Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ORganizational Behaviour improvement for Energy Efficient adminisTrative public offices (OrbEEt)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Spain,Spain,Bulgaria,Bulgaria,Greece,United Kingdom,United Kingdom
Call: New ICT-based solutions for energy efficiency (H2020-EE-2014-2-RIA, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 1776625.0
EU funding (EUR): 1776625.0
Participants: 10
Project status: CLOSED

Tertiary sector buildings sector consume a sizeable proportion of EU total energy consumption and the majority of consumption is directly attributed to the operational phase of the building life-cycle. Occupant behaviour is a major cause of this consumption. OrbEEt proposes an ICT-based framework to induce behaviour change toward energy efficiency by transforming energy measurements into personalized feedback delivered through engaging user interfaces. To achieve this challenge, OrbEEt foresees dynamic, spatially fine-grained extensions of building-level Operational Rating methodologies and Display Energy Certificates to provide a detailed view of energy use in office spaces, business processes and organizational entities rather than entire buildings. The fusion of information from Building Information Models, Business Process Models and real-time energy use measurement via a comprehensive ICT cloud service - the Systemic Enterprise Operational Rating framework - will enable energy use tracking and will establish direct accountability of people, processes and spaces toward overall consumption. Exposing the direct influence of occupant behaviour on energy use enables the design and successful deployment of behavioural change campaigns in public organization buildings. OrbEEt proposes interventions appealing to intrinsic/extrinsic human motivators through intra-organization social competitions and organization-wide social collaboration endeavours. The OrbEEt framework and behavioural change interventions will undergo real-life pilot validation in four EU public buildings that provide the business, cultural and geographical diversity for demonstration of result effectiveness and transferability. Finally, the OrbEEt consortium will use a User Driven Innovation Approach throughout its development, deployment and validation of phases to leverage and actively support Open Innovation and the EU Cleanweb/start-up community toward further exploitation of its outcomes.

Keywords: behavioural change,energy efficiency,systemic energy savings,operational rating,display energy certificates,public buildings
Thrombolytic Nanobody Therapy for Dissolving All Types of Blood Clots (TANO-TAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 51.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Thrombosis, the formation of a blood clot inside a blood vessel, causes over 16 million deaths annually and is a growing global burden with substantial economic costs. Thrombi consist of von Willebrand Factor (vWF) with or without fibrin. Current thrombolytic therapies, like tissue plasminogen activator, target only fibrin, limiting their efficacy. These therapies are also costly and have safety concerns, making them inaccessible to many patients. We are developing TGD001, a groundbreaking thrombolytic nanobody therapy that targets and dissolves all types of thrombi, regardless of their composition. This first-in-class compound features a vWF-targeting nanobody domain that locally induces the degradation of both vWF and fibrin, limiting its activity to pathological thrombi and minimizing the risk of bleeding. TGD001 promises to revolutionize thrombolytic treatment by offering a safer, more effective, and widely accessible solution. The market opportunity for TGD001 is substantial. To demonstrate its ability to target all types of thrombi, we have chosen two lead indications with different thrombus compositions: acute ischemic stroke (AIS) with fibrin-rich thrombi, and immune thrombocytopenic purpura (iTTP) with vWF-rich thrombi. The annual peak revenue of our beachhead indications is expected to surpass €6B. Expansions to other common and severe thrombotic indications would provide an additional market opportunity of €56B. Our expert team in protein engineering, thrombosis, and drug development is advancing TGD001 through clinical trials and regulatory approval. To develop a scalable production platform and reduce high costs, we seek a €2.5M EIC grant for essential CMC activities. Subsequently, €15M in equity funding will support Phase 2b studies and cover CMC commercialization costs. EIC funding is crucial to accelerate TGD001's development and market entry, ensuring timely patient access and establishing a competitive position in global healthcare.

Keywords: thrombosis,vwf targeting,acute ischemic stroke ais,thrombotic thrombocytopenic purpura ttp,nanobody
AxS: A novel, adjustable, noninvasive insulin-coupled nanoplatform transport system for brain delivery of therapeutics (Nanocarry)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Therapeutic monoclonal antibodies (MAbs) have revolutionised disease treatment, but only negligible amounts of an injected antibody reach the brain due to the blood brain barrier (BBB). A dramatic case is brain metastasis in breast cancer (BCBM): transformative first line MAbs are not effective when the tumour metastasizes to the brain. 5-year survival is 0%. Nanocarry has developed AxS, an insulin-mediated adaptable nanoparticle platform for transporting MAbs and other small molecules across the BBB to make the brain accessible to these therapies. AxS particles increase brain delivery by 10x-30x over unchaperoned cargo, with efficiency at least twice that of any comparable receptor-mediated transport system that has been devised to date. Each AxS particle can be loaded with up to 30 MAbs, plus a small molecule chemotherapy. The combination on a single particle is highly effective and shows powerful anti-tumour effects in vitro & in vivo, in mouse breast cancer + brain metastasis (BCBM) models. AxS with multiple copies of two anti-cancer MAbs strongly inhibited tumour growth in the brain, and completely eradicated tumours outside the brain. Uniquely, AxS’ specific constellation of linkers tailored to each of the 3 cargoes (2 MAbs + chemotherapy) allows retention of function, and multiplication of tumour-binding and killing capacity, but protection from uncontrolled life-threatening toxicity by masking of the chemotherapy drug until reaching its target in the brain. The AxS nano-gold core is proven safe and allows real time computer tomographic (CT) imaging, to confirm delivery and targeting. With four patents covering our innovation and EIC’s support, we aim to outlicense AxS008 to a pharmaceutical company by following up promising preclinical studies on mouse models of BCBM, completing safety/toxicity studies, manufacturing, and Phase I/II clinical trials, and accelerate market approval through Orphan and priority medicine (PRIME) status in the EU.

Keywords: nanoparticle delivery platform,blood brain barrier,breast cancer with brain metastasis,brain tumour,insulin transcytosis,nanochemistry,multi drug platform
Ultra Precise Selective Laser Eching Using Special Optics (UPS LET US OPT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Lithuania
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 3200000.0
EU funding (EUR): 3200000.0
Participants: 1
Project status: SIGNED

The future of advanced packaging in semiconductors is here, and it's reshaping our world. We're moving beyond the constraints of traditional silicon and organic substrates, embracing the transformative potential of glass core technology. Glass, with its unmatched electrical insulation, mechanical stability, and pristine surface, is the ideal platform for the high-density interconnects essential for tomorrow's cutting-edge devices. It’s a revolution driven by the insatiable demand for smaller, more energy-efficient, and more powerful devices. The process of forming holes in glass and the singulation of glass core substrates remains a significant challenge and is currently under intensive research and development. Traditional methods like laser drilling and etching are being refined to achieve the precision and reliability required for high-density interconnects. Additionally, the singulation of glass substrates, which involves separating individual units from a larger sheet, poses difficulties due to the brittleness of glass. Researchers are exploring innovative techniques to overcome these obstacles and ensure the scalability and cost-effectiveness of glass core technology. WOP has successfully addressed essential technological bottlenecks of glass processing by achieving Technology Readiness Level 6 (TRL6), completing experimental manufacturing line. UPS LET US OPT will transform glass core micro-machining technology that is beyond existing method. This transition is highly challenging and requires substantial expertise. We have established a clear development roadmap. The first step involves utilizing the EIC Accelerator's €3,2 million support to address bottlenecks in the industrial pilot line. The second step, following the acquisition of an additional total €30 million in investments, is to establish the scalable pilot line. The third step, projected for 2032-2035, involves securing up to €300 million in investments to construct 5 to 7 factories.

Keywords: glass micro processing,photonics,semiconductor,advanced packaging,chips
CONCRETE WITH ZERO WATER IMPACT - READY-MIX, PREFABRICATED AND FOR DESIGN (Milk Ceramic Srl)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The Startup recovers waste milk from the dairy industry to use it in the industrial production of concrete with zero water impact. Waste milk from the dairy industry is used to eliminate the use of pure water in the concrete industry, eliminating negative environmental impacts with the Mission of preserving groundwater resources and surface water basins across the planet. Through Know-How, the Startup has developed a new zero water impact concrete mix made of milk from which it has developed 3 innovative products: Milk Brick for the precast concrete industry, Milk Concrete for the Ready-mix concrete industry and Milk Ceramic for the designer coverings industry. The Startup has developed a Business model based on the criteria of the Circular Economy, the founders have successfully completed the TRL7 in 5 years of work on Deep Tech. Innovative zero water impact concrete solutions are applicable in any concrete production plant in the world. The purpose of the EIC's Subsidy and Investment request concerns the acceleration of the Technology Transfer of technology in Italy, Europe and around the world in order to generate a strong positive impact in the construction sector by eliminating the consumption of pure wMilk Concrete is a Startup that has developed a zero water impact concrete obtained from the valorisation of waste milk from the dairy industry through a Business model based on the new circular economy criteria.

Keywords: the startup has developed and validated in trl7 a new innovative concrete composite with zero water impact the purpose of the grant and investment proposal is to accelerate the technological transfer
Next-Gen Wireless Chip and Antenna Tech for Wi-Fi 8 (SWIFT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 3557737.5
EU funding (EUR): 2490416.25
Participants: 1
Project status: TERMINATED

Pharrowtech's innovative project aims to revolutionize wireless communication by integrating millimeter-wave (mmWave) technology into the future Wi-Fi 8 ecosystem. Leveraging expertise developed over 15 years at imec, a global leader in nanoelectronics, semiconductors and digital technology, Pharrowtech focuses on advancing chip and antenna technologies that promise to propel Europe to the forefront of wireless communication. This project envisions Wi-Fi 8 as a transformative force, offering speeds up to 100 times faster than the state-of-the-art and ensuring reliable, high-performance connections. By tapping into the mmWave spectrum, offering 10x higher frequencies and 10x wider bandwidth, Pharrowtech addresses the spectrum shortage, making connections more robust as data demands continue to increase in our digital world. The proposed project prepares the ground for the integration of our mmWave technology into Wi-Fi 8. The work encompasses optimization of wireless system design, refinement of critical components through RFIC and analog block design, enhancement of adaptability through digital processing and software development, and real-world validation to overcome challenges like signal penetration and range limitations. This undertaking positions Pharrowtech as a key player in addressing the evolving needs of various industries, including smart cities, Industry 4.0, healthcare, AR/VR and beyond. The successful execution of this project not only signifies technological leadership but also opens new markets, enhances Pharrowtech's competitive edge, drives revenue growth, and fosters strategic partnerships, reinforcing the company's commitment to reshaping the wireless communication landscape. It will also help strengthen the EU’s technological sovereignty in this key sector.

Keywords: millimeter wave mmwave,wi fi 8,wireless communication,high frequency technology,high speed wireless communications,antenna design,telecommunications,semiconductor design,wi fi
NUWA PEN: THE SMART PEN THAT DIGITIZES YOUR HANDWRITING ON ANY PAPER (Nuwa Pen)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Introducing the Nuwa Pen by Nuwa Spatial BV—a groundbreaking blend of traditional writing and digital technology. This smart pen is equipped with multiple cameras, sensors, and a microcontroller, capturing every stroke in real-time and syncing your notes to any device. With the Nuwa Pen app, you can access and organize your notes anywhere. For enhanced functionality, Nuwa Pen+ offers a subscription service to convert handwriting to typed text and sync notes with Google Mail, iOS Calendar, ToDoist, and more. The Nuwa Pen prioritizes security with multi-layer encryption for handwritten notes. It captures, processes, and encrypts notes in real-time via its microcontroller. Bluetooth transmission is encrypted for syncing with the Nuwa app. Finally, notes are encrypted for cloud storage. Designed for those who cherish pen and paper, the Nuwa Pen ensures the security of your notes with multi- layered encryption. Future updates will introduce new features to cater to evolving user needs. Perfect for professionals, artists, designers, and students, the Nuwa Pen brings your handwritten notes and doodles to life, merging simplicity with innovation.

Keywords: writing tools,productivity tools,note digitization,app synchronization,data protection and privacy
Circular Economy made easy and more profitable for communities (Reviver)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1913625.0
EU funding (EUR): 1913625.0
Participants: 1
Project status: SIGNED

Cycled was founded to tackle the problem of ineffective recycling and connect recyclers to sources of clean, sorted and traceable waste to unlock environmental and financial benefit. Annually, €438bn worth of materials are burnt or buried, resulting in 1.6bn tonnes of carbon emissions (5% of all global emissions). Approximately, 75% of waste is recyclable and has a significant financial value. A circular waste management approach has the potential of reducing costs and pollution levels by 72-81% and 76% respectively. To enable this, waste quality is important, relying upon the provision of clean and sorted recyclables. The biggest challenge in delivering quality recyclables from waste is contamination, which can render a whole batch of material unviable, or significantly reduce its value. As much as 30% of what enters the recycling chain is contaminated. Central sorting is complex, expensive and can have the opposite effect on contamination reduction, whereas source sorting depends on the unreliable practice of users putting items in the right collection point. With support from the Eureka Eurostars programme, Cycled have developed Reviver, the world’s most advanced, source-sorting and front-end collection system. It uses novel, AI powered ‘deep tech’ machine vision technology, and our patented sorting technology to automatically identify and segregate mixed waste of any type into the correct collection bin directly within the community. It also recognises brand, enabling complete closed-loop traceability. Reviver is enhanced by a unique incentive mechanism that can offer community members financial rewards (up to €0.7) per clean item of recyclable waste through our Cycled Rewards App. We deliver, clean, sorted recyclables from public locations, encouraging good user behaviour and compensating for mistakes. EIC support will allow us to refine, scale and launch Reviver, meeting the demand for multi-stream source-sorting and seize a global opportunity of €430bn.

Keywords: recycling,waste,sorting,segregation,plastic,contamination,circular economy,climate change,ai enabled image recognition
Socio-environmental trade-offs and synergies in terrestrial carbon-water coupling in a changing Planet (TYPIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Terrestrial carbon and water cycles are strongly coupled. Rising atmospheric CO2 and climate change have accelerated terrestrial water cycle, causing reduced soil moisture, and more frequent and severe droughts. Such environmental changes have modified vegetation functions, endangering the stability of terrestrial carbon budget. Human activities, such as deforestation and intensive water use, have further influenced carbon-water coupling by exacerbating external perturbations. A weakening of the terrestrial carbon sink induced by progressive water stress conditions could further destabilize the climate system with potential dramatic consequences for human societies. Despite its importance, the sensitivities of terrestrial carbon-water dynamics to socio-environmental changes remain elusive. The complexity of the topic, its interdisciplinarity, together with knowledge and methodological gaps in observing, understanding, and predicting carbon-water coupling, have hampered so far substantial progresses. TYPIC aims to respond to such emerging global challenge by addressing two key questions: How does terrestrial carbon-water coupling respond to socio-environmental changes? How have socio-environmental trade-offs and synergies influenced the trajectories of terrestrial carbon-water dynamics over the last decades? Here, I propose to investigate the subject with a novel approach that builds on the integration of Earth observations with big-data technologies. Satellite retrievals will be used in combination with advanced statistical tools to quantify spatial and temporal variations in terrestrial carbon-water coupling at the global scale. The underlying socio-environmental mechanisms will be disentangled through causal inference methods. Hotspot areas subject to amplification or compensatory effects between environmental and human factors will be finally identified to assist the development of land-based mitigation actions and the long-term sustainability of water resources.

Keywords: terrestrial carbon and water cycles land atmosphere interactions ecosystem water use efficiency human activity biophysical and biogeochemical processes climate change