Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Validation of Open organ-on-chip Technology for End user applications (open-TOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Organ-on-Chips, and more general microphysiological systems, are believed to revolutionize the way we develop drugs or select personalized therapies. Recapitulating human response both from healthy and diseased individuals potentially even enables ‘clinical trials in-a-dish’. While research in this field is thriving and commercial start-ups have been founded, adoption from end users is staying behind due to a number of reasons: i) lack of standardization making chips not compatible with each other, ii) lack of automation which limits the throughput and user-friendliness of the systems and iii) lack of support for sensor integration. The Twente Organ-on-Chip Platform (TOP) is designed to overcome these hurdles and has been developed for internal use during the ERC project VESCEL. During interaction with other researchers and companies within the Organ-on-Chip field they expressed their interest in a more standardized, automated platform that also supports sensor integration. Since it would require a number of steps for them to be able to use the platform in their existing environment we here suggest the ‘open-TOP’ ERC Proof of Concept project where we aim to commercialize the application of the Twente Organ-on-Chip Platform (TOP) and facilitate end users to use TOP in real world contexts. To reach this objective we need to develop a robust interconnect, validate and identify difficulties in making a third party chip TOP-compatible, validate the use of TOP for a biological experiment and finally determine the commercialization strategy for TOP. We believe TOP can help more end users to adopt Organ-on-Chip as a technology in their lab because in contrast to current setups, the open technology of TOP supports chips from third parties are inter compatible, multiplexable and controlled automatically. If ‘open-TOP’ is granted, TOP will be the standardized Organ-on-Chip infrastructure allowing users to stop worrying about control systems and only focus on chips and biology.

Keywords: organ on chip,standardization,platform technology,automation
New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinases (NEW DEAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Spain,Belgium,Belgium,France,France,France,United Kingdom
Call: Nanoformulation of biologicals (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-01-01
End date: 2021-09-30
Duration (months): 57.0
Total project cost (EUR): 5999178.75
EU funding (EUR): 5999178.75
Participants: 14
Project status: CLOSED

Inflammatory bowel diseases (IBD) are the second most common immune-mediated disorders in Europe, affecting more particularly young people. The current therapies, including antibodies, show three main drawbacks: efficacy, tolerability and convenience. NEW DEAL solution will offer radical therapeutic progress for all IBD patients, thanks to the improved efficacy and increased safety of the specific JAK3 inhibition, which has been proven in clinics to be a target of great interest, the better tolerability of siRNA in term of immunogenicity and the good convenience with oral administration. To achieve this challenge, we will address three objectives: i) Specifically inhibit JAK 3 in a highly selective and safer manner by the mean of siRNA carefully designed and validated, ii) Deliver the siRNA therapeutic locally to the inflamed gut, by combining innovative nanostructured lipid carriers enabling their transport across the mucus, the intestinal barrier and the plasma membrane of the target cells, with polymeric capsules for protecting siRNA nanotherapeutics during their transit along the GI tract, thus allowing an oral administration, and iii) Promote the clinical translation and the future industrial transfer of this new clinical product, by addressing manufacturing, safety and efficacy evaluation at the late preclinical stage, to generate a Regulatory Submission Package and a Clinical Development Plan. The NEW DEAL project brings together clinical experts on IBD, leading scientists in nanomedicine, RNAi biology and immunology, innovative SMEs with a strong background in nanosafety, design of capsules and regulatory issues and an established pharma company with historic expertise on gastroenterology medicinal products. If successful, NEW DEAL will open new avenues for siRNA-based therapy in IBD with oral administration.

Keywords: inflammatory bowel diseases,sirna therapeutics,jak inhibition,nanostructured lipid carriers,polymer capsules,colon targeting,mucosal barrier,industrial scale up,clinical translation
Modular Systems for Advanced Integrated Quantum Clocks (MoSaiQC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria,Austria,Germany,Poland,Netherlands,Denmark,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-08-31
Duration (months): 54.0
Total project cost (EUR): 4138275.96
EU funding (EUR): 4138275.96
Participants: 10
Project status: SIGNED

Optical atomic clocks are amazingly stable frequency standards, which would be off by only one second over the age of the universe. Bringing those clocks from the laboratory into a portable form will have a large impact on telecommunication (e.g. network synchronization, GPS free navigation), geology (e.g. monitoring of water tables or ice sheets), astronomy (e.g. gravitational wave detection, radio telescope synchronization), and other fields. MoSaiQC will train 15 ESRs in this quantum technology, giving them hands-on experience in all aspects of optical clocks, from theoretical foundations, over the development of advanced components (e.g. laser systems, vacuum, electronics,...), to applications in all relevant industry sectors. The ESRs will push the boundaries of clock technology, especially in view of advanced, portable clocks and a promising, so far not realized type of clocks, superradiant clocks. Most MoSaiQC partners are also partners of the Quantum Flagship consortium iqClock, which combines academia and industry for research on optical clocks. MoSaiQC exploits the excellent research of iqClock, and goes one step beyond in its goals. We will build modules for a portable clock with higher integration than possible by iqClock and we will prepare the foundations for a portable superradiant clock. The MoSaiQC training will provide a broad range of transferable skills ranging from communication to ethics and from business acumen to gender issues. Secondment, visits, summer schools and other network events will provide opportunities to gain broad experience beyond the know-how of the hosting partner and allows the ESRs to establish long-lasting connections to international peers and stakeholders in academia and industry. MoSaiQC will prepare the ESRs for important roles in the Quantum Revolution 2.0 that is taking off now.

Keywords: optical atomic clock,superradiant clock,telecom network synchronization
Studying Multiple Sclerosis with a novel simultaneous functional Magnetic Resonance Imaging (fMRI) and Quantitative Susceptibility Mapping (QSM) sequence. (MS-fMRI-QSM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 267458.4
EU funding (EUR): 267458.4
Participants: 2
Project status: CLOSED

Multiple sclerosis (MS) is the most common autoimmune disorder to affect the central nervous system. Demyelination of nerve cells leads to a slowing of electrical signals, causing visual and sensorimotor deficits, cognitive decline and mood changes. Magnetic Resonance Imaging (MRI) plays a central role to in diagnosis through the identification of plaques and active lesions. Recently, functional MRI (fMRI) and Quantitative Susceptibility Mapping (QSM) have been shown to provide insights into the pathogenesis of MS and possible biomarkers of MS subtypes (relapsing-remitting (RR), primary progressive (PP) and secondary progressive (SP)). fMRI shows aberrant neuronal activation in response to motor tasks and changes to the motor resting state networks which are different in RR, PP and SP MS, for instance, whereas QSM provides images of the magnetic susceptibilities of different tissues, revealing iron deposits and demyelination. This action proposes the development of a new MRI sequence which will allow fMRI and QSM data to be acquired simultaneously rather than in two separate scans. This will drastically reduce the scan time, which is vital as many MS patients find it hard to stay still during an MRI. The combined fMRI-QSM sequence used to examine, in different MS subtypes and genders, reorganization of motor function and disruption of functional connectivity (from fMRI) in relation to the distribution of plaques, iron and demyelination (from QSM). The sequence programming in this interdisciplinary project will be carried out under the supervision of Prof. Barth, a physicist who developed the MR method on which the fMRI-QSM scan will be based, at the University of Queensland. In the return phase Prof. Enzinger, one of Europe’s leading MS neurologists, will supervise the clinical study with the combined sequence. This action stands to lead to a step-change in the international standing of the researcher and benefit the host and the European research area.

Keywords: multiple sclerosis,magnetic resonance imaging,functional mri fmri,quantitative susceptibility mapping qsm,ultra high field,neuronal activation,resting state networks,distortion,respiration
Upgrading Railways from the Air (Skylynx)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The deployment of advanced signalling systems (ERTMS) in Europe is encountering issues related to the use of manual and obsolete tools. Also, rail maintenance costs are still expensive in terms of effort and safety, and infrastructures lack of flexible systems to ensure security, surveillance and supervision. To resolve these problems, railways digitalisation has become a major trend within the industry. SigmaRail has developed Skylynx, a UAV-based system that aims to address these challenges to support Europe’s transportation investments (ERTMS and Galileo GNSS), by digitalising the Railways. It would add the following values bases on a high skilled and experienced core team: -Geographical data acquisition: Current main line railways need a detailed and accurate survey to capture geographical data, prior to the deployment of ERTMS. Skylynx would reduce by 30% its costs. -Assets maintenance and supervision: Equipment placed along the main line tracks in Europe are highly prone to suffer from maintenance issues. Each unpredicted failure is capable of causing service delays, as well as affecting travellers’ safety. Skylynx shall reduce costs, increasing by 15% trains frequency. -Safety: All the above tasks require workers to access the track four-foot. Skylynx, thanks to its UAV-based technology, will avoid this, increasing safety. -Security: Skylynx final deployment would ensure the control of the railway corridor access, capturing specific details and enabling expert evaluation of the railway status and access control. Thus, Skylynx is an innovative tool for railway lifecycle management, composed by UAVs equipped with sensors, nesting platforms, back-end processing nodes and a rail assets recognition software that will offer geographic information, maintenance, supervision and surveillance services of railways assets and infrastructures. The system will enable and enhance the digitalisation of the railway transportation sector.

Keywords: railway,nesting platform,signalling,maintenance,surveillance,rail,drone
CAROUSEL+ (CAROUSEL)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Finland,France,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3675521.25
EU funding (EUR): 3675520.0
Participants: 5
Project status: SIGNED

The uniqueness of the CAROUSEL+ value proposition resides in its capacity to empower meaningful visceral group social interaction to tangibly share imagination and physical movement in virtual and hybrid reality settings beyond the existing digital communication technology such as massive online game environments, peer-to-peer connections and social media networks. CAROUSEL+ technology will allow people, in small or larger groups, to feel good and have fun together. CAROUSEL+ will pave the way for the emergence of social- physical behaviour of digital characters by better understanding human body-language and being capable to interact autonomously with a group of people. The project will lay the new technical, and scientific, foundation for social and physical real-world AI by inventing, examining, simulating, developing, testing and validating human-digital interaction scenarios. The dream of the project is to create a sustainable innovation ecosystem of young talents around a new research path to design AI enabled digital characters which understand the social body language and can interact in a social and physical way with humans. CAROUSEL+ wants to lay the technical foundation for “social enabled” digital characters. The innovation perspective of this new branch “Real-World Social and Physical AI” is tremendous as it can be applied to many applications in many areas, for physically interacting in a meaningful social way. In particular digital characters in the future could act as physical trainers, dancers, entertainers, actors, co-workers, health assistants, guides, educators, spectators, physical therapists and companions. Beyond social, entertainment, health and educational applications, CAROUSEL+ learning and understanding of body language and group dynamics could be deployed in many other areas, including security, peace-making, emergency handling and autonomous driving.

Keywords: ai driven agents,real and physical real world ai,social interaction
Sustainable and Advanced Membranes By Aqueous Phase Separation (SAMBA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Membranes play a critical role in the production of safe drinking water and in the treatment of human waste streams. However, membranes themselves are nearly always produced using costly, harmful and environmentally unfriendly aprotic solvents such as N-methyl-pyrrolidone (NMP), dimethylformamide (DMF), or dimethylacetamide (DMAC). This proposal describes a highly novel approach allowing the production of the next generation of advanced membranes without the need to use any organic solvents. Here we make use of so-called responsive polymers that can switch under aqueous conditions from a hydrophilic to a hydrophobic state by a simple change of, for example, pH. In the hydrophilic state, water dissolves the polymers and the so obtained solution can be cast as a thin film. Sudden immersion in a bath at a pH where the polymer becomes hydrophobic, leads to very sudden phase separation whereby the polymer coagulates into a porous film, a membrane. Control over the kinetics of this aqueous phase separation process allows for the fabrication of a large variety of porous structures. Furthermore, this process also works for two oppositely charged polymers, where polyelectrolyte complexation is used to induce phase separation. Crosslinking will be a natural way to guarantee membrane stability but can also be used to further modify/improve membranes. The very nature of this aqueous phase separation process is such that membrane additives that are typically associated with advanced membranes (responsive polymers, enzymes, polyzwitterions, metallic nanoparticles) can readily be incorporated. As such, aqueous phase separation not only allows solvent free membrane production, it also provides a very simple and versatile route for the production of membranes with advanced properties. Finally, the porous structures and novel materials developed within this project could be directly useful for other applications, ranging from adsorption processes and coatings to biomedical materials.

Keywords: membranes,membrane production,responsive polymers,polyelectrolyte complexation,non solvent induced phase separation nips,blending
Bio-based recyclable, reshapable and repairable (3R) fibre-reinforced EpOXY composites for automotive and construction sectors. (ECOXY)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Italy,Spain,Spain,Belgium,Poland,Belgium,France,France,France,Netherlands,Denmark
Call: Biopolymers with advanced functionalities for high performance applications (H2020-BBI-JTI-2016, 2016)
Start date: 2017-06-01
End date: 2020-11-30
Duration (months): 42.0
Total project cost (EUR): 4850960.0
EU funding (EUR): 4850960.0
Participants: 17
Project status: CLOSED

Fibre reinforced thermoset composites (FRTCs) are attractive materials for high demanding sectors, such as automotive or construction, due to their lightweight and excellent mechanical properties. However, the lack of reprocessability and difficulty for repairing and recycling significantly increases the overall material cost and causes grave environmental concerns. Additionally, the vast majority of polymer matrices and fibres used in their manufacturing are non-renewable fossil-derived materials or require high amounts of energy for their production. Aiming at addressing those limitations by involving the European bio-based industry, ECOXY will develop innovative bio-based epoxy resins and fibre reinforcements to produce new sustainable and techno-economically competitive FRTCs by targeting advanced functionalities: reparability, reprocessability and recyclability (3R). The 3R functionalities will be achieved by using new resin formulations replacing commonly used curing agents by dynamic hardeners, which under certain operational makes possible to: 1) repair fibre/matrix delamination and matrix micro-cracks, 2) reprocess cured laminates could be reprocessed to create new 3D parts (impossible with traditional FRTCs), 3) mechanical and chemical recycling. Thus, ECOXY will develop: 1) tailor-made bio-based epoxy monomers (including biorefinery products), 2) upgraded and functional bio-based fibres (natural and PLA), 3) specific formulations for FRTCs manufacturing processes (RTM, wet compression moulding and pultrusion) and 4) additional functionalities such as flame-retardancy for 3R resin and self healing for fibres. The selected prototypes will be validated for automotive and construction sectors using relevant standards and applicable certifications. Besides, an environmental (LCA) and socio-economic assessment of the results will be carried out. The well balanced composition of the consortium, 6 SME, 6 RTO and 1 academia gives ECOXY the maximum chance of succ

Keywords: bio based resins,bio based fibres,reprocessability,repairability,recyclability,fiber reinforced composites,biorefinery,flame retardancy,self healing,automotive,construction