Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hubble – smart workplace allocation platform (Hubble)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-04-01
End date: 2017-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hubble is a breakthrough SaaS platform which intermediates between SMEs searching for commercial real estate and providers with available property by offering a marketplace for commercial real estate to help manage the renting of excess capacity within offices and flexible service providers. Hubble provides best-class usability to find the right location quickly, and through the use of clear online contracts and payments, processed and recorded on the platform, adds unprecedented transparency to an otherwise, very opaque industry. The platform is disrupting the market by filling the gap left by traditional real estate agents, who are failing SMEs due to a lack of incentive and dependence on legacy business models and offers direct, tangible economic benefits to its target customers, by improving speed, reducing costs and increasing transparency. Hubble helps lower the barriers for new businesses, helps companies share office space and reduce their cost base, makes office space more affordable. Overall, the European economy benefits from more favorable business establishment conditions, more productive use of existing real estate assets, and job creation.In January 2017, Hubble counts 1,500+ registered offices, 20,000 desks mostly focused in the London area, which is approximately 2,5% of the local market, with a monthly revenue of £40K, generating a total of £500K in annualized revenue. The company has so far focused on the London market. It now wishes to expand into key cities across Europe and beyond. To enable this, the company is applying to undertake a six-month feasibility study through the Horizon 2020 SME Instrument Phase 1. The study will include a user review to assess needs and take-up, a technology review to enhance the product, marketing and sales analysis to test practical approaches, financial review to check assumptions and risks, an IPR review into patentability, and a full business plan to prepare for further financing.

Keywords: saas platform,real estate,office space,technology
Effective and Resource efficient cleaning system for X-Ray Personal Protective Equipment (PPE) (CLEANI-Rad)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

RealStar S.r.l., the worldwide leader in the manufacture of innovative high quality dry-cleaning machinery, with 198 employees and a turnover of 46 MLN €, and SIMAD S.r.l., a consolidate player in the X-ray Medical Technology sector, with 13 employees and a turnover of 3 MLN €, have developed, together, CLEANI-Rad, an innovative system to completely disinfect, in an automatic way, lead aprons used in hospitals to protect surgeons and patients against radiation, avoiding damages in the lead film, what results in an increase of the security for users reducing X-Ray exposure and risks coming from infections thanks to the total cleaning. Moreover, it does not exist direct contact between users and contaminants. This also means economic savings due to the reduced infection costs, that nowadays suppose 65 billion € annually in Europe, and new personal protective equipment investments. CLEANI-Rad its effective and resource efficient, as it supposes water savings, compared to hand-washing method, thanks to its water filter’s system, and a reduced amount of lead discharged to the environment (about 21 Kg/year per each 150 lead aprons). In addition, CLEANI-Rad is equipped with an innovative software that register every washing operation optimizing the control and maintenance of the lead aprons.

Keywords: lead,aprons,minimally non invasive surgery,water saving,hazardous,desinfection,x ray exposure,personal protective equipment ppe
Novel technology for biobutanol production (BUTANOVA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Butanol is a 4-carbon alcohol generally used as an industrial solvent with a growing multi-billion market and with a high potential as a renewable fuel. It is commonly produced from fossil fuels through very pollutant processes, strongly contributing to GHG emissions, and thus requiring more sustainable and greener production alternatives. During the past decade, some of the limitations in the biological production of butanol were tackled with the development of solventogenic microorganisms and advances in fermentation approaches. However, none of these solutions has reached industrial production and are either focusing on the less interesting isobutanol or based on anaerobic processes and still limited by to the use of Acetyl-CoA as the pathway precursor for n-butanol biosynthesis, thus limiting the process yield and productivities and the diversity of hosts that can be used and, consequently, the choice of feedstock. BUTANOVA technology is a novel biological alternative for the production of n-butanol based on an innovative and proprietary metabolic pathway developed by SILICO. BUTANOVA comprises a more efficient metabolic pathway, capable of higher yields, productivities and purity in either anaerobic or aerobic operation, for the production of n-butanol from a new precursor, alpha-ketoglutarate. Conversely to competing solutions, the use of alpha-ketoglutarate opens the door to a great variety of hosts and feedstock use. The major objective of BUTANOVA is the technology demonstration and market introduction of a cost-competitive alternative for the biological production of n-butanol, including the scaling-up and process documentation as part of Phase 2. To meet this end, it is required to first complete an IP risk analysis and technological/market feasibility evaluation in Phase 1. The successful accomplishment of the project objectives will position our company for high growth with expected revenues of more than 10M €, 5 years after project completion.

Keywords: biobutanol,metabolic engineering,strain optimization,biochemicals
'Fostering Resilience' in Front-line Environmental Management Practice: A Multi-Sited Ethnography of Novel Constellations of Environmental Value in Practice (FosResil)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2024-11-30
Duration (months): 36.0
Total project cost (EUR): 267480.0
EU funding (EUR): 267480.0
Participants: 1
Project status: CLOSED

Environmental management professionals (EMPs) have a crucial role to play in strengthening ecosystems and mitigating the effects of global warming. Given the fundamental unpredictability of climate change-associated events such as draughts or floods, however, EMPs are increasingly asked to 'foster ecosystem resilience', thereby enhancing ecosystems' capacities to bounce back from, or adapt to, unpredictable environmental stressors. As a recently emerged environmental policy paradigm, however, 'resilience' remains a contested concept. Commentators within sociology and the environmental humanities suggest that 'fostering resilience' may in fact preclude political and ethical engagement with the (man-made) stressors on environments, yet these perspectives have not paid empirical attention to resilience in actual environmental management practices. Meanwhile, studies in environmental management point to a concerning lack of comprehensive and empirical studies of the way 'resilience' is actually taking shape in environmental management practice. FosResil is designed to fill these empirical and analytical gaps. By means of a multi-sited ethnography of three pioneering resilience-based initiatives across Western Europe (UK, BE, and NL), FosResil seeks to examine and critically assess the ways in which 'resilience' is currently reshaping environmental management practice. Drawing on Science and Technology Studies in particular, it seeks to analyse how 'resilience' gives rise to novel forms of knowing, valuing, and managing environments. The first synthetic and comprehensive study of the resilience concept in environmental practice, FosResil's seeks to enhance public awareness of environmental management in an age of climate change, foster professional knowledge transfer and exchange, while its pioneering scientific achievement consists of its conceptualization of emerging notions of environmental agency and responsibility as they accompany resilience-in-practice.

Keywords: resilience,environmental policies,environmental management,valuing and valuation studies
Dynamic charging at moving contact lines (DynaMo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2474500.0
EU funding (EUR): 2474500.0
Participants: 1
Project status: SIGNED

Water drops sliding over hydrophobic surfaces can lead to surface charging. In contrast to charging caused by friction between two solid phases, drop slide electrification is largely unexplored. Slide electrification has been consistently reported, but results are difficult to reproduce. No theory or quantitative explanation currently exists. One reason for the lack of quantitative understanding is that the deposition of charge is a non-equilibrium effect and depends essentially on microscopic processes at the contact line. Slide electrification is relevant for the friction of drops and possible corrosion due to ions deposited on surfaces. It has potential as a means of power generation. Based on a recently developed lateral adhesion force apparatus (DAFI) and a new theoretical approach to describe slide electrification, we aim for a fundamental understanding of charge separation at sliding drops. Thus we plan to • identify important parameters for slide electrification (surface chemistry, substrate material, thickness, slide distance, velocity, drop rate, pH value, salt, atmosphere), and • construct a fast, inverted Reflectance Interference Microscope (RIM) to image the movement of the sliding contact line with unprecedented temporal and spatial resolution. RIM will be combined with DAFI and electronics to detect charge transfer. • Experiments using macroscopic drops will be complemented by moving micron-sized drops (<1 pL) over surfaces using a liquid probe microscope and simultaneously measuring the charge transfer. • Based on the microscopic processes identified above we develop a theory to predict charge transfer. Using this fundamental understanding, we will explore the potential of slide electrification for electric energy generation. Our objectives are to design a nano- and microstructured surface, which provides maximal power output, and build small scale devices to generate electric energy.

Keywords: contact angle,friction,tribocharging,wetting,contact angle hysteresis
Duality Symmetries, Higher Derivatives, and their Applications in Cosmology (Symmetries-Cosmology)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1793550.0
EU funding (EUR): 1793550.0
Participants: 1
Project status: SIGNED

The goal is to uncover symmetries and dualities of string theory including \alpha' corrections, to describe massive string states, and to investigate applications in cosmology. This will be done using double field theory and exceptional field theory and generalizing it to the non-local interactions of genuine stringy states and/or an infinite number of higher-derivative \alpha' corrections. So far these frameworks were mainly used to describe the low-energy effective field theories of the massless states in string/M-theory in a manifestly duality invariant way. The anticipated generalizations require a significant deformation or extension, of which we have only recently obtained first glimpses. Specifically, the higher-derivative corrections are constrained by gauge symmetries. These include the Green-Schwarz transformations, but are far more general and determine all corrections to first order in \alpha'. There was also recent progress on the problem of including massive string states: Sen proved that the sub-sector of string theory consisting of massless fields together with their Kaluza-Klein and winding modes provides a consistent truncation. The resulting theory must be governed by L_{\infty} algebras, which are generalizations of Lie algebras that so far have played little role in conventional field theories but now give us a concrete clue of how to construct a `true double field theory'. Various string cosmology scenarios have been suggested that aim to utilize stringy features for, say, the early universe. However, given our ignorance about the precise `stringy' Einstein equations, it has been impossible to test and verify such ideas, even theoretically. In view of the recent and forthcoming PLANCK data it has become particularly urgent to find a useful formulation of string theory in which problems of this type can be addressed and analyzed. If successful, this research program would be ground-breaking in that it would allow us to do precisely this.
Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy (ChemoBOOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The heterogeneity and capacity to evolve in response to treatment of the most aggressive forms of cancer make the selective inhibition of molecular targets an insufficient strategy to reach complete neoplastic remission. In this context, the unspecificity of classic chemotherapeutic agents becomes an advantage for treatment. Nonetheless, due to dose-limiting adverse effects, chemotherapeutic drugs become ineffective against some late-stage primary tumours, which are typically responsible for the death of the patient. To tackle those difficult to treat cancers, improved chemotherapeutic strategies far beyond the one-pill paradigm are mandatory. To reduce systemic side effects while increasing the levels of drug in the disease area, a number of novel methods originated from the Chemical Biology field (rather than from conventional Medicinal Chemistry approaches) have emerged during the last year to explore the site-specific activation of cytotoxic drugs. One of those novel concepts, pioneered by the Unciti-Broceta’s group in Edinburgh, is based on the use of palladium to activate drug precursors by heterogeneous bioorthogonal organometallic (BOOM) catalysis. Using an O-propargylation strategy to mask functional groups essential for the cytotoxic mode of action of clinically-used drugs, I will investigate the development of novel bioorthogonal palladium-labile prodrugs and their reactivation in cancer cell culture by heterogeneous palladium catalysis. With the support of a MSCA-IF, I intent to explore the full scope of this exciting experimental strategy, including the first ever approach designed to release two cytotoxic drugs with synergistic pharmacological activity from a single prodrug molecule.

Keywords: bioorthogonal chemistry,palladium,heterogeneous catalysis,chemotherapy,palladium labile prodrugs,combination therapy,bioorthogonal drug activation
Advanced Modelling Aided Design of Tissue Engineered Construct for Optimal Soft Tissue Repair (MADE-TEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

Articular cartilage (AC) is a connective tissue that is essential for smooth movement of our joints. Damage to AC leads to a debilitating joint disease called osteoarthritis (OA), which can cause severe restriction of joint movement and overall mobility. Currently, there are more than 40 million Europeans who are affected by OA. Tissue engineering approaches present promising treatment strategy through the replacement of the damaged tissues with tissue-engineered (TE) constructs. Although the current paradigm is to produce a cell-seeded biomaterial that matches the properties of the native tissue, such biomaterial may hinder growth and discourage replacement of the supportive biomaterials by newly synthesized proteins. Current TE constructs integrate poorly with the host tissue, with problems of interfacial gaps and compositional discontinuity, thus impeding their translation to the clinic. As cartilage cells are mechano-sensitive, we hypothesize that the mechanical signals conducive to cell biosynthesis can improve functional integration of TE constructs into host cartilage, and such mechanical signals can be tuned through carefully-designed TE constructs with optimal distribution of material stiffness and cell density. The aim of this research is to develop an advanced computational model that can simulate the biomechanical and growth behaviours of TE constructs and the host cartilage, and to use this model to determine optimal TE construct design that allows for functional integration into the host cartilage. The numerically-determined optimal design will be validated by state-of-the-art bioprinting technology and bioreactor testing. This computational biomechanical growth model will be the first-of-its kind as it can accelerate the design process and improve the performance of the TE constructs. This novel model can make a long-term impact on personalized design of TE constructs and have a high potential to advance the TE technique towards clinical translation.

Keywords: post traumatic osteoarthritis,articular cartilage,biomechanics of soft tissues and cells,finite element modelling,biofabrication,mechanobiology,integration,growth model
Social Innovation in Marginalised Rural Areas (SIMRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Italy,Egypt,Italy,Spain,Italy,Switzerland,Greece,Norway,Finland,Finland,Slovakia,France,Czechia,Netherlands,United Kingdom,United Kingdom,Lebanon,United Kingdom
Call: Unlocking the growth potential of rural areas through enhanced governance and social innovation (H2020-ISIB-2015-2, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 5935828.75
EU funding (EUR): 5575828.75
Participants: 28
Project status: CLOSED

SIMRA seeks to advance understanding of social innovation (SI) and innovative governance in agriculture, forestry and rural development (RD), and how to boost them, particularly in marginalised rural areas across Europe, with a focus on the Mediterranean region (including non-EU) where there is limited evidence of outcomes and supporting conditions. These objectives will be achieved by: 1. Developing systematic frameworks: a) theoretical - for improved knowledge of the complexity of SIs and its dimensions, and its impact on unfolding territorial capital; b) operational - based on a trans-disciplinary coalition (researchers and practitioners) to advance understanding of preconditions and success factors (e.g. instruments, incentives etc.) for implementing/operationalizing SI. 2. Creating a categorisation of SIs which encompasses the specificities in terms of social priorities, relationships/collaborations etc. and serves as an instrument to explore reasons why regions with similar conditions display diverging paths and to 'turn diversity into strength’. 3. Creating an integrated set of methods to evaluate SI and its impacts on economic, social, environmental, institutional and policy dimensions of territorial capital. 4. Co-constructed evaluation of SIs in case studies across the spatial variation of European rural areas, considering which components of territorial capital foster and, or mainstream RD. 5. Synthesis and dissemination of new or improved knowledge of SIs and novel governance mechanisms to promote social capital and institutional capacity building and inform effective options/solutions for shaping sustainable development trajectories. 6. Creating collaborative learning and networking opportunities and launching innovative actions at different/multiple scales, with continuous interactions among researchers, ‘knowledge brokers’ and stakeholders to foster and mainstream SI, leaving a durable legacy.

Keywords: rural areas,mediterranean region,territorial capital,multi actor approach,trans disciplinarity,operational framework,new governance mechanisms,smart,sustainable,inclusive rd trajectories