Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TAckling Multiple forms of Malnutrition In Ethiopia amongst women of reproductive age and children under five (TAMMIE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 300441.6
EU funding (EUR): 300441.6
Participants: 3
Project status: SIGNED

Increasing evidence shows that undernutrition and overweight/obesity co-exist, affecting countries, households, and individuals. This phenomenon has been labelled the ‘double burden of malnutrition’ (DBM). It has been recognised as a public health problem in Sub-Saharan Africa, calling for interventions addressing all forms of malnutrition simultaneously. Despite impressive progress in reducing undernutrition, Ethiopia still has one of the highest rates of undernutrition globally, which coincides with a rising problem of overweight/obesity, particularly in urban areas. Nevertheless, funding for interventions remains focused on undernutrition. Shifting policies and programmes to address multiple forms of malnutrition requires a good understanding of the problem, the current policy/programme environment and, stakeholders’ views on the nature of the problem and potential ways of addressing it. Unfortunately, such evidence is scarce. Therefore, the TAMMIE project (TAckling Multiple forms of Malnutrition In Ethiopia amongst women of reproductive age and children under five) will assess the DBM to develop a roadmap for action to tackle multiple forms of malnutrition. For this, a 4P cycle (Problem, Policies/Programmes, People, Priority) will be assessed. The exploration of each ‘P’ will constitute a work package, utilising a range of methodologies. The DBM is multifaceted and complex, as such an interdisciplinary approach is fundamental to tackling it. The TAMMIE project is therefore interdisciplinary, drawing on insights from different disciplines (e.g., epidemiology, nutrition, public health, policy science) and methodologies (e.g., systematic review, secondary data analysis of large quantitative datasets, social network analysis, multi-criteria mapping). The gender sensitive approach of this project is key, as women are agents of change and are central to promoting healthy diets and preventing multiple forms of malnutrition for themselves and their offspring.

Keywords: malnutrition,africa,causes,policies,programmes,priorities,ethiopia,women of reproductive age,children,stakeholders,policy makers,mixed methods
Principles of endogenous and therapeutic mRNA turnover in vivo (ViveRNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use of therapeutic mRNAs in medicine. However, lack of knowledge regarding mRNA metabolism in vivo limits the optimization and refinement of such therapies. Our preliminary data, acquired via Direct RNA Sequencing (DRS), shows that variability of poly(A) tail length and, therefore, stability of endogenous and therapeutic mRNAs in different tissues and cell types is much larger than previously thought. Here, we propose the ViveRNA project, which will enhance the DRS (eDRS) pipeline and combine it with analyses of mouse models, primary cell cultures, and synthetic biology approaches to examine the nature of mRNA turnover in vivo and characterize the metabolism of endogenous and administered mRNAs. The goal of the ViveRNA project is to elucidate the complexity of mRNA lifetime regulation. Specifically, our aims are: • Part 1: Construction of an enhanced nanopore Direct RNA Sequencing pipeline (eDRS) for comprehensive analyses of mRNA metabolism. eDRS will assess the composition and lengths of poly(A) tails, modifications, isoforms, and dynamics. • Part 2: Comprehensive analysis of the lifecycle of endogenous mRNAs, analyzing: dynamics, ribosome association, and poly(A) tail metabolism in organs and primary cells and providing insights into the role of particular enzymes. The reach data resource will help designing better mRNA therapeutics and enable the formulation of testable mechanistic hypotheses. • Part 3: Description of the metabolism of therapeutic mRNAs in relevant cell types and tissues. Then, together with the knowledge gained in Part 2, the design of more stable mRNAs with therapeutic potential will be initiated. The ViveRNA project will facilitate the rational design of next-generation mRNA therapeutics.

Keywords: mrna decay,mrna therapeutics,deadenylation,polyadenylation,direct rna sequencing,poly a polymerase,deadenylase
Extreme Particle Acceleration in Shocks: from the laboratory to astrophysics (XPACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1799990.0
EU funding (EUR): 1799990.0
Participants: 1
Project status: SIGNED

Astrophysical shocks are among the most powerful particle accelerators in the Universe. Generated by violent interactions of supersonic, and often relativistic, plasma flows with the ambient medium, shock waves involve a complex and highly nonlinear interplay between the dynamics of flows, magnetic fields, and accelerated particles through mechanisms not yet fully understood. “What is the origin of cosmic rays?”, “What controls particle injection and the acceleration efficiency in collisionless shocks?”, “How is the physics of relativistic shocks modified by electron-positron pair production?”, “Can these mechanisms be studied in the laboratory?” These are long-standing scientific questions, closely tied to extreme plasma physics processes, and where the interplay between micro-instabilities and the global dynamics is critical. Advances in high-power lasers and particle beams are just now opening unique opportunities to probe the microphysics of shocks and particle acceleration in controlled laboratory experiments for the first time. Together with the fast-paced developments in fully-kinetic plasma simulations, computational power, and astronomical observations, the time is ripe to deploy a research program focused on particle acceleration in shocks that can transform our ability to address these questions. In the ERC grant XPACE, we aim to use first-principles massively parallel simulations and laboratory experiments to study the microphysics of non-relativistic and relativistic shocks, and to use data-driven techniques to develop multi-scale models that bridge the gap between the microphysics and the global dynamics. This project will build comprehensive models of the plasma processes that shape magnetic field amplification, particle acceleration, and radiation emission in shocks, with the goal of solving central questions in extreme plasma phenomena, opening new avenues between theory, computation, laboratory experiments, and astrophysical observations.

Keywords: plasma physics particle acceleration in shocks physics of collisionless shocks magnetic field amplification plasma micro instabilities laboratory astrophysics high power lasers particle in cell high performance computing machine learning
Reducing natural gas needs and carbon emissions in industrial usage and transforming industry towards hydrogen with HERC, a novel plasma-assisted combustion (PAC) technology (herc accelerating industrial co2 neutrality)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 3566560.0
EU funding (EUR): 2496592.0
Participants: 1
Project status: SIGNED

Efenco is developing disruptive plasma-assisted carbon-neutral combustion (PA CNC) technology for industrial heat production to achieve a whole new level of efficiency & GHG emissions reduction in the burning of methane, hydrogen & their mixtures. We address the gains & pains of >1MW high-temperature process heat (HTPH) companies on their path to CO2 neutrality. We introduce HERC (High Energy Ray Ceramic), disruptive innovation in fundamental physics & materials technology. HERC chip is a robust, reliable, & self-powered device that initiates PA CNC in the combustion & exhaust processes. HERC boosts burning efficiency by 18% & lowers GHG emissions by 20%. HERC is designed to be fitted in existing industrial boiler systems to gain a higher return on assets & lower OPEX. We estimate that there are around 50,000 suitable systems in the EU only, with the potential to reduce CO2 emissions by 1 Mt a while opening a strong business opportunity of €105.6M in revenue by the end of 2027.

Keywords: industrial combustion,energy intensive industries,energy efficiency,nanoelectronics,micro opto electromechanical systems moems,energy management,district heating,natural gas,plasma assisted combustion pac,low emission natural gas combustion,methane,hydrogen,quantum plasma physics
Interspecies politics in Himalayan borderlands from the mid-nineteenth century to the present (INTERSPECBORD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Climate change, escalating geopolitical tensions, and domestic civil unrest have multiplied the claims made on Himalayan territories cohabited by animals and humans in the name of security, conservation, and development. Hence, the study of human-animal conflicts has become a major area of focus for International Non-Governmental Organizations (INGOs) like the World Wildlife Fund for Nature (WWF). Despite their efforts, scholars point out that current approaches by INGOs discount the interconnected nature of historical, cultural, and political dimensions of human-animal interactions, which limits their ability to create sustainable and just solutions to the ongoing processes of political, ecological, and economic transitions for indigenous communities and their non-human cohabitants, both in the Himalaya, as well as across the globe. INTERSPECBORD examines how interspecies politics historically shape the mobility and identities of human and animal bodies in South Asian Himalayan borderlands from the colonial period in the mid-nineteenth century to the present. Rather than approaching this subject from the perspective of the ‘global south’ or ‘global north,’ this project will emphasise the role of circulation and the ways that different assemblages of ideas, technologies, people, and animals move across space and how historical encounters between these assemblages both shape and are shaped by Himalayan borderland places and ecologies. Against this historical background, this project will investigate how human and non-human species co-produce new bordering practices, which includes hybrid identities, practices of social differentiation, and novel ways of establishing control over borderland spaces. Methodologically, INTERSPECBORD is an interdisciplinary project combining historical research inspired by postcolonial approaches with multispecies ethnography.

Keywords: postocolonial studies animal studies himalayan studies critical border studies
AI Organoid Image Analysis (AIOIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Organoids are microscopically small patient-derived 3D organs that can be cultivated in the laboratory over months mimicking human organs and their functions in vitro. These mini-organs have a human genetic background, maintain disease traits in vitro and are currently available for almost every human organ. Due to these advantages, organoid research and its commercial applications are rapidly evolving and increasingly used. Given the high variability of these complex 3D structures, classical cell culture-based image quantification tools techniques do not accurately capture organoids in microscope images. This has resulted in much image quantification at our laboratory - like in many others - being performed using manual time-consuming tools with a high researcher variability. In sum, there is a global challenge to in a standardized manner quantify organoid experiments. We propose the first Software as a Service (SaaS) toolbox explicitly tailored to organoid imaging, building upon powerful AI-based algorithms for cutting-edge image quantification and independent of the underlying microscope and culture system hardware. The SaaS seamlessly fits in the analysis workflow by offering a user-friendly approach to upload brightfield and immunofluorescence microscope images and videos of organoid cultures, which - at the core of our product - are automatically quantified by AI-models generating a range of organoid metrics. Overall, the provided automation drastically reduces analysis time, promotes accurate phenotypical organoid analyses and ensures standardization of results between different researchers, culture conditions, and imaging hardware. Integrated in an easy-to-use web app, the SaaS tool is of great interest and essential for researchers working in the emerging field of organoids, as shown by the high utilization in our laboratory and the high interest from external partner institutions.
Printable Hybrid Micro-Supercapacitor Based on 2-D Inks using Graphene, TMDs and M-Xenes (PHyS-2D-GraM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Recent tremendous advances in portable and wearable electronics demand lean, lightweight, and flexible future energy storage devices. Printable Hybrid Micro-Supercapacitor Based on 2-D Inks using Graphene, TMDs and M-Xenes, PHyS-2D-GraM is mainly focused on printable flexible and portable energy storage devices based on Two-dimensional (2D) materials and their nanocomposites. The attraction of PHyS-2D-GraM relies on the excellent electrical conductivity, large-scale and low-cost production capability as well as environmental benignity properties of the hybrid 2D materials that will facilitate me to achieve micro supercapacitors with high power and energy densities which will be a great success of the action for the replacement of batteries used in smart garments. The main objective is to demonstrate and fabricate flexible-printable micro-supercapacitors from hybrid 2D nanocomposites designs of vertically stacked current collectors, electrodes, and electrolytes aimed at higher Specific energy (>10 Wh kg-1) by controlled multiple pass printing with porous microstructure in interface layers. The growth of the energy storage market will be mainly driven by the demand for smart, connected, energy-efficient, flexible devices along with the advantage of significantly low-cost methods of manufacture involved in printed devices. To highlight, research studies are very limited in realizing hybrid MXene-TMD-Graphene inks for flexible micro-supercapacitor which has kindled significant interest and foundation for the PHyS-2D-GraM. All the key components of micro supercapacitors, namely, electrodes, electrolytes, and current collectors, can be fabricated by Inkjet Printing through proper formulation and deposition of 2D hybrid inks. The broad range of experimental skills and the successful collaborations that I established with other world leading groups put me in an excellent position to deliver this timely, high impact research in the action.

Keywords: energy storage devices,flexible devices,nano energy,printing energy,micro supercapacitor,
Positive Geometry in Particle Physics and Cosmology (UNIVERSE PLUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Netherlands,United States
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-06-01
End date: 2030-05-31
Duration (months): 72.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 3
Project status: SIGNED

There are strong indications from physics at both infinitesimal and cosmic distances that our current understanding of the laws of nature is only approximate, and must be replaced by deeper principles. The UNIVERSE+ project seeks a new foundation for fundamental physics, ranging from elementary particles to the Big Bang, revealing a hidden world of ideas beyond quantum mechanics and spacetime. Novel geometric objects recently discovered in theoretical physics hint at new mathematical structures. Combinatorics, algebra and geometry have been connected to particle physics and cosmology in an entirely unexpected way. Leveraging these advances, we will launch the field of Positive Geometry, as a new mathematical framework for describing the laws of physics. To this end, we bring together the necessary expertise in particle physics (Arkani-Hamed, Henn), cosmology (Baumann) and mathematics (Sturmfels). This is the first collaboration of its kind, made possible by a recent confluence of critical insights in both mathematics and physics, which are now so closely aligned as to propel us forward on a clear trajectory. Our goals are fiercely ambitious: we aim to create a new mathematical language for describing physical phenomena at all scales, from the interactions of elementary particles to the large-scale structure of the universe.

Keywords: scattering amplitudes,primordial cosmology,quantum field theory,feynman integrals,computational algebraic geometry,positive grassmannian
Reconstructing the origin and functional diversification of eukaryotic heterochromatin (HETERO-EVO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Chromatin functionally organizes all eukaryotic genomes. Genomic regions within heterochromatin are transcriptionally repressed and aberrant expression can be lethal. Heterochromatin is characterized by specific histone modifications, but reader-repressor proteins are directly responsible for preventing DNA-templated processes. Recent studies suggest immense functional diversity of reader-repressor proteins that remains poorly understood. Understanding this diversity will reveal the ancestral composition and capabilities of eukaryotic heterochromatin and uncover unique heterochromatic systems. While exploring heterochromatin in species across the eukaryotic tree of life is key, most lineages have not been investigated due to complications with chromatin isolation, culturing, and genetic manipulation. To address these fundamental biological questions and overcome technical barriers, I will use a recently developed mass spectrometry method to identify proteins associated with known heterochromatic modifications in 19 species cultured in the Sebé-Pedrós laboratory representing all major and several early-branching eukaryotic lineages. To overcome genetic manipulation limitations, I will create a synthetic platform to heterologously assess reader-repressor functions of proteins in budding yeast. I will use this system to functionally characterize new regulators of heterochromatin from diverse eukaryotes. Finally, I will integrate these and other genomic data in a comparative framework to reconstruct the ancestral composition and evolutionary diversification of eukaryotic heterochromatin. Overall, my project will comprehensively identify the functional conservation and diversity of eukaryotic heterochromatin and create a powerful genetic tool to further explore chromatin function and evolution.

Keywords: chromatin,evolution