Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Centre of Excellence for Biomolecular Research (BioExcel)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Sweden,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Centres of Excellence for computing applications (H2020-EINFRA-2015-1, 2015)
Start date: 2015-11-01
End date: 2018-12-31
Duration (months): 38.0
Total project cost (EUR): 4782286.25
EU funding (EUR): 4782286.0
Participants: 11
Project status: CLOSED

Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industrial development. This research has direct influence on our daily life in areas such as health and medical applications, the development of new drugs, efficient drug delivery, biotechnology, environment, agriculture and food industry. Life Science is one of the largest and fastest growing communities in need of high-end computing, and it is a critically important industrial sector for Europe. However, compared to some other disciplines, the use of e-Infrastructure is still relatively new - many advanced techniques are not applied commercially due to limited experience. It requires significant support to: • Make e-Infrastructure useable by researchers who are not computing experts, • Improve the performance and applicability of key life science applications, • Handle large amounts of data in computational workflows. BioExcel proposes to tackle these challenges by establishing a dedicated CoE for Biomolecular Research, covering structural and functional studies of the building blocks of living organisms - proteins, DNA, saccharides, membranes, solvents and small molecules like drug compounds - all areas where with large academic and industrial users bases in Europe. Specifically, BioExcel will • Improve the efficiency and scalability of important software packages for biomolecular research; • Improve the usability of ICT technologies for biomolecular researchers in academia and industry; • Promote best practices and train end users in making good use of both software and e-Infrastructure. • Develop appropriate governance structures and business plans for a sustainable CoE.

Keywords: biomolecular life science,drug discovery,biotechnology,workflows,exascale
FOSTERING WATER-AGRICULTURE RESEARCH AND INNOVATION IN MALTA (FOWARIM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Italy,Malta,Belgium,United Kingdom,United Kingdom
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 960125.0
EU funding (EUR): 960125.0
Participants: 7
Project status: CLOSED

FOWARIM (Fostering Water-Agriculture Research and Innovation in Malta) objective is to strengthen the research capacity of the Malta College of Arts, Science & Technology (MCAST)’s Water Research and Training Centre in 4 crucial themes related to the field of water use in agriculture: (a) Decreasing Water Demand, (b) Making Use of Alternative Sources of Water (c) Renewable Desalinization, On-Farm Desalinization and Utilization of Saline Water and (d) Decreasing Negative Environmental Externalities Caused by Nutrient-Rich Farm Waters. This will be achieved by creating a favourable environment for capacity building targeting Maltese researchers, research institutions networking, research policy development. MCAST will be supported in addressing research deficiencies and networking gaps by EU partners of established scientific excellence in the targeted research topics. The proposal will develop over 3 years and is articulated into 5work packages, including one for management and coordination, involving: capacity building through several targeted and advanced training courses, short-term staff exchanges, summer schools and virtual training; research networking and knowledge sharing through providing technical assistance to establish new demonstration sites to promote innovations and best practices in agricultural water management, (iii) helping foster new collaborations through co-design of research questions, and (iv) developing a joint strategy for high impact research and dissemination; designing a research strategy and performing dissemination and outreach activities. This will lead to strengthening MCAST’s research and S&T capacity in water use in agriculture, enhance the dynamism between the different partners, extending the partnership of research Institutions in the sector in question contribute, to an increase in peer-reviewed publications and complement in more ways than one Malta’s Smart Specialization Strategy.

Keywords: water,agriculture
Fostering DIHs for Embedding Interoperability in Cyber-Physical Systems of European SMEs (DIH4CPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Germany,Spain,Germany,Germany,Spain,Spain,Hungary,Hungary,Poland,Belgium,Hungary,France,France,France,France,France,United Kingdom,Portugal,United Kingdom,Luxembourg,Portugal
Call: Smart Anything Everywhere (H2020-DT-2019-1, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 9158683.75
EU funding (EUR): 7999333.75
Participants: 34
Project status: CLOSED

The initiative for Fostering DIHs for Embedding Interoperability in Cyber-Physical Systems of European SMEs (DIH4CPS) will help European enterprises overcome these innovation hurdles and establish Europe as a world leading innovator of the Fourth Industrial Revolution. DIH4CPS will create an embracing, interdisciplinary network of DIHs and solution providers, focussed on cyber-physical and embedded systems, interweaving knowledge and technologies from different domains, and connecting regional clusters with the pan-European expert pool of DIHs. Backed by the IVLab, an experienced and well-established network organisation focussed on Interoperability, DIH4CPS can innately build on an extensive existing network, add value to its existing knowledge transfer capabilities and guarantee the sustainability of the growing DIH network. DIH4CPS expands the already existing network and aims for creating an integrated platform for DIHs from different, especially digitally underdeveloped sectors and regions. A selection of eleven initially starting application experiments guarantees an outstanding funding for European SMEs and Mid-Caps right from the start and demonstrates the high dedication of the consortium to reduce the digital divide. At least ten additional experiments will take up that torch during the project and allow external companies from sectors in need to further exploit the DIH4CPS network and uplift their portfolio, especially by including (semi)-autonomy into their products and systems. DIH4CPS will not only benefit the application experiments but also the individual DIHs by significantly complementing the regional investments made. Implemented in the IVLab structure, the DIH4CPS Network will leverage and sustain its impact far beyond the project duration, creating a vibrant, overarching and cross sector one-stop-shop for collaboration between SMEs, DIHs and Tech providers.
European Location As A Service Targeting International Commerce (ELAASTIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Germany,Italy,France,Canada
Call: EGNSS applications (H2020-Galileo-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 2484982.0
EU funding (EUR): 1739487.4100000001
Participants: 5
Project status: CLOSED

The success of Galileo will largely depend on its penetration in LBS and M2M markets. While the LBS market is largely dominated by Google and Apple, it is high time to create for the M2M market a comprehensive, EU-based location platform that will bring together all of the location enablers (Galileo, EGNOS, other GNSS, Wi-Fi, Cell-ID), and also win back LBS market shares. Developing applications only, will NOT preserve EGNSS interests, unless first developing the proper location enablers, combining location technologies and taking due account of EGNSS added values. ELAASTIC (European Location As A Service Targeting International Commerce) addresses these needs by developing a European based location service worldwide to ensure EGNOS and Galileo penetration. ELAASTIC will provide: 1. A “Location As A Service” platform focused on delivering reliable location technologies with innovative features based on EGNOS and Galileo signal specificities, 2. An optimized End to End set of location services with full consistency between the Galileo signals, the chipset’s capabilities and additional location infrastructure, 3. Compliance with industry standards for location (e.g. OMA SUPL 2.0), with willingness to contribute to their extension, 4. A service opening for applications developers to rapidly take benefit of Galileo within H2020 first steps, 5. A true commitment to operate a commercial location service as developed during the course of the project, 6. An Ecosystem to ease the deployment of value added services such as eCall and E112. This service will be provided by European (independent of US corporations) companies with a focus on supporting the development of downstream European companies working in the sector. The ELAASTIC proposal has been built through collaboration of five global leaders in location technology: Telespazio France, ST-microelectronics, Thales Alenia Space France, Rx Networks, and Novero, three of them listed as major actors in Berg Insight 2013 LB

Keywords: gnss,assisted gnss,egnos,standards,ecall,e112
Geiger Cybersecurity Counter (GEIGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Israel,Switzerland,Romania,Switzerland,Switzerland,Romania,Switzerland,France,Netherlands,Netherlands,United Kingdom
Call: Digital Security and privacy for citizens and Small and Medium Enterprises and Micro Enterprises (H2020-SU-DS-2019, 2019)
Start date: 2020-06-01
End date: 2022-11-30
Duration (months): 30.0
Total project cost (EUR): 4739716.61
EU funding (EUR): 3999162.5
Participants: 19
Project status: CLOSED

Our proposed GEIGER will be an innovative solution with associated components and an Education Ecosystem addressing security, privacy and data protection risks of and for Small and Medium-sized Enterprises and Microenterprises (SMEs&MEs) in Europe. GEIGER will be developed in analogy of a GEIGER counter for detecting atomic radiation threatening human life. The GEIGER solution will be used for assessing, monitoring, and forecasting risks and reducing these risks by improving the SMEs’&MEs’ security with well-curated tools, and an education program targeting practitioners-in-practice as “Certified Security Defenders” bringing security expertise sustainably to SMEs&MEs using existing vocational education frameworks. GEIGER consist of a GEIGER Indicator that dynamically summarizes the current level of risk by evaluating measures undertaken for security defences among the participating SMEs&MEs. The GEIGER Indicator can be personalised by registering the enterprise’s profile and supports GDPR-compliant sharing and exchanging data about incidents. The GEIGER Toolbox allows stepwise do-it-yourself assessment and improvement of the SMEs’&MEs’ security, privacy, and data protection with lightweight controls and advice for improved protection at varied levels of sophistication. The included tools offer endpoint, server, and network protection and guide the SME&ME in a personalised manner in data hygiene, including access and security control, data privacy management, and backup practices. The GEIGER Education Ecosystem offers experimental-based training and cyber range-enabled challenges and will be integrated into curricula of diverse professions of non-ICT experts, offering direct impact on SMEs&MEs through target group-oriented education. The GEIGER solution will be demonstrated in three complementary use cases within three countries. GEIGER will achieve sustainable impact by raising awareness of more than one million SMEs&MEs within a period of 2.5 years after start.

Keywords: smesandmes,smeandme associations,certs,csirts,reverse mentoring
Nucleotide metabolism crosstalk in cancer: A single cell approach (MetaCross)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2025-12-30
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: SIGNED

DNA synthesis is essential for cell proliferation. Nucleotides, the basic building blocks of nucleic acids, are made by nucleotide de novo synthesis (DNS), and DNS disruption is detrimental to rapidly proliferating cancer cells. Established >70 years ago, anti-nucleotide therapy was one of the first approaches to treat cancer, but it suffers high rate of resistance and relapse. DNS can be bypassed by an uptake of extracellular nucleotides or by recycling in salvage pathways, possibly a reason for limited efficacy of anti-nucleotide therapy. To date, the cellular sources of nucleotides in normal tissue and in tumors in vivo remain poorly characterized. The central goal of this project is to define these nucleotide sources, understand the intercellular metabolic crosstalk of nucleotides in tumors, and characterize the adaptations to DNS blockade in cancer and stromal cells. To reach these goals, I will use the totally new perspective brought by the single cell technology and combine my expertise in single cell omics and metabolism with the state-of-the-art mouse models and advanced bioinformatics available at the host institute. I propose an integrative in vivo approach using single cell RNA-sequencing, which in combination with genetic interventions will allow me to resolve dynamic expression profiles of individual cell types. I will use inducible mouse models to selectively disable DNS in the stroma (lungs of a host animal) and in cancer cells (orthotopic tumors from syngeneic DNS-deficient lung cancer cells) to generate tumors fully relying on nucleotides from internal or external sources, respectively. In parallel, I will perform in vivo CRISPR screen to identify genes whose lack represents a targetable metabolic dependency of DNS-disabled cancer cells. This innovative approach will shed novel insights into organization of tumor metabolic homeostasis and identify new targets with the potential to make major breakthrough in anti-nucleotide intervention in cancer.

Keywords: metabolism,cancer,single cell transcriptomics,nucleotides,de novo synthesis
HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings (HD-Neu-Screen)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In order to overcome the limitations of existing methods for phenotypic drug screening, we propose to develop accurate, label-free, functional neuronal assays for phenotypic/functional drug screening in vitro. These assays will rely on the primary readout of neurons - their electrical signals. We propose to translate and commercialize the assessment of characteristic electrophysiological features of subcellular neuronal components, individual neurons and neuronal networks, all of which can be obtained with high-density microelectrode array technology (HD-MEA), into functional neuronal assays for drug screening. Most of these characteristic features have been developed in the concurrent ERC AdG “neuroXscales”. The model systems for the PoC will include commercially available hiPSC-derived neuronal cell lines. The PoC will be performed in collaboration with the company MaxWell Biosystems AG (http://www.mxwbio.com/), which commercializes multi-well HD-MEA platforms for use in research labs and industry.

Keywords: high density microelectrode arrays,extracellular electrophysiology,human ipsc derived neurons,drug testing,neuronal assays
Body-heat driven Electrochemical pAtch for Continuous dOpamine moNitoring (BEACON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-15
End date: 2023-10-14
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

The following proposal deals with the fabrication and validation of a wearable patch for continuous dopamine sensing, realized using biocompatible materials and additive manufacturing techniques, which would allow to monitor the evolution throughout the day of this hormone which is fundamental in the treatment of many neurological diseases. The candidate wants to provide a simple and non-invasive method which could potentially improve the quality of life of millions of patients and families affected by these diseases and reduce the growing social costs to treat them. The device is thought to be self-powered, using the patients’ body heat as energy source, and works by analysing the dopamine concentration in human sweat, therefore no surgical procedure is required. To detect dopamine concentration, organic electrochemical transistors are used, exploiting their amplification ability to obtain a highly sensitive monitoring device. The patch is also equipped with a radio-frequency antenna for data transmission to medical personnel monitoring real-time the dopamine evolution in the patients. Finally, the patch is designed to be conformable, lightweight and cheap to reduce the patients’ discomfort.

Keywords: conductive polymers,soft electronics,biosensing
Type VI-dependent Pseudomonas aeruginosa phospholipases and host manipulation (T6SS-PSEUDO-LIP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Introduction Pseudomonas aeruginosa (Pa), a nosocomial pathogen, secretes a wide range of virulence factors. A recently described secretion pathway is the type VI secretion system (T6SS). Pa encodes three T6SSs, H1-, H2- and H3-T6SS. The best-characterized H1-T6SS is involved in delivering toxins into bacterial competitors. State-of-the art Two phospholipases (Pld), PldA and PldB secreted via H2- and H3-T6SS, respectively, were recently identified as trans-kingdom virulence effectors, triggering both killing of bacterial competitors and internalization into non-phagocytic cells. They are encoded within two distinct pld clusters that are not present in all Pa isolates. Objectives Our study should (i) decipher the prevalence of the two pld clusters among Pa isolates, (ii) elucidate the role of those Pld during in vivo infection, (iii) confirm the Pld contribution in the T6SS mediated entry, (iv) dissect the PI3K/Akt signalling pathway activation mediated by Pld during Pa entry. Overview of the action The aim is to link the fundamental study of new virulence factors with their relevance into clinical isolates. Methods Pa strains isolated from infection or environment will be screened for the expression of pld clusters. The role of PldA and PldB as virulence factor will be assessed using a murine model of respiratory tract infection. In vitro invasion assays will be performed to validate the role of PldA in the H2-T6SS-dependent entry in non-phagocytic cells. Upstream and downstream signalling events of Akt phosphorylation induced by PldA and PldB upon infection will be dissected by performing cell infections with mutants and specific inhibitors. Originality and innovative aspects of the project Bacteria-host interaction mechanisms are instrumental in the development of infectious diseases. Basic (host laboratory) and clinical (the applicant) research will join to characterize a newly discovered virulence strategy of Pa.

Keywords: virulence,pseudomonas aeruginosa,type 6 secretion system,clinical relevance