Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tunable InP Quantum Dot-based Au Nanoresonators to Outcompete Auger Recombination Losses via Photonic Enhancement (InPforPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

InPforPE aims to mitigate energy losses in semiconductor quantum dots (QDs) resulting from Auger recombination (AR) throughInPforPE aims to mitigate energy losses in semiconductor quantum dots (QDs) resulting from Auger recombination (AR) through photonic enhancement. Despite the wide-ranging applications of QDs, such as energy-efficient displays and light-emitting diodes, their full potential is hindered by the adverse effects of AR-induced losses. Auger recombination, a significant and inevitable non-radiative decay process, occurs on a timescale of approximately 100 ps for multi-carrier states of QDs. This phenomenon obstructs the utilisation of QDs in high-intensity lighting applications and laser systems. Previous efforts to address these challenges have focussed on reducing the rate of AR. Here, we propose a disruptive new approach in which we enhance the rate of the radiative transitions, and hence the rate of absorption and emission through photonic enhancement, aiming to outcompete AR. The photonic enhancement is achieved by encapsulating QD within a metallic Au nanoshell, acting as a plasmonic nanoresonator to leverage electric field effects. The primary objective is to synthesise and characterise InP-based Au nanoresonators, covering a range of emission wavelengths from green to red. The emission wavelength is tuned by changing the core size of the InP QD, which is a direct manifestation of the quantum confinement effect exhibited by these particles. Furthermore, we aim to study the charge carrier dynamics in these systems at both ensemble and single-particle levels. The enhanced radiative lifetime and biexciton quantum yield of InP QDs in the presence of an Au metallic shell will be valuable for their use as light-emitting materials or optical gain media for lasing. The proposed system aligns well with the EU's Work Programme, advancing eco-friendly technology for efficient displays, high-output light-emitting diodes, lasers, and optical communication.

Keywords: excitons,emission properties,energy,electric field,semiconductor quantum dots,nanoresonator,single particle pl spectroscopy
STOP 2030: TOWARDS THE INTERRUPTION OF TRANSMISSION OF SOIL-TRANSMITTED HELMINTHS: PROMOTING IMPLEMENTATION OF RESEARCH RESULTS OF A FIXED-DOSE COMBINATION OF CO-FORMULATED IVERMECTIN AND ALBENDAZOLE (STOP2030)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,Kenya,Ghana,United Kingdom,Switzerland
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 3553502.25
EU funding (EUR): 3553502.25
Participants: 7
Project status: SIGNED

Soil-Transmitted Helminths (STH) remain a significant public health problem with recognized obstacles for control and elimination with the current benzimidazole regimens in Mass Drug Administration (MDA) campaigns. Renewed targets from WHO for 2030 include elimination of STH morbidity in pre-school and school age children (PSAC & SAC), increased country governance and financial support and a strongyloidiasis control program; 2030 has also been targeted by WHO for controlling NTDs to attain the Sustainable Development Goals. The current proposal aims at accelerating the implementation of an innovative health technology, a fixed-dose combination (FDC) tablet of co-formulated albendazole and ivermectin, with adequate safety and significantly superior efficacy against T. trichiura in a registrational randomized clinical trial. This trial is being conducted in Ethiopia, Kenya and Mozambique with the guidance of EMA and sponsored by EDCTP (STOP projects) with a Phase II trial completed and a Phase III currently recruiting. This project, STOP2030, seeks to complement the results of the safety and efficacy trial with a field-based safety and effectiveness clinical study, acceptability studies in Ghana and Kenya, modelling and cost-effectiveness exercises. The resulting information will be consolidated to build a multidisciplinary package for policy making and WHO guidance with the support of advocacy and communication activities to reach stakeholders and maximize the exploitation and impact of the FDC for STH control and elimination. The Consortium assembled to execute the STOP2030 proposal combines expertise in complementary fields from program assessment and implementation through Ministries of Health in sub-Saharan African countries, advocacy, state of the art technology, leadership in clinical research and a pharma that has shown commitment for generating access to drugs against NTDs and has recently obtained WHO prequalification for generic ivermectin.

Keywords: soil transmitted helminthiases,ivermectin,albendazole
Using deep learning to understand computations in neural circuits with Connectome-constrained Mechanistic Models (DeepCoMechTome)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1997321.0
EU funding (EUR): 1997321.0
Participants: 1
Project status: SIGNED

Advances in experimental techniques yield detailed wiring diagrams of neural circuits in model-systems such as the Drosophila melanogaster. How can we leverage these complex connectomes, together with targeted recordings and perturbations of neural activity, to understand how neuronal populations perform computations underlying behavior? Achieving a mechanistic understanding will require models that are consistent with connectomes and biophysical mechanisms, while also being capable of performing behaviorally relevant computations. Current models fail to address this need: Mechanistic models satisfy anatomical and biophysical constraints by design, but we lack methods for optimizing them to perform tasks. Conversely, deep learning models can be optimized to perform challenging tasks, but fall short on mechanistic interpretability. To address this challenge, we will provide a machine learning framework that unifies mechanistic modeling and deep learning, and will make it possible to algorithmically identify models that link biophysical mechanisms, neural data, and behavior. We will use our approach to study two key neural computations in D. melanogaster. We will build large-scale mechanistic models of the optic lobe and motor control circuits which are constrained by connectomes and physiological measurements, and optimize them to solve specific computational tasks: Extracting behaviorally relevant information from the visual input, and coordinating leg movements to achieve robust locomotion. Our methodology for building, interpreting and updating these `deep mechanistic models' will be applicable to a wide range of neural circuits and behaviors. It will serve as a powerful hypothesis generator for predicting neural tuning and optimizing experimental perturbations, and will yield unprecedented insights into how connectivity shapes efficient neural computations in biological and artificial networks.

Keywords: computational neuroscience,probabilistic machine learning,model identification,fruit fly,drosophila melanogaster,visual system,motor control,deep learning,simulation based inference,bayesian inference,mechanistic models,connectomics,big data,animal behavior
The emergence of “actin stars” for epithelium coordination and tissue patterning (ActinStar)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Faithful epithelial morphogenesis is crucial during development and tissue homeostasis. The dynamic intestinal epithelium is an appropriate model to study this field of research. Constant regeneration of epithelium is one of the main characteristics of intestinal homeostasis mediated by finely controlled balance between intestinal stem cell proliferation and differentiation. Therefore, it is instrumental to study mechanisms controlling intestinal organization to understand tissue homeostasis and function. Actin cytoskeleton plays an important role in regulating epithelial morphogenesis. Recently, by using 2D and 3D intestinal organoids, the host lab has discovered a new unique multicellular star-shaped actin assembly, termed “actin stars” (AcSs) located in the basal domain of differentiated epithelium. This network is characterized by 6-branched star-shaped actin clusters covering the entire basal surface, with AcS node at the centroid of the cell and each branch of the star orthoradially connects the plasma membrane, and directly mirrors a corresponding branch from a neighbouring cell. They confirmed such actin structures in vivo in mouse small intestine. The AcSs may represent a large-scale inter-connecting meshwork in the differentiated epithelial domain. Considering the novelty of these results, we would like to investigate the interplay between large-scale AcS networks and tissue morphogenesis. Here we aim to dissect the organization of AcS network, determine the processes leading to their formation, and understand the importance of AcSs for individual cells as well as epithelial assemblies. For that we will carry out a multi-disciplinary approach, combining the use of high-resolution imaging, optogenetics, genomics coupled to physical modelling. We anticipate that our results will have a significant impact in understanding the role of AcSs in epithelial differentiation, tissue homeostasis in physiological and pathological conditions.

Keywords: actin cytoskeleton,actomyosin network,contractility,epithelium,intestinal organoid,cell shape,morphogenesis,mechanobiology,cellular biophysics
Scar-Facebook: Organized Crime and Populist Digital Media Politics in Contemporary Naples, Southern Italy (Scar-Facebook)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The interactive forms of mass communication that characterize digital platforms of social mediation such as Facebook and Instagram intersect the institutional life of current democracies on multiple levels while serving as powerful ?echo chambers? for a plethora of rather controversial populist political agencies. As shown by the Ph.D. dissertation I have defended at the University of Toronto in 2019, this is especially true within subaltern social spaces such as those punctuating the urban peripheries of Naples, Southern Italy. There, far-right movements and criminal organizations regularly employ the online social media to elicit consent amid the local poor and establish dynamics of political patronage with them. How do legal and criminal processes of digital networking cooperate in the entrenchment of populist politics within the most socially vulnerable areas of current democracies? How do these processes impact the socio-cultural lives of the Neapolitan poor in terms of political mobilization? What public policies and social interventions could challenge the conditions of structural violence and indirect governmentality engendered by these populist processes of digital mediation in Naples and beyond? My project will respond to these questions by providing ethnographic insights on the informal dynamics of digital mediation co-involving current Neapolitan gangsters, populist institutional operators, and their lower-class publics. I will conduct this project through innovative qualitative methods of socio-cultural research, which will integrate the ethnographic techniques I have learnt and practiced during my previous anthropological studies with the online techniques of ?net-nographic? analysis informing the fields of digital media studies and digital humanities. I plan to do so through my engagement with the University of Amsterdam. As such, this project will also allow me to be reintegrated within EU academia after ten years of scholarly work in North America.

Keywords: organized crime,populism,digital media,informal politics,subaltern politics,naples,italy
DELTA-HUB: RIVER DELTA SCIENCE, EDUCATION, AND MODELING HUB (DELTA-HUB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Romania
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2490375.0
EU funding (EUR): 2490375.0
Participants: 1
Project status: SIGNED

DELTA-Hub aims to establish a competitive ERA Chairs research centre at the University of Bucharest (UniBuc) under the supervision of an outstanding research manager in the field of river delta science. This transformation will be achieved through i) integrating premier research with innovative educational programs (MSc and PhD); ii) attracting top scientists to bolster the academic and research rankings; iii) promoting structural changes within the UniBuc aimed to increase researcher mobility and collaborations. It aims to cultivate excellence and diversity, boost visibility, and increase competitiveness for EU funding, significantly enhancing UniBuc's research excellence and administrative capacity. This initiative capitalizes on existing knowledge, resources, expertise and recently created infrastructure at UniBuc transforming DELTA-Hub into an excellence hub for inter-disciplinary research of deltaic environments in the Mediterranean-Black Sea area. Over 60 months, the project will involve 18 people (ERA Chair holder, 4 senior and 8 junior scientists, 4 administrative personnel and 1 technician; out of which 9 new positions to be recruited). This effort aligns with the ERA Chairs program and with key European and global priorities such as Black Sea SRIA, HE Mission 3, UN SDGs, EU Green Deal and EU environmental infrastructures DANUBIUS-RI, LIFEWATCH and REXDAN. Eight WPs focus on management, enhancing research and educational excellence, capacity building, collaboration, and ensuring sustainable impact on environmental management and policy. Engaging with stakeholders, policymakers, and the broader public, promoting sustainable sediment management practices and developing strategies to mitigate environmental challenges facing deltaic regions, DELTA-Hub will create conditions for enhanced adaptability, sustainability, and continuity of ecosystem services in these vulnerable areas through informed decision-making and management.

Keywords: danube river delta,delta sustainability and resilience,sediment dynamics,msc and phd programs,structural changes,capacity building,environmental management and policy,stakeholder engagement
Knowledge Graphs, AI Services and Next Generation Instrumentation for Research and Development in Social Sciences and Humanities (GRAPHIA)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Belgium,Italy,France,Cyprus,Germany,Poland,Sweden,Netherlands,United Kingdom,Switzerland
Call: R&D for the next generation of scientific instrumentation, tools, methods, solutions for RI upgrade (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 8183498.75
EU funding (EUR): 8183498.75
Participants: 21
Project status: SIGNED

Social Sciences and Humanities (SSH) provide essential knowledge to society, informing our shared cultural, economical and ethical decisions. However, SSH knowledge remains largely disconnected and poorly available, impeding its full potential in research and societal applications. The GRAPHIA project aims to build the first comprehensive SSH Knowledge Graph (KG) that integrates currently disconnected data into a single entry point, leveraging existing infrastructure and data resources. GRAPHIA aspires to significantly improve SSH data visualisation and analysis capacities, pioneer advanced AI solutions tailored for SSH and develop re-usable, cutting-edge digital tools. GRAPHIA addresses the unique opportunities posed by the qualitative, diverse and context-rich data typical of SSH research where existing solutions fall short. GRAPHIA's innovative approach, centered around the KG, provides an expansive representation of SSH knowledge, while leveraging AI for its enrichment, access and deeper analysis, including an LLM4SSH. GRAPHIA aims to empower researchers to uncover patterns and insights from unstructured data, illuminating social phenomena and cultural trends with unprecedented clarity. A key component of GRAPHIA is the SSH Citation Index, an innovative framework for citation data extraction and enrichment across all SSH disciplines that dramatically speeds up access and understanding of previous literature on any topic. GRAPHIA transcends traditional research approaches by integrating industry partners into a cohesive partnership, which is pivotal to amplify the project's impact, drive forward innovations that are not only academically significant but also commercially viable, provide access to new markets and technologies and foster an environment of co-innovation. GRAPHIA is committed to open science and increasing EU Research Infrastructures capabilities, enhancing global competitiveness, while facilitating broad and long-lasting impact of project results.

Keywords: knowledge graphs,artificial intelligence,instrumentation,social sciences,humanities,interdisciplinary,industry,innovation labs,open science,data interoperability,natural language processing
Restoring DNASEs antiviral potential (REDAVIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-13
End date: 2027-01-12
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Every individual carries at least a herpesvirus causing mild to serious diseases without definitive cure. Although in theory, herpesvirus genomes can be degraded by host DNA nucleases (DNASEs), the ER preliminary data has evidenced DNASE2B protein levels to decrease upon herpes simplex virus-1 (HSV-1) infection. In order to restore DNASEs anti-viral potential, REDAVIP aims to 1) uncover the susceptibility of DNASEs to HSV-1, 2) gain mechanistic insights of HSV-1 proteins and DNASEs interaction, and 3) screen drugs restoring host DNASEs so the vDNA can be cleared from the organism. To do so, REDAVIP will assess DNASEs’ endogenous levels upon infection by immunoblot and enrich them with immunoprecipitation to identify interacting viral protein(s) by mass spectrometry collaborating internationally. Afterwards, their minimal interacting surfaces will be determined and disrupted with in silico drug library screens collaborating internationally. Then, a tripartite fluorescence complementation assay will confirm the disruption of this pathogenic interaction in cellula. Candidate compounds restoring the DNASEs ability of degrading vDNA will be validated by plaque assays for IP protection, since they may represent a first step towards an overdue cure against herpesviral infections and life quality improvement, especially for an ageing population. Given the ambitious and novel objectives, the ER applies her multidisciplinary expertise to propose mitigation strategies that will ensure experimental feasibility and multiple outputs. This work will allow the ER to transfer her knowledge acquired through European laboratories to the acceptor institution, and progress from basic to translational research to learn and ensure a revenue of invested funds. The findings will be broadly disseminated to improve the ER soft skills. Uncovering how host DNASEs are impaired during herpesvirus infection using HSV-1 as a model is an asset to find novel antivirals against further viruses.

Keywords: herpesvirus,dnases,proteomics,drug screens,fluorescence complementation