Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Poland,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Clinical research on regenerative medicine (H2020-PHC-2015-single-stage_RTD, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 6828887.5
EU funding (EUR): 6828884.0
Participants: 14
Project status: CLOSED

CLINICAL PROBLEM AND UNMET NEED There are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection. TETRA PROJECT Our SME-led project will address the limitations of standard clinical care and competitor products under development and will: - Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients - Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases - Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication - Prepare a dossier for MAA submission BENEFITS Our product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of €517 million per year. We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases.

Keywords: atmp,tissue engineering,medical device,trachea,cell therapy,mesenchymal stem cell,scaffold,regenerative medicine,stenosis
Novel Soliton Synchronization and Interactions in Coupled Kerr Combs (NSINC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

The "N'Sinc" project aims to study novel soliton synchronization and interactions in a coupled Kerr soliton cavity network and to demonstrate dual-comb technologies enabled by these novel interactions. Temporal dissipative Kerr solitons (DKS) in micro-resonators have recently emerged as a powerful platform for both fundamental nonlinear science and ground-breaking technologies. While nearly all efforts thus far have focused on single isolated Kerr cavities, coupled Kerr cavity systems offer compelling new physics and technologies including that of passively phase-locked dual-comb spectroscopy, ranging and ultrastable RF sources. The applicant recently developed a numerical model which predicts novel soliton interactions in such a system, among them soliton synchronization and soliton “hopping” wherein a soliton abruptly hops from one cavity into an adjacent cavity. This proposal will fabricate a coupled two-cavity network and investigate its capability for the predicted effects and for other novel effects such as non-identical FSR locking. This will be pursued using both Magnesium Flouride crystalline resonators and Silicon Nitride microresonators, which are well-established technologies in the host group. This project comes at an exciting time for the Kerr soliton combs field since single Kerr cavities have become well understood and new tools have been developed which can enable the precise fabrication and control of two-cavity systems. Many of these tools have been developed in the host group. It is one of the top groups in the world and the only group in Europe capable of such a project and has been responsible for establishing the Kerr soliton combs field in Europe. Whereas many U.S. groups are pursuing similar goals, the applicant has made the first numerical predictions of such a system. This project will ensure continued European competitiveness in this field and establish the applicant as a pioneer in this exciting area in photonics sciences.

Keywords: kerr,solitons,self organization,frequency combs,micro resonator,networks
Development of an innovative sustainable strategy for selective biorecover of critical raw materials from Primary and Secondary sources (BIORECOVER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: South Africa,Spain,Spain,Spain,Spain,Sweden,Greece,France,France,Denmark,Portugal,United Kingdom
Call: New technologies for the enhanced recovery of by-products (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2024-02-29
Duration (months): 57.0
Total project cost (EUR): 6337277.5
EU funding (EUR): 6337277.5
Participants: 15
Project status: SIGNED

The objective of BIORECOVER is the R&D of a new sustainable & safe process, essentially based on biotechnology, for selective extraction of a range of Critical Raw Materials, from relevant unexploited secondary & primary sources: -Rare Earths from Bauxite Residue from Greece (MYTILINEOS) -Magnesium from Mg wastes of low grade minerals and calcination by-products- from Spain (MAGNA) -Platinum Group Metals from flotation tailings from South Africa (UWITS) & PGM slags, dusts and press cake from United Kingdom (JM) To this end, BIORECOVER will be based on the integration of 3 main stages to reach the expected recovery rates (90%), selectivity (95%) & purity (99%) (TRL from 2-3 to 5): (1) Remove the major impurities presents in raw materials sources to achieve the greater availability of the target metals for their recovery. (2) Mobilise these metals through specific and improved microorganisms to get a leachate enriched with the target CRMs. (3) Development of a specific technology for recovering metals with high selectivity & purity that meet the quality requirements for its reuse. Downstream processes will be also studied of the recovered metals for their reuse (brakes pads, oxygen sensors, powder Mg & catalysts). The different stages of the process provide it modular capacity increasing its adaptation flexibility and thus, further market penetration. LCA & LCC and a Decision Making Framework will support these aims. The awareness, trust & acceptance of the society about the importance of raw materials will be addressed by an awareness campaign and public perception studies. The project results will contribute to EU bio-mining knowledge (RMIS) and a communication with other key project will be also set up. To achieve this ambitious project, a multidisciplinary consortium covering the whole value chain (from suppliers to end users) will be involved, being represented 7 member states across EU (ES, DK, FR, LE, PT, SE & UK) and effective international cooperation with ZA

Keywords: international cooperation,resources efficiency,sustainable innovation
Topological Colloidal Double Layers (TCDL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 145287.6
EU funding (EUR): 145287.6
Participants: 1
Project status: CLOSED

Charged colloidal suspensions consist of charged micron-sized particles dispersed in a solvent with nanometer-sized ions, and they find ample applications in material science, food industry and drug development. The particle charge, together with a diffuse ion cloud that screens this particle charge, is called the electric double layer and it is pivotal in understanding the phase behaviour and interactions in these suspensions. However, no attention has been paid to the topological properties of the electric double layer. While drawing heavily on recent advances in liquid crystalline systems with topologically non-trivial orientational ordering, we propose to explore the topology of electric double layers, which could ultimately lead to enhanced stability of charged colloidal crystals. Specifically, we will focus on particles with topologically non-trivial shapes and explore the coupling between the topological invariants of the particle (such as genus) with the emergent electric double layer, and how this affects interparticle interactions and the phase behaviour. Finally, the goal of this proposal is to obtain a precise control over charged colloidal suspensions that are protected by topological, rather than only energetic binding, opening a fundamental and applied route to a new class of topological soft matter.

Keywords: topology,colloids,electric double layers,topological defects,charge regulation,colloidal crystals
Low-frequency multi-mode (SAR and penetrating) radar onboard light-weight UAV for Earth and Planetary exploration (FlyRadar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Italy,Italy,Hungary,Poland,France,France,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 1021200.0
EU funding (EUR): 1021200.0
Participants: 8
Project status: SIGNED

The proposal deals with the production of a dual-mode, low-frequency, radar installed on board of a leight-weight UAV. The radar will operate into two modes: as Synthetic Aperture Radar (SAR) and as ground penetrating radar. Both instruments provide extremely interesting images that are extensively used in Earth and Planetary observations. However, these airborne systems are bulky and can be operated only from manned aircraft both planes and helicopters. On the other hand, the few drones that can sustain such a equipment are large and heavy. In both cases, the operations are expensive and with a complicate logistic. The quantum leap of FlyRadar consists in installing this radar system onboard a small and light electric octocopters, providing low cost utilisation and easy operations. This affordable system will enlarge the user communities generating the possibility for an extensive use of FlyRadar taking advantage of the potentiality of this long-lasting innovation. The use of SAR and penetrating radar is widespread in Earth observation spanning from geological survey to archeological prospecting, from agricultural assessment to artefact detection. However, FlyRadar could be used also in planetary exploration. The NASA mission Mars2020 will test a drone and it will pave the way for the utilisation of UAVs in the in-situ exploration of Mars and Titan. The project is split in two phase. The first half of the project will be devoted in identifying the requirement, in designing instruments and in building them. The second half will be dedicated to the evaluation of FlyRadar with three experiments lasting a month each. The tests will performed in dry desert areas to avoid the negative effect of ground water and humidity on the radar signal. The test executions will be matched by month-long joint sessions for the analysis of the data, assess the scientific value and investigate the technological aspects.

Keywords: radar,mars,earth,exploration,prospecting
Northern Narratives: The Poetics of Cultural Contact between Germany and Scandinavia in the Middle Ages (NORNS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

With the conversion to Christianity, literary production in medieval Scandinavia became intertwined with the textual culture of continental Europe. This set in motion a process of interaction that continues to shape and be shaped by the evolution of European identities today. Intellectual responses to the relationship between northern Germany and Scandinavia, in particular, have been defined by rival national perspectives that turn to the medieval period to assert their legitimacy. My project questions this practice by advocating an integrative literary history of the region in the Middle Ages. By applying narrative theory to representative works of romance and historiography in the vernacular from the thirteenth to the fifteenth century, I will reveal the role played by narrative poetics in defining the cultural space around the Baltic. The project will examine the texts as a group for the first time, and thus contribute significantly to changing views of European literary history, in which intertwined regional narratives are replacing the spent force of national ones. Contemporary as it may be, I will show that the origins of this conceptual shift are to be found in a far more distant past. The project will be hosted by the Centre for Medieval Literature (CML) at the University of Southern Denmark (SDU) in Odense. My motivation is to add a new European relevance to my specialism in Medieval German Studies. This would not be possible to the same degree anywhere else. The Centre’s location, its rethinking of medieval European literature outside the national philologies, and the expertise of its members are all perfectly suited to enabling a dialogue between German and Scandinavian Studies. I will be supervised by the Centre’s leader, have direct access to its resources, and be trained in essential skills for my career in academia and engaging with audiences outside it – as at the exhibition in the Royal Library in Copenhagen in which the project will culminate.

Keywords: germany,scandinavia,middle high german,middle low german,old norse,medieval literature,history,historiography,narrative theory,middle ages
Operational characterization of quantum correlations (OPERACQC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed research aims at the operational characterization of features of correlations specific to quantum systems. This will lead to a deeper understanding of Quantum Mechanics (QM) and of the behaviour of correlated systems, and contribute to the development of revolutionary Quantum Information Processing (QIP) technologies. QIP applications include the efficient simulation of quantum systems, more precise sensors, secure communications, and, ultimately, incomparably faster computers. QIP was born from the recognition that information can be processed according to the laws of QM. At the core of the advantage of QIP over classical information processing lie quantum correlations, in which Dr Piani is an expert. Dr Piani will characterize several forms of quantum correlations in a systematic and unified way. The results will directly link to operational scenarios and applications, for example in metrology and communication. Where relevant, the characterization will take into account physical and practical constraints and limitations deriving from, e.g., the finite energy involved in physical processes and the necessarily incomplete information accessible to experimentalists. The host organization, the University of Strathclyde, will provide Dr Piani with the opportunity to establish a new research line in QIP at the Department of Physics, a stepping-stone towards a senior academic position. Thanks to his conceptual, mathematical and information-theoretic approach, Dr Piani will develop a research programme that will integrate and complement the research activities of the Computational Nonlinear and Quantum Optics (CNQO) group. As a member of the CNQO group, and especially through the collaboration with the supervisor Prof A. J. Daley, which is directed to the study and verification of quantum correlations in Atomic, Molecular, and Optical (AMO) physical systems, Dr Piani will develop and apply his expertise to AMO physics at the highest international level.

Keywords: entanglement,quantum correlations,quantum nonlocality,quantum steering,channel discrimination,cold atoms,orbital angular momentum
Being ‘Mad’ in Byzantium. Toward a History of Mental Disorders in Early and Middle Greek Middle Ages (MadByz)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2024-11-15
Duration (months): 36.0
Total project cost (EUR): 328968.0
EU funding (EUR): 328968.0
Participants: 1
Project status: SIGNED

This proposal explores Byzantine medical views on mental disorders and their impact on narratives, perceptions and experiences of mental illness in the Greek Middle Ages. The Byzantine world is most notably absent from cultural and historical surveys on madness and medicine in pre-modern societies. And yet Byzantium tells us a story worth hearing. Byzantine responses to cognitive and behavioral disorders capture the biological, psychological and social complexity of mental illness resonating with the epistemic pluralism advocated by global mental health studies. By investigating how medical concepts trickle down and affect folk concepts of madness, MadByz challenges the master narrative according to which the Greek Middle Ages understood mental illness only in supernatural terms. By contrast, this proposal argues that Byzantine naturalistic understandings of mental illness are part of a cluster of different discourses on insanity, testifying to the coexistence of varied views on mental disorders. MadByz builds on the experienced researcher’s previous research in the field of history of medicine and on “madness” in ancient times, expanding his expertise and providing new training opportunities in Byzantine Greek, Narratology and Disability Studies. By offering a systematic study of a wide array of sources, MadByz is an essential stepping-stone toward a better understanding of the history and the circulation of key scientific ideas in the Middle Ages. By engaging with the entanglements and conflicts between concepts of mental disorders, MadByz also looks at the place occupied by the mentally ill within their socio-familiar and broader institutional framework. In so doing, MadByz impacts on the way we look at the past and at the present of mental illness, questioning our views and assumptions on key issues of stigmatization and institutionalization, as well as of segregation and inclusion, which are at the heart of mental health policies promoted by the OECD and the EU

Keywords: byzantine studies,history of byzantine medicine,history of madness and mental health,disability studies,religious studies,patristics
Precision mass spectrometry to leverage applications in life and environmental sciences (Precision4Life)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The unbeatable performance leaders in molecular analysis of biological and environmental samples are the Fourier transform mass spectrometers (FTMS): Orbitrap FTMS and ion cyclotron resonance (FT-ICR MS). However, even FTMS approaches suffer from performance limitations when facing the molecular complexity of samples in modern applications. The primary reasons for these limitations are the space charge effects – strong Coulombic interactions of many ions oscillating in the trapping devices. Applications suffering from space charge affects include those with (i) significant fluctuation of incoming ion currents; (ii) close spacing of molecular mass/charge ratios to be resolved; and (iii) high spectral dynamic range of ion intensities. To address these performance challenges and as a result of the completed ERC Starting Grant, we propose to increase precision of mass measurements in FT-ICR MS by using the direct cyclotron frequency measurements instead of the space charge-sensitive reduced cyclotron frequency measurements employed currently. We have confirmed the principal feasibility of FT-ICR MS at the cyclotron frequency on both types of commercial FT-ICR MS instruments on the lab level. The aim of our PoC grant application is to realize the benefits of FT-ICR MS at the cyclotron frequency by developing and seamlessly integrating the laboratory-level innovation into commercial instruments at an industry-grade level to leverage life and environmental sciences applications. The action plan includes: (i) enabling integration of prototype ICR mass analyzers into commercial FT-ICR MS instruments via feasibility studies and pilot projects; (ii) analyzing competitive advantages of the project’s outcomes over existing products and workflows, with a focus on frequency (mass) precision increase; (iii) clarifying IPR position, strategy; and (iv) performing market analysis.

Keywords: mass spectrometry,fourier transform mass spectrometry,ion cyclotron resonance,mass analyzer,mass accuracy,resolution,imaging mass spectrometry,proteomics,petroleomics