Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CLimate change, Extreme weather and Air quality anomalies Resilience through novel Earth Observation advanced data analytics (CLEAR-EO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Italy,Greece,United Kingdom,Austria,Denmark,France,Norway
Call: Develop innovative applications to support the European Green Deal, building on meteorological satellite data (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 3999270.0
EU funding (EUR): 3999270.0
Participants: 11
Project status: SIGNED

CLEAR-EO leverages on newly available satellite data like Meteosat Third Generation (MTG) and EUMETSAT Polar System Second Generation (EPS SG), along with European Cloud infrastructures like the European Weather Cloud, to develop an analysis and geo-spatial notification system on top of a federated data space. These core components will support the development of innovative applications and services such as on-demand decision making workflows for 1) flash floods in urban areas, 2) short and long-term Climate Change impacts adaptation in agriculture, and 3) accurate air quality forecasts, with the final goal to contribute and enhance the Copernicus and the EO/weather services ecosystem. CLEAR-EO teams up a multidisciplinary partnership from Research Organizations, weather forecasting centres, EO data and tech/cloud platform specialists to Group of Earth Observation (GEO)/Destination Earth (DestinE) contributors and SMEs to develop, demonstrate, and promote to relevant stakeholders and end-users new application developments and early exploitation of the new weather satellite data to support SDGs and European Green Deals.

Keywords: meteosat third generation,in situ data,geospatial notifications,extreme weather events,flood,drought,eumetsat polar second generation,copernicus,european weather cloud,data space,
SYSTEMEU: Fostering Systemic Innovation and Digital transformation across European innovation ecosystems. (SYSTEMEU)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: COFUND actions
Countries involved: Germany,Spain,Romania,Bosnia and Herzegovina,Portugal
Call: Implementing co-funded action plans for connected regional innovation valleys (HORIZON-EIE-2023-CONNECT-03, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 14870562.5
EU funding (EUR): 7435281.25
Participants: 20
Project status: SIGNED

SYSTEMEU is an initiative aimed at transforming European innovation ecosystems through open innovation by fostering digitalization in healthcare, energy, and mobility. It unites five regional ecosystems, fostering inclusivity and collaboration among universities, incubators, public organizations, government agencies, and innovation centers from Germany, Romania, Portugal, Bosnia and Herzegovina, and Spain. SYSTEMEU addresses the issue of traditional innovation efforts' limited focus on societal and environmental transformation, introducing a systemic and long-term perspective. By fostering a collaborative and interdisciplinary environment, SYSTEMEU will enable adaptable policies and stimulate economic vibrancy, enhancing societal well-being and advancing European innovation. SYSTEMEU promises to create interconnected, inclusive, and more efficient innovation ecosystems, strengthen cross-border network collaboration through six cross-regional projects in project duration and others after the project end, expand global cooperation through existing networks of European actors and ecosystems, promote gender equality, and reduce territorial inequalities in access to innovation support, aligning with EU policies and strategies. SYSTEMEU's innovative approach aims to usher Europe into a regenerative world.

Keywords: systemic innovation,co creation,digitalization,healthcare,mobility,energy,startups,spinoffs,european innovation valleys,b2b and b26 co creation,interregional projects
Photo switchable activation of sigma-hole (HALO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Governing intermolecular interactions is crucial for i) controlling how molecules communicate within a molecular assembly, and ii) fine-tuning the physical and chemical properties of ordered materials. Halogen bonds (XB) and chalcogen bonds (ChB) are two sigma-hole interactions that are garnering significant attention across various fields such as supramolecular chemistry, crystal engineering, anion recognition, and catalysis, owing to their directionality and strong predictability. Among the numerous factors influencing the molecular organization of interacting partners, interaction strength plays a significant role. Its increase or decrease is pivotal in activating or deactivating recognition phenomena. Current strategies to optimize the recognition process are limited to strongly activated XB/ChB donors. The switching on/off (reversible control) of XB and ChB interactions has never been explored and could have valuable implications in virtually all fields where these interactions occur. This seems to be the next essential challenge in the realm of sigma-hole interactions and will be addressed by HALO. HALO aims to: (a) Photo-induced manipulation of the inherent electrostatics of heavier halogen/chalcogen atoms to toggle their involvement in electrophile∙∙∙nucleophile interactions on or off, (b) Exploit this control over interactions to develop new strategies for time-honored recognition processes, e.g., sensing of toxic anions like CN–, NO2–, AsO43–. While sigma-hole interactions have been known for decades, their photochemical activation has not been addressed until now. Notably, the hydrogen bond, the most utilized molecular interaction across interdisciplinary fields, does not offer any means for such electrostatic control. The breakthrough of this project lies in introducing reversibility to the state-of-the-art XB/ChB-based recognition strategies, paving the way for a new generation of XB/ChB-based light-responsive materials for green processes and devices.

Keywords: non covalent interactions,sigma hole interactions,halogen bond,chalcogen bond
A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds. (APTADEGRAD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Portugal,Belgium,United Kingdom
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2322037.5
EU funding (EUR): 2321677.5
Participants: 6
Project status: SIGNED

Diabetic foot ulcers (DFUs) a major complication of diabetes, occur in ~25% of patients, with a five-year recurrence rate of ~65% . DFUs often end in hospitalization, with limb amputations in up to 60% of cases . DFU related mortality is 5% within twelve months, rising to 42% after five years. Despite high prevalence and its major impact on the quality of life, no effective treatment has been approved, so DFU remain a highly unmet clinical condition. APTADEGRAD aims at obtaining in vivo proof-of-concept for a novel, first-in-class therapy using aptamer-based Lysosome Targeted Chimeras (LYTACs) to heal diabetic foot ulcers (DFUs). These LYTACs will target IL-1β, its receptor IL-1R1, and MMP-9 for degradation, proteins known to play a key role in impaired healing in diabetic wounds. Out hypothesis is that a) aptamer-based LYTACs MoA, may offer the potential to deliver a controlled, dose-dependent reduction of MMP9, IL-1b and its receptor IL-1R1, moderating the excessive DFU inflammatory response, while maintaining biologically beneficial levels of these proteins to promote healing and prevent infection; b) the simultaneous targeting of these relevant proteins will produce a synergetic effect in the inflammation cascade, providing superior efficacy outcomes. Should the main objective of the project is achieved (i.e. show efficacy in animal models of DFU), we would be showing for the first time a potential therapy based on LYTACs, in this case in the context of diabetic ulcers, with potential applications in other types of chronic wound or immune pathologies. In addition to efficacy data, we will be gathering essential knowledge about LYTACs (toxicity, efficacy, mechanism of action, differences with other approaches such as blocking or inhibition which are essential for successful future translation of the novel concept of LYTAC in pharmaceutical development to clinical trials.

Keywords: lytacs lysosome targeting chimeras,aptamers,diabetic food ulcers,diabetes,diabetic wounds,proteases,citokines,il 1,il 1r1,mmp 9
Material Science Innovation for Accelerated, Sustainable and Safe Implementation of Carbon Capture and Storage (MISSION-CCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway,France,United Kingdom,Denmark,United States,Netherlands,Sweden
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2929384.8
EU funding (EUR): 2929384.8
Participants: 16
Project status: SIGNED

MISSION-CCS presents a timely and unique doctoral network designed to deliver the next generation of highly trained researchers and entrepreneurs in the field of material science, specifically focused towards accelerating implementation of carbon capture and storage CCS technologies worldwide and ensuring the sustainable and safe operation of existing and future CCS systems. The training network combines unique experimental system design and modelling approaches, state-of-the-art analytical technologies and techno-economic analysis to deliver a new generation of researchers and entrepreneurs. The programme of research training centres of delivering Doctoral Candidate Researchers (DCRs) with world-leading technical expertise in material science and engineering relevant to the entire CCS process. MISSION-CCS ensures that the subject-specific technical knowledge of each DCRs is under-pinned by inter-sectorial knowledge whilst also promoting wider innovation skills and relevant training on the techno-economics of CCS, developing experts with breadth of knowledge. A central aim of the network is to forge a strong cohort culture, by ensuring that peer-to-peer learning and mutual support become the norm, in order to enhance experience. Research-led training activities are strengthened through a dynamic and interactive education based programme delivered by an internationally renowned consortium of academics and industrialists with complementary skills. As part of the training programme, subsequent to an introduction to CCS systems and the specific material science challenges, DCRs will gain knowledge of system design and optimisation, state-of-the-art analytical methods, theoretical modelling, techno-economics, and understand the challenges of exploiting their research. They will also acquire proficiency in project management, communication, entrepreneurship, and innovation; all essential attributes for any modern technical professional.

Keywords: corrosion,solvent degradation,geochemistry,mineral precipitation,carbon capture transportation,storage
Twinning for excellence in TEsting new generation PV: Long-term STAbility and field REliability (TESTARE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Cyprus,Belgium,Germany,Israel
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 1499996.25
EU funding (EUR): 1499996.25
Participants: 4
Project status: SIGNED

TESTARE aims to stimulate excellence and innovation capacity at the DegradationLab of University of Cyprus (UCY) in the topic of new generation PV technologies from the perspective of long-term stability and field reliability testing. To this end, UCY will link effectively with internationally-leading research institutions, namely Interuniversity Microelectronics Centre (IMEC), Fraunhofer Institute for Solar Energy Systems (Fraunhofer), and Ben-Gurion University (BGU). The project is put in place in order to bring UCY up to par with such excellence-intensive institutions by overcoming its weak points (lack of critical mass of scientists, networking, advanced metrology technical skills) to take its work on emerging PV testing to the next level. Activities will include knowledge transfer, exchange of best practices between UCY and leading partners, industrial networking, infrastructure sharing. The knowledge transfer will be achieved through in person training, staff/student exchanges, webinars, thematic workshops, and PhD scientific schools. To demonstrate the value of the twinning exercise and at strengthen the engagement of the partners, an exploratory research project will also take place to assess the performance and lifetime of perovskite on silicon tandem modules. This will entail close interactions between the partners including round-robin test campaigns and inter-comparison measurements towards developing new test and aging protocols for this technology. TESTARE will also focus on enhancing research management and administration capabilities at UCY in order to improve and make more sustainable its research ecosystem. This project will entail benefits for all institutions involved including the leading partners who will also gain access to new markets in MENA region. TESTARE is expected to lead to long-term ties between partners on joint proposals and projects, joint PhDs, infrastructure sharing, innovation, all of which will enhance the R&I system of Cyprus.

Keywords: perovskite,tandems,outdoor stability,field reliability
Reviving Empire: French and Spanish Visions of Imperial Renewal in the Greater Caribbean (1800-1830) (REVIVEMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

This project investigates Spanish and French visions of imperial renewal in the Greater Caribbean during the early nineteenth century, a time of profound crisis and spatial disintegration for both empires in the region. It posits that this first wave of decolonization inspired projects (both abortive and actualized) to reform imperial power in existing colonies, reverse the tide of independence movements, or expand the empire into new spaces. This project’s methodological approach combines a micro-historical perspective along with the transimperial and transnational framework of analysis adopted by global history. Using a comparative and connected perspective, it will focus on distinct yet interrelated modes of imperial revival ([1] commercial improvement, [2] colonization and resettlement, [3] reconquest and pacification) as reaction to decolonization. By examining a range of proposals for revitalizing and reterritorializing the Spanish and French empires in the Greater Caribbean, with an emphasis on the prominent role of colonial exiles, this project challenges narratives of inevitable imperial collapse and linear transition from empires to nation-states, and from formal to informal imperialism. It delivers new insights on imperial actors as active agents of transformations that impacted the Atlantic world during the nineteenth century. This project’s reappraisal of the resilience of imperial power and imaginaries in a (post)revolutionary context will be achieved by retrieving archival materials from a dozen locations across Spain, France, Cuba, and Mexico. This project will be hosted at the École des Hautes Études en Sciences Sociales (School for Advanced Studies in the Social Sciences) and conducted under the supervision of professor Clément Thibaud.

Keywords: imperial history,spanish and french empires,greater caribbean,19th century,comparative and connected history,decolonization
Feedback-control of the Microenvironment: Modular Organ-on-Chip Technology to elucidate the role of Neurovascular Stress in Schizophrenia (CHIPzophrenia)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

A well-controlled microenvironment is paramount for reproducible biomolecular studies. Organs-on-chips are in-vitro cell culture systems that employ microfluidic and biomaterial engineering towards that goal. They combine the advantages of animal models (physiological environment) with those of plastic-dish culture (human cells), and thereby hold exceptional promise in unraveling the biological processes that underlie health and disease. Yet control over the biochemical environment remains poor. With CHIPzophrenia, I propose to develop a new generation of organ-chip, one that features feedback-enabled control of the biochemical environment. I aim to realize dynamic and well-controlled application of stable therapeutics (via feedback sensors and flow control), and crucially also of highly volatile oxygen/nitrogen stressors by relying on electrochemistry to generate them in situ. My goal is to moreover implement a highly functional modular architecture so that the system can easily be repurposed and sensor/control modules reused – all with negligible dead volumes and displacement (key challenges in current organ-chips towards novel functionalities). I intend to leverage this organ-chip to elucidate how nitrosative stressors disrupt the complex multicellular interactions of the blood-brain barrier, where existing in-vitro models fail to provide the requisite cellular and chemical microenvironment. Yet such disruption is implicated in a wide array of disorders – including schizophrenia, where our biological understanding remains poor and in-vivo models are uniquely challenging. I will specifically test the hypothesis that nitrosative dysregulation of perivascular cells plays a causative role in neuronal dysfunction associated with the disorder. Not only will CHIPzophrenia thus reveal new potential treatment targets, but it will also establish the platform as a transformative tool for dynamic and well-controlled in-vitro research into stress-related disorders and beyond.

Keywords: organs on chips microfluidics reactive oxygen and nitrogen species feedback control blood brain barrier schizophrenia
Low and very-low-field 3D magnetic resonance spirometry for advanced regional exploration of respiratory diseases (V-LF-Spiro3D)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Germany,Netherlands,United Kingdom
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 3584656.75
EU funding (EUR): 3584656.75
Participants: 16
Project status: SIGNED

Lung function is a central concern in the fight against covid-19. Beyond the pandemic heavy losses and long-term health implications, respiratory diseases represent a major threat for the World Health Organisation. It is one of the leading causes of death worldwide, associated to our way of living and impacting all of society. Current tools for diagnosing and monitoring pulmonary conditions are hindered by poor sensitivity (lung function tests), radiation exposure (computed tomography) or examination cost (magnetic resonance imaging, MRI). They all differently fail to fully assess lung structure and function V|LF-Spiro3D aims at democratizing newly developed and breakthrough 3D MR spirometry with high performance, low-cost MRI techniques to provide a ten-minute morphofunctional MRI protocol to engage patients in a safer, easier and more comfortable way. Based on recent works at Universities Paris-Saclay and Aberdeen, in collaboration with leading MR manufacturer Siemens, SME NMR Service, major French-Dutch hospitals and patient organisations, V|LF-Spiro3D brings together multidisciplinary experts in a patient-oriented approach for both adults and children V|LF-Spiro3D will redesign current MRI architecture to perform 3D MR spirometry at low and very low field. High-performance MRI hardware will be developed with accelerated acquisitions and coupled reconstruction strategies relying on deep learning. Biomechanical lung modelling and deep data processing will be guided by implementation of 3D MR spirometry in clinical facilities to produce unprecedentedly large sets of normative and training data covering six major respiratory diseases By prioritizing both technology transfer and innovation, V|LF-Spiro3D aims to build up a one-stop-shop imaging standard for unrestricted assessment of lung pathophysiology. The impacts are expected to yield benefits beyond lung imaging and boost health deep-tech on point-of-care imaging and multi-parameter-based digital health in the EU

Keywords: lung diseases asthma bronchopulmonary dysplasia cystic fibrosis chronic obstructive pulmonary bronchiolitis disease obliterans syndrome biomechanics modelling low field mri 3d pulmonary function test