Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain Cancer Therapy Monitoring using a Novel Quantitative and Rapid Magnetic Resonance Imaging-based Method (OncoViroMRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 269998.08
EU funding (EUR): 269998.08
Participants: 3
Project status: CLOSED

Glioblastoma multiforme (GBM) is the most common type of brain tumor found in adults and is fatal in all cases. A very promising therapeutic approach for GBM is the use of oncolytic viruses (OVs) that selectively infect, replicate in, and destroy tumor cells, while sparing the surrounding normal cells. Nevertheless, to achieve successful oncolytic virotherapy, frequent non-invasive monitoring of the process must be performed. This is crucial for gaining a better understanding of the interactions between the virus and its tumor-host and predicting a therapeutic response. Thus, the development of a non-invasive method, capable of accurately quantifying the location and extent of the viral spread in the tumor is highly required and is of great importance. Accordingly, the main research goal of this action is to develop a magnetic resonance imaging (MRI)- based method for accurate, quantitative, and rapid imaging of OVs delivery, and spread in clinically relevant tumor models. The devised interdisciplinary methodology includes: genetically modifying the therapeutic virus to be detectable in MRI; developing machine learning methods to increase the speed, specificity, and sensitivity in image-monitoring the virus; and evaluating the established methods using mice models of brain tumor therapy. The allocated training and research environment is optimal for achieving the proposal goals: an outgoing phase at Harvard Medical School, a secondment at a leading clinical MRI company (Insightec), enhancing translation potential, and a return phase at a leading university (Technion), ensuring the transport of knowledge back to the EU. The envisioned technology could be expanded to various additional clinical conditions, and its dissemination could improve patient care. The unique skill set to be acquired by the experienced researcher, would allow claiming a distinct niche of knowledge, increasing competency to a tenure-track position, and a research career in the EU.

Keywords: cancer therapy image monitoring,oncolytic virotherapy,biomedical engineering,algorithm development,chemical exchange saturation transfer cest mri,mice imaging,clinical translation
Flexible x-ray detectors for large area imagers: towards consumer electronics (FLE-X)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-04-01
End date: 2022-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Techniques for non-destructive and non-invasive inspections are more and more required in our society, in different areas such as medical, industrial and security. X-ray radiation and its detection is the current inspection tool, coupled with electronic systems to gather information. However, while the electronic has gone through an impressive development to respond more and more to the need of a capillary presence in our life, without disturbing perception, the X-ray detection has remained behind. Thus, Users are limited to costly, cumbersome, fragile and extremely heavy detection devices, which do not allow nor extension to large areas neither easy integrability/conformability to a large variety of objects. FLE-X will develop the prototype of a low cost, flexible direct x-ray detector for imaging applications, which can be customized. It will be suitable for large areas inspections, and bendable around complex objects. It will be easy to handle. This will be achieved by developing printed thin films (<< 100 um) fabricated from lead-halides perovskites inks. Such device does not exist on the market. Once transformed into a commercial product, it will enable a shift paradigm for the X-ray detection market and will be a gate for new applications. To make this happen, FLE-X will identify the first process flow compatible with industrialization, will deliver a prototype of flexible X-ray imager and will provide a model and business plan which will allow an efficient technology transfer.

Keywords: x ray detector,perovskites,flexible electronics
Transposon-activated Genome-wide search for novel Nociceptors (TransGeNo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-20
End date: 2022-04-19
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The perception of pain is crucial for our survival, enabling avoidance of harmful physical and chemical insults. Pain initiates in primary sensory neurons, which are highly variable cells innervating the skin, mucus membranes and internal organs. These neurons express combinations of receptor molecules decoding adverse mechanical, thermal and chemical stimuli. Receptor molecules sensitive to these cues decode such inputs into action potentials, which are then relayed to the central nervous system. Uncovering the identity and regulation of these sensory receptor molecules has long been of high interest to the neuroscience community. Being the first point of possible intervention in the signalling process that leads to the perception of pain, therapeutics designed to target these molecules have high promise. Many such receptors have been identified in the past decades. The thermo- and chemosensory TRP channels, intricately involved in our perception of inflammatory pain and injury-induced hypersensitivity, are at the focus of intensive investigations. The recently identified Piezo proteins have significantly advanced our understanding of how sensory nerves decode light touch and proprioception. Many receptors in this system, however, remain to be identified. Among them are mechanoreceptors of painful tactile stimuli, as well as those responsible for the tingling, numbing sensation induced by alkaloids found in Sichuan peppers. Identifying these would open new areas of pain research and provide new, promising targets for analgesic therapy. Here I will employ a new method, Transposon-Activated Genome-wide Screening (TAGS), to identify these receptors. Inspired by the process of evolution, TAGS creates random genetic mutations in vast cell populations and enlists the law of large numbers to identify the role of individual genes. In the long-term, I will broaden the scope of TAGS to enable gene discovery across multiple disciplines in biomedical sciences.

Keywords: transposon,random activation mutagenesis,genome wide screening,mechanotransduction,chemosensation,somatosensation
Developing on line tools to monitor, control and mitigate GHG emissions in WWTPs (C-FOOT-CTRL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Australia,Germany,Greece,Greece,United States,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 711000.0
EU funding (EUR): 711000.0
Participants: 10
Project status: CLOSED

C-FOOT-CTRL aims to develop, test and validate a new software tool for the online monitoring, control and mitigation of the carbon footprint of wastewater treatment plants (WWTPs). Gaseous emissions are emitted from various stages of treatment in a WWTP. Currently, in developed countries the energy required for wastewater treatment accounts for approximately 3% of the total electrical load. Also, WWTPs are the biggest single energy consumers of municipalities with a share of 20% of the total energy consumption. The typical energy efficiency of WWTPs in Europe is less than 50%, when energy efficiency is defined as the ratio of electricity generated at WWTP to the electricity needed from grid to operate the WWTP. Strategies to decrease the required amount of energy may in fact cause greater harm due to the increase of GHG emissions. Various greenhouse gas emissions are associated with the construction and operation of WWTPs. These include carbon dioxide, methane, nitrous oxide, with nitrous oxide being 298 times more harmful than CO2. The development of a tool that will be able to accurately record on line the various gaseous emissions during the construction and in the different treatment processes of WWTPs is important in order to (i) track the emissions at the moment of occurrence (ii) immediately apply measures to reduce gaseous contaminants and to (iii) link the gaseous emission with a particular activity in the plant. The on line GHG emissions monitoring and control system will be an innovative, low cost and flexible system based on wireless sensor networks for monitoring and ‘supervising’ activities aiming to reduce GHG emissions during the operation of WWTPs at all stages (pre-treatment, primary treatment, biological treatment, tertiary treatment).

Keywords: wastewater treatment,carbon footprint,greenhouse gas emissions
Advanced monitoring, simulation and control of tidal devices in unsteady, highly turbulent realistic tide environments (RealTide)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Belgium,France,France,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2018-01-01
End date: 2021-09-30
Duration (months): 45.0
Total project cost (EUR): 4974990.02
EU funding (EUR): 4974990.02
Participants: 9
Project status: CLOSED

Recent advances in the measurement of flow in highly energetic tidal currents allows the effects of both turbulence and ocean waves to be characterised. This provides improved understanding of the causes of failure in tidal devices, including blades, seals, bearings, PTO & other critical components. Combining this new understanding with state-of-the-art condition monitoring systems will allow fault-tolerant, resilient, components to be designed. The project will combine innovation in flow measurement, condition monitoring and turbine components with tide-to-wire modelling to design reliable power take off & control systems delivering grid compliant energy. This is only possible by the inclusion of partners with: (1.) a proven track record of high resolution flow measurements in the highly energetic waters of the EMEC tidal site, (2.) access to open- sea pilot test site and turbine data, (3.) world leading capabilities in testing of materials for the marine environment, in design, construction, installation and operation of tidal devices, condition monitoring / condition- based maintenance, world leading tank test facilities, and a detailed understanding of technology verification & certification in offshore energy. Machines using the outputs of the project will be a key part of new bankable projects to deliver electricity at a highly competitive LCE. Through the design of reliable intelligent blades and components with integrated condition monitoring, for the first time, provide [...know how...] for Real Turbines, operating in Real Seas and under Real Conditions.

Keywords: ocean energy,marine renewable energy,tidal turbines,reliability,turbulence,condition based maintenance
Eye-Free user interface to give full access to smart devices for blind and visually impaired people (BlindTouch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today, only a fraction of the 285 million visually impaired people around the world can effectively use smartphones and connected digital services. Despite the efforts of developers and organisations promoting accessibility, blind people are painfully behind when it comes to smartphone technologies, which all use graphic UIs and touch-screens, & are expensive and entirely sight dependant leaving them using outdated, basic devices. For them, smartphones have widened the divide between them and the seeing. A new solution is needed to bridge this gap. Project Ray have developed BlindTouch, a smartphone UI that is automatically imposed across all system functions, applications and services. All features can be easily accessed due to the multiple input options enabling the visually impaired simple operation of their digital devices. In this way BT allows the blind and visually impaired community to effectively use smartphones as part of their daily lives, bringing benefits of smartphone technology into their hands. BT provides advanced services allowing users become a contributing member of society, without a reliance on care assistants and guide dogs. It is the only smartphone solution for the visually impaired that gives them access to the connected world at an extremely reduced price. Following a promising Israeli pilot trial that led to paying subscribers for our prototype system, Ray intend to fully commercialize the solution by reaching the market in 2021. Incorporated in Israel in 2013 with €1.15M in funding and a staff headcount of 12. The proposed work in Phase 1 of the SME instrument fits into the overall Project Ray plan to reach market by contributing the financial resources needed to plan a fast, sound and wider deployment of the solution and the market uptake. It will also allow the SME to accomplish key feasibility activities and reduce the business risks, such as business planning, customer identification and outreach, and stronger IP management strategy.

Keywords: user interface,smartphone,visually impaired,blind
VEhicles as High-status Indicators in the CUlture of Late Antiquity (VEHICULA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

VEHICULA is a study of vehicles as means for elite self-representation and the visualization of social hierarchies in the late Roman empire: its aim is to produce a comprehensive study of cultural history, which will be of interest to those in all fields of classics and history. In late antiquity, the increasing hierarchisation of society was matched by a need for the visualization of its structure: every citizen was bound not only to occupy his or her own place in society, but also to exhibit the distinguishing features of his or her rank, in a way that could be immediately clear to every viewer. Vehicles were among the most impressive signs of social and economic power; but they are also one of the most underestimated by modern scholars. The use of elaborate vehicles was the principal means for elite self-representation in public spaces, where the prestige and power of a nobleman was made clear by the lavish parade by which he was surrounded while moving through the city. The project will address several categories of visual and written sources, combining the competences and methods of archaeology, art history, classical philology, and literary criticism, and exploiting their results through the lenses of social history and the history of ideas. The innovative focus on vehicles will help clarify some characteristic developments of late antique culture and society in different contexts in which vehicles played a key role, including: the evolution of pagan theology and rituals; the establishment of a bureaucratic structure for central and territorial administration; the construction of gender identity among the elites; the competing modes of elite self-representation (senatorial, military, ecclesiastical) in the public and private sphere; the establishment of the Christian Church as a new centre of power alongside and competing with the traditional ones; the survival of Roman institutions and their insignia in the transition from antiquity to the middle ages.

Keywords: late antiquity,elite self representation,social history,roman empire,rituals and ceremonies
Secure, reliable machine learning based technology platform for the creation and authentication of Digital Identities to enable safe digital transactions across Europe (Daego)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fraud due to Digital ID (Identity) thefts is a huge economical and security problem for organizations. As a token, in 2018 American companies lost $3.4 billion in new accounts fraud. Furthermore, Digital ID fraud undermines digital engagement as users do not trust their Digital ID security. A secured system of Digital ID Verification is mandatory to drive digital growth. However, while Digital users demand better security, they are frustrated by the current Digital ID verification methods. 43% of digital users think that Digital ID verification solutions are cumbersome and are saying NO to current procedures to verify their Digital ID. The challenge is to build a secure, fully automated and user-friendly Digital ID verification for customer on-boarding. PXL Vision AG has developed a proven solution is Daego, a modular, user-centric, fully automated, scalable and secure software platform that best optimizes company resources and UX for customer on-boarding. Based on unique technical features that go beyond state-of-the-art, the deployment of DAEGO has huge benefits for users: 100% reduction of fraud; >75% reduction in customers on-boarding cost; BIG increase in customer digital engagement; as little as one week for deployment; low implementation risks proven in leading industrial verticals. The business opportunity is huge: the Digital ID Verification market size is expected to grow from $6.0 billion in 2019 to $ 12.8 billion by 2024, at a CAGR of 16.0%. Market drivers are the rising number of identity frauds, stronger regulations on general data protection, enterprise mobility and BYOD (bring-your-on- device) trend. Created for entrepreneurs with strong technical and business experience, PXL Vision has become in two years in the market, a reference for Digital ID verification in Switzerland, with a filed patent with more than 40 claims, backed-up by key investors and winner of the most prestigious Swiss entrepreneurial awards in 2019.

Keywords: digital identity,document verification,identity verification,facial recognition,process automation,machine learning,liveness check
Preventing and Addressing Violent Extremism through Community Resilience in the Balkans and MENA (PAVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Iraq,Germany,Germany,Finland,Bosnia and Herzegovina,Tunisia,Sweden,Greece,France,Lebanon,Kosovo
Call: Drivers and contexts of violent extremism in the broader MENA region and the Balkans (H2020-SC6-GOVERNANCE-2019, 2019)
Start date: 2020-02-01
End date: 2023-04-30
Duration (months): 39.0
Total project cost (EUR): 2999651.25
EU funding (EUR): 2999651.25
Participants: 13
Project status: SIGNED

Based on an interdisciplinary, participatory and inter-regional approach, the main objectives of PAVE are (1) to advance evidence-based knowledge on violent extremism in the MENA and the Western Balkans beyond the state-of-the-art, and (2) to strengthen the capacity of policy-makers and community leaders and support multi-stakeholder exchange for an effective prevention of violent extremism between the European Union and its neighbourhood. To achieve these objectives PAVE will conduct comprehensive analysis on the drivers and contexts of violent extremism at the interface between religion, politics and identity, with a specific focus on factors of community vulnerability to ideological and behavioural patterns of radicalisation. PAVE will also assess the relevance and effectiveness of preventive initiatives against violent extremism, with a specific focus on measures to enhance community resilience. The four thematic areas of investigation are: 1) interface between religious, political and ethnic/sectarian extremisms, (2) interaction between religious and state institutions, (3) on- and offline narratives and (de-)radicalisation, and (4) transnational interactions, including impact on and from Europe. The empirical enquiry will encompass in-depth case study research in selected municipalities in four Balkan countries (Bosnia and Herzegovina, Kosovo, Macedonia and Bosnia) and three MENA countries (Tunisia, Lebanon, Iraq); intra-regional comparative analysis; and cross-regional comparative especially talking into consideration effects on European Security. PAVE will also develop innovative training tools and guidelines to support agents of community resilience (including religious leaders, mayors, educators, civil society organisations, women and youth), and will support mutual learning on best practices and increase awareness on drivers and contexts by engaging stakeholders, community leaders, policy-makers and wider public in the EU, MENA and Balkans.

Keywords: mena,balkans,violent,extremism,radicalism,religious,interethnic,identity,vulnerability,resilience,ideology,narrative,transnational,multi stakeholder,community,prevention,training