Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transitivity in Indo-Aryan: A diachronic syntactic data base of valence-changing categories (TRIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The proposed project aims at combining quantitative, corpus based research with qualitative research on language typology and language change. In particular, I plan to provide a thorough description of verbal valency and of valency-changing categories in Old Indo-Aryan along with their development in Middle and New Indo-Aryan. The main tasks of the research are: (i) creation of an online free-accessible data base of early Old Indo-Aryan verbs based on data extracted from the Rgveda; (ii) a description of the diachronic development and balance of the different intransitivity markers in Indo-Aryan ranging from Old Indo-Aryan up to New Indo-Aryan. The data base of early Old Indo-Aryan verbs will provide a template for annotation of valency-changing categories in other texts. It will also contain data concerning the token and type frequency of verbs and verb forms. The diachronic analysis of the valency-changing categories in Indo-Aryan will be performed on a selection of verbs, and will serve as a basis for the typological study of these categories in a new perspective, particularly, for uncovering the stability of some categories and the expansion of some others, and thereby for determining what is constant in dynamic processes. The innovative and challenging character of the research is determined by its threefold perspective: (i) it will provide freely accessible resources for research on valency-changing categories in Old Indo-Aryan in their synchronic and (partly) diachronic aspects; (ii) together with similar works on other ancient Indo-European languages, it will offer a basis for the reconstruction of the Proto-Indo-European syntax; (iii) evidence from Indo-Aryan offers a possibility to study different features and developments within a group of related categories (passive, causative,etc.), being of particular relevance for a typological diachronic study of these categories.

Keywords: indo aryan,verbal valence,valence changes,data base,diachrony
Bacterial membrane vesicles a novel delivery system for the treatment of multi-drug resistant Gram-negative bacterial infections. (BacDrug)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Bacterial infections are a significant public health challenge and a major cause of human mortality globally. Antibiotics are indispensable for the treatment and prevention of infections caused by bacteria. However, global spread of drug-resistant bacteria, coupled with a dearth of new antibiotics in development has led to an alarming shortage of effective drugs. Gram-negative bacteria, in particular, protect themselves against antibiotics with a highly selective outer membrane. The high burden of diseases caused by Gram-negative bacteria, combined with their frequent multi-drug resistance has placed them as world´s highest-priority pathogens by the World Health Organization. Consequently, there is an urgent need for novel therapeutic approaches that combat Gram-negative bacterial pathogens. The goal of "BacDrug" is to use lipid-based bacterial membrane vesicles (BMVs) produced by non-pathogenic Lactococcus lactis as delivery system. BMVs have great potential as nanocarriers to by-pass the outer membrane and deliver their toxic payload to kill drug-resistant Gram-negative pathogens. A range of strategies will be used to load BMVs with cargo, including genetic engineering of L. lactis as well as chemical treatments. This Fellowship will harness expertise and techniques across microbiology, molecular biology, nanotechnology and drug design to deliver a successful outcome. The collaborative, truly interdisciplinary, cross faculty setting within the groups of Prof Molly Stevens (materials and bioengineering) and Dr Andrew Edwards (molecular microbiology) at ICL combines world-class expertise and provides an environment to maximise the success of this Fellowship, both in terms of the delivering the project and the training opportunities provided. Moreover, this innovative, alternative strategy to tackle drug-resistant Gram-negative bacterial infections has a high translational potential, which will be exploited via the clinical and translational research clinics at ICL.

Keywords: bacterial membrane vesicles,multi drug resistant,gram negative bacteria,anti microbial resistant,drug design
Envisioning the Reward: Neuronal circuits for goal-directed learning (SweetVision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1874780.0
EU funding (EUR): 1874780.0
Participants: 1
Project status: SIGNED

Our ability to learn relies on the potential of neuronal circuits to change through experience. The overall theme of this project is to understand how sensory cortical circuits are modified by experience and learning. Recent results have shown that learning the association of a visual stimulus with a reward modifies neuronal responses in primary visual cortex (V1). However, the cellular mechanisms underlying these experience-dependent changes remain largely unknown. Computational and experimental studies suggest that feedback pathways are crucial for adapting sensory processing by task demands, together with local interneurons that gate feedback through dendritic inhibition. I will test the hypothesis that feedback projections from higher level areas selectively enhance task-relevant information in V1 and that this process depends on dorsomedial striatal (DMS) output. Toward this aim, I am using chronic two-photon calcium imaging to monitor the activity of neuronal sub-populations in mouse V1, before, during and after two types of visual experience: a passive exposure to a visual stimulus and a rewarded visually-guided task. Published and preliminary results indicate that the representation of task-relevant features is enhanced and stabilised in V1 during learning while responses to non-relevant stimuli are suppressed. This project is organized around 3 aims: 1. To characterize top-down inputs to V1 neurons during passive and rewarded visual experience. 2. To characterize local circuits and single-neuron computation of task-relevant features within V1 3. To characterize the output of V1 neurons to higher cortical areas and DMS, during goal-directed learning. The expected results will show how behavioural training changes the neocortex to improve the encoding of behaviourally relevant visual objects. This project will uncover the circuits that are changed by and in turn dynamically gate relevant sensory information when an animal is learning a goal-directed task.

Keywords: visual cortex,calcium imaging,two photon imaging,awake behaving mice,virtual reality,reward,dendrites,inhibitory neurons,dorsomedial striatum,intersectional neuronal labeling,multimode fibre based imaging,endoscope
Models of Child Health Appraised (MOCHA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Iceland,Ireland,Ireland,Italy,Australia,Cyprus,Norway,Poland,Sweden,Switzerland,Netherlands,Netherlands,Netherlands,Netherlands,United States,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Developing and comparing new models for safe and efficient, prevention oriented health and care systems (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-11-30
Duration (months): 42.0
Total project cost (EUR): 6962265.0
EU funding (EUR): 6821232.25
Participants: 21
Project status: CLOSED

Children’s health affects the future of Europe – children are citizens, future workers, parents and carers. Children are dependent on society to provide effective health services (UN Convention on the Rights of the Child). Models of child primary health care vary widely across Europe based on two broad alternatives (primary care paediatricians or generic family doctors), and a variety of models of school health and adolescent direct access services. There is little research to show which model(s) are best, implying that some are inefficient or ineffective, with sub-optimal outcomes. MOCHA will draw on networks, earlier child health projects and local agents to model and evaluate child primary care in all 30 EU/EEA countries. Scientific partners from 11 European countries, plus partners from Australia and USA, encompassing medicine, nursing, economics, informatics, sociology and policy management, will: • Categorise the models, and school health and adolescent services • Develop innovative measures of quality, outcome, cost, and workforce of each, and apply them using policy documents, routine statistics, and available electronic data sets • Assess effects on equality, and on continuity of care with secondary care. • Systematically obtain stakeholder views. • Indicate optimal future patterns of electronic records and big data to optimise operation of the model(s). The results will demonstrate the optimal model(s) of children’s primary care with a prevention and wellness focus, with an analysis of factors (including cultural) which might facilitate adoption, and indications for policy makers of both the health and economic gains possible. The project will have a strong dissemination programme throughout to ensure dialogue with public, professionals, policy makers, and politicians. The project will take 42 months (36 of scientific work plus start up and close), and deliver major awareness and potential benefit for European children’s health and healthy society.

Keywords: child health,primary health care,family practice,primary secondary care interface,optimising services,school health,adolescent services,population health,efficiency,economics,implementation
QUantum Electronics Science and TECHnology training (QuESTech)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Spain,Germany,Switzerland,Finland,Sweden,Finland,France,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 3884019.12
EU funding (EUR): 3884019.12
Participants: 14
Project status: CLOSED

Quantum Electronics provides a challenging and innovative multidisciplinary framework for training young researchers with excellent prospects for a career either in the industry or in academia. In this promising area, the “Quantum Electronics Science and Technology training” project, with acronym QuESTech, will create a European network of experts providing state-of-the-art training for young researchers in the general field of experimental, applied and theoretical Quantum Electronics. The overarching science and technology goal of our research programme is to build, study, and qualify quantum electronic devices. QuESTech will train 15 ESRs through research in the sub-fields of spintronics, single-electronics, quantum dots, and quantum thermodynamics. The individual research projects will include technological developments in terms of nanomaterials growth, nano-structuring, near-field microscopies, transport measurement under extreme conditions and theoretical calculations. Several QuESTch results are already identified to be of commercial interest for the emerging Quantum Electronics industry. Systematic secondments will be organised, including for every researcher a secondment of two months to a private sector partner. QuESTech will organise three sessions of the European School On Nanosciences and Nanotechnologies (ESONN) devoted to Quantum Nano-Electronics, combining both theoretical and practical training, and open them to young researchers outside the consortium. By 2021, we aim to have prepared a new generation of young researchers able to address the emergence of “Beyond C-MOS“ nano-electronics.

Keywords: quantum electronics,quantum thermodynamics,quantum dots
Smart Irrigation Control System with 40% Savings in Water for Universal Use (IRRISAVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Israel
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

YODFAT Engineers is a company specialized in providing novel, unconventional solutions to complex environmental and civil engineering challenges. In the last years the company has been working in the development of IRRISAVE system, an innovative solution: reaching up to 50% savings in water and energy through a system that will accessibly transform the irrigation networks management forever. IRRISAVE is an innovative smart technology that maximizes the efficiency in water application. IRRISAVE integrates an intelligent software to control the soil water level avoiding water wastage and improving sustainable crop production. Introducing IRRISAVE systems will provide a universal and friendly user technology that will have a huge impact on fertilizers and energy savings as well as avoiding water table pollution for all irrigation methods. This cost-effective and user friendly system can make end users (agri and urban systems) save up to 1.200€ per hectare yearly.

Keywords: smart irrigation,water,water management,efficiency,active root zone
Re-orienting development: the dynamics and effects of Chinese infrastructure investment in Europe (REDEFINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2497726.0
EU funding (EUR): 2497726.0
Participants: 1
Project status: SIGNED

REDEFINE will examine what China’s rise means for how we understand global development and, specifically, Europe’s place in it. After 15 years of ‘going out’ to access raw materials and new markets, often in the global South, China is making assertive moves into developed economies, which were boosted by the Belt and Road Initiative linking China to Europe. At the same time, many European economies stagnated following the 2008 financial crisis with governments cutting infrastructure investment and seeking alternative sources of finance. China now sees Europe as fertile ground for new infrastructure investment, yet many European firms and governments are ill-equipped to deal with these political and economic changes. The first wave of Chinese internationalisation into the global South has been analysed largely from the perspective of international Development Studies. In the current phase, China’s move westwards radically questions the meanings and loci of development. REDEFINE’s innovation is to use insights from international development to interrogate Chinese engagement in the heart of Europe and by doing so re-orient the Eurocentric debates in the social sciences around how we define and delimit development, who drives these processes, and what it means for societies affected by such investments. REDEFINE’s aims require a disaggregated approach to unpack project-by-project effects, which will be undertaken using an assemblage methodology. Through comparative, ethnographic case studies in the UK, Germany, Greece and Hungary REDEFINE will produce fine-grained analysis to understand the rationales for Chinese investment in Europe, the geopolitical dynamics surrounding these financing streams, the structuring of projects, and how they interface with national and local development policy. By better understanding how investment deals operate, REDEFINE will connect Chinese and European government and corporate actors in order to influence their strategies and practices.
A PROOF-OF-CONCEPT FOR THE IMPLEMENTATION OF A EUROPEAN COPERNICUS COASTAL FLOOD AWARENESS SYSTEM (ECFAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Greece,Greece,France,Portugal
Call: Copernicus evolution: Research activities in support of the evolution of the Copernicus services (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 9
Project status: CLOSED

The increasing number of tools and algorithms able to process and extract qualitative and quantitative information from Earth Observation products has an enormous potential to support the evaluation of weather-induced climate risks. The ECFAS project will contribute to the evolution of the Copernicus Emergency Management Service by demonstrating the technical and operational feasibility of a European Coastal Flood Awareness System. ECFAS will provide a proof-of-concept that will complement and broaden the currently available panoply of core service information. ECFAS will evaluate coastal flood risk contributing to a fully integrated risk cycle monitoring service. ECFAS will implement an awareness system for coastal areas (preparedness phase) and impact assessment products (response phase), fundamental for effective recovery and prevention actions. Following the principles of subsidiarity and proportionality, the avoidance of duplication, and the facilitation of user uptake, ECFAS will capitalise from the product portfolio of CEMS, CMEMS and CLMS, publicly available datasets and information derived from relevant EU projects. Marine forcing forecasts will be improved through the integration of available models in order to reduce uncertainties and provide reliable coastal flood maps. Hazard and impact assessments will be carried out taking into account the existing CEMS framework and adding the impact on low-lying areas, that represents a set of added value mapping products. The technical operational feasibility of the products will be demonstrated through a performance assessment of the service in selected test cases for past-events, as well as in forecasting mode. The integration of data from different sources will require increased computer resources, supporting the concept of using DIAS as core processing service. The availability and accessibility of generated data and derived products will stimulate their exploitation by users of the Emergency Service and beyond

Keywords: coastal flooding,coastal risk,coastal vulnerability,coastal erosion,marine storm forecasting,shoreline displacement,storm impact,early warning systems
Development of pyrrolizidine alkaloid detection methods for the assessment of food contamination and impact on human and animal health (PATOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-18
End date: 2018-01-17
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Pyrrolizidine alkaloids are more than 600 individual compounds that are hazardous for animals and humans if ingested. The 3% of the flowering plants produce these type of molecules and grow as weeds in agricultural production systems throughout the world where they can contaminate commonly consumed foods (eg. grain, milk, meat, eggs, honey, pollen). Chronic exposure to low concentrations of these alkaloids can be the cause of progressive, chronic disease (hepatic damage, vascular obstructive disease, and cancer) that may be difficult to attribute to their presence in food. The 2007 statement from the European Food Safety Authority calls to generate more quantitative data sets on pyrrolizidine alkaloids levels in milk and honey, and to determine which PA plants and/or marker PA need to be considered relevant in animal feed. In the same direction, this Authority pointed in 2011 that toxicological data for pyrrolizidine alkaloids commonly found in honey was needed. Even though some countries have regulated the concentration of pyrrolizidine alkaloids in herbs used in traditional medicines, a general European legislation regulating the concentrations of these alkaloids in food is still pending. The present project propose the use of state of the art technology (UPLC-Qtof-MS, antibody microarrays) to better understand the distribution of pyrrolizidine alkaloids producing plants in relation to food content, and determine the incidence of exposure to these molecules in humans and animals. The results will impact several levels of society, the scientific results will provide science legal advisors with solid data to better inform law makers in the regulation of pyrrolizidine alkaloids in food, society will gain knowledge on the exposure to this type of molecules and on hazardous dietary habits, and food industry will benefit through the introduction of practices to avoid pyrrolizidine alkaloids containing components in food.

Keywords: pyrrolizidine alkaloids,food contamination,chemical and biochemical detection methods,metabolomic analysis