Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EVidenced based management of hearing impairments: Public health pΟlicy making based on fusing big data analytics and simulaTION. (EVOTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Poland,Greece,Poland,Bulgaria,Croatia,Switzerland,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Big Data supporting Public Health policies (H2020-SC1-2016-CNECT, 2016)
Start date: 2016-11-01
End date: 2020-01-31
Duration (months): 39.0
Total project cost (EUR): 5421901.25
EU funding (EUR): 4963776.25
Participants: 14
Project status: CLOSED

Hearing Loss (HL) is one of the most prevalent chronic diseases and the 5th cause of disability. HL increases the risk of cognitive decline, mental illness, and depression, and leads to social isolation, unemployment/early retirement, loss of income and work discrimination. The pre-eminent management strategy for HL is the provision of Hearing Aids (HAs), although their use is often problematic, costly and with poor overall benefits. The holistic management of HL requires appropriate public health policies for HL prevention, early diagnosis, long-term treatment and rehabilitation; detection and prevention of cognitive decline; protection from noise; and socioeconomic inclusion of HL patients. However, currently the evidential basis for forming such policies is limited. Holistic HL management policies require the analysis of heterogeneous data, including HA usage, noise (TTS) episodes, audiological, physiological, cognitive, clinical and medication, personal, behavioural, life style, occupational and environmental data. EVOTION has access to big datasets of such data from five different organisations and will support their continuous update by real time data produced by sensors and HAs used by HL patients. To utilise these data in forming holistic HL management policies, EVOTION aims to develop an integrated platform supporting: (a) the analysis of the above datasets to enable the identification of causal and other effects amongst them, (b) policy decision making focusing on the selection of effective interventions related to the holistic management of HL, based on the outcomes of (a) and the formulation of related public health policies, and (c) the specification and monitoring of such policies in a sustainable manner. To achieve this aim, EVOTION also brings together public health policy organisations, experts and authorities supporting the formation of the targeted policies and the validation of the EVOTION support for it.

Keywords: public health policy,big data analytics,simulation,evidence based health management,hearing impairment
TEMPERATE WELDING (TEMPERATE CO2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain,Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Develop a complete, highly efficient MIG-MAG welding equipment (600 A, 30 kW) with unity duty cycle factor, entirely designed to fulfill the needs in the metalmechanical sector. Additionally it offers considerable advantages in automated applications. A ground-breaking power supply technology developed by DEGIMA in collaboration with the University of Cantabria will be at the foundation of this new equipment. DEGIMA owns the European Patent of the power supply technology (EP 2 286 949 A1 /2011): Electronic system for optimizing energy transfer for welding equipment. Despite the advances in new inverter systems, current welding equipments require lots of power, overheat the workpieces and generate sparking that produce defects in the weld line. This new technology significantly reduces power use and CO2 emissions, keeps heat input to the workpieces to a minimum, provides full control of the welding parameters and avoids sparking and projections producing a weld line that is completely steady. This results in a faster welding process that yields a longer weld per unit of time and per volt-ampere used. Each one of this new welding equipment could save up to 20.000 kWh per year, which multiplied by the expected accumulated number of units sold by the 4th year yields savings reaching the 145 million kWh. With the help of this technology brought forth by DEGIMA and GALA GAR (partner and welding equipment manufacturing company), Europe can lead the third generation of welding equipment, much highly energy efficient than the previous, which will grant competitive advantages to all sectors involved into intensive welding activities. It is only a matter of time for the majority of welding equipment to be energy efficient. Reducing emissions of greenhouse gases would be awesome Our first target clients will be the automatic MIG welding process from metalmechanical companies which we plan to approach with commercial actions and demonstrations of the qualities of this equipment

Keywords: welding technology,inversor resonant,energy efficiency,low carbon emisions
How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer (PhaseControl)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2025-04-30
Duration (months): 78.0
Total project cost (EUR): 1997840.0
EU funding (EUR): 1825340.0
Participants: 2
Project status: SIGNED

The progression from a healthy liver towards non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) serves as a model for chronic diseases in a solid organ, demonstrating how an initially stable stage undergoes critical transitions along several defined phases. Defining the molecular drivers of these phase transitions will open the road for the definition of warning signs, risk prediction approaches and prevention of disease decompensation in human liver disease. We recently made several ground-breaking findings indicating that the molecules RIPK3 and MLKL – which regulate a novel form of programmed cell death called necroptosis – are crucial mediators of these phase transitions, but they might have unexpected and cell-death-independent functions. Therefore, PhaseControl aims at exploring the specific functions of these molecules at the critical phase transitions towards NASH/HCC. Specifically, I propose to apply a systematic approach and innovative methods to 1) explore cell-type specific RIPK3- and MLKL-dependent regulatory networks in white adipose tissue (WAT), hepatocytes and myeloid cells in murine NASH development and define cell-death independent functions of MLKL in metabolic regulation; 2) explore how inflammatory pathways in hepatocytes modulate the reactivity and specific responses towards necroptosis at the transition towards hepatocellular carcinoma (HCC); 3) examine apoptosis- and necroptosis-specific genetic alterations and driver mutations that mediate the transition from chronic inflammation to HCC; 4) evaluate in a cohort of human patients if these newly discovered pathways can be used for risk-prediction approaches and might be chemoprevention targets against HCC. The expected results will establish a novel concept how programmed cell death, inflammation and metabolic pathways functionally interact in hepatocarcinogenesis with fundamental relevance for risk prediction and chemoprevention of human liver cancer.

Keywords: non alcoholic fatty liver disease,nafld,non alcoholic steatohepatitis,nash,hepatocellular carcinoma,liver,liver cancer,cell death,alarmins,necroptosis,apoptosis,ripk3,mlkl
The advantages and pitfalls of elicitated online user engagement (TheSocialBusiness)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

The notion that websites benefit when their users are socially engaged—i.e., when they interact with content and with other users—has become so entrenched it is practically an axiom. Accordingly, websites in numerous domains invest heavily in ‘social computing’ features that encourage such engagement. In fact, many attempt to elicit engagement proactively, through the use of calls to action—prompts that ask users to carry out participatory actions such as rating or ‘liking’ content. Given the vast popularity of social computing, it is surprising how little we actually know about how user engagement affects websites and their users. From a business perspective, the direct value of user engagement is far from clear. From a societal perspective, it is unclear whether the increasing expectation for users to engage with firms may lead users to behave in ways that do not serve them. This research aims to provide a comprehensive understanding of user engagement, and specifically, engagement elicited by calls to action, from those two perspectives. I will use an empirical approach, relying on innovative lab and large-scale field experiments. The lab experiments leverage a specially-designed website. For the field experiments, we will collaborate with websites spanning several domains; we have already initiated a relationship with a leading website-development service provider that uses a freemium business model, and have been able to observe the actual behavior of its users. Our preliminary results are promising, supporting the idea that calls to action have strong effects on conversion and information revelation. Moving forward, I plan to fully characterize the nature of these effects in multiple product domains, and to isolate their underlying mechanisms. I am confident that this research program will transform our understanding of the economic and broader societal impact of the social computing phenomenon.

Keywords: electronic commerce,social media,online business models,privacy
Application of Cold Plasma Treatment for Antimicrobial Contact Lenses (MePlat)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Italy
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

While the market of contact lenses has evolved over the years, there still remains a need for contact lenses which inhibit or do not promote bacterial and microbial growth or adhesion to the surface of the lenses, while simultaneously being safe for the wearer. Our company has identified a business opportunity based on cold plasma technology which will revolutionise the contact lens market.. We have the ability to modify the surface properties of the contact lens, to increase resistance to the attachment of bacteria, making the contact lens safer. Through our technology we will also increase the comfort of the contact lens by adding an aqueous layer which will reduce the chances of the lens drying out. Based on successful clinical studies, the grafting of heparin to the surface of the contact lens, will decrease contact-lens-related morbidity. Heparin is a glycosaminoglycan and when exposed to a substrate (sulfur salt in our case), forms a molecular layer of water that prevents attachment of bacteria to the surface via adhesins . The possibility of grafting heparin directly to the surface of the contact lens will provide a much safer and more comfortable solution to contact lens users, one which lasts throughout the lifetime of the product. With our process, we aim to disrupt the industry and drastically reduce incidents of severe eye infection resulting from inappropriate contact lens use and care. Furthermore, we aim to increase customer retention and reduce the dropout rate by making contact lenses more comfortable for the users, adding more relief and reducing instances of dryness and discomfort. The project proposal MePlat was submitted in September 2016 and received a score of 13.71, surpassing all thresholds (4.62 Impact, 4.52 excellence, 4.57 Implementation). We strongly believe in the potential of our project and after studying closely the ESR and discussing the project with our contact point, we are hereby putting forward a revised resubmission.

Keywords: cold plasma technology,rafting,contact lenses,vision market,heparin,antimicrobial coating,industry
EXamining CHemistry and Nanoparticle Geometry Effects at the INterface of Liquid CrystalS (EXCHANGE_inLCs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

The organization of nanoparticles is important for tuning material characteristics, impacting electronic and optical properties. Systems in nanotechnology are reliant upon self-assembly. Recently, liquid crystals, famous for displays, have been employed to self-assemble particles, due to the medium’s ability to form complex patterns. However, the exact interactions between nanoparticles and liquid crystals at the submicron scale remain ambiguous. EXCHANGE_inLCs seeks to elucidate particle-liquid crystal interactions at the submicron scale, by EXamining CHemistry and Nanoparticle Geometry Effects at the INterface of Liquid CrystalS through: 1) varying system GEOMETRY to elucidate the impact of confinement, particle size, and shape, and 2) varying system CHEMISTRY to clarify the activity of certain chemical species around particles. The project will be performed at Utrecht University, where the host has expertise in nanoparticle assembly and light nanoscopy. By varying system length scales and types of surface treatments, key interactions can be isolated. The project will facilitate the following two-way transfer of knowledge between the host and me: A) The host has innovated methods of functionalizing, manipulating, and imaging particle assemblies, down to the single-particle resolution. Both skills are essential for me to investigate my systems at a challenging length scale where both chemistry and geometry can be equally influential. B) The host has a history of exploring the ordering of rod-like particles (colloidal liquid crystals), and my expertise in patterning rod-like molecules (molecular liquid crystals) would complement their body of knowledge. We share a mutual interest in interparticle interactions and their effects on self-assembly. The project combines our areas of expertise to advance fundamental knowledge of nanoparticle self-assembly in anisotropic fluids, essential for developing new bottom-up approaches in nanotechnology, a European priority.

Keywords: liquid crystals,nanoparticles,self assembly
Novel device for simple and effective prevention of post-surgical adhesion build up. (FuseX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Surgical adhesions are a consequence of abdominal trauma during surgery. Although there are a multitude of available barriers on the market today, the efficacy of these solutions is still in question and can lead to adverse side effects. If untreated, these surgical adhesions can solidify and grow, potentially leading to infertility, chronic pain, and difficulties in repeat operations. To address adhesions, patients must undergo additional abdominal surgery, putting unnecessary stress on existing healthcare systems. On average, 35% of patients who undergo open abdominal or pelvic surgery are readmitted twice in the following 10 years due to complications. EIO Biomedical has developed a revolutionary anti-adhesion system in order to eliminate initial formation of surgical adhesions. The FuseX system, delivers a mixture of donor blood plasma with a concentrated mix of natural coagulation factors found in the blood. This results in less post-surgical adhesions, and related complications, and translates to an estimated 6-12 B€ in saved expenses per year. Preliminary testing of the material demonstrated a 60-90% reduction of adhesions, depending on the severity, whilst the non-invasive laparoscopic application also reduced open wound size and extent of trauma. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project, EIO Biomedical is set to initiate safety and efficiency trials in Lithuania and Spain, where they will initially market their product. After initial testing, device function and efficiency will be further improved to enable a more rapid procedure for scale up to commercialization. Post-commercialization, CEO Dr. Yair Pilpel hopes to integrate anti-inflammatories, pain killers, and antibiotics, into the solution for widespread use in hospitals, clinics, and potentially schools.

Keywords: surgical adhesions,all natural,trauma,abdominal,non invasive laparoscopic,repeat operations
Tracing language and population mixing in the Gansu-Qinghai area (TRAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany,China,France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2027-06-30
Duration (months): 78.0
Total project cost (EUR): 2497850.0
EU funding (EUR): 2028624.76
Participants: 4
Project status: SIGNED

Chinese history was co-constructed by Han (Chinese) people, transmitters of farming language and culture, and non-Han people, typically transmitters of nomadic language and culture in North and Northwest China. Governance by non-Han steppe rulers lasted for almost ten centuries (half of the history of imperial China since the First Emperor of Qin) and the Gansu-Qinghai area was the most important migration corridor between Central and East Asia. These languages and populations have competed, mixed and merged for ages. Surprisingly, a cross-linguistically comprehensive portrait of this region is missing in spite of individual language descriptions. The present Project will study language mixture and language replacement patterns in the Gansu-Qinghai area, which geographically constitutes a natural demarcation between nomadic herders and farmers. In this intense contact area, home to nomadic languages and populations, Sinitic (Han) languages started to resemble non-Han languages, adopting similar syntactic means, while Yugur languages (Western Yugur belongs to Turkic language group and Eastern Yugur belongs to Mongolic language group), spoken by typical nomadic populations, kept their syntax relatively intact. The mixing degree of languages and populations in this area remains unclear, and in-depth research with an interdisciplinary approach is necessary. The Project will determine the linguistic situation in this anthropological corridor by targeting two nomadic languages (Western and Eastern Yugur) and a variety of Sinitic languages. The analysis of language mixing and language replacement processes will be based on quantified data modeling, part of which will come from molecular anthropology and other fields such as history and archeology. This interdisciplinary approach will offer a global vision of language and population mixing in the Gansu-Qinghai area and a living sample of language preservation or loss due to different lifestyles and cultures.

Keywords: populations,anthropolgoy,language contact
Impact of vector-mediated transmission on the evolution and ecology of a bee virus (BeePath)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany,United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1999531.0
EU funding (EUR): 1857780.0
Participants: 2
Project status: SIGNED

The emergence of novel transmission routes is likely to have profound impacts on the ecology and evolution of infectious diseases, with potentially dramatic effects on host populations. This might be particularly drastic when transmission changes from direct to vector-borne transmission, where prevalence and virulence are expected to increase. Despite its importance for disease control, we lack empirical and theoretical understanding of this process. The emergence of Varroa destructor in honeybees provides a unique opportunity to study how a novel vector affects pathogen ecology and evolution: this ectoparasitic mite is a novel vector for Deformed Wing Virus (DWV), a disease linked to severe increases in hive mortality. To study the fundamental evolutionary ecology of emerging vector-borne diseases, I will exploit a unique natural experiment, the presence of Varroa-free island refugia, to test how this novel vector affects epidemiology and evolution in the field. I will adapt cutting-edge single molecule sequencing to guide controlled lab experiments by viral evolution in the wild, establishing novel reverse genetics approaches in DWV to test causal links between phenotypic and molecular evolution. Like all emerging diseases, DWV is a multi-host pathogen that also infects wild bee species not infested by Varroa, such as bumblebees. This raises an additional question, highly relevant for zoonotic diseases: does this specialist honeybee vector impact disease in wild bee populations? I will model the impact of vector acquisition and evolving pathogens on host populations and test potential prevention and mitigation strategies to safeguard these crucial pollinators. This system will not only provide fundamental insights into the evolutionary ecology of disease, but is also of immediate applied importance: bees are key pollinators of crops and wildflowers, and halting population declines facilitated by infectious disease is crucial for food security and biodiversity.

Keywords: vector,transmission,virulence,emerging diseases,pollinators