Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploring functional inter-individual variations in the intestinal microbiome for personalized nutrition (InterBiome)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

The intestinal tract is inhabited by a large and diverse community of microorganisms, collectively referred to as the microbiota. When stably maintained, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship can perturb homeostasis and drive chronic intestinal inflammation, a cardinal feature of an array of diseases including Inflammatory Bowel Disease. While many factors regulate microbiota composition and function, numerous studies have revealed a central role for diet in modulating this complex community and, consequently, its impacts on host health. My research group has investigated how microbiota is impacted by components of processed foods, particularly emulsifiers and purified fibres. We have reported that these substances have marked modulatory potential on the microbiota in a way that broadly impacts host physiology. However, the extent of such modulations is not uniform but rather subject to high levels of inter-individual and microbiota-dependent variations. These observations have led to the central hypothesis driving the InterBiome proposal, namely that the intestinal microbiota is a central nexus in driving inter-individual variations in the extent to which various dietary factors impact health. We will investigate this hypothesis via a combination of integrated experimental approaches, including patient-based prospective studies, in vitro microbiota modelling and gnotobiotic approaches. Results of these studies will define mechanisms by which the intestinal microbiota drives inter-individual variation in responses to select food additives in a way that promotes or degrades intestinal health. The InterBiome project will open novel avenues of microbiota research, paving the way for microbiota-based personalized medicine and dietary management.

Keywords: chronic inflammation,diet,emulsifier,soluble fibre,microbiota responsiveness,personalized medicine
The Green Revolution in the Funeral World (GREEN_FUNERAL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1260000.0
EU funding (EUR): 1260000.0
Participants: 1
Project status: SIGNED

The Green Revolution in the Funeral World (GREEN_FUNERAL) project, initiated by C.S.C. srl, aims to revolutionize the funeral industry by introducing a sustainable alternative to traditional wooden coffins used in cremation. The project's primary innovation is the development of a funeral coffin made entirely from High-Density Bio-Polyethylene (bioPE), derived from sugarcane, which significantly reduces environmental impact, conserves natural resources, and meets stringent regulatory requirements. The current funeral industry heavily relies on wooden coffins, contributing to deforestation and high CO2 emissions during cremation. The innovative bioPE coffin addresses these issues by providing a renewable, eco-friendly alternative that reduces CO2 emissions by over 200,000 tons annually if adopted Europe-wide. The bioPE material offers equivalent mechanical properties to traditional polyethylene, ensuring impermeability and structural integrity. The coffin’s design is optimises in all its life cycle phases, its characteristics and its flexible production through injection moulding, offer many functional and economic advantages, reducing costs and improving efficiency. Moreover, the project's alignment with European sustainability goals positions it as a pioneering initiative in the transition towards a circular economy. C.S.C. has secured an international patent for this innovation and aims to leverage its expertise in chemistry, engineering, and economics, alongside strategic partnerships with industry leaders like BRASKEM and EuroStampi, to bring this product to market. The project is supported by significant funding from INVITALIA and seeks additional support from the EIC to move from TRL 6 to TRL8. Ultimately, GREEN_FUNERAL aspires to create a global green revolution in the funeral sector, offering a dignified, sustainable choice for end-users, while contributing significantly to environmental conservation and climate change mitigation.

Keywords: funeral service,environmental sustainability,bio polymers
How plant cells set the tempo of rhythmic shoot construction (TEMPO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 3378750.0
EU funding (EUR): 3378750.0
Participants: 1
Project status: SIGNED

Time is central to the development of the body plan of multicellular organisms. One prominent developmental timing mechanism is the rhythmic, iterative addition of tissues and organs. While the tempo of rhythmic construction is often set by developmental clocks, plants use a unique mechanism in the shoot, whereby rhythmic organogenesis emerges from dynamic changes in the distribution of the hormone auxin. High auxin levels trigger organogenesis but, contrary to a long-standing theory, the period of shoot organ production - or plastochron - cannot simply be encoded in periodic auxin oscillations, due to noise in these oscillations. Revealing how the tempo of shoot construction is established thus remains a critical knowledge gap in plant biology. In TEMPO, we hypothesize that cells record and use the history of their auxin exposure, in order to robustly set the timing of organogenesis and the plastochron at the tissue scale despite noisy auxin temporal information. This fundamental change in the way we understand the relationship between auxin and the plastochron stems from preliminary data from my team suggesting histone acetylation as an epigenetic-tracking mechanism, which allows auxin temporal information to be recorded and utilized for transcriptional control. Uncovering how auxin temporal information establishes the tempo of shoot construction requires multiscale, multidisciplinary approaches. We will combine cutting-edge live-imaging, synthetic biology and computational modeling with innovative optogenetics and single-cell genomics to both ascertain and perturb auxin temporal information and histone acetylation at high resolution, while assessing the effect on cellular transcriptional states and the timing of organ production. Beyond testing whether epigenetic tracking of auxin temporal information sets a robust plastochron across scales, we will reengineer the plastochron to demonstrate that the tempo of shoot construction can be predictively manipulated.

Keywords: time in development,rhythmic development,plastochron,shoot construction,auxin,epigenetics,cellular transcriptional states,live imaging,optogenetics,single cell comics,computational modeling
Positive allosteric modulators of the PD-1•PD-L1 interaction as a new mode of therapeutic intervention for autoimmune diseases: preclinical proof of concept in humanized mice (PAMinMICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The immune system's balance in fighting infections or cancer while avoiding autoimmune reactions is regulated by co-inhibitory and co-stimulatory immune checkpoints (ICs). ICs are major drug targets in immunotherapy, with antibodies (Abs) blocking inhibitory ICs to fight cancer, and Abs blocking stimulatory ICs in clinical trials for autoimmune diseases. Surprisingly, but likely fuelled by the worldwide focus on IC inhibitors, the field largely ignored that ICs are genuine transmembrane receptors that transmit signals upon binding of an extracellular ligand. This leaves unexplored modes of therapeutic intervention that we uncover in my granted ERC-2023-ADG by validating allosteric Nanobodies (Nbs) that bind and stabilize ICs, to agonize their activity as first-in-class allosteric modulators, thus tipping the immune homeostasis balance opposite to IC inhibitors for treating autoimmunity. Recently, we discovered the first-ever positive allosteric modulators (PAMs) of an IC and characterized several PAMs of the human PD-1•PD-L1 complex that agonize PD-L1 binding to PD-1 (affinity) and stimulate IC signalling (efficacy) in a spatio-temporal-selective and pathway-selective manner. Building on these exceptional proof of concept data, I’m founding our next integrated drug discovery company focussing on allosteric immunotherapies as a new mode of therapeutic intervention. With PAMinMICE, I will perform pioneering experiments in animal models and test positive allosteric modulation of the PD-1•PD-L1 interaction in double-humanized PD-1•PD-L1 knock-in mice as a new mode of therapeutic intervention for diverse autoimmune diseases: psoriasis, colitis, atopic dermatitis, lupus, rheumatoid arthritis. This study may provide the first preclinical evidence supporting the use of allosteric modulators targeting inhibitory ICs for treating such disorders, with the goals of (i) benefiting patients, (ii) strengthening our IP portfolio, and (iii) positioning us for successful fundraising toward the spin-off.
The hidden heritage of modern logic (HERITAGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2294070.0
EU funding (EUR): 2294070.0
Participants: 1
Project status: SIGNED

The project's aims are the transcription from shorthand and study of the writings of Kurt Gödel, Gerhard Gentzen, and Paul Bernays on the main problem of the foundations of mathematics, namely the consistency of analysis. These rich sources have remained inaccessible because of their archaic shorthand. Previous work by the PI on Gödel's and Gentzen's shorthand notes has led to stunning discoveries published in many articles and eight books, but it has left the said main problem untouched. The most important uncharted source in Gödel are his 16 "Arbeitshefte," each running up to a hundred pages, and developing topics such as intuitionistic analysis and computable functionals. With Gentzen, the main sources, in another shorthand, are his two long series of notes, the "WA" (Consistency of analysis) and the "BTIZ" (Proof theory of intuitionistic arithmetic). With Bernays, the main sources are his detailed notes for two lecture courses on logic in Göttingen, in 1927 and 1929-30 that surpass by a wide margin anything known before about the birth of today's logic. The first phase of transcription and translation into English of the project aims at finishing volumes that contain all these source materials. After the first phase, a second, interpretive phase of study will be carried through. This is done in collaboration with six leading experts, chosen from different domains so that their expertise as a whole encompasses the topics and results uncovered by the first phase of the project. The project as a whole points at a new approach to the historical study of the development of science and philosophy: It is estimated that there exist thousands of exact recordings of lecture courses in shorthand by students, what are called "Mitschriften." The study of these vast sources will open up a new, third type of sources in the history of science, next to (a) publications and author manuscripts and (b) correspondence: How were the new theories presented to students?

Keywords: development of logic,g del,gentzen,bernays
Cyber SECurity Risk Assessment in virtualized AIRSPACE scenarios and stakeholders’ awareness of building resilient ATM (SEC-AIRSPACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Norway,Germany,Italy,Sweden,Spain
Call: Fundamental Science and Outreach for Virtualisation and Cyber-secure Data Sharing (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 999765.0
EU funding (EUR): 999764.0
Participants: 9
Project status: SIGNED

The SEC-AIRSPACE project aims to enable a more resilient ATM, by focusing on reducing the risks of virtualization and increased data-sharing between all components of the ATM infrastructure and the relevant stakeholders. The project will enhance the state-of-the-art security risk assessment methodology(ies) currently adopted in ATM with prominent cyber security components. Further, the project will investigate the potential of applying the concept of People Analytics (PA) to increase cyber security awareness in ATM organizations. The project results will be validated and demonstrated through two realistic use cases, involving relevant stakeholders.
Hyperfine and Antiferromagnetic Resonances Coupling with Optical Transitions in Rare Earth Crystals for quantum information (Harcotrec)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

The rapid progress in the development of quantum computers is accompanied by the demand for devices enable to connect them into a quantum network. These devices are transducers that coherently convert microwave radiation into infrared light and vice versa at the single-photon level. The aim of the project is thus to investigate an innovative transducer scheme based on fully concentrated rare earth crystals with efficiency, bandwidth and suppression of the added noise higher than the current transducers. By exploiting the large non-linear properties of these crystals in the proximity of their sharp electronic and spin transitions, the microwave field will be mixed with an optical laser field to generate a new optical field that will carry the quantum information previously encoded into the microwave field. To achieve this goal, carefully selected crystals will be grown and their optical, hyperfine and antiferromagnetic resonances analyzed at mK cryogenic temperatures. Ultra-narrow tunable lasers and microwave generators coupled with a radiofrequency cavity will provide the optical and microwave fields and the frequency mixing process will be characterized via heterodyne technique. The rare earth crystals performance will be finally assessed towards implementing microwave to optical transduction in the quantum regime.

Keywords: quantum transduction,rare earth spectroscopy,antiferromagnetic crystals,quantum information,
Dynamics of p53 mutant reactivation and the anti-carcinogenic action of engineered resveratrol analogues (p53-REACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

The project proposal aims to engineer a bacterial host to produce variants of secondary metabolite resveratrol and address the interrelationship between dynamics, structure and function of a system of high medical interest, the tumor suppressor protein p53. The study considers to elucidate the mode of action of these molecules against the p53 mutants and work on new concepts for cancer therapy. Inside the cell, the folding of a protein is a fast and robust process. Sometimes, however, sudden changes in the balance between different existing forces result in incorrect folding of the peptide chain, which ends up generating amyloid aggregates within the cell that lead to the gain of toxic function, since these aggregates can conduct to death of the cell in question. Most amyloidogenic pathologies are neurodegenerative, however the aggregation also plays an important role in cancer. The project provides a broad framework for the study of the resveratrol derivatives acting as p53 aggregation inhibitors by using cutting-edge tools of computational resources, metabolic engineering and structural biology. But could, in principal, be applied to exploit the chemical diversity of other biocompounds similarly intending to act as less cytotoxic agents in a more effective antineoplastic therapy, which represents one of the major existing scientific gaps. It is a proposal on a very important topic that will be studied from a unique perspective.

Keywords: molecular interactions bioinformatics p53 reactivation,resveratrol
Communication in Ancient Anatolia (CAncAn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1598515.0
EU funding (EUR): 1598515.0
Participants: 1
Project status: SIGNED

The project addresses the question of messages, modes and participants in the communication of three Anatolian cultures, Lydians, Luwians and Phrygians, ca. 1200–546 BCE. Living in adjacent territories, they were verifiably in contact with one another. They are normally studied in isolation by different academic subjects, leading to missed intercultural references and interconnections, and preventing the reconstruction of a comprehensive picture. The three cultures, their interesting and diverse text sources, their relationships with one another and their (dis)unity as cultural entities are currently underresearched, and only parts of their text corpora are available in modern editions. The project will be the first to study both internal and external sources from other Ancient Near Eastern and Classical texts together, using a combined semiotic and narratological approach examining text structure, processes of meaning-making, communication and transmission. Texts and their material supports not only generate and exchange meaning, they also preserve information on communication processes in the context of specific realms. Reading these texts with a focus on narrative and discourse will allow a new insight into formative parameters of ancient societies, especially values, cognitive patterns, and the needs and motifs of the participants. This marks a huge shift from traditional, event-based readings towards an analysis of belief and behaviour. The project will be ground-breaking in its application and adaption of concepts from semiotics and narratology, which were developed for the study of the modern world and have never before been applied to the study of these ancient texts. The project will draw a new picture of cultural clusters and their parameters, and provide new data for understanding ancient and modern identities and the potential of cultural differences. Its novel insight into communication can be extended to other Ancient World studies.