Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Standarization and orthogonalization of the gene expression flow for robust engineering of NTN (new-to-nature) biological properties. (ST-FLOW)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Switzerland,United Kingdom,Portugal,France,Spain,Germany,Spain,Austria,Germany,United Kingdom
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 7770001.2
EU funding (EUR): 5998742.0
Participants: 15
Project status: CLOSED

The ST-FLOW Project merges the efforts of 14 leading European research groups for developing material and computational standards that enable the forward-design of prokaryotic systems with a degree of robustness and predictability that is not possible with customary Genetic Engineering. The central issue at stake is the identification and implementation of rules that allow the conversion of given biological parts assembled with a set of principles for physical composition into perfectly predictable functional properties of the resulting devices, modules and entire systems. ST-FLOW focuses on each of the steps that go from assembling a DNA sequence encoding all necessary expression signals in a prokaryotic host (by default, E. coli) all the way to the making of the final product or to the behaviour of single cells and populations. Two complementary approaches will be adopted to solve the conundrum of physical composition vs. biological functionality of thereby engineered devices. In one case (bottom up), large combinatorial libraries of gene expression signals will be merged with suitable reporter systems and the input/output functions examined and parameterized in a high-throughput fashion. The expected outcome of this effort is to establish experience-based but still reliable rules and criteria for the assembly of new devices and systems -following the same physical composition rules or adopting CAD design. Yet, many outliers (combinations that do not follow the rules) are expected, and making sense of them will be the task of the complementary top-down approach. In this case, ST-FLOW will revisit some of gaps in our knowledge of the gene expression flow (transcription, mRNA fate, translation) that need to be addressed for engineering functional devices from first principles. Ethical, legal and societal issues will also be examined in a context of public dialogue and sound science communication.

Keywords: transcription factories,parameterization,orthogonalization,pops,biobricks,synbis system,cad
Long-term effects of early nutrition on later health (EARLYNUTRITION)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Germany,United Kingdom,Austria,Denmark,Spain,United Kingdom,Norway,Ireland,Netherlands,Spain,Netherlands,United Kingdom,Spain,Poland,United Kingdom,Ireland,Italy,Greece,Belgium,Austria,Netherlands,Netherlands,Spain,United States,Australia,Belgium,Germany
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-02-01
End date: 2017-10-31
Duration (months): 69.0
Total project cost (EUR): 11597678.02
EU funding (EUR): 8962771.0
Participants: 40
Project status: CLOSED

Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 individuals to investigate: • The fuel mediated in utero hypothesis • The accelerated postnatal weight gain hypothesis • The mismatch hypothesis. Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level, and refined strategies for intervention in pregnancy and early post natal life to prevent obesity. Using existing cohort studies, ongoing and novel intervention studies and a basic science programme, we will provide the scientific foundations for evidence based recommendations for optimal EarlyNutrition that incorporate long-term health outcomes, focusing on 4 Target Groups: women before pregnancy; pregnant women; infants (incl. breastfeeding); young children. Evidence is produced from animal and placental studies (Theme 1; T1), prospective cohort studies (T2), and randomised controlled trials in pregnant women and infants (T3). T4 covers scientific strategic integration, recommendation development and dissemination, including systematic reviews and behaviour change approaches. A strong multi-disciplinary team of international leaders in the field including collaborators from USA and Australia achieves balance and complementarity. The project’s impact comprises definitive evidence on early nutrition effects on health, enhanced EU and global policies, major economic benefits through obesity prevention and value-added nutritional products, and practical recommendations on optimal nutrition in Target Groups. Wide dissemination will be achieved through active engagement with stakeholders.

Keywords: metabolic programming of adult health,obesity prevention,maternal nutrition,infant nutrition
Streamlining bio-research in Australia, Canada, New Zealand and the United States with Europe through multilateral cooperation activities (BIO TRIANGLE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Other activities
Action type: Coordination and support actions
Countries involved: Italy,Austria,Greece,Hungary
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2011-12-01
End date: 2014-11-30
Duration (months): 36.0
Total project cost (EUR): 1729292.0
EU funding (EUR): 1499929.0
Participants: 5
Project status: CLOSED

BIO TRIANGLE brings together the leaders in BIO-research from Europe and four industrialised Third Countries – which together form a imaginary TRIANGLE around our globe. The project’s objective is to foster scientific and technological cooperation in the Knowledge-Based Bio Economy (KBBE) between Europe and Australia, Canada, New Zealand and the United States. It builds upon two important, ongoing initiatives: the EU-US Task Force on biotechnology, and the International KBBE Forum, involving the EU, Australia, Canada and New Zealand. The planned activities include the organisation of: i) priority setting workshops and policy dialogue fora, ii) a multilateral roundtable to coordinate related initiatives, such as INCONETs and BILAT projects, iii) ‘twinning’ activities between projects in the EU and partner countries, including an online information exchange platform, iv) working visits of high-level researchers & summer schools for early-stage researchers, to and from the EU and partner countries. In addition, information will be disseminated through a website and promotion materials, and via related networks and initiatives. The expected impacts of BIO TRIANGLE are: strengthened cooperation amongst all partner countries, both at the policy-making and the researcher level; greater awareness amongst researchers of the possibilities, benefits and best-practices of bilateral and multilateral S&T cooperation; and increased exchange of knowledge and skills that support the further development of KBBE.

Keywords: workshop,twinning,exchange of researchers,joint training programmes,kbbe,international cooperation
Advanced multifunctional forest management in European mountain ranges (ARANGE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Austria,Switzerland,France,Germany,Sweden,Slovenia,Slovakia,Bulgaria,Spain,Finland,Austria,Czechia,Netherlands
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-02-01
End date: 2015-07-31
Duration (months): 42.0
Total project cost (EUR): 3802775.79
EU funding (EUR): 2991077.0
Participants: 16
Project status: CLOSED

The sustainable provision of ecosystem services (ES) in and from mountain regions is of crucial importance to an array of stakeholders and society in general, going much beyond the interests of particular landowners in the mountain regions themselves. Mountain ecosystems can only continue to provide all these services in a rapidly changing world if a wide array of ES is considered in forest management at local, landscape and regional scales (multi-functionality). The project builds on seven case study regions in major mountain ranges throughout Europe covering a wide range of forest types, socio-economic conditions and cultural contexts and seeks to develop and evaluate strategies for their multifunctional management considering risks and uncertainty due to changing climatic and socio-economic conditions. The project addresses four main ES: timber production, protection against gravitational natural hazards, the role of forests in climate change mitigation via carbon sequestration as well as bioenergy production, and nature conservation and the maintenance of biodiversity. Non-timber forest products, recreation as well as use of forested landscapes by game and livestock species will be dealt with as well. To analyse conflicts and comple¬mentarities among ES from stand to landscape scales, improved models for the assessment and projection of ecosystem services as well as novel planning and decision support tools will be developed together with SMEs and applied in the case study regions. Stakeholder panels in all study regions will inform research activities and contribute to the development of improved mountain forest management approaches. SME partners play a key role in the development of new planning tools. Ultimately, ARANGE will translate project findings on the efficient provision of multiple ES from mountain forests into decision support for policy makers and forest practitioners, so as to improve the robustness of planning tools in real-world decision making.

Keywords: multi-functionality,ecosystem services,natural hazards,climate change,forest management,models,planning,stakeholder participation,decision support systems
Learning about Interacting Networks in Climate (LINC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Germany,Israel,Netherlands,Uruguay,Spain,Germany,Netherlands
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 3715523.97
EU funding (EUR): 3715523.97
Participants: 9
Project status: CLOSED

Improving our understanding of the Earth’s climate phenomena, such as El Niño, has a huge economic and social impact for present and future generations, and can underpin advances in areas as diverse as energy, environment, agricultural, etc. There is a great shortage of qualified workforce to perform this task and a major challenge is the training of qualified researchers that can approach climate phenomena from a complex systems point of view. The ITN proposed here, ‘Learning about Interacting Networks in Climate’ (LINC) aims to address these issues by training 12 ESRs and 3 ERs in the complete set of skills required to undertake a career in physics and geosciences with expertise in climatology, networks and complex systems. We will combine recent advances in network methodologies with state-of-the-art climate understanding. The consortium, comprising of 6 academic partners, 3 SMEs and one associate partner (also an SME) is in an excellent position to impart these skills, with expertise ranging from complex systems (network construction, nonlinear time series analysis), and environment and geosciences (nonlinear processes in the oceans and atmosphere) up to commercial applications (climate risk analysis, using climate networks to predict extreme events). The skills to be imparted in each of the 5 WPs (Network Construction and Analysis, Interacting Networks, Natural Climate Variability, Future Climate Change, and Tipping Points in the Climate System) can be applied across a wide range of interdisciplinary fields. In LINC the training of researchers will be aided by secondments at the commercial partners’ premises, a series of workshops, schools and a conference. The strong commitment towards training and research of the partners will guarantee graduates with full interdisciplinary capabilities, that will allow them to significantly advance the present knowledge of climate phenomena, and which will provide them a wide-range of career opportunities.

Keywords: complex systems,complex networks,network theory,climatology,environmental science,nonlinear dynamics,physics of ocean and atmosphere,time series analysis,tipping points,climate change
Broadening the Bioinformatics Infrastructure to unicellular, animal, and plant science (ALLBIO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Coordination and support actions
Countries involved: Sweden,Netherlands,Switzerland,United Kingdom,Italy,Finland,Belgium,Sweden,Germany,Germany
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2011-10-01
End date: 2014-09-30
Duration (months): 36.0
Total project cost (EUR): 1120050.0
EU funding (EUR): 999915.0
Participants: 10
Project status: CLOSED

The main aim of AllBio will be the coordination of the partner's activities that are aimed at the extension of a large number of bioinformatics facilities towards applicability in target life science areas beyond human health. Bioinformatics facilities developed for the human health area will be extensively tested on unicellular (incl. bacterial), plant and (farm) animal genomes, and they will be tightly integrated in the wider frame-work of Elixir infrastructure activities. AllBio will develop a coordinated action plan for the harvest of the information from 'omics' data related to other species than Homo sapiens.

Keywords: bioinformatics,plant genomics,animal genomics,bacterial genomics
Enhancing biomass production from marginal lands with perennial grasses (GRASSMARGINS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Ireland,Ireland,Sweden,Denmark,China,Denmark,United Kingdom,Germany,Russian Federation,Poland
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2011-10-01
End date: 2015-09-30
Duration (months): 48.0
Total project cost (EUR): 3932138.12
EU funding (EUR): 2998623.0
Participants: 12
Project status: CLOSED

Perennial grasses, which once established can be harvested and re-grow annually for many decades, have a number of other beneficial characteristics which suit them as biomass crops. These include high resource use efficiency, high productivity, good environmental qualities and a wide range of end uses. Environmental benefits include high rates of soil carbon sequestration, enhanced biodiversity and soil stabilisation. Furthermore, perennial grasses naturally colonise marginal areas of land which often impose severe restrictions on the growth of vegetation. Marginal land is defined as land of poor quality for agriculture and which yields poor returns for the farmer. The aim of this project is to identify, characterize and develop novel varieties of C3 grasses (Dactylis glomerata, Festuca arundinacea and Phalaris arundinacea) and the C4 genus Miscanthus that show high and stable productivity and require the minimum of additional inputs when grown on different forms of marginal land. In broad terms the work will contribute to overcoming specific bottlenecks along the whole perennial grass-based production chain. In particular it will use modelling to identify the optimal characteristics and geographical distribution of perennial grasses of potential use for biomass production, undertake pre-breeding of novel varieties, investigate stress tolerance and develop drying characteristics following harvest. The consortium assembled to achieve these outputs consists of 12 partners from eight countries representing Northern, Central and Western Europe and partners from Russia and China and involves three SME partners.

Keywords: c3 grass,c4 grass,miscanthus,cocksfoot,dactylis glomerata,tall fescue,festuca arundinacea,reed canary grass,phalaris arundinacea,marginal land,stress,salt,drought,flooding,pre-breeding
A Flexible Sustainable Active and Intelligent Packaging Technology Platform Enabling Enhanced Shelf Life, Quality and Safety of Fresh Food Produce (ISA-PACK)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,United Kingdom,Spain,United Kingdom,Germany,Belgium,United Kingdom,Poland,Spain
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 3929784.4
EU funding (EUR): 2999946.0
Participants: 10
Project status: CLOSED

ISA-Pack will develop a flexible sustainable, active and intelligent technology platform for the packaging of fresh food produce, targeting extended shelf life and quality, enhanced safety and reduced food and packaging waste. Whilst suitable for a wide range of foods, ISA-Pack will validate the resulting materials and technologies for modified atmosphere and stretch wrap packaging of fresh beef steaks. Key objectives include: - to develop novel unsaturated polyhydroxybutyrate copolymer materials derived from microbial fermentation of sustainable feedstocks and incorporating low volume cross linkages, demonstrating enhanced properties suitable for high performance gas barrier and stretch film packaging applications; - to identify synergistic combinations of active food preservation chemistries that may be covalently bound (grafted) within polymeric materials using reactive extrusion techniques; resulting in high efficacy active packaging materials, impacting minimally on food organoleptic properties, ensuring compliance with food ingredient / migration limits; and demonstrating extended food shelf life and quality and improved safety; - to develop an accurate, tuneable and reliable intelligent indicator system that may be directly printed onto packaging materials (cost efficiency), combining integrated time temperature indicators (microbe growth) with lipid oxidation indicators (freshness), thereby providing assurances of food shelf life, safety and quality; - to validate the ISA-Pack results within industrial packaging production processes, including performance assessment with regards to active and intelligent functionality and impact on food shelf-life, quality and safety; - to undertake a full life cycle and economic assessment of the ISA-Pack products, ensuring clear and quantified results addressing specific priority concerns; Through extension of shelf life the ISA-Pack seeks to reduce retailer supply chain wastage of fresh food produce by 75%.

Keywords: polyhydroxyalkanoate copolymer fermentation reactive extrusion indicator shelf life safety quality freshness structure property relationships cross linking synergistic active grafting integrated time
BioTRANSformation of by-products from fruit and vegetable processing industry into valuable BIOproducts (TRANSBIO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Spain,Germany,Spain,Costa Rica,Portugal,Portugal,Mexico,Germany,Romania,Belgium,Belgium,Spain,Italy,Argentina,Spain
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 4026840.0
EU funding (EUR): 2989465.0
Participants: 16
Project status: CLOSED

The main aim of TRANSBIO is the implementation of an innovative cascading concept for the valorisation of sub-products from fruit and vegetable processing industry using environmental friendly biotechnological solutions like fermentation and enzyme-conversion strategies to obtain valuable bioproducts like plastics (PHB), nutraceuticals / platform chemical succinic acid and enzymes for detergent applications. TRANSBIO will characterize and select appropriate by-products from fruit and vegetable processing industry, followed by adapted pre-treatment and enzymatic hydrolysis procedures to obtain fermentable sugars for microbial fermentation. In order to obtain a broad application potential for the by-products selected, the project will investigate three different fermentation strategies – submerged cultivation (SmF) in liquid media (bacteria, yeasts) and solid state fermentation (SSF) (fungi). Beside optimisation and up-scaling of fermentation Protocols, down-stream processing will be developed keeping in mind economical feasibility, sustainability as well as end-product formation (intracellular, extra cellular). The procedures will be optimised for extra cellular succinic acid production in SmF using novel non-conventional yeast strains and extracelluar enzyme formation in SSF under utilisation of fungi as well as intracellular PHB formation in SmF with bacteria. The obtained PHB will be tested for their packaging application, enzymes will be proved for detergent utilisation and succinic acid will be purified for food application. Beside, original and pre-treated by-products as well as remaining biomass from fermentation strategies will be tested for their potential to be used as feedstock for biogas production via anaerobic digestion.

Keywords: fruit & vegetable by-products,phb,succinic acid,enzymes,smf,ssf