Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
RNA Fusion-Inducing Antisense Oligonucleotides as a Treatment for Wiedemann-Steiner Syndrome (FusionASO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

There is an immense interest in RNA therapeutics for a wide variety of health conditions. Neurodevelopmental disorders (NDDs), which mostly have no available treatments or cures, affect millions of children and adults across Europe, and are estimated to account for as much as 1-3% of the total EU healthcare expenditure. Wiedemann-Steiner Syndrome (WSS) is an NDD that currently has no available treatment and is not amenable to traditional gene therapy approaches. Antisense oligonucleotides (ASOs) are a clinically proven way to modulate gene expression, in particularly in the central nervous system. ASOs are almost exclusively used for reduction of gene expression or altering RNA splicing, but these are relevant only in a subset of conditions. Many neurological diseases are caused by haploinsufficiency, in which the patient has one wild-type copy of the gene, but it is not sufficient for normal cellular function. ASO-based approaches for up-regulating haploinsufficient gene expression are sought in many cases, but existing methods, such as those focused on blocking microRNA target sites are often of limited efficacy. In our ERC project, we made an intriguing observation that blocking specific regulatory motifs in the last exon of the CHASERR long noncoding RNAs leads to up-regulation of the downstream CHD2 gene through the formation of a fusion transcript between the two genes. We found that this approach can be translated for the up-regulation of CHD2 in vivo and alleviate disease-relevant phenotypes. In this PoC, we aim to extend this novel concept to WSS and explore and demonstrate the technical viability and commercial potential of targeting the ATP5MG pre-mRNA with specific ASOs to induce fusion formation with KMT2A (MLL1), thereby developing a potential new treatment for WSS. This project will not only advance the scientific understanding and therapeutic potential of this technology but also assess its market readiness and commercial feasibility.
EIT Culture & Creativity (EIT CCSI SUGA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Coordination and support actions
Countries involved: Germany,Spain,Finland,Austria,Italy,Netherlands,Slovakia,Bulgaria,Sweden,Greece,France,Poland,Belgium,Ireland
Call: Horizon-EIT (HORIZON-EIT-2022-KIC-STARTUP, 2022)
Start date: 2022-09-01
End date: 2023-12-31
Duration (months): 16.0
Total project cost (EUR): 5995362.13
EU funding (EUR): 5995362.13
Participants: 31
Project status: CLOSED

This Start-up plan is about creating the EIT Culture & Creativity. Starting by building its legal and operational readiness, and leading on to the design of long-term strategies for partnership growth and ecosystem engagement. All activities carried out during the start-up phase are aimed at enabling this EIT Innovation Community to unlock the latent value of its stakeholders. The focus will be on: Creating the new legal entities, good governance structures, and internal initiatives that foster long-term financial sustainability plans while maintaining the public service mission. Endowing the KIC with appropriate management and operational teams, with attributes and roles that can grow with the KIC; and ensuring the best candidates are recruited to the roles to assume all necessary functions, including supervisory ones. Developing the KIC’s programmatic structures based upon knowledge generated and contributed by the partners, and in alignment with the Strategic Agenda 23-27, and launch the first Call for Proposals for BP 24-25. To raise awareness of the EIT Culture & Creativity, and to develop specific measures to engage and nurture a vibrant community of innovators, from all corners of Europe, and especially from RIS countries. The SUGA is built on 30 partners, and one affiliated entity. The rest of the founding organisations will contribute pro-bono to many of the activities by volunteering staff to the participatory work groups. All these contributions are fundamental to achieving legal and operational readiness, and to building a shared vision for EIT Culture & Creativity.

Keywords: creative,cultural,innovation,ecosystems,incubation,acceleration,civil society,social innovation
Universal, open-source and cybersecure Digital Twin to provide investors in onshore wind farms valuable insights about current operations and future investments. (TWINVEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Belgium,Norway,Greece,Finland,Italy,Austria,Portugal,Türkiye,United Kingdom
Call: Digital twin for forecasting of power production to wind energy demand (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-07-01
End date: 2027-12-31
Duration (months): 42.0
Total project cost (EUR): 6896682.8
EU funding (EUR): 5370902.51
Participants: 15
Project status: SIGNED

TWINVEST intends to create the foundations of a universal, open-source and cybersecure Digital Twin to provide investors in onshore wind farms valuable insights about current operations and future investments. Guide investment decisions in wind energy is a complex as it involves various factors to monitor or assess such as energy production, maintenance, investment framework and characteristics of the wind farm. In order to tackle those different factors, a team of 14 partners have united to create a Digital Twin that seamlessly integrates and considers all these factors. This Digital Twin will have different platforms: i) Framework investment conditions platform focuses on energy storage, energy demand and pricing dynamics, regulatory mechanisms, and the essential grid requisites for ancillary services; ii) Component to Farm platform, focused on different components used for the turbines nominal energy production CAPEX estimation of the investment; iii)Environment and Earth platform’s objective is to assess the impact of weather and wind dynamics, culminating in the provision of real-time energy production projections; and iv) Maintenance and risks platform aiming to optimize OPEX by leveraging predictive methodologies to anticipate potential system failures. The project duration will be 42 months and it will be structured in 3 stages: Stage 1: Platform and model development where the research partners will develop, train and explore different AI models that allows the investor to forecast and monitor essential factors in a wind farm Stage 2 (M6-M42): Digital Twin Integration, where the different mentioned platforms will be integrated ensuring the interoperability among all models; and Stage 3 (M25-M42): Individual Platforms and Digital Twin validation, where the TWINVEST Digital Twin will be validated with real wind energy farms from the industry and will be used to conduct feasibility studies on investment plans coming from industry to show its capabilities.

Keywords: wind digital twin maintenance grid storage demand forecasting price components turbine investment renewables energy
Researcher night: bringing researchers into the light (Researcher night)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-03-06
End date: 2026-03-05
Duration (months): 24.0
Total project cost (EUR): 410180.36
EU funding (EUR): 299977.5
Participants: 3
Project status: SIGNED

With this project we want to bring the figure of the researcher and his work closer to the entire society. For this reason, we organize events in diferent areas of the country, we carry out actions in educational centers and we will organize activities in rural areas, disadvantaged neighborhoods, activities for people with special needs and specific activities of interest for elderly people. We want to include all areas and audiences of society. To do this, we present this project between 2 coordinators and an associated entity that complement each other. We include an entity with great experience in this project and actions to disseminate and bring science closer to society in general and an entity with a national dimension, which covers the field of culture, research and education throughout the country. All this is complemented by the participation of an associate, the Spanish association against cancer; that combines research and dissemination at the national level.

Keywords: diversity inclusion european dimension transfer of results scientific vocations
Sustainable packaging solutions for food and cosmetics based on aquatic biomass and side-streams (AQUAPACK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Greece,Portugal,Italy,Croatia,United Kingdom,Cyprus,Netherlands,Spain,France
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-07-01
End date: 2029-06-30
Duration (months): 48.0
Total project cost (EUR): 1423371.43
EU funding (EUR): 1283400.0
Participants: 15
Project status: SIGNED

The overall objective of the AQUAPACK project is the development and evaluation of the effect of novel biodegradable packaging systems on the quality and safety of perishable food and cosmetics in the supply chain of the EU region and worldwide, through the introduction of economically and environmentally sustainable packaging materials based on marine biomass (micro and macro-algae, fish processing side streams and by-catch). AQUAPACK faces the challenge of reducing plastic pollution through transnationally designed innovations for development of novel biodegradable packaging systems. Well-designed secondments between academic and industrial partners with complimentary capacities, will deliver the project objectives: (i) to introduce economically and environmentally sustainable, low carbon packaging materials based on aquatic biomass and side-streams, that can appropriately preserve the quality and safety of food and cosmetics products, from production all the way to consumption. (ii) design and test at least 2 biodegradable packaging materials appropriate for fish fillets and cosmetics, by developing: (i) biodegradable, active films appropriate for food and cosmetics by utilizing aquatic biomass, (ii) biodegradable films appropriate for secondary packaging of cosmetics. (b) An innovative direct freshness monitoring system (biosensor) applicable across the supply chain of perishable products. (iii) to improve the sustainability of the food and cosmetics sectors by preserving their quality, extending their shelf life and thus reducing waste. (iv) reduce waste of packaging materials by applying non-plastic, biodegradable packaging solutions for food and cosmeceutical products. (v) assess the sustainability and safety of the new packaging solutions in comparison to commonly used packaging for food and cosmetics. (vi) to provide cross-cutting interdisciplinary knowledge exchange, technology transfer and training to improve employability and career prospects.

Keywords: biodegradable packaging active packaging smart packaging biopolymers bioactive compounds extracts microalgae macroalgae fish processing side streams waste valorization
Digital design and robotic fabrication of biofoams for adaptive mono-material architecture (ARCHIBIOFOAM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Finland,Italy,Germany
Call: EIC Pathfinder Challenge: AEC digitalisation for a new triad of design, fabrication, and materials (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 3422982.5
EU funding (EUR): 3422982.5
Participants: 4
Project status: SIGNED

The overall objective of the ARCHIBIOFOAM project is to create mono-material yet multifunctional systems for architecture through the additive fabrication of shape-changing load-bearing biofoams. Our approach integrates biobased materials science, computational metamaterial design, and robotic additive manufacturing to enable the structuring of the novel biofoam material at multiple hierarchical scales. The objectives are (i) to create 3D-printable biofoams with programmable properties at the microscale, (ii) to develop a computational design algorithm for optimal biofoam-based metamaterial structures and (iii) to develop the fabrication processes for producing components with tailored stiffness and autonomously actuating parts at an architectural scale. The objectives will be achieved by manipulating the microstructure of bubble films in the biofoam to directionally expand or contract to external stimuli such as temperature and humidity. The mesoscale geometry of the biofoam will be automatically generated by a multi-objective optimization algorithm to achieve the targeted shape changes. The computationally designed biofoam structures will have both loadbearing and shape-changing capabilities constructed at the meter scale by our new robotic additive fabrication processes. Our biobased mono-material systems will meet multiple performance criteria and eliminate the need for multi-material layered construction by leveraging the properties and geometry of materials at multiple hierarchical scales. We will engage with the AEC sector to facilitate the uptake of our new digital design and fabrication process to enable a reduction of embodied CO2 emissions through the use of alternative materials. This novel computational fabrication approach will align with global efforts to address the current climate challenge, aiming to enable biobased materials that can outperform high embodied energy construction materials while being recyclable and compostable at their end-of-life.

Keywords: digital design,fabrication,biofoams,metamaterials,adaptive architecture
Semi-Centralized Platforms for Steering Online Multi-Learner Environments (PLA-STEER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1316544.0
EU funding (EUR): 1316544.0
Participants: 1
Project status: SIGNED

In scenarios like online advertising markets and financial exchanges, autonomous, self-interested learning agents engage in strategic interactions via a shared platform. Platforms typically opt for a passive role, providing the shared infrastructure necessary for the operation of the multi-learner environment, while keeping learning procedures decentralized. Fully centralized systems can potentially yield superior outcomes by optimizing shared objectives like social welfare, but they are seldom chosen. The goal of this project is to bridge the gap between these two extremes by establishing the theoretical foundations of semi-centralized platforms (SCP). SCPs aim to combine the best attributes of both centralized and decentralized systems, enabling next-generation platforms to operate efficiently at scale with the flexibility of decentralized learning, while also being able to steer learning agents towards desirable objectives. Using tools from online learning and computational game theory, we will develop innovative techniques to determine when and how platforms should actively influence the actions of learning agents. In this endeavor, we will i) develop a better understanding of the learning dynamics of traditional platforms; ii) explore methods to overcome well-known computational challenges that hinder the convergence of multi-learner systems towards shared objectives; and iii) extend fundamental game-theoretic models to realistic settings. This research will pave the way for practical applications on real-world platforms and address pressing concerns related to fairness and accountability in their outcomes, which are expected to become even more significant as machine-learning algorithms gain wider adoption.

Keywords: online learning,learning dynamics,bilateral trade
Optimised DYnamics of high voltage powertrains: developing Sustainable Systems for Electric Vehicles (ODYSSEV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Spain,Germany,United Kingdom,Netherlands,Greece,Switzerland,Sweden,France
Call: Integration and testing of next generation post-800V electric powertrains (2ZERO Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2026-01-01
End date: 2029-06-30
Duration (months): 42.0
Total project cost (EUR): 5999810.0
EU funding (EUR): 5999810.0
Participants: 14
Project status: SIGNED

As the demand for fully EVs rises due to sustainability and decarbonization efforts, consumers' concerns such as longer driving ranges and quicker charging times must be addressed. To this end, ODYSSEV is developing advanced automotive power converters and optimizing powertrain elements to utilize HV levels and novel electronic topologies. The project centers on a hybrid inverter concept that leverages the benefits of both RC-IGBTs and SiC MOSFETs under various load conditions, aiming for the best techno-economic performance. Innovations include optimizing the HV motor's geometry and topology to avoid issues like partial discharge and current harmonics, and designing a reconfigurable battery pack. This battery pack can be charged at lower voltages (400-800V) and provide higher voltages (1200-1600V) during traction mode. The preliminary design targets a 1200V and 100 kW powertrain, with various scenarios to be analyzed for potential HVs. Additionally, ODYSSEV will innovate in areas such as the on-board charger, system packaging, and overall powertrain control. The project aims to demonstrate this HV powertrain integrated in a real vehicle in real driving tests, thereby providing evidence of reduced costs, losses, and weight for EV manufacturers. The ODYSSEV project involves a consortium of 14 partners from 8 countries, including research institutions, universities, and industrial stakeholders. This group will employ a Safe and SSbD, utilizing virtual environments with PHIL capabilities for cost-effective and efficient prototyping. The consortium has access to necessary facilities and networks for manufacturing, prototyping, and testing innovative automotive solutions. The expected impact includes a 30% reduction in energy losses and a 20% increase in driving range, with significant cost reductions (up to 20% for power electronic modules) and enhanced fast-charging capabilities (20-80% charge in 10 minutes with 350kW chargers).

Keywords: adjustable hybrid cross switch inverter,post 800v electric powertrain,on board charger,reconfigurable battery architecture,hv motor,sustainable and safe by design,power hardware in the loop
Flexible system extending automated border surveillance by increased situational awareness adaptable to uncertain times with unforseen events (BorderForce)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Border Management
Action type: Innovation actions
Countries involved: Austria,Cyprus,Luxembourg,Spain,Greece,Germany,Finland,Albania,Bulgaria,Moldova, Republic of,Slovakia,Lithuania,Romania
Call: Capabilities for border surveillance and situational awareness (HORIZON-CL3-2023-BM-01, 2023)
Start date: 2024-11-01
End date: 2027-04-30
Duration (months): 30.0
Total project cost (EUR): 4586015.59
EU funding (EUR): 3992775.16
Participants: 18
Project status: SIGNED

The EU has experienced a surge in fixed border surveillance solutions, including physical barriers, covering 13% of external land borders. The BorderForce project responds to evolving threats by enhancing real-time surveillance capabilities. It introduces a dynamic system, featuring self-sufficient, transportable Command and Control (C2) Stations with configurable and extendable capabilities. These stations incorporate versatile surveillance towers with anti-drone features, integrating data from autonomous monitoring sensors and UAV systems. Dedicated satellite resources, including CubeSat, strategically positioned at high-risk spots, ensure frequent revisits to critical areas. To enable early threat assessment, BorderForce leverages Open-Source Intelligence (OSINT), processing online data for border security threats. The project emphasizes ethical, legal, and social aspects, safeguarding fundamental rights in border surveillance capability development. BorderForce collaborates with EU and candidate country border authorities, customs, and Common Security and Defense Policy (CSDP) entities. It defines scenarios, gathers architecture feedback, and validates end user feedback. The project emphasizes data exchange, novel user interfaces (e.g., XR), and immersive training for collaborative threat assessment, promoting safety and security while upholding fundamental rights. This solution enhances resource sustainability by improving the coordination and deployment of reusable security measures. The BorderForce solution will be validated in 2 field trials to become TRL7. It ensures seamless operations in monitoring the flow of goods, people, and information. Addressing challenges like migration, smuggling, and geopolitical tensions, BorderForce contributes to regional stability, particularly in crises. Overall, it combines technological innovation and international collaboration to bolster border security, prioritizing fundamental rights and ethical considerations.

Keywords: customs