Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mixotrophy among small marine phytoflagellates – prevalence and impact on prokaryotic communities (MARIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2018-02-22
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Mixotrophy, i.e. the use of photosynthesis and prey uptake for growth, is increasingly recognized as a major trophic strategy for small (≤ 20 µm) phytoflagellates, which are responsible for a significant fraction of global primary production. In fact, marine primary production in many areas is now thought to be supported by organic P and Fe derived from prey. Despite this, a consistent picture of the overall relevance of bacterivory in open ocean and coastal mixotrophic small phytoflagellates (MSP) is lacking. Additionally, a strict dichotomy between `phytoplankton´ and `zooplankton´ is still overwhelmingly employed in models predicting the flow of matter and energy through marine systems, leading to potentially flawed and misleading predictions on ecosystem productivity and the health of global fisheries. This is especially significant when considering that anticipated environmental changes related to climate change are expected to shift the phototrophy/mixotrophy balance, with largely unknown consequences. The present study will combine culture and field work to 1) determine how shifts in environmental conditions related to e.g. season, influence coastal MSP abundance, identity and bacterivorous impact on the whole prokaryotic community, and on specific prokaryotic groups, such as unicellular cyanobacteria; and 2) analyze the importance and basic regulation of bacterial uptake for understudied coastal MSP. The proposed project excellently fuses the expertise areas of the experienced researcher, Dr. Anderson (bacterivory and predator-prey interactions), with the supervisor, Prof. Hansen (mixotrophic phytoflagellates) and the international collaborators, Prof. Jürgens (protist diversity and microbial food web interactions) and Prof. Scanlan (unicellular cyanobacteria), leading to an optimal exchange of knowledge for a successful project outcome. It will additionally restart and further the promising scientific career of Dr. Anderson after her maternity break.

Keywords: mixotrophy,protists,phytoflagellates,bacterivory,coastal marine systems
Reassessing Leibniz's conception of number and the infinite (REALE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 237768.0
EU funding (EUR): 237768.0
Participants: 2
Project status: SIGNED

The overall aim of the project is to investigate a neglected, though highly significant, topic in Leibniz’s thought: his general conception of number in light of his mereological theory. Special attention will be given to how this mereological background affects Leibniz’s conception of the infinite, and in particular his denial of the existence of an infinite number. In this way, the project will reshape the standard view according to which Leibniz’s rejection of infinite number is simply based on a faulty argument. On the contrary, the project’s ambition is to bring out – from Leibniz’s reflection on this topic – a (mereological) foundational theory for mathematics that can be seen as an alternative with regard to the standard set theoretical one. This topic has the potential to bridge the gulf now existing between an important mereological foundation of mathematics, as the Leibnizian’ one, with contemporary approaches – made in the 20th century by Lesniesky and his school on one side, and David Lewis’s Parts of Classes, on the other side – which exploit mereology to provide a less ontologically committed foundations for mathematics then set theory. The project can thus fill a gap in Leibniz’s scholarship and, at the same time, shed light on these contemporary attempts, and possibly revive some of their key aspects.

Keywords: mereology,conception of number,conception of infinite
Integrated Pest Management of the invasive Japanese Beetle, Popillia japonica (IPM-Popillia)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Austria,Austria,Germany,Italy,Switzerland,Switzerland,Switzerland,France,Portugal
Call: New and emerging risks to plant health (H2020-SFS-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-12-31
Duration (months): 52.0
Total project cost (EUR): 5489350.0
EU funding (EUR): 5489350.0
Participants: 13
Project status: SIGNED

The Japanese beetle, Popillia japonica, is one of the worst invasive pests of North America. Costs to control the pest in the US exceed $450 million per year. P. japonica was detected near Milano in 2014, and is now starting to spread in Europe. It is an enormous threat to Europe, since (1) it can feed on more than 300 host plants, including many important crops, (2) it is a good flyer and can be relocated via movement of goods and people, (3) climate suitability puts at risk an area ranging from the Atlantic to the Black Sea, and from the Mediterranean to Great Britain and Southern Scandinavia. EFSA and the JRC of the European Commission nominated P. japonica a candidate high priority pest in the EU in the new EU Plant health Law. IPM-Popillia has the aim to counteract this invasion. The project will provide fast and reliable monitoring tools, including an app-based citizen science approach to rise public awareness. Its main deliverable will be an IPM-Toolbox for control of P. japonica, relying exclusively on environmentally friendly control measures. Several teams of the consortium will collaborate in the core of the recent outbreak area, doing practical research in an European environment that can be applied immediatedly. The ambition of IPM-Popillia is to show that it is possible to control the new pest, and meet the requirements of quarantine regulations, and at the same time respect the environment and the principles of the sustainable use directive. IPM-Popillia will provide an integrated pest management strategy against P. japonica at a very early timepoint of the invasion process. So far, the new pest is still confined to one single and comparatively small area of about 6’000 square kilometres on mainland Europe. This timeliness is exceptional when compared to previous invasions into Europe, and will significantly enhance chances for successful containment, provided that the starting signal is given NOW.

Keywords: scarabaeidae,invasive,quarantine organism,entomopathogenic fungi,nematodes,monitoring,citizen science,phylogeography,genome sequencing,microbiome study,attract and kill,ecological modelling
Smart multisensor embedded and secure system for soil nutrient and gaseous emission monitoring (SARMENTI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Romania,Switzerland,France,France
Call: Electronic Smart Systems (ESS) (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 3979431.25
EU funding (EUR): 3979431.25
Participants: 8
Project status: SIGNED

SARMENTI develops a multisensor, low power IoT secure node to provide decision support to farmers by monitoring in real-time and in situ soil nutrients and gaseous emission. From this data measured on a daily basis over crop lifecycles, the farmer will timely perform appropriate actions regarding fertilisation, with direct impact on crop growth, soil & water quality and farmer income. The SARMENTI system will embed electrochemical sensors to measure e.g. NOx, POx, NH4, K, urea, pH, moisture, temperature. They will stay ideally during the crop lifecycle in the soil with packaging issues to protect them from their environment. A hygroscopic membrane will attract water from the soil, avoiding integration of a power hungry active pump usually used to exact water from a soil sample. SARMENTI will also monitor N2O (may appear in the nitrate cycle) and CH4 (generated by decomposition of manure under anaerobic conditions) just above the ground. These gases are greenhouse ones with higher warming potential than CO2. SARMENTI is part of the IoT (e.g. LoRa, BLE connexion). Data integrity is guaranteed by developing a secure node via combination of attack detection and automatic countermeasures application. Partners bring SoA prototypes of electrochemical and gas sensors and communication submodules, know-how in security for IoT nodes, and expertise in Agriculture. SARMENTI will further improve the prototypes (power, usage duration, hygroscopic membrane, packaging, sensitivity, selectivity) and integrate them with advanced processing in a connected secured device. Cloud Decisions support will allow evaluate the overall solution, SARMENTI demonstrator being tested in real fields. SARMENTI directly addresses ICT-7 challenge: “develop and validate new generation of cost-effective ESS ...”, RIA aim: “demonstrate ESS bringing intelligence ... integration of sensor systems, processors, computing and networking elements..." and “verification", "exploitation... clearly identified".

Keywords: electrochemical sensors,hygroscopic material,packaging,security for iot node
HUman EXoskEleton (HUMEXE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2023-11-30
Duration (months): 74.0
Total project cost (EUR): 1911875.0
EU funding (EUR): 1338312.5
Participants: 1
Project status: SIGNED

The objective of HUMEXE is to develop all the necessary stages to introduce in the market a new exoskeleton able toprovide full autonomy to patients suffering from paraplegia and improving current exoeskeletons available on market or atresearch stage. This new exoskeleton follows an entirely different approach for the movements control strategy. HUMEXE,as contrast to the rest of exoskeletons, bases the movement control of the lower limbs on the movement of the upper limbsof the individual, thus providing the user the full control of his movements, instead of being a control unit in control of themovements and their trajectories. This new approach will allow the user to control the lower limbs’ movements without theaid of crutches or the supervision of another person, and these movements will be performed more accurately thancompetitors’, thanks to the increase of freedom degrees of the exoskeleton (13, in contrast of a maximum of 10 and anaverage of 4 in other competitors). Besides it will reduce dramatically the computing requirements of the control unit,resulting in a simpler device, fail-safer and cheaper, easing the access to the exoskeleton to the general public.This new exoskeleton has been developed by Tecnimusa, a leading company on providing innovative engineering solutionsto their clients who can not find a satisfying one among the current solutions in the market. Tecnimusa is an engineeringSME, based on Murcia (southeast of Spain) and founded in 2011. Its main line of business is the providing and developmentof solutions consisting on the combination of different technologies to perform accurately their objective.

Keywords: exoskeleton,paraplegia,autonomous movement control
Synthetic Lethal Interactions with nucleophosMin 1 (SLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Less than 25% of patients diagnosed with acute myeloid leukemia (AML) survive longer than 5 years. Current treatment regimen are based on non-specifically acting cytotoxic drugs that cause severe side effects. More effective and more specific, targeted therapies are thus needed. Progress, however, has long been hampered by a lack of understanding of the molecular vulnerabilities of the disease. We here propose to identify and study synthetic lethal interactions with mutations in nucleophosmin 1 (NPM1) in AML. Up to 35% of AML patients bear mutations in NPM1 leading to a localization of this nucleolar protein to the cytoplasm and a characteristic change in gene expression pattern. Moreover, NPM1 mutations appear to be driver events and stable over multiple courses of therapy and relapse. Identifying cellular pathways or proteins that are essential in an NPM1 mutated background but not in NPM1 wild type cells may thus not only contribute to a better understanding of NPM1 biology but also yield entry points for the development of drugs that selectively kill NPM1 mutated AML cells. We will take an integrated chemical biology approach to first identify small molecules that selectively kill NPM1 mutated over NPM1 wild type cells and then elucidate their mode of action to gain insight into the underlying biology. This project thus uniquely builds on the longstanding experience of the host laboratory and institute in chemical screening, the elucidation of the mode of action of small molecules and in hematological malignancies. The proposal is designed to complement the experienced researchers current knowledge in chemical synthesis, assay development, solid tumor biology and small animal imaging techniques to become a well-rounded chemical biologist with a disease focus on solid and liquid cancers. The hosting institution will gain from the researcher´s chemical expertise and find opportunities to expand its network of international collaborations.

Keywords: acute myeloid leukemia,nucleophosmin 1,synthetic lethal interactions,chemical proteomics,high throughput screening
Renewables in a Stable Electric Grid (RE-SERVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Ireland,Italy,Ireland,Germany,Romania
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 4996652.5
EU funding (EUR): 4996652.5
Participants: 11
Project status: CLOSED

Future energy systems will use renewable energy sources to minimise CO2 emissions. Currently large generators powered by fossil fuel turbines maintain the stability and quality of energy supplies through their inertia. The inertia of these generator-turbine groups gives providers a significant time window in which to react to network events. We urgently need to find ways to stabilise energy systems with up to 100% RES (where inertia is often lost due to power converter mediated energy transfer) to generate “RE-SERVEs” so that society can relax in the knowledge that it has a stable and sustainable energy supply. RE-SERVE will address this challenge by researching new energy system concepts, implemented as new system support services enabling distributed, multi-level control of the energy system using pan-European unified network connection codes. Near real-time control of the distributed energy network will be enabled by innovative 5G based ICT. Energy system use case scenarios supplied by energy providers will form the basis of energy system models. Performance characteristics of the new control mechanisms will be investigated through integration of energy simulations and live 5G communications. We will create a pan-European multi-site simulation test-bed, bringing together the best facilities in Europe. RE-SERVE results include published models of system support services, innovative architectures for the implementation of the services, performance tests on our pan-European real-time simulation, and live, test-beds, a model for pan-European unified network connection codes and actions to promote results to standardisation organisations, all of which maintain the RE-SERVE in energy systems. Commercialisation of results will result in breakthroughs in the efficient utilisation of use of RES, a spin-off and a wide range of enhanced professional solutions and services.

Keywords: 5g based ict systems
Microscale Processes Governing Global Sustainability (MILEPOST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-12-31
Duration (months): 76.0
Total project cost (EUR): 2810198.0
EU funding (EUR): 2810198.0
Participants: 1
Project status: CLOSED

Reactive transport modelling is a key tool in understanding the extremely complex interplay of flow, transport and reactions occurring over various temporal and spatial scales in the subsurface. The most difficult challenge in reactive transport is the capture of scale dependence, and upscaling reactive transport will ultimately only be successful if there is a detailed understanding of fundamental mechanisms at the pore level and the supporting data are available. State-of-the-art tools (e.g. X-ray microtomography and on-chip porous media) are not sufficient to understand reactive flow, as they do not provide real-time mapping of propagation of fronts (e.g. temperature, pressure, concentration) that are critical to refine and validate simulations. The ambition is to progress beyond the state of the art via additive manufacturing tools to print 3D replicas of porous cores that enable monitoring the properties within the pores. Our unique approach is to develop for the first time three-dimensional instrumented replicas of porous structures, so we can gain much needed dynamic data at the pore scale that can be incorporated into validated simulations coupling flow and reactive transport processes. We combine expertise and integrating ground-breaking work in: (i) additive manufacturing to produce three dimensional replicas of porous structures; (ii) tools to embed sensors to determine in-vivo propagation of fronts (pressure, temperature, pH) within complex structures; and (iii) novel high-fidelity in-silico pore models coupling relative permeability functions and critical saturations with compositional changes and validated using virtual reality tools. The ERC MILEPOST project will transform our ability to analyse and predict the behaviour of a wide range of pore-scale processes governing the macroscopic behaviour of complex subsurface systems and open up new horizons for science in other areas, e.g porosity controlled in polymers and bioprinting.

Keywords: reactive transport,chemical rates,pore modelling
Microfluidics-assisted design and construction of light-responsive protocells (MicroLightProtoCell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Protocells are synthetic models of cells exhibiting rudimentary life-like properties, such as compartmentalization, sensing or replication, and constitute as such primitive forms of cellularity that could help to understand the origin of life. The remarkable properties of these smart micromachines can also be harnessed to tackle key societal challenges, including environmental clean-up, energy production, or drug delivery. Advances in this field would greatly benefit from the precise activation of protocells in both space and time. However, fine control over protocellular functions has been minimal to date. Conventional types of actuation (e.g. T, pH) do not allow spatiotemporal guidance due to their inherent inertia or the need to add chemicals. Light provides an attractive alternative for the remote manipulation of protocells with an extremely high spatiotemporal resolution. However, there is no precedent of light-actuated protocells in the literature. The aim of this proposal is precisely to design and construct a new class of photo-responsive protocells capable of being manipulated, activated or silenced quickly and locally in response to light. The bottom-up protocell assembly will be performed by microfluidics, whose powerful abilities in terms of modularity, reliability or sensitivity will be exploited to produce structurally well-defined architectures, and study interactions between protocells in a way unattainable with traditional methods. The expertise and skills of the applicant in the field of protocell design and light-responsive materials will be applied to the multidisciplinary and cutting-edge fields of microfluidics and synthetic biology in which the hosting groups at CNRS (under the leadership of Prof. Jean-Christophe Baret and Dr. Laurence Navailles) have made significant progress in the last few years.

Keywords: protocell,microfluidics,photoresponsive system,synthetic biology,coacervate,self assembly