Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Crosstalk of Metabolism and Inflammation (CMIL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-09-30
Duration (months): 66.0
Total project cost (EUR): 1701011.0
EU funding (EUR): 1701011.0
Participants: 1
Project status: CLOSED

Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation represents a functional rheostat that shapes tissue damage and disease. Here, I propose to analyse the metabolic and inflammatory processes in a mouse model of chronic viral hepatitis. I chose this model to explore the inflammatory rheostat because the liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Cutting-edge technologies including deep sequencing, quantitative proteomics and metabolomics will let us create longitudinal multi-dimensional maps of virus-induced alterations. Paired with immunological, virological and pathological analyses, I expect to identify novel regulatory nodes between metabolism and inflammation. Within our systems-wide experiments and supported by preliminary results, we will specifically focus on the immunomodulatory roles of the metabolite bile acids and oxidative metabolism. These as well as other candidates will be investigated by genetic and pharmacological perturbations in cell culture and in mouse models. Bioinformatics integration of the orthogonal profiling kinetics is expected to reveal novel properties of the molecular networks mediating between metabolism and inflammation. This proposed cross-disciplinary approach aims to improve our understanding of the crosstalk of metabolism and inflammation. The results of this project may be relevant to viral hepatitis in man and bear broader implications for other inflammatory diseases.

Keywords: chronic viral infection,hepatitis,lymphocytic choriomeningitis virus,lcmv,inflammation,liver,metabolism,metabolites,interferon,bile acids,crosstalk,systems biology
NanoMaterials Enhanced Membranes for Carbon Capture (NanoMEMC2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Norway,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: International Cooperation with South Korea on new generation high-efficiency capture processes (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 4990816.25
EU funding (EUR): 4990815.25
Participants: 12
Project status: CLOSED

Membrane separation processes can be applied to many capture processes from Pre-Combustion ( CO2-H2 / CO2-CH4 separation) to Post-Combustion (CO2-N2) and Oxyfuel (O2-N2) and are generally endowed with high flexibility and potentially low operative costs with respect to other capture methods. However the current materials are still lacking of separation performance and durability suitable for an efficient and economically feasible exploitation of such technology. The Project NANOMEMC2 aims in overcoming the current limitation focusing on the development of innovative CO2 selective membranes with high flux and selectivity suitable for application to both Pre and Post-combustion Capture processes. To that aim nanocomposite or mixed matrix membranes will be considered with particular focus on facilitated transport mechanisms promoted by carrier attached to the polymer or the filler. Graphene based nanosheets and cellulose nanofibres will be studied in detail considering their possible modification to improve polymer compatibility and affinity with CO2. A new generation of Facilitated Transport Mixed Matrix ( FTMM) membranes for CCS applications will be developed with increased CO2 flux and selectivity beyond the current target for industrial deployment of carbon capture membrane technologies

Keywords: facilitated transport membranes,gas separation membranes,process simulation,pre and post combustion carbon capture
The Implantable Subcutaneous String Defibrillator, an innovative subcutaneous cardioverter defibrillator for a new paradigm in cardiac rhythm management. (ISSD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2018-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sudden Cardiac Arrest (SCA) is a life-threating heart condition and one of the most common causes of death in developed countries claiming more than 350,000 lives per year in Europe2. There are currently two different implantable technologies to prevent SCAs: 1) Transvenous Implantable Cardioverter-Defibrillators (T-ICDs), which are implanted with wires that snake through veins into the heart; and 2) Subcutaneous Implantable Cardioverter-Defibrillators (S-ICD), which also have generators and leads but avoiding leads within the heart. However this solutions pose many drawbacks such as major complications to the vascular system, replacement needs, aesthetical and comfort impacts, complex implantation procedures and cyber-security issues. The ISSD™ introduces a new dimension in subcutaneous ICDs. It is a totally integrated device fully inserted subcutaneously, with no leads within the heart, thus remaining the vascular system untouched. It is a wireless rechargeable device, halving replacement rates when compared to current technologies and it is totally seamless and integrated, so no generators or leads are needed. This makes the device almost invisible and improves patients comfort. It is designed from a cyber-security point of view and can be implanted in a rapid outpatient procedure (20 min on average). So far, we have invested €8M which have helped us to ensure its robustness and efficiency and move into the commercialisation stage. To further develop the ISSD™, overcome market barriers and deploy it at a European and global level we need a further investment of €3M which will allow us to carry out clinical trials and set up a solid EU value chain able to meet the large demand expected during the first years of commercialisation. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of the ISSD™ and its market uptake.

Keywords: ventricular fibrillation,defibrillator,heart,disease,subcutaneous
Combinatorics of Networks and Computation (CONNECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,Spain,Spain,Spain,Italy,Spain,Belgium,Czechia,Canada,Chile,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-08-31
Duration (months): 68.0
Total project cost (EUR): 382500.0
EU funding (EUR): 324000.0
Participants: 14
Project status: CLOSED

Networks are present in our lives in numerous different environments: to name just a few, networks can model social relationships, they can model the Internet and links between web pages, they might model the spread of a virus infection between people, and they might represent computer processors/sensors that have to exchange information. This project aims to obtain new insights into the behaviour of networks, which are studied from a geometric and computational perspective. Thereto, the project brings together researchers from different areas such as computational geometry, discrete mathematics, graph drawing, and probability. Among of the topics of research are enumerative problems on geometric networks, crossing numbers, random networks, imprecise models of data, restricted orientation geometry. Combinatorial approaches are combined with algorithms. Algorithmic applications of networks are also studied in the context of unmanned aerial vehicles (UAVs) and in the context of musical information retrieval (MIR). The project contains the work packages: “Geometric networks”, "Stochastic Geometry and Networks", “Restricted orientation geometry”, “Graph-based algorithms for UAVs and for MIR”, and “Dissemination and gender equality promotion”. The project connects researchers from 14 universities located in Austria, Belgium, Canada, Chile, Czech Republic, Italy, Mexico, and Spain, who will collaborate and share their different expertise in order to obtain new knowledge on the combinatorics of networks and applications.

Keywords: network,geometric graph,randomness,algorithms,musical information retrieval
MacroAutophagy and Necrotic Neurodegeneration in Ageing (MANNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Greece
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2254109.0
EU funding (EUR): 2254109.0
Participants: 1
Project status: CLOSED

Necrosis contributes critically in devastating human pathologies such as stroke, ischemia, and age-associated neurodegenerative disorders. Ageing increases susceptibility to neurodegeneration, in diverse species ranging from the lowly nematode Caenorhabditis elegans to humans. The mechanisms that govern necrotic neurodegeneration and its modulation by ageing are poorly understood. Autophagy has been implicated in necrosis and neurodegeneration, both with pro-survival and a pro-death roles. Autophagic flux declines with age, while induction of autophagy enhances longevity under conditions such as low insulin/IGF1 signalling and dietary restriction, which extend lifespan across diverse taxa. Our recent findings indicate that organelle-specific autophagy, including mitophagy, pexophagy and nucleophagy, is an important, evolutionarily conserved, determinant of longevity. We propose to dissect the molecular underpinnings of neuron vulnerability to necrosis during ageing, focusing on cargo-specific macroautophagy. To this end, we will implement a multifaceted approach that combines the power and versatility of C. elegans genetics with advanced, in vivo neuronal imaging and microfluidics technology. Our objectives are fourfold. First, we will monitor autophagic flux of organellar cargo, during neurodegeneration, under conditions that alter lifespan and identify mediators of organelle-specific autophagy in neurons. Second, we will conduct genome-wide screens for modifiers of age-inflicted neurodegeneration. Third, we will interrogate nematode models of human neurodegenerative disorders for organelle-specific autophagy and susceptibility to necrosis, upon manipulations that alter lifespan. Fourth, we will investigate the functional conservation of key mechanisms in mammalian models of neuronal necrosis. Together, these studies will deepen our understanding of age-related neurodegeneration and provide critical insights with broad relevance to human health and quality of life.

Keywords: autophagy,c elegans,dietary restriction,mitophagy,microfluidics,multi photon imaging,necrosis,neurodegeneration,nucleophagy,pexophagy
Recombination in Organic Photovoltaics: Impact of Morphology and Long-Range Non-Equilibrium Transport (ReMorphOPV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland,Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-15
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 173857.74
EU funding (EUR): 173857.2
Participants: 2
Project status: CLOSED

The global transition towards clean energy requires new ways to generate electricity. One promising approach are organic bulk heterojunction (BHJ) solar cells. These devices are based on a phase-separated network of two organic materials and hold the potential to make solar power cheap and sustainable. However, there is still a lack of fundamental understanding in key areas. One important open question concerns the charge recombination. Although identified as main loss mechanism in BHJ solar cells, its underlying principles remain mysterious. ReMorphOPV comes to address these limitations by developing a new recombination model. The basic hypothesis is that a successful theoretical description must properly consider two key features of a BHJ blend: the complex nanoscale morphology and the dispersive type of charge transport. To account for both aspects, ReMorphOPV will make use of extensive kinetic Monte Carlo simulations with high spatial and temporal resolution. The proposed numerical approach includes most realistic assumptions on the nanostructure (domain size, phase purity, molecular miscibility etc.) and previously overlooked phenomena of charge transport, namely the non-equilibrium and long-range motion of carriers. The predictions of the simulations will be validated by experiments on different prototype material systems. A feedback loop between experiment and numerical model will be initialised to refine the theoretical description and define new parameterisations of the recombination rate that enable easy dissemination to other researchers. With such a model at hand, it will be possible to find design rules for organic solar cells with minimised recombination losses even at large thickness. These results are of great relevance for the photovoltaics community and will help to reinforce Europe's world-leading position in renewable energies.

Keywords: organic photovoltaics,organic solar cells,bulk heterojunction,morphology,recombination,charge transport,numerical modelling,kinetic monte carlo method
Center of Excellence in Combustion (CoEC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Switzerland,Greece,Bulgaria,France,France,Netherlands,United Kingdom
Call: Centres of Excellence in exascale computing (H2020-INFRAEDI-2019-1, 2019)
Start date: 2020-10-01
End date: 2023-12-31
Duration (months): 39.0
Total project cost (EUR): 5644531.25
EU funding (EUR): 5644531.25
Participants: 11
Project status: SIGNED

The Center of Excellence in Combustion (CoEC) is a collective effort to exploit Exascale computing technologies to address fundamental challenges related to the simulation of combustion systems. The CoEC vision is aligned with the decarbonization goals of the European power and transport sectors and the European roadmap to achieve net-zero greenhouse gas emissions by 2050. The consortium is composed by leading institutions in the fields of computational combustion and High-Performance Computing. It promotes a core of scientific and technological activities aiming at extending the state-of-the-art in combustion simulation capabilities through advanced methodologies enabled by Exascale computing. These advances will increase the TRL of representative codes from the EU combustion community. Selected Exascale Application Challenges are used to create demonstrators and validate the project achievements. The most ready technologies will be the basis of a service portfolio to support the academic and industrial activities in the power and transportation sectors. This will eventually increase the EU competitiveness and leadership in power and propulsion technologies.

Keywords: combustion,exascale,alternative fuels,simulations,decarbonisation,services
Novel Drilling Technology Combining Hydro-Jet and Percussion for ROP Improvement in deep geothermal drilling (ORCHYD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Greece,China,Norway,France,France,United Kingdom
Call: Advanced drilling and well completion techniques for cost reduction in geothermal energy (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 4350596.79
EU funding (EUR): 3999945.0
Participants: 7
Project status: SIGNED

Deep geothermal reservoirs are being targeted for renewable energy supply worldwide. However, while international research efforts are stepping up to the challenge of overcoming the low efficiency of heat recovery from depth to the surface, the showstopper remains the slow drilling speed provided by the conventional rotary system in deep hard rocks (> 4 km). Deep drilling requires long drilling times, often resulting in unacceptably high initial investment. ORCHYD’s new drilling technology will increase hard rock drilling rates from the current range of 1-2 m/h up to 4-10 m/h. The novelty is to combine two, previously separate, mature technologies: High Pressure Water Jetting (HPWJ) and Percussive Drilling, in a system customised for hard rock geothermal reservoirs to depths of 6 km. Planned experiments and solid-fluid coupled models designed to reveal the critical fragmentation mechanisms under in-situ stress conditions will be used to design, build and validate, with pilot drilling tests, the new system for field operations. The hybrid development requires optimisation of: i) release of high stress concentrations on the hole bottom while drilling, ii) slotting circumferential relieving grooves on the hole bottom using HPWJ (up to 200 MPa), iii) in-hole production of the HPWJ using a down-hole pressure intensifier activated by the drilling vibrations, hence damping out harmful drilling system vibrations and iv) an advanced down-hole percussive rotating mud hammer for drilling to derive the maximum benefit from the modified bottom-hole stress regime. ORCHYD will decrease the drilling cost by 65% in hard rock sections. This will result in 30% reduction of the total cost of deep geothermal well construction. In addition, the new coupled Intensifier-HPWJ-Hammer system has the potential to drill and steer multi-lateral wells which greatly increase thermal connectivity, are cheaper, use far less water and are more controllable than conventional fracking stimulations.

Keywords: hard rock,stress release,down hole pressures,cutter insert,bit rock interaction,hammer,high pressure jet,nozzle,kerf,intensifier,computational mechanics,fluid solid coupling,fdem
GROW Observatory (GROW)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Innovation actions
Countries involved: Austria,Italy,Austria,Spain,Ireland,Belgium,Greece,Hungary,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Demonstrating the concept of 'Citizen Observatories' (H2020-SC5-2015-two-stage, 2015)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 5379290.58
EU funding (EUR): 5096919.64
Participants: 21
Project status: CLOSED

The GROW Observatory (GROW) will create a sustainable citizen platform and community to generate, share and utilise information on land, soil and water resource at a resolution hitherto not previously considered. The vision is to underpin smart and sustainable custodianship of land and soil, whilst meeting the demands of food production, and to answer a long-standing challenge for space science, namely the validation of soil moisture detection from satellites. GROW is highly innovative project leveraging and combining low cost consumer sensing technology, a simple soil test and a large user base of growers and plant enthusiasts to contribute individual soil and land data. It is designed to engage primarily individual growers and small-scale farmers across Europe, and to enable them to develop new wisdom and innovative practices through the collective power of shared and open data and knowledge. Citizens contributing data will gain access to the first single-source comprehensive crop and watering advice service for individual and small-scale growers incorporating scientific and crowdsourced information. Moreover, they will develop ‘campaigns’ (coordinated sampling operations) around local needs and issues, to underpin smarter decision-making and implementation of policy objectives. GROW will actively identify and enable new and credible social and business innovation processes, creating potential new services, applications and markets. The outcome will be a central hub of open knowledge and data created and maintained by growers that will be of value to the citizens themselves as well as specialist communities in science, policy and industry. The GROW partnership will connect and scale to globally dispersed communities linked through digital and social platforms, and a wide range of additional citizen associations and NGOs in sustainable agriculture, gardening, food democracy and land management.

Keywords: citizen observation,sensors,crowdsensing,participation,decision support,land,soil,soil moisture,water resource,rural and urban agriculture