Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Production of sustainable aviation fuels from waste biomass by coupling of fast pyrolysis with solar energy (Circular Fuels)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Finland,France,Sweden,Austria,Poland,Czechia,Belgium
Call: Technological interfaces between solar fuel technologies and other renewables (HORIZON-CL5-2022-D3-02, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 4997353.5
EU funding (EUR): 4997353.5
Participants: 9
Project status: SIGNED

The Circular Fuels project integrates concentrated solar heat, solar electrical energy, and thermochemical conversion of bio-based waste materials to produce sustainable aviation fuels. Coupling concentrated solar heat with fast pyrolysis to produce sustainable aviation fuels has not yet been achieved and requires technological innovation. Waste wood (A+B) and agricultural residues (straw), listed in the Renewable Energy Directive (REDII Annex IX), will be used as cheap and abundant bio-based waste material feedstocks. The feedstock will be first converted into renewable bio-oil in the new solar assisted fast pyrolysis. The use of solar energy removes the need to burn any fraction of the pyrolysis products to heat the pyrolysis process. The solar pyrolysis will produce valuable by-products, such as biochar, that can improve the economics of the process. The pyrolysis oil will be stabilized and upgraded to reduce the oxygen content to close to zero by slurry hydrotreatment and hydrodeoxygenation. These processes will employ green hydrogen, produced using optimized solar photovoltaic-assisted water proton exchange membrane electrolysis. Finally, the oil will be fractionated into sustainable transportation fuels by distillation. Our main objective is to maximize the fraction of jet fuel. In addition, we will analyze all component fractions suitable as transportation bio-fuel products, such as gasoline and diesel, to maximize the profitability of the concept. The proposed new thermal pyrolysis process pathway is not yet standardized for ASTM D7566 (Standard Specification for Aviation Turbine Fuel Containing Synthesized Hydrocarbons). Therefore, we will perform compatibility and turbine combustion tests for the required standardization and inclusion into ASTM D7566. We aim for a sustainable aviation fuel production price of 1.5 €/kg. We will analyze the sustainability aspects of the technology and give policy recommendations for successful commercialization.

Keywords: sustainable aviation fuels,saf,solar fuels,fast pyrolysis
Mapping and Matching Content Diversity and Bias in EU Online Social Networks (PolarScopEU)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

PolarScopEU proposes an original application, tailored for the context of different EU countries, that will measure and map, in two-dimensional spaces, the polarisation of their online social networks. This tool, to be made available first in Greece, Portugal and Spain, addresses not only the impact that online political communication, and misinformation, is having nowadays on democratic institutions, but also citizens’ unawareness of existing biases in the online political information that they are exposed to. More concretely, relying on automated analyses of Social Media content to assess politicisation levels of multiple key issues, this application will allow its users to: 1) better understand how they place, in terms of the online content that they create and consume, in two major dimensions of political content: diversity and bias; and 2) find out which actors are closer to them when it comes to the politicisation of several important issues (e.g., European Integration, Immigration, Environment). In order to create this application, the PolarScopEU will develop two additional products of extreme value for researchers and organisations to study, and monitor, online political communication. The first one is an innovative tool to measure, using alternative sources of text data, the levels of salience and contestation of different political issues. The second product is a periodically updated database, for each country, with polarisation and issue politicisation scores for an extensive list of national actors, including political parties, news media and other key opinion makers. These products will facilitate the comparison of issue politicisation across countries, time periods, and actors and originate an innovative polarisation index of online political communication in the EU countries.
European Cloud for Heritage OpEn Science (ECHOES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: France,Spain,Finland,Austria,Germany,Netherlands,Belgium,Italy,Greece,Serbia,Ireland,Hungary,Sweden,United Kingdom,Poland,Cyprus,Portugal
Call: A European Collaborative Cloud for Cultural Heritage (HORIZON-CL2-2023-HERITAGE-ECCCH-01, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 24419557.61
EU funding (EUR): 23970598.22
Participants: 51
Project status: SIGNED

ECHOES aims to create the European Collaborative Cloud for Cultural Heritage (ECCCH) as a shared platform for heritage professionals and researchers to access data, innovative scientific and training resources and advanced digital tools co-developed by the heritage community according to their specific needs. ECHOES will bring together fragmented communities of the Cultural Heritage (CH) field, which consists of various actors from different sectors and disciplines, into a new community around the Digital Commons. Going beyond the strict focus on assets and the mere digitisation of Heritage, ECHOES intends to generate a visionary paradigm shift in the CH field. Adopting a holistic approach, ECHOES will also enable digitising the existing knowledge of Heritage objects, whether tangible or intangible. It will create a digital environment enabling collaborative analysis of CH assets, facts, and phenomena. In this environment, actors – humans or Artificial Intelligence – can develop their interpretations, thereby enriching the knowledge of CH and their surroundings. The digital environment proposed by ECHOES will empower users to interact with, manipulate and enrich Digital Twins, leading to new, jointly developed scientific knowledge. The ECCCH built by ECHOES is anchored in the principles of Open Access and Open Science. It thus promotes inclusion and democratises access to knowledge and digital assets, which are understood as public goods by and for all. This digital environment will allow the creation of a new generation of heritage objects, the Digital Commons, which are semantically rich and collectively produced – we see this as “the heritage of tomorrow”. At the end of the project, ECHOES will deliver a single platform to integrate results of EU and national projects on CH. The ECCCH will be sustainable thanks to its inclusive legal entity, which will be created before the end of ECHOES.

Keywords: collaborative cloud,cultural heritage,cultural heritage assets,digital twins,governance,heritage institutions,heritage science,knowledge,ontologies,open access,open science,open source
Education for Responsible Democratic Citizenship (DEMOCRAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Spain,Estonia,Finland,Germany,Poland,Ireland,Belgium,Netherlands
Call: Education for democracy (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2951910.0
EU funding (EUR): 2951909.75
Participants: 10
Project status: SIGNED

EU-society faces four major challenges: the Anthropocene crisis, digitalisation, the pandemic and the Ukraine war and its consequences. All these challenges put at risk the model of liberal democracy, which, of course, has faced similarly internal threats (e.g. political polarisation, right wing extremism, mistrust in scientific research and conspirational beliefs) and external critique (questioning whether plural democracy is the best model to affront societal challenges). Education, and especially Education for Democracy (EfD), shall contribute to the defence and enhancement of democracy. This includes the values and principles encompassed within the UN’s 2030 Agenda and its Sustainable Development Goals. Goal 4.7, in particular, defines that education should promote sustainable lifestyles, human rights, gender equality, promotion of a culture of peace and non-violence, global citizenship and appreciation of cultural diversity. To reinforce the resilience and sustainability of democracy, DEMOCRAT aims, through a participatory approach, to elaborate curricula for EfD based on a framework of responsible democratic competences (RDCs), to test them in open, local, innovative learning projects and to develop a toolbox to support the development of transformative EfD practices in the EU and beyond. DEMOCRAT’s ambitious research and innovation programme will provide insights into the points of comparison and contrast in EfD in the EU-member states, and will develop an innovative curriculum framework linking RDCs with digitalisation and sustainability. DEMOCRAT will test and analyse pedagogical practices and material considering its effectiveness for acquiring democratic competences and European identity. It will garner insights into the factors influencing the impact of EfD on public participation through the analysis of European data-sets, with a particular focus on the relation between socio-economic and educational inequalities and political and social participation.

Keywords: education for democracy,civic education,democracy,political participation,sustainability,digitalisation
Artificial RNA regulators to probe, control, and design gene regulatory networks in bacteria (ArtRNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1999913.0
EU funding (EUR): 1999913.0
Participants: 1
Project status: SIGNED

RNA is common to all organisms. Despite its major function as the coding agent for protein synthesis, an increasing number of regulatory roles have been assigned to RNA. In bacteria, small RNAs (sRNAs) constitute the best-studied class of non-coding regulators estimated to control ~20% of all genes in a given organism. Most sRNAs affect gene expression by base-pairing with multiple target mRNAs resulting in either gene repression or activation. sRNA regulators are modular, versatile, and highly programmable, and thus have gathered momentum as control devices in synthetic biology and biotechnology. My group has recently established artificial sRNAs as a potent genetic tool to screen, detect, and characterize microbial phenotypes. We have now extended this method by a novel sequencing approach, called LIGseq, allowing us to map sRNA-target interactions at the population level and in a high throughput manner. We have further shown that sRNAs expressed from the 3’ untranslated regions (UTRs) of mRNAs can serve as tuneable autoregulatory elements and thus bear ample possibilities for the design of artificial gene networks. I therefore posit that artificial sRNAs are powerful, yet understudied control elements of the synthetic biology toolbox with largely untapped regulatory potentials. I thus propose to: 1) exploit artificial sRNAs to investigate the molecular principles underlying target selection and RNA duplex formation by bacterial non-coding RNAs, 2) harness the power of artificial sRNAs to study essential gene functions and the mechanisms underlying antibiotic resistance in bacteria, 3) employ 3’UTR-derived sRNAs as programmable feedback devices in synthetic gene regulatory circuits. This combined work will generate the molecular framework to employ artificial sRNAs for synthetic biology applications and shed new light on medically relevant processes, such as antibiotic resistance of microbial pathogens.
Accelerating and mainstreaming transformative NATure-bAsed solutions to enhance resiLIEence to climate change for diverse bio-geographical European regions (NATALIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: France,Netherlands,Spain,Romania,Greece,Latvia,Norway,Belgium,Italy,Lithuania,Iceland,Switzerland,United Kingdom
Call: Testing and demonstrating transformative solutions on climate resilience, mainstreaming nature based solutions in the systemic transformation (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 16311045.25
EU funding (EUR): 15033486.25
Participants: 43
Project status: SIGNED

NATALIE addresses the risks posed by climate change and its impacts and proposes to advance the concepts of “ecosystem-based adaptation” in Europe combined with climate resilient development pathways, as the means for impact driven Nature-Based Solutions (NBS), to accelerate and mainstreaming the adoption of NBS for resilience to climate change, which is also the cornerstone identified in the recent IPCC AR6 WGII Report. NATALIE will deliver innovative and practical innovations in co-creation of solutions and stakeholder engagement, modelling, testing, monitoring and validation mechanisms that will support regions and municipalities to plan and develop adaptation actions bringing along valuable knowledge and experience as actionable knowledge for adaptation and impact-driven NBS. To achieve this goal, NATALIE will develop a transformative NBS booster pack of 25 solutions (innovative actions that address the key six levers for transformative change: (1) socially acceptable, smart and financial innovative solutions; (2) societal, stakeholder and citizen engagement; (3) larger systemic solutions at regional level; 4) monitoring, evaluation and cost-benefit analysis of solutions; 5) pre-feasibility study; 6) evidence-based outcomes and recommendations). The main goal is to accelerate and foster the mainstreaming of NBS, by forming an ecosystem based adaptation for regional resilience. The booster Innovation Package includes innovative technical, modelling and IT solutions (including an innovative NBS knowledge booster and digital twin), governance, policy recommendations at EU and regional level, financing and public engagement transformative solutions. 18 NBS measures will be demonstrated at 8 case studies, in different biogeographical regions of Europe in Greece, Romania, Latvia, Canary Islands, Belgium (Flanders), France, Iceland and Italy (Veneto region), as well as four follower regions in the Balearic Islands, Romania, France and Lithuania).

Keywords: green financing digital twins artificial intelligence resilience assessment co creation and stakeholder engagement citizen science
Development of advanced AI algorithms for remote patient monitoring (Doctomatic)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Current standard of care of remote patient monitoring solutions require painful integrations with medical devices that make the service tough to handle and inoperable at some points. Doctomatic offers an innovative device & condition agnostic AI-powered SaaS platform. By just downloading an app, patients can scan the results from any domestic medical device and automatically provide the data to their doctors. It's a simple to use technology which accelerates access to critical health information guaranteeing optimisation & cost efficacy of patient treatment. Doctomatic’s mission is to both save lives using AI as a preventative healthcare tool whose data is transformed into a personalised early detection system and remove the burden of our saturated healthcare systems by extending the clinician’s reach to the patients’ home. Our technology ensures conditions are detected prior to them worsening and reduces both chronic conditions and associated comorbidities. Doctomatic is seeking Women TechEU funding to further develop and advance its AI algorithms so as to improve its current performance, increase its device reach and impact more patient's lives.

Keywords: remote patient monitoring,empowered citizen,healthcare education,healthcare empowerment
Exploring Cosmic Dawn with James Webb Space Telescope (FIRSTLIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Slovenia
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2086250.0
EU funding (EUR): 2086250.0
Participants: 1
Project status: SIGNED

The cosmic dark ages - when the Universe was filled with neutral hydrogen that was opaque to ultraviolet light - are thought to have ended around one billion years after the Big Bang, when first light sources produced enough energetic photons to ionize the neutral hydrogen. This phase is referred to as the epoch of reionization and is also the era of the first galaxies' formation. However, this is also one of the least understood epochs in the Universe's evolution. When did it start/end? Was it patchy or smooth? How did galaxies reionize the Universe (if they did)? What are the properties of the earliest galaxies? To answer these questions, this proposal will use deep observations of the largest sample of the most powerful cosmic telescopes that will be observed with the James Webb Space Telescope (JWST) right after its launch. Compared to all previous facilities, JWST’s capabilities are dazzling. Its instruments will provide data beyond those yet seen by any astronomer. However, with high power comes great responsibility. Given its limited lifetime, excellent leadership needs to be established. As a key member of the Near-Infrared Imager and Slitless Spectrograph (NIRISS) team with guaranteed time and a member of the Early Release Science program, I am in a unique position to guarantee success of this project. I am proposing to relocate to Europe. JWST's NIRISS instrument is not represented in Europe, and this program will bring immediate and proprietary access to the data. This proposal will (1) determine the timeline of reionization, (2) identify the exact role first galaxies played in this process by studying their ionized bubbles, and (3) determine stellar properties of the earliest galaxies. With an unprecedented facility, the program will undoubtedly bring many exciting discoveries and allow the first look at the details of the Cosmic Dawn.

Keywords: epoch of reionization,gravitational lensing
Targeting SWI/SNF-related chromatin remodelling defects in solid tumours (TargetSWItch)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1499887.75
EU funding (EUR): 1499887.75
Participants: 1
Project status: SIGNED

Recent large-scale genomic profiling studies have uncovered mutations in the SWI/SNF (SWItch / Sucrose Non-Fermentable) chromatin remodelling complex subunits in 20% of solid tumours. Most of these tumours resist to current therapies. To address this highly unmet medical need, it is crucial to determine how to harness vulnerabilities induced by SWI/SNF defects. Recent evidence shows that SWI/SNF influences the DNA damage response and is involved in shaping tumour immunogenicity. Though, whether there is a link between these observations, and whether the latter may be therapeutically exploited is unknown. Further, the impact of SWI/SNF defects on tumour heterogeneity, a major determinant of resistance to treatment, remains unaddressed. I therefore propose to identify and understand synthetic lethal vulnerabilities associated with two selected SWI/SNF defects of unmet need (PBRM1 and SMARCB1), and to further study how the latter can be exploited to stimulate the anti-tumour immune response. By using hypothesis-testing and -generating approaches including high-throughput screening on in-house developed isogenic and non-isogenic models, I will identify and decipher novel synthetic lethal vulnerabilities associated with PBRM1 and SMARCB1 defects. Molecular biology, high-content imaging and in vivo experiments will be performed to study the effects of drugs that cause synthetic lethality, both on intra-cellular signalling and on anti-tumour immune response. I will further characterise the impact of SMARCB1 defects on tumour heterogeneity using single cell sequencing on preclinical models and human tumour samples. Preclinical data will be integrated with tumour profiling and clinical data, and will guide the development of proof-of-concept clinical studies, as I previously did. The overall research program will identify, decipher mechanistically and evaluate clinically novel immuno-oncology therapeutic strategies for selected SWI/SNF-deficient tumours of unmet need.

Keywords: cancer therapeutics chromatin remodelling resistance to treatment precision medicine