Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cytokine and microbiota function in gut development: spatiotemporal analysis in the zebrafish (Cytok-Gut)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Organ development and function are controlled by complex interactions between genetic, cellular, and environmental factors. Because these interactions are challenging to study in live organisms, their mechanisms remain largely unknown. Gut development is regulated by microbiota colonization, making it a valuable organ for dissecting gene-environment interactions. Cytokines, small secreted proteins highly responsive to environmental changes, regulate immunity and gut function in mammals. Our data indicate that specific cytokines are also essential for gut development in zebrafish. We found that these cytokines are first expressed in gut epithelial cells during development, and later their expression is switched to immune cells, including innate lymphoid cells (ILCs). ILCs were discovered in the mammalian gut but their function has not been dissected due to the lack of specific markers. Having identified the first vertebrate ILC markers in zebrafish, we will combine our novel tools together with other unique benefits of zebrafish such as live microscopy, easy environmental manipulation and abundant genetic tools, to dissect how microbial cues interact with genetic networks to control organ development. We hypothesize that gut development is regulated by cytokine signaling that is, in turn, regulated by crosstalk with the microbiota, and the emergence of ILCs. Our specific aims are to: 1. Characterize the roles of cytokines during gut development 2. Determine how microbiota-cytokine crosstalk controls gut development 3. Uncover the role of ILCs and cytokine source switching in gut maturation This project, at the intersection of developmental biology and immunology, will provide fundamental insights into how symbiont-host crosstalk controls organogenesis, and a new conceptual framework for the function of the immune system. Furthermore, conservation with the human gut could help identify new therapeutic strategies for common diseases such as inflammatory bowel disease

Keywords: cytokines,intestinal epithelial cells,microbiota,innate lymphoid cells,zebrafish
Buddhism, Diplomacy, and Travel: Identity- and Nation-Building in Bhutan (BhutIdBuddh)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

This research project is an investigation of identity- and nation-building in eighteenth-century Bhutan with a particular focus on the agency of Buddhist masters as important diplomats and Bhutan's entangled history with Tibet. This will enable a novel understanding of Bhutan's religious and political history, particularly its Buddhism-induced development model of Gross National Happiness (GNH) that has not yet received systematic historical analysis in religious studies in Europe despite its global popularity as an example of alternative sustainable economic models. Furthermore, for the first time, Bhutan's historical role in linking South Asia, the British Raj, and East Asia will be systematically addressed. The research output will significantly advance both fields - that of Tibetology and religious studies. The innovative research design combines historical-philological methods by analyzing a thus far untranslated corpus of Bhutanese/Tibetan primary sources with a theoretical framework from religious studies focusing on identity and social differentiation. Therefore, the project is in its methodology, output, and impact inter-disciplinary. The researcher will produce a draft for a single monograph publication for habilitation in Germany. The proposed project involves as the researcher a German Tibetologist trained in Germany, Canada, India, and Bhutan reintegrating to Germany to work with a religious/Buddhist studies scholar at Leipzig University. This will enable substantial training for the researcher in religious studies and impactful two-way knowledge exchange between the researcher and the host institution due to the international experience of the researcher. An intersectional secondment at The British Library Endangered Archives Programme (London) will provide further Tibetological training in (digital) archival work, palaeography, and codicology, and produce globally accessible research data about this digitized Bhutanese/Tibetan primary source corpus.

Keywords: buddhism,religious studies,tibetology,identity,nation building,agency,modernity,asia,bhutan,himalaya,gross national happiness,entangled history,secularity,social differentiation
Multiresponsive optoelectronic devices based on multicomponent transition metal dichalcogenide networks (MODERN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

MODERN will offer a highly skilled young researcher with a PhD in chemistry and an outstanding track record a top-quality training through research in the cross-disciplinary, supra-sectoral field of printed multifunctional 2D semiconductors. Transition metal dichalcogenides (TMDs) are revolutionary 2D materials with ultrathin thicknesses and intriguing optoelectronic properties, which are promising alternatives to Si technologies for miniaturized devices thereby extending Moore’s law. TMD inks can be printed into large-area thin films, yet comprising vdW gaps and random defects which significantly hinder charge transport. While molecular functionalization can improve charge transport, most studies focused on single-component TMDs or molecules with a single functionality, missing the potential of supramolecular chemistry to engineer the performance and functionalities of next-generation optoelectronic devices based on 2D materials. MODERN aims to develop covalently linked multicomponent TMD networks with adjustable properties and enhanced performance by molecular engineering for multi-responsive optoelectronic devices. These networks with tunable components, including transition metal disulfides, diselenides, and ditellurides, will be fabricated by covalently linking solution-processed TMD nanosheets in thin films via defect engineering to passivate defects and improve charge transport. Further chemical functionalization with selected functional molecules responding to external stimuli will add responsive capabilities to the multicomponent TMD networks. Photoswitchable optoelectronic devices with enhanced charge transport and switchable photoresponsiveness will be fabricated (responsive transistors, multi-level memories). MODERN will promote the practical application of molecularly functionalized TMD networks in miniaturized optoelectronic devices. MODERN’s ultimate goal is to prepare the fellow for a leadership position in academia or industry in Europe.

Keywords: two dimensional materials,transition metal dichalcogenides,2d material networks,supramolecular chemistry,chemical functionalization,optoelectronic devices,photosensitive networks
ADDING LEARNING TECHNOLOGY AND HOSPITAL DATA TO FLUTE (ALTO-FLUTE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Romania
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 452500.0
EU funding (EUR): 452500.0
Participants: 2
Project status: SIGNED

The recently started FLUTE project aims to research and develop a platform for secure, privacy-preserving cross-border federated learning, and includes a pilot study on the diagnosis of prostate cancer. While FLUTE's algorithms will scale well to larger number of patients, it does not include work towards handling very large models, and its pilot study has a limited size of about 3500 patients. In the ALTO-FLUTE project, Siemens Romania (SR) will bring (a) a large dataset with 500 million medical images among which 100.000 prostate MRI images and 12.000 prostate MRI images with diagnosed cancer, and (b) significant expertise in training large-scale foundational models which can exploit not only the more expensive fully labelled data but also the more abundant unlabelled data or incomplete patient records. Supported by the existing partners, SR will be integrated in the FLUTE project, will learn new privacy-enhancing technology, will research and develop new secure, privacy-preserving algorithms, and will add extensive new contributions to the pilot study. This effort will significantly enhance FLUTE's impact, and will stimulate the exchange of scientific knowledge and ideas between Romanian researchers and participants of excellent research projects.

Keywords: federated learning,privacy enhancing technologies,secure multiparty computation,differential privacy,homomorphic encryption,privacy metrics,gdpr,privacy preserving cross border learning
Reconfigurable intelligent surfaces-based energy harvesting sustainable wireless communication systems. (RISESWCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: TERMINATED

The essential role of digital technologies in modern society together with the profound changes introduced are reflected in the second “Digital Agenda for Europe: 2020-2030” which is focused on radically improving digital infrastructure and providing ubiquitous public services by 2030 through gigabit connectivity in a low cost manner. This project considers low cost reconfigurable intelligent surfaces based energy harvesting sustainable wireless communication system (RISESWCS) for substantially improving the physical layer and medium access layer performance of the future wireless communication systems. Moreover, this project will provide a practical feasibility study for employing low cost RISs as a radio access network technology for a large scale wireless powered communication network with wideband transmissions. The project will systematically begin with the analysis, optimization of the RISESWCS at the physical layer and provide the performance analysis and optimization techniques for improving the data rate, coverage and energy efficiency at the physical layer. In this step, the practical aspect of the project will be ensured by carrying out the analysis and optimization by incorporating the realistic scenario into the system model which include imperfection in the channel state information, centralized overhead information unavailability and dependence of the reflecting angles in RIS elements on impinging frequencies. Then, the research will be extended to incorporate the medium access layer (MAC) for providing a holistic view for the large RISESWCS. In particular, MAC layer techniques, in terms of resource block allocations, scheduling and routing mechanisms, will be developed while considering the requirements of 6G wireless networks in terms of different fundamental performance metrics of MAC layer such as collision probability, packet loss and delay. Finally, the project will summarize the feasibility conditions for deploying RISESWCS in a real scenario.

Keywords: reconfigurable intelligent surface,radio frequency energy harvesting,wireless communication systems
Unravelling the Nitrogen Fixation-Primary Production Feedback Loop: Implications for Carbon Cycling and Oceanic Health (NIPROFEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

The project ‘NIPROFEED’ delves into the vital interplay between primary producers, nitrogen fixation, and particle dynamics in aquatic ecosystems. Primary producers play a crucial role in capturing roughly one third of excess carbon dioxide and converting it into organic particles, central to the ocean's biological pump. This process, however, contributes to oxygen depletion as sinking particles lead to organic matter respiration and subsequent deoxygenation of bottom waters. Diazotrophs, specialised microbes capable of nitrogen fixation, provide a significant portion of nitrogen input into oceans, supporting primary production. NIPROFEED introduces the hypothesis that diazotrophs supplying nitrogen to primary producers can amplify particle formation, initiating a positive feedback loop that impacts carbon export and oxygen levels. To explore this feedback loop, NIPROFEED will employ cutting-edge techniques, including high-throughput sequencing, single-cell rate measurements and biogeochemical modelling. This will unravel the composition and functional role of free-living and particle-bound diazotrophs, shedding light on their contribution to nitrogen/carbon fixation. By implementing these parameters into an integrated model the intricate relationship between nitrogen fixation and primary productivity will be investigated. Addressing this hypothesis, NIPROFEED aspires not only contribute significantly to scientific advancements in the field of marine science but also aligns with EU sustainability goals by shedding light on climate change impacts on our ocean.

Keywords: nitrogen fixation,diazotrophs
Skills - Predicting, Understanding, and Locating Shortages in Europe (SkillsPULSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Estonia,Poland,Ireland,Greece,Finland,United Kingdom
Call: Tackling European skills and labour shortages (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 2666250.0
EU funding (EUR): 2666250.0
Participants: 8
Project status: SIGNED

The study will address significant gaps in the understanding of skills deficiencies in Europe – i.e. the extent, causes, and implications of skills shortages and skills gaps. Skills shortages refer to where employers face difficulties recruiting people from the external labour market because applicants lack the skills, qualifications, or experience sought. Skills gaps refer to the extent to which organisations’ workforces lack the skills required to meet their business goals. There is a tendency to think that skills shortages and skills gaps will disappear over the medium to long term, so they do not require policy interventions. The evidence suggests otherwise. Shortages and gaps do not clear quickly enough, certainly from a policy-making perspective, with negative consequences for individual workers, companies, and, in aggregate, the economy as a whole. This has the potential to damage organisational performance and productivity. It is thus important to measure skills shortages and gaps, locate where they arise (or are anticipated to arise) with respect to jobs, sectors, and countries affected, and analyse their causes and means of mitigation. The study will provide a conceptual review of skills shortages and gaps, and devise a means of measuring their incidence and the extent to which they are likely to arise in the future as a consequence of key changes in the economy (notably digitalisation). The study will provide a methodology for identifying the extent, causes, and implications of skills deficiencies in Europe. A series of indicators will be devised, including a Skills Shortage Index, which can be incorporated in a software tool for use by those responsible for labour market skills intelligence at national and pan-European level. The tool will be road-tested by working with those responsible for producing labour market skills intelligence at national level to develop something that provides a valuable addition to that already produced.

Keywords: skills gaps,skills shortages,methodological framework,big data analysis,skills shortage index,labour market skills intelligence,software tool
Surgical optogenetic bioprinting of engineered cardiac muscle (LIGHTHEART)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1499705.0
EU funding (EUR): 1499705.0
Participants: 1
Project status: SIGNED

Heart failure remains a leading cause of mortality worldwide taking an estimate of 16 million lives each year. Cardiac tissue engineering solutions that can improve the quality of life of those with advanced heart disease have proved challenging so far. Bioprinting is an exciting technology that holds promise to fabricate tissues and organs. Lab-grown engineered cardiac muscle requires at least four weeks to maturate in a bioreactor. In LIGHTHEART, an off-the-shelf solution will be developed for treating injured myocardium in vivo. An unconventional combination of bioprinting and optogenetics will be used to surgically fabricate engineered cardiac muscle directly at the patient’s heart. A surgical bioprinting tool will be constructed to achieve vascularization and cellular architectures as that observed in native cardiac muscle. Induced pluripotent stem cell-derived cardiac cells will be the basis of the bioinspired biomaterial-free ink that will be printed. Optogenetic expression of different light-sensitive proteins at the cell surfaces will be the sole trigger of cellular assembly, thus omitting the need to embed cells in hydrogels or printing in a supporting bath. Surgical optogenetic bioprinting will be first tested ex vivo using a silicone human phantom with a mimicking beating heart, and later in vivo in a large animal model in accordance with the 3R principles. LIGHTHEART opens up new horizons in the way heart failure can be clinically treated and brings hope to patients who are desperately waiting for a heart transplantation. The disruptive nature of LIGHTHEART will unite engineers, surgeons and scientists to change the future of transplantation medicine with modular bottom-up technologies that allow for in vivo tissue and organ restoration or replacement directly at the operating theatre.

Keywords: in vivo bioprinting optogenetics tissue engineering cardiac muscle heart failure
Reconstruction and Unification of Neural and Ecological Systems (RUNES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1996580.0
EU funding (EUR): 1996580.0
Participants: 1
Project status: SIGNED

In the last two decades, network science has revolutionized our understanding of diverse biological, social, and technological systems, becoming a cornerstone across various scientific and technological domains. Traditional network models, however, predominantly focus on pairwise interactions, often overlooking the complexity of higher-order interactions (HOIs) that involve more than two elements. This oversight is significant, as emerging evidence increasingly demonstrates that HOIs are not only prevalent but also critically influence the emergent behaviors of complex systems, thereby impacting our ability to comprehend and forecast their dynamics. RUNES aims to pioneer a novel paradigm in network science, tailored to the intricacies of higher-order systems. This project will develop a holistic mathematical, methodological, and empirical framework to effectively understand, predict, and manipulate HOIs. This will involve redefining existing network models to incorporate higher-order interactions, combining information-theoretic and topological perspectives, and formulating new dynamical processes on these advanced substrates. Concurrently, RUNES will innovate in developing model-informed statistical methods for inferring HOIs from data, enabling us to discern their unique structures and functions. This framework will be applied in two groundbreaking contexts: firstly, in experimental behavioral science, where we will quantify the impact of HOIs in controlled human group experiments; secondly, in neuroscience, where we will investigate the higher-order functional topology of the brain across various conditions, ages, and species. RUNES’ new science of higher-order real-world complex systems will directly impact how we think about and deal with structural and dynamical patterns in many contexts, including epidemiology, artificial intelligence, economy and medicine.

Keywords: topological data analysis,higher order networks,computational modeling,group interactions,neuro ecology,neural architectures,functional brain connectivity