Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electronic Doping of Soft Semiconductors (EDO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 3104687.0
EU funding (EUR): 3104687.0
Participants: 2
Project status: SIGNED

EDO will develop protocols for intentional, spatially controlled, and stable electronic doping in metal halide semiconductors. Electronic doping implies engineering of carrier density in semiconductors through the intentional introduction of a defect and it is necessary to achieve high performances in micro and optoelectronic technologies. Unlike established semiconductors, which are typically covalent solids, those belonging to the class of soft materials, such as molecules and polymers, forming van der Waals solids, and metal halide perovskites, forming ionic solids, host complex doping mechanisms. As a result, the design of free carrier density is far from being established and exploited in metal halides perovskites thin films. Intrinsic challenges, such as compensation and migration of defects, charge localization, phase segregation and the strong doping−processing relationship, may hide or hamper the designed doping process. Characterization and control of such phenomena require the combined knowledge of electronic, chemical and morphological/structural information, which is often missing. As a result, reports are often contradictory and advanced tools are in demand to draw a complete picture. Synchrotron facilities may help reaching the target, however, their limited access hampers direct feedback between synthesis and characterization. EDO will develop an unprecedent multimodal experimental tool, in laboratory environment, to quantitatively assess the doping and examine its impact on the optoelectronic properties of metal halides perovskites semiconductors. A photoemission microscope will be coupled to tunable coherent sources, covering the entire spectrum from NIR to soft X-ray radiation to map at nanometer scale the Fermi level shift, the electronic structure and the elemental composition and organization of thin films, and the relative optoelectronic dynamics, transferring the secured knowledge to the development of materials processing.

Keywords: defects,metal halide perovskites,optical and electronic spectroscopy and microscopy,optoelectronics
Gamma Radiation from the Atmosphere for Investigation and Learning (GRAIL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Armenia,France,Spain,Norway,Netherlands,United States,Serbia,Italy,Denmark,Germany
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 4645367.38
EU funding (EUR): 4524429.6
Participants: 17
Project status: SIGNED

Thunderstorms emit radiation across a spectrum from visible light to gamma rays, including terrestrial gamma-ray flashes and produce flickering gamma-ray flashes, thunderstorm ground enhancements and long-lasting gamma-ray glows which are the most energetic natural processes on Earth, with energies beyond those of radioactive decay chains as they appear in nuclear power plants. Sporadically observed since the ‘80s by aircraft and balloon platforms, by satellites, and on ground, these phenomena have been considered exotic and rare for decades. However, recent measurements have shown that high-energy emission is indeed common, pervasive and extended over huge areas, and that the phenomena are much more complex and inter-related than previously thought, posing new challenges. Despite their common nature, we are lacking fundamental knowledge about their generation and about their effects on humans, technology and the environment. The goal of the proposed Horizon Europe MSCA Doctoral Network is to gain a deeper understanding of high-energy emissions from thunderclouds, their relation to lightning and their effects. The consortium is built such that these phenomena are addressed through observations, numerical modelling and experiments. Additionally, we will develop new detectors suitable for future missions detecting such radiation in-situ or from space by building a consortium of international partners both academically and from industry. Hence, the GRAIL project combines innovative research and technological aspects providing a training environment for doctoral candidates in gas discharge physics, atmospheric electricity, modelling, data analysis and technological development. GRAIL has thus been designed to train the next generation of researchers and prepare them to be lead scientists in academia focusing on atmospheric electricity, and – through the incorporation of industrial partners – in industry interested in thunderstorms and lightning.

Keywords: lightning terrestrial gamma ray flashes gamma ray glows thunderstorm ground enhancements flickering gamma ray flashes thunderlouds
Stem and niche cell dynamics in normal and pathological conditions (STENIPATH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2499600.0
EU funding (EUR): 2499600.0
Participants: 1
Project status: SIGNED

Coherent tissue growth and repair require an interplay between stem cells and their local and systemic environment. The dynamics of this process remains poorly defined particularly at the intersection with disease. Cellular quiescence is adopted by many adult stem cells, conferring them several features including a smaller cell volume and reduced metabolic demand, suggesting that quiescence preserves stem cell properties making them less responsive to external cues. We examined the status of skeletal muscle stem (MuSC) and niche cells during an influenza virus infection (lung) and cancer cachexia (tumour) in mice. Unexpectedly, quiescent MuSCs remodelled their cellular, metabolic, and transcriptome properties extensively, and tissue regeneration was impaired, prompting us to define a novel cell state, GPath. Whether GPath represents a coordinated response of stem cells to pathology, or uncontrolled deregulation, is unclear. MuSCs exhibit remarkable diversity in gene regulation and function in distinct anatomical locations (head/limb). We discovered that cranial MuSCs display higher resistance to the pathologies compared to those in limb. These observations have led us into a novel area of research, to the best of my knowledge largely unexplored in model organisms and humans: how stem and niche cells in one organ respond to pathologies present at a distal site. We will examine the response of muscle and blood stem and niche cells to distal pathologies by defining their cellular, metabolic, molecular, epigenetic, and functional properties, and their modes of cell division. We will employ diverse multiomics approaches and novel medium/high-throughput intravital and ex vivo imaging pipelines. This work should provide new knowledge and tools to address an important, but under-investigated area of research where stem cell biology and pathologies converge. The knowledge gained will be widely applicable to other stem cell systems and inform on human pathologies.

Keywords: quiescence,muscle stem cells,influenza virus,cancer cachexia,symmetric and asymmetric divisions,intravital imaging mouse,regeneration,stem cell heterogeneity,gastruloids,craniofacial development
Quantum Control of Gravity with Levitated Mechanics (QuCoM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Netherlands,United Kingdom,Germany
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 2270149.94
EU funding (EUR): 2270149.94
Participants: 7
Project status: SIGNED

The main objective of QuCoM is to demonstrate the proof of concept (TRL 1) of a levitated acceleration sensor and its ability detecting gravity of small masses and in the quantum controlled regime. Toward this objective we will explore the interplay between quantum mechanics and gravity in a parameter range accessible for cost-effective table-top experiments. We will suspend sub millimetre particles in optical and magnetic traps and use those to detect gravitational forces in an unprecedented mass regime. Also, we will investigate quantum superpositions in which these masses are delocalized. We will address some of the most popular theoretical proposals combining quantum physics and gravity in a nonstandard fashion. The proposed experiments will assess their limits of validity and/or further constrain the values of their parameters. The consortium consists of two experimentalists, two theorists, and two SMEs to address the objective. The experiments in question will be performed with optically and magnetically trapped micro/nano-particles based on the experimental expertise of partners in the consortium. Levitated mechanics experiments at Southampton have been already picked up by the EU Innovation radar. In QuCoM we will, go beyond and demonstrate the two-mass gravity sensing as well as the operation of our sensors in the quantum domain. The state preparation, control and analysis schemes are based on the expertise of the theory partners. QuCoM partner high-tech SMEs will help to optimize the experimental apparatus for fulfilment of the targeted objectives, which will in turn put them in a position to offer their improved products in sub mK, low vibration cryogenic equipment to market. The SME LSI will explore, together with University of Leiden, the feasibility of implementing our technology into a micro-satellite platform for space-based metrology and Earth Exploration utilizing gravitational detection. This is our direct technology impact and innovation case.

Keywords: acceleration sensing,levitated nano mechanics,quantum optomechanics,quantum gravitation,quantum measurement,low temperature physics,vibration isolation
Women Migrants from the Northern Mediterranean and Work in Postwar Northwestern Europe (FeMMiWork)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1999996.0
EU funding (EUR): 1999996.0
Participants: 1
Project status: SIGNED

A key assumption about postwar migration in Europe is incorrect – that nearly all who moved from the European South to work in the booming northwestern European economies were men. In fact, anywhere between 25 and 30% were women, but their role was erased by policy-makers, and subsequently by researchers, who framed labour migration as male. The resulting epistemological fog has led to claims that the feminisation of migration is a recent phenomenon. Women’s work trajectories, and experiences of work, were distinctly gendered. Rectifying the record involves not only rescuing the forgotten stories of women working legally in factories. It also involves rethinking the notion of labour migration by focusing on invisible and informal, and yet crucial, labour, such as domestic work by women classified as dependents. By creating a counter-archive comprised of documents, oral history, and creative writing, this project will reconstruct the histories of women migrants. Four researchers will engage in systematic comparison of the trajectories and experiences of women from southern Europe (Italy, Yugoslavia) and Turkey, living and working in two destination states (France, West Germany) between 1955 and 1985. Using a transnational framework that considers relationships to multiple places, we will examine how gender and ethnic/national difference intersected to shape women’s experiences. By recognizing and analysing the central place of women from Southern Europe and Turkey in building the northwestern European economies in the postwar boom years, the study examines the genesis of what sociologists call “counter-geographies of globalization.” In de-centering European history by focusing on migrant women from Europe’s periphery, it will change our understanding of the evolution of Europe after the Second World War. Through interdisciplinary critical engagement, it promises to generate new insights into the evolving role of gendered labour in globalization processes.

Keywords: europe after 1945 migration history gender history guest worker programs informal work counter archives oral history transnational migration
Gap resolutIon in sAfety, NuTritional, alLergenicity and Environmental assessments to promote Alternative Protein utilization and the dietary Shift (GIANT LEAPS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Iceland,Ireland,Finland,France,Bulgaria,Germany,Portugal,Hungary,Poland,Serbia,Denmark,Switzerland,Canada,United Kingdom,Italy
Call: Filling knowledge gaps on the nutritional, safety, allergenicity and environmental assessment of alternative proteins and dietary shift (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 10347863.41
EU funding (EUR): 10272862.66
Participants: 35
Project status: SIGNED

Accelerating the transition from animal-based to alternative dietary proteins – the dietary shift – is key to reducing the footprint of our food system in terms of greenhouse gas emissions (GHG), energy, water and land use, and other relevant environmental impacts, and for improving the health and well-being of people, animals and the planet. GIANT LEAPS delivers the strategic innovations, methodologies, and open-access datasets to speed up this dietary shift, in line with the Farm-to-Fork strategy and contributing to the Green Deal target of reaching climate neutrality by 2050. Achieving the dietary shift in practice is inherently complex due to the diverse set of actors involved and further hindered by major knowledge gaps, scattered across the various alternative protein sources and the domains of health (safety, allergenicity and digestibility), environment (GHGs and other environmental and climate impacts, biodiversity, circularity), and/or barriers to adoption (technological, sensory, and consumer acceptance). The GIANT LEAPS consortium consists of the key actors and spans all expertise to address relevant knowledge gaps and proactively engages to arrive at optimized future diets based on alternative proteins that are broadly accepted across stakeholder groups. In order to deliver required insights for short-, mid- and long-term decision making and impact, GIANT LEAPS protein sources have been selected for either targeted or full assessment based on their current level of specification. The innovations and improved methods combined with accessible and comprehensive information, generated for a wide collection of alternative proteins, will enable policymakers to prioritise changes in the food system towards the dietary shift based on desired impact, value chain actors to make strategic scientific, business and investment choices, and the general public to make more sustainable and healthy dietary choices.

Keywords: allergenicity,protein,sustainability,food policy,food systems,biodiversity,digestibility,bioavailability,diet,circularity,consumer science,novel foods,protein transition,food processing
Disordered Metal-Organic Frameworks for Drug Delivery (DrugMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Drug delivery systems are often needed for delivering drugs in a targeted organ or tissue at a desired concentration range and without toxic side effects. Metal-organic frameworks (MOFs) have emerged as promising drug delivery systems due to their high loading capacity, but currently this is also their main limitation as it results in too rapid drug release in the human body, causing an excessive response and potentially toxic side effects. Slowing down the drug release rate, while maintaining high loading capacity and biocompatibility, would enable applications within especially cancer therapy. Disordered MOFs (i.e., MOFs without an ordered crystalline structure) have smaller pores and more torturous pathways for drug release. The project’s proposed strategy is to load anti-cancer drugs in the crystalline MOF with high surface area and thus high loading capacity and then subsequently subject this material to an order-to-disorder transition, giving rise to slower drug release. This transition can be induced by either mechanical ball milling or thermal melt-quenching. Molecular dynamics and classification-based machine learning will be used to identify which local atomic structures are best correlated with drug release rate in disordered MOFs. Experimental validation will be performed to establish design principles for MOF structures with a tailored drug release profile. The project builds on complementary expertise of the fellow applicant (disordered biomaterials, in vitro studies) and supervisor (MOFs, simulations, machine learning). Combined with the research and training environment offered by the host organization (Aalborg University, Denmark), this will ensure the achievement of this novel project as well as the dissemination and exploitation of the results. The goal is to develop principles for designing disordered MOFs for drug delivery. The fellow applicant will emerge from the project with new skills, and the capability to launch his own research group.

Keywords: drug delivery,metal organic frameworks,glasses,molecular dynamics,machine learning,structure property relations
CrowdControl: Identifying the mechanism underlying intracellular density homeostasis. (CrowdControl)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 332506.56
EU funding (EUR): 332506.56
Participants: 2
Project status: SIGNED

The cytoplasm is filled with an extremely high concentration of macromolecules that is close to the maximal physical limit. Such a tight packing of macromolecules gives rise to a crowding effect that influences chemical reactions and protein dynamics. Changes in crowding levels are therefore predicted to have profound consequences on cell function. It is therefore not surprising that the overall intracellular concentration of macromolecules is very constant within a cell type, but it varies during important physiological transitions such as cell division, differentiation, and senescence. How crowding is regulated is poorly understood but feedback coupling between intracellular density and cell growth has been observed in multiple systems. The CrowdControl project will combine two unbiased screening approaches with targeted genetic manipulations and quantitative live cell imaging to identify the molecular mechanism underlying intracellular density homeostasis. Specifically, we will: (i) identify proteins that can sense intracellular density changes by performing structure sensitive mass spectrometry in cells with different levels of macromolecular crowding; (ii) perform a CRISPR-knockout screen to identify mutations that affect density homeostasis; and (iii) use quantitative live cell microscopy to investigate whether proteins identified in (i) and (ii) affect feedback coupling between intracellular density and cell growth. A better understanding of intracellular density regulation will allow the development of precise tools to alter crowding and identification of crowding sensitive proteins will give insight into what processes may respond to density changes. The results of this project will therefore be key to understanding how cells finely tune their intracellular density levels, but in addition they will also lay the basis for understanding how density changes affect cell function during the cell cycle, senescence, and differentiation.

Keywords: crowding,intracellular density,overall macromolecular concentration