Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ergodic theory for complex systems: a rigorous study of dynamics on heterogeneous networks (ErgThComplexSys)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: SIGNED

Nowadays, networks of interacting systems appear in many areas of Science such as physics, chemistry, biology and also engineering and the human sciences. Examples range from solid state physics, to astrophysics, reaction-diffusion equations, transportation systems, the Internet, social networks, opinion models, etc. This vast spectrum of applications has stimulated a broad interdisciplinary endeavour to predict and control the behaviour of so-called "complex systems", namely large ensembles of units coupled through an intricate interaction web. While various theoretical and computational approaches to these systems have been developed, from the mathematical perspective, their analysis remains extremely challenging. Very little has been accomplished, especially as the description of the dynamical mechanisms underlying overall functioning is concerned. The proposed project aims to develop a novel rigorous approach to describe the emergence of global behaviour in complex heterogeneous systems, given their microscopic constituents such as individual dynamics and interaction nature/structure. At the interface between pure and applied mathematics, our approach will rely on results from abstract ergodic theory, especially as they have been recently obtained for non-uniformly hyperbolic systems, to address concrete mathematical models exhibiting real-world features.

Keywords: ergodic theory,dynamical systems coupled on networks
Real Time 360 Live Streaming Electric City Auto Tours (LET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-16
End date: 2020-05-15
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Live Electric Tour (LET) is a unique shared experience for the new urban tourist. While you tour a modern Capital in a futuristic and fun electric car you can share in real time a 360o full hd view of the environment and yourself with fans, friends and family. Participant number Organization name Country Value Proposition: By recording and sharing client’s tour you solve their need of taking constant pictures and sharing a video of the amazing eco-experience, enhancing the perceived value and joy while reducing pollution, and enjoying a guided tour by a contextual onboard GPS. Problem to solve/ Value to add: Some European Capitals are dealing with a high pressure from tourism in terms of traffic pollution and to provide a fast intuitive way to visit the main attractions while providing Wi-Fi to all the internet seeking new breed of tourists so focused on the mighty selfie. Opportunity to seize: The New Tourist is looking for different, connected experiences where he can be in control and share his experiences with his social profiles. (Frost & Sullivan | Amadeus) We offer an added bonus: an ecofriendly futuristic looking fun-car for self-driving tours. More than a tour we offer a unique innovative sharable experience.

Keywords: eco tours,sustainable tourism,sharable experiences,urban tourism pressure,electric car tours
Synthesis and validation of chemical Probes for Centrosome Declustering: development of potent and selective anti-cancer agents. (ProCenDecl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cancer cells have the tendency to accumulate extra copies of centrosomes, organelles responsible for the microtubules' organization during cell division. In normal cells, an aberrant number of centrosomes leads to the formation of multipolar spindles, uneven segregation of chromosomes between daughter cells and consequent mitotic catastrophe. On the contrary, cancer cells are able to form a pseudo-bipolar mitotic spindle by a process called centrosome clustering, which provides survival advantage for tumor cells. The specificity of this process can be exploited as a potential novel target for the development of highly selective anti-cancer drugs. The mechanism of centrosome clustering is not completely understood. Particularly, from recent reports it seems that ADP ribosylation factors tankyrase (TNKS1) and ADP-ribose polimerase 16 (PARP-16) have a significant role in the prevention of multipolar spindle formation. Based on these findings and the already druggability of poly (ADP-ribose) polymerase (PARP) enzyme family, a SAR study on phtalazinone PARP inhibitors from AstraZeneca's compound library was carried out. This study led to the discovery of AZ9482, a potent inhibitor of centrosome clustering, and AZ0108 an orally available derivative that is able to potently inhibit PARPs 1/2/6. AZ9482 as well as AZ0108 can be used as a starting point to design and synthesize a first series of chemical proteomics tools, that will allow an extensive investigation of the centrosome declustering mechanism. All currently available technologies in the field of target discovery will be employed, including photoaffinity ligation and biorthogonal conjugation. The acquired knowledge can be used to design novel highly specific and potent anti-cancer drugs that inhibit centrosome clustering with a specific mode of action.

Keywords: centrosome clustering,activity based probes,photo affinity ligation,bioorthogonal conjugation,proteomics
Miniaturized automated patch-clamp system combined with high-density microelectrode arrays for multi-scale functional mapping of neuronal networks (MAPSYNE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

More than one billion people worldwide (165 million in Europe) suffer from diseases of the central nervous system (CNS). With Europe's aging societies, the European Commission identified brain research as one of the key research areas under healthcare (https://ec.europa.eu/research/health/). Many neurodegenerative diseases are still without cure (e.g., Parkinson’s, amyotrophic lateral sclerosis (ALS) and Alzheimer’s) and repeated failures in clinical trials increase the demand for novel screening technologies to be implemented in the early phases of drug discovery. Recent studies show that synaptic dysfunction is involved in CNS diseases. New technologies for neuronal screening targeting synaptic and network activity, combined with disease model cells in vitro, will enable novel functional assays for CNS drug discovery. This project aims to develop MAPSYNE, a Miniaturized Automated Patch-clamp SYstem combined with high-density microelectrode arrays (HD-MEAs) for multi-scale functional mapping of NEuronal networks. Patch-clamp allows detection of synaptic events and action potentials (APs) of single cells, while HD-MEAs record APs of thousands of neurons in parallel (also track APs propagating along axons). Combining the two methods will allow access to neuronal electrical signals across spatial and temporal scales. MAPSYNE's main objectives are (1) the development of hardware and software for a fully automated mini-patching system on HD-MEAs and (2) proof-of-concept experiments using primary and human induced pluripotent stem cell (h-iPSC)-derived neuronal networks. MAPSYNE will be designed for long-term, label-free recording of cell cultures. Other applications include local application of drugs (e.g, synaptic blockers on neuronal compartments). After this project, the ER envisions the commercialization of MAPSYNE, and eventually, its usage for preclinical CNS drug discovery.

Keywords: patch clamp electrophysiology,multielectrode arrays technology,synaptic activity,network connectivity mapping,human induced pluripotent stem cell derived neurons,axons
Individualised and self-adapting sound processing for cochlear implants (ISIFit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 1734360.0
EU funding (EUR): 1734360.0
Participants: 1
Project status: CLOSED

Cochlear implants (CIs) are successful auditory prostheses that enable people with deafness to hear through electrical stimulation of the auditory nerve. In a CI sound processor, a sound signal is converted into a sequence of electrical pulses. This conversion entails many parameters that should ideally be fine-tuned (fitted) for every individual patient, to account for various anatomical and physiological differences. In current clinical practice, devices are fitted during the initial rehabilitation and yearly thereafter. As fitting is very time consuming, only the bare minimum number of parameters is fitted individually. However, for many other parameters, for which currently the same default values are used for all patients, better speech understanding can be achieved with individual fitting. Apart from the fitting, CIs do not take into account the neural or perceptual effects of stimulation. The objective of this project is to provide better fitting to individual patients by developing a closed-loop CI that automatically adjusts its fitting and sound processing based on the neural response to speech. To achieve this, we will (1) objectively measure speech understanding, by recording the electroencephalogram (EEG) in response to ecological speech signals, (2) automatically fit a wide array of sound processing parameters accordingly using a genetic algorithm, and (3) develop a wearable closed-loop CI that continuously records the EEG and adjusts the fitting in real-life situations. This will lead to a better understanding of speech perception of people with a hearing impairment, an objective measure of speech intelligibility with many applications in diagnostics, a method to automatically fit CIs, and a novel closed-loop CI. For the patient this means improved speech intelligibility in noise and therefore better communication and quality of life. For the clinic this means improved efficiency and the ability to better fit devices.

Keywords: cochlear implant,evoked potentials,speech intelligibility,automatic fitting,objective measures,genetic algorithm,closed loop
Power and Powerlessness (PWP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The project ‘Power and Powerlessness’ (PWP) is a theological study of the concept of power. Many scholars have observed that the concept of power remains contested and often neglected. The absence of a theoretical grasp of the concept is even more striking in Christian theology. Churches in the Global North evidence considerable discomfort over the idea of power: to avoid the charge of colonial imposition of their world-view; due to conflicts over authority within the churches; or to dissociate from the dominant political order. In the Global South, however, the vibrant Neo-Pentecostal and Charismatic movements celebrate the immediacy of the ‘power of the Spirit’. What needs to be better understood are the resources contained within the Christian tradition to make sense of competing claims about the nature and significance of power, particularly given that existing literature does not often address these issues in a sustained manner. The fill this gap, the project is organized into four work packages: WP1: Early, Medieval and Early Modern Christian concepts of power; WP2: contemporary theological treatments of power; WP3: Power in contemporary social theory; WP4: the completion of a monograph entitled 'Power and Powerlessness: a theological analysis'. In addition to this major study, the project will produce: five journal articles, four workshops for church leaders, three columns for church newspapers, three academic conference presentations, a project website, and a new collaborative research grant application with the Scientist in Charge. The Experienced Researcher will not only benefit from training in research project management and grant writing, but will also be mentored in Historical, Systematic and Roman Catholic theology, as well as Philosophy of Religion, and will enhance his existing German language skills. The host institution will benefit particularly from the ER’s highlighting of issues of power as he contributes to its existing research projects.

Keywords: power,authority,church conflict,powerlessness
Co-creation better SME support through improving the process of investments in innovative ideas (INNOINVEST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Spain,Poland
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2021-02-01
End date: 2022-01-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 4
Project status: CLOSED

The main goal of this project is to increase the agencies efficiency in the field of capital investment management and financial support for innovative SMEs that are launching new innovative products/technologies (R+D) by finding tools and methods to improve the investment process, especially by facilitating the SMEs cooperation with corporate companies. Four innovation agencies (IAs) will work on the whole investment process for SMEs’ innovative technologies/solutions to ensure the best quality in the selection of the SMEs and their management staff and proposals. The IAs will also pay attention how to choose the best qualified and experienced experts to the process of evaluating ideas. Besides, the main emphasis will be put on the validation process in order to ensure the SMEs feedback from the potential business partners and facilitate them to start the cooperation with corporates companies and acquire the financial (short or long term) support. Innovation agencies involved in the project will work using twinning+ methodology in order to create valuable Design Options Paper regarding whole investment process including the selection of the SMEs, evaluation, validation leading to obtain the capital by SMEs. The new approach to investment process run by IAs can strengthen the position of innovation centres on the national and international arena as a high value added business support organisations regarding investment area and can limit the risk of investment in highly innovative SMEs solutions. The result of peer learning activities delevoped in the Design Option Paper will be implemented in the agencies as improved investment programmes and will be put into practice by IAs. The results of the project can enhance also the possibilities of obtaining by SMEs not only the short but also the long-term capital from business and financial partners what can enhance SMEs growth, competitiveness and facilitate their focusing on profitability of innovative solutions.

Keywords: investment process,innovation,smes support,innovative solutions,business and financial partners
ECO-INNOVATIVE WATER-BASED INKS FOR THE CERAMIC SECTORS (ECO-INK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ECO-INK project proposes a green, innovative and comprehensive solution to the great limitations of the digital printing technology within the ceramics decoration sector. The main objectives of the project are to explore new market opportunities and boost the competitiveness of METCO srl business, while addressing EU/global challenges on Climate Change and following the indications of the “Stockholm Convention on persistent organic pollutants” & the "Stimulating technologies for sustainable development: an environmental technologies action plan for the European Union": ECO-INK will promote environmentally-friendly activities as well as guarantee the safe elimination of substances, harmful to human health and the environment, as well as the reductions in their production and use, through the substitution of current solvent based ink with water based inks (WSI) for ceramic tile production. for METCO itself, with the introduction of WSI in their production chain, there will be a saving of about 240-360t of solvent each year, corresponding to save about 0,5-1M€ if the solvent substituted is naphtha and approximately 728–1,093t of CO2 emissions per year. Considering the global market the expected figure is very impressive, since it’ll be possible to save 620,000t CO2 emission per year. METCO srl foresees a 2-years investment (about 1.8M€) to complete the optimization of WSI and to setup the whole technological package. METCO then envisages a full production and commercialization of 450-1.350-2.700t ECOINK ecoformulations per Years 3-4-5. This is expected to result in a +487% ROI by 2019 and in a METCO srl growth with +45 human resources by 2021.

Keywords: water based ink,digital printing,ceramic sector,tile surface,green business
Multi-purpose/Multi-sensor Extra Light Oceanography Apparatus (MELOA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Spain,France,Portugal,Portugal,Portugal,Portugal,Portugal
Call: Novel in-situ observation systems (H2020-SC5-2017-OneStageB, 2017)
Start date: 2017-12-01
End date: 2022-02-28
Duration (months): 51.0
Total project cost (EUR): 4694844.75
EU funding (EUR): 4694844.75
Participants: 10
Project status: CLOSED

The MELOA project proposes to develop a low-cost, easy-to-handle, wave resilient, multi-purpose, multi-sensor, extra light surface drifter for use in all water environments, ranging from deep-sea to inland waters, including coastal areas, river plumes and surf zones. The device will be developed as an upgrade to the WAVY drifter conceived by the Faculty of Engineering of the University of Porto, which was used to measure the surface circulation forced by wave breaking, including detailed structure of rifts and the littoral drift current (Jorge da Silva et al, 2016). The philosophy of the WAVY drifter will essentially be respected: a small-size sphere with just enough room to accommodate power source, GPS-receiver, communications modules, antennae, sensors and data processor; optimised buoyancy to prevent the drifter trajectory responding to the wind instead of the current, while providing just enough exposure of the antennae to ensure acquisition of the GPS signal at the required rate and reliable near real-time communications. Given the low influence of wind upon the drifters’ displacements, MELOA will provide a cheap effective way to monitor surface currents and surface dynamic features anywhere in the World Ocean. Through equipping the drifters with thermistors at two different levels, the possibility is open for monitoring “near-skin temperature” and near-surface vertical temperature gradients, which will be invaluable for calibration/validation of satellite derived SST fields.

Keywords: novel measurements,cost reduction