Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Intramolecular optical microscopy with sub-nm spatial resolution in single biomolecules and single-protein sequencing (IntraMol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Fluorescence microscopy has witnessed a true resolution revolution in the past decades. The invention of methods circumventing the classical diffraction limit of ≈200 nm has allowed researchers – for the first time – to reach sub-diffraction resolution with optical fluorescence microscopy. With these so-called super-resolution techniques, processes within cells can be observed at thus far unprecedented spatial resolutions. However, while incumbent super-resolution approaches enable researchers to resolve intermolecular distances between e.g. protein molecules in small protein clusters, the final frontier in optical bioimaging to resolve intramolecular distances in the sub-nm regime for single molecules is still elusive. With this research proposal, I want to develop and apply a paradigm-shifting imaging technology that allows intramolecular optical microscopy with sub-nm spatial resolution in single biomolecules. To achieve this goal, I will combine DNA-Point Accumulation Imaging Nanoscale Topography (DNA-PAINT) with DNA Exchange to overcome the current limit of optical nanoscopy in terms of spatial resolution. To do so, I will build a microscope with ultra-high stability and sensitivity. The project is conceived as an integral approach including the design of optics, instrumentation, labelling probes and data analysis. Such a capability provided by the project IntraMol would be a game changer in fluorescence microscopy, as it could – for the first time – allow scientists to resolve intramolecular distances e.g. within single proteins, thus enabling structural biology studies and provide insights into conformations of proteins even enable single-molecule protein sequencing using optical microscopy in situ.

Keywords: super resolution microscopy,dna paint,single molecule protein sequencing,proteomics,fluorescence
Transcatheter Ventricular Repair Device for treatment of Heart Failure Patients (V-sling)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-05-01
End date: 2026-04-30
Duration (months): 48.0
Total project cost (EUR): 8531525.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Heart failure (HF) represents a major public health concern, affecting around 13M people worldwide. A major risk factor for HF is a myocardial infarction, which causes ventricular remodelling, during which the ventricle enlarges, making the heart even less effective at pumping blood, and results in displacement of the papillary muscle. Progressive papillary muscle displacement leads to severe Functional Mitral Regurgitation in about 20% of the patients, the only ones currently receiving treatment because of the severity of the condition. The remaining 80% of patients don’t experience severe FMR and are not considered for surgery: they will continue to suffer, and likely die since there is no therapeutic option available. Cardiac Success develops the V-sling system, a transcatheter ventricular repair device to improve cardiac function in HF patients. The objectives of the project are to finalize product optimization, complete V&V and pre-clinical testing, and perform the FIH study.

Keywords: heart,heart failure,transcatheter procedure,hospitals,implant,papillary muscle sling
Utilizing Scattering-Based Communication to Gain Environmental Awareness in Millimetre Wave Communication Systems (Green-UBacam)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

This proposal contributes to sustainable Internet of Things (IoT) technologies and future mobile communications with promising societal benefits. The aim is to integrate energy- and spectrum-efficiency scattering-based communication (SC) technologies into the next-generation communications operating in the millimetre wave (mmWave) band. The objectives will gain better environmental awareness via enhancing the SC system performance and assisting mmWave directional transmission by attaching backscatter devices (BD) to the user equipment to be served. The latter is a highly innovative scheme because, unlike available solutions that depend on antenna hardware, it utilizes the malleability of BD modulations to facilitate the estimation of directions. This scheme will improve the implementational degree of freedom, and potentially shorten the training period compared to the techniques that do not consider BDs. The core idea of addressing the problems is to examine the wireless channel altered by the BD modulation. I consider that a BD applies frequency modulation to create an artificial Doppler shift to the signal. This leads us to investigate the delay-Doppler profile of the received signal which provides information on the BD location and hence, estimates the channel altered by the BD. Moreover, applying frequency modulation with different frequency shifts on different BDs will help identify multiple BDs. The proposal will approach the problem at a fundamental and applied level, touching multidisciplinary knowledge including system and communication engineering, especially high-frequency and mobile technology, applied mathematics, and signal processing. There will be continuous knowledge transfer among the host, the supervisor, the collaborators, and the researcher. The research training will be complemented by a set of transferable skills including Self- and Team-Leadership, Pedagogy, and Communication, which will make the researcher more employable across sectors.

Keywords: scattering based communications,5g beyond and 6g,beamforming technology,millimetre wave communications,multi input multi output mimo
Quantum Materials for Quantum Devices (QuantuMDs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2457970.0
EU funding (EUR): 2457970.0
Participants: 1
Project status: SIGNED

In the past decade the study of Quantum Materials for Quantum Devices (QuantuMDs) has been recognized as an important research goal in both academia and industry. QuantuMDs are predicted to be the building blocks of next-generation modern technology. The material group most suitable for use in QuantuMDs is the group of transition metal dichalcogenides (TMDs), which exhibit exotic properties, such as superconductivity, charge order, Mott physics and topological states. My main goal is to develop new and exotic QuantuMDs from a variety of pure or intercalated TMDs; these new materials will enable the establishment of a new material platform suitable for quantum technology. I will pursue the fabrication and investigation of various highly correlated systems via multiple measurement techniques including electrical current pulse manipulation. I will adopt a unique combined approach of material synthesis control, high-end device fabrication and broad measurement techniques. My ability to perform a full experimental cycle on any system studied, from crystal growth to advanced fabrication and application, will enable me to undertake the most complex problems and produce creative routes to achieve the proposal goal. The impact of this work will be two-fold; First, the manipulation of exotic phases will open vast scientific possibilities in the exploration of nontrivial physical effects, specifically of single-material low-dimensional highly correlated condensed matter systems. Second, the ultra-low power, ultra-fast dynamics and robustness towards external unwanted perturbations of our expected QuantuMDs will create unlimited opportunities for the future of technological applications. The enticing possibilities include ultra-fast slidetronics-based devices, fault-tolerant superconducting quantum bits and low-power topological magnetic random-access memory devices.

Keywords: quantum materials,quantum devices,superconducting qbits,spintronics,highly correlated electronic systems,ultra fast low power memory,novel magnetism for applications,low dimensional systems,intercalated systems,inorganic single crystal synthesis,focused ion beam machining,high resolution nano fabrication
Structural mechanisms of centromeric nucleation of the kinetochore complex (CENStruK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Ensuring accurate segregation of the genetic material is an essential life process. In eukaryotes, such as humans and yeasts, regions of DNA known as centromeres nucleate the assembly of the megadalton kinetochore complex, which connects to and regulates spindle-microtubules that drive chromosome segregation. While significant progress has been made in the past decade in understanding the structural architecture of the inner kinetochore Ctf19 complex (CCAN in humans), a fundamental gap in knowledge remains concerning how the inner kinetochore is assembled upon native centromeric DNA. This gap is particularly important, as it addresses critical mechanistic steps involved in maintaining genome integrity across cell divisions, evolution, and disease. The budding yeast Saccharomyces cerevisiae is a fundamental model system for studying centromeres and kinetochores, as its kinetochores, the smallest known, represent the organizational module that, through repeated units, form larger kinetochores like those found in humans. In CENStruK, I will combine my background and expertise in yeast genetics and cell biology with the host lab’s expertise in mechanistic biochemistry, its large collection of proteins involved chromosome segregation, and its advanced electron microscopy facilities to fill this gap. CENStruK is divided into two complementary structural approaches. First, by harnessing required protein chaperones, I will reconstitute a key step in yeast’s inner kinetochore assembly that is required for recognition of its native centromere sequence. Second, I will deploy the ‘CentiCEN’ strain, which houses over 100 homogenized centromeres. This strain will be used in parallel for biophysical and structural studies of the endogenous CEN-kinetochore complex using cryo-EM and cryo-ET. My studies will not only shed light on a fundamental unknown in chromosome biology but will also inform future work in diverse eukaryotic species.

Keywords: centromere,kinetochore,cell division,saccharomyces,cas12
Overcoming limits for pre-clinical small volume liquid delivery into skin and inflammation quantification (Lab-In-Skin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Chronic inflammatory skin diseases have a huge burden on patients, their families, and the economy. New patient-friendly delivery methods are urgently needed targeting immune cells in the dermis. Injecting small volumes of biologics directly in skin lesions using needle-free technology would revolutionize treatments and shift the systemic dosing paradigm to individualized local dosing. However, to realize this vision, there is a long path to test its effectiveness in pre-clinical (in vitro, ex vivo) and clinical studies. First, testing new drugs is costly and often involves tests with animals with poor translational value because of differences in skin anatomy with humans. Therefore, with this project, we will establish the proof of concept that BuBble Gun, a minimal invasive injection method can effectively be used for innovative drug testing via Skin-On-Chip technology. We will study in vitro skin inflammation response with plasma activated water and active pharmaceutic ingredients used in treating skin diseases such as eczema (atopic dermatitis) and psoriasis. Lastly, in collaboration with several stakeholders, we will prepare a business plan to clear the way for further developments and establish the best path to revolutionize drug delivery into skin and cosmetics.
Imprinting and clonality of human NK cell memory (MEM-CLONK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2372750.0
EU funding (EUR): 2372750.0
Participants: 2
Project status: SIGNED

The pool of innate immune effector cells is wired to rapidly respond to pathogens, whereas only few specificities within the naïve adaptive repertoire expand clonally, undergo epigenetic remodelling and differentiate into effector and memory cells. However, innate cells can differentiate upon pathogen encounter and remember past experiences as well, thereby challenging this strict dichotomy. In particular, us and others have shown that human memory Natural Killer (NK) cells with global epigenetic remodelling can be generated in response to specific signals during cytomegalovirus (CMV) infection. We have recently identified two major types of open chromatin domains in human memory NK (mNK) cells ex vivo: first, a shared signature featured by all mNK cells across CMV-seropositive donors (“public memory”); second, a diverse set of unique open chromatin regions associated with the drastic expansions of individual and stable NK cell clones (“private memory”). Based on this unexpected finding, we hypothesise that the shared and the unique clonal memory might provide mNK cells with increased fitness and high effector potential, but also enhance the risk of oncogenic mutations. The ultimate goal of this project is to identify the signals and molecular mechanisms driving acquisition, selection and maintenance of human NK cell public and private clonal memory. To this end, we will combine multiomic single cell assays and lineage tracing of human NK cells from healthy donors and patients ex vivo, or under various stimuli in vitro, with genome-wide CRISPR perturbation studies to directly link ex vivo features with functional read outs. Success of this project will not only lead to new insights into the key networks promoting persistence and effector functions of mNK cells, but also reveal promising novel targets for cellular anti-tumour therapies.
SPINTOP (SPINTOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

There exists a class of important computational problems that conventional computers are unable to address with reasonable efficiency. Such Combinatorial Optimization (CO) problems are pervasive in a wide range of critically important sectors of society, e.g. in business operations, manufacturing, and research, including man-power scheduling, vehicle routing, IC circuit layout, protein folding and DNA sequencing, efficient big-data clustering, election modelling, network diagnosis, modelling molecular dynamics, discovery of new medicines/chemicals/materials, and so forth. At present, the CO market size is of the order of €1B and is expected to exhibit a 56% market growth rate with a 2030 market size forecast at €50B. Since conventional computers are ineffective in handling large CO problems, dedicated hardware – both quantum and quantum-inspired – are intensely researched and developed world-wide. A quantum-inspired alternative – so-called Ising Machines – has been developed over the last 20 years by D-wave in superconducting technology and is commercially available. However, being a superconducting technology, it suffers from operation at 20 mK requiring 25 kW of cooling power, little hope for much miniaturization of the complete system (today about 30 m3), and extreme cost (~10 M$ per system). Clearly, there is a need for a fast, scalable, energy-efficient, and affordable Ising Machine in dedicated hardware, without any of the severe drawbacks of the D-wave technology. This is the problem that SPINTOP wants to address. SPINTOP will deliver fast, scalable, energy-efficient and affordable Ising Machines based on networks of spin Hall nano-oscillators (SHNOs) pioneered by the applicant (JÅ) in his ongoing ERC Adv. Grant TOPSPIN. The proposed technology has tremendous breakthrough innovation potential and will aid in solving societal challenges related to almost all UN Sustainable Development Goals.
FuEl ThE bRaiN In healtThY aging and agE-relateD diseases (ETERNITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,France,Germany,Spain,Belgium,Switzerland
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2660276.57
EU funding (EUR): 2629260.0
Participants: 15
Project status: SIGNED

The worldwide population is ageing and putting our healthcare systems under pressure to cope with age-related diseases. In Europe, there is a need for innovation, knowledge and experts who can prompt significant changes to improve prevention and innovative interventional strategies to counteract altered metabolism in brain during ageing and related disorders. The priority is to ensure brain health throughout life and during ageing. Increased collaboration between academia and private sector is the required milieu to overcome this challenge. The “FuEl ThE bRaiN In healtThY aging and agE-relateD diseases” ETERNITY will contribute to the strengthening of the European innovation capacity by training a new generation of researchers with experience and full understanding of the requirements of academia, pharmaceutical and food supplement companies, and the society. ETERNITY research programme will focus on brain metabolism as a highly promising yet under-explored area. Given the complementary expertise, ETERNITY will have excellent opportunities to delineate different pathways underlying impaired brain metabolism to identify novel pharmaceutical targets and/or nutritional interventional strategies to counteract ageing and related disorders. The early-stage researchers (DCs) will be trained in this environment and provided with a mind-set of future commercial and clinical utilization of their research findings. Apart from the innovative and collaborative approach of the research programme, the DCs will also be provided with a training programme where cutting-edge methodology, innovation and transferable skills are key components. The trained DCs will have excellent intersectoral and interdisciplinary career opportunities and will, together with the ETERNITY partners, provide a solid ground to tackle one of the major societal challenges of our century: finding therapies to promote brain healthy ageing and delay the onset of neurodegenerative diseases.

Keywords: energy metabolism,brain,animals models,cellular models,obesity,neurodegenarion,ageing