Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterization of Multiscale Interfaces of Hierarchical High-Entropy Alloys by Advanced Microscopy and Microanalysis (MultiScaleDesign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 184820.16
EU funding (EUR): 184820.16
Participants: 2
Project status: SIGNED

The aim of the fellowship is to establish methodology for characterisation of a new class of technologically important hierarchical materials with functional multiscale interfaces designed to control their mechanical and thermal stability. The research will rely on a comprehensive study of novel biomimetic multielement high-entropy alloys produced with unique microstructures by bottom-up approaches, allowing for (i) understanding the process-structure-property relations of advanced hierarchical alloys for challenging safety-critical applications, (ii) identifying the role of multiscale interfaces in structurally complex materials on their mechanical and thermal stability, which will subsequently allow for (iii) designing new perspective materials possibly solving the strength-toughness trade-off dilemma limiting the replacement of traditional materials by more perspective materials. The fellowship is also aiming to fill the gap in the knowledge in the beneficiary on in-depth structural characterization of hierarchical materials with multiscale interfaces by advanced characterisation techniques. This will be achieved by (i) in-depth hands-on training on electron microscopy and atom probe tomography in the host institution focused on characterization of structural features spanning multiple length-scales, (ii) transfer of the knowledge to the beneficiary, (iii) establishing an internationally recognized research group in the beneficiary with a focus on the synthesis, in-depth structural and mechanical characterization of novel hierarchical biomimetic mechanically and thermally stable materials for safety-critical applications and (iv) strengthening the collaboration with the host institution. The scientific work is expected to have a strong impact on a variety of multidiscipline applications, in which microstructural design plays an important role in controlling the material properties, especially during research following the incoming phase of the fellowship.

Keywords: multi scale interfaces,characterization methods,electron microscopy,atom probe tomography,materials design
Clinical performance validation of a novel biomarker for quantitative imaging of coronary artery disease. (MPIPETrace)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Poland
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2015, 2015)
Start date: 2015-10-01
End date: 2019-03-31
Duration (months): 42.0
Total project cost (EUR): 3687250.0
EU funding (EUR): 3687250.0
Participants: 1
Project status: CLOSED

Coronary Artery Disease (CAD) is the most common form of heart disease and is the leading cause of death in Europe and the Western World. Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI) offers the unique possibility of measuring and quantifying myocardial blood flow and coronary flow reserve in absolute terms, which serve as a prognostic marker for adverse cardiac events: It can predict the risk of heart attack. PET also offers advantages such as: superior image quality and diagnostic ability, reduction of unnecessary invasive downstream procedures and reduction of patients’ risks due to reduced radiation doses and shorter period of radiation retention. Currently, there is a shortage of available, simple and efficient PET myocardial perfusion imaging agents. Motivated by the growing business opportunity in PET cardiac imaging and the success of completed synthesis and evaluation discovery process, as well as pre-clinical trials and toxicity tests, the objective of this project is Phase 1 and 2 clinical trials of the novel biomarker [11C]-DMDPA for Myocardial Perfusion Imaging using Positron Emission Tomography, and to commercialize it globally. The adoption of Positron Emission Tomography for Myocardial Perfusion Imaging will occur as a result of numerous advantages and the growing abundance and availability of PET scanners in recent and future years. There is compelling evidence that our novel biomarker is addressing a high growth trend in a high volume market of the cardiovascular disease nuclear imaging, and specifically the growing need of non-invasive PET cardiac probes. According to publications, the projected growth rates indicate that PET will outnumber SPECT cardiac procedures by 2020. The willingness to pay has been confirmed during our economic feasibility assessment of the project, by means of consultancy with key stakeholders and negotiations with a number of key players on Diagnostic Partnering deals.

Keywords: myocardial perfusion imaging,nuclear medicine,radiopharmaceuticals,pharma,nuclear imaging,spect,coronary artery disease,probe,clinical trials
Fundamental physics, Cosmology and Astrophysics: Galaxy Clusters at the Cross-roads (ClustersXCosmo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy,Italy
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1230403.0
EU funding (EUR): 676229.92
Participants: 2
Project status: SIGNED

The ClustersXCosmo ERC Starting Grant proposal has the goal of investigating the role of Galaxy Clusters as a cosmological probe and of exploiting the strong synergies between observational cosmology, galaxy formation and fundamental physics related to the tracers of the extreme peaks in the matter density field. In the last decade, astronomical data-sets have started to be widely and quantitatively used by the scientific community to address important physical questions such as: the nature of the dark matter and dark energy components and their evolution; the physical properties of the baryonic matter; the variation of fundamental constants over cosmic time; the sum of neutrino masses; the interplay between the galaxy population and the intergalactic medium; the nature of gravity over megaparsec scales and over cosmic times; the temperature evolution of the Universe. Most of these results are based on well-established geometrical cosmological probes (e.g., galaxies, supernovae, cosmic microwave background). Galaxy clusters provide a complementary and necessary approach, as their distribution as a function of time and observables is sensitive to both the geometrical and the dynamical evolution of the Universe, driven by the growth of structures. Among different cluster surveys, Sunyaev Zel'Dovich effect (SZE) detected catalogs have registered the most dramatic improvement over the last ~5 years, yielding samples extending up to the earliest times these systems appeared. This proposal aims at using a combination of the best available SZE cluster surveys and to interpret them by means of state-of-the-art computational facilities in order to firmly establish the yet controversial role of Galaxy Clusters as a probe for cosmology, fundamental physics and astrophysics. The timely convergence of current and next generation multi-wavelength surveys (DES/SPT/Planck/eRosita/Euclid) will be important to establish the role of Galaxy Clusters as a cosmological tool.
INtegrated Support of oPen Innovation pRofessionalization initiative (INSPIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Finland,Lithuania,Belgium,Greece,Sweden,United Kingdom,Luxembourg,United Kingdom
Call: Professionalization of open innovation management in SMEs (H2020-INNOSUP-2015-3, 2015)
Start date: 2016-04-01
End date: 2019-07-31
Duration (months): 40.0
Total project cost (EUR): 1692742.5
EU funding (EUR): 1692742.0
Participants: 10
Project status: CLOSED

Current research and practice on Open Innovation (OI) has not given emphasis on the ability of SMEs to develop and implement OI strategies - the lessons learned from large firms are not readily transferable to their context. INSPIRE aims to thoroughly investigate how OI is managed and organised in SMEs in order to leverage and expand the existing scattered initiatives and professionalize their services. The project seeks to understand in depth good practices of OI in SMEs across Europe, including the barriers they experience, the critical success factors and the open innovation ‘pathways’ they follow. Good practices will be identified in all varieties of SMEs in terms of economic context, innovation trajectory (e.g. both high-tech and low-tech SMEs) and stage of lifetime. The understanding of good practices will allow the design, development and validation of an Integrated Toolbox for OI in SMEs to enable the professional management of OI by SMEs in various kinds of open innovation initiatives (e.g. facilitated by large corporations, private-public partnerships). The Toolbox will include good practices, indicators and management modules to support the internal innovation activities of an SME and their interaction with OI partners. The Toolbox will be modular and it will include three prototypical scenarios of usage that can be flexibly adjusted to individual needs of SMEs. The Integrated Toolbox will be developed as a web platform and it will be validated through a series of pilots in real life OI projects carried out by SMEs across Europe. Moreover, the project will develop a deployment plan for the Open Innovation System to initiate an EU-wide strategic engagement of innovation stakeholders and spread the practices of OI. The consortium includes a variety of competencies to access the whole Open Innovation chain across a range of geographical, economic and SMEs’ contexts and includes academics, practitioners and intermediaries working with SMEs on Open Innovation.

Keywords: open innovation management modules,open innovation success stories,open innovation integrated toolbox,open innovation web platform,smes,open innovation players
HitSeed application for the Horizon 2020 dedicated SME Instrument - Phase 1 2014. September 2014. (HitSeedSME-1-09-14)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-12-01
End date: 2015-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HitSeed is conducting a feasibility study on their revolutionary Internet of Things (IoT) platform, which includes hardware, software, industrial design and software development tools. The platform is technologically novel, as it combines modern microcontroller-based hardware with touch display and graphical user interface providing unprecedented customer benefits, like low power consumption and significantly reduced unit cost. Most importantly, the IoT platform is disruptive, as it brings development costs down to completely new levels and shortens the IoT deployment time-to-market from 1-2 years to months or weeks while simultaneously reducing the risk level. It also allows the expansion of IoT solutions to domains that have not been feasible before, including e.g. mobile, "fire-and-forget" type of IoT sensor and monitoring devices. There is a clear customer need for our platform as many companies in Europe and globally struggle with finding a proper solution for their IoT needs or need to accelerate their product development to stay competitive. Potential customers vary from small startups developing consumer IoT products in various domains like household appliances or wellbeing to large enterprises needing a tested HW platform to boost their own product development e.g. for industrial clients. We estimate that the commercial potential for IoT devices based on our platform is 38 MEUR in 2017 with indirect impact being in the range of 600 new jobs in Europe, increased competitiveness of European industry, and an estimated customer value add of over 300 MEUR. During the feasibility study we are planning to do an IoT opportunity identification, build a business plan, develop a minimum viable product for IoT including an industrial design, as well prepare to pilot the solution with a first customer. The outcome of the study is a clear plan for the next steps including potential application for the phase 2 of the Horizon 2020 dedicated SME instrument funding

Keywords: hitseed,sme instrument,phase 1 september 2014
Nanomechanical spin-to-photon transduction in silicon (NAMESTRANSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The spin of an electron trapped in the binding potential of a phosphorous donor has recently shown some of the longest quantum coherence times in solid state and is now regarded as one of the most promising materials for quantum computing. However, current readout techniques rely on single-electron transistors for which millikelvin temperatures and nanoelectronic connections are needed. We propose to establish a new transduction mechanism that coherently couples silicon spin qubits to optical photons at the quantum level and hence provides optical addressing at 4K temperatures. Central to our proposed quantum transducer is a nanomechanical resonator, that acts as a conduit of quantum information. We will realize sufficiently strong interactions between the resonator and both spins and photons by exploiting nanophotonic systems, which can confine light fields and mechanical motion at the nanoscale. Our objectives are to show: (i) coupling between the spin and the mechanics by inducing spin-dependent mechanical frequency shift and read this out optically, and (ii) pulsed backaction-evading measurements of nanomechanical motion, establishing a fast single-shot qubit readout method, and allowing the creation of non-classical mechanical states through projective measurement. Doing this we create a unique three-way hybrid quantum system: spin qubit–mechanical resonator–optical cavity. The study of this new “spin-optomechanics” system is expected to both contribute to the exploration of the size-frontiers of quantum mechanics and lead to advancements in the field of quantum computation as well as ultra-sensitive magnetometry. The project allows the applicant to gain crucial expertise in nano-optomechanics and nanophotonics. Combined with his previous experience on spin qubits, the proposed research and the excellent scientific host environment will arm him with a unique skill set that will position him well for a future research position in Europe.
Dynamics of avian influenza in a changing world (DELTA-FLU)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Hong Kong,Belgium,Sweden,Netherlands,United States,United Kingdom,United Kingdom
Call: Understanding host-pathogen-environment interactions (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 5497793.75
EU funding (EUR): 5497793.75
Participants: 9
Project status: SIGNED

DELTA-FLU aims to determine the key viral, host-related, and environmental factors that determine the dynamics of avian influenza (AI) in poultry and other host species, with the goal of improving prevention and control strategies against this disease. As a result of rapidly changing dynamics, AI continues to cause unexpected and devastating outbreaks in poultry in the EU, as well as world-wide. Its potential to become pandemic is also of great concern to public health. The key viral, host-related, and environmental factors that drive AI dynamics are poorly understood, which currently impedes the development of effective control and prevention strategies. As the problems caused by AI require global solutions, DELTA-FLU is a consortium with top-level experts from Europe, North America, and Asia. Through interdisciplinary research focused on key questions of AI, DELTA-FLU will determine 1) potential for some highly pathogenic avian influenza viruses (HPAIV, e.g. H5N8 clade 2.3.4.4) to be maintained in wild bird populations and spread over long-distances, 2) key viral, host, and environmental factors for incursion of HPAIV from wild birds into poultry holdings, 3) roles of viral, host, and environmental factors in the transition of low pathogenic avian influenza virus to HPAIV in poultry, 4) effect of flock immunity against AI on early detection and viral genetic drift, and 5) viral genetic factors that allow reassortants of avian and mammalian influenza viruses to transmit efficiently among pigs. Primary sectors and end-users are involved through participation in the Multi-Actor Panel, which will also play an important role in the translation of the results into effective prevention and control strategies. As such, DELTA-FLU will make significant advances in knowledge of AIV dynamics and provide the evidence base for improved diagnosis, prevention, and control strategies for AI in poultry, as well as for reducing the possible risk of AI to become potentially pandemic.

Keywords: influenza,poultry,pigs,wild birds,biosecurity,viral evolution,interdisciplinary research,long distance spread,environmental niche,next generation sequencing,animal tracking
TARGETING ENDOTHELIAL CELL AND CANCER AMOEBOID MOVEMENT TO OVERCOME RESISTANCE TO ANTI-VEGF AND ANTI-PROTEASE THERAPIES (ENDOCAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-12-01
End date: 2021-09-01
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

Unlike mesenchymal migration, the amoeboid motility doesn’t require proteases and is an opportunistic movement of cancer cells which allows cells to glide through, rather than degrade, ECM barriers, using movements based on adaptations of the cell body. Preliminary experiments we conducted using a mixture of physiologic inhibitors of serine-proteases, metallo-proteases and cysteine-proteases, thus mimicking a physiological environment, showed no differences in vessel formation for both Endothelial Progenitor Cells (EPCs) and mature Endothelial Cells (ECs) under mesenchymal or amoeboid conditions. Thus, we hypothesized the existence of an “amoeboid angiogenesis”. We also hypothesized that the failure of cancer treatment using synthetic metalloproteinase inhibitors (MPIs) could be ascribed to the ability of cancer and ECs to skip the attack of the MPI therapy by allowing cancer invasion and blood vessel formation using the “amoeboid” strategy. Even the VEGFA targeting partially disregarded the expectations because of the resistance onset followed by the progression of the disease. Our preliminary experiments showed also an “indifference” of ECs and EPCs to VEGF stimulation under amoeboid conditions. Therefore, the aim of this project is to identify the multiple mechanisms shared by cancer cells and ECs/EPCs in the regulation of amoeboid movement, to identify common therapeutic strategies impairing vascular growth and cancer cell invasion at the same time, overcoming resistance to anti-VEGF and anti-protease therapy. The molecules identified (ephrin, protease receptors, etc.) will be used as candidates for targeted therapy through the delivery of cargo liposomes containing inhibitors of the connection of such molecules with the cortical actin cytoskeleton, in pre-clinical experiments with the perspective of a possible application to humans. We expect that this approach will give a progress in the treatment of tumors thus improving outcomes for cancer patients.

Keywords: angiogenesis,amoeboid movement,endothelial cells,endothelial progenitor cells epc,breast cancer,prostate cancer,acid sensitive liposomes,inhibiting peptides,sirna,mirna