Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Disruptive fluorescent technologies for inflammatory bowel diseases (IBDIMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders causing inflammation of the gastrointestinal tract, which affect around 3 million patients in the EU. Current monitoring of IBD is mainly performed in the form of colonoscopies, biopsies or tests which are invasive or cannot specifically report on IBD activity. There is a need for new technologies that can rapidly measure activity biomarkers of IBD and enable the monitoring of disease progression and response to therapy accurately. This unmet patient need is what drives the development of this ERC PoC project. The ERC CoG DYNAFLUORS (Dynamic Activatable Fluorophores) project was funded to develop the first chemical toolbox for imaging the activity of immune cells in real time. In IBD, the activity of immune cells are important indicators of the disease state and can be used to assess how patients respond to therapy. DYNAFLUORS measure real-time immune cell activity; hence they are optimal tools to monitor disease progression in IBD patients facilitating a more accurate and personalised therapeutic approach. Based on our promising results in the ERC CoG, we aim to develop DYNAFLUORS into a new fluorescent technology for imaging IBD activity which will lead to: 1) new tools for IBD research and drug discovery in collaboration with companies covering the global fluorescent reagent market as well as Pharma, and 2) point-of-care technologies for clinical diagnostics in IBD patients. Funding from the ERC PoC will allow us to commercialise fluorescent reagents for research, in vitro diagnostics and drug discovery as well as to establish the foundations for new translational technologies to measure IBD activity in patients. This project will be guided by input from existing and new industrial and clinical partners and will create numerous opportunities for accelerating the research, diagnosis and treatment of IBD.

Keywords: fluorescent probes,peptides,fluorophores,inflammation,immunology,diagnostics
SUSTAINABLE PLANT PROTECTION TRANSITION: A GLOBAL HEALTH APPROACH (SPRINT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Italy,Italy,Germany,Spain,Spain,Italy,Argentina,Germany,Switzerland,Belgium,Slovenia,Switzerland,Croatia,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,Portugal,United Kingdom
Call: Integrated health approaches and alternatives to pesticide use (H2020-SFS-2019-2, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 14994445.0
EU funding (EUR): 14994445.0
Participants: 28
Project status: SIGNED

SPRINT will develop and validate a Global Health Risk Assessment Toolbox to integrate assessments of the impacts of plant protection products (PPP) on ecosystem, plant, animal and human (EPAH) health, using three main attributes for health status: resilience, reproduction/productivity and manifestation of diseases. The goal is integrated risk assessment at the local, regional, national and European level, focusing on different PPP use patterns and detected residue mixtures in contrasting farming systems (conventional, integrated, organic). SPRINT consists of 9 interlinked work packages. The distribution and the impacts of PPP on EPAH health will be evaluated at 11 case study sites (CSS), ten located in diverse agricultural European landscapes, and one in Argentina (soy production for feed for EU market). PPP environmental pathways, and direct (food/feed ingestion) and indirect (air/dust inhalation and dermal uptake) animal and human exposure routes will be assessed to improve current fate, exposure, and toxicokinetic models (e.g. EFSA-FOCUS, BROWSE, BREAM). (Eco)toxicological assays will be performed based on CCS findings, using existing and improved procedures, including alternative testing criteria and new target organisms. Such assays will cover direct and indirect exposure to multiple PPP residues, realistic ranges of PPP concentrations, multi-species scenarios, and short- and long-term time horizons. Modelling of sustainability and cost-benefit analysis at the farm and macroeconomic level will be conducted to derive recommendations for sustainable transition pathways, and a research agenda on PPPs. SPRINT is based on a multi-actor approach with CCS platforms to engage stakeholders and identify respective needs, collaboration along relevant WPs, improving farmer and citizen awareness, joint development of novel management strategies for reduced reliance on PPP use, and creation of an enabling environment for adoption and change.
MANUFACTURING AND ASSEMBLY OF MODULAR AND REUSABLE EV BATTERY FOR ENVIRONMENT-FRIENDLY AND LIGHTWEIGHT MOBILITY (MARBEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Italy,Italy,Germany,Spain,Türkiye,Norway,Greece,France,France
Call: Next generation and realisation of battery packs for BEV and PHEV (H2020-LC-BAT-2020, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 11703385.0
EU funding (EUR): 9888796.39
Participants: 16
Project status: SIGNED

With the goal of accelerating the mass market take-up of ultra-high-performance batteries for battery electric vehicles (BEV) and plug-in hybrids (PHEV), MARBEL will base its approaches, solutions and innovations around the versatility concept as an axis within the entire project. It will focus on the need for fast charging and long-lasting batteries to boost end user demands, while applying high modularity and easy assembly and developing novel testing methodologies for safety, profitability and circularity. MARBEL will design, develop and demonstrate new modular, compact, lightweight and high-performance battery packs together with flexible and robust battery management systems for these BEV and PHEV, while maintaining safety levels, allowing fast, high quality and cost-effective large-scale production and following the “made by Ecodesign” principles. A set of modules easy to pack together and to disassemble would ease the manufacture and dismantling of different battery configurations sharing the same production process and common elements. MARBEL will develop and qualify future and innovative performance- and safety- related test procedures of developed functionalities such as the use of miniaturized housings, a flexible test-bench simulating integration-in-EV conditions (electric Vehicle In-the-Loop, eVIL) and artificial intelligence as a tool to reduce the time of laboratory experiments. MARBEL aims at a triple win, for people, business and planet. MARBEL is expected to generate scientific and technological impacts, boost the appearance and consolidation of new players (especially SMEs) and business models, reinforce the European position in the global battery market, and contribute to environmental and societal targets. MARBEL consortium is made of 16 partners from 8 different European countries, representative of the aimed multi-stakeholder collaboration and business drivers required for developing the battery pack of the future.

Keywords: lightweight versatile battery pack,recycled aluminium,easy disassembly,clip,reuse,ecodesign,safetyandperformance tests,smart cell manager,balancing circuit,predictive maintenance
Harmonic Analysis and Differential Equations: New Challenges (HADE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2021-11-30
Duration (months): 72.0
Total project cost (EUR): 1672103.0
EU funding (EUR): 1672103.0
Participants: 2
Project status: CLOSED

This project sets forth cutting-edge challenges in the field of Mathematical Physics that will be solved within a common framework by making novel use of classical tools of Harmonic Analysis such as Oscillatory Integrals and Trigonometric Sums, the Cauchy operator, and the so-called Carleman estimates. Three aspects will be covered: 1.Vortex Filament Equation (VFE) 2.Relativistic and Non-relativistic Critical Electromagnetic Hamiltonians 3.Uncertainty Principles (UPs) and Applications The interaction of vortex filaments is considered a key issue in order to understand turbulence which is seen by many as the most relevant unsolved problem of classical physics. VFE first appeared as an approximation of the dynamics of isolated vortex filaments. I want to understand what happens when at time zero the filament is a regular polygon. Preliminary theoretical arguments together with some numerical experiments suggest that the different corners behave like different vortex filaments that interact with each other in such a way that the dynamics seem chaotic. I will prove the so-called Frisch-Parisi conjecture, showing that behind this chaotic behavior there is an underlying algebraic structure that controls the dynamics. The Dirac equation, despite being one of the basic equations of Mathematical Physics, is very poorly understood from an analytical point of view. I will use the classical Cauchy operator in a modern way to explain some key Hamiltonian systems such as the MIT bag model for quark confinement. UPs are at the heart of different fields like Quantum Mechanics, Harmonic Analysis, and Information Theory. We want to use a new approach to analyze modern versions of UPs that are not well understood. In order to do this, I will look at the problem from the point of view of partial differential equations making novel use of the Carleman estimates. This analysis will also be extended to the discrete setting where even classical UPs such the one by Hardy are not solved yet

Keywords: linear and non linear dispersive equations,uncertainly principle,harmonic analysis
Enforceable Security in the Cloud to Uphold Data Ownership (ESCUDO-CLOUD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Ireland,Spain,Italy,Switzerland,United Kingdom
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 4822750.0
EU funding (EUR): 3827000.0
Participants: 8
Project status: CLOSED

Cloud computing is increasingly a necessary strategical ICT infrastructure component for European companies to successfully compete in the world-wide economy. The advantages of renting ICT infrastructures, platforms, and services, with easy access to scalability and elasticity, are driving an ever accelerating transfer toward the cloud of data and applications. Unfortunately, such a convenience comes at the price of the data owners losing control over their own data and any consequent misuse or security threats on them, which often limit the owner's adoption of the cloud's potential capabilities. On one hand, cloud providers can be assumed to employ basic security mechanisms for protecting data in storage, processing, and communication, devoting resources to ensure security that many medium and small companies may not be able to afford. On the other hand, data owners, when relying on the cloud, lose control over data and their processing, hence leaving them potentially exposed. Today data owners have to choose between having security but limited functionality or fully enjoying functionality but compromising on security and privacy guarantees. This situation has a strong detrimental impact on the adoption and acceptability of cloud services. Data owners may refrain from relying on the cloud for certain data, which they consider more sensitive or critical, or they use the cloud but remain exposed to the consequences of improper protection and control. The goal of ESCUDO is to empower data owners as first class citizens of the cloud. ESCUDO provides effective and deployable solutions allowing data owners to maintain control over their data when relying on Cloud Service Providers (CSPs) for data storage, processing, and management, without sacrificing on functionality. ESCUDO consortium sees the participation of major industry players in the cloud area, and of an innovative SME, contributing real-world use cases, and providing strong exploitation and impact.

Keywords: cloud security,data protection,confidentiality,integrity,availability,efficient access to protected data
Reshaping cortical circuits to decrease binge eating (ReCoDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1499966.0
EU funding (EUR): 1499966.0
Participants: 1
Project status: SIGNED

Obesity and eating disorders are critical problems in society. Many patients with these brain diseases cope with stress by ravenous food intake (binge eating), which engenders new stress and maintains the pathology. Evidence-based treatments for this are urgently needed, but their implementation is hindered by a knowledge gap on: (i) which stress-driven neural disruptions cause binge eating, and (ii) whether these neural circuit changes can be normalized for therapeutic gain. Studies in humans and rodents link binge eating to dysfunction of the prefrontal cortex (PFC), a brain region orchestrating the stress response. However, it is unknown how effects of stress on PFC output cause binge eating. The PFC prominently innervates the lateral hypothalamus (LHA), a region with a crucial role in managing food intake, yet little is known about the function of PFC regulation of the LHA. I predict that stress-induced binge eating requires a functional reorganization of prefrontal cortical control over lateral hypothalamus feeding circuits, and that this control can be restored to limit binge eating. I propose a cutting-edge threefold strategy to address these hypotheses in mouse models: 1. I will unravel the make-up of PFC-LHA circuitry, combining electrophysiology, optogenetics and neural tracing. I will assess how stress functionally alters this complex network. 2. I will determine the concurrent activity at multiple sites within PFC-LHA circuitry as mice engage in stress-driven binge eating, using fiber photometric calcium recordings. 3. I will assess if normalizing stress-altered PFC-LHA synapses rebalances this circuitry in vivo and limits binge eating. For this I will combine optogenetic plasticity protocols, with fiber photometric measurements in freely moving mice. Overall, this challenging project aims to unravel the unclear neurobiology of stress-induced binge eating. If successful, this would provide a key advance in understanding binge eating pathologies.

Keywords: binge eating,stress,synaptic plasticity,prefrontal cortex,lateral hypothalamus,patch clamp electrophysiology,optogenetics,calcium dynamics
PREPARATORY PHASE FOR THE PAN-EUROPEAN RESEARCH INFRASTRUCTURE DANUBIUS–RI “THE INTERNATIONAL CENTRE FOR ADVANCED STUDIES ON RIVER-SEA SYSTEMS (DANUBIUS-PP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Ukraine,Spain,Ireland,Germany,Spain,Austria,Germany,Germany,Italy,Italy,Italy,Estonia,Bulgaria,Greece,Hungary,Moldova, Republic of,Finland,Greece,Romania,France,France,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Preparatory Phase and support to early phase of ESFRI projects (H2020-INFRADEV-2016-2, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 4266405.0
EU funding (EUR): 3996405.0
Participants: 33
Project status: CLOSED

DANUBIUS-PP is a three-year project to raise DANUBIUS-RI (International Centre for Advanced Studies on River-Sea Systems) to the legal, financial and technical maturity required for successful implementation and development. DANUBIUS-RI is a pan-European distributed research infrastructure (RI) building on existing expertise to support interdisciplinary research on river-sea (RS) systems, spanning the environmental, social and economic sciences. It will provide access to a range of RS systems, facilities and expertise, a ‘one-stop shop’ for knowledge exchange, access to harmonised data, and a platform for interdisciplinary research, education and training. DANUBIUS-PP will bring together key stakeholders at different levels, and strengthen the consortium through a process of wide engagement. Individual work packages will refine, inter alia, the scientific and innovation agenda, the legal framework, governance and management, and policies for access and data management. The financial requirements of the RI will be refined to assist funding agencies as they consider future spending priorities. Key deliverables of DANUBIUS-PP include development of the legal and financial agreements for the components of the RI (including Hub, Nodes and Supersites), their governance, and internal organisation which will be confirmed via a Memorandum of Understanding. This preparatory phase project will develop the structures and processes to ensure that the RI strengthens scientific performance by providing a sustainable basis for future operation, delivering key services to the different user communities.
CHEmically-mediated MICRobial Interactions maintained by the toxic dinoflagellate OStreopsis cf. ovata (CHEMICROS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2022-10-31
Duration (months): 36.0
Total project cost (EUR): 275619.84
EU funding (EUR): 275619.84
Participants: 2
Project status: CLOSED

Important proliferation of microalgae, the so-called Harmful Algal Blooms (HABs), affects aquatic ecosystems. Extensive repercussions of HABs on human health, aquatic species, and aquaculture are yearly recorded worldwide and related economic losses can be measured in millions of dollars. Given their impacts, the increasing occurrence of HABs worldwide constitutes a major ecological issue for the coming decades. The proposed research project CHEMICROS (CHEmically-mediated MICRobial Interactions maintained by OStreopsis) aims to investigate the three essential aspects of the microbial control of Ostreopsis blooms: (i) influence on the specialized metabolism, (ii) commitment with toxins degradation, and (iii) potentiality as bio-agents for blooms control. The proposed research will benefit from the training offered by two renowned institutions, the Center for Marine Biotechnology and Biomedicine at Scripps Institution of Oceanography (USA, outgoing phase) and the Laboratory of Oceanography of Villefranche-sur-mer (France, incoming phase), whose research activities focus on natural products chemistry and plankton ecology, respectively. A large part of this project relies on the use of cutting-edge techniques in analytical chemistry, for which I will be trained during the outgoing phase. This knowledge will be transferred to the European host by organizing a technical workshop. The multidisciplinary skillset and knowledge developed through the fellowship will help me gain European and international visibility in the field of microbial ecology and will increase my competitiveness and attractiveness for potential collaborations with researchers in academy or industry, as well as with European managers of aquatic environments. The methodologies developed during the fellowship may be applied to improve our understanding of other HABs species and the dissemination of the results will enable coastal managers to implement preventive measures to safeguard the public.

Keywords: microbial ecology,harmful algae,metabolomics,molecular networking,toxins