Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multimodal Data Integration in Personalized Cardiovascular Medicine (Nextgen HOP-on) (Nextgen Hopon)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 34.0
Total project cost (EUR): 267847.5
EU funding (EUR): 267847.5
Participants: 2
Project status: CLOSED

Cardiovascular diseases are the most common cause of death in EU member countries1. To reduce their burden and improve quality of life, it is critical for healthcare procedures to become more personalized. This requires the integration of information from multiple types of medical data (clinical, imaging, functional, molecular, genomic) and from multiple centers. However, integrating multimodal data raises problems regarding the dimensions and characteristics of the various modalities, as well as situations where one or more of the modalities can be unavailable across sites. This proposal aims to overcome the challenges brought by combining multiple modalities in missing settings, through the development of robust single modality encoding strategies as well as a novel universal multimodality integrator that uses transformers to handle the missing information. Towards these goals we propose to integrate the NextGen consortium, who is already working towards the integration of multiple modalities, bringing new capacity to the NextGen consortium and contributing to improving its tools.

Keywords: mulltimodal data,ai,cardiovascular diseases,missing data
Fast-MAS Solid-State NMR as a Bypass to High-Molecular-Weight Proteins in Solution (bypassNMR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1999833.0
EU funding (EUR): 1999833.0
Participants: 1
Project status: SIGNED

My objective is to establish methodology expanding the detailed characterization and exploitation of backbone dynamics in complex proteins up to 80-100 kDa monomer molecular weight. Experimental elucidation of protein motion is imperative for fundamental understanding of enzymatic and regulatory features. However, with a limit of regularly around 40-50 kDa maximum total mass, the more complex targets of current scientific interest usually evade solution NMR backbone resonance assignment and remain inaccessible for the majority of sophisticated methods for protein dynamics. This paradigmatic shortcoming has led to serious limitations in the understanding and exploitation of protein dynamics. Here I aim to achieve a two-fold expansion of the accessible molecular-weight range by an unprecedented hybrid strategy. Based on the unmatched prospects of 4D and 5D solid-state NMR (ssNMR) assignment data for a 2x72 kDa protein, I will establish proton-detected, higher-dimensionality ssNMR methodology as a powerful framework for NMR assignment in an unprecedented size range. Subsequently, developing strategies utilizing ssNMR assignments as a springboard to solution NMR will enable detailed characterization of those targets under close-to-physiological conditions. This fundamentally new BYPASS strategy will allow understanding of intramolecular regulatory circuits and coupled motional networks in innumerable, previously inaccessible complex proteins, with a transformative impact for dynamics, in particular allosteric regulation, in structural biology. Fueled by my role as a key player in revolutionizing solid-state NMR via proton-detected, fast magic-angle spinning NMR methodology, my achievements will be paradigmatic for the accessibility and utility of dynamics for the structure-dynamics-function relationship of proteins and will have widespread consequences for a wide range of structural biology and downstream applications such as pharmacology and biotechnology.

Keywords: solid state nmr spectroscopy,protein nmr,methods development
Comprehensive multiscale modelling of atomistic and electronic structure of radiation-induced defects in semiconductors (MUST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1499978.0
EU funding (EUR): 1499978.0
Participants: 1
Project status: SIGNED

Despite more than a century of interest in the effects of energetic particles in matter, quantitative predictions of the radiation damage remain elusive in many cases. The goal of this project is to transform the study of radiation-induced damage in semiconductors from an empirical approach to one of fundamental physics, to obtain reliable predictions of radiation damage crucial for practical applications. Particle irradiation effects are of great importance, since they can modify the physical and mechanical properties of materials, the outcome of which is often detrimental to the materials employed in high radiation environments. Conversely, ion irradiation also has the potential to improve material performance, and ion beam modification of materials is used widely in semiconductor technology. In this project, I will elucidate the fundamental quantum effects under irradiation in semiconductors, and their impact on the atomic dynamics, through a multi-scale modelling scheme employing a combination of ab initio calculations and large scale atomistic simulations. The high gain from the project will be quantitative high-fidelity predictions of radiation effects in semiconductors, to enable the optimal design of components for power devices, and the development of next generation electronics for demanding environments. I will develop a genuinely predictive modelling scheme, using a combination of state-of-the-art first principles calculations, machine learning methods for modelling atomic interactions, and molecular dynamics simulations in multi-million atom systems, together with electron microscopy simulations and ion range calculations to obtain quantitative predictions of experimentally measurable radiation effects for different irradiating particles and energies. This methodology will form a truly bottom-up approach to the study of radiation damage in technologically relevant semiconductor materials.

Keywords: radiation damage,defects,molecular dynamics,density functional theory
Center for Glacial Biome Doctoral Network (ICEBIO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Austria,Germany,Norway,United Kingdom,Switzerland,France
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2975858.66
EU funding (EUR): 2820448.8
Participants: 16
Project status: SIGNED

Glaciers and ice sheets were long believed to be sterile environments, but just like other large ecosystems (e.g., tropical forests, tundra), they are now widely recognized as one of the Earth’s biomes, teeming with life. Active algae, fungi, bacteria and viruses dominate the glacial environment and they have the ability to change the physical and chemical characteristics of the ice and snow, with global effects. For instance, increasing ice melt rates are observed due to growth of pigmented algae on glacier surfaces and substantial amounts of methane from subglacial habitats are added to the global greenhouse gas budget. Despite their global influence, many of the microbiological processes within the cryosphere remain poorly quantified. A deeper understanding of such processes are relevant to researchers interested in the possibility of life on icy extraterrestrial bodies, the survival and proliferation of life forms on our early Earth (e.g. during the part of the Proterozoic era known as Snowball Earth), and the positive and negative feedbacks that the cryosphere may have on global warming. The microbial communities living in association with icy environments may also harbor unique metabolic pathways, providing novel opportunities in biotechnology. ICEBIO is a Doctoral Network that will train the next generation of glacier microbiology and biogeochemistry experts. The training and research programme is made up of seven interlinked Work Packages (WP). WP1 to WP4 are research work packages at the cutting edge of glacial microbiology and biogeochemistry and these will be supported by three overarching WPs (WP5-7) associated with the management, training, and dissemination of results. ICEBIO will deliver a detailed framework and database of the functional diversity and potential of the glacier biome, not only serving to dramatically advance our understanding of a threatened biome, but also laying out potential for use in economic and environmental services.

Keywords: microbial ecology,environmental microbiology
Enhancing Capacities for Quality and Impactful Research on Transformations, Labour and Migration in Southeast-Europe (RETLAMI-SEE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Bosnia and Herzegovina,Austria,Slovenia,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1386349.06
EU funding (EUR): 1386349.06
Participants: 4
Project status: SIGNED

RETLAMI-SEE is dedicated to enhancing capacities of the University of Banja Luka (UNIBL) and its researchers for conducting a quality and impactful, interdisciplinary research on transformations, labour and migration in Southeast Europe (SEE). RETLAMI-SEE aims at building up capacities of early stage researchers and recent PhD graduates from the UNIBL to pursue high quality interdisciplinary research on policy-relevant topics. The concept is based on networking, peer-learning and mentoring schemes that allow for knowledge exchange between the UNIBL researchers and more experienced researchers as well as peers from the three well established European research institutions (UNIVIE, ZRC SAZU and IOS) all with documented experience in interdisciplinary research on the issues of transformations, labour and migration in SEE. RETLAMI-SEE will pursue a strategic and targeted approach by employing the following measures: 1) Development of the detailed strategy and action plan for enhancing the research and research management and administration staff (RMA) profiles of the UNIBL staff; 2) Establishment of the Research Group on Transformations, Labour and Migration in SEE at UNIBL that will build on the activities and results of the project and ensure the sustainability and exploitation of the RETLAMI-SEE results. It will also function as a platform for future international collaboration; 3) Series of peer learning and knowledge sharing events both between the researchers, and between the RMA staff of participating institutions; 4) Networking through both participation at international conferences and joint organisation of the conferences and panels with the partners thus increasing the visibility of UNIBL researchers in the wider European and international academic community; 5) Conducting an exploratory research in collaboration with the European partners will enable ESR and post-docs from UNIBL to enhance their research skills.

Keywords: transformations,labour,migration,southeast europe
Commercialisation of the first fully integrated continuous metal powder gas atomising plant with reduced inert gas and energy consumption to reduce specific powder manufacturing costs by over 50 %. (Gen6 Gas Atomiser)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 1314476.0
EU funding (EUR): 1314476.0
Participants: 1
Project status: SIGNED

Gen6 Gas Atomiser is a state-of-the-art metal powder processing plant specialising in manufacturing stainless steel powders. It is designed to be a fully integrated powder production plant utilising continuous melting, atomising, powder classifying and sieving processes, making it the first of its kind in the world. The plant reduces energy consumption significantly compared to traditional total gas loss atomisers by recycling the atomising gas and utilising waste heat from the compression stage of the gas recycling circuit. Additionally, the plant minimises the need for manual labour, thus reducing labour costs. Going from a typical batch based gas atomising plant to a continuous process the Gen6 technology will achieve a 200-300% increase in output per atomising line.

Keywords: gas atomiser,metal powder,stainless steel powder,powder production
THUMBS-UP: TidalKite Harvesting Unit Made Better for Scalable Utility Power generation (THUMBS-UP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The THUMBS-UP project focuses on realising a pre-commercial demonstration TidalKite system. The TidalKite is an innovative 2nd generation tidal energy solution based on an underwater kite. A kite can sweep a much larger area, certainly in shallow water flows, enabling access to much more energy and thus a higher energy yield (3 times as much) per device. The benefits of the recyclable TidalKite system include lower investment and operational costs, a wider deployment potential and a better spatial and ecological tie-in. Tidal energy is predictable and available every day of the year. Providing continuous renewable energy 24/7/365 based on TidalKite energy is more cost efficient compared to alternatives as requiring much less storage capacity in comparison to a system powered by intermittent and varying solar and wind sources. Tidal energy complements the renewable energy mix and increases the security of energy supply. The TidalKite system doubles the tidal energy market potential in Europe and beyond. It makes new locations available to accelerate the energy transition with more renewable energy production, complementing existing renewables. Also, it enhance the EU energy autonomy based on a EU supply chain and as such contributes to the work programme challenge 2.6. SeaQurrent has a long and successful track record and a dedicated, experienced and committed team. We have realised 4 kites, 2 power take-off (PTO) units, a hydraulic energy converter that produces renewable electricity from the kite's traction forces and a grid connected test site near Ameland (NL). This year we plan to finalise TRL6 with kite number 4. In parallel we plan to start with the TRL7 phase, in which we will design, construct and test the THUMBS-UP TidalKite system, as our final demonstrator before market introduction. This value inflection point bridges the gap to engage interested private investors and customers for a successful market introduction of the TidalKite system.

Keywords: energy,renewable energy,sustainable energy,tidal energy,kiting,ocean energy,reliable renewable energy,baseload power
SOMEBUDDY: Human-in-loop AI Revolutionising Online Safety for European Youth (SOMEBUDDY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

SomeBuddy is pioneering a paradigm shift in online safety, harnessing cutting-edge AI to empower professionals and protect millions of European children from the devastating impacts of cyberbullying and online crime. Our proven human-in-loop AI technology, validated through successful implementation in Finland, is poised to transform the way we address online harassment, providing scalable, accessible, and effective support to schools and communities across the EU. In today’s interconnected world, where platforms like TikTok and Snapchat, influence our social dynamics, ensuring online safety is a crucial issue that impacts society, wellbeing, security and democracy at large. By integrating AI with legal and psychological expertise, we have created a unique solution that not only empowers victims but also equips schools with the tools and insights needed to foster a safe and supportive digital environment. With SomeBuddy’s human-in-loop AI solution, professional aid can be scaled to protect communities of all sizes and provide help for a large group of victims with only little human resources. With a rapidly growing market and 80 million children and adolescents in the EU alone, the potential for impact is immense. Opening the bottle-neck of the B2G market requires strategic investment to unlock the full potential of our groundbreaking technology. Investing in SomeBuddy means investing in the future of online safety, the well-being of children, and the growth of a socially responsible, high-impact business with global potential. Join us in our mission to revolutionize online safety and create a safer digital world for future generations.

Keywords: online safety,cyberbullying,artificial intelligence,social innovation
Democratizing Cryogenic Measurements for the Quantum Ecosystem (CRYOFAST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In the rapidly evolving landscape of quantum technology, Europe faces a critical gap in access to professional testing & characterization services. With a growing number of players entering the quantum ecosystem, the need for a centralized, advanced, & accessible facility to perform cryogenic measurements on sensitive devices is more pronounced than ever. kiutra has a breakthrough solution to this challenge: a state-of-the-art low-temperature characterization service leveraging our cutting-edge cryostat hardware. This places us in pole position to offer rapid, precise testing for an affordable fee, ‘Cryogenics-as-a-Service’, reducing test result times from weeks-months to days and lowering the bar to startups, SMEs, & researchers without capital/expertise to acquire/manage specialized low-temperature hardware. With our solution poised to transform markets, kiutra presents a timely opportunity for EIC support, propelling our innovative European company to global quantum industry leadership.

Keywords: cryogenics low temperature cooling system quantum technology quantum computing quantum devices
Industrialization and scale-up of a novel process for critical metals recovery from industrial wastewater (CMHubs)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1.0
EU funding (EUR): 1.0
Participants: 1
Project status: SIGNED

Industrial Wastewater Treatment Plants (IWWTP) discharge 3,000 tpa of heavy metals into the environment due to the limitations of chemical-physical precipitation processes. The SotA technology generates 4 Mtpa of sludges containing up to 60,000 tps of heavy metals. Only 5% of these sludges are recycled due to a lack of technological solutions, while 95% are sent to landfills as special waste. Consequently, up to 30,000 tpa of metals such as Nickel, Copper, and other critical and strategic raw materials are lost from the value chain. Circular Materials has developed and patented a unique technology that can simultaneously treat industrial wastewater and recover over 99.9% of dissolved metals, even from chemically complex waste matrices. The recovered Secondary Raw Materials (SRM) are of high purity and have a low carbon footprint, meeting the increasing EU demand. Following our successful EIC Accelerator Phase II project, where we validated our patented supercritical water precipitation (SWP) process for removing and recovering dissolved metals and SRM in an industrial environment, Circular Materials is now reaching a new milestone. In a strategic decision to adapt to market needs, the company will operate through “Circular Materials Hubs” (CMH), located in key industrial districts across Europe. We have received authorization to operate the first centralized critical raw materials recovery centre in Italy: our “CMH Zero.” The successful implementation of this operations model, supported by EICA equity, will enable its replication in key industrial districts across Italy and Europe. This will significantly impact the sustainability of several industrial sectors by treating and valorizing wastewaters.

Keywords: secondary raw materials,critical raw materials,heavy metals,supercritical water precipitation,metal recovery