Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Systems Neuroscience of Metabolism (SYNEME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2212500.0
EU funding (EUR): 2212500.0
Participants: 1
Project status: CLOSED

Proopiomelanocortin (POMC)- and Agouti-Related Peptide (AgRP)-expressing, i.e. melanocortin neurons in the hypothalamus, are key regulators of feeding behaviour, glucose metabolism, autonomic responses and higher cognitive functions. They represent targets for fuel-sensing hormones like leptin and insulin that thereby control key processes in systemic energy and glucose homeostasis. Importantly, resistance to these fuel-sensing signals is known to contribute to the current obesity and diabetes epidemic. Consequently, altered POMC- and AgRP-neuron regulation in obesity contributes to the development of numerous metabolic alterations. Although the melanocortin neurons as central regulators of metabolism have been classified according to the expression of their characteristic neuropeptides, it has only recently become clear that even within these populations they represent distinct heterogeneous neurons with respect to their physiological regulation and the biological responses governed by their specific downstream neurocircuits. However, the molecular nature of heterogeneous POMC and AgRP neuron populations, their specific neurocircuitry architecture and their specific functions still remain largely unexplored. Therefore, we will employ a wide array of state-of-the-art molecular systems neuroscience and modern mouse genetics approaches to define (1) the anatomical distribution, (2) molecular signature, (3) neurocircuitry architecture, (4) regulatory principles, (5) specific biological functions, and finally (6) novel druggable regulators of these specific POMC and AgRP microcircuits. We anticipate that the new knowledge generated will not only provide novel insights into the fundamental principles of CNS-dependent control of metabolism but could also lead to targeting these specific neurocircuits to develop novel, specific, tailor-made therapies for diverse aspects of metabolic diseases for which currently only insufficient treatment options are available.

Keywords: obesity,type 2 diabetes mellitus
On the route of multiculturalism(s). Marking and hybridizing identities in the late 17th and early 18th centuries Mediterranean port cities (MedRoute)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

This project aims to analyze the phenomenon of multiculturalism in four Mediterranean port cities of the late seventeenth and the early eighteenth centuries. The research uses three identity markers (foodways, clothing, and language) to chart how differences in the political and physical environments affect the balance between marking and hybridizing identities in the port cities of Izmir, La Valletta, Livorno and Marseille. Although very different amongst themselves, these four cities, placed on a maritime trading route cutting the Mediterranean from east to west, share a highly developed cultural, ethnical, and religious pluralism. The comparative analysis adopted will shed light on the concept of multiculturalism(s) in the pre-modern Euro-Mediterranean space, explaining how members of the same group handled coexistence following different strategies. In analyzing identity as a dynamic process, the research enters into the historiographical debate on the One-Plural nature of the Mediterranean on two critical levels: the ways in which Mediterranean identities interact with one another and how they generate a multicultural zone. Through an interdisciplinary study, the project will shape the ineradicable ambiguous nature of multicultural zones in the Mediterranean. This goal will be undertaken through the analysis and verification of three main assumptions that form the basis of the research: 1. The role of the political factor in determining the type of multiculturalism which developed and the ethical role of politics in assuming tolerance as a tool for fostering a more vibrant and resourceful society. 2. The role played by internal members of the communities on the basis of social class, education and gender, and how these factors determined the individual positioning on the scale from integration to segregation. 3. The functionality of multicultural policies in enhancing urban welfare.

Keywords: mediterranean,port city,migration,identity markers,cultural hybridization
Navigating the evolutionary routes of influenza viruses (NaviFlu)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1999331.0
EU funding (EUR): 1999331.0
Participants: 1
Project status: SIGNED

Seasonal influenza viruses re-infect us repeatedly, escaping antibody recognition, due to the evolution of the virus itself. Being able to predict when and how the virus will evolve would be transformative for influenza virus control. Problematically, we have only observed one of the likely many possible routes of virus evolution. We do not know how many viable routes may have existed or about the repeatability of the observed evolution. These knowledge gaps limit the predictability of influenza virus evolution. NaviFlu will fill these gaps by rigorously assessing the repeatability of influenza virus evolution and the diversity of routes the virus can explore. Recent work has shown that prolonged influenza virus infections can result in substantial virus evolution and occasionally portend virus mutational patterns on a global scale. However, observing large numbers of such infections is challenging. We will use an innovative ex-vivo human airway epithelium culture system to artificially create and study prolonged human infections. Together with cutting-edge next generation sequencing and new analysis tools, we will quantify the evolutionary landscape of seasonal influenza viruses. The project has three objectives, each building in complexity: 1–Quantify the evolutionary dynamics of seasonal influenza viruses in the absence of antibody-mediated selection. 2–Determine how the antibody complexity of immune sera shape the evolutionary trajectories of virus antigenic evolution. 3–Quantify the impact of differences in selection pressures by site of infection and underlying host variation on virus evolution. Through these objectives we will “play evolution forwards”, revealing the relative roles of different factors governing the mode and tempo of influenza virus evolution and quantify the predictability of virus evolution. This will improve the design of influenza vaccines, enhance prospects for influenza control, and lay new groundwork for exploring virus evolution.

Keywords: influenza viruses,evolutionary fitness landscapes,long term evolution,experimental evolution
Inflection Bioscience unique dual mechanism, small molecule, orally available therapeutic targeting major unmet medical needs in breast cancer (IBL-302)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Breast cancer is already a leading cause of death among women and most common form of cancer among European women with almost 500,000 cases in 2012 and over 1.7 million new cases globally. However, despite good progress in treatment options over the past decade, including some progress with immunotherapies, the war is far from won, with over 20% not responding to current standard care, and with the incidence of breast cancer set to rise by a massive 50% by 2030. There is now an urgent need for new effective, safe and life extending therapeutics for those women suffering and dying with breast cancer. IBL-302 is a first-in-class small molecule targeted breast cancer therapeutic that targets both the PI3K and PIM pathways. It is an orally bioavailable pan-PIM kinase, pan-PI3K and mTOR inhibition in a single agent. As the PI3K pathway is one of the most commonly mutated pathways, this multi-path action effect closes down the main route of mutation and a primary backup PIM pathway. This confers the promise of much greater rates of efficacy and potential utility to combat the breast cancer epidemic. Inhibition of the PI3K pathway alone is cytostatic, it pauses cell growth but does not kill cancer cells. This has the effect of the PIM pathways then being activated as a backup mutation pathway, allowing the cancer to progress once more. Adding PIM inhibition on top of the PI3K inhibition actually induces apoptosis, the death of cancer cells instead of simply stalling their growth. A development partnership will be sought with a large pharmaceutical company to complete final stages of clinical development required for market approval. The partner will also be responsible for the manufacture and distribution IBL-302 on an exclusive licence.

Keywords: breast cancer,improved outcomes,clinical trials,pathway inhibition,pi3k
ALOe vera Edible Coating: effective, safe and sustainable post-harvest treatment to enhance shelf-life of vegetables (ALOEco)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The demand of fresh fruits and vegetables is increasing gradually. However, fresh fruit and vegetables are perishable products whose freshness is difficult to maintain along the supply chain. There is a need for reduction of post-harvest food loss by increasing the efficiency of the whole food chain, as one of the first means to fight imbalances and reduce tensions between the increase in food consumption and the challenging increase in food production. At the same time, primary producers are facing the challenge of reducing the use of chemicals to comply with ever stricter regulations. Therefore, there is a market need for 100% organic solutions to increase the shelf life of fresh products and reduce food waste. Among the existing solutions, edible coatings are the most promising to prevent vegetable food-loss and extend vegetable shelf life. However, there are very few solutions free of synthetic additives and suitable for the organic market. To contribute to solve this challenge, we aim to bring to the market our in-house developed product: ALOEco – a 100% organic, effective, safe and sustainable Aloe vera-based post-harvest edible coating. ALOEco extends a 40% the shelf life of vegetables, reducing by 100% the need for post-harvest fungicides, also reducing the energetic requirements for post-harvest conservation, the residue levels on fresh vegetables and the need for synthetic packaging. Our initial sales forecast shows potential cumulative revenues of 12.1 M€ thanks to sales of 4,000 m3 of ALOEco in Europe.

Keywords: edible coating,organic,shelf life
Web Accessibility Directive Decision Support Environment (WADcher)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Austria,Ireland,Germany,Cyprus,Greece,Greece
Call: Interfaces for accessibility (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 2129005.0
EU funding (EUR): 1957011.25
Participants: 8
Project status: CLOSED

One of the many challenges people with various degrees of disabilities face is their difficulties in accessing mainstream products and services thus being excluded from benefiting from Web content and services on an equal basis as people without disabilities. Marginalising people with disabilities on this level is a critical and problematic issue, especially in today’s “Information Society”, where access to information should be equally available to all. While these challenges have been identified (also by EC with the recently Web Accessibility Directive which was entered into force on 22/12/2016), they have not been addressed yet efficiently. In this context and building on ongoing tools and work, WADcher will research, develop and demonstrate an innovative Decision Support Environment for large scale hybrid web accessibility assessment services. WADcher aims to build a large scale infrastructure by integrating extended and enhanced existing web accessibility solutions, and by also making them customizable to the needs of different stakeholders in EU member states. The minimisation of costs and development time along with increased scalability, accessibility and usability for all types of end-users will be also analysed. Specifically, the WADcher Innovation Action will be based on the following pillars: 1) build a large scale accessibility assessment infrastructure; 2) develop and demonstrate advanced decision support tools for assisting developers and designers to create accessible assets; 3) implement a web accessibility observatory platform for hybrid combination of automatic/expert reviews; 4) validate WADcher results under a significant number of pilots and users and a coherent Web Accessibility Conformance methodology; 5) develop methods and tools with which organizations can measure the evidence, accuracy and quality of testing results; 6) liaise with relevant standardisation bodies and create needed impact through proactive dissemination and exploitation.

Keywords: web accessibility,web standards and recommendations,markup,aria,html5,css3,mobile web,observatory,public sector,business intelligence,data analytics,machine learning
Market launch of an autonomous and online based hydrogen sulfide (H2S) Analyzer for the implementation of IIoT - digitalization of the sewer system (H2S Analyzer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 2497500.0
EU funding (EUR): 1748250.0
Participants: 1
Project status: CLOSED

There is a huge environmental problem in our sewers: hydrogen sulphide (H2S). H2S causes massive ecological problems and economic damage, which arise to more than €250 bn per year in Europe. Currently, high levels of chemicals such as Nutriox are used in the sewer to eliminate H2S. However, the use of chemicals could be drastically reduced if measures are taken at the point of origin, the waste water collection point. This requires an autonomous measuring method that can detect even the smallest H2S concentrations on site and online. We as ECH have developed such an Analyzer. The H2S Analyzer (TRL 7) is based on a new, patented measurement method - gas extraction with coupled detection. A higher-level control system connects several H2S Analyzer with each other and always determines the required quantities of waste water chemicals precisely on the basis of the measurement results. We make the waste water industry digital with this technology and enable a complete real-time monitoring of the whole system. Target customers are municipal and private companies in the wastewater industry, but also contract laboratories (market volume Europe: €1.5 bn). Our advantages are: 1.Automate online measurements - H2S can be measured autonomously at various points in the wastewater pipe without personnel. - real-time Monitoring and targeted influencing 2.Exact and reproducible measuring method -Measurement of H2S occurrences from 0.01 ppm 3.Environmentally friendly - Proven significant reduction of at least 40-50% in the use of chemicals to treat H2S - Increased service life wastewater system to 100 years (currently 10-60) 4.Economic viability - Decreasing costs for replacement investments in wastewater infrastructure - Cost savings of >40% The H2S analyzer is seen as a key factor in ECH and leads to significant increase of sales and employees and, in the long term, a reduction in the use of chemicals in the wastewater industry. H2S Analyzer - Good for you and the Environment.

Keywords: water analytical device,h2s analyzer,hydrogen sulphide,groundwater protection,sulphuric acid,corrosion,waste water industry,waste water infrastructure,iiot,digitalization waste water
MiRNAs as therapeutics for neurorepair in Multiple Sclerosis (MiRepair)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: SIGNED

I hope to embark my first post-doctoral position, as a MSCA fellow, to identify microRNAs (miRNAs) involved in demyelination/remyelination processes with the final intention of modulating their expression as a therapeutic tool to promote neurorepair in multiple sclerosis (MS). MS is a chronic neurological disease of the central nervous system characterised by primary demyelination. All current disease-modifying therapies are unable to induce neurorepair and to prevent the progressive accumulation of disability from neuronal damage. miRNAs are one epigenetic mechanism involved in the genes-environment interaction that produces the pathology and symptoms in MS. My thesis project consists of describing miRNAs profiles in cerebrospinal fluid and serum of MS patients to exploit their potential role as clinical biomarkers. This project will combine these human miRNA data with robust experimental models in order to identify miRNAs involved in the damage and endogenous repair associated with MS. I will employ ex vivo models to study the biological role of miRNAs during these processes and how their manipulation might enhance neurorepair. The use of hydrogel-scaffolds in combination with miRNA modulators to enhance remyelination will be studied and preclinical MS in vivo models will be used to assess their therapeutic potential. I will work at the “microRNA Inflammation Group” in the Royal College of Surgeons in Ireland (RCSI) under mentorship of Dr Claire McCoy, a leader of MS research in Ireland. Two secondments have been planned in the National University of Ireland, Galway (NUIG) and Queen’s University Belfast (QUB). This fellowship will enable me to upskill in research techniques and expand my transferable skills and competences for a career path for academia or industry in miRNA therapeutics area. This will enhance and contribute to Europe’s competitiveness in R&I supporting European policy objectives as promoting excellence in education and skills development.

Keywords: multiple sclerosis,mirnas,neurorepair
Developing a new Network of Researchers on Contemporary European Motherhood (MotherNet)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Ireland,Sweden,Lithuania
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 898178.75
EU funding (EUR): 898178.75
Participants: 3
Project status: SIGNED

The overall aim of the MotherNet project is to enhance the scientific excellence and research capacity of Vilnius University (Lithuania) and raise the profile of its research staff and their institution by linking an emerging body of researchers working on motherhood to world-class centres for research on motherhood at Uppsala University (Sweden) and the National University of Ireland Maynooth (Ireland). The work plan envisions: joint design and implementation of collaborative research projects; the creation of targeted training and mentoring programmes; the organization of three international summer schools; extensive inter-institutional mobility; cooperative training of postgraduate students and early-career researchers; coordinated promotion of research outputs; collaboration on a number of major grant applications; and an ambitious programme of dissemination and communication measures. The expected impact of this 3-year programme is the creation of an innovative, interdisciplinary research network that will endure beyond the lifetime of the grant and will make a significant contribution to improving the quality of maternal care and support services in the three countries involved; influence policies relating to work/life balance; and increase public awareness about the changes in the social construction of motherhood in contemporary European society. Most importantly, through these activities, the MotherNet project will significantly enhance the networking channels of VU researchers and increase the visibility and international impact of their research.

Keywords: motherhood,mothering,mothers,gender studies,women s studies,cultural studies,community based research,engaged research,narrative research,literary studies,media studies