Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A minimal Cys-cyclobutene non-canonical amino acid for bioorthogonal imaging of proteins in live cells (MinBioTag)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Insight into dynamic processes such as uptake and intracellular trafficking and signalling of small molecules and proteins in cells is key in basic biology and drug development. The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity. So, in this application we propose to achieve site-selective protein labelling by the introduction of a non-canonical Cys-cyclobutene aminoacid and a very fast alkene chemoselective ligation reaction. The small size of the proposed alkene-tagged aminoacid should not interfere with the protein structure, function, activity or localisation in contrast with other fluorescent tags such as the use of fusion proteins as GFP. This project aims at 1) developing a new photo triggered [2+2] cycloaddition bioorthogonal ligation between two alkene containing partners and to apply the already established IEDDA reaction between tetrazines and dienophiles. While the use of light as a trigger offers the possibility for an improved spatial and temporal resolution, the use of tetrazine fluorogenic probes allows for ‘turn-on’ fluorescence on their rapid reaction with dienophiles 2) use these optimized reaction to study apoptosis in cells and tissues by introducing the proposed Cys-cyclobutene non-canonical amino acid into C2A Domain of Synaptotagmin-I followed by the ligation reaction ex vivo and in vivo
A Collaboration Ecosystem enabling EU Creative SMEs to exchange multi-media content and create multi-plot, interactive Apps for Children, curated according to Reader ability and educational value. (Q-Tales)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Ireland,Italy,Poland,Greece,Greece,United Kingdom,United Kingdom
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 1273526.6
EU funding (EUR): 986193.0
Participants: 9
Project status: CLOSED

“Q-Tales” is a Collaboration Ecosystem, specifically designed to serve the needs of the European Children e-book industry, where European Creative SMEs, Experts and Parents, co-create new or transform existing Children Literature into high quality e-books & Apps using innovative ICT solutions provided by European ICT SMEs along with a Curation Framework provided by European Academic experts in the field of Pedagogy, Children Psychology and evolutionary Psychology. The specific objectives of the project are summarized below: • Objective 1: Build the Q-Tales Collaboration Platform and respective ecosystem, including Gamification Aspects, where European self-publishers, authors, illustrators, voice actors, animators and other related SMEs & professionals will find & submit industry news, communicate, offer & receive services and collaborate. • Objective 2: Develop the Q-Tales Authoring Tool, featuring an easy-to-use interface with powerful and sophisticated authoring features which will be used to create the Q-Tales e-books and apps, incorporating the Q-Tales Ontology and utilizing gamification techniques. • Objective 3: Launch the Q-Tales Store where the authored e-books and apps will be offered worldwide. • Objective 4: Define the Technical and Pedagogical Q-Tales Curation Frameworks, in order to ensure that every single item sold is, technically perfect and better connected with current academic developments in the fields of child / evolutionary psychology while offering a scent of “Europeanness”, whilst incorporating nation- and country-specific literacy cultural and linguistic elements. • Objective 5: Develop a new breed of in-app analytics services. • Objective 6: Identify & Connect with established European Children Literature Content Providers and Sources. • Objective 7: Establish Q-Tales as a Brand Name with European Publishing Industry. • Objective 8: Introduce the Q-Tales Awards as an annual creativity competition.

Keywords: curation,gamification,ebook,e book,book,children,literature,app store,content curation,disabled,special needs,impaired,vision,hearing,disabilities,syndrome
Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation (EXODUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-05-31
Duration (months): 69.0
Total project cost (EUR): 1998063.0
EU funding (EUR): 1998063.0
Participants: 1
Project status: CLOSED

The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in distant organs like the central nervous system (CNS). Here, we raise the hypothesis that immune cells must be activated at epithelial surfaces and then physically migrate to distant organs in order to induce autoimmunity. Furthermore, we propose that the “state of activation” of (either lymphoid or myeloid) immune cells can be interrogated by IL-6 production since IL-6 deficiency confers resistance to virtually any organ specific autoimmune disease and we have contributed fundamentally in defining the role of IL-6 for the generation of Th17 cells that are highly associated with autoimmune tissue inflammation. In EXODUS, we will develop ground-breaking next generation reporter tools in order to test these hypotheses. A split Cre recombinase protein, which dimerizes and is activated by blue light, will be used to genetically label cells (and their progeny) in a topologically defined manner (“compartment reporter”). Furthermore, we have developed a novel type of Cre-inducible in vivo IL-6 reporter (“activation reporter”). The combination of these tools will enable us to trace the anatomical compartment of activation of immune cells without limitations in lag time. Thus, site specific photogenetic co-induction of a fluorescence and IL-6 reporter will be used to probe peripheral sites for their potency to licence immune cells to travel to the CNS (Forward). Vice versa, labeling of cells in the CNS (through a thinned skull window) will allow for studying immune cell exodus from the CNS in homeostasis and during inflammation (Reverse).

Keywords: immune cell trafficking,cytokines
INTENSE: particle physics experiments at the intensity frontier. A cooperative Europe - United States effort. (INTENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Italy,Italy,Switzerland,Switzerland,Switzerland,France,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 2614974.74
EU funding (EUR): 2614974.74
Participants: 11
Project status: SIGNED

INTENSE is a new European training network between universities, research centres and industries that will carry out an interdisciplinary research and training program for a cohort of 11 fellows. INTENSE promotes the collaboration among European and US researchers involved in the most important particle physics research projects at the high intensity frontier. The observation of neutrino oscillations established a picture consistent with the mixing of three neutrino flavours with three mass eigenstates and small mass differences. Experimental anomalies point to the presence of sterile neutrino states partecipating in the mixing and not coupling to fermions. Lepton mixings and massive neutrinos offer a gateway to deviations from the Standard Model in the lepton sector including Charged Lepton Flavour Violation (CLFV). The FNAL Short-Baseline Neutrino (SBN) program based on three almost identical liquid argon Time Project Chambers located along the Booster Neutrino Beam offers a compelling opportunity to resolve the anomalies and perform the most sensitive search of sterile neutrinos at the eV mass scale through appearance and disappearance oscillation searches. MicroBooNE, SBND, and Icarus will search for the oscillation signal by comparing the neutrino event spectra measured at different distances from the source. The FNAL SBN program and the CERN ProtoDUNE are a major step towards the global effort in realising the Deep Underground Neutrino Experiment (DUNE). Mu2e at FNAL will improve the sensitivity on the search for the CLFV neutrinoless, coherent conversion of muons into electrons in the field of a nucleus by for orders of magnitude. MEG-II and Mu3e at PSI will improve the sensitivity on other CLFV muon decays. INTENSE researchers have provided leading contributions and will take leading roles in detectors commissioning, data taking and analysis. These endeavours foster the development of cutting-edge technologies with spin-offs outside particle physics.

Keywords: flavour physics,neutrino oscillations,charged lepton flavour violation,liquid argon time projection chamber,crystal calorimeter,photo multipliers,muon beam line,machine learning,data analysis
Networking for Excellence in Solar Thermal Energy Research (NESTER)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Cyprus,France
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1060797.5
EU funding (EUR): 1060797.5
Participants: 5
Project status: CLOSED

The NESTER proposal aims in upgrading the scientific and innovation performance of the Cyprus Institute (CyI) in the field of Solar-Thermal Energy (STE). The upgrade will be achieved by embedding the Institute’s activities in a network of excellence, which will provide access to the latest know-how and facilities, train CyI’s scientific and technical personnel and link it with the European Industry. The substantial investments made/planned by CyI in infrastructure and personnel will thus become more efficient and competitive allowing claim to international excellence. The geopolitical placement of Cyprus offers excellent opportunities for cultivating a research and innovation niche in Solar Technologies. At the same time the remoteness of the corresponding centres of Excellence of EU is a major impediment. The NESTER proposal strives to enhance the advantages and ameliorate the disadvantages of this geographical placement. The NESTER network comprises of three leading institutions in the field of solar energy research (CIEMAT, ENEA, PROMES/CNRS and RWTH – Aachen). They possess a formidable know how in this field and operate some of the most important facilities, worldwide. The resulting enhanced capabilities and status of CyI would in turn reflect positively on developing the knowledge economy of Cyprus. It will also enhance the positioning of Cyprus as an important player in applied scientific research at the interface of the European and Middle East/North Africa regions. A number of activities are proposed in a detailed program which includes training and knowhow transfer, seminars and networking events with European and EMME partners, summer school activities, and public outreach and awareness and networking events. It is designed to ensure sustainability, evolution and continuation of the activities including the cooperation among the partners well beyond the expiration of the three-year funding period.

Keywords: solar energy,solar thermal energy,concentrated solar power,renewable energy,energy storage
Hacking your way to IT expertise: What digital societies can (and need to) learn from informal learning in hackerspaces (HACKIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

HACKIT will advance our understanding of how individuals acquire information technology (IT) expertise in informal learning environments. IT skills, such as coding, are crucial for economic growth in the European Union (EU). But it is estimated that there will be a shortage of 900,000 IT professionals by 2020. Women are underrepresented in IT professions in all EU countries. These issues impede the competitiveness of the European IT sector and prompt questions about its inclusiveness. In order to develop effective, inclusive educational policies and initiatives addressing this IT skills shortage and gender gap, we need answers to pressing questions: Why, where, how, and by whom are IT skills trained? The relevance of informal learning for IT professions has been emphasised in this context. Yet, empirical, particularly observational research on IT learning in informal environments is largely missing. My project will tackle this research gap by conducting a digital ethnography of ‘hackerspaces’ in the United Kingdom. Hackerspaces are key examples for informal IT learning environments: they are physical places where community members engage in activities involving coding and electronics. Misleadingly, ‘hacking’ is predominantly associated with illegal acts, but hackerspace members actually pursue legal, innovative IT practices. By ethnographically approaching hackerspaces, I will realise three main objectives: First, with participant observations, I will investigate how individuals acquire and cultivate IT skills in hackerspaces. Second, through interviews, I will examine which factors (de-)motivate members’ IT learning. Third, I will detail how my study can inform educational policies and initiatives fostering IT expertise in Europe. Overall, while I will investigate how hackerspaces function as facilitative environments, I will likewise examine factors of in- and exclusion relevant to informal IT learning, especially regarding minority groups.

Keywords: information technology it,informal learning,hackerspaces,digital ethnography
Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis (ChondUb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 171792.6
EU funding (EUR): 171792.6
Participants: 2
Project status: CLOSED

Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age. The pathogenesis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been elucidated. Ubiquitination regulates most signalling pathways and cellular processes. Previously, I have shown that ubiquitination plays a role in OA development. Here I aim to identify and characterise WWP2 substrates using a combination of novel techniques. In addition, I will investigate the role of WWP2 and its substrates in cartilage biology with the goal to uncover molecular targets for OA treatment and other WWP2-related diseases. The project is aligned with the “Health, Demographic Change and Well-Being” and “Understanding disease” challenges of Horizon2020. The work will be performed under supervision of Dr Weissman, Chief of the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute (US) and at “EULAR Centre of Excellence” at Newcastle University (UK) under supervision of Prof Young. Dr Weissman has an excellent track record in ubiquitin ligases biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA. Therefore, both groups are highly complementary for this project and envisage future collaborations arising from this fellowship. During this multidisciplinary project I will acquire new knowledge and will reinforce my research skills by learning novel techniques. It is a great opportunity to conduct a creative and independent research facilitating achievement of my main career goal to become an independent research group leader.

Keywords: chondrocyte,osteoarthritis,ubiquitination
Power and heating sector coupling through district heating networks for sustainable future (COUPLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-14
End date: 2024-03-13
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Urgent decarbonisation of all energy-related sectors is vital in order to reduce climate change impact and secure sustainable growth. To achieve to this goal, increase of renewable energy sources, especially wind and solar, is crucial. Due to their intermittent nature, they are challenging to integrate in the power sector. One of the most recognized solutions is so called sector coupling – connection of various energy sector to achieve balancing of intermittent electricity production from renewable energy sources. District heating, in combination with heat pumps, is more than suitable technology for power and heating sector coupling. In order to secure the role of district heating in future energy systems with high share of variable renewable energy source, the impact of different boundary conditions such as district heating supply temperature, heat pump source temperature and availability, has to be studied. This project will provide systematic analysis of the impact of DH network parameters on the successful integration of variable RES in the power system through sector coupling and utilisation of building thermal mass as a thermal storage option. This will be carried out by developing numerical model capable of assessing opportunities of ancillary services and demand response capabilities enabled by heat pumps in future power markets combined with thermal inertia of buildings’ as the thermal storage. Then, strategies for a large-scale integration of heat pump technologies, in the power markets with a great share of variable renewable energy sources, will be developed. The project outputs will facilitate positioning district heating systems and heat pump technologies as the key component of future energy systems thus, enabling a greater share of RES in the final energy consumption, higher energy efficiency. Consequently, this will result in lower greenhouse gasses (GHG) emissions thus supporting EU energy and climate long-term goals and policies.

Keywords: district heating,heat pumps,thermal storage,optimization,sector coupling
RNA virus attenuation by altering mutational robustness (1toStopVax)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

RNA viruses have extreme mutation frequencies. When a RNA virus replicates, nucleotide mutations are generated resulting in a population of variants. This genetic diversity creates a cloud of mutations that are potentially beneficial to viral survival, but the majority of mutations are detrimental to the virus. By increasing the mutation rate of a RNA virus, viral fitness is reduced because it generates more errors, and attenuates the virus during in vivo infection. Another feature that affects RNA virus fitness is mutational robustness. Mutational robustness is the ability to buffer the negative effects of mutation. The attenuation of RNA viruses for vaccine production faces problems of genetic instability and reversion to a pathogenic phenotype. The conventional method for attenuation is mostly empirical and specific to the particular RNA virus species. Hence, it cannot be universally applied to a variety of virus types. We've developed a non-empirical, rational means of attenuating RNA viruses, targeting mutational robustness as modifiable trait. We demonstrate that mutational robustness of RNA viruses can be modified without changing a virus' physical and biological properties for vaccine production; yet the virus is attenuated as it becomes victim of its naturally high mutation rate. Specifically, the genome of RNA viruses are modified so that a larger proportion of mutations become lethal Stop mutations. Our technology places the virus one step away from these Stop mutations (1-to-Stop). We succeeded in attenuating two RNA viruses from very different viral families, confirming the broad applicability of this approach. These viruses were attenuated in vivo, generated high levels of neutralizing antibody and protected mice from lethal challenge infection. The proposal now seeks to complete proof of concept studies and develop commercialization strategies to scale up this new technology to preclinical testing with industrial partners.

Keywords: vaccines,rna viruses,live attenuated virus