Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Grassa: Unlocking the full potential of grass (Grassa)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Sustainable protein production is crucial for a net-zero and resource-efficient food system. Grassa pioneers this revolution, reshaping biomass processing. The model spans grass/biomass protein concentrate, prebiotics (FOS), and plant-based fertilizer. Targeting dairy and arable farmers, through strategic stakeholder engagement, Grassa secures commitment from all relevant parties. Addressing societal challenges in protein production, it eyes a $770 bn market by 2032, aligning with EU strategies and UN SDGs. It will cut 20 tCO2 eq./ha/yr, yielding up to €1680/ha/yr for farmers and enhancing biodiversity. However, securing ample investment faces challenges due to investor caution and uncertainties around grass protein. Seeking an EIC grant, Grassa aims for transformative milestones, like European approval for grass as food ingredient. This blended financing strategy, combining external investments with the EIC grant, propels Grassa towards reshaping the grass/biomass-to-food industry.
NR2F6 Blockade as Adoptive Immune Cell Therapy for Metastatic Melanoma (NR2F6-AIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Melanoma cases and deaths are expected to increase in the coming years, representing a significant burden for the European economy and healthcare system. Metastatic melanoma (MM) is the most serious form of skin cancer and is characterised by uncontrolled metastatic spread of melanocytes to distant sites. Although standard treatments exist, significant clinical challenges remain, resulting in limited response and high MM recurrence rates. As a result of these limited treatment options, the quality of life of MM patients is dramatically compromised. Emerging immunotherapies, such as adoptive cell therapy (ACT), are promising but have significant obstacles, including long manufacturing times, high costs and, most critically, rapid exhaustion of infused cells due to the tumour immune microenvironment (TIME). Research in Gottfried Baier's lab has identified a unique way to effectively stimulate the immune system with an ACT by inhibiting NR2F6, an intrinsic immune checkpoint of T lymphocytes. This is done through our NR2F6 blockade-based adoptive immune cell therapy for metastatic melanoma (NR2F6-AIM) approach, where T cells are engineered for enhanced immune fitness prior to infusion. This greatly sensitises the patient's immune system to currently available immune checkpoint inhibitor therapy (ICT). This approach will permit us to deliver a combinatorial treatment that can overcome TIME immunosuppression, providing curative potential against MM. NR2F6-AIM will block NR2F6 by a non-viral, time-boxed gene silencing through a synthetic small interfering RNA (siRNA) transfection method. This method will allow us to overcome therapeutic manufacturing hurdles through a one-day in-hospital preparation of the ACT. NR2F6-AIM will verify and optimise the technology in relevant in vivo and ex vivo study models to validate the potential of this innovative ACT. It will also develop and execute an IP strategy and a commercial feasibility analysis to enter the MM market.

Keywords: multiple melanoma,adoptive cell therapy,nr2f6 as immune checkpoint
Prevention of Radiotherapy and Chemotherapy Induced Oromucosal Wounds Using an Oral Application Gel: Murnia® Mouth Gel (Murnia)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Türkiye
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Cancer is a devastating and costly condition expected to increase significantly by 2030. According to the 2018 WHO report, the global cancer burden is estimated at 18.1 million new cases annually . Mucositis is a condition in cancer patients that manifests as severe ulcerations in the mouth and the gastrointestinal tract. Oral mucositis (OM) is cancer treatment's most significant side effect worldwide . Mucositis can be caused by chemotherapy and/or radiotherapy. It occurs in nearly 40% of patients receiving conventional CT, 80% receiving high-dose CT as conditioning for haematopoietic stem cell transplantation, and 100% receiving H&N radiation therapy, with 65% of those progressing to severe grade levels with significant adverse outcomes. The problem with OM is that while current therapies are focussed on dealing with its symptoms like inability to eat or significant pain, there is no real cure or prevention for OM itself. Existing products in the market for OM mainly offer symptom management focusing on pain or, at best, duration reduction claims. The one approved drug for chemotherapy and radiotherapy, Amifostine, has severe side effects and tumour protective properties, making it hard to use as it interferes with the actual cancer treatment. Kepivance, which is only approved for haematological malignancies, is challenging to administer, posing compliance issues and does not solve the more significant need for solid tumours. Umayana has developed a proprietary preventative and curative formulation to combat OM in cancer patients. Global Patent: WO2020072987 USA Patent: 11331360 (B2).

Keywords: oral mucositis cancer,head and neck cancer,wounds
Cache-aided Folding for Reducing VoD Loads in Networks (LIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Communicating video-on-demand (VoD) over various networks is very costly. VoD drives up the costs for purchasing bandwidth and overprovisioning infrastructures, as well as the costs to content providers (Netflix, Amazon, etc.) that must pay large fees to network operators to deliver content to their clients. To reduce the massive VoD fees, networks employ caches. Our findings in our ERC project DUALITY reveal a new method of exploiting caches that boosts the performance of various networks. We wish to explore the practical ramifications of these findings in practical networks. This project will explore the algorithmic and testing work needed to render these ideas practical.
(Sustainable) Strawberry Fields Forever: Harnessing plant volatiles and optimizing agricultural practices in the management of pathogens in a strawberry production system in Sibate, Colombia (COLFRESA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,Colombia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 202582.8
EU funding (EUR): 202582.8
Participants: 2
Project status: SIGNED

Smallholder farming plays a crucial role in the food security and socio-economic stability of rural communities. However, their success is highly dependent on the profitability of crops, compelling farmers to intensify farming practices and widen profit margins. In the smallholder farming community of Sibate, Colombia, strawberry production has greatly increased over the past 2 decades. However, this crop is sensitive to infection by fungal pathogens, such as grey mould (Botrytis cinerea) and red stele disease (Phytophthora fragariae), of which outbreaks can decimate harvests. The intensive application of costly chemicals and expansion of cultivated lands to mitigate losses has led to the pollution of arable lands and threatens the endangered, highly biodiverse paramo ecosystem. I aim to provide the fundamental knowledge needed to develop sustainable management strategies and provide accessible information to promote its implementation. My first objective is to develop a causal model to predict disease outbreaks in the strawberry production system, with the aim of reducing the use of agrochemicals and optimizing irrigation practices. My second objective is to provide an alternative pathogen management strategy by making use of plant volatile organic compounds (VOCs). VOCs emitted by infected plants can be detected by healthy plants and invoke a pre-emptive immune response. I aim to explore whether VOC-induced immune responses can be used as a “green vaccine” in strawberries under the Sibate environmental conditions. My third objective is to develop a web-application that predicts disease outbreaks, in collaboration with the farmers, so that cost-effective and pesticide-reduction management will be implemented. Together, this project aims to become a showcase to develop sustainable agricultural practices together with small-holder farmers that will help conserve the unique paramo region, and help develop sustainable strawberry cultivation practices around the world.

Keywords: plant plant signaling,phytopathology,green vaccine,sustainable agricultural practice,smallholder farming,strawberry production,colombia
Social-Ecological ocean management Applications with Digital Ocean Twins (SEADOTs)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Research and Innovation actions
Countries involved: Norway,Germany,Sweden,Iceland,Serbia,Denmark,Belgium,Luxembourg
Call: Integration of socio-ecological models into the Digital Twin Ocean (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3299870.0
EU funding (EUR): 3299870.0
Participants: 9
Project status: SIGNED

SEADOTs (Social-Ecological Ocean Management Applications using Digital Ocean Twins) has the objective of advancing holistic, just and sustainable ocean management by bringing a predictive component for social-ecological aspects into comprehensive digital ocean twins (DOTs). These DOTs will combine digital twins of the ocean (DTO) with human activities in the ocean and combine socio-ecological and socio-economic data with ocean data, ecosystem data, and a variety of models. By creating and demonstrating applications in the Norwegian North Sea, the Southern North Sea and the Baltic Sea that address current challenges and developments and can simulate the intricate interactions between human activities and marine ecosystems, SEADOTs aims to facilitate and inform political decision making, marine spatial planning and adaptive management. SEADOTs ambition is to help safeguard ocean ecosystems, promote sustainable resource use, and enhance social and economic well-being. The project will leverage developments from ongoing Mission and Green Deal projects where partners are involved in, including the European Digital Twin projects Iliad and EDITO, OLAMUR and CLIMAREST and demonstrate Ocean Management Applications with Digital Ocean Twins on the EU Digital Twin Ocean (DTO) infrastructure as well as distributed platforms for socio-ecological, socio-economic and political endpoints. For that purpose will SEADOTs work with data acquisition and beyond the state of the art and the objective to provide spatially-explicit social-ecological data and data interoperability with geospatial ocean data also after the project period in suitable repositories, through stakeholder capacity building and through collaboration with the co-funded projects of this call. The SEADOTS consortium was built across scientific and technical excellence and is accompanied by an Advisory Board that spans marine spatial planning, political aspects, gaming and social science as well as Ocean Best Practices.

Keywords: socio ecological,socio economics,policy decision support,marine spatial planning,marine protected areas
Detector-Modulator Technology Utilizing Epsilon-Near-Zero Materials at Cryogenic Temperatures (D-TEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Photonic integrated circuit implementations hold great promise for quantum technology, but practical large-scale integration is limited by the capabilities and performance of key components for processing and measuring quantum information, particularly phase-shifters and single-photon detectors. Current modulators fall short due to either high losses, large size, slow speed, energy inefficiency and/or excessive heat dissipation, making them incompatible with superconducting cryoelectronics. In the other hand, while superconducting detector technology has seen significant progress, their integration into photonic circuits lacks the flexibility needed for dynamic (mid-circuit measurements, feed-forward) reconfigurability, as detectors need to be placed at the output of the network and classical data is only being retrieved at the final stage. Project D-TEC, addresses these challenges by exploiting a novel class of electro-optic modulator for quantum photonics at cryogenic temperatures, featuring the epsilon-near- zero (ENZ) effect. Specifically, indium tin oxide-(ITO)-based electro-optic modulators show a strong ENZ effect, which enhances the local optical field and produces a large refractive index change near the ENZ wavelength. When operated at liquid helium temperatures, two significant effects occur simultaneously. First, ohmic losses of ITO material are reduced, amplifying the local-field enhancement of the ENZ effect to unprecedented levels. Second, ITO exhibits superconductivity at critical temperatures below 5 K. It thus becomes possible to create phase modulators with performance far beyond the state-of-the-art and a completely novel type of single photon detector, with tunable photon absorption capabilities. These innovations enable fast, cryo-compatible circuit reconfigurability and the possibility of introducing feed-forward and mid-circuit measurements, enabling a new dynamic quantum photonic computing paradigm with vast potential for scalability.

Keywords: epsilon near zero,transparent conducting oxides,moscap,superconductor detectors,snspd,qpic
A Complete Transformation PAth for C-C backboned plastic wastes to high-value Chemicals and materials (ACTPAC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Denmark,Netherlands,Germany,France,Spain,Belgium,Türkiye,Austria
Call: Industrial biotechnology approaches for improved sustainability and output of industrial bio-based processes (HORIZON-CL6-2023-ZEROPOLLUTION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5098145.55
EU funding (EUR): 4765580.92
Participants: 12
Project status: SIGNED

Plastic pollution has become a clear threat to many environmental niches and ecosystems, due to rapidly increasing use of plastic products and leakage to the environment. Polyethylene (PE) is the most widely used and the largest-volume plastic (c.a. 30% of total plastics). Due to the absence of reactive groups, the C-C backboned plastics are often categorized as non-degradable; generally disposed by incineration or landfill (67%). About 12% plastic wastes are recycled as the goods with inferior quality and performance. The real catalytic route for upcycling of PE wastes into value-added products is <1%. It is clear that there is an urgent need to develop new routes for innovative upcycling of plastic wastes towards a paradigm shift in the plastic economy. ACTPAC proposes a complete value-added industry-viable path to convert PE firstly into alkanes; then into high-value chemicals (monomers); and finally into PE-like but fully biodegradable polyesters. Beyond the state-of-the art technologies, ACTPAC will design and deploy new catalysts and cross-metathesis modes for highly active and selective metathesis of PE into linear alkanes with a narrow distribution range (C6-C18, >90%). Two separate systems: multi-enzyme machinery assembled in the recombinant cells, and metabolic engineered yeast system, dedicated to the transformation of alkanes into monomers will be developed. Monomers of diversified chain-lengths will be used for the synthesis of polyesters presenting different properties and polymer performances, assignable for various applications. A zero-waste solution to the plastic waste management is thus created to keep them out of the environment, and reclaim their values. The new properties and specific applications of the new polyester plastics produced from upcycling of PE waste will bring up the SMEs with new business opportunities by scalable, flexible and robust multi-product manufacturing processes for on-demand and small-volume output production.

Keywords: plastic waste polyethylene bio based process upcycling biodegradable polymers polyesters enzyme engineering metabolic engineering zero waste management
The Significance of Bilingual Manuscripts for Detecting Cross-Language Interaction in the New Testament Tradition (BICROSS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium,Australia
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

BICROSS is an interdisciplinary project linking Greek, Latin, Syriac, Coptic, Gothic, Armenian and Arabic philology, New Testament textual criticism, manuscript studies, ancient history and digital humanities. Little is known about the bilingual New Testament manuscripts, although translations occur remarkably early. Their physical and textual characteristics, relations, tendencies and impact remain understudied despite their centrality to the understanding of the transmission of the New Testament and its reception in different cultures. For centuries New Testament manuscripts have been studied from a monolingual perspective which has obscured the fact that the textual transmission did not take place solely within the boundaries of a single-language tradition but also across languages. Uncovering and establishing the mutual exchange and cross-language interaction require a new multilingual approach to the New Testament tradition. BICROSS breaks through the current monolingual limitation by shifting the discipline’s focus to the overall New Testament tradition. Accepting the possibility that each variant reading could have had its potential source in a reading from a different language tradition and may likewise have caused a dependent reading in any of the other language traditions breaks new ground. The project’s bold and pioneering cross-language approach brings a fresh perspective to the discipline’s current search for new paradigmatic concepts to explain the relations of New Testament readings and manuscripts at large. BICROSS develops specific digital tools to process the vast and linguistically complicated manuscript data in order to pioneer an examination of the entire New Testament bilingual tradition on a larger scale than has ever been possible. The results will provide new insights into the formation and transmission of New Testament texts and will influence the understanding of historical, cultural and linguistic exchange in the East and West.

Keywords: new testament textual criticism bilingual manuscripts ancient translations ancient bible translations greek latin coptic papyri
Photodynamic Ocular Drug Delivery System with Optical Coherence Tomography Oriented Microscale Robots (PHOTODOCTOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Retinal diseases are the most common reasons of the irreversible blindness worldwide. Common retinal diseases, such as diabetic retinopathy, macular degeneration, retinal vein occlusion and non-infectious uveitis, mostly require intravitreal steroid injections in clinical management. Unfortunately, the intravitreal steroid injections, leads other important ocular problems, such as elevation of intraocular pressure, intravitreal infections and progression of cataracts. Because of these reasons, targeted drug delivery systems are necessity for the medical treatment of retinal diseases. PHOTodynamic Ocular Drug delivery system with Optical Coherence Tomography Oriented microscale Robots (PHOTODOCTOR) project combines three novel technologies to solve this important clinical problem. The first technological advancement for the project is dexamethasone saturated hyaluronic acid (HA) hydrogels with organo-ruthenium complexes, which enables controllable degradation under visible light exposure. With the help of visible light controlled degradation, dexamethasone will be released with the light pulses. Then the hydrogels will be supplemented with super paramagnetic iron oxide nanoparticles (SPIONs) and 3D printed as helical micro-swimmers. Insertion of the SPIONs will help the magnetic actuation of the hydrogel-based microrobots in the intraocular space. Lastly, SPIONs supplemented HA hydrogels will be observed with high resolution optical coherence tomography (OCT) system in the intraocular space to guide them in diseased area of the retina. While HA based structure increases penetration in vitreous and helps to the attachment on the retina, SPIONs will increase the visibility of the microrobots in OCT imaging. By this way, magnetic driven, visible light triggered intraocular drug release system with the OCT guidance will be produced and it could be used for not only intravitreal steroid delivery but also treatment of retinal tumors and other retinal problems.