Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PermeAbility - A non-invasive, side-effect-free diagnostic kit for intestinal disorders (PermeAbility)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Inflammatory Bowel Disease (IBD) is a form of acute inflammation to the small intestine that causes ulcers and extensive damage of the gut barrier causing it to rupture. This causes bleedings, abdominal pain, diarrhea, and a dramatic reduction of the quality of life. The intestinal barrier is normally a very well organised structure in which the cells are tightly connected maintaining the barrier. Moreover, IBD lesions compromise this intestinal organization and increases intestinal permeability, which is called leaky gut syndrome (LGS) being also a pre-disposing factor for several other health problems. LGS compromises digestion of food particles and removal of toxic waste products, and allows bacteria to "leak" through the intestine to the blood stream. Besides in IBD, LGS is also common in people with health conditions such as obesity, rheumatoid arthritis and type 2 diabetes. Even though IBD poses significant threats to a patients’ health and a heavy direct and indirect economic burden, diagnosis of this condition is still limited assessing indirect parameters like general inflammation markers in plasma and stool and evaluation based by comparison on the patients symptoms description. The direct measures are also performed but are restricted to very invasive methods like biopsy or solely qualitative like MRI and microcapsule colonoscopy. In this way it is reported in several clinical articles a clear need for new diagnostic methods in IBD reinforced by facts like 35% of the performed surgeries for treatment revealing unnecessary and 1.9 billion people worldwide at risk for early lesions and IBD development not being diagnosed. In this way clinical practice urges for new methods for the assessment of lesions in the intestinal wall. Lifetag’s has developed PermeAbility, a new proprietary test to measure intestinal permeability to better select patients at high risk of IBD , leading to better informed clinical decision making, diagnosis, and treatment.
Merkel cell polyomavirus Oncogenic Network (MONET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 196707.85
EU funding (EUR): 196707.84000000003
Participants: 2
Project status: CLOSED

The aim of the MONET project (Merkel cell polyomavirus Oncogenic Network) is to provide a state-of-the-art understanding of Merkel cell carcinoma (MCC) tumorigenesis. Viral pathogens are estimated to be responsible of ~12% of cancers worldwide and represent useful models for the study of oncogenesis mechanisms. Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine skin cancer detected in ~2500 patients per year in Europe and has recently been linked with a clonal integration of the Merkel Cell polyomavirus (MCPyV) in more than 80% of cases. MCPyV is a 6-protein encoding system, expressing only two proteins with reported oncogenic functions. This limited proteome size thus allows system-wide study of its associated oncogenic mechanisms. This multi-pronged project consists of: (i) identifying the critical interactions of viral and host proteins in MCC oncogenesis; and (ii), using NOD scid mice cell line derived xenografts (CDXs), validate MCPyV host-proteins drug targeting strategies to combat MCC tumorigenesis. Using cutting-edge mass spectrometry-based techniques combined with CRISPR interference approaches in relevant human cancer cell systems, these studies will uncover new protein-protein interactions essential for tumorigenesis. MCPyV+ MCC CDXs will be used to establish the functional relevance of novel virus-host protein interactions and to assess the therapeutic potential of targeting these host interactors as anti-cancer strategies. The application of these proteomic and functional approaches will allow for a better understanding of MCPyV-associated carcinogenesis. In a broader view, it will define a new framework for identifying druggable targets in pathogen-driven cancers. This project will underpin future translational researches, and hence appears as a fundamental step for therapeutic development.

Keywords: merkel cell polyomavirus,molecular mechanisms of oncogenesis,crispr interference,drug target discovery
Exploring bacterial Quorum Sensing Infochemicals and hydrolytic Proteins linked to marine Particle degradation (QSIPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: TERMINATED

The ocean is by far the largest reservoir for carbon dioxide (CO2) on Earth and represents a driving force for climate mitigation. Through photosynthesis, active marine microorganisms (e.g. phytoplankton) convert atmospheric CO2 into biomass, where the majority of it is cycled in the surface waters by diverse processes including bacterial respiration and hydrolysis. Some of this biomass is exported as particulate organic carbon (POC) into the deep ocean, where bacterial cells play a critical role in regulating the efficiency of carbon export because they colonize and enzymatically hydrolyze POC as it sinks . A recent study suggested that signaling mechanisms within particle-associated bacterial communities enhance the activity of hydrolytic proteins involved in POC degradation. This overlooked process, known as quorum sensing, might impact the amount of carbon sequestered in the marine environment and ultimately affect the rate that CO2 is removed from the atmosphere. Quorum sensing (QS) involves the excretion and reception of distinct signaling molecules, but the biogeochemical implications of these bacterial “conversations” are poorly understood. To date, only a few culture-independent studies on QS in the marine environment have been carried out. This project will elucidate the role of QS systems among marine bacteria in triggering the synthesis of specific infochemicals and hydrolytic proteins, as well as its impact on shaping particles and particle-associated bacterial communities. Proposed methods include mass spectrometry, proteomics, three-dimensional particle imaging, molecular assessment of bacterial assemblages, and in situ localization of bacteria on intact particles. The outcome of the project will provide critical information on the importance of QS in regulating the efficiency of POC degradation in the ocean, which is necessary to understand and predict future climate scenarios.
Adaptable Platform for Active Services Exchange (AnyPLACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Belgium,Portugal,Portugal
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 2974263.75
EU funding (EUR): 2534389.25
Participants: 8
Project status: CLOSED

The AnyPLACE (Adaptable Platform for Active Services Exchange) project intends to develop a modular smart metering platform. The targeted system aims to provide a bidirectional service exchange gateway that enhances the interaction between end users, market representatives, electricity network operators and ICT providers. The proposed solution will allow performing energy remote metering (electricity, gas, heating and cooling), exploiting electricity networks in a more efficient manner and turning end users in active energy markets players through their engagement in demand response programs. Moreover, the utilization of the AnyPLACE platform to actively manage and control electricity networks will also allow mitigating operational problems related with the variability of renewable based generation. To enable the development of an effective modular and flexible platform, an analysis to the different regulatory frameworks, energy/telecommunications standards, potential scenarios of deployment, technical requirements of the solution and technologies currently available will be performed. A modular and plug and play SW and HW platform will be developed in parallel with current and expected regulatory initiatives and standards. A cost-benefit analysis on different possible configurations will be developed, to ensure that appropriate configurations, or even retrofitted solutions, are designed for each context and their cost do not exceed 100€. A set of prototypes will be built with different combinations of modules to deal with different scenarios of application, which will be tested in a smart grid laboratory environment and in a field trial, providing a real-world assessment of their performance. Near-market prototype versions will be produced, accomplishing the project knowledge and technology transfer to industrial consortium partners as well as general industry and service providers. The AnyPLACE project will also address public acceptance of the designed solutions

Keywords: smart metering
Harmonic Analysis and l-adic sheaves (HAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2022-09-30
Duration (months): 84.0
Total project cost (EUR): 1569488.0
EU funding (EUR): 1569488.0
Participants: 1
Project status: CLOSED

In recent years there has been impressive development of the higher category theory and in particular development of the categorical counterpart of the Langlands conjecture over fields of finite characteristic. But until now, this development has had little bearing on the classical problems which deal with spaces of functions. The main goal of this proposal is to build the technique to apply the category theory to classical problems. Of course on the way I will have to deal with problems in the categorical realm. The first part of the proposal deals with construction of characters of irreducible representations of reductive groups over local nonarchimedian fields F in terms of traces of the Frobenious endomorphisms which should lead to the proof of the "Stable center conjecture" at least for representations of depth zero. The second part is on the extension of the definition of L-functions of representations of reductive F-groups corresponding to an arbitrary representation of the dual groups. As it is now, the definition is known only for very special representations of the dual group and only in the case of classical groups. The third part is on the extension of the classical theory to representations of Kac-Moody groups over local fields.

Keywords: representation theory,infinity categories,l adic sheaves
Science at the Fair: Performing Knowledge and Technology in Western Europe, 1850-1914 (SciFair)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Belgium,Belgium
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1498857.0
EU funding (EUR): 1498857.0
Participants: 2
Project status: SIGNED

SCIFAIR aims to conduct pioneering research on the role itinerant showpeople played in the transmission and popularisation of science and technology at Western European fairgrounds between 1850 and 1914. At a time when modern communication media were not yet in place and only a minority of the population could read, large groups of people were actually dependent on travelling performances and displays for information: in so-called anatomical cabinets, zoological and anthropological museums and scientific theatres, showpeople demonstrated ‘wonders of nature’ and spectacular scientific developments. The project advances the hypothesis that the fair in this period was not merely a local folk tradition, but a hub for international exchange in which itinerant entertainment played a pivotal and modernising role in the circulation and popularisation of science amongst people across the social spectrum, relying on efficient international networks. In order to test this hypothesis, the project will bring together a multilingual and multidisciplinary team of researchers that will combine methodologies from theatre and performance studies with perspectives from history of science, media studies and digital humanities to analyse practices of science performance across national boundaries and map transnational networks of Western European fairground theatres. SCIFAIR will not only study explicit didactic discourses but also analyse how implicit knowledge and social values of health, gender, nation, class or race were challenged or reinforced. By analysing the fair as a performative event, the project will advance a conceptual shift in media historiography to a historiography of media performance and thus contribute to our understanding of the social and cultural role of the fair in knowledge circulation. SCIFAIR will thus make a major contribution to media and performance history, as well as to the history of science and knowledge transfer.

Keywords: media archaeology,fairground history,history of popular performance,history of popular culture and media
Establishing services enhancing the innovation management capacity of the Slovak SMEs in the Enterprise Europe Network in 2017-2018 (H-BISS Slovakia 2018)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Slovakia,Slovakia
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 122035.0
EU funding (EUR): 122035.0
Participants: 5
Project status: CLOSED

Main objective of the action is improving the innovation management capacity of two SME target groups: (1) Beneficiaries of the SME Instrument by provision of the specialised Key Account Management services, and (2) SMEs with significant innovation activities and a high potential for internationalisation through the targeted Enhancing the innovation management services. The proposed action will implement 54 seven-day service packages during the pilot action in 2017-2018.

Keywords: eimc,innovation management,enterprise europe network,sme instrument
Cerenkov Imaging for Surgical Margin Assessment (CerISMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2015, 2015)
Start date: 2015-12-01
End date: 2019-06-30
Duration (months): 43.0
Total project cost (EUR): 2351461.25
EU funding (EUR): 2351461.25
Participants: 1
Project status: CLOSED

Cancer is not only a leading public health challenge in Europe, it is also a growing economic challenge. Over three million cases are currently diagnosed each year across the continent. Forecasts show that by 2020 almost half of the population will be diagnosed with the disease in their lifetime. The cost of cancer for the EU is €126 billion per year and rising. The health and economic implications of cancer therefore provide a compelling business opportunity for technologies that can improve health outcomes and reduce treatment costs. Surgery remains one of the primary treatments for cancer, yet surgeons lack the tools to identify accurately and remove cancer during an operation, resulting in costly re-operations and negative health ramifications. Lightpoint Medical has developed a molecular imaging camera (LightPath™) based on a breakthrough imaging modality, Cerenkov Luminescence Imaging (CLI). The technology can provide surgeons with real time intraoperative analysis of cancerous tissue to ensure the complete removal of cancer in a single operation. The device provides the potential for a dramatic reduction in costly re-operations and adjuvant therapies across a wide range of major cancer indications, proving not only an innovative solution for healthcare providers, but also a tool to substantially reduce cancer care costs. CerISMA is proposed as a multi-centre clinical trial to confirm the clinical efficacy of LightPath™ in a lead cancer indication and to evidence the health economic impact of the technology. The project is vital for the company’s growth, fundamentally underpinning the company’s ambitious sales and marketing strategy across strategic target territories in Europe and the US.

Keywords: breast cancer,cancer treatment,surgical margins,re operations
Women, Politics and Media Framing (WPMF) in the UK and in Israel – Tackling Western Democracies' Gender Inequality in Politics (WPMF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The goal of this project is to systematically analyse gender inequality in politics in a comparative perspective, as portrayed in the mainstream media, and develop operative actions to reduce such inequality in politics in the European context. This corresponds to H2020 Work Programme for 2016-2017 of reversing inequalities in Europe, and more specifically to the EU Strategic Engagement for Gender Equality 2016-2019. Applying the theoretical framework of developmental theory, this study examines whether changes occurring in the status of women in the UK and in Israel, as part of the structural and cultural transformations that this theory points to, seep into the political discourse surrounding women and politics over time. We use the print media to analyse relevant frames on women and politics during the study period (1979-2016 in the UK and 1969-2009 in Israel - in which women were realistic candidates/elected for premiership). In addition, we utilize a quantitative content analysis of the news and commentaries in newspapers to locate interpretive references to women and politics. A sub-set of these articles is used for an in-depth qualitative analysis to draw out the key themes surround the framing of women and politics. An important contribution of the research lies in the theoretical connection between the framing of women and politics to developmental theory's structural and cultural conditions. That is because the bulk of studies on framing gender and politics are descriptive and lack an empirically supported theoretical explanation of the changes in the framing of these issues. The findings of this research will help raising social, political and media awareness to the status of women and to women's issues in Europe, and encourage more women to take part in politics in Europe and worldwide by tackling stereotypical framing of women and politics issues and by suggesting operative steps to face backlashes to political gender equality in Western democracies.

Keywords: gender,politics and media,gender inequality,developmental theory,quantitative and qualitative research methods
SHARECITY: Assessing the practice and sustainability potential of city-based food sharing economies (SHARECITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-07-31
Duration (months): 70.0
Total project cost (EUR): 1860008.75
EU funding (EUR): 1860008.75
Participants: 1
Project status: CLOSED

With planetary urbanization fast approaching there is growing clarity regarding the unsustainability of cities, not least with respect to food consumption. Sharing, including food sharing, is increasingly being identified as one transformative mechanism for sustainable cities: reducing consumption; conserving resources, preventing waste and providing new forms of socio-economic relations. However, such claims currently rest on thin conceptual and empirical foundations. SHARECITY will identify and examine diverse practices of city-based food sharing economies, first determining their form, function and governance and then identifying their impact and potential to reorient eating practices. The research has four objectives: to advance theoretical understanding of contemporary food sharing economies in cities; to generate a significant body of comparative and novel international empirical knowledge about food sharing economies and their governance within global cities; to design and test an assessment framework for establishing the impact of city-based food sharing economies on societal relations, economic vitality and the environment; and to develop and implement a novel variant of backcasting to explore how food sharing economies within cities might evolve in the future. Providing conceptual insights that bridge sharing, social practice and urban transitions theories, SHARECITY will generate a typology of food sharing economies; a database of food sharing activities in 100 global cities; in-depth food sharing profiles of 7 cities from the contrasting contexts of USA, Brazil and Germany, Greece, Portugal, Ireland and Australia; a sustainability impact toolkit to enable examination of city-based food sharing initiatives; and scenarios for future food sharing in cities. Conducting such frontier science SHARECITY will open new research horizons to substantively improve understanding of how, why and to what end people share food within cities in the 21st Century.

Keywords: food consumption and waste,sharing economies,sustainable consumption,social practice,backcasting,urban transitions