Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic and physiological basis of thinness (STILTS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: CLOSED

The rising prevalence of obesity and associated co-morbidities such as Type 2 diabetes, cardiovascular disease and certain cancers represents a major threat to public health in Europe and worldwide. It can be argued that modern westernized environments are obesity promoting due to unprecedented economic growth, decreased incidence of infectious disease, nearly unlimited food supply, a wide availability of high fat, highly palatable pre-prepared foods, large portion sizes and technological advances leading to a more sedentary lifestyles. The influence on the whole population of environmental factors is undoubtedly powerful, but one remarkable feature of the obesity epidemic is the persistence of enormous individual variation in body weight throughout the population. Individual differences seem to be increasing in both children and adults, with the lean staying lean while the obese become more obese, which indicates that individuals interact differently with the ‘obesogenic’ environment. There is strong evidence that within a population the variance in weight is largely genetically determined. Given that common obesity results from an imbalance between energy intake and expenditure, it is highly likely that this interaction occurs partly through individual variation in appetite and eating behaviours. To date virtually all research based at finding genes related to obesity has focussed on the upper end of the body mass index (BMI) distribution. As part of this proposal I propose a complementary gene finding strategy that focuses on the lowest end of the BMI distribution in order to find genes that confer resistance to obesity in an obesogenic society. The identification of such genes may explain why some individuals do not become obese despite environmental provocation. Insights into the biology of thinness and obesity resistance could lead to rational preventative and therapeutic strategies for obesity.

Keywords: obesity
Multilateral Association for Studying health inequalities and enhancing north-south and south-south COoperaTion (MASCOT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Coordination and support actions
Countries involved: Switzerland,France,Portugal,Mexico,Chile,South Africa,Tanzania, United Republic of,Ghana,United Kingdom,Tunisia,Costa Rica
Call:  (FP7-HEALTH-2011-single-stage, 2011)
Start date: 2011-10-01
End date: 2014-03-31
Duration (months): 30.0
Total project cost (EUR): 2289335.2
EU funding (EUR): 1999895.0
Participants: 11
Project status: CLOSED

Inequalities and vulnerable groups’ health, as well as the slow advances to achieve the health- related Millennium Development Goals, are concerns that need to be addressed, notably for low and middle-income countries. While some countries have made advances, these remain unknown to other ones which could still benefit from their experience. Higher collaboration could help but is quite difficult to achieve. The MASCOT project gathers therefore 11 partners from 3 geographical areas (Europe, Latin America & Africa), an advisory board and additional relevant experts to answer this problematic. The work is specifically designed to achieve defined objectives: - to create links between North-South and South-South efforts in addressing maternal and child health and health inequalities (MCH&I) in developing countries - to provide evidence on best practice and policy advice for the development of future public health and health systems interventions. Following a first step of standardisation and quality control procedures, the project will implement mapping activities in individual countries of the 3 regions of interest in order to assess the current situation of MCH inequalities, to identify institutions and research teams performing research in this area, to detect promising projects and research results as well as strategies, programs and policies implemented to tackle MCH inequalities. This will result in recommendations of best practices and policy advice to countries willing to implement actions to improve MCH&I. An important part of the work will also stimulate multi-lateral collaboration and knowledge transfer as a key activity of MASCOT. All along the project, different tools such as meetings, workshops, partnering event, website, and brochures will be used to communicate and promote the exchange between health stakeholders and policy-makers. Ultimately MASCOT should thus allow reducing gaps in health inequalities between and within different regions of the world.

Keywords: maternal and child health,health inequalities,health research systems,best practice,policy advice,knowledge transfer,cooperation,north-south,south-south,africa,latin america,europe
Development of an innovative paediatric formulation of an antiepileptic agent for the treatment of absence epilepsy in children. (KIEKIDS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: France,France,Switzerland,Belgium
Call:  (FP7-HEALTH-2011-single-stage, 2011)
Start date: 2011-10-01
End date: 2017-03-31
Duration (months): 66.0
Total project cost (EUR): 2839400.2
EU funding (EUR): 2157071.0
Participants: 4
Project status: CLOSED

The KIEKIDS project is dedicated to the development of an innovative paediatric formulation of an antiepileptic agent for a safe alternative treatment of absence epilepsy in children. Development of such an age-appropriate formulation is regarded by The European Medicines Agency (EMA) to be amongst one of highest priorities for the treatment of absence seizures, using a drug with identified and documented efficacy in the target population. The KIEKIDS project has gathered a very strong consortium of well trained and qualified partners from industry, academy, and hospital with extensive experience in drug development in clinical, pharmacological, data analysis and regulatory areas. The proposed strategy for KIEKIDS implies to develop a dedicated paediatric formulation with sustained delivery and to conduct a clinical programme, which will be endorsed by approval of the Paediatric Investigation Plan (PIP). The consortium is coordinated by the Unit 663 of INSERM (INSERM U663), a French public organisation of research devoted to the paediatric epilepsies and brain plasticity. This consortium rallies all the competencies required to manage a paediatric drug development from the designing of an adapted formulation up to market. With its solid track record of clinical success in pharmaceutical and biotech companies, and its huge expertise in absence epilepsy, this consortium will be able to avoid the pitfalls of pharmaceutical drug development and is in a strong position to guarantee the success of the programme. The ultimate goal of KIEKIDS is to submit in 2015 this novel age-adapted paediatric formulation as a Paediatric-Use Marketing Authorisation, a PUMA, the tool identified by the EMA to bridge the gap for off-patent drugs.

Keywords: epilepsy,paediatric formulation
Earth system Model Bias Reduction and assessing Abrupt Climate change (EMBRACE)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Collaborative project
Countries involved: Sweden,Netherlands,United Kingdom,Sweden,Germany,Germany,Finland,Switzerland,United Kingdom,United Kingdom,Belgium,France,United Kingdom,Netherlands,Croatia,Netherlands,Germany
Call:  (FP7-ENV-2011, 2011)
Start date: 2011-11-01
End date: 2016-02-29
Duration (months): 52.0
Total project cost (EUR): 9530409.2
EU funding (EUR): 6999730.2
Participants: 20
Project status: CLOSED

EMBRACE brings together the leading Earth System Models (ESMs) in Europe around a common set of objectives to improve our ability to (i) simulate the Earth System and (ii) make reliable projections of future global change. EMBRACE builds on the existing European collaboration network in Earth System Modelling and will be the main European input to international efforts in this field over the coming 5 years. The project has a number of key goals; (i) to reduce the main, known biases in existing European ESMs, (ii) to fully evaluate ESM simulation capabilities and improvements made in the project, (iii) to increase the realism of, and interactions between, the physical and biogeochemical components of ESMs, (iv) to assess the risks of abrupt or irreversible changes in key components of the Earth system, in response to the most recent greenhouse gas, aerosol and land-use scenarios proposed for the IPCC AR5. The primary ESM biases targeted for improvement include, (i) the representation of moist atmospheric convection and links to coupled tropical variability and precipitation. (ii) equatorial and coastal ocean upwelling and their impact on the global climate system and carbon cycle, (iii) coupled processes controlling physical and biogeochemical mixing in the Southern ocean, (iv) soil hydrology and its coupling with the atmosphere and (v) the terrestrial carbon cycle, through a more realistic treatment of climate-vegetation interaction. Improvements will be evaluated in the context of the full range of CMIP5 historical simulations, with the CMIP5 protocol forming the basis for future climate projections made to assess the risk of abrupt changes. A cross-cutting theme will be the impact of improved process description, combined with increased coupled model resolution, in reducing ESM biases and improving their reliability of future projections.

Keywords: earth sytem modelling,climate change,uncertainties,bias
High temperature thermal energy Storage by Reversible thermochemical Reaction (STORRE)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: France,France,Greece,Spain,Spain,Italy
Call:  (FP7-ENERGY-2011-1, 2011)
Start date: 2012-09-01
End date: 2016-06-30
Duration (months): 46.0
Total project cost (EUR): 2917017.0
EU funding (EUR): 2204501.6
Participants: 7
Project status: CLOSED

StoRRe proposal concerns the area of thermal energy storage by chemical reaction for concentrated solar power plants (CSP). The objective of the project is to develop a new and promising solution for the heat storage with the following characteristics:  Mid-term (24h to few days) up to long-term (several months) heat storage  High storage density (300-500 kWh∙m3),  High temperatures (300-550°C), which are representative of the CSP plants with cylinder-parabolic or CLFR technologies. The objective of the StoRRe project is to develop and quantify, at a pilot scale, the interest of a thermochemical storage solution with the dehydration of Ca(OH)2, and to study the development opportunity at the pre-industrial scale. The consortium is composed of a major industrial manufacturer involved in the CSP business, a SME developping innovative solar and biomass technologies and three research centres.

Keywords: thermal energy storage concentrated solar power plants chemical reaction
Consolidating Empire: Reconstructing Hegemonic Practices of the Middle Assyrian Empire at the Late Bronze Age Fortified Estate of Tell Sabi Abyad, Syria, ca. 1230 – 1180 BC (CONSOLIDATING EMPIRE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: The study of the human past
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101124, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 1191127.2
EU funding (EUR): 1191127.2
Participants: 1
Project status: CLOSED

The origins of imperialism, a socio-military system in which hegemony is achieved over alien territories, are poorly investigated. This applies in particular to how imperial strategies affected local communities. This project will investigate the hegemonic practices of one of the earliest stable empires: that of the Assyrians, by focussing on the Late Bronze Age fortified estate at Tell Sabi Abyad, ca. 1230-1180 BC. The Assyrians created a network of strongholds in conquered territories to consolidate their hegemony. The fortified estate at Tell Sabi Abyad is the only extensively investigated of these Assyrian settlements. This settlement is both small and well preserved and has been completely excavated. The complete plan facilitates a study of the spatial properties of this fortress and how it structured interactions. Further, the estate contained a wealth of in situ finds, which allow for a reconstruction of activity patterns in the settlement. Finally, over 400 cuneiform tablets were found which shed light on the local social and economic situation and the broader imperial context. This project will provide a bottom up perspective on the Assyrian Empire. Elements of the Tell Sabi Abyad estate that will be investigated include: spatial characteristics; activity areas; the agricultural economy; and the surrounding landscape. Further, data from the Middle Assyrian Empire at large will be reconsidered, in order to achieve a better understanding of how this empire was constituted. This project is innovative because: it investigates a spatial continuum ranging from room to empire; brings together types of data usually investigated in isolation, such as texts and artifacts; will involve the use of novel techniques; and will investigate the short term normally beyond the scope of archaeology. The research will contribute to the cross-cultural issue of how hegemonic control is achieved in alien territories, and add to our understanding of early empires.

Keywords: origins of imperialism,assyrian empire,constitution of empire,fortified estate,spatial analysis,landscape reconstruction,agricultural economy and craft production,syria,late bronze age
New Materials and Control for a next generation of compact combined Solar and heat pump systems with boosted energetic and exergetic performance (MACSHEEP)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewables for heating and cooling
Action type: Collaborative project
Countries involved: Switzerland,Sweden,France,Czechia,Austria,France,Germany
Call:  (FP7-ENERGY-2011-1, 2011)
Start date: 2012-01-02
End date: 2016-01-01
Duration (months): 48.0
Total project cost (EUR): 3088642.2
EU funding (EUR): 2259013.85
Participants: 9
Project status: CLOSED

The objective of this project is to develop new innovative products and advanced test methods for a next generation of compact combined renewable energy systems based on solar thermal and heat pump technology for space heating and hot water preparation, using breakthroughs in ICT, new materials and technology. The goal is to achieve 25% energy savings compared to current state of the art systems, with still competitive prices on the market. Thus, the work proposed aims for a seasonal performance factor of the system (solar and heat pump) of e.g. 6 as compared to 4.5 for the current state of the art. This will be possible by using new materials, components and ICT in an integrative approach for new system concepts where the focus is on the overall system's cost and performance. A systematic approach will be used to evaluate new breakthroughs such as e.g. low-cost materials and selective paint for solar collectors that collect solar irradiation as well as ambient heat and PV/T collectors that produce heat as well as electricity. Exergetic optimization of heat pump circuits includes using de-superheating heat exchangers for DHW preparation as a by-product of the more efficient space heating operation, and variable speed controlled compressors for heat pumps that match the collector heat input to the evaporator and/or the demand. New storage concepts include phase change materials (PCM) on the cold side of the heat pump, low cost materials for storage tank construction, improved temperature stratification and charging/discharging control. On the control and ICT side, weather and user forecast based predictive control for intelligent storage charging by different heat sources will help to increase the overall system performance significantly. Online monitoring and fault detection within small controller units will be used to increase system reliability both for the installation phase and for the whole operational life of the installation.

Keywords: combined renewable energy systems,solar thermal,heat pumps,development,testing,performance,space heating,domestic hot water
Production of Solid Sustainable Energy Carriers from Biomass by Means of Torrefaction (SECTOR)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: Germany,Finland,Netherlands,Denmark,United Kingdom,Germany,Austria,Sweden,Spain,Sweden,United Kingdom,Poland,Germany,Austria,Netherlands,Germany,Netherlands
Call:  (FP7-ENERGY-2011-1, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 10222685.11
EU funding (EUR): 7565725.0
Participants: 22
Project status: CLOSED

Torrefaction is considered worldwide as a promising key technology for boosting large-scale implementation of bioenergy. It involves heating biomass in the absence of oxygen to a temperature of 200 to 320 °C. As a result, the biomass looses all its moisture and becomes easy to grind and water resistant, which reduces the risk of spontaneous ignition and biological degradation and permits outdoor storage. By combining torrefaction with pelletisation or briquetting, biomass is converted into a high-energy-density commodity solid fuel or bioenergy carrier with superior properties in view of (long-distance) transport, handling and storage, and also in many major end-use applications (e.g., co-firing in pulverised-coal fired power plants, (co-)gasification in entrained-flow gasifiers and combustion in distributed pellet boilers. Moreover, torrefaction-based bioenergy carriers may form a good starting point for biorefinery routes. The current SECTOR project is focussed on the further development of torrefaction-based technologies for the production of solid bioenergy carriers up to pilot-plant scale and beyond and on supporting market introduction of torrefaction-based bioenergy carriers as a commodity renewable solid fuel. The core of the project concerns the further development of torrefaction and densification technology for a broad biomass feedstock range including clean woody biomass, forestry residues, agro-residues and imported biomass. Production recipes will be optimised on the basis of extensive logistics and end-use testing. Much attention will be given to the development, quality assurance and standardisation of dedicated analysis and test methods. The experimental work will be accompanied by extensive desk studies to define major biomass-to-end-use value chains, design deployment strategies and scenarios, and conduct a full sustainability assessment. The results will be fed into CEN/ISO working groups and international sustainability forums.

Keywords: torrefaction,torrefied biomass,bioentergy,pellets,densification
Strategies and tools for Real Time EArthquake RisK ReducTion (REAKT)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Collaborative project
Countries involved: Italy,Germany,Switzerland,France,Italy,Greece,Germany,France,Italy,Iceland,United Kingdom,Portugal,Türkiye,Romania,United Kingdom,United States,Jamaica,Taiwan, Province of China,Japan,Trinidad and Tobago
Call:  (FP7-ENV-2011, 2011)
Start date: 2011-09-01
End date: 2014-12-31
Duration (months): 40.0
Total project cost (EUR): 10111177.79
EU funding (EUR): 6972190.0
Participants: 23
Project status: CLOSED

Earthquakes are a serious threat for many European countries, particularly those around the Mediterranean Sea. In many cities exposed to high earthquake hazard, a substantial proportion of the population still lives in buildings that do not meet modern earthquake-resistant standards. Preventive actions, such as retrofitting of structures, are essential, but they are not sufficient and cannot be applied easily on a large scale. Real-time actions focussing on decreasing the physical vulnerability and exposure of populations are a viable way to reduce earthquake risk. The primary objective of REAKT is to improve the efficiency of real-time earthquake risk mitigation methods and their capability of protecting structures, infrastructures and populations. REAKT aims to develop methodologies that will enhance the quality of information provided by earthquake forecasting, early warning and real-time vulnerability systems, as well as establishing best practices for how to use all of this information in a unified manner. In order to be used effectively, such information needs to be combined into a fully probabilistic framework, including realistic estimates of the uncertainties involved, that is suitable for decision making in real time. The REAKT consortium draws together most of the main European institutes and research groups, in addition to major non-European institutes, that are working on different aspects of earthquake early warning and probabilistic models of operational forecasting. The project is divided into 7 scientific work packages that constitute a logical sequence from, at one end, the processes involved in earthquake generation and the physics of short-term seismic changes, to the other, the threatened people. through operational earthquake forecasting, early warning and rapid assessment of damage and vulnerability, decision making and capacity building, and the application of the developed methodologies to 12 strategic test cases.

Keywords: earthquake hazard,vulnerability and risk,earthquake early warning,earthquake operational forecasting