Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Facilitating the next generation of effective and intelligent water-related policies utilising artificial intelligence and reinforcement learning to assess the water-energy-food-ecosystem (WEFE) nexus (NEXOGENESIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Italy,South Africa,Germany,Spain,Italy,Italy,Germany,Belgium,Greece,Greece,Sweden,Bulgaria,Greece,Romania,Latvia,France,France,France,Netherlands,Netherlands,Netherlands
Call: Understanding climate-water-energy-food nexus and streamlining water-related policies (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 4998625.0
EU funding (EUR): 4998625.0
Participants: 21
Project status: SIGNED

Water, energy, food, and ecosystems (WEFE) are interconnected, comprising a coherent system (nexus) dominated by complexity and modulated by climatic and socio-economic drivers. Resource constraints, and their interconnectedness could hamper economic development, including optimal trade, market and policy solutions. Moreover, policy objectives tend to be developed with little consideration to multiple sectors, and policy implementation may change nexus characteristics, in turn affecting actor behaviour and policy formulation. NEXOGENESIS will develop and validate: (a) a coherent cross-sectoral policy-making framework at different scales addressing climate and socio-economic change, as well as stakeholder behaviour and transboundary (diplomacy) issues, developed for and validated by stakeholders, policy makers, and academics; (b) a Self-Learning Nexus Assessment Engine (SLNAE) exploiting reinforcement learning, and supporting streamlining water-related policies into the WEFE nexus; (c) a WEFE Nexus Footprint, accompanying the SLNAE. NEXOGENESIS will apply its approach to four European and one case study in southern Africa. Through the case studies, strong stakeholder engagement and validation of output, NEXOGENESIS will improve policies and policy making processes to enhance cooperation and help the EU achieve targets related to the Water Framework Directive, the greener CAP, Green Deal ambitions, as well as ambitions on water diplomacy. NEXOGENESIS outcomes, both during and after the project, will have a major impact on advancing nexus understanding and governance, resulting in a more innovative and more competitive European Union regarding nexus policy-making, backed up by state-of-the-art evidence. NEXOGENESIS will continue to drive impact after the end of the funding period through dedicated outscaling and exploitation objectives to maximise future impacts and will bring project results to extended group of users via an innovative stakeholder engagement process.

Keywords: water energy food ecosystem nexus,reinforcement learning,artificial intelligence,complexity science,stakeholder engagement and validation,transboundary,policy streamlining,user validation
Reading of lysine methylation – discovery, biological function and application (KMET-READ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called ‘readers’ (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.

Keywords: histone methylation,lysine methylation,methyllysine readers
Low Dimensional Topology and Singularity Theory (LDTSing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2024-12-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 2
Project status: SIGNED

The aim of the project is two-fold. One goal is to employ techniques from smooth 4-dimensional topology in the study of deformations of isolated surface singularities. More specifically the project aims at advancing in the study of smoothings of rational surface singularities by means of gauge-theoretic invariants as well as lattice-theoretic combinatorial techniques. A conjecture of Kollar regarding a class of rational surface singularities with a unique smoothing will be considered. The conjecture has natural symplectic and topological counterparts. The plan consists in proving the topological version and investigating the extent to which this version of the problem can lead to advancements in the original conjecture. Another primary goal is to investigate properties of the 3-dimensional rational homology sphere group, such as n-divisibility and torsion, via constructions involving rational cuspidal curves in possibly singular homology planes. In this context a first specific goal is producing examples of 3-manifolds which are either Seifert fibered spaces or obtained via Dehn surgery on an algebraic knots which are 2-divisible in the rational homology sphere group. In a similar setting it will be investigated the extent to which rational homology balls bounded by integral surgeries on torus knots can be realized algebraically.

Keywords: homology cobordisms of 3 manifolds,rational surfaces singularities,deformations,rational cuspidal curves
Next-Generation Data-Driven Probabilistic Modelling of Type Ia Supernova SEDs in the Optical to Near-Infrared for Robust Cosmological Inference (BayeSN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2446736.0
EU funding (EUR): 2446736.0
Participants: 1
Project status: SIGNED

Type Ia supernovae (SNe Ia) are used as “standardiseable candles”: their peak luminosities can be inferred from their optical light curve shapes and colours, so their distances can be estimated from their apparent brightnesses. SN Ia distances with high precision and small systematic error are essential to accurate constraints on the cosmic expansion history, local measurements of the Hubble constant, and the properties of the dark energy driving the acceleration, in particular, its equation-of-state parameter w. The current global sample used for cosmology has grown to over a thousand SNe Ia. Future surveys will boost that number by orders of magnitude. However, the constraints on dark energy with the current optical sample are already limited, not by statistical uncertainties from the numbers of SNe, but by systematic errors. Near-infrared (NIR) observations of SN Ia are a route to more precise and accurate distances and significantly enhance their cosmological utility. SNe Ia are excellent standard candles in the NIR, and are less vulnerable to absorption by dust in the host galaxies. These good NIR properties are not exploited by the conventional optical models currently used for cosmological SN Ia analysis. Furthermore, the present useful sample of SN Ia with NIR data is relatively small compared to the growing nearby or distant optical samples. In this Project, we will leverage our involvement in new SN surveys using the Hubble Space Telescope and ground-based observatories to build a ~10X larger sample of SNe Ia with high-quality optical and NIR data. We will develop the next-generation probabilistic model for SN Ia spectral energy distributions (SEDs) in the optical-to-NIR, accounting properly for the variabilities and uncertainties inherent in the data by fusing advanced hierarchical Bayesian modelling and functional data analysis techniques. We will apply our state-of-the-art model to our new SN datasets and LSST to obtain robust cosmological inferences.

Keywords: astrostatistics
Real time and online monitoring of the debittering stage in the table olive processing (TELEOLIVA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The world production of table olives has been increasing in the last few years. According to the International Olive Council (IOC), the 2013/2014 season could reach a production of 2.5 million tons of olives, 4% more than the previous season (2012/2013). Although the table olive production process has become a very high-tech industry in some aspects, one of the most important steps in the process, the debittering stage, is still very much based on the tradition, experience and subjectivity of the technicians who are in charge of it. This is mainly because, to date, there is no available system or tool aimed at improving this process. Thus, there is a clear need in the European table olive industry for technological innovations that can improve the table olive manufacturing processes, particularly in the debittering stage. TELEOLIVA, a new debittering-process monitoring system created by Global Olive, proposes a profound, ground-breaking invention that will lead the transformation of the European traditional table olive sector into an innovative, sustainable and optimized one. The system, which is a set of self-developed ICT tools capable of on-line and real time monitoring of the debittering process, aims to improve product quality by objectively determining the optimal duration of the debittering process stage while reducing production costs and reducing waste generation and negative environmental impacts by avoiding unnecessary input utilization. The main objective of this project is to determine the technical feasibility of the TELEOLIVA system at an industrial scale. At the same time, an economic and market feasibility assessment of the new tool will be conducted in order to prepare a business plan. TELEOLIVA´s target market includes all table olive manufacturers, beginning with those in Europe and eventually expanding worldwide. Currently, no high-tech solutions such as the TELEOLIVA system are offered by any competing company.

Keywords: table olives,online and real time monitoring,debittering process
Centre of Excellence for Exascale in Solid Earth (ChEESE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Partnership: HPC PPP (cPPP)
Countries involved: Germany,Germany,Spain,Iceland,Italy,Italy,Spain,Switzerland,Norway,France,France
Call: HPC PPP - Centres of Excellence on HPC (H2020-INFRAEDI-2018-1, 2018)
Start date: 2018-11-01
End date: 2022-03-31
Duration (months): 41.0
Total project cost (EUR): 7683241.25
EU funding (EUR): 7683241.25
Participants: 13
Project status: CLOSED

This proposal aims at establishing a Center of Excellence to prepare flagship codes and enable services for Exascale supercomputing in the area of Solid Earth (SE). ChEESE will harness European institutions in charge of operational monitoring networks, tier-0 supercomputing centers, academia, hardware developers and third-parties from SMEs, Industry and public-governance. The scientific ambition is to prepare 10 flagship codes to address Exascale Computing Challenging (ECC) problems on computational seismology, magnetohydrodynamics, physical volcanology, tsunamis, and data analysis and predictive techniques for earthquake and volcano monitoring. The codes will be audited and optimized at both intranode level (including heterogeneous computing nodes) and internode level on Exascale architecture hardware prototypes (co-design approach). Preparation to Exascale will also consider code inter-kernel aspects of simulation workflows. First, ChEESE will develop Pilot Demonstrators (PD) for scientific problems requiring of Exascale computing on near real-time seismic simulations and full-wave inversion, ensemble-based volcanic ash dispersal, faster than real-time tsunami simulations and physics-based hazard assessments for seismics, volcanoes and tsunamis. Second, pilots will serve to enable services on urgent computing, early warning forecast of geohazards, hazard assessment and data analytics. Selected pilots will be tested in an operational environment and made available to a broader user community. Additionally, and in collaboration with the European Plate Observing System (EPOS), ChEESE will promote and facilitate the integration of HPC services to widen the access to codes to the SE users community. Finally, ChEESE aims at acting as a hub to foster HPC across the Solid Earth Community and related stakeholders and to provide specialized training on services and capacity building measures.

Keywords: exascale,solid earth,code optimisation,services,geohazards
Prototyping 'intime' - a NINAAT-based self testing platform to detect infectious diseases (intime)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Estonia,Germany,Denmark
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 4526324.0
EU funding (EUR): 4526324.0
Participants: 3
Project status: CLOSED

Presented here is the proposal for the project - Homecare test device ‚intime‘ – targeting to bring the first non-instrumented nucleic acid amplification test device onto the market. Market launch will start out with a device for the diagnosis and screening of the sexually transmitted infection Chlamydia trachomatis followed by a multifunctional device including additionally Neisseria gonorrhoeae and Trichomonas vaginalis. This project is the effort of an international consortium of highly professional partners to bring the modular ‚intime’ homecare diagnostic test from a functional model to the final prototype that is ready to be produced and brought to market. SelfD Technologie will lead this consortium and provide the technology for the device, which was already developed and proven to work in a laboratory setting. Now the homecare test will undergo final prototyping with the help of renowned design company wideblue and the experienced injection molding company Recon. This prototype will then be made in a small series production for a thorough analytical and clinical validation that will allow SelfD to apply for the CE mark and introduce the product shortly after the end of the project. The production will be achieved with Recon and the prepared chemical components necessary for the assay will be provided by Bioatlas, a company that SelfD is already engaged in a strategic partnership with. The clinical trial will be executed by the CRO proinnovera and their great experience and connections will ensure a smooth collection of all relevant data. In short, the ‚intime‘ project will propel the novel diagnostic tool for home use onto the market and thus improve healthcare and allow SelfD to launch their first product and position itself as a promising IVD developer.

Keywords: rapid homecare testing,nucleic acid amplification,point of care
agroPastoral Activities and effects on Landscapes and ErOsion dynAmics in the alps: a new insight from Geological appRoaches and lake sedIment DNA (PALEO-AGRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Due to their unique biological and geological resources, mountains have attracted humans since prehistoric times, despite their sensitivity to environmental and climatic changes. Few studies, however, have investigated the detailed history and dynamic of alpine agro-pastoral activities or their impacts on plant cover and erosion. This is largely due to the lack of suitable proxies for human activities in these environments. The PALEO-AGRI project proposes to address this challenge: 1) through the optimization of a powerful and innovative tool, DNA metabarcoding, and 2) its application to archaeological layers and lake sediment archives distributed across elevation and latitudinal gradients in the French Alps in order to investigate how human-climate-environment relations evolved in diversified environments.

Keywords: mountain agriculture history,erosion history,human climate environment interactions,plant cover changes,ancient dna,dna metabarcoding,geographical information system gis
Wool Worked Worlds - Studying industrial landscapes through collaborative filmmaking. (WOOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: South Africa,Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-12-31
Duration (months): 36.0
Total project cost (EUR): 230352.96
EU funding (EUR): 230352.96
Participants: 2
Project status: SIGNED

This study anthropologically investigates tensions within the transnational wool industry, a commercial network that emerged from European colonial projects that distributed sheep to the Global South’s grasslands. Wool production is an industry with a key paradox: it is highly industrialised yet cannot be detached from place-specific ecologies and social relations. Wool sheared from sheep is materially shaped by the geopolitical and ecological particularities of the grasslands where they are raised. This study explores 1) how these local diversities shape the global wool industry, 2) how local sheep rearing and landscape management practices are shaped by practitioners’ imaginaries of geographically distant parts of the wool industry. It develops a bottom-up approach to studying supply chains, attending to situated perspectives and knowledges of actors in three wool regions: Patagonia, Australia and South Africa. The approach deploys collaborative filmmaking as both method and analytical tool: the project engages sheep farmers, indigenous elderly, laboratory technicians and ambulant sheep shearers in the three regions, and businessmen at the Europe based International Wool Textile Organisation, in describing their version of global wool, analysing their own position within wool networks, and discussing how they understand the ‘globalities’ of the other sites. Building on previous work by the ER and conversations in visual anthropology, the project positions collaborative filmmaking as research practice, not dissemination. It also specifically explores connections and imaginaries that travel directly across the Global South (and not via European centres). Bringing in Global South perspectives, this project disrupts a notion of linear north-south axes and describes how a complex weave of knowledges among grassland regions shapes sheep grazing and landscape management.

Keywords: collaborative filmmaking,environmental anthropology,environmental humanities,landscapemaking,multi sited ethnography,multi species anthropology,visual anthropology,visual methods,wool