Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design against DISTortion of metallic aerospace parts based on combination of numeRical modelling ACTivities and topology optimisatION (DISTRACTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Netherlands
Call: Design Against Distortion: Part distortion prediction, design for minimized distortion, metallic aerospace parts (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-04
End date: 2019-01-03
Duration (months): 36.0
Total project cost (EUR): 449420.0
EU funding (EUR): 449420.0
Participants: 2
Project status: CLOSED

Thanks to the implementation of advanced CAD and topology optimisation, lighter and more efficient component designs can be conceived nowadays. However, current design tools and methodologies do not account for part distortions in manufacturing. Distortions are critical during prototyping and ramp up stages and they increase developing costs, times and generate wastes and scraps. Design against Distortion topic is focused on the development of numerical modelling strategies which can anticipate distortions even from the design stage. In this context, DISTRACTION project copes with the development and application of rapid distortion prediction numerical methodologies applicable to machining and additive layer manufacturing (ALM) of metallic parts and the development of concurrent topology optimisation codes capable of accounting for part distortion. Integration will be based on efficient adjoint sensitivities for simplified distortion prediction models. This will enable for first time to have optimised designs which are “ready-for-production” and robust against distortions. Developments will be applied to relevant use cases and will be based both on open source and commercial software. The following specific objectives are targeted: •A 30% weight reduction of fuselage component’s weight •Reduction of manufacturing costs of new fuselage parts by 20% •Reduction of time-to-market of new fuselage parts by 25% •Reduction of computational times by 30% for predicting distortions •Reducing scrap ratio of fuselage parts during prototyping and ramp up phases by 50% Consortium (IK4-LORTEK & TU-DELFT) of DISTRACTION proposal will have as reference internal know-how related to all previous developments in simplified Finite Element methodologies. The working group will be composed by skilled researchers and technicians with extensive knowledge and expertise in numerical modelling, residual stresses and distortion engineering, additive manufacturing and topology optimisation.

Keywords: distortion prediction modelling,simplified models,sensitivity analysis,additive layer manufacturing,machining,topology optimisation,ti 6al 4v,aa7050 t7451
Quantum Field Theory with Gaussian Multiplicative Chaos (QuantGMC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-09
End date: 2021-05-08
Duration (months): 14.0
Total project cost (EUR): 114746.24
EU funding (EUR): 114746.24
Participants: 1
Project status: CLOSED

The proposed goal for our research program is to attack some mathematical problems arising in constructive two dimensional Quantum Field Theory (QFT) and two dimensional Quantum Gravity (QG) using probabilistic methods. The physical theory of Quantum Gravity has the aim of providing a unified framework which encompasses the two descriptions of nature provided by quantum mechanics and general relativity. The two dimensional version of the theory is more tractable than the one corresponding to the four dimensional space-time and thus is used as a testing workbench to understand higher dimensional physics. In order to reinforce the rigourous mathematical understanding of this theory, we wish to explore two particular aspects of QFT which are based on a probabilistic construction called Gaussian Multiplicative chaos. The objectives of QuantGMC are: A- To obtain an explicit construction of canonical random surfaces equipped with a structure of Kähler manifold. In technical terms this corresponds to the construction of a path integral corresponding to the coupling of Liouville functional and the Mabuchi K-energy on 2D manifold of arbitrary genus. B- To enhance the current understanding of the Quantum Sine-Gordon model, which can be interpreted as a random version of the Sine-Gordon equation. This model is conjectured to undergo an infinite sequence of collapse transitions when the inverse temperature increases. However up to now, rigorous renormalization theory of the model can only allow to witness the three first of these transitions. We plan to use Gaussian Multiplicative Chaos to provide a more efficient renormalization scheme which would allow to account for all the transitions.

Keywords: gaussian multiplicative chaos,quantum field theory,quantum gravity,sine gordon model,riemannian geometry
Measuring Interstellar Reactions of Aromatics by Gas-phase Experiments (MIRAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The recent discovery of benzonitrile in a nearby cold molecular cloud (Taurus) marks the first detection of an aromatic species in the interstellar medium by radio astronomy. Benzonitrile provides a key link to benzene, which may be a low-temperature precursor to more complex polycyclic aromatic hydrocarbons (PAHs). Understanding the origin of PAHs will help answer fundamental questions about their role in forming interstellar dust as well as potentially prebiotic molecules—material that may be incorporated into new planetary systems. Computational models are used to pinpoint individual chemical pathways by inputting kinetic rates of various formation and destruction reactions and aiming to reproduce the molecular abundances determined by radio astronomy. Many of these rates have not been measured in the laboratory, especially at low temperature. The MIRAGE project aims to measure reaction kinetics of functionalized benzenes at temperatures relevant to the cold interstellar medium and use these measurements to understand radio observations of aromatics in Taurus molecular cloud. To do this, we will use a new technique in development at the Université de Rennes 1 that combines chirped-pulse (sub)mm-wave (CPMW) rotational spectroscopy with uniform supersonic flows generated by the CRESU technique. This apparatus (one of only a few in development worldwide) will be used to measure kinetics for reactions of benzene. These data are critical to accurately explain the observed abundance of benzonitrile, as well as predicting the abundances of other aromatic species currently targeted for detection.

Keywords: gas phase kinetics,spectroscopy,radio astronomy,cold molecules
NHM Researchers Night (NHM Night 7)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-07-01
End date: 2020-02-29
Duration (months): 20.0
Total project cost (EUR): 370013.75
EU funding (EUR): 181194.0
Participants: 1
Project status: CLOSED

Building on our experience in delivering successful European Researchers Nights, the NHM led partnership aims to deliver 12 inspirational events at 6 locations involving 6 partners (3 new to ERN). The collaboration will deliver an extensive impact-rich awareness campaign, which over two years will make over 10 million aware of ERN and its objectives. NHM and 5 subcontractors’ objectives beautifully align with ERN’s: • Increase awareness of the importance of research and innovation to society and our lives now and in the future • Directly engage public audiences with researchers, specifically targeting 18 – 35 yrs • Inspire school students to aspire to a career in science through engagement with researchers demonstrating the variety of exciting careers in science, targeting 11 – 18 yrs • Challenge the perceived stereotype of scientists and their work through awareness • Demonstrate the value of the EU and EU funding structures for collaborative research projects bringing benefit to society • Demonstrate science is an integral part of our culture and heritage An inspirational schools programme, with direct engagement with scientists, targeting those students least likely to engage will open eyes to career opportunities in science. Events will entertain, astound and challenge the 18,000 attending, and will range from dialogue to didactic catering to learning preferences and motivations to attend. Each event will include an EU Corner with assured representation of Horizon 2020 Framework projects and MSCA researchers. Researchers’ will have clear messages to communicate to the audience. They will all receive remote training which will cater for the 500 plus researchers that will be involved in activities, 50 % of which will be female at NHM. In 2018 the museum hosts will connect with European Year of Cultural Heritage. In 2019 Citizen Science will feature heavily in the programme. Evaluation methodology will be shared and results collated by NHM.

Keywords: target audiences,schools 11,18 year olds,night 18,35 year olds
Facing Adiposity in personalizing Treatment of Breast Cancer Patients (FAT-BC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1998620.0
EU funding (EUR): 1998620.0
Participants: 1
Project status: SIGNED

One out of 8 women develops breast cancer (BC) in her lifetime and 1 out of 2 is overweight or obese in industrialized countries. While heavier women have an increased risk of developing BC and heavier BC patients present with worse disease characteristics, BC is so far still treated regardless of patient adiposity because of the limited knowledge accumulated so far. I hypothesize that increased adiposity provides a different ‘soil’ for the tumor cells (the 'seeds') to grow, potentially leading to biological peculiarities of the tumor cells and the cells from the tumor microenvironment. To investigate this hypothesis, I will firstly study the associations between patient adiposity and the genomic and transcriptomic features of the bulk tumor in >2.700 BC patients (FATomics). Secondly, I will complement these findings at the single cell level by creating a comprehensive atlas of BC according to various patient and mammary adiposity measures for the two most common BC histological subtypes (FATlas). Special attention will be given to the mammary fat cells, the adipocytes, and how these help tumor cells to grow and affect treatment efficacy. State-of-the-art technologies such as single-nuclei RNA sequencing, spatial protein visualization and digital pathology will be applied. Thirdly, the FATlas data will be shared with the scientific community through a web-based dataportal (FATshare). Finally, using samples from a prospective in-house clinical trial, I will investigate whether adiposity-associated features are associated with anti-proliferative and/or immune response to immunotherapy and endocrine therapy (FATrial). FAT-BC integrates complementary and multidisciplinary approaches with state-of-the-art technologies and will build upon my expertise in BC biology. The results should lead to the identification of potential strategies to tailor BC treatment according to adiposity, a still unmet clinical need in the context of personalized medicine.

Keywords: breast cancer,obesity,genomics,transcriptomics,immune infiltrates,single cell,single nuclei rna sequencing,clinical trial
encrypted storage device for classified information KOBRA Drive / KOBRA Stick (ESDCI KOBRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In recent years, the growth of hacker and cyber-attacks has significantly increased. As a result of growing threats European Commission, European Council and European Parliament decided to step up their cyber security efforts by reinforcing the new EU cyber security law. The new European GDPR places high demands on the collection and storage of personal data of individuals by public agencies and companies. Authorities and companies’ process data containing sensitive or confidential information. This information may only be stored on authorized media. Currently, there are no external data carriers in the EU or worldwide, which are approved by the BSI being suitable for clearance level such VS-NfD(classified information for official use) or higher. Furthermore, within the EU there is an increased use of PKI (Public-Key-Infrastructure)-based smart cards by government agency and businesses as company ID for the purpose of secure authentication as well as execution of various internal processes and tasks. There are already a few manufacturers of encrypted USB Drives on the market, predominantly based in the US or China. Their products are however not suitable for sensitive data with confidential levels such as VS-NfD or higher. Furthermore there is no solution on the market that allows data carriers to unlock with company IDs. The innovation of DIGITTRADE solves these problems and is called encrypted storage device for classified information KOBRA. It unites two products of new generation: external encrypted hard drive ESDCI KOBRA Drive and the encrypted USB-C stick ESDCI KOBRA Stick. These data carriers are easy to use and can be activated with existing company ID cards. Since its founding in 2005, DIGITTRADE has been involved in the development and production of encrypted data carriers with hardware encryption. In 2017, the HS256S3 became the first hard disk worldwide to receive the IT Security Certificate of the German Federal Office for Information Security(BSI).

Keywords: encrypted storage,protection of classified information,2 factor authentication,pki smartcard and pin,usb hard disk,usb flash drive,hardware based encryption
Blapp, A fun game for the child, an effective tool for the therapist! (BLAPP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Abstract OMADA, a Spanish innovative startup, has developed Blapp, the 1st gamified home rehabilitation platform for Specific Language Impairment (SLI), with validated content based on scientific evidence and highly innovative technologies. Blapp will improve patients’ rehabilitacion anywhere, increasing their quality of life and of their family, while reducing the workload of the therapist and minimizing the burden on healthcare services. SLI affects up to 10% of children and is recognized as the most frequent neurodevelopment disorder in Childhood. Over the past five years, the Speech-Language Pathologists industry has grown by 3.8% to reach revenue of $4bn in 2017. Clinical guidelines recommend intensive daily treatment; however, due to insufficient sanitary resources, cost of treatment, therapist workload and family’s organization, actual therapy is insufficiently done once or twice a week. Blapp will solve this problem transforming therapy activities into an online serious game. The proposed solution has two differential and highly innovative technological features in the field of home rehabilitation: The use of Artificial Intelligent algorithms developed to tailor and adapt the therapy to each particular patient; and Voice Recognition Systems built with Deep Neural Network technology to facilitate patient-platform interaction. The latter is very challenging when treating with children with certain pathologies such as acquired brain damage, cerebral palsy, language disorders, or others. OMADA has already raised European Regional Development Fund (ERDF) funds for early research and technological development. The prototype is showing exceptional results in its first pilot tests. OMADA’s objectives are: to conclude the development phase; to conduct a feasibility study to assess the market potential and define a commercial strategy; to identify potential customers and to define a business plan to attract investors and key commercial partners.

Keywords: voice recognition,serious games,gamification,natural language processing,artificial intelligence,specific language impairment,speech and language disorder,rehabilitation,telemedicine,home care
Ocean Energy ERA-NET Cofund (OCEANERA-NET COFUND)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: ERA-NET Cofund
Partnership: OCEANERA-NET COFUND (ERA-NET)
Countries involved: Spain,Spain,Ireland,Sweden,France,France,Portugal,United Kingdom
Call: Joint Actions towards the demonstration and validation of innovative energy solutions (H2020-LCE-2016-ERA, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 9197015.57
EU funding (EUR): 3035015.1399999997
Participants: 10
Project status: CLOSED

Abstract OCEANERA-NET COFUND aims at coordinating the efforts of 8 agencies, in 4 Member states and 4 regions, in the ocean energy area. The joint action will focus on the demonstration and validation of innovative technologies for the generation of electricity from waves, tidal current, tidal range, salinity gradient and ocean thermal energy conversion, which will lead to improved performance, reliability and survivability of ocean energy conversion devices and arrays, and reduction in the levelised cost of energy (LCOE). The project will comprise: • A Co-funded Joint Call to support transnational, collaborative demonstration projects • A second joint call to support transnational, collaborative research, development, demonstration and innovation projects • Joint activities to improve coordination between national / regional research programmes, coordinate with key stakeholders and promote knowledge transfer and exploitation of results The project aims to build on European industrial leadership to help create a new industrial sector, which has potential to make a significant contribution to the decarbonisation of Europe’s energy system, economic growth, job creation, particularly in peripheral regions. The consortium represents the leading countries and regions in the European ocean energy sector – Scotland (UK), Sweden, Spain, Basque Country (Spain), Ireland, Portugal and Bretagne and Pays de la Loire (France).

Keywords: ocean energy wave tidal
Innovative cancer therapy through Myc inhibition: taking OMO-103 to market (MYCure)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2022-12-31
Duration (months): 43.0
Total project cost (EUR): 6222158.75
EU funding (EUR): 2219553.52
Participants: 1
Project status: CLOSED

Cancer is a global challenge with 9 millions (M) deaths annually and new cases projected to rise by 70% in the 20 years, and there is a clear and pressing need for more effective therapies. In the EU, lung cancer is the most common cancer in men and the third most common in women, with 2 M new cases in 2018 accounting for ~20% of all cancer deaths. Despite considerable recent advances in lung cancer treatment, current treatments are still too often ineffective or highly toxic. Peptomyc is a unique biotech SME that is revolutionizing cancer treatment with its ground-breaking innovative cancer therapies inhibiting Myc. Our patented product OMO-103 is able to penetrate the nuclei, attack Myc and kill cancer cells. In contrast, most current therapies attack redundant cell surface receptors or proteins that can be compensated by tumours, which then evolve resistance. Our company combines scientific excellence with sound business acumen: our scientific leadership in Myc inhibition builds on 20 years of world-class scientific record, and in just 3 years after the foundation, we closed 2 rounds of equity investments with Venture Capitals. Peptomyc aims at licensing its technology to pharmaceutical companies. Financing through this SME Instrument project will enable us to take to the market our first product, OMO-103 by completing clinical trials and reach a licensing agreement with a pharmaceutical company for full scale production and commercialization. Our results so far show that OMO-103 is: Safer (no toxicity), More efficient (no resistance observed), and More effective (increased survival in lung cancer models). With MYCure, we will take to market our first-in-class Myc inhibitor OMO-103 to treat non-small cell lung cancer, for which the global market is expected to reach 14 bn € by 2023, a total addressable market of which OMO-103 is poised to gain considerable share of up to 15% by 2029 thanks to a sound business plan developed under the SME Instrument.

Keywords: lung cancer,cell penetrating mini proteins,myc inhibition