Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of Cdc42 in cancer cell adhesion to endothelial cells and platelets (Cdc42Adhere)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-11
End date: 2017-05-10
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Metastasis accounts for 90% of cancer deaths, and it is therefore important and timely to identify new therapeutic targets aimed specifically at metastasis. Cdc42 has recently been implicated in a key step of the metastatic cascade: the extravasation of circulating tumour cells, also termed transendothelial migration (TEM) . This project aims to study how Cdc42 contributes to breast cancer cell TEM in vitro and in vivo. Cdc42 regulates β1‐integrin expression via the transcription factor serum response factor (SRF) and thereby stimulates cancer cell adhesion to endothelial cells (ECs) and TEM. To analyse the molecular basis for this regulation, downstream targets of Cdc42 will be depleted by RNAi in a panel of breast cancer cells to determine which target/s are responsible for altering β1‐integrin expression, adhesion to ECs or TEM. Cancer cells interact with platelets as soon as they enter the bloodstream, and this enhances cancer cell TEM in vivo. It is therefore possible that Cdc42 regulates attachment to platelets as well as ECs. The role of Cdc42 in the interaction between platelets and cancer cells will be tested by adding purified platelets to control or Cdc42‐depleted breast cancer cells in vitro and analysing platelet aggregation around cancer cells by confocal microscopy. The role of Cdc42 in platelet attachment to cancer cells during early lung colonization in vivo will be studied by intravenous injection of fluorescently tagged breast cancer cells in mice. This project will increase our understanding of metastasis. The identification of molecular targets involved in cancer cell extravasation will provide a starting point for the development of new drugs, thus contributing to reduce the mortality of patients with metastasis.

Keywords: rho gtpases,integrins,cdc42,cell adhesion,endothelial cells,breast cancer,transendothelial migration,cytoeskeleton,platelets
How do infants mentalize? Bringing a neuroimaging approach to the puzzle of early mindreading. (DEVOMIND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1761190.0
EU funding (EUR): 1761190.0
Participants: 1
Project status: SIGNED

Human social interaction and learning depends on making the right inferences about other people’s thoughts, a process commonly called mentalizing, or Theory of Mind, a cognitive achievement which several decades of research concluded was reached at around age 4. The last 10 years has radically changed this view, and innovative new paradigms suggest that even preverbal infants can think about others’ minds. This new developmental data has created arguably one of the biggest puzzles in the history of developmental science: How can infants be mentalizing when years of research have shown that a) pre-schoolers fail at mentalizing tasks and b) mentalizing depends on the development of cognitive control, language, and brain maturation? The key issue is whether behaviour that looks like infant mentalizing really is mentalizing, or might infants’ success belie alternative processes? The most powerful strategy for resolving this puzzle is to look to brain activity. By applying the same methods and paradigms across infancy and early childhood, DEVOMIND will investigate whether infants’ success on mentalizing tasks recruits the same network of brain regions, and neural processes, that we know are involved in success in older children and adults. In the second half of the project, we will use our neural indicators of mentalizing to test a completely novel hypothesis in which infants’ success is possible because they have a limited ability to distinguish self from other. Although novel, this hypothesis deserves to be tested because it has the potential to explain both infants’ success and preschoolers’ failures under a single, unified theory. By bringing a neuroimaging approach to the puzzle of early mentalizing, DEVOMIND will allow us to move beyond the current impasse, and to generate a new theory of Theory of Mind.

Keywords: infants,mentalizing,theory of mind,neuroimaging,social cognition,social neuroscience
The evolutionary genetics of transposable element invasions (TE_INVASION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2026-04-30
Duration (months): 84.0
Total project cost (EUR): 1991315.0
EU funding (EUR): 1991315.0
Participants: 1
Project status: SIGNED

Transposable elements play major roles in the genome evolution of eukaryotes, and cause harmful mutations, deleterious side effects, and disease. These costs drive their eukaryotic hosts to evolve counter-adaptations, which are so effective that TEs are thought to only survive long term by invading new naïve species. These transposable element invasions appear to occur via horizontal transfer, and can result in the rapid, selfish spread of the element through a species. Despite the evolutionary importance of the host-transposable element relationship, there are still major gaps in our knowledge of how they evolve and persist. Host resistance can evolve astonishingly rapidly, but the evolutionary mechanism by which this happens is unknown. Some horizontal transfer events result in successful invasions, but we have little idea of what factors favour success, or, except in rare cases, how the transfer events occur. This proposal outlines a four-part research programme to address these gaps, examining both sides of the coevolutionary equation. Specifically, I will examine the rapid evolution of suppression from the host side, to understand the population genetics of this process. I will study invasions from the perspective of the transposable element, and ask what genetic factors contribute to their success. To accomplish these objectives, I will take advantage of a unique opportunity-- an ongoing invasion of a model transposable element in a close relative of the genetic model fly. Finally, I will examine the role of parasites as vectors of TEs ,to understand mechanisms of horizontal transfer between species.

Keywords: transposable elements,drosophila
TRAPEZE - TRAnsparency, Privacy and security for European citiZEns (TRAPEZE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Germany,Belgium,Belgium,Serbia,Greece,Belgium,France,France
Call: Digital Security and privacy for citizens and Small and Medium Enterprises and Micro Enterprises (H2020-SU-DS-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 6017950.0
EU funding (EUR): 4995812.5
Participants: 13
Project status: SIGNED

The TRAPEZE project aims to drive a cultural shift in the protection of the European data economy by weaving trust into its very foundation and reconstructing the concepts of control, transparency, and compliance through technical and methodological, citizen-first, innovations. Driven by the needs of three distinct real-world use cases, TRAPEZE brings together over a decade worth of EU-funded research in security and privacy, as well as proprietary solutions and know-how, towards realistic and marketable solutions. We will develop technologies which: (i) empower citizens with the necessary tools and know-how to manage their security and privacy and actively contribute to the cyber resilience of the common European data space; (ii) enforce the integrity and nonrepudiation of citizens’ data usage policies and processing across data sources and controllers’ borders; (iii) dynamically acquire citizens’ consent and adjust their data policies in real time in response to their changing circumstances; (iv) protect citizens’ online communications and applications running on their personal devices against malicious agents; and (v) provide citizens, as well as other relevant stakeholders (including controllers, CERTs/CSIRTs, and data protection authorities) with a comprehensible overview of transborder data lineage and flows, as well as proof of legal compliance, even in big data environments. By relying on Linked Data and Blockchain, TRAPEZE will lead the way in putting the often-misplaced cutting-edge technologies to practical use and become a lighthouse for European and global initiatives aiming to deliver privacy-aware innovations. Finally, to ensure citizens of all groups can have an active role in the protection of their data flows, TRAPEZE will place a special emphasis on usability and co-production, involving European citizens directly in the development of its security- and privacy-enhancing technologies.

Keywords: transparency,compliance,privacy enhancing technologies,linked data,gdpr,data protection
Force/position control system to enable compliant manipulation from a floating I-AUV (IAUVcontrol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The aim of this project is the design and implementation of a control system for an intervention autonomous underwater vehicle (I-AUV), composed of an AUV equipped with a multi-degree-of-freedom (multi-DOF) manipulator, to enable it to perform fully autonomous compliant underwater manipulation. During this fellowship the experienced researcher will implement algorithms based on dynamic control/force control and perform extensive experimental trials with the real system, to present results beyond the state of the art. This research is aimed to: (1) develop a dynamical model of the system to be able to use model-based control approaches (2) extend the underwater robot simulation software used in the lab to include manipulator dynamics (3) select the most appropriate control algorithm or a combination of algorithms to realise active compliance (4) develop the control system utilising control theory and simulation (5) extend the capabilities of the robot manipulator (6) implement the control system on the robot (7) perform extensive experimental trials in realistic scenarios, in the test tank and in the sea (port) (8) write a proposal for the funding of the next stage of the research. The experienced researcher will broaden his knowledge to the fields of modeling and identification of unmanned underwater vehicles (UUVs), mechanical design of underwater equipment, mapping and localisation in the underwater environment as well as operating UUVs in the sea. He will be able to work on a one-of-a-kind Girona500 I-AUV. He will also be involved in the supervision of research projects of Master students and a new PhD student. With the supervision of Dr. Pere Ridao, the researcher will hone his proposal writing skills. All of this will ensure, that with the help of this fellowship, the experienced researcher will reach professional maturity and independence. Moreover, the vast network of contacts in the field that the UdG has collected will open up many career possibilities.

Keywords: robot,underwater robotics,autonomous underwater vehicle,manipulation,compliance,force control,position control,dynamic control,intervention,experimental validation,floating manipulation
High Temparature concentrated solar thermal power plan with particle receiver and direct thermal storage (NEXT-CSP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Belgium,France,France,France,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2021-07-31
Duration (months): 58.0
Total project cost (EUR): 4947420.0
EU funding (EUR): 4947420.0
Participants: 10
Project status: CLOSED

According to the Integrated Roadmap of the Set-plan, and to reach the new EU target of 27% of renewable energies in 2030, there is the need to rapidly expand the use of all renewable energy sources in Europe to accelerate the fight against global climate change. This requires the acceleration of development of new options that are emerging today, particularly, technologies that solve the key issue of energy storage. The next-CSP Project is a response to this need and addresses significant improvements in all three elements targeted by the LCE-07-2016 call related to concentrated solar power: heat transfer fluids, which can be used for direct thermal energy storage; the solar field; and high temperature receivers allowing for new cycles. The proposed fluidized particle-in-tube concept is a breakthrough innovation that opens the route to the development of a new generation of CSP plants allowing high efficiency new cycles (50% and more) and 20% improvement of CSP plant efficiency. The Next-CSP technology that cumulates the know-how acquired during the CSP2 FP7 EU project on the particle-in-tube technology can be rapidly cost-competitive and introduced in the market. A cost reduction by 38% is expected with respect to current CSP electricity cost. The project will demonstrate at industrial pilot scale (TRL5) the validity of the particle-in-tube concept atop the Themis facility solar tower. A 4-MWth tubular solar receiver able to heat particles up to 800°C will be constructed and tested as well as the rest of the loop: a two-tank particle heat storage and a particle-to-pressurized air heat exchanger coupled to a 1.2 MWel gas turbine. A commercial scale power plant (150 MWel) will also be designed on the basis of experimental and simulation results and associated costs assessed. The consortium includes 6 companies that will lead the development of the first worldwide demonstration of this innovative technology and pave the way for future commercial exploitation.

Keywords: concentrated solar power,solar thermal electricity,solar field,high temperature solar receivers,innovative heat transfer fluid,particle technology,industrial pilot scale demonstration
DHaptics: Creating silent and sharp Mid-air Haptics using phased array of ultrasound transducers (DHaptics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom,United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2014-12-01
End date: 2016-05-31
Duration (months): 18.0
Total project cost (EUR): 149170.0
EU funding (EUR): 83797.5
Participants: 2
Project status: CLOSED

A fundamental shift is underway in how we interact with our computers and devices. Products such as Microsoft’s Kinect and Leap Motion’s desktop controller enable us to dispose of the keyboard and mouse and instead control our devices without touching them. Touchless sensing products are being launched across the consumer electronics, automotive and healthcare industries. A significant and well noted problem with touchless sensing is a lack of tactile feedback. The PI and his team are the first in the world to create a novel haptic feedback system that allows users to feel tactile sensations in bare hand while interacting in mid-air with a system. This is likely to be a huge commercial success provided we can make some improvements to the distinct audible hum that is generated by our system. This project will realize a proof of concept phased-array haptic system that is silent and sharp. Our prototype will enable two advantages over the existing haptic system. a) Elimination of audible noise when creating a single and multiple tactile points b) Maintaining perceptual sharpness of the tactile focal point while eliminating the audible sound

Keywords: haptics,human computer interaction,interactive systems,gaming devices,consumer electronics
LearnIng from Failure in a collaborative Entrepreneurship network (LIFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Germany,Spain,Estonia,Spain,Finland,Croatia,Lithuania,Norway,Belgium,France,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Web Entrepreneurship (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 413125.0
EU funding (EUR): 413124.5
Participants: 15
Project status: CLOSED

The LIFE project is about collaborative learning from failure in entrepreneurship and collaborative actions to bring entrepreneurship forward. Although cultural diversity is one of Europe’s biggest assets, this also creates severe obstacles for entrepreneurs to scale their efforts at the pan-European level. The distributed markets, language barriers and decentralized policy leads to: lack of access to talent & relevant expertise, to sufficient financing and to adequate facilities & networks. Hinged on a yearly Failing Forward conference, the project will - map out all the relevant stakeholders and programs in each of the partnering areas in a systematic way, making this available to all web entrepreneurs across Europe in one centralized platform, - identify, share and discuss best practices & success stories This yearly pan-European conference in Brussels will be complemented with local spin-off events in the partner regions, to - generate and grow awareness that failure is an inherent part of the process of entrepreneurship and innovation; - share and celebrate the success stories that were built on incremental learning; - open up the existing startup support programs to web entrepreneurs from all over Europe

Keywords: european entrepreneur ecosystem,learning from failure
Wearable technology for the selective detection and continuous monitoring of movement disorders related to Parkinson’s disease (PD-Watch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Both the diagnosis of PD and the assessment of its time course are essentially clinical and based on performing neurological examinations and simple motor tests. However, these examinations only assess the state of the PD patient’s health throughout the duration of the testing, which is limited in time, and thus fail to detect fluctuations in motor symptoms, which can vary considerably throughout the day and from one day to the next. In order to reduce these disadvantages, Biomedical Lab has developed the PD-Watch, which is a wearable device, configured as a wristwatch, for continuous and long-term monitoring of movement disorders. The information on tremors and other Parkinsonian symptoms are detected via the accelerometer positioned on the wrist and subsequently processed. The value proposition of the PD-Watch is to provide a powerful tool and an innovative solution to identify the best possible treatment specific to each patient that will minimise PD motor symptoms. The PD-Watch has an improved ability to discriminate motor activity due to movement disorders of a neurological origin from the actions and movements performed daily by the patient. The PD-Watch has already been tested during a preliminary clinical trial and is protected from an intellectual property standpoint.

Keywords: ehealth,healthcare system,information and communication technology ict,scientific,computing,digital services,wearable technology