Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The first natural, scientifically proven, and side-effect free formula for anemia treatment and prevention. (FeJuice)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Serbia
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2023-12-31
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

We are an award winning, female-led, deep-tech start-up. After 10 years of focused research on how foods impact iron absorption in the body, our multidisciplinary team of scientists and entrepreneurs founded FeJuice in 2020. Based out of Serbia, our team aims to commercialise the disruptive application of our discoveries – a novel solution for the treatment and preventing of anemia. Anemia is a disorder in which the blood has a reduced ability to carry oxygen to body tissues due to a reduced number of red blood cells. The most common type of anemia is iron-deficiency anemia or IDA, a condition associated with fatigue, lost productivity, lost cognitive function, and increased morbidity risks. Almost every woman has IDA at least once during her life. With 27% of the population worldwide, or 2.1 billion people, suffering from the condition, we believe each individual should have access to natural and side-effect free treatment and prevention solutions. Our mission is to create a healthier and happier world for the next generation through our natural, scientifically proven dietary formula. FeJuice aims to capture the growing market emerging in the area of functional foods as consumers seek natural and scientifically proven solutions that are side-effect free. Upon launch, FeJuice will disrupt the iron supplement market by effectively eliminating, or greatly offsetting, side-effects patients experience during traditional treatment Our 100% natural solution will work effectively for prevention and treatment of mild anemia caused by lower iron levels if consumed. With most of our funds currently committed to product development activities, the lump sum provided by the Women TechEU programme, combined with the coaching and enhanced visibility, will be fundamental to us overcoming our commercial challenges.

Keywords: anemia
Does exposure to artificial light at night impacts immunity and microbiome in natural populations of an amphibian? (TOADALAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

The constant increase of urbanization and human activities worldwide is exposing animals and human to a multitude of stressful stimuli that disrupt physiological functions in organisms. A major source of pollution nowadays, that affect 99% of the european territory and thus almost every organism in Europe, is light pollution (or ALAN, Artificial Light at Night). Recent studies suggest that the immune function could be strongly disrupted by exposure to ALAN, but these results mostly comes from experimental studies conducted in laboratory conditions, and thus not realistic of real conditions of exposure to the light pollution. Considering the current major biodiversity loss crisis, especially in amphibian taxa, it is crucial to know if the ability of wild organisms to mount appropriated immune respones and control infections is affected by this anthropic source of pollution. Within an eco-immunological and One Health framework, this project has thus been designed to characterize for the first time, and totally in natura, the effects of ALAN on immunity, microbiome composition and infectious phenotype of a common nocturnal Vertebrate, the common toad (Bufo bufo). Using 30 wild populations of common toads living on a natural gradient of exposure to ALAN in a french region, this project will characterize: (i) How exposure to ALAN impact toads’ immune phenotype, using multiple measures to precisely characterize the different immune components that may be differently affected. (ii) How exposure to ALAN impacts toads’ microbiome composition at the two main interfaces of skin and intestinal mucosa, characterizing bacterial and eukaryotic communities. (iii) If toads’ infectious phenotype is dependent of ALAN exposure, immune responses and microbiome composition - focussing on pathogens identified as a threat for amphibians in France.

Keywords: eco immunology artificial light at night microbiome pathogens one health
Ir-Religious MAsculinities: Unpacking the gendered dialectic between Islam and secularism (IRMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 297164.16
EU funding (EUR): 297164.16
Participants: 3
Project status: SIGNED

IRMA breaks new ground and proposes an innovative approach for the relational study of gender by investigating the relationship between masculinity, secularism and religiosity among Bangladeshi-origin Muslim men in different national contexts. An ideological tension between secularism and Islam plays a prominent role in the societal debate on gender, not only in Europe, where "Muslim men" are often a cause for concern, but also in Muslim-majority countries that experienced conflicts between secular state and political Islam, such as Bangladesh. This tension leads most men to frame their identifications according to a polarity between Islam and secularism, and to conceive of their own masculinity as incompatible with that of their counterparts, provoking heated controversy on issues such as gender equality and LGBTQ+ rights, and posing a challenge that has found little response in academic research. Scholars have so far paid scant attention to the topic, producing poor empirical data, and rather devoting themselves to studying "Islamic men" as if they constitute a separate reality from the rest of society. In addition, the scarce research does not consider how migration impacts conceptions of secularism, Islam, and masculinities. IRMA remedies these shortcomings with a multi-sited ethnography on the relationship between secular (irreligious) and Islam-inspired (religious) masculinities in Bangladesh and among Bangladeshi migrants in Italy and Switzerland. The project investigates gender, secularism and religiosity in their interaction with socio-political determinants such as social class and sexual orientation, and with the position of social actors in the geographies of power, in order to offer a more comprehensive understanding of the complex and shifting interplay between secularism, religion and masculinities, and a non-ethnocentric understanding of how secularism and religiosity connect to gender equality and the rights of nonconforming people.

Keywords: masculinity,islam,secularism,bangladesh,mobility,intersectionality
SIGN-IT – Signacula in Roman and Post-Roman Italy: marking religious and cultural identity (2nd-11th c. CE) (SIGN-IT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

The “SIGN-IT – Signacula in Roman and Post-Roman Italy: marking religious and cultural identity (2nd-11th c. CE)” project aims at studying the cultural history of the Italian peninsula from the Roman Imperial period to the central Middle Ages, by means of the objects known as signacula, i.e. matrices bearing text, signs, and/or iconographic motives, designed to stamp various materials. Linguistic choice is one of the main markers of identity : thus, the project focuses on materials found or originally coming from a sample of Italian regions featuring both Latin and Greek speaking communities: Veneto, Emilia-Romagna, Campania, Apulia, Calabria, Sicily, and Sardinia. The historical value of this body of evidence has been hitherto largely neglected due to its difficult dating. To overcome this issue, I will study for the first time the corpus as a whole, from Antiquity to the Middle Ages. The project’s objectives are three-fold: firstly, to establish a clear dating protocol for the signacula to unlock their full potential as historical sources; secondly, building on the newly-dated material, to study the evolving linguistic patterns, and their contribution to the making of specific local identities, between Antiquity and the Middle Ages; thirdly, to track over the “longue durée” changes in marking practices and to analyse them as proxies for cultural transformations. To achieve these goals, I will build up an open-access database gathering published and unpublished signacula pertaining to the chronological and geographical framework under scrutiny. The database’s structure will allow both qualitative and quantitative analysis of the material, and will facilitate comparisons with other types of stamped writing and of inscribed objects (e.g., seals), by adopting and building upon the technical features and norms of the Text Encoding Initiative standard (TEI, https://tei-c.org/), developed for the digital edition of ancient inscriptions (EpiDoc) and seals (SigiDoc).

Keywords: digital humanities sigillography archaeology social practices religious and ritual practices linguistic practices inscribed material culture
Identification and characterization of cellular DeUrmylases (MSCA_dk_2021)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 139953.6
EU funding (EUR): 139953.6
Participants: 1
Project status: CLOSED

Ubiquitin-related modifier 1 (Urm1) is known for its dual role as sulfur carrier protein (SCP) in tRNA thiolation and as an ubiquitin-like protein (UBL) that leads to an oxidant-induced posttranslational protein modification (PTM). We recently, managed to recapitulate the Urm1-conjugation reaction for various targets in vitro and characterize the underlying molecular principles. In most ubiquitin (Ub) and ubiquitin-like- conjugation systems, the active removal of the PTM constitutes a key feature of the regulatory mechanisms. Although, various targets of urmylation have been reported, not a single enzyme that could reverse the modification has been identified. In this project, I plan to incorporate different complementary discovery strategies to ultimately identify possible “deurmylation” enzymes in yeast and human and assess their biological significance. Foremost, I aim to uncover the guiding principles that regulate the evolutionary most ancient UBL system in eukaryotes. Hence, the expected results will not only answer one of the most intriguing questions related to Urm1, but have far-reaching consequences for our understanding of all UBL systems in eukaryotes. Last but not least, several studies hint at the critical function of Urm1 conjugation in oxidative stress response and at its direct involvement in severe human diseases. As various deubiquitylating enzymes (DUBs) are successfully developed as potent targets for small-molecule based drug therapies, the identified enzyme(s) could be well suited for novel therapeutic and diagnostic strategies.

Keywords: urm1,posttranslational modification,protease,activity based probe
BREWERS SPENT GRAIN AS MAIN BY-PRODUCT FOR DEVELOPMENT OF NOVEL, HIGH-PERFORMANCE BIO-BASED POLYMERS, POLYMER BLENDS, AND CO-POLYMERS (POLYMEER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Italy,Belgium,Spain,Croatia,Netherlands,Portugal,Germany,Denmark
Call: Development of novel, high-performance bio-based polymers and co-polymers (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 4878092.5
EU funding (EUR): 4878092.5
Participants: 14
Project status: SIGNED

POLYMEER is dedicated to play a part in establishing a new bio-based value chain for bioplastic products from sustainable sourcing through the effective exploitation of the potential of brewers’ spent grain (BSG) reuse. This entail the efficient conversion of wet BSG into versatile bioplastics tailored for three for three crucial application. These applications are characterized by technical demands that existing bioplastics struggle to meet or where conventional fossil-based plastics still dominate: 1) mulch films suitable for agricultural use, 2) textile for the automotive industry, and 3) tertiary packaging films for industrial purposes, that can be recycled and/or biodegraded in specific environments. The project is a holistic endeavour aimed to achieve this goal. It involves the entire production process, starting with BSG fractionation into key biopolymers, primarily cellulose, hemicellulose, and lignin. These valuable components are then transformed into specific polymers and copolymers exploiting green, waste-minimised processes. Finally, through blending, formulation and processing we will create cutting-edge bioplastics suitable for the designated fields. The most promising results from our lab-scale production will undergo upscaling to demonstrate economic and technical feasibility, paving the way for market launch within 3-5 years post-project completion. Furthermore, we thoroughly evaluate these materials' properties, considering their environmental, social, and economic impacts during large-scale production. We ensure product safety and explore biodegradability potential and recycling processes throughout the production process. In essence, POLYMEER is not just about bioplastics; it's about redefining sustainability in the bioplastics industry with tailor-made solutions derived from BSG.

Keywords: brewers spent grain,polymerisation,pla,vitrimers,agricultural plastics,textiles for automotive,tertiary packaging,biodegradable
Nanopore sequencing of cell-free DNA for the sensitive detection, molecular profiling and monitoring of childhood cancers (PaedsSeq)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 220908.48
EU funding (EUR): 220908.48
Participants: 2
Project status: CLOSED

Paediatric cancer is the leading cause of death in children post infancy in the Western world. The integration of high-throughput molecular profiling is now urgently needed to guide clinical decision-making and treatment stratification. However, access to adequate tumour material for genomic profiling remains highly challenging, particularly in children with refractory cancers, due to sampling difficulties and small sample volumes. The analysis of cell-free DNA (cfDNA) from liquid biopsies for the detection of circulating tumour DNA (ctDNA) could offer a powerful, minimally invasive alternative to tumour profiling, thus circumventing sampling limitations. However, current ctDNA approaches have limited specificity and sensitivity, and their clinical implementation is hindered by poor scalability and high costs associated with conventional sequencing technologies. In contrast, emerging nanopore sequencing platforms have faster turnaround times, are more affordable and significantly smaller than conventional sequencers, making them easy to deploy and implement in healthcare settings. However, their utility for cfDNA analyses remains largely unexplored. Here, using available data and liquid biopsy samples from ~500 children with cancer, I will develop computational tools for the detailed analysis of cfDNA nanopore sequencing data. By harnessing nanopore’s ability to sequence native DNA, thus allowing the detection of mutational DNA alterations and epigenetic modifications from the same assay, I will: (a) establish highly sensitive and specific approaches for the detection and molecular profiling of ctDNA, (b) develop methylation-based disease classifiers for accurate diagnosis and treatment stratification, and (c) evaluate the clinical utility of cfDNA nanopore sequencing to monitor treatment response and detect cancer relapse. The clinical implementation of these approaches could therefore significantly improve disease management and outcomes for children with cancer.

Keywords: cancer genomics,liquid biopsies,cell free dna,paediatric cancer,nanopore sequencing,early detection,copy number aberrations,dna methylation,disease classification
Optical Microscope for Imaging High-Speed Precision Surface Processes (SURFLIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2025-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

SURFLIGHT is at the forefront of optical microscopy innovation, aiming to bring an exceptional microscope to the market. We have developed a high-resolution microscope (up to 2 nm) capable of monitoring ultrafast surface processes (μs-scale) on non-transparent materials under real operational conditions. This innovation holds promise for industries like semiconductors, batteries, and green energy, where it is critical to visualize surface phenomena label-free and in real-time. SURFLIGHT's microscope excels in identifying active sites on surfaces and nanomaterials, essential for catalytic reactions or solar energy conversion. This technology streamlines catalysis R&D by offering real-time visualizations, cutting costs, and optimizing catalyst utilization. Moreover, it minimizes the need for repetitive tests, conserving time and resources, while enhancing catalyst lifespans and reducing replacements through real-time monitoring of catalyst degradation under real-world conditions. Most importantly, it safeguards against large-scale process failures, resulting in substantial cost savings in materials and reduced downtime. A thorough market analysis within SURFLIGHT will allow us to step up our dialogue with academic as well as industrial partners and thoroughly characterize the industry’s demands and needs for the microscope. This will allow us to undertake a final optimization of the microscope once identified the initial targeted customer sector. This ERC PoC will be central for pursuing these goals. We envision SURFLIGHT in the market rapidly and attracting commercial interest from a wide range of industrial sectors.

Keywords: microscopy,surface science,energy,optics
Adaptable multi-pixel gas sensor platform for a wide range of appliance and consumer markets - Hop on (AMUSENS-Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Luxembourg,Greece
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 601242.5
EU funding (EUR): 601242.5
Participants: 2
Project status: CLOSED

The AMUSENS-Hop-On projects will complement the work already planned in the AMUSENS project in the domain of artificial intelligence and in the use case on breath analysis. AMUSENS aims at developing a new multi-pixel gas sensor platform with enhanced selectivity capability using integration of new metal-oxide materials, new production methods from additive manufacturing to make the production more adaptable, as well as the use of artificial intelligence for both material design and for sensor data fusion to adapt it to specific applications. Two end-user applications will demonstrate the applicability of the new platform on monitoring individual exposure to gases and breath analysis for fitness purposes. In AMUSENS-Hop-On, the new partner from a widening R&I country (Greece) will complement project activities by (1) analyzing sensor data produced and developing an AI model supporting optimized sensor calibration, through calibration transfer, by taking into account batch-to-batch variability (2) using the breath analysis sensor developed in AMUSENS in a new application case of personal stress estimation by the realization of experiments in healthy volunteers incorporating ICCS driving simulation laboratory, experienced in conducting (3) complementing the already planned work on AI interpretation by adding model-agnostic interpretability analysis of the AI-based models for calibration transfer and AMUSENS use-case models. Taking advantage of the results of AMUSENS and focusing particularly on the interpretability analysis, the new partner will support the dissemination, communication and knowledge share activities, organizing additional schools/workshops and end-user engagement events, giving special focus on audiences from R&I widening countries as well as other Horizon Europe Destinations in which ICCS is involved

Keywords: multi pixel gas sensor metal oxide gas sensor additive manufacturing inkjet printing local spatial atomic layer deposition mems environmental monitoring air quality health care