Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Historical Research and Data Processing on Ancient Vietnamese Inscriptions (VIETNAMICA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France,Canada
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 2491583.5
EU funding (EUR): 924441.5
Participants: 2
Project status: SIGNED

Driven by a general movement in Asia to invest in Classical studies, the project Vietnamica aims for a historical and linguistic study of ancient, invaluable Vietnamese inscriptions, while also helping to determine a ground-breaking method for the use of epigraphic resources. In partnership with Han-Nôm Institute and Vietnam National University, the project is motivated by the recent divulgence of 40,000 paper stampings that reproduce the inscriptions engraved on the surfaces of 25,000 steles erected between the 16th to 20th century in Vietnam. These inscriptions, written in a complex Chinese embedded with the local vernacular, are conserved at the Han-Nôm Institute in Hanoi. Offering an unexpected counterpoint to existing official sources, these inscriptions prompt the study of rural inhabitants, monks and notables across an era of five centuries through their very own language. The project will produce a series of studies on popular Buddhism and its connection to the ancestor cult, donations and the role of women in the economy of gifting, and monetization and land property. Based on these themes, the project will record and analyze the logographic processes that the Vietnamese once used to transcribe the language they spoke. Such research - close to the field and to its people - was once a dream for scholars, and is now possible due to the corpus of stampings available. Characteristic of local histories, information is dispersed in fragments all throughout the corpus and it is first necessary to categorize the existing inscriptions. Vietnamica will rely on tools available through digital and computational humanities to construct a database of the stampings, connect it to data mapping, and on a more technical level, proceed with a segmentation of the text to allow for the automatic identification of the demotic characters. The results from the project will converge on a Platform (Vietnamica.eu) that is meant to remain accessible to researchers indefinitely.

Keywords: history,donation,computational humanities,inscription
Revolutionising the world of hemodialysis with a novel, hybrid, silk fibroin/polyurethane vascular access (DIALYBRID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Vascular access is the bottleneck to long-term hemodialysis for about 2.2 million people worldwide who need this life-saving/life-sustaining therapy in case of renal failure, e.g. as a consequence of diabetes and/or hypertension. The current alternatives of vascular access suffer in fact from several limitations, e.g. the need for frequent and costly re-interventions, reduced patency, infective complications. To meet this urgent, global, clinical need, BEL proposes SAG (Silkothane® Arteriovenous Graft), an innovative, hybrid, semidegradable, nanostructured vascular access, manufactured by electrospinning using Silkothane®, a silk fibroin/polyurethane blend developed and trademarked by BEL under the auspices of a MSCA action. Enabling early cannulation and easy placement, as well as remodeling, patency, and integration on the long term, SAG will revolutionize the scenario of hemodialysis vascular accesses worldwide by: reducing the frequency of complications and re-interventions (thus health costs); granting broader access to hemodialysis; improving the patients’ quality of life, enabling them to live longer as functioning members of the society. SAG has reached TRL 6. Phase 1 would allow BEL to verify the soundness of SAG’s venture (with a Business Plan and an IP Management Plan), and to de-risk the technological viability of the industrialization (delivering Essential Requirements, Risk Analysis, Validation Master Plan, Industrialization Plan), in view of future clinical studies, certification and commercialization. SAG represents for BEL an important opportunity to diversify its product portfolio, enter the market of Advanced Materials, experience growth in productivity and competitiveness and create new jobs. As the commercial potential of SAG is estimated to be around 28 million € in 2025 and 54M€ in 2030, in 2025 the SME would experience an increment in turnover of about 470%, and a 36% increase (from 28 FTEs to 38 FTEs) in highly skilled human resources.

Keywords: silk fibroin,polyurethane,vascular access,hemodialysis,vascular graft
Molecular mechanisms controlling exit from mitosis (COHEMEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

Cancer, the uncontrolled division and spread of cells, represents one of the most important causes of death in Europe and all over the world. Understanding how cells control their division is the key to comprehend and cure cancer. Eukaryotic cells divide through mitosis to produce new cells with identical DNA. Yet, mitosis has to be ended for the two cells to be separated to become individual cells with the capacity to further divide. This occurs by a process called mitotic exit. Mitotic exit is a critical step during cell division. Failure to control mitotic exit is the key cause of aneuploidy and genomic instability, which are hallmarks of cancer. Therefore, gaining a comprehensive knowledge of mitotic exit regulation will have significant impact on understanding and treatment of cancer. In this project, the researcher will uncover a novel mechanism that control exit from mitosis mitotic. This novel regulation has the potential to define a molecular target to fight cancer in long term. Researchers previous research experience puts her in a unique position to perform this project. This fellowship will also allow the researcher to build a successful academic career, to acquire new expertise and soft skills, and to establish future collaborations through dissemination, communication and training. Furthermore with this fellowship, researcher will help increase public awareness of science through outreach activities.

Keywords: mitosis,mitotic exit,mitotic control,chromosome segregation,cell cycle
Installed adVAnced Nacelle uHbr Optimisation and Evaluation (IVANHOE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy,Germany,Sweden,Netherlands
Call: UHBR Installed Advanced Nacelle Optimisation and Evaluation Close Coupled to Wing (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2023-10-31
Duration (months): 49.0
Total project cost (EUR): 3514833.75
EU funding (EUR): 3514833.75
Participants: 6
Project status: SIGNED

The introduction of UHBR engines poses new challenges on optimal nacelle design, both in geometry and in location. In response to the topic CfP09 CS2-LPA-01-67, the IVANHOE project will address this challenge, resulting in a new multi-fidelity optimisation method, validated by advanced wind tunnel experiments. A consortium of an SME, an industry, an R&D institute and 3 universities with complementary skills will produce this result in close coordination with the topic manager in 36 months, asking for a grant of € 3 514 834. Coordinator CTH will provide the design envelope and safeguard thrust/drag performance, HIT09 and UNIPD will jointly optimise a rapid design loop to down select options. TUB will validate the resulting design options with a high fidelity CFD code, complemented by a high fidelity wind tunnel experiment of a Deharde powered nacelle model in DNW’s High Speed Tunnel. The project will advance the state of the art in nacelle design by smart use of various fidelity level aerodynamic modelling tools enabling fast iterations and down selection of nacelle geometries and locations. Wing/nacelle interference will be taken into account. This method will be validated by wind tunnel experiments with new and advanced wind tunnel model and measuring techniques. The result of the nacelle optimisation for an UHBR installation on the Common Research Model will be delivered in full compliance with the call. Moreover, IVANHOE’s will provide an improved design method, tools and facilities for use by the European aviation industry for future aircraft projects, unlocking the full potential of CO2 reduction of UHBR engines while increasing competitiveness by reducing costs for design and testing.

Keywords: uhbr,nacelle,optimisation,wind tunnel,high fidelity,multi fidelity,design,book keeping
Beta cell GABA secretion: route, physiological function, and potential for pharmacological modulation in diabetes therapy (ISLET GABA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-11
End date: 2023-10-10
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

According to the World Health Organisation, diabetes affects 422 million people worldwide, over 8% of the entire adult population. The progression of both type 1 and type 2 diabetes is characterised by a decrease in the number and function of beta-cells within pancreatic islets. It has recently been demonstrated that the neurotransmitter γ-aminobutyric acid (GABA), which is produced and secreted from beta cells, is able to slow and even reverse this loss of beta cell capacity. This finding has caused great excitement as treatments which directly address beta cell degeneration would revolutionise diabetes therapy. In order to realise this potential, it is essential that we understand the biogenesis, storage, and secretion of GABA in addition to its functional effects upon islet cells. I therefore propose to characterise a suggested route of GABA secretion from beta cells, assess its role in signalling between islet cells, and identify pharmacological modulators of GABA secretion. This study will be hosted by Patrik Rorsman (University of Gothenburg) with a secondment to AstraZeneca (Mölndal). This interdisciplinary study will combine my experience of applying cutting edge proteomics and genetic editing techniques to the study of protein trafficking with my host's world-leading expertise in islet cell physiology. Successful completion of the proposed work program will reveal fundamental details of islet GABA signalling and likely identify new therapeutic targets for the treatment of diabetes. Furthermore, during a cross-sectorial secondment to AstraZeneca I will carry out a high-throughput phenotypic screen to directly identify small molecule modulators of beta cell GABA secretion.

Keywords: gaba,beta cell,secretion,synaptic like microvesicle
Design, fabrication and optimization of a novel integrated UV-microwave assisted catalytic reactor for the continuous flow treatment of wastewater (UVMWREACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

UVMICROCAT uses an innovative catalytic mesh assisted by a combination of UV and microwave technology for fast and effective treatment of large volumes of wastewater for water re-use. The project proposes an environmentally-friendly, totally innovative method for the treatment of toxic and recalcitrant contaminants in wastewater by enhancing the rate of a novel heterogeneous catalytic treatment process using microwave energy and ultraviolet radiation. The modified PAN catalysts developed at DMU has eliminated the need for iron removal post treatment and has broadened the pH range of application, whilst enabling continuous flow processes favoured by industry. In recent years, several reports have demonstrated the use of microwave and ultraviolet radiation to promote the oxidative degradation of bio-refractory wastes due to their advantages of speeding up the reaction, high-efficiency with no pollution to the environment. Nevertheless the use of microwaves in catalysis and in the water and wastewater industry remains at laboratory scale and therefore requires further in depth research. The major challenges in the water/wastewater industries are centered on the poor penetration depth of microwaves. In the project, we propose to design a UV and microwave assisted reactor which overcomes this scale-up problem. The design of the scalable microwave reactor will not only add new knowledge to the sector but open up new areas of industrial application for microwaves.

Keywords: microwaves,magnetron,heterogeneous oxidation catalysis,photo fenton s,reactor design,computer simulation of microwaves,wastewater,water re use
The MareNostrum Experimental Exascale Platform (MEEP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Spain,Croatia,Türkiye
Call: Advanced Experimental Platform Towards Exascale (H2020-JTI-EuroHPC-2019-3, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 10378125.0
EU funding (EUR): 5150000.0
Participants: 3
Project status: SIGNED

The MareNostrum Experimental Exascale Platform (MEEP) is a flexible FPGA-based emulation platform that will explore hardware/software co-designs for Exascale Supercomputers and other hardware targets, based on European-developed IP. MEEP provides two very important functions: 1) An evaluation platform of pre-silicon IP and ideas, at speed and scale and 2) A software development and experimentation platform to enable software readiness for new hardware. MEEP enables software development, accelerating software maturity, compared to the limitations of software simulation. IP can be tested and validated before moving to silicon, saving time and money. The objectives of MEEP are to leverage and extend projects like EPI and the POP2 CoE in the following ways: ● Define, develop, and deploy an FPGA-based emulation platform targeting European-based Exascale Supercomputer RISC-V-based IP development, especially hardware/software co-design. ● Develop a base FPGA shell that provides memory and I/O connectivity to the host CPU and other FPGAs. ● Build FPGA tools and support to map enhanced EPI and MEEP IP into the FPGA core, validating and demonstrating European IP. ● Develop the software toolchain (compiler, debugger, profiler, OS, and drivers) for RISC-V based accelerators to enable application development and porting. MEEP will deliver a series of Open-Source IPs, when possible, that can be used for academic purposes and integrated into a functional accelerator or cores for traditional and emerging HPC applications. This is an exciting target for IPs generated from projects like EPI, and an IP source for follow-on projects as well. MEEP will provide a foundation for building European-based chips and infrastructure to enable rapid prototyping using a library of IPs and a standard set of interfaces to the Host CPU and other FPGAs in the system using the FPGA shell. In addition to RISC-V architecture and hardware ecosystem improvements.

Keywords: exascale,risc v,fpga
LIght-responsive GrapHene-based inTerfaces for Electrical STimulation (LIGHTEST)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Neurological disorders are a global leading medical and societal challenge, affecting particularly the aged population. Because of the lack of efficiency of pharmacological options, alternatives such as electrical stimulation using implanted electrodes has gained popularity. However, this strategy lacks spatiotemporal control over the stimulation of specific neural circuits, of which no biochemical information can be acquired. Recent breakthroughs in non-genetic, light-mediated electrical stimulation have shown promising results towards minimally invasive devices with controllable performance following exposure to near infrared (NIR) light. The LIGHTEST project proposes an innovative neural interface constituted by electrodes combining graphene with upconversion nanoparticles (UCNP), which will convert NIR light into electricity with spatiotemporal control. We will use novel tools to screen formulated graphene-UCNP complexes and evaluate their biological interactions in the presence of NIR light (e.g. high-throughput screening, RNA sequencing). This project counts on the applicant’s knowledge in synthesis, characterisation and biological evaluation of graphene-based materials, alongside the expertise of Dr Lino Ferreira in the formulation of light-responsive nanomaterials and their in vivo interactions, in combination with the experience in optogenetic engineering and mechanistic understanding of light-mediated stimulation in the brain from Dr João Peça at the Host institute. This project will contribute to the establishment of the applicant in Portugal as an independent researcher in nanomedicine, which is a strategic field that will boost European competitiveness in the development of novel therapies and inspire new generations for a better healthcare.

Keywords: optoelectronic stimulation,upconversion nanoparticles,neuromodulation,biocompatibility,near infrared light
European training and research network on Autonomous Barges for Smart Inland Shipping (AUTOBarge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Norway,Norway,Belgium,Sweden,Norway,Belgium,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 4090128.48
EU funding (EUR): 4090128.48
Participants: 10
Project status: SIGNED

According to the European Commission, passenger transport is projected to increase 42% by 2050, and freight transport up to 60%. Needless to say, this puts an enormous burden on transport networks and our environment. Compared to other modes of transport – which often face congestion and capacity problems – inland waterway transport is characterised by reliability, energy efficiency and a capacity for increased use. More than 37,000 km of waterways connect hundreds of cities and industrial regions in Europe. In the EU, 13 countries share an interconnected waterway network, highlighting the potential for increasing the modal share of inland waterway transport. This will not happen unless we can make inland waterways economically competitive. However, with crew costs accounting for 60% of the total cost, autonomous inland vessels represent an exciting disruptive technology. AUTOBarge is about seizing an opportunity. Europe’s waterways are a vital resource that we have underused for most of the last century. Now, with the possibility for mass autonomous shipping, these canals and rivers offer a network that we can exploit without damaging the environment to the extent of new roads and aircraft runways. But to be able to do this we need new people with new skills. These innovators must be experts in remote control, monitoring, smart logistics, regulatory aspects, and many more areas associated with the complexity of inland shipping. The 15 early-stage researchers recruited to AUTObarge will begin this transport revolution.

Keywords: autonomous vessels,inland waterways,sense understand decide act