Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Application of new technologies and methods in nutrition research – the example of phenotypic flexibility (NUTRITECH)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Netherlands,Germany,United Kingdom,Norway,Netherlands,Ireland,Bulgaria,France,Italy,Spain,Belgium,Austria,Canada,Australia,New Zealand,Spain,United States,Germany,Hungary,Italy
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2016-06-30
Duration (months): 54.0
Total project cost (EUR): 7841178.32
EU funding (EUR): 5986490.0
Participants: 24
Project status: CLOSED

NutriTech will build on the foundations of traditional human nutrition research using cutting-edge analytical technologies and methods to comprehensively evaluate the diet-health relationship and critically assess their usefulness for the future of nutrition research and human well-being. Technologies include genomics, transcriptomics, proteomics, metabolomics, laser scanning cytometry, NMR based lipoprotein profiling and advanced imaging by MRI/MRS. All methods will be applied in an integrated manner to quantify the effect of diet on “phenotypic flexibility”, based on metabolic flexibility (the capacity for the organism to adapt fuel oxidation to fuel availability). However, NutriTech will move beyond the state-of-the-art by applying these integrated methods to assess the underlying and related cell biological and genetic mechanisms and multiple physiological processes of adaptation when homeostasis is challenged. Methods will in the first instance be evaluated within a human intervention study, and the resulting optimal methods will be validated in a number of existing cohorts against established endpoints. NutriTech will disseminate the harmonised and integrated technologies on a global scale by a large academic network including 6 non-EU partners and by providing an integrated and standardised data storage and evaluation platform. The impact of NutriTech will be multifold and exploitation is crucial as major breakthroughs from our technology and research are expected. This will be achieved by collaboration with a consortium of 8 major food industries and by exploitation of specific technologies by our 6 SME partners. Overall, NutriTech will lay the foundations for successful integration of emerging technologies intro nutrition research.

Keywords: technology nutrigenomics nutrition method
Products from methanol by synthetic cell factories (PROMYSE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Norway,Switzerland,Germany,Netherlands,France,Germany,Germany,Germany
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 3876091.4
EU funding (EUR): 2968759.0
Participants: 10
Project status: CLOSED

There is a high societal need for a sustainable production of key chemistry, food and health care compounds. Microbial cell factories are logical production systems, but up to now they use sugars and other food derived raw materials as substrates. Sugars originating from plants demand cultivable land which is more and more needed for human nutrition. Methanol - with a worldwide production capacity of more than 46 million tons per year - is regarded as an alternative highly attractive raw material in microbial fermentation for the manufacturing of special, fine, bulk, and fuel chemicals. This is especially true for the EU market, where industrial biotechnology still is hampered by strict use and price regulations as well as import limitations for agricultural commodities, such as corn or sugar. The supply of methanol can base upon both fossil and renewable resources, rendering it a highly flexible and sustainable raw material. Our vision is a viable methanol-based European bio-economy, which we will promote by for the first time applying synthetic biology principles for cell factory development in order to harness methanol as a general feedstock for the manufacturing of special and fine chemicals. In nature, methylotrophic microorganisms can utilize methanol as their sole source of carbon and energy. The project PROMYSE will deliver an alternative route to sought-after chemicals, with a major focus on terpenoids. PROMYSE combines two frontline research topics: orthogonal modularization of methylotrophy within a Synthetic Biology concept and employing methanol as a feedstock for biotechnological production. Through the transfer of methylotrophy modules, Synthetic Biology will pave the way to capitalize on the metabolic versatility and engineered production pathways of genetically well tractable microorganisms, such as E. coli, B. subtilis and C. glutamicum for biotransformation from methanol.

Keywords: methanol,methylotrophy,orthogonality,cell factories,fine chemicals,terpenoids,industrial biotechnology,systems biology,synthetic biology,metabolic engineering,directed evolution
Strategies for the eradication and containment of the invasive pests Rhynchophorus ferrugineus Olivier and Paysandisia archon Burmeister (PALM PROTECT)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: United Kingdom,Israel,Spain,Spain,Spain,Greece,France,Italy,Italy,Slovenia,Egypt,Spain
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 3971722.8
EU funding (EUR): 2999419.0
Participants: 13
Project status: CLOSED

The PALM PROTECT consortium aims to develop reliable methods, for use by national plant protection organisations (NPPO), inspection services, growers and other end-users, for early detection, eradication, control and containment of the red palm weevil, Rhynchophorus ferrugineus and the moth Paysandisia archon. The methods will be developed for use at origin, point of entry, in transit and on-site to combat these invasive pests of palm trees. The methods will support stakeholders and end-users in the implementation of Council Directives 2000/29/EC, 2007/365/EC, 2008/776/EC, 2009/7/EC and 2010/467/EU. The objectives identified to achieve these goals are: 1) to provide a more comprehensive understanding of the biology (life cycles, host range, capacity for dispersal, behaviour) of R. ferrugineus and P. archon to facilitate decision making for risk assessment and optimisation of monitoring and control methods. 2) To combat the spread and establishment of R. ferrugineus and P. archon by the development of technologies for the early detection and monitoring of these pests. Detection in quarantine areas using dogs, acoustic and thermal methods, and in open areas using trapping and aerial/satellite imaging, along with a decision support system 3) To develop methods to eradicate, control and contain R. ferrugineus and P. archon, to restrict their further invasion of EU territories. Scientifically based protocols will be developed for quarantine treatments, for eradication and containment including preventive and curative techniques, and proper disposal of infested material. 4) To disseminate the findings of this work both within and outside the EU Community, through working with NPPOs, the European Plant Protection Organisation (EPPO) and other stakeholders. PALM PROTECT will address gaps in current technology for the detection, eradication and containment of R. ferrugineus and P. archon, thereby helping to minimise the economic and environmental impact of these pests.

Keywords: palm,ipm,biological control,push-pull,mass trapping,attract-and-infect,risk assessment
NPlast - A neuroscience school that aims to preserve and restore neuroplasticity in brain disorders (NPLAST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,France,Netherlands,United Kingdom,Switzerland,Germany,Belgium
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 3954679.0
EU funding (EUR): 3954679.0
Participants: 10
Project status: CLOSED

Brain disorders impose an increasing economical and social burden in the member states of the European Union (EU). For most neurodegenerative diseases and many neuropsychiatric disorders no efficient treatment is available and no cure exists. In the next coming years the number of particularly elderly people suffering from brain disorders will tremendously increase. Predictions from the turn of the century about the exponential increase of dementia patients turned out to be correct and Alzheimer’s disease alone is underway to become the most expensive and most pressing health problem in the EU. The complexity of these diseases requires a more integrative view of the multiple interactions between genes and environment, synaptic processes and neuronal cicuitry. This is, however, not only achieved by training more young scientists in the relevant disciplines. The plastic properties of the brain can only be exploited by scientists that are trained to deal with this complexity and that are familiar with state of the art technology as well as with the principles at different levels of analysis. In consequence it is advisable for a training network to study more than one disease and to train scientists with a wide range of skills and background knowledge. The NPlast consortium consists of four partners from the private and seven partners from the public sector and will provide a research training program for fifteen young scientists. The program covers a broad spectrum of disorders and interventions ranging from synaptopathies and trafficking deficiencies to Alzheimer’s disease, and from altering gene expression programs to manipulations of the extracellular matrix of the brain to preserve or restore synaptic function. The key objective of the NPlast training network is to investigate neuroplastic principles that can preserve or restore function and that can be used to ‚rejuvenitate’ the brain in the elderly as well as to treat neuropsychiatric conditions in adults.

Keywords: health sciences,brain disorders,neuroplasticity,synapse,proteomics,integrative neuroscience,neural networks,super-resolution microscopy,systems biology,synapse-to-nucleus signaling,behaviour
Translational Training network on the Cellular and Molecular Bases of Heart Homeostasis and Repair (CARDIONET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Netherlands,United Kingdom,France,Germany,United Kingdom,Spain,Germany,Sweden,Germany
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 4501783.38
EU funding (EUR): 4501783.38
Participants: 12
Project status: CLOSED

The CardioNeT Initial Training Network aims to implement a highly multidisciplinary, intersectoral and competitive training programme in cardiovascular research through cutting-edge projects and extensive training in complementary areas. CardioNeT training comprises two tightly linked components - research and complementary training - that will be implemented at local as well as network level and which will be united by individual personal career development plans carefully elaborated for each researcher recruited. The training will be complemented by intersectoral secondment opportunities offered by industrial and academic partners. Research training • Theoretical and technical local training by the different network partners, integrating knowledge from holistic molecular and cellular biology approaches with the aim to better understand the regulation of heart development and disease and to provide novel therapeutic alternatives • A variety of Network courses and workshops providing theoretical and practical training, from bioinformatics to advanced non-invasive imaging Complementary training • Complementary skills acquired through participation in local PhD programmes • A range of different activities covering various aspects of complementary training, from presentation skills, to grant applications, management, IPR and Science & Society courses. The programme will be implemented by a network consortium comprising eleven partners from both the public and industrial sectors which is further enhanced by the participation of two associated partners. Researchers who participate in the CardioNeT training programme will benefit from a significant improvement of their career prospects that will be further strengthened by the trans-national and trans-sectoral collaborations that are the basis of this network.

Keywords: health sciences
COMPREHENSIVE APPROACH TO ENHANCE QUALITY AND SAFETY OF READY TO EAT FRESH PRODUCTS (QUAFETY)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Italy,Greece,Portugal,Israel,United Kingdom,United Kingdom,Poland,United Kingdom,Netherlands,Portugal,Italy
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2015-03-31
Duration (months): 39.0
Total project cost (EUR): 4037464.0
EU funding (EUR): 2932684.0
Participants: 14
Project status: CLOSED

This proposal aims to improve safety and quality of RTE fresh produce throughout the whole chain by developing new predictive and probabilistic models and decision-making tools, by exploring rapid and non-destructive methods for quality evaluation and prediction, and by experimenting novel technologies, in order to quantify and manage spoilage and pathogen microorganisms, minimize risks to consumers, and preserve quality. Objectives of the proposal will be reached through the realization of 9 WPs. WP1 will develop diagnostic kits to predict quality and safety of raw material and final product. WP2 will develop process control aids based on non-destructive and rapid evaluation. WP3 will develop decision support tools in very critical points of processing chain. WP4 will investigate innovative processes to improve quality and safety of fresh-cut products. Technological innovations will go through implementation and demonstration in WP5 and through an economic evaluation approach in WP6. Results will represent valuable information in order to re-visit and improve good practice procedures or, to define a more efficient management system for quality and safety (in WP7). Finally results will be disseminated to potential users in WP8, while WP9 will consist of the management of the consortium. The participants are 14, of 7 Countries including 6 SMEs, 2 public research Institutes and 6 Universities, assorted in terms of scientific and technological expertise. The presence of SME will ensure the exploitation of the results directly and indirectly. Potential impacts of the results of this project may be related to the increase of scientific evidences about safety and quality, expansion of consumer awareness, increase of the innovation capacity of the industry strengthening its competitiveness, provision of scientific evidences to the EC and other health authorities (also for campaigns for healthy nutrition), and a reference point to mass media.

Keywords: fresh-cut,safety,quality,pathogen,risk,degradation,predictive modelling,decision-making tool,diagnostic kits,intelligent packaging,non-destructive,nutrition
Promoting a functional and comparative understanding of the conifer genome- implementing applied aspects for more productive and adapted forests. (PROCOGEN)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Spain,Spain,France,Sweden,Belgium,Austria,Finland,Italy,Portugal,United Kingdom,Netherlands,Spain,United Kingdom,Canada,Sweden,Spain,Norway
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 7754578.7
EU funding (EUR): 5978303.0
Participants: 23
Project status: CLOSED

In the midst of a climatic change scenario, the genetics of adaptive response in conifers becomes essential to ensure a sustainable management of genetic resources and an effective breeding. Conifers are the target of major tree breeding efforts worldwide. Advances in molecular technologies, such as next-generation DNA sequencing technologies, could have an enormous impact on the rate of progress and achievements made by tree breeding programmes. These new technologies might be used not only to improve our understanding of fundamental conifer biology, but also to address practical problems for the forest industry as well as problems related to the adaptation and management of conifer forests. In this context, ProCoGen will address genome sequencing of two keystone European conifer species. Genome re-sequencing approaches will be used to obtain two reference pine genomes. Comparative genomics and genetic diversity will be closely integrated and linked to targeted functional genomics investigations to identify genes and gene networks that efficiently help to develop or enhance applications related to forest productivity, forest stewardship in response to environmental change or conservation efforts. The development of high-throughput genotyping tools will produce an array of pre-breeding tools to be implemented in forest tree breeding programmes. ProCoGen will also develop comparative studies based on orthologous sequences, genes and markers, which will allow guiding re-sequencing initiatives and exploiting the research accumulated on each of the species under consideration to accelerate the use of genomic tools in diverse species. ProCoGen will integrate fragmented activities developed by European research groups involved in several ongoing international conifer genome initiatives and contribute to strengthening international collaboration with North American initiatives (US and Canada).

Keywords: genomics,adaptation,conifers,forest species,breeding,high-throughput sequencing and genotyping.
Reproductive Biology Early Research Training (REPRO-TRAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Netherlands,France,Germany,United Kingdom,Italy,United Kingdom
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 3649828.0
EU funding (EUR): 3649828.0
Participants: 8
Project status: CLOSED

The “Reproductive Biology Early Research Training” network (REPRO-TRAIN) aims to provide all the elements required to train the next generation of researchers with the latest skills to solve the current societal problems in male reproductive biology (Andrology). The decline in sperm counts and concomitant increase in testicular cancer demands research in this field as an urgent priority. Spermatogenesis is the essential physiological process for male gamete production. It also provides a ideal paradigm model system to study cellular development and differentiation; necessary for an understanding of dysfunction. An innovative aspect of this ITN is to harness Systems biology into Reproductive Science. Here, we offer a high calibre, multidisciplinary research environment involving frontier “omic” approaches in male reproductive biology for the first time with the aim of identifying the gene networks that are deregulated in the infertile testis. The REPRO-TRAIN programme will integrate this highly interdisciplinary training with knowledge transfer to strategic stakeholders. We will include universities and research institutes with internationally recognized experience in postgraduate training, hospitals recognized for high quality clinical training and key private companies. This trans-national, inter-disciplinary research network will provide a robust platform for the success of the proposed ITN. Ten ESR and four ER researchers will perform studies in genetics and epigenetics, molecular male reproductive medicine, molecular and structural biology, and biotechnology with hands-on training in cutting-edge technologies relevant to current molecular-genetic and medical research. A clear definition of their Personnel Career Development Plans, training in complementary skills allied to business and the coordination between the elements that compose this plan are detailed herein.

Keywords: health science,reproductive biology,andrology,spermatogenesis,germinal cell line,genomics,epigenomics,transcriptomics,proteomics,model systems,systems biology,training,transfer of knowledg
EUropean TRanslational training for Autoimmunity & Immune manipulation Network (EUTRAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,Italy,Germany,Italy,United Kingdom,France,Germany,Germany
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 3762774.41
EU funding (EUR): 3762774.41
Participants: 11
Project status: CLOSED

Immune-mediated inflammatory diseases (IMID) are important health challenges in Europe and beyond, afflicting an estimated 5-8% of the total population. IMID with an onset during childhood such as Juvenile Idiopathic Arthritis (JIA) cause particular concern as pediatric patients form an especially vulnerable group. Currently there is no safe and cost-effective cure for JIA and related juvenile IMID. Thus, these children face lifelong treatment with serious consequences both for the patient (high risks of long-term side effects) and for society as a whole (high costs). Translating the progress in molecular medicine into new therapies for JIA has also met with limited success. The route from idea to drug has many hurdles and is a very fragmented process. Translational medicine encompasses the continuum of activities that extend from the conception of an idea to advanced clinical testing and, ultimately, to the development of a new medical technology or drug. This itinerary includes many components that require very different skills such as biomedical research skills, design of pre-clinical and clinical trials, regulatory issues, legal issues, intellectual property rights, communicational skills and more. Such skills are often compartmentalized within three separate domains—academia, government and industry. Each of these domains has its own set of challenges. If we are to really change the way in which we are thinking and working in the drug development process it will be essential that we start with changing the education process of our students. EUTRAIN brings together leading scientists and institutes in the field of IMID. Its goal is to provide the next generation of researchers with insights, tools and knowledge necessary to bridge the gap between bench and bedside in IMID. In doing this EUTRAIN addresses two specific needs: the need for novel therapeutic approaches for IMID and the need for novel approaches in translational medicine.

Keywords: immunology,pediatrics,chronic diseases,immune-mediated inflammatory diseases,juvenile idiopathic arthritis,translational medicine,research training network