Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A study of weaving as technical mode of existence (PENELOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-12-01
End date: 2022-05-31
Duration (months): 66.0
Total project cost (EUR): 1943771.0
EU funding (EUR): 1943771.0
Participants: 1
Project status: CLOSED

The PENELOPE project builds on the hypothesis that there was a significant but tacit contribution of textile technology involved in the advent of science in ancient Greece. Bruno Latour recently claimed that technologies require an original mode of existence that accounts for their particular form of detour. I agree and propose the technological labyrinth of threads in weaving as a paradigm for this mode. In contrast to the well-known but insufficient idea of hylemorphism (a form/idea applied to material) I suggest the concept of penemorphism (a co-existence of shifting and un-shifting threads, "pene" in Greek) that enables to describe the integration of various levels and elements that are included in each and every technology, especially the digital ones. I focus in theory and practice on the technological principles of ancient weaving. In archaic Greece, we find a veridiction, a very particular way of telling the truth in weaving terms that is hidden behind the relations of metaphor and concept or mythos and logos. I detect this veridiction in all sorts of ancient texts, be they philosophical, poetical, mythographic, cosmological, or mathematical. Ancient weaving contains framing features that are lost in modern clothing technology but were decisive for their use as a model of cosmic order. For this investigation I set up a PENELOPEan laboratory where I 1. Detect the models and topologies of weaves (ancient and modern) 2. Develop codes to make them virtually explorable, and 3. Compare different types of coding and their scope with regard to their dependence on specific systems. The laboratory work is accompanied by a comparative investigation of archaic Greek texts, a selective investigation of scientific theories that employ concepts analogous to my weaving paradigm, and an anthropological investigation of the relation of codes, notations and conditions for the development of notation systems.

Keywords: textile studies,history of digital technologies
Innovating Climate services through Integrating Scientific and local Knowledge (I-CISK)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Germany,Italy,Sweden,Sweden,Greece,Hungary,Georgia,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Developing end-user products and services for all stakeholders and citizens supporting climate adaptation and mitigation (H2020-LC-GD-2020-2, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 4998806.88
EU funding (EUR): 4998806.88
Participants: 13
Project status: SIGNED

Climate Services (CS) are crucial in empowering citizens, stakeholders and decision-makers in defining resilient pathways to adapt to climate change and extreme events. Despite advances in scientific data and knowledge (e.g. Copernicus, GEOSS), current CS fail to achieve their full value-proposition to end-users. Challenges include incorporation of social and behavioural factors, local needs, knowledge and the customs of end-users. I-CISK will develop a next generation of end-user CS, which follow a social and behaviourally informed approach to co-producing services that meet climate information needs at a relevant spatial and temporal scale. I-CISK takes a trans-disciplinary approach to developing CS by working with stakeholders in 7 Living Labs established in climate hotspots in Europe, it's neighbours, and Africa, to address climate change and extremes (droughts, floods and heatwaves) faced by agriculture, forestry, tourism, energy, health, and the humanitarian sectors. With end-users, I-CISK will co-design, co-create, co-implement, and co-evaluate pre-operational CS that provide a step-change in integrating local knowledge, perceptions and preferences with scientific knowledge. This co-production framework is unique as it (i) links climate impact and adaptation at different temporal scales from (sub)-seasonal forecasts through to climate scale projections, and (ii) explicitly considers the human-climate feedbacks of adaptation and options in a multi-timescale, multi-sector, and multi-hazard setting. The novel CS will be built on a highly customisable cloud-based web platform that I-CISK develops; freely available, and easily replicable. The I-CISK co-production framework, supported by online open courses, guidelines, business stories and strategic dissemination, will catalyse the production and adoption of CS that integrate end-user local knowledge with scientific knowledge, contribute to improved decisions and policies, and a flourishing market for end-user CS

Keywords: climate services
Spaces and Styles of Participation. Formal, non-formal and informal possibilities of young people’s participation in European cities. (PARTISPACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Switzerland,Türkiye,Sweden,Bulgaria,France,France,United Kingdom,United Kingdom
Call: Societal and political engagement of young people and their perspectives on Europe (H2020-YOUNG-SOCIETY-2014, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 2575965.0
EU funding (EUR): 1985711.0
Participants: 10
Project status: CLOSED

Existing research suggests that political participation and European orientation of young people depend on how they experience influence and involvement at local level. This reflects that individuals need the experience of self-efficacy to engage in wider communities. Research also reveals that only few young people engage in formalised participation (parties, trade unions, or youth councils) as these are not flexible enough for individualised concerns, biographies and life styles and they reflect patterns of social inequality. The project Spaces and Styles of Participation (PARTISPACE) starts from the assumption that all young people do participate while not all participation is recognised as such. The study asks for the different ways in which young people participate in decisions „which concern them and, in general, the life of their communities”. How do 15- and 30-year-olds engage with the public in formal, non-formal and informal settings and how is this supported or inhibited by local youth policies and youth work? The countries involved – Bulgaria, France, Germany, Italy, Sweden, Switzerland, Turkey and the UK – secure contrasting contexts of young people’s growing up as well as differing orientations towards Europe. The design of PARTISPACE includes: • National research literature reviews and policy analysis; • Analysis of European Social Survey data on young people’s participatory orientations; • Local case studies in one major city per country including expert interviews, focus groups discussions, city walks and biographical interviews with young people, ethnographic case studies of formal, non-formal, and informal participatory spaces. • Activating and supporting participatory action research by young people themselves. The analysis relates local constellations with national and European patterns and discourses of youth participation. Findings are constantly discussed with representatives of the youth sector at local and European level.

Keywords: young people,learning,youth policies,biographies,urban policies
IceXL: Advanced modeling and slicing software for additive manufacturing (IceXL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

The ICEXL proof of concept project targets the pre-commercialization of a novel software for additive manufacturing of complex technical parts. It relies on innovative approaches from the SHAPEFORGE project (Stg-2012-307877) and in particular our software prototype IceSL. We aim at unlocking the full potential of additive manufacturing in terms of the complexity of the parts that can be designed and manufactured and in terms of customization possibilities by non-experts in computer aided design. A key challenge of additive manufacturing is to deal with extremely complex designs having micron-scale details in possibly meter-scale objects. Such a profusion of details is both a challenge for the engineers -- manually creating such details while following precise specifications is a daunting task -- as well as a technical challenge due to the size and complexity of the considered geometries. Another challenge is to allow non-expert users to customize parts and to adapt them to a specific usage. Our software prototype IceSL has the potential to answer both challenges. Complex objects are described as combinations of base shapes (e.g. union, intersection, difference, offsets). IceSL stores this list of operations in a digital blueprint that retains design parameters such as construction rules and dimensions. The blueprint is many times smaller than a triangle mesh of the full final object. The decisive advantage of IceSL compared to other software is that it directly produces instructions for the manufacturing process from its digital blueprint. It allows the interactive visualization of the final object as well as the interactive edition of the blueprint parameters. The goal of the ICEXL project is to turn the research prototyped in IceSL into a software product, and to demonstrate its applicability on industrial case studies. Potential customers include preliminary contacts within the medical, automotive, aerospace and consumer market domains.

Keywords: additive manufacturing,solid modeling,slicing,micro structures
Efficient and Light Electrical Compressor for Tilt-Rotor Aircraft (ELECTRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Romania,Netherlands,Netherlands
Call: High efficiency full electrical low pressure Compartment Pressure Control System for tilt-rotor applications (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-02-01
End date: 2023-03-31
Duration (months): 50.0
Total project cost (EUR): 1874295.0
EU funding (EUR): 1200000.0
Participants: 3
Project status: SIGNED

The main objectives of the proposed ELECTRA project are: 1. The development of an optimal architecture for a bleedless cabin pressurization system (CPS) 2. The development, manufacturing, test and qualification of CPS hardware suitable for flight testing on the next-generation tiltrotor technology demonstrator To achieve the objectives, ELECTRA will: 1. Set up a simulation platform 2. Perform system-level and equipment-level trade-off analyses 3. Develop equipment hardware: cabin pressure management system, electrical compressor, electronic control unit and its firmware, outflow valve and several other system components 4. Develop a test rig for hardware testing, emulating the cabin pressurization system, and test the developed hardware 5. Develop a prototype qualification unit and perform environmental qualification tests 6. Develop a prototype flight unit, cleared for flight on the next-generation tiltrotor technology demonstrator ELECTRA contributes to task 1.6.3 of the Joint Technology Programme, “Pressurization and Environmental Control System Components Design, Manufacturing and Testing”, by contributing to these JTP objectives: • Reduction of carbon emissions through improved energy efficiency • Reduced cost of ownership • European industrial leadership on ‘Smart, Green and Integrated Transport’ • Improving mobility through new mobility concepts (more flexible, resilient, effective and affordable) • Spin-off from research innovation activities to other aircraft

Keywords: aircraft compressor,cabin compressor,electric compressor,cabin pressure control system,more electric aircraft
The identification of the Combinatorial Transcription Factor network exerting different roles in Hematopoietic Stem Cells. (TFs-HSCs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Deciphering the TF network regulating hematopoietic stem cells (HSCs) would be important in treating acute myeloid leukemic (AML) patients; a rapidly progressing hematopoietic malignancy with poor prognosis and survival rate. Hematopoiesis is the process of generating all the mature blood cells from HSCs. Its regulation is, even until now, not fully understood and studied in all its levels. HCSs and hematopoietic differentiation are the key elements that are regulated by the cellular environment (extracellular/intracellular signals) funnelled into transcription factors (TFs). Notably, the human genome contains ~22000 genes estimating to encode 1391 TFs. I have already identified 420 TFs expressed in HSCs. Until now 20-30 TFs have been well-characterized in hematopoiesis, and my aim is to identify the role of the uncharacterized TFs required for hematopoiesis. First I will identify which of the 420 TFs have an effect in HSCs in vitro (WP1). Then I will test in vivo, if the TFs identified in vitro will affect hematopoiesis (WP2). Finally, I will investigate the functional properties of the selected TFs and unravel their role in chromatin organization and regulation of hematopoiesis (WP3). For all this, I will use novel state of the art methods like CRISPR/Cas9 and T2C. The accomplishment of my aims will provide new insights into how TFs regulate the generation/proliferation of HSCs. The proposal builds on my experience in data analysis, transcriptional regulation, chromatin architecture and the unique resources available at BRIC. Prof Helin, a world leading expert in hematopoiesis and cancer, and his lab have extensive experience on genetic screenings and molecular biology ensuring a successful outcome. Through this project, I aim to broaden/strengthen my expertise by acquiring the necessary technical/transferable skills assisting my future career progression to an independent researcher in the fields of molecular biology, chromatin architecture and hematopoiesis.

Keywords: hematopoiesis,transcription factors,crispr,cas9 screening
Innovative tool for personalized treatment of patients with neovascular age-macular degeneration: dosage optimization for long term efficacy treatment (EyeTREAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2019-11-30
Duration (months): 15.0
Total project cost (EUR): 122159.25
EU funding (EUR): 122159.25
Participants: 1
Project status: CLOSED

With the ageing population, visual threatening illnesses are increasing. For instance, age-related macular degeneration (AMD) is expected to affect almost 25 million Europeans by 2040. The AMD treatment consists in regular injections of the anti-VEGF therapeutic drug (Lucentis, Avastin, Eylea) into the eye ball, vitreous, for the rest of the patient life. However, the dosing intervals varies widely among the patients and there is no a clear consensus or quantitative method for evaluating the injection frequency. For that, computational tools linking the drug dose regimen and the drug effect in the retina are needed. However, such pharmacokinetic-pharmacodynamic models are still missing. Combining population pharmacokinetic and optical coherence tomography (OCT) imaging technique is a new, novel and promising approach. The drug effect can be evaluated non-invasively, measuring the central macular thickness in the retina scan. The models generated will allow appropriate individualized dosing regimen to the patients in clinics that will be anticipated from individual retina scan determinations with OCT. The optimization and personalization of dosing regimen will ensure an efficient long-lasting treatment, improving patient quality of life while reducing the burden to the health care system. Moreover, the models will increase our understanding in the treatments, constitute a pioneer tool in effect assessment in ocular therapeutic field and a first step towards more advanced ophthalmic models. The candidate has strong expertise in intravitreal pharmacokinetic and this project will advance her into clinical pharmacodynamic modelling at the renowned Centre for Applied Pharmacokinetic Research, University of Manchester. The inter-disciplinary and inter-sectoral character of the project will definitely benefit her career development as a researcher.

Keywords: ocular pharmacokinetics,pharmacodynamics,clinics,optical coherence tomography,nonlinear mixed effects model,physiologically based pharmacokinetic model,central macular thickness,pharmacometrics
PanCare studies of the scale-up and implementation of the digital Survivorship Passport to improve people-centred care for childhood cancer survivors (PanCareSurPass)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Spain,Italy,Ireland,Germany,Belgium,Belgium,Lithuania,Netherlands,Netherlands,Netherlands
Call: Implementation research for scaling up and transfer of innovative solutions involving digital tools for people-centred care (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4000000.0
EU funding (EUR): 4000000.0
Participants: 19
Project status: SIGNED

Almost 500,000 former childhood cancer patients (CCS) are now living in Europe. Compared to the general population, CCS represent a vulnerable population as they are at an increased risk of developing health problems, known as late effects, resulting in excess morbidity and mortality. Many survivors are unaware of their personal risk for specific late effects, which reduces their ability to manage their own follow-up care. Similarly, their treating healthcare professionals (HCPs) lack information about care required for CCS and access to treatment data from their childhood cancer. The Survivorship Passport (SurPass) is an innovative, digital tool, developed in previous EU-funded projects, that can be used to overcome these knowledge gaps to improve people-centred long-term survivorship care. Importantly, end users (CCS, HCPs) are integral to the research, represented by three key stakeholder networks (PanCare, SIOP Europe, CCI Europe). PanCareSurPass will conduct a robust assessment of the implementation of the SurPass by first conducting a pre-implementation study in six countries (Austria, Belgium, Germany, Italy, Lithuania, Spain) representing three infrastructural scenarios in Europe. Ethical, structural, organisational, economical, national, local, privacy issues, health systems, and particular national circumstances will be taken into account throughout. An Implementation Strategy will be developed and the SurPass will be updated and validated before use in an implementation study in the six countries. The study will look at a range of outcomes including CCS activation and empowerment, CCS/HCP satisfaction with the tool, feasibility and health economics. Based on the results of the study, a Prediction Model will be developed to promote and support future implementation of the SurPass across Europe.

Keywords: cancer survivorship care,implementation science,electronic health records,interoperability
Decision Support and Information Management System for Breast Cancer (DESIREE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Germany,Greece,France,United States,United Kingdom
Call: Digital representation of health data to improve disease diagnosis and treatment (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-02-01
End date: 2019-07-31
Duration (months): 42.0
Total project cost (EUR): 3340720.0
EU funding (EUR): 3340720.0
Participants: 12
Project status: CLOSED

Breast cancer is the most common type of cancer affecting woman in the EU. Multidisciplinary Breast Units (BUs) were introduced in order to deal efficiently with breast cancer cases, setting guideline-based quality procedures and a high standard of care. However, daily practice in the BUs is hampered by the complexity of the disease, the vast amount of patient and disease data available in the digital era, the difficulty in coordination, the pressure exerted by the system and the difficulty in deciding on cases that guidelines do not reflect. DESIREE aims to alleviate this situation by providing a web-based software ecosystem for the personalized, collaborative and multidisciplinary management of primary breast cancer (PBC) by specialized BUs. Decision support will be provided on the available therapy options by incorporating experience from previous cases and outcomes into an evolving knowledge model, going beyond the limitations of the few existing guideline-based decision support systems (DSS). Patient cases will be represented by a novel digital breast cancer patient (DBCP) data model, incorporating variables relevant for decision and novel sources of information and biomarkers of diagnostic and prognostic value, providing a holistic view of the patient presented to the BU through specialized visual exploratory interfaces. The influence of new variables and biomarkers in current and previous cases will be explored by a set of data mining and visual analytics tools, leveraging large amounts of retrospective data. Iintuitive web-based tools for multi-modality image analysis and fusion will be developed, providing advanced imaging biomarkers for breast and tumor characterization. Finally, a predictive tool for breast conservative therapy will be incorporated, based on a multi-scale physiological model, allowing to predict the aesthetic outcome of the intervention and the healing process, with important clinical and psychological implications for the patients.

Keywords: breast cancer,breast unit,decision support,image quantification,image fusion,predictive modeling,breast conservative therapy,virtual lumpectomy,experience modeling,digital patient