Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Proteome-wide Functional Interrogation and Modulation of Gut Microbiome Species (ProFITGut)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1499980.0
EU funding (EUR): 1499980.0
Participants: 1
Project status: SIGNED

The gut microbiome plays a key role in human health. Genomics approaches excel at cataloguing species composition, and associating imbalances with disease. Yet, as we are oblivious to the function of a large proportion of proteins of these organisms, we are limited in our understanding of the molecular mechanisms that drive disease or promote health. In this groundbreaking project we will systematically identify the function and interactions of proteins of microbiome species, deliver compounds to modulate them, and develop strategies to rationally manipulate microbiome composition. We will use a scalable systems biology approach based on high-throughput proteomics, using more than 100 drugs to perturb the proteome of a panel of 38 prevalent and phylogenetically diverse bacterial species that colonize the human gut. Proteins involved in the same biological process have coordinated changes in their levels across perturbations, allowing us to infer function based on annotated proteins. We will further assess which proteins are likely to physically interact as they co-aggregate upon heat-induced denaturation, leading to a map of the functional protein network of these species. We will then identify the mechanisms of action and resistance of the used drugs by using thermal proteome profiling, and by measuring intracellular drug concentrations. This will allow us to identify species that encode the target, but no resistance elements, so we can use the information to specifically deplete disease-associated species from microbial communities. These strategies extend beyond the strains studied in this project, as homologs of these proteins can be identified solely from genome sequences. Overall, this project paves the way for the microbiome field to move from associations to targetable mechanisms, with a vision to design therapies with reduced side effects to restore the microbiome to a healthy state.

Keywords: proteomics,microbiome,drugs,drug targets,drug resistance
IntraOral Scanning in dental Caries (IOSC)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Malta,Spain
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 161411.52
EU funding (EUR): 161411.52
Participants: 2
Project status: CLOSED

Caries disease is a global health and economy burden experienced by 2 billion of adults and 500 millions of children around the world. Visual exam and dental radiography are the standard methods for diagnosing and monitoring dental caries and present shortcomings: subtle lesions of caries cannot be visual or radiographically detected and are highly sensitive to the examiner; besides it, X-rays involve ionizing radiation which limits monitoring at small intervals and has structures superimposition. Recently, TRIOS 4 (3Shape, Copenhagen, Denmark) intraoral scanning (IOS) brings caries aid monitoring tool based on fluorescence and infrared technologies. Despite in vitro studies suggesting its applicability, there is no clinical evidence of its accuracy (true positives and negatives). In this context, the goal of this project is to clinically assess the accuracy of this novel approach for detecting and monitoring dental caries. After ethics approval, I will examine patient’s teeth under dental caries treatment in Faculty of Dental Surgery of University of Malta using visual exam and dental radiography, then I will scan teeth with TRIOS 4 IOS using fluorescence and infrared technologies. Using these clinical digital data, I will output: 1) the accuracy of TRIOS4 compared with standard methods; 2) if the result changes between professionals - in a multicentre approach. If firmly established, it will be a way to change caries monitoring in a safe and non-invasive approach; if not, it will provide scientific evidence for improvement, future studies and development of new tools. The results will be interesting for scientist, dentists, industry and citizens, as caries is a common disease with high global prevalence. For reaching such audience, communication, dissemination and exploitation is planned using open access practices through data repository, green and gold routes, as well as in mass media.

Keywords: dental caries digital dentistry intraoral scanning diagnostic imaging optical imaging
Promoting investments in NBS and accelerating market uptake by gaining a better understanding of the economic performance of NBS, considering climate mitigation and risk reduction (Invest4Nature)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Norway,Ireland,Denmark,Netherlands,Italy,Portugal,Latvia,Poland,Belgium
Call: The economics of nature-based solutions: cost-benefit analysis, market development and funding (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 4995172.5
EU funding (EUR): 4995172.5
Participants: 15
Project status: SIGNED

Currently there is a range of Nature-based solutions (NBS) emerging mostly with strong public funding elements, but a market for NBS has not yet emerged. While mostly small scale NBS are implemented as pilots for urban resilience to climate change the full range of economic and societal benefits for NBS are not systematically understood and mapped and are not sufficiently used to back the business and investment case for NBS. The numerous benefits may include mitigation and adaptation to climate change (including the reduction of urban heat island effect and flood mitigation), reduction of pollution, improved biodiversity and ecosystem services, increased well-being for citizens, including physical and mental health or recreation, social cohesion, and community building. While effort for climate change mitigation and adaptation are increasing, the role of NBS in this context is not well understood. In particular, risk reduction of NBS for the private and public insurance sector has not yet been systematically included in economic valuation of NBS. Holistic understanding of benefits and benefit flows however are important for the society including upscaling and maximising the benefits achievable with NBS and activation financing for NBS. The overall project aim of Invest4Nature is to gain a better understanding of the economic and financial performance of NBS, considering their role for mitigation as well as climate risk reduction, to promote upscaling and investments in NBS, and to accelerate market uptake. The project has a strong involvement of stakeholders to co-produce solutions, having several NBS Living Labs and a wide NBS community (including project developers, decision makers and funding and financing institutions) at hand, co-producing new evaluation and financing approaches as well as tools, covering NBS in different contexts (e.g., urban, rural, coastal). This is the basis for empowering stakeholders and create and structure a future NBS market.

Keywords: climate risk reduction,co development,decision support tool,living labs
Time Keeping with Epsilon-Near-Zero Metamaterials (TIMEKEEPER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Accurate time interval measurement and synchronization between two or more pulses are highly desirable in different fields of science and technology. Electronic components-based approaches can not measure the time difference between two events precisely below two-digit picosecond scale. Additionally, the use of highly expensive electronic components and temperature increase due to the heat generated within the system are other drawbacks, limiting its long-term use and performance. To address these issues, we propose to develop a novel, extremely high precision, low energy, all-optical timekeeping methodology and Timekeeper device with epsilon-near-zero (ENZ) metamaterials. Besides timekeeping, the technologies developed in this project can also become a powerful toolbox or an optical metamaterials technology platform, contributing to the creation of low-cost, accurate, practically light-based computing processes in future devices. Our work will have substantial implications on various areas of science and technology, including time and frequency metrology, geodesy, and astronomy. The developed all-optical time interpolation will enable extremely high precision of time events up to femtosecond scale using ultra-low power and exclude the high-speed electronics and high-temperature complications. The project results will apply novel metasurface-enhanced epsilon-near-zero (ENZ) materials to realize all-optical time-to-frequency converters and optical switches that can be used to realize low-cost, high-resolution (femtosecond) time-interval counters and optical gates.
Vernacular Literature and Medieval Universities. The Birth of a New Transnational Literary Identity (France and Italy, 1220-1399) (MEDLUNI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 297164.16
EU funding (EUR): 297164.16
Participants: 2
Project status: SIGNED

The rise of universities during the Middle Ages represented a major shaping factor leading to a paramount intellectual and cultural shift at a European scale, changing the way to communicate, to learn, and to think. MEDLUNI’s purpose is to shed a light on how medieval universities shaped a European literary identity during their rise and growth between 1220 and 1399. This goal will be pursued by investigating representative case studies across France and Italy, where medieval universities became the core and the cradle of a new vernacular literary tradition, establishing innovative paradigms in writing and spreading texts and knowledge. The scope of the project will be, on the one hand, to analyse how authors, texts and manuscripts began moving – more frequently and further away – from one university to the other, leading to the creation of literary networks all around Europe. On the other hand, I will aim at outlining how vernacular literature had been influenced by a range of international literary markers related to universities: new topics, disciplines, and styles. A deep transformation had been occurring, that still needs to be examined thoroughly and systematically by romance philologists. In addition, MEDLUNI will propose a replicable analytical model that would be applicable to other literary traditions. Aiming at filling a scientific and disciplinary gap, MEDLUNI will also settle a new scientific network between Università Ca’ Foscari and University of Fribourg, that represent two hubs of excellence and methodological innovation in the field of Romance philology. While my previous international and scientific experience would allow me to lead MEDLUNI proficiently, the MSCA-Global Fellowship would give me the paramount chance to act – for the first time – as a Principal Investigator, which would represent a key feature and a leap forward to my professional path.

Keywords: european identity medieval universities european literatures of the middle ages intellectual history medieval french literature medieval italian literature
A complex system approach to metrics of aging for identifying personalised interventions (LETMEAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Sweden,France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 3
Project status: SIGNED

The goal of LETMEAGE is to develop innovative methodologies for longitudinal aging metrics and the identification of personalised preventive interventions aimed at extending the healthspan and well-being in older age. The proposed framework views the aging individual as a complex system in which the dimensions of aging - from cellular mechanisms to disease and physical and cognitive function - interact dynamically with each other and with external factors (e.g., socioeconomic, environmental). Specifically, mathematical and statistical methods for longitudinal data will be extended and implemented to reflect clinically accurate and biologically detailed geroscience models. The methodology proposed in LETMEAGE will enable the estimation of subject-specific determinants of the aging process - including their impact on the lifespan- and personalised predictions. Additionally, tailored microsimulation methods will be developed to perform data-driven scenario analyses, estimating the long-term expected gain of hypothetical preventive interventions targeting risk factors for accelerated aging. Following methodological validation through simulations and real-data applications from two longitudinal population-based studies, all methods for estimation, model diagnostics, predictions, and scenario analyses will be integrated into an open-source software package. LETMEAGE is a highly interdisciplinary project combining applied mathematics, scientific computing, biostatistics, aging, and geroscience toward a more holistic approach to aging and geroscience research. By providing robust and advanced analytical methods, LETMEAGE will lead to the efficient utilization of high-quality longitudinal data to address the dramatic demographic increase of the older population. Ultimately, LETMEAGE will support the implementation of a personalized preventive framework toward healthy aging.

Keywords: geroscience,healthy ageing
Simulation Tools for the design of safe and sustainable Lubricants (SiToLub)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Italy,Ireland,Switzerland,United Kingdom,Germany
Call: Computational models for the development of safe and sustainable by design chemicals and materials (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6307730.58
EU funding (EUR): 5195467.19
Participants: 12
Project status: SIGNED

SiToLub project aims to develop a digital tool/platform for the Safe and Sustainable by Design formulation of new lubricants. The tools developed will provide assessment of the safety (toxicity to humans, ecotoxicity to environment and workers risk) and, at the same time, sustainability guidance to design ecofluids (coolants, greases, oils) in a clear and holistic way regarding the foreseeable physico-chemical properties and tribological performance. The safety assessment will be realized by using molecular dynamic models developed by the partners. The tribological models will allow the prediction of the energy consumption during use by providing friction force values, and expected durability of the materials by using wear data about the materials in contact with different fluids. they will also provide information about tthe degradation of the fluids in use and the chemical reactions occurring. The models will be flexible enough to predict the behaviour of the materials for different working parameters applied for different applications (wind turbines, electric cars and waterborne) This ambitious and forward-thinking system will leverage on a series of tools, ranging from technical evaluation and prediction models (computational models supported by artificial intelligence), combined with established Life-Cycle Analysis (LCA) methodologies to consider the environmental, social and economic impact. The project will move in close collaboration with already funded European projects as i-Tribomat (H2020 G.A. 814494) for the creation of a OiTB for tribological materials, OntoCommons (H2020 G.A. 958371) for the standardisation of data documentation across all domains related to materials and manufacturing and IRISS (HORIZON EUROPE G.A. 101058245), the international ecosystem for accelerating the transition to Safe-and-Sustainable-by-design materials, products and processes.

Keywords: lubricants,additives,simulation,safe,sustainable
Decoding Extracellular Vesicle-mediated organ crosstalk in vivo (CROSSTALK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

To coordinate activities between different tissues, multicellular organisms critically rely on intercellular communication. Whereas homeostatic signalling within organs is studied extensively, inter-organ crosstalk is only starting to be unravelled. In recent years, Extracellular Vesicles (EVs) have emerged as central mediators of this pathway by shuttling specific bioactive cargo including proteins between cells. These nano-sized lipid vesicles are released by virtually every cell type, are transported via the blood and combine the intricacy of cell-cell contact with the long-acting range of cytokines. However, due to their small size and a lack of suitable approaches, to what extent endogenous EVs mediate inter-organ crosstalk and support custom cargo delivery is unclear. I recently developed a unique transparent zebrafish embryo model expressing optical EV-reporters to examine endogenous EV biology at unprecedented detail in vivo. The aim of this proposal is to understand endogenous EV-mediated organ crosstalk by studying EVs secreted by the liver, the central metabolic hub in vertebrates. To this end, I will decode hepatic EV communication routes in vivo in health and liver pathology by exploiting my model system combined with novel tools and high-resolution microscopy. I will pursue three key-objectives: 1) Targets: mapping hepatic EV target organs; 2) Contents: analysing custom cargo delivery by hepatic EVs to specific target organs. 3) Function: determining the function of endogenous hepatic EVs by developing and applying molecular tools to interfere with their release in vivo. This project will provide the first advanced mapping of endogenous EV inter-organ crosstalk in a living model organism. By studying how pathology impacts EV mediated organ crosstalk and gaining precise control over EV release in vivo I will obtain unique insights into EV pathophysiology. In turn, this will open avenues for optimized diagnostics and therapeutic intervention.

Keywords: extracellular vesicles,exosomes,inter organ communication,in vivo,live imaging
Human communication as joint epistemic engineering (MINDSHARING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499105.0
EU funding (EUR): 2499105.0
Participants: 1
Project status: SIGNED

Imagine ordering a drink at a diner, pointing at an empty glass as an attentive waiter passes by. How did you select that particular gesture, and how could the waiter possibly interpret it as you intended? As any other signal we use to communicate daily, that gesture is highly ambiguous outside its context of use. How can human communication work by using referentially flexible and contextually dependent signals? MINDSHARING argues that interlocutors are communicatively effective because they jointly control their interaction-specific shared context. MINDSHARING integrates computational, developmental, and cognitive neuroscience to understand how that control is algorithmically defined, culturally acquired, and neurally implemented. First, using context-sensitive neural networks, MINDSHARING identifies communicative control parameters during interactive multi-turn linguistic and non-verbal referential games, then assesses the value of those parameters as potential communicative universals across worldwide cultures. Second, using prospective longitudinal studies, MINDSHARING identifies the socio-cultural experiences that influence the acquisition of communicative abilities during ontogenetic development. Third, using concurrent brain stimulation and imaging in communicating dyads, MINDSHARING tracks and perturbs the neural dynamics of communicative control parameters as dyads continuously adjust their shared context to novel communicative challenges. MINDSHARING provides a novel causal account of a foundational element of human society, the ability to communicate with referentially flexible signals. MINDSHARING brings computational, cultural, and neurocognitive explanations into the inter-personal space where communication is used and where it is learned. MINDSHARING will deliver what existing accounts have not delivered yet, multi-level causal explanations of the multi-level human ability to communicate with referentially flexible and contextually dependent signals.

Keywords: human referential communication social neurocognition experimental semiotics