Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A platform to boost robotic innovation by enabling fast development cycles, reduced cost and low barrier to entry. (LUOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our vision is to make robotic product development as accessible as online publishing is today. Our aim is to power the social and personal robotic revolution. Today robotic companies have vertical models, they source, conceive, build, mass produce and distribute their own robots. This is a high cost and high risk endeavour that put the brakes on innovation and on the exploration of new markets. To reach its full potential, robotic must transition to a horizontal industry where companies become specialized in one layer of the robotic value chain. We have conceived a disruptive modular robotic architecture, called Luos, that makes robotic product development much simpler. It takes the form of a set of embedded code libraries, hardware interfaces and control software that enables to bring robots to market in months rather than years. It is the result of years of expertise with patented technologies. Our envisioned business model is one of a platform. Our basic tools are available in open source to create win-win situations and enable fast market uptake. Robotic companies would pay for premium features recurrently and in proportion with their revenues. The expected impact is to enable more companies, and primarily technological startups, to develop products involving robotic technologies. This revolution will reach and disrupt a wide range of new markets previously unattainable with conventional development methods. As a result, more innovative products will be created which will lead to an improvement of living standards in our societies. To achieve this potential, it is crucial to build on a first mover advantage to gain time and market shares over competitors. Our objective for this proposal is to bring our technology to TRL6 level. We target to develop three robotic platforms with three companies in three distinct markets. We will pursue market research and business analysis to identify a first niche market to demonstrate our technology and build reputation.

Keywords: modular robotics,robotic engine,open source
Microbial community response to the invasion of a non-endemic fungal bio-inoculant in soil (ALIENinSoil)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Fungi and bacteria are utilised for the production of microbial-based fertilisers and pesticides worldwide. These bioinoculants have a huge potential in agriculture because they can help to increase crop yields and quality and allow a reduction in the application of chemicals. While the effectiveness of bio-inoculants as bio fertilisers or biopesticides is widely tested for crop yield and pathogens control, little is known about the effect of bioinoculants on microbial assemblages in the non-rhizospheric soil of agroecosystems. A sudden artificial introduction of a fungal species in soil could create a substantial impact on the biodiversity of endemic microbial species and local community functions, as well as lead to changes in the food webs and nutrients availability. ALIENinSoil will, therefore, assess the impact of a fungal inoculum, the globally-used biofertiliser Trichoderma afroharzianum T22, on microbial assemblages of a model soil system. The project will apply an innovative rapid metagenomic approach based on long-read Oxford Nanopore Technology to assess the effects of the fungal inoculum on soil microbial communities and functions in a laboratory-based microcosms experiment. Thus, this project will use innovative and cutting-edge techniques to understand 1) to what extent the native microbial community richness and relative abundance is influenced by a competitive fungal strain introduced to soil; 2) whether or not the keystone microbial taxa are resilient to the disturbance by the introduced fungus 3) how far the bioinoculant impacts the functions of soil microorganisms. With this action, I want to acquire new in-depth knowledge necessary to stimulate innovation in the field of soil bioinoculants and agriculture by way of competitive technology transfer. Oxford Nanopore sequencing has great potential to be used for real-time diagnostics in agricultural surveys and the development of indicators for monitoring soil biodiversity and functionality.

Keywords: biofertilisers,microbial community,biodiversity,function,soil metagenome,long reads
Restoration of tumor suppressor function by induction of translational read-through of premature termination codons - a strategy for improved cancer therapy (TRANSREAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2480889.0
EU funding (EUR): 2480889.0
Participants: 1
Project status: CLOSED

Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors. A significant fraction of the mutations in these genes are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional proteins. We will identify and characterize novel molecules that can induce translational read-through of premature termination codons in nonsense mutant TP53 and expression of full length p53 protein. Hits will be tested for their effect on nonsense mutant RB1, PTEN and APC. We will also elucidate the molecular mechanism of action of the identified compounds by CETSA and other techniques. Moreover, we will test hit compounds on primary tumor cells from patients ex vivo, and generate mouse knock-in tumor models with nonsense mutant tumor suppressor genes for further characterization of hits. We will take the most promising hits through preclinical development towards clinical trials. Our aim is to develop novel and efficient targeted therapy for tumors with nonsense mutations in the TP53, RB1, PTEN and/or APC tumor suppressor genes.

Keywords: tumor suppressor genes,tp53,nonsense mutations,translational read through,cancer therapy
Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery (CARTHAGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Finland,Poland,Romania,Sweden,Switzerland,Netherlands,Netherlands,Netherlands,Denmark,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 4002427.08
EU funding (EUR): 4002427.08
Participants: 12
Project status: SIGNED

Chronic low back pain due to intervertebral disc (IVD) degeneration and osteoarthritis (OA) worldwide impact human health and well-being due to pain and impaired mobility. Non-viral gene therapy has great promise as safe and precision treatment to restore IVD and joint tissue health. However, the lack of accessibility of the affected cartilaginous tissues to drugs has inhibited progress in this field. We will finally fulfil the promise of non-viral gene therapy in these diseases. We will do this through educating 15 young researchers in 10 different countries in physics, quality by design (QbD), nucleic acid chemistry, nanomedicine, cartilage and IVD biology, ethics, entrepreneurship and academic transferable skills. This highly multidisciplinary team will exploit the potential of gene therapy in IVD and joint disease by taking a multi-faceted approach towards the delivery and activity of oligonucleotides and encoding nucleic acids (NA). Cell and tissue delivery will be achieved by nucleic acid modification, innovative nanocarriers and tissue targeting, supported by QbD. Ultrasound will for the first time be used to enhance NA tissue penetration and transfection, and to trigger local release from systemically administered endogenous albumin-NA conjugates. Imaging tools will be developed to monitor in vivo regeneration, saving numerous animal lives in the future. Moreover, we will set up an educational framework for embedding biomedical ethics in biomedical research and valorisation, providing a firm and sustainable basis for Responsible Research and Innovation for future biomedical science and technology. Participation of a patient organisation and a scientific organisation experienced in the dialogue with society, will ensure researchers at ease in communicating with different audiences. Hence CARTHAGO will deliver the agile scientists freely moving between sectors and firmly anchored in society, required to take science and innovation to the next level in Europe.

Keywords: osteoarthritis,intervertebral disc degeneration,nanomedicine
Quilted Stratum Processes (QSP) for low cost and eco thermoplastic manufacturing of complex composite parts (SHERLOC QSP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Quilted Stratum Processes (QSP) for low cost and eco thermoplastic manufacturing of complex composite parts (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 480001.81
EU funding (EUR): 400000.0
Participants: 2
Project status: CLOSED

SHERLOC QSP aims at designing and manufacturing a batch of composite panels incorporating thermoplastic composite window frames (for regional airplane) made following an innovative manufacturing process, called QSP that allows lighter mass with cheaper cost and shorter manufacturing cycle time of parts than existing processes. The project will contribute to the reduction of the environmental impact: - Weight saving of parts manufactured by the use of net shape and multi-thickness preforms with the right material at the right place, will contribute to the reduction of CO2 emissions, - Significant reduction of waste material by exploiting the composite at the maximum of its possibilities. It will help the industrials to be more efficient and performant: the above points automatically result in cheaper cost of the parts (less expensive material used by a better exploitation of materials, less composite waste implies therefore a better valorization of costly noble materials). QSP, developed for high rate production of automotive parts (one composite part/minute), will finally contribute effectively to reach the necessary productivity in the near future to meet the ramp up production of planes and aircraft components. The very short deadline imposed by the call (18 months) has guided the decision to build a small consortium with only 2 partners, Cetim (a French technological research center involved in composites since the 80’s) and Compose Tooling (one of the major French tool makers). These 2 partners are used to work together and are very agile to solve problems in a short time. Together, they have the complete skill to answer all the technical needs expressed in the call (design, manufacturing of parts and assemblies, material testing, NDT control, cost assessment, repairing). Cetim and Compose were involved in the implementation of QSP for automotive parts and have a clear strategy with other industrial partners to transfer this technology to aeronautic sector.

Keywords: composite,quilted stratum processes qsp,thermoplastic
Large Scale Silicon Photonics Matrix for Low Power and Low Cost Data Centers (L3MATRIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Spain,Austria,Israel,Germany,Greece,Switzerland,Netherlands,United Kingdom
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2019-05-31
Duration (months): 42.0
Total project cost (EUR): 3836186.25
EU funding (EUR): 3123966.25
Participants: 9
Project status: CLOSED

Cloud storage and computing, big data analytics and social media are driving the need for higher bandwidth communications in data centres (DCs). Concurrently, disaggregation and virtualization trends in the DC are forcing the traffic to be between servers and storage elements in the east-west direction. These changes require massive switching capabilities from the discrete switch elements. However, the technology is rapidly reaching a limit. The result is a multi-layered DC topology with high power consumption and long latency. The L3MATRIX project provides novel technological innovations in the fields of silicon photonics (SiP) and 3D device integration. The project will develop a novel SiP matrix with a scale larger than any similar device with more than 100 modulators on a single chip and will integrate embedded laser sources with a logic chip thus breaking the limitations on the bandwidth-distance product. Use of embedded laser sources and integration with a full logic CMOS chip are innovative steps that will have a profound effect on the European market as these technologies will make a noticeable change in the power consumption, performance and cost of DCs. A novel approach will be used with embedded III-V sources on the SOI substrate which will eliminate the need to use an external light source for the modulators. L3MATRIX provides a new method of building switching elements that are both high radix and have an extended bandwidth of 25 Gb/s in single mode fibres and waveguides with low latency. The power consumption of DC networks built with these devices is 10-fold lower compared to the conventional technology. The outcome of this approach is that large networks, in the Pb/s scale can be built as a single stage, non-blocking network. The single mode nature of the SiP chip allows scaling the network to the 2000 m range required in modern DCs.

Keywords: hybrid cmos integration,data centre networks,iii v on soi
Building trust in nuclear waste management through participatory quantitative story telling (ENTRUST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2020-07-31
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

This research action is coordinated by AMPHOS21 Consulting S.L. (AMPHOS21) located in Barcelona, Spain, in collaboration with Stanford University's Center for International Security and Cooperation (CISAC). It is motivated by the general question of how to manage in the long term the growing stocks of spent nuclear fuel (SNF) and high-level radioactive waste (HLW) produced at commercial power plants in a context of uncertain transitions and persisting societal concerns over nuclear energy technologies. A new approach will be developed that merges three academically separated but intellectually related and complementary research strands in the holistic study of nuclear energy systems: Integrated Assessment, Nuclear Waste Management, and Science for Governance. Our aims are i) to combine the research perspectives of the Partners to define a theory for the holistic study of nuclear waste management (NWM) systems aimed at building public trust; ii) to develop an analytical framework as a methodological body for the participatory quantitative story telling of NWM strategies and policies and test it as part of CISAC’s "Reset of U.S. Nuclear Waste Management Policy" initiative; and iii) to complete an integrated analysis of NWM policies in the United States (US) and selected European Union (EU) countries, and subsequently develop a strategy at EU level.

Keywords: nuclear waste management,radioactive waste,energy systems,integrated assessment,modeling,multi criteria analysis,narrative analysis,science for governance,policy support,public trust
Continuous Diaphragm Monitoring of mechanically ventilated patients (DiaMon)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Norway
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2020-03-31
Duration (months): 32.0
Total project cost (EUR): 2988500.0
EU funding (EUR): 2988500.0
Participants: 1
Project status: CLOSED

Respinor aims to seize a major market opportunity through the clinical validation, technology maturation and commercialization of a unique ultrasound technology for Diaphragm Monitoring – DiaMon. DiaMon is a non-invasive ultrasound device that is designed to provide precise, continuous and real-time information of diaphragm function. The diaphragm is the main muscle involved in breathing. Treatment with Mechanical Ventilation (MV) results in high costs for healthcare systems. The incremental cost of MV is estimated to be €1,500 per patient per day. With an estimated 1.35 million MV patients in the EU per year for an average of 4-5 days, this represents an expenditure of at least €8.1 billion annually. Therefore, it is highly important both clinically and economically to bring patients off MV and back to normal, spontaneous breathing as quickly as possible. There is currently a severe lack of accurate and cost-effective solutions to support the MV process. Respinor aims to fill this gap, by demonstrating and commercializing a cost-effective and user friendly ultrasound device, being the only effective non-invasive alternative to invasive catheter based solutions. Under Eurostars and Horizon 2020 SME Phase 1 grants, Respinor has developed a first version of DiaMon and initiated clinical studies. Preliminary results are very promising. The overall objective of H2020 Phase 2 is to: 1. Demonstrate in large clinical trials (700 patients) that DiaMon can reduce MV failure compared with standard of care and 2. Further develop DiaMon into a commercial product with high usability and acceptance in the ICU setting. The accomplishment of the proposed project objectives will bring major benefits to Respinor with a forecast significant cumulated turnover by 2025 in the ICU MV market segment. The demonstration of the benefits of DiaMon in the weaving process will foster the entrance in the large respiratory market.

Keywords: respiratory disorders,mechanical ventilation,intensive care,ultrasound,diagnostic equipment
Evolution of Direct Reciprocity in Complex Environments (E-DIRECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1441500.0
EU funding (EUR): 1441500.0
Participants: 1
Project status: SIGNED

Direct reciprocity is a fundamental mechanism for cooperation among non-kin. It is based on the idea that individuals are more cooperative when they interact in stable groups in which retaliation is possible. To model the evolution of reciprocity, researchers have used the framework of repeated games. Traditionally, these models rest on two assumptions. First, players are symmetric: they coincide in their strategic options, in their incentives to cooperate, and how they discount future payoffs. Second, the players' environment is fixed: players face the same game, with the same payoffs, in every round. Both assumptions are crucial, as they promote conditionally cooperative strategies like Tit-for-Tat. Yet in most natural applications, individuals are heterogeneous, and the games they play change over time. To address these two critical model limitations, we need to expand the theory of reciprocity. We focus on the following objectives: 1) Develop a theory of reciprocity in heterogeneous groups. Based on mathematical models and simulations, we study how different dimensions of heterogeneity affect the evolution of reciprocity. 2) Develop a theory of reciprocity in changing environments. Here, we explore the evolution of cooperation when the players' environment (and hence their feasible payoffs and strategies) can change from one round to the next. We ask which environmental feedback is most favorable to cooperation. 3) Explore the dynamics of asymmetric games with changing environments. Here, we analyze the intricacies that arise when both previous sources of complexity are present. 4) Verify the theory using behavioral experiments with human subjects. The success of the project will establish a novel framework and new tools to study the evolution of strategic behavior in non-constant environments. It will significantly enhance our ability to predict when reciprocity emerges under natural conditions.

Keywords: evolutionary game theory,cooperation,reciprocity,evolutionary dynamics