Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Prevalence, 1-year incidence and symptom severity of mental disorders in the elderly: Relationship to impairment, functioning (ICF) and service utilisation (MENTDIS_ICF65+)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Germany,Italy,United Kingdom,Spain,Switzerland,Israel,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-10-01
End date: 2013-03-31
Duration (months): 54.0
Total project cost (EUR): 3919217.0
EU funding (EUR): 2997684.0
Participants: 7
Project status: CLOSED

Reliable data on the prevalence and incidence of the spectrum of mental disorders in older people are currently lacking for the EU. Despite the availability of some national and a few cross-national cross-sectional studies with quite variable results, the size and burden of mental disorders in the elderly remains unclear. This has been attributed to a number of methodological factors (e.g. lack of appropriate diagnostic instruments). In addition patterns of incidence and of the natural course and prognosis of mental and physical disorders in people above 65 years are lacking nationally and cross-nationally in the EU, with only a few notable exceptions. Furthermore, there are no cross-national studies investigating the interaction of mental disorders and the utilisation of treatment under specific consideration of the severity and the impairment of activities and participation, in terms of ICF-categories, of older people in different European countries. Therefore, the objective of the proposed study is to (1) develop, respectively to adapt existing instruments and (2) to collect data on the prevalence, the incidence and on the natural course and prognosis of mental disorders, and to do this in sufficiently powered representative samples of older people living in the community across different European countries. This includes assessing health service needs, investigating to what extent existing services are used by older people and which specific barriers to utilisation may exist. Thereby, the implementation of the study will enable the further development and improvement of harmonised instruments for the assessment of impairments of activities and participation in older adults, to adapt already existing instruments, and to facilitate results that are comparable across cultures. Results will help to change health care in direct contact with people, and beyond this, they offer starting points for structural changes initiated on the level of health politics.

Keywords: prevalence,symptom severity,elderly,service utilization,impairment functioning,icf,physical illness,incidence,course of illness
Services and Health for Elderly in Long TERm care (SHELTER)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Italy,Czechia,Germany,Finland,France,Israel,United Kingdom,Netherlands
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 3025598.4
EU funding (EUR): 2350758.0
Participants: 8
Project status: CLOSED

One of the most relevant obstacle to assess and compare nursing home (NH) services and patients across countries relates to the fact that standardized and validated methodologies are not routinely in use in daily practice in Europe. The Minimum Data Set (MDS) is a comprehensive assessment instrument which contains a standardized set of essential clinical and functional status measures and allows evaluation of patients characteristics, measures of quality of care and patients outcomes. This instrument provides the informational basis for a system of outcome management and quality assurance for elders receiving long term care. The MDS is a powerful tool that can serve to assess outcomes, to measure quality of care and to compare provision of care, health care organization and systems across countries. We proposed to conduct a study aimed to validate the use of MDS as a methodology to assess provision of care in NH in Europe. Such methodology will allow to: a. measure patients outcomes and identify predictors of outcomes (changes in physical function, cognitive status, mood, hospitalization and survival) both at a patient level and at a service level; b. evaluate and monitor quality of care provided and identify incentives to improve quality and enhance prevention; c. compare structural and organisational characteristics of NH Services in European countries, along with the clinical and functional characteristics of their residents. To this aim we propose a large cross-national, prospective, observational study enrolling older people in NH in European countries. NH residents in the study will be assessed using the MDS. Information collected with this instrument will contribute to the creation of the first cross-national database on NH in Europe and will contribute to the validation of a methodology of assessment of NH residents that can be applied on large scale.

Keywords: long term care,nursing home,elderly,minimum data set,quality of care,prevention,comprehensive geriatric assessment
Global Linkage Over BroadbAnd Links (GLOBAL)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Austria,Spain,Uruguay,United Kingdom,Slovenia,Netherlands
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-05-01
End date: 2010-10-31
Duration (months): 30.0
Total project cost (EUR): 1251651.0
EU funding (EUR): 880000.0
Participants: 7
Project status: CLOSED

GLOBAL - Global Linkage Over BroadbAnd Links will provide a virtual conference center using advanced communication technologies and concepts to support the promotion of e-infrastructure topics around the world. The GLOBAL project can be condensed in 4 objectives: • Objective 1: Providing the “Virtual Conference Center” Collaborative e-Infrastructure • Objective 2: Realising of Global Networking Sessions • Objective 3: Disseminating the Results and Providing Sustainability • Objective 4: Providing Services for Third Parties The members of the consortium have a large experience in organising virtual events.

Keywords: virtual conference center,e-infrastructure events,global knowledge exchange
Mathematical modelling of beta-catenin and ras signalling in liver and its impact on proliferation, tissue organization and formation of hepatocellular carcinomas (CANCERSYS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Germany,France,Germany,France,Germany,Germany,Sweden,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-11-01
End date: 2011-10-31
Duration (months): 36.0
Total project cost (EUR): 3989366.4
EU funding (EUR): 2992024.0
Participants: 9
Project status: CLOSED

The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with effects at the organ level will address the impact of these signalling networks on proliferation, tissue organization and formation of hepatocellular carcinoma. In a close collaboration of scientists from theoretical fields and life sciences, our approach will combine dynamic modelling of signalling networks with spatial-temporal modelling of the liver microarchitecture. For this purpose dynamic models of the beta-catenin and ras core modules and their interactions will be integrated into a single-cell based three-dimensional model of the liver lobule. This model will be used to predict the impact of beta-catenin and ras activation on tissue organization starting with the early events, such as enhanced proliferation as well as micromotility of single cells, followed by formation of nodules and finally of dedifferentiated hepatocarcinomas. Predictions obtained by the model will be validated by inducible Apclox/lox and Ha-rasQ61R mouse strains, which have already been established by members of our consortium and allow induction of hepatocellular carcinoma. In addition the model predictions of the combined influence of active beta-catenin and ras signalling will be validated using a mouse strain that allows induction of both pathways in hepatocytes. In an iterative process, the model will be validated and adjusted to the in vivo situation. The model aims at the identification of systems properties of beta-catenin and ras signalling exploited during carcinogenesis and will foster the prediction of strategies for effective intervention, thereby facilitating the design of novel therapeutic strategies to combat hepatocellular carcinoma.

Keywords: multi-scale model,signal transduction networks,beta-catenin,hepatocellular cancer,primary hepatocytes,spatial-temporal modelling,liver microarchitecture
Developing and validating disease management evaluation methods for European health care systems (DISMEVAL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Austria,Denmark,Germany,France,Netherlands,Spain,France,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 3421035.8
EU funding (EUR): 2651891.0
Participants: 10
Project status: CLOSED

Chronic health conditions that impose a heavy burden on society and account for a large share of health care costs. Better prevention and management could potentially decrease costs and improve quality of care and health outcomes. An important means of accomplishing these goals is through the use of disease management (DM) interventions that educate patients about prevention and health management strategies, while also providing guidance, behavioral modification techniques, and social and emotional support. DM also seeks to assist providers by informing them about best practices and treatment opportunities. The underlying assumption is that DM leads to better quality of care, more health-conscious behavior, and improved disease prevention and control. In the short run, disease management would decrease costs by optimizing utilization of medical care. In the long run, DM lead to improved health status among patients with chronic conditions, thereby avoiding medical expenditures and improving workplace productivity. Many health care systems in Europe and elsewhere are beginning to embrace DM programmes. Although the concept of disease management offers great promise, these programs’ ability to reduce cost and improve care has not yet been empirically demonstrated; more and more policymakers are demanding objective assessments of a programme’s impact. Part of the problem is that there are no universally accepted evaluation methods to measure and report programme performance in a scientifically sound fashion that is also practicable for routine operations. This project seeks to bridge this gap. It will provide an overview of approaches to chronic care and DM methods across Europe and test and validate possible evaluation approaches. These include non-experimental and experimental evaluation designs and performance measures. Best practices will be identified and used to develop recommendations for policymakers, program operators and researchers.

Keywords: chronic diseases,evaluation,disease management,europe
European Genetic Disease Diagnostics (EURO-GENE-SCAN)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Sweden,United Kingdom,Germany,Poland,Sweden
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 3822299.0
EU funding (EUR): 2913807.0
Participants: 5
Project status: CLOSED

Molecular techniques have become more efficient, increasingly precise and much cheaper, resulting in an unprecedented discovery rate of inherited disease genes. In areas such as primary immunodeficiencies (PID), muscle disorders, growth deficiencies, hearing/vision impairments and metabolic diseases, very large numbers of different genes have been found to carry mutations in diseases with heterogeneous clinical presentation. For example, mutations in almost 150 genes have been found to cause PID. This means that even for well-defined subgroups of PID, mutations in different genes result in identical, or overlapping, phenotypes. Current mutation analysis is very complex, often with many different European laboratories being involved. Thus, individual laboratories carrying out mutation detection normally only cover a few per cent of all disease genes. Obtaining a correct diagnosis is both difficult and time-consuming. If multiple genes need to be analyzed, the cost rises proportionately. New sequencing approaches have been used for the analysis of whole genomes. We will adapt these technologies, based on massive, parallel sequencing, to specific disease fields. This will involve the development of an innovative multiplexing technology. The proposed prototype area is PID, where significant collaboration has already been underway in Europe over the last two decades. We estimate that, using high-throughput sequencing, the cost for analyzing all known 150 PID genes in a single run will be in the same range as the current cost for mutation detection in single disease genes. We will also develop chips to identify single nucleotide polymorphisms (SNPs) for the study of modifier genes. In addition, we will develop reverse-phase protein arrays for proteomics approaches in the diagnostics of PID patients during infancy. During the proposed project we will disseminate information and transfer the developed technologies to other disease areas.

Keywords: primary immunodeficiency diseases,high-throughput sequencing,genomics,proteomics,snp-chip,genetic disease diagnosis,rare disease
Imaging function and dysfunction of neuronal circuits in the visual cortex (EUROV1SION)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Germany,United Kingdom,Italy,United Kingdom,United Kingdom,Switzerland,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-12-01
End date: 2013-05-31
Duration (months): 54.0
Total project cost (EUR): 3479957.6
EU funding (EUR): 2598906.0
Participants: 8
Project status: CLOSED

The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - established chronic in vivo two photon imaging of Ca2+ responses in the visual cortex by making use of a novel genetically encoded Ca2+ sensor. Using this powerful new methodology we will study how experience changes firing properties of individual neurons of known identity and how this correlates with changes in inhibitory and excitatory synaptic structures. Using the same approach we will study the neuronal substrate of amblyopia and how it alters coding of visual information. Next we will study how binocular experience leads to recovery from amblyopia and how perceptual learning can improve this in animal models and human subjects. This knowledge will be directly translated into new treatments of amblyopia by one of the participating SMEs. Last we will study the molecular and cellular mechanisms that restrict plasticity in the adult visual system with the aim to achieve increased experience dependent plasticity in the adult brain. This knowledge can be used for the treatment of disorders of the CNS from which recovery is limited due to restricted plasticity. Apart from amblyopia, these include brain tumors, stroke, degenerative diseases and trauma. Together this program will provide comprehensive insight into the neuronal interactions underpinning function and dysfunction of the visual cortex and will contribute directly to improved treatment of amblyopia and development of plasticity based approaches for curing a large array of disorders of the CNS.

Keywords: visual cortex,amblyopia,ocular dominance,plasticity,strabismus,two photon imaging,calcium responses
Health in Times of Transition: Trends in Population Health and Health Policies in CIS Countries (HITT-2008)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Austria,United Kingdom,United Kingdom,Canada,Georgia,Belarus,Russian Federation,Ukraine,Moldova, Republic of,Kazakhstan
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-05-01
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 3350211.6
EU funding (EUR): 3000000.0
Participants: 13
Project status: CLOSED

Goal: To understand long-term trends of population health as a consequence of socio-economic transitions, with a focus on lifestyle-related issues. Overviews: A unique team with extensive expertise in health effects of transition will generate new knowledge on health determinants in 11 CIS countries: Russia, Belarus, Ukraine, Moldova, Kazakhstan, Uzbekistan, Kyrgyzstan, Armenia, Azerbaijan and Georgia. It employs a model of health determinants acting at individual and societal level, with distal and proximal influences on health. It focuses on alcohol, tobacco, diet, and health care, each linked to diseases specified in the call. Objectives: a) measure and explain prevalence and distribution of risk factors, health outcomes, and their social, cultural, and economic determinants; b) develop and implement validated community profiles to capture the opportunities and obstacles to leading a healthy lifestyle (in relation to diet, alcohol, smoking); c) assess health system performance, focussing on accessibility and quality of health services; d) quantify the cost of ill health through reduced labour supply and productivity; e) identify opportunities for and obstacles to policy change (alcohol and tobacco) in Russia: f) market analysis (alcohol & tobacco); g) regional analysis of alcohol -related mortality in Ukraine. Methods (corresponding to objectives): a) Large scale household surveys, multiple regressions; b&c) Rapid appraisal using structured observation, mapping, media analysis, interviews, focus groups d) econometric modelling (instrumental variables) e) stakeholder analyses f) econometrics g) multivariate analysis Finally, the project will bring concrete benefits by influencing policy in ways that will support health by: · disseminating findings within each country and to EU policymakers and international researchers; · identifying policy implications based upon informed research.

Keywords: trends in population and health,diet and nutrition,tobacco,alcohol,access to health care,living conditions,lifestyles and health,transition countries,cis countries
HEALTH PROfessional Mobility in THe European Union Study (HEALTH PROMETHEUS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Switzerland,Hungary,United Kingdom,Germany,Finland,Italy,Slovenia,Spain,Lithuania,Ireland
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-06-30
Duration (months): 42.0
Total project cost (EUR): 3098490.8
EU funding (EUR): 2510297.0
Participants: 11
Project status: CLOSED

Health professionals have always moved to, from and within Europe for work and other reasons. However, concerns about the scale of movement and its impacts on health systems are increasing. New disease patterns, new technology and increasingly global markets have multiplied pressures on health systems. Policy makers and managers need to respond but do not know enough about what is happening. EHMA and European Observatory on Health Systems and Policies are leading a multi-disciplinary team to address this information gap. 11 partners from 8 EU MS with 24 country correspondents / informants will provide missing data, an understanding of drivers for movement, and insights into mobility’s impact on health system access quality and sustainability. They will address 6 key objectives by answering the questions •How much professional mobility is there? •What is it about countries, health systems and people that encourage professionals to move? •What does mobility do to systems, professionals and patients? •What policy responses make a difference? •What are the future challenges? •What can decision makers do? This project progresses beyond the state of art by providing comprehensive maps of professional mobility and 19 country case studies. It will also capture and assess effective responses. Recommendations will be framed for policy makers and managers and reflect the likelihood of future change. They will emphasize accessible options and implementation of initiatives to recruit, integrate or retain staff. This project is timely, particularly given the complex risks and benefits of a fluid workforce, EU growth and the sometimes competing agendas of Lisbon and a Social Europe. The project will mix methods from quantitative data analysis to focus groups considering the international, national, regional and institutional levels; to best answer the questions above; and generate advice for stronger, more appropriate human resource policies.

Keywords: health professionals,health services,professional mobility,human resources policy,health policy,europe,health systems,international health policy,mutual recognition of diplomas,brain drain