Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LaRge-scalE implementation of COmmunity based mental health care for people with seVere and Enduring mental ill health in EuRopE (RECOVER-E)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Moldova, Republic of,Belgium,Bulgaria,Romania,Croatia,Romania,North Macedonia,France,Netherlands,Netherlands,Montenegro
Call: Global Alliance for Chronic Diseases (GACD) prevention and management of mental disorders (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 3355000.0
EU funding (EUR): 3355000.0
Participants: 16
Project status: CLOSED

For nearly 900 million people living in Europe, mental disorders constitute the most significant yet most neglected public health problem: depression affects an estimated 30.3 million Europeans, snf psychotic disorders 5 million Europeans. People with severe and enduring mental ill health want the same things out of life as other citizens but are often placed in a vulnerable position and are hence afforded less opportunities to attain their goals and thus experience a lower quality of life, and have a lower life expectancy compared to the general population. For many countries that have undergone mental health services reform or have health systems in transition, efforts to make such comprehensive community-based mental health services available resulted in short-lived outcomes or are still to demonstrate substantial impact. RECOVER-E’s aims to ensure well-functioning community mental health teams in 5 countries in Europe (Macedonia, Romania, Bulgaria, Croatia, and Montenegro), which will serve as the central node for coordination and provision of care for people with SMI. Our project narrows the implementation gap by going beyond infrastructure changes and pursuing the development of human resource capacity and care pathways that can be distilled in a comprehensive pathway to scale for regional and national decision-makers for uptake after the project’s life span. RECOVER-E will: 1) Develop evidence based care pathways and treatment protocols for transition to scale for regional and national decision makers in 5 implementation sites; 2) Establish a peer to peer capacity building partnership in community mental health by linking a European expert panel with key stakeholders in 5 implementation sites to co-create community mental health services for people with SMI) 3) Evaluate intervention elements that will enhance sustainable adoption and implementation of community-based mental health care for people with SMI, by carrying out implementation research.

Keywords: community implementation,community engagement,severe mental illness,patient centeredness,implementation science,co creation,iterative learning processes
Error-prone protein synthesis in fungal pathogens Microsporidia: its scope and potential therapeutic targeting (MicroMISTRANS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Microsporidia are ubiquitous and poorly treatable eukaryotic obligate intracellular pathogens that threaten human health and industrMicrosporidia are poorly treatable eukaryotic pathogens that threaten human health and industrially valuable insects, fish, and cattle. Despite Microsporidia being recognized as emerging pathogens that require development of new drugs, many aspects of their biology remain totally unexplored due to a lack of appropriate genetic tools and because only a handful of laboratories in the world can grow and manipulate Microsporidia in infected host organisms or cell cultures. This proposal involves a promising scientist with a background in biochemistry and molecular biology and who will move to a host laboratory in Newcastle University, UK – a renowned center for excellent training of young researchers, and a leading research center in the field of pathogen evolution. The researcher will undertake a multidisciplinary investigation, combining microbiology, proteomics, and molecular biology, in order to investigate how Microsporidia diversify their proteomes through error-prone protein synthesis (mistranslation). The researcher’s training at the host laboratory – in cultivating and manipulating Microsporidia in mammalian cell lines for proteomic and toxicity studies – will synergistically complement the researcher’s expertise in molecular biology of protein synthesis. Completing the project will equip the researcher with a rare, increasingly valuable and transferable skill of Microsporidia experimental biology that will be a key asset in his transition to an independent research career. The project will deliver the first detailed insights into the ability of Microsporidia to produce myriad protein isoforms from their genes as a result of highly inaccurate translation. The outcome of this project will have general implications for understanding how eukaryotic pathogens can modulate their interactions with the host and evade host immune systems.

Keywords: microsporidia,fungal pathogens,intracellular parasites,genetic code mistranslation
Joint Species And Niche Evolution (INSANE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Understanding the tempo and mode of species diversification and concomitant ecological divergence has been a long-sought goal in evolutionary biology. As clades diversify, disparity in niches typically increases when new lineages colonize previously unfilled zones of niche space. Despite its critical importance in understanding life’s evolution, the universality of an interdependence between species diversification and niche evolution, as well as the directionality and drivers of this association, are still poorly understood. This is presumably attributable to the inherent computational and mathematical challenges to develop process-generating models that would couple diversification and niche evolutionary dynamics and the limited availability of extensive and comparable datasets to characterize niches over large radiations integrating neontological and paleontological data. In this project, I will first develop much-needed novel flexible models that allow joint inference on coupled diversification and trait evolution dynamics by allowing joint rate-heterogeneity for radiations of considerable size. Subsequently, I will enhance biological realism by expanding to multivariate evolution of traits, better characterizing the niche concept, and by integrating paleontological data. Finally, I will allow inference on biotic and abiotic drivers of the interrelationship of species and niche diversification. These models will enable examining hitherto untestable classic evolutionary hypotheses in a formal framework on the feedback between diversification and niche evolution, at the intersection of ecology and evolutionary biology. By applying these models to big scale curated datasets of species-level niches and recently available phylogenetic trees for thousands of species and the ability to integrate fossil information, I will substantially increase our understanding on how biodiversity, both in terms of richness and niches, is generated.

Keywords: evolutionary biology,diversification,phylogenetic comparative methods,bayesian statistics
Numii: A real-time and non-invasive monitoring tool for the prevention of work-related musculoskeletal disorders (Numii)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the EU during the past decades life expectancy and the proportion of people aged ≥65 have increased; consequently, all countries have shifted their policies towards prolonging the working life. However, this has not been matched by measures supporting longer and healthier working lives. In 2013, the % of European workers who self-reported work-related health problems during the previous year amounted to 7.9%,equal to a total of ~19.6 million people and nearly 2 every 3 people having issues and being absent from work for at least 4 days therefore. Besides the obvious negative effects on the persons’ wellbeing, sick leave also has an economic impact: the annual costs for employers are estimated at €47 billion on average and the national cost is about 2.5% of GDP. Among those with work-related health problems, 60% had musculo-skeletal disorders, with the highest rate (11%) observed in people aged 55-64. Present methods to determine which movements and postures are dangerous for the workers’ health are incomplete and imprecise, so it’s difficult to improve the working conditions to protect and preserve workers’ health. This is particularly true for operators working in assembly lines in the industry sector, where there are uncomfortable positions and repetitive tasks. AIO created Numii to let employers understand precisely which movements can be dangerous for each worker’s health, in order to improve their working conditions and preserve their wellbeing. Thanks to one acquisition sensor and processing module based on AI and a tablet, the product collects and monitors in real-time the operator’s biomechanical movements in daily working conditions. With these data it’s possible to identify dangerous or risky movements and postures that would lead to a health issue if not treated appropriately. AIO will also collect a large amount of data about the human body at work, which will allow policy makers to develop new strategies to support a longer & healthier working life.

Keywords: work related health problems,working life,working conditions,work monitoring
Growth and Diversification in the Presence of Industry Linkages (INDLINK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Türkiye
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

This project investigates the growth and diversification patterns of countries in the presence of industry linkages in four separate but complementary objectives. In the fırst objective, the consequences of the linkages will be captured through the observed pattern of industries throughout countries and an economic micro-foundation will be provided using trade models. In the second objective, the diversification pattern and speed of countries will be related to the country level and product level quality measures. In the third one, temporal aspect of the trade data will be used and the effects of the spillovers will be analyzed using vector autoregressive models. Finally, in the fourth objective, effects of one specific type of spillover, namely the Input-Output linkages, will be explored both theoretically and empirically. The Experienced Researcher intends to build a successful academic career and impacting the decisions of policymakers within Turkey and Europe. This fellowship will enable Dr. Yildirim to embark on such a journey in a suitable environment provided by Koç University. The fellowship will complement Dr. Yildirim’s interdisciplinary background and he will also have the opportunity to establish himself in the field of economics.

Keywords: complex systems,networks
“Multi-component nanoparticles as bimodal contrast agents for MRI and optical detection of tumors and for targeted photodynamic therapy” (MCNANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

The main aim of this proposal is to synthesize a range of lanthanide containing nanoparticles with an upconverting core, that can be excited in the infrared region to yield emission in the visible range, as for MRI and optical imaging. The nanoparticles will be covered with a rare earth doped MRI active shell and decorated with targeting moieties, which offers a means of targeting cancer cells that greatly over express the receptors. Further we will develop “phototheranostic” agents by anchoring the photo active anti cancer drug in between the receptors and the surface of upconverting/MRI active nanoparticle. A platform for synthesis of water soluble, modular target specific bimodal agents based on nanoprobes will be developed that will exhibit efficient upconverted photoluminescence from the rare-earth ions (Er3+/Tm3+) doped into fluoride nanomatrix. Simultaneously, the Tb3+/Dy3+/Ho3+ present at the shell will make them suitable as T2 contrast agents for MRI. Specific tumor targeting strategies will be developed by attaching targeting components like folic acid, cholesterol or cyclic-RGD to the surface of the nanoparticles. Functionalization of nanoparticles with [Pt(N3)2(OH)2(NH2-R)(py)] drug, which can be photoactivated by the blue light emitted from the nanoparticle core upon excitation at 980, will result in a novel phototheranostic anti-cancer agent. This system may allow a large degree of control of the therapeutic efficacy and ultimately lead to simultaneous diagnosis and treatment in clinical applications. The unique multidisciplinary approach adopted here which combines areas of nano-chemistry, spectroscopy and bio-imaging, is expected to lead to a disruptive change in the area of cancer research. The combination of these areas would allow for the first time the development of biocompatible “phototheranostic” agents for the simultaneous detection by MRI/optical imaging and cure of the cancer- affected tissues.

Keywords: bimodal contrast agents,active core,active shell ac,as nanoparticles,lanthanide luminescence,upconversion,magnetic resonance imaging mri,phototheranostic anticancer agent
TRA VISIONS 2018 (TRA VISIONS 2018)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Italy,Austria,Germany,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Innovation awards for students and researchers in the context of the Transport Research Arena conference - TRA 2018 (H2020-MG-2016-SingleStage-RTD-MOVE, 2016)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 599937.5
EU funding (EUR): 599937.5
Participants: 9
Project status: CLOSED

The concept of this project is to organise two competitions for transport research awards to be announced at the TRA conference in 2018 - A Young researchers' competition with the goal of stimulating the interest among young researchers/students in the field of sustainable surface transport. - A competition for senior researchers in the field of innovative surface transport concepts based on results only from EU-funded projects.

Keywords: student competition,researcher competition
The world’s largest secure collaboration suite (ProtonSuite)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Switzerland
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays, individuals and businesses are more concerned about privacy and security than in the past and demand more secure and reliable products and services. Moreover, on May 25 2018, a new European privacy regulation, the General Data Protection Regulation (GDPR), will come into effect. This regulation will be implemented in all local privacy laws across the entire EU region and it will apply to all companies selling to and storing personal information about citizens in Europe. To achieve GDPR compliance, organisations will have to secure all communication channels (email, chat, data sharing) with customers, for which end-to-end encryption will play a key role. In such a scenario, companies have no choice than quickly adapt their data protection procedures and acquire technology that complies with the new regulation. ProtonSuite will is the first cloud-based cybersecure collaboration platform that provides users with end-to-end secure communication channels and collaboration tools. The platform is built following the essence of privacy by design, which means that privacy is taken into account from the inception of the product concept. Furthermore, the solution goes even further and tackles the biggest problem that is preventing the encryption to reach the mass audience: key distribution and key authentication. Our aim is to bring to the market ProtonSuite in 2020 with a clear vision in mind: democratize data privacy and security. Our commercial success will be based on our ability to up-sale the product to our existing customer base, attract new customers and foster our collaboration with open source community (GitHub, OpenPGP) and universities (EPFL, MIT), which are acting as our prominent evangelists. After the completion of the project, with the product commercialization we will achieve a forecasted cumulative revenue of € 98 Million. Considering the funding for phase 2 (1.8M €), we forecast a R.O.I of 6.9 (2020-2024) while payback will be reached in 2021.

Keywords: cybersecurity,encryption,public directory,privacy,mail,drive,collaboration suite
Integration of Innovative Ice Protection Systems (I3PS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Spain,Belgium,Belgium,United Kingdom
Call: Integration of innovative ice protection systems into structure and their validation (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-12-31
Duration (months): 34.0
Total project cost (EUR): 1350090.0
EU funding (EUR): 1349900.0
Participants: 5
Project status: CLOSED

This proposal fits within the framework of aircraft effectiveness constant improvement by reducing fuel and power consumptions. Its ultimate goal is to economically remove ice accreting on aircraft structure critical parts and thus increase reliability and mass saving on the global function. By comparison with the present existing solutions which are based on active pneumatic and electro-thermal means the targeted solutions will enable electrical power consumption, cost and mass reductions and ease the overall integration process. The subject of this proposal is to integrate and test two innovative ice protection systems in aircraft structures. The first system is based on two-phase heat transport and will be tested in a turboprop metallic air intake. The second system is based on electromagnetic induction and will be tested on a wing fixed leading edge and on a flap leading edge.

Keywords: ice protection,testing,icing wind tunnel,two phase heat transport,electromagnetic induction
Most Easy, Efficient and Low Cost Geothermal Systems for Retrofitting Civil and Historical Buildings (GEO4CIVHIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Spain,Germany,Spain,Ireland,Italy,Italy,Malta,Romania,Switzerland,Belgium,Greece,Belgium,France
Call: Easier to install and more efficient geothermal systems for retrofitting buildings (H2020-LCE-2017-RES-IA, 2017)
Start date: 2018-04-01
End date: 2023-11-30
Duration (months): 68.0
Total project cost (EUR): 8143120.97
EU funding (EUR): 6841960.75
Participants: 20
Project status: SIGNED

The solutions to apply the shallow geothermy will be different in function of the building type, the climate and the geological conditions of the underground, the geothermal system (drilling methodology, GSHE, grouting,..). The main objectives will be : - identify and where missing develop building blocks solutions in drilling (machines and methods), GSHE types, heat pumps and other renewable energy/storage technologies, heating and cooling terminals with the focus on every type of built environment, civil and historical; - generate and demonstrate the most easy to install and cost-effective geothermal energy solutions using and improving existing and new tools. In the area of shallow geothermy of further innovations are needed to provide a pan – European solution base for all the parameter combinations. More efficient borehole heat exchangers and lower cost drilling methodologies/machines adapted to the built environment will be realised as improvement or innovation related to the previous projects. This approach will bring to a easy applicability in the building refurbishment presenting different constrains, to reduce the overall drilling cost in the given geological conditions, will to avoid replacement of heating terminals constructing modular high temperature heat pumps and hence to reduce the deep retrofit costs. The association with tools (DSS, APPs, etc.) will enable to find the best solution for each combination of building type/climate/geology y. Moreover, the design tools will reduce overall engineering costs, avoid design mistakes and form the basis for a major dissemination effort. Application tools will help the users for different practical aspects. Finally to help knowledge dissemination and formations of the future experts a pan – European network of centres of excellence based on past expertise but complemented with the new developments should become instrumental in breaking down the barriers in shallow geothermal energy in building renovation.

Keywords: shallow geothermal,ground source heat exchanger,drilling machines,historical buildings