Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Guided (Ultra)sonic Waves for High Performance Deepwater Pipeline Inspection (VERNE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy,Norway
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-11-01
End date: 2020-02-29
Duration (months): 28.0
Total project cost (EUR): 2158537.5
EU funding (EUR): 1510976.25
Participants: 2
Project status: CLOSED

This project aims to develop and commercialise VERNE: A non-destructive testing (NDT) system that has the potential to revolutionise underwater inspection of tubular structures by achieving far greater inspection speed and precision compared to existing systems. As the majority of offshore Oil and Gas extraction assets have already exceeded their design lifetime, the need for decommissioning and/or substituting these assets becomes increasingly pressing. However, associated costs are enormous and it will cost nearly €20 billion over the next 10 years to remove around 80 platforms and their associated infrastructure. As asset owners strive to prolong asset lifetime while and minimise risk of catastrophic accidents, the greatest challenge is the inspection and maintenance of subsea structures like jacket foundations and pipelines. In underwater environments the high pressure, seawater and marine life (biofouling) obstruct maintenance operations and accelerate structure degradation. Subsea inspections are currently performed using Remotely Operated Vehicles carrying a payload of cameras, sensors and other equipment. VERNE will dramatically improve on their performance by combining ultrasound and acoustic testing that enable (i) the rapid scanning and defect mapping in a 100m radius around the inspection point and (ii) detailed and precise characterisation once defects are identified. VERNE’s technologies enable inspection of both external and internal surface of structures (e.g. pipelines) without the need to remove anti-corrosion coatings and/or biofouling. As such, VERNE will lead to significant cost savings for asset owners while providing a key competitive advantage to subsea service providers. As such, project partners Dacon and Nardoni anticipate a cumulative turnover of €31.468 million and profits of €19.3 million by Year 5 with a breakeven over the total budget in Year 2 and a ROI rate of 13:1 on EC’s grant.

Keywords: subsea non destructive testing ndt,long range ultrasonic testing lrut,electromagnetic acoustic testing emat,offshore oil and gas
Separation, fractionation and isolation of biologically active natural substances from corn oil and other side streams (EXCornsEED)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Spain,Italy,Germany,Switzerland,Belgium,Slovakia,Romania,Belgium,Slovakia,Netherlands
Call: Proteins and other bioactive ingredients from side streams and residues (H2020-BBI-JTI-2017, 2017)
Start date: 2018-06-01
End date: 2023-02-28
Duration (months): 57.0
Total project cost (EUR): 7065843.75
EU funding (EUR): 4259297.0
Participants: 14
Project status: CLOSED

The EXCornsEED project aims to exploit the convergence between science, chemistry, biology, engineering and biotechnology tools for the creation of new knowledge and innovative applications, with the main goal to develop and validate an integrated process of innovative and highly sustainable extraction/purification/concentration technologies to be applied to bio-refineries side streams (i.e. corn oil, thin stillage from bio-ethanol and rapeseed meal from biodiesel production) for the recovery of proteins and several other bio-active compounds (i.e. polyphenols, amino acids, fibers, lipid compounds, alkaloids and tannins, etc.) and characterization/preparation of these as ingredients for food, specialty chemicals, and cosmetics markets. A three-step approach will upscale the EXCornsEED process from lab level (few grams, TRL3) up to industrial pilot in ENV premises (1t/d capacity, TRL5). The project stems from a sound industrial vision set by ENV and other industrial partners to transform traditional bioethanol production in future biorefinery concept, fully in line with EU strategies for a bio-based economy. The concurrent presence of biotech producer ENV (project initiator) technology experts SAP, CEL and ICE, and product companies SIAL, NUT, BZN and DRL will guarantee the commitment towards a real market-driven project. A synergistic approach will be used with the collaboration of other partners CREA, CTA, INNEN, HC and TEC, in order to define a self-sustainable system and have an outcome that is in accordance with the principles of the circular economy.

Keywords: valorization,corn oil,thin stillage,rapeseed meal,proteins,bioactives,characterization,upscale,cosmetics,food,specialty chemicals,market validation
SyrinJector, the first smart device for livestock mass vaccination. (SyrinJector)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Farm animals are susceptible to different diseases caused by bacteria, viruses, fungi and parasites, just like people. Vaccination protects the welfare of livestock by preventing or reducing disease. These vaccines are licensed and produced under strict regulatory conditions ensuring their safety, efficacy and quality. The administration of these vaccines is currently using mechanical syringe with needle, an outdated method to deliver vaccines to billions of animals per year. Livestock vaccination is normally performed by hand. However, the accuracy of the operator administering the vaccine decreases significantly after a couple of hours of automatic and repetitive job, due to the large number of animals injected per hour. This way, up to 70% of dairy herds are inadequately vaccinated simply because of improper management, according to a study done by the Veterinary Teaching Hospital- Colorado State University. Particularly, the livestock industry requires a higher levels of vaccination quality to keep up with the growing global demand for higher quantities along with safe and quality products. Vaccination’s efficacy is dependent on the correct dosage being administered to every single animal, in order to create a high and uniform immune reaction. SyrinJector is the first smart syringe gun for the mass vaccination of livestock.The device is fully automated (no mechanical hand trigger), portable, and works with a software for rapid, controlled and traceable mass vaccination. SyrinJector is safetyconscious (anti-stabbing and needle disinfection mechanisms),and highly accurate, making it a must for livestock farmers. SyrinJector allows high repeatability and reduces human factor and fatigue.Our solution will gradually replace the current process of steel/plastic syringe guns and off-line paper certifications, creating a fully interconnected database system (Cloud) that smartly aggregates and manages the data coming from our digital syringe gun, right from the field.

Keywords: livestock,cattle,swine,poultry,needle,syringe,disinfection,vaccines,vaccination,safety,health,injections,traceability,data,veterinarian,dose,dosage
Profiling the emergence of phenotypic heterogeneity in breast cancer organoids (SpatialOrganoids)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Cell-to-cell heterogeneity in biological systems has been broadly studied in unicellular organisms and mammals. Furthermore, non-genetic, in addition to genetic heterogeneity has been recently proposed to support tumour growth and to induce resistance to cancer therapy. However, the molecular events on a spatial and temporal level that lead to the emergence of tumour heterogeneity are largely unknown. To address this question, I will study breast cancer, which shows the highest cancer incidence in women and is characterised by extensive intra- and inter-patient heterogeneity in cellular and molecular phenotypes. As model system, I select 3D organoid cultures, which are gaining popularity in cancer research due to their ability to reconstruct tumour-like molecular features and to recapitulate treatment response. Here, I propose experimental and computational time-course analyses of breast cancer organoids to understand molecular and spatial determinants that underlie the emergence of heterogeneity in cancer cell phenotypes. On the experimental side, I will use imaging mass cytometry and perturbation experiments to capture and validate spatio-temporal changes in cellular phenotypes, interactions and signalling networks. Statistical modelling will quantify dynamic changes in phenotypic heterogeneity over the time-course of organoid growth. Finally, I will predict the emergence of intra-organoid heterogeneity across multiple organoid lines, which allows me to derive targeted treatment strategies. In sum, the proposed work will disentangle and perturb the spatio-temporal emergence of phenotypic intra-tumour heterogeneity, which is characteristic of breast cancer tissues.

Keywords: imaging mass cytometry,breast cancer organoids,spatial data analysis
Social innovation and light electric vehicle revolution on streets and ambient (Silver Stream)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Austria,Italy,Italy,Italy,Germany,Germany,Switzerland,Slovenia,United Kingdom
Call: Electric two-wheelers and new ultra-light vehicle concepts (H2020-GV-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 4573567.5
EU funding (EUR): 3990111.25
Participants: 11
Project status: CLOSED

The SilverStream project addresses the challenges associated with sustainable and affordable personal mobility for the growing and ageing population in congested European cities. The project combines both ergonomic concepts conceived for elderly people and advanced automotive technologies that are quiet, clean, energy efficient and safe. The particular objectives of SilverStream are: i) specifications related to the needs of urban and ageing population; ii) enhanced vehicle manoeuvrability for urban context; iii) sustainable ergonomics, health monitoring and adaptive HMI for minimum-fatigue vehicle operation; iv) dual voltage 12/48 V power network for modular and scalable E/E architecture; v) hybrid energy storage system for extended operating life and increased efficiency; vi) compact in-wheel drive units for light urban mobility solutions; and vii) maximizing project impact for enhanced European competitiveness. To achieve these objectives, the SilverStream project brings together 10 committed and complementary European partners that cover the whole value chain, including SMEs, large industry, academia and research institutes. The developed technologies will be driven by a team of expert in the field of medical and cognitive science domain through a top/down approach, and will be demonstrated with a vehicle prototype running in a realistic test environment. In conclusion, SilverStream will develop and demonstrate a radically new light and affordable vehicle concept (L-category). In doing so, SilverStream provides one possible mobility solution to address the tough challenges faced by Europe in relation to the field of air quality, noise and environmental protection, traffic congestion, competiveness and jobs preservation, as outlined in the specific challenge of the work programme.

Keywords: ageing population,urban mobility,light electric vehicle,ergonomic concepts,improved drivability,energy efficiency
In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed by ATG9 (ATG9_SOLVES_IT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2024-12-31
Duration (months): 78.0
Total project cost (EUR): 2121055.0
EU funding (EUR): 2121055.0
Participants: 1
Project status: SIGNED

Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival. It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins. Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration. Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics through the cell in vesicles, and is essential for rapid initiation and expansion of the membranes which form the autophagosome. Crucially, how ATG9 functions is unknown. I will determine how ATG9 initiates the formation and expansion of the autophagosome by amino acid starvation through a molecular dissection of proteins resident in ATG9 vesicles which modulate the composition and property of the initiating membrane. I will employ high resolution light and electron microscopy to characterize the nucleation of the autophagosome, proximity-specific biotinylation and quantitative Mass Spectrometry to uncover the proteome required for the function of the ATG9, and optogenetic tools to acutely regulate signaling lipids. Lastly, with our tools and knowledge I will develop an in vitro reconstitution system to define at a molecular level how ATG9 vesicle proteins, membranes that interact with ATG9 vesicles, and other accessory ATG components nucleate and form an autophagosome. In vitro reconstitution of autophagosomes will be assayed biochemically, and by correlative light and cryo-EM and cryo-EM tomography, while functional reconstitution of autophagy will be tested by selective cargo recruitment. The development of a reconstituted system and identification proteins and lipids which are key components for autophagosome formation will provide a means to identify a new generation of targets for translational work leading to manipulation of autophagy for disease related therapies.

Keywords: autophagy,autophagosome formation,atg9,phagophore
IMproving Sustainable Development Policies and PrActices to assess, diversify and foster Cultural TOURism in European regions and areas (IMPACTOUR)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Italy,Spain,Estonia,Spain,Cyprus,Belgium,Greece,France,Netherlands,Portugal,Portugal
Call: Innovative approaches to urban and regional development through cultural tourism (H2020-SC6-TRANSFORMATIONS-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 2971250.0
EU funding (EUR): 2971250.0
Participants: 15
Project status: SIGNED

The main ambition of IMPACTOUR project is to create an innovative and easy-to-use methodology and tool to measure and assess the impact of Cultural Tourism (CT) on European economic and social development and to improve Europe’s policies and practices on CT, strengthening its role as a sustainable driving force in the growth and economic development of European regions. CT has been recognized as one of the drivers of growth, jobs and economic development, as well intercultural understanding and social development in Europe regions and urban areas.However, there is still a knowledge gap on methods to measure different types of CT impacts and to assess multilevel and cross-border strategies, policies and practices contribution to sustainable development.IMPACTOUR proposes to bring together CT-related stakeholders and researchers to achieve new approaches taking advantage of the large amounts of information that confront policy-makers. By identifying and comparing quantitative/qualitative pan-European information on CT forms and promotion, and by providing quantifiable evidence of CT strategies and their effect on European regions’ development and Europeanisation, IMPACTOUR will deliver an innovative methodology and tool (combining data analytics algorithms with artificial intelligence and machine learning strategies) providing CT stakeholders with strategic guidance so that policies and practices on CT can be improved. IMPACTOUR will encompass a sustainable ecosystem by engaging Cultural Tourism stakeholders and following a participatory approach. IMPACTOUR tools and methods will lead to reinforcing the commitment with Europe CT, increasing citizens sense of belonging, valorisation of minority cultures, strengthening of identities and Europeanisation. IMPACTOUR Methodology will be completed and tested with data coming from 15 Data Information Pilots and the IMPACTOUR tool will be validated in 5 Validation Pilots, with distinct characteristics spread around Europe.

Keywords: bottom up approach,stakeholders engagement,data analysis,sustainable cultural tourism strategies,policy recommendations
PCOS IN ADOLESCENT GIRLS AND YOUNG WOMEN: TOWARD A TREATMENT GUIDED BY PATHOPHYSIOLOGY (SPIOMET4HEALTH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Italy,Spain,Spain,Spain,Spain,Ireland,Spain,Belgium,Norway,Türkiye,Belgium,Denmark
Call: New interventions for Non-Communicable Diseases (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 6366148.5
EU funding (EUR): 6366148.5
Participants: 20
Project status: SIGNED

Polycystic Ovary Syndrome (PCOS) is the most prevalent, chronic endocrine-metabolic disorder of adolescents and young women (AYAs), affecting 5-10% of AYAs worldwide. It is the most frequent cause of anovulatory subfertility. There is no approved therapy for PCOS. Standard off-label treatment with oral contraceptives reverts neither the underlying pathophysiology nor the associated co-morbidities Pilot studies have generated new insights into the pathophysiology of PCOS, and have thus led to the development of a new approach wherein the PCOS phenotype is reverted without side effects. The novel medication is a fixed, low-dose combination of two insulin sensitisers [Pioglitazone (Pio), Metformin (Met)] and one mixed anti-androgen and anti-mineralocorticoid (Spironolactone (Spi)] within a single tablet: SPIOMET SPIOMET4HEALTH will test, in a multicentre Phase II trial, the additive effects of each SPIOMET component, on top of lifestyle measures in AYAs with PCOS. SPIOMET aims at normalising the ovulation rate and endocrine-metabolic status via the reduction of hepato-visceral fat excess, in an early phase of the disorder. This approach is expected to reduce the risk of morbidity (including subsequent anovulatory subfertility), to improve the quality of life, and to lower the economic burden on European healthcare systems. The consortium clusters the experts from key research groups working on PCOS in AYAs, across Europe. The design of SPIOMET4HEALTH foresees that the patients themselves will be engaged over the entire timespan of the project, and will also contribute to the ultimate study evaluation. The update and validation of PCOS-specific Patient Reported Outcome Measures (PROM) will provide the first large-scale evidence on the psychosocial benefits of the tested treatments. The collective evidence from SPIOMET4HEALTH, once completed with economic modelling, will lead to conclusions that inform sound decision-making about PCOS across European healthcare systems.

Keywords: androgen excess,polycystic ovary syndrome,pcos,ectopic fat,liver fat,visceral fat,central obesity,fatty liver,anovulation,ovulation,adolescence,pioglitazone,spironolactone,metformin
Development of Novel Analytical Methods to assess Nanoparticle cytotoxicity (NanoCytox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Nanoparticles , NPs, are being used to produce novel materials with unique physico-chemical properties with many applications in fields such as medicine, energy and electronics, consumer goods, among others. Some studies have revealed that the same specific properties that make NPs so unique could also be responsible for potential harmful effects on the environment and human health. Currently, the assessment of their impact is hampered by limited analytical capabilities to detect them in complex natural matrices. New sensitive and selective analytical methods must be developed and validated in order to elucidate their toxicological effects prior to increasing and promoting the NPs production. Herein, new analytical methodologies based on inductively coupled plasma mass spectrometry (ICP-MS) are proposed to evaluate the toxicity of metallic NPs in cells, one of the most powerful and attractive model systems for toxicological assays. The proposed methodology consists on the use of laser ablation (LA) coupled to ICP-MS for spatially resolved bioimaging of the distribution of NPs in single cells upon different NPs incubation experiments; furthermore, a micro-droplet generator (µDG) for sample introduction of single cells into a sector field ICP-MS will be employed to improve the NPs detection sensitivity. The expected results will give essential insights into nanoparticle/cell interactions and will have implications for the development of analytical methods based on applications of nano-particles for medical diagnostics and therapeutics.