Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Origins and evolution of programmed cell death machinery during the emergence of animal multicellularity (HoloCellDeath)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Programmed cell death (PCD) is an essential function in multicellular organisms; it regulates normal development, responses to cell damage, and cell turnover. Accordingly, the PCD machinery present in the unicellular ancestors of animals was likely critical to the emergence of the complex multicellularity found in extant animals. However, we lack a full understanding of the PCD repertoire in the unicellular relatives of animals, and whether that ancestral repertoire underwent significant changes at the onset of Metazoa To fill this gap in our understanding we will perform a comparative genomics approach, combined with in vivo experiments, to examine the distribution and evolution of programmed cell death (PCD) proteins in the unicellular relatives of animals. This will identify which components of the PCD machinery were already present in the unicellular ancestor of animals, and the functional and regulatory changes that they might have undergone, and which led to the emergence of apoptosis in animals. Of particular interest is the subtype of PCD known as apoptosis, as the most characteristic apoptosis proteins are thought to be animal-specific. To investigate whether functional modifications occurred in the PCD repertoire at the origin of animals, we will perform in vivo experiments in two unicellular relatives of animals, Capsaspora and Creolimax, for which the host lab has developed transformation protocols. We will overexpress, and if possible silence, candidate pro- and anti-apoptotic proteins in those taxa to test whether they induce or protect against cell death. We will also examine protein interactions of these proteins during a proposed secondment. This project will provide the first comprehensive reconstruction of programmed cell death machinery across the group comprising animals and their unicellular relatives. The findings will be of interest not only to evolutionary biologists, but also to microbiologists, and to cell and developmental biologists.

Keywords: eukaryotic evolution,holozoa,unicellular holozoans,protists
The unique dioxygenases of phytophagous spider mites: new enzyme players in plant-herbivore interactions? (DOGMITE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Detoxification of poisonous xenobiotics in animals is typically performed by multi-gene enzyme families. Within arthropods, only insect genomes have been studied in detail where these families are well characterized. I recently uncovered a new enzyme family in the genome of a non-insect arthropod, the extremely polyphagous plant-feeding mite Tetranychus urticae and showed that this proliferated family was acquired via horizontal gene transfer from a fungal donor. The family codes for intradiol ring cleaving dioxygenases which cleave a particular set of aromatic structures, commonly found in pesticides and plant metabolites. Here, I propose to functionally characterize this exciting new gene family and to elucidate its role in xenobiotic detoxification, with a focus on plant secondary metabolites. First, to create a general picture, I will map the in situ expression of dioxygenases and time their responses to plant-derived secondary defense metabolites. Second, guided by preliminary results, I plan to study how these new herbivore enzymes counteract polyphenol oxidases, well-known plant defense enzymes that act against herbivores and target the same class of substrates. State-of-the-art plant transformation experiments will be performed in order to meticulously dissect their counterplay. Finally, by means of an unbiased multi-layered strategy, I will functionally characterize these new dioxygenases. Dioxygenases will be introduced into biological systems by functional expression in E. coli or insect cells, and by genetically transforming Drosophila. Cutting-edge differential metabolomics will identify the substrates and reaction products. By means of this project, I expect to unravel the selective advantage of this new family for phytophagous mites and open up avenues to exciting biotechnological applications which I expect to extend well beyond agriculture.

Keywords: mites,xenobiotic metabolism,tomato defenses,phytophagy,arthropod physiology,herbivore plant interactions
Innovation support through specialized EEN services for Walloon innovative SMEs 2019 (Kamwal 2.3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium,Belgium,Belgium,Belgium,Belgium,Belgium,Belgium,Belgium
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 66050.0
EU funding (EUR): 66050.0
Participants: 10
Project status: CLOSED

The Kamwal 2.3 project aims to propose specialized innovation support services to Walloon SMEs through the Enterprise Europe Network during the year 2019. The goal of these services is to help SMEs having already a clear growth and internationalization potential to grow more rapidly. The proposed innovation services are twofold. A service of dedicated coaching (KAM service) will be proposed to the beneficiaries of the SME Instrument, FTI or FTE-open programme. This service starts by an assessment of the SME lacks and coaching needs by specialized consultants . It continues by the identification of external coaches. These coach will work with the company with the support of the EEN team and services. It is expected that the project will have the opportunity to serve 3 Walloon Ibeneficiaries. SMEs not involved at that time in the SME instrument but having also a clear potential could benefit from the EIMC service which aims to help them to improve the management of innovation processes. This will be achieved through specific tools, INNONET developed by Innovatech or IMPROVE both compliant with the CEN/TS 16555-1. It is expected that a set of 10 promising Walloon SMEs benefit from this specialized service. Both services will be operated by a team of experienced consultants coming from Innovatech, as partner of the Entreprise Europe Network Wallonia and as specialist of innovation support to SMEs.

Keywords: innovation management,enterprise europe network,sme instrument,coaching,fet open
Industrial scale-up of a novel and disruptive microalgae photobioreactor (BREVEL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-02-01
End date: 2022-10-31
Duration (months): 33.0
Total project cost (EUR): 1675890.0
EU funding (EUR): 1173123.0
Participants: 1
Project status: CLOSED

Brevel developed a disruptive microalgae cultivation technology which dramatically reduces the cultivation costs for light-dependent microalgae and enables penetration into new and yet untapped markets where microalgae biomass and derived products are much desired. The technology is based on shifting from very large, relatively inefficient and labour-intensive outdoor cultivation system to completely closed, sterile and fully automated indoor photobioreactors which are efficiently illuminated from within and are capable of continuous mixotrophic cultivation which combines photosynthesis with fermentation processes. The patented Brevel mixotrophic cultivation technology has been successfully demonstrated on a large scale with surprising results of more than 90% cost reduction and up to 200 higher yields per land compared to current outdoor state-of-the-art photobioreactors. Conditions are finally ripe for the next big stage of mass production. Capitalizing on the technological advancement, a first pilot factory capable of producing 400 tonnes of biomass annually will be constructed and the first use case of salmon feed supplements will be addressed to replace the current unsustainable synthetic alternative at comparable costs. Next, additional markets including protein and fatty acids from a sustainable source at affordable costs will be approached.

Keywords: microalgae,photobioreactor,astaxanthin,mixotrophy
Magnetic Nanohybrids for Cancer Therapy (MaNaCa)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Armenia,Greece,Luxembourg
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 798112.5
EU funding (EUR): 798112.5
Participants: 4
Project status: CLOSED

The MaNaCa project intends to develop the scientific and technological capacity as well as raising the research profile of the Institute for Physical Research of the National Academy of Sciences (IPR-NAS) in Armenia. From a scientific standpoint, MaNaCa will focus on the structural and magnetic characterization of magnetic nanohybrids and their application for cancer therapy. The project's aim will be accomplished by networking IPR-NAS with two internationally-leading research organisations: the Aristotle University of Thessaloniki (AUTH) in Greece and the University of Duisburg – Essen (UDE) in Germany. Throughout the project, the research partners will be supported for management ad dissemination by Intelligentsia Consultants Sàrl (INT), a consultancy company based in Luxembourg which has already collaborated on several occasions with the Widening partner. During the project, which will have a total duration of three years, the partners will carry out a research and innovation strategy with these objectives: 1. Stimulating scientific excellence and innovation capacity of IPR-NAS with regard to magnetic nanohybrids for cancer therapy. 2. Improve the career prospects of early stage researchers of IPR-NAS and the Twinning partners 3. Raise the research profile of IPR-NAS and the Twinning Partners In order to accomplish this task, the consortium partners will implement several actions through the project’s work packages: (WP1) exchange of senior researchers; (WP2) exchange of early stage researchers; and (WP3) dissemination and oureach. Project management (WP4) will be coordinated by IPR-NAS with the support of INT. In addition to staff exchanges, project's activities will include technical training, joint publications, joint participation to conferences, organization of summer schools, workshops and an international conference.

Keywords: core shell magnetic nanoparticles,nanostructured coatings,magnetic nanohybrids characterization,magnetic particle hyperthermia,cancer nanotechnology,drug delivery systems
A novel in-vitro diagnostic test for drug-resistant tuberculosis and a personalized antibiotic treatment plan. (Tuberculini)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Company: Clemedi AG is a Swiss SME, founded in 2019 as a spin-off from the University of Zurich, with the aim to develop in vitro diagnostic (IVD) tests for antibiotic resistance and susceptibility in infectious diseases. The vision of Clemedi is to support the global battle against antibiotic resistance by developing IVDs that will allow personalized prescription of antibiotics. Need to address: Antimicrobial resistant infections will be among the world’s leading causes of death by 2050. Multi-drug-resistant tuberculosis (MDR-TB) is a large contributor to death by antimicrobial resistance, with over 240k global mortalities (of which 10k in Europe) per year. Many of these are caused by the inability to detect resistance and antibiotic susceptibility in the diagnostic process. Solution: Clemedi is developing a unique platform to rapidly diagnose drug-resistant infectious diseases, including MDR-TB, and rapidly provide a matching therapy plan. The platform uses proprietary primers to amplify specific DNA from patient samples, followed by next-generation sequencing (NGS) analysis. Machine-learning algorithms are then used to annotate the NGS data, and determine susceptibility or resistance based on DNA-profiles to provide a focused advice on antibiotic therapy, within 24-48 hours after obtaining a patient’s sample. Business opportunity: The minimum total addressable market for Clemedi (i.e. every person that needs to be diagnosed for MDR-TB) is valued at €73.7 M. Competitors are companies that also develop IVDs for rapid detection of MDR-TB, such as Hain Lifescience, Cepheid and Becton-Dickinson. The main competitive advantage of Tuberculini is its ability to analyze susceptibility for a significantly larger number of antibiotics (12 vs. 1-5). Only this can positively impact disease management. Feasibility study: Financial support from the SMEi P1 will be used to assess the technical and commercial feasibility of Tuberculini, Clemedi’s IVD for MDR-TB.

Keywords: multi drug resistant tuberculosis,mdr tb,antimicrobial resistance,in vitro diagnostic,machine learning,therapy prediction,tuberculosis,next generation sequencing
Classical Levitonics: transposing quantum levitons to classical waves for single side band wireless data transmissions (C-Levitonics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-12-01
End date: 2017-05-31
Duration (months): 18.0
Total project cost (EUR): 149404.0
EU funding (EUR): 149404.0
Participants: 1
Project status: CLOSED

The project addresses the field of wireless digital communication. This field has constantly grown during the last twenty years with the development of cell phones and WiFi Local Area Network and with the development of digital TV broadcasting and satellite communications. A second expansion of digital communications has recently started with networks of objects: Bluetooth smart devices are available to consumers and RFID devices are used for object tagging, security identification and health sensors. Connecting devices will lead in a very near future to the Internet of Things. Digital communications form a huge market of 100 billion of transceivers connecting humans and devices. Any technological improvement is expected to generate important economic benefits. This is the aim of C-Levitonics. To physically encode binary information, wireless, optical fiber or copper wire data transmissions are based on the modulation of the phase or the amplitude of an electromagnetic wave, called carrier wave. A new waveform for the phase modulation associated with an elementary symbol (or bit) is proposed. It derives from a direct application to classical physics of the recently discovered levitons in quantum physics, a by-product of a former ERC AdG MeQuaNO project. The new modulation, called Single Side Band Phase Shift Keying (SSB-PSK), provides attractive spectral properties: single side band (SSB) spectrum (highly desired feature in optical or radio communications) and reduced frequency bandwidth allowing more users in a frequency range. Totally new (patent pending) SSB-PSK can operate using existing digital communication technology. A convincing demonstrator based on software radio technology will be delivered. In parallel a market prospective will identify the best markets and the technical specifications adjusted to them. At the end of the C-Levitonics project a start-up will be created providing development, consulting services and licensed technology transfer.

Keywords: information and communication technology,digital communication,wireless data transmission,phase shift keying,frequency shift keying,single side band,phase modulation
Therapeutic approaches to enhance innate immunity against Tumors (TNT-TUMORS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2499646.0
EU funding (EUR): 2499646.0
Participants: 1
Project status: CLOSED

Recent advances using immune checkpoint inhibitors demonstrate the great potential of immunemodulation in cancer and metastasis treatment. However, the effective treatment of only a subset of patients shows that this is only the start to utilize the power of the immune system to fight cancer. An interesting approach is to harness innate immune cells, such as plasmacytoid dendritic cells (pDCs) and tumor-associated macrophages (TAM) to attack tumors and to enhance the effect of standard anti-cancer therapies. Recently, using mouse models we identified two independent mechanisms by which modulation of these two cell types restrained tumor growth. First, the direct killing of tumor cells by pDCs that occurs independent of the adaptive immune system. Second, we identified a tumor-promoting role of EGFR-expressing (EGFR+) TAMs during tumorigenesis. This enables us to look at the role of EGFR in tumorigenesis in a completely new way and we plan to exploit this novel finding to reevaluate the mechanism by which anti-EGFR drugs are effective in tumors. The mechanisms endowing pDCs with tumor-killing capacities and determining the specificity of tumor cell recognition by activated pDCs are poorly understood. Furthermore, the interaction of pDCs with macrophages has never been investigated in tumors. Here I propose to define the molecular mechanisms by which pDCs and TAMs can be instructed to adopt an anti-tumorigenic phenotype. Inducible and cell-specific genetic mouse models mimicking human cancers will allow to molecularly dissect the immunemodulatory capacity of pDCs and TAMs. State-of-the-art large scale in vitro and in vivo RNAi screens will provide a platform to identify novel molecular pathways and open the possibility for testing new strategies in cancer immunetherapy. The clinical significance of our findings will be validated in human cancer samples in close cooperation with clinicians, which ensures a fast predictive and therapeutic translation of our results.
Enabling Crowd-sourcing based privacy protection for smartphone applications, websites and Internet of Things deployments (PRIVACY FLAG)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Italy,Greece,Sweden,Greece,Switzerland,Greece,Serbia,United Kingdom,Luxembourg,Denmark,United Kingdom
Call: Privacy (H2020-DS-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-05-31
Duration (months): 37.0
Total project cost (EUR): 4538437.5
EU funding (EUR): 3142999.75
Participants: 13
Project status: CLOSED

Privacy Flag combines crowd sourcing, ICT technology and legal expertise to protect citizen privacy when visiting websites, using smart-phone applications, or living in a smart city. It will enable citizens to monitor and control their privacy with a user friendly solution provided as a smart phone application, a web browser add-on and a public website. It will: 1.Develop a highly scalable privacy monitoring and protection solution with: - Crowd sourcing mechanisms to identify, monitor and assess privacy-related risks; - Privacy monitoring agents to identify suspicious activities and applications; - Universal Privacy Risk Area Assessment Tool and methodology tailored on European norms on personal data protection; - Personal Data Valuation mechanism; - Privacy enablers against traffic monitoring and finger printing; - User friendly interface informing on the privacy risks when using an application or website. 2.Develop a global knowledge database of identified privacy risks, together with online services to support companies and other stakeholders in becoming privacy-friendly, including: - In-depth privacy risk analytical tool and services; - Voluntary legally binding mechanism for companies located outside Europe to align with and abide to European standards in terms of personal data protection; - Services for companies interested in being privacy friendly; - Labelling and certification process. 3.Collaborate with standardization bodies and actively disseminate towards the public and specialized communities, such as ICT lawyers, policy makers and academics. 11 European partners, including SMEs and a large telco operator, bring their complementary technical, legal, societal and business expertise; strong links with standardization bodies and international fora; and outcomes from over 20 related research projects. It will build a privacy defenders community and will establish a legal entity with a sound business plan to ensure longterm sustainability and growth.

Keywords: crowd sourcing,smart city,personal data protection,regulation,legal aspects