Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Anti-Cancer Light-Controllable Antibody-Peptide Conjugates (ALISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Ukraine,Latvia,Netherlands,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 745200.0
EU funding (EUR): 745200.0
Participants: 7
Project status: SIGNED

Project ALISE (Antibody Light-Induced Selectivity Enhancement) will integrate the expertise, resources and knowledge of participating Institutions focusing on design, synthesis and preclinical study of conjugates of monoclonal antibodies with peptides whose anti-cancer activity can be enhanced in tumours by irradiation with light (LC-APCs). The possibility to boost the anti-cancer activity only in tumours, multiplied by targeting cancer cells by antibodies will be a basis for innovative and safer therapeutic strategies. Four of seven participating Institutions successfully collaborated in the field of light-controllable anticancer peptides, but this Project will widen the scope of collaboration, both in terms of the research field and collaborating Institutions. The participating Institutions are complementary in their expertise and know-how: the University of Cambridge will contribute with its know-how in design and preparation of antibodies. Light controllable peptides will be designed at Latvian Institute of Organic Synthesis and Karlsruhe Institute of Technology, synthesized, then loaded onto the antibodies in Cambridge. Company Enamine will perform initial screening of the conjugates in vitro and assess their safety. National Cancer Institute of Ukraine will contribute with its expertise in immunology, Cancer Center Amsterdam – with its expertise and knowledge in preclinical and clinical oncology. Lumobiotics GmbH will complement the consortium with its expertise in drug development. Integration of this potential will be achieved through research staff exchange and other activities organized in five work packages: 1) design and synthesis of novel light-controllable peptides as anti-cancer antibody payloads; 2) preparation and characterization of peptide conjugates with a model antibody; 3) biological screening of model LC-APCs; 4) preclinical evaluation of the LC-APCs aiming at treatment of human PDAC; 5) management, training, communication, dissemination.

Keywords: antibody drug conjugates,molecular photoswitches,photocontrolled drug candidates
Remote technical assistance for field service operators (RemoTech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In current competitive manufacturing market, continuous operation of machineries becoming the vital point and is considered to be the key performance indicator of productivity. Machine downtime costs time and money for enterprises. EU business community losses almost 1 million hours per year due to machine downtime. In general, it takes ca. 54 hours per year for a company to repair machines and it losses ca. €0.35 million per year for on premise machine-repair. Thus it is very important to have an integrated solution to reduce this expensive inconvenience as quickly as possible. We have developed an innovative software based solution for providing remote technical assistance to field service operators by support department experts. Currently, RemoteEye is the only telepresence solution in the market available adopted for wearable technologies e.g. smart watch and smart glass. Additionally, our easy, fast and cost effective system can also be used by smart phones, tablets (iOS and Android) and desktop computers. Our aim is to become the pioneer in remote telepresence solution with main attention on wearable and/or augmented reality where we can outperform our competitors. Our system solves the issue and saves time and money by reducing technicians’ travel time and expenses. The cost for the client is only a small fraction compared to the money saved through repairing their machinery in a fast and efficient process. With our software, we initially estimate technical assistance savings of 62%. This project will study the detailed nature and extent of the field service market, the interrelation between various market factors, new technology and technological trends that may influence the market. Based on the results the solution will be further enhanced, detailed and scaled up.

Keywords: wearable technology remote assistance,machine downtime,telepresence solution,augmented reality
Electrophilicity-Lifting Directed by Organochalcogen Redox-Auxiliaries and Diversiform Organocatalysis (ELDORADO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1499953.61
EU funding (EUR): 1499953.61
Participants: 2
Project status: SIGNED

The implementation of viable practices for the ecologically cognizant production and consumption of energy and renewable resources rank among the most pressing societal challenges of the 21st century. Against this background, the design and development of innovative concepts for the sustainable use of energy and energy-rich compounds from regenerative sources becomes a matter of profound technological and scientific pertinence. A promising approach that has been put forward in the context of chemical synthesis is the application of visible light as an inexpensive source of energy and air as an abundant and gratuitous oxidant for the derivatization of certain hydrocarbons. Despite the enormous economic and ecological benefits associated with the use of light and air as integral components of redox reactions, the realization of such processes is strikingly limited to very isolated applications. Consequently, this methodological deficit represents a momentous opportunity for modern chemical sciences to lastingly transform the routine lines of action for the oxidative manipulation of organic molecules. A key issue that needs to be taken into consideration for the design of efficient light-driven aerobic oxidation protocols is the identification of proper catalyst systems that allow for the site- and chemoselective activation of individual bonds within polyatomic frameworks. In this regard, the prime objective of the proposed research program is the rational design of non-metallic and in part cooperative catalysis regimes as enabling technologies for the electrophilic activation of non-aromatic carbon–carbon multiple- and carbon-chalcogen single bonds to facilitate a wide and diverse array of heretofore unprecedented oxidative coupling-, addition-, and rearrangement reactions. To demonstrate its utility in a superordinate context, this methodological concept will be applied in highly modular enantioselective syntheses of biologically relevant polyketide natural products.

Keywords: organocatalysis,method development,oxidation reactions,alkenes,alkynes,selenium,sulfur,total synthesis
Alternative splicing and SR proteins in ABA-mediated plant stress responses (AS-ABA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and a flexible means of regulating gene expression in higher eukaryotes. While its functional relevance in plants remains largely unknown, mounting evidence suggests a central role for AS in the response to abiotic stress, in particular by targeting the ABA hormonal pathway. Using gene expression analyses, subcellular localization studies and reverse genetics approaches, this project will investigate the functional significance of six ABA-regulated Arabidopsis SR genes in stress responses mediated by the ABA phytohormone. To gain mechanistic insight into the mode of action of the SR proteins implicated in the ABA pathway, the physiological transcripts targeted by these splicing factors to achieve plant stress tolerance will be identified using a combination of genome-wide and biochemical approaches. In brief, next-generation sequencing technologies will be applied to whole transcriptome analysis (RNA-seq) of plants with altered levels of an SR protein and to RNA immunoprecipitation (RIP-seq) in plants expressing a tagged version of the SR protein. In discovering new plant genes that determine the ability to cope with unfavorable environmental conditions and by revealing the molecular mechanisms underlying their mode of action, this work will pave the way for the development of new efficient strategies to improve crop productivity in specific world regions.

Keywords: abiotic stress responses,abscisic acid aba,alternative splicing,arabidopsis thaliana,sr proteins
SeaDataCloud - Further developing the pan-European infrastructure for marine and ocean data management (SeaDataCloud)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Estonia,Italy,Germany,Iceland,Ukraine,Germany,Germany,Spain,Ireland,Italy,Italy,Israel,Germany,Italy,Malta,Cyprus,Belgium,Finland,Norway,Türkiye,Belgium,Greece,Sweden,Belgium,Bulgaria,Greece,Croatia,Poland,Poland,Romania,Slovenia,Russian Federation,Georgia,Latvia,France,France,France,Netherlands,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,United Kingdom,Portugal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2016-11-01
End date: 2021-04-30
Duration (months): 54.0
Total project cost (EUR): 9999737.5
EU funding (EUR): 9999737.5
Participants: 61
Project status: CLOSED

The SeaDataNet pan-European infrastructure has been developed by NODCs and major research institutes from 34 countries. Over 100 marine data centres are connected and provide discovery and access to data resources for all European researchers. Moreover, SeaDataNet is a key infrastructure driving several portals of the European Marine Observation and Data network (EMODnet), initiated by EU DG-MARE for Marine Knowledge, MSFD, and Blue Growth. SeaDataNet complements the Copernicus Marine Environmental Monitoring Service (CMEMS), coordinated by EU DG-GROW. However, more effective and convenient access is needed to better support European researchers. The standards, tools and services developed must be reviewed and upgraded to keep pace with demand, such as developments of new sensors, and international and IT standards. Also EMODnet and Copernicus pose extra challenges to boost performance and foster INSPIRE compliance. More data from more data providers must be made available, from European and international research projects and observing programmes. SeaDataCloud aims at considerably advancing SeaDataNet services and increasing their usage, adopting cloud and HPC technology for better performance. More users will be engaged and for longer sessions by including advanced services in a Virtual Research Environment. Researchers will be empowered with a collection of services and tools, tailored to their specific needs, supporting marine research and enabling generation of added-value products. Data concern the wide range of in situ observations and remote sensing data. To have access to the latest cloud technology and facilities, SeaDataNet will cooperate with EUDAT, a network of computing infrastructures that develop and operate a common framework for managing scientific data across Europe. SeaDataCloud will improve services to users and data providers, optimise connecting data centres and streams, and interoperate with other European and international networks.

Keywords: data management,marine and ocean data,standards,virtual research environment,cloud,high performance computing,networking,oceanography,marine chemistry,biology,geology,geophysics
Residential Building Energy Renovations with On-Bill Financing (Ren-on-Bill)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Italy,Germany,Spain,Italy,Italy,Lithuania,Belgium
Call: Innovative financing for energy efficiency investments (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 1661872.5
EU funding (EUR): 1661872.5
Participants: 12
Project status: CLOSED

Ren-on-Bill’s overall objective is to scale up investments towards deep energy renovations (ER) of residential buildings by promoting the development and implementation of On-Bill Financing schemes, based on the cooperation between energy utilities and financial institutions. On-Bill Financing (OBF) is a method of financing ER investments that draws on utility bills as repayment vehicle. OBF has been in use for more than 30 years, and it is especially widespread in the USA and Canada, where it significantly drives the building renovation market, with over 1 billion $ investments reached by 2013. Compared to traditional loans, default rates have been found to be lower, thus making OBF a lower risk instrument for investors. In Europe, although a few attempts have been made, OBF has not yet had a significant impact on the residential energy efficiency building renovation market. In detail, the project will: - Analyse and define the residential building ER and OBF market context to enable replication of suitable OBF schemes across Europe; - Engage key stakeholders (in particular energy utilities, financial institutions, representatives of the final user and ER market side) through national stakeholder platforms; - Develop tools to structure the residential sector’s ER financing demand allowing allows utilities and financial institutions to assess ER investments based on a transparent methodology and to bundle investments accordingly; - Develop suitable utility business models for the deployment of deep energy renovation OBF schemes for residential buildings in Europe; - Implement selected OBF business models at the 3 Ren-on-Bill partner utilities through a collaboration for strategic development of pilot on-bill financing schemes; - Exploit the insights gained over the project horizon to support European-wide dissemination of knowledge on OBF schemes towards utilities, financial institutions and policy-makers.

Keywords: on bill financing,energy renovation,residential buildings,energy efficiency,utilities sector
Enabling End-to-End HDR Ecosystem (HDR4EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Belgium,United Kingdom,United Kingdom
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-07-01
End date: 2020-06-30
Duration (months): 36.0
Total project cost (EUR): 2935000.0
EU funding (EUR): 2234125.0
Participants: 6
Project status: CLOSED

HDR technology can provide a never before seen increase in contrast, colour and luminance, producing images of unsurpassed realism and immersive potential, and is lauded in the creative sector as a truly transformative consumer experience, representing “the most exciting format to come along since color TV”. All the possibilities that the HDR format could offer, in terms of market growth for companies and improved user experience for the viewer, depend upon the existence of a fully functional HDR ecosystem. But we are currently a long way from such an ecosystem, as stated in very recent reports from several international organizations and standardization bodies, due to open challenges happening at all stages of the production chain, from capture to display. The main goal of HDR4EU is to position EU companies in the creative sector as world leaders in the emerging HDR format by producing a set of professional tools, techniques and guidelines allowing for an HDR ecosystem to emerge, yielding a notably superior viewer experience in terms of image quality and content personalization. HDR4EU will: - Showcase close-to-market and pilot versions of new technologies addressed to HDR content, catering for different communication and delivery platforms, and highlighting the feasibility and possibilities of an end-to-end HDR pipeline. - Allow a user to have the best possible HDR experience on the outlet of their choice (cinema, TV, mobile device, AR/VR headset) by producing tools to meet new user expectations in hyper-personalized content consumption, using data and metadata generated during production, coming from the display device and its viewing environment, and taking into account individual characteristics and preferences. - Provide content creators with tools to fully exploit the expressive possibilities of their media with HDR technology, making HDR media and HDR content converge onto an overwhelmingly better, at a whole different level, viewer experience.

Keywords: hdr ecosystem,hdr pipeline,cinema,broadcast,media production,media post production,display technology,projection systems,graphics,personalization,visual perception,viewing experience
EUropean ROBotic framework for bipedal locomotion bENCHmarking (EUROBENCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Iceland,Spain,Spain,Italy,Italy,Spain,Netherlands
Call: System abilities, SME & benchmarking actions, safety certification (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 8190691.25
EU funding (EUR): 8190691.25
Participants: 13
Project status: CLOSED

The EUROBENCH project aims at creating the first benchmarking framework for robotic systems in Europe. The framework will allow companies and researchers to test the performance of robots at any stage of development. The project will primarily focus on bipedal machines, i.e. exoskeletons, prosthetics and humanoids, but will be designed to be easily extended to other robotic domains. The EUROBENCH framework will be composed of: - A methodological component, which will include methods and metrics to calculate the System Ability Levels of a robotic system. These methods will be integrated in a professional software tool to permit its wide use across domains and laboratory conditions. The main goal of this unified software is to facilitate the use of benchmarking methodology at all levels from research to pre-commercial prototyping. - An experimental component, which will concentrate the state-of-the-art test benches in two facilities, one for wearable robots (including exoskeletons and prostheses), and one for humanoid robots. These facilities will allow companies and researchers to perform standardized tests on advanced robotic prototypes in a unique location, saving resources and time, and preparing for certification processes. During the project, the Consortium will provide Financial Support to Third Parties interested in: - Designing and developing specific test benches or benchmarking methods. These solutions will be integrated into the framework, and made available to the industrial and academic community. - Using the framework, at zero-costs, to test the performance of different kinds of robots. This will allow to validate the EUROBENCH outputs and prepare for the exploitation of results. The successful achievement of these goals will put Europe in the lead on providing the groundwork for the evaluation of robotic systems, facilitating the process of bringing innovative robotic technologies forward to market.

Keywords: benchmarking,wearable robots,humanoids,exoskeletons,prostheses,system abilities,testing facilities,standardization,assessment,test benches
crIpeC nAnomedicines’ micRodistribution in tUmour tiSsue (ICARUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2020-10-01
End date: 2021-11-30
Duration (months): 14.0
Total project cost (EUR): 184107.14
EU funding (EUR): 128875.0
Participants: 1
Project status: CLOSED

Cristal Therapeutics (CT) is an innovative SME based in the Netherlands dedicated to the creation of the next generation of targeted nanomedicines (NM). CT has developed CriPec, a nanoparticle technology that can entrap a wide range of drugs, transforming them into custom-made NM. CriPec-based products have demonstrated excellent pharmacokinetics and tumour accumulation as well as highly improved safety, both in laboratory and patient settings. However, the full therapeutic potential of CriPec has not been obtained due to a lack of understanding of its tumour microenvironment (TME) microdistribution and behaviour, hindered by the lack of highly specific (bio)analytical expertise within Cristal Therapeutics. ICARUS will enable CT to solidify its position as an innovative SME and provide them a competitive edge through hiring an Innovation Associate (IA). The envisioned IA will develop and implement state-of-art (bio)analytical methodologies (including advanced MALDI-techniques) that have not been exploited in the field of NM until now, and that will provide CT with essential insights that will guide the composition optimisation of all CriPec-based products. Furthermore, the ICARUS project is heavily focused around the training of the IA, thereby greatly improving his/her career development. A training programme tailored to his/her specific needs and personal career development plan will be developed, allowing the IA to: • Gain novel skills and experience on every aspect of the development of nanoparticles, encompassing the required multidisciplinary expertise from several fields; • Gain innovation and business related skills in a multidisciplinary setting.

Keywords: bio analytical chemistry,nanomedicine,maldi,mass spectrometry