Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Mechanisms of Endometriosis (MOMENDO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Argentina,Germany,Estonia,Sweden,United Kingdom,Chile
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 346500.0
EU funding (EUR): 346500.0
Participants: 9
Project status: CLOSED

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.

Keywords: endometriosis,reproductive medicine,gynecology,pain,microrna,adult stem cells,animal models,uterus,proteoglycans
Technology demonstration of large-scale photo-electrochemical system for solar hydrogen production (PECSYS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Germany,Germany,Sweden
Call: Development of processes for direct production of hydrogen from sunlight (H2020-JTI-FCH-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 2499992.5
EU funding (EUR): 2499992.5
Participants: 7
Project status: CLOSED

The objective of the project PECSYS is the demonstration of a system for the solar driven electrochemical hydrogen generation with an area >10 m². The efficiency of the system will be >6% and it will operate for six month showing a degradation below <10%. Therefore, the consortium will test various established PV materials (thin-film Silicon, crystalline Silicon and CIGS) as well as high potential material combinations (Perovskite/Silicon). It will study and develop innovative device concepts for integrated photoelectrochemical devices that will go far beyond the current state of the art and will allow to reduce Ohmic transport losses in the electrolyte and membranes. The best concepts will be scaled up to prototype size (>100 cm²) and will be subject to extensive stability optimization. Especially, the use of innovative ALD based metal oxide sealing layers will be studied. The devices will have the great advantage compared to decoupled systems that they will have reduced Ohmic transport losses. Another advantage for application in sunny, hot regions will be that these devices have a positive temperature coefficient, because the improvements of the electrochemical processes overcompensate the reduced PV conversion efficiency. With these results, an in-depth socio-techno-economic model will be developed to predict the levelized cost of hydrogen production, which will be below 5€/Kg Hydrogen in locations with high solar irradiation, as preliminary back of the envelope calculations have revealed. Based on these findings, the most promising technologies will be scaled to module size. The final system will consist of several planar modules and will be placed in Jülich. No concentration or solar tracking will be necessary and therefore the investment costs will be low. It will have an active area >10 m² and will produce more than 10 Kg of hydrogen over six month period.

Keywords: hydrogen,photovoltaics,photo electrochemical conversion
BioREAD; a Continuous Barrier Quality Monitoring System for Organs-on-Chip (BioREAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Organs-on-chip are expected to play a crucial role in the pharmaceutical industry for drug development and study of organs and diseases. We propose the development of an electrical detector that enables simple, versatile and continuous quality monitoring of these devices and is essential for commercialization. Combined with recent advances in stem cell technology, Organ-on-Chips can be used to do drug screening on an individual level. Therefore it can serve as instrument for personalized medicine, by determining the effectiveness of selected compounds, as well as possible side-effects to determine safe drug doses on a person-specific level. Moreover, Organs-on-Chip will greatly contribute to a further reduction in the need for animal testing. Besides the pharmaceutical industry, Organs-on-Chip hold great promise for the food and cosmetics industry to test the safety of products. Organ-on-Chip systems need continuous monitoring of the quality of the cell barrier to guarantee reliable outcomes of the drug development tests. State-of-the-art methods, such as fluorescence and commercially available Trans-Endothelial Electrical Resistance (TEER) measurement apparatus are discontinuous, inaccurate and/or harmful for the cells and therefore unsuitable for pharmaceutical applications. Our innovation overcomes these disadvantages. It enables continuous quality monitoring of the barrier function of the organ, which is essential for the commercialization of Organs-on-Chip. The BIOS-Lab on Chip group holds an excellent record in high-quality TEER measurements, demonstrating direct current (DC) TEER-measurements in a gut-on-a-chip in a top-15 of most cited research papers in the journal Lab-on-Chip in 2015 and has ample experience in the development of a blood-brain barrier on chip. This proposal is part of the ERC-project Vascular Engineering on-chip using differentiated Stem Cells (VESCEL).

Keywords: organ on chip,trans endothelial electrical resistance,personalized medicine,impedance spectroscopy,pharmaceutical industry,drug development
Self-Injection-Locked Integrated Analog-to-Digital Converter (SILICON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The Internet-of-Things (IoT) will soon represent the main target application of ICs, involving thousands of autonomous devices forming a large communication network for the purpose of exchanging/processing information about the physical world. From a hardware standpoint, the RF wireless transceivers of IoT devices demand the highest possible energy efficiency and a small area to enable inexpensive large-scale integration. Since analog/RF building blocks must be integrated with the mainstream digital technology, new circuit topologies and techniques must be adopted. The time-mode signaling, recently exploited in all-digital PLLs, data converters (the so called time-mode or VCO-based ADCs), opamps and filters, allows the performance of “analog” circuits to improve with the technology scaling. The proposed research focuses on a novel architecture of time-mode ADC, attempting to mitigate the fundamental limitations of such class of converters (i.e. the highly nonlinear VCO) by exploiting advanced RF techniques, thus giving rise to a hybrid time/frequency-mode operation. Studies have shown that by injection-locking an oscillator to its own delayed resonating waveform (self-injection-locking, SIL), the oscillating frequency can be made reasonably linear versus only two well-controlled parameters (i.e. the amplitude and phase of the self-injected signal). The SIL technique will be exploited to achieve a known, predictable relationship between the oscillating frequency and a certain analog quantity (i.e. the input signal). Accordingly, the proposed research attempts to mathematically overcome, and not to compensate accordingly, the nonlinear characteristic of an oscillator. By adding a simple digital frequency detector, SILICON has potential to devise a new class of data converters, the SIL-ADCs. It will also provide the applicant with cutting edge training from academic & industry leaders in the field which will be implemented using a personalised career development plan.

Keywords: analog to digital converter,oscillator,ring oscillator,lc oscillator,injection locking
High Resolution Extreme Ultraviolet Laser Spectroscopy (XUV-COMB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 1968125.0
EU funding (EUR): 1968125.0
Participants: 1
Project status: CLOSED

Discrepancies between theory and experiments have been fuelling the development of physics from the discrete line spectrum of hydrogen, where classical physics fails, to the Lamb shift, which is unexplained by the Dirac equation. At the precision frontier, comparisons between theory and experiment have been performed almost exclusively with atomic hydrogen. To progress from there, it very good accuracy. The spectroscopic investigation of muonic hydrogen, which was successful recently, was the first step in that direction and has brought up a serious challenge to Quantum Electrodynamics (QED). Even though we could solve this problem in the meantime, there might be others waiting to be discovered when leaving the beaten track of ordinary atomic hydrogen. Besides anti-hydrogen, high resolution laser spectroscopy of singly ionized helium is the next logical item on the list. In addition of representing a hitherto unexplored system, He+ allows for a far better test than atomic hydrogen due to the QED power series expansion of its energy levels in terms of ZWith the nuclear charge Z and the fine structure constant the disputed terms are of the order of (Z)6. Unlike ordinary hydrogen, He+ can be readily stored in an ion trap and sympathetically cooled by co-stored ions with an accessible cooling transition. This approach eliminates essentially all dominating experimental uncertainties that we face with ordinary hydrogen today. The 1S-2S resonance is the sharpest and hence most interesting transition. Its observation requires highly coherent extreme ultraviolet radiation at 60.8 nm which can be generated through high order harmonics from a mode locked laser. The resulting frequency comb is most suitable for a two-photon transition as photons from pairs of modes combine to deliver the excitation energy. Other applications of such new laser source are foreseeable.
DRop-on demand flexible Optoelectronics & Photovoltaics by means of Lead-Free halide perovskITes (DROP-IT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Switzerland,Poland,Poland,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-11-01
End date: 2023-04-30
Duration (months): 42.0
Total project cost (EUR): 3461345.0
EU funding (EUR): 3461344.0
Participants: 8
Project status: SIGNED

DROP-IT proposes combining optoelectronics and photonics in a single flexible drop-on demand inkjet technology platform by means of exploiting the enormous potential of lead-free perovskite (LFP) materials. Specifically, novel crystalline structures beyond conventional ABX3 LFP (double-perovskites and rudorffites) will be computationally screened and chemically synthesized with superior properties as LFPs proposed in the literature. A(Sn-Ge)X3 (A=organic,Cs; X=Cl,Br,I) materials will be considered for initial benchmark devices. The future of DROP-IT technology is envisioned at long-term in the fields of photovoltaics, lighting and printed integrated photonics. This will be possible by developing highly innovative fabrication routes (inkjet printing towards Roll-to-Roll) of LFP pioneering materials (in bulk and nanoscale) by low-cost, high throughput, sustainable, large-scale fabrication techniques on flexible substrates (PET, f.e.) to revolutionize future power, lighting and communication systems. DROP-IT major novelty relies on the innovative use of newly synthesized LFPs in combination with the use of affordable, mask-less, drop on demand inkjet printing onto flexible substrates. The targeted breakthroughs towards the long-term vision of our technology will be based on the following challenges: (1) Theoretical screening of different LFP compound families and chemical synthesis of most suitable ones in the form of nanocrystals and polycrystalline thin films, (2) Formulation of specific and suitable inks of these materials for (3) Inkjet printing of thin films on flexible substrates and (4) Development of stable optoelectronic and photonic devices (solar cells with 12-15% and LEDs with 14-18% efficiencies, amplifiers-lasers with low threshold) as proofs-of-concept for a future technology based on new inorganic LFPs and charge transport layers. DROP-IT is supported by a strong and interdisciplinary consortium with complementary expertise to achieve these objectives.

Keywords: lead free perovskites,ab initio electronic structure,synthesis of nanocrystals,inkjet printing,perovskite thin films,optoelectronics,flexible solar cells,flexible leds,flexible photonics
Ecologically and Economically viable Production and Recycling of Lithium-Ion Batteries (ECO2LIB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Austria,Germany,Germany,Poland,Sweden,France,United Kingdom
Call: Strengthening EU materials technologies for non-automotive battery storage (RIA) (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 7999730.0
EU funding (EUR): 7999730.0
Participants: 11
Project status: SIGNED

After the successful project Sintbat, this project aims to continue the effort with the modified objectives of LC-BAT-2-2019. This new call moves the focus to a new KPI, the cycle related costs per energy: €/kWh/cycle. It very well reflects the real need of the customers if a minimum volumetric energy density is added. An extended LCA, cradle-to-grave will be setup to judge the environmental impact of the different options and to choose the best. To show the both ECO-aspects (ECOlogical and ECOnomical) of our project the acronym ECO²LIB was created. Especially for the deployment of advanced battery systems, time to market is an important factor. This criterion is helpful to select between the different electrochemical systems: - Lithium-Sulphur: is heavily investigated, but up to now doesn’t show a break-through to reach acceptable cycle life - Lithium-Air: For this system, many major problems are known to be solved, like Li metal protection, dendrite growth, cleaned air inlet, oxygen-stability of the catholyte - Zinc-Air: is better, but this system, as all Metal-Air systems, will never lead to a maintenance-free battery - All-Solid-State: has a chance in the polymer version, but rather not in oxidic or sulfidic version - Sodium-Ion: can be potentially interesting for large-scale storage due to cost advantages (replacing Cu with Al), but is still held back due to the lack of a useful and stable anode material and a complex surface chemistry - Organic-based systems: can be potentially interesting for large-scale storage due to potential sustainability impacts, but have problems regarding energy density (especially volumetric), cycling stability, and materials degradation Consequently, the consortium decided to continue the improvement of the well-established Lithium-Ion system with advanced materials, methods and corresponding recycling-concept. So it will be possible to directly exploit the results of ECO²LIB in an IPCEI project, which is under preparation.

Keywords: lithium,battery,energy,storage,silicon,electrode,electrolyte,anode,cathode,operando,characterisation,modelling
World first self-responsive emergency call system (VIEW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

What does it happen when a person collapses unconsciously or behaves conspicuously or luggage or any object is left unattended in an elevator? Either the next passenger will bump into the situation or the people behind surveillance cameras, if existing, may react. As a result, safety is limited, operation costs increased and security risks exist. At VIEW Promotion GmbH we have developed a solution that automatically detects emergencies in the elevator, puts them into context and takes appropriate action. Applications include unconscious persons, abandoned objects, vandalism or violent attacks. VIEW goes beyond industry standards offering automatization and optimization of operation and maintenance and reducing operation costs. VIEW prototype has been tested in real scenario with a 100% success with our image recognition and deep learning algorithm technology. Next steps include product optimization for 100% reliability, price reduction and industrialization. We have been in the industry for years and have already secured clients and great interest from the industry. Our customers are elevator owners, ranging from office buildings, to car parks, public spaces or airports. VIEW solution fits within the current trend of Smart Elevators and targets the Global Elevator Modernization market, with an estimated size to reach €10,562M by 2021, growing at a CAGR of 4.16%. VIEW is exploited through two revenue sources: price per unit and a concurrent O&M service fee. Moreover, the smart screen can be monetized through the sale of the advertising space. We expect a 3 years cumulative revenue of €34.6 million by 2023 and grow our team from 7 to 20 employees.

Keywords: elevator,smart elevator,safety,automation,emergency,inclusive design
A Social Manufacturing Framework for Streamlined Multi-stakeholder Open Innovation Missions in Consumer Goods Sectors (iPRODUCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Italy,Italy,Spain,Greece,Belgium,Greece,France,France,France,Denmark,Luxembourg,United Kingdom,United Kingdom
Call: Open Innovation for collaborative production engineering (IA) (H2020-NMBP-FOF-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 6884420.58
EU funding (EUR): 5799772.09
Participants: 25
Project status: SIGNED

Democratized innovation holds undeniable promise for European producers, but the integration with corporate innovation practices is in its infancy. While the interest is real, it is still neither easy or efficient for producers – especially SMEs to benefit from collaborative production. The iPRODUCE project takes well proven concepts and approaches (from DIY manufacturing, FabLabs, Makerspace), and aims to upscale them through innovative technology solutions and to install them in well-connected multi-stakeholder ecosystems under an umbrella concept of collaborative Manufacturing Demonstration Facilities (cMDF)”. We organize our work under a social-manufacturing platform that enables multi-stakeholder interactions and collaborations to support user-driven open-innovation and co-creation. At the heart of the iPRODUCE platform is an open digital space supported by a set of innovative tools that cover matchmaking, secure interactions, generative product design, process orchestration, agile prototyping, usability evaluations and lifecycle management. We complement these technical tools with a strong social component that aims at easing the notorious hardship of engagement with makers and aim to open up to new maker segments, while we improve on SoA tools for Lead User Innovation identification. The iPRODUCE platform will be deployed in six local ‘ecosystems’ which cover different levels of maturity with collaborative production, diverse objectives and application areas spanning from home furnishing, automotive/mobility, consumer photography, medical ecquipment and more. The platform supports knowledge and resource sharing across cMDFs and all our results will be monitored and evaluated.

Keywords: social manufacturing,user driven innovation,consumer goods sectors,social engagement,innovation platform