Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synaptic activity effects on local protein synthesis and spreading in high resolution (DENDRYTE TRANSLATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Understanding how and where our memory is stored is a long sought-after task. It is accepted that proteins at synapses play a role in capturing and maintaining memory. It is now clear that synapses possess the capacity for local protein synthesis, and that dendritic protein synthesis is required for many forms of long-term synaptic potentiation (LTP) and plasticity. It remains unclear over what spatial scale local translation can be regulated and stimulated. Moreover, the location of specific translation sites and the mechanisms by which local dendritic translation is activated are largely unknown. This study aims to determine the effect of single spine activity on local protein synthesis, and to decipher how varying levels of activation of the synapse activity in adjacent spines alters the dynamics and trafficking of newly synthesized proteins and to what extent (spatially and temporally). I will examine the correlation between local translation and the following neurobiological processes: synaptic plasticity, LTP, and the hypothesis of synaptic tagging and capturing. Their activation will be induced using different levels and patterns with high resolution glutamate uncaging, in adjacent or remote spines including on different dendritic branches. I propose to decipher the location of protein synthesis using fluorescent non-canonical amino acid tagging, which allows visualizing the protein synthesis in real time and in its natural site. I will address the translational regulation of exemplar proteins, of which their mRNAs were found to localize in dendrites, that represent neurotransmitter receptors (e.g. GluA1 or 2), scaffolding molecules (e.g. Shank, PSD-95), signaling molecules (e.g. CaMKIIa) and cytoskeletal elements (e.g. b-actin). Understanding the spatial and temporal synthesis of proteins following different levels and patterns of spinal activity will shed light on the mechanisms by which important cell biology processes including LTP and plasticity occur.

Keywords: local translation,protein synthesis,spine,synapse,neurobiology
Reducing the burden of offender mental illness in Europe: improving interorganisational collaboration between the mental health and criminal justice systems (COLLABORATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 312491.6
EU funding (EUR): 312491.6
Participants: 1
Project status: CLOSED

This fellowship enriches international research cooperation between Norway and UK with the long term goal of reducing the social and economic burden of offender mental ill health on the EU. High levels of mental illness in the offender population places financial and logistical burden on European prisons. This is attributable to professionals in mental health (MHS) and criminal justice systems (CJS) not collaborating effectively when offenders present with mental illness. Offender mental health would substantially improve if MHS/CJS professionals were better prepared for collaboration across organizational boundaries. There is currently no pedagogical framework available that supports this training need. The development of such a framework requires interdisciplinary approaches combining knowledge of interprofessional practice (IPP) with knowledge of interprofessional pedagogy. To date, research in interprofessional education (IPE) and IPP have coexisted with little overlap in their activity, meaning that there is a lack of IPE grounded in strong understanding of practice based issues, or substantiated by research into collaborative practice. Similarly, efforts to prepare a collaboratively ready workforce lacks understanding of sound interprofessional learning theory and education methods that better prepare staff for collaborative practice, This project addresses this by bringing together a talented researcher experienced in interprofessional pedagogy together with European leaders in interorganisational integration, collaborative practice and innovation. Their combined skills allow the development of a practice relevant and evidence based pedagogical framework to underpin training that prepares MHS and CJS professionals to work collaboratively in the interest of the mental health of the offender population. This pedagogical framework has transferability to other EU and clinical/welfare contexts where collaborative practice across organisations is required.

Keywords: mental health,criminal justice,offender mental health,interorganisational integration,collaborative practice,interprofessional education,assessment tools,pedagogical framework
Emotional Welfare: From Brotherly Love to Fraternity (EMOWELF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 280965.4
EU funding (EUR): 280965.4
Participants: 1
Project status: CLOSED

The experienced researcher, Dr. David Lederer, seeks secondment to the Australian Research Council Centre of Excellence for the History of the Emotions (outgoing host) for one year. There he will join the Centre at the University of Adelaide, collaborating with the other four hubs in Brisbane, Melbourne, Sydney and Perth. His research on emotional welfare examines sixteenth-century utopian social reform based on brotherly love; its practical implementation by humane/lifesaving societies according to the enlightened doctrine of sympathy; institutionalization by modern nation states as the principle of fraternité (French Revolution); and effects of global transmission by missionaries (case study Australia). Emphasis is on historical development of public health and safety policies and mental health care. He then returns to Queen Mary's University, London (return host) for one year to affect knowledge transfer at the Wellcome Trust Centre of Excellence for the History of the Emotions under Prof. Colin Jones (scientist in charge), with collaborations in Germany and Holland. This transfer includes the experienced researcher’s knowledge of the Australian model for large-scale interdisciplinary project funding in the humanities with multifaceted attention to public impact (public history, museum exhibition and the performing arts). Upon completion, the experienced researcher will have organized one international conference, presenting at others, prepared two articles and co-edited a special issue for publication in peer-reviewed journals, drafted one synthetic monograph, designed a new undergraduate syllabus and a master class, and organized a touring public exhibition. Thereafter, the experienced research will organize an Irish research cluster as PI and prepare a major funding proposal for international collaboration. As career progression, these achievements represent significant milestones toward a posting as full professor at a European research institution.

Keywords: australian aboriginal culture,brotherly love,cognitive psychology,enlightenment,humane society,moral treatment,philanthropy,pietism,psychiatry,reformation,quakers,suicide,sympathy,utopia
Novel Flexible Sheet Forming for High Value Manufacturing (FLEXFORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Developing environmental friendly & sustainable manufacturing technologies has become a driving force to maximise resource efficiency, to reduce energy consumption & environmental pollution. In addition, with ever increasing global competition, it is crucially important for European manufacturers & SMEs to develop core competence of future advanced manufacturing technologies. This IIF project proposes the development of a new flexible sheet forming process to support sustainable technologies of rapid manufacturing high value-added, small batch & customised sheet metal parts, with reduced costs & lead time. The project will support an experienced researcher, Dr Bin Lu, of Shanghai Jiao Tong University (SJTU) China to visit the Department of Mechanical Engineering of the University of Sheffield (USFD) UK for 24 months. Bringing his unique knowledge & expertise in the flexible sheet metal forming technologies and skills in numerical modelling & optimisation techniques, Dr Lu will be focusing on the development of a new concept of Laser Assisted Double Side Incremental Forming using WaterJet (DSIF-LWJ), design of a bespoke prototype machine & manufacture of three sheet metal parts for industrial demonstration. The project will benefit from transfer of knowledge to the host USFD in fundamental research of combined effects of laser & waterjet on material plastic deformation as well as advanced flexible sheet forming, hybrid process control & system integration technologies. By demonstrating scientific advances & economic potentials of the flexible sheet forming of DSIF-LWJ, the project will not only enable the share of the candidate’s knowledge & expertise, develop long-term collaborations, but also make a contribution to help European manufacturers & SMEs enhance their technical capabilities & overall competitiveness in high value added & user driven production therefore strengthen the EU’s competitive position to meet future challenges of sustainable manufacturing.

Keywords: flexible forming,incremental forming,waterjet,laser
The Role of ASY1 in Promoting Meiotic Stability in Polyploid Arabidopsis (POLYMEIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 279780.9
EU funding (EUR): 279780.9
Participants: 1
Project status: CLOSED

Reliable chromosome segregation during cell division is absolutely critical for the survival, health and fertility of eukaryotes. In polyploids, the presence of an additional set of identical (or closely related) chromosomes makes correct segregation particularly difficult and as a result most newly formed polyploids form multivalents at metaphase I and have low fertility. By contrast, natural polyploid populations have usually evolved a highly stable meiosis with strict bivalent formation and high fertility. Recently, ASY1 was confirmed as playing an important role in this “diploidisation” of meiosis in autotetraploid Arabidopsis arenosa. ASY1 is one of several meiotic genes, mainly involved in chromosome synapsis and cohesion, that show signatures of strong selection in tetraploid A. arenosa and has also been implicated in the diploidisation of meiosis in polyploid wheat. The work outlined in this proposal will interrogate our working hypothesis that the tetraploid ASY1 variant promotes meiotic adaption in autotetraploid A. arenosa through a reduction in cross-over frequency, perhaps mediated through increased cross-over interference strength. The proposed research will also determine whether the tetraploid ASY1 variant promotes similar meiotic behaviour in other Arabidopsis species. This research will underpin an understanding of chromosome pairing and segregation that is still lacking in polyploids, and is relevant to a wide range of fields from crop improvement to cancer biology.

Keywords: meiosis,polyploid,arabidopsis,chromosome segregation,recombination,synapsis,arabidopsis arenosa,interference
Identification of the mechanisms of unconventional protein secretion: AP2, a new protein secreted by this unknown pathway (UNPROSEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-15
End date: 2017-05-14
Duration (months): 36.0
Total project cost (EUR): 265263.3
EU funding (EUR): 265263.3
Participants: 1
Project status: CLOSED

Most of the secreted proteins transit into and through the endoplasmic reticulum (ER) and the Golgi apparatus. However, eukaryotic cells secrete a class of proteins, which do not enter the ER. Very little is known about this “unconventional secretory pathway”. The last protein identified to be secreted by this pathway is AP2, a cytoplasmic fatty acid-binding protein, which is secreted unconventionally by adipocytes to control glucose liver metabolism. It was reported that the unconventional secretion of Acb1 from Saccharomyces cerevisiae requires diverse group of proteins including GRASP ortholog Grh1, autophagy-related proteins, proteins involved in fusion of membranes with endosomes, members of the ESCRT-machinery, and the plasma membrane t-SNARE Sso1. The requirement of GRASP and autophagy-related proteins has also been reported to be required for the unconventional secretion of IL-1beta, IL-18 and HMGB1 in mammalian cell. How these proteins work together for the unconventional secretory pathway remains elusive. We hypothesize that this process is mediated by a secretory autophagosome and our goal is to reveal the mechanism of this secretory process. We aim to proof this by assessing three main objectives. First, I aim at identifying new proteins require for AP2 secretion. Second, I aim at characterizing morphologically and biochemically the vesicular intermediates required for AP2 secretion. Third, I aim at isolating vesicular intermediates containing AP2 to identify their polypeptide composition. Our approach should allow us to reveal a number of new proteins involved in the process of unconventional proteins secretion as well as the mechanisms of biogenesis, transport and fusion with the membrane of the vesicular intermediates required for this process. The understanding of the mechanisms involved in AP2 secretion is of fundamental importance and can have a significant impact on the understanding of a wide variety of human metabolic diseases.

Keywords: unconventional protein secretion,protein trafficking,secretory autophagosome,adipocyte fatty acid-binding protein
New directions in market design (NEWDIRMD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-08-01
End date: 2016-07-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

Recent years have seen an increasing use of theoretically grounded market designs to solve important real-life matching problems. A key factor for these practical accomplishments is that matching theory has been successful in developing centralized mechanisms that are (1) stable, that is, give agents no incentive to contract outside the mechanism, and (2) strategy-proof for a significant subset of participants, that is, provide these economic agents with strong incentives to reveal their true preferences over available matching opportunities to the mechanism. This project aims to make significant progress towards solving two of the most important open questions in this research area. First, several high-profile practical applications have shown that there is scope for designing stable and strategy-proof mechanisms even when the weakest known sufficient conditions for the existence of such a mechanism are not satisfied. I aim to provide a complete characterization of the circumstances under which stability and strategy-proofness can be achieved by means of a centralized matching mechanism. Apart from providing a unifying explanation for all existing applications, the hoped for results can help to identify new real-world problems to which matching theory can be applied. Second, full centralization is not feasible for many important real-life matching markets. Decentralized markets often suffer from congestion, which induces strong incentives for participants to condition their behavior on available statistics about past market conditions. In the second part of this project, I plan to study the dynamic consequences of individual learning in decentralized matching markets using theoretical, empirical, and experimental methods. The key motivating application is a decentralized university admission system and my research has the potential to yield practically implementable advice on how to make such an admission process work more efficiently.

Keywords: matching theory,market design,learning,game theory
The Voices of Venice. Anthro-Ecological Perspective on the Making of Medieval Europe. (VOICESOFVENICE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-10
End date: 2017-09-09
Duration (months): 36.0
Total project cost (EUR): 350669.8
EU funding (EUR): 350669.8
Participants: 1
Project status: CLOSED

VoicesOfVenice aims to provide the principal researcher, a landscape archaeologist focused on medieval Europe, with comprehensive training in anthropology and ecology in order to re-write the “Origin of Venice”. The research will stimulate a critical reappraisal of the one of the most well studied European historical and social phenomenon, the birth of the Serenissima. The proposed project will develop a new archaeological viewpoint, including a comprehensive environmental approach, will help to implements innovative methods for re-interpret the formation of the new settlements in the Venetian lagoons between Late Antiquity and Early Middle ages. A unique archaeological dataset, derived from the privileged viewpoint offered by ongoing excavations in Torcello, will form the basis of the project. New theoretical approaches will be developed, informed from new tendencies of the postprocessualist experiences in archaeology and social studies. The project will shift from current model where Material Culture is used to develop historical models, suitable for the explanation of the major past events, to a different material approach. Giving special attention to the physical processes in which the “things” of the past (artefacts, landscapes, technologies) have been exposed, archaeological and environmental data will be interrogate for knowing how ancient and present societies have been entrapped into the maintenance and sustaining of a very specific material world. A significant part of the training will devoted to Public Archaeology, reconsidering how the tale of the “Origins” has been narrated. VoiceOfVenices aims to trace the anthropological perspective of the tale, starting with the review of the medieval chronicles, going on with the contemporary studies, and ending with the narration today, between academia, web and social networks.

Keywords: venice's origins,making medieval europe,anthropology,ecology,archaeology,archaeometry,late antique early midlle age,theory in archaeology
Fungal conservation genetics: species traits and dispersal (FUNDISTRAIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-03
End date: 2016-07-02
Duration (months): 24.0
Total project cost (EUR): 241066.8
EU funding (EUR): 241066.8
Participants: 1
Project status: CLOSED

Wood-decay fungi are essential for the functioning of forest ecosystems: they drive wood decomposition and soil formation in forests. They provide habitat for many other organisms and enable the regeneration of forests throughout the world. But many wood-decay fungi are threatened by forest management, and up to 42% of the species are in national Red Lists. Their occurrence in fragmented forest landscape is limited by ecological, evolution and dispersal traits. In order to address mechanisms responsible for fungal dispersal, this study will focus on determining which species, population and environmental characteristics correlate with dispersal inferred from population genotype patterns throughout a community of fungi. For several ecological and biological reasons, polypore fungi will be studied. To start, a sampling scheme will be design and twelve polypores species will be sampled on each of the six European locations in Norway, Sweden, Finland, Estonia, Northwestern Russia and Ukraine. Four trait categories related to dispersal capacity and survival will be studied: (i) traits that are directly relevant to dispersal, (ii) traits related to spore production, (iii) life history traits and (iv) traits linked to environmental conditions that may impact dispersal and survival. In addition, a new high throughput sequencing technology, Restriction site Associated DNA, will be optimised to investigate genetic diversity in polypore communities. Finally, different hypotheses will be tested in order to determine which traits correlate with genetic diversity within populations and genetic distance among populations. This current project is the first to integrate community, population and genotype-level information which will help to gain a clear picture of fungal dispersal and how it influences biodiversity. Better understanding of the mechanisms will enhance the ability to manage and conserve the biodiversity and functions of fungal communities in forest world-wide.

Keywords: polypore fungi,rad sequencing,fungal biodiversity,dispersal capacities,population genetics,structure and dynamics of fungal populations,mathematical modelling,forest management