Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Systems-level novel understanding of anti-glycan immunity (SNUGly)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1993750.0
EU funding (EUR): 1993750.0
Participants: 1
Project status: SIGNED

Intestinal bacteria have an enormous influence on health, both in the form of major pathogens and as major constituents of the microbiota. We have demonstrated that high-affinity secretory antibodies (sIgA) offer huge potential to protect from infection and to manipulate microbiota composition. However, designing good oral vaccines to induce high-affinity sIgA is a compound problem. Most protective anti-bacterial sIgA targets bacterial glycans, requiring an understanding of inherently difficult glycan biochemistry. We also need to deliver intact antigen via the highly degradative environment of the intestine. Whole-cell inactivated oral vaccines can induce high-affinity sIgA against some glycan structures, but we have an incomplete picture of what determines the success/failure of these vaccines. By combining advanced biophysical methods (e.g. atomic force spectroscopy), fluorescence and electron microscopy, and synthetic biology, we aim to remove this mystery. Our objectives are: 1) Generate a "toolbox" for glycan-binding antibody research: Recombinant antibodies, BCR knock-in mice and defined glycan antigens as purified molecules, on whole bacteria or on virus-like particle will be developed for model antigens: Salmonella Typhimurium O-antigen and the E.coli K100 capsule. 2) Determine the quantitative relationship between glycan antigen sampling into gut-associated lymphoid tissues and particle size, glycan flexibility/structure, digestion resistance and natural IgA binding. 3) Determine how biophysical properties of glycan antigens affect B cell antigen uptake, T cell help and antibody affinity maturation. 4) Combine models of antigen sampling efficiency and anti-glycan antibody affinity maturation to generate a systems-level model of mucosal vaccine efficacy. This will uncover the fundamental principles governing the induction of high-affinity anti-glycan sIgA, driving urgently required progress in mucosal vaccine design

Keywords: mucosal antibodies,oral vaccines,b cell activation,glycoconjugate vaccines
Digital Enterprise Innovations for Bioimaging, Biosensing and Biobanking Industries (DIGI-B-CUBE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Germany,Belgium,Norway,Greece,Portugal
Call: Cluster facilitated projects for new industrial value chains (H2020-INNOSUP-2018-01-two-stage, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 5103161.92
EU funding (EUR): 4989000.0
Participants: 9
Project status: CLOSED

DIGI-B-CUBE project aims to unlock the cross-sectoral collaborative potential of SMEs by combining Artificial Intelligence (AI), Cognitive Computing Digital Technologies (CCDT) with the Bioimaging-Biosensing-Biobanking (B-CUBE) and realted industries to deliver market sensitive disruptive technologies and generating innovative solutions that enhance patient-centred diagnostic work-flows, delivered through the improved algorithms for Medical Diagnostics’ efficiency and accuracy. DIGI-B-CUBE will study the characteristics in market dynamics & specificities for innovations created by merging AI, CCDT & B-CUBE and realted industries. By providing a framework for a more structured cross-sectoral and cross-border collaboration, that manages all the complex work-flows within the process, DIGI-B-CUBE instantiates the mechanisms to ensure the long-term sustainability of the action through collaborations of the participating clusters with hospitals, academia, industry, investors, business angels, managing authorities of the national innovation agencies and the European Commission support measures (such as EIT, ESIF). The main objective of this project is to provide key digital solutions for the reconfiguration of the Medical Diagnostics and related value chains towards a Health Economy 4.0 with a special focus on Biobanking, Bioimaging and Biosensing and realted industries. Activities financed by the ESIF in the participating regions as part of the Smart Specialisation Strategies will be bundled in cooperation with the responsible managing authorities in addition to the innovation voucher scheme for SMEs. By integrating innovations in IT into Bioimaging, Biosensing and Biobanking and realted industries, this project will accelerate the goal of personalised medicine that can eventually offer patients with fast and efficient diagnosis-treatment-healthcare system.

Keywords: medical diagnostics value chain,cross sectoral digital innovation,health,sme growth
Pilot Application in Urban Landscapes - Towards integrated city observatories for greenhouse gases (PAUL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Green Deal challenges
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Italy,Germany,Italy,Italy,Switzerland,Switzerland,Belgium,Finland,Poland,Sweden,Switzerland,Greece,Norway,France,France,Czechia,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: European Research Infrastructures capacities and services to address European Green Deal challenges (H2020-LC-GD-2020-6, 2020)
Start date: 2021-10-01
End date: 2025-12-31
Duration (months): 51.0
Total project cost (EUR): 12999999.0
EU funding (EUR): 12999999.0
Participants: 39
Project status: SIGNED

The "Pilot Application in Urban Landscapes - Towards integrated city observatories for greenhouse gases" (PAUL) project supports the European Green Deal by creating capabilities to observe and verify greenhouse gas emissions from densely populated urban areas across Europe. Cities are recognized as important anthropogenic greenhouse gas emission hotspots and therefore play a significant role in any emission reduction efforts. The PAUL project aims to increase our understanding of specific needs of greenhouse gas emission assessment in urban environments; it compares available and novel observational approaches and implements an integrated concept for a city observatory, providing unique data sets that feed diverse modelling approaches, scientific studies and will be the base of services towards the city administrations. A specifically innovative approach is the co-design of services, models and observations between city administrators and scientists from multiple disciplines including social and governmental sciences.The PAUL co-design approach will explore the needs of the cities and combine these with the scientific outcomes. This allows to introduce smart services to the cities, supporting evidence-based decisions on climate action and strategic investments. Overarching goals of PAUL are to: 1) implement elements of a pilot city observatory in a large (Paris), a medium (Munich) and a small (Zurich) European city, 2) collaborate with city stakeholders and engage citizens in co-designing services that are required for GHG monitoring in order to validate the implementation of Paris Agreement, and 3) increase our understanding of specific needs of GHG assessment in urban environments and create a service portfolio for setting up an urban greenhouse gas observatory.

Keywords: climate action plans,co designed services
Illuminating Ultra-Slow Spreading Centres: a seismic approach to the Cayman Trough (CAYMAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

About 25% of the Earth’s mid-ocean ridges spread at ultraslow rates of less than 20 mm/yr. However, most of these ultraslow spreading ridges are located in geographically remote areas, which hamper investigation. Consequently, how the crust forms and ages at such spreading centres, which traditional models predict to be magma-starved and cold, remains poorly understood. Recent studies of the ultraslow Mid-Cayman Spreading Centre in the Caribbean Sea, have observed the deepest and hottest black smoker hydrothermal systems on Earth, and off-axis medium-temperature venting with exhumed lower crustal and upper mantle and volcanic lithologies juxtaposed by detachment-style faulting. In CAYMAN we will establish the lithospheric context of these observations that contradict the predictions of traditional models, and test recently developed models of oceanic crustal formation at the slowest of spreading rates. We will use for the first time closely-spaced stations for a high-resolution subsurface mapping of seismic velocities to study the temporal and spatial interplay between magmatic accretion and magmatic tectonic extension, and the controls on and relationship between faulting and hydrothermal activity. The project scope is centred on the growing body of evidence that crust accreted at slower spreading rates does not form by a simple process of symmetric, magmatic accretion as traditional models predict. Instead tectonic extension accommodated by large-offset detachment faults, along which water percolates and by which the lower crust and the serpentined upper mantle are exhumed, appears to play a significant role. CAYMAN is an innovative project that will provide a quality leap in the understanding of ultra-slow spreading centres. It has a strong international dimension, and will deliver several high-profile publications, providing unique training and career development opportunities for the Experienced Researcher.

Keywords: spreading centres,ocean core complexes,magmatic accretion
Spin-Delocalization with a Twist: Chiral Open-Shell Helices (INSPIRAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1499925.0
EU funding (EUR): 1499925.0
Participants: 2
Project status: CLOSED

Spin-delocalization in molecules containing unpaired electrons gives rise to an unusual intermolecular interaction, named as pancake bond. This bonding interaction couples unpaired electrons between multiple pairs of atoms from each face-to-face oriented spin units, such as phenalenyl radical, and abets formation of assemblies that display large antiferromagnetic interaction in the solid state. This phenomenon governs the potential use of such spin systems as molecular conductors, magneto-optical bistable materials, or molecular spin batteries. Formation of such assemblies during crystallization is spontaneous. It is therefore difficult to control and tune the antiferromagnetic interaction, which dictates the electronic properties of the solid material. Inspired by this challenge, the goal of this project is to develop systems, where the spin-interaction can be tuned within a single molecule to understand principles that govern an intermolecular assembly in the solid state and the bulk properties. To achieve this goal, I propose to synthesize and study chiral open-shell helices, in which the intramolecular spin-interaction can be tuned by varying (1) the coupling mode, ferromagnetic versus antiferromagnetic, and (2) its strength. The helical character of these systems enables tuning of the coupling strength by control of the degree of overlap and distance between the spin units, which is difficult to achieve by a spontaneous assembly. Additionally, it provides access to both racemic and enantiopure solid-state architectures that can further impact the properties. Two model systems will be investigated: one in which spins communicate simultaneously through backbone and space, and one where spins communicate only through space. Understanding the principles of spin-interactions in these helical systems is of fundamental interest for designing molecules with tailor-made properties, as well as features that arise unexpectedly from the interplay of the spins in a spiral.
Megacity Aerosol Composition by Satellite: A tool to study anthropogenic Emissions, Climate change and human Health (MACSECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-15
End date: 2024-02-13
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Anthropogenic aerosol emissions from growing urban agglomerations contribute to air pollution with impacts on climate change and on human health. The composition of aerosols over megacities is partly unknown, although important to accurately understand and prevent these impacts. Satellite-based remote sensing provides a unique opportunity to spatially monitor the atmospheric composition in the lowermost troposphere. We propose to analyze complementary information on gases and aerosols in order to provide estimates of aerosol concentration at the surface with their composition, specifically over megacity regions. Current aerosol concentration and chemical composition will be assessed by combining: 1) Local snapshots of aerosol concentration and composition at high spatio-temporal resolution from aircraft campaigns, 2) Global retrievals of aerosol optical properties from satellite measurements, and 3) Numerical atmospheric simulations. This project focuses on three regions (with different emission regulations) where scientific aircraft campaigns have been carried out, namely Europe (strict regulation), East Asia (regulation implementation in progress) and West Africa (no regulation). Based on modelling sensitivity studies, we will evaluate the benefits of emission reduction strategies on human health and anthropogenic climate change. Applied to future regulations, our methodology will provide a comprehensive analysis to advise policymakers on sustainable choices.

Keywords: megacity,aerosol,air quality,atmospheric composition,health impact,remote sensing,numerical,modelling
Decouple Electrochemical Reduction of Carbon Dioxide to High Value Products (DeCO-HVP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 1499994.0
EU funding (EUR): 1499994.0
Participants: 1
Project status: SIGNED

This programme aims to convert carbon dioxide into high value hydrocarbon products using carbon neutral electrochemical methods. High value products are materials that may be used as carbon based chemical feedstocks and as synthetic fuels, reducing the ever-present demand on oil and natural gas to fulfil these needs. The project is within the remit of an international ambition to valorise carbon dioxide waste and reduce environmentally harmful greenhouse gas generation, as opposed to stopping at carbon capture and sequestration. This proposal outlines an alternative route to carbon dioxide utilisation (CDU), in which a mediated approach that decouples the electrochemical reduction from the catalytic process is explored. Novel bimetallic catalysts will be synthesised and studied, meditating electron donating solutions will be generated, and a robust and comprehensive analytical arrangement will be implemented to allow total identification and quantification of the wide range of possible products. Electrocatalytic CO2 reduction is one of the key approaches to CDU, as it has a direct pathway to carbon neutral renewable electricity. Nonetheless it is a field that has shown minimal progress in the past 30 years. A paradigm shift is necessary in the approach to electrochemical CO2 reduction, where conventional heterogeneous interfacial catalysis is limited by mass transport, passivation, and CO2 solubility. This proposal outlines the use of electron donating mediators generated separately to the catalysed chemical reduction of CO2, such that the electrolyte becomes the electrode. This opens a whole new avenue for catalyst research, and here target bimetallic catalysts that suppress side reactions and promote high value product synthesis are described.
Adaptive learning platform for personalized children education crossing cognitive and biometric inputs (Infantium 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 1483288.8
EU funding (EUR): 1038302.0
Participants: 1
Project status: CLOSED

The current educational system is not optimal - arguably even obsolete. At Infantium we are committed to bringing the latest advances in information and communication technologies to education in order to fundamentally change how our children learn. Our proposed solution is an intelligent framework that gathers cognitive information related to the performance and interaction of kids as they consume educational content (such as APPs, learning videos, etc.) on tablets. The software monitors parameters such as the time required for a child to reach certain goals within the APP, or the time between two consecutive interactions in order to develop cognitive models. Moreover, we monitor users’ biometric parameters using a bracelet device and a standard tablet camera to infer students’ emotions and gather behavioural information. Our main objective is to fuse cognitive and behavioural data, using our Artificial Intelligence-based technology. The result will be a unique system that is able to maximize learning ability using cognitive abilities and emotional motivation. We are applying for funding through this program specifically to 1) miniaturize the bracelet prototype for comfort and ease of use, 2) modify and test the computer vision software with kids, using tablets, 3) fine-tune our algorithms to infer emotional states, 4) correlate the data from the wearable device and the vision algorithm, and 5) test the integrated system with kids during early childhood education. We are requesting about € 1.5M that will allow us to boost our growth by 45%, achieving an additional sales revenues of € 11M and representing a ROI of 4 by 2020.

Keywords: adaptive learning,artificial intelligence,cognitive neuroscience,affective neuroscience,neural networks,wearables,sensors,computer vision,sensor fusion,distributed wireless networks
Sexually dimorphic neuronal circuits underlying social behaviours in Drosophila (sexual dimorphism)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 2
Project status: CLOSED

Sex differences are basic for reproduction, parenting and other social interactions. Pheromone secretions that are differentially perceived by males and females, release stereotypical behaviours in many species. I will study how simple connectivity switches in a Drosophila sexually-dimorphic neuronal circuit are assembled into complex networks, from sensory processing to behavioural control. 11-cis-Vaccenyl-acetate (cVA) is a male-pheromone eliciting sex-specific responses: attracts females and repels males. Sex-specific wiring of olfactory neurons reroutes cVA information, forming a developmental switch in information flow. Central aSP-g neurons receive cVA innervation in females but not males, while this cluster is implicated in male-male aggressive behaviour. The role of aSP-g in social interactions was not compared between sexes, and that is my first aim. Next, I will find input and output neurons of aSP-g neurons in both sexes, by combining state-of-the-art anatomical, physiological and behavioural methodology: in-silico circuit-tracing methods to find neurons with overlapping innervations to aSP-g; and a unique electron-microscopy volume scan of a female brain to reconstruct aSP-g neurons and their synaptic partners. I will validate functional connectivity using photoactivation of output neurons while calcium-imaging target neurons. I aim to discover how sexually-specific wiring differences in homologous circuits regulate sexually-dimorphic social behaviours. These basic neuronal connectivity motifs may be conserved beyond flies.

Keywords: drosophila neurogenetics,sexually dimorphic behaviours,sexually dimorphic neural circuit,lateral horn,pheromone