Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Terahertz technology for ultra-broadband and ultra-wideband operation of backhaul and fronthaul links in systems with SDN management of network and radio resources (TERAWAY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Finland,Greece,Greece,Netherlands
Call: 5G Long Term Evolution (H2020-ICT-2019-2, 2019)
Start date: 2019-11-01
End date: 2023-08-31
Duration (months): 46.0
Total project cost (EUR): 5999498.88
EU funding (EUR): 5999498.75
Participants: 14
Project status: SIGNED

TERAWAY will develop a disruptive generation of THz transceivers that can overcome the current limitations of THz technology and enable its commercial uptake. Leveraging optical concepts and photonic integration techniques, TERAWAY will develop a common technology base for the generation, emission and detection of wireless signals within an ultra-wide range of carrier frequencies that will cover the W (92-114.5 GHz), D (130-174.8 GHz) and THz band (252-322 GHz). In this way, the project will provide for the first time the possibility to organize the spectral resources of a network within these bands into a common pool of radio resources that can be flexibly coordinated and used. In parallel, the use of photonics will enable the development of multi-channel transceivers with amplification of the wireless signals in the optical domain and with multi-beam optical beamforming in order to have a radical increase in the directivity of each wireless beam. At the end of this development, TERAWAY will make available a set of truly disruptive transceivers including a 2- and a 4-channel module with operation from 92 up to 322 GHz, data rate per channel up to 108 Gb/s, transmission reach in the THz band of more than 400 m, and possibility for the formation of wireless beams that can be independently steered in order to establish backhaul and fronthaul connections between a set of fixed and moving nodes. TERAWAY will evaluate these transceivers under an application scenario of communication and surveillance coverage of outdoor mega-events using moving nodes in the form of drones that will carry a gNB or the radio part of it. The network during the implementation of this scenario in the 5G testbed of AALTO will be controlled by an innovative SDN controller that will perform the management of the network and radio resources in a homogeneous way with large benefits for the network performance, energy efficiency, slicing efficiency and possibility to support heterogeneous services.

Keywords: terahertz communications,w band,d band,ultra wideband operation,multi beam optical beamforming,unmanned aerial vehicles uavs,localization,sdn control,radio resource management
Advanced catalyst electrodes from Ionic liquid modified PtNi nanowire arrays for PEFCs (IonPEFC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-03
End date: 2019-08-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Recent developments in PEFC research have seen a significant enhancement of catalyst activities and a reduction of cost at a reduced loading of precious metals by employing novel Pt-based extended surface area nanostructures alloyed with transitional metals, but the low stability caused by the easy dissolution of transitional metals in acidic PEFC environment, and the large difficulty to be integrated into devices due to the unconventional morphology of extended surface area nanostructures as Pt/C nanoparticle catalysts limit them mainly to pure material research, resulting in an increasing gap with real high performance devices. IonPEFC will bring together the chemistry of nanostructure and ionic liquid (IL) synthesis with the engineering of fuel cells to develop PEFC electrodes with thin film catalyst nonstructures from PtNi nanowire arrays modified by protic ILs, targeting an improved understanding of structure-property relationships of electrodes to build high performance and robust PEFC devices. This will involve 4 research objectives: 1. To develop electrodes with thin film catalyst nanostructures from PtNi nanowire arrays based on the in-situ growing approach and to study the effect of post acid washing and annealing on the surface properties of PtNi nanowires. 2. To synthesize super hydrophobic, electrochemical and thermal stable ILs with high proton conductivity, oxygen solubility and diffusivity. The as-prepared ILs will be used to modify PtNi nanowire electrodes obtained to protect catalyst surface from Ni leaching in fuel cell operation. 3. To test in single cells the as-prepared and IL modified PtNi nanowire electrodes, and compare with conventional Pt/C electrodes. 4. To evaluate the long-term durability of the electrodes under real life-context at different European and international automotive driving cycles with the industrial partner. It is expected that substantial performance and durability improvements will result from this research.

Keywords: polymer electrolyte fuel cell pefc,electrodes,nanostructure,pt nanowire,ionic liquid,ptni,oxygen reduction reaction
All-electrical analytic platform for digital fluidics (ANALYTICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Prospective biosensing technologies will need to tackle the grand challenges arising from the global demographic changes. Among the most crucial tasks is the monitoring of food and environmental quality as well as the medical diagnosis. Digital fluidics offers vast advantages in performing these tasks relying on tiny containers with reacting biochemical species and allowing massively parallelized assays and high throughput screening using optical detection approaches. I envision that adding not-optical detectors, which electrically probe the analyte responses, will provide a source of new but complementary information, obtained in a label-free and contactless manner. Hence, these all-electric platforms enable monitoring the kinetics of chemical reactions in lab-on-chip format, as well as take over auxiliary tasks, e.g. indexing, counting of droplets, flow monitoring. In frame of the ERC project SMaRT, my team developed a unique detection platform -millifluidic resonance detector- that inductively couples to an analyte and assesses its physico-chemical properties. The unique selling points are (i) non-invasiveness to analyte, (ii) unnecessity of a transparent fluidic channel, (iii) cost efficiency and (iv) portability. Implementing the input from the partner companies, here I aim to reach the commercialization stage pursuing a number of key milestones, i.e. enhance the screening throughput, realize a platform independent of external electronic devices, provide a temperature stabilization of the response, and develop the app. Societal benefits: We demonstrated that the device provides an access to the metabolic activity of living organisms in droplets. This is way beyond the capabilities of the state-of-the-art optical detection. With this feature, the device can address the issue of increasing antibiotic resistance of bacteria and thus help to optimize the antibiotic policy in hospitals and households and to test new drugs in a time- and cost-efficient way.

Keywords: droplet fluidics,flow monitoring,digital fluidics,detection platform,metabolic activity of bacteria
CEREALPATH - Training in innovative and integrated control of cereal diseases (CEREALPATH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Germany,Ireland,Ireland,Germany,Ireland,Germany,Ireland,Ireland,Switzerland,Switzerland,Sweden,France,Denmark,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-12-31
Duration (months): 52.0
Total project cost (EUR): 4013668.8
EU funding (EUR): 4013668.8
Participants: 20
Project status: CLOSED

There is a massive and urgent effort needed to ensure security of food supply for the growing world population. This challenge of doubling crop yields by 2050 provides the motivation for this project, entitled Cereal Pathology – training in innovative and integrated control of cereal diseases (CEREALPATH). Cereals are the most important source of human calories, but we lose billions of euro worth of grain annually due to diseases that reduce yield. CEREALPATH is a multidisciplinary, multisectoral training programme built using the complimentary expertise from 22 participants from 8 European countries, including 7 Universities, 3 research institutes, 11 industry and one regulatory agency. The consortium will combine and share expertise in different approaches to disease control to offer standardized, high quality doctoral training at an advanced level to 15 ESRs. CEREALPATH will expose researchers to research and innovation in both industry and academia. The training equips researchers with the skills and opportunities to develop innovative methods contributing to integrated disease control programmes, thus matching their potential to the jobs of the future and helping Europe and the world meet the critical need of global food security.

Keywords: crops,cereals,disease,breeding,biocontrol,trade off,food security,wheat,barley
Monoclonal Antibodies with Binding Sensitive To Environmental Regulation (MABSTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

Keywords: phage display technology,antibody engineering,snakebite envenoming,recombinant antivenom,monoclonal antibodies,toxin neutralization,antibody discovery
Jet Tomography (JetT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The nuclear matter produced in heavy-ion collisions starts as a far-from-equilibrium system with an energy density so high, that the quarks and gluons normally confined inside protons and neutrons, form a continuous medium. Soon after, this medium thermalizes into a nearly ideal liquid known as the quark-gluon plasma (QGP) which exhibits pronounced collectivity, indicating that its constituents are not confined. Studying the multi-phase evolution of this hot and dense medium is particularly interesting, since it allows to access such fundamental properties of nature as the colour confinement and the origin of complex matter in the universe. However, experimental studies of this system are highly non-trivial since the information about the QGP evolution is entangled in correlations of energy and momenta of billions of particles. An opportunity to overcome this issue is provided by hadronic jets -- sprays of particles produced by energetic quarks or gluons leaving the QGP fireball. These energetic particles penetrate the matter, lose their energy, and have the structure of the final jet modified. Thus, jets essentially X-ray the QGP fireball providing a picture of its real-time evolution. The idea of using energetic particles for tomography of the medium has attracted significant attention in recent years. However, all current theoretical approaches are either lacking sensitivity to the medium motion and in-medium fluctuations or are based on empirical models. In the JetT project I will utilize recent advancements in first principle QCD and jet theory to develop a description of the jet-medium interaction sensitive to medium motion effects. This will provide much needed tool to study the evolution of the matter produced in HIC bringing the idea of jet tomography on completely new level.

Keywords: heavy ion collisions,hadronic jets,quark gluon plasma,jet tomography
Extending the science perspectives of linear wires of carbon atoms from fundamental research to emerging materials (EspLORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1981875.0
EU funding (EUR): 1981875.0
Participants: 1
Project status: CLOSED

EspLORE aims at addressing the potential of carbon-atom wires for developing novel functional coatings in an application-oriented approach. Carbon-atom wires, based on sp-hybridization, are the ultimate 1-dimensional carbon nanostructure (1-atom diameter) with functional properties strongly dependent on the wire length and termination. The design and control of the wire structure opens the way to build materials with tunable properties, which is at present a largely unexplored topic. The core concept of EspLORE is to exploit the present fundamental knowledge of carbon-atom wires as isolated molecules/nanostructures to explore the applied science and engineering of new materials in the form of thin film assemblies and nanocomposites, so to fill the large existing gap between basic science and engineering. To this aim the main challenging goals are: 1) the controlled synthesis of wires; 2) the development of strategies to assemble wires in thin films and nanocomposites; 3) the exploration of potential use of wire-based materials in direct energy conversion devices (e.g. photovoltaics, water splitting, fuel cells). The proposed methodology includes fabrication of wires by physical methods, their deposition/assembling on surfaces, and the experimental study of structural, electronic and optical properties. Structure-property relationship is investigated at a multiscale level, moving from the single wire level (atomic scale) to multi-wire interactions (nanoscale) and up to extended systems (macroscale). The outcomes of the project will put the foundations for the materials engineering of wire-based systems and their realistic implementation in advanced technological applications. These materials, able to provide complementary properties to graphene, will synergistically contribute to open new perspectives for an innovative ‘all-carbon’ approach to present and future challenges in many fields of engineering and technology.

Keywords: carbon nanostructures,polyynes and cumulenes,thin film deposition,pulsed laser ablation,in situ raman and sers,in situ scanning tunneling microscopy stm,electrical and optical properties
Soft Artificial Muscles (SAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

The development of bioinspired materials that mimic animal muscles is a key step in the advancement of several scientific fields, including robotics and medicine. Muscles exhibit a unique combination of softness, mechanical resistance, adaptability and the ability to undergo large anisotropic deformations, which is so far unmatched in artificial materials. This action will develop a novel class of nanocomposite materials that mimic natural muscles by combining stimuli-responsive hydrogels (SRH) and colloidal liquid crystals (CLC). SRHs consist of a network of stimuli-responsive polymer chains and a high fraction of water. By changing the solubility of the polymer with stimuli such as temperature and light it is possible to control the amount of water in the network, thereby producing large volumetric variations. SRHs are soft and shape-compliant actuating materials like muscles, but they generally exhibit poor mechanical resistance and the volumetric expansion has no preferential direction. These limitations will be overcome by attaching the stimuli-responsive polymer chains to anisotropic colloidal particles and assembling these building blocks in a uniaxially oriented manner like CLCs. The resulting nanocomposites will be soft, yet strong, capable of actuation-like conventional SRHs, and their expansion/contraction will be directional, thanks to the preferred orientation of the colloidal particles. The proposed platform will rely on rod-like cellulose nanocrystals (CNCs) that will be decorated with cross-linkable poly-N-isopropylacrylamide chains bearing photoresponsive spiropyran units (poly-spiropyrans, PSPs). CNCs are inexpensive, biocompatible and can be easily extracted from renewable resources, while PSPs are known to form photoresponsive hydrogels. The combination of these elements and integration into uniaxially oriented structures will afford a novel class of soft actuators that will bring significant advancement to fields like robotics and medicine.
Preventing and reversing neuroinflammatory brain damage using local expansion of regulatory T cells (TreatBrainDamage)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

A proposal to use local IL2 delivery via a viral vector to prevent and reverse the inflammatory damage that happens to the brain during neuroinflammatory diseases as diverse as traumatic brain injury, Multiple Sclerosis and Alzheimer's Disease. In "TissueTregs" we identified and characterised a brain-resident regulatory T cell population, with high expression of anti-inflammatory and reparative proteins. A synthetic circuit for deliver IL2 to the brain expanded this population, without any off-target increases in circulation or the blood. In order to translate these findings beyond the scope of the original "TissueTregs" grant, we have moved to a viral vector system, designed to give brain-specific expression of IL2. This systems demonstrates long-lasting brain-specific expansion of the brain-resident regulatory T cell population, after only a single intravenous injection. Preliminary results demonstrate a striking ability of this treatment to prevent neurological damage in mouse models of traumatic brain injury and Multiple Sclerosis. A provisional patent has been filed to cover this invention. In this PoC grant, we will run the necessary validation and target deconvolution experiments to pave the way for this treatment to move into the clinical sphere.

Keywords: regulatory t cells,traumatic brain injury,multiple sclerosis,neuroinflammation,interleukin 2,gene therapy,viral vectors,alzheimer s disease