Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact (A CACTUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 149875.0
EU funding (EUR): 149875.0
Participants: 1
Project status: CLOSED

The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody labelling. Recent evidence showed that non-epithelial cancer cells, which are not detected by CellSearch, are of critical importance in cancer progression. The idea: Our CTC detection method is based, instead of on antibody labelling, on metabolic features of cancer cells, thus providing potential for detecting both epithelial and mesenchymal cancer cells. Cancer cells induce environmental changes; e.g. in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect. By separating cells into micro-droplets of pico-liter volume using micro-fluidic water-in-oil emulsions and by characterising the microenvironment surrounding them, CTCs are detected by probing for environmental changes using pH sensitive dyes or enzymatic lactate assays. Our inexpensive diagnostic method provides a way to count and isolate CTCs without any labelling while maintaining cells alive and intact for further studies. The project: “A CACTUS” is meant to assess the feasibility of commercialising the developed method for counting and sorting CTCs and develop a proper commercialisation strategy. The final goal of this project is to develop a proposition package consisting of technical proof of concept, the business proposition and strategy and an IP portfolio and strategy. This information will be presented in an attractive business plan that will be proposed to potential investors.

Keywords: metastasis,circulating tumour cells,cancer,tumour,metabolic,single cell analysis,picodroplet,diagnosis,prognosis,in vitro devices,epithelial,high throughput,label free,enumeration
Researchers, moving Europe forward. Meet them, join them! (MadridERN2016-2017)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-12-31
Duration (months): 20.0
Total project cost (EUR): 223975.5
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

Under the motto ‘Researchers, moving Europe forward. Meet them, join them!‘, European Researchers’ Night in Madrid, 2016-2017 underlines the importance of researchers’ work for the advancement in Europe, offering public at large, students, children and families the opportunity to meet them, talk to them, know the work they carry out and how they spend their free time. Showing their hobbies, their hopes and their enthusiasm for the work they accomplish. A strong and timely awareness campaign will be launched combining traditional communication vectors with on line ones ( social networks, website, blogs…) 72 appealing activities will be held in a playful and relaxing atmosphere in different venues of seven cities in the Region of Madrid covering varied neighbourhood where people with diverse interests and backgrounds live. Special attention will be paid to young people in order to encourage them to embark on scientific careers and also to foster the entrepreneurial and innovative spirit among them. All scientific disciplines will be represented along with other issues such as arts, sports, literature, cooking, etc. Gender balanced will be also taken into account as well as the Responsible Research and Innovation (RRI) in order to foster the design of inclusive and sustainable research and innovation. The involvement of the societal actors and stakeholders is a guarantee of public engagement. Researchers benefited by European programmes and Marie Skłodowska-Curie fellows will join the activities, having a real presence in the Europeans’ corners, highlighting therefore the European dimension of the event. Common actions will be performed together with another European Researchers’ Night in Europe and in Spain and also if appropriate in the same Region.

Keywords: european researchers night,researcher,society,public recognition,public engagement,research job,schools,citizens,entrepreuners,students
Biodiversity Erosion in European medicinal Plants (BEEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Environmental degradation due to land-use, over-exploitation and climate change rapidly erodes Europe’s unique biodiversity, resulting in irreversible loss of valuable resources both for ecosystem functions and for human well-being. However, despite the numerous monitoring and conservation efforts, our ability to predict and mitigate the extinction risk of wild populations remains limited. Assessing the temporal variation in genetic diversity and its environmental drivers represents a powerful approach to address this challenge, but incorporating it into conservation planning has been hindered by i) lack of affordable technology, ii) lack of interdisciplinarity, and iii) disconnection between fundamental research and applied conservation. BEEP will address these gaps by combining modern sequencing technologies for quantifying species temporal genomic erosion, with satellite observations of the earth for assessing the corresponding environmental change. By bridging diverse technological fields and scientific principles, BEEP will provide an applied predictive framework for species extinction risk in response to human pressure that can be directly utilised by major environmental organisations (IUCN, EEA, IPBES). I will showcase the power and importance of this approach using the European endemic and highly threatened mountain tea species (Ironwort), that are of significant conservation interest due to their traditional and emerging medicinal properties. I will achieve BEEP's objectives at SBiK-F (Senckenberg Biodiversity and Climate Research Centre), a world-class centre in interdisciplinary biodiversity research, ranging from earth observations from space to species evolutionary genomics.The proposed project will provide new research and training opportunities that will bring me in a very competitive position in order to successfully establish myself as a leading and interdisciplinary European researcher in the fields of biodiversity research and conservation.
Origin and evolution of land plant reproductive system (EVREP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Israel
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 258205.44
EU funding (EUR): 258205.44
Participants: 2
Project status: SIGNED

Land plants constitute a significant part of the world’s biomass and the human diet. The transition of plants to a land-based habitat led to profound developmental innovations. A major change was the formation of a sexual-based reproductive system. In basal land-plant linages, the haploid-gametophytic phase dominates the life cycle. In later linages the diploid-sporophytic phase took a more prominent role. This switch involved the elaboration of an embryo-based reproductive system. However, there is a significant gap in our understanding of the evolutionary, genetic and developmental mechanisms that enabled the formation of a sexual reproductive system. We hypothesize that embryo evolution entailed two key consecutive events: 1. Cell proliferation and growth following fertilization and prior to meiosis, which generates the sporophyte. 2. Specification of a subset of cells as sporogenous cells, which will generate the spores. Based on published work and recent data from the host lab, we propose that the first step involves class I KNOTTED1-like homeobox (KNOX1), and the second, class III Homeodomain-Leucine Zipper (C3HDZ). In the proposed research, we aim to use the basal land plants to 1. characterize the role of KNOX1 genes in sporophyte formation and 2. Identify regulators of sporogenous formation by identifying C3HDZ targets and determine their role in sporogenous specification. The proposed research is expected to elucidate the molecular network underlying reproductive development of land plants and its evolution. This may unravel basic principles of developmental innovations that enable the evolution of land plants and the conquest of novel habitat. This postdoctoral fellowship will provide me with an opportunity to be trained in the field of evolutionary-developmental biology and to achieve my future goals as an independent scientist.

Keywords: land plant evolution,class iii hd zip,marchantia,reproduction,knox
Securing Software against Physical Attacks (SOPHIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2021-12-31
Duration (months): 64.0
Total project cost (EUR): 1964750.0
EU funding (EUR): 1964750.0
Participants: 1
Project status: CLOSED

More than 15 years ago, several seminal publications showed that cryptographic keys can be revealed by analysing the power consumption or by inducing faults to devices like smart cards. The publication of these so-called physical attacks sparked off research on all kinds of attack techniques and countermeasures to secure implementations of cryptographic schemes. However, a system can still be attacked easily if only the execution of cryptographic schemes is secured. An attacker can for example induce a fault to bypass an authentication or to jump to a privileged function directly. The system might also leak the key before the execution of a cryptographic scheme starts. Today, there is almost no research on securing systems and software execution against physical attacks. Products like smart cards rely on proprietary best-practice countermeasures. Also countless devices of the Internet of Things are exposed to physical attacks and lack protection. Our goal is to close this fundamental gap in system security and to establish the scientific foundation for executing software securely and efficiently in the presence of physical attacks. We aim to address research questions that range from the modelling of the attacks at the hardware level up to system-level questions like how changing properties of programming languages can support achieving protection against physical attacks. This project brings together research on physical attacks, cryptography, system architectures, fault tolerant design as well as formal methods. Combining the fields, we pursue novel approaches to securing the control flow, CPU computations and memories. We in particular aim to find efficient methods in hardware and software that allow building systems where critical parts of the overall software can be secured against physical attacks without affecting or trusting the rest of the system. Our research also includes automated generation and verification techniques for the secured software.
Impact of whole-genome duplications on the genetic and genomic architecture of adaptation (POLYGARCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Whole-genome duplication (WGD) is arguably the most severe mutation that an organism may undergo. As such, WGDs are often fatal, but the resulting polyploids that survive the initial shock to cellular processes may ultimately thrive. Whether conditions created by WGDs are beneficial or detrimental to adaptation is a long-standing question in evolutionary biology, with important implications for domestication and crop breeding. A key determinant of evolutionary responses is the genetic and genomic architecture of adaptive traits: i.e. the control of phenotypes by one or many loci, the interactions between alleles, positions of loci in relation to genomic features, and structural arrangements. By combining cutting-edge evolutionary modelling, novel machine-learning tools, and multi-species genomic data from short- and long-read sequencing, I propose to determine how WGDs alter the genetic and genomic architecture of local adaptation. Such knowledge will advance our understanding of the evolutionary success of polyploids, provide insights into factors influencing the current distribution of polypoid populations and species, as well as yield important information for predicting how polyploids respond to environmental change.

Keywords: polyploidy,local adaptation,genetic architecture,structural variation
Action “Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network” (INNOVSUPPWALES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom,United Kingdom
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 16560.0
EU funding (EUR): 13248.0
Participants: 2
Project status: CLOSED

In order to address the challenges of increasing SMEs innovation potential and enabling them to bring their innovative ideas to the market, new programmes and support systems have been designed. Europe recognises the importance of innovation and SME’s as growth drivers and as such, this action shall provide specialized consulting services addressing the innovation management capacity of SMEs which possess significant innovation activities. Beneficiaries of the SME instrument shall as well receive support to enhance their innovation management capacity through this action. The Enterprise Europe Network is embedded in the regional innovation ecosystem within Wales, and will provide support for raising the innovation capacity of Welsh SMEs. This will be completed under the two types of 7 day packages of support available, which are: 1) Enhancing SME Innovation Management Capacity 2) Key Account Management for the beneficiaries of the SME Instrument. The objective of these services will be increasing and accelerating the economic returns from innovation in SMEs. A number of deliverable outputs have been defined in section 2.1 in order to ensure that the project meets the overall objective. The aim will be to strengthen the innovation capacity of SME’s and their contribution to the development and commercialisation of new technology. By expanding relevant networks, increasing the research effort and better exploitation of IP, Wales can maximise the ROI. The overall objective is to: • increase the economic impact from European R&D and innovation investment • improve the innovation capability of SMEs in Wales

Keywords: enhancing innovation management capacity
A new class of microtubules in the spindle exerting forces on kinetochores (NewSpindleForce)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Croatia
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 2150000.0
EU funding (EUR): 2150000.0
Participants: 1
Project status: CLOSED

At the onset of division the cell forms a spindle, a micro-machine made of microtubules, which divide the chromosomes by pulling on kinetochores, protein complexes on the chromosome. The central question in the field is how accurate chromosome segregation results from the interactions between kinetochores, microtubules and the associated proteins. According to the current paradigm, the forces on kinetochores are produced by k-fibers, bundles of microtubules extending between the spindle pole and the kinetochore. The proposed project is built upon a groundbreaking hypothesis that a new class of microtubules, which we term bridging microtubules, bridge sister kinetochores. Our preliminary results show that bridging microtubules are responsible for the positioning of kinetochores in HeLa and PtK1 cells. Bridging microtubules have not been studied before because this requires cutting-edge microscopy and laser microsurgery techniques. By applying these methods, with which I have extensive expertise, we will determine the organization of these microtubules, identify the proteins that link them with k-fibers, and uncover where and how the forces for kinetochore positioning and movement are generated. My strength is in taking an interdisciplinary approach, which I will use in this project by combining laser microsurgery with genetic perturbations, quantitative measurements of the responses and comparison with theoretical models. Understanding the role of bridging microtubules in force generation and chromosome movements will not only shed light on the mechanism of chromosome segregation, but may also increase the potential of mitotic anticancer strategies, as the spindle is a major target for chemotherapy. The proposed ERC funding is essential for the success of these timely and ambitious experiments, allowing me to strengthen my position as an international leader in research on cell division, thereby increasing Europe's foremost position in this field.

Keywords: mitotic spindle,microtubules,kinetochores,motor proteins,forces,live cell imaging,laser microsurgery,modeling
Composite joints for improved mechanical and electrical performance (C-JOINTS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom
Call: Developing innovative joining concepts and their manufacturing methodologies (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-04-01
End date: 2019-09-30
Duration (months): 30.0
Total project cost (EUR): 498780.0
EU funding (EUR): 498780.0
Participants: 2
Project status: CLOSED

CC-JOINTS will explore new innovative joint designs that can be broadly described in two ways: • Modification of the metal in order to facilitate improved joint strength • Introduction of through-thickness reinforcements that can improve the composite performance and provide means for joining to the metal • A new method for riveting composite-metal joints using laser Effective protection from lightning strike (LSP ) will be provided by application of a metallised coating through thermal spray at the surface of the joints and use of the through-thickness reinforcement as electrical current carriers away from the joint. The main objectives of the project are: • Optimise existing joints designs for a number of joint geometries as defined in call Topic • Apply innovative and established joining technologies to selected joint geometries • Test the new joint solutions and integrate them to the demonstrator part • Techno-economic analysis of the new joints The new joints are classified in four categories, based on their function, whether they are permanent or not and on the type of composite (laminate of honeycomb) that is joint to the metal. This classification can be considered as a first step towards a wider classification of hybrid joints in aircraft that will enable a more holistic approach in their design and integration to the overall structures.

Keywords: hybrid joints,through thickness reinforcement,adhesive bonding,lightning strike protection,thermal spraying,coatings on composites