Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Point-of-care molecular diagnostics of psoriasis and eczema – peLabDisk (peLabDisk)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-03-01
End date: 2019-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Innovative and effective biological therapies exist to treat non-communicable inflammatory skin diseases (ncISD). However, diagnostic guidance when and how to use them is imprecise; no substantial innovation was made for decades. Due to this lack of innovation, high socio-economic costs are caused by ineffective unguided treatment – a waste of resources. Existing ERC research aims at establishing individualised medicine in ncISD (IMCIS, grant agreement 676858). First success is a biomarker to distinguish psoriasis from eczema. Due to disease heterogeneity, these two ncISD cannot be distinguished in 10% of all cases with current gold standard diagnostics. Treating patients with the wrong therapy as a consequence of mis-diagnosis is inefficient and might even be harmful. This PoC proposal follows the path of IMCIS and closes the gap between ERC research and a prototype device of a point-of-care microfluidic testing device to distinguish psoriasis and eczema based on their molecular signature (peLabDisk). The proposal is feasible, as there is a high level of expertise created by joint forces of researchers of the Technical University of Munich and Hahn-Schickard providing extensive competence in the development, construction and manufacturing of microfluidic cartridges for medical applications. The project plan consists of well-defined work packages and milestones. Furthermore, success of the individual work packages is supervised by experienced experts (TUM Entrepeneurship). This PoC proposal is not the end – there is a clear roadmap and a detailed strategy for the post-PoC phase including potential end-user network and supported foundation of a spin-off company. peLabDisk represents the first approach of molecular diagnostics in the field that is easy-to-handle, robust and valid, as well as economic. It is superior to current gold standard diagnostics. Furthermore, peLabDisk is a use-case for point-of-care molecular diagnostics in complex inflammatory diseases.

Keywords: non communicable inflammatory skin diseases,psoriasis,eczema,lab on a chip,molecular diagnostics,microfluidics,point of care
Cross-talk between skeletal muscle and pancreatic islets: impact of exosomes (ExoDia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-02
End date: 2020-01-01
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The worldwide explosion of obesity has resulted in an ever-increasing prevalence of type 2 diabetes (T2D), a non-communicable disease that affects more than 370 million people worldwide. T2D is characterized by insulin resistance with a relative deficiency in insulin secretion. It is now recognized that there is decreased beta-cell function and mass in T2D but the precise underlying mechanism remains to be determined. Skeletal muscle accounts for >50% of the total glucose uptake in the post-prandial state, it is also the largest organ in non-obese individuals. Recent studies demonstrated that there is conversation between skeletal muscle and beta-cells, and that certain peptides (i.e. myokines) secreted by insulin-resistant skeletal muscle cells may impact negatively on beta-cell function, proliferation and survival in T2D. Nevertheless, other factors than myokines could also be involved in this inter-organ communication. A novel concept suggests microvesicles, such as exosomes, as a new cell-to-cell communication mode. The major goal of the project will be to characterize the different exosomes populations and their impact on islets cells. The findings may have important implications for understanding decreased functional beta-cell mass in diabetes, especially in T2D etiology, and therefore bring new insights into the development of innovative therapies. To achieve the aims of the innovative translational project, the candidate will be part of one of the European leader research centres on diabetes, trained to promising new research area in inter-organ communication, micro-RNA biology, as well as cutting-edge 'omic' technologies which will perfectly complement her strong knowledge in energy metabolism and physiology and create a rare expertise in candidate's profile. It will provide a unique stepping-stone for her independent research career in Europe and successful collaborations in the future.

Keywords: type 2 diabetes,insulin resistance,skeletal muscle,beta cells,inter organ communication,exosomes,myokines,metabolism,exercise
New generation of polymeric films, LDPE-Graphene based, for industrial applications (GRAPHCOAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Barrier coatings and films are essential in many industries – like food/medical packaging, building or textiles – as a protection from moisture and bacteria, corrosion, heat, physical damage... However, the materials currently in use often offer a limited performance (e.g. plastics are not completely impenetrable), present a risk for human health and the environment (many metals and solvent-based coatings widely used as protective barriers are increasingly regulated for their toxicity) and/or show a growing trend of supply scarcity and price rise (unstable remote metal ores). A new generation of effective coating materials, eco-friendly and economically viable, is therefore urgently needed to improve the protection and safety of consumer and industrial goods. Taking up this challenge, we present GRAPHCOAT, a ground-breaking multifunctional barrier film made of Low-Density Polyethylene (LDPE) enhanced with high-quality and non-toxic graphene nanoplatelets and manufactured with our proprietary extrusion coating technology. Through its unique compound formulation and exploiting the unparalleled features of graphene, GRAPHCOAT offers outstanding barrier properties, excellent mechanical strength, heat dissipation and UV absorption properties, among others. It allows a longer life for consumer goods, enhanced food and medical safety, and require less raw material compared to current barrier technologies. Roncoroni is an Italian family-owned company with more than 50 years of experience in the lamination and coating field, and a consolidated customer base. Our new product has already raised the attention of many of our clients in the fields of industrial packaging, building insulation and protective clothing. Thanks to GRAPHCOAT, they will benefit from a last-generation, high-performance and sustainable range of products in their offering, that will lead them to long-term profitability. We, in turn, expect to reach +€13.7M revenues and hire 16 new people by 2025.

Keywords: low density polyethylene,ldpe,graphene,graphene nanoplatelets gnps,multifunctional,protective coating,barrier,extrusion coating,nanocomposite,packaging,protective clothing,insulation
Regulatory Approved Software for Mutation Analysis in Cancer (RASMAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As the incidence and prevalence of cancer increases worldwide, advanced anti-cancer drugs have become one of the key cost centres in healthcare budgets. This is a major societal challenge for the EU and global decision makers. Nowadays, modern anti-cancer therapies are expensive and are based on mutation analysis of cancer DNA Next-Generation-Sequencing data. However, state-of-the-art software used to analyse this data lack diagnostic accuracy and regulatory approvals. Oncodia aims to address this market gap by developing RASMAC – software for analyses of tumours DNA sequencing data - to optimise the use of targeted anti-cancer therapies. The most innovative aspect of RASMAC lies in the deterministic algorithms that make it possible to accurately identify cancer mutations. We aim to set a new standard for diagnostic accuracy in mutation analysis in cancer that will lead to the right therapy for every patient. Oncodia is well-positioned to disrupt the underserved market for cancer mutation analysis because of the expertise of multi-skilled team and the quality of previous projects (EU FP7 INNOVATION). Oncodia is the company able to uniquely deliver technologically superior, regulatory approved and cost-effective software. The innovativeness of our product has been recently confirmed through "Attractive Innovation Project Award" from Uppsala University Innovation. During the Phase 1 Project, Oncodia will develop a business plan for the development and commercialisation of RASMAC. Specific objectives of this project are to design a study to improve the performance of the product and to conduct a market feasibility assessment to optimize go-to-market plan. The Phase 1 project is an important step on Oncodia’s journey to facilitate access to better DNA-based diagnostic routines for cancer patients worldwide. If successful, the project will take Oncodia to a new level of competitiveness and growth.

Keywords: software as a medical device,detection of cancer mutations,next generation sequencing data analysis
March-on-in-Time: Boundary Element Time-Domain Domain Decomposition Methods (BET3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999900.0
EU funding (EUR): 1999900.0
Participants: 1
Project status: SIGNED

Modelling almost entirely replaced prototyping as a design methodology. In electromagnetics and optics, it has played a central role in the rapid development of communication and imaging, with applications in medicine, security, and energy. New technological requirements have always been met by breakthroughs in modelling. Advances in THz technology have driven researchers to consider systems that are highly non-linear and strongly radiating. Modelling these systems requires methods that are based on time-stepping, and that can accurately describe unbounded regions. These requirements can only be met by time-domain boundary element methods (TD-BEMs). The use of other methods such as the finite element method, the method of moments, or the finite difference time-domain method – if at all applicable – results in unacceptable computational costs, and large errors in dispersion and radiation characteristics. Unfortunately, TD-BEMs are not nearly as mature as other methods. They lack the ability to model all but the simplest systems. Attempts to use TD-BEMs to model realistic devices containing multiple materials, ports, coatings, or two-dimensional materials like graphene lead to instabilities, rendering the result of simulations completely useless. This state of affairs has persisted for over 50 years but has become an urgent problem now. BET3D will aggressively accelerate the development of the time-domain boundary element method into a method that can model highly non-linear, strongly radiating systems and that unlocks the capability to model emerging technologies in THz communications and imaging, and beyond. As part of the benchmarking and validation for this project, we will model the generation of THz radiation by an array of graphene resonant tunnelling diode oscillators, including feeds, ports, packaging, and antenna structure. Results of BET3D will enable modelling of non-linear, radiating systems, also in acoustics, elastodynamics, and fluid dynamics.
A Large-Scale Systems Approach to Flood Risk Assessment and Management (SYSTEM-RISK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Austria,Italy,Italy,Germany,Italy,Germany,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3884131.08
EU funding (EUR): 3884131.08
Participants: 18
Project status: CLOSED

Flood risk systems are characterised by physical and socio-economic processes acting at different space-time scales, by non-stationary and non-linear behaviour, and by a significant degree of interdependence between processes. This may lead to surprising developments and unanticipated side effects of risk reduction measures. A novel systems approach is needed that captures this dynamics and accounts for the interactions of the system components. We propose the ETN SYSTEM-RISK which aims at developing this systems approach for large spatial scales, from large river basins to the European scale. The research concept of SYSTEM-RISK builds upon the entire risk chain, from the source of hazard to consequences, and analyses the interactions and temporal dynamics in flood risk systems. In this way, the linear risk chain is replaced by a more realistic approach with interdependent links. SYSTEM-RISK exposes early-stage researchers (ESR) to all knowledge domains along the risk chain, and gives them, at the same time, the opportunity to build specific research profiles. The interdisciplinary setting and the focus on interactions and spatio-temporal dynamics of risk system will expand the mental models and lead to a new generation of creative scientists, able to transfer their systems perspective from flood risk systems to other fields. We bring together internationally leading groups in flood research with institutions from the non-academic main sectors exploiting flood research – consultancy, insurance industry and governmental sector. Close interaction will support the ESRs in developing trans-disciplinary skills with an understanding of both fundamental science and application. SYSTEM-RISK will deliver a suite of methods and tools for assessing and managing flood risk across large regions. This will be of highest importance for the EU Flood Directive and Strategy on Adaptation for Climate Change due to the EU’s key role in dealing with risks transcending national borders.

Keywords: floods,inundation,extreme events,catchments and river systems,flood defence failure,risk analysis,risk management,hazard,vulnerablility
Bringing down costs of BIPV multifunctional solutions and processes along the value chain, enabling widespread nZEBs implementation (BIPVBOOST)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Italy,Germany,Spain,Italy,Switzerland,Switzerland,Belgium,Belgium,Belgium,France,France,France,Netherlands
Call: Demonstrate significant cost reduction for Building Integrated PV (BIPV) solutions (H2020-LC-SC3-2018-RES-SingleStage, 2018)
Start date: 2018-10-01
End date: 2023-05-31
Duration (months): 56.0
Total project cost (EUR): 11434538.75
EU funding (EUR): 8844070.14
Participants: 21
Project status: SIGNED

Building-integrated photovoltaic (BIPV) technology has the potential to significantly contribute to the achievement of the demanding energy efficiency targets set by the EU, however, its market uptake has been hindered in the past years by the difficulties of the industry in providing holistic solutions complying with key demands from decision makers and end-users. In this sense, it is a common perception that a joint industrial effort is needed to conceive and develop highly-efficient and multifunctional energy producing construction materials, in order to provide market opportunities at a world-wide level for the European photovoltaic and construction industry value chains. This market deployment depends critically on the achievement of ambitious targets in terms of significant cost reduction, flexibility of design, high performance, reliability in the long-term, aesthetics, standardization and compliance with legal regulations. Within this context, the main objective of BIPVBOOST project is to bring down the cost of multifunctional building-integrated photovoltaic (BIPV) systems, limiting the overcost with respect to traditional, non-PV, construction solutions and non-integrated PV modules, through an effective implementation of short and medium-term cost reduction roadmaps addressing the whole BIPV value chain and demonstration of the contribution of the technology towards mass realization of nearly Zero Energy Buildings. In order to address these global objectives and maximize the impacts, the project will optimally combine and demonstrate in real operation conditions: (i) a completely flexible and automated BIPV manufacturing and control line, (ii) a large portfolio of multifunctional BIPV products optimally integrated in the building envelope, (iii) process and energy management innovation based on digitalization and (iv) advanced standardization activities supporting the qualification of BIPV systems for a massive implementation in the building skin.

Keywords: bipv,value chain,cost redution,nzeb targets
Smart End-to-end Massive IoT Interoperability, Connectivity and Security (SEMIoTICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Spain,Germany,Poland,Greece,Switzerland,Denmark
Call: R&I on IoT integration and platforms (H2020-IOT-2017, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 4995915.0
EU funding (EUR): 4995915.0
Participants: 10
Project status: CLOSED

SEMIoTICS aims to develop a pattern-driven framework, built upon existing IoT platforms, to enable and guarantee secure and dependable actuation and semi-autonomic behaviour in IoT/IIoT applications. Patterns will encode proven dependencies between security, privacy, dependability and interoperability (SPDI) properties of individual smart objects and corresponding properties of orchestrations involving them. The SEMIoTICS framework will support cross-layer intelligent dynamic adaptation, including heterogeneous smart objects, networks and clouds, addressing effective adaptation and autonomic behaviour at field (edge) and infrastructure (backend) layers based on intelligent analysis and learning. To address the complexity and scalability needs within horizontal and vertical domains, SEMIoTICS will develop and integrate smart programmable networking and semantic interoperability mechanisms. The practicality of the above approach will be validated using three diverse usage scenarios in the areas of renewable energy (addressing IIoT), healthcare (focusing on human-centric IoT), and smart sensing (covering both IIoT and IoT); and will be offered through an open API. SEMIoTICS consortium consists of strong European industry (Siemens, Engineering, STMicroelectronics), innovative SMEs (Sphynx, Iquadrat, BlueSoft) and academic partners (FORTH, Uni Passau, CTTC) covering the whole value chain of IoT, local embedded analytics and their programmable connectivity to the cloud IoT platforms with associated security and privacy. The consortium is striving for a common vision of creating EU’s technological capability of innovative IoT landscape both at European and international level.

Keywords: localized analytics,smart behavior,smart sensing,smart actuation,industrial internet of things,iiot security and privacy
Particles in Greek and Hittite as Expression of Mood and Modality (PaGHEMMo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

This proposal investigates the original meaning and uses of the particles án and ken in the earliest Greek texts (epic and lyric poetry and inscriptions, VIII-VI BC, there are no examples in Mycenaean, XIII BC) and their interaction with mood and modality, the use of the particles man, san and kan in the Old-Hittite texts (1650-1450 BC) and the comparison between the particles in Greek and Hittite, and to what extent the subordination plays a role in the use of the Greek particles. The use of the modal particle án with the different moods is strictly regulated in Classical Greek (V-IV BC), but epic and lyric Greek, and other dialects án, use ken or ka, and the rules seem less rigid. So far no study addressed the use of these particles in the oldest Greek texts. I gather the data, determine if they are secured by the metre, tag and catalogue them per tense, mood, type of sentence (negative, affirmative, main clause, subordinate and type of subordinate clause) and type of text (narrative, speech) and analyse the use(s). While Greek has a rich system of moods and particles, Hittite has only two moods and conveys the non-realis meaning through the particle man, but also san and kan can specify the verb. Kan is said to be related to ken and becomes the default particle in later texts replacing san, but in Old-Hittite texts san is more common. The original meaning of san and kan is debated. I gather the instances of kan and san, catalogue them per text and sentence type, and investigate the meaning. Then I compare the use of these particles with verbs to Greek ken. Finally, I investigate the link between the Greek particles and subordination. The particles are attested more in subordinate than in main clauses and in some subordinate clauses they are used more often than in others. There are two questions: were the particles used as subordination markers or can the paratactic origin of the subordinate constructions explain their use.

Keywords: epic greek,historical syntax,indo european,hittite,historical linguistics