Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Data Aware Wireless Networks for Internet of Everything (DAWN4IoE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,China,Greece,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-12-01
End date: 2023-09-30
Duration (months): 70.0
Total project cost (EUR): 1107000.0
EU funding (EUR): 850500.0
Participants: 10
Project status: SIGNED

Whilst traffic demand is increasing exponentially, network operators’ revenue remains flat. There is an urgent for data driven 4G/5G networks. In this project, we exploit heterogeneous big data analytics to optimize both the deployment and operations of wireless networks. We design protocols that enable future Data Aware Wireless Networks (DAWN) for enabling a new age of Internet of Everything (IoE). The proposal has been developed to address the following open issues in data driven flexible systems: • How to characterize user mobility and wireless data traffic patterns • How to infer user Quality-of-Experience (QoE) from combining data sets • How to use data analytics to assist cell planning • How to use data driven techniques to optimise the network using Self-Organising-Network (SON) algorithms • How to optimally cache data to accelerate and optimise data storage and transmission. The research objectives of the DAWN4IoE project are as follows: • Develop appropriate spatial-temporal structured filters to combine different data sets and infer both human location/mobility and digital data demand patterns. • Develop appropriate machine-learning techniques for unstructured natural language processing (NLP) to understand consumer experience for different service categories. • Design algorithms to integrate the new data analytics techniques with current state-of-the-art deployment techniques to assist HetNet planning, performance prediction, and deployment • Design mechanisms to integrate structured and unstructured data analytics to drive SON algorithms for radio resource management and smart antenna elements. • Design algorithms to optimally cache data leveraging on mobile edge computing (MEC). Achieving the above objectives will provide crucial inputs for 5G/B5G data-driven flexible wireless network design and both increase network capacity by 50% and decrease operation costs by 20-30% (compared with non-data driven networks).

Keywords: data analytics,radio access network,network planning,network optimization,internet of everything
Sociocomplexity — new paradigms for understanding complex group-level adaptation (SOCIOCOMPLEXITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1968688.0
EU funding (EUR): 1968688.0
Participants: 1
Project status: SIGNED

Natural selection explains the appearance of design in the living world. But at what level is adaptive design expected to manifest (gene, organism or society) and what is its function? Adaptation may manifest at multiple levels, and indeed new levels of adaptive individuality may evolve over time – such as with the emergence of multicellularity and eusociality. However, understanding the forces that drive such “major transitions” remains a challenge: current theory, with its focus on single, simple traits, has been unable to engage with issues of complex, coordinated adaptation at the level of the group, and this has led to a striking mismatch between theory and data. In particular, there is currently very poor understanding of what drives conflicts within groups and how group-level adaptation can sometimes prevail despite these conflicts. My research team will develop new theoretical and in silico experimental paradigms for studying complex, group-level adaptation to resolve these problems. We will: (1) synthesize the theories of inclusive fitness and multilevel selection to allow direct engagement with complex adaptive design at multiple levels of biological organization; (2) take a geometric approach to social adaptation to determine how complex, multidimensional phenotypes evolve in the context of social conflicts; (3) develop a computational paradigm for group-level adaptation in which complexity may be quantified and tracked over evolutionary timescales; and (4) employ genomic imprinting as a tractable model of major transitions, to understand how conflicts of interest arise and how they resolve to maintain or disrupt the adaptive integrity of the organism, with applications to childhood cancers and growth, fertility and neurological disorders. This research will yield novel insights into the fundamental drivers of complex adaptation at the level of whole organisms and successful societies.

Keywords: adaptation,darwinism,fitness,group selection,inclusive fitness,kin selection,major transition,multilevel selection,social evolution,superorganism
Highly accurate, flexible, robust and scalable multicamera system for spacecraft autonomous attitude determination through low cost cameras (ARGO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: Engaging SMEs in space research and development (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2020-10-31
Duration (months): 49.0
Total project cost (EUR): 2808867.5
EU funding (EUR): 1966207.25
Participants: 2
Project status: CLOSED

The project addresses the sector of Spacecraft Attitude Determination from star measurements which is a critical element of the Attitude and Orbit Control System for any spacecraft. Nowadays the need of high accuracy for demanding satellite missions is achievable through high-quality star trackers, but high costs and lack of flexibility are still a gap to overcome for covering the needs of emerging space markets, like the ones related to low mass and size satellites, called SmallSats. The Consortium, composed by two high tech Italian SMEs, intend to pave the way towards next generation star tracker systems by proposing a disruptive innovation for this sector: ARGO, an innovative multicamera system for spacecraft autonomous attitude determination by means of star observation, able to offer high flexibility, robustness, accuracy, scalability and significant reduction of production costs compared to products currently on the market. ARGO's main advances with respect to the state-of-art have been conceived, developed and successfully tested by EICAS in previous R&D activities. ARGO is ready for TRL6, having proved ARGO feasibility in relevant environment at TRL5 - through a preliminary night sky test campaign - by means of a prototype based on low-cost industrial cameras. The purpose of this proposal is to accomplish the following steps necessary for fully exploiting the ARGO potential and reaching the commercialisation stage: • from the scientific/technical point of view, to bring the ARGO technology readiness level up to TRL9, by developing a system completed and "flight qualified" through significant tests and demonstrations both ground and flight In Orbit Demonstrations (IOD) • from the business point of view, to take the necessary actions with end-users and relevant stakeholders to accelerate and maximise the impact of the proposed disruptive innovation and to actuate the Consortium business strategy to reach the market.

Keywords: autonomous attitude determination,multicamera,flexibility,robustness,high accuracy,scalability,significant reduction of camera production costs,on board calibration,in orbit,demonstration
Dissecting Rho GTPase signalling networks through acute perturbation techniques (RhoSNATCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Recent advances in technologies to measure Rho GTPase signaling with unprecedented spatiotemporal resolution in single living cells have led to novel questions. Important new insights are that Rho GTPase signaling involves the formation of signaling complexes that fluctuate on subminute time and micrometer length scales, and that complex signaling networks involving multiple Rho GTPases fine tune the leading edge dynamics that power fibroblast migration. Novel methodologies are required to dissect this newly discovered signaling complexity. RhoSNATCH aims to characterize these signaling networks by acutely perturbing and recording Rho GTPase signaling at biologically relevant timescales in live-cell imaging experiments of cell migration. I will identify the crosstalk between Rac1/RhoA/Cdc42 that positions and maintains specific Rho GTPase activity zones in time and space and identify dedicated functional signaling modules that fine tune specific cytoskeletal output at the leading edge of motile fibroblasts. Microfluidic technology will be used to induce precise fibroblast leading edge signaling states. Genome editing in combination with a reversible chemical dimerizing system will be used to acutely perturb endogenous RhoA,Cdc42 and Rac1 signaling, as well as a subset of their upstream regulators that regulate leading edge dynamics. Rho GTPase activation patterns and downstream cytoskeletal outputs will be systematically recorded in the different perturbed states. Computer-vision assisted image analysis will allow the multiplexing of multiple data sets to produce one of the first integrated models of the molecular circuitry that fine-tunes Rho GTPase signaling and cytoskeletal dynamics during leading edge extension. This novel, integrated approach will allow for the first time the identification of different spatiotemporally organised Rho GTPase signaling modules, and give relevant insight into the crosstalk between and functions of Rho GTPases in time and space.

Keywords: rho gtpases,chemical biology,crispr cas9,cellular imaging,cell migration
Facilitating EU pre-Standardization process Through stReamlining and vAlidating inTeroperability in systems and procEdures involved in the crisis manaGement cYcle (STRATEGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Innovation actions
Countries involved: Austria,Spain,Italy,Germany,Finland,Romania,Greece,Norway,Sweden,Belgium,Greece,France,Netherlands,Netherlands,Portugal,United Kingdom
Call: Pre-normative research and demonstration for disaster-resilient societies (H2020-SU-SEC-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 6833075.0
EU funding (EUR): 5997293.25
Participants: 24
Project status: SIGNED

STRATEGY will develop a pan-European framework of the pre-standardisation activities for systems, solutions and procedures, addressing crisis management, validated by sustainable tests and evaluation frameworks which will improve the crisis management and disaster resilience capabilities, including EDA initiatives in the CBRN-E area. Based on the needs identified from previous EU initiatives and the desktop research on the EU priorities, the project addresses six streams within the Crisis management phasma, such as Critical infrastructures protection, Response planning, Search and Rescue, Command and Control, Early Warning Systems and Rapid Damage Assessment and cross correlates them with six distinctive building blocks of the interoperability areas such as Common Procedures, Training, Terminology, Data sharing and Equipment as well as the CBRN-E emergencies. Aiming at selecting and implementing existing, evolving and new standards within solutions, tools and procedural guidelines and recommendations STRATEGY will streamline and validate technical and organisational interoperability in a fully transboundary configuration with means of standards through the implementation of uses cases involving EU and National Standardisation bodies. STRATEGY aims at a consistent presence of all actively involved experts from security stakeholders throughout all stages of standardisation, from the preparatory work done in Programming Mandates until the concrete standardisation work in Technical Committees (TCs) and Common Working Groups (CWGs) to assure the success of the standardisation actions of the EC. The ultimate project goal is to strengthen the resilience of EU against all types of natural & manmade disasters (multi-hazard approach), by ensuring FR safety and empowering their operational capacity though validating the standards of next generation solutions and procedures ensuring an effective and efficient collaborative response.

Keywords: standards,interoperability,pre normative research
Individual and Collective Swimming of Active Microparticles (CollectSwim)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1497698.0
EU funding (EUR): 1497698.0
Participants: 1
Project status: SIGNED

Bacteria are tiny; yet their collective dynamics generate large-scale flows and profoundly modify a fluid’s viscosity or diffusivity. So do autophoretic microswimmers, an example of active microscopic particles that draw their motion from physico-chemical exchanges with their environment. How do such ``active fluids'' turn individual microscopic propulsion into macroscopic fluid dynamics? What controls this self-organization process? These are fundamental questions for biologists but also for engineers, to use these suspensions for mixing or chemical sensing and, more generally, for creating active fluids whose macroscopic physical properties can be controlled precisely. Self-propulsion of autophoretic swimmers was reported only recently. Major scientific gaps impair the quantitative understanding of their individual and collective dynamics, which is required to exploit these active fluids. Existing models scarcely account for important experimental characteristics such as complex hydrodynamics, physico-chemical processes and confinement. Thus, these models cannot yet be used as predictive tools, even at the individual level. Further, to use phoretic suspensions as active fluids with microscopically-controlled properties, quantitatively-predictive models are needed for the collective dynamics. Instead of ad-hoc interaction rules, collective models must be built on a detailed physico-mechanical description of each swimmer’s interaction with its environment. This project will develop these tools and validate them against experimental data. This requires overcoming several major challenges: the diversity of electro-chemical processes, the confined geometry, the large number of particles, and the plurality of interaction mechanisms and their nonlinear coupling. To address these issues, rigorous physical, mathematical and numerical models will be developed to obtain a complete multi-scale description of the individual and collective dynamics of active particles.

Keywords: active fluids,synthetic microswimmers,collective dynamics,hydrodynamics
Lanthanides as electron Dimmer switch in organometallic catalysis (LanAsCat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1499928.87
EU funding (EUR): 1499928.87
Participants: 1
Project status: CLOSED

Complexes containing redox non-innocent ligands have been well developed in the last decade with transition metal ions and have led to very important chemical transformations at lowest environmental and economic costs. Nonetheless examples with f-element are very rare and the field is almost empty with lanthanides. This is unfortunate since divalent lanthanides are excellent sources of single electron and would provide a good control of the ligand reduction because of strong electron correlation in these systems. Thus, this proposal aims at developing this field with organolanthanides. The synthesis of original complexes containing lanthanides, redox non-innocent ligands and transitions metals is herein proposed: the first providing reversible electron(s) source(s) (remote control), the second acting as electron(s) reservoir and controlling the electron correlation strength (“dimmer switch”), and the last being the site of the selective catalytic reaction. Because of this regulated electron transfer, the oxidation state of the transition metal will be modified only at specific steps, allowing the establishment of a new paradigm is organometallic catalysis with group 9 and 10 transition metals. These original complexes will be synthetized and deeply characterized by specific spectroscopic and theoretical analyses. The principal goal is to synthetize active catalysts toward C-H bonds activation, and methane activation is regarded as an ultimate achievement as is hydroalkylation of olefins. To increase the chances of success, the proposal is based on preliminary results obtained recently in the group. Several examples of original heterobimetallic and heterotrimetallic complexes containing lanthanides and transition metals of group 10 will be discussed as a good starting point for the feasibility of this challenging project that aims at answering a large societal concern: the reduction of atmospheric pollutants, such as methane, and transformation in valuable products.

Keywords: organometallic chemistry,lanthanides complexes,electron transfer,theory,spectroscopy
Protein-excipient Interactions and Protein-Protein Interactions in formulation (PIPPI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Sweden,Sweden,Denmark,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 4067745.48
EU funding (EUR): 4067745.48
Participants: 10
Project status: CLOSED

The revolution of biotechnology has led to the creation of various types of therapeutic biologics with the potential to provide treatment for new chronic and malignant diseases. Though the potential advantages of biologics lay in their high specificity and potency combined with few side effects, their formulation still remains a large challenge to pharmaceutical scientists. This is in part due to the complex, not-well understood relationship between the physicochemical properties of proteins and formulation conditions required for protein stability. A comprehensive understanding of the molecular mechanisms behind protein stabilization and solubility would provide the formulation scientists with knowledge of the interplay between formulation and stability that in turn could potentially make formulation development faster, cheaper and less labour intensive than the currently used broad screening approach. Understanding the susceptibilities of formulations to protein aggregation and denaturation can reduce the response time to for instance product failure. Few universities in Europe have formulation of biologics as a scientific subject. Consequently, the pharmaceutical industry is forced to train scientists - a challenge for larger companies, and an insurmountable task for smaller companies. Scientists in the field of structural biology, biophysics, protein formulation and stability have formed a consortium to systematically map physicochemical properties of biologics, formulation conditions and protein stability. The main objective of the consortium is to provide a new generation of innovative and entrepreneurial early-stage researchers that will develop methodologies, tools and databases to guide the formulation of robust biologics. The consortium will not only provide an excellent platform to train a new generation of formulation scientists, but also establish avenues for designing new formulation strategies and thereby securing the leading edge of EU expertise.

Keywords: protein formulation,excipient binding,protein structure,aggregation,protein protein interactions,protein excipient interactions,drug development,molecular interactions