Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hyperconnected simulation ecosystem supporting probabilistic design and predictive manufacturing of next generation aircraft structures (CAELESTIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Spain,Finland,France,Sweden,Austria,Netherlands,Cyprus,Germany
Call: Next generation digital aircraft transformation in design, manufacturing, integration and maintenance (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 5956882.75
EU funding (EUR): 5956880.0
Participants: 13
Project status: SIGNED

CAELESTIS will develop an end-to-end Interoperable Simulation Ecosystem (ISE) that will perform multidirectional dataflow across the aircraft value chain linking product design and distributed engineering teams´ CAD-CAE tools, to accelerate the design and engineering optimization of disruptive aircraft and engine configurations, ensuring their manufacturability from the design conceptualization. CAELESTIS ecosystem will be developed to integrate, interoperate, and autonomously execute simulation workflows involving a variety of state-of-the-art simulation tools to support the multi-disciplinary design, optimisation as well as uncertainty quantification and propagation across the design and manufacturing chain. The ecosystem will be boosted by HPC infrastructures to massively execute predictions and deliver optimized design and engineering outputs at realistic-time scales. In this regard, high-fidelity model-based digital twins with unprecedented level of detail and covering several production stages and manufacturing deviations will be developed and interconnected. Those will be linked to machine learning tools adapted to HPC simulation outputs to improve detection of manufacturing flaws based on a probabilistic approach to quantify uncertainties and their propagation and influence on structural integrity, as well as identify design for manufacturing interdependencies to provide optimized product topologies. From manufacturing point of view, HPC simulations will be made available at manufacturing shopfloor as reduced order models in online monitoring edge computing devices, to support i) product performance prediction based on detected defects on real time and ii) informed corrective actions to minimize and compensate their effect. Overall, CAELESTIS ISE will contribute to generate optimized and reliable aircraft design configurations, widen the design space and optimize the manufacturing process window and improve production efficiency and inline quality assurance.

Keywords: interoperability,digital twins,simulation workflows,cad cae,uncertainty quantification and propagation,manufacturing defects,high performance computing,machine learning,edge computing
Using lake sediments to reconstruct soil weathering trajectories over the Holocene (LAKE-SWITCH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1494788.0
EU funding (EUR): 1494788.0
Participants: 1
Project status: SIGNED

Chemical weathering is a central biogeochemical process that shapes the Earth’s Critical Zone (CZ), regulates the global carbon cycle and sets the pace for nutrient delivery to soils and ecosystems. Most knowledge on the rates and controls on chemical weathering are from laboratory experiments and from the short-term observation of modern soil and river systems. In contrast, little is known about past changes of chemical weathering over hundreds to thousands of years, which limits our understanding of how long-lasting human-climate-ecosystem interactions have impacted the CZ trajectories. Because of this knowledge gap, it is not possible to fully understand the response and feedbacks of the CZ to the climatic and environmental perturbations of the Holocene period, nor to predict their future evolution during the Anthropocene. To fill this gap, LAKE-SWITCH aims to produce new quantitative weathering records over 10^2-10^4 year timescales, with a temporal focus on the Holocene period. There are 3 main challenges: 1) developing quantitative proxies of chemical weathering, 2) calibrating these proxies for paleo-reconstructions, 3) measuring these proxies in paleo-archives of 10^2-10^4 year timescale integration. To provide these records, we will measure lithium and strontium isotopic proxies in lake detrital and authigenic – carbonates and biogenic silica – sediment archives. To calibrate these proxies and archives, we will use a source-to-sink approach and track weathering product pathways from soils, through rivers, to lake deposits. Then we will apply these proxies back in time in Holocene lake cores. As rapidly-eroding mountain dominate the global chemical erosion budget, we will focus on the study of the European Alps. New data from Alpine watersheds and lake records spanning gradients in erosion, runoff and land use will serve to quantify and model the impact of climate and human drivers on soil trajectories from the onset of the Holocene to the Anthropocene.

Keywords: critical zone,chemical weathering,lake records,holocene,carbonates
Cargo-towing Highly enantioselective Electro-pumps: unconventional asymmetrIc Readout and transmission of chiral information (CHEIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1492004.0
EU funding (EUR): 1492004.0
Participants: 1
Project status: SIGNED

Chirality is found throughout nature, but it occupies a special place in chemistry, perhaps for historical reasons, but mainly as a result of the beneficial properties of chiral molecules across a diverse range of areas, from medicine to materials science. The global aim of CHEIR is to achieve with unprecedented efficiency the propagation of chiral information along different length scales, based on the synergy of well-chosen molecular ingredients and physicochemical engineering. The artificial systems here involved can be considered as models for the transmission of chiral information through space. Such ambitious aim could be achieved developing a cargo-towing electro-pump based on chiral conducting polymers for targeted drug-delivery applications. The combination of four main ingredients, electric field and magnetic field (externally applied), electrical conductivity and enantiodiscrimination capability (intrinsic features of the object), makes these innovative miniaturized bipolar soft pumps perfect candidates for a multipurpose asymmetric detection. In such scenario inherent chirality can provide the breakthrough. It implies chirality and key functional properties to originate from the same structural element endowing the selector with extraordinary chirality manifestations that can be propagated from molecular level to the macroscopic one. Unprecedented recognition, in terms of energy differences, was recently observed, implementing inherently chiral materials as enantiopure electrode surfaces. Recently, attractive potentialities of these systems were also exploited in the field of bipolar electrochemistry and in the one of autonomous swimmers allowing to correlate the output signal with the concentration of the enantiomers present in solution. Such striking performance will prepare for the development of innovative systems with high impact in analytical, biological and pharmaceutical fields considering the project interdisciplinarity.

Keywords: inherent chirality,enantioselectivity,electro pumping systems,cargo towing systems,helical magneto swimmers,bipolar electrochemistry
Spontaneous interfacial oxidant formation as a key driver for aerosol oxidation (SOFA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2726588.0
EU funding (EUR): 2726588.0
Participants: 1
Project status: SIGNED

Aerosols and clouds are key players in tropospheric chemistry. These tiny particles suspended in the air, with a radius ranging from a few nanometres to tens of micrometres, impact atmospheric composition, represent one of the largest uncertainties in climatic projections and cause millions of deaths worldwide every year. Hence, they have enormous societal and economic consequences. Nonetheless, there is still a knowledge gap preventing us from describing the chemical evolution of aerosols and clouds during their atmospheric lifetime. Supported by preliminary experiments, I therefore propose to unravel the impact of the spontaneous oxidant formation at the air/liquid interface as a key driver for multiphase oxidation processes. Water molecules in bulk liquid are stable and inert under ambient conditions. In sharp contrast, it was very recently shown that the local orientation of water molecules at an air/water interface induces an electric field that generates spontaneous radicals in micron-sized droplets. This production does not involve any catalysts such as light or heat. It is an intrinsic property of the air/water interface, and therefore potentially ubiquitous in the troposphere. This spontaneous interfacial oxidant formation has never been explored for its atmospheric significance. Therefore, the SOFA project aims to unravel the atmospheric importance of this interfacial (dark) chemistry. If oxidants (including OH radicals) are in fact spontaneously produced at the air-water interface, under atmospherically relevant concentrations, this would profoundly challenge our understanding and description of atmospheric multiphase chemistry. SOFA will develop a novel strategy, scaling up from laboratory-based measurements to fieldwork and modelling to assess the importance of this interfacial chemistry. SOFA will advance an entirely new perspective on how to address the multiphase oxidation capacity of the troposphere, and will therefore have a wide impact.

Keywords: aerosol,cloud,interfacial chemistry,radicals,atmospheric oxidation capacity
Effects on Air quality of Semi-VOLatile Engine Emissions (EASVOLEE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Greece,France,Netherlands,Israel,Norway,Switzerland
Call: Prevent smog episodes in Europe: Air quality impact of engine-emitted volatile, semi volatile and secondary particles (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2999051.0
EU funding (EUR): 2999051.0
Participants: 8
Project status: SIGNED

The Effects on Air quality of Semi-VOLatile Engine Emissions (EASVOLEE) project brings together leading European research groups, with state-of the-art observational and modeling facilities to: i) Quantify the contributions of secondary aerosol formation from transport engines to air quality problems in Europe. ii) Develop and identify health-related metrics, mitigation strategies, and policies to improve air quality, limiting the concentrations of aerosol (organic, inorganic, nanoparticles). The project combines state-of-the art measurement of the complete suite of emissions of transport engines under real driving conditions, investigations of the formation of secondary particulate matter (PM) during their atmospheric processing, and studies of the toxicity of both the fresh and aged PM and of the mechanisms that affect health. These results will be used to improve chemical transport models that in turn will allow us to quantify the effects of engine emissions on air quality and health - both now and for a series of future scenarios. EASVOLEE will improve our understanding of organic emissions from vehicle exhaust including low-volatility (LVOCs), semi-volatile (SVOCs), intermediate volatility (IVOCs) and volatile organic compounds (VOCs). It will elucidate the corresponding secondary aerosol formation (both organic and inorganic) and characterize the health effects of these primary and secondary particles. The contribution of engine exhaust emissions to PM2.5 and size-resolved particle number concentrations in Europe will be quantified during all seasons. The above scientific evidence will be used to investigate the effectiveness of policies to reduce secondary organic and inorganic PM levels in urban areas – with a focus on components impacting health. Finally, EASVOLEE will develop new approaches to improve the quantification of transport impacts on air quality and health effects supporting future emissions and climate legislation.

Keywords: air quality semivolatile organics atmospheric chemistry health effects chemical transport modeling
Identifying the Fast-acting Antidepressant Signatures of Treatment Response with psychedelic compounds using a novel behavioral tracking system and single-cell resolution (FASTer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Mental health disorders affect 84 million people across Europe and are associated with an economic burden of €600 billion/year. New evidence from clinical trials suggests that a single treatment with psychedelic compounds, such as psilocybin, can produce a fast (hours) and sustained (months) antidepressant (AD) response. However, many questions still remain about its mechanism of action, due to methodological challenges such as lack of knowledge of the brain cells and circuits where AD effects are taking place and limitations of the behavioral tests used to examine AD activity in rodents. Combining molecular, behavioral and advanced computational tools, FASTer will establish a groundbreaking and automatic behavioral tracking system to deconstruct the behavioral “language” associated with treatment response. In addition, FASTer will identify the brain cells and circuits responsible for the fast-acting and sustained AD effects of psilocybin. This is a move away from the traditional assessment of single behavioral readouts to unconventional group behaviors and endophenotypes in a translationally-relevant context that will cause a paradigm shift and revolutionize the field of behavioral phenotyping. Thanks to my unique know-how in bridging human and pre-clinical psychiatry, and to go beyond the state-of-the-art, I will combine activity-dependent labelling techniques and single-cell methods to identify the genes and brain circuits engaged during psilocybin treatment. To address the multidimensional nature of psychiatric disorders, I will manipulate gene networks related to the AD effects of psilocybin. The ambitious and innovative studies proposed here have the potential to change our understanding of psychiatric disorders, and transform the field of behavioral neuroscience. Ultimately, FASTer holds tremendous promise for translatability of preclinical findings and impacting the development of fast-acting and efficacious treatments for psychiatric disorders.

Keywords: psychedelics,psilocybin,antidepressants,treatment response,animal models of stress and anxiety,fast acting antidepressant effects,neurobiological circuits,single cell resolution,translational psychiatry,behavioral tracking systems
Breeding European Legumes for Increased Sustainability (BELIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: France,United Kingdom,Spain,Netherlands,Germany,Denmark,Norway,Belgium,Serbia,Lithuania,Croatia,Portugal,Poland,Czechia,Italy,Switzerland,Bulgaria,Lebanon
Call: Boosting breeding for a sustainable, resilient and competitive European legume sector (HORIZON-CL6-2022-BIODIV-02-two-stage, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 7582527.2
EU funding (EUR): 7077914.74
Participants: 35
Project status: SIGNED

The aim of BELIS is (i) to increase the competitiveness of the EU and Associated Countries legume breeding industry by improving the methodologies and the governance structures of the breeding sector; (ii) to design conditions that allow an efficient delivery of the achieved genetic progress to the breeders and seed industry, and to the other actors (registration offices, extension services, feed and food industry, farmers). The project will focus on seven forage crops and seven grain crop that are currently grown to produce feed (for ruminants – cattle, sheep, goat and monogastric animals – pig, poultry), food (as is or after processing) or to deliver ecosystem services. BELIS has three main objectives: (1) To develop tools and methodologies for cost-effective breeding programmes and deliver proofs of concept, with and for breeders, (2) To facilitate the economic and regulatory environment: variety registration, variety recommendation and business models, (3) To implement an efficient, ambitious and durable transfer of innovation through the BELIS platform that includes a network of breeders and actors from scientific research, extension services and seed, food and feed industries, as well as a training portfolio. By enabling the creation of improved varieties in many species, adapted to different areas and uses in Europe, this project is relevant for the destinations towards “Biodiversity and Ecosystem Services”, mainly contributing to “Access to a wider range of crops and breeds with a broadened genetic base is improved in line with global biodiversity commitments”. It also supports the “Practices in agriculture and forestry support biodiversity and the provision of other ecosystems services”. In addition, BELIS will have a positive input on natural biodiversity, reduction of air and water pollutions and farming system sustainability.

Keywords: legume,phenotype,genotype,molecular breeding,variety registration,variety recommendation,business model,governance,training,platform,network,forage,food,grain,yield,pest,quality,drought
THE CARE WAVE AND THE FUTURE OF THE BABY BOOMERS AND THEIR CHILDREN (BB-Future)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Belgium,France,Spain,Canada,Germany,Netherlands
Call: Socio-economic effects of ageing societies (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2951569.75
EU funding (EUR): 2951569.75
Participants: 7
Project status: SIGNED

The baby boomers are in the process of retiring. Most are between 60 and 65 when they retire and almost 80% self-assess their health as good. A huge number of research projects has analyzed retirement decisions and the impact of this “pension wave” on the transformation of pension systems in the ageing societies in Europe and elsewhere. There is no lack of pension finance projections and policy advice for pension reforms and their socio-economic effects, including active ageing and the role of elder citizens in transforming our economies into “silver economies”. Much less is known about the second great transformation that will follow the pension wave. In the mid2030s, the health of the baby boomers will have deteriorated and many in these large cohorts will be in need of formal and/or informal long-term care. This “care wave” will transform two generations: the baby boomers in need of care and their children who may supply care. It will have significant implications for labour supply, especially for women, saving behaviour, and therefore for productivity, economic growth and its inclusiveness. The overarching objective of BB-Future is to make a concerted effort to understand the size and the implications of the care wave on economic and social outcomes, to appreciate the quality of this second ageing-related transformation and to develop policy recommendations for advance planning on the EU and MS levels.

Keywords: long term care,female labour force participation,inclusive growth,intra intergenerational equity