Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications (ALERT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 3976320.0
EU funding (EUR): 1988160.0
Participants: 1
Project status: CLOSED

The current overuse of antibiotics is leading to the emergence of multidrug resistant (MDR) bacteria. These MDR pathogens continue to evolve at a terrifying rate and confer resistance to most or all presently available antibacterial treatments. Antimicrobial resistance is an eminent global problem that calls for an integrated approach that surpasses national borders, sectors, and disciplines. The COFUND ALERT programme addresses this call by establishing a dedicated doctoral training programme with an international, interdisciplinary and inter-sectoral focus. Nineteen excellent Early Stage Researchers (ESRs) will be employed at the University of Groningen (RUG). ALERT is based at RUG but is tightly connected with multiple international academic and private partner organisations, each providing complementary research or training. ALERT aims to develop the best practices in high quality training and research. ALERT achieves this through advanced multidisciplinary research training extended with development of dedicated transferable and entrepreneurial skills. ESRs will develop novel antimicrobial drug candidates through chemical, biotechnological and nanotechnological synthesis and subsequent in vivo testing. All ALERT Principal Investigators have ample experience with supervising PhD students, which ensures an attractive and vibrant research environment for the ESRs. In addition, access to excellent modern research facilities is guaranteed. Thus, the ALERT programme creates an optimal research and training environment that is far greater than the sum of its individual parts. ALERT’s long-term ambitions are to establish a strong and coherent international network that links together highly skilled young researchers as well as established scientists, who far beyond the funding period will continue to inspire each other to excel in antimicrobial resistance research in order to tackle the antimicrobial challenge.

Keywords: antimicrobial compounds,synthesis,multidrug resistance,doctoral training,multidisciplinary
An autonomous and mobile water treatment plant powered by solar energy (WATLY)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Water and energy are highly interdependent and are both crucial to human well-being and sustainable socio-economic development. In 2014, the UN reports that 768 million people worldwide still do not have access to a safe source of drinking water, and more than 1.3 billion lack access to electricity. We have developed the Watly® unit with the goal of providing a solution for fast, simple and efficient wastewater treatment and energy supply in developing and/or remote regions. Watly combines cutting-edge technologies to offer i) complete sanitation for well, surface ground, sea or recycled rain water, ii) off-grid electricity from solar energy and iii) Wi-Fi internet connectivity, all in one portable autonomous unit. Watly embodies the ambition of a European company to address a global market. The wide range of customers worldwide that could benefit from this all-in-one solution include diverse market segments such as: Governments and public institutions, Non-Governmental Organizations (NGO) and foundations, mobile hospitals, military organizations, hotels/resorts/businesses in remote destinations, massive open-air events, oil platforms, gas/oil & construction sites, etc. Scale-up beyond our current prototypes and industrialization of the production process is the key to growth and expansion of our company taking advantage of a new market opportunity. In order to do so, we are applying for SME Instrument Phase 1 funds to: (i) elaborate an exhaustive technical feasibility study focused on scale-up beyond our current prototypes, design and industrialization of the final commercial unit of Watly-L; (ii) elaborate a detailed business plan for the commercialization of Watly-L at the conclusion of the envisaged Phase 2 project. If the results of the feasibility study, both from the technical and commercial point of view, are positive, we will proceed to apply for Phase 2 funds in order to carry out the abovementioned scale-up, product refinement and industrialization tasks.

Keywords: environment,water sanitation,wastewater treatment,renewables,solar energy,off grid electricity,internet connectivity,eco innovative technology,place and play,resource efficiency
Hydrocarbon Oxidation Mechanisms Elucidated from Radical scavenging (HOMER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-04
End date: 2018-04-03
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Oxidation reactions of hydrocarbons are of central importance to both atmospheric and combustion chemistry, where they play a pivotal role in determining the capacity of a hydrocarbon to persist in the air or burn as a fuel. However, quantitative and complete measurements of the mechanisms by which oxidation occurs are very uncommon. Yet it is these mechanisms that ultimately determine the chemistry, influencing such diverse processes as tropospheric ozone production, secondary organic aerosol formation, soot formation and autoignition of fuels. Conventional approaches typically involve mimicking atmospheric or combustion conditions within a chemical reactor. Common to both of these chemical regimes are the phenomena of radical chain propagation, radical–radical reactions and multiple reaction pathways, leading to complex reaction mixtures that evolve rapidly with time. Subsequent gas samples are subjected to detailed and often ambiguous interpretation, placing high demands on detailed chemical models in which only a small proportion of the reactions described within underwent direct experimental measurement. This fellowship seeks to challenge these existing approaches with an alternative methodology in which the short-lived initial products of oxidation, the alkyl radicals, are rapidly converted into stable halogenated species before reaction mixtures become complex, providing crucial information on the fundamental reaction steps at work in these systems. These mixtures will be analyzed by conventional, low cost gas-chromatography methodologies, where the inherent sensitivity and discriminating power of the electron-capture detector towards halocarbons will be exploited. By combining this technique with recent insights into radical scavenging using molecular halogens, a unique and diverse apparatus emerges, which will be used to interrogate several classes of reaction.

Keywords: tropospheric chemistry,air quality
Flexible RTM tool with automated distortion correction (FLEX)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Greece,France,United Kingdom,United Kingdom,United Kingdom
Call: Flexible RTM tool concept for composites with spring back adjustments capabilities (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 1399757.5
EU funding (EUR): 1399757.5
Participants: 6
Project status: CLOSED

The FLEX proposal answers to the scope of JTI-CS2-2017-CfP07-AIR-01-33 call on the topic “Flexible RTM tool concept for composites with spring back adjustments capabilities”. The high-level challenge FLEX project will be addressing is to develop the next generation RTM tooling that can be easily adjusted to account for part spring back effect. The main aim of the project will be to design an RTM tooling system that will feature decreased lead times and increased productivity. It will feature a novel distortion compensation capability based on actively changing the mould shape. The process is driven by accurate modelling of the spring back effects thanks to simulation of the phenomenon by analytical surrogate models. The mould will feature automation procedures in every production step. Areas of investigation will be the preform/fibre placement, the resin injection process and mould cleaning. It will also feature an advanced monitoring system that will offer unparallel quality assurance. The technologies will be initially demonstrated on a small scale mould that will feature all complexities of a real production piece. The final tool will be built according to the specification of the Topic Manager, verified for compliance and functionality and delivered to its premises. Overall, FLEX will advance its technologies from TRL3 up to TRL5 and potentially reach TRL6. Within the project, the integrated system (tooling and technologies) will be developed and validated in relevant environment, thus TRL5 will be achieved upon its completion. The Call requires, the delivery of the demonstrator at the Topic Manager premises, so that TR6 will be achieved post- project within the Airframe ITD.

Keywords: spring back compensation,composite materials processing,moulds,process automation,flaperon,tooling manufacturing and verification testing
Ecologically and economically sustainable mesopelagic fisheries (MEESO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Research and Innovation actions
Countries involved: Ireland,Iceland,Spain,Ireland,Ireland,Sweden,Norway,Norway,Norway,France,Netherlands,Denmark,United Kingdom,Denmark,United Kingdom,United Kingdom,Portugal
Call: Sustainable harvesting of marine biological resources (H2020-BG-2018-2, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 6396633.75
EU funding (EUR): 6396633.75
Participants: 20
Project status: SIGNED

The overall goal of MEESO is to quantify the spatio-temporal distributions of biomass, production and ecosystem role of mesopelagic resources and to assess options to sustainably manage and govern their exploitation. To reach this goal, MEESO will create new knowledge and data on the mesopelagic community, its biodiversity, drivers of its biomass, its role in carbon sequestration, its role in the oceanic ecosystem and its interactions with the epipelagic community which includes several important commercial fish stocks. Besides applying state of the art experimental and quantitative methods, MEESO will develop and implement new acoustic and trawling technologies necessary for the knowledge and data generation in relation to this largely unknown and remote part of marine ecosystems. MEESO includes a significant amount of in-kind financing for technology development and scientific surveys. MEESO will apply the new knowledge and data to determine the potential of the mesopelagic biomass to be sustainably exploited for products included in the human food chain. For the first time combining leading experts in science, engineering, fisheries and governance, MEESO will develop commercial fishing and processing technologies and mapping of contaminant and nutrient contents to explore the basis for a viable fishery and creation of jobs. Mesopelagic organisms represent one of the largest unexploited resource left in the world's oceans, with a recent biomass estimate at 10 billion metric tons. The new tools and technologies, as well as assessment and management roadmaps, developed in MEESO will establish the trade-offs between exploitation, sustainability and viability of the resource, and identify options for its governance.

Keywords: mesopelagic ecosystems,biodiversity,biomass,production,climate,fisheries,stock assessment,management,governance,fishing and processing technology,feed and food safety,outreach
Connecting neural networks: Nervous-system-on-Chip Technology (CONNECT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Belgium,Finland,Netherlands,Netherlands,Netherlands,United Kingdom,Luxembourg
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 6807867.5
EU funding (EUR): 6807867.5
Participants: 7
Project status: SIGNED

Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model in Parkinson’s Disease. This provides CONNECT with novel insights, thereby paving the way for future development of therapeutic strategies.

Keywords: brain organoid,neurodegenerative diseases,parkinson s disease,neuroelectric interface,microfluidics,midbrain,ipscs,stem cells,neuronal,tissue engineering,organs on chip
Molecular control of DNA replication timing in mammalian cells (RepTime)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 1999784.99
EU funding (EUR): 1999784.99
Participants: 1
Project status: SIGNED

DNA replication is an essential process ensuring the transmission of genetic information and is highly regulated. Specifically, the DNA replication-timing program ensures that the sites of initiation of DNA replication, termed origins, are not all activated simultaneously but follow a cell-type specific schedule. This pathway is conserved throughout eukaryotic evolution, however its molecular control and biological role are not fully understood. In this proposal I aim to understand key aspects of replication-timing program by employing a combination of advanced mouse genetics, genomics, cell biology and proteomics. Currently one of the major limitations in the mammalian DNA replication field is the elusive identity of origins. I aim to comprehensively map origins in a variety of mouse cells/tissues and relate the regulation of origin firing to the control of gene expression and three-dimensional nuclear architecture. I have discovered that Rif1 controls replication timing and links it to nuclear three-dimensional organization. I have also revealed the existence of a novel Rif1-independent pathway that controls the timing of a significant fraction of the late-replicating genome, identified by constitutive association with a key nuclear architecture component, Lamin B1. Here, I propose complementary approaches to understand the molecular mechanism by which Rif1 coordinates replication timing and nuclear organization as well as the molecular underpinnings of the novel pathway instructing late-replication in Lamin B1-associated regions. Finally, my goal is to understand the in vivo biological role of the replication-timing program. Our preliminary data identify mammalian X inactivation as a process where replication timing may play a fundamental part. My ultimate objective is to contribute to the realization of a comprehensive understanding of nuclear function, integrating the co-regulation of DNA replication with gene expression, epigenetic inheritance and DNA repair.

Keywords: chromosome biology,nuclear organization,dna replication
Evolution of pro- and eukaryotic commensals within the human gut (EPYC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499993.0
EU funding (EUR): 1391698.0
Participants: 2
Project status: SIGNED

The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations. The gut microbiome is important for human health, supporting nutrition, pathogen defence and immune homeostasis, with more than 200 species inhabiting each human gut. In recent years metagenomics led to notable breakthroughs in describing this microbial diversity, yet 50-90% of species are typically present at too low abundance to be genome or strain resolved. Thus, most gut microbiome studies focused to date on dominant bacteria and very little is known of the highly diverse, yet low abundance, pro- and eukaryotes (elusive microbes). Importantly, elusive microbes are an inherent part of ecosystem successions persisting at different ages of the host. I propose that niche adaptation and persistence are key indicators of a taxa’s importance to the gut ecosystem and host health. I will determine which microbes persist for years within a human, or even a family for several generations. This should be reflected in microbial genetic adaption, also indicating which genes are likely important to successfully colonize the human gut. I hypothesize that low abundance pro- and eukaryotes are adapted to persist for multiple generations in the human host, indicating their importance, despite being largely ignored so far. To investigate this knowledge gap in EPYC, I will (O1) Enable high-precision metagenomics of elusive microbes (O2) Estimate pro- and eukaryotic strain persistence across three human generations (O3) Describe the microbial genetics of gastrointestinal persistence EPYC will develop the next-generation of high-resolution metagenomics of an extended taxonomic range, enabling me to research microbial evolution in the human gut.
Disruptive personalized pre-operative planning tool for transcatheter procedures (HEARTguide)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 4682512.5
EU funding (EUR): 3214583.75
Participants: 1
Project status: CLOSED

While transcatheter procedures for heart structural diseases present strong advantages over open-heart surgeries, their adoption remains low. Indeed, the difficulties to predict the optimal size and positioning of the heart implant cause high rate of complication. FEops has developed HEARTguide, a cloud-based pre-operative planning tool that will enhance the use of the transcatheter procedures. HEARTguide simulates virtually the interactions between the implant and the real patient anatomy. HEARTguide predictive power was shown in a retrospective clinical trial on 80 patient cases. HEARTguide is CE marked for two indications. The next generation of HEARTguide will be artificial intelligence-powered and the analysis will be automated. The enhanced platform will be clinically validated through four clinical trials including 700+ patients and limited access releases with selected physicians. The data base contains 1000+ patient data that surpasses all over tools marketed. Agreements have been established with several worldwide implant manufacturer leaders to run feasibility studies and clinical trials. The commercial launch of HEARTguide is planned for 2024 and intends to be clinically validated for four different applications. HEARTguide will be marketed in EU, US, China and Japan following market approvals by the respective competent authorities. Our business model is to include HEARTguide in the implant package sold by implant manufacturers to hospitals. According to our estimations, the company will grow to 125 employees by 2024 while generating a positive EBITDA of €10M.

Keywords: transcatheter,heart surgery,planning tool