Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic Integrated structural and proteomic Analysis of the LUBAC complex and its involvement in NF-κB and inflammation (DIAL-IN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2019-03-02
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

One of key challenges in current biology is to characterize the genotype to phenotype transition and explain how genomic variation results in specific phenotypes. According to the 'modular biology' paradigm, dynamically regulated multi-protein modules mediate this transition. My project aims at testing this paradigm by applying to a clinically highly relevant case study an integrated workflow of new technologies developed in the host laboratory. In particular, I will focus on a novel ubiquitin ligase complex, linear ubiquitin chain assembly complex (LUBAC), a critical but poorly understood player in several inflammation-related pathways, most notably the canonical NF-κB pathway. Given its key role in the pathogenesis of inflammation, understanding LUBAC will have fundamental biomedical implications. To investigate its structure, function and regulation, I will integrate data generated by mass spectrometry, which is the focus of the Aebersold laboratory, and cryo-electron microscopy (cryo-EM), which is the main expertise I acquired during my PhD. First, I will use quantitative affinity-purification coupled to mass spectrometry (AP-SWATH) to identify the dynamic interactome and the post-translation modifications (PTMs) of LUBAC. I will then define the structure of the complex by combining available atomic models of known LUBAC components, cryo-EM and cross-linking coupled to mass spectrometry (XL-MS). Finally, I will study clinical mutants and map the repercussions of genetic variation at the level of the complex organization, its interactome and of the global proteomic landscape. By these means, I will give a systemic and mechanistic account of the genotype to phenotype transition in clinically relevant scenarios. The output of the project, in line with the Work Programme, will be the production of new knowledge of fundamental biological and medical relevance and the development and validation of enabling technologies at the forefront of molecular biology research.

Keywords: lubac,nf kb pathway,ubiquitin signaling,mass spectrometry,method development,modular biology
Quantum superiority with coherent states (QUSCO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2024-06-30
Duration (months): 78.0
Total project cost (EUR): 1494738.0
EU funding (EUR): 1494738.0
Participants: 1
Project status: SIGNED

The unique features of quantum mechanics enable communication and computation tasks impossible to achieve by classical means. This opens a tremendous potential for enhancing the power, efficiency and security of everyday interactions in our information-based society. The quest of the demonstration in physical systems of quantum superiority has led to milestone implementations, most notably of the distribution of secret keys with unconditional security or of elementary computations such as the efficient sampling of bosonic distributions. In this project, we propose to develop and experimentally demonstrate a framework where quantum resources can be used to outperform their classical counterparts for a much larger range of problems than key distribution or boson sampling, with applications in algorithms, cryptography, communications, scheduling, routing, data mining, process monitoring and control or DNA sequencing. The theoretical basis of our framework is decomposed in three well defined elements-circuits, of increasing complexity, which can individually be used for specific quantum enhanced applications and together lead to the demonstration of the holy grail of quantum information science – quantum superiority for hard computation algorithms. The implementation of all the elements will be based on a photonic experimental platform exploiting a mapping of quantum information protocols involving multiple quantum bits of information to protocols based on coherent states of light in a superposition of optical modes. This is extremely appealing from a practical point of view and will be fully explored, in particular using silicon photonic technologies that allow for scalable devices involving fast switching operations, compact delay lines, and reconfigurable couplers, the main components of our circuits. Our project sets a highly ambitious target, providing on the way powerful and readily accessible applications of quantum technologies.

Keywords: quantum communications,quantum computing,silicon photonics,optical communications,communication complexity
Engineering of Nanostructures with Giant Magneto-Piezoelectric and Multicaloric Functionalities (ENGIMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ukraine,Russian Federation,Slovenia,France,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-12-01
End date: 2023-04-30
Duration (months): 65.0
Total project cost (EUR): 882000.0
EU funding (EUR): 837000.0
Participants: 5
Project status: SIGNED

Nowadays smart materials play a crucial role in the next-generation of intelligent devices and sensors, smart homes, autonomous devices, and robotics. Nanostructuring materials open up new horizons bringing in their multifunctionality and reduce the energy consumption. This reveals new scientific avenues and paves ways for breakthroughs in technology. Realization of structured materials with the strong coupling of electric and magnetic order and large multicaloric properties is a milestone for modern electronics and the gate for fascinating applications. In this context, we develop the partnership within the RISE consortium ENGIMA, involving the academic partners from two EU Member States, France and Slovenia Third Countries Universities in Morocco and Russia the non-academic SME from Associated Country, Ukraine. The network combines the complementary interdisciplinary and intersectoral expertise with established collaboration between partners and clear potential for skills transfer and exchange of knowledge, extended from fundamental to applied physics and from material chemistry to industrial nanotechnologies. Consortium defined a research objective of exploring the nanostructures in a form of tethered magnetic 1-D/piezoelectric nanostructures and magnetic/piezoelectric superlattices to obtain new ferroic materials with giant magnetoelectric and multicaloric functionalities that have potential applications as magnetoelectric sensors and, telecommunication devices. This task will be achieved by joining the efforts through the staff exchange, sharing knowledge, innovation and by multidisciplinary training of the team of collaborating young researchers able to conduct the research and exploit its application to this new area.

Keywords: nanostructures,magnetoelectric coupling,ferroic materials,superlattices,multicaloric materials,piezoelectricity
LEARNING TO SLEEP: INCREASING HEALTH THROUGH BETTER SLEEP (LTS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Learning2Sleep is an online solution for helping people affected by insomnia and poor sleep. Bad sleep affects many people in the developed world. The stress of daily life and work affects sleep patterns, which in turn impacts work performance and quality of life. Given that pharmacological solutions such as sleeping pills are not effective and harbor many side effects and sleep therapy is very expensive, there are few avenues for people to seek help. Learning2Sleep is an online treatment developed by sleep experts versed in Cognitive Behavioral Therapy. It helps people get better anytime and anywhere through a therapeutic program available on mobile devices and the web.

Keywords: sleep,better health,productivity,lifestyle
5G ExPerimentation Infrastructure hosting Cloud-nativE Netapps for public proTection and disaster RElief (5G-EPICENTRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Spain,Germany,Spain,Germany,Spain,Ireland,Italy,Italy,Italy,Cyprus,Greece,Greece,Switzerland,France,Portugal,Portugal
Call: 5G PPP – 5G innovations for verticals with third party services (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 7883726.25
EU funding (EUR): 5999168.25
Participants: 18
Project status: SIGNED

5G is considered to be the next decade mainstream broadband wireless technology and can leverage the efficiency and effectiveness of everyday high demanding operations such as public protection and disaster relief (PPDR). ITU considers LTE-Advanced systems and 5G as a mission critical PPDR technology able to address the needs of mission critical intelligence by supporting mission critical voice, data and video services as an IMT radio interface. 5G-EPICENTRE will deliver an open end-to-end experimentation 5G platform focusing on software solutions that serve the needs of PPDR. The envisioned platform will enable SMEs and developers to acquire knowledge with regard to the latest 5G applications and approaches for first responders and crisis management, as well as to build up and experiment with their solutions. The 5G-EPICENTRE platform will be based on an open Service oriented Architecture, following the current best DevOps practices (containerization of micro-services) and will be able to accommodate and provide open access to 5G networks’ resources, acting this way as a 5G open source repository for PPDR NetApps. For the assessment of the abovementioned platform, the realization of several use cases is being foreseen which will be realized as a PPDR vertical. The purpose of the use cases is to expand along the entire range of the 3 ITU-defined service types (i.e. eMBB, mMTC and URLLC) as well as to provide the floor for overseeing the platform’s secure interoperability capabilities beyond vendor-specific implementation. The engaged SMEs and organizations that will participate into the realization of the use cases constitute active players in the public security and disaster management, thus acting as key enablers for the assessment of 5G-EPICENTRE with regard to the real needs that should be addressed. Finally, through the use cases realization, KPIs relevant to 5G will be measured, especially those that are pertain to services’ creation time.

Keywords: experimental platforms,ppdr,netapps,multi access edge computing,containerization
HARNESSING THE POWER OF NATURE THROUGH PRODUCTIVE MICROBIAL CONSORTIA IN BIOTECHNOLOGY – MEASURE, MODEL, MASTER (PROMICON)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Germany,Sweden,Switzerland,Bulgaria,Netherlands,Portugal,United Kingdom
Call: Industrial microbiomes – learning from nature (H2020-FNR-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 5999712.5
EU funding (EUR): 5999712.5
Participants: 11
Project status: SIGNED

The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. Advances in quantitative analysis modelling and design of these systems are urgently needed to improve the predictability and enable exploitation of the amazing synthesis capacities of microbiomes. The PROMICON project will learn from nature how microbiomes function through development and application of quantitative physiology, imaging, cell sorting machine learning and systems biology. This will be used to steer existing microbiomes towards production and to generate new synthetic microbiomes inspired by nature through an iterative design-build-test-learn cycle. The new consortia will also contain strains developed through systems metabolic engineering and will be used for the production of energy carriers, drop-in chemical feedstocks and advanced biomaterials. PROMICON will advance characterization tools to understand which strains (modules) are needed for a successful microbiome. It will identify the primary producers (farmers), secondary converters (labourers) and essential strains for microbiome stability (balancers). This knowledge will be used to reduce complexity of natural microbiomes for optimized production of phycobilli protein based pigments, exo-polysaccharides (EPS) and poly-hydroxyalkanoates (PHA) in a top-down approach. Secondly, synthetic microbiomes with increasing complexity (bottom-up) will be assembled for the production of butanol, H2 and PHACOS, a functionalized antimicrobial polyester. PROMICON will develop new reactor concepts and downstream processing for microbiomes and conduct early-stage life cycle assessment (LCA) to prepare exploitation. This ground-breaking project will not only inspire completely new production pathways and a paradigm shift from monocultures to mixed cultures in biotechnology, but also has the potential beyond biotechnology to inspire novel treatment options in biomedicine.

Keywords: productive microbiomes,systems biology,single cell analysis,cell sorting,systems metabolic engineering,metabolism,synthetic consortia,capillary reactors,machine and deep learning
Building Data Rich Clinical Trials (CCE_DART)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Spain,Sweden,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Towards the new generation of clinical trials – trials methodology research (H2020-SC1-2020-Lump-Sum-RTD, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 6175323.93
EU funding (EUR): 5999411.25
Participants: 12
Project status: SIGNED

Successful drug approvals on Precision Oncology (PO) using basket studies have uncovered new challenges. Research in small patient populations suffers from sustainability/ logistical issues. Platform trials are flexible solutions to test different drugs in different populations but encompass management issues that compromise flow and translational research. This is detrimental to patients/ researchers thus new technological/ methodological concepts must be urgently implemented. To overcome these limitations, Cancer Core Europe (CCE) has developed the Basket of Basket (BoB) study to provide personalized treatment to a larger number of patients by incorporating a multi-tiered molecular profiling platform, flexible modules targeting different molecular alterations and a data/ sample collection plan to enable translational research. The CCE-DART model, here proposed, is conceived to address other limitations of PO and platform trials identified by our multi-disciplinary team. With a new design, we aim to improve efficiencies and transform platform trials in data-rich translational research programs, by: (1) developing digital systems (information-technology solutions) facilitating data management and clinical-decision-making; (2) integrating accurate, dynamic imaging and molecular markers of tumor progression/ drug response; (3) using more efficient, adaptive clinical trial methodology; (4) increasing patient engagement. To achieve this, we will use harmonized data-sharing/ technological/ legal/ clinical infrastructure developed in CCE and the BoB trial that will be leveraged as a use case for testing the new model. The new concept will impact the design of new clinical trials consolidating a self-sustainable, data-rich, multi-endpoint global platform for clinical/ translational research, encompassed by a pharmacoeconomics assessment that will proof the sustainability of the model for its implementation in the Health System and as a return of the investment to society.

Keywords: personalised cancer medicine,new clinical trial designs,biomarker discovery,digital tools,real world data,patient empowerment,basket of baskets,cancer core europe
ChiplEss MultisEnsor Rfid for GrEen NeTworks (EMERGENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Spain,France,France
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 913500.0
EU funding (EUR): 913500.0
Participants: 6
Project status: CLOSED

EMERGENT takes up the broader scope of Marie Skłodowska-Curie Research and Innovation Staff Ex-change Scheme of promoting knowledge-sharing-based cooperation and moves its steps forward to actual-ly support and facilitate the movement of skilled people between academia and industry committed to work on a research topic dealing with green chipless RFID tags and sensors. EMERGENT will move towards strengthening of existing inter-sectoral networks between the three EU re-search institutes and the three EU SMEs involved by implementing a total of 68 knowledge transfer se-condments in order to facilitate the joint research and innovation work aiming to realize a new class of chipless RFID tags and sensors moving from conventional sensors towards next generation pervasive interconnected systems by employing environmental-friendly substrates such as paper and low-cost printing process. EMERGENT will design hand in hand with both the chipless tag and sensor a dedicated reader for extracting the desired information. To this aim, novel signal processing algorithms will be developed and tested. EMERGENT will focus on system parameters of prominent relevance reliability, calibration) to assess the true performance of the tag, and to make comparisons among different implementations. The critical issues regarding the sensitivity and resolution of the reader will be carefully addressed and solved. EMERGENT will deliver wireless passive chipless smart tags and sensors able to sense the changing environment by collecting information about quantities of interest which may include temperature, humidity, stress, gases. EMERGENT will enhance the performance and robustness of chipless RFID sys-tems and will bring RFID sensing outside research laboratories towards self-consistent products.

Keywords: chipless rfid tags,chipless rfid sensors,low cost printing process,low cost uwb radars,chemical interactive materials,environmental friendly sensing device,hazardous environments
C° symplectic geometry (CSG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 1345282.0
EU funding (EUR): 94000.0
Participants: 2
Project status: SIGNED

The objective of this proposal is to study "continuous" (or C^0) objects, as well as C^0 properties of smooth objects, in the field of symplectic geometry and topology. C^0 symplectic geometry has seen spectacular progress in recent years, drawing attention of mathematicians from various background. The proposed study aims to discover new fascinating C^0 phenomena in symplectic geometry. One circle of questions concerns symplectic and Hamiltonian homeomorphisms. Recent studies indicate that these objects possess both rigidity and flexibility, appearing in surprising and counter-intuitive ways. Our understanding of symplectic and Hamiltonian homeomorphisms is far from being satisfactory, and here we intend to study questions related to action of symplectic homeomorphisms on submanifolds. Some other questions are about Hamiltonian homeomorphisms in relation to the celebrated Arnold conjecture. The PI suggests to study spectral invariants of continuous Hamiltonian flows, which allow to formulate the C^0 Arnold conjecture in higher dimensions. Another central problem that the PI will work on is the C^0 flux conjecture. A second circle of questions is about the Poisson bracket operator, and its functional-theoretic properties. The first question concerns the lower bound for the Poisson bracket invariant of a cover, conjectured by L. Polterovich who indicated relations between this problem and quantum mechanics. Another direction aims to study the C^0 rigidity versus flexibility of the L_p norm of the Poisson bracket. Despite a recent progress in dimension two showing rigidity, very little is known in higher dimensions. The PI proposes to use combination of tools from topology and from hard analysis in order to address this question, whose solution will be a big step towards understanding functional-theoretic properties of the Poisson bracket operator.

Keywords: c 0 symplectic geometry,continuous hamiltonian flow,symplectic and hamiltonian homeomorphisms,c 0 flux conjecture,c 0 rigidity,robustness of the poisson bracket,poisson bracket invariants