Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of CD1c-reactive T cells and lipid antigens in post-streptococcal disease (CReativeLipid)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1491316.0
EU funding (EUR): 1491316.0
Participants: 1
Project status: SIGNED

Most T cell immunology knowledge is centered on T cell receptor (TCR) recognition of peptides presented by major histocompatibility complex (MHC) molecules. MHC class I-like CD1 proteins present lipid antigens to T cells, but it is becoming increasingly clear that the rules of lipid engagement show fundamental divergence from those of peptide recognition. As CD1 proteins are relatively monomorphic, solving the fundamental biology of lipid recognition opens the potential for wide therapeutic benefit. Group A Streptococcus (GAS) infection is associated with multiple autoimmune sequelae, yet the disease mechanisms are largely unexplained. Recent increases in GAS infection globally have re- emphasized the major unmet medical need, and driven focus on capitalizing on the therapeutic window prior to the onset of post-streptococcal autoimmunity. I hypothesize that lipid antigens derived during GAS infection break immune tolerance through molecular mimicry of self-lipids and contribute to disease. This proposal harnesses multiple recent technological advances to investigate both CD1c mechanisms and translational implications of lipid-mediated reactivity in humans. I will examine CD1c tissue immunology pathways using human tonsils, a common GAS infection site. GAS- mediated CD1c-relevant cellular and molecular mechanisms will be studied through T cell and lipid antigen discovery and will develop therapeutic targeting approaches. Identified mechanisms will be further studied in patients with post-streptococcal glomerulonephritis (PSGN), informing disease relevant host-pathogen interactions. Access to patient samples, alongside established experimental platforms and a strong collaboration network places me well to address fundamental immunological mechanisms and facilitate preventive strategies for post-streptococcal disease, as well as enabling the wider field to reach the point of industry engagement to drive patient benefit.

Keywords: group a streptococcus
The role of olfactory sensitivity on task specialization in a social insect (OLFATASK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1864575.0
EU funding (EUR): 1864575.0
Participants: 1
Project status: SIGNED

Division of labor and task specialization are key elements explaining the remarkable ecological success of human and animal societies. Social insect colonies are characterized by a highly effective division of labor, with workers specializing in brood care early in life and in foraging later in life. Various theoretical models have been proposed to explain division of labor, most prominently the response threshold model, which postulates that individuals differ in their response threshold to task-associated stimuli, and will engage in particular tasks depending on this threshold. While this model has received some experimental support, the current data still do not explain how division of labor is implemented for all different tasks of a social insect colony. How is division of labor implemented? The success of social insect colonies lies in the capacity of all its members to behave in a well-organized manner, which involves elaborate communication among colony members. Accordingly, ants, wasps and bees use a wide range of pheromones, intraspecific chemosensory messages, to regulate almost every aspect of their life. Astonishingly, the role of olfaction, the main sensory modality used by insects, on the division of labor has been greatly overlooked. Using the honey bee Apis mellifera as a model, I propose and will investigate the groundbreaking hypothesis that variation in olfactory perception and processing, especially regarding social pheromones, can give rise to division of labor. I will use a novel approach in social insects, based on newly developed neurogenetic tools. I will compare olfactory perception and processing in the hive’s different worker task groups (nurses, foragers etc.) and will experimentally manipulate the activity of neural circuits involved in pheromone information processing, while following bees’ behavior and task allocation. In the end, Olf@Task aims to definitively establish the role of olfactory perception on the division of labor.

Keywords: honey bee,division of labor,pheromone,brain
Fostering rights and agency with girls and women with disability from culturally minoritised groups (FRIDA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Austria,Germany,Italy,North Macedonia,Slovakia,Colombia,Peru,Tanzania, United Republic of,Ecuador,Poland
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 1738470.0
EU funding (EUR): 1738470.0
Participants: 15
Project status: SIGNED

Society is still far from fully achieving the rights of people with disabilities, especially girls and women from culturally minoritised groups. Analysing inequality from an intersectional perspective allows us to highlight how disadvantage derives from an interweaving of conditions that, taken in isolation, fail to capture the serious discriminatory effects that result from their intersection. FRIDA's objective is to design actions that promote the agency of girls and women with disabilities from culturally minoritised groups in the educational, work and family spheres, based on a legislative mapping of progress in the fundamental rights of these people in each country. The consortium comprises 10 academic entities (4 from Latin America and one from Africa) and 5 non-academic entities from 11 countries. From an interdisciplinary perspective, it aims to define priorities that reflect the demands of girls and women with disabilities from culturally minoritised groups, as well as the barriers and levers in educational, employment and socio-family services through an inclusive research methodology to advance in the design of innovative and inclusive proposals, promoting the democratisation of research processes and the exchange of good inclusive practices.The main results of the project will be the elaboration of an International comparative report on the rights of girls and women from an interseccional perspective, a Toolkit for practitioners to promoting the agency for these girls and women in the educational, work and family spheres and the creation of an interactive online platform to make visible or denounce oppressive situations and to share and respond to the priorities expressed by these girls and women. It also includes recommendations for policy-makers and researchers to optimise community resources and to generate inclusive research projects, promoting innovative actions for the agency of girls and women with disabilities from culturally minoritised groups.

Keywords: disability,gender studies,human rights,cultural minorities
Rejecting Race: The Intellectual Origins of Racial Deconstructivism, 1784-1950 (Rejecting Race)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-02
End date: 2027-05-01
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

It is now a truism that race is a social and cultural construct, but when was this first realised, why, and by whom? Rejecting Race: The Intellectual Origins of Racial Deconstructivism, 1784-1950 investigates the process by which it became accepted that race is an intellectual fiction rather than a real reflection of the world and its peoples. While the existing literature has traditionally identified the United Nations Educational, Scientific, and Cultural Organization (UNESCO) Statements on Race that began appearing in 1950 as the first sustained challenge to the concept of race, Rejecting Race examines a range of thinkers who undermined the epistemological foundations of race well before the middle of the twentieth century. This historical study will use genealogical and comparative methods of textual analysis to examine selected philosophical, linguistic, anthropological, sociological, and historical texts written in English, French, and German. It is hypothesised that these will show how initial reservations about the idea of race expressed at the end of the eighteenth century developed into full-blown rejections of race as an intellectually valid category by the end of the nineteenth century, providing the essential framework for the movement that culminated in the UNESCO Statement on Race of 1950 that declared it a ‘social myth’. In undertaking a historical examination of when, how, and why race began to be challenged and reconceived in constructivist terms, this project will substantially revise the prevailing state-of-the-art by showing that race was a contested idea from its inception, a fact raising the troubling question of why it retained its hold on Western minds for so long.

Keywords: race,anthropology,sociology,knowledge
New Trends of Non-Hermitian Topology in Open and Correlated Quantum Systems (NTopQuant)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1496250.0
EU funding (EUR): 1496250.0
Participants: 1
Project status: SIGNED

Non-Hermiticity plays a central role in describing open systems, which in recent years has been investigated in the context of topology revealing a dramatic enrichment of the phenomenology of topological phases. A particular focus has been on the appearance of truly non-Hermitian (NH) degeneracies known as exceptional points (EPs) at which not only the eigenvalues but also the eigenvectors coalesce. In their most elementary form, EPs reveal intriguing phenomena, such as unidirectional transmission, and one-sided visibility. Due to the novelty of the field, research has only recently started to dive into the topic of higher-order EPs, and the importance of EPs beyond classical systems. NTopQuant elucidates the role played by exceptional nodal phases in open and correlated quantum systems by providing a new perspective on open quantum materials. NTopQuant not only paves the way towards gaining profound insights into the properties of higher-order exceptional nodal phases, but also expands our understanding of open and correlated quantum systems. Making connection to experiment, NTopQuant studies nonlinear optical systems in close collaboration with experimentalists at the host institute. While EPs are typically realized in coupled systems, we focus on single devices thus proposing a new path towards studying EPs in optical systems. Equally relevant for experiment are Moiré materials, which are powerful quantum simulators realizing exotic strongly correlated phases. NTopQuant investigates these materials in their open form, which not only results in a new research direction but also paves the way towards studying NH effects in strongly correlated systems in the lab. The PI is considered an expert in NH topology, and the host institute offers a vibrant scientific environment. As such, they form the perfect combination for carrying out this highly interdisciplinary research program with the goal to establish a novel perspective on open and correlated quantum systems.

Keywords: non hermitian topology,open quantum systems,nonlinear optics,moir superstructures
Tough colloidal biomaterials for regeneration of load-bearing tissues (BigelInk)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Musculoskeletal conditions impact the patient’s mobility and dexterity. This greatly affects the patient’s ability to work and their overall quality of life. This burden could be lifted by tissue engineering and regenerative medicine solutions, which utilizes a combination of biomaterials and cells to restore functional tissues. Current biomaterials do not provide the strength needed for use in load-bearing applications as those seen in musculoskeletal conditions. BigelInk will develop a novel biomaterial formulation that mimics the mechanical properties of the native scaffolding of load-bearing tissues. It will do this by the design of a colloidal bigel, a two-component nanoparticle system with interpenetrating phases that is both tough and soft. The developed biomaterial will be tested for its biocompatibility according to world standards to enable further clinical trials. The biomaterial generated in this project will thereby provide a novel platform for tissue regeneration of load-bearing tissues.

Keywords: colloidal hydrogel,regeneration,bigel
SUstainable Preservation of Masonry Arch Bridges (SUPMAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Italy,Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2028-03-31
Duration (months): 30.0
Total project cost (EUR): 325434.9
EU funding (EUR): 325434.9
Participants: 3
Project status: SIGNED

SUSUPMAB project aims to develop, test, and validate a novel strategy for the sustainable management and preservation of masonry arch bridges (MABs) considering the unique features of these structures and their cultural heritage and social value. SUPMAB responds to the urgent need for cost-effective and sustainable techniques for extending the lifetime of MABs, many of which exhibit signs of distress. MABs are a vital part of transportation infrastructure and form part of our cultural heritage. Transport agencies and councils are facing significant challenges in managing and maintaining MABs. The limited funds allocated for risk management and mitigation mean that they need to correctly identify the structures more at risk to prioritize interventions. The increasing importance of environmental (i.e. climate change-related) considerations in the maintenance and renewal of infrastructure assets also means that factors such as energy and resource consumption and carbon emissions must be considered in addition to monetary costs in the decision-making process. Finally, the actions taken by bridge managers (e.g. closure, retrofit) must be soundly justified and accepted by the communities affected. SUPMAB aims to develop a novel multi-criteria framework for MAB risk management practice to aid decisions concerning the inspection, assessment, monitoring, operation and repair/strengthening of these structures. Based on Bayesian decision theory, the proposed framework considers several overlooked attributes of enhanced condition assessments, such as modelling/analysis sophistication and knowledge/information content, and environmental and social indicators in addition to economical ones, to define optimal management and maintenance strategies for MABs. The proposed framework can extend further the life of MABs and preserve these cultural heritage assets for future generations by promoting the implementation of cost-effective, sustainable, and shared management strategies.

Keywords: masonry arch bridges cultural heritage advanced modelling structural health monitoring multiple attribute utility theory contingent valuation
Relative Langlands Functoriality, Trace Formulas and Harmonic Analysis (RELANTRA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1409559.0
EU funding (EUR): 1409559.0
Participants: 1
Project status: SIGNED

The Langlands program is a web of vast and far-reaching conjectures connecting seemingly distinct areas of mathematics that are number theory and representation theory. At the heart of this program lies an important principle called functoriality, that postulates the existence of deep relations between the automorphic representations of different groups, as well as related central analytic objects called automorphic L-functions. Recently, a new and particularly promising way to look at these notions, and that has come to be called the relative Langlands program, has emerged. It essentially consists in replacing groups by certain homogeneous spaces and to study their automorphic or local spectra. As for the usual Langlands program, trace formulas are essential tools in the relative setting both to tackle new conjectures than to deepen our understanding of the underlying principles. A main theme of this proposal would be to make fundamental new contributions to the development of these central objects in the local setting notably by: (1) Studying systematically the spectral expansions of certain simple versions especially in the presence of an outer automorphism (twisted trace formula) (2) Developing far-reaching local relative trace formulas for general spherical varieties making in particular original new connections to the geometry of cotangent bundles. These progress would then be applied to establish new and important instances of relative Langlands correspondences/functorialities. In a slightly different but related direction, I also aim to study and develop other important tools of harmonic analysis in a relative context, including Plancherel formulas and new kind of Paley-Wiener theorems, with possible applications to new global comparison of trace formulas and factorization of automorphic periods.

Keywords: automorphic forms langlands program l functions trace formula harmonic analysis
Development of a robotic maintenance system for wind turbine blades (Romain)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,United Kingdom,Portugal,Latvia
Call: AI, Data and Robotics for the Green Deal (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 2653362.5
EU funding (EUR): 1981831.0
Participants: 9
Project status: SIGNED

The wind energy sector continues growing rapidly even under the pandemic, as an estimated 93GW wind capacity was installed in 2020 globally. After installation, wind turbines are expected to run around 20-25years, during which O&M (operation and maintenance) becomes crucial in maximising the economic and environmental benefits of wind assets. This project aims to develop a complete solution for robotic based inspection and repair of wind turbine blades (WTBs), both onshore and offshore. Firstly, we will integrate thermography and shearography with laser heating, so that advanced lock-in techniques will be achieved for in-situ inspection of both surface and subsurface defects within WTBs. (Current techniques including drone-based are limited to surface defects only). Secondly, a compact and efficient robotic deployment system will be developed which will hold the inspection unit and a robotic repair arm. The robotic system will be operated by engineers working on ground (for onshore wind farms) or on a vessel (for offshore wind farms). When defects are detected and deemed reparable, the repair arm of the whole system will be activated to rapidly repair the faulty area of composite components by resistance welding for joining and/or disassembly. Comparing to the traditional adhesively bonding for repair, the proposed resistance welding with optimised processing would significantly reduce the curing cycles/time with much fewer preparation for surface treatment steps while it will be more easily designed to integrate with robotic arm. The whole system will be operated remotely by engineers working on ground or on a vessel without risking their lives working in the sky on WTBs. Field trials on wind towers will be conducted to validate the system.

Keywords: wind turbine blades,robotics,operation and maintenance,inspection,repair,remote control