Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrating breeding for IPM into the deployment landscape for wheat, potatoes and grain legumes (IPMorama)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Ireland,Denmark,Netherlands,Serbia,France,Spain,Italy,Germany,Lithuania,Switzerland,United Kingdom
Call: Biodiversity friendly practices in agriculture – breeding for Integrated Pest Management (IPM) (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 4835796.25
EU funding (EUR): 4835796.25
Participants: 17
Project status: SIGNED

IPMorama will improve the state of the art in variety-centric Integrated Pest Management (IPM) for important diseases in the wheat (rust pathogens), potatoes (blight) and the grain legumes soybean, pea (broomrape) and white lupin (anthracnose). IPMorama seeks to develop the infrastructure for a whole “practice ecosystem”, whereby the more efficient development of IPM-centric varieties is enabled, while at the same time developing tools and resources to efficiently exploit these in variety-centric IPM. The core innovation of IPMorama is to integrate knowledge of host resistance with the pathogen virulence landscape over space and time, to produce IPM tools (eg crowd source apps, vulnerability maps) and strategies, which will be validated at various scales and in conjunction with different agroecological practices. IPMorama will achieve these goals by enacting the following five components: 1] Understanding the genetic composition of varietal resistance in target crop/pest systems, and development of tools and resources to allow breeders to target the assembly of resistance components. 2] Understanding and mapping the landscape level distribution of the target pathogens/pests, especially in terms of their virulence against the available set of resistance and tolerance genes in varieties and breeding lines. 3] Developing specific integrated pest management practices for the optimal exploitation of pest and pathogen resistance in varieties on the basis of the first two components. 4] Developing the knowledge infrastructure for competent use of variety-centric IPM by actors across the variety-related value chain. 5] Understanding opportunities and barriers for scale-up of variety-centric IPM solutions.

Keywords: mas marker assisted selection,gs genomic selection rapid cycle breeding,pathotypes,vulnerability mapping,crowdsourcing,kt knowledge transfer,stakeholder engagement,value chain
Revolutionizing Health Decisions: First Platform for fast, cost-effective Single-Cell and Spatial Omics analysis (SamplingONE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Single-cell omics provide precise molecular measurements that are crucial for early disease detection and treatment, yet their complex workflows and data analysis limit routine use. This restricts medical practitioners and pharmaceutical companies, resulting in less effective health outcomes. Although single-cell sequencing adoption rates in the pharmaceutical sector are high (92%), only a small portion of samples are analysed at the single-cell level due to these barriers. Innovations are urgently needed to simplify workflows, reduce costs, and enhance data analysis, unlocking the full potential of single-cell precision analysis in medicine and cell therapies. XENO Cell Innovations has developed a new class of biotechnologies that circumvents complex instruments to consolidate multiple sample preparation and screening stages into a single unified test. Our groundbreaking and patented smart encapsulation method, SamplingONE, employs multifunctional bioparticles designed for single-cell analysis in a one-step approach. This simplified workflow reduces instrument costs by 60x, sequencing costs and operational time by 10x, and scales to handle thousands of samples per week. Our first CD19 CAR-T product family kits present a global market opportunity of €1.1 billion. We are launching research-use kits by Q1 2025. We request EIC funding for blended finance to achieve the milestone of validating our kits with CAR-T therapy clinical samples by 2026. Subsequently, we aim to scale up manufacturing and deploy CD19 products globally by 2028 to generate multimillion-euro revenues. EIC funding will be essential to validate and commercialize our first product family, marking the first step toward realizing our vision to revolutionize single-cell omics. By streamlining workflows and data analysis, we aim to make single-cell technology a cornerstone of personalized medicine, improving health outcomes globally and establishing our company as a leader in the field.

Keywords: single cell omics,spatial omics,immuno cell therapy,life science tools,techbio,machine learning,advanced algorithms,disease mechanisms,biotechnology,precision medicine
LuxR solos as major proteobacterial players of cell-cell signaling in the plant microbiome (LuxSoM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 190895.12
EU funding (EUR): 190895.12
Participants: 3
Project status: SIGNED

Microbes live as members of a microbial consortium where they interact with neighboring organisms (including their host) via the secretion of signaling molecules and through other types of cell-cell interactions. The root microbiome is comparable to the ’gut microbiome’ of the plant, important for optimal root growth, nutrition and providing resistance to abiotic and biotic stresses. The major mechanisms of microbial plant-recruitment from the soil and formation of microbial communities are unknown. The practical exploitation of these mechanisms will lead to innovative solutions for a sustainable agriculture, in order to mitigate the upcoming challenge associated with climate change. Main members of the root microbiome are Proteobacteria, as they account for 50% of the bacterial population, and LUXOM project aims to generate critical insights on their assembly and cell-cell communication mechanisms via a well-defined and targeted approach. LuxR solos, which evolved from cell-cell signaling quorum sensing systems (QS), are very widespread and exclusively found in proteobacteria. They are a family of transcriptional regulators that respond to endogenous or exogenous (also of plant origin) signals. The LuxR solos will be studied by genomics, genetics, molecular biology, analytical and molecular chemistry, biochemistry, microbiome analysis and state-of -the-art mass spectrometry based technologies. The importance of bacterial LuxR solos in the plant (root)-microbiome network will be explored to unravel their influence on plant host physiology and microbial community dynamics. Understanding cell-cell signaling in the root microbiome will be used to design bacterial communities of interacting plant-beneficial strains that will serve as a probiotic for plants to enhance plant health and sustainable agricultural productivity. Thus, LUXOM will unravel the first major cell-cell signal players for plant (root)microbiome establishment.

Keywords: quorum sensing,microbiome,plant associated bacteria,luxr solo,contact independent signaling,regulation,syncom
Displaced brokers: How displaced people shape humanitarianism in an era of fragmented protection (DiShape)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Research on displaced people is often reduced to the vocabularies and imaginaries of the nation-state and multilateral and international humanitarian organisations. This research seeks to open up new perspectives in studying displaced people by moving beyond institutionalised (and fragmented) definitions and instead probing deeper into their differentiated experiences under differentiated regimes. The need for new perspectives becomes urgent as conflicts multiply and displacements of various communities are prolonged while simultaneously, the scope of asylum becomes narrower. Given this socio-political background, the project seeks to foreground a specific cadre of displaced people: those carrying out (in)formal roles in humanitarian organisations. Their mobilisation will be examined through the lens of brokerage to uncover how they are not just intermediaries or by-products of a volatile situation but rather disruptive and (re)constructive forces in a field that is in flux. To do so, a mixed methods approach that combines participant observation with elite interviews and focus groups will be applied in the case of Afghan and Syrian ‘displaced brokers’ in Turkey. This study will make three key contributions: (1) through a detailed study of the dynamic between ‘displaced brokers’ and humanitarian organisations, it will produce new data on contemporary mechanisms of exclusion and inclusion of displaced people under the differentiated protection regimes in Turkey, (2) it will make a theoretical contribution to knowledge about the transformative capacity of brokerage by linking the distinctive attributes of the contemporary Turkish refugee governance and global humanitarian mechanisms to the context of different groups emerging from different conflict contexts (3) it will provide policy-relevant analysis to reveal the role of displaced brokers as aid agents, prompting policy acknowledgement to streamline their brokering within humanitarian processes.

Keywords: forced migration,displaced people,brokerage,humanitarian organisations,turkey,displaced syrians,displaced afghans
Immune Synapse Engagement as a Novel Approach for Cancer Immunotherapy (ImmuneSynapsEngagers)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Monoclonal antibodies (mAbs) targeting immune checkpoints have revolutionized cancer treatment but exhibit several challenges, most notably, limited intratumor efficacy and relatively low patient response rates. Endowing these mAbs with immune-cell-recruitment capabilities may offer the solution to these drawbacks. This assumption is based on our recent findings that the effectivity of a given checkpoint mAb relies not only on its binding to its target T-cell’s receptor but also on the direct interaction of the targeted T-cell with dendritic cells (DCs). Our results suggest that the low-frequency or dysfunctionality of such stimulating immune synapses following checkpoint mAb treatments hinder their anti-tumor efficacy. Therefore, the outcome of not taking this T-cell-DC licensing loop mechanism into account in mAb design is suboptimal checkpoint mAbs. To overcome these limitations, we propose here to develop a series of bi- and muti-specific immune synapse engager antibodies as a new approach to enforce immune interactions for cancer immunotherapy. We will apply in-vivo genetic tools and high-dimensional analysis of the immune response on the spatial, cellular, proteomic and transcriptomic levels to provide critical insights into immune synapses that mediate effective T-cell anti-tumor activity. We will then harness this knowledge to apply antibody-engineering approaches and treatment regimens to maximize anti-tumor activity. We will explore and target T-cell-DC synapses that enable antagonistic (Aim 1) and agonistic (Aim 2) checkpoint mAbs and additional types of immune cell interactions underlying favourable immune surveillance of tumors (Aim 3). This study will introduce a novel approach for cancer immunotherapy using drugs that engage physical crosstalk between key immune cells. Ideally, this study will yield reagents with potent anti-tumor efficacy and well-characterized in-vivo activities that can be readily translated for evaluation in human patients.

Keywords: therapeutic antibodies,bispecific antibodies,cancer immunotherapy,cancer immunity,immune checkpoint blockade,
MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation (META-BRAIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Austria,Italy,Switzerland,Cyprus
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3457905.0
EU funding (EUR): 3457905.0
Participants: 8
Project status: SIGNED

The pathological alterations of neurological function (e.g., stroke, trauma, neurodegeneration, epilepsy, neuropsychiatric diseases, chronic pain) are commonly associated with alterations in brain rhythms and activity patterns. There is an urgent clinical need for treatments that can precisely control and restore neural activity, taking advantage of state-of-the-art technological developments in a variety of fields including nanotechnology, nano- and microelectronics, novel materials, brain science, clinical neurology, and computational modelling. META-BRAIN (MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation) brings together seven expert partners in these fields with the aim of achieving precise spatiotemporal control of brain activity using magnetoelectric nanoarchitectures that can be polarized by non-invasive, remote magnetic fields. This novel principle of brain activity control will minimize the amplitude of the required magnetic fields, be wireless, and have enhanced spatial resolution from single neurons to cortical areas. We will develop a model-driven fabrication of the coils and monitor the effects on brain function with arrays of graphene microtransistors that uniquely allow full-band recording, integrating all elements in a closed loop. As an alternative to remote brain stimulation we will also use novel ultrasonic technologies. The META-BRAIN control paradigm will be systematically studied in pre-clinical systems from individual neurons to the full brain. All developments and experiments will be carried out in conjunction with theoretical models that will simulate, quantify, and predict optimal arrangements and patterns for the desired output. Translation to humans will be evaluated with our clinical partners, and a detailed dissemination and exploitation plan will be developed by two expert company partners, one of which has extensive expertise in the fabrication of brain interface devices with a worldwide distribution capability.

Keywords: cerebral cortex,neuromodulation,nanoarchitectures,magnetic stimulation,ultrasonic,cmut,brain,neuroscience,graphene microtransistors,slow oscillations,brain activity
Revealing the mechanics of sub-critical rock cracking of mountains cliffs from environmental forcings by imaging stress cycles from dense acoustic arrays (CRACK THE ROCK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2496170.0
EU funding (EUR): 2496170.0
Participants: 3
Project status: SIGNED

The general idea that a rock mass cracks when the external stress-loading exceeds the rock strength, leading to catastrophic failure (critical cracking), is challenged when considering outcrop erosion. Many observations in the field and the laboratory evidence slow, incremental crack developments well below the yield stress of the material, for which repetitive stress load and fatigue induce progressive failure, also called sub-critical cracking. It is largely accepted that the weather (temperature changes, rain, frost) is a major source of stress cycles and slow cumulative damage, but the literature shows too limited quantitative field observations to confirm the mechanics behind rock outcrop cracking. Today, we cannot predict rockfalls nor quantify the relation between daily or seasonal weather forcings to rock crack production. And yet, rock fracturing plays a leading role in most surface processes, from landscape building to vegetation, hydrology and natural hazard prediction. There is an urgent need to reveal the mechanics of sub-critical failure within rock outcrops. Fracturing processes initiate and develop at small scales (from the grain size to a few mm), and meteorological forcing evolve over daily to seasonal time scales, but existing field observation tools hardly meet these scales. In order to lift this issue, the project will deploy an original active multisensory acoustic imaging technique on natural rock outcrops, to map and monitor stress changes and crack production (in m2/m3/time) over timescales ranging from a few hours to a few months, with a centimetric spatial resolution and a stress sensitivity down to a few kPa. Stress will be deduced from acoustic waves, thanks to the acousto-elasticity principle, allowing us to determine the physics of sub-critical cracking of rock outcrops in their natural environment. This work will pave the way for predicting rockfalls and, further, the impact of climate change on rock erosion.

Keywords: rock mechanics,acoustics,erosion processes,fatigue,cracking,rock weathering,geomorphology
Deciphering Intents of Air traffic controllers, workLOad assessment and Gaze analysis to enable their efficient and trustworthy collaboration with AI (DIALOG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Norway,Italy,France,Netherlands,Germany
Call: ATM application-oriented research for Artificial Intelligence (AI) for aviation (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 1974387.5
EU funding (EUR): 1974387.5
Participants: 6
Project status: SIGNED

The DIALOG project aims to improve collaboration between air traffic controllers (ATCOs) and artificial intelligence (AI) systems in air traffic management. It addresses a very ambitious goal of enabling AI members of human-AI teams to anticipate when and what kind of assistance their human teammates need and to respond on that. DIALOG will develop an AI-based digital assistant called Teamwork Assistant that uses speech recognition and understanding of pilot-controller exchanges to infer ATCOs' intent and goals. It also utilizes machine learning-based methods to assess ATCOs' workload and attention in real-time based on voice, physiology, and behavioral data. The actions of the digital assistant are determined based on the ATCOs' current state, attention allocation, traffic situation, and general context. The project will develop prototypes and conduct validation exercises in close collaboration with end-users to assess the performance and usability of the proposed solutions.

Keywords: artificial intelligence,human ai teaming,workload,speech recognition
Counterfactual Assessment and Valuation for Awareness Architecture (CAVAA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Greece,Germany,France,Spain,United Kingdom,Netherlands,Sweden
Call: Awareness Inside (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3132460.0
EU funding (EUR): 3132460.0
Participants: 12
Project status: SIGNED

The Counterfactual Assessment and Valuation for Awareness Architecture (CAVAA) project proposes that awareness serves survival in a world governed by hidden states, to deal with the “invisible”, from unexplored environments to social interaction that depends on the internal states of agents and moral norms. Awareness reflects a virtual world, a hybrid of perceptual evidence, memory states, and inferred “unobservables”, extended in space and time. The CAVAA project will realize a theory of awareness instantiated as an integrated computational architecture and its components to explain awareness in biological systems and engineer it in technological ones. It will realize underlying computational components of perception, memory, virtualization, simulation, and integration, embody the architecture in robots and artificial agents, validate it across a range of use-cases involving the interaction between multiple humans and artificial agents, using accepted measures and behavioural correlates of awareness. Use cases will address robot foraging, social robotics, computer game benchmarks and human-generated decision trees in a health coach. These benchmarks will focus on resolving trade-offs, e.g. between search efficiency and robustness, and assess the acceptance of human users of aware technology. CAVAA’s awareness engineering is accompanied by an ethics framework towards human users and aware artefacts in the broader spectrum of trustworthy AI, considering shared ontologies, intention complementarity, and behavioural matching, an empathy, relevance of outcomes, reciprocity, counterfactuals and projections towards new future scenarios, and to predict the impact of choices. CAVAA will deliver a better user experience because of its explainability, adaptability, and legibility. CAVAA’s integrated framework redefines how we look at the relationship between humans, other species and smart technologies because it makes the invisible visible.

Keywords: awareness architecture,virtualization,artificial intelligence,embodied cognition,neural computation,cognitive architecture,prospection,empathy,privacy,human robot interaction