Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gaming Ecosystem as a Multilayered Security Threat (GEMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Ireland,United Kingdom,Greece,Sweden,Spain,Belgium,Kosovo,Germany
Call: Enhanced fight against the abuse of online gaming culture by extremists (HORIZON-CL3-2022-FCT-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2864352.5
EU funding (EUR): 2864352.5
Participants: 10
Project status: SIGNED

There is widespread agreement across police authorities, policy makers and the academic community that the video gaming ecosystem plays a substantial role in the process of radicalization. However as yet there is no compelling evidence base to understand how the process takes place, or the best measures to prevent the radicalization process. Games as a Multi-layered Security Threat (GEMS) is an interdisciplinary, mixed-method and cross-sectoral project bringing together academic researchers, AI specialists, policy experts and a range of police authorities from across Europe in order to address this challenge. Co-creation of knowledge with a comprehensive end-user engagement is the fundamental principle of GEMS. The main aims of GEMS are: 1) to contribute to a scientific advancement of the field of radicalisation and violent extremism by developing a new academic field of Sociology of Gaming and Radicalisation; 2) to provide EPAs with a novel Training Curriculum and an innovative tool, the Watchtower (a future-proof AI platform trained to recognise and prevent the spread of extremist content and recruitment in the online gaming space); 3) to create a new cross-sectoral collaborative network dedicated to countering extremist presence in the gaming ecosystem – European Networks Against Gaming-Related Extremism (ENgaGE); and 4) to develop an effective Citizens Awareness Campaign and evidence-based Policy Solutions which will greatly improve high level decision making, empower citizens and enhance youth protection. These aims will significantly contribute to the fight against the rapid spread of extremism in the online gaming spaces and lead to a secure cyberspace.

Keywords: gaming youth protection sociology
LightCure - Light for double specificity and efficacy without burden (LightCure)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Austria,United States,United Kingdom,Portugal
Call: Development of new effective therapies for rare diseases (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 8182057.13
EU funding (EUR): 8182057.13
Participants: 12
Project status: SIGNED

Congenital hyperinsulinism (CHI) is a group of rare diseases of newborns and infants with functionally defective nonneoplastic beta-cells that cause hypoglycemia and severe morbidity through oversecretion of insulin. CHI is a major cause of hypoglycemic brain injury with intellectual disability, epilepsy and cerebral palsy. As no registered causal therapy exists, management of CHI aims at increasing blood glucose levels causing severe side effects in all patients while life-threatening frequent hypoglycaemias remain. Removal of hyperfunctioning beta cells by pancreatectomy leads to insulin dependent diabetes mellitus (IDDM) and maldigestion of food, changing one disease for another with severe secondary morbidity. Management of CHI is choosing between evils and symptomatic management is partially effective in only some sub-types. CHI also represents a major burden for families, because of disability but also as a result of continuous monitoring and correction of glucose levels for many years, requiring permanent alertness. Health problems and economic decline occur in most parents. A normal life is not feasible for families with babies with CHI. LightCure consortium partners have demonstrated the feasibility of selectively targeting beta cells using exendin 4 (EX) labelled with a photosensitizer (700DX) specifically binding to beta cells. This photosensitizer can be activated by light of a certain wavelength and will produce radical oxygen species leading to cell damage, a principle called targeted photodynamic therapy (tPDT). In this project we will build on existing cutting-edge technology exclusively available to the consortium partners and perform human proof of concept studies demonstrating safety and efficacy of tPDT with EX700DX. We will deliver the proof-of-concept that after injection of EX700DX, minimally invasive tPDT leads to normalization of blood glucose levels avoiding morbidity, enabling a normal life for babies with CHI and their families.

Keywords: minimally invasive therapy,companion diagnostics,positron emission tomography,photodynamic therapy
Identification of novel diagnostic, predictive and therapeutic strategies in chronic kidney disease (TargetCKD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1999063.0
EU funding (EUR): 1999063.0
Participants: 1
Project status: SIGNED

Chronic Kidney Disease (CKD) represents an important medical, social and economic burden with high morbidity and mortality. The prevalence of CKD has reached >10% in the developed world, and CKD globally accounts for more years lived with disability than all neoplasms combined. Therapeutic strategies to treat CKD or tools for risk stratification of patients are limited and the field has produced the fewest translational randomized clinical trials in medicine while diagnosis is still based on invasive tissue biopsies. TargetCKD aims to establish a holistic understanding of cellular and molecular mechanisms that drive disease to develop novel diagnostic, predictive and therapeutic options. Concrete objectives are: (1) the development of a platform for identification of novel predictive markers and therapeutic targets in kidney biopsies; (2) the identification of conserved spatio-temporal mechanisms and cellular cross-talk events driving CKD; (3) the validation of mechanisms and therapeutic targets in human 3D organoid systems and development of therapeutics and (4) the development of a noninvasive diagnostic platform from urine. TargetCKD will utilize a broad interdisciplinary expertise with various novel single cell and spatial genomic and computational technologies combined with transgenic mouse models and cutting-edge in vitro platforms. The integration of all these technologies in clinical relevant specimen with follow up data and large independent validation cohorts will allow TargetCKD to radically transform nephrology towards a better understanding of kidney diseases, development of novel diagnostics and risk stratification tools for patient allocation and clinical testing as well as urgently needed therapeutics for patients suffering from CKD. The passion that drives this project results from a simple emerging hypothesis: It is possible to predict CKD and develop therapeutics by an in-depth systems approach utilizing emerging genomic technologies.

Keywords: chronic kidney disease
Cinephilia, Urban Spaces and Affective Memories: Mapping cinephilic places in 1950s-1980s Lisbon (CineTopos)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

CineTopos explores the intersection of cinephilia and topophilia. The first refers to the love for cinema, a love composed of moments, rituals, and artifacts; while the second refers to the ‘love of place’, the emotional connection that individuals have with specific places. In effect, the concept of ‘topos’ includes both a physical and a mental space. I argue that both concepts can be connected, and I will address cinephilia as a ‘site-specific’ phenomenon, deeply connected to a specific location and geography. My approach will contribute to an underexplored area, as current discourse generally focuses on the relationship between cinema and urbanism. Unlike studies that examine how films depict cities or how cities are shaped by the evolution of movie theatres, my research will delve into the social spaces linked to cinephilia that extend beyond cinemas or film clubs. Indeed, cinephilia was shaped by cinephilic places par excellence - cinemas, ciné-clubs, video rental stores – but also 'cinephilic para-spaces' – such as cafés and restaurants where cinema was discussed, and neighborhoods frequented by cinephiles. As a case study, I will focus on Lisbon from the 1950s to the 1980s. Lisbon is a peripheral and often overlooked capital within Western European film studies. However, within Lisbon, one can find many ‘cinephilias’, with their variations, communities and subcultures. Distinctions can be made based on social class and wealth, as well as on cinematic ‘schools of thought’. I aim to map the spaces and places that were significant for cinephile and film culture over time (1950-1980), including key social and political changes like the Carnation Revolution, and to identify which elements persist in contemporary Lisbon. This topic lends itself not only to academic dissemination and knowledge transfer, but it can also serve as project creating community involvement and activating intergenerational cultural memory in relation to cinephilic spaces.

Keywords: film culture film history cinephilia spatial theory urban identities
Fostering food system transformation by integrating heterogeneous perspectives in knowledge and innovation within the ERA (FOSTER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Hungary,Serbia,Spain,Netherlands,United Kingdom,Portugal
Call: Furthering food systems science and federating researchers across the European Research Area (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 5063631.25
EU funding (EUR): 5063631.25
Participants: 19
Project status: SIGNED

The vision of FOSTER is to build a foundation from which a new Knowledge and Innovation System (KIS) for Europe’s food system can emerge. The current structure is insufficient to address the emerging challenges of nourishing people in a healthy and sustainable way. Key objective is to gain insights into how it can be built to be more inclusive and better governed. FOSTER shall help to transform Europe’s food system outcomes and will achieve this by: - building a FOSTER Platform including food system-state of the art knowledge, foresight by semi-automated Horizon scanning, trend and threats-analysis and new multi-dimensional scenarios of EU food systems to 2040; - implementing the FOSTER Academy -including 4 Summer Schools- for integrating food system-related disciplines and citizen science to enhance food system understanding across the ERA; - initiating and assessing a co-creation and co-learning process within six national resp. regional Citizen Driven Initiatives (CDIs), in which new knowledge, strategies and Action Research Agendas are gained; - scaling out and deep CDIs solutions and approaches to other territorial contexts; - studying different R&I mechanisms of policy support for mission-oriented R&I policy for food systems transformation, and analysing and ground-proofing them in each CDI; - strengthening science-policy interfaces by co-learning processes with external experts and developing recommendations for food systems R&I policies tailored to different geographies and sectors; - identifying the trigger points to help ‘unlock’ system lock-ins and support further dynamics towards system transformation; - and applying reflective monitoring on all FOSTER’s co-learning activities to develop insights into how the KIS can be broadened from an agricultural-KIS to a food system-KIS. To inspire adoption of FOSTER learnings, over 20 workshops and a final conference will be conducted; scientific position papers and policy briefs will be widely communicated.

Keywords: co creation,co learning
Algebraic Formula Lower Bounds and Applications (ALBA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1869055.0
EU funding (EUR): 1869055.0
Participants: 1
Project status: SIGNED

Does efficient verification imply efficient search? Can randomness provide massive speed-ups in computation? These are fundamental questions in theoretical computer science, known as P vs. NP and P vs. BPP respectively. Progress on these questions requires us to to show that certain computational problems are inherently intractable, i.e. do not admit efficient solutions. An important, and concrete, approach to such questions is to understand the complexity of algebraic problems such as the Determinant and the Permanent, in algebraic models of computation. The aim of this project is to tackle these questions head on. Recent results of the PI and his collaborators have made progress on these problems by resolving a three-decade old open question. These results show intractability for algebraic models of bounded depth, which is a step towards P vs. NP. As a consequence, they also imply the first sub-exponential time deterministic algorithms for the important Polynomial Identity Testing (PIT) problem in these settings, which is progress towards P vs. BPP. However, this barely scratches the surface of what we want to achieve. The aim of this project is to push beyond these state-of-the-art results in many directions. The principal goal is to prove the first lower bounds for algebraic formulas, which would be a huge breakthrough. Further, we want to improve our recently obtained lower bounds in order to devise faster PIT algorithms. We also want to show lower bounds over finite fields, and to explore the applications of such work in related areas such as algebraic proof complexity and algorithm design. The recent results point out a new way of exploiting structural and algebraic techniques to prove lower bounds. The aim is to develop and systematically investigate these techniques, incorporating methods from related fields of mathematics such as the theory of symmetric functions and representation theory, to accomplish these goals.

Keywords: circuit complexity,arithmetic circuits,permanent vs determinant,lower bounds,polynomial identity testing,derandomization
European Thematic Network for unlocking the full potential of Operational Groups on alternative weed control (Oper8)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Greece,Spain,Italy,Latvia,United Kingdom,Sweden,France
Call: Broaden EIP Operational Group outcomes across borders by means of thematic networks, compiling and sharing knowledge ready for practice (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1615800.0
EU funding (EUR): 1615800.0
Participants: 10
Project status: SIGNED

Oper8 will set-up a self-sustainable, multi-actor, EU-wide Thematic Network to support and promote solutions for non-chemical weed control by building upon the knowledge and outcomes of 8 Operational Groups 7 countries, and stimulate knowledge exchange among all relevant actors and stakeholders. With the ambition to achieve a high impact and improve the sustainability of the European agricultural sector, the synthesis of partner OGs is based on their expertise, geographical location, novelty of solutions, as well as the established connections with the AKIS actors. Special emphasis has been placed on collaboration schemes among these OGs that progress at a different pace providing the opportunity to learn from the ‘early birds’, which will bring hands-on experience. The project will follow a multi-actor approach, implement a bottom up and top down model and build upon co-creation & cross fertilisation activities to help farmers access up-to-date knowledge, tools and techniques, applicable to specific conditions and needs.To this end, Oper8 will: (i) establish a stakeholder engagement processes to assemble the 7 National Networks (NNs); (ii) capture the drivers, barriers, and root causes of lack of non-chemical weed control adoption as part of a bottom-up approach; (iii) establish cross-fertilisation activities within and between the NNs to co-create, showcase, and evaluate non-chemical weed control methods; and (iv) deploy knowledge transfer tools and techniques (workshops, demo farms, CAP Measures) to adapt and scale up alternative weed control solutions and ensure their diffusion across EU. A series of actions (e.g., demonstration activities, policy recommendations and training sessions) for integrating project results into the CAP National strategic plans will be implemented, strengthening the AKIS and, ultimately, paving the way towards a transition to a sustainable agriculture in adherence to the Green Deal and its Farm to Fork strategy.

Keywords: operational group,non chemical weed control,thematic network
Training network for tracking and controlling therapeutic immune cells in cancer (T-RAFIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Denmark,Netherlands,France,Norway,Austria,Switzerland,United Kingdom,Italy
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 4242270.86
EU funding (EUR): 4130611.2
Participants: 28
Project status: SIGNED

Cancer immunotherapies have been established in a growing number of clinical indications and the pace of development is massively accelerating. Currently over 6.000 clinical trials are investigating immune-related treatments in oncology especially in combinations. It includes both adoptive cellular therapies and immune modulating treatments like immune check point blockade. In contrast, the understanding of how such therapies mediate their mode of action is still mostly poorly understood. In particular, the role of distribution and relocation of immune cells after therapeutic interventions remains unknown. This is surprising, as immune cell interactions are a hallmark of therapeutic immune responses. T-RAFIC will enhance understanding of immune cell trafficking under therapeutic influence. It will open new paths and avenues to treatments, boost their efficacy and help prioritizing the plethora of immune therapeutic combinations. In the past, detailed analysis of cellular distributions was facing technical barriers. Advances in technologies, now permit tracking and visualization of cells in vitro and in vivo at an unprecedented resolution, allowing for the first time studies on immune cells under therapeutic influence. This emerging field of research has enormous potential and key importance for next generation of researchers in oncology and beyond. However, experts in this field are missing and this threats European research, development and medicine. Therefore, T-RAFIC joins forces of 19 academic and three industrial partners from nine European countries to conduct an innovative and interdisciplinary approach combining cell imaging with bioinformatics, cell engineering and clinician expertise. The network bundles recognised expertise in cancer immunotherapies, empowering European research and innovation and ensuring a sustainable cooperation in science and training.