Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
innoVative bIo-based chains for CO2 VALorisation as aDded-value organIc acids (VIVALDI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Germany,Belgium,Sweden,Belgium,Poland,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Bio-based industries leading the way in turning carbon dioxide emissions into chemicals (H2020-FNR-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 6969835.81
EU funding (EUR): 6969835.8100000005
Participants: 19
Project status: SIGNED

The valorisation of industrial CO2 emissions is a cornerstone in EU strategies for climate change and circular economy. Bio-based Industries (BIs) are perfect candidates to apply this CO2 valorisation, since they could to turn their biorefineries’ emissions into feedstock and close the carbon loop. Nevertheless, there is still a strong need of reliable and cost-efficient CO2 conversion technologies to make it possible. VIVALDI proposes an integrated solution allowing the conversion of biogenic CO2 into added-value organic acids, powered by ground-breaking advances in CO2 purification, electrochemical catalysis, microbiology, synthetic biology, and bioprocess engineering. The solution comprises 4 main steps: 1. CO2 purification/enrichment from industrial streams and electrochemical reduction to formic acid (FA) and methanol (MeOH) using electrochemical reactors and gas diffusion electrodes. 2. Nutrient recovery (NH4+, Ca2+, Mg2+, K+) from industrial wastewaters using bioelectrochemical systems. 3. Bioproduction of target organic acids using a microbial platform based on specific engineered yeast strains (P. Pastoris), using as feedstock MeOH/FA/CO2 from step 1 and nutrients from step 2. 4. Industrial validation of the bioproduced organic acids (i.e. efficient downstream processing and on-site industrial validation). VIVALDI will use real gas emissions from 4 key BIs and will focus on the bioproduction of 4 industrially relevant organic acids with different applications and market penetration (LA,SA,IA,3-HP). These acids can re-enter the production process flowchart of biorefineries, thus enhancing the sustainability of their current products or even opening new business possibilities. Moreover, VIVALDI’s feasibility will be confirmed also through an integral sustainability assessment (technical, environmental and socio-economic) to ensure that the proposed solution can be adopted and integrated in any biorefinery.

Keywords: pichia pastoris,lactic acid,itaconic acid,3 hydroxypropionic acid,bioelectrochemical systems,electrochemical co2 reduction,nutrient recovery,market adoption,succinic acid,formic acid,methanol
Ancient Music Beyond Hellenisation (AMBH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 775959.0
EU funding (EUR): 775959.0
Participants: 1
Project status: SIGNED

From medieval times, Arabic as well as European music was analysed in terms that were inherited from Classical Antiquity and had thus developed in a very different music culture. In spite of recent breakthroughs in the understanding of the latter, whose technicalities we access not only through texts and iconography, but also through instrument finds and surviving notated melodies, its relation to music traditions known from later periods and different places is almost uncharted territory. The present project explores relations between Hellenic/Hellenistic music as pervaded the theatres and concert halls throughout and beyond the Roman empire, Near Eastern traditions – from the diatonic system emerging from cuneiform sources to the flourishing musical world of the caliphates – and, as far as possible, African musical life south of Egypt as well – a region that maintained close ties both with the Hellenised culture of its northern neighbours and with the Arabian Peninsula. On the one hand, this demands collaboration between Classical Philology and Arabic Studies, extending methods recently developed within music archaeological research related to the Classical Mediterranean. Arabic writings need to be examined in close reading, using recent insights into the interplay between ancient music theory and practice, in order to segregate the influence of Greek thinking from ideas and facts that must relate to contemporaneous ‘Arabic’ music-making. In this way we hope better to define the relation of this tradition to the ‘Classical world’, potentially breaking free of Orientalising bias informing modern views. On the other hand, the study and reconstruction, virtual and material, of wind instruments of Hellenistic pedigree but found outside the confinements of the Hellenistic ‘heartlands’ may provide evidence of ‘foreign’ tonality employed in those regions – specifically the royal city of Meroë in modern Sudan and the Oxus Temple in modern Tajikistan.

Keywords: music archaeology
Counterfactual Knowledge from the Imagination (CKI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 165599.3
EU funding (EUR): 165598.8
Participants: 2
Project status: CLOSED

Thoughts about counterfactual situations are a central feature of human cognition, key to planning in any domain of activity: What would happen if I missed a mortgage payment? What if Britain were to leave the EU? It seems that knowledge about counterfactual situations is possible under some circumstances. The project’s general aim is to improve our understanding of those circumstances, and what role the imagination plays in specifying them. The specific objectives are to investigate: (1) the connection between the epistemology of counterfactual conditionals and the epistemology of claims involving modal terms like “possible”, “necessary”, and “can”, (2) the role of the imagination in the epistemology of thought experiments in science, and (3) the cognitive architecture underlying counterfactual thinking. Over the course of investigating (1)-(3), I develop and defend the view that certain constrained imaginative exercises can provide knowledge about counterfactual situations. I will carry out this research within the interdisciplinary setting of the Institute for Logic, Language and Computation and the Department of Philosophy at the University of Amsterdam. My supervisor Francesco Berto is investigating questions highly relevant to my project’s, especially in his current work that develops a logic of conceivability. I will also make two visits to Oxford Philosophy to discuss my project research with Timothy Williamson, who has made some of the key contributions to the epistemology of counterfactual thinking and the imagination to date. The project will give me the opportunity to establish myself as an important scholar in analytic philosophy. By the project’s end, I will have submitted four articles to internationally leading journals in the field. The project will also enhance cooperation between UvA (ILLC/Philosophy) and Oxford (Philosophy).

Keywords: imagination,epistemology of modality,counterfactual thinking,metaphysical modality,conceivability
Single molecule protein sequencing using biological nanopores (SMPSBN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Despite the importance of post-translational variation to the function of proteins in a living organism, sequencing proteins to study these variations is still a costly and time-consuming process, with intrinsic limitations. Protein sequencing and detection of post-translational modifications (PTMs) by mass spectrometry, the current gold standard, requires extensive sample preparation and large sample sizes, and possesses a limited dynamic range with respect to sample concentration. These limitations severely restrict its application to biological and clinical problems. A robust method for sequencing proteins and detecting PTMs at the single-molecule level would be revolutionary for proteomics research, allowing biologists to quantify low-abundance proteins as well as distributions and correlations of PTM patterns, all at a single-cell level. I propose a first-of-kind method for protein sequencing with applications in fundamental biology, cancer immunotherapy, and pharmaceutical development. This method uses biological nanopores in a manner similar to nanopore DNA sequencing, an established single-molecule sequencing technology capable of high throughput and single-molecule sensitivity. Developing this method for protein sequencing comes with many significant challenges, which will be addressed over the course of the proposed research.

Keywords: protein sequencing,nanopore physics
Personalized immunotherapy in sepsis: a precision medicine based approach (ImmunoSep)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Israel,Austria,Germany,Romania,Switzerland,Greece,France,Netherlands,Netherlands,United Kingdom
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 10081333.75
EU funding (EUR): 10081333.75
Participants: 15
Project status: SIGNED

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and is characterized by a high mortality of up to 30-40%. Treatment of sepsis was revolutionized by two steps that significantly decreased mortality: antibiotics and the intensive care units. It has been hoped that a third revolution, immunotherapy, would further improve outcome of sepsis, but this hope did not materialize. This was due to the incompletely understood pathophysiology, and the heterogeneity of the immune status in different sepsis patients. We propose that while both overinflammation and immunoparalysis are important, they are present in individual sepsis patients.The mission of the present project is to design and perform a proof-of-concept clinical trial of personalized immunotherapy in sepsis, and within this clinical trial, to develop a next-generation theranostics platform for the design of future personalized immunotherapy trials in sepsis. This theranostics platform would be based on an integrated, multidimensional systems biology analysis of omics-based datasets, to identify biomarkers, clinical endotypes, and therapeutic targets for precision medicine approaches. In order to achieve the mission proposed, several complementary aims will be pursued: Aim 1: To design and perform a large personalized immunotherapy trial in sepsis patients, that can provide a clinical answer towards the usefulness of currently employed immunotherapies for sepsis. Aim 2: To chart host genome, epigenome, transcriptome, metabolome and microbiome in at least 180 sepsis patients enrolled in Aim 1 over a defined time course. Aim 3: To use a theranostics approach based on the data provided by Aim 2 to design novel personalized immunotherapeutic strategies. Aim 4: To integrate the clinical and psychological aspects involved when introducing novel immunotherapies for infections in the health care systems of European countries, building bridges with the patient community.

Keywords: sepsis,immunotherapy,precision medicine,interferon gamma,il 1 receptor antagonist
Healthy Apples Research: Valuing Environmental Sustainability of Topsoil (HARVEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-04
End date: 2021-10-23
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The HORIZON 2020 societal challenges highlight the need to innovate on agricultural practices that increase agroecosystem resilience and foster efficient use of available water and nutrients. This is particularly relevant for baby food production systems since there are stringent European regulations that limit the amount of chemical residue levels in baby food. The HARVEST project will develop a novel soil health strategy to decrease the use of chemicals in DANONE’s fruit production systems for baby food that simultaneously enhance soil-borne disease suppressiveness and nutrient/water use efficiency while maintaining fruit productivity. HARVEST will apply biodiversity practices consisting of growing plant species mixtures in the inter-row space between apple trees. I will test the hypothesis that growing inter-row plant species, mulching, and mechanical weeding have a profoundly positive effects on the sustainability of apple orchard topsoils, as measured by soil disease suppressiveness, soil fertility, and water regulation. With HARVEST, I aim to: i) identify the biodiversity practices that enhance below and above- ground apple orchard properties towards a more resilient and nutrient/water use efficiency orchard, ii) develop a soil health strategy to be applied on fruit production systems, iii) enhance partners and societal awareness about DANONEs sustainability programme and its positive action at decreasing chemical use, enhancing food quality, protecting ecosystems and improving human health. Main deliverables will include a list of soil health key performance indicators to advise DANONE on soil management strategies for fruit production systems, soil health traits database for apple orchards and peer-review research papers. Overall HARVEST will guide future agro-food policies to enhance soil ecosystem properties, and promote agriculture less dependent on chemicals.

Keywords: soil quality,soil microbial community,soil fungi,nutrient and water use efficiency,agro ecosystem resilience,baby,infant food
Development and advanced prefabrication of innovative, multifunctional building envelope elements for MOdular REtrofitting and CONNECTions (MORE-CONNECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Estonia,Switzerland,Latvia,Latvia,Czechia,Czechia,Netherlands,Netherlands,Portugal,Portugal,Portugal,Denmark,Denmark,Denmark
Call: Manufacturing of prefabricated modules for renovation of building (H2020-EE-2014-1-PPP, 2014)
Start date: 2014-12-01
End date: 2019-05-31
Duration (months): 54.0
Total project cost (EUR): 5634810.68
EU funding (EUR): 4364748.6
Participants: 19
Project status: CLOSED

Objective is to develop and to demonstrate technologies and components for prefabricated modular renovation elements in five geo-clusters in Europe. This includes prefabricated durable, innovative, modular composed building envelope elements for the total building envelop for the renovation market, including the prefab integration of multifunctional components for climate control, energy saving, building physics and aesthetics, with advanced easy to use plug&play connections (mechanical, hydraulic, air, electric, prefab airtight joints). MORE-CONNECT offers tailor-made renovation concepts, from a standardized industrialized manufacturing and assembly process, in a one-shop-stop concept to the end-user, with a nearly zero energy performance of the total modular renovation concepts, a maximum return on investment less than 8 years and with a limitation of the total renovation time of 5 days. The concept offers performance guarantee for individual energy use and the quality of the indoor environment. Product innovation includes the selection of sustainable materials and sustainable detailing. A specific feature is the development of Plug & Play connection of modular components. Smart combinations of components and executions ensure extra performances for NZE concepts, healthy indoor environment, safety, accessibility. Components communicate by integrated (wireless) sensors and control components for performance diagnostics and control. Process innovation will be achieved by the use of advanced geomatics to make inventories of buildings. Webbased tools will link building characteristics, building (energy) potentials, and end-users demands to program requirements. This will be processed in BIM systems for the steering industrial process and enhanced quality control. This makes it possible to make tailor-made solutions for individuals, in mass production (n =1 series). Business models and advanced energy services (one-stop-shop) will be developed for each geo cluster.

Keywords: modular nze renovation,fully automated production lines,smart connectors,one stop shop concepts for end users
INFORMATION TECHNOLOGIES FOR SHIFT TO RAIL (IT2RAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Italy,Italy,Germany,Germany,Estonia,Italy,Belgium,Belgium,France,France,France,Czechia,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Smart Rail Services (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 12013831.25
EU funding (EUR): 11988831.25
Participants: 38
Project status: CLOSED

The IT²RAIL -“Information Technologies for Shift to rail” proposal, first step towards the long term IP4 -“IT for an Attractive Railway” SHIFT²RAIL Innovation Programme, aims at providing a new seamless travel experience, giving access to a complete multimodal travel offer which connects the first and last mile to long distance journeys. This is achieved through the introduction of a ground breaking Technical Enabler based on two concepts: • the traveler is placed at the heart of innovative solutions, accessing all multimodal travel services (shopping, ticketing, and tracking) through its travel-companion. • An open published framework is providing full interoperability whilst limiting impacts on existing systems, without prerequisites for centralized standardization. This Technical Enabler will be completely settled in the context of the SHIFT²RAIL IP4, and IT²RAIL is proposing a reduced approach to the scale of a specified use case without weakening any of the key concepts of IP4, such as the usage of Semantic Web technologies, meta planning on distributed data, travel companion with a protected and secured personal wallet stored in the cloud and including the rights to travel. The use case will be defined as a specific instantiation of our open concepts, and will benefit from a completely scalable architecture fully instantiated in IP4. This approach is addressing all the key challenges of the work program, supporting a complete door-to- door intermodal travel offer and proposing a seamless integration of the very diverse existing and future services for planning, one-stop-shop ticketing, and real-time re-accommodation. Moreover, thanks to an Interoperability framework which insulates travel applications from the standards fragmentation in multimodal transport, IT²RAIL liberates business-model innovations in the market-place, guaranteeing the economic self-sustainability of these e-services in the long-term.

Keywords: one stop travel shopping,seamless door to door journey planning,interoperability,semantic web,big data,travel companion,data protection,urban trust scheme,business analytics
INtroDucing axial rEsolution in oPToelectronic implantable devices for tHe brain (IN DEPTH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-09-01
End date: 2023-05-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

IN DEPTH aims at developing the first brain implantable device able to gather simultaneously electrophysiology and optical signals with depth resolution and reduced invasiveness. Neuroscientists and neurosurgeons are indeed still limited in accessing and addressing deep brain structures, while the field would instead greatly benefit of low-invasiveness probes monitoring bio-electronic and optical signals with spatial resolution, for both neuroscience and neurosurgery applications. IN DEPTH will answer to the stakeholders needs with a close-to-market fully-integrated device based on minimally invasive tapered optical fibers (TFs) for multipoint light collection and electrophysiology. The system aims at novel applications in both neuroscience research and neurosurgery, with particular reference to cerebral disfunctions including Parkinson’s disease, schizophrenia, or epilepsy, and to fluorescence-guided resection of brain tumors, giving neurosurgeons the possibility to check also the tumor depth and monitor electrical activity during surgery. These aims will be achieved by implementing innovative and high-throughput fabrication process developed for non-planar surfaces, aiming at full compatibility with bench-top equipment for electrophysiology, optophysiology and neurosurgery.

Keywords: photonic implantable devices,optoelectronic implantable devices,optical neural interfaces