Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Histopathologic and Mechanistic Assessment of Angiogenesis Inhibitor Related Toxicities: A Cross-Sectoral, Multi-disciplinary Approach. (ANGIOTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,Netherlands,Switzerland,United States,Germany
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 1762399.0
EU funding (EUR): 1762399.0
Participants: 10
Project status: CLOSED

Inhibition of angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a well established therapeutic strategy against cancer. Inhibitors of angiogenesis have been developed to block tumour growth and metastasis, and a number of these inhibitors are now clinically approved. However, contrary to initial expectations, angiogenesis inhibitors can cause a range of toxicities in patients. AngioTox is a cross-sectoral collaboration in the field of biomedicine, responding to a pressing need to understand mechanisms of toxicity associated with angiogenesis inhibitor treatment. AngioTox is comprised of academic groups, SMEs, a global pharmaceutical leader in angiogenesis inhibitor development, and a large company concerned with monitoring drug modulation of cellular pathways. The goal of this consortium is to facilitate comprehensive histopathologic and mechanistic assessment of angiogenesis inhibitor related toxicities following treatment with the two main class of angiogenesis inhibitor; monoclonal antibodies and tyrosine kinase inhibitors. A combined in vivo modelling and digital histopathology approach will be engaged to comprehensively describe a new AngioTox Safety Panel of toxicologic markers. We will develop automated image analysis algorithms to enable quantification of morphological markers of angiogenesis inhibitor toxicity, and will undertake molecular profiling and ex-vivo studies to gain insight into mechanistic pathways. Specialized secondments proposed within AngioTox will facilitate several opportunities for high-end training of researchers across both industry and academia. Findings from the AngioTox programme may be directly utilised by academic, clinical and industry-based investigators to facilitate improved screening of angiogenesis inhibitor toxicologic parameters, inform clinical drug dosing regimens, facilitate the development of more specific and potent angiogenesis inhibitors, and significantly improve patient care.

Keywords: oncology,anticancer therapy,toxicology
Multifunctional MEdical DIagnostic LASEr System (MEDI-LASE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Germany,Russian Federation
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 1630569.0
EU funding (EUR): 1630569.0
Participants: 3
Project status: CLOSED

MEDI-LASE proposes to perform a joint research programme capitalising on the knowledge and expertise of the partners through exchanges of researchers and transfers of knowledge between research centres at the University of Dundee, Laser Physics and the Institute of Medical Science and Technology and two SME companies with expertise in different aspects of photonics based diagnosis, a manufacturer and developer of state-of-the-art medical diagnostics equipment ASKION GMbH and a Russian developer of integrated diagnostic laser systems LAZMA. The aims are to overcome scientific and technical challenges to the realisation and adoption of a unique multifunctional non-invasive laser diagnostic system. Specifically, new and novel laser sources will be developed and validation of the spectroscopy and complex algorithms required to provide relevant and reliable diagnosis of specific biological conditions. The work will comprise experimental research in the optical analysis of blood and tissue to direct the exploitation of the developed system. The project will draw on technology and expertise from all three partners while training 4 early stage researchers and providing career development opportunities for 4 recruited experienced researchers. Many opportunities for further research collaborations exist between the partners and it is anticipated that MEDI-LASE will facilitate the development of relations to catalyse ongoing long-term collaborations.

Keywords: health sciences
ICT System addressed to integrated logistic management and decision support for intermodal port and dry port facilities (SAIL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,Greece
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-11-15
End date: 2014-11-14
Duration (months): 48.0
Total project cost (EUR): 874774.0
EU funding (EUR): 874774.0
Participants: 3
Project status: CLOSED

The project aims at developing an integrated ICT tool able to support logistic chain of goods flow and all business operations provided in the port and the dry port areas. In recent years maritime traffic flow has been increasing in terms of volume of goods and interconnections with different means of transport, such as railway and road networks. As a matter of fact the available space in all port areas can not follow this growing trend, since ports are usually located close to or within the cities. For that reason in many metropolis available port areas are becoming scarce resources. In order to increase the available space dry ports are often established outside the classical port borders and directly connected via rail infrastructures or roads. In this new terminal operators can leave and/or collect their goods as if they were in the port. Moving the time-consuming processing of containers inland away from congested seaports can speed up the flow of cargo among ships and land transportation networks. Moreover many services such as customs clearance, storage and maintenance of containers can be transferred to the dry port. However, the overall management will become more and more complex, since the two terminals have to be managed as if they were one. The SAIL project will develop a Decision Support System (DSS) and a Discrete Event Simulation (DES) to support the management of port intermodal facilities in a European context. Within this framework, experienced researchers will work on a precise representation, modelling and simulation of the intermodal port. There will be developed an advanced DSS based on cognitive based methodologies using soft computing along with computational intelligence techniques to provide an online strategic decision support though a state-of the-art ICT platform. The research efforts will focus on optimizing the intermodal management between the two terminals to achieve optimal transportation and improving the environmental impact.

Keywords: systems analysis and models development,computer technology,technology
Partnership for Numerical Acoustic Simulation of aero-engines (PARNAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium,United Kingdom,Germany,France
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-06-01
End date: 2014-05-31
Duration (months): 48.0
Total project cost (EUR): 919313.0
EU funding (EUR): 919313.0
Participants: 5
Project status: CLOSED

The PARNAS project (1) focuses on an important industrial application (reduction of aircraft engine noise using optimized acoustic liners designed), (2) investigates fundamental mathematical aspects of the related simulation techniques (FEM, DGM, PUM), (3) builds upon three successful FP5 and FP6 research projects where some technological components have been developed and where the partners have learned to work together, (4) Organizes exchanges between five teams in four countries with extensive expertise and skills in the related domain as researchers, developers and users of the underlying technology. PARNAS aims at developing new techniques (PUM), further validating and enhancing recently introduced techniques (DGM) and deploying existing techniques in industry (FEM).

Keywords: algorithms,engineering mathematics,numerical analysis,computational mathematics,aircraft external noise,turbo-machinery (aero-engine technologies)
Development of an oral anti-norovirus therapy (ORALANTINOROVIRUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 231927.2
EU funding (EUR): 231927.2
Participants: 1
Project status: CLOSED

Often reported in the public press as “Stomach Flu” or “Winter Vomiting Disease”, noroviruses are the leading cause of gastroenteritis in the developed world, with frequent outbreaks in closed environments (e.g. hospitals, schools, etc). Outbreaks in hospitals result in substantial economic losses (&gt;100 million € per year in UK), but more importantly put additional pressures on health care services. With the ongoing influenza virus pandemic, it is essential health care services run efficiently, however the winter seasonal peak of norovirus outbreaks will coincide with that of influenza virus and will undoubtedly have a major impact on hospital facilities. Hence new antiviral strategies against noroviruses are essential, yet there are currently no effective treatments to control these pathogens. This proposal aims to explore the use of a new potential antiviral approach based on inhibitory RNA aptamers. Aptamers are single-stranded nucleic acids selected by robotic procedures to have high affinity for a target molecule and its binding often results in specific inhibition. Norovirus replication is catalysed by viral polymerase which may constitute an attractive target for anti-viral therapy. We will identify aptamers against polymerases from 2 different noroviruses: Norwalk virus, the prototypic human virus, and murine norovirus (MNV), that provides us with cell culture and in vivo systems to study norovirus replication. We will investigate if administration of aptamers in mice prevent establishment of MNV infections in vivo. For an efficient delivery of aptamer RNAs to the intestinal tract we will make use of a newly developed technique reliant on invasive non-pathogenic bacteria that enter intestine cells to express therapeutic RNAs. This approach will constitute a proof-of-principle that a probiotic approach may be effective in controlling norovirus infections in vivo and provide a possible avenue for the control of these important pathogens.

Keywords: virology,molecular biology,norovirus,aptamer,viral polymerase,probiotics
MEDUSA, a Meteorological Decision Support System for Aviation (MEDUSA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Germany
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-08-01
End date: 2014-07-31
Duration (months): 48.0
Total project cost (EUR): 546600.0
EU funding (EUR): 546600.0
Participants: 2
Project status: CLOSED

Weather contributes both directly and indirectly to incidents, accidents, and delays in air traffic and hence derogates safety and efficiency of airport operations. Today, the aviation stakeholders receive their meteorological information from different sources, at different update rates and with different levels of resolution and accuracy, often leading to misunderstandings and even wrong decisions. The goal of the project is to develop a MEteorological Decision sUpport System for Aviation (MEDUSA) to provide adequate information about adverse weather situations to all decision makers in the airport environment such as airports, air navigation safety providers, airlines, and weather services. MEDUSA is a highly interdisciplinary and intersectorial project dedicated to the scientific and technological development of an end-user oriented application in the field of aviation meteorology including a marketing and commercialization strategy. MEDUSA, combining scientific complexity with high requirements on technical robustness, will provide an integrated weather information solution to aviation. Adverse summer weather like thunderstorms and heavy precipitation), and adverse winter weather situations like heavy snow fall, icing and freezing conditions at the airport will be considered. Key for the technical development is the integration of the various meteorological products in a robust, reliable, and real-time operational system with an easy-to-understand visualization to assist end-users in daily decision making. The project is organized in four phases, (i) test of existing algorithms and forecasting modules and selection of best suited algorithms and modules; (ii) development of joint platform MEDUSA; (iii) implementation and test of MEDUSA at the airports Munich, Frankfurt, and Barcelona including end-users’ feedback to improve the prototype; and (iv) dissemination of the results to the scientific and end-user communities and commercialization.

Keywords: environmental physics,air traffic management (aircraft operation),remote sensing,meteorology,web 2.0 applications,data base technologies,thunderstorm
Sex in the Early Modern City: Musical Eroticism in Rome (SEMCMER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-06-16
End date: 2014-12-19
Duration (months): 36.0
Total project cost (EUR): 242121.7
EU funding (EUR): 242121.7
Participants: 1
Project status: CLOSED

This project examines the role of music in Rome in creating, circulating, reinforcing, policing and subverting norms of gender and sexuality. The methods by which sexuality and the erotic are transmitted by music (of any age) are not wholly understood; through this investigation we learn more about the affective nature of music, and how music can be used as a political and cultural tool. The research identifies eroticism in music in secular song, drawing on madrigals as well as a repertory of strophic song that is marginal within the discipline of musicology, and then, with reference to settings of the Song of Songs and to the liturgy of women saints, explores eroticism in sacred music. A key aspect is the examination of how early modern women and men interacted with music and fashioned diverse identities that were distinguished by class, ethnicity, race, region, religion, gender, and sexuality. The project argues that some aspects of the European project originate in early modern history. The project promotes awareness and understanding of diversity in the history of gender and sexualities and responds to European legislation against discrimination. It is vital to make clear the long history of sexual diversity in Europe, and the long history of music’s role in sexualities, as a means to work against discrimination on grounds of sexuality and to support and encourage a healthy attitude to diversity. This project will be carried out in Los Angeles, New York and Cork. The initial stage of data collection and analysis will take 12 months, with the remaining 24 months spent writing and developing a monograph, hosting an international, interdisciplinary conference in Europe and developing advance research training networks.

Keywords: humanities,musicology,history of performance,italian literature,music history
Optogenetic analysis of neural circuits controlling behavior in zebrafish (ZF OPTOGENETICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 177065.2
EU funding (EUR): 177065.2
Participants: 1
Project status: CLOSED

The aim of this project is to understand how behaviours are controlled by neuronal circuits in zebrafish. Genetic methods such as the Gal4-UAS system will be used to express the light-gated cation channel channelrhodopsin-2 and the light-gated chloride pump halorhodopsin in defined neuronal populations. These optogenetic tools permit the stimulation (channelrhodopsin) or inhibition (halorhodopsin) of genetically targeted neurons by light in transparent zebrafish in vivo. Effects of these manipulations on behavior will be examined in forward and reverse behavioral screens. In forward experiments, swimming behaviors evoked by uniform or patterned stimulation of neurons will be analyzed in an unbiased manner. In reverse experiments, the effect of silencing defined populations of neurons will be evaluated in the context of an olfactory discrimination learning paradigm. The identification of defined neuronal populations involved in different behaviours will then serve as the starting point for the anatomical and functional analysis of the underlying circuits. The connectivity of the identified neuronal populations will be examined by anatomical methods and transsynaptic viral tracers. The function of neuronal circuits will be analyzed using 2-photon calcium imaging and electrophysiological methods. This integrated approach is expected to provide novel insights into the principles of information processing in the brain and establish a direct relationship between neuronal circuit function and behaviour.

Keywords: neurophysiology,optogenetics,two-photon,calcium imaging,zebrafish,behavior,channelrhodopsin,allatostatin,halorhodopsin
Phylogeny and ethnobotany: Testing predictive approaches to plant drug discovery in the genus Aloe L. (Asphodelaceae) (ALOE-DIVERSITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 205629.0
EU funding (EUR): 205629.0
Participants: 1
Project status: CLOSED

Dr Olwen Grace has worked at the Royal Botanic Gardens, Kew in the United Kingdom since 2004. She was recognised as a promising young scientist in South Africa where she began her research career in botany, and completed a part-time PhD in Plant Science at the University of Pretoria in 2009. This proposal, ALOE-DIVERSITY, is for a 24-month intra-European career development fellowship at the Pharmacognosy Laboratory in the Department of Medicinal Chemistry, University of Copenhagen in Denmark (host institution). Dr Grace will draw on a range of state-of-the-art molecular, biological, chemical and analytical techniques to produce the first robust phylogeny of Aloe (Asphodelaceae) including 200 taxa representing over a third of the diversity in this speciose genus, and novel chemical and bioactivity data for at least 50 Aloe species representing the phylogenetic diversity of the genus. The interdisciplinary nature of ALOE-DIVERSITY will significantly extend the evaluation of the ethno-guided and phylogenetic approaches to medicinal plant research. Aloe is a particularly appropriate candidate for this study due to the exceptional diversity, ethnobotanical and economic value of species such as Aloe vera L., as well as their medicinal properties and the growing concerns for their conservation. Through ALOE-DIVERSITY, Dr Grace will add new insights into predictive approaches to plant drug discovery and the identification of measures necessary to ensure the sustainable use of Aloe in future.

Keywords: biodiversity,traditional uses,systematic botany,biodiversity characterisation,biodiversity inventory: systematics phylogeny taxonomy,pharmacognosy
Freshwater invasive species in Europe: control, prevention and eradication (FRESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

Invasive species together with climate change are currently the greatest threats to biodiversity worldwide and constitutes a great challenge to scientist, environmental managers, the water industry and the society at pan-European and international levels. Consequently, national and international organizations have defined action plans to control and prevent invasions which are structured into three main axes: (i) control, (ii) prevention and (iii) eradication. The FRESIS project proposes an integrative and multidisciplinary approach to implement these three major axes of action that will contribute towards and enhance the competitiveness of Europe in the management of biological invasions. First, multivariate statistical modelling will be used to identify multiple factors that affect the occurrence and abundance of freshwater invasive species. Second, the artificial-intelligence algorithm GARP will be used to model the ecological niche of freshwater invasive species that are afterward mapped using GIS tools. Spatial modelling is directed to (i) understand the actual distribution of invasive species, (ii) their potential range-of-invasion, and (iii) forecast shifts in geographical range due to global changes. Finally, bioassays will be designed to evaluate an innovative cost-efficient green technology to mitigate biofouling: the BioBullets. The combination of traditional and modern statistical modelling together with ecological niche models and bioassays constitutes an innovative approach to freshwater invasive species and will provide outstanding and unique results regarding the ecology, distribution and eradication of aquatic invasions. I highlight the multidisciplinary aspect of this project requiring abilities in ecology, limnology, geography, statistics and chemical engineering. Given the high ecological and economic costs of invasive species, the project has a strategic impact in Europe, both from scientific, economic and social points of view.

Keywords: freshwater ecology,invasive species,modelling (environmental risks),ecosystem modelling (climate change),zoogeography,ecological niche model,garp,control of chemicals,biofouling,microengineering