Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Surface Enhanced Raman Spectroscopy (SERS) based technologies for gas and liquids sensING in the area of chemical protection (SERSing)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Sweden,Sweden,Czechia,Netherlands,Denmark,Denmark
Call: Chemical, biological, radiological and nuclear (CBRN) cluster (H2020-SU-SEC-2019, 2019)
Start date: 2020-07-01
End date: 2024-06-30
Duration (months): 48.0
Total project cost (EUR): 4741918.75
EU funding (EUR): 4741918.75
Participants: 8
Project status: SIGNED

The ultimate goal of SERSing is to enable fast detection and unequivocal identification of chemical hazards at low concentrations in gas and liquid phase, in multiple environments. The geo-located acquired data are submitted to an on-line learning platform and processed, transmitting threats and hazard data to authorized personnel and generating alerts on the incident scene in real time. The innovative microdevices for detection and identification are integrated in low weight hand-held Raman equipment, specifically customized to overcome the common operational limitations of first responders, compatible with Personnel Protective Equipment PPE and respirators, easy to use and maintain with low cost of consumables. The robust, reliable, ultrasensitive lab on chips (LoCs) for on-site detection of chemical threats in gas and liquids are based on Surface Enhanced Raman Spectroscopy (SERS). The customized Raman spectrometer will combine geo-location and communication technologies specifically adapted for the rapid screening of the incident scene. This miniaturized platform could be also mounted on robotic units to inform operational command on possible chemical agents in preparation of entering the incident scene where the deployment of personnel is difficult. These SERS LoCs and the adapted Raman are also envisioned as complimentary forensics tools and technologies that can be used: i) “on scene” to determine the chemical nature of a sample in order to collect it for further laboratory analysis or dismiss it; or ii) “in a laboratory environment” for profiling chemical agents released at an incident and to identify signatures for improved attribution.

Keywords: surface enhanced raman spectroscopy,chemical threats,first responders
DownScaling CLImate imPACTs and decarbonisation pathways in EU islands, and enhancing socioeconomic and non-market evaluation of Climate Change for Europe, for 2050 and beyond. (SOCLIMPACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Spain,Italy,Italy,Italy,Italy,Italy,Germany,Cyprus,Malta,Greece,Greece,France,France,France,United Kingdom,Portugal,Portugal
Call: Pathways towards the decarbonisation and resilience of the European economy in the timeframe 2030-2050 and beyond (H2020-SC5-2017-OneStageB, 2017)
Start date: 2017-12-01
End date: 2021-03-31
Duration (months): 40.0
Total project cost (EUR): 4481340.0
EU funding (EUR): 4481340.0
Participants: 28
Project status: CLOSED

The warming of the climate system is unequivocal and continued emission of greenhouse gases will cause further warming and changes. Islands are particularly vulnerable to Climate Change (CC) consequences but the coarse spatial resolution of available projections makes it difficult to derive valid statements for islands. Moreover, science-based information about the economic impacts of CC in marine and maritime sectors is scarce, and current economic models lack of solid non-market assesment. Policy makers must have accurate information about likely impact chains and about the costs and benefits of possible strategies to implement efficient measures. SOCLIMPACT aims at modelling downscaled CC effects and their socioeconomic impacts in European islands for 2030–2100, in the context of the EU Blue Economy sectors, and assess corresponding decarbonisation and adaptation pathways, complementing current available projections for Europe, and nourishing actual economic models with non-market assessment, by: • Developing a thorough understanding on how CC will impact the EU islands located in different regions of the world. • Contributing to the improvement of the economic valuation of climate impacts by adopting revealed and stated preference methods. • Increasing the effectiveness of the economic modelling of climate impact chains, through the implementation of an integrated methodological framework (GINFORS, GEM-E3 and non-market indicators). • Facilitating climate-related policy decision making for Blue Growth, by ranking and mapping the more appropriate mitigation and adaptation strategies. • Delivering accurate information to policy makers, practitioners and other relevant stakeholders. SOCLIMPACT addresses completely this Work Programme providing advances in the economic valuation of climate-induced impacts, and in climate and economic models, allowing downscaled projections of complex impact chains, and facilitating the resilience capacity of these vulnerable lands.

Keywords: economic impact of climate change,non market impact of climate change,outermost regions and islands,blue growth
MAnufacturing process for Cold-chain Independent VIrosome-based VAccines (MACIVIVA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Developing next generation nanomaterials, nanodevices and nanosystems
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Switzerland,Netherlands,United Kingdom,United Kingdom
Call: Scale-up of nanopharmaceuticals production (H2020-NMP-PILOTS-2014, 2014)
Start date: 2015-05-04
End date: 2018-11-03
Duration (months): 42.0
Total project cost (EUR): 8438905.63
EU funding (EUR): 5338886.88
Participants: 6
Project status: CLOSED

MACIVIVA is a highly interdisciplinary consortium among well established and innovative SMEs with scientific excellence and complementary industrial world-leading experts with unique expertise and know-how in virosome technology, spray and freeze drying, large scale manufacturing and packaging. MACIVIVA will pave the path to other large scale thermostable nanopharmaceuticals products for therapeutic and prophylactic vaccines and other potential applications for direct application by non-invasive routes. Liquid products are inherently prone to physical and/or chemical modifications and degradations. Solid vaccine dosage formats (e.g. powder) may prevent molecular motion and shear-induced degradation, and slow down degradation involving water and oxygen radicals, resulting in improved stability and enhanced shelf-life of vaccines. The cold chain storage is still fundamental for preserving the bioactivity of most liquid and freeze-dried vaccines, and a reconstitution step prior to administration is required for freeze dried vaccines that are usually administered intramuscularly or subcutaneously. These reconstituted freeze dried vaccines harbor important instability and must be used within hours and kept refrigerated. Because most liquid and reconstituted freeze-dried vaccines are susceptible to degradations, it may affect the immunological properties of the immunogens, with unwanted immune responses or insufficient immune protection. For addressing liquid virosome-based vaccine instability and improving their shelf-life outside the cold chain, MACIVIVA will explore new galenic vaccine formulations through careful screening of excipients, stabilization and drying methods for generating new vaccine solid forms that can be easily self-administered. Robust “universal” manufacturing processes for upscale production of virosome dried powder for the non-invasive intranasal, oral and sublingual routes should be achieved by month 42.

Keywords: nanovaccine,virosome,spray drying,cold chain independent vaccine,thermostable powder vaccine,dry powder vaccine,non invasive route,sublingual delivery,nasal delivery,oral delivery
Exploration of safety, tolerability and clinical efficacy of Solnatide IMP in patients infected with the 2019 new coronavirus (Solnatide)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Austria,Spain
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2022-06-30
Duration (months): 27.0
Total project cost (EUR): 1626025.0
EU funding (EUR): 1626025.0
Participants: 6
Project status: CLOSED

Clinical features of patients infected with the 2019-nCoV have revealed that these patients suffer from severe respiratory failure, and presence of a life-threatening pulmonary oedema (PPO). Approx. 30% of 2019-nCoV-patients further develop life-threatening Acute Respiratory Distress Syndrome (ARDS). Mortality rate of these patients is very high. Initiator and Scientific Coordinator of the project, APEPTICO, is a SME biotechnology company (EMEA/SME/012/09) developing peptide-based products targeting life-threatening pulmonary diseases, including oedematous respiratory failure, acute lung injury, primary graft dysfunction, high altitude pulmonary oedema and PHA type 1. APEPTICO’s lead-compound Solnatide (INN) has been designed for the therapeutic treatment of patients with Acute Respiratory Distress Syndrome (ARDS) and various forms of life-threatening Pulmonary Oedema (PPO). Orally inhaled Solnatide has delivered clinical proof-of-concept in one Phase I, and in two Phase II clinical studies (EUDRACT No. 2011-000223-33, 2012-001863-64, 2013-000716-21). Today, no medicine has been approved for the therapeutic treatment of Pulmonary Permeability Oedema and ARDS. Currently, Solnatide is subject to a Phase IIB trial (EUDRACT No. 2017-003855-47) for the “treatment of pulmonary permeability oedema in patients with ARDS”. The Phase IIB clinical trial has been approved by the German and the Austrian Competent Authorities, as well by Ethic Committees of leading Medical University Hospitals in Germany as well Austria. Most recently, APEPTICO has entered into a partnership with HAISCO Pharmaceutical Group in Chengdu, Sichuan, P.R. China. HAISCO has access to core areas and leading Medical University Hospitals in the P.R. China. Accordingly, APEPTICO proposes to immediately apply the Solnatide IMP for the treatment of patients infected with the 2019-nCoV and to demonstrate safety, tolerability and clinical efficacy of Solnatide IMP in 2019-nCoV patients. The overall project coordination and external communications is by RTDS Association (www.rtds-group.com/association)

Keywords: solnatides,ards,acute respiratory distress syndrome,therapeutic peptide,patient treatment,pulmonary oedema,clinical study
Innovative Prima system to clean and Polish Bottles (PPB)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Italy
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 792750.0
EU funding (EUR): 554925.0
Participants: 1
Project status: CLOSED

Sparkling wine produced by the Champenoise method implies the use of long periods of storage of bottles. The bottles, due to long-time storage, are prone to defacements like iridescence, lime scales, or rust. These bottle defects do not affect the valuable content, but as a luxury product, the bottle needs to be pristine in its presentation. Today this tedious bottle cleaning and polishing work are done by hand, and when cannot be manually polished, this one becomes waste, out of the quantity of water and time consumed. Moët Chandon approached us to develop machinery to develop such work to avoid such work. PRIMA develops new machinery in the market for the successful polishing of such a bottle in dry and/or wet methods with the use of little water. With this machinery (PPB), we see a clear competitive benefit for the client company as it we calculate it has the potential to generate 2.1M€ savings on the average large producer (500,000b/y) and 1.05M€ for medium-small producers. PPB is a logical evolution for PRIMA - a manufacturing group in the fields of automotive, lighting, and labeling - to open a new business category and a new market positioning. Our expertise in manufacturing labeling machinery for bottles (www.primalabelling.it) will be used for a successful PPB manufacturing. Thus, we expect that PRIMA will lead to a new production line with a strong business capacity of 11M€ accumulated profit in 5 years of exploitation and the creation of 14 new working positions.

Keywords: machinery,wineries,champenoise,bottles treatment,champagne bottles,sparkling wine,industry automation,cleaning,polishing
Earth’s first biological bloom: An integrated field, geochemical, and geobiological examination of the origins of photosynthesis and carbonate production 3 billion years ago (EARTHBLOOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,Canada
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1848685.0
EU funding (EUR): 1717435.0
Participants: 2
Project status: CLOSED

The origin of oxygenic photosynthesis is one of the most dramatic evolutionary events that the Earth has ever experienced. At some point in Earth’s first two billion years, primitive bacteria acquired the ability to harness sunlight, oxidize water, release O2, and transform CO2 to organic carbon, and all with unprecedented efficiency. Today, oxygenic photosynthesis accounts for nearly all of the biomass on the planet, and exerts significant control over the carbon cycle. Since 2 billion years ago (Ga), it has regulated the climate of our planet, ensuring liquid water at the surface and enough oxygen to support complex life. The biological and geological consequences of oxygenic photosynthesis are so great that they effectively underpin what we think of as a habitable planet. Understanding the origins of photosynthesis is a paramount scientific challenge at the heart of some of humanity’s greatest questions: how did life evolve? how did Earth become a habitable planet? EARTHBLOOM addresses these questions head-on through the first comprehensive scientific study of Earth’s first blooming photosynthetic ecosystem, preserved as Earth’s oldest carbonate platform. This relatively unknown, >450m thick deposit, comprised largely of 2.9 Ga fossil photosynthetic structures (stromatolites), is one of the most important early Earth fossil localities ever identified, and EARTHBLOOM is carefully positioned for major discovery. EARTHBLOOM will push the frontier of field data collection and sample screening using new XRF methods for carbonate analysis. EARTHBLOOM will also push the analytical frontier in the lab by applying the most sensitive metal stable isotope tracers for O2 at ultra-low levels (Mo, U, and Ce) coupled with novel isotopic “age of oxidation” constraints. By providing new constraints on atmospheric CO2, ocean pH, oxygen production, and nutrient availability, EARTHBLOOM is poised to redefine Earth’s surface environment at the dawn of photosynthetic life.

Keywords: geobiology,paleoredox,metal isotopes
Understanding the Complexity of Modern Financial Systems (COMPLEXITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1498947.0
EU funding (EUR): 1498947.0
Participants: 1
Project status: CLOSED

The modern financial system has undergone immense transformation in recent years and is far more complex than ever before. In lockstep, financial regulation has also become more complex. This research proposal attempts to improve our understanding of potential drivers of this complexity and the implications of this change on the allocation of resources. Taking a positive rather than a normative approach, I will analyse post-crisis changes at both the micro- and at the macro-levels to create a broader understanding of complexities in the current financial system. In order to do so, I will employ a set of advanced research designs, as well as a uniquely assembled micro-level dataset covering state and privately owned financial institutions in Asia, Africa, South America and Europe. This project will focus on two interconnected areas of research: 1) Organisation of Credit, 2) Financial regulation in a complex environment. The aim of this project is to create a sustainable framework for the study of post-crisis financial systems, and to shape the current debate on the future of post-crisis financial structures and the development of policy in this area. Not only will this research have a considerable impact on our understanding of financial systems, it will also impact fields beyond finance, like Organisational Economics, Industrial Organisation and Development Economics.
Adaptive Multimodal Interfaces to Assist Disabled People in Daily Activities (AIDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Spain,Germany,Spain,Spain,United Kingdom
Call: Multimodal and Natural computer interaction (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-05-31
Duration (months): 40.0
Total project cost (EUR): 3409431.25
EU funding (EUR): 3409430.75
Participants: 10
Project status: CLOSED

Around 80 million people in the EU, a sixth of its population, have a disability. Beside this, accessibility is a basic right for all persons with disabilities according to the article 9 of the United Nations Convention on the Rights of Persons with Disabilities signed by the European Commission in 2010. The purpose of accessibility is to enable persons with disabilities to live independently and to participate in all aspects of life. The AIDE project has the ambition to develop and pre-clinical validate a novel and revolutionary modular and adaptive multimodal human-machine interface to allow that moderately and severely impaired people interact with intelligent devices to perform daily activities and to fully participate in society. It will, furthermore, focus on the development of a totally new shared-control paradigm for assistive devices that integrates information from identification of residual abilities, behaviours, emotional state and intentions of the user on one hand and analysis of the environment and context factors on the other hand. A series of applications for the AIDE system have been identified across several domains in which disabled people could greatly benefit: communication, home automation, wearable robots for assisting in activities of daily living and entertainment. The validation of AIDE system will be deployed during 8 months to 5-10 users in the UK at Cedar Foundation. The final goal of this process will be to provide the “proof of concept” of the advantages of the AIDE system based on a novel modular, natural and adaptive multimodal interface and a shared control system to assist disabled people in accordance with specific user needs.

Keywords: upper limb robotic exoskeleton,multimodal interfaces,shared control
Participatory Urban Living for Sustainable Environments (PULSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Italy,Spain,Taiwan, Province of China,Serbia,France,France,United States,United Kingdom,United Kingdom,United Kingdom
Call: Big Data supporting Public Health policies (H2020-SC1-2016-CNECT, 2016)
Start date: 2016-11-01
End date: 2020-04-30
Duration (months): 42.0
Total project cost (EUR): 5081649.0
EU funding (EUR): 4995515.0
Participants: 14
Project status: CLOSED

PULSE (Participatory Urban Living for Sustainable Environments) will leverage diverse data sources and big data analytics to transform public health from a reactive to a predictive system, and from a system focused on surveillance to an inclusive and collaborative system supporting health equity. Working within five global cities, PULSE will harvest open city data, and data from health systems, urban and remote sensors, personal devices and social media to enable evidence-driven and timely management of public health events and processes. The clinical focus of the project will be respiratory diseases (asthma) and metabolic diseases (Type 2 Diabetes) in adult populations. The project will develop risk stratification models based on modifiable and non-modifiable risk factors in each urban location, taking account of biological, behavioural, social and environmental risk factors. Following the recommendations of WHO Europe (2015), the project will also focus on the development of metrics, and data-driven approaches, to community resilience and well-being in cities. Deploying a Health in All Policies (HiAP) perspective, and a ‘whole-of-city’ model, the project will integrate and analyze data from the health, environment, planning and transport sectors in each city. PULSE will pioneer the development and testing of dynamic spatio-temporal health impact assessments using geolocated population-based data. PULSE will also develop simulation models of potential policy scenarios to allow decision-makers, citizens and businesses to ascertain the impact of proposed policies. The project will culminate in the establishment of Public Health Observatories in each urban location. These observatories will serve as linked hubs that utilize knowledge-driven processes and big data to shape intersectoral public policy and service provision, support citizen health, and encourage entrepreneurship in the fields of data science and mobile health.

Keywords: predictive models,big data analytics,t2d and asthma