Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A framework for individual-based forest landscape modeling under changing climate and disturbance regimes (ILAND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 220857.32
EU funding (EUR): 220857.32
Participants: 1
Project status: CLOSED

Climate change is a major challenge for sustainable forest management. Impacts on the disturbance regime are particularly relevant in this regard. In a sound science-based sustainable forest management/ ecosystem management approach (SFEM) potential changes in climate and disturbance regimes need to be considered explicitly. Disturbance dynamics, however, are still poorly understood especially in ecosystems with interacting, climate-sensitive disturbance agents. Currently, most available model approaches suffer either from a limited spatial extent to address large scale interacting disturbance regimes (i.e. stand models) or a coarse structural resolution with regard to the information needs in resource management (i.e. landscape models). The objective of the proposed research is to bridge this gap in (i) developing an individual-based landscape modeling framework; (ii) adopting process-oriented disturbance modules and utilizing existing ecological understanding to model disturbance interactions, and (iii) testing the model framework in two case studies in the temperate forest biome. To successfully address (interactions between) disturbances as emerging property of the modeled system as well as to provide relevant levels of information in the context of SFEM an individual-based, process-oriented landscape modeling approach is proposed. The development will bring together recent advances in forest landscape modeling with efficient algorithms of modeling individual-based tree competition and process-based production. Existing disturbance models for selected agents will be adopted focusing on interactions and climate sensitivity. The framework will be parameterized and evaluated in two cases studies in the Eastern Alps (Austria) and the Pacific Northwest (USA). Overall, the modeling framework aims at contributing to questions of SFEM under changing climate and disturbance regimes and facilitating a landscape perspective in forest resource management.

Keywords: individual based forest model,landscape model,disturbance interactions,climatic change,landscape ecology,sustainable forest management,ecosystem management
The BIOTELEKINESY home-care service : a communication platform for the tele-monitoring and the tele-management of the elderly to detect locomotion disabilities and prevent fall. (BIOTELEKINESY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 146876.08
EU funding (EUR): 146876.08
Participants: 1
Project status: CLOSED

The context of our ageing population and the expenses explosion linked up with healthcare request for the elderly, innovative solutions strongly related to prevention, to an improvment of the quality of life and to an upholding of an independent life as long as possible. Therefore, the core of the BIOTELEKINESY project is to provide an innovative ICT based interface with a holistic approach to detect and prevent as earlier as possible in the daily environement of the elderly person, motion disabilities and as a consequence fall risks. It will consist of a monitoring and assessing devices, to gather biomechanics data that can be indicators of locomotion impairments, related to a secure interopearbility system that connect the elderly, the healthcare providers and the family to early implement appropriate rehabilitation therapies. The method will deal with three main goals such as : firstly, the creation of a kinematic database through a clinical gait analysis to highlight and identify the biomechanics predictors of locomotion deficits ; secondly, the implementation of a real time motion recognition system for an accurate classification of elderly actions in different levels of locomotion deficits and thus the development of a treshold algorythm for the elderly activity classification ; thirdly, the development of a secure and friendly-user interface. This home-care service promise to improve healthcare management procedures with benefits both for seniors, healthcare providers and healthcare systems. In particular, it will enable to prevent fall in an effective manner in term of quality and cost by an accurate and personalized follow-up of the seniors motion capacity; a more personal and efficient interaction between them and the medical staff to implement in real time relevant rehabilitation therapy ; an improvement of the elderly compliance with the provide therapy. According to that, this project will have clear benefits for Greece and the European community.

Keywords: ageing,fall,joints,movement,biomechanics,kinematics,motion recognition,model,descriptor,monitoring,telematic,ict,healthcare,network management system,interoperability,home-care service.
Towards Understanding the mechanism of positive supercoiling by reverse gyrase from Thermotoga maritima (REV GYR MECH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-06-12
End date: 2011-06-11
Duration (months): 24.0
Total project cost (EUR): 181935.46
EU funding (EUR): 181935.46
Participants: 1
Project status: CLOSED

Reverse gyrase is the only topoisomerase known till date that can introduce positive supercoils into DNA. From the biochemical and biophysical evidence gained so far, it is known that the enzyme only relaxes negatively supercoiled DNA, and introduces positive supercoils in presence of ATP at high temperatures. The exact picture of conformational changes and inter-domain cross talk during the positive supercoiling reaction has not yet been captured biophysically. The proposed work is aimed at gaining insight into the mechanism of positive supercoiling by reverse gyrase from T.maritima and at identifying the determinants that governs this reaction. Single molecule FRET studies will be undertaken to understand how the different domains of the enzyme communicate with each other and with DNA to facilitate positive supercoiling. Real time binding studies will be carried out to understand the mode and stages of DNA binding and nucleotide binding to the enzyme. Potential DNA binding sites will be identified on the enzyme and mutants will be generated for further binding studies. This work will be the first attempt to capture the “enzyme in action” and monitor the conformational changes during positive supercoiling reaction. Achieving the specific aims of this ambitious project will significantly improve our understanding about the dynamics of the protein and the DNA during the positive supercoiling reaction and hence will unravel the underlying mechanism.

Keywords: biophysics,reverse gyrase,protein conformational dynamics,positive supercoiling,smfret,dna binding
Narrative Epileptology: A Discourse Analytical Study of Epilepsy Aimed at Clinical Applicability. (NARRATIVEPILEPTOLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 163702.68
EU funding (EUR): 163702.68
Participants: 1
Project status: CLOSED

The medical management of epilepsy has enormously progressed since the introduction of specific anti-convulsants in the 1970s and surgical treatment for worst cases, but social and personal adjustment of patients remains problematic. The ominous cultural history of this condition corroborates that prejudice and discrimination towards people with epilepsy are still widespread worldwide. Successful treatment of epilepsy therefore requires to extend beyond the achievement of seizure control to patients’ full acceptance by, and participation in, society. Our hypothesis is that if epilepsy were to be better understood within its chain of intertextuality, neurologists could improve the efficacy of their practices, by adopting a narrative approach alongside biomedical therapies of the condition. We will explore how a critical discourse analysis of epilepsy can enhance current epileptology by engendering narrative awareness and skills. Initially, we will trace the outline of the contemporary epilepsy discourse in Europe, and verify how stigma and problems of doctor-patient miscommunication are inscribed, enacted and/or resisted in it, examining literary works, recordings of interviews and therapeutic conversations. A catalogue of sociolinguistic and narrative practices will be compiled, creating a frame of reference for a tentative formulation of a programme of ‘narrative epileptology’. By means of reading, literary analysis and reflective writing, this curriculum will enhance neurologists’ interpretive skills and encourage a newly informed engagement with their clinical work. A narrative-informed approach to people with epilepsy could ultimately broaden the impact of traditional neurological therapies, providing patients not only with more personalized treatments, but also with narrative tools tailored to help them make sense of their condition (and its treatment) through guided reassessment of its significance in their particular sociocultural context.

Keywords: medical humanities,epilepsy,narrative medicine,critical discourse analysis,stigma,doctor-patient relationship,patient empowerment
Novel approaches to the study of enzymatic diffusion on single DNA molecules (SMDNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 167154.64
EU funding (EUR): 167154.64
Participants: 1
Project status: CLOSED

In cells, enzymes are able to locate and sequence specifically bind to short regions of DNA in a compacted genome of many millions of bases. This fellowship will investigate the mechanism by which they achieve this remarkable feat by examining the behavior of single enzymes diffusing on single DNA molecules. The fellowship will focus on two main objectives. The first is to exploit novel DNA-labeling technology to investigate, for the first time at the single molecule level, the effect of DNA topology on the diffusion of enzymes. Since genetic DNA is highly compacted and adopts plectonemic structures, the study of enzymatic diffusion on supercoiled DNA molecules is critical to our understanding of how enzymes interact with DNA in the cell. The second objective is to investigate the relationship between enzymatic structure and the method used by an enzyme to move on the DNA duplex. This will be done by directly visualizing structurally well-characterized enzymes as they move on a single DNA molecule. The fellow brings a background expertise of fluorescence-based techniques and molecular biology to the fellowship. The fellowship aims to train the fellow in the application of single molecule imaging to the biophysical systems that he has studied in the past. Such knowledge will significantly enhance the ability of the fellow to initiate novel research in the area of biophysical systems in the future.

Keywords: physical sciences,molecular biophysics,single molecule imaging,fluorescence
Globalisation, Trans-national Migrants and Cultural Reconstructions (GLOBALMIGRANTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-03-01
End date: 2011-10-31
Duration (months): 20.0
Total project cost (EUR): 198070.31
EU funding (EUR): 198070.31
Participants: 1
Project status: CLOSED

Since the 1990s, there has been a massive development of new forms of migration. The spaces constituted on one hand by Europe and the areas to its south, and on the other by the United States and its Latin American and Caribbean neighbours, are major scenes of this dimension of globalisation. It is not only of interest but indeed urgent to compare these new forms of migration, as has been pointed out by many specialists and decision-makers. However to date no systematic study of this type has been undertaken. Our objective is to begin to meet this need and to bring a documented contribution to the debate about migration policy in Europe and the US GLOBALMIGRANTS aims to study the experience of the migrants themselves, the changes they contribute to forms of collective action, gender relations, intercultural relations as well as their expectations as regards the political sphere. The increasingly feminine character of migration necessitates a concentration on the question of gender. GLOBALMIGRANTS comes within the continuity of a comparative study about migrants in the US and in France that the applicant is coordinating and that was selected in 2006 by the France-Berkeley Fund (FFB) GLOBALMIGRANTS pursues a) a concrete objective: to add inquiries on trans-national migrants in the UK to those already made in the US as well as in Spain and France within the FFB programme; b) a comparative and theoretical objective: to point out the common traits and differences between migrations in those different areas, but also to put categories of analysis and theoretical approaches to the test in this comparison (a synthetic and collective book about new forms of trans-national migrations will be produced).

Keywords: migration,globalisation,trans-nationalism,sociology,interdisciplinary,comparative study,europe
Modeling the surface properties of small bodies of the inner and outer Solar system (ASTROSURFACE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-09-15
End date: 2011-09-14
Duration (months): 24.0
Total project cost (EUR): 226850.39
EU funding (EUR): 226850.39
Participants: 1
Project status: CLOSED

The project is aimed to study surface properties of small bodies from the inner and outer belts of the Solar system in order to put constraints on their formation and surface evolution scenarios. We plan to develop a complex approach to derive characteristics of the topmost surface layer of atmosphereless bodies, mainly average particle size and porosity, from remote observations. The main idea is to combine observational data obtained by three different techniques: photometry, polarimetry and spectroscopy and to analyze them jointly by using semi-empirical models and available data on laboratory and numerical modeling. The approach will be tested and improved based on the comparison of surface characteristics derived from ground-based and space observations for several asteroids, including targets of Rosetta space missions 2867 Steins and 21 Lutetia. The project presents the first systematic analysis of surface characteristics of small bodies from the inner and outer parts of Solar system based on increased amount of observational data for near-Earth and main belt asteroids and transneptunian objects. The following main results are expected: (1) a new approach to constrain surface texture of small atmosphereless bodies from remote observations; (2) new data on the surface characteristics of asteroids and transneptunian objects; (3) some constraints on the models describing surface evolution processes of small bodies in the inner and outer Solar system.

Keywords: solar system,asteroids,transneptunian objects,lightscattering,surface properties,photometry,polarimetry,spectrophotometry
Identification of functional common and rare variants in the CD40 signaling pathway in Rheumatoid Arthritis (CD40RA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2010-03-31
End date: 2013-03-30
Duration (months): 36.0
Total project cost (EUR): 240709.49
EU funding (EUR): 240709.49
Participants: 1
Project status: CLOSED

Rheumatoid Arthritis is a common chronic autoimmune disease that affects approximately 1% of the adult population worldwide.Although its causes are largely unknown, it is clear that there is a considerable heritable component. In 2007, three genome-wide association studies (GWAS) as well as candidate gene approaches successfully increased the number of RA gene loci from two to five. More recently, a meta-analysis of these GWAS has been completed (Nature Genetics, in press). The most significant finding outside of the known RA risk loci was of a common polymorphism near the CD40 gene (odds ratio = 0.87, p = 5.1 x 10-9). While this represents a true disease gene, several questions remain to be answered to fully comprehend the role of CD40 mutations in RA pathogenesis. While this study provides direct evidence that CD40 is critical in RA pathogenesis, at least three crucial questions remain: 1) what is the exact common causal mutation? 2) Are there rare mutations that contribute to disease not accounted for in the genome-wide studies as they are designed to identify common mutations? 3) What is the biological relevance of both types of CD40 mutations? My proposed research will address these three critical questions by applying next generation genetic technologies (e.g., high-throughput Solexa sequencing) in large RA case-control collections available in the Plenge laboratory at Harvard Medical School (Outgoing Host Institute), together with functional immunology available in the Huizinga laboratory at Leiden University Medical Center (Return Host Institute). To achieve my goals, genetic and immunological resources will be combined to identify, validate and functionally characterise both common and rare functional mutations involved in the establishment of RA. This comprehensive approach will generate insight into a pathway relevant to disease development.

Keywords: health sciences,immunology,clinical medicine,chronic diseases,genetics,genomics,medical genetics
A new 2D-LC approach for quantitative proteomics using MeCAT labeling and multidimensional chromatography coupled to ultra-high-resolution FT-MS-MS and ICP-MS (METAG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-04
End date: 2011-05-03
Duration (months): 24.0
Total project cost (EUR): 170418.35
EU funding (EUR): 170418.35
Participants: 1
Project status: CLOSED

The quantitative analysis of protein mixtures is pivotal for the understanding of variations in the proteome of living systems. Therefore, several approaches have been devised in recent years, which generally allow only the relative quantitative analysis of peptides and proteins. We have presented proof of concept of a new MeCAT technique, which offers a quantitative determination of proteins and peptides. A macrocyclic metal chelate complex (DOTA) loaded with different lanthanides (Me(III)-ions) is the central part of the tag. The combination of DOTA with an affinity anchor for purification and a reactive group for reaction with amino acids (here: Cysteine) is a reagent that permits to quantify peptides and proteins in an absolute fashion. For the quantitative determination, the tagged peptides and proteins were analyzed using flow injection ICP-MS. With ICP-MS the metals can be detected with high precision, low detection limits and great dynamic range. The course of the labelling reaction has been studied using SDS-PAGE and MALDI-TOF-MS, ESI-MS and ICP-MS. To limit the width in isotopic spread and to increase the sensitivity, we used up to now the mono-isotopic lanthanides. The detection limit for Bovine Serum Albumin was calculated to 110 attomol; more examples have been analyzed. In this new project, 2D LC techniques interfaced to ESIMS and ICPMS will be combined with our metal tagging. Different LC types will be examined as 1st dimension and different 2D separation techniques as well. We assume that the detection limits for modified Proteins and peptides can be improved using the strategies similar to shotgun and Mudpit techniques; several model systems are available. In the next step, MeCAT will be applied for the analysis of bacterial proteomes and membrane proteins. In addition new concepts for antibody tagging will developed fro the specific detection of antigens in target proteins of medical significance.

Keywords: chemistry,analytical chemistry,instrumental analysis,quantitative proteomics,instrumental techniques,spectrochemistry