Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flexible and efficient hardware/software platforms for 5G network elements and devices (Flex5Gware)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Germany,Italy,Spain,Spain,Germany,Belgium,Sweden,Sweden,Finland,Greece,France,France,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 7993586.25
EU funding (EUR): 7993585.25
Participants: 21
Project status: CLOSED

The overall objective of Flex5Gware is to deliver highly reconfigurable hardware (HW) platforms together with HW-agnostic software (SW) platforms targeting both network elements and devices and taking into account increased capacity, reduced energy footprint, as well as scalability and modularity, to enable a smooth transition from 4G mobile wireless systems to 5G. As it will be argued in the proposal, this approach will be necessary so that 5G HW/SW platforms can meet the requirements imposed by the anticipated exponential growth in mobile data traffic (1000 fold increase) together with the large diversity of applications (from low bit-rate/power power for M2M to interactive and high resolution applications). Flex5Gware will adopt a holistic approach performing research and implementations on key building blocks of 5G (and cooperations among them) to provide versatile, flexible, reconfigurable, efficient operations for HW/SW platforms. The development of this concept entails many system design challenges that will be solved through disruptive technologies. E.g., analogue components to enable massive MIMO for mmWave, full duplex (simultaneous transmission and reception) for 5G waveforms, or reconfigurable SW architectures with interface abstractions for flexible control and management mechanisms across heterogeneous wireless devices and access networks. Flex5Gware will evaluate and demonstrate the developed 5G technologies, in terms of proofs-of-concept, which will be showcased in a demonstration event where all the partners in the consortium will participate. The Flex5Gware consortium includes large industry leaders from infrastructure providers (ALUD, EAB and NEC), semiconductor manufacturers (IMC) and network operators (TI) as well as leading research institutions and academia and is reinforced with the participation of three SMEs. This powerful consortium, together with the measures detailed in the proposal, ensure a huge impact of the Flex5Gware results.

Keywords: 5g wireless,hardware,software,5g key building blocks,rf front ends and antennas,mixed signal technologies,digital front end and hw,sw function split,sw modules and functions,5gpoc
Bottom up biophysics approach to resolve the looping structure of chromosomes (LoopingDNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

How is DNA spatially organized in our cells? What are the mechanisms that shape chromosomes and how does their 3D architecture direct their function? Recent years have shown that the spatial structure of the genome is of pivotal importance for its biological function. Yet, the basic physics of the formation and regulation of its 3D structure has remained unclear. This proposal aims to understand the fundamental structure of chromosomes using a bottom up biophysics approach, from looping at the single-molecule level to higher levels of complexity. We focus on so-called SMC protein complexes (SMC = Structural Maintenance of Chromosomes). These ring-shaped proteins are a unique new type of molecular motors that can extrude large loops of DNA that are thought to be the basis of chromosome structure. Our group’s recent breakthrough discovery of the looping motor function of condensin SMC paved the way to now answer major open questions, such as the motor mechanism of SMCs; how SMCs handle realistic chromosomal fibers loaded with DNA-binding proteins; how looping relates to gene expression; and whether it is evolutionary conserved from bacteria to man. By answering these questions using single-molecule assays, we will resolve the basic mechanics of the SMC-induced looping of DNA. We will extend this to even build a chromosome from the bottom up, in a ‘genome-in-a-box’ approach where we will take genome-length bare DNA and add SMC protein complexes and other DNA-processing proteins. Such a well-controlled bottom-up approach – which to our knowledge is unique – can be expected to generate a radically new understanding of the physical forces and protein systems that shape chromosomes. We are confident that our powerful single-molecule biophysics tools, in collaboration with working with the world’s best biochemists, will enable to disentangle the fundamental looping architecture of chromosomes that is so essential to all of life.

Keywords: smc protein complexes,single molecule techniques,biophysics,dna loop extrusion,biomolecular motors,dna protein interactions,dna polymer physics,chromosome structure,bottom up approach
SUStainability assessment of ADvanced Energy Systems: towards new methodological approaches (SUSADES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-10
End date: 2019-12-09
Duration (months): 15.0
Total project cost (EUR): 106326.0
EU funding (EUR): 106326.0
Participants: 1
Project status: CLOSED

Answering to the need for more sustainable, more flexible and secure power generation systems, the proposed project aims to develop and apply a methodological framework for the feasibility assessment of novel and existing electricity generation technologies in future energy systems. Specific objectives of the SUSADES project are: (i) to generate simulation models for selected existing and future electricity generation technologies; (ii) to integrate Key Performance Indicators (KPIs) of these modeled technologies in a national electricity model, implemented in LEAP (Long-range Energy Alternatives Planning system); (iii) to propose and formulate an optimization algorithm that allows the establishment of economic and environmental performance targets and benchmarks using prospective modelling results. Within the project, detailed mathematical models of individual components of the selected prospective power systems will be developed. Based on that, a thermodynamic analysis of particular unit processes will be conducted and integration of the models will be made. The systems will be subjected to thermodynamic, environmental and economic analysis as well as to the optimization. This first step will result in defining the Key Performance Indicators which will be incorporated in the Energy System Models (ESM). The KPIs will be further used in a national electricity model, implemented in LEAP. The ESM will be hybridized with the LCA methodology through the integration of relevant life-cycle indicators of the power generation technologies involved in the current and future electricity production mix. As a result, the theoretical numbers for the defined KPIs will be obtained. The optimization will be made with the use of an open-source OSeMOSYS model, integrated with LEAP. The develop tool will allow to evaluate various scenarios of power generation technologies in future energy mix, becoming a valuable instrument for sustainability assessment e.g. for decision-makers.

Keywords: sustainability,energy system model,life cycle assessment,scenario analysis,energy planning
Righting Victim Participation in Transitional Justice (VictPart)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2024-12-31
Duration (months): 66.0
Total project cost (EUR): 1497407.0
EU funding (EUR): 1497407.0
Participants: 1
Project status: SIGNED

The question of how to serve justice, facilitate peaceful transitions and empower victims of past large-scale abuses is about as old as the field of transitional justice (TJ) itself. Increasingly, academics and practitioners are turning to participatory approaches as a promising way to make advances regarding these issues. An oft-cited benefit of victim participation in TJ processes is that it allegedly increases the legitimacy of these processes by rendering them more locally relevant, and that it empowers participants. However, little is known about how to organize this participation in practice or under which conditions alleged benefits (for individual victims-participants or for society at large) are likely to materialize. As a result, participation is often organized in an 'add-victims-and-stir' way, with little critical reflection about potential unforeseen or long-term effects. Because TJ processes often face significant practical, financial and political constraints, it is crucial to better understand how participatory approaches can be developed in ways that contribute to a positive and lasting legacy. The main objective of this project is therefore threefold, (1) to conduct a systematic analysis of the scope, nature, modalities and role of victim participation in transitional justice processes, (2) to study empirically and comparatively how participation shapes victims' experience and understandings of justice and their rights, and (3) to develop a critical victimology framework and establish how this framework can be used to conceptualize victim participation in ways that contribute to TJ's goal of engendering just, stable and secure societies. A multi-disciplinary approach, rooted in legal studies, social psychology, political science, public administration and anthropology is proposed, which allows for a multi-dimensional understanding of these issues, both in academic and in practical terms.

Keywords: victim participation,transitional justice
Simulation of Turbulence and RoughnEss in Additive Manufactured parts (STREAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France,France
Call: Turbulence modeling of heat exchangers and roughness impact (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 604280.0
EU funding (EUR): 604280.0
Participants: 4
Project status: CLOSED

Additive manufacturing (AM) process offers tremendous gains over conventional subtractive manufacturing in heat exchanger design, key issue of thermal engine efficiency. The STREAM project aims at designing novel modeling strategies for the performance prediction of additive-manufactured heat exchangers. The consortium consists in two laboratories CNRS-CORIA and CNRS-LEGI, which have a long experience in high-fidelity multi-physics turbulent flow modeling and TEMISTh, a SME which develops customized solutions for heat exchangers. From the fluid dynamics point of view, AM often introduces important wall roughness, which depends strongly on the manufacturing process itself, and which impacts heat transfer and pressure loss across the device. It is therefore mandatory to design Computational Fluid Dynamics (CFD) models with a sufficient level of accuracy to predict the performances of heat exchangers. RANS (Reynolds-Averaged Navier-Stokes) and LES (Large-Eddy Simulation) are two complementary turbulence modeling approaches that are good candidates for such challenge. In these approaches, wall modeling often relies on statistical analysis, leading to law-of-the-wall models that are widely used in the prediction of internal flows. However, these models need to be extended and validated for wall roughness generated by additive manufacturing. To this aim, STREAM proposes to build a large database of high-fidelity roughness-resolving Large-Eddy Simulations that will be analyzed to derive well-parametrized statistical wall models. An original wall model parametrization will be used that has already been successfully adapted to heat transfers on a turbine blade. The resulting statistical model, usable in both roughness-modeled RANS and LES approaches, will be extensively validated a priori by comparison with the high-fidelity database and a posteriori on classical heat exchanger applications: Fuel-Cooled Oil Cooler, Air-cooled Oil cooler, Surface Air-cooled Oil cooler.

Keywords: roughness,turbulence,modelling,computational fluid dynamics,additive manufacturing
Functional dissection of metabolic checkpoints in lymph node fibroblastic reticular cells (FRC BioEnergetics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Induction and regulation of optimal immune responses depends on the proper functioning of fibroblastic reticular cells (FRCs) of secondary lymphoid organs (SLOs). Energy balance maintained through the choice of ideal metabolic pathways critically influences the performance of immune cells. Currently, the bioenergetic demands of FRCs and how they impinge on their function remain elusive. The overarching goal of this project is to decipher the bioenergetic needs of FRCs in homeostasis and during inflammation and to uncover the critical immunological signals involved in the metabolic shift of FRCs that underpin immune activation. Combination of state-of-the-art models for in vivo FRC targeting, novel methods from quantitative systems biology and molecular perturbation analysis will be utilized to reveal the metabolic landscape supporting optimal FRC function and the induction of immune responses. Specifically, “FRC BioEnergetics” will determine: The bioenergetic profile of homeostatic vs. inflammatory FRCs and identify the metabolic switching necessary to support the transition to immune-activated state of FRCs (Aim 1); Identify the immunological signals that trigger metabolic switching necessary to support FRC activation (Aim 2) and Determine to what extent metabolic regulation of FRC function impacts on global immune responsiveness (Aim 3). The focus of the multidisciplinary research program on metabolic regulation of FRC function as central means for the control of immune responsiveness will reveal novel principles underlying immune homeostasis and immunity. “FRC BioEnergetics” will expand our knowledge of the intricate metabolic regulation of immune cell function, with the final goal to provide novel options to modulate immune responses by targeting FRC metabolism and deliver better immunotherapeutic strategies against infection, cancer and autoimmune disorders.

Keywords: stromal cell biology,immunometabolism,fibroblastic reticular cells,lymph nodes,metabolic switching,bioenergetic profile
Integrated, Intelligent modular power electronic converter (I2MPECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Switzerland,France,France,France,United Kingdom,United Kingdom
Call: Competitiveness of European Aviation through cost efficiency and innovation (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 7180892.51
EU funding (EUR): 6734626.26
Participants: 12
Project status: CLOSED

Increasingly demanding requirements in the transportation industry for higher efficiency and reduced carbon footprint are leading to an ever increasing interest in electrically operated drives which offer significant benefits over their pneumatic or hydraulic counterparts. More electric aircraft technologies with fully electrical actuation and environmental conditioning systems are moving from topics of academic interest to commercial applications. Despite the progress in power electronics and electrical drives, significant advances in power density and reliability are still required before electrical technologies are fully accepted in the aircraft industry. The thermal management of losses generated in the power converters, with the associated requirements for heavy cooling systems, is proving to be the stumbling block for further improvements in power density. Ground-breaking advances in wide band-gap semiconductor materials are promising to deliver significant benefits to power conversion systems with unprecedented levels of power density thanks to considerably reduced losses and high temperature operation, making them ideal building blocks for aerospace power electronics. Leveraging on some of EU best expertise in device manufacture and packaging, components integration, thermal management, converters design, reliability analysis, control and condition monitoring, as well as aircraft power systems, the proposal will demonstrate significant advances of the state of the art in power converters for harsh environments. Innovative 3D device packaging based on planar interconnect technologies with double-sided integrated cooling, will be demonstrated for wide band-gap wire-bond free power semiconductor devices. These technological breakthroughs, coupled with novel methodologies for active thermal management, lifetime testing, health management and prognosis will contribute to unprecedented levels of power density, efficiency and reliability in aerospace application

Keywords: more electric aircraft,power electronics,packaging,integration,high efficiency electric drive,multi purpose use,high power density,condition monitoring,high temperature operation,reliability
Computational Biophotonics for Endoscopic Cancer Diagnosis and Therapy (COMBIOSCOPY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1499699.0
EU funding (EUR): 1256437.5
Participants: 3
Project status: CLOSED

Key challenges in endoscopic tumor diagnosis and therapy consist of the detection and discrimination of malignant tissue as well as the precise navigation of medical instruments. Currently, a low level of sensitivity and specificity in tumor detection and lack of global orientation lead to both over- and undertreatment, tumor recurrence, intra-operative complications, and high costs. The goal of this multidisciplinary project is to revolutionize clinical endoscopic imaging based on the systematic integration of two new but independant fields of research up until this point: Biophotonics and computer-assisted interventions (COMputational BIOphotonics in endoSCOPY). For the first time, quantitative multi-modal imaging biomarkers based on structural and functional data are being developed to enhance the physician’s view by providing information that cannot be seen with the naked eye. To this extent, white light images co-registered with multispectral optical and photoacoustic images will be processed in a combined manner to dynamically reconstruct not only the visible surface in 3D but also subsurface anatomical and functional detail such as 3D vessel topology, blood volume and oxygenation. Spatio-temporal registration of multi-modal data acquired before and during the procedure will enable (1) the highly specific local tissue classification and discrimination based on tissue shape, texture, function and radiological contrast imagery as well as (2) global context-aware instrument guidance. This innovative approach to radiation-free real-time imaging will be implemented and evaluated by means of computer-assisted colonoscopy and laparoscopy. The potential socioeconomic impact of providing high precision minimally-invasive tumor diagnosis and therapy at low cost is extremely high.

Keywords: computer assisted interventions,computer aided surgery,interventional imaging