Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VISIOCYT SCREENING: A DISRUPTIVE ARTIFICIAL INTELLIGENCE SOLUTION FOR BLADDER CANCER SCREENING (VISIOCYT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bladder cancer is the 5th most common cancer in Europe, with almost 200,000 new cases and 65,000 deaths estimated in 2018. People at high risk for developing this disease include smokers, former smokers, people living in polluted areas, and workers exposed to certain chemicals. The risk of dying from bladder cancer depends on the time of diagnosis and the tumour’s grade: the 5-year survival rate is >95% in early stage cancer, but it drops to <5% in late stage tumours. Besides increased survival, the identification of bladder cancer at its early stages is also associated with easier, less invasive, and cheaper treatment. Given the importance of early detection and the high incidence of bladder cancer, screening programs for this disease are needed. However, there is no screening tool currently available for bladder cancer. As a solution, VitaDX is developing VisioCyt Screening: a software that combines artificial intelligence algorithms with standard cytology analysis to predict with high accuracy the presence of bladder cancer in patients, even before symptoms appear. Being a software that analyses images obtained through regular clinical procedures, VisioCyt Screening can be readily implemented in centralized labs, resulting in a fast, easy-to-use, reproducible, automated, and high-throughput solution at a low price. VisioCyt Screening can be classified as an in-vitro diagnostic (IVD) medical device. The global IVD market was estimated at €58 billion in 2018, and is expected to reach €75.2 billion by 2023, with a CAGR rate of 5.2%. In this market, centralized laboratories, which perform large numbers of analyses in few locations and are equipped with the automated systems required by the VisioCyt solution, represent the most relevant target users and customers for VitaDX. VitaDX is a French SME that combines a strong scientific and clinical background with software and image processing skills and business expertise to develop new diagnostic solutions for cancer.

Keywords: cancer screening,image processing,bladder cancer,artificial intelligence,machine learning,brightfield microscopy,atypical cell types
Preclinical development of squalenic acid and gemcitabine squalene nanomedicine (SQUALAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France,France
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-03-01
End date: 2016-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene. This approach is unique and has never been used before. The so called "squalenoylation" technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug release triggered by the spacer between the drug and the squalene moiety. Remarkably, it was shown that these nanomedicines were more efficient and less toxic than the parent drugs. The gemcitabine-squalene (Gem-SQ) nanomedicine, our first candidate for further pharmaceutical developments, was shown not only to display an impressive anticancer activity in experimental tumors but also to overcome drug resistance, thus addressing a major challenge in tumor therapy. These pre-clinical data deserve further development towards translation into the clinic for the treatment of the pancreatic cancer, a devastating disease. However, the squalenic acid (SQCO2H), the chemical template essential for the synthesis of the Gem-SQ bioconjugate, is currently obtained through the Van Tamelen reaction which cannot be employed for the preparation of a clinical sample of Gem-SQ, because of the use of CrO3 (a toxic compound) and the poor yield of the reaction. Therefore, the synthesis of SQCO2H represents a lock for further clinical development of our Gem-SQ nanomedicine. The goals of the present proposal are : (i) to perform the total synthesis of SQCO2H through a new « green » chemistry way (which represents in itself a real innovation) allowing (ii) further regulatory acceptable preparation of Gem-SQ nanoparticles. Incidentally, the total synthesis of SQCO2H will avoid environmental concern due to excessive shark hunting and represents by itself some economical value as excipient for the cosmetics.

Keywords: squalenic acid,gemcitabine squalene,nanoparticles,anticancer nanomedicine
The long-term effects of unemployment on older workers: Studying life-course influences in social context (NoWork)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-01
End date: 2017-12-31
Duration (months): 20.0
Total project cost (EUR): 149438.0
EU funding (EUR): 149438.0
Participants: 1
Project status: CLOSED

Europe’s population is currently the oldest in the world, and it is still ageing. This demographic shift is changing societies in an unprecedented way. Researchers and policy-makers fear that we will now only have sustainable pension schemes and a sufficiently numerous, well-qualified workforce if people work until old age. Consequently, many current policies strive to increase workforce participation and delay retirement. But can such policies for older workers be effective? Life-course scholars argue that experiences have time-delayed effects. What people experience during youth and mid-age influences whether they work in old age. Thus, policies for older workers may intervene at too late an age to make a difference. This study investigates time-delayed effects on older workers. It focuses on the effects of unemployment spells, which are said to scar work biographies and permanently hamper careers. This study uses the life-course perspective and thereby joins the newly emerging group of empirical studies that consider entire work biographies to explain workforce participation in old age. Its unique contribution is that it considers the role of social context in the form of families and economic crisis. Family members often coordinate their workforce participation and retirement timing. Economic crises increase unemployment rates, which affects the meaning and experience of being unemployed. This study compares the “most different cases” of Finland, Germany, Italy, Poland and the United Kingdom. Data stem from life-history interviews in the “Survey of Health, Ageing and Retirement in Europe”, the “English Longitudinal Study of Ageing”, and a self-administered Finnish survey. The approach combines sequence, cluster, regression and correlation analyses. Findings refine theories on old age, life-courses, labour markets, welfare states, and economic crises. Policymakers can use the insight gained to refine labour market policies.

Keywords: old age,life course,paid work,family,economic crisis
Feasibility study of a new tool for managing, processing, sharing and transferring huge amounts of scientific data (DataNimbus) (DataNimbus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We are currently living in the Big Data era in which different technologies produce thousands of terabytes of data every minute. Real value of this data remains on the information that can be extracted and understood from it, not only on its creation. As data is generated so fast, we need to be able to transfer, process and analyse it, so we can understand it as fast as it is generated. This is a key concept for Bioinformatics, which aims to make personalized medicine a real thing. In this field, Big Data from omics Sciences (Genomics, Transcriptomics, Proteomics and Metabolomics) is usually processed far from the place of generation and files are transferred using FTP or moved using hard disks. We will develop DataNimbus, a commercial solution to transfer, store, share and analyse this bioinformatic data from a single product. Existing solutions are not able to cover all of these needs. DataNimbus aims to bring closer usually expensive and unaffordable data movement and processing technologies to European SME and research facilities. This solution will be cloud based, offered on a pay-per-use basis. Cloud computing usage implies some economic and environmental advantages, and also provides some other strong benefits like resiliency and redundancy, go faster on the projects deployment, scale as needed and lower maintenance costs. Finally, cloud approach will allow us to build our infrastructure with its real needs. The proposed work, objectives, will be summarized on a detailed business plan and a feasibility study. To reach it, a market study will be done, allowing us to locate main potential customers, make agreements or contacts with partners and hardware providers and validate our commercialization strategy and market segmentation. It will be also supported with the analysis of different financial strategies to support the product development.

Keywords: big data,cloud,data management,bioinformatics,genomics,data knowledge,compression algorithms
Audio-Visual System for the Blind Allowing Visually Impaired to See Through Hearing (EyeSynth)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 1478950.0
EU funding (EUR): 1035265.0
Participants: 1
Project status: CLOSED

According to the World Health Organization, there are approximately 285 M visually impaired around the world, of which 39 M are blind and 246 M have reduced vision. These figures are expected to increase drastically on coming years mainly due to the main risk factors sight damage 1) ageing of population and 2) increased prevalence of type 2 diabetes, which is mainly driven by excessive consumption of processed foods containing added sugars. Currently, blindness has no cure, and unfortunately, will not have it on the near future. As a result, the unique action that visually impaired can take is to use assistive devices to cope with their condition. The most widely used approach is the so-called cane together with guide dogs. This devices are solely intended to avoid obstacles and navigate to locations that the dog is been trained for. However, these approaches have huge limitations singe are solely intended to avoid obstacles, not allowing blind to understand their environment. Eyesynth has developed for the first time an audio-visual system consisting of a glasses embedded with a pair of cameras that are able to accurately reconstruct a 3D scene and codify it into abstract and easy to understand audio for the blind. We can see it as an advanced sonar that stimulate certain brain zones allowing blind to associate spatial information with abstract sounds, being possible to interpret the environment with an unprecedented level of detail. We will sell our product first through a B2B approach, partnering with large organizations for blind, associations, ophthalmologist and optical stores. Once initial traction and product trustiness is achieved, we will move to B2C through online distribution By these means we will enter the global market for assistive technologies for visually impaired, which will grow at < CAGR of 7% until 2020, reaching a value of almost € 2,2Billion. We expect to achieve a turnover of €27,7M in 2013, generating 36 new employments.

Keywords: assisted living,assistive technology for blind,assistive technology for visually impaired,embedded systems,wearables,audio digital signal processing,audio visual systems,firmware,software
Simple, immediate and economical access to company credit rating and financial information. (S-PEEK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

"S-PEEK delivers immediate, professional and transparent certified credit reports on every company in Europe allowing users to understand and assess the economic and financial reliability of potential business partners, such as suppliers, clients, distributors. The reports come in 3 formats varying in detail and price. The reports are easy to use and apply modeFinance’s Multi Objective Rating Evaluation (MORE) methodology that simplifies the financial data and credit rating into a colour coded scheme that makes decision making via company reports possible for every user. By analysing this information and making it easily available in a simplified format, modeFinance intends to level the playing field for SMEs to make use of financial corporate information, currently used only by large enterprises. Thanks to S-PEEK, SMEs can make decisions based on up-to-date financial data, thereby potentially avoiding encountering problems associated with companies with ill finances, e.g. losing money. S-PEEK also saves vast time for the users, by making available all company reports via the web or smart device application. Previously companies would have to request expensive complex reports from specialised firms or directly from the company. S-PEEK is available in a preliminary release in Italy. The innovation project intends to improve the mobile application robustness and to widen the database to include the company data in economies of United Kingdom, Germany, France and Spain, followed by the rest of Europe. Once commercialised S-PEEK intends to increase the internationalisation of European SMEs by improving the transparency and readiness of relevant company data through the Union. "

Keywords: fintech,innovative software,data use
Repurposing small RNA from ciliates for genome editing: single-molecule study (MIGHTY_RNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 1792850.0
EU funding (EUR): 1792850.0
Participants: 1
Project status: SIGNED

Genome editing is an essential tool for life sciences. Recent ground-breaking discovery in microbiology drew our attention to the genome editing ability of bacteria (CRISPR). Since its discovery, CRISPR has revolutionized the way of editing a genome. Despite its wide use, CRISPR-genome editing has limitations, especially in the use for medical applications. Numerous studies have shown that it suffers from the off-target effect. Its use is also restricted by its particular sequence requirement and its poor accessibility to a structured genome. Furthermore, recent studies suggested that it might act as a virulence factor within human cells. These limitations demand new genome editing tools. This proposal sets out to understand the molecular mechanism of Tetrahymena DNA elimination. This naturally occuring genome editing is mediated by a eukaryotic RNA system (Twi1). This system uses an entirely different mechanism from CRISPR and has potential to perform more effectively. I will first investigate how small RNA-loaded Twi1 (“target searcher”) recognizes its target and whether its performance exceeds other target searchers including CRISPR/Cas9. I will use single-molecule fluorescence for high resolution observations and develop a high-throughput single-molecule method for transcriptome-wide understanding. Second, I aim to identify a Twi1-related DNA nuclease(s) that carries out DNA elimination. I will use cutting-edge tools of single-molecule pull-down and multi-color FRET together with mass spectrometry. The nanoscopic understanding of a searcher (Twi1) and the identification of a nuclease will help create a new genome editing tool (e.g. a fusion of Twi1 and the nuclease) that potentially perform better than Cas9. Thereby, this fundamental study on “mighty RNA” will make a long-term impact for applications in science and technology. To realize this ambitious project, I will utilize my experience of studying small RNAs (funded by ERC Starting Grant).

Keywords: single molecule fluorescence,fret,genome editing,small rna,argonaute,microrna,crispr,cas9,rna interference,protein nucleic acid interactions
Deciphering the tEmperature history of troPIcal oceanS: a cOccolith clumpeD isotopE approach (EPISODE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Accurate climate modelling requires reliable estimations of climate sensitivity to CO2 forcing during past intervals of CO2 similar to those predicted. This entails an improvement of CO2 and sea surface temperature (SST) reconstructions, especially for tropical oceans. Widely-used paleothermometers such as UK’37, TEX86, foraminifer Mg/Ca and δ18O may not be accurate for absolute long-term SST in these regions. Therefore, coccolith clumped isotope thermometry (Δ47) is a promising tool to disentangle the especially problematic pre-late Miocene warm SST history of tropical oceans, improving our understanding of climate sensitivity and marine life to CO2 and allowing European and other countries to take wise and timely policy-related decisions and mitigation measures. This project aims to assess the presence of biological overprints (e.g. response to CO2 limitation) on coccolith Δ47 from cultures and coretop size fractions, develop an effective Δ47-SST calibration, validate the proxy by comparing Δ47-SST to a published reliable UK’37-SST record, and apply coccolith Δ47 to reconstruct absolute SST of Cenozoic tropical and polar oceans. This project combines the strong biological understanding of the proxy-encoding organism of the candidate and main supervisor, with the unique ability of the clumped isotope host group to achieve 1-2 °C precise Δ47 temperatures from 1-1.5 mg samples. This will allow to conclusively determine if there are vital effects in coccolith Δ47 and produce an unprecedented long-term tropical SST record for the pre-late Miocene. Implementing this project at the ETH Climate Geology group will enhance the candidate’s career via development of new scientific and analytical skills, while complementing and diversifying the research focus of the host group and enhancing Europe’s research excellence. To achieve highest impact, scientific peers, the local public, high school students and Europe parliamentarians related to climate change will be reached.

Keywords: coccolithophores,clumped isotope geochemistry,sea surface temperature,vital effects,carbon limitation,pre late miocene,earth system climate sensitivity
Sensors and daTA tRaininG towards high-performance Agri-food sysTEms (STARGATE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,France,Netherlands,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 899221.25
EU funding (EUR): 899221.25
Participants: 4
Project status: SIGNED

STARGATE will enable UCP to become an established centre of excellence on the use of sensors, multi-omics and plant phenotyping technologies as tools to gain a deeper understanding on the management of desired traits that enable sustainable and resilient agri-food systems. For this, it is essential that UCP increases its competencies in data management and data analysis. STARGATE will boost the level of excellence of UCP in a topic of extreme relevance to the centre’s core activities within its three pillars of research: Environment and Resources; Food and Nutrition; Biobased and Biomedical Products. The project will establish a framework upon which the Consortium will build to understand the potential impact of genetic resources and biodiversity on the final food, and to modulate plant phenotypes aiming to select the best raw material to generate the Premium food product (nutritious, healthy, safe and sustainable) by increasing resistance to biotic and abiotic stresses, reduce the use of fertilizers/herbicides, improve nutritional value of crops and overall quality, extend shelf-life and reduce losses. STARGATE will facilitate structural changes at UCP and maximize its high potential for research excellence by creating a synergic research environment with internationally leading institution in this area: INRAE, IPK and WR. These partners cover gap areas of UCP (sensing technologies, multi-omics, phenotyping, data analysis, predictive modelling). These centres have the infrastructure as well as the capacity to manage and analyse data generated by phenomics, metabolomics, diverse sensor data, and build predictive models for selected scenarios, being ideal to support UCP in acquiring such knowledge at international excellence levels. In the long term, STARGATE will enable UCP to expand these tools to other stages of the agri-food system and to develop a centre of excellence in high-performance agri-food systems.

Keywords: agri food systems,sensor technology,phenotyping,phenomics,metabolomics,farmers,modelling,machine learning,sustainability