Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reconstructing the Phillipps Manuscript Collection: using Linked Data technologies to analyse the creation and dispersal of a major European cultural heritage collection (PHILLIPPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-05-12
End date: 2016-05-11
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

This project aims to test and evaluate the value and applicability of innovative e-research methodologies in an important and significant field of cultural heritage research: the history and transmission of cultural objects between different collections and owners over many centuries. This analysis will focus on reconstructing the Phillipps Collection: a now-dispersed 19th-century collection of about 60,000 European manuscripts. The significance of the Phillipps Collection for the history of medieval and early modern manuscripts is incalculable. Phillipps helped to ensure the survival of a large number of manuscripts which might otherwise have been lost. Through its sale and dispersal, the collection enriched the holdings of institutions in many countries and made this manuscript heritage accessible around the world. There are significant groups of former Phillipps manuscripts in England, Wales, France, Belgium, Germany and the United States. These manuscripts are now the object of research by a wide variety of different disciplines, including literature, history, art, philosophy, music, linguistics, and law. This project will assemble and analyse a large body of data relating to the history of this corpus of manuscripts over many hundreds of years. Linked Data technologies and standards will be used to express this information in the form of a network of relationships which can serve as the basis for statistical analyses and graphical visualizations of the history of the collection as a whole and the individual objects in it. The project aims to address two main research questions: • The applicability and value of Linked Data technologies as a methodology for the large-scale analysis of the history of cultural objects and collections; • The history and significant characteristics of the transmission of a major group of European medieval manuscripts between collections and collectors over the centuries.

Keywords: medieval manuscripts,history of cultural collections,linked data,digital humanities
Elucidating the enigmatic role of nuclear actin in genomic stability (NUCLEAR ACTIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-08-01
Duration (months): 24.0
Total project cost (EUR): 207928.8
EU funding (EUR): 207928.8
Participants: 1
Project status: CLOSED

Nuclear actin-related proteins (ARPs) are stoichiometric subunits of chromatin remodelers and specifically recognize and bind to (modified) histone proteins. In the case of the chromatin modifiers INO80, SWR1 and NuA4, canonical monomeric actin is also an important constituent of these large macromolecular complexes and actively takes part in the remodeling reaction. The main characteristic of actin, however, is its dynamic nature and its capacity to form polymeric actin filaments, which is tightly regulated by a plethora of actin binding proteins amongst them also nuclear ARPs. Interestingly, alteration of actin levels strongly sensitize cells to DNA damage in an enigmatic process and the chromatin-binding nuclear ARPs are obviously strong candidates that possibly couple actin homeostasis in the nucleus with a putative role in genomic integrity. Missing from the field is a genetic approach to specifically mutate actin in the chromatin modifier context and to analyse the impact of polymerization mutants in genomic integrity. The central hypothesis in this research proposal is that nuclear ARP/chromatin remodeler associated actin is a key mediator in genomic maintenance. This assumption is based on the very recent finding in the Gasser laboratory that interference with actin homeostasis renders cells to be hypersensitive to genomic insult as chromosomes are rapidly fragmented in presence of actin depolymerizing agent Latrunculin A and DNA damaging agent zeocin. The major challenge in this project is to bypass the paramount role of actin in the cytoskeleton and to focus on the fraction of nuclear ARP associated actin. This will be achieved by genetically replacing nuclear ARPs with ARP-actin fusion constructs in the budding yeast S. cerevisiae, which will allow me to introduce actin mutants exclusively in a chromatin modifying context. Concomitantly, a new approach to generate actin probes for microscopy based on bicyclic peptides will be applied.

Keywords: actin regulation,chromatin remodelers,nuclear actin-related proteins,genomic stability,yeast genetics,in vivo microscopy
Cultural Defense of Nations: A Liberal Theory of Majority Rights (CULTURAL DEFENSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 216952.8
EU funding (EUR): 216952.8
Participants: 1
Project status: CLOSED

Immigration has become a hot-button issue that stands at the forefront of public debates. This project addresses a simple but important question: Is it legally and morally defensible for a liberal state to restrict migration in order to preserve cultural rights of a majority group? This question is one of the greatest challenges facing liberalism today. It is fiercely debated in the U.S. Congress, EU institutions, and international organizations. "Cultural Defense" discusses the justifications and limits of cultural rights of majority groups from a liberal perspective. On the whole, it accepts that some cultural restrictions on migration can be legitimate, but only if culture is defined very narrowly. The project constructs a liberal theory of the right of a majority to preserve fundamental essentials of its culture—its Britishness, Frenchness, Germanness, etc.—without recourse to the draconian measures recently adopted in several states. In so doing, the project attempts to square the circle; it provides a new theory in which liberal states can welcome migrants without dramatically changing the cultural makeup of their society. The project contains five parts. The first characterizes contemporary patterns of global migration and shows that it presents a new challenge. The second finds that, as a result, liberal states have become obsessive with their national culture. Citizenship is undergoing a process of "cultural convergence" under which liberal states define the essence of their citizenship, and thereby the rules of joining the community, in cultural terms. The third describes why this process embraces illiberal policies that violate the same values it seeks to protect. The fourth sets out a liberal theory of cultural defense, exploring its justifications and boundaries in human rights law and moral philosophy. The fifth part develops a workable metric—termed "National Constitutionalism"—distinguishing legitimate cultural restrictions from illegitimate ones.

Keywords: immigrant integration,citizenship tests,constitutional identity,constitutional patriotism,loyalty,cultural exclusion
Multiple sensor fault tolerant control for management of interconnected, nonlinear systems (FUTURISM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

This project deals with the problem of fault tolerant control (FTC) for the management of interconnected, nonlinear systems affected by multiple sensor faults. Sensor faults are of paramount importance due to the large number of sensors used for a) monitoring and control of large-scale systems (e.g. transportation systems, energy and power systems), and b) providing rich and redundant information for executing safety-critical tasks (e.g. aerospace systems, petrochemical processes). The number of sensors is expected to increase in the way of creating smart cities, a societal challenge of European Union. To this end, Europe 2020 strategy has set as key priority the enrichment of digital society that will provide `intelligence’ to a conventional city, using information and communication technologies integrated with sensors and sensor networks. This project proposes a methodology that can contribute in the reliability of these means, the safe system functioning and the protection of everyday life. The novelty of the proposed FTC method lies in its capacity to handle multiple sensor faults, and furthermore to compensate their effects on interconnected, nonlinear systems. This is realized by deploying a large number of agents in a non-centralized architecture, important for FTC in large-scale systems. The FTC is conducted based on the decision of a multiple fault diagnosis (MSFD) mechanism designed to detect and isolate multiple sensor faults in interconnected, multisensory controlled systems. Given that multiple sensor FTC can be significantly affected by the substandard performance of the MSFD mechanism and the network imperfections of the agent’s communication, derived methods will be supported by MSFD guarantees and communication protocol will be designed to manage communication problems. The strong experience of the fellow in MSFD of interconnected, nonlinear systems and supervisor’s expertise in multi-sensor FTC can ensure the success of this project.

Keywords: fault tolerant control,fault diagnosis,sensor faults,nonlinear systems,interconnected systems
Integrative strategy for the development of urinary bladder analogs (REBTX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-12-05
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

The current treatment of bladder defects is often associated with high site morbidity and patient discomfort. The therapeutic standard methods, involve the use of materials with low biological performance and lack in replicating the bladder’s anatomical structure. Regenerative Bladder Therapy (ReBTx) aims in addressing the reconstruction of the bladder by using an innovative bottom-up approach, to recreate the physiology of the bladder tissue. In a first stage, a 3D network based on a functionalized hydrogel will be developed to allow the cellular growth and protrusion of blood vessels. Then, the optimized gel, with or without cells, will be incorporated within a porous collagen-based scaffold that will offer mechanical support and guidance for tissue regeneration. The ReBTx constructs will be tested in in vivo settings to properly evaluate the construct integration, recruitment of blood vessels and function acquisition. The transition from fundamental research (in vitro optimization) towards clinical application (in vivo) will render the possibility to address the complex mechanism involved in bladder regeneration. The potential towards patenting and commercialization will be closely taken under consideration, due to the bench-to-bed side aspect of the ReBTx proposal and the intimate collaboration between several high ranked groups at Radboud University (NL) and entrepreneurial entities (NovioTech, BV and EMCM, BV, NL). Eventually, ReBTx could be implemented to significantly improve the patients’ quality of life. The multi-facetted sides of the ReBTx approach enable the use and acquisition of an extensive knowledge and experience in tissue engineering concepts, equipping the applicant with solid managerial, social, and scientific skills that will pave the path towards the development of a scientific career. Even more, the use of a clinical setup will equip the candidate with practical and conceptual tools for translational aspects of tissue engineering.

Keywords: urinary bladder,tissue engineering,vascularisation,blood vessels,smart hydrogel,3d scaffolds,biocompatible systems,stem cells,adipose-derived stem cells,animal models,commercialization
Molecular Mechanisms Employed by the Newly Assigned RNA-binding Protein FASTKD2 (MOMEFAST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Posttranscriptional gene regulation is an essential process exerted by a multitude of RNA-binding proteins (RBPs) and allows for rapid adaptation of the cellular proteome to environmental perturbations. Previously, only in a limited number of instructive cases, the RNA networks targeted by individual RBPs had been elucidated. The recent proteome-wide unbiased identification of RBPs yielded a comprehensive catalogue of RBPs acting in human cells and has assigned an RNA-binding activity to over 300 orphan proteins, however without revealing their biological function. FASTKD (FAS-activated serine/threonine kinase domain-containing) proteins constitute an entire family of newly assigned RBPs with poorly defined functions and lack classical RNA binding domains. A loss of function mutation within FASTKD2 has been associated with a lethal form of infantile encephalomyopathy. FASTKD2 localizes to mitochondria and appears to regulate mitochondrial homeostasis by entirely undefined mechanisms. To address to which extent and how RNA binding contributes to the evidently vital functions of FASTKD2 I will extensively characterize the FASTKD2-RNA interface. I will determine the regions of FASTKD2 that interact with RNA making use of a novel and unprecedented technique termed RBDmap. The results of this analysis will guide systematic tests of RNA binding mutants of FASTKD2 in RNA interference based complementation assays. To obtain a comprehensive picture of the factors mediating the effects associated with a loss of function of FASTKD2 I will analyze the network of proteins and RNA motifs associating with FASTKD2 at the systems level. The models derived from the obtained data will be validated in cell-based assays. The required interdisciplinary approach is unique and will yield valuable insights into the molecular actions and interconnections of an entirely new type of RNA binding proteins in mitochondrial homeostasis in health and disease.

Keywords: rna binding proteins,rna biology,fastkd proteins,rap domain,mitochondrial homeostasis,cytochrome c oxidase,molecular mechanisms
Towards the simulation of breast surgical lumpectomy and surgery planning through an isogeometric numerical analysis approach (IBESUP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Breast cancer is currently the most prevalent form of cancer affecting women all around the world. The treatment of early stage breast carcinoma involves either lumpectomy followed by radiotherapy or mastectomy. In the former case, only the tumour is removed but asymmetry and distortion of patient's breast may occur. To date, there are no tools that can accurately predict the cosmetic outcome of lumpectomy or breast augmentation surgery, which is to a large extent dependent upon the surgeon's experience and subjective judgement and, therefore, the result of such intervention procedures cannot be fully guaranteed. Thus, there is an acute need for a pre-surgical methodology that could provide both valuable information to the surgical team on pre-operative planning and guarantee a successful cosmetic outcome for the patient. The present proposal aims to develop an efficient and accurate numerical tool for realistically simulating oncoplastic breast surgery. The proposed numerical procedure will be based on the newly established Isogeometric Analysis methodology, in order to simulate the mechanical behavior of breast tissues that undergo large deformations during the incision, excision and wound healing process of standard lumpectomy surgery, as well as in breast augmentation with prosthetic implants. To this end, the proposed numerical procedure will be capable of incorporating patient-specific breast geometries obtained, in the initial development phase, through magnetic resonance imaging. As a result, it is expected that the proposed computational framework could assist surgeons in breast surgery pre-operative planning, while providing them with a valuable tool for the cosmetic outcome assessment.

Keywords: bioengineering,computational mechanics,surgical planning,breast cancer,isogeometric analysis,finite element method
Multi-cellular hybrid bio-MEMS (PHANES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 440785.0
EU funding (EUR): 440785.0
Participants: 1
Project status: CLOSED

The main goal of this project is the fabrication and assembly of pluri-cellular hybrid bio-MEMS by manipulation with optical tweezers aiming to produce highly bio compatible and autonomous micro systems.

Keywords: mems,hybrid systems,biotechnology
Effect of Physical Activity in Pregnancy on Maternal and Fetal Human Milk Oligosaccharides (HMO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 186783.6
EU funding (EUR): 186783.6
Participants: 1
Project status: CLOSED

The project proposed by the fellow Evelyn Jantscher-Krenn and the scientist in charge, Gernot Desoye, Medical University of Graz, Austria, aims at pinpointing the potential role of Human Milk Oligosaccharides (HMO) as biomarkers in metabolic diseases in pregnancy. HMO are immunomodulatory glycans in breast milk that are also present in the systemic circulation of pregnant women. New evidence detecting HMO in the umbilical cord blood (fetal circulation), raises the question whether prenatal HMO can influence pregnancy outcomes and developmental programming of the fetus. In breast milk, HMO concentration and composition are dependent on genetic, but potentially also environmental factors. We therefore hypothesize that prenatal HMO have an impact on the health of mother and fetus, and are correlated with life-style induced metabolic changes. To test the hypothesis, three project objectives are formulated: Objective 1 longitudinally determines maternal HMO concentration and composition in serum to describe variability and temporal changes during pregnancy. Objective 2 determines fetal HMO concentration and composition in arterial and venous cord blood, in comparison to maternal HMO, to gain insight about origin. Objective 3 investigates associations of prenatal HMO (maternal/fetal) with both, maternal factors (maternal body mass index and physical activity) and fetal outcomes (fetal growth and body composition). Biological specimens for HMO analysis and data for objective 3 will be available through an existing cohort study. For the implementation of this IIF, the fellow will transfer HMO analysis methods from the University of California, San Diego, USA, and combine this knowledge and technology with expertise in Perinatology at the Medical University of Graz. As such, the project will contribute to establishing the emerging field of HMO research in Europe and form the basis for the fellow’s career vision of pioneering the field of HMO in Perinatology.

Keywords: human milk oligosaccharides,pregnancy,physical activity,obesity,developmental origin of health and disease,fetal growth,body composition,association studies