Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A biorefinery for upcycling coffee waste into sustainable, healthy, high-value ingredients (KB-BIOREFINERY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Denmark
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2021-11-01
End date: 2024-03-31
Duration (months): 29.0
Total project cost (EUR): 3558125.0
EU funding (EUR): 2490687.5
Participants: 1
Project status: CLOSED

Kaffe Bueno has developed an innovative model for upcycling coffee waste into high-value ingredients. Coffee is highly bioactive with huge reservoirs of lipids, melanoidins and phenols. Yet we currently use just 1% of its potential. Discarded coffee waste ends up in landfill, producing methane and CO2, or is reused as biofuel or compost. Kaffe Bueno transforms this wasted resource into a business opportunity. We produce high quality coffee oil, melanoidins and lignin/phenols as sustainable, natural active ingredients, sold B2B to manufacturers of cosmetics and personal care products, helping Denmark and the EU meet their targets for carbon reduction by 2030. We aim to valorise 100% of our coffee waste feedstock. In this project, Kaffe Bueno will build and optimise a demo biorefinery with the capacity to process 200 tons of coffee waste /year, using our efficient, proprietary process, then use equity to expand this plant’s capacity to 1200 tons and invest in R & D for new applications.

Keywords: coffee,active ingredients for cosmetics,nutraceuticals,cosmetics,functional food,bio refinery,coffee waste upcyling,natural products
Knowledge for improving indoor AIR quality and HEALTH (K-HEALTHinAIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Spain,Poland,Austria,Norway,Ireland,Netherlands,Portugal,Germany
Call: Indoor air quality and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7984484.5
EU funding (EUR): 7984484.0
Participants: 19
Project status: SIGNED

K-HEALTHinAIR aims at the assessment of the indoor air quality (IAQ) effects in health on the basis of an extensive monitoring campaign of chemical and biological indoor air pollutants in several very representative at EU level indoor locations together with a deep research on their sources, interactions and main correlations with health problems by means of theoretical analysis, clinical trials and tests (includes in vivo/vitro approaches). Moreover, Project will deliver affordable and easy for implementation measurements to monitor and improve current IAQ. The project will deliver structured knowledge coming from both the monitoring, characterization and research stages formed by extensive and accurate data, qualitative information and guidelines in an easy and fully open access format to support public authorities, policy makers and many other collectives. Project will also deliver innovative equipment and associated tools to the citizens as main final users enabling them to monitor indoor air quality for identifying health risks and suggesting suitable solutions to mitigate them. The advanced knowledge will be obtained by means of the deployment of a set of fully complementary activities. The organization and publication of the knowledge generated in a fully open access platform looks for being considered a reference in accuracy and simplicity to favor easy consultation from public authorities and policy makers and support the definition of new legislations, regulations and standards. K-HEALTHinAIR ensures the integration of the existing legislation (e.g. in work places) within a comprehensive proposition of new indoor air quality standards leading new science-based regulations. K-HEALTHinAIR will deploy activities leading to effectively engaging most of the collectives concerned verifying that project results will impact as it is expected. Project K-HEALTHinAIR is part of the European cluster on indoor air quality and health (name and acronym to be decided)

Keywords: indoor air quality human health terminals and sources identifications
Patronage and European perspective in Brandenburg Prussia: the painter Etcher Johann Friedrich Wentzel (1670-1729) (EuBrand)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: TERMINATED

EuBrand sheds light on a forgotten chapter of Europe’s intellectual and artistic history based on the following research question: how did painting contribute to the creation of a visual language of absolutism during the reign of the first Prussian king Frederick I? EuBrand fosters research and innovation by combining historical enquiry and augmented reality technology. At the very beginning of its life as a Nation State, Brandenburg Prussia, and Berlin in particular, experienced the afflux of immigrants artists and masters, fleeing France after the revocation of the Edict of Nantes (22 October 1685). Their presence in Berlin would change forever the city from a productive, social, artistic and aesthetic point of view. Brandenburg had never had before inborn artists. The first ones become visible only after the Huguenots' migration. One of them is the first Berlin-born painter and etcher Johann Friedrich Wentzel (1670-1729), whom Frederick I King in Prussia commissioned the monumental ceiling frescos of the newly transformed Berlin Castle. EuBrand emphasizes the importance of migration and movements of people across Europe in the creation of an iconography of absolutism functional to Frederick’s dynastic project. Wentzel’s personal and artistic trajectory is exemplary in this respect. His activity at the castle will provide the basis for an innovative app for visitors of the newly inaugurated Humboldt Forum, highlighting the forgotten layers of Brandenburg’s history behind one of the major landmark of today’s Berlin. EuBrand speaks in a timely way to the ongoing debate on the restitution of the Berlin’s castle, allowing a better understanding of the site. It contributes to the denationalization of German historiography and meets the need for accessibility and engaging story-telling in cultural heritage by exploiting the potential of the digital transition for research and curatorial purposes.

Keywords: johann friedrich wentzel,berlin castle,iconography and power,digital curatorship
INCREACE - INCREASING RECYCLED CONTENT IN ADDED VALUE PRODUCTS FOR A RESILIENT AND DIGITIZED CIRCULAR ECONOMY (INCREACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Netherlands,Slovenia,Finland,Spain,Italy,Switzerland
Call: Paving the way to an increased share of recycled plastics in added value products (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 7289051.0
EU funding (EUR): 7289051.0
Participants: 19
Project status: SIGNED

Increasing the share of recycled plastics in new products is a central aspect of the European Strategy for Plastics, adopted by the European Commission in 2018 as a part of the first Circular Economy Action Plan (2015). One of the main goals of the Strategy is to ?ensure that by 2025 10 million tonnes of recycled plastics find their way into new products on the EU market? , against less than 4 million tonnes in 2016. However, in 2016 only 8.4 million tonnes of plastics went to recycling facilities as input material. For this reason, the collection rate has to improve significantly and more collected material needs to reach recycling facilities instead of being incinerated or landfilled. Additionally, the demand for recycled plastics needs a boost, especially in added value applications where the current share is still zero or very low. Another precondition for the uptake of recycled plastics in added value products is trust. On the supply side, definitions, standards and traceability will help OEMs integrating recycled plastics into their business models. On the demand side, general acceptance of new materials will be crucial from all stakeholders, including manufacturers and the general public. The INCREACE project will tackle above mentioned issues through innovative and interdisciplinary solutions along the entire plastics recycling value chain embedded in a systemic framework. The project partners will develop new data-driven sorting solutions, combine complementary recycling technologies to increase the recycling yield and introduce new digital verification methods (blockchain) to create the required trust in the industry. The consortium will collaborate beyond organisational and sectoral boundaries to develop specific business-cases to proof the concept. The partners will provide targeted inputs into standardisation, policy making and foster active and inclusive engagement oof all relevant stakeholders as actors of the circular plastic transition.

Keywords: circular economy,plastics recycling blockchain sorting recycled content business cases,electronics,added value products,chemical recycling,solvent based recycling,empowering people
Future Proofing Health- and Care Systems Safeguarding Health Care Workers in Hospital Settings (KEEPCARING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Netherlands,Italy,Portugal,Estonia,France,Denmark,Belgium,United Kingdom,Norway
Call: Resilience and mental wellbeing of the health and care workforce (HORIZON-HLTH-2023-CARE-04, 2023)
Start date: 2024-07-01
End date: 2028-06-30
Duration (months): 48.0
Total project cost (EUR): 5687783.75
EU funding (EUR): 5687783.75
Participants: 20
Project status: SIGNED

BACKGROUND: Healthcare professionals working in hospitals and those in training to embark on hospital careers experience high levels of stress, especially in the surgical pathways. While interventions to improve wellbeing and resilience exist, not much is known about the right (combination of) intervention(s) for this specific setting. AIM: KEEPCARING aims to (re-)build wellbeing and resilience of healthcare workforce in EU hospitals by co-creating a multi-faceted non-digital, digital and AI-supported solution package to prevent burnout among (aspirant) healthcare professionals on the individual, team, and organisational level. APPROACH: Our multi-sector and interdisciplinary consortium will (1) study stress and stressors experienced by (aspiring) health care providers in their specific setting, (2) evaluate digital and non-digital solutions to reduce stress at an individual and team level, (3) study job crafting among (aspiring) health professionals as a way to reduce stress, and (4) finally, develop a change management platform that, using explainable AI, helps hospital managers as well as surgical caregivers to choose the solutions that match their context. All solutions as well as the portal will be developed in co-creation with end users, including 2 professional associations in our consortium. In addition, legal and ethical expertise is provided across Partners and in Advisory Board to ensure privacy and ethical guidance in this sensitive context. IMPACT: KEEPCARING will provide solutions to improve wellbeing among health care professionals and students, thereby reducing burnout and improving the number of health care students entering the workplace. Our organisational solutions will empower individuals and employers to understand and act on stressful situations in their specific setting. Cost-effectiveness analyses will be used for policy recommendations to ensure sustainable uptake among policy makers, funders, and employers.

Keywords: stress,resilience,nursing,surgery,students,hospital,digital tools,vr,team based approaches,organisational interventions,individual interventions,ai,co creation
Intelligent and Proactive Optimisation for Service-centric Wireless Networks (IPOSEE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,United Kingdom,China,Greece
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 467228.57
EU funding (EUR): 372600.0
Participants: 6
Project status: SIGNED

Wireless networks have become indispensable to citizens, enterprises and vertical industries, e.g., transport (including autonomous vehicles and drones), logistics, utilities and manufacturing, because wireless connectivity is essential to the digital transformation of industrial and business processes and customer experiences. As a result, wireless networks are facing increasingly diverse service requirements, which indicate that existing reactive network management will be insufficient, while intelligent and proactive control of service-centric networks becomes essential. Future intelligent wireless networks rely on several multidisciplinary breakthroughs: (i) Artificial Intelligence (AI) algorithms that can accurately predict spatial-temporal patterns of service demand and thereby drive proactive optimisation of wireless networks, (ii) reconfigurable radio access networks (RAN) and wireless environments, and (iii) automated wireless service provisioning with reduced cost, improved performance and greater reliability. Current research to automate the optimisation of service-centric wireless networks using data-driven AI is facing many open challenges that need to be urgently addressed. In this project, we will take advantage of growing data availability and advanced data science technologies, as well as AI algorithms and techniques to deliver the above identified multidisciplinary breakthroughs, thereby enabling reliable automated wireless service provisioning.

Keywords: service centric,wireless traffic forecasting,spatial temporal pattern,data analytics,uncertainty quantification,radio access network,intelligent reflecting surface,built environment,o ran ric
Adaptive redox regulation in inflammatory macrophages (Redox in macrophages)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Macrophages are key players of the innate immune system and as such maintain homeostasis, initiate inflammatory and redox responses for pathogen defence, but also regulate resolution of inflammation. Supporting these functions are distinct metabolic programmes, which underlie macrophage functional phenotypes. While recent advances have improved the understanding of macrophage metabolic programmes supporting specific activation states, it remains unclear how the redox system is regulated in macrophage activation states and during pathogen defence. Here, I propose to investigate how redox adaptation is regulated during macrophage activation and its impact on functional phenotypes. I will focus on the following three aims: Firstly, I will quantify expression of cystine transporter SLC7A11, which, by importing cystine supports glutathione and coenzyme A synthesis. This will allow a better understanding of the role of cysteine during redox adaptation in comparison to the well-known heme oxygenase 1 (HO-1). Secondly, I will disrupt key regulators of redox adaptation, including SLC7A11 and HO-1 to investigate their effect on macrophage functional phenotype. This will identify key nodes for redox adaptation in different macrophage activation states. Thirdly, I will investigate the temporal profile of electrophilic stress and redox adaptation in response to macrophage activation and during bacterial infection. Overall, this project will contribute to the detailed understanding of redox adaptation during macrophage activation, which is essential for pathogen defence and protection from oxidative stress. Furthermore, identification of new drug targets for redox regulation in macrophages would provide the basis for novel therapies for oxidative stress induced pathologies.

Keywords: macrophages,redox system,immunometabolism
Unravelling the epigenetic mechanisms underlying nutritional programming for sustainable aquaculture (EPIAQUA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500067.19
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Aquaculture supplies half of the fish consumed by humans, being the fastest growing food production sector worldwide. Reducing the use of fishery products in aquafeed by replacing them with more sustainable ingredients is a must to reach sustainability and meet future global food needs. In this sense, nutritional programming is a promising strategy with potential to increase production efficiency and fish health and minimize environmental impact. Epigenetics is thought to be responsible for the beneficial effects of early nutritional intervention, but, the mechanisms by which different types of nutritional interventions induce epigenetic modifications, and which ones they induce is largely unknown. EPIAQUA is an innovative and timely project that will unravel the multi-layered epigenetic entanglement underlying nutritional programming and its transgenerational inheritance, using Nile Tilapia (Oreochromis niloticus) as a model, paving the way for advances in the use of sustainable aquafeeds. Specific goals are: 1) to elucidate cause-effect relationship of carbohydrate content and dietary fatty acids early intervention on the multi-layered epigenome, 2) to generate a better mechanistic understanding of the phenotypic changes induced by nutritional early intervention, and 3) to demonstrate the presence of epigenetic marks transgenerationally inherited and characterize the mechanisms underlying it. The new hypothesis that lncRNAs play a key role in the transmission and long-lasting effects of nutritionally mediated phenotypes is central to this proposal, being one of its ground-breaking elements and having major translational impacts. Moreover, EPIAQUA outcomes will provide novel mechanistic insights into the role of epigenetics in nutritional programming and identify novel epigenetic markers involved in tailoring metabolic pathways for better use of sustainable aquafeeds, what in turn will drive changes in husbandry protocols, and improve aquaculture sustainability.

Keywords: aquaculture,sustainable aquafeeds,nutritional programming,multigenerational,epigenomics,long non coding ribonucleic acids,dna methylation,histone modifications,fatty acids,carohydrates,metabolic response
TWINNING TOWARDS SCIENTIFIC AND TECHNOLOGICAL EXCELLENCE IN PLANT PROTEIN RESEARCH (PROTWIN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Türkiye,Denmark,Belgium,Italy,Spain
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1499531.25
EU funding (EUR): 1499531.25
Participants: 23
Project status: SIGNED

Three key global drivers underpin the increased interest in plant protein-based diets: population-growth, important role of proteins in a healthy diet, and the environmental impact of animal-based food chains. While an increasing trend in proportion of plant sources included in diet is obvious, the current generation of commercial plant-based alternatives is suboptimal. More research is needed to obtain a comprehensive understanding on the impact of plant proteins on technological and nutritional functionality, including their digestibility and effect on gut microbiota. Despite high potential of protein crops in Türkiye and TÜBİTAK’s national reputation in plant-protein research, this is not sufficient for its scientific recognition among the EU's leading Institutes. Therefore, TÜBİTAK must improve its scientific and technological capacity, build a strong international network, and fill the gaps of this emerging protein for food field. In this context, PROTWIN is the most appropriate tool for TÜBİTAK to build a capacity development system at national and EU levels and being able to timely capture opportunities in the field of plant proteins research. The overall objective of PROTWIN is to stimulate scientific excellence, widening and strengthening networking activities between TÜBİTAK and top-class leading counterparts in EU in “plant protein innovation for food domain” by linking it with Aarhus University, University of Liege and CNR-ISPAAM. The significant complementarities between these institutions, processing, digestion, and gut microbiota for health, and -omics analytical platforms will enable through networking excellence in research and innovation, through knowledge transfer and exchange of best practice. PROTWIN will help raise the research profile of TÜBİTAK as well as the research profile of its staff. The mutual benefits of PROTWIN partnership will secure new joint research projects in the plant protein domain and provide continuity in the future.

Keywords: plant proteins for food protein modification protein diversification bioactive peptides,gastrointestinal system simulation