Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nutrient Management and Nutrient Recovery Thematic Network (NUTRIMAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Spain,Belgium,Belgium,Hungary,Belgium,Poland,Hungary,France,France,France,France,Netherlands,Netherlands
Call: Thematic networks compiling knowledge ready for practice (H2020-RUR-2018-1, 2018)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 1999927.5
EU funding (EUR): 1999927.5
Participants: 18
Project status: CLOSED

Agriculture and food industry having a high dependence on resources in their production and striving for long-term sustainability. In this context there is an urgent need to optimise resource use and smooth the transition to a knowledgedriven agriculture. The NUTRIMAN is a Nitrogen and Phosphorus thematic network compiling knowledge “ready for practice” for such recovered product applications, practices and technologies, interconnecting applied science and industrial practice, for the user interest and benefits of the agricultural practitioners. There is an urgent need to spread knowledge and network information towards agricultural practitioners about the insufficiently exploited N/P recovery innovative research results (technologies, products, practices). The project objective is to improve the exploitation of the N/P nutrient management/recovery potential for the ready for practice cases not sufficiently known by practitioners. Our action will open new opportunities for farmers to develop connections between applied researches with practical usefulness results and farming practice in the priority area of nutrient management and nutrient recovery. Uses a bottom-up approach to identify incentives and bottlenecks for adoption and to prioritise between technologies/products and will ensure larger willingness to adopt innovations and improve multiplicator effects. Large scale take up of the recovered N/P innovative fertilisers targeted, produced from un-exploited resources of organic or secondary raw materials in line with the circular economy model, and economical/environmental efficiently used by farmers. Effective dissemination and exploitation promoted by multilingual web platform, other communications and best practice field demonstrations for farmers. This action is contributing to the successful deployment of the vast reservoir of existing scientific/practical knowledge on the N/P recovery theme, including multi lingual abstracts in EIP-AGRI format.

Keywords: networking,nitrogen,phosphorus,nutrient recovery,innovative fertilisers,biochar,struvite,best,practices,knowledge transfer,agri practices,eip agri,agri practitioner ash,compost,digestate
Multiphoton Voltage Imaging (MULTIVIsion)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1499655.0
EU funding (EUR): 1499655.0
Participants: 1
Project status: SIGNED

Understanding the brain is one of the great scientific challenges of our time. This pursuit fundamentally depends on advances in physical sciences and engineering to provide novel tools and methods to perturb, record and interpret brain activity. Information in the brain is encoded in changes in the voltage across the membrane of brain cells. Voltage imaging with genetically encoded voltage indicators (GEVIs) is a revolutionary method that allows faithful recording of the fast electrical dynamics of many genetically targeted cells in parallel. This provides an unprecedented means to record how patterns of change in this membrane voltage, called action potentials, manifest in subcellular compartments, cells, and networks across the brain, which is the only way to arrive at a fundamental understanding of brain functions like learning and memory, and of neurogenerative diseases. For this promise to be fulfilled, we need voltage imaging deep in the living brain of awake and behaving organisms. To achieve this, I will evolve a GEVI optimized for three-photon (3P) imaging, by screening mutant libraries of GEVIs directly for brightness and photostability under 3P-excitation, voltage sensitivity, and membrane trafficking in neurons. I will optimize the photocycle dynamics of GEVIs with temporally structured light, using a NOPA with tunable repetition rate, pockels cell and multiple optical delay lines, to create optimal 3P excitation protocols. Crucially, this optimization will not depend on spectral phase and is therefore compatible with high speed multiphoton imaging, aberration correction, and deep tissue imaging. Finally, I will investigate memory formation in a proof-of-principle experiment. I will use a custom microscope I developed, for 3P voltage imaging of cells in the cerebellum of mice trained in an eyeblink task. Memory formation in this paradigm is hypothesized to look like subtle changes in the exact shape and timing of action potentials, which I will resolve.

Keywords: protein evolution,multiphoton imaging,light matter interaction,deep tissue imaging
Affective work-related daily events, and changing characteristics of the work context: New challenges for management practices to deliver employees’ well-being and workplace performance (EVENTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Affective experiences resulting from specific work-events are present everywhere in daily work. Its importance has been highlighted for both managers and researchers. However, research into the understanding of how contextual factors, such as job characteristics or management practices, influence work-related daily events, which in turn, affect individual performance and well-being has been narrow, incomplete, and problematic. This project aims to explore the relationships between new characteristics of the work context, daily events at work, performance management practices and other outcomes in a longitudinal approach. Accordingly, this project focuses on: (a) the work characteristics associated to workrelated daily events, over time; (b) the relationship between daily events and performance and health, over time; d) the influence of high performance management practices on those relationships. By addressing the relationship between contextual factors with work-related daily events at work over time, this project makes important contributions to theory development within the field. The findings may help managers to understand how daily events influences employees’ performance and well-being. Moreover, it will help to produce practical instruments and to develop strategies to deal with daily events that may improve productivity and quality of life at work.

Keywords: work related affective events,performance management practices,job design,changes in the nature of,work,job characteristics,performance,well being,health,longitudinal methods
Oscillatory neural and autonomic correlates of social attunedness during early life: new mechanistic insights into how we learn to learn from one another (ONACSA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1499274.0
EU funding (EUR): 1499274.0
Participants: 1
Project status: SIGNED

We are a social species. Most infants, and young children, spend the majority of their early waking lives in the company of others. But, for practical reasons, almost everything that we know about how the brain subserves early attention and learning comes from studies that examined brain function in one individual at a time. This means that we understand lots about how children attend and learn from information presented while they are alone, viewing a computer screen - but little about how attention is shared between people during social interaction. ONASCA will develop new techniques to look, for the first time, at how two brains dynamically interact with one another during early learning exchanges. The project will determine how children’s active, participatory bids during learning lead to reactive changes in both members of the dyad – and how these changes, in turn, influence both partners’ subsequent attention, and learning. It will also determine how, and why, some infants, and some parents, show greater sensitivity during social exchanges than others. And, using targeted interventions, it will investigate whether social sensitivity can be improved. The question of how two brains dynamically influence one another during learning exchanges has been described as the ‘dark matter’ of social neuroscience. Yet nobody has looked at these questions before from the perspective of early learning. Our results may help us to move beyond viewing children primarily as passive recipients of information during learning exchanges, to a perspective that better appreciates children’s role as active participants in learning. Our findings may also have practical implications for educationalists, and clinicians.
FLOW Control Actuators at Aircraft scale manufacturing by SLM with high aerodynamic performance for using in Harsh environment (FLOWCAASH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: 3D printing and harsh environment testing of flow control actuators at aircraft scale (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-04-01
End date: 2020-12-31
Duration (months): 33.0
Total project cost (EUR): 549061.25
EU funding (EUR): 549061.25
Participants: 2
Project status: CLOSED

The main goal of FLOWCAASH project is to design and manufacture reliable and safe flow control actuators at aircraft scale by Selective Laser Melting (SLM) able to withstand the high temperatures (up to 260 °C) and pressures (5 bar) during flight test with aerodynamic performance and high resistance to harsh environments. FLOWCAASH project is focused on the development of innovative designs of Active Flow Control (AFC) actuators to be manufactured by powder bed based additive manufacturing (AM) using Ti6Al4V alloy. Selective Laser Melting (SLM), that utilizes a laser as a thermal energy source to melt the powder has been chosen as the preferred AM technology. The innovative designs of these AFC actuators will allow to be installed in restricted space in the next generation aircrafts with UHBR (Ultra High Bypass Ratio) engines. Two different actuators will be considered, Pulsed Jet Actuator (PJA) and Steady Blowing Actuator (SBA). These actuators will have the potential to reduce aerodynamic flow separation and to increase lift coefficient. This will be obtained by bionic design which allows complex geometries and improve structural strength while reducing the weight. In order to assure process reliability of large Ti parts, distortion prediction numerical simulations will be accomplished. As-built part will be post-processed by means of heat and surface treatments in order to ensure dimensional stability and adequate surface quality for aerodynamic performance. Afterwards the actuators will be validated by aerodynamic and harsh environment tests including rain, icing, sand and dust, vibrations and anti-icing fluid. The FLOWCAASH project will be developed by a well-balanced consortium that brings together 2 partners: the research center LORTEK and the aerospace test laboratory CTA.

Keywords: topology optimization,bionic design,active flow control actuators,distortion prediction,fem simulation,ti6al4v,aerodynamic and harsh environment testing
Microbioreactor platforms as in vivo-like systems to probe the role of Neuroblastoma-derived Exosomes in cancer dissemination (MICRONEX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2023-11-30
Duration (months): 72.0
Total project cost (EUR): 1446250.0
EU funding (EUR): 1446250.0
Participants: 1
Project status: SIGNED

Engineers can actively contribute to fields thought to be out of their “comfort zones”. We can be leaders of discoveries that translate into advances in the understanding of disease and improving human health. Engineers might use different language and tools than Life Sciences Scientists but we find a common ground, as the laws of Thermodynamics, Physics, and Mathematics also apply to biological phenomena. The development of microbioreactors (μBRs) reconstructing biologically sound niches can revolutionize medical research. In our bodies cells reside in a complex milieu, the microenvironment (μEnv), regulating their fate and function. Most of this complexity is lacking in standard laboratory models, leading to readouts poorly predicting the in vivo situation. This is particularly felt in cancer research, as tumors are extremely heterogeneous and capable of conditioning both the local μEnv and distant organs. Neuroblastoma (NB) is the most common and difficult to cure pediatric malignant solid tumor. Secreted exosomes are means by which NBs reshape their μEnv and induce local and long-range changes in cells, regulating progression and prognosis. But the mechanisms involved are yet not completely understood. A major limitation is the difficulty to model in vitro the local in vivo dynamic μEnv. We hypothesize that μBRs exploiting classical engineering principles will solve the limitations of existing classical culture models. We propose to develop platforms and test their edge over classical approaches in decoding the role of exosomes and μEnv in NB. Our μBRs generate time and space-resolved concentration gradients, support fast dynamic changes and reconstruct complex interactions between cells and tissues while performing multifactorial and parallelized experiments. We expect that our technologies will bridge the gap between in vitro techniques and in vivo biological phenomena leading to significant and novel results, shedding light on previously unexplored scenarios.

Keywords: micro system engineering
Coordinated Research in Earth Systems and Climate: Experiments, kNowledge, Dissemination and Outreach (CRESCENDO)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Germany,Germany,Italy,Italy,Switzerland,Norway,Sweden,Sweden,Norway,Finland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Advanced Earth-system models (H2020-SC5-2014-two-stage, 2014)
Start date: 2015-11-01
End date: 2021-03-31
Duration (months): 65.0
Total project cost (EUR): 15003511.25
EU funding (EUR): 14338876.25
Participants: 28
Project status: CLOSED

CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system projections; (ii) develop and apply a community ESM evaluation tool allowing routine ESM performance benchmarking, process-based ESM evaluation and the analysis of Earth system projections. The resulting tool will be installed and made openly-available on the Earth System Grid Federation (ESGF); (iii) further develop the discipline of emergent constraints in order to better constrain the representation of key biogeochemical and aerosol feedbacks in ESMs and thereby reduce overall uncertainty in Earth system projections; (iv) quantify the effective radiative forcing of key biogeochemical and aerosol feedbacks in ESM projections; (v) contribute to the development of a new set of combined socio-economic and climate emission scenarios that more explicitly link future socio-economic development pathways with global radiative forcing; (vi) apply the project ESMs to these new scenario data to generate an ensemble of Earth system projections for the coming century and, in combination with the underlying socio-economic scenarios, use these projections to assess joint risks and co-benefits related to climate change, climate impacts, adaptation and mitigation; (vii) ensure data produced by CRESCENDO is available to the international community through timely archival on the ESGF and work closely with climate impact assessment and regional downscaling teams to ensure maximum uptake and use of these data in such complementary areas of science; (viii) actively disseminate knowledge generated in CRESCENDO to fellow scientists, policymakers and the general public.

Keywords: earth system modeling,evaluation and projections,integrated assessment modelling,socio economic scenarios
Enhancing decision support and management services in extreme weather climate events (beAWARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Spain,Israel,Spain,Italy,Germany,Finland,Greece,Denmark
Call: Crisis management topic 1: potential of current and new measures and technologies to respond to extreme weather and climate events (H2020-DRS-2015, 2015)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 6725209.0
EU funding (EUR): 5953780.0
Participants: 11
Project status: CLOSED

In every disaster and crisis, incident time is the enemy, and getting accurate information about the scope, extent, and impact of the disaster is critical to creating and orchestrating an effective disaster response and recovery effort. The main goal of beAWARE is to provide support in all the phases of an emergency incident. More specifically, we propose an integrated solution to support forecasting, early warnings, transmission and routing of the emergency data, aggregated analysis of multimodal data and management the coordination between the first responders and the authorities. Our intention is to rely on platforms, theories and methodologies that are already used for disaster forecasting and management and add the elements that are necessary to make them working efficiently and in harm under the same objective. The overall context for beAWARE lies in the domain of situational awareness and command and control (C2). The first phase concerns the forecast of the extreme condition and the relevant preparations. Once a disaster occurs, an initial assessment needs to be conducted as soon as possible to determine the scope, geographical distribution, and scale of the incident. Situational awareness means being able to accurately determine what has happened, what is happening now, and what will come next, all in order to plan and coordinate the most effective response possible with the resources available. This observation phase will lead to an orientation phase suggesting both an individual as well as collective “cognition” orientation to data that is sensed and communicated. Once orientation to the data (or the lack of it) occurs then a decision is made, ultimately resulting is the final step, which is “act”. The crisis management center is always striving or struggling to gain a sense of what is reality to be able to feel that he or she can make a decision that is the "best possible" given the circumstances.

Keywords: security,crisis management,early warning system,psap
FLEXOELECTRIC SCAFFOLDS FOR BONE TISSUE ENGINEERING (FLEXOBONEGRAFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-15
End date: 2019-10-03
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Bone is the most transplanted tissue with 1.3 million procedures every year in Europe. With an increasing demographic ageing across Europe, bone transplant represents a significant socio-economic burden that necessitates new bone regeneration strategies in line with one of the Horizon 2020 priority: "Smart Growth: knowledge and innovation based economy". The field of bone tissue engineering has flourished over the last decades, owing to a solid knowledge on bone biology and increased progress on materials engineering. A few weeks ago, Dr Gustau Catalan at ICN2 brought to light the groundbreaking discovery that bone is flexoelectric. In order to biomimic the flexoelectric character of bone, we aim in this project to produce new synthetic bone scaffolds that exhibit flexoelectricity. Engineering scaffolds with a flexoelectric character calls for particular design requirements. Flexoelectricity is the coupling between strain gradients and polarization, whereby any dielectric can polarize in response to an inhomogeneous deformation. In order to generate the required strain gradients within the scaffold to produce a flexoelectric effect, scaffolds will be manufactured with controlled porosity gradients by 3D printing based approaches. Three polymers used in bone tissue engineering, namely PLLA, PLGA and PCL will be investigated to produce the flexoelectric scaffolds. It is envisaged that a flexoelectric-induced polarization can be attained in any of them. In view of improving the osteoconductive, osteogenic and mechanical properties of the flexoelectric scaffolds, they will further incorporate different amounts of nanohydroxyapatite (from 0 to 50 wt %). Finite element calculations will be used to refine porosity geometries (porosity gradient and pore shape). It is expected that through careful geometrical design of porosity, scaffolds could exhibit a bone-like flexoelectric effect that would not only support the bone tissue regeneration process but also stimulate it.

Keywords: functional materials,flexoelectricity,bone tissue engineering,scaffolds,polymer science,3d printing