Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultra-Low Power and Highly-Scalable Interfaces for the Internet of Things (ULPIoT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Singapore
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2020-02-28
Duration (months): 36.0
Total project cost (EUR): 247728.6
EU funding (EUR): 247728.6
Participants: 2
Project status: CLOSED

The era of the Internet of Things (IoT), in which every physical entity includes power-autonomous embedded electronics, capturing relevant information by sensors and interacting with objects and humans in a globally interconnected network, is bringing about new challenges in Integrated Circuit (IC) design. The performance of ICs in terms of integration density, power consumption and cost, in fact, is the only limiting factor to the feasibility and/or to the widespread diffusion of IoT-based solutions. Digital ICs in the most recent nanoscale CMOS technologies are keeping the pace of IoT requirements. On the contrary, the implementation of analog functions, which are however essential to acquire data from sensors, thus enabling the interactions of IoT nodes with the surrounding environment, is nowadays the real bottleneck and the most serious concern and limiting factor for the further development of IoT applications. In the foreseeable future, the planned device scaling and voltage reduction down to near threshold (e.g. 0.4-0.5V) makes the design of analog circuits extremely hard, in view of the degradation of signal-to-noise ratio, matching and linearity. Despite of device shrinking, traditional low-voltages analog circuits do not really scale down in size, and occupy a more and more relevant percentage (i.e., cost) of the die area. In this scenario, the proposed research activity is intended to substantially enhance the scalability of analog blocks with technology and voltage by re-thinking analog functions in ICs in digital terms. In a new cross-domain approach, design and testing methodologies from the digital world will be extended and frontier design concepts like near-threshold operation further exploited. The effectiveness of the proposed approach will be verified and validated on IC demonstrators and with reference to a full SoC for wearable electronics applications in the development of novel IoT solutions.

Keywords: integrated circuit ic design,ultra low power,internet of things iot,digital ics,ics interfaces,device scaling and voltage reduction
Proof of concept and pre-commercialisation of personalised liquid biopsies in cancer therapy (BiopSense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 149999.99
EU funding (EUR): 149999.99
Participants: 1
Project status: CLOSED

Extremely high sensitivity is needed for the detection of cancer biomarkers during the follow-up of the treatment or post-operation period. We have identified a novel technology that enables very sensitive detection of single-nucleotide polymorphism from blood, enabling point-of-care screening of liquid biopsies. Our diagnostics platform will consist of new chemistry and device, and is an open system for designing new diagnostic targets. This will enable customized follow-up of the cancer medication in local hospitals and health care centers. The technology is based on our invention (US patent allowed) further developed in the ERC CoG project, but will have features for automated sample preparation and lab-on-chip design, which need to be verified and combined in the complete platform. For pre-commercialization of the technology, the sensitivity and accuracy of the chemistry will be determined and compared against competing mass spectrometric platform (UltraSEEK by Agena), upgrading our technology from phase TRL 4 to TRL 5. Patent shield of the technology is extended and options for transferring IPR from the University are clarified. Results are presented in investor convention and oncology conferences, and negotiations with investors and out-licensors are started. Three international biotech companies take part in the steering group. The technology allows business potential in device and kit production, but especially in international service business for personalised panel components and medical consultation. The expected price of the device and sample prep will be 30-40% cheaper than that of the closest competitor, but even better it allows flexible design of personalized diagnostic panels. The development for boosting the innovation to market will continue either through a spin-out supported by international investors, together with partnering companies, or through out-licensing.

Keywords: diagnostics,cancer,liquid biopsy,genetic,monitoring,biomarker,microfluidistics,cmos,array,minisequencing,single base extension,therapeutics
Molecular mechanisms of cohesin-mediated sister chromatid cohesion and chromatin organization (CohesinMolMech)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

During S-phase newly synthesized “sister” DNA molecules become physically connected. This sister chromatid cohesion resists the pulling forces of the mitotic spindle and thereby enables the bi-orientation and subsequent symmetrical segregation of chromosomes. Cohesion is mediated by ring-shaped cohesin complexes, which are thought to entrap sister DNA molecules topologically. In mammalian cells, cohesin is loaded onto DNA at the end of mitosis by the Scc2-Scc4 complex, becomes acetylated during S-phase, and is stably “locked” on DNA during S- and G2-phase by sororin. Sororin stabilizes cohesin on DNA by inhibiting Wapl, which can otherwise release cohesin from DNA again. In addition to mediating cohesion, cohesin also has important roles in organizing higher-order chromatin structures and in gene regulation. Cohesin performs the latter functions in both proliferating and post-mitotic cells and mediates at least some of these together with the sequence-specific DNA-binding protein CTCF, which co-localizes with cohesin at many genomic sites. Although cohesin and CTCF perform essential functions in mammalian cells, it is poorly understood how cohesin is loaded onto DNA by Scc2-Scc4, how cohesin is positioned in the genome, how cohesin is released from DNA again by Wapl, and how Wapl is inhibited by sororin. Likewise, it is not known how cohesin establishes cohesion during DNA replication and how cohesin cooperates with CTCF to organize chromatin structure. Here we propose to address these questions by combining biochemical reconstitution, single-molecule TIRF microscopy, genetic and cell biological approaches. We expect that the results of these studies will advance our understanding of cell division, chromatin structure and gene regulation, and may also provide insight into the etiology of disorders that are caused by cohesin dysfunction, such as Down syndrome and “cohesinopathies” or cancers, in which cohesin mutations have been found to occur frequently.

Keywords: cohesin,ctcf,higher order chromatin structure,mammalian cells,protein biochemistry,sister chromatid cohesion,tirf microscopy,xenopus egg extracts
Distributed control and simulAtion platform to support an Ecosystem of DigitAL aUtomation developerS (Daedalus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Austria,Spain,Italy,Italy,Italy,Switzerland,Sweden,Switzerland,United Kingdom
Call: Digital automation (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 5079796.25
EU funding (EUR): 3994296.0
Participants: 14
Project status: CLOSED

Daedalus is conceived to enable the full exploitation of the CPS concept of virtualized intelligence, through the adoption of a completely distributed automation platform based on IEC-61499 standard, fostering the creation of a Digital Ecosystem that could go beyond the current limits of manufacturing control systems and propose an ever-growing market of innovative solutions for the design, engineering, production and maintenance of plants’ automation. The following objectives will be reached: -)Ease the conception, development and distribution of intelligence into CPS for real-time execution of orchestrated manufacturing tasks; -)Foster interoperability of CPS from different vendors at orchestration-level (= “between CPS”); -)Simplify the design, implementation and integration of optimal coordinating control intelligence of CPS; -)Enable near-real-time co-simulation of manufacturing systems as a fully integrated “service” of a CPS; -)Create a Digital Marketplace to simplify the matchmaking between offer and demand within the Ecosystem; -)Conceive a multi-sided business model for the Automation Ecosystem and the corresponding business plans for its Complementors; -)Foster the widespread acceptance of the Ecosystem platform to guarantee success and impact of Daedalus multi-sided market. The project approach is based on 3 technological pillars, one platform pillar and a final ecosystem pillar: 1)IEC61499-based reconfigurable automation platform for distributed orchestration of interoperable CPS; 2)“Simulation-as-a-service” for integrated near-real-time co-simulation of CPS behavioural models; 3)Advanced SDKs for simplified design of hierarchically distributed optimal control applications; 4)Digital Marketplace for the creation of an interdependent ecosystem of automation solutions providers; 5)Proof-of-concept showcases to accelerate the involvement of “complementors” and the maturation of the Ecosystem.

Keywords: iec61499,distributed automation,co simulation,optima control,multi sided platform
Nanoscale Biomeasurements of Nerve Cells and Vesicles: Molecular Substructure and the Nature of Exocytosis (NanoBioNext)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

I propose to develop and apply state of the art analytical methods to investigate cell membrane and vesicle substructure to elucidate the chemistry of the closing regulatory phase of individual exocytosis events. The general goal of this proposal is to develop a new brand of analytical nanoelectrochemistry (nanogap and nanopore electrochemical cytometry), combined with chemical nanoscopy imaging methods with STED and nanoscale mass spectrometry imaging. I propose to apply this to the questions of the nature of exocytosis and the chemistry that initiates the process of a short-term memory. We have recently discovered that most neurotransmitter release is partial via an open and closed vesicle release process and this allows new mechanisms of plasticity and synaptic strength to be hypothesized. I propose to (i) test if partial release is ubiquitous phenomenon, (ii) develop new nanoscale analytical methods to measure exocytotic release from pancreatic beta cells and a neuron in Drosophila, and to elucidate the substructure of nanometer vesicles, (iii) use these analytical methods in model cells and neurons to test the hypothesis that lipid membrane changes are involved in the initiation of the chemical events leading to short-term memory, and (iv) test the effects of drugs and zinc on plasticity of vesicles and exocytosis. This work combines new method development with a revolutionary application of chemical analysis to test the hypothesis that lipids play a previously unanticipated role in synaptic plasticity and the chemical structures involved in the initiation of short-term memory. As long-term impact, this will provide sensitive analytical tools to understand how changes in these chemical species might be affected in relation to diseases involving short-term memory loss.

Keywords: keywords electrochemistry,nano,vesicles,exocytosis,chemical imaging
The European Training Network on Informal Care (ENTWINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel,Italy,Italy,Sweden,Sweden,Sweden,Belgium,Belgium,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 4091894.28
EU funding (EUR): 4091894.2800000003
Participants: 27
Project status: CLOSED

Mostly due to increased longevity and medical advances, the needs of older/ill individuals for long-term care rise rapidly while the availability of informal caregivers decrease. Informal caregivers are those who provide unpaid care to a relative or friend with a chronic illness, disability or other long-lasting health or care need. This “Gare Gap” will create huge problems for the sustainability of European health care systems that rely heavily on the provision of informal care. The aim of ENTWINE’s multidisciplinary and inter-sectorial team is to investigate the broad spectrum of issues concerning the development and use of innovative psychosocial and technology-based interventions that support willingness and opportunity to provide informal care. WP 1 details the current and future caregiving challenges and motivations for diverse groups of informal caregivers and their care recipients, and society, in different countries that have different care systems by means of an intensive longitudinal cohort study (ENTWINE-iCohort). It will establish who needs support, what kind and when. WP 2 examines (1) whether specific interventions, services and technology-based interventions (eHealth, social robots) could empower caregivers and reduce their burden, and if so, (2) how best to deliver these interventions, services (e.g. internet platforms) and tools to sustain willingness to care, experience optimal outcomes of their role, and improve quality of life amongst informal caregivers. Methods include experiments, factorial designs, and persuasive profiling. WP 3 examines the implementation and dissemination of innovative technology-based tools and interventions. The focus is on overcoming barriers following a user-centered, stakeholder-driven implementation and agile science approach to promote the adoption and implementation of innovative technologies to support informal caregivers. ENTWINE represents a stepping stone towards sustainable informal care throughout Europe.

Keywords: informal care,ehealth,policy
Sustainable Performance for High-Performance Embedded Computing Systems (SuPerCom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1998918.75
EU funding (EUR): 1998918.75
Participants: 1
Project status: SIGNED

Computers increasingly intervene in critical aspects of our life related to health, safety, and security, resulting in (critical) software controlling functionalities or services with humans in the loop. This trend towards critical-function digitization brings huge benefits for society and rests two pillars: the use of high-performance parallel hardware as the only viable option to cover the highest-ever critical software’s performance needs; and the ability to provide sustainable (guaranteed) performance, instead of average unreliable performance. Failing to support both pillars prevents embedded computers from safely executing critical software potentially causing unacceptable risks or threats to human life. SuPerCom goes beyond current solutions, which face either major scalability limitations or cannot provide performance guarantees, and proposes a holistic multidisciplinary approach that addresses the challenge of providing high and sustainable performance with future embedded computers comprising high-performance hardware with unprecedented complexity levels. SuPerCom synergistically combines for the first time performance analysis, hardware design and statistical and machine learning techniques. With SuPerCom performance predictability and performance observability become first-class citizen hardware requirements, rather than being considered at the end of the design. SuPerCom also proposes statistical and machine-learning techniques to (i) deal with big amounts of performance data coming from hardware sensors and (ii) provide on-line optimizations to increase sustainable performance. SuPerCom breakthrough can have significant economic and societal impact by allowing embedded computers to use high-performance hardware with strong guarantees of sustainable performance. This, in turn, will allow executing a wide-variety of performance-demanding critical software like advanced driver assistance systems in cars or advanced medical devices with sound guarantees.

Keywords: performance predictability,embedded computing systems,processor architecture
Measuring Quality of Life in the general population and Roma minority in Romania: implications for health policies and economic evaluations (QoLRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2020-10-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The importance of health related quality of life (HRQoL) data in research, clinical practice and health policy has significantly increased over the past decade. EQ-5D-5L is one of the most widely used instruments to measure HRQoL worldwide. Nevertheless, the quality of life of the Romanian general population or ethnic minorities has never been assessed before with EQ-5D-5L. Here, I propose to use EQ-5D-5L to provide locally robust HRQoL data for Romania to support reimbursement decisions and public health interventions in wider and vulnerable groups, such as the Roma minority. A representative sample of the Romanian general population and Roma minority will be recruited and face-to-face interviews will be conducted to explore differences in HRQoL according to sociodemographic characteristics, socioeconomic status and ethnicity. Additionally, population norms and social preferences for different health states (tariff) for EQ-5D-5L will be obtained. The successful delivery of this fellowship will be ensured by a fruitful combination of my experience in quality of life and in psychometric properties of questionnaires with the expertise of Newcastle University in health economics and preference elicitation methods. This fellowship will nurture a dual transfer of knowledge between myself and Newcastle University allowing me to gain new skills in preference elicitation methods, economic evaluations and modelling, teaching and project management. Additionally, the 3-month secondment at the EuroQoL foundation will provide me the skills to successfully undertake fieldwork for population-based valuation studies. These combined experiences will enable me to develop an independent career as a researcher that will play a key role in developing health services research and in building HTA capacity in Romania.

Keywords: quality of life,eq 5d 5l,valuation study,social inequalities,vulnerable groups