Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI-empowered Edge Cloud Continuum for self-aware cognitive computing environments (COGNIFOG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: France,Spain,Switzerland,Germany,Cyprus,Luxembourg,Greece
Call: Cognitive Cloud: AI-enabled computing continuum from Cloud to Edge (RIA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 5030875.0
EU funding (EUR): 5030875.0
Participants: 12
Project status: SIGNED

Next generation enablers, such as IoT, AI and cloud computing, open new opportunities to deal with world’s current and future societal, environmental, and economic challenges. However, they come with significant data management challenges. According to IDC, the total amount of data generated only by connected devices will exceed 40 trillion gigabytes by 2025. In most of the current systems, data storage and analysis happen on centralized locations on the cloud. This is pushing network capacity to its limits. Furthermore, centralized storage and processing lead to single point of failure situations, which are critically inefficient in case of disasters and crisis. Our world is continuously living natural disasters, health crisis, climate change and security threats that show the importance of resilient and energy-efficient information systems. COGNIFOG targets those challenges and proposes to build a Cognitive Fog Framework to: (i) reduce energy consumption and latency in next generation IT systems by reducing the network traffic, by analysing data at the edge in a distributed manner, closer to where they are generated, rather than routing them through the communication networks to a data center; (ii) reduce OPEX and faster service provisioning by providing a cognitive, self-adaptive framework with minimum or no human intervention, with dynamic provisioning of computing, storage and networking resources along the far-edge-to-edge-to-cloud path; (iii) ensure European leadership by providing an open interoperable framework with open APIs for application developers to rapidly create and deploy applications benefiting the edge-cloud continuum on top of heterogenous IoT/IT systems. COGNIFOG will validate project results in three representative application domains: critical collaboration missions, smart health and smart industry. With a consortium of 12 European partners, leaders in their domains, COGNIFOG will be a cornerstone in the cognitive fog computing domain

Keywords: artificial intelligence,intelligent systems,information security,cloud edge continuum,service orchestration
Energy production and storage using biological ion transport systems (Energion)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2858020.0
EU funding (EUR): 2858020.0
Participants: 1
Project status: SIGNED

This project aims to create a “green” energy storage system that integrates a biological voltage source with a biological supercapacitor to achieve large energy and power capacities in a light-weight sustainable packaging. The project re-defines the concept of “biological engineering” to be one that utilizes proteins, molecules and lipids in combination with synthetic materials to assemble the smart micro/nanostructured energy storage system. There are at least four advantages to this “biological engineering” approach, including (i) the capability for self-assembly, (ii) the easy scalability that follows from using self-assembly, (iii) the easy assembly into 3D structures, and (iv) up to 1000-fold less energy requirements for switching functions compared to state-of-the-art ENODe systems. Moreover, the use of biological components can overcome limitations of existing battery technology, by improving the ecological footprint and environmental sustainability, and by enhancing lifetime, reliability, and safety. The system will be assembled as an array of interconnected vesicles to form a compartmental system to control ion gradients established by co-transport proteins incorporated in the interconnecting vesicle membranes. The system utilises the ion gradient to sustain a stable voltage output, and as a supercapacitor to store energy. The stable voltage output and supercapacitor function are sustained from ion gradients and not catalytic electrochemical reactions. Since the system will function both as a generator and an energy accumulator, we anticipate power management would require an integrated design, rather than a discrete design used for traditional source/supercapacitor systems. The energy capabilities will be tested by packaging the system to provide power for an illustrative device that is either a typical nomadic device (e.g. smartphone), a typical implantable medical device (e.g. cardiac pacemaker), or a typical ambulatory device (e.g. drone).

Keywords: ion transport proteins,lipid bilayer membrane,nanobiotechnology systems
Investigating the impact of dysregulated inflammation in interferonopathy on hematopoiesis (Zeblood)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

Hematopoietic stem cells (HSCs), mostly quiescent cells in the bone marrow (BM), are essential throughout life because they are responsible for the continuous production of blood cells. They are of major clinical significance in the context of transplantation for hematological malignancy and the treatment of genetic hematological diseases. Despite major advances in our understanding of the biology of the blood system, understanding the progression of normal versus malignant hematopoiesis, clonal hematopoiesis (CH) or immune disorders is still challenging. My proposal is based on the finding that unbalanced tonic interferon signaling (TIS) emanating from the microbiome in vivo, accelerates the progression of myeloproliferative diseases induced by mutation of the hematopoietic tumor suppressor Tet2. Moreover, another component of TIS, called basal TIS is a fundamental mechanism underlying physiological HSC aging. In this proposal, I would like to explore the role of dysregulated inflammation, as in the case of interferonopathies, on hematopoiesis and hematopoietic stem and progenitor cell (HSPC) biology. I will use advanced molecular tools and technologies and a novel zebrafish model developed within this porposal. I hypothesize that understanding the interplay between chronic IFN activation on the HSCs and progeny over time could be crucial for developing effective treatments and improving outcomes for patients with these challenging disorders. This project will provide incisive insight into the biology of stem cells and into the role of inflammation on hematological malignancies.

Keywords: innate immunity and inflammation hematopoietic stem cell hematopoiesis type i interferon
Enslaved Persons in the Making of Societies and Cultures in Western Eurasia and Africa, 1000 BCE - 300 CE (SLaVEgents)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Greece,Italy,Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2495575.0
EU funding (EUR): 2495575.0
Participants: 3
Project status: SIGNED

SLaVEgents is an ambitious project focused on slave agency; it aims to explore how enslaved persons in antiquity actively shaped the societies they lived in. It will examine the multiple identities of enslaved persons, the communities and networks that they created or participated in, and how slave agency brought about major political, social, economic and cultural changes in the ancient world. By exploring the various forms of slave agency, SLaVEgents will offer a radically new perspective on antiquity from the point of view of history from below. The project moves beyond the usual focus on slavery in classical Greece and Roman Italy to offer a comprehensive examination of the history of enslaved persons across Western Eurasia and North Africa between 1000 BCE and 300 CE. SLaVEgents is the first project to examine together all ancient slaveries from Mesopotamia to the Atlantic, and include sources in the full range of ancient languages (Assyrian, Babylonian, Hebrew, Aramaic, Phoenician, Egyptian, Greek, Latin) and the relevant archaeological data. The research team – composed of the PI, eight senior researchers, seven post-doctoral researchers and three PhD candidates – will construct a large-scale digital prosopography of all attested ancient slaves which will include all relevant sources in the original and in English translation. The Linked Open Data created by the digital prosopography will enable new forms of quantitative and qualitative research and will make a significant contribution to Digital Humanities. The monograph and the two collective volumes of the project will offer an important step towards rewriting the history of antiquity with slaves at its centre. In addition, the project will deliver fifteen articles, three PhD dissertations, three workshops, one international conference and a website.

Keywords: slavery agency ancient history history from below mediterranean history ancient greece ancient rome history of the ancient near east ancient egypt ancient judaism
Fostering Sustainable, Balanced, Equitable, Place-based and Inclusive Development of Rural-Urban Communities' Using Specific Spatial Enhanced Attractivenes Mapping ToolBox (PoliRuralPlus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Innovation actions
Countries involved: Czechia,Ireland,Slovakia,Greece,Italy,Finland,Germany,Norway,Poland,Spain,Belgium,Latvia,Malta
Call: Improving rural future through better territorial governance and rural-urban synergies (HORIZON-CL6-2023-COMMUNITIES-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6201312.5
EU funding (EUR): 5498673.5
Participants: 20
Project status: SIGNED

The objective of PoliRuralPlus is to foster a sustainable, balanced, equitable, place-based and inclusive development of rural and urban areas through improved connections, governance arrangements, and integrated territorial policies that prioritise experimentation and innovation in domains that favour bi-directional urban-rural synergies and the development of a well-being economy. Key focus will be driven by Foresight, planning and implementation of integrated urban-rural strategies. The PoliRuralPlus project aims to improve the quality of life for people living in urban and rural areas across the EU by promoting coordinated and collaborative development within the regions. The project will support 9 pilot projects (including 8 from the previous PoliRural project and 1 new project) that focus on developing rural-urban partnerships. The aim is to increase the resilience and interconnectedness of urban and rural areas. In terms of financing, the project will demonstrate successful application of funding mechanisms to support these partnerships, including public-private partnerships, crowdfunding, and other innovative financing models. The goal is to find sustainable financing solutions that can support the long-term development of these partnerships. PoliRuralPlus will validate an EU-wide regional-driven integrated territorial planning & implementation Action-Foresight Process & Tool Box, by extending the latter’s Innovation Hub through the European Digital Innovation Hubs using open-source System Dynamic Modelling & a GIS collaborative online service called Map Whiteboard, enhanced by up-to-date Artificial Intelligence and Deep Learning (AI/DL) applicable algorithms. The project has an ambition to become an integral part of the New European Bauhaus due to its lighthouse success of gradual buildup of hands-on experience using up-to-date tools supporting decision-making process based on foresight principles.

Keywords: regional action plan,foresight,etools,rural urban synergies,new european bauhaus
The Digital Value Stream Twin for Lean and Green Manufacturing (LEAN-GREEN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

European manufacturers in a wide range of industries including automotive and electronics face three major challenges that threaten their competitiveness: compliance with stringent environmental directives, labour shortages, and underutilisation of vast production data. Traditional methods for identifying and addressing these problems, such as manual value stream mapping (VSM), are labour-intensive and prone to errors. These challenges hinder productivity, increase costs, and complicate efforts to meet environmental goals. ONIQ aims to address these challenges and revolutionise lean manufacturing with the IQA software. IQA generates a digital twin of production processes at the click of a button. The software uses data from existing IT systems to automatically reconstruct the actual process flows and material movements, eliminating the need for manual process mapping. This fully automates value stream mapping and enables data-driven process analysis. By streamlining data integration, analysis, and visualisation, IQA empowers manufacturers to achieve operational excellence, efficiency, and sustainability without extensive technical expertise or resources, making digital transformation to Industry 5.0 accessible and manageable even for companies with limited in-house IT capabilities. With automated lean manufacturing analysis, the industry-agnostic IQA software solution quickly uncovers improvement potential in production processess, offering manufacturing companies major value to reduce costs, save resources and improve effectiveness.

Keywords: lean manufacturing,digital value stream twin,digital twin for manufacturing,process mining for manufacturing
Automated Field eDNA Laboratory (AFDLAB) for unmanned biodiversity Surveillance (AFDLAB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1718500.0
EU funding (EUR): 1718500.0
Participants: 1
Project status: SIGNED

AFDLAB (Automated Field DNA Laboratory) aims to revolutionize biodiversity monitoring by providing a fully automated (off-grid and unmanned) solution for in-field eDNA sampling, handling, and analysis. This innovative technology will make automated biodiversity analysis accessible and affordable for both public and private organizations, enabling effective surveillance of invasive and rare species, and transforming how biodiversity is monitored on a global scale. This innovation not only enhances data quality but also enables real-time analysis, making it a game-changer in the field. The project is conducted by DMR A/S, a marked leading company combining environmental consultancy with hardware innovation and production. DMR has a clear vision for scaling up its operations. With a strong track record in developing innovative technologies, DMR aims to enhance its market position through the AFDLAB project, which aligns defined strategic growth goals. The project involves inherent risks associated with cutting-edge technology development. However, DMR's experience and the prototype's current TRL level 6 mitigate these risks. The company has demonstrated its ability to navigate challenges in previous projects, ensuring a robust approach to development. The proposal outlines a clear plan for transitioning AFDLAB from TRL 5, and DMR's established infrastructure and expertise in environmental technologies position it well for successful implementation. Funding from the EIC Accelerator is crucial for realizing the AFDLAB project. It will not only accelerate development but also attract further investment and interest from potential customers, including environmental agencies. This support aligns with EU priorities in sustainability and innovation, making it essential for the project's success.

Keywords: edna,biodiversity surveillance,robotics,aquatic ecosystems,invasive species,remote sampling,environmental protection,automation,data analysis,ecological research,modular design
Development and manufacturing of forest-based membranes for electrochemical energy devices (CNF Membrane)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Challenge: Energy storage (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 3478832.5
EU funding (EUR): 2435182.0
Participants: 1
Project status: SIGNED

Emerging technologies such as Proton Exchange Fuel Cells (PEMFCs) and Redox Flow Batteries (RFB) are expected to contribute to society’s transition towards renewable energy. However, these technologies use toxic, PFSA-based membranes which have caused serious ill effects on human health and the environment. In fact, the overall health cost due to PFAS usage is estimated to be between €52 and €84 billion per year, as a result of this the EU is placing restrictions to ban the substances, which initial bans already commencing. This has resulted in major companies such as 3M announcing to stop all production of PFAS-based materials by 2025, a decision worth 2 billion USD annually. To overcome this, Cellfion has developed a bio-based, ion-selective membrane derived from natural cellulose, the first of its kind. This innovation is 27 times more cost-effective compared to the competing solution while providing the potential for increased performance

Keywords: membrane technology,ion transportation,proton transport ion filtration,porous materials,dispersions,proton exchange membrane,fuel cells,redox flow batteries,cellulose,nano particles,hydrogen
DEVELOPMENT OF A HIGH THROUGHPUT SCREENING PLATFORM TO ACCELERATE DRUG DISCOVERY FOR AGE-RELATED DISEASES (HTS Drug Discovery)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 12.0
Total project cost (EUR): 237837.0
EU funding (EUR): 237837.0
Participants: 1
Project status: SIGNED

Accelerating drug discovery timelines is crucial for delivering faster patient treatments and reducing costs in the pharmaceutical industry. Traditional High Throughput Screening (HTS) methods primarily focus on cellular or molecular readouts; however, leveraging C. elegans for whole organism readouts at HTS levels presents a transformative opportunity. A significant challenge for pharmaceutical clients is obtaining early functional readouts from large compound libraries, which is essential for effective drug development. Magnitude Biosciences has developed an innovative and scalable platform using our patented WormGazer™ technology to automate drug testing with C. elegans. This approach enables in vivo testing much earlier in the research process, enhancing efficacy and safety assessments. By monitoring and analyzing the movement of C. elegans, our technology generates detailed and quantitative health data, providing multiple endpoints that traditional methods fail to capture. The use of C. elegans significantly reduces reliance on mammalian models, aligning with ethical standards while minimizing environmental impact through decreased resource use and waste. Our platform allows for comprehensive insights into healthspan data beyond mere lifespan metrics, addressing the urgent need for drug discovery in treating chronic age-related diseases, such as Alzheimer’s and Parkinson’s. With a globally aging population, the demand for effective interventions is growing. By increasing the number of compounds screened, our technology enhances the likelihood of discovering effective treatments that can slow aging or prevent age-related diseases. The ability to perform high-throughput, whole organism screening with C. elegans not only streamlines the drug discovery process but also has the potential to revolutionize early-stage drug development. In summary, this project aims to establish Magnitude Biosciences at the forefront of drug discovery, significantly impacting neuro

Keywords: drug discovery,high throughput screening,c elegans