Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOMOLECULAR CHARACTERIZATION OF STREPTOMYCES DIFFERENTIATION AND ITS RELATIONSHIP WITH SECONDARY METABOLITE PRODUCTION (STRP-DIFFERENTIATION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Spain
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-01-01
End date: 2017-06-30
Duration (months): 66.0
Total project cost (EUR): 1341985.0
EU funding (EUR): 1341985.0
Participants: 1
Project status: CLOSED

Streptomyces is a gram positive bacterium characterized by a complex developmental cycle. It is considered as a multicellular prokaryotic model that includes programmed cell death and sporulation. Streptomycetes are very important in industry, since they produce two thirds of clinically relevant secondary metabolites. Streptomyces and other bacteria with complex life cycles represent the evolutionary origin of some of the protein domains involved in the most important eukaryotic signalling pathways. The classical Streptomyces developmental cycle focused in the sporulation. Industrial fermentations are mainly produced in liquid cultures (large bioreactors), conditions in which there is not sporulation, and it was traditionally considered that there was no differentiation. During his predoctoral training, A. Manteca re-evaluated Streptomyces development in solid sporulating cultures, laying the foundation of a new research line about Streptomyces differentiation totally independent to the investigations of his PhD supervisor (Streptomyces nucleases). During his postdoctoral training, he continued working in this emerging research line analyzing the relation between differentiation and secondary metabolite production, reporting the first study in which antibiotic production could be associated with hyphae differentiation in liquid. Later, he focused in the proteomic analysis of Streptomyces differentiation, creating the most complete database about proteome variations associated with hyphae differentiation. The main objective of this project will be characterizing the biomolecular pathways behind Streptomyces differentiation, and their homologies and differences with eukaryotic signalling pathways. We will use the innovative developmental model elaborated by us and the information about the proteome differences during Streptomyces differentiation, to perform large scale mutagenesis and exhaustive phenotypic / bioinformatic characterization of these mutants.

Keywords: streptomyces,differentiation,programmed cell death,signalling pathways evolution,antibiotics,proteomics,transcriptomics
Development of a new functional antimicrobial edible film for fresh meat products. (MEATCOAT)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Belgium,France,Spain,Sweden,Romania,Germany,United Kingdom,Spain,Sweden
Call:  (FP7-SME-2011, 2011)
Start date: 2011-12-01
End date: 2014-05-31
Duration (months): 30.0
Total project cost (EUR): 2045348.4
EU funding (EUR): 1604600.0
Participants: 11
Project status: CLOSED

The main scope of the MEATCOAT is the development of a new functional antimicrobial edible coating for meat packaging to improve the integrity of products during distribution and commercialisation. The proposed system will increase shelf-life of the product due to their antimicrobial characteristics. The present proposal aims help end-user communities of SMEs: the fresh food industry (and particularly fresh meat sub-sector) by developing a new concept of edible coating that will enable a better preservation and quality of meat products and a longer shelf life in the market. The second community is the coating manufacturers, who need new products to launch to the market, to remain competitive and support their growth.These communities represents mature sectors in Europe with annual revenues valued in €40,456M and require continues effort in research and development to get products in a very competitive market to attend the consumer demand with increasing level of quality. A huge amount of fresh meat is disposed everyday from market selves. Better ways of preservation would avoid this and produce huge saves in the full supply chain. In addition, there is pressure to develop new products based on renewable sources that can replace present oil-based plastics whose recycling activity is inefficient and expensive. EC legislation is trying to curb the landfill disposal of recyclable or non-recyclable plastics, by encouraging the development of new products replacing recyclable or non-recyclable plastic packaging. As a result there are high levels of innovation in green packaging(lightweight and bio-based packaging materials). On the other hand, all new developments and innovations in the packaging industry will have to meet the current European standards and regulations for food contact materials, safety and public health (EC1935/2004, EC2073/2005 and EC450/2009), as well as the requirements of the REACH legislation.

Keywords: edible coating,biopeptide,self assembly peptide,meat,food preservation
More than color: Applying nanotechnologies for the multifunctional ceramic pigments development (NANOPIGMY)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Spain,Poland,United Kingdom,Italy,Spain,Spain,United Kingdom,Switzerland,Netherlands
Call:  (FP7-NMP-2011-SME-5, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 4631608.11
EU funding (EUR): 3299596.0
Participants: 9
Project status: CLOSED

The change in automobile and construction materials requirements has led industries to the modification of bulk materials with nanoparticulate additives or to the application of later high performance coatings in their materials to obtain better, cleaner, cheaper, faster and smarter products [1]. However, there still exist some barriers to nanotechnology-based products commercialization and use [2]: - Manufacturing processes make the processes more complex - High processing costs for nano-materials - Need of qualified manpower Modification of low-cost pigments could help to introduce nanomaterials (polymers, paints and concrete) in the market as manufacturing processes in automotive and construction sector would not be altered so there would be no need of qualified manpower. The high-performance pigment (HPP) market performed well in 2006 and continued to grow for a number of reasons but many of the raw materials used to manufacture HPPs increased in cost, thereby affecting the selling price of the finished goods to some extent. The price of high-performance pigments is significantly higher than classic pigments, and as a result, there are fewer producers of specialty pigments and higher margins for the products.The use of modified low-cost pigment will help to reduce the price of HPPs and consequently the price of nano-materials. NANOPIGMY project seeks to produce cost-efficient multi-functional ceramic pigments with more functionalities than color to give to the automobile and construction materials (plastic, paint and concrete) the required functionalities through the use of these nanotechnology-based pigments, avoiding thus changes in manufacturing processes.

Keywords: ceramic pigment,multifunctional,coating,nanoparticles
Ultrasensitive plasmonic detection of single nanoparticles (NANODETECTOR)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Germany,Germany,United Kingdom,Germany,Italy,Czechia,Switzerland,Germany,Lithuania,United Kingdom
Call:  (FP7-NMP-2011-SME-5, 2011)
Start date: 2012-06-01
End date: 2015-11-30
Duration (months): 42.0
Total project cost (EUR): 3848633.2
EU funding (EUR): 2967949.0
Participants: 11
Project status: CLOSED

Controlled or uncontrollabel disposing of nanoparticles in various components of man made or biological matter, may have wanted or undesired consequences. Developing the diagnostic tools to detect and characterize the ’grey goo’ is one of the challeneges of nanotech-era. A development of general technology for detection and analysis of single nanoparticles in complex environment and a development of a laboratory prototype of the device based on this technology and its application are the goal of this project. The proposal is based on the new experimental phenomenon discovered recently by a project partner: single subwavelength objects give rise to giant optical signals in surface plasmon resonance microscopy. This provides a unique possibility for ultrasensitive on-line detection of engineered nanoparticles. Within the project a development of the device for detection of nanoparticles and its application for a number of practically important tasks will be performed. The work includes a development of theoretical description of the new effect, optimization of main components of the detection system, development of sophisticated software for effective image analyses and isolation of nanoparticle signals from background optical signals and noise. Preliminary experiments demonstrated a possibility to use surface modification to distinguish different types of nanoparticles. Within the project this approach will be used for identification of nanoparticles. Measurements will be performed in aqueous media as well as in air. Inorganic, plastic and protein nanoparticles will be examined. At the final step of the project monitoring of nanoparticles in simple (drinking water, mineral water, air) and complicated (wine, juice and other transparent non-colloidal drinks) will be performed. The end users will test the developed experimental system for monitoring of workplaces and waste during production of inorganic and protein nanoparticles.

Keywords: nanoparticles detection,surface plasmon resonance
Innovative Sensor for the fast Analysis of Nanoparticles in Selected Target Products (INSTANT)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Germany,Sweden,Austria,Spain,Romania,Germany,Sweden,Finland
Call:  (FP7-NMP-2011-SME-5, 2011)
Start date: 2012-03-01
End date: 2015-11-30
Duration (months): 45.0
Total project cost (EUR): 4845125.74
EU funding (EUR): 3771946.0
Participants: 11
Project status: CLOSED

INSTANT will face the challenge of the detection, identification and quantification of engineered nanoparticles (ENPs) in complex matrices such as cosmetic products and engineered food and drinks. Therefore, new detection methods and technologies are mandatory. This is completely in line with the Call FP7-NMP.2011.1.3-1 which deals especially with innovative, practically implementable and cost effective measurement approaches for ENPs in complex matrices. Recently emerging ENPs include Ag, SiO2, TiO2, ZnO, and organic NPs. The “Opinion of the Scientific Committee on the Potential Risks Arising from Nanoscience and Nanotechnologies on Food and Feed Safety” released by the European Food Safety Authority (EFSA) (2009) also highlights the urgent need for such a tool. Accordingly, the interdisciplinary project INSTANT will develop an innovative and integrated technology for monitoring the exposure of consumers to ENPs using a label free opto-electrochemical sensor array in combination with novel recognition elements. The SME driven INSTANT will develop an innovative, cost effective, and easy to use analytical tool to extract, detect and identify ENPs typically used in cosmetic products (e.g. sunscreen, toothpaste, deodorant, ...) and engineered food (e.g. instant soups, ketchup, ice cream, ...) and drinks (e.g. fruit juice, energy drinks, bottled water, ...). A crucial point of measuring in these complex matrices is the sample preparation and extraction. Therefore INSTANT will develop and integrate tailored extraction methods. Especially the size distribution of ENPs in the sample and the influence of the matrix on chemical and physical properties of the ENPs have to be taken into account. The INSTANT device will be designed to be used as a cost effective monitoring tool which is suitable for characterisation and classification of ENPs for the future implementation of quantitative structure-activity relationship studies.

Keywords: electro- optical sensor array,engineered nanoparticles,molecular imprinted polymers,carbon nanotubes,food,cosmetics
Universal SEM as a multi-nano-analytical tool (UNIVSEM)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Czechia,Switzerland,Germany,Germany,Germany
Call:  (FP7-NMP-2011-SME-5, 2011)
Start date: 2012-04-01
End date: 2015-03-31
Duration (months): 36.0
Total project cost (EUR): 4988195.4
EU funding (EUR): 3596653.0
Participants: 9
Project status: CLOSED

The current scientific interest and next generation of nanotechnology-based products is combining converging fields and dealing with a large complexity (e.g. organic electronics, nanomedicine). We can see growing needs to visualize, manipulate, modify and characterize nano-objects in a single tool. The aim of the UnivSEM project is to develop a novel multimodal tool combining - a vision capability by integrating scanning electron (SEM), scanning probe (SPM) and optical microscopy (OM) thus enabling multimodal microscopy, - a chemical analysis capability by time-of-flight secondary ion mass spectroscopy (TOF-SIMS) and energy dispersive X-ray (EDX), - structural characterization by electron backscattered diffraction (EBSD), - a non-destructive optical analysis capability by confocal Raman spectroscopy and cathodoluminescence (CL), - a tomography capability by complementary use of novel 3D orthogonal TOF-SIMS, 3D EBSD and 3D confocal Raman tomography (the last method being non-destructive) thus enabling correlation between alternative 3D methods. The proper resolution will be ensured by SEM column improvements, a new SPM design and OM type of Raman microscopy in SEM. Implementation of nano-scale 3D imaging, manipulation and non-destructive optical analysis in one universal instrument will represent a real breakthrough allowing simple operations or analyses in nanotechnology that are problematic or impossible nowadays. The fully functional prototype of the new tool will demonstrate its unique modularity, resolution, data acquisition and simplification of working environment. Direct application of this multimodal tool is expected in many industrial quality controls and in R&D sectors (e.g. photovoltaics, plasmonics and cell-nanoparticle interaction).

Keywords: scanning electron microscopy,focused ion beam,elemental and molecular analysis in nanometres,scanning probes,spm,confocal raman microscopy,chemical imaging,3d tomography,tof-sims
Mitigation of risk and control of exposure in nanotechnology based inks and pigments - NANOMICEX - (NANOMICEX)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Spain,Spain,United Kingdom,Türkiye,Portugal,Belgium,France,Germany,Spain,Italy
Call:  (FP7-NMP-2011-SMALL-5, 2011)
Start date: 2012-04-01
End date: 2015-03-31
Duration (months): 36.0
Total project cost (EUR): 4800477.7
EU funding (EUR): 3535290.0
Participants: 13
Project status: CLOSED

The main aim of NANOMICEX project is to reduce the potential risk upon workers’ exposure to the engineered nanoparticles employed in the operative conditions of the inks and pigments industry, by addressing at the health and environmental consequences associated with the inclusion of nanoadditives within all stages of nanotechnology based products (production, use and disposal). To achieve it, new surface modifiers will be designed and developed to obtain less hazardous and more stable nanoparticles. The proposed work will focus on a selected set of nanoparticles relevant to the ink and pigment sector. Full characterisation will be carried out, followed by an exposure measurement in order to characterise and quantify any potential particle release in the production and processing activities. A comprehensive hazard assessment will allow the evaluation of effects on human and environmental models with comparisons between simple and modified nanoparticles carried out. Results from the assessment studies will be used to compile a risk assessment of the use of nanoparticles in the ink and pigment industry, and comparisons will be made with surface-modified nanoparticles. An evaluation of the effectiveness of risk management measures will be undertaken in order to select and design practical and cost effective strategies, which will be easy to implement in the real operative conditions. As part of this assessment, we will conduct a life cycle assessment, by evaluating their impacts during the whole process of manufacture, use and disposal of these products. The project results will involve industrial partners, providing an integrated strategy to mitigate the risk of workers dealing with nanoparticles, considering all relevant worker exposure scenarios. Furthermore, NANOMICEX will provide industrial stakeholders and the general public with appropriate knowledge on the risks of nanoparticles and nanoproducts, establishing synergies with the EU nanosafety infrastructure.

Keywords: environment,safety,workers,assessment,hazard,modifiers,nanoparticles,characterisation
Mucus Permeating Nanoparticulate Drug Delivery Systems (ALEXANDER)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Germany,Austria,Greece,United Kingdom,United Kingdom,Spain,Slovenia,Germany,Austria,Italy,United Kingdom,Germany,Finland,Netherlands,Austria,Spain
Call:  (FP7-NMP-2011-LARGE-5, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 11147592.65
EU funding (EUR): 8098202.0
Participants: 19
Project status: CLOSED

The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen.

Keywords: transport of nanocarriers through the mucus gel layer
Implantable Organic Nano-Electronics (IONE-FP7)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Sweden,Spain,Portugal,France,Netherlands,Switzerland,Czechia
Call:  (FP7-NMP-2011-SMALL-5, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 5090468.58
EU funding (EUR): 3834336.0
Participants: 13
Project status: CLOSED

The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs. The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response. The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model. iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.

Keywords: organic electronics,fflexible electronics,sensors,microfluidics,nanotechnology,stem cells,spinal cord injury,implantable devices,nanomaterials,animal model,ips,npc,inflammatory response.