Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Mechanisms of Fungal Pathogen Host Interactions (IMRESFUN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria,Germany,Sweden,Germany,United Kingdom,Czechia,Germany,Spain,Hungary,Spain,Denmark
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 3591515.0
EU funding (EUR): 3591515.0
Participants: 12
Project status: CLOSED

ImResFun shall provide state-of-the-art training in infectious disease research and medical immunology targeting the most common human fungal pathogens, the opportunistic Candida species. The key objectives of ImResFun are: (i) to understand how immune cells and infected organs respond to invasion by Candida spp, (ii) to decipher host-defense mechanisms mediating pathogen elimination, and (iii) to identify genetic networks driving the dynamics of host-pathogen interplay. ImResFun will exploit cutting-edge technologies to unravel the basic mechanisms of fungal pathogenesis and host immunity, and to improve diagnosis and identify novel biomarkers of infection. Importantly, ImResFun will translate research into clinical practice and identify potential targets for antifungal drug discovery. ImResFun has seven WPs. In addition to coordination (WP7), research will cover molecular mechanisms of host-pathogen interactions using dual-system infection biology in vitro and in vivo (WP1), clinical patient setting and age-related infections (WP2), chemical biology and antifungal drug development (WP3), and bioinformatics and genome-wide data analysis (WP4). A compulsory and tailor-made practical course (WP5) and complementary skills (WP6) program will boost hypothesis-driven projects. Meaningful exposure to the private sector is ensured by extensive secondments of all ESRs/ERs. The resulting reciprocal technology transfer will be beneficial for both SMEs and ESR/ER hosts and sustain collaborations among partners. ImResFun will use personalized career development plans for each ESR/ER to train entrepreneurial scientists capable of translating frontier research into clinical practice, biotechnology and drug discovery. Taken together, ImResFun offers a best-practice example for interdisciplinary, intersectorial and supradisciplinary training in understanding the immunology of microbial infectious diseases, since most approaches are amenable to other microbial pathogens.

Keywords: infectious disease,biomarkers,diagnostics,immunoproteomics,immune response,host-pathogen relationships,innate immune cells,candida spp,regulatory networks,dual-systems infection biology
High spatial and temporal resolution Ocean Colour coastal water products and services (HIGHROC)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space-based applications at the service of the European Society
Action type: Collaborative project
Countries involved: Belgium,France,Norway,Germany,Belgium,United Kingdom
Call:  (FP7-SPACE-2013-1, 2013)
Start date: 2014-01-01
Duration (months): 48.0
Total project cost (EUR): 3329947.44
EU funding (EUR): 2497909.1
Participants: 7
Project status: CLOSED

The HIGHROC (“HIGH spatial and temporal Resolution Ocean Colour”) project will carry out the R&D necessary for the next generation coastal water products and services from ocean colour space-borne data, giving an order of magnitude improvement in both spatial and temporal resolution and thereby opening up new applications and strengthening existing ones. This responds to SPA.2013 topic 1.1-06 “stimulating development of downstream services and service evolution”. GMES services for marine end-users, e.g. for Water Framework Directive (WFD) reporting , now routinely use data from ocean colour remote sensors such as MERIS and MODIS, to be followed by OLCI. Despite their improved coverage with respect to in situ monitoring, these sensors have critical limitations of spatial and temporal resolution (typically 300m, 1/day) with respect to user requirements. HIGHROC will derive coastal water quality parameters from a) Sentinel-2 (S2) at 10-20m resolution and b) SEVIRI at 15 min resolution, thus complementing OLCI data with a more than 10-fold improve in spatial and temporal resolutions. Theoretical work will consist of developing atmospheric correction and level 2 product algorithms for the S2 and SEVIRI sensors and Level 3 algorithms for multitemporal and synergistic exploitation of the new products with existing products such as those from OLCI and VIIRS. An image processing chain will provide corresponding full mission historical and near real time products for local areas including the dedicated test sites. In situ measurements will be carried out on dedicated test sites and used to validate the new S2 and MSG products. Exploitation of the products will be supported by interaction with user partners and potential user groups with particular focus on the opportunities offered by the new HIGHROC products both for entirely new application areas and for significantly improved spatial and temporal resolution for existing applications, e.g. WFD monitoring and reporting.

Keywords: gmes services,water framework directive,marine strategy framework,ocean colour,sentinel-2,sentinel-3,seviri,geostationary,suspended matter,chlorophyll,diffuse attenuation
Community and Ramp Aircraft NoisE (CRANE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium,United Kingdom
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-11-01
End date: 2017-10-31
Duration (months): 48.0
Total project cost (EUR): 1051408.61
EU funding (EUR): 1051408.61
Participants: 2
Project status: CLOSED

Reducing aircraft noise emission is a priority for the European aviation sector, since both community and occupancy noises have significant environmental impact and constrain airport activities. In addition there is a strong interplay between low-noise technologies, fuel efficiency and air pollution. Computer simulations play a crucial role in the acoustic design of aircraft airframes and engines, by selecting novel concepts, optimizing final designs, and avoiding costly flight and static tests. But current computational tools are either unable or too inefficient to perform large acoustic simulations over the complete frequency range and taking into account the full geometrical and physical complexity. Further improvements in computational aero-acoustics will require novel numerical schemes, better integration with other engineering design tools, and also stronger alignment with the needs of private sector end-users. To achieve this, LMS and ISVR are leading this training and research program, together with Rolls-Royce as associated partner. The research activities will cover high-order methods, novel techniques for accurate geometry description, and extensions of the Boundary Element methods. These techniques will be used for the acoustic design of nacelles and Auxiliary Power Units (APU) which feature complex geometries and flow configurations, and for predicting installation effects (acoustic interaction between the engine and the wing) which currently requires vast computational resources. This research program is supported by a range of courses that combines the complementary expertise of the project partners (aero-acoustics, computational methods, CAD methods, aircraft noise). Such a combination of multi-disciplinary training activities is currently not available elsewhere, but is needed to develop researchers with the appropriate blend of expertise to support the future evolutions of aircraft noise predictions.
Resilience in East African Landscapes: Identifying critical thresholds and sustainable trajectories – past, present and future (REAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden,Sweden,United Kingdom,United Kingdom,Germany,Belgium,France
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 3968063.33
EU funding (EUR): 3968063.33
Participants: 7
Project status: CLOSED

The strong temporal dynamics of the East African landscape and natural-resource distributions have always encouraged people to innovate and adapt to changing conditions. However, increasing population growth, changes in patterns of land tenure, industrialization, weak systems of governance, and global climate change have exacerbated previously localized environmental problems such as soil erosion, depletion of water catchments, loss of forests and grazing land, falling soil fertility and biodiversity. Novel approaches for resolving these challenges are thus urgently needed. Based on the premise that the past is key to understanding the present and planning for the future, this ITN will establish a leading European training network devoted to combining state-of-the-art research methods to tap into under-appreciated knowledge of how indigenous peoples have previously adapted to East Africa’s intrinsically unstable climate and land/water resources. By bringing together ecologists, archaeologists, anthropologists, geographers, historians and agronomists the ITN will provide cross-disciplinary training to a new generation of researchers, enabling them to interpret data relating to past and present socio-cultural and ecological dynamics from across the environmental and social sciences and the humanities. Organized by researchers from seven European universities in partnership with Bayer East Africa and U&We, the ITN will co-operate closely with academic counterparts, private-sector stakeholders, NGOs and local communities in East Africa. It will highlight how detailed awareness of the complex history of human-environment interaction in East Africa is central to well-founded and ecologically sustainable resource management, thereby restore the important function of indigenous know-how crucial for devising development policies and climate-risk management for specific areas, and train a new generation of future ecosystem-service managers, policy makers and entrepreneurs.

Keywords: global sustainability,ecology,archaeology,anthropology,geography,history and agronomy,vegetation modelling,east africa
DIFFERENT (DIgital beam Forming For low-cost multi-static spacE-boRnE syNthetic aperTure radars) (DIFFERENT)

Framework: FP7 — Cooperation
Programme: Space
Destination: Cross-cutting activities
Action type: Collaborative project
Countries involved: Germany,Germany,Netherlands,Italy,United Kingdom,Poland
Call:  (FP7-SPACE-2013-1, 2013)
Start date: 2014-01-01
Duration (months): 56.0
Total project cost (EUR): 2620482.81
EU funding (EUR): 1984559.0
Participants: 7
Project status: CLOSED

DIFFERENT aims at building the foundation of a new generation of space-borne Synthetic Aperture Radars (SAR) with a significant reduction in cost, size, mass and power consumption, and enhanced performances with respect to systems currently available. The final product will be a compact, dual-band, dual-polarization radar with DBF capabilities. DIFFERENT will achieve these results setting up a consortium between SMEs and research institutions to develop and to exchange technologies and know how to improve competitiveness of SMEs. 1) DIFFERENT proposes advances towards space-borne radars building a low-cost, compact SAR by combining a) a new concept of multi-static dual-band (Ka/X) dual-polarization passive SAR having digital beamforming (DBF); b) the development of DBF BICMOS chip and of SiGe MMIC to enhance radar operations and to allow an unprecedented level of integration; c) the development of a dual-band (Ka/X) dual-polarized low-cost array antenna which will have a shared apertur; d) integration technologies that will make use of materials new to the space sector and that will ensure the high level of integration to reduce costs and weight of the overall payload. 2) DIFFERENT targets the stable integration of SMEs into the Earth Observation (EO) value chain by developing know how in the following key areas which are recognized as strategic for the future scientific and commercial missions a. SiGe BiCMOS integrated circuits b. Advanced integration techniques c. Digital Beam Forming 3) DIFFERENT will open to SMEs new possibilities in the entire space sector developing a distributed SAR space system fulfilling governmental and commercial needs. 4) The DIFFERENT consortium is tailored to sustain the involved SMEs towards the acquisition of a leading role in the EO value chain. SMEs central position in DIFFERENT is supported by a national space agency (DLR), by a research institute and technology provider (IHP) and by two academic partners (UNICAL / KENT)

Keywords: synthetic aperture radar sar digital beamforming multi-static radar high integration low cost compact size mixed signal silicon germanium
Creating an Agenda for Research ON Transportation sEcuity (CARONTE)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of infrastructures and utilities
Action type: Coordination and support actions
Countries involved: Germany,Austria,United Kingdom,Spain,Hungary,France,Spain,Slovakia,Germany,Belgium
Call:  (FP7-SEC-2013-1, 2013)
Start date: 2014-09-01
End date: 2016-02-29
Duration (months): 18.0
Total project cost (EUR): 1376461.94
EU funding (EUR): 1256869.53
Participants: 12
Project status: CLOSED

Easy, efficient, safe and secure transportation is a core factor for European growth, collaboration and employment and therefor an item in the Europe 2020 strategy. Land transportation has two main challenges concerning security: avoiding interrupts of transport itself to assure the flow of freight and passengers to guarantee supply of the population and avoiding that transportation modes themselves become a mean for attacks. The future research agenda for security in land transport which CARONTE will provide, focuses on core relevant gaps caused by emerging risks and will avoid doubling in research. For this CARONTE will provide answers to the question of what type of security related projects should be planned in the future, considering the current state of the art and existing research projects. It will cover all threats (including cyber-crime) and security aspects for all land transportation modes, respecting fundamental human rights and privacy. The step by step method includes analyzing the state of the art and emerging risks, identification of gaps, analyses and assessments of potential solutions and the research agenda. The CARONTE consortium consists of universities and research institutes, providing well experiences (research and consultancy) in transportation, logistics, infrastructure management and security. The partners are aware of practical needs and frames in land transport, and security as well as ethic, social and privacy aspects. As the partners come from neutral organizations, remaining neutrality concerning the project findings is guaranteed. Results which may mainly cover private interests are prohibited. This leads to a balanced and efficient research agenda. To ensure practical use and acceptance of the final recommendations, end-users (transportation companies, infrastructure managers, terminal operators, customs etc.) and the suppliers of security and transportation equipment will be integrated through a High Level Advisory Board.

Keywords: research agenda,land transport,security,emerging risks,state of the play,cyber-attacks,critical infrastructure,road,rail,inland waterway,human rights,privacy,economic growth,efficiency
Plant Tissue Cultures as New Production Platforms for Terpenoid Based Anti-Cancer Drugs (DRUGTISSUECULT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark,France
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2014-05-01
End date: 2018-04-30
Duration (months): 48.0
Total project cost (EUR): 586111.14
EU funding (EUR): 586111.14
Participants: 2
Project status: CLOSED

Plants produce a vast diversity of specialized and bioactive compounds. For thousands of years, mankind has used extracts from plants containing bioactive compounds as part of traditional herbal medicines. More recently anticancer properties of some bioactive compounds have been discovered and are now leads for new pharmaceutical drugs to combat cancers. In DrugTissueCult we focus on two bioactive compounds Thapsigargin and Withaferin A with anticancer properties. Both are of a pharmaceutical and economical value, but are difficult to obtain from their native source and very expensive to make through chemical synthesis. Thapsigargin, is a sesquiterpenoid found in Thapsia garganica plants and Withaferin A, is a triterpenoid found in Withania somnifera plants. The aim of DrugTissueCult is to generate plant tissue culture lines that produce very high amounts of Thapsigargin or Withaferin A. The industrial partner Alkion Biopharma has a patented technology that will be used to create a large collection of plant tissue cultures, which will be selected for significant production of Thapsigargin and Withaferin A. The academic partner, University of Copenhagen, Department of Plant and Environmental Sciences has an in-depth understanding of plant biochemistry, plants biosynthesis of specialized and bioactive compounds, and how to utilize this knowledge in biotechnological applications. Investigation of how Thapsigargin and Withaferin A are biosynthesized and identification of the genes behind, will lead to an overall understanding of terpenoid biosynthesis in plants. This will also facilitate the creation of tissue culture lines where selected genes are up-regulated to further enhance the production of Thapsigargin and Withaferin A. The complementary combination of the two partners provides the necessary knowledge and expertise to train two ESRs in a high impact research project using divergent training methods in industrial and academic settings.
Miniaturized Pressure Regulator (mPRS) (M-PRS)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: Austria,Germany,Germany,Spain,Liechtenstein,Switzerland
Call:  (FP7-SPACE-2013-1, 2013)
Start date: 2014-01-01
Duration (months): 42.0
Total project cost (EUR): 3479314.69
EU funding (EUR): 2474430.8
Participants: 6
Project status: CLOSED

The proposed project “mPRS” comprises the development of a miniaturized pressure regulation system with ultra low leakage, high reliability and an end-of-life venting capability (passivation) of tanks. Most of the space propulsion systems require a pressure regulation system (PRS) to have a constant inlet pressure of the propellant feed system. In the case of chemical propulsion systems the constant pressure is needed to repressurize the tanks as a prerequisite of a constant propellant flow. A PRS is also required for cold gas or electric propulsion systems. In this case the PRS provides the propellant flow either directly to the thrusters or to the inlet of subsequent flow control units. Common to all applications is the need, to reduce the tank pressure of several hundred bars at begin of mission, down to a low pressure between 2 and 20 bars to supply the thrusters. The PRS is a core element that is critical for mission success. Therefore a high reliability strategy with internal redundancies is mandatory. The proposed pressure regulator “mPRS” consists of three branches of three serial redundant valves in each branch. Two branches have a fixed configuration to form a redundant pressure regulator. The third branch can either be used to increase the redundancy or to allow a venting of the gas feeding system and the tanks at the end of the mission. The mPRS has the capability to control the pressure of the venting process. This allows advanced concepts to supply cold gas thrusters with the residual pressurized gas (still 20 bar at EOL) during a deorbit or graveyard maneuver.

Keywords: flow distribution pressure control unit propulsion components non-dependence
Socio-economic and Political Responses to Regional Polarisation in Central and Eastern Europe (REGPOL²)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Hungary,Slovakia,Romania,Estonia,Czechia
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 3165808.58
EU funding (EUR): 3165808.58
Participants: 8
Project status: CLOSED

The ITN RegPol² - Socio-economic and Political Responses to Regional Polarisation in Central and Eastern Europe centers on new patterns of regional disparities between metropolised core regions and the remaining parts of Central and Eastern European countries (CEE). Such spatial patterns have become a striking feature of the current settlement system of these countries and have lately fuelled concerns about further polarisation and the peripheralisation of non-metropolitan regions. Patterns of regional polarisation, however, do not remain restricted to CEE, but can be found throughout the European Union, albeit at different degrees. As such, there is an EU-wide high demand for professionals able to deal with the spatial implications of these issues. This holds true all the more so as balancing spatial development has been a major goal of European Regional Policy. Against this background, RegPol² trains 16 young researchers for careers in academia, public administration, NGOs and the private sector. Research training is organised in 3 work packages which comprise individual, albeit strongly interconnected research projects. Each project includes intersectoral secondments providing trainees with occupational skills while at the same time strengthening the interface between academia and the private sector. Local trainings will be supplemented by network-wide events enabling strong collaboration between the partners. Training includes transferable skills as well as theoretical and methodological units. The network draws on expertise from academia and private sector specialists from 7 different countries and 8 scientific disciplines used to working in interdisciplinary and multi-national contexts. Next to new training capacities at European level and an increased employability of ITN fellows, the project aims at improving regional policy instruments by raising capacities of politicians, public and private sector policy makers related to issues of regional polarisation.

Keywords: regional polarisation,core-periphery relations,regional disparities,regional policy,regional governance,social and economic innovation processes