Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A disruptive technology for vaccines manufacturing based on Self-Assembled Polymeric Nanoparticulate systems (SAP-Nano)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bionanoplus detected the major problems faced by many pharmaceutical, veterinary and cosmetic sector manufacturers to develop products using nanotechnology. It seemed impossible and costly to move a product developed in the laboratory to the industrial manufacturing of the product. To solve this issue Bionanoplus has developed and patented a highly versatile and easily scalable technology to encapsulate antigens and other molecules, called SAP-Nano. Bionanoplus has solved the scalability problem of traditional nanoparticle manufacturing methods avoiding the use of volatile organic solvents, thus it ensures an easy and inexpensive production of any scale, which can be performed using standard equipment and techniques. SAP-Nano technology has been successfully implemented with two clients, a fish vaccines manufacturer and a pharmaceutical company. Now Bionanoplus plan to launch his technology in the vaccines manufacturers market, firstly on to the PRRSV vaccines manufacturers market. It was estimated that losses due to PRRSV cost the swine industry EUR 1.5 billion per year in Europe and USD 664 million per year in the USA. SAP-Nano enables the development of unique vaccines, which are significantly more effective than conventional vaccines. Phase 1 of SME Instrument represents an opportunity to get a thorough business plan to minimize risks. The main objective is to perform a feasibility study to verify the economic viability in the vaccines manufacturers market and design a suitable business model, and the commercial, marketing and industrial strategies. The SAP-Nano proposal was presented for the first time to the 25-11-2015 call (NMP-25-2015-1-P) achieving a total score of 12,84. The lower point in the evaluation was Impact (score: 4.21). B+ has met potential clients in order to know the needs and requirement to develop new vaccines. The business case has also been improved. This new information has been included in this new submission of the proposal.

Keywords: disruptive,solution,manufacturing,vaccine,nanoparticle,self assembled,polymer,scalable,prrs,virus,antigen,veterinary,pigs,volatile,solvent,adjuvant,delivery
The molecular and cellular logic of vertebrate neural development (LogNeuroDev)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 2357000.0
EU funding (EUR): 2357000.0
Participants: 1
Project status: SIGNED

A central problem in biology and key to realising the potential of regenerative medicine is understanding the mechanisms that produce and organize cells in the complex tissues of an embryo. In broad terms, initially uncommitted progenitors acquire their fate in response to signals that control transcriptional programmes. These programmes drive cells through spatial and temporal successions of states that gradually refine cell identity. How these states are established and cell fate decisions implemented is poorly understood. To address this we use an experimentally tractable system – the formation of defined populations of progenitors in the vertebrate spinal cord. We take an interdisciplinary approach that combines our in vivo expertise with three recent advances in our group. First, we have developed in vitro differentiation systems and microfluidic devices that use embryonic stem cells to recapitulate development processes. Second, we have embraced new technologies that provide unprecedented ability to manipulate and assay single cells. Finally, we have established interdisciplinary collaborations to develop computational tools and construct data driven mathematical models. Using these approaches, alongside established embryological methods, we will establish a platform for manipulating and analysing mechanisms by which the multipotent progenitors that form the spinal cord acquire specific identities. We will identify the rules by which cells make decisions and we will define the design logic and network architectures that lead to distinct cell fate choices. The ability to: (i) follow the trajectory of a cell as it transitions to a specific neuronal subtype in vivo; (ii) manipulate the process in vitro and in vivo; and (iii) model it in silico, offers a unique system for understanding organogenesis. Together these approaches will provide the knowledge and technical foundations for rational, predictive tissue engineering of the spinal cord.

Keywords: cell fate decisions,quantitative biology,morphogen,gene regulatory networks,tissue engineering,transcriptional networks
Architectural Culture of the Early Modern Eastern Adriatic (AdriArchCult)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999750.0
EU funding (EUR): 1999750.0
Participants: 1
Project status: SIGNED

During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will investigate the trans-border and trans-confessional character of the architectural market, thus providing an innovative model for a study of such phenomena across Europe.

Keywords: architectural history,eastern adriatic,early modern period,architectural culture
Secure and Wireless Multimodal Biometric Scanning Device for Passenger Verification Targeting Land and Sea Border Control (eBORDER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Greece,United Kingdom,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1025800.0
EU funding (EUR): 1025800.0
Participants: 5
Project status: SIGNED

Every year a large number of visitors enter the European Union (EU) by cars, buses, trains or ships through land-border crossing points or sea ports bringing significant economic benefits; in particular, 9% of Europe’s GDP comes from tourism. This trend is set to continue, as Europe further considers visa liberalization agreements in a bid to sustain their competitive stance in the global tourism market. This will create major implications on the security and border management in the EU, as well as diminishing the Quality of Experience for passenger travel. Existing directives for controlling border crossing is to conduct checks using biometric data in conjunction with VIS (Visa Information Systems), as specified in the Schengen Border Code. However, current biometric systems rely on one mode of biometric data, that can at times can lead to false identification, in particular under uncontrolled conditions during live sample acquisition. Moreover, the current crop of scanning devices are limited in coverage and typically have fixed links, thus confining the range of border control applications and compromising the comfort of passengers. We aim to go beyond and propose an innovative passenger-centric biometric system that authenticates “on the fly”. We combine the scientific field of wireless security, biometric recognition and data fusion to develop a secure and wireless multimodal biometric scanning device for passenger verification targeting land and sea border control applications. The research approach is the basis for a RISE training action that we refer to as eBORDER, that is foreseen to enhance both the career potential of staff members and innovation capacity at the institutional level. In this context, this action brings together key players from industry and academia with complementary expertise on security, biometrics, data fusion and practical experimentation to train staff by research through intersectorial and international staff exchanges.

Keywords: biometric verification,facial recognition,fingerprint recognition,data fusion,wireless security
OPENing UP new methods, indicators and tools for peer review, impact measurement and dissemination of research results (OpenUP)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Germany,Austria,Germany,Italy,Austria,Greece,Switzerland,Lithuania,Netherlands
Call: Innovative approach to release and disseminate research results and measure their impact (H2020-GARRI-2015-1, 2015)
Start date: 2016-06-01
End date: 2018-11-30
Duration (months): 30.0
Total project cost (EUR): 2223557.5
EU funding (EUR): 1951932.5
Participants: 9
Project status: CLOSED

Open Access and Open Scholarship have revolutionized the way scholarly artefacts are evaluated and published, while the introduction of new technologies and media in scientific workflows has changed the “how and to whom” science is communicated, and how stakeholders interact with the scientific community. OpenUP addresses key aspects and challenges of the currently transforming science landscape and aspires to come up with a cohesive framework for the review-disseminate-assess phases of the research life cycle that is fit to support and promote Open Science. Its main objectives are to a) identify and determine ground-breaking mechanisms, processes and tools for peer-review for all types of research results (publications, data, software), b) explore, identify and classify innovative dissemination mechanisms with an outreach aim towards businesses and industry, education, and society as a whole, and c) analyse a set of novel indicators that assess the impact of research results and correlate them of channels of dissemination. It will do so by following a user-centred, evidence-based approach, engaging all stakeholders (researchers, publishers, funders, institutions, industry, public) in an open dialogue through a series of workshops, conferences and training, and validating all interim results via a set of seven pilots involving communities from four research disciplines: life sciences, social sciences, arts & humanities, energy. It will finally produce a set of concrete, practical, validated policy recommendations & guidelines for national and European stakeholders, including EU institutions, a valuable tool in advancing a more open and gender-sensitive science system. OpenUP partners bring expertise and capacity for evaluating and promoting new approaches in support of open science with decade-long experiences in establishing OA e-Infrastructures, excellent skills and innovative approaches for dissemination, impact indicators and policy design and implementation.

Keywords: open access,open science,peer review,impact measurement and indicators,altmetrics,innovative dissemination framework,gender,stakeholder engagement,use cases,pilot studies,novel methods,tools
Designing of Environmentally Friendly Colloidal Nanocrystals for Sustainable Solar Cell Manufacturing (SUSNASOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

High-efficiency and low-cost solar cells are demanding to address the issue of the increasing global energy consumption and greenhouse gases emission. This stimulates the evolution of photovoltaic (PV) technologies from crystalline silicon (first generation) to thin film PV (second generation) with promises in further lowered cost and new building integrated applications (BIPV). However, facing problems of toxic and scarce materials (e.g. CdTe, CIGS, etc.) as well as the detrimental issue of defects (kesterite or CZTS) in the available solar cell technologies, SUSNASOL propose to build the new platform of low-temperature, high-throughput manufacturing for antisite-disorder suppressed, high-efficiency Ag2ZnSn(S,Se)4 or (Cu,Ag)2ZnSn(S,Se)4 (CAZTS) nanocrystal (NC) solar cells. By referring to many scientific breakthroughs in the field of thin film and colloidal NCs photovoltaics in recent years, and combining the extensive expertise in colloidal NC PVs of the hosting group with the developed material processing skills spanning chemistry, physics, and engineering of the experienced research (ER), this project aims at specific research objectives including designing environment-friendly, CRM-free nanomaterials with excellent optoelectronic properties; exploiting nanoscale tenability via colloidal chemistry to passivate this new class of NC materials; applying only mild sintering, and optimizing new device architecture (e.g. superstrate p-i-n, bulk nano-heterojunctions,etc.) to unlock the full potential of CAZTS NCs. This fellowship will be carried out at ICFO – The Institute of Photonic Sciences in Spain, supervised by Prof. Gerasimos Konstantatos.

Keywords: ag incorporated kesterite
Structured Reactors with INTensified ENergy Transfer for Breakthrough Catalytic Technologies (INTENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-04-30
Duration (months): 66.0
Total project cost (EUR): 2484648.75
EU funding (EUR): 2484648.0
Participants: 1
Project status: CLOSED

Critically important heterogeneous catalytic reactions for energy conversion and chemicals production have been run for several decades in fixed bed reactors randomly packed with catalyst pellets, whose operation is intrinsically limited by slow heat removal/supply. There is urgent need for a new generation of process equipment and chemical reactors to address the current quest for process intensification. I propose that a game-changing alternative is provided by structured reactors wherein the catalyst is washcoated onto or packed into structured substrates, like honeycomb monoliths, open-cell foams or other cellular materials, fabricated with highly conductive metallic (Al, Cu) materials. The goal of this project is to fully elucidate fundamental and engineering properties of such novel conductive structured catalysts, investigate new concepts for their design, manufacturing, catalytic activation and operation (e.g. 3D printing, packed foams, energy supply by solar irradiation), and demonstrate their potential for a quantum leap in the intensification of three crucial catalytic processes for the production of energy vectors: i) distributed H2 generation via efficient small-size reformers; ii) conversion of syngas to clean synthetic fuels in compact (e.g. skid-mounted) reactors; iii) production of solar H2. To this purpose I will combine advanced CFD modelling with lab-scale experimentation in order to identify the optimal structure-performance relation of existing and novel substrates, use such new knowledge to design optimized prototypes, apply unconventional additive manufacturing technologies for their production, and construct a semi-industrial tubular pilot reactor to test them at a representative scale. The project results will enable novel reactor designs based on tuning geometry, materials and configurations of the conductive internals to match the activity - selectivity demands of specific process applications, while impacting also other research areas.

Keywords: structured catalysts and reactors,open cell foams,advanced materials for process intensification
Infrastructuring Time in Smart Urbanism and Urban Transitions (INFRATIME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Japan
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-30
End date: 2023-10-29
Duration (months): 36.0
Total project cost (EUR): 258498.24
EU funding (EUR): 258498.24
Participants: 2
Project status: SIGNED

The agenda set by climate change is urgent and accelerating, and cities are at the forefront to respond to climate change effects, to harness the resources for sustainable transitions and to adopt long-term policies and strategies for viable urban futures by 2030-2050. At the same time, existing networked data infrastructures allow the everyday management of cities (e.g. mobility, energy, water) and also interact with the efforts to achieve the climate targets. Yet, most recent scientific evidence shows that the sustainability efforts are jeopardised by existing infrastructures and a further effort is needed already by 2030 to stop irreversible damage from climate change. Subsequently, cities need to revise their climate plans, anticipating their actions and aligning their sustainability goals to the new scenarios. The tensions between the urgent agenda of climate change, the testing of sustainable urban futures and the actual ICT infrastructures already in place for urban management produce multiple temporal interferences that influence the paths towards sustainability. Through INFRATIME, I will develop an innovative approach to understand the combined temporality and rhythm of urban transitions and smart urbanism. In so doing, I intend to offer relevant insights to better re-temporalize urban transformations to the climate change agenda. The partnership between the University of Bologna (IT) as Beneficiary and the University of Tokyo (JP) as Third Country organisation, including the planned inter-sectoral secondment in Nordregio (SE), will offer the ideal platform to pursue the research objectives. The Fellowship will thus ensure international, intersectoral and interdisciplinary training and supervision at the highest standards, allowing me to deliver scientific excellence, to increase my employability across academic and non-academic sectors in a European and global context, and ultimately achieve a leading position in the field of sustainable smart urbanism.

Keywords: time,data infrastructures,smart cities,urban transitions,experimental urbanism,institutional change,urban governance,sustainability