Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Interpreting the SHH signal: real-time monitoring of the dynamic regulation of GLI3. (SHH PATHWAY SENSOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The SHH morphogenetic pathway exerts multiple functions during embryonic and adult life. It is involved in various cellular contexts to provide positional information, but also controls cell survival, proliferation and differentiation. Aberrant activation of the pathway has also been linked to tumour formation and growth. The SHH signal is integrated by receiving cells via the GLI transcription factors, which regulate the expression of SHH target genes. In particular, the GLI3 protein is processed into a repressor (GLI3R) form in the absence of SHH, while is converted into a transcriptional activator (GLI3A) upon exposure to SHH. SHH being a secreted factor, it is thought to establish a dual GLI3R:GLI3A gradient, with high levels of the GLI3R away from the source and high GLI3A close to the SHH-expressing cells. This mechanism permits various levels of activation of the pathway, depending on the GLI3R:GLI3A ratio. Despite the initial description of many pathway target genes, the primary response to variable SHH doses over time, and the subsequent alterations in GLI3R:GLI3A isoform ratios, are poorly understood. We have manipulated the Gli3 locus in mouse ES cells by RMCE to introduce a FLAG-tag into the endogenous protein. We have evidence that this FLAG-tagged GLI3 creates a sensor of the SHH signal (GLI3A-FLAG). We will use neuralized embryoid bodies and the knock-in mouse line derived from GLI3A-FLAG ES cells to monitor the cellular and molecular dynamics of GLI3A in sensing SHH activity. This system will permit us to track the relative occupancy of the promoter/regulatory elements of SHH target genes by GLI3, allowing a real-time readout of the way cells respond to SHH over time. Moreover, we will be able to visualize and study the postulated Gli3A gradient in vivo. Funding from the ERG program, together with the long-term contract I have been offered, would be a significant asset in establishing myself as an independent reseacher.

Keywords: developmental biology,patterning,limb development,neural tube development,sonic hedgehog,gli3,cell signaling,transcriptional regulation,recombinase-mediated cassette exchange (rmce)
Large Scale Production, Cloning, Chemical Functionalization and Materials Applications of Graphene (GRAPHENOCHEM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Germany
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-02-01
End date: 2015-01-31
Duration (months): 60.0
Total project cost (EUR): 1436400.0
EU funding (EUR): 1436400.0
Participants: 1
Project status: CLOSED

We propose the development of modern wet chemical concepts for the mass production and chemical modification of graphene - a rapidly rising star on the horizon of materials science - opening the door for superior but still elusive applications such as transparent electrodes, field effect transistors, solar cells, gas sensors and polymer enforcement. Owing to its spectacular electronic properties graphene is expected to be the most promising candidate to replace classical Si-technology and no longer requires any further proof of its importance in terms of fundamental physics. However, fully exploiting the proposed applications requires the availability of processable graphene in large quantities, which generally has been considered to be an insurmountable challenge. This is where the GRAPHENOCHEM project sets in. Our laboratory has been pioneering and is at the forefront of carbon allotrope chemistry. After having investigated basic principles for the functionalization of the 0-dimensional fullerenes and the 1-dimensional carbon nanotubes, which lead to synthesis of numerous examples of derivatives with tailor made properties, we recently started successfully with the investigation of wet chemical approaches for the efficient production of graphene sheets using graphite as an inexpensive starting material. The strategy of GRAPHENOCHEM is to combine chemistry, nanotechnology and materials science to establish highly efficient protocols for the mass production of soluble graphene and the subsequent processing to a whole variety of thins films, composites and devices with outstanding properties. To our knowledge we are the first synthetic organic chemists facing this challenge. We propose to go through the following sequential key objectives, namely: Development of efficient protocols for the mass production of soluble single layer graphene, cloning of graphene, chemical functionalization and doping of graphene, and engineering of graphene based materials and devices.

Keywords: graphene,molecular electronic,detergents,solas cells,gas sensor,polymer enforcement
Dynamic Mechanism Design: Theory and Applications (DMD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: Germany
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2016-04-30
Duration (months): 72.0
Total project cost (EUR): 1123200.0
EU funding (EUR): 1123200.0
Participants: 1
Project status: CLOSED

We plan to construct a theoretical bridge between classical dynamic allocation models used in Operations Research/Management Science, and between the modern theory of mechanism design. Our theoretical results will generate insights for the construction of applied pricing schemes and testable implications about the pattern of observed prices. The Economics literature has focused on information and incentive issues in static models, whereas the Operations Research/Management Science literature has looked at dynamic models that were often lacking strategic/ informational aspects. There is an increased recent interest in combining these bodies of knowledge, spurred by studies of yield management, and of decentralized platforms for interaction/ communication among agents. A general mechanism design analysis starts with the characterization of all dynamically implementable allocation policies. Variational arguments can be used then to characterize optimal policies. The research will focus on models with multidimensional incomplete information, such as: 1) Add incomplete information to the dynamic &amp; stochastic knapsack problem; 2) Allow for strategic purchase time in dynamic pricing models; 3)Allow for competing mechanism designers. The ensuing control problems are often not standard and require special tools. An additional attack line will be devoted to models that combine design with learning about the environment. The information revealed by an agent affects then both the value of the current allocation, and the option value of future allocations. We plan to: 1) Derive the properties of learning processes that allow efficient, dynamic implementation; 2) Characterize second-best mechanism in cases where adaptive learning and efficiency are not compatible with each other.

Keywords: dynamic mechanism design,revenue management
Deterministic Logical Photon-Photon Interactions (DELPHI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-01-01
End date: 2014-12-31
Duration (months): 60.0
Total project cost (EUR): 2496000.0
EU funding (EUR): 2496000.0
Participants: 1
Project status: CLOSED

The main objective of this proposal is to design and implement a novel scheme for efficient, deterministic, lossless photon-photon interactions, and to exploit it to achieve logical processing and quantum measurements on optical light beams. For that purpose, we will create, study and exploit a new transparent medium, based on the transient excitation of Rydberg polaritons, where the optical non-linearities are so large that they can act at the single photon level. These techniques will be applied to perform quantum measurements and manipulations of light beams. This will include the deterministic generation of single photons and optical Schrödinger's cat states, the implementation of quantum non-demolition (QND) measurements for the photon number and the parity operators, and the demonstration of controlled-phase and controlled-not quantum gates. These operations will be implemented in the optical domain, where they can be combined with efficient propagation in free space or in optical fibers, and with high efficiency detectors already available, in order to open an avenue towards a fully deterministic quantum engineering of light.
Open Access Infrastructure for Research in Europe (OPENAIRE)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Greece,Germany,Italy,Netherlands,United Kingdom,Germany,Poland,Portugal,Switzerland,Belgium,Spain,Denmark,Germany,Germany,Italy,Cyprus,Lithuania,Sweden,Bulgaria,Hungary,Ireland,Czechia,Finland,Germany,Norway,Slovenia,France,Austria,Estonia,Latvia,Malta,Slovakia,Romania
Call:  (FP7-INFRASTRUCTURES-2009-1, 2009)
Start date: 2009-12-01
End date: 2012-11-30
Duration (months): 36.0
Total project cost (EUR): 5027379.0
EU funding (EUR): 4169927.0
Participants: 39
Project status: CLOSED

The proposed project will deliver “an electronic infrastructure and supporting mechanisms for the identification, deposition, access, and monitoring of FP7 and ERC funded articles”, where the main supporting mechanism will be the establishment and operation of the European Helpdesk System. Additionally, the project will offer “a special repository for articles that can be stored neither in institutional nor in subject-based/thematic repositories”, while it will also prepare the way for similar functionality on scientific data. All deposited articles and data will be freely accessible worldwide through a new portal to the products of EU-funded research, built as part of this project. It will also connect research input (project contracts) with research output (publications and data) and monitor the system use to obtain statistically-significant trends about both. Thematically, the project will focus on peer-reviewed publications (primarily, journal articles in final or pre-print form, but also conference articles, when considered important) in at least the seven disciplines highlighted in the Open Access pilot (energy, environment, health, cognitive systems-interaction-robotics, electronic infrastructures, science in society, and socioeconomic sciences-humanities) and on research datasets in a subset of them. Geographically, however, it will have a definitive “European footprint” by covering the European Union in its entirety, engaging people and scientific repositories in almost all 27 member states and beyond. The electronic infrastructure built by the project will be based on state-of-the-art software services of the D-NET package developed within the DRIVER and DRIVER-II projects and the Invenio digital repository software developed at CERN. These will be further enhanced and complemented with services developed within OpenAIRE to address critical requirements and issues that arise in the target environment and require further investigation.

Keywords: open access,electronic infrastructure
Protein design to generate bio-functional nanostructures (BIONANOTOOLS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The main objective of my research project is to understand how the structure and function of proteins are defined by their sequence and to apply learned rules to design new protein-based nanotools. In particular, I will focus on a type of proteins called tetratricopeptide repeats (TPR). They present a simple modular structure, where a small structural unit is repeated in tandem. Overall TPR domains are a very robust system to study protein structure, folding, and function, and to use them as building blocks for protein engineering to generate new functional nano-molecules. I aim to study natural TPR domains that mediate protein-protein interactions at a molecular level, and extract basic principles that govern these interactions to apply them in the design of TPR units with desired specific activities. I will also perform basic studies on protein stability and folding of designed TPRs to gain a better understanding on how the protein sequence determines thermodynamic stability. These studies will allow us to generate more stable proteins that will be useful in biotechnological applications, such as generation of novel biomaterials. The ability to discriminate between residues that determine the structure and stability, from those responsible of the binding specificity in the protein scaffolds, together with the capacity to generate super-stable scaffolds, opens the door to the generation of protein libraries. In such libraries only the binding sites will be randomized in order to incorporate a wide variety of potential specificities, and will be screened against different targets of interest using high-throughput methods. We will design functional proteins with defined binding-specificities and structural properties. These novel bio-tools will be extremely useful to monitor and investigate biological processes in vivo, as biosensors for diagnosis to detect disease biomarkers, and also as building blocks for applications in biomaterials design.

Keywords: protein design,functional nanomolecules,biosensors,protein libraries,nanobiology,protein-protein interation,protein stability
Distributed Research Infrastructure for Hydro-Meteorology Study (DRIHMS)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Italy,Germany,Germany,Italy
Call:  (FP7-INFRASTRUCTURES-2009-1, 2009)
Start date: 2009-11-01
End date: 2011-04-30
Duration (months): 18.0
Total project cost (EUR): 320924.0
EU funding (EUR): 250000.0
Participants: 4
Project status: CLOSED

In the Lisbon strategy, the 2005 European Council identified knowledge and innovation as the engines of sustainable growth and stated that it is essential to build a fully inclusive information society. In parallel, the World Conference on Disaster Reduction (Hyogo, 2005), defined among its thematic priorities the improvement of international cooperation in hydrometeorology research activities. Hydrometeorological science has made strong progress over the last decade at the European and worldwide level: new modelling tools, post processing methodologies and observational data are available. In principle, a huge amount of hydrometeorological data and information is available for the European region, but enormous scientific and technical obstacles have to be overcome when mining the data. Recent European efforts in developing a platform for e-science, like EGEE (Enabling Grids for E-sciencE), SEE-GRID-SCI (South East Europe -GRID e-Infrastructure for regional e-Science), and the German C3-Grid, provide an ideal basis for the sharing of complex hydrometeorological data sets and tools. Despite these early initiatives, however, the awareness of the potential of the Grid technology as a catalyst for future hydrometeorological research is still low and both the adoption and the exploitation have astonishingly been slow, not only within individual EC member states, but also on a European scale. With this background in mind, the goal of the Distributed Research Infrastructure for Hydro-Meteorology Study (DRIHMS) project is the promotion of the Grid culture within the European hydrometeorological research community through the diffusion of a Grid platform for e-collaboration in this earth science sector: the idea is to further boost European research excellence and competitiveness in the fields of hydrometeorological research and Grid research by bridging the gaps between these two scientific communities.

Keywords: hydrometeorology,grid,e-science,collaborative research,cross-fertilization,e-infrastructure
HPCWorld (HPCW)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,France
Call:  (FP7-INFRASTRUCTURES-2009-1, 2009)
Start date: 2009-11-01
End date: 2012-04-30
Duration (months): 30.0
Total project cost (EUR): 449960.0
EU funding (EUR): 250000.0
Participants: 4
Project status: CLOSED

Among e-Infrastructures, ESFRI has identified in FP7 High Performance Computing a strategic priority for Europe. The cost of the related RI is steadily increasing as well, insomuch as, today, the most advanced computing facilities can be conceived only on trans-national or even continental basis, with a joint contribution of a number of different member states. A paradigmatic example is represented by PRACE. In order to have the highest return from such massive economical and political commitment, HPC resources must be exploited at the highest level. Their access must be effective and capillary, their services must allow more and more people to use the resources. Homogeneous and effective selection and evaluation procedures for HPC users and related research projects must be defined, to guarantee the excellence of the scientific objectives and the suitability to international research programs and main scientific development streamlines. Cooperation and coordination between the HPC stakeholders is necessary to define the path-forward to the next generation of computing services. HPC-World will address these issues, with the objective of identifying a standard set of criteria and procedures and an associated methodology to drive the largest HPC e-Infrastructure initiatives in the deployment of services, in the allocation of resources and in the support to users’access. In particular, the project will model its activities and outcomes on PRACE, in order to offer a mature and effective methodology, to manage its access activities and resources allocation procedures, providing the instrument to deploy and exploit promptly, and with tuned policies and strategies, the available infrastructures. The involvement of non-European partners will strongly improve and enrich, the outcomes of the project and strengthen the international cooperation between the European HPC RI and similar RIs from other regions, promoting synergies beyond the continental boundaries.

Keywords: access,reviewing,selection,model,good-practice,high performance computing,research infrastructure,interoperability,international cooperation.
A translational approach evaluating novel strategies using chemotherapy to enhance immune-mediated anti-tumor activity (CHEMO-IMMUNE THERAPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A wealth of successful pre-clinical immunotherapy-based treatment protocols against cancer have been documented, yet only a limited number of clinical trials have proven to be successful. A common consensus among clinical and bench-side researchers is that a combination of several treatment modalities should be used to achieve complete tumor regression. In recent years, evidence that chemotherapy agents can be used to enhance immune-based therapies has emerged. The specific aims described below are designed to evaluate novel treatment modalities against cancer using chemotherapy agents that have the ability to sensitize tumors to both innate and adaptive anti-tumor immune responses. 1. Examine the effect of different chemotherapy agents in their ability to modify tumor susceptibility to autologous and allogeneic natural killer (NK) and T cell -mediated apoptosis in vitro. 2. In vivo confirmation and evaluation of selected agents in murine syngeneic and allogeneic hematopoietic stem cell transplantation (HCT) tumor models. The results of these studies will lay a foundation for NK cell-based and T cell-based therapies which could lead to more effective treatments for cancer patients. In addition to defining mechanisms how the various chemotherapy agents may influence NK or T cell anti-tumor responses, several subsidiary projects derived from this research will most likely develop.

Keywords: immunology,anticancer therapy,medicine