Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hyperfine coupled spins with time evolution readout (HYPSTER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2498741.0
EU funding (EUR): 2498741.0
Participants: 1
Project status: SIGNED

Quantum simulation is a promising strategy for understanding the behaviour of quantum systems that are too complex to be calculated directly. HYPSTER will make crucial steps towards creating a quantum simulator from individual magnetic atoms, addressed by means of a scanning tunnelling microscope. I will engineer atomic structures combining electron and nuclear spins – coupled to each other via hyperfine interaction – and read out their collective quantum coherent evolution in real time. The lifetime of any quantum state is limited by its coherence time. While electron spins on a surface suffer from continuous decoherence due to electrons from the substrate, nuclear spins are much better isolated, holding potential for orders of magnitude longer coherence times. By providing controlled access to the real-time dynamics of the nuclear spin, HYPSTER aims to unlock this invaluable potential. First, expanding upon a unique measurement procedure developed in my group, I will trace the combined time evolution of a nuclear spin coupled to an electron spin, allowing quantum information to be exchanged between the two. Next, I will explore methods to controllably couple and decouple the nuclear and electron spins by rapidly adjusting the local Hamiltonian. This will allow the nuclear spin to evolve by itself, not hindered by external decoherence sources. Finally, I will employ dual-frequency electron spin resonance to enable remote detection of spin dynamics, constructing a pathway towards connecting multiple nuclear spins over a distance. The objectives of HYPSTER will provide a toolset that can be readily adopted throughout the blooming field of on-surface spin systems and set the stage for true atomic-scale quantum simulation.

Keywords: stm,esr stm
Exposing the glial metabolism - common link to brain damage (LipidGlia)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

European population is rapidly aging. While it was commonly believed that brain aging leads to neuronal loss, recent studies found that instead the volume of white matter (WM) decreases and WM lesions develop with age. WM degeneration is also a hallmark of multiple neurological disorders including Alzheimer’s disease or multiple sclerosis. Understanding cellular responses to WM injury is therefore critical for design of regenerative therapies of central nervous system (CNS). The European population is also increasingly overweight. Obesity is associated with higher risk of multiple sclerosis and other neurological diseases and leads to systemic low-grade inflammation modulating functions of the immune cells. While this paradigm has been extensively studied in peripheral tissues, effect of diet on microglial states in CNS is poorly understood. I hypothesise that high-fat diet disrupts metabolic response of microglia to WM injury and impairs regeneration. My proposal aims to identify diet-altered microglial pathways and how to target them for promoting recovery after injury. For this goal, I will use the single cell and spatial transcriptomics to characterize in detail how WM injury and obesity alters cellular phenotypes. However, currently no method can link the metabolic state of the cell with its transcriptome. I will establish method that combines metabolic measurements with single cell RNA-Seq in mouse models of high-fat diet and demyelination. In addition, I propose to integrate spatial transcriptomics with electron microscopy as an innovative approach to visualize lipid-loaded microglia and link their morphology to the transcriptomic state. This project will provide critical new knowledge of mechanisms of WM repair. The fellowship will allow me to become expert in applying and developing genomic technologies to devastating neurological disorders, and deepen leadership and management skills to achieve my career goal of becoming independent investigator.

Keywords: microglia,genomics,white matter,myelin,metabolism,lipid droplet,obesity,rna seq,multiple sclerosis,spatial transcriptomics,electron microscopy,cholesterol,neuroinflammation
Hydrogen Bond Networks as Optical Probes (HyBOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1523488.0
EU funding (EUR): 1523488.0
Participants: 1
Project status: SIGNED

Fluorescence takes place throughout the natural world. Most conventional chemical wisdom proposes that in organic entities, fluorescence occurs in conjugated systems, such as in the aromatics. However, in biological settings, the interaction of light with matter occurs in media built up of dense networks of hydrogen bonds. Recent experiments suggest that it is possible to observe fluorescence from these networks too. This could open the possibility of designing hydrogen-bond networks with enhanced fluorescence, offering enormous fundamental and practical potential. The overarching goal of HyBOP is to decipher, using advanced computer simulations, the exotic optical properties of hydrogen-bond networks and to harness them as probes of water-mediated forces. To achieve this, HyBOP will tackle the following challenges:1) Establish the ground rules for creating fluorescent hydrogen-bond networks in biological materials. 2) Understand how to drive the electrons and nuclei of water networks into regimes where they can fluoresce. 3) Use the optical behaviour of these networks to probe hydrophobic forces in nature. To uncover the complex chemistry of hydrogen-bond network fluorescence, and guide the discovery of new fluorophores, we will deploy state of the art electronic excited-state molecular dynamics in combination with machine-learning techniques. This will provide HyBOP with ground-breaking knowledge which will lay a theoretical framework to motivate development of new experimental probes of hydrophobicity. HyBOP seeks to bring hydrogen-bond networks to the forefront of chemistry in their use as optical probes; by laying the theoretical ground-work for designing non-invasive fluorophores in biophysics, opening up a new window into the origins of autofluorescence in medical diagnostics and finally, provoking frontier electron and nuclear spectroscopy, HyBOP will have a spill-over effect and build new synergies across several branches of the physical sciences.

Keywords: fluorescence,aqueous systems,data science
Investigating Methane for Climate Action (IM4CA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Netherlands,Poland,Belgium,France,Cyprus,United Kingdom,Greece,Germany,Austria,Romania,Norway,Sweden,Switzerland,Finland
Call: Enhanced quantification and understanding of natural and anthropogenic methane emissions and sinks (HORIZON-CL5-2024-D1-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 14738820.0
EU funding (EUR): 14738820.0
Participants: 25
Project status: SIGNED

The IM4CA proposal unites leading European methane experts in a concerted effort to establish the scientific fundament needed to bring the climate forcing of methane under control. Specific objectives are to: 1) Strengthen methane mitigation policy world-wide with actionable information on local methane emissions and key driving processes, 2) Provide the EU with the measurement and modeling capacity needed to monitor its methane emissions and assess its progress towards the 30% emission reduction target of the European methane strategy and the global methane pledge, 3) Explore and understand climate feedbacks on natural methane sources and sinks, and 4) Improve the accuracy of climate scenarios by resolving the controversy about the causes for the recent growth rate variations in global methane. To achieve these objectives we address a selection of key uncertainties that have thus far limited the progress towards these goals by: i) building up critical new infrastructure for monitoring methane emissions in Europe and Tropical Africa, ii) developing methodology for efficient use of existing and upcoming satellites for measuring methane and the land surface properties needed for characterizing and attributing its emissions, and iii) translating the knowledge obtained into reliable projections of future methane and efficient emission mitigation scenarios. In doing so, the IM4CA project will enable a breakthrough in meeting the work program challenge of enhancing the quantification and understanding of natural and anthropogenic methane emissions and sinks. It will provide enhanced European assessment capacity of short- and long-term changes in methane sources and sinks integrating information from multi platforms and novel observations and transfer that capacity into actionable information needed to combat climate change.

Keywords: global warming,climate forcing,methane,hindcasting,emission verification,climate mitigation,future scenarios
AgrifoodTECH: Seeding a brighter future for EU key sectors. (AgrifoodTECH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Italy,Netherlands,Greece,Romania,Portugal,Ireland
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1528320.0
EU funding (EUR): 1528320.0
Participants: 17
Project status: SUSPENDED

The EU is the world's largest food producer, but climate change, loss of biodiversity and scarcity of resources, among others, put food security at risk. It is necessary to boost and promote technologies in the agri-food sector that lead to a more sustainable production model adapted to climate change and thus reduce dependence on imports in an unstable geopolitical scenario. The AgrifoodTECH program, led by the Polytechnic University of Cartagena (UPCT), is designed to equip 16 postdoctoral researchers with the skills necessary to lead advancements in the agri-food technology sector, central to the Agriculture 4.0 revolution. This interdisciplinary training program encompasses 10 crucial knowledge areas addressing future agricultural challenges and integrates international and intersectoral experiences through collaborations with 14 associated entities for secondments. UPCT is a member of the European University of Technology (EUt+) and has been recognised by the EC HRS4R distinction for its positive and stimulating environment for researchers. UPCT is located in the Region of Murcia (Spain), where the agri-food sector is considered strategic and its digital transformation a priority in its RIS4Mur. AgrifoodTECH is poised to establish a pioneering postdoctoral program recognized internationally for its research excellence. This initiative aims to position both the University and the Region of Murcia at the forefront of agricultural innovation in the 21st century. Furthermore, it seeks to lay the groundwork for founding the first European Research Institute (ERI) dedicated to agri-food technology, spearheaded by UPCT. This endeavor will be bolstered by the contributions of postdocs trained under the AgrifoodTECH banner, ensuring a strong foundation for groundbreaking research and development in the sector.

Keywords: agri food technology,agriculture 4 0,sustainability,european research institute,interdisciplinary,smart agri food,food security
Waves in the Inner Magnetosphere and their Effects on Radiation Belt Electrons (WIRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999415.0
EU funding (EUR): 1999415.0
Participants: 1
Project status: SIGNED

The magnetosphere is a natural plasma laboratory. Radiation belts in the magnetosphere are full of high energy particles. The energetic electrons in the Earth’s radiation belts can be hazardous to Earth-orbiting satellites and astronauts in space. Many of the space systems on which modern human society depends operate in this region. The fluxes of radiation belt electrons are very dynamic, which is not fully understood due to the delicate balance between various acceleration and loss processes. Wave-particle interactions are believed to play a crucial role in the acceleration and loss of these particles. To quantify the effect of different waves on the dynamics of radiation belt electrons, comprehensive wave models are needed. Currently, there are some wave models based on satellite measurements. However, the space coverage of these wave models is not sufficient due to the orbit limit of satellites. In this project, combining state-of-the-art measurements from multiple satellites, comprehensive wave models will be developed. We will improve our sophisticated physics-based radiation belt dynamic model by using the wave models developed in this project and calculate diffusion coefficients using more realistic background magnetic field and plasma density models for the first time. Furthermore, fundamental acceleration and loss of energetic electrons caused by different waves in the Earth's radiation belts will be quantified. We will systematically validate simulation results against satellite measurements to understand the competition between acceleration and loss caused by various mechanisms. All these improvements will be critically important for answering the overarching scientific question: Why do the Earth’s radiation belts respond differently to geomagnetic storms which have approximately the same intensity? The knowledge gained in this project can be useful for basics plasma physics and astronomy physics because the similar fundamental processes exist.

Keywords: earth s radiation belts,plasma waves,wave models,wave particle interactions,radiation belt modeling
Improving Access to Services for Victims of Domestic Violence by Accelerating Change in Frontline Responder Organisations (IMPROVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Germany,France,Austria,Finland,Hungary,Spain,Portugal
Call: Domestic and sexual violence are prevented and combated (HORIZON-CL3-2021-FCT-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3185790.0
EU funding (EUR): 2978095.5
Participants: 16
Project status: SIGNED

In combatting domestic violence progress has been made, however policy implementation remains slow and domestic violence mostly remains under-reported by the victims and under-detected by the frontline agencies. IMPROVE project develops several tools to increase reporting and detection of domestic violence by empowering the victims to understand their rights for services and justice, and by supporting Police Authorities, Civil Society Organizations and other frontline responder organisations to enhance their competencies to utilize innovative solutions that enable and accelerate policy implementation. IMPROVE will develop Conversational (multilingual) AI Chatbot (AINO) that provides the victims immediate advice and risk assessment as well as guidance towards the available service provisions. The performance of AI Chatbot will be consistently improved by machine learning using inputs from the victim-survivors. IMPROVE will support the planning and decision making of policy makers and managers to fully utilize innovative solutions in the priority areas in order to accelerate policy implementation and enhance positive operational outcomes through effective application of tools, procedures and measures to combat domestic violence. IMPROVE will address frontline responders training needs by designing training materials covering sector specific and cross-sector contents supported by innovative teaching and learning methods. IMPROVE will construct and deliver targeted awareness campaigns for the victims, their social environs, and community representatives as well as frontline responder practitioners, managers, policy makers and academic experts. Innovations produced by IMPROVE are based on applied research that constructs a pioneering conceptual approach that is able to address diverse identities of the victims, the under-served, vulnerable and marginalized individuals and multiple forms and situations of domestic violence.

Keywords: domestic abuse violence frontline responder services multicultural lingual european regulatory framework harmonization impact of crises social innovation theory of change sustainable impact,
Digital Twins Enabled Indoor Air Quality Management for Healthy Living (TwinAIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Greece,Portugal,Sweden,Ireland,Germany,Spain,Netherlands,Cyprus,Belgium,United Kingdom
Call: Indoor air quality and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 6925584.7
EU funding (EUR): 6925582.0
Participants: 24
Project status: SIGNED

TwinAIR aims to improve urban life by tackling the challenge of indoor air quality (IAQ) improvement by understating its complex interrelationship with external factors. This is achieved by introducing a novel set of tools for identifying sources and tracing a variety of pollutants and pathogens, for enhancing understanding of their effects and assessing their impact on health, for controlling building management systems and services in ways that mitigate part of the impacts and for helping citizens to develop better insights into pollution impacts, along with encouraging healthier, more sustainable choices. TwinAIR embraces bleeding edge innovation in urban sensing (chemical and environmental sensors), data analytics and visualisation (digital maps and real-time video analysis), smart buildings (digital twins and virtual sensors) and behavioural insights (citizen participation, gamification) to deliver a nascent solution. It is implemented across six diverse pilot sites in Europe (ES, IE, UK, SE, DE, EL) with demonstrations covering residential dwellings, public administration buildings, hospitals and schools, along with selected types of vehicles (buses, vans). TwinAIR?s toolsets will empower students and their parents, commuters, workers and residents to make more health-aware personal decisions about their everyday mobility options and use of indoor spaces, through access to insightful analytics and engaging visualisations of their data, as well as by their participation in educational events and activities. At the same time, it will provide rich evidence to transport planners, facility managers and policymakers about factors influencing IAQ and effective interventions for mitigating its effects on health and wellbeing. By democratising cutting edge innovation in sensors, digital twinning and visual analytics, TwinAIR will enable better decision-making about future mobility policies, built environment management and incentivisation of citizens. Project TwinAIR is part of the European cluster on indoor air quality and health.

Keywords: indoor air quality,health impact assessment,exposure analysis,iaq monitoring and control,digital twins,virtual sensoring,citizen science,social engagement