liposarcoma, clear cell sarcoma, desmoplastic small round cell tumor, fibromyxoid sarcoma, and solitary fibrous tumor, present with poor prognosis and are promising candidates for immunotherapies. Objectives are (1) to characterize the cellular diversity and tumor-immune interactions in STS ecosystems using simultaneous single-cell transcriptomics and cell surface proteomics, (2) to profile the STS immunoenvironment with single-cell spatial resolution in situ, and (3) to functionally assess candidate tumor-immune interactions in vitro. This project will provide the first single-cell atlas for seven STS subtypes and will enable a better understanding of STS tumor ecosystems, pave the way for novel precision oncology approaches, and facilitate the identification of candidates for immunotherapy clinical trials.

Keywords: sarcoma cancer,tumor ecosystem,immune profiling,tumor immune interactions,single cell transcriptomics and cell surface proteins,multiplexed immunofluorescence imaging,rare cancer
Live Cell Spectroscopy Analysis for Personalised Particle Radiation Therapy of Metastatic Bone Cancer (BoneOscopy)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Spain,Portugal,Slovenia,Switzerland
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 3069321.25
EU funding (EUR): 3069321.25
Participants: 6
Project status: SIGNED

Metastatic bone cancer is an incurable disease and one of the most complex cancers to treat. Due to the high dose, tumour imaging is currently performed at the beginning and end of standard particle radio-therapy (PRT), making personalised treatment difficult. The main goal of BoneOscopy is to develop a radically new technology to enable informed medical decisions by monitoring bone cancer on a daily basis during PRT. At the heart of BoneOscopy is the ability to detect prompt gamma (PGs) emitted by cancer during PRT and separate them from healthy tissue, unlocking the full potential of spectroscopic analysis without the need for additional dose. The development of a highly specialised detection and collimation system will enable accurate spectroscopic analysis of a very small volume or region within the cancer. As the number of PRT centres grows, we anticipate that within 10 years BoneOscopy will benefit all patients treated with proton and carbon ions. The objectives of BoneOscopy will be achieved by its interdisciplinary consortium, which brings together six partners from five European countries with key expertise in bioengineering and PRT (DKFZ), medical physics and engineering (CSIC), fast electronics for PRT (LIP), Monte Carlo simulations and clinical PRT experience (THM), turnkey software for high performance medical devices (Cosylab) and EU project management, communication and dissemination (accelCH). If achieved, the proposed science-to-technology breakthrough will have a transformative impact on current cancer treatment by providing a safe, personalised and quantitative measure of daily treatment efficacy, thereby contributing to the global fight against cancer. In summary, BoneOscopy will lead to a significant reduction in the health burden in Europe and worldwide, improved quality of life for patients, reduced costs for healthcare systems and improved sustainability of healthcare.

Keywords: metastatic bone cancer,particle radiation therapy,spectroscopic bone analysis,biomedical engineering
Virus-Inspired modular Assembly for cargo loading in Extracellular Vesicles-Inspired CArdiac REpair (VIA-EVICARE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The fundamental objective of the VIA-EVICARE ERC Proof of Concept project is to ascertain the technical and commercial feasibility of a ground-breaking technology to revolutionize the delivery of therapeutics via extracellular vesicles (EVs). EVs are naturally occurring nanosized vesicles that facilitate the transfer of biological cargo between cells and offer numerous benefits over conventional drug delivery systems. By leveraging a novel, virus-inspired mechanism, we aim for a modular design that combines a significant improvement of targeting, loading, and release of therapeutics that overcomes the limitations of existing strategies. By designing and synthesizing self-assembling viral proteins and recruiting EV biogenesis components, we aim to: I. Validating the efficiency and specificity of EV-therapeutic loading, EV-generation, and EV uptake mechanisms upon introduction of different self-assembling proteins. II. Optimizing the modular design for large-scale production, ensuring reproducibility and cost-effectiveness and validate our innovative VIA-EVICARE loading strategy by assessing biodistribution and functional delivery in vivo. III. Conduct a comprehensive intellectual property (IP) landscape analysis to establish freedom-to-operate (FTO) and ensure that our technology can be commercialized without infringing on existing patents. IV. Develop a robust and detailed business plan to effectively guide the commercialization of our loading technology, thus bringing a transformative solution to treating various diseases.
The function of iron homeostasis in plant stress responses (PlantsStressIron)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Human nutrition depends on plant growth. However, climate change, pollution and intense agricultural practices cause soil degradation imposing severe stresses for crops, threatening food security. As sessile organisms, plants evolved complex molecular and physiological mechanisms to adapt to these abiotic stresses. In recent years, it has been unveiled that iron (Fe) oxidation state dynamics is a key factor for optimal response to several abiotic stresses. This proposed regulatory role for Fe is disruptive and largely unexplored. Thus, deciphering the molecular mechanisms at the intersection of Fe homeostasis and stress responses has important implications for agriculture and our understanding of plant resilience. This is in line with the second goal of the United Nations 2030 Agenda for Sustainable Development, which aims to transform our world by ending hunger, achieving food security, improving nutrition and promoting sustainable agriculture. The present project aims to contribute to our understanding of plant resilience by studying the regulatory role of Fe under nutritional stresses commonly present in soils.

Keywords: cybdom proteins,plant molecular genetics,evolution,stress,signalling
Exploring natural selection due to the Black Death and continuous human population genetic structure (EPIDEMIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1495000.0
EU funding (EUR): 1495000.0
Participants: 1
Project status: SIGNED

The study of ancient human DNA has been revolutionary in identifying large-scale admixtures and genetic variants subject to natural selection. Yet, key knowledge gaps persist. First, ongoing genetic mixing within spatially continuous populations is poorly understood. Second, the underlying selective pressures, particularly of infectious diseases, remain debated. To bridge both gaps, I propose sequencing 500 victims of the Black Death, one of the deadliest pandemics in human history, from a site in Central Europe and using this data synergistically with novel computational tools to make two breakthroughs. My first objective is to pioneer linking a large number of ancient and modern genomes through shared long haplotypes (known as IBD segments). IBD-sharing with modern genomes across Europe will reveal, for the first time, how genetic ancestry spread across space, starting from a large sample of a singular position and time. New inference tools using IBD-sharing will offer unprecedented insights into the European population structure of recent centuries, including mobility and effective population densities, and address a critical lack of population genetic models for spatially continuous populations. The second objective is to pinpoint genetic variants relevant to Black Death mortality. Observing the removal of alleles, for the first time in molecularly confirmed plague mass graves, will directly link an infectious disease and the resulting natural selection. The findings will decisively resolve long-standing debates regarding the human selective impact of the Black Death. Both IBD-sharing with modern Europeans and selection screens will greatly benefit from the large sample size of Medieval genomes. The synergy between the new analysis and tools I propose will break new ground for two key topics in population genetics relevant beyond humans, inferring the structure of continuous populations and the impact of natural selection.

Keywords: ancient dna,identity by descent ibd segments,demographic inference,natural selection,recent human evolution
Electrical tomography for phase change monitoring (ET4PCM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-09
End date: 2025-07-08
Duration (months): 30.0
Total project cost (EUR): 215937.6
EU funding (EUR): 215937.6
Participants: 3
Project status: CLOSED

Heating/cooling demands represent more than half of energy consumption in households and drive most of energy-related GHG emissions in the residential sector. To achieve decarbonisation goals heating/cooling demands must be supplied with heat pumps driven by renewable electricity. However, the mismatch between energy availability and heating/cooling demand needs to be reconciled with low-cost, efficient and flexible energy storage. Latent thermal energy storage (LTES) with phase change materials (PCMs) is becoming a key enabling technology for low-carbon heating/cooling. However, smart control of LTES systems require monitoring of the liquid fraction, which determines the total stored energy. The present research proposal, ET4PCM, aims to develop a first-of-a-kind, smart, non-invasive, versatile impedance sensor to evaluate in real-time the liquid fraction evolution of PCMs in LTES. The ET4PCM sensor will provide detailed information regarding phase distribution evolution during freezing/melting of PCMs in macrocapsules (spherical or cylindrical shells). The project planning contemplates four key tasks, which correspond to the sub-objectives: SO1) Characterization and enhancement of electrical properties of PCMs, SO2) design of the electrical sensing system, SO3) experimental implementation and validation of the proposed sensing system, and SO4) Validation of ET4PCM technology in a real LTES. The research approach involves experimental, numerical, and theoretical research activities. I, Dr. Carolina Mira-Hernández will develop the ET4PCM project under the supervision of Pr. Simone Mancin at University of Padua (UNIPD), who is renowned expert in LTES. In addition, I will spend 3 months during a secondment at the start-up COWA, where I will deploy the ET4PCM sensor in a real-world LTES, and I will have a non-academic placement at HEXXCELL, a consulting company on predictive analytics, where I will develop “in silico” smart control tools for LTES.

Keywords: latent thermal energy storage,liquid fraction,phase change materials,nanotechnology,electrical tomography,thermal energy systems
Highly Ethanol-Selective Electrocatalytic CO2 Reduction Enabled by Site-Specific Heteroatoms Doped Single Atom Catalysts Supported Cu Clusters (SAC-Cu-CO2RR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Electrochemical CO2 reduction reaction (CO2 RR) driven by renewable power is a promising way to convert CO2 to fuels and chemicals, which has been proposed as a sustainable process for the artificial carbon cycle. Among all products, ethanol (C2H5OH) has received extensive attention because it can be directly used as fuel in internal combustion engines and industrial power generation. Cu-based catalysts can efficiently promote C-C coupling toward C2+ products in CO2 RR. However, most Cu-based catalysts still show an insufficient selectivity for C2H5OH (<50 %) due to unfavorable adsorption of several oxygen-containing key intermediates, which cannot achieve its commercial value. As a frontier in materials science, single-atom motifs anchored on N-doped C support (carbon-based SACs), are widely investigated due to their maximum atom-utilization efficiency and highly metal dispersion. Especially, in the field of eCO2 RR, compared to the pure N-C, SACs exhibit an excellent CO selectivity because of the easily optimized coordination environment along with a reconstructed structure. Therefore, combining SACs with Cu-based catalysts in the proper configuration can increase the local CO concentration near Cu-based materials at a low overpotential where Cu alone would be incapable of doing the CO2-to-CO conversion. Meanwhile, the moderate electron-donating ability of SACs will further stabilize the oxygenic C2 intermediate to make the hydrogenation pathway toward C2H5OH production more favorable. As a result, the objective of this project is to design a carbon-based SACs supported Cu clusters architecture by a chemical in-situ growth process to let it serve as a high-efficient catalyst for achieving a high C2H5OH selectivity (> 75 %) at a low overpotential (< 800 mV). This project will set the scene for the fabrication of highly efficient and commercially available electrodes for the eCO2 RR to production of C2H5OH.

Keywords: single atom catalysts,cu based materials,co2 reduction reaction,electrocatalysis,energy conversion