Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On-site and On-demand Flexible Packaging System (APS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Agil Packaging System, S.L. (AGILPACK) reinvents the Major Household Appliances Packaging System (refrigerators, washing machines, dishwashers) replacing Expanded Polystyrene (EPS) with alveolar bubble wrap packaging pieces made from a new type of material: multilayer film. AGILPACK has developed the patented APS flexible system with the following characteristics: replaces packaging solutions using EPS with a new concept based on Bubble Multilayer Film; packaging comprises a set of three-dimensional parts formed by airtight bubbles made from film; it is a complete system including parts design software and machinery, installed at the end of client’s line. The Advantages for clients of APS system compared to actual ones are: APS solution has 30% lower cost than conventional EPS packaging; it is a flexible system because alveolar plastic bubble film parts are custom-made, on-site and on demand; it has a much better sustainability and lower carbon footprint; its easy recyclability leads to a circular economy solution; it helps companies comply with the increasingly stringent regulatory laws of cities and EU for EPS use. Wrapping bubble alveolar film parts have been produced and tested, a software for parts design and calculation has been designed, machine modules prototypes have been developed and tested and the system is ready for optimization at industrial pilot level in a client’s plant. The market target is the bulky white line household appliances packaging sector accounting for more than €177 million in EU and €2.3 billion worldwide. APS highly scalable system will allow AGILPACK, by 2024, to be servicing 16 clients’ plants and to reach a total turnover of €50.9 million.

Keywords: packaging,household appliances,protection,film,plastic bubble,multilayer,polyethylene,polyamide,inflate,wrap,laser,welding,airtightness,on demand,on site,production,co2 footprint
CD8+ T cell metabolism in anti-tumor response (Immunometabolomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2020-06-30
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

Although cancer immunotherapy has achieved significant breakthroughs in recent years that has positioned it as the most promising approach to treat cancer, its overall efficacy remains limited in the majority of patients. Nutrition-deprived conditions at tumor microenvironment poses significant metabolic challenges to tumor-infiltrating lymphocytes which may contribute to failure of anti-tumor activity. The main objective of the Immunometabolomics project is to understand metabolism in CD8+ T cells, during active effector T cell development and exhaustion, using approaches that go beyond current research which have been mostly focused on glucose/energy metabolism thus disregarding the relevance of anabolic and redox reactions that are crucial in correct cellular function and proliferation. Open-ended metabolomics and metabolic flux analysis studies, in combination with genetic, nutrition and pharmacological manipulations will be employed to study areas of metabolism that have not been previously extensively studied in CD8+ T cells including 1C metabolism. The characterization of metabolism in CD8+ T cells will be gradually performed in models of higher complexity and physiological and clinical relevance from in vitro, to in vivo in genetically engineered mouse models of lung cancer and finally in lung cancer patients. Through understanding CD8+ T cell metabolism, and its modulation in cancer within tumor microenvironment, we aim to develop a basic science foundation for increasing immunotherapy efficiency in cancer through the use of complementary nutritional and/or metabolism-targeted pharmacological approaches.

Keywords: immunotherapy,cd8 t cells,1c metabolism
Breathing dynamics in health and disease: how consciousness shape respiratory patterns (ConscBreathDynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 168477.04
Participants: 1
Project status: CLOSED

Breathing is perhaps the most vital physiological function, and it is occurring mainly unconsciously. Yet, despite the deceptive simplicity of breathing, it is an intricate behaviour influence by conscious top-down control and vigilance state. How consciousness shape breathing? What are the neural mechanisms underlying conscious control of breathing? Can breathing dynamics indicate on conscious awareness? We aim to address these questions by employing basic and clinical neuroscience approaches in combination with electrophysiology, neuroimaging and advanced computational tools. Disorders of consciousness (DOC) including vegetative state (VS)/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) offer a unique model to investigate the relationship between consciousness and breathing, by providing a rare opportunity for cross-sectional and longitudinal tracking of breathing dynamics during recovery of consciousness. In the proposed research, we first aim to characterize the interaction between breathing and consciousness state. To do this we will record continues respiration during 24-hour from healthy individuals and DOC patients. Next, we intend to elucidate the neural mechanism underlying conscious regulation of breathing, by recording electroencephalogram (EEG) and functional resonance magnetic imaging (fMRI) activity during a multimodal (olfaction, audition and vision) paradigm designed to consciously and unconsciously trigger respiratory change. Last, we plan to investigate whether breathing dynamics can be used as a diagnostic and potentially prognostic tool to detect awareness in DOC patients, by developing an automated respiratory-based classifier differentiating between UWS and MCS patients. The significance of this study is two-fold; addressing fundamental questions in breathing regulation, and utilizing the interplay between basic physiological function and consciousness to better human condition.

Keywords: disorders of consciousness,consciousness,breathing,olfaction,fmri,vegetative state,minimally conscious state
Thermoplastic material allowable generation using a reliability-based virtual modeling platform (TREAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Belgium,Portugal
Call: Material modelling platform for generation of thermoplastic material allowable (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 1249875.0
EU funding (EUR): 1249875.0
Participants: 3
Project status: SIGNED

Thermoplastic modelling platform for the generation of Reliable design Allowables. The project will target the development of a material modelling platform for thermoplastic material. Numerical model of thermoplastic coupons necessary for material certification will be automatically generated in order to provide robust design allowable. Uncertainty Quantification and Management method will also be used to provide numerical error associated to every generated virtual allowable in order to quantify the effect on model input parameter variability.

Keywords: thermoplastic composite materials,material allowables,modeling platform,reliability,uncertainty quantification and management,virtual testing,finite element models,damage tolerance
NATURAL CAPITAL ACCOUNTANCY TO IMPROVE REPORTING AND ENVIRONMENTAL PERFORMANCE (COUNTMITMENT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Important investment decisions are more and more dependent on companies’ environmental performance and the quality of companies’ external environmental reporting. Thus, the biggest companies around the world disclose their sustainability performance to some degree and listed companies worldwide are increasingly aware of their impacts on the environment. There is a clear need of comprehensive tools to quantify the impacts of companies on natural capital and to help companies mitigate or compensate such impacts, so they keep up with the high environmental reporting standards. Existing solutions oriented to measure and reduce natural capital impacts neither provide an integrated measurement of the impact in terms of ecosystem services nor bring support to improve environmental performance. These tools are usually focused in single sectors and work only at narrow spatial scales (e.g. UK, European). In addition, any of them incorporates natural capital net loss and ecosystem degradation measures and its economic, hindering a more sustainable decision-making To bridge the gap between decision making levels around no-net-loss of natural capital, we, Creando Redes, have designed COUNTMITMENT: an online software that enables companies and public authorities to calculate and compensate the natural capital net debt that every industrial activity in any place can incur COUNTMITMENT will have a deep impact in our company, as we estimate that it will yield a turnover of €7.12M, cumulated profits of €2.85M, 10 new direct jobs and a ROI of 2.01 three years after commercialization, reaching the payback during the second year.

Keywords: natural capital accountancy,ecosystem services,corporative environmental performance,environmental disclosure,environmental impact assessment
Translational implications of the discovery of brain-draining lymphatics (BrainDrain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-08-01
End date: 2023-06-30
Duration (months): 71.0
Total project cost (EUR): 2420429.0
EU funding (EUR): 2420429.0
Participants: 1
Project status: SIGNED

In 2010, 800 billion Euros was spent on brain diseases in Europe and the cost is expected to increase due to the aging population. – Here I propose to exploit our new discovery for research to alleviate this disease burden. In work selected by Nature Medicine among the top 10 ”Notable Advances” and by Science as one of the 10 ”Breakthroughs of the year” 2015, we discovered a meningeal lymphatic vascular system that serves brain homeostasis. We want to reassess current concepts about cerebrovascular dynamics, fluid drainage and cellular trafficking in physiological conditions, in Alzheimer’s disease mouse models and in human postmortem tissues. First, we will study the development and properties of meningeal lymphatics and how they are sustained during aging. We then want to analyse the clearance of macromolecules and protein aggregates in Alzheimer’s disease in mice that lack the newly discovered meningeal lymphatic drainage system. We will study if growth factor-mediated expansion of lymphatic vessels alleviates the parenchymal accumulation of neurotoxic amyloid beta and pathogenesis of Alzheimer’s disease and brain damage after traumatic brain injury. We will further analyse the role of lymphangiogenic growth factors and lymphatic vessels in brain solute clearance, immune cell trafficking and in a mouse model of multiple sclerosis. The meningeal lymphatics could be involved in a number of neurodegenerative and neuroinflammatory diseases of considerable human and socioeconomic burden. Several of our previous concepts have already been translated to clinical development and we aim to develop proof-of-principle therapeutic concepts in this project. I feel that we are just now in a unique position to advance frontline European translational biomedical research in this suddenly emerging field, which has received great attention worldwide.

Keywords: vascular biology,lymphatic vasculature
Reverse engineering sensory perception and decision making: bridging physiology, anatomy and behavior (EngineeringPercepts)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1219000.0
Participants: 2
Project status: CLOSED

Understanding how the brain is able to transform sensory input into decisions is one of the major challenges of systems neuroscience. While recording/imaging during sensory-motor tasks identified neural substrates of sensation and action in various cortical areas, the crucial questions of 1) how these correlates are implemented within the underlying neural networks and 2) how their output triggers decisions, will only be answered when the individual functional measurements are integrated into a coherent model of all task-related circuits. The goal of my proposal is to use the rodent vibrissal system for building such a model in the context of how a tactile-mediated percept is encoded by the interplay between biophysical, cellular and network mechanisms. Specifically, rodents decide to cross a gap when detecting its far side with a single facial whisker. This suggests that whisker contact with the platform, if synchronized with an internal motor signal, triggers the decision. My key hypothesis is that in sensory cortex layer 5 thick-tufted (L5tt) neurons receive touch and motor information via specific pathways that target basal and apical tuft dendrites, respectively. When localizing the far side of the gap, the two inputs coincide and result in burst spiking output to (sub)cortical areas, triggering the gap cross. To test this hypothesis, I will determine all sensory/motor-related local and long-range inputs/outputs to/from L5tt neurons, measure whisker-evoked responses of these populations and use the data to constrain network simulations of active whisker touch. Using a multidisciplinary approach, combining in vivo electrophysiology, virus injections, custom imaging/reconstruction tools and Monte Carlo simulations, my reverse engineering strategy will provide unmatched mechanistic insight to perceptual decision making and will function as a show case – generalizable across sensory modalities and species – of how to derive computations that underlie behavior.

Keywords: gap cross behavior,barrel cortex,connectome,monte carlo simulations,coincidence detection
Towards Understanding the Impact of Climate Change on Eurasian Boreal Forests: a Novel Stable Isotope Approach (ISOBOREAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Finland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1814610.0
EU funding (EUR): 1814610.0
Participants: 1
Project status: SIGNED

The vast boreal forests play a critical role in the carbon cycle. As a consequence of increasing temperature and atmospheric CO2, forest growth and subsequently carbon sequestration may be strongly affected. It is thus crucial to understand and predict the consequences of climate change on these ecosystems. Stable isotope analysis of tree rings represents a versatile archive where the effects of environmental changes are recorded. The main goal of the project is to obtain a better understanding of δ13C and δ18O in tree rings that can be used to infer the response of forests to climate change. The goal is achieved by a detailed analysis of the incorporation and fractionation of isotopes in trees using four novel methods: (1) We will measure compound-specific δ13C and δ18O of leaf sugars and (2) combine these with intra-annual δ13C and δ18O analysis of tree rings. The approaches are enabled by methodological developments made by me and ISOBOREAL collaborators (Rinne et al. 2012, Lehmann et al. 2016, Loader et al. in prep.). Our aim is to determine δ13C and δ18O dynamics of individual sugars in response to climatic and physiological factors, and to define how these signals are altered before being stored in tree rings. The improved mechanistic understanding will be applied on tree ring isotope chronologies to infer the response of the studied forests to climate change. (3) The fact that δ18O in tree rings is a mixture of source and leaf water signals is a major problem for its application on climate studies. To solve this we aim to separate the two signals using position-specific δ18O analysis on tree ring cellulose for the first time, which we will achieve by developing novel methods. (4) We will for the first time link the climate signal both in leaf sugars and annual rings with measured ecosystem exchange of greenhouse gases CO2 and H2O using eddy-covariance techniques.

Keywords: stable carbon and oxygen isotopes,tree rings,forest ecosystem,compound specific,carbohydrates,photosynthesis,boreal forest,intra annual,position specific,eddy covariance,plant physiology
Development of the safety case knowledge base about the influence of microbial processes on geological disposal of radioactive wastes (MIND)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Switzerland,Finland,Belgium,Finland,Sweden,Sweden,Czechia,Czechia,United Kingdom,United Kingdom,United Kingdom
Call: Supporting the implementation of the first-of-the-kind geological repositories (NFRP-2014-2015, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 4712985.0
EU funding (EUR): 4160234.5
Participants: 16
Project status: CLOSED

The multidisciplinary project will address key technical issues that must be tackled to support the implementation of planned geological disposal projects for higher-level radioactive wastes across the EU. Our current understanding of the impact of microbial metabolism on the safety of geological repositories remains tenuous, even though microorganisms may have controlling influences on wasteform evolution in situ, multibarrier integrity and ultimately radionuclide migration from the repository. This proposal targets a number of “high urgency” and “high importance” topics identified in the most recent IGD-TP Strategic Research Agenda, focusing specifically on the influence of microbial processes on waste forms and their behavior, and the technical feasibility and long-term performance of repository components. The project will bring together, for the first time, 15 European groups working on the impact of microbial processes on safety cases for geological repositories across the EU, focusing on key questions posed by waste management organisations. The emphasis will be on quantifying specific measureable impacts of microbial activity on safety cases under repository-relevant conditions, thus altering the current view of microbes in repositories and leading to significant refinements of safety case models currently being implemented to evaluate the long-term evolution of radwaste repositories. The integration of society and policy oriented studies in the project will also extend the impact of the project outside the scientific and technical domain, while a study of expert conceptualization, public perception and risk communication concerning microbial influences in geological disposal, will improve awareness of microbial issues on a broader level. The programme will help the EU claim international leadership in the understanding of the impact of microbial processes on geodisposal, and indeed other technological areas pertinent to the exploitation of the subsurface.

Keywords: microorganisms,repository conditions and microbial processes,safety models