Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving quality and safety in the hospital: The link between organisational culture, burnout, and quality of care (ORCAB)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Greece,Türkiye,Romania,Croatia,United Kingdom,Ireland,Portugal,Bulgaria,North Macedonia
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-11-01
End date: 2014-04-30
Duration (months): 54.0
Total project cost (EUR): 2480640.0
EU funding (EUR): 1910480.0
Participants: 10
Project status: CLOSED

To date, relatively little evidence has been published as to what represents an effective and efficient way to improve quality of care and safety in hospitals. This vacuum in the research means there is a significant opportunity to design quality of care and safety interventions in collaboration with the relevant stakeholders, which address the relevant organisational and individual factors in a hospital setting. The aim of the present project will be; to benchmark the organisational and individual factors that impact on quality of care and patient safety, and design bottom-up interventions that both increase quality of care and physician well being. In specific the project has the following objectives: (1) To profile the specific factors of hospital-organisational culture that increase burnout among physicians, and therefore decrease quality of care, (2) To monitor burnout and its associations to quality of hospital care among physicians, (3) To identify appropriate bottom-up solutions to the problems of organisational culture and physician burnout, and its impact upon patient safety and quality of care, and (4) To develop a network for hospital managers and associated stakeholders for the communication of interventions aimed improving quality of care in hospitals. The work plan of the proposed project will consists of 3 phases: The first phase will be a preparatory one where the foundations for the following phases in terms of organisational and informational background will be outlined The second phase will assess the organisational culture, burnout and quality of care. A multi-centre survey will be conducted in physicians and patients from selected hospital-sites from South and SE Europe. This third phase will address how to improving quality of care using action research. The phase will use action research to involve health professionals and members of management boards in each hospital site to develop their own interventions for improving quality of care.

Keywords: organisational culture,burnout,quality of care
Luminescent polymers for in vivo imaging of amyloid signatures (LUPAS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Sweden,France,Germany,Norway,Switzerland,Germany,Sweden,Israel
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-11-01
End date: 2012-12-31
Duration (months): 38.0
Total project cost (EUR): 6475643.2
EU funding (EUR): 4978094.8
Participants: 8
Project status: CLOSED

In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative methodology for studying neurodegenerative diseases. The objectives include the development of novel imaging agents that can be utilized for biomedical research, diagnosis, monitoring and prognosis, and for support and guidance of therapeutic interventions for Alzheimer’s disease and prion diseases. The consortium is composed of expert groups in experimental optics, polymer synthesis, magnetic resonance imaging (MRI), synthesis of functionalized magnetic nanoparticles, amyloid structure, AD mouse models, clinical AD, and prion diseases. At the same time this project establishes strategic links between mainly SME based Industries, expert researchers at universities and principal users in terms of hospitals. The project consortium will develop and share an efficient plan for dissemination and exploitation of the project results.
The targeted development of a new generation Vaccine for Schistosomiasis (THESCHISTOVAC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Netherlands,France,United Kingdom,Denmark,Germany,United Kingdom,Ghana,Uganda,Kenya,France,Gabon,Germany
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-02-01
End date: 2014-07-31
Duration (months): 54.0
Total project cost (EUR): 5161126.37
EU funding (EUR): 3799975.0
Participants: 13
Project status: CLOSED

The aim of this project is to develop a new generation vaccine for schistosomiasis. The vaccine will be based on exposed proteins and/or glycans of the vulnerable skin stage schistosomula, making it safe and effective. The life stage-specific vaccine target selection strategy is based on state-of-the-art schistosomal transcriptomics and glycomics technologies and data, and unique serum and sample libraries from endemic areas will be the key to identifying protective immune responses and effective targets. Preclinical in vitro (cellular and whole parasite) and in vivo (rat model) testing of protective antigens with respect to cellular responses and effective parasite killing are part of the development pipeline. Analysis of human T- and B-cell responsiveness is an integral part of the approach. A unique SME-led approach to potentiate the effect of immunisation by use of engineering engineered antibodies will also be part of the project. The project involves strong participation of researchers from four schistosomiasis-endemic countries, and several European groups all with a long history of successful collaboration.

Keywords: schistosomiasis,helminth,vaccine,endemic population,genomics,glycomics,t-cell,b-cell immunology,human cohorts,phd training,in vitro,in vivo models,protection enhancement
Quality and costs of primary care in Europe (QUALICOPC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Netherlands,Italy,Germany,Belgium,Slovenia
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 2637052.2
EU funding (EUR): 2198877.0
Participants: 6
Project status: CLOSED

The QUALICOPC study aims to comprehensively evaluate primary care systems in Europe against criteria of quality, equity and costs. The study will provide an answer to the question what strong primary care systems entail and which effects strong primary care systems have on the performance of overall health care systems. The study will collect data in 32 countries in Europe by means of two surveys: one among general practitioners and another among users of patients in primary care. In addition, the study will use external data sources, such as: the System of Health Accounts (developed by Eurostat and OECD); the Health Care Quality Indicators Project (by OECD) and the PHAMEU data base (a product of a EU DG Sanco funded European project). The consortium for QUALICOPC represents all the expertise needed for this ambitious study, including links to the external data sources. The networks of the consortium members safeguard an effective dissemination of the study results to the research community, policy makers and other stakeholders in the European health sector. He dissemination strategy includes: the publication of articles in scientific and professional journals; publication of news and other project related information at the website; production of a book and policy briefs; presentations at policy meetings and conferences; and the organisation of a final conference. By its innovative design, in which different data sources are combined for comprehensive analyses, QUALICOPC will advance the state of the art in primary care research and contribute to the body of knowledge. This is both a scientific achievement and a contribution to evidence based health policy development in Europe.

Keywords: primary care,quality of care,costs of health care,models of organisation,equity,patient satisfaction.
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,United Kingdom,United Kingdom,Germany,Germany,Germany,Denmark,Sweden,France,Belgium,Finland,United Kingdom,Sweden
Call:  (FP7-HEALTH-2009-two-stage, 2009)
Start date: 2010-07-01
End date: 2014-12-31
Duration (months): 54.0
Total project cost (EUR): 14327877.73
EU funding (EUR): 10739837.0
Participants: 18
Project status: CLOSED

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic modeling, with the perspective to generate a blueprint for discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease.

Keywords: synapse,dynamic modeling,interactome,physiology,brain,disease
Quantum Dot-Based Highly Sensitive Immunoassays for Multiplexed Diagnostics of Alzheimer's Disease (NANOGNOSTICS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Germany,France,Germany,Germany,Israel,Germany,Finland,United Kingdom,France
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-10-01
End date: 2013-03-31
Duration (months): 42.0
Total project cost (EUR): 5281158.66
EU funding (EUR): 4037064.0
Participants: 10
Project status: CLOSED

6.1 million people currently live with a form of dementia in the European Union with an addition of 1.4 million new cases every year. Combination of psychological testing, brain-imaging and exclusion of other neurological disorders makes the diagnosis of Alzheimer’s disease complicated and time consuming (taking up to 20 months). A rapid, sensitive and specific immunoassay for protein markers inside blood would largely improve early diagnosis and lead to a better treatment of dementia. Homogeneous assays based on FRET from one dye labeled specific antibody (AB1) to another (AB2) within an “AB1-biomarker-AB2” immune complex are an ideal basis to meet these diagnostic requirements. As the detection of several protein markers is obligatory for a highly sensitive and specific diagnosis an optical multiplexing approach with dyes of different colors is a smart solution. Semiconductor quantum dots (QDs) are the ideal candidates due to their size-dependent absorption and emission wavelengths. Moreover, they possess unique photophysical properties that overcome conventional fluorescence dyes. In combination with lanthanide complexes (LCs), that display long luminescence lifetimes and well separated emission bands, QDs render a powerful multiplexing tool for highly sensitive diagnostics even for large immune complexes. FRET applications using QDs are to date restricted to academic research and a profound understanding of QD-based FRET is not available. For a comprehensive analysis the use of LCs is mandatory, because they are the only known donors for efficient FRET to QD acceptors. NANOGNOSTICS strives for a profound understanding of QD-based FRET, the synthetic creation of highly efficient QD immune sensors for detection of several Alzheimer-specific protein markers and the development of a modular high-throughput-screening immuno analyzer for the integration of QD-based multiplexing immunoassays into early diagnosis for improved patient outcome in dementia therapy.

Keywords: diagnostics,in-vitro,multiplexing,immunoassay,alzheimer,dementia,fret,quantum dots,nano,lanthanides,fluorescence,spectroscopy,theragnostics
Integrated approach to IMprove the supply chain for COntainer transport and integrated SECurity simultaneously (IMCOSEC)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Coordination and support actions
Countries involved: Germany,France,United Kingdom,Italy,Germany,Germany,Belgium
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-04-01
End date: 2011-03-31
Duration (months): 12.0
Total project cost (EUR): 1142591.0
EU funding (EUR): 930718.0
Participants: 9
Project status: CLOSED

There are two contradicting trends in global transport (which are valid also for the segment of containers and other ILUs ) that have to be aligned in the most efficient way – assuring free trade and assuring transport security. Thus, it is essential that private end-users and public end-users work together on the improvement of supply chain security to ensure public safety and security as well as the efficient flow of goods. IMCOSEC – “Integrated approach to IMprove the supply chain for COntainer transport and integrated SECurity simultaneously” is a risk based approach to identify and characterize the security gaps, preventive measures will be discussed and a guiding concept for demonstrations in phase II will be defined, with the aim to make the supply chains in their totality more secure without major negative impacts on their performance and without creating unjustifiable additional cost. An optimal solution will be creating win-win situations between industry and administration and will not imply as much security as possible, but as much security as needed and acceptable. Acceptance is one of the most important issues on the sustainability of the strategic roadmap to be developed. Therefore the consortium results will be discussed, reflected and validated by a series of international workshops with stakeholders and the projects Advisory Board involving additional stakeholders from private end-users and public end-users. This will mainly contribute to European wide awareness and shall ensure that the target processes defined and technologies assembled will be applicable in the real world business. The partners are well experienced in the sector – either from its logistics or from its security angle. The Consortium includes international associations, security consultants and research institutions, experts from the maritime and inland/combined transport, as well as an operator of a container security platform.

Keywords: security,supply chain,container,intermodal,integrated,transport
Millimetre-wave Integrated Diode and Amplifier Sources (MIDAS)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: United Kingdom,France,Spain,Germany
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 1309593.96
EU funding (EUR): 940000.0
Participants: 4
Project status: CLOSED

The MIDAS project will redress the technology imbalance between the EU and the US in a most significant area of European technology non-dependence, affecting the scientific and commercial exploitation of the sub-millimetre region of the electro-magnetic spectrum. Within MIDAS, critical Schottky varactor diodes and the simulation tools for fabricating and designing state-of-the-art sub-millimetre wave components and sources will be developed. Using these, a demonstrator terahertz source will be fabricated, with the aim of generating levels of RF power previously unavailable within Europe. A small team of complementary expertise has been chosen to undertake the programme, combining world class researchers in the respective fields of circuit simulation, design and fabrication, with the leading SME in Europe supplying terahertz components to the space and commercial arenas. European amplifier technology, combined with optimised Schottky varactors fabricated on diamond substrates, will demonstrate a novel, generic, terahertz source technology, enabling planned sub-millimetre wave space science and Earth observation instrumentation to use wholly European technology. The ability for Europe to exploit the terahertz spectrum, which is recognised to be of key scientific and commercial importance, will be significantly enhanced.

Keywords: millimetre-wave,schottky,high-frequency
A holistic approach towards the development of the first responder of the future (E-SPONDER)

Framework: FP7 — Cooperation
Programme: Security
Destination: Restoring security and safety in case of crisis
Action type: Collaborative project
Countries involved: Greece,Italy,Netherlands,France,Switzerland,Germany,Germany,Taiwan, Province of China,France,Spain,Germany,Spain,Poland
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-07-01
End date: 2014-12-31
Duration (months): 54.0
Total project cost (EUR): 12542904.3
EU funding (EUR): 8790044.0
Participants: 17
Project status: CLOSED

The E-SPONDER is a suite of real-time data-centric technologies which will provide actionable information and communication support to first responders that act during abnormal events (crises) occurring in critical infrastructures. This information will enable improved control and management, resulting in real time synchronization between forces on the ground (police, rescue, firefighters) and out-of-theater command and control centers (CC). The approach guiding the E-SPONDER project is based on the fusion of variable forms of field-derived data within a central system which will then provide information analysis and decision support applications at designated CC locations in order to provide in situ support to first responders that operate in Critical Infrastructures. Statistics show that efficient emergency system can reduce accident losses to 6%, compared with situations without emergency system . As a result, an efficient emergency system is a key to cope with all kinds of sudden events and improve safety of cities and countries. To do this, E-SPONDER will achieve the following objectives: i) Improvement of front end data collection technologies installed both on portable and fixed platforms, providing a flexible yet comprehensive coverage of the affected area; ii) this data will then be fused and analyzed to provide real-time decision support; iii) E-SPONDER will make these resources readily available to commanders through the use of easily accessible web-portals but lastly and most important it will provide significant support based on Information and Communication Technologies to the First Responders. Thus, E-SPONDER will minimize the uncertainty that characterizes crisis events, thereby limiting their scope. Once E-SPONDER elements are ready for deployment they will be integrated and extensively field tested.

Keywords: first responders,emergency,crisis management,logistics of operations,training of units,cbrn,natural disasters
Towards Human Exploration of Space: a EUropean Strategy (THESEUS)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Coordination and support actions
Countries involved: France,France,Germany,France,Belgium,United Kingdom
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-01-01
End date: 2012-03-31
Duration (months): 27.0
Total project cost (EUR): 944109.67
EU funding (EUR): 806069.0
Participants: 6
Project status: CLOSED

Space missions in Earth orbit have demonstrated that men can survive and work in space for long durations. However, there are pending technological, medical and psychological issues to be solved before adventuring in longer duration space missions. Furthermore technological breakthroughs, e.g. in life support systems and recycling technologies are required to reduce the costs of these expeditions. Solving these issues will need scientific and technological breakthroughs of interest for clinical and industrial applications and also allow identifying the relevance of these questions to health issues on Earth. Despite existing ESA or NASA studies or roadmaps Europe still has no scientific and industrial roadmap. The THESEUS objective is to develop an integrated life sciences research roadmap enabling European human space exploration in synergy with ESA, taking advantage of the European expertise and identifying the potential of non space applications and dual research and development. It will (1) identify disciplinary research priorities; (2) focus on fields with high terrestrial application potential; (3) build a European network as the core of this strategy. This will be achieved by setting-up and coordinating 15 Expert Groups of European and international experts, ensuring that complementary expertises are gathered and that experts coming from non European countries and from the industrial sectors are included. They will be asked to develop their activities and recommendations based on the scenario proposed by ESA Space Exploration Architecture (human presence in Low Earth Orbit, return to the Moon and human exploration of Mars). The work plan is structured to develop a survey of the state of the art, an improved focus on the relevance of the relevant research for current and upcoming health challenges on Earth and otential bio-medical application, a detailed set of disciplinary priorities and an integrated roadmap providing strategic orientations for research.

Keywords: human space exploration,long-duration spaceflight,life support systems