Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mission Trajectory in ATC and Network Management Operations (MITRANO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Belgium,Spain,Romania,France,United Kingdom,Italy,Denmark,Poland,Germany
Call: Industrial Research & Validation for Civil-military Interoperability & Coordination (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 15260401.25
EU funding (EUR): 7286667.03
Participants: 14
Project status: SIGNED

The MITRANO project validates the management of mission trajectories and civil-military CDM at network level and in ATC operations, including advanced design principles for the military access to airspace, the DMA of type 3, and provides a technological solution for aircraft surveillance data protection, hence proving enhancement of civil-military cooperation and interoperability in ATM. Furthermore, the validated solutions will contribute to the digital transformation of European ATM, by using as core of information exchange, data sets created and disseminated automatically by technical systems, hence supporting operators and decision-makers to increase the efficiency of their activities. Nevertheless, the project supports the implementation of a Green Single European Sky by reducing the airspace segregations in the ATM network, hence enabling all categories of airspace users to fly more direct and efficient routes with a positive impact to the reduction of emissions. The validation activities are organized within three solutions: two operational and one technological, CNS related that ensure the development and validation of three overarching R&I topics: • Mission Trajectory in the ATM network execution phase through associated network management and ATC processes • Mission Trajectory with DMA of type 3 • Security aspects for ADSB (Automatic Dependent Surveillance-Broadcast) phase overlay The key operational expected results reside in uptake from civil and military ATM stakeholders of the MT validated concept and the associated network level civil-military CDM and on the DMA type 3 concept. Furthermore, ADS-B authentication layer and resilience to integrity attacks, and the definition of a management system capable of distributing authentication keys to aircraft is a key expectation. The expected outcomes will bring performance benefits in the areas of airspace capacity, environment, operational eficiency, civil-military coordination, and security.

Keywords: civil military cooperation and interoperability mission trajectory dynamic mobile areas adsb cybersecurity aircraft surveillance phase overlay collaborative decision making
Putting the top down on AMPK protein complex (Top-AMPK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2026-01-31
Duration (months): 42.0
Total project cost (EUR): 336829.68
EU funding (EUR): 336829.68
Participants: 4
Project status: SIGNED

The 5' adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of cell energy metabolism. AMPK (dys)regulation has been connected to metabolomic disease, conditions of the heart and viral infections. AMPK is fine-tuned through its structural features, which are dependent on mRNA isoform splicing, protein complexation, post-translational modification (PTM), and allosteric activation . AMPK’s diverse regulatory role is deeply connected to its post-translational modifications (43 known phosphorylation and 36 known other PTM sites). The result of this structural diversity is an extremely large combinatorial space of (1) unique covalently modified α-β-γ isoforms, the proteoforms, and (2) their unique non-covalent assemblies, the complex species. However, the structural diversity of AMPK is not well understood. The goal of this project is to to study the modifications and endogenous diversity of AMPK proteoforms and complex species from a "bird's eye view", depicting and mapping in parallel existing complete length AMPK forms, using denatured and native Top-down Mass Spectrometry (TDMS). -Outgoing phase, Ying Ge Lab, University of Wisconsin-Madison (UWM) (M1-24): Recombinant AMPK complex to study coded proteoforms (O1-2) and establish a strategy for purification of endogenous AMPK (O3). -Incoming phase (M25-36), Charlotte Uetrecht Lab, University of Lübeck (UzL): Transfer learned technologies and map endogenous AMPK proteoforms in different tissues (O4). Design endogenous-ike AMPK proteoforms (O2). -Non-academic phase (M37-42) Bruker Daltonics GmbH (BRUKER): Close gaps in data acquisition and get more out of AMPK with next-gen MS instruments (O2). The aspired methodology and results will be important for the identification of AMPK biomarkers and, ultimately, for the advancement of precision medicine, where treatment is tailored for the individual molecular setup of a patient subgroup such as in metabolomic or heart disease.

Keywords: top down mass spectrometry,ampk,proteoform
THE ROMAN TURN AMONG JEWS, GREEK PAGANS, AND CHRISTIANS (ROMANA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ROMANA aims to unveil the ubiquitous presence of Rome in Jewish, Greek-Pagan and Christian texts and to expose the strategies of cultural interaction between imperialist forces and a range of minority groups. It will explore how intellectual discourses that have defined the West, namely those of Greek elites, Christian groups, as well as Hellenistic and rabbinic Judaism, were constructed through a series of contested, hidden, and disavowed interactions with the dominant force of empire. The project will redraw the traditional map of the Roman Empire to challenge its sharp dichotomy between Rome and the provinces and demonstrate the deep entanglements of each group of “provincial” elites despite their claim to cultural purity. The starting point is first-century Hellenistic Judaism, as its main representatives—Philo and Josephus—became active in Rome as prolific authors writing in Greek, who combined philosophical, literary and legal interests with a keen appeal to Roman audiences. Their modes of acculturation will serve as a compass to unlock similar cultural entanglements in the Second Sophistic, early Christianity and rabbinic literature. The project objectives entail a focused study of three trajectories, philosophical, literary and legal, to be exposed as doubly entangled, namely with each other and with Roman discourses. The method will be a close, comparative and culturally aware reading of whole corpora of texts in Greek, Hebrew/Aramaic and Latin, based on the available manuscripts, moving through Greek-Christian writing into Rabbinic Judaism and the texts that contest the space between them. We will reach insights of a new order in fields which have thus far been overwhelmingly studied in double isolation or on the limited basis of digital searches of keywords. The results will be published in 6 monographs, special issues in leading journals, a consultation at an international conference and wide dissemination in Israel, up to changes in school curricula.

Keywords: philosophy,literature and law,culture and religion in the roman empire jews,pagans and christians
Sustainable Sodium-Ion Battery Advancements through Catalytic Single-Atom Electrochemical Kinetics Boosters (SSiON-ACSENT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-09
End date: 2027-06-08
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

The SSiON-ACSENT project seeks to advance sodium-ion battery (SIB) technology by addressing key challenges such as limited lifespan, low energy density, and slow charging rates. By developing high-performance anode and cathode architectures incorporating single-atom catalysts (SACs) on MXene, metal-organic frameworks (MOFs), and bio-derived carbon, the project aims to significantly enhance battery performance. These SACs, through precise d-orbital tuning and heteroatom coordination, improve metal ion adsorption and conversion kinetics, thereby boosting overall battery performance. The anticipated outcomes align with the European Commission's ambitious climate strategy, targeting climate neutrality by 2050 while reducing dependence on critical raw materials. SIBs, leveraging sodium's abundance and environmental benefits, represent a sustainable alternative to lithium-ion batteries (LIBs). Pre-commercial SIBs have demonstrated energy densities around 160 Wh/kg, but SSiON-ACSENT aims to raise this range to 200-350 Wh/kg (an increase of 25-118%), with an improved cycle life of 5000-8000 cycles (a 25-100% improvement) and enhanced safety. By integrating SACs into 3D porous structures, the project focuses on improving Na-ion intercalation, optimizing electrode-electrolyte interfaces, and accelerating ion transport, overcoming the current limitations of SIB technology. This research directly supports the Horizon Europe mission for affordable, clean energy and aligns with the European Green Deal and MSCA Green Charter by promoting sustainability and responsible consumption. The innovations within the project contribute to advancing energy storage solutions and transitioning toward sustainable energy systems.

Keywords: nanomaterials sodium ion batteries sustainable energy storage single atom catalysts battery testing in situ diagnostics theoretical insights
Quantum Dynamic Control of Atomic, Molecular and Optical Processes (Q-DYNAMO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Latvia,Italy,United States,Japan,Germany,New Zealand
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 404800.0
EU funding (EUR): 404800.0
Participants: 12
Project status: SIGNED

The Project represents a coordinated experimental/theoretical effort in developing and testing quantum protocols. Within a worldwide academy and industry effort to develop quantum computers, based on quantum qubits and quantum Hamiltonian, the quantum protocols, i.e. well designed Hamiltonian acting on the qubits, represent important steps. Even if the qubits offer enormous computation power, the quantum target may be reached more efficiently, more rapidly and with more stability using properly designed quantum protocols. Within this Project These new protocols will be tested on the natural qubits easily assessed in worldwide research laboratories: simple atoms and molecules. The experimental and theoretical tools should be classified with the broad area of quantum optics, where the photons, typically from laser sources, create the control quantum protocols, and the atoms/molecules constitute the qubits where quantum information is stored and maipulated. The Project will apply this quantum control approach to open theoretical and experimental problems such as: implementation of a molecular all-optical spin switch via control of spin-orbit interaction, realization of molecular orientation, superadiabatic protocols for the coherent control of cold atoms and molecule, control of ultracold chemical reactions, and spin-polarized quantum emitters. The objectives of the project will be achieved via an intensive transfer of knowledge among the EU and TC participants in the consortium during the carefully planned secondments. The consortium members are well established specialists in various aspects of physics of light-matter interactions, including theoretical, experimental and numerical techniques, and therefore all participants will benefit from the SE scheme for staff exchange to collaborate and achieve new results in this area. The gender balance in the consortium is well kept, with three of the team leaders being female.

Keywords: quantum control,quantum information,rydberg atoms,spin orbit coupling,autler townes effect,all optical spin switch,ultracold chemistry,rydberg atom ion molecule,nano optics,optical nanofiber
The Imperial Encounter in Early Islamic Egypt: Dissecting the Aphrodito Archive (IMPERIAL ENCOUNTER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2192235.0
EU funding (EUR): 2192235.0
Participants: 2
Project status: SIGNED

Named ‘Aphrodito archive’ because it originates in that otherwise unremarkable Middle-Egyptian town, the most important papyrological archive of the early Caliphate contains the papers of an early-eighth-century district administrator, including correspondence with the provincial governor in the new Muslim capital Fustat, and with village heads in his district, as well as registers and accounts generally related to tax and resource extraction. Known for over a century, the Aphrodito archive remains underexploited, largely because of its inaccessibility. Its three languages (Arabic, Coptic, Greek), difficult-to-access editions, and lack of translations have acted as a break to its study, and the partial nature of the existing translated texts (mainly those coming from above) has created a skewed view of its nature, which is much more organic and dialectical than has been allowed for. IMPERIAL ENCOUNTER will make this invaluable group of documents available to scholars by providing a full translation of the archive’s documents IMPERIAL ENCOUNTER will also use this archive to produce a microhistory of the Aphrodito area and its engagement with the new empire. Containing documents from above and from below, the archive admirably illustrates the Caliphate’s conception of empire and its implementation strategy on the one hand, and local reception empire on the other. A team with the necessary linguistic skills will produce several microhistorical studies exploring some key questions for the Umayyad caliphate and the functioning of early medieval empires: the balance between coercion and negotiation, the role of archives in establishing power, the indigenous reception of empire. In this key period of ostensible power display by the Umayyads, the documents found in rural Aphrodito mention such projects as the building of the Umayyad mosque in Damascus and demonstrate how they affected tiny villages in a different province, providing a textbook case of global microhistory.

Keywords: papyrology,medieval egypt,umayyad caliphate,coptic studies,indigeneity,empire studies,late antiquity
Development of sociality and social relationships and maintenance of social structure over generations in the closest evolutionary relatives of humans, the great apes (SOCIALITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-04
End date: 2026-11-03
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

Sociality is an evolved trait, which forms the basis of primate societies. It influences individual survival, reproduction, access to information, and disease transmission. As early-life experiences have long-term consequences, knowledge of individual developmental history has contributed well to understanding the factors that underlie variation in individual health, longevity, resilience to internal and external stressors, amongst other crucial aspects of an animal’s life. Therefore, studying aspects of individual development is fundamental to understanding how individuals become well-adapted to their environment. Great apes live in complex societies with constantly changing opportunities for associations and interactions, for which they make complex cognitive decisions just like humans. As they are our closest evolutionary relatives, long-term developmental studies on them are indispensable to understand how the development of the social life of humans evolved. National and international collaborations focused on data and knowledge sharing for comparative studies on great apes will help to overcome the current gaps in our knowledge about human social evolution. The future fellow will collate two decades of fine-scale observational data collected on individually identified great apes from birth until the start of adulthood from four great ape projects. The aims are to 1. investigate, at the individual level, the development of sociality and social relationships, 2. investigate, at the population level, social inheritance of social structure over generations, and 3. develop a general theory of social structure maintenance. This action will be the first to take a large-scale, data-intensive, and comparative approach to studying the social life of immature great apes using a combination of cutting-edge computational tools and analytical methods. The results of this action will bridge fundamental gaps in our knowledge of Hominidae sociality and social structure.

Keywords: great apes,sociality,social development,immatures,social structure
Smooth muscle cell modulation by the MaR1-LGR6 duo: novel role in the resolution of human cardiovascular inflammation. (MaResIn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Atherosclerotic cardiovascular disease (ASCVD) is a progressive disease characterized by aberrant immune activation and chronic vascular inflammation as a result from a failure in the resolution phase. However, the mechanisms responsible for this dysregulation are not well understood. Little is known about the role of smooth muscle cells (SMCs) in regulating resolution of inflammation, an active process orchestrated by endogenous specialized proresolving lipid mediators (SPMs). These include the maresin family, and in particular maresin 1 (MaR1), which was recently shown to be a specific activator of LGR6. Despite the potent anti-inflammatory and proresolving actions of MaR1 in murine models and human cells, its role in ASCVD remains uncovered. Hence, this proposal aims to elucidate the role of SMC-derived resolution of inflammation in ASCVD, and the impact of MaR1-LGR6 in stimulating resolution. Specifically, I will focus on the molecular mechanisms of MaR1-LGR6 signaling, mainly on the phagocytic capacity of SMCs. I will employ mechanistic and functional assays in human SMCs, as a proxy for its potential in plaque “clearing” and plaque stabilization. I will characterize the expression of LGR6, by mass spectrometry imaging, and the biosynthesis of MaR1 in human atherosclerotic tissue (local) and identify indicators in blood samples (systemic) by LC-MS/MS-derived lipidomic profiling of human samples, in to obtain a profile of systemic lipid biomarker(s) that reflects the local abundance of SPMs or their receptors. This could be used to design personalized proresolving prevention in prone-to-CVD individuals. Lastly, I will investigate the SMC phenotypic modulation by MaR1-LGR6 in a LGR6-specific SMC-deletion ASCVD mouse model. Deciphering the SMC-mediated resolution programs in inflammation (a novel concept in ASCVD), and the involvement of MaR1-LGR6 in this process, will be a major advance in understanding chronic cardiovascular inflammation and its mechanisms.
Chirality detection: nanoparticles for optimised plasmonic enhancement of circular dichroism (NanOptCD) (NanOptCD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland,Austria,Germany,Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 5
Project status: SIGNED

NanOptCD aims to facilitate the sensitive use of plasmonic enhanced circular dichroism (CD) spectroscopy in research & development (R&D). Many molecules possess weak CD signals below the measurable limit. Interactions of molecules with plasmonic nanoparticles are very promising for generating strongly enhanced CD signals. Nevertheless, this enhancement mechanism needs further theoretical characterisation in order to facilitate mature applications in R&D. NanOptCD will offer this by analysing the fundamental dependencies of plasmonic CD enhancement with ab initio calculations. Furthermore, NanOptCD will deliver tools for the analysis of plasmonic enhanced CD spectra and customised nanoparticles for optimal plasmonic enhanced CD spectra.

Keywords: ab initio spectroscopy chirality plasmonics nanoparticles