Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fibrin sealant for anastomotic leaks and haemostasis (sFilm-FS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Israel
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 2003388.0
EU funding (EUR): 1402371.6
Participants: 1
Project status: CLOSED

Sealantium Medical Ltd is developing a novel product, sFilm-FS, a bio-compatible bio-absorbable, polymeric film embedded with lyophilized Human Fibrinogen, Human Thrombin and calcium chloride. This novel product aimed to help controlling body fluid leakage in general surgery procedures, proposing its use as an adjunct to hemostasis and/or sealing. sFilm-FS is intended to be used for soft tissue bleeding during surgeries, when control of bleeding by standard surgical methods of hemostasis (suture, ligature, cautery) is ineffective or impractical. sFilm-FS is also intended for use as adjunct to sealing in gastrointestinal anastomosis procedures for prevention of leakage following intestinal anastomosis. sFilm-FS is a combination product based on a degradable, bio-compatible non-permeable polymeric film that contains biological components which serve as a glue fixing the film to its target tissue. Unlike other products which contain similar components, sFilm-FS primary mode of action is based on the sealing capacity of the polymeric film. sFilm-FS was tested in rat and pig models demonstrating high safety profile and effective hemostatic and sealing capabilities. The product was absorbed after two weeks without any side effects allowing perfect healing of the injured tissue. The objective of the project is to continue the development of the product to a stage which demonstrates the safety and efficacy of the product in phase I/II human clinical trials, including GMP manufacturing upscale. sFilm–FS will make surgical procedures shorter by preventing surgical complications, saving time, efforts and risks taken by the medical staff. sFilm-FS will also significantly improve the prognosis and outcome of various surgical procedures by preventing complications related to post-surgical bleeding or anastomotic leakage. The commercial potential in the project is large as it provides better solutions for hemostasis and a paradigm shifting solution for anastomotic leaks.

Keywords: fibrin sealant,fibrinogen,thrombin,hemostasis,anastomotic leaks,general surgery,gastrointestinal tract,bio degradable,manufacturing scale up,clinical trials
Quantifying the impact of major cultural transitions on marine ecosystem functioning and biodiversity (SEACHANGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Australia,Norway,Denmark,United Kingdom,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 11750827.0
EU funding (EUR): 11750827.0
Participants: 6
Project status: SIGNED

The seas are changing. Marine conservation seeks to protect valuable habitats but the pristine state of marine ecosystem functioning and biodiversity – that is, the system as it operated before there was any large scale human impact – is conjectural. Conservation management strategies are often based on highly altered ecosystems where the degree of human-induced change is unknown. In SEACHANGE, we propose a structured and systematic approach to the reconstruction of marine ecosystem baselines to quantify the impact of anthropogenic cultural transitions on marine biodiversity and ecosystem functioning. SEACHANGE will address two key questions: 1) What was the nature of long-term changes in prehistoric marine biodiversity and ecosystem functioning over a 3000-year period in NW Europe and the degree of human impact associated with major socioeconomic changes across the Mesolithic-Neolithic boundary? 2) What has been the scale and rate of marine biodiversity loss and changes to ecosystem functioning as a result of fishing intensity and marine habitat loss during the last 2000 years (including the Industrial Transition) in the North Sea and around Iceland, eastern Australia and the west Antarctic Peninsula? To address these questions we will analyse: 1) absolutely-dated annually-resolved bivalve shell series (“sclerochronologies”); 2) marine sediment cores; 3) archaeological midden (waste) materials including shells and bones. We will date these samples precisely and undertake zooarchaeological and palaeoecological, stable isotope geochemical and environmental DNA/DNA metabarcoding analyses. We will compare the data with historical and archival sources, and we will generate numerical ecosystem simulations. We will identify how depleted the current marine environment is compared with that before large scale human impact and what measures are needed, and how long will it take, for marine biodiversity to recover.

Keywords: marine palaeoevironments,holocene,marine ecosystems,marine biodiversity,environmental change,cultural transition,sclerochronology,marine environmental archaeology,midden
Framing sand sustainability in a telecoupled world (SANDLINKS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 248425.92
EU funding (EUR): 248425.92
Participants: 2
Project status: CLOSED

Global raw material extraction grew by 94% between 1980 and 2010 to reach a total of 70 Bt per year in 2010, and is predicted to reach 100 Bt by 2030. Sand and gravel are the most extracted group of materials worldwide. The construction industry is behind this huge demand. Sand is critical for concrete, land-reclamation projects or combating coastal erosion. Despite enormous advances being made to understand and quantify the footprint of human infrastructure, the “off-site” impacts derived from the provision of construction minerals are largely ignored. An ever-increasing demand for these resources is putting more and more strain on limited deposits, which has led to conflicts around the world and will likely lead to a “tragedy of the sand commons” if sustainable mining cannot be achieved. The project aims to understand how an increasing demand for sand affects complex human-nature dynamics and connects with environmental and sustainability challenges through mining, transportation, trade and consumption. I will apply and operationalize a systems integration approach, the telecoupling framework, and conduct studies at multiple scales to strengthen the knowledge base and contribute to develop possible pathways into a sustainable management and governance of construction minerals. This research will combine research methods such as evidence synthesis, material flow analysis and agent-based modeling. The research is proposed as a 3-year GF. MSU will be my host during the outgoing phase in USA and I will be hosted at UCL in Belgium during the third year. The MSCA will allow me to consolidate my transition to this field and become a pioneer in the application of an integrated perspective to address the environmental and socioeconomic interlinkages resulting from sand supply and demand. This research has great potential for scientific advancement and it will open up the best career possibilities for my career and new collaboration opportunities for the host organisations.

Keywords: sustainability sciences,mining,construction minerals
Microdosimetry study of a new radiation therapy method based on proton minibeams (u-PBeam)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Radiotherapy (RT) is the medical use of ionising radiation to treat cancer. The main challenge is to deposit a high enough (curative) dose in the tumor while risk organs near the tumour remain at tolerable doses. About 52% of cancer patients receive RT at least once during treatment. The RT has achieved great success in the cure or palliation of various cancers, but for improving this statistic, new treatment modalities as proton radiotherapy (PT) are rapidly expanding. PT achieves very high dose conformity around the target, allowing a better protection of the organs at risk (decreasing radiation side effect). However, using PT the dose delivered to a tumour is still conditioned by the dose that can be tolerated by the surrounding normal tissues. This is particularly critical for certain types of radioresistant tumours, such as hypoxic tumors, for those localized near organs at risk or sensitive structures (e.g. the spinal cord), and paediatrics cancers. For these types of cancers with poor prognosis it is imperative to find new RT approaches that reduce the normal tissue complication probability (NTCP). A recent novel therapy aim to increase the effective dose therapies by using a distinct dose delivery method based on proton minibeams (pMBRT). To implement this promising technique at clinical centers, microdosimetric data are required on the radiation quality aspects of proton minibeams to take advantage of their enhanced relative biological effectiveness versus conventional radiotherapy sources. Currently there are only one array of microdosimeters, as the proposed herein, capable of measuring these parameters in proton therapy. This is the challenge where a candidate approach is preferred.

Keywords: protontherapy,microdosimetr a,new radiation therapies,oncology,cancer research,radiation,detectors,microtechnology,monte carlo simulations
New Distributed Optical Fibre Sensors For Future IoT Society (DIFFUSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Poland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 140100.0
EU funding (EUR): 140100.0
Participants: 1
Project status: CLOSED

The main objective is to boost the company’s innovation capacity by conducting research on new optical fibre distributed sensors. This requires development of the specialised skillset within the company on optical fibre phenomena such as Rayleigh, Raman, Brillouin, and Coherent Rayleigh scattering. Hence the main goal is to overcome barriers of recruitment of highly specialised researcher and to recruit the specialist, who will be an initiator of the innovation potential growth in InPhoTech The idea of the optical fibre distributed sensors follows a global trend in the global market for sensors and is a direct answer to the number of inquiries addressed to InPhoTech. The optical fibre distributed sensors allow to monitor critical infrastructure and manufacturing processes. Within the project we answer the European and global demand for reliable optical fibre sensing system, driven by need of connecting more and more sensors into IoT (Internet of Things), integration and miniaturisation of sensors, as well as the demand for accurate and early diagnosis devices in an effort to increase safety in industry.

Keywords: optical fibres,photonic,optical fibre sensors,highly qualified researcher recruitment
Deciphering virus-host interactions using correlated confocal-atomic force microscopy (NanoVirus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1998125.0
EU funding (EUR): 1998125.0
Participants: 1
Project status: CLOSED

Viruses are a major class of pathogens that infect a variety of organisms. Infection is a multistep process that involves the concerted action of both virus and host cell machineries. The first steps of virus infection include cell binding, cell entry and release of the viral genetic material. Entry pathways are largely defined by the preliminary interactions between viruses and their receptors at the cell surface. Those interactions determine the mechanisms of virus attachment, uptake, and, ultimately, penetration into the cytosol. Elucidating the complex interplay between viruses and their receptors at the cell surface is an essential step towards establishing a full picture of the infection process. Currently, a crucial challenge in virology is to develop a quantitative method to decipher the entry pathways of a virus, thus allowing the probing of the kinetics and energetic parameters of the interactions established between the virus and the cell surface. While current methods successfully describe the entry pathways, they fail in identifying in a quantitative manner the key steps such as energy intensive and high-affinity steps. To overcome this limitation, the ambition of this ERC proposal is to combine the latest generations of atomic force microscopes (AFM) with confocal laser scanning microscopes (CLSM). This will allow us to investigate and quantitatively characterize the early steps of single virus entry directly on living cells. At the frontiers of nanotechnology, biophysics and biology, this project aims at pushing the limits of AFM to enable us to better understand the molecular mechanisms of virus entry. This project will have strong scientific and medical impacts. In virology, it will significantly improve the understanding of the mechanisms of virus infection. In medicine, the new method will help us and other researchers to screen new compounds that are targeting viral infection.
Network for effective knowledge transfer on safe and economic wastewater reuse in agriculture in Europe (SuWaNu Europe)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Spain,Italy,Spain,Italy,Israel,Germany,Germany,Italy,Spain,Cyprus,Bulgaria,Greece,Belgium,France,Portugal,Portugal
Call: Thematic networks compiling knowledge ready for practice (H2020-RUR-2018-1, 2018)
Start date: 2019-01-01
End date: 2021-06-30
Duration (months): 30.0
Total project cost (EUR): 1999926.25
EU funding (EUR): 1999926.25
Participants: 20
Project status: CLOSED

Reclaimed water has a strong potential for complementing conventional water resources. According to the European Commission communication “Closing the loop - An EU action plan for the Circular Economy” (COM(2015)0614): “in addition to water-efficiency measures, the reuse of treated wastewater in safe and cost-effective conditions is a valuable but under-used means of increasing water supply and alleviating pressure on over-exploited water resources in the EU”. Water reuse is especially relevant in agriculture as this is one of the main water consumers, having additional benefits for farmers: lower cost compared to other solutions (e.g. desalination), reliability of supply regardless of season, climatic conditions and associated water restrictions, and nutrients contribution of the treated wastewater that can supplement or replace conventional fertilizers. Based on the results of a previous EU project called SuWaNu (contract number 319998) whose main result was to set research driven clusters in the field of water reuse in 5 target countries: Malta, Spain, Germany, Greece and Bulgaria, SuWaNu Europe is intended to bridge the current innovation gaps and achieve an effective implementation of reuse solutions in agriculture. SuWaNu Europe will extend the geographical coverage of its predecessor and will summarize, share and present existing and upcoming knowledge and skills in the field of water reuse in agriculture to the relevant stakeholders such as farmers and farming advisory groups. SuWaNu Europe will also create regional working groups for the development of action plans. These action plans will set strategies at regional level with the objective of boosting innovation in the agricultural and water sectors, improving best practice development and identifying the most appropriate channels to reach stakeholders. In addition to this, dissemination and training will create the capacity and competencies needed to implement these results.

Keywords: water resue agriculture,circular economy,rural developement,sustainable water management,practicioners,multi actor approach,networking
Advanced wireless system for predictive monitoring of structural wind turbine components (eolACC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wind energy plants are increasingly becoming critical parts of electrical infrastructure around the world. Despite major technological advancements over the past decade, an estimated 5.500 wind turbine blades fail each year, resulting in long periods of unexpected downtime and repair costs. At eologix sensor technologies gmbh, we are developing an advanced system called eolACC that uses wireless accelerometers to detect damage to blades before they fail. The patented sensor technology is thin and flexible, allowing it to be easily applied to virtually any location, even on aerodynamic surfaces of blades. Together with a base station and our software, diagnostics will alert operators of poor blade conditions and thus enhance their ability to plan critical maintenance activities. Additionally, the insight from blade sensors will help operators manage assets more effectively, and make objective decisions about useful lifetimes and operating ranges. eolACC builds off of an ice detection system previously made by eologix by utilizing the same sensor profile, wireless data transmission, and ambient light power system. Initially eolACC will be sold to owners and operators of wind plants, and in the future we will pursue collaboration with large wind turbine manufacturers. The eolACC system will ultimately help wind power plants to operate more efficiently by reducing unexpected downtime. Owners and operators will be able to more effectively plan budgets and maximize the lifetime of their assets.

Keywords: wind,turbine,diagnostics,sensor,blade,acceleration,accelerometer,energy,software,maintenance,monitoring,downtime,outage,optimize
Hexatic hydrodynamics: from driven soft matter to biological tissues (HexaTissue)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1897018.0
EU funding (EUR): 1897018.0
Participants: 1
Project status: SIGNED

How do hexatics flow? Forty years after Nelson’s and Halperin’s first prediction of the existence of this phase of two-dimensional matter, intermediate between crystalline solid and isotropic liquid, this seemingly elementary question is still unanswered. Whereas the delicate nature of hexatics could partially justify this oversight, recent findings in tissue mechanics have created the urgent demand to fill this gap, by providing this phase with unexpected biological relevance. Like two-dimensional crystals on the verge of melting, tissues are often neither ordered solids nor disordered liquids, but inhabit a continuum of intermediate states known as the epithelial-mesenchymal spectrum. This versatility lies at the heart of a myriad of processes that are instrumental for life, such as embryonic morphogenesis and wound healing, but also of life-threatening conditions, such as metastatic cancer. Understanding the physical origin of these mechanisms requires going beyond the current hydrodynamic theories of complex fluids and introducing a new theoretical paradigm, able to account for hexatic order and biomechanical activity. This multidisciplinary program aims to develop a systematic theory of hexatic hydrodynamics and use it to gain insight into the physical mechanisms underpinning the dynamics of tissues and the progression of metastatic cancer. The program will consist of three themes. First we will develop the necessary formalism to describe viscous flow in hexatics. Next, we will extend it to tissues and investigate the interplay between hexatic order, activity, topological defects and flow. Finally, we will use the new framework to explore the first three steps of the metastatic cascade: 1) the detachment of clusters of mesenchymal cells from the primary tumour; 2) their subsequent invasion of the extracellular matrix; and 3) their translocation across blood vessels, which allows metastases to enter into the bloodstream and disseminate to distant organs.

Keywords: hexatic,liquid crystals,active matter,tissues,cancer,metastasis