Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrogen For All of Europe (HY4ALL) (HY4ALL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Coordination and support actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Spain,Italy,France,France,United Kingdom,United Kingdom
Call: Develop strategies to raise public awareness of fuel cell and hydrogen technologies (H2020-JTI-FCH-2014-1, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 2035349.11
EU funding (EUR): 1998339.3
Participants: 13
Project status: CLOSED

Despite major technological development and the start of commercial deployments of the fuel cells and hydrogen technology, the public awareness of FCH technologies has lagged behind this technical progress so far, restricting the appetite of potential customers and risking a lack of support from policymakers. To address this challenge, a consortium of leading experts has come together, combining communication experts, PR of established manufacturers and technology suppliers and world-class experts on the societal benefits of low carbon technologies. Together, the they will deliver HY4ALL, an ambitious programme to drive a step-change in awareness and excitement around fuel cells and hydrogen and deliver clear and consistent messages that resonate with all audiences, from policymakers to the general public. The project will be active in minimum 11 member states, and will be closely linked to the large numbers of existing hydrogen initiatives and demonstrations, maximising its impact and allowing the communication strategy to influence dissemination work beyond the project for lasting effects. The project aims will be delivered through the following activities: • Development of an overarching communication strategy, that will form the basis for all subsequent project activities and will allow the FCH community to speak with ‘one voice’ • Creation of an interactive web portal for FCH technologies, providing a ‘one stop shop’ for visitors seeking information and acting as a single brand and hub for all other dissemination activities • A cross-European "hydrogen for society" roadshow with fuel cell vehicles travelling between cities across the EU. The roadshow will form the focal point for a variety of innovative dissemination activities, public debates, co-hosting of national vehicle and infrastructure launches • A robust assessment of of the macro-economic and societal benefits of FCH technologies, providing fact-based analysis used to convey clear messages

Keywords: communication strategy,web portal,benefits,promotion
Amplitudes and form factors via integrability (AFFINITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Our theoretical description of natural phenomena is mostly limited to the regime where the interaction among fundamental particles is sufficiently weak, making the understanding of strongly-coupled gauge theories one of the main challenges of current research in theoretical physics. This proposal aims to study the structure of form factors -- important off-shell generalizations of scattering amplitudes of great phenomenological relevance -- in the maximally supersymmetric Yang-Mills theory at all values of the coupling. Importantly, the strong- and finite-coupling regimes are made accessible by the AdS/CFT correspondence and its integrable structure, respectively. The methods required to achieve the goals of this proposal will extend in a non-trivial way the recent beautiful results in the related field of scattering amplitudes. In particular we plan to derive a precise correspondence between form factors and Wilson loops, to exploit this picture to investigate the strong-coupling regime, and to extract finite-coupling predictions for form factors in the spirit of the recent, powerful OPE approach to scattering amplitudes. Finally we will also analyze the properties of form factors under collinear factorization. This proposal includes a detailed program for the dissemination and communication of its results. The former will mostly be based on seminars and posters at major international conferences, while the latter involves a broad spectrum of outreach activities with diverse audiences ranging from primary school pupils to interested adults. In addition, the proposal includes a detailed training program for the researcher, who will be involved in training courses in scientific management and science communication, and will participate in several scientific workshops and conferences. This wide range of complementary activities is distributed in a balanced way over the duration of the fellowship to maximize the benefit for the researcher.

Keywords: scattering amplitudes,form factors,cft correspondence,integrability,gauge theories,string theory,conformal field theories
Cancer Vaccines and Gut Microbiome: a rational approach to optimize cancer immunotherapy (VACCIBIOME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Italy
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 962500.0
Participants: 2
Project status: SIGNED

This proposal intends to shed light on the interplay between cancer immunity and gut microbiome as a way to optimize personalized cancer vaccines and immunotherapy. The project originates from two milestone discoveries. First, to be effective cancer immunotherapies have to target CD4+/CD8+ T cell neo-epitopes, which originate from tumor mutations. Second, the gut microbiome influences the effectiveness of anti-PD-1/PD-L1 antibody immunotherapy both in animal models and in humans. We also recently showed in a mouse model that oral gavages with Bifidobacterial cocktails improved the therapeutic power of neo-epitope-based cancer vaccines. How microbiome affects anti-cancer immunity has not been fully elucidated yet and a deep understanding of the underlying mechanisms has the potential to substantially improve cancer immunotherapy. Since microbiome antigens are processed and presented by antigen-presenting cells and microbiome-induced T cells represent large fraction of the peripheral T cell repertoire, our hypothesis is that this large repertoire includes T cells which cross-react with cancer neo-epitopes (“molecular mimicry (MM)”). Depending upon the composition of gut microbiome, cross-reacting T cells can positively or negatively modulate anti-tumor immunity. To demonstrate the role of MM in cancer immunity this project intends (i) to select the cross-reactive T cell epitopes as predicted by meta-omics analysis of gut microbiome and exome/transcriptome analysis of cancer cell lines, (ii) to formulate vaccines containing different combination of cross-reactive epitopes, and (iii) to test vaccine anti-tumor activities in normal mice, gnotobiotic mice and mice with engineered microbiome. The ultimate goals are: 1) to provide new criteria for neo-epitope selection in personalized cancer vaccines, 2) to develop prognostic tools based on microbiome analysis, and 3) to define microbial species to be used as immune-potentiators in patients undergoing cancer therapy.

Keywords: cancer vaccines,microbiota,neo epitopes,molecular mimicry
BIOactive implantable CApsule for PANcreatic islets immunosuppression free therapy (BIOCAPAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Cross-cutting and enabling materials technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Belgium,Norway,France,France,France,United States
Call: Biomaterials for the treatment of diabetes mellitus (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2019-09-30
Duration (months): 52.0
Total project cost (EUR): 7998875.0
EU funding (EUR): 7998875.0
Participants: 12
Project status: CLOSED

The key therapeutic issue in diabetes mellitus type I and II is glycaemic control. Reductions of constant self-control, of insulin injections, and of long-term complications would have tremendous benefit for quality of life. The best therapy option is the transplantation of allogeneic islet cells, but the current state of the art limits the applicability of this approach. Implanting unprotected grafts requires lifelong administration of immunosuppressants, and protecting the cells against adverse immune reactions by current encapsulation strategies reduces their functionality and survival to an extend that makes frequent ‘refresher’ implantations necessary. Currently, a maximum of 2 years glycaemia regulation has been shown for the encapsulated approach. In BIOCAPAN, bringing experts from different fields all together, we aim at developing an innovative treatment, based on the implantation of allogeneic islet cells that are embedded in a complex microcapsule. We will design a GMP-grade bioactive microcapsule that will maximize the long-term functionality and survival of pancreatic islets by prevention of pericapsular fibrotic overgrowth, in situ oxygenation, innovative extracellular matrix microenvironment reconstruction and immune-system modulation. We will establish a GMP-grade microfluidic microencapsulation platform to protect freshly harvested islets quickly in a standardized and reproducible way. We aim for full preclinical validation and we will establish a complete protocol in accordance with the provisions of the Advanced Therapy Medicinal Products Regulation, in order to start clinical trials within one year after the end of the project. We aim for 5-years insulin injection free treatment, without immunosuppressants, which would tremendously benefit diabetes mellitus patients who require insulin (all Type I and about one in six Type II Diabetes Mellitus patients).

Keywords: bioactive microcapsule,extracellular matrix reconstruction,oxygen nanocarriers,standardized and reproducible manufacturing,gmp encapsulation platform,nanocharacterization
Climate adaptation in Arabidopsis thaliana through evolution of transcription regulation (TxnEvoClim)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

Differences in gene expression play a key role in generating the phenotypic variability needed for adaptation. During evolution, the coding sequence of genes evolves on average much slower than their expression patterns, thus transcriptional regulation can be especially important for rapid adaptation to new environments. Climate is a major factor for plant adaptation, and both the dispersal of a plant from its native origin as well as climate change will often lower its fitness. Thus, understanding how gene expression patterns are modified to facilitate life in adverse climates would shed light on the trade-offs limiting adaptation. Studying how evolution has shaped plant transcriptomes so that these plants can grow in different ecological niches and their potential to adapt to a changing climate requires a large base of natural variability information. This has recently been accumulated for Arabidopsis thaliana, a model for genetic and evolutionary studies. In the proposed project I will use genomic and transcriptomic data from the A. thaliana 1001 Genomes Project, new measurements of gene expression under water deprivation, as well as newly available data on gene-regulation and field fitness, to define how gene expression is shaped by climate and the genetic potential to adapt to new environments. I will address the following: (1) In natural populations, how do gene expression patterns of individuals correspond to the particular adapted climates? (2) What is the genetic basis for the transcript differences and how is it reflected in modifications to the transcriptional network? (3) Can knowledge of climate-transcript variation relationships be predictive of individual strains more likely to survive in a new climate? As climate is changing due to global warming, the understanding of mechanisms by which plants adapt to climate becomes even more important in agriculture and in natural populations, and this project aims to illuminate the role of a central mechanism.

Keywords: natural variation,transcription regulation,climate change,arabidopsis,fitness prediction
EXPAND - enhancing co-creation in JPI Urban Europe through widening Member State and stakeholder participation (EXPAND)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Coordination and support actions
Countries involved: Austria,Italy,Germany,Cyprus,Sweden,Poland,Slovenia,Romania,Latvia,France,Netherlands,Portugal,United Kingdom
Call: Support to JPI Urban Europe (H2020-WIDESPREAD-02-2016-JPI-UrbanEurope, 2016)
Start date: 2016-09-01
End date: 2019-02-28
Duration (months): 30.0
Total project cost (EUR): 1499998.75
EU funding (EUR): 1499998.75
Participants: 17
Project status: CLOSED

EXPAND intends to support the implementation of the JPI Urban Europe Strategic Research and Innovation Agenda (SRIA) by (1) supporting JPI Urban Europe’s widening activities towards new countries, stakeholders and partners; and (2) focusing on the development and piloting of new instruments, framework conditions and methods for transnational and transdisciplinary cooperation. Since urban transformations to sustainable and liveable futures depends on a broad commitment and co-creation among a diverse set of actors, the identified challenge to be tackled by EXPAND is widening the community. Specifically in terms of member countries. But also in terms of stakeholder involvement in core activities. Furthermore, the challenge is also to be tackled by the development and implementation of new instruments and framework conditions that support such a co-creation and alignment of European, national and local research and innovation actions. As the basic concept for widening participation, a Stakeholder Involvement Platform (SIP) will be developed that anticipates the needs of different stakeholder groups and regions to facilitate the strategic dialogue between all stakeholder groups and implement the SRIA. The SIP relates to new approaches in programme management, alignment of national programmes, strategies and policies as well as new instruments for research funding and new formats for dissemination and exploitation of research results. Strategic relationships will be developed with national, European and international organisations and special attention will be given to reach out and mobilise actors in Widening countries. Two JPI Urban Europe Conferences will be organised to position JPI Urban Europe in the wider European Research and Innovation community and a self-monitoring system will be developed and tested to allow a consistent monitoring of JPI Urban Europe activities.

Keywords: jpi urban europe,widening countries,stakeholder participation,transdisciplinary co creation
Online monitoring of pathogens in times of Corona virus, influenza and legionella - eliminating infection risk for 20 million Europeans (LegioDetect)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Germany
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 3270312.5
EU funding (EUR): 2289218.75
Participants: 2
Project status: SIGNED

WHO declared Legionella as the highest health burden of all water borne pathogens - even for our developed European countries. There are thousands of infections with mortality rates between 5%-30%. Due to similar symptoms like with pneumonia or with flu (fever, coughing and diarrhoea, shivers, headache and body aches) presumed numbers of unidentified and unregistered cases are estimated to be much higher. There is no automated and scalable solution on market which allows the continuous monitoring of in-house water quality regarding detection and quantification of legionella. Current solutions are laboratory procedures, e.g. cell cultivation, which are time-consuming, costly and mostly error-prone, e.g. by detecting no viable-but-non-cultivatable infectious legionella cells. To improve the health safety of all Europeans, including 20 million people currently under concrete health risks, we developed a worldwide unique solution for highly accurate and automated detection and quantification of legionella bacteria in water. Moreover, our system is able to give predictions and warnings already BEFORE critical value is reached, enabling counter measures. LegioDetect is easy to use also for non-experts, data is easy to understand and thus, the system is perfectly scalable for the fast growing market of Legionella monitoring. Our system is intended for owners/operators of rental houses, public buildings or buildings of special interest (e.g. hospitals, hotels, baths or swimming pools), for private households, but also for operators of cooling towers.

Keywords: residential buildings,realestate market,water borne pathogens,metering
Poplar root exudates response to multi-nutrients stress (ExuNutriStress)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

In the face of global changes, agroecosystem productivity is essential both for CO2 fixation and feeding the increasing population. However, plant growth is frequently limited by nutrient availability and in the environment, plants are more often exposed to multiple than single nutrient deficiencies. Plant responses to single nutrient deficiencies have been widely studied while the combined effect of different nutrient deficiencies has been scarcely investigated, particularly for tree species. Root exudates comprise a complex mixture of organic compounds, directly involved in the biogeochemical cycles of nutrients in soils, it can be assumed that their quantity and quality are affected by combined nutrient deficiencies in a different way than under a single one. Thus, this proposal aims to profile Poplar (a fast-growing tree) root exudates under single and combined deficiencies, mainly focusing on: (1) N for macronutrient deficiency as the most often limiting nutrient and on Fe, Zn, and Mn as micronutrients because of their crucial role in photosynthesis, (2) experiments on mineral deficient calcareous soils close to agronomical situations and (3) testing the potential of Poplar root exudates to alleviate nutrient deficiencies in sensitive species such as fruit trees growing on calcareous soils. The applicant has a very strong background in soil chemistry and plant nutrition acquired during her MSc and Ph.D., which together with the experience and facilities of the host and the international supervisory team will lead to the successful completion of this project and the strengthening of the career development of the researcher. The interdisciplinary work involving plant physiology, metabolite profiling, and chemoinformatic tools will lead to (1) improve knowledge about root exudation under nutritional stress and (2) open a new perspective on root-root interactions that can improve plant nutrition.

Keywords: nutritional stress,root exudates,poplar,calcareous soils,root root interactions
Netherlands Researchers' Night: using the innovative Discovery Festival to unite separate events under a new national brand with a strong European dimension (NLRN20142015)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-10-31
Duration (months): 18.0
Total project cost (EUR): 541463.0
EU funding (EUR): 305000.0
Participants: 1
Project status: CLOSED

- Discovery Festival will have its 10th anniversary in 2015, just like European Researchers’ Night. - Discovery Festival has been our Dutch edition of European Researchers’ Night (ERN) since 2006. - We combine new science and young scientists with a high quality young art program and top notch nightlife activities - Thereby we reach the important and difficult target group of young trend setting adults. - We experiment with new ways of communicating science and share our experiences, thus contributing to continuous progress in science communication. - To reach a large broad public, more traditional activities are needed. - In this project, to maximize impact, we will build a framework of diverse new initiatives and existing events, under a new national brand: Netherlands Researchers’ Night. - We use Discovery Festival as a core of continuous innovation. - The shared framework ensures that events will work to adhere to EU quality criteria, that resources are spent effectively and that experiences are shared structurally. - Through substantial support for these events from other parties, the impact of an EU contribution will be multiplied. - We thereby unite a number of separate initiatives under one brand with a strong European dimension. - Discovery Festival 2014 will be the starting point of this process, Netherlands Researchers’ Night 2015 (of which Discovery Festival 2015 will be a part) the first result. - Discovery Festival 2014 will welcome 5.000 visitors in Amsterdam and reach around 2 million people through the awareness campaign. - Netherlands Researchers’ Night will welcome 15.000 visitors on 4 locations, of which 5000 at Discovery Festival 2015, and around 5 million people through the awareness campaign.

Keywords: science experiment art music nightlife innovative trendsetting upscaling centralizing quality