Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OPTIC FIBRE-BASED HYDROGEN LEAK CONTROL SYSTEMS (OPTHYCS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,France,Belgium
Call: Hydrogen and H2NG leak detection for continuous monitoring and safe operation of HRS and future hydrogen/H2NG networks (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2499428.75
EU funding (EUR): 2499428.75
Participants: 7
Project status: SIGNED

Hydrogen has emerged as a required fuel and commodity needed for the decarbonization of the generation, distribution, storage, and energy consumption. Through the EU Hydrogen Strategy, the EC recognised the important role of hydrogen, and the need for the hydrogen market to be significantly scaled up. The boost in hydrogen production and its introduction in the energy market has arised one important issue: leakage of hydrogen during its storage, transportation and distribution. This leakage produces two negative side effects: there is a safety issue derived from the hydrogen’s broad flammability range (4 to 74% concentration in air) and it contributes to a net emmission of greenhouse gases (GHG) by depleting hydroxyl radicals (OH), thus increasing the atmosperic lifetime of methane and influencing tropospheric ozone formation, with an estimate accumulation effect of 5.8% increase over 100 years. The Green2TSO-OPTHYCS project will aim to develop new sensor technologies for continuous leak detectors based on optical fibre sensors technologies which will lead to an increase in the safety level of hydrogen applications, from production to storage and distribution, both in new infrastructure, working with pure H2, and in natural gas repurposed installations and pipelines, contributing to a safe and economically viable implementation of H2 production, transport, and storage processes. OPHTYCS project is built upon 3 conceptual areas: A) Technology pillars analysis and definition of new sensor technology , B) Validation of key use cases (pipelines, HRS and midstream sites (compression , metering stations, etc.) of the new technologies in 3 different controlled validation sites, and C) Aspects of the technologies derived from the use cases, including the assessment of the security and environmental risks evaluations and regulatory framework, and a scalability and cost efficiency study.

Keywords: hydrogen leakage,optical fibre sensors,fiber sensors
Targeting of glycosylation pathways to empower CAR-T therapy of solid tumors. (GlycoCAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2498435.0
EU funding (EUR): 2498435.0
Participants: 1
Project status: SIGNED

Chimeric Antigen Receptor (CAR) T cell therapy uniquely can provide life-long protection against tumor re-emergence upon clearance of even advanced-stage leukemia. However, for the more frequent solid tumor types (carcinomas, lymphomas), clearance of advanced-stage tumors, and especially the subsequent long-term protection, is only rarely achieved. The main reason for this is the multi-pathway immunosuppressive environment that these tumors evolve to overcome the selective pressure imposed by the patient’s immune system. This both hampers the initial attack by CAR-Ts, and often leads to low numbers of long-term persisting CAR-T cells, which tend to be in a state of functional exhaustion. Most attempts at overcoming this, target particular CAR-T cell proteins involved in individual pathways of immunosuppression. However, it is clear from early-stage clinical trials with such engineered CAR-T cells that multiple pathways will need to be tackled at the same time. Inspired by this challenge, I have chosen a radically different path: we are targeting the CAR-T cell glycocalyx, i.e. the assembly of glycosylated structures that forms the outer layer of the cell. The unique property of glycosylation pathways is that they often modulate a large range of cell surface receptor biology at the same time. Excitingly, this new research line has now generated the first highly promising results with the discovery of a single CAR-T glycogene inactivation that results in robust clearance of a benchmark highly immunosuppressive carcinoma rechallenge, in mice that were CAR-T cured from their primary tumor months earlier. Encouraged by these exciting results that demonstrate strong long-term functional persistence of these glyco-engineered CAR-T cells, we have defined a programme to build on this finding and to explore a candidate set of further glycosylation engineering concepts in CAR-T cells, to further improve CAR-T therapy of solid tumors.

Keywords: glycosylation,glyco engineering,immunotherapy,inducible gene expression knockout overexpression
iTEC SkyNex ATC platform (iSNAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Germany,Poland,Lithuania,Netherlands,Norway
Call: Industrial Research & Validation for Connected and Automated ATM (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 17085551.61
EU funding (EUR): 11959886.13
Participants: 8
Project status: SIGNED

iTEC SkyNex ATC platform This project aims at evolving the iTEC platform architecture to support the virtual centre concept, by making use of state-of-the-art digital technologies and underlying architectural principles. The platform evolution will eventually provide a consistent contribution to enhance safety, resilience and scalability of the ATM network, allowing a more flexible provision of ATM services. This technical evolution will enable the full implementation of target architecture defined in the European ATM Master Plan (Phase D) through the instantiation of concepts such as platform as a service (PaaS) ATM data service Provision and highest automation level. This project is proposing the implementation of the most architecturally significant changes defined in the iTEC V3 being already agreed by all iTEC partners. In addition, the project will also continue the research of airspace delegation concept using Virtual Centre technologies, focusing on the delegation of the ATM services provision amongst ATSUs in a D-architecture. This work will be used as the main reference for the activities of the DEVICE project related to D architecture, requiring a strong coordination of both projects and alignment of their project plans.

Keywords: itec,atc,atm,4d,architecture,digital technologies,adsp,atsu,virtual centre
Structure and Regulation of Bacterial Biofilm-Promoting Exopolysaccharide Secretion Systems (BacFilm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: SIGNED

Bacteria are commonly defined as unicellular organisms; however, they constantly exchange substances and information with their confrères and the environment, and can efficiently shelter themselves and achieve homeostasis by building multicellular collaborative macrocolonies called biofilms. Members of these sessile communities can undergo significant functional differentiation and are typically embedded in complex extracellular matrix that secures both mechanical protection and a medium for intercellular exchange. Importantly, the switch between sessile and motile life-styles in pathogenic bacteria can correlate directly with the development of chronic vs. acute infections, whereas extracted bacterial matrix components can find a variety of beneficial biotechnological applications. Exopolysaccharides (EPS) are a major biofilm matrix component and are typically produced by trans-envelope secretion nanomachines, many of which are controlled at multiple levels by the intracellular second messenger c-di-GMP. Here, we will consolidate our expertise in biofilm formation, cyclic dinucleotide signaling, bacterial secretion and integrative structural biology to decipher EPS secretion system assembly and function in several medically and industrially relevant species. We will use complementary recombinant and in situ structural biology approaches together with established genetic and imaging techniques to decipher the molecular events controlling EPS biogenesis from transcription initiation, interdependent protein folding and cooperative subunit interactions; through secretion system assembly, formation of supramolecular secretory nanoarrays and EPS modifications; to harnessing the biosynthetic processes for the engineering of novel anti-infectives or beneficial EPS superproducers. Over the last years we have spearheaded these studies by unprecedented mechanistic insights into several secretion systems and have demonstrated the feasibility of such an ambitious project.

Keywords: bacterial biofilms,bacterial secretion,c di gmp signaling,cryo em,x ray crystallography,membrane protein biology,exopolysaccharides,biopolymers
Combined Use of EGNSS and Copernicus Data to Develop Innovative Downstream Services for the Users from Chile and Colombia (COMUNIDAD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Czechia,Chile,Spain,Colombia,Latvia
Call: Designing space-based downstream applications with international partners (HORIZON-EUSPA-2022-SPACE, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 1499893.75
EU funding (EUR): 1499893.75
Participants: 8
Project status: SIGNED

COMUNIDAD aims at developing, testing, and implementing a framework that will make use of Copernicus data from agriculture, forestry and rural development in Chile and Colombia. It will develop solutions integrated on the COMUNIDAD platform with different sources of data. The COMUNIDAD Platform will be important base for the use of EGNSS and sharing of expertise with public and private entities from the target countries to introduce EU-space based applications and to use of Copernicus data, to develop jointly algorithms, services and products, which serve local user needs. The interaction with each Pilot Application in Chile and Colombia will feed to long-term policy strategy development, aiming at bringing about the transition into the new paradigm of sustainable agriculture and forestry growth. The combined use of EGNSS and Copernicus to develop innovative downstream applications combining positing navigation and timing with Earth observation services will be an essential part of the COMUNIDAD development through pilot applications in Chile and Colombia with the direct involvement of regional end users, decision makers and support organisations. This approach is not only demonstrating the possibilities of potential transfer of the results and addressing the potential barriers, but as well introducing the added value for developing new markets, information sharing, open access and transparency. The platform is combining existing components and services for new target regions where potential for utilization is expected. The COMUNIDAD will address 4 main Scientific Objectives via 6 WPs. The cooperation of 9 partners is envisaged, from them 5 are from Chile and Colombia and 4 from EU.

Keywords: copernicus,gnss,remote sensing,forestry,agriculture,coffee,environment,snow
Smart Synergy Mechanism between Electric Vehicle Charging and Flexibility Markets (ChargFlex)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 3
Project status: SIGNED

Rapid integration of Electric Vehicles (EVs) in the transport sector is the key to achieving the Green Deal decarbonization targets. However, EV adoption is still low for several reasons, mainly concerns about the lack of charging infrastructure from the EV drivers' view, known as range anxiety. Many studies believe deploying more public EV charging stations (EVCSs) can ease this anxiety among EV drivers. Still, EVCSs are not yet widely available due to profitability issues and putting more stress on the grid. While the growth of the EVCSs is moving slowly, the number of household charger installations is growing rapidly. However, scarce studies have investigated the potential of household chargers in providing public charging services. Further, many households are already equipped with renewables and sell the surplus energy to the grid through local flexibility markets. With renewables, household chargers can provide cheaper charging services while minimizing the negative grid impacts of EV charging. This project intends to alleviate the range anxiety in two ways. First, we will enhance the charging infrastructure availability by encouraging households to sell surplus energy to EVs through a market framework called the charging market, besides flexibility markets. We will design a coordinated bidding strategy model from the household viewpoint based on AI to maximize profit from the two markets (Work Package 1). Second, we will improve charging infrastructure accessibility by developing an AI-based charging recommendation model to guide EV drivers on when and where to get recharged (Work Package 2). Finally, we will conduct software implementation and real-time performance validation of the proposed AI-based models (Work Package 3). The complementarity between me, the host supervisor's profile, the environment provided by the host, and the secondment ensure the achievement of this timely and innovative project and the dissemination and exploitation of the results.

Keywords: electric vehicle charging,charging infrastructure,renewable owner household,household participation
Pixelated polariton filters for multichannel hyperspectral lensless imagers (PolaritonPixels)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Fluorescence microscopy is a fundamental tool in biomedical research, pharmaceutical development, and clinical diagnostics, yet conventional systems remain costly, bulky, and impractical for scalable or portable applications. PolaritonPixels introduces a lensless multicolour fluorescence imaging platform that integrates arrays of narrow-band polariton filters directly onto CMOS imaging chips, eliminating the need for traditional bulky optics and filter wheels. This breakthrough enables simultaneous spectral discrimination of multiple fluorophores in a compact, cost-effective, and scalable format, making high-quality multicolour fluorescence imaging more accessible for emerging applications such as high-throughput screening and point-of-care diagnostics. This 18-month project will advance PolaritonPixels from TRL 2-3 to TRL 4, demonstrating a fully functional prototype with validated multicolour fluorescence imaging performance. The system will be optimized to ensure precise spectral separation, high signal-to-noise ratio, and stable imaging performance across diverse biological applications, including live-cell imaging, tissue-scale fluorescence analysis, and multiplexed assays. By addressing key technical challenges and validating the technology’s real-world applicability, the project will position PolaritonPixels as a novel alternative to traditional fluorescence microscopy. By significantly reducing cost, complexity, and footprint while maintaining high imaging performance, PolaritonPixels has the potential to democratize microscopy, enabling broader adoption in biomedical research, pharmaceutical development, and decentralized diagnostics. The project will lay the foundation for further commercialization and scale-up, supporting an EIC Transition application to bring this disruptive imaging technology to market.
Distributed Coordinated Access Point (DCAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In this project, we aim to validate a low-cost Cell Free massive MIMO solution for ultra-reliable and low-latency wireless communication based on Wi-Fi technology. Our solution, called DCAP or Distributed Coordinated Access Point, is enabled by integrating distributed customized Wi-Fi 6 access points with the synchronous fronthaul technology developed in ERC ATTO. The following research innovations will be explored and demonstrated: 1. Accurate time synchronization of the distributed APs with the Bit-Interleaved Sigma-Delta-Over-Fiber Fronthaul Network (BISDoF) as developed in the ERC Advanced Grant ATTO (No.695495). This novel fronthaul solution uses low-cost commercial optical transceiver modules connected with multi-mode optical fiber and is hence way more cost-effective and flexible than coaxial cables. A time synchronization accuracy below 10 ps is targeted. 2. Low-latency operation of distributed APs by exploiting the new OFDMA (Orthogonal Frequency Division Multiple Access) feature in the Wi-Fi 6 standard and extending it with beyond Wi-Fi 6 and Wi Fi 7 capabilities in UGent-IDLab’s open full-stack openwifi prototyping platform, with embedded wireless Time-Sensitive Networking (TSN) capabilities. 3. Full compliance of the highly customized APs with Wi-Fi 6 Commercial-Of-The-Shelf (COTS) clients. 4. Distributed beamforming by coherently combining Resources Units (RUs) from multiple distributed APs, thereby adding an extra degree of flexibility and scalability to the system, as different RUs (subsets of OFDMA subcarriers) in the same channel can simultaneously serve different Wi-Fi clients. Besides the technical evaluation of the DCAP proof-of-concept, the project will also explore potential valorization opportunities. Valorization will be facilitated by an already existing IP portfolio and an established industrial advisory committee.
Drug Optimisation in LMICs of Pregnant HIV women and their Infants: temporary switch to CAB/RPV long acting injections (DOLPHIN-3)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Netherlands,United Kingdom,Uganda,South Africa
Call: Implementation research/real life assessment of existing interventions in women and children’s health (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 3205161.25
EU funding (EUR): 3205161.25
Participants: 5
Project status: SIGNED

Sustained ART use is essential for achieving SDG3 by reducing HIV burden and promoting maternal and infant health. Ensuring consistent adherence and engagement in care is crucial to achieving UNAIDS 95-95-95 viral suppression targets (in treated individuals) by 2030. Despite ART's success, low adherence presents a significant barrier to maintaining long-term viral suppression. Challenges are notably heightened in postpartum WLHIV, as transition into motherhood introduces a range of changes and stressors that can significantly impact adherence. Therefore there's an urgent need to prioritise interventions enhancing engagement and promoting adherence, inorder to achieve viral load suppression and prevent mother to child transmission. DOLPHIN3 aims to operationalise an implementation project using a mixed methods approach to generate evidence on optimal use of long-acting injectable ART as a strategy to improve adherence rates and overall health outcomes among postpartum women in South Africa and Uganda. The project's objectives are to: i. establish effectiveness of a temporary switch to cabotegravir (CAB)/rilpivirine (RPV) LA as a bridging strategy during breastfeeding, ii. explore strategies to safely re-establish oral ART after discontinuation of CAB/RPV LA, iii. explore maternal, infant and breastmilk pharmacokinetics, and iv. engage with stakeholders to generate insights for sustainable future deployment of LAI. The DOLPHIN consortium possesses a proven track record in conducting clinical trials specifically in the population of women initiating ART late in pregnancy. Our proposed project aligns with the EDCTP3 broader objectives of evaluating the real-life impact of existing interventions in women and children's health and improving maternal, neonatal, and child health in sub-Saharan Africa. Our proficiency in implementation research empowers us to transform our research findings into practical recommendations for healthcare systems and policymakers.

Keywords: postpartum period,adherence,long acting antiretrovirals,cabotegravir,rilpivirine