Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Death receptor signalling in tumour immune editing (DISCOVER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Ireland,Switzerland,Türkiye,Greece,France,France
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 904500.0
EU funding (EUR): 904500.0
Participants: 9
Project status: CLOSED

During tumour development there is a bi-directional communication between cancer cells and immune cells; the process termed tumour immune editing. The impact is reciprocal, shaping both the visibility and susceptibility of the tumour to immune eradication as well as the ability of the immune effector cells to recognise and launch an immune response against tumour cells. Death ligand-death receptor signalling is a key mechanism to kill tumour cells during the early stages of tumour development (tumour immune surveillance). However, the role of this signalling pathway in evolved tumours is poorly understood. Recent pioneering results from DISCOVER consortium members highlighted non-canonical signal tranduction pathways mediated by death receptors, which regulates both tumour cell behaviour (motility, invasion) and effector immune cell function in the tumour microenvironment. The aim of the DISCOVER proposal is to bring a collaborative research network together to determine the role of death ligand-death receptor signalling in tumour - immune cell interactions. The DISCOVER programme will determine how non-canonical signal transduction pathways driven by death receptors control effector immnue cell functions and tumour cell behaviour. The outputs of the research will be used to develop informed therapeutic strategies to interfere with non-canonical death receptor signalling in order to re-activate anti-tumour immune attack and sensitise tumour cells to this attack. The DISCOVER proposal will integrate the research activity of seven beneficiary organisations from 5 European countries, including 3 companies and create a framework for knowledge and reagent exchange for early stage and experienced researchers. The consortium will bring together scientists from immunology and cancer cell biology and combines these with expertise in systems biology, drug discovery and pre-clinical drug development thus forging a consortium where scientific discoveries drive innovation.

Keywords: death receptor,fas ligand,trail,cell death,natural killer cell
3D integration technology for silicon spin qubits (QUCUBE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-02-01
End date: 2025-07-31
Duration (months): 78.0
Total project cost (EUR): 13990460.0
EU funding (EUR): 13990460.0
Participants: 2
Project status: SIGNED

Originally conceived to describe the microscopic world of atoms and elementary particles, the theory of quantum mechanics has eventually served to predict macroscopic phenomena, e.g. the electrical and optical properties of semiconductors, resulting a wide range of technological applications that have changed our way of living. Foundational properties like quantum superposition and entanglement, however, have remained essentially unexploited. Their use may allow achieving computational powers inaccessible to classical digital computers, opening unprecedented opportunities. In a quantum computer, the elementary bits of information are encoded onto two-level quantum systems called qubits. Since qubits interact with the uncontrolled degrees of freedom of their environment, the evolution of their quantum states can become quickly unpredictable, leading to a reduced qubit fidelity. In topological quantum computing schemes, e.g. the surface code, the reduced fidelity is compensated by using decoherence-free logical qubits consisting of a large number (~103) of entangled physical qubits. As a result, a useful quantum processor should host at least millions of qubits. Although dauntingly large, this number is still small as compared to the number of transistors in a modern silicon microprocessors. QuCube leverages industrial-level silicon technology to realize a quantum processor containing hundreds of spin qubits confined to a two-dimensional array of electrostatically defined silicon quantum dots. To face the challenge of addressing the qubits individually, we use a three-dimensional architecture purposely designed to accommodate, on separated planes, the charge sensing devices necessary for qubit readout, and the metal gate lines for the electrical control and measurement. The gate lines are operated according to a multiplexing principle, enabling a scalable wiring layout. We shall implement fault-tolerant logical qubits and quantum simulations of complex Hamiltonians

Keywords: nanoelectronics,quantum computing,scalability,silicon,cmos devices complementary metal oxide semiconductors devices
Steora - next step to a smart city (Steora)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Croatia
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Steora project envisions future cities as smart social and infrastructural organisms. The aforementioned smartness will be enabled by a number of technologies and devices embedded all around urban fabric. Street benches, as one of the most common elements of urban space, are one of best devices for implementation of new ICT and energy technologies in cities. Steora aims at becoming a cornerstone of implementation of new technologies in open areas in cities. Proposal is related to work programme topic “Stimulating the innovation potential of SMEs for a low carbon and efficient energy system”. Include Ltd’s vision is to become one of the major manufacturers of innovative and useful products worldwide. Company’s mission is to create a product that will solve the various problems through the usage of new technologies mainly reducing energy consumption and carbon footprint by smart and sustainable use (including energy-efficient products and services as well as ‘Smart Cities and Communities’. In order to achieve our purpose, we are primarily engaged in the identification of problems encountered by citizens, companies and institutions as well as the development of solutions that will significantly contribute to the quality of life, lower the CO2 and energy consuption by a smart solution applied to the environment. Steora is a first step towards developing resource-efficient, cost-effective and affordable technology solutions to decarbonise and make more efficient the energy system in a sustainable way by creating modular, independent, integrated and upgradeable devices and technologies applicable in unlimited number of areas.

Keywords: renewable energy system for cities
Development of innovative self-consumption and aggregation concepts for PV Prosumers to improve grid load and increase market value of PV (PV-Prosumers4Grid)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Spain,Austria,Austria,Germany,Spain,Germany,Italy,Belgium,Belgium,Netherlands,Portugal,Portugal
Call: Market uptake of renewable energy technologies (H2020-LCE-2017-RES-CSA, 2017)
Start date: 2017-10-01
End date: 2020-03-31
Duration (months): 30.0
Total project cost (EUR): 2501738.75
EU funding (EUR): 2501738.75
Participants: 13
Project status: CLOSED

The aim of the PV-Prosumers4Grid project is to develop and implement innovative self-consumption and aggregation concepts and business models for PV prosumers that will help integrating sustainable and competitive electricity from PV in the electricity system. The benefits of the PV-Prosumers4Grid action will be therefore threefold: • To identify the necessary regulatory changes and the business opportunities for PV prosumers and grid operators • To further support the deployment PV systems for electricity generation with focus on physical and financial grid interactions • To provide PV Prosumers (households and industries) with competitive and sustainable electricity Innovative self-consumption and aggregation concepts and business models for PV generation are extremely needed nowadays. At the time being many EU Member States have drastically reduced measures to further support the development of the RES sector, even though several projects have clearly demonstrated the need to maintain the policies to support RES until when a consolidated competitiveness has been achieved. Such competetiveness for variable RES will depend on the ability of the existing or future electricity markets to provide them with adequate revenues, whatever the size of the plant. In addition, the variable aspect of PV doesn’t allow them by nature to bid on the market at chosen times, with a possible and already visible impact on the market prices. The consequence could be that under such conditions, their competitiveness will become more difficult to achieve unless the consumers could become more responsive to price signals and allow to displace the load. Moreover, the new state aid guidelines published in April 2014 by the European Commission are pushing for further integration of renewable sources into the electricity markets, which will require from RES to cope with market integration, more constraining grid codes and balancing regulations.

Keywords: self consumption,grid,regulation,support scheme,photovoltaic,solar
Topological Insulator Laser (Topo Ins Laser)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-06-01
End date: 2024-11-30
Duration (months): 78.0
Total project cost (EUR): 1864000.0
EU funding (EUR): 1864000.0
Participants: 1
Project status: SIGNED

Triggered by condensed matter, a new frontier recently emerged: Photonic Topological Insulators (PTIs). These are photonic structures where the transport of light is topologically protected: light propagates in a unidirectional manner without reflection, even in the presence of corners, defects, or disorder. The first step toward PTIs was the electromagnetic analogue of the quantum Hall effect, employing magnetic fields in gyrooptic media. Bringing the concepts of topological insulators into photonics required fundamentally different effects, eluding researchers until in 2013 we demonstrated the first PTI. That, along with experiments in silicon photonics and pioneering theory work, launched the field of Topological Photonics. This proposal aims to explore the possibility of the “next big thing”, a fundamentally new concept, never suggested before in any context, with high potential impact on fundamentals and on lasers technology: we will explore the idea of the Topological Insulator Laser. Topological Insulator Lasers are lasers where the lasing mode is topologically protected: light propagates around the cavity unaffected by disorder and defects. Based on our preliminary studies, we envision that by lasing in a topological mode, the interplay between the topology and gain will lead to a highly efficient laser, robust to defects and disorder, that lases in a single mode even at high gain values. The road to achieve this goes against current knowledge: topological insulators are linear Hermitian closed systems, whereas the topological insulator laser is a non-Hermitian, highly nonlinear, open system. Our study will be theoretical and experimental, starting at the fundamentals of topological transport in systems with gain, and we will take it all the way to experimentally demonstrate the concepts in several different platforms. The idea of the Topological Insulator Laser is unique: success will mark a new milestone in optics and topological physics.

Keywords: topological photonics
Enhance innovation management capacities in Andalusian SMEs. CESEAND InnoAses 2020/2021. (CESEAND InnoAses5)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Spain
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 225597.5
EU funding (EUR): 225597.0
Participants: 4
Project status: CLOSED

The CESEAND InnoAses5 project identifies the Innovation Management Capacities Improvement as a crucial milestone to create more innovative Andalusian SMES, enhance their relation with other potential European partners, reinforce their potential cooperation and increase the cross border activities becoming more and more competitive into the single market. Advance and tailored support into the SMEs Innovation Management Capacities is also needed in order to create a favourable ecosystem for their innovations growth, providing support to research, development and innovation projects, such as specific services aimed to improve their innovation skills and address the financing needs required by the implementation and execution of high-risk and high-potential innovation ideas to markets. This means, as described into the figure below, start analysing which ideas, from a pool of different ones, are able to arrive faster to the market, making more profitable the resources allocated for these projects. The two main objectives of this proposal are to ensure that key SME beneficiaries of H2020 are helped efficiently to fulfil their innovation potential and the innovation management capacity of the SME clients is increased; which contributes to the smart growth of Andalusia, Ceuta and Melilla; through the provision of support services as well as information and advisory services such as mentoring, coaching and partner search activities for SMEs aimed to enhance the innovation management capacities, wishing to develop innovation projects with a strong European or international potential.

Keywords: enhancing innovation management capacities services to sme s in the enterprise europe,network improve innovation health check sme empower sme instrument
Evolution of VEnom Regulation (EVER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2024-04-08
Duration (months): 36.0
Total project cost (EUR): 286724.16
EU funding (EUR): 286724.16
Participants: 1
Project status: SIGNED

Animal venom is a remarkable example of convergent evolutionary novelty - it has independently evolved across all phyla of the animal kingdom to subdue prey and predators. To produce and deliver this potent biochemical weapon, venomous animals possess specialized anatomical structures which emerge from different developmental tissues in the various lineages. How animals have repeatedly evolved this key adaptive trait is unknown. The recent omics revolution has generated an explosion of venom-gland transcriptomes mainly for biodiscovery. However, the mechanisms underlying the emergence and regulatory evolution of venom have not been investigated. In this ambitious and ground-breaking project, I will use a hierarchical approach and large-scale comparative transcriptomic analyses to shed light on the following open questions: Q1) To what extent is the independent evolution of novel adaptive traits associated with convergence in transcriptome evolution? Q2) Which molecular processes contribute to the evolution of these innovative traits? Q3) To what extent does the expression pattern of new specialized cell types overlap the original tissue from which they develop? I will answer Q1 by comparing non-homologous venom-gland transcriptomes across the major lineages of the animal kingdom. I will answer Q2 by focusing on one lineage (Neogastropoda) and comparing the venom-gland with homologous, non-venomous organs. Finally, I will answer Q3 by analysing gene expression patterns between structurally and functionally different cell types within the venom-gland. The success of this project is ensured by the integration in top hosting bioinformatics groups at the Université de Lausanne and collaboration with leading experts in cone snail evolution. This project will provide intensive training which is crucial for restarting my research career and establishing myself as a pioneer and leader in a new research area, venom evo-devo.

Keywords: evolution,evolutionary biology,bioinformatics,regulatory network
Mass loss in the lives and deaths of massive stars (StarlightWinds)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Across our Universe, the dynamics and chemical evolution of spiral galaxies like the Milky Way are primarily controlled by the lives and deaths of stars with masses many times that of the Sun. But the evolution of these massive stars is, in turn, highly regulated by the huge amounts of mass lost from their surfaces, by means of powerful starlight-driven winds. These stellar winds critically determine how such massive stars evolve through their lives, and how they finally die in giant supernova explosions. However, due to the very large quantitative uncertainties associated with this mass loss, present-day predictions for such massive-star evolution are seriously flawed. The overarching goal of this ambitious project is to fundamentally improve this situation by using novel methods to develop new models of radiation-driven winds from hot, massive stars. Combining state-of-the art numerical NLTE radiative transfer and hydrodynamics with innovative analytic techniques and theory development, the applying researcher proposes to 1) develop new, drastically improved wind models from main-sequence massive stars, and 2) simulate the winds of the most massive stars known in the Universe as well as design the very first general predictive theoretical framework for the wind driving and mass loss from evolved Wolf-Rayet stars. By furthermore examining the effects of the new mass-loss rates on models of stellar evolution, and carefully comparing the new simulation results with observations, this project will fundamentally improve our knowledge of the basic wind-physics of massive stars, as well as significantly contribute to our understanding of the evolution and ultimate fates of these stars. Indeed, the results expected during the fellowship will undoubtedly form the building blocks of many future scientific projects, allowing then for further progress also in the large number of research fields relying on a firm understanding of the lives and deaths of massive stars.

Keywords: astrophysics,massive stars,mass loss,stellar winds and outflows,stellar evolution,stellar atmospheres,radiative transfer,hydrodynamics
Development of high-quality crystalline silicon layers on glass (cSiOnGlass)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The objective of this project is the development of high quality poly silicon (poly-Si) thin films on glass applying liquid-phase crystallization by line focus laser irradiation. Introducing an adequate interface layer between the glass and the silicon film and applying laser crystallization by scanning over thin amorphous or nano-crystalline silicon thin films on glass has been shown to yield high-quality poly-Si films for solar cells. These films on glass present also high potential for other electronic devices like e.g. flat panel displays. In photovoltaic (PV) application this technology could result in significant silicon material savings and therefore cost reduction of PV modules in the near future. In the electronic industry it could give new possibilities to fabricate highly integrated electronic circuits on large area. In the frame of this project the investigation and optimization of the laser crystallization process and the design of the interface layer either for low cost soda-lime float glass or ultra-thin high temperature glass will be a focus. Solar cells and mini modules will be fabricated with the aim to develop on the one hand a process technology for large area monolithic integrated poly-Si thin film modules and on the other hand low cost wafer equivalents for back contacted solar cells which on the long-term can achieve efficiencies of multi-crystalline wafer cells. For characterization and analysis of the electronic and optical properties of the glass/poly-Si substrates and solar cells injection level dependent photoluminescence and spectral response measurements will be further developed and implemented.

Keywords: solar cells,liquid phase crystallization,silicon thin film,photoluminescence,spectral response