Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Massive reutilization of Electronic Health Records (EHRs) through AI to enhance clinical research and precision medicine (SAVANA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Spain,France,United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2022-07-31
Duration (months): 45.0
Total project cost (EUR): 2408995.78
EU funding (EUR): 1262520.0
Participants: 4
Project status: CLOSED

In the last twenty years, the average return on R&D expenditure in the pharma industry has dropped from almost 18% to 3.7%. Moreover, annual funding for biomedical research has more than doubled while new drugs approvals have declined by one third. There is a wide consensus that the main cause of this problem is the exhaustion of a model intended to develop ‘broad indications’ and the need for a new ‘precision medicine’ model. We simply do not know enough about the underlying disease mechanisms involved, and more research is required to develop better disease classifications, which will enable a more targeted development approach for drugs and therapies. Electronic Health Records (EHRs) has been used for more than ten years in most developed countries, and they gather now exhaustive clinical information of millions of patients. Leveraging EHRs could accelerate clinical research, and improve healthcare quality. However, in order to uncover unknown disease models from EHRs, precision medicine requires massive research studies on thousands of patients (often in several countries). Currently there is no tool capable of: 1) automating the extraction of data from EHRs, and also, solving the privacy concerns raised by EHRs. SAVANA RESEARCH uses Natural Language Processing to extract data from massive amounts of EHRs’ clinical narratives. It has the following advantages intended to make a leap in clinical research efficiency: 1) It uses only de-identified clinical records and ensures state of the art technologies to protect data privacy; 2) It is capable of decoding ten times more EHRs in half of the time; 3) It is capable of identifying 100 times more variables from EHRs; 4) And it costs 40% less. The application of NLP to healthcare is a fast-growing market that is expected to reach 2.65 billion by 2021, by growing at a CAGR of 20.8%. SAVANA RESEARCH’s target markets are primary Europe and North America, which together comprises 75% of all clinical trials worldwide.
EXPLORING NONLINEAR DYNAMICS IN GRAPHENE NANOMECHANICAL SYSTEMS (ENIGMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 1422598.0
EU funding (EUR): 1422598.0
Participants: 1
Project status: SIGNED

Micro and nanomechanical systems are being adopted in billions of products, that address a wide range of sensor and actuator applications in modern technology. The advent of graphene, and the ability to fabricate single atom thick membranes, promises further device downscaling, enabling ultimate sensing capabilities that until recently seemed utopical. But, these atomically thin membranes are in essence nonlinear and exhibit nonlinear dynamic behavior at forces of only a few pN, which needs to be understood to harness their full potential. Although the field of nonlinear dynamics dates back several centuries, its implications at the atomic scale have remained relatively unexplored. Thermal fluctuations due to Brownian motion and nanoscale forces become dominant at this scale, and when combined with graphene’s exotic elasticity, give rise to phenomena that are not observed before, and cannot be explained by classical approaches. Our poor understanding of these complex features at the same time, have made characterization of graphene very challenging. An example is its bending modulus that is evaluated orders of magnitude higher than theoretical predications, by the available experimental methods. In this project, I aim at providing full understanding of nonlinearities of these one atom thick membranes, not only to unveil the enigmatic behavior of graphene but also to improve current nanomaterial characterization methods. The distinguishing feature of my methodology is that on the one side, it will be based on atomistic simulations combined with modal order reduction techniques, to predict the complexities at the single atom level; on the other side, experimental nonlinear dynamic data will be analyzed for evaluating nonlinear effects and extracting material properties using nonlinear resonances in the MHz range. My methodology will have the potential to serve as the next generation of characterization techniques for nanomaterial science and nanomechanics communities.

Keywords: nonlinear structural dynamics,atomically thin membranes,reduced order modelling,experimental dynamics,nonlinear system identification,nano electromechanical systems
HIV-1 sensing and signaling in dendritic cells (SENTINEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 2499156.25
EU funding (EUR): 2499156.0
Participants: 1
Project status: CLOSED

HIV-1 is a major global health problem with over 2 million new infections every year, and although antiretroviral therapy is effective, chronic infected patients suffer from severe co-morbidities due to immune dysfunction. With the proposed SENTINEL project, I aim to identify novel strategies to enhance innate antiviral immunity to HIV-1 to limit establishment and progression of chronic disease. Our novel data strongly suggest that induction of antiviral innate immune responses in dendritic cell subsets delays disease progression and improves survival in chronic HIV-1-infected patients. Current paradigm suggests that HIV-1 evades innate sensing in dendritic cells and that this underlies immune dysfunction. However, our innovative data demonstrate that HIV-1 actively suppresses a novel innate sensing mechanism and antagonizing this HIV-1 suppression by drugs strongly enhanced antiviral immunity. Strikingly, we identified a gene polymorphism in a component of the novel HIV-1 sensing machinery, rendering the pathway insensitive to HIV-1 suppression; this polymorphism is associated with delayed disease progression and improved survival in HIV-1 patients from the Amsterdam Cohort Studies. Thus, I hypothesize that therapies counteracting the suppression by HIV-1 will enhance antiviral immunity and restore immune dysfunction in chronic patients. Within this SENTINEL project, novel targets for HIV-1 therapy will be identified. As we identified proto-oncogenes involved in the suppression of innate immune responses by HIV-1, we will also screen clinically approved anti-cancer drugs as novel therapies to enhance the innate immune responses to HIV-1. Our exciting data strongly underscore the innovation and feasibility of the project. The unique expertise of my group in elucidating complex mechanisms that shape immunity, our innovative ex vivo human tissue infection models and cohort studies will be crucial in the proposed research and paramount to its success.

Keywords: hiv 1,dendritic cell,pattern recognition receptor,adaptive immunity
New ElectroSTATIC Spraying Process of Two-Component, Solvent-Free, Fast-Curing, Liquid Resins (KEMISTATIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: France
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2021-12-31
Duration (months): 45.0
Total project cost (EUR): 2091711.0
EU funding (EUR): 1464197.7
Participants: 1
Project status: CLOSED

Water-based coatings lead the coating demand worldwide. However, they present some drawbacks (poor durability and resistance to corrosion). Powder coatings have better durability and performance, but still present important disadvantages: They contain hazardous compounds (Bisphenol A) and require a curing step in oven (200ºC) that makes them energetically costly and not suitable for substrates like wood and EPS or big objects/infrastructures, like bridges or wind turbines. In addition, they have poor aesthetic value. KEMISTATIC is a disruptive, environmentally friendly and patented coating technology, which aims to replace the conventional powder coating and liquid paint coating systems. It is based on the electrostatic application of resins that are free of solvent, Bisphenol and VOCs (volatile organic compounds). KEMISTATIC provides enhanced protection (corrosion, wear resistance, electrical insulation) and aesthetic potential, at a lower production cost (up to 5 times) and sale price (up to 3 times), and not requiring a curing step in oven. Thus, KEMISTATIC overcomes the substrate limitation and is suitable for a wide range of materials and on-site application, while requiring a low initial investment (€150,000). During ph 2 project we will optimize our prototype of the electrostatic spraying system and the resins for different applications. Finally, once the equipment is validated at industrial scale, selected end-users will test it. KEMISATIC can be used in many industries (Automotive, Architectural, Furniture, etc.), and save up to €180,000/year/job coater and 150m3/hour of gas emissions. We aim to reach worldwide markets, starting in Europe, then North Africa and Asia and finally US and the Rest of the World. In this way, KEMISTATIC project will have a remarkable economic impact on our Company (ROI of 5.11 by 2023), and contribute to increase our competitiveness, by targeting new markets and increasing our international presence.

Keywords: coating,electrostatic,solvent free,energy saving,vocs,bisphenol a
Advanced multi effect device to prevent fruit and vegetables ripening (DURAFRESH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SME Bolaseca has developed an energy-free consumption device that restrains fruit and vegetables ripening. This innovation can be used all along value chain, from crops recollection to final domestic consumer. Durafresh´s installation is simple and flexible; adaptable to any need depending on the current conditions of each user. An easy calculation will determine the number and size of devices required in each case. According to 2017 FAO´s report there is a 45% fruit and vegetable food losses. Along with roots and tubers, fruit and vegetables have the highest wastage rates of any food products; almost half of all the fruit and vegetables produced are wasted. Durafresh patented solution has very low investment barrier and lower cost maintenance as market standards, making it attractive for starting the use of it. This device has a high demonstrated performance so far, and meets EU consolidated (in 2017) recommendations on food waste field. Bolaseca pretends to enter the food market with its sound and demonstrated solution.

Keywords: business model,big growth,fruits and vegetables,market opportunities,whole chain value,innovative patented proposal
The Quantum Geometric Langlands Topological Field Theory (QuantGeomLangTFT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2021-05-31
Duration (months): 72.0
Total project cost (EUR): 1100947.5
EU funding (EUR): 1100947.5
Participants: 1
Project status: CLOSED

We will use modern techniques in derived algebraic geometry, topological field theory and quantum groups to construct quantizations of character varieties, moduli spaces parameterizing G-bundles with flat connection on a surface. We will leverage our construction to shine new light on the geometric representation theory of quantum groups and double affine Hecke algebras (DAHA's), and to produce new invariants of knots and 3-manifolds. Our previous research has uncovered strong evidence for the existence of a novel construction of quantum differential operators -- and their extension to higher genus surfaces -- in terms of a four-dimensional topological field theory, which we have dubbed the Quantum Geometric Langlands (QGL) theory. By construction, the QGL theory of a surface yields a quantization of its character variety; quantum differential operators form just the first interesting example. We thus propose the following long-term projects: 1. Build higher genus analogs of DAHA's, equipped with mapping class group actions -- thereby solving a long open problem -- by computing QGL theory of arbitrary surfaces; recover quantum differential operators and the (non-degenerate, spherical) DAHA of G, respectively, from the once-punctured and closed two-torus. 2. Obtain a unified construction of both the quantized A-polynomial and the Oblomkov-Rasmussen-Shende invariants, two celebrated -- and previously unrelated -- conjectural knot invariants which have received a great deal of attention. 3. By studying special features of our construction when the quantization parameter is a root of unity, realize the Verlinde algebra as a module over the DAHA, shedding new light on fundamental results of Cherednik and Witten. 4. Develop genus one, and higher, quantum Springer theory -- a geometric approach to constructing representations of quantum algebras -- with deep connections to rational and elliptic Springer theory, and geometric Langlands program.

Keywords: topological field theory,geometric langlands,quantum groups,character varieties,a polynomial,double affine hecke algebras,mapping class groups,braid groups,knot invariants
Digital Health Hub Europe (IDH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project objective is to understand the market feasibility of a new, technology enabled healthcare delivery model that is currently being piloted in Birmingham, U.K with encouraging initial results. The project will develop the understanding needed to subsequently pilot this disruptive healthcare innovation in other parts of the U.K. and Europe – essentially providing the market intelligence and understanding to start to take the innovation from ‘niche to mainstream’. The European Digital Health Hub presents a radical new model for delivering healthcare to a growing and ageing healthcare population, who have an increasing number of healthcare needs and long-term conditions. The hub addresses the requirement for providing more efficient care for less money, in response to both economic and healthcare demand challenges. The Hub places the citizen at the centre of the delivery of healthcare through a new, technology enabled healthcare model – delivered in primary, community care, home and mobile settings. It creates an opportunity for radically different models of healthcare to be developed in partnership with local providers across Europe. It disrupts existing healthcare markets by shifting care away from Acute settings, improving services for patients and delivering better services at lower than tariff rates, thereby saving money to commissioners/payers overall whilst delivering integrated, sustainable and citizen-centered care. The specific project outcome, will be a qualified business case with early adoption partners, to undertake a series of delivery pilots in other areas of both the U.K. and Europe.

Keywords: integrated digital health solution
Mechanics with Molecules (MEMO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Belgium,France,France,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2022-03-31
Duration (months): 54.0
Total project cost (EUR): 3997843.75
EU funding (EUR): 3997843.75
Participants: 7
Project status: CLOSED

In this project, single molecule-machines will be constructed and tested on a surface and one at a time, controlling the rotation and the work delivered by a single molecule-motor directly at the atomic scale. The molecule motors and gears, designed and tested by MEMO, will be further adapted to applications requiring collective and synchronous motion. The MEMO partners will design molecular motors and gears able to perform collective and synchronous motion. They will test the rotation of such molecule-gears step-by-step according to their chemical composition, the structure of their teeth, their rotational axle, and the supporting surface. MEMO will design molecule-motors adapted to transmit single molecule motion from the atomic scale to the mesoscale (and beyond). In MEMO, low-temperature UHV experimental methods including scanning tunneling microscope and four independent scanning probe microscopes on the same surface will be used, as well as atomic force microscope in solution. MEMO will explore how a molecule-gear with ~1 nm diameter can mechanically match a nanofabricated solid-state nano-gear with ~30 nm diameter, produced using e-beam nanolithography and He beam microscope. MEMO will create the first miniaturization roadmap for mechanical machinery down to the atomic scale. This roadmap will be explored node by node along the MEMO project, fabricating, micro-fabricating, and nano-fabricating a planar mechanical calculator down to the atomic scale. The last node of the roadmap, using all the molecular machinery results obtained by the MEMO partners during the project, will lead to the design of a molecular Pascaline. To disseminate the single molecule-mechanics results to industry, MEMO will organize regular Academy-Industry days with high-tech SMEs. General public dissemination will include the organization of the first and second international molecule-car race.

Keywords: nano mechanical technology,molecule machinery,molecule motor,molecule gear,lt uhv,lt uhv 4 stm,afm in solution,nanolithography,organic chemistry,dft calculations
Full scale innovative pressure bulkheads for Regional Aircraft Fuselage barrel on-ground demonstrators (FUSINBUL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Italy
Call: Full scale innovative pressure bulkheads for Regional Aircraft Fuselage barrel on-ground demonstrators (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2022-03-31
Duration (months): 36.0
Total project cost (EUR): 1155971.27
EU funding (EUR): 996481.3800000001
Participants: 5
Project status: CLOSED

Full scale innovative pressure bulkheads for Regional Aircraft Fuselage barrel on-ground demonstrators: The scope of this project is to develop and validate two advanced manufacturing processes to reach a significant reduction in the overall production costs and flows to obtain composite pressure bulkheads for regional aircraft light-weight fuselage manufacturing. A final trade- off analysis will be drawn as well, including costs, advantages, implementation advances, comparison with former costs and frame. In order to achieve the general scope, the consortium members will divide the project in 4 work packages: 1- Production of 2 bulkheads using the 2 different manufacturing techniques (one bulkhead in prepreg and a second one in dry fiber material) and laboratory – NDT testing 2- Production of 4 bulkheads as final demonstrators for fuselage testing, using both manufacturing techniques 3- Trade-off analysis 4- Management of the project The innovative and lighter fuselage concept must be implemented in future aircraft models (among others, Innovative Turboprop, 130 pax, and Advanced Turboprop, 90 pax, are being developed at the moment). The EU policies are clear about the need to reduce 75% the CO2 emissions per passenger-kilometer and 90% of NOX as well. In addition to that, by 2050, aircraft movements must be emission-free when taxiing and air vehicles must be designed and manufactured to be recyclable. Innovative low cost and low weight technologies shall be integrated into the fuselage structural demonstrator to get weight reduction, less manufacturing recurring costs, maintenance improvement and implementation of new eco-compatible materials and processes. And the final step to enter them into use is validation through a test that needs 2 bulkheads as vital elements to close the fuselage cylinder.

Keywords: bulkhead,infusion,full,scale,innovative,barrel,on ground,demonstrators,prepreg,dry fiber,future aircraft,lightweight,reduce emissions