Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
To deliver the first medical treatment dedicated to patients with haemorrhagic stroke (OP2DRAIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Belgium
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 10535727.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SUSPENDED

The NANOp2lysis platform is a deep-tech technology to protect active enzymes by a reversible precipitation and to produce solid-state nanoparticles. Such particles can then be loaded at high concentration into tailored carrier (with specific targeting / slow delivery characteristics). O2L-001 (derived from NANOp2Lysis) is the first effective and safe treatment to remove intracerebral hematoma and reduce disability and death following acute hemorrhagic stroke (AHS). It has been tailored to be locally injected, after micro-invasive surgery, via a catheter at the core of the hematoma. The in vivo gelation of the product at body temperature allows a local and slow delivery of our new thrombolytic agent, OptPA. The main characteristics of O2L-001 are thus the following: - EASY. simplified model of administration (unique injection) - EFFICIENT. better thrombolytic effect on best translational model (vs gold standard) - SAFE. reduced side effect (bleeding and neurotoxoxicity vs gold standard)

Keywords: unmet medical need,life threatening disease
Innovation in germplasm cryopreservation for improved animal breeding and the conservation of Europe's livestock biodiversity (CryoStore)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Germany,France,Czechia,Netherlands,Portugal,Sweden,Ukraine,Belgium,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2719468.8
EU funding (EUR): 2719468.8
Participants: 23
Project status: SIGNED

CryoStore aims to create a lasting research and education network for a new generation of animal husbandry experts with a broad, multidisciplinary approach to the complexity of modern animal production and the conservation of farm animal biodiversity, taking into account economic, societal and environmental needs. A vibrant and effective animal breeding and production industry is essential to meet Europe´s increasing need for sustainable and secure food production. Farm animal and fish breeding are global, highly competitive and knowledge intensive sectors, and currently European breeding organisations are global leaders. If Europe is to maintain its competitive advantage in these strategically important industries innovative research is needed in those reproductive technologies that underpin efficient and profitable animal production. As such, CryoStore will develop innovative technologies for improved cryopreservation of germplasm (gametes, embryos, germ cells) for use in assisted reproductive procedures, leading to increased reproductive efficiency in Europe´s livestock and aquaculture industries. Technological advances in germplasm cryopreservation will also be of key importance to future initiatives aimed at conserving Europe’s livestock biodiversity, through genetic resource banking. Conserving Europe´s numerous and diverse native breeds, many of which are seriously threatened, will be of crucial importance to future sustainable animal production as genetic biodiversity allows the expression of advantageous traits influencing adaptability to harsh environments or disease resistance. It is likely that selecting for naturally occurring traits will help overcome future difficulties in livestock production wrought by climate change. The intensive training of CryoStore ESRs in a wide range of scientific and transferable skills will greatly enhance their future employability in Europe´s important animal production industries and conservation initiatives.

Keywords: germplasm,cryotechnology,assisted reproductive technologies,animal breeding,aquaculture,conservation biology,genetic resource banking,climate change
The legal foundations for a civic financial system (Civic Finance)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1496084.0
EU funding (EUR): 1496084.0
Participants: 1
Project status: SIGNED

Time is running out for humanity to reduce carbon dioxide (CO2) emissions in order to avoid catastrophic climate change yet the financial system continues to enable unsustainable levels of CO2 emissions in many carbon-intensive sectors, including the fossil fuel industry. Law can help govern this problem but effective legal interventions need to take into account the complexity of the financial system. The overarching objective of the Civic Finance project is to develop a complexity-informed theory of law and finance that can underpin the legal foundations of a civic financial system; in particular, a financial system that refrains from enabling unsustainable levels of CO2 emissions in the fossil fuel industry. To do that, the project will develop a theoretical framework that synthesises institutionalist theories of law and finance with studies of complexity in the financial system. It will then combine doctrinal and socio-legal methodologies to collect empirical data on the legal rules underpinning the European financial system’s continued support of unsustainable levels of CO2 emissions in the fossil fuel industry. To test the effectiveness of these legal rules, the project will develop an agent-based model of the European financial system that will simulate their potential impact on CO2 emissions in the fossil fuel industry. The project will then integrate this simulation data and the empirical data into the theoretical framework to develop a complexity-informed theory of law and finance. Building on institutionalist theories of law and finance, the project argues for the utility of complexity-sensitive methods to study how law shapes complex financial systems. In the longer term, the project will revolutionise how European lawmakers, financial institutions, and civil society organisations use the law to mitigate CO2 emissions enabled by the financial system.

Keywords: complexity,legal thoery of finance,social ecology,agent based modelling
IRB Barcelona International PhD programme: on TARGET for high-impact biomedicine (IRB-TARGET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Germany,Netherlands,Canada,Denmark,Italy,Ireland
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1344000.0
EU funding (EUR): 1344000.0
Participants: 21
Project status: SIGNED

IRB Barcelona (IRB) is an independent, non-profit research centre engaged in basic and applied biomedical science. The IRB-TARGET doctoral programme brings together a network of 21 institutions to implement an impact-oriented training itinerary aligned with IRB’s strategic objective to bring fundamental science closer to applied and clinical research. Through two separate calls, IRB-TARGET will offer 10 four-year fellowships to exceptional doctoral candidates, who can choose and build a strong research project within one of the six interdisciplinary research nodes established at IRB. The selection and recruitment process will build on best practices implemented institution-wide through lessons learned in MSCA-funded COFUND and ITN projects and endorsed by the HRS4R award held by the Institute since 2014. IRB-TARGET aims to consolidate the international recognition of IRB’s PhD Programme by combining the excellence of the research and facilities offered by the institute and its 28 research groups with highly competitive employment conditions and a new holistic training and supervision strategy designed to enhance the employability of fellows and their capacity to respond to the challenges faced by the European Research Area in the coming years. IRB-TARGET will allow IRB to set the foundations for an improved IRB PhD Programme by integrating innovative aspects in the training of a new generation of researchers that go far beyond technical research skills and that include open science principles and research ethics, gender and diversity aspects, data management, entrepreneurship and innovation management, and communication skills aimed at engaging with both scientific audiences and the broader society. IRB-TARGET leverages the expertise of a network of partners that provide training, joint supervision and secondment opportunities, thereby covering the need for interdisciplinary technical skills, international and intersectoral collaboration and networking opportunities

Keywords: doctoral training,personalized career development,biomedicine,translational research,research of excellence,3i dimension,impact oriented training,innovation,societal impact
Hidden in the forest: environmental history and ethnobiology of charcoal burning in Central and Eastern Europe since the19th century (CharcoEnvHist)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Italy
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 2
Project status: SIGNED

Uncovering the details and impacts of different forest uses and their related socio-ecological systems is essential for understanding forest ecosystems. One of these uses is charcoal burning. It was a common type of forest use in Europe from prehistory until the 20th century. Nowadays it is recognized mainly as part of cultural heritage, although it still functions as a raw material source in the production of additional energy . Most studies about charcoal production focus on the history and vegetation impact before the 19th century in Western Europe and prioritize the male perspective of this forest use. The aim of this project is to examine the environmental history and vegetation of active and abandoned charcoal kiln sites, emphasising the role of women and children in this forest use and the traditional ecological knowledge of charcoal burners since the 19th century in Central and Eastern Europe. The project will apply ecological, ethnobiological and historical data collection methods in three work packages: WP1: Literature review, WP2: Field work, WP3: Archival Research. The project will provide novel data about non-timber forest uses and highlight the role of women and children and their active role in charcoal burning. Research into the interaction of so-far neglected groups with nature will support the preservation of the biocultural heritage of European forested landscapes and provide new insights for energy production and landscape management. To achieve these goals, I will use the facilities of the host institute (HI), the Institute of Botany of the Czech Academy of Sciences and the Secondment place, the University of Turin. The expertise of my supervisor at the host institute, Dr. Péter Szabó, and mentor of the SP, Dr. Giacomo Bonan, in interdisciplinary research of forest history will provide me with an excellent background that will broaden my horizons and contribute to my further development in academia.

Keywords: historical ecology,forest history,vegetation,biocultural heritage,industrial history,renewable energy,children,women,environmental humanities,ethnobiology,social ecological systems
Development of a Novel Cell-Derived, Cell-Free Therapeutic for Treating Fibrotic Diseases, with an Initial Focus on Idiopathic Pulmonary Fibrosis (REMEDY CELL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Founded in 2020, Remedy Cell is a clinical-stage biopharmaceutical company advancing novel cell-derived, cell-free therapies for fibrotic diseases—conditions with clear unmet medical needs. Remedy Cell's innovative Activated Remedy Cell Secretome (ARcS) platform offers a multi-targeted approach to treat fibrosis and regenerate tissues across a range of indications, including idiopathic pulmonary fibrosis (IPF), a devastating lung disease with no curative options. Unlike traditional single-target therapies, ARcS address the multifactorial nature of fibrosis, leveraging cell-free secretomes characterized with proteins that degrade extracellular matrix (ECM) components, modulate inflammation, and promote tissue regeneration. Remedy Cell's lead product, RC-0315, has demonstrated unprecedented efficacy in preclinical IPF models, reversing fibrosis, restoring lung function, and remodeling diseased tissue. These promising outcomes are supported by human ex vivo studies, highlighting RC-0315's potential to transform IPF care. With IPF affecting over 3 million people globally and a growing treatment market projected to reach $6.2 billion by 2030, RC-0315 addresses an urgent need for more effective therapies. Current treatments like Nintedanib and Pirfenidone only slow disease progression and carry significant side effects, leaving a critical gap for a multifunctional, disease-modifying solution. Remedy Cell's team comprises multidisciplinary and seasoned professionals, holds strong patents, and has raised €9M in private investments. The company aims to initiate first-in-human Phase Ib trials for RC-0315 in 2025, with a long-term vision of expanding ARcS applications to other fibrotic diseases and significantly increasing patients' quality and expectancy of life. By advancing RC-0315 and scaling its ARcS platform, Remedy Cell is poised to redefine the care landscape for fibrotic diseases, delivering life-changing therapies and setting new standards in regenerative medicine.

Keywords: clinical medicine,therapeutics,advance therapeutics,fibrosis,respiratory,stem cell,complex diseases,bioprocessing technologies
Revolutionary solution to unlock concrete-to-concrete circularity (C2CA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

C2CA, a spin-off from TU Delft, is pioneering a revolutionary solution to transform the construction industry by upcycling waste concrete. Cement contributes 8% of global CO2 emissions but is crucial for our infrastructure and quality of life. These emissions are hard to reduce due to cement's commoditization, the abundance of low-cost limestone, ease of use, versatility, and high performance. To mitigate these emissions, the C2CA solution is to upcycle waste concrete – available worldwide at zero or negative cost – into a low-carbon cement substitute. C2CA has developed a unique and defensible process: the only company with the complete process know-how to upcycle waste concrete into new, high-quality materials and particularly a low carbon highly reactive cementitious binder. Other companies "downcycle" concrete waste into low-quality aggregates, Whereas C2CA produces a high-quality low-carbon material to replace cement in concrete, offering both environmental and commercial value. The C2CA low-carbon cement competes on cost and quality with traditional alternatives such as fly-ash and slag, which are being phased, as well as emerging materials like calcined clay or mine tailings, which are energy-intensive or costly to transport. By 2024, C2CA has developed its core machines on an industrial scale, and processed about 1000 tons of waste concrete. Our materials have been used in a dozen pilot projects, receiving technical and commercial validation from customers. The next major milestone is to build a large commercial factory to demonstrate the full process, validate its economic model, and support future financing needs. In addition, C2CA must invest in R&D to enhance its technology with AI sensors for input materials and adaptive process controls to ensure consistent, high-quality output despite variable input quality. C2CA will develop a digital twin to simulate and optimize its process for all world regions.

Keywords: circular concrete,waste concrete upcycling,co2 emission reduction,green cement,low carbon cement,decarbonization
Bridging Research Institutions to Catalyze Generative AI Adoption by the Health Sector in the Widening Countries (ChatMED)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: North Macedonia,Slovenia,Serbia,Austria
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1329875.0
EU funding (EUR): 1329875.0
Participants: 4
Project status: SIGNED

In a bid to harness cutting-edge AI advancements, Slovenia and Austria, AI research frontrunners, united with two Widening countries, North Macedonia and Serbia, to propose a transformative mission to bridge the knowledge gap, and to propagate Generative AI expertise with the goal to meld AI into pragmatic medical contexts. Together, they are laying a foundation for a cross-border collaboration methodology that through training missions, workshops, seminars, and collaborative deep dive research would enrich minds and redefine medical practices. The collective effort, wisdom, and adaptability as a guiding principle, will dive into the core of the Large Language Models to explore the capability of transforming complex medical knowledge into valuable medical diagnoses and treatment recommendations. Through simulated real-world medical challenges, the team will resonate in the practicality of Generative AI and the specific requirements that such AI-based software would require to be implemented practically in the hospitals. Through this project the partners from the Widening countries will master coordination skills, while the research on Generative AI will alter the medical landscapes.

Keywords: generative ai,large language models,medicine,healthcare,knowledge transfer,cross border collaboration
Nonlinear Excitation of Ideal Anapoles (NExIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Anapoles are nonradiating states of light, in which optical fields are trapped by destructive interference of outgoing radiation. They have recently attracted significant interest due to their potential in resonant nanoscale light confinement, which could be used in lasers, sensors, quantum computers and other areas of light-based research and technology. However, ideal anapoles have never been experimentally achieved, because making them perfectly decoupled from external radiation would prevent their excitation and observation. The proposed project will resolve the above issues. Advanced theoretical modeling tools will be used to design the ideal anapoles that can be excited through second-harmonic generation. In this process, the incident light would illuminate the anapolar nanoresonators and nonlinearly induce local optical fields matching the anapole's excitation at twice the incident light frequency. Second-harmonic optical fields may form configurations that can not be induced through linear interactions with external optical fields, hence allowing these local fields to be fully decoupled from external radiation. These local nonradiating fields will then induce photoluminescence at optical wavelengths detuned from the anapole's resonance. Detecting this photoluminescence will enable probing the anapole excitation. To demonstrate this concept in experiments, resonant photonic samples will be fabricated in the silicon nitride (Si3N4) material platform, integrated with molibdenium disulfide (MoS2) monolayers which can simultaneously support efficient second-harmonic generation and photoluminescence. The samples will be excited by time-controlled ultrashort laser pulses, enabling investigation of the temporal dynamics of the anapole's local optical fields and retrieving their Q factors. Demonstration of the ideal anapoles is an ambitious and challenging goal with breakthrough potential for the research on confined states of light and their possible applications.

Keywords: ultrafast optics,optical anapoles,second harmonic generation,interferometry,nanophotonics,photonic nanostructures,optical nanocavities,optical multipoles,nonlinear optics