Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Working collaboratively with vulnerable women to identify the best implementation gains by screening cervical cancer more effectively in European countries (CBIG-SCREEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Estonia,Italy,Ireland,Belgium,Romania,Bulgaria,France,France,France,United Kingdom,Denmark,Portugal
Call: Global Alliance for Chronic Diseases (GACD) - Prevention and/or early diagnosis of cancer (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 3661850.0
EU funding (EUR): 3661850.0
Participants: 16
Project status: SIGNED

CBIG-SCREEN aims to tackle inequality in cervical cancer screening (CCS) continuum. Though CCS programmes drastically reduce cervical cancer mortality, they remain largely inaccessible and underused by subpopulations of vulnerable women, creating inequality in the European healthcare system. CCS programmes rarely reach the subgroups at highest risk, adding to the challenges underserved populations already face in their efforts to maintain their socioeconomic and physical health. CBIG-SCREEN will create a Europe-wide knowledge framework around barriers to CCS and generate policies, programmes, communications and other required services to meet the needs of underserved sub-populations of women with inherent high-risk of cervical cancer and low (perceived) access to proper healthcare routes. CBIG-SCREEN will be working collaboratively with vulnerable and underserved women to identify the interventions that will more effectively engage and retain them in CCS programmes in European countries. Through stakeholder engagement, mathematical analyses, and structured reviews of current policies, our consortium will collect, analyse, and share knowledge about shortcomings and opportunities for improving CCS continuum that will directly translate to policy recommendations and be used to adapt and extend national CCS with interventions tailored to vulnerable subpopulations. By deploying screening programmes aimed specifically to serve vulnerable women we can thus leverage limited resources to quickly reduce CCS mortality. Our interventions aim to reduce health inequality by increasing screening ratios among vulnerable women from 26% to 45% and intend to offer support to policymakers and national programmes to help Europe reach or exceed the WHO 2030 target of screening >70% of women for cervical cancer. CBIG-SCREEN project will realise the needed improvements in the European screening policies to address the current inequities and thus accelerate cervical cancer elimination.

Keywords: cervical cancer,incentives,implementation,equity,proportional universalism,discrete choice experiments,migration,cost effectiveness,socioeconomic inequalities,behaviour
Unravelling the molecular basis of the Kupffer cell-hepatocyte crosstalk and its role in the functional specialization of liver Kupffer cells. (Liver ID3ntity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Macrophages perform unique tissue-specific functions that are essential for the homeostasis of each organ. To perform these tissue-specific functions, each resident macrophage expresses a relatively unique gene expression profile controlled by specific transcription factors. Kupffer cells (KCs) are the biggest macrophage population of the body and represent 10% of all liver cells. The Guilliams lab recently reported that each KC projects an important part of its body across the liver endothelial cell barrier to be in close contact with hepatocytes. We have established that the transcription factor ID3 is highly expressed in murine KCs as compared to other macrophages, is highly preserved in KCs across 5 different species and is essential for controlling KC identity in vivo. We have recently reported that monocytes co-cultured with hepatocytes, but not with liver endothelial cells or liver fibroblasts, acquire strong ID3 expression, indicating that hepatocyte-derived signals induce ID3 expression. The objective of this proposal is to utilise ID3-expression in KCs to unravel the molecular mechanisms underlying the KC-Hepatocyte crosstalk. Since nothing is known about the hepatocyte-derived signals that induce ID3 expression in myeloid cells, I will utilize a genome-wide in vitro CRISPR screen to identify positive and negative regulators of the ID3 expression induced by hepatocytes. The result of this in vitro ID3-screen will then be combined with potential regulators predicted through epigenetic and ligand-receptor inference algorithms, to obtain our top candidates for genes involved in the liver KC-Hepatocyte crosstalk. Using cutting-edge technology combining direct guide-RNA capture with single-cell RNA sequencing, I will then perform a targeted in vivo CRISPR screen. Finally, I will knock-down the most interesting hits from this in vivo screen using CRE-Lox technology to understand the role of specific KC-Hepatocyte interactions in liver homeostasis and pathology.

Keywords: cell cell interactions,tissue imprinting,tissue resident macrophages,macrophage niche,liver kupffer cells
Development of a Low CO2 Iron and Steelmaking Integrated Process Route for a Sustainable European Steel Industry (LoCO2Fe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Austria,Germany,France,Netherlands,United Kingdom,Luxembourg
Call: Sustainable Industry Low Carbon II (H2020-SILC-II-2014, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 14836830.0
EU funding (EUR): 7418415.02
Participants: 7
Project status: CLOSED

Over the past decade, the steel industry in Europe has been spending a lot of effort in Research and Development of technologies that help in achieving the EU’s CO2 emissions targets and reduce the cost of EU ETS compliance. That has been done through a combination of large scale projects which were part publicly funded with European funding and partly through smaller privately funded research activities. From the initial stages of feasibility studies, several technologies were put forward for further development, one of which is the HIsarna smelting reduction process The objective for the current proposal is to prove the capability of the HIsarna ironmaking technology to achieve at least 35% reduction in CO2 emission intensity, compared to blast furnace operated site based on Best Available Technology Currently Installed. This will be achieved through: -Change operation parameters in order to achieve at least 35% CO2 intensity reduction per tonne of hot rolled coil compared to the conventional blast furnace – BOF route through: >Combined iron ore and scrap operation with a scrap rate of 350kg/thm; >Partially replacing coal injection with sustainable biomass injection (at least 40%); >Minimising coal rate by maximising energy use in the reactor, through balancing the energy between the upper and lower part of the reactor (<700 kg coal per tonne hot metal in pilot reactor); >Using limestone instead of burnt lime as a fluxing agent; >Quantifying potential for energy recovery from hot off-gas by installing boiler test panels; >Making the process ‘CCS ready’ by having process gas suitable for CCS with little or no processing by replacing compressed air and N2 carrier gasses with CO2 and CH4 as carrier gas; -Operation of the HIsarna pilot plant for several months continuously in order to establish process and equipment stability; -Test process conditions and validate for scale up to 0.8 Mtpa plant

Keywords: co2 emission intensity,steel industry
Calibration and integration of peripheral and foveal information in human vision (PERFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-06-30
Duration (months): 63.0
Total project cost (EUR): 1429800.0
EU funding (EUR): 1429800.0
Participants: 1
Project status: CLOSED

Human visual perception is one of the best-studied areas of research on the human mind. However, 99% of that research is concentrated on the central region making up less than 1% of our visual field. This is the region that gets mapped onto the fovea, where vision is best. However, information from the peripheral parts of a scene is highly important. Mediated by attention and eye movements, it is essential for guiding us through our environment. In the brain, the foveal and peripheral parts of the visual field undergo vastly different processing regimes. Since objects normally do not change their appearance, whether we view them foveally or peripherally, our visual system must integrate and calibrate peripheral information before an eye movement with foveal information after an eye movement. We are planning to address these processes in four series of experiments. First, we will study the perception of basic visual features, such as orientation, numerosity and colour across the visual field and their integration in peripheral and foveal vision across eye movements. Second, we will investigate how this integration is supported by attention and memory resources. Third, since the integration requires learning and plasticity, we will track changes across the life span and study how healthy subjects can learn to compensate for artificial changes of peripheral and foveal vision. And fourth, we will explore whether we can manipulate the integration process for the optimal guidance of eye movements in complex natural search tasks. The project will provide insights how the brain achieves a stable and homogeneous representation of the visual environment despite the ever changing sensory input and the inhomogeneity of processing across the visual field. We will reveal the basic learning mechanisms that allow a continuous calibration of peripheral and foveal vision, and that could be used in the long run for behavioural training of patients suffering from vision impairments.

Keywords: perception,eye movements,attention,learning,memory,development,aging
HERA Joint Research Programme Public Spaces: Culture and Integration in Europe (HERA-JRP-PS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: ERA-NET Cofund
Partnership: HERA-JRP-PS (ERA-NET)
Countries involved: Estonia,Iceland,Austria,Spain,Ireland,Italy,Germany,Norway,Finland,Lithuania,Poland,Slovenia,Sweden,Switzerland,Belgium,Croatia,Slovakia,Latvia,France,Czechia,Netherlands,Denmark,Luxembourg,United Kingdom
Call: Culture, integration and European public space (H2020-SC6-CULT-COOP-2017-one-stage, 2017)
Start date: 2017-08-01
End date: 2023-01-31
Duration (months): 66.0
Total project cost (EUR): 20513750.0
EU funding (EUR): 5000000.0
Participants: 27
Project status: CLOSED

The HERA Joint Research Programme European Public Space, Culture and Integration (HERA JRP PS) consortium will establish a 4th joint transnational programme for multi-disciplinary research. The HERA JRP PS involves the launch of a joint Call for Proposals and a commonly-agreed two-stage evaluation process involving an independent, international Review Panel. The consortium expects to fund about 20 transnational humanities centred projects of ~1 M EUR each. The aim of the HERA “Public spaces” programme will be to deepen the theoretical and empirical cultural understanding of public spaces in a European context. The programme has been designed to facilitate a broad range of cultural approaches to conceptualising public space, its structural and processual formations, and its possible outcomes in terms of integration, exclusion, disintegration, fragmentation, hybridization, amalgamation or transmission. Twenty-four organisations from 24 EU countries have pooled a substantial amount of their humanities research funding for this new HERA JRP increasing the efficiency and impact of public funding. The HERA JRP PS consortium will also actively support knowledge exchange activities and stimulate wider dissemination about the valuable contributions of new humanities research. Furthermore, the HERA JRP PS will pursue additional activities aiming at international capacity-building in humanities research and explore and prepare new joint actions.

Keywords: humanities
New business models for innovative energy service bundles for residential consumers (frESCO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Austria,Spain,Spain,Cyprus,Greece,Greece,Croatia,Croatia,Belgium,Greece,France
Call: Enabling next-generation of smart energy services valorising energy efficiency and flexibility at demand-side as energy resource (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 5127738.75
EU funding (EUR): 3987195.0
Participants: 18
Project status: SIGNED

Despite the large economic energy saving potential in the EU, the energy service companies (ESCOs) market for residential buildings is much less developed than in other demand sectors (e.g. the industry or public/service sectors). Besides sector cross-cutting barriers (e.g. low energy prices, lack of information and awareness, lack of appropriate forms of finance) there are specific barriers which make a large-scale application of the ESCO model for residential buildings particularly difficult (e.g. lack scale or lack the necessary energy intensity to justify investment within the structure of present-day EPC model). In this context, frESCO aims to engage with ESCOs and aggregators and enable the deployment of innovative business models on the basis of novel integrated energy service bundles that properly combine and remunerate local flexibility for optimizing local energy performance both in the form of energy efficiency and demand side management. Such new service and business models will bring under common Pay for Performance Contracts (extended form of current EPCs) two currently differentiated service offerings to enable the realization of next-generation smart energy service packages. The strong presence of the industry in the consortium (2 ESCOs, 2 aggregators, 3 ICT and technology providers and 2 engineering companies) and the end-users (1 Cooperative and 1 Hotel), supported by 3 knowledgable RTOs, will ensure the market uptake of frESCOs new business models. frESCO's new business models will be demonstrated in 4 different pilots (Spain, France, Croatian and Greece) with complementary characteristics in terms of building typology (single-/multi-family), climate, regulation, energy consumption, energy assets, consumer groups, etc., thus facilitating the replicability of frESCO's solutions across Europe. Overall, frESCO aims to directly achieve a primary savings of 464 MWh/yr and a reduction of 108 tCO2/yr and trigger 28.3M€ investment during the replication

Keywords: business models,escos,energy efficiency,flexibility,aggregators,residential consumers,performace measurement and verification,big data,smart homes
Sensing for Justice - Citizen Sensing as a source of evidence in environmental justice litigation and as a tool for environmental mediation (SensJus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

On June 27, 2019, a landmark court decision was released in Texas, in which a judge found the petrochemical company Formosa Plastics Corporation, liable for violating the Clean Water Act because of plastic discharge into local waters. The case was brought by a civic group based in part on citizen sensed-evidence which involved volunteer observations performed over years. This practice entailing grassroots-driven environmental monitoring could be qualified as ‘Citizen Science’ and, more specifically, ‘Citizen Sensing’. The contamination could not be proved through existing data held by competent authorities since the company never filed any record of pollution with the competent authority. Rather, the monitoring and data collection was almost entirely conducted by local residents. Cases such as the Formosa litigation are expected to increase drastically. They pose urgent research questions. Above all, the case motivates an investigation of the potential of introducing Citizen Sensing as a source of evidence in litigation over environmental wrongdoings. Furthermore, Citizen Sensing may also play a role in avoiding the court stage, as a tool to mediate the environmental conflict and to steer the responsible company to adopt an environmentally-compliant behaviour. Related research is still in its infancy. The few championing actors in the debate are located in the U.S., not flanked by a parallel inquiry from the European perspective. The key objective of the Sensing for Justice project is to fill this knowledge gap in order to avoid a possible scientific and legislative vacuum, and provide newly required research capacity in the EU. The research will be hosted by the European Commission Joint Research Centre, currently leading actor in the research on Citizen Science for environmental monitoring and reporting, which will allow me to play a crucial role in the enactment of measures to release Citizen Science for litigation and mediation’s potential across the EU.

Keywords: citizen sensing,environmental citizen science,environmental justice and rights,environmental litigation,environmental mediation,european environmental law and policy,law and technology
Sculpting memories during sleep (SPIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United States,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1963358.0
EU funding (EUR): 1893553.0
Participants: 2
Project status: SIGNED

Our ability to remember past events and experiences lies at the core of cognition and behaviour. But how do fleeting moments get converted into durable memory traces? Recent work has highlighted the pivotal role of post-learning sleep for successful memory consolidation, the process of stabilising new memories over time. However, little is known about the neurophysiological mechanisms through which the sleeping brain consolidates new memories. Not only has this left a gap in our understanding of memory formation as a whole, but also the means to modulate memories during sleep have remained underexplored. SPIN will test the exciting hypothesis that particular electrophysiological signatures of sleep, namely sleep spindles, are the mechanistic vehicle driving memory consolidation. Specifically, I hypothesise that in coordination with hippocampal reactivation events, sleep spindles are deployed to cortical learning sites where they induce lasting structural changes. Using intracranial recordings from the human hippocampus (measuring single neuron firing and associated ‘ripple’ oscillations) and from an array of cortical areas, we will first establish whether spindles are temporally aligned with hippocampal reactivation events. Next, we will use high-density scalp EEG and functional as well as structural MRI in healthy participants to test whether spindle deployment to cortical learning sites predicts structural changes in these regions. To assert causality, we will examine the effects of invasive spindle perturbation in patients on memory consolidation. Finally, we will experimentally enhance local spindles to harness their potential as a tool for boosting human memory. In sum, SPIN will use an unprecedented array of human brain recording and stimulation techniques to provide a mechanistic link between learning, sleep and structural brain changes, culminating in novel tools to enhance human learning and memory.

Keywords: memory,sleep,consolidation,brain imaging,brain stimulation