Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cerabyte - a ceramic data storage system for global IT & cloud service provider (Cerabyte)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Our digital society generates enormous amounts of data at an ever growing speed. Most of these data are cold, which means they never change and are rarely retrieved. Storing these data consumes a lot of energy and requires hardware replacement every 3-5 years. Therefore, we have developed cerabyte, a novel cold data storage technology, which stores data on ceramic nanolayers enabling an unlimited timespan. Cerabyte outperforms these mature technologies by leveraging ceramic nano-layers in combination with a massive parallel laser writing and reading mechanism. Once data are written, no energy is needed to maintain the data for a long lifespan, which leads to savings of up to 99% of energy and CO2 emissions, as well as 95% of total cost of ownership (TCO). Cerabyte will offer data storage systems which are fully compliant with current data center standards and easy to integrate for business customers into their data storage architecture. This will disrupt the data storage component market with a market size of €41.6 bn in 2022 growing to €136.9 bn in 2030. Cerabyte has established a new value chain together with international manufacturing partners and reached TRL6 with the launch of a fully functional demo-system in October 2023 located in Aachen, Germany. The demo system has been recently validated by the US National Academy of Sciences, Engineering and Medicine Rapid Expert Consultation on Archival Data Storage Technologies for the Intelligence Community in January 2024. Our base patent for ceramic data carriers was granted in record time in EU, USA, RUS, AUS, CAN, PRC, TW, SK, JP and IN covering 77% global GDP – 67,5% smartphone & 49% global population. By combining our extensively patented technology with already existing robotic storage systems we will be able to disrupt the €50 bn data storage infrastructure market.

Keywords: data storage,ceramic data storage
A new solution in the field of chronic wounds. (Project Florence)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 6000000.0
Participants: 1
Project status: SIGNED

There is currently no straightforward proven product to heal diabetic chronic wounds. Purna has developed a new therapeutic wound healing gel, based on a new Mode of Action, which will substitute current ineffective symptomatic wound care products to cure these wounds. The wound healing gel uses the straightforward gelation of a natural compound where the gelation agent itself also acts as an active component that directly inhibits a protein (HMGB1) identified by the Flemish Institute for Biotech (Vlaams Instituut voor Biotechnologie - VIB) as a key element of an important pathway in wound healing inhibition. Its gelling capacity coupled with anti-inflammatory and anti-microbial/anti-biofilm activity is a unique asset in wound healing and will be able to transform the wound healing market. Following the successful completion of our research in particular with the demonstration of improved wound healing in diabetic pigs compared to the current standard of care and the development of our knowledge regarding the characterization and formulation of the product and mapping its antimicrobial properties , we have the essential for upscaling and to bring this novel therapy into clinical follow-up studies. The investment sought in this application is needed to help this innovation to the next phase and with this support we will be able to bridge the critical gap to ensure this development will reach the market.

Keywords: novel therapy to heal diabetic wounds with innovative formulation and mode of action
Redefining social artificial intelligence to foster more informed, thoughtful, and human-centric decision-making to address society’s challenges (ARES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Slovakia
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

In our globally interconnected world, individual events can trigger widespread ripple effects that are difficult to predict. This is especially true of events driven by human behaviour. CulturePulse is a Slovak AI startup that operates at the forefront of AI and human behaviour analysis. Built on over a decade of R&D from Oxford and Boston Universities, CulturePulse introduces ARES, a revolutionary multi-agent AI platform for risk forecasting that transforms how societal dynamics are understood, analysed, and predicted. CulturePulse pioneered a social digital twin approach - psychologically realistic AI simulations replicating complex social dynamics and behaviour patterns - leveraging a unique architecture combining natural language processing, multi-agent AI technology, and cognitive science frameworks. The platform is built on the proprietary ARES AI. The system requires no retraining and supports 93 psychological dimensions and 200 languages. It enables near-real-time event forecasting while capturing the psychological drivers of public sentiment and collective actions. Its prediction accuracy is up to 300% higher than state-of-the-art models. Our solution is poised to disrupt a multibillion-dollar market and drive substantial societal and economic benefits by enhancing prediction accuracy and reducing losses associated with poorly informed policies and decisions. CulturePulse has successfully developed the ARES 2.0 version and has validated the approach in activities that support social cohesion, conflict resolution, policy development, and enhanced government communication strategies. The current solution stands at TRL 6. The EIC grant will be strategically used for further R&D and validations to ensure ARES scalability. The equity part will be used to enter the market and ensure broad outreach.

Keywords: predictive analytics,digital twins,multi agent artificial intelligence,cognitive science,psychologically realistic digital simulations,social simulation platform,behaviour and event prediction
Beyond current AI: An explainable and efficient language architecture based on human-like Artificial General Intelligence (AGI) (Mindkind)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Artificial intelligence (AI) is considered the Steam Machine of the 4th industrial revolution, estimated to boost the global economy by $16 trillion by 2030. However, the technological, economic and social drawbacks of current Narrow AI (ANI), hamper its full development and implementation. THE MINDKIND, based on the Emotional Theory of Rationality (ETR), postulated by its founders (Mario Garcés and Lucila Finkel) has developed a new Algorithmic based General AI (AAGI) that is traceable and explainable, moving AI beyond the predictive nature of current models to a knowledgeable system, more transparent and trustworthy. It does not require big data, being more energy efficient than current AIs, and it will be able to extrapolate data from different contexts to solve new problems for which it has not been previously trained. As a result of THE MINDKIND’s AAGI approach, ETR technology will emulate a pseudo-consciousness system capable of displaying emotions, reasoning, decision-making, and human-like behavior. This capability will enable machines to perform critical tasks. Consequently, capacities such as Movement, Behaviour, Tool management and Natural Language, will organically emerge from the dynamics of the ETR cognitive architecture, addressing the four major issues of current limited Generative models and ANI.

Keywords: artificial general intelligence,natural language,video games,traceability,explainability,knowledge generalization,efficiency,energy saving
Analytical approaches for the assessment of human exposure to polyhalogenated alkanes (PXAs) (ANEX-PXA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

Chlorinated paraffins (CPs) are polychlorinated linear chain alkanes with high production volumes used as flame retardants and plasticizers in a wide array of consumer goods. CPs may be released from treated goods and have become widely distributed in the environment and human tissues. Humans are exposed to CPs via contaminated indoor dust and food, while certain CPs have been registered as United Nations Persistent Organic Pollutants (POPs) and their usage restricted due to well documented toxic and bioaccumulative properties. Recent evidence has suggested that banned CPs may have been replaced by compounds known as polyhalogenated alkanes (PXAs), which share very similar chemical structures to CPs, differing only by the addition of bromine atoms. Both CPs and PXAs comprise of mixtures of thousands of isomers, making analysis and quantification highly complicated. A recent pilot study of PXAs in indoor dust revealed that the replacement compounds may be present at similar levels as banned CP groups. Based on the physicochemical similarities, PXAs are predicted to share similar bioaccumulative and toxic properties as banned CPs, but have not been studied widely. This research projects aims to develop the first analytical procedures for quantification of PXAs in indoor dust and generate methods for assessing the occurance of PXAs in a variety of environmental matrices. Measurements in indoor dust samples from Europe and the United States of America will be used to conduct a world-first human exposure assessment for PXAs. Developed methods will then be applied for retrospective screening of PXAs in archived data files to provide a broad snapshot of PXA contamination in food and the environment for the first time. The outcomes of this project are intended to characterize the current contamination status of PXAs in indoor dust, food and the environement with the objective of public health protection against potentially hazardous chemicals.

Keywords: human exposure assessment,environmental contamination
Scale-resolving Simulations ​for Innovations in Turbomachinery Design (Sci-Fi-Turbo)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Italy,France,Sweden,Australia,United Kingdom
Call: Competitiveness and digital transformation in aviation – advancing further capabilities, digital approach to design (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 3436753.75
EU funding (EUR): 3436753.75
Participants: 11
Project status: SIGNED

Sci-Fi-Turbo aims to revolutionise the aero engine design process by advancing and integrating high-order scale-resolving simulations (SRS) and optimization methodologies into standard industrial workflows. SRS are a key enabler for developing ultra-efficient propulsion systems that drastically reduce GHG emissions by 2035 and achieve the EU's target to be climate-neutral by 2050. The advancements will boost design process capabilities and reduce product development cycles. Future engine concepts require opening up the design space and solving complex design problems out of reach for today's standard industrial design processes within the required timeframe. To achieve the necessary step change in engine design, a similar step change is needed for the design approach. Sci-Fi-Turbo fills this urgent need by exploiting opportunities in three foundation technologies: High-performance computing, high-order numerical methods, and AI/ML. The combination is used to implement and demonstrate two key advancements. First, a highly integrated high-order SRS design process is established for modern CPU/GPU hardware, meeting robustness, accuracy, and turnaround time requirements. It will provide increased functionality and effectivity at an industrial level and pave the way for the uptake of SRS-based design by the industry. The high accuracy of the methodology will also reduce the need for low-TRL testing and enable new concepts and extended operating conditions. Second, an SRS-assisted multi-fidelity, data-driven optimisation framework is developed, which embeds and exploits the advantages of highly accurate high-order SRS while leveraging AI/ML methods to increase the predictive capability of lower-fidelity simulations and maximize overall process accuracy and speed. Dedicated experiments support the technology advancement and will enable the design of net-zero-emission engines in due time and contribute to the digital transformation of the aviation industry.

Keywords: scale resolving simulations,machine learning,data driven turbulence modelling,multi fidelity optimization,turbomachinery design,climate neutral aviation
Empowering Minds: Boosting Research in Citizen Engagement and Schools (EU-EMBRACES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Portugal
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-05-01
End date: 2025-12-31
Duration (months): 20.0
Total project cost (EUR): 297365.0
EU funding (EUR): 297365.0
Participants: 3
Project status: SIGNED

Innovation makes Europe one of the most socially inclusive and developed regions of the world. A significant public policy effort was put in place to foster science, technology and innovation, while contributing to solve societal challenges. The main purpose is to unleash innovation-led growth that also contributes to reinforce societal values and sustained development. Engaging society with science and innovation has reached a new paradigm with the Horizon Europe Missions. All sectors need to be actively involved in implementing the Missions to reach the expected goals. From schools to companies, from scientific associations to NGOs, all will be called to contribute by co-creating new solutions, products and processes. The new generations are of particular importance. The innovators of 2030 are now being nurtured in schools, supported by science centres, museums and other non-formal education stakeholders. However, many still feel that those spaces are not meant for them. In fact, “participants for these science communication activities are drawn from socially dominant groups. We can also infer (…) who is less likely to participate in science communication: people from socio-economically disadvantaged backgrounds and ethnic minorities” (Dawson, 2021). EU-EMBRACES will address this challenge, by engaging those communities while showing how the HE Missions can positively impact their lives. EU-EMBRACES will be developed by a consortium led by ITQB NOVA, a research and academic institution with extensive experience in outreach and event organization, in partnership with Ciência Viva, a national agency dedicated to Scientific Culture; and i3S, a research centre with a solid educational programme for schools and the public. The project will bring together researchers and other stakeholders involved in the HE Missions and the public, in more than 250 activities in 10 venues across the country, with the support of research institutions and local authorities.

Keywords: inclusion science outreach education life long learning schools researchers
Solidarity, Sovereignty, and Sanctuary on the Seas: A Global History of Boat Refugees since the 1940s (SOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In 2015, over one million boat refugees sailed across the Mediterranean. This was not the first time that people took to the seas in search of asylum. During the 1940s, Jewish boat refugees voyaged across the Mediterranean; in the 1970s and 1980s, Vietnamese boat people traversed the South China Sea; in the 198In 2015, over one million boat refugees sailed across the Mediterranean. This was not the first time that people took to the seas in search of asylum. During the 1940s, Jewish boat refugees voyaged across the Mediterranean; in the 1970s and 1980s, Vietnamese boat people traversed the South China Sea; in the 1980s and 1990s, Cubans and Haitians tried to navigate the Caribbean to reach the US; and in the 1990s and 2000s, boat refugees sailed across the Indian Ocean, the Gulf of Aden and the Mediterranean in an attempt to reach Australia, Yemen, and Europe respectively. The central research question framing this project is: how did notions of solidarity, sovereignty and sanctuary influence the experience and reception of boat refugees across time and space? The research team will be guided by the related sub-question: who hindered and who helped boat refugees on their journeys, and why? Each of the sub-projects will examine a) whether there was solidarity onboard between boat refugees, b) whether boat refugees encountered solidarity from non-state actors, such as merchant vessels, fishing boats and NGO search and rescue missions, c) how states responded to boat refugees at sea, and d) whether boat refugees attained sanctuary after their journey. This project’s ground-breaking character lies in three aspects: 1) thinking through seas, 2) going beyond the state, and 3) comparing the experience and reception of boat refugees across time and space. The main sources that the project will rely upon will be interviews with boat refugees, non-state and state actors, oral history, state archives, NGO archival collections, legal cases, and contemporary media coverage.

Keywords: boat refugees refugee policies refugee journeys migration history
ExeVir's XVR011, a best in class nanobody-based biology that broadly neutralizes SARS-COV-1 and SARS-COV-2 (XVR011 Phase 2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,France
Call: Vaccines & therapeutic clinical trials to boost COVID-19 prevention and treatment (HORIZON-HLTH-2021-CORONA-01, 2021)
Start date: 2021-12-01
End date: 2022-11-30
Duration (months): 12.0
Total project cost (EUR): 9902750.0
EU funding (EUR): 9902750.0
Participants: 4
Project status: CLOSED

XVR011, ExeVir's clinical lead candidate has emerged from scientific research from labs of highly regarded virologist Xavier Saelens and biochemist Nico Callewaert. Nonclinical data has recently been published in Cell and a preprint on BiorxIV. XVR011 is a nanobody-Fc fusion, has best-in-class potential, neutralizes SARS-CoV-2 and minimizes the development of lung damage in hamsters. The lama-derived single-domain antibodies are smaller than human antibodies and can attach to parts of a virus that are difficult to access for the human immune system. XVR011 inactivates spike proteins and sterically blocks spike binding to ACE2, preventing virus from entering a human cell, stopping viral replication; this supplements the patient's own immune response in a critical time window during which many COVID-19 patient's immune system reacts too slowly, giving it more time to do its job and eliminate the virus. It binds to a unique highly conserved epitope in the viral receptor-binding domain. Its epitope is much less susceptible to human antibody immunity pressure that can lead to viral escape, resulting in retained potency against such escape variants. It thus neutralises the rapidly spreading SARS-CoV-2 variants, and exhibits a unique, wide scope binding across the Sarbecovirus clades. Furthermore, XVR011 has been optimized for stability, safety and manufacturability. XVR011 received approval from the Belgium regulators to move into its Phase 1b. Seven IP patents were filed early on during the pandemic. ExeVir has surrounded itself with both a team of experienced entrepreneurs and is backed by a mix of private and public experienced partners and has a strong board of directors bringing with expertise across the whole value chain. The objectives of this proposal is to demonstrate XVR011 safety and efficacy in a global Phase 2; to strengthen its nonclinical package including neutralising variants data, set-up its manufacturing process and progress its regulatory pathway.

Keywords: sars nanobody covid 19