Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Supramolecular attack particles to prevent cancer recurrence (SMAPCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Supramolecular attack particles (SMAPs) are proteinaceous particles ~120 nm in diameter released from cytotoxic T cell and natural killer cells. The particles have a core of cytotoxic proteins including perforin andgranzymes enveloped in a dense shell of glycoproteins including thrombospondin-1, which provides specificity for SMAP mediated killing. SMAPs released from T-cells are stable for at least 24 hours and can kill target cells autonomously. The human cell line NK92 secretes SMAPs based on inclusion of perforin and granzyme B. We have filed a patent on SMAP engineering and isolation and propose to work with experts in glioblastoma (GBM) and ovarian high-grade serous carcinoma (OC), and with interest from a biotech company with expertise in particle based therapies, to develop SMAPs as cancer therapies. GBM and OC are both diseases with high unmet need that are treated by surgical resection followed by chemo-radiation and patients succumb to local recurrence. GBM and OC don’t respond to immunotherapies. As SMAPs are autonomously cytotoxic and can readily be delivered to surgical sites to destroy residual disease after resection we see an opportunity to develop SMAPs as therapies to reduce recurrence. The next step after SYNECT completion will be to determine if SMAPs can be used to attack the tumour selectively without damage to normal tissues. We request funding to enrich SMAPs from NK92 cells supernatants and test these against GBM and OC cell lines in vitro. We will also label SMAPs with fluorescent dyes and test biodistribution and toxicity in mouse models of intravenous, intracranial and intra-peritoneal injection. This 1 year effort will enable mathematical modelling to design efficient preclinical studies in humanized mouse models in one or both of these indications that will be funded by future grants or private sector investment. These results will also enable refinement of intellectual property, value creation and commercialization plans.

Keywords: cancer immunotherapy,immunological synapse,cytotoxic t cells,extracellular vesicles,glioblastoma,ovarian cancer
Rain Forest GreenHouse Gases (RainForest-GHG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

RainForest-GHG aims to quantify ecosystem sinks and emissions of three major greenhouse gases (GHGs), i.e. carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), in a tropical rainforest, and examine the contributions of the soil and the woody tissues to the ecosystem-scale GHG fluxes. RainForest-GHG further aims to determine the main environmental drivers responsible for the temporal and spatial variations of these GHG fluxes.

Keywords: ecophysiology,ecosystem gas emission,frorest dynamics,global carbon cycle,greenhouse gases,soil,trees,tropical rainforest
Smart wavy patterned implants with instructive properties for tissue regeneration by controlling the degree of fibers buckling. (BUCKLING BRIDGES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration into electrospun scaffolds. Whereas this has a direct impact in CELL HYBRIDGE as part of the planned activities, we unexpectedly discovered that the same scaffolds display wavy patterns that have a direct influence on cell differentiation by enhancing their intrinsic capacity to produce growth factors. Driven by these observations, we have optimized the methodology and are able today to control the formation of such wavy patterns at a single fiber as well as multiple fiber scales by controlling the degree of buckling that the fibers are exposed to during processing. In doing so, we can reproduce the same waviness that is observed in several native tissues, among which tendons and ligaments. The aim of BUCKLING BRIDGES is to further investigate these instructive scaffolds as potentially smart implants for the regeneration of anterior cruciate ligaments. This will be done by further confirming our in vitro data and proof our concept by showing successful ligament regeneration in a preclinical animal model. While doing so, we will also explore the market potential of such products and develop a business plan for the creation of a spin-off company: TISSUE BRICKS.

Keywords: biofabrication,electrospinning,regenerative medicine,scaffolds,ligament,tendon
Ceramide Synthases in Diabetic Beta Cell Demise (CESYDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1492313.75
EU funding (EUR): 1492313.75
Participants: 1
Project status: SIGNED

Sphingolipids including ceramides are building blocks of cell membranes, but also act as regulated intracellular messenger molecules. Emerging data indicate that sphingolipids are dynamically regulated by nutrients, and in turn control systemic metabolism, for example, by modulating insulin secretion, proliferation and cell death of pancreatic beta cells. Dysfunction and death of beta cells are key events during the development of diabetes, from which more than 400 million patients suffer worldwide. While pharmacological inhibition of general ceramide biosynthesis is protective against diabetes in animal studies, side effects of total loss of ceramides prevent medical implementation. The de novo synthesis of ceramides is fully dependent on six ceramide synthase enzymes (CerS 1-6), which are expressed in a tissue specific manner, and generate ceramides with different chain lengths. Currently, the functional roles and regulatory modulators of each CerS are unknown in pancreatic beta cells. Importantly, the downstream mechanisms by which ceramides impair beta cell function and eventually cause diabetes are not defined. Here, I propose to combine genomics, proteomics and lipidomics to assess the function of ceramide synthases expressed in mouse and human beta cells. Furthermore, both the subcellular localisation and the post-translational modifications of CerS will be determined. The ceramide-interacting proteins mediating the deleterious effects of ceramides will be identified by lipid-protein crosslinking and functionally tested. Finally, in a translational approach, we will test the ability of recently generated novel specific CerS inhibitors with improved specificity to ameliorate beta cell stress, and improve insulin secretion in mouse and human beta cells. In sum, we will identify, characterize, validate and target ceramide synthases involved in beta cell biology and development of diabetes.

Keywords: diabetes,pancreatic beta cell,insulin secretion,apoptosis,sphingolipids,ceramides
Baltic Region Initiative for Long Lasting InnovAtive Nuclear Technologies (BRILLIANT)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Estonia,Sweden,Lithuania,Poland,Lithuania,Latvia,Latvia
Call: Regional initiative aiming at nuclear research and training capacity building (NFRP-2014-2015, 2014)
Start date: 2015-07-01
End date: 2018-06-30
Duration (months): 36.0
Total project cost (EUR): 1197345.0
EU funding (EUR): 1197345.0
Participants: 8
Project status: CLOSED

The region of the European Union around the Baltic sea especially the countries Estonia, Latvia and Lithuania are not adequately integrated to the European electricity grid. At the end of 2009 Ignalina NPP (Lithuania), which generated ~70-75 % of electricity in Lithuania and supplied electricity to Latvia and Estonia was permanently shutdown leaving the region without nuclear power generation. Lithuania, Estonia and Latvia are discussing building new NPP of ABWR type in Visaginas (Lithuania). Poland employed its own program for nuclear energy and is a potential partner for Visaginas NPP as well. New electricity grid interconnections Lithuania - Sweden and Lithuania - Poland are under construction and should start operation at the end of 2015 provide possibilities for synchronization of the electricity grid of the Baltic region with the continental Europe. Building new NPP affects the whole region not only in technological but in macroeconomic field as well. Different level of nuclear safety and radiation safety knowledge as well as R&D infrastructure exists in countries of the Baltic region. BRILLIANT is developed to find an optimal regional solution by creation of cooperation platform for modern electrical power solutions. This will be achieved by identifying the barriers for nuclear power development in Baltic region and preparing a ground for overcoming them. The project will support the exchange of knowledge, competences and infrastructure among the countries of Baltic region - Estonia, Latvia, Lithuania, Poland and Sweden. The company VAE SPB (Lithuania) is established for implementation of preparatory works of new Visaginas NPP. VAE SPB is an industrial partner in the project providing valuable insights and information. Cooperation among project partners would give better synergies with on-going and future Euratom projects in particular those offering access to research infrastructures in conjunction with education and training.

Keywords: regional cooperation,research,nuclear power,radioactive waste,electrical grid
Sociolinguistic typology and responsive features in syntactic history (STARFISH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1462872.5
EU funding (EUR): 1462872.5
Participants: 1
Project status: SIGNED

The aim of this project is to develop and test a new theory of variation and change in syntactic complexity, building on Trudgill’s (2011) theory of sociolinguistic typology and on the general architectural assumptions of Minimalist syntax. Trudgill (2011) makes the case that the distribution of simplicity and complexity across the world’s languages is related to the historical circumstances involved, with intense short-term contact involving extensive adult second language acquisition leading to simplification. This project will establish which syntactic features are "responsive" - that is, are susceptible to change under such circumstances. In the process, the project will bring together theories of second-language acquisition, syntax, computational modelling, and historical corpus linguistics to submit Trudgill's sociolinguistic-typological hypothesis to its most rigorous empirical test to date, in the domain of syntactic change. Crucial questions, such as the proportion of L2 acquirers and population structure necessary for simplification, will be teased out and addressed using computational modelling. We will look for responsive features in the domains of negation, Case, and subject expression, using the new generation of parsed historical corpora containing dated and localized texts at a high temporal and geographical resolution (e.g. the Corpus of Historical Low German currently in development), and put our theory and model to the test in these domains. The impact of the project will be to establish a new synthesis of historical sociolinguistics and syntactic theory that makes developments in each accountable to the other.
EnTimeMent - ENtrainment and synchronization at multiple TIME scales in the MENTal foundations of expressive gesture (EnTimeMent)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Australia,Italy,Sweden,Sweden,Greece,France,France,Netherlands,United Kingdom,United Kingdom,Canada
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 4206385.86
EU funding (EUR): 4188885.86
Participants: 13
Project status: SIGNED

EnTimeMent aims at a radical change in scientific research and enabling technologies for human movement qualitative analysis, entrainment and prediction, based on a novel neuro-cognitive approach of the multiple, mutually interactive time scales characterizing human behaviour. Our approach will afford the development of computational models for the automated detection, measurement, and prediction of movement qualities from behavioural signals, based on multi-layer parallel processes at non-linearly stratified temporal dimensions, and will radically transform technology for human movement analysis. EnTimeMent new innovative scientifically-grounded and time-adaptive technologies operate at multiple time scales in a multi-layered approach: motion capture and movement analysis systems will be endowed with a completely novel functionality, achieving a novel generation of time-aware multisensory motion perception and prediction systems. The proposed model and technologies will be iteratively tested and refined, by designing and performing controlled and ecological experiments, ranging from action prediction in a controlled laboratory setting, to prediction in dyadic and small group interaction. EnTimeMent scenarios include health (healing and support of everyday life of persons with chronic pain and disability), performing arts (e.g. dance), sports, and entertainment group activities, with and without living architectures. EnTimeMent will create and support community-building and exploitation with concrete initiatives, including a community of users and stakeholders, innovation hubs and SME incubators, as premises for the consolidation beyond the end of the project in a broader range of market areas.

Keywords: time adaptive technologies,motion capture,movement analysis,entrainment,neuroscience,computational models
Charting the process of getting forgotten within the humanities, 18th – 20th centuries: a historical network research analysis (FHNR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2019-09-30
Duration (months): 12.0
Total project cost (EUR): 88799.4
EU funding (EUR): 88799.4
Participants: 1
Project status: CLOSED

How did scholars get forgotten between the early 18th and the 20th century? To solve this question, the references to four humanities scholars (Dutch, English, French, and German) who worked on related fields, occupied similar posts, died in the first half of the 18th century and are little known today are to be tracked and compared by using historical network analysis (HNR) based on the tool NodeGoat. The sample of scholars is composed of Adrien Reland (1676-1718), Professor of Oriental Languages and Biblical Antiquities at Utrecht University; Johannes Braun (1628-1702), Professor of Theology at Groningen University; Thomas Gale (1636-1702), Professor of Greek at Cambridge University; and Eusebè Renaudot (1646-1720), Member of the Academie Française and the Academie des Inscriptions et Belles-Lettres. References to them from an academic background are to be tracking during their lifetime as well as posthumously and to be entered in a structured NodeGoat database for HNR analysis. These references include quotations and citations as well as being explicitly mentioned in letters and in print, where print encompasses both journals and books. They are to be collected by search within digitized corpora as well as in library holdings and archival materials. The HNR analysis will then reveal patterns of reference and point to clusters where specific in-depth archival researches have to be carried out.

Keywords: historical network research
Nonlinear-Distortion Free Communication over the Optical Fibre Channel (FRECOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Motivation The enormous growth in the Internet of Things and server farms for cloud services has increased the strain on the optical communication infrastructure. By 2025, our society will require data rates that are physically impossible to implement using current state-of-the-art optical communication technologies. This is because fibre-optic communication systems are rapidly approaching their fundamental capacity limits imposed by the Kerr nonlinearity of the fibre. Nonlinear distortion limits the ability to transport and detect the information stream. This is a very critical problem for increasing the data rates of any optical fibre communication system. Proposed research The only physical quantities not affected by the nonlinearity are eigenvalues, associated with the optical fibre propagation equation. Eigenvalues are thereby ideal candidates for information transport. The concept of eigenvalues is derived under the assumption that the fibre is lossless and that there is no noise in the system which is not strictly correct. Therefore, novel methodologies and concepts for the design of a noise mitigating receiver and a noise robust transmitter are needed to reap the full benefits of optical communication systems employing eigenvalues. This proposal will develop such strategies. This will be achieved by combining, for the first time, the fields of nonlinear optics, optical communication and nonlinear digital signal processing. The results from the project will be verified experimentally, and will form the basis for a new generation of commercial optical communication systems. Preliminary results Our proof-of-concept results demonstrate, for the first time, that noise can be handled by employing novel receiver concepts. An order of magnitude improvement compared to the state-of-the-art is demonstrated. Environment The research will be carried out in close cooperation with leading groups at Stanford University and Technical University of Munich.

Keywords: optical communication,nonlinear optics,signal processing
Plugplay gasification plant for onsite conversion of otherwise unusable waste into renewable energy (SYNERGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-02-28
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Typical gasification processes’ design, control and capital investment make it profitable only for medium-large scale with important throughput (plant > 1 GWh per year of electricity, with investment costs > 1M€). This falls well beyond the needs of the medium standard industrial consumption band, with annual electricity consumption between 500 and 2,000 MWh, i.e 3-4 orders of magnitude lower. Hysytech is positioned at this market gap. Synergy technology represents a novel turn-key product for the conversion of by-products from industry into fuel gas (syngas) through gasification. Synergy can be easily adapted as part of the production process of industrial manufacturing plants, with a treatment capacity of 100 kg per hour, generating 800 MWh per year of electricity and 600 MWh of useful heat. One of the biggest advantages of Synergy is making gasification affordable and profitable for small volume plants to be installed at manufacturing sites without the need of modifying the usual process or hiring new specialised operators. The selling price of Synergy gasification plant is estimated at €400 k including the installation of a fully ready-to-operate plant. This makes gasification an affordable and profitable investment for a medium industrial site, with a payback period of 2 to 5 years. This new technology has been developed after a preliminary assessment of some business opportunities on the field. The result is an existing prototype plant (processing 10kg/h) with the improved design of the complete plant, including the fluid bed reactor and gas clean-up system. Funded in 2003, Hysytech is today a pioneer in the field of process engineering and, in particular, in the design and construction of turn-key plants for fuel chemical processing, energy production and environmental treatment with its processes installed in more than 450 industrial sites. The Synergy project is a natural continuation of its experience and capability.

Keywords: gasification,industrial waste,cogeneration,syngas,waste to energy,renewable energy,onsite generation