Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the complexity of the reionization history though simulations and multi-wavelength observations (RECAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Italy,Germany,Sweden
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-07-01
End date: 2031-06-30
Duration (months): 72.0
Total project cost (EUR): 9765000.0
EU funding (EUR): 9765000.0
Participants: 3
Project status: SIGNED

The epoch of Reionization marks the last major transition of the Universe: approximately 400.000 year after the Big bang, the neutral intergalactic medium, mainly composed of hydrogen atoms, started to be ionized by high-energy radiation from the first cosmic sources, stars, galaxies. The onset, timeline and topology of the Reionization process are all tightly linked to the nature of the sources of ionizing radiation: by identifying and studying them we can gain fundamental insights into what shaped the evolution of the universe, from the smooth matter distribution of early times, as revealed by the CMB, to the wealth of structures, like galaxies and clusters of galaxies that formed at later epochs. Our project will exploit the critical synergies in expertise of the 4 PIs and their teams, from the modeling of the intergalactic medium ionization and metal enrichment, to detailed observations of the ionizing sources, to shed light on their properties, their environment and the complex energy and baryon exchange between them and the intergalactic medium. We will exploit new extensive datasets coming from state-of-the-art facilities, such as the recently launched JWST, present and future VLT instrumentation and ALMA. To support and drive the interpretation of these new observations, we will develop a novel algorithm to model a self-consistent non-equilibrium 3D multi-frequency radiative transfer through H, He, metals and dust and produce both large scale and zoomed-in simulations that can be readily compared to real data. The proposed research aims at making fundamental steps to decode the mysteries of Cosmic Dawn and solve some of the puzzles in our current theories of early galaxy formation.

Keywords: epoch of reionization intergalactic medium
Local Accessible Urban Digital and Sustainable Factories: New European Bauhaus Approach to Open and Decentralised Urban Manufacturing (LAUDS Factories)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Germany,France,Switzerland,Austria,Portugal,Denmark,Netherlands,Belgium,Spain,Ukraine
Call: Localised and Urban Manufacturing, supporting creativity and the New European Bauhaus (RIA using FSTP) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2830156.25
EU funding (EUR): 2830156.25
Participants: 17
Project status: SIGNED

COVID-19 pandemic manifested the vulnerability of industries, the unpredictability of external shocks and evidenced that traditional solutions do not suffice. Societal transformation and appropriate innovation models along with new technical solutions are seen as important pillars in solving environmental problems. Today, seeds of this societal and industrial transformation exist. Digital communities gather around open-source innovative projects, makers create collectives of professionals, artists and tinkerers in tier-places co-create solutions. SMEs, looking for more sustainable new business models, are inventing circular and sense-making businesses in various territories. User-centric, agile co-creation is a very well known development practice that can be expanded to the whole manufacturing chain. The transition to a low carbon, resource efficient, circular and sustainable bioeconomy, with its technological potentials and proven applications and initiatives like the New European Bauhaus offers solutions to the challenges society is facing today. LAUDS factories is an innovative concept aiming to create small, versatile factories in local and urban areas to co-create and produce customised products in small series. It seeks to incorporate innovative and active resiliency capabilities at production and supply chain levels to support a green, circular, and digital transformation. It can enable artists, creatives, and entrepreneurs to test new ideas and products, and reduce the carbon footprint by cutting transportation costs and time. It also aims to create a more personalised experience for customers, enhance their satisfaction, loyalty, and dynamize the job market. The key exploitable results include a sustainable model for local manufacturing, an updated digital product passport for transparency, and innovation services for makerspaces SMEs and creatives.

Keywords: urban manufacturing,open source hardware,fab labs
Extreme-Aspect-Ratio nanoSystems (EARS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2028-06-30
Duration (months): 72.0
Total project cost (EUR): 2092095.0
EU funding (EUR): 2092095.0
Participants: 1
Project status: SIGNED

Moore’s Law has dominated the trajectory of nanotechnology for the last half century; consistently pushing towards nanocomponents with decreasing size in x, y and z dimensions. It is widely predicted that Moore’s Law will eventually come to an end in 2025 when nanocomponents start to approach the size of individual atoms. Many wonder what kind of nanotechnology can we expect in the “post-Moore” world. Rather than asking how much smaller we can go, EARS will ask how big can we make nano-technology? Imagine we could manufacture extreme-aspect-ratio metamaterials which are only hundreds of atoms thick in z but extend out to meter scales in x and y. Even further, consider covering these meter-sized sheets in nanoscale patterning to give them exceptional material properties not found anywhere in nature or science.. Remarkably, these types of extreme-aspect-ratio metamaterials are increasingly at the heart of many future breakthrough initiatives ranging in functionalities from ultra-fast sails for space-exploration, to sensors that can detect the smallest fundamental forces of physics. EARS will combine my unique expertise in nanofabrication and high-precision optomechanics experiments to realize a cutting-edge platform that opens radical trajectories in unmanned space exploration. My novel approach will allow me to manufacture the highest aspect-ratio metamaterials ever produced and to reliably interface their dynamics with some of the most precise optical controls to date. EARS will herald a new frontier of nanotechnology that has the potential to revolutionize several breakthrough fields of science through metamaterials innovation.

Keywords: space exploration,nanotechnology,nanophotonics,propulsion
Enhanced Solar PV performance through improved research infrastructure for adapted climate conditions (CACTUS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: France,Italy,Spain,Belgium,Chile,Colombia
Call: Strengthen the bilateral cooperation on research infrastructures with Latin America (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 1567655.9
EU funding (EUR): 1495937.15
Participants: 10
Project status: SIGNED

73% of the global CO2 emissions are generated by the energy sector (including transport and buildings). Electrification, combined with power generation using low carbon, renewable energy sources represent a viable path to tackle climate change. In this context, solar power represents today, not only the cheapest energy source, but also the quickest to deploy. Solar power installations, particularly PV have been growing exponentially, a trend which is expected to continue especially considering the fluctuating and volatile gas and oil markets. In an energy system, where solar photovoltaic power will represent the major energy source (potentially up to 69% of the global energy supply by 2050), the need to understand, improve and forecast the operations of PV plants becomes critical for the security and safety of the society. CACTUS proposes to improve the research infrastructure (RI) and its portfolio of services for an enhanced solar PV performance, particularly adapted for various climate conditions (such as tropical, desert, temperate), considering the whole lifetime of PV projects, from design, installation, operations, decommissioning and End of Life. This will be achieved by linking outdoor and indoor measurements with physical parameters based on material analysis, improving algorithms for O&M, developing common data treatment procedures, assessing sustainability related aspects, while enhancing bi-regional scientific cooperation (EU-LATAM) in the renewable energy sector.
REINFORCING THE SCIENTIFIC EXCELLENCE AND INNOVATION CAPACITY IN POLYMER PROCESSING TECHNOLOGIES OF THE FACULTY OF POLYMER TECHNOLOGY (IPPT_TWINN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Slovenia,Austria,Spain,Hungary,Switzerland
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1188125.0
EU funding (EUR): 1188125.0
Participants: 5
Project status: SIGNED

Global annual consumption of plastics is expected to increase from the current 368 million tons (2019) to 1.1 billion tons in 2050. However, this growth also poses some dangers, such as the increasing amount of plastic waste and a rise in CO2 emissions. One of the ways to tackle these problems is to produce more durable products and to use processing technologies that generate less waste. The IPPT_TWINN project addresses both methods, as more durable products can be manufactured through a better understanding of processing methods and waste can be reduced through the application of new technologies and better waste management. The main objective of IPPT_TWINN is to increase the knowledge of polymer processing at FTPO. This will be achieved both through joint scientific work with 4 partners from 4 EU countries, covering several advanced processing techniques and through the organization of a series of events such as workshops, summer schools, expert visits, etc. However, the project is organized in such a way that not only FTPO, but all four partner institutions will make progress in this area. Although partners knowledge largely overlaps, each is a specialist in a particular field, and together they represent a concentration of knowledge in the whole field of modern polymer processing. The proposed joint research work will improve the research excellence and innovation capacity of researchers at FTPO that will result in more scientific publications in high-impact journals. This will make FTPO more attractive as a partner also for other educational and research institutions. Industry representatives will also be invited to the events to be organized, which will increase the visibility of all partners in the business sector and strengthen cooperation. At last but not least, one of the main goals of the project is to train researchers, especially the young ones, how to find suitable calls, right partners and to prepare and manage excellent project proposals.

Keywords: polymer processing,additive manufacturing,polymer characterisation
Increasing metabolic engineering efficiency using a conditionally quiescent fission yeast mutant (QuiescentFactory)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,France
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 3
Project status: SIGNED

The proposed project aims to solve a major challenge in metabolic engineering. In microbial metabolic engineering platforms, consumed nutrients are primarily invested into population growth instead of the production of chemicals of interest. Our team is studying a temperature-sensitive mutant of fission yeast (Schizosaccharomyces pombe), which grows normally at 26°C, but enters quiescence at 36°C, while at the same time maintaining its metabolic activity. Such an engineering platform could represent the holy grail of the metabolic engineering field - a chassis strain that can stop growing but keeps producing metabolites. Application of such pseudo-quiescent strain would be useful to both industrial and academic players. To develop this mutant into a new metabolic engineering chassis, I will first design a molecular cloning toolkit to perform metabolic engineering in S. pombe, which will enable construction and expression of complex biosynthetic pathways. Second, I will characterize the phenotype of the pseudoquiescent S. pombe mutant using a multi-omics approach. I will generate knowledge about mRNA, protein, metabolite and flux dynamics to delineate a genome-scale metabolic model of the chassis under pseudo-quiescence. Then, I will assess the ability of the S. pombe mutant to overproduce 3 different high-value compounds (kavain via phenylalanine, theophylline via purine and artemisinin precursor via mevalonate). Finally, I intend to reproduce the pseudo-quiescent mutant phenotype in other commonly used yeast species (Saccharomyces cerevisiae and Yarrowia lipolytica). In the short term, this research will deliver a new type of a metabolic engineering chassis for the production of complex chemicals to the metabolic engineering community. In the long term, it will contribute to the development of metabolic engineering as a competitive alternative of total synthesis of chemicals, leading to greener and renewable chemical industry.

Keywords: target of rapamycin,schizosaccharomyces pombe,metabolic engineering,heterologous expression,natural products
Bayesian Experimental Design for in situ (Scanning) Transmission Electron Microscopy – BED-TEM (BED-TEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The proposed project, Bayesian Experimental Design for in situ (Scanning) Transmission Electron Microscopy (BED-TEM), addresses challenges in conducting in situ (S)TEM experiments, particularly in selecting optimal stimuli parameters. While recent advancements in microelectromechanical systems (MEMS) have expanded stimulus options, determining appropriate values remains elusive, often relying on time-consuming trial and error. The project aims to introduce a software platform integrating Bayesian experimental design with (S)TEM image analysis, facilitating efficient parameter selection. This platform comprises user interface, image processing, and experimental design modules, offering streamlined workflow and enhanced usability. Leveraging expertise in machine learning and (S)TEM, the project seeks to bridge the gap between complex experimental setups and practical application of Bayesian methods. The envisioned breakthrough lies in transforming offline, iterative parameter determination into an online, iterative process, revolutionizing how in situ experiments are conducted and accelerating materials research and development. The project also poses high risks, particularly in adapting machine learning to (S)TEM data and ensuring market demand for the proposed software. However, mitigation strategies include iterative development, collaboration with experts, and continuous user feedback to align the solution with customer needs and commercial viability. Ultimately, BED-TEM promises to reshape materials science by enabling precise characterization of material behaviors at the nanoscale under real-world conditions, with potential applications spanning electronics, aerospace, and beyond.

Keywords: bayesian,microscopy
BEEware: overcoming risks to bees posed by agrochemical synergies through transcriptomics (BEEware)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Increasing evidence has linked agrochemical exposure to significant declines in pollinator populations, prompting heightened concerns and legislative actions. However, recent studies demonstrate that even legally-applied pesticides continue to adversely affect social bees. A critical challenge in addressing this issue is the co-exposure of pollinators to multiple agrochemicals. In agricultural environments, pollinators are typically exposed to complex mixtures of agrochemicals, rather than the single products upon which risk assessment has been based. This is a problem because recent work has highlighted that agrochemicals often interact synergistically, such that their combined effects are significantly greater than anticipated, and that such synergistic interactions are both larger and more common than expected. Finding a means to identify synergy during the licensing process is difficult because synergistic interactions are hard to predict based on biochemical properties, and because the number of potential mixtures that may be encountered in the real world is too large to allow for untargeted testing of mixtures. I propose a means to overcome this barrier, through transcriptomic profiling of exposure to single products to detect key indicators of synergy for social bees. Gene expression can detect key overriding impacts of individual agrochemicals on bee physiology, and comparison of profiles could potentially predict synergistic partners. Building upon my background in insect transcriptomics and the expertise in agrochemical stress within my proposed research group, I will combine large-scale transcriptomic resources with a comprehensive pre-existing database of synergistic agrochemical pairs to explore the key general shared features of synergistic pairs, such as shared metabolic targets. In doing so, I will identify potential biomarker genes to provide a more sensitive, short-term experimental method for bioassays in pesticide environmental risk assessment.

Keywords: pollinator conservation,anthropogenic stressors,social bees,agrochemicals
The Medieval Book and Networks of Northern Europe c. 1000-1500: Texts, Crafts, Fragments (CODICUM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Norway,Finland,Denmark,Sweden
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 13069110.0
EU funding (EUR): 13069110.0
Participants: 6
Project status: SIGNED

Medieval books were instrumental in shaping European history, communicating rituals, stories and ideas as they were read, copied and shared. To modern scholars they illuminate trade, craft, religious, social and intellectual networks. Less than 10% of the European corpus survives, and in Scandinavia the situation is far worse. However, by historical accident a very high number of Latin fragments – c. 50.000 – from these precious books have been preserved. CODICUM will study and analyse the Nordic book fragments as sources to medieval book culture and its networks. While parchment fragments are found throughout Europe, the numbers and the randomness of their survival in the Nordic countries lend them a special significance. The time is now ripe for interrogating this promising material as one unique European archive by combining approaches from the humanities and the sciences. How was Scandinavia included in different intellectual networks and how did these networks evolve and overlap? How was book production adapted to the limited resources of the north? What can this cross-national archive teach us about curating textual heritage in the long term? CODICUM is led by PIs from four different fields – palaeography, literature, history, and bio-codicology. This unique blending of research expertise enables an innovative synergy which will expand the perspective of European book history c. 1000-1500, reconnect fragments to each other and digitally ‘reassemble’ medieval books, explore the craftsmanship associated with book production, reveal the relationships between the transmitted manuscripts material and illuminate the international networks linking Northern Europe. Researching medieval book culture on an unprecedented scale, CODICUM will seek to resituate our understanding of the book in shaping the Nordic region and connecting the region to the rest of Europe thereby pushing the poorly known Nordic fragment archive into the fore of European book-historical research.

Keywords: parchment,bio codicology,ecclesiastical history,monastic history,crafts,scandinavia