Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements (VINCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1940025.0
EU funding (EUR): 1940025.0
Participants: 1
Project status: SIGNED

The preparation of complex molecular architectures employing multi-component reactions where the number of bond-forming events is maximised is a central goal of the discipline of Organic Synthesis. The contemporary, pressing need for sustainable chemical reactions has raised the demand for novel reaction families that explore the concept of redox-neutrality and proceed with the generation of minimal waste. In this proposal, I present a unified and conceptually novel approach to atom-economical C-C bond formation in challenging contexts without the need for transition metal promoters or reagents. To this end, I propose the innovative harvesting of the potential of vinyl cation intermediates as platforms for the deployment of nucleophilic entities capable of orchestrating rearrangement reactions. The combination of such high-energy intermediates, generated under mild conditions, with the power of carefully designed rearrangements leads to an array of useful new transformations. Furthermore, the very high atom-economy and simplicity of these reactions renders them not only sustainable and environmentally friendly but also highly appealing for large-scale applications. Additional approaches to enantioselective synthesis further enhance the methods proposed. The paradigm proposed herein for the exploitation of vinyl cations will also open up new vistas in the centuries-old aldol reaction and in amination chemistry. This showcases the vast potential of these simple principles of chemical reactivity. The myriad of new reactions and new product families made possible by VINCAT will decisively enrich the toolbox of the synthetic practitioner.

Keywords: rearrangements,redox neutral,c c coupling,vinyl cations
Genomics and Mechanisms in Translational Medicine Doctoral Programme (GenomMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-04-01
End date: 2022-12-31
Duration (months): 69.0
Total project cost (EUR): 2511360.0
EU funding (EUR): 1255680.0
Participants: 1
Project status: CLOSED

The GenomMed programme will train international experts who are wanted in the European job market and future research leaders in translational genomics. These experts aim to solve health care -related questions in cardiovascular and metabolic diseases and neurosciences. They will have skills to create solutions and innovations to develop novel treatments in the European and global environment. Health care is globally faced with a growing burden of major age-associated diseases. New means of diagnosis and treatment are needed to survive the challenges. This will be gained by offering world class research-oriented PhD training in genomics, cardiovascular and metabolic diseases, neurosciences, and clinical adaptation of research results. In depth knowledge and methodology training will be topped up with well-planned transferable skills curricula providing the graduates with skills needed in changing career paths after their initial researcher training. Other means to achieve training goals include well-planned mobility periods to international collaborators’ research environments, meaningful secondments at intersectoral partners’ projects, and frequent exposure to interdisciplinary activities between the participating research groups. The GenomMed Doctoral Programme will take the researcher training to the next level in terms of research excellence, productive international and intersectoral mobility, and interdisciplinary exposure. Graduates will gain a unique set of research and transferable skills. Career development is a built-in feature of the training leading to increased employability of graduates in and outside academia and enhanced R&I input for the European economy and society. In pursuance of better trained PhDs, HR practices of hosting institutions will be developed and harmonized, and intersectoral collaboration will become regular. Furthermore mobility schemes at system level will develop and become part of everyday actions in research organizations.

Keywords: phd training,career development,genomics,neurosciences,cardiovascular diseases,metabolic diseases,translational research,interdiciplinarity,internationality,intersectorality,mobility
DEciphering mechanisms of presynaptic reFINEment (DEFINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-04-06
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synaptic restructuring from the perspective of the entire circuit and its modulation by experience during development may allow for improved therapeutic intervention in neurodevelopmental disorders.

Keywords: synapse,nmda receptor,axon,presynaptic,critical period,refinement,pruning,activity regulated,callosal projection neurons,somatosensory cortex
Pathways to Intrinsically Icephobic Surfaces (INTICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2020-10-31
Duration (months): 60.0
Total project cost (EUR): 2498043.0
EU funding (EUR): 2498043.0
Participants: 1
Project status: CLOSED

Icing of surfaces is common in nature and technology, affecting everyday life and often causing catastrophic events. Despite progress in recent years in the area of hydrophobicity, engineered surfaces that can be employed in applications based on their intrinsic icephobicity, going beyond classical additional chemical coatings or heating treatments, are not a reality. Understanding and counteracting surface icing brings with it significant scientific challenges, which form an intersection of nucleation thermodynamics, interfacial thermofluidics and surface nanoengineering/science. This project will investigate important mesoscale phenomena (a term used here to summarily describe phenomena manifesting themselves in the spatial range from the order of a nanometer to a hundred microns), which affect the behavior of water on surfaces with respect to icing. With the resulting, unifying knowledge base, the aim is to identify pathways for the design and fabrication of a new class of intrinsically icephobic surfaces, based on their a-priori engineered composition and texture. Our aim is to identify anti-nucleation and anti-wetting phenomena, leading to surfaces having long ice nucleation time scales, low water contact and retention, and low ice adhesion. The effects of surface texture curvature on ice nucleation, local liquid confinement on freezing point depression, and mesoscale texture features on interfacial thermofluidics, have intertwined and sometimes counteracting impacts on surface icing behavior, which we aim at unraveling, to determine pathways to high performance surfaces. Connected to all this is the employment of advanced surface texture fabrication and methods to perform the necessary experiments, lending consideration to the development of such surfaces for future applications. Beyond icephobicity, this research has clear implications to the characterization of mesoscale phase change phenomena, for multiphase heat and mass transfer processes and devices.

Keywords: thermodynamics,heat transfer,wetting,nanotechnology
Enhancing Engulfment of Apoptotic cells: basic biology to Therapy (EATing more)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses. We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts. Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic complexities of apoptotic cell clearance are just beginning to be deciphered, we anticipate that this study will also provide insight into molecular pathways of apoptotic cell uptake and processing.

Keywords: apoptotic cell clearance,boosting phagocytosis,efferocytosis,engulfment,functional drug screening,unbiased targeting,high throughput imaging
Deciphering the Molecular Mechanism of an Enzymatic Machinery for Glycogen Biosynthesis (DeciphGYG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-02
End date: 2024-05-01
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The biosynthesis of glycogen - glycogenesis - represents a key glucose (and hence energy) storage process across a wide range of organisms. Human glycogenin 1 (hGYG1) is one of the two primary enzymes that initiates the biosynthesis of glycogen, our energy reservoir. It polymerizes a maltosaccharide chain covalently attached to an enzyme residue, Y195, via a stepwise glycosylation reaction. In the reaction cycle, a dynamic conformational switch between ground and active states induced by one of the enzyme substrates, the sugar donor UDP-glucose, was predicted by structural studies, including a stretch of a critical loop containing Y195, the acceptor arm, and a major movement of a 32-residue lid covering the active site. The T83M mutation, which causes glycogen storage disease (GSD) type XV, makes the enzyme catalytically inactive. The scientific aim of DeciphGYG is to design a new protocol combining a series of both computational techniques (MD, QM/MM MetaD, HREX and BE-MetaD) and experimental results (NMR and crystallography) to unveil the mechanisms of glycogen biosynthesis, including both the glycosylation reaction as well as its coupling with the conformational changes induced by binding of the UDP-glucose donor and acceptor substrates. The experienced researcher (ER), Qinghua Liao will carry out the project in the University of Barcelona under the supervision of Prof. Carme Rovira, who has extensive experience in computational modeling of carbohydrate-active enzymes. Our goal will be shaping the understanding of hGYG1 action fully on glycogen biosynthesis, facilitating drug design against GSD type XV. Moreover, the new protocol will be transferable to other enzymes of interest in glycobiology. Altogether, the DeciphGYG project will allow the ER with a highly competitive multidisciplinary profile by complementing his previous acquired skills, placing him at a strong position to start his career as an independent and innovative principal investigator.

Keywords: glycosyltransferase,glycogenin,lid motions
Mobile Technology for Infant Social-Cognitive Neuroscience: Interdisciplinary Training Network for Innovative Infancy Research (MOTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Sweden,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3685396.13
EU funding (EUR): 3685396.13
Participants: 9
Project status: CLOSED

Recent international reports emphasize that the first three years of children’s life have more impact on their future outcomes than any other period during life. It is therefore essential that we have a thorough understanding of early social and cognitive development. In the past, experimental research that has fed our knowledge on early development studied infants within restricted, artificial laboratory contexts. However, only by studying children who are actively engaging in natural interaction with their social and physical environment, we can acquire ecologically valid, robust information about their social and cognitive development. It is thus essential to move experimental infancy research towards more natural situations. In doing so, MOTION will train a new generation of highly-skilled experts in the field of early development. New advances in wearable and wireless technologies now provide us with a unique opportunity. We are able to literally "unleash" the children we study – to free them from cables and constraints associated with the previous research methods. The primary scientific aim of the MOTION project thus is to leverage these new technological advances to study infants’ and toddlers’ body movements, gaze direction, and brain activity as they spontaneously and actively explore the world around them. MOTION will develop, produce and commercialize new tools to study early development in close cooperation between industry and academic partners. Innovative research tools will be used to investigate infants in natural interaction with their social and physical environment and gain a deeper understanding of early development. In addition to disseminating the new tools and research findings among the scientific community, it is the explicit aim of MOTION to reach out to professionals and the public, educate them about early development and instigate an open dialogue between professionals working with young children and developmental researchers.

Keywords: infancy,social cognitive development,ecological validity,novel experimental methods
A toxin-free, food-safe, autonomous mobile misting disinfection system that eradicates pathogens within 5 minutes and gives residual protection for 24 hours reducing the need for water and antibiotics (VIRIDIS MIST)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-07-01
End date: 2017-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Residual Barrier Technology Ltd. is an SME set up with the aim of developing disruptive, green sanitation products while delivering higher performance than state of the art solutions and thus achieve impact globally. Disinfectants are relied on as the last line of defense against ever-evolving bacteria and viruses – but due to current chemistry they come with inherent disadvantages including, toxic/mutagenic ingredient use and offers no residual protection. Methods application such as spraying, fogging and fumigation are time and labour intensive and provide inconsistent and incomplete coverage. We have developed VIRIDIS a patent pending non-toxic, non-mutagenic platform disinfectant that is a breakthrough in the fight to effectively eradicate bacterial pathogens, spoilage organisms, and viruses. However, VIRIDIS MIST does not stop there – once deposited on a surface the advanced micelles holding the active ingredients crystallise to create a protective residual barrier that has been independently proven to continue to kill bacteria for days even when dry - preventing them from rebuilding or mutating to form a resistance. We currently work with clients in the food processing and agriculture market to design and fit bespoke large scale residual misting systems for their facilities operating on a service charge model. However, there is a considerable expense and time involved in installing the network of fixed pipes and nozzles at their sites – making it cost prohibitive in small to medium sites and impossible to implement in haulage and shipping contexts. VIRIDIS MIST will service this much larger market micromedium scale market through the use of autonomous mobile apparatus. We are requesting funding for the development and production of 24 demonstrator application (8 x 3 different sizes) systems to gain customer confidence among our suppliers and end users.

Keywords: disinfectant,residual,protection,toxin,free,pathogen,antibiotics,safeguarding,water
Functional characterization of the cell division inhibitor MipZ (MIPZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-03
End date: 2018-04-09
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

Keywords: bacterial cell division,division site placement,ftsz polymerization inhibitor,para mind atpase family,caulobacter crescentus