Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multiple Impacts CAlculation Tool (MICAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Poland,Greece,Netherlands
Call: Socio-economic research: non-energy impacts and behavioural insights on energy efficiency interventions (H2020-LC-SC3-EE-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-11-30
Duration (months): 38.0
Total project cost (EUR): 1993380.25
EU funding (EUR): 1993380.25
Participants: 7
Project status: SIGNED

There is still significant potential to improve energy efficiency in all sectors and levels where measures can be applied. Facing the often cited “energy efficiency gap”, even the profitable potential is not fully exploited. Highlighting and quantifying the additional values of energy efficiency measures and investments considering the multiple non-energy impacts could help closing this gap and facilitate energy-relevant decisions and policy-making. The project "MICAT – Multiple Impacts Calculation Tool" is coordinated by Fraunhofer ISI (DE) together with the European partners IEECP (NL), Wuppertal Institute (DE), WiseEuropa (PL), E3 Modelling (GR), IIASA (AT) and ICLEI EURO (DE). The goal of MICAT is the development of a comprehensive approach to estimate Multiple Impacts of Energy Efficiency. MICAT will enable analyses at three different governance levels (local, national and EU) to address a broad target group and interested actors. This allows simplified analyses to be carried out on the basis of different data and policy scenarios in order to compare and assess the relevance of the multiple impacts. The project thus sets a sound scientific empirical basis for monitoring Multiple Impacts while providing a publicly available and easy usable online tool (MICATool) which has been developed in a co-creational manner with the respective governance levels. The national and local cases for monitoring Multiple Impacts of Energy Efficiency will be developed further in a broad stakeholder and dissemination approach to set a standard for future reporting on Multiple benefits.

Keywords: energy efficiency,non energy benefits,quantification,tool development,policy recommendations
Multi-sectoral approaches to Innovative Skills Training for Renewable energy And sociaL acceptance (MISTRAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Ireland,Ireland,Ireland,Germany,Ireland,Germany,Belgium,Switzerland,Switzerland,France,United Kingdom,Denmark,Denmark,United Kingdom,Portugal,Portugal,Portugal,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 4210438.32
EU funding (EUR): 4210438.32
Participants: 23
Project status: CLOSED

Europe is at the beginning of a major transition to a low carbon economy and is experiencing substantial growth in the expansion of renewable energy generating capacity. However, parallel to this technological investment, many Member States are witnessing increasing levels of local opposition to individual projects, particularly for wind energy, which is now the cheapest form of energy generation. This has a range of consequences including increased deployment costs/delays, increased regulatory demands, reduced market support and highlights a major social challenge for the energy transition. In response to this, MISTRAL aims to nurture a new generation of researchers who can effectively evaluate the complexity of social acceptance issues facing the deployment of renewable energy infrastructure and propose innovative solutions in a variety of research, government and business contexts. It will do this by fostering a vibrant inter-disciplinary environment to change the way we understand and respond to declining social acceptance of renewable energy infrastructure and engage a wider range of inter-sectoral stakeholders to develop innovative solutions. MISTRAL will also provide an innovative training environment where young researchers can develop advanced skills in research and transferable skills, benefit form a range of diverse secondment experiences and debate current issues with some of the world leading researchers in the field, in order to develop advanced capacities for progressing Europe’s energy transition.

Keywords: renewable energy,energy transition,social acceptance
Influenza Virus - Sugar Interactions, From Glycan Arrays To Better Vaccines (Sugar-Enable)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1441681.0
EU funding (EUR): 1441681.0
Participants: 1
Project status: SIGNED

Our current assays to determine the receptor specificity and vaccine efficiency of influenza A virus fail as they do not represent receptors available in the human upper respiratory tract. The lack of these receptors in our laboratory hosts to create vaccines significantly dampen yields, the resulting mismatched vaccines do not afford proper protection and further drive antigenic drift. The objective of this proposal is to elucidate the functional receptor of human influenza A viruses. By using antigenically drifted viruses, we expect to understand how glycan specificity changes due to immune pressure but it will also lead to the identification of a glycan that is utilized by all human IAV viruses. With this knowledge, better surveillance techniques, culture models and structure-based inhibitors can be developed. Using a novel and sophisticated cell-engineering tool, based on lipidated sugars, we will show functional glycan receptor usage. In addition, I will create cell lines in which human influenza A vaccine viruses grow to high titers without adaptation, thus providing superior protection. To achieve this goal, I propose to enzymatically synthesize complex glycans (AIM 1), including sialic acid modifications that are found on the respiratory tract epithelial cells of humans and other IAV hosts. Several enzymatic methods and glycan array tools are in place, and thus the chance of success is high. I already set-up preliminary methods for the use of lipidated N-glycan structures and extensive knowledge on SEEL is present in the department (AIM 2). For creating super vaccine producing cell lines I will use genetic approaches that previously have shown to be successful (AIM3). The systems dealing with sugars enabling function, either for infection or vaccine research, I term sugar-enable, will provide new endeavors to create glycan-analog inhibitors and will bring us steps closer to better vaccines.

Keywords: sialic acid,influenza,n glycan,hemagglutinin,receptor specificity
Engine Mounting System (EMS) for Ground Test Turboprop Engine Demonstrator (EVIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France
Call: Engine Mounting System (EMS) for Ground Test Turboprop Engine Demonstrator (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-07-04
End date: 2021-07-03
Duration (months): 60.0
Total project cost (EUR): 570750.0
EU funding (EUR): 399525.0
Participants: 2
Project status: CLOSED

In aircraft, one of the primary sources of vibration is the power plant. Engine vibration could lead to unnecessary expenses for replacing damaged components, cabin noise, crew and passenger discomfort, and structural fatigue. Hutchinson is the major supplier of aircraft main Power plant and APU Vibration Isolation Systems. The “Engine Vibration Isolation Systems – EVIS” project main objective is to achieve improved engine mounting system in terms of technology and associated process enabling higher level of comfort for passengers. Throughout all the proposed developments a dedicated Cost and weight reduction optimization approach will be implemented so as to enable improved performances in comparison to existing engine mounting system. So as to provide an innovative, lightweight, low-cost EVIS for the related TP Demonstrator engine, Hutchinson proposes to carry out the expected work for two distinctive concepts: • Concept 1: “Cost efficiency concept” based on the adaptation of existing engine mounts, • Concept 2: “Full technical concept” based on specifically developed engine mounts. Both Concepts will be investigated through the same usual V-shape approach for “systems integration” as detailed below: • Establish technical specifications of the engine mounts • Use and adapt/tune if necessary existing engine mounts for the first delivery • Analyze first test campaign results to optimize the EVIS design • Manufacture and deliver optimized EVIS • Analyze second test campaign results Hutchinson will then fully contribute through the above whole process to assist the Topic in evaluating and selecting the most efficient and effective engine suspension system for the TP Demonstrator engine.

Keywords: engine vibration isolation systems,engine mounting system,turboprop engine,vibration isolator,elastomeric mounts,torque restraint system
Reasonable Doubt: An epistemological and psychological approach (ReaDoubt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-04-20
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The purpose of this research is to shed light on the nature and dynamics of doubt and confidence in complex epistemic decision-making, through a study of the notion of reasonable doubt. While doubt is considered a rational virtue, waiting until complete certainty before accepting and acting upon a given hypothesis is unreasonable in many contexts. Given some evidential support for the hypothesis, the threshold beyond which acceptance rather than doubt is the reasonable option seems to depend on the decisional context (particularly the cost of a possible error): jurors in criminal trials should thoroughly consider alternative scenarios before convicting a defendant; doctors or policy-makers, however, may have to take action upon less strongly confirmed hypotheses, depending on the relative costs and benefits of action/inaction. Such a decision-theoretic view of reasonable doubt relies on the assumption that the consequences of an hypothesis are exogenous to the rational evaluation of its evidential support: one first updates one’s degree of belief in view of the evidence, and then assesses whether, given the context, the hypothesis is beyond reasonable doubt (i.e. should be accepted and acted upon). But is it the case that agents’ degrees of confidence in a hypothesis, and their weighing of various pieces of evidence, are impermeable to the decisional context? Is the juror’s actual belief independent from her having to bring a consequential verdict? This research aims to study the epistemological norms of reasonable doubt, taking account of the psychological reality of the agents’ reasoning. The main objective of the fellowship is to develop an original empirical research programme, testing the effects of the consequentiality of epistemic decisions on reasoning. This interdisciplinary project requires the candidate, an expert philosopher, to acquire experimental skills and knowledge in psychology, under the supervision of a specialist in the psychology of reasoning.

Keywords: reasoning,belief,doubt,evidence,confirmation,acceptance,testimony,decision making,juror,action,argumentation,verdict,expertise,epistemic trust
Development of a multiscale modeling strategy to decipher how hybrid DNA/RNA triplexes and G-quadruplexes affect gene expression regulation (HoogsCG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This proposal concerns the study of non-canonical interactions in nucleic acids. These interactions, also known as non-Watson-Crick base pairing, involve single or multiple DNA or RNA strands and are increasingly recognized as having a variety of essential roles in replication forks, telomeres, and gene regulation. Since these processes occur on spatial and time scales beyond the reach of current computational capabilities, we propose to develop an innovative coarse-grain approach to describe them. This approach will tackle an important and yet unmet challenge - the correct description of non-canonical interactions at near-atomic resolution in large-scale nucleic acids. The model will be derived from exhaustive classical all-atom molecular dynamics simulations and will be validated against experimental observables including nuclear magnetic resonance spectroscopy and small angle x-ray scattering. It will be used to describe non-canonical interactions – including Hoogsteen base pairs, which are the building blocks of triplex and quadruplex structures – and will incorporate the effects of epigenetic marks on DNA. The model will enable the description of the sequence dependent mechanical properties of guanine quadruplexes and triplex folds on temporal and spatial scales beyond the reach of current methods. As such, it will allow us to investigate the formation and dynamics of long triplex hybrids of DNA and RNA, the behaviour of long-non-coding RNAs interacting with naked DNA, and the effects of non-canonical interactions in systems relevant to chromatin. Thus, this model will be useful to predict and understand the molecular bases of fundamental open questions in biology and has a potential impact in molecular medicine and the pharmacological industry. Overall, this approach will provide an invaluable theoretical tool to describe nucleic acid structures and dynamics, contributing to the description and prediction of a wide range of genetic and epigenetic processes.

Keywords: computation biophysics,coarse grain modelling,hoogsteen base pairs,non coding rna,g quadruplex,rna triplex
Conservation impacts of hybridization and introgression in symbionts: Measuring the magnitude and role in shaping eco-evolutionary variables (INTROSYM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 263732.16
EU funding (EUR): 263732.16
Participants: 2
Project status: SIGNED

Despite their diversity, relevance, and conservation status, fundamental aspects of the Ecology, Evolution, and Conservation Biology of symbionts are inadequately understood, especially when compared to what is known about free-living organisms. This lack of knowledge is particularly severe in the understanding of the role of hybridization and introgression, a process with a vital but still poorly understood role in the Ecology, Evolution, and Conservation Biology of many taxa. The overall aim of this proposal is to understand how hybridization operates in symbionts, a group of taxa exhibiting unique eco-evolutionary trajectories, and for which hybridization has almost never been studied. The research objectives are: 1) to investigate the pattern of introgression across the global tree of lice, 2) to research the role of introgression in shaping key eco-evolutionary variables related to dispersal and host-switching, and 3) to study the relationship between introgression levels and symbiont extinction rate. To complete the research objectives, I will be trained by the hosts and world-renowned experts in the analytical and theoretical aspects related to this highly integrative topic (e.g., Genomics, Bioinformatics, Coevolutionary Biology, and Biological Conservation). This training will increase my experience in different biological domains and will help me to develop my independent research group in the EU.

Keywords: coevolution,codiversification,dispersal,host symbiont systems,parasites
Cultural Loss Under Emulated Shocks – Demographic Environmental Climatic Empirical Bottlenecks (CLUES-DECEB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 255687.36
EU funding (EUR): 255687.36
Participants: 2
Project status: SIGNED

Cultural loss is a common phenomenon throughout human history, often in relation to major external shocks. Yet, there are few studies that analyse which process might govern it. CLUES-DECEB (Cultural Loss Under Emulated Shocks – Demographic Environmental Climatic Empirical Bottlenecks) homes in the resilience of culture under demographic and environmental shocks – prognosed to become more frequent and severe. By modelling and analysing drastic changes in population or in the environmental brought about by epidemics, climate change, mass-migrations, or natural hazards, CLUES pursues two key objectives: firstly, to model the cultural resilience after a given abrupt shock; secondly, to seek empirical testing of the models with archaeological case-studies. Adopting and adapting state-of-the-art analytical techniques that have been developed over the last two decades to study the relationship between demography, enviroment and cultural loss CLUES harnesses the computational power now available to run numerical models using the archaeological and cross-cultural databases such as Human Resources Area Files. CLUES is highly interdisciplinary, combining numerical and analytical modelling from a wide suite of fields, using tools developed to model cosmological datasets, data science, archaeological and anthropological data extraction and complex systems. This ambitious project will study culture aiming to forecast the requirements to achieve a general measure of the shock-induced tipping-points of culture. This is highly relevant at a global and European scale. At planetary scale, climate change and environmental degradation will bring to the tipping-point many vulnerable systems. In Europe, many rural areas and whole member states, are losing large amounts of population due to migration. Results will shed new light on our understanding of the past, and thanks to that help our present and have influence on the preservation of cultural diversity for the future generations.

Keywords: culture,cultural loss,resilience,intangible heritage,bottlenecks,tipping points,disasters,shocks,modeling,mock datasets,arcehologcal datasets,empirical,numerical,preservation,bayesian
Particle Reduced, Efficient Gasoline Engines (PaREGEn)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Germany,Germany,Germany,Germany,Spain,Italy,Germany,Germany,Switzerland,Belgium,Sweden,France,Czechia,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Technologies for low emission light duty powertrains (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2019-12-31
Duration (months): 39.0
Total project cost (EUR): 11973421.25
EU funding (EUR): 9952012.5
Participants: 22
Project status: CLOSED

PaREGEn addresses the short term scope of the GV-02 call via research into and the innovation of gasoline engines for light duty vehicles. Specifically, engines used in mid to premium passenger cars will be addressed. With the electrification smaller vehicles, focusing on larger cars is especially important: the need for clean, efficient & economic engines for inter-urban transport is more urgent and effective to resolve the challenges of air quality, decarbonisation & cost-effective mobility. Through using state of the art techniques, like optical engines, modelling & simulation tools (for new control strategies or understanding particle formation) and applying new engine componentry, the optimal trade-off between efficiency & emissions will be found. Of attention will be the control of particle numbers between 10 to 23nm. This learning will be used in two, manufacturer lead vehicle demonstrations. These demonstrators will use downsized engines not yet on the market. The two approaches will use different combustion, dilution, fuel injection, boosting and aftertreatment systems. Completion of the project will show the way forward to a 15% CO2 reduction along with real driving emissions limits. If adopted across all light vehicles these short term engine innovations will reduce the EU vehicle parc emissions by ~2MtCO2 in 2025, <10MtCO2 & ~10% PN>10nm in 2030. As well as improving EU competitiveness, a valuable contribution from PaREGEn will be new tools: to benefit engine design, development & control in general, long after project completion. PaREGEn has partners from EUCAR, CLEPA & EARPA; it is organized so learning from other projects in GV02 can be integrated. Experience from the PMP project and those proposed on particle measurement systems will be included via the partners & suppliers of PN-PEMS. PaREGEn’s partners give a global link to other nationally funded activities and, specifically, specialists in advisory roles will bring expertise from USA & Japan.

Keywords: lean,stochiometric