Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the Role of Glycans in Human Norovirus Infection: a Key to Unlock New Therapies (GlycoNoVi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Belgium,Denmark,France,Netherlands,Germany,United Kingdom,Spain
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2765371.89
EU funding (EUR): 2412295.2
Participants: 15
Project status: SIGNED

Glycans are carbohydrate structures ubiquitously found on the surface of cells and take part in many biological processes, including cell signaling and neoplasia. Research on glycans is challenging in part due to the limited availability of biologically relevant synthetic glycans and to technical challenges in the analysis of glycan-protein interactions. Glycans also exhibit key roles in viral infections, mediating virus attachment and entry. Human noroviruses (NoVs) are the major cause of viral gastroenteritis and foodborne illnesses causing morbidity, mortality and economic losses. NoV infections are self-limiting in healthy individuals but are associated with severe complications in immunocompromised individuals, the elderly and young children. In addition, frequently occurring new NoV genotypes and variants can cause large outbreaks and epidemics worldwide. Very little is known about NoV infections in most non-human hosts and the close genetic similarities between some animal and human NoVs leads to the realistic hypothesis that the virus might jump the species barrier triggering pandemic variants. Importantly, no therapy is currently available to treat or prevent NoV infections. The requirement for NoVs to attach to specific glycans to infect hosts’ tissues, and cells, has been well established but the underlying mechanisms remain to be elucidated. Going beyond the state-of-the-art, the overall aims of GlycoNoVi is training 9 researchers to address knowledge gaps on NoV glycan interactions and investigate the exciting possibility of developing synthetic glycans as antiviral strategies to treat NoV infection. These aims will be achieved bringing together 5 academic and 3 industrial leaders in glycoscience, glycovirology and NoV field and relying on a multidisciplinary and interconnected approach which is declinate in research-oriented WP1-5 and WP6-8 focused respectively on training, outreach and coordination.

Keywords: glycosides,small molecules,antiviral,glycovirology,norovirus
Metal complexes of a naturally inspired framework functionalized for cytotoxic and catalytic efficiency (MET-EFFECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Serbia,Bulgaria,Germany,Austria,Portugal
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 982428.57
EU funding (EUR): 763600.0
Participants: 6
Project status: SIGNED

The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.

Keywords: rhenium,iridium,flavonoid,synthesis,characterization,metallodrug,cancer,cytotoxicity,homogenous catalysis,water oxidation
The Insula-Body Loop for Neural Control of Gut Physiology (InsulaBodyLoop)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The brain and body are in a continuous dialog. Our brains constantly receive sensory information from within our body, as well as from the external environment, and then use it to regulate bodily function. Brain-body communication is essential for our physical and mental health, yet little is known about how it is achieved at the neurobiological level. A large corpus of work implicates the insular cortex as a central node in the brain's interoceptive network. Current models suggest that insular cortex integrates internal and external sensory information to regulate bodily physiology. Yet direct experimental evidence has been scarce. I propose a research program that focuses on the insular cortex as part of a dynamic loop with the gastrointestinal system, which regulates peripheral metabolic function and feeding behaviour. Two fundamental questions form the core of this proposal: (1) How do the sight, smell, and taste of a savoury dish, or a sweet dessert, enable our brains to predict the post-ingestive nutrients they will supply? (2) How are these predictions relayed to our body to pre-emptively prepare it for consumption, e.g., by inducing salivation and insulin release? To answer these questions we need to understand both cortical predictive computations, as well as peripheral physiology. I therefore propose to build on my expertise and use an inter-disciplinary approach, combining cutting-edge neuroscience and computational methods with recordings and optogenetic control of peripheral physiology. This will reveal: (1) how insular cortex represents internal sensations, (2) how insular cortex forms associations between internal and external sensory information, and (3) how these associations are relayed to the body to maintain homeostasis. This study will provide a conceptual and methodological foundation for future elucidation of how different internal sensory modalities act together within the brain-body loop to maintain our physical and emotional health.

Keywords: insular cortex interoception interoceptive predictions gustatory insular cortex post ingestive food reward gut induced reward
Loneliness Across Time and Space (LOTIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1998018.0
EU funding (EUR): 1998018.0
Participants: 1
Project status: SIGNED

The places where people live and spend their time seem to matter for loneliness, but previous research provides mixed evidence for this link. The core argument of LOTIS is that to understand why, when, and for whom places contribute to loneliness, the current perspective on the link between place and loneliness needs to be fundamentally shifted towards a dynamic view. I propose a novel theoretical framework linking a person’s momentary loneliness to how the place is subjectively perceived by this person at a given time, which in turn is influenced by the objective, observable characteristics of this place, characteristics of the person, and individual mobility patterns, i.e., how often, for how long, and in what order places are visited. To test this framework, first, a new dimensional taxonomy that allows describing perceived character-istics of places systematically and comprehensively is developed and applied to the geographically diverse city of Bochum, Germany, using a citizen science approach. Second, the short-term and long-term reciprocal dynamics of place, mobility, and loneliness will be examined in a longitudinal meas-urement burst study where participants track their current location using GPS and report their percep-tions of their current locations and their momentary loneliness four times over a period of three years. Third, the causal processes that link places to loneliness will be tested using laboratory experiments and a natural field experiment. LOTIS has the potential to significantly change how the associations among places, mobility, and lone-liness are conceptualized and studied by (a) moving from a static to a dynamic perspective, (b) incor-porating both objective and perceived characteristics of places, and (c) considering individual mobility patterns. In addition, the insights gained in LOTIS can be used to develop evidence-based interven-tions and public policy measures against loneliness.

Keywords: loneliness,socioecological psychology,mobility patterns,mobile sensing,individual differences
Data-DrIVen Solutions for Efficient PoweR DiStribution Network OpErations (DIVERSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,Greece,Kazakhstan,Italy,Romania,United Kingdom,Netherlands
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-12-01
End date: 2029-11-30
Duration (months): 48.0
Total project cost (EUR): 923987.14
EU funding (EUR): 801600.0
Participants: 11
Project status: SIGNED

DIVERSE addresses critical challenges in modern power distribution networks as they transition to accommodate high shares of renewable energy sources (RES) and increasing electrification demands. The project develops an AI-powered framework to optimize power distribution networks, supporting robust RES integration while tackling key issues such as variability and grid reconfiguration. By combining advanced machine learning, deep learning, and adaptive grid technologies, DIVERSE introduces predictive analytics, near real-time optimization, and consumer-side flexibility to enhance grid efficiency and scalability. The project's objectives include: _Developing AI-driven forecasting and regulation strategies for RES integration _Enhancing operational flexibility and efficiency through adaptive control mechanisms _Ensuring grid resilience across different network configurations _Optimizing multi-energy system coordination DIVERSE's innovative approach incorporates resilience-focused design into distributed energy resource (DER) coordination, ensuring effective grid operation under dynamic scenarios. Through simulations on RTDS-based platforms, the project optimizes adaptive response strategies, enhancing long-term grid flexibility, reliability, and multi-energy integration. The consortium unites academic institutions, SMEs, and industry partners from six countries, fostering interdisciplinary collaboration among experts in AI, power systems, and energy management. This international, intersectoral, and interdisciplinary approach ensures that DIVERSE's outcomes are scalable and adaptable to diverse grid configurations across Europe and beyond. By addressing the urgent need for innovative solutions in power distribution networks, DIVERSE contributes significantly to the EU's energy transition goals, aligning with key agendas such as the European Green Deal and the Circular Economy Action Plan. The project's outcomes will enhance Europe's energy security, reduce reliance

Keywords: optimization machine learning power distribution networks smart inverters
OBSERVATION OF ECOSYSTEM CHANGES FOR ACTION (OBSGESSION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Finland,Netherlands,Switzerland,United Kingdom,Sweden,Belgium,France,Bulgaria,Germany
Call: Interdisciplinary assessment of changes affecting terrestrial and freshwater ecosystems, building on observation programmes (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5303940.0
EU funding (EUR): 5303940.0
Participants: 11
Project status: SIGNED

The objective and key ambition of OBSGESSION is to monitor and predict biodiversity change and its direct and indirect drivers in terrestrial and freshwater ecosystems through the integration of state-of-the-art multi-sensor Earth Observation (EO) data, innovative in-situ (including citizen science) data, and products, together with next-generation ecological models that account for uncertainty. This aim goes well beyond the current state-of-the-art in combining the various data sources, modern modelling and uncertainty estimation. The methodological principles include firm anchoring into science and policy needs, true interdisciplinarity between terrestrial and freshwater as well as EO and ecosystem modelling disciplines, and FAIR and open science practices, including sharing of research outputs with both the scientific community and the civil society, to study how biodiversity across terrestrial and freshwater domains is changing and the processes and needed innovations leading to efficient science-based solutions towards observation of ecosystem changes for action.

Keywords: biodiversity conservation,earth and related environmental sciences,environment,freshwater ecosystems
Contentious Politics and Democratic Renewal in Sustainability Transitions (Trans4Demo)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Poland,Norway,Sweden,Germany,Italy,Netherlands,Denmark,Israel,Belgium
Call: Protest politics and cultures of opposition in democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2999881.25
EU funding (EUR): 2999881.25
Participants: 13
Project status: SIGNED

Trans4Demo is an evidence-based and impact-driven set of actions to address contentious politics arising from climate change and sustainable transitions. These conflicts are seen as a critical challenge for democratic systems, and their importance is expected to grow in the future. Authoritarian tendencies and right-wing populism have weakened social cohesion, making large parts of EU populations less willing to change their practices and hindering responses to climate challenges. The main objective of the project is to investigate the role and evolution of diverse forms of opposition and contentious politics of sustainability transitions, and their impact on democracy. We aim at delivering the temporality-sensitive conceptual framework, practical understandings, and policy recommendations to assist in democracy reinvigoration. By exploring these intersections, we identify specific scientific, consensus-based, and politically normative goals that political communities in diverse European contexts could pursue. Empirically, throughout the project, we will (1) focus on practical understandings of the role of various bottom-up mobilizations against the populist backdrop, (2) identify novel sites of constructive democratic engagement, and (3) address the role of trust in the democratic process, including the validity of electoral processes. Building on this, (4) we will provide sound, research-based policy recommendations that balance bottom-up and top-down perspectives for democratic renewal. To achieve these targets, we will employ triangulated and participatory methodologies, including case studies and future-oriented methods, developed in collaboration with societal actors involved in the project—from the initial design of the research agenda to fieldwork and dissemination activities.

Keywords: democracy renewal,bottom up mobilizations,contentious politics,sustainable transitions
Trust in European Democracies (TRUEDEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Czechia,France,Slovenia,Ukraine,Germany,Greece,Italy,Poland,Romania,Slovakia,Sweden
Call: Representative democracy in flux (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2977273.75
EU funding (EUR): 2977273.5
Participants: 13
Project status: SIGNED

Political trust has long been regarded as an important element of regime support and factor of regime stability; it is widely associated with a number of positive outcomes in representative democracies. Political trust drives citizens’ interest and engagement in politics, increases voting turnout and makes law-abiding behavior more common. Political trust is frequently equated to diffuse regime support and thus linked to the effective functioning and stability of the political system. The proposed research effort will monitor the structural (long-term) drivers of political trust but also emphasize the strategies which can be employed by diverse actors and agencies to strengthen accurate and informed judgments of agency trustworthiness. The objective of this ambitious project is twofold. First, we aim to design and implement a complex research effort to collect comprehensive evidence on the judgments of trustworthiness in a range of European states. Second, the project will develop a comprehensive and transparent toolbox of short-term and long-term policy interventions including recommendations, and methodologies for enhancing trust in political institutions, boosting transparency, and inclusiveness of representative systems in Europe. While there is a growing concern about the crisis of democracy and democratic backsliding, this research effort will provide an innovative theoretical perspective on the sources of regime support and strategies for trust building in the public domain. The project looks at the different drivers of 'positive high trust in democracy' and 'negative high trust in autocracy'. The project will facilitate development of a new paradigm of political trust and trust-building and will inspire emergence of new insights on the multi-facet origins of political trust and multi-factor nature of trustworthiness. The project has partners in Austria, Czechia, France, Germany, Greece, Italy, Poland, Romania, Slovakia, Slovenia, Sweden, and Ukraine.

Keywords: trust in government,in parliament,legal system,media system,political parties,interest groups,ngos,support for democracy,voting behavior,political inclusion,political integration
Engineering CAR-T cells to overcome glycosylation-driven tumour resistance (DEGLYCAR-T)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

T cells engineered to express tumour-specific chimeric antigen receptors (CAR) proved effective against B-cell tumours. However, as the technology moves to solid cancers, clinical responses have not been as robust. In this setting, several barriers need to be overcome, including poor tumour recognition and a highly immunosuppressive tumour microenvironment (TME). Altered glycosylation is a hallmark of cancer, often manifesting as incomplete synthesis of O-glycans and increased branching of N-glycans. Glycosylation can mask epitopes to antibodies recognition and suppress anticancer immunity. My Unit was the first to report that N-glycans protect tumours from CAR-T cells and that pharmacological inhibition of N-glycosylation improves efficacy of CAR-T cell therapy in solid malignancies. With the aim of generating a single cell product able to safely offset multiple barriers of tumour resistance, I propose to engineer CAR-T cells to locally express an enzyme able to de-glycosylate tumour and TME cells. This goal will be achieved through the selection of a mutant able to deglycosylate the surface proteome of target cells. To regulate its function in CAR-T cells, I plan to test different systems based on the use of specific promoters, the inclusion of artificial miRNA target sequences, or the generation of a transmembrane variant. A deep characterization of the selected product will be performed in mice reconstituted with a human haemopoietic system. This model will allow to study the efficacy and safety of the proposed approach, and to assess its ability to remodel the TME toward a pro-inflammatory state. I believe that this project will have an immediate impact on cancer immunotherapy, will fuel the development of antiviral approaches and will provide new technological platforms. I have a deep knowledge of CAR-T cell therapy and have established a great network in the field. Despite ambitious, I believe I have the right skills and tools to make this project a reality.

Keywords: chimeric antigen receptors,t cells,cancer