Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
xBeam 3D Metal Printing (xBeam)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Ukraine
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Metal additive manufacturing segment shows impressive growth – in the last 5 years it grew by 43%. With this technology parts with unique shape complexity can be produced, opening new opportunities in design and providing dramatic reduction of material losses during production in comparison with conventional manufacturing. Moreover, using metal 3D printing in production, companies can significantly reduce lead times, accelerate the manufacturing process of the final product and reduce costs. Metal AM is especially used in aerospace, healthcare (medical, dental), automotive and machinery industries and R&D. Currently metal AM technology is not fully developed yet: it is not economically viable to produce parts with wall thickness 1-11 mm; moreover, existing AM technologies have numerous technical, economic, environmental and other problems. xBeam 3D Metal Printer (TRL 6), developed by Chervona Hvilya, is a new additive manufacturing technology which is based on direct deposition approach with electron beam as source of heating and using wire as feedstock material. This solution is covering the gap for 3D production of the parts with wall thickness 1-11 mm with both high productivity and high accuracy. The xBeam 3D Metal Printer is based on a unique technology, that assures high quality of built parts with little post-processing required, has the least cost of parts production among all existing metal AM printers, is completely safe and environmentally friendly. To ensure successful commercialization, in Phase 1 of SME Instrument, Chervona Hvilya intends to develop an elaborate feasibility study for xBeam commercialization that would include: a thorough market research, detailed user analysis, business model and a business plan with an extensive financial, pricing, and IPR strategy.

Keywords: metal am,3d printing,metal 3d printing,additive manufacturing,metal 3d printer,electron beam advanced manufacturing
Disaggregated Recursive Datacentre-in-a-Box (dReDBox)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Ireland,Israel,Ireland,Greece,Greece,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 6451500.0
EU funding (EUR): 6451500.0
Participants: 13
Project status: CLOSED

For all the superior features that low-power computing systems exhibit compared to conventional high-end server designs, there is a common design axiom that both technological trends are based on: the main-board and its hardware components form the baseline, monolithic building block that the rest of the hw/sw stack design builds upon. This proportionality of compute/memory/network/storage resources is fixed during design time and remains static throughout machine lifetime, with known ramifications in terms of low system resource utilization, costly upgrade cycles and degraded energy proportionality. dReDBox takes on the challenge of revolutionizing the low-power computing market by breaking once and for all server boundaries through materialization of the concept of disaggregation. Through a highly modular software-defined architecture for the next generation datacentre, dRedBox will specify/design/prototype modular blocks for SoC-based microservers, memory and accelerators, interconnected via a high-speed, low-latency opto-electronic system fabric, and that can be allocated in arbitrary sets, as driven by fit-for-purpose resource/power management software. These blocks will employ state-of-the-art low-power components and be amenable to be deployed in various integration form factors and target scenarios. dRedBox aims to deliver a full-fledged, vertically integrated datacentre-in-a-box prototype to showcase the superiority of disaggregation in terms of scalability, efficiency, reliability,performance and energy reduction. The prototype will be used as vehicle to demonstrate the value of dReDBox in 3 pilot use-cases stemming from three market segments: Security, Network Analytics and Telecom. With an industry-lead consortium comprising top academic experts too, dReDBox is in the best position to generate significant impact with its game-changing approach and contribute to Europe maintaining its leading innovation and market position in low-power advanced computing.

Keywords: datacentre disaggregation
Developing proprietary antibacterial phage-based particles against Campylobacter jejuni for food decontamination (AntiCamp)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Campylobacter jejuni is the most common foodborne contamination in Europe, affecting millions of people, and costing billions of Euros. Current procedures to treat this contamination do not offer sufficient solutions. Here I present a unique approach to eradicate the pathogen from food by utilizing a cost-effective and safe product that does not alter the taste, texture, or appearance of the food. This innovation involves a spray composed of proprietary phage-based particles, which inject antibacterial genes into C. jejuni, thus killing the pathogen. Current phage-based technologies for decontaminating food encounter a major hurdle, because large-scale phage production in the fastidious and pathogenic C. jejuni strain is highly challenging. However, a major advantage of my product is that it can be prepared in a safe and easy-to-grow Escherichia coli host rather than in C. jejuni. Another significant advantage is that the technology producing the phages enables rapid and efficient modifications to the phage-based particles. This platform thus allows easy isolation and manufacture of cocktails of phage-based particles able to target a variety of pathogenic serotypes of C. jejuni. Furthermore, the proprietary particles all have a common scaffold, thus simplifying the regulation, safety, and route of manufacture. I propose a clear commercialization activity with a highly qualified team that I recruited, from both the scientific and commercialization fields. Developing and commercializing this product will provide a proof-of-concept to demonstrate the strength of this approach and will thus pave the way for additional innovative materials based on this technology.

Keywords: foodborne disease,antimicrobials,spray,bacterial pathogens,escherichia coli
Design of innovative composite hybrid joints with electromagnetic compatibility (D-JOINTS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: Development of FEM fastener parametric/adaptable sizing tool including EMC impact, and manufacturing and EMC/LSP testing of demonstrators (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-05-01
End date: 2022-12-31
Duration (months): 32.0
Total project cost (EUR): 473541.25
EU funding (EUR): 473541.25
Participants: 3
Project status: CLOSED

D-JOINTS will explore new innovative composite-metal joints with enhanced lightning strike protection. The design of these joints will be achieved through a dedicated sizing tool. Key design parameters will be identified and coded in the tool. A material properties database will provide the needed material information for the design of each joint. Finally, the new joints will be integrated in a composite nose part. The manufactured demonstrators will be tested for lightning strike protection. The project objectives are: • Model the mechanical and electrical performance of reference joints • Improve the reference joints electromagnetic performance • Develop a sizing tool for dissimilar joints • Manufacture and test the CNP with the new dissimilar joints integrated in the structure

Keywords: dissimilar joints,composites joints,lightning strike protection,sizing
Nanoarrays: Self-assembled Hotspots for Enhanced Analyte Detection (N-SHEAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-08
End date: 2017-04-07
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

I aim to transform the way disease is currently detected through innovations in the design of nanoparticle-based biosensors that can be used to detect a number of diseases with global implications. The three most significant challenges facing biosensing are inaccuracy, insensitivity, and low-throughput detection. One technique that is capable of facing these challenges is Surface Enhanced Raman Scattering (SERS) which has demonstrated potential for extreme sensitivity (single molecule detection) and rapid, multiple-analyte detection within complex mixtures. Early stage diagnosis of disease requires the detection of trace amounts of analyte in multi-component biological samples (blood, urine, saliva). It is therefore particularly important for sensors to reach the single-molecule detection limit. Further, the ability to analyse biological samples without separation or other treatment steps is a crucial advantage of SERS. My approach involves the electrotuneable self-assembly of plasmonic nanoparticles at a liquid-liquid interface for SERS detection, overcoming the severe limitations of current sensors (sensitivity, specificity and speed). I will electrochemically control the positioning of the nanoparticles in a precise manner to maximise the Raman signal. Additionally I will utilise shaped nanoparticles, such as stars and ellipsoids, exploiting the enormous Raman enhancements observed at sharp metallic tips to push the sensitivity towards single-molecule detection limits. The ultrasensitive sensing capabilities will be extended to colorectal cancer diagnosis the third most prevalent cancer in the world which effects 1.4 million people per year. Due to the versatility of this system it can be adapted to any disease or virus where the related biomarker is known. This approach will allow me to build a new generation of sensors that will transform single-molecule SERS detection

Keywords: plasmonic nanoparticles,surface enhanced raman spectroscopy,electrovariable,sensor,liquid liquid,colorectal cancer,ultrasensitive detection,early diagnosis
Sequence-Enabled Single cEll Identification device (SENSEI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The dynamics of cell populations within tissues and organs is a hallmark of multi-cellular organisms. In many pathological states (e.g. cancer, diabetes etc) the functions and quantities of specific cell populations change. The ability to simultaneously and effectively monitor these functions and changes is essential for the study of these pathologies and the development of diagnostics and treatment. While single cell profiling is a multi billion dollar market, currently, unbiased and comprehensive classification of tissues into well-defined and functionally coherent cell subpopulations is impossible due to limitations in technology. Here we propose commercialize a technology we recently developed and published (Jaitin et al Science 2014) - Sequence-Enabled Single cEll identification (SENSEI) - based on massively parallel sequencing of RNA from single cells. Using broad sampling of single cell functional states from multi-cellular tissues we reconstruct biological functions in a bottom-up fashion, starting from the most basic building block – the cell. The potential benefits of this invention are blatantly evident. Since cells are the basic building blocks of multi cellular organisms accurate and dynamic description of cell states and functions is essential for both basic biological research and personalized medicine clinical applications. Our technique is immediately applicable in molecular biology labs, clinics or industry, requires no specific equipment beyond our developed consumables and can provide data on RNAs from hundreds of single cells at the cost of one standard average gene expression profile. Massively parallel single cell RNA sequencing is therefore emerging as a super high-resolution, robust and affordable approach for unbiased functional characterization of complex tissues and is likely going to dramatically change molecular research and have profound clinical applications.
Probing intracellular folding and dynamics of telomeric DNA structures with single-molecule FRET (G4invivo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Telomeres, the ends of linear eukaryotic chromosomes, are one of the most versatile “molecular machines” of life. They perform a vital role in several fundamental processes in biology, as maintenance of genome integrity and the regulation of cell growth. Human telomeric DNA consists of thousands of tandem repeats of guanine-rich sequences, terminating the chromosomes. Under physiological conditions, such guanine-rich repeats are capable of adopting four stranded structures, called G-quadruplex DNA. Considerable research has been dedicated to an understanding of functions of telomeres, and during the past decades, much progress has been made towards identifying the underlying processes for G-quadruplex DNA isolated in vitro. However, most of our knowledge of conformation and mechanistic understanding of the balance between the structure and function of telomeric DNA inside cells has remained very limited, largely due to a lack of suitable methods. An opportunity to bridge this gap is single-molecule fluorescence microscopy in combination with Förster resonance energy transfer (FRET), a powerful technique that allows distances, distance distributions, and dynamics of individual biological molecules to be measured even in complex and heterogeneous environments, as cellular milieu. The goal of this project is to employ such optical single-molecule techniques to perform a comprehensive biophysical analysis of the folding and dynamics of G-quadruplex DNA within live cells. This investigation will provide an idea of how accurately our current understanding of the folding and dynamics of G-quadruplex DNA in vitro describes the situation inside the living cell, and will, among other aspects, be crucial for understanding the biological functions of G-quadruplexes and in particular may stimulate the enhancement of the efficacy of the novel anticancer therapies, which use these structures as an active target for drug development.

Keywords: g quadruplex dna,telomeres,folding,dynamics,single molecule microscopy,forster resonance energy transfer fret,in vivo,molecular crowding
Innovative tools and solutions for governing the water-energy-food-ecosystems NEXUS under global change (GoNEXUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Austria,Germany,Spain,Switzerland,Belgium,Greece,Hungary,France,Netherlands,Netherlands,Canada,Senegal,Zimbabwe
Call: Understanding climate-water-energy-food nexus and streamlining water-related policies (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 5417013.75
EU funding (EUR): 4999813.75
Participants: 17
Project status: SIGNED

GoNEXUS aims to develop a framework for designing and assessing innovative solutions for an efficient and sustainable coordinated governance of the water-energy-food-ecosystems (WEFE) nexus. Solutions will combine policy changes and soft path options with technical and infrastructure measures for a more resilient future. To achieve this objective, the project will build a powerful model toolbox and creative participatory Nexus Dialogues. The model toolbox will include forefront global/continental and river basin models, innovatively establishing a functional link between them. At global and continental scales, the toolbox will include the individual WEFE element models CAPRI (food, agri-environment), LISFLOOD-EPIC and PCR-GLOBWB (water), PRIMES and PROMETHEUS (energy), GLOBIO (environment), and GEM-E3 (macroeconomics), some of them used in EU policies. River basin models will include nested strategic WEFE management models (including behavioral modelling) and hydrological simulation models to expand the analysis of resilience at basin scale, including impacts on ecosystems. Nexus Dialogues will co-design scenarios, models, and solutions for a joint governance of the WEFE nexus. The solutions will be evaluated using the model toolbox through a set of novel nexus indicators and criteria (based on relevant SDGs metrics) to assess trade-offs between water status, and food and energy security. GoNEXUS will be applied at global and EU levels and to six river basins representing different features and WEFE challenges in Europe (Danube, Como, Jucar, Tagus-Segura) and Africa (Zambezi, Senegal). The innovative combination of models and Nexus Dialogues will provide more accurate evaluations of future scenarios, enabling knowledge sharing and brokerage, and improving WEFE nexus management. The project will also contribute to align existing EU WEFE policies, promote the reduction of institutional fragmentation, and strengthen the EU role on water diplomacy.

Keywords: water energy food ecosystems nexus
Massively extended Modular Monitoring for Upper Stages (MaMMoTH-Up)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Sweden
Call: Independent access to space (H2020-COMPET-2014, 2014)
Start date: 2015-05-01
End date: 2018-08-31
Duration (months): 40.0
Total project cost (EUR): 2784014.0
EU funding (EUR): 2784014.0
Participants: 5
Project status: CLOSED

Today, the amount of telemetry data from the sensors in the upper stages of a launch vehicle is very restricted, due to limited on-board-computing capacities combined with limited data bandwidth to ground. As a result, no detailed information about the various phases of the flight is available. Massively extended Modular Monitoring for Upper Stages (MaMMoTH-Up) will improve the amount of monitored data by a factor of more than 2500 by integrating four key objectives, which are 1. a self-configuring monitoring framework that will selectively observe, pre-process, and compress sensor data, 2. Components off the Shelf (COTS) that provide improved computing performance on a launcher, 3. design solutions guaranteeing the required levels of dependability, even when using relatively unreliable COTS components, and 4. a tight coupling with advanced dependability analysis. Achieving these 4 goals is scientifically and practically highly relevant. A demonstrator at TRL 6 will show the advantages of the new monitoring infrastructure and a virtual prototype proves the advanced dependability enhancements. Thus, MaMMoTH-Up will provide a framework and a proof-of-concept for next-generation avionics solutions for a launcher based on COTS. Moreover, the work plan provides the path to realization, potentially including a demo-flight at the end of the project. The proposed technology is complementary with on-going launcher developments. The usage of COTS will represent a direct advantage over competitors; this will decrease time-to-market and decrease the European dependence on external suppliers. MaMMoTH-Up directly addresses the call COMPET-2-2014 by providing an innovative avionics solution for safer and more reliable launch operations for conventional launching systems. The solution developed within MaMMoTH-Up strengthens competitiveness and cost-efficiency having an immediate commercial potential.

Keywords: monitoring,components off the shelf,self testing