Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Groundbreaking Stand-Alone Diagnostic Kit to Predict Human Papilloma Virus Infections Evolving into Cervical Cancer (HPV OncoPredict)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy,United Kingdom
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-09-01
End date: 2022-04-30
Duration (months): 44.0
Total project cost (EUR): 2945000.0
EU funding (EUR): 2923061.0
Participants: 2
Project status: CLOSED

Cervical cancer (CC) kills a 250,000 people annually, frequently affecting young women, and requires persistent infection with high-risk Human Papillomavirus (hrHPV) for its development. It is preventable, by HPV vaccination and the implementation of population screening programmes, and it is curable if detected and treated early. Despite overwhelming evidence that detection of viral nucleic acids (HPV testing) in cervical cellular samples allows earlier detection of CC as compared to cytology (Pap smear), it is feared that its use as a stand-alone test in CC screening would be responsible for over-diagnosis and over-treatment. HPV OncoPredict is an innovative diagnostic device (IVD) capable of detecting all oncogenic hrHPV genotypes frequently causing cervical infection as well as allowing to accurate identification those 10% of infected women who are truly at risk of developing cervical cancer. With the use of novel viral biomarkers, HPV OncoPredict, starting from a single self- or clinician-collected cellular sample, will enable women to undergo both primary cervical screening and, if HPV-positive, subsequent triage. HPV OncoPredict will allow HPV testing to reliably replace Pap smears in cervical cancer prevention, as recently recommended by European guidelines, being based on a disruptive technology ahead of any competitor’s product and supported by key opinion leaders. The HPV testing market is huge (€315 M) with around 100 million tests performed each year. The consortium formed by GeneFirst and Hiantis, both highly innovative companies with patented technologies, has the capacity to bring HPV OncoPredict to success. HPV OncoPredict will not only shape the manner in which we stratify women at risk of developing cervical cancer, but also provide an accurate and cost effective test of disease to benefit patients. More importantly, it will feed into how healthcare systems implement screening strategies to benefit patient pathways.

Keywords: cervical cancer
BRINGING SURGERY TO THE 21ST CENTURY: REAL-TIME TISSUE ANALYSIS DURING CANCER SURGERY. Improving Patient Safety, Quality and Cost-Effectiveness (Olfactomics Surgery)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-04-01
End date: 2022-12-31
Duration (months): 45.0
Total project cost (EUR): 2649375.0
EU funding (EUR): 1854562.5
Participants: 1
Project status: SIGNED

Currently, cancer tumor removal operation is based on preoperative imaging and postoperative pathological examination. There is a strong global trend towards more tissue-sparing and minimally invasive surgery. If all cancer is not removed in the operation, a reoperation is needed, leading to additional costs, impaired cost-effectiveness and impaired quality of life of the patient. The rate of incomplete removal of a tumor ranges from 10-60%. The breakthrough innovative Olfactomics device allows the surgeon to analyze the operated tissue in real-time during cancer surgery leading to optimal tissue removal without compromising the workflow of the operation and facilitating the use of existing instrumentation. The solution is based on noninvasive, real-time analysis of surgical smoke. The reduced reoperation rate results in significant benefits for the patient, surgeon, hospital and society. The market potential is high. Easily reachable market for the breast cancer surgery is 850M€ and market for other applicable specialties (such as prostate cancer, skin cancer, and intestinal surgery) is over 2,000M€. Olfactomics Oy is a Finnish university-based spinoff company founded in 2015 to commercialize the results of over 10 years of clinical and technical research. The team consists of 13 specialists in surgery, medical technology, software, data analysis, financials and law. The team has excellent connections in the international healthcare industry and sensor technology industry. The technology is currently at TRL 7. The first commercial product for research use will be launched in 2019. This project will focus on scale-up to Olfactomics medical device on breast cancer surgery. The impacts by 2027 include: +3,000 Olfactomics devices sold; +300,000 Olfactomics breast cancer surgeries performed, +70,000 women saved from reoperation, +900M€ costs savings in health care, +100M€ revenue and +200 direct workplaces generated. Scale-up to several surgical areas will follow.

Keywords: real time analysis,oncology,sensor technology,surgical tissue assessment,cancer treatment,breast conserving lumpectomies,cost efficiency,patient care,healthcare
Stability and Sensitivity Methods for Flow Control and Industrial Design (SSeCoID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Spain,Belgium,Sweden,Belgium,Belgium,France,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2025-01-31
Duration (months): 49.0
Total project cost (EUR): 4121912.88
EU funding (EUR): 4121912.88
Participants: 11
Project status: SIGNED

Every day, society is demanding more efficient, safer, affordable and environmental friendly products. To do that, industry needs to innovate by developing new methods and tools able to obtain superior performances of their competitors. This is the main topic of SSeCoID´s research: to develop new methods and tools for design in order to enhance their industrial performance. SSeCoID will demonstrate its innovations by applying the new methods & tools to different problems of aeronautics and mechanical engineering, and will provide very specialized training to 15 researchers to make these novel technologies available to relevant industrial sectors. SSeCoID proposes to work in the: Development of new numerical methods and tools better suited for unsteady flows: stability analysis and high fidelity simulation, capable of capturing and controlling the growth of small perturbations in stable flows and able to provide enhanced accuracy. Identification of the features causing unsteadiness, acoustic, flow detachment or lack of performance of current aerodynamic configurations; Investigation of control/suppression of unsteady flow through flow control devices or surface modifications, by identifying the most suitable zones that have most influence on the flow features; Multidisciplinary evaluation of the most promising applications in relevant problems proposed by industry, including detached flows, acoustic feedback, flow induced vibration, inkjet or race car design; assessment of technical feasibility; potential of control devices for flow instability suppression or delay. Training 15 new researchers in the development of most advanced methods for simulation, feature detection, stability and flow control techniques applied to industrial design. Disseminate the project results in international forums and non-specialized public. Exploit the project results in new patents that include new designs and methods more stable and easy to control.

Keywords: stability analysis,flow control,fluid mechanics,computational fluid dynamics,applied,mathematics for industrial design
Intelligent Motion Control under Industry 4.E (IMOCO4.E)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Spain,Ireland,Italy,Italy,Italy,Germany,Spain,Ireland,Italy,Italy,Italy,Germany,Germany,Spain,Germany,Germany,Germany,Belgium,Finland,Romania,Finland,Switzerland,Finland,Greece,Greece,Latvia,Latvia,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Portugal,Portugal
Call: ECSEL-2020-2-RIA (H2020-ECSEL-2020-2-RIA-two-stage, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 30951318.02
EU funding (EUR): 9072996.63
Participants: 48
Project status: SIGNED

IMOCO4.E targets to provide vertically distributed edge-to-cloud intelligence for machines, robots and other human-in-the-loop cyber-physical systems having actively controlled moving elements. They face ever-growing requirements on long-term energy efficiency, size, motion speed, precision, adaptability, self-diagnostic, secure connectivity or new human-cognitive features. IMOCO4.E strives to perceive and understand complex machines and robots. The two main pillars of the project are digital twins and AI principles (machine/deep learning). These pillars build on the I-MECH reference framework and methodology, by adding new tools to layer 3 that delivers an intelligible view on the system, from the initial design throughout its entire life cycle. For effective employment, completely new demands are created on the Edge layers (Layer 1) of the motion control systems (including variable speed drives and smart sensors) which cannot be routinely handled via available commercial products. Based on this, the subsequent mission is to bring adequate edge intelligence into the Instrumentation and Control Layers, to analyse and process machine data at the appropriate levels of the feedback control loops and to synchronise the digital twins with either simulated or real-time physical world. At all levels, AI techniques are employable. Summing up, IMOCO4.E strives to deliver a reference platform consisting of AI and digital twin toolchains and a set of mating building blocks for resilient manufacturing applications. The optimal energy efficient performance and easy (re)configurability, traceability and cyber-security are crucial. The IMOCO4.E reference platform benefits will be directly verified in applications for semicon, packaging, industrial robotics and healthcare. Additionally, the project demonstrates the results in other generic “motion-control-centred” domains. The project outputs will affect the entire value chain of the production automation and application markets.

Keywords: motion control,mechatronics,digital twins,machine learning,edge to cloud computing,computer vision,robotics,human cyber physical systems,secure communications,predictive maintenance
COOPeration of bioeconomy clusters for bio-based knowledge transfer via Innovative Dissemination techniques in the primary production sector (COOPID)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Austria,Spain,Finland,Bulgaria,Poland,Greece,France,Denmark
Call: A network of European bioeconomy clusters to advance bio-based solutions in the primary production sector (H2020-FNR-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 1999994.95
EU funding (EUR): 1999994.95
Participants: 12
Project status: SIGNED

Bioeconomy starts on the fields, yet meaningful participation of the primary sector in the bioeconomy is currently challenged, especially due to: (i) poor cooperation and knowledge transfer between relevant stakeholders, (ii) limited support to invest in R&D of new value chains. To answer this challenge, the COOPID project proposes an effective strategy to mobilise primary producers and stimulate the uptake of inclusive and sustainable bio-based business models in the European primary production sector, considering regional & sectorial conditions. To do so, a network of COOPID Bioeconomy Clusters from 10 European countries has been created ad-hoc, involving a range of stakeholders: (a) primary producers, in cooperatives or associations, within agriculture, forestry & aquaculture, (b) industry, (c) public sector, (d) research & academia. We have already the commitment to participate of 73 entities. We will foster the deployment of innovative bio-based business models in the primary production based on a four-level knowledge transfer approach: -Selecting “Success Story Showcases” across different EU countries among the network which will be visited in person by the participants from the network - “COOPID ambassadors”- (level 1), -Organising workshops to be done by the “COOPID ambassadors” for sharing main highlights of their visit to the “success story” among their peer primary producers (level 2), -Carrying out interactive dissemination & communication engaging other target audiences (levels 3&4). Focus will be put on mobilisation of female and young producers as having a great potential to innovate yet being underrepresented in the primary production sector. Recommendations for primary producers, policy-makers and academia & research will be elaborated, fostering better understanding of different perspectives on bioeconomy, having a significant impact on a wide bioeconomy deployment in primary production, reaching a broad audience (estimated at 9,500 stakeholders).

Keywords: bioeconomy cluster,innovative business model,primary production,knowledge transfer,ambassador,peer to peer dissemination
Dissecting the role of thymic epithelial cells in T lymphocytes maturation during human foetal development (ThymEForT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-01-05
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The thymus plays an essential role in the establishment of adaptive immunity and central tolerance as it provides a nurturing environment for the differentiation of T cells, a process orchestrated by their interaction with multiple cell types. Despite advances in the knowledge of human thymus, how it functionally develops during foetal life remains elusive. This project aims at dissecting molecular mechanisms responsible for functional maturation of T cells by recapitulating human foetal development within a novel in vitro 3D system. Stromal and T cell compartments will be isolated and characterised at relevant developmental stages before and after mature T cells appear to underpin when thymic stroma acquires competence to sustain T cell development. Stromal populations from relevant developmental stages will be expanded in vitro to be cocultured with T progenitors within a unique 3D thymic natural matrix developed by the host lab. Repopulated 3D scaffold is sliced according to clinical grade protocols and cultured, allowing to set up multiple coculture conditions with the same stroma and compare the output on T cell maturation. In parallel, foetal thymic epithelial cells will be genetically modified to determine the role of specific transcription factors important for T cells onset during development. Recently developed microfluidic devices will provide an additional layer of information regarding molecular mechanisms regulating the crosstalk between stromal and immunological compartments. I anticipate to recapitulate human T cell development within a novel, whole human 3D in vitro culture system, to tackle fundamental immunological questions regarding human thymus development including maturation of tolerogenic T cells and regulation of central tolerance. Last, new key molecular and cellular players for T-cell specification will be uncovered opening new avenues for both congenital immune deficiencies based upon correction of the underlying molecular defect.

Keywords: human foetal development,thymus,aire 1,t regs
Biostimulants nanoencapsulation to increase yield under drought stress (NANOSTIMULANTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

A biostimulant (BS) is understood as any compound, microorganism or mixture of them, with the exception of fertilizers and pesticides1. BSs are commonly ecofriendly substances and inert for the ecosystems, their utilization is widely reported in the literature as enhancing tolerance against stress or increasing yield in the field2. Regarding plant health, BSs are presented as a good alternative to achieve the yearly EU goals announced in the communication: “A Farm to Fork Strategy for a fair, healthy and environmentally-friendly food system” 3. A good example of this way of thinking is the research conducted by the experienced researcher (ER) of this proposal, through utilizing L-pyroglutamic acid 4 (Pyr), which is able to save 30% of water requirements, reaching higher yields. However, to be effective, weekly treatments of 500 g per hectare are required. These involve an extra cost per hectare of 20€ each week to reduce watering by 30% with some losses in yield. One of the main reasons is probably the easy degradability of BSs. Indeed, application of pure bioactive compounds is also very limited due to their fast release, low solubility, and poor bioavailability5. An alternative to counteract these disadvantages is nanoencapsulation6. The present proposal is a novel interdisciplinary approach to this, which aims to multiply BS effectiveness by constructing a Nanostimulant (nanoparticle that encloses a BS). It updates traditional BS applications in the field by using the most advanced nanoencapsulation (NE) techniques.

Keywords: biostimulants,agroindustrial,food security,climate change,water deficit
Open access pilot plants for sustainable industrial scale nanocomposites manufacturing based on buckypapers, doped veils and prepregs (PLATFORM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Efficient and sustainable synthesis and manufacturing of nanomaterials, components and systems
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Italy,Spain,Greece,Poland,Belgium,Poland,United Kingdom
Call: Open access pilot lines for cost-effective nanocomposites (H2020-NMP-PILOTS-2014, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 7797727.5
EU funding (EUR): 7797727.5
Participants: 15
Project status: CLOSED

Two FP7 European projects ELECTRICAL and SARISTU aim to develop methods to manufacture CNT reinforced multifunctional composites compatible with current industrial manufacturing processes. According to the results, three CNT integration strategies appear as promising methods to be driven towards an industrial scale manufacturing process: buckypapers, CNTtreated prepreg and CNT doped nonwoven veils. Although each of the technologies can act separately they can be combined synergistically in a way that a higher multifunctional level can be achieved according to the final requirements of the application. This project aims to develop open access pilot lines for the industrial production of buckypapers, CNT treated prepreg and CNT doped non-woven veils for composite applications in sectors such as Aeronautic and Automotive. The purpose is to efficiently and economically manufacture components using novel developed at a scale suitable for industrial uptake. The developed facilities will not only provide increased capabilities to the operating company but also offer a network of nanorelated manufacturing facilities suited to the needs of related SMEs. A European platform of nanobased pilot lines will be created to which companies, and more precisely SMEs, can gain access and make use of the facilities as well as the experience and knowledge of the operating RTO.The partners will work with existing EU clusters and initiatives aimed at the establishment of an EU nanosafety and regulatory strategy framework to ensure the safe use of these products particularly at an industrial scale. This will be achieved through collaboration with end users to ensure the developed products are accepted within existing health and safety procedures or through the introduction of new ones.PLATFORM proposes solutions that will generate new market opportunities for European Aeronautic and Automotive components manufacturing offering to OEMs new added-value products based on nano-enabled products

Keywords: pilot line,nano enabled product,buckypapers,cnt treated prepreg,doped veil