Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Neuroscience and Narratives of Intimacy (NNI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-15
End date: 2018-05-14
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

As human beings, we tend to connect. Yet social isolation is a widespread condition with grave consequences on life-expectancy. Ideals of self-sufficiency and new modes of communication incite to isolate rather than attach. By contrast, experiencing meaningful intimate interactions has positive effects on health. But what is intimacy, where is it to be found, has it changed and how can it be studied? Infused with a robust public engagement component, the intended programme of research involves collecting narratives of intimacy from the general public to derive elements of its every day lived experience. Be these obstacles to (shame, fear, attachment deficits) or catalysts for (authenticity, vulnerability, trust) intimacy, the project then scrutinises past and current neuroscience and psychology research that can explain them. The project also aims at finding out whether brain explanations of intimacy resonate loudly with people and in popular culture and whether they disenchant the value of social connection. Overall, the proposed approach bears a twofold potential: On one hand, the intimacy narratives identified may translate into instructive inspiration for the design of experiments by the scientific community. On the other hand, the public will be exposed to and question scientific accounts of intimacy, as well as report whether or not a scientific interpretation of intimacy reconciles with experience. Ultimately, it will be possible to probe levels of incommensurability as well as possible convergences between scientific empiricism and lived experience, data and phenomenology, measurements and narratives and, thereby, test an effective dialogue between the medical sciences and the humanities, as well as science and society. If awarded, this fellowship as well as the training and original work arising from it will allow the fellow to push innovative research boundaries and achieve the appropriate intellectual maturation for a long-term independent career.

Keywords: neuroscience,intimacy,medical humanities,narratives,science and society,citizen science,social neuroscience,public engagement
Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses (SATBIOFUN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 233555.4
EU funding (EUR): 233555.4
Participants: 2
Project status: CLOSED

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the overarching objective of developing the Fellow’s career to a position of professional maturity, thereby facilitating her long-term goal of establishing her own independent research group in Europe.

Keywords: centrosome,centriole,primary cilium,gene targeting,reverse genetics,ciliopathy,tissue culture
Directed crop breeding using jumping genes (BUNGEE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland,France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 1965624.99
EU funding (EUR): 1604521.74
Participants: 2
Project status: CLOSED

The rapidly changing climate puts commonly used crop plants under strong pressure. It is therefore essential to develop novel breeding technologies to rapidly enhance crops to better withstand newly emerging stresses. Interestingly, a clear link between transposable elements (TEs), crop improvement and varietal diversification exists. Furthermore, in recent years the importance of (TEs) in evolution and adaptation to stresses has been recognized. However the use of TEs in crop breeding is currently very limited because it is not possible to control TE mobility. My research group has identified a novel highly conserved epigenetic silencing mechanism that represses the activity of TEs in Arabidopsis. We also found drugs capable of inhibiting this mechanism. Because these drugs target highly conserved enzymes we were able to show that our drug treatment is also effective in rice. We are therefore able to produce TE bursts in a controlled manner in virtually any plant. We can thus, for the first time, generate and study TE bursts in crop plants in real time. More importantly, we found that the accumulation of novel insertions of a heat-stress inducible TE produced plants that, at a high frequency, were more resistant to heat stress. This suggests that the stress that was initially applied to activate a specific TE in the parent, lead to an improved tolerance to that specific stress in the progeny of that plant in a very straight-forward manner. In this project I propose to accelerate plant breeding by testing and implementing a revolutionary TE-directed crop improvement technology. For that I plan to 1. Mobilize TEs in crop plants using selected stresses 2. Using these mobilized stress-responsive TEs breed novel crop plants resistant to those selected stresses and 3. Study the genetic and epigenetic impact of TE mobilization on host genomes. This project will have a broad impact on crop improvement and on the basic understanding of the evolutionary importance of TEs.

Keywords: new crop breeding technologies,transposable elements,stress tolerance,epigenetics,rice,soybean
Beamline for Tomography at SESAME (BEATS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Italy,Cyprus,Poland,Switzerland,Jordan,France
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6447937.5
EU funding (EUR): 5967937.5
Participants: 9
Project status: SIGNED

The overall objective of the project Beamline for Tomography at SESAME (BEATS) is to pave the way for an efficient and sustainable operation of the Synchrotron light for Experimental Science and Applications in the Middle East (SESAME) research infrastructure. The project builds upon the OPEN SESAME project, and has the following key objectives: • Develop and consolidate the scientific case and build up a science community, paying particular attention to the R&D and technology needs of the SESAME Members and beyond. Today, there is already significant interest from the Cultural Heritage and Archaeology community. Applications in Environmental and Materials Sciences, with links to industries in the region, shall also be explored; • Design, procure, construct, and commission a beam line for hard X-ray full-field tomography at SESAME; • Foster collaborations among the project partners in all aspects of the technical work to ensure that a comprehensive transfer of knowledge to SESAME staff is accomplished within the lifetime of the project; • Address the issue of sustainability of operation by preparing medium- to long-term funding scenarios for the tomography beamline. The consortium is a blend of leading research facilities in the Middle East (SESAME and the Cyprus Institute), well established European synchrotron radiation facilities and high-energy laboratories (DESY, ELETTRA, ESRF, INFN and PSI) with a decades-long experience in synchrotron radiation research and technology, and more recently founded synchrotron laboratories (ALBA and SOLARIS).

Keywords: synchrotron radiation,sesame tomography beam line,cultural heritage,environmental science,user community,capacity build up,sustainability
Eukaryotic DNA replication: a single-molecule approach to the study of yeast replication on chromatin (REPLICHROMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 2388100.0
EU funding (EUR): 2388100.0
Participants: 1
Project status: SIGNED

DNA replication is essential to cellular function. During a lifetime, each of us synthesizes a light-year’s length of DNA, but this process is so robust that few of us will develop cancer. In eukaryotes, DNA is packed into chromatin, a hierarchical DNA-protein assembly of which the nucleosome forms the basic unit. Chromatin replication convolves DNA replication with the duplication and reassembly of all DNA-associated proteins. Understanding the coupling between these processes has fundamental implications for epigenetic inheritance and cancer. The goal of this proposal is to gain spatiotemporal insight into chromatin replication by using our biophysical expertise in replication and chromosomal dynamics to build up a mechanistic timeline of the process. We will harness recent advances in the reconstitution of the yeast replisome alongside our novel, high-throughput single-molecule approach to visualize and quantify the collaboration between a single yeast replisome and the histone chaperones to achieve chromatin replication. We will: •Monitor the assembly of the replisome on chromatin and visualize how nucleosomes impact its progression. •Quantify how the replisome and histone chaperones disrupt nucleosomes and retain histones for further processing. •Detect the deposition of newly synthesized histones behind the replisome and reveal the interactions between replisome components and histone chaperones that couple replication to nucleosome assembly. •Report on the phenomenon of epigenetic inheritance by imaging histone recycling between parental and daughter DNA. We will examine its timing and efficiency, the conformations of reassembled nucleosomes, and any preferential recycling to either daughter DNA. This proposal places us in a unique position to make major contributions to the field of chromatin replication, and to provide the field with a powerful tool to investigate topics from fundamental questions in molecular biology to the performance of new cancer drugs.

Keywords: dna replication,eukaryotic replication,yeast replication,chromatin,nucleosomes,histone chaperones,nucleosome assembly,single molecule biophysics,fluorescence microscopy,magnetic tweezers
Building the world's largest Application Programming Interface (API) for law, Vizlegal will change how legal information is utilised and understood by the legal industry. (VIZLEGAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Vizlegal is a legal intelligence platform that empowers legal professionals to track, search and save critical legal information from EU institutions and the courts of a growing number of member states. Traditional systems are focussed on making large amounts of text searchable; Vizlegal proposes to scale our system for converting valuable public information into data, thus opening opportunities for new artificial intelligence and analytics products. Our research says that lawyers are confronted with a number of serious issues when it comes to their work. These include; having to search court filings systems repeatedly to see if something has changed or happened; learning a key judgment relevant to them has been issued, months after the fact; inability to tell what rules of court apply in certain circumstances; inability to search or track key decisions of quasi-judicial public bodies in multiple member states. Vizlegal aims to solve these issues by converting public government information into data, and offering new tools to address these issues. We have built a sophisticated Extract/Transform/Load (ETL) system to grab pubic information, structure it, parse it, and put it into a growing legal Application Programming Interface (API). This API serves a web application currently serving a growing list of customers. It is also serving a data marketplace provider for UK-based finance companies. We aim to expand our data extraction via ETL, and gain more customers via a) a focus on niche data ignored by other providers and b) a ratio of accessible information to price unseen before in the industry. We will be liberating closed data into open data, and serving a key industry in any member state, and internationally. We believe that the data we gather can offer enormously valuable future products in the analytics and intelligence sphere.

Keywords: legal,legal data,open data,legal intelligence,artificial intelligence,open law,public data,government information,government data,courts intelligence
Laser EnAbled TransFer of 2D Materials (LEAF-2D)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Israel,Spain,Greece,Greece,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 2851030.0
EU funding (EUR): 2851030.0
Participants: 7
Project status: CLOSED

2D Layered Materials (2D LM) hold enormous promise for enabling new device concepts and novel applications, owing to their planar nature and their exquisite, tuneable properties. Despite the rapid advancement of many aspects of Layered Materials (LM) technology, many emerging applications are hampered by the lack of an efficient, defect-free and controllable technique for the transfer of pixels of LM onto desired substrates. The core concept of this proposal is the development of a novel nano-manufacturing technology based on laser transfer techniques, which will enable the rapid, intact transfer and engineering of 2D stacks and heterostructures for optoelectronic, photonic and organic electronic devices. To achieve this, we will benefit from the unique advantages of the Laser Induced Backward Transfer (LIBT) and Laser Induced Forward Transfer (LIFT) techniques, which among other attributes, offer the capability for intact transfer of any 2D LM with high lateral resolution (micron scale), the transfer of 2D heterostructures and compatibility with a variety of substrates, including Si and flexible substrates. The implementation of the proposed technology will offer a chemical- and defect -free transfer of 2D monolayers with high precision: exquisitely clean Si-2D semiconductor (SC) heterostructures will be demonstrated using LDT and enable the fabrication of Near-IR Si emitters. Single layer and defect – free Graphene pixels will be printed on flexible substrates for highly sensitive ultra-thin sensors. These breakthroughs in the fields of Si emitters and flexible touch sensors will validate the importance of LEAF-2D and facilitate the incorporation of 2D materials in a plethora of emerging technological fields.

Keywords: laser direct transfer,2d layered materials,nanomaterials engineering,si emitters,flexible sensors
Improving the stability of high-quality traits of berry in different environments and cultivation systems for the benefit of European farmers and consumers (GoodBerry)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Germany,Spain,Italy,Spain,Germany,Spain,Spain,Norway,Poland,China,Belgium,France,France,Chile,United Kingdom
Call: Strategies for crop productivity, stability and quality (H2020-SFS-2015-2, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 4868332.5
EU funding (EUR): 4868332.5
Participants: 21
Project status: CLOSED

The main objective of GoodBerry is to provide the necessary knowledge and procedures to facilitate the development of highly productive and top quality berry fruits, even under multiple suboptimal growth conditions, at a competitive cost. The project is based on an integrative multi-actor approach, from cultivation techniques to molecular studies, aiming the development and validation of a range of tools to improve competitiveness of European berry production, and eventually the attraction and confidence of consumers. The selection of the model species can be considered as strategic since strawberry is the most important berry crop in Europe and the production of raspberry and blackcurrant are increasing strongly in recent years. The project will apply the most recent technical advances in: a) The identification of berry germplasm exhibiting advantageous balance of production vs nutritional quality throughout the EU, b) The search of innovative production systems to maintain high yield in a range of European-wide environments, c) The development of standardized and reliable analytical tools to evaluate berry production and fruit quality. As result, it is expected: a) the implementation of modern breeding strategies to accelerate the release of new berry cultivars; b) The adoption by EU-growers of high quality production systems to improve fruit quality. The proposal establishes as obligatory to disseminate and communicate the results to the scientific community, industry, the broad public and interested stakeholders user. The final impact will be to consolidate the emerging needs of high-quality berries, and to boost consumer and market confidence supported by an improved competitiveness of producers. It is a multidisciplinary, collaborative project based on complementary expertise and skills of internationally recognized berry research institutions, and highly involved key berry SMEs that will combine their effort to secure the robustness of the results.

Keywords: berry germplasm,flower initiation,dormancy,production,fruit quality,cultivation techniques,omic approaches,climate changes,systems biology,consumer confidence,sustainable production
Validation of a conceptually new treatment for glioblastoma multiforme with an IP protected small molecule (GlioVac)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-03-01
End date: 2016-08-31
Duration (months): 18.0
Total project cost (EUR): 149693.0
EU funding (EUR): 149693.0
Participants: 1
Project status: CLOSED

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with marginal life expectancy even with the most aggressive available therapy. We have identified a previously unanticipated vulnerability of GSCs which when targeted, leads to a rapid and complete cell death of all tumor cells isolated from nine different patients diagnosed with GBM. The cellular mechanism has been identified and involves an increased vulnerability of GSCs to massive vacuolization which can be induced by a small molecule, termed Vacquinol-1. The vacuolization results from an induction of massive macropinocytosis leading to cytoplasmic membrane rupture and cell death. Vacquinol-1 reduces viability in vitro with approximately 70 times greater potency than current chemotherapy and efficiently and significantly reverses disease and prolongs survival in animal models of human GBM. Vacquinol-1 is highly selective for glioblastoma cells and is not present in other examined cell types, including astrocytes from the brain. Vacquinol-1 has favorable pharmacokinetics, oral bioavailability and exhibits excellent overall preclinical characteristics. Synthetic chemical expansion of Vacquinol-1 reveals an exquisitely delicate structure activity relationship. IP protection has been filed. In order to be able to validate this discovery into an innovation and possible commercialization we need to: 1) Compare potency and efficacy with competing compounds in development stage. 2) Establish optimized dosage regimen from in vitro and in vivo cytotoxicity and brain exposure measurements. 3) Develop a GMP-compatible stereo-selective synthesis of an appropriate Vacquinol-1 isomer for amending composition of matter to patent and pre-GLP/GLP toxicological and phase I clinical trials. 4) Together with Karolinska Institutet Innovations AB protect the intellectual property, validate commercialization potential and establish a development plan.

Keywords: glioma,glioblastoma,macropinocytosis,vacuolization,cancer,small molecule