Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Random Unitaries in a Rapid Optical Lattice Simulator (UniRand)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1497701.0
EU funding (EUR): 1497701.0
Participants: 2
Project status: SIGNED

Quantum information theory points to new ways of classifying matter. Instead of focusing on microscopic correlation functions, it hinges on global properties of quantum states such as the presence and scaling of entanglement entropy. This general strategy relates systems of vastly different scales, for example black hole physics to information propagation in microscopic quantum systems. UniRand will realize a new, widely applicable approach to measuring global quantum state properties using ultracold atoms. At the heart of the protocol are random unitary transformations, which are applied to a quantum state before measurement. The fluctuating outcomes of measurements under random transformations encode global properties of the density matrix, including Renyi entropies and state overlaps. We are specifically interested in systems of mobile particles in optical lattices. Random unitary protocols will give access to new physics: (1) The dynamics of information scrambling as quantified by out-of-time-order correlators and (2) the order parameter-independent characterization of quantum phase transitions through measurements of fidelity. We will probe both aspects in one-and two-dimensional bosonic Hubbard systems. Our approach will be realized on a new, high-performance quantum simulator that assembles many-body systems from individually laser-cooled atoms with a high repetition rate. Protocols based on random unitaries in ultracold atom systems will open a new toolbox for system-level measurement and enable direct links between quantum information theory and experimental quantum science.

Keywords: optical lattices
Living Alone CONsumption ImpAct (LACONIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2024-01-24
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

Human population has wide ranging and often negative consequences for the natural environment. Population stability and decreasing fertility have thus been heralded as promising for sustainability. However, household size has been decreasing steadily in both developed and developing countries, at an accelerating pace, since the 1980s. The European Union (EU) leads this trend, with nearly a third of total households consisting of single residents. As a result of more people living alone with associated higher consumption, slowing population growth has resulted in neither fewer residences nor decelerating human impact on the environment. This MC-IF aims to investigate the trend toward living alone and create new knowledge about environmental impacts of different household configurations, drivers for different occupancy trends and alternative sustainable housing configurations. The research will be carried out in three phases, firstly by using existing population, housing and consumption databases; secondly be interviewing both high and low impact single resident households and finally by studying low impact household configurations in-depth. This will provide new knowledge on: how different household configurations impact sustainability; why people choose to live in different various configurations; and drivers and barriers for emerging sustainable alternatives. This knowledge will be valuable for policy makers planning sustainable urban environments. During period of training the ER will: Acquire specialised knowledge on sociology of consumption; deepen her mixed methods analysis; improve her multicultural and team communications skills; have policy impact; and publish scientific articles in international journals. Thus the MSCA-IF will allow her to consolidate her academic profile in order to enter the EU academic job market in a tenure-track position.

Keywords: sociology of consumption,social practices,sustainability,housing,water,energy,transitions
Connecting ethology to the social sciences: A primatological analysis of human bystander behavior during conflicts (SOCIOETHO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2025-05-02
Duration (months): 36.0
Total project cost (EUR): 263358.72
EU funding (EUR): 263358.72
Participants: 1
Project status: SIGNED

Primatology provided extensive evidence of non-human primate behavior during conflicts claiming a behavioral universality shared with human primates. However, little is known about human behavior during conflicts because direct and undisturbed naturalistic observations of humans are rare. Recently, social scientists started to fill this gap by observing adult human behavior in real-life conflicts using Closed Circuits Television (CCTV). These systematic and unobtrusive observations of adult humans provided evidence for behavioral continuity between human and non-human primates during conflicts but currently lack integration with theories and methodologies from ethology. This project aims to connect ethology to the social sciences by testing theories of bystander conflict behavior from primatology on CCTV camera observations of human adults in 500 conflicts. It integrates methodological standards for observational studies from ethology in the social sciences, and provides motivational explanations of bystander actions in conflicts for the benefits of observational studies in both fields. The integrative methodology adds to both primatology, by providing understanding of human behavioral continuity in the primate order, and to sociology, by providing an evolutionary perspective on human behavior in the context of bystander conflict management. In turn, by conducting the project, I will acquire, as primatologist, an inclusive theoretical understanding of bystander interventions in primates, including the human species that will launch me into an interdisciplinary career.

Keywords: homo sapiens,primates,conflict management,observational method
Development of inovative multi-target drugs for ALS (MTD4ALS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Amyotrophic Lateral Sclerosis is a severe neurodegenerative disease characterized by the degeneration of the upper and lower motor neurons (MN), ultimately leading to patient death by respiratory failure. Despite being the most common adult-onset motor neuron disease, the drugs available till now are symptomatic and only extend patients life expectancy a few months without changing the onset of the disease. Recent studies revealed that NF-κB transcription factor is the major regulator of neuroinflammation in ALS. Therefore, inhibitors of NF-κB signalling pathway can be considered key tools for the development of novel therapies for ALS. Additionally, the use of iron chelators have also shown potential to increase ALS survival through the regulation of iron redox activity and by triggering MN cell survival mechanisms through the mild activation of HIF transcriptional factor. In this project we propose an innovative therapeutic solution for ALS based on the design and syntheses of multitarget small-molecules capable to modulate NF-κB activity through inhibition of IKKβ protein and prevent/minimize the iron induced oxidative damage and/or stabilize HIF. The project encompasses the rational design and synthesis of a library of small molecules that will be submitted to an initial cascade of biophysical and chemical assays to evaluate their binding affinity and iron chelation properties. Subsequently ALS cellular models will be used in order to validate target engagement inside cells, as well as, to identify the small-molecules that could protect MN from oxidative-stress and inflation driven apoptosis. At the end of the project it is expected to propose a novel lead compound that will be optimized and its performance evaluated in ALS animal models. This project combines the expertise available in academia and industry to validate a new therapeutic approach for ALS and, provides an exceptional training opportunity to prepare a young researcher for his future career.

Keywords: multi target drugs,nf kb,drug dyscovery
beSCIENCEd - Bringing science and research directly to the young people (beSCIENCEd)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-04-01
End date: 2017-11-30
Duration (months): 20.0
Total project cost (EUR): 153811.25
EU funding (EUR): 153811.25
Participants: 1
Project status: CLOSED

The main goal of beSCIENCEd is to bring the general public and especially young people closer to the exciting world of research and to show that science is fun and accessible for everyone. Scientists from almost all significant research institutions in Vienna are going to participate in the event and present their recent research results in order to generate enthusiasm among young people for science and research. A focus is laid on the fields science, technology, engineering and mathematics (STEM) and the exiting topics cover informatics, mobility, energy, construction, biology, chemistry, mathematics, and automation. Thus, it is shown how broad research can be. Every topic can and will be looked at and interpreted in a different ways and our program is going to cover all these aspects. The beSCIENCEd program will integrate researcher talks, hands-on workshops as well as a range of ongoing activities by the exhibitors and social activities like science cafes where visitors can get in direct touch with scientists and their research. To increase the interest of more young people in research careers, also the opportunities of research during the school time will be shown by the presented projects of the Austrian Sparkling Science initiative as well as by the projects of student researchers active in various research projects. Moreover, to encourage entrepreneurial thinking of young people, a few Viennese innovative start-up companies are going to present their innovation and business cases. To grasp technology with own hands, a series of workshops is provided for different age groups. The social events are aimed at showing that researchers are ordinary people with extraordinary jobs and that research is also much about communication and international cooperation. As the events will take place in Vienna’s biggest high school with approximately 2800 students, science comes directly to the young people. Become a part of science, beSCIENCEd!

Keywords: science fair,researcher,workshop,science slam,exhibition,talks,science cafe,school,young people
TheMotion: Revolution in Motion (THEMOTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

e-Traction Europe, a highly innovative company specialized in energy efficient electric powertrain technology, is developing a direct-drive in-wheel electric powertrain solution for city buses as well as for medium and heavy duty trucks, which is called TheMotion. By creating the most energy efficient electric powertrain solutions, environmental impact, energy consumption and cost of ownership of mobility are lowered substantially. TheMotion is the only direct-drive in-wheel electric powertrain system on the market for buses and medium and heavy duty vehicles. The main advantages of TheMotion, direct-drive in-wheel electric powertrain solution are: • Zero emission system (huge contribution to lowering CO₂ emissions and air quality); • Significant noise reduction; • High efficiency (e.g. maximum elimination of transmission losses and optimal regeneration); • Decrease of the total cost of ownership; • Flexible production method and assembly makes product suitable for retrofit and new vehicles; • Design freedom for OEM (optimum use of available vehicle space due to very low build height of the axle). Potential users are public transport operators, bus manufacturers and manufacturers of medium and heavy duty trucks (OEMs). The objective of this feasibility study is to further verify the technological, practical as well as the economic viability of the product. The 6 months of Phase 1 will be used to develop a detailed business plan, strengthen the relationship with potential customers and partners and define the technology. e-Traction intends to submit a Phase 2 application after finishing Phase 1.

Keywords: direct drive in wheel electric powertrain,zero emission,electric vehicles
Geometries of Exotic NuclEar StructurE 17 (GENESE 17)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2021-11-01
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 2
Project status: CLOSED

This project deals with the theoretical description and explanation of the phenomenology of geometries manifested in the shapes of exotic nuclei. The phenomenology concerns low-energy states of a nucleus under study and transitions between them. The project consists of two parts. Part I will provide theoretical descriptions of experimental data, chiefly taken in GANIL with Radioactive-Ion Beams, related with shape coexistence (objective GN1), pear-shaped nuclei (GN2) and shape/ phase transitions (GN3). The theoretical models to be used are the Geometric Collective Model (GCM) and the Shell Model (SM). Part II will introduce conformal symmetry in nuclear structure as a means to explain the occurrence of nuclear shapes. It will be introduced in the SM (GN4) to investigate the emergence of the GCM from complex many-body calculations. This will be achieved by extending the SU(3) model of quadrupole deformation and a related description of octupole deformation through algebraic methods used in classical Yang-Mills theories. Conformal symmetry will also be introduced in the GCM (GN5) as a means to import higher symmetries in the GCM and investigate their relation with single-particle effects. This will be achieved based on a geometric method using formal correspondences with cosmological models, recently explored by the candidate. These correspondences will be extended to methods used in the gravitational multipole moments with the aim to propose the conformal symmetry of space as a fundamental symmetry of the nuclear multipole moments. In parallel, patterns of conformal symmetry in nuclear structure will be investigated numerically within the Interacting Boson Model. The theoretical results of Part II will be examined in shape coexistence, pear shaped nuclei and shape/phase transitions. During this entire project precious transfer of knowledge will occur between the candidate, the supervisor and the experimental groups in GANIL.

Keywords: nuclear structure,exotic nuclei,shape coexistence,pear shaped nuclei,shape,phase transitions,conformal symmetry,shell model,geometric collective model,interacting boson model
Deep Learning Powered Holographic Microscopy for Biothreat Detection on Field (HoloZcan)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Italy,Poland,Poland,Hungary,France,France,France,Netherlands
Call: Chemical, biological, radiological and nuclear (CBRN) cluster (H2020-SU-SEC-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 4380400.0
EU funding (EUR): 4380400.0
Participants: 9
Project status: SIGNED

HoloZcan brings a new tool for security actors (police, relief workers, disaster managers, crisis managers, stakeholders responsible for public safety, critical infrastructure, and service providers) notably in the fields of autonomous detection and response capabilities. The project will increase (environmental and exhaled) bio-aerosol sensing/measurement capability of CBRN practitioners by developing a high resolution, large throughput, automatic and highly portable detection system for making automatic classification of pathogens and particles. HoloZcan develops of a novel holographic microscopy and imaging technology for rapid and cost-efficient screening of potential biological threats and unknown, potentially dangerous substances, combined with methods of artificial intelligence and machine learning. It establishes a framework of a dynamic feature selection and validation algorithm to support the continuous innovation capability of the system in the field of adaptive learning and database optimization for specific bioinformatic applications. The project also develops comprehensive and innovative means of respiratory, ventilation and environmental biological data sampling that can be used in real-time, standoff or in mobile bio-detection context. The project indicates the HoloZcan technique versatility for a wide range of applications and demonstrates its technical feasibility. The project responses to the actual needs of European practitioners and technological gaps identified by the ENCIRCLE project as indicated in the ENCIRCLE Catalogue of Technologies and addresses several shortcomings of the current approaches to bio-threat agent detection. The HoloZcan project applies a flexible adaptive approach to design and CBRN practitioners are engaged as project partners or as external stakeholders in the process.

Keywords: cbrn,biothreat detection,digital holographic microscopy,aerosol,pathogens,field microscopy
A synthetic biology approach to engineering exhaustion-free T cell therapies. Uncovering and counteracting biomechanical triggers of T cell dysfunction in the tumour microenvironment. (Tex-Mex)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-15
End date: 2023-10-04
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Cancer is the second leading cause of death in the European Union, having killed 1.4 million people in 2018 alone. Chimeric antigen receptor (CAR) T cell therapy is a ground-breaking cancer treatment that has demonstrated striking results in fighting blood cancers. However, T cell exhaustion, a process that results in the progressive development of lymphocyte dysfunction due to prolonged antigen stimulation in cancer, chronic inflammation or infection, has been a major obstacle in translating CAR T cell therapy to solid tumours. The solid tumour microenvironment is biomechanically distinct from physiological conditions, being characterized by higher interstitial pressures, higher stiffness and a distinctive vascular architecture. While biochemical triggers for T cell exhaustion have been well characterized, biomechanical influences are understudied. This project seeks to (i) use a microfluidic model to add the biomechanical dimension to our current understanding of the development of T cell exhaustion and (ii) use synthetic biological approaches to engineer “biomechanosensor-actuator devices”. These will be intracellular systems based on synthetic biological circuits that will integrate biochemical and biomechanical cues of T cell exhaustion and trigger genetic pathways to counteract the development of dysfunctional phenotypes. Integrating the biomechanical and biochemical dimensions will yield a more sophisticated cell therapy platform to neutralize T cell exhaustion. Ultimately this would provide a safer, more effective and universal treatment for cancer by preventing T cell exhaustion and immune escape.

Keywords: synthetic biology,t cell exhaustion,biomechanics,microfluidics,3d scaffolds,tumour architecture