Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Defining heterocellular signalling within the intratumoral stem cell niche of colorectal cancer (IntratumoralNiche)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Purpose: Cells in a tumor are highly heterogeneous. The role and consequence of having multiple cell types within a cancer is mostly centered towards the function of cancer stem cells (CSCs) since they are the driving forces of tumor growth. However, the exact signaling cues that support CSC function remain to be understood. For instance, what are the roles of immediate descendant tumor cells in relation to CSC support? Do colorectal tumors make their own niche? Preliminary data: To study communication between different cell types (heterocellular signaling) in human colorectal cancers (CRCs), my lab developed movieSTAR technology to mark CSCs in patient-derived CRC organoids (PDOs) for high-resolution live imaging of their dynamics and behavior. Although niche factor dependency decreases along the adenoma-carcinoma transition, we identified a strong interdependency between CSCs and other tumor cells in colorectal PDOs of malignant nature. Hypothesis: We hypothesize a continuous existence of an intratumoral stem cell niche that remains essential for tumor growth and metastasis formation. Which types of heterocellular signaling support CSC function, especially at malignant stages, is unknown. Approach: This project aims to define heterocellular signaling between CSCs and intratumoral niche cells. Therefore, I) we will combine our expertise in human organoid technology for in-depth characterization of the nature of heterocellular communication within the intratumoral niche, II) high-resolution live imaging of PDOs to interrogate heterogeneity of signaling activities at cellular resolution and in real-time, as well as III) in vivo mouse models for validation and further studies of essential intratumoral signaling pathways. Innovation: Our integrative use of novel approaches will provide comprehensive insight into intratumoral niche function during tumorigenesis, establishing novel technologies for future cancer research and new concepts to improve cancer therapy.
Energy-saving and reducing carbon emissions by applying advanced ultrasonic technology to industrial maintenance services for compressed air systems (E-saving Ultrasonics)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SONOTEC aims to develop innovative ultrasonic measurement devices and sensors primarily applied to highly improved methods for leak detection and estimation of the degree of energy-loss in compressed air systems to facilitate the reduction of energy-waste and carbon emissions among industries. Compressed air is accounted for about 10 % of industrial consumption of electricity in the world. Estimates indicate direct accountability to an annual electricity consumption of over 120 TWh (>90 million tons of CO2) in the EU and over 760 TWh (>570 million tons of CO2) worldwide. Alarming ~30 % of the energy used in compressed air systems is wasted due to leakages. Prevention and repair of leaks are emphasized as the means with highest savings potential (over 42 %). Estimated reductions of energy-waste of over 15 TWh and carbon emissions of over 11 million tons of CO2 per year could be achieved by leak detection and repair only in the EU. Technologies based on non-harmful ultrasound are commonly used in almost every sector of industrial maintenance. Though existing technology and methods be applied to leak detecting and evaluation in compressed air systems are greatly simplified and not adequate to provide realistic estimations of the physical nature and size of leakages. SONOTEC’s realisation of an innovative product will be in form of a novel mobile/handheld device with modular equipment combining modern components for air ultrasonic sensors, measurement principles, testing procedures, embedded IT and a flexible interface for user-oriented maintenance management. Basic research has been completed and prototypes are successfully developed (TRL 6/7). The new sensor materials based on piezoelectric composites provide higher sensitivity and broader frequency range meeting the requirements for advanced maintenance services of modern industries to reduce energy-waste as well as carbon emissions and accordingly production costs.

Keywords: energy waste,carbon footprint,ultrasound,measurement and testing equipment,technological excellence,market leadership
Electron Quantum optics in quantum Hall edge channels (EQuO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2022-03-31
Duration (months): 78.0
Total project cost (EUR): 1997878.0
EU funding (EUR): 1997878.0
Participants: 2
Project status: CLOSED

Quantum effects have been studied on photon propagation in the context of quantum optics since the second half of the last century. In particular, using single photon emitters, fundamental tests of quantum mechanics were explored by manipulating single to few photons in Hanbury-Brown and Twiss and Hong Ou Mandel experiments. In nanophysics, there is a growing interest to translate these concepts of quantum optics to electrons propagating in nanostructures. Single electron emitters have been realized such that single elementary electronic excitations can now be manipulated in the analog of pioneer quantum optics experiments. Electron quantum optics goes beyond the mere reproduction of optical setups using electron beams, as electrons, being interacting fermions, differ strongly from photons. Contrary to optics, understanding the propagation of an elementary excitation requires replacing the single body description by a many body one. The purpose of this proposal is to specifically explore the emergence of many body physics and its effects on electronic propagation using the setups and concepts of electron quantum optics. The motivations are numerous: firstly single particle emission initializes a simple and well controlled state. I will take this unique opportunity to test birth, life and death scenarii of Landau quasiparticles and observe the emergence of many-body physics. Secondly, I will address the generation of entangled few electrons quantum coherent states and study how they are affected by interactions. Finally, I will attempt to apply electron quantum optics concepts to a regime where the ground state itself is a strongly correlated state of matter. In such a situation, elementary excitations are no longer electrons but carry a fractional charge and obey fractional statistics. No manipulation of single quasiparticles has been reported yet and the determination of some quasiparticle characteristics, such as the fractional statistics remains elusive.

Keywords: single electrons,quantum optics with electrons,noise,hong ou mandel,coulomb interaction,decoherence,fractional quantum hall effect
Innovative services and platform for sustainable transport based on ecodriving techniques (EUROCATED)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Eurocated project main objective consists of taking advantage of the opportunity presented in the market by the necessity of saving costs and reduce emissions in terms of fuel combustion in the operation of all kind of road transport professional fleets. Based on the principle of efficient driving, the solutions, products and services, proposed by this project, will fit a market all around Europe of more than 200 million € per year. Only Spanish market is ranged over 10 million € per year. Thousands of vehicles from public and private fleets will save billions € and tones of emissions, and fleet operators interest is growing as they become aware of the benefits of efficient driving technology supported systems over traditional training courses. Only a medium size city urban bus operator could save 375 thousand € per year and reduce emissions in 750 Tn per year. ADN Mobile Solutions distinguishes by its excellence in R&D activities that have permitted the firm to currently count with the most specialized, competitive and market oriented tech-powered efficient driving solution. After 4 years of developments, and with the support of public and private investors, the product has already achieved a TRL of 7, with operation on course of real trials and pilots in a number of early-adopters of the product: It is worth mentioning bus urban fleets operating in Valencia (Spain) and Oslo (Norway) cities as well as the already shown interest of Istanbul (Turkey) city . The feasibility study aims to prepare completed full operation plan that will fill the gap between the current product and the version to be widely disseminated and introduced at European level. ADN expectations consist of reaching an annual turnover of 10 million € by the end of 2019 with a phase II funding requirement estimated 1 million €.

Keywords: efficient driving eco driving safe driving fuel reduction fuel savings emissions reduction pollution monitoring
Characterisation of a Novel Pathway for Lignin Fragment Degradation in Rhodococcus jostii (PELIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-06
End date: 2018-10-05
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Lignin, composed of phenylpropanoic units, represents an attractive raw material for renewable aromatic chemicals. Lignin valorisation instead of petrochemical industry for chemicals production is a hot research area in green chemistry. Microorganisms have been proven to evolve metabolic pathways that enable the break-down of lignin; however, this lignin-to-chemicals bioconversion by both fungi and bacteria lacks essential attributes to commercial implementation. In the forefront, “omics” research has pointed out potential target genes and enzymes for manipulation, leading to more applied lignin bioconversion studies. Bacterial lignin metabolism is attracting more attention due to its relatively simple protein expression and genetic modification compared to fungi, which provides a potential application of a targeted pathway engineering strategy for diversified lignin-derived byproducts accumulation and yield enhancement. Hence, the discovery of unknown lignin metabolic pathways and gene products in bacteria is of importance. In this context, the current proposed research will explore and manipulate a novel lignin metabolic pathway - transketolase lignin degradation pathway - in Rhodococcus for lignin-based renewable chemicals production by using a synthetic biology approach. The goal will be achieved by pursuing the following two objectives: 1) elucidation and characterization of the novel enzyme encoded with tklX and evaluation of its activity reacted with lignin model compounds as transketolase; 2) targeted gene deletion for pathway engineering in genetically tractable hosts to manipulate lignin breakdown. The results of this study will therefore establish a promising foundation for production of lignin-derived chemicals from renewable feedstocks via catabolic pathways. Meanwhile, the Action will clearly provide the Applicant with unique opportunities to reach a position of professional maturity.

Keywords: green chemistry,lignin to chemicals bioconversion,bacteria,pathway engineering,enzyme,gene deletion
Cetacean Inner Ear (Cetacean Inner Ear)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-09-21
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The morphological study of cetacean cochlea as well as the possible alterations associated to sound exposure, represent a key conservation issue to assess the effects of acoustic pollution on marine ecosystems. Noise pollution could affect cetaceans by causing lesions in their inner ear, which can be severe enough to be lethal. In cases of severe permanent hearing loss, supporting cells of the organ of Corti replace apoptotic hair cells that are responsible for transducing the signal and enhancing auditory sensitivity and frequency selectivity. The objectives of this study consist in conducting a comparative ultrastructure morphological analysis of the cochlea from stranded cetaceans to 1) to assess their species specific hearing sensitivities by creating cochlear frequency maps and 2) to investigate possible lesions as a consequence of sound overexposure. Once the cochlear frequency map for a species is resolved, it will be possible to estimate the acoustic characteristics of a source that may have caused these lesions. In addition, this study will 3) investigate the process of hair cell apoptosis and the subsequent ‘scar’ formation to be able to distinguish newly formed lesions from old ones. Toothed whales have remarkable hearing protective mechanisms to insulate them from noise. Our research will also focus on 4) examining the potential elements that might play a role in this protective mechanism. To achieve these four objectives, the applicant will fine tune the protocol of ear analysis using electron microscopy and applying immunohistochemistry techniques. The expertise of the Hearing team of the Institute for Neurosciences of Montpellier (Inserm Unit 1051, France), and its microscopy and imaging facilities will be invaluable for the accomplishment of our study. This research will bring tools to the decision makers to better regulate marine activities and will contribute with essential knowledge for assessing the effects of noise pollution cetacean hearing.

Keywords: noise pollution,hearing loss,cetaceans,whales,inner ear,cochlea,hair cells,electron microscopy,immunofluorescence
A Diagnostic Testing Package for Childhood Synaesthesia (SYN-TOOLKIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom,United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2022-07-31
Duration (months): 31.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

People with the genetic trait of synaesthesia experience phantom colours, sounds, tastes, and other unusual sensations. These are triggered by everyday activities like reading or listening to music. Importantly, synaesthesia is comorbid with health conditions including anxiety disorder and autism, and has a known impact on education. Although there are widely available tests for diagnosing synaesthesia in adults, there are none for children - despite its relatively wide impact (307 million synaesthetes worldwide). My ERC Consolidator grant MULTISENSE has generated such a test, to share with fellow researchers. However, during the course of MULTISENSE we have been approached by multiple professionals beyond the research sector (e.g. clinicians), each in need of a diagnostic for the child synaesthetes they are increasingly encountering. These professionals require a test package comprising Diagnostic tool, Testing manual, Automatic Scoring, etc. which could be easily implemented by non-scientists. Not only is this testing package non-existent in any country worldwide, but it is requested from us on a regular basis. Hence, SYN-TOOLKIT will provide an app-based package to diagnose and support two of the most prevalent forms of childhood synaesthesia. We will trial our package on target audiences including partners in Local Education Authorities (with government oversight of schools) and the National Health Service. We will take our test-package to proof of concept by establishing technical feasibility, usability, and commercialisation. We have explored our market with an award that engaged the Sussex Innovation Centre, experts in market exploration. In summary, there is a pressing need to produce a commercialised test kit for childhood synaesthesia, for use by clinicians, education professionals and parents. This would address the striking lack of provision for children with synaesthesia, bringing benefits to synaesthetes, parents, educators, and clinical practice.

Keywords: synaesthesia,synesthesia,diagnostic,test package,children
A Disruptive Router Platform for the Internet of Things – TrustNode (TrustNode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The TrustNode project aims at prototyping, validation and demonstration of a disruptive routing platform in real world conditions. It will enable the design of novel routing paradigms asking for local intelligence to evaluate packet streams to serve upcoming B2B applications for the Internet of Things. Routing functionality is expected to migrate from core towards network edge in the next years. Outcome of the project will be (1) assessment of market share and manufacturing costs (2) business plan and (3) figures achieved by a prototype against SoA.

Keywords: router,routing,packet inspection
Ecocentric management for sustainable fisheries and healthy marine ecosystems (EcoScope)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Germany,Spain,Italy,Malta,Cyprus,Greece,Bulgaria,Greece,Norway,Belgium,Belgium,Greece,Greece,France,France,Philippines,Netherlands,Canada,United Kingdom,Portugal,Bangladesh
Call: Fisheries in the full ecosystem context (H2020-BG-2020-2, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 7919413.75
EU funding (EUR): 7919413.75
Participants: 27
Project status: SIGNED

The EcoScope project will develop an interoperable platform and a robust decision-making toolbox, available through a single public portal, to promote an efficient, ecosystem-based fisheries management. It will be guided by policy makers and scientific advisory bodies, and address ecosystem degradation and the anthropogenic impact that are causing fisheries to be unsustainably exploited across European Seas. The EcoScope Platform will organise and homogenise climatic, oceanographic, biogeochemical, biological and fisheries datasets for European Seas to a common standard type and format that will be available through interactive mapping layers. The EcoScope Toolbox, a scoring system based on assessments of all ecosystem components, ecosystem and economic models, will operate as a decision-support tool for examining fisheries management and marine policy scenarios and spatial planning simulations. Groups of end-users and stakeholders will be involved in the design, development and operation of both the platform and the toolbox. Novel assessment methods for data-poor fisheries, including non-commercial species, as well as for biodiversity and the conservation status of protected megafauna, will be used to assess the status of all ecosystem components across European Seas and test new technologies for evaluating the environmental, anthropogenic and climatic impact on ecosystems and fisheries. A series of sophisticated capacity building tools (online courses, webinars and games) will be available to stakeholders through the EcoScope Academy. The EcoScope project will provide an effective toolbox to decision makers and end-users that will be adaptive to their capacity, needs and data availability. The toolbox will incorporate methods for dealing with uncertainty; thus, it will promote efficient, holistic, sustainable, ecosystem-based fisheries management that will aid towards restoring fisheries sustainability and ensuring balance between food security and healthy seas.