Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Islands in the West (IITW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

The project "Islands in the West" will present the first systematic study of the mythical islands of pre-Christian Europe: in a number of disciplines ranging from Scandinavian Studies to Classics, it has repeatedly been remarked that the mythological islands of Europe show striking similarities which might reflect far-reaching cultural contacts. Such remarks recur with great regularity, also in recent research contributions; this shows the widely interdisciplinary importance of the question. In spite of this, this topic has never been addressed by a dedicated study and the question is still not answered of whether these similarities in the mythical topography of Europe do indeed reflect processes of religious exchange. Nor has any attempt been made to determine what such processes could tell us about their social contexts and their importance in the life of people in early Europe. Recent methodological developments will now for the first time allow to address such questions on the basis of a methodology that is finding increasingly wide acceptance and which will make it possible to provide a methodologically well-founded and theoretically informed answer. The fellow is particularly suitable to tackle this task in the context of the IEF programme, as he has been a key contributor to the methodological developments which now permit to solve the question posed by the "Islands in the West". This topic has a particular importance for the ERA, as it addresses a prominent but so far neglected aspect of European cultural and religious history. It is of European-wide scale, reaching from Iceland to the Eastern Mediterranean, and should thus be addressed on a European level. It will have a scholarly impact both through its empirical results and through its methodological innovations. Beyond academia, the impact of its outreach activities will include the amendment of misconceptions about “Germanic” history created by the abuses of the term “Germanic” by NS-propaganda.

Keywords: cultural contact,religious contact,mythological islands,scandinavia,celtic mythology,classical mediterranean,literature,archaeology,comparative religion
Modelling of human body and protective textiles for estimation of skin sensorial comfort and life risk of fire-fighters working in extreme external conditions (MAGNUM BONUM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-08-26
Duration (months): 36.0
Total project cost (EUR): 354658.0
EU funding (EUR): 354658.0
Participants: 1
Project status: CLOSED

The objective of this IOF project is the application of finite element method (FEM) to model a digital human body (Avatar) while wearing virtual protective textiles (PTs) in order to estimate human skin sensorial comfort and life risk conditions in varied extreme external conditions, like heat, flames. The methodological context focuses on: 1) achievement of realistic human simulation (RHS) in Abaqus programme and estimation of human tissue compliance and stretch resulting from contact with PTs as well as heat stress conditions; 2) estimation of divergences between the results of laboratory wear comfort and burning tests on manikins and finite element model simulation of human torso covered by PTs. The proposed IOF project will contribute to advancement in non standard measuring techniques for investigating the interaction between human body and textiles. It will also seek to tease out the mechanisms of comfort equilibrium, skin sensorial wear comfort and prediction of comfort basing and life risk of fire-fighters, which is the novelty. The project entails a sizable training-through-research component that coexists with research plan as well as enables me to strength my international position as a scientist and to establish an independent position, which have been taken into account while designing my Personal Career Development Plan. The European host in this project is Ghent University (Belgium) and the third country host is North Carolina State University (USA). The choice of both universities is based on unique combination of top-drawer research units in tangible research domains which together sustain the ideal environment for carrying out the proposed research project.

Keywords: personal protective textiles (ppt),skin modelling,textiles modelling,digital human (avatar) from 3d body scans,heat and mass transfer
Precision Higgs Boson Self-Coupling Measurements (HIGGSSELFCOUPLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-01
End date: 2016-10-31
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

What is perhaps the most important piece of our theory of elementary particles and their interactions, aptly named the "Standard Model" (SM), has finally been discovered. The discovery of this particle, the Higgs boson, at the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), marked the culmination of years of hard work by thousands of experimental and theoretical Physicists. However, this discovery has left us with many unanswered questions, some of which the applicant's work aims to address. Specifically, the proposed project aims to improve the prospects for measuring the Higgs boson self-coupling, an important quantity in determining the role of the particle in the mechanism of the generation of masses in the SM. The proposed project will accomplish this by developing advanced Monte Carlo event generator tools for the production of pairs of Higgs bosons at the LHC, as well as improving the search strategies for channels via modern jet sub-structure and statistical techniques. Additionally, the effects of potential New Physics that could appear in the process will be examined and quantified in detail. The applicant's knowledge and experience as an author of the Herwig++ general-purpose Monte Carlo event generator, an important tool used by experimentalists, are crucial towards achieving his objectives. The Host Organization, CERN, provides the ideal location for the application to strengthen his ties with the experimental physicists working there, as well as maintain his excellent global collaborative connections.

Keywords: particle physics,cern,hadron colliders,lhc,higgs boson,new physics,monte carlo event generators,qcd.
Risk assessment of inorganic arsenic in EU rice-based infant products and strategies to reduce exposure (RICENIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-28
End date: 2016-04-27
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Inorganic arsenic (i-As) has been identified as a non-threshold carcinogen. Children are particularly susceptible to As exposure and early-life exposure may adversely affect long-term health, yet there are no EU standards for i-As or total (t-As), given that i-As in water is tightly regulated yet food sources dominate EU exposure. The levels of tolerable dietary exposure to i-As have been reviewed and the WHO Tolerable Weekly Intake has been withdrawn as data has shown that i-As causes cancer and other health problems at lower exposures. The main exposure route to i-As in the EU is dietary, and rice is the main source. Rice accumulates significantly higher levels of As than other crops. Infant consumers of rice-based products are one of the population groups in the EU with higher exposure levels. However, exposure calculations have been based on occurrence figures of t-As from limited and non-representative numbers of samples. More As speciation data for different rice-based infant products are required to support dietary exposure assessment and define risk assessment of i-As. The main objectives of the RICENIC project are i) provide an accurate risk assessment of i-As exposure of EU infants and ii) set up feasible recommendations to reduce i-As burden in rice-based infant products based on agricultural and industrial practices. The expected results are a) the generation of a database of t-As, i-As and As bioaccessibility/bioavailabiliy in cereal-based infant food marketed in the EU, b) the assessment and risk characterization of i-As in EU infants, c) determination of the effects of the agricultural practices on the As concentration and speciation in rice grain, d) determination of the effects of manufacturing processes on the As concentration and speciation in rice-based infant products and e) enhance the framework for understanding i-As in the human diet with respect to informing the setting of i-As standards in food.

Keywords: arsenic speciation,risk assessment,babies' urine,rice,rice-based products,bioaccessibility,bioavailability,agricultural practices,industrial processes,modeling and eu standards.
Magnetically Enhanced Controlled Axonal Regeneration (MECAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-07
End date: 2016-07-06
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Although the exact mechanisms involved in the growth of axons is still incompletely understood, it is clear that force is a crucial factor for both axonal guidance and lengthening. Indeed, there is a growing body of evidence indicating the importance of physical stimuli for neuronal growth and development. Results of published experimental studies indicate that forces, when carefully controlled, act as powerful stimulators of axonal lengthening. This proposal seeks to develop, test and evaluate a practical implementation of this concept. Specifically, it aims to establish a novel approach for the application of a controlled tensile force to neurones and axons in order to accelerate nerve regeneration after peripheral nerve injury. The methodology based on the use of magnetic nanoparticles (MNPs) and magnetic field, meets the pre-requisites for eventual translation to clinical practice as both components - static magnetic fields and MNPs - are in established use, the first in magnetic resonance imaging (MRI) and the latter as MRI contrast agents and Fe therapy. The research group which I lead has demonstrated in a neuron-like cell line (PC12) that MNPs can direct the neurite outgrowth along the direction imposed by an external magnetic field. This proposal will translate this concept into a model of regeneration of peripheral nerve.

Keywords: conduit,magnetic field,trophic nerve factor,nanoparticle,organotypic co-cultures,mice
Collective Syntheses and Biological Evaluation of Akuammiline Indole Alkaloids (STRICTSYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 207928.8
EU funding (EUR): 207928.8
Participants: 1
Project status: CLOSED

Natural product chemistry plays a pivotal role in drug discovery. A recent authoritative survey indicated that 61% of marketed drugs in the period of 1981-2002 could be traced to or were inspired by natural products. Since the composition and content of natural products vary from multi-factors, total synthesis has been considered as one of the most important components in the exploration of natural products. The proposal aims at addressing the collective syntheses of a series of bioactive indole alkaloids (strictamine, aspidophylline A and alsmaphorazine C) from a common intermediate. Moreover, bioactivities of these natural products as well as advanced intermediates and analogues will be evaluated by both high throughput screening and focused bioassays to explore their full potential. The target molecules have been reported to possess potent bioactivities, but their very low natural abundance hampered their detailed biological studies. Although considerable synthetic efforts have been made, no total synthesis of strictamine and alsmaphorazine C has been achieved due to their complex molecular architectures. The proposal presents novel and concise synthetic strategies featuring an earlier-stage quaternary carbon formation and a late-stage indole synthesis blueprint. Furthermore, the synthesis could be performed in both protective group-free and asymmetric versions, which perfectly matches the growing demand for economy of synthesis and drug discovery. Since the project is multidisciplinary merging organic chemistry, medicinal chemistry and biology, it will certainly represent a high-quality contribution to the research fields in Europe and may constitute the basis for the discovery of a new generation of potent lead compounds for drug discovery. At the same time, it offers a fantastic opportunity for the candidate to transfer her knowledge and skill to the host lab and Europe, which is beneficial to the European citizens as well as the pharmaceutical industry.

Keywords: collective syntheses,organic chemistry,natural product,indole alkaloids,biological evaluation,strictamine,aspidophylline a,alsmaphorazine c
SUPPRESSION OF RNA DEGRADATION BY PLANT PARARETROVIRUS: HIJACKING OF DECAPPING COMPLEXES (DEGRAVIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

During pathogenesis, viruses hijack the cellular machinery to access molecules and sub-cellular structures needed for infection. Viruses counteract plant defences by producing suppressor proteins. We have evidence that multifunctional viral protein—translation transactivator/ viroplasmin from Cauliflower mosaic virus, CaMV—could be used as a suppressor of cellular RNA turnover: the cellular accumulation of TAV inhibits cellular mRNA decay and suggests its complex formation with the decapping machinery within P-bodies. We shall investigate whether TAV of CaMV and related pararetroviruses serves as a suppressor of cellular and viral RNA degradation, and whether TAV is operated within either the deadenylation complex, which primes mRNA degradation, and/or the decapping complex, where TAV integrates. We shall test whether transient or stable over-expression of the CaMV TAV as a wild type or a mutant form is able to suppress degradation of cellular or viral RNAs. We shall determine the component of the degradation machinery that ensures TAV entry into the decapping complex/ P-bodies. Thus, we are interesting in studying the TAV interaction network within the decapping/ deadenylation complexes. These studies should reveal whether viral protein-based suppression of RNA degradation is a universal mechanism employed by plant pararetroviruses and, perhaps, also animal retroviruses. Additionally we shall identify RNA-based targets within cellular and viral mRNAs, and study whether synergistic suppression of RNA degradation by viral suppressor might contribute to CaMV virulence. This will help to design new strategies to counteract mRNA degradation in general using plant pararetroviral vector.

Keywords: plant pararetrovirus,cauliflower mosaic virus,translation transactivator/ viroplasmin tav,mrna decay,decapping complex,deadenylation complex,vcr/ vcs,dcp1,dcp2,translation initiation,eif3
Internal and inertial wave focusing and instability in closed fluid domains (WAVE ATTRACTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-01
End date: 2016-06-02
Duration (months): 24.0
Total project cost (EUR): 269743.8
EU funding (EUR): 269743.8
Participants: 1
Project status: CLOSED

Energy transfer from large to small scale is a critical issue in the dynamics of ocean and atmosphere, and also an important fundamental question. Owing to density-stratification and rotation, ocean and atmosphere support internal and inertial waves which are known to propagate in form of oblique beams. Dispersion properties of these waves lead to strong variation of beam width upon reflection at a sloping boundary. In confined fluid domains, successive reflections may lead to formation of a closed trajectory, an internal wave attractor. Thus, the energy input at a global scale can be strongly concentrated on a closed loop of finite width, implying nonlinear instabilities very likely to occur. They arise indeed in form of parametric subharmonic instability which generates secondary waves having smaller scale than the width of the wave beams of the attractor. This two-step mechanism has been revealed experimentally by the applicant of this project during a short visit to the host organization. It was observed also that at large amplitude of input perturbation a patchwork structure of internal wave field is formed which hardly bears a resemblance to a classic pattern of a wave attractor. Observations of patchwork structures in ocean were recently reported in the literature. The scientific goal is to investigate this mechanism with an emphasis on issues important for interpretation of oceanographic data: What is the influence of the scale effects? How does the threshold amplitude needed to destabilize an attractor depend on the Reynolds number? How does the Reynolds number affect the spatial scale of secondary waves? Does the type of instability change (locally?) with amplitude of oscillations? How is formed the patchwork structure of the wave field? What are the energy contents of different components of the wave field? Are the key mechanisms similar in stratified and rotating fluids? We are aiming to answer these questions by launching a broad experimental campaign.

Keywords: geophysical hydrodynamics,stratification,internal waves,hydrodynamic stability,attractors
Citizenship in a Digital Age (CIDA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-01
End date: 2018-01-01
Duration (months): 36.0
Total project cost (EUR): 270312.9
EU funding (EUR): 270312.9
Participants: 1
Project status: CLOSED

Does mobile digital technology transform citizenship relations? Does it change the way we think about participation, equality and rights? Despite the rise of terms such as 'digital citizenship' and 'netizens' and a widespread belief that digital technology will revolutionize democracy, many scholars argue that the emancipatory potential of digital technology is overstated. At the same time prominent scholars such as Slavoj Zizek and Judith Butler claim that there is a fundamental crisis of representative democracy. The proposed research builds on the anthropology of citizenship which takes the experience of citizens as the starting point for analysis, to offer an in-depth examination of how, and to what extent, digital technology is being used within three citizen projects in the San Francisco Bay Area to answer: How do people use mobile, networked digital technology to create, reproduce or challenge forms of 'differentiated citizenship' (Holston 2008)? The Bay Area is chosen for this research because it is a leader in the field of digital technology development and it has a long history of strong civic engagement. The proposed research develops an original methodology, dubbed 'digital context construction', that brings tried and tested ethnographic methods, ideal for gathering rich and detailed data about social behaviour in context, together with the latest developments in digital data analysis. This methodology expands on existing anthropological techniques that include an analysis of how people integrate digital technology into their daily lives as they self-construct a 'context' that is both locally embedded (e.g. use of internet to find a local service) and global in reach (e.g. posting on Facebook about events far away). This study will produce one of the first detailed accounts of how digital technology shapes the way people envision time, space, distance, speed, and the future, and how disjunctures of time, in turn, transform practices of citizenship.

Keywords: citizenship,digitization,political anthropology,democracy,participation,rights,equality