Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional Microscopy of Individual Neurons in the Living Human Retina (FunMicroRetina)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999998.0
EU funding (EUR): 1999998.0
Participants: 1
Project status: SIGNED

Subcellular, functional imaging of neurons in living humans could revolutionize biomedical research and prove valuable in the clinic. With optical techniques, subcellular resolution is achievable and although the eye provides optical access to the retinal neurons, the size of the eye’s pupil currently prevents subcellular resolution in all optical imaging techniques of the living retina. In this project, I will develop a novel tomographic microscopy technique and use it to demonstrate at least a 4-times better resolution for retinal tomography compared to the state-of-the-art. For the first time, a resolution below 1 μm will be achieved for imaging of the living human retina. For this, I will use innovative structured illumination and reconstruction techniques that project coherent light through the sclera (transscleral) or the skull (transcranial), allowing for unprecedented resolution in 3-D retinal tomography. My method will use interferometric detection with noiseless amplification and exploit recent computational methods to reconstruct and correct the data. In addition to morphology, my technique will also assess the functional state and activity of neurons after optical stimulation of the photoreceptors. For this, I will harness changes in phase and speckles of the image data caused by physiological processes. This imaging will be non-invasive and without contrast agents. With this technology, I want to enable researchers and clinicians to study the detailed structure and function of individual neurons and their interactions in the living human eye with microscopic 3-D tomography. This revolutionary approach may provide new insights into human physiology and aid in the diagnosis and treatment of ophthalmic and neurological conditions. With a strong background in high-performance computational imaging methods, their application to retinal imaging, and experience in both industry and academia, I am uniquely qualified for this groundbreaking research.

Keywords: optical imaging,retina imaging,optical coherence tomography,microscopy,structured illumination,neurology,ophthalmology
Nanoparticles in Situ Surface Growth for Direct Fabrication of Functional Patterned Nanomaterials (NANOGROWDIRECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2125000.0
EU funding (EUR): 2125000.0
Participants: 1
Project status: SIGNED

Due to their unique physicochemical properties, nanopatterned surfaces can contribute to important technological innovations for efficient optical and communication devices, long-lasting batteries, and ultrasensitive diagnostic devices. Bottom-up synthesis enable to construct nanomaterials atom-by-atom from precursors using synthetic chemistry, usually producing colloidal nanoparticle suspensions that are later assembled on a surface. Alternatively, the fabrication process can be greatly simplified by instead applying bottom-up growth directly on a substrate. However, these “in situ” growth routes remain largely unexplored and poorly understood. To address this knowledge gap and improve versatility and quality of this class of approaches, I propose to use an unconventional methodology called “chemical contrast in situ growth” or CC-iSG, where precise nanometric chemical contrast drives nanostructure formation at pre-determined sites. With NANOGROWDIRECT, I will develop a foundational understanding of CC-iSG through the interrogation of fundamental synthetic aspects, and maximize its potential for achieving exemplary control over nanoscale properties of nanosurfaces and metamaterials. I will interrogate the effect of the identity, concentration, and delivery of various reactants to the pre-determined reaction sites, with focus on chemical control (Objective 1) and fluid dynamic control (Objective 2). I will also test the use non-chemical external factors, such as electromagnetic fields (Objective 3), and electrochemical potentials (Objective 4). In the short term, CC-iSG will open up unexplored directions for engineering physicochemical properties of patterned nanosurfaces, combining wet-chemistry and external stimuli. Consequently in the long term, the far-reaching impacts of NANOGROWDIRECT will go beyond the field of nanochemistry, and yield breakthroughs in (photo/electro)catalysis, energy production and storage, medicine, and communications.

Keywords: in situ growth,chemical contrast,heterogeneous nucleation,colloidal chemistry,soft lithography,microfluidics,light matter interactions,electrochemistry,metasurfaces
Plant-Based Proteins and Antioxidants in Hybrid Meat for Dysphagia (HyPAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-22
End date: 2027-09-21
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Dysphagia is a common condition among the elderly, characterized by swallowing difficulties, that leads to malnutrition and increased mortality. Addressing dysphagia is becoming increasingly critical, especially as the global aging population is expected to reach 1.5 billion by 2050. The HyPAD project addresses this issue by developing innovative hybrid meat products tailored for dysphagia patients. These products will integrate plant-based proteins and bioactive compounds with advanced 3D food printing technology to offer improved nutritional value, safer textures, and appealing sensory qualities, significantly enhancing the quality of life for those affected. Currently, dysphagia-friendly foods often lack nutritional balance and are unappealing, leading to poor patient acceptance. HyPAD aims to overcome these limitations by exploring sustainable sources of plant proteins and bioactive compounds, optimizing hybrid meat formulations, and employing 3D printing to achieve desired textural properties. Specific aims include developing and rigorously testing these formulations, with planned short visits to industry partners for refining the products. The comprehensive plan integrates various disciplines, including phytochemistry, nutrition, and food sciences. This interdisciplinary approach ensures that the products developed are not only effective but also environmentally sustainable, aligning with global efforts to reduce the environmental footprint of food production. Through this project, the fellow will gain expertise in cutting-edge food technology and sustainable practices, enhancing his career prospects in both academia and industry. HyPAD not only advances scientific knowledge in dysphagia management but also sets new standards for sustainability in food production, creating new market opportunities in geriatric nutrition and functional foods.

Keywords: hybrid meat,dysphagia,polyphenols,plant proteins,3d printing
The African Origins of Western Canon Law. An Investigation into the Corpus canonum Africano-Romanum (AFRICANON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

In the proposed project, I aim to prepare a comprehensive study of the most important North African collection of canon law, the Late Antique Corpus canonum Africano-Romanum (CCAR), which is also the oldest known canonical collection of the Western Church. This collection is of fundamental importance, because 1) it had greatly impacted the development of occidental canon law on a textual level (to name but a few collections: Hispana, Dionysio-Hadriana, the Hispana Gallica Augustodunensis and the Decretum Gratiani) 2) it had a long-lasting impact on the perception of Africa in Medieval Western Europe, because its textual material was extremely widely disseminated and used across the continent. Canon law texts are not only sources of legal history, but they can be evaluated as sources of historiography and social history as well; the CCAR is a prime example for how texts have been selected, reshaped and adapted by later generations. These observations also lead to several questions, which shall be addressed: To what extent is the CCAR transmitted in mss. alongside texts of African church fathers? What documents have been revised when copying the CCAR, which African texts have been omitted, rearranged, annotated? Has the legitimacy and authenticity of the African canons been contested or doubted in later periods? What role did Africa play in the “imagined landscape” of Western Christianity and Latin canon law? As ties between Western Europe and North Africa had become severed, did it follow that the now essentially decontextualized African material could be reinterpreted or even manipulated for one’s own purposes? In other words: in what ways does the textual shape of the CCAR derive from later scribes and compilers making liberal use of the past? On the basis of the CCAR, I will set out to to trace and evaluate the reception of selected North African canons both within the broader context of Western canon law and in the context of societal processes defined by it.

Keywords: legal history,canon law,ecclesiastical law,canonical collections,church history,medieval manuscripts
Flotus is a ground breaking solution for floating photovoltaics that combines a robust naval engineering design with a sun tracking system in order to maximise the energy production and reliability. (FLOTUS TRACKERS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

FLOTUS aims to advance the energy transition by integrating utility-scale solar technology into Floating Photovoltaics (FPV). To meet the UN's and EU Green Deal decarbonization objectives and limit global warming to 2ºC in 2050, compared to pre-industrial levels, a massive deployment of renewable energy is essential. Tackling this challenge will involve large investments in grid network and energy storage while competing with other land uses. Additionally, climate change is expected to exacerbate water scarcity for hydroelectric generation, irrigation, and consumption in various regions and periods. Floating photovoltaics can address challenges in both renewable energy and water management by utilizing the space and grid infrastructure of hydropower dams -and off-grid reservoirs- thereby preserving water and enhacing water quality control. Leveraging a decade of experience in the design and manufacture of ground-mounting solar trackers, FLOTUS is the response of a group of intrapreneurs from a Spanish solar energy corporation to a high-growth niche within Photovoltaics by offering advanced energy generation hardware and software. This is bound to contribute to unlocking the potential of FPV, which in the case of inland waters alone is estimated at 3,000 GW worldwide. The most innovative aspects that FLOTUS bring into FPV is the East-West tracking system, a feature typically found in ground-mounted trackers whereas dominant floating solutions -mostly supplied by Chinese companies- are fix-tilt. This system increases energy yields per installed capacity, making it ideal for utility-scale plants in latitudes covering Southern Europe, Northern Africa, Mexico and most US, Brazil, Chile and Colombia. Additional benefits of FLOTUS include an enviromental friendly layout that minimizes bottom shading, as well as a durable naval design suitable for harshest water conditions. FLOTUS will be launched as a startup of ex-Soltec engineers.

Keywords: floating pv,renewable energy,fpv,photovoltaics,water,reservoirs
Humanities Rock! Research: Shaping the Future of Humanity (HUMANITIES ROCK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Slovenia
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-05-01
End date: 2025-12-31
Duration (months): 20.0
Total project cost (EUR): 299723.13
EU funding (EUR): 299723.13
Participants: 1
Project status: SIGNED

The HUMANITIES ROCK! ERN 2024-2025 builds upon the successes of the 2018-2019, 2020, and 2022-2023 editions, all organized by the University of Ljubljana. Our core mission remains consistent: to facilitate closer interaction between research and the general public. Our overarching objectives persist: to enhance understanding of research and innovation activities, to bolster public recognition of science and research education, to underscore the researcher's role in society and the economy, to showcase the tangible impact of research on daily life, and to inspire young individuals to consider research and scientific careers. In an era where science denialism and skepticism towards scientists are prevalent, often attributed to academia's hesitance to engage with the broader public, our 2024-2025 edition unites STEM and SSH disciplines with the explicit goal of bringing research and researchers to the forefront. Our aim is to establish direct channels of communication with the general public, reinstating credibility and trust in research, innovation, and those who drive these efforts, while promoting public recognition of science and research education. The 2024-2025 edition focuses on the expansive theme "RESEARCH: SHAPING THE FUTURE OF HUMANITY." This theme underscores research's pivotal role in shaping society's future and generating sustainable impact. It aspires to mobilize citizens, encouraging them to embrace innovative solutions and approaches, while fostering greater societal acceptance and engagement with science and research. Our planned activities are particularly geared towards children, young individuals, and those who may typically be less inclined towards science. These activities encompass shows, competitions, exhibitions, lab visits, workshops, discussions, hands-on experiments, EU corners, open days, and live interactions with scientists. These events will take place in public venues and research institutions, which will open their doors to visitors.

Keywords: researchers night,science,humanities,open science,research career,public at large,friday night,science communication,eu corner,promotion of science,inclusive society,rri
Nature-Based Solutions for Demonstrating Climate-Resilient Critical Infrastructure (NATURE-DEMO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Czechia,North Macedonia,Netherlands,Norway,Romania,Slovakia,Austria,Switzerland,United Kingdom,Germany,Greece,Spain,Slovenia
Call: Testing and demonstrating transformative solutions to protect critical infrastructure from climate change, mainstreaming nature based solutions. (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 8162693.94
EU funding (EUR): 7761769.38
Participants: 23
Project status: SIGNED

As climate disruptions become more frequent and intense, the resilience of Europe's infrastructure is crucial as it supports economic flows, human well-being, and social stability throughout the continent. However, this challenge provides a historic opportunity to revolutionise infrastructure by integrating it with nature. Hence, NATURE-DEMO creates, validates, and spreads nature-based solutions (NbS) for protecting infrastructure against climate threats. It covers critical sectors (e.g. transport and energy) and engages an alliance of infrastructure owners, scientists from industry and academia, and public authorities. NATURE-DEMO aims to shift decision management from reactive measures to proactively designing holistic systems that are resilient by design through four actions: Create, Validate, Scale, and Sustain. NATURE-DEMO will Create an advanced digital decision support platform that will integrate climate projections, asset exposure, NbS catalogue portfolios, and advanced simulations to optimise the efficiency of selected NbS implementations to enhance resilience and deliver co-benefits. NATURE-DEMO will Validate its methodology with real-world demonstrations of optimised NbS across 5 sites in the Alpine Biogeographic region. Successful NbS will then be Scaled as replicators in +4 other sites in the Alpine and other Biogeographic regions. NATURE-DEMO will Sustain its solutions beyond its timeframe by focusing on exploitation pathways that include tailored guidelines that disseminate NbS knowledge across infrastructure professions, a Task-Force available to provide technical expertise, and a financial observatory for NbS funds. By pioneering a scalable, digitally-enabled and validated framework for implementing NbS, NATURE-DEMO will help realise the EU’s vision for a climate-resilient and sustainable economy optimised for the realities and demands of the 21st century - a vision for posterity.
mRNA localization and spatial heterogeneity of translation: Deciphering the code within mRNP composition (mRNPcode)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

mRNAs are packed with RNA binding proteins (RBPs) to assemble the messenger ribonucleoprotein particles (mRNPs). Proper mRNP biogenesis, export, localization, translation, and decay are central for gene expression regulation. Each step requires specific RBPs mediating transcript interactions with the cellular machinery. So far, hundreds of RBPs have been identified begging the question of mRNP assembly diversity. While canonical RBPs are associated with all transcripts, some may be accessory, concurrent, and specific for subclasses of mRNAs. What finetunes mRNP compositions is not clear and understanding how specific mRNP compositions control mRNA fate is a major challenge for RNA biology. mRNA localization and regulated translation are believed to be mechanisms to delimit gene expression to cellular sub-compartments ensuring that proteins are synthesized where they complete their functions. Furthermore, some mRNAs display heterogeneous translation efficiencies depending on their localization in cells. mRNA localization and translation heterogeneity appear to be highly dynamic and can be fine-tuned upon cell differentiation, or during stress. These phenomena seem crucial during development, particularly for large syncytial cells such as Drosophila embryos but their prevalence and functions are not understood. We hypothesize that mRNA localization and translation kinetics are encoded by the different combinations of RBPs assembling the mRNPs. We aim to decipher the link between mRNP composition, localization, and translation heterogeneity for key mRNAs controlling embryonic patterning in Drosophila embryos. The mRNPcode project will combine mRNP capture, proteomic, and cutting-edge microscopy for single particle tracking and translation imaging to build a dynamic picture of mRNP composition, localization, and translation. The project tackles long-lasting questions beyond the Drosophila developmental field by exploring mRNP assembly and its imprinting on mRNA fates.

Keywords: mrna,messenger ribonucleoprotein particles mrnps,rna binding protein,mrna localization,translation,localized translation,translation kinetic,proteomic,mrna tracking,translation imaging