Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Super-resolution Field-Resolved Stimulated Raman Microscopy (Beyond the visible)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: SIGNED

The next generation of biological imaging will be a movement towards super-resolution, label-free approaches to visualize subcellular structures in a nonperturbative, non-invasive manner. In this proposal, a super-resolution, label-free, Raman microscope based on a novel, ambient-air, field-detector is envisioned to fulfil the requirements of these exciting prospects, essential for biomedical advancements. By employing bright, ultra-broadband, femtosecond electromagnetic forces at petahertz frequencies, Raman molecular vibrations are driven coherently and efficiently. Temporal confinement of the excitation pulses to a few femtoseconds allows for temporal filtering of the molecular response and therefore, a high signal-to-noise ratio, and high detection sensitivity is achieved. The same laser provides optical pulses with ultrashort duration to directly access and detects the field oscillations of the emitted Raman molecular response. This novel detection metrology allows for simultaneous and broadband detection of the entire molecular fingerprint and beyond with high dynamic range and sensitivity down to quantum shot noise. Most importantly, due to the near-field imaging in this scheme super-resolution, chemically sensitive images can be constructed without the need for labeling molecules or using structured light. The advanced near-infrared femtosecond source in combination with the novel field detection technology will enable acquiring the complete fingerprint of complex biological molecules non-invasively with a spatial resolution and sensitivity exceeding that of any previously demonstrated method, for the first time. The next generation of laser-driven biological microscopy requires a dramatic leap in sensitivity, dynamic range, spatial resolution, and non-invasiveness; this proposal represents a coherent, achievable approach to fulfilling this need opening up new horizons for fundamental studies in science to see beyond the visible.

Keywords: stimulated raman microscopy,super resolution label free imaging,sensitive field resolved spectroscopy,petahertz field detection
Retrieving novel TEXtile solutions from MArine and TERrestrial biomass (TexMaTer)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Portugal,France,Switzerland,Finland,Italy,Faroe Islands
Call: Novel, sustainable and circular bio-based textiles (HORIZON-CL6-2023-CIRCBIO-02, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 6062843.09
EU funding (EUR): 4873448.97
Participants: 16
Project status: SIGNED

TexMaTer aims at producing novel cellulosic fibres and bioformulations for textiles’ finishing using under-utilised biomass resources and wastes from agricultural practices and micro- and macroalgal production (typically rich in cellulose and other bioactive compounds) and post-consumer home textiles (as an extra source of cellulose). These functional and sustainable solutions will be further used in prototypes for fashion and home textiles’ markets. The project covers all steps required to produce novel cellulosic fibres and functional textiles for the envisaged markets: from the obtention and transformation of raw materials for application in textile production processes, to fibres/yarns production and bioformulations development (at laboratory, pilot and industrial scales), ending with eco-design and prototypes manufacture. To ensure recyclability and circularity of the developed solutions, and an efficient uptake of the products by the consumer, the development of TexMaTer products will be designed considering promising End-of-Life (EoL) alternatives and also functionality, safety, environmental sustainability and social and economic benefits for consumers. Consumer behaviour studies and raising-awareness actions are also planned, thus contributing to increase consumers’ acceptance for the developed products. By incorporating bio-based resources and promoting the upcycling of post-consumer textiles, TexMaTer will increase the competitiveness of the textile & clothing industry (T&CI), significantly reducing the negative environmental impacts commonly associated to this sector: 1) the intensive use of synthetic fibres, virgin cotton and wood-based cellulose (whose production is responsible for high CO2 emissions, water consumption and contamination, and inappropriate forest management, respectively); and 2) the overutilisation of synthetic dyes and chemicals in textile finishing processes (which are typically rejected in textile wastewaters and recalcitrant).

Keywords: algae,agricultural waste,post consumer textiles,cellulosic fibres and yarns,bioformulations,functional textiles,circularity,sustainability,durability,upcycling,fashion textiles,home textiles
Punic and Roman Ancient Warfare of the Naval Battle of Egadi (PRAWN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

PRAWN proposes to conduct the first extensive archaeological and archaeometric investigation of metal defensive armour discovered at the underwater site of the Battle of Egadi, Sicily, Italy (241 BCE). As the final confrontation between Rome and Carthage during the First Punic war (264-241 BCE), the Battle of Egadi played a pivotal role in Mediterranean history, enabling Roman expansion through the central-western Mediterranean by defeating the Punic Empire’s hegemony in Sicily. By applying an integrated, interdisciplinary and multivariate methodology to the recovered artifacts from the submersed site, PRAWN aims to: 1. Develop a comprehensive understanding of the panoplies of the naval warriors involved in the First Punic War (e.g. Roman, Punic, Iberian, Numidian, Gallic, Balearic, Hellenistic, etc.) in terms of typologies, manufacturing, provenance of primary materials and use. 2. Identify metallurgical production groups and gather unprecedented information on copper metallurgy in the central-western Mediterranean during the 1st millennium BCE, including the poorly documented Punic metalworking crafts. 3. Elaborate new tools and protocols for cross-referencing archaeometallurgical results, focusing on samples’ representativity in Heritage Science, in terms of alloy chemical composition and microstructure, and create the first FAIR database on body armour from the Mediterranean western area during the Iron Age, starting with PRAWN’s results.

Keywords: underwater archaeology,metal armour,metallurgy,copper metallurgy,naval battle,punic war,sicily
Connecting Pockets of MetaCity Excellence around the Baltic Sea Region (METACITIES)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Belgium,Finland,Latvia,Estonia,Sweden,Poland
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2023-CONNECT-01, 2023)
Start date: 2023-11-01
End date: 2024-11-30
Duration (months): 13.0
Total project cost (EUR): 532985.27
EU funding (EUR): 499990.63
Participants: 8
Project status: CLOSED

The main objective of METACITIES is to speed up, consolidate, align and leverage the existing MetaCity and Smart City initiatives of the partner regions, and through this, build the world’s leading connected MetaCity Region across the Baltic Sea (BSR). MetaCity is a novel smart city and urban innovation concept, focusing on open innovation which is supported and encouraged by digital environments and social networks. MetaCity is responding to, and leveraging on the post-pandemic transition to virtual co-operation and virtual urban services. MetaCity is an emerging regional policy objective, already in regional policy planning in Oulu Region and Latvia. MetaCity aims to expand ICT-oriented Smart City development to a wider base of regional innovation capabilities and innovation capture, including for example service innovations and social innovations. The METACITIES project connects a balanced mix of MetaCity and Smart City ecosystems: definite global thematic leaders, thematic followers, urban capital areas, mid-size central towns, and more rural regions. It will strengthen ecosystem collaboration between the MetaCity Regions in the Baltic Sea area and prepare the collaboration opportunity space. It will create a joint action plan for Baltic Sea MetaCity Regions and decide the action plan details in interaction with regional funding decision-making METACITIES aims to position the EU BSR area as the World’s leading “Connected Regional Innovation Valley” for MetaCity innovations

Keywords: smart city,metacity,ecosystem,living lab,quadruple helix
Bio-based surfactants from renewable waste streams for the circular economy (PureSurf)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 2475998.75
EU funding (EUR): 2475998.0
Participants: 1
Project status: SIGNED

With climate and environmental concerns topping the global agenda, industries across all sectors are under tremendous pressure to rapidly change their existing fossil-based practices by shifting toward cleaner, greener, more sustainable (in one word: future fit) solutions in business and production, while maintaining economic competitiveness internationally. Surfactants (17 million t/year market globally) are omnipresent in key industrial segments (detergents, personal care, coatings, agrochemicals, pharmaceuticals) and companies are actively looking to shift toward bio-based alternatives while maintaining product performance. Surprisingly, the valorization of renewable waste streams occurring in large quantities for making novel surfactants has not been adequately exploited so far. The reason for this is the lack of fundamentally new technologies in this area. With the credo: Superior performance and clean conscience, PureSurf introduces ground-breaking manufacturing concepts to produce novel high-performance bio-based surfactants from currently underutilized renewable waste streams. In ERC PoC PURE project, novel green surfactants were obtained by green and scalable synthetic pathways, resulting in 2 patent applications. Building on this, the PureSurf validation activities will include: - Upscale at least one gemini anionic and one zwitterionic surfactant structures to 1 kg to validate their properties, using clean starting materials - Upscale (to 5 kg, TRL5-6) at least one selected example using industrial waste streams - Determine properties, ecotoxicity, biodegradability (also anaerobic) as well as performance in industrial applications - Critically compare to existing surfactants, establish a business case and prepare an investor ready technology. The PureSurf team, consisting of leading experts in green chemistry, engineering and business with strong industrial network, aims to establish a spin-off company and become frontrunner in bio-based surfactants.

Keywords: green chemistry renewables circular economy biobased surfactants waste upcycling green startup future proof business life cycle thinking
Uncovering the Proteomic Radial organization within the Eukaryotic Nucleus (PRUNE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Recent evidence gathered in the Bienko Lab indicates that, in addition to DNA, many nuclear proteins including several transcription factors implicated in cell fate determination are non-randomly radially distributed in the nucleus of mammalian cells. This fascinating observation led me to hypothesize that there exist a broad set of nuclear proteins that are arranged along radial gradients in the nucleus, acting as readers of the radial genome architecture. Within this MSCA Postdoctoral Fellowship, I aim at tackling this exciting hypothesis by addressing the following fundamental questions: (i) How are nuclear proteins radially arranged in the nucleus of cells undergoing differentiation towards opposing lineages? (ii) What drives and maintains different radial patterns of proteins in the nucleus? (iii) Is the radial arrangement of proteins in the nucleus functionally relevant? To address these central questions I will first develop an innovative tool to map the spatial arrangement of nuclear proteins radially. I will then apply the newly developed method to chart the radial nuclear proteome in human induced pluripotent stem cells (iPSCs) undergoing differentiation towards different lineages. Finally I will explore the functional implications of the radial organization of nuclear proteins by attempting to rewire nuclear radiality and assessing the effects on gene expression and cell identity. This clearly interdisciplinary project aims at finding an explanation in the spatial organization of the genome and the nuclear proteome to a key question arising from cell and developmental biology: how lineage-specific gene expression programs are set up? With this ambitious proposal I will dive into the exciting field of 3D genome organization while addressing a completely new hypothesis and potentially making ground-breaking discoveries.

Keywords: 3d genome chromatin gene expression nuclear radial organization lineage specification
DAMA-BIOX: Breaking the link between obesity-related inflammation and oxidative stress by bioavailable compounds from apple pomace delivered in novel dairy beverages (DAMA-BIOX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-10
End date: 2027-09-09
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

Overweight and obesity are risk factors for cardiometabolic diseases that can be partially prevented by adopting healthier lifestyles and eating habits, such as increased fibre intake and other bioactive compounds, such as phenolics. However, in the European Union, the proportion of overweight adults varies from 37 to 73%, averaging 53%. DAMA-BIOX uses apple pomace (AP) to recover, purify and encapsulate phenolic compounds (APF) and fibres to unveil the mechanisms of antioxidant and anti-inflammatory properties of the bioavailable fraction in 3T3-L1 adipocytes challenged with supraphysiological concentrations of palmitic acid to simulate obesity. DAMA-BIOX implements the use of an innovative humanised three-dimensional co-culture intestinal barrier model consisting of human enterocytes (Caco-2) and human fibroblasts (CCD-18Co) to recapitulate human intestinal absorption. The use and reuse of AP also target sustainable food production by harnessing agro-industrial side streams, representing a tangible solution to produce functional foods. DAMA-BIOX addresses this aim across four work packages, contributing to the environment, agroindustry’s circularity, and public health. DAMA-BIOX brings together cross-sectoral expertise, strengthens the European capacity for healthier and sustainable innovations, and generates new possibilities for food export. The prestigious fellowship will provide the experienced researcher (PF) with the first step in a new research field that will act as a platform to kick-start the future international academic career. The University of Limerick is the place of renowned subject experts, and exposure to international collaborators will provide the PF with a unique opportunity to grow as an independent researcher.

Keywords: food science zero waste food innovation phenolics bioaccessibility bioavailability inflammation antioxidant
THRON-SEC: Drug-Induced Secretome Profiling for Enhanced Therapy (THRON-SEC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Under normal conditions, cells release proteins (secretome) to regulate fundamental processes like metabolism and immunity. Many diseases and their corresponding treatments involve alterations in the secretome and the cellular microenvironment. Understanding drug-induced changes in the secretome is vital for early assessment of drug efficacy, toxicity, and resistance development. We have developed a metabolic protein labeling technique based on bioorthogonal threonine analogues, THRONCAT, that offers sensitive and non-perturbing analysis of drug-induced changes in the cellular secretome. THRONCAT enables the identification and quantification of secreted proteins in response to drug treatment, even in sensitive cellular systems. We envision that Drug-Induced Secretome Profiling (DISP), holds promise for improving clinical and preclinical drug development by detecting specific signaling proteins and biomarkers early in the development process and validated secreted proteins may serve as biomarkers to assess treatment efficacy during drug development and clinical trials. In this proof of concept proposal we will validate the technical and commercial feasibility of a platform that allows the analysis of the cellular secretome upon drug treatment. THRON-SEC will: 1) Show that secretome profiling upon drug treatment allows the elucidation of a drugs efficacy and mechanism of action as well as early detection of toxicity and resistance markers; and 2) Perform IPR, market and business case analyses to ensure commercial feasibility and entry to market.
Design and Implementation of an Advanced Nonlinear and Non-Gaussian Data Assimilation Algorithm for Bounded Variables in Numerical Weather Prediciton Models. (SENTINEL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Hazardous weather events affecting populated coastal are among the most devastating natural disasters in terms of mortality and economical losses due to their low predictability. Currently, the generation of useful predictions, reliable and anticipated of hazardous weather events affecting populated coastal regions remains an ambitious challenge for the scientific community. Deficiencies in the accurate prediction of such events are tightly related with the initial value problem, which states that better the state of the atmosphere is estimated, the more accurate the forecasts. This problem is addressed by using advanced Data Assimilation (DA) techniques, which play an important role in current numerical weather prediction and is currently at the forefront of atmospheric and oceanic sciences research. However, although using the most current sophisticated DA algorithms, the estimation of the atmosphere is not accurate enough to improve the predictability of hazardous weather events, mainly because their linear and Gaussian underlying assumptions. The main aim of the present project is to go beyond the state of the art in DA by developing and implementing a novel and advanced DA technique that takes nonlinearities and non-Gaussianities into account, enabling us to to improve high-impact weather forecasts. The new DA will be tested in real cases in combination with a high-resolution atmospheric model to improve the predictability of several poorly forecasted Mediterranean Hurricanes. This novel technique will significantly improve global, regional, and climate forecasts. The applicant’s strong mathematical and theoretical skills in DA together with his broad experience running numerical weather models using HPC facilities will facilitate the achievement of the key goals of this proposal. This project will also expand the applicant’s experience, research competencies and professional networks, enhancing the development of his career as an independent researcher.

Keywords: data assimilation,ensemble kalman filter,non gaussian,nonlinear processes,numerical weather forecasts,mediterranean hurricanes