Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantum Chemical Exploration of Reaction Networks: From Origins of Life to De Novo Enzyme Design (QCexplore)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2495175.0
EU funding (EUR): 2495175.0
Participants: 1
Project status: SIGNED

Gaining comprehensive insights into chemical and biochemical reaction networks is crucial for understanding and controlling molecular and catalytic processes; however, unraveling their intricate mechanisms remains a key challenge. QCexplore will provide a generally applicable solution to this challenge by developing an unbiased quantum-chemical reaction network exploration method and a highly efficient, fully automated open-source software framework. The starting point for these developments is our proof-of-concept approach of a computational hyperreactor introduced in 2024. By integrating reactivity-enhancing concepts – such as external acceleration of system components and elevation of the potential energy surface (hyperdynamics) – with fast, linear-scaling quantum-chemical methods, QCexplore’s framework will enable efficient and unbiased exploration of reaction networks under fully controlled and realistic conditions. The incorporation of novel data mining techniques, along with efficient refinement procedures, will allow for effective navigation and analysis of the reaction network’s data for identifying relevant reaction pathways. In this way, QCexplore overcomes traditional, manual and error-prone approaches to reaction mechanism elucidation. The performance of QCexplore’s developed framework will be demonstrated by tackling key questions in origins of life research, such as how essential molecular building blocks are formed and combined to create larger aggregates like RNA strands. Further, it will be applied to lay a robust foundation for de novo enzyme design by accurately identifying the key steps in catalytic processes, determining dominant reaction pathways, and uncovering strategies to enhance enzymatic activity and selectivity. The demonstrated versatility of the QCexplore framework is expected to open new avenues for the interplay between theory and experiment.

Keywords: quantum chemistry
NEXT GENERATION IMAGING FOR REAL-TIME DOSE VERIFICATION ENABLING ADAPTIVE PROTON THERAPY (NOVO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Türkiye,Germany,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 3759489.5
EU funding (EUR): 3759489.5
Participants: 9
Project status: SIGNED

The NOVO project will address a fundamental issue in proton radiotherapy (PT) of cancer, namely the lack of real-time dose verification (RDV) that significantly limits the potential of PT due to uncertainties in the precise delivery of the prescribed dose. In the NOVO project, we will develop the first proof-of-concept of an RDV technology adaptable to any PT treatment and bring the concept to TRL 4 by also considering integration into the PT clinical workflow. The RDV technology will be pivotal for enabling the next generation of adaptive PT therapy, i.e., dose-guided real-time adaptive therapy. Real-time measurement of the dose to targeted and non-targeted tissues will be the key to truly empower patient-centered, personalized cancer treatment, important to improve curation and quality-of-life post-treatment. As a high-risk/high-gain project, NOVO aims at a first-of-its-kind RDV technology through the unique synergy between (1) cutting-edge, inexpensive organic scintillator technology that can detect secondary radiation during treatment for non-invasive measurements, (2) novel and fast image reconstruction, artificial intelligence (AI)-accelerated models and AI-enhanced image reconstruction to allow simultaneous detection of multiple radiation species and tissue compositional analysis, (3) tumor-tracking and imaging of tissue radio-sensitivity based on oxygen levels, (4) intelligent automation of decision-making schemes for real-time dose-guided adaptive therapy. The project will essentially open a new era in PT that enables curing more cancer patients and reducing toxicity from treatment. The NOVO consortium covers the entire value chain of RDV development (technology providers, theory and modelling, technology integration and PT clinics) and optimally engages nuclear, medical, and high-energy physicists, chemists, mathematicians, computer scientists, oncologists, biologists, as well as European PT centers.

Keywords: radiotherapy,cancer treatment,dose verification,imaging,adaptive therapy
Long Life Power Platforms for Internet of Things (LoLiPoP IoT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Czechia,Ireland,Germany,Spain,Finland,Italy,Netherlands,Sweden,Türkiye,Switzerland
Call: General according to ECS-SRIA 2022 (RIA) (HORIZON-KDT-JU-2022-2-RIA, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 24397896.4
EU funding (EUR): 7699222.51
Participants: 41
Project status: SIGNED

In LoLiPoP IoT innovative Long Life Power Platforms will be developed to enable retrofitting of wireless sensor network (WSN) modules in IoT applications. This includes the development of algorithms to perform FUNCTIONALITIES like asset tracking and condition monitoring (for predictive maintenance). They can be used in APPLICATIONS such as industry 4.0, smart mobility and energy efficient buildings. LoLiPoP IoT creates an ecosystem of developers, integrators and users to develop these platforms thinking about power/battery life, ease of installation and maintenance. The project is driven by 12 laboratory- and field-based use cases to initially demonstrate their technical viability and then potential impact. Expected impacts from the LoLiPoP IoT use cases include; a) typical battery life increase from ~18 months to >5 years, b) Reduced maintenance overhead of mobile and fixed assets from >30% to <15%, c) Reduced costs related to location of assets typ. by €100Ks PA per use case, d) Optimised flow, management and throughput of assets through the identification of bottlenecks, yielding reductions of >10% in production time, cycle time and inventory costs, e) Improved comfort levels and well-being of building occupants whilst reducing energy footprint by >20% and f) Revenues of >€10M PA for LoLiPoP IoT industry partners offering asset tracking & condition monitoring services. All of this is achieved by developing and integrating: a) Multi-source Energy Harvesting solutions (vibrational and photovoltaic transducers, PMICs and discrete circuits), b) Digital interfacing to contextually adapt mode settings of WSN devices and connected systems to minimise power drain, c) Ultra low power components for WSN, d) Innovative Architectures for wireless data collection that minimize battery power drain, e) Simulation Models to optimise component design and integration and f) embedded AI/ML in IoT devices, for lower latency and power consumption and higher robustness.

Keywords: energy harvesting,power management,iot,asset tracking,condition monitoring,algorithms,industry 4 0,smart mobility,energy efficiency
Reducing climate based health risks in blue environments: Adapting to the climate change impacts on coastal pathogens (BlueAdapt)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Czechia,Spain,United Kingdom,Poland,Ireland,Netherlands,Italy,Belgium
Call: Health impacts of climate change, costs and benefits of action and inaction (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 6678353.75
EU funding (EUR): 6678353.75
Participants: 12
Project status: SIGNED

BlueAdapt brings together an interdisciplinary team of biologists, climate scientists, economists, epidemiologists and public health experts to investigate and quantify the future health risks associated with selected coastal pathogens. BlueAdapt will provide tools to assess the impacts of policy responses and communicate the results to a wide audience, including both policymakers and the public. A conceptual framework will be developed around existing models of One Health and Ecological Public Health, to help wider engagement with the complex nature of the issue. Horizons scanning and downscaled climate modelling will feed into lab based experiments and the development of simulations around how changes in climate variables, interacting with other environmental change, may influence the state of selected microbial pathogens of public health concern in coastal waters. Case studies will illustrate how One Health and Ecological Public Health concepts can be used to generate action and identify potential barriers to adaptation. Health impact assessment and cost-benefit analysis will inform appropriate action. BlueAdapt Innovation Slams and policy workshops will help deliver wider impact from the project including new-to-firm and new-to-market products and services.

Keywords: climate change adaptation,cost benefit analysis,decision support tools
Describing the Role of the Epstein-Barr virus And S1PR inhibition in the pathogenesis of Multiple Sclerosis (DREAMS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 310636.32
EU funding (EUR): 310636.32
Participants: 2
Project status: SIGNED

Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). One million people in Europe have MS, experiencing a significantly reduced quality of life and dying 7-14 years younger than average. The annual burden on European economies is ~€35B. Epstein-Barr virus (EBV) infects almost all Europeans and is aetiologically linked to MS with infection increasing disease risk 32-fold. Despite the huge personal, societal and economic impacts of MS, the underlying role of EBV in its development remains poorly understood. DREAMS will explore how EBV contributes to MS development. To do this, the Postdoctoral Fellow (PF) will utilise a novel humanised mouse model which harbours the major genetic risk factor for MS and is permissive for EBV infection. This model displays characteristics common with human MS, including CNS immune cell infiltration. Applying multiplex immunofluorescence, the PF will explore the nature of this immune infiltrate and how it is influenced by drugs used to treat MS, focussing on inhibitors of S1PR signalling. Combined with mechanistic in vitro studies to determine how these drugs interact with EBV-infected B-cells and EBV-specific T-cells, this work will allow new insights into how S1PR modulation affects MS immunopathology. As such, this research aligns with the Horizon Europe Health cluster and several UN sustainable goals, and meets Open Science, Gender Equality, Supervision and Green Charter guidelines. The PF will receive training in humanised mouse models, in vivo imaging and flow cytometry during an outgoing 24-month phase at the University of Zurich (Switzerland). This will be followed by a 12-month return phase at the University of Limerick (Ireland), learning in vitro T-cell assays. The PF will leverage the interdisciplinary supervisory team to meet the research & training objectives outlined, in preparation for an independent research career in the field of virus-associated diseases.

Keywords: epstein barr virus multiple sclerosis s1pr modulation
Pan-European Network for Neuroscience Research Infrastructure and Strengthening of Support capacities (PANERIS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Lithuania,Poland,Spain,Portugal
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 1046012.5
EU funding (EUR): 1046012.5
Participants: 5
Project status: SIGNED

Current challenges in European Research and Innovation (R&I) infrastructure in neuroscience include barriers for collaboration, funding gaps, undeveloped skills, or lack of alignment in R&I policies. PANERIS consortium aims to be more effective together by i) ensuring access to a wider pool of European talent to neuroscience-related infrastructure and ii) contributing to the alignment of their R&I strategies, policies and funding programs at institutional, regional and national level. Access to excellent neuroscience infrastructure and resources will be maximised through capacity building, tackling key skills, and setting a common internationalisation strategy among the participating entities. Three widening entities and one non-widening will promote knowledge exchange among early-stage researchers while addressing issues like research administration, communication, ethics, human resources, technological transfer or open science, among others. Moreover, interaction with key R&I networks will not only increase the global proficiency of consortium members but will also contribute to engage with regional and national authorities for the creation of valuable synergies in funding programs and policies. Overall, PANERIS will consolidate borderless R&I strategies in neuroscience, contributing to the free flow of knowledge and technology in the European Research Area.

Keywords: neurodevelopment,ageing,obesity,addiction,synergy
Preventing, avoiding and mitigating environmental impacts of fishing gears and associated marine litter (NETTAGPlus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Portugal,Spain,Malta,United Kingdom,Italy,Croatia,Ireland
Call: Marine litter and pollution – Smart and low environmental impact fishing gears (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 2316573.75
EU funding (EUR): 2177673.75
Participants: 15
Project status: SIGNED

NETTAG+ aims to provide a portfolio of three suitable innovative smart and sustainable solutions to address the negative impacts of fishing gears on marine life and habitats, in line with the second issue of the call “Environmental impacts of fishing gears”. NETTAG+ will be based on synergistic activities between the fisheries industry, scientists and NGOs to develop three solutions to PREVENT, AVOID and MITIGATE the harmful impacts of fishing gears. We will PREVENT marine litter derived from fisheries activities, AVOID loss of fishing gears, and MITIGATE harmful impact by removing existing ALDFG. These three solutions will jointly contribute to reduce ALDFG and marine pollution, namely by: reducing the introduction of hazardous chemicals and microplastics originated from ALDFG; reducing ghost fishing, bycatch and entanglements of sensitive or endangered species on ALDFG; and improving mapping, tracking and recovery technologies to retrieve ALDFG. NETTAG+ aims to upgrade and upscale the integrative preventive approach started in the previous NetTag project, and replicate it in Mediterranean regions. The three solutions will be developed to maturity (TRL 7-8) by the end of the project, and will be tested, validated and demonstrated in real conditions in Atlantic and Mediterranean countries, namely Portugal (PT), United Kingdom (UK), Spain (SP), Italy (IT), Croatia (HR) and Malta (MT). NETTAG+ ambition is to change the paradigm of the fisheries industry, aspiring to transform the societal perspectives about the role of fishers as Guardians and Cleaners of the Ocean. NETTAG+ will empower the sector to take active actions to address marine pollution, promoting their role as key-actors to tackle marine pollution, and will will provide the fisheries industry with three smart and environmentally-friendly solutions to reduce ALDFG and prevent the environmental impacts of fishing gears.

Keywords: harmful impacts of fishing gears acoustic tags and transponders fisher s based knowledge synergies between fisheries sector and scientists
Scalable Photon-Number-Resolving Integrated Cryogenic Electronics (SPICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Large-scale configurations of superconducting nanowire single-photon detectors (SNSPDs) are essential for quantum technologies such a photonic quantum computing, quantum communication and quantum sensing. Furthermore, spatial arrays of SNSPDs are ideally suited to light-starved applications such as deep-space optical communication (DSOC), single-photon imaging, microscopy, and spectroscopy. While SNSPDs offer near-unity efficiency, high timing resolution, and low noise, their potential is constrained by the lack of scalable photon-number-resolving (PNR) readout electronics. Indeed, the true bottleneck is not reliable detector fabrication but rather the wiring and signal processing required for large-scale SNSPD systems. This project will deliver in-situ cryogenic CMOS-based signal processing, enabling intrinsic PNR within each detector and signal processing from multiple detectors. By directly processing detection signals at cryogenic temperatures, we eliminate the need for individual high-bandwidth readout lines, drastically reducing footprint and heat load, thereby improving scalability. Furthermore, instead of traditional 50-ohm impedance matching, we leverage SNSPD signal transients and apply pre-programmed low-power processing to extract only the essential information from the detectors. This novel approach to data reduction at the point of detection has never been applied to SNSPD arrays but is a crucial step toward their widespread application. To achieve these goals, we leverage the research output of the ERC-StG project Quantum Engineering Superconducting Array Detectors in Low Light Applications (QuESADILLA) and a network of major European commercial and academic stakeholders. By addressing the core scalability limitations, this project will unlock the full potential of SNSPD arrays, paving the way for large-scale, energy-efficient single-photon detection systems tailored for next-generation quantum technologies and imaging solutions.
3Os and IP awareness raising for collaborative ecosystems (ZOOOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Germany,Finland,Slovenia,Bulgaria,Austria,Denmark
Call: Awareness raising on Intellectual property (IP) management for European R&I (CSA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 999000.0
EU funding (EUR): 999000.0
Participants: 11
Project status: CLOSED

ZOOOM aims to raise awareness on the importance of IP generation and management in collaborative innovation ecosystems which rely on three key assets, software, hardware and data. Open software, hardware and data are essential for a sustainable, trustworthy and sovereign industrial ecosystem. However, lack of competences in matching business models with appropriate licensing frameworks prevents unlocking the full potential of emerging technologies. ZOOOM departs from the concept that achieving strategic autonomy and technological sovereignty is possible through a sound understanding of what open licensing strategies are the best match for specific business models. This includes knowing when and to what degree it makes sense to stay open, and when going proprietary is the best strategy. The project aims to reach three core target groups actors in innovation ecosystems: knowledge generators, innovation support organizations and key stakeholders. Knowledge generators will benefit from tools for learning and supporting everyday development, increase competences on open licensing strategies for IP management, disseminate the concept and facilitate the application of IP management by identifying and suggesting viable business models enabled by open licensing strategies. Supporting organizations will get tools for internal training, support material to empower their clients, identify formats or services able to increase the reach of the IP management concepts and a database of cases analysed under the lens of open licencing and business development. Key stakeholders will benefit from a white book suggesting an integrated EU approach to open licensing of software, hardware and data as intertwined components of the innovation policy. This will set the basis for further research on the role of open licensing from a joint legal and business perspective, and guide the implementation of IP management and valorization in collaborative development platforms.

Keywords: open software hardware data awareness raising legal business toolkit trustworthiness licensing ip collaborative strategic value chains knowledge generators innovation agencies tto patlib dih edih