Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative pulse and cereal-based food fermentations for human health and sustainable diets (HealthFerm)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Belgium,Sweden,Finland,France,Switzerland,Denmark,Germany,Italy,Romania,Austria,Netherlands
Call: Microbes for healthy and sustainable food and diets (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 11303944.75
EU funding (EUR): 11303944.75
Participants: 23
Project status: SIGNED

Food fermentation has been used for millennia, but our knowledge on the impact of fermented foods on human health and the possible role of gut microbiota in it is limited. Microbial consortia and fermentation processes are, hence, not designed for optimal health outcomes. At the same time, fermentation technology represents a major opportunity to increase incorporation of plant-based proteins in diets. The multi-actor consortium HealthFerm brings together first-class researchers, food companies and dissemination partners to enable the transition from traditional to sustainable grain-based fermented foods and diets that deliver health benefits to consumers by design. This will be achieved by (1) disentangling the interaction between food fermentation microbiomes, grain-based foods and the human gut microbiome and health and (2) using microbial resources and fermentation technology to develop healthy pulse and cereal-based food and diets that cater to the desires and needs of EU citizens. Drawing from a community science approach, HealthFerm will identify micro-organisms and metabolic pathways that may result in desired nutritional and health effects. The impact of microbial fermentation on raw materials will be examined at the molecular level. Fermentation technology will be used in the production of grain-based liquid and (semi-)solid foods. The impact of these foods on human health and the gut microbiome will be assessed in a number of intervention trials. Consumer acceptance of fermented foods, their technologies and their role in the transition towards a more sustainable healthy diet will be studied in different social contexts. Finally, extensive ecosystem building and training activities will contribute to HealthFerm’s strong participatory approach. Outcomes will allow increased use of grain-based materials in foods, contributing to an environment-friendly food system and a strong EU food industry, thus aligning with the EU Green Deal priorities and UN SDGs.

Keywords: food fermentation,microbiome,grains,cereals,legumes,plant based,protein,human gut microbiome
European Bench for Engine and Stage Testing (Eu-BEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Spain,Ireland
Call: Modern, flexible and efficient European test, production and launch facilities (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 4959190.0
EU funding (EUR): 4959190.0
Participants: 7
Project status: SIGNED

In 2030, there will be several private small launchers in activity in Europe, with a higher launch rate than A6 and Vega C. 99.99% of the launcher life is spent on the ground, the flight period is a tiny part of his life. With launcher reusability the major factor of cost for space transportation will be the ground segment CAPEX and OPEX. Among ground activities, there will be hundreds of engines and stages tests per year, covering all the launcher life cycle phases : qualification, production, reuse. Our consortium think there is a place for a new business model where standardized ground segment services are sold to launchers, in place of letting them invest and operate their own specific facilities, which represent a high cost. To do so, we propose to work on two main axis: horizontality and verticality. Horizontally means that our solutions allow, for a given launcher, to have equivalent user experiences and services for all life cycle needs, thanks to mobile and modular ground means. Vertical interoperability means that our solutions allow, for a given location and life phase, to propose an equivalent experience and service for different launchers. Several such interoperable facilities may be exploited across Europe and even worldwide. Europe is then capable to become a leader of interoperability implementation, it is of prime importance for future space exploration and exploitation where interoperability is a key. The Eu-BEST will be used to - test rocket engines from different manufacturers - test rocket stages from different manufacturers The targeted performances are: - up to 500kN -200 tests per year - 25k€ per test Such engine testing facility doesn’t exist in the world. It will significantly strengthen European space transportation capabilities and put Europe at the forefront of ground technologies for launchers. To achieve those functional and performances targets, Eu-BEST concept relies on interoperability, modularity, and virtual commissioning.

Keywords: launcher engine and stage testing interoperable mobile modular
Advanced Packaging and Heterogeneous Integration for Electronic Components and Systems Pilot Line (APECS-PL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Germany,Austria,Finland,Belgium,France,Greece,Spain,Portugal
Call: Pilot line on advanced Packaging and Heterogenous Integration (HORIZON-JU-Chips-2023-RIA-CPL, 2023)
Start date: 2024-11-01
End date: 2029-06-30
Duration (months): 56.0
Total project cost (EUR): 194423096.69
EU funding (EUR): 96211548.36
Participants: 10
Project status: SIGNED

As a contribution to the EU Chips Act, the Research Fab Microelectronics Germany (FMD) proposes an Advanced Packaging and Heterogeneous Integration for Electronic Components and Systems Pilot Line (APECS-PL), which combines the generation of globally competitive high technology that addresses the specific needs of German and European industry and enables a low-threshold, easily scalable industrial transfer. The APECS-PL will include novel characterization, quality assurance, testing & reliability methodologies, test methods to assess the security of microelectronic systems against physical attacks and a System Technology Co Optimization (STCO) framework. Together with the 2 nm GAA (imec), 5 nm FDSOI (Leti) and wide bandgap semiconductor pilot lines also planned within the EU Chips Act, the APECS-PL is also in a position to become an essential component on the way to the vision of a pan-European pilot line facility - and thus an indispensable pillar for achieving the EU Chips Act target of bringing 20% of the global supply of chip production back to Europe. In addition, APECS-PL offers a one-stop shop for a very broad international customer base in basically all classic vertical industrial sectors including large companies, SMEs and technology start-ups. Demonstrators are planned to evaluate how the elements of the pilot line work together. The FMD-OFC office, managed by Fraunhofer as legal entity, is responsible for operational management. As a first step for additional European R&D partners the project partners imec, Leti, VTT, IMB-CNM (CSIC), INL, Forth and TU Graz will be included. The shortage of skilled workers and scientists is of particular interest in the project. Better integration of a gender dimension into research and innovation content will be an essential part of the project. Systematic eco-design that generally minimizes energy and resource consumption is in line with the EU Green Deal.

Keywords: fmd,apecs pl,pilot line,advanced packaging and heterogeneous integration,fraunhofer,eu chips act,microelectronics,stco,gaa,fdsoi,eu green deal,security,characterization,randd,chips,chiplet
Smart MAterial System to enHance the service life of reinforced concrete structures (SMASH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-16
End date: 2026-09-15
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Sustainable development is one of the main challenges that humanity has to face to progress. The construction industry strongly influences the achievement of this goal, as it heavily impacts on resource and energy consumption, waste production, greenhouse gas emission. The extension of the service life of structures will be one of the measures necessary for this sector to support sustainable development, since it can save resources, decrease the carbon footprint and reduce waste production. Reinforced concrete structures (RCS) represent the vast majority of the built environment, so research efforts should be focused especially on this type of structures. One of the most promising approaches to prolong the service-life of RCS is the development and implementation of Smart Structures, being structures able to sense some external stimuli, process the information and respond autonomously in real time by using smart materials technologies. Research on this topic is advancing, but it is still a challenge to achieve efficient systems. The final goal of SMASH is precisely to develop an efficient “Smart Material” system to be implemented in RCS in order to enhance their service life, on the way to sustainable development. The key enabling technologies to develop this system will be capsule-based self-healing and voltammetric sensors, combined together to produce a synergic effect. With the support of my supervisor (Prof. Paola Antonaci) and her extensive knowledge in the development and characterization methods for innovative building materials, the fellowship will train me in the frontier fields of self-healing and advanced repair technologies, complementing my expertise on sensor systems. Ultimately, SMASH will provide a crucial contribution to relevant research on the reduction of the environmental impact of the construction sector, and on the advancement of smart materials to achieve smart structures, in order to reach SDG 11 (Sustainable cities and communities).
Nanoscintillators to potentiate brain cancer radiotherapy: from physics to preclinical trials (RADIANCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1948125.0
EU funding (EUR): 1948125.0
Participants: 1
Project status: SIGNED

More than 50% of cancer patients undergo radiation therapy (RT) in the course of their treatment. However, because of a lack of specificity for tumor tissues, delivering therapeutically effective doses of X rays with tolerable toxicity on healthy tissues remains a challenge. Glioblastoma multiforme (GBM), the most common primary brain cancer in adults has a dismal prognosis despite an aggressive standard-of-care. Developing new strategies to improve the therapeutic index of RT is therefore of major importance. The aim of this project is to comprehensively study the multifaceted radiotherapeutic effect of nanoscintillators (NS), and determine how to harness these effects to improve the therapeutic index of RT. By converting high-energy photons such as X-rays into UV/visible photons, NS can augment RT by various effects. These include radiation dose enhancement, radioluminescence-induced photodynamic therapy and DNA damage generated by UV-radioluminescence. This project has three main objectives: 1) To elucidate the physical and photochemical origins of the radiotherapeutic effects of NS using spectroscopic studies to identify the reactive oxygen species and DNA lesions generated upon X-rays; 2) To study the biological impact of the NS on 3D models and in syngeneic rat models of GBM; 3) To develop an in silico program that simulates the efficacy of prospective NS, and studies the impact of their composition, size and morphology. This will tailor future NS to specific malignancies with distinct biological properties. With this innovative methodology and an interdisciplinary approach that ranges from physics to biology, this project will provide ground-breaking fundamental knowledge on the radiotherapeutic effects of NS that may lead to highly valuable and clinically translatable therapies. In the long-term, this strategy may be tailored for pancreatic and metastatic ovarian cancers, for which the multifaceted enhancement of RT efficacy by NS may be of great interest.

Keywords: nanoscintillators,radiotherapy,photodynamic therapy,radiation dose enhancement,glioblastoma
The Wool Age: rethinking social life in later prehistoric Europe (WOOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

The story of European prehistory is written in durable materials – stone, bronze and iron define the major archaeological periods and are taken to have shaped corresponding societies. Perishable materials, such as wool, have comparatively little impact on our understandings. However, wool production is highly demanding on societal and economic organisation and produces its own embodied experiences through seasonal production cycles. The earliest domesticated sheep had a hairy fleece, unsuitable for spinning into yarn, so the arrival of wool-bearing sheep fundamentally reorganised pastoral life: requiring novel husbandry practices (plucking/gathering shed wool, castration to increase quality, etc.) and huge investment in yarn/textile production. Its adoption in Bronze Age Europe has even been termed a ‘revolution’ (Sabatini & Bergerbrant 2020), bringing a new material with unique insulating properties, new ways of expressing identities, and new forms of human/animal interaction. Critically, the timing of this process appears to be uneven. The earliest evidence for wool in Britain is the Rylstone textile, dated to 840–590 BC, while Danish examples, for instance, occur from 1700 BC. This is curious given a known rise in sheep numbers in Southern England throughout the second millennium BC. Could wool really be absent from Britain while revolutionising Europe? ‘The Wool Age’ will define the emergence and growth of the prehistoric wool economy in Britain for the first time and characterise the societal consequences. This will be achieved through a novel triangulation of available evidence (animal bone reports, textile tools, and landscape organisation) which avoids waiting for the chance survival of delicate textiles. Thus, a critical issue to our understanding of societal organisation and European interconnection can be revealed.

Keywords: human animal relations,textiles,bronze age europe,wool,sheep
All Data 4 Green Deal - An Integrated, FAIR Approach for the Common European Data Space (AD4GD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Spain,Switzerland,United Kingdom,Belgium,Germany,Poland,Luxembourg,Hungary
Call: Common European Green Deal data space to provide more accessible and exploitable environmental observation data in support of the European Green Deal priority actions (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4364196.25
EU funding (EUR): 4136964.75
Participants: 13
Project status: SIGNED

AD4GD’s overall objective is to co-create and shape the European Green Deal Data Space as an open hub for FAIR data and standards-based services that support the key priorities of biodiversity, climate change, and pollution. The focus will be on interoperability concepts that bridge the semantic and technology gaps which currently prevent stakeholders and application domains from multi-disciplinary and multi-scale access to data, and which impede the exploitation of processing services, and processing platforms at different levels including Cloud, HPC and edge computing. This project will enable the combination and integration of data from remote sensing, established Virtual Research Environments and Research Infrastructures, Internet of Things (IoT), socio-economic data, INSPIRE and Citizen Science (CitSci) in an interoperable, scalable and reliable manner. This will facilitate integration by including semantic mappings to different standards and dominant models bridging domain- and data source-specific semantic concepts such as the Essential Variables framework (e.g. the GCOS Essential Climate Variables, the GEOBON Essential Biodiversity Variables), as well as applying machine learning and geospatial user feedback to ensure quality, reliability and trustworthiness of data and transforming spatial scales. The project will make data and services accessible to the EC Knowledge Centres, GEOSS portal, EOSC and other science services as applicable, ensuring the sustainability of the results, and will actively promote data accessibility for community stakeholders and citizen scientists. AD4GD will demonstrate and validate the approach in three pilots whose stakeholders include international organizations, scientists and researchers, citizens, decision makers (e.g. public authorities), and Earth observation (EO) solution developers. The pilots address selected Green Deal priority areas, including cross-domain components: Zero pollution, Biodiversity, and Climate Change.

Keywords: essential variables,biodiversity,zero pollution,climate change,interoperability,semantics,citizen science,iot,data integration,data quality,machine learning
Transitioning Psychotropic Alkaloids From Plants And Mushrooms To Neuroprotective Agents: Incorporating Computational Tools For The Development Of Novel Therapeutics (NEUROHEALTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Greece,Cyprus,France,Portugal,Spain,Bulgaria,Poland
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 2035491.43
EU funding (EUR): 1803600.0
Participants: 10
Project status: SIGNED

The NeuroHEALTH project aims to address the growing challenge of neurodegenerative diseases, such as Alzheimer's and Parkinson's, which affect millions worldwide and impose significant social and economic burdens. The project will harness the potential of neglected natural products (NPs), like alkaloids, from psychotropic plants and mushrooms that till recently had regulatory constrains. The integration of state of the art phytochemical analysis, with advanced computational tools will accelerate the discovery of novel NPs. In vitro and in vivo testing assays including zebrafish models will evaluate the safety and efficacy to reveal compounds of interest, that can enhance cognitive health and improve quality of life. Bioactive extracts and NPs will be scaled up and formulated in combination with a market analysis, sustainability and intellectual properties assessment will ensure that findings are relevant and applicable. Through strategic secondments and staff exchanges among academic and industry partners, NeuroHEALTH will foster interdisciplinary collaboration, enhancing knowledge transfer and innovation. Workshops, conferences, and outreach activities will engage diverse stakeholders, including professionals, policymakers, and the general public, promoting awareness of the project's findings and their implications for health care. By bridging the gap between traditional knowledge and modern science, NeuroHEALTH aims to deliver impactful solutions for neurodegenerative diseases, ultimately contributing to healthier aging populations. This timely initiative not only addresses urgent societal needs but also positions Europe at the forefront of innovative research in natural product-based therapeutics.

Keywords: natural product chemistry,chromatography,bioinformatics,metabolomics,neurogenerative diseases