Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developmental and Genetic Analysis of DNA Double-Strand Break Repair (DSBREPAIR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Netherlands,Netherlands
Call:  (ERC-2007-StG, 2007)
Start date: 2008-05-01
End date: 2014-04-30
Duration (months): 72.0
Total project cost (EUR): 1060000.0
EU funding (EUR): 1060000.0
Participants: 2
Project status: CLOSED

The DNA within our cells is constantly being damaged by both environmental and endogenous agents; of the many forms of DNA damage, the DNA double-strand break (DSB) is considered to be most dangerous. Correct processing of DSBs is not only essential for maintaining genomic integrity but is also required in specific biological processes, such as meiotic recombination and V(D)J recombination, in which DNA breaks are deliberately generated. In animals, defects in the proper response to DSBs can thus have different outcomes: cancer predisposition, embryonic lethality, or compromised immunity. Many genes that play a role in the processing of DSBs have been identified over the past decades, mainly by cloning genes that are responsible for specific human genomic instability or immune deficiency syndromes, and by genetic approaches using unicellular eukaryotes and rodent cell lines. It is, however, evident that many components required in higher eukaryotes are not yet known and the identification of those will be a major challenge for future research. Here, we will for the first time systematically test all genes encoded by an animals genome directly for their involvement in the cellular response to DSB in both somatic and germline tissues: we will use our recently developed transgenic animal models (C. elegans) that visualizes repair of a single localized genomic DNA break in genome wide RNAi screenings to identify (and then characterize) the complement of genes that are required to keep our genome stable, and when mutated can predispose humans to cancer. In parallel, we will study the cellular response to single DNA breaks that are artificially generated during different stages of gametogenesis, as well as address the developmental consequences of DSB induction during the earliest stages of embryonic development – an almost completely unexplored area in the field of genome instability and DNA damage responses.

Keywords: dna double-strand breaks,dna damage responses,genomic instability
Shifting the oligomerization equilibrium of proteins: a novel therapeutic strategy (SHIFTIDES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Israel
Call:  (ERC-2007-StG, 2007)
Start date: 2008-07-01
End date: 2013-06-30
Duration (months): 60.0
Total project cost (EUR): 1250000.0
EU funding (EUR): 1250000.0
Participants: 1
Project status: CLOSED

The aim of my project is to establish a multidisciplinary platform for quantitative biophysical analysis of protein-protein interactions in health and disease as a basis for drug design: (1) Analyzing protein-protein interactions at the molecular level in healthy systems; (2) Understanding what goes wrong in disease at the molecular level; (3) Development of drugs that will restore the biological system to its healthy conditions. My team will apply this approach to establish the concept of shifting the oligomerization equilibrium of proteins as a therapeutic strategy. I will expand the concepts of allosteric inhibitors and chemical chaperones, and develop the “shiftides”: peptides that shift the oligomerization equilibrium of a protein to modulate its activity, as a new and widely applicable methodology for drug design. I will apply this concept for: (1) inhibiting a protein by binding preferentially to the inactive oligomeric state and shifting the oligomerization equilibrium of the protein towards it; I have demonstrated the feasibility of this approach and developed promising anti-HIV peptides that inhibit the HIV-1 integrase and consequently HIV-1 replication in cells by shifting the integrase oligomerization equilibrium from the active dimer to the inactive tetramer. My team will further develop these peptides, and apply the same approach to inhibit the HIV proteins reverse transcriptase and protease; (2) Activating a protein by binding preferentially to the active oligomeric state and shifting the oligomerization equilibrium towards it: This will be applied for activation of the tumor suppressor p53, by shifting its oligomerization equilibrium from the inactive dimer to the active tetramer. Such shiftides will serve as anti-cancer lead compounds. My project will open new doors in the field of drug design, and at the end of the five-year period will result in a general new methodology to affect protein function for medical purposes.

Keywords: drug design,biophysics,protein,aids,cancer,oligomerization
Synchronous Linguistic and Visual Processing (SYNPROC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Environment and society
Countries involved: United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2014-08-31
Duration (months): 72.0
Total project cost (EUR): 1126000.0
EU funding (EUR): 1126000.0
Participants: 1
Project status: CLOSED

When humans process language, they rarely do so in isolation. Linguistic input often occurs synchronously with visual input, e.g., in everyday activities such as attending a lecture or following directions on a map. The visual context constrains the interpretation of the linguistic input, and vice versa, making processing more efficient and less ambiguous. Given the ubiquity of synchronous linguistic and visual processing, it is surprising that there is only a sparse experimental literature that deals with this topic, while virtually no computational models exist that capture the synchronous interpretation process. We propose an experimental research program that will investigate key features of synchronous processing by tracking participants' eye movements when they view a naturalistic scene and listen to a speech stimulus at the same time. The aim is to understand synchronous processing better by studying the interaction of saliency and ambiguity, and the role of incrementality, object context, and task factors. These experimental results will feed into a series of computational models that predict the eye-movement patterns that humans exhibit when they view a scene and listen to speech at the same time. The key modeling idea is to treat synchronous processing as an alignment problem, for which a rich literature exists in computational linguistics. Building on this literature, we will develop models that incrementally construct aligned linguistic and visual representations, and that can be evaluated against eye-tracking data.

Keywords: language processing,visual processing,eye-tracking,cognitive modeling,probabilistic models,computational linguistics,alignment,synchronous grammars
Quantum gases of ultracold polar molecules (QUPOL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Italy
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-07-31
Duration (months): 60.0
Total project cost (EUR): 1230000.0
EU funding (EUR): 1230000.0
Participants: 1
Project status: CLOSED

I propose to realize quantum gases of ultracold molecules with a permanent electric dipole moment. This project aims at a significant extension of the field of ultracold quantum gases towards more complex particles interacting via long-range, anisotropic interactions. Quantum gases of polar molecules would allow to study novel kinds of matter waves, to solve open questions in modern condensed matter physics, to explore novel quantum phases and to implement novel quantum computing schemes. Weakly bound heteronuclear dimers formed in ultracold atomic quantum mixtures via magnetic Feshbach resonances will be coherently transferred to deeply-bound ro-vibrational states using laser fields. The formation of both bosonic and fermionic molecules will be explored in different alkali mixtures. The high degree of coherence of the molecular quantum gases will allow to prepare them in selected rotational states of the absolute ground electronic and vibrational state. The molecular electric dipoles will be manipulated via electric and microwave fields. The precise dynamical control of the shape and strength of the dipole-dipole potential will allow to engineer a variety of quantum states and to study many interdisciplinary phenomena. The following themes will be explored: phenomenology of dipolar quantum gases, lattice spin models, polar molecules as qubits.

Keywords: quantum computing,quantum gases
Complex Molecular-scale Systems for NanoElectronics and NanoPlasmonics (COMOSYEL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-12-31
Duration (months): 65.0
Total project cost (EUR): 1439712.0
EU funding (EUR): 1439712.0
Participants: 1
Project status: CLOSED

COMOSYEL aims at designing complex nanometric and molecular systems to process electronic or optical information from the macroscopic to the molecular scale. It proposes two specific, unconventional approaches to molecular electronics and plasmonics and the development of two multidisciplinary technical toolkits, one in bio-inspired chemistry and one in surface nanopatterning by liquid nanodispensing that will support the first two topics, and eventually become a part of the team's culture for future research developments. (1) Graphene-based nanoelectronics is an experimental implementation of mono-molecular electronics concept using graphene to bridge the macroscopic world to the molecular scale. This topic aims at encoding and processing electronic information in a single complex molecular system in order to achieve complex logic functions. (2) Self-assembled nanoplasmonics aims at developing a molecular plasmonics concept. Here, complex networks of sub-20nm crystalline metallic nanoparticle chains are produced and interfaced to convert photons to plasmons and ultimately confine, enhance and route light energy from a conventional light source to an arbitrary chromophore on a substrate. (3) Bio-inspired nanomaterials chemistry will be the main synthetic tool to produce new multifunctional nanostructured materials able to address and collect information from/to the macroscopic world to/from the single molecule level. Both morphogenesis and self-assembly will be explored to better control size and shape of nano-objects and the topology of higher-order architectures. (4) Liquid nanodispensing is a promising tool to interface nanosized/molecular sized systems with both lithographically produced host structures and individual molecular systems. A nanoscale liquid dispensing technique derived from AFM combines resolution and versatility and will be pushed to its extreme to master the deposition of nanoobjects onto a substrate or a precise modification of surfaces.

Keywords: molecular architecture,plasmonics,nanowetting,surface physical chemistry,graphene,bio-inspired nanomaterials chemistry
In vivo imaging of functional plasticity in the mammalian brain (BRAINPLASTICITY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Israel
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-07-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: CLOSED

The dynamic nature of the brain operates at disparate time scales ranging from milliseconds to months. How do single neurons change over such long time scales? This question remains stubborn to answer in the field of brain plasticity mainly because of limited tools to study the physiology of single neurons over time in the complex environment of the brain. The research aim of this proposal is to reveal the physiological changes of single neurons in the mammalian brain over disparate time scales using time-lapse optical imaging. Specifically, we aim to establish a new team that will develop genetic and optical tools to probe the physiological activity of single neurons, in vivo. As a model system, we will study a unique neuronal population in the mammalian brain; the adult-born local neurons in the olfactory bulb. These neurons have tremendous potential to reveal how neurons develop and maintain in the intact brain because they are accessible both genetically and optically. By following the behavior of adult-born neurons in vivo we will discover how neurons mature and maintain over days and weeks. If our objectives will be met, this study has the potential to significantly "raise the bar" on how neuronal plasticity is studied and reveal some basic secrets of the ever changing mammalian brain.

Keywords: plasticity,olfaction
Sharka Containment (SHARCO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: France,Bulgaria,Romania,Spain,Italy,Spain,Poland,Türkiye,Czechia,Germany,Czechia,Slovakia,Serbia,Bulgaria,Romania
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-03-01
End date: 2012-08-31
Duration (months): 54.0
Total project cost (EUR): 3823038.8
EU funding (EUR): 2935674.0
Participants: 16
Project status: CLOSED

SharCo is aimed at helping the EU face the accession of Member States known as endemic of sharka disease by providing the EU with tools such as marker-assisted selection, PPV resistant plant materials, guidelines, warning systems, decision-support system. On that purpose, the project will, in the field of epidemiology, identify driving factors of PPV spread and diversification and develop novel and highthrough-put detection systems warning sharka outbreaks. In the field of genetics, it will provide molecular markers for the implementation of marker assisted selection of PPV resistant fruit varieties. In the field of biology, we will assess innovative biotechnological approaches to broaden resistance to PPV in different fruit tree species. Finally, in order to develop a PPV outbreak management, we will elaborate i) guidelines for endusers and policy makers concerning cultivation and risk management, ii) an early warning system coupled with a decision support system. All knowledge and tools developed by the project will be widely disseminated all over Europe with special attention made to PPV endemic countries.

Keywords: sharka. ppv. epidemiology. genetics. resistance. marker-assisted selection. guidelines. warning systems. decision-support system.
The effects of agronomic practices conducive to organic agriculture on the diversity and function of arbuscular mycorrhizal fungi (ECOMYCORRHIZA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-10-01
End date: 2010-09-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Arbuscular mycorrhizal fungi (AMF) extensively form symbiotic relations with most plants which in most cases result in benefits to the plant including improved nutrition, amelioration of drought stress, improved soil structure, and protection from soil pathogens. AMF are considered key microbial players in low-input agricultural systems like organic farms. Selected efficient AMF could be used as soil inoculum in organic agriculture to benefit plant growth. Crop protection in such organic farms relies on pesticides of biological origin like azadirachtin or Quillaja saponaria, the use of non-chemical soil disinfection methods like soil solarization or biofumigation. The application of by-products of local agricultural industry like olive mill wastewaters (OMWs) might suppress soil plant pathogens and/or improve soil fertility. Although all the above practices are conducive or already used in organic farms there are no data regarding their effects on AMF and fungal community. The current proposal aims to investigate possible effects of crop protection and fertilization practices, conducive to organic farming fundamentals on the community and activity of AMF and other soil fungi. An initial survey will investigate the AMF status, diversity and function in organic farms. Selected AMF from the initial survey will be propagated at pure cultures and community cultures in order to be used in further experiments. Subsequent pot experiments will provide initial evidence of possible effects of the previously mentioned agronomic practices on the function and activity of AMF and fungi. Pot experiment results will be verified at replicated field experiments which allow the evaluation of the effects of these practices under realistic conditions. The proposed project will facilitate the integration of the applicant in EU, provide scientific expertise on mycorrhizal research for the host institution and guarantee training of the applicant to novel molecular fingerprinting methods.

Keywords: soil biodiversity,soil function,soil ecology,pesticides of biological origin,biofumigation,soil solarization,olive mill waste,organic agriculture,arbuscular mycorrhiza fungi
Renal stem cells: possible role in kidney pathologies and as new theraputic tools (RESCARF)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Italy
Call:  (ERC-2007-StG, 2007)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 820200.0
EU funding (EUR): 820200.0
Participants: 1
Project status: CLOSED

Chronic Kidney Disease (CKD) affects 11% of the adult population and is considered by the WHO as one of the health emergencies of the 21st century. Although cell therapy might be beneficial for CKD, human stem cells that might be used to improve kidney function were so far unknown. Recently, we demonstrated the existence of resident stem cells in the urinary pole of the Bowman’s capsule of adult human kidney and therefore named as adult parietal epithelial multipotent progenitors (APEMP). Injection of APEMP in SCID mice affected by acute renal failure, induced regeneration of tubular structures and reduced morphological and functional kidney damage. More recently, we found that APEMP are highly represented in embryonic kidneys and constitute the common progenitor of tubular cells and podocytes. The first aim of this project is to assess the regenerative properties of APEMP in in vivo models of glomerular injury and their potential use as a novel therapeutic tool to prevent the deterioration of kidney function in chronic renal failure. Second, we will try to identify the mechanisms that regulate the growth, survival, differentiation, and migration of APEMP, which is critical to set up cell therapies of renal injury which should be effective and safe. To this end, the role of different molecular pathways such as Sonic hedgehog, Wnt/beta-catenin, Notch, TGF-beta/BMP and of CXCR4, CXCR7 or CXCR3-B chemokine receptors in the regenerative activity of APEMP will be investigated. Third, to assess whether APEMP directly contribute to kidney regeneration after glomerular or tubular damage, transgenic animals in which APEMP are genetically tagged will be generated. Fourth, by using transgenic animals we will try to understand if an alteration of APEMP growth and/or differentiation is implicated in the pathogenesis of some renal disorders that frequently progress towards end stage renal disease.

Keywords: stem cells,kidney,cell therapy,chemokines,niche,crescentic glomerulonephritis,focal segmental glomerulonephritis
Strengthening the IST Research Capacity of Sofia University (SISTER)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Bulgaria
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-04-01
End date: 2011-09-30
Duration (months): 42.0
Total project cost (EUR): 1200088.4
EU funding (EUR): 1070000.0
Participants: 1
Project status: CLOSED

The Faculty of Mathematics and Informatics (FMI) of Sofia University (SU) has developed in the last decades as a centre of excellence in Bulgaria in Information and Communication Technologies (ICT) research and higher education, where contacts with leading EU research institutions have been established. The main goal of SISTER project is to develop FMI as a Leading Centre in SEE in research, innovation and training in two areas of ICT - Intelligent Content and Semantics, Software and Services. An overall goal of the project is to foster the integration of FMI in the ICT ERA and to contribute to competitiveness and growth of the SEE region and Europe as a whole. In order to achieve the main goal the following project objectives are defined:  to elaborate a strategic framework for FMI future development;  to strengthen the research capacity of FMI by enhancing the human resources capabilities of FMI and research integration with EU partners;  to strengthen the capacity of FMI for business exploitation of academic results and cooperation with industry  to improve the research environment of FMI;  to build a strong long-term collaboration of FMI with leading research organisations and enterprises in EU and in SEE countries;  to make FMI a well-known research and innovation centre in SEE. The project is targeted to support the present research collaboration of FMI in the four ICT strategic areas, where a certain integration into EU research already exists, however, it is still at an early stage and needs to be strengthened for buildinga long-term strategic partnership with leading EU research and industrial organisations.

Keywords: researchers mobility,interdisciplinary skills,software engineering,technology enhanced learning,networked enterprises,intelligent content,knowledge management