Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
STRATEGIES TO STRENGTHEN EUROPEAN LINGUISTIC CAPITAL IN A GLOBALISED WORLD (MultiLX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Norway,Spain,Germany,Italy,United Kingdom,Finland,Ireland,Switzerland
Call: Strategies to strengthen the European linguistic capital in a globalised world (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2956480.0
EU funding (EUR): 2956480.0
Participants: 10
Project status: SIGNED

This research project will collect and analyse evidence to inform transformation of language policy in Europe. Increased mobility of people across territories has altered the linguistic make-up of Europe, while rapid developments in AI and other digital technology have revolutionised the way people communicate. However, EU language policy has been slow to respond to the pace of these changes. Our challenge in an increasingly diverse, digital and multilingual Europe is to reform language policy to shape a future for young people which is inclusive, democratic and equitable. We will address this challenge by providing policy makers with comprehensive evidence of the communicative practices and language ideologies of young people in Europe. We will examine how young This research project will collect and analyse evidence to inform transformation of language policy in Europe. Increased mobility of people across territories has altered the linguistic make-up of Europe, while rapid developments in AI and other digital technology have revolutionised the way people communicate. However, EU language policy has been slow to respond to the pace of these changes. Our challenge in an increasingly diverse, digital and multilingual Europe is to reform language policy to shape a future for young people which is inclusive, democratic and equitable. We will address this challenge by providing policy makers with comprehensive evidence of the communicative practices and language ideologies of young people in Europe. We will examine how young people use language in multiple locations in Europe, focusing on their communication in digital, creative and everyday contexts. We will observe young people’s interactions in six cities in five countries, and elicit their perspectives on language, identities, heritage, belonging and investment. This project will equip policy makers with the evidence necessary to introduce equitable, inclusive language policy fit for the digital, multilingual age.

Keywords: ethnographic
Towards pediatric molecular imaging: development of a low-dose and high-performance Total Body PET scanner (PHOENIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1464841.24
EU funding (EUR): 1464841.24
Participants: 1
Project status: SIGNED

PositrPositron Emission Tomography (PET) constitutes the imaging modality of excellence in nuclear medicine. Conventional whole body (WB) PET are used for both adult and pediatric studies. However, these scanners are not large enough to image the entire infant body, are not optimized in terms of sensitivity imposing the injection of high radiotracer doses and their spatial resolution is as best 3-5 mm at the center of scanner, which is not enough for visualizing small lesions. Moreover, since PET imaging requires the injection of a radiotracer compound, its use is compromised in pediatric due to radiation regulations and patient safety. To overcome these limitations, I aim to develop an affordable high-performance, high-sensitivity total body (TB)-PET for pediatric imaging. The system, named PHOENIX, targets for a high effective sensitivity of x25-30 the one of clinical WB-PET. To achieve this goal, we propose a large axial scanner of 54.5 cm with a bore diameter of 32 cm to cover all organs of children -without becoming claustrophobic- and, thus, permitting for dynamic multi-organ studies. For the best cost-performance tradeoff, the PHOENIX detectors would be based on semi-monolithic BGO crystals coupled to SiPMs. This design allows characterizing the light distribution profiles to retrieve photon depth of interaction information (resulting in a uniform image spatial resolution <3 mm) while simultaneously providing time-of-flight (TOF) capabilities. To offer significant TOF information, I aim to exploit the low Cherenkov light yield produced in BGO. We will implement a scalable custom readout circuit composed of 3- stages: i) signal multiplexing, ii) event classification -Cherenkov and Scintillation-, and iii) commercial ASIC adaptation for digitization. Developing the PHOENIX scanner constitutes a major research and technological challenge. If successful, will promote PET imaging of children, improve its diagnostic capabilities, staging and response assessment.

Keywords: molecular imaging,positron emission tomography pet,total body tb pediatric pet,compton kinematics,readout electronics multiplexing scheme,semi monolithic scintillators,bgo scintillators,silicon photomultipliers sipms,photon depth of interaction doi,time of flight tof,cherenkov and scintillation radiation,
Gate2Brain. Medicines beyond barriers. (Gate2Brain)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-04-01
End date: 2025-12-31
Duration (months): 33.0
Total project cost (EUR): 3529656.25
EU funding (EUR): 2470759.0
Participants: 1
Project status: SIGNED

In 2019, 30 million people worldwide were diagnosed with some form of CNS disorder and most of them lack effective treatment. This is largely explained by the fact that most of developed therapeutic molecules do not contain the appropriate properties to cross the BBB. Consequently, CNS disorders are the first cause of disability, and the second of mortality worldwide. Gate2Brain is a technologic platform based on a set of small peptide-shuttles that have the capacity to cross the BBB and carry to the CNS therapeutic cargoes that cannot reach the brain unaided. G2B-002, our flagship product, is a new therapeutic approach to fight against untreatable pediatric brain tumors with intact BBB. G2B novel delivery technology provides a non-invasive, non-antigenic, stable, soluble, and receptor-specific way to transport drugs across the BBB to reach the CNS. Our technology has the potential to be applied in a wide number of therapeutic areas and in transport through various biological barriers.

Keywords: immunotoxicity,peptide synthesis,drug shuttles,blood brain barrier,therapeutic molecules,paediatric oncology,peptide shuttles,brain drug delivery systems,drug delivery,central nervous system,glioblastoma,drug development,pharmaceutical industry,brain delivery,solubility,peptides,peptide chemistry,peptide drug conjugates
Changing practices and Habits through Open, Responsible, and social Innovation towards ZerΟ fοod waste (CHORIZO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Norway,Italy,Hungary,Slovenia,Spain,Denmark,Greece
Call: Evidence-based decision-making to change social norms towards zero food waste (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 6095569.0
EU funding (EUR): 6095569.0
Participants: 16
Project status: SIGNED

CHORIZO aims to improve the understanding of how social norms (rules or expectations that are socially enforced) influence behaviour related to FLW generation. To significantly accelerate progress towards zero food waste, CHORIZO aims to use this knowledge to increase the effectiveness of decision-making and engagement of food chain actors, in changing social norms towards zero food waste. To achieve its aim, the project will provide evidence on the role of existing social norms in actors’ FLW behaviours through translating results from previous FLW actions into evidence and generate new evidence on social norms & FLW behaviours. Second, CHORIZO will embed these research results into innovation products that can foster change of FLW-related social norms. These products include more effective (sector-based) guidance, communication & science education packages and capacity building actions. CHORIZO employs real-life Case Studies (CSs) to serve its three interlinked purposes: (i) to provide information and data on the context and impact of previous FLW prevention/reduction actions undertaken by the Case Study members, thus enriching the evidence-based analysis on previous FLW actions; (ii) to generate new evidence on the interaction between social norms, behaviour and food waste, to feed into the project’s FW models and innovation products; (iii) to validate the communication & science education packages of the project. Moreover, on the technical side, CHORIZO will utilise advanced modelling techniques to produce solutions that integrate behavioural and economic theories and integrate gender and intersectional analysis to interpret social norm and behavioural data and to effectively engineer innovation processes and outputs.

Keywords: behavioural change,social norms
A novel multi-functional elastin-like recombinant hydrogel for the prevention of scar tissue formation following a myocardial infarction: "ELR-SCAR" (ELR-SCAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Ireland,Spain,Germany,Poland,Belgium,Netherlands,Lithuania
Call: Smart and multifunctional biomaterials for health innovations (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 4462392.48
EU funding (EUR): 4462392.23
Participants: 8
Project status: SIGNED

The ELR SCAR project aims to complete preclinical validation of a novel biomaterial, an elastin-like recombinant (ELR) hydrogel, to prevent scar tissue formation in the heart following myocardial infarction (MI), commonly called a heart attack. MI is the endpoint of ischaemic heart disease (IHD). In Europe, the highest rates of IHD worldwide equal ~26.5 million patients. Standards of care interventions after MI have serious limitations in treatment efficacy (many patients are still at risk of developing heart failure) and patient safety. There is a clear medical need for new treatment solutions that prevent scar tissue formation and irreversible cardiac remodelling. Our robust preclinical dataset so far indicates that the ELR hydrogel has this promising functionality via multiple unique characteristics: it provides selective cell adhesion to the endocardium, providing a barrier to scar tissue formation; it offers high biospecificity to the ischaemic microenvironment, and it has an enhanced biodegradability, allowing for safe disintegration in the body. To facilitate endocardial delivery of the ELR hydrogel, we will develop a minimally invasive endocardial catheter in this project. Both components (hydrogel + catheter) will be advanced to the preparedness level for a first-in-human (FIH) validation study for the application as therapeutic intervention post-MI (to be performed after the project). In addition, we will develop the regulatory and IPR strategies in preparation for this clinical validation step. Considering the high societal impact of ischaemic heart disease (IHD) and MI, we will also develop a solid health economic evaluation of possible savings and patient benefits. ELR-SCAR will transform and fundamentally improve clinical practice, resulting in reducing the enormous burden that MI and its leading cause, IHD, place on society and the individual patient.

Keywords: biomaterial,ischaemic heart disease,cardiac remodelling,endocardial catheter,biospecific,enhanced biodegradability,selective cell adhesion to the endocardium,tissue regeneration,non transmural
Enabling Circular Value Chains via Production Digitization and Human Empowerment (ENCIRCLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Greece,Germany,Ireland,Italy,Spain,Türkiye,United States,United Kingdom
Call: Technologies/solutions to support circularity for manufacturing (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 5990676.25
EU funding (EUR): 5990676.25
Participants: 15
Project status: SIGNED

Humanity has exceeded planetary boundaries as is evident by the ongoing climate crisis. The linear economic model of ‘produce-use-dispose' has a major role in this, having driven manufacturing to operate in open-loop and even disregard for the environment. The transition to circularity is an imperative goal, yet there is a very slow uptake of circular practices and business models. ENCIRCLE aspires to accelerate this transition through technologies and solutions that optimize manufacturing towards sustainability and incentivize companies and consumers to think and act circularly. ENCIRCLE proposes a novel framework for environmental impact assessment via Digital Twins and Soft Sensors, incorporated in a virtual production line. Utilizing this virtual environment as a simulation and training space for AI, ENCIRCLE will decarbonize manufacturing, searching for sustainable production configurations and designs that reduce environmental footprint without compromising quality. This virtual space will be used for workforce training through gamification, cultivating new skills and fostering a new circular mindset. ENCIRCLE will follow a human-centered design and propose a symbiotic ecosystem of humans and AI through explainable Human-in-the-Loop methodologies. Building on the Digital Product Passport concept and product traceability via IoT and blockchain, ENCIRCLE will support circular business cases through a Digital Marketplace. On the producer’s side, a circular CRM, will enable companies to track their products and offer personalized, circular products and services. On the consumer’s side, a mobile app will empower users with sustainable consumption choices, expanding the lifespan or salvaging the remaining value of old products. ENCIRCLE will also explore the legal and ethical implications of its research, validating its research outcomes and hypotheses, through a series of demonstrators across the entire value chain.

Keywords: digital twins,simulation for sustainability,reinforcement learning,active learning,artificial intelligence,blockchain,dpp,digital marketplace,circular business cases,human centered ai
Social and hUman ceNtered XR (SUN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Germany,Malta,Belgium,Switzerland,United Kingdom,Spain
Call: eXtended Reality Technologies (RIA) (HORIZON-CL4-2022-HUMAN-01, 2022)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 7482542.5
EU funding (EUR): 7482542.5
Participants: 19
Project status: SIGNED

The Social and hUman ceNtered XR (SUN) project aims at investigating and developing extended reality (XR) solutions that integrate the physical and the virtual world in a convincing way, from a human and social perspective. The virtual world will be a means to augment the physical world with new opportunities for social and human interaction. We will address the following limitations: ● Lack of solutions to develop scalable and cost-effective new XR applications; ● Lack of convincing solutions for mixing of the virtual and physical environment; ● Lack of plausible and convincing human interaction interfaces in XR; ● Barriers due to resource limitations of end-user devices; We will develop solutions to surpass current limitations, including: ● Development of scalable solutions to obtain plausible and convincing virtual copies of physical objects and environments; ● Development of solutions for a seamless and convincing interaction between the physical and the virtual world; ● Development of wearable sensors and haptic interfaces for convincing and natural interaction with the virtual environment; ● Development of artificial intelligence-based solutions to address current computing, memory, and network limitations of wearable devices; The developed solution will be demonstrated in three real-life scenarios: 1 XR for rehabilitation after accidents or diseases. 2 XR in the industry to increase safety and improve social interaction among workers. 3 XR to remove interaction barriers for persons with disabilities.

Keywords: artificial intelligence
Printed Computing: Enabling Extremely Low Cost Pervasive Near Sensor Computing (PRICOM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2499286.25
EU funding (EUR): 2499286.0
Participants: 1
Project status: SIGNED

A large number of important domains - such as fast moving consumer goods and personalized medicine - have still not seen the benefits of computing, mainly due to high production costs of rigid silicon technologies. Printed electronics based on additive manufacturing processes holds promise of meeting cost and conformity needs of such applications. However, the realization of traditional digital processor architectures is infeasible due to constraints of low-cost manufacturing, such as form factor, low device count, large feature sizes, and high variations. The fundamental research question, hence, is how to perform accurate, reliable and energy-efficient classification computing to meet target applications’ requirements within the constraints of additive printed manufacturing. The aim of PRICOM is to make breakthroughs by developing unconventional mixed-signal classifier computing paradigms together with their hardware realization and mapping based on additive printing technologies. This enables to significantly reduce the hardware footprint, and directly process analog sensory inputs while achieving high classification accuracy. Nevertheless, it is a major challenge as analog computing is very sensitive to variations, and at the same time additive manufacturing is inherently prune to printing variations. I aim at closing this gap by 1) utilizing the inherent tolerance of neuromorphic computing to variations with special hardware primitive design and training algorithms, 2) designing novel variation-aware physical design algorithms, and 3) developing an iterative tuning flow exploiting unique features of additive manufacturing. The feasibility of multi-disciplinary research of PRICOM is underpinned by my unique cross-layer expertise and will be tested by fabrication-based demonstration of printed computing systems. PRICOM can enable proliferation of computing in consumer market and personalized medicine, bringing economical gains and improving quality of life.

Keywords: machine learning classifier hardware,printed electronics,resource constrained machine learning,electronic design automation,physical design,neuromorphic computing,computer architecture,design space exploration,reliable computing
Stress-Induced Preconditioning for Resilient Engineered Living Materials in Probiotic Architecture (PRO-TECTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 182717.52
EU funding (EUR): 182717.52
Participants: 2
Project status: SIGNED

Buildings are an essential part of human life, providing shelter, spaces for work, and hubs for community activities. However, conventional construction methods have a big negative impact on the environment. To achieve sustainability, alternative approaches using natural and environmentally friendly materials, such as wood, are being employed. Regenerative sustainability takes this a step further, not only by minimizing harm but also by creating a net positive impact on both the environment and the community. Engineered living materials (ELMs) represent an innovative frontier in realizing regenerative sustainability. The aim of PRO-TECTURE project is to develop more resilient and efficient ELMs by preconditioning living fungal cells (biofilm used as ELM) with abiotic stress. Previous research has shown that exposure to mild stress can trigger adaptive responses, preconditioning biological systems to be more resilient to future stressors. The PRO-TECTURE project will use stress preconditioning to enhance the resilience of ELMs, investigating the existence and duration of stress memory, as well as intraspecies stress communication through secreted molecules. Furthermore, given the ER’s background in biomedicine, the project will explore the possibility of interkingdom stress communication between pre-stressed fungi and human cells. By integrating ELMs into building practices, it is anticipated that these structures will not only minimize negative environmental impacts but also actively contribute to environmental restoration and enhance human well-being and health in the built environment. The PRO-TECTURE aims to stimulate innovation and facilitate knowledge transfer between the host and the ER by establishing a robust research network, organizing events, mentoring young researchers, and managing projects. Through this fellowship, the ER will gain advanced research and scientific skills, acquiring new competencies to achieve professional maturity and independence.