Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Interaction Dynamics of Bacterial Biofilms with Bacteriophages (BIOFAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany,Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-08-31
Duration (months): 68.0
Total project cost (EUR): 1494963.0
EU funding (EUR): 126125.0
Participants: 2
Project status: CLOSED

Biofilms are antibiotic-resistant, sessile bacterial communities that occupy most moist surfaces on Earth and represent a major mode of bacterial life. Another common feature of bacterial life is exposure to viral parasites (termed phages), which are a dominant force in bacterial population control throughout nature. Surprisingly, almost nothing is known about the interactions between biofilm-dwelling bacteria and phages. This proposal is designed to fill this gap using a combination of novel methodology, experimental systems, and mathematical modeling. We have recently developed a new microscopic imaging technique that allows us to image and track all individual cells and their gene expression inside biofilms. First, we will use this technique for tracking the population dynamics of bacteria and phages within biofilms at single cell resolution. By genetically manipulating bacterial hosts and their phages, and by varying environmental conditions, we will investigate the fundamental biological and physical determinants of phage spread within biofilm communities. Second, we will study how biofilms respond to phage attack on both intra-generational and evolutionary time scales, focusing in particular on proximate response mechanisms and the population dynamics of phage-resistant and phage-susceptible cells as a function of biofilm spatial structure. Lastly, we will combine our novel insights to engineer phages that manipulate the composition of biofilm communities, either by subtraction of particular bacterial species or by addition of novel phenotypes to existing biofilm community members. Altogether, the proposed research promises to uncover the major mechanistic and evolutionary elements of biofilm-phage interactions. This combined work will greatly enrich our knowledge of microbial ecology and motivate novel strategies for bacterial biofilm control, an increasingly urgent priority in light of widespread antibiotic resistance.
Optical imaging of retinal function for gene and cell therapies (OPTORETINA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1999720.0
EU funding (EUR): 1999720.0
Participants: 4
Project status: SIGNED

For patients suffering from inherited retinal diseases (IRDs), gene and cell therapies offer hope of preserving or restoring vision. Retinal imaging is crucial, to first phenotype patients to determine which cells are degenerated and devise an appropriate therapeutic path; then in the lab for cell therapy development, and finally back in the clinic to monitor therapeutic success in patients who have been treated with gene or cell therapy. To date, the imaging tools used in the clinic do not provide sufficient resolution for visualizing individual cells non-invasively, constituting a major roadblock for the development of gene and cell therapies. My group develops novel optical imaging tools for noninvasive cellular imaging such as full field optical coherence tomography (FFOCT), an interferometric technique, and adaptive optics ophthalmoscopy (AOO), which corrects ocular aberrations, to achieve diffraction limited resolution of in vivo retina. Recently we also devised a dynamic FFOCT method to detect metabolic contrast using intracellular organelle motion to indicate cell activity. These new noninvasive, all optical tools have the potential to provide, for the first time, simultaneous subjective and objective retinal function measurements. Here, I propose to adapt these existing optical setups based on dynamic FFOCT and AOO to allow retinal stimulation with visible light to enable functional testing of i) patients with IRDs in order to evaluate surviving cells and orient their therapy path; ii) in vitro retinal organoids derived from induced pluripotent stem cells; ii) patients being treated in our clinical centre with novel gene and cell therapies to check that vision is being successfully preserved or restored. The new imaging methods developed here will achieve quantitative functional assessment of cellular activity in vivo and in vitro, lifting the major imaging obstacles for successful application of gene and cell therapies in the clinic.

Keywords: ophthalmology,inherited retinal disease,optical coherence tomography,adaptive optics,scanning laser ophthalmoscopy,gene cell optogenetic therapies,microscopy,live imaging,retinal organoids,optoretinography,perimetry
VISible to far-IR optical tuning: passive DAYtime cooling by hierarchical structures and hybrid materials (VISIRday)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-07-31
Duration (months): 65.0
Total project cost (EUR): 1487636.61
EU funding (EUR): 1487636.61
Participants: 1
Project status: CLOSED

Efficient daytime cooling without the need for a heat engine is an essential technology to lower our overall energy consumption. Nature offers a chance to off-load heat directly into the cold outer space via the so-called “sky window”: a spectral range from 8 – 13 µm, where our atmosphere is transparent. Concomitantly, solar radiance influx needs to be minimized by scattering and reflection, which would counteract the radiatively removed energy. VISIRday aims to provide ground-breaking new materials and concepts to emit thermal energy directly into this transparent sky window. A radically holistic approach is necessary to understand and design the optical properties of nano- and mesostructured materials over the entire spectral range (300 nm – 20 µm), with the mid-IR sky window being fully emissive, and all other spectral wavelengths being fully reflective. I will therefore combine top-down direct write lithography with intricate bottom-up colloidal self-assembly to device hierarchically structured systems fully addressing these stringent optical properties. A new material class – surface phonon polariton supporting nano- and mesoparticles – with adjustable absorption properties in the mid-IR range, will take a leading role as novel colloidal building block. In combination with polymers and metallic nanostructures my team will demonstrate hybrid structures with finely adjusted and even externally tuneable optical properties. Simulations based on finite element modelling to conceive optimum design rules will complement the experimental work. Inspired by examples from nature, namely white beetles and the Saharan silver ant, I will push the fundamental insights towards novel technologies such as radiative daytime cooling paints and fibres. I am convinced that this project provides the urgently needed materials and concepts to add radiative daytime cooling to the existing mix of green energy technologies.

Keywords: optical spectroscopy,hierarchical structures,polymeric materials
AdditiveManufacturABLE (AMable)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Spain,Germany,Spain,Spain,Spain,Cyprus,Switzerland,Greece,Poland,Switzerland,Finland,Belgium,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom
Call: ICT Innovation for Manufacturing SMEs (I4MS) (H2020-FOF-2017, 2017)
Start date: 2017-09-01
End date: 2022-11-30
Duration (months): 63.0
Total project cost (EUR): 8114202.34
EU funding (EUR): 8001358.75
Participants: 24
Project status: SIGNED

EU SMEs/mid-caps face clear barriers in the uptake of Additive Manufacturing (AM) related to lack of skilled human resources, and lack of access to know-how, equipment, infrastructure and markets. The principal objective of this project is to overcome those barriers and enable the uptake of AM technologies by SMEs/mid-caps leading to the development of innovative business and service models and new value-chain models in a fully digital environment – thus bringing their ideas and business cases to life and making their innovations Additively Manufacturable (AMable). To achieve this objective, partners with expertise right across the AM value chain have been brought together from the four corners of the EU to: - create an open-sourced-based, living and adapting AM eco-system which can offer required assistance to European SMEs/mid-caps and become self-sustainable after project execution; - provide all necessary assistance to SMEs/mid-caps allowing successful exploitation of AM, including 3 ‘competitive calls’ for experiments; - offer a comprehensive range of (at least 10) AM support services through an open source- and API-based digital marketplace structured as three Platforms (Technology, Business, and Skills and Education); - support and develop ‘best in class’ AM data handling tools and approaches, on an open-source basis.; - coordinate the development of synergies with the already existing I4MS framework, Competence Centres, Digital Innovation Hubs and other related research and innovation activities at the European level. Through these activities, the following direct impacts are anticipated: - >50 SME/mid-cap application experiments - >150 SME/mid-cap business case evaluations and/or Application Experiments - >500 people trained through AMable approved courses - >2,000 SMEs/mid-caps reached through training, roadshow and exhibition events - specific support for EU-13 countries, with >5 centres supported and coached

Keywords: additive manufacturing,blockchain,industrial dataspace
Smart Monitoring COntrol and User interactive ecosystem for improving energy efficiency and economic maintenance of Medium-WeighT Ships (SCOUT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Opportunity: Shipping emissions are expected to double by 2050, as are the related social and environmental effects. The cost of fuel has become a major expense item for every company in the transportation business, possibly more so for Tugboats, Ferries, Dredges, Off-Shore, because their engines (and fuel tanks) are disproportionately large. This situation has force regulators, to act consequently and force operators to implement continues monitoring & efficient solutions Added value proposal: SCOUT provides a Smart Monitoring & COntrol and User interactive ecosystem for improving energy efficiency and economic maintenance of Medium-WeighT Ships, taking advantage of the above opportunity presented by the necessity and recent regulations, of monitoring and reducing emissions, as well as, the economic need of saving costs in terms of fuel combustion and maintenance of medium-weight ships market, by delivering three key market applications: (i) Upgraded consuming knowledge; (ii) Greater engine performance (estimated from 10% to 20%) (iii) Longer ship life (reduction of 10-25% of operational costs) Phase 1 objectives is to accelerate the market adoption and international penetration of SCOUT focus on preparing ourselves for the commercialization of at the international level (including route-to-market, marketing strategy, growth strategy, etc.) by evolving the product from TRL6 to TRL9 stage Impact : As a result of this project, SCOUT will grow considerably, generating 73 new qualified jobs by five years after the project ending and generating cumulative incomes of 63.7M€ and a EBITDA of 35.7M€ approx (56% of margin)

Keywords: efficient shipping,training on board
5G Exchange (5GEx)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Italy,Italy,Germany,Ireland,Greece,Hungary,Sweden,Norway,Norway,France,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-10-01
End date: 2018-06-30
Duration (months): 33.0
Total project cost (EUR): 10003725.0
EU funding (EUR): 7921094.88
Participants: 20
Project status: CLOSED

The goal of the 5G Exchange (5GEx) project is to enable cross-domain orchestration of services over multiple administrations or over multi-domain single administrations. This will allow end-to-end network and service elements to mix in multi-vendor, heterogeneous technology and resource environments. Market fragmentation has resulted in a multitude of network operators each focused on different countries and regions. This makes it difficult to create infrastructure services spanning multiple countries, such as virtual connectivity or compute resources, as no single operator has a footprint everywhere. 5GEx aims to enable collaboration between operators, regarding 5G infrastructure services, with the view to introducing a unification via NFV/SDN compatible multi-domain orchestration by producing (i) an open platform enabling cross-domain orchestration of services over these multiple domains, with a set of open source software tools and extensions that can be utilised outside the scope of 5GEx; (ii) a Sandbox Network enabling experimentation and validation of the devised architecture, mechanisms, and business models; (iii) a proof-of-innovation multi-domain platform enabling multiple 5G use-cases and realistic scenarios that demonstrate the orchestration of complex end-to-end Infrastructure as a Service across multiple carriers; (iv) contributions to standards bodies of concepts learned during the development and experimentation of the project; (v) input to stimulate the telecom and IT industry stakeholders by actively promoting adoption of 5GEx’s open solutions. Such 5G infrastructure services will provide a crucial role in making 5G happen as they provide the foundation of all cloud and networking services. 5GEx aims to enable, through operator collaboration, a unified European infrastructure service market integrating multiple operators and technologies, where service provisioning is fast and automated and which results in stronger economy via economies of scale.

Keywords: multi domain,multi operator,orchestration,cloud services
Distributed, integrated and harmonised forest information for bioeconomy outlooks (DIABOLO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Ukraine,Germany,Spain,Spain,Ireland,Estonia,Ireland,Austria,Austria,Germany,Germany,Italy,Austria,Serbia,Belgium,Greece,Lithuania,Sweden,Switzerland,Norway,Hungary,Romania,Slovakia,Slovenia,Finland,Latvia,France,France,Czechia,Denmark,Portugal,United Kingdom
Call: Improved forest data (H2020-ISIB-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 4998970.0
EU funding (EUR): 4734594.5
Participants: 37
Project status: CLOSED

Europe’s bioeconomy is expected to foster economic growth and to tackle significant societal challenges with less harmful environmental effects through innovative, sustainable and inclusive use of European forest resources. Increasing demand for biomass and other ecosystem goods and services calls for changes in forest-related policies at different levels and across different sectors. Accordingly, the recent Forest Strategy provides clear signals towards the need for harmonised information for mapping and assessing the dynamic state of forest ecosystems and their services. Building upon scientific advances in COST E4, 39, 43, USEWOOD, FORSYS, ORCHESTRA; the networks ENFIN, EFFIS, SOSIN; the FP7 EUFODOS, S2BIOM, INTEGRAL, SIMWOOD, FIRE PARADOX the project DIABOLO aims to: i) strengthen the methodological framework towards more accurate, harmonised and timely forest information, e.g. on growing stock and stock changes, biomass, carbon, NWFP; enable the analysis of sustainable biomass supply derived from multipurpose and multisource national forest inventories; and facilitate near real-time forest disturbance monitoring, e.g. on forest fires, storm, drought, insect outbreaks; ii) support EU policy processes, international reporting obligations, forest administration and forest planning entities with new methodologies and EU-wide consistent forest information; iii) make innovative use of existing field-collected data and EC space-based applications of EO and satellite positioning systems with reference to INSPIRE and GEOSS, and global monitoring systems such as REDD+, FLEGT and UNFF. To deliver high impact, beyond state-of-the-art work within the ecological and socio-economic diversity in Europe, the trans-disciplinary DIABOLO involves experts in quantitative modelling, policy science and NFIs, from 26 European countries, committed to provide new methodologies and information for various end-uses, including EFDAC (FISE) at JRC, GLOBIOM at IIASA and work at FAO/UNECE.

Keywords: harmonised forest information,bioeconomy outlooks,national forest inventories,monitoring,disturbances,sustainable forest management,data products,eu policies,earth observation
MARKET ENABLING INTERFACE TO UNLOCK FLEXIBILITY SOLUTIONS FOR COST-EFFECTIVE MANAGEMENT OF SMARTER DISTRIBUTION GRIDS (EUniversal)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Cyprus,Belgium,Belgium,Belgium,Belgium,Poland,Belgium,Poland,Norway,Belgium,Poland,United Kingdom,Portugal,Portugal
Call: Flexibility and retail market options for the distribution grid (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2020-02-01
End date: 2023-11-30
Duration (months): 46.0
Total project cost (EUR): 9787076.88
EU funding (EUR): 7999997.5
Participants: 24
Project status: SIGNED

The present context shows the potential of electricity grids to lead the energy system transition as long as new solutions deal with the challenges related to flexibility solutions, grid observability and controllability, market mechanisms and interoperability in a holistic way. The new solutions need to cover the technological aspects by linking smart and integrated services and tools for distribution grid with market mechanisms. This architecture will guarantee a significant impact on the environment and society. The project consortium accepted this challenge and will develop “EUniversal Project” which will enable the transformation of the electricity grid by resolving existing limitations in the energy system through the introduction of a Universal Market Enabling Interface (UMEI). Through this concept, grids will become capable of accommodating all future scenarios through the active use of grid services, acting as an extensive toolbox of flexibility solutions and innovate market mechanisms. The primary goal of EUniversal is to enable the transformation of the energy system into a new multi-energy and multi-consumer concept guaranteeing a sustainable, secure and stable manner of electricity supply by bringing forward an universal, adaptable and modular approach through a Universal Market Enabling Interface (UMEI) to interlink active system management with electricity markets and the provision of flexibility services, taking also into consideration the activation needs and the coordination requirements with both commercial parties and TSOs. To do so, EUniversal will define, develop and validate a set of market-oriented flexibility management services from DER in a real environment, under a large RES integration and high electrification scenario. In order to demonstrate the services generated in the development phase of the project, 3 different DEMO sites (located in Portugal (PT), Germany (DE) and Poland (PL)) will be run to validate the project solutions.

Keywords: distribution grid,interoperability,market mechanisms,grid observability,flexibility,grid services,interface,energy transition,multi consumer,energy networks,demo,umei,renewable energy