Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From endosymbiont to organelle: Mechanisms of cellular integration between Paulinella and its chromatophores (CHROMATOPHORES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

The endosymbiotic integration of cyanobacteria within Eukaryotes was one of the pivotal evolutionary transitions. This transition, however, is difficult to study because modern plastids represent highly derived ‘end-states’ and are not transitionary; we know, therefore, very little about the mechanisms involved. Primary plastid endosymbiosis has occurred only twice: once in the ancestor of Archaeplastida and once independently in the amoeba Paulinella. Each Paulinella cell houses two chromatophores, which are photosynthetic units that resemble plastids yet are more closely related to cyanobacteria. Genetic studies of Paulinella and its cyanobacterial-derived chromatophores revealed it is an intermediary in the evolution of a photosynthetic organelle. Studying Paulinella, therefore, offers unique insight into the mechanistic processes of plastid integration. Despite our growing genetic knowledge, little is known about the integration of the chromatophores in terms of their cellular physiology. In this proposal, I aim to address this by exploring this unique association at the metabolomic, transcriptomic and proteomic levels. First, I plan to characterise the metabolites exchanged between the cell and chromatophores using an isotope-labelling metabolic experiment (objective 1). Second, I will study the coordinated light response of the nucleus and chromatophore at the transcriptional, metabolic, and protein level (objective 2). Finally, I will perform a long-term evolution experiment to expose Paulinella chromatophora to high and fluctuating light regimes to test whether its light regulation can evolve in response to different light environments (objective 3). The outcomes will provide insight into the molecular mechanisms that facilitate the integration of the chromatophores within Paulinella. This in turn will aid our understanding of the acquisition and integration of plastids, and the evolutionary trajectory from endosymbiont to organelle.

Keywords: organellogenesis,endosymbiosis,experimental evolution,metabolomics,transcriptomics,proteomics
A Path Towards Ethical Spectatorship (APTES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

The project “A Path Towards Ethical Spectatorship” will analyze ethical approaches to media consumption, developing a theory and a practice of individual ethical engagement with entertainment. Crucially, this will be addressed from the perspective of the audience member, rather than society at large, so displacing the traditional focus on the ethics of the author of the content. Grounded in 20th- and 21st-century philosophical and sociologic analyses of the ways in which meaning is constructed, found, and extracted from the materials we read, listen to, and consume, “A Path towards Ethical Spectatorship” will build upon the researcher’s decade-long work on Inheritance and Legacy in the cultural space. Adapting the framework of reception theory to the sphere of contemporary entertainment media, the project will create a new model for the critical discussion of ethical spectatorship for secondary schools that will be presented to two of the schools involved in the ACCESS UCC Plus programme. Upon analysis of the results of these activities, the model lesson plan on ethical spectatorship will be perfected and made available to schools beyond Cork, as well as to members of the general public in their lifelong learning. The goal is to provide terminology and conceptualization to help the audience make sense of instances of cancel culture, author denunciation, and cultural boycotts, and to understand whether these correspond to a responsibility of the individual audience member as they participate to the development of an inclusive and peaceful society.
Data loss: the politics of disappearance, destruction and dispossession in digital societies (DALOSS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1491083.0
EU funding (EUR): 1491083.0
Participants: 2
Project status: SIGNED

The objective of Data Loss: the politics of disappearance, destruction, dispossession in digital societies (DALOSS) is to empirically demonstrate data loss as an integral dynamic within the current turn to digitization and big data, with deep-seated societal and political implications for the ongoing development of digital information ecologies. DALOSS examines data loss across three archival regimes – the internet, European bureaucracies, and social media platforms. It provides the first systematic study of data loss, offering novel and important insights for the future of European data politics. This project employs an original methodology combining ethnographic and digital methods, including digital forensics, counter-archiving and linkrot scoping. On this basis, DALOSS pioneers a new interdisciplinary approach, which brings together different tracks of theory within Critical Data Studies and Critical Archival Studies. This approach enables distinct but mutually interconnected dynamics of data loss – disappearance, destruction and dispossession – to be studied within a common analytical-theoretical framework. The analysis will offer unique insights into data loss as part of ongoing digitization and datafication processes, and the political, social and infrastructural implications of this phenomenon. The breakthrough potential of DALOSS is two-fold. By shifting the focus in big data discourses from accumulation to loss, this project establishes an entirely new and societally important research agenda of general relevance to scholars working on big data within the humanities and social sciences. Second, by situating data loss within the broader intellectual histories of loss and technology, the project develops a theoretical apparatus for understanding data loss not merely as technical challenges, but also as a fundamental cultural and political condition.

Keywords: big data,cultural heritage,cultural memory,social memory,data politics,knowledge infrastructures,data justice,cultural theory,datafication,loss,destruction,dispossession,deletion,internet history,data capitalism,deaccessioning
Developing Talent in Science: Breaking the Gifted Education Taboo (DeTaSci)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-03
End date: 2027-08-02
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

The proposed project ‘Developing talent in science: Breaking the gifted education taboo’ seeks to gain new insight of how to address gifted students’ needs in inclusive education (IE) systems. IE systems, described as ’one school for all’ aim to ensure education is accessible for all students, however in reality have focused on the needs of average or lower-achieving students. Gifted education (GE) has been considered elitist, even taboo, and thus the needs of gifted students have been largely neglected in IE policies and schools’ pedagogical strategies. However, individuals gifted in science are key persons to develop responses to societal challenges and to increase innovation and economic competitiveness – if the education system allows them to develop their potential into actual competencies. Neglecting gifted students’ needs may also lead to negative consequences such as underachievement, bullying, and depression. The project will include the perspectives of gifted and regular students, parents and science teachers, and compare the results from Sweden and Finland using mixed methods. It will examine how gifted students’ socioemotional and learning-related needs are supported in inclusive science classrooms and what are gifted students’ and their parents’ lived experiences of specific GE strategies, such as acceleration and grouping – two potentially very effective but understudied and underused strategies in inclusive GE. The project will also examine how science teachers support gifted students’ learning with regard to competence development teachers have had or wish to have, and it seeks to find and showcase the best practices in inclusive GE. The project will produce highly relevant scientific knowledge from the IE context and improve teacher education; strong research-based teacher education manifests in higher science competencies among all students. The impact will extend beyond the Nordic context, as IE has recently generated significant global interest.

Keywords: talent development,gifted education,inclusive education,science education,teacher education
Achieving High-Integrity Voluntary Climate Action (ACHIEVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Greece,Finland,Costa Rica,Sweden,Colombia,United Kingdom
Call: Science for successful, high-integrity voluntary climate initiatives (HORIZON-CL5-2023-D1-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5449736.25
EU funding (EUR): 5449736.25
Participants: 12
Project status: SIGNED

In recent years an unprecedented number of voluntary climate commitments have been made by a wide array of non-state and subnational actors. These voluntary climate actions aim to reduce greenhouse gas emissions and build climate resilience and are crucial for lowering risks of exceeding warming limits. However, the full potential of voluntary climate action can only be realised when integrity-related concerns are overcome. ACHIEVE aims to identify opportunities to strengthen and scale up high-integrity voluntary climate action towards achieving net-zero emissions by mid-century. The project will generate transformative and timely scientific insights on the role, effectiveness and integrity of voluntary climate action including carbon credits; assess the integrity and impacts of such action; analyse how policies and regulations, and high-integrity voluntary climate action can strengthen each other; and use scientific findings to support the scaling up of high-integrity voluntary action. This will be achieved through a highly inter- and transdisciplinary consortium that, from the start, actively engages policymakers and other societal stakeholders in co-creating outcomes that respond to end users’ needs. ACHIEVE is aligned with the Work Programme of Cluster 5, Destination 1 “Climate sciences and responses for the transformation towards climate neutrality” as the project directly contributes to advancing knowledge and providing solutions for climate change specifically on high integrity voluntary climate action. ACHIEVE will develop transition pathways to climate neutrality that integrate voluntary climate action by cities, regions and companies; it will develop novel social science insights for climate action; contribute to better understanding sustainability co-benefits and trade-offs; and increase transparency and trust in voluntary climate action by strengthening integrity and making scientific results easily accessible for different stakeholder groups.

Keywords: voluntary climate action,integrity
Toroidal Propellers for Efficient and Sustainable Aviation (TorPropel)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Greece,Germany,United Kingdom,Spain,France,Czechia,Switzerland
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 2797407.5
EU funding (EUR): 2797407.5
Participants: 9
Project status: SIGNED

The TorPropel aims to advance aircraft propulsion technology by developing and upscaling propellers of toroidal geometry, which are distinguished for their thrust efficiency and noise reduction, utilising advanced carbon composites and state-of-the-art robotic manufacturing processes. This technology has the potential to significantly improve the performance of propeller-driven aircraft, a distinct category of aviation platforms ranging from smaller, piston driven or electric aircraft, to vertical take-off and landing aircraft (VTOLs), unmanned aerial vehicles (UAVs) and even aircraft based on novel designs concepts, such as those featuring distributed propulsion systems. TorPropel sees the development of advanced, aerospace-grade carbon composites alongside the implementation of innovative robotic manufacturing solutions to ensure the achievement of critical performance objectives and a lightweight profile, while also prioritising the propellers' recyclability and repairability. Moreover, the project incorporates sophisticated condition monitoring systems directly into the propeller structure, essential for the real-time assessment of propeller structural health, thus ensuring safety, and considerably reducing the time and costs associated with maintenance. Overall, the TorPropel technology is expected to offer significant improvements in propeller performance, durability, weight, sustainability, and recyclability. The proposed technology is thus expected to have a significant contribution to the scientific field of aircraft propulsion technologies, improving upon the operational effectiveness and environmental sustainability of aviation and also by paving the way for a new era of short-distance air travel that is both quieter and environmentally friendly.

Keywords: toroidal propeller,propulsion technology,advanced carbon fibre reinforced composites,robotic manufacturing,repairable resin,vitrimers,novel manufacturing,fluid dynamics
Exploring neuronal functions of NALCN in health and disease (FIXNALCN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

The resting membrane potential of a cell is a crucial element of signal transduction across cell membranes and temporary changes are the basis of neuronal excitability. The key ions in the process are unequally distributed intra- and extracellularly and ion channels are regulating the transport. One of the main ions involved in this process are sodium ions. The depolarizing sodium influx on the resting membrane potential is primarily mediated by the sodium leak channel (NALCN). The neurological syndromes IHPRF1 and CLIFAHDD originate from NALCN gain-of-function (GOF) and loss-of-function (LOF) mutations, yet patients have overlapping or highly similar symptoms. Therefore, a genotype-phenotype correlation for these symptoms remains unclear. Here, we aim to understand genotype-phenotype correlations by establishing GOF and LOF patient mutations in a human induced pluripotent stem cell system and characterizing these mutants’ impact on neurological activities and comparing these to the wild type. To further expand our understanding of the patient mutations, I will use computational approaches, such as molecular dynamics to characterize NALCN wt compared to the above NALCN missense mutations. Together with the already available clinical data and the data obtained by the Pless lab in heterologous expression systems, this will provide the first comprehensive overview over the detrimental effects of NALCN GOF and LOF mutations. To date, no negative or positive NALCN modulators have been found or developed to fix patient GOF or LOF mutations, respectively. We aim to identify NALCN modulators using both, in silico docking and in vitro TEVC and patch clamp screening approaches, to treat these neurological phenotypes pharmacologically and thus potential drugs to rectify the effects of NALCN dysfunctions, potentially serving as drug therapy for patients suffering from CLIFAHDD and IHPRF.

Keywords: ion channels,electrophysiology,stem cells,voltage gated sodium channels
The PREfrontal CHRONometer for Organizing Working Memory (PRECHRON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 1498531.0
EU funding (EUR): 1498531.0
Participants: 1
Project status: SIGNED

Working memory (WM) is a crucial part of human cognition, yet how the brain maintains and organizes different pieces of information is unresolved. I propose that spike-field coupling (SFC), which is the exact moment in time when a neuron spikes in relation to the surrounding neural oscillation (field), is what organizes WM content. Accordingly, different WM items or features are maintained through SFC at different phases of prefrontal brain oscillations. Metaphorically, the prefrontal oscillation represents a chest, where each phase is a drawer. Neural spiking opens the drawer, allowing specific data to be maintained separately from other data. While this idea is supported by animal research, due to the invasive nature of used methods, evidence in humans is missing. Novel technology, which combines non-invasive neuromodulation (TMS) and physiological recordings (EEG) in a closed-loop system, now enables phase-specific SFC to be non-invasively induced in humans. By leveraging and further developing closed-loop TMS-EEG, PRECHRON will test the idea that the interaction between spiking and oscillation in the prefrontal cortex is the mechanism for separating maintained WM information. Based on previous studies, the focus will be on theta (4-7 Hz) oscillations. PRECHRON will test four independent, non-mutually-exclusive hypotheses: 1. SFC at a resting state (no task) predicts overall WM performance; 2. Phase-specific SFC during a WM task organizes WM of different domains (e.g., verbal and spatial); 3. Phase-specific SFC during a sequential WM task organizes the temporal order of WM items; 4. Phase-specific SFC during a visuospatial WM task organizes the location of WM items. Thus, PRECHRON will explore, for the first time, exactly how the prefrontal cortex maintains various types of WM information. The results will enhance our knowledge of neurophysiological processes in human cognition and open the door to understanding cognitive deficits in brain-related disorders.

Keywords: working memory spike field coupling oscillations transcranial magnetic stimulation electroencephalography
Modern Challenges in Learning Theory (GENERALIZATION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1433750.0
EU funding (EUR): 1433750.0
Participants: 1
Project status: SIGNED

Recent years have witnessed tremendous progress in the field of Machine Learning (ML). Learning algorithms are applied in an ever-increasing variety of contexts, ranging from engineering challenges such as self-driving cars all the way to societal contexts involving private data. These developments pose important challenges (i) Many of the recent breakthroughs demonstrate phenomena that lack explanations, and sometimes even contradict conventional wisdom. One main reason for this is because classical ML theory adopts a worst-case perspective which is too pessimistic to explain practical ML: in reality data is rarely worst-case, and experiments indicate that often much less data is needed than predicted by traditional theory. (ii) The increase in ML applications that involve private and sensitive data highlights the need for algorithms that handle the data responsibly. While this need has been addressed by the field of Differential Privacy (DP), the cost of privacy remains poorly understood: How much more data does private learning require, compared to learning without privacy constraints? Inspired by these challenges, our guiding question is: How much data is needed for learning? Towards answering this question we aim to develop a theory of generalization which complements the traditional theory and is better fit to model real-world learning tasks. We will base it on distribution-, data-, and algorithm-dependent perspectives. These complement the distribution-free worst-case perspective of the classical theory, and are suitable for exploiting specific properties of a given learning task. We will use this theory to study various settings, including supervised, semisupervised, interactive, and private learning. We believe that this research will advance the field in terms of efficiency, reliability, and applicability. Furthermore, our work combines ideas from various areas in computer science and mathematics; we thus expect further impact outside our field.

Keywords: theoretical computer science,statistical learning theory,differentially private learning,mathematical models