Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Adopting orphan pumps: Structural and functional characterization of P5-ATPases (hyP5)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

P5-ATPases are conserved in all eukaryotes and malfunctions in human are associated with severe neurological diseases, such as familial early-onset parkinsonism and autism/language disorders, and with phenotypical traits in yeasts. They belong to the P-type ATPase superfamily, which encompass a range of essential membrane transporters for ions and lipids. Ion pumps such as Na,K-ATPase and Ca2+-ATPase have been studied in great detail during the last decades. However, astonishingly little is known about the P5-ATPases and their actual function, despite their physiological importance in all eukaryotes. The current proposal focuses on substrate identification and structural characterization of P5-ATPases, as well as investigations of their cellular interaction network. Human P5-ATPases (ATP13A1 through 5, ATP13A2 also known as PARK9) and the yeast orthologues Spf1p and Ypk9p will be subjects of this study. Target proteins will be expressed in their native host (yeast or HEK cells) and subsequently purified and used for activity assays, structural studies, and identification of interaction partners. Native mass spectrometry will identify bound substrates and cofactors, and activity studies will elucidate structure-function relationships. 3D-structures obtained by single-particle cryo-electron microscopy (cryo-EM) and/or X-ray crystallography will reveal catalytic mechanisms and mutational effects. Structural and functional characterization of P5-ATPases can therefore serve as a basis for understanding molecular mechanisms of e.g. neurodegenerative and cognitive disorders and guide novel strategies in disease treatments and drug discovery. Using my profound experience from my PhD with crystallography of biotechnologically relevant proteins, I wish to pursue a postdoc focused on membrane proteins with a strong potential in molecular medicine and to expand my knowledge of methods in structural biology and molecular cell biology, in particular cryo-EM.

Keywords: membrane protein,p type atpase,cryo em,parkinson s disease,lysosome
Realigning British Romanticism: White Settler and Indigenous Writing in the British-Controlled Southern Hemisphere, 1783-1870 (SouthHem)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1487938.0
EU funding (EUR): 1487938.0
Participants: 1
Project status: CLOSED

SouthHem is a five-year research project designed to rethink and realign the nature and scope of British Romanticism by giving settler and indigenous literatures produced in the British-controlled Southern Hemisphere a more central role in defining the literary culture of the period 1783-1870. The project will carry out, for the first time, a detailed comparative analysis of these literatures and their interactions with British Romantic writing by focusing on case studies of encounter and transculturation in three transnational zones: “Zone 1” (Oceania): Australia and New Zealand; “Zone 2” (Southern Africa): the Cape Colony and Natal; and “Zone 3” (South-East Asia): Singapore, Java, and Malacca. The project has three inter-related aims: first, to consider the reciprocal transformations of literary themes, genres, standards, and forms in the British-controlled Southern Hemisphere and Britain; second, to rethink the ways in which nationhood, nationalism, and, in particular, national literature emerged in Britain and elsewhere by considering the global origins of nationalism; and third to problematise traditional periodisations of British Romanticism as beginning in the 1790s and ending in the 1830s. By radically expanding the type, provenance, and sample size of texts typically considered in studies of British Romanticism, this project will not only result in an important geographic, temporal, and conceptual rethinking of the field, but it will also provide a better understanding of how literary modernity emerged and developed outside of Europe and the Northern Hemisphere. As such, the project will facilitate larger cross-imperial and synthetic studies of the indigenous and settler literatures of the period.

Keywords: british romanticism,southern hemisphere,transnational,comparative,imperialism,nationalism,modernity,postcolonialism,indigenous literatures,white settler communities
Long-range coupling of hole spins on a silicon chip (LONGSPIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-12-31
Duration (months): 70.0
Total project cost (EUR): 1998423.0
EU funding (EUR): 1998423.0
Participants: 1
Project status: SIGNED

With the miniaturization of electronic devices, the semiconductor industry has to deal with complex technical barriers and is forced to introduce novel and innovative concepts. The project proposal is exactly in line with this new paradigm as it proposes to divert CMOS technology to explore a new path for quantum spintronics. Concretely the project aims at using spin-orbit interaction present in the valence band of silicon to drive ultra-fast and ultra-coherent hole spin quantum bits (qubits). The proposal builds on the first demonstration by the principal investigator of a hole spin qubit electrically driven in silicon. While spins are excellent quantum bits, their long-range coupling remains a challenge to tackle towards complex quantum computing architectures. Here I propose to take up this challenge using a microwave photon as a quantum mediator between qubits in silicon. The LONGSPIN project presents a unique approach by leveraging a standard silicon-on-insulator CMOS process for the implementation of the qubits co-integrated with superconducting microwave resonators. This research project will provide a CMOS quantum toolkit with optimized designs and materials for fast and coherent qubits with a profound understanding of the physical limitations to hole spin coherence and hole qubit gate fidelity in silicon. Eventually a microwave photon used as a quantum bus will allow the transfer of quantum information between distant spin qubits.

Keywords: quantum dot,spin qubit,cmos technology,silicon,superconducting microwave resonator
Smart Ski (Smart Ski)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Slovenia
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Smart Ski is a new breakthrough in ski industry, first after the introduction of carving concept in 1990s, which was also initiated by this same project team. Smart Ski is an IT-based pair of skis. Its sliding properties, driveability and bottom surface friction can be managed by skier via smart phone, according to his/her skiing skills, weather and ski terrain. This results in all-in-one ski, for all types of skiers. Smart Ski can also fold, so it is much less bulky. Such customization directly eases users' problems with limitation - of rigid current ski solutions, and of storage space. In future, safety and software functions will be added. Commercial potential is global - the main objective is to push through a new skiing revolution. That's why we won't develop our own commercialization, but will rather sell license to big 6 market leaders with existing sales and marketing channels, brands and global presence (Atomic, Rossignoll, Fischer, Elan, K2, HTM). First feedbacks for our prototype by their R&D departments were very positive. Some even estimated that embracing our solution will reduce their ski production costs by 30% and increase recyclability of production waste to 80%, in comparison to current state of the art. Our model also enables them to keep their brands, graphic designs, etc., and only buy know-how. This is a direct trigger for market leaders to form win-win partnerships with us. Smart Ski thus directly responds both to end-user needs, and to targeted buyers' needs. We estimate to realize 23 mio € revenue in first 5 years through license transfer fee, fee for each sold pair of skis, and component sales. In the feasibility study we need to 1-finish testing and developing of prototype, 2-develop in-depth market study with end-user aspects, 3-activate marketing channels and negotiate with market leaders, 4-study future financial models and contribute to business plan chapters. Our innovation project needs one last push to commercialization.

Keywords: innovation,ski industry disruption
Graphene Tunneling Accelerometer (GraTA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-08-01
End date: 2018-07-31
Duration (months): 12.0
Total project cost (EUR): 149858.0
EU funding (EUR): 149858.0
Participants: 1
Project status: CLOSED

The commercialization of existing tunneling accelerometers is hindered by their complex fabrication and long-term instability. Based on our results and expertise from the currently running ERC project, we propose an innovative design using graphene as the game-changing material for tunneling accelerometers. The proposed graphene tunneling accelerometer has clear technical advantages, such as smaller size, wider bandwidth, simpler fabrication, and natural stability. A careful patent search indicates that the concept is novel for patent protection. Our industrial contacts have clear interest in this innovation, detailed user requirements on the accelerometer specifications have been recently mapped up. We have a capable team and a feasible plan towards the real-life commercialization of the proof-of-concept innovation. The output of the project is expected to be a long-pursued efficient application of graphene in high-end sensors. Continuity of the development and commercialization is strongly considered also after the project funding.

Keywords: graphene,tunneling,nems,accelerometer
Toolbox of multipotent bioactive composite implants for the full functional regeneration of bones after a trauma (REBOOT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: France
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are 8 million bone trauma each year in the EU alone, affecting mostly active people and about 1 million children. 20% of all bone injuries require hospitalization and cost ~2 billion euro to healthcare payers each year. Biomaterial fixation implants are used today to heal these people’s bones but none of them can guarantee their full functional restoration. Implants always leave a mark: a hole, a foreign material (the case of metallic devices) or poor restored functionality (the case of absorbable polymer and recent composite implants). Second surgery is even needed in nearly one third of the cases. As population ages, finding materials to enable citizens to live a longer active life with a strong, well-preserved bony structure is a top priority. In this context, the biomaterial company NORAKER has developed the first bioactive composite fixation implant made of a well-tolerated absorbable polymer combined with a revolutionary synthetic biomaterial able to form bone, where it is missing : bioactive glass. This implant, which addressed the fixation of the anterior cruciate ligament in the knee, showed bone-rebooting performances well above the state-of the-art. Major stakeholders (surgeons, hospital, specialized distributors worldwide) have been urging NORAKER to develop further implants to address a wide spectrum of bone trauma (fracture, tendon rupture). This persisting demand has convinced NORAKER to develop a full bioactive composite implant toolbox. To meet this goal, NORAKER will : - Validate the feasibility of the bioactive composite formulation to target all bone trauma and to design all associated implants - Determine the first implants to populate the toolbox (outcome of a user and market study) and gain visibility to early-adopters - Establish a robust business model to market the toolbox straight forward at the global scale. This is the scope of the project REBOOT.

Keywords: bioactive composite,bioactive glass,new formulation,bone fixation implant,orthopaedics,implant,toolbox
Fostering the adoption of GALILEO for Mobility as a Service (GALILEO 4 Mobility)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Greece,Belgium,France,United Kingdom,United Kingdom
Call: EGNSS mass market applications (H2020-GALILEO-GSA-2017-1, 2017)
Start date: 2017-11-01
End date: 2020-06-30
Duration (months): 32.0
Total project cost (EUR): 2740483.75
EU funding (EUR): 2235010.0
Participants: 11
Project status: CLOSED

GALILEO 4 Mobility aims at supporting the introduction of GALILEO technology within the Mobility as a Service context, by analysing the needs in terms of geolocation of the different stakeholders involved and demonstrating the benefits of GALILEO through pilot demonstrators of shared mobility services. Urban mobility is becoming an issue of great importance in today’s society due to the increasing population movements towards big cities and the exponential growth of cities in developing countries. Today, urban mobility schemes are evolving faster than ever mainly due to social, economic and technological changes. The democratization of smart mobile devices is allowing new business models based on sharing goods and services: the sharing economy. Its fast growth during recent years reflects a shift from owning goods toward accessing them when you need them. In that context, shared mobility services have grown exponentially during last years, with the potential to become an integrated system of multi-modal mobility services: the so-called “Mobility as a Service” (MaaS). Geolocation of users and vehicles by means of satellite navigation technologies has been widely used and it´s a key enabler for most of the services. While traditional GPS-based solutions have proven not to be a reliable solution, GALILEO will further improve signal availability, thus enhancing continuity of service for shared mobility services in urban or challenging environments.

Keywords: transport,mobility as a service,shared mobility
Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions (SIMIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Superfluids violate our classical intuition, provoking many intriguing questions in modern condensed matter physics. In particular, superfluid phases with non-standard pairing mechanisms, which play an essential role in diverse physical systems including high-Tc superconductivity, have attracted great interests, and the underlying principles challenge our understanding. Ultracold atomic systems have emerged as an ideal testbed for simulating such many-body states by directly comparing theories with experiments. Recently, the host group has achieved a novel mass-imbalanced Fermi-Fermi mixture, which offers unprecedented opportunities to realize unusual superfluid phases. Here, we propose experimental studies on unconventional superfluidity by exploiting the excellent controllability in our new quantum system. Mass imbalance changes how the two Fermi surfaces overlap, causing the pairs to have finite momentum and resulting in a rich phase diagram. We aim to explore many-body phases appearing in a mass-imbalanced Fermi-Fermi mixture near the strongly interacting limit. To demonstrate superfluidity, we will probe the atoms by magnetic and optic methods, which allow distinguishing between pairs and unpaired atoms. Moreover, we will investigate the superfluid shell structure in a trapped system to characterize the phase diagram and the thermodynamic properties in the strongly interacting regime, based on tomographic imaging. Finally, we plan to extend our methods to search for exotic forms of superfluidity such as supersolid or gapless phases. Our research will open a new chapter of condensed-matter simulation with ultracold atoms by providing a unique platform to study unconventional superfluidity. The successful demonstration will have strong impact on the scientific community even beyond the field of quantum gases. The techniques applied in this project can be further developed to address many other interesting topics such as impurity physics and transport dynamics.

Keywords: bec bcs crossover,fermi fermi mixture,inhomogenous superfluid,supersolid
Room Temperature Magnetic Resonance Force Microscopy (RTMFRM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-08-01
End date: 2021-05-31
Duration (months): 22.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Magnetic resonance imaging (MRI) enables three-dimensional images to be created in a non-destructive and safe manner. Mechanical resonators can greatly increase the sensitivity of MRI compared to commercial systems. Considerable effort is being expended to push magnetic resonance imaging down to single atom resolution. This is currently done by applying large-amplitude magnetic pulses at milliKelvin temperatures. However, these large-amplitude pulses generate heating, creating a roadblock for reaching single atom resolution. Here, we propose a completely new approach to carry out magnetic resonance force microscopy at room temperature. This is expected to eliminate the effect of the “heating” roadblock, opening a new route to achieving MRI with single-atom resolution.

Keywords: nanomri,nuclear spin,mechanical resonators,carbon nanotube
Mesoscale holographic interrogation of visual circuits mediating predictive coding (HoloPredict)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 257173.44
EU funding (EUR): 257173.44
Participants: 2
Project status: CLOSED

Predictive coding is an attractive framework to understand sensory processing. However a direct experimental demonstration of this unique capacity of the brain to sensory representations has been lacking, essentially because of the difficulty to separate between external and self-generated representations using correlative or causal paradigms. Similarly, the neural circuits underlying predictive coding in the context of sensory perception have been largely unexplored, primarily because of technological bottlenecks to image and manipulate selected neurons within neural circuits extending multiple areas. In this proposal, I aim to develop a mesoscale two-photon holographic technology that will enable the manipulation of functionally selected neurons in targeted higher visual areas, while simultaneously measuring neural activity throughout the cortical visual hierarchy. This will allow to test primary hypotheses related to the predictive coding framework in the context of visual processing. Importantly, it will provide the possibility for the direct demonstration of predictive coding in the visual cortex by artificially generating an internal sensory representation from scratch in a behaving awake animal. Finally, I use will use this powerful technology to investigate the neural circuits underlying top-down predictive coding with a precision and scope unattainable so far.

Keywords: multiphoton optogenetics,non linear microscopy,systems neuroscience,sensory processing,visual cortex