Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Grid Forming Loads to provide maximum flexibility and enable future power systems with very high renewable generation penetration (GridForLoads)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Spain,France,Austria,Greece,Switzerland
Call: Emerging energy technologies for a climate neutral Europe (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 2499812.5
EU funding (EUR): 2499812.5
Participants: 7
Project status: SIGNED

Modern power systems are experiencing a deep transformation motivated by the massive deployment of renewable energy generation, the irruption of electrical mobility and the digitalization of the energy systems. In traditional power systems, power balancing is provided by conventional power plants that are capable of adjusting the power injection. However, the recent massive deployment of variable (non-dispatchable) power-electronics interfaced renewables, mainly solar photovoltaics (PV) and wind power, has brought a very important challenge and demands to rethink how the whole power system needs to be designed, operated and protected. Solar PV and wind have limited flexibility compared to other technologies which store the prime resource. The flexibility can be provided by operating these non-controllable renewables below the point of maximum power generation (with the associated loss of generation), using energy storage or with demand management. In addition to power balancing, it is also required to provide grid services and forming the grid ensuring stability. While this is traditionally provided from the generation side, this project focuses on providing these functionalities from the loads, thus developing the concept of Grid Forming (GF) Loads and allowing renewable generators to operate at the point of maximum power availability. The project objectives include the concept definition, selection of loads, development of controllers, implementation in relevant applications (electrical vehicle chargers, pump drives, railway power systems), systems studies and techno-economic and environmental studies on the impact. The project is structured in seven work packages and includes experimental validation of the concept in selected loads and overall systems studies.

Keywords: grid forming,demand management,grid integration of renewables
Decoding subcellular spatial biology with high precision using RNA photocatalysts (RNAPhotoCat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999525.0
EU funding (EUR): 1999525.0
Participants: 1
Project status: SIGNED

RNA is a fundamental component of life. Complex, dynamic, and spatial networks of molecular interactions between RNAs and other biomolecules are essential for maintaining cellular homeostasis. Disruptions in the RNA interactome have been linked to a number of human diseases, implying that these molecular interactions could represent a new family of unexploited therapeutic targets. Despite the growing appreciation of the importance of RNA, discovery, and characterization of RNA interactions at the transcriptome level is lagging behind, mainly due to the limitations of the existing methods including low precision, low throughput, low coverage, biased analysis, complicated protocols involving cumbersome biochemical fractionation or cell-line engineering. With the present technology, many more years may pass before a comprehensive list of their functions, localizations, and interactions can be assembled, considering the immense size and complexity of the human transcriptome and RNA interactome. This ERC project aims to establish a simple, versatile, and low-cost technology based-on photocatalytic proximity-labeling and the biRhoBAST aptamer for deciphering RNA-RNA and RNA-protein interactions with high precision for any given RNA at different resolutions, ranging from single-molecule to macromolecular complex level. Owing to its innovative design, this technology will seamlessly integrate with advanced super-resolution RNA imaging techniques, providing valuable insights into the intricate interaction networks of RNA with high temporal and spatial resolution. By applying this massively multiplexable technology to numerous biological settings and disease-related RNAs, we will expand our understanding of interactomes, uncover new insights into subcellular RNA structures and unravel fundamental molecular mechanisms of RNA diseases, leading to the discovery of novel functions for both RNA and proteins, and potentially unlocking new therapeutic targets.

Keywords: rna imaging,super resolution microscopy,probe,fluorophore,rna interactome,proximity labeling
Demonstrating trAnsformative solUtions to empower climate Resilience tOwards impRoved public health stAtus in the EU Boreal Region (AURORA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Belgium,Lithuania,Finland,Latvia,Estonia,Sweden,Cyprus,Germany,Romania,Switzerland
Call: Testing and demonstrating transformative solutions to build resilience towards health risks caused by the effects of climate change (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2024-09-01
End date: 2028-02-29
Duration (months): 42.0
Total project cost (EUR): 7208824.32
EU funding (EUR): 6099870.0
Participants: 26
Project status: SIGNED

Climate change poses significant threats to human health and well-being, impacting not only the EU Boreal region but also Europe as a whole. The increasing frequency and severity of extreme events, like floods, wildfires, rising sea levels, and heatwaves have far-reaching consequences for local communities. The need to adapt to climate change's impacts and embrace transformative solutions has garnered recent political attention. Nevertheless, recent extreme incidents, such as the 2021 wildfires in the Boreal region and similar events in Europe, have underscored the imperative of systemic actions and revealed the disproportionate vulnerability of already marginalized populations. The AURORA project aims to enhance resilience against health risks stemming from climate change and contribute to the overarching Mission objectives. It seeks to achieve this by developing a suite of tools capable of: 1) Monitoring climate stressors, 2) Creating climate and epidemiological models 3) Generating forecasts via simulated scenarios 4) Identifying climate change risks and vulnerabilities in the Boreal region. These risks will be complemented by a reliable AI-driven technology that will 5) Issue early warnings and recommend adaptive measures and nature-based solutions. These components will form a robust Decision Support system providing specific recommendations. The AURORA consortium, with its vast experience in research projects, envisions active engagement with stakeholders throughout all project stages via an Implementation Hub. This engagement aims to foster behavioral change and showcase the project's solutions in 5 Demo cities (Riga, Tallinn, Vilnius, Tampere, Pori ) and 3 replicant cities (Klaipeda, Joniskis, Jurmala). The knowledge and insights generated by AURORA will be disseminated through clustering activities, ultimately empowering local policymakers to make evidence-based decisions, reassess strategies, and develop management plans for climate-resilient cities.

Keywords: climate change and health impacts,risks,vulnerabilities,epidimiological modelling,natural based solutions,
Empowering Widening universities in EUTOPIA_HEALTH consortium to foster academic excellence in Health (EUTOPIA_HEALTH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Romania,Slovenia,Portugal,Belgium,Spain,France,Italy,Sweden,United Kingdom
Call: European Excellence Initiative (HORIZON-WIDERA-2023-ACCESS-03, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 4999960.0
EU funding (EUR): 4999960.0
Participants: 9
Project status: SIGNED

Challenges in Health require integration of knowledge and communication between specialists from different health-related fields to develop effective solutions. The EUTOPIA_HEALTH project, a EUTOPIA_HEALTH consortium initiative, aims to create a novel and innovative framework for the integrative academic management of health-related scientific areas, facilitating changes in the academic landscape within the European research area, through a comprehensive institutional transformation. The project targets three Widening countries (Romania, Slovenia, Portugal) of the consortium, that have traditionally lagged behind in health-related domains, striving to overcome funding and publication disparities, and spearheading academic excellence and innovation in these critical domains. Therefore, the project aims to empower institutional transformation by strengthening health-related R&I management capacity, upgrading and adapting R&I management strategies and policies within Widening HEIs of the project consortium in line with the principles of the European research assessment reform. A health-focused R&I network within EUTOPIA_HEALTH consortium will be established through Connected Health Research Communities, that will receive inter/transdisciplinary trainings, research mobilities for early-career researchers and seed-funding for research collaborations, all centered around health-related challenges. By employing integrative, transdisciplinary approaches and implementing flexible academic career pathways in Health, the project focuses on creating a Health innovation ecosystem bridging the Health research communities to society, business partners, and policymakers by mainstreaming Open/Citizen/Inclusive/Collaborative Science practices and translating research into tailored social innovation supported solutions. EUTOPIA_HEALTH project, through its comprehensive activities, will positively impact the R&I achievements, research excellence, international visibility, funding absorption rate of the Widening consortium HEIs and of entire EUTOPIA_HEALTH consortium.

Keywords: integration,transdisciplinary,innovation,clusters of excellence,connected research communities
Young Universities for the Future of Europe - Postdoc programme (YUFE4Postdocs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Belgium,Spain,Finland,United Kingdom,Netherlands,Croatia,Poland,Cyprus,Germany
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 7307280.0
EU funding (EUR): 7307280.0
Participants: 18
Project status: SIGNED

YUFE4Postdocs (Y4P) is an ambitious and novel postdoctoral training programme, launched by the Young Universities for the Future of Europe (YUFE) Alliance in the context of its R&I Agenda. Under the overarching theme ‘Urban opportunities & challenges in the 4 YUFE Focus Areas’, two calls will result in the appointment of 51 excellent researchers across 10 universities. Stakeholder interactions, Open Science and interdisciplinarity run as a red thread throughout the programme, which is centered around community engagement. Y4P offers attractive employment conditions, including 36-month appointments and competitive remuneration. Its selection process pilots a novel approach by assessing applicants on a broader and qualitative set of selection criteria, with extensive involvement of external stakeholders. The unique 3-pillar training programme features interactive stakeholder engagement seminars (Pillar 1), combined with a variety of joint transferable skills trainings (Pillar 2) and complementary partner courses (Pillar 3). A triple-I mobility scheme is set in place, covering 6-month intra-YUFE mobility, optional intersectoral secondments, and encouraged interdisciplinary cooperation. Each postdoc is supported by a triad of supervisors, with a Career Development Plan as their individual roadmap. Under the coordination of UAntwerpen, the consortium unites the 10 YUFE Partners with 19 cities, regions and business organisations as Associated Partners, and can benefit from their extensive experience - in full synergy with YUFE’s existing project portfolio (incl. YUFERING, DIOSI and Inno4YUFE). Overall, Y4P will (1) empower future proof researchers, skilled to work in interdisciplinary environments and with access to various career pathways; (2) spur bottom-up bilateral and multilateral collaboration across the Alliance; (3) set a new standard for next generation postdoctoral research training; (4) accelerate the development of a true European (research) University.

Keywords: innovative training,stakeholder interaction,urban challenges and opportunities
Reprogramming lung epithelial cell lineages for regeneration (LungDeCode)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 2499986.0
EU funding (EUR): 2499986.0
Participants: 1
Project status: SIGNED

In chronic adult lung diseases both tissue homeostasis and repair are disrupted, regeneration mechanisms fail, and healthy cells are replaced with aberrant cells. My long-term vision is to overcome these problems in patients with early-stage lung disease by in vivo reprogramming of cell fate to induce regeneration and restore cellular homeostasis. To achieve this we will move beyond the current state-of-the-art for human lung cell culture and human lineage-tracing, employing new physiologically-mimetic culture methods optimised in my lab which allow the ecosystem of cell states present within a tissue to be interrogated together. Focusing on interstitial lung diseases, which are primarily caused by epithelial dysregulation, we will acquire the biological framework to test the hypothesis that intrinsic cell reprogramming can promote human lung regeneration. We will determine how the lineage-dynamics of complex airway epithelia vary with airway generation in development, homeostasis and chronic hypoxia, which is a consequence of multiple lung diseases. This crucial information will be pivotal for inducing cell fate transitions that follow naturally occurring cell lineages, which will be the most efficient and stable routes for reprogramming in the adult. In parallel, we will ‘decode’ lung cell fate by defining the gene regulation networks controlling differentiation, proliferation and quiescence of human lung epithelial cell types. This will allow us to predict, and functionally test, factors sufficient for cell fate reprogramming. These experiments will combine innovative human tissue models, novel genetic tools and systematic analyses of scRNA-seq data. These analyses of precise cell lineages and transcription factor codes will allow us to test whether in vivo reprogramming of cell fate to induce regeneration is feasible. Our data will also provide an essential framework for building advanced human tissue models.

Keywords: lung,epithelial,lineage tracing,scrna seq
Spatio-temporal shaping of electron wavepackets for time-domain electron holography (eWaveShaper)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1835895.0
EU funding (EUR): 1835895.0
Participants: 1
Project status: SIGNED

Advanced techniques of electron microscopy and spectroscopy require tools, which enable to control various degrees of freedom of electron beams (phase profile, temporal structure, orbital angular momentum, etc.). The inelastic quantum coherent interaction between light waves and electron wavepackets allows to structure the temporal probability distribution of electrons with attosecond precision, which may enable probing the coherent dynamics of optical excitations or plasmonic near-fields of nanostructures and metamaterials. Up to now, only electron-photon interactions mediated by solid-state structures have been considered, which have severe limitations. In this project I will develop a versatile tool for quantum coherent shaping and full characterisation of the phase profile and amplitude of the electron wave function in electron microscopes. The interaction will be mediated by the ponderomotive potential of spatio-temporally shaped light fields in vacuum. The electron wavepackets will be controlled on nanometer spatial and sub-femtosecond time scales that are natural for light waves. The optical coherence imprinted to the electron wavepackets will be exploited in two ways: i) I will explore the possibility to transfer the temporal coherence from density-modulated electron wavepackets to radiation and bound electron excitations in two-level quantum systems by detecting phase-resolved cathodoluminescence and coherent Smith-Purcell radiation driven by swift electrons. ii) I will introduce time-domain electron holography, which will exploit the temporal coherence of shaped electron wavepackets for phase-resolved imaging of optical excitations in nanostructures. The approaches proposed in this project open new pathways for electron-mediated optical quantum-coherent control and spectroscopy with atomic spatial resolution.

Keywords: electron microscopy,quantum control,electron holography
Evolutionary dynamics of genomic erosion and its application in biodiversity conservation (ERODE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Reducing biodiversity loss is one of the most pressing societal challenges of our time. Population decline has put many species on the path of collapse and extinction. Reducing or reversing this decline is not enough to tackle the associated hidden evolutionary costs, most notably genomic erosion which compromises the long-term viability and resilience of species. ERODE will employ state-of-the-art approaches – (paleo)genomics, quantitative genomics, and evolutionary modelling – to assess the dynamics of genomic erosion on neutral, beneficial, and deleterious variation and understand its effects on organismal fitness, population viability, and extinction risk. I will perform one of the most comprehensive genome-fitness studies to date by examining the fitness effects of genomic erosion over time in 6,530 individuals of three iconic endangered bird species for which I have access to over 30 years of genetic samples and fitness data. Together with zooarchaeological and museum-preserved samples, I will draw a dynamic timeline of genomic erosion in response to population decline. Next, I will develop a modelling framework parametrized and validated with empirical data to predict the consequences of genomic erosion. I will use this framework to understand the efficacy of in-situ and ex-situ conservation strategies in collaboration with The European Association of Zoos and Aquaria (EAZA). The computer model will incorporate genomics into the Green Status of Species to evaluate species recovery and conservation impact, in collaboration with members of the International Union for Conservation of Nature (IUCN). ERODE will produce one of the largest genomic datasets for endangered species in the world and a robust modelling framework for conservation scientists and practitioners. The outputs will be disseminated in academic journals but also over a series of workshops, instruction videos and other outreach activities, which will support their practical application.

Keywords: conservation biodiversity genomics modelling predicting forecasting management endangered birds genetic load functional variation neutral variation