Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Shaping up for mitosis: the origins and consequences of the 3D structure of mitotic centromeres (CENTROSHAPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The centre of the iconic X-shape of human chromosomes is the centromere. It is an extensive locus of specialised chromatin that assembles the kinetochore machinery to connect chromosomes to spindle microtubules for their correct segregation during cell division. How these centromeres obtain three-dimensional (3D) structures that coordinate assembly of kinetochores and resist substantial microtubule-based pulling forces is unknown. We discovered that vertebrate chromosomes are naturally dicentric: their centromeres are two-domain (‘bipartite’) structures, irrespective of underlying DNA sequence or position along the chromosome. Bipartite centromeres assemble bipartite kinetochores that connect to double microtubule bundles, fundamentally altering our view on chromosome-spindle interactions. Chromosome segregation errors in cancer are marked by split centromeres, linking centromere structural integrity to chromosomal instability. Our findings raise many elementary questions about the molecular origins, the 3D structure and the functional consequences of a bipartite mitotic centromere. In CENTROSHAPE, we will integrate advanced imaging and sequencing technologies with state-of-the-art cell models of neocentromeres, inducible centromeres and cancer, to uncover: - How centromere bipartition originates and is maintained, - What 3D chromatin structure shapes the bipartite centromere, and - How destabilisation of bipartite centromeres predisposes to chromosomal instability and centromere damage. The results of CENTROSHAPE will illuminate a hitherto ‘dark’ region of vertebrate mitotic chromosomes – the 3D organisation of centromeres. They will inform on the mechanisms that create this highly specialised chromatin domain in dividing cells and contribute to our understanding of the origins of chromosomal copy number alterations in diseases such as cancer.

Keywords: centromere,mitosis,aneuploidy,genome architecture,chromatin
The Orbem Genus: AI-powered imaging technology for fast, accurate, and contactless object classification & analytics (Orbem Genus)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 3513751.25
EU funding (EUR): 2450876.0
Participants: 1
Project status: CLOSED

Poultry is humanity's most important source of animal protein. Yet, it is extremely difficult to optimize the eggs in - chicks out process, resulting in the waste of billions of eggs, incubation hours, and lives of male chicks. At Orbem we are developing the Genus: AI-powered imaging technology that enables poultry companies to solve their toughest challenges. We use MRI to collect data from inside eggs and process the data with AI to provide access to hidden sources of knowledge. At the pedigree level, breeding companies use the data to develop the next generation of poultry with better quality. At the commercial level, we automatically classify eggs according to different criteria, including fertilization status, inner quality, and the sex of the developing embryos. We can prevent the waste of billions of eggs, dramatically increase hatchability, and stop the culling of male layers - transforming poultry into an efficient, sustainable, and animal-friendly industry.

Keywords: engineering and technology,magnetic resonance imaging,digital services
Customised membranes for green and resilient industries (CUMERI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Belgium,Germany,Spain,Netherlands,Türkiye,Norway,France,Switzerland
Call: Membranes for gas separations - membrane distillation (IA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 7235177.5
EU funding (EUR): 6380768.14
Participants: 16
Project status: SIGNED

Increased energy and resource efficiency in industrial sectors is paramount to build a resilient and sustainable future. In this context, the CUMERI project will develop and demonstrate at TRL7 advanced and customised membrane separation systems in two key industries: in the steel sector where H2 will be recovered and CO2 captured in one comprehensive system, and in the O&G industry where a two-step liquid filtration system will enable base oil and additives recovery from used lubricant oil. To reach these goals, CUMERI gathers 16 partners (7 RTOs and 9 companies including 4 SMEs) and will elaborate in 42 months three impactful membrane technologies: 1) Enhanced bio-based and recyclable polymer membranes for CO2 permeation; 2) Stable and selective SiC/SiCN membranes for H2 recovery, for a better H2 valorisation in the steel sector; 3) Grafted porous ceramic membranes for waste oil purification and additives recovery by ultra-filtration and liquid-liquid membrane contactors. All membrane systems will unlock greater energy efficiency and decreased emissions in their respective sectors. High separation performances together with increased chemical, mechanical and thermal stability will be demonstrated. Moreover, re-usage and recycling of membranes will be validated. Beyond these demonstrations, the project will generate novel insights on membrane separation including a variety of flexible solutions to help industry, the scientific community and policy makers accelerate the rollout of separation technologies. To maximise the impact of CUMERI, other promising separations will be screened and the transferability of results to other industries (refinery, pharmaceuticals, etc.) will be ensured. Through its activities, CUMERI will pave the way to decreased emissions in the industry, to the greater valorisation of valuable chemicals, and to more energy-efficient processes, promoting resilient and circular industrial value chains.

Keywords: membrane separation,advanced materials,resilient,steel industry,re refinery,pilot demonstration,techno economical and social assessment
The first wide range flow sensor to unlock microfluidic cell analyses for preclinical studies (GALILEO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 1667500.0
EU funding (EUR): 1667500.0
Participants: 2
Project status: SIGNED

There is a critical need to improve the diagnosis, drug discovery and development pipeline to increase the success rate of new therapeutics (as low as 3.4% for cancer drugs) and provide earlier detection and treatment. Microfluidic cell-based assays and analyses are one of the most promising strategies, supported by direct feedback from industry and regulatory agencies. Integrated microscale fluidics adds an extra dimension to in vitro cell cultures and is an enabling technology of single cell analyses and nanotherapies. However, the main limitations with these platforms expressed by our clients from academia and industry are their inability to measure and control flow rate over a wide enough range (100-times too narrow), imprecision and failure to detect sensor drift that leads to experimental error. Our GALILEO flow sensor innovation demonstrates the technical ability to address these pressing requirements for microfluidic cell assays and analyses. This proposal will advance the proof of concept to a viable demonstrator of the technology for beta testing. The timing is ideal for our solution: expressed end user demand is high and legislative bodies have voted to reduce animal testing by 2035. GALILEO has strong competitive advantage in the microfluidic flow sensor market with a SAM of 535 mil EUR/year, increasing with the growth of next-generation sequencing and genomic medicine. Elvesys is an entrepreneur-led microfluidics instrument company with demonstrated success in the development and commercialisation of 15 instruments for microfluidic flow control, and the generation of 10 growing spin-offs in the last 11 years. Our end user feedback and iterative testing approach to innovation puts us in a position of strength to execute an optimal product-market fit, targeting market creation. We have the proven technical expertise to deliver on GALILEO performance, and the market contact breadth to disseminate, exploit and communicate the technology to all stakeholders.

Keywords: microfluidics,microfluidic flow sensor,microfluidic cell culture,flow control,demand driven technological and market creating innovation
High-Fidelity Quantum Computing with Carbon Nanotubes (HiFiQC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3570000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: CLOSED

C12 Quantum Electronics builds reliable quantum processors powered by the most elementary material: carbon nanotubes. By utilizing single-electron spins hosted in suspended ultra-clean carbon nanotubes, we achieve the closest realization of an ideal qubit in vacuum. We integrate the nanotubes onto semiconductor chips thanks to our proprietary high-throughput technique. Any qubit can be coupled to any other qubit through a custom microwave resonator. Thereby, we achieve scalable & ultra-coherent quantum processor architecture with isolated yet easily addressable qubits. Our carbon nanotube based technology can scale quantum computing, in the vein of what silicon did for classical computing. Combining the purity of carbon nanotubes and well-established semiconductor manufacturing, our innovation has the potential to process quantum information at large scales with the highest fidelity. Thus, our quantum computers can solve complex problems beyond the reach of any classical supercomputer.

Keywords: carbon nanotubes,micro system engineering,quantum computing,nanotechnology,nano materials,nano engineering
In Silico Clinically-Viable Assistive Tools for Prediction and Rehabilitation of Knee Osteoarthritis (CARE-KNEEOA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 302331.36
EU funding (EUR): 302331.36
Participants: 2
Project status: SIGNED

Knee osteoarthritis (KOA) is a leading cause of disability worldwide, with ~14% prevalence in Europeans aged over 40. KOA prevalence continues to rise, thus far, with no cure or proven prevention protocols. Nonetheless, an aberrant knee mechanobiological environment is known to accelerate KOA development. Tailored rehabilitation, aiming to favorably alter knee biomechanics and restore the joint, has shown great potential to postpone or decelerate KOA progression. But current rehabilitation protocols are based on indirect measures of knee biomechanics, often leading to suboptimal outcomes. Computational models have offered great potential for simulating knee mechanical response in functional activities, though none are developed in a holistic and individualized context. More importantly, they lack the prediction capability of tissue degeneration/regeneration to loading and the potential for clinical use, i.e., are not automated and fast and cannot use out-of-lab motion data. In this project, I will develop and validate highly personalized in silico tools to quantify knee cartilage mechanobiological degenerative/regenerative response geared towards out-of-lab and clinical use for predicting KOA progression in different functional activities, allowing personalized rehabilitation. The multiphysics computational models, assisted with artificial intelligence (AI), will be validated at different spatial scales using in vitro tissue and cell level experiments and in vivo joint loading and quantitative medical images. This multidisciplinary project bridges together complementary skill sets of Dr. Esrafilian, Profs. Korhonen’s and Delp’s teams, with their expertise in biomechanics, computational modeling, biochemistry, biology, and AI. The beyond state-of-the-art models of this research can make a profound impact on early-stage KOA prediction and treatment planning, potentially increasing the quality of life in KOA individuals and reducing the need for surgical interventions.

Keywords: articular cartilage,knee osteoarthritis,finite element modeling,neuromusculoskeletal modeling,artificial intelligence,image processing,mechanobiology,predictive model
Composite Silicon/Graphite Anodes with Ni-Rich Cathodes and Safe Ether based Electrolytes for High Capacity Li-ion Batteries (SiGNE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Ireland,Germany,Spain,Ukraine,Italy,France,Latvia,Austria,Poland
Call: Advanced high-performance Generation 3b (high capacity / high voltage) Li-ion batteries supporting electro mobility and other applications (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2027-02-28
Duration (months): 54.0
Total project cost (EUR): 7979282.5
EU funding (EUR): 7979282.5
Participants: 17
Project status: SIGNED

SiGNE will deliver an advanced lithium-ion battery (LIB) aimed at the High Capacity Approach targeted in this work programme. Specific objectives are to (1) Develop high energy density, safe and manufacturable Lithium ion battery (2) optimise the full-cell chemistry to achieve beyond state of art performance (3) Demonstrate full-cell fast charging capability (4) Show high full-cell cycling efficiency with >80% retentive capacity (5) Demonstrate high sustainability of this new battery technology and the related cost effectiveness through circular economy considerations and 2nd life battery applications built upon demonstrator and (6) Demonstrate high cost-competitiveness, large-scale manufacturability and EV uptake readiness. SiGNE will achieve these objectives by incorporation of 30% Si as a composite where it is electrically connected to the Graphite in nanowire form. This will realise a volumetric ED of >1000 Wh/L when pre-lithiated and paired with a Ni- rich NCM cathode optimised to deliver 220 mAh/g. This will be further enabled by a specifically designed electrolyte to maximise the voltage window and enable stable SEI formation. A sustainable fibre based separator with superior safety features s in terms of thermal and mechanical stability will be developed. SiGNE will establish the viability of volume manufacturing with production quantities of battery components manufactured by project end. The battery design and production process will be optimised in a continuous improvement process through full cell testing supported by modelling to optimise electrode and cell designs through manufacture as a 21700-type cylindrical cell and prototype testing at by OEMs. (SOH) monitoring across the entire battery lifecycle will optimise safety 2nd use viability. SIGNE will go significantly beyond SoA with recovery of anode, cathode and electrolyte components. In this circular economy approach recovered materials will be returned to the relevant work package to produce new electrodes.

Keywords: silicon nanowires,graphite anode,single crystal ni rich nickel cobalt manganese oxide cathode,glyoxyal electrolyte
Chromatic Algebraic Geometry (AlgChrom)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SUSPENDED

Stable homotopy theory provides a powerful framework for the study of algebra in the homotopy coherent setting. Its central notion is that of a spectrum, which is the homotopical generalization of an abelian group. Spectra appear naturally in a wide range of mathematical fields from number theory to differential topology, as they encode in a highly structured fashion various fundamental invariants, such as the algebraic K-theory groups of a ring and the cobordism classes of manifolds. The tools of stable homotopy theory have thus found remarkable applications in both algebra and topology, as well as in symplectic geometry, mathematical physics and more. The prevailing, and highly successful, paradigm in stable homotopy theory is the chromatic approach, which gives rise to an infinite family of “intermediate” characteristics interpolating between 0 and p, allowing one to implement local-to-global methods in homotopical settings. In this proposal, I shall describe several interrelated projects, with two unifying themes: The study of the intermediate characteristics using higher semiadditivity, and the import of ideas and tools from algebraic geometry to study both the local and global aspects of the chromatic approach. The preliminary results already provide significant advances on some of the central problems in stable homotopy theory, such as the chromatic redshift conjecture in algebraic K-theory, the construction of E∞-orientations, and the chromatic splitting conjecture. Furthermore, they facilitate partial computations of the Galois, Picard and Brauer groups in the intermediate characteristics.

Keywords: chromatic homotopy theory,stable homotopy theory
Sustainable and Ecosystem-based Approach for Fisheries through the Utilization of Technology to Uphold Resilient Environments (SEA4FUTURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Spain,Italy,Türkiye,Greece,Netherlands,Portugal,France,United Kingdom,Germany
Call: Atlantic and Arctic sea basin lighthouse, Mediterranean Sea basin lighthouse, Baltic and North Sea basin lighthouse - Reducing the environmental impacts of fisheries on marine species and habitats (HORIZON-MISS-2024-OCEAN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 8525944.35
EU funding (EUR): 7999200.26
Participants: 22
Project status: SIGNED

SEA4FUTURE is dedicated to catalysing a blue transformation in the Mediterranean's seafood sector, addressing environmental degradation and socio-economic vulnerability, while leveraging successful practices from Madeira. From citizen science to best practices design, fishers are central actors of the project. SEA4FUTURE will develop a multi-scale set of tools, devices and gears to increase selectivity, and reduce bycatch. SEA4FUTURE also acknowledges the critical role of Marine Protected Areas and Fisheries Restricted Areas in fish stock recovery. By integrating MPA/FRAs management with advanced modelling practices, the project aims to boost the effectiveness of these protected zones and co-design new ones. Crucially, SEA4FUTURE will engage with local communities in the co-design of science-based solutions, filling critical knowledge gaps and ensuring that innovations are culturally and contextually appropriate.This approach aligns with broader conservation goals, ensuring that the Mediterranean remains a vital source of food and economic activity for future generations. SEA4FUTURE will address the rest of the seafood value chain by benchmarking existing certification schemes and auditing non-sustainable fisheries providing tailored roadmaps. The project aim at increasing sustainable seafood visility by directly targeting seafood buyers through knowledge sharing, dedicated content and events with fishers.

Keywords: citizen science trawlers small scale fisheries gears edna genomics dynamic modelling mpas participative fuel efficiency acoustic deterrent vulnerable species nursery grounds