Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DEVELOPMENT OF NOVEL ASSESSMENTS FOR INDOOR AIR QUALITY MONITORING AND IMPACT ON CHILDREN'S HEALTH (LEARN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Portugal,Belgium,Greece,Germany,Netherlands,Switzerland,Denmark,Spain
Call: Indoor air quality and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-05-01
End date: 2026-04-30
Duration (months): 48.0
Total project cost (EUR): 7550976.25
EU funding (EUR): 7550974.0
Participants: 12
Project status: SIGNED

LEARNing about the status of air quality in schools and its impact on the cognition of children is a major cornerstone in LEARN. For that, we want to overcome the barriers of the currently existing technologies and take a bold step towards the development and deployment of novel sensors to detect the presence of possibly harmful air pollutants such as volatile organic compounds and ultrafine particles. We will measure and characterize indoor and outdoor air pollutants and evaluate the presence of biomarkers of exposure and their effect on children´s cognition, while trying to recapitulate those effects using C.elegans as biosensor. Moreover, we will use advanced human-based in vitro models of lung and skin coupled to a revolutionary multisensing device to investigate their mechanisms of toxicity in real-time. Novel remediation strategies will be explored to improve air quality and promote children´s quality of life and life expectancy. For that we will mobilize a group of eleven leading research teams, unrivalled in their respective fields (environmental epidemiologists, toxicologists, air quality specialists, systems biology, engineers and citizen/social scientists). The scientific achievements expected to result from LEARN will unlock a large technology potential in IAQ for decades to come, leading to disruptive societal and economic impacts steaming from a radical improvement in the quality of life of children in Europe. Project LEARN is part of the European cluster on indoor air quality and health.

Keywords: school cohorts,sensor,biomarkers of exposure,ultrafine particles,volatile organic compounds,organ on a chip,biosensor,air filtration,public engagement
Multilingual and Multicultural Spaces for Political Deliberation (MultiPoD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Portugal,Greece,United Kingdom,France,Belgium,Spain
Call: Political participation in multilingual spaces (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 2998251.25
EU funding (EUR): 2998251.25
Participants: 9
Project status: SIGNED

As highlighted by the Conference on the Future of Europe, EU citizens at large feel that the interplay between national media discourse and political/cultural contexts affects the perceptions and reactions to global events differently. Language barriers exacerbate siloed thinking, the bandwagon effect, group thinking, and the lack of diversity in dialogue around issues of international relevance, creating “areas” of thinking entrenched into national and language gates and hindering the creation of a truly European public sphere. Such challenges to democratic participation disproportionally affect members of cultural and linguistic minorities within and across EU member states. The research and innovation roadmap of the MultiPoD project aims to radically improve the political dialogue at the European level through evolving knowledge graphs and generative, Artificial Intelligence-driven technologies that mobilise collective intelligence, bridge existing communication barriers, and yield a better understanding of the interdependencies between participatory processes, policy decisions and behavioural, thought and argumentation patterns in the public deliberation of international affairs. For this purpose, MultiPoD brings together experienced use case partners, as well as European networks engaged in fostering participatory, deliberative democratic processes, technology partners with a strong track record in multilingual language processing, and leading research partners, specialised in collective intelligence, argumentation theory, human-computer interaction and visual methods for supporting and analysing online communication.

Keywords: hybrid citizen deliberation,deliberative democracy,multilingual political dialogue,cross cultural argumentation,automated knowledge extraction,visual analytics
Quantitative Ultrasound Stochastic Tomography - Revolutionizing breast cancer diagnosis and screening with supercomputing-based radiation-free imaging. (QUSTom)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,United Kingdom,Slovenia
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2024-09-30
Duration (months): 30.0
Total project cost (EUR): 2744300.0
EU funding (EUR): 2744300.0
Participants: 6
Project status: CLOSED

Ultrasound imaging can be deeply enhanced by means of algorithms developed in the field of geophysical imaging. Such algorithms, based upon adjoint-state modelling and iterative optimization, provide quantitative images of human tissue with very high resolution. At present time, such images can only be attained by means of high-performance computing and using specific ultrasound data acquisition devices. When combined, hardware and software have a huge impact potential for soft-tissue imaging, such as in breast cancer imaging. Nevertheless, and as is customary in medical imaging, the obtained images only provide with the mean, or most likely, values of tissue at each pixel, being uncertainty quantification an extremely expensive process, typically deemed as unfeasible for practical purposes. A revolutionary development in adjoint-based ultrasound imaging allows us to potentially obtain images of uncertainties at the cost of a single, mean-value, image. Such development will be the basis of transformative implications in terms of confidence-estimates for diagnosis. We aim at disrupting the breast cancer screening paradigm by means of a safe (radiation-free), accurate (quantitative) and reliable (uncertainty-aware) novel breast imaging modality. Within QUSTom we will investigate the fundamental science behind adjoint-based uncertainty imaging and establish its potential suitability for breast cancer diagnosis. The feasibility of the technology as a diagnosis tool relies on 1) adapting the data acquisition hardware for optimal resolution, 2) implementing the algorithms in high-performance computers in order to obtain a short time-to-solution and 3) feasibility analysis by expert radiologists in comparison with the state-of-the-art in breast imaging. This proposal covers the three aspects and opens the possibility of applying similar principles in other imaging fields, both in medicine and elsewhere.

Keywords: ultrasound tomography,full waveform inversion,uncertainty quantification,breast cancer diagnosis,breast cancer screening,supercomputing
Hazardous Pesticide Bans and Early-Life Health Outcomes (PESTBAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: SIGNED

Farm to Fork strategy aims to reduce hazardous pesticide use by fifty percent by 2030 to help achieve a climate neutral Europe but it is still an open question whether potential benefits of the proposed strategy can outweigh its costs. Therefore, it is crucial to examine if eliminating harmful pesticides can provide significant health improvements and to weigh these health benefits against the potential economic costs of adopting safer but less effective plant protection practices. The project's main objective is to examine the impact of hazardous pesticide bans on early-life health and economic outcomes in Türkiye. PESTBAN will expand the state-of-the-art knowledge on economics of pesticides in several aspects. First, it will contribute to previous studies on pesticides and health by comparing early-life health outcomes within agricultural areas as they switch from hazardous pesticides to safer alternatives. Second, the project will contribute to existing literature on economics of pesticide bans by monetizing the health gains from harmful pesticide bans and comparing these benefits to economic impact of bans on agricultural production areas. The project has the potential to encourage adoption of stricter regulations on hazardous pesticides by highlighting the health benefits of pesticide bans. Specific aims of the project include (1) data collection on hazardous pesticide use and established bans in Türkiye, agricultural production and crop prices; acquisition of individual health data from national birth registry and national health surveys; (2) empirical analyses to investigate economic and health effects of pesticide cancellations established between 2005 and 2015; (3) implementation of models from soil and water sciences to evaluate the pollution potential of groundwater sources and to provide insights on whether hazardous pesticides can persist in the environment and continue to threaten the public health in surrounding regions long after the imposed bans.

Keywords: economics of agriculture,infant health
Development of a marketable adjuvant candidate for vaccine applications (ADJUVACCINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

ADJUVACCINE seeks to leverage a breakthrough made in the ERC-2016-STG-716878 project to validate a synthetic technological platform for the scalable production of identified optimised saponin adjuvants for improved cost-effective vaccines. We have developed in the laboratory potent, safe, stable, and streamlined adjuvant leads that surpass the QS-21 natural product adjuvant, leading to patent applications and the interest of Pharma. In this PoC project, we aim to exploit our synthetic saponin technology to produce adjuvant/vaccine candidates at scale that outperform existing products more cost-effectively, lowering the risk profile of the commercialisation potential, while also achieving valorisation outcomes for market entry. The goal is to demonstrate the scalability of our innovative adjuvant technology and select an optimal adjuvant candidate in advanced preclinical settings for entering the vaccine market via spin-off formation following proper IPR strategy implementation and attraction of key investors/partners. The breakthrough innovation potential of ADJUVACCINE lies in the exploitation of this adjuvant platform for large-scale production and selection of the best candidate lead for application in vaccines against various diseases, improving the available vaccine solutions. The high purity and excellent chemical control of our synthetic technology versus the heterogeneous natural product adjuvants, as well as its streamlined, scalable nature and low-cost profile are unique attributes of our platform that will be valorised herein, making it a potentially superior alternative to existing vaccine models with less structural definition and costlier timelines. The main objectives are 1) demonstrate our synthetic technology platform for the gram-scale production and selection of a candidate adjuvant lead; and 2) implement valorisation opportunities and verify the potential of spin-off creation by establishing an optimal IPR and public/private funding roadmap plan.
TRAINING IN TRANSLATIONAL PROTOCOLS FOR MINIMAL INVASIVE DIAGNOSIS AND THERAPY IN PANCREATICO-BILIARY CANCERS (TRIP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Romania,Denmark,United Kingdom,Netherlands
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1383723.93
EU funding (EUR): 1383723.93
Participants: 5
Project status: SIGNED

The overall aim of the project is to strengthen the strategic partnership of the University of Medicine and Pharmacy Carol Davila Bucharest (UMFCD), Romania, one of the Widening countries, with two internationally-leading counterparts at the EU level (Region H - Copenhagen University Hospital Herlev, Denmark and University College London, UK), to enhance networking activities among these institutions and to combine their skills and competences in the field of minimal invasive endoscopic interventions in pancreatico-biliary diseases. Translated expertise, in the form of training and educating early-stage researchers (ESR) in the field of minimally invasive endoscopic interventions is needed to increase the number and quality of innovative services at UMFCD and its clinical affiliated hospitals. The proposal is the result of a long-standing collaboration and joint multicentric research projects performed by the partners of the consortium. Thus, in the past 20 years, there was a sustained clinical research activity in the field of minimally invasive endoscopic procedures, supported by various national and international grants of the key persons involved in the TRIP proposal. One of the key WPs of the TRIP proposal is represented by a multicentre protocol for a research project on pancreatic organoid cultures derived from endoscopic ultrasound guided fine needle biopsy (EUS-FNB) specimens with consequent pharmacotyping, used for personalized therapy of pancreatic cancer patients. The project partners will thus transfer their expertise to UMFCD with an emphasis on PhD students and ESRs. This knowledge transfer and capacity building will be achieved through joint research activities and academic collaboration, enhanced staff mobility, education and training activities, workshops, summer schools, and dissemination events. Last, but not least, one of the concrete deliverables of the TRIP proposal is represented by the upgrading of the research management unit at UMFCD.

Keywords: training,pancreaticobiliary diseases,pancreatic organoids
SR - the next generation display technology that empowers users to naturally and intuitively work, play and communicate in 3D - without wearables (Simulated Reality)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3507500.0
EU funding (EUR): 2450000.0
Participants: 3
Project status: CLOSED

Dimenco builds Simulated Reality technology, a revolutionary new form of spatial computing that combines lenticular light-field display technology, computer vision, integrated sensors and image processing algorithms, to experience realistic 3D objects in a virtual environment seamlessly. Simulated Reality enables touchless interaction with digital objects as if they were real, like in Virtual Reality, but without any wearables. We license our technology to OEMs/ODMs, companies like Acer who just introduced to the market their first laptop built on SR. It is the first test end-user product built on the MVP version of our Simulated Reality technology. Dimenco targets end-users in the design and engineering industries, and the tremendous gaming market, followed by the online conferencing market. Originating as a Philips spin-off, Dimenco now has a team of 41 inventors, HW&SW engineers, game developers and business managers who push the boundaries of technical possibilities.

Keywords: 3d autostereoscopic display,holographic visualizations
Welcoming immigrants in Central and Eastern Europe: lessons from Russia's invasion of Ukraine (WICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Latvia
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1996386.25
EU funding (EUR): 1996386.25
Participants: 1
Project status: SIGNED

The negative attitudes towards immigration in Central and Eastern European (CEE) countries were on clear display during the 2015/2016 immigration crisis, particularly in the Visegrád Group countries, but also in the Baltics. Against this backdrop, the overwhelming support for Ukrainians fleeing the war in CEE has come as a surprise to many. It has highlighted the huge inequalities in the treatment of Ukrainians vs. other third country asylum seekers and clearly revealed conditionality of migration and integration systems as well as their potential for change. While there have been countless examples of populist leaders being able to successfully stoke hostility towards immigrants, there is little evidence to indicate what can systematically decrease anti-immigrant sentiments in CEE on such a broad scale. Making use of the unique historical conditions, the project draws from scientific disciplines often overlooked in research on attitudes towards migrants (memory studies, history, security studies, political science, behavioural economics, communication etc.) aiming to generate an original understanding of societal attitudes that go beyond ‘xenophobia’ and ‘prejudice’, and raises broader questions about the relationship between structural, political, cultural, economic, ideological, and agential influences on attitudes towards immigration. The project is based on case studies of three CEE countries (Poland, Latvia, Hungary) and Italy as a benchmark case. While most previous research focuses on negative narratives surrounding immigration, this project seeks to learn from the experience with Ukrainian refugees in CEE and looks for practical solutions on how to effectively counter the negative narratives. In addition to qualitative research methods, it relies on a novel experimental survey design based on full factorial analysis to test how attitudes are influenced by different characteristics of migrants and different framing (information treatment)

Keywords: migration,migrant reception,xenophobia
Revealing the architecture of replicated human chromosomes by sister-chromatid-sensitive fluorescence in situ hybridisation (MicroChrom)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 284915.66
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

The extremely long DNA molecules encoding complex genomes of higher eukaryotes must be organised inside the tiny volume of cells so that the genetic information can be read, maintained, and propagated across cell generations. Genomic DNA is folded into loops such that contacts between distant DNA elements can mediate transcriptional regulation or assembly of mechanically stiff mitotic chromosomes. Following DNA replication, each chromosome contains two DNA molecules, which interact with each other to support homology-directed repair during interphase and DNA compaction during mitosis. Advances in sequencing technology and super-resolution microscopy have revealed the 3D structure of chromosomes with unprecedented resolution, but conventional methods cannot distinguish between the identical sequence present in replicated sister-chromatids. The Gerlich lab has recently developed a new sequencing-based technique termed sister-chromatid-sensitive (scs)Hi-C, which allows the discrimination of intra- from inter-molecular contacts in replicated chromosomes. However, scsHi-C can only inform on interaction probabilities and does not reveal the actual 3D structure in single cells. Therefore, the aim of my proposed project is to establish a sister-chromatid-sensitive fluorescence in situ hybridisation (scsFISH) method for the highly multiplexed and automated detection of the 3D architecture of replicated genomes within individual cells. The ring-shaped cohesin complex is a key regulator of chromosome structure by forming loops within DNA molecules and by linking sister-chromatids. By depleting cohesin core subunits/regulators, I will use scsFISH to understand how cohesin structures replicated chromosomes. I will further investigate how sister-chromatid conformation influences the efficiency of homology-directed repair at double-strand breaks. My project will hence provide insights into the organisation of replicated genomes, with important implications for genomic integrity.

Keywords: sister chromatids chromatin fiber tracing fluorescence microscopy chromosome conformation dna repair