Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Personalised Living Cell Synthetic Computing Circuit for Sensing and Treating Neurodegenerative Disorders (PRIME)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Ireland,Cyprus,Finland,Denmark
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 4401252.5
EU funding (EUR): 4401252.5
Participants: 8
Project status: SIGNED

There remain urgent and unmet needs for the treatment of neurological diseases. Epilepsy is a serious, chronic brain disease characterized by recurrent seizures. Closed-loop, implanted devices offer ways to reduce seizures in drug-resistant patients but their efficacy is poor and they interrupt seizures only after they begin. PRIME capitalizes on a breakthrough discovery that transfer RNA (tRNA) fragments, a novel class of noncoding RNA, increase in patients in advance of when a seizure occurs. We propose to engineer human cells to respond to tRNA fragment elevations as the trigger for pre-emptive release of glial-derived neurotrophic factor (GDNF), a seizure-suppressing and disease-modifying treatment. Artificial Intelligence (AI) algorithms will be used to integrate OR or AND logic gate functions in the switching process, depending on the quantity and type of tRNA fragments and timing of their release in a given epileptic network and a second, fail-safe calcium-dependent pathway will allow GDNF release in the event of a breakthrough seizure. This enables a precise level of personalization in the design of the bio-computing cells, which will be encapsulated into a membrane device within the microenvironment scaffold, enabling the engineered cells to co-exist with natural brain tissue. Validation of the bio-computing cells will be tested in both in vitro microfluidic organ-on-a-chip as well as in vivo tests for effects on spontaneous seizures in rodents with epilepsy. PRIME’s results will provide a transformational diagnostic-therapeutic treatment for epilepsy and other neurological diseases that feature disrupted neuronal network function.

Keywords: epilepsy,bio computing logic circuit,molecular communication,biomarker,synthetic biology,autonomous implantable cell system,seizure suppression,personalised medicine,neurodegenerative disease
DAFNE: Use of a Decision-Analytic Framework to explore the water-energy-food NExus in complex and trans-boundary water resources systems of fast growing developing countries. (DAFNE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Ethiopia,Germany,Greece,Belgium,Zambia,Switzerland,United Kingdom,Mozambique,Sri Lanka,Kenya,United Kingdom
Call: Development of water supply and sanitation technology, systems and tools, and/or methodologies (H2020-WATER-2015-two-stage, 2015)
Start date: 2016-09-01
End date: 2020-10-31
Duration (months): 50.0
Total project cost (EUR): 5420222.68
EU funding (EUR): 3408658.75
Participants: 14
Project status: CLOSED

Global trends in population growth and rising economic prosperity will increase the demand for energy, food and water, with more severe impact in fast-growing economies, such as in several African countries. The constraints on water, energy, and food could well hamper economic development, lead to social and geopolitical tensions, and cause lasting environmental damage. DAFNE advocates an integrated and adaptive water resources planning and management approach that explicitly addresses the water-energy-food (WEF) nexus from a novel participatory and multidisciplinary perspective. This includes social, economic, and ecologic dimensions, involves both public and private actors and is socially inclusive, enhances resource efficiency and prevents the loss of ecosystem services in regions where large infrastructures exist or are being built and intensive agriculture is expanding. A decision-analytic-framework (DAF) will be developed to quantitatively assess the social, economic, and environmental impact of expanding energy and food production in complex physical and political contexts, where natural and social processes are strongly interconnected and the institutional setting involves multiple stakeholders and decision-makers. The DAFNE approach will be demonstrated by analysing two cross-boundary case studies, the Zambezi and the Omo river basins. The WEF nexus will be quantified and analysed as the trade-off between conflicting objectives such as hydropower production vs irrigation, land exploitation vs conservation, etc. The nexus will be translated in economic values and impact on growth, ecosystems and ecosystem services. DAFNE will allow a better understanding of the WEF nexus, and generate and explore alternative planning and management solutions based on the cooperation of public and private stakeholders, which foster the profitable but equitable use of resources without transgressing environmental limits or creating societal and/or stakeholder conflicts.

Keywords: trans boundary basins,developing countries,integrated water resources management,decision analytic framework,sustainable development,interdisciplinary,participatory and integrated planning
Positive Environment in Public Participation and Engagement for Responsible Research and Innovation (PEPPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Public engagement is one of key components for responsible research and innovation that the European Commission has identified and promoted. However, it has been questioned about legitimating the process and result, contributing to policy decisions and facilitating social learning. It is now also challenged by the recent post-truth movement in terms of democracy, citizenship and sustainability. Positive experiences of active involvement within society can be critical to engage with the silent majority and marginalised majorities, as well as researchers under pressure of public engagement. This research thus examines positive environment in top-down, expert-led public engagement or bottom-up, grassroots activities such as citizen science and open innovation, in which responsibility is distributed to experts, stakeholders and citizens in a more natural and proportional manner. It identifies methodologies to incorporate voices and values of less engaged individuals and future generations into the design and implementation of positive engagement, developing novel approaches to visualise participants’ perceptions and perspectives and/or emerging technologies and their ethical, legal and social aspects. This transdisciplinary research collects and analyses data on individual, community and organisational and societal level through the study of selected cases of positive engagement, with reference to community-based participatory research, intergenerational ethics and organisation and management studies. Introducing a wide variety of Norwegian practices to the European research and policy context, the project will disseminate the research results to the case organisations and their affiliations and networks and finally produce a communication training manual for positive engagement. This fellowship also gives a good opportunity to exchange knowledge on public engagement practiced in Europe and Japan.

Keywords: positive engagement,distributed responsibility,citizen science,open innovation
Social life in the city: how urbanization affects cooperation and competition among social birds (urbanbird)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Urbanisation currently forms one of the most important threats to biodiversity. Urbanization involves a drastic change of the environment, which will require species to adapt. Studies have shown that animals in urban environments differ in their behaviour, morphology and physiology from those in rural environments. However, how these differences come about remains unclear. Individuals might be able to show plasticity in their behavioural response to the new environment. Alternatively, certain types of individuals might be more likely to move to cities, or certain individuals might be more successful there. Despite the attention on how urbanization has affected behavioural changes to the environment, the effect on intra-specific social behaviours has been neglected, despite its importance for fitness. Furthermore, the long-term consequences of urbanization for populations remain unknown. The proposed project aims to investigate the underlying mechanisms of changes in social behaviours and the long-term population consequences. I will use the house sparrow (Passer domesticus) as a model system, which although widespread in both urban and rural environments, has undergone extreme declines, particularly in European cities. Using a citizen science approach, combined with new experiments, the knowledge generated by this project will help predict the effects ongoing urbanization will have on species and biodiversity. During this interdisciplinary project I will exchange knowledge with experts in the field of conservation and applied ecology. The proposed fellowship will allow me to re-enter the European academic system and develop skills required to initiate my own effective research group following the project.

Keywords: birds,survival,social behaviour
Role of Retinoic Acid signaling in cDC1 and cDC2 on intestinal immune homeostasis and disease (Retinoic AC-DC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-04-25
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

For the past years, it has become undeniable that environmental signals have a great impact on the intestinal immune system. Among them, the Vitamin A (Vit A) has a central role in intestinal immunity. Consequently, the Vit A deficiency (VAD) is associated with an increase of infectious diseases and the supplementation of Vit A to pregnant mothers and children is a protocol defined by the World Health Organization. The vit A is mostly absorbed in the small intestine and derived into Retinoic Acid (RA), especially by conventional dendritic cells (cDC). Studies on the impact of RA on intestinal immunity, including in the host laboratory, have highlighted a major impact of RA produced by cDC on the homing and the polarization of effectors cells, although the effect of the RA on specific cDC subsets remains unknown. The understanding of this effect is an essential step for manipulating the system while avoiding secondary effects, usually triggered by impacting such central metabolites as RA. We propose to define this specific action of the RA on cDC using cutting edge technologies and state of art techniques both developed in the laboratory and brought by the candidate. These techniques will allow the investigation of the RA effect on specific intestinal cDC subsets at transcriptomic and phenotypic levels under homeostatic and pathologic states. The host laboratory will develop the professional skills of the candidate by reinforcing his individual competences, including laboratory techniques, writing, critical and innovative thinking, and communication abilities. Those will be further enhanced by the participation to many national and international collaborations enabled by Dr. Agace’s strong network. The high-quality infrastructure provided to the candidate and his complementary profile and techniques, acquired during his PhD, will ensure a solid project development and allow him to acquire all the abilities needed to become an efficient independent researcher.
Advancing the Equation of state of Neutron Stars (AEONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 2425000.0
EU funding (EUR): 2425000.0
Participants: 1
Project status: SIGNED

Densities in neutron star (NS) cores can reach up to ten times the density of a normal atomic nucleus, and the stabilising effect of gravitational confinement permits long-timescale weak interactions. This generates nucleonic matter that is extremely neutron-rich, and the exciting possibility of stable states of strange matter (hyperons or deconfined quarks). Our uncertainty about the nature of cold ultradense matter is encoded in the Equation of State (EOS), which can be mapped via the stellar structure equations to quantities like mass M and radius R that determine the exterior space-time. One very promising technique for measuring the EOS exploits hotspots that form on the NS surface due to the pulsar mechanism, accretion streams, or during thermonuclear explosions in the stellar ocean. As the NS rotates, the hotspot gives rise to a pulsation and relativistic effects encode information about the EOS into the pulse profile. Pulse Profile Modelling (PPM), which employs relativistic ray-tracing and Bayesian inference codes to measure M-R and the EOS, is being pioneered by NASA’s NICER telescope, which is poised to deliver its first results in 2019. Complexities, that have only become apparent with exposure to real data, mean that there is work to be done if we are to have confidence in the nominal 5-10% accuracy of NICER’s M-R results. AEONS will deliver this. The project will also look ahead to the next generation of large-area X-ray timing telescopes, since it is only then that PPM will place tight constraints on dense matter models. The sources these missions target, accreting neutron stars, pose challenges for PPM such as variability, surface pattern uncertainty, and polarimetric signatures. AEONS will develop a robust pipeline for accreting NS PPM and embed it in a multi-messenger EOS inference framework with radio and gravitational wave constraints. This will ensure that PPM delivers major advances in our understanding of the nature of matter.

Keywords: neutron stars,dense matter,bayesian inference,relativistic ray tracing,thermonuclear bursts,burst oscillations,accreting pulsars
ACCENTO (Active Clearence Contol dEsigN and characTerizatiOn). Advanced investigations on different Low Pressure Turbine Active Clearance Control (LPTACC) system by means of CFD and experiments. (ACCENTO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy
Call: Optimizing impingement cooling (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-09-30
Duration (months): 30.0
Total project cost (EUR): 677500.0
EU funding (EUR): 677500.0
Participants: 2
Project status: CLOSED

This proposal refers to the Clean Sky 2 topic JTI-CS2-2018-CfP08-ENG-01-36 “Optimizing impingement cooling”. The objective of ACCENTO (Active Clearence Contol dEsigN and characTerizatiOn) project is to carry out a series of advanced investigations on different Low Pressure Turbine Active Clearance Control (LPTACC) system pipes and target plates. The aim is to develop design/verification procedures and models to confidently predict the impinging system aero-thermal behaviour. This goal will be pursued by means of dedicated experimental tests and numerical simulations. The great ambition of the ACCENTO program is to design a modular test rig able to accommodate long ACC pipes (0.8 m to 1.5 m) which will be operated in engine representative conditions. The rig will be able to provide reliable data for impingement cooling heat transfer characterization in a wide range of operating points. The radiative heat transfer impact on the system performance will be also accounted for. The rig will provide high quality data in conjunction with controlled operating conditions to validate CFD tools for the heat transfer and, more in general, for the ACC system characterization. The expected outcomes of the project are the design, the commissioning and the testing of a modular rig for ACC heat transfer process characterization, the validation of CFD methodologies for such systems analysis and the development of design correlations for both the impingement holes discharge coefficient and for the jets Nusselt number. Moreover, thanks to the modularity of the developed rig, future and successive tests and analyses will be possible.

Keywords: lptacc,impingement,clearance control,heat transfer,cooling,discharge coefficent
Strategic investments in European manufacturing to win global challenges (M-Future2015)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Coordination and support actions
Countries involved: Lithuania,Luxembourg
Call: Presidency events (H2020-NMP-CSA-2014, 2014)
Start date: 2014-12-01
End date: 2016-03-31
Duration (months): 16.0
Total project cost (EUR): 867203.75
EU funding (EUR): 600000.0
Participants: 5
Project status: CLOSED

As a coordination and support measure this project is aimed to increase the efforts of the EC and the Member States in pursuing the strategic objective of Europe’s reindustrialization and growth during Luxembourg’s Presidency of the Council of the EU (June-December 2015) through the organization of the MANUFUTURE 2015 conference focused on options for strategic investments in European manufacturing. The main objective of the conference is to identify and endorse new policy instruments, business models, support mechanisms and technologies that could help to strengthen and improve the manufacturing base in Europe given the existing regulatory framework and the constrains that EU manufacturers face on the global markets at this critical time. More specifically, the conference aims to involve in the consultation process over 750 stakeholders (policy makers, business leaders, innovators and academics) representing all manufacturing sectors in the EU27. The conference is structured along three major themes, including the issues related to widening access to finance for reindustrialisation and growth, moving European industry to the higher end of value chains, and creating synergy of support initiatives at EU level and in Member States with increased participation of financial markets. For each theme a list of sub-issues to be addressed by speakers have been identified through a consultation process with the High Level Group of Manufuture and the Ministries of Economy and Higher Education and Research which have endorsed the initiative of LXI to host this event. The proposal addresses the work programme topic NMP-38-2014 which calls for organising an event of a major strategic nature during the EU presidency of Luxembourg that could contribute towards creating better synergies between public and private initiatives to the benefit of the coherence of the overall actions within the field of research and innovation for the manufacturing sector.

Keywords: manufacturing industry,technology platform
Power Amplifier Design for Wideband Communications (PADWIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Power amplifier (PA) design for wideband communications is a hot topic in electronics, since microwave PAs with high linearity, efficiency and bandwidth represent an enabling technology for wireless/mobile communications enhancement. The proposal aims to develop the clipping contours method in continuous modes PAs. The continuous modes provide sets of harmonic loads that can be exploited to achieve high efficiency operation of the active device. The clipping contours permit to broaden these sets of harmonic loads, relaxing the requirements on matching networks but still controlling the target PA performance. The host laboratory recently published cutting-edge results on both methods. The candidate will work to achieve important objectives: -Extension the theory of clipping contours to third and higher harmonics -Creation of a novel design tool for clipping contours in continuous modes -Development of matching network synthesis techniques to achieve the loads provided by the tool -Design of PAs prototypes for high power base stations in the 1.8-2.7 GHz band -Embedding of clipping contours in a Doherty PA prototype They will be achieved thanks to the host laboratory excellence, to the young and promising researcher’s ability, and to an effective planning. Each step will follow a solid procedure: -Literature survey and theoretical formulation of the method -Implementation of novel method by design examples -Experimental characterization for validation -Exploitation: dissemination and public engagement The project is of great relevance. It will impact on the industrial leadership of EU: microwave PA is an enabling technology in many competitive markets. Power efficient base stations will contribute to the EU target of increasing overall energy efficiency. The project will provide to the researcher the skills and the scientific impact to boost his career trajectory. The host will benefit of the project, increasing its reputation and acquiring skills from the candidate.

Keywords: power amplifier,microwave,communications,wideband,base station,solid state circuit design,energy efficiency,linearity,waveform engineering,matching network,algorithm