Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards MXenes’ biomedical applications by high-dimensional immune MAPping (MX-MAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Latvia,Ukraine,Türkiye,Ireland,Serbia,Germany,United States,Saudi Arabia,Canada,United Arab Emirates
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 1523257.14
EU funding (EUR): 1389200.0
Participants: 16
Project status: SIGNED

The long-term goal of MX-MAP is to develop a functional pipeline for the immune characterization of new 2D nanomaterials of MXene family, for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applications. The immune characterization of the tested materials on the basis of intrinsic physical-chemical and immunological properties, through the combination of the most innovative technologies such as single-cell mass cytometry (CyTOF), will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, scaffolds for tissue engineering, cancer therapy, and antibacterial agents. MX-MAP will develop key chemistry and immune-based strategies for MXene medical applications. The implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2D materials and their use in biomedicine. The MX-MAP project involves fourteen key players in European and non-European countries, including the United States, Canada, Saudi Arabia, and three partners from Ukraine, coming from academia and SMEs. This program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of Science. Chemistry, biology, immunology, engineering, and cancer research are the expertise of MX-MAP. The senior team members are among the most influential scientists, including Prof. Yury Gogotsi (H-index=168) - inventor of MXenes, Prof. Klaus Ley (H-index=147) - one of the most cited immunologists worldwide, and Prof. Husam N Alshareef (H-index=99). The Consortium is perfectly balanced in terms of equal gender presence; the project Coordinator Lucia Gemma Delogu is a female, and 2 out 4 of four WP leaders are female. The project embraces a large view of inclusiveness and diversity, including countries with smaller economies such as Ukraine.

Keywords: mxenes,nanomedicine,2d materials,immunity,cancer therapy,tissue engineering,antibacterial properties
Strongly Enhanced Sensitivity EPR through Bimodal Resonators and Quantum-Limited Amplifiers (Strong-ESPRESSO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Lithuania
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2499919.0
EU funding (EUR): 2499919.0
Participants: 1
Project status: SIGNED

Electron paramagnetic resonance (EPR) is a powerful tool employed across various disciplines including structural biology, chemistry, physics, material science, and many others. It provides important and unique information on a local electron spin environment, electronic properties and dynamics of various paramagnetic centers. However, a relatively low sensitivity of this method often limits the range and type of systems that can be studied. Thus, major advancements in EPR sensitivity are crucial to significantly broaden its applicability, encompassing new and highly relevant systems such as single cells. The Strongly Enhanced Sensitivity EPR through Bimodal Resonators and Quantum-Limited Amplifiers (Strong-ESPRESSO) project will ignite a revolution in EPR by employing sophisticated bimodal microwave resonators and intricate ways of noise reduction in tandem with novel microwave amplifiers developed for quantum technologies. We will achieve this by first delivering a new generation of EPR cryoprobeheads, which will utilize the orthogonal-field bimodal cavities, allowing to reach the sensitivity limit of these instruments. Secondly, we will transfer the bimodal cavity concept to planar superconducting microresonators, enabling the employment of these tools to study tiny (pL volume) samples of typical fast-decohering spin systems (e.g. protein droplets). Finally, we will develop an ultra-sensitive EPR setup based on the radiative cooling effect of the bimodal resonators and recent advances in the quantum-limited microwave amplifiers. This revolutionary new setup is expected to provide a ground-breaking 5000x reduction in the EPR measurement time, simultaneously preserving compatibility with ordinary EPR experiments and samples. Throughout the project, we will immediately apply the developed tools to study new and intricate spin systems in the fields of catalysis, protein droplets, and single cells, leading to major impacts far beyond EPR.

Keywords: electron paramagnetic resonance cryoprobehead microresonator quantum limited amplifier sensitivity spin labels protein droplets catalysis single cell
Dissecting Microglia vulnerability to STress response in Multiple Sclerosis through human iPSC modelling (MiST-MS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Shifting from the traditional focus on central nervous system-targeting lymphocytes, MiST-MS posits that glial responses, particularly cellular senescence, are required to compartmentalized self-sustaining chronic inflammation in multiple sclerosis (MS) and related long-term clinical outcomes, including disability. MiST-MS is specifically designed to address the urgent need to identify new therapeutic targets to halt MS clinical progression through two interconnected research lines. The project will first identify cell-specific perturbations and molecular pathways associated with inflammation-driven early brain aging using MS human iPSC-derived microglia and genome-wide CRISPR-Cas9 screenings. By employing cutting-edge computational methodologies (single-cell CRISPR-seq, multi-omics integration, composite assessment, and cellular networking/signaling), MiST-MS offers a unique opportunity to identify and dissect mechanisms underlying microglia resilience versus vulnerability and their impact on stress responses, both independently and within the context of hiPSC-derived inflamed glia-enriched brain organoids. MiST-MS represents a ground-breaking modeling pipeline to study inflammation-driven early brain aging in MS. At the patient-level, since MS patients with evidence of smoldering inflammation (marked by the presence of chronic active lesions by in vivo MRI) exhibit poor tissue repair capacity and worse clinical outcomes, the project will also aim to identify common and divergent glial and neuronal responses between MS patients with and without chronic active lesions generating human iPSC lines for personalized medicine applications. In summary, MiST-MS is a highly innovative interdisciplinary project that provides an unprecedented understanding of microglia states in response to injury and streamlines the rational design of future therapies to mitigate chronic inflammation-driven premature brain aging and halt MS clinical progression.
The romanization of Europe and its impact on Iron Age horse breeding and ritual practices: a DNA assessment in Gaul (GaRlic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

Horses represent one of the animal species that most impacted human history. They armed past societies with fast mobility while they provided new farming companions and crucial allies at war. As one of the most prominent symbols of wealth and prestige, horses were also commonly integrated in a variety of belief systems. This was the case for protohistoric Gaul from 500 BCE, where horses became increasingly associated with ritual practices, ranging from simple isolated deposits, to funerary rituals in connection with humans and chariots, and sacrificial sanctuaries. Current understanding of these horse-centered practices, and how they were transformed under Roman influence from the 1st century CE is, however, extremely limited for the lack of relevant textual historical sources. The GaRlic project proposes to combine state-of-the-art methodologies at the forefront of biomolecular archaeology to gain fine-grained resolution into ritual and breeding practices in protohistoric Gaulish horses, and follow their changes during the Romanisation process. Our core hypotheses are that specific animal types were bred across Gaul and selected for ritual practices, and that non-local horse resources were increasingly integrated during the Roman Period, ultimately reshaping both breeding and ritual practices. GaRlic builds on the availability of an exceptional archeological collection of protohistoric and Roman horse assemblages in Gaul and involves internationally recognised experts in zooarchaeology, ancient DNA and statistical genomics. It will investigate, for the first time, the horse bloodlines and the embodiment of social norms underlying Gaulish ritual practices and will reveal how the rise of the Roman Empire transformed such practices and, more generally, the pre-existing Iron Age horse agrobiodiversity.

Keywords: ancient dna,horse,genomics,gaul,romanisation,rituals,agrodiversity
Catalytic HTL Coupled to MIcrowave pretreatment for low Nitrogen microalgal biocrude (CatHyMiNi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-20
End date: 2027-01-19
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

The transport industry is going through a revolutionary moment in its quest to reduce its carbon footprint, with biofuels being one of the viable options. High productivity, lipid content and its ability to capture CO2 make microalgae a competitive biomass. New technologies such as hydrothermal liquefaction (HTL) has recently attracted the attention in research as it avoids the energy-costly drying step and produces bio-oil at mild temperatures. Nonetheless, conventional HTL process suffers from bio-crudes high nitrogen content, mainly caused by protein content. Furthermore, the biocrude’s high oxygen content reduces its calorific value making biocrude unattractive in addition to its high NOx emissions during combustion. Since nitrogen and oxygen in biocrude respond differently to processing temperature, an approach that would favor simultaneous reduction of both would be revolutionary. The nitrogen removal before the main HTL process could be the solution. In this perspective, the combination of microwave pretreatment and HTL process can be promising. However, this non-selective method may compromise bio-oil yield. In MicroWCatHydroN, we investigate nitrogen-selective catalysts to specifically target nitrogen compounds and maintain the trade-off between desired bio-oil yield and properties. The catalytic activity of nickel can promote hydroisomerization and deoxygenation reactions, thereby improving bio-oil’s cold flow properties and heating value. Overall, this green chemistry-compatible route is economically and technically feasible. Industrial scale-up of algae conversion requires a complete characterization of its complex degradation mechanisms and phenomena occurring during the process in order to understand how nitrogen compounds are formed and consumed. In this sense, MicroWCatHydroN aims to develop a new chemical kinetic model for ParaChlorella kessleri liquefaction. In conclusion, research is expected to increase the production of high-quality bio-oil.

Keywords: hydrothermal liquefaction,microwave,kinetic modelling,denitrification,saf,microalgae
ICT Standardisation Observatory and Support Facility in Europe (StandICT.eu 2029)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Belgium,Spain,Germany
Call: Facilitate the engagement in global ICT standardisation development (CSA) (HORIZON-CL4-2024-HUMAN-03, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 8187095.62
EU funding (EUR): 6000000.0
Participants: 7
Project status: SIGNED

StandICT.eu 2029 builds on the success of the previous three editions [2023-26, 2020-23, & 2018-19], delivered by the original partners who designed the previous editions, considered in Europe as the “go-to project” on ICT Standards in Europe. Its principal goal is to strengthen its global reach in the EU ICT Standardisation Ecosystem, by: a) managing a neutral and efficient facility supporting a Fellowship Programme with € 4.2M funding in 36 months & 6 Open Calls; b) delivering ICT standardisation landscape & gap analysis via Technical Working Groups, empowering contributions from ICT standardisation experts. Timely standards updated in the EUOS EU Observatory for ICT Standardisation; c) delivering a mentoring & coaching programme for the next generation of ICT standardisation experts, SMEs & researchers with SDOs, EU & national funded R&I projects & engage directly with a subcontract signed with the ESOs: ETSI & CEN & CENELEC; d) Providing a forum for foresight analysis to guarantee high-level steering with an authoritative Foresight Committee Board FCB supported by funded fellows active in SDOs, early-warning signals in-synch with the MSP, ICT Rolling Plan & High-level Standardisation Forum; e) Organising and support standardisation meetings of SDOs, global fora & consortia so Europeans, and SMEs, may participate easily. Consortium: Trust-IT Services (IT, coordinator), COMMpla (IT), Dublin City University (IE), Open Forum Europe (BE), AUSTRALO (ES), Digital SME Alliance (BE), Fraunhofer Institute for Systems & Innovation Research ISI (DE). Outputs: Fellowship Programme, 1200+ proposals, 300+ European Experts Funded & 70+ External Evaluators; 4,000+ metadata of ICT Standards in the Observatory; 20+ Webinars, 3 Mentorship Events, Training Lectures, 2 Impact Events & Reports, Policy recommendations, 8 TWGs, 25+ MoUs, 1000+ participants in webinars. Sustainability strategy and an engaged, well represented multi-stakeholder ICT Standardisation Community.

Keywords: standardisation ict sdos european standardisation experts fstp
Fuselage, Rear Fuselage and Empennage with Cabin and Cargo Architecture Solution validation and Technologies for H2 integration (FASTER-H2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Germany,Spain,Czechia,France,Netherlands,Italy,Belgium,Denmark,Greece
Call: Advanced Low Weight Integrated Fuselage and Empennage for Short Range and Short-Medium Range Aircraft (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 27405779.23
EU funding (EUR): 23322380.0
Participants: 36
Project status: SIGNED

The FASTER-H2 project will validate, down select, mature and demonstrate key technologies and provide the architectural integration of an ultra-efficient and hydrogen enabled integrated airframe for targeted ultra-efficient Short/Medium Range aircraft (SMR), i.e. 150-250 PAX and 1000-2000nm range. To enable climate-neutral flight, aircraft for short and medium-range distances have to rely on ultra-efficient thermal energy-based propulsion technologies using sustainable drop-in and non-drop-in fuels. Besides propulsion, the integration aspects of the fuel tanks and distribution system as well as sustainable materials for the fuselage, empennage are essential to meet an overarching climate-neutrality of the aviation sector. Green propulsion and fuel technologies will have a major impact on the full fuselage, including the rear fuselage, the empennage structure as well as cabin and cargo architecture in so far as the integration of storage and the integration of systems for the chosen energy source are concerned (H2, direct burn, fuel cell). Not only do the specific properties of hydrogen necessitate a re-consideration of typical aircraft configurations, requiring new design principles formulation and fundamental validation exercises, but they also raise a large number of important follow-on questions relating to hydrogen distribution under realistic operational constraints and safety aspects. The project will explore and exploit advanced production technologies for the integrated fuselage / empennage to reduce production waste and increase material and energy exploitation with Integrated Fuselage concept selected (maturity TRL3/4) until end of first phase in 2025. An anticipated route to TRL6 until end of the Clean Aviation programme in 2030 will ensure entry-into-service in 2035.

Keywords: aircraft,airframe,fuselage,empennage,hydrogen,cabin
Polyphonic Philosophy: Logic in the Long Twelfth Century (c. 1070-1220) for a New Horizon in the History of Philosophy (PolyphonicPhilosophy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1498215.0
EU funding (EUR): 1498215.0
Participants: 1
Project status: SIGNED

This project aims at an innovative, interdisciplinary approach to Latin logical commentaries from the Long Twelfth-Century (c. 1070-1220). My contention is that this little-explored topic presents us with a unique "Polyphonic Philosophy" that can open up a new horizon in our understanding of philosophical commentaries, on the one hand, and help to reshape some core ideas in the history of philosophy, on the other - at a time when both are urgently needed. A team of four postdoctoral researchers led by the PI will actualise the potential of some extraordinary preliminary material to study a wealth of 12th-century manuscripts of mainly unpublished texts with novel concepts. We will have three objectives: 1. A comprehensive study of 12th-century logical manuscripts as the main units for accessing this complex field, in which the notions of unitary text and author have proven challenging. 2. A study of mainly unpublished logical texts from a "polyphonic" perspective that will follow a comparative, archaeological and analytical approach and develop some pioneering digital scholarly editions of texts to model their polyphony. 3. Meta-analysis of the concepts used from an interdisciplinary and historiographical perspective, offering new insights into the key concepts of the project and non-solo paradigms to reconstruct philosophy's past. The project will require interdisciplinary expertise in digital medieval studies, digital textual criticism, codicology, the history of education, the history of literacy, the social history of logic, the history of philosophy, and the historiography of philosophy. Following a concrete-to-abstract highly integrated research design, taking advantage of recent methodologies, this project has the ambitious goal of opening up an entirely new horizon for the history of philosophy, while also impacting on several other areas, from medieval studies, to the history of universities, to the study of commentaries more generally.

Keywords: philosophical commentaries,latin medieval logic,long twelfth century,peter abelard,boethius,manuscripts,edition of latin logical texts,historiography of philosophy,twelfth century schools
Highly Efficient Reactor for Conversion of CO2 and H2O to Carbon Neutral Fuels and Chemicals (HiCon)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Greece,Estonia,United Kingdom,Italy,Netherlands
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 2250500.0
EU funding (EUR): 2250500.0
Participants: 7
Project status: SIGNED

A novel, highly efficient technology, to enable the synthesis of Carbon Neutral Fuels and Chemicals from CO2 and H2O employing renewable energy is proposed. The approach is based on an innovative reactor technology that produces cost-effectively green precursors for Carbon Neutral Fuels and Chemicals. The technology enables operation at non-demanding, low temperatures with unprecedented efficiency that overcomes many of the key challenges of existing technologies, exploiting radical innovations in materials and reactor engineering. The modular, easily scalable, reactor design can be integrated in/ coupled to a number of technological values chains, processes and industrial sectors, providing a sustainable pathway to net zero and achieving the European decarbonization goals. This is a cross-cutting, transformative technology for energy intensive industries, while maintaining the value of past investments in existing infrastructures (e.g. in downstream hydrocarbon processing, power generation technology, automotive industry). As such it consists of a real “just transition”, one that “leaves no one behind” as it does not disrupt the fabric of the society by marginalizing the specialized and capable European workforce in these sectors. The consortium consists of seven partners from five countries and includes a well-known university, an internationally leading energy company, a specialized materials and chemicals company, a multi-technology renewable energy developer and 3 innovative SMEs in clean energy & mobility and advanced electronics.

Keywords: carbon neutral,energy carriers,structure reactor,redox materials