Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human Pluripotent Stem Cells: the new heart patient? (STEMCARDIOVASC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Netherlands
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-11-01
End date: 2018-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The ability to generate pluripotent stem cells (iPSC) by reprogramming somatic tissues is arguably the greatest breakthrough in biomedical science of the last decade. The most inaccessible cells of the body can now be derived repeatedly from any individual. This could have a huge impact on understanding disease and the development of new therapeutic drugs but it will require a new level of sophistication in bioassays to create disease models and monitor disease phenotypes. The project I propose here will take up this challenge for the cardiovascular system, creating new human models of heart failure and vascular disease that presently do not exist. My group is uniquely positioned in Europe to realize these ambitions through more than a decade of research on cardiac and vascular cells from human embryonic stem cells and more recently hiPSC; its present location in Leiden University Medical Centre is optimal for fostering clinical links. My group is one of few worldwide that uses conventional homologous recombination in human PSCs. My aims here are (1) develop protocols for differentiating all cells of the heart (2) engineer synthetic and native human myocardium that models healthy tissue and common disease states and (3) generate sets of isogenic diseased hPSC to model pathogenesis. This will be realized by deriving lineage marked “rainbow coloured” reporter hPSC lines, introducing selected (immature) cardiovascular cells into engineered constructs and subjecting them to mechanical/biochemical stress factors like cyclic contraction and fluid flow that would normally induce maturation and disease. The constructs will support simultaneous measurement of functional tissue parameters and include hiPSC from relevant diseases, genetically or pharmacologically rescued and isogenic hESC with the corresponding gene mutations. These new “sick human heart” and “ diseased vessel” models and novel bioassays will significantly advance technology to have major impact on the field.

Keywords: pluripotent stem cells,cardiovasacular disease,disease models,cardiomyocytes,tissue enigineering
The causes of hyperglycaemia in the face of rising obesity (GLUCOSEGENES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: United Kingdom
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-10-01
End date: 2018-09-30
Duration (months): 60.0
Total project cost (EUR): 2007925.0
EU funding (EUR): 2007925.0
Participants: 1
Project status: CLOSED

The aim of this proposal is to make a major advance in understanding why some people develop diabetes despite relative leanness and why others maintain normal glucose levels despite obesity. My vision is that human genetics and the ability to study humans will provide a major leap in understanding disease mechanisms. We will use state of the art resources in genomics, metabolomics, and large human biobanks to study three stages in life that may influence predisposition to diabetes independently of obesity: in utero life: We will test the hypothesis that the in utero environment alters offspring glucose levels and metabolism. We will perform the most comprehensive analyses of the in utero environment using mass-spectrometry based metabolomics. We will use maternal genetic factors that influence glucose levels in pregnancy to test the causal effects of the in utero environment on offspring outcomes. “long-term” life: We will test the hypothesis that long-term exposure to altered metabolic and circulating factors influences glycaemia and metabolism. We will use the principle of Mendelian randomization to identify the subset of known and novel biomarkers that are likely to play a causal role in diabetes disease processes. “Pre-diabetes” life: We will test the hypothesis that non-diabetic individuals carrying different type 2 diabetes genetic risk factors will have different physiological characteristics. Little is known about the detailed physiology of individuals carrying the greatest number of genetic risk factors. We will perform detailed physiological studies in non-diabetic individuals predisposed to type 2 diabetes based on specific genetic risk factors. These characteristics may inform intervention and treatment strategies targeted at those at greatest genetic risk of diabetes.
Secretariat of the Implementing Geological Disposal of Radioactive Waste - Technology Platform - Phase 2 (SECIGD2)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Destination: Management of Ultimate Radioactive Waste
Action type: Coordination and support actions
Countries involved: France,United Kingdom,Finland,Belgium
Call:  (FP7-Fission-2012, 2012)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 1424629.2
EU funding (EUR): 790000.0
Participants: 4
Project status: CLOSED

The Implementing Geological Disposal of Radioactive Waste – Technology Platform (IGD-TP) was established in 2009. This project through a Secretariat, aims at further deepening integration and coordination of the activities of the IGD-TP participants. This project includes activities involving all committed participants (80) and beyond all interested entities through Exchange Forums. The proposed Work Packages have been set up in order to: • Provide an efficient management of the IGD-TP and its operation so that the mission and objectives are achieved and the benefits from the work are widely spread, • Network, structure and develop Research, Development and (RD&D) programmes and competences in countries with less advanced geological disposal programmes. Public events will be organized to foster the RD&D activities in countries with less advanced programmes are proposed, • Contribute to fulfilling the requirements, including advice and expertise, laid down in the new EU Directive on the management of radioactive waste, and • Develop, implement and coordinate education and training activities in geological disposal in Europe within the Terms of Reference set for the IGD-TP's Competence Maintenance, Education and Training Working Group. For the period 2013-2015 the main objective of the IGD-TP is to deploy the Joint Activities identified in the Deployment Plan (DP) with the support of the Secretariat according to the timeframes set in the Vision Document, the Strategic Research Agenda 2011 (SRA) and in the Deployment Plan (DP). IGD-TP and its Secretariat do have a programmatic role which goes far beyond FP7 projects and encompasses the coordination of RD&D activities related to geological disposal from 11 Member States (and Switzerland). The Secretariat will promote the scientific and technical quality of the Research, Development and Demonstration (RD&D) by fostering interactions between national programmes. In this dissemination function, it maintains a website where e.g. progress reports and announcements for future events are published.

Keywords: secretariat,technology platform,geological disposal,radioactive waste
Face Recognition: Understanding the role of within-person variability (FACEVAR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The Human Mind and its complexity
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2012-ADG_20120411, 2012)
Start date: 2013-06-01
End date: 2018-05-31
Duration (months): 60.0
Total project cost (EUR): 1496263.0
EU funding (EUR): 1496263.0
Participants: 2
Project status: CLOSED

This project represents a new way to look at the problem of human face recognition. Despite a large amount of research on this topic, we still do not understand the most fundamental aspect of face processing: how can we identify the people we see? This is a key problem in human perception, but it also has practical implications in forensic and security settings. This project has its roots in a simple observation: pictures of the same face can look very different indeed. In the standard approach to face recognition, this commonplace fact is treated as an inconvenience. Differences between pictures of the same person are regarded as ‘noise’, and either ignored, or eliminated by systematically controlling the images used for research. This research programme takes exactly the converse approach. Instead of trying to control away this variability, we wish to study it explicitly. Under this approach, the focus is not how to ‘tell people apart’, but instead how to ‘tell people together’ – how to bring together superficially different images into a coherent representation. Early work suggests that a very important component of familiar face recognition is the ability to generalize over superficial image differences – differences which tend to fool unfamiliar viewers, as well as automatic computer-based systems. The current failure to address this variability may account for the slow progress in face identification – progress which has fallen behind the understanding of other aspects of face processing such as social perception. By studying this missing component of face recognition, a novel theoretical model will be developed which has the potential to make a significant contribution.

Keywords: face perception
Full Scale Demonstration of Plugs and Seals (DOPAS)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Destination: Management of Ultimate Radioactive Waste
Action type: Collaborative project
Countries involved: Finland,France,Germany,Germany,Switzerland,United Kingdom,Czechia,Sweden,Netherlands,United Kingdom,Finland,Czechia
Call:  (FP7-Fission-2012, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 15744518.3
EU funding (EUR): 8700000.0
Participants: 16
Project status: CLOSED

DOPAS aims to improve the adequacy and consistency regarding industrial feasibility of plugs and seals, the measurement of their characteristics, the control of their behavior over time in repository conditions and also their hydraulic performance acceptable with respect to the safety objectives. This DOPAS project addresses the design basis, reference designs and strategies to demonstrate the compliance of the reference designs to the design basis, for plugs and seals in geological disposal facilities. The project focuses on shaft seals for salt rock (German repository concept), tunnel plugs for clay rock (French and Swiss repository concepts), and tunnel plugs for crystalline rock (Czech, Finnish and Swedish repository concepts). Five different demonstration experiments are part of the project and will take place in Sweden, France, Finland, Czech Republic and Germany. They are in different state-of-development. The Swedish demonstrator will be constructed prior to start of the DOPAS project and will basically provide experience on demonstration of compliance of reference design to the design basis. German demonstrator will be installed after the DOPAS project and will focus on demonstration of suitability by performance assessment. The French, Finnish, Swedish,German and the Czech experiments will address developments in all phases of design basis, reference designs and strategies to demonstrate compliance of reference designs to design basis. The studied concepts will be developed in the DOPAS's five thematic scientific/technological work packages, which each integrate the results of the individual experiments. The DOPAS project is derived from the IGD-TP's Strategic Research Agenda that points out the topic of “plug and seals” as a first priority issue for joint European RTD projects.

Keywords: geological disposal,ultimate radioactive waste management,repository components,repository plugs,repository seals
Safety of ACtinide Separation proceSSes (SACSESS)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Collaborative project
Countries involved: France,Sweden,Spain,Czechia,Italy,Poland,Czechia,France,European organisations area,Germany,Germany,United Kingdom,Switzerland,Netherlands,France,United Kingdom,United Kingdom,United Kingdom,Japan
Call:  (FP7-Fission-2012, 2012)
Start date: 2013-03-01
End date: 2016-06-30
Duration (months): 40.0
Total project cost (EUR): 10266535.1
EU funding (EUR): 5550000.0
Participants: 26
Project status: CLOSED

Nuclear power plays a key role in limiting EU’s greenhouse gases emissions, and makes an important contribution to improve European Union’s independence, security and diversity of energy supply. However, its social acceptance is closely linked to an enhanced safety in the management of long-lived radioactive waste contributing to resource efficiency and cost-effectiveness of this energy and ensuring a robust and socially acceptable system of protection of man and environment. Among the different strategies, partitioning and transmutation (P&T) allows a reduction of the amount, the radiotoxicity and the thermal power of these wastes, leading to an optimal use of geological repository sites. In line with the Strategic Research Agenda of SNE-TP, the SACSESS collaborative project will provide a structured framework to enhance the fuel cycle safety associated to P&T. In addition, safety studies will be performed for each selected process to identify weak points to be studied further. These data will be integrated to optimise flowsheets and process operation conditions. A training and education programme will be implemented in close collaboration with other European initiatives, addressing safety issues of nuclear energy industry. The multidisciplinary consortium composed of European universities, nuclear research bodies, TSOs and industrial stakeholders will generate fundamental safety improvements on the future design of an Advanced Processing Unit. SACSESS will thus be an essential contribution to the demonstration of the potential benefits of actinide partitioning to the global safety of the long-lived waste management.

Keywords: safety,aqueous separation processes,pyrochemical separation processes,chemistry,fukushima,corium management
Methodology, Analysis and eXperiments for the "Safety In MYRRHA Assessment" (MAXSIMA)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Collaborative project
Countries involved: Belgium,Italy,Germany,Italy,Germany,Netherlands,Italy,Sweden,Germany,Romania,Sweden,Spain,Kazakhstan
Call:  (FP7-Fission-2012, 2012)
Start date: 2012-11-01
End date: 2018-10-31
Duration (months): 72.0
Total project cost (EUR): 10087542.0
EU funding (EUR): 5500000.0
Participants: 14
Project status: CLOSED

The Strategic Research Agenda of the EU Sustainable Nuclear Energy Technical platform requires new large infrastructures for its successful deployment. MYRRHA has been identified as a long term supporting research facility for all ESNII systems and as such put in the high-priority list of ESFRI. The goal of MAXSIMA is to contribute to the "safety in MYRRHA" assessment. MAXSIMA has five technical work-packages. The first contains safety analyses to support licensing of MYRRHA. Design-based, design extended and severe accident events will be studied with a focus on transients potentially leading to fuel pin failures. Fuel assembly blockage and control system failure are the least unlikely events leading to core damage. For code validation a thermal-hydraulic study of different blockage scenarios of the fuel bundle and tests of the hydrodynamic behaviour of a new buoyancy driven control/safety system are planned. Both are supported by numerical simulations. Safety of the Steam Generator is treated by looking at consequences and damage propagation of a SG Tube Rupture event (SGTR) and by characterising leak rates and bubble sizes from typical cracks in a SGTR. Additionally a leak detection system and the drag on bubbles travelling through liquid LBE are studied. MOX fuel segment qualification with transient irradiations is a big step in licensing. MAXIMA include validation experiments for safety computer codes involving core damage scenarios with high temperature MOX-LBE interactions. Fuel-coolant-clad chemistry is studied up to 1700°C and a core melt experiment in a reactor is prepared to assess the interaction of LBE with molten fuel. Following the Fukushima accident, effort is put on development of enhanced passive safety systems for decay heat removal and on confinement analyses for HLM systems. A separate work package is dedicated to education and training. Beside workshops, lecture series and training sessions, virtual-safety simulator software will be developed.

Keywords: myrrha,esnii,snetp,safety analysis,safety by design
DESIGN AND MANUFACTURING OF AN INNOVATIVE CRYOGENIC WIND TUNNEL MODEL WITH MOTORIZED EMPENNAGE (IDAMME2)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: France
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2013-01-02
End date: 2015-08-01
Duration (months): 31.0
Total project cost (EUR): 1795000.0
EU funding (EUR): 1346250.0
Participants: 1
Project status: CLOSED

Since 40 years, our company “VALLET- CMA” showed our capacity to build models by taking into account the specific requirements of this type of activity. We always research innovation and appropriate technologies in our design. The standard design tool used at VALLET- CMA is CATIA V5 (Rev: 19 as required), utilizing the associated FEA package for all stress calculations. The manufacture of models for a “Cryogenic Wind Tunnel” requires higher surface quality requirements. We have a knowhow to obtain this surface quality required. (We manufactured similar models for the ETW wind tunnel) We will make best use of state of the art rapid manufacturing processes where appropriate, including the various additive layer manufacturing processes (laser deposition). These techniques present the opportunity to reduce model costs and lead times, with the added advantage of lower raw material usage and the associated reductions in energy usage and waste. VALLET - CMA actively work with partners outside of this CfP to develop model manufacturing techniques using these novel processes. Our priorities are: - The respect of surface quality requirements with different technologies (High speed cutting, electric discharge machining, chemical cutting, …) - An innovate design of the various leading edge components to be dependable, quick and faithful - Using innovative technologies (long drill EDM) for the integration of the standard pressure sensors without perturbations of external forms. In the particular context of this project, the implementation of a large number of pressure probes should not disturb the surface quality. To this end, we can combine multiple technologies in innovative ways: Drilling deep-EDM allows small diameter (1mm) to great depths with a very high quality of rectitude. This will come as close as the thin zones (trailing edge) to create paths for the transfer of internal pressure information. (Cables, tubes)

Keywords: cryogenic model,motorized empenage,laminar flow,pressure probes,kulites,brake,mirror polishing,removable trailing edge,instrumented,winglet,karman,innovative,software management
Development of a rapid, multifunction, automated gap filler device (NOGAP)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2013-06-01
End date: 2014-06-30
Duration (months): 13.0
Total project cost (EUR): 546786.4
EU funding (EUR): 286256.2
Participants: 2
Project status: CLOSED

Natural Laminar Flow (NLF) has been identified as a key technology to contribute to the reduction of emissions in aircraft transport. However, the stringent NLF surface requirements are difficult to be reached with conventional manufacturing processes. The aim of NOGAP project is to develop a fully automated gap filler device that is able to performance in a 3D environment and achieve surface finish within NLF tolerances at high production rates. To achieve its purpose, NOGAP project will integrate different systems in a single multifunction robot: • Computer Vision device and 2D laser measurement device integrated in a verification system, for guidance, surface scanning and post-application metrology control • Innovative filler injection system with flow software control and variable-geometry nozzles (under patent development) • Multiple operation for accelerated curing (thermal, UV) and/or secondary finishing The flexibility and automation of assembly tooling is therefore a step forward to achieve the Aeronautical Factory of the Future based on the concept of “Smart Factory”.

Keywords: filler,sealant,natural laminar flow,automation,joint,surface finish,aircraft assembly line,mnufacturing techniques.