Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accelerate Sustainable Enabling of Oxygen Evolution Reaction Catalyst for Water Electrolysis (ABLE OER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Large scale synthesis of efficient, durable, and environmentally friendly electrocatalysts is key for commercialization of proton exchange membrane water electrolysis (PEMWE), which is a vital route for renewable H2 production. State-of-the-art PEMWE is limited by the high price of the electrocatalysts which are composed of Ir, Pt and Ru (40% of fabrication costs of PEMWE). Against this background, the project ABLE OER aims to develop, characterize, and electrochemically evaluate low-cost, and up-scale supported electrocatalysts from commercial and recycled precursors using microwave continuous flow synthesis (MWCFS). The specific objectives of ABLE OER are to provide proof-of-concepts on i) synthesis of active and robust supported-OER catalyst, which reduces Ir loading by 80% at equivalent activity; ii) incorporation of abundant nano ceramics (as support material) and secondary PGMs for OER catalyst to reduce material cost by 70%; iii) an up-scalable continuous OER catalyst synthesis process, which lowers the production cost by 50%. The novel catalyst structure and the associated synthesis process will accelerate technological advancement and societal adoption of the PEMWE technology. My experience in inorganic materials and electrochemistry combined with the expertise of the host group in electrocatalysis for water splitting and recycling will synergistically contribute to achieving the ambitious aims of this project, which will be implemented at the University of Southern Denmark. I will learn new techniques in up-scale production of catalysts, mature my skills as an independent researcher, and increase my network to nurture international collaborations. The results of this project have the potential to greatly reduce the cost of H2 generated from renewable sources and thus transform the European and global energy sector.

Keywords: water splitting,electrocatalysis,microwaves synthesis,recycling
Shared anchors for floating wind turbines (ShareWind)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Norway,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 3
Project status: CLOSED

On the framework of the energy transition in Europe, new technologies are under research, development and implementation. One of the targets of the European Commission is by 2030 to achieve a 32% of energy capacity based on renewable sources . Offshore wind energy is one of the renewable energy sources contemplated in the European Strategic Energy Technology Plan (SET Plan) as part of the actions for research and innovation. New potential areas with more intense and stable wind conditions and minimized visual impact on the coastline have been identified (deep waters of >60 m depth). This motivates the idea of implementing floating wind turbines as an alternative to reach deep water locations with a great potential as a step further in the offshore wind industry. One of the main challenges for this technology is the cost associated with the construction of the platforms for the wind turbines and the mooring systems to anchor the turbines in deep water. One of the solutions to optimize offshore floating wind farms costs is sharing the anchors connected to the mooring systems that secure the wind turbines when subjected to the ocean environmental laods. The research proposed here "Shared anchors for floating wind turbines- ShareWind", aims to provide design guidelines and evaluate the loading capacity of shared anchors installed in clayey seabed profiles as most of the research on this topic has been adressed in sands. As part of ShareWind, the applicant will (i) develop physical models of shared anchors to be tested at theUniv.Eiffel (France) geotechnical centrifuge, (ii) perform numerical simulations and parametric studies to provide design guidelines and failure envelopes of anchors subjected to multidirectional cyclic loading. The results of ShareWind will be integrated in design frameworks to predict the loading capacity and displacements of shared anchors with impacts in their long-term performance and in the optimization of costs of floating wind farms.

Keywords: geotechnical,offshore engineering,soil mechanics,physical modelling,wind turbines
Differential Diagnosis of Autoimmune Hepatitis by cfChIP-seq Liquid Biopsy (AIHLiquidBiopsy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-08-01
End date: 2026-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The identification of the causative agent and mechanism of liver disorders is essential for effective treatment. The diagnostic challenge is differentiating autoimmune hepatitis, drug induced liver damage, and other non-viral causes of liver disease. Current diagnostic guidelines require in many cases liver biopsy followed by monitoring response to treatment before conclusive diagnosis. Our objective is to replace liver biopsy in the parenchymal liver disease settings with a minimally invasive liquid biopsy from a blood sample. We have developed cfChIP-seq, a liquid biopsy that enables detection of gene activity in the cells contributing to cell-free DNA. Cell-free DNA is mostly chromatin fragments — DNA-protein complexes. These carry post-translational epigenetic marks that are closely connected to gene regulation and activity in the cell of origin. By capturing fragments marked with active transcription and sequencing their DNA, we map genome-wide activity of genes in the cells contributing to circulating cell-free DNA. Liver damage results in increased contribution of liver cells to circulating cell-free DNA. Moreover, our preliminary results show that we can detect differences in the cfChIP-seq signal from different liver pathologies and that these differences involve genes associated with the relevant liver damage mechanisms. We plan to develop methods for differential diagnosis of autoimmune liver diseases such as autoimmune hepatitis and other parenchymal liver diseases. This will be supplemented by a multi-center cohort of patients to train and validate these tools. Together these will establish a pre-clinical evaluation of the capabilities of the assay in differential diagnosis and enable development of a product that would change the way we diagnose these diseases. This product will improve the quality of diagnosis, reduce the number of liver biopsies, risk to patients and costs, and provide more detailed follow-up during treatment.
Magneto-Optically Reconfigurable Photonic Neuromorphic Networks (MORPHON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1676425.0
EU funding (EUR): 1676425.0
Participants: 1
Project status: SIGNED

The growing demand for AI computing power is critically unsustainable with current energy-hungry computational hardware. Neuromorphic computing, leveraging complex dynamics of physical systems to perform AI, has emerged as a hugely promising approach to tackling this issue. However, existing neuromorphic schemes employ a single physical system, and fall short when computational tasks are not well-matched to the specific system dynamics. For the field to progress and provide real answers to global AI energy consumption, there is urgent need for innovative solutions capable of high efficiency and versatility across diverse tasks. In MORPHON, I propose a new paradigm: a ‘hybrid' neuromorphic approach that leverages the complementary strengths of multiple physical systems, delivering a new class of energy-efficient, task-adaptive neuromorphic AI hardware. I will show that photonic semiconductor networks which host many nonlinearly-coupled lasing modes can be sensitively controlled by optically-switched nanomagnetic arrays, with strong preliminary data confirming the promise & feasibility of my approach. Leveraging my deep expertise in nanomagnetism, photonics & neuromorphic physics, I will demonstrate that hybrid magneto-photonic networks hold the key to unprecedented neuromorphic performance: vastly-reconfigurable magnetic arrays provide memory and task-adaptivity, and photonic lasing dynamics grant exemplary nonlinear vision processing. My hybrid systems will perform a wide range of bio-inspired AI tasks, including challenging image classification & medical diagnosis, and neuromorphic video processing - a key unmet need in the field. MORPHON will ignite the next-generation of neuromorphic AI hardware, unlocking the potential of hybrid systems that far exceed the capabilities of each system alone. This project will radically advance physical neuromorphic computing while addressing the crucial global need for sustainable AI.

Keywords: nanomagnetism,magneto optics,neuromorphic computing,random lasing
Investigating how somatic mutation induced changes in the eutopic endometrial microenvironment cause endometriosis (MERMAID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus and chronic inflammation. Worldwide, >10% of reproductive-age women suffer from pain and/or infertility caused by this disease. Recently, cancer driver mutations have been identified in both the eutopic and ectopic endometrium of endometriosis patients. Moreover, it has been shown in cancer studies that cancer driver mutations can alter the local immune microenvironment. Nevertheless, it has never been studied how cancer driver mutations present in the eutopic endometrium of endometriosis patients contribute to the pathogenesis of this disease. Therefore, I propose to investigate how these mutations that are present in the eutopic endometrium alter the local eutopic immune microenvironment and thereby drive endometriosis development. This theory is what the acronym MERMAID in this proposal stands for: Mutations in Endometrial Regions and Microenvironmental Adaptations Influence Disease. To this end, I will analyze cell viability and immune cell signature in the menstrual fluid of people with and without endometriosis and identify which cancer driver mutations are present in their endometrial epithelial cells. In addition, I will create a mouse model to study the role of these mutations on the local immune microenvironment and in early endometriosis development. The outlined proposal will not only improve our understanding about the pathogenesis of endometriosis, but it will also generate potential new diagnostic methods and lead to novel personalized treatment options. Moreover, successfully managing this project will provide me with the additional scientific and translational skills necessary for moving up the career ladder towards a position as assistant professor in academia or senior scientist in industry.

Keywords: endometriosis endometrium cancer driver mutations immune microenvironment
HYBRID INTELLIGENCE FOR ADVANCED COLLECTIVE PERCEPTION AND DECISION MAKING IN COMPLEX URBAN ENVIRONMENTS (HIDDEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Greece,Czechia,Spain,Netherlands,United Kingdom,Germany,Cyprus
Call: AI for advanced and collective perception and decision making for CCAM applications (CCAM Partnership) (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 4997139.75
EU funding (EUR): 4997139.75
Participants: 16
Project status: SIGNED

Urban mobility poses various challenges to CCAM systems. Timely and reliable detection of occluded objects and especially vulnerable road users (VRUs) is a major one. To tackle this challenge, HIDDEN is developing advanced collective awareness (CA) and decision-making algorithms, with or without road infrastructure support. The CA system is focusing on the detecting occluded objects, including VRUs, while predicting their short-term trajectories using advanced behavioural models. In parallel, a novel driver gaze tracking and status monitoring system, is developed. The output of the CA and the driver gaze tracking is utilised by the real-time decision-making algorithms, which are designed to be explainable and aligned with human driving styles and ethical principles. HIDDEN deploys Hybrid Intelligence techniques across the whole chain, from perception till decision, to benefit from the combination of human with machine intelligence. During this process AI-related ethical and legal aspects are carefully considered via the development of a dedicated framework. HIDDEN developments will be evaluated both in real-world and in simulation. Real-world tests will be conducted with the AVs owned by the consortium (8 in total) in the respective testing facilities or on public roads, while for virtual tests novel co-simulation environments will be deployed. HIDDEN consortium has pre-selected four main use cases that drive the technical developments of the project. HIDDEN is developing CCAM systems which are not just technologically advanced but also deeply aligned with human driving styles, ethical principles and regulations, setting a new benchmark for the future of AVs technology. To increase HIDDEN’s impact, the consortium intends to reach out to CCAM stakeholders, in EU and beyond, engage in a continuous discussion with EU type approval authorities and UNECE working groups and promote mature results to standardisation.

Keywords: collective perception,collective awareness,human alligned decision making,short term trajectory prediction,complex urban scenarios,occluded objects detection,vulnareble road users
Proteomics-based Analysis of RSV nucleic acid/protein InteractionS (PARIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Respiratory Syncytial Virus (RSV) is a major cause of severe lower respiratory tract infections and a major cause of mortality in children under 5 years old and the elderly worldwide. While RSV impose a huge disease burden on public healthcare system, the development of effective vaccines and specific antivirals is impeded by a lack of knowledge of virus multiplications mechanisms, virus-host interactions or pathogenicity. Here, we propose to comprehensively map RSV-host interactions and characterize the cellular response to infection through an integrated multi-omics approach and using experimental systems close to natural infection. This project will combine my expertise in RSV biology and the host laboratory’s profound experience in systems biology analysis. By using state-of-the-art-of proteomics and transcriptomics, we will characterize the RSV RNA-bound proteome as well as the protein-protein interactome, analyze the proteome of cells expressing the individual viral proteins (effectome), and assess the influence of RSV infection on cellular mRNA expression, protein abundance, and phosphorylation. We will systematically map the identified viral-induced perturbations onto a network of known cellular protein-protein interactions and signalling pathways. This comprehensive network will highlight RSV-induced perturbations and pinpoint RSV host dependency-factors, whose functional importance and therapeutic potential will be assessed by conducting genetic and drug-based loss and gain of function experiments. Biochemical and structural methods, and further analyses of the cellular response in genetically or drug-perturbed cells will yield insights into the molecular function of selected proteins. The proposed multilevel approach will thus reveal yet unstudied proteins and pathways determining RSV growth, pathology or viral host defense mechanisms, which will shed light on unresolved questions of RSV biology, and reveal hotspots amenable to therapeutic intervention.

Keywords: rna viruses,virus host interactions,rna binding proteins
Framework Editing of Macrocycles Through Catalytic Olefin Metathesis (SHAPECHANGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-15
End date: 2025-01-14
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Bioactive macrocyclic compounds are valuable platforms in drug discovery. More often than not, natural products represent attractive leads, the structures of which may be altered by chemical synthesis to enhance efficacy, lower toxicity, and superior physicochemical properties. The proposed project aims to a practical and programmable strategy for precise skeletal editing of large ring structures by aligning catalytic ring-opening metathesis, site- and/or stereoselective modification of the linear intermediates, and formation re-formation of the macrocycle through catalytic ring-closing metathesis. The advance will significantly enhance our ability to navigate hitherto unexplored chemical space, needed for drugs discovery. The proposed investigations are centered on epothilone C, an important naturally occurring compound. We will to demonstrate the versatility of our approach by precise framework editing of this anticancer agent in a systematic way. The first phase will entail Z-to-E isomerization of the macrocyclic alkene, an alteration that will significantly change the molecule’s three-dimensional shape. This will be followed by site specific insertion of a methylene or a hydroxy methylene at one or both sides of the acyclic allylic sites. We will then re-close the ring. Similarly, ring contraction will be implemented through deletion of one or two methylene groups. Finally, ring expansion and ring contraction will be combined to achieve ring distortion.

Keywords: framework editing,macrocyclic natural products,epothilone c,olefin metathesis,ethenolysis,enantioselective allylic substitution,olefin isomerization,drug discovery
StarCom Optical Inter-Satellite Link. (StarCom OISL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Challenge: Customer-driven, innovative space technologies and services (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 3714062.5
EU funding (EUR): 2499999.0
Participants: 2
Project status: SIGNED

Mbryonics Ltd. is an independent Deep tech development company, based in Galway, Ireland, specialising in the design and manufacture of Optical terminals for Optical Intersatellite Links (OISLs) and Optical Ground Station (OGS) and adaptive optics systems. Technology leaders in the application of Freeform Optics for OISLs and Photonic Integrated Circuits in condensed packaging to enable PIC chiplet co-integration with electronics (ASICs/FPGAs) known as ‘co-packaged optics’ or ‘in-package optics’ for technology applications including: Intersatellite links, Telecom, Quantum Networks (QKD), Data Relay, Earth Observation and PNT Pointing, Navigation and Timing and Optical Feederlinks. Established in 2014, with almost a decade of experience developing high-tech solutions through integrated skills in the areas of ICT, photonics, optics, optoelectronics, adaptive optics and aerospace engineering, the team is ideally positioned to deliver advanced optical terminals and photonics solutions for a new era of proliferated space with the advent of mega constellations and a new market for space data over the next decade. Mbryonics are uniquely positioned with an innovative solution based on disruptive application of fibre-coupled free space optical communication (FSOC), silicon photonics and novel application of Additive Manufacturing of Freeform Telescopes and innovation in Assembly, Integration and Test (MAIT) which will overcome previous challenges for volume manufacturing of optical terminals. Mbryonics will utilise a Digital Twin to optimise MAIT and build lean processes to facilitate Sustainability objectives for 2030.

Keywords: freespace optical comms,freeform optics,quantum networks,quantum encryption,additive manufacturing,semiconductors,photonic integrated circuits,system in package,co packaged optics,silicon