Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel dual fuel system for diesel locomotive modernisation to CNG or LNG operation (DiGas Dual fuel)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Latvia
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Company is developing proprietary state-of-the-art dual fuel technology and has designed low-cost, scalable, installable at minimum cost and lead time dual fuel system tailored for locomotive sector. The project will accelerate diesel locomotive market transition from oil based diesel fuel to cheaper, cleaner and much more sustainable alternative and bio fuel - methane either in form of Liquefied (LNG) or Compressed (CNG) methane. Switching the fuel enables locomotive sector to strengthen the advantage railroads hold over trucks in long-haul shipping, comply with tougher environmental and exhaust standards and decrease fuel costs in the same time. In recent years methane is getting a high attention from transport companies, investors, and government in rail sector with US leading the market development. Opportunity is being seized by GE, CAT, EMD and few smaller companies by piloting and testing their dual fuel products. EU is clearly lagging the rest of the world in the adoption of methane as the next gen fuel for locomotive applications. Being European company DiGas is bringing to market dual fuel product dedicated for locomotive sector out competing all similar products on a global scale. With today’s average cost of locomotive dual fuel retrofit 500k EUR, the proprietary game changing innovation enables multiple times decrease of locomotive retrofit costs combined with high diesel fuel substitution rate (60-80%) of the system allowing for commercially attractive payback periods (4 y for shunter and 2 y for main-lines) for rail operators. In project Phase 1 DiGas strives to investigate project risks and potential hurdles of the product commercialization kick-off in Phase 2, for example certification and homologation routes, rail rolling stock and customer for various countries as well as commercialization path for various markets delivering a solid business plan. Based on feasibility study, a strategy TRL raise from 6 to 9 and market-rollout will be defined.

Keywords: rail,locomotive,locomotive engines,dual fuel,gaseous fuel,liquefied natural gas lng,compressed naturnal gas cng,natural gas
A new wearable, cost effective and non-invasive biometric solution for accurate and high throughput screening of people, bags and vehicles (Bio-AX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: United Kingdom
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

AUDAX Global Solutions Ltd. is an SME founded in Plymouth UK in 2005. Since then it has become a pioneer in the delivery and development of mobile digital evidence gathering products and services. The AUDAX team consists of the most knowledgeable experts in the industry who are committed to offer ground breaking innovative solutions. AUDAX owns a new technology Bio-AX™, a new wearable, cost-effective and non-invasive biometric solution for accurate and high throughput screening of people, bags and vehicles. This technology will bring many benefits to the stakeholders and increase security in our communities. AUDAX sees a huge business opportunity through sales. The uniqueness of Bio-AX™ will increase the Unique Selling Proposition (USP) of our products and competitive advantage in the market. AUDAX believes that Bio-AX™ will raise the Company’s profitability and grow its workforce. AUDAX has invested in Bio-AX™ and it is now in prototype phase. However, the Company requires further financing through SME Instrument to fund the transition of the prototype into commercialisation. In Phase 1 our specific objective is to prepare a clear Feasibility Study and Business Plan to determine the feasibility, possibility, viability and sustainability of this new project.

Keywords: wearable biometric system
Autocatalytic Self-Synthesising Polymersomes (AutoPolymer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Polymersomes, hollow polymer vesicles made from assembled amphiphilic block copolymers, are interesting systems for drug delivery as they can be synthesised to be biocompatible, biodegradable, and/or stimuli-responsive. A main limitation of all drug delivery vehicles is that they require multiple steps of synthesis and a posterior self-assembly process that generates low yields and high quantities of non-encapsulated waste, limiting industrial scalability. Being hosted in the Stevens Group (www.stevensgroup.org, recognised with over 30 major awards), AutoPolymer aims at generating a versatile platform for the generation of polymersome-based drug delivery vehicles which can self-replicate by synthesising amphiphilic block copolymers in the lumen, with the future perspective of co synthesising encapsulated therapeutic agents. The strategy builds on finding bioinspiration in nature, mimicking the autosynthesis of structural components of cells through the mitosis process. This will be achieved by generating enzyme-containing polymersomes which have the capacity to biocatalyse polymerisation reactions. The polymers will be synthesised in the lumen of the polymersomes and will then migrate and assemble to the existing membrane. This will allow for membrane surface area growth and posterior binary fission splitting the encapsulated contents. The incorporation of light responsive chemical motifs to the polymersomes throughout their autosynthesis will be studied to render light-responsive drug delivery vehicles. The polymersomes will be tested for their therapeutic effects on cell lines. The approach is highly versatile and could, in principle, be used for a great variety of chemical compositions and encapsulated therapeutic agents. The potential of the project will be evaluated through the outstanding infrastructure of the Stevens Group.
Asymptotic invariants of discrete groups, sparse graphs and locally symmetric spaces (InvGroGra)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Hungary
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1386250.0
EU funding (EUR): 1386250.0
Participants: 1
Project status: CLOSED

The PI proposes to study the asymptotic behavior of various invariants of discrete groups and their actions, of sparse graphs and of locally symmetric spaces. The game is to connect the asymptotic behavior of an invariant on a sequence of finite models to an analytic invariant on a suitable limit object of the sequence and then use the connection to get new results in both the finite and infinite worlds. The recently emerging notion of invariant random subgroups, initiated by the PI, serves as a unifying language for convergence. These invariants include the minimal number of generators, deficiency, Betti numbers over arbitrary fields, various spectral and representation theoretic invariants, graph polynomials and entropy. The limit objects arising are invariant processes on groups, profinite actions, graphings, invariant random subgroups and measured complexes. The analytic invariants include L2 Betti numbers, spectral and Plancherel measures, cost and its higher order versions, matching and chromatic measures and entropy per site. Energy typically flows both ways between the finite and infinite world and also between the different invariants. We list five recent applications from the PI that emerged from such connections. 1) Any large volume locally symmetric semisimple space has large injectivity radius at most of its points; 2) The rank gradient of a chain equals the cost-1 of the profinite action of the chain; 3) Countable-to-one cellular automata over a sofic group preserve the Lebesque measure; 4) Ramanujan graphs have essentially large girth; 5) The matching measure is continuous for graph convergence, giving new estimates on monomer-dimer free energies. Besides asymptotic group theory and graph theory, the tools of the proposed research come from probability theory, ergodic theory and statistical mechanics. The proposed research will lead to further applications in 3-manifold theory, geometry and ergodic theory.

Keywords: measured group theory,rank gradient,invariant random subgroups,homology growth,graph polynomials,local limit theorems,sofic entropy,graph convergence,cellular automata,locally symmetric space
European programme for the establishment of validated procedures for the detection and identification of biological toxins (EuroBioTox)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Innovation actions
Countries involved: Germany,Germany,Switzerland,Finland,Switzerland,Belgium,Sweden,France,France,United Kingdom
Call: Validation of biological toxins measurements after an incident: Development of tools and procedures for quality control (H2020-SEC-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 9526721.25
EU funding (EUR): 7998747.0
Participants: 14
Project status: SIGNED

Recent incidents in Europe and worldwide have threatened civil society by the attempted use of different biological toxins and have thereby shown that increased vigilance and adequate preparation is of increasing importance in a world facing growing risks of man-made disasters. Previous studies which the consortium is well acquainted with showed that there is a lack of robustness in European preparedness for biotoxin incidents. There is a need for standard analytical tools and procedures, reference materials, state-of-the-art training and establishment of a European proficiency testing scheme. Using current best practice, the EuroBioTox core members will develop and validate improved analytical tools, reagents and standard operating procedures based on realistic incident scenarios. Certified Reference Materials for the threat biotoxins will be developed and, by establishing a European repository, will be made available to the EuroBioTox network including more than 50 European organisations, expert laboratories, industrial partners and end-users. Training courses at basic and advanced levels will be developed and attended by the EuroBioTox network partners, followed by a series of proficiency tests which, through these “outer circle” associates, will disseminate best practice methods across Europe. The current animal test for botulinum neurotoxin is ethically unacceptable and alternative in vitro tests will be evaluated. After this project there will be a pan-European network of competence, certified reference materials, standard operating procedures and a common way of handling biotoxin incidents.

Keywords: biological toxins,standardisation,proficiency testing,certified reference materials,animal replacement methods
Global existence and Computer-Assisted Proofs of singularities in incompressible fluids, with Applications (CAPA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1483073.0
EU funding (EUR): 1483073.0
Participants: 1
Project status: CLOSED

The goal of this proposal is twofold: on the one hand to pursue methods and ideas developed in recent work in the search for either singularities or global existence in incompressible fluids with finite energy and on the other transfer the techniques to solve long-standing open problems in spectral geometry. A key ingredient in its success is to have accurate numerics together with a deep understanding of the regularity theory. Therefore, the interdisciplinary nature of this project, which involves numerical computations, computer-assisted proofs, modern PDE methods and harmonic analysis, is an essential ingredient for the successful outcome. This proposal is divided in three blocks, the first two involving global existence and/or singularities for: the incompressible Euler and Navier-Stokes equations; the surface quasi-geostrophic (SQG), the generalized-SQG equations and related models; and a third one on applications to spectral geometry. There is a strong analogy between the SQG and the 3D Euler equations, and many results that hold for the former also hold for the latter. A major theme is the interplay between rigorous computer calculations and traditional mathematics. Interval arithmetics are used as part of a proof whenever they are needed. As an evidence of its capabilities, I have pioneered techniques to show singularities in PDE related to fluid mechanics – even in low regularity settings –, developed a way to treat singular integrals, and solved eigenvalue problems using computer-assisted proofs. This is a completely novel approach that can be blended with more classical ones, resulting in very powerful theorems solving problems that can not be treated currently with pen and paper methods.

Keywords: computer assisted proof,surface quasi geostrophic,spectral geometry,free boundary,incompressible,euler,navier stokes,patches
Training the next generation of scientists in solar chemicals for a sustainable Europe by hybrid molecule/semiconductor devices (SOLAR2CHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany,Spain,Ireland,Belgium,Switzerland,Finland,Hungary,Denmark,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-02-01
End date: 2024-06-30
Duration (months): 53.0
Total project cost (EUR): 4037074.04
EU funding (EUR): 4037074.04
Participants: 12
Project status: SIGNED

SOLAR2CHEM will train 15 early stage researchers to fill the existing gap in the European industrial landscape in the area of solar chemicals production and usage in technical, economic and policy aspects. The consortium is formed by 12 beneficiaries including 9 academic and 3 non-academic organisations plus 8 partner organisations to cover a full training programme on scientific, technical and personal development skills which will include secondments in current world leading countries (Japan, US, Australia) to gather the necessary knowledge and implement it in Europe. The main objectives of the programme are i) to train 15 ESRs in state of the art concepts and techniques, with a strong focus on interdisciplinary knowledge on physical sciences (chemistry, physics, materials science and engineering), providing communication, leadership, management skills and solid professional connections; ii) to advance knowledge on hybrid devices for solar chemicals production focussing on novel molecules and materials exceeding current efficiencies and selectivity, while considering the environmental footprint based on materials availability and manufacturing process. Special attention will be given to state of the art characterisation techniques and modelling; and iii) to cover the promotion of solar chemicals within policy-makers and stakeholders, and the development of the private sector through communication to the general public. Strong links with industrial partners and technology transfer offices will ensure that the existing gap is filled.

Keywords: carbon based semiconductors,graphene,solar chemicals,reactor design and modeling,photoelectrocatalysis,photochemistry,electrocatalysis
C9orf72-mediated neurodegeneration: mechanisms and therapeutics (C9ND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 1985699.0
EU funding (EUR): 1985699.0
Participants: 1
Project status: CLOSED

An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat RNA is transcribed and accumulates in neuronal RNA aggregates, implicating RNA toxicity as a key pathogenic mechanism. However, the pathways that lead to neurodegeneration are unknown. My lab has made pioneering contributions to the understanding of C9orf72 FTD/ALS, and reported the first structure of the repeat RNA, and the first description of both sense and antisense RNA aggregates in patient brain. We have now developed new disease models that allow, for the first time, the dissection of RNA toxicity both in vivo and in sophisticated neuronal culture models. We have also used our knowledge of the repeat structure to identify novel small molecules that show very strong binding to the repeats. We will utilise our innovative disease models in a multidisciplinary approach to fully dissect the cellular pathways underlying C9orf72 repeat RNA toxicity in vivo, on a genome-wide scale. Altered RNA metabolism has been implicated in a wide range of neurodegenerative diseases, indicating that our findings will provide profound new insight into fundamental mechanisms of neuronal maintenance and survival. This research programme will also deliver a step change in our understanding of C9orf72 FTD/ALS pathogenesis and provide essential insight for the identification of small molecules with genuine therapeutic potential. RNA-mediated mechanisms are now known to be a common theme in neurodegeneration, suggesting these findings will have broad significance.
High-density cortical implants for cognitive neuroscience and rehabilitation of speech using brain-computer interfaces. (BrainCom)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Switzerland,France,France,France,United Kingdom,United Kingdom,Luxembourg
Call: FET Proactive: emerging themes and communities (FETPROACT-2016, 2016)
Start date: 2016-12-01
End date: 2022-04-30
Duration (months): 65.0
Total project cost (EUR): 8648827.89
EU funding (EUR): 8359862.5
Participants: 17
Project status: CLOSED

The goal of BrainCom is to develop a new generation of neuroprosthetic devices for large-scale and high density recording and stimulation of the human cortex, suitable to explore and repair high-level cognitive functions. Since one of the most invalidating neurospychological conditions is arguably the impossibility to communicate with others, BrainCom primarily focuses on the restoration of speech and communication in aphasic patients suffering from upper spinal cord, brainstem or brain damage. To target broadly distributed neural systems as the language network, BrainCom proposes to use novel electronic technologies based on nanomaterials to design ultra-flexible cortical and intracortical implants adapted to large-scale high-density recording and stimulation. The main challenge of the project is to achieve flexible contact of broad cortical areas for stimulation and neural activity decoding with unprecedented spatial and temporal resolution. Critically, the development of such novel neuroprosthetic devices will permit significant advances to the basic understanding of the dynamics and neural information processing in cortical speech networks and the development of speech rehabilitation solutions using innovative brain-computer interfaces. Beyond this application, BrainCom innovations will enable the study and repair of other high-level cognitive functions such as learning and memory as well as other clinical applications such as epilepsy monitoring using closed-loop paradigms. BrainCom will be carried out by a consortium assembled to foster the emergence of a new community in Europe acting towards the development of neural speech prostheses. Thanks to its high interdisciplinarity involving technology, engineering, biology, clinical sciences, and ethics, BrainCom will contribute advances to all levels of the value chain: from technology and engineering to basic and language neuroscience, and from preclinical research in animals to clinical studies in humans.

Keywords: speech neuroprostheses,neurorehabilitation,brain computer interfaces,nanomaterials,flexible neuroelectronics,high density cortical implants,cortical dynamics,neuroethics