Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New C-H activation chemistry for complex heterocycle synthesis (CHACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

The discovery of new catalytic processes is one of the pre-eminent drivers of current chemical research. The chemistry of tomorrow must be sustainable, using processes that are quicker, cheaper, cleaner and greener, and it must be innovative – new molecules are in constant demand to power the advances in medicine, materials and agriculture that structure our society. Catalytic chemistry that activates C-H bonds for synthetic manipulation speaks to both sustainability and innovation, offering near complete superiority over classic stoichiometric processes. This proposal presents new ideas for C-H activation that target heteroaromatic molecules, a fundamental class of compound having vast application in chemistry and biology.

Keywords: organic chemistry,c-h activation,palladium catalysis
Magnetic Nanoparticles for Multiplexed Assays for Low and High Molecular Weight Biomarkers (ASSAY FOR BIOMARKERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-03-31
Duration (months): 22.0
Total project cost (EUR): 177374.2
EU funding (EUR): 177374.2
Participants: 1
Project status: CLOSED

The application for the FP7-PEOPLE-2009-IEF is to support a move of a postdoctoral researcher to University College Dublin, UCD. The researcher to date has published in 16 peer reviewed journals and has a current h-index of 8. With the expert training and opportunities in place at UCD, the award of the fellowship will build upon the successful start of his academic career and deliver him to a full time academic position. This research proposal outlines a new technique capable of screening biomarkers with the capability of working directly in biological samples. The benefits of monitoring biomarkers lie in their ability to reveal signs of disease before the onset of major symptoms. The proposed technique will involve synthesizing nanoparticles to contain paramagnetic and optical properties, that will then be functionalized with aptamers/ or antibodies. These functionalized particles will capture the biomarkers directly from solution, and in conjunction with non-linear magnetophoretic separation, NLM, will allow the quick separation and detection by exploiting the particles superparamagnetic and optical properties, creating a new diagnostic technology. The experimental details will deliver a single process capable of capturing the analyte as well as performing the initial sample purification and pre-concentration stage that screens multiple biomarkers for several diseases across a wide range of molecular weights and functionalities. It will deliver benefits of being both a multiplexed technique that also offers a highly desirable tagless detection mechanism. The training that accompanies this will ensure the fellow has a broad scientific understanding, crossing several scientific fields delivering an interdisciplinary research approach. When combined with the support infrastructure in place at UCD, will deliver outstanding career enhancement prospects to the applicant, delivering a new diagnostic technique to enhance the European research portfolio.

Keywords: antibodies,aptamers,assay,biomarkers,diagnostic,nonlinear magnetophoretic,nanoparticles,separation,superparamagnetic,template deposition,surface plasmon resonance.
An Environmental History of Haiti (1492-present) (HAITI'S ENVIRONMENT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-06-07
End date: 2014-06-06
Duration (months): 36.0
Total project cost (EUR): 247063.8
EU funding (EUR): 247063.8
Participants: 1
Project status: CLOSED

This project will aim to reinforce the international dimension of the applicant&apos;s career and give him the opportunity to be professionally trained in the United States as an Environmental Historian. He will acquire new knowledge and research methods and will return to the EU well-equipped to teach and publish in this relatively new field of study, still under-represented in Europe. The project will fill in a void in scholarly research by producing the first Environmental History of Haiti since 1492. The monograph will attempt to explain why Haiti is now one of the most environmentally degraded and poorest countries in the world, whilst it was in the 18th century a luxuriant island and the leading exporter of sugar in America. Existing academic works on Haiti are mostly centred on one particular aspect of the history of the country, are circumscribed in time and almost always neglect the environment when attempting to explain the nation&apos;s tortured past. This project&apos;s working hypothesis is that environmental factors have played a much more significant role than is currently recognized. For example, the pattern of population and colonisation of the island, which has played such a significant role in the country’s history, was severely constrained not only by the slave-based plantation economy, but also by the work of humble mosquitoes, vectors of yellow fever and malaria. Environmental degradation today (deforestation, soil erosion…) also plays a crucial role in the chronic instability of the country. The project will be carried out in Washington D.C. and Paris under the guidance of two leading scholars in the field, John McNeill (Georgetown University) and Genevieve Massard-Guilbaud (EHESS). The applicant will take advantage of the rich resources available for his research both in Washington (Library of Congress, National Archives) and in Paris (Archives and Bibliothèque Nationales), and will also benefit from the intellectual stimulus in both host institutions.

Keywords: humanities,natural sciences,history,haiti,environment,west indies,colonial
Greek fantastic literature: a case of censorship in a European literary canon (GFL - CCELC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 223537.9
EU funding (EUR): 223537.9
Participants: 1
Project status: CLOSED

Rarely have Modern Greek Studies taken into consideration any other than “serious” or mainstream works in order to establish a national “canon” and to analyze trends, worldviews or discursive strategies in Greek literature. Although disregarded by scholars and critique, there are some specific genres at the margins of official Greek literature that can reveal many things about national literature and related discursive strategies. The purpose of this project is to research one of the mentioned genres: Greek fantastic literature, which not only will demonstrate to be important by itself, but also to constitute an efficient departure for studying the processes of canon formation and literary censorship that exist within the institution of Greek literature and, at some extent, construct it. The project implies, first of all, a search for a corpus of fantastic works in Greek in the last two centuries. These works will need subsequently to be analyzed according to rigorous methodological tools (comparative literature, poststructuralist approaches, cultural studies). We will focus on some questions inherent in the existence of a Greek fantastic genre: the limits of national literature, the struggle between hegemonic and counterhegemonic discourses (in a historical, political, ontological or sexual sense), and the images of Greece and the Greeks supplied by these works. More specifically, the main goal of the project is to find out which are the strategies implied in the apparent censorship suffered by fantastic literature in the Greek canon, and their relationship with, on the one hand, the nationalist discourses that have often dominated and even determined Modern Greek culture, and, on the other, the role of literature as one of the most important institutions for the construction of a Modern Greek identity and nation. Modern Greek literature as a whole, and as a social function, will therefore be re-examined from the innovative point of view of a genre at the margins.

Keywords: fantastic literature,modern greek literature,cultural studies,social criticism,literary canons,genre studies
Mechanism of action of anti-fungals against mycotoxigenic species: from molecular to phenotypic efficacy (ANTIFUNGALVSMYCOTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

The consumption of mycotoxin-contaminated commodities is related to several acute and chronic diseases in humans. Consumer pressure in Europe has resulted in efforts to find effective natural compounds to substitute existing food grade preservatives to control the growth of mycotoxigenic food spoilage moulds. In this project the research of the functional relationship between natural anti-fungals, direct impact on the key mycotoxin clusters genes as well as relating this to phenotypic mycotoxin production will facilitate the understanding of their differential mechanisms of action. A limited number of antifungal natural compounds have shown good efficacy against mycotoxigenic spoilage moulds (Penicillium, Aspergillus and Fusarium). However, inhibition of mycotoxin production is affected by environmental conditions and in some cases low levels of these compounds have been found to stimulate mycotoxins production (ochratoxin, deoxynivalenol, fumonisins). This study will use multidisciplinary tools at a molecular, cellular, fungal morphology and colony structure level, to understand the differential way of action of fungistatics and fungicides against key mycotoxigenic species under different environmental regimes. Techniques as LC-MS, RT-PCR, fluorescence staining and analysis by confocal microscopy and flow cytometry, will be applied. The results generated will provide a method for better understanding the mechanisms of action as well as providing guidelines for the best GRAS chemicals to use under different environmental condition to prevent contamination by such natural toxins.

Keywords: preservatives,antioxidants,fungicides,mycotoxin,aflatoxins,ochratoxin,trichothecenes,chromatography,confocal microscopy,flow cytometry
Risk and Equity in Climate Change Problems (RISKEQCC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2011-01-31
Duration (months): 9.0
Total project cost (EUR): 119950.0
EU funding (EUR): 119950.0
Participants: 1
Project status: CLOSED

The issue of climate change is becoming more and more prominent in the public debate. It raises several ethical issues in terms of intergenerational equity and global justice. Standard cost-benefit analysis neglects inequalities, assuming that appropriate redistributions are possible, but such redistributions are unlikely at the large temporal and regional scales involved in climate change issues. Hence it is of particular importance to develop evaluation methods to assess the distributional impact of climate policies. There are several challenges that must be met to develop such methods. A first problem is the question of discounting. Standard discounting methods violate intergenerational equity. Deriving an index of intergenerational equity that accounts for discounting is therefore a theoretical challenge. A second issue is that the policies under consideration have uncertain consequences, because the exact value of the parameters in the climate model are not known for sure. Hence inequalities between regions are uncertain and uncertainties are unevenly distributed among regions. These phenomena, which have largely been overlooked so far, seem particularly relevant for policy-making. One aim of the proposed research project is to to develop new evaluation methods to assess intergenerational and risk inequalities. To do so, we can rely on recent developments in decision and welfare theories. At the same time, the project aims at showing the relevance of the proposed methods. For this purpose, we will rely on the CWS climate-economy integrated assessment model, that will have to be adapted to take into account risks and adaptation policies. This would be the occasion to deepen our knowledge of the relative merits of alternative policies aiming at reducing or mitigating the effects of greenhouse gas emissions, especially in terms of inequality. The wider long-term objective will be to improve policy evaluation and to help decision-making.

Keywords: ecological economics,economic theory,economic planning,inequality measurement,risk
Articular Contact Mechanics with Application to Early Diagnosis of Osteoarthritis: Asymptotic Modelling of Biomechanical Contact Phenomena Under Dynamic and Impact Loading (OA AM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 231089.6
EU funding (EUR): 231089.6
Participants: 1
Project status: CLOSED

Around a quarter of the European population aged over 60 suffer from disability due to osteoarthritis (OA). The onset, progression, and severity of this degenerative joint disease is crucially influenced and controlled by mechanical factors in the articular cartilage system. Today, the ever-increasing complexity of mathematical models for articular contact mechanics comes in acute contradiction with the scientific striving for clear understanding of the underlying principles of AO pathology. One of the much used ways to simplify mathematical models is asymptotic modelling (AM), which is an asymptotic analysis based mathematical modelling approach to investigate complex multi-parametric and multidimensional systems. This proposal seeks to develop an advanced AM methodology for describing contact mechanics of articular joints under quasi-static, dynamic, and impact loading. The main research objectives are (1) develop elaborate multi-level asymptotic models for analytical evaluation of the sensitivity of the crucial parameters of articular contact mechanics due to small variations in thicknesses and biophysical microstructural properties of the contacting articular cartilage layers, including microcracking in articular calcified cartilage and OA-associated changes in the underlying bone tissue; (2) develop mathematical and computational models for time-dependent nanoindentation of articular cartilage suitable for a new recently emerged methodology for in situ health monitoring of articular cartilage and early detection of OA using indentation type atomic force microscopy; (3) implement the expected results of mathematical modelling and asymptotic analysis into computational simulation software. The proposed mathematical modelling project is intended to be carried out in close collaboration with the biomechanics research group, which has already established links with the target population of patients suffering from OA and the clinicians treating them.

Keywords: biomaterial engineering,biomechanics,biomathematics,engineering mathematics
Explaining international adoption of high-technology products with indirect network effects. (INT DIFF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 153548.8
EU funding (EUR): 153548.8
Participants: 1
Project status: CLOSED

This project studies the international adoption process of high technology products with indirect network effects. The term indirect network effect refers to the increased utility of a hardware product as the availability of software increases. In turn, the provision of new software products is encouraged as more and more people adopt the hardware product (see e.g. Cottrell and Koput, 1998). Examples of such products are PCs and software applications, DVD-players and DVD movies, or smartphones and applications. The project tries to find an answer to the question why the adoption of high tech products with indirect network effects is much faster in some countries than in others. One could think of many potential explanation, including the economic situation of a country as well as its cultural, political or geographic situation. It is important, however, both for policy makers as for the industry, to get a better understanding of exactly which factors are important. We propose a new method that is able to identify the main drivers of the international adoption process. This is challenging from a methodological point of view given (1) the feedback relationship between the hardware adoption and the software provision, and (2) the high-dimensional character of the phenomenon. That is, we study the adoption process in an international setting (many countries) and do not want to exclude potential driving factors (many variables).

Keywords: knowledge economy,international marketing,econometrics,macroeconomics
Salva nos, Domine: A Study of Chanted Confraternity Liturgies and Their Social Contexts in the Southern Low Countries, 1300-1550. (CONFLIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 159100.0
EU funding (EUR): 159100.0
Participants: 1
Project status: CLOSED

This project is a multidisciplinary study of the music and religious practices of lay communities in the Southern Low Countries in the late Middle Ages and early Renaissance. Such communities, which include trade guilds, devotional confraternities, and selected chivalric orders, formed a central part of daily medieval life, especially for tradespeople and merchants. Very little is known about the role of music, in particular Gregorian chant, in the devotional practices of these close knit communities, or the extent to which their members actively participated in the creation and performance of them. The present study will result in the first multidisciplinary monograph on chant and liturgical practices of confraternities in the Southern Low Countries, and will provide unique insight into the construction of their devotions through the application of musicological, literary (philological), and historical methods. The use of these methods together creates a new perspective on the liturgy, which views chant as cultural production, inextricably linked to traditions in devotional practices and local belief systems. This perspective is vital to our modern understanding of the worldview of the medieval laity. The results of this project will actively contribute to the preservation and promotion of European cultural heritage in three countries: Belgium, France, and the Netherlands.

Keywords: humanities,music history,medieval history
HARMONIC GENERATION IN EXTREME ULTRAVIOLET REGION THROUGH THE INTERACTION OF SHORT LASER PULSES WITH LOW-EXCITED LASER-PRODUCED PLASMA AND GAS JETS (HARMONICS-PLASMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-11-03
End date: 2012-11-02
Duration (months): 24.0
Total project cost (EUR): 240289.6
EU funding (EUR): 240289.6
Participants: 1
Project status: CLOSED

High-order harmonic generation (HHG) is an increasingly used and promising technique for achieving the extreme ultraviolet (XUV) spectral range with highest brightness, short pulse duration, and coherence. Extensive studies of this phenomenon have been mostly carried out using jets of neutral atomic gas, which have resulted in novel coherent XUV sources. However, typically observed high-order harmonics presently have the disadvantage of low conversion efficiency (10-6). This is problematic for many potential applications of HHG radiation including XUV coherent diffraction imaging, time-resolved measurements, and seeding of Free Electron Lasers. Recent studies have shown that this weakness can be partially overcome by using the ablated plasma as a nonlinear medium. An especially interesting observation, unique for harmonics originated both from gas jets, surfaces, or plasma, is the enhancement of a single harmonic, attributed to resonance with a strong radiative transition. In this way, conversion efficiencies higher than 10-5 from the pump laser radiation to the harmonics in the plateau range have been reported. The project is aimed at the enhancement of HHG efficiency from laser ablation produced on the surfaces of solid-state materials and comparison with HHG from gas jets. The milestones of the proposed investigations include (a) analysis and optimization of harmonic generation from laser plasma produced on the surface of various targets, (b) search of resonance-induced enhancement of single harmonic in the XUV range, (c) harmonic generation from the laser plumes containing nanoclusters, (d) search of the continuum in the harmonic emission near the cutoff (a characteristic signature for attosecond pulse generation), and (e) HHG from gas jets and comparison with the HHG from laser plasma. As a result of project, further improvements of the harmonic efficiency in the XUV range through the HHG from laser plasma and gas jets will be achieved.

Keywords: high-order harmonic generation of laser radiation,laser plasma