Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advancing the Scalability and Performance of I/O Subsystems in Multi-core Platforms (IOLANES)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Greece,Spain,Spain,Israel,Ireland,Greece
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2013-03-31
Duration (months): 39.0
Total project cost (EUR): 4260842.0
EU funding (EUR): 2718000.0
Participants: 6
Project status: CLOSED

Data storage technology today faces many challenges, including performance inefficiencies, inadequate dependability and integrity guarantees, limited scalability, loss of confidentiality, poor resource sharing, and increased ownership and management costs. Given the importance of both direct-attached and networked storage systems for modern applications, it becomes imperative to address these issues. Multicore CPUs offer the promise of dealing with many of the underlying limitations of today’s I/O architectures. However, this requires careful consideration of architectural and systems issues and complex interactions in the I/O stack, all the way from the application to the disk. In this proposal we target three major challenges: (i) dealing with performance and scalability issues of the I/O stack on multicore architectures, (ii) addressing I/O performance and dynamic resource management issues in virtualised, single-host environments, and (iii) examining on-loading and off-loading tradeoffs for advanced functions that are becoming essential in modern storage systems, e.g. compression, protection, encryption, error correction; on-loading uses free cores of multicore CPUs, whereas off-loading uses specialized architectural features, such as heterogeneous units. This project aims at analyzing and addressing these challenges throughout the I/O path. Our approach breaks down the I/O stack in four important layers: (a) application and middleware, (b) virtual machine, (c) host operating system, and (d) embedded storage controller. The proposed work analyzes and addresses the inefficiencies associated with these layers on multicore CPUs, by designing an I/O stack that minimizes unnecessary overheads and scales with the number of cores. Since storage systems are perhaps the most critical component of modern computing infrastructures, the proposed work will benefit many I/O-intensive applications that support activities of businesses, organisations, and individuals alike.

Keywords: operating system multicore cpus i/o performance i/o virtualization networking,storage i/o intensive applications
Functional implications of the remarkable conservation of eukaryotic gene architecture (FUNCTIONARCHITECTURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

One of the fundamental principles in comparative genomics is that evolutionary conservation implies functional importance. This principle has been used extensively in the life sciences, as a tool to detect biological functionality. In the vast majority of studies, evolutionary conservation has been sought in three biological “entities”: sequence (actual nucleotide or amino-acid sequences, as well as sequence properties like codon usage bias, GC content, and amino-acid bias); structure (like RNA, DNA and protein secondary and tertiary structures); and genome architecture (like synteny, gene order, relative gene orientation). These strategies have worked very well, but evidence is rapidly accumulating that there is a lot of “function without detectable conservation”. Many factors can potentially contribute to such “undetected functionality”, such as functions that do not depend on sequence or structure (for instance, nonsense mediated decay is affected by the mere location of the introns), functions that depend on very short and redundant sequence motifs, co-evolution of factor and target, and migration of functional sequences along the chromosome. We suggest a novel strategy to identify parts of these “undetected functions”. We study how to quantify the conservation in a fourth type of biological “entity”, that we dub gene architecture, and which is derived from the exon-intron structure of the gene. To this end, we are building a eukaryotic gene architecture database, and developing an algorithm to quantitatively evaluate the level of architectonic conservation in the different regions of the gene. Preliminary analysis reveals that conservation of gene architecture is plentiful, and in many cases it can be detected over very long evolutionary times (more than a billion years). This allows us to identify genic elements, mostly introns and splice junctions, which are likely to be of functional importance.

Keywords: computational biology,evolutionary biology,genomics,molecular evolution
BIOACTIVE SERINE PROTEASES FROM HUMAN PARASITE SCHISTOSOMA MANSONI (SCHISTOSOMA PROTEASE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia,Czechia
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Schistosomiasis caused by trematode parasites, the Schistosoma bloodflukes, represents one of the most serious chronic infections in the developing world with more then 200 million people infected and many more at risk. Schistosomes reside in the portal and mesenteric or bladder and survive for many years producing hundreds of fertilized eggs per day. Chronic infections can persist for decades and severe morbidity results from host immune responses to eggs in tissues. Disease symptoms include; spleno- and hepatomegalies due to an immune-mediated entrapment (granulomas) of schistosome eggs, periportal fibrosis, portal hypertension, urinary obstruction, bladder carcinoma, sterility, malnutrition, developmental retardation. Resistant isolates of S. mansoni in some regions have been already reported from treated patients. Their evasive and immuno-modulatory strategies are key players in host-parasite interactions. Their bioactive molecules involved in these processes represent interesting subject for pharmacology. One group, proteases function at the host-parasite interface facilitating migration, immune evasion and digestion of host proteins. Besides of relatively well characterized enzymes there are groups of proteases which were surprisingly neglected. One of them is a group which belongs to the class of serine proteases, Clan PA trypsin-like family S1. These schistosomal proteases share similarities to several human regulatory factors such as mammalian kallikrein, epithelial transmembrane proteases, protein C-anticoagulation factor. This probably arose due to co-existence with the mammalian hosts and needs to actively interact with their physiological processes involving proteolysis (anticoagulation, vasodilatation, immuno-evasion). If hypothesis is valid, proteases may represent attractive bioactive pharmacokinetic molecules for further research. At last, it may have impact on better understanding of diseases, leading subsequently to new disease treatments.

Keywords: health sciences,protease,proteolytic enzyme,schistosoma mansoni,schistosomiasis,protein expression,helminth infection
Enhanced patient safety by computational Modelling from clinically available X-rays to minimise the risk of overload and instability for optimised function and joint Longevity (MXL)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Towards sustainable and personalised healthcare
Action type: Collaborative project
Countries involved: United Kingdom,Germany,Netherlands,United Kingdom,France,Netherlands,Italy
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 4965588.0
EU funding (EUR): 3700000.0
Participants: 10
Project status: CLOSED

Osteorthritis (OA) is a disabling disease, affecting the joints of 40% or more of the population over 60, resulting in a socioeconomic burden of €7b. per year in Germany alone. Joint surgery attempts to address the various disease stages, to either minimize the risk of early degeneration of the native joint, or to replace a fully degenerated joint, with well over 1,000,000 surgeries performed annually in the EU. Adequate joint function and longevity are the most important factors that define success, yet at least 10% of reconstructions fail within 10 years of surgery, and a large fraction of native joints progresses to early OA. The ensuing revision surgery is not only painful and stressful for the patient but also costly for the health care providers. Joint failure is a consequence of inadequate competence of the patient’s musculoskeletal system, joint overload and instability, or their combination. Currently, surgeons rely on 2D static radiographs and their experience to plan the procedure. To prevent failures and improve outcome, key facts on the mechanical conditions of the joint need to be available to the surgeon. By implementing refined image reconstruction, biomechanical modelling and analysis tools, MXL will make the dynamic joint loading and stability accessible for the planning of joint surgery in every case. Based on this technology, MXL safeguards the patient by supporting the surgeon to decide when to operate, which procedure to use, and which key aspects to address to reduce the failure rate and improve the functional outcome of joint surgery. Therefore, we will develop an ICT based planning environment that provides the surgeon with quantitative information on the patient’s anatomy, the competence of the soft and hard tissues, and integrates them within biomechanical models to arrive at an optimal strategy for joint surgery. This will result in a breakthrough with tremendous effects on patient safety and the return of function and joint longevity.

Keywords: biomechanics,computational,joint replacement,surgery,modeling
Patient Centric Approach for an Integrated, Adaptive, Context Aware Remote Diagnosis and Management of Cardiovascular Diseases (BRAVEHEALTH)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Towards sustainable and personalised healthcare
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Finland,Poland,Portugal,Belgium,Netherlands,United Kingdom,China,United Kingdom
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 29.0
Total project cost (EUR): 10382905.0
EU funding (EUR): 6999546.0
Participants: 18
Project status: CLOSED

BRAVEHEALTH proposes a patient-centric vision to CVD management and treatment, providing people already diagnosed as subjects at risk with a sound solution for continuous and remote monitoring and real time prevention of malignant events. The solution proposed will be made up of the following sub-systems: 1)WEARABLE UNIT: it is an innovative concept of miniaturised multi-parameter sensor, able to continuously monitoring the most critical parameters needed to perform a thorough diagnosis by means of specific diagnostic and prognostic algorithms running on it. It will be possible both to perform scheduled analysis of critical parameters and to remotely trigger the screening of specific vital signs. 2)REMOTE MANAGEMENT UNIT: it represents the main interface between physicians and the system, providing both automated support, in the form of text messages with information or suggestions to the patient directly generated by the system, and doctor managed supervision, allowing direct communication with the patients with voice/text/chat messages. The most important added value of the this unit is the possibility to be interfaced with existing National Health Records and Physiological Data Banks in order to generating and verifying risk prediction models using advanced data mining approaches. 3)LIFE! GATEWAY: Data acquired by the wearable unit will be relayed to a gateway which represents the means by which the information flow from the user to the Central Supervision Unit. This unit will provide the user with the following functionalities: a)Real time communications: in case of anomalies, or simply to suggest specific drugs to be taken, or to advice some particular activity to be performed; 2)Location aware information, exploiting the positioning capabilities of GPS. 3)Mobile virtual community for education and support.

Keywords: cardiovascular diseases,remote monitoring,e-health,wearable diagnostic,decision support system,mobile virtual community.
Multi Purpose Mobile Robot for Ambient Assisted Living (FLORENCE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for Independent Living, Inclusion and Governance
Action type: Collaborative project
Countries involved: Netherlands,United Kingdom,Germany,Spain,Spain,Spain,France,Netherlands
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-02-01
End date: 2013-01-31
Duration (months): 36.0
Total project cost (EUR): 5554933.0
EU funding (EUR): 3550000.0
Participants: 10
Project status: CLOSED

Due to increasing mobility and the ageing society the demand for care will increase significantly, leading to high costs and unrealistic manpower demands. Florence will alleviate this by keeping elderly independent much longer by providing care and coaching services, supported by robots. This will greatly improve the efficiency in care and reduce costs. The second problem addressed by Florence is the acceptance of robots by elderly. For this purpose the project adopts a user-centric approach, by starting with focus-group sessions, having lab-tests in the OFFIS IDEAAL lab, and finally evaluating the services in the Granada AAL living labs. The Florence consortium contains partners from the complete value chain: robot vendors, care providers, and consumer electronics vendors. The consortium positions the service robot as a consumer device, supporting various lifestyle services. In particular the following services will be evaluated in the project: * Social Connectedness: provide access to the social networks, including web-2.0 and synchronous communication tools * Coaching: give feedback on specific activities like physical exercises, and advise on activities of daily life * Care support: log care-related activities at home that are shared among professional or volunteer caretakers. * Safety: use the robot as additional ears and eyes in comfort or safety situations, controlled by service providers or the elderly users. In order to support this multitude of services, the Florence system is based on a service-oriented architecture that provides programmatic interfaces towards the (interaction) capabilities provided by the robot, the home, and remote service providers. Such integration will effectively turn the Florence system into a generic platform for home-services, integrating an autonomous robot with the smart home.

Keywords: living lab,user-centered design,sensor information fusion,service robots,lifestyle services,aal services
Programming for Future 3D Architectures with Many Cores (PRO3D)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: France,France,Switzerland,Italy
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 3542773.0
EU funding (EUR): 2617000.0
Participants: 6
Project status: CLOSED

The shift from systems-on-chip (SoC) to manycore architectures brings new hardware and software challenges ranging from seamless integration of processors, memories the design of modular systems and application software to run on massively parallel and scalable platforms. Manycores will benefit tremendously from 3-dimensional (3D) integration technology that enables distribution in space of computational and storage functions to achieve unprecedented performance levels. PROD3D is an ambitious high risk and high reward project that builds upon existing European world-class R&D expertise of the partners. PRO3D will innovate in both hardware and software technologies and demonstrate the effectiveness of manycores by an integrated and concerted effort in key aspects of hardware and software design. The uniqueness of this proposal stems from the experience of the partners in various aspects of manycore design that need to be addressed concurrently. The key outcome of PRO3D will be a holistic system design methodology to bring a drastic improvement of productivity to reduce cost development and time to market for future embedded computing. In particular, PROD3D will: i) develop a system software flow that can operate transparently on parallel manycore platforms; ii) develop formal methods for software design guaranteeing the composability and correct operation of both Hardware and software; iii) explore the impact of 3D integration for new computing architectures iv) Extend the software-flow to 3D-stacked manycores. The PRO3D consortium brings together world-class leaders in their own field with competencies to cover software, architecture and 3D integration. One of the key differentiators of the PRO3D consortium is its access to an industrial many core System on Chip, named "Platform 2012" and provided by STM. The industrial impact of PRO3D is potentially high since re-search outcomes will be directly exploitatable into STM product roadmaps.
COntent Mediator architecture for content-aware nETworks (COMET)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Cyprus,Poland,Greece
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2013-03-31
Duration (months): 39.0
Total project cost (EUR): 5116268.0
EU funding (EUR): 3259365.0
Participants: 6
Project status: CLOSED

In recent years there has been a growing proliferation of user-generated Internet content. This increasing trend has led to an abundance of intermediaries (e.g. YouTube, Flickr, BitTorrent, etc.) which is expected to grow in the future with massive live content generation (e.g. TV channels, SopCast, etc.) The problem is that, currently users need to know the content location a priori and content has to be typically searched through the relevant intermediary. As a result, a lot of content tends to be accessible only by particular user communities. The COntent Mediator architecture for content-aware nETworks (COMET) will take a unified approach to content location, access and distribution, irrespectively of the intermediary used. COMET will introduce a global naming scheme and will optimise both content source selection and distribution, by mapping the content to the appropriate network resources based on transmission requirements, user preferences, and network state. Content and network-aware mapping will consider current, evolutionary and revolutionary network approaches. The architecture will address two key aspects: a) Global content naming and addressing, with supporting infrastructure for search and content name resolution to the relevant identifiers required for access, and b) unified access and user-, content- and network-aware distribution by mapping the content onto the appropriate network resources through supporting infrastructure, providing content- and network-aware access to every type of content through all possible types of distribution. The COMET content plane aims at becoming a global QoS-aware unified content access mechanism, essentially a content-wrapper around the Internet that shields the user from access details. The COMET project will identify relevant requirements, draw a complete architecture, research and specify required mechanisms, build prototypes, conduct validating experiments, and demonstrate the COMET content plane operation.

Keywords: content awareness,content routing,qos,unicast,multicast,anycast,p2p,streaming,multimedia,edge computed routing,ecr,next generation internet,ngi,future internet,prototype,demonstration
Complex Systems for an ICT-enabled Energy System (COMPLEXENERGY)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Coordination and support actions
Countries involved: Spain,Italy
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2009-11-01
End date: 2011-01-31
Duration (months): 16.0
Total project cost (EUR): 193200.0
EU funding (EUR): 170500.0
Participants: 2
Project status: CLOSED

The European Energy Policy aims at achieving three core objectives: sustainability, competitiveness and security of supply. The achievement of these objectives requires a profound transformation of the energy system that will imply a huge and coordinated effort across several areas. This effort must rely on a sound analysis of different policy approaches, regulatory measures and technological choices. ICT must play a key role as one of the enablers of the energy system transformation, but also as an enabler of new advances in the modeling, analysis and governance of the system. The energy system is a clear example of a large-scale sociotechnical system composed by a myriad of heterogeneous elements working at different scales. The complex behaviour that emerges from these interactions drives classical modeling methods to their limits. Complex Systems Science is emerging as a discipline capable of offering new methods for a realistic, robust and flexible modeling of such kind of systems. New tools such as Agent-Based Simulation or Complex Networks have led to valuable results in several fields, but their application to the energy system still faces a number of open issues that require further research. ComplexEnergy is a support action whose purpose is to bridge the ICT, Energy and Complex Systems research communities in order to: - build the foundations for a new, EC-scale, interdisciplinary research community able to formulate innovative approaches to energy system modeling, design and governance; - carry out a well-defined and systematic consultation of these three research communities, as well as of policy makers and other relevant stakeholders, with the aim to identify the main strategic areas, the emerging research avenues and the major research challenges at the junction of ICT, Energy and Complex Systems; and - define a roadmap for the development of these research trends, including recommendations on research topics for FP7 calls in 2011 and beyond.

Keywords: energy,electricity,grid,network,market,ict,complex systems,abm,complex networks,modelling,simulation,control,optimisation,governance,research topics,roadmap,fet.