Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reducing required sample size of new studies by effectively using historical data: new methods for evaluating mechanisms, conditions, and alternative explanations (Data Synthesis Power)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Scientists, organizations, and governments are moving in the direction of sharing their data. This will lead to an unprecedented amount of available data that researchers could use as prior information in a Bayesian analysis. While Bayesian methods are a promising method for using the growing amount of available information to increase statistical power in research studies, there is a great need for developing guidelines for calibrating existing data to create accurate informative prior distributions. Bayesian methods that incorporate accurate prior information in the statistical analysis reduce the required sample size of the new study without decreasing the chance of detecting a true effect. However, prior data may be from a different population, measured using different instruments, and/or collected using different experimental procedures than those in the current study. Using the results from a prior study that differs from the current study in any of these respects as prior information in a Bayesian analysis can lead to biased results. Several promising calibration methods have been proposed for linear regression analysis. In this project I will extend and test these methods to models with third variables that reveal the conditions under which an effect exists (moderators), the mechanism through which one variable affects another (mediators), and variables that might explain an observed effect (confounders). I will develop guidelines and tools for social science researchers in numerous fields ranging from psychology and pedagogics to education and epidemiology for proper calibration of data from previous studies when evaluating the conditions under which an effect exists, the mechanism through which one variable affects another, and alternative explanations for an observed effect. These calibration methods will reduce required sample sizes in new studies, thus reducing required funds for data collection, and the burden on the researchers and participants.

Keywords: data synthesis methodology,bayesian,small samples,clinical psychology,data sharing
Pleiotropy and Evolutionary Constraint (PLEVOCON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-09-20
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

When organisms adapt to new environments, are the genetic mechanisms that underlie evolutionary trajectories predictable or stochastic? Recently, genomic studies have provided tantalizing clues that the genetic mechanisms that underlie evolutionary trajectories may be more constrained and deterministic than previously thought. Theoretical work has suggested that pleiotropy, or the influence of a single gene on multiple traits, might be an important deterministic factor during adaptive evolution. Specifically, high levels of pleiotropy are predicted to decrease the frequency with which a locus is used over the course of evolution because it is much more likely that mutations in that locus will have negative fitness consequences. Despite these theoretical predictions, however, we lack explicit tests of how pleiotropy contributes to evolutionary predictability. The objective of the PLEVOCON project is to test whether pleiotropy is a source of evolutionary constraint that underlies the predictability of evolutionary responses. The threespine stickleback (Gasterosteus aculeatus) is an ideal system in which to test whether pleiotropy is a source of evolutionary constraint. Crucially, these small fish have independently and repeatedly adapted to diverse freshwater habitats in the northern hemisphere since the retreat of the glaciers 12,000 years ago. Stickleback living in similar habitats have evolved similar phenotypes, providing an opportunity to ask whether the same genes underlie adaptation to these habitats, and whether genes that are repeatedly used for adaptation have lower levels of pleiotropy. I will utilize the existing wealth of genetic and genomic resources in this system and develop innovative statistical approaches to carry out the first genome-wide test of whether pleiotropy is a source of constraint in evolutionary responses.

Keywords: adaptive evolution,natural selection,population genomics
Assessing the effect of diagenesis on dateable materials: implications for the chronology of the Levantine Middle Palaeolithic (DIACHRON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 173464.32
EU funding (EUR): 173464.32
Participants: 1
Project status: CLOSED

The Levant is a key area to study past human dynamics: due to its strategic position, connecting Africa to Europe and Asia, it has been the main route of the most ancient dispersals of modern humans out of Africa and a privileged environment for Neanderthal occupation. This project is focused on improving the chronology of Middle Palaeolithic sites in Israel using a comparative approach based on independent dating methods such as electron spin resonance of tooth enamel, thermoluminescence of burnt flint and luminescence of sediments. Their application requires in-depth knowledge of the preservation state of the sample and its macro- and micro-sedimentary contexts, which might affect the accuracy and the resolution of the chronological data. This comparative approach will take into account the impact of diagenetic processes on both dateable materials and sedimentary context. Characterisation methods (e.g., Fourier transform infrared and Raman spectroscopy) will be applied prior to dating in order to assess the degree of alteration and evaluate its effect on age determinations. The DIACHRON project will be hosted in one of the world’s leading multidisciplinary research institutions, the Weizmann Institute of Science. It will be implemented at the Kimmel Center for Archaeological Science, which has been home to the development of sample and context characterisation. The chronological aspect of the project will benefit from the collaboration with the partner institution, the Geological Survey of Israel, which is internationally recognised in luminescence dating. Open access publications, participation to conferences and science outreach activities will be the core of the dissemination strategy. The training provided will integrate the researcher in the field of material characterisation and would contribute to developing a unique interdisciplinary profile combining the knowledge of several dating methods, with clear benefits for the career development of the fellow.

Keywords: chronology,diagenesis,electron spin resonance,luminescence,middle palaeolithic,neanderthal,homo sapiens,levant
A mood-indexed database of scores, lyrics, musical excerpts, vector-based 3D animations, and dance video recordings (MUSICAL-MOODS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-01
End date: 2019-04-02
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

The project aims at the development of an online database of scores, lyrics and musical excerpts, vector-based 3D animations, and dance video recordings, indexed by mood. Such a taxonomy of relations between the musical, linguistic and motion domains will be aimed at interactive music systems and music making. For realising the database, digital scores inclusive of lyrics will be gathered from collections of music in the public domain. Music mood classification using audio and metadata will aim at capturing sophisticated features but using no explicit domain-specific knowledge about a mental state. Datasets will be realised through a cross-modal approach. Validation of the model will be carried out by combining results from an online game-with-a-purpose, for Internet users, and from intermedia case studies for selected dancers. In further case studies, music works will be realised, also by invited artists, for the evaluation of the database in interactive music making. An online call for artists to use the database in music making or sound generation will be aimed at extending the evaluation further. The final database will be made available online for further exploitation. The present research will generate new knowledge for use in next-generation systems of interactive music and music emotion recognition, also contributing to extend the investigation in the broader areas of music making, computational creativity and information retrieval.

Keywords: mood database interactive music emotion recognition language processing audio classification prediction metadata scores lyrics dance motion capture video creativity retrieval public domain
Ensygnia Onescan Market Disruptive Technology (odis)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 10477921.25
EU funding (EUR): 500000.0
Participants: 1
Project status: CLOSED

Ensygnia Onescan Open Disruptive Innovation Scheme If awarded the €500,000 grant, Ensygnia would use it to accelerate the company’s market disruption activity in Europe. This would involve expansion by hiring key Business Development and Sales Executives to engage with target companies across Europe and increase awareness Ensygnia’s Onescan platform and App. Onescan’s patented process will fuel the uptake of mobile payments and also has applications for transaction authentication and logon services. Onescan introduces new levels of enhanced security coupled with ease of use factors which have the power to revolutionise the payments landscape. Ensygnia’s progress so far has already been recognised within the mobile and payments industries: • Mobile Industry Awards: “Best Software Solution” – Ensygnia [June 2014] • UK winner in the “Innotribe start up” challenge 2014 organised by SWIFT – the banking industry group. We will now take part in the global Innotribe finals in Boston later this year • Voted by the audience at the Mobile World Congress as one of the top three companies most likely to have “the greatest impact on the global mobile industry over the next ten years” (March 2013) In Europe, Ensygnia will first look to target Spain, Germany, and France. We have both a direct and an indirect customer acquisition strategy. We are targeting companies with large customer bases so will work with key partners where necessary but can also deal direct. We aim to create an eco-system of consumers able to use the Onescan App to make payments online and in-stores anywhere in Europe and beyond. Onescan securely associates identity with transactional information – both personal and financial - and has the power to disrupt traditional methods of payment, and other vertical market applications, on a global scale.

Keywords: market disruptive technology
The Janus-face of the localized carrier in cuprates: Generating the pseudogap and high temperature superconductivity (TheONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Austria,Croatia
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2133950.0
EU funding (EUR): 1734375.0
Participants: 2
Project status: SIGNED

The phenomenon of high-temperature (high-Tc) superconductivity (SC) is one of the most exciting, thoroughly investigated yet still unresolved problems in physics. A major difficulty in understanding high-Tc systems lies in the complexity of the materials and phase diagram. The delicate balance between material specific properties, disorder and the number of electronic phases superimpose makes it hard to identify the leading interactions. Consequently, theoretical models attempting to describe the high-Tc SC are significantly disparate and identifying the mechanism of SC at elevated temperatures is full of hardship. Due to the proximity of the antiferromagnetic phase, the strong electronic interactions, the appearance of a pseudogap etc., the electronic phase is considered to be exotic, a non-Fermi Liquid and the coupling mechanism for Cooper pairs strange. Based on my recent experiments, here I propose a change of paradigm: •that the charge carriers which couple to give high temperature superconductivity follow the well-known Fermi-liquid behavior •that the pseudogap phenomenon corresponds to a gradual (Mott-like) localization of exactly ONE charge carrier per unit cell •the “Glue” for pairing stems from a bosonic excitation of ONE localized carrier leading to a novel excitonic mechanism for SC. These hypotheses will be tested primarily on the model compound Hg1201, which features a simple tetragonal structure, minimal disorder effects, and the highest Tc in its class of single-layer compounds. Fermi-liquid aspects will be probed by novel approaches to (magneto)transport, optical conductivity. The relation between SC and The ONE will be explored by unique experimental setups that combine uniaxial-pressure with local/structural probes. If the above conjectures are indeed confirmed it would give an enormous boost to this field. Beyond finding the solution of a 30-year-old enigma, it would enable an educated search for new materials with potentially even higher Tc's.

Keywords: high tc cuprates,pseudogap,mott localization,fermi liquid,excitonic superconductivity,uniaxial pressure,local probes,optical conductivity,transport,quantum oscillations
Technology Advances and Key Enablers for Module Integration for 5 nm (TAKEMI5)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Germany,Israel,Germany,Germany,Italy,Belgium,Hungary,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands
Call: ECSEL Key Applications and Essential Technologies (IA) (H2020-ECSEL-2016-2-IA-two-stage, 2016)
Start date: 2017-04-01
End date: 2019-11-30
Duration (months): 32.0
Total project cost (EUR): 132778302.32
EU funding (EUR): 28339999.24
Participants: 26
Project status: CLOSED

In line with industry needs, Moore’s law, scaling in ITRS 2013/2015, and ECSEL JU MASP 2016, the main objective of the TAKEMI5 project is to discover, develop and demonstrate lithographic, metrology, process and integration technologies enabling module integration for the 5 nm node. This is planned with available EUV/NA0.33 scanners that are optimized for mix and match with existing DUV/NA1.35 scanners, and with system design and development of a new hyper NA EUV lithography tool to enable more single exposure patterning at 5 nm to create complex integrated circuits. Process steps for modules in Front-end, Middle and Back-end of line are discovered and developed using the most advanced tool capabilities and they are evaluated morphologically and electrically using a relaxed test vehicle. During the development, specific challenges in metrology are assessed and metrology tools are upgraded or newly developed. The results are demonstrated in the imec pilot line with qualified metrology tools at the 5 nm node. The TAKEMI5 project relates to the ECSEL work program topic Process technologies – More Moore. It addresses and targets, as set out in the MASP, at a (disruptive) new Semiconductor Process, Equipment and Materials solutions for advanced CMOS processes that enable the module integration of electronic devices for the 5nm node in high-volume manufacturing and fast prototyping. The project touches the core of the continuation of Moore’s law which has celebrated its 50th anniversary. The cost aware development process supports the involved companies, and places them in an enhanced position for their worldwide competition. Through their worldwide affiliations, the impact of the TAKEMI5 project will be felt outside Europe in America and Asia Pacific semiconductor centers and is expected to benefit the European economy a lot by supporting its semiconductor equipment and metrology sectors with innovations, exports and employment.

Keywords: semiconductor process,equipment and materials
Circuit analysis of thalamic visual processing and its modulation by long-range projections (Thalamic Circuits)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2020-04-01
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The thalamus, whose anatomical history goes back two millenia, has long been recognized as the master relay for sensory information propagating to cortex and consciousness. Yet, it is indisputable that thalamic nuclei are much more than simple relays but integrate different sensory modalities, bottom-up as well as top-down information. One elementary form of top-down modulation is attention, which selectively enhances behaviorally relevant information. Attentional modulation occurs already at the thalamus by, yet, unresolved circuit mechanisms. My research specifically aims at (1) exploring circuits for long-range, top-down modulation of thalamic visual processing, (2) dissecting the circuitry underlying attentional modulation, and (3) understanding basic rules of thalamic information processing. I will pursuit these three aims using an innovative combination of monosynaptic retrograde rabies tracing, optogenetics and deep 2-photon calcium imaging. My experiments will focus on the lateral geniculate nucleus (LGN), which is the main connection between the optic nerve and the visual cortex, as well as on the thalamic reticular nucleus (TRN), which provides major inhibitory input to LGN and has previously been implicated in attentional regulation. Notably, TRN deficits have been suggested to contribute to the clinical symptoms of schizophrenia. By rabies tracing, I will target channelrhodopsin to monosynaptic long-range inputs to the visual thalamus. By GRIN-lens assisted 2-photon imaging I will quantify visual responses and search for signatures of attentional modulation that can be induced by optogenetic stimulation of specific inputs. This approach will allow me to quantify attentional modulation of thalamic information-processing by specific long-range inputs, to dissect the underlying circuitry mechanisms and to contribute to a better understanding of thalamic computational power as well as its vulnerabilities.

Keywords: neural circuits,vision,thalamus,attention,in vivo imaging
FogsScreen Mini - breakthrough laminar air purification technology with stunning interactive images (FOGSCREEN MINI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FogScreen Mini is a unique home and office air purifying device that projects stunning interactive images onto a screen of vapour. It uses breakthrough laminar circulation technology to purify and humidify an entire room more effectively and quietly than current devices. The purified air stream creates a curtain of fog, which is used to present responsive hologram-like images for entertainment or promotion. By adding visuals to air sanitation, the FogScreen Mini will stimulate the large-scale take-up of air quality technology, improving the health of residents and office workers in polluted urban environments worldwide. The demand for indoor air purification systems is growing rapidly due to poor urban air quality, resulting in respiratory problems and general poor health. All existing purifiers use turbulent circulation, which is ineffective and noisy. FogScreen Mini is pioneering laminar air flow technology, which distributes clean air and captures particles more effectively. Tests show the FogScreen Mini collects at least 25% more particles and is 50% quieter than the nearest competitor. Customers are residents and office managers seeking to improve air quality. The market for air filtration technology is estimated to reach $US20.65B by 2020. The company will partner with electronics manufacturers. One Chinese distributor is already in negotiations. Fogio has already created a prototype unit, proven the technical concept and shown quantifiable benefits. It holds worldwide patents for the innovation. The company has a team of 11 experienced professionals, including technology experts to develop innovations, and a sales team with international networks. Within five years, Fogio forecasts total unit sales of 2.8 million, generating €790 million in revenue, scaling up to 300 employees. The benefits for Europe will be improved citizen health and reduced deaths from respiratory problems.