Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MOLECULAR CARPETS ON INSULATING SURFACES: RATIONAL DESIGN OF COVALENT NETWORKS (SURFLINK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2021-04-30
Duration (months): 72.0
Total project cost (EUR): 1499994.0
EU funding (EUR): 1499994.0
Participants: 1
Project status: CLOSED

Inspired by the possibility to create artificial, three-dimensional covalent organic frameworks, the overall aim of this project is to construct novel two-dimensional (2D), covalently-linked, organic networks in a bottom-up approach on insulating surfaces. 2D materials have unique properties suitable for many scientific and technological applications including nano-electronic devices and sensors. On-surface synthesis of covalent structures is mainly limited to metal surfaces, as controlled growth procedures of molecules on insulators are often hindered by the weak, unspecific interaction with the substrate. We will establish suitable concepts for the covalent linking of molecules on insulators by balancing the molecule-molecule and molecule-surface interactions. That will greatly advance the atomic-scale understanding of molecular structures on insulators. Specially designed molecular building blocks doped with heteroatoms will be used to create functional 2D networks with tunable electronic properties and nanometer-sized pores. Novel concepts will be developed to achieve high quality structures with long-range order; one of the great challenges in all covalently-linked structures. The SURFLINK project uses a surface science approach in ultra-high vacuum to understand the fundamental mechanisms and properties of covalently-linked networks at the atomic level. The covalent networks will be studied by high-resolution scanning probe microscopy and spectroscopy at the atomic-scale. We will determine the electronic properties of the novel nano-porous networks that can be tailored by their geometry. The functionalized pores included in the network will be studied with respect to their size and their prospects to adsorb guest molecules. The rational design of the networks proposed in the SURFLINK project has great potential for materials research and will ultimately result in the development of new materials with adjustable electronic properties.
Lab-in-a-patch for PKU self-assessment (LABPATCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Phenilketonuria (PKU) is a congenital metabolic disease related to high levels of phenylalanine (Phe) in blood that, if not treated, can lead to intellectual disability, behavioural problems, and mental disorders. Life-long monitoring of Phe levels are necessary for PKU patients to avoid health (mainly neurological) issues. Currently available techniques for Phe assessment are costly, slow and take place only in clinical chemistry laboratories inside tertiary care hospitals, with a total analysis rate of one test every 1 month. Therefore, new technologies for frequent and rapid Phe analysis are required to improve PKU therapeutic efficacy, health monitoring and hence the quality of life of the patients. Here, we propose a fully integrated wearable patch for non-invasive self-assessment of PKU. The patch is designed to comfortably detect sweat Phe levels at home settings without medical expertise or expensive facilities. The patch contains electrodes modified with Phe-selective bioreceptors and is connected to a miniaturized controlling unit for electrode operation and wireless data transmission to external devices (smartphone, tablet, etc.). Overall, this project will provide, in an unprecedented manner, the fast monitoring of a rare disease with an integrated, compact, user friendly and non-invasive device. We aim at improving the way patients and doctors interact regarding the daily assessment of PKU. The produced devices will change how this rare disease is monitored, understood and will open new correlations between PKU and degree of health of patients. Furthermore, we expect that the concept of Lab-in-a-patch device proposed in this project will pave the way to the monitoring and assessment of other specific diseases.

Keywords: lab in a patch,phenilketonuria,fast non intrusive monitoring,device,bioreceptors
Transitions pathways and risk analysis for climate change mitigation and adaption strategies (TRANSrisk)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Switzerland,Greece,Greece,Sweden,Poland,Netherlands,Netherlands,Netherlands,Chile,United Kingdom,United Kingdom,United Kingdom
Call: Economic assessment of climate change (H2020-SC5-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2018-12-31
Duration (months): 40.0
Total project cost (EUR): 7974242.5
EU funding (EUR): 7454017.5
Participants: 14
Project status: CLOSED

Both the models concerning the future climate evolution and its impacts, as well as the models assessing the costs and benefits associated with different mitigation pathways face a high degree of uncertainty. There is an urgent need to not only understand the costs and risks associated with climate change but also the risks, uncertainties and co-effects related to different mitigation pathways as well as public acceptance (or lack thereof) of low-carbon (technology) options. The main aims and objectives of TRANSrisk therefore are to create a novel assessment framework for analysing costs and benefits of transition pathways, that will integrate well-established approaches to modelling the costs of resilient, low-carbon pathways with a wider interdisciplinary approach including risk assessments. In addition TRANSrisk aims to design a decision support tool that should help policy makers to better understand uncertainties and risks and enable them to include risk assessments into more robust policy design.

Keywords: climate change,mitigation,adaptation,cost benefit,risk
Drug Absorption in Geriatric Patients and Older People: a training network innovating drug development for the advanced age population (AGePOP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Belgium,Switzerland,Greece
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2790443.16
EU funding (EUR): 2790443.16
Participants: 6
Project status: SIGNED

The advanced age population (>65y) makes up ~20% of the total population in Europe, is the main carrier of chronic diseases and the major end-user group of medications. Yet, despite an ageing society, these end-users are entirely disregarded in the drug development process, which considers only healthy adults aged 18-55. Effective absorption of oral drugs, which remain the preferred form of administration, relies on a sound knowledge of the physiological alterations associated with ageing and of the characteristics of the gastrointestinal (GI) tract in older subjects. Nonetheless, both the knowledge and the experts in this area are lacking. The AGePOP European Training Network (ETN) will boost Europe’s innovation capacity and leadership in oral drug development. Its multisectoral approach will train 11 Early Stage Researchers (ESRs) to become the future experts in drug development for the advanced age population, shedding a much needed light on the needs of our ageing society. With an open science philosophy and a multidisciplinary strategy, the ESRs will collect the first ever dataset of physiological characteristics of the GI tract of older people and geriatric patients, developing novel in vitro and in silico tools, e.g. a mobile test kit to evaluate gastric emptying kinetics and an absorption risk calculator to predict adverse effects from altered pharmacokinetics. Complementary training in transferable, business and wider horizon skills will equip the ESRs with an all-rounded skillset. AGePOP is a network of 6 Beneficiaries and 7 Partner Organisations from 5 European countries. Its 3 academic partners with research excellence in oral drug products synergise with renowned clinicians and researchers from 8 leading pharma companies and 1 SME specialised in ETN training. Building on long-standing collaborations, the consortium will provide 11 ESRs with a unique Europe-wide learning experience, preparing them to lead their future careers with confidence and success.

Keywords: oral drug development,dosage form,absorption,geriatric patients,advanced age,biopharmaceutics,in vitro tools,pbpk modelling,gastrointestinal physiology,parkinson s,alzheimer s,diabetes
Evolution of genetic network required for fruit and fruit-like structures development of land plants. (EVOfruland)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Australia,Spain,Italy,Colombia,United States,Netherlands,Brazil,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 1007400.0
EU funding (EUR): 662400.0
Participants: 14
Project status: SIGNED

Human and animal nutritional needs are mainly based on the intake of seeds and fruits which are also sources of other priceless products useful for our own well-being. For the plants themselves, the fruits are a key to seed dispersal and ensure future plant generations. Although fruits show diverse structural and seed dispersal mechanisms across flowering plants it seems that all species might share a common developmental network. Fruits, in the strictest sense, are only present in angiosperms and are mainly derived from the ovary wall. Nevertheless, fruit-like structures, used for seed dispersal are present also in Gymnosperms. This research project proposes to build an intercontinental and interdisciplinary network with the aim to elucidate the evolution of the molecular signaling and the crosstalk among different players that underpin the development of fruit and fruit-like structures. We will focus on: a) the functional evolution of key transcription factors known to be integral for fruit and fruit-like development. To build the Fruit evolutionary conserved Genetic Regulatory Network (FGRN) we will consider core eudicots such as Aethionema arabicum, the orphan crops Lepidium campestre, Solanum lycopersicon and Passiflora edulis. We will include also non-core/early diverging eudicots: Papaver somniferum, and Aristolochia fimbriata and the gymnosperms Ginkgo biloba and Taxus baccata. b) the hormonal signaling involved in the coordination and synchronization of the steps of fruit/fruit-like development c) cell wall pathways involved in pectin maturation and cellulose deposition required for fruit development. We will use a broad set of approaches such as molecular genetics, evolutionary genomics, biochemical and biophysical analyses. The consortium will be engaged in a large program of communication and dissemination of these topics with the involvement and outreach efforts of three Botanical Gardens.

Keywords: fruit development,plant hormone cross talk,plant cell wall composition
Strengthening the Capabilities and Training Curricula for Conflict Prevention and Peace Building Personnel with ICT-based Collaboration and Knowledge Approaches (PeaceTraining.eu)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Germany,Spain,Estonia,Austria,Germany,Romania,Belgium,United Kingdom,United Kingdom,Kosovo
Call: Conflict prevention and peace building topic 2: Training curricula for Conflict Prevention and Peace Building personnel (H2020-BES-2015, 2015)
Start date: 2016-09-01
End date: 2018-10-31
Duration (months): 26.0
Total project cost (EUR): 1499920.0
EU funding (EUR): 1499920.0
Participants: 12
Project status: CLOSED

Political conflicts have long since gone beyond national borders and peace building has become central to the self-conception of the European Union as a foreign policy actor. Current challenges in Conflict Prevention and Peace Building (CPPB) trainings are that many programmes on offer are both too general/narrow, they are not applicable enough, weak on concrete skills enlargement and moreover training alone is not sufficient. Overcoming these challenges requires novel CPPB training curricula and linked activities. PeaceTraining.eu aims to analyse these issues with strong involvement of all relevant stakeholders to take into account current practices and provide new training methods for CPPB personnel. In order to meet these challenges and to investigate this complex field of research a multidimensional modeling approach is used. The resulting, proprietary PeaceTraining.eu Cube Model describes curricula structures including stakeholders, new methods, course structures, techniques as well as further aspects, e-approaches, tools and entities. The PeaceTraining.eu Web Platform (www.peacetraining.eu) features a knowledge base, stakeholder maps, expert navigators, infographics, best practice libraries, and digital guidebooks to strengthen the information transfer among all project developments and future implementations. Additional Training Curricula Setup Utilities and Search Tools four training centres and trainers are provided through the project. Thus, PeaceTraining.eu increases awareness on the topic and also attracts secondary target groups including training course provider, educational institutions and trainers because of its sustainable strategy with long-term mobilisation and engagement activities including an International PeaceTraining.eu Symposium. On a European scale, PeaceTraining.eu will deliver new CPPB training methods and curricula and serve as a one-stop resource to increase efficiency and reduce costs.

Keywords: assessment,capabilities,gaps,csdp,co creation,standardisation,visualisations,web platform,knowledge base,multidimensional curricula model,european stakeholder map,expert navigator
A DUAL gRNA system for functional assessment of ENhancers in Pluripotency (DUALgRENP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Enhancers are cis-regulatory genomic regions that can modulate gene expression in a cell type-specific and time-controlled manner to regulate cellular behaviour. ChIP-seq and RNA-seq technologies have allowed genome-wide identification of potential enhancers based on the correlation among specific chromatin marks, transcription factor biding sites and gene expression. However, strategies to validate their function are still limited. Recently, it has been demonstrated that the CRISPR/Cas9 genome editing technology can be used to delete large genomic regions at high frequency by co-transfection of two guide RNAs (gRNAs) targeting collinear genomic sites and subsequent NHEJ-mediated repair. Nevertheless, this system is limited to individual tests. Here we aim to generate a novel lentiviral dual-gRNA expression system that enables large scale functional enhancer screening. The candidate will apply this dual-gRNA expression system to generate custom libraries that will allow the functional identification and subsequent validation of essential enhancers for the maintenance of mouse Embryonic Stem (mES) cell identity. This technology will provide a comprehensive view of the function of enhancers within their genomic context and will enable for the first time the performance of systematic, genetic forward enhancer screens.

Keywords: stem cells,enhancers,crispr,cas9,forward genetic screens
Get on top of your multimedia content (ASSIGN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 96250.0
EU funding (EUR): 96250.0
Participants: 1
Project status: CLOSED

The ASSIGN proposal aims to overcome barriers to the recruitment of highly qualified specialists (PhD or equivalent) that cannot be recruited on the national job market, but whose knowledge would be crucial to open up opportunities for innovation and significant growth for the enterprise. With ASSIGN we expected that the Innovation Associate who will be hired will catalyse the radical product innovation of the company’s multimedia content management and publishing platform. The main expertise and skills of the Innovation Associate we expect to source with this recruitment are in the area of semantic multimedia content analysis and indexing, primarily in the domain of image and video and secondary in the domains of text, speech and audio analysis. We foresee a permanent post for the Innovation Associate after the end of the grant and plan to commercialise the innovation developed in the vertical markets of company/enterprise content, team/project content, branding and event content. IN2 is very well positioned to supply the Innovation Associate with training in current and trending topics in the area of web software development, that are very much needed in the labour market. With our private cloud and our engagement in application deployment (DevOps) we give to the Innovation Associate additional know-how to advance professionally in areas that can cover the complete software innovation cycle. Moreover, the Innovation Associate will benefit from gaining valuable insights into commercial innovation management and business aspects.

Keywords: multimedia,software,content analysis
Large area interferometric imager for highly sensitive inspection of materials (LIM)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-10-01
End date: 2022-09-30
Duration (months): 12.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project aims at applying and exploiting a novel type of imaging technology, a large area interferometric imager (LIM), which was largely developed within the FET project Q-MIC. More specifically, we will analyse customer-relevant samples, evaluate the performance of prototypes in industrial environments and potentially adapt them to specific needs, and finally perform full market assessment and commercialization plan for the proposed technology. This in close collaboration with companies, which have already shown interest in using the technology as measurement, inspection tool or integrating it into their existing imaging systems. The LIM allows imaging of large sample areas and volumes with unprecedented sensitivities (a few atomic layers of material). Thanks to a close reference scheme, the technology is inherently very robust while also offering the possibility of compacting it in a small form factor. All these features are attractive for material analysis and in-line inspection, essential in the high-tech semiconductor, glass, photonic, and display industries.

Keywords: large area,interferometric,machine vision,material inspection,phase imaging,transmission and reflection,compact,inexpensive,robust and stable,nanostructures,highly sensitive,quality control
European Research Infrastructure supporting Smart Grid Systems Technology Development, Validation and Roll Out (ERIGrid)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Germany,Spain,Spain,Italy,Austria,Greece,Norway,Finland,Greece,France,France,Netherlands,Netherlands,Denmark,United Kingdom
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-11-01
End date: 2020-04-30
Duration (months): 54.0
Total project cost (EUR): 9999987.0
EU funding (EUR): 9999987.0
Participants: 25
Project status: CLOSED

Renewable energy sources are key enablers to decrease greenhouse gas emissions and to cope with the anthropogenic global warming. The intermittent behaviour of them and their limited storage capabilities present new challenges to power system operators in maintaining power quality and reliability. However, the increased availability of advanced automation and communication technologies has also provided new intelligent solutions to these challenges. Previous work has presented various new methods to operate highly interconnected power grids with corresponding components in a more effective way. As a consequence of these developments the traditional power system is transformed into a cyber-physical system, a Smart Grid. Previous and ongoing research activities have mainly focused on validating certain aspects of Smart Grids, but until now no integrated approach for analysing and evaluating complex configurations in a cyber-physical systems manner is available. The lack of system validation approaches for Smart Grids is especially addressed by ERIGrid. By providing a Pan-European research infrastructure ERIGrid supports the technology development as well as the roll out of Smart Grid solutions and concepts in Europe. It tackles a holistic, cyber-physical systems based approach by integrating 18 European research centres and institutions with outstanding research infrastructures and jointly develops common methods, concepts, and procedures. ERIGrid also integrates and enhances the necessary research services for analysing, validating and testing Smart Grid configurations. System level support and education for industrial and academic researchers in is provided as well to foster future innovation. ERIGrid addresses these challenging aims by providing a single entry point to the provided research infrastructure and offering a broad spectrum of services to researchers active in Smart Grids. This will strengthen the technical leadership of Europe in the energy domain.

Keywords: smart grids