Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The interaction and clearance of senescent vascular cells by the innate immune system (ICSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease , . Therefore, the aim of this research is to understand why senescent cells accumulate later in life for the purpose of identifying potential therapeutic strategies for eliminating senescent cells. This project, founded in an emerging field of ageing research, will determine the interaction and clearance of senescent cells by ageing innate immune cells. Using in vitro, ex vivo and in vivo approaches the fellow will delineate the mechanisms of interaction between senescent vascular cells and the innate immune system and how they are impacted by age. This will significantly advance knowledge and lead to novel molecular targets to explore for eliminating age-associated vascular senescent cells. Since the field of cellular senescence is predominantly centred within molecular cell biology and cancer, this coordinated cross-disciplinary and cross-sectorial approach will provide novel insight into vascular senescence. Through an ambitious research training programme, the fellow will develop scientific, complementary and transferable skills in metabolism, innate immunity and vascular function in age-related disease from Aston, UK with intersectorial training to develop small molecule drugs from Redoxis SB, SWE; evaluate drug efficacy in models of ageing (Erasmus, NL); in the context of clinical cardiology (Aston/City Hospital, UK). It will deepen collaborations for partners, provide new techniques to the hosts and enhance the skills of exceptionally talented research fellow, with over ten years’ experience in the field of cellular senescence, forward as a research leader with experience of working effectively across sectors.

Keywords: cell senescence,age related pathologies,therapeutic strategies,aging research,innate immune cells
Immune Response and Social Cognition in Schizophrenia (iRELaTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1477622.0
EU funding (EUR): 1477622.0
Participants: 1
Project status: CLOSED

Schizophrenia, affecting 0.5-1% of the population, is ranked by the World Health Organisation as more disabling than paraplegia or blindness in 18-34 year olds. Current treatments, developed over 50 years ago, are only partly effective in treating this disability, and new treatments are lacking. To address this treatment impasse, this project aims to develop and test a novel immune based model of deficits in social cognition – the set of mental operations that underlie social interactions (e.g. emotion recognition, theory of mind) and strongly predict social disability in schizophrenia. Based on recent discoveries in schizophrenia genetics, this project asks: (1) are genetic causes of deficits in social cognition mediated by effects on immune function during development and (2) does early social environment moderate these effects? To address these questions, the project has two parts. Part A focuses on neuropsychological and neuroimaging studies of social cognition in patients and healthy adults so as to (1) provide an innovative characterisation of the effects of inflammatory markers (e.g. pro-/anti- inflammatory cytokines) on social cognition, (2) establish whether these markers mediate the effects of recently identified genetic risk loci on schizophrenia, and (3) identify to what extent early social environment (e.g. parental relationships, childhood trauma) moderates this relationship. Part B focuses on behavioural and pharmacological studies in mice to (1) establish the causal effects of early immune challenge and early social environment on social cognition, and (2) test the translational benefits of anti-inflammatory treatment to normalize the resulting deficits. By validating an immune based model of schizophrenia, this project has the potential to move beyond current (dopamine based) treatments, and suggest groundbreaking alternatives for understanding and treating social disability in this and other neurodevelopmental disorders.

Keywords: social cognition,emotion recognition,theory of mind,social attributions,immune function,inflammatory response
Europe-Japan Accelerator Development Exchange Programme (E-JADE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Israel,Germany,Spain,Poland,Serbia,Switzerland,France,France,France,United Kingdom,United Kingdom,United Kingdom,Japan
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2281500.0
EU funding (EUR): 1179000.0
Participants: 18
Project status: CLOSED

The Europe-Japan Accelerator Development Exchange Programme (E-JADE) addresses the urgent need of exchange of ideas on R&D and implementation of future accelerators for particle physics. It does so by exchanging accelerator scientists and experts between Europe and Japan. The recent European Strategy for Particle Physics and the Japanese Roadmap identify similar pressing goals of research for the next decades. The strategy emphasises the exploitation of the Large Hadron Collider (LHC) and its upgrades, preparation of the cases for new facilities at the energy frontier (FCC or CLIC), identifies the opportunities for electron positron collisions (ILC), particularly after the recent discovery of the Higgs boson, and recognises the need for a long baseline neutrino programme at J-PARC in addition to the BELLE II programme of KEK. The user community at these facilities is international: a strong contingent of Japanese researchers from KEK and universities work on the ATLAS experiment, highly qualified experts from KEK contribute to the LHC itself, some two thousand researchers worldwide have signed the ILC design report and several hundred physicists are actively engaged in accelerator studies, such as on ATF to explore concepts generally applicable to linear colliders. The J-PARC neutrino experiment, with a strong European participation, has recently published important scientific results. The planned exchange of staff of leading European Laboratories and Universities with two prominent Japanese partners, KEK and University of Tokyo will focus on the most critical subjects and profiles namely on the design, R&D and prototyping of the future accelerator facilities mentioned above. Key objectives beyond technical progress are related to sharing of technical knowledge, project organisation, treatment of multiple safety codes for technical equipment, purchase methodologies and industrial capabilities, innovation and networks to significantly advance these projects.

Keywords: particle accelerator technology collaboration
Materials Synergy Integration for a Better Europe (BET-EU)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Finland,United Kingdom,Portugal,Portugal
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999363.75
EU funding (EUR): 999363.75
Participants: 6
Project status: CLOSED

The proposal integrates synergies in the area of Advanced Functional Materials & Nanotechnologies for a better Europe, targeting the specific field of paper electronics, aiming to bridge gaps and capacity building in science and technology identified in Uninova & I3N cluster by twinning with outstanding EU institutions with unique capabilities to progress on fundamental understanding of nanocellulose & device properties at the micro/nanoscale; to manufacture paper electronics, predict materials and devices behavior and their integration. These will master the Portuguese cluster to an international leadership position in this increasingly complex multidisciplinary science and technology field. Moreover, this will allow them to define a Strategic Research Agenda and a Science & Technology Roadmap for the future, with strong regional impact. The objectives of this proposal are tuned with the TWINN-2015 call “The specific challenge is to address networking gaps and deficiencies between the research institutions of the low performing Member States and regions and internationally leading counterparts at EU level” This is done by: University of Cambridge, one of the top Universities in the world, internationally-recognized leader in design and modeling of thin film electronic circuits and applications; Fraunhofer Institute for Ceramic Technologies and Systems, Dresden, Germany, among the world leaders in characterization of nanomaterials and device properties; VTT, Finland, among the world leaders in Printed Electronics, which will co-operate via: a comprehensive program of cross-fertilisation of scientists and technologists, education and hands-on training programs for new research staff, consolidation of acquired know-how, full integration and growth of supply chain in the emerging paper electronics field from advances in nanocellulose materials technology to innovation in device architectures up to their manufacturing.

Keywords: boosting advanced functional materials towards the renascence of paper electronics in europe,promoting to the extreme of excellence portuguese randd in advanced materials and nanotechnoligies
Food and Gastronomy as leverage for local development (FOODEV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-12
End date: 2018-05-11
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Food and gastronomy are increasingly recognized as elements of regional innovation strategies, contributing to regional and economic development both in rural and urban environments. On the other hand, in order to link research in food and gastronomy to that of sustainable development, it is necessary to draw from multiple disciplines, as food has a multifunctional character and the food system is heavily implicated in many public policy arenas. This proposal aims at implementing an inter-disciplinary research agenda able to determine under which conditions a certain place or region has been able to build on local features and to identify a successful sustainable development strategy based on food and gastronomy in the long-term. The project will consider the wider European policy debates on food and gastronomy as leverage for sustainable development, that will be coupled with systematic analysis of academic contributions on the topic across social and economic areas; explore factors contributing to sustainable development by the means of food and gastronomy in different projects/strategies, and according to different perspectives, will ensure to gain a systematic understanding of multiple issues and problems to be dealt with within each sector and how they interrelate, as emerging from each stakeholder category. This will build a more complex and network-like vision of knowledge, learning and innovation, which represent the concepts underpinning the emerging approach to knowledge transfer. The research action will develop reliable interdisciplinary evidence that can be used by policymakers to base their decisions on, contributing to closing the research and innovation gap through translational research approach, characterised by multi-disciplinary approaches allowing interaction between different spheres. This will contribute to the work programme by maximising experienced researcher’s contribution to knowledge-based economy and society.

Keywords: food,gastronomy,sustainable development,regional development,economic development,policymaking,tourism
Smart Library of Edutainment: technology and gamification at the service of Education (Smart Library)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Spain
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2018-12-31
Duration (months): 22.0
Total project cost (EUR): 1827500.0
EU funding (EUR): 1200000.0
Participants: 1
Project status: CLOSED

Children today are natives of technology, having frequent access to digital devices both at home and at school. Digital devices are today even more used than TV. Worryingly, the offering of high quality educational apps is very limited and expensive. Parents and educators are concerned about this and are actively searching for better alternatives. To help resolve these issues, Smile and Learn places technology at the service of education with the mission of helping children 2 to 12 years old learn while having fun using digital devices. Like the north American educational philosopher John Dewey, we believe that “if we teach today’s students as we taught yesterday’s, we rob them of tomorrow.” Our vision is to become the global leader in Edutainment (Entertainment plus Education). To do so we have developed the Smart Digital Library, a single platform of interactive games and stories that, as of today, provides access to up to 30 individual proprietary apps (100 apps by end 2018). The “Library” can be used at home, on the go or at school and provides “smart” recommendations to children, their parents and educators. In August 2016, Smile and Learn successfully completed phase I of SME Instrument, finalizing our first release of the Smart Library rolled out in real production environments both at pilot schools (today more than 100 schools use the Library, including 10 special education schools) and with families (+7,000 active users) in different markets, including the US, Spain, the UK, France, Mexico and Colombia, with very positive feedback. We already have more than 30,000 users worldwide with no marketing expenditure. We are now moving forward to make the Smart Library a global state-of-the-art product in the edutainment industry by scaling it up and rolling out a powerful dissemination plan, that we expect to conduct with the support of Phase 2 H2020

Keywords: ed tech,gamification,edutainment,children s education,apps,smart library,smile and learn,mobile,digital devices,education
Scenarios for integration of bio-liquids in existing REFINERY processes (4REFINERY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Research and Innovation actions
Countries involved: Spain,Hungary,Norway,Finland,Switzerland,France,Netherlands,Denmark,United Kingdom
Call: Development of next generation biofuel technologies (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2017-05-01
End date: 2021-06-30
Duration (months): 50.0
Total project cost (EUR): 5965473.71
EU funding (EUR): 5965473.71
Participants: 10
Project status: CLOSED

There is a strong need to develop new biofuels production technologies that can be integrated into existing infrastructures, leading to biofuels that are cost competitive compared to existing ones and conventional fuels, with the same level of performance and a lower carbon footprint. The 4REFINERY project will develop and demonstrate up to pilot, routes to the production of next generation biofuels from more efficient primary liquefaction processes integrated with upgraded downstream (hydro)refining processes, to achieve overall increased carbon yields of >45%. The strong consortium covering the full process value chain, will identify risk-mitigation pathways for successful implementation into existing refineries, including delivering a comprehensive toolbox for interfacing with existing refinery models. 4REFINERY will focus on optimal pathways for the transformation of bio-liquids from fast pyrolysis and hydrothermal liquefaction into advanced biofuels, through intermediate process steps (fractionation, stabilisation) combined with downstream co-processes technologies at different levels of severities (temperature, hydrogen consumption, carbon yield): co-Fluid Catalytic Cracking, co-hydrodeoxygenation and co-hydrotreating. The project will establish relations between product’s properties, the quality of renewable feedstocks and the main process parameters. The study of these combinations will allow a full understanding of the influence of feedstock and treatment processes on product characteristics, describing, analysing and providing insight into synergetic effects. Tangible results include add-ons to existing flow sheeting programs/unit model, with the objectives to analyze different scenarios for further implementation into existing archetype refineries, and to be deployed in existing in-house programming tools used by the oil companies. The financial resources mobilized by the 8 partners represent a total grant of 5 965 474 € with a global effort of 549 PM.

Keywords: hydrothermal liquefaction,pyrolysis,hydrotreating,fluid catalytic cracking,co fcc,biofuels,hydrodeoxygenation,risk governance,upgrading,conversion,biomass,eucalyptus,wood,toolbox
Generic phOtOnic Design MODules (GOODMOD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Generic photonic design software modules aims to improve current nanophotonic design technologies. To achieve this we will provide photonicGeneric photonic design software modules aims to improve current nanophotonic design technologies. To achieve this we will provide photonic design engineers with fast, high-performing photonic building blocks. The ambition of this phase is to complete the business plan for 5 different generic, highly optimized building blocks. A first step towards reducing development time and effort has been taken by composing circuit designs via standard building blocks implementing basic functionalities, which can be employed to compose more complex circuit-level functionalities for many different applications. However, the design time for each building block is still long, as they require to be modelled, simulated and laid out for every material platform, process and foundry available. The use of software modules will strongly impact the design procedure for experienced designers and newcomers. The main points of impact are by reducing the time, potentially up to 80%, and thus freeing design and layout resources, thus more work can be completed by the same number of design engineers, boosting efficiency and yield. More specifically for VLC, as its business model is based on providing services, reducing time by 80% will allow to increase economic benefit by a similar amount, and even more, introduce a product rather than a service on its business offering, which can be potentially scalable, friendlier towards external investment and ultimately more profitable than selling services. The complexity of generating and validating standard building blocks quickly scales up, and automation needs to be used to cover all possible blocks. This is considered key for maturing the technology and speeding product development in a market that is expected to grow at compound annual growth rates (CAGR) above 25% in the period 2015-2022, from $228M to $1.338M.

Keywords: photonics,semiconductors,nanophotonics,optics,photonic integrated circuits,nanoelectronics,electronic design automation