Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic crosstalk in the regulation of inflammation (Metabinnate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Ireland
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 2484858.0
EU funding (EUR): 2484858.0
Participants: 1
Project status: SIGNED

The study of the molecular basis to the immune response has for decades concerned receptors and the signalling pathways they activate which lead to immune cell activation. Recently metabolic changes have also been shown to couple to immune effector responses. A shift in appreciation of the role of metabolites beyond energy metabolism and biosynthetic processes has emerged. We have been examining the role of three metabolites in macrophages. We have evidence that two of these, malonyl-CoA and 2-hydroxyglutarate (2-HG) are pro-inflammatory, whilst the third, itaconate, has profound anti-inflammatory effects. In many ways, they mirror cytokines, with malonyl-CoA and 2-HG being akin to pro-inflammatory cytokines, whilst itaconate resembles anti-inflammatory cytokines. The specificity and breadth of the role of these metabolites in macrophages will be mapped in this proposal. For malonyl-CoA we have evidence that it regulates GAPDH, IRG1/CAD (which synthesises itaconate) and the key cytokine IL-1beta. For 2-HG, we will examine the production and actions of its 2 enantiomers, D-2-HG and L-2-HG, focusing on their effect on HIF1alpha and epigenetic regulation. For itaconate we have evidence for a role in Type I interferon modulation, antigen presentation, inflammasome regulation and GAPDH and LDHA (which can produce 2-HG) activities. We also have evidence that OXGR1 is the receptor for itaconate. All of these aspects will be explored in detail. Critically we will also determine the relationship between these metabolites since we have evidence for cross-talk. Their dynamic regulation is likely to be a key aspect of how metabolic reprogramming controls macrophage function. Our studies point to a major shift in our understanding of how intracellular metabolic changes lead to inflammation. The overall aim is therefore to elucidate how metabolic reprogramming controls inflammatory macrophage activation, which may lead to new therapeutic targets for inflammatory diseases.

Keywords: immunometabolism,metabolic reprogamming,macrophages
Increasing disaster Resilience by establishing a sustainable process to support Standardisation of technologies and services (ResiStand)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Spain,Finland,Norway,Netherlands,Netherlands,United Kingdom
Call: Crisis management topic 6: Addressing standardisation opportunities in support of increasing disaster resilience (H2020-DRS-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 1962553.75
EU funding (EUR): 1962553.75
Participants: 15
Project status: CLOSED

Standardisation is a powerful tool to achieve better interoperability. However, it needs to overcome a lack of interest and modest participation from stakeholders. Also, promising research results are not always used as the basis for new standards. The overall goal of ResiStand is to find new ways to improve the crisis management and disaster resilience capabilities of the European Union and individual Member States through standardisation. ResiStand contributes to an improved disaster resilience by identifying and analysing the drivers, constraints and expectations of three main stakeholder communities: Standardisation Organisations, End-Users and Suppliers, consisting of researchers, industry and SMEs. Based on this information, gaps in standardisation are identified and a prioritised roadmap for new initiatives will be created. The roadmap will be complemented by a critical evaluation of standards as a tool to improve disaster resilience. ResiStand aims at implementing a pre-standardisation process that supports the development of standards. The feasibility of the process will be tested by developing a new work item. The aim is that stakeholders will continuously utilize this “ResiStand Process” in the future, and that the project delivers a better understanding of the potential of standards for contributing to an improved disaster resilience. ResiStand will support the management of increasing threats to society such as armed conflicts, terrorism, pandemics and natural disasters, which have increasingly cross-border, even global consequences due to the on-going globalisation. Protection of citizens through anticipation, preparedness, response and adaptation to crisis situations – i.e. maintaining disaster resilience – will be more efficient. Collaboration between national, European and international stakeholders will be improved by unified processes and management systems as well as by technical, procedural, operational and semantic interoperability.

Keywords: standardisation,disaster resilience,harmonisation,interoperability
Collective Awareness PlatformS for Environmentally-sound Land management based on data technoLogies and Agrobiodiversity (CAPSELLA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Belgium,Greece,Czechia,Netherlands,United Kingdom
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-06-30
Duration (months): 30.0
Total project cost (EUR): 2056750.0
EU funding (EUR): 2056750.0
Participants: 8
Project status: CLOSED

A major sustainability challenge for the European society is moving beyond conventional, industrialised food production and agricultural systems, characterised by a high use of external inputs. Mainstream conventional food production systems are posing a serious threat to the environment and to biodiversity and are becoming increasingly unsustainable due to unacceptable levels of food waste in industrialized countries and to shrinking farmers’ incomes. Alternative systems with reduced use of external inputs have to be promoted , based on i) an optimised use of agricultural biodiversity (hereafter ‘agrobiodiversity’), ecological processes and natural resources and on ii) improved food systems based e.g. on short supply chain quality food, where consumers play an active role in driving produce demand and consequently offer. CAPSELLA will address this challenge in two ways: (a) raising awareness on these issues especially within and among local communities (smallholders agriculture, biodiversity, food quality) but also within the broader European public, and (b) offering innovative ICT solutions that will address needs and requirements coming from the communities. To achieve this we will use a combination of participatory bottom up data collection and top down data integration to develop solutions for two domains: agrobiodiversity and local food knowledge. The project aims to (a) build from scratch open data repositories concerning regional agrobiodiversity, and (b) to build upon and enhance existing data sets on the agrobiodiversity and food domains. Based on these, the project will develop a number of community-driven data powered ICT solutions, which will be tested by the communities engaged in the project and will result in a number of pilots. Finally, our project will have a strong societal and business sustainability focus by also including incubation activities for selected pilots.
DEsign of Multifunctional 2D-OrgaNic Hybrids (DEMONH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Because of their reduced dimensionality and symmetry, two-dimensional (2D) materials withstand physical phenomena that are very different from their 3D bulk counterparts. Beside graphene, other members of the same family of materials include metal dichalcogenides (MX2) and hexagonal boron nitride (h-BN). Remarkably, while single-layer graphene is a semimetal, 2D h-BN is an insulator and 2D MoS2 is a direct bandgap semiconductor. A new paradigm in materials science consists in piling up into vertical stacks single sheets of 2D materials with complementary electro-optical characteristics, thereby paving the way to the fabrication of ultrathin and flexible multilayer heterostructure devices. DEMONH aims at designing multilayer architectures based on 2D material building blocks with tunable electronic structure and optical properties that can be prepared by solution processing techniques. Among many others, this approach offers the unique advantage that the electrical and optical characteristics of the elementary 2D units can be tuned over a broad range by functionalization of their surface with properly designed conjugated organic molecules, which: (i) assist in the exfoliation process and stabilize single or multiple layers as suspensions in the liquid phase; and (ii) convey to the resulting hybrid organic-2D materials new or improved functionalities. In particular, the use of light-responsive molecules opens up the possibility to remotely switch on and off charge injection and extraction at interfaces. In DEMONH, we will combine state of the art modeling tools to design multifunctional electro-active conjugated molecules yielding optimized (light-triggered) energy level alignment at interfaces and charge transport properties in stacked 2D layer architectures. Such design strategies require the development of appropriate theoretical models and their coding in efficient software programs, which will be implemented in a multiscale modeling platform.

Keywords: 2d crystals,graphene,theoretical modeling,heterojunctions,charge transport,electronic structure calculations,quantum chemistry,effective hamiltonians,chemical doping,exfoliation
What makes the Danish sound system so difficult for non-native learners? (LxDP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2022-09-02
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Danish is generally believed to be an especially difficult language to acquire for non-native learners. Since research shows that language proficiency plays an important role in both socio-cultural integration and employability of immigrants, the recent influx of immigrants from non-Western countries to Denmark call for more knowledge on the linguistic problems facing non-native learners of Danish. Nevertheless, Danish as a non-native language is hugely understudied. The problems are generally believed to lie primarily in the intricacy of the sound system, especially in the complex phonological processes. Phonologists have argued that Danish phonology is relatively unnatural due to the amount of discrepancy between the underlying abstract representation and the realised surface form of a sound as well as the many-to-many mappings between these two layers of representation. This analysis has led to theoretical predictions regarding the origins of difficulty, which currently have not been tested. The proposed project aims to test these theoretical predictions by investigating the effect of the different types of theoretically predicted difficulty on non-native speech learning. The effect of the different types of difficulty will be tested both in the comprehension direction and the production direction in order to get a thorough understanding of how unnatural aspects of Danish phonology affect non-native speech learning. The project will be the first to approach non-native speech learning of Danish from a laboratory perspective, thereby extending the scientific domain of the field. The outcome of the project provides a stepping stone to improve language teaching materials for non-native learners and better prepare language teachers, which is clearly called for as research shows that language school students find pronunciation the most difficult aspect of the Danish language and report that pronunciation receives the least attention in their Danish classes.

Keywords: phonology,danish as a non native language,speech comprehension,speech production
Precision medicine for muscoloskeletal regeneration, prosthetics and active ageing (PREMUROSA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Italy,Italy,Italy,Serbia,Finland,Finland,Switzerland,Latvia,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-09-30
Duration (months): 57.0
Total project cost (EUR): 3348405.36
EU funding (EUR): 3348405.36
Participants: 11
Project status: SIGNED

Muscoloskeletal diseases are a major burden on individuals, healthcare and welfare systems. Treatment of muscolo-skeletal disorders is currently based either on prosthetic or regenerative surgical procedures, often involving medical device implantation. In both cases, individual tissue healing and regeneration, together with the appropriateness of the implanted device, markedly affect the outcome. A great improvement could be achieved by precision medicine, specifically designed on patient’s individual characteristics. This implies to combine the personalized clinical approach with individual ‘omic’ characterization and proper choice of medical device. The concept is “To take care with care”. This is the meaning of the Italian word “premurosa” and the ultimate goal of the ITN PREMUROSA project, aimed to train a new generation of scientists with an integrated vision of the whole value chain in muscolo-skeletal regeneration technologies and able to boost the necessary innovations to achieve precision principles in developing innovative devices and optimized clinical applications. This aim will be achieved by a “triple i” (interdisciplinary, intersectoral, international) approach of thirteen ESRs, who will benefit from an excellent scientific environment, up-date technologies and supervision by international leaders in the field. They will learn to integrate academic and industrial aspects and they will sharpen their experimental and complementary skills in a well-designed and diversified and unprecedented training program.

Keywords: precision medicine,personalized medicine,muscoloskeletal,regeneration,in vitro 3d model,organoid,bioreactor,microvesicle,3d printing,osteointegration,cartilage,bone,in silico,omic
Enabling motor control after a spinal cord injury through nanoscaled electrical (EPI_nanoSTIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-11-14
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

A spinal cord injury (SCI) has consistent social costs, due to dramatic and disabling consequences and a high incidence on the youngest and most productive population, which can hardly be alleviated by the very few and controversial therapeutic treatments. In a recent case report, epidural electrostimulation combined with an intense training enabled some highly variable conscious motor control of legs in four motor complete spinal cord injured volunteers. The aim of understanding the mechanisms behind these improvements can help define more effective pharmacological and electrical stimulating protocols with breakthrough technology to restore functions after a SCI. Experiments will be performed on adult rats, with an experimental SCI closer to human chronic lesions, on which I will apply the novel enabling protocol with epidural electrostimulation associated with an intense motor training. Outcome will be evaluated with innovative combinations of electromyographic and kinematic assessments of locomotion and standing posture, in vivo terminal intracellular recordings from lumbar motoneurons and histological examination of spared axons across the lesion. Then, I will employ carbon nanotubes to devise nanostructured innovative stimulation arrays for a more specific and focussed epidural stimulation to enhance recovery. The unique experience of Prof. Edgerton and Prof. Ballerini will allow me to acquire new skills on both preclinical SCI models and assessments and nanotechnologies, to increase my international collaborations, support my research through greater funds and a new in vivo research line, with the aims of obtaining a professorship and a greater visibility in the field. The project is deemed to advance and diffuse scientific knowledge and further sustain European competitiveness, through two patents on discoveries with a great commercial impact and possible clinical applications to reduce healthcare expenses.

Keywords: spinal cord injury,motor recovery,neurorehabilitation,activity dependent plasticity,motoneuron,nanotechnology,training,epidural stimulation,pharmacology,carbon nanotubes,contusion injury
PROcesses for Value added fibres by Innovative Deep Eutectic Solvents (PROVIDES)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Austria,Germany,Switzerland,Belgium,Finland,Finland,Sweden,France,France,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Portugal,Portugal,Portugal
Call: New sustainable pulping technologies (H2020-BBI-PPP-2014-1, 2014)
Start date: 2015-07-01
End date: 2018-12-31
Duration (months): 42.0
Total project cost (EUR): 2496343.5
EU funding (EUR): 1079551.0
Participants: 27
Project status: CLOSED

The main objective of the PROVIDES project is to develop a radically new, sustainable and techno-economically feasible pulping technology for wood and agro-based lignocellulose raw materials based on deep eutectic solvents (DES), a new class of natural solvents which have the unique ability to dissolve and thus mildly fractionate lignin, hemicellulose and cellulose at low temperature and atmospheric pressure for further processing into high added value materials and chemicals. The aim is to transfer recent scientific findings in novel lignin dissolving DES to process concept level that can be evaluated against current pulping processes. The technological breakthrough expected through the development of such new DES pulping technology could reduce process energy intensity by at least 40% and investment costs by 50% compared to traditional chemical pulping technology. In parallel, the development of efficient novel cellulose-dissolving DES and other DESs to process lignocellulose materials, starting with paper for recycling, is aimed at with focus on sustainability in selecting DES chemical components and technical and economic applicability of the solvent system. PROVIDES will create both fundamental and industry driven technological knowledge based on lab to bench/pilot scale experimentation, through: mapping and selection of most effective DES families; investigating processes and process technology options, including DES regeneration and recycling, in order to define full industrial processes that would isolate high quality cellulose/fibres, lignin and hemicelluloses; providing products for industrial evaluation; establishing technical data to evaluate industrial feasibility and integration; performing life-cycle oriented assessment of environmental and socio-economic performance; assessing impacts in terms of energy and cost reductions as well as new high added value applications PROVIDES could provide to the pulp and paper industry sector.

Keywords: pulping,energy efficiency,cellulose,lignin,hemicellulose,deep eutectic solvents,fibres