Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From Mimicry to Trust: A Tinbergian Approach (CoPAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2026-05-31
Duration (months): 84.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Many daily decisions are made through quick evaluations of another’s trustworthiness, especially when they involve strangers. Individuals rely on a partner’s tractable characteristics, including expressions of emotion. These are readily mimicked even down to the physiological level. I here propose to investigate which forms of mimicry are empathic and inform decisions of trust and distrust. The mimicry-empathy linkage has come under discussion with the publication of counter-examples in biology and failures of replication in psychology, making the question of what mimicry entails even more important. The key role emotional expressions play in our daily life positions this revived debate around mimicry at the forefront of emotion science. Scientific advancement in this field, however, demands a completely new theoretical and methodological approach. Therefore, I will place mimicry within the Tinbergian framework. Fundamentally, this means that I will incorporate biological and psychological approaches to the study of mimicry and during dyadic interactions, investigate different forms of mimicry simultaneously, e.g. facial mimicry, contagious blushing, pupil mimicry, and their 1) Function: what they are good for. Using economic games, I will study which mimicry forms are related to empathy and inform social decisions; 2) Mechanism: how they operate on the neurophysiological level; 3) Development: how mimicry develops over the lifespan and which mimicry forms are phylogenetically continuous and shared with the bonobo, our closest living relative and link to our last common ancestor. For the first time, humans and bonobos will be directly compared on the basis of their mimicry and trust. This comparison can revolutionize the way humans perceive themselves when it comes to prosocial behaviour.

Keywords: bodily maps of emotion,expression,emotional contagion,empathy,eye contact,evolution,comparative psychology,mimicry,pupil size,physiological linkage,social neuroscience,social interaction
Enhancing brown adipose tissue through NAD+ precursors: a new approach to treat cardiometabolic disease (eBAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Cardiometabolic disease comprises a group of disorders including obesity, hypertension, dyslipidaemia, hypercholesterolaemia and glucose intolerance. These are the underlying cause of the majority of cardiovascular diseases, which represent the leading cause of morbidity and mortality in the Western World. The discovery of active brown adipose tissue (BAT) in adult humans in 2009 has increased the interest on the role of this tissue in the development of these disorders, and in the potential of its metabolic activation for their treatment. It has been demonstrated that BAT activation can be achieved by means of supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). However, very little is known about how these compounds exert their effect on BAT and what the metabolic effects of their administration to this tissue are. This project proposes the use of an undescribed NAD+ precursor to induce BAT activation. I have already proved that this new compound is a more powerful NAD+-booster than NMN and NR. Thus, I hypothesize that it will be able to enhance BAT function more pronouncedly. By testing the effects of the supplementation of different cell lines and mouse models with this new compound, I aim to elucidate the molecular mechanisms underlying its NAD+-enhancing potential and the physiological changes that BAT undertakes upon its administration. Moreover, its encapsulation in nanoparticles for its oral administration through the diet will also be tested. This will be of outstanding relevance for its possible pharmacological use. The development of the research aims proposed in this project will shed light on the use of NAD+ precursors to activate BAT function, with the long-term ambition of establishing whether the use of these compounds is a suitable approach for the protection from cardiometabolic disease through the preservation of BAT phenotype.

Keywords: nad precursors,brown adipose tissue,sirtuins,cardiometabolic disease,metabolic flux,nad precursor transport
Cellular mechanisms of predictive processing and its effects on perception (MECHPREDPRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Predictive processing is a leading theory of brain function. However, despite several conjectures it is unknown how predictive processing is implemented at the neural level. We will try to understand the exact role of the computations of the layer 5 pyramidal (L5p) cells within the framework of predictive processing. The experimental paradigm and the computational model used here are designed to answer, whether L5p cells carry predictions, as the theory of predictive processing suggests, or are they responsible for some other computation. To this end we will a) adapt experimental paradigms used with humans to study probabilistic computations in the mouse model, b) measure the dendritic input and somatic output of L5p cells in mice, c) capture this activity with computational models and d) manipulate the apical dendritic input and somatic output of L5p through noradrenaline antagonists. The project allows us to understand the mechanisms underlying predictions and their effect on perception.

Keywords: predictive processing,layer 5 pyramidal cells,illusory perception
Training research pioneers by utilizing and validating the promise of electroporation for minimal invasive oncological treatments. (ElectroPros)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1023985.08
EU funding (EUR): 1023985.08
Participants: 3
Project status: CLOSED

The ElectroPros action aims to optimally prepare young researchers for the evolving technology in the healthcare space, especially related to minimal invasive oncology therapies, by offering a unique set of targeted interdisciplinary training and research assignments in the areas of biophysics modelling and simulation, device physics, optimization algorithms, software integration and experimental validation. Four European Industrial Doctorate positions are offered to Early Stage Researchers (ESRs) for a period of three years. In the training program a combination of industrial, academic and clinical research environments are provided by Philips, the University Clinic Aachen and RWTH Aachen, to explore the field of electroporation, as a new and promising technique for minimal invasive oncology treatment. Based on sound career development plans, and coached by experienced supervisors, the four ESRs involved will develop a competence profile which will springboard their future career in the wide European medical community in the industrial, clinical and academic domain. These researchers have the potential to become pioneers for new minimally-invasive therapies for the oncology domain. During their training, the ESRs will work on electroporation based treatment of cancer. The ESRs address shortcomings of the currently available equipment to enable for the first time ever a reliable patient-specific electroporation based treatment for cancer. With a focus on liver cancer, the ESRs will collectively establish novel insights on the biophysical effects on various tissues, important to understand the treatment effect, and integrate this knowledge in optimal device (needle) design and multi-physics models for treatment outcome prediction and inverse planning algorithms. Furthermore, the developed assets will be integrated in clinical prototype software to support and optimize the clinical workflow.

Keywords: electroporation,electroporation device,minimally invasive therapies,cancer treatment,predictive treatment models,multi physics models,inverse planning,workflow optimization
OlfSwitch: Neural circuit switches from molecules to behaviour (OlfSwitch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-12-31
Duration (months): 78.0
Total project cost (EUR): 1990791.0
EU funding (EUR): 1293070.0
Participants: 3
Project status: SIGNED

This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic circuit switch that we have recently characterised (for the first time in any animal). We have shown that a transcription factor, fruitless, determines the state of this switch in sex pheromone processing during development. We will now (1) identify the molecules that determine the layout of this specific circuit during development and (2) probe the behavioural relevance of this specific circuit switch. In parallel with this work on pheromone processing, we will examine (3) the circuit basis of valence (simply put whether an odour is attractive or aversive) in which genetic instructions likely hardwire olfactory pathways to downstream modules of different behavioural significance. Finally we will examine the logic of dynamic switches in which a second stimulus (4) positively or (5) negatively gates the response to a stimulus.

Keywords: neural circuits,behaviour,olfaction,thermo,optogenetics,single cell rnaseq,in vivo physiology
Investigating human neuronal transplantation integration and interaction at the single cell level (NeurTransHet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-12-06
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

NeurTransHet will shed light on the heterogeneity of neuronal transplantations and the relationship with their environment. The aim of this project is to bring neuronal transplantation closer to clinical implementation by understanding the intricacies of individual transplanted cell contribution, and later applying this knowledge to engineer them. Neuronal loss underlies various brain disorders, such as Alzheimer’s disease, and injuries, such as traumatic brain injuries, resulting in life-long impairment. For example, dementia, a widespread (a new case every 3 seconds worldwide) condition stemming from neuronal loss, has devastating effects on the patients, their families and their communities. Thus, approaches aiming at replacing the lost neurons by transplantation are not only attractive from a health perspective, but also from a socio-economic standpoint. Many studies have explored neuronal transplantation, albeit with varying degrees of success. This is due to a lack in our understanding of how transplants integrate and interact with their host environment. Additionally, several studies gave evidence that transplanted cells are a heterogenous population, however, so far this heterogeneity has not been addressed in terms of function on integration and interaction. The recent advent of single cell transcriptomic technology, coupled with imaging techniques providing high-resolution spatial information, makes it possible to go beyond global interaction and closely dissect the individual neuronal transplants and their environment. Moreover, the possibility of transplanting cells of human origin in mice increases the clinical relevance of the results. During this two-year fellowship under the supervision of Prof. Dr. Magdalena Götz, who is a world-renowned scientist in neuronal cell replacement methodologies, I will transition into an independent research group leader investigating the role of cell heterogeneity in disease.

Keywords: neural transplantation,human induced pluripotent stem cells,traumatic brain injury,neural cell therapy,single cell investigation
BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal (BlueBio4Future)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2494032.5
EU funding (EUR): 2494032.5
Participants: 1
Project status: SIGNED

Marine Biotechnology (MB) was identified by the EU Blue Growth Strategy (2012) as an enabling activity of high potential for the bioeconomy of Europe. Many products from marine biotechnology are already used in global markets for food and feed, cosmetics, aquaculture, agriculture, chemistry and pharmacology. Nevertheless, the potential for new products development is huge since marine biodiversity and in special, the marine microbiome, is far from being known and exploited. For that purpose, the aspects of Bioengineering - bioprocesses, synthetic biology, green chemistry and bioinformatics - are fundamental. BlueBio4Future aims to enhance CIIMAR research excellence in MB area, in special Bioengineering, contributing to increase attractiveness for outstanding researchers and to establish a long-term impact at regional, national and European levels. The ERA Chair holder will establish a high-performing team in MB at CIIMAR, contributing to increase the knowledge and competitiveness of CIIMAR in the area of MB. This will be done by attracting funds at national and international level, by the supervision of MSc and PhD students, producing high-ranked research outputs, protecting intellectual property and transferring knowledge to stakeholders and contributing to increase literacy in MB. In order to produce structural changes at CIIMAR in the area of MB, there is a need to attract outstanding researchers in the field of Bioengineering that could implement the framework for strengthening a long-term research and innovation enabling environment in the area of MB. The establishment of the ERA CHAIR BlueBio4Future will increase the levels of the research activity in the area of bioengineering in CIIMAR, enhance the capability of the CIIMAR to succeed in competitive research funding, contribute to RIS3 strategies and increased interaction with main actors of the innovation ecosystem and will promote institutional changes to comply with ERA priorities.

Keywords: blue biotechnology,bioengineering,bioprocesses,synthetic biology,green chemistry,bioinformatics
Artificial Intelligence Aided D-band Network for 5G Long Term Evolution (ARIADNE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Finland,Finland,Greece,Greece,Greece,France,France
Call: 5G Long Term Evolution (H2020-ICT-2019-2, 2019)
Start date: 2019-11-01
End date: 2023-07-31
Duration (months): 45.0
Total project cost (EUR): 5968393.75
EU funding (EUR): 5968393.75
Participants: 13
Project status: SIGNED

The ARIADNE project plans to bring together a novel high frequency advanced radio architecture and an Artificial Intelligence (AI) network processing and management approach into a new type of intelligent communications system Beyond 5G. The new intelligent system approach is necessary because the scale and complexity of the new radio attributes in the new frequency ranges cannot be optimally operated using traditional network management approaches. The ARIADNE project will enable efficient high-bandwidth wireless communications by developing three complementary but critical new technologies for Beyond 5G networks in an integrated and innovative way: ARIADNE will develop new radio technologies for communications using the above 100Ghz D-Band frequency ranges, (Pillar 1) ARIDANE will exploit the opportunities emerging for advanced connectivity based on metasurfaces where objects in the environment can become tuneable reflectors for shaping the propagation environment in D-band. (Pillar 2) ARIDANE will employ Machine Learning and Artificial Intelligence techniques to management necessary for the high-frequency communications and dynamic assignment and reconfiguration of the metasurfaces to provide continuous reliable High Bandwidth connections in the Beyond 5G scenario. (Pillar 3)

Keywords: artificial intelligence,machine learning,d band communications
TCBL – Textile and Clothing Business Labs Transformative Business Models for the Textile Clothing Sector (TCBL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: New sustainable business models
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Italy,Italy,Italy,Greece,Romania,Greece,Belgium,Slovenia,Belgium,France,Netherlands,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Business models with new supply chains for sustainable customer-driven small series production (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 8214760.45
EU funding (EUR): 7741697.63
Participants: 25
Project status: CLOSED

TCBL uses Europe’s Textiles & Clothing (T&C) industry as test beds for evolutionary-driven co-design, dynamic optimisation and deployment of business models. It aims to increase the performance of a sector that, over the past two decades, upheld three main strategies to handle global competitive pressure: cost-oriented, product/service-oriented and productivity-oriented. TCBL provides a business experimentation framework for exploring variations on such strategies. The framework will be supported by Knowledge Spaces as a generative force and Business Services as an enabling force. A network of Business Labs will be set up, based on three key variations: Design Labs (e.g. creating emotionally-oriented immaterial value), Making Labs (e.g. converting skilled labour into material value), and Place Labs (e.g. generating spatial community- and socially- oriented value). Each of these Labs will explore the issues of cost, product/service and productivity enhancement in a transversal manner and from cross-disciplinary perspectives - including economic, anthropological, and engineering approaches as well as new business values such as environmental and social responsibility, sharing economy, social enterprising, customer-driven small series production (the focus of this call) and emergent or disruptive technologies. With these tools, and supported by an open Associates Programme, TCBL will carry out real-life experimentation and market deployment of a number of Supply Chain, Localisation, Business, Skill Management and Policy innovations involving no fewer than 160 workshops, laboratories and manufacturing plants at EU level with at least 15,000 T&C workers involved. In addition, 10 new innovative companies will be generated within the supply chain of T&C, enabling the diffusion and scaling up of results. By so doing, a knowledge based, transformational ecosystem will be developed, integrated into an open, yet structured platform environment.

Keywords: textile and clothing,business models,innovation,business labs