Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolutionary Cellular Computing for Environmental Synthetic Biology (ECCO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2131809.0
EU funding (EUR): 2131809.0
Participants: 2
Project status: SIGNED

This project will build living evolutionary cellular computers, and showcase them as intelligent bioremediation agents. Current synthetic genetic networks that perform human-defined computations must remain unchanged—as initially designed—in order to perform well. This is a problem, since biological substrate adapts and evolves, compromising durability, robustness, and computing power. We will exploit the intrinsic dynamic features of living systems. ECCO’s biocomputers will be able self-adapt and reconfigure at run-time. They will show unprecedented levels of robustness and efficiency—far beyond current technological limits. To this end, we will tackle intra-cellular evolvability and multi-cellular reconfigurability. At the intra-cellular level, we will upgrade current genetic circuitry with pre-defined mutation, evaluation and selection dynamics. Circuits will optimise themselves. At the multi-cellular level, we will design cellular consortia able to reconfigure its structure—therefore changing its functionality—according to environmental needs, thus adaptive. The ECCO project will integrate theoretical developments with in-vivo experimentation. The soil bacteria Pseudomonas putida will be used as a host to illustrate the capabilities of evolutionary genetic circuits. To demonstrate long-run efficiency, bacteria will be used to colonize the root of the plant Arabidopsis thaliana—a much more complex environment than the pristine laboratory conditions where circuits are often characterized. Reconfigurability will be achieved by building a multicellular computer able to switch between metal and aromatic removal circuits—two important pollutants. Evolution, adaptation and reconfigurability are elusive to conventional computers; conveniently, these are intrinsic properties of living organisms. The ECCO will benefit from this in order to engineer living computers that unlock applications in novel domains—from synthetic agriculture to precision bioremediation.

Keywords: cellular computing,evolutionary computing,synthetic biology,genetic circuits
Distributed Radar Interferometry and Tomography Using Clusters of Smallsats (DRITUCS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1777525.0
EU funding (EUR): 1777525.0
Participants: 1
Project status: SIGNED

Earth science benefits tremendously from spaceborne synthetic aperture radar. By combining multiple images taken from different angles, we can create accurate digital elevation models and high-resolution tomograms that unveil the three-dimensional structure of vegetation, ice, and dry soil. Whereas today such images are acquired sequentially with conventional satellites, compromising product quality and hindering the monitoring of fast dynamics, DRITUCS envisions distributed sensor concepts to acquire all data in a single pass, paving the way for effective and powerful monitoring of our planet. We exploit clusters of smallsats and build high-quality products from noisy and undersampled data. This makes a key contribution to multi-dimensional imaging theory and represents a paradigm shift from state-of-the-art techniques that demand expensive, high-quality imagery to create digital elevation models and tomograms. Smallsats can be mass-manufactured and lead to low-cost solutions. They are a disruptive NewSpace technology that needs to be complemented by novel distributed approaches to replace and enhance large aperture, high power radar systems. We are pursuing three scientific paths to lay the foundations of a) distributed multi-baseline interferometry, b) distributed tomography, and c) multiple-input multiple-output tomography that takes advantage of waveform diversity to infer unique information about different scattering mechanisms in natural and man-made environments. The elaboration of theoretical models and the development of signal processing algorithms will be complemented by experimental demonstrations with drones. DRITUCS is a giant leap for radar remote sensing with a significant impact on numerous applications. It will pose the basis for future advanced Earth observation missions that will offer remarkable societal benefits and boost European capabilities in the emerging NewSpace sector.

Keywords: synthetic aperture radar,interferometry,tomography,smallsats,drones,distributed concepts
Stratification of Rheumatoid Arthritis: CompuTational models to personalise mAnagement strategies for difFIcult-to-Treat disease (STRATA-FIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Sweden,Austria,Germany,Switzerland,Hungary,Portugal
Call: Computational models for new patient stratification strategies (HORIZON-HLTH-2022-TOOL-12-two-stage, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 5623326.46
EU funding (EUR): 5623326.46
Participants: 11
Project status: SIGNED

Difficult-to-treat rheumatoid arthritis (D2T RA) is an area of huge unmet medical need with major socio-economic consequences for patients and society. Contributing factors have been identified including co-morbidities, drug-related, biological and behavioral factors. However, identifying these patients with specific underlying and overlapping problems, or patients at risk, is a big challenge in practice. Currently, treatment decisions are random and not sufficiently patient tailored nor data-driven. Therefore, the STRATA-FIT consortium sets out to develop and validate computational models to identify and stratify D2T RA patients into clinically relevant phenotypes using real world clinical data. We will also measure biomarkers of inflammation to further characterise these phenotypes. Subsequently, we will execute a pilot study with a clinical decision aid based on our models to assess the effectiveness of personalised treatment strategies. In parallel we will develop a computational model to identify early RA patients at risk of developing D2T RA. By doing so, not only will we provide better treatment for patients with D2T RA, but also work towards its prevention in early RA patients. STRATA-FIT will establish a unique European Learning Healthcare System, using a privacy-proof, state-of-the-art federated learning infrastructure in which patients with, or at risk of D2T RA are identified, stratified and treated in a personalised manner. STRATA-FIT builds on previous work by consortium partners, who initiated and lead the European Task Force on developing points to consider for managing D2T RA. It brings together clinical experts, patient research partners and clinical-, biological-, data- and computer-scientists to tackle this major clinical challenge. When successful, STRATA-FIT will lead to more (cost-) effective D2T RA care and will greatly improve the quality of life of D2T RA patients while lowering the burden of D2T RA on Europe’s health care systems and society.

Keywords: difficult to treat rheumatoid arthritis,federated learning,european learning health care system,real world data,decision aid,stratification,machine learning,clinical prediction modelling
Black hOle Optical-polarization TimE-domain Survey (BOOTES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Greece
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1469875.0
EU funding (EUR): 1469875.0
Participants: 1
Project status: SIGNED

Supermassive black holes form the most intriguing astrophysical systems offering countless opportunities to study fundamental physics in regimes not accessible to laboratories on Earth. Their multimessenger emission manifests in the formation of accretion disks, jets, and the acceleration of extremely energetic particles all of which are still poorly understood. Optical polarization can provide answers to such long-standing black hole physics questions since optical polarization signatures clearly distinguish between competing theories. However, the optopolarimetric data necessary for such a task are missing. BOOTES is a unique joint observational and theoretical program that can unify our understanding of transient (tidal disruption events) and steady (active galactic nuclei) supermassive black hole systems using optopolarimetry. The unprecedented telescope time (109 nights/year) and high-accuracy optical polarimeter available to the proposed work will allow us to produce (1) the first comprehensive optical polarization monitoring of tidal disruption events; (2) the first systematic very-high-cadence optical polarization monitoring of relativistic jets. Having clear polarization expectations from the state-of-the-art models we will uncover two fundamental black hole processes: the accretion disk formation mechanism; the high-energy particle energization process in relativistic jets – two open questions currently at a precipice of a breakthrough in black hole studies.

Keywords: supermassive black holes,accretion disks,jets,particle acceleration
Uncertainty Integration for a Transition in Energy and Sustainability (UNITES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1499347.1
EU funding (EUR): 1499347.1
Participants: 2
Project status: SIGNED

Geopolitical and socio-economic uncertainties are putting the European and Global energy transitions at stake. These deep uncertainties affect the analytical assessments underpinning energy and climate policies. For example, the models used to inform energy planning rely on uncertain forecasts and assumptions for future energy demands, macroeconomic indicators, social acceptance, fuel prices, technology costs, and climate scenarios. Due to fundamental methodological, computational, and data challenges, this uncertainty is at best rarely considered in energy planning, which increases the risk of failing to meet our urgent climate targets. This makes accounting for uncertainty one of the major unsolved problems in energy planning. UNITES addresses these limitations to enable a new paradigm for long-term energy planning. In contrast to current approaches, which try to accurately predict the future, UNITES’ ambition is a systematic integration of uncertainty in energy-climate models. The project will result in three fundamental contributions: (i) theoretical developments to consider different types of uncertainty in energy planning models; (ii) data to quantify and characterize input uncertainties; (iii) AI methods to streamline the complex outputs of uncertainty studies into interpretable policy decisions. The transferable and interdisciplinary developments across the data science, energy, and social sciences domains, unique to Europe and not available in concert elsewhere in the world, will bring about a breakthrough scientific contribution by overcoming important barriers for uncertainty analyses in a wide array of disciplines. The project will also be highly impactful on society, bringing together for the first time quantitative and qualitative dimensions to provide decision-makers with actionable policies to steer the energy transition, which will be central to ensuring that we can meet our climate neutrality targets in the face of a highly unpredictable future.

Keywords: uncertainty energy planning energy transition decision making modeling
AURAL CULTURE: DECODING THE SACRED SOUNDSCAPES OF MEDIEVAL EUROPE (CULT-AURAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-07-31
Duration (months): 25.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Medieval monasteries shaped sacred landscapes of Europe not only visually, but also aurally, with the sound of large percussion instruments – such as bells, matracas, and semantron. Despite they created an authentic aural culture of medieval Europe, the monastic soundscapes remain unexplored. The CULT-AURAL project is interdisciplinary, aiming to explore a novel area of research - the medieval aural culture that infused monastic landscapes, and its role in identity creation. Were the acoustic quality of sacred soundscapes and large percussion instruments relevant for medieval communities? What was the spatial imprint of monasteries’ aural communication? Did male and female monasteries have similar aural imprints in the soundscape? To answer these questions, I will receive training on archaeoacoustic methodology at one of the largest historic soundscape research hubs located at the University of Barcelona, and transversally undertake six case studies in three contrasting regions of Europe – Catalonia, Norway, and Serbia, including male and female monasteries that significantly retained the medieval setting. I will test and document the acoustic properties of soundscapes and large percussion instruments based on the onsite acoustic measurements, explore the audibility of the instruments via the acoustic models, and examine the role of gender through a comparative analysis. I will participate in several research groups for skills and knowledge transfer. Scientific publications for experts and talks for lecturers and students will efficiently disseminate the project’s results. At the secondment (Museum of Cultural History, University of Oslo) I will be trained how to communicate research results to the wide public via multisensory exhibitions, which will also add significant impact to the fellowship. Besides at the new medieval exhibition in Oslo, the results will also be communicated through social networks and public interactive talks in all three countries.

Keywords: archaeoacoustics,soundscapes,medieval monasteries,medieval gender identity,sacred landscapes
Visionary roadmaps: Crafting an Inclusive and Participatory European Democracy with Youth and Communities (Youth for Europe / YOUROPE) (YOUROPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Poland,Netherlands,United Kingdom,Germany,Norway,Czechia,Türkiye,Finland,Spain,Ukraine,Malta
Call: Future scenarios and young visions for European democracy 2040 (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 3999598.75
EU funding (EUR): 3999598.75
Participants: 17
Project status: SIGNED

European democracy is presently challenged by the rise of authoritarianism, political extremism, misinformation, and the decreasing engagement of (underrepresented) youth. YOUROPE addresses the traditionally low political participation rates among, especially underrepresented, youth by tapping into their potential and aspirations through innovative approaches. YOUROPE aspires to transform European citizenship and democracy by enhancing youth involvement, creating a more inclusive democratic process, and developing policies that align with the different needs, perspectives, and ambitions of European youth, especially those who are currently underrepresented. YOUROPE is dedicated to reinvigorating European democracy by enhancing inclusivity and participation, particularly focusing on underrepresented youth and their communities. This is achieved by establishing shared democratic spaces and roadmaps through the innovative 'Community-Led Research and Action (CLRA)' methodology in combination with quantitative methods. This democratic methodology promotes a reciprocal environment of learning and action within educational institutions, recognizing their significant role in advancing European citizenship and democracy. It also ensures that strategies are grounded in evidence, sustainable, iterative, extensive in scale, and fundamentally participatory. Educational institutions are pivotal in this effort, acting as catalysts for democratic engagement. In these settings, young individuals and their communities will collaboratively develop inclusive, participatory democratic spaces and roadmaps. YOUROPE will implement this approach in 21 educational institutions, involving 630 young individuals and 6300 community members, connecting them directly with over 30 European policymakers. The project's vision extends far beyond its immediate timeframe, intending to establish a basis for continuous research and action on future democratic scenarios for Europe.

Keywords: community led research and action,clra,underrepresented youth,inclusive eu policy making,democratic spaces and roadmaps,innovative methodology,educational institutions
Lensless label-free nanoscopy (NaNoLens)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Optical nanoscopy has changed the “seeing is believing” paradigm. This was achieved within a limited field of view (FOV~100µm2) and required fluorescent markers. Large-FOV high-throughput live unimpaired cell imaging is crucial for biology and biomedicine. Hence, improving the space bandwidth product (SBP) using time-consuming scanning stitching is not a good solution. Lensless holographic microscopy (LHM) inherently bypasses FOV limitations by using full sensor-size hologram reconstruction for label-free object information retrieval. Its major limitation, not yet addressed, is its low lateral (~1µm) and axial (~3µm) resolution. I will overcome this fundamental problem by pioneering deep UV (DUV) lensless holotomographic nanoscopy (LHN) as a simple and compact device easily operated inside the cell chamber or outside the laboratory (in contrast to lens-based systems). Owing to DNA damage, DUV is used to sterilize and never image bio-samples. This paradigm will be shifted to provide a breakthrough 10 giga pixel SBP via a low-dose DUV optical-elements-free (no cost, no radiation loss) lensless setup with a worlds-first full-angle tomographic scenario, numerical aperture > 1, and a new class of reconstruction algorithms to decrease the effective pixel (to 100 nm) and remove background noise. I will use LHN to enable the discovery of a new mechanistic understanding of extracellular vesicles expression and intake within large live cell cultures with single-vesicle resolution. EVs, nanosized lipid spheres released by virtually every cell type, are currently emerging as novel disease biomarkers and drug nanovehicles. LHN is a new research field that inherently makes this a high-risk project, but the potential gains are also high as a new era of simple ultrahigh SBP nanoimaging might be opened. The proposed multidisciplinary project calls for near-unique expertise in computational microscopy and digital holography, which I acquired in cooperation with international leaders.
Overcoming criticality for PDEs with randomness (CritPDEsRand)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1496455.0
EU funding (EUR): 1496455.0
Participants: 1
Project status: SIGNED

This proposal is concerned with the study of the dynamics of partial differential equations (PDEs), broadly interpreted, in the presence of randomness, with a particular focus on dispersive equations. This is a young but promising emerging field, and it has deep connections with the more established field of constructive quantum field theory. In recent years, we have witnessed outstanding advances in the theory of singular stochastic parabolic PDEs, and while several breakthroughs have been obtained for the dispersive counterpart, many fundamental questions are still open. In particular, many of these questions are "critical" or "supercritical" according to our current understanding. The main goal of this proposal is to develop novel mathematical ideas and tools to break this barrier of criticality, and provide a resolution to these fundamental problems. Over the last ten years, there has been significant progress at the interface of dispersive PDEs and probability. In my short career, I have been one of the leading figures of this field and I have achieved significant breakthroughs. Particularly, my works on phase transitions for focusing Gibbs measures, ergodicity results for stochastic wave equations and global well posedness result for fractional NLS in negative regularity have opened the door to new exciting possibilities. In this proposal, In this proposal, 1. I will work on the Φ^p_d quantum field theories on R^d, both in the focusing and defocusing regime. This will answer major open questions related to the soliton resolution conjecture and in constructive quantum field theory. 2. I will improve our understanding of how Gaussian measures are transported by the flow of nonlinear PDEs. 3. I will develop a theory of (regular) Lagrangian flows for dispersive PDEs, and use it to break the barrier of criticality for these equations.