Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sugarcoating matters: Deciphering the effects of aberrant receptor N-glycosylation on oncogenesis and drug resistance in acute myeloid leukemia (Sugarcoating matters)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

During my post-doctoral studies, I have shown that sugarcoating of proteins, “N-glycosylation” specifically, is essential for the development and a potential therapeutic target in the blood cancer myeloproliferative neoplasms. Here, I show that differential expression of three enzymes that are key to protein sugar coating are strong novel prognostic factors in the blood cancer acute myeloid leukemia (AML). Specifically, these enzymes remove or add glucose molecules of the N-glycan sugar tree. Removal of the outer glucoses is essential for retaining N-glycoproteins within the endoplasmic reticulum (ER) and unprocessed N-glycans contain a high number of mannose sugars. I hypothesize that unprocessed N-glycoproteins such as growth receptors and drug removal pumps escape the ER and are expressed on the cell surface at a higher level due to abnormal expression of genes implicated in sugar coating (ALG10B, MOGS and PRKCSH). This in turn contributes to AML development and poor outcome. To proof my hypothesis, I will decipher the role of key enzymes in N-glycan glucose addition and removal to myeloid oncogenesis (aim 1A) and drug resistance (aim 1B) using colony forming unit assays and cell lines that express ALG10B or lack MOGS/PRKCSH (CRISPR-Cas9 knockout). Additionally, I will assess mannose abundance and targetability on primary AML versus healthy control bone marrow samples (aim 2A), and map N-glycan structures using recently developed high-throughput mass spectrometry and analyses techniques (aim 2B). I will correlate structural N-glycan profiles with expression of N-glycan processing enzymes assessed through RNA-sequencing to create a full picture of N-glycosylation aberrancies in AML. This study will decipher the molecular mechanisms underlying aberrant N-glycosylation in AML and provide anchor points for novel AML therapies. This is important, because the current 5-year overall survival rate of AML is only ~30% so therapy improvements are highly warranted.

Keywords: glycobiology
Pre-clinical validation of a novel gene therapy for a rare disease in non-human primates: Integrative approach to the CMC scale-up process validation of a gene therapy product for Friedreich Ataxia (FRATAXAV)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Founded in 2018, Biointaxis is an academic spin-off company established by a team of researchers lead by a woman Scientist from the Research Institute Germans Trias i Pujol (IGTP) benefiting from extensive know-how in the identification of genes, biomarkers and translational mechanisms underlying neurodegenerative disorders. Our leading candidate, BTX-101, is currently the best-in-class product for the treatment of Friedreich’s Ataxia (FRDA), a rare devastating inherited, progressive, neurodegenerative disease typically affecting teenagers and young adults for whom there are no treatments. Our product proves treatment efficacy being able to re-establish the neurological and cardiac functions in two FRDA mice models. The product is patented (WO2019076973A1) becoming the first preclinical product ever to show life-long disease modifying activity both for neurological and cardiac symptoms in FRDA. Biointaxis has a unique know-how, based on years of fundamental research which has resulted in strong collaborations from important research centers including the Research Institute Germans Trias i Pujol (IGTP) affiliated to the Universitat Autònoma de Barcelona, top University in Spain; reference public Hospitals (University Hospital Germans Trias i Pujol in Badalona, The Virgen del Rocío University Hospital in Seville, Valdecilla University Hospital in Cantabria); public administration (Biocat - la Fundació BioRegió de Catalunya) and foundations (La Caixa, Federación de Ataxias de España, EuroAtaxia, STOP_Friedreich Ataxia), etc. BTX-101 has already been capable of attracting investment to Biointaxis with a €1M seed round in 2022. After sound pre-clinical and clinical validation completed in the next three years, BTX-101 will become also capable of attracting more interest from pharma customers for further validation and commercialization. Ultimately, Biointaxis aims to change the paradigm in Friedreich's ataxia and to defeat rare diseases to restore patient's health.

Keywords: advanced therapies,rare diseases,friedreich s ataxia
Agricultural Robotics and Augmented Reality for Workplace Enhancement and Labor Linkage (AGRO-WELL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Greece,Cyprus,Netherlands,France,North Macedonia
Call: Enhancing working conditions and strengthening the work force through digital and data technologies – the potential of robotics and augmented reality in agriculture (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 4998670.0
EU funding (EUR): 4998670.0
Participants: 13
Project status: SIGNED

The agricultural sector is known for its demanding and hazardous working environments, leading to high rates of accidents and health issues among workers. Furthermore, drudgery due to physical work and repetitive tasks diminishes the attractiveness of the sector for youth. Emerging challenges such as digitalisation, technological intensification, structural change, environmental targets, and new risks due to climate change, coupled with global economic implications demand more and more from farmers and farm workers, exacerbate the need for timely information, and have new implications for occupational safety and health (OSH). AGRO-WELL follows a highly interdisciplinary approach to enhance knowledge for technological transitions towards an environmentally, economically, and socially sustainable agricultural sector. It brings together leading scientists from a multitude of OSH-related disciplines, various regions across Europe, key technology providers and farmer representatives. The project will assess farmer needs and explore ways to increase awareness with respect to smart farming. AGRO-WELL builds on five technologies to leverage the potential of robotics, augmented reality, and artificial intelligence to enhance working conditions and farm safety, enable faster and better-informed farm management decisions, and reduce the environmental impact of four different farming systems. Potential effects of the technologies will be multidimensionally assessed. To support market uptake, AGRO-WELL will design and explore the viability of business models based on novel technologies that are predominantly focused on improving OSH. To support other promising technologies, AGRO-WELL will incorporate an open technology competition enabled by cascade funding. All project results will be synthesized in effective dissemination strategies and meaningful policy recommendations to foster promising technological solutions and sustainable business models.

Keywords: digitalisation,ai,augmented reality,agro robotics,smart farming,sustainability,working conditions
Mesopotamian Orality and the Anthropology of Writing (MesOr)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2030-09-30
Duration (months): 69.0
Total project cost (EUR): 2499793.0
EU funding (EUR): 2499793.0
Participants: 1
Project status: SIGNED

This project seeks to understand the interplay between writing and orality in Ancient Mesopotamia (c. 3400 BCE – AD 100): what was written down, what circulated only in the oral realm, aThis project seeks to understand the interplay between writing and orality in Ancient Mesopotamia (c. 3400 BCE – AD 100): what was written down, what circulated only in the oral realm, and why. The result will be a cohesive model of orality and writing in Ancient Mesopotamia, which will in turn shed light on ancient societies with less documentation, enabling a much-needed ‘leap forward’ in the study of ancient writing and orality beyond Mesopotamia alone. It will also open up a new sub-field within Mesopotamian studies, and offer new ways of thinking about Mesopotamian writings. MESOR’s goals will be met by three work packages. First, it aims to establish the facts about what sort of things were usually written down, and what sort of things were not; and about how this varied across time, place, context, and type of written document. Secondly, the project aims to interpret and explain the distribution which it identified. To take some simple examples: Why are there no cuneiform graffiti? Why do cuneiform sources hardly mention begging? What did and did not get embraced by the ‘written tradition’? The project will be the first time such questions are addressed in an organic and systematic way. Use will be made of wide-ranging ethnographic parallels. Thirdly, the project will work out the implications and applications of its findings. These extend across all aspects of the lived experience, from administration to education to religion. The project’s methods will unite traditional close reading with corpus-driven quantitative data analysis, and its investigation will transcend established disciplinary boundaries: it will combine Akkadian and Sumerian philology, the anthropology of reading and writing, the history of literacy studies, orality studies, and socio-cultural history.

Keywords: anthropology of writing history of writing orality anthropology of orality history of orality anthropology of literacy mesopotamian studies assyriology
REDUCING BYCATCH OF THREATENED MEGAFAUNA IN THE EAST CENTRAL ATLANTIC (REDUCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Spain,Portugal,United Kingdom,France,Senegal
Call: Understanding and reducing bycatch of protected species (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 8156593.75
EU funding (EUR): 8156593.75
Participants: 13
Project status: SIGNED

REDUCE will unify stakeholder efforts and utilize an interdisciplinary scientific approach to reduce bycatch of marine megafauna and inform sustainable fishery management in the Eastern Central Atlantic Ocean. The diagnosis and integration of bycatch data across all industrial European fleets in the region, linked with fishing effort and the spatiotemporal distribution of the species, will provide a systematic approach to jointly assess and tackle policy challenges. The expansion and improvement of the observer programmes and the advances in electronic monitoring and automated machine learning systems will enable species-specific and high-resolution data of marine megafauna bycatch. Fine-scale GPS tracking of selected species combined with AIS fishery data in concurrent time will allow understanding key drivers of interactions and infer political responsibilities. New fine-scale tracking data of carefully selected species in the region will allow for a better understanding of their abundance and distribution and post-release mortality. Sightings, fishery catches and tracking data on marine megafauna will be combined to provide a step-changes in predictive habitat mapping approaches to understand overlap and bycatch risk from local to basin-scales. The combination of timeseries of sightings, fishery catches, GPS and GLS tracking and capture-mark-recapture studies, will provide an unprecedented view on megafauna hotspots and the risks and impacts of bycatch, boosting marine spatial planning or pelagic waters. Assessment and testing of mitigation measures will identify key approaches to significantly reduce bycatch in the region. Innovative and efficient data handling, sharing and publishing will establish an integrated approach to the bycatch data community. Capacity and cooperation between science, fishery industry and policymakers bordering Eastern Central Atlantic Ocean will be boosted by joint multi-disciplinary workshops, scientific training and monitoring events
Aerial Drone-based Automated Tree Harvesting System for Sustainable Forestry (ADATHA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Forest thinning is vital to maintain forest health and productivity and prevent wildfires. The global €50B tree-handling industry relies on inefficient old technology. 15-30 t machines cut through the forest, severely damaging the forest floor and ecosystem, emitting a total of 10M t of CO2 by burning diesel, and felling healthy trees to make access roads (affecting ~20% of the forest ecosystem). AirForestry is reinventing forestry by enabling the fossil-free harvesting of trees from the air. Our solution is a novel combination of a drone and a lightweight wood harvesting tool for grabbing, delimbing and cutting selected trees. We use an electric multi-copter with AI-based visual navigation to locate specific trees (sick, alien, wildfire-vulnerable), cut them and deliver timber to the roadside. Our innovation will disrupt the tree-thinning market by offering an automated, non-invasive, and sustainable alternative to harmful state-of-the-art methods.

Keywords: drones,robotics,timber harvesting,sustainable forestry,carbon sequestration,green technologies,automation and control systems
TMA tackle the inefficiencies that plague the gas and chemical industry by digitizing their operations, inventory, and supply chain, thanks to an IOT-enabled, machine learning optimization software. (TMA Digitization)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 20.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 1
Project status: SIGNED

TMA tackles the inefficiencies that plague the gas and chemical industry by digitizing their operations, inventory, and supply chain, thanks to an IOT-enabled, machine learning optimization software. Our mission is to leverage AIoT technology to optimize the operations of primary industries, minimize their inventory and distribution waste, and maximize their profitability. Currently, this market and industry is untargeted due to both their complex, highly regulated environments, and the lack of comprehensive and harmonized, all-inclusive solutions available for the industry today. Our vision is to enable a world powered by safer, more sustainable, and accessible energy and manufacturing solutions. Thanks to advanced, state-of-the art and scalable AIoT solutions, combining affordable ATEX-compliant tracking with advanced machine-learning algorithms and web applications for inventory optimization, we aim to obtain a market of €10 billion with the next 5 years, servicing gas cylinder distributors (first specializing in the 2 billion LPG gas and then expending to specialty-gases, including hydrogen, oxygen and argon) and chemical distributors. This would then give us an entry door to these distributors’ target markets, including 96% of high value manufacturing sectors, including pharma, electronics and automotive. We mostly aim to bring a significant sustainable impact, by creating safer primary and manufacturing industries (reducing gas explosions, chemical spillages and hurtful workloads), more efficient distribution schedules (15% reduced transportation and 20% gas wastage) and more accessible and affordable energy solutions for over 2 billion people.

Keywords: digitization
Intravascular near-infrared fluorescence and ultrasound coronary imaging (NIRFUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Greece,United Kingdom,France,Spain
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 2995830.0
EU funding (EUR): 2995830.0
Participants: 5
Project status: SIGNED

NIRFUS will address the documented need of complementing morphology markers with patho-biological information during intravascular imaging. To enable molecular readings and achieve a breakthrough in interventional cardiology, NIRFUS will implement a new ability in medical micro-optics and address critical obstacles in catheter manufacturing and assembly precision. NIRFUS develops novel concepts and abilities in medical micro-optics by exploring advanced approaches for fabricating and aligning optical components, from basic principles to proof of concept and laboratory validation. These novel methods will enable for the first time the development of clinical-grade near-infrared fluorescence (NIRF) readings added to intravascular ultrasound (IVUS), based on hybrid NIRF-IVUS catheters of unprecedented performance and reliability suitable for human use. NIRFUS will further add complimentary sensing modalities to deliver the most quantitative intravascular NIRF performance ever achieved. The advances in precision engineering, and optical integration, NIRFUS will lead to a new standard of medical micro-optics. Likewise, the hybrid NIRF-IVUS catheter will lead to a new standard in interventional imaging and cardiology. NIRFUS may benefit 3 million people who undergo percutaneous coronary intervention (PCI) annually by radically improving treatment and clinical outcomes, as well as the efficiency and cost-effectiveness of the global interventional cardiology healthcare, with estimated cost savings of more than € 3.6 billion.

Keywords: optoacoustics,intravascular catheter,microfabrication,interventional cardiology,coronary imaging
A Non-invasive, Touch-Free In-Line Viscosity System for Flow Visualization to Reduce Waste, Reworks, and Optimize Production Efficiency. (INCIFLOW)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The industrial sector, a vital part of the global economy, continually battles with unplanned shutdowns & breakdowns, leading to financial losses, operational inefficiencies, & heightened safety risks. Traditional monitoring methods, dependent on sporadic lab sampling & manual measurements, often miss early detection of issues, resulting in off-spec products, productivity losses, & significant quality variations. Industries engaged in complex processes & handling hazardous materials, such as food manufacturing, are particularly susceptible to these inefficiencies. The absence of real-time monitoring & predictive maintenance further amplifies these challenges, driving up operational costs & reducing capacity utilization. Incipientus has developed INCIFLOW, a revolutionary solution that transforms fluid analysis with its patented touch-free sensor technology. Supported by over 20 years of research, INCIFLOW delivers continuous, real-time viscosity & velocity profile data directly within production lines, setting a new benchmark in non-invasive fluid characterization. The system integrates ultrasound sensors & differential pressure ports into industrial-grade stainless steel pipes, allowing ultrasonic pulses to capture scattered energy from fluid particles. This cutting-edge technology produces a comprehensive multi-point rheogram, providing continuous, real-time measurements of viscosity & velocity profiles. The resulting data offers a detailed analysis of fluid behavior under actual operating conditions, easily accessible through a user-friendly digital platform for effective process control. Utilizing Ultrasonic Velocity Profiling (UVP) & combining it with Pressure Difference (PD) measurements, INCIFLOW enables full shear rate & flow behavior analysis. This approach surpasses traditional rheometers by generating a complete multi-point rheogram from a single flow profile & pressure measurement, delivering advanced insights into process dynamics.

Keywords: industry flow process technology,smart sensors,food process monitoring,energy efficient,green technologies