Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-energy cosmic neutrinos astronomy using a Mediterranean undersea telescope (NEUTEL-APC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-06-01
End date: 2011-05-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The observation of high-energy cosmic neutrinos, produced in distant astrophysical accelerators (and possibly by means of more exotic processes as well), has turned into one of the major challenges of today’s astroparticle physics, motivated by the possibility to open a new observational window on the distant Universe. The present project is a contribution to the experimental effort being carried by the european scientific community to build a large-scale undersea neutrino telescope in the Mediterranean. The efficiency of the data collection and analysis will be assessed through the study of the performance of the prototype instrument ANTARES (currently being deployed offshore near Toulon, France), in order to optimize the detection potential of the telescope, with a particular attention to neutrino point sources searches. The sensitivity of the telescope to ultraenergetic neutrinos, as well as to possible signatures of new physics, will also be investigated. A technical contribution will be dedicated to the characterization of the optical modules ageing in conditions of irradiation (e.g. bursts of bioluminescence) similar to those encountered in the deep sea. The interpretation of the first data on the basis of up-to-date astrophysical and cosmological models will provide important benchmarks for the subsequent building of a cubic-kilometer-sized detector in the Mediterranean, now in design study in the KM3Net collaboration.

Keywords: cosmic neutrino detection,high energy physics,astrophysics,particle physics
Structural studies on protein recognition and regulation (HDAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-01
End date: 2011-02-28
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

With this application, funding is applied for a new project to be started at the Department of Biochemistry, University of Oulu in 2008. The focus of the project will be on structural aspects of protein recognition and regulatory events. To start with, the project will concentrate on selected histone deacetylases and profilins as well as members of the formin family of proteins. X-ray crystallography will be used as the main tool, but the structural work will be complemented by other biochemical and biophysical characterization. Histone deacetylases (HDAC) are, due to their essential role in transcriptional activity as well as many other cellular processes, among the most interesting targets for pharmaceutical research. At present, there is very little information on the structure, specificity, and regulation of various HDACs. This project will focus on structural studies on selected HDACs - to start with HDAC-6, -10, and -11 - and their binding partners. HDAC-6 is a tubulin deacetylase, whereas the biological functions of HDAC-10 and -11 are not very well characterized. In addition to the HDAC catalytic domains, structures of the regulatory domains and binding partners will be pursued. Also inhibitors and substrate-peptides will be used for co-crystallization experiments. Formins are large multi-domain proteins that are involved in the formation of actin filaments by binding to the growing end of actin filaments and e.g. profilins. Diaphanous-related formins are autoregulated, but many other formin family members lack the autoregulatory domains. Many questions remain to be answered concerning the complex regulation of formins and the specificity of different formins with respect to different profilins. Recently, formins have been suggested to affect also microtubule dynamics by co-operating with HDAC-6. The biological significance of this finding remains to be confirmed, but this opens up a new intriguing path to the HDAC and formin field.

Keywords: structural biology,cell biology,molecular biology,medical sciences
Unraveling the biosynthesis of fatty acid-based lipid polymers in plants (BIOLIPOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-05-01
End date: 2012-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cutin and suberin are plant-specific extracellular lipid polymers that are involved in critical water and pathogen barrier functions at the interface between plants and their environment. The biosynthesis of these glycerol- and fatty acid-based polymers remains largely unknown. Understanding how plant cells oxidize, activate, transfer and polymerize acyl chains in the pathway of biosynthesis of cutin and suberin would be helpful to manipulate the composition of plant hydrophobic barriers and obtain crops with higher resistance to pathogens or desiccation. In addition, the reactions of lipid polyester biosynthesis involving oxidized fatty acids are likely to be highly relevant to the bottlenecks that are currently limiting the production in plants of high amounts of omega-hydroxy fatty acids and dicarboxylic acids, which are biomolecules with potential to replace petroleum for the synthesis of polymers and specialty chemicals. The applicant and his colleagues at Michigan State University have identified the first mutant affected in suberin synthesis, characterized a family of glycerol acyltransferases involved in polyester biosynthesis in the model plant Arabidopsis thaliana and shown that these acyltransferases are key partners of P450 fatty acid oxidases for the production of oxidized fatty acids in plant cuticles. In order to further understand the acyl activation, acyl oxidation and acyltransfer reactions required for the biosynthesis of lipid polymers in plants and to identify more players in this pathway, the applicant proposes to: 1) Pursue a knock-out/overexpression approach in Arabidopsis on a larger scale. 2) Co-overexpress various combinations of these Arabidopsis enzymes in yeast in an attempt to characterize their activity and determine the minimal number of genes required to produce polyacylglycerols containing hydroxy-fatty acids and/or dicarboxylic acids. 3) Determine the subcellular location of the enzymes identified.

Keywords: plant metabolism,cutin,suberin,epidermis,lipid polymers,polyesters,hydroxy-fatty acids,dicarboxylic acids,genetic engineering,acyltransferases,fatty acid oxidases
Peroxisome proliferator-activated receptor gamma in inflammation (PPARS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-01
End date: 2011-02-28
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily whose ligands are liophilic compounds. Early studies on PPARs action revealed their role in diverse aspects in development and homeostasis. Despite the substantial research effort targeting PPARs role in metabolism including lipid metabolism, glucose homeostasis and adipogenesis the exact mechanisms by which PPARs regulate metabolic processes are poorly understood. Yet another facet of PPARs action is that there is an accumulating body of evidence showing that these transcription factors are active in immune cells and participate in the regulation of immune response. Therefore, PPARs represent a unique class of transcription factors that links metabolism to immunoregulation. In spite of the in vitro evidence implicating PPARγ in immunoregulation, in vivo studies on the role of PPARγ in immune response have been lacking. It is also poorly understood how the transcription events in metabolism connect to the transcriptional regulation of cell differentation and immunoregulation. Current proposal aims to deliver two objectives. The in vivo role of PPARgamma in immunoregulation will be investigated in infection studies in which mouse strains with macrophage and dendritic cell specific conditional PPARγ deletion will be infected with pathogens that trigger TH1 or TH2 type immune responses. Our second objective is to understand better the mechanism of regulatory events directed by PPARγ. We will test our hypothesis that a section of PPARγ signalling in the regulation of inflammation occurs via the action of microRNAs. The successful completion of our proposal will define the in vivo importance of PPARγ in immunoregulation and potentially unveil another layer in the mode of actions of PPARγ

Keywords: nuclear receptor signalling,metabolism,inflammation,macrophages,dendritic cells,in vivo models of ppar? functions,mirna,alternative macrophage activation
Developing Europe's Rural Regions in the Era of Globalization: An Interpretative Model for Better Anticipating and Responding to Challenges for Regional Development in an Evolving International Context (DERREG)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Combining economic, social and environmental objectives in a European perspective
Action type: Collaborative project
Countries involved: United Kingdom,Germany,Czechia,Ireland,Sweden,Germany,Slovenia,Netherlands
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 1916222.0
EU funding (EUR): 1499084.0
Participants: 9
Project status: CLOSED

Globalization is one of the key challenges facing rural regions in Europe, bringing significant social, economic, cultural and political changes. Current studies on the impact of globalization on rural regions tend to focus on specific sectors or processes or localities. The absence of an overarching integrative analysis has resulted in the inability of regional development strategies to cope with these challenges. The objective of the DERREG project is to produce an interpretative model that will enable regional development actors to better anticipate and respond to the key challenges for disadvantaged regions arising from globalization. In doing so, it will expand scientific knowledge and understanding, inform policy development, and identify examples of best practice. The project is innovative in adopting an integrative approach that synthesises research across four key themes and nine case study regions in different types of rural regions to produce an overarching analysis of the impact of globalization on rural Europe. The research will involve both qualitative and quantitative data collection and analysis. It will develop new methods in areas such as business network analysis. A further innovation is the linking of the scientific analysis with practical application through the development of an interpretative model. The consortium comprises 9 partners with expertise in rural and regional research, focusing on Eastern Europe. The consortium has been assembled to provide an appropriate combination of expertise in the areas examined in the project, including rural businesses, migration, sustainable development, capacity-building and gender. The proposed research will enable policy makers and other stakeholders involved in regional development to better anticipate and respond to the challenges of globalization. It will support initiatives to increase the capacity of rural businesses to engage with new opportunities and to enhance social cohesion.

Keywords: globalization,rural regions,disadvantaged regions,central and eastern europe,local embeddedness,migration,eco-economy,capacity building,interpretative model,best practice database
Innovation Futures in Europe: A Foresight Exercise on emerging Patterns of Innovation. Visions, Scenarios and Implications for Policy and Practice (INFU)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Foresight activities
Action type: Collaborative project
Countries involved: Austria,Germany,Belgium,Germany
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2009-06-01
End date: 2012-01-31
Duration (months): 32.0
Total project cost (EUR): 598082.0
EU funding (EUR): 482889.0
Participants: 4
Project status: CLOSED

The INFU Foresight project will develop plausible and relevant long-term scenarios of future innovation landscapes in order to orient long-term strategy building for policy and other innovation actors. The scenarios will outline how future actors may collaborate in new configurations and with new approaches to transform knowledge into products and services within different socio-economic frameworks. To generate this anticipatory intelligence INFU is implementing a progressive explorative dialogue with key stakeholders and experts using advanced creativity methods to foster thinking beyond established pathways and up-to-date prospective methods to structure the debate and ensure rigour of analysis. Particular emphasis is placed on optimising the knowledge flow through tailored and vivid formatting of outcomes for audiences in and outside the project. The INFU futures dialogue departs from an identification of emerging signals of change in current innovation patterns and progresses with increasing integration of diverse perspectives and knowledge sources towards consolidated innovation futures scripts. These bottom-up visions are then confronted with different possible socio-economic framework conditions and global megatrends to finally synthesise consistent scenarios that are integrating micro, meso and macro elements of possible innovation futures with particular emphasis on the changes in nature and content of research. The explorative analysis will be complemented with value-related debate on the desirability of different innovation futures based on an assessment of the scenario implications for key societal challenges such as sustainability. Options for policy strategies to prepare for the identified changes in innovation patterns are derived together with key policy actors. The INFU consortium comprises strong complementary competencies in Foresight, strategic support to policy and industry and academic innovation research.

Keywords: foresight,innovation,scenarios,innovation systems,user innovation,open innovation
Meeting the challenges of economic uncertainty and sustainability through employment, industrial relations, social and environmental policies in European countries (GUSTO)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Combining economic, social and environmental objectives in a European perspective
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,Spain,France,Hungary,Denmark,Netherlands,Italy,Germany,United Kingdom,Czechia,Belgium,Canada
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2009-03-01
End date: 2012-07-31
Duration (months): 41.0
Total project cost (EUR): 2265112.2
EU funding (EUR): 1496829.0
Participants: 13
Project status: CLOSED

Coping with economic uncertainty while seeking security is a central dilemma of public policy in a globalising economy. A complex set of deals and conflicts are involved in the process of distributing the gains and the burdens of that uncertainty, and various forms of employment contracts and labour and social policies express their outcome. This project is concerned with the study of that process and its implications for societal models. In the course of conflict a number of different institutions engage in new practices; and there is a new diversity of employment forms and tenures. Social policy becomes increasingly integrated with employment and industrial relations practices, while both the sustainability of the institutions themselves and their impact on the natural environment require consideration. Challenges are also presented by the different forms of governance at work in the various policy fields. The crisis of the Keynesian model was often seen as a crisis for associational governance (or neo-corporatism), and an advance for reliance on market governance (usually assisted by strong elements of government intervention). Since then, policy-making by individual large corporations often seems to be replacing associational governance as well as government policy-making in fields of employment categories and rights, pay determination, and the determination of pensions. However, the public goods issues raised by uncertainty and environmental damage bring again into question the adequacy of governance by the market and individual firms. We should expect to find radical changes in the societal models that we have become accustomed to using in the analysis of social policy. There is a search for new modes of governance, or new combinations of old ones.

Keywords: uncertainty,flexicurity,governance,employment transitions,pensions,immigration,sustainability
Semantically Enhanced Resilient and Secure Critical Infrastructure Services (SERSCIS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Austria,Austria,Spain,Greece
Call:  (FP7-ICT-SEC-2007-1, 2007)
Start date: 2008-10-01
End date: 2012-11-30
Duration (months): 50.0
Total project cost (EUR): 2929554.0
EU funding (EUR): 2000000.0
Participants: 6
Project status: CLOSED

The goal of SERSCIS is to develop adaptive service-oriented technologies for creating, monitoring and managing secure, resilient and highly available information systems underpinning critical infrastructures, so they can survive faults, mismanagement and cyber-attack, and automatically adapt to dynamically changing requirements arising from the direct impact on the critical infrastructure from natural events, accidents and malicious attacks. The project will use a service-oriented architecture to make interconnected of ICT systems more manageable, allowing dynamic adaptation to manage changing situations, and counter the risk amplification effect of interconnectedness. To control the resulting ICT components, the project will develop: • tools and ontology for modelling of critical infrastructure including ICT components, to capture their requirements, behaviour and compositional nature; • system dependability metrics and agreements, and dynamic governance mechanisms, including dynamic trust management; • system composition mechanisms allowing dynamic discovery and interconnection of component services; • decision support tools that exploit underlying semantic models to provide situational awareness of system status and threats. Semantic system models will enable a unified approach across all these developments: semantic requirements models lead to reliability statements in service dependability agreements, which can be used by adaptive composition mechanisms, allowing management of larger composed systems to meet their requirements. These innovations will be validated in two information-intensive critical transport infrastructures, both of which require interconnected ICT: air traffic flow control and airport airside process optimisation through collaborative decision making in airports, and inter-modal port community operations. Results will be widely disseminated to critical infrastructure end users, and to relevant regulatory and standard bodies.

Keywords: critical infrastructure,system modelling,dynamic trust,dynamic management,decision support
Digital and Innovative Technologies for Security and Efficiency of First Responders operation (DITSEF)

Framework: FP7 — Cooperation
Programme: Security
Destination: Security systems integration, interconnectivity and Interoperability
Action type: Collaborative project
Countries involved: France,Netherlands,France,Greece,France,Italy,Czechia,Bulgaria
Call:  (FP7-ICT-SEC-2007-1, 2007)
Start date: 2010-01-01
End date: 2013-03-31
Duration (months): 39.0
Total project cost (EUR): 4180384.01
EU funding (EUR): 2798517.5
Participants: 11
Project status: CLOSED

The main problem of First Responders (FR) (fire fighters, police, etc...) in case of crisis at critical infrastructures are the loss of communication and location and the lack of information about the environment (temperature, hazardous gases,etc.). Therefore, during the intervention, there is a gap between the First responders' situation (positioning, health,etc) and the overall view of at their mobile headquater. DITSEF aims at increasing the effectiveness and safety of First Responders by optimal information gathering and sharing with their higher command levels. DITSEF will provide: - Self organising robust ad-hoc communications where the existing infrastructure may be compromised, allowing communication between the First Responders and between them and their command level. - Accurate novel 3D positioning in indoor environments. - Sensors that offer a reliable overview of the situation and of the potential threats (explosives, chemicals, fire, etc.) - Enhanced vision for the FR in visually -impaired conditions, trough ingenious and unprecented HMIs consisting of sensors-based visual elements, showing spatial features and thermal imagery overlaid on the direct perception of the First Responder. The operational value of the integrated solution will be demonstrated through users defined scenarios in a real operational environment. it will incorporate end-users from both the Critical Infrastructures' domain and the First Responders' domain. Five dedicated workshops will allow the collection of users requirements, operational scenarios and allow the cross-fertilisation of information on operations and procedures of players from different states and domains; they will create awareness on project results and prepare their take-up. Attention will be paid to standardisation issues. DITSEF will be implemented by a strong partnership of 10 members, including SMEs, large industries, research centres, technology providers, system integrators and end-users.

Keywords: robust self-organising communications infrastructures,ingenious and unprecendeted hmis,novel 3d positioning,sensors detection,end-users involvement,demonstration in critical infrastructure