Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic markers assisted selection for improvement of swine breeding productivity. (SWINE-GEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Laboratorios Dr. Larrasa. S.L is a privately owned biotechnology company founded in 2002. Led by a team of experts in veterinary, genetics and molecular biology (most of them PhDs), the company was born as a veterinary diagnostics laboratory to serve the needs of the farming industry. The ultimate objective we seek in the SWINE-GEN project is to implement in farms a unique and proprietary technology for improving swine breeding productivity. The core component of our technology is a genetic biochip specifically designed for the analysis in blood samples of those genetic markers that affect swine prolificacy (litter size at birth). Through our technology it will be possible to select the most fertile animals to mate, upon the most accurate information of genetic markers linked to reproductive traits in pigs. In this way, it will be possible to increase the number of piglets per litter in swine breeding (from an average of 9-10 piglets/litter to 11-12 piglets/litter). Moreover, as the selection will be based on genetic markers, it will be possible to stimulate a higher % of inheritance of selected genes from parents to their offspring. Therefore, the solution we propose will allow the improvement of swine breeding productivity generation after generation, having a huge impact on the productivity of the pork industry.

Keywords: genetics,swine and pork industry,breeding productivity
Support to the Europe PMC initiative – Co-funding grant for the 2016-2021 period (ERC-EuropePMC-2015)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: ERC-14 (H2020-Adhoc-2014-20, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 6071428.57
EU funding (EUR): 850000.0
Participants: 1
Project status: CLOSED

The proposed coordination and support action will provide continued support to the European Research Council (ERC) in the implementation of its Open Access strategy for projects funded in the Life Sciences domain. It follows on from the projects “Support towards the Europe PMC initiative – Contribution for 2014-2016” (ERC-EuropePMC-1-2014) and “Support towards the Europe PMC initiative – Contribution for 2013” (ERC-EuropePMC-SUP-2013) which allowed the ERC to offer the benefits of Europe PubMed Central (Europe PMC http://europepmc.org/) to its funded researchers for the first time in 2013. The proposed project concerns the giving of a grant to EMBL-EBI for the purpose of ensuring the further development and maintenance of Europe PMC, beyond the work done as part of ERC-EuropePMC-SUP-2013 and ERC-EuropePMC-1-2014, for the period 1st April 2016 – 31st March 2021 (60 months). Support towards this project is requested from the ERC on a co-funding basis.

Keywords: open access,europe pmc,repository
Advancing Synthethic Supramolecular chemical biology (ASSEMBLY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-12-23
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Many supramolecular systems have been inspired by nature, but the number of supramolecular systems that are truly functional in water at the low concentrations required for biomolecular studies are very limited. Cucurbiturils are one of a few select supramolecular systems that show great promise for the modulation of protein assemblies in biologically relevant media, but they require better means to control homo- and heterodimerization. In order to effect strong and selective heterodimerization I will design and synthesize a wide range of complementary guest pairs, using chemical and electronic concepts such as π-π stacking and electronic donor−acceptor pairs. After testing these on the cucurbituril host-guest system, they will be assessed on heterodimeric protein assemblies such as split luciferase. As many biological processes require multimeric protein assemblies, I will develop novel supramolecular constructs to gain control over the formation of such assemblies. By constructing protein-coupled cucurbiturils and developing novel double cucurbituril systems, trimeric and tetrameric protein assemblies will be assessable. Development of these advanced supramolecular tools is crucial in order to access synthetic signaling platforms with potential for molecular diagnostics.

Keywords: chemical biology,cucurbituril host guest chemistry,protein assembly
Advancing the Science for Aviation and ClimAte (ACACIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Switzerland,Norway,France,Netherlands,United Kingdom,United Kingdom
Call: Aviation operations impact on climate change (InCo flagship) (H2020-MG-2019-SingleStage-INEA, 2019)
Start date: 2020-01-01
End date: 2024-02-29
Duration (months): 50.0
Total project cost (EUR): 2999500.0
EU funding (EUR): 2999500.0
Participants: 11
Project status: SIGNED

Non-CO2 emissions of aviation may impact climate as much as aviation's carbon dioxide (CO2) emissions do. However, the impact the non-CO2 effects (e.g., ozone and methane from NOx emis-sions, contrails, indirect aerosol effects) is associated with much larger uncertainties, some of these effects might result in a relatively large cooling. ACACIA has four aims for scientifically based and internationally harmonised policies and regulations for a more climate-friendly aviation system. (1) We will improve scientific understanding of those impacts that have the largest uncertainty, in particular, the indirect effect of aviation soot and aerosol on clouds. (2) We will identify needs for international measurement campaigns to constrain our numerical models and theories with data and we will formulate several design options for such campaigns. (3) Putting all aviation effects on a common scale will allow providing an updated climate impact assessment. Uncertainties will be treated in a transparent way, such that trade-offs between different mitigation strategies can be evaluated explicitly. This helps our final aim (4) to provide the knowledge basis and strategic guidance for future implementation of mitigation options, giving robust recommendations for no-regret strategies for achieving reduced climate impact of aviation. To this end, ACACIA brings together research across scales (from plume to global scale), from the laboratory experiments to global models, and it proceeds from fundamental physics and chemistry to the provision of recommendations for policy, regulatory bodies, and other stakeholders in the aviation business. Additionally, ACACIA will cooperate with international partners, both research institutions and organisations.

Keywords: green flight,non co2 effects,indirect aerosol effects,contrails,metrics,measurement campaign
PREVENTING, COUNTERING, AND INVESTIGATING TERRORIST ATTACKS THROUGH PROGNOSTIC, DETECTION, AND FORENSIC MECHANISMS FOR EXPLOSIVE PRECURSORS (ODYSSEUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Germany,Spain,Israel,Greece,Romania,Greece,Greece,Bulgaria,France,Czechia,United Kingdom,Luxembourg,United Kingdom
Call: Chemicals: intelligence, detection, forensics (H2020-SU-SEC-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 5604543.75
EU funding (EUR): 4996350.0
Participants: 18
Project status: SIGNED

ODYSSEUS aims to increase the knowledge on explosive precursors and homemade explosives (HMEs), including precursors not previously studied, and develop effective and efficient prognostic, detection, and forensic tools to improve the capabilities of LEAs towards the prevention, countering, and investigation of terrorist incidents involving HMEs. ODYSSEUS will build upon relevant previous projects mainly HOMER, through the involvement ofHOMER’s core partners in this consortium, and will thus continue the work already done in HOMER on some precursors and further extend it to not previously studied precursors. To discover potentially hitherto unknown information, online HMEs recipes will be collected and their content will be analysed so as to extract knowledge about (possibly unknown) precursors and HMEs. Selected precursors will be then characterisedand analysed for determining their explosive properties, feasibility, and potential for becoming a threat.This knowledge will be leveraged for developing tools for(i) chemical supply chain monitoring for irregularity detection to enable prediction and localisation of potential threats; (ii) advanced sensors for detecting in (near) real-time explosive precursors through air emissions and sewerage networks; (iii) robotised tools for improved mobile detection and in-situ forensic support; and (iv) automated threat detection, localisation, and assessment; these tools will be integrated into a configurable platform that will assist LEAs’ operations in diverse scenarios. ODYSSEUS will be validated in lab and field tests and demonstrations in three operational use cases. Extensive training of LEAs' personnel, hands-on experience, joint exercises, and training material will boost the uptake of ODYSSEUS tools and technologies. With a Consortium of 4 LEAs, 9 Research/Academic partners, and 5 industry partners, ODYSSEUS delivers a strong representation of the challenges, requirements and tools to meet its objectives.

Keywords: leas,hmes recipes collection,explosives precursors knowledge,supply chain analysis,sensor development,threat detection,decision support,robotised tools
Role of epigenetic mechanisms in random X chromosome inactivation in vivo. (CHROMATIX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Developmental progression is linked to accumulation of epigenetic memory mainly in the form of chemical modifications of the chromatin. However, the dynamics of this process as well as its functional relevance remains unclear. One of the most striking examples of transcriptional regulation by epigenetic processes is random X chromosome inactivation (XCI) in female mammalian embryos, which evolved to compensate between XX and XY individuals. This process is strictly dependent on coating of one X chromosome by a long non-coding RNA, Xist. This process is also associated with rapid and dramatic remodelling of the chromatin resulting in the loss of active epigenetic marks and reciprocal accumulation of repressive ones. The functional relevance and exact specio-temporal dynamics of this process remains elusive. Here I propose to address these questions by using an integrated approach linking in vivo with in vitro experiments as well as population-based and single-cell studies. I will use a proprietary single-cell ChIPseq method and standard ChIPseq assay to assess the dynamics of X chromosome epigenetic inactivation. Further transcriptomic experiments and chromatin accessibility profiling will add additional depth to a dataset accounting to a roadmap for XCI. I aim at identifying the initial stages of epigenetic programming leading to transcriptional repression as well as genomic loci involved in nucleating these changes. I will finally address the functional relevance of X chromosome epigenetic programming by using gene knockout models and genome-wide single cell transcriptomics approach. Such work will have wide-raging implications beyond the field of XCI. By achieving unprecedented level of information on the heterogeneity and dynamics of epigenetic processes this project will allow further studies of similar processes occurring in development, aging or carcinogenesis.

Keywords: x chromosome inactivation,epigenetics,stem cell,development,transcription,histone,pluripotency,chipseq,single cell
MIXed plastics biodegradation and UPcycling using microbial communities (MIX-UP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Germany,Germany,Spain,Germany,China,Finland,France,France
Call: Microorganism communities for plastics bio-degradation (RIA) (H2020-NMBP-BIO-CN-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 7365335.0
EU funding (EUR): 5465335.0
Participants: 16
Project status: SIGNED

The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are required to change the traditional value chain of plastics to a sustainable one, based on biodegradable plastics. In MIX-UP, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET, and PS), along with upcoming biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations, thereby generating a workflow that increases the recycling quota and adds value to poorly recycled plastics waste streams. Successive controlled enzymatic and microbial degradation of mechanically pre-treated plastics waste will be combined with subsequent microbial conversion to value-added chemicals and polymers by mixed cultures. We will optimize known plastics-degrading enzymes for high specific binding capacities, stability, and catalytic efficacy towards a broad spectrum of plastics polymers under high salt and temperature conditions by integrated protein engineering, and also isolate novel enzymes with activities on recalcitrant polymers. MIX-UP will also optimize the production of enzymes and formulate enzyme cocktails tailored to specific waste streams. Implementation of these enzymes, both in vitro and in vivo, enables stable self-sustaining microbiomes to convert the released plastic monomers selectively into at least six value-added products, key building blocks, and biomass. Any remaining material recalcitrant to enzymatic activity will be recirculated into the process after a physico-chemical treatment. The Chinese-European MIX-UP is a multidisciplinary and industry-driven consortium that addresses the market need for novel sustainable routes to valorise plastics waste streams. MIX-UP realises a circular (bio)-economy and could be a viable alternative for mechanical and chemical recycling.

Keywords: polyhydroxyalkanoate,synthetic biology,plastic recycling,plastic crisis,metabolic engineering,microbial consortia,mixed plastics valorisation,biobased plastic,depolymerisation
Air Induced friction Reducing ship COATing (AIRCOAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Cyprus,Malta,Belgium,Belgium,Finland,Netherlands
Call: Innovations for energy efficiency and emission control in waterborne transport (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 5901541.25
EU funding (EUR): 5299097.38
Participants: 11
Project status: CLOSED

The overall goal of AIRCOAT is to make European waterborne transport more energy efficient and less polluting by developing a disruptive hull coating that reduces the frictional resistance of ships. The AIRCOAT project will enhance a passive air lubrication technology that utilises the biomimetic Salvinia effect. This effect enables trapping air through combination of a hydrophobic micro-structured surface with hydrophilic pins. The project will technologically implement this effect on a self-adhesive foil system. Applying a ship with such an AIRCOAT foil will produce a thin permanent air layer, which reduces the overall frictional resistance while acting as a physical barrier between water and hull surface. Besides substantially reducing main engine fuel oil consumption and hence exhaust gas emission, the air barrier further inhibits the attachment of fouling, the release of biocide substances (of underlying coatings) to the water and mitigates the radiation of ship noise. As a refit technology, it is immediately applicable to the whole fleet, is independent of the fuel type and can be combined with other efficiency improving technologies. Consequently, the technology creates both an economical and an environmental benefit. The interdisciplinary AIRCOAT consortium will develop small-scale prototypes to optimise the surface characteristics of this new technology supported by experimental and numerical methods. AIRCOAT will further produce large-scale pilots to demonstrate the efficiency and industrial feasibility in operational environments (laboratory, research ships and container ship). Finally, the project will perform a full-scale validation process to boost the technology towards market readiness. The AIRCOAT project will demonstrate the high potential of this game-changing technology to revolutionise the maritime coating sector and to become a ground-breaking future energy efficiency and emission reduction technology.

Keywords: air lubrication,friction reduction,hull coating,energy efficient,environmentally friendly,salvinia effect,biomimetic technology
Hybrid automated machine integrating concurrent manufacturing processes, increasing the production volume of functional on-demand using high multi-material deposition rates (KRAKEN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Switzerland,Romania,Switzerland,Belgium,Greece,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Novel hybrid approaches for additive and subtractive manufacturing machines (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 5947836.25
EU funding (EUR): 4711586.25
Participants: 17
Project status: CLOSED

KRAKEN will develop a disruptive hybrid manufacturing concept to equip SME and large industries with affordable All-in-one machine for the customised design, production/reparation and quality control of functional parts (made in aluminium, thermoset or both materials combined from 0,1m till 20m) through subtractive and novel additive technologies in vast working areas without floor space requirements. In KRAKEN project, new additive technologies targeting large areas using aluminium grades as well as thermoset materials will be validated at lab scale (TRL 4) and in relevant environments (TRL 5) and finally integrated and combined (¡Error! No se encuentra el origen de la referencia.) for the demonstration in industrial relevant environments (TRL 6). KRAKEN will collaborate to the consolidation of the Hybrid Manufacturing value chain by means of a consortium specially selected for linking research results to technological necessities in the fields of software, monitoring, automation, materials, standardization and end-users. KRAKEN machine will be devoted to the production and reparation of functional parts of any size with dimensional tolerances under 0.3 millimetres and surface roughness under Ra 0,1 µm aiming to achieve 40% reduction in time and 30 % in cost and 25% increase in productivity. KRAKEN machine will be based on hybrid approach merging MEGAROB subtractive machine (working area 20x6x3 metres) together with high efficient metallic and novel non-metallic AM. After the end of the project, KRAKEN machine will be an affordable solution (1.5M€ estimated selling price, lower than current equipment and strategies for the production of final parts) for the customised production of large size functional parts; decreasing time (40%) and cost (30%), increasing productivity (at least 25%) and with a 90 % reduction of floor space required because it uses an ceiling installation broadly extended into the whole industry

Keywords: hybrid manufacturing,multi material,real time monitoring