Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Antigenic landscape analysis of dengue virus serotypes (ALADVS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-05-01
End date: 2013-04-30
Duration (months): 24.0
Total project cost (EUR): 192836.8
EU funding (EUR): 192836.8
Participants: 1
Project status: CLOSED

Dengue is a mosquito-borne viral disease, which has become an important international public health problem. Dengue can be caused by any of the four closely related, yet antigenically distinct serotypes of dengue viruses (DENV-1, -2, 3 and -4) that are members of family Flaviviridae (genus flavivirus). DENV causes disease ranging from mild dengue fever, to the potentially fatal dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Antibodies elicited by DENV infection are a mixture of serotype-specific, serotype-cross-reactive, flavivirus-cross-reactive antibodies, including long-lasting neutralizing antibodies to homologous DENV serotype. Presence of non-neutralizing, mainly serotype-cross-reactive antibodies, enhance the infection of heterologous DENV serotype and primarily responsible for DHF/DSS. Accurate detection of anti-DENV antibodies in human sera is complicated due to the shared antigenic determinants between different flaviviruses. Antibodies induced during DENV infection have also been shown to cross-react with auto-antigens. Despite all these problems, which are associated with the specificities of anti-DENV antibodies, there are serious gaps in our knowledge on DENV B-cell immune epitopes. B-cell epitopes have been primarily identified for one serotype, DENV-2 and mainly in envelope and NS1 proteins. In this application, we are proposing a novel phage display based approach (approach described in the part B) to identify B-cell immune epitopes (linear and conformational) of different specificity (e.g. DENV-specific, DENV-serotype-specific) in the proteome of four DENV serotypes. Detailed immune epitope information for all the four DENV serotypes can contribute to understand the mechanisms of antibody protection and antibody-mediated pathogenesis triggered by infections. B-cell immune epitope information for each of the four DENV serotypes will be useful for the generation of epitope-based antigens of diagnostics and vaccine use.

Keywords: virology,flavivirus,dengue virus serotypes,humoral immune response,antibodies,pathogenesis,vaccine,diagnostics,serosurveillance,b-cell immune epitope mapping,phage display,viral proteome
High Efficiency LIght-emitters with Organic Spintronics (HELIOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-08-01
End date: 2014-07-31
Duration (months): 36.0
Total project cost (EUR): 230515.6
EU funding (EUR): 230515.6
Participants: 1
Project status: CLOSED

Organic semiconductors (OS) are organic materials with semiconductor properties. They are expected to change the electronics as we conceive it at the moment. OS allow producing flexible, large-area and low-cost devices and they are currently used in displays in mobile phones, MP3 players, digital cameras, radios, etc. Spintronics (“spin-based electronics”) is a new electronics paradigm that deals with the use of the spin of the electrons to produce devices and is expected to provide major breakthroughs in electronics. OS are particularly interesting for spintronics due to the long spin lifetimes theoretically predicted and recently experimentally measured. Only a little is known about the charge transport and even less about spin transport in these materials. Basic properties such as the spin coherence length and time still remain unknown in most of the OS. Research to understand the physical effects involved in OS spintronics is imperative in order to achieve commercially viable devices. The aim of this project is to investigate the intrinsic spin transport properties in OS and to take advantage of it to improve power consumption in light emission devices. We will investigate how the molecular order, charge conductivity and spin transport properties are correlated, and how these properties affect the light emission efficiency in order to reduce power in light emitting devices. We will use pentacene among other reasons because it shows polymorphic nature. The outgoing host is the Massachusetts Institute of Technology – MIT (USA), one of the world references in spintronics. The applicant will learn the most advanced technology in the fabrication and characterization. It will allow him to reintegrate at NanoGune (Spain) in a mature and independent position. Besides increasing his employment opportunities in university or industry, this award will contribute to further development of this area of research and related industry in Europe.

Keywords: physical sciences,experimental physics,electronic,magnetic and superconductive properties,molecular electronics,photonic components,opto-electronic components,solid state physics
The psychological construction of mental states: How the mind is realized by distributed networks in the brain. (MAPPING THE MIND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-08-01
End date: 2014-01-31
Duration (months): 30.0
Total project cost (EUR): 192471.4
EU funding (EUR): 192471.4
Participants: 1
Project status: CLOSED

Psychology studies the mind by investigating the basic processes that underlie experiences such as ‘thinking’, ‘feeling’ and ‘perceiving’. The dominant approach presumes that these mental states can be distinguished into separate psychological processes (e.g. ‘cognition’, ‘emotion’, ‘perception’) supported by functionally specific areas in the brain. The present proposal takes an innovative stance on how the brain creates the mind by proposing that mental states are constructed out of a common set of basic psychological ingredients associated with distributed networks in the brain. We hypothesize that all mental states, including emotional states (e.g. anger or fear) and cognitive states (e.g. a state of concentration or an experience of beauty), are ‘constructed’ out of a pantry of basic ingredients. The present proposal will investigate how the brain realizes mental states in two imaging experiments. In the outgoing phase we will investigate the active brain networks that underlie the construction of mental states following the manipulation of interoceptive sensations. This phase will consist of a visit to the Interdisciplinary Affective Science Laboratory located at Northeastern University, Boston, United States. During this phase the applicant will receive excellent training in functional brain imaging techniques at the Martinos Center for Biomedical Imaging. The knowledge and experience that is obtained in this phase will be implemented in a second imaging experiment that will investigate the active brain networks that underlie the construction of mental states following the manipulation of exteroceptive sensations. This experiment will be executed at the Department of Social Psychology at the University of Amsterdam (UvA), The Netherlands. The present project will contribute to the ambitions of the UvA to become one of the leading imaging centers in Europe, and to the career goals of the applicant to become a successful neuroimaging scientist.

Keywords: mental states,emotion,affect,the body,sensations,conceptual knowledge,brain imaging,neuroscience,affective science
Context dependent sexual selection and the dynamics of colonisation (ADMIXTURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-04-14
End date: 2013-04-13
Duration (months): 24.0
Total project cost (EUR): 202049.6
EU funding (EUR): 202049.6
Participants: 1
Project status: CLOSED

One of the main goals of evolutionary biology is to understand the causes and consequences of genetic and phenotypic diversity. A key factor in this process of diversification is the ability of individuals to invade, colonize and adapt to novel habitats. A common feature of colonisation events is the introduction of animals from multiple source populations. Such genetic admixture can have important implications for both the ecological and evolutionary potential of introduced populations, through increases in genetic and phenotypic variance. Despite this, the impact of admixture on the fitness of introduced populations has received little empirical validation. The key reason for this is a lack of studies which link genetic diversity of introduced populations and the agents of selection acting on that diversity. This proposal is an ambitious, but highly achievable, development of a novel and innovative multi-disciplinary research agenda aimed at addressing this fundamental issue in evolutionary biology. Specifically, I will combine genetic, physiological, and behavioural techniques in natural, semi-natural and laboratory settings using the invasive wall lizard, Podarcis muralis, to examine the genetic context dependence of sexual selection and its role on population persistence and evolutionary diversification during colonisation. Specifically, I will experimentally manipulate the genetic admixture of semi-natural populations to provide direct tests of the strength, direction, and targets of sexual selection under different genetic contexts during colonisation events. This data will be used to parameterize an individual-based simulation model to predict how sexual selection can affect the probability of colonization of novel habitats under low versus high genetic diversity, and to generate predictions about the evolutionary dynamics during range expansion.

Keywords: evolutionary biology,biodiversity,invasion,causes and mechanisms of loss,behavioural biology
Control of Microtubule Nucleation and Dynamics in Plant Cells (COMNADIPC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2012-03-14
End date: 2014-03-13
Duration (months): 24.0
Total project cost (EUR): 280680.0
EU funding (EUR): 280680.0
Participants: 1
Project status: CLOSED

During land plant evolution, genetic and functional changes of regulatory mechanisms drive morphological innovations. One of such innovations is the loss of centrioles and the gain of properties of plant microtubules that allow them to self-nucleate in acentriolar cells. The nature of this proposed research is to study the evolution of the microtubule-organizing gene network during the conquest of land by plants. It, in particular, has been still unclear that how the components of the complex system of genes that control microtubule nucleation and dynamics have changed and the relationship between these changes and the loss of centrioles. The moss Physcomitrella patens contains both acentriolar cells and centriolar cells. Recently a novel land plant-specific microtubule-associated protein, EDE1, are identified from an angiosperm Arabidopsis thaliana and P. patens, and is a good candidate for probing microtubule organisation in acentriolar cells and centriolar cells due to its role on microtubule nucleation. Buildling on this preparatory work, the current proposal will address the two main goals: firstly, to understand the biological and molecular functions of PpEDE1, particularly in acentriolar cells and centriolar cells, and secondly to estimate functional changes of plant MAPs including PpEDE1 related to innovations of the microtubule organisation in plant cells. This will be done using two different species, the moss P. patens and the angiosperm A. thaliana, and a range of approaches, from the reverse genetics to the biochemical technique, by addressing the following objectives: 1.1 How does PpEDE1 affect microtubule function? 1.2 Does PpEDE1 localise on cortical or mitotic microtubules in the moss? 1.3 Is PpEDE1 found in centriolar or acentriolar cells? 1.4. Was EDE1 gene recruited to function in the sporophyte and endosperm of higher plants during the metamorphosis of the plant body associated with the colonization of land?

Keywords: plant science,evolution of land plants,moss,angiosperm,microtubule nucleation and dynamics,microtubule-association protein
Mechanisms of stem cell proliferation and senescence in the aged and damaged mouse brain (AGING STEM CELLS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-01
End date: 2014-11-12
Duration (months): 24.0
Total project cost (EUR): 195766.4
EU funding (EUR): 195766.4
Participants: 1
Project status: CLOSED

Stem cell self-renewal is a consequence of the ability to proliferate indefinitely while maintaining pluripotency. In the adult brain, neural stem cells continuously produce neurons, and its importance for memory and repair after neurodegeneration and brain damage has been extensively investigated. However, adult neurogenesis is limited and significantly decreases throughout life. With aging, increased senescence greatly restrains the neurogenic potential of aged stem cells. Senescence induction is critically controlled by the INK4a/Arf locus, but the mechanisms of senescence induction are largely unknown. It is essential to understand the mechanisms involved in the control of stem cell proliferation and senescence for the development of stem cell-based therapies. The host laboratory identified that embryonic and peripheral neural stem cell proliferation is regulated by a novel mechanism that involves S-phase cell cycle arrest, GABA signaling and the histone variant H2AX (Andäng et al Nature 2008). This proposal aims to investigate whether GABAAR and H2AX-mediated modulation of stem cell proliferation is a factor in age-related decline in neurogenesis, and if this pathway could be modulated towards boosting neurogenesis following neurodegeneration or damage. H2AX is also involved in senescence, being activated following telomere erosion. We propose to investigate the mechanisms of senescence induction and the interaction between critical regulators of cell cycle. This will provide new information on the conserved and unique pathways involved in the control of stem cell proliferation and senescence. The investigation of the mechanisms involved in age-related neurogenic decline and how neurogenesis can be boosted may open the way for new clinically relevant strategies increasing self-repair following brain damage and neurodegeneration.

Keywords: neuroscience,aging,gabaa receptor,stem cell proliferation,neurogenesis,neurodegeneration,self-repair,stroke,senescence
Polymer Microarrays – Identification of Substrates for Cellular Control and Enrichment (MICCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-07-13
End date: 2013-07-12
Duration (months): 24.0
Total project cost (EUR): 210092.8
EU funding (EUR): 210092.8
Participants: 1
Project status: CLOSED

Summary: Over the past decade the Bradley group has developed a variety of sophisticated high-throughput approaches for the preparation/fabrication of polymer microarray platforms (with arrays of several thousand individual polymers printed onto standard microscope glass slides and their subsequent biological screening and evaluation. Thus slides can be interrogated with a variety of cells (mammalian, bacterial or even parasites) with subsequent high-content screening, allowing the identification of a specific polymer or polymer blend that binds or otherwise modulates cellular function. This platform allows polymers to be rapidly identified, as novel substrates, which can bind cells in a selective manner, allows proliferation of defined cell populations and control cell fate, while offering the possibility of identifying defined synthetic matrices that might replace animal derived substrates like gelatine or collagen or discovering materials that can be coated onto mesh and used in filtration devices. Using this approach the Bradley group have discovered a variety of new materials, three of which are now undergoing in vivo evaluation and two are undergoing commercialization (as well as delineating their modes of action). They are currently collaborating with over twenty research groups using this technology and have published extensively. This forms the ethos of this proposal and opens a door on broad numbers of EU priority areas. No other group in the EU is working on such a far reaching polymer discovery strategy or has discovered such a plethora of novel polymers for such a range of practical applications. It is in this area that I wish to immerse myself, while bringing my own skills associated with polymer chemistry and application in the area of drug release.

Keywords: health sciences,physical sciences,technological sciences
Academic Researchers Driving Innovation Systems (ARDIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 217245.0
EU funding (EUR): 217245.0
Participants: 1
Project status: CLOSED

Academic researchers form a crucial part of innovation systems but research so far leaves room for the following three questions: how does social capital of academic researchers co-evolve with the use, creation and dissemination of knowledge and innovation? Two, how do academic researchers’ innovation systems function at the regional, national and global level? Three, are the research activities and goals, the knowledge accumulation and the networks of academic scholars characterized by their technical disciplines? In particular, the applicant aims at developing a taxonomy of academic researchers that goes beyond basic and applied research. The approach used for the project has three major distinguishing characteristics: One, it is a comparative approach as the applicant will analyse the situation at five leading European universities of science and technology. These universities form the IDEA league and include a British, Dutch, French, German and Swiss partner. Two, the approach is interdisciplinary as the applicant will join the perspectives of two disciplines, i.e. Economic Geography and Economics of Innovation. Three, the applicant uses a theory-driven empirical approach by combining quantitative, i.e. social network analysis and bibliometric analysis, and qualitative research methods in an innovative way. The approach taken mirrors the aim of the research training project. The applicant has a strong theoretical background in Economics of Innovation and empirical experience in quantitative research methods. Her stay at the RWTH Aachen University would enhance her knowledge of Economic Geography and of qualitative research methods. The insights regarding patterns, dynamics and effects of knowledge-intensive networking of academic researchers will hint at chances and bottlenecks in innovation systems. They will help academic researchers, university management and policy makers to improve the research efficiency and output of the European Research Area.

Keywords: knowledge economy,social shaping of technology
Circulating Knowledge, Making Europe. Cultural and scientific communication between Rome and the Holy Roman Empire during the Thirty Years War (CIKME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-08-01
End date: 2013-07-31
Duration (months): 24.0
Total project cost (EUR): 217745.0
EU funding (EUR): 217745.0
Participants: 1
Project status: CLOSED

The project sets out to investigate the spaces and borders of knowledge circulation between Rome and the Holy Roman Empire, during the decades leading up to the outbreak of the Thirty Years War and witnessing the growth of confessional antagonisms (1590-1648). Major aim is to chart the texture of such a complex cultural space. The result will be a highly composite picture, strongly influenced by the dynamics of power which articulated in Europe, as well as beyond it. The project conceives in fact the relationships between Rome and the German world as hardly bilateral. On the contrary, the research strategy intends to encompass and fully investigate the maze of connections shaping the global dimension of knowledge circulating across the Alps. Engaging with a differentiate scholarships, the project argues for a more sophisticated understanding of circulation as the very ‘site’ of knowledge making. The approach to cultural exchange will be therefore sharpen up, focusing on the continuous reshaping of knowledge through mobility. Such a research agenda requires the project to deal with a complex spatial configuration, arguing for the need of a stronger geopolitical sensibility. Facing macro-scale issues, the project sets the investigation at a more empirical level of analysis, by concentrating on social actors and practises. Cultural brokers will be regarded as a valuable entry-point. In relation to them, the project proposes a dual-track inquiry focusing 1. on the role as go-betweens played by Germans who settled in Rome, as well as by intellectuals and practitioners fostering contacts between their German courts and urban cultural milieus and the city of the pope. 2 on ‘German’ Jesuits. The project plans to deal with different forms of cultural communication, paying specific attention to circulation of natural knowledge.

Keywords: humanities,early modern history,transnational history,cultural history,europe,holy roman empire,rome,confessionalization,cultural exchange,natural knowledge,cultural objects,broker,jesuits