Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Migration, religion and work in comparative perspective. Evangelical ‘ethnic churches’ in Southern Europe (MIGRANTCHRISTIANITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-06-11
Duration (months): 24.0
Total project cost (EUR): 160477.2
EU funding (EUR): 160477.2
Participants: 1
Project status: CLOSED

How do Evangelical migrants use religion and church-related networks to seek employment, pursue social mobility, construct respectability and resist racism? How do Evangelical churches become ‘brokers’ of socio-economic integration of their members thus stakeholders in immigration countries? These are the main questions that this project seeks to answer. MIGRANTCHRISTIANITY investigates how migrant men and women from Sub-Saharan Africa and Latin America make use of a minority religion in negotiating their social and economic integration in Europe. The project focuses on Ghanaian and Ecuadorian migrants in Italy and Spain. I investigate how migrants develop strategies of integration through the Evangelical churches and how such strategies are shaped by ethnicity, class, gender and age. I also look at how Evangelical churches act as ‘brokers’ of integration, in relation to employment but also with reference to a wider social positioning of the migrant as a ‘minority Christian’. In doing so, the research contributes to our understanding of the role of religion in migrants’ integration or marginalisation and of how migration is reconfiguring the Italian and Spanish societies through the production of new understandings of Christianity: these churches challenge the Catholic majority religion as well as dominant views of migrant religion as Islam only. The MIGRANTCHRISTIANITY project brings together two hitherto separate strands of research: that on migrant labour and ethnicity on the one hand, and that on migration and religion, more specifically on migration-driven Evangelical churches, on the other.

Keywords: migration,ethnicity,racism,work,gender,ethnic churches,religion,ecuadorians,ghanaians,italy,spain
OrganVision: Technology for real-time visualizing and modelling of fundamental process in living organoids towards new insights into organ-specific health, disease, and recovery (OrganVision)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Norway,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 3694188.75
EU funding (EUR): 3694188.75
Participants: 8
Project status: SIGNED

OrganVision is a revolutionary technology proposition that will break new grounds in microscopy and develop an ideal imaging solution for organoid research. It will enable life scientists to visualize life unfolding in real-time inside the cells and tissue in an organ-mimicking living tissue environment (called organoid here). It will alter the paradigm in microscopy by converting the central obstacle of light scattering by thick samples into the central opportunity that enables 3D label-free imaging on organoids in real-time with sub-cellular (~200 nm) and inter-cellular resolution (~1 um) at speeds of >1 volume per second (cube of 100 um). For achieving this unprecedented feat, OrganVision will develop a new multi-physics solver that solves transport of intensity (ToI) and full wave electromagnetic (FWEM) models in a coupled manner. ToI provides 3D image with inter-cellular resolution and generates intensity distribution inside the sample. FWEM uses this intensity distribution to decode the near-field light interaction between the sub-cellular entities for generating 3D sub-cellular image. A novel microscope instrument delivers custom designed 3D illumination patterns at the speed of 200 patterns per second in order to solve the problem of ill-posedness encountered by these solvers. In order to exploit the opportunity thus created, OrganVision will develop an a computational model that models the dynamics and interactions of functional entities recorded by OrganVision imaging solution in order to identify the underlying mechanisms. The proof-of-concept will be shown on engineered heart tissue for real-time imaging of cell and tissue activity towards studying injury, repair and regeneration in heart muscle. OrganVision will transform microscopy from a visualization device to a knowledge discovery tool that will change the course of organoid research forever. We believe that OrganVision will lead to better understanding and faster therapy for several diseases.

Keywords: label free microscopy,organoids,dynamics modeling,ultrafast real time high resolution imaging system,cardiovascular health
Synthetic viability of homologous recombination-deficient cancers (SYNVIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 1999437.5
EU funding (EUR): 1999437.5
Participants: 1
Project status: CLOSED

Although various effective anti-cancer drug treatments have become available over the last decades, drug resistance remains the major cause of death of cancer patients. Striking examples are patients with tumors that are defective in DNA repair by homologous recombination (HR). Despite initial responses to cancer therapy, resistance of primary or disseminated tumors eventually emerges, which minimizes therapeutic options and greatly reduces survival. The molecular mechanisms underlying this therapy escape are often poorly understood. In the SYNVIA project I will address the problem of therapy escape by using powerful genetically engineered mouse models for BRCA1- and BRCA2-deficient breast cancer, which closely mimic the human disease. Due to the BRCA inactivation, the tumors that arise lack HR-directed DNA repair. Similar to the situation in cancer patients, we observe that cancer cells in these models eventually escape the deadly effects of chemotherapy or novel targeted drugs. Thus, these resistance models provide a unique opportunity to explore therapy escape mechanisms. I propose an approach that will take the in vivo analysis of therapy resistance mechanisms to a new level. By synergizing the advantages of next generation sequencing with functional genetic screens in tractable model systems, I will explore novel mechanisms that cause resistance of HR-deficient cancers by the loss of another gene (“synthetic viability”). I provide evidence that new mechanisms of resistance can be identified with this approach. In an innovative step, I will generate genome-wide alterations using the revolutionizing CRISPR/Cas technology. Mutations will also be introduced into 3D tumor organoid cultures, as we found that these are more physiologically relevant. I am convinced that the combination of these state-of-the-art approaches will yield highly useful information for designing effective approaches to circumvent or reverse therapy escape in human cancer patients.

Keywords: brca1,breast cancer,anti cancer drug resistance,dna repair,crispr,genomic screens,3d organoid cultures
Artificial Intelligence and Big Data CSA for Process Industry Users, Business Development and Exploitation (AI-CUBE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Coordination and support actions
Countries involved: Spain,Germany,Italy,Spain
Call: Artificial Intelligence and Big Data Technologies for Process Industries (CSA) (H2020-NMBP-ST-IND-2020-singlestage, 2020)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 597806.25
EU funding (EUR): 597806.25
Participants: 5
Project status: CLOSED

AI-CUBE seeks to enhance the understanding of different digital technologies related to artificial intelligence (AI) and big data (BD) applied in process industries for all the SPIRE industrial sectors. At the start of the project in September 2020 there were eight SPIRE industrial sectors considered, namely: cement, ceramics, chemicals, engineering, minerals and ores, non-ferrous metals, steel and water. At the start of 2021, also pulp & paper and refineries were added – which were then considered and integrated into the list of sectors being analysed through the project. Therefore, a close collaboration with industry is mandatory to achieve in-depth insights into possible application areas of AI for processes, technology, sensor applicability and assessment of their level of penetration. The overall project approach is based on the development of a 3-dimensional conceptual matrix based on: 1) AI and BD technologies 2) Application areas (activities and industrial processes) 3) SPIRE sectors AI-CUBE’s main goal is to define a roadmap in AI and the use of BD for the process industry and their maturity level across the industrial sectors, including guidelines for implementation. Industrial stakeholders and associations will validate the consolidated roadmap ensuring solution feasibility and benefits for the European industrial community. A crosslinked vision over process industry sectors shall facilitate cooperation and boost technologies deployment at their full potential. An in-depth consultation with industry (association, representatives, companies) will provide an overview of current AI and BD algorithms application, identifying exploitable synergies among sectors. A deep study of the application areas in planning and operations within other industrial sectors facilitates a gap analysis, propitiating knowledge sharing among processes and sectors. A Multi-Actor Multi-Criteria analysis will obtain a widely supported and consensus-based action plan for industrial consultation. This will allow the inclusion of a broad stakeholder community representing the main industry actors throughout all the SPIRE sectors, with which the project consortium has strong connections that will support sector integration and stakeholders’ engagement.
Host-microbe interactions involving microbial dark matter: Biology and evolution of a ubiquitous group of intracellular bacteria. (Hidden life)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

The kingdom Bacteria represents the most widespread and diverse life form on Earth. On the 89 recognized bacteria phyla, 60 lack a cultivable representative, being thus considered as candidate phyla, or “microbial dark matter” (MDM). Accumulating evidence suggests that a substantial fraction of these elusive microbes is associated with (eukaryotic) hosts. The candidate phylum TM6 represents a major MDM phylum; its members are globally widespread and frequently detected in natural and man-made environments. The draft genome sequence of an uncultivated TM6 member suggested a potential symbiotic lifestyle with protist hosts. This was recently confirmed with the first TM6 isolate obtained by co-cultivation with amoebae. In line with these observations, I recently isolated and cultivated a free-living amoeba species naturally harbouring TM6 bacteria as endosymbionts, making it the first TM6 bacterium isolated with its natural host, and the second worldwide to be cultivated in laboratory conditions. While members of the TM6 phylum are ubiquitous and thought to be involved in major biological processes, their ecology and biology remain at this time unexplored. Through the use of state-of-the-art genomics, bioinformatics, super resolution microscopy, proteomics and innovative metatranscriptomics approaches, I aim to uncover the ecology and biology of TM6 bacteria. The proposed research, facilitated by my ability to cultivate TM6 bacteria within their natural hosts in laboratory conditions, is relevant and urgently needed, because i) it will improve our general understanding of MDM’s poorly known ecology, and ii) it will help uncover the lifestyle of a ubiquitous group of intracellular microbes, their strategies to infect and thrive within eukaryotic hosts. Carrying out this project will undoubtedly place me in an excellent position to develop a successful and top-level career in the field of host-microbe interactions and symbioses.

Keywords: microbe host interactions,protists,microbial dark matter
verv: advanced home electricity analytics (verv)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Founded in 2009, Green Running are a fast growth EU SME working with a range of key electricity sector partners (Centrica, UK Power Networks). Having already established a portfolio of commercial and industrial sector electricity analytics tools, in 2014 Green Running began development of a domestic solution -verv. Verv applies patented machine learning algorithms to detect and profile all sources of electrical activity (generation, storage and consumption) active on a household's electrical system. Generating real time, itemised (iappliance level), usage data across metrics such as energy (kWh), cost (€), environmental impact (tCO2) and power quality (Hz) - verv generates valuable outputs for electricity retailers to customise/extend their services. With continental Europe subject to many of the same drivers, and several of Green Running's target customers (electricity retailers) active in multiple EU markets, Green Running now seek a H2020 Phase 1 feasibility study to validate verv's pan-European commercial and technical potential. A 5 month project including market study, proposition refinement, partner engagement, IP strategy management, technology road map updating for multi-market operation and risk management will provide Green Running with the comprehensive knowledge, and partners it requires to first undertake a follow on multi-market field trial, and then launch verv in non-UK markets by 2020. Current projections suggest doing so can boost verv's customer acquisitions by 200%, generate annual revenues of >€6m by 2022 and an operating EBIT of €1.7m supporting creation of 38 new jobs, 23 of which will be high skilled positions at Green Running. >30,000tCO2 are also forecast to be avoided, making a valuable contribution to EU decarbonisation. This Phase 1 study will accelerate and extend the growth of a high potential EU SME, allowing it to establish Europe's presence in the cutting edge innovation fields of artificial intelligence, and data analytics.

Keywords: electricity disaggregation,machine learning,big data
Towards Optimized Use of Research Reactors in Europe (TOURR)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Action type: Coordination and support actions
Countries involved: Germany,Spain,Belgium,Hungary,Poland,Slovenia,Czechia,Czechia
Call: Optimised use of European research reactors (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 1095660.0
EU funding (EUR): 1095660.0
Participants: 9
Project status: SIGNED

Nuclear research reactors (RR) have been constructed in countries implementing nuclear power plants and used in experiments necessary to develop commercial reactors and training programmes. Neutron irradiations have found new applications in the adaption and production of existing and new materials, including medical radioisotopes. The latter enabled development of new diagnosis and treatment techniques, for the benefit of millions of patients. Europe has a broad and very diverse landscape of RRs, many of them 30-50 years in operation, well maintained and regularly upgraded. Yet financial pressure, caused by combination of declining interest and the absence of a sound financial model, led to closure of many of them ( e.g OSIRIS in Saclay) and a few others will close soon (e.g. BER2 in Berlin). On the other hand, only one RR is now being constructed – the Jules Horowitz Reactor. Those negative trends call for a coordinated European action to assess the impact of the decreasing number of RRs, identify future needs (including new neutron sources), draw a roadmap for upgrade of the existing RR fleet, and a model for harmonized resource management. TOURR project is a response to this challenge. Its primary objective is to develop a strategy for RR in Europe and prepare the ground for its implementation. This strategic goal can be divided into specific objectives: (1) Assessment of the current status of European RR fleet, including plans for upgrade; (2) Evaluation of urgent EU needs; (3) Developing tools for optimal use of RR fleet, (4) Rising awareness among decision makers on the (future) role of RRs. The ambition of TOURR project is to secure access and availability of RRs as a vital part of the European Research Area and to support stable supply of medical radioisotopes.

Keywords: research reactors,training reactors,medical radioisotope supply
THE SUSTAINABLE MOBILITY PLANNER (SMP) (SMP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Sustainable Mobility Planner (SMP) is a specialized innovative IT software (tool) that enables environmental, financial and social impact assessments of sustainable transport initiatives taken in an urban environment. The tool integrates methods and calculations of the benefits of creating environmental zones, using low emission vehicles for urban distribution, bundling of goods, night distribution, reducing road capacity, etc. In short, all schemes, which municipalities, individually or together with the transport and logistics industry and retailers, can implement in urban areas to optimize freight activities and increase focus on sustainable freight transportation initiatives. The SMP interconnects emission calculations and small scale traffic models with visual communication in one system tool. The tool's usefulness and ease of use is ensured through constant updates with the latest available data from NTU’s portfolio of projects, as well as through user-based data inputs and feedback. The business model guarantees a continuous development and upgrading of the tool, which will be based on the latest available transport and environmental data. The reliability will, compared to existing tools, set new standards, by replacing estimates with concrete and updated data, which is added to the system via the backend solution. SMP will: - On a continuous basis be able to monitor progress, calculate environmental improvements and assess the potential and need for new investment in the urban transport initiatives. - Give politicians and planners the opportunity to compare environmental impacts of different transportation alternatives. - Be a useful decision support tools with high and multifaceted functionality for transport solutions and the associated political framework.

Keywords: eco efficient decision support tool for planning of sustainable freight transport initiatives in an urban environment
NATURE FRIENDLY WATER HYDRAULIC STEERING SYSTEM (GREEN WHS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovenia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A vast majority of the sailing boats currently sailing the world’s seas are being steered with a complex mechanical steering system. A great disadvantage is in the complexity of the currently standard built-in mechanical steering systems with steelwiring, intertwined with chains and transfers that is hidden in the boat’s hull that connect the steering wheel and the rudder. Hydraulic steering/operating systems are currently used in a wide range of motor-operated vessels, whereas for sailing boats such steering systems are not available on the market. The greatest challenge of all hydraulic steering systems is in motor-operated vessels is environmental - hydraulic oil leakage. Namely, 1 drop of hydraulic oil damages 150 l of drinking water and the cleaning of 1000kg of polluted soil costs around 2.000€. With the GREEN WHS steering system hydraulic oil leakage is impossible, since the hydraulic medium in our case is water. GREEN WHS also addresses the environmental issue of ‘dumpster marinas’, where old abandoned sailing boats decompose and burden water ecosystems many years; only in Spain the communities are dealing with more than 10.000 such vessels (https://bit.ly/2MiypXb). There are no currently known hydraulic steering system solutions for sailing boats available on the market. Currently available steering systems on the market are based on mechanic principles. We see our business opportunity in offering the market an advanced water hydraulic steering system for sailing boats that convinces the sailing boat manufacturers and buyers by its simplicity in terms of installation and maintenance requirements. We plan our initial market entry through the existing base of buyers – sailing boat manufacturers, OEMs and B2B business partners. We are already in constant contact with all of them online and in face-to-face meetings. The market share at the initial market take up we are aiming at is between 0,5% and 1% of the total boat steering market in the EU.

Keywords: sailing boat,water hydraulic steering system,green,environmentally friendly,recyclable,degradable