Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LIQUID BIOFERTILIZER FORMULATED WITH PLANT GROWTH PROMOTING RHIZOBACTERIA (Bulhnova)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The rising need for food safety, in response to the rising global population calls for new technologies for higher and healthier crop yields. Fertilizers are a vital agricultural additive, essential to the security of the world’s food supply. While chemical fertilizers have their place increasing plant nutrients, they also come with several harmful effects (ground water contamination, increased air pollution, and mineral depletion). Bio-fertilizers are a viable option for an efficient and rational use of agricultural resources with low adverse environmental impacts. However, bio-fertilizers also have several limitations that hinder their potential for greater impact in the agricultural industry (shorter shelf life, insufficient macronutrients, higher application volumes, nutrient variability, crop specificity and high handling and application costs. Probelte has developed Bulhnova, an appropriate response to the limitations of current bio-fertilisers. Bulhnova is an innovative Nitrogen fixing Bio-Fertilizer, formulated from a group of bacteria that colonise roots or rhizosphere soil. The particular bacteria contained in Bulhnova includes Azospirillum brasilense and Pantoea dispersa, both in amounts superior to 1x108 Colony Forming Units (CFU)/ml. Azospirillum brasilense is responsible for the atmospheric nitrogen fixation, whilst Pantoea dispersa is responsible for the solubilisation of phosphates and potassium. Bulhnova provides an integrated Bio-fertilizer that combines Nitrogen, Phosphorus and Potassium supply under a single product through the successful merging of our two strains of bacteria. The benefits of using Bulhnova include multi-nutritional capability, reduced dosage amounts (only 20L/Ha), enhanced crop output (by 40%), reduced salinization and ground nitrate content by up to 100%, drastic reduction of carbon footprint compared to equivalent nitrogen fertilizers and lower handling, storage and application costs.

Keywords: biofertilizer,environmental protection,agrobiotechnology,horticulture,viticulture,agronomy,husbandry
Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases (JPsustaiND)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Spain,Croatia,Romania,Sweden,Slovakia,France,Netherlands,Denmark,Portugal,United Kingdom
Call: Towards sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases (H2020-HCO-2015, 2015)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 2043283.75
EU funding (EUR): 2043283.75
Participants: 19
Project status: CLOSED

The overall aim of JPsustaiND is to support the development and extension of the capacities of the EU Joint Programming Initiative on Neurodegenerative Diseases, in particular Alzheimer's (JPND). Since 2009 JPND has been operating on a very light management structure based on a simple Terms of Reference. Through this JPND has been able to set a common Strategic Research Agenda, and to deliver its first implementation plan that has allowed among other achievements, the mobilisation of approximately €100 million of additional funding between 2011 and 2015 to support transnational research programs. While progress has been pleasing to date, the implementation of JPND must now be scaled-up to further catalyse Member State commitments, and to formalize synergies between members and various partners. The immediate challenge therefore for JPND is to secure its long-term sustainability by Member States, to mobilize those which are not yet participating, and to increase its impact at the national level and globally. JPsustaiND thus aims at creating the dedicated structure responsible for long-term JPND management and implementation, and extension of JPND membership to EU Member States and other countries and initiatives not yet participating. To achieve this goal, the JPsustaiND partners, with the support of the JPND Management Board, will implement the following six workpackages: Coordination and Management; Long Term Sustainability; Capacity Extension; Alignment and Outreach; Communication and Advocacy; and Monitoring, Evaluation and Impact Assessment. JPsustaiND will implement a stronger global dimension of the JPND, and will avoid duplication of research and infrastructure investment at the national level. By supporting further coordination and integration of national research and innovation programmes with the JPND research strategy, in coherence with Horizon 2020 objectives, JPsustaiND is thus creating a dedicated European Research Area for neurodegenerative diseases.

Keywords: jpnd,sustainability,joint programming,neurodegenerative diseases,alzheimer,mapping,alignment of research agendas,extension of capacities,dedicated structure
Uncovering Enteric GLIA-MACrophage communication in the intestinal homeostasis and inflammation (GLIAMAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Uncovering Enteric GLIA-MACrophage communication in the intestinal homeostasis and inflammation. The enteric nervous system (ENS) is a network of neurons and enteric glial cells (EGCs) organized in ganglia essential to control gastrointestinal physiology. Although EGCs have historically been described as supporting cells for enteric neurons, recent data from my previous work and from my host group demonstrated that enteric glia is “communicating” with innate immune cells via the secretion of immune-active molecules. Interestingly, alterations in the morphology and function of EGCs have been reported in patients affected by chronic intestinal inflammation such as inflammatory bowel disease (IBD). Thus, I hypothesise that factors released by enteric GLIA may directly modulate MACrophage phenotype and function in the gut, making EGC a novel overlooked player in the pathophysiology of IBD. In the first part of GLIAMAC, the molecules and the molecular mechanisms involved in the enteric glia-macrophage crosstalk will be screened in vitro using co-culture experiments and assessed in vivo using novel EGC-specific mouse models of intestinal inflammation. Finally, I aim to translate our findings to the clinical setting using tissue samples from IBD patients. To this end, the immunomodulatory properties of EGCs isolated from healthy individuals and IBD patients will be compared using cellular, genomic and proteomic system-wide approaches. Identification of new molecules and pathways involved in enteric glia-immune cell crosstalk will represent a major breakthrough in elucidating the pathogenesis of intestinal immune-mediated diseases. Thus, GLIAMAC will potentially give rise to a new class of molecules to treat and favour remission in patients affected by IBD.

Keywords: inflammatory bowel disease,mucosal immunity,enteric nervous system,macrophages,enteric glial cells
Imaging, characterizing and targeting metastatic niches in melanoma (METALERT-STOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 2497945.0
EU funding (EUR): 2497945.0
Participants: 1
Project status: SIGNED

Melanomas are the only tumors where lesions barely over one millimeter in depth can be at risk for metastasis. An increasing number of (epi)genetic alterations and mechanisms of immune evasion have been identified in this disease. Nevertheless, no molecular biomarker has been approved as a bona fide prognostic indicator. Progress in this field has been hampered by the paucity of models to visualize premetastatic niches in vivo, and monitor relapse after surgery. We have overcome these limitations by generating reporter mouse strains to “illuminate” premetastatic niches. Specifically, our “MetAlert” mice were designed for whole-body imaging of the aberrant expansion of the lymphatic vasculature, an early event that precedes metastasis. MetAlert, together with functional studies in human cells and histopathological validation in clinical biopsies, revealed the growth factor MIDKINE as a new melanoma-secreted prometastatic driver. We have now discovered roles of MDK as an immune suppressor, and identified a MDK-associated transcriptional profile that separates patients with a distinct expression of alarmins and bacterial response factors. Proteomic analyses revealed a set of additional factors secreted by aggressive melanoma cells, but their specific contribution to premetastatic niches is unclear. Here we will exploit our MetAlert and novel imaging reporters we have generated for a comprehensive spatio-temporal and functional analysis of premetastatic niches in vivo (including and beyond MDK). We will define how melanomas act “at a distance” before metastasis (Aim 1), and evade the immune system at different anatomical sites (Aim 2). Aim 3 will dissect the impact of the microenvironment, particularly via alarmins. Aim 4 will pursue the therapeutic targeting of metastatic niches (pre and post-surgery) with immunomodulators we discovered (and have led to clinical trials), and by targeting vulnerabilities that we found distinguish melanoma from other diseases.

Keywords: melanoma,immunotherapy,immuno tolerance,tumor biomarkers,metastasis
A platform for rapidly mapping the molecular and systemic dynamics of aging (SYSAGING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499981.0
EU funding (EUR): 1499981.0
Participants: 1
Project status: SIGNED

A central goal of molecular medicine is to understand how genetics, diet, and environment interact to determine health. However, most complex diseases arise from slow, stochastic changes involving large numbers of genes, making it difficult to systematically develop preventative therapies. To study the early and mid-life origins of late-life diseases, we need new methods capable of measuring the high-dimensional dynamics of physiologic change during aging. C. elegans is a small, fast-aging animal and a powerful model for asking fundamental questions about the conserved molecular origins of complex diseases. However, it is not yet feasible to systematically collect molecular and phenotypic time-series at the precision and scale needed to build quantitative dynamic models of aging. Recently, I developed an automated microscopy and image processing technology that allows life-long observation of large populations. In this proposal, we develop this prototype into an integrative platform combining transcriptomic profiling, in vivo biosensors, and new imaging technology. Collecting data at multiple spatial scales—molecules, cells, individuals, and populations—we can map the causal steps through which slow, stochastic molecular changes drive increases in disease risk. We will then apply this method at scale to characterize all known lifespan-altering interventions in C. elegans, including many being explored for clinical application. Combining molecular genetics with theoretic approaches, we will build quantitative models of how complex diseases emerge from slow molecular-level changes, and make methodological progress toward rapid characterization of the determinants of age-associated diseases. This work will help isolate the physiologic changes whose disruption delays aging and reduces disease risk, including new targets for preventative therapies.

Keywords: ageing,health,lifespan,age related diseases,interventions in ageing,fundamental mechanisms of ageing,dynamical systems,stochastic processes,causality,statistical inference,complexity theory,microscopy,fluorescent imaging,longitudinal imaging,genetics,molecular genetics,transcriptomics,single cell sequencing,caenorhabditis elegans,nematodes
Cosmology Beyond Homogeneity and Isotropy (BEHOMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 137604.96
EU funding (EUR): 137604.96
Participants: 1
Project status: CLOSED

I will carry out a research program to understand how cosmological structures evolve and how the corresponding observables are modified in an inhomogeneous universe. This project will place the field of inhomogeneous cosmologies into the era of precision cosmology. Indeed, it is very difficult to obtain the evolution of structures when the background is inhomogeneous and it has not been possible to fully constrain inhomogeneous cosmologies because of this lack of understanding. As I will argue, the most promising approach is via Numerical Cosmology. This justifies why this fellowship will be carried out at the Astronomical Observatory of Trieste under the supervision of Stefano Borgani, one of the world experts in Numerical Cosmology. The scientific motivation behind this effort is that cosmology is undergoing a crisis, facing, at the same time, unexplained components (dark matter and dark energy) and a >4sigma tension between local and global determinations of the Hubble constant. It is then imperative to test basic assumptions in cosmology, such as large-scale homogeneity and isotropy. These are indeed among the objectives of many major space- and earth-based international collaborations (Euclid, LSST, SKA), which will produce detailed maps of a good fraction of the observable universe. Only after carrying out these tests can one hope to discover the nature of dark matter and dark energy.

Keywords: inhomogeneous cosmological models,numerical simulations,cosmological principle,copernican principle
The Role of Dopamine in the Regulation of Sleep and Circadian Rhythms (CircaDopamine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinson’s disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.

Keywords: dopamine,circadian rhythms,sleep regulation
European Space Robot Control Operating System (ESROCOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Belgium,Finland,Belgium,France,France,France,United Kingdom,Portugal
Call: SRC - Space Robotics Technologies (H2020-COMPET-2016, 2016)
Start date: 2016-11-01
End date: 2019-01-31
Duration (months): 27.0
Total project cost (EUR): 3500053.75
EU funding (EUR): 3499995.75
Participants: 12
Project status: CLOSED

The ESROCOS activity is devoted to the design of a Robot Control Operating Software (RCOS) that can provide adequate features and performance with space-grade Reliability, Availability, Maintainability and Safety (RAMS) properties. The goal of the ESROCOS proposal is to provide an open source framework which can assist in the generation of flight software for space robots. By providing an open standard which can be used by research labs and industry, it is expected that the elevation of TRL levels can be made more efficient, and vendor lock-in through proprietary environments can be reduced. Current state-of-the-art robotic frameworks are already addressing some of these key aspects, but mostly fail to deliver the degree of quality expected in the space environment. Terrestrial RCOS developed by industrial robot companies (e.g. VxWorks, PikeOS) are not usable for space robotics because their Intellectual Property Rights (IPR) enforce the vendor’s dependency on space development. Other open-source frameworks do not have sufficient RAMS properties for its use in space missions. The ESROCOS objectives are to: 1. Develop a Space-oriented RCOS including space-grade RAMS attributes, formal verification and qualification of industrial drivers. 2. Integrate advanced modelling technologies, separating the model from the platform 3. Focus on the space robotics community, with requirements coming from actors leading robotics missions 4. Allow integration of complex robotics applications by including the Time and Space partitioning approach 5. Avoid vendor-lock in situations by delivering an open-source solution 6. Leverage on existing assets, such as already existing frameworks properly extended, mature toolsets and libraries) 7. Ease the development of robotics systems by providing a solution interoperable with other robotics frameworks (e.g. Rock/ROS third-party libraries and visualizers/simulator) 8. Cross-pollinate with non-space solutions and applications

Keywords: open source robotics operating system
Advanced wheel measuring system for greater rail sector’s profitability (WheelWatcher)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Spain,Spain,Germany,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 2718723.75
EU funding (EUR): 2065331.63
Participants: 5
Project status: CLOSED

The final aim of Wheel Watcher project is to boost the profitability of the railway sector by means of an advanced wheel status monitoring and control system, providing railway operators with accurate and real-time information on wheel wear to drive preventive maintenance actions thus avoiding premature replacement of this equipment. Main industrial impact of the project is to achieve a wheel life increase of 50%, and an increase of 25% of distance between wheel reprofiling actions, allowing the railway operator for conducting a remote but in-depth inspection of wheels. This industrial impact involves a subsequent relevant economic impact, targeting a cost reduction of 25% in maintenance-related costs as a result of less spare wheels and less low value-added works needed. These industrial impacts rely on relevant technical progresses: a high precision mechatronic platform addressing mechanical challenges derived of its wayside placement, a remote measuring unit comprising an ad-hoc thermoelectric cell guaranteeing thermal stability under potential extreme weather conditions, and a novel laser system doubling current power density available, able to measure trains moving at high speeds in outdoor locations, and a user-friendly control software including a self-diagnosis tool. WheelWatcher will have a deep impact on project’s partners, producing an aggregate profit of 23 M€ with more than 35 new jobs expected to be created, and a positive environmental impact due to less CO2 and less scrap. Excellence of the project will allow for dramatic improvements regarding the more relevant challenges faced by railway operators, as compared to the current state-of-the-art: automated high frequency wheel measuring, enhanced quality of measurements at normal speed (100 km/h) irrespective of weather conditions, remote monitoring without costly displacements to the tracks, no need of service disruption during measuring processes, and as consequence of all, a cut on operating costs.

Keywords: railway,high speed trains,maintenance,cost efficiency,laser triangulation,automatic,rolling stock,extreme weather