Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microreactor-assisted Maillard reaction to valorise rapeseed cake protein for the production of plant protein emulsion beverages (MiMaPro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 2
Project status: SIGNED

The substantial amount of agro-industrial by-products, such as rapeseed cake, poses an environmental concern in the EU. MiMaPro is a multidisciplinary project that aims to valorise rapeseed cake by modifying the structure of rapeseed cake protein (RCP) and enhancing its value as a plant protein beverage, both in the laboratory and pilot-scales. This strategy aligns with the EU's Circular Economy Action Plan and meets consumer demand for plant-based diets. Novel approaches will address techno-functional challenges, including low solubility and emulsification of RCP: a) Microreactor-Assisted Maillard: MiMaPro's originality lies in improving the techno-functional properties of RCP by employing a microreactor-assisted Maillard reaction to create conjugated RCP. A microreactor will be used to accelerate the reaction while managing the progression to advanced glycation, finally improving solubility and emulsification. b) Spray Drying: MiMaPro will employ optimised spray drying (as a scalable process) to produce Maillard conjugated RCP powders with minimal variation from freeze-dried powder. c) Emulsion Creation: Conjugated RCP will be partially blended with pea protein to create a hybrid protein with a balanced amino acid profile. An emulsion stabilised by this blended conjugated RCP-pea protein will be prepared, followed by kinetic stability determination and bioavailability assessment of emulsion-loaded vitamin D3. d) Upscaling and Prototype Generation: MiMaPro will scale up the microreactor and spray drying based on the knowledge gained from steps a-c to produce a plant protein emulsion beverage prototype. The majority of MiMaPro will be conducted at UL (host). The fellow will participate in a secondment at Ulster University to study vitamin D3 bioavailability and undertake an industry placement at CPI to upscale the process and develop a prototype. The fellow will also receive a comprehensive training plan that includes both scientific and transferrable skills.

Keywords: maillard reaction,microreactor,plant proteins,rapeseed cake protein,emulsion beverage
Break-Through Innovation - R D Misallocation, Green Innovation, and the AI Revolution (BTI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2438750.0
EU funding (EUR): 2438750.0
Participants: 1
Project status: SIGNED

This research project will confront theory and data to analyze the underpinnings and the effects of breakthrough innovation. We explore three main questions. First question: How should we design R&D policy to induce breakthrough innovation? Why do we observe more incremental innovations in Europe than in the US? We shall address this question using an extension of the Schumpeterian growth paradigm where both the size and sources of markups differ across firms. Firms may be big as a result of breakthrough innovation, or for other reasons, including the lack of competition. In this part of the project, we shall provide new tools to empirically distinguish between these different sources of rents, with implications for the optimal design of R&D policy and competition (e.g. M&A) policy. Second question: How can we further stimulate radical green innovation to help solve climate change? It has been shown in previous work that firms whose innovation has focused on polluting technologies in the past prefer to innovate in polluting technologies in the future. Here we will extend the literature on green innovation in three directions: first, by analyzing green technological transition along a supply chain, second by looking at the relationship between green innovation and credit access, and third, by looking at the implications for the green transition process, of consumers’ non-homothetic preferences for quality goods that are more reliant on service labor, and therefore exhibit a comparatively lower environmental footprint. Third question: What are the growth and employment effects of the AI revolution, and which policies – if any – can maximize the growth and employment potential of AI? Our analysis will rely on an extended growth model where AI can automate tasks both, in the production of goods and services and in the production of ideas.
Coherent Hypothesis Tests for Experimental Research (BAYESIAN BOOST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Across psychology and allied disciplines, the statistical analysis of experimental data hinges on a comprehensive set of "frequentist" techniques that culminate in confidence intervals and p-values. These frequentist analysis-of-variance (ANOVA) techniques form the fossilized core of what is taught, practiced, and expected. This proposal seeks to break the mould and develop a comprehensive set of alternative "Bayesian" techniques that are attractive, interpretable, practically feasible, and ultimately normative as a supplement to the traditional approach. This requires that the existing set of Bayesian techniques are greatly expanded, that the resulting advantages are highlighted and demonstrated on published data, and that the methodology is supported by established open-access software that is easy to use (i.e., R and JASP; jasp-stats.org). As a result, the field stands to gain a mature alternative statistical methodology that produces new insights and allows a coherent and diagnostic test of the experimental hypotheses of interest. Key Bayesian advantages include the ability to discriminate "absence of evidence" from "evidence of absence", the ability to model-average across multiple candidate models (e.g., to account for violations of assumptions), the ability to quantify and monitor evidence as the data accumulate, and the ability to accommodate prior knowledge (e.g., to encode past empirical information in a prior distribution). The robustness of the proposed procedures is assessed using a novel "many-statisticians" approach, and the potential for broad adoption is enhanced by the creation of tutorial materials and a continually expanding online library of annotated examples. Although the focus of the proposal is on applications in experimental psychology, the envisioned methodology will be useful for other experimental disciplines as well.

Keywords: bayesian hypothesis testing,bayesian model comparison
Monitoring mentAl healTh in brEast canceR (MATER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

One over three women with breast cancer will develop mental health issues, adding the burden of a deterioration of their quality of life to the management of cancer itself. The objective of the MATER project is to improve the detection and monitoring of mental health in women with breast cancer by leveraging symptom networks and vocal biomarkers. The project addresses three research questions. We first hypothesize that the use of symptom networks will allow a better understanding of the links between depressive symptoms, fatigue and a decreased quality of life, and identify the most important symptoms in the deterioration of the mental health of these women. We also assume that automatically estimating these symptoms using voice descriptors extracted from real-life recordings and machine learning pipelines will make it easier to monitor them in the patients' homes. Finally, we hypothesize that the use of a Bayesian network algorithm combining the symptom network and the voice-based symptom estimations will allow a more accurate joint estimation of these symptoms - and thus improve the identification and monitoring of mental health-related symptoms in women with breast cancer. The interdisciplinary MATER project is based on Colive Voice, a unique dataset of clinical and voice data and leverages both the complementary host's and supervisor's extensive experience in digital and personalized health and the applicant's knowledge of vocal biomarker design and machine learning, mental disorder semiology, and Bayesian networks. This project will allow the applicant to improve his skills in voice signal processing, precision health (in particular in oncology), but also in scientific project management and in research valorization, creating an international network and elevating his profile to such levels as to accelerate his access to high-level academic positions.

Keywords: symptom networks vocal biomarkers
Ocean Crime Narratives: A polyhedral assessment of hegemonic discourse on environmental crime and harm at sea (1982-present) (OCN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

With the latest international Law of the Sea (UNCLOS 1982), narratives on environmental crimes and harms at sea have changed their views of ocean governance, sustainability, and human rights, and are now shaping an international, hegemonic discourse. A growing, under-examined corpus of contemporary literary and filmic narratives discusses environmental criminality at sea as subject to contested international and state jurisdiction, harmful to oceanic sustainability and threatening human rights, and uncertainly poised between crime and harm. Literature and film are only part of the discourse around environmental criminality at sea, since policymakers, lawyers and scientists are its main producers. How do discourses in the cultural and scientific realms co-create conceptions, arguments and ideas that underpin the actual international regulations and policy negotiations around environmental crime and harm at sea? OCN responds to this new challenge with three objectives: 1) to analyze the narratives around environmental crime and harm at sea in a new, hitherto unexamined corpus of post-1982 literature and film; 2) to conduct a novel narrative analysis of environmental sea crime and harm discourses aiming for dissemination and governance from the perspective of oceanography, green criminology, and political ecology; 3) to produce a polyhedral assessment of hegemonic, international discourse on environmental crime and harm at sea today. OCN examines a post-1982 corpus of literary, filmic and expert narratives dealing with three areas of harm and crime: a) exploitation of biological and mineral marine resources; b) toxic waste and plastic dumping; c) harmful climate-change effects on oceanic ecosystems. The project tests an interdisciplinary analysis of discursive practices to provide a fresher, critical view of hegemonic, international environmental crime discourses at sea, which determine definitions of criminality and aim to safeguard the future sustainability of our oceans.

Keywords: narrative analysis,oceans,environmental crime
METABIOGEL (Metabiogel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Our proposal aims to develop a new class of biobased composite hydrogel materials specifically designed for vibration damping and energy absorption applications. These biobased composites will be sourced locally from various regions worldwide and will serve as 3D printable feedstock. The new hydrogels will be engineered to withstand temperature and humidity ranges beyond typical room conditions and provide superior damping performance compared to fossil elastomeric materials available. As fully biodegradable and bio-sourced materials, they will effectively replace fossil-based materials currently used in commercial damping technologies.
Digital Assembly 2023 (DA23)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Coordination and support actions
Countries involved: Sweden
Call: Digital Assembly - Presidency Event 2023 (HORIZON-CL4-2022-DIGITAL-ASSEMBLY-IBA, 2022)
Start date: 2023-01-01
End date: 2023-09-30
Duration (months): 9.0
Total project cost (EUR): 1058450.0
EU funding (EUR): 500000.0
Participants: 2
Project status: CLOSED

The Digital Assembly is an annual event hosted by the European Commission and the holder of the spring presidency of the Council of the European Union. It is a forum to address important issues of the digital transition. The Digital Assembly of 2023 (DA23) will be hosted by the Swedish presidency at Scandinavian XPO during Q2 2023. The Swedish Presidency seeks to build a conference program that addresses current EU initiatives as well as ongoing debates on the conference theme. Thus, the conference will provide an opportunity to showcase the status and potential of initiatives within the Digital Decade, the EU Cyber Security Strategy as well as the Twin transitions. The Swedish Presidency also aims to build upon related conversations previously held within the Troika, such as the Digital Assembly 2022 conference in Toulouse and the conference EU Secure and Innovative Digital Future held in Prague 2022. However, given the quickly changing discursive context within which the conference will be situated, the project management will closely follow the development in related fields and tailor the program accordingly. Objective 1: To stimulate the European discourse on the EUs digital transition and cyber security by providing a platform for multistakeholder dialogue. The target group for DA23 is government officials, regulators, private sector representatives and the academia. Non-governmental organisations will also be approached to contribute their perspective on the topic at hand. EU Commissioners and the Troika ministers in the European Union responsible for digital issues will be invited, as well as high-level business and public policy decisionmakers. By bringing together a multitude of stakeholder in a quad helix constellation the project will stimulate debate, collaboration and innovation on the conference theme.

Keywords: digital transition,cyber security,open digital inner market,open society
Development of EXtracellular-based artificial bio-nanoparticles: a novel Targeted vector with high potential in cancer ThERapy (DEXTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: TERMINATED

In spite of a growing toolbox of therapies, including classical (radiotherapy, chemotherapy or surgery) and emerging (immunotherapy, precision medicine or hormone therapy) treatments, cancer is a multifaceted global health issue that continues to demand new solutions. The advent of nanotechnology has added nanoparticle (NPs)-based approaches to the available toolbox in cancer therapy. Indeed, we now have NPs with extraordinary properties, including drug loading, antibody functionalization and remote activation capabilities. However, these promising advances have so far failed to materialize in the clinic, largely due to a lack of selective delivery to tumors. DEXTER attempts to change this situation by combining recent multidisciplinary advances in the fields of nanomedicine and extracellular vesicles (EVs). Specifically, DEXTER aims to develop new procedures to create bioartificial EVs that maintain selective targeting properties after loading them with therapeutic NPs. These artificial EVs have the potential to overcome the limitations of using native EVs, whose targeting and immune system-evading properties are compromised after loading with NPs. For this, fundamental problems need to be resolved to realize their potential for application in the clinic. In particular, there is a clear lack of understanding regarding the stability of exosomes during long-term storage as well as their interactions with cells from the immune system in their application in vivo. DEXTER will shed light on the key factors that govern the fate of NPs-loaded exosomes, providing clues to modify them in order to achieve a strong enhancement of their ability for selective delivery of therapeutic loads to tumors. The developing of DEXTER in the host institution will allow me to mature and acquire new research lines, developing new competences in nanotechnology and chemical technology research, and will be crucial to encourage my independency in this stage of my career.

Keywords: extracellular vesicles,nanoparticles,targeting,cancer,immuno scape
AFRICAN SWINE FEVER PREVENTION AND CONTROL IN WILD BOAR (HOP-ON ASFaVIP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Latvia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 308262.5
EU funding (EUR): 308262.5
Participants: 2
Project status: CLOSED

African swine fever (ASF) continues to pose a significant threat to pig farming and wildlife globally, with effective vaccines still largely unavailable. The HORIZON Europe funded ASFaVIP project aims to advance the leading vaccine candidate(s) through the European Medicines Agency's licensing process and optimize vaccination strategies for wild boar and domestic pigs, considering the disease dynamics within the European Union. To achieve this, research is necessary into wild boar ecology under ASF influence and their behaviour in response to various baiting/immunization strategies. Currently, the project consortium has a strong focus on partners with capacities to provide animal trials with the final vaccine candidates and field work is focused on affected regions in Germany; however, expanding research to include additional regions with varying wild boar habitats, population densities, and ASF control strategies would better reflect the broader regional context. In this context, Latvia (BIOR) will be included in the ongoing project activities, especially work package 7. Latvia was among the first countries in the EU that were hit by ASF in 2014 and the disease is still present. Latvia is therefore best-placed to provide background for studies into wild boar biology under the influence of ASF. Moreover, Latvia has different scenarios where baiting strategies could be tested. In brief, the following objectives would be added: bait deployment trials in an ASF-endemic region with low wild boar densitiy, and field studies to improve our understanding of population dynamics and ASF epidemiology in longer-term and endemic situations.

Keywords: african swine fever wild boar ecology vaccine bait deployment
PELVIc Floor Evaluation live TRACKing – Real-time prediction of perineal trauma (PELVITRACK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,United Kingdom,Switzerland,Spain,Italy,Czechia,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-04-01
End date: 2029-03-31
Duration (months): 48.0
Total project cost (EUR): 3209102.5
EU funding (EUR): 3209102.5
Participants: 14
Project status: SIGNED

Pelvic tissues, supporting the pelvic floor, can change in physical properties during lifetime, leading to dysfunctions commonly known as Pelvic Floor Disorders (PFDs). These disorders, encompassing pelvic pain, pelvic organ prolapses, urinary or anal incontinence or dyspareunia, affect 32% females and 16% males worldwide, making it a major health concern. Various factors such as older age, menopause, obesity or intense physical activity are significant contributors. However, the occurrence of PFDs is mainly due to traumatic events. Indeed, perineal tears, taking place in 90% of vaginal deliveries (VDs), have been identified to be a high-risk factor of PFDs. As an answer, PELVITRACK’s ambition is to enable the systematic prevention of PFDs, ensuring earlier diagnosis, more reliable prognosis, and more efficient care. More specifically, the project will design a real-time turnkey lab-scale solution to monitor perineal tearing during VD and minimize pelvic traumas. This revolution in the monitoring of the pelvic floor will be achieved through a hybrid experimental and numerical approach, leveraging ex vivo data and computational modelling on pig perineum to select IDEVs (Investigated DEVices) that will be adapted and validated in vivo on animals (preclinical study) and women (clinical studies). To achieve its ambitious goal, PELVITRACK gathers a unique interdisciplinary consortium of 11 partners including renowned research institutions, universities, hospitals and SMEs to cover all the required scientific expertise and knowledge in mechanics, computer science, electrical and thermal engineering, acoustics, optics and obstetric physics. Exploring new technologies to predict perineal trauma in real time, PELVITRACK delineates a high-risk/high-gain proposal that will significantly contribute to the health and well-being of females in Europe and beyond.

Keywords: pelvic floor disorder,perineal trauma,obstetrics,gynecology,mechanical modeling,mechanical behavior,perineal tissue,prognosis