Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-throughput 4D imaging for nanoscale cellular studies (NANO4LIFE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Austria
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1778325.0
EU funding (EUR): 1778325.0
Participants: 1
Project status: SIGNED

Fluorescence microscopy is an invaluable tool for exploring the structure and function of biological processes. It provides high specificity and contrast for the observation of cellular components tagged with fluorescent molecules in a minimally invasive fashion, allowing the study of live specimens. Furthermore, the development of super resolution (SR) fluorescence microscopy has unlocked the access to spatial resolutions beyond the diffraction limit of visible light (~250nm), fuelling the discovery of new biological structures and dynamics. Nevertheless, achieving resolutions below ~10nm is challenged by multiple trade-offs between spatial and temporal resolutions, depth of observation and photo toxicity, making it difficult or impossible to obtain a molecular resolution. Additionally, axial resolutions are inevitably poorer than lateral ones, unless utilizing a complex multi-objective lens approach. I recently developed MINFLUX, a localization technique that merges concepts of SR with information theory. It achieves isotropic nanometer resolution in three dimensions with a single objective lens and has unrivaled spatio temporal resolution. However, a platform that enables these capabilities in a high-throughput manner for entire cells and tissue has not yet been developed. I aim to fill this technological gap; with my background and experience, I am in a unique position to assure the success of this project and establish these technologies in the scientific community. The performance of fluorescence imaging and tracking will progress orders of magnitude in the years to come, signaling yet another revolution for optical nanoscopy.

Keywords: super resolution microscopy,single molecule tracking,high throughput parallelization
Understanding institutional change in Asia: a comparative perspective with Europe (INCAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,France,United Kingdom,Japan
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 778500.0
EU funding (EUR): 778500.0
Participants: 5
Project status: CLOSED

The project INCAS aims at creating a top-level research and advanced training network on institutional change in Asia, in comparative perspective with Europe. The coordinator, Ecole des Hautes Etudes en Sciences Sociales (France), promotes this network together with Oxford University, Freie Universität Berlin, in collaboration with Waseda University (Japan). The partners have chosen Japan as a reference point because of its comparability with Europe as shown by previous studies, its historical influence on development and further institutional changes in Asia, and the expertise accumulated within our research team. Our approach, which refers to the literature on comparative capitalism, is fundamentally interdisciplinary by nature, as it aims at gathering economists, economic historians, political economy specialists, sociologists, and lawyers, who are specialized in various fields such as finance, labor economics and sociology, Asian studies, etc. Our major aim is to propose a new theory of institutional change that better takes into account diverse dimensions that have been overlooked by previous attempts such as: the historical experience of institutional change in Asia that went hand in hand with growth and development; the relations between (especially financial) liberalization and corporate diversity; the interaction between political economy, socio-economic and legal variables. It requires not only the interdisciplinary approach described above but also an empirical investigation that mobilizes a database for corporate characteristics. Each institutional member of INCAS has developed its own research strategy on a similar object (institutional change in Asia and Europe) and the goal of this project is to organize a knowledge transfer within our team (and later outside the research team) in order to build a comprehensive research program.

Keywords: institutional change,financial systems,europe,asia,comparative capitalism,corporate governance,liberalization,internationalization,financialization
International Centre for Research on Innovative Bio-based Materials (ICRI-BioM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Poland,Poland,Poland
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 494375.0
EU funding (EUR): 494375.0
Participants: 6
Project status: CLOSED

The aim of this project is to establish a new centre of excellence in the Lodzkie Region, Poland, by creative and collaborative efforts, i.e. TEAMING with Max Planck Society (MPS), Germany, as the internationally leading institution. The planned International Centre for Research on Innovative Bio-based Materials (ICRI-BioM) will focus on design, synthesis, characterization and practical implementations/applications of advanced materials, exemplified by biomaterials, bio-products, and multifunctional smart polymer systems. This program fits into the Regional Strategy of the Lodzkie Region as one of smart specialisations, represented in the regional strategic documents, as well as the national strategy. An added value will be the synergistic effect created by combining expertise and ambitions of main research institutes in this area from Lodzkie Region and MPS. During the first year, a strategic Action Plan will be created with teaming partners and other participants: industry, research, regional and national authorities. The proposed Business Plan will describe a vision for the establishment of the ICRI-BioM: (i) long-term science and innovation strategy; (ii) organizational and management structure; (iii) a legal form of independent, autonomous non-profit institution; (iv) all required operational regulations. At the first stage of its activities, ICRI-BioM will be supported by national and regional funds, European structural and investment funds, Horizon 2020 and research, innovation and competitiveness Union - related programs. Within several years, the ICRI-BioM will become the strategic interdisciplinary research centre and it will influence the economic development of the region and country. By teaming with MPS, as the best European research institution, we trust that ICRI-BioM will be able to mimic the best research practices, adopt them into Polish reality and re-invent and re-shape the Polish research landscape.

Keywords: centre of excellence,biobased materials,biofuels,bioplastics,drug delivery systems,composites,biodegradable polymers,biopharmaceuticals
Mechanism of Enzyme Rhodopsin Activation (MERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2398750.0
EU funding (EUR): 2398750.0
Participants: 1
Project status: CLOSED

Channelrhodopsin, which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble of neuronal cells with short light flashes, a technology we now call "Optogenetics." However, though highly desirable, the inactivation of specific cells using moderate or low light intensities is not yet possible. The recently discovered rhodopsin-guanylyl-cyclase (RhGC) of the fungus Blastocladiella emersonii offers an elegant solution to this problem. Moreover, RhGC is a totally novel and uncharacterized sensory photoreceptor, and the first member of an enzyme rhodopsin family that urgently awaits in-depth characterization. Accordingly, the goal of the “mechanism of enzyme rhodopsin activation” (MERA) proposal is to obtain a comprehensive understanding of this novel photoreceptor, and to determine its functionality for broad application in optogenetics and other research fields. The MERA project is subdivided into four objectives. The first objective is the characterization and engineering of RhGC in cell lines and neurons as well as coexpression of RhGC with a cGMP-gated K+ channel to develop a "Light-Hypopolarizer" for cell inactivation. The second objective is to understand the dynamics of RhGC using a variety of biophysical technologies including time resolved UV-vis, FTIR, and Raman and EPR spectroscopy. A third objective is the generation of crystals for X-ray crystallography and the development of a three dimensional RhGC model. The fourth and final objective is the computer-aided conversion of RhGC into a rhodopsin-phosphodiesterase (RhPDE) for down-regulation of the second messenger cGMP and/or cAMP using light. The ultimate outcome will be a detailed understanding of a novel class of sensory photoreceptors with new perspectives for broad optogenetic applications.

Keywords: optogenetics,light activated enzymes,infrared spectroscopy
Long-term testing of airtightness to increase energy efficiency in buildings. (LTT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2021-07-31
Duration (months): 36.0
Total project cost (EUR): 2452800.0
EU funding (EUR): 1716960.0
Participants: 2
Project status: CLOSED

The LTT Phase 2 project is designed to address and implement the findings of our Feasibility Study and to enable a rapid and successful commercialisation of our Long-term testing of airtightness (LTT) technology. Venturigo has developed the only solution in the market capable of monitoring 24/7 how much air, energy and money are leaking in a given building, and to adjust the ventilation system to reduce this leakage by an average of 50%. LTT has x100 lower upfront cost than alternative solutions in the market for improving airtightness, and a 5.8/6.9 months payback period in high-rise residential buildings and large services buildings, respectively, a major advancement over the current state-of-the-art and our unique selling point (USP). The EC Nearly Zero-Energy Building Strategy 2020 highlights the importance of a sustainable European economy and society based on the efficient use of resources and renewable energy. In this sense, while buildings are now responsible for 40% of energy consumption and 36% of CO2 emissions in the EU, the Energy Performance of Buildings Directive requires all new buildings to be nearly zero-energy by the end of 2020 and all new public buildings by 2018. LTT will help to face these challenges by reducing buildings CO2 emissions by 690,296 tonnes and will offer our clients accumulated energy and cost savings of 1,237 MWh and €203.2m, respectively during the first 5 years of commercialisation according to our 5-years projections. LTT addresses the large and growing market of technologies for improving energy-efficiency in buildings, which is projected to increase from €163.4bn in 2017 to €259.1bn in 2026 attaining a compound annual growth rate (CAGR) of 5.26%. By successfully implementing the LTT project, we expect to create a measurable impact on Venturigo quantified as increased accumulated revenue of €58.3m and profit of €27.0m, creating 29 full time employments in our company and 55 indirect jobs in Europe.

Keywords: buildings energy efficiency,building envelope,nearly zero energy buildings,airtightness,insulation,stack venturi effect,mechanical ventilation,hvac,co2 emissions,low carbon,machine learning
Intelligent management system for integrated multi-trophic aquaculture (IMPAQT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Italy,Spain,Ireland,Türkiye,Greece,Greece,Türkiye,Poland,China,France,France,Netherlands,Netherlands,United Kingdom,Luxembourg,United Kingdom,United Kingdom,Portugal
Call: Promoting and supporting the eco-intensification of aquaculture production systems: inland (including fresh water), coastal zone, and offshore (H2020-SFS-2017-2, 2017)
Start date: 2018-05-01
End date: 2021-08-31
Duration (months): 40.0
Total project cost (EUR): 6218180.0
EU funding (EUR): 5883180.0
Participants: 22
Project status: CLOSED

The Integrated Multi-Trophic Aquaculture (IMTA) is acknowledged as a promising solution for the sustainable development of aquaculture. However, IMTA has been only tested at very small scale in Europe, while management of large-scale IMTA areas remains difficult. The high level ambition of Impaqt project is to drive a paradigm shift in the EU Industry and its , paving the way to both a more environmentally friendly and more efficient/higher yielding European Industry. To that respect, Impaqt proposes an intelligent management platform for IMTA. Impaqt will develop and deploy novel sensors and data sources, together with smart systems required for long term autonomous monitoring in the field. An advanced IMTA model will be provided which yields spatially explicit information on how the different farm components interact with the environment on the scale of an ecosystem and that can be used for planning decisions by both farmers and regulators. Last but not least, an integrated management system, operating at the scale of an IMTA farm and comprising analytics and decision support functionalities, will be developed to enable enhanced operational decisions for animal welfare, production optimization, environmental protection and food quality assessment. Impaqt systems and models will be validated in 6 pilots (Scotland, The Netherlands, Ireland, Turkey and China), addressing inland, coastal and offshore aquaculture. Impaqt will demonstrate the eco-intensification of EU aquaculture, by demonstrating the eco-efficiency and the environmental impacts minimized, the socioeconomic benefits and ecosystem services enabled, as well as the transition towards a circular economy business model. Impaqt brings together a considerable range of partners including 14 academic/research organizations, 4 SMEs and 3 large industries, all leaders in their respective fields/business, while aims to effectively transfer the project’s results to relevant stakeholders through training activities.

Keywords: integrated multi trophic aquaculture imta concept,multi purpose,multi sensing and multi functional monitoring system,imta management system,semantic aquaculture,fish and seafood quality
POINT OF CARE DEVICE FOR VITAMIN D DEFICIENCY MONITORING (OSAvit-D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-10-15
End date: 2020-10-14
Duration (months): 12.0
Total project cost (EUR): 100687.5
EU funding (EUR): 100687.5
Participants: 1
Project status: CLOSED

OSASEN is a young technological SME focused on the development of novel biosensors for healthcare (Point of Care-PoC devices), addressing priority needs in healthcare diagnostics and/or therapies monitoring for the benefit of patients, providing affordable systems with unique features that meet specific well identified requirements in healthcare. OSASEN has recently identified a healthcare need in relation with prevention, treatment and monitoring of Vitamin D (VitD) deficiency. VitD (1,25-DihydroxyvitaminD) is considered a multipurpose steroid hormone that in human plays an essential role in multiple aspects, being its primary role to participate in the regulation of metabolism of calcium and phosphorous. VitD deficiency is evident throughout the European population at a prevalence of 13% (FP7-613977-ODIN project), a rate that is a matter of concern. People over 50 have an increased risk of vitamin D deficiency with consequent bone loss risk leading to osteoporosis and fractures. Emerging evidence has shown that VitD administration improves muscle performance and reduces falls in VitD deficient older adults. Other populations of higher risk for VitD deficiency are children, pregnant and lactating women and patients with digestive disorders, among others. VitD deficiency is also associated with increased risk of cancer, cardiovascular disease, infections, and autoimmune diseases. For example, several studies have shown that VitD levels are lower in Multiple Sclerosis patients, and monitoring and VitD supplementation to them is highly recommended. In this context, OSASEN has identified the opportunity to develop a novel PoC device for the quantification of VitD in blood or urine based on lateral flow (LF) immunoassay, combined with electrochemical detection on screen printed electrodes (SPEs). For doing so, it is necessary to incorporate an expert in LF immunoassays and antibody selection, conjugation, handling & stabilization to OSASEN’s team.

Keywords: biosensors,healthcare,point of care,lateral flow immunoassays,quantitative results,diagnosis,monitoring,vitamin d,electrochemical detection,screenprinted electrodes,antibodies,biological fluids
Medieval Hydrotechnology: an interdisciplinary case-study of water management in the historical and physical landscape of Messinia, South Greece (HYDROMEDIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-12
End date: 2023-07-11
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The HYDROMEDIE project will examine a series of key issues using innovative methods from landscape archaeology. The principal challenge will be to examine the strategies used for water management in different societies of medieval and post-medieval Messinia, comparing late Roman, Byzantine, Frankish, Venetian, Ottoman and early modern techniques in a series of case-studies. Previous research has not succeeded in differentiating and dating water-related infrastructure on a large scale, and this comparative analysis requires application of innovative techniques including GIS-based HLC and spatial analysis, 3D recording and analysis of surviving structures, micromorphological analysis of mortar, and scientific dating of samples using radiocarbon AMS (atomic mass spectroscopy) and OSL (optically-stimulated luminescence). The Fellow will be trained in all these areas through one-to-one instruction, tailored training courses, on-the-job learning and secondments. The training will provide skills necessary for a successful future career in the highly interdisciplinary fields of landscape research and medieval archaeology. The project fieldwork and sampling will focus on case-studies where the natural supply of water is insufficient for basic subsistence, necessitating use of water collection and storage technologies. The subsequent interpretation will seek to identify the social and cultural implications of different strategies, including not only the economic value of water but also the ideological or even religious implications. With this in mind, the case-studies will embrace a range of landscapes, including examples with fortifications, ecclesiastical sites and agricultural settlements.

Keywords: medieval and post medieval archaeology,georchaeology,byzantine archaeology,mediterranean greece,water management,hydrotechnology
COMbination of non-contact, high speed monitoring and non-destructive techniques applicable to LASER Based Manufacturing through a self-learning system (COMBILASER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Austria,Germany,Spain,Slovenia,Slovenia,Finland,France,United Kingdom
Call: Process optimisation of manufacturing assets (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3439420.0
EU funding (EUR): 3439420.0
Participants: 13
Project status: CLOSED

The continuous growth of laser-based manufacturing processes has allowed the introduction of many new applications in different industries during last years. This advance has brought many advantages in terms of parts complexity, required resources (human and material) or environmental impact. On the other side, parts manufacturing through laser based processes require specific designs/adjustments for each one of the applications (this delays considerably the time-to-market of new products). This means that a more holistic approach will be desirable in the following years in order to meet rapidly-changing market requirements. In addition to this fact, productivity will always be a great concern for European companies. The aspects that restrict process productivity are linked to non-productive intervals, such as scrap generation, defective parts manufacturing or pores/cracks appearance that make parts useless. In this environment, the use of easily controllable manufacturing processes is mandatory in order to increase process productivity and reduce the time-to-market while keeping or increasing final quality of manufactured products. Laser processes have the main advantage of being controllable processes, additionally to being fast and accurate processes, allowing precise actuation over the equipment parameters that directly can be translated in a change of the physical parameters, those that affect to the final quality of manufactured parts. Both laser welding and cladding rely on the same physical process of material melting. Therefore, all of them have common problems. In order to overcome undesirable situations, new strategies need to be developed which will be based on two different main branches, all of them under zero defects manufacturing philosophy: 1) Monitoring, and 2) NDT solutions. The objective of COMBILASER is the combination of these two worlds through a self-learning system.

Keywords: self learning,monitoring,non destructive testing,non contact,laser beam welding,laser cladding