Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Monitor Multiple Sclerosis evolution using body fluids derive cell-free epigenomics (MonitorMS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Multiple sclerosis (MS) affects 2.8 patients worldwide, 700000 in Europe alone, and is characterized by subsequent phases of different severity which eventually evolve into a chronic phase and untreatable paralysis. Current main diagnostic approaches are limited to symptom evaluation and imaging, underlying a lack of informative and reliable biomarkers. MonitorMS aims to test the use of cell-free Chromatin (cfChromatin) present in the plasma and cerebrospinal fluid (CSF) as a new biomarker to monitor the progression of MS pathology and response to treatment. The proposal includes the development of a new technology based on nanoCut&Tag(nanoCT) to improve and simplify the current methodology used to profile cfChromatin. Recently, it has been demonstrated that cell-free DNA in plasma is still wrapped around histones which still preserve the presence of post-translational modifications, termed cfChromatin. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has been recently used to profile cfChromatin from plasma of patients affected by liver, and heart damage or cancer showing a pathology and stage-specific signature. To decode the information inside cfChromatin a reference dataset is needed. The first aim of MonitorMS is to develop a protocol to profile cfChromatin from plasma/cell-free CSF with nanoCT and compare it to the actual reference (ChIP-seq). In the second phase, the technology will be employed on a larger cohort of samples from a KI biobank, including patients under immunosuppressant treatment. Simultaneously a single-cell multimodal dataset, from matched MS patients' immune cells and post-mortem tissues, will be generated to deconvolve the informative content of cfChromatin. The final phase of the project will include further integration of the generated cfChromatin data with several MS single-cell transcriptome and spatial data. Finally, machine learning will be used to test cfChromatin as a stage/treatment-specific biomarker in MS.

Keywords: single cell neuro immunology multiple sclerosis cell free dna precision medicine diagnostic
Transforming the Story of the Arabic Book, 700–1800: Knowledge, Information Technology, and the Arabic Book (KITAB-Transform)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom,United States
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2547189.0
EU funding (EUR): 2547189.0
Participants: 2
Project status: SIGNED

The premodern Arabic textual tradition between 700 and 1800 is one of the most prolific in human history, with the number of surviving works surpassing the extant production of any other pre-print culture except perhaps imperial China or Sanskritic India. These texts can now be studied in completely new ways using pioneering digital technology that can identify textual units displaying what one scholar has termed ‘extended textual similarity’. This means not only word-for-word matching, which can be detected by existing techniques and has been computationally studied, but also textual overlap obscured by transformations such as paraphrase and translation. By identifying, documenting, and interpreting this kind of transformational reuse across thousands of Arabic books, KITAB-Transform’s team of eight historians, linguists and computer scientists will uncover hitherto obscured connections between texts and shed light on the writerly attitudes and practices that created the Arabic written tradition and continue to shape Islamicate societies’ reservoirs of memory today. The project relies on a vast corpus of digitised texts that continues to grow thanks to an OCR pipeline developed by team members. KITAB-Transform will produce interdisciplinary monographs and edited volumes, journal articles, blog posts, language models, and data sets, as well as a web application through which less technically inclined scholars can access and work with our data, supported by a robust outreach programme. Our work will make an important contribution to Arabic book history and help redress a significant imbalance in the development of large language models, which favour English and modern social media but are comparatively impoverished for historical languages.

Keywords: arabic,islamicate,historiography,cultural memory,digital humanities,text reuse
Physical Internet and the Key steps to Innovation-driven supply chain transformation towards Green, Affordable, scalable and collaborative Zero-EmIssions Freight Transport solutions (IKIGAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Italy,Greece,Belgium,Germany,Spain,France,Luxembourg,Netherlands,Switzerland
Call: Scaling up logistics innovations supporting freight transport decarbonisation in an affordable way (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-07-01
End date: 2028-12-31
Duration (months): 42.0
Total project cost (EUR): 11854005.0
EU funding (EUR): 9999351.38
Participants: 32
Project status: SIGNED

IKIGAI, inspired by the Japanese concept combining “iki” (meaning “alive”) and “gai” (meaning “worth”), aims to accelerate the realisation of the PI by 2040 and achieve decarbonised freight transport and logistics by 2050. The project focuses on the establishment of affordable, collaborative, and coordinated Systems of Logistics Networks across Europe. It promotes the adoption of open standardised processes to enhance efficiency and reduce emissions, aligning with the UN 2030 sustainable development agenda. IKIGAI will scale up five complementary and forward-looking Logistics Innovations (LIs) (advancing them from TRL5 to 8, looking also into other scalability aspects e.g. regulation, market and social), building collaboration on shared resources and capacity, respect, openness, transparency and trust: [LI1] Online and offline trustee matchmaking and volume pooling for electrification and increased intermodality, [LI2] eFTI compliance Collaborative Service Platform for SMEs, [LI3] Smart and synchromodal hubs for hyperconnected urban logistics, [LI4] Intelligent, standard end-to-end chain of custody for carbon emission calculation, [LI5] Open volume pooled governance for reusable standard modular boxes. Recognising that companies can better evolve collaboratively, aligning logistics and decarbonisation within a unified transition path, IKIGAI will drive the Twin Transition to net-zero logistics by mobilising an open and collaborative ecosystem of global supply chain players committed to systemic change. Beyond adopting the LIs and testing them in real-world pilots, IKIGAI will re-engineer supply chain logistics services (Sx) such as volume pooling/asset sharing, warehousing, freight forwarding/intermodality, cross-docking and last-mile delivery.

Keywords: physical internet,shared resources,decarbonised freight transport,collaboration,norm,standard
Innovative, minimally invasive device to support the natural movement of the heart in heart failure patients (Heart Function Support)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-09-01
End date: 2027-03-31
Duration (months): 55.0
Total project cost (EUR): 25695814.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Syntach CS is a groundbreaking, life-saving device for long-term cardiac support that restores the natural function of the heart’s mitral plane movement in patients suffering from left ventricular heart failure. The technology is based on recent findings of the physiological movement of the intact heart, which pumps with a scooping, longitudinal movement of the mitral valve. In heart failure, this movement is impaired and the heart is unable to pump enough blood to meet the metabolic needs of the body. Syntach CS works in synchronization with the heart, supports the cardiac movements and reestablishes a natural, healthy movement. It is fully implantable in a minimally invasive procedure. Heart movement support is enabled thanks to a mitral anchor ring connected to a drive unit implanted in the lower apex region of the heart from which a pulsatile movement is transferred to the mitral plane. The system is recharged and monitored wirelessly with no elements protruding through the skin.

Keywords: new treatment method,heart failure,active implantable medical device,medical devices,cardiac support,cardiac systems
Politics of Otherness in Contemporary Concert Dance: (In)visibilities on Stage and the White Gaze (POLITENESS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

This research addresses the experience of Otherness in Swiss contemporary concert dance, exploring the mechanisms of othering/exclusion. Drawing on the under-representation of Black dancers in Swiss theatres, contrasted with their prominence in Sub-Saharan African dances and Hip-Hop (and on international theatre stages), the research focuses on the few dancers who have managed to carve out a place within this predominantly White dance institution. It aims at understanding how their bodies are perceived under the White gaze: exoticized, eroticized, sexualized? The near absence of African female dancers, the racial challenges faced by Black female dancers born in Switzerland, and the growing demand for recognition of queer identities in Swiss art, are crucial aspects of this study. A special focus lies on the double exclusion faced by Black sexual minority identities. Rooted in social anthropology and dance studies, this investigation combines choreographers’ and dancers’ perspectives with performance narratives and dance institutions’ discourses. It addresses a significant gap in European scholarly research on contemporary concert dance regarding the experiences of ‘Othered’ dancing bodies, articulating race, gender and dance. The project aims at uncovering the imaginaries embedded in the White gaze projected onto dancing Black bodies, examining the disruptive strategies used by dancers/choreographers considered as ‘Others’ to subvert dominant norms, and assessing the presence of structural racism in dance institutions. As Black dancers increasingly assert their visibility, and as diversity policies recently emerged in Switzerland, this research aims to contribute to social transformation echoing the Black Lives Matter movement. Thereby, it challenges Switzerland’s self-perception of its history as being devoid of colonial influences and confronts its responsibilities regarding race issues.

Keywords: anthropology,blackness,contemporary dance,otherness,racism,white gaze
Developing and Validating Soma Aware: Harnessing Eye Tracking Data for Real Time Cognitive Monitoring outside the Laboratory (Soma Aware SDK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2100000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: SIGNED

In today’s high-demand industries, real-time cognitive monitoring is crucial for operational success and risk minimisation. However, existing methods face significant limitations. Traditional pen-and-paper tests lack ecological validity, induce test anxiety, and focus on a narrow range of abilities. Advanced technologies like EEG and fMRI, while insightful, are complex, obtrusive, and impractical for real-world applications outside laboratory settings. Clinician observations are often subjective and non-standardised. Current eye-tracking technologies oversimplify gaze behaviour, ignore critical environmental factors like brightness, and fail to offer personalised, accurate insights. Addressing these shortcomings, Soma Reality introduces its revolutionary Soma Aware SDK, a comprehensive solution for real-time cognitive activity monitoring and analysis. Our unique technology leverages advanced eye tracking to measure three critical biomarkers-cognitive load, conscious perception, and situational awareness—in real-time, using only eye-tracking data. SOMAREALITY is the only company offering a comprehensive real-time cognitive assessment by integrating these three digital biomarkers. We are pioneers in real-time monitoring of these individual biomarkers and uniquely provide a full cognitive monitoring solution by combining them. By modelling environmental brightness, our SDK ensures accurate measurement of pupil dilation, crucial for precise cognitive load assessment. The Soma Aware SDK features advanced algorithms for holistic cognitive assessments, using pupillometry and real-time calibration. It minimises false positives, ensures non-invasive monitoring, and integrates seamlessly into existing systems. By enhancing human-robot interaction and decision-making, it supports Industry 5.0 applications. This aligns with the EIC Accelerator Challenge 2024, enabling virtual worlds and AI-driven augmented interactions for high-impact applications.

Keywords: human computer interaction and interface,bioinformatics cogntive load cogntive insights virtual reality augmented reality neuropschology
Unravelling FRESHwater and ocean Currents changes in the Arctic using REmote sensing (FRESH-CARE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499482.0
EU funding (EUR): 1499482.0
Participants: 1
Project status: SIGNED

The Arctic is warming rapidly, causing significant hydrographic changes including sea ice retreat, freshwater accumulation, and altered ocean currents. These changes intensify water stratification potentially destabilizing Earth's thermohaline circulation. Despite its key role in global climate system, the ultimate fate of Arctic freshwater remains unconstrained. Current estimates lack the resolution that remote sensing and Artificial Intelligence (AI) can provide. It is crucial to improve freshwater flux uncertainties, to better constrain future projections and understand global climate impacts. FRESH-CARE aims to transform our understanding of Arctic freshwater dynamics. It will develop innovative methodologies that leverage (radiometric, thermal, and altimetric) satellite data, AI-integrate remote sensing and in-situ information, and run model simulations to forecast freshwater transports under various Shared Socioeconomic Pathways. FRESH-CARE will focus on three specific objectives: (1) develop a novel AI-based methodology to characterize four-dimensional ocean currents; (2) quantify freshwater transports through the main Arctic gateways; and (3) perform simulations for future Arctic freshwater scenarios using a coupled ice–ocean model. Overall, I envision that FRESH-CARE will offer a multidisciplinary view of ocean currents and freshwater fluxes in the Arctic Ocean over three decades, from hindcast in the 2010s to forecasts into the 2040s. FRESH-CARE will provide pan-Arctic estimates of ocean currents and freshwater distribution with high spatiotemporal resolution, benefiting polar oceanographers, earth modelers, and climate scientists, as well as to the society at large. FRESH-CARE findings will enhance the understanding and assimilation of ocean freshwater in future global climate models.

Keywords: arctic oceanography freshwater ocean current remote sensing
Network for European Exascale Systems (NET4EXA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Norway,Greece,Italy,France
Call: Innovation Action in Low Latency and High Bandwidth Interconnects (HORIZON-EUROHPC-JU-2023-INTER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 71108947.23
EU funding (EUR): 26916520.51
Participants: 8
Project status: SIGNED

The NET4EXA project aims to create an advanced interconnect for HPC and AI systems, including Large Language Models, that will scale to hundreds of thousands of computing nodes. The interconnect forms the backbone of such systems, and their overall performance is intimately tied to the scalability of the network and its tight coupling with the high-end compute elements. Building on the successful BXI* European HPC Interconnect, whose earlier versions (BXIv1 and BXIv2) have been deployed in European supercomputers ranking among the TOP15, and based on the research for its evolution carried out in the RED-SEA and other previous European RIA projects, NET4EXA will pursue the development of the next generation of European Interconnects (BXIv3). This includes both the switch and network interface, encompassing both hardware and its associated software. The project will showcase a fully functional Pilot at TRL 8, poised for adoption and integration into exascale and post-exascale European supercomputers. NET4EXA will also prepare the subsequent version, BXIv4, planned for implementation after this Innovation Action. The project will contribute by offering analysis and preliminary design for upcoming interconnect features, thus paving the way for continued progress in the field. Leveraging two decades of BULL experience in building HPC solutions, with now more than 40 Top500 entries in 2024, the project outcomes will fit the technological requirements for state-of-the-art HPC solutions to be implemented in European and international supercomputers and datacentres from 2025 onward. *BXI: BullSequana eXascale Interconnect

Keywords: inter node interconnect,switch,nic network interconnect card,fpga
Technology to detoxify oilseeds / fruit seeds that contain cyanogenic glycosides to upcycle and making them edible and usable in the food industry for the first time (Cyanide Extraction Technology)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-05-31
Duration (months): 27.0
Total project cost (EUR): 3539975.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: CLOSED

Millions of tons of oil seeds / fruit seeds, especially their protein-rich presscakes currently go to waste as they contain a too high amount of cyanogenic glycosides. As these naturally present substances are toxic at a certain level of consumption, these seed(-presscakes) currently cannot enter the food industry and are as a result being disposed. Kern Tec has developed a process to remove these cyanogenic substances and therefore detoxify the seeds which upcycles these raw materials from waste to superfood. The results are food safe seed(-presscakes) as a processable protein-powder that can be used as ingredients in the food industry in various applications where plant based proteins are demanded.

Keywords: upcycling,cyanides,plant based proteins
Integrated Sensing, Localization, and Communications in 6G THz Systems (6G-ISLAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

In parallel to the evolution of 5G communication systems, 6G concepts are being developed in the academic community. In 6G, several key technical enablers are envisioned: i) mmWave and THz frequencies electromagnetic with extremely large bandwidths, and extremely large antenna arrays; ii) reconfigurable intelligent surfaces that control the propagation environment; and iii) machine learning to solve problems for which mathematical models are not sufficient. As location-aware communication (i.e., to optimize network efficiency and communication capacity by exploiting location, map, and trajectory information) is already a part of 5G, we expect that the 6G key enablers will also lead to high-accuracy sensing and localization and, in turn, improve communication quality. The goal of this project is to develop integrated sensing, localization, and communication systems for 6G, and the project comprises the following 3 work packages (WPs). In WP1, joint parameter estimation methods for the 6G channel are studied, and low-complexity methods will be developed based on the inherent high resolution of the 6G channel. By exploiting the estimated channel parameters of 6G signals, novel methods for estimating user state as well as sensing the time-varying propagation environment will be developed in WP2. We will design methods to use sensing and localization information from WP2 for initial beam search, beamspace processing, beam alignment, and power allocation in WP3. In doing so, we address several of the fundamental challenges in 6G communications and high-accuracy sensing and localization.

Keywords: 6g,channel estimation,joint sensing and communications,multi target tracking,thz frequencies