Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimisation of a novel software tool for automation of the design & verification process of semiconductor development (OverSemi)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Challenge: Emerging semiconductor or quantum technology components (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3574621.25
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

If a defect remains undetected in the development process of a chip, it will be carried over to the physical production and will be present in every unit produced. If discovered too late, the manufacturer incurs in a loss that can reach billions. Even if it can be corrected, market entry would be delayed, resulting in additional losses. In a reality where the EU semiconductor market is lagging behind, LUBIS EDA is developing a software that ensures that future chips are developed more reliably, faster, and with a mathematically proven 0% chance of errors. By automating the design & verification process of chip development, LUBIS’ unique procedure enables exceptional cost-effectiveness and faster time-to-market for semiconductor developers, maximising their revenues and ensuring safe and reliable development. Within this project, LUBIS will optimise its software and make it accessible to a broader audience, enabling its market introduction through a licensing-based business model.

Keywords: chips,microchips,design and verification,integrated circuits,electronic design automation
Photodynamic Hydrogel for Encapsulated Release and Organoid-based Neu5Ac desialylation (PHERON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

Colorectal cancer (CRC) was estimated to be the second most commonly diagnosed cancer in Europe. CRC can be classified into subtypes based on distinct molecular and clinical features, termed consensus molecular subtypes (CMS 1-4). The proportion of CMS4 was 38.5% in CRC stage IV patients, only 6% of whom had a 5-year survival rate. CMS4 CRC is highly malignant and characterized by a richness of stromal fibroblasts and, consequently, an increased expression of mesenchymal genes. The sialylation of CRC stromal cells, as well as tumor cells and fibroblasts, has been verified as a key factor in forming the immunosuppressive tumor microenvironment (TME), which is also the main challenge for immunotherapy responses. Establishing multicellular CMS4 CRC spheroids helps unravel the mechanism of CRC TME and test the drug efficacy. 3Fax-Peracetyl Neu5Ac (SI) is a sialyltransferase inhibitor capable of reversing sialylation in the TME. It can disrupt the immunosuppression of TME through desialylation and thus activate T cells and natural killer cells (NK cells). A growing body of evidence has proven that sialylation-included glyco-immune checkpoints are more widespread in tumor tissue and have a greater potential for application than PD-1/PD-L1 and CTLA-4 inhibitors currently in use. Notwithstanding, nephrotoxicity remains an unsolved problem in its application. PHERON aims to develop a photodynamic liposomes-encapsulated hydrogel to achieve the controlled release of SI at the colorectal tumor site, through a novel CRC multicellular spheroid model.

Keywords: immunotherapy,colorectal cancer,nanoparticle,hydrogel,desialylation,phototherapy,drug delivery,pharmaceutics,organoids,spheroids,nanomedicine
CorPack - Turnkey building block for scaling novel wave energy technology into competitive utility-scale wave farms (CORPACK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Global electricity demand is set to double by 2050, with 90% expected to be generated by RES. Solar PV, wind, and storage are essential but will be insufficient alone to achieve net-zero. With 60% of the global electricity generation today being still dependent on fossil fuels, accelerating the transition to net-zero requires a RES diversification able to supply 24/7 demand for electricity with 100% clean power. Wave energy could supply 10% of the world’s electricity demand, playing a crucial role in a balanced and cost-effective RES mix. However, this potential remains untapped. Historically, wave technologies have either broken in the harsh ocean conditions or have been too large and costly compared to their power output. This has resulted in setbacks related to perceived risk and bankability. Informed by 40 years of hydrodynamic research, CorPower Ocean developed and proven at TRL 7 a unique Wave Energy Converter (WEC) technology that makes devices naturally protected in storms and uses novel control technology that strongly amplifies the power capture in regular waves. This allows to deliver more than 5x as much power per amount of equipment compared to the previous state-of-the-art. High structural efficiency enables simple installation and effective O&M methods, providing a very competitive LCOE-curve to make wave energy a mainstream energy source in the coming years. We design, manufacture, and deliver our technology as CorPack wave clusters with 10-30MW capacity. CorPacks are building blocks that are laid out side-by-side to form utility-scale wave farms (100s of MW to GW-scale). Now, we seek blended support from the EIC to standardize our core WEC technology so it can scale up into wave farms and to develop the engineering package of the CorPack product. The EIC will help us become a turnkey supplier of wave energy systems, reach FID on our first wave farm projects, and support CorPower’s ambitious target of installing 600MW of clean wave energy by 2030.

Keywords: ocean energy,wave energy,wave energy converter,wave energy farm
Scalable Mapping of Tumor Microenvironment Inspired by Geographic Information System (ScaleMAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Nonmutational epigenetic reprogramming and genome instability are hallmarks of cancer, intricately tied to the tumor microenvironment. Understanding these processes requires scalable, spatially resolved tools at the molecular, cellular, and histological levels. The purpose of spatial omics, similar to geographic information systems (GIS), is to enable the analysis of spatial relationships across complex biological features. In GIS, geospatial indexing allows us to effortlessly search for patterns and events—such as Dating Apps, Chat Apps or Proximity searches (Uber, Lyft, Yelp, Google)—using real-time updates and interactive maps. In contrast, current spatial omics technologies lack scalability, real-time integration, and interactive visualization. Scalable mapping of the tumor microenvironment at multiple levels is essential to decipher tumor progression and identify new therapeutic targets. Inspired by geospatial indexing, I will develop an interdisciplinary toolbox, ScaleMAP, for mapping single-cell spatial epigenetics and genomics within the tumor microenvironment. ScaleMAP offers high-throughput, high-resolution, scalable, and interactive mapping across large tissue sections. 3D reconstruction of ScaleMAP will enable the investigation of cancer evolution in three dimensions. Like Google Maps, ScaleMAP treats tissues as "biological terrains," allowing researchers to interactively zoom into specific areas of interest across molecular, cellular, and histological levels to extract valuable insights. We will also develop GIS-inspired analytical packages for ScaleMAP data. Furthermore, we will adapt ScaleMAP for formalin-fixed paraffin-embedded samples and apply it to clinically archived paired primary and metastatic colorectal cancer samples to dissect metastasis. Beyond cancer, ScaleMAP has broad applications in biological research and digital pathology, offering powerful tools for exploration, diagnosis, and therapeutic discovery.
Impact and viability of a novel mass PCR testing method as a pandemic-fighting strategy (PCR-4-ALL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Italy,Spain
Call: Pandemic preparedness (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 3397611.25
EU funding (EUR): 3397611.0
Participants: 5
Project status: SIGNED

The COVID-19 pandemic has not only affected our health, but also our lifestyles and our economies. Given its high non-symptomatic transmissibility, to stop a pandemic-causing pathogen like SARS-CoV-2 early on its tracks without needing to resort to economy-damaging measures, would have required a mass testing strategy very early on: according to some estimates up to 10% of a nation’s population should have been tested on a daily basis to achieve this. Given the exponential growth tendency of pandemic-causing respiratory viruses, as soon as such pathogen is identified a large-scale testing campaign should immediate be deployed (a strategy adopted successfully in very densely populated areas of China). And given the long periods required to develop other pandemic-fighting strategies (i.e. such as vaccines and quick diagnostic tests), PCR-based mass testing could be the ideal front line of defense, since it can be developed in only a few weeks after decoding the genetic map of the pathogen. But although PCR testing capacity has greatly been increased worldwide, regularly testing large fractions of the population would still remain prohibitively costly with current technology. The PCR-4-ALL consortium (combining expertise in diagnostics, high-throughput-screening, virology, disease modelling, econometrics and digital health platforms) will aim to demonstrate the technical feasibility of carrying out population-wide PCR testing by demonstrating a capacity of >10^5 tests in a single day and platform, in an extremely cost-effective manner (at least 2 orders of magnitude cheaper than currently). We will, furthermore, evaluate the effectiveness of utilizing this strategy as the main pandemic-fighting measure by assessing its ability to minimize, or even prevent, the need to implement other costly and partially ineffective measures (i.e. lockdowns and vaccination campaigns).
Explainable AI-Empowered Post-Disaster Network Outage Detection and Recovery in O-RAN-Enabled 6G Networks (X-AIDRON-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165205.2
EU funding (EUR): 165205.2
Participants: 1
Project status: SIGNED

The X-AIDRON-6G project aims to develop an innovative, autonomous framework for outage detection and network recovery in disaster-affected areas using a combination of Non-Terrestrial Networks (NTNs), Open Radio Access Network (O-RAN) architecture, Terahertz (THz) communications, and advanced 6G technologies. The primary goal is to ensure resilient communication systems by leveraging NTNs, including satellites and unmanned aerial vehicles (UAVs), which will complement cellular networks in the event of network failure. X-AIDRON-6G’s approach involves the integration of NTNs with cellular networks through O-RAN architecture, allowing for seamless interoperability. This integration will enable rapid detection of network outages and dynamic recovery, ensuring connectivity in disaster scenarios. Additionally, the project will utilize explainable artificial intelligence (XAI) and machine learning (ML) algorithms to detect outages in an explainable and reliable manner. Data collected from O-RAN interfaces and packet core will be used to train these AI models, enabling rapid response to network disruptions. Upon detection of a network outage, X-AIDRON-6G will optimally deploy UAVs and utilize existing satellites to restore connectivity. These UAVs will act as temporary access points, while satellites provide high-speed and capacity midhaul/backhaul to the ground stations through THz links. The combination of AI-driven outage detection and THz-enabled NTNs will ensure fast, scalable, and cost-effective network recovery. Moreover, zero-touch network automation vision of X-AIDRON-6G will enable rapid recovery in dynamic network conditions. X-AIDRON-6G is highly relevant to the objectives of 6G, contributing to more resilient, autonomous, and sustainable networks. X-AIDRON-6G’s outcomes will serve as a critical foundation for achieving global connectivity, especially in disaster-prone or remote areas, advancing the vision of a truly resilient and ubiquitous 6G system.

Keywords: open radio access network o ran,non terrestrial networks ntns,explainable ai xai,terahertz thz communications,zero touch network automation
Low strain rate Intraplate SEISMOgenic sources: Surface and sub-surface deformation interpretation and characterization of fault REACTivation during the Quaternary (SEISMO-REACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 2
Project status: SIGNED

SEISMO REACT aims to investigate Quaternary active faults, surface deformation, and the reactivation of large potential seismic sources in an intraplate setting, by combining data from geology, geomorphology, geophysics, and geochronology, in particular by applying a new method using trapped charges (Luminescence and Electron Spin Resonance) to investigate fault gouge geochronology and timings of fault activity. The seismogenic reactivation of older structures in an intraplate setting is a known tectonic condition worldwide, impacting Europe, Australia, Africa, and North America. Furthermore, it is known that fault stress changes can be induced by climate change processes and seismic triggering, interfering with the tectonic strain and impacting seismic cycle patterns, deformation rates, and even the structure’s kinematics. Altogether, these questions prompt an understanding of the occurrence of reactivation episodes and their timings. Hence, investigating the timings and possible regional mechanisms and the propensity of reactivation of seismic sources at intraplate settings is a pertinent research project. The targeted study area is Southwest Portugal, an area with quaternary deformation and younger and older structures reactivated, which is an ideal natural laboratory. The methodology developed if successful can be transferable to intraplate settings in Europe and elsewhere, investigating Quaternary activity in reactivated inherited faults with long recurrence periods. Results can be integrated into seismic hazard analysis and natural hazards management, boosting society’s resilience in a world gradually exposed to stronger and more frequent climate events, a possible mechanism for impacting regional changes in the fault stresses. SEISMO REACT will be based at the Institute Dom Luiz, University of Lisbon supervised by Prof Custódio, and a secondment in the Leibniz Institute for Applied Geophysics, supervised by Prof Tsukamoto regarding the ESR geochronology.

Keywords: paleoseismicity,fault reactivation,seismic sources,geochronology,active tectonics
Advancing the physical intelligence and performance of roBOTs towards human-like bi-manual objects MANipulation (MANiBOT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Greece,Germany,Italy,Spain,United Kingdom,Austria,Poland
Call: Pushing the limit of physical intelligence and performance (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-11-01
End date: 2027-04-30
Duration (months): 42.0
Total project cost (EUR): 6285273.75
EU funding (EUR): 6285273.75
Participants: 13
Project status: SIGNED

The MANiBOT research aims at bi-manual mobile robots, able to perform a wide variety of manipulation tasks with highly diverse objects, possibly partly or fully unknown beforehand, in a human-like manner and performance. To achieve this, we advance and fuse all necessary technologies, from multimodal perception, cognition and control, to novel cognitive mechatronics. We develop new environment understanding and object/pose recognition methods, empowered through adaptive, context-aware fusion of vision, proximity and tactile sensing and emphasizing on adequate efficiency for fast and effective manipulation, even of objects without precise model, including deformable ones, and in diverse, challenging environments with human presence. We also develop a novel suite of manipulation primitives including non-prehensile manipulations, which along with bi-manual manipulation will allow the transfer of diverse objects with various sizes, weights, shapes, materials and rigidities from a mobile robot, with performance close to that of humans, even upon significant spatial constraints. The above are fused through a novel approach for robot cognitive functions based on multi-level robot cycles that allow learning, composing and swiftly adapting robot behaviors for complex manipulations, covering key topics of sequential manipulation of multiple objects to achieve complex goals. We push the limits of physical intelligence of bimanual mobile robots by coupling our methods with novel cognitive mechatronics, fusing advanced tactile and proximity sensors with a bi-manual mobile manipulator, optimized for energy efficiency and increased autonomy, including HRI capabilities for trustworthy and efficient operation. Our outcomes will be evaluated in four use cases, in three pilot sites (TRL5), in challenging environments where the handling of abundance of different objects is needed; in retail/supermarkets and transport/airports, for shelves restocking and baggage handling operations.

Keywords: bi manual manipulation of diverse objects,adaptive multi level robot cognition and control,multi modal perception,visuotactile sensing,,efficient bimanual cobots
Watching Excitons in Photoactive Organic Frameworks (WEPOF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 2
Project status: SIGNED

One of the most urgent challenges our society is facing nowadays is the development of an energy economy based on renewable resources. A fascinating approach is artificial photosynthesis, where solar energy is exploited to produce chemical fuels out of carbon dioxide, water, and sunlight. While recent technological advances are bringing us closer to the goal of developing efficient light-harvesting platforms, a fundamental gap about the atomic-scale mechanisms remains to be filled. Understanding the atomistic details of the processes involved is of tremendous importance to drive a rational design of photoactive materials. Relevant questions include: how do electrical charges move upon light absorption? How does the atomic structure influence the ability to harvest light? Why do some materials work better than others? Answering to questions as these represents an extraordinary demanding task, since excitons, the most fundamental light-induced excitations, composed of bound electron-hole pairs, are only transient short-lived entities occurring in complex materials. The WEPOF project aims at enabling the direct experimental observation of excitons in photoactive covalent organic frameworks, providing a fundamental understanding of photoexcited states in energy materials. While the structural complexity of organic frameworks will be tackled by individuating elementary functional units, allowing rationalizing their structure-function relations, the development of unique scanning probe microscopy methods will enable to watch excitons on their relevant length- and timescales. The understanding of excitonic processes will allow steering the design of photoactive materials with improved energy conversion efficiency, providing a conceptual framework for next-generation material platforms for artificial photosynthesis.