Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Erwin Schroedinger Program (SCHROEDINGER FELLOWS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2011-COFUND, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 8918275.0
EU funding (EUR): 3567310.0
Participants: 1
Project status: CLOSED

With this proposal the FWF applies for COFUND of the Erwin Schroedinger Program the largest Outgoing -Program in Austria for basic research at postdoc level open to all disciplines and destinations. According to the objectives of the COFUND-action the program aims to support researchers to work abroad at leading research institutions and on leading research programs to open up new areas of knowledge, new scientific approaches, methods and techniques. In this way it helps the fellows broading and deepening their competence and establishing long lasting international cooperations. The very high impact on career development of the Schroedinger fellows has been shown in the program evaluation. With the help of the Cofund it was possible to improve the program with the possibility to apply also for a reintegration-phase and to facilitate the critical return phase. The FWF hopes to counter on a long turn the brain drain from Austria and consequently from the ERA. In a next step the FWF eliminated the age limit and expanded in this way the group of the potential applicants.

Keywords: health sciences,humanities,natural sciences,physical sciences,social sciences,technological sciences
From materials science and engineering to innovation for Europe. (M-ERA.NET)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Coordination and support actions
Partnership: M-ERA.NET (ERA-NET)
Countries involved: Austria,Belgium,Belgium,Cyprus,Germany,Germany,Germany,Estonia,Spain,Spain,Spain,Spain,Finland,France,Hungary,Israel,Iceland,Italy,Lithuania,Luxembourg,Latvia,Netherlands,Norway,Poland,Portugal,Romania,Sweden,Slovenia,Slovakia,Türkiye,France,Italy,United Kingdom
Call:  (FP7-ERANET-2011-RTD, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 3490613.42
EU funding (EUR): 3000000.0
Participants: 40
Project status: CLOSED

M-ERA.NET will be a real tool for developing a strong European RTD community on materials science and engineering and for supporting the European economy with respect to the challenges of the 21st century. M-ERA.NET will be a highly ambitious network involving a majority of European key players in national funding of materials science and engineering. M-ERA.NET will replace a number of smaller previous ERA-NETs and cover the materials domain with an innovative and flexible umbrella concept for one single ERA-NET contract. M-ERA.NET will set up a multi-annual policy for joint programming targeted at the whole innovation cycle. Cooperation at an international level will enable the European RTD community to access world leading knowledge. It is our mission to - strengthen the status of the European RTD community and economy in materials sciences and engineering; - mobilise critical mass of national and regional funding for transnational RTD cooperation in materials science and engineering, thereby achieving a very large leverage effect of the requested FP7 funding; - set up a novel umberlla concept for cooperation to react to emerging needs and to allow coverage of future topics in related thematic areas; - establish strategic programming of joint activities, addressing societal and technological challenges in an interdisciplinary approach; - support the exploitation of created knowledge along the whole innovation chain; - enable enlarged research cooperation within the EU member states and associated states; - establish international cooperation with partners outside Europe; - exploit the novel developments in a durable, long term cooperation between funding organisations.

Keywords: materials,era-net,national programme,international cooperation
Molecular mechanisms involved in skeletal muscle repair and muscular dystrophy. (MUSCLE REPAIR MDX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The objective of this proposal is to define the role of histone deacetylase 4 (HDAC4) and myocyte enhancer factor 2 (MEF2) in muscle regeneration and dystrophy. In response to injury, skeletal muscle activates orchestrated molecular mechanisms to restore muscle architecture and functionality. Our preliminary data showed that skeletal muscle from mice lacking HDAC4, an inhibitor of the myogenic factor MEF2, regenerates better than that of control mice following injury. MEF2 activity is triggered in healthy myofibers surrounding the injured area, suggesting a potential role of MEF2 in paracrine regulation of adult muscle regeneration. We demonstrated that MEF2 controls the expression of caveolin3, an inhibitor of myostatin, a negative regulator of muscle mass. In this proposal, we plan to define the role of HDAC4 in muscle regeneration by identifying the targets responsible for the improved regeneration observed in HDAC4 null mice. We intend to study how HDAC4 regulates satellite cell proliferation and differentiation. In order to identify secreted factors that may contribute to the improved regeneration in HDAC4 null mice, we plan to perform a proteomic analysis on secretomes from HDAC4 null and control myofibers. Muscular dystrophies are a hereditary myopathies characterized by progressive muscle degeneration and weakness. Promoting muscle repair has been shown to be therapeutically beneficial for muscular dystrophy. We intend to study the role of HDAC4 in muscular dystrophy by characterizing mdx mice lacking HDAC4 in skeletal muscle. We will define MEF2 activity and we will determine target genes controlled by HDAC4 in muscular dystrophy. By delineating the role of HDAC4 in skeletal muscle regeneration and dystrophy, we will provide an experimental framework for developing new drugs to improve muscle repair and ameliorate muscular dystrophy.

Keywords: health sciences
Incorporation of multiscale tissue-specific properties into musculoskeletal finite element modelling (TISSSPECBONEFEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2014-02-28
Duration (months): 30.0
Total project cost (EUR): 62500.0
EU funding (EUR): 62500.0
Participants: 1
Project status: CLOSED

Despite the remarkable advances in musculoskeletal biomechanics during the last decade, realistic physiological tissue-level strain fields in whole bones are not yet known as these cannot be measured experimentally and the numerical simulations targeting this aim either do not include microstructural and elastic information or investigate a sub-volume with simplified loading. However, this knowledge would be essential for unravelling the relation of micro-structure and function, and for understanding the rules dictating process of mechanosensation for bone remodelling and healing. The aims of this project are to (I) assess the realistic physiological mechanical environment in cortical bone tissue with previously unmatched accuracy to understand the functional adaptation of the intact microstructure and (II) use this knowledge to investigate the variations observed in altered conditions, e.g. fracture healing. These goals will be achieved using and unprecedented combination of tools and data of an ovine lower limb model available at the research groups and European collaborators of the host. In Phase 1, organ-scale homogenized finite element (FE) models will be developed which include tissue-specific, experimentally assessed anisotropic micro-elastic properties via a multi-scale homogenization approach and physiologically relevant loading histories from musculoskeletal models to compute macro-scale strain and stress fields. In Phase 2, these local macro-scale stresses will be applied on micro-FE models of experimentally assessed meso-scale tissue volumes to compute the micro-scale strains and stresses. In Phase 3 the developed approaches will be incorporated into a numerical framework suitable for the investigation of altered conditions, e.g. fractures. This will be applied on an established sheep osteotomy model, which is anticipated to elucidate the optimum strain levels required to promote the endogenous healing process, which is of direct clinical relevance.

Keywords: biomedical engineering,simulation engineering
Non-Radioactive Molecular Imaging-Driven Drug Development in Oncology (ONQVIEW)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: Netherlands,Netherlands
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2499989.4
EU funding (EUR): 2499989.4
Participants: 2
Project status: CLOSED

Cancer is a leading cause of death worldwide. Fortunately an abundance of cancer drugs are becoming available; the challenge now is to select the most promising. Integrated cancer research and biomarker-driven adaptive and hypothesis-testing clinical trials are imperative. Many tumor characteristics can now be visualized simultaneously, but the necessary tracers have hardly been explored clinically. In the onQview program, we aim to create a drug development strategy based on a novel non-radioactive molecular imaging approach to guide patient-tailored selection of drugs, to measure in vivo drug and tumor behavior, and to allow dynamic treatment tuning. Our extensive (pre)clinical experience with molecular imaging and drug development is hereby merged with our unique infrastructure, including lasers, microscopes, and advanced detection systems for non-ionizing electromagnetic waves, for optical and photoacoustic imaging modalities. We will develop novel non-radioactive tracers based on HER-targeting drugs in breast and colon cancer, and use molecular imaging to track the drugs and corresponding effect sensors that visualize targeting effects. This approach will allow dynamic treatment tuning in pre-clinical (animal) experiments. We will also advance the implementation of optical and photoacoustic imaging with optimized measurement techniques and quantification strategies that will allow testing of the new tracers in breast/colon cancer models. Two tracers will be produced for human use and evaluated in clinical studies that enable visualization of drug behavior, drug targets and drug effects in relation to the HER family in breast and colon cancer.

Keywords: drug development,cancer,molecular imaging,translational,optical,photoacoustic imaging
Ambgiuity, Data and Preferences for Information - Theory and Applications (AMBIGUITY AND DATA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-15
End date: 2013-09-14
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We study decision making informed by data. We examine the relation between objective information provided by data and decision maker's beliefs about uncertain outcomes. We also study the evaluation of information by economic agents. We then apply the derived theoretical insights to models of technological adaptation to climate change and to a study of market participation and market structure. We start by providing a representation of preferences when decisions are informed by data. The representation captures the idea that information from data is perceived as ambiguous. We identify the decision maker's beliefs which combine the objective information in the data (frequency, number and type of observations) with the decision maker's subjective characteristics (perception of similarity and perception of ambiguity). We determine the decision maker's degrees of optimism and pessimism and relate them to his preferences for precision of information. This allows us to derive the value of information. Next, we apply the representation to a model of technological adaptation in response to a change in climate conditions. We study the role of agent heterogeneity in the process of adoption. By experimenting with new technologies, optimists provide the public good of information, but also obtain lower average returns. Pessimists use this information to choose the optimal technology in the long-run. When the share of optimists is low, steady states are inefficient. We study the impact of subsidies for early adopters and provision of additional information on successful adoption. The representation is also used to model market participation decisions when markets differ w.r.t. the quality of information they provide. Agents self-select into markets based on their preferences for information precision. This leads to distinct dynamics of prices and allocations in markets providing different information. We study implications for the regulation of information provision in markets.

Keywords: social sciences,decision theory,uncertainty,ambiguity,data,case-based decisions,information,technology adoption,climate change,market structure,economics,economic theory
Monitoring and Modelling of Stratospheric Aerosols with a Focus on the Impact of Volcanic Eruptions (MIMOSA-5)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2016-03-02
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The MIMOSA-5 project aspires to a better understanding, modelling and characterization of stratospheric aerosols and of their effect on atmospheric properties using the most recent observations and scientific results. The project also seeks to study and quantify the impact of major volcanic eruptions on the physico-chemistry and dynamics of the stratosphere, the influence of stratospheric aerosols formation on climate change, and the atmospheric consequences of the interaction between these effects. The most important segment of the project is devoted to the development and extension of the three-dimensional microphysical/transport Model for STRatospheric Aerosols (MOSTRA). A significant improvement to implement is the development of a pre-processing tool deriving the most reliable aerosol field at full grid from single/multiple data sets, including extinction or size information. The scope of such a development goes beyond the stratospheric aerosol aspects and has many applications in data retrieval and in atmospheric and climate modelling. Furthermore, the microphysical module will be extended to include processes such as condensation/evaporation, nucleation but also photo- or gravito-phoresis and the addition of nonvolcanic aerosols (soot, meteoritic dusts). The simulation of volcanic eruptions will also be undertaken. The second part of the project consists in improving the quantification of aerosol radiative properties using satellite measurements. The main task will be the development of a climatology of stratospheric aerosol extinction and optical depth from the GOMOS instrument and the implementation of stratospheric corrections for tropospheric measurements. The results of these accomplishments will serve both the modelling activities and the ESA project Aerosol_CCI, a pan-European effort which aims at an enhanced characterization of aerosols both in the troposphere and in the stratosphere by the synergetic use of multiple spaceborne experiments.

Keywords: atmospheric sciences,aeronomy,aerosol characterization,aerosol modelling,climate,volcanic eruptions
Financial Development, Factor Misallocation and Total Factor Productivity (FINMIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project aims to develop a quantitative macroeconomic model to study the effects of financial development on factor allocation and macroeconomic performance. We pursue to answer how financial development influences the joint determination of investment finance and capital-labour ratio choice for European based companies. The findings in this project will shed light on the importance of financial constraints for the allocational efficiency of factor inputs across production firms and in turn the role of financial development policies in explaining the total factor productivity (TFP) differences across European economies. The proposed project has four main objectives. Our first objective is to construct a general equilibrium macro model and derive theoretical implications to answer the question whether financial development improves the allocational efficiency of capital-labour ratio across different production units and affect industry total factor productivity. By applying dynamic panel data estimation techniques for a large sample of European firms from various countries we will also empirically test whether the variations in the level of financial development affects the sensitivity of firm level capital labour ratio with respect to balance sheet conditions. Our final objective in the project is to conduct a quantitative macro analysis and explore whether the distortions in firm level capital-labour choice have quantitatively significant implications for the industry wide misallocation of factors of production and industry total factor productivity. For this purpose, we will run counterfactual policy experiments to measure the variations in the sensitivity of capital labour choice with respect to balance sheet conditions at the firm level and the TFP gains at the industry level in response to the variations in financial development policies conducted in different European countries.

Keywords: economics of development,macroeconomics,total factor productivity,misallocation of capital and labour,corporate investment,financial constraints
Is there a limit to yield? (YIELD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Israel
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Plant breeders are challenged with sustaining global crop improvements. Is there a limit to crop yield? This project will address this central question using processing tomatoes as a model for a mechanized crop. By integrating in a single web-based platform of ‘Phenom Networks’ a broad germplasm base, deep phenotypes, and multiple genome sequences of tomato species, we will identify the genes and mechanisms that dictate crop productivity and implement them in the creation of next generation F1 hybrids. Our work is founded on our years of efforts to establish the following integrated genetic pillars: 1) The tomato genome revealed SNPs for broader marker-assisted selection between cultivated parents and untapped diversity from closely-related red-fruited ancestors. We will develop new elite parental lines into which all discovered traits will be introduced. 2) We will enrich the narrow genetic base of modern processing tomato by pyramiding recessive, additive, dominant and overdominant QTL from six wild species introgression lines (ILs) and field-test them in diverse environments. 3) By producing hybrids with ‘recessive’ deleterious mutants we have identified heterosis genes that increase yield by ~50%; these will be combined with the IL QTL. 4) Finally, we will focus on newly discovered “stability QTL” that significantly improve the reproducibility of yield effects by canalizing this phenotype in spite of environmental perturbations. This multi-faceted integrated tomato breeding effort will unite classical and genomics assisted methods with statistical genetics to demonstrate that yield barriers of the leading commercial hybrids are only there to be broken. We will clone the genes responsible for yield, domestication, heterosis, epistasis and canalization and explore their molecular action. I expect that the breeding concepts and methods developed through this project will lead the way to increased productivity of crops that are important for global food security.

Keywords: plant breeding