Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable Glass Industry with Fuel-Flexible Technology (GIFFT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Lithuania,Sweden,Germany,United Kingdom
Call: Efficient and low-emission technologies for industrial use of combustion and gasification systems from low-value biogenic residues and wastes (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4478775.0
EU funding (EUR): 4478775.0
Participants: 9
Project status: SIGNED

Europe is the world leader in glass making, a highly energy-intensive industry that emits high amounts of CO2. The past century has seen improvements in the production process, but they are now approaching their limits. The objective of GIFFT is to develop a sustainable, hybrid, and biofuel flexible heat production technology and process that can be integrated into industrial glass manufacturing through efficient use of plasma-assisted combustion and gasification systems. An integrated heat production technology and process for glass manufacturing will be developed utilising biomass/waste and excess or cheap renewable electricity for syngas production, what will contribute to Europe’s progress and leadership for bioenergy integration into industrial settings. GIFFT will then develop and validate in an industrially relevant environment a fuel flexible entrained flow gasifier (EFG) with a novel e-gasification function and a new plasma-assisted fuel flexible gas burner for hybrid operation in glass furnaces. This will help diversify feedstock and improve the technological performance as well as cost reduction of bioenergy, ensuring a better circularity and increased use of renewables. The techno-economic feasibility and environmental impact of the technology will also be assessed to confirm that GIFFT contributes to an increased sustainability of biomass combustion and gasification and bioenergy value chains while reducing emissions.

Keywords: biofuel flexible system,hybrid furnace,biomass reuse,biogenic residues,entrained flow gasifier,e gasification,hybrid plasma assisted burner,ash recycling,combustion,glass making,low emission
VessEl noiSe effectS on balEen whaLe bioenergetics (VESSEL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 309951.36
EU funding (EUR): 309951.36
Participants: 2
Project status: SIGNED

Baleen whales are mega predators that shape the ecosystem structure and maintain healthy marine environments. A decrease in their populations can therefore have cascading trophic impacts detrimental to marine ecosystems they inhabit. The marine soundscape has dramatically changed since the Industrial Revolution. With increasing traffic, ship noise has become the most ubiquitous and pervasive source of anthropogenic noise in the ocean. Baleen whales rely heavily on acoustic cues for interpreting and exploring the marine environment. However, they hear best and produce sound at the same frequencies where cargo ships make the most noise, which makes them potentially the most sensitive species to vessel noise disturbance. Numerous studies have documented short-term adverse effects on baleen whales exposed to vessel noise, including changes in behaviour, and decreases and/or cessations in foraging. However, there is a lack quantitative data on i) the specific noise levels that trigger changes in behaviour, and ii) how these noise-induced behavioural changes impact the fitness of the exposed individuals. Through VESSEL, I propose to fill these important knowledge gaps by applying an innovative combination of state-of-the-art tagging technology and noise analysis to, for the first time in baleen whales, i) quantify received noise levels on the animal, and ii) estimate a dose-response relationship between vessel noise levels and the energy budget of the exposed individuals. The outcomes of VESSEL will be crucial to parameterize Population Consequence of Disturbance (PCoD) models that link disturbance parameters to fitness and population dynamics. Importantly, VESSEL will be of direct relevance to the management of underwater noise levels in EU marine waters by providing evident-based estimates of critical noise thresholds for the fitness of baleen whales that will set thresholds for Good Environmental Status (GES).

Keywords: marine mammals,cetaceans,biologging,foraging behaviour,noise disturbance,energy budgets,statistical modelling,acoustics
Prostate cancer diagnostics using a non-invasive test based on innovative glycan-based scanning (ProSCAN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Slovakia
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2021-10-01
End date: 2024-02-29
Duration (months): 29.0
Total project cost (EUR): 2839125.0
EU funding (EUR): 1987387.0
Participants: 1
Project status: CLOSED

Prostate cancer (PCa) is the 2nd most frequent cancer in men with 1.4M new annual cases and nearly 0.4M deaths worldwide in 2020. PCa incidence is expected to increase to 2.1M cases and 0.6M annual deaths by 2035. Statistically, 1 in 8 men will get PCa in their lifetime. However, nearly 50% of cancer deaths may be avoided if PCa were detected at early stages. Survival is proportional to the stage reached at the time of diagnosis - hence early-stage diagnostics is key to reduce mortality. Our aim is to clinically validate & register ProSCAN, an affordable, non-invasive next-generation liquid biopsy PCa diagnostic test with a final accuracy of up to 90%. The ProSCAN is the first test for early-stage PCa diagnostics based on glycan analysis in blood. ProSCAN will identify healthy men and those at risk of PCa, who need a confirmatory biopsy. Being so accurate, ProSCAN will eliminate ~1.6 M of avoidable biopsies with the cost of ~€1.5bn (in the EU and the US alone).

Keywords: early diagnostics,biotechnology,glycan based test,prostate cancer,health innovation,bionanotechnology
Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases (FIBROTARGET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Belgium,Spain,Germany,Italy,Greece,United Kingdom
Call: Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 5686450.0
EU funding (EUR): 5686450.0
Participants: 10
Project status: SIGNED

Fibrostenosis is the driving reason for the persistent need in bowel resections in inflammatory bowel diseases (IBD). Current IBD therapies are limited to solely targeting inflammation. While these therapies in some, but not all, cases lead to symptomatic disease remission, recurrent flares interspaced with periods of remission will still result in cumulative gut wall remodeling and fibrosis. Indeed, despite these therapeutic strategies to control inflammation, fibrostenosis incidence and bowel surgical resection is not declining in IBD patients, as no anti-fibrotic drugs are currently available. The aim of this project is to validate fibroblast therapeutic targets for preventing and/or treating fibrosis in IBD-patient-samples with an emphasis on C3 and/or Tyk2/STAT3 and/or NLRP3 in the evolution of intestinal fibrosis. The anti-fibrotic efficacy and mode of action of these novel immunotherapies will be studied preclinically in IBD-patient derived samples and validated in animal models of chronic colitis. In parallel, we aim to develop and validate a clinical diagnostic and prognostic pathway for fibrosis in IBD patients based on the use of non-invasive cross-sectional imaging techniques such as magnetic resonance enterography with elastography and optoacoustic. These results together will allow to design a first-in-human proof of concept randomized trial of immunotherapeutic drugs targeting complement C3 and/or Tyk2/STAT3 and/or NLRP3 pathways in intestinal fibrostenosis. Our aim is to obtain patients and regulatory approval for implementation of these novel non-invasive imaging modalities as diagnostic and prognostic tools for fibrotic IBD to allow vital future therapeutic development for intestinal fibrosis. By providing better molecular and clinical stratification of IBD patients at risk for fibrosis and by identifying and validating novel targets for anti-fibrotic therapy, we aim to pave the way in preventing and treating this invalidating IBD comorbidity.

Keywords: fibrosis,inflammatory bowel disease,crohn s disease,ulcerative colitis,intestinal fibroblast,stenosis,complement 3,tyk2,stat3,myeloid cells,nlrp3 inflammasomes
Solving holographic CFTs through the synergy of integrability and conformal bootstrap. (Bootstrability)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2026-10-01
Duration (months): 36.0
Total project cost (EUR): 284481.2
EU funding (EUR): 284481.2
Participants: 2
Project status: SIGNED

This proposal will develop innovative methods to access for the first time at non perturbative level the conformal field theory data of the two holographic conformal field theories that provides the best-established paradigms of the AdS/CFT correspondence: N=4 Supersymmetric Yang-Mills (SYM) and ABJM. This goal can be obtained combining the techniques of the conformal bootstrap, both in its analytical and numerical approaches, with integrability. Such methods proved to be very efficient when applied by themselves, and their complementary usage is the main novelty of this project. Considering that integrability provides a set of conformal data (the scaling dimensions), the plan is to use this piece of information as an input for the conformal bootstrap to compute the remaining set of data (structure constants). A strongly interdisciplinary approach, combining analytical and numerical conformal bootstrap together with the most advanced integrability methods, will be adopted to overcome the existing difficulties and compute those quantities. This will be possible thanks to the critical convergence of the expertise of the two supervising mentors and the researcher on different aspects of bootstrap and integrability. A crucial role will be played by novel techniques developed in recent years by the researcher. The new methods resulting from this action are expected to have a wide applicability, allowing the study of general correlation functions and to lead to quantitative answers to outstanding questions on AdS/CFT. The training plan is designed to boost significantly the researcher's scientific skills, as well as his teaching abilities with the delivery of two PhD level courses. The action involves a strong dissemination and outreach plan including scientific divulgation, a public lecture and the creation of a website/repository hosting permanent open-access resources for the scientific community, which will greatly facilitate further studies of holographic theories.

Keywords: conformal field theory,integrable models,conformal bootstrap,quantum spectral curve,ads cft
Gender Equality in Rural and Agricultural Innovation SystemS (GRASS Ceiling)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Norway,Spain,Sweden,Belgium,Croatia,Lithuania,Ireland,Netherlands,Italy,United Kingdom
Call: Boosting women-led innovation in farming and rural areas (HORIZON-CL6-2022-COMMUNITIES-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2817498.75
EU funding (EUR): 2817498.5
Participants: 27
Project status: SIGNED

GRASS Ceiling will develop a context where women can drive socio-ecological transitions, that is, develop innovations in response to socio-ecological challenges and strengthen the resilience of rural areas. This is essential to deliver the UN’s goals on gender parity, realise the EU gender equality strategy, and achieve the goals of the Green Deal, the Farm to Fork strategy, the Long-Term Vision for Rural Areas and the European Pillar of Social Rights. GRASS CEILING is a multi-actor project that will increase women-led socio-ecological innovations in farming, the rural economy and in rural communities (i.e., smart-agri skills, eco-tourism, pasture led agriculture, organic cheese, energy neutral village halls, community gardens, elderly care cooperatives). Socio-ecological innovation in farming and rural areas is a developing area in Europe, and GRASS Ceiling will co-create tools to ensure women can fully participate. Our consortia include end-users (women innovators), stakeholders and researchers in case study Member States, as well as European bodies and stakeholders who can influence EU policy such as the EU Women’s Entrepreneurship Platform (WEP), Copa-Cogeca (EU representatives of farmers and agri-cooperatives), The European Association for Information on Local Development (AEIDL), and the European Environmental Bureau (EEB). GRASS Ceiling brings together leading academic partners with many years of experience in research and practice projects that seek to empower and support women in agriculture and rural areas throughout a variety of contexts in Europe. The project involves women-innovators on farms and in rural areas who will participate in our 9 socio-ecological women innovator living labs in 9 case study countries. Our Living Labs are practical, women-led, interactive innovation initiatives that will increase knowledge and provide tools to assist women innovators and policy and support organisations at Member State and EU level.

Keywords: women socio ecological innovators,inclusive policies,positive change
Global Strategy for Skills, Migration, and Development (GS4S)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Switzerland,United Kingdom,Bangladesh,Italy,Austria,Egypt,Nigeria,Estonia
Call: Global Shortages and Skill Partnerships (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2877781.25
EU funding (EUR): 2877781.25
Participants: 14
Project status: SIGNED

In light of EU challenges relating to an aging workforce and the energy transition, the EU faces a shortage of relevant skills. GS4S seeks to better understand global skills shortages in selected sectors (Digital, Care and Construction) and strengthens evidence-based policies through new evidence on various overlooked global mobility schemes. Uniquely, a business perspective at macro, meso and micro levels is central to the proposal, juxtaposing local strategies for filling skills shortages of Multinational Enterprises and Small- and Medium Enterprises in global value chains. Moreover, we focus on skilled (migrant) workers experiences with skilling, upskilling and reskilling in EU and non-EU regional contexts. We propose multi-level policies on labour migration governance and alternative ways for addressing these shortages in the six regions (EU, EEA, Western Balkan, Middle East and Northern Africa, West Africa, and South/South-East Asia). Using mixed-methods research, the interdisciplinary consortium (with partners in Austria, Belgium, Estonia, Italy, Netherlands, Switzerland, Egypt, Nigeria, and Bangladesh) aims to provide exploitable datasets and practical tools for policy makers, businesses, and educational institutions in the EU and non-EU countries towards improved matching of skills to address labour market needs. In doing so, the project aims to contribute to a socially sustainable (well-being oriented) global strategy for skills, migration and development.

Keywords: skilled migration,talent partnerships,multinational enterprises,global value chains,human resource management,trade in services,intra eu mobility,skills and development,social sustainability
The INscribed city: urban structures and interaction in ROME (IN-ROME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Italy,Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2498457.0
EU funding (EUR): 2498457.0
Participants: 3
Project status: SIGNED

Rome as the first-ever mega-city reaching c.1 million inhabitants in the early empire (1st cent. BCE), remains an enigma regarding the way it organised itself and maintained that size for over three centuries. Having long outgrown the 4th-cent. BCE city walls, the urbanistic structures that developed outside of these, and especially outside the later Aurelian Wall, have never been studied systematically and holistically. IN-ROME aims to fill this fundamental gap. It will describe for the first time how different parts of the population (ethnicities, status groups, genders) and their activities map onto the city’s surroundings via military stations, association seats, sanctuaries, production sites, mines, agriculture, retail, baths, guesthouses, tombs and villas. Translating topographical relations into social ones, it aims significantly to enhance our understanding of the city’s social fabric. Methodologically, IN-ROME breaks new ground by unlocking the enormous potential of inscriptions for our understanding of Rome’s urban development and social fabric through virtual re-contextualisation and statistical analysis. The authoritative Epigraphic Database Roma will be extended to include all Latin and Greek inscriptions with known or probable provenance (totalling c.50,000). They will be linked to Rome’s most sophisticated Digital Archaeological Cadastre, SITAR, via a newly created map layer of 17th-20th-cent. properties (the main historic reference to location). These new resources will allow the exploration of topographical patterns of activities on an unprecedented scale, revolutionising access to a vast pool of historic information and restoring Rome’s people back into their landscape. Outputs include six books and two international conferences with proceedings. The geo-referenced inscriptions and historic property map will be lasting resources beyond this project, and will radically transform a wide range of research from multiple disciplines.

Keywords: roman history roman archaeology epigraphy gis databases city of rome
Regreening Africa with natural regeneration (REACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499694.0
EU funding (EUR): 1499694.0
Participants: 1
Project status: SIGNED

The challenge. With 65% of agricultural land in Africa degraded, the need to effectively scale up restoration is evident. Natural regeneration (NR) is a promising restoration solution that depends on vegetation regrowing from seed or tree stumps, without the need to plant trees. However, we do not know what regenerates where and what benefits it may bring. What we do know comes from ecological studies on secondary succession that exclude human influences. This informs restoration poorly since people continuously use, manage and control NR. Aims. This study aims to 1) evaluate how NR develops over time and what benefits it brings, to 2) explore the optimal social-ecological conditions for NR-based restoration, and 3) predict the current and future NR restoration potential across Sub-Saharan Africa. Approach. Recent scientific breakthroughs in succession ecology and on-the-ground restoration developments offer exiting opportunities to gain new mechanistic insights into NR dynamics. I will: 1) Monitor woody vegetation in 150 unmanaged and managed agricultural fields across three ecoclimatic zones in Kenya. 2) Measure plot-level environmental and social variables that affect species performance. 3) Employ a trait-based approach to evaluate the relative importance of different regeneration mechanisms and consequences for multiple ecosystem functions. 4) Scale up mechanistic insights using large datasets and identify regional drivers of NR abundance, functional composition and diversity. 5) Predict climate change effects on NR and map current and future NR restoration potential across Sub-Saharan Africa. Impact. I will develop a mechanistic social-ecological framework for NR by integrating social dimensions into ecological theory, which allows to predict how NR contributes to restoration and where it may need to be complemented with tree planting. This is vital for effectively scaling up restoration during the current UN decade on ecosystem restoration.

Keywords: secondary succession,agroforestry,functional traits,farmers,social ecological systems,restoration