Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Redefining protective packaging by using waste wool to replace bubble wrap (WOOLA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Plastic packaging poses a significant environmental threat, contributing to pollution, biodiversity loss, and microplastic contamination. While bio-based alternatives are often seen as more sustainable, they are not without issues. Many rely on materials like PLA and other binding agents, which hinder natural biodegradation and require industrial composting. In fact, these materials can take up to 80 years to degrade without the aid of industrial facilities. Additionally, the production of bio-based plastics demands significant resources, such as farmland and water, that could be better utilized for food production. Sheep wool, on the other hand, presents a largely untapped opportunity for sustainable packaging. Globally, 40% of wool goes to waste, particularly low-grade wool unsuitable for textiles. However, this type of wool is an ideal material for protective packaging due to its durability and natural properties. Woola has developed a range of innovative packaging solutions, including envelopes and padding, all made from surplus sheep wool. Our groundbreaking material is entirely free of PLA or other binding agents, achieved through a unique process that modifies wool fibers using heat, pressure, and humidity. This additive-free approach ensures the material is not only highly sustainable but also industrially scalable. Woola’s packaging products are naturally biodegradable, versatile, and designed to meet growing demand for eco-friendly solutions, offering a superior alternative to both plastic and bio-based packaging options.
MBF-015. A FIRST-IN-CLASS DISEASE MODIFYING THERAPY TO HALT COGNITIVE DECLINE (Re-Spark)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Medibiofarma is a Spanish biotech company developing a first-in-class histone deacetylase (HDAC) inhibitor with the potential to halt cognitive decline. MBF-015 specifically targets HDAC 1 and 2 in the CoREST repressor complex, thereby reactivating the expression of neuroprotective genes, which are downregulated in many neurodegenerative diseases. Many HDACs are in development for use in cancer (>100 active clinical trials), but, despite solid data showing a potential benefit in halting cognitive decline, the use in central nervous system disorders is rare (only 5 in clinical trials). A major challenge is achieving sufficient brain permeation without inducing systemic toxicity. Medibiofarma has used its extensive knowledge of structure-based drug design to overcome this barrier and deliver its first lead compound MBF-015, which shows excellent brain permeation in animals and humans. MBF-015 has shown proof-of-concept safety and efficacy in animals, as well as in a Phase I clinical study, while a small Phase IIa study is currently ongoing. Within the Re-Spark project, Medibiofarma focusses on Huntington’s disease as first go-to-market indication, as this disease has a clearly defined target population and a high medical need. Medibiofarma requests €2.5M EIC Accelerator grant to extend the Phase IIa study and prepare a full asset package for Phase IIb, allowing the company to reach its next value inflection point. Hereafter, €30M equity is needed for running the Phase IIb trial to show clinical efficacy and enable closing of a licensing deal with a large pharma company. Medibiofarma requests €15M equity from EIC and plans to raise private financing in the form of a series A of €15M to complement the costs for the trials. Without EIC support, Medibiofarma will be unable to progress to the next development steps for MBF-015, substantially delaying potential health benefits for patients globally who are in need of effective therapies to halt cognitive decline.

Keywords: histone deacetylase inhibitor,synaptogenesis,cognitive decline,huntington s,small molecule
X-Verter®: Cell-level Controlled Battery System enabling software defined power (X-Verter)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

To meet the goal of limiting global warming to below 2°C, energy storage capacity must increase from 140 GW in 2014 to 450 GW by 2050. Currently, only 3–4 percent of globally generated electricity is stored by utilities. Hydrogen fuel cells, while suitable for centralized and long-term storage, involve multiple conversion steps and infrastructure challenges. Battery Energy Storage Systems (BESS) are often more efficient, especially for short-duration energy storage. However, conventional BESS systems face limitations such as high conversion losses, fixed-string cell connections leading to premature battery failure, and limited scalability. BLIXT's X-Verter® addresses these challenges with software-defined power conversion based on cell-level control technology. This innovation enables BESS to generate AC sine waves directly from the battery pack, significantly reducing energy losses, bypassing weak cells, and extending battery lifespan by up to 80%. The technology is adaptable to all battery chemistries, suitable for various applications, including second-life batteries, Li-ion, supercapacitors, and more. The modular and scalable design caters to diverse capacities and customer needs, from critical infrastructure backup power to grid-scale applications. The project aims to optimize the prototype design, control software, and produce/test the BESS. Compliance and certifications for various applications will be obtained, and an initial software platform for end-users and stakeholders will be developed. Stakeholder feedback during BESS demonstrations and field trials will inform further optimization and lead to large-scale commercialization. Strong letters of support from key stakeholders validate interest in supporting the project and beyond. BLIXT's strengths lie in its motivated founders and team, a proven track record of delivering disruptive innovations, a robust IP portfolio, and recognition from industry metrics and partners.

Keywords: battery energy storage,power electronics,energy efficiency,modular multilevel converters,power conversion,cell level control,semi conductors,software defined power,battery management
ALMA - Pioneering Smart Lens to Revolutionize Eye Care (ALMA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Nearly 5Mn people in the EU5, the UK, and the US are affected by irregular corneas, a condition characterized by imperfections on the corneal surface. Irregular corneas disrupt the smooth, regular structure needed to focus light evenly onto the retina, leading to distorted or blurry vision. This condition can result from various causes, including diseases, injuries, or previous surgeries. Patients with irregular corneas often experience significant visual disturbances and may struggle with glare, halos, and night vision issues. Treatment options range from spectacles and various contact lenses to more invasive procedures like corneal transplants. The current state-of-the-art solutions, including rigid scleral lenses, often fail to fully address high-order aberrations, leaving patients with persistent vision problems. After 9 years of research and breakthroughs in smart contact lens design, construction, and operation, Azalea has developed ALMA, the first patented autonomous and adaptable Smart Lens for patients with irregular corneas. This revolutionary solution integrates advanced light management technology into a scleral lens platform, featuring a dynamic light filter, a custom microchip, and a wireless base station for charging and disinfection. ALMA provides improved visual quality, enhanced comfort, and real-time adaptation to environmental conditions, offering a new standard of care for patients with irregular corneas. With EIC’s support, Azalea plans to conduct First-in-Human and pivotal clinical trials to obtain CE mark and FDA approvals for the commercialization of the ALMA Smart Lens. Our initial focus is on the irregular cornea market across Europe, the UK, and the US. This market encompasses a total addressable population of 614k patients with irregular corneas, representing a market opportunity of €3.7Bn. The project is expected to significantly impact Azalea, projecting €145Mn in revenues and reaching 100 employees within 5 years of commercialization.

Keywords: liquid crystals,autonomous diameter adaptation,smart contact lens,irregular cornea,active light management,vision correction,keratoconus,mems,visual optics,solid state microbattery
innovative Quality Of Experience maNagement in Emerging mulTimedia services (QoE-Net)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Italy,Norway,Korea, Republic of,Switzerland,Switzerland,Hungary,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2883122.64
EU funding (EUR): 2883122.64
Participants: 10
Project status: CLOSED

The realization of the paradigm of Internet anywhere, anytime and any-device and the diffusion of end-user multimedia devices with powerful and user-friendly capabilities such as smartphones, tablets PCs, mobile gaming terminals and e-books, are leading to the proliferation of a significant amount of emerging multimedia services: immersive environments, mobile online gaming, 3D virtual world, book/newspaper consumption, social networking, IPTV applications, just to cite a few. Some of these services have already reached a major market success, such as the case of newspaper/magazine mobile readers and smartphone multimedia apps. Their success has been achieved especially because a user-centered approach has been followed to design the whole process of content production, service activation, content consumption, service management and updating. From these considerations it arises that management of the Quality of Experience (QoE) is undoubtedly a crucial concept in the deployment of future successful services and it is straightforward to be understood but complex to be implemented in real systems, since there are many variables which will affect QoE, and these variables are changeable and span multidisciplinary areas including multimedia signal processing, communications, computer networking, psychology and sociology. This Network focuses on the analysis, design, optimization and management of the QoE in advanced multimedia services, creating a fully-integrated and multi-disciplinary network of 12 ESRs working in and seconded by 7 academic institutions, 3 private companies and 1 standardization institute distributed in 6 European countries and in Korea. This Network will offer to a group of newly recruited Fellows in a cross-sectoral environment to shape their long-term research view and get fundamental methodological tools on various research fields, namely: multimedia networking, signal processing, communications, business, psychology and sociology.

Keywords: quality of experience,multimedia services,user quality perception,qoe oriented network management
Bio-conjugatable and Bio-responsive Near Infrared Fluorochromes (NIR-BIO-FLU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, the optimisation of preclinical and clinical tests for new medication and act as a real-time guide during surgery. This proposal seeks support for a MSC Fellowship to develop new biologically responsive off to on switchable NIR fluorochromes i.e. NIR fluorescent probes that respond selectively to cellular uptake and with specificity for cancer cells achieved through bio-conjugation with proven targeting agents. Specifically, the focus is on the design, synthesis, photophysical characterisation, in vitro cell imaging and preliminary in vivo assessment of such probes for the ultimate in vivo detection of colorectal cancer metastasis. Colorectal cancer is the third most common cancer and remains a major public health issue in Europe because of its high prevalence, morbidity, and mortality. The synergetic combination of the host laboratory’s interdisciplinary expertise, the host institution’s ability to deliver a comprehensive training program and the applicant’s excellent prior Ph.D. training experience in developing fluorescence chromophores with function-tailored photophysical properties is the perfect match to deliver the project goals and provide the stepping stone to independent researcher for the applicant.

Keywords: azabodipy,near infrared,fluorescence,bio conjugation,imaging,colon cancer
Common Services (PJ15 COSER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Ireland,Italy,Italy,Spain,Italy,Switzerland,Belgium,Croatia,Hungary,Romania,Sweden,Belgium,France,France,Czechia,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Common Services (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 9259834.07
EU funding (EUR): 5037930.87
Participants: 29
Project status: CLOSED

The legacy of Air Traffic Management (ATM) evolution in Europe has resulted in today’s highly fragmented, country-based, services. A consequence of this fragmentation, there is a negative impact on the cost in the provision of ATM service in Europe. A fundamental goal of the Single European Sky initiative is to “provide ATM services to airspace users at a cost of at least 50 % less”. The notion of Common Service aims to contribute to this goal. Common Services, defined as “a service that provides capability to consumers in the same way that they would otherwise need to provide themselves”, aims to mitigate this issue. Common Service approach follows a general principle within the Single European Sky initiative that encourages the harmonisation on the provision of common air navigation services wherever it is possible. The main benefit of this approach is to deliver enhanced cost effectiveness to both the providing and consuming organisations and this could in turn potentially benefit the whole chain in the European air transportation business, making it more attractive as means of transport. Additionally, there could be a positive impact on other ATM performance areas as well, such as capacity, safety, flight efficiency, etc. The providing organisations would benefit from economy of scale, while the consumers would not need to maintain and update proprietary solutions anymore. Overall, a better rationalisation of deployment should be expected. Therefore this Common Service approach, if it is proved to be successful, could be viewed as an essential means to improve the overall cost effectiveness of the ATM business in Europe. PJ15 encompasses air navigation service providers and ground industry covering both provider and consumer perspectives. Thanks to its unique combination of operational and technical knowledge and experience, the group is in an excellent position to deliver high-quality results.

Keywords: common services interfaces harmonize fragmentation standard soa architecture swim business model dcb xman trajectory aeronautical virtual centre provider consumer
Greek Identity in Art Music since the Early Nineteenth Century: Towards an Interdisciplinary Methodology (GRIDAMUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-10
End date: 2020-01-09
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project is the first large-scale, interdisciplinary attempt to study mechanisms of national identity construction through modern Greek (post-1830) art music. It has two primary objectives: a) to develop an interdisciplinary methodological framework for the analysis of Greek art music drawing on historical musicology, Modern Greek Studies and ethnomusicology; and b) to offer a revisionist study of Greek art music – a repertory that remains to be investigated in the depth it merits – by exploring the ways in which it has mediated Greek identity during the period since the formation of the Greek nation-state in the early 19th century. Traditionally, the issue of “Greekness” – a perceived national character or identity – in music has been analysed with respect to the question of the assumed “continuity” of Greek history and culture since antiquity, as well as a quest for authenticity, purity, loyalty and uniqueness. Yet, such treatment of national identity is essentialising and self-exoticising. Recent scholarship on Greek music is starting to recognise the usefulness of contemporary methods of historical and cultural contextualisation. These approaches have much to gain from dialogue with a) recent critical discourses developed to understand and contextualise the concept of “Greekness” within modern Greek studies and b) ethnomusicological approaches to the study of music and identity. This project will equip me to become the first specialist on Greek art music to use an interdisciplinary methodology for the analysis of this music that draws on historical musicology, modern Greek studies and ethnomusicology, a method that has the potential to become paradigmatic for the study of other national repertories too and useful for other disciplines. The research will exploit archival sources while also drawing upon ethnographical methods. The outcomes will be: 1) a monograph, 2) two conference papers, 3) a series of public lectures and 4) a seminar series.

Keywords: greek art music,national identity,music studies,historical musicology,modern greek studies,ethnomusicology,interdisciplinarity,outreach
Participatory Pathways for Reshoring European Manufacturing (RESHORE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

RESHORE is an action research project which will investigate the potential and limits for manufacturing in Europe as part of a social economy fit for the future. In spite of decades of offshoring and a global race-to-the-bottom, manufacturing remains a significant part of the European economy, employing around 30 million people. Given increasing evidence of the vulnerabilities and unsustainabilities resulting from over-reliance on global supply chains, especially in a post-Covid context, RESHORE will enhance our understanding of how emerging and established European manufacturers operate and thrive, influencing discourse on sustainable economic transformation in the EU. Theoretically and methodologically grounded in economic geography, the project will take a comparative approach to learn from existing initiatives in reshoring manufacturing in Germany, Italy and the Czech Republic. The objectives of RESHORE are: 1. To advance a ‘diverse economies’ analytical framework for understanding the equitable relocalisation of European manufacturing; 2. To outline participatory pathways for local manufacturing in three EU Member States, drawing from interactive visioning workshops; 3. To identify the geographical influences for equitable reshoring transitions through empirical case studies. To achieve these objectives, and influence public debate on issues relating to reshoring, the project will combine conventional qualitative methods (ethnography, semi-structured interviews) with transdisciplinary, action-research approaches. A structured and comprehensive plan for training in transdisciplinary methods will enable the fellow to reach professional maturity and secure a group leader or permanent faculty position at a world-leading European research institution. This project will be hosted at LMU, Munich, and includes a secondment at the European Research Institute on Cooperative and Social Enterprise (EURICSE), Italy.

Keywords: social enterprise,solidarity economy,just transitions,geography,degrowth,production,ecological economics,community economies,qualitative,action research,participatory,transdisciplinary