Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Industrialisation and Urban Growth from the mid-nineteenth century Ottoman Empire to Contemporary Turkey in a Comparative Perspective, 1850-2000 (UrbanOccupationsOETR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Türkiye,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1497500.0
EU funding (EUR): 1425915.67
Participants: 3
Project status: CLOSED

This project aims to overcome historiographical and disciplinary limitations in social and economic history, historical geography and urban studies for the Ottoman Empire and the Republic of Turkey. The chosen long-term Ottoman/Turkish perspective is intended to facilitate comparative approaches so as to overcome the limitations of national historiographies. By extending the analysis up to 2000 the project also challenges the disciplinary divide between economic history, economics and urban studies in research on Turkey. To pursue these multiple goals the project will adopt both an inter-disciplinary approach and a comparative perspective. Throughout the project the focus will be on the dynamics of industrialisation, urbanisation and their accompanying changes in occupational structures and residential and migration patterns. To be able to contextualise and compare changes in occupational structure and urban growth trajectories across time and space, solid and detailed datasets of occupational structure and historical demographics for a very large part of the Ottoman Empire in the 19th century and for the entire Turkey in the 20th century will be constructed. This project is an attempt at bringing Ottoman/Turkish history into the newly emerging field of digital humanities. It will use advanced techniques of spatial data and multiple correspondence analysis in conjuncture to answer long debated research questions and to formulate and work on new ones by taking an unprecedented step forward toward establishing a digital research infrastructure for the social and economic history of the Ottoman Empire and the Republic of Turkey. This project will re-define industrialisation in its connection with urbanisation from a spatiotemporal analytical perspective for Anatolia and the Southeast Europe to ask time and space specific questions about, simultaneity and geographical convergence of Eurasian economic development since 1850.

Keywords: structural change,economic geography,digital history,historical geographic information system,multiple correspondence analysis,digital research infrastructure
Targeting intracellular proteins and protein-protein interactions with site-specific lipobodies: a new approach for intracellular antibodies (Lipobodies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The RAS family of GTPases is associated with important signalling events responsible for cell growth, proliferation and survival. Mutated RAS are, nevertheless, associated with uncontrolled cell proliferation in 30% of human cancers. Intracellular antibodies targeting oncogenic RAS proteins constitute promising anticancer therapeutics. Nevertheless, their intrinsic cytosolic instability as well as the lack of methods enabling their proper cellular uptake and localization highly limit their use and further development. This proposal describes the multicomponent synthesis of lipidic scaffolds (lipo-TAGs) for the permanent or temporal site-selective lipidation of anti-RAS antibody fragments. Lipidic antibodies (lipobodies) are novel constructs that could share the properties of any lipid-drug conjugate which includes oral bioavailability, enhanced lymphatic/tumour targeting and reduced toxicity. This project also aims to build amphiphilic lipobodies with the ability to experiment cellular uptake and endosomal escape, thus avoiding lysosomal degradation, and eventually experimenting cytosolic processing to generate the active antibody fragment. These unique features will be relevant not only at targeting RAS but any other intracellular protein or protein-protein interaction targets.

Keywords: ras proteins,anti ras antibodies,multicomponent reactions,site selective bioconjugation,lipobodies
Processing and control of novel nanomaterials in packaging, automotive and solar panel processing lines (OptiNanoPro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Italy,Germany,Spain,Ireland,Hungary,Slovenia,Slovenia,Belgium,Hungary,United Kingdom
Call: Integration of novel nano materials into existing production lines (H2020-NMP-PILOTS-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 6920685.0
EU funding (EUR): 5516910.0
Participants: 18
Project status: CLOSED

Nanocomposites are promising for many sectors, as they can make polymers stronger, less water and gas permeable, tune surface properties, add functionalities such as antimicrobial effects. In spite of intensive research activities, significant efforts are still needed to deploy the full potential of nanotechnology in the industry. The main challenge is still obtaining a proper nanostructuring of the nanoparticles, especially when transferring it to industrial scale, further improvements are clearly needed in terms of processing and control. The OptiNanoPro project will develop different approaches for the introduction of nanotechnology into packaging, automotive and photovoltaic materials production lines. In particular, the project will focus on the development and industrial integration of tailored online dispersion and monitoring systems to ensure a constant quality of delivered materials. In terms of improved functionalities, nanotechnology can provide packaging with improved barrier properties as well as repellent properties resulting in easy-to-empty features that will on the one hand reduce wastes at consumer level and, on the other hand, improve their acceptability by recyclers. Likewise, solar panels can be self-cleaning to increase their effectiveness and extend the period between their maintenance and their lifetime by filtering UV light leading to material weathering. In the automotive sector, lightweight parts can be obtained for greater fuel efficiency. To this end, a group of end-user industries from Europe covering the supply and value chain of the 3 target sectors and using a range of converting processes such as coating and lamination, compounding, injection/co-injection and electrospray nanodeposition, supported by selected RTDs and number of technological SMEs, will work together on integrating new nanotechnologies in existing production lines, while also taking into account nanosafety, environmental, productivity and cost-effectiveness issues.

Keywords: nanocomposites,production lines,nanodeposition,electrospray,injection,coating,easy to empty,barrier packaging,self cleaning solar panels,opvs,lightweight automotive parts,nanosafety
A Fully-Implantable MEMS-Based Autonomous Cochlear Implant (FLAMENCO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Türkiye
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1993750.0
EU funding (EUR): 1993750.0
Participants: 1
Project status: CLOSED

Sensorineural impairment, representing the majority of the profound deafness, can be restored using cochlear implants (CIs), which electrically stimulates the auditory nerve to repair hearing in people with severe-to-profound hearing loss. A conventional CI consists of an external microphone, a sound processor, a battery, an RF transceiver pair, and a cochlear electrode. The major drawback of conventional CIs is that, they replace the entire natural hearing mechanism with electronic hearing, even though most parts of the middle ear are operational. Also, the power hungry units such as microphone and RF transceiver cause limitations in continuous access to sound due to battery problems. Besides, damage risk of external components especially if exposed to water and aesthetic concerns are other critical problems. Limited volume of the middle ear is the main obstacle for developing fully implantable CIs. FLAMENCO proposes a fully implantable, autonomous, and low-power CI, exploiting the functional parts of the middle ear and mimicking the hair cells via a set of piezoelectric cantilevers to cover the daily acoustic band. FLAMENCO has a groundbreaking nature as it revolutionizes the operation principle of CIs. The implant has five main units: i) piezoelectric transducers for sound detection and energy harvesting, ii) electronics for signal processing and battery charging, iii) an RF coil for tuning the electronics to allow customization, iv) rechargeable battery, and v) cochlear electrode for neural stimulation. The utilization of internal energy harvesting together with the elimination of continuous RF transmission, microphone, and front-end filters makes this system a perfect candidate for next generation autonomous CIs. In this project, a multi-frequency self-powered implant for in vivo operation will be implemented, and the feasibility will be proven through animal tests.

Keywords: microsystems,mems,biomems,cochlear implant,energy harvesting
Gravitational Waves and Electromagnetic Counterparts from Generic Binary Neutron Star Systems (BNSmergers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-15
End date: 2020-01-14
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The research project will pave the way for a better understanding of the binary neutron star (BNS) merger process with a view on the detection of gravitational waves (GWs) and electromagnetic (EM) signals. To achieve this goal, a large number of numerical relativistic simulations will be used to improve and develop GW models and to compute EM counterparts of BNS mergers. For the first time it is possible to investigate systematically the BNS parameter space, because the total mass, mass-ratio, eccentricity, spin, and the equation of state (EOS) can be varied simultaneously. I will perform numerical simulation of generic BNS systems with the focus on precessing configurations, i.e.~those where the spin of the neutron stars is not aligned with the orbital angular momentum. Based on the numerical simulations, semi-analytical models for the GW signal will be constructed. This is of great importance for GW astronomy, because although a GW from a BNS system may be detected any time in the next years, essential tools needed for the scientific exploitation of such events and determination of the elusive EOS are still missing. In addition to GW modeling, I will compute electromagnetic (EM) counterparts produced during the merger of the two neutron stars. Knowledge about the influence of the binary parameters on the GW and the EM signals allows to combine two independent observational methods, which crucially supports the emergent field of multi-messenger astronomy.

Keywords: neutron stars,gravitational waves,numerical relativity,multimessenger astronomy
INTERACTIONS OF ROOT PHENOTYPES AND ROOT MICROBIOME IN MAIZE UNDER NITROGEN LIMITING CONDITIONS (ROOTPHENOBIOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Plant-associated microorganisms influence plant growth by means of the transformation of nutrients in the root-soil interphase. Nitrogen fertilization is a primary economic and environmental component of intensive maize production. Root phenotypes show a remarkable yet scarcely explored diversity at the architectural and anatomical levels of organization. Such natural variation in root phenotypes has been hypothesized to be related to adaptation under edaphic nutrient stress. The rhizosphere and rhizoplane microenvironments are microbial hotspots that may be influenced by the root phenotype. Contrasting phenotypes may have differences in root exudate localization and oxygen availability, two factors that have important effects on the composition and function of rhizosphere bacteria. In the context of the plant microbiome, previous studies have found effects of planting site, soil properties, compartmentalization (bulk soil, rhizosphere, rhizoplane, endosphere), agricultural management, and fertilization regimes on root-associated microbial communities of agriculturally relevant plants. However, the root phenotype has yet not been evaluated as possible source of variation for the plant-associated microbiome and to link this information with nutrient uptake efficiency. This proposal aims at filling this gap by combining state-of-art root phenotyping, deep molecular genetic assessment of the microbiome, and 15N stable isotope tracing to assess the influence of maize root phenotypes on the root-associated microbiome and its combined effect on fertilizer nitrogen uptake efficiency under low nitrogen availability. Such information will be useful to inform future plant breeding programs targeting root phenes and microbiomes and reduce the reliance on agrochemicals in the context of sustainable agriculture.

Keywords: root phenomics,plant nutrition,microbial ecology,nitrogen
A laboratory study of astronomically relevant large polycyclic aromatic hydrocarbons (GRAND-PAHs) (GRAND-PAHs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The research objective of this proposal is to use complimentary laboratory techniques to study the photo-ionization and photo-dissociation of large (>50 C-atoms) polycyclic aromatic hydrocarbon (PAH) molecules. These molecules are omnipresent in the interstellar medium (ISM) where they are irradiated and electronically excited by ultraviolet photons. This excitation causes PAHs to ionize and/or fragment, contributing substantially to the molecular complexity in space. The underlying chemical pathways are largely unexplored and recent studies show that PAHs play a key role in the formation of i) smaller organic species along a top-down scenario, ii) fullerenes and carbon cages and iii) graphene flakes, i.e., bare PAH skeletons that have not been observed in the ISM yet. These molecules will be studied with a rather unique, fully operational and mobile 'instrument for Photodynamics of PAHs' (i-POP) that is capable of studying the fragmentation of mass selected PAH cations. The mobility of i-POP allows its implementation at different light sources, which include Synchrotron SOLEIL (Saint Aubin - FR) and the free electron laser laboratory FELIX (Nijmegen - NL). The project is timely as its results will actively contribute to European excellence by producing laboratory data relevant to data interpretation from international multi-billion Euro research facilities such as The Atacama Large Millimeter/submillimeter Array (ALMA) and the James Webb Space Telescope (JWST). The training objective is aligned along this research program. The existing expertise in physical chemistry will be extended to the emerging field of astrochemistry and unique knowledge will be obtained through research projects at Synchrotron SOLEIL and FELIX. A secondment is planned in the first year at FELIX to expand my experimental portfolio to include varied irradiation techniques including a free electron laser, to obtain complementary information about astronomically relevant chemical species.

Keywords: astrochemistry,pahs,laboratory astrophysics,photo dissociation
Development of advanced optical tools for studying cellular mechanics at high spatial and temporal resolution (Brillouin4Life)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2026-08-31
Duration (months): 72.0
Total project cost (EUR): 1999289.0
EU funding (EUR): 1999289.0
Participants: 1
Project status: SIGNED

A long-standing aim in the life sciences is to understand development and morphogenesis, i.e. how organismal shape is encoded by the genome and how cellular mechanics are involved in its execution. Lately, investigations have started to focus on the mechanical properties of the involved multicellular compartments, and the interwoven mechanical - molecular interactions at the cellular scale. While molecular components can routinely be visualized with fluorescence microscopy, assessing the mechanical properties of living cells with similar spatio-temporal resolution in a non-invasive fashion has long been an open challenge. Recently, a new type of optical elastography, namely Brillouin microscopy (BM), has emerged as a non-destructive, label- and contact-free technique which can probe visco-elastic properties of materials with diffraction-limited resolution in 3D. Yet, despite ongoing improvements, virtually all current implementations suffer from very low speed, high phototoxicity, and difficulties in quantification, thus prohibiting meaningful investigations in the life sciences. In this interdisciplinary proposal, my group will develop unique and innovative optical imaging technologies based on BM to overcome its current drawbacks and to establish it as a revolutionary tool for live tissue and cellular biophysics studies. In particular, we will work towards a highly-multiplexed BM with selective-plane illumination to maximize speed, resolution and depth penetration, while minimizing photodamage (Aim 1). At the same time, we will combine BM with other imaging modalities that will allow us to obtain correlative datasets and to accurately quantify the measured mechanical properties (Aim 2). We will then apply these methodological advancements together with fellow biologists to study the role of elasticity in tissue morphogenesis and self-organisation, thereby contributing to a better understanding of the role of biomechanics in developmental biology (Aim 3).

Keywords: microscopy,bio imaging,brillouin scattering,mechano biology
Proposal of Consortium AURASME3 for the support services Enhancing the innovation management capacity of SMEs within the Enterprise Europe Network Auvergne-Rhône-Alpes (EURORAA) (AURASME3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 146173.75
EU funding (EUR): 146173.0
Participants: 2
Project status: CLOSED

AURASME3 project is a subset of COSME EURORAA Consortium, based in Auvergne-Rhône-Alpes region France. Partners involved are Partner 1 (coordinator) and partner 2. Partner 3 was not involved in this activity and is inactive since 2015 (amendment). Partner 4 merged with partner 1 (UTRO). The general objective of this proposal is to bridge the gap of lacking innovation management capcities withing international level. The work program is strictly focused on the objectives describes in the call for proposal on the implementation of the two required service package : Key Account Management for beneficiaries of SME Intrument, Fast Track to Innovation; Future and Emerging Technologies Open and Enhancing Innovation Management Capacity. The work programme describes the implementation of these two packages' services, the detailed methodology and process for both service and their expected impact. A close link is maintained with the present EEN COSME related work programme.

Keywords: enhancing innovation management capacity,key account manager,sme intrument,fast track to innovation,future and emerging technologies open