Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrogen Plasma Reduction for Steelmaking and Circular Economy (H2PlasmaRed)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Finland,Austria,Germany,Belgium,Sweden,France
Call: Low carbon-dioxide emission technologies for melting iron-bearing feed materials OR smart carbon usage and improved energy & resource efficiency via process integration (Clean Steel Partnership) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6374937.5
EU funding (EUR): 5997965.0
Participants: 15
Project status: SIGNED

The main objective of H2PlasmaRed is to develop hydrogen plasma smelting reduction (HPSR) technology for the reduction of iron ores and steelmaking sidestreams to meet the targets of the European Green Deal for reducing CO2 emissions and supporting the circular economy in the steel industry across Europe. Our ambition is to introduce a near CO2-free reduction process to support the goal of the Paris Agreement - a 90% reduction in the carbon intensity of steel production by 2050. To achieve this, H2PlasmaRed will develop HPSR from TRL5 to TRL7 by demonstrating the HPSR in a pilot-HPSR reactor (hundred-kilogram-scale) that is an integrated part of a steel plant, and in a pilot-scale DC electric arc furnace (5-ton scale) by retrofitting the existing furnace. The project's end goal is to establish a way to upscale the process from pilot-scale into industrial practice. To support this goal, the novel sensors and models developed and implemented in the project are used for HPSR process optimization from a reduction, resource, and energy efficiency standpoint.

Keywords: steelmaking,hydrogen plasma smelting reduction hpsr,iron ore,steelmaking sidestreams,co2 mitigation,circular economy,process control and optimization
Phase-resolved THz-Higgs Spectroscopy on Superconductors (T-Higgs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2292750.0
EU funding (EUR): 2292750.0
Participants: 1
Project status: SIGNED

T-Higgs develops “Higgs Spectroscopy” as novel tool to probe the order parameter in superconductors. It will allow unprecedented insights into the structure and dynamics of the condensate and shine new light onto the physics of unconventional superconductors. In particular high temperature superconductivity calls for new probes to reveal its pairing mechanism. T-Higgs can also be applied to intriguing phenomena like light- induced superconductivity, superconductivity in “twisttronics” or under extreme conditions matching the ongoing importance of superconductivity in quantum materials. T-Higgs is a high-field phase-resolved non-linear THz spectroscopy on order parameter excitations of the superconducting ground state itself, the Higgs oscillations. Probing the internal structure of the condensed Cooper pairs this reveals not only the symmetry of the order parameter but also couplings of the condensate to external modes and their interplay with superconductivity.

Keywords: higgs,thz,superconductivity,ultrafast,time resolved
South Eastern Mediterranean Excellence Development in FIre REsearch (SEMEDFIRE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Cyprus,Netherlands,Spain,France,United Kingdom
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 940455.0
EU funding (EUR): 940454.5
Participants: 6
Project status: SIGNED

In full alignment with the WIDERA-Twinning-topic’s requirements, SEMEDFIRE aims to enhance the capacities and knowledge-acquisition of the Widening institution; EUC, in Research-&-Innovation (R&I) and Research-Management-Administration (RMA) relating to Fire Safety and Fire Management. This is aimed through networking activities with five top-class leading counterparts at EU level; IMPERIAL COLLEGE, WAGENINGEN UNIVERSITY, PAU COSTA FOUNDATION, FRENCH GENERAL DIRECTORATE OF CIVIL SECURITY AND CRISIS MANAGEMENT and NIMES-Metropole, which represent a multifaceted, but complementary and synergistic, ‘geography’ of R&I-philosophies and approaches, comprising: •two leading Academic institutes in the area of fire safety and integrated fire management; •a leading Foundation in investigating fires and communities-engagement; •a Governmental Agency leading the EU-effort in operationally combating Forest Fires; •an Agglomeration of Municipalities providing the tangible example of local governance in Forest Fires; •a representation of both Member States and an Associated Country; •a linking of the European Research Area (ERA) in a “compass” fashion: from north (UK) to central Europe (FR, NL), to the west (ES), and to the Mediterranean biogeographical region (ES, FR, CY) and its South-Eastern area (CY). The networking-for-excellence and twinning-contributions of the internationally-leading Advanced Partners in knowledge-transfer and capacity-building, focus on both EUC and within and for its surrounding targeted stakeholders from public governance, industry/ entrepreneurship and civic society, at local and regional levels. It is hence scoped to raise the profile and reputation of EUC to such a level of ERA-excellence that it will be able to become a lighthouse of spreading fire-science excellence in Cyprus and the SE Mediterranean, as well as to nurture a culture of societal fire-safety.

Keywords: fire safety management,networking,community engagement,fire modelling,interagency exchange
A function for sleep-dependent tau dynamics (sleepyTau)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Dysfunction of protein Tau is the main cause of dementia. Dementia associates with synaptic failure and sleep disturbances, but their connection remains elusive. In dementia, Tau becomes hyperphosphorylated (p-Tau) causing synaptic loss. Temperature fluctuations also associate with Tau phosphorylation, for example in hibernating animals. Intriguingly, my work demonstrates that brain temperature decreases during sleep, and further evidence suggests there are Tau-sites phosphorylated during sleep. My hypothesis is that sleep (and temperature)-induced Tau phosphorylation drives synaptic plasticity changes during sleep. To investigate this, I will map the dynamic changes in p-Tau during sleep and then delve into the mechanisms by mimicking brain temperature changes that naturally occur during sleep in human-induced neurons and mouse primary neurons. Employing genome engineering, I will interfere with p-Tau during sleep in mice in vivo and evaluate its impact on sleep, sleep-dependent synaptic plasticity and hippocampal long-term potentiation. This research challenges the notion that p-Tau solely drives disease progression, exploring a physiological function for p-Tau in regulating synaptic plasticity during sleep. The result of this project can challenge our understanding of Tau's function and open a new therapeutic avenue: the development of sleep-wake mechanisms to reverse the pathological p-Tau state observed in dementia. With my host lab's prior track record of uncovering critical insights into Tau-induced synaptic dysfunction, it stands as the perfect platform to tackle these questions. Additionally, I find myself in an ideal position, armed with exciting preliminary data that bolsters the validity of this proposal, and a robust technical and scientific background that empowers me to embark on this ambitious research journey. The plan I propose brings us closer to breakthroughs in effective dementia treatments.

Keywords: temperature,sleep,tau,phosphorylation
IoT Supported Electronic Geotextiles for Sustainable and Smart Precision Agriculture (I-TEXGEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,Greece,France,Romania,Tunisia,Slovenia,North Macedonia
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 1910957.14
EU funding (EUR): 1683360.0
Participants: 13
Project status: SIGNED

This project aims to develop an innovative IoT-supported geotextile-based sensor network and control system capable of monitoring key soil parameters such as moisture, temperature, nutrients (N, P, K), and pH level with the goal of enhancing precision agriculture, soil health and sustainable crop growth. The system, designed with a biodegradable, carbon-impregnated geotextile structure, will reduce the need for excessive fertilizers, pesticides and water while facilitating and improving nutrient retention, plant root respiration, soil health and crop yields. The first phase will focus on the development of a novel intelligent IoT supported geotextile multi-sensor network and control system (i-TexGeo), which will possess advanced sensing capabilities for comprehensive soil monitoring. In the second phase, the soil field studies covering implementation of i-TexGeo system will be realized across a diverse range of geographical areas, including Europe, Tunisia, and Turkey on a laboratory scale within the soil field laboratories of Agricultural Institutes and real-world agricultural environments with farmers. It focuses on the continuous monitoring and tracking of soil parameters, integrating interdisciplinary efforts across textiles, electronics, information technology, communication systems and agricultural sciences. By fostering collaboration among these fields, the project seeks to enhance precision agriculture through real-time data collection and analysis, ultimately promoting sustainable farming practices improving soil health and crop management. Through the integration of innovative geotextile based sensor technology together with IoT, the project will foster the development of a sustainable solution for modern smart precision agriculture, benefiting various segments of society, including farmers, agricultural communities, scientists, policymakers and consumers at large.
Space-time quantum metasurfaces with two-dimensional layered materials (QuMeta)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Hong Kong
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 3
Project status: CLOSED

Many disruptive information technologies (such as quantum technologies and 6G communication) have been emerging as critical enablers to significantly promote human wellbeing, such as ultra-fast computers and mobile Internet. However, due to civilized development and growing volumes of data, it has aroused higher requirements of data-processing power and wireless communication efficiency. Exploring new approaches to improve the performance in advanced information technology is a destination that scientists have been constantly pursuing. One promising technology for achieving such goals in a spatially and temporally controllable manner utilizes an artificially engineered array of active elements, known as space-time metasurfaces. This project will use one of two-dimensional (2D) materials (graphene) to design and fabricate space-time metasurface, addressing a key question in the fields of quantum information and photonics: how to dynamically manipulate the quantum states of entangled photons or nonlinear light based on different degree of freedom, such as frequency and polarization. The key objective of the project is to build a practical prototype of space-time quantum metasurfaces based on graphene for the first time. This project will focus on three different objectives: theoretical design of time-modulated algorithm and optimized space distribution, fabrication of space-time metasurfaces with gated-tuned graphene nanopatterns, and quantum imaging applications of space-time metasurfaces. The multidisciplinary nature of the project is strong, involving a combination of well developed optics, information science, quantum technology, 2D materials and nanofabrication. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. Results have the potential capacity to increase the competitiveness of quantum technology and nanophotonics.

Keywords: nanophotonics,quantum information technology,optical metasurfaces,time modulated array
Negative Regulation of Inflammatory Responses Revealed with Camelid Nanobodies (DEFLAMMATION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1997828.0
EU funding (EUR): 1997828.0
Participants: 1
Project status: SIGNED

The innate immune system evokes inflammation to control pathogens or damage. Sophisticated mechanisms interpret molecular triggers to activate inflammasomes or transcription of pro-inflammatory genes. While numerous autoinflammatory conditions underline the need to control inflammation, we still rely on simplistic models to understand its negative regulation. I hypothesize that an intricate signaling network interprets information to prevent or downregulate inflammation. Understanding these so far elusive processes demands radically new cell biology tools, which I will develop and apply in ‘DEFLAMMATION’. I propose to define signaling hubs that integrate cellular input and coordinate effectors to actively downregulate inflammation where beneficial to the organism. To yield unprecedented molecular insights, we will apply nanobodies to inhibit protein function, manipulate post-translation modifications, and visualize endogenous proteins and their binary interactions. I hypothesize that two poorly understood members of the NLR family, NLRC3 and NLRX1, act as signaling hubs that coordinate negative regulation of pro-inflammatory gene expression. No such coordinator is known for inflammasomes. In objective 1, we will pinpoint how NLRC3 controls inflammation and T cell activity. I hypothesize that NLRC3 forms anti-inflammatory signalosomes to control the ubiquitination status of pro-inflammatory signaling components. In objective 2, we will reveal how NLRX1 counteracts interferon responses, inflammation, and proliferation. We will explore whether NLRX1 activation coordinates organelle-specific autophagy to remove pro-inflammatory signaling complexes. In objective 3, we will identify novel regulatory circuits that control inflammasome activation using CRISPR/Cas9 and cDNA screens, taking advantage of a novel reporter we have developed. The anticipated results will reveal entirely new layers of regulation of inflammation with implications for therapeutic interventio

Keywords: inflammation,signaling,ubiquitination,autophagy,nanobodies
Versatile Amplification Method for Single-Molecule Detection in Liquid Biopsy (VerSiLiB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland,Italy,Austria,Czechia
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2026-03-31
Duration (months): 48.0
Total project cost (EUR): 2994244.99
EU funding (EUR): 2994244.99
Participants: 7
Project status: SIGNED

Robust detection of single molecules in complex biological fluids is the ultimate goal in the field of disease biomarker analysis. Conventionally, to enable the quantitative analysis of individual molecules in macroscopic volumes, analyte pre-concentration and sample partitioning into fL-nL compartments has been combined with the amplification of the specific recognition events. In these setups, the positive or negative detection of fluorescence signal is triggered by enzymatic reactions occurring in each compartment. Binary readout based on Poisson statistics quantifies ultra-low concentrations of analyte molecules. This approach has been adopted for nucleic acids analysis in current digital PCR, and is also available for proteins in a technique coined as digital ELISA. The objective of VerSiLiB is to develop an enzyme-free amplification strategy for the analysis of both protein and nucleic acid analytes with the single digital platform that offers means to access additional information on target analytes not achievable with current technologies. Method is based on novel affinity-mediated-transport amplification, where affinity interaction of target analyte with a specific ligand attached to a magnetic nanoparticle transporter is accompanied with rapid shuttling of fluorescent tracers that serve as reporters. By applying external magnetic field, tracers are transported from the tracer storage side (where they are dark) to tracer active side (where they become bright) only if target analyte is present in the small reaction compartment. Tailored plasmonic nanostructures will be prepared at the storage and active sides of the compartment to render the tracer either dark or bright. The aim is to perform technology validation for the novel VerSiLiB proteogenomics amplification platform in cancer management using biobanked liquid biopsy samples.

Keywords: biosensor,liquid biopsy,molecular amplification,single molecule detection,cancer management,antibody engineering,microfluidics
Hybrid nanostructured systems for sustainable energy storage (HYNANOSTORE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1973133.75
EU funding (EUR): 1973133.75
Participants: 1
Project status: SIGNED

Humanity will increasingly need safe, clean and always available energy. Thus, having good energy storage systems will be more and more important in the future. Efficient and sustainable rechargeable batteries are required to power portable electronic devices, new hybrid electric vehicles and to store electricity from renewable sources. The mission of HYNANOSTORE is the development of new environment-friendly systems based on that organic molecules which are used in the chemistry of life for the storage of chemical energy and its transformation in electrical energy. HYNANOSTORE re-thinks the concept of battery’s electrode based on lithium insertion and propose a novel architecture in which the redox properties of bio-molecules such as enzymatic co-factors can take up and release ions reversibly in order to overcome the problems (safety, sustainability and long-term ciclability) associated with the use of conventional Li ion batteries. To achieve this, a nanostructured conductive scaffold with tailored characteristics will provide a framework to immobilize redox active molecules, extended surface area to maximize their loading, a pathway for the charge transport and a diffuse interface for the interaction with the electrolyte. The new bio-inspired engineered system developed after the successful completion of HYNANOSTORE will offer benefits in terms of power and cyclability; an energy density of 500 W h kg-1 and the retention of at least 90% capacity after cycling 800 times are expected with the implementation of these systems. The output of the project HYNANOSTORE will be the introduction of a new concept for lithium ion batteries towards cheap, green and versatile energy storage devices.

Keywords: energy storage,nanomaterials,rechargeable batteries