Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Island plant radiations as models to understand adaptive evolution and predict responses to future climate change: an integrative and multiscale approach in Asteraceae (AsterAdapt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-02
End date: 2028-03-01
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 2
Project status: SIGNED

Biodiversity is disappearing at an unprecedented high pace in human history, with climate change being one of the main drivers of this loss. However, there are still major gaps in our understanding of how species evolve and how they may respond to climate change, making it difficult to take effective conservation action to halt this biodiversity loss. Oceanic islands - those that have never been connected to continental landmasses - are considered biodiversity hotspots, harbouring a unique biota as a result of explosive diversification events in which multiple species arise from a single ancestor (radiations). These radiations usually occur within a short period of time due to the rapid adaptation of species to new island environments (adaptive radiations). In the AsterAdapt project, two island plant radiations will be studied to learn about the adaptation process behind high species diversification and to use this knowledge to predict the impact of climate change on oceanic island plants. Specifically, it aims to assess the extent to which the specific environmental conditions of the species have determined the evolution of species traits and their genetic differentiation. These environment-phenotype-genotype associations, together with the result of an experiment simulating an extreme drought event, will be projected into future climatic conditions to predict plant responses to climate change. Using a multidisciplinary and multiscale approach and integrating different data sources, AsterAdapt will answer apt research questions in evolutionary ecology and island biology, while contributing to addressing global priorities regarding the halt of biodiversity loss and the mitigation of the effects of climate change. The development of this project will foster my research independence and maturity, providing a pathway towards establishing myself as a group leader in the field of plant ecology and evolution.

Keywords: oceanic islands,functional traits,adaptive radiations,angiosperms,climate change
The arrival of Homo sapiens in northwestern Europe: a multi-proxy investigation of regional diversity in the Lincombian-Ranisian-Jerzmanowician (LRJ) (ARRIVAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 2119801.0
EU funding (EUR): 2119801.0
Participants: 1
Project status: SIGNED

In 1826, the first LRJ blade point in Britain was found at Kent’s Cavern. ARRIVAL will return to the cave 200 years later to answer the fundamental questions we still ask about these tools - who made them and when? Ground-breaking advances in archaeological science methods over the past decade enable us to study the dynamics of the Neanderthal-Homo sapiens transition in unprecedented resolution but few sites have been explored with the full suite of methods. New findings from Ranis, Germany, have recently proven that Homo sapiens were present in northern Europe between 47,500 - 43,000 years ago, much earlier than previously suspected. These people made stone tools known as the Lincombian-Ranisian-Jerzmanowician (or LRJ), which are found at more than 40 sites across northern Europe and were previously thought to have been made by Neanderthals. Only one high-resolution dataset (Ranis) exists for the LRJ. The lack of additional datasets prevents us from investigating variations between LRJ occupations. ARRIVAL will bring together an international, interdisciplinary team to investigate key LRJ sites using a multi-proxy approach, combining new excavations, chronometric dating, non-destructive collagen screening, palaeoproteomics, isotopic and aDNA analysis with traditional lithic and palaeoecological analysis. ARRIVAL will focus on newly excavated material to produce robust new datasets whilst providing better contextualisation for legacy collections. New methods will be developed to improve the accuracy and reliability of 14C dating in this crucial time-period, enabling us to produce the first robust chronological framework for the LRJ. ARRIVAL will determine if the LRJ can now be considered a reliable proxy for Homo sapiens across its entire range and provide the first high-resolution, regional investigation of LRJ sites to explore the nature and extent of LRJ occupations and the arrival of Homo sapiens in northwestern Europe.

Keywords: palaeolithic,archaeology,radiocarbon,zooms,isotopes,adna,method development,compound specific,middle upper palaeolithic transition,europe
(Mal)adaptative beta-adrenergic regulation of the cardiac voltage-gated sodium channel, Nav1.5 (MALBENA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

Cardiovascular disease is a leading cause of morbidity and mortality in Europe and, in the face of population aging, this statistic is predicted to significantly worsen. One of the major CVD risk factors is represented by the alterations of beta-adrenergic receptors stimulation, which modulates the function of the voltage-gated sodium channel, Nav1.5, in cardiomyocytes. In a healthy heart, beta-adrenergic receptors regulate the function of Nav1.5 to potentiate cardiac contraction during common everyday activities like physical exercise. However, the same pathway promotes and worsens cardiovascular disease such as heart failure. Thus, there is an urgent need to investigate how a healthy physiological response becomes deleterious in order to better understand cardiovascular disease occurrence and hence to improve its treatment. MALBENA will address this challenge through an ambitious and interdisciplinary study that will thoroughly assess molecular and functional modifications of Nav1.5 in the beta-adrenergic receptor-stimulated cardiomyocytes as well as in human failing and non-failing hearts. Such profiling of the physiological and pathological remodeling of Nav1.5 will provide a substantial impact on the novel strategies developing targeted therapies aiming to reduce the cardiovascular disease burden and, at the same time, having little to no side effects on the other organs, since Nav1.5 is nearly exclusive to cardiomyocytes. The combination of unique expertises of the host supervisor, Dr. Céline Marionneau, in phosphoproteomics of Nav1.5, and of the researcher, Dr. Oksana Iamshanova, in Nav1.5 functioning as the macromolecular complex, will enable synergistic implementation of the scientific backgrounds, techniques, and methods to guarantee the successful achievement of MALBENA’s objectives.

Keywords: heart,cardiomyocyte,channelopathy,voltage gated sodium channel,beta adrenergic stimulation,phosphorylation,interactome
Stochastic thermodynamics of biochemical replication (STBR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

The main goal of this project will be to construct a thermodynamically consistent comprehensive model for biochemical replication using stochastic thermodynamics and control theory. I will subjugate the process of kinetic proofreading (KPR) to several thermodynamic bounds that have recently been discovered, in order to study the thermodynamic performance of this process. This will be done by considering the process as a chemical reaction network where a sequence of irreversible steps consume energy to increase replication accuracy and are hence bounded by fundamental no-go theorems such as the thermodynamic uncertainty relation (TUR) or the thermodynamic speed limit (TSL). I then investigate how the topology and reaction rates of the KPR network can be optimized with respect to error rate and dissipation by means of machine learning, to deduce how close biological systems operate to these bounds. Subsequently, I will extend the results to the conformational proofreading (CPR) process, where an energy handicap is added to the free energy to increase binding specificity at the expense of binding affinity. The CPR is a proofreading scheme that does not consume energy by burning ATP/GTP, so the entropy production has its origin in the conformational change. Finally, I test the robustness of the aforementioned KPR and CPR networks. In realistic systems, the kinetic rates can fluctuate as a consequence of e.g., temperature or chemical density variations, which can possibly destabilize the network and lead to more errors in the replication process. This will be done by considering the networks as input-output systems that can be studied by control theory. This provides fundamental bounds such as Bode's sensitivity integral to complement the TUR and TSL. I expect that the research results will lead to a better understanding of the fundamental limits on error correction in biological systems and will inspire further research in biophysics and structural biology.

Keywords: stochastic thermodynamics,kinetic proofreading,conformational proofreading,control theory
A SYstem for reaL-time obserVation of Aeroallergens (SYLVA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Finland,Belgium,Germany,Spain,Serbia,Switzerland,Norway,Lithuania,Italy
Call: New technologies for acquiring in-situ observation datasets to address climate change effects (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3127662.5
EU funding (EUR): 2998677.25
Participants: 12
Project status: SIGNED

Primary biological aerosols (bioaerosols: mainly pollen and fungal spores, but also bacteria and viruses) released into the air by plants, fungi, and other biota, are strongly impacted by climate change. Simultaneously, they also directly affect the climate through interactions with clouds and precipitation. Many bioaerosols, especially pollen and some fungal spores, have allergenic effect on humans. Such aeroallergens affect over 80 million Europeans, reducing their quality of life and costing well over €50 billion/year. Information on bioaerosols is also vital for agriculture and forestry, where timely data about plant development, abundance of pathogens and parasites, as well as invasive species, are necessary for precision-agriculture and knowledge-based technologies. The demand for timely, free, and objective information is currently not met. The overall goal of SYLVA is: To achieve a radical improvement and fill gaps in temporal resolution, timeliness, coverage, and availability of information about aeroallergens and other bioaerosols. SYLVA technological innovations will be accompanied with new infrastructure, distribution and exploitation pathways, and links with stakeholders to ensure technology uptake and sustainability beyond the lifetime of the project. To achieve this goal, the project will: - Develop cutting-edge bioaerosol monitoring technologies - Create bioaerosol monitoring ICT infrastructure and software following open-source principles and connect it to European environmental observing systems - Validate the operational maturity and added-value of bioaerosol monitoring technology through Demonstration Pilots in three European regions - Maximise impact by demonstrating SYLVA innovations to key stakeholders related to climate, health, agriculture, silviculture, and the environment - Ensure the long-term sustainability of bioaerosol technology and infrastructure across Europe
Wireless charging technology for autonomous vehicle (AV) systems to enable dual-mode wireless power transfer (WPT), in both stationary (parked) and dynamic (in-motion) modes of driving (Electreon_EU EIC_SP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Wireless charging technology for autonomous vehicle (AV) systems to enable dual-mode wireless charging in both stationary (parked) and dynamic (in-motion) modes of driving

Keywords: electric vehicles,wireless charging,autonomous vehicles
A Power-to-Heat Long Duration Energy Storage for decarbonizing the industrial thermal processes (ThermalBox)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3558927.14
EU funding (EUR): 2491249.0
Participants: 1
Project status: SIGNED

ThermalBox® combines Power-to-Heat (PtH) electrification technologies with Thermal Energy Storage (TES) systems utilizing sensible heat storage in molten salts to deliver decarbonized industrial process steam, while also providing demand side flexibility services to the grid. The system is primarily powered by renewable electric energy sourced from a renewable asset or through a Power Purchase Agreement (PPA), and it is capable to deliver steam up to 20 barg and 222°C. The Heat Transfer Fluid (HTF) utilized is a eutectic mixture of inorganic molten salts known as HITEC®, extensively used in chemical and petrochemical applications, consisting of potassium nitrate (KNO3), sodium nitrite (NaNO2), and sodium nitrate (NaNO3), at weight percentages of approximately 53%, 40%, and 7%, respectively. The system configuration based on a two-tanks arrangement ensure a smooth and continuous operation and provides operational flexibility by decoupling supply and demand. ThermalBox® has been designed with two sets of tanks located at different elevation (namely, the storage system), an electric heater and a steam generator system. Build to Zero positions ThermalBox® in the small to medium-sized industrial application market, focusing on delivering up to 5 MWth with cost-competitive, optimized design. ThermalBox® decarbonizes industrial heat and provides demand flexibility to electricity system operators, aligned with EU market reforms. The scopes of the EIC Accelerator project are to manufacture, install and test our 2.5 MWth Basic Unit, to industrialize the ThermalBox production process and to enter the international market.

Keywords: electrothermal energy storage,low to medium industrial heat,long duration energy storage,decarbonization
Optimized Soil Revitalization for Resilient Agriculture: Customizing Mycorrhizal Diversity with Predictive Modeling (MYCOPHYTO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Agricultural systems are becoming more vulnerable due to soil degradation, which affects 60% of European lands because of intensive soil work. This leads to a loss of biodiversity and a disconnection between soil microorganisms and plants, resulting in less productive crops that are more susceptible to climate change. Consequently, the ability to meet food demands by 2050 is threatened. Conventional farming practices worsen the problem with excessive fertilizer use, causing soil toxicity, quality deterioration, loss of beneficial microflora, and water pollution, posing risks to human health and ecosystem sustainability. Biostimulants are designed to reduce fertilizer usage and improve crop conditions but face challenges such as application control, potential pollutants, and inconsistent performance. Arbuscular Mycorrhizal Fungi (AMF) offer a sustainable solution by enhancing nutrient and water uptake and regenerating soil biodiversity. However, their application is hindered by complex soil conditions, heavy tillage, specificity to plant hosts, and difficulties in identification and isolation. Consequently, fewer than 10 strains are available on the market, and most products fail to achieve effective root colonization, despite the existence of over 350 species in nature. Mycophyto uses native mycorrhizae, enhanced by our data prediction model, to boost crop yields, regenerate soil, and reduce the use of chemicals, fertilizers, and water. Our innovative approach will revitalize soil to preserve agriculture by enhancing soil biodiversity with tailored mycorrhizal fungi suited to specific soils and crops. We aim to lead the global biostimulant and soil treatment market, restore soil biodiversity and build a climate-resilient agriculture, contributing to the goals of SDG, Green deal and the EU’s Soil Strategy.

Keywords: resilient agriculture,soil biodiversity,soil health,climate resilience,biostimulant,mycorrhization,food productivity
Growing Up Across Borders: Experiences of Young People in Forced Migration (GRABS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2213225.0
EU funding (EUR): 2213225.0
Participants: 1
Project status: SIGNED

Since 2015, over 5 million people have arrived, or tried to arrive in the European Union seeking refuge. Other refugee receiving countries are faced with similar situations. Many of these refugees are young people. But whilst much has been written about the experiences of adult refugees and to a lesser extent about unaccompanied minors, there is very little research on the experiences of young refugees who are not (or are not recognized as) “unaccompanied”, and specifically about how these experiences impact their pathways to adulthood in or across borders. This in turn leads to an absence of effective policies to protect young people and to ensure their access to services which are essential to their well-being – both as young people and for their future adult lives. The project aims to provide timely new research focusing on various aspects of the experience of these young people growing up in a situation of forced migration, in order to contribute research both on youth, and on migration/mobility. In doing so it will also make recommendations on how to better support rights, agency and resilience of these young people. The research will be carried out in a range of countries in Europe (France, Greece, UK) and outside (Canada, South Africa) to analyse impacts of different social, legal and political contexts. The development of innovative methodologies combining traditional qualitative methods with social media research and digital communication tools, and emphasizing participatory research methods, will enhance the participation and self-expression of young refugees to allow them to “narrate” their lives and experiences. A feminist intersectional approach avoids essentialising young people as « vulnerable » and understands age as interacting with other social categorizations such as gender or race, to determine individual’s risks, vulnerabilities, but also possibilities for agency and resilience.

Keywords: forced migration,borders,youth,gender,vulnerability,intersectionality,agency,mobility