Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting Confocal Microscopes by Quantum Image Scanning Microscopy (QUISM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The goal of the QuISM project is to develop an add-on module for confocal microscopes which will enhance the spatial resolution of the microscope by up to a factor of 4 and provide quantitative fluorescence imaging, taking advantage of the Quantum-assisted Image Scanning Confocal method recently developed within the frame of the ColloQuantO ERC-CoG project. Image-scanning confocal microscopes (ISM), proposed several decades ago and demonstrated for the first time in 2010 are already a commercial reality (led by the Zeiss "Airyscan" system). Our recently developed method takes advantage of the inherent quantum properties of fluorescence emission to achieve an up to a 2-fold improvement of resolution in ISM without compromising any of the advantageous properties of the standard ISM system. The only significant hardware changes required for QuISM are the operation of the detector in single-photon counting (“Geiger”) mode and the addition of an electronic correlator element which performs preliminary data analysis on the readout of the stream of photons from the detector array. Within this configuration, “standard” ISM data is readily obtained even when a microscope is operated in QuISM mode. The QuISM project will set the basis for commercializing QuISM by substantiating the already commercialized CMOScompatible single photon avalanche photodiode array detectors are suitable for this method, proving that the method is applicable for conventional fluorophores used in biology experiments, as well as by developing proper image analysis tools which can fully exploit the potantial of QuISM in terms of acquisition time and quantitative assessment of samples.

Keywords: confocal microscopy,superresolution,organic dyes,antibunching,quantitative fluorescence,microscopy
Liquid-Processed Solid-State Li-metal Battery: development of upscale materials, processes and architectures (SOLiDIFY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Germany,Switzerland,Belgium,Belgium,Belgium,Latvia,France,Netherlands,Netherlands
Call: Strongly improved, highly performant and safe all solid state batteries for electric vehicles (RIA) (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 7823927.5
EU funding (EUR): 7823927.5
Participants: 14
Project status: SIGNED

The SOLiDIFY project proposes a unique manufacturing process and solid-electrolyte material to fabricate Lithium-metal solid-state batteries – known as Gen. 4b on the EU battery roadmap. The concept is based on a solid nanocomposite electrolyte or nano-SCE. It is made by a sol-gel reaction which is used advantageously for a liquid-to-solid approach in the fabrication of the composite cathode and the solid-electrolyte separator. The general strategy to reach the target energy density of 1200Wh/L (400Wh/kg) in 20 minutes charging time is: (1) enabling the integration of high-energy NMC active materials and (2) development of new electrode architectures for high mass loading and enabled by the liquid-to-solid approach. An added imposed challenge is a water-based cell assembly process. To this end, suitable protection of the high-energy NMC powder with ALD thin-film coatings is pursued. Finally, thin lithium foils with protective artificial interphase coatings will be developed for lamination on the nano-SCE separator. The main goal of SOLiDIFY is to bring the liquid-processed solid-state cell fabrication concept from demonstration in the lab (TRL3) to demonstration of prototypes in pilot line (TRL6), with upscaling of the concept both towards (1) the development of manufacturable materials and processes and (2) the discovery of full cell assembly schemes with ultimate demonstration of 1Ah pouch cells. The material research will focus on (1) solutions enabling the upscaling process and manufacturability and (2) further improvement of cell integration steps to enhance performance. Manufacturable parameters such cost, environmental impact and recycling will also be handled. The larger scope of the SOLiDIFY project entails the development of a novel and potentially European-lead solid-state battery technology with fully covered EU value chain.

Keywords: solid composite electrolyte sce,ionic liquid based sce,ionogel,thin lithium foil,artificial interphase,solid state battery,lithium metal solid state battery
Economic Uncertainty and Fertility in Europe (EU-FER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1689272.0
EU funding (EUR): 1689272.0
Participants: 1
Project status: SIGNED

EU-FER is a project about Economic Uncertainty and FERtility in EUrope. Economic uncertainty may be interpreted as an individual risk factor, mainly related to the labour market (e.g. unemployment, short-term contract jobs, underemployment, or a combination of these), but it may also be conceptualized as a macro-level phenomenon, reflecting the general uncertainty felt by people in times of economic turbulence. The recent Great Recession, spanning 2007 to 2009 and featuring downturns in both financial and labour market fortunes, has fuelled interest in understanding whether economic uncertainty, which does not appear to be a transient phenomenon, affects fertility. The economic uncertainty/fertility nexus is far from being clearly understood: theoretical premises are weak and empirical findings send conflicting messages. The goal of this project is to generate new knowledge on if, how, and under what circumstances economic uncertainty matters for fertility in contemporary Europe, adopting a cross-country comparative approach. The use of new data, methodologies, and tools may advance our knowledge on this topic. EU-FER is based on three pillars: a meta-analysis of previous research, a cross-country laboratory experimentation design, and micro-level longitudinal analyses. EU-FER ensures a strong interdisciplinary perspective, with the following overall goals: • to advance the understanding of the causal impact of economic uncertainty on fertility addressing this issue in a comprehensive way and from different perspectives, using various measures of uncertainty, and testing aspects that remain unclear from the current body of research; • to enhance the boundaries of demographic research by illustrating the benefits of a laboratory experimentation design; • to communicate findings and stimulate the academic and policy debate on how economic uncertainty matters for fertility.
Modelling Tree Response to Aridity Increase with Traits (M-TRAIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-06-20
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The changes in precipitation patterns that are projected for the coming decades are expected to increase the frequency and intensity of droughts. Despite the potentially dramatic impacts on wood and forest-based ecosystem services, the effect of these changes in the hydrological cycle on European forests is still highly uncertain. One reason for this gap in the knowledge is the inadequacy of the tools currently used to address large-scale land-atmosphere processes at continental scales, the land surface models (LSMs). Indeed, the predictive power of LSMs is hampered by their heavy parameterization of empirical hydrological modules, with parameters fixed per broad plant type irrespective of the environmental conditions. This representation is contradictory to the ecological processes of acclimation and selection and makes the LSMs unsuitable outside of their calibration range especially under extreme conditions. Ecologists have now made progress in describing traits – tree characteristics that define plant growth strategies. Plant traits vary as much within species as between species, as individuals and communities adapt to their environmental conditions. M-TRAIT will bring the latest ecological findings together with a state-of-the-art LSM to model large-scale forest response to droughts. The trait determinants to the drought response of trees will be determined from analysis of worldwide trait databases. The relationships between traits and with the environment will be formulated. The key traits will then be integrated into a forestry-enhanced LSM with an individuals-sampling approach in which a large number of plant growth strategies are initialized and allowed to interact with environmental conditions. The outcome of M-TRAIT will be 100-year simulations of the drought effect on forests under different climate change scenarios, as well as an analysis of the consequences for forest-based ecosystem services based on proxy ecological variables.

Keywords: forest,drought,model,climate change,europe,traits,eco physiology
Clean Air - Reduce Vehicle Emissions (CARVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2017-11-30
Duration (months): 27.0
Total project cost (EUR): 2709860.0
EU funding (EUR): 1896902.0
Participants: 1
Project status: CLOSED

Challange: Air pollution is a huge problem causing millions of deaths each year and one of the main contributors is NOx emission from diesel vehicles. To counter this the EU Euro Standards were introduced in 1990, designed to limit the harmful emissions. Increasingly strict legislation has been imposed, but existing technologies have not yet been able to meet the set NOx emission limits under real-world driving conditions, and as a consequence there has been no significant impact on NOx emissions. Solution: Amminex’ ASDS technology offers a beyond state-of-the-art solution for reducing NOx emissions under real-world driving conditions, thus enabling diesel vehicles to meet Euro Standards and future tightened standards, while at the same time securing a significant reduction in the fuel consumption. Even though competing solutions are able to meet current Euro Standards in lab tests, they are not able to reduce NOx emissions from exhaust efficiently under real-world driving conditions, which is why the air pollution problem remains unsolved. The unique ASDS solution has the ability to meet Euro Standards in both lab-testing and in real-world driving tests, and consequently make a real contribution to improving air pollution. The project: Amminex has already developed a retrofit system with the ASDS technology, which has been demonstrated on city busses with excellent results. Based on this retrofit product, the objective for this project is to develop and optimise the technology from a retrofit to a first-fit solution for the two segments: passenger cars and light commercial vehicles (vans). The customers: The two most relevant market segments for the further development of the ASDS technology are diesel passenger cars and diesel vans worldwide, for which this project sets out to develop and demonstrate a first-fit prototype ASDS system. With the typical driving pattern of these vehicles, these two segments will benefit highly from the ASDS technology.

Keywords: nox emission reduction,adammine,passenger cars,vans,exhaust,adblue,ammonia storage and dosing system asds
Innovative Strategies towards Halogenated Organic Molecules: From Reaction Design to Application in Drug Synthesis (HALODRUGSYN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1496664.3
EU funding (EUR): 1425986.8
Participants: 2
Project status: CLOSED

Halogenated arenes and heteroarenes have become essential structural motifs of the pharmaceutical industry to create novel drugs against bacterial infections and cancer, and constitute highly valuable functional units in chemistry. Current methods for the installation of carbon-halogen bonds lack efficiency, selectivity, and practicability within the complex molecular setting of drug development processes. These restrictions prevent many potential drugs from being synthesized in a time- and cost-efficient manner. In this project, I aim to address these challenges by engineering a highly elaborated synthetic toolbox that is equipped with novel transformations of unprecedented efficiency, selectivity and practicability. I will apply these transformations to the construction of novel antibiotics against resistant strains and more efficient chemotherapeutics to combat cancer. The first objective is to establish innovative transformations that enable for the first time an efficient access to halogenated arenes. I will accomplish this goal by developing novel ring-expansion reactions and apply them to the first synthesis of the antibiotic salimabromide in order to address the acute problem of antibiotic resistance. Within the second part of this project, I will extend this unique synthetic platform to heteroarenes and establish a groundbreaking method based on carbon-fluorine bond activation. This will represent the first broadly applicable strategy to produce novel fluorinated heteroarene based anti-cancer drugs with unparalleled precision, efficiency and selectivity. Taken together, the realization of these strategies, all of which are unprecedented, provides for the first time a solution for the limitations associated with current methods. With my expertise in synthetic chemistry, which I have gained from my achievements in natural product synthesis, and an outstanding publication record in this research field, I am confident to accomplish these ambitious goals.

Keywords: natural products,total synthesis,halogenated molecules,ring expansion,fluorine chemistry,methodology
Understanding the mechanisms of pain modulation through expectations (conscious and unconscious) in placebo analgesia induced in the context of fear conditioning - MEG and EEG study (NeuroCon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Chronic pain patients cannot be efficiently treated with pharmacological methods and hence investigating alternatives such as psychological-based treatments is essential. One of the well-recognised method of analgesia is placebo which is based on learning processes – classical conditioning (CC). Through CC, expectations about pain relief are formed and those are recognised to mediate the placebo effect. Moreover, the effects of CC play a prominent role in the development of chronic pain-related fear and disability, so investigating the basis of fear conditioning may help developing better pain management strategies. Expectations about pain relief are shown to reduce the activation of pain-related brain regions and cues associated with pain decrease are processed in higher-order areas of the brain. However, the latest studies are inconclusive in determining to what extent expectations are elicited consciously or unconsciously and it is suggested that it depends the way the effect is generated - simple conditioning or conditioning with verbally induced expectations. In order to bring new light on this subject, the neural basis of the process and how the brain activity changes in order to recognise relevant and irrelevant information during conditioning still needs further investigation. In order to understand the relation between CC and expectancy in placebo analgesia, this project will implement both types of CC in the context of basic fear conditioning procedure. The brain activity will be measured using MEG and EEG technique and investigated using multiple methods of signal analysis which is a novelty in placebo research. The aim of the project is investigating how sensory cortices are modified to better detect relevant information using MEG and studying anticipatory brain activity using EEG. It may provide an answer to what extent conscious and unconscious processes are involved in pain modulation and what regions of are involved in this process.

Keywords: placebo,fear conditioning,pain modulation,neuroimaging
reinforcing SustainablE Actions, resilience, cooperation and harmonisation across and by the SEA-EU Alliance (reSEArch-EU)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Spain,Malta,Croatia,Poland,France
Call: Support for the Research and Innovation Dimension of European Universities (Part I) (H2020-IBA-SwafS-Support-1-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1999952.5
EU funding (EUR): 1999952.5
Participants: 6
Project status: SIGNED

To many Europeans, the sea is a bridge and border, resource pool and playground. Coastal regions account for almost half the EU’s gross domestic product; and the Blue Economy beckons, with exciting growth prospects. Coasts suffer from a high dependence on few economic activities (e.g. tourism and shiprepair); they must also somehow manage the many recreational, social and industrial activities that cause unprecedented environmental stress. We have learned from the current pandemic scenario that knowledge is a key investment to combat such fragility and non-sustainability. In this context, the 6 coastal universities of the European University of the Seas (SEA-EU) alliance are pooling their complementary expertise to develop the reSEArch-EU project. Its aim is to bolster the research and innovation capacity of SEA-EU, in step with our shared, integrated and long-term strategy, by: building an anti-fragile (beyond resilient and robust) and innovative pan-European Alliance; aligning our expertise and resources with the needs of the production system; co-designing, co-creating and co-delivering knowledge with and for stakeholders and citizens; establishing a common Open Science and Open Research Data Policy; crafting and developing a common multi/ inter/ and trans/disciplinary research agenda that contributes to sustainable development and growth; sharing our critical analyses and best practices for the successful implementation of our research and innovation strategies with other ‘European University’ Alliances. Herein, we propose to craft a solid, reliable and trustworthy research structure for the SEA-EU Alliance. This will be visible to, and active with, main societal actors (citizens, entrepreneurs, corporate bodies, administrators) in order to grow together, galvanise our institutions, reinvigorate our economic landscapes, and help address societal and environmental challenges locally and beyond.

Keywords: anti fragility,resilience,sustainability,green campus,entrepreneurship,innovation,transdisciplinarity,transformation,co creation,citizen science,open science,research agenda
Common Framework for a European Life Cycle based Asset Management Approach for transport infrastructure networks (AM4INFRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Austria,Germany,Belgium,Greece,Slovenia,Netherlands,Netherlands,United Kingdom
Call: Smart governance, network resilience and streamlined delivery of infrastructure innovation (H2020-MG-2015-Singlestage-B, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 1499860.0
EU funding (EUR): 1499860.0
Participants: 10
Project status: CLOSED

Achieving a well integrated, optimal performing transport infrastructure network in Europe is a key element in the White Paper on Transport’s overall ambition for a single European Transport Area in 2050. As such it complements and supports the pillars on efficient and sustainable transport means and operations. The required integration and enhancement of the European transport infrastructure networks needs a shift towards next levels of governance capabilities that can adequately address the key societal challenges. In the framework of this CSA on a life cycle based asset management approach for transport infrastructure networks, these challenges are related to: An unprecedented call for network capacity and performance An unprecedented call for transparent, coherent and consistent decision making on cost-performance The (mostly public) financing of the transport infrastructure system has met with concrete fiscal limits. Already in many countries in the EU, this has led to a backlog in maintenance and replacement. Unless decisive actions are taken on network construction, maintenance and operations, this trend will result in mounting congestion losses in the economic powerhouses on the short term and to prohibitive obstructions in transport flows across the European transport network on the medium term. This calls for cross asset, cross modal and cross border decision making by the appropriate authorities, implying their close coordination and collaboration. The precondition for this is transparency to each other as well as to policy and society. This requires them to share a common vision and objectives, in a common language and from a common information base. The governance challenge is to provide the key stakeholders in the infrastructure governance with appropriate data, methods and tools in order to enable their decision making on cost-performance to be transparent, coherent and consistent across the assets, across the modes, and across the borders.

Keywords: infrastructure networks,asset management,national infrastructure agencies