Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart by Design and Intelligent by Architecture for turbine blade fan and structural components systems (SMARTFAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Italy,Italy,Italy,Spain,Italy,Greece,Greece,Belgium,Greece,France,France,United Kingdom,United Kingdom,Portugal,Portugal
Call: Architectured /Advanced material concepts for intelligent bulk material structures (H2020-NMBP-2017-two-stage, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 7989601.25
EU funding (EUR): 7989601.25
Participants: 19
Project status: CLOSED

Smartfan aims at the micro and Nano components, which will be used due to their special physico-chemical properties, in order to develop smart (bulk) materials for final application on intelligent structures. CFs for reinforcement and conductivity variance, CNTs and CNFs for sensing, Micro-containers for self-healing, Electro-Magnetic nanoparticles for fields detection and shielding, colouring agents for marking cracks and defects, piezoelectric materials can be the base for manufacturing new smart materials. In order to develop lightweight composite materials and transfer the properties of smart components into bulk materials polymer based matrices, such as Epoxy, PEEK, PVDF etc., will be used because of their compatibility with the above mentioned components, their low cost and their recyclability/reusability. During synthesis of composite bulk materials several processes should take place in order to preserve the special physico-chemical properties of composites and to achieve the best dispersion in the bulk.

Keywords: smart by design,intelligent by architecture,turbine blade fan,structural components systems
The first B2B marketplace for Fast Moving Consumer Goods, connecting all brand manufacturers and retailers globally (B2BMarketplace)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fast Moving Consumer Goods (FMCGs) are products sold quickly at relatively low prices, like foods, beverages, and toiletries. Most people consume FMCGs every day. Despite the huge size of this market, FMCG producers and retailers experience a number of challenges. First, the need for more product data is continuously growing due to legal and consumer expectations. Second, there is no commonly agreed structure for product information exchange between producers and retailers. Plus, current processes are inadequate for big data exchange, since they are mostly performed manually and, thus, more error-prone. Alkemics has developed a Peer-to-Peer platform to overcome these challenges. B2BMarketplace is the first and unique global B2B marketplace for FMCGs. It connects retailers and producers to sell and buy FMCG goods. It enables producers to get their products discovered by retailers, streamline product data exchange in order to accelerate product launch, and increase the quality of the product content across the retailer ecosystem. At the core of B2BMarketplace lie Alkemics’ unique algorithms which allow the automated product information sharing by translating the inserted ‘raw product data’ into data that is compatible with the common systems used by the stakeholders of the marketplace. Alkemics is a French start-up founded in 2011 and focused on Artificial Intelligence for Big Data exchange. The company is already serving two European key FMCG markets (France and UK) and working with several important retailers (Tesco, Carrefour) and multinational producers (Nestlé, Unilever). It is supported by the recognised GS1 Organisation, which develops global standards for business operations. The proposed work in Phase 1 of the SME Instrument fits into Alkemics' overall plan to reach the market by contributing the financial resources needed to plan a fast, sound deployment of B2BMarketplace.

Keywords: marketplace,fmcg,retailer,producer,platform,taxonomy,product data,gdsn
BIODIVERSITY AND INFRASTRUCTURE SYNERGIES AND OPPORTUNITIES FOR EUROPEAN TRANSPORT NETWORKS (BISON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Israel,Germany,Germany,Italy,Austria,Germany,Spain,Ireland,Germany,Italy,Poland,Romania,Romania,Romania,Slovakia,Slovakia,Sweden,Switzerland,Belgium,Belgium,Sweden,Greece,France,France,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Denmark
Call: Enhancing coordination between Member States' actions in the area of infrastructure research with a particular focus on biodiversity and ameliorating environmental impacts and full automated infrastructure upgrade and maintenance (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 3563652.5
EU funding (EUR): 2999701.25
Participants: 46
Project status: SIGNED

The main objectives of the BISON project are: ● To identify future research and innovation needs for a better integration of biodiversity with infrastructure planning, construction, operation and decommissioning. The project will develop a Strategic Research and Deployment Agenda (SRDA) which can be deployed at multiple scales, within the EU research framework programme, or by other regional, national or local programmes, in order to improve the knowledge-base on infrastructure and biodiversity. ● To make linear infrastructure more high performing and reliable while taking into account the specific needs of Western and Eastern Europe. In Western Europe, there is an increasing need to adapt existing long-lived infrastructure to new climate conditions, as well as finding innovative and sustainable solutions to reduce the impact of invasive species and support declining native species, while in Eastern Europe, there is significant land-use change and habitat fragmentation due to the surge in infrastructure developments to provide economic opportunities that are threatening the local, and very often endemic biodiversity. The project will identify the construction, maintenance and inspection methods and materials which are long-lasting and resilient and can be used by different transport modes to mitigate pressure on biodiversity. ● Support European Member States to fulfill their international commitments by engaging all stakeholders into biodiversity mainstreaming for infrastructure planning and development. It will do so by providing recommendations to minimise the impacts of infrastructure on biodiversity through supporting existing and developing projects. ● Support European Member States to become political leaders through collaboration and support of European research institutions and infrastructure operators, and providing more sustainability at the international level through jointly addressing biodiversity and infrastructure challenges.

Keywords: biodiversity,transport networks,strategic research and development agenda,transport infrastructure
THE EUROPEAN UNION AND ITS NORMATIVE POWER IN A POST-CONFLICT SOCIETY: A CASE STUDY OF NORTHERN KOSOVO (KOSNORTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-09-01
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

This project aims to study the role of normative power of the EU in the post-conflict society of northern Kosovo and to explore how has the signing of the Brussels agreement changed the dynamics of relations at both intra-societal (within the community of Serbs of northern Kosovo) and inter-ethnic level (Serbs of northern Kosovo vs. Kosovo Albanians and the institutions of the Kosovo government). The project would: 1. explore the motivation and driving factors of Kosovo Serbs for their positive/negative stance regarding the signature of the Brussels agreement and the cooperation with the institutions of the Government of Kosovo and Kosovo Albanians in general; 2. assess the intra-societal split within the Serb community in northern Kosovo between those who cooperate with the institutions of the Government of Kosovo and Kosovo Albanians in general, and those who still reject any kind of cooperation, and how is the intra-societal conflict (pressure) manifested; 3. evaluate the impact of normative power of the EU in northern Kosovo; 4. assess the changes in the patterns of relations between Serbs from northern Kosovo and Kosovo Albanians on political, institutional and societal level after the signing of the Brussels agreement; 5. draw policy implications for the EU Common Foreign and Security Policy. This research project draws from three theoretical backgrounds: the theory of normative power, ‘theories’ of peacebuilding, conflict prevention and conflict resolution, and the theory of intra-societal conflict. The following research methods would be applied: interviews, surveying, focus groups (field-work in Kosovo), and study of primary and secondary sources. From theoretical viewpoint, this project is innovative, as it questions the impact of EU’s normative power in a post-conflict society. This project is relevant because certain policy implications (recommendations) for the EU Common Foreign and Security Policy could be drawn from it.

Keywords: kosovo,northern kosovo,inter ethnic relations,intra societal relations,intra societal pressure,conflict prevention,conflict resolution,kosovo serbs,kosovo albanians,brussels agreement
The role of functional redundancy on stability mechanisms in multi-level ecosystem processes face to climatic extremes (SMILE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-16
End date: 2023-09-15
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

The present proposal, SMILE, aims to answer core questions on the current climatic and biodiversity crisis. Together with Dr. Francesco de Bello, a prominent authority on functional ecology and biodiversity, at the CIDE-CSIC, Spain, the applicant, Dr. Felícia M. Fischer, seeks to understand how biodiversity responds to extreme climatic events and how this response affects multiple ecosystem functions. For so, SMILE will explore the role of key aspects of the biological communities in terms of functional traits on the resistance and resilience of natural processes and the provision of multiple ecosystem functions connected to various ecosystem services. Two approaches, one using large-scale datasets of permanent plots, and another, within an extensive biodiversity experiment in controlled conditions, will allow testing the effect of functional redundancy within biological communities (i.e. multiple species with similar ecological functions but different environmental preferences) over the ecological stability (insurance hypothesis). SMILE will rely on cutting edge quantitative methods for accessing and testing the role biodiversity to buffer extreme climatic events. It will also count on a transdisciplinary approach to evaluate multifunctionality, involving the fields of climatology, community ecology, functional ecology, soil biology and biochemistry, carbon and water cycles, among others, with promising applications to conservation. For so, SMILE will involve a large multidisciplinary and multinational collaboration network. Moreover, the project is well aligned with the priorities and themes promoted by the Europe 2020 strategies and the Horizon 2020 program, as it can have important role for restoration of degraded lands, and their maintenance. Communication and dissemination will be, thus, a key priority of the project. The execution of SMILE will be key to enhance the applicant`s career, improving her theoretical, methodological, and overall operational skills.

Keywords: plant ecology,functional ecology,ecosystem ecology,ecological stability,climate change,ecosystem services
Our Mythical Childhood... The Reception of Classical Antiquity in Children’s and Young Adults’ Culture in Response to Regional and Global Challenges (OurMythicalChildhood)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Australia,Israel,Poland,United Kingdom,Cameroon
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1489200.0
EU funding (EUR): 915375.0
Participants: 5
Project status: CLOSED

The project aims at developing a pioneering approach to the reception of Classical Antiquity in children’s and young adults’ contemporary culture. This newly identified research field offers valuable insights into the processes leading to the formation of the culture recipients’ identities along with their initiation into adulthood. However, the most vital potential of this phenomenon remains unexploited, for the research is still selective, focused mainly on Western culture. With my project, I intend to overcome these limitations by applying regional perspectives without the pejorative implication of regional as parochial or inferior. I recognize regions as extremely valuable contexts of the reception of Antiquity, which is not only passively taken in, but also actively reshaped in children’s and young adults’ culture in response to regional and global challenges. Thus, the essence of this innovative approach consists in comparative studies of differing reception models not only across Europe but also America, Australia & New Zealand and – a bold but necessary step – in parts of the world not commonly associated with Graeco-Roman tradition: Africa and Asia. The shared heritage of Classical Antiquity, recently enhanced by the global influence of popular culture (movies, Internet activities, computer games inspired by the classical tradition), gives a unique opportunity – through the reception filter – to gain deeper understanding of the key social, political and cultural transformations underway at various locations. The added value of this original research, carried out by an international team of scholars, will be its extremely broad impact on the frontiers of scholarship, education and culture: we will elaborate a supra-regional survey of classical references, publish a number of analyses of crucial reception cases, and prepare materials on how to use ancient myths in work with disabled children, thus contributing to integration and stimulating cultural exchange.

Keywords: classics,classical reception studies,children s literature,children s culture,young adults literature,young adults culture,classical mythology,ancient greece,ancient rome
Immune checkpoint blockade for fighting Alzheimer’s disease (ImmuneCheckpointsAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 2287500.0
EU funding (EUR): 2287500.0
Participants: 1
Project status: CLOSED

Understanding, and ultimately treating Alzheimer’s disease (AD) is a major need in Western countries. Currently, there is no available treatment to modify the disease. Several pioneering discoveries made by my team, attributing a key role to systemic immunity in brain maintenance and repair, and identifying unique interface between the brain’s borders through which the immune system assists the brain, led us to our recent discovery that transient reduction of systemic immune suppression could modify disease pathology, and reverse cognitive loss in mouse models of AD (Nature Communications, 2015; Nature Medicine, 2016; Science, 2014). This discovery emphasizes that AD is not restricted to the brain, but is associated with systemic immune dysfunction. Thus, the goal of addressing numerous risk factors that go awry in the AD brain, many of which are -as yet- unknown, could be accomplished by immunotherapy, using immune checkpoint blockade directed at the Programmed-death (PD)-1 pathway, to empower the immune system. In this proposal, we will adopt our new experimental paradigm to discover mechanisms through which the immune system supports the brain, and to identify key/novel molecular and cellular processes at various stages of the disease that are responsible for cognitive decline long before neurons are lost, and whose reversal or modification is needed to mitigate AD pathology, and prevent cognitive loss. Achieving our goals requires the multidisciplinary approaches and expertise at our disposal, including state-of-the art immunological, cellular, molecular, and genomic tools. The results will pave the way for developing a novel next-generation immunotherapy, by targeting additional selective immune checkpoint pathways, or identifying a specific immune-based therapeutic target, for prevention and treatment of AD. We expect that our results will help attain the ultimate goal of converting an escalating untreatable disease into a chronic treatable one.

Keywords: immune checkpoint blockade,alzheimer s disease
Identifying new anti-cancer drugs by computational multi-target approaches targeting the Gquadruplex DNA (G4-mtQSAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The goal of the proposed research is to develop computational methodology which can screen out small ligand molecules having potential to selectively target G-quadruplex (G4) DNA which are associated with cancer pathology. Multiple oncogenes and telomerase activity are deregulated in various types of cancers. Ligand induced stabilization of G4s associated with the oncogenes (c-myc, c-kit, k-ras, etc.) and stabilization of telomeric G4s are efficient ways in targeted cancer therapy. Here, we intend to develop multi-target QSAR models that can aid in finding potential multi-target directed ligands (MTDLs) that can stabilize multiple G4s from different oncogenes simultaneously. It is the first computational study for identifying MTDLs against multiple G4s in Cancer treatment. Different multi-target QSAR approaches will be explored including ‘multiple regression and classification’ QSAR models, multi-target QSAR using Box-Jenkins moving average approach and multi-target QSAR using Perturbation approach. Several advanced machine learning techniques will be employed. A state-of-the-art software tool will be developed where all the successful multi-target QSAR models and in-house ADMET models will be incorporated as a knowledgebase. Notably, desirability-based multi-objective optimization approach will be used for identifying drug-like molecules. The software along with in-house KNIME workflows will then be used to screen potential MTDLs against multiple G4s. The selectivity and binding characteristics of the screened MTDLs towards G4s over duplex DNA will be analysed by performing molecular docking and molecular dynamics studies. The binding capacity of the screened MTDLs with intended G4s over duplex DNAs will then be confirmed using experiments such as isothermal fluorescence, UV-Vis, CD spectroscopies and FRET melting assay. The findings will aid in identifying new leads and reducing false positive outcomes in the crucial early stages of drug discovery and development.

Keywords: multi target qsar,cancer,drug discovery,machine learning,computational simulations