Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pioneering Unprecedented Life-Saving Equipment: Intelligent Aortic Balloon Catheter for Cardiac Arrest (PULSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 20.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

With a worldwide incidence expected to increase from 9 million cases in 2023 to 11 million cases by 2030, cardiac arrest is a public health crisis with survival rates around 10% and a high degree of brain damage and associated physical impairments amongst the few survivors. Despite the advent of defibrillators, these cannot be used in 76% of patients due to a non-shockable rhythm, leading to an extremely low survival-to-discharge (3.3%). Neurescue Aps (NEUR) addresses the cardiac arrest burden by bringing to market a game-changing solution – the Neurescue device – the world's first intelligent fluoroscopy-free aortic balloon catheter. By combining unique proprietary features including 1) an intelligent system for automated inflation and deflation managed by the controller component, coupled with 2) precise positioning feedback, from the patented sensor system embedded in the catheter, which together provide an unprecedented safe computer-controlled aortic occlusion for use inside and outside hospital settings. The Neurescue device increases blood flow to the heart and brain which makes the patient more likely to respond to ongoing resuscitation efforts. This also increases the likelihood of bridging patients to definitive therapies, extending the critical time window, from the current 15-30 min to ~60 min. This is especially valuable in patients with a non-shockable rhythm for whom the standard of care (SoC) results in critically poor outcomes. The use of the Neurescue device in cardiac arrest, both in and out of hospital, is expected to increase the survival rate of cardiac patients to up to 40%. The Neurescue device is projected to be ready for commercial roll-out by 2027 reaching €931.37M in revenues by 2033. The PULSE project aims to surpass the main market barriers associated with the market introduction of the Neurescue device, namely gathering data for CE-marking and clinical demonstration for market awareness and to ensure end-user medical adoption.

Keywords: cardiac arrest,advanced life support,computer controlled aortic occlusion,vital organs preservation
Transforming Financial Inclusion by Connecting Informal Economies to Formal Finance (Wakandi)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1610000.0
EU funding (EUR): 1610000.0
Participants: 1
Project status: SIGNED

A major barrier to growth and prosperity in lower income countries is access to finance. For example, a key factor in the trade disparity between Africa and Europe stems from the inability of rural African communities to access credit and financial instruments such as insurance. Individuals in these communities rely on Informal financial groups (IFGs) for savings and loans, but these institutions are not connected to the formal banking infrastructure, restricting services, and rely on inefficient and inaccurate paper-based accounting. Rather than seeking to replace trusted and well-established IFGs, Wakandi AS will instead bridge the gap between informal and formal financial sectors. Our solution is designed to enhance IFG efficiency, reduce errors, and allow end users to build credit scores and access various financial products, benefiting service providers and communities. A critical component of our approach is making the informal economy more visible to governments by digitising IFGs, thereby ensuring better recordkeeping, preventing fraud and providing transparency. This digitisation helps integrate the informal sector into the formal economy, providing governments with a clearer view of informal financial activities and facilitating better oversight, policymaking and management of the economy. Our strategy also involves forming strategic partnerships and integrating with financial services providers to extend their reach. Our approach is underpinned by a world-class team with diverse expertise in technology, management, and finance. We are further supported by strong partnerships with banks, IFGs and national governments. We have achieved market traction with a minimum viable product and now see EIC support to realise our objectives and secure the potential societal and economic benefits of a successful scale-up and large scale deployment.

Keywords: financial inclusion,social innovation,saas,fintech
ComfyCell Novel Bionic Bioreactor for Industrial Stem and Immune Cell Manufacturing (ComfyCell)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

We are entering a transformative era in medicine with the growing use of stem and immune cell therapies for cancer, neurodegenerative, and autoimmune disorders. As the industry moves towards using donor cells for multiple patients (allogeneic therapies), the demand for large-scale manufacturing of sensitive cells is increasing. By 2030, an estimated 1.12^16 cells will be needed, a four-fold increase from 2024. A major challenge in advancing allogeneic stem and immune cell therapies is scaling up the manufacturing of sensitive cells. These cells cannot withstand high shear forces or fluctuations in oxygen and pH levels, making large-scale production difficult. Current technologies, such as conventional stirred tank reactors, vertical wheel bioreactors, and wave bags, are inadequate, as they are limited to a maximum of 10L due to issues with bubble aeration, inconsistent mixing, and poor process control. These limitations result in low cell yields, inconsistent batch quality, and high operational costs, hindering the ability to meet growing demand. To address these challenges, we introduce ComfyCell, a revolutionary Bionic Bioreactor designed for the scalable manufacturing of sensitive cells. Powered by the patented Membrane Stirrer for bubble-free aeration, ComfyCell mimics the natural human body environment, ensuring optimal cell growth without damage. It enables fully scalable manufacturing from 50L to 200L (potential up to 1,000L), reducing shear forces by 95% and increasing gas transfer efficiency by 4x. ComfyCell also significantly lowers operational costs by over 70%, making large-scale cell therapy production practical and cost-effective. Within the EIC project, we aim to scale ComfyCell's bioreactor to 50L and beyond, optimizing the Membrane Stirrer for even lower-shear mixing, upgrading vessel components for higher volumes, and enhancing the in-situ perfusion system. We will pilot the 50L vessel with leading CDMOs, aiming for GMP certification.

Keywords: bionic bioreactor,bioprocessing,cell culture,cell therapy manufacturing,stem cells,immune cells,allogenic therapies,membrane stirrer,bubble free aeration,scalable manufacturing,shear forces,
Next-Generation System-on-Chip Solutions for Self-Powered Smart Edge Devices (SPEED)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ONiO is a fabless semiconductor company focused on developing advanced batteryless microcontrollers powered by ambient energy. Our aim is to translate our groundbreaking technical breakthroughs into wireless microcontrollers that our customers can use in novel batteryless solutions across a wide range of IoT (Internet of Things) segments: industrial, agriculture, buildings, retail, logistics, healthcare, consumer, etc. We developed ONiO.zero, the world’s lowest power microcontroller platform, explicitly designed to utilize ambient energy. ONiO.zero seamlessly merges energy harvesting, versatile wireless communications, robust security measures, and adaptability in a compact design. It is ideally tailored ​​to meet the demands of smart devices and IoT solutions - and make them fully batteryless. With the support from a previous EIC Accelerator project, granted in 2020, we have driven the first version of ONiO.zero to market readiness. This first commercial version is ready for production in volumes and for delivery to a growing pool of customers. While working with our lead customers and a growing pipeline of qualified leads, we identify a clear pull from the market for several added-value features - and thus a clear need to start the development cycle for the next generation ONiO.zero technology. This is the focus of the new project proposed for EIC support: to develop the second generation ONiO.zero technology, ONiO.zero_v2, based on customer feedback and market pull. This will enable ONiO to stay ahead of the game in energy harvesting and ultra low power electronics. Our ambitions are clearly aligned with the goals of the EIC Accelerator Challenge for 2024 “Enabling the smart edge”. Our goal for ONiO.zero_v2 is to develop a new class of system-on-chip semiconductor components that enable devices with a higher level of autonomy and smart edge capabilities - pushing the envelope on edge processing, sensing, communication and power management.

Keywords: wireless microcontrollers batteryless electronics energy harvesting ambient energy internet of things iot ambient iot ultra low power electronics sustainable electronics risc v
NEB Junction: The New European Bauhaus Hub For Results & Impact (NEB Junction)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Coordination and support actions
Countries involved: Norway,Austria,Netherlands,France,Germany,Belgium
Call: Setting up a New European Bauhaus hub for results and impact (HORIZON-MISS-2024-NEB-01, 2024)
Start date: 2025-05-01
End date: 2027-10-31
Duration (months): 30.0
Total project cost (EUR): 1799937.5
EU funding (EUR): 1799937.5
Participants: 8
Project status: SIGNED

NEB Junction collects, packages and validates stakeholder knowledge into Knowledge Gems, and makes them publicly available in an AI-supported, attractive and accessible IT Portal. We cooperate with a broad set of NEB stakeholders - and stakeholders that might not yet be interested or are traditionally excluded - using multi-stakeholder sessions, learning journeys and stakeholder assemblies. Our Monitoring System bridges cultural and creative perspectives with environmental, economic, social, health and governance aspects, making sustainable solutions more relatable and attractive to policy makers, public authorities, construction ecosystems and local communities. We connect stakeholders with the NEB Facility through NEB Coffees, mapping of R&I gaps, foresight activities and more, to distill NEB at your Fingertips - Pathways to NEB Implementation, and a Roadmap for the NEB Facility. We work with creative and cultural sectors and industries to generate a sense of belonging to NEB, combining AI-supported analysis with human reflections on NEB values, needs and expectations in a co-design approach. All of this work is supported by a Vision co-created with the stakeholders, enabling its long life-time also after the end of the project. The NEB Junction is created and managed by 8 experienced NEB partners: AIT, Ars Electronica, Climate KIC, DemSoc, DOWEL, ERRIN, ICLEI, and NTNU as Project Coordinator.

Keywords: new european bauhaus,neb values,neb hub,neb stakeholders,neb monitoring,artificial intelligence,knowledge hub
Knowledge Based Framework for Extended Textile Circulation​ (tExtended)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Finland,Sweden,Belgium,Portugal,Spain,Ireland,Latvia,Slovakia,France,Switzerland
Call: Circular flows for solid waste in urban environment (Processes4Planet Partnership) (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 14860675.25
EU funding (EUR): 12345596.0
Participants: 20
Project status: SIGNED

The tExtended project will achieve its overall objective of reduction of textile waste by 80% by within industrial-urbal symbiosis developing and demonstrating effective textile recovery, waste valorisation and recycling processes combined with digital tools, sensing systems and data-driven solutions to support sustainable circularity of textiles. We will develop a knowledge-based Blueprint, i.e. a master plan for a sustainable textile ecosystem. The basis of the Blueprint is a Conceptual Framework which determines the optimized utilization of textile flows, aiming for retention of value of materials in a safe and sustainable way. Based on the Blueprint, we will implement a real scale demonstrator, verifying its replicability and potential to reduce textile waste. tExtended brings together a multidisciplinary group of experts with complementary skills needed for twin transition in sustainable textile sector. Different types of organizations, research, industry, and non-profit organizations such as NGOs and municipal waste management are included. The consortium consists of actors with different roles in the textile recycling ecosystem: waste management, recycling, textile materials and textile products manufacturing. Participation of forerunner companies and actors involved in textile recycling enables us also to spread best practises for textile recovery and recycling around Europe and across the sector.

Keywords: industrial urban symbiosis,real scale demonstrator,textile recycling,waste valorisation,textile waste recovery,digital tools,sensing systems,data driven solution,social innovation spin off
COMBATTING DIET RELATED NON-COMMUNICABLE DISEASE THROUGH ENHANCED SURVEILLANCE (CoDiet)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Czechia,Spain,Belgium,Italy,Estonia,Ireland,Greece,Israel,United Kingdom,Germany
Call: Integrated surveillance system to prevent and reduce diet-related non communicable diseases (NCDs) (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7330589.25
EU funding (EUR): 7330589.25
Participants: 19
Project status: SIGNED

Our current understanding of the relationship between diet and the development of non-communicable disease (NCD) is limited by a number of factors. These include a lack of understanding of dietary mechanisms that drive NCD, inaccurate tools to collect dietary information, a nascent understanding of the role of personalised nutrition, and the lack of data in vulnerable groups where NCDs are often over-represented. The overarching aim of CoDiet is to develop a series of tools (through eight work packages) which will address the current gaps in our knowledge and lead to the development of a tool that will assess dietary-induced NCD risk. We will achieve this through the six objectives which will answer the challenges of the work programme 1: Development of AI-driven literature searching tools - bring clear understanding of large global literature in the field of physiological and metabolic links between diet and NCD 2: Enhance the understanding of NCD risk factors - we will bring a series of beyond the state of the technics to gain mechanistic insight 3: Understanding of the importance individual variation in response to diet to risk of NCD - this will give insight into the targeting of dietary NCD advice 4: Develop an enhanced method of dietary assessment using machine learning technologies - solving a fundamental problem in nutrition of lack of an accurate dietary tool 5: Develop an enhance diet-NCD monitoring tool - enabling change in NCD in response to diet to be monitored at the population level 6: Develop a dynamic interface between diet and NCD risk factor monitoring and policy - Ensuring CoDiet is applicable at a population level The investigation of these objectives and the answers they provide will open a pathway to enhancing the uptake of NCD protective diet at a population level

Keywords: diet,risk factors,machine learning,personnel nutrition
ERA CHAIR HOLDER TO ESTABLISH BIOMOLECULAR AND STRUCTURAL MASS SPECTROMETRY FOR THE ANALYSIS OF COMPLEX BIOLOGICAL PATHWAYS (MASSTRUCT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Greece
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2498562.0
EU funding (EUR): 2498562.0
Participants: 1
Project status: SIGNED

MASSTRUCT aims at establishing a world class Biomolecular Mass Spectrometry Research Unit and Facility for Excellence in the Biomedical Sciences Research Centre “Alexander Fleming”, unique in Greece and Southeast Europe. MASSTRUCT will attract and maintain a top-class researcher to build an excellent team to advance research in biomolecular mass spectrometry, structural biology and related dicsiplines at the interface between chemistry and biology. Biomolecular analysis by MS has emerged as a key tool for interrogating the conformational landscapes and interaction networks of proteins and their complexes, thus invaluably improving our understanding of fundamental biological processes, and assisting the development of new drug discovery strategies. While over the past decade, biomolecular MS has made big strides for characterising complex biological systems often intractable by other methods, it remains underrepresented in Southeast Europe and fully absent in Greece. Consequently, there is an urgent need to establish a top-class BioMS Facility. Here, we will address this issue and by establishing an emerging technology in a widening country, we will raise and sustain the research profile of a top-ranked host institute in biomedical sciences, foster wider collaborations in Greece and the wider region and leverage competitive funding and industrial partnerships. This will complement recent and current EU investments in Greece, including other powerful structural approaches such as cryo-Electron Microscopy, NMR spectroscopy, structural and synthetic biology, thus adding significant value to local science, regional economy and the wider society. Ultimately, MASSTRUCT will contribute to reverting the "brain drain" in Greece, as well as providing a platform to promote mobility and research innovation with downstream opportunities to local and regional economies.

Keywords: biomolecular mass spectrometry,structural biology,protein dynamics,drug discovery,cancer
The Drought Impact on the Climate Benefit of Carbon Sequestration (DISEQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-10-31
Duration (months): 25.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Increases in atmospheric CO2 have resulted in significant changes in global climate and ecosystem processes. It is well known that the terrestrial biosphere fixes large quantities of carbon from the atmosphere. Still, less certain is whether soil and terrestrial vegetation can mediate the increase in CO2 and for how long. Carbon storage largely depends on water constraints, and climate models predict drier future conditions, particularly in the Mediterranean. Although droughts are associated with reductions in photosynthetic rates, their effect on the role of forests in climate change mitigation is still unclear. The Drought Impact on the Climate Benefit of Carbon Sequestration project aims to advance understanding of the impact of soil moisture on forests-avoided warming and for how long it occurs by achieving three objectives: i) simulate the effect of drought on the global terrestrial biosphere C cycle under global warming scenarios, ii) develop a mechanistic model based on experimental observations to represent the carbon cycle dynamics under drought conditions in a Mediterranean forest, and iii) compare the warming produced by CO2 emissions and that avoided by Mediterranean forests under drought scenarios. These objectives will permit answering whether the climate benefit of C sequestration is sensitive to drought conditions on a global and local (Mediterranean) scale and whether Mediterranean forests mantain their offset CO2 emissions under these conditions. The above will be carried out by linking photosynthesis, storage and respiration processes through the combination of Transit Time, Carbon Sequestration, and the Climate Benefit of Sequestration concepts with measurements from a unique long-term drought experiment, the compartmental system approach and global carbon cycle models. This project will result in relevant scientific contributions and a valuable and comprehensible tool to enhance policy-oriented discussion on nature-based climate mitigation.

Keywords: carbon sequestration,transit time,drought,long term experiment,mediterranean forest ecosystem,global warming scenarios,climate change mitigation,forest management