Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
C-NEWTRAL: smart CompreheNsive training to mainstrEam neW approaches for climaTe-neutRal cities through citizen engAgement and decision-making support for innovative governance and integrated pLanning (C-NEWTRAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland,Italy,Germany,Netherlands,Denmark,Romania,Finland,Hungary,Belgium,Spain,United Kingdom,Poland,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2715796.8
EU funding (EUR): 2715796.8
Participants: 27
Project status: SIGNED

Achieving climate-neutral cities is an EU priority, yet faces many challenges because of the complex urban activities, and the vast range of stakeholders involved. The European Commission has identified ‘participative city governance’ and ‘integrated urban planning’ as key enablers for driving climate-neutral cities forward. Cities require enhanced capacity and ongoing support for implementation of climate-neutral solutions and assessment of how they may impact different sections of society. There is however, a lack of highly-skilled, highly-trained interdisciplinary researchers and professionals for this task, which C-NEWTRAL aims to address. C-NEWTRAL is underpinned by five key thematics (Urban Nature, Urban Mobility, Built Form, Energy, Circularity), which are integrated through two cross-scale research dimensions, linked to drivers identified by the EU: I. Citizen Engagement & Public Participation and II. City Governance & Decision-Making. This provides a framework for individual research projects examining participation and decision-making for integrating nature-based solutions in urban regeneration, active/ green/ just mobility transitions, social acceptance of energy performance standards in buildings/ neighbourhoods/ social housing, hydrosocial/ circular/ digital approaches in urban water management, and nexuses among these. Each researcher will be trained in advanced participative methods and use of governance & planning tools, supported by digital technologies - recognised by the EU as a priority, but still under-developed within city planning processes. Researchers will be exposed to secondments in local authorities, NGOs or industry. The program will provide a dynamic, intellectually-challenging, interdisciplinary training environment attracting the best international graduate candidates and fosters an enthusiastic and innovative community of researchers - effectively placed to advise on cross-sectoral strategies for achieving climate-neutral cities.

Keywords: climate neutral city public participation citizen engagement city governance decision making social science and humanities methods integrated planning
Understanding Metabolic Activation of Dendritic Cells in Non-Alcoholic Fatty Liver Disease (Metabo3DC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2406250.0
EU funding (EUR): 2406250.0
Participants: 2
Project status: SIGNED

Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with no approved treatments, and dire outcomes for patients. The pathogenesis of NAFLD is clearly linked to metabolic alterations, and is primarily characterized by excessive hepatic triglyceride content. Over time, metabolic dysfunction induces hepatic inflammation through mechanisms that remain poorly understood. This advanced disease stage, called non-alcoholic steatohepatitis (NASH), significantly raises the risk of hepatocellular carcinoma, cardiovascular disease and type-2 diabetes. My recent work has helped demonstrate that: 1) changes in conventional dendritic cell (cDC) populations in liver are closely associated with the development and the resolution of NASH in humans, and 2) extracellular metabolites can modulate cDC cytokine production and responses by rewiring their intracellular metabolic programs. Together, these studies indicate that alterations of the local hepatic metabolite environment could affect cDC function and thereby drive NASH pathogenesis. cDCs coordinate innate and adaptative immunity through cytokine secretion and antigen presentation. However, their role in NAFLD pathophysiology not well defined. In this ambitious multidisciplinary project, my objective is to systematically dissect the immuno-metabolic programs and functions of hepatic cDC during NASH progression and regression. First, we will identify disease-associated cDC subpopulations and their intracellular metabolic programs. We will then determine whether these cDC subtypes associate with specific local metabolic microenvironments in the liver in relation to histological features of NAFLD. Finally, we will determine how metabolic manipulation of cDC affects their immune function in the context of NASH. The present proposal has the potential to radically transform our understanding of NASH pathophysiology by delineating the specific links between metabolic dysfunction and innate immunity in liver disease.

Keywords: immunometabolism
Precise X-Y-Z Readout with a micro-Magnetometer Inverted-pyramid Design (PYRAMID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Chip-scale magnetometers come in several flavors, the most common being silicon Hall-effect plates that integrate easily with electronics. However, these devices only detect 1D fields, are asymmetric between X-Y and Z directions, and cannot work in extreme temperatures. My goal is to leverage my expertise in micromachining and wide-bandgap semiconductor Hall-plates to realize magnetometers with a unique "3D" microstructure that uses 10% of the space of existing "3x1D" sensors, and is 3-10x more accurate. This enables new products for 3D navigation in autonomous microsystems such as biomedical implants, power monitoring, and nanosatellites. This proposal will involve the development of the inverted pyramid device through crystallographic etching of <100> CMOS silicon to expose the <111> crystal plane at 54.7°. This enables higher angular accuracy and avoids fabrication misalignment or packaging errors. The <111> also supports direct GaN and other 3D Material integration with CMOS chips. In parallel, the host group, the Electronics Instrumentation(EI) laboratory at TU Delft, will develop the CMOS integrated circuit for front-end amplification and switching scheme of the sensor to detect all three components of the field from a singular device. The EI lab is top-ranked in circuits design and complements my sensor development activities seamlessly. The final year of the project will focus on testing these chips packaged together and development of a integrated single chip with both sensor and circuit to reveal improved performance with the use of graphene as the device layer. This project will open up future work with (ultra) wide-bandgap material integration using GaN and/or Diamond to enable extreme-environment navigation sensors with exotic applications in high temperature environments. The project will improve my career prospects as a tenure-track professor with training in circuits, teaching and tenure-track professional development at TU Delft.

Keywords: hall effect sensor,magnetic sensing,microelectromechanical systems,cmos integrated circuits
Innovative chemical reaction and photocatalyst design methods for sustainable CO2 reduction (PHOCAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

The photocatalytic conversion of CO2 into valuable chemicals such as CO is a promising solution to mitigate both the health and environmental impact from green house gases. The photocatalytic field faces several challenges towards their industrial deployment under competitive scale. Several knowledge gaps exist in the design and understanding of photo-active materials mimicking the organic reactions catalysed by nature. The training tasks in PHOCAT, under the supervision of Prof. Arias (Host, EHU, Spain) and a 4-month secondment period with Prof. Ravelli (UNIP, Italy) will provide the researcher with new skills in chemical reaction engineering, material science and operando spectroscopy. PHOCAT will explore new chemical engineering concepts, related to photocatalyst design, catalysis, spectroscopy and engineering in order to enhance CO productivity from CO2 and H2O reactants. Specifically, PHOCAT will tailor the electronic and redox features in C3N4 materials, tested under unprecedented capillary solvation methods and operando synchrotron XAS. This scientific approach will contribute to design innovative photocatalytic process with potential industrial application. This MSCA-PF will certainly contribute the researcher to be trained in new scientific and transferable skills, enhancing the career perspectives to become an independent and mature researcher in the EU in the near future.

Keywords: heterogeneous catalysis,reaction mechanisms,photo reactions
BioSim M2M: Molecules to Medicine (biosim m2m)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 3570750.0
EU funding (EUR): 2499525.0
Participants: 1
Project status: SIGNED

BioSimulytics has developed breakthrough technology combining quantum physics, computational chemistry, machine learning, and high-performance computing to boost the success rates of pharmaceutical R&D. The BioSimulytics invention (patent EP3948877A1), is being applied to crystal structure prediction (CSP) for determining the most stable crystal structure or polymorph of a drug compound, as well as the most stable binding poses in protein-ligand complexes. Existing state-of-the-art techniques for polymorph analysis require long and painstaking experimentation by material scientists with uncertain results (<1% success rates). BioSim M2M will reduce the time to find the most stable crystal structures of a molecule from 3 months to 3 weeks and reduce candidate experiments from 400 to 40. As a result, BioSim M2M will contribute to the Pharmaceutical Strategy for Europe by helping to ensure that patients have access to high quality, effective, and safe medicines.
Understanding the role and biogenesis of transfer RNA-derived small RNAs in plants (UNROOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

This proposal aims to explore the precise mechanism, overall impact and complete population of the small RNAs derived of transfer RNAs (tsRNAs) in plants. The proposed research would be carried out in a laboratory that specializes in RNA regulation and that made substantial contributions to the plant tRNA-derived sRNA field (Dr. German Martinez). Although it has been described that these molecules are highly expressed in stress conditions, we still lack a clear understanding of the biogenesis pathways that lead to tsRNA accumulation, as well as of the array of biological processes they influence and their mechanism of action. Additionally, because of the widespread presence of RNA modifications in these molecules, the unbiased genome-wide quantification is not possible with the conventional sequencing technologies. Therefore, these molecules represent a largely uncharacterized stress-responsive regulatory network in plants, and thus an exciting source of potential applications for agriculture. The experimental approach of this project will use a model plant (Arabidopsis thaliana) in order to characterize the tsRNA population and evaluate the importance of this regulatory layer under viral stress. First, a method to compare the accumulation profiles of tsRNAs based on the enzymatic removal of RNA modifications will be implemented. Second, the biogenesis pathway of tRNA-derived sRNAs will be studied using mutant plants, and how this affects viral infection will be evaluated with these mutant plants. Third, the genes targeted by tRNA-derived sRNAs will be identified using a combined approach based on the immunoprecipitation of crosslinked AGO proteins and ribosome profiling that determines the translation rate. Overall, the data that this project would obtain has the potential to shift our understanding of tsRNAs and provide cutting-edge applications for agriculture. Thus, the completion of this project would provide me a considerable professional maturity.

Keywords: transfer rna small rna arabidopsis plant virus
A drug screen for enhancers of adult neurogenesis in ageing: Drosophila as a new translationally-relevant platform (Droscreeneuro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-04-30
Duration (months): 32.0
Total project cost (EUR): 237109.2
EU funding (EUR): 237109.2
Participants: 7
Project status: SIGNED

Ensuring a healthy lifespan in an increasingly ageing society represents a priority and a challenge for research and innovation. Particularly, irreversible neurodegenerative conditions are becoming hallmarks in the elderly, imposing a severe socioeconomic burden and ultimately threatening quality of life. Promoting adult neurogenesis has the potential to rejuvenate neural circuits restoring cognitive functions. High-throughput models of adult neurogenesis can expedite the identification of mechanisms and compounds for the development of neuro-regenerative therapies. I have evidence for physiologic and drug-induced adult neurogenesis in the genetically conserved and highly tractable model Drosophila melanogaster. Here, I aim to i) characterize adult neurogenesis across Drosophila’s lifespan; ii) identify drugs promoting neurogenesis in ageing in vivo, using the Drosophila olfactory circuit as an experimental platform; iii) test primary drug hits for their potential to promote neurogenesis on hiPSC-NSC in vitro (Host: UGOE, DE; Secondments: MPI-CE, DE; Weizmann, IL; DZNE, DE). Next, during a Non-academic placement in a translational drug discovery company, I aim to profile prioritized hits promoting neuronal regeneration (LDC, DE). My unique background in chemical engineering and biosciences will be pivotal to successfully complete this project. By leveraging state-of-the-art tools and support from experts in the field, Droscreeneuro represents an innovative, ambitious, and translationally-relevant approach towards the development of regenerative therapies aimed at counteracting age-related neurodegenerative diseases. Dissemination of results between specialized and general audiences will make science open to all. Ultimately, exposure to high-quality training in the academic and non-academic sectors will substantially enhance my skills and career perspectives, to conduct research in academia and industry to promote society's wellbeing.

Keywords: in vivo drug screening,adult neuronal regeneration,nervous system rejuvenation,learning and memory,sensory systems,drosophila,hipsc,nsc,transcriptomics,drug profilling,industry
Use of supported Nickel Catalysts for the synthesis of Sustainable Aviation Fuel (UNiCSAFe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Nowadays, the Sustainable Aviation Fuel (SAF) production is insufficient to cover the growing needs of the aviation sector. The European Commission has set a target for fuels supplied to EU airports to contain 70% SAF by 2050, representing a quantity of 40 million tons of SAF. To address this challenge, UNiCSAFe aims at developing new efficient and sustainable catalysts for alkylbenzene synthesis (SAF precursor). Alkylbenzene are synthesized by oligomerization of ethylene followed by Friedel Crafts alkylation of aromatic compounds (both precursors can be produced from biosources or CO2). All effective processes described in the literature are based on homogeneous catalysts (with a large excess of AlCl3) which prevents the easy separation of catalyst from the desired SAF precursor. To circumvent this, the Surface Organometallic Chemistry (SOMC), combining the advantages of both heterogeneous and molecular chemistry (well-defined catalysts that can be easily recycled), is a powerful approach that will allow the synthesis of new supported nickel catalysts for the tandem ethylene oligomerization/Friedel-Crafts alkylation. The rational development of such catalysts will be tackled by combining experimental and theoretical means. Beyond synthetic work and catalyst evaluation, the project targets a better understanding of the reaction mechanism, allowing fine-tuning of the second generation of catalysts (more efficient, selective and sustainable) for SAF precursor synthesis. In conclusion, UNiCSAFe represents a first step toward the development of a technology for SAF production, which is a gateway to increase the share of renewable energies in aviation industries. The UNiCSAFe project merges advanced organometallic chemistry, including SOMC, catalysis and both experimental and theoretical mechanistic investigation. Thus, it provides an excellent platform to develop and bolster my scientific- and soft-skills, and strengthen my profile to pursue my own independent career.

Keywords: surface organometallic chemistry,catalyst development,nickel catalysis,mechanistic studies,dft calculation
Politics of Grievance and Democratic Governance (PLEDGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Finland,Ukraine,Greece,United Kingdom,Sweden,Germany,Poland,Belgium,Spain,Türkiye,Hungary
Call: The emotional politics of democracies (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2771272.5
EU funding (EUR): 2771272.5
Participants: 15
Project status: SIGNED

Contemporary politics is angry and vengeful, with affective polarization and uncompromising antagonisms posing a significant challenge for European democracies and their governance. PLEDGE interprets political grievances as emotional signals of disaffection, frustration and insecurities that can develop into either anti- or prodemocratic outcomes. By engaging in collaborative research design and implementation involving academics, policy-makers, civil society actors, and citizens, the PLEDGE project intends to offer new understanding of anti- and pro-democratic trajectories of political grievances, and to co-create tools and practices of emotionally intelligent and responsive democratic governance and policy communication that promote prodemocratic forms of civic engagement. The project will provide a framework of the emotional mechanisms of anti- and prodemocratic grievance politics that explain dynamic interrelations between the emotions, values, and identities of citizens and groups, and empirically decode the psychological, sociocultural, and political drivers of these emotional mechanisms into operationalizable measures and indicators, focusing on 11 countries and 3 major crises (pandemic, war in Ukraine, climate/energy crisis). PLEDGE will achieve these objectives through a cross-national interdisciplinary research project involving 15 partners and its policy outputs, co-created and piloted in design coalitions, will inform democratic innovation of processes and practices and incorporate emotions in the designed-for outcomes, thus improving their efficiency.

Keywords: emotions,values,identities,grievances,emotional mechanisms,democratic innovations