Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Symbiotic, circular bioremediation systems and biotechnology solutions for improved environmental, economic and social sustainability in pollution control (SYMBIOREM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Italy,United States,United Kingdom,Sweden,Poland,Netherlands,Belgium,Cyprus,Austria
Call: Environmental services: improved bioremediation and revitalization strategies for soil, sediments and water (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2026-11-30
Duration (months): 51.0
Total project cost (EUR): 4735793.75
EU funding (EUR): 4735793.75
Participants: 19
Project status: SIGNED

The overall goal of SYMBIOREM is to improve the effectiveness, sustainability, circularity and cost-efficiency of bioremediation and revitalisation strategies for soils, sediments, surface water and groundwater. SYMBIOREM focuses on the intersection of advanced bioremediation methods with circular bio-based systems. Twelve novel bio-based technologies and strategies are developed as modular solutions to mutually enhance bioremediation efficiency, use secondary inputs, and turn residues and contaminants into valuable resources. SYMBIOREM investigates the exploitation potential of indigenous species with bioremediation capabilities, including microorganisms, microbiomes, proteins, plants and animals. SYMBIOREM targets five archetypes of contaminated environments: industrial brownfields, mixed solid waste landfills, urban surface water bodies with mixed contamination, contaminated soils and surface water bodies, and European marine environments. SYMBIOREM targets the four most common pollutants of soil and groundwater in Europe: heavy metals, mineral oil, Polycyclic Aromatic Hydrocarbons (PAH) and Volatile Aromatic Hydrocarbons (VAH). The project also targets mixed contamination, eutrophication, organic micropollutants and microplastic. SYMBIOREM recovers a diverse portfolio of resources from contaminated sites, including several Critical Raw Materials (CRM). SYMBIOREM will deliver new knowledge about bioremediation agents, their functionality in combination, as well as hazards of pollutant remobilisation. SYMBIOREM elaborates new avenues for circular value creation and empowers people on the ground by involving citizens and key stakeholders in participatory research, co-design and co-management of bioremediation sites, to facilitate bottom-up replication and increased safety and sustainability of bioremediation and revitalization strategies in aims to achieve the targets of the EU Zero Pollution Action Plan.

Keywords: bioremediation,circular economy,persistent pollutants,biotechnology,phytoremediation,molluscs,soil,water,sediment,community engagement
StreP (Stretchable PV foil) (StreP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

CO2 neutral energy generation is needed for climate change. PV can solve a large portion of this need. In densely populated areas, the use of land is scarce and therefore PV integrated in the built and living environment is preferred to make double use of land area. Flexible PV sheets already exist, but the present PV sheets cannot be stretched or elongated like textile that is placed under stress. The existing PV sheets can be rolled and bended, but not elongated, which is important when the PV sheets would be integrated into e.g. the architectural textile. This project aims to solve this problem by making the interconnection between the solar cells stretchable. This would open many opportunities to integrate these PV foils in applications where the flexible sheets are placed under severe mechanical stress or tension. In this project we will use flexible CIGS PV cells, which are also used in the present flexible PV modules. To allow stretching of the foil under mechanical stress, it requires a special interconnection technology. A patent pending technology has been developed to create a series interconnection between the flexible solar cells, that at the same time can be stretched several millimeters, so that an elongation of 3 to 10% of the PV foil would become possible. This would be new and opens the possibility to integrate the PV foil in any tent-like structure. Applications we foresee are: - PV integrated in tents for refugee camps. Integration of the PV on the tents itself, will create immediately energy generation at the moment of setting up the tents. - Agricultural PV is a fast-expanding PV segment. For this application, the resistance to wind pressure is an important factor and stretchable PV would be a solution to overcome that problem. - Architectural textile is used for making domes to cover sport or other large infrastructure (with dimensions up to 600m x 400m). These large roof surfaces would be ideal to generate part of the CO2 neutral energy.
The Mouse Village: a fully automated behavioral system for continuous social and cognitive testing (MOUSEVILLAGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Drug discovery in mental health is undergoing a crisis. Characterizing a new generation of biomarkers for the different disorders seems the promising path towards developing new treatments. Biomarkers, including behavioral biomarkers, are quantitative observables that are altered and can be used for diagnosis, prognosis or treatment response monitoring. Importantly for preclinical research, these biomarkers should be translational and work across species, but experiments in rodents are largely based on paradigms that are disparate from those used in humans. Training rodents in more human-like tasks has a strong translational potential, but it has important shortcomings: it requires developing finely-controlled tasks involving long training periods, consuming lots of animals and ultimately inducing very elevated personnel costs. To confront this experimental bottleneck , neuroscience and pharmaceutical laboratories are trying to automatize their methods, but still most systems rely on human intervention, require animal manipulation and impose a high maintenance toll. Leveraging our experience building behavioral systems during our ERC-CoG-2015, we will design, build and distribute the Mouse Village (MV), a new fully-automated open platform in which mice self-trained 24/7 in different cognitive tasks while displaying complex social interactions without human intervention. The MV consists in a system of cages connected to an operant touchscreen chamber that can implement multiple cognitive tasks. We will build on a previously developed pilot MV by introducing a more modular and flexible design and validate the system using several standard social and cognitive tests. The MV will be shared to the community under and Open Software and Hardware licenses. By eliminating the experimental bottleneck imposed by behavioral experiments, the MV has the potential to accelerate the search for new biomarkers of brain disorders and have a substantial impact on mental health.
Disentangling Vertical Land Motion Processes for Future Sea Level Change Projections (VLM-SLC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 424992.0
EU funding (EUR): 424992.0
Participants: 2
Project status: SIGNED

As one of the most direct effects of climate change, sea level change will have drastic consequences for coastal populations, industries, and ecosystems in the coming century. Coastal relative sea level change is additionally driven by vertical land motion, which can be as large as climate-driven absolute sea level change (mm/year - cm/year) and is expected to have similar impacts as climate-driven sea level rise in the short term (~30 years). However, there is only ‘low to medium confidence’ in state-of-the-art vertical land motion projections and their uncertainties at the global scale. This is because the majority of previous sea level projection studies employed simplified assumptions of vertical land motion, i.e., they used limited data sources, neglected the full spectrum of vertical land motion processes (e.g., tectonic or human induced effects, etc.), and did not consider non-linear changes, which are crucial to understand the predictability of vertical land motion. To overcome these limitations, I propose here an interdisciplinary approach, to develop a probabilistic spatio-temporal model that will provide estimates of vertical land motion at unprecedented spatial and temporal resolution (from 1900 to present). This will be the first global-scale effort to integrate paleo-sea-level records, modern measurements (e.g., GNSS (Global Navigation Satellite System), tide gauges, InSAR (Interferometric Syntethic Aperature Radar), satellite altimetry), physical models (e.g., GIA models), and ancillary information from climate models. I hypothesize that combining these different data sources is key to disentangle vertical land motion processes, such as GIA, tectonic, and other natural or human-induced effects. The outcome of this project will be process-based vertical land motion projections on a global scale that distinguish between long-term linear motions and non-linear effects, and that include rigorous uncertainty quantification.

Keywords: sea level change,vertical land motion,relative sea level change,gnss,insar,satellite altimetry,tide gauges,sea level proxies,glacial isostatic adjustment,tectonics,projections
Full eurOpean hdi pCb and assembly sUpply chain for Space and INdustrial seGments (FOCUSING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Italy,Denmark,Austria,France
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 2712954.75
EU funding (EUR): 2712954.25
Participants: 6
Project status: SIGNED

FOCUSING is a powerful playground in which outstanding, worldwide recognized European companies with complementary expertise and state-of-the-art facilities will share and merge their experience with the ultimate goal of exploring and exploiting novel green-oriented routes towards the significant upgrading of the current printed circuit board (PCB) and surface mount technology (SMT) and the enhancement of the overall European competitiveness. Even though space market is addressed in priority, other applications may be addressed. The growing trend towards miniaturization and the demand of ever more compact and integrated devices have led to an ever increasing interest in printed circuit board with embedded components and in HDI boards, both for the multiple potentialities of a technical-productive nature, and for the encouraging growth prospects of the market demand. Despite improved manufacturing HDI technologies have been widely demonstrated, and exploited e.g. for automotive, biomedical, and commercial applications, incorporating these improvements in capability with space reliability requirements still representing a challenge. In this project, HDI technology is considered pivotal for the integration of cutting-edge electronic solutions able to revolutionize the design of present and future products (e.g. from standard sized to micro and nano satellites) by reducing the payload and boosting the performances of the space equipment. The objective of the proposed activity is double : • To develop and validate state-of-the-art building blocks to demonstrate the reliability of the technologies and processes developed • To build a fully European competitive, sustainable and independent supply chain based on state-of-the-art laminates and cutting-edge HDI PCB manufacturing technology focused on advanced Space applications but potentially benefiting as well to other applications.

Keywords: hdi,pcb,assembly,supply chain,space,industry
Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses (JANUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1998430.0
EU funding (EUR): 1998430.0
Participants: 1
Project status: SIGNED

In an ever-changing natural world, animals must constantly adapt their behavior by extracting relevant information from the environment in a context-dependent manner. This is a complex task because the relevance of sensory stimuli rapidly changes according to the animal’s internal states, evidence, attention and goals. In the brain, neuromodulatory systems are thought to encode environmental and internal signals, such as novelty, reward, effort and risk, providing critical input to ensure appropriate action selection. However, classically, neuroscientists have opted to study sensorimotor transformations as a reflex arc, largely ignoring complex modulatory contributions due to their experimental inaccessibility. In this proposal, I will explore the neuromodulatory strategies used by the brain to tailor sensorimotor computations according to the immediate needs of the animal. A key node for sensorimotor transformation and spatial attention is the Superior Colliculus (SC). The SC is also a neuromodulatory hub, where retinal streams converge with highly diverse and functionally mysterious neuromodulatory inputs. Here, I will take advantage of the SC’s role as a gatekeeper in sensory processing and behavioral control to unravel the multiplexed logic and function of neuromodulation. To do so, I will first quantitatively describe SC’s visual and non-visual dynamics on a moment-by-moment basis and define their interactions. Next, I will determine the properties, orchestration and influence of SC’s neuromodulatory inputs on sensory processing, goal-directed behaviors and spatial attention. Finally, I will describe the role of neuromodulation mechanistically by developing a novel functional connectomics approach and mapping circuit motif changes. Given the implication of neuromodulation in brain disorders, this work will shed light on the tight orchestration of neuromodulation that ensures appropriate or abnormal selection of actions, according to the animal’s immediate needs

Keywords: sensorimotor transformation,vision,neuromodulation,superior colliculus
Developing and implementing innovative Patient-Centred Care Pathways for cancer patients (MyPath)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Switzerland,United Kingdom,Italy,Belgium,Spain,Denmark,Romania,Netherlands
Call: Improved supportive, palliative, survivorship and end-of-life care of cancer patients (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 4773470.0
EU funding (EUR): 4773470.0
Participants: 17
Project status: SIGNED

In the EU, 2.7M people were diagnosed with and 1.3M died of cancer in 2020. Over 12M people have survived cancer, thanks to advances in early detection and new therapies. With higher cure rates and more patients living longer with cancer, access to patient-centred care consisting of optimal supportive, palliative, survivorship and end-of-life care becomes increasingly important. However, cancer care still has silos, and to this day, there is no technical support available that is suitable for different cultures, settings and environments. Several randomised controlled trials have provided evidence that the integration of patient-centred care in standard oncology care results in better patient and caregiver outcomes. As yet, these findings have not translated into clinical routine. In this project, we will develop technology-enhanced and evidence-based patient-centred care pathways, called MyPath, to be merged with tumour-centred treatments across supportive, palliative, survivorship and end-of-life care. MyPath integrates patient-reported outcomes of the OUS Eir software, to be further advanced with contributions of renowned European oncologists, ethicists, psychologists and sociologists. It will be configurated on the eHealth platform of our SME partner DNV Imatis. Its effectiveness and sustainability will be assessed in an implementation science study in 9 clinical centres across Europe. With the support of leading cancer care professional associations ESMO and EAPC, we are committed to delivering the right care to the right person at the right time by the right persons. We hypothesise that MyPath can significantly improve the quality of and access to treatment and care, reduce variations in clinical practice, and optimise resources in family, community, and hospital care settings. This will ultimately reduce the physical, emotional, and ultimately economic burden linked to cancer.

Keywords: patient empowerment quality of life patient reported outcomes care pathways cancer care patient centred care digitalisation implementation science ethical,legal and socio economic aspects
Establishing Exhaled Breath Aerosol (XBA) sampling for diagnosis and screening of respiratory infections (BreathForDx)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Italy,South Africa,Romania,Switzerland
Call: Pandemic preparedness (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2252746.25
EU funding (EUR): 2252746.25
Participants: 5
Project status: SIGNED

Respiratory infections resulted in >7 million deaths in 2020 and were responsible for 7 of the last 9 pandemics, causing trillions of €s in economic losses. Despite the importance of early detection for individual health and pandemic control, flawed sampling methods for respiratory infections limit the impact of highly-sensitive molecular diagnostics. BreathForDx’s overall goal is to tackle this problem by establishing exhaled breath aerosol (XBA) as a novel, evidence-based sample for respiratory infections in three use cases: diagnosis, screening, and antimicrobial resistance, using tuberculosis (TB) as a model infection. The project will leverage innovation in bioaerosol and material science, as well as the multidisciplinary (including academia, industry and NGOs) consortium’s track record of delivering transformative diagnostic innovation. More specifically, we will optimise an innovative, easy-to-use, scalable XBA sampling device, and compare it to a face mask sampling device coupled with rapid molecular detection in three clinical studies. We will evaluate the XBA sampling efficiency of these devices using the Respiratory Aerosol Sampling Chamber as a benchmark. Next, we will assess performance of the devices for diagnosis of TB and drug-resistance among symptomatic patients in a high burden EU country. In parallel, we will assess the feasibility of multiplexing XBA samples for multiple respiratory pathogens (i.e., TB, influenza, SARS-CoV-2) in a screening use case. Accuracy and feasibility data will be complemented by data on acceptability and usability, as well as cost-effectiveness and impact modelling to inform the implementation potential of the novel devices across different use cases. We envision a world in which a single breath sample, coupled with point-of-care molecular diagnostics, enables accessible and accurate pathogen and resistance detection of highly transmissible respiratory infections, thereby improving both individual and public health.

Keywords: diagnosis,respiratory infections,bioaersols