Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Photocatalytic C–H Bond CF3-diazomethylation (CF3-DIAZOMETHYLATOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-04-18
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The main goal of this Marie Skłodowska-Curie (MSC) application is to develop a new photocatalytic C–H bond CF3-diazomethylation of aromatic rings with a new class of hypervalent iodine reagents. Our approach is enabled by the photocatalytic generation of a previously elusive electrophilic carbyne radical, which is able to induce C-H bond cleavage. Preliminary results suggest that the proposed transformation will be able to functionalize complex drug molecules and provide valuable CF3-diazomethylated drugs. The useful reactivity of the diazo functional group (C=N2) contained on these molecules will be exploited to develop: (i) a small library of novel tetracycline antibiotics; and (ii) a [18F] labelling process; we aim to provide a robust and simple strategy for the simple synthesis of 18F-fluorinated probes to impact positron emission tomography (PET) imaging. A key strength of this multidisciplinary proposal is the introduction of a secondment phase, in an academic group, to evaluate the [18F] labelling, and a collaboration with a pharmaceutical industry to discover new antibiotics. The development of this project will enable the Experienced Researcher (ER) to become a leader for the next generation in the field of chemical synthesis and (radio)fluorination techniques by using the C-H functionalization logic. The ER will be exposed to a wide range of cutting-edge chemistry and biomedical sciences in two Top European Institutions (ICIQ, CICbiomagune) that will aid the development of his future research programmes as independent researcher. The high impact results expected will be published only in top journals and presented in major international conferences. Ultimately, this MSC application will contribute to enhance EU scientific excellence and allow the applicant to become a leading scientist in synthetic chemistry to impact health care.

Keywords: photoredox catalysis,radical species,c h functionalization
Macro-Nanomedicine to Treat Metastatic Cancer (Meta-Targeting)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1979375.0
EU funding (EUR): 1979375.0
Participants: 1
Project status: SIGNED

Metastatic cancer is a complex and highly heterogenous disease, which is very difficult to treat. The aim of the Meta-Targeting project is to establish a holistic, rational and realistic nanomedicine-based approach to improve the treatment of metastatic breast cancer. Concrete objectives are: (1) the development of polymeric micelles which can be efficiently and stably co-loaded with three different drugs and with an imaging agent; (2) the use of physical and pharmacological means to modulate the vasculature and microenvironment in tumors and metastases; (3) the identification of imaging- and biopsy-based biomarkers for patient selection; (4) the incorporation of drugs to overcome cellular and microenvironmental multidrug resistance; and (5) the implementation of multifunctional micelles to enhance the efficacy of immunotherapy. It is envisaged that micelles loaded with in-house developed doxorubicin prodrugs are able to induce immunogenic cell death in tumors and metastases without causing systemic immunodepression, that co-loading with the angiotensin receptor inhibitor losartan helps to prime tumors and metastases for improved delivery (of micelles, immunomodulatory antibodies and T cells), and that co-loading with the P-glycoprotein inhibitor tariquidar assists in inducing immunogenic cell death, while avoiding typical anti-Pgp side effects, such as neurotoxicity. Physical priming with ultrasound and microbubbles will promote the delivery of micelles, antibodies and T cells to and into primary tumors. Imaging- and biopsy-based biomarkers are needed to allow for patient stratification, which is critically important to improve the clinical translation of cancer nanomedicines. The outcomes of the different project lines in Meta-Targeting will - alone and especially together - be truly transformative: they will contribute to scientific and clinical progress in nanomedicine, in tumor-targeted drug delivery, in immunotherapy, and in the treatment of metastatic cancer.

Keywords: cancer therapy,drug delivery,biomarker identification,multimodal imaging,combination therapy
ENABLING FLEXIBILITY FOR FUTURE DISTRIBUTION GRID (FLEXIGRID)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Switzerland,Bulgaria,Sweden,Switzerland,Türkiye,Bulgaria,Romania,Türkiye,Belgium,Netherlands,Luxembourg
Call: Flexibility and retail market options for the distribution grid (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2019-11-01
End date: 2023-08-31
Duration (months): 46.0
Total project cost (EUR): 10398905.0
EU funding (EUR): 8149228.0
Participants: 19
Project status: SIGNED

FLEXI-GRID will demonstrate cutting-edge technologies and innovative flexible markets enabled by advanced cross-platforms for local energy exchanges and providing flexibility to distribution system operators in order to ensure a secure, stable and affordable operations of electrical distribution grids for de-carbonising energy systems with high shares of renewables (up to and beyond 100%). By leveraging digital, smart grid technologies, IoT, blockchain, FLEXI-GRID will provide a transparent data management platform by broadcasting real-time information on the conditions of the network to optimise the observability of the grid and market functioning. The project’s geographical coverage, with four test sites in Bulgaria, Sweden, Switzerland, and Turkey, allows validating solutions in multiple market conditions, and ensures post project scalability, knowledge transfer, scaling and replication. The key demonstration activities include i) grid monitoring, control and flexibility intervention; ii) local energy exchanges and provision of grid services; iii) blockchain based energy exchange and provision of grid services; iv) flexibility measures and grid services provided by local energy storage, Power to Gas, Vehicle to Grid, and local renewable resources. It is the first time that small and medium size DSOs show interest to test innovative tools and solutions. The project is strengthened by collaborating with Canada and backed by financial institutions to ensure successful commercial paths of innovative solutions.

Keywords: block chain,flexibilities,distribution girds,digitalisation,renewable energy,vehicle to grid,power to gas,grid services
Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor (STREPUNLOCKED)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Croatia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-10-18
End date: 2021-10-17
Duration (months): 24.0
Total project cost (EUR): 147463.68
EU funding (EUR): 147463.68
Participants: 1
Project status: CLOSED

We live in an era where once miracle drugs – antibiotics, cease to be efficient. The rise of antibiotic resistance is an immediate major global issue. There are several layers causing the problem – misuse, overuse, lack of proper guidelines etc. The only long-term efficient solutions are – pushing more antibiotics and vaccines into the discovery pipeline. More than 70% of the naturally produced antibiotics used today come from non-pathogenic bacteria from the Streptomyces genus. These bountiful bacteria still have a lot to give, as only one-third of their secondary metabolite pathways are characterized. The rest of their potential stays locked away, i.e., inaccessible with the currently available approaches/tools. In STREPUNLOCKED project, we suggest a study of an up-and-coming pathway involved in the regulation of antibiotic production/resistance – adenosine diphosphate (ADP)-ribosylation. In order to achieve these aims, we will use a multidisciplinary approach that combines several latest mass spectrometry techniques and analyses, genetic approaches, molecular modelling and bioinformatics’ tools to characterize the novel ADP-ribosylation pathways, their signalling context, and their role in antibiotic production. Using the deep dive strategy in order to understand this pathway in Streptomyces would have multiple benefits: opening the doors to the new tool for manipulating the Streptomyces metabolism, lead the way to new lines of basic research, discovery and practical applications – such as new antibiotic compounds.

Keywords: streptomyces,adp ribosylation,protein post translational modification,nad,antibiotics production,macrodomain proteins,mass spectrometry
COmbined Solution of Metal HYdride and mechanical Compressors: DEmonstration in the Hysoparc green H2 MObility project (COSMHYC DEMO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,France,France,France,Denmark
Call: Scale-up and demonstration of innovative hydrogen compressor technology for full-scale hydrogen refuelling station (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3773858.75
EU funding (EUR): 2999637.13
Participants: 6
Project status: SIGNED

Hydrogen mobility is gaining unprecedented momentum through the deployment of passenger & heavy-duty FCEVs. Although the number of Hydrogen Refuelling Stations (HRS) is increasing, the development of a refuelling infrastructure remains a major issue. Today, the compressor is the most challenging component in an HRS in terms of costs and reliability. The COSMHYC consortium developed an innovative compression solution (which combines metal hydride and diaphragm compressors), specifically addressing the needs of H2 mobility. In previous research projects, comprehensive tests enabled this technology to reach TRL5. The solution is now ready for real-life validation within the COSMHYC DEMO project. The aim is to demonstrate that it is well adapted to commercial use for a wide range of H2 applications. The project includes design, construction and integration of the demonstrator in a new dual-pressure HRS supplied with green hydrogen from solar-powered water electrolysis. This HRS is a central part of HYSOPARC, a project implemented by CCTVI (a grouping of municipalities) near Tours, France, for driving regional development based on H2 technologies. The HRS will supply a fleet of 700 bar passenger vehicles, 350 bar utility vehicles and a 700 bar garbage truck. This project presents a great opportunity to demonstrate the effectiveness and versatility of the innovative compression solution. The consortium will achieve further innovations on the compression solution followed by a 15 month demonstration phase within the HRS. The compression solution will be CE-certified & will meet latest refuelling standards, incl. for hydrogen purity. An advisory committee will support the partners to validate the solution against the needs of end-users. Market entry will be prepared through a techno-economic analysis and extensive communication, dissemination and exploitation activities, maximising the economic, environmental and societal impacts of the project.

Keywords: hydrogen refuelling station,hydrogen mobility,diaphragm compressor,metal hydride compressor,hybrid compressor,energy efficiency,fcev fleet,renewable energy storage,dual pressure,demonstration
Personalized PREvention of Chronic DIseases (PRECeDI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Italy,Spain,Hungary,Netherlands,Netherlands,United States,Netherlands,Canada,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 792000.0
EU funding (EUR): 792000.0
Participants: 12
Project status: CLOSED

The aim of the Personalized pREvention of Chronic DIseases consortium (PRECeDI) is to provide high-quality, multidisciplinary knowledge through training and research in Personalized Medicine (PM), with specific reference to prevention of chronic diseases. There is a large consensus that PM is a driver of innovation for research and health care, and also for the health care system and industry as a whole. In order to harness the potential of this new concept, the PRECeDI consortium provides a cohesive framework for training staff from academic and non-academic (NA) institutions on research topics related to PM, with specific reference to the prevention of chronic diseases where there is a lack of substantial evidence, though the potential is huge. The acquisition of skills from staff will come from dedicated secondments aimed at training on research topics not available at the home institutions, and attendance to courses, workshops, seminars, conferences. The goal of secondment is to enable staff to make informed decisions for appropriately serve health care systems, new biotech industries and policy makers at the dawn of the post-genomic era PRECeDI is a multidisciplinary group of institutions working on different facets of PM, from basic research, to economic evaluations, health service organization, and ethical, social, and policy issues. The consortium is embedded in existing cooperation structures, such as the PerMed project and the Erasmus Mundus ERAWEB II program, with additional leading SMEs in Europe and Canada as beneficiaries. The consortium consists of 8 beneficiaries and 3 partners, of which 7 are academic institutions and 4 NA, including 2 SMEs. During 4-years, 23 ESRs and 7 ERs will be seconded to 11 institutions, where researchers will be supported by a team of leading EU scientists in PM-related disciplines. In the long run, PRECeDI will foster the integration of PM in the field of prevention, thus contributing to better health for Europe’s citizen

Keywords: personalised medicine,genomics,chronic disease,health systems
PERIOD - PERASPERA In-Orbit Demonstration (PERIOD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Germany,Germany,Belgium,Belgium,France,Netherlands,United Kingdom,Portugal
Call: SRC - Space robotics technologies (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 10
Project status: CLOSED

Space robotics technologies are maturing bringing new capabilities for In-Space Manufacturing and Assembly (ISMA). These capabilities will generate on-orbit services improving the orbital infrastructure creating in turn a very promising business opportunity in terms of market volume. The establishment of a European capacity is necessary for building this new space infrastructure and to capture a fair part of this market that could be otherwise monopolized by US firms. The concrete objectives of the project are focusing on the main levers to generate the capabilities, which are the further maturation of the space robotics technologies and the definition of an in-orbit demonstration to be implemented as soon as 2025. ESROCOS, ERGO and InFuse will be developed to TRL5 after an alignment of their perimeter to the demonstration objectives. The Standard Interconnects, at TRL5 at project start, will be tested in a benchmark for evaluating their performance. These SRC building blocks will be integrated in a breadboard at Airbus DS for supporting the system definition work. The PERIOD Consortium bringing together the competencies of Airbus DS, DFKI, EASN-TIS, GMV, GMV-SKY, ISIS, SENER and SpaceApps is proposing a very ambitious demonstration scenario and Factory concept. A satellite will be manufactured in the Factory to be designed in the study at SRR level and injected in LEO for being operated. The manufacturing includes the fabrication of an antenna, the assembly of the satellite components and its reconfiguration in the Factory. The demonstrator is accommodated on the ISS Bartolomeo platform which will be upgraded to extend the level of capability validation from assembly and manufacturing of structures to refuelling experiments. Dissemination activities will maximize the impact of the project toward the Space Community. This demonstration covers the short and mid-to-long term ISMA business cases and will support the transition into the in-space manufacturing paradigm.

Keywords: in space manufacturing and assembly,on orbit services,space robotics,orbital infrastructure,esrocos,ergo,infuse,i3ds,standard interconnects,orbital factory,bartolomeo platform
bringing coastal SUBsurface water SOLutions to the market (SUBSOL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Germany,Germany,Greece,Greece,Netherlands,Netherlands,Netherlands,Denmark,Denmark,Denmark,Denmark
Call: First application and market replication (H2020-WATER-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 4170008.38
EU funding (EUR): 3460565.24
Participants: 15
Project status: CLOSED

Coastal areas are the most productive and economically dominant regions of the world. The high water demand in these regions, however, puts tremendous pressure on their freshwater resources and ecosystems. This leads to problems like seasonal water shortage, saltwater intrusion, and disappearance of wetlands. Building on national, regional and European research and innovation programs, in the past five years, a set of innovative, practical concepts have been developed for protection, enlargement and utilization of freshwater resources in coastal areas. These subsurface water solutions (SWS) combine innovations in water well design and configuration, allowing for advanced groundwater management, and maximum control over freshwater resources. SWS have been successfully piloted by public-private partnerships. These full-scale pilots have demonstrated SWS capacity to support sustainable freshwater supply in coastal areas, energy reduction, food production, and financial savings. SUBSOL targets a market breakthrough of SWS as robust answers to freshwater resources challenges in coastal areas, by demonstration, market replication, standardization and commercialisation. The route to market includes business cases, market scans and capacity building in selected regions in Europe (Mediterranean, Northwestern Europe) and worldwide (USA, Brazil, China, Vietnam). SUBSOL will share experiences and outcomes with stakeholder groups through an online platform, that will be linked to existing networks, including EIP on Water. The SUBSOL consortium combines knowledge providers, technology SMEs, consultants, and end-users from across Europe. Our ambition is to introduce a new way of thinking in terms of water resources management, promoting the sustainable development of coastal areas worldwide. This will stimulate economic growth and will create market opportunities and jobs for the European industry and SMEs.

Keywords: freshwater management,coastal areas,salinization,innovation,ecosystem services,technology assessment,commercialisation,salt water intrusion,public private partnerships,capacity building
Boost Of Organic Solar Technology for European Radiance (BOOSTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Slovakia,Switzerland,France,Czechia,United Kingdom,United Kingdom,United Kingdom,Canada
Call: Next generation of thin-film photovoltaic technologies (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 8196473.75
EU funding (EUR): 6106623.75
Participants: 12
Project status: SUSPENDED

In the context of increasing energy demand, thin film PV technologies contribute in reducing CO2 emission. Current PV technologies are suffering from several issues: 1 – the outsourcing of PV modules outside Europe, 2 – the large distance between consumption points and generating power plants and 3 – the use of agricultural fields by solar power plant. In this context, building applied photovoltaic (BAPV) approach can face these issues by bringing functionalization to facades or roofs with a small constraint on the building. BOOSTER project targets at deploying the OPV technology to the BAPV market. OPV is a technology that addresses the problematic of world energy production with an eco-responsible approach. Manufacturing OPV modules via printing techniques features a low energy-payback-time and uses resources that are abundant, easily accessible and non toxic. Additionally, OPV demonstrates properties (flexibility, lightweight) that make it easily suitable for BAPV. Recently, technology benefited from a rapid progress of performances with development of advanced materials. The project BOOSTER aims at bringing the OPV technology to a TRL 7 by increasing efficiency, lifetime together with optimizing costs and lowering carbon footprint. Two demonstrators will be installed to illustrated BAPV concepts: a “ready to stick module” and a textile integrated product. BOOSTER will provide an efficient multi-layer OPV architecture demonstrating efficiency up to 15 %. Advanced multifunctional barrier films will be manufactured to increase the lifetime to 35 years. With a large-scale production approach, efforts will be placed on scaling up all the materials and optimization of the R2R manufacturing line to coat all the layers with minimization of performance loss while targeting drastic cost reduction. BOOSTER BAPV products will be integrated in two different locations (FAU in Germany, ENI in Italy), where real-life efficiency will be studied during last year of the project.

Keywords: r 2 r,thin film photovoltaic,non fullerene acceptor,building applied photovoltaic