Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular origins of aneuploidies in healthy and diseased human tissues (ANEUPLOIDY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Croatia,Netherlands,United States,Netherlands
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 9999750.0
EU funding (EUR): 9999750.0
Participants: 5
Project status: SIGNED

Chromosome segregation errors cause aneuploidy, a state of karyotype imbalance that accelerates tumor formation and impairs embryonic development. Even though mitotic errors have been studied extensively in cell cultures, the mechanisms generating various errors, their propagation and effects on genome integrity are not well understood. Moreover, very little is known about mitotic errors in complex tissues. The main goal of this project is to uncover the molecular origins of mitotic errors and their contribution to karyotype aberrations in healthy and diseased tissues. To achieve our goal, we have assembled an interdisciplinary team of experts in molecular and cell biology, cell biophysics, chromosomal instability in cancer, and theoretical physics. Our team will introduce novel approaches to study aneuploidy (superresolution microscopy, optogenetics, laser ablation, single cell karyotype sequencing) and apply them to state-of-the-art tissue cultures (mammalian organoids and tumoroids). In close collaboration, Tolić will establish assays to detect and quantify error types in cells, and Kops and Amon will use the assays on various healthy and cancer tissues. Tolić and Kops will uncover the molecular origins of errors, their propagation and impact on genome integrity, while Amon will lead the investigation of the mechanisms that ensure high chromosome segregation fidelity in healthy tissues. Interwoven in these collaborations are the efforts of Pavin, who will develop a theoretical model to describe the origin of errors and to quantitatively link chromosome segregation fidelity in single cells and tissues. Model and experiment will continuously inspire each other, to achieve deep understanding of how mitotic errors arise, how they propagate and how they impact on cell populations. Thus, the extensive sets of expertise present in our team will be combined and expanded with novel technologies to tackle the big challenge of the origins of aneuploidy in humans.

Keywords: chromosome segregation,aneuploidy,mitotic spindle,organoids,laser microsurgery,modeling
The inflammatory gene expression program in macrophages: An integrative approach for the systematic characterization of transcriptional co-regulators (MEDICI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-10-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 1377911.71
Participants: 2
Project status: CLOSED

Tissue responses to microbial and endogenous danger signals involve the activation of both resident and monocyte-derived macrophages, as well as the coordinated inducible expression of hundreds of inflammatory genes. Gene transcription is controlled by the information contained in thousands of genomic regulatory elements (enhancers and promoters), which is first read by transcription factors (TFs) and then integrated and relayed to the transcriptional machinery via an array of co-regulators with disparate biochemical activities and functions. The recent work of several groups, including our own, has extensively characterized how in macrophages the genomic regulatory sequences controlling inflammatory gene expression are coordinately bound and activated by myeloid lineage-determining TFs and broadly expressed stimulus-activated TFs. However, we still have a very incomplete understanding of the necessary next step in the process, namely how distinct combinations of DNA-bound TFs regulate recruitment and function of the co-regulators and machineries that control gene transcription. Here, I propose to systematically identify the complement of co-regulators that control the induction of inflammatory genes in macrophages, which will be then mechanistically and functionally characterized both in vitro and in vivo. By integrating cutting edge genomic and computational approaches with focused genetic screens and biochemical analyses, and eventually validating relevant results in mouse models, this project aims at obtaining an unprecedented level of understanding of the information flow linking genomic regulatory elements to inflammatory gene transcription.

Keywords: macrophages,transcription,transcription factors,chromatin,epigenetics and gene regulation
Innovative FUel Sensor for engIne OptimisatioN (I-Fusion)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The environmental emissions impact of transport is currently a major concern and has to be minimized at a world-wide level (Carbon footprint, NOx, Particulates, Soot). In order to meet the "20-20-20" targets, greenhouse gas emissions reduction in EU and improvement in the EU's energy efficiency has to be performed. To do so, one way to achieve this goal is to optimize fuel consumption by proposing technologies and practices. While there is huge variation in fuel compositions placed on the international market, car Engine Electronic Control Units (ECU) are built and calibrated with only one specific reference fuel. This universal calibration implies safety margins leading to penalties in terms of CO2 and other pollutant exhaust emissions in real conditions. I-FUSION project objective is to develop a Fuel Quality Sensing (FQS) technology, to be installed on-board vehicles equipped with thermal engines. This sensor will provide real-time information on fuel composition to the ECU, giving the opportunity to adapt all Engine actuators (injection, Exhaust Gas Recirculation…) in order to reduce both consumption and CO2 emissions by up to 5% and to reduce pollutant emissions by up to 20% at source. The project is leaded and composed by an innovative French SME, SP3H, which develops new technologies focused on the profiling of fuel molecular structure for the control and reduction of emissions of carbon dioxide and other pollutants. SP3H will conduct a feasibility study (phase 1) to prove the technical compatibility with the automotive application by an endurance test in operational environment (more than 100 000 km). Associated to the business data, the phase 1 will provide all the information necessary to the next phases.

Keywords: fuel quality,fuel quality sensing,engine electronic control unit,engine actuators,optimize pollutant,co2 emissions,engine behaviour optimization,automotive
Feasibility Study to Combat Physical Inactivity and Improve Sporting Skills through SCULT Sport Mentors and Coaches Marketplace (SCULTMARKET)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Estonia
Call: SME business model innovation (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

About 26% of European adults and 80% of adolescents do not engage in sufficient physical activity, leading to over 500 000 premature deaths per year and imposing annual economic costs of over €80 billion. Sport coaching and mentoring fulfills an important social function in educating, motivating and activating citizens to engage in physical activity. However, with current solutions the access for citizens to sport coaches and mentors is chaotic, whereas freelance sport mentors lack the ability to effectively provide and monetize their services. The overall objective of the innovation project is to develop and mainstream SCULTmarket, an interactive platform for “sculting”: facilitating the relationships, activities and service-monetization for sport mentors, coaches and their clients in a mutually benefitting technological, social and educative environment. SCULT Ltd. is the first to the market with a compelling business case to effectively combat physical inactivity in Europe and beyond thanks to its scalable nature and business model based on the logic of on-demand service and sharing economy. The prototype has been validated by an extensive mix of experts and potential users within the SCULT network of about 10 000 people through tests conducted at various sport events and activities. SCULTmarket will attract 250 000 users and 130 000 monthly Mentorship Sessions by the end of 2017, and is foreseen generate an annual turnover of €149 million by 2020. The specific objective of SCULTMARKET project is to verify the business model from the practical, social, technological and economic point of view. The expected outcome is a detailed business, scaling and brand strategy for commercializing the proposed SCULTmarket application, including an IP strategy. Technical requirements and product development roadmap for the application and associated infrastructure will be documented to feed into Phase 2 of the innovation project.

Keywords: social innovation,social enterprise,sport coaching and mentoring,service monetization
Feasibility study for Multicursor - a non-contact sensor for curing quality control (Multicursor)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Lithuania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Although manufacturing is moving towards digitalization and full automation, some industries, such as the furniture industry, are still heavily reliant on inefficient and outdated technologies. In particular, the furniture sector has been identified to lack any sort of automated solution for wood curing quality control, one of the critical manufacturing processes. Apart from causing a high defect rate, the absence of an inspection system creates a risk of manufacturing hundreds of thousands of pieces of furniture that are not adequately cured and potentially poisonous. This, in turn, leads to increased health risks and possible legal liabilities for the manufacturing company. To address the challenges, Factobotics, a Lithuanian robotics SME, has developed a novel solution– Multicursor. Multicursor is an intelligent non-contact polymerization quality system combining cutting-edge laser technology and machine learning models to provide a real-time response on wood surfaces curing level and quality. On the contrary to the existing solutions on the market, Multicursor is provided with a non-contact sensor, is easy to integrate into the process of manufacturing through, enabling automated quality control and data collection. Thanks to its competitive advantages the system will make measurement faster and allow zero defect manufacturing through real-time system monitoring and collection of valuable data. Multicursor is currently at TRL 6. The next step is moving on to TRL 7 that will require the introduction of the industry-grade prototype with further testing in the furniture production facilities. To ensure successful commercialization, in Phase 1 of SME Instrument, Factobotics intends to develop an elaborated feasibility study for Multicursor that is to include the finalization of Multicursor’s value proposition, the creation of the Technical Specifications for Artificial Intelligence and development of the Multicursor business plan.

Keywords: non contact sensors,curing,furniture
Design and Fabrication of Functional Surfaces with Controllable Wettability, Adhesion and Reflectivity (FabSurfWAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Finland,China,Malaysia,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 1291500.0
EU funding (EUR): 787500.0
Participants: 11
Project status: CLOSED

The project “Design and Fabrication of Functional Surfaces with Controllable Wettability, Adhesion and Reflectivity (FabSurfWAR)” focuses on the staff exchange between the partners of EU and Asia, and the development of key enabling techniques of designing and generating micro/nano surface topology with better control of bacterial growth, adhesion, friction and other tribological properties for potential applications from surgical tools, biomedical devices, to turbine blades and agricultural machines. It meets the objectives and requirements of the Marie Skłodowska-Curie Actions: Research and Innovation Staff Exchange (RISE), by establishing multiple bridges between European and Asian institutions. The ultimate goal of FabSurfWar is to set up a long-term international and inter-sector collaboration consortium through research and innovation staff exchanges between nine world-recognised institutions in the cutting-edge research area of micro/nano surface engineering with promising applications in scientific and engineering sectors. The synergistic methodologies achieved by FabsurfWAR will serve as the building blocks of the micro/nano functional surface design, fabrication, measurement, characterisation and scale up application, and thus enhance the leading position of the consortium for the scientific and technological progresses in functional surfaces and potential applications. This project is divided into six inter-related work packages: (1) Setup of knowledge base and road mapping; (2) Surface metrology and modelling; (3) Fabrication and characterisation of functional surfaces; (4) Functional surface devices and applications; (5) Dissemination and exploitation, and (6) Project management. The work packages integrate all activities that will lead to the accomplishment of all the project objectives within 48 months.

Keywords: functional surfaces,controllable wettability,surface metrology and characterisation
Development of composite Metamaterials having Negative stiffness inclusions and exceptional Damping properties (DiaMoND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-03
End date: 2020-10-25
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The EU is a world leader in the development and manufacturing of structural products for the transport industry, with the aeronautical sector alone providing more than 500,000 jobs, generating a turnover of close to €140 billion in 2013 . Noise is a serious form of environmental pollution affecting the lives of hundreds of millions of citizens worldwide and having multiple socio-economic consequences. Moreover, intense vibration can endanger the structural integrity and performance of equipment and hardware. Modern industrial structures are made of composite materials due to their well-known benefits. Despite their superior structural characteristics, composite structures exhibit poor dynamic and acoustic isolation levels compared to conventional metallic ones. In order to keep noise and vibration levels at acceptable limits, structural manufacturers are nowadays obliged to extensively employ constrained-layer damping treatments that are expensive in terms of additional mass and space usage. DiaMoND will bring together an ER being expert in ‘wave propagation and acoustics of mematerials’ and a host institution carrying leading academic know-how in ‘design, optimization and manufacturing of multifunctional composites’. The Fellowship aims at developing novel structures having exceptional damping properties combined with the outstanding structural performance of a layered composite at minimum extra mass, volume and cost. This will be attained through the inclusion of internal purely mechanical Negative Stiffness elements in the core of the structure. According to conservative preliminary simulations, a successful completion of DiaMoND will deliver structures that have a damping ratio at least 300% superior (for the same stiffness/mass fraction) to that of the structures currently employed in the transport industry. The secondment of the ER to AIRBUS will ensure the applicability of this new family of structures to real-world industrial scenarios.

Keywords: negative stiffness,damping,structural dynamics,composite structures,wave propagation
Making it happen - Scalable biphasic reactions using a nebulizer-driven continuous flow reactor (NebuFlox)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Greece
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The original ERC grant focused on proving the power that oxygen from the air had in synthesis when its light-excited state was exploited. During the ERC program, we were able to show how simple & readily accessible start materials could be transformed into high value-high interest chemicals through straightforward “one pot” operations. We were also able to show that the diversity of structures accessible using this chemistry is remarkable. Furthermore, it is highly sustainable; representing a very efficient, benign & extremely low waste approach to the production of sought-after chemical frameworks. However, one problem prevailed. While it worked exceptionally well on a small research scale, its overall usefulness and its industrial relevance were severely curtailed by scale-up issues, even when the latest continuous flow technologies were applied. The need to achieve good light penetration, combined with the poor solubility of oxygen, seemed to castrate the potential of this chemistry to provide global solutions. A key breakthrough was made towards the end of the ERC program with the realization that creating and projecting a cloud (using a nebulizer to make fine droplets) into a light filled chamber could solve ALL the problems and lead to large scale reactions. With the current proposal, we seek to explore and fully automate this highly innovative nebulizer process in order to develop a robust prototype reactor with excellent prospects for further dimension enlarging (to industrial pilot plant scales & beyond). Furthermore, it is obvious that this “nebulizer fix” may also be superbly suited to other biphasic reactions. Our plan has the support of pharmaceutical giant AstraZeneca in the form of an automation expert who will act as mentor to the program. The PI & the advisory team will pursue a number of different commercialization opportunities delineated herein and look at how best to exploit and amplify the impact of the extremely efficient prototype reactor(s).

Keywords: continuous flow reactor,synthesis of fine chemicals,singlet oxygen,sustainable synthesis,nebulizers,one pot reactions,aerosol,biphasic reactions
Melting And Geodynamic Models of Ascent (MAGMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 1994250.0
EU funding (EUR): 1994250.0
Participants: 1
Project status: SIGNED

The production and migration of magma through the lithosphere results in spectacular geological processes such as volcanic eruptions, giant ore deposits, large magmatic intrusions, and is responsible for the formation of continents on Earth. Since magmatic systems develop on timescales of millions of years and are not directly accessible, we have to reconstruct them indirectly, such as by studying exhumed magmatic intrusions, or by using geophysical methods. Interpreting these data is complicated, as geophysical techniques only give a present-day snapshot, whereas the geological record yields an incomplete picture of the underlying processes. As a result, most existing ideas on how magmatic systems work remain conceptual and are not necessarily consistent with the mechanics of the lithosphere, which hampers our understanding of such processes. Here, we will develop and employ a new generation of 3D computer models to simulate the full magmatic system in arcs in a self-consistent manner, while taking both realistic rock rheologies and evolving melt chemistry into account. We will: 1. Derive mechanically-consistent interpretations of active magmatic plumbing systems by combining geophysical and petrological data with geodynamic inverse models. 2. Obtain insights into the physics of magma migration through arcs on geological timescales, by combining numerical simulations with geological constraints from exhumed arc roots, and by targeting several well-studied magmatic intrusions. 3. Unravel how arcs are built on geological timescales, what the role and the rates of magmatic differentiation processes are in this, and how this may have formed continental crust on Earth. We can thus, for the first time, interpret the available data in a physically consistent manner. This will give deep insights in how magmatic systems develop over geological timescales and why only some evolve into large super-volcanoes.

Keywords: computational tectonics,dynamics of the lithosphere,physics of magma migration