Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Photonic-Nano Technologies for Bioapplications (IPN-Bio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Argentina,Finland,China,United States,United Kingdom,United Kingdom,Costa Rica,Peru,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-03-01
End date: 2025-08-31
Duration (months): 66.0
Total project cost (EUR): 1002800.0
EU funding (EUR): 818800.0
Participants: 14
Project status: SIGNED

IPN-Bio (Integrated Photonic-Nano Technologies for Bio-applications) aims to foster and develop long-term international, interdisciplinary and inter-sectoral collaboration between Europe, USA, Latin America and China. IPN-Bio consortium consists of 13 world-leading organisations from eight countries (4 EU universities, 3 EU companies, 6 TC Partner organisations) working at the frontier of the field with the complementary expertise in the multidiscipline of Photonics, Nanotechnology and Biotechnology. IPN-Bio will implement strategies of excellence science through a total of 218 person-month of structured international and inter-sectoral staff exchanges involving 36 individual researchers. The R&I staff exchanges and network activities will provide an excellent platform for the exchanged researchers to share the knowledge and ideas, transfer the skills and boost career opportunities. The project’s objectives and challenges present a balanced mix between industrial application focused knowledge transfer and development and more far-looking studies for potentially ground-breaking applications by exploiting new emerging opportunities with the integration of photonics technology and advanced nanomaterials for the applications in health care, biomedical diagnosis, food safety and environmental monitoring. The IPN-Bio network will forge strong collaborative relationships between participating organisations, push Europe at the forefront of global biophotonics research community, and strengthen Europe’s human capital, competitiveness and economy growth.

Keywords: photonics,biosensor,fiber sensor,optical biosensor,biophotonics,nanomaterials
STARTS Prize 2021-2023 (STARTS Prize)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,Italy,Austria,Belgium,France,Netherlands,Portugal
Call: Next Generation Media (H2020-ICT-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1999812.5
EU funding (EUR): 1999812.5
Participants: 7
Project status: SIGNED

S+T+ARTS=STARTS – Innovation at the Nexus of Science, Technology, and the ARTS: STARTS is an initiative of the European Commission to foster alliances of technology and artistic practice that effectively implement European policymaking to nurture innovation and that showcase the role of artists and designers in these practises. The focus is on people and projects that contribute to mastering the social, ecological and economic challenges this continent faces. One element of this STARTS Initiative is a prestigious award generously endowed with €40,000 in prize money. A yearly competition is held to single out for recognition innovative projects at the nexus of science, technology and the arts that have what it takes to make a significant impact on economic and social innovation. The two STARTS prizewinners each receive €20,000 and are prominently featured at Ars Electronica, BOZAR, Frankfurt Book Fair and many dissemination partners around the world.To bring the STARTS Prize to a new level, the consortium extended the partnership and expands the project’s objectives in the following directions: - Foster the growth and dynamic connectivity of STARTS to other international programs by community engagement and building a collaborative framework - Introduce a new, additional STARTS Prize call priority in the novel creation, access & distribution of media content and development of new, qualitative approaches as a result of disrupting traditional media - Build an evaluation framework to sensibly extract and map success indicators and impacts generated from the STARTS Prize winners - Learn from this assessment for structured, sustainable recommendations for EU and national policy makers as well as the media industry - Increase the dissemination activities in the media sector by involving actors such as Buchmesse and strong media partnerships

Keywords: arts,design,science,research,media,interdisciplinary,innovation
Relocating Care within Europe: Moving the elderly to places where care is more affordable (ReloCare)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499978.0
EU funding (EUR): 1499978.0
Participants: 1
Project status: SIGNED

Within care studies, the transnationalization of care has been mainly understood as drawing on (female) migrant care workers and resulting in a ‘care gap’ in the places such workers leave behind. This project looks at the reverse phenomenon: care relocation, in which the ageing body is relocated to places where care is more affordable. This hotly contested trend, described as ‘grandmother deportation’ or ‘geriatric colonialism’, can be seen as an extreme example of the marketization of care, and entangling welfare states as entitlements are carried across national borders within Europe. This multi-sited anthropological study will take as case studies care homes in Central Eastern Europe (Poland, Czech Republic, Slovakia, and Hungary) that recruit patients from Austria and Germany, and offer care at roughly one-third of the cost of similar institutions in the home countries. What does care relocation do to the people and places involved? Most of these care homes are located in regions characterized by a long German and Habsburg-Hungarian history, adding historical complexity to the story. Some serve only German-speaking patients, others serve local, wealthier elderly people as well. They are run by former migrant care workers and by international companies, bringing labour migration and real estate investment into the picture. ReloCare breaks new ground by encompassing all of these aspects in one study. Alongside in-depth ethnographic studies of daily life in these care homes, the researchers will investigate the nexus of care entrepreneurs and state insurances, and the histories of places and regional migration, providing an understanding of these new transnational entanglements of welfare states. In perceiving care relocation as both part of future making and a response to the privatization of care landscapes in the region, it asks what it means to become old and in need of care in an increasingly intertwined Europe.

Keywords: anthropology of care,anthropology of the state,medical anthropology,transnational care landscapes,migration infrastructure,care tourism,political subjectivity,care ethics,care chains,history,human geography,europe
INnovative chemIcal sensors for enanTioselective detectIon of chiral pOllutants (INITIO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Estonia,Ireland,Italy,Italy,Estonia,Italy,Finland,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 2929901.25
EU funding (EUR): 2929901.25
Participants: 10
Project status: CLOSED

Chiral pollution is an environmental topic of crucial importance, considering that a large number of chemicals spreading into the environment, for example pesticides, are chiral substances. However, usually the stereoisomerism of contaminants is not considered, although the biological activity of enantiomers is significantly different, making their recognition critical for environmental control. Enantiomeric excess is currently determined by off-site analysis, requiring collection, transportation, eventual pre-treating of the sample, and expensive instrumentations and specifically trained staff. Thus, providing devices able to allow for rapid on site detection and chiral discrimination of target analytes would have a dramatic impact in all the fields of environmental control with significant economic benefits. The development of chemical sensors has been conceived to bypass restrictions related to classical analytical protocols and supports the use of conventional laboratory techniques for environmental control. While the technological foundation for chemical sensors already exists, it has been difficult to apply them to chiral discrimination and analysis, due to the lack of suitable solid state receptors. The main aims of the project are: a) the development of novel molecular receptors, mainly based on porphyrin derivatives, b) integration of the receptors with different nanostructures and characterization of their solid state organization, c) deposition of the structures onto transducer surfaces, d) testing and validation of the new chemical sensor devices with enantiomeric pairs of model analytes. The synergistic complementary know-how of six academic units and two private companies will allow a breakthrough development through delivery of sensing probes ranging from the synthesis of macrocyclic molecular receptors to the building and testing of analytical and electronic parts for final, field-capable devices.

Keywords: chemical sensors,porphyrinoids,chiral discrimination,chiral pollutants
Preventing EU Youth Unemployment - One Gig at a Time (WorkPilots expansion)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Work Pilots Oy runs the service WorkPilots, which is a SaaS-based mobile-first on-demand job matching platform / service to provide 1) valuable practical work experience to those who need help to get into worklife, 2) easy way of hiring people for small on-demand tasks and 3) new models and innovative co-creation opportunities for municipalities and other stakeholders whose task is to help youth and solve youth unemployment. WorkPilots was launched in Finland with an iOS, Android and web version of the service in February 2016 with focus on young people. It is currently focusing on accumulating more workers and paying customers through scalable concepts and co-creation models with e.g. educational institutions, municipalities, NGO's and organizations (particularly those who value Corporate Responsibility). The service is operating in over 60 cities in Finland and has already attracted over 25,000 users and generated lots of good experiences how to create social impact. We feel that Our service is uniquely placed to help solve a major problem in almost all European countries - how to integrate young and other disenfranchised people into society and open low threshold paths to worklife. Key features that we have developed that directly help target this issue are: 1. Co-creation within partnerships and boosting the work done in local ecosystems 2. Differentiating by enabling a socially responsible model e.g. being a platform where not only the best performers get opportunities – but instead the more challenged youth get their opportunities as well and thus path to next steps, 3. Creating reliable technology supporting on-demand job matching, and 4. Easy models for organisations to find current and future workforce – with social responsibility in focus and workers to find work opportunities. The goal of the Phase 1 Feasibility Study is to develop a thorough business plan for European market uptake.

Keywords: gigeconomy,platform,mobility,work,worklife,unemployment,young,social inclusion,co creation,partnership,social impact
Functionalisation of ultra-bright all organic nanoparticles for super resolution imaging in intact brain preparations (NanoFUNC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-04-23
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Nanotechnologies have the potential to revolutionise our understanding of devastating diseases such as cancer or neuropathologies. By combining light-emitting nanoparticles (NPs) and super-resolution imaging, it is possible to observe living tissues at the molecular scale, resulting in images of unprecedented detail. To this aim, the ideal NP should be bright, stable, small, spectrally relevant, versatile, targetable, and non-toxic. These features have been sought after by chemists, physicists and biologists alike for more than a decade but their presence in a single NP has not been achieved to date. The objective of the NanoFUNC project is thus to develop the next generation of NPs displaying all the above properties. We propose to achieve this by conferring targeting properties to the latest all organic NPs of the host laboratory already displaying promising spectral characteristics. We will first validate the functionalisation of these new tools on model cellular systems before applying them to track neurotransmitter receptors deep in intact brain slices of healthy and schizophrenia rat models. We expect this project to impact all communities benefiting from advances in bioimaging including neuroscience, medicine and cell biology as a whole. We thus envisage to patent the obtained NPs for use in marketable bioimaging applications. The transfer of knowledge between the expertise of the host in nanochemistry and that of the experienced researcher in neurobiology provides a unique opportunity to successfully complete this highly interdisciplinary project. Moreover, the mobility of the researcher back to France in an internationally renowned laboratory is sure to enhance her career prospects as she aims to become an independent researcher in the near future. Together, the host and the researcher will strive for excellent scientific results and build a career plan involving training, management and communication to bring the researcher to full professional maturity.

Keywords: single particle tracking
A SiPM upgrade for VHE Astronomy and beyond (Light-Trap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Ground-based gamma-ray astronomy in the Very High Energy (VHE, E>100 GeV) regime has fast become one of the most interesting and productive sub-fields of astrophysics today. Utilizing the Imaging Atmospheric Cherenkov Technique (IACT) to reconstruct the energy and direction of incoming gamma-ray photons from the universe, several source-classes have been uncovered by previous and current generations of IACT telescopes (e.g. Whipple, MAGIC, HESS, VERITAS). The next generation IACT experiment, the Cherenkov Telescope Array (CTA) will provide increased sensitivity across a wider energy range and with better angular resolution. However, research into new and improved technology for potential upgrades of the CTA system are already being considered. Improving the light-collection efficiency (hence reducing the energy threshold) and field-of-view of CTA cameras is high on the agenda of future upgrades. One may also consider increasing the number of telescopes if the cost of the cameras could be significantly reduced. The primary path to these goals is to replace PhotoMultipliers (PMTs) with Silicon-PMs (SiPM). These new photodetectors will also find multi-disciplinary use in e.g. in fluorescence telescopes for detection of Ultra High Energy Cosmic Rays and PET scanners in medical physics. However SiPMs are not yet mature enough to replace PMTs for several reasons: sensitivity to unwanted longer wavelengths while lacking sensitivity at short wavelengths, small physical area, high cost and electronic noise. Here we propose a novel method to build relatively low-cost SiPM-based pixels utilizing wavelength-shifting material which overcome some of these drawbacks by collecting light over a larger area than standard SiPMs and improving sensitivity to shorter wavelengths while reducing background. We aim to optimize the design of such pixels, integrating them in an actual 7-pixel cluster which will be inserted into a MAGIC camera and tested during real observations.

Keywords: silicon pms,light trap,vhe astronomy,cherenkov radiation
Cell-Based Models for Neurodegeneration Study and Use in Screening (CENSUS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Sweden,France,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 2561828.75
EU funding (EUR): 1793280.13
Participants: 4
Project status: CLOSED

1. Treatment of neurodegenerative disease is an unmet clinical challenge and patient care is a growing, unsustainable global healthcare burden. The project will produce novel tools to address this challenge. 2. The consortium will deliver a set of innovative analytical tools for neurodegenerative drug discovery using a combination of stem cell biology and novel biomaterials assembled by additive manufacturing. 3. The toolset will be analytical kits containing induced pluripotent stem cell (iPSC)-derived human neural cells in 3D culture formats, delivered to end-users in multiwell plates ready for industrial screening. 4. Project outputs will be realised by an inter-disciplinary consortium of four SME commercial partners in three European countries, each partner supplying a specific, essential skillset. 5. iPSC-derived neural cells will be produced by Phenocell sarl (F) using stem cell differentiation protocols already shown to generate glial or neuronal cell lineages, and to reinstate donor disease phenotypes. 6. Bio-printer instrumentation and printable bio-inks to manufacture 3D scaffolds enabling 3D cell culture will be contributed by Cellink (SE). 7. 3D culture models will be customised for neural/neurodegenerative cell culture by inclusion of peptide dendrons with biological functionality using mature chemistry proprietary to Tissue Click Ltd (UK). 8. Cell-based analysis products will be validated, and made user-friendly by in situ cell cryopreservation and analytical processes familiar to AvantiCell Science Ltd (UK). 9. Each contributing technology is at TRL 6, and each has commercial utility in simpler combinations. The project assembles them in first-to-market formats beyond the current state of the art. 10. The CENSUS project output, comprising iPSC-derived neural cells cryopreserved in single-cell and co-culture 3D formats will deliver exceptional analytical precision and predictive value, unprecedented end-user convenience and strong commercial advantage

Keywords: bioprinting,3d cell culture,bioligands,cell cryopreservation
Early clinical development of a live, attenuated combination vaccine against Shigella and ETEC diarrhoea (SHIGETECVAX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Sweden,United States,Bangladesh
Call: New anti-infective agents for prevention and/or treatment of neglected infectious diseases (NID) (H2020-SC1-2018-Two-Stage-RTD, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 10757304.91
EU funding (EUR): 8603989.93
Participants: 6
Project status: SIGNED

Although vaccination is an effective way to reduce the huge disease burden associated with diarrhoea caused by enteric pathogens, many attempts to develop vaccines for shigellosis and ETEC infections have failed and a number of current approaches are too complex and costly to provide an adequate solution for LMICs. This Consortium is dedicated to advancing a radically new approach against Shigella and ETEC based not on the immunodominant, but highly variable Shigella LPS O-antigen, target of almost all past and current vaccine development efforts. There are four pillars on which the ShigETEC vaccine has been designed: (i) Elimination of the LPS O-antigen to allow recognition of multiple antigens on the cell surface that are shared among different serotypes of Shigella and are increasingly being recognized as important in protection from shigellosis. These antigens are also closely related to those of ETEC and may also help in protecting against that pathogen as well. (ii) Elimination of the invasiveness of Shigella by disruption of the invasion complex resulting in a much safer/less reactogenic oral vaccine that can take advantage of gut mucosal immunity, possibly allowing administration of high vaccine doses and therefore addresses the low immunogenicity seen with other live attenuated vaccine candidates. (iii) Addition of detoxified toxin antigens of ETEC that will induce neutralizing/blocking antibodies to these critical virulence factors. (iv) Rational molecular design of ShigETEC will allow future generations of vaccines to include additional antigens for other pathogens. The work programme entails manufacture of clinical trial material, first-in-human testing for safety and immunogenicity in non-endemic adults, a sero-epidemiology study to learn about natural immune response to the vaccine, and importantly testing the vaccine in endemic populations. The Consortium comprises partners from EU and Bangladesh that bring along highly complementary expertise.

Keywords: shigella,etec,vaccine,clinical development,clinical trial