Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanocrystalline Permanent Magnets Based on Hybrid Metal-Ferrites (NANOPYME)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Spain,Italy,Norway,Denmark,Slovenia,Denmark,Germany,Spain
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 4506353.54
EU funding (EUR): 3479493.0
Participants: 12
Project status: CLOSED

This project addresses the design and development of permanent magnets without rare earths but consisting on hybrid nanostructures based on metals and metal ferrite oxides. The metallic nanostructures offers high magnetization values while the ferrite oxide one provides high anisotropy. We intend to design and process novel permanent magnets based on traditional hard ferrites and additional new magnetic phases combined with a soft magnetic phase to achieve high magnetic performance through effective exchange-coupling of both magnetic phases. This phenomenon has been extensively studied in metallic systems but not in oxide nanocomposite permanent magnets, where the studies are very scarce mainly due to the difficulty in optimizing the magnetic properties because of microstructural complexities. In view of practical applications this will guarantee their use in some nowadays applications which are currently covered by more expensive rare-earth permanent magnets, simply because typical ferrites do not fulfill the required magnetic energy product. This “no-man's-land” applications area - characterized by required energy products between 35 to 100 kJ/m3 - includes fundamental fields such as diverse components for transport and energy applications. As an important consequence, the use of rare-earth based permanent magnets will be reduced to its maximum possible extent by fulfilling the needs for a broad applications range by these newly designed rare-earth free permanent magnets. This project is therefore important from a fundamental as well as from a practical point of view where the complementary expertise areas of the different groups will combine to achieve the proposed objectives.

Keywords: permanent magnets,nanocomposites,ferrites,metals,exchange-coupling
Signal Amplified Biosensing by Chemical Catalysis (CATALYTICBIOSENSING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2011-PoC, 2011)
Start date: 2012-04-01
End date: 2013-03-31
Duration (months): 12.0
Total project cost (EUR): 168224.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In this project we will develop a broadly applicable signal amplification system that relies on chemical catalysis for biosensing purposes. In preliminary experiments it was demonstrated that the functionalization of two oligonucleotides with triphenyl phosphine ligands and their hybridization on a target DNA strand produced a very efficient catalyst for the dehalogenation of an iodinated boron dipyrromethane (BODIPY) dye. The removal of the iodine transforms the non-fluorescent chromophore into a highly fluorescent dye. In this way, a single hybridization event results in more than 1000 fluorescent reporters and extremely low detection limits of 10 fM were successfully realized. Herein it is planned to extend this concept of signal amplification to commercially relevant technologies like Enzyme Linked Immunosorbent Assays (ELISAs) or DNA microarrays. For that purpose different ligands will be synthesized and the reactivity as well as the spectral range of the BODIPY reporters will be varied. These experimental efforts, therefore, represent a broadening of our existing proof of concept experiments. Besides this experimental work, we will write up a business plan to commercialize our technology and receive further funding like seed grants or venture capital. There is a strong need in the in vitro diagnostic industry to fabricate improved analytical tests to detect new disease markers at low concentrations. With the catalytic signal amplification system several of these needs can be fulfilled. Due to the broad applicability of our technology platform it is envisioned to found a spin-off company that acts as service provider for the diagnostic industry.

Keywords: 240080
Sustainable Technologies for Calcined Industrial Minerals in Europe (STOICISM)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: United Kingdom,France,United Kingdom,France,Netherlands,United Kingdom,Slovakia,Finland,Germany,Netherlands,Belgium,Spain
Call:  (FP7-NMP-2012-LARGE-6, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 8589055.94
EU funding (EUR): 5828076.0
Participants: 17
Project status: CLOSED

Europe is a major global producer of industrial minerals. Around 180 million tonnes per year of products are extracted in the EU, with an estimated contribution of €10 billion to European GDP and offering direct employment to some 42,500 people. A secure supply of sustainable mineral products is essential to maintaining the European mining, mineral and manufacturing industries. The main objective of STOCISM is to enhance the competitiveness of the European industrial minerals industry by developing cleaner, more energy efficient extraction and processing technologies. STOICISM is an industry-led project with a specific focus on calcined industrial minerals which are presently energy intensive to produce. Most calcining uses the direct combustion of fossil fuels, contributing to up to 85% of their carbon emissions. To meet the overall aim, three key calcined industrial minerals have been identified: diatomaceous earth; perlite and kaolin. The processes implemented can also then be directly transferable to many other industrial minerals. In global terms, the EU produces one third of the world’s production of perlite, 20% of calcined kaolin and 20% of diatomite. Key markets for these minerals are beverage filtration, coatings, plastic, rubber, cosmetics, insulation and construction materials. STOICISM will research, develop and demonstrate a range of new innovative technologies along the industrial minerals value chain. This will include developments in extraction, beneficiation, drying, calcining and waste recycling. STOICISM is expected to impact significantly on the sustainability of the EU’s industrial minerals industry by decreasing the use of natural resources (both mineral deposits and energy resources) leading to the sustainable production of better and purer products with less waste and lower environmental impact.

Keywords: calcined industrial minerals,reduced waste and carbon footprint,efficient and renewable energy
Nitrogenase and Nitrous Oxide Reductase: Biomolecular Engineering of Complex Redox Enzymes (N-ABLE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Germany
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1641000.0
EU funding (EUR): 1641000.0
Participants: 1
Project status: CLOSED

Nitrogenase and nitrous oxide reductase are complex metalloenzymes that are highly sensitive to dioxygen. They catalyze economically and ecologically important chemistry, but their function is not understood in full detail. We propose to analyze the mechanisms of these enzymes and elucidate the complex biogenesis of their intricate metal cofactors, the FeMo cofactor and the CuZ site, respectively. To this end we will combine protein biochemistry under anoxic conditions with the systematic, stepwise re-assembly of the structural genes and maturation factors of nitrogenase and nitrous oxide reductase into a heterologous expression system in Escherichia coli as a host system with a facultatively anaerobic lifestyle. This approach combines the principles of protein biochemistry and synthetic biology and aims at conveying the catalytic capacities of nitrogenase and nitrous oxide reductase to a new host. Once recombinant proteins can be produced we will use directed evolution under a selection conditions of dioxygen stress to increase the oxygen-tolerance of the enzymes and extend the usability of the expression plasmids. With nitrogenase, we will then aim at transferring the ability to fix dinitrogen to eukaryotic hosts and will start with the well-established Pichia pastoris. As a long-term goal, the expression of nitrogenase in plant cells will provide the basis for a new era of green biotechnology that does not rely on chemical nitrogen fertilization.

Keywords: nitrogen fixation,greenhouse gas,metalloproteins,cofactor biosynthesis,copper proteins,carbon fixation
Development of multifunctional Thermal Barrier Coatings and modelling tools for high temperature power generation with improved efficiency (THEBARCODE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Greece,Russian Federation,Germany,Belarus,Armenia,Belgium,United Kingdom,Romania,Romania,United Kingdom
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 4098340.0
EU funding (EUR): 2921550.0
Participants: 14
Project status: CLOSED

This project is focused to advance considerably the efficiency of power generation in gas turbine processes by the development of improved thermal barrier coated parts or components of significantly improved performance as well as software products providing optimized process parameters. The proposed project addresses the following scientific and technological issues: New TBC formulations with long-term stability, more resistant under extremely severe operating conditions (e.g. creep, fatigue, thermal-mechanical fatigue, oxidation and their interactions, at high service temperatures) thus the maximum application temperature will be higher (e.g.1450-1500oC) and so performance during energy generation. Flexible and cost effective production systems based mainly on thermal spray (SPS/SPPS, APS, HVOF) but also EB-PVD in order to realize patterned functional TBCs with improved properties. Application of structural analysis and fluid simulation software, including radiation, combustion, heat transfer, fluid-structure interactions and conjugate heat transfer models for the development of detailed models for the operational performance and prediction of spallation phenomena and failure. Environmentally friendly process using chemical formulations free of hazardous and toxic solvents. The aim of this project is the development of materials, methods and models suitable to fabricate, monitor, evaluate and predict the performance and overall energy efficiency of novel thermal barrier coatings for energy generative systems. By the radical improvement of the performance (working temperature, lifetime etc) of materials “in service”, by the application of novel thermal barrier coatings, structural design and computational fluid simulations a significant improvement in energy efficiency and cost effectiveness will be achieved.

Keywords: thermal barrier coatings,ceramics materials,atmospheric plasma spraying,solution suspension plasma spraying,corrosion,modeling,spallation
Providing a new generation of methodologies and tools for cost-effective risk-based animal health surveillance systems for the benefit of livestock producers, decision makers and consumers (RISKSUR)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Belgium,France,Italy,Germany,Sweden,Norway,Spain,Netherlands
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 3968566.8
EU funding (EUR): 2998854.0
Participants: 12
Project status: CLOSED

The risk of occurrence of exotic, new (emerging), re-emerging as well as endemic diseases has increased substantially, particularly due to globalisation and intensification of animal production. While the need for effective animal health surveillance is widely recognised for the management of such threats, the currently used systems do not take optimal advantage of recent advances in epidemiological approaches, and investment is being constrained due to significant financial budget reductions in most countries. The overall aim of RISKSUR is to develop decision support tools for the design of cost-effective risk-based surveillance systems that integrate the most recent advances in epidemiological methodologies. This will be achieved by the development of evaluation frameworks for animal health surveillance system designs for three different surveillance objectives: 1) Early detection of animal disease, 2) Demonstration of freedom from animal disease, and 3) Determination of disease frequency and detection of cases of en-demic animal disease. Methods and tools for comparative epidemiological and economic evaluation of different surveillance system designs will be developed, and made available through a web-based decision support tool. The project will provide decision makers with such a validated tool tailored to their needs that allows the design of more cost-effective animal health surveillance and thereby reduces direct and indirect impact of animal disease on European citizens. Our partners represent a unique combination of internationally recognised expertise in animal dis-ease surveillance methodologies and economic evaluation as well as applied experience in delivery of surveillance programmes in a variety of socio-economic contexts from a national and global perspective. The practical implementation of the (IT) tools and the transfer of the knowledge through training and others are led by four SMEs with a strong track record in translation of research results.

Keywords: risk,surveillance,cost-effectiveness,evaluation,animal health,disease detection
‘Seeing’ with the ears, hands and bionic eyes: from theories about brain organization to visual rehabilitation (BRAINVISIONREHAB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Israel
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-09-01
End date: 2018-08-31
Duration (months): 60.0
Total project cost (EUR): 1499900.0
EU funding (EUR): 1499900.0
Participants: 1
Project status: CLOSED

My lab's work ranges from basic science, querying brain plasticity and sensory integration, to technological developments, allowing the blind to be more independent and even “see” using sounds and touch similar to bats and dolphins (a.k.a. Sensory Substitution Devices, SSDs), and back to applying these devices in research. We propose that, with proper training, any brain area or network can change the type of sensory input it uses to retrieve behaviorally task-relevant information within a matter of days. If this is true, it can have far reaching implications also for clinical rehabilitation. To achieve this, we are developing several innovative SSDs which encode the most crucial aspects of vision and increase their accessibility the blind, along with targeted, structured training protocols both in virtual environments and in real life. For instance, the “EyeMusic”, encodes colored complex images using pleasant musical scales and instruments, and the “EyeCane”, a palm-size cane, which encodes distance and depth in several directions accurately and efficiently. We provide preliminary but compelling evidence that following such training, SSDs can enable almost blind to recognize daily objects, colors, faces and facial expressions, read street signs, and aiding mobility and navigation. SSDs can also be used in conjunction with (any) invasive approach for visual rehabilitation. We are developing a novel hybrid Visual Rehabilitation Device which combines SSD and bionic eyes. In this set up, the SSDs is used in training the brain to “see” prior to surgery, in providing explanatory signal after surgery and in augmenting the capabilities of the bionic-eyes using information arriving from the same image. We will chart the dynamics of the plastic changes in the brain by performing unprecedented longitudinal Neuroimaging, Electrophysiological and Neurodisruptive approaches while individuals learn to ‘see’ using each of the visual rehabilitation approaches suggested here.

Keywords: blindness,sensory substitution,bionic eye,fmri,multisensory integration,brain plasticity
What makes our subjective perception of the world unique? (WMOSPOTWU)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 1294840.0
EU funding (EUR): 1294840.0
Participants: 1
Project status: CLOSED

We commonly assume that our perception of the world is constant and seamless. This intuition belies the dramatic differences in the perceived quality of a stimulus even within the same individual when it is shown at different spatial locations or different times. Conventional studies of perception treat such unique patterns of perceptual variability as noise and seek to eliminate them by averaging across individuals; however, studying individual heterogeneity in perceptual function can reveal insights into how the brain makes our subjective view of the world unique and personal. All perception must arise in the brain. Despite that, the neural substrates underlying this perceptual heterogeneity remain unknown. Here, I therefore propose a project to investigate cortical and perceptual heterogeneity in human volunteers using a combination of behavioural psychophysics, functional magnetic resonance imaging and transcranial magnetic stimulation. I will explore the heritability of these maps to better understand the factors underlying perceptual heterogeneity. Together, these experiments will provide convergent evidence about how the functional architecture of human sensory cortex gives rise to an individual's unique perception of the world. This will make it possible to reconstruct how an individual perceives the environment, thus giving an insight into their “mind's eye,” and has implications for patients with pathological sensory discontinuities (such as scotomas) or hallucinations, as it will enable us to reveal how they perceive their environment.

Keywords: perception,visual processing,auditory processing,fmri,brain mapping,individual differences
Inborn errors of innate immunity: systems genomics route to the core of the immune system (IMMUNOCORE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Austria
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-11-01
End date: 2018-10-31
Duration (months): 60.0
Total project cost (EUR): 1498950.0
EU funding (EUR): 1498950.0
Participants: 1
Project status: CLOSED

The ultimate relevance of a component of the innate immune system in human physiology is uncovered by the consequence of mutations in the associated gene. We have integrated systems genomics tools to mine, uncover and pathway-map primary deficiencies with high efficiency. Primary immunodeficiency disorders involving innate immunity are characterized by recurrent and life-threatening infections. ImmunoCore profits from an exquisite combination of access to a large collection of informative pedigrees, high throughput genetics/genomics such as high-resolution SNP arrays and deep sequencing as well as functional proteomics of protein complexes. This discovery engine is complemented by biochemical, immunological and imaging technologies to obtain molecular gene-to-phenotype relationships for potentially dozens of components. The initial focus of the work will be on phagocyte deficiencies such as congenital neutropenia syndromes, for which we have very recently identified two novel genetic defects. The proposed investigations are expected to contribute significantly to our understanding of the molecular processes that structure our innate immune system. These studies will not only enable a more comprehensive molecular classification system of primary immunodeficiency disorders, but also improve patient care by enabling molecular diagnosis and classification. Our investigations may serve as the basis for future development of more specific therapies targeting affected signaling cascades.

Keywords: homozygosity mapping,next generation sequencing,whole exome sequencing,whole genome sequencing,unfolded protein response,upr,er stress,apoptosis