Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy (SILICOFCM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Germany,Serbia,Serbia,Greece,Slovenia,Türkiye,Serbia,France,United States,United Kingdom,United Kingdom,United Kingdom
Call: In-silico trials for developing and assessing biomedical products (H2020-SC1-2017-CNECT-2, 2017)
Start date: 2018-06-01
End date: 2022-02-28
Duration (months): 45.0
Total project cost (EUR): 5507441.25
EU funding (EUR): 5507441.25
Participants: 19
Project status: CLOSED

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM. The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

Keywords: familial cardiomyopathy,cloud computing,data mining,image processing,protein and cell data,finite element modelling
Deflating the blow-up: controlling infinities in cosmic fluid descriptions (Cosmo-Blow-Up)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

According to the standard model of cosmology, we are witnesses of an epic battle: While dark energy leads to an accelerated expansion, matter and particularly the dark matter, opposes this trend, leading to the observed large-scale structure of the Universe. Since the pioneering discovery of dark energy that lead to a Nobel Prize in Physics, the nature of dark matter is still shrouded in mystery. What we know is that matter can be described as a fluid on macrophysical scales, and that the fluid has, at early times, no overlapping matter trajectories. Yet, matter trajectories do eventually begin to intersect ("shell-crossing"), which marks the starting point of very complex computations in the phase-space on the one side, and the birth of our cluttered Universe on the other side. Understanding the collapse and shell-crossing is quite a challenge that is usually tackled by utterly opposing means, either by (approximative) analytical models or by cosmological N-body simulations. With this Marie-Curie fellowship, I will close this gap and get full control of the instant of shell-crossing in two complementary ways. I will develop full-fledged numerical simulations of the cosmological fluid equations and develop certain matter collapse models, that, at their heart, determine the matter trajectories by exact analytical descriptions until the instance of shell-crossing, where infinities become real and the solutions "blow up". Detecting blow-ups is one of the most challenging and rewarding problems in mathematical physics; by resolving them, precious information will be gained which we will use to improve (heavily used) N-body simulations at the critical vicinity of shell-crossing. The department Lagrange (host institute) is a unique place in Europe that houses both world experts in numerical cosmology and in mathematical analysis, thereby complementing exactly my expertise (exact analytical models). This allows us to solve outstanding problems in interdisciplinary fields.

Keywords: large scale structure of the universe,shell crossing,cosmological n body simulations
Helping Businesses Thrive in Sales with a new fully automatic platform that integrates and coordinates different sales tools (THRIVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Thrive for Email GmbH (Austria) was founded in 2016, after Vincent Jong (CEO), an enthusiastic entrepreneur with more than 10 years’ experience in Sales and Business Development roles, realised that he and his sales’ team were constantly wasting too much time preparing administrative work during the sales process, and that there weren’t any solutions in the market capable of fully fulfilling this need. He then, started building a team that would begin developing the first version of the THRIVE solution: a fully automatic and intelligent platform, that is able to gather and process information exchanged during the sales process, into the company’s CRMs, without requiring any human input, as well as to detect and initiate next actions to be performed by the sales representative (rep.). With this game-changing solution we seek to help companies and its sales reps. increase their sales, solving the current problems they face in their day-to-day lives: companies are investing more in sales acceleration technologies to bridge the gap between the sales operations and business goals; and sales reps. are frustrated that deals are ‘slipping through the cracks’ as they can no longer keep track of their leads and spend too much time manually entering data into existing sales software. Having successfully launched the 1st version of the platform and gained acceptance of >365 of Salesforce CRM users, we now look to fully enhance the platforms’ capabilities and benefit a wider user base in need of a sales operations’ tool and/or boosting their sales. We consider our primary market segment to be Software as a Service (SaaS)-based SMEs, which amount 20,000 only in Europe. These can benefit from THRIVE by: Increasing Sales reps. Productivity; Reduced sales cycle’s length; Increased number of opportunities. This innovation project is expected to generate new IP and additional €33 million turnover and to increase our workforce to at least 100 people by 2025.

Keywords: sales,sale representative,customer relationship management,sales acceleration technology,communication system,e mail,phone,website,artificial intelligence,productivity,sales cycle
Ultracoherent force sensors (ULTRAFORS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Denmark
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-11-01
End date: 2020-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

As part of our ERC-funded quest for quantum-enabled micro- and nanomechanical resonators, we have developed a novel type of ‘soft-clamped’ mechanical sensors. They combine phononic engineering via periodic patterning with high tensile stress. With unprecedented quality factors and low force noise, they provide a powerful platform for an array of force sensing techniques. Applications are expected not only in quantum technologies, but also materials science and nano-medicine, by improving nano-scale force imaging modalities such as magnetic resonance force microscopy. Importantly, reduced dissipation can render costly and complex cryogenic cooling obsolete in many of these applications. In this proof-of-concept project, we will (i) develop designs optimized for force sensitivity, guided by simulation tools already developed, (ii) stabilize the nanofabrication process to improve reliability and economy of the production (iii) further pursue and expand ownership of IPR, to form the basis of commercial exploitation, and (iv) develop a business case for ultracoherent force sensors. This will lay the foundation to the launch of start-up company, or joint commercial activity with existing suppliers, to commercially provide ultracoherent force sensors.

Keywords: phononic engineering,optomechanics,force sensing,magnetic resonance force microscopy
Fact-based personalised nutrition for the young (NUTRISHIELD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Austria,Italy,Spain,Germany,Cyprus,Switzerland,Belgium,Greece,Belgium,Switzerland,Switzerland,Netherlands,United Kingdom,Luxembourg
Call: Personalized Nutrition (H2020-SFS-2018-1, 2018)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 8732209.59
EU funding (EUR): 7197096.25
Participants: 17
Project status: SIGNED

NUTRISHIELD aims at creating a personalised platform for the young. The platform will consist of novel methods & techniques, which analyse a wide range of biomarkers related to nutrition and health disorders. Based on findings, the platform then uses ICT, by expanding existing nutrition assistive mobile apps, in order to provide feedback and steering people towards a better nutrition. This takes into account the way each person responds to different nutrients and food types, by also analysing phenotype, genome expression, microbiome composition, health condition, mental & psychological condition, as well as financial capabilities for procuring food.

Keywords: personalised nutrition,diabetes,human milk,obesity,quantum cascade laser,breath analysis,urine analysis,human milk analysis
General Embedding Models for Spectroscopy (GEMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 1609500.0
EU funding (EUR): 1609500.0
Participants: 1
Project status: SIGNED

Recently, there has been a paradigmatic shift in experimental molecular spectroscopy, with new methods focusing on the study of molecules embedded within complex supramolecular/nanostructured aggregates. In the past, molecular spectroscopy has benefitted from the synergistic developments of accurate and cost-effective computational protocols for the simulation of a wide variety of spectroscopies. These methods, however, have been limited to isolated molecules or systems in solution, therefore are inadequate to describe the spectroscopy of complex nanostructured systems. The aim of GEMS is to bridge this gap, and to provide a coherent theoretical description and cost-effective computational tools for the simulation of spectra of molecules interacting with metal nano-particles, metal nanoaggregates and graphene sheets. To this end, I will develop a novel frequency-dependent multilayer Quantum Mechanical (QM)/Molecular Mechanics (MM) embedding approach, general enough to be extendable to spectroscopic signals by using the machinery of quantum chemistry and able to treat any kind of plasmonic external environment by resorting to the same theoretical framework, but introducing its specificities through an accurate modelling and parametrization of the classical portion. The model will be interfaced with widely used computational chemistry software packages, so to maximize its use by the scientific community, and especially by non-specialists. As pilot applications, GEMS will study the Surface-Enhanced Raman (SERS) spectra of systems that have found applications in the biosensor field, SERS of organic molecules in subnanometre junctions, enhanced infrared (IR) spectra of oligopeptides adsorbed on graphene, Graphene Enhanced Raman Scattering (GERS) of organic dyes, and the transmission of stereochemical response from a chiral analyte to an achiral molecule in the vicinity of a plasmon resonance of an achiral metallic nanostructure, as measured by Raman Optical Activity-ROA

Keywords: quantum chemistry,multiscale modeling
Fully-equipped electric trailer supporting the transition towards sustainable city logistics (FUTrailer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-02-01
End date: 2022-05-31
Duration (months): 28.0
Total project cost (EUR): 3061506.25
EU funding (EUR): 2143054.38
Participants: 1
Project status: CLOSED

The boom of the e-commerce together with the growing urbanisation are forcing the last-mile sector to redesign its operations. Parcel delivery companies are searching for new mobility solutions that increase the efficiency and sustainability of their activity in urban areas. Bicycles and cargo bikes have been recognised as ideal for the transport of goods in urban areas. However, current solutions in the market either have a too small carrying capacity – which makes them inefficient for the last-mile sector – or are too bulky and cannot easily overcome traffic congestion as bicycles do. At Nüwiel we have seized this opportunity and are finishing the development of FUTrailer, the world’s first electric trailer for bicycles that provides to the last-mile sector the solution to increase the payload per vehicle without scarifying its urban mobility. Thanks to our patented Intelligent Riding System technology, the e-trailer accelerates and brakes automatically mimicking the movement of the bike accurately and instantly. This ensures comfort and safety during the ride, even when carrying heavy and bulky cargo on uneven roads such as cobblestones. The e-trailer can be connected to any bike, electric bike, and even cargo bike within a few seconds. When disconnected from the bike, it can be used as an electric handcart inside buildings and pedestrian-only areas. Our current market positioning in the last-mile sector with outstanding key accounts from several segments opens up a business opportunity of €210 million. FUTrailer represents the only market-viable solution that can be smoothly integrated into current delivery fleets, enabling an efficient and emission-free movement of goods in urban areas. By 2026, 5 years after market entry, we expect to have 35,600 trailers delivering over 7 million parcels every day in cities around the world. Annually, this will replace 1 billion Km of the van trips and save more than 175,000 tonnes of CO2 emissions.

Keywords: urban mobility,last mile operations,intelligent ride system,clean transportation solution,safe,and secure transportation,multimodal trailer,flexible trailer
Integrating physiological responses into species distribution models to forecast the effects of future ocean warming and oxygen depletion on fish larvae dynamics (FUTURELARVAE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-01-03
End date: 2024-01-02
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

Assessing the effects of climate change in larval ecology is fundamental to predict the future of fish stocks and fish diversity since connectivity among fish populations depends on larval distribution patterns. To forecast these effects on larvae is challenging because each species exhibits specific responses to ocean warming and O2 depletion by improving physiological performance to adapt or shifting dispersal features to preserve climatic niche. Thus, FUTURELARVAE will incorporate physiological responses to rising temperature and O2 depletion into SDMs to mechanistically forecast the future distribution of fish larvae aiming at understanding the magnitude at which climate change will affect the suitability of present vs. future habitats for larvae that exhibit different functional guilds (pelagic vs. demersal) and life history strategies (short vs. long pelagic duration). Experimental biology will be used to produce eco-physiological data representing the larval response to present and future scenarios of climate change. These data will be integrated into SDMs using Bayesian GLMs in order to understand whether these life history strategies will succeed under future climate conditions. For this, experts in environmental computational science (ER), experimental biology (supervisor) and eco-physiology modelling (advisor) will exchange knowledge and complement each other’s know-how. The ER will gain new technical skills on analytical tools, processing of mechanistic models and apply tools to generate science-based advice for the conservation of marine resources. By the end of the MSCA-IF, the ER will have acquired transferable skills in scientific management, leadership, science dissemination/communication and stakeholder engagement and have broaden his network, boosting his career. The ER will acquire much-needed conceptual/technical skills that are in high demand during this UN decade of the Oceans and commitment to SDG14, increasing his employment opportunities.

Keywords: fish larvae ecology,climate change,eco physiology,animal behaviour,species distribution models,mechanistic ecological modelling
Perivascular cells at the crossroads of inflammation, regeneration and fibrosis (PERIF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2023-04-30
Duration (months): 90.0
Total project cost (EUR): 1976100.0
EU funding (EUR): 1976100.0
Participants: 1
Project status: CLOSED

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged/necrotic tissue. Initially beneficial, this massive inflammatory response comes with a cost, and adult injured tissues usually heal with a scar, which is an area of fibrous tissue that transiently replaces normal tissue. In chronic settings, scarring can become excessive in a process called fibrosis, to the point of preventing functional recovery of the injured organ and be life threatening. Nearly half of all deaths in industrialized world are due to diseases involving inappropriate, often chronic, inflammatory and fibrotic responses, including lung, kidney and liver diseases, scleroderma, inflammatory bowel diseases, muscular dystrophies, cardiovascular diseases, and tumors. However our current knowledge of the biological processes regulating fibrosis is partial, which has hindered therapeutic advances in the field. Recent data from our team and others drew new attention on a discrete population of mesenchymal cells that wraps around vessels, variously called mural cells, perivascular cells or pericytes, as a major source for profibrotic stromal cells generating scar tissue. Previously known for their vascular protective functions, increasing evidence suggests new and unexpected roles for these cells also in inflammation, repair/regeneration, and cancer. These new findings raise a number of challenging questions relative to their functional diversity, as well as mechanisms of activation/ regulation in disease. The identification and specific targeting of functional subsets of mesenchymal perivascular cells may have notable impact in research and medicine, paving the way for new therapeutic avenues in inflammatory/fibrotic diseases and cancer.

Keywords: biological process of fibrosis,inducible lineage tracing and genetic ablation of perivascular progenitors,targeting cancer stroma