Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbiome centered prediction and prevention of recurrent infections (OUTSMART-infection)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Antibiotics are a double-edged sword: they help clear the current infection, yet can also select for resistant pathogens, making future infections harder to treat. While treatment guidelines recognize this ‘collateral damage’, we currently lack strategies to predict how treatments affect future recurrence and resistance at the individual patient level. This problem is of particular importance in Urinary Tract Infections (UTIs); affecting the majority of women over their lifetime, UTIs can chronically recur despite antimicrobial treatment. Importantly, UTIs are often self-seeded by strains residing in the gut microbiome, suggesting that the gut microbiome may provide means to predict current and future infections and could possibly even be manipulated to minimize infections. Here, we propose an interdisciplinary approach combining high-throughput phenotyping and genomics of same-patient gut-microbiome and UTI samples with machine-learning analysis of clinical records, towards a “look-ahead” treatment strategy for recurrent infections. First, we will use whole-genome and meta-genome approaches to sensitively detect infecting strains within the patient’s microbiome and develop a gene-based model for the infectivity of strains and thereby for the likely infecting agent and resistance profile of infection. Second, we will use long-read sequencing to map genetic linkage among resistances in each patient’s microbiome, enabling the development of a reinforcement machine-learning model to assign treatments that minimize both the risk of treatment failure and of future resistance. Finally, quantifying in vivo and in vitro the impacts of antibiotic intake on microbiome composition, we will test the feasibility of prescribing antibiotics that manipulate the microbiome in favor of less infectious strains. Together, this unique research-to-clinic data-rich approach will establish the basic foundations for a microbiome-based paradigm of look-ahead treatment strategies.

Keywords: genomics,antibiotics,antibiotic resistance,microbiome,gut microbiome,infections,urinary tract infections,electronic health records,personalized medicine,machine learning,digital health,pathogens,enterobacteriaceae
Generation of tumor neoantigens with photodynamic therapy: a new strategy for anticancer vaccines to fight head and neck cancer (PDT-NEO-immunother)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Immunogenic cell death (ICD) is a regulated cell death that stimulates the immune responses resulting in the establishment of long- term immunological memory. ICD alert the immune system by tumor-associated antigens and tumor neoantigens (i.e., antigenicity) and releasing immunostimulant mediators such as the damage- associated molecular patterns (DAMPs, adjuvanticity). ICD can be efficiently induced by photodynamic therapy (PDT). Our key hypothesis is that PDT based on clinically approved and in-house developed photosensitizers, which are efficient in several murine cancer models, will induce ICD in head and neck squamous cell carcinomas (HNSCCs) which are the fourth most frequent types of cancer in men. Specifically, we aim to demonstrate for the first time that PDT will modulate the immunogenicity of dying HNSCC cells not only by releasing DAMPs but also by increasing antigenicity of dying HNSCC cells by affecting their landscape of antigens. This will lead to the activation of the innate and adaptive immune system and to the improvement of anti-cancer therapy of HNSCC patients. For the study, we will exploit HNSCC cells derived from patients’ biopsies, representing an ideal preclinical model that incorporates heterogeneity of tumors observed in patients. In this way, we will obtain the data required to support future clinical trials based on PDT. Indeed, the ultimate goal of the neoantigen identification is to pave the way for developing patient-specific targeted vaccine therapies.

Keywords: photodynamic therapy neoantigens head and neck cancer immunogenic cell death anticancer therapy ex vivo
Superconducting Parametric Amplifier Receiver Technology for Astronomy and Fundamental Physics Experiments (SPARTAN-FX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2999974.0
EU funding (EUR): 2999974.0
Participants: 1
Project status: SIGNED

The emerging technology of superconducting parametric amplifiers (SPAs) can achieve quantum-limited sensitivity over a broad bandwidth by utilizing the wave-mixing mechanism in a nonlinear transmission medium. They are compact, easy to fabricate with planar circuit technology, have ultra-low heat dissipation, and can be integrated directly with other detector circuits. Their performance surpasses that of the state-of-the-art high electron mobility transistor (HEMT) amplifiers, and they can operate from radio to THz frequencies. Therefore, they have the potential to revolutionize almost every kind of microwave, millimetre (mm), and sub-mm instrumentation, from observational astronomy to fundamental physics experiments such as dark matter searches, quantum information platforms, and neutrino mass determination. In this proposal, I will: 1. Develop practical ultra-broadband quantum amplifiers for deployment to mm/sub-mm/THz astronomical receivers and fundamental physics experiments. 2. Develop novel ultra-compact parametric frequency converters to replace traditional superconductor-insulator-superconductor (SIS) mixers and Schottky local oscillator (LO) technologies, enabling the construction of large pixel-count systems for mm-wave heterodyne receivers such as the Atacama Large Millimetre/sub-mm Array (ALMA) and Event Horizon Telescopes (EHT). 3. Explore high critical temperature superconductors to extend the operation of these parametric devices into higher bath temperatures and frequencies in the supra-THz regime, potentially replacing hot electron bolometer (HEB) mixers and quantum cascade lasers (QCLs). The successful delivery of these outcomes marks a paradigm shift in mm/sub-mm/THz instrumentation, replacing all the core technologies used in this regime with a single integratable SPA technology. This will also have a significant impact on many other fields such as telecommunications, medical applications, and remote sensing, among others.

Keywords: parametric amplifiers,travelling wave,quantum electronics,tunnel junctions,kinetic inductance,thin films,high gap superconductor,high critical temperature,millimetre,sub millimetre,terahertz,dark matter,neutrino mass,quantum information,astronomical detectors,receiver,telescope,event horizon telescope
Certainty in an Uncertain World: A Philosophy of Opinion (A Theory of Opinion)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

This research proposes to examine what comprises 'opinion' in today's world of instantaneous communication. How, might it be said, does thought lapse into opinion? It is an urgent question in a time when the world, with its modes of global interconnection and digital platforms, is so heavily characterized by chaotic political debate and image proliferation. The project aims to develop, by reinterpreting select German scholarship, a philosophical, social and critical theory of what it means to articulate and lay claims of perspective, belief and attitude within the contours of twenty-first century social communication. I will argue that a social ontology of 'opinion' requires two distinct levels of analysis: on the one hand, there is a macro level, whereby the broad contours and determinations of opinion are examined as inherently caught up in what Theodor W. Adorno calls the 'Halbbildung' of industrial culture and the institution of public opinion as a development of modern society. On the other hand, utilizing what G.W.F. Hegel calls 'picture-thinking', there is a micro level, whereby a particular epistemic structure adequate to this social situation emerges with its own patterns and forms of validation adapted to the structures of digital communication technologies. Together, these approaches will comprise a social and philosophical reconstruction of ?opinion? characteristic of social communication today. The project can be situated within social and philosophical context whose line of investigation incorporates the discourses of epistemology, cultural and political theory and intellectual history. By formulating a philosophy of opinion, I aim to provide vital new insight into how and why this distinctive epistemological structure of thought has become ever more pervasive in our 'post-truth' society.

Keywords: public opinion,fake news,social epistemology,digital communication,post truth,ideology,social and political theory,intellectual history,social and political philosophy
Developing novel strategies for CO2 valorisation via the iMmobilization of photosynthetic MIcoorganisms in biocoaTed reactors for photosynthetic pigMENTs production (CO2MMITMENT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

During the CO2MMITMENT project, immobilised photosynthetic microorganisms will use CO2 in biocoated reactors to produce photosynthetic pigments. From a research point of view, four research objectives have been identified: First, the photosynthetic microorganisms will be selected based on their desiccation resistance, ensuring high survival rates within the immobilisation matrix and high levels of pigment production. Second, biodegradable copolymers will be developed as a novel immobilisation matrix. Third, the pigment production will be optimised to ensure high productivity of the biocoatings. Lastly, the process will be scaled up to use novel coated bioreactor configurations. Other objectives are the exchange of knowledge and skills between the ER and the hosts which will be ensured by adequate management and training. The results will be shared open access with the general public, scientists and industry allowing appropriate communication, dissemination and exploitation of the results. The development of these biocoated reactors will allow the ER to participate in the two-way, interdisciplinary knowledge transfer, acquiring new skills in the field of environmental biotechnologies and bioreactor engineering (from the host) and the assessment of polymers (from the secondment), while sharing her knowledge on microbiology and mass spectrometry with the host and the secondment partner. These exchanges will allow her to develop the necessary skills for a successful career in the scientific field, whether in academia or industry. The CO2MMITMENT project will allow the exchange with industrial partners, which could allow future collaborations and lead to innovation and entrepreneurship in the EU. In addition, CO2MMITMENT will commit to open access science, and strengthen the position of the EU in reducing greenhouse gas emissions by 55% by 2030, allowing the Union’s industry leadership in the field and therefore its competitiveness and growth.

Keywords: cell immobilisation,extremophilic microorganisms,pigment production,biocoated reactors,copolymers
clinical validation of Artificial Intelligence for providing a personalized motor clinical profile assessment and rehabilitation of upper limb in children with unilateral Cerebral Palsy (AInCP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Netherlands,Austria,Belgium,Australia,Georgia
Call: Clinical validation of artificial intelligence (AI) solutions for treatment and care (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 6494092.5
EU funding (EUR): 6494092.0
Participants: 12
Project status: SIGNED

Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system. AInCP aims to develop evidence-based clinical Decision Support Tools (DST) for personalized functional diagnosis, Upper Limb (UpL) assessment and home-based intervention for children with UCP, by developing, testing and validating trustworthy Artificial Intelligence (AI) and cost-effective strategies. The AInCP approach will: i) establish a clinical diagnosis and accurate prognosis for treatment response of individual UCP profiles, by employing a multimodal approach including clinical phenotyping, advanced brain imaging and real-life monitoring of UpL function, and ii) provide personalized home-based treatment, from advanced ICT and AI technologies. The AInCP will build upon personalized diagnostic and rehabilitative DST (dDST and rDST) to be developed and validated through large observational and rehabilitation studies, including at least 200 and 150 children with UCP, respectively. Using data driven and AI approach, dDST and rDST will be combined for developing a theranostic DST (tDST) that will allow the re-designing of an economical, ethical, sustainable decision-making process for delivering a personalized and validated approach, focused on the care, monitoring and rehabilitation of UpL in children with UCP. AInCP is a significant example of a transdisciplinary approach, where all project collaborators (clinicians, data scientists, physicists, engineers, economists, ethicists, SMEs, children and parent associations) will work closely together in building the AInCP approach. This approach will, therefore, hinge on transdisciplinary contributions, multi-dimensional data, sets of innovative devices and fair AI-based algorithms, clinically effective and able to reduce users? and market barriers of acceptability, reimbursability and adoption of the proposed solution.

Keywords: cerebral palsy,paediatric stroke,predictive biomarkers,telerehabilitation,brain structure,upper limb assessment,upper limb rehabilitation,machine learning,data science
MARPERWISE: Submarine permafrost and seafloor geomorphic change in the Canadian Beaufort Sea (MARPERWISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Malta,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-07
End date: 2028-01-06
Duration (months): 36.0
Total project cost (EUR): 259429.92
EU funding (EUR): 259429.92
Participants: 4
Project status: SIGNED

Submarine permafrost, a vital component of the Arctic environment, plays a significant role in geological and environmental processes. However, critical knowledge gaps persist, necessitating comprehensive investigations. Our project, 'MANPERWISE,' seeks to address these gaps and enhance our understanding of this dynamic phenomenon. Despite advancements, uncertainties surround the extent, thickness, and degradation of submarine permafrost in the Arctic. 'MANPERWISE' aims to quantify these aspects within a designated study area, employing a state-of-the-art controlled-source electromagnetic (CSEM) system developed by the University of Malta. One key objective is to unravel the intricate relationship between permafrost degradation and seafloor geomorphic changes, with a specific focus on seafloor instability. By analysing data acquired through our CSEM system and comparing it with seafloor morphology, we aim to elucidate the mechanisms driving these transformations. Furthermore, 'MANPERWISE' envisions the development of a conceptual design for a Remotely Operated Vehicle (ROV)-based or Autonomous Underwater Vehicles (AUVs)-based CSEM instrument. This advanced tool will enable high-resolution, repeat mapping of submarine permafrost and Submarine Groundwater Discharge (SGD). Such innovation promises transformative insights into the Arctic's evolving dynamics. Dissemination efforts encompass scientific publications, research conferences, seminars, a dedicated project website, and engagement with policy-makers and the general public. Guided by Prof. Charles K. Paull (MBARI), Prof. Aaron Micallef (University of Malta), and Prof. Mark Everett (Texas A&M University), ‘MANPERWISE’ addresses critical knowledge gaps in submarine permafrost dynamics, offering insights with implications that extend beyond the Arctic region to global climate processes.

Keywords: marine science,seafloor exploration,permafrost dynamics,climate change mechanisms,geophysical surveys,csem technology,hydrogeological processes,arctic environment,subseafloor mapping
Developing an inductive spectrometer for electron paramagnetic resonance detection and imaging at the micron scale using superconducting quantum circuits. (INDIGO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1992500.0
EU funding (EUR): 1992500.0
Participants: 1
Project status: SIGNED

Electron paramagnetic resonance (EPR) is a powerful spectroscopy method which allows to identify paramagnetic species and quantify their interactions with their environment. Because of the weak spin-microwave coupling, conventional EPR spectroscopy has a low sensitivity which limits its use to samples of macroscopic size. Recent experiments demonstrated that superconducting quantum circuits have the potential to drastically enhance the spin detection sensitivity down to the detection of ~10 spins within 5 fL. However, these demonstrations have so far been done using well-known model spin systems and in restrictive conditions: very narrow spin and detector linewidths, extremely low microwave losses, and low static magnetic fields. They are thus incompatible with modus operandi that are typical in EPR spectroscopy: probing aqueous or non-crystalline samples, applying strong magnetic fields, or studying species with short coherence lifetimes or spin-spin interactions which require large excitation bandwidth. The restrictive conditions of these proof-of-concepts are however not a prerequisite for achieving high-sensitivity EPR detection. Using recent advances made in the fabrication process and in the design of quantum circuits, I propose to lift these restrictions and build a quantum-circuit based EPR spectrometer able to probe a large scope of spin species and to detect, characterize and image EPR signals in micron-sized samples. We will meet this goal by 1) developing a resilient high-sensitivity spectrometer able to probe spins with short coherence times and characterize spin-spin interactions; 2) implementing imaging techniques with sub-micron resolution; and 3) benchmarking our spectrometer for typical volume-limited applications. Our EPR spectrometer will open interesting research paths in biology chemistry or condensed matter, for instance by allowing to detect EPR signals in single cells, micro-protein crystals or from organic semiconductors.

Keywords: electron spin resonance high sensitivity detection and imaging quantum circuits technologies application to biology and chemistry