Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INNOVATIONS FOR VACCINES AGAINST HELMINTH INFECTIONS – GLYCOSYLATION SIGNATURES OF IMMUNITY (WORMVACS2.0 Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Croatia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 593587.5
EU funding (EUR): 593587.5
Participants: 2
Project status: CLOSED

The WORMVACS2.0 Hop-on proposal aims to address critical gaps in our understanding of protective immunity against helminth infections, with a particular focus on glycosylation, a complex and common posttranslational modification of proteins. Glycans play essential roles in infectious disease biology, such as mediating host-pathogen interactions, contributing to immune effector functions, and regulating host immune responses. Despite the importance of glycosylation in immunity, WORMVACS2.0 currently lacks an in-depth glycosylation analysis of the host’s immune system components - a highly relevant yet underexplored aspect of immunity against helminths that needs to be addressed in support of the development of effective anti-helminth vaccines. To address this gap, GENOS, a global leader in high-throughput glycomics, will join the WORMVACS2.0 consortium to perform comprehensive glycosylation analyses on samples from controlled human helminth infection trials, natural infection cohorts, and animal vaccination models. This will include studying the glycosylation patterns of total serum/plasma proteins, immunoglobulins (IgG, IgA, IgM), alpha-1-acid glycoprotein and complement component 3. The project aims to uncover inter-individual differences, track longitudinal changes, and investigate associations between glycosylation patterns and clinical, parasitological, and immunological data. The project’s objectives will be achieved through GENOS’ cutting-edge glycoanalytical technologies, which have been successfully applied in large-scale studies across various diseases. The findings are expected to enhance the WORMVACS2.0 consortium’s capacity to develop more effective vaccines by incorporating insights into glycosylation and its role in protective immunity, thereby aligning with the work programme’s goals of advancing vaccine research for neglected tropical diseases.

Keywords: glycomics,antibodies,innate immunity,multi omics
5G NTN SATELLITE DIRECT TO MOBILE IN-ORBIT DEMONSTRATION (5NETSAT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Luxembourg
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

OQ Technology proposes a European 5G non-terrestrial network (NTN) satellite direct-to-mobile communication service based on the 3GPP standards. Through this grant, OQ Technology intends to demonstrate the proposed solution through an In-Orbit Demonstration satellite mission providing SMS and emergency services for direct-to-mobile based on the 5G 3GPP standards. This shall allow OQ Technology to be the first European player to make a huge social impact in connecting the unconnected globally and saving millions of lives by enabling satellite-based SMS and emergency services on the smartphones, for the public. OQ Technology has a proven expertise in space and telecommunications, demonstrated through its track record of eight successful missions in the past three years. OQ Technology will leverage and improve its existing intellectual properties of its 5G protocol stack implementations for NTN to enable the proposed services; with its divergent multi-cultural team of 30 members coming from 14 different ethnicities and nationalities.

Keywords: direct to mobile,5g non terrestrial networks,satellites,emergency sos,sms over satellites,3gpp
SOLUBOARD – THE WORLD’S FIRST FULLY RECYCLABLE, WATER-SOLUBLE AND BIODEGRADABLE PRINTED CIRCUIT BOARD SUBSTRATE MADE FROM NATURAL FIBRES (JivaSoluboard)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2300000.0
EU funding (EUR): 2300000.0
Participants: 1
Project status: SIGNED

Printed Circuit Boards (PCBs) are crucial components in most electronic devices, contributing to +62M tonnes of e-waste & est. 6M tonnes of CO2 emissions annually from PCB disposal and recycling. PCBs account for up to 42% of the total weight of e-waste and contain valuable metals like copper, aluminium & gold, worth €9–10B annually. Mainstream PCB substrates, FR-4 and CEM-1, dominate +90% of the market, are made from non-degradable materials and toxic substances. Current recycling methods, involving incineration, are value- and energy-inefficient and environmentally harmful, leading to significant economic losses and pollution. Hazardous substances released during processing and disposal of waste PCBs contaminate soil and water, posing serious health risks. Our revolutionary innovation - Soluboard solves these issues thanks to its unique set of properties, being: - Naturally derived – made from natural fibres. - Water-soluble - enabling the recovery of copper and rare & expensive metals. - Non-toxic - containing no toxic substances or Persistent Organic Pollutants. - Biodegradable & compostable - in about 75 days. - Fully recyclable: avoiding incineration of end-of-life PCBs, and improving precious metals recovery up to 50%. Compared to FR-4 (80% of the market), Soluboard has a 67% lower carbon footprint & reduces plastic waste by 590g/m². It enables efficient recycling of precious metals (increases their value by €350 per tonne by avoiding incineration), resulting in a higher price of waste PCBs, energy savings & lower logistic costs. Soluboard is compatible with standard PCB fabrication processes, and has electrical & mechanical properties comparable to market incumbents. Customers are willing to pay a 10–15% premium due to high satisfaction in pilot tests, commercial gains from selling end-of-life PCBs at higher prices, environmental sustainability benefits paired with improved corporate reputation & customer loyalty, and strict ESG legislative compliance.

Keywords: printed circuit board pcb,recyclable pcb,biodegradable pcb,electronics industry
SECONDS: The world’s first AI application to strategically manage emergency services in real time (SECONDS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2122574.0
EU funding (EUR): 2122574.0
Participants: 1
Project status: SIGNED

Emergency Medical Service (EMS) providers face continuously growing demands, necessitating fleet expansion and additional staffing – a traditional yet financially and logistically challenging response. The operational costs for an ambulance can go up to €1.3 million annually, considering capital expenditure, depreciation, and personnel wages - including overtime. Moreover, control room operators, central to public emergency assistance, confront a complex array of tasks with each emergency call. SECONDS is the world’s first AI application to strategically manage emergency services in real time. At its core, the SECONDS application represents a groundbreaking advancement in AI-driven dispatch solutions, methodically designed to ensure optimal regional preparedness and significantly reduced response times. In real-time it calculates the coverage of a region and gives advice on strategic unit placements to maximize the probability that both current and future incidents are reached within the set response time targets. This intelligent system, akin to a sophisticated chess computer, leverages predictions of near-term future scenarios to inform dispatch decisions. SECONDS uses state-of-the-art mathematical theory and models (regression, hierarchical models, machine/deep learning, neural networks) to predict the number, severity, and location of incidents and the emergency’s system state (preparedness) and gives real-time recommendations of optimal emergency vehicle relocation, along with dynamic routing, to reduce the average time to attend a future incident by up to 35%. Automation of the decision-making processes for dispatchers in assigning vehicles to incidents provides an additional level of acceleration and efficiency of control room processes, freeing up dispatchers to provide more focused incident assistance (prior to ambulances arriving) and with high-level oversight ensure optimal system operations as demands change.

Keywords: emergency medical services ems,ambulances,ai dispatch,real time management,dispatching
Upcycling biomass Residue into High-Value Biochemicals (BIOMERGE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Cyprus
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Ecorbio, a cleantech startup established in December 2020, has developed a groundbreaking bioprocess that converts waste biomass into high-quality bio polyols for polyurethane (PU) production, reducing the carbon footprint and costs compared to traditional methods. By utilizing waste biomass from municipal and industrial sources, Ecorbio provides a sustainable alternative to fossil-based materials. Based in Cyprus with support from Gravity Ventures Incubator and national R&D grants, Ecorbio's pilot line processes 1 ton of waste biomass per day. Their patent-pending process offers up to 3 times less carbon footprint and 33% cost savings compared to conventional polyols, attracting interest from major industry players like VITA Group, DOW, and Manali Petrochemicals. Ecorbio's bio polyols are suitable for replacing commercial polyols in applications such as rigid PU foams and thermoplastics and can be integrated into existing facilities, enhancing scalability and reducing setup costs. Ecorbio's process involves converting waste biomass and glycerol-containing compositions into bio polyols through heating and chemical treatments. With a validated Technology Readiness Level (TRL) of 6, the process is prepared for scaling up to an industrial capacity of 2500 tons per year by 2027. The resulting bio polyols feature high hydroxyl numbers, low acid numbers, and low viscosities, making them ideal for PU synthesis. In the €40 billion polyol market, which faces challenges from fossil fuel dependence and environmental concerns, Ecorbio offers a sustainable, cost-effective alternative. The company targets the €2.2 billion biopolyol market for applications in thermal appliances and construction segments, with additional focus on the maritime industry in the future. Support from the EIC Accelerator is crucial for Ecorbio to secure Series A investment, enhance production, expand market presence, and position itself for a successful Series B scale-up.

Keywords: biopolyols,waste valorisation,circular economy
Researching Stereotypes towards LGBTQIA+ Community Members with Multilingual Natural Language Processing (RAINBOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The RAINBOW project addresses the pressing issue of stereotypes and biases directed at LGBTQIA+ individuals online. In an era where digital discourse shapes societal attitudes, it is imperative to address the rising tide of stereotypes targeting queer people. These stereotypes can escalate into hate speech and violence, perpetuating discrimination. RAINBOW's objective is to preemptively counteract these stereotypes, fostering a more inclusive and tolerant online environment. While much research exists on hate speech detection, there is a significant scarcity of initiatives that focus on early intervention to prevent stereotypes from evolving into hate speech and violence. The project seeks to fill this gap by pioneering advanced Multilingual Natural Language Processing (NLP) techniques specifically tailored to recognize and counteract emerging stereotypes and biased narratives (in English, Spanish and Italian). This proactive approach, combined with collaboration across linguistics, NLP, sociology, and LGBTQIA+ studies, offers a comprehensive understanding of the issue and the development of tools to address it effectively. Furthermore, the findings of this project will play a pivotal role in the development of an Educational Toolkit specifically designed to raise awareness about stereotypes and biases directed at LGBTQIA+ individuals. This tool will be tailored for the age group that spends the most time online (16-24 years old), ensuring that the next generation is equipped with the knowledge and understanding needed to foster inclusivity and combat stereotypes in the digital realm. Essentially, the RAINBOW project aligns closely with the objectives of the Work Programme, aiming to establish a safer online environment for LGBTQIA+ individuals while advancing the frontiers of Multilingual NLP technology to combat online discrimination. This research endeavor bears substantial potential in shaping a digital future characterized by greater equity and inclusivity.

Keywords: computational linguistics,natural language processing,social media processing,multilingual,lgbtqia,stereotypes,education
Unraveling the fundamentals of transport across the vapor-liquid interface (InterLab)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499098.0
EU funding (EUR): 1499098.0
Participants: 1
Project status: SIGNED

Transport of energy and particles across vapor-liquid interfaces is central for growth of rain drops in the atmosphere, evaporation from lakes, distillation columns, development of micro/nano-fluidic devices and much more. The objective of InterLab is to develop theory and methods to reproduce evaporation rates from steady-state experiments with water and octane within an accuracy of 10%. Such a theory is needed urgently since the established alternatives overpredict evaporation rates of water by 2-3 orders of magnitude. The core component of this new theory is the local thermal conductivity in the interfacial region. To reach its objectives, InterLab must fill major knowledge gaps in the fundamental understanding of transport across vapor-liquid interfaces. The tensorial behavior of the local thermal conductivity at the interface will be described and the nature of the thermal insulation layer at the vapor-side of the vapor-liquid interface will be understood. Octane and water will be investigated to clarify the role of hydrocarbon chain contributions and hydrogen bonds. The predictions from the new theory will be tested against nonequilibrium molecular dynamics simulations and new evaporation experiments. To be able to distinguish the different transport mechanisms for evaporation and validate the theory, two experimental rigs will be built. The rigs will measure the pressure to an accuracy that is one order of magnitude better than what has been reported in the literature. A computational fluid dynamics model will be used to extract information about the local heat flux across the vapor-liquid interface to achieve sufficiently high accuracy. The overarching goal is to obtain an understanding, a theory, and quantitative agreement from the molecular level to lab-scale experiments.

Keywords: vapor liquid interfaces,evaporation,condensation,theory,experiments
The first European Digital Health Technology Assessment framework co-created by all stakeholders along the value chain (EDiHTA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Denmark,Spain,Belgium,Germany,Poland,Switzerland,United Kingdom,Norway,France
Call: Development and harmonisation of methodologies for assessing digital health technologies in Europe (HORIZON-HLTH-2023-IND-06, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7532870.0
EU funding (EUR): 7532870.0
Participants: 22
Project status: SIGNED

Digital health technologies (DHTs) are expected to improve both the quality and delivery of healthcare services for European societies while ensuring the sustainability of Europe`s healthcare systems. DHTs are also able to collect real-world data and evidence relevant for decision makers. However, the implementation of DHTs implies new methodological challenges to the standardisation of assessment criteria. Existing Health Technology Assessments (HTAs) are unable to capture the real added value of DHTs. EDiHTA will be the first flexible, inclusive, validated and ready-for-use European HTA framework reaching TRL 6-7, allowing the assessment of different DHTs (e.g. telemedicine, mApps, AI) at different TRLs, territorial levels (national, regional and local) and perspectives (e.g. payer, society, hospital). All relevant stakeholders will contribute to its design, development and validation. The digital framework will be piloted in real healthcare settings in 5 major European hospitals and through an open piloting scheme with European DHT developers. The principles of EDiHTA are to 1) promote a holistic approach involving all stakeholders for consensus building at national and European levels; 2) define a common terminology, harmonise and enrich existing HTA frameworks and create an open repository with frameworks, guides, articles and HTA methodologies; 3) optimise assessment processes along the DHT life cycle; 4) follow a multi-stakeholder, multi-domain and modular approach; 5) co-create EDiHTA solutions; and 6) provide a validated and ready-for-use digital HTA framework for DHTs. Next to leading academic groups in HTA research, our multidisciplinary consortium includes HTA agencies, clinics as DHT end-users, technology providers and a patient organisation with links to the broader European healthcare landscape of regulatory bodies, policymakers and payers. EDiHTA will leverage its network to accelerate the market entry of new DHTs for the benefit of European society.

Keywords: digital health technologies,health technology assessment,assessment framework,healthcare systems,digital health,telemedicine,ai,digital transformation,data security,medical devices
Laser-Based Infrared Vibrational Electric-Field Fingerprinting (LIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1881875.0
EU funding (EUR): 1881875.0
Participants: 2
Project status: SIGNED

A biological system’s phenotype and the evolution thereof are mirrored in molecular composition. The complexity of biological samples, however, renders quantitative, multivariate molecular probing challenging, in particular for non-destructive, label-free approaches. Vibrational spectroscopies capture signals from all molecular bonds exchanging energy with an optical excitation, delivering highly-specific optical fingerprints of samples in their native state, to which virtually all molecules contribute. Yet, while infrared (IR) spectroscopies profit from large vibrational cross-sections, technical limitations of IR radiation sources and detection have so far limited their applicability to real-world biomedical settings, in particular in the context of highly absorbing water (ubiquitous in biological samples). The project LIVE aims at harnessing the unparalleled control over light, on the level of individual optical-field oscillations, afforded by femtosecond lasers and nonlinear optics, to overcome current technological limitations and advance IR spectroscopy toward the fundamental limits set by the nature of light and, thus, toward the ultimate sensitivity, specificity and throughput achievable in optical vibrational fingerprinting. To this end, we envisage the development of powerful sources of fewcycle pulses covering the entire IR molecular fingerprint region (500–4000 cm-1) with utmost electric-field waveform stability, and of innovative electric-field sampling techniques capturing nearly all photons emitted by linearly and nonlinearly excited molecular vibrations. The host institution permits immediate validation of these developments for real-world biomedical samples, including, high-throughput vibrational fingerprinting of individual cells in flow cytometry, spectral tissue histopathology and high-resolution, high-sensitivity breath gas monitoring. Thus, LIVE promises direct impact on patients’ health, deeply rooted in basic photonics research.

Keywords: infrared spectroscopy advanced laser physics biomedical optics femtosecond lasers