Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DESIGN STUDY FOR A EUROPEAN INFRASTRUCTURE ON ADVANCED GENOMICS TECHNOLOGIES (EASIGEN-DS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Sweden,France,Belgium,Estonia,Croatia,Italy
Call: Research infrastructure concept development (HORIZON-INFRA-2024-DEV-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 2999266.0
EU funding (EUR): 2999266.0
Participants: 18
Project status: SIGNED

Innovation in the genomics field is extremely intense and requires high up-front investments. The toolbox of sequencing platforms with unique features that require specialized training and leverage extensive cross-functional expertise, is rapidly expanding. The EASIGEN-DS project evolves from two EU infrastructure projects that have proven to be very successful in providing access to cutting-edge DNA sequencing technologies to hundreds of researchers. Here, we propose to carry out a design study for establishing a new European Research Infrastructure on Advanced Genomics Technologies, EASIGEN. In order to develop an excellent scientific, technological and operational design, we will conduct landscape studies, stakeholder consultations, and community surveying. In parallel, we will seek for the support and commitment of several national and EU stakeholders and user communities through a multi‐faceted dissemination plan. We envision that EASIGEN will encompass: 1) a Technology Platform that will offer state-of-the-art genomic analysis methods, such as single-cell genomics, spatial genomics and long-read sequencing, as well as population-scale genomics capacity; and 2) a Support Platform that will provide standardization tools, training, co-innovation with industry, and consulting for smaller facilities, including those in widening countries. Both platforms will serve a vast community of users from the health, biomedical and life science fields. The consortium brings together 1) a network of eleven genomics facilities with distinct application specialities. and an aggregated sequencing capacity of >450,000 human genomes per year; 2) four partners with specific and crucial expertise: data stewardship, ethical, legal and social implications, socio-economic impact and innovation. The new infrastructure will strengthen the European Research Area, promote interconnections within the ESFRI landscape, and boost an innovative biotechnology-based industry.

Keywords: sequencing,dna,rna,single cell genomics,spatial genomics,fair data,bioethics,training,quality,capacity building,user communities,research,innovation,health,life sciences,impact
Innervation-driven mechanisms of bile duct development (Neuro-biliary talk)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-12-31
Duration (months): 28.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

While liver development is well-studied, the signal initiating tubulogenesis of bile ducts therein remains to be identified. Neurites are present in the liver before bile duct tubulogenesis, and in other organs, innervation can instruct tubulogenesis. However, a role for liver innervation in biliary tubulogenesis has not been shown. Preliminary data from my host lab suggest a strong link between both processes: Defective biliary tubulogenesis caused by Notch mutations in Alagille syndrome (ALGS) is preceeded by a lack of liver innervation. I will test the hypothesis that intrahepatic innervation initiates biliary tubulogenesis. First, I will apply 3D staining and imaging techniques to study the establishment of intrahepatic innervation at multiple timepoints during development, and quantify characteristics of innervation in healthy and ALGS mice in depth using automated image analysis. Secondly, I will investigate if liver innervation is required for tubulogenesis by performing nerve ablation studies and analyzing its effect on biliary cells. Finally, I will establish a method to perform transcriptional profiling of liver innervation. The liver is only innervated by nerve endings from extrinsic neurons, and these neurons have their cell bodies in ganglia outside of the organ where also other neurons reside. It has thus not been possible to isolate these cells from the liver and analyse their expression profiles. Using a viral barcode library to label neurons and their axon endings, I will perform single-cell RNA sequencing on those ganglia, and identify and characterize the cells innervating the liver. Enabling expression profiling of extrinsic nerves will be a game changer in the field of organ innervation, and can be applicable to numerous other fields. This project will provide fundamental insights into the developmental functions of liver innervation and the molecular mechanisms underlying biliary tubulogenesis, providing a basis for future therapeutics.

Keywords: bile duct morphogenesis innervation notch signaling liver development
Stochastic interacting systems: Limiting Behavior, Evaluation, Regularity and Applications (LiBERA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Italy,Finland,France,Germany,Japan,United States,United Kingdom,Portugal,Colombia,Canada,Brazil,Switzerland,Belgium,Sweden,Mexico,Chile
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 924600.0
EU funding (EUR): 924600.0
Participants: 24
Project status: SIGNED

This SE aims at addressing a number of challenging mathematical problems related to stochastic interacting systems, with particular emphasis on the regularity properties of the solutions, their limiting behaviour and numerical computation. The equations we analyse arise from the modelisation of real-world phenomena in several fields of application, including spiking neural systems, hydrodynamics and financial/energy markets, and share nonlinearity as a common underlying trait. Critically, nonlinearity intertwines with other relevant features that include: low regularity of the coefficients, noise degeneracy, jump-diffusion dynamics, and high-dimensionality. The study of stochastic interacting systems is highly multidisciplinary from a two-fold perspective. On one hand, they have become a widespread modelling tool in a variety of applications. For example, they are used to model human neuron interfaces, particle systems, but also interacting agents in economics and finance, in relation to managing risk and decentralised production of renewable energy. On the other hand, the set of mathematical and computational tools needed to reach a holistic understanding of stochastic systems is very vast: ranging from stochastic (partial) differential equations, random measures, rough paths, gradient flows in metric measure spaces, numerical probability and computer simulation. We provide a team of experts that analyse stochastic systems integrating several approaches and techniques. The complementary expertise across the network, together with the consolidated experience and excellence of the key participants in their research areas, places our network in the privileged position to make relevant contributions across interconnected research fields, and to contribute to the training of the early career researchers involved in the project in an exciting field of pure and applied mathematics, with the possibility of boosting their careers in both academic and non-academic sectors.

Keywords: stochastic partial differential equations,interacting particle systems,kinetic pdes,numerical probability,stochastic control,langevin equations,mean field games,mckean vlasov,hawkes process
Adapted Biomineralisation for municipal solid waste reuse into Concrete (AdBiCon) (AdBiCon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-02
End date: 2028-02-01
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The AdBiCon project will develop innovative techniques to immobilise bacteria in Municipal Solid Waste (MSW) bottom ashes for their effective reuse as precursors in alkali activated concrete (AAC). The incorporation of MSW in AAC enables the reuse of locally generated landfill waste in construction materials, offering a path to decarbonisation of the construction sector. Presently, replacing >10% Portland cement with MSW bottom ashes affords concrete with higher water demand, air content and porosity compared to Ordinary Portland cement (OPC) concrete, leading to strength loss and frequent cracks. This concrete also exhibits fast pH decline, which facilitates corrosion. This warrants for the development of new approaches to exploit bottom ashes for improved MSW-based concrete. Inspired on the Pantheon dome, biomineralisation is a nature-inspired method to strengthen, repair and protect construction materials, leveraging on bacteria-induced calcium carbonate precipitation to heal microcracks. Biomineralisation lends itself to the use of waste-derived materials as carrier and substrates for bacteria because fractional impurities and material inhomogeneity are not detrimental for the intended application. This creates a huge opportunity for waste reuse and will expand AAC’s enormous potential use for greener infrastructures. AdBiCon will study (1) the bacterial carrier capacity of MSW bottom ashes to protect the bacteria from a harsh environment; (2) the potential of MSW bottom ashes as bacterial nutrient medium & substrate; (3) the mechanisms of bacteria-mediated inhibition of MSW-containing concrete corrosion in comparison to reinforced OPC concrete; (4) the potential of self-healing bio-enhanced MSW concrete to prolong the service life of infrastructure, by demonstration and validation, benefitting the concrete industry. This interdisciplinary engagement with experts and stakeholders will significantly broaden the fellow's scientific skills and research portfolio.

Keywords: biomineralisation,self healing,municipal solid waste,alkali activation,concrete,durability
Innovative numerical methods for non-Newtonian flows and porous media (InNoPor)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain,United Kingdom,Germany,Chile
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 210420.0
EU funding (EUR): 210420.0
Participants: 8
Project status: SIGNED

The InNoPor project focuses on developing and analyzing innovative numerical methods to solve complex problems in engineering and science involving non-Newtonian flows and porous media. The project will address realistic applications such as volcanology and chromatographic filtering. The network includes eight universities and research centers from Spain, the UK, Germany, and Chile, fostering long-term collaboration. Advanced modeling of non-Newtonian flows in porous media plays a crucial role in soil remediation, water purification, and the development of sustainable technologies for agriculture, energy, and environmental management. InNoPor aligns with several UN Sustainable Development Goals (6, 7, 9, and 13) and aims to contribute to European sustainability and technological innovation priorities. The project seeks to create impactful solutions for academia and industry by leveraging cutting-edge numerical techniques and interdisciplinary collaboration.

Keywords: applications of mathematics in science porous media geophysics inverse problems
Automated turnkey insect rearing farm. Enabling farmers to produce their own sustainable insect protein feed (FarmInsect)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3575125.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

FarmInsect responds to the global need for alternative protein sources for animal feed in a sustainable and efficient way for farmers. FarmInsect is the first Insect company to put existing farmer in the center of the solution. Utilizing BSF larvae in a full closed loop system, farmers feed the larvae on organic sidestreams. Just as nature’s perfect upcycling machines, larvae convert organic residues to create high-quality protein to feed animals. With FarmInsect, a livestock farmer can produce up to 1.000tn/yr of BSF larvae at €800 vs. 1.350€/t of fishmeal towards replacing dependency on global markets. Key to farmers is the healthy value of larvae feed for animals. The BSF larvae contain natural immune-boosting peptides that improve the immune system of farm animals. Insects as feed reduce abnormal behavior such as feather picking in chickens or tail biting in pigs. Furthermore, added value organic fertilizer is produced as byproduct.

Keywords: entomology,insect rearing,protein feed
Place and Empire in Irish Literature and Culture (Place and Empire)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 265647.84
EU funding (EUR): 265647.84
Participants: 2
Project status: SIGNED

‘Place and Empire’ investigates the relationship between medieval Irish topographical literature and the development of medieval Irish imperialism and anti-colonialism. This project shows that Irish topographical literature--known as "dindshenchas"--has always been a political tool, and that was initially cultivated to translate ideas of classical imperialism onto an Irish landscape. Using the Latin epic tradition, Irish literati conceptualised Irish imperialism by composing origin narratives which validated authority over places. Between the 9th and 12th centuries, these ideas were encoded into narratives about politically significant places under the patronage of dominant Irish dynasties. In the wake of the Anglo-Norman invasion in the 12th century, the imperial impulse turned anti-colonial, as Irish topography was co-opted as an intellectual bulwark against colonial rule. The political use of Irish topography also finds parallels in contemporary medieval Welsh sources dealing with Ireland. These sources foreshadow British imperialist designs and illustrate how Ireland’s colonial ‘othering’ by its neighbour was articulated through topography. Irish topography was similarly connected to British colonial practices in the 19th century since the modern reception of the topographical literature began as part of an Irish Ordnance Survey project in the 1830s, under the auspices of the military branch of the British Empire. Engagement with places in reaction to major political shifts is not an exclusively medieval phenomenon. Watershed events like Brexit or the war in Ukraine challenge our notion of the immutability of modern European borders and conjure the spectre of imperialism anew. The recent trend which sees Welsh heritage sites adopting their original Welsh names, and the tabling of the question of Irish unity, are different reflexes of the same concern with places among the Irish and British public.

Keywords: medieval ireland,classicism,medieval literature,imperialism,epic,wales,placenames
Scalable Graphene-enabled ElectroChemical Treatment for Complete Destruction of “Forever Chemicals” in Contaminated Water (GRAPHEC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Poly- and perfluoroalkyl substances (PFAS) have been used since the 1940s and are known as “forever chemicals” due to their extreme persistency to advanced (waste)water treatment strategies. Due to the strength of the C-F bond, each released molecule of PFAS remains in the environment. Today there are more than 9,000 known PFAS, majority of them being extremely resistant to any kind of degradation, and with high bioaccumulation potentials and toxicities. Electrochemical processes can address the challenge of PFAS presence in water, provided that the anode material is low cost and can break the C-F bond without forming toxic byproducts. Graphene sponge anode developed by our team is the first material to fulfill both requirements. In this project, we will aim at upscaling the electrochemical treatment based on graphene sponge electrodes and testing its long-term performance in degrading PFAS from complex residual streams. This will enable us to answer key scientific and technical questions required for further technology adoption by the water industry, many of them related to the fundamental mechanisms of electrochemical C-F bond breakage and features of anodically polarized graphene. Based on the results achieved to date at lab-scale, GRAPHEC technology has a strong potential to evolve into a sustainable, chemical-free destruction technology for PFAS-laden wastewaters and achieve their complete destruction at ambient temperature and pressure, in modular units, with low capital and operational cost. Finally, this project also aims at keeping the existing intellectual property and engaging early technology adopters in Europe and beyond to form a mature network of future clients and reach a technology readiness level (TRL) 6 at the end of the project. The project will deliver a new platform technology for the removal of toxic and persistent chemicals from water and is likely to play a key role in the EU´s Green Deal Agenda for securing a toxic-free environment.
Definable Algebraic Topology (DAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 989395.0
EU funding (EUR): 989395.0
Participants: 1
Project status: SIGNED

This project addresses fundamental issues in the development of algebraic topology, coarse geometry, and other areas of mathematics, related to the problem of doing algebra when the structures under considerations also have a topology. A number of other approaches have been proposed recently, showing the current importance of these issues for the mathematical community. The approach followed in this project is unique, in harnessing powerful tools from mathematical logic, and especially descriptive set theory. The fundamental idea is to enrich an algebraic object with additional information provided by a Polish cover, which is an explicit presentation of the given object as a suitable quotient of a structure endowed with a compatible Polish topology. The goal of this project is to show that fundamental invariants from homological algebra, algebraic topology, operator algebras, and coarse geometry, such as Ext, Cech cohomology, KK-theory, and coarse K-homology, can be seen as functors to the category of groups with a Polish cover. Furthermore, doing so provides invariants that are finer, richer, and more rigid than the purely algebraic ones. These invariants will allow us to tackle classifications problems for topological spaces, coarse spaces, C*-algebras, and maps, that had been so far out of reach. Furthermore, we will use these invariants to calibrate the complexity of such classification problems from the perspective of Borel complexity theory. In turn, this will enable us to isolate complexity-theoretic consequences of the Universal Coefficient Theorem for C*-algebras and of the coarse Baum-Connes Conjecture for coarse spaces, and to construct examples of strong failure of such results. Ultimately, the completion of this project will lead to the development of entirely new fields of research at the interface between logic and other areas of mathematics (algebraic topology, coarse geometry, operator algebras).

Keywords: logic,algebraic topology,operator algebras,coarse geometry,homology,cohomology,polish group,descriptive set theory,homotopy,homotopy equivalence