Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Devising a personalized risk stratification and holistic management for prevention of cognitive impairment in patients with different cardiovascular phenotypes (DORIAN GRAY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Italy,Czechia,Germany,Greece,Romania,France,United States,Luxembourg,Cyprus,United Kingdom,Switzerland,Netherlands,Belgium
Call: Personalised prevention of non-communicable diseases - addressing areas of unmet needs using multiple data sources (HORIZON-HLTH-2024-STAYHLTH-01-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 11419355.3
EU funding (EUR): 10921114.68
Participants: 25
Project status: SIGNED

DORIAN GRAY project investigates the link between cardiovascular disease (CVD) and Mild Cognitive Impairment (MCI) in the ageing population. Its goal is to uncover underlying mechanisms to promote healthy, independent, and active living while reducing disease burden. Aligned with Horizon Europe’s Strategic Plan on NCDs prevention, the project focuses on two core objectives: designing a multidomain intervention to delay CVD-related MCI progression and developing digital solutions to enhance its adherence. By leveraging large datasets that include omics, brain imaging, lifestyle behaviors, and socio-economic data, the project aims to develop a trustworthy AI tool for predicting MCI. The AI tool will be upgraded into a state-of-the-art framework for modelling and simulation (digital twin), integrating real-world data collected in clinical studies from smartwatches and mobile devices. Including these digital biomarkers enable the early detection of disease and enhance precision in healthcare. The DIGITAL TWIN will inform and update a personalized multidomain intervention using a novel avatar-based coaching exergame, which will serve dual purposes: as a cognitive enhancement tool with structured physical-cognitive tasks and as a lifestyle intervention promoting positive behaviours experienced in the virtual environment. Feasibility will be tested in a pilot randomized controlled trials involving patients with MCI and heart failure, and in an implementation study with patients having MCI and cardiovascular risk factors. To achieve his aim DORIAN GRAY brings together a diverse team of experts, including clinicians, psychologists, sports scientists, computers engineers, AI specialists, stakeholders, entrepreneurs, and academics in ethics, law, and theoretical philosophy. Patients and citizens actively engage in shaping and guiding project decisions. DORIAN GRAY is projected to prevent up to 2 million dementia cases over 27 years, leading to a cost reduction of 485 billion.

Keywords: cognitive impairment dementia artificial intelligence digital twin omics exergame digital coaching
Electrified CO2 Capture using HiGee Vortex Reactors (e-CAPTURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

The fossil fuel-driven chemical industry is notorious for its massive CO2 emissions and energy consumption, demanding an urgent shift toward cleaner, more efficient technologies, with CO2 capture as a critical component. Existing gas-liquid reactive absorption/solvent regeneration technologies, relying on bulky packed columns or motor-driven rotating packed beds, fall short due to transport limitations and scale-up challenges. e-CAPTURE seeks to revolutionize the field with a scalable and electrified reactor that uses flow kinetic energy to generate powerful centrifugal forces without mechanical rotation, overcoming transport limitations in interphase mass transfer, mixing, and heat transfer, pushing reaction rates to theoretical limits while slashing energy demands. My objective is to build and demonstrate the e-CAPTURE reactor, aiming for at least a tenfold increase in transport-reaction efficiency and a 50% reduction in energy demand over existing systems. To achieve this, I will: 1) unlock a deep understanding of transport-reaction fundamentals under extreme centrifugal forces and shear rates, observed with cutting-edge temporal (0.1 µs) and spatial (0.1 µm/pixel) resolutions, via innovative techniques like ultra-high speed imaging and infrared planar laser-induced fluorescence. 2) develop a computational fluid dynamics-driven multiscale modeling platform to unravel CO2 interphase mass transfer, turbulence-chemistry interaction, and heat dynamics. 3) address design-performance relation of the e-CAPTURE reactor by multi-objective optimization and conduct reactive demonstration for impurities removal, CO2 absorption, and solvent regeneration with integrated Joule heating. Through a synergy of advanced visualization, state-of-the-art simulation, and real-world testing, I will deliver a transformative reactor technology—not only making CO2 capture scalable and economically viable but also serving as a general gas-liquid reactor for sustainable chemical engineering.

Keywords: gas liquid process intensification equipment mixing,heat and mass transfer separation technologies carbon capture engineering microfluidics flow chemistry
The Social Life of Early Medieval Normative Texts (SOLEMNE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1955000.0
EU funding (EUR): 1955000.0
Participants: 1
Project status: SIGNED

SOLEMNE studies how ideas about social norms, expressed in works of canon law, spread throughout medieval Western Europe, using an innovative digital tool to analyse the transmission of combinations of authoritative statements in canonical collections. Canonical collections are in essence compendia of rearranged ‘authoritative statements’ (canones) drawn from a large body of authoritative texts. As a genre that ‘intersects with every aspect of medieval life and society’ [Rennie, 2008], works of canon law, in varying degrees of sophistication, survive in a vast number of medieval manuscripts and address not only religious concerns, but also social, moral, political, and economic issues. SOLEMNE is built on the premise that it is through the (re)arrangement of authoritative statements that medieval scholars articulated the changing medieval attitudes about social norms and societal ideals. SOLEMNE aims to be the first large-scale analysis of this dynamic process of appropriation and reorganisation of authoritative statements by developing a unique database and digital tool designed to identify and map the transmission of combinations of textual elements. Building on this innovative database, SOLEMNE will study three central phenomena: the medieval negotiation of canonical authority throughout the Middle Ages (approx. 500-1200 CE) to address individual objectives and specific contexts; the compositional strategies to communicate social norms and ideals; and the transmission of ideas through canon law. In addition to the well-known ‘grand’ collections, SOLEMNE includes mostly overlooked canonical florilegia in its analysis, expanding the breadth of canonical studies. Through its open access online presence, SOLEMNE addresses the issue of the inaccessibility of canonical sources, while its interdisciplinary methodology offers a wide applicability in the study of legal, social, political, and intellectual history.

Keywords: medieval canon law transmission of ideas
Algorithmic Governance - A Public Perspective (AGAPP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499736.0
EU funding (EUR): 1499736.0
Participants: 2
Project status: SIGNED

In our digitalising world, algorithmic systems are widely used in public governance. However, evidence suggests that algorithmic governance is perceived as less legitimate compared to governance that involves humans. Despite well-known deficiencies and biases in human decision-making, perceived legitimacy of algorithmic governance increases when humans are present in some capacity (so-called humans-in-the-loop). I argue that in order to explain the legitimizing effect of humans-in-the-loop we need a theory of how legitimacy judgments are created and changed in the minds of individuals when they encounter algorithmic systems of rule. To this end, AGAPP infuses the study of political legitimacy with a theory of ecological rationality stemming from cognitive science. I propose a novel Legitimation Heuristic Model to explore the cognitive dynamics of legitimacy judgments as context-bound evaluations. The empirical investigation focuses on a new European Travel Information and Authorisation System (ETIAS). ETIAS is a paradigmatic case of algorithmic governance as it relies on big data and algorithms to perform risk profiling and implement migration policy. This project collects empirical data on how individuals assess the legitimacy of ETIAS by means of rigorous mixed-method research design. It integrates methods from Human-Computer-Interaction research (think-aloud protocols of participants’ interaction with a mock-up ETIAS interface) and includes visual elicitation into focus groups and survey experiments to ensure effective treatment. AGAPP breaks new ground as it extends the use of heuristic assessment models to legitimacy research. While AGAPP focuses on applications of Legitimation Heuristics Model to algorithmic governance, if the model turns out to be an accurate portrayal of legitimacy judgment process, it has wider implications for other governance contexts and for the study of cognition of legitimacy more broadly.

Keywords: algorithmic governance,legitimacy,ecological rationality,heuristics,evaluative judgments,automation,algorithmic decision making,digitalisation in public sector
Towards a gene therapy for age-related macular degeneration (AMD) (Opti-AAV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

While the blood neural barriers represent significant hurdles for the development of gene therapies for neurological and ophthalmological conditions it is now becoming clear that many of these conditions actually present with disrupted barrier integrity as the driving force of the pathology. Included in these diseases is age related macular degeneration (AMD), in which we have shown that the blood retina barrier (BRB) is sub-clinically disrupted and is a key driving force for disease progression (ERC funded Retina Rhythm project). Specifically related to this Proof of Concept grant, a novel form of therapy for the end stage of AMD, namely geographic atrophy (GA), is now desperately needed. A targeted approach to locally delivering adeno associated virus (AAV) to endothelial cells of the BRB would offer the opportunity to restore barrier function and prevent disease. However, the current tools available to achieve this localized approach to gene therapy are not optimum. Here we will use an exosome encapsulated and endothelial cell specific AAV to achieve robust transduction of retinal endothelial cells. This modified and optimized AAV (Opti-AAV) will represent a novel tool in translating recently identified biological mechanisms into real and meaningful therapies for patients.
Synthesis of bio-based non-isocyanate polyurethanes and their modification towards industrial application (SPRUT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

This project is devoted to synthesis of non-isocyanate polyurethanes (NIPU) from bio-based sources and their post-modification towards industrial application. The use of bio-based monomers for NIPU synthesis allows to overcome the dependence on fossil resources and to reduce the CO2 emissions. However there are several possible drawbacks for industry such as high prices for bio-based monomers and demand for arable land to ensure large scale production. NIPU were introduced in 1990s as the alternative to conventional polyurethanes because they allow to avoid usage of toxic isocyanates. However, they were not industrialised due to their insufficient molecular weights limited by reaction ability of monomers and increased hydrophilicity that facilitates hydrolysis during processing. The SPRUT project will simultaneously deal with several NIPU related issues. At first, the effective catalyst based on Al heteroscorpionate complexes for converting bio-based bisepoxides to 5-membered cyclic bicarbonates via CO2 addition will be developed. The obtained bicarbonate bio-compounds will be used as feedstock for production of NIPU applying various approaches to increase their MW above 20000 Da: synthesis in bulk, copolymerization of two different bicarbonates and the use of ionic liquids. In the 2nd stage of the project, the unique method for post-synthetic modification of NIPU that was never used for these polymers will be introduced to increase their mechanical properties and processability. The basic “click” reaction of bio-based aldehydes (heptaldehyde and benzaldehyde) with adjacent hydroxyl groups in the NIPU backbone enables the reduction of intermolecular hydrogen bonding leading to better processability. The resulting aldehyde modified NIPUs containing non-polar side chains are supposed to be much more hydrophobic and possess increased physico-mechanical properties compared to previously developed NIPU and even some conventional PUs.

Keywords: polyurethanes nipu bio based polymer modification vitrimers
Singularities in General Relativity (SINGinGR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Greece
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1312180.0
EU funding (EUR): 1312180.0
Participants: 2
Project status: SIGNED

One of the outstanding open mathematical problems in General Relativity is to understand how singularities form in solutions to the Einstein equations. Singularities are typically found in the interior of black holes or at the Big Bang. The main objective of this proposal is to start a research group at the University of Crete that will develop novel mathematical techniques, combining ingredients from analysis, partial differential equations, and differential geometry, which will enable us to prove the formation of singularities in various new settings and test long-standing conjectures in the field. Dynamics of Big Bang singularities. In vacuum, the generic cosmological singularity is conjecturally spacelike, local, and oscillatory. The only rigorous evidence in favor of the latter scenario is restricted to homogeneous solutions. We intend to construct Big Bang singularities containing spikes or oscillations, without symmetries and analyticity, that test the conjectural picture. Here, previous work of the PI with J. Luk constructing Kasner-like singularities will be useful, since they are the building blocks of more complicated scenarios. We also intend to dynamically study the submanifold of Big Bang singularities having no oscillations, by advancing techniques recently developed in work of the PI and collaborators to prove stable Big Bang formation in the sub-critical regime. The black hole interior problem. The stable phenomenon that has been observed so far in black hole regions is Cauchy horizon formation. Our goal is to show that in certain regimes, a similar situation to that of Big Bangs occurs, where part of the inner black hole boundary is spacelike and singular. We consider the Einstein-massless-scalar field system, as well as the classical Oppenheimer-Snyder dust model of gravitational collapse, for a class of initial data outside of spherical symmetry, where singularity formation has not yet been understood.

Keywords: general relativity,einstein s equations,big bang singularities,black hole interior,hyperbolic partial differential equations
Reliability, Resilience and Defense technology for the griD (R2D2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Slovenia,Estonia,Greece,North Macedonia,Serbia,Portugal,Cyprus,France,United Kingdom
Call: Reliability and resilience of the grid: Measures for vulnerabilities, failures, risks and privacy (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 9732750.0
EU funding (EUR): 7335337.5
Participants: 21
Project status: SIGNED

R2D2 strategic goal is to improve the resilience and reliability of current EPES (Electrical Power and Energy Systems) against a growing number of threats and vulnerabilities that may affect such critical infrastructure, exposing weaknesses with harmful and damaging effects on different stakeholders and final customers. This will be done through the deployment of four tools dedicated to the prevention, protection and restoration of EPES in two different independent but complementary scenarios in the energy value-chain – from regional coordination between TSOs, to privacy of LV customers. The project will build on top of strong energy coordination actions in South-East Europe (SEE), following EU legislation and in alignment with the recent activities promoted by ENTSO-Eabout cyber-security in transmission systems. Through the demonstration and integration of the innovative solutions proposed by R2D2, it will be possible to achieve a more secure, reliable and resilient energy system in Europe, making a positive and tangible impact throughout the European EPES value chain. In this context, R2D2 will deliver a palette of complementary solutions synthesised into four Products: “Multi-risk assessment framework for power system” (P1 – C3PO), “Resilience suite for TSO & DSO” (P2 - IRIS), “Prevention Systems For Energy Infrastructures Security” (P3 - PRECOG) and “Enhanced Assets Maintenance And Management Toolkit” (P4 - EMMA).

Keywords: reliability,resilience,electrical power and energy systems,distribution,transmission,cyber security,
Improving energy access and climate resilience in Africa’s fringe communities (AfricaEnergyParks)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Denmark,South Africa,Ghana,Germany,Norway,Portugal
Call: Accelerating the green transition and energy access in Africa (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 6552152.5
EU funding (EUR): 4994556.75
Participants: 12
Project status: SIGNED

We will establish a Renewable Energy Park (REEP) in a rural community fringing the Mole National Park in Ghana to demonstrate energy access and climate resilience using the water-energy-food-ecosystem (WEFE) nexus approach. We will replicate a plug-and-play microgrid developed under the ongoing Horizon project “RePower”, using solar photovoltaics (PV), battery energy storage system (BESS) and biomass combined heat and power (BCHP). To increase energy demand of the community, we will develop technologies and activities for the productive use of energy (PUE) using a circular economy approach, whereby waste generated from agriculture and food processing serves as feedstock for the BCHP plant and cookstoves. An estimated 900 million Africans have no access to clean cooking and over one million deaths occur annually from use of firewood and kerosene involving mainly women and children. We will test and promote the use of improved cookstoves (ICS) that can be easily integrated into the current traditional cooking system. This will help to arrest intrusion into the protected wildlife park for fuelwood which has led to widespread deforestation and loss of biodiversity. We will use life cycle approaches to measure the social, ecoconomic and environmental impacts of the project and cooperate with other LEAP-RE and CCSE projects to facilitate the adoption of the results across Africa. We will identify and catalogue sources of funding including public and private investors and international private and donor funding. Attention will also be given to building local value chains for materials supplies and a skilled workforce for the operation and maintenance of the microgrid and PUE components. The REEP will be fully operational by the end of the project period and is expected to become financially self-sustainable within 5 years. Our business model will be based on a public-private partnership and include other sources of financing such as sale of carbon credits.

Keywords: energy park,off grid microgrids,energy access,climate resilience,cookstoves,pue