Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TURN-TAKING AND TURNING POINTS IN VIOLENT ENCOUNTERS. TOWARDS AN EXPLANATORY THEORY OF HOW CONFLICTS IN URBAN PUBLIC SPACE BEGIN, TRANSFORM AND END (TURNING VIOLENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2499744.0
EU funding (EUR): 2499744.0
Participants: 2
Project status: SIGNED

Although violent police-civilian and civilian-civilian encounters constitute a tiny sliver of the social interactions that take place each day, their consequences can be far-reaching. Images of assailants committing ‘bestial’ violence against vulnerable victims arouse public fear and indignation, while the excessive use of force by police undermines public trust, cooperation and the rule of law in democratic societies. Depicting such violence as ‘senseless’ moreover obscures the fact that violent action has meaning to the assailants. Based on the granular analysis of 126 publicly available phone camera recordings of real-life interpersonal conflicts in Paris, London and Berlin, the research program will advance an empirically grounded theory that explains how non-violent altercations between strangers in public space develop into encounters in which physical violence is the dominant mode of interacting, especially one-sided violence against vulnerable/subdued victims. The program breaks new scientific ground by: (1) showing that episodes of interpersonal conflict can be causally explained by understanding how the antagonists and their audiences (co-present peers, colleague police officers, unknown bystanders) structure their interactions in culturally meaningful ways; (2) analysing how slurs, insults, and provocations pertaining to race, ethnicity, class, gender and age as well as differences in policing practices influenced the trajectories of civilian-civilian and police-civilian conflicts; (3) developing the methods of ethnomethodological/conversation analysis to transcribe and analyse in meticulous detail how sequences of bodily actions and verbal utterances become turning points towards the beginning, transformation, and ending of violence; and (4) advancing the scientific use of now ubiquitous phone camera data.

Keywords: ethnomethodology multimodal analysis video analysis violence in public urban space interpersonal conflict
New bio-based and sustainable raw materials enabling circular value chains of high performance lightweight biocomposites (R-LIGHTBIOCOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,United Kingdom,Netherlands
Call: Advanced lightweight materials for energy efficient structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4201176.0
EU funding (EUR): 4201176.0
Participants: 18
Project status: SIGNED

New lightweight High-Performance Composite (HPC) materials and efficient sustainable processing technologies will have an enormous environmental and performance benefit in all sectors of application. However, current sustainable HPC application is limited to large sectors due to their limitations in terms of long processing times, high prices and low recyclability. To overcome these limitations, r-LightBioCom propose a paradigm shift in the way HPC are manufactured and recycled, unlocking sustainable-by-design production of lightweight HPC. Therefore, the project will enable new circular value chains towards r-LightBioCom results, contributing to environmental-related EU goals and reducing the HPC waste generation and the use of non-sustainable fossil resources. To this end, a sustainable catalogue of new advanced biobased and recycled HPC materials will be initially developed with inherent recyclability properties (at least 3 new types of bio-resins, 4 new biomass-derived nanofillers and additives, and 3 families of sustainable fibre-based textile products). To reduce current associated manufacturing costs and high energy consumptions and emissions, efficient processing techniques will be developed (2 new fast curing techniques) combined with recycling technologies for the new catalogue of materials to reduce waste generation and induce circularity. A new open method and related tools (Coupled Ecological Optimisation framework) will promote and standardise holistic sustainable HPC design, modelling and systematic optimisation, leading to continuous sustainable catalogue growth and inclusion of new families of biobased, recyclable lightweight HPC at competitive cost. All results will be validated in 3 use cases at automotive, infrastructure and aeronautic industries with specific business cases, contributing to establishing new resilient, sustainable and innovative value chains in the EU HPC industry, promoting a change of paradigm from linear to circular ones.

Keywords: bio resins bio additives natural fibres,recycled fibres,fast curing,ligithtweight composites,high performance composite,recycling,sustainable by design framework,circular value chains
Exploiting the multifunctional properties of polyphenols: from wastes to high value products (PHENOCYCLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Romania,Spain,Uzbekistan,Poland,Colombia,Argentina
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 464600.0
EU funding (EUR): 464600.0
Participants: 10
Project status: SIGNED

PHENOCYCLES is addressing the environmental concern derived from agro-industrial wastes proposing their exploitation for obtaining important bioactive molecules (polyphenolic compounds: PP), to be utilized for different purposes, with a typical circular economy approach. PHENOCYCLES aims at exploring innovative uses of PP and at validating methods for their extraction with a green chemistry approach. PP extracted from agro-industrial wastes (grape, apple, berry pomaces) and herbs with therapeutic value will be purified/fractionated with pilot-scale nano/ultrafiltration membranes to recover different PP fractions, to be employed in four distinct sectors: • human health: synthesis of substances for photodynamic therapy (PDT) and drug delivery (DD), development of innovative phytocarrier systems, formulation of PP loaded micro/nano-scale systems, development of new food supplements (nutraceutics), and hypoallergenic cosmetics. • plant production: PP-based nanomaterials for plant protection against soil-borne pests, to increase plant resistance to stresses, impacting on plant-organisms’ trophic interactions. • environment protection: use of PP as sensitizer or intermediate in the synthesis of materials for water disinfection and advanced oxidation processes (AOPs). • material sciences: synthesis of metal based oxide nanostructures useful for photocatalytic applications. To foster future exploitation of the innovations, a thorough assessment of the stakeholders’ perception of their adoptability will be performed applying a participatory approach together with several innovative dissemination activities based on visual media. The interdisciplinary exchanges planned in PHENOCYCLES are thus expected to increase the knowledge of researchers, particularly young ones, on the different methods utilized by the partners fostering further developments in medicine, pharmacology, crop protection, food preservatives, nutraceuticals, cosmetics, and other industrial applications.

Keywords: polyphenols,circular economy,nutraceuticals,biostimulants,drug delivery,cosmetics,plant protection,social studies
STONE-WORK: collective achievement in Anglo-Irish architectural production, 1700-1800 (STONE-WORK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2499708.0
EU funding (EUR): 2499708.0
Participants: 1
Project status: SIGNED

STONE-WORK challenges the perception of architecture as a primarily conceptual activity by shifting focus from individual to collective achievement. Despite the emphatic materiality of architecture its history remains dominated by a sequential model which privileges the agency of individuals and ideas. STONE-WORK’s fundamental premise is that architecture results from a cumulative sequence of actions involving an array of actors, great and small. There can be no buildings without materials and no materials without those who procure, transport, and fashion them. How can design be related to the material from which it takes form and the skills which give it form? Though interdependence of systems and actors is a key scientific concept, it has had inadequate impact on the study of early modern architecture. Stone, the most valued building material of the period, offers a way into architectural process which forces us to include the broader community involved in the making of buildings. No other medium so fully encapsulates the sequential nature of architectural production involving a wide range of agents of varying skill and authority. Revealing stone’s hidden trajectory from quarry to wall, floor, column, and chimneypiece will probe the nexus of skills, techniques, and support mechanisms developed by communities in its sourcing, supply, and fashioning and the impact of these processes upon building activity. This cross-disciplinary research, combining the history of architecture and craft with geology, will produce the first holistic analysis of architecture and stone production, thereby interrogating the relationship of material, design, and execution. The prodigious classical architecture of Britain and Ireland in the eighteenth century, richly documented in untapped archival material, is an exemplary episode in monumental stone building which offers a meaningful, accessible, and feasible route into the complex problem of interdependence in architectural production.

Keywords: architectural history architectural ornament craft history sculpture history stone marble
Biorthogonal Catalytic Scaffold for in situ Personalized Cancer Chemo-Immunotherapy (BiorthoCat-Immuno)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

In this fellowship I will leverage the recent advances in biorthogonal chemistry to develop an implantable catalytic hydrogel for chemoimmunotherapy through transition metal-mediated biorthogonal drug uncaging. The past decade saw incredible advances in the field of cancer immunotherapies, with immune checkpoint blockade therapies and chimeric antigen receptor-T cell therapies demonstrating clinical efficacy. However, issues still exist, as life-threatening side effects and limited patient response. Therefore, there is a huge need for innovative solutions to improve immunotherapies outcome. This project seeks to apply the materials and reaction engineering competence of the applicant, together with the biomaterials expertise of the Stevens lab (Karolinska Institute) to design a nanocatalyst-doped hydrogel with tailored geometry, as the first biorthogonal catalytic system for cancer immunotherapy. The biomaterial developed in this fellowship will address cancer immunotherapy through a completely unexplored approach: catalytic uncaging of non-toxic prodrugs to their active form through metal-catalyzed depropargylation reactions, completely orthogonal to biological processes. The implant will enable uncaging of two toxic drugs: a chemotherapeutic – doxorubicin – inducing immunogenic cell death, and an immunostimulant drug – R848, a TLR7/8 agonist. The combination of drugs activated by the implant will enable localized cancer cells death with release of cancer-specific antigens, antigens then uptaken by antigen presenting cells, eventually eliciting antitumor immunity, towards a personalized cancer vaccine. The design of the scaffold will be guided by principles of biomaterials design and catalytic reaction engineering. Working in the Stevens lab I will access state-of-the-art equipment for materials synthesis and characterization, and cutting edge facilities to study the cell-material interactions in vitro and characterize the efficacy of the envisioned treatment.

Keywords: biorthogonal chemistry,reaction engineering,immunotherapy,immunoengineering
SCIENTIFIC EXPLOITATION OF SPACE DATA FOR IMPROVED IONOSPHERIC SPECIFICATION (DISPEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Bulgaria,Poland,France
Call: Scientific exploitation of space data (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1492875.0
EU funding (EUR): 1492875.0
Participants: 5
Project status: SIGNED

DISPEC project aims at the exploitation of bottomside and topside ionospheric data, provided by space missions – such as Swarm, DORIS, GRACE, GRACE-FO, Spire, COSMIC-2– and by ground-based GNSS receivers and ionosonde sounders, to support research activities for improved ionospheric specification, through the derivation of high-level data products. The project outcomes have the potential to complement the ESA Space Science Archives and the Space Weather Network, the data collections provided by the global networks of ionosondes and GNSS ground based receivers, and to enhance the capacity of European Research Infrastructures.
CAPACITATION OF A PORTUGUESE R&I CENTRE OF EXCELLENCE FOR PLANT PATHOGENS DETECTION AND CONTROL (BIOMEHEALTH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Portugal,Netherlands,Italy
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 1499851.31
EU funding (EUR): 1499851.31
Participants: 3
Project status: SIGNED

BiomeHealth aims to strengthen European and Portuguese R&I on agro-food systems that face climate change and new/recurrent pathogens, with the support of Wageningen Univ. & Research (WUR, NL) and Bologna Univ. (UNIBO, IT). Global trade and climate change favor the establishment of new pathogens in Europe. Portugal needs to boost R&I and education/training to empower a new generation of researchers in this field. BiomeHealth has two R&I objectives, and four capacitation objectives aligned with the Twinning call. WUR (precision pathogens detection), and UNIBO [VOC-biosensors, Biological Control Agents, and SynComs] will develop R&I and capacitation of the widening partner, Requimte/UP that leads the national research in agrifood. This capacitation networking will use groundbreaking concepts of plant microbiome, precision detection, and engineering of synthetic communities (SynComs) of BCAs (supported by artificial intelligence, AI). BiomeHealth structure has six interdependent WPs: WP1 is for Coordination and Management; WP2 deals with R&I on precision detection and control of phytobiomes also challenged by climate change (as a case study we will use Pear/Apple trees under an RCP8.5 climatic scenario, and challenged with Erwinia amylovora, and Stemphylium vesicarium). New detection tools/matrices (e.g., aerobiomes), dynamics host-microbiome-pathogen, and SynComs, will be unveiled/tested for the RCP8.5 condition. WP3 (precision detection) and WP4 (Control using SynComs) are dedicated to the capacitation of Requimte/UP, with dedicated short-term visits, training/advanced courses, summer schools, etc. WP5 will build a sustainable structure through a R&I roadmap of Requimte/UP for 2030, and the creation of a Centre of Plant Pathogen Detection and Control. Finally, WP6 deals with dissemination/communication. This 36-month twinning will boost the precision detection/control of diseases in Portugal, increasing its networking competitiveness and international recognition.

Keywords: phytobiome emerging pathogens,synthetic communities,climate change,capacitation on disease control
PEP4LEP 2.0 - Chemoprohylaxis for leprosy: comparing the effectiveness and feasibility of a community-based intervention to a health centre-based intervention in Ethiopia, Mozambique, and Tanzania. (PEP4LEP 2.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Netherlands,Germany,Mozambique,Ethiopia,Tanzania, United Republic of
Call: Funding to successfully finalise EDCTP2-funded clinical trials that were negatively impacted by the COVID-19 pandemic (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 1780303.75
EU funding (EUR): 1780303.75
Participants: 6
Project status: SIGNED

BACKGROUND - Leprosy is a significant public health problem. Early detection, treatment, and prevention are crucial to reduce transmission and disabilities. The World Health Organization (WHO) recommends single-dose rifampicin post-exposure prophylaxis (SDR-PEP) for screened contacts of leprosy patients. The PEP4LEP 2.0 study builds upon the EDCTP2-PEP4LEP project to identify the most effective intervention to screen individuals for leprosy, other skin neglected infectious diseases (skinNIDs) and common skin diseases, and to provide SDR-PEP. The study takes place in leprosy high-endemic areas in Ethiopia, Tanzania and Mozambique. It determines which intervention has most effect on leprosy case finding and detection delay. However, the COVID-19 pandemic hampered the initial PEP4LEP study through delayed interventions and medication shortages, affecting the main outcome indicator: case detection delay. METHODS - PEP4LEP 2.0 is a two-arm, cluster-randomized implementation trial to compare two interventions: 1) a community-based skin camp intervention, screening 100 leprosy patient's community contacts for leprosy and other skin diseases, and administering SDR-PEP; and 2) a health centre-based screening intervention, inviting leprosy patients’ household contacts to health centres for screening and SDR-PEP. To ensure a scientific sound analysis, PEP4LEP 2.0 collects additional data, increasing the sample size by 25%, to understand the pandemic's effects and enable analysis with and without COVID-19 influences. Skin camp organization, skinNID distribution, health staff capacity and acceptability will also be studied. Results will be modelled to assess the long-term impact related to costs. IMPACT - PEP4LEP 2.0 results will reflect scientific, societal and economic impact towards reduced leprosy transmission. They will be disseminated to all stakeholders: scientists, policymakers, WHO, health staff, affected communities, NGOs and the general public in the EU and Africa.

Keywords: implementation research,chemoprophylaxis,leprosy hansen s disease,cost effectiveness,neglected infectious diseases nids,neglected tropical diseases ntds,dermatology,mhealth,app,africa
TRUSTWORTHY AI FOR IMPROVEMENT OF STROKE OUTCOMES (TRUSTroke)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,Belgium,Switzerland,Italy,Netherlands
Call: Trustworthy artificial intelligence (AI) tools to predict the risk of chronic non-communicable diseases and/or their progression (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 6076437.5
EU funding (EUR): 6076437.5
Participants: 13
Project status: SIGNED

TRUSTroke proposes a novel trustworthy by design and privacy-preserving AI-based platform to assist clinicians, patients and caregivers in the management of acute and chronic phases of ischemic stroke, based on the integration of clinical and patient-reported data, outcomes and experience for a trustworthy assessment of disease progression and risks. enabling more personalised and effective management of stroke, as well as providing inter-hospital benchmarking and sharing best practices. Specifically, TRUSTroke will address to risks of: i) clinical severity at discharge ii) clinical worsening leading to unplanned hospital readmissions, iii) poor mobility, incomplete recovery and unfavourable clinical long-term outcomes; iv) stroke recurrence. To this purpose, a Federated Learning infrastructure will enable multiple clinical sites to build several trustworthy AI based predictive models by leveraging stroke data without compromising privacy and implementing best-in-class security and privacy protocols. FAIRified clinical data from leading European hospitals and outpatient monitored data from a remote home-care system, will be used (i) to train and validate trustworthy AI models for stroke prediction; (ii) to personalise patients´ assessment of cardiovascular risk factors, treatment compliance and communication with healthcare professionals. TRUSTroke platform will be trustworthy by design since it will be compliant with the recognized guidelines for building FAIR resources and trustworthy AI systems, including the need for transparency, explainability, robustness, accountability, accuracy and security of the learned AI models. A series of User Experience studies will be performed to increase the usability of the platform and improve the communication to the end-users. A final proof of concept clinical study, conducted by world class stroke centres, will ensure the highest level of trustworthiness of TRUSTroke.

Keywords: stroke,federated learning,federated data,simulation,preventive medicine,ai