Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PIWI-interacting RNAs at the interface of virus-host conflicts in Aedes aegypti mosquitoes (PIWIdefense)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Background: The mosquito Aedes aegypti transmits viruses with pandemic potential but is also host to a large repertoire of mosquito-specific viruses and endogenous retroviruses. These viruses may invade the ovaries and eventually the oocyte to be transmitted from mother to offspring and to expand in the population. This transmission route exposes them to the specific host defense mechanisms of the ovary, which they must overcome to ensure onward transmission. This intriguing virus–host conflict is crucial for virus evolution and ecology and for host reproduction and survival, but has thus far not been studied. Hypothesis: I hypothesize that a specific class of small RNAs, called PIWI-interacting RNAs (piRNAs), are essential for protection of the mosquito germline from virus infection. Aim: My goal is to define the role of the piRNA pathway as a host defense system against RNA viruses, endogenous retroviruses, and other genomic parasites, and to identify viral counter-defense mechanisms. Additional to these fundamental aims, we will reprogram the piRNA pathway to induce resistance against pathogenic viruses in mosquitoes. Approach: This interdisciplinary project c¬ombines powerful genetic, genomic, and proteomic approaches at the intersection of virology, RNA biology, and entomology. Of particular importance, we will establish urgently needed tools for tissue-specific gene inactivation in vivo to define the functions of the expanded PIWI gene family of mosquitoes. Importance and Innovation: ERC project PIWIdefense will be the first to define host defense functions of the piRNA pathway in the germline of a major vector mosquito. The project generates unprecedented insights into the fundamental processes that shape the fascinating virus–host conflicts in mosquitoes. In addition, the project establishes a novel approach that can be translated into mosquito-centered intervention strategies against arthropod-borne viruses.

Keywords: mosquito biology insect immunity rna silencing
Coastal Climate Resilience and Marine Restoration Tools for the Arctic Atlantic basin (CLIMAREST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Norway,France,Portugal,Ireland,Spain,Italy,Denmark,Belgium
Call: Atlantic and Arctic basin lighthouse - restoration of marine and coastal ecosystems and increased climate resilience (HORIZON-MISS-2021-OCEAN-02, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 8701780.25
EU funding (EUR): 8499998.75
Participants: 18
Project status: SIGNED

The CLIMAREST project - Coastal Climate Resilience and Marine Restoration Tools for the Arctic Atlantic basin - integrates multiple expertise into a holistic approach, to develop a toolbox designed to establish guidelines for ecosystem restoration and to enhance climate resilience in coastal communities. The concept is to develop, test and optimise a modular toolbox that integrates expert knowledge, scientific information, multilevel stakeholder and community involvement, ecosystem service improvement analysis, cost-benefit analysis, priority of actions, and custom designed protocols for restoring and monitoring multiple coastal habitats. The toolbox framework will have common and specific tools that will be tested, optimised and demonstrated in five different ecosystems, across a latitudinal gradient of the Arctic-Atlantic basin, ranging from the high-Arctic Svalbard (79° N) in the North to the Madeira archipelago (33° N) in the South. The variety of environmental conditions and restoration needs of the five demonstration sites will provide different restoration scenarios with particular specificities in terms of biodiversity, pressures and threats, ecosystems services and stakeholders. The diversity in restoration scenarios will create a unique opportunity to develop a modular toolbox, that integrates common tools with tools that are specific for each restoration scenario into a collective framework. Ecosystem-specific innovations in nature-based solutions for habitat restoration that improve local climate resilience will also be developed, tested, and integrated into a general toolbox framework, establishing guidelines and innovative workflows. The toolbox and tools developed in each demonstration site, for different restoration scenarios, will be made available and tested for replication and upscaling in comparable ecosystems and similar communities, with particular emphasis in promoting stakeholder involvement.
Industry CAse studies anaLysis to IMprove EnviROnmental performance and sustainability of bio-based industrial processes (CALIMERO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,France,Belgium,Sweden,Luxembourg,Denmark,Türkiye
Call: Increasing the environmental performance of industrial processes in bio-based sectors: construction, woodworking, textiles, pulp and paper and bio-chemicals (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-07-01
End date: 2025-10-31
Duration (months): 40.0
Total project cost (EUR): 3518900.0
EU funding (EUR): 3518900.0
Participants: 12
Project status: SIGNED

European industries remain a significant source of pollution (51% of GHG emissions), with unsustainable production processes impacting adversely on climate change, natural resources availability, air/water/soil quality, ecosystems services and biodiversity. Thus, a transition to a sustainable and strong bioeconomy is one of the European main priorities as part of the EU Industrial Policy Strategy, the European Green Deal, the 2030 Climate Target Plan and the Bioeconomy strategy. CALIMERO will analyse bio-based sectors industrial case studies provided by partners (construction (ECIA), woodworking (CESEFOR), textiles (TECHTERA, EREKS), pulp & paper (ESSITY) and biochemicals (BIMKEMI)) to find feasible solutions to improve their environmental performance while considering also economic and social aspects. A deep analysis and improvement of the bio-based sectors sustainability performance by sustainability experts (CTA, WELOOP, LIST, IVL NEOVILI), followed by the simulation and modelling of relevant case studies through bio-engineering expertise (DTU) will be conducted to improve current Life Cycle Sustainability Assessment methodologies, based on the Product Environmental Footprint (PEF) guide. To that end, missing characterization factors to assess biodiversity loss, impacts to ecosystem services and toxicity effects of sector-specific substances will be developed. The allocation methods of biotic circular systems will also be improved and the time dimension for lifecycle carbon footprint assessment will be considered. Material criticality and socio-economic indicators will also be included to cover the three pillars of sustainability. The improved methodology will be applied via a Multi Objective Optimization framework that will optimize industrial simulations with sustainability criteria. Finally, guidelines and recommendations addressed to industry, policy makers and scientific community will be developed for industrial sustainable development and monitoring.

Keywords: lcsa,lca,lcc,sustainability
Plasma Medicine against Actinic Keratosis (PlasmACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,France,Netherlands,Belgium,Luxembourg
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2146615.2
EU funding (EUR): 2146615.2
Participants: 16
Project status: SIGNED

The quality of human (and veterinary) health care systems substantially depends on key innovations. Often, these were driven by the field of physics, followed by interdisciplinary and inter-sectorial actions in engineering, chemistry, biology, and medicine, such as X-rays in medical diagnostics, ionizing radiation in cancer treatment, and femtosecond lasers for precision surgery. Medical gas plasma technology was introduced to human health care a decade ago. Today, accredited medical plasma devices are in daily operation in dozen dermatology centers in middle Europe to improve wound healing. In addition, physical plasmas were shown to inactivate cancerous cells. Actinic Keratosis is a skin disease affecting millions of Europeans and making them prone to invasive and deadly skin cancer. Many of the available treatment options are associated with low efficacy, pain, risks, and/or high costs. Medical gas plasma technology is operated at body temperature and applied painlessly, cost-effectively, and without notable side effects. Gas plasma has been suggested to be active on high-grade cancer cells, but its activity against premalignant cells, as in Actinic Keratosis, is unknown. By using beyond state-of-the-art plasma multijet technology, the primary technical objective of PlasmACT – Plasma against Actinic Keratosis – is to support skin cancer prevention by medical gas plasma therapy of Actinic Keratosis. PlasmACT does so by educating a new generation of application-oriented scientists that are exposed to questions and findings from different scientific fields (interdisciplinary from physics over chemistry and biology to medicine) and capable of addressing questions in view of both academic as well as business needs (inter-sectoral) while incorporated in a vivid and productive environment across borders and cultures (international).

Keywords: cold plasma,plasma discharge,plasma medicine,plasma jet,spectroscopy,electric fields,rons,modeling,lipidomics,plasma tissue interaction,cell and redox biology,immunology,dermatology
Unraveling Brassinosteroid Biosynthesis: Orchestrating BR Precursor Movement via Endoplasmic Reticulum-Plasma Membrane Contact Sites (EPCSs) (BRACTION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Since their discovery in 1979, brassinosteroids (BRs) have been extensively studied for their biosynthesis and signalling pathways. Now, in the year 2023, one fundamental question remains: how do BRs move? As the only type of steroidal phytohormones essential for plant growth and development, BRs act in a dose-dependent manner and do not travel long distances. Therefore, BR homeostasis is key to their function. Recent findings in my host lab revealed that in the Arabidopsis root the expression domains of BR biosynthetic enzymes are separated, and the completion of BR biosynthesis requires cell-to-cell movement of precursors, thus, revealing the importance of the short-distance transport for BR homeostasis maintenance. Further we revealed that plasmodesmata (PD) mediate the passage of BRs between neighbouring cells. However, we still do not know where in the cell BRs are synthesized and how these hydrophobic molecules are moving through PD. By searching interactors of BR biosynthetic enzymes, my host lab found interesting candidates associated with the endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCSs), including PD. EPCSs are known lipid synthesis platforms and contribute to PD function in plants. Here, I hypothesize that BRs are synthesized at EPCSs, and EPCSs coordinate BR biosynthesis and transport through PD. In BRACTION, I will combine live cell imaging with state-of-the-art imaging techniques to pinpoint BR biosynthesis sites in the cell. Combining advanced proteomics, genetics, and biochemistry, I aim to identify novel candidates that regulate BR biosynthesis and movement linked to EPCSs. Finally, I will employ genetics combined with bioorthogonal chemistry approach to assess candidate influence on BR symplastic movement. BRACTION's interdisciplinary approach will address knowledge gaps in BR homeostasis and drive major conceptual advances in understanding how BR levels are maintained across different cell types and tissues.

Keywords: brassinosteroid biosynthesis symplastic transport endoplasmic reticulum plasma membrane contact sites advanced imaging protein protein interactions
Electron Capture in Ho-163 - Large Experiment (ECHo-LE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2431617.0
EU funding (EUR): 2431617.0
Participants: 3
Project status: SIGNED

The discovery of the neutrino mass scale is a milestone for shaping the extension of the Standard Model of Particle Physics. Experiments looking at the endpoint region of low energy beta decay and electron capture spectra benefit from a clear signature of massive neutrinos which only depends on energy and momentum conservation. Along with the well-established use of tritium, as in the KATRIN experiment where the present best limit of 0.45 eV at 95% CL was reached, two collaborations, ECHo and HOLMES have pioneered the use of Ho-163. In both experiments, low temperature microcalorimeters enclosing the Ho-163 source are used. Both collaborations have demonstrated the suitability of Ho-163 for a large experiment. The project ECHo-LE (ECHo-Large Experiment) will be built on the hardware and on solid results obtained with the ECHo experiment and will feature large arrays of metallic magnetic calorimeters where each detector encloses Ho-163 for an activity of 10 Bq. A new cryogenic multiplexer which ensures a homogeneous performance will be used for the readout. On-line data reduction and will be developed to allow for a limited saving space. Following the data analysis developed for the ECHo experiment, new fitting procedures will be tested to reduce the effects of systematic uncertainties. The experiment, consisting of 20000 detectors with gaussian detector response having full width at half maximum of less than 5 eV, will be built in the first two years of the project. After installation, the experiment will run for at least two years. The goal is to acquire more than 10 billion Ho-163 events. The analysis of the data will allow for significantly improving the knowledge of the Ho-163 spectral shape parameters and clearly search for an effect of a finite neutrino mass. ECHo-LE will be the first Ho-163 based experiment able to reach sub-eV/c2 sensitivity on the effective electron neutrino mass and set the basis for the ultimate Ho-163 based experiment.

Keywords: neutrino mass,ho 163,low temperature microcalorimeters
Miniature Trace Gas Analyzers with FFP microcavities (MiTrA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-10-01
End date: 2025-10-31
Duration (months): 25.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Fiber Fabry-Perot (FFP) microcavity technology developed in the ERC project EQUEMI enables hand-held gas analyzers based on cavity-enhanced laser spectroscopy with a combination of small size and high performance that does not exist in any commercial instrument today. Furthermore, the FFP principle also enables fiber-coupled arrays of cost-effective, passive remote sensors read out by one central unit using scalable fiber multiplexing technology developed for the telecom market. Both features enable fast, easy and cost-effective emission measurements of GHG and other trace gases in areas where they are not practically feasible today. Finally, the microscopic size of FFP cavities means that extremely small gas samples (below one microliter cavity volume) can be analyzed and high bandwidth can be achieved with low gas throughput. Here we propose to demonstrate the performance of such instruments by building a demonstrator for methane detection, investigate market potential and prepare commercialization with a team of founders that is already in place.
TACKLING ANTIBIOTIC OVER-PRESCRIPTION (OVER-AB)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Netherlands
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-09-01
End date: 2024-08-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Within the ever changing and ever innovative field of healthcare diagnostics, ShanX Medtech and Dr. Sophia Eriola Shanko are dedicated to bringing personalised diagnostic testing to the point-of-care, ensuring the timely and appropriate administration of antibiotics to patients. Worldwide over 400 million people visit their doctor with a Urinary Tract Infection (UTI) every year. With the majority of UTIs stemming from a bacterial infection, the treatment thereof is straightforward: an antibiotic prescription. However, for physicians determining the correct antibiotic treatment for each patient remains problematic. Furthermore, the global increase in antibiotic resistance rates reinforces the need to improve antibiotic prescription protocols. ShanX is developing a diagnostic tool that can be used at the doctor's premises and it allows the physician to test a series of antibiotics prior to administration, thereby ensuring the subsequent treatment efficacy. The results provided are fast, accurate, and tailored to each individual patient. ShanX Medtech is revolutionizing the antibiotic treatment workflow by enabling fast, evidence-based and personalized antibiotic administration. Sophia is proudly building a world where women, like herself, are defining and designing a better future for patient care. She hopes that her positivity and charisma serve as an inspiration to others, and that – while leading by example – true passion paired with determination and grit, can empower women to meet their potential and pursue entrepreneurship.

Keywords: point of care testing,femtech,medtech,in vitrod iagnostics,female entrepreneurship
AI-driven cognitive supply chain forecasting & planning solution for industrial manufacturers (Flowlity)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Manufacturers are facing volatile & stretched supply chains, large volumes of data, raw material shortages, requests for JIT fulfilment, & pressure from e-commerce. Poor inventory management causes billions in losses as a result of overstock & product shortages while the global pandemic is adding a new layer of complexity to supply chain planning. Flowlity brings a resilient planning solution to the Supply Chain 4.0 market—a complement to Industry 4.0 in which networked technologies & digital tools accelerate, enhance & optimise supply chains. Our AI algorithms for demand forecast, network approach, and flow-based inventory optimization enable 30-60% stock reductions & 10-60% fewer stockouts for our customers. We aim to become the European leader in supply chain management solutions for industrial manufacturers. Within 5 years, we will be serving 1K+ manufacturing companies in the automotive & aerospace industries, generating €41M ARR & employing 230 people across Europe & USA.

Keywords: supply chain management,demand forecasting,inventory optimization,resilient planning,next gen supply chains,artificial intelligence