Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding gene regulation in nuclear space (Hotspot)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1994500.0
EU funding (EUR): 1994500.0
Participants: 1
Project status: SIGNED

There is accumulating evidence for a new gene expression paradigm, in which genes and transcription factors cooperate to create specialized nuclear hotspots optimized for transcription. How hotspots form, and how they impact transcription, however, is unclear. This is mostly because mechanistic and functional approaches have been limited by the large number of hotspots per nucleus, their small size, and their transient nature. Here, wThere is accumulating evidence for a new gene expression paradigm, in which genes and transcription factors cooperate to create specialized nuclear hotspots optimized for transcription. How hotspots form, and how they impact transcription, however, is unclear. This is mostly because mechanistic and functional approaches have been limited by the large number of hotspots per nucleus, their small size, and their transient nature. Here, we will take advantage of two hotspots that precede all other transcription during zebrafish embryogenesis. The hotspots are large, isolated, and relatively long-lived, and we can interfere with their formation specifically. They therefore provide an excellent opportunity to study nuclear hotspots. The stereotyped activation of transcription during embryogenesis further provides the opportunity to determine the effect of hotspots on gene expression. In Aim 1, we will determine what triggers hotspot formation, identify the components of hotspots and the order in which they come together, and determine the enrichment of components in hotspots compared to nucleoplasm. In Aim 2, we turn our attention to the genes that come together in these hotspots. We will develop a method to visualize single copy genes live and use this to determine how genes come together in transcription hotspots to be activated. Together, the work we propose will reveal how stable gene expression programs can emerge from the self- organizing interactions between chromatin, transcription factors and emergent properties of transcribed sites.

Keywords: nuclear organization,transcription,phase separation
Smart Grids Energy management Staff (SMART GEMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Italy,Spain,Italy,Cyprus,Singapore,Greece,Lithuania,Greece,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-09-01
End date: 2020-02-29
Duration (months): 54.0
Total project cost (EUR): 1012500.0
EU funding (EUR): 958500.0
Participants: 13
Project status: CLOSED

Smart grid is a dynamically interactive real-time infrastructure concept that encompasses the many visions of diverse energy system stakeholders. The Smart Grid is integrating the electrical and information technologies in between any point of generation and any point of consumption. The main objective of the project is to fully analyze all aspects of smart grids targeting in the improvement of reliability, mitigation of security risks, increase load shaping and energy efficiency, optimal integration and generation-consumption matching as well as smart monitoring and control. To this end, the aim of the SMART GEMS project is to use Smart Grids’ optimization and reliable operation concept as the common basis for collaboration and staff exchange among the partners. The overall effort will be based in two existing smart grid infrastructures owned by TUC and AEA and is designed to exploit the complementary expertise of the participants as well as enhance and create more synergies. Moreover the infrastructure of all partners will be available for the project’s goals. In this framework, SMART-GEMS partners are selected to formulate a complementary group which encompasses all the major aspects of smart grids. During the SMART GEMS secondments, a mixture of research and training will be blended in a suitable proportion as to maximize the career perspectives of the researchers involved focusing on innovation skills related to smart grids and smart communities interdisciplinary aspects. The methodological approach is designed to enhance the researchers’ competitiveness and promote the ideas sharing from research to market and vice versa. The methodology is based on a cycle expansion in three dimensions where all participants are actively involved

Keywords: smart grids,smart cities urban engineering,zero energy buildings,zero energy communities
Hybrid cooling system for semiconductor detectors of X- and Gamma- Rays (SEMICOOL-H)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Latvia
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Semiconductor detectors for x- and gamma-rays registration are widely used in nuclear energetic and ecology, geology and mineral resource industry, medicine and scientific research activities, other spheres. To provide the best performance in all applications, HPGe and SiLi detectors require a cooling till liquid nitrogen (LN2) temperatures. In general cooling system semiconductor detectors are installed in vacuum cryostat which is submerced to Dewar vessel with LN2. In the process of using LN2 there is constant boiling and evaporating of LN2 and therefore there is a permanent necessity to control a LN2 level in Dewar vessel and to fill it with the certain periodicity. Typical periodicity for 20-30 l volume change is once per week. Refilling these volumes is problematic due to its need for permanent attention and that automatic filling requires special expensive equipment. This proposal declares a technology where refilling of LN2 is needed with much lower periodicity (about once in a year). This hybrid cooling system includes cryostat with semiconductor detector, Dewar vessel with LN2 for detector cooling and electrical cooler for condensation of evaporated LN2. Such system should be hermetically closed. The current system provides the re-use of resources (LN2) so giving the contribution in the sustainability of resources and energy efficiency. The following project realizes the feasibility study for the development of advanced hybrid cooling system for semiconductor detectors.

Keywords: energy efficiency
Hybrid Optomechanical Technologies (HOT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Italy,Germany,Malta,Belgium,Finland,Switzerland,Switzerland,France,France,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: FET Proactive: emerging themes and communities (FETPROACT-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 19
Project status: CLOSED

The hybrid optomechanical technologies (HOT) consortium will lay the foundation for a new generation of devices, which connect, or indeed contain, several platforms at the nanoscale in a single “hybrid” system. As hybrid interfaces they will allow to harness the unique advantages of each subsystem within a nano-scale footprint, while as integrated hybrid devices they will enable entirely novel functionalities. A particular focus will be on nano-optomechanical devices that comprise electrical, microwave or optical systems with micro- and nano-mechanical systems. Research in the past decade, in particular by European groups, has shown the significant technological potential that such nano-optomechanical systems can offer, in particular by establishing a new way in which optical, radio-frequency and microwave signals can be interfaced. The present consortium includes leading academic groups and industrial partners to explore the potential of these hybrid-nano-optomechanical systems. It will explore hybrid opto- and electro-mechanical devices operating at the physical limit for conversion, synthesis, processing, sensing and measurement of EM fields, comprising radio, microwave frequencies to the terahertz domain. These spectral domains open realistic applications in the existing application domains of medical (e.g. MRI imaging), security (e.g. Radar and THz monitoring), positioning, timing and navigations (Oscillators) and for future quantum technology. The research aims at specific technological application, with realistic operating conditions and seeks to develop actual system demonstrators. In addition, it will explore how these hybrid transducers can be fabricated within standard CMOS processing, and thereby be made compatible with current manufacturing methods. The HOT devices will thereby impact today’s technology and likewise address potential future need for the manipulation of quantum signals.
Training a new breed of interdisciplinary researchers to respond to the opportunities and challenges of ageing (NEWBREED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Sweden
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-09-01
End date: 2024-08-31
Duration (months): 84.0
Total project cost (EUR): 2511360.0
EU funding (EUR): 1255680.0
Participants: 1
Project status: SIGNED

The ageing population is one of Europe’s and the world’s grand challenges for the 21st century. How to cope with populations that are living ever longer and understanding the processes and means of tackling and benefitting from such populations has already been studied in great detail. However, the studies have mostly been independent, in often almost unrelated areas. To look at ageing throughout the whole life-course from many different dimensions, and not just in elderly people, requires a new breed of interdisciplinary research who has been trained to work on the topic within a number of different disciplines within science and the humanities. NEWBREED will address this challenge through an interdisciplinary doctoral programme, developed and coordinated by Örebro University in Sweden, in cooperation with a network of hosting organisations. These organisation nodes will open up a large network of other organisations for secondments – academic, industries, NGOs, public sector etc. NEWBREED seeks to attract 16 ESRs from Europe and the rest of the world to undertake this interdisciplinary research training. We believe that the NEWBREED programme will provide just that new breed of researcher. Örebro University is especially qualified to run NEWBREED. The programme docks in well with one of the university’s new strategic areas, namely Food and Health and that there is an existing local doctoral programme within Successful Ageing, which has acted as a pilot. In addition, the university has been involved in many age-related EU projects. The programme is divided into four themes: Ageing and psychosocial adjustment, Ageing from a societal perspective, Ageing and the fourth industrial revolution, and The biology of ageing. We believe that the graduated doctoral students will have unique possibilities on the job market with their interdisciplinary and intersectoral experience and can provide especially interesting perspectives into this important field of research.

Keywords: ageing,life course,interdisciplinary,intersectoral,activity,food,nutrition,intergeneration,psychosocial adjustment,big data,health care,retirement
Recombination in large genome crop plants (SHUFFLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-01-31
Duration (months): 64.0
Total project cost (EUR): 2499980.0
EU funding (EUR): 2499980.0
Participants: 1
Project status: CLOSED

During meiosis, recombination (crossing-over, CO) drives the exchange of genetic materials and releases genetic diversity by creating new combinations of alleles within and among chromosomes. CO is exploited in plant breeding through the generation of large populations of recombinants from which genetically improved individuals are selected. However in some economically important crops such as barley, the rate of improvement has plateaued. One hypothesis is that this is due to constraints on the locations of CO. In large genome cereals CO is restricted to the ends of chromosomes, excluding approximately two thirds of the genome from the breeding process. This project focuses on three critically important questions about CO in barley: Why is it restricted to the telomeric ends of chromosomes? What proteins are the key players and what are their roles in controlling CO? And, what strategies can be established to effectively increase or redistribute CO in CO-poor regions? I will address these questions in four Work Packages. In WP1 I will induce, identify and molecularly characterise putative meiotic mutants both phenotypically (at the plant level) and molecularly by captured exome sequencing. In WP2 I will characterise these mutants cytologically, genetically and by complementation to understand how the mutations affect recombination. In WPs 3 and 4, I will apply novel methods to isolate the specific cells undergoing meiosis, and use transcriptomics, targeted proteomics and pull-down assays to investigate how meiosis is regulated. I will focus on complexes that mark the sites of DNA double strand break (DSB) formation that identify where CO will occur. I will characterise these sites according to those resolved as either crossing-over or non-crossing-over events and relate their physical location to COs observed in population genetic data. Finally, I will evaluate strategies for modifying the distribution of recombination, and application in plant breeding
Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials (caLIBRAte)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,South Africa,Germany,Spain,Spain,Belgium,Switzerland,Finland,Finland,Sweden,Finland,France,United States,Netherlands,Netherlands,Denmark,United Kingdom,Denmark
Call: Next generation tools for risk governance of nanomaterials (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-05-01
End date: 2019-10-31
Duration (months): 42.0
Total project cost (EUR): 9828106.25
EU funding (EUR): 7999687.5
Participants: 26
Project status: CLOSED

The objective of the caLIBRAte project is to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. The framework will be a web-based “system-of-systems” linking different models and methods for: 1) screening of apparent and perceived risks and trends in nanotechnology, 2) control banding, qualitative and fully integrated predictive quantitative risk assessment operational at different information levels, 3) safety-by-design and multi-criteria decision support methods, 4) risk surveillance, -management and -guidance documents. The risk management framework will support assessments of emerging and existing MN and MN-enabled products following the recent ISO31000 risk governance framework, as well as safety in innovation by matching models to the principle innovation steps in the “Cooper Stage-Gate®” product innovation model Control banding tools and quantitative models will be subject to sensitivity analysis and performance testing followed by a revision as needed. After revision the models will again be analyzed by sensitivity testing, calibration, performance tested to establish the uncertainties. After calibration, the models will be part of the framework, which will be demonstrated by case studies. Stakeholders will be involved for defining the user requirements of the framework and will receive training in the framework at the end. The caLIBRAte project proposal answers to the call of NMP30-2015: Next generation tools for risk governance of MNs. The project is specifically designed to address the key challenges defined in the scope of the call text. There is particular focus on model revision, calibration and demonstration of existing models and methods that support the risk governance framework in regards to safe innovation and already implemented nanomaterials. Next generation computational exposure assessment and -toxicology is anticipated in the framework

Keywords: nanomaterials,risk governance,risk assessment,control banding,decision support,integrated risk assessment,hazard prediction,computational toxicology,exposure modelling,web tool
Composition of solar system small bodies (SOLARYS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 2421180.0
EU funding (EUR): 2421180.0
Participants: 2
Project status: SIGNED

The small bodies population (comets, asteroids, KBOs) is today central to Solar System studies. These objects are used to reconstruct the dynamical scenarios of Solar System formation and evolution, and are expected to have played a key role in the habitability of terrestrial planets. Because they are rich in volatile and organics, comets and dark asteroid types (C-, D-) are under intense scrutiny by the Planetary Science community. The objective of this project is to determine the composition of these primitive small bodies and whether or not we have samples available from their surfaces in the form of meteorites and extra-terrestrial dusts (IDPs, micrometeorites). Several decades of research have focused on comparing meteorites laboratory spectra to small bodies observations to decipher composition. The originality of my approach will be to focus on determining the optical properties of extra-terrestrial dusts and confront with already available observations of the small bodies populations. Since available dusts are tiny particles, they are not optically thick, and it is not possible to determine directly the optical signature of a surface covered by such material. My approach will be first to characterize the constituents of IDPs, micrometeorites and meteorites matrices, with groundbreaking infrared spectroscopy techniques. Using AFM-IR, I will be able to characterize at the 50 nm scale the nature of the individual constituents of each particle in situ (organic and mineral), without destroying the textural relation between components. From there, I will have an understanding of the grain structure and composition, which I will use to prepare an optically thick analogue made of sub-µm particles and characterize its optical properties. Last, I will confront these results to small bodies observations, in order to search for possible parent bodies, providing somehow a sample return mission without the cost of a space mission.
Remote long-term monitoring of critical infrastructure with key safety movement band tolerance in landslide vulnerable areas (ALARTE)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Spain,Belgium,Türkiye,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2020-11-01
End date: 2023-12-31
Duration (months): 38.0
Total project cost (EUR): 2512228.75
EU funding (EUR): 2039735.13
Participants: 5
Project status: SIGNED

Monitoring slope movements is becoming a crucial task in today’s societies. Natural landslides cause damages of €18 billion/year at a global scale, and around 66M people—1% of the world’s population—currently live in high-risk areas. Furthermore, this number is increasing steadily due to climate change. On the other hand, human activities such as large geotechnical constructions, a growing network of linear infrastructures and mining increase the danger of soil movement. The need for cost-effective and reliable slope monitoring technology is increasing. However, currently available slope monitoring technologies are basically reduced to manual inclinometer probes, which require the deployment of operators and equipment to take measures directly in the slope. This hampers measurements at short intervals or in remote or unstable areas. Automatic inclinometers are capable of transmitting data in real time, however they are very costly and require complex technical installations. We present ALARTE: an automatic inclinometer probe that can transmit data in real, is cost-effective and easily installed; a game-changing technology that will disrupt the market of geotechnical monitoring by closing the gap between manual and automatic monitoring options. The consortium is composed by companies covering the whole supply chain: Tecnalia (Spain), IPR and R&D, Mikrosay (Turkey) production, FEHRL (Belgium) dissemination, Sixense (France) commercialization and Ferrovial (Spain) validation. We will target monitoring service companies, geotechnical consultants, critical infrastructure operators, and the Public administration putting the focus on growing infrastructure markets: linear, energy, mining and urban engineering. We plan sale at least 3,078 ALARTE units and sign 574 monitoring service contracts. Thanks to this strategy, the project will generate €31.35 M in revenues by the fifth year of commercialization (€11.6 M cumulative profit), ROI 4.6 against total investment of €2.51 M

Keywords: geotechnical instrumentation,slope monitoring,landslides,mitigation actions,climate change,deep ground monitoring,critical infrastructure