Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building up a brain: understanding how neural stem cell fate and regulation controls nervous tissue architecture (BRAINSTRUCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1929713.0
EU funding (EUR): 1929713.0
Participants: 3
Project status: CLOSED

The brain is an extraordinary complex assembly of neuronal and glial cells that underpins cognitive functions. How adequate numbers of these cells are generated by neural stem cells in embryonic and early postnatal development and how they distribute and interconnect within brain tissue is still debated. In particular, the potentialities of individual neural stem cells, their potential heterogeneity and the mechanisms regulating their function are still poorly characterized in situ; likewise, the clonal architecture of mature brain tissue and its influence on neural circuitry are only partially explored. Deciphering these aspects is essential to link neural circuit development, structure and function, and to understand the aetiology of neurodevelopmental disorders. We have recently established transgenic strategies to simultaneously track the lineage of multiple individual neural stem cells in the intact developing brain and experimentally perturb their development. We will use these approaches in combination with recent large-volume imaging methods for high-throughput analysis of individual neural and glial clones in the mouse cortex. This will allow us to assay neural progenitor potentialities and equivalence, characterize developmental changes occurring in the neurogenic niche, describe the clonal organization of the mature cortex and study its link with neural connectivity. To decipher intrinsic and extrinsic mechanisms regulating neural progenitor activity and understand how they produce appropriate numbers of cells, we will assay the outcome of functional perturbations targeting key steps of neural development, introduced in precursors or in their local environment. These experiments will reveal how neural stem cell output might be regulated by cell interactions and intercellular signals. This multidisciplinary project will set the basis for quantitative analysis of brain development with single-cell resolution in normal and pathological conditions.

Keywords: lineage tracing,genetic engineering,large volume imaging,fluorescence microscopy
TSO-DSO-Consumer INTERFACE aRchitecture to provide innovative grid services for an efficient power system (INTERRFACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Spain,Estonia,Italy,Italy,Cyprus,Belgium,Greece,Bulgaria,Finland,Greece,Hungary,Romania,Finland,Finland,Hungary,Hungary,Romania,Slovenia,Slovenia,Serbia,Belgium,Latvia,Portugal,Luxembourg
Call: TSO – DSO – Consumer: Large-scale demonstrations of innovative grid services through demand response, storage and small-scale (RES) generation (H2020-LC-SC3-2018-ES-SCC, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 20914682.14
EU funding (EUR): 16808962.5
Participants: 51
Project status: CLOSED

With the growth of renewables, the increased interconnection of European grids, the development of local energy initiatives, and the specific requirements on TSO – DSO cooperation as set forth in the different Network Codes and Guidelines, TSOs and DSOs face new challenges that will require greater coordination. The European Commission adopted legislative proposals on the energy market that promote cooperation among network operators as they procure balancing, congestion management and ancillary services. The measures encourage procurement of services at both the transmission and distribution level, recognizing that this will enable more efficient and effective network management, will increase the level of demand response and the capacity of renewable generation. TSOs and DSOs must now define the services they want to procure in collaboration with market participants, and must set up ways to procure them in a coordinated manner. Digitalisation is a key driver for coordination and active system management in the electricity grid, enabling TSOs and DSOs to optimise the use of distributed resources and ensure a cost-effective and secure supply of electricity but also empowers end-users to become active market participants, supporting self-generation and providing demand flexibility. To support the transformation, the INTERRFACE project will design, develop and exploit an Interoperable pan-European Grid Services Architecture to act as the interface between the power system (TSO and DSO) and the customers and allow the seamless and coordinated operation of all stakeholders to use and procure common services. State-of-the-art digital tools based on blockchains and big data management will provide new opportunities for electricity market participation and thus engage consumers into the INTERRFACE proposed market structures that will be designed to exploit Distributed Energy Resources.

Keywords: network codes,pan eu market,operators collaboration,data management,congestion management,wholesale market,grid services
Support to the Vice-Presidents of the ERC Scientific Council 2018 (ERC VP CSA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Denmark
Call: Support to the Vice-Chairs (H2020-IBA-ERC-VPRES-SUP-18, 2018)
Start date: 2018-01-01
End date: 2018-12-31
Duration (months): 12.0
Total project cost (EUR): 249664.0
EU funding (EUR): 249664.0
Participants: 1
Project status: CLOSED

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees the ERC's scientific management and the implementation of its Work Programme. This project aims to support the ERC Vice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2018. This project will provide local administrative and advisory support to the three ERC Vice-Presidents. The staff supported by this project will provide analysis of the output of the ERC and the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment. The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon 2020.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liaison with the erc executive agency
Food, Culture and Identity in Ireland, 1550-1650 (FOODCULT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Ireland,Ireland,United Kingdom,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-07-31
Duration (months): 78.0
Total project cost (EUR): 1433133.0
EU funding (EUR): 905088.04
Participants: 7
Project status: SIGNED

FOODCULT is the first project to establish both the fundamentals of everyday diet, and the cultural ‘meaning’ of food and drink, in early modern Ireland. Exploring the period 1550-1650, one of major economic development, unprecedented intercultural contact, but also of conquest, colonisation and war, it focusses on Ireland as a case-study for understanding the role of food in the demonstration and negotiation of authority and power, and as a site for the development of emergent ‘national’ food cultures. Moving well beyond the colonial narrative of Irish social and economic development, however, it enlarges the study of food to examine neglected themes in Irish historiography, including gender, class, kinship and religious identities, as expressed through the consumption and exchange of food and drink. Taking advantage of recent archaeological discoveries and the unprecedented accessibility of the archaeological evidence, the project develops a ground-breaking interdisciplinary approach, merging micro-historical analytical techniques with science and experimental archaeology, to examine what was eaten, where, why and by whom, at a level of detail deemed impossible for Irish history. Such questions will be explored in a comparative British Isles context, situating Irish developments within a broader analytical framework, whilst moving English food historiography beyond its current insular focus. As a corollary, the project will produce the first major database of diet-related archaeological evidence for this period Mapping Diet: Comparative Food-Ways in Early Modern Ireland, while making accessible the only existing household accounts, a hugely significant, and previously overlooked, quantitative and qualitative source for dietary trends. These resources will shed light, not just on consumption patterns, but on Ireland’s broader economic and social development, whilst significantly furthering research agendas in early modern historical and archaeological scholarship.

Keywords: interdisciplinary approaches to consumption,history and archaeology of food and nutrition
Discovering susceptibility genes to Rhizoctonia solani in rice as breeding targets for sheath blight disease resistance (RiZeSisT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-06-23
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Rice is a main staple food providing more than 50 percent of the world’s calories intake. However, grain yield and quality are drastically reduced by the sheath blight disease (ShBD), the second most important disease. ShBD is caused by the soilborne, necrotrophic fungal pathogen, Rhizoctonia solani. No rice germplasm providing complete resistance is available, preventing improvement of cultivated rice varieties. Generally, dominant resistance genes are used to generate resistance to pathogens. However, these narrow-spectrum genes can be easily overcome by pathogens. Therefore, the best approach to acquire broad-spectrum resistance is to employ altered susceptibility genes (S genes). S genes encode susceptibility factors, facilitate pathogen infection and support compatibility. The molecular mechanisms underlying susceptibility to R. solani are largely unknown. Recently, it has been recognized that necrotrophic pathogens have a short biotrophic phase during infection. In “RiZeSisT” -Rice rhiZoctonia reSisTance- I will identify rice S genes that are essential to establish the early (biotrophic) infection of R. solani. I will exploit mutated (incompatible) S gene(s) to generate resistance to ShBD. After this project we will generate non-GMO mutants for improving elite varieties for broad-spectrum resistance to ShBD. KeyGene acts at the forefront of new technologies and traits to support the development of new and improved crops. Executing “RiZeSisT” at KeyGene, will enable me to use cutting-edge technologies, bioinformatics & data science expertise and plant-based trait platforms to discover the S genes. This is an innovative strategy that has not been used for this pathosystem. Furthermore, there is a high chance to translate my obtained knowledge to generate resistance to R. solani in additional relevant crops as maize, wheat, barley or soybean. The results of “RiZeSisT” will contribute to meet food security needs for our growing population.

Keywords: plant disease resistance,susceptibility gene,plant microbe interaction,pathogen,rice,rhizoctonia solani,sheath blight,necrothroph,transcriptomics,effectoromics,crispr,cas9
Active and Adaptive: Reconfigurable Active Colloids with Internal Feedback and Communication Schemes (ACTIVE_ADAPTIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1997718.0
EU funding (EUR): 1997718.0
Participants: 1
Project status: SIGNED

The vision of creating autonomous materials constituted of microscale motile units promises to disrupt a broad range of technologies but is still far beyond our reach. Inspired by nature, these materials are active, i.e. they convert available energy into functions, and adaptive, i.e. they respond to stimuli by reconfiguring via internal feedback and signalling schemes. In order to progress, we need to rethink the way in which we design, fabricate and control synthetic active units, aka active colloids or artificial microswimmers. I propose an innovative approach that combines colloidal synthesis, assembly and actuation with nanofabrication and the implementation of feedback to realize a new class of active colloids. Borrowing ideas from soft-robotic systems, we aim to realize and study “cyber-free” artificial microswimmers, which, in addition to on-board energy conversion, present internal degrees of freedom allowing for sensing, feedback and communication pathways ultimately to be regulated without external intervention. In particular, we will: 1) Numerically and experimentally implement feedback schemes to regulate single-particle motility and collective behaviour based on control theory. 2) Use a unique combination of capillary assembly and two-photon nanolithography to create shape-shifting active colloids that autonomously regulate their motility based on stimuli orthogonal to their propulsion schemes. 3) Create “transmitting” and “receiving” active colloids, sending and sensing chemical signals (pH changes), to regulate their motility. By introducing strong coupling between particles, and with stimuli beyond classical colloidal interactions, this proposal will enable a forward leap in the study of the emergent physics of active systems, as required to realize the vision of autonomous materials and microscale devices.

Keywords: active matter,active colloids,colloidal assembly,reconfigurable colloids,microgels
Media Motor Europe (MediaMotorEurope)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Ireland,Norway,Greece,Bulgaria,Greece,Belgium,United Kingdom,Portugal
Call: Startup Europe for Growth and Innovation Radar (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2022-04-30
Duration (months): 28.0
Total project cost (EUR): 1952262.5
EU funding (EUR): 1693565.0
Participants: 8
Project status: CLOSED

Nowadays the media sector is moving towards an increasingly digital, mobile, and social media environment with more intense competition for attention; leading to disruptions in the creation, distribution and consumption of media. The media and creative industry in Europe is facing major challenges. Development of deep tech solutions targeting the market have the potential to help EU's media and creative industry to become an even stronger sector. MediaMotorEurope (MME) will boost solutions that can address challenges such as misinformation, accessibility, user interfaces and use of data. Its goal is to nurture high-potential European deep tech innovators, solving today´s most prominent media industry challenges and support them in building the media solutions of tomorrow. To succeed in this challenge, MediaMotorEurope brings together 4 distinct ecosystems in 4 different countries across Europe: Two dedicated media hubs and two strong innovation hubs. Together with European networks of investors and startups, this will ensure that DeepTech StartUps/ScaleUps have access to the resources and prospective clients they need to succeed in accessing the market. In order to support high-potential startups and scaleups in the ecosystem, MME has constructed a dedicated support and mentoring programme. Engagement activities and ambitious selection criteria based on a SWOT analysis will provide the most promising startups with 6 month of intensive support and coaching from MME experts. This MME programme will be repeated 3 times, having the ambition to select and support a total of 60 startups throughout the project. The ambition is that each of the selected innovators will have 3 potential clients in their books by the end of the six-month support period. MME will host and attend a series of events to boost the visibility of the DeepTech solutions provided by the programme participants, creating even more opportunities to bring strong European innovations to the market.

Keywords: media,creative industry,sandbox,media innovation hubs,deep tech
Development of a fully customised, repairable and recyclable polypropylene umbrella that is easy to assemble (PEPLUM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Each year an estimated one billion umbrellas are discarded in landfills globally. Umbrellas typically consist of 120 parts and are made up of various materials such as metals and plastic amongst others. These materials take up to a century to degrade naturally. This volume of waste is an environmental concern as is the squandering of finite resources such as metals. The volume of umbrellas discarded is a result of inefficiencies of umbrellas available in the market. The umbrella stretchers that hold the canopy in place when the umbrella is opened consist of multiple rigid metal pieces joined together with pins and screws. These joints weaken the umbrella structure and as a result the stretchers break easily especially when subjected to strong wind. Furthermore, umbrella repair services are scarce and as a result, whole umbrellas are disposed of even when a single component is damaged. Also, umbrellas are difficult to recycle because they consist of multiple parts of different materials. PLV Srl, established in 2016 to tackle the inefficiencies of umbrellas in the market, has developed an innovative, all-plastic, easy to assemble umbrella whose key innovation is the integrated polypropylene stretcher. Our stretchers consist of one flexible piece designed to alter shape to withstand adverse weather conditions. The multiple joints are eliminated strengthening the structural integrity of our umbrellas. Our umbrellas, consisting solely of plastic are 100% recyclable. In addition, our umbrellas are comprised of just 20 components which are easy to assemble. As a result, when a component is damaged, it can be easily replaced. 900 million umbrellas are sold each year and bringing in revenues of €3 billion each year. PLV Srl aims to sell 3 million umbrellas by 2024 which is 0,6% of the total addressable market. Our umbrellas will cost around €20 and €3 for the separate components. By 2024, we anticipate achieving a net profit of €5.9million and return on investment of 487%.

Keywords: eco umbrella,recyclable,polypropylene
MOde-localized mass Sensors with Thermal Actuation and Piezoresistive DEtection (MOSTAPDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Micro/nano-electromechanical system (M/NEMS) resonant mass sensors have attracted utmost interest over the past two decades. This is due to their wide range of applications, especially in biochemistry, for instance weighing single molecules, nanoparticles, and even monitoring the growth of living cells. However, their performance is significantly decreased when operated at ambient air and measurements take a considerable time. Therefore, there are two main challenges for MEMS resonant mass sensors: (i) the improvement of the quality factor at ambient atmospheric pressure; (ii) the realization of real-time monitoring with a closed-loop control and interface circuit system. Additionally, higher sensitivity is always a desirable property to further increase the performance of mass sensors. In this project, entitled “MOde-localized mass Sensors with Thermal Actuation and Piezoresistive DEtection (MOSTAPDE)”, I aim addressing aforementioned challenges by combing thermal actuation and piezoresistive detection for MEMS resonators. With this approach a quality factor of several thousand at ambient pressure can be achieved. As a further novel approach, it is proposed to weakly couple two resonators and exploit the phenomenon of mode localization; by using the amplitude ratio as readout metric compared to the commonly used frequency modulation method; in this way the sensitivity can be enhanced by 2-3 orders of magnitude. Furthermore, the inherent common mode rejection property of mode-localized sensors can be exploited for higher robustness. Finally, particle contamination and blockage are avoided as the proposed sensors do not require small electrode-gaps as conventional capacitive sensors. For the microfabricated sensors, a closed-loop control circuit will be constructed to enable real time monitoring. We plan to demonstrate the concepts for measuring particulate matter, which is a major air pollutant, as a practical application of mass sensing.

Keywords: mass sensor,mode localization,thermal actuation,piezoresistive detection,quality factor,sensitivity,closed loop circuit