Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Industrial optimal design using adjoint CFD (IODA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Germany,Italy,Greece,Belgium,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3854909.52
EU funding (EUR): 3854909.52
Participants: 10
Project status: CLOSED

Adjoint-based methods have become the most interesting approach in numerical optimisation using Computational Fluid Dynamics (CFD) due to their low computational cost compared to other approaches. The development of adjoint solvers has seen significant research interest, and a number of EC projects have been funded on adjoint-based optimisation. In particular, partners of this proposal are members of the EC FP7 projects FlowHead and AboutFlow which develops complete adjoint-based design methods for steady-state and unsteady flows in industrial design. Two related bottlenecks of applying goal-based optimisation in CFD are addressed here a) the efficient but flexible and automatic parametrisation of arbitrary shapes, and b) the imposition of design constraints. Parametrisation is at the core of optimisation, it defines the design space that the optimising algorithm is exploring. A range of parametrisations will be developed in the project, ranging from simple CAD-free methods with rich design spaces to CAD-based methods that return the optimised shape in CAD form. Integration of the currently available shape and topology modification approaches with the gradient-based optimisation approach will be addressed, in particular development of interfaces to return optimised CAD-free shapes into CAD for further design and analysis, an aspect that currently requires manual interpretation by an expert user. Constraints are at the core of industrial design, e.g. an optimised climate ducts for a vehicle needs to fit into the available build space. The project will develop efficient ways to extract constraints specified in the CAD model and apply them to CAD-free parametrisations. Methods will be developed to quantify how much the limited design space impairs the optimum and then to adaptively refine it. The results of the project will be applied to realistic mid-size and large-scale industrial optimisation problems supplied by the industrial project partners ranging from

Keywords: computational fluid dynamics,adjoint methods,gradient based optimisation
Multiscale modelling of stimuli-responsive nanoreactors (NANOREACTOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1987500.0
EU funding (EUR): 558437.5
Participants: 2
Project status: CLOSED

The catalysis by metal nanoparticles is one of the fastest growing areas in nanoscience due to our society's exploding need for fuels, drugs, and environmental remediation. However, the optimal control of catalytic activity and selectivity remains one of the grand challenges in the 21st century. Here, I propose to theoretically derive design rules for the optimization of nanoparticle catalysis by means of thermosensitive yolk-shell carrier systems. In the latter, the nanoparticle is stabilized in solution by an encapsulating, thermosensitive hydrogel shell. The physicochemical properties of this polymeric 'nanogate' react to stimuli in the environment and thus permit the reactant transport and the diffusion-controlled part of the catalytic reaction to be switched and tuned, e.g., by the temperature or the pH. The novel hybrid character of these emerging 'nanoreactors' opens up unprecedented ways for the control of nanocatalysis due to new designable degrees of freedom. The complex mechanisms behind stimuli-responsive nanocatalysis call for a concerted, interdisciplinary modelling approach that has converged in my group in the recent years. In particular, it can only be achieved by combining my expertise in multiscale computer simulations of solvated polymers with the statistical and continuum mechanics of soft matter structures and dynamics. The key challenge is to integrate the molecular solvation effects and our growing knowledge of hydrogel mechanics and thermodynamics into advanced reaction-diffusion equations for a quantitative rate prediction. In addition, I envision exciting novel phenomena such as a chemo-mechanical 'self-regulated catalysis' or an amplifying 'resonant catalysis', if hydrogel response and fluctuations couple to the chemical output signal. The expected results and design principles will help our collaborators to synthesize tailor-made, superior nanocatalysts and will advance our understanding of their structure-reactivity relationship.

Keywords: diffusion controlled reaction,nanocatalysis,thermosensitive hydrogel,molecular transport and kinetics,solvophilic,phobic solvation,computer simulation,reaction diffusion equation,smart material
Somatic and Germline Mechanisms of Small RNA Inheritance (RNAiNHERITANCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1997150.0
EU funding (EUR): 1997150.0
Participants: 1
Project status: SIGNED

Inherited information is transmitted to progeny primarily via the genome through the gametes. In recent years, epigenetic inheritance has been demonstrated in several organisms, including animals. Yet, the molecules and mechanisms responsible for this type of inheritance are incompletely understood. Histone modifications, DNA methylation, and small RNAs have been proposed to participate in epigenetic inheritance. Indeed, we recently showed how the inheritance of a specific type of small RNA impairs animals’ fertility. Diverse phenotypes, such as immune responses and learned behaviour, were also recently found to be controlled by heritable small RNAs. Despite these important roles for small RNAs in trait inheritance, their mechanism of action and how they are transmitted from tissues and gametes to the next generation remain unknown. The overall objective of this proposal is to discover novel factors and mechanisms that underlie epigenetic inheritance in animals. The nematode Caenorhabditis elegans is an ideal model system to study epigenetic inheritance, because of its short life cycle and the ability to minimize the effect of genetic variations. We will achieve our objective by applying genetic, genomic and biochemical tools to C. elegans, coupled with sophisticated sorting strategies developed in our laboratory. These approaches uniquely allow us to comprehensively evaluate small RNA inheritance in specific stages of development, tissues and organelles. Specifically, we will 1) elucidate how small RNAs and histone modifications regulate the inheritance of developmental programs, 2) decipher the mechanisms of small antisense RNA biogenesis and inheritance, and 3) discover the principles of soma-to-germline RNA transfer and its biological functions. Achieving our objective could radically change concepts of inheritance, and transform our understanding of the molecular pathways and mechanisms that govern epigenetic inheritance in animals.

Keywords: epigenetic inheritance,small rnas,transgenerational epigenetic inheritance,rnai,gene regulation
INcreasing Safety in NPPs by Covering gaps in Environmental Fatigue Assessment (INCEFA - PLUS)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Switzerland,Belgium,Finland,Lithuania,France,France,Czechia,United Kingdom,United Kingdom
Call: Improved safety design and operation of fission reactors (NFRP-2014-2015, 2014)
Start date: 2015-07-01
End date: 2020-10-31
Duration (months): 64.0
Total project cost (EUR): 6140668.75
EU funding (EUR): 2550128.0
Participants: 17
Project status: CLOSED

INCEFA-PLUS delivers new experimental data and new guidelines for assessment of environmental fatigue damage to ensure safe operation of European nuclear power plants. Austenitic stainless steels will be tested for the effects of mean strain, hold time and material roughness on fatigue endurance. Testing will be in nuclear Light Water Reactor environments. The three experimental parameters were selected in the framework of an in-kind project during which the current state of the art for this technical area was developed. The data obtained will be collected and standardised in an online fatigue database with the objective of organising a CEN workshop on this aspect. The gaps in available fatigue data lead to uncertainty in current assessments. The gaps, will be targeted so that fatigue assessment procedures can address behaviour under conditions closer to normal plant operation than is currently possible. Increased safety can thus be assured. INCEFA-PLUS also develops and disseminates a modified procedure for estimating environmental fatigue degradation. This will take better account of the effects of mean strain, hold time and surface finish. This will enable better management of nuclear components, making possible the long term operation (LTO) of NPPs under safer conditions. INCEFA-PLUS is relevant to the NFRP1-2014 programme because: • Present guidance originates from NRC. In Europe various national programmes aim to develop counter proposals allowing greater operational efficiency with at least comparable safety assurance. INCEFA-PLUS brings these programmes together through which a strong EU response to the NRC methodology will be obtained with improved safety assurance through increased lifetime assessment reliability. • INCEFA-PLUS improves comparability of data from EU programmes because partner laboratories will do some tests on a common material under common conditions. Reduced assessment uncertainty will enable easier maintenance of safety

Keywords: environmental fatigue
Coupling Quantum Emitters to Graphene Plasmons: a new route towards fast Quantum Optics (E-GRA-MONS OPTICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

E-GRA-MONS OPTICS aims to couple quantum emitters (e.g. quantum dots and endohedral fullerenes) to the strong electric fields of graphene plasmons with the ultimate goal of performing fast quantum operations in the near infrared and visible spectrum. Such an integrated system will overcome the low processing speed of atoms and photons, thus providing a robust, solid-state platform for fast quantum optics. The real challenge is to integrate the features of quantum emitters and graphene plasmons into a single functional nanomaterial, understanding how the interactions at the nano-scale can impact its optical properties. To meet this challenge, this project adopts a multidisciplinary approach, combining the applicant’s experience in quantum operations using atoms and photons in conjunction with the world-leading expertise of the host organization in nanoscience and nanotechnology. The main objective is the experimental demonstration of strong emitter-plasmon coupling and plasmon-mediated interactions between emitters, which will be the fundamentals of novel quantum-optics technologies

Keywords: graphne plasmonics,colloidal quantum dots
Nanobody-enabled Structural Investigation of a G Protein-Coupled Receptor-Arrestin Complex (NESIAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Although many thousands of transient protein-protein interactions (PPIs) are known, there is a disturbing paucity of high-resolution structures of the resulting complexes and the difficulties involved in experimentally determining these atomic structures remain essentially unaddressed. The Steyaert lab has shown that cross-linking transiently interacting proteins, followed by immunization of llama’s with this cross-linked antigen, causes the maturation of single domain antibodies called Nanobodies (Nbs). The Nbs bind composite conformational epitopes unique to the transient complex. Highly efficient selection methods can discriminate Nbs that exclusively bind the transient (non-cross-linked) complex from binders that bind to the dissociated monomers. Such Nbs will be instrumental to purify and solve the structures of PPIs that have been resistant to investigation by X-ray, NMR, SAXS or EM and for the functional analysis of these complexes within a living cell. This ground-breaking technology will be validated with well-chosen case studies covering key PPIs of the GPCR transmembrane signaling pathway including parts of the arrestin interactome. During this project the fellow will establish a unique research niche by systematically applying her arsenal of learnt techniques to develop the next generation antibody‐enabled methods for the structural investigation of the GPCR-arrestin targets. The ultimate goal of NESIAC is to determine the atomic structures of the most relevant transient associations of these signaling proteins. This will open up a new platform for realising the structural basis of the elusive GPCR regulation by arrestins.
New BAMboo ENGineered bio-material for sustainable building components (BAMBENG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our proposed technology uses bamboo for manufacturing a unique new bio-material which has the potential to replace most commonly used structural materials such as concrete, steel and timber. This novel process will not only ensure the sustainable supply of raw materials via environment friendly new solution in construction industry, but will also provide participating SME with the opportunity to derive an ongoing income. BAMBENG proposal outlines the opportunity to develop an innovative technological process which will produce a new constructional product, chemical free and environmental friendly (avoiding the use of toxic and polluting glues) with supreme technological, economic and environmental footprint performances. That would make BAMBENG advantageous competitor and feasible alternative as BAMBENG structural material, represents the best performing material for supporting structure for seismic building. BAMBENG is obtained by a simple chafing and pressure welding process, producing a semi-finished completely biological new component. The process in chemical free, energy saving and with a very low footprint, Compared with the most direct and similar competitive materials (wood, glulam and glubam) BAMBENG offers better technical performances and up to 45% of cost savings (based on Cost Structure Analysis). BAMBENG is worth to invest in because it is a combination of proven technology and novel application of demonstrable technology and methods which have both economic & environmental benefits: - Development of bigger structural components for buildings sector for easy substitution of current material like steel, aluminium, concrete, and even timber, - Development of building design to exceed seismic and hurricane requirements, - Transfer to other sectors such as interior and exterior architectural, packaging and design artefacts, - Improvement of local bamboo crops at EC level, and - Potential to license the technology to SMEs throughout the EU.

Keywords: engineered bamboo,bio material,construction,wood
Energy from Limited Velocity Estuaries and Rivers (ELVER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

An accelerated adoption of renewable energy generation is needed to meet the ambitious but necessary goals for low-carbon economy set by the European Commission (80% reduction from 1990 greenhouse emissions to 2050), and the G7 (elimination of fossil fuel generation to 2100). Despite good progress, it is still difficult to create a stable renewable energy generation mix, and to provide solutions that can reach all locations and communities in Europe, including remote communities. Significant parts of rivers worldwide remain an untapped energy resource, due to the lack of appropriate technology for hydro power extraction from remote/environmentally sensitive locations, or those with low-head, current velocity, or depth. Eel Energy, a French hydrotech startup, has developed a 1MW tidal energy converter based on biomimetic principles. Eel’s solution is an undulating membrane producing energy via linear converters, which significantly outperforms turbine-based technology in terms of simplicity, reliability, efficiency and environmental footprint. Eel Energy is now developing the ELVER (baby eel), a small (80kW), riverine-adapted version of their tidal generator. Compared with standard turbine solutions, ELVER will be able to reach higher efficiency and reliability, operate at lower heads and current velocities, and require far less civil works: reducing installation, operations costs, and environmental impact of installation. This technology has an unprecedented range of potential installation sites, and can play an important part in the sustainability of rural/remote communities. ELVER allows the development of new hydrokinetic resources, in both mature markets, and the developing world. In phase 1 of ELVER (6 months), we will characterise and quantify the riverine resources and the key advantages. Secure commercial trials locations, partners and funding for phase 2, and enhance our technical roadmap, roll-out strategy, commercialisation plan, and IP strategy.

Keywords: hydropower,tidal energy converter
Politicians’ traits and public policies: learning how personal features influence fiscal outcomes (POLITRAITS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Nowadays there is little doubt that maximizing social welfare is not the sole goal of policymakers. Policy choices such as the level of taxation and spending are at the core of public economics. A positive approach to this field takes into account the fact that budgets and policies are set by political agents who are office-seekers. Early studies on political economy have focused on institutional factors, voters’ preferences, interests groups, and party ideology as major drivers of public policies. But a growing number of theoretical and empirical studies have started to examine the particular features of political leaders (e.g. gender or ethnicity) as relevant determinants of economic outcomes and policies. This project seeks to contribute to the understanding of how the individual traits of politicians affect public policies. This approach shifts the focus of attention from political parties to individual legislators. In examining the impact of parties on policies, studies often treat parties as homogeneous units. In contrast, this project takes into consideration the heterogeneity of its members in several dimensions. In particular, this project revolves around two topics. First, the politician‘s loyalty to her political party and its impact on public spending. A legislator may be reluctant to follow the party line if this generates a conflict with her constituents’ interests. To foster loyalty, parties may use discretionary spending targeted at specific districts. The second topic is the level of education of politicians. This project examines the possibility that education is not only a reflection of the level of skills but it acts as a dimension of political representation.

Keywords: political economy,government spending,public policies,fiscal outcomes,party discipline,politicians education