Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SPin tExturEs and DYnamics in 3D complex nanostructures (SPEEDY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

Nanoscience is revolutionizing the 21st century in a multitude of areas from nanomedicine to communication technologies, and nanomagnetism is playing a key role in this revolution. The recent move to three dimensional nanomagnetic systems brings with it not only the appearance of novel and unconventional magnetic states but also the realisation of unprecedented properties. In particular, the three-dimensionality is predicted to have a significant influence on the dynamics of magnetic domain walls, soliton-like textures that form the basis of many proposed spintronics devices in recent years. Despite these promising opportunities, most of these exciting new properties remain predictions and have not yet been realised experimentally. SPEEDY aims to establish for the first time an experimental understanding of magnetic domain wall dynamics in systems with a complex 3D structure. We will determine the influence of 3D geometry - by the introduction of curvature and torsion - on the domain wall motion through the study of carefully designed systems with increasing complexity. The project will be conducted in the group of Dr. C. Donnelly at the Max Planck institute for Chemical Physics of Solids, including two secondments of three months in the group of Dr. O. Fruchart in SPINTEC. SPEEDY also constitutes a career development project aimed at enhancing the creative and innovative potential of the applicant, providing excellent working conditions in a high-level highly collaborative research environment. This opportunity will prepare the applicant to become a well-established independent scientist and will be key to building her successful scientific research career in Europe.

Keywords: nanotechnology,3d nanomagnetism,nanofabrication,magnetic microsocopy
The Disobedient Brain: The social neuroscience of non-compliance to immoral orders (DISOBEY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1496688.0
EU funding (EUR): 1496688.0
Participants: 1
Project status: SIGNED

The core goal of this project is to unravel the mechanisms of disobedience. To understand the factors that prevent an individual from complying with immoral orders, research should focus on two critical axes: (1) which social and situational factors support disobedience and (2) which individual traits and neuro-cognitive processes support disobedience. While the first axe has been extensively addressed in past literature, the second axe has scarcely been approached. DISOBEY is uniquely focused on developing a social neuroscience approach to understanding the mechanisms through which resistance to immoral orders may develop in a given situation. Two main neuro-cognitive processes will be considered: the sense of agency that one experiences when performing a voluntary action and the empathic response towards others’ pain. The main hypothesis is that individuals who retain a high sense of agency and empathy for pain under coercion are more likely to resist immoral orders despite potential social costs. To validate this hypothesis, MRI and neuromodulation techniques will be used. The project will include WEIRD (Western, Educated, Industrialized, Rich & Democratic) adults, as well as very unique and rare non-WEIRD populations, such as military, genocide perpetrators, survivors and their offspring in Rwanda, and ‘Righteous’ individuals who rescued lives from extermination during genocides. Including these populations will also allow to validate my hypothesis beyond WEIRD societies, with individuals who actually experienced the disastrous consequences of obedience during real-life events. With this project I aim to pioneer a new area of research that will have deep societal implications. In the future, I intend to develop specific education programs in the future, with the NGOs I am currently working with, for both military members and civilians in vulnerable societies that seek to prevent illegitimate violence on the ground of compliance to authority.

Keywords: disobedience sense of agency empathy for pain social neuroscience behaviors
SCARBO next step - Space CARBon Observatory's solution to improve monitoring of GHG emissions and help establishing reliable data for emission trends forecasts (SCARBOn)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Innovation actions
Countries involved: France,Netherlands,Czechia,Belgium,Germany,Spain
Call: End-to-end Earth observation systems and associated services (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2027-04-30
Duration (months): 40.0
Total project cost (EUR): 3251166.36
EU funding (EUR): 2842833.63
Participants: 11
Project status: SIGNED

SCARBOn (Space CARbon Observatory Next step) is the continuation of the Horizon 2020 SCARBO project. This multidisciplinary project is carried out by a gender-diverse team, through a consortium including the space industry, SMEs and scientific institutes. It is led from Toulouse, France by Airbus Defence and Space. The SCARBOn system is based on a constellation of small greenhouse gases (GHG) monitoring satellites, flying an innovative miniaturised CO2/CH4 instrument (NanoCarb) together with a coregistered compact aerosol sensor (SPEXone). Together, they will deliver twice-daily accurate global measurements to monitor the diurnal variations of fossil CO2 emission. The objective of the SCARBOn project is to mature the technical and industrial definition of the NanoCarb instrument and of the SCARBOn constellation, targeting an operational system availability before the end of the decade. The design of the NanoCarb instrument will be upgraded and refined following the outcomes of the previous SCARBO study, and its performances will be carefully modelled. An instrument breadboard will provide valuable data during an airborne campaign, which will be used together with modelled data to verify the instrument design. This will allow raising the instrument TRL to at least 5, targeting 6 by the end of the project. Data processing at levels L1 to L4 will validate the concept capability to monitor GHG plumes from space. The constellation concept will also be refined in view of a possible short-term industrial implementation. SCARBOn’s daily CO2 and CH4 anthropogenic emissions monitoring data, based on novel European breakthrough technologies, will be a valuable contributor to the European Commission’s endeavour to fight climate change. As an upside, the monitoring data will foster the development of added-value services and will represent a state-of-the-art European alternative to the burgeoning non-European commercial initiatives.

Keywords: carbon,co2,methane,ch4,green house gas,ghg
Natural Auditory SCEnes in Humans and Machines: Establishing the Neural Computations of Everyday Hearing (NASCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Netherlands,France
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 8622811.0
EU funding (EUR): 8622811.0
Participants: 2
Project status: SIGNED

In an office, on a metro, or at home, diverse sounds may be surrounding you: a computer fan, footsteps and indistinct chatter, distant cars, the train slowing down. These sounds shape our environmental awareness, even when visual cues are absent. Despite its ecological relevance, understanding how our brain parses the acoustic scene into semantic objects remains a major scientific challenge. Moreover, individuals with hearing impairments, including those relying on hearing aids or cochlear implants, face challenges, both auditory and cognitive, in environments with multiple sound sources. The NASCE project aims to mechanistically comprehend real-world auditory scene analysis (ASA) through a novel framework: the Semantic Segmentation Hypothesis (SSH). The SSH posits that semantic representations drive real-world ASA, shifting the focus from early acoustic processing to the semantic analysis of everyday sounds. It addresses fundamental questions, such as: How does the brain create semantic sound source representations? How do they interact with acoustic processing, and aid our ability to recognize sounds in a scene? NASCE integrates cognitive psychology, neuroscience, and AI methods. Employing neuroimaging and behavioral paradigms, we aim to reveal how the brain dynamically represents auditory scenes across brain regions for relevant listening tasks. Using deep neural networks and ontologies, we aim to construct neuroscientifically grounded computational models simulating cerebral and behavioral responses under the same scenes and tasks as in the experiments. Finally, with advanced analytical methods we will consolidate behavioral, computational, and neuroscientific insights and establish SSH as a groundbreaking theory of ASA. NASCE promotes a paradigm shift, fundamentally reshaping our comprehension of ecological hearing. Moreover, it paves the way for the applications in machine hearing of computational models that mimic human auditory cognition.

Keywords: natural sounds sound scene soundscape auditory scene analysis acoustics semantics deep neural networks functional magnetic resonance imaging fmri magnetoencephalography meg intracranial electroencephalography ieeg representational similarity analysis rsa connectivity
Computational network-based models of tau progression in Alzheimer’s disease (TauTime)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1437500.0
EU funding (EUR): 1437500.0
Participants: 1
Project status: SIGNED

The aging of the human population has catapulted Alzheimer's disease (AD) from a growing global challenge to an urgent socioeconomic concern. The hallmark of AD is the misfolding and aggregation of proteins β-amyloid (Aβ) and tau in the brain, which can be imaged in living humans using positron emission tomography (PET). Recent clinical trials targeting Aβ have shown promising but modest clinical effects, leading to a shift in focus towards tau due to its closer association with neurodegeneration and cognitive decline. However, tau accumulation is spatially and temporally complex and varies across individuals, complicating its study and therapeutic monitoring. This proposal addresses the need for agile research to enhance our biological understanding of AD while building tools that can aid clinical trials and patient management. I aim to construct TAU-TIME, a computational biology model of tau progression that integrates mechanistic knowledge and individualized data. TAU-TIME will simulate tau accumulation at the individual level and will facilitate testing of biological hypotheses in the context of human AD, where experimental manipulation is challenging. It will also serve as a predictive tool for patient-tailored monitoring, symptom prediction, and enhancing clinical trial power. The proposal encompasses three objectives: 1) optimizing TAU-TIME through integration of spatially-resolved mesoscale human molecular data, 2) leverage individual biological variation at baseline toward patient-tailored models, and 3) benchmark TAU-TIME models on longitudinal tau-PET and cognitive data in a clinical context. These objectives will be achieved through exclusive access to existing data from 2000 patients with extensive neuroimaging and cognitive data, cerebrospinal proteomics, and longitudinal tau-PET measurements over four years. Through these objectives, I aim to enhance understanding of tau pathophysiology, investigate the factors contributing to tau accumulation, and de

Keywords: alzheimer s disease,neuroimaging,multi omics
Energy Efficiency and Electrification Technologies for Heat Flow Optimization in Process Industries (EEETHOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Denmark,Greece,Germany,Spain,Belgium,Finland,Sweden,Italy
Call: Optimisation of thermal energy flows in the process industry (Processes4Planet partnership) (IA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 18409653.48
EU funding (EUR): 14995451.75
Participants: 22
Project status: SIGNED

Industrial process heating accounts for 16 % of total final energy demand and 13 % of the greenhouse gas emissions in the EU. Decarbonizing industrial process heating through electrification and increased energy efficiency is a key measure for reaching the climate targets in 2030, reducing the dependency on fossil fuels, strengthening the exploitation of local renewable energy sources and increasing the competitiveness of the European industry. While there are highly efficient technologies, such as industrial heat pumps, available for temperatures below 150 °C, there is a clear demand for novel technologies for processes with heat demands at higher temperatures. EEETHOS will fill this technology gap by developing key-enabling technologies for energy efficient, flexible and decarbonized process heating, and demonstrating them in five installations at industrial end-users at a TRL of 7. The technologies comprise among others, two high-temperature heat pump solutions for steam supply at up to 200 °C, a reversed Brayton heat pump with supply temperatures up to 300 °C, an innovative technology for heat pump-based drying and heating of minerals, a highly integrated steam compression-based solution for superheated steam drying and a heat capturing device for radiative waste heat recovery. These key-enabling technologies will be demonstrated in 5 demonstrators at industrial end-users representing EUs energy intensive process industries: asphalt, ceramics, pulp & paper, bricks and steel. These technologies are scalable for plant-wide implementation, allow a complete decarbonization at energy savings between 43 % to 86 %, based on local renewable energy sources. The development, implementation, operation and scaling of these technologies is optimized by use of digital twin-based solutions. The project will be a cornerstone for enabling a decarbonized, efficient and competitive European industry, by developing and demonstrating key-enabling technologies at large scale.

Keywords: high temperature heat pumps,superheated steam drying,waste heat recovery,process integration,digital twins,decarbonization,electrification,process heating,energy intensive industries
SUStainable production of High Entropy Alloys from Secondary metals (SUSHEAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Norway,Thailand,Portugal,Türkiye,Sweden
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 775118.57
EU funding (EUR): 736470.0
Participants: 11
Project status: SIGNED

Sustainable Production of High Entropy Alloys from Secondary Metals (SUSHEAS) emerges as a beacon of innovation, targeting the sustainable and efficient production of chemically complex multicomponent High Entropy Alloys (HEAs) through the use of secondary metals. This initiative is set against the backdrop of the current state-of-the-art, where HEA production predominantly relies on virgin materials, which not only contribute to significantly negative environmental impacts but also entail high energy consumption and financial costs. Positioned at the innovation forefront, SUSHEAS introduces a sustainable approach to HEAs production, underpinned by a collaborative framework that unites academic and industrial expertise. Through strategic staff exchanges, the project promotes a dynamic knowledge and skill transfer, enhancing the consortium's innovation and research capabilities. This collaboration accelerates the adoption of eco-friendly HEA production methods and fosters a learning culture. SUSHEAS's focus on AI- driven optimization, alongside techniques for metal recovery, manufacturing, characterization, and prototype demonstration, sets new collaborative research standards in HEA production. By directly tackling environmental, sustainability, and resource efficiency challenges, SUSHEAS demonstrates the power of collaborative innovation in overcoming the complexities of producing HEAs from scraps, marking a significant step towards the advancement of science and technologies in sustainable HEA production. It also highlights the anticipated widespread use of HEAs in future applications that require advanced materials, underlining the importance of defining and popularizing sustainable production methods for HEAs right from the start.

Keywords: high entropy alloys hea,calphad approach,metal waste stream management,materials characterisation,mechanical properties,corrosion and tribo corrosion behavior,prototype design and fabrication
The Holy Grail in Bone regeneration (GreenBone)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3511612.5
EU funding (EUR): 2458128.75
Participants: 1
Project status: CLOSED

Regeneration of large bone defects is an unmet medical need with a high socio-economic burden, affecting millions of people worldwide. To overcome the limitations of existing solutions for bone replacement, we developed GreenBone, our pioneering acellular synthetic bone graft obtained from proprietary biomorphic transformation process of Rattan wood. By mimicking the chemical composition and 3D pore structure of natural human bone, we are able to provide an optimum microenvironment capable of driving inductive bone performance and de-novo bone mineralisation response at the ectopic site. With the EIC accelerator grant first, we aim to disrupt the bone graft market by introducing the first technologically advanced spinal implant that combines the needed mechanical strength with enhanced regenerative capacity. We aim to bring our product to the spinal market segment in 2025, reaching 10% market share in 2030 and growing our company team to more than 40 skilled professionals.

Keywords: bone regeneration,novel materials,biomaterials,biomimetic,bone graft
Inflammatory signals of cell death (FIREALARM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1991250.0
EU funding (EUR): 1991250.0
Participants: 1
Project status: SIGNED

Inflammation is a natural mechanism to restore tissue homeostasis, and its deregulation causes human disease. The programmed cell death form pyroptosis elicits inflammation in a cell-autonomous and non-autonomous fashion by releasing cytokines and ‘danger’ signals. Intriguingly, immune pathology independent of cytokines has alluded to unexplored signaling circuits between cells regulating pyroptotic inflammatory reactions. FIREALARM addresses the fundamental question of the physiological origin of inflammation using convergent system-wide, organismal, cell biological, and molecular approaches. We will test the central hypothesis that endogenous intercellular signaling proteins drive sterile inflammation and shift homeostatic stable to non-resolving chronic states. We will determine paracrine activities of pyroptosis by systematic, iterative ablation of molecule release from dying and perception pathways of sentinel cells. In a complementary approach, we will identify inflammatory signals in vitro and in vivo by newly developed cell type-specific mass spectrometry-based secretomics technologies. Holistic views of intercellular signaling proteins, their exposure, and modification will determine the molecular language orchestrating communication networks between cells and enable the recognition of signals initiating, amplifying, and resolving inflammation. We will achieve a new level of molecular and organismal understanding of intercellular circuits governing homeostasis and conceive strategies to revert chronic conditions. Emerging inflammatory cell death markers will stratify molecular etiology and outcome of patients with sterile inflammatory diseases. Together, FIREALARM tackles the fundamental principles of sterile inflammation relevant for understanding the pathogenesis of chronic metabolic and age-related disorders.

Keywords: cytokines,damps,inflammation,intercellular signaling,cell death,pyroptosis