Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Single cell RNA-seq analysis of individual sperm cells to identify transcriptomic differences potentially involved in preferential fertilization. (SAMEorNOT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: CLOSED

Human societies are sustained by flowering plants in different ways but especially as a key food supplier. However, it is known that increasing global temperatures strongly affect plant reproduction and the growing human population will require more food in short-middle term. Thus, to create new crop varieties more resistant to heat stress and with enhanced yield, a deeper understanding of the mechanism of plant sexual reproduction will be crucial for increasing the efficiency of plant breeding programs. Plant reproduction relies on a double fertilization process, in which two sperm cells from a pollen grain reach the ovule and one fertilize the egg cell while the other the central cell. In some species with dimorphic sperm cells a preferential fertilization of each sperm cell has been described, but for Arabidopsis thaliana as well as for many economically important crops with isomorphic sperm cells this question remains unclear. The main goal of this project is to identify by single cell RNA-seq analysis potential transcriptomic differences between the two Arabidopsis sperm cells. To do that, individual sperm cells from pollen tubes growing through female stylar transmitting tissue (semi in vivo) will be isolated by micromanipulation using a specially designed microfluidic chamber on an inverted microscope. The identification of differentially expressed genes would enable for the first time the creation of a sperm single-cell marker line to eventually explore a hypothetical preferential fertilization in Arabidopsis. These results can be adapted for plant breeding programs to develop impactful biotechnological tools, like haploid inducer lines with genetically modified sperm cells to specifically deliver components in the egg cell to induce in vivo gynogenesis. Additionally, the results will be a valuable scientific resource to address other topics beyond the preferential fertilization, like exploring hybridization barriers based on gamete recognition.

Keywords: plant reproduction,pollen,sperm cells
Magnon-Phonon Interactions in Finite Temperatures (MagPhoni)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

A fundamental problem in many-body physics is the behaviour of collective degrees of freedom (DOF) in finite temperatures. The ubiquitous quasiparticle paradigm – phonons for vibrational DOF and magnons for magnetic DOF - linearizes the theory to arrive at an independent particle description. That this picture fails in finite temperatures is well-known and is usually addressed through a perturbative approach, supplementing the ideal plane waves with magnon-magnon and phonon-phonon scattering. Similarly, spin-lattice coupling can also compromise the validity of the phonon and magnon pictures. Spin-lattice interaction has recently attracted increased experimental and theoretical attention, given its potential significance in many subfields of material science, such as spin-thermoelectrics and spintronics. Still, most treatments remain perturbative, offering only renormalized resonances and finite excitation lifetimes. The inadequacy of such a description is immediately apparent for paramagnetism, or structural phase transitions, where the original ordered ground state of the quasiparticle is gone. This study sets out to establish a new conceptual framework for measuring and evaluating magnon-phonon interactions in crystals, adopting a phenomenological self-energy description which makes no assumptions about the magnitude of the effect. We will model the effect using many-body Green's functions to parameterize the excitation's correlation function and map the interaction into the diffuse X-ray pattern of archetypical systems (Fe, MnO, Co). Next, we will apply the generalized scheme to measure magnetic excitations in metal-organic frameworks inaccessible by traditional probes. Finally, I will explore the existence of paramagnons and magnetic phase transition above the Néel temperature. All three avenues, realized under a shared scheme, offer insight into a new unified phenomenological theory for vibrational-magnetic excitations in finite temperatures.

Keywords: magnons phonons anharmonicity many body green s functions
Real-time measurements of oceanic waves using connected buoys and mobile stations (REALTIMESEA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France,Ireland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-05-01
End date: 2024-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The ERC Advanced Grant HIGHWAVE is a current project that studies the physical mechanisms underlying the emergence of destructive breaking waves on the ocean’s surface. The recent months have shown the multiplication of abnormal atmospheric disturbances generating extreme winds and waves that surprised forecasters. It is therefore essential to be able to extract useful information from real-time measurements of winds and waves. In planning to address this problem from a science perspective, we discovered a critical gap in all current approaches to ocean wave measurements and maritime communications. There is no existing technology that provides air and water information (wave amplitude and direction, wind speed and direction, current speed and direction) of any given sea state in real time. The lack of any technique providing instant access to a sea state makes it extremely difficult to adapt to a changing sea state and to act fast. REALTIMESEA will fill this gap, using wireless wave sensor technology deployed on a connected buoy to measure and transmit instantaneously to a fully equipped mobile station the raw data of the sea state (air and water) at a given location at a very low communication cost. Considering that our idea can be extended to a linked network of connected buoys, thus adding a spatial component to the real-time measurements, one can say that the ability to track sea states in real time and space will represent a revolution in wave forecasting, with expected commercial applications for multiple “end users”. Taking the real-time measurement of waves to Proof of Concept is made possible because of the recent development of maritime wireless networks, that enables Wi-Fi data coverage over large areas of water within a 12 km radius from a shore station. A 1-year campaign off Inishmaan, Ireland, will allow the optimisation of the measurement system, the development of the required analysis software and of the manual for the buoy/mobile station kit.
Anticipate disease outbreaks in fish farming (KOA)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-12-15
End date: 2024-10-14
Duration (months): 10.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

With a growing demand for protein sources, aquaculture is postulated as a sustainable solution to meet this market need. However, fish farms are facing serious problems of fish mortality and/or the need to treat diseases with antibiotics, as there is a lack of technological solutions to anticipate the appearance of infectious pathogens. Among the different sectors that suffer from this problem, aquaculture is the vertical whose market is estimated to have the greatest growth potential (within the food industry), regardless its little technological development. Current solutions in the market cannot detect pathogens on-site in a continuously and autonomous manner, without giving farmers the chance to prevent undesired bacterial growth, lowering down reaction times. As a result of this lack of capacity to anticipate pathogen infections, aquaculture companies face the following problems: 1. Unwanted fish mortality, due to late diagnosis of infections. 2. The need to use antibiotics, decreasing the quality of the product produced and increasing the environmental impact. 3. Increased production costs due to low productivity and increased technical costs associated with sanitary controls and treatments. 4. Sustainability problems caused by the generation of food waste, loss of animal welfare and the use of chemical products that are harmful to the environment. All these problemas resut in economic cost of 6 B$/year and losses of between 20% and 30% of production . In response to these problems, KOA was founded, with the aim to develop an integral device that autonomously monitors pathogen concentrations in fish tanks and keep track of its evolution over time, leading to relevant economic and production savings.

Keywords: biosensing,disease monitoring,aquaculture,iot
SuperScienceMe - RESearch is your RE-Source (SUPERSCIENCEME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 6
Project status: CLOSED

Research requires original ideas, freedom, rigor, discipline and continuous study; it requires knowing how to pursue goals, accepting failures and frustrations, and fully enjoying gratifications and satisfactions. Research gives unique opportunities and Hope to the world, especially to the new generations, inspires people to get involved, to believe in and gamble on themselves. This is the message Giorgio Parisi, fresh Nobel Prize in physics, delivers to the world on the day of the awarding of the most important prize for a scientist; and this is the message that superheroine SuperScienceMe makes its own for the new edition of the European Researchers’ Night. Researchers are like curious children, whose attention is inexorably attracted by the charm of nature; they are inebriate by so much beauty, then ask questions and seek for answers, they study tirelessly, attempting to unveil the secrets of the Universe. SuperScienceMe aims at spreading this message to children, young people, men, women and families, in a historical moment in which people are bewildered, facing challenges that seem insurmountable for mankind. Only science can help humanity to reach the summit and to scan the horizon of the future with hope. For this noble purpose, SuperScienceMe asks for help from one of the greatest scientists that history can remember: Leonardo da Vinci. The Italian genius will accompany SuperScienceMe and modern scientists on a wonderful journey among the people, to tell them the exciting fairy tale of science. In line with the main scope of the MSCA-CITIZENS action, the project “SuperScienceMe - RESearch is your RE-Source” builds a symbolic bridge that connects past and future by passing through the present and gets researchers closer to the general public encouraging at the same time the youth, especially the women, to embark on scientific careers, thus driving everyone’s effort towards a more equitable, green, resilient and healthy Europe.

Keywords: schools,teachers,science literacy,european missions,sustainability,social inclusion,rri,science dissemination,enjoying research,steam,gender,msca fellow
Coding for DNA Storage (DNAStorage)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1999096.0
EU funding (EUR): 1999096.0
Participants: 1
Project status: SIGNED

DNA-based storage has attracted significant attention due to recent demonstrations of the viability of storing information in macromolecules. Unlike classical optical and magnetic storage technologies, DNA-based storage does not require electrical supply to maintain data integrity, and given the trends in cost decreases of DNA synthesis and sequencing, it is estimated that within the next decade DNA storage may become a highly competitive archiving technology. However, existing coding solutions to address various problems associated with implementations of DNA-based storage systems are very limited in their development. The goal of this research is to develop coding methods and techniques by designing novel and advanced solutions that are specifically targeted for the unique structure and error behavior of DNA-based storage systems. The proposed analytical framework will allow to address coding-theoretic challenges arising in the context of synthesis, storage, and sequencing of DNA strands. To achieve these goals, we aim to design codes for clustering, trace-reconstruction techniques, error-correction codes, and constrained codes. These codes are applicable for long-term storage and recovery of data recorded in DNA, while overcoming the unique challenges associated with the DNA storage channel. We expect that knowledge, techniques, and qualitative insights gained in our investigation will advance DNA storage technologies capable of accommodating the massive amounts of data. Furthermore, solving the proposed coding problems will require new methods and ideas that will also impact adjacent scientific disciplines such as bioinformatics, combinatorics, and theoretical computer science. Thus, the proposed investigation is likely to lead to the development of new paradigms and directions of research that may have far-reaching societal and economic impact. Lastly, the accompanying experimental testing will allow for practical as assessments of system performance and cost.

Keywords: coding theory,error correcting codes,constrained codes
Fostering Participation Action Research to Develop Online Bereavement Support Application to support Bereaved Parents after a Traumatic Death of Their Child. (PCARE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-07
End date: 2024-09-06
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

"After a homicide, suicide, malpractice, or death of a child, there can be terribly deep bitterness and anger at the perpetrator, making the grieving unable to move forward in life when death cannot be accepted" (Anna Liisa Aho, 2020). Among all events leading to bereavement, the death of a child is categorized as the most devastating event, leaving bereaved parents with effects on their health, psychology, and social relationships. To date, there is a lack of understanding regarding parental grief after the traumatic death of a child. A discussion on bereavement after a traumatic death may be taboo, and its need is underestimated due to culture and beliefs among people. The proposed study aims to investigate bereaved parents` meaning-making process after the traumatic death of their child, analyze the dynamic of formal and informal support received by the bereaved parents, analyze formal supports from bereavement experts` perspectives, and develop a web-enabled app-based intervention (PCARE app) that is derived from bereaved parents` and bereavement experts` perspectives to support bereaved parents. This study combines various qualitative research approaches, including in-depth interviews, Focused group discussion, and Participatory Action Research. The participants will be bereaved parents who experienced the traumatic death, bereavement experts, and IT professionals. Thematic analysis using ATLAS ti. software will be conducted to identify themes that emerge from the study. The themes will be translated into the innovation of the PCARE app. This study is vital to support the United Nations' sustainable goals and Horizon Europe's strategic planning to strengthen the health care systems and promote vulnerable families' health and well-being outcomes through the innovation of bereavement digital-based intervention.

Keywords: parental grief,traumatic death,meaning making,support,participatory action research,qualitative studies,online bereavement support
Repod: Revolutionising Waste Management with AI-Powered Precision Sorting and Circular Economy Solutions. From waste to secondary raw materials on site. Shortening the waste management chain. (Repod)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Repod revolutionizes waste management with advanced technology. Our device recognizes, sorts, shreds, and seals waste into compostable pods. Real-time data collection via our online dashboard provides insights on materials processed, converting waste into secondary raw materials (SRM) for the circular economy. This reduces environmental footprints and creates revenue streams for users, who can cut waste taxes by selling SRM back to Repod. Using AI, machine learning, and spectrometry, our device achieves precise material sorting. The online platform aids smart fleet management, optimizing SRM collection and reducing costs. The global waste management market will reach $530 billion (€470 billion) by 2025. Repod targets private citizens, food and beverage companies, hospitality sectors, condominiums, yachting, harbors, airports, and public parks. TAM is €670 billion, SAM is €350 billion, and SOM is €34 billion. Our revenue model includes collecting/reselling SRM, selling hardware/software, consumables, and data, promoting sustainable waste management. Repod's technology reduces landfill use, emissions, primary material extraction, incineration, waste-to-energy processes, truck fleet impacts, littering, and mismanagement. It supports job creation and a circular economy. Our team includes experts in robotics, waste management, data analytics, electronic engineering, marketing strategy, environmental engineering, LCA specialization, a serial entrepreneur, an innovation strategist, and startup, finance, and business model strategists. Our advisory board provides strategic guidance. Repod has raised funds through two investment rounds and four public grants. With our prototype ready for market, we project revenue growth in five years, achieving profitability by year three. Continued R&D investment and enlarging our patent portfolio will ensure Repod's innovation leadership in waste management.

Keywords: ai powered waste management,precision sorting,circular economy,srm,sustainable waste processing,real time data,smart fleet management,environmental impact reduction,secondary raw materials
Uncovering the coevolution between microbial predators and prey (CO-PP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2269196.0
EU funding (EUR): 2269196.0
Participants: 1
Project status: SIGNED

Predation plays a key role in the planet’s ecology and evolution. The most prevalent and diverse predators on the planet are protozoans, single-cell eukaryotes that live from consuming bacterial prey. Protozoan predation massively impacts bacterial diversity, shapes microbial ecosystems, is essential for nutrient cycling and has been linked to the emergence of bacterial virulence. Yet, despite its importance, it remains largely elusive how protozoan predators and bacterial prey coevolve. To understand this coevolution, we need an integrative research approach that accounts for offense and defense mechanisms in both predator and prey, and spans from cellular response systems to community ecology. Here, I take this approach, and present the first integrative research program on microbial predator-prey coevolution. By leveraging recent advances in gene editing and single-cell phenotyping, we will focus on the coevolution between amoebal predators and bacterial prey in the soil – a hotspot for microbial predation. First, we will establish a predator-prey model system that permits a two-sided and systems-level analysis of predation. Using genome-wide genetic screens, we will identify all genes underlying offense and defense mechanisms, study how they exert their effect, how they are regulated, and how they impact selection across environments. Second, we will expand from our model system, to study natural predator-prey soil communities. We will explore how sexual reproduction and horizontal gene transfer impact coevolution, and emulate soil conditions in the lab, to determine how biotic and abiotic factors affect eco-evolutionary dynamics of predator-prey communities in both time and space. My research will connect ecology and evolution with molecular and systems biology, opening up the door for breakthrough advances in our understanding of predator-prey interfaces, the impact of coevolution on microbial ecosystems, and the emergence of nascent pathogenicity.