Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SOCLE - SOCial SeLEction in cultivated plants (SOCLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

As early shown with social insects, natural selection can maximize group performance by favouring the evolution of altruistic phenotypes. Such social selection has been shown to occur in a wide range of taxon, mainly in animals and microorganisms. Conversely, we have a very poor knowledge of social interactions in plants, mainly because the study of plant-plant interactions has largely remained disconnected from social evolution theory. For example, we don’t know which plant traits have social effects, and we don't know to what extent plant group performance can be affected by social effects. Better understanding social interactions in plants could open new opportunities for plant breeding. Indeed, it has long been suggested that crop yields could be increased by selecting more cooperative varieties. Moreover, advances in animal breeding based on social evolution have already shown convincing results. The aim of this project is thus to better understand social interaction in plants, using crops as a model system. Based on a competition experiment, I will use three approaches: a trait-blind approach, a trait-based approach, and a genomic approach. In the first approach, I will use the indirect genetic effects (IGE) framework to quantify the amount of heritable variation on crop yield that is due to social interactions, and compare it to the non-social heritable variation. With the second approach, I will test the social effects of a set of ecologically and agronomically important traits in order to identify those that contribute most to social interactions. Finally, I will use a genomic approach to look for genomic regions involved in social effects. Conducted in collaboration with plant breeders and leading scientists in the field of social evolution, this multi-disciplinary project will address fundamental research questions related to plant-plant interactions and their evolution, and pave the way for innovative agronomic solutions based on crop cooperation.

Keywords: social evolution,crops,cooperation,indirect genetic effects,intraspecific interactions,plant breeding
TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: South Africa,Germany,Spain,Ireland,Australia,Germany,Germany,Germany,Spain,Italy,Italy,Switzerland,Switzerland,Switzerland,Switzerland,Belgium,Belgium,Korea, Republic of,Belgium,France,France,France,France,Netherlands,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Vaccine development for poverty-related and neglected infectious diseases: tuberculosis (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2019-06-30
Duration (months): 54.0
Total project cost (EUR): 25056507.33
EU funding (EUR): 18200000.0
Participants: 49
Project status: CLOSED

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal. TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).

Keywords: tuberculosis,discovery,preclinical and early clinical development,correlates of protection,portfolio management
Using TUnnel Magneto Resistance Technology for MAgnetic POSition Measurement TUMAPOS (TUMAPOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2015, 2015)
Start date: 2015-11-01
End date: 2018-02-28
Duration (months): 28.0
Total project cost (EUR): 1473400.0
EU funding (EUR): 1031380.0
Participants: 1
Project status: CLOSED

BOGEN Electronic GmbH, a German company with a 60 year history, is recognized as a leading magnetic production specialist for information recording and measurement. The aim of this project is to improve BOGEN's position in the magnetic measurement field and increase turnover, create new jobs and increase profit. The project objective is to bring a new magnetic measurement solution to market that will extend the applicability of magnetic measurement in two directions: - Higher accuracy, especially to compete with optical measurement systems with a cheaper magnetic solution - Enter a new business area, where customers request bigger reading distances between scale and sensor The development of the new measurement solution requires three parts: - Improve the TMR elements reading magnetic scales to read the scales at a distance of 4 pole pitches, - Improve the inductive writing methodology to write pole pitches smaller than 25 microns, - Replace the AMR elements in the current sensing heads with the TMR elements and finalize the product With the results of the project, BOGEN can increase the reading distance to for several industries, where the accuracy is secondary to the reading distance. With the increased reading distance, finer pole pitches can be read at a shorter distance. This will provide access to many measuring tasks that can be measured only with optical solutions today and open a market potential of € 600 million. The combination – using TMR and smaller scale increments - will lead to magnetic measurement solutions with higher accuracy at lower cost. During the feasibility study, a TMR based solution was developed and successfully tested. BOGEN has a lot of experience in sensing head design and magnetic scale production, with a patent covering the most effective method to produce the smallest scale increments. The project work is organized to bring the solution from technology readiness level 6 to 9.

Keywords: position measurement,motion control
Epigenetics of Canine Domestication from the Upper Paleolithic onwards (EpiCDomestic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The domestication of plants and animals is increasingly being seen as a distinct evolutionary process. In cases such as that of the domestic dog, this process is shaped by practical requirements often intertwined with environmental stress. However, a convincing reconciliation of the rapid phenotypic alteration observed in early canine domesticates and the associated molecular evolution rates is yet to be modelled. The hypothesis of this project is that epigenetic activity, being increasingly seen as an evolutionary driver and known to be affected by environmental stress, is a central process to the evolution / domestication paradigm. Archaeological samples of wolves and contemporary early dog domesticates provide an ideal dataset with which to explore this hypothesis. A large collection of such remains from different environs (Siberia, Greenland and Denmark), spanning a large time-scale from the Upper Paleolithic around 30,000 years before present, to the second millennium CE, present the opportunity to explore this hypothesis and identify molecular variation where domestication has taken different regional tracts. A combination of ancient DNA, ancient RNA, and advanced bioinformatic approaches will allow us to see not only the paleogenomic state, but how it fluctuates and evolves according to its environment. Paleogenomic approaches to epigenetics are at the forefront of evolutionary biology and allow real-time snapshots of such evolutionary process to be observed. The combined expertise of the applicant and host institution in paleogenomic research, the state-of-the-art methodology proposed, and the global importance of dogs to humans will result in significant and high-impact output, beneficial to all concerned.

Keywords: ancient dna,ancient rna,evolution,domestication,archaeology,holocene,pleistocene,paleolithic,epigenetics,bioinformatics,canines,dogs,wolves
Better Addiction Medicine Education for Doctors (BEAMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2021-08-24
Duration (months): 36.0
Total project cost (EUR): 251555.4
EU funding (EUR): 251555.4
Participants: 2
Project status: CLOSED

Drug and alcohol addiction cause a significant social and economic burden globally. Adequate diagnosis and treatment by general practitioners fails, in part due to a lack of knowledge and accredited training in addiction medicine. In Ireland, the training of general practitioners in identifying and treating addiction is lacking. Internationally, a number of initiatives to address this challenge have emerged, including a specialised training programme in Canada (www.addictionmedicinefellowship.org). To build on these initiatives, the goal of this project is to establish the feasibility and acceptability of training primary care practitioners in addiction medicine, and, in particular, how international models of addiction medicine training might inform the future development of general practice education in Ireland. Specifically, the proposed fellowship seeks to increase incorporation of new understandings about addictive disorders from multiple disciplines into undergraduate and postgraduate medical curricula. The disciplines include public health, general practice, psychiatry and health services research. The programme will involve three phases: 1. the outgoing phase will study the Canadian addiction medicine fellowship and its rigorous evaluation strategy: a Novel Evaluation of the Fellowship in Addiction Research (NEAR). 2. The transition phase will consult the experts and assess educational needs in both systems. 3. The re-entry phase will use the knowledge from Canada and educational needs assessments to develop and pilot-test a multidisciplinary translational environment focused on increasing knowledge of the prevention and treatment of drug and alcohol addiction by general practitioners. This proposal improves addiction education for doctors and responds directly to the ERA priorities “Excellent Science, Health, Demographic Change and Wellbeing”, specifically “improve ability to monitor health and to prevent, detect, treat and manage disease”.

Keywords: primary care,addiction,teaching and learning,health services,health care research
A cartridge based flow chemistry machine for the automated synthesis of N-heterocycles for drug discovery (HETSPRESSO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-11-01
End date: 2018-04-30
Duration (months): 18.0
Total project cost (EUR): 149040.0
EU funding (EUR): 149040.0
Participants: 1
Project status: CLOSED

Saturated N-heterocycles are an important class of compounds and are attractive as scaffolds in the development of new pharmaceuticals. As part of ERC supported research, we identified a new class of chemical reagents – “SnAP Reagents” – that alleviate previous synthetic challenges. These SnAP reagents enable the synthesis of more drug-like saturated N-heterocycles, including some of the most sought after, but most difficult to prepare scaffolds. They have been successfully commercialized and are in high demand. This high consumer demand, which is indicative of the interest in these products, is despite the disadvantages of this methodology: use of toxic materials, long reaction times, and relatively complicated reaction setups and workups. Furthermore, the sales of the reagents – while successful – have low margins and there are few opportunities for IP protection. We have therefore begun development of an innovative, cartridge-based, fully automated, stand-alone machine for conducting SnAP chemistry in a safe, rapid, and convenient manner. This approach provides a clear roadmap for a sustainable, successful Startup Entity by the development and sale of proprietary machines and disposable cartridges. The ERC PoC funding will be used to assemble sufficient prototype machines and develop disposable cartridges for initial sales and marketing efforts. The successful assembly of a working prototype will provide the basis for the sale of first generation machines and a revenue stream for establishing a sustainable business. We have already identified interested parties who will purchase the first-generation instruments and provide valuable feedback for improving and optimizing their operation. In the longer-term, it is expected that sales of the disposable reagent cartridges and development of new machines that follow the same principles will emerge as the main activities of the start up company. We will also translate the technology and IP to other chemistries.

Keywords: organic synthesis,drug discovery,heterocycles,flow chemistry,reagents
Implemented MOnitoring system for structural DIsplacement (I.MODI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: SME Instrument (H2020-SMEINST-2-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 791250.0
EU funding (EUR): 553875.0
Participants: 1
Project status: CLOSED

I.MODI aims at exploiting business opportunity generated by the increasing need to have a systematic monitoring system able to control stability of buildings and civil infrastructures. It focuses on the exploitation of EO data to create an added value service where the integration between EO observation (Sentinel 1/Copernicus, COSMO-SkyMed and ESA archive SAR data from ERS-1/2 and Envisat) and ground-based technologies represents the core of the system and becomes easily accessible from users. I.MODI is expected to overcome the need to develop a specific SAR knowledge (the most significant “cultural” barrier to the adoption of the techniques), leverage scientifically validated practices based consolidated monitoring methodologies to be further evolved into innovative operational prototypes. By exploiting the EO and ground based dataset, 3D numerical maps, and GIS spatial analysis, the I.MODI technology will support the monitoring activity and contribute to damage assessment analysis through the calibration on advanced numerical modelling. The I.MODI project will: i. define standards for the structural monitoring, damage assessment and infrastructure impact modelling using advanced EO services & products; ii. test, prototype and industrialize an innovative range of monitoring services also based on the outcome of the feasibility project carried out within the ESA/BIC Lazio initiative (already funded and completed), according to user requirements defined by primary European infrastructure managers; iii. disseminate the project results through a multichannel communication strategy by organizing workshops involving key stakeholders and service users, web based campaigns, and more traditional communication (e.g. papers and press clippings); iv. define an appropriate business model to guarantee the long-term sustainability of the new operational monitoring system; v. develop a commercialization/business plan targeted at key user segments.

Keywords: dinsar data,displacement monitoring,integration in situ eo data,structural damage assessment
European Vaccine Research and Development Infrastructure (TRANSVAC2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Italy,Germany,Switzerland,Switzerland,France,France,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom,Denmark,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-05-01
End date: 2023-04-30
Duration (months): 72.0
Total project cost (EUR): 14556732.34
EU funding (EUR): 14556732.33
Participants: 31
Project status: SIGNED

TRANSVAC2 is the follow-up project to its successful predecessor project TRANSVAC, the European Network of Vaccine Research and Development funded under FP7. The TRANSVAC2 consortium comprises a comprehensive collection of leading European institutions that propose to further advance with the previous initiative towards the establishment of a fully operational and sustainable European vaccine R&D infrastructure. TRANSVAC2 will support innovation for both prophylactic and therapeutic vaccine development based on a disease-overarching and one-health approach, thereby optimising the knowledge and expertise gained during the development of both human and animal vaccines. This will be achieved by bridging the translational gap in biomedical research, and by supporting cooperation between public vaccine R&D institutions of excellence, related initiatives and networks in Europe, and industrial partners. TRANSVAC2 will complement and integrate with existing European research infrastructures in both the public and private sectors. TRANSVAC2 will function as leverage and innovation catalyst between all stakeholders involved in vaccine R&D in Europe and -by providing integrated and overarching vaccine R&D services- will contribute to the development of effective products to address European and global health challenges, to controlling the burden and spread of infectious diseases, and reinforce the economic assets represented by vaccine developers in Europe. The impact of TRANSVAC2 will be maximised by two external advisory bodies. An independent Scientific & Ethics Advisory Committee will provide recommendations surrounding scientific-technical and ethical issues, whereas the coordination of TRANSVAC2 with other related initiatives and the further promotion of the long-term stability of a European vaccine R&D infrastructure will be supported by a Board of Stakeholders comprising representatives of policy and decision makers, industry associations and European infrastructures.

Keywords: vaccine,vaccinology,randd,prophylactic,therapeutic,human,veterinary,infrastructure
Functional Links in Avian, Microbial, Macrophyte, and INvertebrate Greenhouse Gas Output Stimulation (FLAMMINGGOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-09-13
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Mounting evidence suggests that aquatic invertebrate activity can enhance wetland sediment greenhouse gas (GHG) flux. However, waterbirds have been shown to reduce densities of aquatic invertebrates, which could potentially moderate GHG flux. Alternatively, carbon (C), nitrogen (N), and phosphorus (P) subsidies in waterbird guano may stimulate microbial activity. These bottom-up forces may stimulate GHG flux and dampen the top-down effects of predation. For the proposed study, a network of long-term waterbird exclosure plots will be established within the Doñana Natural Space in southern Spain. 144 experimental plots will manipulate the presence of waterbirds in vegetated and unvegetated wetlands, and will create a gradient in C, N, and P (guano) inputs, with the following six treatments: X = no birds present, W = waterfowl present, and F = flamingos + waterfowl present. Controlled laboratory and outdoor mesocosm studies will further examine the interacting stimulatory effects of waterbird guano and benthic invertebrates on GHG flux. Responses compared among treatments will include benthic and water-air fluxes of nitrous oxide, methane, and carbon dioxide, invertebrate densities and biomass, and abundances of microbial genes that are functionally linked to GHG flux (e.g. nirK, nirS, nosZ). Environmental data will be incorporated into predictive GHG flux models, including benthic invertebrate density and biomass; macrophyte density and biomass; water and sediment C, N and P content; and temperature and dissolved oxygen. By manipulating waterbird and invertebrate densities, this will be the first manipulative field study to simultaneously test the hypotheses that benthic invertebrates stimulate GHG emissions, and that higher trophic levels (waterbirds) exert both top-down and bottom-up influence on this process. This represents a new and potentially transformative line of inquiry into the roles of multiple trophic levels in regulating global wetland GHG flux.

Keywords: waterbird,trophic cascade,greenhouse gas emission,flux,wetland,top down,bottom up,macrophyte,invertebrate,flamingo,waterfowl,polychaeta,oligochaeta,chironomidae,methane,nitrous oxide