Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developmental Language Disorder - Prevention and Intervention (DLD-PI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland,Finland,Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-10-09
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 3
Project status: TERMINATED

Developmental language disorder (DLD) is a public health concern affecting millions of children across Europe. Still, the basis for efficacious preventative interventions for it are largely unknown. To fill this gap, we must: 1) investigate mutable and least-mutable risk and protective factors for DLD, 2) develop prediction tools based on them, and 3) investigate risk and protective factors that are associated with the severity of outcomes of DLD. DLD prevention and intervention (DLD-PI) aims to tackle these questions by using high-quality, large-scale registry data available in Finland. The research will be conducted through multidisciplinary, inter-sectoral, and international collaboration with the universities of Turku and Oulu, the Finnish Institute for Health and Welfare, Helsinki University Hospital, and Newcastle University, UK. Piloting has already begun with the 1987 and 1997 Finnish Birth Cohorts. These findings will be validated in a new open-access generic cohort with an unprecedented number of variables from different registers, including an expected 150,000 children with DLD out of almost 2 million children. The results of DLD-PI will have wide impact because they enable better prediction of individual trajectories of DLD. With the ultimate aim of providing a tool to use in predicting DLD, this knowledge will enable more efficient targeting and timing of preventative interventions. The results will be essential, generalizable, and advance the field of research for other developmental and learning difficulties as well. They will also be disseminated and communicated accordingly. DLD-PI adds significantly to both research in the European Research Area and the priorities of Horizon 2020. The fellow already has extensive experience in DLD research and its methodology, and the two-way knowledge transfer will prepare her to conduct and lead future epidemiological studies in a field critically lacking specialists.

Keywords: developmental language disorder,prevention,intervention,social inequalities,longitudinal,cohorts
Laser-Based Bioprinter (Laser-Bioprint)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-10-01
End date: 2018-03-31
Duration (months): 18.0
Total project cost (EUR): 149850.0
EU funding (EUR): 149850.0
Participants: 1
Project status: CLOSED

Bioprinting is a rapidly developing technology sector aimed at additive manufacturing of tissues and organs. It is expected to lead to the most disruptive biomedical applications of additive manufacturing. Apart from tissue engineering and regenerative medicine, bioprinting applications of immediate commercial and societal benefit include the development of personalized cancer therapies and realization of in vitro tissue models based on human biology for reliable drug tests in pharma industry. The latter one is especially attractive, as it will potentially result in substantial savings of drug development costs. Furthermore, it may help to considerably reduce the need for animal studies in the foreseeable future. The need for increased resolution is one of the main technological challenges of bioprinting today. Most currently available bioprinters are based on dispensing methods. Therefore, the achievable spatial resolution is in the range of tens of micrometers. The possibility to reproduce features on the submicrometer scale would provide the missing link to accessing the complexity of natural cell environment and enable fabrication of truly biomimetic constructs.

Keywords: bioprinting,3d cell culture,tissue engineering,additive manufacturing technologies,3d printing,laser processing,microfabriction,photopolymerization
How the human thalamus guides navigation and memory: a common coding framework built on direct thalamic recordings (DirectThalamus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2025-01-31
Duration (months): 67.0
Total project cost (EUR): 1499914.0
EU funding (EUR): 1499914.0
Participants: 1
Project status: SIGNED

The thalamus is the major gateway for sensory input to the brain, and, as such, has long been thought of as a mere sensory relay station. But accumulating evidence suggests that it is crucially involved in higher cognitive functions like memory formation and navigation. However, methodological obstacles still impede full understanding of the specific role of thalamus in human cognition. The core objective of DirectThalamus is to provide an advanced oscillatory model of subcortical processing as the neuronal basis of core cognitive functions. To this end, the project will address several key questions with the aim to identify and understand neuronal processing in the thalamus involved in human cognition: How does the human thalamus code and communicate information? And how does this contribute to spatial navigation and the formation and consolidation of memories? Using my unique expertise in innovative methodologies, I will exploit the rare opportunity to record and modulate intracranial electrophysiological activity in the human anterior thalamus. Together with intracranial recordings from the human hippocampus and comparative fMRI data from healthy subjects, these data will be used to test and establish a common coding framework for memory and navigation, highlighting contextual information processing as fundamental thalamic function. By directly recording and stimulating intracranial thalamic activity, DirectThalamus will provide novel and causal insight into thalamic mechanisms underlying core cognitive functions. The project will thereby push the boundaries of the state of the art in cognitive neuroscience towards a comprehensive understanding of cognition. Expanding the prevalent corticocentric focus on cognition to subcortical contributions will inspire new lines of research in fundamental and clinical neuroscience.

Keywords: memory,oscillations,navigation,thalamus,cognition,intracranial eeg,deep brain stimulation
A Mycorrhizal Revolution: The role of diverse symbiotic fungi in modern terrestrial ecosystems (MYCOREV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2059147.0
EU funding (EUR): 1776025.75
Participants: 3
Project status: SIGNED

The colonisation of the landmasses by plants >500 Mya was a major turning point in Earth’s history, drastically altering the development of the biosphere and providing the basis for all terrestrial life ever since. The hypothesis that early plants were facilitated in their invasion of the land environment by forming symbioses with arbuscular mycorrhizal fungi (AMF) is widely supported by fossil and molecular evidence. My previous findings in physiology identified the role of AMF as a driving force in evolution by supporting growing nutrient demands of increasingly large plants, against a background of declining atmospheric CO2. Recently, it was revealed that the earliest groups of extant plants form symbioses with a different group of fungi - Mucoromycotina “fine root endophytes” (MFRE) and I have since shown that MFRE symbioses are nutritionally mutualistic. These findings support a new hypothesis: the earliest land plants had a wider range of symbiotic options than was previously thought with MFRE also playing an important role in their supply of nutrients. I have now discovered that MFRE symbioses are not limited to early divergent plants, but instead span the entire land plant phylogeny. Coupled with my most recent findings that MFRE symbionts are distinct from AMF in terms of function and responses to changing atmospheric CO2 concentrations, these discoveries call into question much of what we thought we knew about plant-fungal symbioses. Much of the fundamental biology of MFRE remains unknown, preventing us from understanding the true complexity of plant-fungal symbioses, how they might respond to environmental change and their potential exploitation. This project will address the fundamental knowledge gaps surrounding the diversity, structure and functional significance of plant-MFRE symbioses, paving the way for a revolution in mycorrhizal research in the 21st century.

Keywords: symbiosis,fungi,mycorrhiza,carbon for nutrient exchange,phosphorus,nitrogen,carbon,endophytes
BUILDING EXCELLENCE IN RESEARCH OF HUMAN-ENVIRONMENTAL SYSTEMS WITH GEOSPATIAL AND EARTH OBSERVATION TECHNOLOGIES (HES-GEO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Germany,Belgium,Poland
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 898250.0
EU funding (EUR): 898250.0
Participants: 4
Project status: SIGNED

HES-GEO project aims to enhance existing research capacity and stimulate scientific excellence in the Institute of Geography and Spatial Management (IGSM), Jagiellonian University, in studying human-environmental systems (HES) of the Anthropocene, along variety of urban-rural-marginal gradients, at various spatial and temporal scales and using tools and data available through Earth observation (EO) and geospatial technologies. HES-GEO will build on existing strengths of IGSM and opportunities provided by new regulations of science and higher education in Poland, combining them with the vast expertise in studying HES and in capacity building of three excellent partner institutions: Paris Lodron Universität Salzburg, Humboldt-Universität zu Berlin and Katholieke Unversiteit Leuven. To reach the HES-GEO main goal, three groups of activities will be carried out: [1] training young post-doctoral and early stage researchers in academic soft skills (scientific writing, project development and leadership) and in geospatial and EO technologies; [2] setting up research teams (RTs) led by young scientists of IGSM and supervised by experienced scientists from partner institutions, providing them guidance towards development and submission of competitive research proposals to European research programmes, and [3] establishing a Centre of Excellence (CoE) in IGSM, composed of the RTs and a new project / knowledge management and outreach unit. Building on trained young researchers developing new research ideas in the RTs, the CoE will gather the experiences of HES-GEO, and employ them beyond the project lifetime, ensuring sustainability and appropriate exploitation of project results. The three major activities of the project will be supported by diverse dissemination and communication measures, in order to increase HES-GEO overall visibility and establish research- and stakeholder-oriented networks, supporting sustainability of the future actions of the CoE.

Keywords: human environmental systems,global change,urban rural interactions,urban rural sustainability,geospatial information,earth observation
Iron speciation in the microenvironment surrounding phytoplankton cells and the consequences for Fe bioavailability (Phycosphere Fe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

The interaction between metals and microscopic plant-like organisms called phytoplankton is a key link to global carbon balance. More than a half of atmospheric CO2 on earth is taken up by phytoplankton, but iron (Fe) limits their growth in large regions of the oceans. Ongoing ocean acidification and global warming will influence Fe-stress in marine phytoplankton and hence the biological carbon fixation. Key existing knowledge gaps are the pathways by which phytoplankton take up Fe, and influences of chemical conditions in the microenvironment surrounding algal cells (i.e., phycosphere) on Fe speciation and bioavailability. This knowledge represents an impediment to understanding the complex effects of climate change on Fe uptake and oceanic carbon fixation. The project ‘Phycosphere Fe’ will determine chemical conditions and Fe speciation in the phycosphere of model phytoplankton species, quantify the role of phycosphere Fe speciation in Fe bioavailability, and investigate influences of climate change (i.e., warming and increased CO2) on Fe-algae interfacial processes. The project is key to the assessment of Fe bioavailability, growth and CO2 fixation of phytoplankton in current and future oceans, which make key contributions to global carbon sequestration. The project will improve our ability to model phytoplankton dynamics and predict biological carbon fixation in a changing ocean.

Keywords: trace metals,bioavailability,metal speciation,algae,phytoplankton,uptake
Convergence of positive and negative reinforcement in fentanyl addiction (F-Addict)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 2499748.0
EU funding (EUR): 2499748.0
Participants: 1
Project status: SIGNED

F-Addict strives to unravel the neural circuits driving compulsion in fentanyl addiction. We ask the question how fentanyl causes fast transition from medical or recreational controlled drug use to compulsive consumption. About a third of opioid users eventually loose control, which increases the risk of death by overdose; a number that is even higher for fentanyl and definitely exceeds the transition observed with psychostimulants. The neural correlate of this difference remains elusive. We posit that repetitive withdrawal leads to strong negative reinforcement, which in conjunction with inherent positive reinforcement favors the transition to compulsion. F-Addict will uncover the synaptic processes and neuronal population activity leading to addiction in a mouse model of oral fentanyl self-administration. Much preliminary data implicate activity in the mesolimbic dopamine system and upstream subcortical regions (paraventricular thalamus/habenula/basolateral amygdala) in positive and negative reinforcement, respectively. In addition, top down control, in particular by the orbitofrontal cortex may drive compulsive drug use. The proposed project will harness advanced circuit investigations for an innovative, original perspective: how does positive and negative reinforcement in fentanyl addiction contrast with current circuit models of addiction that are based on psychostimulants? In a translational spirit, F-Addict will also examine the effects of oral substitution with methadone and buprenorphine, recognized therapies for opioid addiction. Much preliminary data provides proof of feasibility and principle. We are confident that our approach at the frontiers of modern neurosciences carries the potential for groundbreaking results to answer a timely question. Unraveling the neural basis of fentanyl addiction will enhance the molecular understanding of circuit modulation to shape future therapies facing the still growing opioid epidemic.

Keywords: addiction,opioids,synapses,circuits
Significant or trivial: Fungi in Polar Ecosystems (F-Pole)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Fungi are major components of the Earth's biosphere, playing a pivotal role as decomposers and recyclers of nutrients across different environments. However, fungal diversity and function in marine environments has been poorly studied, leading to a biased picture of fungal distribution. Latest studies indicated a distinct marine fungal diversity, including chytrids which can affect algae and zooplankton communities because of their parasitic lifestyle or function as food source. The project intends to investigate the importance of marine fungi in polar-regions, environments that promote the occurrence of endemism and thus the detection of novel species. WP1 aims to study marine fungal diversity and distribution and to provide novel and unique information on the influence of environmental variables on the biodiversity of fungi in these important and changing environments. Two hypotheses will be tested in this work package: firstly, are the fungi identified representative of 'bona-fide' marine lineages and not land-derived origin? Secondly, do fungi represent a higher diversity in marine polar waters compared to temperate and tropical waters? WP2 aims to elucidate the genes transcribed by polar fungi in these atypical and cold environments. This work will allow me to understand the biological characteristics of these fungi that underpin their diversity and distribution profiles by using comparative meta-transcriptomic analysis of environments rich in polar chytrid lineages. Once both work packages are brought together they will help to fill the gap in our understanding of the marine environment, providing important information on ecology of marine communities. Polar environments are undergoing unprecedented changes, it is therefore crucial to understand important components of the microbial community, specifically fungi. The combination of diversity analysis and reconstruction of biological function will uniquely allow for such progress.

Keywords: illumina sequencing,meta barcode analysis,meta transcriptomic analysis,fungi,biodiversity,biogeography,arctic ocean,southern ocean
Universal system for microbial analysis of water quality to guarantee a safe and healthy agro-food sector (GREENAQUA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GREENAQUA proposal is led by the Spanish SME Centro de Investigaciones Submarinas, S.L(hereinafter CIS) whose core business is environmental consulting specialised in ecology, biotechnology, biology, natural resources and R&D in the field of water. GREENAQUA is part of CIS business strategy to enlarge their business activity lines within water market related to agro-food sector. It is known that current quality of water resources of the planet is not as high as desired and major sources of water pollution are from human settlements and industrial/agricultural activities. Thus, GREENAQUA will be, at first, oriented to agro-food sector as key market segment, in order to extend afterwards its application to other sectors. The need to take care of this resource has become a global concern and a full monitoring of water quality along the whole hydrological cycle is required. Legislation is been adapted to this new situation and a higher demand of water analysis has appeared. Despite the market needs to have real-time water monitoring devices for biological and physical analysis, there are only few commercial solutions which can analyse both parameters. In general terms, currently, such parameters are determined by archaic systems and most of them require traditional techniques for laboratory cultivation and analysis. Likewise, several R&D sensors have been developed but their results are not very successful: the majority have not been validated in real scenarios and/or have limitations related to robustness, sensitivity, accuracy and reliability. In this context, GREENAQUA proposes a new product which is a Universal Water Monitoring Device for water quality analysis, in particular, to monitor Biological Parameters in order to guarantee water quality fulfils standards regarding its use in agriculture and food production (including aquaculture).

Keywords: water,water quality,analysis devices,water pollution,competitiveness,agri food