Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vertical GaN on Silicon: Wide Band Gap Power at Silicon Cost (YESvGaN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Spain,Italy,Italy,Austria,Germany,Germany,Germany,Germany,Austria,Germany,Italy,Germany,Germany,Italy,Italy,Germany,Belgium,Sweden,Belgium,France,France,France,France
Call: ECSEL-2020-2-RIA (H2020-ECSEL-2020-2-RIA-two-stage, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 26998506.26
EU funding (EUR): 7797661.5
Participants: 28
Project status: SIGNED

YESvGaN targets a new low-cost wide band gap (WBG) power transistor technology for enabling high-efficiency power electronic systems in the field of electromobility, industrial drives, renewable energies and data centers. In many applications requiring power transistors with high voltage and current rating (600…1200V, ~100A), silicon IGBT technology is nowadays used due to cost considerations accepting its lower efficiency compared to WBG solutions. The main objective of YESvGaN is to demonstrate innovative vertical gallium nitride (GaN) power transistors fabricated on a low-cost substrate such as silicon. This so-called vertical membrane architecture combines the superior performance of GaN as WBG power transistor material with the advantages of a vertical architecture regarding current and voltage robustness at a price competitive to silicon IGBTs. To this end, the entire value chain from substrate, epitaxy, process technology, interconnection technology to application in relevant power electronic systems is addressed. YESvGaN clusters the relevant competences along the value chain in a consortium of large companies, SMEs and institutes from seven European countries.

Keywords: wide band gap power transistors,future generations,vertical gallium nitride,power semiconductors
Nanoparticle Biointerface Mapping (NanoBioMap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The Nanoparticle Biointerface Mapping project builds on the extensive bionano interactions research in the group of Professor Kenneth Dawson at University College Dublin. In the NanoBioMap project I propose a cutting-edge interdisciplinary approach to develop a versatile tool allowing me to obtain detailed 3D maps of biomolecules at the surface of nanoparticles in complex biological media and study their importance for cell interactions. I will build on my extensive knowledge of nanomaterial science to develop this 3D mapping tool combining a tailor-made library of antibody-tagged quantum dots with electron microscopy 3D image reconstruction and X-ray elemental mapping. The resulting versatile method has multiple uses far beyond analyzing protein coronas. I envision applications of this state-of-the-art mapping tool in areas such as vaccine development, enzymatic catalysis on supported particles, cancer treatment and tracking of pollutants in water flows. The proposed project has 4 objective which will be reached over 24 months, within 13 work packages, including training-through-research and acquisition of transferable and complementary skills, contributing to the advancement of my career beyond this project, as a future independent researcher. The main objective is developing a tool to allow 3D mapping of protein epitopes at the surface of nanosized objects, with applications far beyond my test systems. The other objectives involve testing my tool to map epitopes in the protein corona at nanoparticles and study their interaction with cell receptors, focusing on spatial distribution of specific receptors. The proposal builds on my current extensive knowledge of nanomaterial synthesis, surface modification and characterization in complex environments adding a cell biology dimension, thus expanding my knowledge and career prospects.

Keywords: protein epitope mapping,interdisciplinary,quantum dots,antibodies,protein corona,catalysis,nanomedicine,biomolecules
Synchrotron Miniaturization enabling Innovative Laboratory Equipment in soft x-ray tomography. (SMILE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Ireland
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-01-01
End date: 2019-02-28
Duration (months): 26.0
Total project cost (EUR): 3000935.0
EU funding (EUR): 3000935.0
Participants: 1
Project status: CLOSED

The aim of SMILE is to support SiriusXT in moving a prototype of its soft x-ray microscope (SXT100) from prototype to commercial product through addressing ease-of-assembly, manufacturing scale-up, serviceability, customer pilots, regulatory pathways and business model requirements. The disruptive innovation delivered by SMILE is to open up the market for soft x-ray imaging from approx. 100 users today to an immediate target addressable market of over 3,000 disease research and drug discovery organisations by reducing the cost of the microscope assembly by a factor of over 200 (from over €500 million to €2.5 million) and miniaturizing its size, by a factor of 5,000 (from 15,000m2 area to approx. 3m2). Soft x-ray imaging is the only means available today of generating high resolution, high contrast, 3D images of the internal structure of whole biological cells in their near-natural state. Cell researchers currently spend approx. €500m annually on electron and optical microscopes in order to increase their understanding of subcellular structure and how this relates to disease progression and therapy, however neither of these technologies is capable of imaging the whole internal cell structure. The SXT100 gives disease research and drug discovery organisations daily access to a soft x-ray microscope in their own labs, rather than having to queue for often more than six months to get a few hours of access to one of only four synchrotron locations around the world where a suitable soft x-ray source and microscope exists today. The SXT100 will not only increase a researcher’s productivity 100-fold, in the number of biological cells they can image, but it also allows them to carry out a range of disease progression studies, not possible today because of the restricted access to these synchrotron microscopes. SMILE is predicted to have a significant impact in addressing the EU/global challenge in reducing the cost of healthcare delivery and developing cures for disease.

Keywords: healthcare,drug discovery,soft x ray imaging,tomography,synchrotron,whole cell imaging,cell biology
Vertical Transport and Photoresponse in van der Waals hybrid structures (TranspvdW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Van der Waals (vdW) hybrid structures, new systems formed by stacking layers of two-dimensional crystals on top of each other, are a promising route towards the tailoring of material properties at will. Understanding the properties of individual layers and how they interact with each other to obtain the desired properties is the main focus of both experimental and theoretical research of the community working in this area. Due to the extreme high quality, atomically sharp, interfaces between different layers in vdW structures, lattice mismatch and the relative alignment between consecutive layers play a fundamental role in determining the properties of the vdW structure, governing the electronic coupling between different layers. Graphene – insulator/semiconductor – graphene vdW structures have recently received a lot of attention from the community, due to its potential for applications, having been shown to operate both as transistors and photodetectors. It is not clear however how device operation is affected by lattice mismatch effects. The aim of this project is to develop theory and models, both analytical and numerical, to describe the vertical current and photocurrent generation, both in the steady state and in the transient regime, of the vdW hybrid structures referred above. Special attention will be given to the effect of lattice mismatch and crystal-momentum conservation in the vertical current flow. In the duration of this project, Bruno Amorim will work under the supervision of Prof. Eduardo V. Castro in the multidisciplinary environment provided by the Center of Physics and Engineering of Advanced Materials at Instituto Superior Técnico, in Portugal. This project will generate high impact results, useful in interpreting current and future experimental results and in guiding the design of new vdW devices. As such, this project will greatly contribute to the career development of the applicant.

Keywords: 2d materials,van der waals structures
Peer2Scale-Health: Peer-learning action to improve innovation support to health SMEs in their scale-up process (Peer2Scale-Health)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Germany,Belgium,France
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2018)
Start date: 2019-06-01
End date: 2020-05-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 4
Project status: CLOSED

Peer2Scale-Health is a 12-month peer-learning action proposed by 4 regional health innovation agencies acting as clusters providing specific innovation support services to their network of health SMEs: Eurasanté (Hauts-de-France), BioM (Bavaria), Biocat (Catalonia) and lifetech.brussels (Brussels). This Twinning+ project is about a mutual learning on our best practices and the design of a common innovation programme around the concept of raising “entrepreneurship skills” in health entrepreneurs and SMEs, at the time they go through the critical scale-up process. The project addresses a triple-demand coming from: SMEs facing specificities of health sector (time-to-market, financial needs, regulation…), innovation agencies but also the EU (competitiveness of the life sciences sector). The final DOP will help to engage more health innovation agencies in a peer-learning action, and will nurture a follow-up initiative to further implement the co-designed programme, for the benefit of SMEs.

Keywords: scale up,health,smes,start ups,peer learning,health innovation agencies,health clusters
A synergistic approach toward understanding receptor signaling in the cell at very high resolution (HighResCells)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Switzerland,Denmark
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-03-01
End date: 2024-11-30
Duration (months): 69.0
Total project cost (EUR): 8273457.0
EU funding (EUR): 8273457.0
Participants: 3
Project status: SIGNED

Members of the Epidermal Growth Factors Receptor family (EGFRs) influence cell growth and proliferation, and are pivotal in all phases of tumor progression. We will use this receptor family as an example with which to develop a ground-breaking new technology to study cellular signaling towards atomic resolution, in situ. Therefore, we propose to employ an interdisciplinary approach for studying EGFR family of receptors, where we follow their conformational and oligomeric states as well as bound ligands and signal transduction molecules during different activation states at atomic resolution in situ. We will progress from engineered to native receptor forms, and from defined membrane vesicles to whole cells, and employ 3D structure analysis by cryo-electron tomography, greatly enhanced by novel image processing approaches, mass spectroscopy definitions of receptor modifications and interaction partners, as well as advanced protein engineering to identify, orient and freeze receptors for this method development. This collaborative project addresses the properties of the EGFR family across a wide range of complexity and dimensions, in the cellular environment, through their high-resolution structures and changes during receptor recycling. This collaborative network, addressing EGFR from complementary angles, is most likely to generate substantial new information on these assemblies and to yield a deep understanding of the mechanisms underlying their structure and function. The EGFR family has been the focus of many tumor therapies, with the aim of intercepting their signaling, and this project will contribute to a more detailed understanding of their mode of action and thus the more rational development of such therapies in the future. However, the technology that will be developed will be generally applicable and may thus help to contribute to a paradigm change for structural biology, enabling atomic resolution description of receptors in their cellular environment.

Keywords: cryo electron tomography,protein engineering,protein design,organelle proteomics,egfr family
Development of a hybrid methodology for the susceptibility and hazard analysis of landslides (HYBLAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-18
End date: 2024-04-17
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 2
Project status: SIGNED

The activation as well as the consequences of natural geohazards, such as landslides, are difficult to predict, as they depend on factors characterized by large uncertainties, such as the geological and geotechnical conditions, and the influence of human activities. The proposed study aims at the development of a novel, reliable and comprehensive method for the estimation of the landslide susceptibility and hazard. The individual goals of this study are: a) to investigate the failure mechanism of landslides and their spatio-temporal spread using an approach which combines the Earth Observation technology with the classical geotechnical research, b) to formulate an effective multimodal determinist approach for landslide susceptibility assessment, c) to develop a landslide susceptibility and hazard assessment method based on Machine Learning, d) to combine the two previous methods, effectively creating a novel, highly performing methodological approach. The new method will be able to manage more effectively the uncertainties, giving reliable results even in areas where there is scarcity of landslide records. The testbed area for the development of the new approach will be southwestern Cyprus, a region with very high density of landslide phenomena due its particular geology and relatively high seismicity. The produced hazard maps will allow the identification of areas which are susceptible to landslides and, consequently, the results of this research will help the decision-makers in taking actions towards protecting the built environment from the landslide hazards, thus securing sustainable development. Eventually, after the validation of the new method and produced maps, this process can be applied in other parts of Europe suffering from similar phenomena.

Keywords: natural hazards,landslides,risk assessment,earth observation,machine learning,susceptibility and,hazard map
Ebola Virus: Modern Approaches for developing bedside Rapid Diagnostics – Sofia ref.: 115843 (EbolaMoDRAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,Germany,Italy,Finland,Finland,Sweden,Belgium,France,France,Denmark,United Kingdom,United Kingdom,Senegal
Call: Rapid diagnostic tests (H2020-JTI-IMI2-2014-02-single-stage, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 4300935.0
EU funding (EUR): 4300935.0
Participants: 18
Project status: CLOSED

The current Ebola Virus Disease (EVD) outbreak has caused more than 5000 deaths within a few months in West Africa (Guinea, Sierra Leone and Liberia being the most severely affected countries), including numerous healthcare workers. It is now is serious public health crisis of international concern . The numbers of cases are still increasing 11 months after the first case was described (December 2013), by mid November 2014 approximately 15000 individuals have been infected and the epidemic is still not under control The direct effects of this outbreak include disruption of standard medical care, insecurity and social disruption in countries that were already struggling to recover from decades of war. One of the most important key actions to limit and stop the spread of this deadly disease is to identify and isolate the EBOV-infected patients. The diagnosis of Ebola Virus infections has in the past, been performed overwhelmingly in specialist reference laboratories with high-performance molecular, serological and culture methods.In recent years many of these functions have been mobilised into rapid response mobile laboratories, indeed several of these units supported by, European, CDC/USA, Canadian, Chinese and African states have been set up to help in the current outbreak by performing laboratory diagnosis, in collaboration with national centres in West Africa. While this type of response has been effective in helping control past EVD outbreaks in rural parts of Africa, it has not been as effective at controlling the current outbreak which is now spreading in densely populated city and slum areas. Unfortunately, the diagnostic procedures currently used in the mobile laboratories are associated with several problems: i) there are a limited number of diagnostic hubs, ii) performing the diagnostic tests correctly requires specialist training, skill and experience, consequently there a limited numbers of trained staff

Keywords: ebola virus,rapid diagnostic,biosafety,molecular diagnostic,serological diagnostic
Qualification of innovative floating substructures for 10MW wind turbines and water depths greater than 50m. (LIFES 50plus)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Spain,Spain,Norway,Norway,France,Denmark,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2014-1, 2014)
Start date: 2015-06-01
End date: 2019-04-30
Duration (months): 47.0
Total project cost (EUR): 7274837.5
EU funding (EUR): 7274837.5
Participants: 17
Project status: CLOSED

The focus of the project will be on floating wind turbines installed at water depths from 50m to about 200m. The consortium partners have chosen to focus on large wind turbines (in the region of 10MW), which are seen as the most effective way of reducing the Levelized Cost of Energy (LCOE). The objective of the proposed project is two-fold: 1. Optimize and qualify, to a TRL5 level, two (2) substructure concepts for 10MW turbines. The chosen concepts will be taken from an existing list of four (4) TRL>4 candidates currently supporting turbines in the region of 5MW. The selection of the two concepts will be made based on technical, economical, and industrial criteria. An existing reference 10MW wind turbine design will be used throughout the project. 2. More generally, develop a streamlined and KPI-based methodology for the design and qualification process, focusing on technical, economical, and industrial aspects. This methodology will be supported by existing numerical tools, and targeted development and experimental work. It is expected that resulting guidelines/recommended practices will facilitate innovation and competition in the industry, reduce risks, and indirectly this time, contribute to a lower LCOE. End users for the project deliverables will be developers, designers and manufacturers, but also decision makers who need to evaluate a concept based on given constraints. The proposed project is expected to have a broad impact since it is not led by single group of existing business partners, focusing on one concept only. On the contrary, it will involve a strong consortium reflecting the value chain for offshore wind turbines: researchers, designers, classification societies, manufacturers, utilities. This will ensure that the project's outcomes suit the concrete requirements imposed by end-users.

Keywords: wind energy,offshore,floating structures,reduced lcoe,innovation,emulation,guidelines