Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Photoelectrochemical CO2 Reduction Enhanced by Device Integration and Computational Techniques (PREDICT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: United Kingdom,Italy,Iceland,Greece,Belgium
Call: Solar-to-X devices for the decentralized prosumption of renewable fuels, chemicals and materials as climate change mitigation pathway (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 4233502.4
EU funding (EUR): 3994676.15
Participants: 7
Project status: SIGNED

Motivated by the adverse environmental and societal effects of fossil resources (global warming, pollution, loss of habitat due to mining, health issues), efforts to defossilize the energy, mobility and chemical industries have sought alternatives based on, among others, solar power. Solar-to-X technologies have therefore emerged as promising, since they integrate the energy and chemical conversion steps within a single device, thereby being in principle able to reach high efficiencies, while also having the potential to be deployed in a decentralized manner. Yet, developing such technologies and designing pertinent devices is challenging due to the complex, multiscale nature of the phenomena underpinning their function. Thus motivated, PREDICT aims to elucidate fundamental mechanisms underlying the performance of photo(electro)chemical (PEC) CO2 reduction devices using advanced computational materials science and multiscale modeling techniques. By advancing quantum chemistry approaches for calculating excited state structures and dynamics, as well as bridging electronic, atomistic, mesoscopic, and macroscopic scales, this project will deliver a transferable theoretical and computational framework for the simulation of PEC devices, such as artificial leaves and beyond. The PREDICT modeling framework will be demonstrated via theoretical explorations of novel materials and processes for PEC CO2 reduction, enabling the fundamental understanding of phenomena crucial to the performance of PEC devices, and providing guidelines for optimizing the design to achieve superior performance. The framework and models will be further validated through collaborations with successful experimental projects from Area 1 of the call. Expected outcomes encompass improved device architectures, optimized materials properties, as well as a holistic and transferable multiscale modeling framework, driving the next generation of high-efficiency, integrated solar-to-X devices.

Keywords: solar to x,co2 reduction,quantum mechanics,kinetic monte carlo,computational fluid dynamics,multiscale modeling,device integration
Nanomedicine based approaches for the treatement and diagnsotic of different Lung diseases (LungCare)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Austria,Türkiye,Argentina,Ukraine
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 1197971.43
EU funding (EUR): 1044200.0
Participants: 11
Project status: SIGNED

Nanotechnology concepts have integrated into almost all aspects of current research and the present research area is recognised to be one of nanoscience. Nanomaterials are promising materials to develop new technologies in every branch of science and technology. This is also true when it comes to the biomedical field, where nanotechnology in the form of nanomedicine has a great potential to overcome some of the current limitations using conventional analytical and therapeutic approaches. The focal point of the LungCare project is to turn nanotechnological potentials into tangible outcomes with benefits for patients and the society at large. The philosophy behind LungCare is to provide improvement to the treatment of Pseudomonas aeruginosa (PA) infections via nanovaccines and inhalable therapeutics. It focuses also on the pending question for early and accurate diagnostics of tuberculosis (TB) and lung cancer via the development of sensitive point of care testing devices. In case of lung cancer, sensor development will be accompanied by quantitative image analysis to increase diagnostic accuracy and improve our understanding of the disease characteristics. The LungCare project aims at training of the next generation of students in this rapidly advancing field at the interface between chemistry-physics-biology-medicine and to up-date and improve the know-how of senior researchers and PIs in important parts of nanomedicine such as clinical assay development, state-of the art of organoid developments to limit in vivo testing via and the implementation of artificial intelligent in diagnostics. The different intersectoral secondments to 2 European countries (France, Austria), 2 associated countries (Turkey, Ukraine) and one associated partner (Argentina) will strengthen nanomedicine on the EU level, will encourage knowledge gain and will insure preserving high level research activities under the EU umbrella.

Keywords: nanomedicine pseudomonas infections,tuberculoses,lung cancer,field effect transistores,plasmonics,lung imaging,
Science, technology and research for ethical engagement translate in society (STREETS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-21
End date: 2024-05-20
Duration (months): 24.0
Total project cost (EUR): 323214.29
EU funding (EUR): 299375.0
Participants: 8
Project status: CLOSED

The project S.T.R.E.E.T.S. (Science, Technology and Research for Ethical Engagement Translated in Society) wants to define the new maps of society and science, in order to orient themselves in the places they live to explore the future in the best way, to have a greater and better development. S.T.R.E.E.T.S. project aims to involve the entire Campania region and southern Lazio. With about 7 million inhabitants and with 5 involved public universities (Università di Napoli Federico II, Università di Salerno, Università della Campania L. Vanvitelli, Università L'Orientale, Università di Cassino e del Lazio Meridionale - with the support of Università del Sannio as associated partner - and a network of 24 CNR Institutes, having a total of about 8.000 permanent researchers) S.T.R.E.E.T.S. project aims to bring the population, public administrations, schools, enterprises and other parts of society closer to the research world and viceversa: not just for one night, but starting from the European Research Night. The two main objectives the project wants to reach are: • to allow the scientists to interact directly with the public, tell their own stories, show who they are and what is their role in society, providing them the right tools to do so; • to show the role of the researcher for the society and economy, as well as the impact of researchers’ work on citizens’ daily lives; The activities of the project will combine education with entertainment (edutainment) in various forms, such as exhibitions, hands-on experiments, science shows, simulations, debates, games, competitions, quizzes to encourage formal and informal science education with the aim of improving the scientific knowledge base of the public. . Given so, the impacts that we intend to achieve are: • Enhance engagement with citizens on R&I; • Increase awareness among the general public of the importance and benefits of R&I and its concrete impact on citizens’ daily life; • Contribute to the diffusion and the promotion of excellence research projects across Europe and beyond; • Raise the interest of young people in science and research careers. Finally, in periods of conflict such as these, mitigating "ignorance" can help strengthen a spirit of peace between cultures.

Keywords: public engagement citizen science science for sustainability technology and people research for the future participatory science outreach,collaboration,and dissemination
Solidification of Peritectic Alloys: a Computational Exploration (SPACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

Advanced metallic alloys produced from recycled scrap can significantly reduce emissions, waste, and energy consumption. However, technological alloys with extreme chemical complexities impede the development of high-performance sustainable alloys. Microstructure-oriented alloy design opens promising avenues to guide the development of sustainable (i.e. leaner and less complex) alloys via tailoring the desired microstructure during solidification. Yet, while the development of dendritic and eutectic microstructures is relatively well understood, the comprehension of growth mechanisms of peritectic solidification (common to a broad range of alloy families) remains incomplete. The SPACE project will develop a quantitative phase-field model to investigate the emergence of complex growth patterns during peritectic solidification. To do so, we will (i) develop a quantitative multi-phase and multi-component nondiagonal phase field (MP-MC-NPF) model based on Onsager's relation, (ii) validate the model against sharp interface calculations and experimental observations, (iii) explore three-dimensional peritectic growth mechanisms at experimentally- relevant length and time scales (via GPU code acceleration), and (iv) study the effect of minor element addition (e.g. impurities from recycling) on microstructure growth and selection. We will focus, primarily, on binary Fe-Ni and ternary Fe-Ni-X alloys with high impact potential. The resulting MP-MC-NPF framework will shed light on the fundamental mechanisms of complex growth patterns and morphology transitions during peritectic solidification (for the first time in three dimensions and transient conditions) and thus contribute to the transition toward microstructure-oriented design of impurity-tolerant sustainable alloys.

Keywords: sustainable steels solidification processing phase field modeling computational thermodynamics and kinetics peritectic transformation
States’ Practice of Human Rights Justification: a study in civil society engagement and human rights through the lens of gender and intersectionality (HRJust)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Sweden,Netherlands,India,Switzerland,Taiwan, Province of China,Italy,Israel,Czechia,Finland
Call: Global governance for a world in transition: Norms, institutions, actors (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2998485.99
EU funding (EUR): 2998485.99
Participants: 17
Project status: SIGNED

Human Rights Justifications (HRJ) are when States use human rights to justify decisions. Human rights regimes operate on the presumptions that only individual persons can be in possession of human rights. The regulatory gaps occurring when the States use HRJ for their actions are two-fold, one in the regulation of the States’ use of HRJ and one in the individual human rights protection when States use HRJ. This activity is not regulated by any international, regional or national regime. In other words, significant and important gaps in human rights regulations has now been identified, which this project seeks to address. We will develop a theory of HRJ and a process for Systematic Ongoing Civil Society Engagement (ODCSE) as a tool for a gender and intersectional inclusive Civil Society engagement. Through ODCSE, we will identify gaps in human rights regulations and protection, serving as underpinning data for our recommendations to EU in support of a multinational human rights system and promotion of transnational democratic governance. ODCSE will also help us identify geopolitical elements that influence States’ use of HRJ. This will be done through 5 countries: Sweden, Finland, Taiwan, India and Ukraine, through three actions: human rights dialogue, inclusive democratic participations, and protection of human rights defenders, and operationalised through three themes: Covid, Migration and Climate.

Keywords: human rights,democracy,civil engagement,gender,intersectionality,multilateralism,democratic safeguards,accountability,transparency
Precision Human Organs-on-chip for Enhanced Neuro-muscular and Cardiac Studies – Safety Evaluation (PHOENIX-SE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Serbia
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 36.0
Total project cost (EUR): 599347.5
EU funding (EUR): 599347.5
Participants: 2
Project status: CLOSED

PHOENIX-SE is a Hop-On action to the Horizon Europe PHOENIX project, which develops next-generation organs-on-chip (OoC) platforms to reduce animal use and accelerate safer drug development. It introduces µSafeHeart, a simplified cardiac safety platform based on screen-printed multielectrode arrays in standard multiwell plates. Delivered as a plug-and-play module fully interoperable with existing PHOENIX systems, it provides a cost-effective solution for stimulation, field-potential and impedance sensing for routine preclinical screening. µSafeHeart integrates into current PHOENIX workflows without hardware modifications at partner sites. TECNALIA Serbia (TECSR) will join the consortium to bring excellence in printed electronics design, prototyping and pilot production. We will also assess nearshore manufacturing of selected PHOENIX components in Serbia to strengthen EU sourcing and supply-chain resilience. The action includes targeted dissemination and capacity-building to support uptake in Widening countries. Expected outcomes are a validated µSafeHeart plate, seamless PHOENIX integration, a pilot manufacturing route with reduced unit costs, and early adoption by pharmaceutical companies and contract research organizations (CROs).

Keywords: printed electronics,scale up,organ on chip
Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding (DynaHear)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499411.25
EU funding (EUR): 2499411.0
Participants: 1
Project status: SIGNED

Our sense of hearing processes stimuli that differ in sound pressure by more than six orders of magnitude. Yet, while the presynaptic inner hair cells (IHCs) cover this wide dynamic range, each postsynaptic spiral ganglion neuron (SGN) encodes only a fraction and the intensity information is then reconstructed by the brain. This so-called “dynamic range problem” of hearing is known for decades, but how sound intensity information is decomposed into different neural pathways remains elusive. In vivo recordings report major functional SGN diversity and ensembles of such diverse neurons collectively encode intensity for a given sound frequency. Recently, a major heterogeneity of afferent SGN synapses with IHCs as well as different molecular SGN profiles have been discovered. How these relate to the diverse sound coding properties of SGNs remains to be elucidated. DynaHear sets out to close this gap by testing the hypothesis that an interplay of synaptic heterogeneity, molecularly distinct subtypes of SGNs, and efferent modulation serves the neural decomposition of sound intensity information. This is enabled by innovative approaches to cochlear structure and function, some of which we have recently established, while others will be developed in DynaHear. We will combine electrophysiology, optogenetics, molecular labelling and tracing, multiscale and multimodal imaging, with computational modeling. We will elucidate the molecular underpinnings of afferent synaptic heterogeneity, decipher mechanisms establishing such heterogeneity, and relate them to functional SGN diversity. DynaHear promises to fundamentally advance our understanding of sound intensity coding and contribute to solving the dynamic range problem of sound encoding. Moreover, the proposed work will help to better understand synaptic hearing impairment, assist current hearing rehabilitation, and pave the way for innovative therapeutic approaches such as gene therapy and optogenetic restoration of hearing.

Keywords: hearing,synapses,sensory coding,inner ear,deafness,hearing restoration,physiology,anatomy,genetics
Surveillance of Translation: From Molecular Mechanisms to Roles in Disease (SuTra)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499925.0
EU funding (EUR): 2499925.0
Participants: 1
Project status: SIGNED

Proteostasis is a dynamic network integrating protein biogenesis, folding, trafficking, and degradation to build a functional proteome. Disrupted proteostasis resulting the accumulation and aggregation of aberrant proteins in neurons is a hallmark of neurodegenerative diseases. This project’s overall goal is to uncover molecular mechanisms that maintain proteostasis and protect against neurodegeneration, by taking a fresh look at these processes through the lens of Ribosome-associated Quality Control (RQC), a fundamental translational surveillance mechanism whose defect causes neurodegeneration. RQC targets incomplete proteins produced by stalled ribosomes for proteolysis through two pathways mediated by factors associated with the large (60S) subunit: the E3 ubiquitin ligase, Listerin/Ltn1, and NEMF, which tags the nascent-chains with polyAla-tails that act as degrons sensed by other E3 ligases. Our preliminary data uncover that Ala-tailing modifies neurodegeneration in Ltn1-mutant mice: while Ala-tailing provides initial protection against loss of Ltn1 function, Ala-tailed proteins that evade degradation eventually accumulate and aggregate, contributing to the disease. We will create mammalian cell models, develop methods to study endogenous RQC, and use state-of-the-art biochemical and functional approaches, to: elucidate how Ala-tailed protein accumulation contributes to cellular dysfunction and toxicity (Aim 1), investigate the role of RQC in proteostasis dysfunction and cytotoxicity caused by disease-associated gene mutations (Aim 2), and uncover novel factors that sense ribosomal stalling (Aim 3). The results will lay the foundation for understanding how defects in RQC cause neuronal dysfunction, whether RQC plays a broader role in human disease, and why neurons are especially susceptible to RQC defects. These insights will provide critical molecular understanding of proteostasis and disease, which is essential for developing new target-based therapies.

Keywords: proteostasis,ubiquitin,rqc,translational surveillance
Holographic Optical Tweezing Bioprinting (HOTB): Towards precise manipulation of cells for artificial multi-scaled vascularized tissues/organ printing. (HOT-BIOPRINTING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1965525.0
EU funding (EUR): 1965525.0
Participants: 1
Project status: SIGNED

Because current limitations in 3D bioprinting for tissue engineering stem from the fact that the multi-scaled vasculature associated to the human microtissues and organs cannot be replicated. The overarching aim of the HOT-BIOPRINTING project is to deliver a methodology enabling the manufacturing of a new generation of tissue-like structures with properties mimicking more closely the complexity of biological tissues and organs. The innovation of HOT-BIOPRINTING lies on the development of a disruptive technology named Holographic optical tweezing bioprinting (HOTB) for single and automatized multiple cell 3D bioprinting. The non-contact nature of light will eliminate the fails on bioprinting associated to instrumentation, which along with the HOTB capabilities for manipulating single cells for printing will drive a new paradigm shift: “resolution will be dictated by the cell size instead of by the mechanical component of the instrumentation”. This new technological advancement for resolution enhancement while maintaining bioprinting speed using holographic automatization can open new opportunities to the tissue engineering and regenerative medicine community. I propose the following general objectives that go beyond the state of the art in bioprinting human mimetic tissue: 1) Generate the knowledge and develop a Holographic Optical tweezer bioprinter (HOTB) for high-definition single/multiple cell bioprinting. 2) Demonstration and automatization for 3D multicellular printing for large area tissue generation. 3) Overcome the challenges associated with existing biofabrication techniques (limited multi-scaled vascularization and oversimplified structures). 4) Demonstrating lymph-node bioprinting with integrated vasculature. This represents a big challenge, if achieved, will revolutionize the bioprint technology by increasing the tissue complexity and by responding to the demand of biofabricating multi-scale vascularized complex tissues and organs.

Keywords: 3d bioprinting,tissue and organ engineering,holographic optical tweezing bioprinting,multi scaled vasculaturized tissue bioprinting,appling photonics concepts to bioprinting,holographic shaping light for bioprinting