Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of a new generation of bioengineered bandages (PHAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Skin wounds are of major causes for global disease burden, affecting millions of people worldwide. Furthermore, over half of skin wounds become infected, which is a major limiting factor for recovery, especially after severe burns. Indeed, because of modern resuscitation procedures, burn patients usually survive the initial trauma and it is the burn wound infection that remains the major cause of mortality and healing delay. This is particularly true for severely burned patients for whom immediate wound closure is not possible, leaving them for very long periods of time non-grafted. Treatment is associated with prolonged hospitalizations and significant costs, without mentioning the severe pain, emotional and physical strain that the burn trauma inflicts to the individual affected. We propose here to develop a novel bioactive skin substitute to cope with the burden of infections, and thus align with the World Health Organization’s strategic plan for effective and sustainable burn prevention and care policies. As the ultimate aim is to translate the novel approach in regenerative medicine from bench-side to bedside, I will engage in the frame of this action a synergistic endeavor with several actors of their respective field, to boost the research and meet the imposed regulatory requirements for the introduction of new treatments into clinics, as well as to use cutting-edge techniques such as metagenomics and MALDI-TOF to determine the temporal diversity and evolution of microbial communities for various burn patient cohorts.

Keywords: biological bandages,antimicrobials,burn wounds,skin microbiota
Quantum hyperpolarisation for ultrasensitive nuclear magnetic resonance and imaging (HyperQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Denmark
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-07-01
End date: 2026-06-30
Duration (months): 72.0
Total project cost (EUR): 9374860.0
EU funding (EUR): 9374860.0
Participants: 2
Project status: SIGNED

Many of the most remarkable contributions of modern science to society have arisen from the interdisciplinary work of scientists enabling novel methods of imaging and sensing. Outstanding examples are nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) which have enabled fundamental insights in a broad range of sciences extending from Chemistry to the Life Sciences. However, the key challenge of NMR and MRI is their very low inherent sensitivity due to the weak nuclear spin polarisation under ambient conditions. This makes the extension of magnetic resonance to the nanoscale (small volumes) and to the observation of metabolic processes (low concentrations) impossible. HyperQ will address this challenge with the development of room-temperature quantum control of solid-state spins to increase nuclear spin polarisation several orders of magnitude above thermal equilibrium and thereby revolutionise the state-of-the-art of magnetic resonance. Essential for this development is the synergy of an interdisciplinary team of world leaders in quantum control and hyperpolarised magnetic resonance to enable the development of quantum control theory (“Quantum Software”), quantum materials (“Quantum Hardware”), their integration (“Quantum Devices”) and applications to biological and medical imaging (“Medical Quantum Applications”). HyperQ will target major breakthroughs in the field of magnetic resonance, which include chip-integrated hyperpolarisation devices designed to operate in combination with portable magnetic resonance quantum sensors, unprecedented sensitivity of bio-NMR at the nanoscale, and biomarkers of deranged cellular metabolism. The HyperQ technology will provide access to metabolic processes from the micron to the nanoscale and thereby insights into metabolic signatures of a broad range of disease such as cancer, Alzheimer and the mechanisms behind neurodegenerative disease. This will enable fundamentally new insights into the Life Sciences.

Keywords: nuclear magnetic resonance,magnetic resonance imaging,hyperpolarisation
Pre-commercial Procurement of innovative ICT-enabled monitoring to improve health status and optimise hypertension care (HSMonitor)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Pre-Commercial Procurement
Countries involved: Italy,Italy,Spain,Germany,Croatia,Sweden,Türkiye
Call: Digital health and care services (H2020-SC1-DTH-2018-2, 2018)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 6592200.0
EU funding (EUR): 5932980.0
Participants: 10
Project status: SIGNED

5 public procurers from 4 countries will procure innovative ICT-enabled monitoring solutions to improve health status and optimise hypertension care. HSMonitor will make person-centred care reality - giving the patient the steering wheel - for optimal health outcomes. The procurers have set a comprehensive framework for requirements and solution design consisting of 9 building blocks in three domains, to be addressed in an integrated ICT-enabled hypertension care solution. HSmonitor will apply the internationally acclaimed Chronic Care Model to specify support needs for hypertensive patients at all stages. Self-management and treatment will be supported by personalised guidelines and making the best use of clinical data. In this way a quality culture in healthcare will be fostered and learning healthcare systems made reality. Suppliers will be rigorously evaluated after each of the procurement phases, comprising (I) an open market consultation, (II) specification of architecture and system aligned to requirements of patients, peers and providers, (III) prototype development and testing with end-users and (IV) effectiveness proven in a trial with 500 patients and 150 professionals. Fully rolled out in the procurer countries, enabled by procurers with the authority and capacity in their countries and regions, HSMonitor will serve 31 million patients with hypertension. Reductions in hypertension-related complications promise cost relief of € 5 billion over 7 years in the five procurer countries. Suppliers can expect a turnover of € 1 billion a year. Proven ability to cover the four different health systems promises HSMonitor suppliers easy entry into other EU markets and beyond, a very strong contribution to overcoming fragmentation of demand and fostering the global market.

Keywords: hypertension,monitoring,innovation
Bringing automated, real-time process control into the starch-based industry (ENZEYE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-03-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The enzymatic process of extracting the starch from cereals and breaking it into fermentable sugars is called mashing. Today there are no analytical tools available at industrial facilities providing real-time information on the concentration of sugars and their degree of polymerisation. In consequence it is not possible yet to monitor and optimise in real time the mashing process, which will indeed determine the outcomes of large industries such as beer, food ingredients and bio-ethanol production. At Specshell we have seized this opportunity and developed ENZEYE, the first control system to provide continuous and real-time information on the degradation of starch and the formation of sugars throughout the mashing process. Our uniqueness is based on (1) the adaptation of mid-IR technology to the industrial setting, which enables for the first time to identify the dissolved species directly as the product flow, and (2) our proprietary chemometrics libraries, converting in real-time the IR-absorption spectra data into parameters of interest for plant operators. The first version of our product has been implemented in different industrial breweries and reported savings amounting €1million annually to each plant, thanks to a smarter dosage of raw materials and enzymes, improved temperature control, and increased conversion yields. Our first target market is the brewing sector: we aim at benefiting them by facilitating the optimisation of their resources and enable them to produce small batches of beers in a fast manner and immune to fluctuations of raw materials’ quality. In addition, ENZEYE will be introduce in the bio-ethanol sector and become a key enabler in helping Europe to become the leader in the widespread implementation of the second generation of bio-ethanol production. ENZEYE will positively impact our company reporting revenues surpassing the €45 million in the 3rd year after market uptake, and enabling the creation of up to 35 new positions.
Efficient filtering of metallic impurities in food processing (Magnesys)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In food processing like in the case of flour mills but also other powder type materials, the contamination by metallic impurities is a problem. Today`s magnetic filters do not satisfying in term of efficiency and cleaning costs. Bullet magnets that are state-of-art of the filter technology are expensive to operate because of the high electric consumption. MagneSys developed and tested HGF , a novel patent pending magnetic filter for food processing that allows the continuous filtering-out of iron magnetic particles from various solid foods in dry powder form such as flour for example.
Projecting migration from Africa and the Middle East into EU countries, driven by climate-change-related crop failure, until 2050 (ClimateMigration2050)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The increase in migration into EU member countries in 2015, and the socio-political challenges associated with it, have led the EU to set out a strategy to tackle root causes of irregular migration in the countries of origin. Crop failure caused by climate change, in particular, is forecast to be a major driver of international migration in the coming decades. In this project, we will integrate state-of-the-art climate, crop, economic and migration models in order to predict potential migration flows, driven by climate-change-related crop failure, from African and Middle Eastern countries into EU member states until the year 2050. We go on identify optimal adaptation strategies in countries at risk, which can stabilise agricultural production and help minimise future migration pressures. By using multi-model projections, and performing in-depth model uncertainty and sensitivity analyses, we will generate robust projections driven by the best data available, and ensure a transparent assessment of uncertainties. Our results will inform evidence-based action by EU policy makers aimed at minimising future large-scale forced migration driven by climate change. This highly interdisciplinary project will give the Experienced Researcher the opportunity to complement his background in agro-environmental modelling, by developing expertise in the socio-economic dimensions of global food production under climate change. Home to world-leading experts of all disciplines relevant to the project, and exceptionally well connected with national and international governmental and non-governmental bodies, both the Host Institution (Potsdam Institute for Climate Impact Research) and the Secondment Host Institution (International Organization for Migration) will provide a unique environment for ensuring the highest-quality research and training during the fellowship, as well as the effective communication of results to EU policy makers and the wider public.
Role of cell membrane associated Hsp70 in cancer cell adhesion and metastasis (HspAdhesion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

We propose an interdisciplinary project at the interface of biophysics, biochemistry, and medical research. Our objective is to investigate the specific role of cell membrane associated heat shock protein 70 (Hsp70) in the context of invasive cancer. In particular we address the question how cell membrane localization of Hsp70 affects differential adhesion of cancer cells and the formation of metastasis. In general, heat shock proteins (HSP) assist in folding of nascent proteins, prevent protein aggregation, and assist transport of proteins. Upon a variety of stresses HSP production is rapidly upregulated. Hsp70 is the major stress-inducible member of the HSP70 family. In normal cells it copes with harmful unfolded and denatured protein conferring protection to the cell. Tumor cells frequently present Hsp70 on their outer surface where it exhibits additional activities. For a number of different tumors a high level of membrane Hsp70 has been found to indicate drastically decreased survival chances in patients. Moreover it has been implicated in formation of metastasis where it might support spread and anchoring into distant tissues. These findings highlight the clinical significance of cell membrane associated Hsp70 and the need for a better understanding of its role in differential cell adhesion and progression of cancer. We will employ atomic force microscopy (AFM) in order to elucidate the function of membrane Hsp70 as a possible adhesion molecule or mediator of cellular adhesion. (1) Using single-cell force spectroscopy we will characterize and quantify adhesion forces of Hsp70 positive and negative cells to different substrates mimicking their interaction with extracellular matrix and host tissue. (2) With the help of a specialized AFM technique that enables topography imaging with a simultaneous recognition of specific surface molecules we will determine the localization and arrangement of Hsp70 molecules on the cell surface with nanometer resolution.

Keywords: atomic force microscopy,force spectroscopy,recognition imaging,cell adhesion,cancer,exosomes
A Compact Terahertz Trace Gas Detector (TeraTrace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

A near-spherical terahertz resonator will be constructed and integrated into a mobile terahertz trace gas detector. It will deliver about two orders of magnitude larger terahertz path lengths, corresponding to trace gas detection sensitivity down to one part per million. With this a means becomes available to measure trace gases that are very difficult to monitor by standard means, such as the atmospherically important hydroxyl radical.

Keywords: terahertz spectroscopy,trace gas detection
Transforming Cellular Network Data Into the Next Generation of Mobility Management Platform (TrafficWise)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Israel
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2019-03-31
Duration (months): 31.0
Total project cost (EUR): 1635617.5
EU funding (EUR): 1144932.25
Participants: 1
Project status: CLOSED

Transportation authorities use real-time traffic data for everyday urban transport management, and analyse commuters’ origin and destination points for infrastructure and transit planning. However, intelligent transport systems that provide real-time data cost millions of euros for road sensor deployment. GPS aggregators like Google Maps and Inrix are inexpensive but can miss up to 50% of real time traffic jams, and do not represent population segments proportionally, which is essential to transportation planning. Cellular network location data is now ubiquitous and cheap, but it is imprecise due to the range of cellular antenna coverage. Cellint uses artificial intelligence algorithms to process cellular network location data for optimized transportation management. Our patented technology tracks phones on a mobile network passively and anonymously, pinpointing their locations on any mode of transportation. The result is a virtual sensor network that provides real-time sensor-quality traffic data at a fraction of the cost of sensor systems. Our origin-destination data is so accurate that it can identify the root causes of specific transit congestions. Our technology is unparalleled in its performance and cost-effectiveness. However, we manually process the data that our transport authority clients require. Preparing customized reports based on this comprehensive data can take weeks or months. This has created a serious bottleneck for us, and is restricting our growth. In this project we will upgrade and integrate our current solutions into a single automated transportation information platform with advanced analysis and visualization features, with results provided in minutes instead of months. We will launch 4 modules: 1) Real-time traffic management, 2) Ongoing transportation management, 3) Real-time crowd management, and 4) Parking management. TrafficWise will be the first holistic, low-cost, highly accurate transportation information platform in the world.

Keywords: smart transportation management,infrastructure planning,cellular location data,artificial,intelligence algorithms
Cellulose Aluminium Polymer multi-ions composite Solid-electrolyte (CAPSEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

A low cost and efficient cellulose aluminium polymer multi-ions solid electrolyte (CAPSEL), with ionic conductivity in the range of 1-3 mS/cm, has been produced by a simple process which enables thin and large area battery production. An electrolyte with inherent potential towards Al based batteries and posterior commercialisation. CAPSEL may represent a good alternative to Li based batteries as Al is an abundant, cheaper and less reactive metal compared to Li. The formulation of CAPSEL can be easily adapted to other ions, such as Na and Li. Furthermore, a solid electrolyte can solve many of the safety risks existing in commercially available batteries, in addition to allowing a significant reduction in their size and weight. We expect this project to give an important contribution towards a new class of highly efficiency batteries whose disposal route offers no environmental impacts. This is only possible because of its biodegradable polymeric binder and cellulose as major constituents of the electrolyte. Therefore, CAPSEL can follow conventional recycling routes of paper after the batteries' end-life cycle. CAPSEL also enables the power supply of low-cost and large area disposable applications like e-paper, smart labels and smart packing. The Proof-of-Concept is a unique opportunity to focus on further exploitation of the developed solid electrolyte whilst at the same time concentrating efforts towards the compilation of a suitable product data sheet verified by an independent laboratory - a crucial step prior to engaging with potential investors/partners for either production or commercialisation.

Keywords: solid electrolyte,aluminium ions,high conductivity,temperature stability,low cost,simply process,environmental friendly