Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS (INKplant)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Austria,Germany,Spain,Israel,Germany,Austria,Austria,France,Netherlands,Portugal
Call: Biological scaffolds for tissue regeneration and repair (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 5988155.0
EU funding (EUR): 5988155.0
Participants: 19
Project status: SIGNED

Improving the life quality of Europe’s increasingly elderly population is one of the most pressing challenges our society faces today. The need to treat age-related degenerative changes in e.g. articular joints or dental implants will boost the market opportunities for tissue regeneration products like biological scaffolds. State of the art 3D printing technologies can provide biocompatible implants with the right macroscopic shape to fit a patient-specific tissue defect. However, for a real functionality, there is a need for new biomaterials, technologies and processes that additionally allow the fabrication of a scaffold microstructure that induces tissue-specific regeneration. It is not possible to address the complexity in structure and properties of human tissues with a single material or fabrication technique. Besides, there are many types of tissue in the human body, each with their own internal structures and functions. INKplant vision is the fusion/combination of different biomaterials (6 different inks), high-resolution, high throughput additive manufacturing technologies already proved for industrial processes (ceramic sterolithography and 3D multimaterial inkjet printing), and advanced simulation and biological evaluation, to bring a new concept for the design and fabrication of biomimetic scaffolds (3D printed patient specific resorbable cell-free implants) which can address the complexity of the different tissue in the human body, demonstrated for 2 Use Cases. For a successful future translation, INKplant will consider all the relevant clinical adoption criteria already at the beginning of the development process. To address INKplant challenging objective the consortium includes the best expertise from the main areas of relevance to the project: biomaterials, 3D printing technology, tissue engineering, regulatory bodies and social humanities.

Keywords: biomaterials,biomimetic scaffolds,3d multi material inkjet printing,ceramic additive manufacturing,high throughput,industrial process,hybid manufacturing,ostheochondral,dental,ethics,biological eval
Giving Drivers Access to Conventional and Electric Car Parking Lots Through the WeSmartPark Enhanced Management System (WeSmartPark)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

WeSmartPark represents a novel technology suite that allows utilizing existing underused parking lots in densely populated cities that will feature electronic charging stations. At no cost to the parking lot owner, equipment is installed that tracks availability and occupancy in real time. The drivers can view, reserve and find parking spots via web browser or mobile app. WSP is the first of its kind in terms of parking management and using under-used private parking lots. Drivers spend around 20-30% of their driving time in densely populated cities on finding parking lots. At the same time, existing parking lots are only used 60% of the time. On average, WSP offers parking that is at least 50% lower than the average cost in any given city. In Barcelona, WSP charges 1.44 euros per hour, which is less than half of the average price. The overall objective for the Phase II project is to have launched our validated business model of Barcelona and Madrid to other Spanish and European cities. Some with electric car charging capabilities depending on the outcome of Phase I. This will require specific upgrades of our existing product and the integration of electric car charging capabilities. Our specific objectives for Phase I are a technological feasibility study of electric car charging lots, an assessment of technological redesign needs, market assessment, business model assessment, risk assessment, IP assessment, work plan for Phase 2 and a Business Plan. Our product will help meet a series of European transport (better urban mobility, less vehicle congestion) and environmental challenges (reduction of CO2 emissions). In addition, we will help achieve the European Commission’s goal to create a tight network of electric car charging stations. The project will enhance our profitability significantly.

Keywords: parking technology,rfid technology,enhanced parking,resource efficiency,mobility,electric car,charging,antenna,sensor technology,parking access system,parking management
understandinG the Role of codon usAge biaS in viruS HOst jumP ProcessEs thRough statistical physics (GRASSHOPPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Assessing the pandemic risk for viruses of zoonotic origin is extremely hard, but its importance motivates a steadily growing interest. The approaches used so far are hindered by the limited knowledge of the complex interactions of viral genomes with human cells. Within the framework of the global research effort to fill this gap, this action aims at unveiling the relevance of specific genomic features, especially those related to the codon usage bias, in the process of viral host jump. Two objectives are established: (i) identify and quantify the host-induced pressures on viral genomes; (ii) use these pressures to quantify the likelihood of host jumps. To address objective (i), the host-induced pressures will be inferred from large public databases of viral genomes, in the spirit of inverse problems in Statistical Physics. The results will be validated through experiments performed in collaboration with an experimental group at Istitut Pasteur (Paris). The results of objective (i) will be used in objective (ii) to take into account the compatibility of the viral genome with the host-induced pressures in a simple model of host jump. The Applicant will benefit from a secondment at University of Basel where he will acquire useful skills for this challenging objective. The ambitious aims of this action will be achieved via a strongly interdisciplinary approach, which will build on the existing skills of the Applicant, who specialized in combinatorial optimization problems and Statistical Physics of disordered systems during his PhD, together with the expertise of the Supervisor on inference and Statistical Physics models applied to biology topics. The proposed project is expected to have practical impact on vaccine strain design and virus surveillance strategies. Moreover, it will allow the Applicant to benefit of a unique training scheme, in contact with several top-level institutions in EU, and in close collaboration with internationally recognized researchers.
From surrogate hemodynamics-based fMRI towards direct functional imaging of neural activity via sensing activity-induced cell swellings and neurotransmitter releases in vivo (SPECIFIC fMRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag ‘active’ brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known. We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-MRI is an exquisite microstructural probe, sensing cell sizes (l) with an unprecedented l^6 sensitivity (compared to l^2 in conventional approaches); RE MRS is a new spectral technique capable of recording metabolic signals with extraordinary fidelity at ultrahigh fields. This proposal aims to harness these novel concepts for mapping neural activity directly, without relying on hemodynamics. The specific objectives of this proposal are: (1) Mapping neural activity via sensing cell swellings upon activity: we hypothesize that NOGSE-fMRI can robustly sense subtle changes in cellular microstructure upon neural firings and hence convey neural activity directly. (2) Probing the nature of elicited activity via detection of neurotransmitter release: we posit that RE MRS is sufficiently sensitive to robustly detect changes in Glutamate and GABA signals upon activation. (3) Investigating widespread neural circuits in vivo via stroboscopic optogenetics: we propose to couple NOGSE-fMRI with optogenetics to resolve casual dynamics in global neural circuitry. Simulations for NOGSE-fMRI predict >4% signal changes upon subtle cell swellings; further, our in vivo RE MRS experiments have detected metabolites with SNR>50 in only 6 seconds. Hence, these two complementary –and importantly, hemodynamics-independent– approaches will represent a true paradigm shift: from indirect detection of neurovasculature couplings towards direct and noninvasive mapping of neural activity in vivo.

Keywords: magnetic resonance imaging,functional imaging,fmri,neurotransmitters,in vivo,neuronal swelling,diffusion,functional connectivity
Shadowing, Omega Limit Sets and Internal Chain Transitivity in Dynamical Systems (ShadOmIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-30
End date: 2017-08-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project aims to bring Dr Jonathan Meddaugh, one of the most promising young dynamicists of his generation, to the University of Birmingham to work with Dr Chris Good on a project that aims to capitalize on recent exciting developments in the theory of dynamical systems. Key to the analysis of dynamical systems are the asymptotic behaviour captured by limit sets and an understanding how computed (approximate) orbits correspond to true orbits, i.e. how pseudo-orbits are shadowed by real orbits. In recent work, Meddaugh has shown that shadowing is closely linked to characterizations of limit sets in terms of internally chain transitivity developed by Good and his collaborators. This project will develop the general theory behind these links and, using innovative applications of non-Hausdorff topologies and symbolic dynamics, make significant contributions to our understanding of shadowing and limit sets in a number of important families of dynamical system, such as shift spaces and polynomial maps on their Julia sets. During the project Meddaugh will develop the professional skills that will place him in an ideal position to secure a leading academic position.

Keywords: dynamical systems,shadowing,limit sets,chain transitivity
Homotopy Theory of Moduli Spaces (HToMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 974526.0
EU funding (EUR): 974526.0
Participants: 1
Project status: SIGNED

Moduli spaces are spaces which describe all mathematical objects of some type. This proposal concerns the study of certain moduli spaces via techniques from homotopy theory, from several different points of view. The main moduli spaces in which we are interested are moduli spaces of manifolds, or equivalently classifying spaces of diffeomorphism groups of manifolds. We are also interested in spaces of positive scalar curvature metrics on smooth manifolds, which we study by relating them to moduli spaces of smooth manifolds. The study of moduli spaces of manifolds via homotopy theory has seen a great deal of development in the last 20 years, the breakthrough result being Madsen and Weiss' calculation of the stable homology of moduli spaces of surfaces. More recently, Galatius and I have established analogous results for manifolds of higher dimension. A main goal of this proposal is to study the homology of moduli spaces from a multiplicative point of view. This leads to higher-order forms of the phenomenon of homological stability in which the failure of ordinary homological stability is itself stable. Remarkably, our methods developed to handle moduli spaces of manifolds are sufficiently general to yield deep new results when applied to other moduli spaces in algebra and topology, such as moduli spaces of modules (equivalently, classifying spaces of general linear groups) or moduli spaces of graphs (equivalently, classifying spaces of automorphism groups of free groups). In each case our methods give new information about their homology outside of the traditional stable range. Other goals of this proposal are to form new connections between spaces of Riemannian metrics of positive scalar curvature and infinite loop spaces, and to investigate the structure of tautological subrings of the cohomology of moduli spaces of manifolds, especially in relation to the tautological rings of moduli spaces of Riemann surfaces studied in algebraic geometry.

Keywords: homotopy theory,moduli space,mapping class group,general linear group,automorphism group of free group,e n algebra,homological stability,algebraic k theory,positive scalar curvature,cobrdism
Centre of Excellence (CoE) Lisbon International Centre for Water (LIS-Water)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: France,United Kingdom,Portugal
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399620.0
EU funding (EUR): 399620.0
Participants: 3
Project status: CLOSED

LIS-Water is an initiative of the National Laboratory of Civil Engineering (LNEC) to create in Portugal an international CoE for frontier R&I on water services and related water resources with a high impact on public policies, management and regulation in Portugal, Europe and worldwide. LIS-Water results from a long-term teaming process between LNEC, a recognized centre of R&I from a low-performing EU R&I Member State (Portugal), and 2 top institutions of R&I excellence from advanced Member States (UK and France) - Cranfield Water Science Institute (Cranfield University) and Sorbonne Graduate Business School (Université Paris1 Pantheon-Sorbonne). LIS-Water´s vision is to develop excellent scientific and technological R&I for improved water services and related water resources management, essential to the well-being of citizens and economic activities, with a strong improvement effect on public health and environment. It will contribute to a more developed and healthier society. It will build an innovative, open and widely recognized international CoE on water services as well as related water resources. The Portuguese Ministry of Environment has identified that LIS-Water is essential for the development of the Portuguese water sector and its competitiveness in the international market and is committed to ensure the long-term nature and accountability of LIS-Water, including funding of an estimated minimum amount of 15 million euros in 7 years. LIS-Water will have a strong impact along the water value chain, from an increased and more qualified scientific critical mass to an improved business environment for water-related companies, including a sustainability-friendlier policy context and improved education, training and capacity building. It will help tackle current and new societal challenges, contributing to a more developed society, engaging all key stakeholders (universities, research organisations, policy makers, regulators, water utilities, industry, CSOs).

Keywords: water services,water resources,water management,centre of excellence,business plan
Commercial feasibility of non-pathogenic Clostridium-Mediated Cancer Immunotherapy: leveraging the presence of tumour hypoxia & necrosis (CL-IO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-03-31
Duration (months): 18.0
Total project cost (EUR): 150802.5
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Immunotherapeutic strategies are powerful weapons in combating malignancies. However, only a minority of patients benefit from this therapeutic modality, as tumours develop mechanisms of immune escape and suppression and uptake of (antibody-based) agents in tumors is limited. The urgency of investigating novel strategic approaches is dictated by the high incidence and mortality rates of cancer worldwide. Lung cancer, in particular, is the leading cancer with respect to incidence and mortality (14% of new cancers). In the ERC Advanced “HYPOXIMMUNO”, Prof. Lambin and his team have investigated the trimodal therapy involving high precision Stereotactic Radiotherapy, hypoxia/necrosis targeting and tumour specific immunotherapy (immunocytokine L19-IL2 to “push the accelerator” with a checkpoint inhibitor to “release the break”). Despite promising results, the delivery of immunotherapeutics to the tumour site has proven to be challenging. Prof. Lambin and his team have sought to overcome this limitation with the inclusion of genetically-modified Clostridium bacteria as optimal delivery system capable of effectively delivering immunotherapeutics within the tumour. These Clostridium-bacteria selectively colonise the hypoxic/necrotic regions present in solid tumours and act as cellular factories capable of continuously producing tumour-specific immunotherapies within the tumour (watch https://vimeo.com/251022032 ). In this ERC PoC project, a team of technological and commercial experts will investigate the commercial feasibility of this innovative approach. We will prepare the first steps towards the start-up of a spin-off, by defining the exact business strategy, model and positioning for commercial success. We will develop the business strategy based on the technological aspects, the market needs and trends, and the IP-position. During CL-IO, we will gain technical and commercial proof-of-concept, providing the necessary information for potential commercialisation routes.

Keywords: hypoxia,necrosis,cancer immunotherapy,immunocytokines,lung cancer,clostridium mediated cancer immunotherapy
Topological order beyond the equilibrium ground state: driven quantum matter and magnon excitation spectra (ExcitingTopology)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-12-01
End date: 2022-03-01
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

With the discovery of topological order, condensed matter physics has witnessed a revolution in how phases of matter ought to be defined and characterized. Unlike spins aligning in a magnet, topological phases are not classified by symmetry breaking but instead require nonlocal invariants that relate to the mathematical domain of topology. This theme took a turn with the finding that even common electronic band structures can feature topological invariants in the presence of appropriate symmetries. Ever since, many such symmetry protected topological (SPT) states have been predicted and arranged into a unifying table. These developments have been accompanied by the actual realization of various topological band insulators that feature striking properties including protected metallic edge states and proposed exotic fractionalized excitations, which may provide a route to fault-tolerant topological quantum computing. Now, the field is approaching a new exciting turning point as indications are emerging that other parts of the modern 'Mendeleev table' exist involving band structures that do not pertain to equilibrium ground states. On the verge of this milestone, this project will take a pioneering role and investigate such SPT phases in the context of periodically driven quantum systems and magnon excitation spectra. The objective is to uncover the underlying general classification principles, which will provide a guide to engineering novel states and accordingly new physics. To this end, we will apply a multidisciplinary approach combining state-of-the-art handles on SPT order, insights from analytically tractable models and numerics. In particular, we envision that naturally present crystal symmetries will play a prominent role here -one that has yet to be appreciated- much as they do in equilibrium SPTs. Together with a complementary generalization of physical observables, we expect this action to pave the way to a new chapter in the success story of SPT phases.

Keywords: topological insulators,topological band theory,floquet systems,topological classification,magnons,crystalline symmetries,symmetry protected topological matter,driven quantum systems