Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using electromechanical stimulations on bone remodeling to speed-up repair bone damage (BONEREPAIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2574732.0
EU funding (EUR): 2574732.0
Participants: 2
Project status: SIGNED

Osteoporosis is a major concern in Europe, resulting in 4.3 million fragility fractures and health care costs in excess of €56 billion annually. Bone, a smart material, can detect microcracks or microdamages and to repair these microdefects due to its growth and remodeling capabilities in the presence of electro-mechanical stimuli. Dry and wet bone involve matrix piezoelectricity, namely a coupling between deformation and polarization. Flexoelectricity, the phenomenon coupling deformation gradients and polarization, still presents experimental and theoretical challenges. Bone biomechanics has been resistant to progress due to the complexity of the propagation of information across the scales of the bone hierarchical microstructure and the multidisciplinary nature of bone biomechanics. BONEREPAIR has the potential to provide a global vision of the effects of electro-mechanical signals on bone remodeling and healing, from the cellular to tissue level, by: 1) Characterizing the response of bone to electro-mechanical stimuli, from cellular to tissue level, via dedicated experiments on biomaterials and bone explants based on novel Bone-on-Chip systems, 2) Modelling the bone cells' response to electro-mechanical stimuli and their gradients, and incorporate them into a unified field theory of bone remodeling and healing, and 3) Designing adequate electro-mechanical stimuli promoting bone healing more efficiently. We hypothesize it is possible to heal bone by applying well-calibrated electro-mechanical stimuli, from the cellular level up to the tissue level, by using multiscale methods to upscale electro-chemo-mechanical phenomena – including piezoelectricity, flexoelectricity, and damage – from microcrack scale up to the tissue level. BONEREPAIR will moreover largely contribute to the development of novel homogenization methods towards generalized continua for composite materials showing multiphysical behavior like piezoelectricity and flexoelectricity.

Keywords: bone remodeling electrical stimulation piezoelectricity flexoelectricity bone healibg damage repair multiscale models multiphysical models measurements bone on chip
Synergistic Catalysis with Advanced Metal-Organic Structures for Sustainable Biomass Conversion (SYMBIOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 2
Project status: SIGNED

Our continued energy reliance on the depleting, and with a large climate footprint, fossil fuel reserves, as well as the increasing instability of the global supply chain network, threaten our energy security, one of the pillars of life-quality, societal, and economic growth. In 2016, 195 countries committed to the Paris Agreement to move towards climate-resilient development with lower greenhouse gas emissions for sustainable growth. The SYMBIOS project offers an innovative green solution by efficiently converting waste biomass into biofuels, promoting our transition toward renewable energy, circular carbon economy, energy security, and reduced environmental footprint. SYMBIOS proposes a ‘symbiotic’ approach between nanoparticulate catalysts and the catalytically active metal nodes of metal-organic frameworks (MOFs), to engineer synergistic and high-efficiency active sites for converting low-energy-density biomass-derived alcohols into higher-energy-density biofuels. Moreover, MOFs crystallization will rely on the synthesis of tailored and functional organometallic building blocks which will stabilize the entrapped nanocatalysts, for their seamless integration. The new catalysts will leverage the unique properties of MOFs to lower energy input reaction requirements and maximize yield, selectivity, and recyclability. SYMBIOS aims to contribute towards the EU’s climate commitments by opening a new avenue for sustainable waste reforming and reducing the reliance on fossil fuels.

Keywords: single atom catalysis waste reforming biofuels metal organic frameworks organometallics nanoparticles
Hybrid ElectriC regional Aircraft distribution TEchnologies (HECATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Ireland,France,Italy,Spain,Germany,Netherlands,Denmark,Poland,Portugal,Austria,United Kingdom
Call: Electrical Distribution Solutions for Hybrid-electric Regional Aircraft (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2026-02-28
Duration (months): 38.0
Total project cost (EUR): 45061246.59
EU funding (EUR): 34142633.59
Participants: 40
Project status: SIGNED

Aviation needs to meet the ambitious targets of the European Green Deal. This means a step change is needed towards hybrid electric regional aircraft to significantly reduce the fuel burn. This can only be accomplished with power distribution networks that can safely handle the high power and high voltage levels, ultimately up to several Megawatt. The HECATE project will address the associated challenges of system weight and power density, high voltage challenges with lightning, arcing and electromagnetic interference as well as optimized thermal management, in addition to digitizing the design process with digital twins. This will lead to transformative technology bricks, which are holistically optimized at system integration architecture level. The HECATE project will demonstrate a >500 kW architecture in a copper bird at TRL5. This will provide a clearer understanding of high voltage challenges and how to mitigate them, with a scalability roadmap towards CAJU Phase 2 flight demonstration and exploitation in a 2035 new built Hybrid Electric Regional aircraft. Also, environmental impact and LCA will be assessed. For optimal alignment and ensuring certifiability, HECATE will establish relationships with other Clean Aviation projects (e.g. HER-01 for MW propulsion, HER-02 for thermal, TRA-01 for architecture, TRA-02 for certification) and authorities and standards groups (e.g. EASA, EUROCAE). As a set of key enabling technologies that are well integrated, HECATE will contribute to the Clean Aviation SRIA and its expected impacts, and fully fulfill the call's expected outcomes. The 37-member consortium mobilizes key EU based industries throughout the entire existing supply chain: from aircraft OEMs to system integrators, to system and subsystems suppliers, 5 of which are SMEs. 17 RTOs, complement and reinforce the industries, which also ensures knowledge gained is embedded in future research and education programs.

Keywords: hybrid electric regional aircraft,electric distribution technologies,high voltage,pohybrid,electric,regional aircraft,distribution technologies,high voltage,digital twin,life cycle assessment
Zero waste Heat vessel towards relevant ENergy savings also thanks to IT technologies (ZHENIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Italy,United Kingdom,Greece,Norway,Spain,Germany,Netherlands
Call: Innovative on-board energy saving solutions (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-06-01
End date: 2026-04-30
Duration (months): 47.0
Total project cost (EUR): 4421226.51
EU funding (EUR): 4384488.25
Participants: 17
Project status: SIGNED

ZHENIT overall objective is to promote Waste Heat Recovery (WHR) as key and “ready-to-implement” solutions to achieve 2030 IMO/EU targets for shipping sector decarbonization. ZHENIT goal is to fully untap “on-board WH potential” developing and validating WHR solutions at different temperature levels towards the exploitation of WH for different on-board services (cooling, power, desalination) thus able to valorise heat in different vessel processes like: WH-to-Trigeneration via an innovative recuperated ORC integrated with an heat pumpt with ejector (T>100°C – NTUA); WH-to-Cooling and Desalination via an adsorption system (70<T<100°C – SORPTION/ITAE); WH-to-Mechanical Work (e.g. for fuel compression) via an isobaric expansion (IE) engine (T<100°C – TECNALIA/ENT). A validation campaign (TRL5) will showcase how WH-to-X if properly integrated with Digital Solutions (energy monitoring and optimized management – SIGLA, KYMA) and wind hybrid propulsion (wingsail by BOUND4BLUE) can bring to a 25% reduction of vessel energy consumption. Validation results will drive a replication roadmap (at regulatory and economic level) towards 2027-2030 marketability of ZHENIT solutions also thanks to realization of replication feasibility studies via modelling tools and approaches already exploited for terrestrial application. The ambitious goal is to integrate all WH-to-X solutions towards a zero WH vessel. The project is driven by a consortium of 13 partners from 6 countries composed by innovative SMEs and excellent R&D Centres (expert in both WHR systems and sustainable shipping) and coordinated by an innovation oriented engineering company (RINA-C), one of the most important EU naval classification body with a deep expertise in sustainable shipping and with a track record of multi-disciplinary EU R&D project Management. The project will be promoted at EU level at policy/Regulation making level also interacting with key platforms like ZEWT, IMO... thanks to RINA-S support too.

Keywords: waste heat,hybrid propulsion,wind,wingsail,ict,energy monitoring,energy management
Cluster for innovative energy (CLUSTER-INN) (CLUSTER-INN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Lithuania,Italy,Poland,Morocco
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 938400.0
EU funding (EUR): 938400.0
Participants: 5
Project status: SIGNED

Energy generation and use obtained new urgency the last year when Russia invaded Ukraine. European and other countries encountered harsh realities when problems related to energy availability and affordability had to be tackled. An urgent need for faster and more efficient transitioning towards renewable sources is evident. The project proposal lies within priority research and innovation. It intends to bring together the scientists and practitioners and involve experienced researchers and early-stage researchers in social sciences, electrical engineering, physics and environmental sciences. Scientists will interact with managers of large-scale solar park clusters in Egypt and Morocco, which would allow understanding specifics and scale of problems related to renewable energy production, use and trade. An interdisciplinary/multidisciplinary approach here may lead to novel solutions, which may have important policy implications. We intend to build a cluster for innovative energy, which will involve other clusters already created in the former Horizon 2020 and other projects. The cluster for innovative energy would be a cluster of clusters allowing broad engagement of scientists, practitioners, policymakers, NGOs and other stakeholders. In the context of the war, innovative solutions stemming from the inter-sectoral cooperation of geographically remoted partners can become resilience drivers. The project is based on previous work but goes beyond since it generates and strengthens long-term collaborations via training researchers, encouraging geographical mobility, and fostering exchange between sectors and disciplines.

Keywords: energy security,solar energy parks,behavioral change,values,renewables
Diagnostic tool that integrates optical, infrared and SAR data - DINOSAR (DINOSAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Colombia,France
Call: Designing space-based downstream applications with international partners (HORIZON-EUSPA-2022-SPACE, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1498481.25
EU funding (EUR): 1498481.25
Participants: 6
Project status: SIGNED

DINOSAR aims to develop Copernicus based algorithms to support smart farming applications that can be used worldwide, clouds, or no clouds. At the moment, most EO based crop monitoring tools are based on optical satellite inputs. In areas with substantial cloud cover the use of these applications is extremely limited. To be able to introduce more sustainable crop management practices, reliable and continuous time series on crop phenology and health throughout the growing season are needed. This will support farmers to match agricultural inputs (fertilisers, pesticides, water) with what the crop actually needs, decreasing their environmental footprint. DINOSAR will do this by integrating the diagnostic power of optical, infrared and Synthetic Aperture Radar (SAR) signals. With the DINOSAR project we intend to kickstart a revolution in EO-based solutions that tackle challenges in agriculture (under clouds) by making full use of the Copernicus infrastructure. We intend to take the existing methodology a step further by designing a multi-sensor operational monitoring method for a single crop (sugarcane) capable of operating on large data volumes, and then extrapolating this approach to practical field cases and to other crops (and geographies) for which the application of EO-based applications has been underexplored. Rather than looking at optical and SAR based data as two parallel signals, we will focus on integrating the two early on in the processing chain. This has not been done before. Sugarcane in Colombia is our initial test-case, but we will not stop there. DINOSAR will also develop a methodology integrating the combined observations from optical, infrared and SAR EO satellites to monitor other crops in other geographies.

Keywords: integration of optical and sar data,crop montoring,colombia
From Bildung to Learning Society. Philosophical Foundations and Mutations of a Modern Ideal (BildungLearning)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1987500.0
EU funding (EUR): 1987500.0
Participants: 2
Project status: SIGNED

The main objective of this project is to compare the modern philosophy of Bildung and the contemporary paradigm of the Learning Society (LS) by systematically analyzing their homological structures. Through this comparison, we aim to expose the important conceptual mutations of the ideal of educational autonomy occurring from the first paradigm to the latter. This research combines history of philosophy and political philosophy and will follow a plan in four steps: 1. Historical reconstruction of the constellation of texts formed around the concept of Bildung in classical German philosophy, through an original typology of the contrasting positions of the main authors of this period, from Herder to Humboldt. 2. Identification and analysis of the most significant critical transformations of the Bildung concept by influential philosophers since the second half the 19th century. 3. Establishment of a corpus of scientific and political texts and discourses on the LS, for comparing the paradigm of LS to the modern philosophy of Bildung following an analytical grid pointing the conceptual and normative homologies and mutations between them. 4. Concrete application of this systematic comparison and testing of the heuristic potential of the Bildung philosophy in the particular context of the current debates on the transformations of the Idea of University. The novel aspects of the this project are twofold: (a) To provide an innovative comparative method for systematically analyzing the contemporary mutations of modern philosophical concepts. (b) To lay the foundations for a comprehensive philosophy of University and academic freedom. Through an analysis of political-educational narratives, we will show that the great narratives of the philosophical modernity – such as emancipation through self-cultivation – have not become obsolete or ineffective, but continue to be operating in current discourses under critical and fragmented forms.

Keywords: modern philosophy german idealism philosophy of culture idea of university
Innovative methodologies for the design of Zero-Emission and cost-effective Buildings enhanced by Artificial Intelligence (ZEBAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Belgium,Netherlands,United Kingdom,France,Ukraine,Greece,Germany
Call: Innovative cost-efficient solutions for zero-emission buildings (HORIZON-CL5-2023-D4-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 4355763.85
EU funding (EUR): 3879168.25
Participants: 18
Project status: SIGNED

ZEBAI is an ambitious integrative project in which a broad range of interdisciplinary teams collaborate to develop a new methodology that aims to change the way that Zero-emission buildings are designed, by integrating all interdependent analysis and partial alternative decision-making processes under a holistic approach that allows the evaluation of a design simultaneously taking into account: energy performance, environmental impact, indoor environmental quality, and cost-effectiveness. For this purpose, we will require to develop a database of well-characterised materials and make an estimation of discrepancies between simulated and actual building performance. The methodology that will be used is artificial intelligence techniques to optimise the selection of materials and systems in different aspects of the building design. The AI-assisted methodology aims to make the design process more efficient and user-friendly while incorporating all environmental quality and cost-effectiveness objectives. This approach will enable the optimisation of new architectural designs towards scalable Zero Energy Building (ZEB) design in different climates, usages, and building patterns, with the ultimate goal of achieving a zero-emission building stock by 2050. During the project, we will test ZEBAI methodology with four representative demonstrators (located in Ukraine, Spain, the United Kingdom, and the Netherlands). ZEBAI relies on previously funded European research projects and aligns with several national initiatives in which the partners collaborate.

Keywords: artificial intelligence,material characterisation,zero emission buildings,digital green technologies,climate neutral building stock,hvac systems,renewable energy,well being,circular economy
Exposing hidden targets of drug resistance in cancer by mapping the epitranscriptome at single-cell resolution (EpiResist)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1496578.75
EU funding (EUR): 1496578.75
Participants: 1
Project status: SIGNED

Drug resistance is one of the biggest challenges in the clinical management of breast cancer (BC), but the underlying mechanisms are still not fully understood. What we do know is that epigenetic mechanisms play a key role in the adaptation of cancer cells to therapy, which is why they have become a prime field of investigation. Single-cell profiling of epigenetic DNA and histone modifications have already revealed intriguing and actionable insights into tumor heterogeneity. For the most recently discovered epigenetic layer however, which consists of RNA modifications, we have not yet reached single-cell resolution. The exciting potential of RNA modifications to fine-tune the processing and expression of mRNAs is currently an area of intense research termed ‘Epitranscriptomics’ and the most prevalent and best studied of these mRNA modifications, N6-methyladenosine (m6A), has recently been linked to drug resistance in cancer. Our lab has uncovered a new m6A-based layer of dysregulation of a major cancer pathway driving therapy resistance in BC. The ability to study m6A in single cells holds great promise as it would enable us to further delineate tumor heterogeneity and to find novel drug resistance targets that have eluded us so far. I propose to develop a method for streamlined m6A mapping at single-cell resolution (Aim 1), to apply it to triple-negative BC (TNBC) cells driven to chemoresistance in cell culture, mice, and human samples so as to determine uncharted targets of drug resistance (Aim 2), and to disrupt m6A-regulated chemoresistance targets in order to prevent therapy failure (Aim 3). These aims are aligned with my knowledge and skills related to both m6A and drug resistance. This unique and comprehensive analysis of the single-cell m6A methylome will provide invaluable new insights into the unknown epigenetic characteristics of chemoresistance and will pave the way for new therapeutic interventions.

Keywords: epigenomics,epitranscriptomics,rna epigenetics,m6a,mrna,breast cancer,chemotherapy,anthracyclines,tumor evolution,tumor heterogeneity,cancer therapy resistance,drug resistance