Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Europe Africa Marine Network (EAMNET)

Framework: FP7 — Cooperation
Programme: Space
Destination: Cross-cutting activities
Action type: Coordination and support actions
Countries involved: United Kingdom,South Africa,Portugal,Denmark,Germany,United Kingdom,Tanzania, United Republic of,Ghana,France,Egypt
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-03-01
End date: 2013-06-30
Duration (months): 40.0
Total project cost (EUR): 1360799.48
EU funding (EUR): 997067.3
Participants: 10
Project status: CLOSED

EAMNet aims to construct a network linking Earth Observation (EO) information providers, user networks and centres of excellence in Europe and Africa in the area of coastal and marine observations towards sustainable development in Africa. The network will undertake capacity building and maintenance and build upon existing infrastructure and expertise in Africa. The overall aim is to improve the exploitation of EO data for coastal and oceanic monitoring towards an Africa-wide observation system (GOOS-Africa). It will provide an interface between European GMES-related core and downstream services and R&amp;D projects (notably MyOcean) and African initiatives (e.g. AMESD) with the emerging GMES-Africa initiative. It will also provide further links with GEO. Specifically, EAMNet will: •Promote exploitation of existing and new marine EO data streams produced in Europe and Africa (e.g. MyOcean, OSI-SAF and DevCoCast) and disseminate the data using fast and reliable systems (GEONETCast) • Harmonize and contribute to the evolution and improvement of application of these data • Improve the coverage of the marine GEONETCast reception network • Contribute to existing training courses undertaken in AMESD, DevCoCast and other initiatives • Develop EO specific modules within the courses of three African Universities • Coordinate R&amp;D activities in Africa with GMES projects in Europe and promote best-practice through targeted exchange of personnel and open fellowships • Connect the African and EU marine communities by co-organizing yearly symposia (in parallel with the alternating AARSE and AMESD meetings), maintaining a web site and publishing a regular newsletter • Identify the requirements of the African stakeholders for the provision of GMES services • Contribute to the implementation of the Action Plan for GMES and Africa Partnership resulting from the Lisbon Process on “GMES and Africa” and planned to be endorsed at the next EU-Africa Summit.

Keywords: capacity building,geonetcast,goos africa,eo data,training,eu africa action plan
Drugs and Precursor Sensing by Complementing Low Cost Multiple Techniques (CUSTOM)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Collaborative project
Countries involved: Italy,Finland,France,France,Spain
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-06-01
End date: 2013-11-30
Duration (months): 42.0
Total project cost (EUR): 5295523.0
EU funding (EUR): 3486406.0
Participants: 11
Project status: CLOSED

A large number of techniques have been developed in the latest decades, which are able to screen and identify specific molecules for drug precursors detection even at very low concentration in lab testing.Nevertheless the objective to build up a system which proves to be easy to use, compact, able to provide screening over a large number of compounds and discriminate them with low false alarm (FA) and high probability of detection (POD) is still an open issue.The project will focus on employing multiple techniques, integrating them in a complex system which employs them in a complimentary approach in order to identify an optimum trade-off between opposite requirements: compactness, simplicity, low cost vs. sensitivity low false alarm rate, selectivity. Known techniques, as fluorescence will be improved by mean of novel proteins, as antibodies to extend Probability of Detection (PoD). The techniques are: 1. A low cost, high data throughput sensing technique, based on UV-Vis-NIR fluorescence. Fluorescence will be enhanced by development of Organic macro-molecules sensitive to specific classes of compounds of interest (ephedrine, pseudoephedryne, P2P, …) in the domain of drug detection. The fluorescence analysis will be based on an ‘opto-chip’ which can incorporate an array of different properly engineered fluorescent chemical protein able to bind to the analytes with an ‘immuno-type’ reaction. An array of classes of compounds can be thus very fast discriminated by one-shot measurement. 2. A high sensitivity and selectivity, but compact and low weight, spectroscopic sensing technique in MIR–IR optical range, based on Laser PhotoAcoustic Sensor (LPAS). Detection of drug precursors based on spectroscopic techniques can guarantee a good selectivity, a low Probability of False Alarm and a suitable operation speed. The size of the photo-acoustic cell can be made as small as possible for a compact sensor and, depending on the performances, it can cost down to 1000€.

Keywords: drug precursors detection,ephedrine,pseudoephedryne,p2p,false alarm (fa),probability of detection (pod),uv-vis-nir fluorescence,binding organic molecules,opto-chip,lpas,algorithms,database
Integration of Security Technology Supply Chains and Identification of weaknesses and untapped potential (SECURECHAINS)

Framework: FP7 — Cooperation
Programme: Security
Destination: Security Research coordination and structuring
Action type: Coordination and support actions
Countries involved: Germany,Italy,Spain,Romania,France,Portugal,Germany,United Kingdom,Germany,Belgium,Greece
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 1082006.63
EU funding (EUR): 820032.0
Participants: 11
Project status: CLOSED

Security is one of the highest goods of mankind for which it is worth to make available the most advanced technologies in order to protect it. This achievement is a great challenge, realizing diversity of technologies applied for security and the tremendous resources to provide it all over Europe. The Security sector is widely recognised as a key asset for the future of Europe and World. Security is a concern for everyone. New ideas and developments are needed to improve the research capabilities of the actors involved and to improve the security of European citizens in general. However, Security is also by common standards a very unusual business requiring specific rules, namely: it works on very long lead times, requires huge capital sums for developing its products and research and also requires a strong relation between all the organisations involved in the area. Europe needs to invest in Security targeting at the Industrial and research communities in order to address today’s and future challenges in this specific Sector, especially with respect to society and its political, demographic, social and economical evolutions. Therefore, it’s essential to build and maintain a highly competitive environment and this is only possible if the full integration of business processes across enterprises (involving key suppliers, usually SME) throughout the entire supply chain is achieved. In order to accomplish this to the maximum extent, the SecureCHAINS project will take the necessary steps to review the present status, scrutinize available resources and initiate a dialogue with the stakeholders and integrators of the security “big projects”. With this project we will have a clear picture of the technological capabilities in Europe regarding in particular the SME potentials to deliver the most advanced technologies to the integrated projects.

Keywords: integration sme sompetitiviness europeanizarion security supply chains
Monitoring and Assessing Regional Climate change in High latitudes and the Arctic (MONARCH-A)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space-based applications at the service of the European Society
Action type: Collaborative project
Countries involved: United Kingdom,Germany,France,Russian Federation,Norway,Denmark,France
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-03-01
End date: 2013-05-31
Duration (months): 39.0
Total project cost (EUR): 3942504.0
EU funding (EUR): 2884484.0
Participants: 8
Project status: CLOSED

By adopting an Earth system approach the ultimate goal of MONARCH-A is to generate a dedicated information package tailored to a subset of multidisciplinary Essential Climate Variables and their mutual forcing and feedback mechanisms associated with changes in terrestrial carbon and water fluxes, sea level and ocean circulation and the marine carbon cycle in the high latitude and Arctic regions. The dedicated information package will be based on the generation of time series of 11 multidisciplinary ECVs including land cover, permafrost, river discharge, snow cover, ice sheet elevation, sea ice drift and volume, sea level, ocean currents and transport of heat and freshwater, ocean color, near surface wind field and CO2 partial pressure. Land cover and fire will use existing sources of data, with particular focus on consistencies between data sources and conversion to forms in which these ECVs can be ingested into the models. Sea ice extent and concentration, sea ice thickness, sea surface temperature, and sea level bounded by +/- 65 degrees latitude will be pulled from existing archives and data bases to complement these ECVs. Through reanalyses adequate and consistent description of the status and evolution of the high latitude and Arctic region will be provided in the context of terrestrial carbon and water fluxes, sea level and ocean circulation and marine carbon cycle. It will focus on changes during the last 30 - 50 years. This will ensure new scientific input for the elaboration and implementation of European and international policies and strategies on the environment and society, including climate adaptation strategies addressing European, national, regional and local levels.

Keywords: high latitude,arctic,multidisciplinary,sea level,ocean carbon cycle,terrestrial carbon sources/sinks,synthesis
Conditions for Space Policy and related Action Plan Consolidation in Europe (C-SPACE)

Framework: FP7 — Cooperation
Programme: Space
Destination: Cross-cutting activities
Action type: Coordination and support actions
Countries involved: France,Sweden,Italy,Romania,United Kingdom
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-03-01
End date: 2011-09-30
Duration (months): 19.0
Total project cost (EUR): 794949.4
EU funding (EUR): 674995.0
Participants: 6
Project status: CLOSED

In Europe there is a growing interest to reinforce space policy. While the financial crisis is threatening the development of European economies, a stronger European Union is needed to maintain strategic public policies and to supply MS defaulting capabilities. Space Policy is clearly on the top of such an agenda because it involves a multi-layer constituency. Space Policy presents a unique political value. It is also clear that some of the new priorities within the European Space Policy, such as the contribution of Space to the climate change or the exploration of space will take place in a global endeavour and will imply the need for Europe to develop a long-term planning in the context of an enhanced dialog with international partners. The development and implementation of a European Space Policy can be strengthened through a multi level policy study. The objectives of this study will be to define a comprehensive approach towards milestones for Space in Europe. A double framework will be adopted: _analysis of the drivers for change about space in Europe (multi level policies studies), meaning a deepening of scenarios for space key sectors. _building up a comprehensive Space policy vision. Based on a comprehensive analysis of ongoing space trends in Europe (Drivers) the study will propose a high level set of concepts to be developed within ongoing European integration, and able to foster a growing identity for space in Europe. The proposed study will follow a 3-step logic leading to findings and recommendations for possible milestones for the European in the next years : - Assessment of current orientations and possible horizons for European Space policy - Assessment of resources and opportunities to be used for implementing the European Space Policy - Concluding part: Ways forward for the European Space policy

Keywords: european space policy,space science,space exploration,esdp and space
Switch recombination: a model system for DNA editing and repair in human lymphocytes with relevance for primary immunodeficiency and cancer formation (IMMUNOSWITCH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Sweden
Call:  (ERC-2009-StG, 2009)
Start date: 2009-12-01
End date: 2014-11-30
Duration (months): 60.0
Total project cost (EUR): 1888166.0
EU funding (EUR): 1888166.0
Participants: 1
Project status: CLOSED

The aim of this project is to try to understand the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM). We have developed a series of PCR-based assays to study in vivo generated CSR junctions and the pattern of mutations introduced in the immunoglobulin variable region genes in human B cells, allowing us to characterize CSR and SHM in patients with immunodeficiency due to defect(s) in DNA repair/recombination. Novel in vitro CSR assays, based on GFP expression, allowing quantitative measurement of substrate recombination, are also being developed. In addition, we have initiated an evolutionary analysis of the function and structure of activation-induced deaminase, an essential molecule involved both in CSR and SHM, aiming to identify CSR specific-cofactor(s). Combining these approaches, we will be able to define the DNA repair pathways involved in CSR and SHM. The suggested project requires access to patients with various defects in the DNA repair pathways. Many of these diseases are exceedingly rare. However, through worldwide collaboration, we have obtained samples from a majority of the diagnosed patients. We are also refining the existing screening methods and developing novel methods, that will allow identification of additional patients both with recognized and new diseases caused by mutations in DNA repair pathways. Finally, we hope to be able to address the question whether illegitimate CSR events are associated with predisposition to lymphomagenesis in patients with immunodeficiency/DNA repair defect(s), by analyzing the CSR induced chromosomal breaks and translocations in these patients. A large-scale sequencing project is also planned to characterize the CSRnome in B-cell lymphoma samples.

Keywords: class switch recombination,somatic hypermutation,immunoglobulin,dna repair,primary immunodeficiency,lymphoma,lymphomagenesis
RNAi-mediated viral immunity in insects (ANTIVIRALRNAI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2009-StG, 2009)
Start date: 2009-10-01
End date: 2014-12-31
Duration (months): 63.0
Total project cost (EUR): 1900000.0
EU funding (EUR): 1900000.0
Participants: 1
Project status: CLOSED

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). One of the functions of this pathway is the defense against parasitic nucleic acids: transposons and viruses. Previous results demonstrated that viral infections in Drosophila melanogaster are fought by an antiviral RNAi response and that components of the endocytic pathway are required for dsRNA entry to initiate the RNAi response. Recently we have shown that infected insect cells spread a systemic silencing signal that elicits a protective RNAi-dependent immunity throughout the organism. This suggests that the cell-autonomous RNAi response is insufficient to control a viral infection and that flies also rely on systemic immune response to fight against such infections. As a junior group leader, I will study the mechanisms that mediate the RNAi-based antiviral response in insects. By combining biochemical, cellular, molecular and genomic approaches, both in vivo and in cell culture, I will analyze the mechanisms underlying viral tropism, systemic propagation of the antiviral signal and the basis of the persistence of the antiviral state. Furthermore, I will examine whether the dsRNA-uptake pathway is conserved in mosquitoes and its relationship with viral immunity in that host. This comprehensive approach will tackle how this nucleic acid-based immunity works in insects to generate an anti-viral stage. A better understanding of the role of RNA silencing in insects during virus infection will allow the exploitation of this pathway for improvement of public health related problems such as arbovirus infection and disease.

Keywords: rna silencing,small rnas,antiviral mechanism
Hyperpolarized Biosensors in Molecular Imaging (BIOSENSORIMAGING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Germany
Call:  (ERC-2009-StG, 2009)
Start date: 2009-12-01
End date: 2014-11-30
Duration (months): 60.0
Total project cost (EUR): 1848600.0
EU funding (EUR): 1848600.0
Participants: 1
Project status: CLOSED

Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made available for biomedical applications. The advancement focuses on high-sensitivity in vitro diagnostics for localization of tumour cells in cell cultures and first demonstrations on animal models based on a transferrin-functionalized biosensor. Such a sensor will enable detection of subcutaneous tumours at high sensitivity without any background signal. More detailed work on the different available Hyper-CEST contrast parameters focuses on an absolute quantification of new molecular markers that will improve non-invasive tumour diagnostics significantly. NMR detection of functionalized Xe biosensors have the potential to close the sensitivity gap between modalities of nuclear medicine like PET/SPECT and MRI without using ionizing radiation or making compromises in penetration depth like in optical methods.

Keywords: magnetic resonance imaging,hyperpolarized xenon,biosensors
Small non-coding RNAs in cell function and disease (SRNAS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2009-StG, 2009)
Start date: 2010-01-01
End date: 2014-12-31
Duration (months): 60.0
Total project cost (EUR): 1139998.0
EU funding (EUR): 1139998.0
Participants: 1
Project status: CLOSED

Small non-coding RNAs including microRNAs (miRNAs), short interfering RNAs (siRNAs) or Piwi interacting RNAs (piRNAs) have been discovered recently and extensive research revealed that such RNAs function as key-regulators of gene expression. Small non-coding RNAs cooperate with members of the Argonaute (Ago) protein family to regulate gene expression at the level of transcription, mRNA stability or translation. While small RNAs serve as sequence-specific guides, Ago proteins constitute the mediators of gene silencing processes. In order to identify functional classes of small non-coding RNAs, it is important to analyze interactions with members of the Ago protein family. We propose to isolate and clone Ago-associated small RNAs. Processing products of small nucleolar RNAs (snoRNAs) can give rise to functional small RNAs and it is very likely that other non-coding RNAs including tRNAs or rRNAs produce functional small RNAs with so far unrecognized cellular functions. In the second part of the proposal we plan to investigate the role of miRNAs in disease. In the cancer field, the cancer stem cell hypothesis suggests the existence of tumor stem cells that are important for tumor maintenance. Such stem cells are difficult to target and might be the cause of tumor re-appearance after therapy. Since glioblastoma is a fatal tumor and tumor stem cells can be isolated we will analyze miRNA expression in glioblastoma stem cells. Indeed, a first cloning approach identified several tumor stem cell specific miRNAs. In the proposed project we plan to analyze the biological function of such glioblastoma stem cell-specific miRNAs. We hope that our work not only contributes to a better understanding of the cancer stem cell hypothesis but will also depict new ways for cancer therapy.

Keywords: cancer stem cells,small regulatory rnas,gene silencing
Deciphering mechanisms of ciliary disease (CILIARYDISEASE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Germany
Call:  (ERC-2009-StG, 2009)
Start date: 2010-02-01
End date: 2015-01-31
Duration (months): 60.0
Total project cost (EUR): 1449640.0
EU funding (EUR): 1449640.0
Participants: 1
Project status: CLOSED

Ciliopathies are pleiotropic diseases with a wide spectrum of human phenotypes. These include cyst formation in the liver and pancreas, respiratory disorders and a predisposition to diabetes and cancer. The pleiotropic nature of these disorders may reflect the many roles cilia play in physiology and signalling, highlighting the clinical importance of understanding their function in organ development and homeostasis. Despite the biological importance of cilia and decades of research, many aspects of cilia assembly and disassembly remain elusive. The earliest steps of cilia assembly involve conversion of the centrosome into a basal body, which anchors the cilia to the plasma membrane. Odf2 is one of the only proteins known to be important for this process, thus Ofd2 mutant cells lack cilia. During cell cycle re-entry primary cilia disassemble, the basal body dislodges from the plasma membrane and duplicates to serve as the mitotic centrosome. We recently identified Pitchfork, which functions in basal body-to-centrosome conversion and regulates embryonic patterning. The overall aim of this proposal is to better understand the cellular and bio-molecular mechanisms underlying ciliary disease. We will conditionally delete Odf2 and Pitchfork during embryogenesis and organogenesis. This will reveal the different requirements for the process of cilia assembly and disassembly in embryonic development, organ formation and homeostasis. The phenotypes will be analyzed at all levels of complexity. Subcellular imaging and identification of protein interaction partners will uncover the molecular basis of cilia assembly and disassembly. In summary, this project will decipher mechanisms underlying a wide spectrum of human ciliary disease and will open new avenues of clinical research.

Keywords: cilia assembly and disassembly,organ development and disease,cellular and molecular mechanisms