Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Trustworthy, Reliable and Engaging Scientific Communication Approaches (TRESCA)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Spain,Italy,Netherlands,United Kingdom
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2022-04-30
Duration (months): 28.0
Total project cost (EUR): 1199601.25
EU funding (EUR): 1199601.25
Participants: 6
Project status: CLOSED

The TRESCA Project focuses on developing trust in science and innovation through innovating communication practices between scientific researchers, journalists and policy makers. It does this by drawing on the expertise of a diverse set of partners, both scholars and practitioners, from multidisciplinary backgrounds. The project’s goals are to systematically understand what drives public trust in science communication through large scale, experimental survey research and qualitative, deliberative research. TRESCA is designed to build long-term impact and produce positive change through the engagement and training of stakeholders, including scientists, journalists, policy makers and the public, in order to increase the production, exchange and consumption of more trustworthy, reliable, and accurate scientific communications. TRESCA’s focus in doing this is unique. TRESCA foregrounds the communication of findings from Social Science and Humanities (SSH) research related to Science, Technology, Engineering and Mathematics (STEM) developments around digitalisation. As digital devices and services are ubiquitous and permeate people’s everyday life, TRESCA relies on visual communications to empower people with that knowledge which is relevant to thrive in the digital ecosystem. The project focuses on three areas of concern around digitalisation: misinformation and digital safety; environ-mental health; automation and the future of skills and work. TRESCA develops a set of tools for improving science communication including a tested and assessed animated science communication video; the prototype of a misinformation widget working on encrypted communication channels to help distinguish trustworthy contents and sources; and a Massive Open Online Course (MOOC) for scientists, journalists and policy makers to learn how to best facilitate reliable and trustworthy science communication.

Keywords: trust,digitalisation,social science,policy,journalism,disinformation,online media
Mechanoregulation of alternative splicing - a multi-omics and single cell approach to improved cardiac function (MERAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

To adapt cardiac function in response to mechanical load, a network of splice factors concertedly regulates multiple target mRNAs that affect biomechanics, electrical activity, metabolism, signaling, and growth. It includes the splice regulator RBM20, with mutations causing severe cardiomyopathy, as well as its substrate titin, whose >350 exons are differentially joined to adjust the elastic properties of the sarcomere and thus ventricular filling. In the spliceosome, diverse RNAs and RNA binding proteins interact in macromolecular complexes, but how their activity is regulated to adapt cardiac isoform expression and sarcomere mechanics has remained elusive. We have adapted localization proteomics to study macromolecular complexes in vivo at physiological expression levels, which has previously not been possible. Our titin-BioID knock-in mice have provided the first census of the sarcomeric proteome and uncovered a previously unknown connection between sarcomeric mechanotransduction and mRNA processing in the nucleus. This unexpected link is the basis of our hypothesis that altered strain of the titin filament is communicated to the nucleus where the spliceosome adapts titin isoform expression to adjust sarcomere elasticity. This proposed regulatory feedback loop would elegantly resolve the question of how sarcomeres adapt to mechanical load. Here, we will explore how the mechanoregulation of cardiac splicing contributes to heart disease in a functional multi-omics approach and develop technologies that combine single cell isoform sequencing and mechanics to examine how heterogeneity of the mechanical microenvironment determines isoform expression in the individual cardiomyocyte. The overall scientific goal of the proposed work is to investigate the functional interaction of two macromolecular machines – the sarcomere and the spliceosome – and to evaluate mechanotransduction as a potential therapeutic target in heart failure with increased ventricular stiffness.

Keywords: mechanotransduction,alternative splicing,biomechanics,sarcomere,localization proteomics,single cell multi omics,phenomics,heart disease
A high performance cost-effective MINFLUX microscope (PhaseFLUX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

MINFLUX is a novel super-resolution microscopy technology that localizes single fluorophores with extraordinary precision and enables structural imaging and single particle tracking with unprecedented spatiotemporal resolution. It can monitor conformational changes of proteins in living cells, which has the potential to revolutionize dynamic structural biology. Current MINFLUX microscopes however are complex and difficult to build, and the only commercial instrument is costly and has reduced functionality, thus access to this groundbreaking technology is limited. To enable widespread use of MINFLUX, we propose PhaseFLUX, a novel MINFLUX concept that reduces complexity by moving the zero position within the point-spread function, instead of physical movement. This innovative approach employs a fast variable phase plate consisting of only a few simple components, leading to significantly lower costs, higher robustness, and superior performance compared to existing instruments. Our project aims to develop a PhaseFLUX microscope prototype including 3D and multi-color capabilities. It will serve as a basis for potential commercialization, where the PhaseFLUX design promises reduced production and service costs, higher stability, higher performance and extended functionality. Building on our extensive expertise in super-resolution microscopy and collaborations with leading experts, we will focus on developing, validating, and demonstrating the PhaseFLUX prototype, paving the way for broader adoption and impactful biological discoveries. Additionally, we will analyze the intellectual property landscape to explore viable commercialization routes, ensuring this breakthrough technology benefits the wider scientific community.
Variational coarse-graining of lattice energies for crystal defects: Applications to partial dislocations and stacking faults (VarCrysDef)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Defects are omnipresent in crystalline materials and the understanding of their emergence and interaction is essential for the prediction of the macroscopic material behaviour. Thus, there is a huge interest to pass in a rigorous mathematical way from atomistic models for crystal defects to macroscopic models, e.g., for crystal plasticity. From a variational viewpoint this can be addressed by deriving effective limiting energies from lattice energies when the lattice spacing vanishes. A powerful method to carry out such a variational coarse-graining procedure is Gamma-convergence. In this framework we address here the variational coarse graining of lattice energies which capture the formation and interaction of defects of different dimension, namely partial dislocations and stacking faults. The splitting of dislocations into partial dislocations resulting in a stacking fault is a typical phenomenon of closed-packed crystalline structures. Thus, on the one hand we aim at proposing and analysing a suitable discrete model for partial dislocations and stacking faults in HCP, on the other hand we will embed this result into a broader context by investigating in a general framework the emergence of fractional vortices and string defects in XY-model type energies. Eventually, we will characterise geometric properties of minimisers for the coarse-grained energies.

Keywords: calculus of variations,gamma convergence,discrete to continuum variational analysis,dislocation models,vortex models
A novel multi-stage steam gasification and syngas purification demonstration plant for waste to hydrogen conversion (HYIELD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,France,Norway,Luxembourg,Switzerland,Germany
Call: Waste to Hydrogen demonstration plant (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 15472352.5
EU funding (EUR): 9999964.63
Participants: 18
Project status: SIGNED

Europe faces the joint challenge of decarbonising ever newer sectors and applications, whilst also seeking clean waste treatment and valorisation pathways. With over 300Mt of waste generated each year, Europe could produce up to 30Mt of clean hydrogen from waste to accelerate the decarbonisation of challenging sectors like aviation and heavy industry. However, exploiting this energy potential remains a challenge and so far, no robust and cost-effective solutions has been successfully commercialised. HYIELD aims to open a new low-cost pathway for clean hydrogen production and waste disposal. The project proposes a novel multi-stage steam gasification and syngas purification plant concept, which will efficiently convert different organic waste streams into hydrogen and is expected to achieve H2 99.97% purity and 62-74% energy conversion efficiency. The concept includes several beyond state-of-the-art innovations, including a novel process design, waste heat exploitation, Water-Gas-Shift membrane reactor, low-pressure metal hydride storage buffer and IA driven digital twin. The solution will be implemented at 3MW scale in a cement plant in Spain, where the hydrogen will be exploited for cement kiln firing. The demonstrator is expected to operate for 4,000h over a 15-month testing period with at least 10 different organic waste streams, treating over 3.9kt of dry material and producing 650t of hydrogen. It will also carry out the groundwork for up-scaling post-project locally and across the EU, working closely with industrial partners from the cement, steel, copper and gas sectors. It is forecasted that the solution will be able to deliver a Levelized Cost of Hydrogen of 2.19€/kg at industrial scale (20,000t/year waste treated), far below current electrolyser pathways (>5.5€/kg). The project is led by a consortium of Europe’s leading research groups, technology developers and industrial players in the hydrogen sector, from Spain, France, Germany, Norway and Luxembourg.

Keywords: hydrogen,renewable energy,gasification,circular economy,heavy industry,plasma,membrane separation,metal hydrade hydrogen storage,process engineering,digital twin,bioeconomy
Digital Mythology and Arabic Literature: A Digital Archive to Study the Dynamics of the Reception of Greek Myths in Modern Arabic Literature (DIGIMYTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Lebanon
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 282046.08
EU funding (EUR): 282046.08
Participants: 3
Project status: SIGNED

DIGIMYTH is an interdisciplinary project that adopts the tools of digital humanities (DH) in Arabic literary studies. It plans to create an open access digital archive through which it investigates the dynamics of the reception of Greek myths in Arabic literature produced in Egypt and in the Mashreq in the period 1850-1950. Thanks to its intersectional approach that involves DH, literary studies, historical and religious studies, the project aims at having an impact both on Arabic literary studies and on other fields of research. The general objectives of DIGIMYTH are to investigate how and when Greek myths were introduced into modern Arabic literature and to evaluate their impact on its development. The project envisages two primary specific objectives that address two main questions: 1) What are the modern Arabic literary texts containing references to Greek myths? The project plans to digitize relevant texts of Arabic literature that contain such references, and create an open access digital archive. This entails the application of IT tools to Arabic literary studies, which has made little use of digital research so far. 2) What are the dynamics of the reception of Greek myths in modern Arabic literature? While there are studies on the use of myth in Arabic poetry after 1948, they fail to determine the specific function of Greek myths, and to explain how these myths were integrated into the Arabic literary system before 1948. Resting on the data collected in the archive and on an interdisciplinary methodology that involves literary, historical and religious studies, DIGIMYTH aspires to answer the following questions: when and which Greek myths were introduced in Arabic literature? Is there any relation between the place and the reception of a myth, and between the latter and politics and ideology? How did the meaning of the myth change over time and space?

Keywords: modern arabic literature,greek mythology,translation,transmission,egypt,syria,lebanon,palestine,1800,1900,reception studies,world literature,digital humanities,digital archive
Promoting an environmentally-responsible Hydrogen economy by enabling Product Environmental Footprint studies (HyPEF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Coordination and support actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,Italy,Germany,France,Greece
Call: Product environmental footprint pilot for a set of FCH product categories (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1499431.25
EU funding (EUR): 1499431.25
Participants: 8
Project status: SIGNED

Fuel cells and hydrogen (FCH) systems are increasingly considered in energy and climate policies, roadmaps and plans all over the world. In order to avoid past criticalities, such as those leading to a climate emergency situation, sustainability criteria are being progressively implemented in these initiatives, e.g., by promoting low-carbon renewable hydrogen in Europe. In this regard, science-based criteria and procedures are required to guarantee the environmental suitability of FCH products, reporting their life-cycle environmental profile according to the principles of transparency, traceability, reproducibility, and consistency for comparability. While these principles are aligned with those of the general methodological guidance for Product Environmental Footprint (PEF) studies, further specification is required to effectively implement them when addressing FCH products. Hence, the HyPEF project aspires to support and promote the establishment of an environmentally-responsible hydrogen economy by developing and testing the first Product Environmental Footprint Category Rules (PEFCRs) specific to FCH products, while paving the way for subsequent related initiatives in the FCH sector. HyPEF is conceptualised as the natural step forward in methodological specification towards policy- and market-relevant life-cycle environmental assessment and benchmarking of FCH products. The interdisciplinary approach behind HyPEF leads to crucial advancements regarding (i) the first development and application of well-accepted PEFCRs tailored to three pre-selected FCH product categories (electrolysers for hydrogen production, tanks for hydrogen storage, and fuel cells for hydrogen stationary use), (ii) increased high-quality data availability for consistent environmental assessment and benchmarking of FCH products, and (iii) first PEF-oriented policy recommendations towards official qualification of an FCH product as an environmentally-responsible investment.

Keywords: category rule electrolyser life cycle assessment product environmental footprint stationary fuel cell tank
Horizon 2020 to Innovation Fund: up-scaling H2020 projects in the Energy Storage and Hydrogen sectors to the Innovation Fund (H2IF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Coordination and support actions
Countries involved: Belgium,France,Netherlands
Call: Support for the deployment of R&I results for climate mitigation. Synergies with the ETS Innovation Fund (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 1372061.61
EU funding (EUR): 999480.63
Participants: 7
Project status: SIGNED

The aim of this proposal is to promote and facilitate technologically, financially, and operationally mature projects from Horizon 2020 to reach deployment phase by means of developing synergies with the ETS Innovation Fund. The overall objective of H2IF is to validate such connection could be effective between promising Horizon funded R&I results and Innovation Fund for hydrogen and energy storage projects. This proof of concept will be made thanks to the scaling-up and submission of 3 projects to the Innovation Fund instrument, all of them having been selected due to their high ‘climate neutrality’ potential, their innovation degree, while already being supported by Horizon 2020.
Net-Zero self-adaptive activation of distributed self-resilient augmented services (NATWORK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,Spain,France,Italy,Switzerland,United Kingdom,Poland,Hungary,Belgium,Germany
Call: Reliable Services and Smart Security (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3828075.0
EU funding (EUR): 3628007.5
Participants: 15
Project status: SIGNED

The ambition of the NATWORK project is to set the foundations and deploy the very first economically realistic, energy efficient and viable bio-inspired AI-based 6G cybersecurity and resilience framework for intelligent networking and services, taking a holistic approach and considering all elements in a cross-sector business environment to address the diverse requirements and challenges that arise. The NATWORK project aims to develop a novel AI-leveraged self-adaptive security mechanism for 6G networks based on resilient bio-mimicry principles. The goal is to improve the malleability and the self-resilience of future 6G network ecosystems to offer augmented and secure services at the lowest energy costs. The principle premise is to empower various entities of 6G ecosystems with the ability to self-regulate their conditions to provide service continuity in compliance with service SLAs. The Secure Federated Learning architecture of NATWORK will be based on decentralized defensive AI models embedded in dis-aggregated 6G network physical layer, smart Edge Network Interface Cards and RAN devices with P4-based programmable data plane and advanced DPU acceleration, with local feature extraction at wire-speed and AI model training. Among the key 6G security challenges that NATWORK aims to alleviate are Moving Target Defense and adaptive response to incidents, the employment of Net Zero AI and energy-efficient security for sustainable networks, the Detection of new forms of attacks bearing deep control flow monitoring as well as the elaboration of a continuum of security for payload deployment fostering secure migration of novel forms of in-network operations and secure distributed computations.

Keywords: 6g network,6g cybersecurity,ai,self resilient networks,anti jamming