Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
End-to-End Cognitive Network Slicing and Slice Management Framework in Virtualised Multi-Domain, Multi-Tenant 5G Networks (SLICENET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Spain,Ireland,Ireland,Italy,Israel,Ireland,Italy,Germany,Greece,Romania,Greece,France,France,United Kingdom,Portugal,Portugal
Call: 5G PPP Research and Validation of critical technologies and systems (H2020-ICT-2016-2, 2016)
Start date: 2017-06-01
End date: 2020-06-30
Duration (months): 37.0
Total project cost (EUR): 7979030.0
EU funding (EUR): 7979030.0
Participants: 18
Project status: CLOSED

5G use cases are so diverse and challenging that the 5G networks must be customisable for the broad range of individual scenarios. 5G network providers are keen to offer “networks as a service” where logical network slices are created and allocated to use cases flexibly and efficiently in a multi-operator environment. SliceNet will create and demonstrate the tools and mechanisms to achieve this ambition. Specifically, SliceNet will design, prototype and demonstrate an innovative, verticals-oriented, QoE-driven 5G network slicing framework. It will use cognitive network management, control and orchestration techniques for the provision and operation of end-to-end slicing across multi-operator domains in 5G networks. SliceNet will systematically tackle a range of the involved outstanding issues and thus directly addresses the key challenges in Strand 3 “Software Network” in this call ICT-07-2017. The integrated SliceNet framework will be demonstrated in three representative vertical use cases: Smart Grid, eHealth and Smart City, to highlight the achievements, innovations, and impacts. SliceNet support the unique perspectives and requirements on 5G networks of different players: For 5G verticals businesses, SliceNet offers an innovative one-stop shop solution to meet diverging and demanding service requirements. SliceNet enables the verticals to plug and play their use cases with bespoke control to employ 5G slices in a scalable, cost-efficient way via novel mySlice and Scalable Slicing as a Service functions and a one-stop API. For 5G service providers and users, SliceNet provides unprecedented guaranteed service quality by agile cognitive QoE-optimisation of service creation and delivery. For 5G network operators, SliceNet presents an integrated FCAPS (Fault, Configuration, Accounting, Performance, Security) framework for truly end-to-end management, control and orchestration of slices by secured, interoperable, and reliable operations across multi-operator domains.

Keywords: network management,slicing,slice management
Underground power cables remote monitoring by a smart control system based on a novel optical sensor platform (CableSENS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

More and more Electricity System Operators (ESOs) are required to bury larger number of sections of the power grid mainly because security, visual and environmental impact concerns. However, such underground sections have a negative impact on the overall power supply efficiency, quality and security, resulting in severe economic losses and reduction in reliability of the grid. Besides, underground sections are more difficult and expensive to install, operate and maintain. In addition to the economic impact on the ESOs, underground faults also have a negative impact on society directly depending on the blackout time (time between breakdown and restoring) of the line. The development of the future Smart Power Grids requires an improvement in efficiency and security, through the implementation of new technological solutions that in addition will allow reducing operation and maintenance (O&M) costs incurred by the ESOs. Lumiker, a European R&D SME developing disruptive solutions for the power industry, has detected a market opportunity in such sector: ESOs lack smart solutions providing remote and real time information regarding: i) the condition of the underground sections (damage); ii) discrimination of faults (overhead or underground) and iii) rapid localization of underground faults. Such solutions will allow to reduce both the outage time of the power grid and associated costs, especially for the underground sections. Improved control of the underground sections of the power grid could help ESOs to reduce up to 76% of O&M associated costs in such underground sections. Lumiker will take advantage of this business and market opportunity by introducing into the market the CableSENS system, a novel application based on Lumiker’s patented optical sensor platform adapted for real time and remote condition monitoring of power cables, a unique combination of features into a stand-alone system with direct impact not only in the power grid industry but also in the society.

Keywords: optical current sensor,monitoring system,smart grids,photonics,real time,remote,passive,energy efficiency,underground power grid,cable condition monitoring,operation,maintenance
Towards a new generation of user-centred Energy Performance Assessment and Certification; facilitated and empowered by the EPB Center (U-CERT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Italy,Estonia,Spain,Belgium,Romania,Sweden,Bulgaria,Slovenia,Hungary,France,Netherlands,Netherlands,Netherlands,Denmark
Call: Next-generation of Energy Performance Assessment and Certification (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 1999423.75
EU funding (EUR): 1999421.0
Participants: 17
Project status: SIGNED

The main aim of U-CERT is to introduce a next generation of user centred certification schemes to value buildings in a holistic and cost-effective manner. This aims to: - facilitate convergence of quality and reliability, using the under the M480 mandate developed national annexes standards, enabling a technology neutral approach that is transparently presented; - encourage the development and application of holistic user-centered innovative solutions, including the smart readiness of buildings; - encourage and support end-users in decision making (e.g. on deep renovation); U-CERT has a focus on strengthening actual implementation of the EPBD by providing insights from an user perspective and creating a leveled playing field for sharing implementation experience, (Mandate M/480 and product related) to all involved stakeholders, facilitated by the EPB-center. U-CERT has the following five measurable objectives: 1: Facilitating the implementation of the new generation of Certification Schemes with a wide based support 2: Making the new certification schemes more practical, reliable and ‘desirable’ by a holistic and user centered approach 3: Making the new certification schemes easy accessible for a wide range of users and stakeholders by the services of the EPB center This objective has a twofold approach: 1) by accelerating the implementation by the development of a set digital supporting tools and 2) by incubating new certification concepts and business models, empowered by the U-CERT results. The EPB center has a central role in achieving this objective by offering services to all relevant stakeholders in order to promote and foster a harmonized and comparable implementation of the EPBD. 4: Providing evidence of the usefulness and meaningfulness of developed means by testing the U-CERT approach in selected cases by the EPB center. 5: To foster a EU-wide uptake by motivating and activating EU interest groups and certifying bodies (not involved in U-CERT)

Keywords: energy performance assessment,certification schemes
The first Behavior Recognition Open Platform (Gestoos)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: TERMINATED

Despite the increasing presence of automated systems and devices in every aspect of our lives, multiple strategic sectors in our society are still dependent on human intervention, such as transport, health and security, among others. However, this dependency causes that human error can lead to insecurity, danger and physical injury, such as in 93% of road fatalities. Exipple Studio S.L. (from now on, Exipple) is revolutionising the Computer Vision sector by providing a new standard for human-machine interaction specially designed for reducing the impact of human error and save lives. The company has designed Gestoos: an open platform for behaviour recognition that enables any device or surface to understand the actions of the user. Currently in a prototype state, specialized in the understanding of short-term actions and enabling gesture control, the goal of this project is to develop a full version of the platform that is able to autonomously identify different semantic context based on natural language inputs in order to differentiate amongst similar behaviours in different contexts. Gestoos has been architected as an enabling technology: the platform is an open, hardware-agnostic and auto-learning solution that will enable any device, surface or solution to identify the user behaviour and react accordingly. As a result, Exipple aims at granting accessibility to behaviour recognition to any company, research centre or institution willing to include a smart AI in their product or service. For this feasibility study, Exipple aims at devising an extensive expansion and R&D plan in order to introduce the disruptive potential of Gestoos in key economic sectors: eHealth, Automotive and Consumer Electronics Home Automation. Thanks to a phased and multivertical commercial approach, the company expects to establish a new standard in human-machine interaction, expanding to Europe, US and Asia by 2021, generating over 47 million in revenue and employing over 80 jobs.

Keywords: gestural control,behavior recognition,multimarket impact,human machine interaction,feasibility study,iinternational business plan,technical study,prototype demonstration
A revolutionary cybersecurity SaaS helping small-medium business (SMEs) to protect their networks like large corporates do! (ODIX 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-16
End date: 2021-06-15
Duration (months): 24.0
Total project cost (EUR): 2783875.0
EU funding (EUR): 1948712.5
Participants: 1
Project status: CLOSED

Incoming files present one of the most serious threats to every corporate network. Cyber attackers have the knowledge and resources to implement highly sophisticated attacks using various methods such as encrypted and distributed malware attacks, zero-day attacks and more. These are delivered via files which are introduced into the target network by various channels, including email, removable media, and web download. Malware attacks can create serious damage to the organization but current available defensive measures fail to provide any protection against such attack. The SMEs, accounting for over 95% of firms, require and demand special response to the vulnerability they have against cyberattacks. Yet, none of the existing solutions in the market, even less those based on military technology, is giving answer to them. ODIX 2.0 is the next generation of malware protection that is revolutionizing the way organizations protect their company from known and unknown threats. While other solutions focus on analysing user’s behaviour and statistical data to try and DETECT the undetectable, our game changing approach is to proactively PROTECT, sanitizing every file (keeping their full functionality) with our unique anti malware technology. After carrying out a feasibility study considering technical, practical, and financial aspects, we have successfully confirmed ODIX’s viability as a significant business opportunity. Through SMEi-Phase 2 we plan to 1) Enrich our solution with innovative features and functionalities, evolving ODIX-2.0 from TRL6 To TRL9; 2) pave the way towards its successful international market exploitation; 3) develop an operational strategy to grow our company based on the SME market, the power to easily and cost-effectively protect their files. Thus, in the next two years, ODI aims to accelerate its global rollout by expanding engagements with existing clients, and gaining new customers in key areas in Europe, US and Asia.

Keywords: malware,cyber attacks,prevention,cyber security,innovation,anti malware,information,security
Analysis of “difficult” proteins by microfluidic-based hydrogen/deuterium exchange (HDXchip)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999752.0
EU funding (EUR): 1999752.0
Participants: 1
Project status: SIGNED

Many proteins important in biology or disease are not amenable to traditional methods for structural analysis as they cannot be isolated in sufficient amounts nor studied directly in their native environment. Alternative techniques are needed to understand the conformation and interactions of such difficult proteins and further support the on-going shift to protein-based ‘biopharmaceuticals’ in the pharmaceutical industry. One promising technique to meet this challenge is the use of mass spectrometry to measure the hydrogen/deuterium exchange of proteins (HDX-MS). However, HDX-MS suffers from significant limitations to realize its full potential and applicability. HDXchip aims to develop innovative microchips to revolutionize the HDX-MS method and enable analysis of difficult protein systems of unprecedented complexity. HDXchip will create “HDX-MS 2.0” technology that integrates on-chip sample treatment and separation to overcome major limitations of the conventional method, including virtually eliminating unwanted deuterium loss (back-exchange). The key to fabrication of HDXchips lie in the fact that all elements will be made of thiol-ene polymers. These polymers are not only used to make the chip itself in a cheap and simple manner, but also to fabricate high surface area functionalities for fast sample treatment (incl. enzymatic reactions) and separation at unprecedented efficiency. HDXchip will enable step-change improvements in popular HDX-MS applications, like analysis of the conformation and interactions of purified proteins and also open up for exciting and hitherto unfeasible applications such as analysis of proteins inside whole cells and proteins in their native lipid membranes. Hence, HDXchip could enable breakthrough insights into the conformation of difficult protein systems both in isolation and in their native environment, and dramatically improve our understanding of the function of such proteins and their potential to be targeted by drugs.

Keywords: hydrogen,deuterium exchange mass spectrometry,protein dynamics and interactions,microfluidics
SOmatic MUtagenesis in Kidney Tubule is enhanced by specific metabolic pathways (SoMuKT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-09-26
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

An important factor favoring cancer initiation is the lifelong accumulation of somatic mutations in the genome. In agreement, somatic mutations in a specific set of driver genes has been shown to drive the transition from a healthy cell to a tumorigenic clone in the kidney. The vast majority of kidney tumors originate from a specific segment of the kidney nephron, named proximal tubule (PT). However, the rate of somatic mutation accumulation before tumorigenic transformation in the kidney PT and the causes underlying this phenomenon are unexplored. Somatic mutation data can be used as a footprint to track the mutational processes that occurred in a specific cell during an individual´s lifetime. I established a protocol for reliable detection of somatic mutations in non-cancer human cells. I obtained whole genome data from clonally expanded single cells from skeletal muscle, kidney, fat and skin of healthy donors. My preliminary data point to an increased rate of somatic mutation accumulation during adult life in kidney PT compared to other kidney and non-kidney cells. PT cells showed a unique mutation pattern and distribution that enhances the chances of acquiring a driver mutation and tumorigenic traits. The very homogeneous pattern of somatic mutations in PT cells leads me to the hypothesis that the kidney PT is exposed to genotoxic compounds that are endogenously produced during physiological cellular activities. In particular, my data point to specific metabolic pathways, including 1) ammonia production, 2) aminoacid metabolism /reabsorption from the urine and 3) response to hypoxia. I will use cellular models to perturb the metabolic homeostasis of the kidney PT and test the effect on somatic mutagenesis and underlining mechanisms. My project will shed light on a mostly unexplored topic: how cellular metabolism can damage the genome over time and may have important implications for tumor prevention.

Keywords: somatic mutations,kidney cancer,kidney proximal tubule,aging,endogenous mutagens
Targeting Rab27A with covalent inhibitors for the treatment of metastatic breast cancer (RabTarget4Metastasis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2022-10-29
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Invasion and metastases remain to date the major causes of cancer mortality around the world. Rab27A is a small GTPase that regulates vesicles trafficking and is involved in many physiological processes, e.g. melanosome transport. Being a small GTPase, Rab27A acts as a molecular switch that cycles between an inactive state (GDP bound) and an active state (GTP bound), in which this protein is able to bind to specific effectors to trigger signalling cascades in cells. Current studies suggest a role for Rab27A in exosome-mediated pre-metastatic niche promotion. Hence, interfering with Rab27A PPIs could be effective in reducing and preventing the occurrence of metastasis in cancer. Small GTPases are renowned as challenging targets and have been long considered undruggable, but the unique presence of two non-conserved cysteines in Rab27A offers a perfect starting point for the development of selective covalent inhibitors. These residues are located in the proximity of a major interaction site with a known effector of Rab27A, Slp2, therefore encouraging for targeting PPIs. A screen of covalent fragments based on the recently developed quantitative Irreversible Tethering (qIT) assay has led to the discovery of novel hits with enhanced reactivity for Rab27A against glutathione. The current project aims to (i) obtain potent Rab27A covalent inhibitors by growing hit fragments, and (ii) demonstrate selective Rab27A target engagement in cells, and efficient disruption of the PPIs of Rab27A with its main effectors. Collaboration with the CRUK Beatson Institute will provide direct access to in vivo models to validate the contribution of Rab27A to metastatic development in cancer by use of such chemical probes, whilst state-of-the-art covalent fragment know-how will be accessed for compound optimisation at the Francis Crick Institute/GSK LinkLab, enabling prompt evaluation of the therapeutic potential of optimised lead compounds that will derive from my work.

Keywords: small gtpases,covalent inhibitors,high throughput synthesis,protein protein interaction targeting,cancer,metastasis
A highly efficient propulsion system for micro- and nano-satellites able to double the mission lifetime and to position satellites with unprecedented accuracy (IFM nano thruster)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Austria
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Several players are investing in Constellations of Satellites to provide customers services as global imaging in near real time, telephone & internet coverage, monitoring of ships, airplanes, fires etc. The global market of this new space race, worth 2.2 B$ in 2016, is expected to increase to 5.3 B$ in 2021. Several players are trying to disrupt market by lowering manufacturing costs, but the most difficult component to acquire remains the propulsion system: these satellites, in fact, work without a propulsion system, resulting in high replacement rates (once per year), limited orbit manoeuvres, difficulties in flight formation, passive deorbiting not sufficient to put satellites into graveyard orbits at their end of life. AMR propulsion aims to solve these problem with a unique, modular product: the IFM nano thruster, a compact (1dm3, <1kg), modular propulsion system with the highest propellant efficiency, capable of control satellites position with an unprecedented accuracy, perfectly suitable for single CubeSats as well as for big constellations of satellites (>100). The core, proprietary technology is based on a widely tested (10,000+ h) thruster developed for large satellite control in future ESA missions, specifically re-engineered to fit the space and mass constraints of small satellites. The thruster is based on a porous tungsten crown emitter employing 28 needles, instead of a single one, for field emission. Each porous needle combines he advantages of both the capillary needle and the solid needle, resulting in high resistance to contamination and small size. The manufacturing process is extremely difficult: it took ten years to be perfected and Propulsion is the unique proprietary of this huge know-how. During Phase 1 project, Propulsion will assess the scale-up industrialization plan and will evaluate a sound go-to-market strategy to ensure successful commercialization of IFM nano thruster.

Keywords: propulsion,cubesat,satellites,thruster,mission,constellation of satellites,propulsion system,rocket,delta v,specific impulse,indium,propellant,ion source,deorbiting time,spacecraft,nasa