Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Calcium-dependent Lectins in Human Pathogenic Infections: From Atomistic Understanding to Ligand Design (CaLecLig)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Lectins are proteins that bind saccharides, thus mediating cell-cell and cell-pathogen adhesion. They are therefore implicated in many devastating diseases (cancer, diabetes). The pharmaceutical industry had to leverage the remarkable progress in modern methodologies to cope with the enormous challenges of targeting lectins (flexible interactions involving calcium, multivalent ligands/multimeric receptors), producing a dozen of successful glycomimetic drugs (e.g. Tamiflu). To develop workflows comparable to traditional drug/target complexes, however, deep knowledge of lectin/ligand interactions must be gained. This project aims to fill this gap by determining the properties of Ca2+-dependent lectins, LecA/B and DC-SIGN, implicated in bacterial infections of cystic fibrosis patients and viral infections (HIV-1, Ebola), respectively. We will establish the microscopic view of Ca2+ binding to these lectins using advanced molecular dynamics (MD), verified by quantum mechanical (QM) calculations, isothermal titration calorimetry (ITC) and neutron crystallography. Then, we will work out protocol for predicting lectin-ligand binding modes and affinities using free-energy simulations, verified by NMR data. Finally, we will create a dynamic model of DC-SIGN tetramer by fitting to SAXS envelope and interpret multivalent binding types. The proposed project is novel and multidisciplinary. The applicant will acquire training in advanced experimental and computational techniques, which will re-enforce his career prospects in research and teaching. Conversely, he will transfer his knowledge of QM calculations to the host and partner institutions. This unique complementarity of competences will bring fundamental and practical understanding of lectin-ligand binding which will advance glycoscience research and industry. Future design of new patentable glycomimetics will impact Europe’s economy and society.

Keywords: carbohydrate,saccharide,lectin,calcium,multivalent,affinity,binding,pathogen,infection,immunity
European matchmaking platform for innovative transport and mobility tools and services (ENTRANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Spain,Spain,Germany,Germany,Italy,Belgium,Norway,Belgium,France,France,Netherlands
Call: 'First of a Kind' solutions for sustainable transport and mobility: EU initiative for accelerating EU-wide market access, scale up and derisking (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 17
Project status: SIGNED

ENTRANCE offers a common and legitimate European matchmaking platform and complementary off-line services designed to mobilise financial resources to accelerate the market access and scale up of “first of a kind” sustainable transport solutions, thereby reducing the European CO2 emissions and pollutants caused by the transport and mobility sector. The overall concept focus of the ENTRANCE project lies in the “supply-demand-finance” triangle that is envisaged for all transport and mobility modes and all relevant stakeholders. Through the ENTRANCE Matchmaking accelerator funnel workflow, first-of-a-kind zero, or near-to-zero, emission transport solutions will be identified, attracted and matched with potential buyers and financing opportunities and knowledge on good practices on the deployment of innovative solutions, European and national tenders, and legislation will be exchanged through the online platform. Training and brokerage activities will be executed to increase the maturity of the ENTRANCE community and bridge the gap between innovative solutions and the market. In addition, to de-risk the uptake of innovative solutions, ENTRANCE will facilitate purchase aggregation through matchmaking activities and by setting up a neutral trustee for the orchestration of purchase aggregations. Access to finance will be supported through an online funding programme database and individual and personalised innovation finance advice and support will be offered. The funding advice will combine public funding, private investment opportunities, and the best mix of alternative finance models for solution providers. Finally, ENTRANCE will facilitate cross-fertilisation and clustering activities with European transport and mobility associations and initiatives to support critical mass and achieve a coordinated European effort to boost the uptake and upscaling of innovative transport and mobility solutions.

Keywords: first of a kind zero emission transport solutions,supply demand finance triangle,matchmaking,orchestration of purchase aggregations,innovation finance support,cross fertilisation
INNOvative tools FOR dismantling of GRAPHite moderated nuclear reactors (INNO4GRAPH)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Decommissioning and environmental remediation
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Italy,Lithuania,France,France,France,United Kingdom
Call: Fostering innovation in decommissioning of nuclear facilities (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 3818634.96
EU funding (EUR): 3011061.38
Participants: 14
Project status: SIGNED

The decommissioning of closed graphite moderated nuclear reactors worldwide is still in its early stages with the majority of reactors in “safe store” condition. For these reactors, there are still considerable industrial and technical challenges that remain to be tackled even after more than 30 years of operational shutdown of the first unit. Challenges related to the dimension and complexity of the structure as well as costs for decommissioning urge for novel, more performant, safer and cost-efficient solutions for dismantling operations. INNO4GRAPH aims at developing a set of physical and digital tools and methods to be used both upstream of dismantling operations (for material characterisation and decision-making) and during dismantling operations (for handling and cutting). Tools such as 3D modelling of dismantling scenarios, measurement tools for mechanical and physical properties, mock-ups of the graphite stack and laser-cutting during dismantling operations will be developed. To ensure the cost-efficiency of dismantling scenarios and tools, INNO4GRAPH partners will collect and compare existing cost data for tools, in reference with the different scenarios, to create a benchmarking database for a future decommissioning cost estimate. The launch by EDF of a full-scale graphite power plant demonstrator in Chinon, France, in 2022 will facilitate the uptake and further development of the tools developed during the project. The participation of all European graphite reactor operators in the consortium will not only be the launch of a sector of excellence in the graphite reactor decommissioning field, but will also ensure a large uptake of results by the end-users and will contribute to achieve the highest impact both on scientific/technological, innovation and economic level.

Keywords: dismantling,graphite reactor,remote technologies,scenarios,innovative,tools and methodologies
Modeling microgels: from microscopic design to macroscopic description (MIMIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-01-31
Duration (months): 68.0
Total project cost (EUR): 1314375.0
EU funding (EUR): 1314375.0
Participants: 1
Project status: CLOSED

Soft matter provides the ideal playground for exploring physical phenomena that have no counterpart in atomic and molecular systems. A continuous progress in particle synthesis has provided a rich variety of soft, polymeric colloids, which are highly interpenetrable and can reach ultra-dense, jammed states. Such colloids offer exquisite control of material properties through a change in their internal architecture. Among this new generation of soft particles, microgels – colloidal-scale particles individually made by crosslinked polymer networks – have become a favourite model system for their responsive swelling properties and their multitude of applications. Notwithstanding their potentialities, knowledge of their behaviour from a fundamental point of view is still very limited. The present theoretical description is mostly based on simple models, which do not account for the internal, polymeric nature of the particles. Using state-of-the-art computational techniques across all scales (from atomistic to multi-blob coarse-graining), this 5-years work-program will provide an accurate model of both the microgels and of the effective interactions among them. The model will account for polymer/solvent interactions and for variation of the external control parameters at all densities, up to jamming conditions. In this way, I will develop a unified framework from the design at the molecular level of the individual particle up to the description of the macroscopic properties of the material. At all steps, I will verify my theoretical progress with experimental measurements performed by world-leading collaborators. This proposal will thus bring the current understanding of microgels to a new level: besides rationalizing existing results, it will open the way for new uses and applications of these fascinating systems.

Keywords: microgels,effective potentials,computational methods for soft matter,coarse graining,polymers,phase diagrams,viscoelastic properties
The Court of Elizabeth I – A European Drama (COEED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The enduring fascination in anglophone research with the political culture of Elizabethan England has often served to occlude the fact that responses to the Tudor monarch were formulated across renaissance Europe. A pan-European range of dramatic texts bears witness to the anxiety and consuming interest which surrounded Elizabeth I. Such texts have often been neglected or referenced briefly as points of illustration. Moreover, these texts (where afforded any consideration) have most commonly been seen in terms of national traditions of literary production, rather than integrated into a Europe-wide vision of cultural debate and exchange. None of these texts has been considered in recent centuries for their theatrical potential or placed in close conversation with Elizabethan (or post-Elizabethan) literary production. This ambitious comparative project for the early modern period will be achieved through: close & comparative reading of primary texts; evaluative analysis of existing scholarship; consultation of host’s (Institute for Research on the Renaissance, the Neo-classical Age and the Enlightenment - Montpellier 3) and European archives; consultations with supervisor and advisory colleagues across Europe; engagement in performance-related events; e-networking with academic and non-academic audiences. In the course of this European project, Hiscock will: engage in a wholly transformative training in performance-based research and e-dissemination; produce cutting-edge research which embeds multilingual studies at the heart of early modern studies; disseminate research findings to a host of academic and non-academic audiences. This project engages tightly with the Marie Skłodowska-Curie Programme by: providing professional training in key skills for the applicant, thus enabling him to access significant career progression; investing in wholly innovative interdisciplinary research; enabling international and inter-sector mobility for the applicant.

Keywords: comparative renaissance early modern drama
Innovative Enterprise Conference on Circular Economy and Access to Risk Finance (PresConfLuxDec)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: France
Call: H2020-Adhoc-2014-20 (H2020-Adhoc-2014-20, 2015)
Start date: 2015-10-19
End date: 2016-02-18
Duration (months): 4.0
Total project cost (EUR): 226810.0
EU funding (EUR): 192368.0
Participants: 1
Project status: CLOSED

The conference will address the challenges and opportunities for the finance sector when funding the circular economy and the transition from the linear to the circular economy. The conference is organized in the framework the Luxembourg Presidency of the Council of the European Union and of a partnership between the Grand-Duchy of Luxembourg and the European Investment Bank (EIB) in the framework of the InnovFin Advisory program of the European Commission. The resulting report will be presented at the conference and its findings will be discussed. The conference will allow the participants (banks, funds and all actors from the finance sector as well as public authorities, at a national and European level, responsible for the design and the implementation of state aid and support tools) to exchange best practices and know how on how to finance the circular economy while benefiting from the findings of the EIB report. The know-how developed by the finance sector will be an important support to companies implementing circular economy principals. This Luxemburg Presidency Innovative Enterprise Conference in December 2015 is of high Political priority and particularly timely as the circular economy package will be published on the 2nd of December 2015. The Conference will also allow giving to the Luxemburg Presidency a high visibility on its contribution to this major phase of President Juncker Plan. The conference will address such topics as the political response to the macroeconomic situation, ways to boost growth, jobs and competitiveness through innovation, how thefinancial instruments, facilities and accompanying measures launched under Horizon 2020 can enhance access to finance for research, innovation and SMEs and also interactions between these financial instruments, COSME's and European Structural & Investment Funds (ESIF), as well as with instruments at national and local levels.

Keywords: conference organisation,pr activities,communication activities and dissemination of results
Aggregated Quality Assurance for Systems (AQUAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Italy,Austria,Germany,Germany,Italy,Spain,Spain,Germany,Spain,France,France,France,France,France,Czechia,United Kingdom
Call: ECSEL Key Applications and Essential technologies (RIA) (H2020-ECSEL-2016-1-RIA-two-stage, 2016)
Start date: 2017-05-01
End date: 2020-06-30
Duration (months): 38.0
Total project cost (EUR): 15512787.89
EU funding (EUR): 4612947.71
Participants: 23
Project status: CLOSED

There is an ever increasing complexity of the systems we engineer in modern society, which includes facing the convergence of the embedded world and the open world. This complexity creates increasing difficulty with providing assurance for factors including safety, security and performance - particularly for safety critical systems such as the transportation, aerospace and the industrial control domains. In this project we will focus on the following: • Safety/Security/Performance to be considered together, during the overall life cycle of our products. • Flexibility across domains. • Consolidate the industrial market by reducing costs and increasing system quality and maintaining compliance with more and more exacting standards. • Improved tool features and capabilities

Keywords: cyber physical systems,co engineering,system evolution,system integration,safety,security,performance,complexity,standards,product life cycle,traceability
Movements, Migration and Emotion: East/West Mobility, Transnational Bonding, and Political Identities in Polish Activists' Biographies (MIGREMOV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2021-09-16
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

MIGREMOV (Movements, Migration and Emotion: East/West Mobility, Transnational Bonding, and Political Identities in Polish Activists' Biographies) is a qualitative research project aimed at studying the role of migration and transnational connections in building political identities and developing social movements. It focuses on the case of Polish activists from 3 movements: the lesbian, gay, bisexual, trans* and queer (LGBTQ) movement, the women’s/feminist movement and the Jewish movement. It uses the biographical method of collecting life stories, as well as a Life History Calendar to reconstruct these activists’ trajectories throughout the post-socialist period (1989 to the present). It concentrates on the interactions between the process of endorsing political identities and the experiences of East/West migration and of transnational affective ties such as friendships and erotic/amorous relationships across borders and nationalities. MIGREMOV raises crucial questions for both European societies and social sciences: How does moving physically and mentally between geo-political and cultural contexts influence the process of becoming and being an activist? Does activism create specific opportunities and paths toward transnational lives? How do national identities and political ones intersect, and transform over time, in such contexts? Special attention will be given to the role of emotions, for traveling between contexts and transnational bonding is as much of an emotional journey as activism itself. Therefore, the various emotions attached to places (Poland and abroad, East and West, city and countryside…) and periods (moments of changing places, stays abroad and returns to Poland, encounters with new friends or partners, moments of higher or lower level of activism, etc.) will help outline the emotional maps parallel of these trajectories.

Keywords: social movements,gender and sexuality,religion and ethnicity,political identity,migration,nationalism,transnational space,emotions,europe,east,west divide,poland,biographies
Mapping the inner flow around accreting black holes (BHmapping)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 134462.4
EU funding (EUR): 134462.4
Participants: 1
Project status: CLOSED

Understanding the behaviour of matter in the close environments of astrophysical black holes (BH) is one of the biggest challenges of modern astrophysics. This project aims to address the fundamental problem of determining the geometry of the inflowing matter around accreting BHs. The geometrical distribution of the accreted gas is a hotly disputed and still unsolved issue. Its relevance is tightly linked to the possibility of testing the effects of General Relativity in the vicinity of BHs. Moreover, it is strictly related to other fundamental problems, in particular regarding the nature and location of the X-ray source, the mechanism responsible for the launch of the jet and the determination of the BH spin. We propose to use a novel approach known as “X-ray reverberation”. This is based on the use of innovative cross-spectral-timing techniques to study the temporal response of the accreting gas to flux variations of the central X-ray source, thus allowing distances among the different emitting regions to be constrained. This project will use the best quality data, including those provided by the ASTROSAT satellite and the NICER payload. We aim to: map the evolving geometry of the accretion flow as a function of accretion state in Galactic BH X-ray binaries; study the coupling between the accretion flow and the jet; develop theoretical spectral-timing models to explain the data; investigate how these behaviours extend to the supermassive BHs in active galactic nuclei. The candidate is an experienced researcher (ER) in the field of observational X-ray astronomy, and has pioneered the application of the X-ray reverberation method to several accreting BH systems. By exploiting the long-term and renowned expertise in theoretical modelling of accretion processes around BHs of the High Energy Astrophysics group at the Nicolaus Copernicus Astronomical Center of the Polish Academy of Science, this research will allow the ER to emerge with new and competitive skills.

Keywords: accretion accretion discs,black hole physics,x rays