Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantum Information Learning (QuaIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

This project aims at developing efficient, scalable and near-term-implementable decoders for long-distance communication on free-space or optical-fiber quantum channels. It is a timely proposal for the establishment of high-data-rate space communication and secure fiber communication. Its importance is recognized in the strategic quantum communication pillar of the EU Flagship on Quantum Technologies. In this setting, the main obstacle towards implementations is a joint quantum measurement, impossible with current technology. This project will investigate how to build a complex decoder by combining simple optical gates and photodetectors, augmented by a classical neural network that controls the quantum parameters and post-processes the measurement data. Moreover, it investigates the power of machine learning for quantum technologies, a very recent interdisciplinary field that still lacks killer applications. The applicant has a PhD and several excellent publications on the subject, while the host group comprises world-leading experts in quantum information theory and pioneers in the application of statistical-inference methods to it. Hence he is in the best position to carry out the project and become an established researcher, who will be acknowledged for his inter-disciplinary expertise and his contribution to an outstanding technological problem. The scientific part of the project is complemented with a well-balanced training program: advanced training-through-research, participation to a machine-learning school, transferable-skills for career development. The researcher will engage in teaching to undergraduate students, the organization of seminars and of a machine-learning reading club. Potential exploitation of the results will take place at a quantum industry day and hackathon. Moreover, outreach events will include an original proposal for the realization of a tape-art exhibition explaining quantum-mechanics by representing quantum-technological protocols.

Keywords: quantum communication,quantum gaussian channels,continuous variable quantum information,quantum shannon theory,quantum state discrimination,deep space communication,quantum machine learning
Immediate Oil Spill containment to mitigate impact on the marine ecosystem (OILBLOCK)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Israel,Netherlands,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2018-09-01
End date: 2021-12-31
Duration (months): 40.0
Total project cost (EUR): 3284188.75
EU funding (EUR): 2298932.14
Participants: 3
Project status: CLOSED

In Europe alone, about 20,000 oil spills were detected over a period of 6 years. Oil spills turn into major disasters because no immediate containment equipment is housed on-board large ships or oil rigs, so nothing can prevent oil from spreading during the first hours of a spill. OILBLOCK project goal is to bring to market Spill Python, the first in the world oil spill containment system on a proved Unmanned Marine System. OILBLOCK focuses on demonstrating the system in real world scenarios and enabling quick product commercialization. For this scope key value chain players are part of the consortium: HARBO Technologies, the developer of this disruptive technology; HEBO Maritiem, one of the largest Oil Spill Responders in Europe and ASV a leading producer of autonomous surface vehicles. OILBLOCK integrates HARBO’s core technology into a dedicated remote-controlled vessel that will be installed on-board tankers, oil rigs and large ships. This solution – Spill Python - will start operating immediately after spill detection and in less than 10 minutes, deploying up to 500 meters of a revolutionary containment boom. Spill Python will multiply oil recovery rates and significantly decrease the environmental impact and costs of spills. OILBLOCK is based on patented technology that has already been proven at the world's best testing facility. Many potential collaborators, such as emergency response organizations, coast guards, shipping lines, oil rig operators and coastal infrastructure facilities have already expressed interest in OILBLOCK solution. The project will help demonstrate first units for early adopters and put the consortium partners on a path to reach a sales rate of 270 units/ year by 2024 with an expected turnover of €94M. This growth will be reflected in the recruitment of up to 86 new employees in next five years. By 2028 sales are expected to reach 2,500 units/year due to regulators considering our technology as a benchmark for oil spill primary response.

Keywords: oil spill response,osro s,primary containment,boom,environment,oil spill
The role of vision on perceptual space representation (MYSpace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

To interact with the world that surrounds us, we rely on integrated spatial representations which we build during infancy. Visual experience is crucial for integrating sensory signals in a coherent configuration, taking into account the changes of body position in space. When vision is absent, as in the case of blind infants, how the space representation develops is still unclear. The aim of MYSpace is to identify the specific developmental periods when visual experience is crucial in establishing multisensory associations between vision and other modalities. Blind infants, blind children and blind adolescents will take part in longitudinal and cross-sectional studies spanning the developmental windows when spatial skills are acquired in sighted children. Advanced methods in psychophysics and neuroscience (high-density EEG and MRI), modeling and high-resolution motion tracking analysis will be used to investigate the following: - the role of vision on the development of independent (Objective 1) and multisensory (Objective 2) audio and tactile spatial representations at the behavioral and cortical levels; - the involvement of the visual cortex on this spatial processing when vision is absent (Objective 3); - the benefit of multisensory trainings to recover spatial impairments (Objective 4). By elucidating these aspects, the project will bridge a fundamental gap in the knowledge of spatial representations and determine how their development is shaped by visual experiences. As an outcome, MYSpace will provide a new quantitative methodology to restore the coherent spatial representations of blind infants through multisensory trainings.

Keywords: perception,action,visual disability,multi sensory integration,spatial perception,audio,tactile,rehabilitation,development,blind,plasticity
SOFT MATTER PLATFORM FOR OPTICAL DEVICES VIA ENGINEERING OF NON-LINEAR TOPOLOGICAL STATES OF LIGHT (TopoLight)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Poland,Switzerland,France,France,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-02-28
Duration (months): 42.0
Total project cost (EUR): 3099353.75
EU funding (EUR): 3099353.75
Participants: 6
Project status: SIGNED

Liquid crystals (LC) are advanced materials known for their anisotropic optical properties allowing to control the polarisation of light and are used in various optical devices. Now the time has come to push the LC applications further by implementing them into novel polariton devices to control topological properties of light. TopoLight deals for the first time with non-linear effects in room temperature Bose-Einstein condensate (BEC) and topological states of light uncovering astonishing possibilities of external electrical control over spin-orbit interaction due to artificially engineered fields acting on photons. With a two main technological approaches: originating from solid-state physics and developing molecular control of LC devices, we aim to demonstrate novel systems of tunable topological emitters based on room temperature BEC substantial in topological photonics and information encoding. We will design, fabricate and investigate photonic structures to start an innovative integrated hybrid organic/liquid-crystal system for room temperature BEC research and applications. Our disruptive innovation is based on the idea of external electrical control over spin-orbit coupling due to artificially engineered fields acting on photons, which has never been realised in photonics. We will create topologically protected states of light: unidirectional flow robust against backscattering and vortex states carrying quantised angular momentum. We will utilise the strong non-linearities observed in organic microcavities and SOC in liquid-crystal cavities to the demonstrate single photon polarisation switches capable for ternary logic. Our OLC microcavities (MCs) platform will combine a strong emissivity with the ease of fabrication, low costs, and scalability and room temperature operation.

Keywords: organic liquid crystal microcavities,strong light matter coupling,bose einsten condensates of exciton polaritons,single photon devices
Neural arithmetic of motion vision (MOVIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Signal processing by neurons involves arithmetic operations, many of which are nonlinear. These nonlinearities are thought to account for much of the brain’s computational power, yet, little is known about the molecular mechanics that underlie even simple operations like multiplication and division in individual neurons. I will address this problem in the visual system of Drosophila, where the detection of motion represents a canonical example of nonlinear information processing: To perceive visual motion, the signals of adjacent photoreceptors are differentially delayed to coincide at the dendrites of the bushy T-cells, T4 and T5, where multiplication and/or division of these inputs are thought to give rise to direction selectivity. The proposed work will address the following questions: Are the dendritic transformations multiplicative, divisive, or both? Which synaptic inputs constitute the numerator and which the denominator? What receptors and ion channels account for the dendritic nonlinearities and how do they influence the visual perception of motion? The fruit fly enables me to bridge molecular biophysics and optomotor behaviour by granting genetic, electrical, optical, and molecular access to virtually all relevant neurons in a circuit of well-documented synaptic connectivity and transcriptional activity. I will use whole-cell patch clamp recordings in vivo, patch-seq, optogenetics, optomotor behaviour, RNA interference, and computational modelling to identify the biophysical basis of multiplicative and divisive operations in the dendrites of bushy T-cells. The answers will likely hold information that extends beyond the fly’s sense of sight and might uncover previously unknown ways of signal processing by single neurons at the molecular scale.

Keywords: drosophila melanogaster,vision,direction selectivity,synaptic interactions,membrane biophysics
SLIGHT GRANULATION process reducing Water consumption in ceramic tiles industry (SLIGHT GRANULATION)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of SLIGHT GRANULATION project is to validate on the market an innovative production process, reducing both the use of water in ceramic industrial processes and the energy consumption. The new process will address a specific phase of production chain (i.e. granulation), reducing by 40% the use of water and completely cutting off the energy consumption in this phase. Before taking the final go to market decision, it will be necessary to carry out a wide and extensive market and feasibility study aiming at setting up the main economic and technical drivers leading the subsequent market deployment phase. While initial test have been already carried out through a pilot plant in small scale, the objective of the overall innovation program will be to set up a wider piloting phase, involving industrial actors that may support Manfredini and Schianchi in fine tuning operational parameters of Slight Granulation process. The objectives of the feasibility study will aim at obtaining direct feedback from potential users, before starting the full industrialization of the process. The low level objectives will be: - to lead at least 15 interviews with potential customers - to define a panel of at least 4 users to be involved in innovation phase - to clearly define functioning parameters of Slight Granulation process - to carry out a (preliminary) P&L for Slight Granulation plant business line; - to monitor IPR issues - to define technical road map for innovation phase The results of the validation study will be enclosed in a Business and innovation plan, that will be submitted as main deliverable at the end of the project

Keywords: ceramic tiles industry,water saving,energy saving
Physiological roles of the Ribotoxic Stress Response (PHYRIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1997678.0
EU funding (EUR): 1997678.0
Participants: 1
Project status: SIGNED

The ribotoxic stress response (RSR) surveys the structural and functional integrity of ribosomes and is triggered by diverse groups of ribotoxins (e.g. ricin), UV irradiation and some chemotherapeutics. When presented with impaired ribosomes, the proximal MAPKKK ZAK activates MAP kinases p38 and JNK to initiate a powerful inflammatory response. This signalling contributes to the detrimental reactions to ribotoxins and fatal side effects of cancer therapy. However, despite decades of research into the RSR, the physiological relevance of the underlying pathway in whole organisms is unknown. I hypothesize that the RSR constitutes a general translation quality control pathway and hence I aim to uncover the physiological and pathological implications of RSR impairment in mice and nematodes. In one line of investigation, I will elucidate the connections between UV radiation and RSR-mediated p38 activation. I hypothesize that this signalling pathway is critical for sunlight-induced skin inflammation and development of skin cancers of different cellular origins. Rewardingly, we found that cells from our ZAK knockout (KO) mice are refractory to UV-induced p38 activation, which is a significant contributor to skin cancer development. My team has also observed deregulation of protein translation in RSR-deficient human and mouse cells, and a reduced lifespan of ZAK KO nematodes. Thus encouraged, I will determine the impact of the RSR pathway on cancer development and aging processes in mice, and I will unravel the molecular connections between defective ribosomes, RSR activation and regulation of translation. Finally, I am in a unique position to evaluate the RSR as a putative drug target and I will investigate the potential of ZAK inhibition to treat or prevent skin cancer, and to remedy inflammation arising from infection with ribotoxin-producing bacteria. In sum, PHYRIST will yield the first detailed insight into the in vivo relevance of the ribotoxic stress response.

Keywords: cancer,aging,inflammation,skin,ribosomes,protein translation
Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease (LifeTime)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Coordination and support actions
Countries involved: Italy,Israel,Austria,Germany,Germany,Germany,Spain,Germany,Romania,Sweden,Switzerland,Belgium,Greece,Poland,France,Netherlands,Denmark,United Kingdom
Call: Preparatory Actions for new FET Flagships (H2020-FETFLAG-2018-01, 2018)
Start date: 2019-03-01
End date: 2020-06-30
Duration (months): 16.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 20
Project status: CLOSED

Understanding how genomes function within cells, and how cells form tissues and dynamically remodel their activities when tissues progress towards disease is among the grand science and technology challenges of our era. The early detection and interception of chronic and progressive diseases would alleviate enormous suffering and a heavy, growing burden on our economy and ageing society. LifeTime aims to revolutionize healthcare by developing and integrating several emerging, disruptive technologies (single-cell multi-omics, advanced imaging, machine learning/artificial intelligence (AI), organoids, and CRISPR-Cas). LifeTime technologies will track and decipher the activity of our genomes (our "book of life") in individual cells as they progress through time (ageing or disease)-"LifeTime". LifeTime's unifying goal is to quantify, model, and predict cell trajectories in tissues and whole organisms. Its long-term vision is that LifeTime technologies will inform the physician about the molecular history of a patient's tissues, their future, and the consequences of perturbations or medical treatments, leading to early diagnosis and effective interception of disease. LifeTime scientists are world-leaders in the required technologies and are committed to establishing an open and dynamic network. LifeTime's focus on developing, integrating and applying several disruptive technologies will induce long-lasting structural changes in European life sciences and healthcare and establish leadership in AI applications for medicine. Together with many industrial partners, we will develop technologies to redefine diagnosis and pathology, and set new standards for mechanism-based drug discovery and disease management for the 21st century. Such advances and their ensuing medical transformation will significantly impact the health of European citizens and stimulate the economy with tremendous benefit for society as a whole.

Keywords: single cell technologies,multi omics,machine learning,artificial intelligence,organoids,imaging technologies,gene regulation,bioinformatics,precision,personalized medicine,molecular medicine
Targeting Real chemical accuracy at the EXascale (TREX)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Germany,Germany,Italy,Germany,Italy,Poland,Slovakia,Sweden,France,France,Netherlands,Luxembourg,United Kingdom
Call: Centres of Excellence in exascale computing (H2020-INFRAEDI-2019-1, 2019)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 4998847.5
EU funding (EUR): 4998847.5
Participants: 19
Project status: SIGNED

TREX is a highly integrated initiative that gathers most European leading scientists in quantum mechanical simulations of extreme accuracy in the framework of stochastic quantum Monte Carlo methods. This methodology represents one of the highest steps in precision in the ladder of electronic structure approaches and is uniquely positioned to fully exploit the massive parallelism of the upcoming exascale architectures. The marriage of this sophisticated approaches with exascale computing is bound to enable molecular simulations of unprecedented accuracy for complex scientific and industrial applications, meeting the growing demands for robust and predictive calculations in materials design. Thanks to co-design activities with leading high-performance computing (HPC) stakeholders, TREX will deliver a sophisticated product consisting of a user-friendly, high-performance software platform in the domain of stochastic quantum chemical simulations, which will enable the convergence of HPC and high throughput computing (HTC), and which will be made fully available to the computational community in academia and industry. Finally, TREX will work on show-cases to leverage quantum Monte Carlo methods for commercial applications as well as develop and implement software components and services that make it easier for commercial operators and user communities to use HPC resources for these applications.

Keywords: quantum chemistry,materials science,quantum monte carlo methods,exascale,performance optimization,high performance library