Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creating an Infrastructure for the Numerical Exploration of Metallurgical Alloys (CINEMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Manufacturing has considerable economical, technological, and environmental importance at the global scale, impacting fields such as transportation, energy, safety, and healthcare. Materials innovation has long relied on costly and ineffective trial-and-error experiments. Meanwhile, computational routes face challenges due to the multidisciplinary and multiscale aspects of linking materials processing, microstructure, and ultimately properties. By building an infrastructure for computational exploration of alloys, this project will put together foundations for computational discovery of structural materials, e.g. by means of high throughput and machine learning methods, which could lastingly change the way we approach metallurgical innovation. The project will bring together two complementary sets of skills, with a researcher expert in linking materials processing to microstructures, and a supervisor expert in predicting the mechanical behavior of complex microstructures. While adding an essential piece of competence to the host institution, the project will support the growth of the candidate as he aims at building a world-class research group in Europe. He will also gain key skills in software development, and a number of management and transferable skills with the support of award-winning management and human resources personal (monitored through detailed plans for career development, data management, and exploitation, dissemination, and communication of results). The impact and reach of the action will be maximized. First, by openly distributing all major components of the computational framework. Then, with scientific publications in high-impact scientific journals, as well as a broad range of outreach activities in the form of publications in non-technical outlets, reach out events to young and non-technical audiences, while ensuring accessibility to the widest possible audience (e.g. through commitment to international accessibility standards).

Keywords: computational modeling,physical metallurgy,solidification,crystal plasticity,computational homogenization
Using PML nuclear body biology to identify potential AML treatment targets (PMLingAML)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-17
End date: 2022-12-16
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Understanding the initiation and development of acute myeloid leukemia (AML) represents an important challenge which may lead to the identification of new therapeutic strategies. Acute promyelocytic leukemia (APL) was formerly the most lethal subset of AML; however, today the vast majority of APL patients can be cured by combination therapy. Therefore, fully understanding the mechanisms underlying successful treatment, by analysing the biology of APL pathogenesis will assuredly improve the management of AML subsets associated with a poor outcome, such as NPM1-mutated AML. Using a novel knock-in mouse model, PmlC62A/C65A, which mimics Pml nuclear body (NB) disruption induced by the main oncoprotein PML-RARα in APL, we have previously shown that Pml NBs are essential in APL pathogenesis and treatment response. Our project “PMLingAML” aims to carry on elucidating the impact of Pml NB disruption in APL, and then to apply this knowledge in other AML subsets. To this end, a mass spectrometry analysis will be conducted on both hematopoietic stem and progenitor (LSK) cells and promyelocytes isolated from healthy and leukemic murine bone marrows, to decipher the consequences of Pml NB disruption on the SUMOylome. Next, since PML NBs and NPM1 share common cellular functions and characteristics, we will analyse the inter-relationship between them; their localisation and dynamics will be assessed according to their respective status (disruption, mutation, knock-out), for example by high resolution imaging, both in various healthy and leukemic mouse models (incl NPM1c+ and NPM1c+/FLT3ITD), and in patient samples. Their respective roles in response to a drug under clinical trial, Dactinomycin, will also be scrutinised. Finally, as DNA damage repair is an important function disrupted during leukemogenesis, the roles of Pml NBs and Npm1 will be assessed together with their inter-relationship, with particular focus on the base excision repair (BER) pathway.

Keywords: leukemia,post translational modifications,mouse models,therapeutic targets,pml nuclear bodies,npm1,sumoylome
EMOTIONS FIRST. Feeling reason: the role of emotions in reasoning (EMOTIONS FIRST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

‘Emotions First’: Neuroscientists have recently discovered the primacy of feelings and emotions over reasoning, in our mental life. On the basis of these results, cognitive scientists are developing a semantics of conceptual classification, grounded on feelings and emotions towards the world. My work for the Marie Curie aims to show that the ancient Greek philosophers developed theories of action, where the battle between our desires and feelings towards the world grounded the pattern of rationality that emerged from this battle. On my reading of ancient philosophy – primarily Plato, Aristotle and the Stoics – the process of reasoning arises from a calculus of feelings and emotions (culminating in love), which aim towards the organism’s good. Socrates held that every human has an innate desire for his or her own good; the human organism struggles to find the good, guided by the desires of the soul. Plato and Aristotle saw the human soul as a locus of desires and motivations, whose contest constitutes deliberation for the good. For both philosophers, the soul’s competing motivations and feelings towards the world result in pleasure, if the competition outcome is successful, and in pain, if not. The successful competition is reasoning, the unsuccessful, miscalculation. I aim to investigate the hypothesis that ‘the emotional quest for the good of the organism is constitutive of rationality’ in an international research-hotbed of ‘emotions in reasoning’, at the Philosophy Centre of Edinburgh University, where philosophy meets cognitive science on ‘emotive lateral thinking’ and on the ‘extended knowledge hypothesis’. The training I can receive at this Center will empower me to present in the best theoretical framework the ancients’ intuition that the calculus of feelings can shed light into the origins of rationality. This is my ambition for the Marie Curie Fellowship.

Keywords: philosophy of emotions,ancient greek philosophy,decision making,education
Angular studies of photoelectrons in innovative research environments (ASPIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Germany,Italy,Germany,France,France,France,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3180705.84
EU funding (EUR): 3180705.84
Participants: 15
Project status: CLOSED

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the “molecular frame” (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by “illuminating the molecule from within”, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the development of novel instrumentation in the future.

Keywords: photoelectron,synchrotron,free electron laser,charged particle detection
Balancing the immune response in cystic fibrosis: using zebrafish models of infection and inflammation to uncover new therapeutic approaches (CFZEBRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Chronic pulmonary infections accompanied by persistent neutrophil-dominated inflammation result in severe progressive lung injury and are the leading causes of morbidity and mortality of CF patients. In addition to known mucociliary defects, several lines of evidence suggest primary alterations in innate immune responses contribute to CF pathology. Currently, our understanding is limited by the lack of suitable animal models that recapitulate immune abnormalities found in CF patients. To address these unmet needs, I propose to develop zebrafish larvae as a tractable animal model to investigate the role of CFTR in regulating inflammation and infection. In preliminary data, reduced zebrafish cftr expression is characterized by more inflammation and increased susceptibility to infection with CF pathogens. In this fellowship, I will use this innovative model to recapitulate aspects of the CF microenvironment. Using innovative genetic techniques combined with dynamic imaging, I will elucidate physiological functions of CFTR in innate immune pathophysiology in CF and identify new therapeutic molecules active in a CFTR-deficient context to balance infection and inflammation to benefit patients with CF. Finally, I will confirm my findings in human CF macrophages. Using larval zebrafish gives a unique insight into immune cell function in CFTR deficiency. This will help guide future therapies aimed at correcting the innate susceptibility of CF patients to infective and inflammatory lung disease, with consequent improvement of their life quality and expectancy.

Keywords: cystic fibrosis,inflammation,infection,zebrafish,anti inflammatory therapy
Skill development and firm upgrading to sustain the competitiveness of the EU manufacturing sector (SkillUp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-18
End date: 2017-09-17
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In the last decades, European manufacturing has been the object of an intense reorganisation driven crucially by multinational firms’ offshoring strategies that have led to the emergence of global production networks. European companies have mainly devoted their efforts to presiding over high value-added upstream and downstream activities whilst offshoring low value-added operations to low labour cost economies. The hollowing out of manufacturing activities is impacting on the EU labour market: it affects the demand of jobs in the EU, and the local and regional stock of competences, raising concerns over a mismatch between firms’ skill needs and persistent skill shortages. The aim of SkillUp is to explore routes that combine firms’ upgrading strategies with workforce skill development in order to enhance the competitiveness of EU manufacturing industries. SkillUp focuses on: 1) which skills are needed for the jobs of today and tomorrow: in which industries? in which regions? 2) are these skills available and where can they be found? and 3) how should such skills be created and what training/education needs to be put in place for this be achieved? Long term European socio-economic growth rests of maintaining a competitive manufacturing sector necessarily in high value added industries, and SkillUp will identify the appropriate sets of skills needed to meet firms’ demand and enhance EU manufacturing competitiveness. The study will use a mixed method research: 1) inferential statistics (t-test) on the EU labour participation using EU Labour Force Survey; 2) a multiple case-study approach by collecting primary through firm-based interviews and secondary data from company reports as well as industry and regional aggregate data from Eurostat and the Labour Force Survey; 3) Fuzzy-set Qualitative Comparative Analysis - Boolean algebra and set theory - will be applied to detect interaction effects amongst firms’ upgrading strategies and workforce skill development.

Keywords: workforce skill development,firms upgrading strategies,global value chain,manufacturing sectors,education and training policies
Towards the Photonic Solar Cell - In-Situ Defect Characterization in Metal-Halide Perovskites (PhotSol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Mitigating climate change is one of the key challenges of this century. This concerns in particular the fossil fuel-based energy sector as also stated in the H2020 topic “Secure, clean and efficient energy”. Harnessing solar energy by photovoltaics (PV) is the most promising way towards a decarbonized society. However, efficiency and costs of conventional solar cells are still hampering their broad application. Recently a novel type of solar cell appeared based on metal-halide perovskite. Due to versatile and simple manufacturing methods, its unique optoelectronic properties and high electronic quality, this material has the potential to revolutionized PV by a unique combination of low-cost and high efficiency. However, there are still loss mechanisms present that need to be understood and eliminated to make this technology really a breakthrough compared to conventional PV. This project addresses these losses, which are caused by defects (such as grain boundaries, interfaces to contact materials, and impurities) by a combination of in-depth optoelectronic and high-resolution structural characterization. The aim is to reach a completely novel operation regime, the “photonic solar cell”, which is at the same time a perfect light emitting diode. This is highly exciting from the physics point of view and directly relevant for application, because performance is increased. Furthermore, the obtained understanding of the defect physics will enable increased long-term stability (one of the major challenges) and accelerate the development of non-toxic lead-free perovskite materials. This work is timely because trial-and-error engineering approaches, which were applied so far, have come to their limits. On the other hand, just now the quality of the ultrathin films used in the solar cell is sufficient to perform in-depth device physics studies, where I am an expert on. Performing and leading this study at LMU will pave the way towards my complete scientific independence.

Keywords: perovskite solar cells,recombination,defect physics
Dynamic regulation of tissue response by matrix viscoelasticity (VISCOMATRIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1499989.0
EU funding (EUR): 1499989.0
Participants: 2
Project status: SIGNED

The mechanical properties of the extracellular matrix (ECM) regulate processes during development, cancer and wound healing. The vast majority of research efforts in this field have been focused on ECM’s elasticity as a leading determinant of cell and tissue behaviour. However, the ECM is not merely elastic but is instead both viscous and elastic. Due to its viscoelastic nature, the ECM response to mechanical loads is inherently dynamic and evolves with time, independently of matrix degradation or remodelling. Despite the universality of ECM’s viscoelasticity, how viscoelasticity affects tissue function is unknown. Based on our preliminary data, cellular behaviour diverges significantly between viscoelastic and elastic ECMs. We hypothesize that viscoelasticity dominates tissue response. Our objective is to determine the biophysical and molecular mechanisms that regulate viscoelasticity sensing and mechanotransduction in 3D and understand its implications in cell and tissue response. To address, we will use an integrative approach that will combine 3D materials with exquisite control of viscoelastic properties, systematic molecular perturbations, computational modelling and precise quantitative analysis of cellular properties, forces and stresses. While using these tools, we will unravel the molecular mechanisms that regulate viscoelasticity response at single-cell and collective level. We will determine the dynamic role of viscoelasticity in breast homeostasis, malignant transformation and invasion. Finally, we will validate the implications of viscoelasticity by measuring breast ECM’s viscoelastic properties and with in vivo experiments. We expect that this project will unravel novel mechanosensing mechanisms operating at the roots of biological responses. These mechanisms, due to the inherent viscoelastic nature of tissues, will affect many biological fields from morphogenesis to cancer, and applied fields such as tissue engineering and biomaterials design.

Keywords: mechanotransduction,mechanosensing,cell mechanics,extracellular matrix,biomaterials,bioengineering
ALPS Consortium KAM and Enhancing Innovation Management Service 2014 (ALPSKAM14)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Italy
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 83070.0
EU funding (EUR): 66456.0
Participants: 4
Project status: CLOSED

In the 3 regions covered by ALPS EEN Consortium (Piemonte, Liguria and Valle d’Aosta), the project will provide a new service enhancing the innovation management capacity of SMEs to two specific groups of SMEs: - Beneficiaries of the SME Instrument - SMEs with significant innovation activities and a high potential for internationalisation. The main goal of the project is to support SMEs innovation management capacity; a seven-day service package will be provided to them, regardless of the belonging to the first or second specific group. The Action will generate the provision of 35 service packages: 1 for Valle d'Aosta, 26 for Piemonte, 8 for Liguria, in coherence with the economic weight of the covered regions. Services to be provided: 1. Providing Key Account Management services to beneficiaries of the SME Instrument Phase one: The packages delivered will depend on the success rate in the SME Instrument Phase 1. As phase 2 will not be covered throughout 2014, it is reasonable to deliver more service packages to innovative companies (point 2). 2. Providing audits to selected SMEs with significant innovation and a high potential for internationalisation with the aim of enhancing their innovation management capacities. According to the potentiality of the SMEs located in the ALPS Regions, targets are: 4 packages for KAM Services 31 packages for “Innovation Management” Services Relation to the Work Programme: 1. Lack of innovation management capacity is recognised as an important barrier to creating economic impact from innovation activities in SMEs: the project aims at providing focused consulting services enhancing the SME innovation management capacity. 2. The assessment will be based on the IMP³rove methodology The project is embedded in the ALPS EEN consortium, which will drive and support with complementary services the development of the Action. 4 ALPS EEN partners will allocate 4 senior experts whose total engagement will be over 12 person/month.

Keywords: innovation management,project management,sme instrument,h2020,competitiveness enhancement