Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Repair of DNA lesions induced by platinum drugs (REAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 2
Project status: CLOSED

DNA damage-inducing platinum drugs, such as oxaliplatin and cisplatin, are used to treat about half of all patients receiving chemotherapy. Although potentially very efficient, many patients develop resistance for yet unrecognized reasons. Better understanding of the DNA damage response (DDR) to platinum-DNA lesions is therefore much needed for improving treatment outcomes. By performing DDR-dedicated CRISPR/Cas9 knockout screens, the applicant has shown that some cancer cells deficient in the major repair of bulky DNA lesions, global-genome nucleotide excision repair (GG-NER), are insensitive to oxaliplatin but sensitive to cisplatin. This striking difference remains as of yet unreported, but might explain differential responses of tumors to drugs. The aim of this proposal is to understand why GG-NER is unable to repair oxaliplatin lesions in particular genetic backgrounds. To do so, unbiased identification of genes differently mutated or expressed in oxaliplatin-sensitive versus insensitive cells will be followed by validation and in-depth functional characterization of identified targets. The ambition is to extrapolate experimental observations to translational knowledge. Validated targets will be studied in patient-derived tumor tissues as compared to nonmalignant tissues and related to patients’ treatment responses. Identification of genetic factors that regulate platinum lesions recognition by GG-NER will contribute to the understanding of molecular principles of platinum drugs cytotoxicity and might thus have considerable benefit on current cancer treatment schemes. The novelty of the pilot data, the unique multidisciplinary design of the project, the use of state-of-the-art molecular techniques and a collaboration with multiple European experts will ensure high scientific impact. Both, the applicant and the host will greatly benefit from the vital knowledge transfer. This project follows the European Union's commitment to cancer research.

Keywords: dna repair,nucleotide excision repair,dna damage,platinum drugs,cancer
A sustainable, affordable scalable hydroponic system for large-scale agriculture (Phytoponics)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global population is expected to grow rapidly to reach 9 billion by 2050 increasing pressure on farming and food production. Securing a sustainable and affordable method to meet this demand is a global challenge. Hydroponics has been identified as the most efficient way to grow since farmers can plant 4 times the number of crops as in the same area for soil farming, no herbicides or pesticides are required for crop growth thereby reducing the environmental impact and certain crops can grow twice as fast using hydroponics than soil. Phytoponics have developed a revolutionary patent pending hydroponic growing system that is going to transform agriculture and make fresh produce abundant. Capable of delivering high return on investment at an affordable price, Phytoponics is the first company offering Deep Water Culture technology geared to the hectare scale, giving huge productive benefits to the commercial grower, at half the cost of current offerings, enabling: high produce quality and value; high consistent yields; and high resource efficiency. The system integrates the novel smart growing sack with existing irrigation systems and automated farm management for seamless conversion to hydroponics. Within the overall innovation project, Phytoponics will finalise the scale-up engineering of the Phytoponics system; incorporate electronics to enable the smart systems; scale-up industrial manufacturing; and perform a large-scale demonstration of the hydroponic system involving farmers in the UK and Italy to successfully validate the technology prior to commercialisation. The feasibility study will be an important step to achieving these goals by enabling Phytoponics to undertake the necessary agroeconomic analysis and define the optimal business model, revenue pricing and go-to-market strategy. It will also enable us to scout and select missing players in the value chain and plan, in detail, the remaining engineering and trials to be undertaken.

Keywords: hydroponics,deep water culture,kratky,sustainable farming,aquaponics,food demand,agritech,water effciency,agroeconomics
Spatiotemporal evolution of the hydrological cycle throughout the European continent during past abrupt climate changes (STEEPclim)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1847546.0
EU funding (EUR): 1847546.0
Participants: 1
Project status: CLOSED

With global temperatures on the rise due to anthropogenic greenhouse gas emissions, one of the largest short-term threats to societies comes from a changing water cycle: changing ocean currents and atmospheric circulation patterns, increased periods of drought or extreme precipitation events directly affect the socio-economic foundation of communities. However, one of the great unknowns in state-of-the art climate models predicting future changes is the spatial distribution of changing precipitation patterns. This lack of knowledge severely limits implementation of mitigation and adaptation options to divert the most severe consequences of climate change. I propose a fundamentally new approach to understand spatial patterns and mechanisms of hydrological changes on the European continent by reconstructing such changes during past abrupt temperature and ocean circulation changes. We will develop an innovative research program integrating ideas and methods from diverse disciplines: organic geochemistry, plant physiology, event stratigraphy and geostatistical data analysis. We will generate quantitative paleohydrological data by developing a dual biomarker approach as a novel and direct proxy for fluxes in the hydrological cycle from 10 of the most precisely dated terrestrial climate records encompassing the European continent. STEEPclim will enter uncharted territory and establish master records of continental climate change, comparable in resolution and quality to the polar ice cores. We will identify continental-scale feedback mechanisms and particularly vulnerable regions in European hydroclimate relevant for the evaluation of the consequences of ongoing climate change. These mechanistic insights will be essential to validate future generations of climate models, ensuring more accurate predictions of regional effects of anthropogenic climate changes and as such enable a targeted mitigation and adaptation policy.
Additive Micro-Manufacturing for Plastic Micro-flectro-Mechanical-Systems (MEMS 4.0)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-05-31
Duration (months): 68.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The manufacturing of silicon-based MEMS today is well advanced because the micro-electro-mechanical devices for automotive, domestic, health-care and consumer electronics can be fabricated with methods from IC industry. Polymer-based MEMS have a great potential for flexible electronics and biomedical applications, but to date, the techniques to engineer functional polymers into 3D microsystems, are still at their beginning because a coherent fabrication platform with the right tools and processes does not yet exist. The field could tremendously benefit from a coordinated effort in materials and manufacturing, in particular with a focus on biocompatible plastic materials for biomedical applications. Additive manufacturing such as 3D printing and associated processing such as sintering has already started to transform traditional industry, but is not scalable much below a micrometer because the thermal processing is done in bulk or by lasers on surfaces. MEMS 4.0, in analogy with the industry 4.0 concept, aims to perform concerted research in additive manufacturing at the micro/nanoscale and associated key techniques. Using my expertise in MEMS and Nanotechnology, MEMS 4.0 will push the frontiers in new materials and new processing for MEMS by setting a focus on stencilling, printing, self-assembly and local thermal processing. This coherent processing framework will permit the use of delicate, soft, polymer materials to engineer the next generations of plastic MEMS. We are primarily targeting biodegradable implantable MEMS and permanently implantable glassy carbon MEMS. They are the most challenging to fabricate, but if successful, they also have an enormous impact for future wearables and implantables.

Keywords: inkjet printing,nanostenciling,thermal nano processing,glassy carbon,additive micro manufacturing,self assembly,biodegradable,implantable
Water Quality in Drinking Water Distribution Systems. (Wat-Qual)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Italy,Germany,Norway,Serbia,Serbia,France,Czechia,Netherlands,Netherlands,United States,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 243000.0
EU funding (EUR): 243000.0
Participants: 20
Project status: CLOSED

Safe drinking water is paramount for the health and wellbeing of all populations. Unsafe drinking water can contain pathogenic microorganisms and/or chemicals that can make people immediately unwell or can potentially cause serious illness over prolonged exposures. Within the EU, water is extracted from surface and groundwater sources and treated to comply with EU drinking water standards under the Water Framework Directive and Drinking Water Directive. The water is then circulated through the drinking water distribution system (DWDS). During travel within the DWDS, water quality can deteriorate due to microbiological growth, chemical reactions, interactions with ageing and deteriorating infrastructure, and through maintenance and repair activities. Water utilities within the EU are administered at the local level, i.e. city or county region and while they adhere to the overarching EU directives governing quality, they can choose their own treatment protocols, maintenance procedures and hydraulic operations. Some DWDS actions such as flushing may serve to improve water quality, however, these can also adversely impact the drinking water system and cause instances of poor water quality or disease outbreaks. We propose to bridge the gap between science and practice, involving water utilities and researchers from multiple locations across Europe along with third-country expertise, to examine DWDS operational practices and use scientific research approaches to better understand the water quality impact of different interventions to develop a suite of best practices which can be shared to ensure that the EU’s water remains clean and safe. We have assembled a multi-disciplinary, cross sectoral consortium to address various aspects of DWDS practices including flushing, chlorination and system maintenance.

Keywords: drinking water distribution systems,chlorination,maintenance,water utilities,flushing
An innovative, low-carbon window characterised by ultra-high thermal performance created using the most sustainable and energy efficient manufacturing processes. (INVISIBLE WINDOW)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

An innovative low-carbon window with glass-only edges, with an energy performance unrivalled by any other on the market. A window which significantly reduces thermal dispersion, having a low transmittance rate almost comparable with that of an Insulated Glass Unit (IGU) – currently the least dispersive component in a window. To achieve ultra-low energy dispersion rates, INVISIBLE WINDOW eliminates the frame around the edge of the glass (the part most dispersive and prone to wear), significantly reducing its size, and places it between the two panes of the IGU. In this way, the low-profile frame cooperates structurally with the glass; all this owing to a joint made with high-performance structural adhesives, mainly used in the nautical and aeronautical sectors. The low-profile frame can be made of aluminium with a thermal break, wood or of GFRP (composite materials with high mechanical properties). The INVISIBLE WINDOW has a reduced component count compared with traditional windows and uses a minimal amount of base material for its frame. The resulting technological simplification reduces energy consumption during the production phase and reduces the environmental impact of transport and disposal (MJ -27%). INVISIBLE WINDOW can be installed effortlessly in both new buildings and those to be restored, with any type of glass or opening, maintaining a high thermal and mechanical performance, stylish design at a competitive price. Starting from the patent, further high-TRL options may be selected during the feasibility study for the subsequent prototyping and testing phases. Vetro Marche snc is closely following all the necessary steps that will lead, in the future, to the expansion of its production line to market a finished window. As evidenced from preliminary window market analysis, the market is eagerly waiting for a product like INVISIBLE WINDOW. Vetro Marche’s market strategy intends to start the commercialisation process in the Italian, French and German markets

Keywords: sustainability,low carbon window,eco friendly design,energy efficiency in buildings,high,performance
Ultra-low-cost terminals that meet the special requirements of all satellite operators allowing them to access markets currently inaccessible due to terminal economics. (RF Beamformer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Broadband has become an essential part of 21st-century infrastructure. New cloud services are making it a necessity for starting and growing small businesses, as well as advancing a wide variety of industries. However, more than half of the world's population still does not have access to internet being at a disadvantage; and the digital gap will continue to grow wider. Traditional wireless networks are expensive to install or expand and consequently low subscriber areas and less lucrative developing regions will likely never see cellular access. As an alternative, satellite access offers more than 5,000 times the spectrum compared to terrestrial networks -plus it is global and cover land, sea and air. Nevertheless, this technology is held back by current ground-based terminal (antenna) solutions that are expensive, single beam, require high power and have limited scalability. Isotropic’s Radio Frequency (RF) Beamformer technology is a highly innovative system that exploits the science of transformational optics to provide the self-aligning ability of large phased array antennas but with significantly reduced complexity. This allows for drastically reduced cost and power consumption whilst increasing operational flexibility and performance. RF Beamformer is an ultra-low cost antenna technology that enables an optimised ground-based terminal that is otherwise currently missing in the industry development roadmap. To date we have received $6M in venture capital and following successful results from founder´s research, the technology has reached TRL 5. We are now looking for funds to following our detailed product roadmap, translate our technology to products and bring satellite connectivity to the mass market by 2021. The proposed work in Phase 1 of the SME Instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of RF Beamformer and its market uptake.

Keywords: antenna,satellite broadband,transformational optics,geo meo leo satellites
A new crop protection strategy by chemical priming of the plant immune system (ChemPrime)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 148318.0
EU funding (EUR): 148318.0
Participants: 1
Project status: CLOSED

A large proportion of global crop yield is annually lost to plant diseases. While pesticides help to reduce these losses, there are growing concerns about pesticide resistance and their impacts on health and environment. The objective of this proof-of-concept project is to develop a crop protection technology that is based on priming of the plant’s own immune system, providing an enhanced defensive capacity to resist attackers. While priming is considered attractive for exploitation in integrated pest and disease management, chemical priming agents have never reached their full economic potential due to undesirable non-target effects on plant growth and yield. My former ERC project (‘Prime-A-Plant ́) has revealed key insights in the mechanisms by which plants perceive and respond to priming-inducing chemicals. We showed that the benefits of priming by beta-aminobutyric acid (BABA) can be uncoupled from the associated stress response (Luna et al. 2014; Nature Chem. Biol.). More recently, we discovered a structural analogue of BABA, R-beta-homoserine (RBH), which primes plant defences against multiple diseases without affecting growth (Buswell et al. 2018; New Phytol.). The current ‘ChemPrime’ project aims to develop these discoveries into a crop protection strategy through co-design with commercial stakeholders. The first project part involves translational research to make the concept more attractive for adoption by commercial stakeholders. We will examine the effectiveness of RBH against a range of economically relevant crop diseases, identify genetic targets in crops to improve the effectiveness of the RBH priming response, assess chemical residues in crop products and waste streams, and optimise RBH formulation for applications in different production systems. The second project part involves engagement activities to initiate collaborative research & development with agri-tech companies and develop the concept into a commercially viable crop protection strategy.

Keywords: plant immune priming,crop protection,chemical priming agents,plant disease resistance,genetic crop improvement
Improved glioblastoma treatment through targeted, local drug delivery (TARGLIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of this project is to develop a business plan to guide clinical development and commercialisation of SI053; a novel gel formulation for the treatment of the most common and aggressive type of brain cancer called glioblastoma. Glioblastoma affects approximately 2-3 people in every 100,000 each year in Europe and has an extremely poor prognosis. 50% of patients die within a year and 90% die within three years. A combination of treatments are used to treat patients but are limited in their efficacy due to the physical location of the tumour and the aggressiveness of the condition. Double Bond has developed SI053, a unique polymer matrix that contains temozolomide to locally treat brain tumours without harming healthy tissue. Temozolomide is a first line, highly potent chemotherapeutic. When administered systemically, it is highly toxic to healthy tissue and its final concentration is significantlly reduced since it has to cross the blood brain barrier. Also, it cannot be administered right after surgery, delaying chemotherapy by a few weeks. Double Bond’s drug delivery platform allows a high concentration of temozolomide to be released slowly and directly to the tumour right after surgery. Research to date on SI053’s use as a treatment for glioblastoma has been highly promising. Double Bond now aims to clinically validate SI053 in a clinical trial, demonstrating proof of concept. The current proposed Phase 1 project will facilitate in the development process and help define clinical and business strategies. SME Instrument funding will allow SI053 to take a substantial step along the path of commercialisation.

Keywords: glioblastoma,temozolomide,drug delivery