Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using the precision mouse genetic tool MADM to elucidate the role of EGFR in directing beta cell differentiation and pancreatic morphogenesis (MADMpancreas)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Insulin producing beta cells are derived from bipotent pancreatic progenitors (bi-PPs) that constitute the primitive ductal epithelium. While we now know a great deal about the transcriptional networks required for endocrinogenesis and commitment to the beta lineage, considerably less is understood about the cellular events that initiate delamination and activate differentiation networks. The host group recently found that ligand-specific Egfr signaling is essential for these processes. Signaling by the highly potent Egfr ligand betacellulin diminishes apicobasal polarity leading to upregulation of Ngn3, delamination, and beta cell differentiation. The overall aim of this proposal is to elucidate the role of Egfr signaling in the beta cell differentiation process. I will ask: Is the seemingly stochastic differentiation of bi-PPs regulated by inherent differential Egfr signaling? Do quantitative differences in this single pathway lead to different cellular outcomes? How does the targeted loss of Egfr in Ngn3-expressing endocrine precursors affect their differentiation? What are the genes regulated by Egfr pathway activation that putatively commit Ngn3+ progenitors to a beta cell fate? And how does the disruption of endocrine differentiation affect ductal morphogenesis? Answers to these questions have remained elusive because of the difficulty of observing individual cell behaviors in situ in the developing pancreas. To meet this challenge, I will adapt the cutting edge mouse genetic tool Mosaic Analysis with Double Markers (MADM) to quantitatively manipulate Egfr levels in bi-PPs and to concomitantly label altered cells. The successful implementation of MADMouse will deliver findings of immediate interest to investigators seeking to improve the directed differentiation of therapeutic grade beta cells from hPSCs. I will augment my expertise in precision mouse genetics with training in hESC culture enhancing my career goal of establishing my own research group.

Keywords: beta cells,egfr,pancreas,morphogenesis,tubulogenesis,directed differentiation,diabetes,madm
A multi-stakeholder Regional Action Network as a living structural base to effectively help define and implement deep energy efficient building renovation at local, national and European level. (BUILD UPON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Spain,Türkiye,Bulgaria,Finland,Croatia,Slovakia,Slovenia,Sweden,Romania,Latvia,Czechia,United Kingdom
Call: Empowering stakeholders to assist public authorities in the definition and implementation of sustainable energy policies and measures (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 2351567.5
EU funding (EUR): 2351563.0
Participants: 14
Project status: CLOSED

BUILD UPON: Empower stakeholders to assist public authorities. 1. Provide large-scale capacity building or engagement activities: The key objective is to engage and empower a ‘critical mass’ of over 1,000 stakeholders with the process of defining and implementing their long-term national renovation strategy (Article 4, Energy Efficiency Directive). Process carried out by an important organisational innovation, ‘Green Building Councils’ (GBCs), in BG,CZ,ES, HR, IT, IE, FI, LV, RO, SE, SI, SK and TR. GBCs are multi-stakeholder platforms, formalising a ‘Regional Action Network’ of connected actors who will ensure the continuation of the activities beyond the project’s duration. 2. Target specific actors among a wide spectrum of stakeholders: The renovation stakeholder ecosystem will be mapped across the Project countries, to understand precisely which organisations will be needed to define and implement Article 4 and how this system functions. BUILD UPON has received over 100 letters of support across all its target groups. 3. Demonstrate a strong European added value: The complex landscape of renovation initiatives (both public policy and market driven) will be compressed in a living ‘RenoWiki’ resource, to enable stakeholder understanding and dialogue, and ensure all stakeholders are ‘on the same page’. The stakeholder ‘community’ will be developed through a series of nearly 80 workshops across the region at local, national and European level. These will explore collaborative and solution focused working methods to deliver the stakeholder buy-in required by government to define and implement ambitious and viable Article 4 strategies. Experts involved with the design and management of identified best practice renovation initiatives will help stakeholders assess feasibility for implementing these in other countries, to move best practice sharing beyond information to action, and an incubator for new concepts will help launch further implementation orientated projects.

Keywords: multi stakeholder collaboration,policy making,collaborative decision making,national renovation strategies,green building councils,global,regional action network
Fascinating World of Researchers in the Age of Technology 2016/2017 - The New Generation of Innovators (FAWORIT 2016-2017)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Hungary
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-04-01
End date: 2017-11-30
Duration (months): 20.0
Total project cost (EUR): 207675.0
EU funding (EUR): 207675.0
Participants: 4
Project status: CLOSED

The main objective of our FAWORIT proposal is twofold: 1) to show the public how researchers with their innovative solutions affect our daily lives; 2) to encourage the youth – with a special focus on girls – to embark on scientific careers by involving young innovators in our programmes. Our main target group is students between the age of 8-20, but we aim to address all age groups with attractive programmes. Some novelties of our project: offering challenge-oriented activities – each of our 18 venues will present their innovative solutions related to interdisciplinary societal challenges; focussing on the concept of Responsible Research and Innovation - the audience will be informed about key elements of RRI, thus creating better understanding and fostering future involvement; launching “Science in the City” – a flash mob like activity, involving the public in spectacular experiments. We will apply an integrated approach in our project in which interdisciplinary challenges, innovative solutions, (young) researchers, their work and hobbies will be presented in an interactive, educating and entertaining way. The target audience can thus discover that being a researcher is cool and creative; researchers, but and young innovators are amongst us. Our objective is to have around 30000 visitors at the events, but a multiple of that number (around 500000) will see, hear or read about the Night. We intend to raise awareness of the European engagement in R&I; in the European Corners and at each venue related programmes of the European Union (FP7, H2020, especially MSCA) will be visible. The structure of the consortium: an innovative SME, a state-owned applied research institution, a highly innovative large company, a scientific association with a broad network of local member institutions all over Hungary and an independent think tank established by economists and sociologists together with numerous contributing partners of all kinds will ensure the success of the project.

Keywords: public recognition,young innovators,responsible research and innovation,societal challenges,women in science,edutainment,innovative products,services,attractiveness of researchers career,media
Commercialization of catalytic enhancers targeting IDO1 for multiple sclerosis (ENHANCIDO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

ENHANCIDO will assess the commercial and technical feasibility of novel immune tolerance-inducing small molecules as superior treatments for multiple sclerosis (MS). MS is a chronic neurodegenerative disease affecting 2.3 million people worldwide. 85% of MS cases belong to the relapsing-remitting subtype (RRMS) characterised by bouts of recurring and debilitating relapses followed by unstoppable loss of neurological functions. Unfortunately, current treatments for RRMS are ineffective, poorly tolerated, and expensive. They cannot prevent disease progression and only provide symptomatic relief. Furthermore, severe adverse effects and inconvenient administration routes contribute to high rates of treatment discontinuation amongst patients (30-80%). To tackle these issues, Prof. Ursula Grohmann has developed a set of novel, orally administered, effective, and safe small molecules that induce immune tolerance to alter the previously inexorable course of the disease. These first-in-class molecules are positive allosteric modulators (PAMs) of the immunoregulatory enzyme IDO1. Prof. Grohmann’s PAMs increase IDO1 activity, reduce disease severity in mouse models of acute MS and show no off-target effects. Within ENHANCIDO, we will assess whether IDO1 PAMs are feasible as breakthrough treatments for RRMS. Firstly, we will validate their technical feasibility by evaluating their efficacy, pharmacokinetics and pharmacodynamics in RRMS mouse models. Subsequently, commercial feasibility will be determined by verifying IP position and strategy, performing in-depth market and competitor analyses, and finally consolidating these into a business plan to establish the best path to commercialisation. Successful commercialisation of IDO1 PAMs could reduce the profound socioeconomic burden of MS, extend and improve the lives of patients, and provide the pharmaceutical industry with a profitable, first-in-kind drug that can potentially be used for other autoimmune diseases.

Keywords: multiple sclerosis,allosteric modulators,immune tolerance,autoimmune disease
Cytoplasmic sensing of Toxoplasma gondii infection and host cell programmed necrosis (Toxoplasma sensing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-01-29
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

My goal is to understand how cell-autonomous immunity (CAI) can detect intracellular parasites such as Toxoplasma gondii in their membrane-bounded intracellular niches, how recognition induces necrosis of the host cell, and how host death signalling pathways contribute to inflammatory disorders. Although adaptive immunity ultimately contributes to host survival, the initial response is controlled by innate mechanisms. Mice rely primarily on IFNγ-induced CAI effectors virtually absent in humans, the immunity-related GTPases (IRGs). Parasitophorous vacuole (PV) membrane attack by IRGs results in parasite eviction and elimination, swiftly followed by regulated necrosis of the host cell. Preciously little is known about how parasite sensing drives cell death, particularly in (mouse and human) non-haematopoietic cells (NHCs) lacking the full antimicrobial arsenal of immune cells. Yet necrosis is key to limiting infection and driving parasite chronicity, while potentially eliciting immunopathology. I have 2 objectives: 1) the identification of the intracellular sensor(s) of T. gondii ligands and/or vacuole damage and 2) the dissection of the signalling pathway(s) leading to parasite/cell demise. Using a combination of genetic screens and cell biology tools, I will pinpoint PRR/necrosis genes involved. Elucidating these signalling pathways will help direct therapeutic interventions relevant for toxoplasmosis and inflammatory diseases. This proposal and accompanying career development plan, to be supervised by Prof. Jonathan C. Howard and hosted by the IGC, will be fostered by a dynamic research environment and crucial collaborations that will enable me to receive the necessary training and transferrable skills to establish my own lab. In turn, my extensive training in host-pathogen interactions will greatly benefit this project and the IGC, potentiating integration of knowledge/expertise.

Keywords: toxoplasma gondii,cell autonomous immunity,interferon gamma,vacuolar pathogen,vacuole rupture,pattern recognition receptor,programmed necrosis,regulated necrosis,inflammation,immunopathology
Diversity Enhancements for SIEMs (DiSIEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Spain,Germany,United Kingdom,Portugal,United Kingdom
Call: Information driven Cyber Security Management (H2020-DS-2015-1, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 4020018.75
EU funding (EUR): 3445875.75
Participants: 10
Project status: CLOSED

Security Information and Event Management (SIEM) systems are a fundamental component of the ubiquitous ICT infrastructures that form the backbone of our digital society. These systems are mostly used to monitor infrastructures using many types of sensors and tools and correlate the obtained events to discover possible threats (attacks, vulnerabilities, etc.) to the organization. The DiSIEM project aims to enhance existing SIEM systems with diversity-related technology. More specifically, we want to (1) enhance the quality of events collected using a diverse set of sensors and novel anomaly detectors, (2) add support for collecting infrastructure-related information from open-source intelligence data available on diverse sources from the internet, (3) create new ways for visualising the information collected in the SIEM and provide high-level security metrics and models for improving security-related decision project, and (4) allow the use of multiple storage clouds for secure long-term archival of the raw events feed to the SIEM. Given the high costs of deployment of SIEM infrastructures, all these enhancements will be developed in a SIEM-independent way, as extensions to currently available systems, and will be validated through the deployed in three large-scale production environments.
PREvention of STroke in Intracerebral haemorrhaGE survivors with Atrial Fibrillation (PRESTIGE-AF)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Spain,Belgium,France,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Comparing the effectiveness of existing healthcare interventions in the adult population (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2017-12-01
End date: 2024-11-30
Duration (months): 84.0
Total project cost (EUR): 6958896.0
EU funding (EUR): 6958896.0
Participants: 14
Project status: SIGNED

Intracerebral hemorrhage (ICH) is a severe stroke subtype causing higher mortality and more disability than other strokes. 20% of ICH survivors have atrial fibrillation (AF), a major cause of ischemic stroke (IS). While IS in AF patients is generally prevented by oral anticoagulants (OAC), their use in ICH survivors is uncertain due to increased bleeding risk. No evidence from randomized controlled trials (RCT) is available addressing this dilemma. Personalized risk prediction is desirable to balance benefits of OAC against bleeding risk for individualized prevention. Objectives: (1) To perform the first sufficiently powered RCT in ICH survivors with AF testing if direct OAC are superior for IS prevention and non-inferior regarding ICH recurrence versus antiplatelet or no antithrombotic therapy (2) To personalize antithrombotic prevention by multidimensional risk modeling (3) To estimate population impact of trial outputs on health economic consequences and generalizability to European population (4) To explore patient-centered aspects including adherence, attitudes towards antithrombotic therapy and gender imbalances in trial enrollment. Methods: Prospective, open RCT with blinded outcome assessment. Hierarchical sequential testing of co-primary endpoint IS and recurrent ICH. Sample size expected: 314-420 patients. RCT will recruit in 70 centers in 6 countries over 4-5 years with a mean 2-year follow-up (minimum 6 months, maximum 36 months). Clinical characteristics, MRI, blood-biomarkers and genetics will be characterized at baseline to model a new personalized risk prediction tool. Relevance for work program: PRESTIGE-AF addresses the unmet need of best antithrombotic stroke prevention in ICH patients with AF. Recurrent stroke reduces individual life expectancy, quality of life and has high public health impact. Work packages integrating biological data will generate new tools to tailor prevention. Modeling of economic and societal consequences and replication in real-life settings will estimate population impact.

Keywords: stroke,intracerebral haemorrhage,atrial fibrillation,ischaemic stroke,oral anticoagulants,antiplatelets,antithrombotics,personalised medicine,secondary prevention,public health
The unique high-performance biodegradable leather tanned with natural elements (NATURELLA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Santori Pellami was founded in 1890 and thanks to the experience gained from generation to generation, we are specialized in the production and sale of different leather products from veal, beef, pork, sheep among other. In the fashion and luxury sector in which we operate, the themes of sustainability, circular economy, respect for the environment have today assumed a centrality. Thus since 2015, we have been in search for more sustainable materials, and today we are the first companies to have experimented a method of tanning with the lowest level of heavy metals, and free from hexavalent Chromium. In April 2017, we have developed an innovative process to obtain a high-quality leather hides tanned using biodegradable, organic ingredients, with low use of heavy metals (Cadmium, Cobalt, Nickel and Lead) and without Chromium. Today, Naturella hides have been certified 77% biodegradable and compostable in controlled conditions according to ISO 14855 by University of Bologna. We have titled and registered the Naturella trade mark, and we can already offer this new leather to early clients. The aim of this project is to study the technical and economic feasibility of an innovative “short-chain” business model for Naturella leather in the main European markets, in particular in Italy, Portugal, Spain, Bulgaria, Germany and Serbia. A Life Cycle Assessment regarding the environmental impacts of our product will be done, and our overall objective is to plan the increase of our market share and the source of revenues through the development of the Naturella product. Our purpose is to increase in 3 years our revenues by 30%, guaranteeing a revenue share of at least 20% of our total turnover coming from Naturella. From the results of our phase 1 project we expect to be able to plan the activities to grasp the target sales and profit targets.

Keywords: biodegradable leather,metal free tanning process,sustainable fashion,short chain production
Secretariat of the European Technology and Innovation Platform on Renewable Heating and Cooling (SecRHC-ETIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to sectorial fora (H2020-LC-SC3-2018-Joint-Actions-3, 2018)
Start date: 2018-12-01
End date: 2022-05-31
Duration (months): 42.0
Total project cost (EUR): 984200.0
EU funding (EUR): 984200.0
Participants: 6
Project status: CLOSED

This proposal aims at supporting the work which has been carried out by the secretariat of the European Technology and Innovation Platform on Renewable Heating and Cooling since 2011. The role of the secretariat is to assist the stakeholders of the RHC-ETIP in coordinating activities related to the definition and implementation of an innovation strategy to increase the use of renewable energy sources for heating and cooling, and to foster the growth and the market uptake of the relevant industries. The secretariat provides support to the structure of the RHC-ETIP, by organising meetings, events, and relevant consultations, and by assisting with the preparation of relevant documents (both of technical and of political nature) to raise the profile and importance of the renewable heating and cooling sector, and its related technologies. This proposal also addresses the need to enlarge the membership of the RHC-ETIP by involving more closely national policy makers, as well as other relevant stakeholders (related industries, and socio-economic experts) in its work. By supporting interactions between several stakeholders representing industry, research and academia, from different renewable heating and cooling technologies, and by gradually including complementary sectors and expertise, the SecRHC-ETIP will assist the RHC sector in strengthening its growth and competitiveness both vis-à-vis traditional heating and cooling technologies, as well as with respect to competitors coming from non-EU countries.

Keywords: renewable heating and cooling,geothermal,solar thermal,biomass,heat pumps,district heating,thermal energy storage