Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From Open to Closed Loop Optimal Control of PDEs (OCLOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Austria,Austria
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 1678325.01
EU funding (EUR): 1540726.81
Participants: 2
Project status: CLOSED

The proposal addresses some of the most pressing topics in optimal control of partial differential equations (PDEs): Non-smooth, non-convex optimal control and computational techniques for feedback control. These two topics will be applied to the large scale optimal control problems for the bidomain equations, which are the established model to describe the electrical activity of the heart. Due to their rich dynamical systems behavior these systems are particularly challenging. The use of non-smooth functionals is of great practical relevance in many diverse situations. They promote sparsity, and provide a perfect formulation for switching and multi-bang controls, and for the optimal actuator location problem. For inverse problems the case $L^{p}$ with $p\in (0,1)$ is of special statistical importance, and $L^0$ can be the basis of a new formulation for topology optimization problems. But lack of Lipschitz continuity and of convexity are significant obstacles which can only be overcome by the development of new analytical and numerical concepts. The new algorithmic concepts will also be applicable to important non-smooth problems in continuum mechanics, as for instance the quasi-static evolution of fractures. Closed loop control is of paramount importance due to its {\bf robustness} against system perturbations. Nevertheless, numerical realization of optimal feedback strategies for nonlinear PDEs has barely been touched since the curse of dimensionality makes direct numerical treatment of the Hamilton-Jacobi-Bellman equation unfeasible. We shall therefore develop and analyze suboptimal strategies based on model reduction and interpolation techniques, and on model-predictive control. The availability of boundary and near-to-the boundary measurements together with dynamic observer techniques will allow to test the proposed methods to obtain suboptimal feedback controls for the bidomain equations.
ALK Activation as a target of TRAanslational Science (ALKATRAS): Break free from cancer (ALKATRAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Austria,Germany,Germany,Germany,Germany,Italy,Italy,Germany,Italy,Sweden,France,France,Czechia,Czechia,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 3849199.56
EU funding (EUR): 3849199.56
Participants: 23
Project status: CLOSED

This ETN is embedded into an established international research programme; The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA; www.erialcl.net) is an existing and functional network of 13 partners, which will cosset and nurture a cohort of early stage researchers to become confident, competent, independent and well-connected European scientists with excellent career perspectives. ERIA was instigated to coordinate research into ALK-related malignancies to facilitate the development of less-toxic and more efficacious therapies. ALK is increasingly recognised as a prevalent oncogene in a number of human malignancies and therefore poses a prominent clinical problem, which requires coordinated research into its oncogenic mechanisms. ERIA now conducts a collaborative multidisciplinary research programme at the interface of biomedical and bio-mechanistic approaches, which will be an excellent environment to train the next generation of European scientists. The 15 recruited fellows will be incorporated into international academic study groups (all partners of the ERIA network) to perform high calibre research and also will be exposed to environments from other sectors to broaden their experience. Secondments will include technical training within individual laboratories and SMEs (TissueGnostics, Galkem, Cambridge Life Sciences, Sofigen and Varionostics) as well as large Pharma (Roche). Training through research will be complemented with a balanced programme of transferable skills and access to local courses. The training of each fellow will be guided by a personal career development plan and supervised by a PhD committee panel. The primary goal of the network is to train the recruited fellows by participation in an internationally competitive research programme and integrating them into an international network. Thereby providing competence in state-of-the-art research and development at the forefront of translational science.

Keywords: lymphoma,anaplastic lymphoma kinase
Predicting adaptive responses of protected species to environmental changes to optimise conservation management frameworks in Europe (ADAPTATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-14
End date: 2018-11-13
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Environmental changes, including habitat loss and climate change, are negatively impacting biodiversity at global levels, with accelerating extinction rates of species. Whilst the EU Biodiversity Strategy aims to halt and then reverse these losses of species, data on the conservation status of many protected species is lacking, inhibiting their management. Effective conservation is reliant on robust data on protected species, yet there is a substantial knowledge gap between traditional monitoring methods that record abundances and conservation management frameworks that require the integration of species’ ecology with their adaptive responses to rapidly changing environments. The primary aim of this Fellowship is to thus deliver a novel conservation management framework for a model protected species, integrating ecological and genetic data, to provide a new predictive basis for European conservation management programmes. The sea lamprey Petromyson marinus is the model species, a protected species on Annex II of the EU Habitats Directive that provides multiple generations for testing the effects of environmental change on candidate genes. Research objectives quantify P. marinus European genetic diversity and structure, test for the presence of novel genetic mutations across populations, identify the genetic regions associated with adaptation to specific environmental parameters and develop an eco-evolutionary model of P. marinus population dynamics as the basis for its conservation management framework. As the project delivers highly innovative genetic and ecological research, it brings together a leading European researcher with high genetic knowledge with a European research group with exceptional expertise in conservation ecology. Together, their knowledge transfer and training activities will deliver novel conservation tools supporting European conservation strategies and launch a new research agenda in biodiversity and conservation management.

Keywords: genetic diversity,sustainability,freshwater fishes
The Politics of Wealth Inequality and Mobility in the Twenty-First Century (WEALTHPOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-10-31
Duration (months): 66.0
Total project cost (EUR): 1696109.0
EU funding (EUR): 1696109.0
Participants: 1
Project status: SIGNED

Over the past decade scholars across the social sciences have grappled with the causes and consequences of economic inequality and social mobility. Income inequality has risen to levels unseen for a century. At the same time, economies in Europe and beyond have seen an even larger concentration in wealth, along with unprecedented volatility in asset markets such as housing and equities. These changes in the distribution of wealth have been of great economic and political consequence, with the debates over housing, inheritance, and capital taxation shaping contemporary political discourse. Yet, scholars of political economy remain beholden to analyses of inequality and mobility that examine only the flows of income in the labour market and ignore inequality and mobility in the stock of wealth held by citizens. WEALTHPOL is a ground-breaking interdisciplinary project with a series of three high-risk and novel work packages that transform our knowledge about wealth inequality and wealth mobility. WEALTHPOL 1 develops the first comprehensive collection of data about the distribution and inheritance of wealth in Europe and beyond. WEALTHPOL 2 provides the first political database of how governments shape the pattern of wealth through political pledges and policymaking, spanning seven decades and thirty-seven countries. Finally, WEALTHPOL 3 uses cutting-edge laboratory and survey experiments to expand our knowledge about what citizens think about wealth. WEALTHPOL draws these three strands together by connecting policy environments and the distribution of wealth to citizens’ attitudes to wealth inequality and the kinds of policies that might shape it. In doing so, WEALTHPOL revolutionises our understanding of - and our capacity to respond to - the politics of capital in the twenty-first century in Europe and beyond.

Keywords: political economy of wealth
COMPASS: Climate-relevant Ocean Measurements and Processes on the Antarctic continental Shelf and Slope (COMPASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 3499269.98
EU funding (EUR): 3499269.98
Participants: 1
Project status: SIGNED

Processes on the Antarctic continental shelf and slope are crucially important for determining the rate of future sea level rise, setting the properties and volume of dense bottom water exported globally, and regulating the carbon cycle. Yet our ability to model and predict these processes over future decades remains rudimentary. This deficiency in understanding originates in a lack of observations in this inaccessible region. The COMPASS project seeks to rectify that by exploiting new technology - autonomous marine vehicles called gliders - to observe, quantify and elucidate processes on the continental shelf and slope of Antarctica that are important for climate. The COMPASS objective is to make a step-change in our quantitative understanding of: (i) the ocean front that marks the boundary between the Antarctic continental shelf and the open ocean, and its associated current system; (ii) the interaction between ocean, atmosphere and sea-ice on the Antarctic continental shelf; and (iii) the exchange of heat, salt and freshwater with the cavities beneath ice shelves. These goals will be met by a series of targeted ocean glider campaigns around Antarctica, spanning different flow regimes, including areas where warm water is able to access the continental shelf and influence ice shelves, areas where the continental shelf is cold and fresh, and areas where the continental shelf hosts cold, salty, dense water that eventually spills into the abyss. A unique circumpolar assessment of ocean properties and dynamics, including instabilities and mixing, will be undertaken. COMPASS will develop new technology to deploy a profiling glider into inaccessible environments such as Antarctic polynyas (regions of open water surrounded by sea-ice). As well as scientific breakthroughs that will feed into future climate assessments, improving projections of future sea level rise and global temperatures, COMPASS will deliver enhanced design for future ocean observing systems.

Keywords: antarctica,marine autonomous vehicles
Targeting Meniscus Degradation in Osteoarthritis (TARGETMENISCUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 1973764.0
EU funding (EUR): 1973764.0
Participants: 1
Project status: SIGNED

My goal is to determine the molecular degradation of meniscus tissue, a “new” disease that leads to degenerative meniscus tears and osteoarthritis (OA). My prior research has revealed that meniscus tears are a frequent entity in OA, not typically caused by knee trauma. By focusing on the meniscus, we aim to discover novel biomarkers and new targets for pharmaceutical intervention against OA, by preventing meniscus degradation and stimulating its regeneration. In our ageing population, the burden of OA is rapidly increasing, making the first disease-modifying OA treatment an urgent matter. The proposal is based on my biobank consisting of human tissue from total knee joint replacements, knee arthroscopies, and healthy donor knees, including menisci, synovial fluid, hyaline cartilage, and blood. The two linked work packages are: WP1 Proteomics: Identification of the proteome of the meniscal matrix and biomarkers of degeneration using exploratory and targeted mass spectrometry. WP2 7T imaging: Arthroscopy patients will undergo ultra-high field 7-Tesla magnetic resonance imaging (MRI) pre-operatively and at two follow-ups. Using both high-resolution and emerging compositional imaging sequences, we will determine meniscus matrix degradation and hyaline cartilage quality changes after knee surgery. Importantly, we will link proteomics with early stage knee OA development to provide proof-of-concept that the identified biomarkers and molecular treatment targets are associated with OA. My key team members include orthopaedic surgeons, an analytical chemist with expertise in mass spectrometry, a medical physicist with expertise in MRI, and a biostatistician. We further work in international collaborations. As the principal investigator, I have an internationally recognized track record in OA research, with a novel focus on the meniscus. We will accomplish our goals by our combined expertise, unique materials, state-of-the-art methods, dedication, and continued hard work.

Keywords: biomarkers,proteomics,orthopedics,rheumatology,magnetic resonance imaging,osteoarthritis,biomechanics,mass spectrometry
Biomedicine international training research programme for excellent clinician-scientists (BITRECS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Italy,Spain,Tunisia,France,United States,United Kingdom,Portugal,Canada
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-10-01
End date: 2023-06-30
Duration (months): 69.0
Total project cost (EUR): 2124000.0
EU funding (EUR): 1062000.0
Participants: 20
Project status: SIGNED

Significant advances in clinical practice cannot be made without a thorough understanding of the disease mechanisms from laboratory benches combined with good clinical observation and knowledge of disease management from the bed side. Clinician-scientists are the only professionals who can bridge these two worlds. The clinician-scientist role started decades ago within hospitals driven by the desire to understand and cure. However, a decrease in these vocations is now threatening progress and improvement of healthcare, thereby impacting on economic competiveness worldwide. IDIBAPS, the leading biomedical research institute of Hospital Clinic of Barcelona (Spain) as pioneer in fostering clinician scientists, proposes a 60-month innovative fellowship programme called BITRECS, Biomedicine international training research programme for excellent clinician-scientists, based on excellence only. Through 2 international peer-reviewed calls, it invites 10 fellows to implement a 36-month bottom-up research project through an outgoing phase (12-18 months at any worldwide institution outside Spain) and a return phase (18-24 months at IDIBAPS), helping to make a lasting impact within the European Research Area and put the European Union ahead of the game in this crucial area of human health. BITRECS is an international, intersectorial and interdisciplinary programme. This transnational mobility scheme will boost the fellows’ professional growth through: 1) continuous career support (scientific supervision, career mentoring and support for exploiting/disseminating the results); 2) participation in scientific and non-scientific training/networking activities linked to both sectors (academic and non-academic); and, 3) sharing experiences with peers from different disciplines. IDIBAPS, with its HRS4R strategy aligned to the European Charter and Code and a strong background in other human resources programmes guarantees a successful implementation.

Keywords: clinician scientist,excellence,fellowship,outgoing,return scheme,biomedicine,career development,training,results exploitation,results dissemination,idibaps hrs4r,clinician,scientist
Understanding the Stability and Plasticity of Emotional Memory (ErasingFear)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 2498328.0
EU funding (EUR): 2498328.0
Participants: 1
Project status: SIGNED

The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insights, we have developed a novel approach to pharmacologically erase the affective component from fear memories in humans. Although these findings suggest a paradigm shift in clinical practice, there are many fundamental questions to be resolved. The objective of this proposal is to gain an in-depth, comprehensive understanding of the dynamic balance between the stability and malleability of emotional memory, and consequently develop a revolutionary theory-driven treatment for emotional memory disorders. This program presents a novel mechanistic framework on memory reconsolidation challenging in several ways the dominant model of emotional memory modification. First, while during traditional interventions cognitive changes are required for a reduction in fear, in our procedure cognitive changes preclude the neutralization of fear memory. On the other hand, post-retrieval changes in the cognitive (WP1) and neural (WP2) expression of fear memory may serve as read-outs to demarcate the underlying processes necessary for memory reconsolidation. Second, in contrast to the immediate, but gradual decline of fear during traditional interventions, with memory reconsolidation the fear reduction is delayed, yet abrupt, and sleep may be essential (WP3). A thorough understanding of these processes is essential for developing a reconsolidation intervention in clinical practice (WP4). Finally, the program aims to understand the paradoxical dissociation, yet interdependence, between the cognitive and emotional expressions of fear memory (WP5). This proposal is unique in its bidirectional translational approach. It involves different levels of analysis: from behavioural science, to neuroscience to clinical science, and backwards.

Keywords: fear memory,memory reconsolidation,fear conditioning,fear extinction,fmri,sleep,anxiety disorders,ptsd,treatment for anxiety disorders
Ontology-based Knowledge Access for the higher education and research sector (OKHAERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 74000.0
EU funding (EUR): 74000.0
Participants: 1
Project status: CLOSED

The aim of the project is to design a system to support the knowledge base of SIRIS Academic S.L., a consultancy company specialized in higher education and research. With a PhD in Knowledge Representation and reasoning, and a knowledge of related state-of-the art tools, the Associate will be invited to apply the so-called Semantic Web and Ontology-based Data Access (OBDA) technologies for the integration of the HE&R knowledge corpus currently used by our consultants. This knowledge base should facilitate the organisation of the consultants' qualitative knowledge of the sector. It will be a tool to train future consultants, and - in connection with the open data query portal already developed by SIRIS - an instrument to enhance the quality of the consultancy. The Innovation Associate will work on the direct supervision of a senior consultant of the company, as well as a research specialised in KR and ontology. He/she is expected to a) get an in-depth knowledge of the current state of SIRIS's knowledge and tool to generate ideas of KM tools; b) implement a first prototype and get users' feedback; c) set up a plan to scale up the prototype at the level of the company.

Keywords: knowledge representation,knowledge management,higher education and research,semantic web and ontology based data access technologies obda