Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Miro dependent mitochondrial dynamics and the regulation of neuronal migration (MiroMigration)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-04
End date: 2018-04-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Regulated trafficking of mitochondria is essential for providing ATP at the correct spatial location to power neural computation, and for providing Ca2+ buffering at sites of Ca2+ entry or release. In neurons, the concentration of mitochondria in specific regions such as growth cones and synapses is important for correct neuronal function and development. Consequently, defective mitochondrial trafficking is increasingly implicated in neurological diseases. Very little is known regarding the role of mitochondrial positioning and function during neural development such as during the migration of cortical neurons. This proposal will study the mechanisms that control the trafficking of mitochondria in neurons and how this regulates neuronal migration during cortex development. Using imaging, molecular techniques, combined with ex vivo or in utero electroporation and mouse transgenic models I will determine the molecular mechanisms underlying the signalling-dependent positioning of mitochondria in migrating neuronal progenitors. I will examine how the mitochondrial Ca2+-sensing GTPase Miro1 acts as a molecular switch to regulate mitochondrial positioning and function. How Miro1-mediated mitochondrial trafficking regulates neuronal migration in brain development will also be determined. A key goal will be to determine the role of Miro1 Ca2+-sensing and GTPase domains and other components of the Miro1 protein complex including CENPF, DISC1 and Nde1 in the control of mitochondrial positioning in these processes. These studies will significantly advance our understanding of the molecular mechanisms that control mitochondrial signalling-dependent localization in regulating neuronal development. Moreover, understanding these processes may highlight novel therapeutic approaches for neurodevelopmental disorders including Autism Spectrum Disorder, schizophrenia and intellectual disability, where disrupted neuronal migration and cortical wiring are thought to occur.

Keywords: mitochondria,miro,rho gtpase,neuronal migration,calcium signalling,atp levels
Government of Life and Death: The Rise of Coercive Power in European Late Prehistory (CoPOWER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

CoPOWER will adopt state-of-the-art archaeological and bioarchaeological approaches to investigate the transition to urban society and the rise of increasingly sophisticated social control mechanisms in Europe 1200-500 BC. The rich burial record of Austria and northeast Italy is used as a case study. Many research projects have investigated social complexity and urbanization in the study area by focusing on the elite groups that supposedly spearheaded these processes; by contrast, CoPOWER will explore the life-histories of the marginal individuals that are often the forgotten victims of history. In doing so, it will (a) contribute to develop an analytical framework for identifying and assessing potential bioarchaeological correlates of social change and disruption in the mortuary record of any given society and (b) promote marginality studies in archaeology. These aims will be achieved by building upon the ER's previous expertise in archaeological theory, in conjunction with the new skills in human osteology, isotope and DNA analysis she will acquire over the MSCA. Through high-quality training at OREA and the Natural History Museum in Vienna, the ER will not only learn about human skeletal biology and various analytical and laboratory procedures, but also how to interpret the data resulting from these methods within a broad, comparative anthropological framework for bioarchaeological problem-solving. Collaboration on OREA’s ECR-funded project The Value of Mothers to Society will also provide crucial training in project management and added-value knowledge on the gender dimension of inequality in Europe’s late prehistory. The contributions of CoPOWER to understand the processes leading to social change and marginality under socio-environmental stress are extremely timely in today’s worldwide order; its results 'will therefore fulfil the Horizon 2020 Programme’s aims to promote EU excellence through top research across Europe and through a knowledge-based society.

Keywords: bio archaeological approaches to social marginality,funerary evidence,late bronze age and iron,age 1200 500 bc,social exclusion,transition to urban society in europe
Novel premium pre-filled syringe plunger made by micro- /injection moulding for innovative drug delivery systems and auto injectors (miPLUNGER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global pre-filled syringes (PFS) market has currently a volume of more than 4 billion USD and is growing with a CAGR of 10% due to the increase of chronic diseases, growing demand of biologics and biosimilars and a high penetration rate of autoinjection devices. The segment of autoinjectors grows even faster with a CAGR of 24%. But there are challenges, that cannot be fully solved by the current generation of rubber syringe plungers. Biologics are very sensitive to any leachables, that can be extracted from the syringe components. Self-injection devices need an excellent gliding behaviour of the plunger to minimise patients pain-experience during the injection. The innovative miPLUNGER can solve these challenges by introducing a cost-efficient two component TPE/PFA plunger element, that is manufactured in a reliable two-step micro injection moulding process. The new material is inherently free of any harmful leachables and provides excellent gliding behaviour. The process allows a cost-efficient sterile production under cleanroom conditions in just two process steps and a high flexibility in the plunger design. MDX’ customers are the PFS manufacturers, the primary users of miPLUNGER will be producers of sensitive high-value drugs and those of advanced self-injection devices. MDX will cooperate with them early in their drug and device development to create a growing market for miPLUNGER. By making and selling its new plungers to the PFS producers, MDX anticipates a turnover of 9.6 million €, and an total staff headcount of 28 employees in 2024. In the feasibility study, a detailed analysis of the best-fitting market segments will be conducted, including the cooperation with pilot customers for the validation of the business idea, as well as the elaboration of a thorough business plan for commercialisation. The results of the feasibility study will be integrated into the subsequent SME Phase 2 project to facilitate the commercial launch of miPLUNGER.

Keywords: plunger,syringe plunger,plunger tip,pre filled syringe,auto injector,wearable injector,biologicals,biosimilars,sensitive drugs,high value drugs
Compact Helical Arranged combustoRs with lean LIFTed flames (CHAiRLIFT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy,Italy,France
Call: Innovative NOx Reduction Technologies (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-01-01
End date: 2022-11-30
Duration (months): 47.0
Total project cost (EUR): 1277933.75
EU funding (EUR): 1277933.75
Participants: 4
Project status: CLOSED

The main objective of the CHAiRLIFT project is to assess an innovative combustor concept capable to achieve an ultra-lean, low NOx, operation of future engines. With this combustion concept the requirements of ACARE Flightpath 2050 will be fully satisfied. The CHAiRLIFT combustor concept comprises two novel features: The first is to adopt “low swirl” lean lifted spray flames which feature a high degree of premixing and consequently significantly reduced NOx emissions. Inherent characteristics of such flames are the strongly reduced risk of flashback and a reduced susceptibility to thermo-acoustics instabilities compared to conventional swirl stabilized flames. However, such lifted flames bear the risk of lean blow out at some operating conditions. As second novelty of the CHAiRLIFT concept an alternative approach to standard flame piloting is proposed, enabling a a further reduction of NOx emissions. Stable and safe operations of the combustor are ensured by the interaction of adjacent flames in circumferential direction within the annular combustion chamber. This requires tilting of the axis of the flames relative to the axis of the machine. This design is called Short Helical Combustor (SHC). It has the advantage that no extra pilot flame is required which may produce additional NOx emissions. Additional benefits are the reduced length of the combustor. Most importantly, the turning angle of the NGV can be reduced resulting into a smaller number of NGV and hence reduced cooling air requirement. Experimental and numerical investigations including the development of an advanced spray atomization model will be carried to assess the NOx reduction capabilities of the concept, by exploiting state of the art methodologies. To explore further NOx reduction capabilities of the concept, an advanced LBO active control will also be tested by combining ion sensor probe and plasma assisted combustion.

Keywords: lean burn,lifted spray flames,helical arrangement,advanced spray modelling,ion sensor probe,plasma assisted combustion
Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks (Photonic Radar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-25
End date: 2021-09-24
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The conventional radar systems, operating in mm-wave (MMW) i.e. beyond 30 GHz, are exposed to high free-path losses (≥ 1 dB/km) and the situation becomes more punitive under severe environment conditions, for instance, Heavy rain and fog. Moreover, the traditional radar distribution networks are realized with conventional cables or space-feeds that results in a massive, complex and inflexible system. To overcome these issues, the hybrid photonic-based radar system (PHRAD) emerges as a promising candidate, providing low-loss, immunity to EM interference and high bandwidth capacity. These robust properties of photonics play a vital role in realization of PHRAD transceiver with improved navigation and detection. Although, the possibility of multiband PHRAD, capable to work in both S-and X-band, becomes feasible that reduces the weight, size and cost of the system. Alternatively, the state-of-the-art electronic techniques have not the required potential to make such radars feasible. The key goal of the proposed project is to develop a PHRAD transceiver tunable over a wide frequency range (≥ 40GHz) and immune to phase fluctuations in order to realize a robust navigation and detection system capable of providing high imagery-resolution and accuracy. The proposed work will be carried out in three phases. In phase I, Mode lock Lasers will be cultivated to generate wide-range and phase-stable radar signals in MMW. These wide-bandwidth signals (40-80GHz) will help to provide high imagery-resolution with accurate speed-computation of objects that lead to a reliable and secure navigation to the autonomous vehicles. In phase II, a multiband PHRAD transceiver will be designed to provide high frequency-flexibility that provides capability to track any frequency signal within S-or X-band. The phase III is dedicated to the implementation of the developed multiband PHRAD in real-time environment, especially in intelligent transport system (ITS), for its testing and evaluation.

Keywords: experimentation designing,real time implementation,radar
Asynchronous Trustworthy Transactions (AT2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2021-06-30
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Although Nakamoto’s original blockchain protocol has spurred significant innovation and financial interest in the last decade, its energy consumption becomes problematic. Besides, transaction latencies are prohibitively high and the system sustains a very low throughput. We have witnessed hundreds of alternative solutions in the last decade. Each seeks to reduce energy consumption, to obtain lower latency, or to improve throughput. All proposed alternatives, however, sacrifice either trustworthiness or efficiency. In retrospect, this is not surprising. All these solutions seek to solve a notoriously difficult problem: consensus. In short, the set of nodes in the network have to agree on the same position of a block in the chain, despite the possibility of malicious behaviour of some of the nodes, or network delays. The consensus problem has been the most studied problem in distributed computing, and many impossibility and lower bound results were established. These results translate into inherent trade-offs between trust and efficiency. In the context of our ERC AOC (Adversary-Oriented Computing) project (advanced grant), we worked on classifying distributed computing problems according to their hardness. While doing so, we revisited the issue of implementing a trustworthy payment system, i.e., the problem solved in Nakamoto’s paper. This led us to a very interesting discovery: Current blockchain protocols are tackling a problem, i.e., consensus, which is unnecessarily strong for their purpose of building a payment system. More specifically, we have shown that it is enough to solve a problem called secure causal broadcast to implement trust in any tokenized application. This is significantly simpler than consensus. We devised a generic asynchronous protocol to solve the secure causal broadcast problem, which we called AT2, Asynchronous Trustworthy Transactions, which we patented. The goal of this project is to pave the path to its commercialization.

Keywords: decentralization,trust,asynchrony,blockchain,transactions
Inventive forecasting tools for adapting water quality management to a new climate (inventWater)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Ireland,Ireland,Austria,Germany,Spain,Belgium,Netherlands,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4021497.72
EU funding (EUR): 4021497.72
Participants: 10
Project status: SIGNED

Long-term climate change, extreme events, and seasonal variations in weather have profound impacts on water quality of rivers, lakes, and reservoirs. This implies a pressing need for tools anticipating the impacts of these environmental changes, and enabling effective water management that safeguards the ecosystem goods and services freshwaters provide. The increasing availability of new meteorological data products and advances in modelling tools now mean that it is possible for the first time to produce reliable forecasts for lake and river water quality on a regional and global scale, an unexploited potential in the water sector. Water managers will therefore profit from the education of a new generation of interdisciplinary trained professionals able to bridge fields such as data science, climate, hydrology, and freshwater ecology, who at the same time develop the necessary skills to translate knowledge and technical novelties into products useful for managers, policy-makers, and the general public. The primary objective of inventWater is to organize a platform providing cutting edge cross disciplinary education of tomorrow's water experts. The core activity is the training program, focused on the development and real-world application of inventive water quality forecasting tools across a range of time-scales, to support fast and reliable decision making as well as long-term adaptation policies. inventWater will bring water quality forecasting to the forefront of the scientific disciplines supporting water managers and policy-makers to design measures for adaptation to a new climate. The composition of the network and the multidisciplinary of the PhD projects will make tools developed by inventWater fellows applicable to a wide range of pressing water quality issues, from local adaptation to increases of climatic extreme events, to supporting adaptation strategies to climate change and achievement of UN Sustainable Development Goals.

Keywords: water quality,forecasting,projections,seasonal prediction,isimip,extreme events,lake,catchment,anoxia,fishes,water governance,adaptation,un sustainable development goals
SCIENCE HOTEL 'HUMANIMAL' (SCIHO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-04-01
End date: 2022-01-31
Duration (months): 10.0
Total project cost (EUR): 146750.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Science Hotel is a one-week hybrid (online and onsite) festival, where the general public in Rotterdam and its region meets with scientists and is introduced in their research and its relevance for daily life. 'Humanimal', this year's theme of Science Hotel, features scientific aspects of the relation between human society and nature. Presently, this relation is relevant in dealing with the Corona/Covid-19 crisis, since the emergence of the pandemic has its origins in the animal world and public and social strategies for coping with the crisis touch upon psychosocial mechanisms originating in the evolution. Understanding the scientific aspects of this relation will help society and individuals to develop strategies for resilience. Researchers participating in Science Hotel will reflect on these aspects. The program of Science Hotel will address climate and environmental challenges with presentations of research in sustainability and transition within the context of the European Green Deal. Science Hotel facilitates personal and interactive encounters between the audience and researchers. It invites the audience to step into the daily life of researchers and discuss research topics and their perception by societal stakeholders. This dialogue is stimulated, enriched and sometimes distorted, by artists' interventions. The program kicks off during the week before European Researchers’ Night with online and offline pre-events for school classes, teachers and families. During the NIGHT itself, audiences are welcome in Science Hotel, a festival of science, art and entertainment. Science Hotel is directed to a general public with a broad interest in science, technology, innovation, art within a societal context. It especially targets a young adventurous public in the age of 19 to 39 years old; teachers, school pupils and students; families with children in the age of 15 to 21 years old; stakeholder groups of invited researchers and researchers themselves.

Keywords: science communication,science hotel,co creation,general public,one health,green deal
Automated inspection tool to unveil defects in raw Gallium Nitride (GaN) and Silicon Carbide (SiC) crystals. (GaNSpector)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Gallium Nitride (GaN) and Silicon Carbide (SiC), in particular the 4H hexagonal polytype of SiC (4H-SiC), are wide bandgap semiconductors with significantly superior electrical and thermal characteristics compared to Silicon. Both materials are key enablers for ongoing changes in electric utility and transportation infrastructures. Commercial products that significantly benefit from GaN and SiC semiconductors include solid-state energy converters, power management electronics, power amplifiers, light-emitting diodes, displays, solar cells, lasers, and environmental sensors. Recently, the development of GaN and SiC-based devices has highly accelerated because of their potential for 5G technology. The high defectiveness of produced crystals is one of the principal obstacles to expanding GaN and 4H-SiC use. Therefore, tools for more efficient GaN and 4H-SiC production are highly requested. The Swiss company Scientific Visual has already developed quality inspection tools for raw Sapphire industrial crystals and is expanding its technology to GaN and 4H-SiC. This project aims to develop an automated non-destructive inspection tool to help semiconductor manufacturers to get insight into raw GaN and 4H-SiC crystal quality. Such a scanner will help improving the growth process and assessing the defectiveness of GaN and 4H-SiC crystals before processing. It will save resources on slicing and polishing initially defective crystals, and thereby time and costs to fabricate epi-ready wafers.

Keywords: gallium nitride,crystal inspection,defects visualization tool,tomography,semiconductors,optics