Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REstoring myocardial repair capacity via the modulation of MAcrophage-mediated cytoKINe secretion. (REMAKIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Type-2 diabetes (T2D) is a chronic condition strongly associated with cardiovascular diseases, mainly recurrent myocardial infarctions (MI), and generating enormous healthcare cost. Macrophages orchestrate the remodelling of the heart post-MI by efferocytosis-mediated cytokine secretion. Specifically, Mertk-mediated efferocytosis promotes vessel formation, tissue reperfusion and resolution of the inflammatory response via the secretion of the anti-inflammatory cytokines interleukin-10 (IL-10) and Vascular Endothelial Growth Factor-A (VEGF-A). In IR/T2D, efferocytosis-mediated cytokine secretion is impaired, leading to chronic inflammation, adverse post-MI remodelling, recurrent heart failure and excessive mortality. To date, the signalling and intracellular trafficking pathways leading to cytokines secretion are unknown, and the mechanisms of impairment during IR/T2D are unexplored. Previous therapeutic strategies focussed on repairing damaged tissue by injection of progenitor cells or modulating inflammation by cytokine injection, but both strategies gave disappointing results. In this proposal, I will define the mechanisms of efferocytosis-mediated cytokine secretion in macrophages, investigate their defects in IR/T2D and test a novel cell-based therapeutic strategy for improving recovery of T2D patients post-MI and preventing recurrence of cardiac events by restoring cytokine secretion in diabetic macrophages.

Keywords: insulin resistance,type 2 diabetes,myocardial infarction,inflammation,immunomodulation,macrophages,efferocytosis,regulated secretion,intracellular trafficking,cytokines
FUTEBOL: Federated Union of Telecommunications Research Facilities for an EU-Brasil Open Laboratory (FUTEBOL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Belgium,Finland,United Kingdom,Portugal
Call: Experimental Platforms (H2020-EUB-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1499446.0
EU funding (EUR): 1499446.0
Participants: 6
Project status: CLOSED

FUTEBOL composes a federation of research infrastructure in Europe and Brazil, develops a supporting control framework, and conducts experimentation-based research in order to advance the state of telecommunications through the investigation of converged optical/wireless networks. Current wireless trends (cell densification, coordinated communication, massive MIMO) pose a new set of challenges that require the joint consideration of optical and wireless network architectures. These problems are of direct impact to emerging economies such as Brazil, with highly heterogeneous infrastructure capabilities and demand, as well as to more established markets such as the EU, which aims to regain its leadership in the next generation of telecommunication technologies. FUTEBOL establishes the research infrastructure to address these research challenges through innovation over this infrastructure, with a consortium of leading industrial and academic telecommunications institutions. In this capacity, the methodology of the FUTEBOL project is organized into three steps: i) the composition of federated research infrastructure suited for integrated optical/wireless experimentation, ii) the development of a converged control framework to support experimentation on the federated research infrastructure, and iii) the direct advancement of telecommunications through research using the developed research infrastructure and control framework. The steps of FUTEBOL relate to one another in a layered manner: the end-user driven advancement of telecommunications relies on the development of the FUTEBOL converged control framework, which, in turn, requires the composition of federated research infrastructure. In this way, FUTEBOL directly addresses the agreed priority areas of Brazil and Europe cooperation to guide future innovation in the area of ICT. By leveraging and extending the prior work of the FIRE programme and FIBRE project, FUTEBOL expedites industry-centric innovation.

Keywords: wireless and optical networks,research infrastructure,fire,test beds,network architecture,federation,brazil
Artificial intelliGence applied to pRecision farmIng By the use of GNSS and Integrated Technologies (AgriBIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Italy,Ireland,Italy,Greece,Greece,Greece,Portugal,Portugal
Call: EGNSS applications fostering societal resilience and protecting the environment (H2020-SPACE-EGNSS-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 2651390.0
EU funding (EUR): 2155715.0
Participants: 8
Project status: SIGNED

AgriBIT aims to increase the precision, accuracy and continuity of services to deliver improved Precision Agriculture (PA) services to farmers, leading to a reduction in costs through decreased use of inputs (water, energy, fertilisers, pesticides), lower environmental impacts and increased production yields. It positions its innovations both at the level of intervention on the field and the capturing of the effects of PA over time, intelligently exploiting the information acquired before, during and after direct intervention on the field. AgriBIT combines augmented GNSS and EO information with 1) on-field and on-machine sensors and actuators, and 2) expert agricultural knowledge to deliver simple, high precision and continuously available services. It develops and extends advanced Artificial Intelligence algorithms to fully exploit this rich set of inputs to recommend actions to farmers building on past history and present context and to ease their workload through improved automation. AgriBIT delivers operational services (3 GNSS-enabler services, 8 GNSS-enabled services) and 1 European sourced high precision GNSS affordable receiver that cover the complete value chain of PA, from monitoring to application and precise and automated machinery guidance. With 70% of European farmers active in small to medium operations, AgriBIT’s European sourced high precision GNSS receiver at an affordable price is a major technological and societal contribution to Europe’s farming community. AgriBIT delivers collaboration services supporting farmers and service advisors, but also 3rd party developers for whom open interfaces are provided both at service level and as channels for advanced Big Data Analytics innovations. Over 36 months, AgriBIT includes 20 months piloting at 3 locations, 12 months testing of collaboration services and delivers TRL-8 results. AgriBIT involves 5 solution providers (4 SMEs), 1 research centre and 2 farmers cooperatives with 11.250 members.

Keywords: gnss based applications,precision agriculture,integrated management farming,big data analytics
Dissecting microbiome and immune interactions in human intestinal (cancer) organoids (Organoid)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2020-10-31
Duration (months): 60.0
Total project cost (EUR): 3062438.0
EU funding (EUR): 3062438.0
Participants: 1
Project status: CLOSED

We pioneered the essential role of Wnt signals in adult stem cells, i.e. in intestinal crypts. We also found that loss of the APC gene activates the Wnt pathway and causes colorectal cancer (CRC). We then identified a Wnt target gene, Lgr5, which allowed us to define the crypt stem cells. In a previous ERC grant based on these findings, we identified novel Lgr5 stem cells in multiple organs, and defined in vitro culture conditions to grow epithelial organoids from single Lgr5 stem cells. Crucial in this was our identification of the Wnt agonistic R-spondins as the Lgr5 ligands. Cultured 'mini-guts' display all characteristics of normal gut, can be expanded for years, transplanted, and remain genetically stable. Here, I propose a reductionist, ‘mini-gut’-based approach to two exciting research fields that currently mostly focus at the organismal/patient level: Microbiome research leans on deep-sequencing of complex microbial communities in health and disease; and immune checkpoint research in cancer rests largely on clinical trials of checkpoint-blocking antibodies. While many insights exist into the gut microbiome and -immune system, the epithelium is often treated as a neutral player. ‘Mini-gut’ technology allows us to dissect interactions of the gut microbiome with healthy and diseased epithelium, and of Tumor-Infiltrating Lymphocytes (TILs) with CRC 'mini-guts' (tumoroids). To this end, we will describe/study 1) All immune receptors, -regulators and -effectors in the individual epithelial cell types. 2) 'Mini-guts' recombined with individual bacterial species, 3) CRC tumoroids recombined with their cultured TILs and subjected to immune checkpoint manipulation. Using advanced molecular and imaging technologies, we will chart the molecular mechanisms that underlie the interactions from the ‘epithelial perspective’. Ultimately, this program will provide molecular detail to the effects of the microbiome and immune system on our gut, in health and disease.

Keywords: intestine,microbiome,organoid,immune checkpoint
Total Airport Management (PJ04 TAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Ireland,Italy,Italy,Germany,Poland,Switzerland,Norway,Belgium,Croatia,Hungary,Lithuania,Slovakia,Sweden,Sweden,Norway,Belgium,France,France,France,France,Czechia,Netherlands,Denmark,United Kingdom
Call: Total Airport Management (H2020-SESAR-2015-2, 2015)
Start date: 2016-12-01
End date: 2019-12-31
Duration (months): 37.0
Total project cost (EUR): 19850987.16
EU funding (EUR): 8135653.53
Participants: 42
Project status: CLOSED

Why ? : Airport Operations Management in SESAR1 promoted enhanced situational awareness via the Airport Operations Plan (AOP) whilst reinforcing the collaborative decision making process through the Airport Operations Centre (APOC). Validation activities stressed the need to further develop the Performance Monitoring and Management services promoting the evolution from a reactive (“firefighting”) approach toward one of pro-active collaborative decision making. Impact : Includes the evolution toward a “performance-driven” airport through holistic monitoring of demand and capacity. Decision making will be based on more reliable information with enhanced decision impact assessment. Expected is an increase in the predictability, flexibility and efficiency of airport operations as well as increased resilience through shorter recovery to normal operations. Focus : PJ04 is articulated around two ‘SESAR Solutions’, emphasising all of the key airport processes. Integration of airports into the ATM network will be addressed through sharing information in a timely manner between the Network Operations Plan and the individual AOPs using SWIM technology. Who ?: PJ04 unites key European aviation industry partners combining the right expertise to address these challenges and to drive deployment of validated improvements. Benefits : As clients of airport services, airlines will benefit from enhanced operational efficiency. For passengers, benefits will be tangible. Information available will be of high quality and the more efficient use of airport resources will lead to enhanced service quality. EU Strategic : PJ04 will focus on a range of different airport complexity levels developing scalable and cost-effective solutions, optimising both the local benefits and those for the European network. Societal concerns will be addressed by ensuring that environmental mitigation measures and impact are included in the airport performance "trade off".
Supramolecular machineries with life-like mechanical functions (MechanoTubes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1752767.5
Participants: 2
Project status: SIGNED

Artificial molecular motors and switches have the potential to become a core part of nanotechnology. However, a wide gap in length scales still remains unaccounted for, between the operation of these molecules in solution, where their individual mechanical action is randomly dispersed in the Brownian storm, and on the other hand their action at the macroscopic level, e.g. in polymer networks and crystals. This proposal is about bridging this gap, by developing chemo-mechanical transduction strategies that will allow dynamic molecules to perform a range of unprecedented tasks, e.g. by generating strong directional forces at the nanoscale, and through shape-shifting microscopic formations. This project aims to harness the mechanically-purposeful motion of dynamic molecules as to generate measurable forces from the nanoscale, and ultimately establish operational principles for chemo-mechanical transduction in supramolecular systems. In my wholly synthetic approach, I draw inspiration from the operational principles of microtubules. I will incorporate molecular photo-switches into supramolecular tubes, and enable the controlled growth and disassembly of the tubes by using light as the energy input. Thus, I will: (i) Synthesize stiff supramolecular tubes that grow actively under continuous illumination, and disassemble with a power stroke as soon as illumination stops; (ii) Measure, and harvest the forces generated by the tubes to manipulate individual nanoparticles with a sense of directionality; and (iii) Encapsulate the tubes into water droplets and vesicles, to yield shape-shifting, and eventually rudimentary splitting models for cells. This project reaches beyond the state of the art in adaptive molecular nano-systems, by pioneering strategies to engineer and harness strain in supramolecular assemblies. It thus lays the foundations for machineries that are capable of manipulating matter at length scales that are also those at which the cytoskeleton operates.

Keywords: complex supramolecular systems,molecular motors and switches,light activated nano structures
Legislative Assessment for Safety Hazards of Fire and Innovations in Ro-ro ship Environment (LASH FIRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Germany,Cyprus,Belgium,Norway,Switzerland,Norway,Finland,Sweden,Sweden,Sweden,Sweden,Croatia,France,France,France,France,Netherlands,Portugal,Denmark,United Kingdom
Call: Marine Accident Response (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 13490527.24
EU funding (EUR): 12209148.33
Participants: 31
Project status: SIGNED

Ro-ro ships are an important component of the global transportation system, but an increasing trend of ro-ro ship fires in recent years call for improved fire protection. From comprehensive ship operators’ experience and by participation in ongoing work for the European Maritime Safety Agency and the International Maritime Organization (IMO), critical aspects of ro-ro ship fire safety have been identified to form the scope of the project LASH FIRE. It aims to provide a recognized technical basis for the revision of international IMO regulations, which greatly enhances fire prevention and ensures management of fires on ro-ro ships without recourse to external intervention. This is done by developing and demonstrating operational and design solutions which strengthen the fire protection of ro-ro ships in all stages of a fire and which address current and future challenges, including regulatory issues. Twenty specific challenges have been identified, which will be addressed by new solutions developed and demonstrated with regards to performance and ship integration feasibility by system suppliers, researchers, ship owners and shipyards. For the solutions to be considered for regulatory uptake, their impact on risk reduction and cost will be assessed and advisory groups with operators and flag states will be established. Thereby, the project is expected to significantly strengthen the independent fire protection of ro-ro ships and to reduce the frequency of ro-ro ship fires by 35% and the number of fatalities by 45%.
Viability assessment of collaborative and INNOvative business solutions in WorldWIDE markets (INNOWWIDE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Spain,Spain,Belgium,Finland,Finland,France,Netherlands,Portugal
Call: Partnering for viability assessments of innovative solutions for markets outside Europe (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-01-01
End date: 2021-07-31
Duration (months): 31.0
Total project cost (EUR): 8998325.0
EU funding (EUR): 8998325.0
Participants: 12
Project status: CLOSED

INNOWWIDE aims to bring European highly innovative SMEs to the forefront of international markets by prototyping and shaping a new and unique financial scheme (the “INNOWWIDE Call for proposals”) that will allow them to conduct Viability Assessment Projects (VAPs) in cooperation with local stakeholders, creating the conditions to increase the uptake of European innovative solutions in markets outside Europe. Two calls will be implemented with a total budget of 7,2M€, allowing to fund 120 VAPs (60k€/VAP), and targeting markets of developing countries, large emerging economies (Brazil, Russia, India, China, Mexico) and developed countries with the same allocation for each of these three country categories. The strength of this initiative lies in: (1) the experience of project partners concerning calls for proposals design and management, having 8 European funding agencies among them; (2) a SME-centric approach, to be implemented thanks to the extensive access and links to the European SMEs that project partners have; and (3) an ambitious stakeholder mobilisation plan with a strong focus on third country players thanks to partners international network of delegations (130 offices abroad in 45 countries). Project impact will be evaluated following a holistic, multilevel assessment approach covering European and international dimensions, done at VAP and at call level, and providing information from qualitative and quantitative points of view. This valuable information will be used to draw R&I policy conclusions, that will be shared with relevant policy bodies through the creation and operation of the “INNOWWIDE Policy Working Group”.

Keywords: policy making,impact evaluation
improved Method to Analyze composite materials suiTable for SLP structures with the aim of Reducing the Impact on the required eXperimental testing campaign (MATRIX)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Belgium,United Kingdom
Call: Innovative Composite Material Qualification Methodologies (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-12-31
Duration (months): 33.0
Total project cost (EUR): 1213250.0
EU funding (EUR): 973812.5
Participants: 3
Project status: CLOSED

MATRIX Project intend to support the economic matter of the airworthiness certification for composite SLP structures in FAR 25, developing an OPTIMIZED approach to analyse, test and validate a large numbers of innovative materials suitable for HECOLAG purpose. MATRIX output will be a SMART TOOL to streamline the standard Building Block Approach of composite material with a limited number of phisical tests at flat coupons level (L1), simple shape elements (L2) and detailed complex shape (L3).

Keywords: software,validation,correlation