Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
QROWD - Because Big Data Integration is Humanly Possible (QROWD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Big Data PPP (cPPP)
Countries involved: Italy,Germany,Germany,Spain,Poland,Switzerland,United Kingdom
Call: Big Data PPP: cross-sectorial and cross-lingual data integration and experimentation (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 3993505.0
EU funding (EUR): 2969367.5
Participants: 11
Project status: CLOSED

Big Data integration in European cities is of utmost importance for municipalities and companies to offer effective information services, enable efficient data-driven transportation and mobility, reduce CO2 emissions, assess the efficiency of infrastructure, as well as enhance the quality of life of citizens. At present this integration is substantially limited due to the following factors: 1) Urban Big Data is locked in isolated industrial and public sectors, and 2) The actual Big Data integration is an extremely hard technical problem due to the heterogeneity of data sources, variety of formats, sizes, quality as well as update rates, such that the integration requires significant human intervention. QROWD addresses these challenges by offering methods to perform cross-sectoral streaming Big Data integration including geographic, transport, meteorological, cross domain and news data, while capitalizing on human feedback channels. The main objectives of QROWD are: (1) Facilitating cross-sectoral Big Data stream integration for urban mobility including real-time data on individual and public transportation combined with further available sources, such as weather conditions and infrastructure information to create a comprehensive overview of the city traffic; (2) Supporting participation and feedback of various stakeholder groups to foster data-driven innovation in cities; and (3) Building a platform providing hybrid computational methods relying on efficient algorithms complemented with human computation and feedback. The main outcomes of QROWD are: (1) Two data value chains in the sectors of urban mobility and public transportation using a mix of large scale heterogeneous multilingual datasets; and (2) Cross-sectoral and cross-lingual technology, including algorithms and tools covering all phases of the cross-sectoral Big Data Value Chain building on W3C standards and capitalizing on a flexible and efficient combination of human and machine-based computation.
Crop resistance improvement by mining natural and induced variation in host accessibility factors (ACHILLES-HEEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1991054.0
EU funding (EUR): 1991054.0
Participants: 1
Project status: CLOSED

Increasing crop yield to feed the world is a grand challenge of the 21st century but it is hampered by diseases caused by filamentous plant pathogens. The arms race between pathogen and plant demands constant adjustment of crop germplasm to tackle emerging pathogen races with new virulence features. To date, most crop disease resistance has relied on specific resistance genes that are effective only against a subset of races. We cannot solely rely on classical resistance genes to keep ahead of the pathogens. There is an urgent need to develop approaches based on knowledge of the pathogen’s Achilles heel: core plant processes that are required for pathogen colonization. Our hypothesis is that disease resistance based on manipulation of host accessibility processes has a higher probability for durability, and is best identified using a broad host-range pathogen. I will employ the filamentous pathogen Phytophthora palmivora to mine plant alleles and unravel host processes providing microbial access in roots and leaves of monocot and dicot plants. In Aim 1 I will utilize plant symbiosis mutants and allelic variation to elucidate general mechanisms of colonization by filamentous microbes. Importantly, allelic variation will be studied in economically relevant barley and wheat to allow immediate translation into breeding programs. In Aim 2 I will perform a comparative study of microbial colonization in monocot and dicot roots and leaves. Transcriptional profiling of pathogen and plant will highlight common and contrasting principles and illustrate the impact of differential plant anatomies. We will challenge our findings by testing beneficial fungi to assess commonalities and differences between mutualist and pathogen colonization. We will use genetics, cell biology and genomics to find suitable resistance alleles highly relevant to crop production and global food security. At the completion of the project, I expect to have a set of genes for resistance breeding.

Keywords: non nb lrr resistance,allelic variation,plant pathogen interaction,broad host range pathogen,phytophthora,organ specific mechanisms,crop plants,barley,wheat,medicago truncatula
Sensing activity-induced cell swellings and ensuing neurotransmitter releases for in-vivo functional imaging sans hemodynamics (DIRECT-fMRI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1787500.0
EU funding (EUR): 1787500.0
Participants: 1
Project status: CLOSED

Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag ‘active’ brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known. We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-MRI is an exquisite microstructural probe, sensing cell sizes (l) with an unprecedented l^6 sensitivity (compared to l^2 in conventional approaches); RE MRS is a new spectral technique capable of recording metabolic signals with extraordinary fidelity at ultrahigh fields. This proposal aims to harness these novel concepts for mapping neural activity directly, without relying on hemodynamics. The specific objectives of this proposal are: (1) Mapping neural activity via sensing cell swellings upon activity (μfMRI): we hypothesize that NOGSE can robustly sense subtle changes in cellular microstructure upon neural firings and hence convey neural activity directly. (2) Probing the nature of elicited activity via detection of neurotransmitter release: we posit that RE MRS is sufficiently sensitive to robustly detect changes in Glutamate and GABA signals upon activation. (3) Network mapping in optogenetically-stimulated, behaving mice: we propose to couple our novel approaches with optogenetics to resolve neural correlates of behavior in awake, behaving mice. Simulations for μfMRI predict >4% signal changes upon subtle cell swellings; further, our in vivo RE MRS experiments have detected metabolites with SNR>50 in only 6 seconds. Hence, these two complementary –and importantly, hemodynamics-independent– approaches will represent a true paradigm shift: from indirect detection of neurovasculature couplings towards direct and noninvasive mapping of neural activity in vivo.

Keywords: magnetic resonance,ultrahigh magnetic fields,neurotransmitters,magnetic resonance spectroscopy,animal behavior,diffusion,porous media,functional mri,fmri
Men, Women and Care: The gendering of formal and informal care-giving in interwar Britain (MenWomenCare)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1079426.0
EU funding (EUR): 1079426.0
Participants: 1
Project status: CLOSED

One of the most profound and long-lasting effects of the war efforts of all major combatant nations during the First World War was the high number of casualties caused by modern industrial warfare. Examining the case of Britain, this project asks what formal and informal structures developed in the interwar years to provide medical and social care to the unprecedented number of war disabled. It further explores how these different forms of care both were shaped by gendered understandings of care-giving and utilized gender to mobilize public and private support for disabled ex-servicemen. While there have been a number of studies of charitable organizations established for the care of disabled ex-servicemen, and of the relationships between the State, the soldier and his family in this era, this is the first study to examine the role of these formal institutions alongside and in relation to the informal social and medical care provided by the family in this period. Through its examination of issues of social, political and domestic responsibility for the care of disabled ex-servicemen, issues which continue to have relevance in light of the survival of service personnel from conflicts such as Iraq and Afghanistan who have suffered massive injuries and multiple amputations, the project seeks not only to engage with historical discussions of the development of medical practice in the first half of the twentieth century but also, through engagement with current policy makers working with and for disabled service personnel, to make a significant intervention into contemporary social policy relating to the provision of medical and social care. By utilizing the methodological prism of gender studies, this project also explores the ways in which medical and social care were gendered to interrogate social and cultural understandings of care-giving in the first half of the 20th century and thereby gain greater insight into the relationships between men, women and care.

Keywords: history of masculinity,history of disability,first world war,history of medicine,history of the family,history of welfare,personal narrative,care giving,social care,social policy
A Novel Detection protocols for REliable prostate cancer Assays (Andrea)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Slovakia
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-08-31
Duration (months): 21.0
Total project cost (EUR): 149499.93
EU funding (EUR): 87500.0
Participants: 2
Project status: CLOSED

The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercialisation of the PCa diagnostics kit. Pre-clinical (60 human serum samples) is ongoing and retrospective validation study (450 human serum samples) of the assay will be performed by statistical analysis using a receiver operating characteristic (ROC) curve. The PoC describes all steps, which have been developed so far and all necessary steps, which need to be done for retrospective validation study, product development and commercialisation through our newly incorporated start-up Glycanostics Ltd. (www.glycanostics.com). We will provide PCa diagnostic test resulting in a second opinion to guide the right decision if the biopsy is needed. This will avoid the needless and unreliable biopsies and in the future rival an inaccurate PSA testing.

Keywords: prostate cancer,diagnostics,biomarkers,glycans,lectins,assay kit
Development of a tool kit to investigate protein ubiquitylation in biomedical research (UBIQUITON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-03-01
End date: 2019-10-31
Duration (months): 20.0
Total project cost (EUR): 149900.0
EU funding (EUR): 149900.0
Participants: 1
Project status: CLOSED

Protein ubiquitylation plays a key role in determining the function and fate of proteins in virtually every biological pathway. The deregulation of such fundamental processes causes various diseases, such as cancer, neurodegeneration and inflammation. Understanding the impact of ubiquitylation is therefore critical for improving human health and welfare. Ubiquitin signalling is predominantly mediated by polyubiquitin chains of distinct linkages. Yet, this process is still poorly understood, largely due to a complete lack of methods for the manipulation of ubiquitin linkage. Here we propose to overcome this problem by establishing an inducible system for substrate- and linkage-selective polyubiquitylation of any target protein in vitro or in living cells. This innovative research tool, which we have named the “Ubiquiton” system, is based on a set of recombinant, tailor-made ubiquitylation enzymes in combination with appropriate tags appended to the desired substrate proteins. Having demonstrated feasibility of the method in principle, we now aim at developing the system for general use as a research and discovery tool kit for molecular biology and biotechnology. To this end, we will design expression constructs for a range of experimental systems and subcellular compartments and demonstrate the versatility of the method in different cell types, verifying its applicability in compartment-specific processes in the nucleus, the cytoplasm and at internal membranes. The Ubiquiton system will enable researchers to induce linkage-specific polyubiquitylation of desired targets in vivo and in vitro, prepare polyubiquitylated proteins for biochemical analysis, identify linkage-specific interaction partners and control protein fate in living cells. It will therefore serve as an innovative research tool for any molecular or cell biologist wishing to investigate the physiology of polyubiquitylation in health and disease.

Keywords: biotechnology,research tools,posttranslational protein modifications,protein engineering,ubiquitin
COMBINING APPROACHES FOR PHOTOSYNTHETIC IMPROVEMENT TO ALLOW INCREASED SUSTAINABILITY IN EUROPEAN AGRICULTURE (CAPITALISE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Israel,Germany,Ethiopia,Germany,Germany,France,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Boosting the efficiency of photosynthesis (RIA) (H2020-NMBP-BIO-2019-two-stage, 2019)
Start date: 2020-04-01
End date: 2024-11-30
Duration (months): 56.0
Total project cost (EUR): 8917645.75
EU funding (EUR): 8573894.75
Participants: 21
Project status: SIGNED

There is a need for a ground-breaking technology to radically increase crop yields in Europe and beyond. Improved photosynthesis will be the foundation of these radical yield increases. We are an alliance of European plant breeding companies, a phenotyping technology developer and academic plant scientists. Our project aims to translate major advances in photosynthetic improvement from model plant species into three important crop species. We will capitalize on the three most promising strategies in model plants to identify the genetic resources needed to improve the photosynthetic properties of crop plants: (I) tuning of the Calvin cycle, (II) the kinetics of photosynthetic responses to changes in irradiance, and (III) tuning leaf chlorophyll content, thus providing new tools with which to increase the rate of CO2 fixation. To do so, we aim to discover the genetic basis for natural variation in traits associated with each strategy as well as use gene editing and transgenic engineering to improve photosynthesis in three major European crops: barley, tomato and maize. The findings will be used to build a complete roadmap including the feasibility of each specific technique to improve photosynthetic efficiency. Based on precedent, we expect that improving our targeted traits will result in increases in photosynthesis of 10% or more, and there will be added benefits in sustainability via better resource-use efficiency of water and nitrogen. A public dialogue programme will be used to ensure stakeholder engagement and explore further the societal limits to the acceptability of a range of technologies as potential routes to crop improvement. Looking to the 2030 horizon, this project will develop an adaptable strategy able to achieve 10% improvement in photosynthetic efficiency across a wide range of environments.

Keywords: photosynthesis,phenotyping,natural variation,plant breeding,germplasm,plant biochemistry,plant environmental physiology,biotechnology,translational plant science,socioeconomic impact
Performing Citizenship. Social and Political Agency in Non-Professional Theatre Practice in Germany, France, Britain, Sweden and Switzerland (1780-1850) (P-CITIZENS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany,Sweden,United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2393750.0
EU funding (EUR): 1905500.0
Participants: 3
Project status: SIGNED

Amateur theatre played a significant role in the formation of a modern concept of citizenship that emerged during the Enlightenment and took shape during the American and French Revolutions. Around the social activities enacted and texts performed a broad-based movement developed between 1780 and 1850 that, arguably, had more impact than professional theatre which has previously been the almost exclusive focus of theatre studies. In the period, non-professional theatre offered huge educative possibilities for the acquisition of skills and competences deemed essential to becoming a ‘good citizen’. For the first time, a historiographical research project will study European amateur theatre’s impact on social change. Five different case studies will bring distinct cultural and political contexts into the picture that determined ideas and practices of citizenship as well as theatre: 1) late-absolutist rule in Germany, 2) revolutionary shifts in France, 3) parliamentary rule in Great Britain, 4) reformed monarchy in Sweden, and 5) a contested republic in Switzerland. The study of amateur theatre in these regions will reveal the development of their citizen practices in regard to accessibility and agency, aesthetic education, institutionalisation and professionalization. Merging performance theory, cultural theory and institutional theory this project will connect the historical formation of citizenship to discourses on performativity and the building of identity through embodied practices. It will also help to foreground the role of non-professional theatre in the shaping of society. The key objectives of this project are: [1] to contribute to a historiographic shift by focusing on the ‘doing’ and performativity of theatre practices [2] to examine how concepts of citizenship emerged around theatre in Germany, France, Britain, Sweden and Switzerland [3] to analyse how non-professional theatre embraced and further developed concepts that helped to establish a citizen

Keywords: theatre history,amateur cultures,political identity
Empowering Photonics through Regional Innovation Strategies in Europe (EPRISE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Italy,Spain,Finland,Sweden,France,France,Netherlands,United Kingdom
Call: Photonics KET 2016 (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-06-30
Duration (months): 30.0
Total project cost (EUR): 1402792.5
EU funding (EUR): 1402792.5
Participants: 11
Project status: CLOSED

EPRISE project aims to promote and support Photonics as a KET with focus on Life Science applications in 4 target markets where Europe holds a leading position – Medical Technologies, Pharmaceuticals, Agriculture and Food. Companies developing photonics-based products for these markets face highly specific Go-to-Market challenges such as long time to market adoption, complex regulatory frameworks and high barriers to market entry to name but a few. They are often in need of support from public funding to help them cross the “Valley of death” between innovation ready phase (TRL 4), and investment ready phase (TRL 7). During this time, they are also in need of advice from market specific experts who can guide them on non-technological (business) topics. EPRISE consortium will organise a “European Photonics Roadshow”, a series of 7 major events hosted by European regions, with the aim of providing SMEs with concrete solutions from market experts on how to overcome market barriers and boosting collaboration along the complete value chain via pre-arranged B2B meetings. Photonics clusters involved in EPRISE have both local connections and technology understanding to set-up, together with Regional Authorities, an efficient framework that will encourage creation of funding synergies between regional and European funds in order to better exploit potential of European Photonics industry. The project aims to provide regional policy makers with an overview of funding synergies to be considered in the current or following Multiannual Financial Framework (MFF). Furthermore, the project aims to establish a formal collaboration with the ongoing European Photonics projects offering technology support (ActPhast, Pix4Life) that can address potential technology issues linked to SMEs access to market.

Keywords: european photonics roadshow,funding synergies,regional authorities,photonics for life sciences,go to market services