Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Consent in a Trial and Care environment (CONTRACT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Coordination and support actions
Countries involved: Germany,Belgium,Belgium,Greece,Germany
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 581792.4
EU funding (EUR): 499235.0
Participants: 5
Project status: CLOSED

CONTRACT is about consent. The project focuses on analysing how the legal (and underlying ethical) concepts of informed consent in the European Data Protection Directive and in the Clinical Trials Directive have had and continue to have an impact on the success of translational research. The project predominantly deals with vulnerable patients as their consent is of utmost complexity. The concept of informed consent in the two mentioned Directives will be analysed from a legal, ethical, IT-related and clinical point of view. The European approach on the matter will be compared with national concepts of informed consent for care purposes in the Member States. CONTRACT will support the European Commission and other policymakers in achieving a clear Community framework by providing clarity on different concepts of informed consent on European and national level. CONTRACT’s approach will be based on facts and figures by delivering an empirical survey about the handling of consent in European and national translational trials. CONTRACT will identify good practices in obtaining and administering informed consent in translational research and will give recommendations on possible harmonization of and common approaches to the legal framework. CONTRACT has already built a target community for its services, the “partner projects”, which will be significantly enlarged after the project’s start. CONTRACT will offer a help desk for its target audience on consent issues and will constantly support partner projects and other relevant stakeholders in balancing patient’s and research interests by a proper management of consent. In achieving these objectives the project has put together an internationally recognised interdisciplinary team of individuals and organisations with significant expertise and know-how on all areas of relevance to the project, it has drawn-up a ambitious – yet achievable - workplan, and has made every effort to identify and minimize potential risks.

Keywords: informed consent,data protection,clinical trial. data protection directive,clinical trials directive
Vector-borne Risks for Europe: Risk assessment and control of West Nile and Chikungunya virus (VECTORIE) (VECTORIE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,France,Hungary,Germany,France,Latvia,Switzerland
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2010-11-01
End date: 2014-01-31
Duration (months): 39.0
Total project cost (EUR): 3791100.0
EU funding (EUR): 2784402.0
Participants: 9
Project status: CLOSED

VECTORIE provides for a multidisciplinary approach combining the expertise of (basic) virology, entomology and advanced vaccinology to monitor the spread of and diagnose, prevent and treat infections caused by West Nile virus (WNV) and Chikungunya virus (CHIKV). VECTORIE therefore addresses Europe’s need to prepare for these vector-borne diseases along three strands: Vector biology: WNV and CHIKV are emerging mosquito-borne viral diseases. Generating novel knowledge on avian and mammalian host susceptibility and vector competence of the two main vectors of WNV and CHIKV, will lead to important insights necessary for determining the type of surveillance system appropriate for European countries to detect and predict emerging WNV and/or CHIKV outbreaks. Virulence & pathogenesis: VECTORIE addresses the need for understanding how CHIKV and the four WNV lineages circulating in Europe differ in their capacity to cause neuroinvasive disease. These studies will improve Europe’s ability to monitor the spread of these infections and will lead to diagnostic and prognostic tools as well as novel intervention strategies. Vaccination strategies: The severity of WNV and CHIKV neuroinvasive disease, the long term sequelae reported from infected individuals and the negative impact of these infections on the blood transfusion system collectively justify the development of safe and effective vaccines against these infections. VECTORIE brings together a platform of technologies using either virus-like particles or Modified vaccinia Ankara vaccine candidates, for the development of novel mono- and bivalent vaccine candidates against WNV and CHIKV. VECTORIE’s integrated approach will largely contribute to adequate risk assessment and risk mitigation of the emerging health threat caused by WNV and CHIKV infections in Europe.

Keywords: vector west nile virus chikungunya prevention vaccine birds crows mosquitos mice patients
Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services (EUROGENTEST2)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Coordination and support actions
Countries involved: Belgium,United Kingdom,Finland,Netherlands,Ireland,United Kingdom,France,United Kingdom,Switzerland,Sweden,Netherlands,Spain,Germany,Germany,Netherlands,Czechia
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-01-01
End date: 2013-12-31
Duration (months): 36.0
Total project cost (EUR): 2245003.48
EU funding (EUR): 1996989.0
Participants: 22
Project status: CLOSED

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe. This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the targets for laboratory and health professional accreditation, by contributing to guidelines and standards, and actively interacting with the professional organizations and the policy makers. EuroGentest2 will also assist the diagnostic and clinical community and the individual laboratories and counselling units in reaching those aims by providing tools for quality management and by coordinating training activities. EuroGentest2 will extend its activities from postnatal diagnostic and predictive testing to prenatal testing, thereby building on the achievements of the FP6 SAFE network, and to direct to consumer testing. A major aim of the Coordination Action will be the creation of a European association of genetic diagnostic centres that will guarantee the future of the network. The Coordination Action will lead to the further harmonization and quality assurance of genetic practice. The patients will benefit by the improvement of the analytical and clinical quality and validity of the testing, and from improved trans-border services and information. The European diagnostics industry will benefit through a faster access of innovations to the market through the validation for diagnostic use. It will enable countries and regions with less developed health care infrastructure to develop standards for best practice of provision of clinical genetic service. The Coordination Action will also identify research needs and have the capacity to set a research agenda that corresponds to the needs of the human genetics community

Keywords: genetic testing,harmonization,quality management,proficiency,prenatal diagnosis,rare diseases
GRID INITIATIVES FOR E-SCIENCE VIRTUAL COMMUNITIES IN EUROPE AND LATIN AMERICA (GISELA)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Spain,Uruguay,France,Mexico,France,Italy,Chile,Brazil,Venezuela, Bolivarian Republic of,Colombia,Portugal,Ecuador,Panama,Cuba,Argentina,Peru
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 2755842.0
EU funding (EUR): 850000.0
Participants: 20
Project status: CLOSED

The GISELA objective is to guarantee the long-term sustainability of the European – Latin American e-Infrastructure and thus ensure the continuity and enhancement of the Virtual Research Communities (VRC) using it. The project will focus on: • Implementing the Latin American Grid Initiative (LGI) sustainability model rooted on National Grid Initiatives (NGI) or Equivalent Domestic Grid Structures (EDGS), in association with CLARA and collaborating with EGI; • Providing VRCs with the e-Infrastructure and Application-related Services required to improve the effectiveness of their research, addressing both: o Current EELA-2 small User Communities; o Larger VRCs through “Specialised Support Centres” (SSCs). The GISELA mission is twofold: - Ensure the sustainability of the EU-LA e-Infrastructure The sustainability of the EU part of the e-Infrastructure being cared of by EGI, GISELA will concentrate on its LA component. The tasks, at each level of the e-Infrastructure are: • Institution: Get all Services fully operational in the Resource Centre (RC); • Country: Implement all Grid Operation Centre (GOC) Services; • Continent: Implement all Grid & Network Support Centres (GSC, NSC) Services; • Support a catchall GOC. - Support Virtual Research Communities The support will encompass: • User Support: o Provide access to the EU-LA Infrastructure to VOs represented in GISELA (HEP, Life Sciences, Earth Sciences, etc.); o Publicise and support the GISELA e-Infrastructure and Application Services; o Collaborate with VRCs or SSCs to the development of integrated services (e.g. gateways). • Training & Dissemination activities o Organisation of tutorials for single users and VRCs; o Coordinate dissemination actions, workshops, Conferences; o Produce dissemination material. Grid Services for VRCs will be provided by CLARA on the basis of a business plan using a Life Cycle Product Management (LCPM) approach.

Keywords: e-science - virtual research communities - distributed computing infrastructures - latin america
Multiscale Applications on European e-Infrastructures (MAPPER)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Netherlands,United Kingdom,United Kingdom,Poland,Poland,Germany,Switzerland,Sweden
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-10-01
End date: 2013-09-30
Duration (months): 36.0
Total project cost (EUR): 3272777.0
EU funding (EUR): 2400000.0
Participants: 9
Project status: CLOSED

Today scientists and engineers are commonly faced with the challenge of modelling, predicting and controlling multiscale systems which cross scientific disciplines and where several processes acting at different scales coexist and interact. Such multidisciplinary multiscale models, when simulated in three dimensions, require large scale or even extreme scale computing capabilities. Progress in science and technology is limited by our ability to solve efficiently such problems on available distributed computing infrastructures. The MAPPER project will respond to this critical need by developing computational strategies, software and services for distributed multiscale simulations across disciplines, exploiting existing and evolving European e-Infrastructure. Driven by seven challenging applications from five representative scientific domains (fusion, clinical decision making, systems biology, nano science, engineering), MAPPER will deploy a computational science environment for distributed multiscale computing on and across European e-infrastructures. By taking advantage of existing software and services, as delivered by EU and national projects, MAPPER will result in high quality components for today’s e-Infrastructures. We will advance the state-of-the-art in high performance computing on European e-Infrastructures by enabling distributed execution of multiscale models. We will develop tools, software and services that allow two modes (loosely - and tightly coupled) of multiscale computing, in a user friendly and transparent way. We will integrate our applications into the MAPPER environment, and we will demonstrate their enhanced capabilities by answering one challenging scientific question related to each application. We plan to collaborate with other projects on adaptation of successful MAPPER methodologies, and will work with resource providers to develop policies facilitating the new multiscale computing paradigms.

Keywords: multiscale modelling,distributed computing,grid computing,high performance computing
HYDRALAB IV More than water; dealing with the complex interaction of water with environmental elements, sediment, structures and ice (HYDRALAB IV)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Netherlands,Spain,France,Denmark,Romania,United Kingdom,Germany,France,Portugal,Germany,Norway,United Kingdom,Finland,Italy,United Kingdom,United Kingdom,Spain,Netherlands,Hungary
Call:  (FP7-INFRASTRUCTURES-2010-1, 2010)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 10179401.54
EU funding (EUR): 8499946.86
Participants: 22
Project status: CLOSED

The co-ordinated and integrated approach of HYDRALAB aims at structuring the access to unique and costly hydraulic and ice engineering research infrastructures in the European Research Area. The network of HYDRALAB is unique in the hydraulic research community and has large experience in co-operating since its start in 1997. It began by informing and co-ordinating the activities of the partners in HYDRALAB I and II, and via strong collaboration in HYDRALAB III we will now realize further integration of our research services in Europe in HYDRALAB IV. Over the course of 10 years our network has grown from 8 participants in 1997 to a total of 30 participants from 15 countries today. Research in our infrastructures deals with complex questions regarding the interaction of water with environmental elements, sediment, structures and ice and goes beyond just hydraulic research: hence we have adopted the theme More than water. Questions that we need to answer deal with e.g. the development of adaptive strategies to climate change and sustainable measures against natural hazards, like floods. A fully integrated and balanced ensemble of Networking Activities (5), Joint Research Activities (4) and Transnational Access Activities (10) enhances the operation of our infrastructures and their instrumentation facilities beyond the present state-of-the-art and identifies potential future developments. By means of the common User Selection Procedure optimal access is guaranteed. With our dissemination events we foster a culture of co-operation between the participants and the wider user community. Further objectives of HYDRALAB IV are to improve access to experimental data, by providing researchers with a database on results of experiments, and bring young researchers and first time users from across Europe to the cutting edge of experimental research. As compared to the first proposal for HYDRALAB IV this proposal is improved with the recommendations made by the review panel.

Keywords: experimental hydraulic research,environmental elements,sediment,structures,ice,floods
Scalable Software Services for Life Science (SCALALIFE)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Sweden,Spain,Germany,United Kingdom,Sweden
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 4036387.0
EU funding (EUR): 2450000.0
Participants: 6
Project status: CLOSED

Life Science is developing into one of the largest e- Infrastructure users in Europe, in part due to the ever-growing amount of biological data. Modern drug design typically includes both sequence bioinformatics, in silico virtual screening, and free energy calculations, e.g. of drug binding. This development will accelerate tremendously, and puts high demands on simulation software and support services. e-Infrastructure projects such as PRACE/DEISA have made important advances on hardware and scalability, but have largely been focused on theoretical scalability for large systems, while typical life science applications rather concern small-to-medium size molecules. Here, we propose to address this with by implementing new techniques for efficient small-system parallelization combined with throughput and ensemble computing to enable the life science community to exploit the largest next-generation e-Infrastructures. We will also build a new cross-disciplinary Competence Network for all of life science, to position Europe as the world-leading community for development and maintenance of this software e-Infrastructure. Specifically, we will (1) develop new hierarchical parallelization approaches explicitly based on ensemble and high-throughput computing for new multi-core and streaming/GPU architectures, and establish open software standards for data storage and exchange, (2) implement, document, and maintain such techniques in pilot European open-source codes such as the widely used GROMACS & DALTON, a new application for ensemble simulation (DISCRETE), and large-scale bioinformatics protein annotation, (3) create a Competence Centre for scalable life science software to strengthen Europe as a major software provider and to enable the community to exploit e-Infrastructures to their full extent. This Competence Network will provide training and support infrastructure, and establish a long-term framework for maintenance and optimization of life science codes.

Keywords: life science,molecular simulation,bioinformatics,multi-level parallelism,api,competence centre
Euro-VO International Cooperation Empowerment (EUROVO-ICE)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: France,Germany,Italy,United Kingdom
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 232167.0
EU funding (EUR): 210000.0
Participants: 4
Project status: CLOSED

Astronomy has been a pioneer in the conceptualization and implementation of a science driven ‘virtual infrastructure’, essential to optimize the science return of the large infrastructures of the discipline. The concept of a Virtual Observatory (VObs) is that all the world’s astronomical data should feel like they sit on the astronomer’s desk top, analysable with a user selected workbench of tools and made available through standard interfaces across the whole range of astronomical research topics. VObs is embraced as a world-wide community-based initiative with the potential to transform and restructure the way astronomy research is done. The European Virtual Observatory, Euro-VO, is the European implementation of this idea. The astronomical VObs is undergoing significant evolution with the beginning of its operational phase. Some activities are critical and have to be maintained to assess their evolution and prepare them for being sustained on the long term. The EuroVO-ICE project is a 2-year focussed project which aims at preparing all the necessary measures to continue the pioneering work of Euro-VO and sharing its concepts with other scientific disciplines, (1) by exploring the key points for long term sustainability, including the international, European, and national perspectives, and (2) by assessing how to maximize the impact of the work on the VObs development and of Euro-VO achievements by building partnership with other ‘neighbouring’ disciplines – time for this coordination is now mature thanks to projects recently selected to be supported by EU funding.

Keywords: virtual observatory,european cooperation,international cooperation,astronomy
A worldwide e-Infrastructure for NMR and structural biology (WENMR)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Netherlands,Germany,Italy,Netherlands,United Kingdom,Germany,Taiwan, Province of China,Lithuania
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 2433988.0
EU funding (EUR): 2150000.0
Participants: 9
Project status: CLOSED

Structural biology and life sciences in general, and NMR in particular, have always been associated with advanced computing. The current challenges in the post-genomic era, with their focus on biomolecular interactions, call for virtual research platforms that provide the worldwide research community with both user-friendly tools, platforms for data analysis and exchange, and an underlying e-infrastructure. The WeNMR project will group different research teams into a virtual research community at a worldwide level. It builds on the established eNMR e-Infrastructure tightly integrated into the EGEE and its steadily growing virtual organization currently representing the second largest VO in the life science area. WeNMR will consolidate the operation of the current services and provide an e-Infrastucture platform and structural biology Science Gateway towards EGI for the users of existing infrastructures. It will involve researchers from around the world and will build bridges to other areas of structural biology. Integration with a rapidly growing and highly complementary method, SAXS, is directly included in WeNMR, but links will also be established to related cryo-EM and X-ray crystallography initiatives. WeNMR will serve all relevant INSTRUCT communities in line with the ESFRI roadmap. From an e-infrastructure viewpoint, WeNMR will strengthen the European ties with National Grid Initiatives, the new EGI and PRACE initiatives toward an effective sharing of the offered service. Collaborations will be established with the Asian, South-African, South- and North-American GRID initiatives, in close contact with the existing EC projects, to extend and open the WeNMR Life-Science Gateway at global level. WeNMR will establish and promote best practices in life sciences and offers (virtual) training services to worldwide researchers. It will work with all stakeholders, including an industry panel, to ensure its sustainability.

Keywords: e-science,grid computing,life sciences,structural biology,biomolecular structure,biomolecular interaction