Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Glue of Society: A Social Ontology of Social Cohesion (GLUE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499943.0
EU funding (EUR): 1499943.0
Participants: 1
Project status: SIGNED

Social cohesion is a key concept in how we think about the social world. And yet, we have a very poor conceptual understanding of what social cohesion is, how it relates to other social phenomena, and which role it plays in maintaining social order and facilitating cooperation. To date, this challenge has not been taken up by social ontology. Contemporary social ontology primarily focuses on understanding the nature of collective cooperation in which people coalesce around a joint purpose in such a way that we can attribute attitudes and actions to them as a collective rather than as an aggregation of individuals. But social cohesion is not only a function of collective cooperation but also the extent to which a social system enables mutually sustaining cooperation among agents with separate goals. Call this converging cooperation. It seems then that social cohesion is a key concept in how we think about the social world that lies beyond the scope of social ontology in its current form. Responding to this impasse, the aim of the GLUE project is to secure philosophical clarification of the concept of social cohesion and to account for its role in constituting and maintaining the social world. The primary research questions are: 1) What is social cohesion, and which distinct social phenomenon might it refer to? 2) What are the semantically explanatory relations between (a) social cohesion and (b) the concepts often used in social ontology and the social sciences to account for collective cooperation? 3) How can a clearer account of social cohesion be used to foster social stability? Combining descriptive, explanatory, and critical approaches to social ontology, GLUE (a) enriches our typology of social dynamics, (b) expands the scope of social ontology beyond collective cooperation, (c) introduces concepts that can help identify and mitigate forms of social destabilisation, and (d) develops a new and integrative research method for social ontology.

Keywords: social cohesion social ontology phenomenology
Epistemology in Science, Technology, Engineering, Arts, and Maths. (EPISTEAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Latvia,Cyprus,Romania,Spain,Germany,France,United States,Netherlands,India
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 851657.14
EU funding (EUR): 841800.0
Participants: 14
Project status: SIGNED

The main aim of Epistemology in Art, Science, Technology (EpisTeaM) is to develop a collaborative consortium and intersectoral network to test the hypothesis that diversification of epistemological positions could be the key to responsible Epistemology in Technological Education and Innovation. The fundamental problem being addressed is the impact of digital technologies on the construction of knowledge and truth, an ‘epistemic crisis’ inside and outside academia. Epistemology is explored as cultural Episteme, disciplinary Epistemology and whole experimental approach. Epistemological diversification through transdisciplinary research is essential and will be investigated through the intersections of Art, Science and Technology by an expansion of the concepts Techne, technics and Technology in the context of disciplinary activity. In the contemporary context of globalised computational conditions, the question of the impact of digital technologies on knowledge is often understood as misinformation and post-truth, however, there is also an inbuilt epistemological conditioning taking place through the digital technologies themselves. For this purpose, a large transdisciplinary research mobility is necessary in order to understand the localised contextualisation of digital technologies within the disciplines, cultures and research laboratories. The traditional epistemological frameworks and paradigms are currently challenged by globalised computational models, where reason itself has been reduced to calculation and probability. EpisTeaM will explore and challenge this dominant epistemological claim. Just as a biodiversity is necessary for the future sustainability of the planet, so too is a Technodiversity within the Technosphere of globalised computation. The partners are from the European University of Technology (ECT Lab+), USA, India and non-academic partners in Europe (SME and Public Bodies).

Keywords: alternative epistemologies,trans disciplinarity,new media,neuroscience,fundamental physics
Multilingualism and Sustainability in Education in Amazon Trapezium (MultiSEAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Colombia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 258135.36
EU funding (EUR): 258135.36
Participants: 3
Project status: SIGNED

MultiSEAT is a timely, participatory research project aiming to expand the frontiers of multilingualism toward socio-ecological and environmental research to contribute to education for nature protection and sustainability. Focusing on an indigenous multi-ethnic and multilingual school in Leticia (Amazon Trapezium), the project has three research objectives: 1. Design and implement multilingually a community-based participatory methodology allowing the collection of socio-ecological and ethnographic interactional data about food supply systems (FSS), deforestation (DEF), and ecotourism (ECOT); 02. Provide insights into the ideological stances (perceptions, attitudes, beliefs, and representations) that the school community and their families have on these socio-ecological issues; and 03. Design a pilot of three research-based Multilingual, Inclusive Teaching Sequences (MITS) to tackle FSS, DEF, and ECOT within the indigenous school. To achieve these aims, MultiSEAT will empower young people from the school through participatory research, engaging them in collecting quantitative and qualitative socio-ecological and ethnographic data. Analysing indigenous perceptions of environmental issues will provide insights into the complex relations between people, language, and nature. Also, by considering language as a plurilingual praxis in the design of the MITS, we will focus on what people do and can achieve with their multilingual resources as eco-linguistic capital. At project end, the scientific community will have an empirically based, comprehensive understanding of how the triangle ‘people-language-nature’ works. We will also provide expertise and guidance to non-indigenous local and global communities, policymakers, SMEs interested in bioeconomy, teachers, private/public funders, and stakeholders engaged in sustainability in Amazonia in the implementation of interdisciplinary methods to operate changes through multilingualism, education and environmental research.

Keywords: multilingualism,social and environmental justice,youth empowerment,education for sustainability
QACR - Kidney Check: The First Quantitative At-Home Test for Early Detection and Monitoring of Chronic Kidney Disease, Anytime, Anywhere (QACR - Kidney Check)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Chronic kidney disease (CKD) affects over 75 million people in Europe, yet remains vastly underdiagnosed and poorly monitored due to low screening adherence and fragmented follow-up. Early detection and consistent monitoring are critical, as timely intervention can slow or even prevent progression to kidney failure. Current testing methods, laboratory-based or semi-quantitative dipsticks, create logistical barriers, delay results, and limit the ability to track disease progression or treatment effectiveness. QACR – Kidney Check introduces a breakthrough in preventive and longitudinal diagnostics: the first fully quantitative, smartphone-based urine albumin-to-creatinine ratio (uACR) test for home use. The system integrates microfluidics, proprietary biochemistry, and AI-driven computer vision to deliver lab-grade accuracy within minutes, anywhere, by anyone -- no instruments or professional supervision required. Beyond screening, QACR enables continuous, at-home monitoring of kidney health, providing immediate and actionable data to patients, physicians, and care teams. This supports proactive disease management, medication optimization, and remote follow-up programs, all of which are central to value-based and preventive care models. By embedding into existing healthcare workflows, the QACR platform bridges the gap between diagnosis and ongoing management, empowering patients while reducing the burden on health systems. The project will finalize product design for large-scale manufacturing, complete analytical and usability validation, and achieve CE marking and FDA clearance. Ultimately, QACR lays the foundation for a new generation of quantitative, smartphone-based diagnostics that bring lab-grade testing to every home, transforming access, adherence, and outcomes in chronic disease care.

Keywords: chronic kidney disease ckd,at home diagnostics,quantitative urine testing,ai and computer vision,microfluidics,preventive healthcare,digital health innovation
Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients (Histotype Px)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator Challenge: Novel biomarker-based assays to guide personalised cancer treatment (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 5326967.5
EU funding (EUR): 2499999.99
Participants: 1
Project status: SIGNED

There is consensus in the oncology community that there is a large need for personalized cancer treatment decisions as patients suffer from large-scale overtreatment. Up to 90% of patients receiving adjuvant chemotherapy have no effect, many suffer severe side effects. DoMore Diagnostics (DoMore Dx) delivers pioneering diagnostics software that enables personalized cancer treatment in a simple and cost-efficient way. We provide deep learning algorithms applied to cancer tissue whole slide images (WSI) in the adjuvant chemotherapy setting. With end-to-end deep learning we have taken a completely new approach to this challenge. Our test can be run in local labs with digital pathology equipment and does not consume any tissue. DoMore Dx is personalized medicine made simple. In CRC, our test can stratify patients into low, intermediate, or high risk with a hazard ratio >10. This information can be used to take up to 250,000 patients out of chemotherapy and save 4 billion EUR globally every year.

Keywords: colorectal cancer medical imagining histology machine learning prognosis prediction therapy guidance
SYLVER: Advancing Point-of-Care Neuromonitoring with a Scalable 3D Clinical Transcranial Ultrasound Imaging Device and Numerical Biomarkers (SYLVER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Resolve Stroke addresses the global burden of acute neurological disorders, emphasizing challenges in stroke management & neurocritical care. Crucial for both acute & subacute patient care, brain imaging influences diagnosis, treatment decisions, & post-treatment monitoring. Limited access to high-resolution imaging tools like MRI & CT causes critical treatment delays. We introduce SYLVER, a 3D clinical ultrasound imaging platform assessing brain hemodynamics & perfusion at patient’s bedside. The platform is designed to incorporate new biomarkers in the future, broadening the potential scope of brain diagnostics. Using ultrasound & advanced post-processing algorithms, SYLVER achieves high-level imaging, bridging the gap between traditional ultrasound & MRI/CT. Our technology promises superior precision and speed, with applications in neuroimaging & tumor vascularity assessments. With EIC support, we aim to reinforce SYLVER's clinical benefits and target a first launch in Europe.

Keywords: super resolution ultrasound,neurocritical care,stroke management,point of care imaging,bedside brain imaging
STEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES (NSC-PLAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2499783.75
EU funding (EUR): 2499783.75
Participants: 1
Project status: SIGNED

Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge. To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironment. In the subependymal zone of the adult rodent brain, self-renewing neural SCs (NSCs) generate new neurons for pre-existing olfactory circuits. It is clear that NSCs must be endowed with plasticity properties, but the analysis of these potential traits needs a precise definition and a combination of comprehensive approaches to unravel their molecular regulation. Building from our new technologies and some preliminary data, in this proposal we will try to advance in the molecular basis and extent of the cell plasticity repertoire of adult subependymal NSCs by concentrating in three of its potential forms: Epithelial plasticity, or the ability to dynamically and reversibly undergo epithelial-to-mesenchymal transitions, a form of cell adaptation that has never been conceptually proposed or evaluated in adult NSCs. Cycling plasticity, or the ability to move in and out of the cell cycle and remain quiescent for long periods of time. This plasticity clearly exists, but its molecular regulation remains largely elusive. Immune plasticity, or the capacity to evade adaptive immunity. Our view about immunity in the brain has dramatically changed in the last few years, raising interest in its potential interaction with NSCs. Understanding cell plasticity traits in NSCs may contribute to understand not only NSC and/or SC behavior, but also glioma biology and to identify pathways to intervene in brain tumor treatment.

Keywords: adult stem cells,cell plasticity,epithelial mesenchymal transitions,cell cycling,quiescence,adaptive immunity
The role of tanycytic cilia in hypothalamic functions. (TanyCilia)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Obesity and metabolic diseases are a top priority challenge for health systems. Monitoring changes in the body’s energy levels is a task of the hypothalamus (HpT) which integrates the actions of peripheral hormones and nutrients with neural information. However, this regulation is complex, and the causes and biological mechanisms leading to metabolic disorders remain to be explored. Among the cells involved, tanycytes play a key role. They are glial cells that line the third ventricle and mediate information about changes in the circulation to various HpT nuclei. They regulate important neuroendocrine functions such as food intake and energy balance. Although tanycytes are known to integrate external and internal signals, the specific cellular organelles through which they sense these cues remain unknown. Primary cilia (PC) are one such compartment crucial for perceiving peripheral signals, and they are indeed present in tanycytes. We have coined the name tanycilia for them. However, the function of tanycilia is still unclear. Here, we hypothesize that cilia may act as antennae for tanycytes, sensing nutrients or hormones, enabling adaptive cellular responses, and transmitting metabolic information to neurons. This project aims to I) characterize tanycilia morphology for the first time; II) identify their functions, primarily in the regulation of metabolism; and III) examine them in pathological contexts like obesity and anorexia. To achieve these goals, we will employ immunohistochemical techniques to characterize tanycilia in wild-type mice. To investigate their function, we will genetically manipulate tanycilia using inducible mouse models in combination with tanycyte-specific adeno-associated viruses (rAAV). The discovery of tanycilia's roles in integrating peripheral signals to regulate neuroendocrine functions holds promise for understanding and treating metabolic disorders.

Keywords: tanycytes,primary cilia,signalling pathways,metabolism,reproduction,hypothalamus,calcium activity,obesity,anorexia
HOme WAves. Home-making and life trajectories in flood-risk areas of Central Mozambique (HOWA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

HOWA is an interdisciplinary research project belonging to critical African Studies, examining how home-making is reshaped under flood risk exposure in Central Mozambique. The project is premised on the conception of homes as speaking subjects telling us about the entanglements between individual paths, kinship, the environment and the socio-political context. In Mozambique’s low-income contexts, as elsewhere in Africa, people speak through their homes. House-building is a self-authored material and symbolic (non-verbal) language and, therefore, a fertile analytical field. In conditions of material, social and symbolic disruption, as is the case with repeated experiences of flooding, home-making and house building together reveal the complex life paths enacted within (and without) them. Floods are a major and increasingly frequent cause of disaster in eastern Sub-Saharan Africa. 30% of Mozambicans live in permanent flood vulnerability. HOWA investigates how home-making is reshaped in terms of (i) materiality, (ii) sociality and (iii) temporality under enduring flood exposure and displacement. It examines which life trajectories are enacted by, entangled with, and redirect through, the act of home-making before and after flood exposure. A relational and interdisciplinary approach is applied to the multiple dimensions of displacement and resettling. Different types of settings (urban neighbourhoods, resettlement sites, transitional areas) are studied with clusters of methods guided by an ethnographic and house biographical approach. The method itself becomes a form of activism enacted through the research process. By innovatively combining analysis of home-making, displacement, and life trajectories, HOWA in-depth, micro-scale studies hold both social and policy relevance in a time in which disaster-related displacement of vulnerable people is becoming more frequent, transforming interventions through revealing the links between risk and spatial and social belonging.

Keywords: african studies home making mozambique flood risk interdisciplinary displacement studies life trajectories