Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS (ARREST BLINDNESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Austria,Germany,Sweden,Belgium,Switzerland,Netherlands,Netherlands,Denmark
Call: Tools and technologies for advanced therapies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 6030052.5
EU funding (EUR): 5993177.5
Participants: 16
Project status: CLOSED

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

Keywords: regenerative medicine,cornea,transplantation,blindness,tissue engineering,stem cell,therapy
MARie Curie Intelligent UltraSound (MARCIUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Norway,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 1628564.4
EU funding (EUR): 1628564.4
Participants: 3
Project status: SIGNED

Cardiovascular diseases (CVD) are the number one cause of death in EU. Echocardiography is the most important imaging tool to assess cardiac function, since it is real time, cost effective and can be performed without discomfort and harmful radiation. A typical cardiac ultrasound examination takes 30-40 min, with image analysis and reporting doubling this time. Thus, cardiologists are now calling for a step change in diagnostic speed and accuracy to allow significant improvements for the care of CVD patients. We propose to develop intelligent algorithms to provide diagnostic support by automatic interpretation of regional cardiac contraction patterns and myocardial image texture. MARCIUS will leverage recent progress in machine learning to train a neural network to recognize unique disease states using a large database of patient data with known pathophysiology and outcome augmented with virtual patient data obtained using a well-validated mathematical model of the heart and circulatory system in combination with a beyond the state-of-the-art ultrasound simulation tool. The resulting diagnostic algorithm will be validated clinically. MARCIUS will take on research activities with high added value, both clinically for patients suffering from cardiac diseases, commercially for the industrial beneficiary and societally with reducing healthcare costs. The long-term and high-risk aspect of these activities makes them unsuited for execution within a normal product development context. Through training and knowledge development in a focused research project built on a unique combination of state-of-the-art technologies, MARCIUS will provide Europe with researchers trained with the cross-disciplinary understanding and skills necessary to develop enabling technologies in an industrial and clinical setting. The longer-term outcome of the project is new products, which will benefit patients across Europe directly by advancing the state of care within cardiology.

Keywords: echocardiography,deep learning,cardiac deformation imaging,diagnostic support
Biomolecular innovation and the evolution of animals: insights from taphonomy and the fossil record (Palaeochem)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 2460114.0
EU funding (EUR): 2460114.0
Participants: 1
Project status: SIGNED

What are the limits of the fossil record? Ancient biomolecules are critically important given their potential to inform on phylogenetic relationships and the processes driving evolutionary change. Research to date, however, lacks cohesion and breadth, is strongly biased towards bone, and often fails to consider the impact of analytical bias and fossilization processes. This proposal sets a new, focussed agenda for the study of ancient biomolecules based on the characterization of thin carbon films preserving the soft tissues of fossil animals. Targeted chemical analysis of diverse fossils including frontier high-resolution mapping will be informed by a rigorous programme of fossilisation experiments simulating decay and burial, thus generating the first holistic models for the preservation of the evolutionarily important biomolecules keratin, melanin, and collagen in fossil soft tissues through deep time. The research will resolve the fossil record of these key biomolecules, the chemical mechanisms responsible for their preservation, and will accommodate taphonomic biases in evolutionary models. This enhanced picture of animal molecular evolution will test hypotheses linking biomolecular innovation with fundamental phenotypic, phylogenetic and ecological transitions, especially relating to the evolution of the tetrapod integument and the origins of animals. The research will launch twin experimental facilities for simulating burial that will allow extraction, and in-situ analysis, of reaction products in real time. These facilities will be unique in Europe, consolidating the PI’s team as a keystone global hub for research into ancient biomolecules. The research team comprises the PI, three postdoctoral researchers, and two PhD students, and will dovetail with a global collaborative network. The project will have significance for diverse scientists and will inspire the next generation to explore the wonders of science.

Keywords: fossil preservation,fossil vertebrates,geochemistry,lagerstatten,keratin,melanin,collagen,ecological transitions,physiology
Targeted small-molecule Stabilisation of Protein-Protein Interactions (TASPPI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Germany,Belgium,Sweden,France,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 3342323.49
EU funding (EUR): 3342323.49
Participants: 12
Project status: CLOSED

The goal of the TASPPI European Training Network (ETN) is the establishment of a highly interdisciplinary research and educational training platform for early stage scientists in the Chemical Life Sciences to overcome the inherent boundaries between academia and industry and to increase their employability in both areas. To this end we have teamed up in a consortium comprising 5 partners from industry (AstraZeneca, GlaxoSmithKline, UCB, Lead Disocvery Center, Taros Chemicals) and 6 partners from academia (Universities of Dundee, Eindhoven, Leeds, Lille, Prague, and Siena). The scientific objective of the multi-sectorial Training Network is the development and implementation of a multidisciplinary technology platform bringing together structural molecular biology, chemical biology, cell biology, synthetic chemistry, and medicinal chemistry for the identification of Small-molecule Stabilizers of Protein-Protein Interactions (PPIs) as a novel class of therapeutic agents and basic research tool compounds. With this new technological approach we aim to address a number of unmet medical needs in the areas Cancer, Neurodegenerative Diseases (Alzheimer’s, Parkinson’s), Pulmonary Diseases, Inflammation and Metabolic Diseases (Diabetes).

Keywords: protein protein interactions,14 3 3 proteins,drug discovery,platform technology
SOLAR ADSORPTION REFRIGERATOR WITH THIN-LAYER/ENHAMCED ADSORBENT (SARTEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Increased energy costs, the uncertainty of fossil fuel availability, and climate change concerns, have necessitated the quest for renewable energy resources. Solar adsorption systems are quiet, simple to operate, and can last for a long time. However, they have low cooling power density, and subsequently have to be bulky compared to similar solar thermal systems offering the same performance. This can increase their initial costs, especially for small and medium sized systems, thus reducing their uptake. Currently researchers have successfully tackled this issue by, for instance, using more than one adsorbent bed to adopt a continuous cycle, and using forced cooling for the adsorber bed and condenser. These have not resolved the bulk/cost issues, however. This innovative Fellowship will apply a thin layer nano-particles embedded adsorbent, nano-fluid based refrigerants and selectively absorbing solar plate collectors to the system. We will develop a robust simulation model to help with the design process. The system will be partly built using a novel diffusion bonding process that enables dissimilar materials to be joined seamlessly. We will test the adsorption properties of the novel adsorbent materials and apply them to the refrigerator. We aim to deliver a solar adsorption refrigerator that employs nano-technology and novel manufacturing methods, meets the performance improvements currently achievable but not with the bulk and complexity. We expect scholars and industry to also apply the technology demonstrated to several other uses, and for them to be more accessible to the general public. The Fellow has all the necessary skills and experience required (including chemical adsorption, thermodynamics, heat & mass transfer) while the host lab has all the infrastructure and experience of hosting researchers. The project is also timely as it fits into the EU Energy policy (ESTPP Vision 2030).

Keywords: solar adsorption refrigeration,thermodynamics,chemical adsorption,adsorbents,nano particles
Low-cost LED headlamp system for increased safety, efficiency and sustainability in automotive lighting (LEDHEAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Hungary
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As LED lighting becomes more mature and affordable, it is increasingly used in a broad range of lighting applications. This includes automotive lighting: LEDs are already widely used for interior lighting and signal functions such as parking lamps, brake lamps and turn signals as well as daytime running lamps. LEDs are, however, still rarely used in headlamps, despite its advantages in terms of safety and environmental impact; and despite the fact that it represents the single largest market opportunity within automotive lighting. One of the major reasons for this apparent paradox is the cost for the automakers to implement them at a price the consumer is willing to pay. Hungaro Lux Light is developing is a novel optical system for motor vehicle headlamps, designed specifically for LED light sources. Our solution uses only refractive elements, resulting in better optical efficiency and far lower manufacturing costs than current solutions, making LED headlamps economically feasible across all vehicle classes. Increased use of LED headlamps will have considerable benefits both for the end-users and for the society at large: cost and energy savings; reduced environmental impact and better road safety. This proposal aims a Phase 1 project to define the optimal technological roadmap and commercialisation strategy for the successful market introduction of the LEDHEAD technology.

Keywords: led lighting,safety,energy efficiency,environmental impact,co2 emission
PolyUrethane Recycling towards a Smart Circular Economy (PUReSmart)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Germany,Germany,Italy,Belgium,Belgium,Belgium,France,France
Call: Smart plastic materials with intrinsic recycling properties by design (RIA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 6322088.04
EU funding (EUR): 5998573.75
Participants: 11
Project status: SIGNED

Thermosetting Polyurethanes (PU) provide a unique combination of durability, light weight, high strength and flexibility to high value consumer goods and other applications. PU thermosets have grown to a global market of 50 billion €, ultimately resulting in high volumes of waste mostly disposed via landfill or incineration as the SOA of the recycling technology is limited. PUReSmart will bridge the gap between the current PU linear economy to a circular model by designing smart polyurethane materials that can be reshaped into new products with undiminished quality. PUReSmart will provide solutions for the identified three scientific-technological urgent needs that require conceptual breakthroughs: 1) Smart DESIGN of covalent adaptable polyurethanes (CAPU) to bridge the gap between thermosets and thermoplastics, thanks to thermally reversible bonds; these CAPU are reprocessable, similarly to thermoplastics. 2) Smart SORTING, using the unique spectroscopic fingerprints of conventional PU and smart building blocks to create a validated and cost effective PU sorting platform with high specificity and sensitivity; this enables driving CAPUs to reprocessing and PU to chemolysis. 3) Smart CHEMOLYSIS with mass balanced and minimized input of virgin chemicals, maximal purity and efficient isolation of the obtained building blocks resulting in full re-utilization of all obtained fractions for PU or CAPUs; PUReSmart will integrate CAPU chemistry with monomers obtained by next-generation chemolysis processes, using well-sorted feedstocks, aiming at scalable industrial products (TRL 5) with social and economic value assessed by a Life Cycle Analysis for ‘cyclic’ PU. The project encompasses a concerted effort of partners along the value- and revalorization chain: PU producers, producers of the building blocks, technology providers for physical sorting, and research institutions focusing on design of new PU types and on innovative chemolysis methods for existing PU types.

Keywords: polyurethane,flexible foam,chemolysis,sorting,design,covalent adaptable networks,polyurethanes,vitrimers,spectroscopic,thermoset,circular,tad indole click chemistry,optical sorting
Neuro-metabolic, structural and functional hallmarks of Lysosomal Storage Diseases (NeuroLSD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2022-04-02
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Continuing development of novel brain treatments, which bypass blood-brain barrier, further emerges the need to establish prognostic magnetic resonance (MR) markers to track progressive brain alteration in lysosomal storage diseases (LSD). Excessive intracellular accumulation of lysosomal substances such as glycosaminoglycans in mucopolysaccharidosis (MPS), globotriaosylceramide in Fabry disease and glycocerebroside in Gaucher disease (GD) triggers multi-organ malfunctioning and significant damage to the central nervous system. While LSD are associated with various levels of cognitive deficits, and distinct extents of morphological brain abnormalities (e.g., atrophy, leukodystrophy or enlarged perivascular spaces) ranging from non-existing in GD type 1 to severe in MPS type 2, microstructural and metabolic processes have not been comprehensively described in brains of LSD patients in vivo yet. We will utilize cutting-edge accelerated proton MR spectroscopic imaging methodology that was developed at the Medical University of Vienna in combination with advanced diffusion MRI, high-resolution T1-/T2-weighted ratio, and pseudo-continuous arterial spin labeling technique. Our protocol will reliably quantify levels of all relevant brain metabolites, while sensitively describe microstructural and functional deficits to determine the relevance of MR measures in psychological deficits in LSD. Reproducible MR methods are needed to assess effects of novel treatments that overcome blood-brain barrier such as intrathecal enzyme administration, chaperones and gene therapies in clinical LSD trials. Increased understanding of brain LSD pathology will critically boost search of optimal therapies in age-related neurodegenerative diseases that share some common features with LSD such as Alzheimer’s or Parkinson’s disease.

Keywords: lysosomal storage diseases,brain,cognitive performance,magnetic resonance spectroscopy imaging,diffusion magnetic resonance imaging,arterial spin labeling
A novel approach to non-invasive and personalized skin cancer diagnosis (OCTAV)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 3485857.0
EU funding (EUR): 2400000.0
Participants: 1
Project status: CLOSED

French SME-company DAMAE Medical is facing skin cancer worldwide issue by developing the OCTAV Project, a new approach to dermatological diagnostic based on a disruptive Line-field Confocal Optical Coherence Tomography (LC-OCT) technology, in a novel hand-held imaging device. OCTAV is designed to capture in situ images of the skin layers with a cellular resolution. It is used in conjunction with dermoscopy to provide more accurate diagnosis, leading to fewer biopsies of benign lesions and earlier detection of melanoma (clinical use 1) and non-melanoma skin cancers (clinical use 2). It may also guide the surgery to provide more accurate presurgical margins (clinical use 3), preventing unnecessarily large scars and reducing the risk of recurrence. Correlatively, DAMAE is developing a full software solution, based on a data storage cloud-platform, a computer-aided software designed to assist dermatologists with OCTAV image interpretation, as well as telepathology and patient services. OCTAV device will initially be used by clinicians as a routine easy-handling diagnostic device in public practices (market segment 1). Implementation of OCTAV software will enable its adoption by a much larger market, consisting of private practices dermatologists (market segment 2). The approach will contribute to the development of skin cancer risk patient awareness, while changing the current paradigm through a timely, performant, and non-invasive approach, and releasing the financial burden on the healthcare system. Project OCTAV has successfully completed in 2017 a feasibility phase covered by the SME Instrument Phase 1, resulting in a TRL6 prototype of the technology and a first consolidated atlas of skin cancer clinical images. The main objective of this Phase2 is to scaleup the OCTAV solution to TRL9 through industrialization activities and by achieving a definitive market assessment, the clinical validation and the regulatory approval, before deploying the approach worldwide.

Keywords: medical devices,onco dermatology,skin cancer,melanoma,optical imaging,non invasive,3d imaging,smart atlas,industrialization,clinical trials,life saving,cost saving