Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Constructing the continuum-physics core of a digital twin for tribological contacts under boundary and mixed lubrication conditions (LubeTwin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 2453946.0
EU funding (EUR): 2453946.0
Participants: 1
Project status: SIGNED

A non-empirical continuum-physics-based digital twin for boundary and mixed lubricated tribosystems (the LubeTwin) would revolutionize the design and operation of sliding contacts in machines. Today, reliable continuum models of thermo-elasto-hydrodynamic lubrication (TEHL) are routinely used for component design. However, these standard TEHL models are considered to be invalid when the sliding surfaces are not separated by a thick enough lubricant film. My preliminary work suggests that TEHL can then still be applied provided constitutive equations (CEs) are employed that consider finite-size effects such as slip and lubricant layering at walls. Based on my hypothesis that the Reynolds lubrication equation works down to sub-monolayer lubricant films, the construction of a LubeTwin is proposed that quantitatively describes all microscale lubrication regimes in engineering sliding contacts – from dry sliding to hydrodynamic lubrication. This is achieved by a massive effort to produce a variety of atomistic benchmark data by molecular dynamics (MD) with non-reactive force fields for the lubricant rheology and with machine learning potentials for the lubricant-surface tribochemistry. Coarse-grained extreme-scale MD of lubricated µm-sized rough surfaces and high-throughput all-atom MD for nm-sized parallel channels will allow for an effective validation and training of novel physics-based CEs for an extended TEHL model. This makes the proposed LubeTwin a predictive tool linking nanoscale molecular structure of constituents to the friction of components at the macroscale. The final goal is to quantitatively describe lubrication in tribological experiments under high loads and to predict optimal conditions for super-low friction and wear in energy-efficient and sustainable machines. Embedded in a large interdisciplinary environment of multiscale modelers and experimentalists, a team of nine scientists will find ideal conditions to realize the vision of LubeTwin.

Keywords: tribology,friction,digital twin,extreme scale molecular dynamics,lubrication equations
Global-Ig: a population-based antibody library technique to optimize the development of globally protective vaccines (GlobalPROTECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 195000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

As the SARS-CoV-2 pandemic has demonstrated, vaccines that provide broad global protection are needed. However, human antibody genes are highly variable and thus, the quality of vaccine-induced responses can vary between population groups. This variation is shaped by the long history of host/disease interactions and differences in endemic diseases between regions over time, resulting in differences in antibody allele frequencies between populations. Therefore, information about how naïve antibody repertoires representing diverse population groups recognize vaccine candidates would greatly improve the development of broadly protective vaccines. In this Proof-of-Concept grant, we will develop a technique, Global-Ig, which allows in vitro production of large antibody libraries from a database of antibody germline gene variants representing the range of human global variation observed in the major population groups of the world, which we have assembled as part of our ongoing ERC Advanced project. Libraries representing different population groups will be used to prospectively identify differences in B cell recognition of candidate vaccines to facilitate selection of vaccine antigens that are broadly recognized. In cases where suboptimal binding to a vaccine antigen is detected for one or more population groups, the antigen can be modified to better accommodate population-specific alleles. Importantly, prospective screening against population-based antibody libraries in vitro offers possibilities to identify antigens that are broadly recognized prior to advancing candidates to clinical trials, substantially reducing costs associated with clinical development and improving health equity. Thus, the population-based Global-Ig antibody library technique described here represents an opportunity to harness information about human antibody germline gene variation gained in our ongoing ERC Advanced grant to select and tailor vaccine candidates for a global market.
Elevating Higher Education public policies: an empowering SPRIngboard (HESPRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Romania,Moldova, Republic of,Japan,Chile,France,Italy,Germany,Portugal,Kuwait
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1439800.0
EU funding (EUR): 1439800.0
Participants: 14
Project status: SIGNED

The current world of higher education (HE) has been shaped by two forces: the humanistic traditions of university governance and the neo-liberal reforms of the past thirty years. With its successes and discontents, this hybrid system faces major crises that affect its ability to respond to the needs of society: the tension between traditional and neo-liberal academic values; the biased evaluation and assessment of quality in higher education; the ineffectiveness determined by the distorted measurements of scientific achievements and other factors; the recent digital transformations of the universities facing the pandemic. To face these challenges, HESPRI addresses innovative strategies to strengthen public policies and improve the competitiveness of the HE sector. Specific objectives and originalities, and a well-designed R&I work plan (4 scientific WPs and 2 support WPs) are proposed for achieving this main goal: comparing a range of national HE systems worldwide as a function of cultural practices, for revealing tensions between various categories of values, shaped by global tendencies; exploring, defining and comparing quality in HE in different contexts, in order to provide innovative and advanced methodology; bringing the collective voice of science into the policymaking process in HE, by looking at how disciplinary and national differences affect governance; analysing technology-enhanced higher education environments, beyond the state of the art, around three pillars - digitalisation, metaverse and open science, on specific emerging research topics. Relying on a world-class and culturally diverse consortium, HESPRI aims to provide evidence-based recommendations for governments, policymakers and universities, to adjust various components in trend with recent provocations. The project proposal incorporates global digitalisation trends, and is tightly connected with world-wide and European strategies and programmes, such as the UN global policies of SDGs.

Keywords: higher education he policy,policy analysis,evaluation and assessment in he,he governance and interdisciplinarity,digital innovation in he and transfer to society,piloting
Developing neural crest organoids with inducible neuroblastoma to model chemoresistance in MYCN amplification related high-risk cases (NeuroblastORG)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Hungary
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 157622.4
EU funding (EUR): 157622.4
Participants: 1
Project status: CLOSED

Neuroblastoma (NB) is the most common cancer in infants and the 3rd most common cancer in children. According to the WHO 90% of NBs occur in children younger than 5 years old and 15% of all pediatric cancer related death are due to NB. Approximately 20% of NB cases are characterized by the amplification of the MYCN gene, which is linked to more aggressive tumors and poor prognosis (high-risk NB). Despite recent treatment advances, relapsing high-risk NB often leads to death. Understanding mechanisms of therapy resistance can help to develop more effective treatment protocols. However, investigation of acquired resistance upon chemotherapy is largely limited by the number of patients with high-risk NB and the availability of adequate model systems. Mice models of NB are often used, however species specific differences in sympathoblast development might result in misleading findings. Sympathoblast are the fetal counterparts of NB cancer cells and they are derived from the neural crest (NC). The overall aim of the NeuroblastORG project is to establish a human organoid model of the NC lineage, which can recapitulate human specific embryonic developmental stages, while also giving rise to sympathoblast-like NB cells, in addition to healthy sympathoadrenergic lineage derivatives (NB organoid). To reach this aim, human induced pluripotent stem cell lines will be genetically modified to overexpress the MYCN gene under the control of an NC-specific promoter, but only in a subset of NC cells within the organoids. Relevance of the established model will be validated by comparing gene expression signatures between NB organoids and human NB patient tumour samples. The NB organoid model system will provide a platform to simulate treatment of NB cells with NB-therapy relevant agents and monitor the effect of the applied treatment, allowing the investigation of human NB-specific chemoresistance acquisition in MYCN amplification related high-risk cases.

Keywords: organoids,neuroblastoma,disease modeling,drug resistance,genome editing
ENVIRONMENTALLY COMPATIBLE OPTIMIZATION OF EAF SLAG FOR LOW-CARBON ADVANCED GREEN CEMENT (ECO-SLAG-CEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland,Spain,France,Germany,Switzerland
Call: Towards cement and concrete as a carbon sink (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4569504.65
EU funding (EUR): 3991545.98
Participants: 9
Project status: SIGNED

The ECO-SLAG-CEM project aims to develop high-performance, low-carbon cements using modified Electric Arc Furnace (EAF) slag. The project addresses the significant CO2 emissions from the cement and steel industries, which together account for approximately 14% of global CO2 emissions. The primary objective is to enhance the reactivity of EAF slag through high-temperature treatments and bio-based activation systems, enabling the formulation of high-performance, low-carbon binders to replace the declining availability of granulated blast furnace slag (GBS).To achieve this, the project follows a twofold approach: high-temperature treatments to increase the intrinsic reactivity of EAF slags and the development of tailor-made activation systems, including the use of bio-based chelatants to pre-treat slags and accelerate hydration. A further focus of the project is the presence and mobility of Fe and heavy metals to ensure durability and compliance with environmental standards. The relevance to the work program lies in its alignment with the Horizon Europe Pathfinder Challenge "Towards cement and concrete as a carbon sink." The project aims to develop low-carbon binder technologies, optimize clinker reduction, and provide valuable data on the structure and behavior of Fe-bearing slags. By valorizing EAF slag, the project supports the decarbonization of the cement industry and adds value to the steel production process, making it easier to adopt globally and boosting the competitiveness of European steel production. The project involves collaboration between various partners, including universities, research institutes, and industry players, ensuring a comprehensive and interdisciplinary approach. The expected outcomes include the development of treatment strategies for EAF slags, the introduction of bio-based accelerators, and the formulation of high-performance hydraulic binders, contributing to the sustainability and competitiveness of the EU cement & steel industries.

Keywords: scm,cement,eaf cement,eaf,slag,low clinker,low carbon,decarbonisation,steel,byproduct,circular economy,bio based chelatants,bio leaching
Exploring Nuclear Aspects of Neutrino Interactions in Neutrino Oscillation Experiments (NeutrinoNucleai)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The ability of current and next generation accelerator based neutrino oscillation measurements to reach their desired sensitivity and provide new insight into the nature of our Universe, requires a high-level of understanding of the neutrino-nucleus interactions. These include precise estimation of the relevant cross sections and the reconstruction of the incident neutrino energy from the measured final state particles. Incomplete understanding of these interactions can skew the reconstructed neutrino spectrum and thereby bias the extraction of fundamental oscillation parameters and searches for new physics. This proposal exploit the similarity of electron- and neutrino-nucleus interactions. It leverages wide phase-space exclusive electron scattering data with known beam energies as well as neutrino scattering data in the same energy region and on similar nuclear targets, to test energy reconstruction methods and interaction models. The ERC NeutrinoNuclei project will deliver well constrained simulation environment and uncertainties of the neutrino-nuclei interaction, to meet the requirements of future high-precision experiments.

Keywords: neutrino,nuclear,lartpc,microboone,clas,oscillations,cross sections,simulation
Deciphering the roles of reactive oxygen species and calcium during viral infection in Arabidopsis (ViROSCa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

As sessile organisms, plants always have to deal with different environmental stimuli. The generation of reactive oxygen species (ROS) and calcium flux as second messengers are one of the common strategies to respond to such stimuli. Upon perception of pathogens, molecular warning signals (ROS and calcium) propagate cell-to-cell to trigger defence mechanisms. However, the precise roles of ROS and calcium during viral infection process and the associated signalling mechanism remain largely unknown. Viruses are obligate intracellular pathogens that hijack host machineries to facilitate their replication and propagation across the plant through plasmodesmata, communication channels bridging the plant cells. The ViROSCa project’s goal is to explore the mutual role of generated ROS and calcium signals and to study the crosstalk between the two signals during viral infection and later identify the virus element(s) that specifically induce(s) such signals. I will integrate Arabidopsis genetics, biosensors, genome editing technology (CRISPR/Cas9) and advanced microscopy techniques to decipher the roles of plasma membrane (PM)-located ROS- and calcium related candidate proteins and PM organisation (nanodomains) during the plant virus infection process. The novelty of the project is the use of a powerful pathosystem and biosensors to study the crosstalk between ROS and calcium signalling.

Keywords: reactive oxygen species,calcium,plant viruses,nanodomains and biosensors
Enabling efficient computation on fault tolerant quantum computers (COMFTQUA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-07-01
End date: 2025-12-31
Duration (months): 30.0
Total project cost (EUR): 4628617.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Our solution is an innovative suite of hardware-agnostic quantum algorithms, along with their hardware-aware implementations. Our solution will consist of a complete, multi-level set of techniques that reduce quantum circuits’ size and improve their fidelity when executed on real quantum hardware. We will enable relevant business problems, too difficult for conventional computing, to be solved several years earlier. The exemplary solution consists of: 1) Application layer with problem reduced (classically) to the form best suited for QC. [In case of routing this is parallel TSP reduced, for example to max 2-SAT] 2) Optimisation layer containing features guaranteeing optimal representation given problem size. This includes our decomposition techniques for multi-control quantum gates 3) Implementation layer guaranteeing optimal use of the hardware (this includes hardware aware implementation, taking into account the topology (qubit connectivity) and native gate set.

Keywords: quantum algorithms,fault tolerant quantum computers,quantum hardware,quantum computing,super polynomial speedup,efficient optimisation,quantum advantage,quantum supremacy
High-Performance Millimeter-Wave and Terahertz Components Based on Spoof Surface Plasmon Polaritons for Next-Generation Communications (MITCOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

The millimeter-wave (mmWave) and THz frequency bands hold immense potential for enabling ultra-fast data transmission and unlocking unprecedented bandwidth capabilities, but the RF components and circuits at these high frequencies suffer from relatively-large insertion losses and manufacturing difficulty/inaccuracy. Therefore, this entails researching into a fully-new type of transmission lines able to mitigate the high insertion losses and alleviate fabrication-tolerance issues of RF components. This MITCOM project aims to explore and develop new spoof surface plasmon polariton (SSPP) transmission lines for the design of mmWave and THz components with low insertion losses and their applications in next-generation wireless communications. Specifically, the overarching aim is to obtain SSPP-based mmWave and THz bandpass filters and multiplexers with low losses, low interference, high fabrication tolerance, ease of manufacturing and integration. Firstly, a new type of planar half-spaced SSPP transmission lines for waveguide and on-chip application scenarios will be proposed, and their design methodology will be developed to balance loss, ease of manufacturing and crosstalk issues, serving for E-plane waveguide and on-chip filter design. Then, the strategy for different filter specifications and tolerance levels will be analyzed in the steps of modeling and implementation through particular manufacturing technologies. Based on the design methodology and strategy, a series of E-plane waveguide and on-chip filters will be manufactured for validation and industry applications. Finally, based on the newly-conceived planar half-spaced SSPPs, diplexers and triplexers will be also designed, characterized and fabricated. The outcomes of the MITCOM project will contribute to the realization of cost-effective mmWave/THz filter and multiplexer products that potentially increase company profits and propel growth of the 5G/6G communication technology.

Keywords: millimeter wave,terahertz,components and circuits,spoof surface plasmon polaritons,e plane waveguide filters,on chip filters