Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Training next level scientists and researchers to develop highly selective and safe insecticides (CypTox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Spain,Italy,Belgium,Greece,Switzerland,Greece,Greece,United States,United Kingdom,Mali,United Kingdom,Kenya,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 1380000.0
EU funding (EUR): 1380000.0
Participants: 18
Project status: SIGNED

Some of the most acute challenges that the world faces are caused by insects and mites that seriously threaten human health and food security. Their control is primarily achieved by the use of insecticides: e.g., malaria prevalence has halved since 2000, saving 660 million lives, with 80% of the reduction being attributable to the use of insecticides. However, both limited availability of low risk insecticides (“insecticides that only fight the bad bugs’) and insecticide resistance represent major threats. So, there is an urgent need to develop novel, safe insecticides. Earlier research pointed to a discriminatory role for the enzyme cytochrome P450 (CYP) in the sensitivity to insecticides. CypTox will exploit the CYP metabolic/detoxification pathway of target and non-target organisms, to develop insecticides, efficient against selected insect & mite major pests and vectors, but highly selective and safe for mammals, pollinators and the environment. Outcomes will also include significantly beyond the state of the art biotechnology platforms (high-throughput cell/enzyme- screening assays and in silico pipelines), that will advance research capabilities for future developments of low risk insecticides. CypTox will provide excellent research training within a creative and flexible environment that actively promotes the integration of academic rigor and commercial pragmatism through mobility between sectors and focused training events. The size and balance of a highly motivated consortium (6 AC/6 industrial–of which 3 SME & 3 TC; 300 well distributed secondments), the involvement of experienced PIs in Horizon2020 and ERC projects and the modern communication, dissemination and exploitation approaches will ensure efficient implementation and impact, at several levels. Enhanced career perspectives for scientists and researchers will be achieved by building a sustainable multidisciplinary and inter-sectoral network, integrating world leading researchers and stakeholders.

Keywords: malaria,vector borne disease
Programmable BioMolecular Circuits: Emulating Regulatory Functions in Living Cells Using a Bottom-Up Approach (BioCircuit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2022-01-31
Duration (months): 66.0
Total project cost (EUR): 1887180.0
EU funding (EUR): 1887180.0
Participants: 1
Project status: CLOSED

Programmable biomolecular circuits have received increasing attention in recent years as the scope of chemistry expands from the synthesis of individual molecules to the construction of chemical networks that can perform sophisticated functions such as logic operations and feedback control. Rationally engineered biomolecular circuits that robustly execute higher-order spatiotemporal behaviours typically associated with intracellular regulatory functions present a unique and uncharted platform to systematically explore the molecular logic and physical design principles of the cell. The experience gained by in-vitro construction of artificial cells displaying advanced system-level functions deepens our understanding of regulatory networks in living cells and allows theoretical assumptions and models to be refined in a controlled setting. This proposal combines elements from systems chemistry, in-vitro synthetic biology and micro-engineering and explores generic strategies to investigate the molecular logic of biology’s regulatory circuits by applying a physical chemistry-driven bottom-up approach. Progress in this field requires 1) proof-of-principle systems where in-vitro biomolecular circuits are designed to emulate characteristic system-level functions of regulatory circuits in living cells and 2) novel experimental tools to operate biochemical networks under out-of-equilibrium conditions. Here, a comprehensive research program is proposed that addresses these challenges by engineering three biochemical model systems that display elementary signal transduction and information processing capabilities. In addition, an open microfluidic droplet reactor is developed that will allow, for the first time, high-throughput analysis of biomolecular circuits encapsulated in water-in-oil droplets. An integral part of the research program is to combine the computational design of in-vitro circuits with novel biochemistry and innovative micro-engineering tools.

Keywords: systems chemistry,in vitro synthetic biology,artificial cells,microfluidics
Telemetry and Telecontrol for the Internet of things (IoT) (MIIMETIQ)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2017-10-31
Duration (months): 31.0
Total project cost (EUR): 1431400.0
EU funding (EUR): 1001630.0
Participants: 1
Project status: CLOSED

Machine-to-machine (M2M) is a broad label that can be used to describe any technology that enables networked devices to exchange information and perform actions without the manual assistance of humans. M2M communication is often used for remote monitoring. In product restocking, for example, a vending machine can message the distributor when a particular item is running low. M2M communication is an important aspect of warehouse management, remote control, robotics, traffic control, logistic services, supply chain management, fleet management and telemedicine. It forms the basis for a concept known as the Internet of Things (IoT). The market for M2M will be the fastest growing segment of the IT industry from now until 2017. The M2M market, including technologies related to the Internet of Things, will grow from $44.0 billion in 2011 to $290 billion in 2017. M2M Cloud Factory is a private white label supplier to major manufacturers and system integrators of a M2M / IoT application development framework based on a cloud solution called MIIMETIQ®. MIIMETIQ® is the most flexible, powerful and scalable M2M development framework in the IoT market. MIIMETIQ® provides the highest levels of scalability and security as well as a set of powerful tools on which our customers can quickly build and deliver custom M2M / IoT applications for the most demanding requirements and integrate data into customer key enterprise applications and systems. We have identified two disruptive improvements for our current framework, to both simplify and accelerate the development of M2M and IoT applications which will secure the continuous growth of the company not only on the EU level, but globally.

Keywords: prototyping,machine to machine m2m internet of things iot,development framework,expert system,open hardware platforms
Matter and strong-field gravity: New frontiers in Einstein’s theory (MaGRaTh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom,Portugal
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-12-01
End date: 2021-11-30
Duration (months): 72.0
Total project cost (EUR): 1588817.0
EU funding (EUR): 1305625.0
Participants: 2
Project status: CLOSED

Gravity is the weakest but the most intriguing fundamental interaction in the Universe. In the last decades a formidable intellectual effort has shown that the full-fledged geometric nature of gravity offers much more than a beautiful description and understanding of all stellar and galactic. In the quest for the ultimate theory of gravity, new and spectacular connections between high-energy physics, astrophysics, cosmology and theoretical physics have emerged. Triggered by breakthroughs at the observational, experimental and conceptual levels, strong gravity physics is experiencing a Golden Age, making it one of the most active fields of research of the 21st century. My group in Lisbon has been involved in groundbreaking research into the nature of strong-field effects in curved spacetime with applications in various fields, thus establishing international leadership in the field. This proposal aims at understanding, via perturbative techniques and full-blown nonlinear evolutions, the strong-field regime of gravity, and includes challenging nonlinear evolutions describing gravitational collapse, compact binary inspirals and collisions in the presence of fundamental fields. The proposed programme will significantly advance our knowledge of Einstein's field equations and their role in fundamental questions (e.g. cosmic censorship, hoop conjecture, spacetime stability, no hair theorems), but also its interplay with high energy, astro and particle physics (testing the precise nature of the interaction between compact objects and matter --such as dark matter candidates or accretion disks-- and its imprint on gravitational wave emission, understanding gravitational-led turbulence,etc). This is a cross-cutting and multidisciplinary program with an impact on our understanding of gravity at all scales, on our perception of black hole-powered phenomena and on gravitational-wave and particle physics.

Keywords: einstein field equations,gauge gravity duality,black hole physics,gravitational waves
Digital fabrication and integration of Material reuse for environmentally friendly cementitious composite building blocks (DigiMat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The emergence of green and eco-friendly resources, coupled with demands for advanced digital technologies for conceptual structures/designs, are causing changes in the scale and distribution of the construction industry. The increasing resource constraints that the EU is facing strongly affect its competitiveness and the quality of life of individuals. Important gains in resource efficiency can be made by replacing current linear economic models with circular models of production and consumption, which results, at the same time, in a substantial reduction of greenhouse gas emissions. This project will combine multidisciplinary efforts from various subject areas and innovative technology of 3D printing to design and develop an environmentally friendly cementitious feedstock, driven from construction/demolition waste and industrial by-products suitable for the manufacturing of structural load-bearing building blocks. Dr. Chougan (the Fellow) will join Dr. Ghaffar’s (host Supervisor) research team at Brunel University London (BUL), Additive Manufacturing Technology in Construction group. This is coupled with guidance in the form of two secondments at the West Pomeranian University of Technology and Eindhoven Technology University. This project will provide a tremendous opportunity for the Fellow to expand his research career and further outspread his network with academic and industrial stakeholders. The Fellow will be supported throughout by other global-leading academics and non-academic including short scientific visits to Nanesa S.r.l. (Italy), Washington State University (USA), and the University of Rome Sapienza (Italy), all of which will equip him with a unique insight into eco-sustainable cementitious composite formulations for 3D printing in the construction industry. The training will broaden the Fellow’s skills and career prospects in the academic and industrial construction materials and 3D printing technology fields.

Keywords: digital fabrication,3d printing,concrete,environmentally friendly,building blocks,bio based additives,structural performance,rheology,geopolymer,design of experiment
Risk-aware Automated Port Inspection Drone(s) (RAPID)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Germany,Ireland,Belgium,Norway,France,United Kingdom,United Kingdom
Call: Innovative applications of drones for ensuring safety in transport (H2020-MG-2019-TwoStages, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 4997133.75
EU funding (EUR): 4997133.75
Participants: 9
Project status: SIGNED

RAPID will save lives by delivering an early warning system that will detect critical deterioration in transport system infrastructure, while also minimising system disruption and delays to critical supply chains. It will achieve this goal by combining and extending state-of-the-art drone technology to deliver a fully automated and safety assured maintenance-inspection (MI) service for bridge inspection, ship hull surveys and more. By combining self-sailing unmanned surface vehicles (USV) with swarms of autonomous unmanned aerial systems (UAS), RAPID will dramatically cut the time and cost of structural condition monitoring. RAPID-enabled MI services will increase efficiency and competitiveness for maritime transport stakeholders – such as ports, shipping companies, and landside transport authorities – and will deliver the safe and seamless operation of supply chain and mobility infrastructures – such as material handling equipment, cargo and passenger ships, and bridges. It encourages prioritisation of safer transport infrastructure where the technology seeks to improve environmental impact. The attractive return on investment will enable RAPID to gain market traction and incentivise commercial proliferation, bringing RAPID into widespread use for the overall benefit of society. By 2028, a newly formed company will generate €124 million and save in the order of 100 lives per year (reaching c. 20% share of the serviceable addressable maritime transport market through strategic partnership with 50 ports). RAPID brings together interdisciplinary partners with the expertise and capacity required to develop and validate this unique service model. The project will develop the consolidated maritime and aviation regulation standard for safe USV / UAS operations and the business model to scale the pilot service. RAPID will validate the high level of digitalisation, automation, and regulation required to support safe, beneficial, and scalable access to U-Space.

Keywords: infrastructure inspection,automation,risk management,safety assurance,shipping,ports and harbours,simulation,artificial intelligence,unmanned surface vehicles,unmanned aerial systems,swarms
Regulation of Brain Macrophage Development and Function (MADEFUN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1995500.0
EU funding (EUR): 1995500.0
Participants: 1
Project status: SIGNED

Macrophages are part of the mononuclear phagocyte system and play critical roles in innate immune responses. They further exert crucial organ-specific functions to warrant tissue homeostasis. Most macrophages are long-lived and derive from embryonic precursors. The central nervous system (CNS) contains several macrophage populations, of which microglia are the most prominent and abundant population residing in the CNS parenchyma. Besides being implicated in CNS pathologies, microglia guide neuronal development, are critical for neurogenesis and contribute to the maintenance of tissue homeostasis. At the interface between the brain and the periphery reside choroid plexus, perivascular and meningeal macrophages (‘border-associated’ macrophages, BAMs). While they mostly also originate from embryonic precursors, the differentiation cues and their specific roles in development and in health and disease are poorly understood. Here we will delineate the spatiotemporal emergence of BAMs and microglia, the impact of the local microenvironment on their phenotype and function, and their role in brain development. We will further analyze the role of BAMs and microglia in physiological and neuropathological conditions (neurodegeneration, CNS infection and inflammation). We have recently described a novel ‘microglia-specific’ conditional mouse and we are currently establishing an inducible system to specifically manipulate BAMs. We will use these to genetically intervene in different cytokine signaling pathways in combination with fate-mapping in vivo. The proposed research project will provide a deeper insight into microglia and BAM biology and their functional specializations at different stages of life.

Keywords: macrophage,microglia,brain,development,function
Next-generation Dynamic Digital EPCs for Enhanced Quality and User Awareness (D^2EPC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Austria,Spain,Germany,Germany,Cyprus,Greece,Lithuania,Greece,Greece,Netherlands
Call: Next-generation of Energy Performance Assessment and Certification (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 2993687.5
EU funding (EUR): 2499287.5
Participants: 13
Project status: SIGNED

D^2EPC ambitiously aims to set the grounds for the next generation of dynamic Energy Performance Certificates (EPCs) for buildings. The proposed framework sets its foundations on the smart-readiness level of the buildings and the corresponding data collection infrastructure and management systems. It is fed by operational data and adopts the ‘digital twin’ concept to advance Building Information Modelling, calculate a novel set of energy, environmental, financial and human comfort/ wellbeing indicators, and through them the EPC classification of the building in question. Under the project vision, the proposed indicators will render dynamic EPCs a realistic, accurate and comprehensive tool that can lead the transformation of the European building stock into zero-energy buildings and stimulate energy efficient behavioural change of the building occupants. To this direction, D^2EPC proposes a digital platform that will enable the issuance and update of new EPCs on a regular basis, integrate a GIS environment and provide, on top, value added services including user-centred recommendations for energy renovation, benchmarking and forecasting of buildings’ performance as well as performance verification services. The proposed scheme will contribute to the redefinition of EPC-related policies and to the update of current standards, along with guidance for their implementation and will introduce incentivisation and restriction practices into the EPC rationale. Additional benefits include enhanced user awareness and engagement on buildings’ energy efficiency, facilitated planning and decision making on local and regional policy level. To accomplish the above, the D^2EPC framework will be demonstrated in 6 sites, while its 12 partners coming from 7 European countries will collaborate and provide their expertise and resources within the 36 months of the project’s lifetime

Keywords: next generation epcs,smart readiness indicators,lca and lcc indicators,building digital twin,smart monitoring systems,operational rating
Feasibility study for Grovf hardware accelerated no SQL database for Industry 4.0 (GROVF4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Armenia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the digital world, exabytes of data are collected by manufacturing, energy, telecom companies. The amount of data generated in the past 8 years grew fifteen-fold while datacenters processing power increased only fourfold. According to predictions of IBM, the number of devices that are connected to the internet will increase 7 times in 3 years and will reach up to 50B in 2020. This reality will increase the gap between datacenters processing power and generated data. To solve IIoT data storage and analytics problem companies replicate database servers, which results in complicated infrastructure, increase cost, space, power consumption. A medium European manufacturing company with annual revenue of €50M will spend €158k to implement such solution and €85k annually to support it. Grovf takes another architectural approach to solve the problem and instead of processors, uses FPGAs as a processing unit. GData is growing faster than ever before and by the year 2020, about 1.7 megabytes of new information will be created every second for every human being on the planet . According to a new report from IBM Marketing Cloud, “10 Key Marketing Trends For 2017,” 90% of the data in the world today has been created in the last two years alorovf database server is a first of its kind, dedicated, out of the box, FPGAAccelerated NoSQL database for IIoT sensors generated data. Our prototype already achieved 10x faster transactions and 31x power saving compared with state-of-the-art solutions. The main objectives of the product are: 1. Delivering new, disruptive technology for data management of the IIoT industry 2. Drastically reducing power consumption of the datacenters 3. Providing fast, low cost, reliable local cloud technology for the IIoT industry 4. Optimizing the current loading of the existing datacenters 5. Helping medium-sized manufacturing, energy, logistics, and telecommunications companies to drastically cut costs on IT infrastructure and become more competitive.

Keywords: industry 4 0,nosql,fpga,hardware acceleration,iiot,database,datacenter,big data,data,processing