Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Promoting Integrity as an Integral Dimension of Excellence in Research (PRINTEGER)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Italy,Norway,Belgium,Netherlands,Netherlands,United Kingdom
Call: Ethics in Research: Promoting Integrity (H2020-GARRI-2014-1, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 1987780.0
EU funding (EUR): 1987779.75
Participants: 8
Project status: CLOSED

Research integrity is a growing concern among scientists, research organisations, policy makers, and the public, expressed in a proliferation of ethical codes, guidelines, and procedures. While this proliferation calls for harmonisation and coordination, there is little factual knowledge about the actual processes leading to misconduct or the effectiveness of current integrity policies. PRINTEGER analyses the incidence and individual, social, and organisational causes and dynamics of misconduct. It also analyses how institutions respond to allegations, specifically in interaction with neighbouring law, the media, complex research organisations, and systemic changes in research. From the perspective of the research work floor, including the daily work of journal editors or research managers, PRINTEGER will analyse how current instruments of integrity policy operate in practice. How do guidelines most contribute to integrity? What other instruments and procedures will promote integrity? PRINTEGER will provide concrete tools and advice to promote research integrity in Europe through four specific target groups: • advice on an optimal policy mix and opportunities for harmonisation to research policy makers; • best practice approaches to foster integrity for research leaders and managers; • advice on the use of IT tools and organisational measures for research support organisations; • practice-informed educational tools for ethical training and reflection of early career scientists. PRINTEGER uses a unique approach that looks at procedures and guidelines, but also analyses how they operate in the context of daily research practice. For this purpose, PRINTEGER gathers not only ethicists, but also very pertinent expertise that has barely informed integrity policy so far: legal studies, scientometrics, and social sciences, such as criminology and media studies; all flanked by intensive stakeholder consultation and dissemination activities to maximise impact.

Keywords: research integrity,misconduct,it tools,numbers of allegations,incidence of misconduct,misconduct cases,codes of conduct,guidelines,harmonisation,integrity in practice,education
Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia (HyHeat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.

Keywords: gold nanoparticles,hydra vulgaris,nanoparticle mediated hyperthermia,gene expression profile,mice
Evaluation of Plant Signaling Networks in Natural Environments (SIGNAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Argentina,Spain,Switzerland,Sweden,Chile
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 414000.0
EU funding (EUR): 414000.0
Participants: 7
Project status: CLOSED

A critical characteristic of plant development is the strong influence of environmental factors as modulators of developmental programs. Among those factors, light, temperature and nutrient availability dominate developmental decisions, and can dramatically alter plant shape, biomass production and fruit set –all of them important agronomic traits. Research during the past thirty years has defined different molecular mechanisms by which plants perceive environmental signals and transduce this information into changes in gene expression and other cellular processes, ultimately triggering the appropriate adaptive responses. However, current knowledge has at least two important weaknesses: (i) it is based on mostly on the analysis under conditions where only one environmental factor is changed, while natural environments are more complex; and (ii) most studies have been performed at the seedling stage, while the influence of the environment becomes even more relevant at later stages from an agronomical perspective. This project addresses the evaluation plant performance under complex combinations of light, temperature and nutrient conditions, using the previous knowledge generated by the participants and other laboratories, and analyzing three key stages of a plant’s life: seedling establishment, vegetative growth (biomass production), and reproductive development (flowering and fruit set). The international consortium is formed by researchers from five countries, with strong complementary technical and scientific expertises spanning light and temperature signaling, hormone action, natural genetic variation, large-scale phenotyping of adult plants, nutrient assimilation and systems biology integration.

Keywords: plants,hormones,light,temperature,nutrient availability,adaptation
Image learning to create a new online marketing tool (ShopStar)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Europe’s media industry lacks an effective business model for their online content, particularly in the context of falling revenues from traditional online advertising – they need new ways to effectively monetise their content. Our aim is to allow media to generate revenue from their online images. We apply innovative image-analysis technology to detect clothes in online images, and match them with clothes in retailers’ online product catalogues. This creates a lucrative collaboration between online media and retailers – for every customer redirected to a retailers’ website via an online image, media publications receive a commission fee. An initial version of this automated technology (running in under 300 milliseconds) has already been developed. We can recognise photos of clothes in isolation (an image of an item of clothing on a plain background) and match them to the clothes sold by our 8000 partner retailers (Amazon, H&M…). We then give readers the opportunity to click to find a link to buy the same or similar item. This solution has already been commercialised to several leading magazines (including Closer, Grazia & Be), who have seen online advertising revenues increase by up to 6 times. However, photos of clothes in isolation represent only a small proportion of online images. Our ambition is therefore to adapt our technology to detect clothes in photos of people – representing a much larger proportion of online images. Online readers will be able to click to “Get the Look” of a celebrity or public figure in an online photo, and will be shown links to retailers selling similar items. The aim of our feasibility study is to refine the technological specifications and validate the commercial proof of concept with a base of current and potential clients. With ShopStar, we are creating a non-invasive advertising solution that can be deployed to international media groups worldwide, positioning Shopedia as category leader for this disruptive new approach

Keywords: online media,advertising,e commerce,intelligent image analysis,vision technology,machine learning
Energetics of Biological Systems (EnBioSys)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1935240.0
EU funding (EUR): 1935240.0
Participants: 1
Project status: SIGNED

All living systems function out of thermodynamic equilibrium and require a continuous supply of energy. To understand how cells and organisms function, we need to determine how metabolic energy is partitioned among the complex array of cellular processes that are necessary for life at any scale, from isolated biochemical networks to quiescent and highly proliferative cells to organismal growth and development. To investigate the energetics of living systems, I established calorimetry to measure the energy exchanged in the form of heat between biological systems and their environment. By combining these measurements with specific perturbations, I have shown that the energetic costs associated with a given biological process can be calculated, and thus, provides a means towards understanding the energetics of biological systems. This proposal aims to understand the energetic costs of accurate cell signaling, and of homeostasis, proliferation, and growth of cells and organisms. It will further investigate how these biological systems are governed by energetic trade-offs. First, the trade-off between energy dissipation and accuracy of biochemical signaling pathways. Second, the trade-off between power and yield during cell growth and organismal development. Specifically, I will: 1) Develop approaches to quantify the overall energetics of biological systems 2) Elucidate the role of energy dissipation on the accuracy and reproducibility of cell cycle signaling 3) Determine how energetics drive embryonic development and cell growth This work will overcome the current lack of non-invasive techniques to quantitatively measure metabolic rates, especially rates of energy conversion and dissipation in biological systems. The results will yield quantitative thermodynamic data needed to determine the energetics of biological systems and will be essential for kinetic growth studies of normal and diseased systems.

Keywords: calorimetry,thermodynamics,energetic trade off,homeostasis,growth,embryonic development,physics of biological systems
Removal and Mitigation of Pollution from the Use of Pesticides: Prevention, Recycling and Resource Management (RECYCLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,Australia,Israel,Germany,Spain,Italy,China,Belgium,United States,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 1347800.0
EU funding (EUR): 1347800.0
Participants: 13
Project status: SIGNED

Flux of pesticides from agricultural areas to surface waters is wasting a resource which is becoming scarce and is in conflict with the principles of a circular economy. Enhanced loading of surface water with pesticides is the main cause for eutrophication and is one of the key challenges in meeting the objectives of the EU Water Framework Directive. RECYCLE targets both problems and develops new methods and approaches to trap pesticide components in drained agricultural areas and in the sediments of eutrophic streams. Main vision of RECYCLE is to develop a new technology to trap the used pesticide components and reuse them for agricultural purposes. The vision of RECYCLE is set forward through a coordinated research program grounded on strong collaboration and implemented through secondments between world-leading teams encompassing academic and private sectors, both within and outside the EU. These activities are strongly interlaced with periodic workshops and summer schools to share the latest findings and further propel the acquired knowledge within a market-oriented view. All secondments and training activities are structured within a framework designed to maximize advancement of knowledge and career development as well promoting the enhancement of the participating experienced and early career researchers and professionals. Integration of nonacademic partners from various stakeholder groups into the RECYCLE consortium paves the way for direct implementation of the acquired knowledge.
Privacy on the move: two-way Processes, Data and Legacy of Danish metropolitan and colonial Architecture and Urbanism (INDIABRIDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 310968.0
EU funding (EUR): 310968.0
Participants: 1
Project status: SIGNED

INDIABRIDGE aims to produce an understanding of the historical notions of privacy in architecture and urbanism since the 17th century were a bilateral mechanism between West and East. This will be achieved by analysing and recording border-crossing patterns and relationships in the built environment between Denmark and India. I will claim that Danish colonial architecture in India and the imprint of Indian architecture in metropolitan Denmark, represented a larger history of influence on how notions of privacy shape relations between individuals and society across diverse historical contexts. By combining architectural and urbanism with history, anthropology and area studies’, my intention is to map and analyse border-crossing patterns and relationships of privacy between Denmark and the India. Accordingly, I will conduct the research through systematic, site-based, interdisciplinary spatial analysis of the Danish case studies of Tranquebar and Serampore, two former Danish colonial cities in India. It will locate Tranquebar and Serampore within the shifting locations of European architectural narratives in India and will propose relating other European colonial case studies, which enables comparative analysis between Northern and Southern Europe. I will approach the built environment in Denmark and in India as a material and spatial reality that has persisted through the notion of privacy. The benefits are two-fold. First, I will establish research on privacy in Danish colonial architecture and urbanism, with the ambition of turning it into a forum for comparative and interdisciplinary enquiry in the field and ultimately in the host institution. Second, I will re-launch academic career in a specialized collaborative research infrastructure with focus on the built environment itself. It will be a key to document and study the coming into being of Danish architecture and urbanism in Asia as a relevant Northern European case study for historical notions of privacy.

Keywords: privacy,danish architectural history,danish urban history,area studies,european history
Geomorphic and Sedimentary responses to Climate Periodicity (GyroSCoPe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1963229.0
EU funding (EUR): 1963229.0
Participants: 1
Project status: SIGNED

Under the threat of ongoing global warming, predictions concerning how much temperatures will rise and precipitation will change are undergoing continual improvement, but the spatial distribution of predicted changes and their impacts on Earth-surface processes, notably erosion and sedimentation, are subject to great uncertainty. Such processes have immediate consequences for people living along alluvial or “transport-limited” rivers, which constitute the majority of rivers on Earth, yet their evolution in response to external forcing conditions is not well understood. In the GyroSCoPe project, I will address these knowledge gaps through an innovative approach that focuses on how periodic changes in climate affect Earth-surface processes. Specifically, because the dominant forcing frequencies have changed through time (notably at the Mid-Pleistocene Transition, MPT), and the frequency of each forcing period likely dictates how far downstream in alluvial channels impacts are felt, it should be possible to decipher the impacts of individual periodic forcings in the geologic record. To do this, I will apply novel tools to decipher erosion histories in mountainous regions, specifically at the MPT, and I will investigate alluvial fans and terraces in the context of a new numerical model developed by my group. These data will allow me to interpret the impact of a change in the dominant forcing period on hillslope erosion rates, track how this sediment propagates across landscapes through alluvial rivers, and thus provide a wealth of data that can be used to calibrate landscape-evolution and alluvial-channel models. This improved understanding of the fundamental impacts of the magnitude and frequency of periodic forcing on erosion rates and sediment transport through rivers will in turn enable (1) the use of terraces and fans as paleoclimate proxies, which can be used to test climate models and (2) predicting Earth-surface responses to ongoing and future climate changes.

Keywords: earth surface processes,climate forcing,thermochronology,cosmogenic nuclides,alluvial channels,numerical modelling
Design of an agricultural greenhouse for intensive growing of microalgae in fresh / sea water with a syngas production plant and organic farming of chickens and pigs outdoors. (ECO-LOGIC GREEN FARM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2015-08-01
End date: 2017-01-31
Duration (months): 18.0
Total project cost (EUR): 3554500.0
EU funding (EUR): 2488150.0
Participants: 1
Project status: CLOSED

According to many international studies, world population growth and climate change will end in a reduction of food, energy and pharmaceutical resources. One possible solution is an increase in the production of microalgae. The business opportunity consists in the construction of a production plant integrating algae cultivation in photobioreactors with a syngas CHP as a source of carbon, required for the photosynthetic process of microalgae. Market application deriving from algae include: biomass for combustion and organic matrix for anaerobic digestion plants; food supplements for human/animal use; pharmaceutical/cosmetics products; fertilizers; complete pilot line for cultivation. Other applications include licensing of concept, technology and brand and experimental photobioreactors for bio-lighting algae research. It is a growing market with a world potential estimated at +30% each year and a global size of 150M€ in 2016. Key reasons explaining its novelty are: reduced need of land; use in low-quality agricultural land; no emissions of greenhouse gases/pollutants; absence of aggressive waters; significant amount of carbon dioxide captured and stored; pure product with high Ω3 content. Potential customers include: food supplement producers and retailers; livestock and poultry producers; pharmaceutical and cosmetics industry; agricultural product retailers and farmers; bio-fuel refineries; agricultural and processing companies interested in market replication or in becoming licensees; research institutions; general public, families and young people. The structure of the work plan starts with the management (WP1), includes one WP devoted to a pilot line for microalgae production, including PBRs for research on bio-lighting algae (WP2) and continues with a WP dealing with pilot production, performance verification and market replication (WP3). WP4 will take care of dissemination, exploitation and marketing. Communication will be covered by WP5.

Keywords: greenhouse,intensive growing,microalgae,water,syngas,organic farming