Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Probabilistic Integration Recurrent Neural Network for Scientific Applications (PRINN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 413379.72
EU funding (EUR): 413379.72
Participants: 2
Project status: SIGNED

Scientists have huge needs for better analysis tools. Machine learning is a powerful framework to provide outstanding tools, but the current large-scale neural networks are not adapted for scientific applications where datasets are limited. Probabilistic networks are a powerful alternative for smaller datasets. However, they have flaws that prevent them to work well for complex tasks. They notably have speed and accuracy limitations. This project aims to make a breakthrough in machine learning for scientific applications by developing a new physics-informed probabilistic neural network adapted for small datasets. The basic unit of our network overcomes the limitations of the current probabilistic methods by considering a recurrent Gaussian process and using an analytical integration method. The first objective of our project is to deploy several units that each represent a state in a neural network, and to consider abrupt transitions from one state to another. This network will be applied to the analysis of single-particle tracking data, an important and complex biology problem for which our model will be particularly well-suited. Next, we will extend our network to consider maps and spatiotemporal maps. This second phase will be applied to mapping cell viscosity, a particularly promising super-resolution technique that does not require specific markers. Our last objective is to create a modular network to enable better scalability of our architecture for more complex tasks. We will test this architecture on multimodal data like vital signs to predict patient outcomes. This project will therefore result in a powerful open-access neural network that other scientists will be able to derive for their scientific applications, along with a series of three scientific tools that will redefine the state-of-the-art in their respective fields and for which we expect a large use.

Keywords: neural networks,machine learning,probability,statistics,signal processing,kalman filtering,single particle tracking,sequential data,mapping,denoising weather forecasting,patient outcomes
Architecture of Peripheral Neuroimmune Circuits and Synapses (NeurImmKisses)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 3500000.0
EU funding (EUR): 3500000.0
Participants: 1
Project status: SIGNED

Maintenance of health requires the coordination of multiple cellular networks. For example, the immune and nervous systems cooperate to regulate tissue homeostasis. In agreement, our recent work demonstrates that innate lymphoid cells (ILC) integrate neuronal signals to control tissue health and immunity. These findings are provoking a paradigm shift in our understanding of the immune response, neuroimmune crosstalk and its potential therapeutic value. Nevertheless, the dynamics of neuroimmune modalities remain elusive, and progress in the field has been hindered by the lack of approaches to explore the identity and plasticity of neuroimmune interactions in vivo. Here, we hypothesise that dynamic circuitry codes orchestrate neuro-ILC2 interactions and disease outcomes. To test this hypothesis, we have developed a set of disruptive intercellular labelling neuroimmune toolboxes that we termed KISS and LIPSTIC, and which can probe the dynamics of neuro-ILC2 axes in vivo, with cellular specificity and single-cell resolution. Using these innovative platforms, we plan to unravel the architecture of pulmonary neuro-ILC2 circuits and to define cellular identities, outcomes, and plasticity at the neuroimmune interface. Sequentially, we propose to unravel unappreciated neuro-ILC2 synaptic communication and to define the ultrastructure of theses intercellular entities using high-resolution imaging. Finally, by conditionally harnessing the activity of synaptic neuronal partners during airway inflammation and infection, we will investigate their impact on ILC2, their environment, and on disease progression. Together, these experiments will tackle multiple facets of pioneer, frontier questions, bringing to bear an array of cutting-edge technologies to address and advance, with unprecedented mechanistic and conceptual detail, how the neuroimmune interactome unfolds, in health and disease.

Keywords: innate lymphoid cells mucosal immunology neuroimmune interactions intercellular labelling systems
The synergy of Cement and Biomass-derived Carbon composite for Sustainable Energy Storage Solution (BIOMENTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-06
End date: 2028-01-05
Duration (months): 24.0
Total project cost (EUR): 179006.16
EU funding (EUR): 179006.16
Participants: 1
Project status: SIGNED

Contemporary energy storage technologies, such as batteries and fuel cells, grapple with issues of power density, longevity, and safety. Supercapacitors present a viable alternative with their high-power density, extended cyclic life, wide operational temperature range, and superior safety. The main hurdle for supercapacitors is their moderate energy density, which is vital for storing renewable energy efficiently. Research is honing in on novel materials to boost energy density and synthesis techniques to augment electrochemical performance. With environmental and material availability concerns in mind, the focus has shifted to accessible and eco-friendly materials like biomass and cement. The proposed research aims to develop supercapacitor electrode materials from cement—a construction industry mainstay—and activated carbon from plentiful organic biomass. Cement's inherent poor conductivity and low surface area might limit its electrochemical efficacy, but pairing it with conductive materials could leverage its potential for both building and energy storage. The research will delve into the Cement/AC composite for supercapacitor electrodes and will craft and evaluate a supercapacitor with an apt gel electrolyte for real-world use. The study will experiment with different cement-to-activated carbon ratios and preparation methods to refine the qualities needed for a potent supercapacitor electrode. This research could lead the way in energy storage innovation, enabling rooftop structures to harness and store energy from renewable sources such as solar power.

Keywords: structural supercapacitor,cement,activated carbon,composite electrode
Precision measurements in molecules with frequency combs (COMB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 3218398.76
EU funding (EUR): 3218398.75
Participants: 2
Project status: SIGNED

Precise frequency measurements enable accurate determinations of physical constants, stringent tests of fundamental theories and searches for possible drifts of the fundamental constants. Simple atoms, hydrogen in particular, have long been the dedicated systems for confronting experimental data and accurate quantum electrodynamics theoretical calculations. With continued progress to ab initio calculations, precision measurements in small molecules, such as molecular hydrogen H2, are gaining much relevance and may be envisioned as an independent way to determine fundamental constants and to test quantum-chemistry theory. In this project, we will develop an instrument of precision molecular spectroscopy, based on frequency combs, broad spectra composed of equidistant narrow lines whose absolute frequency can be known within the accuracy of an atomic clock. Building on our unique know-how, this revolutionary ultraviolet spectrometer will simultaneously combine broad spectral coverage, Doppler-free resolution and extreme accuracy for precise studies of small molecules. Using two-photon excitation and dual-comb spectroscopy with comb lasers of low repetition frequency, we will devise an optical analogue of the Ramsey-fringe method where many molecular transitions will be simultaneously and unambiguously observed and assigned. While such a spectrometer will enable significant progress in our understanding of the structure of many small molecules, it will first be applied to absolute-frequency measurements of rovibronic transitions in the EF – X system of H2 around 3000 THz. The measured frequencies can be used to benchmark molecular theory in the involved ground and excited states. They may contribute to an improved determination of the dissociation energy of H2, set new basis for an independent determination of the proton-charge radius and for searches of variations of the proton-electron mass ratio via comparison to astrophysical measurements.

Keywords: optical frequency combs precision spectroscopy molecular spectroscopy frequency metrology tests of fundamental physics
THE FIRST PORTABLE MASS SPECTROMETER DEVICE FOR RAPID, ON-SITE FOOD CONTAMINANT TESTING (SAFE-FOOD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 2280212.75
EU funding (EUR): 1596148.93
Participants: 1
Project status: CLOSED

Lengthy, effort-consuming lab-based procedures for food contaminants detection led to delays in supply chains, excessive food waste, economical losses, and illness of the consumers. NG Sensors applied its proprietary mass spectrometer (MS)-based technology to develop a Handheld Molecular Contaminants Screener (HMCS), a portable and user-friendly device to assess contaminations on-site in realtime. This is the first time that an MS is miniaturized without compromized sensitivity. HMCS offers cost-effective and time-saving contaminant assessment compared to current lab-based testing significantly reducing food waste and CO2 emission. We will generate revenues from HMCS sales and service contracts to food/feed processing companies in the Agri-food Testing market. The SAFE-FOOD project focuses on commercial, regulatory and pilot studies to ensure HMCS’ market readiness and commercialization to its market launch in 2023 that forecasts an annual revenue of €2.75M rising to €74M in 2027.

Keywords: novel materials,food contamination,design innovation,mass spectrometry,automation,traceability,blockchain technology
GovErning humaN rights through partnErShIpS: investigating the normative and operational interface of international law and multistakeholder governance (GENESIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1488784.0
EU funding (EUR): 1488784.0
Participants: 1
Project status: SIGNED

The 2030 Agenda for Sustainable Development and the Sustainable Development Goals hail multistakeholder partnerships (MSPs) as key actors in achieving sustainable development. MSPs that bring together states, businesses, philanthropy and civil society are increasingly in the frontlines of providing public goods that are human rights such as food, health, education and water. In these domains, partnerships are spearheading the continued expansion of multistakeholder governance into international law, including human rights law. This expansion has been taking place without critical appraisal with respect to its effectiveness and consequences.GENESIS breaks new ground by exploring the normative and operational implications of this shift, both at the system-level and at the level of specific global partnering initiatives and individual multistakeholder partnerships. GENESIS investigates the interface of international law and multistakeholder governance in the realisation of human rights. It analyses how the paradigms of multilateralism and multistakeholderism diverge or converge as they simultaneously govern the domains of food, health, education and water through human rights law and multistakeholder partnerships, respectively. GENESIS has three main objectives that will generate high research and policy gains. First, GENESIS will uncover and understand how norms that govern human rights through multistakeholder partnerships are made in the post-2015 era in the governance of food(SDG 2), health (SDG 3), education (SDG 4) and water (SDG 6). Second, GENESIS will investigate how multistakeholder partnerships impact the way human rights are operationalised. Third, GENESIS will identify pathways to an effective uptake of human rights legal standards by multistakeholder partnerships. In doing so, GENESIS will derive insights on whether and how international law and multistakeholder governance can generate common ground when governing public goods that are human rights.

Keywords: human rights,multistakeholder partnerships,multistakeholderism,multilateralism,governance,public goods
Towards a strategy to preserve deep-sea biodiversity: understanding deep-sea evolution and diversification drivers of hyperdiverse marine invertebrates (DEEPDIVERSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

For centuries, biologists have been intrigued by how diverse our planet is and what processes are behind it. But we are far from knowing how many species live on Earth, especially for deep-sea invertebrates. The deep ocean provides a particular scenario for diversification and remains relatively pristine. However, soon programmed deep-sea mining activities threaten deep-sea diversity even before its discovery. Squat lobsters are highly diverse at all levels and an ideal group to undertake a critical assessment of deep-sea diversity and evolution. For DEEPDIVERSE I propose to follow up a conceptual framework towards an evaluation of global species diversity of squat lobsters to assess the role of depth and deep-sea habitat in the diversification dynamics, supporting at the same time scientific research and conservation of deep-sea diversity. The action proposes 1) Beyond-taxonomy: a critical appraisal of squat lobster biodiversity combining extensive ecological, biological, morphological, and genetic traits, using 3D micro-computed tomography, barcoding with high-throughput sequencing, automatic species delimitation analyses, and formal species descriptions; 2) Phylogenomic reconstruction using target capture sequencing (UCEs) and integrating fossil taxa to set the base to understanding the evolutionary processes behind deep sea colonisation; 3) searching for diversification drivers to unveil factors shaping morphological evolution and potentially shifting diversification rates; and 4) Synthesis of the results towards the implementation of conservation actions comparing with other hyperdiverse taxa. This includes a comprehensive spatial data integration to guide the best available management options for global seafloor biodiversity. These actions will contribute to the efforts of the European Union Biodiversity Strategy for 2030, within the European Commission priority A European Green Deal, to tackle the outstanding Biodiversity crisis the World is currently facing.

Keywords: crustacea,evolution,deep sea,biodiversity,taxonomy,genomics,ultraconserved elements
REsilienT water gOvernance Under climate CHange within the WEFE NEXUS (RETOUCH Nexus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Netherlands,Slovakia,France,Belgium,Malta,Italy
Call: Water governance, economic and financial sustainability of water systems (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2994746.75
EU funding (EUR): 2994746.75
Participants: 13
Project status: SIGNED

With increased water scarcity due to anthropocentric and natural causes, the trade-offs and synergies intrinsic to efficiently allocate water resources to various competing uses have become more polarized. Realizing the importance of an integrated approach in water governance, the RETOUCH Nexus project introduces and promotes the Water-Energy-Food-Ecosystems (WEFE) Nexus as a multi-level and cross-sectoral approach that advocates the EU water economy and, in addition, relies on ecological and social considerations. The overall objective of RETOUCH Nexus is to design and foster integrated, innovative and inclusive Nexus-smart water governance schemes and institutional settings to promote a secure water future in the EU, resilient to climate change. RETOUCH Nexus follows an evidence-based approach to propose, assess and optimize a set of WEFE Nexus smart methods in six different case studies reflecting various cross-sectoral, multi-level and multi-stakeholder water governance contexts. First, the project will monitor water governance by providing a set of Nexus-smart socio-economic and environmental indicators that reflect the cross-sectoral and multi-level nature of water use. Second, RETOUCH Nexus will design integrated and climate-resilient water governance practices that ensure sustainable water systems. It will also develop economic instruments and business models that support robust water management under cross-sectoral competition. Third, RETOUCH Nexus will foster more transparent, inclusive and innovative engagement mechanisms that empower stakeholder and citizen participation in water governance. Finally, RETOUCH Nexus aims to effectively increase the socio-economic and environmental resilience of water governance in Europe by upscaling and endorsing successful and sustainable Nexus-based water governance interventions that will be designed and validated throughout the duration of the project.

Keywords: water,governance,nexus,monitoring,economics,business,policy,citizen,engagement
Hop-on-Mopo to develop advanced energy system modelling tools (Hop-on-Mopo)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Latvia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 584258.0
EU funding (EUR): 584258.0
Participants: 2
Project status: SIGNED

The overall objective of Mopo is to develop a validated, user-friendly, feature-rich, innovative and well-performing energy system modelling toolset to serve public authorities, network operators, industry and academia to plan sustainable and resilient energy systems in a cost-effective manner. Riga Technical University (RTU) joins the Mopo project to enhance four aspects of the Mopo project: RTU enhances the capability of the Mopo tools to model transmission systems while including the impact of distribution grids. This contributes to the WIDERA call topic as it mobilizes excellence from a Widening country, and it also contributes to the call topic of the Mopo project by enhancing the modelling capabilities of the Mopo tools to better plan and optimise the expansion of the energy systems in Europe. RTU demonstrates how the Mopo component tools can be used to build a regional case study enhanced with local data. This contributes to the call topic requirement to construct validated and open-source component tools to serve the modelling needs of public administration and network operators. RTU demonstrates the capabilities of the Mopo tools to perform detailed regional studies while co-modelling the European system, which contributes to the call topic requirement to validate the modelling framework in real-life case studies. RTU creates high-quality course material suitable for students and professionals, which aims to increase the impact of the Mopo project. While Mopo project aims to benefit 60% of network operators and public authorities within 2 years of the project end, Hop-on-Mopo would increase this target to 80%. The tools will be modular, which allows different organisations to adopt the parts that benefit their existing modelling systems.