Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Energy savings in residential buildings using a modular platform to control an all-in-one unit for water heating, climate control, and ventilation (SmartCOMBI)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

To improve energy efficiency, modern “zero-energy” homes are highly insulated. As a consequence homes can no longer ventilate resulting in poor indoor air quality. Thus, the use of efficient ventilation is becoming increasingly important. But ventilation causes significant heat loss, reducing the energy-efficiency of the building. Although advances in last years, current trends in energy systems for climate control and water heating in residential buildings are still unsustainable and further energy savings are fundamental. Significant energy savings can be achieved by combining: (1) an AHU with a heat exchanger and (2) a heat pump to heat water, in a single unit (COMBI-AHU). To reach the household market, COMBI-AHU systems must be re-engineered. The key is an optimized electronic control system for higher efficiency to allow the unit to generate more heat per m2. LS Control, leveraged by its high expertise in electronics, developed a set of cutting edge algorithms and electronic parts to control a COMBI-AHU, allowing disruptive results in terms of efficiency. SmartCOMBI project will contribute to the EU Energy goals by: improving the energy efficiency (COP increase by 25-35%); decrease the energy wastage (>95% of energy recovered); Decrease the GHG emissions. The SmartCOMBI project aims to optimize and demonstrate a novel and cost-effective control platform, resulting in cost savings and benefits for end-users (lower running and installation costs, optimized comfort and healthier environment; better control of expenses – web user interface) and manufacturers (faster route to market and lower customization cost; certification and high energy labels; gain competitive advantage by offering high efficient and cutting edge technology, otherwise impossible due to lack of know-how or financial capacity). The development and market uptake of the AHU Control 2020 will put LS Control as leading technology suppliers and developers for COMBI-AHU solutions for households.

Keywords: all in one energy solution,control algorithms,cost effective solution,electronics,energy saving,heating,modular platform,residentialbuildings,ventilation,zero energy houses
Designing Conjugated Polymers for Photocatalysis and Ion Transport (CAPaCITy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2024-01-31
Duration (months): 76.0
Total project cost (EUR): 2351550.0
EU funding (EUR): 2351550.0
Participants: 1
Project status: SIGNED

Solar energy conversion will play an essential role in the future supply of clean energy. Secure access to energy sources will require energy conversion technologies that are low impact, distributed and accessible both technically and financially. Molecular electronic materials embody these possibilities, offering facile synthesis, low energy production and the versatility to allow performance to be maximized for specific applications. Moreover, they bring appealing similarities with nature’s intrinsically low impact energy conversion materials. Whilst molecular semiconductors have been studied in detail for solar-to-electric energy conversion they have seldom been studied for solar-to-chemical conversion or for charge storage. However, they bring exciting potential advantages in terms of their light harvesting properties, the range of microstructures possible and the ability to tune their electrical properties. Polymer materials applied to solar chemical generation could open up an innovative route to artificial fuels, with the option to control light harvesting and charge separation through structural control. Polymer materials applied to mixed (electronic / ionic) conduction provide a route to lower cost electrochemical storage, as well as to biocompatible devices and sensors. Stimulated by recent experimental breakthroughs in the application of polymers as photocatalysts and ion transport media I will exploit my expertise in multi-scale modelling and functional characterization of molecular electronic materials and devices to develop a design framework for energy conversion and storage in conjugated polymer materials. This proposal aims to disentangle the parameters that govern the performance of conjugated polymer based photocatalysts and ion transport media to discover the underlying functional mechanisms. The tools generated will serve to enable the design and development of high performance materials for energy conversion devices.

Keywords: materials modelling,energy conversion,solar energy
Bio2Skin, a novel biomaterial for medical skin adhesives (Bio2Skin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bio2Skin is a revolutionary new generation of medical-grade adhesives with a wide range of uses in the application of medical devices and wound dressings. This disruptive and unique adhesive will provide a welcome alternative to the current glues used in the application of devices and dressings to the skin which tend to provoke severe skin problems. Currently available adhesives are viscous materials made of synthetic chemicals that fill the skin irregularities, to augment the contact area. When peeled off, they provoke dermatitis, which is caused by the removal of a large amount of epidermis cells. Bio2Skin allows the development of a line of products that can provide effective protection against Medical Adhesive-Related Skin Injury (MARSI). Bio2Skin is based on our unique research on glue-less naturally occurring chemicals results in adhesion to surfaces materially different. Our novel material results from the combination of highly biocompatible chemically-modified polymers that display excellent adhesion properties equivalent or better to current chemical glue-based adhesives. As our product is based with nature in mind, Bio2Skin binds to the natural features of skin offering good adhesion properties without damaging the skin either during use or upon removal, reducing or even eliminating the skin damage caused by the continuous use of current adhesives. Small-scale pre-clinical tests at the Centre for Nanotechnology and Smart Materials (CeNTI Portugal) so far have been extremely promising, and we believe we can make a significant impact in the medical adhesive market which is projected to reach €10 billion by 2019.

Keywords: adhesive,skin,skin injuries,dressings,wounds,wound,wound care,injury,dermatology,clinical,medical,adhesive related skin injury marsi
A developmental engram for the organization of adult hippocampal circuits (NeuroPioneers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 1996947.0
EU funding (EUR): 1996947.0
Participants: 1
Project status: CLOSED

Most adult cortical dynamics are dominated by a minority of highly active neurons distributed within a silent neuronal mass. If cortical spikes are sparse, spiking of single distinct neurons can impact on network dynamics and drive an animal’s behavior. It is thus essential to understand whether this active and powerful minority is predetermined and if true to uncover the rules by which it is set during development. I hypothesize that birthdate is a critical determinant of neuronal network function into adulthood. More specifically, I reason that neurons that are born the earliest are primed to participate into adult network dynamics. The goal of this proposal is to challenge this original hypothesis, which is considerably fed by our past work aiming at understanding how cortical networks function and assemble during development. Hence, we have shown that an early birthdate: (1) specifies the specialization of GABA neurons with a hub function, that orchestrate perinatal network dynamics in the mouse hippocampus (Bonifazi et al. 2009) and develop into long-range projecting GABA neurons into adulthood (Picardo et al. 2011); (2) delineates a subtype of CA3 glutamate neuron with a “pacemaker” function in the absence of fast GABAergic transmission (Marissal et al. 2012). We will analyze the structure and function of early born GABA and glutamate neurons, in the adult mouse hippocampus, mainly in vivo, where the extensive and long-range connectivity of these cells is preserved. To this aim, we have translated from the in vitro to the in vivo situation, our multidisciplinary method to investigate structure-dynamics relationship in cortical networks. Using this approach, we have recently shown that, in the absence of external landmarks, distance is encoded within the hippocampus in recurrent and self-circumscribed sequences of neuronal activation. Our proposal will specifically examine the recruitment of early born neurons in this sparse network dynamics pattern.

Keywords: gaba imaging hippocampus networks hub spatial representation place cells
Screening for monoclonal gammopathy of undetermined significance: A population-based randomized clinical trial (MGUS screening RCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Iceland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1474304.0
EU funding (EUR): 1474304.0
Participants: 1
Project status: CLOSED

Monoclonal gammopathy of undetermined significance (MGUS) is a very common precursor condition to multiple myeloma (MM), and related diseases, and can be found in approximately 4-5% of individuals over the age of 50 years. MM is always preceded by MGUS. Current risk stratification schemes, designed to predict those that will progress, are based on retrospective data and rely almost solely on serum protein markers. While they can differentiate high and low-risk patients, they cannot predict outcome for individual patients, are not integrated with one another, and have limited biological correlation. Based on retrospective data, it is recommended that individuals with MGUS are followed indefinitely; however no prospective study has ever been performed to evaluate this or identify optimal monitoring in MGUS individuals. We recently showed that MM patients with a prior knowledge of MGUS had superior survival compared to MM patients without, which raises the question whether routine screening for MGUS in the population might improve survival. To evaluate the impact of screening for MGUS on overall survival, to provide evidence for the optimal MGUS follow-up, and to integrate biological, imaging, and germline genetic markers in evaluating individual risk of progression, we propose to invite all individuals >50 years in Iceland (N=104,000) to participate in a screening study for MGUS. This will be done by utilizing already present infrastructure for screening in Iceland and the fact that most individuals >50 years have their blood drawn for various reasons during 3 years. We plan to perform electrophoresis and free light chain analyses in these individuals to diagnose MGUS. Individuals with MGUS will be invited to be included in a randomized clinical trial with 3 different arms to identify the optimal work-up and follow-up strategy and to build a new risk model for progression. Our large, unique, population-based study has major clinical and scientific implications.

Keywords: monoclonal gammopathy of undetermined significance mgus,multiple myeloma,screening,randomized clinical trial
Combinatorics in Transcendental Dynamics (CoTraDy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Complex dynamics studies the evolution of a complex manifold under the action of a holomorphic map. In this proposal we study the dynamical systems generated by transcendental (either entire or meromorphic) maps acting on the complex plane. By using a wide range of classic and new techniques, we investigates epecially the combinatorics of these maps: that is to say, we build relations between the dynamics of the transcendental map on some specific subset of the complex plane and the dynamics of the shift map on the space of infinite sequences over the integers. Combinatorics in this setting is a powerful tool to understand the dynamics of transcendental maps and to understand the structure of specific families of transcendental maps. The study of combinatorics for transcendental maps is also likely to offer new insights in the combinatorics for rational maps and possibly in other areas of complex dynamical systems, like the systems generated by the iteration of holomorphic maps on manifolds with more than one complex dimension.

Keywords: one dimensional complex dynamical systems,holomorphic dynamics,mlc conjecture,transcendental dynamics,rigidity
Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling (ChromatinRemodelling)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1498954.0
EU funding (EUR): 1498954.0
Participants: 1
Project status: CLOSED

The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure and their aberrant regulation or dysfunction has been implicated in various cancers and severe developmental disorders. A better understanding of the roles of chromatin-interacting complexes in such disease states requires a detailed mechanistic study. Many chromatin-interacting complexes modify chromatin structure, yet understanding the underlying mechanisms remains a major challenge in the field. Furthermore, how chromatin-interacting complexes are regulated to enable their various functions is incompletely understood. We will address these longstanding questions in two specific aims. Aim I: Building on our expertise in single-molecule biology, we will develop powerful single-molecule imaging approaches to monitor the action of chromatin-interacting complexes in real time. We will further probe how the diverse activities of the chromatin-associated complexes are coordinated and coupled to conformational transitions. Aim II: Drawing on our expertise in structural biology, we will use a range of structural techniques in combination with biochemical approaches to study the vital regulation of chromatin-interacting complexes by their regulatory subunits as well as by chromatin features. We expect to obtain ground-breaking insights into the mechanisms and regulation of disease-related chromatin-associated complexes, which may open up new horizons for developing therapeutic intervention strategies. Furthermore, the approaches developed here will enable the investigation of a large number of chromatin-related processes.

Keywords: chromatin,chromatin remodelling,molecular motors,motor mechanisms,allosteric regulation,nucleosome
Developing and implementing the Next European Photonics21 industrial PPP Strategy (NextPho21)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Partnership: Photonics (cPPP)
Countries involved: Austria,Italy,Spain,Ireland,Italy,Germany,Switzerland,Finland,Greece,Sweden,Poland,Poland,France,Netherlands,United Kingdom
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 2997400.0
EU funding (EUR): 2997400.0
Participants: 17
Project status: CLOSED

NextPho21 provides the decisive support to the European Photonics21 community for developing a European industrial strategy for the upcoming 10 years. Strategy development will involve more than 3000 Photonics21 and end-industry experts in an open, transparent and democratic decision-making process. The strategy approach focusses on future market opportunities arising from the megatrends like digitisation, urbanisation, smart anything everywhere which disrupt business models and whole industries. Through developing the joint strategy, the European photonics industry will be in the pole position to become a key driver of this revolution. Furthermore, NextPho21 will set up a management and steering platform for implementing the current Horizon2020 Photonics21 Public Private Partnership strategy. It provides strategic and organizational support to the PPP boards and Horizon2020 Photonics KET (PPP) projects in reaching its objectives, namely to create growth and jobs in Europe. This includes a central public relation and dissemination services to the projects demonstrating the impact of photonics for wider deployment of photonics in end user industry products. NextPho21 implements a dedicated set of actions to increase the investments in photonics research, development and manufacturing by European venture capital funds and the European Investment Bank to bring photonics innovation to the market. It will trigger cross regional and cross member state strategy development and investments in photonics respectively by providing a coordination and support platforms to these stakeholder groups. The NextPho21 project consisting of the Photonics21 secretariat and 12 National Technology Platforms - representing more than 25 photonics cluster – runs at the request, with the consent and on behalf of the Photonics21 PPP Boards which will closely steer all activities of the project.

Keywords: photonics21,strategy
European Holocaust Research Infrastructure Preparatory Phase (EHRI-PP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Israel,Austria,Germany,Italy,Belgium,Poland,Belgium,Romania,Slovakia,France,Czechia,United States,Netherlands,United Kingdom,United Kingdom
Call: Preparatory Phase of new ESFRI projects and early phase support to ESFRI high strategic potential areas (H2020-INFRADEV-2019-2, 2019)
Start date: 2019-12-01
End date: 2023-05-31
Duration (months): 42.0
Total project cost (EUR): 3989023.75
EU funding (EUR): 3989023.25
Participants: 15
Project status: SIGNED

The Preparatory Phase project of the European Holocaust Research Infrastructure (EHRI) is an outcome of EHRI’s adoption on the 2018 Roadmap of the European Strategy Forum on Research Infrastructures (ESFRI). The EHRI-PP project aims to bring EHRI to the level of financial, legal and technical maturity required for its implementation as a permanent European RI in the domain of Holocaust studies and archives. In particular, the project will ensure the long-term sustainability of EHRI through the drafting of a sound business plan that links EHRI’s scientific case, user and access policy and value proposition to a robust governance structure, legal framework and a financial plan. It will further ensure EHRI’s timely implementation by developing a detailed implementation plan and by negotiating firm financial commitments from national stakeholders. The EHRI-PP project will be carried out by a consortium of 15 partners from 13 countries that have jointly developed EHRI in the context of two EU-funded Integrating Activities since 2010. The consortium includes the major Holocaust RIs in Europe, Israel and the United States. EHRI’s scientific mission is to overcome the enormous fragmentation of Holocaust archives and research. It approaches this mission through the development of a pan-European distributed RI that offers virtual and trans-national access to source material, and promotes the exchange of resources, knowledge and expertise across disciplinary and geographic boundaries. EHRI also plays an important societal role. It ensures that Holocaust commemoration is based on sound scientific research and informed by authoritative archival sources. EHRI thereby contributes to the development of open and non-discriminatory societies across Europe. By consolidating EHRI’s previous achievements and results into a new, sustainable, distributed RI, EHRI-PP will secure Europe’s place at the forefront of Holocaust documentation and research for the long-term.