Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INNOVATIVE APPROACHES TO PHENOTYPE MOOD DISORDERS IN MOUSE MODELS (MODELMOOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2014-01-31
Duration (months): 12.0
Total project cost (EUR): 128182.1
EU funding (EUR): 128182.1
Participants: 1
Project status: CLOSED

Major depression is a potentially life-threatening illness affecting 10-15% of the population and causing an enormous economic burden (Euros 120 billions/year in Europe), also due to incomplete efficacy of antidepressants. The most relevant cause of this is the poor knowledge of the neural basis for mood regulation that has to be attributed, among other factors, to the limited information gathered from animal models. The main aim of the present project is setting up an innovative strategy for comprehensive, detailed phenotyping of mouse models of depression. Experimental protocols for investigating behavioural responses involved in the depression phenotype, such as “pessimistic” bias and an altered social behaviour, will be developed in an automated apparatus. These protocols will be used in combination with already validated protocols (e.g. anhedonia, sleep/wake cycle) to obtain a comprehensive, automated and high-throughput phenotyping strategy to assess depression-like behaviour in mice and to screen antidepressant action. Translation research resulting into clinical application for brain research is a central priority in Europe in the context of psychiatric disorders. The high throughput screening combined with strong hypothesis on the evolutionary basis of the behaviours to be modelled can have important consequences on the health, societal and economic burden imposed by major depression, leading to improved drug development. Being able to work in an environment where industry and academia collaborate strongly, such as the host environment, will allow the candidate to better exploit new knowledge for its technological transfer into SME products and will lead to a close cooperation with leading scientists and engineers. Ultimately the opportunity given by this fellowship will endow him with the necessary skills to develop his own research team and to advance the field on innovative animal models for the study of mood disorders.

Keywords: neurosciences,behavioural sciences
Measuring Magnetic Monopoles Using Quantum Metrology in Diamond (QUANTUM METROLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-09-01
End date: 2015-08-31
Duration (months): 36.0
Total project cost (EUR): 271943.7
EU funding (EUR): 271943.7
Participants: 1
Project status: CLOSED

This proposal seeks to develop state of the art quantum metrology in diamond to probe a magnetic monopoles in spin ice. It will accomplish this by establishing an interdisciplinary collaboration between two world-leading groups, the Yacoby group at Harvard and the Bramwell group at the London Centre for Nanotechnology at University College London. Since the Harvard group purchases the diamond samples commercially, and this fellowship will allow the transfer of their expertise, it offers a particularly sustainable route to the permanent integration of the knowledge in the EU. The results of this fellowship promise to be extremely intersting from both a fundamental and technological perspective, and it is expected to lead to several high profile publications.

Keywords: physical sciences,magnetic monopoles,quantum metrology,nanotechnology,magnetometry
Scanning tunneling spectroscopy of topological interfaces for future spintronics (TOPOSPIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 263660.7
EU funding (EUR): 263660.7
Participants: 1
Project status: CLOSED

In the last thirty years great progress in solid state physics was mainly driven by the discovery of novel highly unique material systems. Materials such as high tc superconductors, carbon nanotubes, semiconductor nanowires and graphene reshaped our understanding of modern solid state physics. In particular, each of these materials opened a new chapter in the multidisciplinary fields of nanotechnology and nanoscience. In this context, recently discovered topological insulators, a remarkable new material system, has at least the same potential. The unique properties of these materials such as topological protection of the surface states, transport channels and spin textures that arise due to non-trivial band structure promise to open new areas of quantum computing and spintronics. Moreover, these materials may even solve some long standing puzzles arising from fundamental quantum mechanics and elementary particle physics. This fellowship will enable transfer of knowledge of topological insulators from the world leading group in the field at the Princeton University, to the arguably best groups in Europe.

Keywords: physical sciences topology,quantum computation,nanoscience,topological insulators,quantum states of matter
Precision Physics and Discovery at Hadron Colliders with Heavy Quarks (TOPPHYSICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 257874.8
EU funding (EUR): 257874.8
Participants: 1
Project status: CLOSED

In the next years, due to the exceptional performances of the Tevatron and to the really promising start of activity of the Large Hadron Collider (LHC) at CERN, it will be possible to study Physics with high precision at an energy scale never reached so far. The study of the Electroweak Symmetry Breaking (EWSB) and the origin of mass, of the validity range of the Standard Model (SM) and the possible discovery of new phenomena beyond it, will push Particle Physics towards a deeper understanding of the laws that govern the Universe. Top-quark physics will play a crucial role, representing a unique probe of the dynamics that breaks the EW symmetry and then an active discovery channel for new physics. The research project here proposed will provide a complete and accurate theoretical description of the observables involved in the production and decay of top quarks at the LHC , both in the SM and in models of new physics. We propose a detailed study of the QCD NNLO corrections to the top-antitop production in hadronic collisions, considering the decay products of the top, with the implementation of such a corrections in a public Monte Carlo event generator for a reliable phenomenological study. Moreover, a complete, model-independent, analysis at the NLO of the top-antitop pair and single-top productions in presence of new resonant states will be carried out. Also in this case, the results will be implemented in a Monte Carlo event generator. The goals of such a project are: 1) to set up the state of the art for the SM predictions as reference for phenomenological analysis of New Physics, 2) to find hints for the study of the properties of the New Physics, 3) to find new techniques and new strategies for multi-loop calculations in a new precision era of Particle Physics.

Keywords: quantum field theory,particle physics phenomenology,physics at high-energy colliders,perturbative qcd,multiloop calculations
AIP gene regulation and its implications in pituitary tumorigenesis (REGAIP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Background: Pituitary adenomas are a public health problem, due to their prevalence, morbidity and medical costs. AIP is a tumor suppressor gene that was recently linked to pituitary tumors in up to 30% of the familial isolated pituitary adenoma syndrome (FIPA) families, an autosomal dominant disease with incomplete penetrance. AIP mutation-positive patients are younger (children/young adults), have more aggressive disease, and respond less well to treatment than non-mutated patients. The mechanisms by which inactivating AIP mutations promote tumorigenesis remain unknown. Abnormal, mislocalised AIP expression in sporadic pituitary adenomas suggest a possible role in sporadic pituitary adenoma development as well. Very little is known about the normal and pathological regulation of AIP expression. Objective: To uncover major AIP transcription regulation by its canonical promoter, miRNA species and epistatic action of distant regulatory SNPs (eQTLs). Methods: 1) In vitro functional promoter dissection and identification of operating transcription factors and investigation of promoter mutations in FIPA families. 2) Screening and validation of miRNA species acting on AIP and study of their expression in pituitary adenomas and correlation with clinical / pathological features. 3) Detection and validation of AIP eQTLs and study of their implication in AIP mutation penetrance and their association with sporadic pituitary adenomas and their clinical/pathological features. Work programme relevance: Training through research in a major European pituitary centre will ensure development of essential experimental, theoretical and organizational skills of the fellow and will advance research at the host institution, thus improving quality of research at the ERA. The research results will have a significant impact not only on pituitary research, but also endocrinology (including pediatrics) and cancer research.

Keywords: genetic mapping,molecular genetics,gene function regulation,promoter analysis
Large-scale protein expression profiling of genes implicated in cognitive disorders and dissection of their role in neural tissue development and plasticity (NEUROPROTEIN PROFILE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2015-07-13
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

Cognitive disorders are, due to their high frequency and lifelong costs, a leading medical and socio-economical problem world-wide. Particularly for the large number of disorders characterized by intellectual disability, no therapy is available. The search for effective treatment is unlikely to be successful until the pathology of these disorders is better understood. Currently mutations in around 300 human genes are known to cause cognitive disorders. These genes provide an exciting molecular window into fundamental neuroscience and translational research. In 2010, a large international project, FP7 GENCODYS, has been started to characterize their function on the large scale. An early outcome of this project is a systematic library of Drosophila strains that express the fly homologs of human cognitive disorder disease genes as fluorescently tagged (and thus easily traceable) proteins, under their endogenous genomic regulatory control. Combining this novel native reporter toolbox with modern microscopy techniques I propose to create and assemble high-resolution 3D maps of gene expression profiles of these genes in the nervous tissue during embryonic development and in the adult brains of fruitflies, the two conditions most relevant to their associated human disease pathologies. Adult gene expression patterns will be generated under both the steady-state and the stimulated brain activity conditions in order to uncover key factors of neuronal plasticity. We expect these unique charts of plastic neuronal activity to significantly contribute to our understanding of higher brain function in health and disease. They will also facilitate the identification of common molecular pathways that can be targeted for effective treatment of cognitive disorders.

Keywords: natural sciences,health sciences,drosophila,neurobiology,fluorescence,imaging,protein expresion,neuroplasticity
Eurosceptic Populist Party Organization and Representation: A Comparative Study (POPREP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 193726.8
EU funding (EUR): 193726.8
Participants: 1
Project status: CLOSED

This proposal can be summed up under the following two headings 'Project' and 'Training'. While separate here for clarity, the conduct and success of each is essentially intertwined with - and dependent on - the other: (1) PROJECT: The project analyzes party organization and representation in six Eurosceptic populist parties: the Northern League (Italy), Sinn Féin (Ireland), the Swiss People's Party (Switzerland), Front National (France), the Danish People's Party (Denmark) and the Socialist Party (Netherlands). No comparative indepth study of this type, depth and breadth currently exists. The approach taken is conceptually innovative, methodologically interdisciplinary and theoretically ambitious. It answers calls for empirical research on populism by scholars and by the European Union itself (Work Programme, 2010). The research aims to provide the first comparative empirical study to date of Eurosceptic populist organization and representation, in a monograph with a top international publishing house, thus helping me achieve a leading independent academic position and an international profile as a key comparative European politics scholar. (2) TRAINING: Given the ambitions both of this project and my own career goals, high quality training in applied interdisciplinary methods, data analysis and project management are all essential prerequisites. With advice and support from renowned scholars and colleagues at the EUI, the overall aim of this fellowship is to build on my prior research career, but take it now to a far greater level of comparative and theoretical breadth, sophistication and originality thanks to the quality of mentorship, training and international research environment offered by the EUI. Through the skills acquired - and applied in the project - I will mature enormously as a scholar.

Keywords: political science,political parties,comparative politics,representation,party organization,populism,euroscepticism,ethnography
Mapping Spatial Interaction Networks in Honeybee Colonies (BEESPATNET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-01-01
End date: 2014-12-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

When individuals that live in extended family groups- such as honeybees- the entire society is vulnerable to infection of just a single colony-member, as the same networks that are optimised for efficient transmission of information or food, may be hijacked by the pathogen. Nevertheless, mechanisms have evolved to reduce the spread of disease across social or communication networks. For example, infected ants commit altruistic suicide by removing themselves from the colony entirely. Similarly, the organisational structure of the contact network itself can mitigate disease spread through compartmentalisation. These strategies serve to reduce transmission by lowering the probability of direct contact between infected and uninfected individuals or groups. Indeed, to date, all studies on disease transmission within animal societies have focused entirely on networks in which the links represent direct physical contact. Worldwide, honeybee populations are suffering a rapid decline (Colony Collapse Disorder), and the causative factor(s) are unknown. Several honeybee parasites implicated in CCD, do not require direct contact between individuals to jump host. This project will focus on the potential for indirect disease transmission in the honeybee. An infected individual that moves through the nest could potentially deposit a pathogen anywhere along its path. So even if two individuals never physically encounter each other, if both repeatedly revisit the same place at different times, there may still be a significant risk transmission between them. I will identify the areas within the nest that are visited by large numbers of disparate individuals, as it is these popular and public ‘hot spot’ areas that are likely to be critical for the indirect transmission of pathogens. It is important to understand indirect transmission objective will be to develop guidelines for beekeepers so that they may focus hygiene and disease control efforts on these areas.

Keywords: disease transmission,spatial network,movement analysis,self-organisation
Bringing Obesity to Light - Do obesogenic chemicals affect lipid metabolism through changes in circadian rhythm? (OBESITY AND LIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-01-15
End date: 2015-01-14
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

Bringing light to obesity will elucidate the interconnecting steps of two important signaling pathways i.e. circadian signaling and lipid metabolism. An increase in serum cholesterol level in shift workers indicates this link. Also obesogenic chemicals might influence lipid metabolism through changes in circadian rhythm. Research on obesity has gained in importance as the number of affected patients increases world-wide. The WHO lists five European countries in the top 23 states regarding obesity incidence. Moreover, the mounting healthcare costs turn obesity research to a hot topic. With OBELIX and EUCLOCK the EU already funds projects on obesity and circadian rhythm. This proposal joins both topics and links them to toxicology. The main goal is to study the role of circadian rhythm in lipid metabolism and obesogenic effects of chemicals. To elucidate the signaling pathway of environmentally induced obesity the zebrafish a model for genetic and physiological studies will be used. How do alterations in circadian rhythmicity influence lipid metabolism? How do the clock gene rev-erbα and the peroxisome proliferator activated receptors connect circadian and metabolic signaling pathways? Do obesogenic chemicals influence lipid metabolism through changes in circadian rhythm? A multidisciplinary approach will be made using toxicological, physiological, molecular biological and genetic methods in wildtype and transgenic zebrafish larvae and cells. The project will be done at Dr. Juliette Legler’s lab at the Institute of Environmental Studies at the VU University Amsterdam. Dr. Legler already proved to be an expert in ecotoxicological studies in particular regarding obesogenic chemicals. In addition her broad experience in project management and scientific supervision will allow the applicant to reach her scientific goals like enhancing scientific skills and gaining research experience which will be essential to reach professional maturity.

Keywords: natural sciences,obesity,circadian clock,zebrafish,ppar,rev-erba,obesogen
Performance and usefulness of CLImate predictions: Beyond current liMITationS (CLIMITS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 178760.7
EU funding (EUR): 178760.7
Participants: 1
Project status: CLOSED

Over the past 25 years, the modeling community achieved steady progress in dynamical climate predictions, with skill level that is now considered useful for some societal applications at the seasonal time-scale. However, major factors such as coupled models errors, initialization strategies and unconstrained physical parameterizations are still substantially limiting predictability, particularly over land areas. Long-term improvements in climate predictions must necessarily come by (i) improved understanding and description of the physical processes through dedicated process studies and observations. In the meanwhile, (ii) the multi-model approach can be used combining the imperfect models available to enhance predictions. Progresses in both objectives (i) and (ii) need more international collaborative efforts. By implementing collaboration between European and Asian-Pacific climate prediction communities, this project will largely contribute to objective (ii). In fact, five European and seven Asian Pacific climate prediction systems will be collected to form a grand multi-model. The maximum level of multi-model prediction performance currently attainable will be assessed and innovative techniques will be developed in order to evaluate achievable and attained forecast skill over land and the related multi-model capability to enhance usefulness. The project will contribute to objective (i) by improving land surface-vegetation representation in at least one of the multi-model components (i.e: IPRC global climate model). In particular, effort will be made on assessing the impact of improved land surface on simulation and prediction of the Indian summer monsoon (ISM) and then, in turn, on those of Euro-Mediterranean climate during boreal summer, which is related to global teleconnection patterns emanating from the ISM.

Keywords: climate predictability,climate modelling,land surface-climate interactions,multi-model ensembles,forecast value,atmospheric physics