Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding host cellular systems that drive an endosymbiotic interaction (CELL-in-CELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 2602483.0
EU funding (EUR): 2397385.76
Participants: 3
Project status: SIGNED

Endosymbiosis is a key phenomenon that has played a critical role in shaping biological diversity, driving gene transfer and generating cellular complexity. During the process of endosymbiosis, one cell is integrated within another to become a critical component of the recipient, changing its characteristics and allowing it to chart a distinct evolutionary trajectory. Endosymbiosis was fundamentally important to the origin and evolution of eukaryotic cellular complexity, because an endosymbiotic event roots the diversification of all known eukaryotes and endosymbiosis has continually driven the diversification of huge sections of the eukaryotic tree of life. Little is known about how nascent endosymbioses are established or how they go on to form novel cellular compartments known as endosymbiotic organelles. Paramecium bursaria is a single celled protist that harbours multiple green algae within to form a phototrophic endosymbiosis. This relationship is nascent as the partners can be separated, grown separately, and the endosymbiosis reinitiated. This project will identify, for the first time, the gene functions that enable one cell to incubate another within to form a stable endosymbiotic interaction. To identify and explore which host genes control endosymbiosis in P. bursaria we have developed RNAi silencing technology. In the proposed project we will conduct genome sequencing, followed by a large-scale RNAi knockdown screening experiment, to identify host genes that when silenced perturb the endosymbiont population. Having identified candidate genes, we will investigate the localisation and function of the host encoded proteins. This project will significantly change our current understanding of the evolutionary phenomenon of endosymbiosis by identifying the cellular adaptations that drive these interactions, advancing our understanding of how these important moments in evolution occur and how core cellular systems can diversify in function.

Keywords: endosymbiosis,cell evolution,rna interference,organelle,algae
Generating new sOlutions 2 and from Space through effective local start-up HUBs (Go2Space-HUBs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Estonia,Spain,Poland,Belgium,Bulgaria,Portugal
Call: Space hubs (support to start-ups) (H2020-SPACE-2019, 2019)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 1106626.25
EU funding (EUR): 1106626.25
Participants: 7
Project status: CLOSED

The objective of the Go2Space-HUBs proposal is to secure the creation and up-scaling of European businesses, offering technology and services in and from the space-sector, ensuring value creation and innovation through cross-fertilization, training and locally owned and driven networks and initiatives that connect effectively with existing EU initiatives. This will be achieved through the creation of 3 new Space Hubs in Madrid, Tallinn & Coimbra strengthening local entrepreneurship/business ecosystems & networks. The 6 consortia partners represent key players in the local and regional start-up ecosystem. The 3 new HUBs have extensive experience in providing support to start-ups and will be supported by entities that are: experts on investor readiness & access to finance services; technology transfer, in addition to an aerospace cluster representing SMEs from all the relevant space-segments. The project responds effectively to the work programme by including a range of new local initiatives for entrepreneurs, start-ups, scale-ups and SMEs, building bridges to EU activities, and designed to secure the creation of new start-ups & to help start-ups and scale-ups grow. The uniqueness of GO2Space HUBs relies upon a process through 4 phases: AWARENESS, SUPPORT, SCALE AND SUSTAINABILITY. Go2Space HUBs includes: Incubation of 20 entrepreneurs/early stage start-ups; acceleration of 20 established start-ups/scale-up; Demo-Days to present their solutions to Investors and partners; Innovations Days; B2B events to facilitate spinning-in/-out; Organization of Hackathons; Joint-applications to the Copernicus incubator; An “Up-scaling engine” to help a range of local scale-ups and SMEs secure more efficient growth, introduction to existing space recourses; identifications of barriers to investments in space; Targeted training on access to private and public finance & Final Investment & Partnering event with participants from all the 3 HUBs.

Keywords: technology transfer,cross fertilization,scale up
Climate Resilient Cities and Infrastructures (RESIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Germany,Slovakia,Poland,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Disaster Resilience & Climate Change topic 1: Science and innovation for adaptation to climate change: from assessing costs, risks and opportunities to demonstration of options and practices (H2020-DRS-2014, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 7466004.5
EU funding (EUR): 7466004.5
Participants: 17
Project status: CLOSED

With most of its population and capital goods concentrated in urban areas, cities are key to the European economy. One of the major challenges cities face are more frequent extreme weather events due to climate change.The current diversity of approaches and methods available for cities developing an adaptation strategy limits the comparability between cities of vulnerabilities, adaptation options, infrastructures, etc., and, as a result, the resilience capability. The lack of standardized information to prioritize and select appropriate adaptation options restricts the exchange of experiences between cities. The objective of RESIN is to provide standardised methodologies for vulnerability assessments, performance evaluations of adaptation measures, and for decision support tools supporting the development of robust adaptation strategies tailored to the city. To this end, RESIN aims to create a common unifying framework that allows comparing strategies, results and identification of best practices by • Creating an urban typology that characterises European cities based on different socio-economic and biophysical variables • Delivering standardised methods for assessing climate change impacts, vulnerabilities, and risks; providing an inventory of adaptation measures and developing standardised methods to assess the performance of such adaptation measures • Collaborating closely with 4 ‘case cities’ for practical applicability and reproducibility, and with European Standardisation organisations to ensure a systematic (standardised) implementation • Integrating findings in a coherent framework for the decision making process, with associated methods, tools and datasets The consortium consists of 17 partners from 8 different European countries, experienced in urban resilience and climate change, and combining theory (knowledge institutes/universities) with practice (cities, consultancies, network organisation, standardisation institute).

Keywords: climate change,adaptation options and adaptation strategies,vulnerability,cities,critical infrastructure,decision support system,standardisation
Renewable materials and healthy environments research and innovation centre of excellence (InnoRenew CoE) (InnoRenew CoE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Slovenia,Slovenia,Slovenia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 495625.0
EU funding (EUR): 495625.0
Participants: 10
Project status: CLOSED

With excellence in research, innovation, and application into economy and society, the new Centre of Excellence, Renewable materials and healthy environments research and innovation centre of excellence (InnoRenew CoE) will improve sustainable building practices by combining the existing concepts with the Restorative Environmental Design (RED) paradigm, which combines sustainable building practices with biophilic design. This will increase the competitive advantages of the affiliated renewable resource-based construction industry, and create innovation and market pull for RED-based materials and products (holistic living environment). Consequently, innovation and market pull for material recovery and higher added value renewable resource based and energy carriers will be initiated. Research and development activities will seek the optimal intersection of performance and sustainability, including economic, environmental and societal indicators. With support and guidance from the advanced partner, Fraunhofer WKI, scientific research and development activities will be transferred profitably and efficiently to the industry and through them to society in the form of innovative new products and processes.

Keywords: renewable resources,renewable materials,building materials,building systems,built environment,human well being,innovation,living laboratories,ergonomic design
Trade, Trauma and Tradition: Extractive industries, cultural genocide and Indigenous resistence in the 1900s and today (TTTRAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-01
End date: 2024-07-16
Duration (months): 36.0
Total project cost (EUR): 294886.08
EU funding (EUR): 294886.08
Participants: 1
Project status: SIGNED

This project studies Amazonian indigenous peoples’ search for justice and protection from the devastating impacts of European funded extractive industry activities during the rubber boom in the early 1900s and today. The approach is multidisciplinary (MD) crossing genocide, human rights, anthropology, history, social psychololgy and digital media studies (DH). It will produce a groundbreaking feature length documentary investigating the genocidal regime of the British registered Peruvian Amazon Company; the resurgence of the peoples of the region from less than 300 survivors of the rubber boom; and, their search for reconciliation and prevention of a similar business-related genocide today.The documentary will be informed by innovative research on the role and potential of European and its Member States law and policy to prevent business related genocide in Amazonia. The project empowers indigenous peoples through participatory video and digital storytelling (DST) to tell their history in their own way and words) [DST productions are usually 1-5 minute videos which can be made on mobile phones] It’s a story of genocide, resilience, reconciliation and the role of their own laws and cultural practices in their revival as peoples.In little over 30 years the PACs operations in the Predio Putumayo, a place the size of Belgium, led to the death of over 30,000 indigenous people [some estimates go as high as 100,000 dead]. Less than 300 survived, A hundred years on, from the end of the rubber boom, indigenous peoples in the Amazon are are again facing severe business-related threats to their lives, lands and culture. This time the threats come mainly from oil, mining and the agri-business sector.This project is timely asking what the European Union can do to help prevent business- related ecocide (massive environmental destruction) and cultural genocide (destruction of indigenous peoples’ cultural integrity) today.

Keywords: extractive industries,indigenous peoples,genocide,ecocide
The role of megafauna in biogeochemical cycles and greenhouse gas fluxes: implications for climate and ecosystems throughout history (MegaBiCycle)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Megafauna play an important role in carbon cycling and fluxes of greenhouse gases. Through consumption and excretion of biomass, megafauna accelerate nutrient cycling, increasing plant productivity and influencing soil greenhouse gas fluxes. Megafauna also emit methane when digesting plants through fermentation. Consequently, megafauna can have wide-ranging impacts on ecosystem functioning and climate. However, methodological limitations in dynamic global vegetation models and research gaps in megafauna ecology hamper our ability to assess these impacts. These gaps include: (i) a limited representation of megafauna in vegetation models; (ii) a lack of large-scale, long-term studies detailing the influence of megafauna on nutrient cycling and greenhouse gas fluxes; (iii) insufficient knowledge on how the current loss and introduction of megafauna is affecting ecosystems and their services. This project will address these research gaps by first developing a new classification of the effects of megafauna across biomes for present and late Quaternary species. This classification will then be used to simulate megafauna-ecosystem interactions in a dynamic global vegetation model (ORCHIDEE). This new tool will allow to test hypothesis on the effect of past and present changes in megafauna populations on a) plant primary productivity and carbon cycling and b) methane and nitrous oxide fluxes. The proposed project has the potential to greatly advance our understanding of the connection between climate, biosphere, and megafauna. The results will have implication for climate policy and conservation. Strong contributions to climate modelling, ecology, and paleoecology are to be expected. The candidate’s experience in megafauna-ecosystem interactions and ecological modelling, coupled with the host's expertise in climate and vegetation model will provide new insights into the role of megafauna in past, present, and near future global changes in climate and ecosystems.

Keywords: vegetation modelling,dgvm,plant animal interactions,megaherbivores,large herbivores,mass,extinctions,nutrient cycling,late pleistocene,late quaternary,carbon cycle,methane
Are HPV vaccines ‘evolution-proof’? Multilevel evolutionary ecology of human oncoviruses (EVOLPROOF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1987492.96
EU funding (EUR): 1485731.71
Participants: 2
Project status: CLOSED

There is a threat that evolutionary responses can render vaccines ineffective, as illustrated by the emergence of the increasingly virulent Marek Disease Virus strains in poultry following vaccination campaigns. Assessing the ‘evolution-proof’ nature of vaccines targeting human viruses is challenging because it requires an understanding of the epidemiology, the within-host ecology and the evolutionary potential of the virus. To date, most investigations into the spread of vaccine-resistant strains are theoretical and are rarely constrained by data. We propose a novel alliance between evolutionary ecology and clinical research to assess the risk of vaccines selecting for resistant or virulent strains. Human papillomaviruses (HPV) and their vaccines provide an ideal study system. However, the scope of the project is wider and encompasses other DNA viruses. The project is divided into three parts. In Part A, we will decipher HPV within-host dynamics in genital infections. By combining mathematical modelling and longitudinal patient data, we will be able to parameterise within-host models and compare them. In Part B, we will jointly analyse host, virus and genital microbiota diversity using a community ecology approach to understand the infectious process. These results will be integrated into evolutionary epidemiology models allowing for diverse infections. In Part C, we will estimate virus substitution rates and use the results from Parts 1 and 2 to develop a multilevel analysis of HPV evolution in response to vaccination. We will also tackle more general questions related to the evolution of the virulence of human oncoviruses. A major asset of the project is the collection of clinical data in order to address a major public health issue using ideas and methods from evolutionary ecology. This will set a new agenda for the study of human viral infections and establish a perennial leading research group in Europe.

Keywords: virulence,vaccination,human papillomavirus,cancer
Commercial validation of iPROCELL: a novel modular assembly practice (iPROCELL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany,Germany
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-06-01
End date: 2020-02-29
Duration (months): 33.0
Total project cost (EUR): 1741604.5
EU funding (EUR): 1219123.15
Participants: 3
Project status: CLOSED

iPROCELL has been developed to meet an identified need to improve for economies of scale within the electric vehicle (EV) production market. The new market we are developing is a world first, sitting between manual manufacturing and full production line assembly. Neither existing solutions are cost effective with the current levels of EVs being produced. Our solution is a fully automated final assembly cell, with 3 autonomous robots situated around a central industry build location. Our main innovation is our method of assembly, the 3 robots work symbiotically to assemble modules into finished products. This design provides a footprint that is 12 times smaller than traditional production lines. We have incorporated our state of the art gripper technology for fully adaptable programmable robotic heads that can accommodate 12 different design options, allowing assembly of small batches in a cost effective manner. Our modular format allows fully flexible manufacturing, appealing to the increasing customer demand for evermore customised products. The high flexibility required to accommodate small series customised products alongside the commercial need to run a cost effective practice is challenging a number of manufacturing industries. When demonstrating the prototype at the Hannover Messe 2015, we received significant interest from a number of industries beyond the EV market including furniture and domestic appliances construction opening further opportunities for us to capitalise on. Forecasted to have a global worth of €184 bn by 2020, the automation solutions industry is growing. During this Phase 2 project we intend to finalised our existing technology ahead of market launch, in order to achieve this we need to: refine the subsystems and software; develop gripper and sensor systems; obtain the relevant standards; build a demonstrator unit and trial in a commercial setting. This will enable us to launch iPROCELL to market in 2020.

Keywords: advanced manufacturing,e mobility,production,modularity,assembly,fully automated,robotics,economies of scale
FULLY AUTOMATED ROBOTIC SYSTEM for ALL PROCESS STEPS of the HAIR TRANSPLANTATION SURGERY PROCEDURES (FUE-Robotic System) (FUE - Robotic System)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Türkiye
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FULLY AUTOMATED ROBOTIC SYSTEM for ALL PROCESS STEPS of the HAIR TRANSPLANTATION SURGERY PROCEDURES (FUE-Robotic System) We introduce a groundbreaking innovation which is a patented Robotic System into Hair Treatment Field. Hair transplantation is used to treat hair loss, a condition that affects more than 50 million men and 30 million women in the world. The total market size for hair transplantation surgery has increased 28% since 2012, or from 1.9 billion EURO (€) in 2012 to 2.5 billion EURO (€) in 2015*. At almost 1.050.000 Hair Transplantation Procedures are performed annually worldwide*. It is a fantastic opportunity to reach an Untapped Market. The submitted proposal relates to a method and apparatus for hair transplantation and in particular a method and apparatus for FUE Method Hair Transplantation which utilizes SCS (Spherical Coordinate System) Mechanism, Gripper and 3D Data Processing Software. Our Patented FUE Robotics System is the First and Only Robotic Hair Transplant System to safely introduce completing the whole Process Steps of the FUE Hair Restoration Surgery Procedure without any Human Error Factor. Furthermore, The FUE Robotics System can reduce up to 85-90 % of surgery time period when compared to manual FUE techniques and currently being developed other Robotic Systems in the market in the USA. It provides The Best Quality - Quantity - Price Ratio of all available hair transplantation methods. Other hair transplantation techniques cannot offer these highly sophisticated technological advancements. *Source; The International Society of Hair Restoration Surgery (ISHRS), 2015 Practice Census. This Proposal was submitted for another Work Programme Topic on the previous Cut-Off Day and ESR Total Score: 13,78 but it was not provided because of the Limited Budget in SMEInst-06-2016-2017: Accelerating Market Introduction of ICT Solutions for Health, Well-Being and Ageing Well. Seal of Excellence: Annex Page:20 .

Keywords: hair transplantation,fue method,surgery,robotic hair transplantation,robotic surgery,robotic,aesthetic surgery,plastic,reconstructive and aesthetic surgery