Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap (ARISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Belgium,Netherlands,United Kingdom
Call: Clinical research on regenerative medicine (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2019-03-31
Duration (months): 51.0
Total project cost (EUR): 4954992.25
EU funding (EUR): 4954992.0
Participants: 10
Project status: CLOSED

65,000 aortic valve replacements (AVR) are performed in Europe each year to treat acquired and congenital aortic valve diseases. In affected patients, mortality without AVR is extremely high and 50 % die within 2 years. Current AVR options are, however, limited for young patients - especially female patients - and those unwilling to accept life-long medical anticoagulation with its inherent risks. None of the currently available prostheses for AVR is tailored toward the individual patient or allows for individual regeneration. The ARISE project will bridge this therapeutic gap in a Phase II clinical study to determine the feasibility, safety and efficacy of regenerative heart valves for aortic valve replacement. After extensive preclinical work, Haverich et al. have used decellularized allogenic heart valve matrices for AVR on the basis of compassionate use in 34 patients with tentative assessment showing auspicious initial clinical results. However, transferring this regenerative approach to routine clinical application necessitates controlled prospective clinical trials which are lacking to date. The translation of research in regenerative medicine from bench to bedside is frequently hampered by lengthy and complex regulatory procedures. This holds especially true for regenerative solutions based on human cell or tissue products where regulatory paths at national level are often unclear. Making these products available across Europe adds a further level of complexity as regenerative products are not subject to harmonized procedures, such as those for pharmaceutical products within Europe. The ARISE consortium will address these challenges, integrating a network of six leading centres for cardio-thoracic surgery, each with proven track records in clinical research, an innovative SME experienced in bringing human tissue products to the clinic and market and expertise in ethical and regulatory aspects of regenerative medicine. .

Keywords: heart valve replacement,tissue engineering,decellularization,regeneration by recellularization
TrafficFlow - Analytics for Smarter Cities (TrafficFlow)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TrafficFlow is an innovative, flexible and low-cost platform for road-traffic data collection and analysis. Using camera sensors, advanced computer vision software and web and mobile devices, TrafficFlow is THE cost-effective, high performing answer to our smart cities’ need for low cost, minimally invasive data management systems to improve urban transport management. TrafficFlow is a product for local authorities, professionals and companies operating in the smart cities field, all of whom require low cost, high performing solutions to gather large quantities of traffic data. This data is used to manage traffic, thus mitigating some of the negative economic and socio-environmental impacts of urban road mobility. The product will be launched on a primary, high-volume market that shows significant growth potential. The demand for Intelligent Transport Systems is growing all the time. In 2013, Europe accounted for 35.3% of global ITS revenue. This is expected to grow by 28.6% from 2015 to 2020. TrafficFlow is a unique product, whose characteristics in terms of quality, performance, services and costs far outweigh competitors using other monitoring techniques and those using video image processing. Operating in collaboration with key stakeholders from research and industry, Magenta has invested significant resources in development phases. The project presented as a phase 1 SME Instrument is focused on commercial, marketing and economic activities required for market entry, including the development of an IP strategy that protects this innovation. The feasibility assessment will lead to a full scale business plan. TrafficFlow will bring significant growth to Magenta (expected employment increase from 17 people in 2017 to 65 in 2021; expected sales over7M€ in 2021). It will bring economic and environmental benefits to EU transport players, with low impact and efficient traffic data analytics.

Keywords: traffic monitoring and management,data analytics,video image processing,intelligent transport systems,smart cities
Structured ACCREtion Disks: initial conditions for planet formation in the time domain (SACCRED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Hungary
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1370200.0
EU funding (EUR): 1370200.0
Participants: 1
Project status: SIGNED

In this ERC Starting Grant, I propose an ambitious research program to target important challenges in predicting realistic initial conditions for the planet formation process. I will perform a large systematic study of the accretion-driven eruptions of newborn stars, and evaluate their influence on the structure, composition, and chemistry of the terrestrial planet forming zone in the circumstellar disk. The research will focus on three main questions: - How does the mass accretion proceed in realistic, structured, non-axisymmetric disks? - What physical mechanisms explain the accretion-driven eruptions? - What is the effect of the eruptions on the disk? My new research group will study young eruptive stars, pre-main sequence objects prone to episodes of extremely powerful accretion-driven outbursts, and combine new observations, state-of-the-art numerical modelling, and information from the literature. With a novel concept, we will first model the time-dependence of mass accretion in circumstellar disks, taking into account the latest observational results on inhomogeneous disk structure, and determine what fraction of young stellar objects is susceptible to high mass accretion peaks. Next, we will revise the paradigm of the eruptive phenomenon, compelled by recently discovered young eruptive stars whose outbursts are inconsistent with current outburst theories. Finally, we will determine the impact of accretion-driven eruptions on the disk, by considering the increased external irradiation, internal accretion heating, and stellar winds. With my experience and track record, I am in a position to comprehensively synthesize existing and newly acquired information to reach the proposed goals. The expected outcome of the ERC project is a conclusive demonstration of the ubiquity and profound impact of episodic accretion on disk structure, providing the initial physical conditions for disk evolution and planet formation models.

Keywords: circumstellar matter,mass accretion,protoplanetary disks
Brain-environment synchrony and the auditory perception problem (BRAINSYNC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Synchronization of brain rhythms to the rhythms of sounds is a foundational mechanism for auditory perception. However, we know very little about why brain–environment synchrony might fail, leading to auditory perception problems like impaired speech comprehension that negatively impact quality of life. The proposed research program fills this knowledge gap in three stages: 1) Predicting auditory perception, and individual differences thereof, from the fit between neural dynamics and environment; 2) Perturbing the relationship between brain and environment to experimentally test the limits of and protective factors for brain–environment synchronization; 3) Translating gained knowledge to understand age-related dysfunctions in brain–environment synchrony and auditory perception. Stage 1 uses behavioural and neural properties of neural oscillators – brain regions and networks that generate rhythmic neural activity – to predict individual differences in brain–environment synchronization. Stage 2 assesses when and why auditory perception fails, and how auditory perception might be insulated by good brain–environment fit and neural flexibility, by challenging the brain’s ability to adapt to auditory rhythms. Stage 2 has strong potential to provide insight into compensatory listening strategies that may be adopted when neural entrainment is effortful or impossible. Stage 3 places special emphasis on listening difficulties that develop with age, and tests the hypotheses that 1) speech comprehension difficulties stem from reduced neural entrainment in older age, and 2) reduced entrainment for older adults results from age-related changes to neural flexibility. Noninvasive brain stimulation will be used to temporarily remedy these deficits by improving brain–environment synchrony. The research program will account for much currently unexplained individual variance in auditory perception, and will inspire novel interventions to support auditory perception in advancing age.

Keywords: neural oscillations,neural entrainment,auditory perception,rhythm perception
ISTplus - Postdoctoral Fellowships (ISTplus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 9180400.0
EU funding (EUR): 4590200.0
Participants: 1
Project status: SIGNED

ISTplus offers two-year fellowships for highly qualified, incoming postdocs fulfilling the mobility criterion, who will have the chance to join our world-class research teams in the fields of Biology, Neuroscience, Mathematics, Physics, and Computer science at IST Austria. The fellows will be integrated in a truly interdisciplinary research environment, interacting closely with colleagues from different fields (through shared facilities, joint projects, and events). The international dimension will be ensured by the multinational teams (with employees from more than 50 countries) and through international networking. An open, bottom-up international recruiting process will ensure scientific quality and potential of the selected ISTplus fellows. Already at the beginning of their stay, fellows together with a Career Counselor will assess their professional profile and skill set, define the direction of their future career path (be it academic or non-academic) and elaborate a development plan, supported by our Targeted Competence Building Program. A co-supervision scheme will support the fellows during their stay, meant to oversee scientific progress, but also to give advice regards individual career planning. A secondment scheme should kick-start and facilitate cross-boundary networking and translational research with an intersectorial network of excellent partners, incl. SMEs, applied research companies, organizations in the field of tech transfer and science education, and commercial enterprises. Fellows will be supported in the choice of the right partner, in setting up a research plan, and may opt for an extension of the fellowship for up to six months to enable intersectoral mobility. Various events, workshops, trainings, and further activities in the area of tech transfer will cultivate an open-minded entrepreneurial spirit among program participants.

Keywords: excellent science,career development,technology transfer
The initial 244Pu abundance of the Solar System (IPUSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 146239.2
EU funding (EUR): 146239.2
Participants: 1
Project status: CLOSED

The proposed project is a crossroad of noble gas cosmochemistry, geochemical modelling and astrophysics. We will obtain a best estimate of the initial 244 Plutonium content of the Solar System at the time when the first condensed mineral assemblages formed in the hot solar nebula. We will apply this value to model the volatile depletion history of the silicate Earth and to produce the first self-consistent estimate on the timing of the last addition of matter produced in rapid neutron capture processes (r process) to the Solar System. 244 Pu is an r-process- only short lived radionuclide that goes through spontaneous fission to produce Xenon isotopes and in principle the 244 Pu-Xe system can be used as chronometer to date early volatile loss events in Solar System solids. We propose a comprehensive experimental approach to study noble gases in combination with Nd (similarly volatile to Pu) and U (more volatile than Pu) abundances on a complementary set of samples that is adequate to explain the possible variation in the initial Pu/U ratio in different meteorites and early condensed mineral assemblages and to evaluate the applicability of the chronometer. While the Experienced Researcher is an expert in noble gas geochemistry and has experience in geochemical modelling, she will gain the knowledge on cosmochemistry and stellar nucleosynthesis required to interpret and discuss the new results produced in this project. The individual fellowship will help her start her early career as a postdoc and provide a crucial mobility to build a network in Europe and do research with high impact.

Keywords: noble gas cosmochemistry,chronometry,volatile depletion
Orphic Lithika : A New Edition (Or.Li.N.E.)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-09-05
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

The Orphic Lithika constitute a short poem in hexameters (774 lines) about the miraculous virtues of 29 stones, the author and the date of composition of which remain unknown. The aim of my research is to provide an overall study of this relatively poorly studied text, which is still lacking today: a reliable critical text, a faithful translation of the poem accessible even to non-classicists, and an extensive historical-literary and philosophical commentary which sheds light on the exact significance of a little-known text and its context of production. The methodology and approach that I will implement for the constitution of the text, the translation and the commentary will be traditional. The most innovative aspect of my work will consist in the attempt to propose a new comprehensive interpretation of the poem, starting from the hypothesis of its composition at the end of the 4th century AD within the milieu of the pagan philosophers who were friends and followers of the emperor Julian (361-363) – also known as “the Apostate” due to his failed attempt to restore pagan religious traditions in a Roman Empire which, by his times, had largely become Christianized. This project will enhance my creative and innovative scholarly potential and enable me to diversify my individual competence in terms of new skills acquisition, thanks to advanced training and international mobility. This would by in full conformity to the spirit and mission of the Marie Curie actions.

Keywords: late antiquity,byzantine studies,emperor julian,neoplatonism,inter religious debate,orphic literature,didactic poetry,magic stones
Fire in the land of ice: Climatic drivers and feedbacks (FireIce)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2371691.0
EU funding (EUR): 2371691.0
Participants: 1
Project status: SIGNED

2019 was the largest fire year since at least 1997 within the Arctic Circle, largely driven by Siberian fires. The arctic-boreal region stores about two atmospheres worth of soil carbon with 90 % currently locked in permafrost soils, or perennially frozen ground. Fire releases parts of this carbon stock, which may induce a vigorous climate warming feedback. FireIce will investigate feedbacks between climate warming and arctic-boreal fires by studying direct and longer-term carbon emissions from fires. FireIce will acquire highly needed observations of carbon emissions from Siberian forest and tundra fires. On top of the direct fire emissions, fires accelerate permafrost degradation, which leads to greenhouse gas emissions for several decades. Their sum may be substantially larger than the direct emissions, yet is largely unknown. In addition, FireIce will investigate the relative contribution of CH4 from smoldering fires to fire emissions. CH4 emissions represent a small, yet not well known, fraction of carbon emissions from fires, but CH4 is a more potent greenhouse gas than CO2. FireIce will investigate feedbacks between climate warming and arctic-boreal fires by studying controls on fire size and ignition. Fire growth can be limited because of fuel or fire weather limitations. The fire weather control is sensitive to warming, which may lead to larger future fires. Lightning ignition is the main source of burned area in arctic-boreal regions, and more lightning is expected in the future. By combining contemporary controls on fire size and ignition, and future predictions of climate and lightning, FireIce will assess the vulnerability of arctic-boreal permafrost and soil carbon to increases in fire. FireIce’s results will be relevant to evidence-based policy. FireIce’s innovations are conceptual, i.e. unstudied aspects of an emerging warming feedback loop, methodological, e.g. inclusion of novel spaceborne data, and geographical, i.e. a focus on Siberia.

Keywords: fire,arctic,boreal,carbon,climate,siberia,tundra,forest,permafrost
Differential regulation of gonadotropins (GTHREG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

As wild fish stocks are dwindling, aquaculture is increasingly relied upon to supply the growing world demand for fish. However aquaculture operations are largely impeded by our limited understanding of the mechanisms that control reproduction in farmed fish. The gonadotropins LH, FSH and their main stimulator GnRH are key regulators of the reproductive axis in vertebrates. We propose to utilize the unique anatomical traits and rich toolbox of the zebrafish model to dissect the mechanisms driving the differential regulation of LH and FSH. We will adopt a transgenic approach combined with state-of-the-art live imaging techniques to investigate the intricate interplay between GnRH and gonadotropes in the teleost pituitary. Taking advantage of the unique anatomy of the zebrafish, in which LH and FSH are discreet cell types, and the unique expertise of Mollard’s lab in cellular in vivo imaging of the hypothalamus-pituitary tract, we will investigate the functional role of both the circulation and direct contacts (GnRH terminals which directly abut onto gonadotropes) in delivering GnRH signals to target cells and reveal how these signals are interpreted by the gonadotropes to differentially activate LH or FSH cells. The results of the project are expected to provide new insights into the evolution and function of gonadotropin regulation in vertebrates and yield new approaches to control and manipulate the reproductive axis of commercially important species.

Keywords: gnrh,zebrafish