Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From the bottom-up: a physico-chemical approach towards 3D nanostructures with atomic-scale control (BottomUp3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1895897.0
EU funding (EUR): 1895897.0
Participants: 1
Project status: SIGNED

It is a long held dream in nanoscience to synthesize materials from the bottom-up with atomic-level control of structure and properties, yet the fabrication of nanoelectronics still relies completely on top-down processing. Innovative schemes for bottom-up fabrication will be realized in this project by developing approaches for area-selective atomic layer deposition (ALD), a technique that has the potential to become the new paradigm of bottom-up processing because of its atomic-scale control. Current work on area-selective ALD focuses on the processing of planar substrates, while emerging developments in nanoelectronics and quantum computing require the fabrication of 3D nanostructured devices. Building on recent innovations in my lab, a multidisciplinary approach to area-selective ALD will be employed which combines vapor-phase dosing of inhibitor molecules as a chemical method and the exposure to directional ions from a plasma as a physical method. Fundamental understanding of the mechanisms of chemical inhibition will be acquired, and a new strategy for physical removal of defects will be developed. These methods will be employed on 3D substrates to enable the fabrication of future device structures. By bringing inhibitor molecules and the directional nature of plasma ions together, new flavors of selective processing will be invented including anisotropic or topographically-selective ALD, which opens up a new direction for the field of area-selective ALD. The synergy between my extensive expertise with in-situ reaction mechanism studies and plasma processing, my leading role in the field of area-selective ALD, and the group’s unique facilities for atomic-scale processing, offers a stepping stone to the long-awaited shift from top-down to bottom-up processing. Moreover, this work will allow for the scaling of electronics down to the single-nanometer level.

Keywords: atomic layer deposition ald,area selective deposition asd,atomic scale processing,surface reaction mechanisms,nanopatterning,plasma surface interaction
Heritage Language Acquisition: The qualitative nature of input and cross-linguistic influence (HeLA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-03
End date: 2024-04-15
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

This project aims to fill important gaps in our existing knowledge of Heritage Language (HL) acquisition, a subfield of bilingualism studies. While most previous research has focused on describing how HLs diverge from their monolingual baselines, the main objective of HeLA is to understand why heritage grammars develop the way they do. To this end, we focus on the severely understudied population of pre-teenage heritage speakers (HSs) of Spanish. While much attention has been paid to the role of input quantity in HL acquisition, relatively little is known about the qualitative nature of that input. This project investigates input quality by focusing on cross-generational attrition: the situation where HSs’ parents might exhibit changes in their L1 use –due to prolonged exposure to a second language and lack of activation in their first language– which get passed on to the next generation of HSs. We will approach this topic in a unique and novel way, namely by including individual analyses of children and their respective parents, and establishing a one-to-one connection between the two. Thus far, the majority of research on heritage Spanish, has been carried out in the context of the US. HeLA offers a valuable contribution to the field by comparing Spanish in two different linguistic contexts in Europe: the UK and The Netherlands. By looking at phenomena that are instantiated differently in English and Dutch –grammatical gender and subject expression– we will gain more insight into the role of cross-linguistic influence from the majority language. We furthermore combine behavioural and online measures of competence to examine whether the type of task brings anything to bear on the participants’ performances. Gaining a deep understanding of the factors that shape heritage grammars is of considerable importance for the maintenance of immigrant languages and cultures, as well as for stakeholders in the public and private sector charged with supporting such efforts.

Keywords: bilingualism,heritage language acquisition,input quality,cross generational attrition,cross linguistic influence,comprehension,production,online processing,spanish,dutch,english
Event Horizon: An Audiography of Transformation (EH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

“Transformational festivals” are popular contemporary platforms for the performance of community arts. These intentional participatory events have become powerful vehicles for transnational cultures motivated to initiate transit from the conditions of late modernity to mindful, humanistic, and ecologically sustainable futures. Held annually in Nevada’s Black Rock Desert and replicated in over 80 events worldwide, Burning Man is widely recognised as a prototype transformational event. And yet, the transformative dynamics of Burning Man are significantly under-researched. This project will correct this paucity though a multi-sited study focussing on Burning Man as a liminal culture and sonorous society. While the ephemeral and polyphonic conditions of this and other transformational event-cultures are obstacles for researchers, an audio-ethnography of Burning Man is designed to evaluate the liminal architecture and transformational logics of this event-centred movement. Developing new understanding of event-sonicity, the fellowship will interrogate this movement occupying the frontiers of change. The ER will develop skills in sound recording, editing and production, with training advancing comprehension of the socio-sonic aesthetics of Burning Man events. Throughout the project, the ER will undertake fieldwork across two signature projects at three unique field sites, and in addition to this audiography, will co-edit with the adviser a journal special issue, produce two journal articles, publish two industry articles, present at two conferences, organise a symposium, and host two industry roundtables. Training in teaching, research and academic administration will provide a career development plan preparing the ER for a permanent academic post. The project will be integral to the consolidation of festive studies, sound studies and event-culture research as connected interdisciplinary fields of research in which the ER and adviser have each made notable contributions.

Keywords: festival,event,subculture,transformation,ritual,sonic culture,audiography
Molecular Ancient Fish Remains Identification (MAFRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-09
End date: 2018-06-08
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

One main issue facing fisheries management is uncertainty regarding how fish populations will respond to changes in fishers’ behaviour or the environment. With fish resources under increasing pressure, accurate, cumulative histories of anthropogenic and environmental change are a key tool in developing effective management policies. Archaeology can help overcome this issue by providing detailed, long-range histories of local inshore fisheries and their exploitation by humans, but only if techniques for the identification and analysis of fishbone are refined. Fishbones are underrepresented in the archaeological literature because they are less stable than other taxa. Identification to species is often difficult or impossible. During my MSc I developed an identification system for fishbone: ZooMS (Zooarchaeology by Mass Spectrometry), based upon protein barcoding. As proteins can be cleaved enzymatically and analyzed by mass spectrometry in a repeatable way, protein barcoding is used widely for quick and inexpensive protein identification. Mass spectra reflect the differences in protein sequence and can therefore be reproducibly linked to a particular protein or fragment. Since I left the lab, this method for fish identification has stalled, despite earnest requests from the community for a robust method. ZooMS uses peptide fingerprinting of collagen as a method for rapid identification of archaeological bone. Identifying masses to peptides of known sequence is required. For mammals, sufficient sequence information is available, but, for freshwater fish, species are highly diverse and few sequences are available. This project will develop biomolecular techniques to overcome these hurdles, creating a database of fish collagen sequences and testing the method at several archaeological sites. With these new techniques archaeologists can provide more accurate histories of fisheries. The results will enhance our knowledge of part of our diet inform fisheries management.

Keywords: archaeology,fish,freshwater ecosystem,protein identification,mass spectrometry,biomolecules,archaeozoology,ancient proteins,ancient dna,zooms,fisheries management,climate change
Regulatory network of G-quadruplex dependent Post-Transcriptional mRNA Operons (PTROs) (G4-PTROs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Many studies of global gene expression focus solely on studying the transcriptome thereby only assessing mRNA abundance. However, transcription is only a single layer of gene expression and recently, the influence of post-transcriptional regulation has become undeniable. Rather underrepresented players in post-transcriptional control are G-quadruplexes (G4s). These stable structures can form guanine tetrads in DNA and RNA via p-p-stacking of several planar arrangements of four guanine bases stabilized by Hoogsteen hydrogen bonds and a central metal cation. Recent reports have pointed to an important regulatory role of G4 motives in key cellular functions including pre-mRNA processing, RNA turnover, mRNA transport thereby suggesting intriguing links to human diseases as cancer and neurological disorders. G4 structures in mRNAs seem to act as signaling components that constitute an own post-transcriptional operon. Recruitment of G4-specific RBPs then determines the ultimate fate of G4-containing mRNAs. Not many RBPs or upstream regulatory factors of G4s have been identified and the functional consequences of these interactions are not known. In this proposal I will address these questions. First, I will identify mRNAs that are differentially translated and/or stabilized in the presence of the G4 specific ligand pyridostatin (PDS), which stabilizes G4 structures. The resulting comprehensive list of mRNAs will be the first data set that provides a mechanistically link of G4 motive regulation. Secondly, I will identify factors in the G4 regulatory network using a genome wide shRNA assay to determine proteins that modulate the stability and/or the translation of G4 motive containing mRNAs. It is important to understand G4 structure-function relationships and upstream regulatory processes as the emerging link between G4 formation and human disease opens up an exciting research direction that has potential implications for therapeutic intervention.

Keywords: rna g quadruplexes,post transcriptional control
SCHEDULING OF EVENT-TRIGGERED CONTROL TASKS (SENTIENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1499941.0
EU funding (EUR): 1499941.0
Participants: 1
Project status: CLOSED

The advances in electronic communication and computation have enabled the ubiquity of Cyber-Physical Systems (CPS): digital systems that regulate and control all sorts of physical processes, such as chemical reactors, water distribution and power networks. These systems require the timely communication of sensor measurements and control actions to provide their prescribed functionalities. Event-triggered control (ETC) techniques, which communicate only when needed to enforce performance, have attracted attention as a mean to reduce the communication traffic and save energy on (wireless) networked control systems (NCS). However, despite ETC’s great communication reductions, the scheduling of the aperiodic and largely unpredictable traffic that ETC generates remains widely unaddressed – hindering its true potential for energy and bandwidth savings. To address this problem, I will take up the following scientific challenges: (1) the construction of models for ETC’s communication traffic; (2) the design of schedulers based on such models guaranteeing prescribed performance levels. To reach these goals, I will employ scientific methods at the cross-roads between theoretical computer science, control systems and communications engineering. I propose to follow a two step approach that I have recently demonstrated: (i) modeling as timed-priced-game-automata (TPGA) the timing of communications of event-triggered control systems; and (ii) solving games over TPGAs to prevent data communication collisions and ensure prescribed performances for the control tasks. I will produce algorithms facilitating the efficient implementation of control loops over shared communication resources and increasing the energy efficiency of wireless NCS by orders of magnitude. The advances will be demonstrated on automotive and wireless water-distribution control applications, showcasing the potential economic impact from the reduction of implementation and maintenance costs on CPSs.

Keywords: event triggered control,symbolic,formal methods for control
Development of Triptycene-Based New Hypervalent Iodine Reagents for Selective Organic Synthesis (TripIod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-04
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The challenge of achieving high selectivities (chemo/regio/stereoselectivity) in organic transformations is still very high. Selectivities are achieved through either covalent interactions involving metals or non-covalent interactions such as hydrogen bonding, halogen bonding or ion pairing involving organocatalysts or enzyme catalysts. Triptycenes are highly promising structures due to their rigidity, internal free volume, electron rich cavities, three aromatic rings opened for π-stacking interactions and the possibility of atropisomerism. We want to exploit their potential of non-covalent interactions in chemo-, regio- and stereoselective reactions by using triptycene scaffolds for the synthesis of iodine-based reagents. The proposed research will focus in utilization of internal free volume for selectivity in reactions to explore selectivity through π-interaction. This process will open up new directions by focusing on the following objectives: (a) synthesis of different iodotriptycenes; (b) oxidation of iodotriptycene to iodine(III) derivatives including polymer-based reagents; (c) development of chiral triptycene-based iodine(III) derivatives; (d) application of the methodology in the flow synthesis of target molecules and (e) training through research and career development of incoming post-doctoral fellow. The proposed methodology has the capacity to make a sound impact on the scientific community, and to change existing protocols in industry. The MSC Fellowship will provide the post-doctoral fellow to strengthen scientific knowledge and enrich skills, innovative ideas, managing skills and to establish himself as an international scientist.

Keywords: chemoselectivity,flow chemistry,hypervalent iodine,stacking,polymer chemistry,regioselectivity,triptycene
NEURONAL SELF-RENEWAL BY ANTIGEN-SPECIFIC TOLERIZATION IN MULTIPLE SCLEROSIS REINSTALLING THE BALANCE BETWEEN INFLAMMATION AND REGENERATION (RESTORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Belgium,Belgium,Netherlands,Netherlands
Call: Clinical research on regenerative medicine (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 5357032.5
EU funding (EUR): 5357032.5
Participants: 9
Project status: SIGNED

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system for which no cure is currently available. It is the leading cause of non-traumatic disabling neurological disease in young adults with more than 500,000 people affected in Europe. As chronic inflammatory processes drive the neurodegeneration, we hypothesize that improved clinical outcome can be achieved by restoring the balance between inflammation and the remaining capacity of neuronal self-renewal. In this context, cell therapy that specifically targets the damaging immune reactions that cause MS, thereby reducing the autoreactive, inflammatory assaults in MS without affecting protective immunity against pathogens and cancer, can be a promising approach to allow for more repair. Recently, we set-up a collaborative network of European centers working in cell therapy (COST Action BM1305). From this, a multidisciplinary team from four different EU countries (B, ES, NL and GER) with two additional partners now aims to safely reach the next level of testing and joins efforts to bring antigen-specific cell therapy for MS to the clinic. Our objectives are to evaluate safety, clinical practicality and demonstrate first proof-of-principle of therapeutic efficacy of antigen-specific tolerance-inducing dendritic cells (tolDC) in MS patients in two single-center clinical trials. All regulatory approvals are already in place. Coordinated patient monitoring and centralized MRI monitoring, including radiological correlates of neurodegeneration, and immunomonitoring will enable us to directly compare results between trials and enable consented biobanking, data safeguarding and accessibility to support future efforts in the field of MS therapy. ReSToRe focuses on the advancement of an innovative cell therapy approach with the potential to improve the lives of patients suffering from MS, a currently untreatable disease. This would represent a breakthrough for healthcare in MS.

Keywords: multiple sclerosis,clinical trials,cell therapy,tolerogenic dendritic cells,immunotherapy
Risk reduction for Building Energy Efficiency investments (EENVEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Italy,Spain,Spain,Italy,Belgium,Belgium,France,United Kingdom
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 1494537.82
EU funding (EUR): 1494537.82
Participants: 11
Project status: CLOSED

EEnvest aims at supporting investors´ decision making process by translating building’s energy efficiency technical requirements into economic indicators. These indicators are in turn used to evaluate financial risks associated with deep renovation investment and to include non-energy benefits in asset evaluation models. EEnvest will allow the financial sector to match the EE investments demand and offer for commercial office buildings located in Italy and Spain. EEnvest will increase financers’, investors’, owners’ and users’ mutual trust, by identifying, quantifying and mitigating technical risks associated to those investments as well as by reducing the cost of credit for lenders through targeted risk reduction actions. EEnvest will develop effective evaluation methods for the technical/financial risk correlation by categorising a number of major technical risks and quantifying their impact on investors´ confidence. Those risks will be i) evaluated exploiting existing databases on building energy efficiency (e.g. DEEP database of Energy Efficincy Financial Institutions Group), ii) organized into investor friendly bechmark track record and iii) transferred on a web-based platform through secured blockchain networks The investment demand and offer will be supported by the EEnvest - search&match investment evaluation web-based platform, integrating building stock evaluation data, both from the technical and the financial side. EEnvest approach will be replicable in more countries and business cases thanks to the standardization of technical/financial due diligence framework for energy efficiency renovation of buildings and to the search&match web-based platform allowing deep renovation investments to be more appealing on the financial market.