Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OPEN and co-created ViRtual worldS for Europe (OPENVERSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Belgium,Italy,Switzerland,Ireland,Germany
Call: Supporting the emergence of an open human-centric Metaverse (CSA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 12
Project status: SIGNED

Europe calls for the emergence of virtual worlds that characterises themselves for being open, transparent, inclusive, ethically and environmentally responsible, but also capable of restoring the technological sovereignty of EU industry in the global scenario of competition. Such European virtual worlds would foster the following benefits: a) Higher accessibility, greater freedom and control, lower barriers to entry and more equitable distribution of resources; b) Interoperability, privacy and security as well as data ownership: open human-centric virtual worlds would be able to interoperate with each other; c) More innovation, creativity, and social benefits: open human-centric virtual worlds would foster a collaborative environment where developers and users could work together to create new experiences and features. In that regards, the overarching aim of OPENVERSE is to contribute to laying the foundations of such European virtual worlds by establishing a knowledge base on it, setting up and animating a community of stakeholders, testing a methodology that combines user co-creation and XR in real world cases of industrial and societal relevance, exploring relevant ethical, legal, IPR and single market challenges, and producing industry standards as well as a technology and policy roadmap and recommendations to guide the future establishment of the Open virtual worlds concept in Europe and worldwide.

Keywords: human centric metaverse,open metaverse,co created metaverse,technology foresight,research and policy roadmap,standardization,technology watch,market place,ethics,ipr and governance model
Optimization and commercialization of a Behavioral Mobility Digital Twin to accelerate Smart City transition (DYNAMO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 3600000.0
EU funding (EUR): 3600000.0
Participants: 1
Project status: SIGNED

By 2050, the urban population is projected to reach 6.7 billion, exacerbating existing issues like traffic congestion, energy consumption, and greenhouse gas (GHG) emissions. With urban centers already contributing over 60% of global emissions, there is an urgent need for smart city technologies to achieve carbon neutrality. European cities alone lose €110 billion annually due to traffic congestion, highlighting the economic stakes. The transformation of urban mobility through vehicle electrification, soft mobility, and multimodal alternatives is critical. However, real-time data access, robust integration of technological and social factors, and overcoming bureaucratic hurdles remain significant challenges. Insight Signals' Digital Twin Platform, DYNAMO, addresses these pain points by enabling cities to conduct human-centric simulations with unprecedented accuracy. Unlike traditional solutions, DYNAMO integrates diverse data strands and insights from social and cognitive sciences to offer a comprehensive, real-time model of urban dynamics. This allows for effective resource distribution, predictive analytics, and proactive policy-making. The platform supports multi-sectoral integration, enhancing mobility management, infrastructure optimization, and economic efficiency while promoting community well-being and safety. In the intended EIC project, the company will expand DYNAMO’s use cases, simulate demographic changes, and model decision-making with continuous real-world data updates. It will evaluate environmental and health impacts, enhance user interfaces, and develop scenario testing tools. Lastly, Business development efforts will focus on marketing, expanding the sales force, and entering new markets, starting locally near Paris and scaling to European and international clients.

Keywords: smart city,urban mobility,smart mobility
IDP-121: PIONEERING TARGETED THERAPY FOR THE UNDERLYING DISEASE DRIVER IN MULTIPLE MYELOMA (HaemoMyc)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Multiple Myeloma (MM) represents the second most common haematological cancer, with 176k new cases and 117K deaths per year. Despite advancements in treatments, it remains incurable. The disease is strictly associated with cMyc deregulation, a hallmark to transition from a non-pathological monoclonal gammopathy (MGUS) into a pathological disease (Multiple Myeloma). No current therapy in MM targets cMyc, the underlaying disease driver, which may explain the recalcitrant relapse and refractory component of the disease that forces patients to continuous treatments, going through multiple lines of treatment until no therapeutic option is left. Our novel approach addresses this unmet need, presenting a transformative opportunity in the MM market by offering a new leading treatment. IDP-121 is the first product of INTRAMETRICS platform, a unique technology that allows targeting intrinsically disordered proteins (IDPs), disease drivers considered undruggable, such as cMyc, directly binding to the IDPs and promoting its degradation. IDP-121's ability to treat and potentially prevent MM opens new possibilities for patients. IDP-121 has entered Phase I clinical trials in haematological cancers. Support from the EIC Accelerator project for the Phase II trial of IDP-121, will evaluate clinical benefits and de-risk our technology, facilitating a partnership with a major pharmaceutical company to bring IDP-121 to market for heavily treated patients.

Keywords: haematological cancers,clinical trial,cmyc,multiple myeloma
Vertex operator algebras from supersymmetric quantum field theories - dualities, new structures and relations (QFT2VOA-DuStRel)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

A main goal in theoretical physics is to understand foundational aspects of quantum field theories, such as their algebraic or categorical structures, and much of the recent progress in this direction has been deeply linked to advances in mathematics, notably vertex operators algebras (VOA). This interplay has generated surprising insights in both directions, particularly through relations between three-dimensional supersymmetric quantum field theories and certain distinguished VOAs. The latter capture special algebras of local operators, which can be defined from the boundary sector of the parent three-dimensional theories though a twisting procedure, and they are expected to provide meaningful classification invariants for these by encoding fundamental algebraic data. Nevertheless, the twist VOAs related to general three-dimensional supersymmetric gauge theories remain largely mysterious, with physical analyses usually limited to simple examples. To overcome this impasse, an innovative approach developed by the applicant constructs twist VOAs for large classes of theories as chiralizations of corresponding moduli spaces of vacua. This is a rigorous, systematic procedure which lifts the classical functions on these associated geometries to generating currents of the VOAs, and provides powerful insights into hidden VOA structures. Supported by preliminary data, this breakthrough enables: 1) a systematic analysis of physical symmetries and relations - such as 3d mirror symmetry - from a VOA perspective, as well as 2) concrete realizations of new and intriguing logarithmic VOAs through the lens of supersymmetric quantum field theories - which will be the main objectives of this action. The proposed research projects tackle fundamental and technically challenging long-standing questions in quantum field theory by creatively using the newly developed technology of chiralization, and they are expected to make an impact by establishing new exact methods of analysis.

Keywords: vertex operator algebras,w algebras,supersymmetric quantum field theories,quiver gauge theories,nakajima quiver varieties
Credible, Legitimate Evidence and Accurate Responses (CLEAR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2230000.0
EU funding (EUR): 2230000.0
Participants: 1
Project status: SIGNED

Over 5 million academic articles get published annually, most it fails to reach a broad relevant audience. Exploring, reading, and interpreting scientific results is a time-demanding task, as researchers spend nearly a quarter of their time reading studies, most of which turn out to be irrelevant. This affects the academic sector, but also corporate R&D departments, deep-tech companies, journalists, government and policy-making bodies, as we miss out on opportunities for innovation. Current solutions such as paper repositories, search engines, and AI platforms provide vast amounts of data and support, but lack the ability to personalize, contextualize, and synthesize information to make research accessible, understandable, and actionable. We have built Proem, a revolutionary AI platform that enables anyone to read and understand scientific research. We apply custom Large Language Models and cutting-edge Retrieval-Augmented Generation to translate complex academic papers into easy-to-read personalized summaries, and help the user interrogate the full publication. Our diverse and growing team is passionately driving Proemial’s mission to revolutionize how academic and scientific knowledge is communicated and utilized across the globe. We are currently developing a premium feature set tailored specifically to research-intensive organizations. These features will help teams discover, share, and discuss the latest research in a secure, private environment, reducing the time needed to apply new knowledge and technology to their products and services. Although being on the edge of a unique opportunity to disrupt the research dissemination market, we currently experience a funding gap of €5.79M. EIC’s financial support will enable us to finalize the premium features features, test and validate our system, and reach the broader market. It will also de-risk the project for additional investors and strategic partners, enabling further growth.

Keywords: knowledge management,scientific publishing,software,research,ai,randd,accessible research,research methodology,research dissemination,ethical ai
Complex Light INside Channelled Hollow-core for FCS nanoparticle characterization (CLINCH-FCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Fluorescence correlation spectroscopy (FCS) is an innovative technique for the detection and characterization of nanoscale species within their natural environment. It has successfully measured protein-protein and protein-lipid interaction dynamics, determined spectroscopic parameters of fluorophores and monitored binding constants among diffusing species. However, current FCS systems, predominantly based on confocal microscopes, have large footprint and inflexible focal observation volumes, limiting their applicability outside controlled laboratory settings. There is a strong need for compact, flexible FCS solutions. My approach addresses this need by exploiting the interaction between diffusing nanoparticles (NPs) and complex light fields within a hollow-core optical waveguide (HCW), nanoprinted directly onto an optical fiber facet. This advancement not only paves the way for a portable FCS tool suitable for clinical environments but also has the potential to enhance existing FCS technology. Our device offers two major advantages: (i) prolonged observation times due to the confinement of NP diffusion within the waveguide core, and (ii) rapid detection that surpasses image-based techniques by recording only emitted powers. By integrating extended observation periods with high acquisition rates, my FCS system facilitates the study of fast dynamic processes and interactions at the single NP level, addressing fundamental questions in life sciences, material science and light-matter interactions in general. Furthermore, my opto-fluidic platform supports both fluorescence and scattered light detection, enabling the investigation of NPs that cannot be fluorescently labeled. Notably, it allows for simultaneous measurement of fluorescence and scattered light, unlocking new pathways for exploring NP processes, such as fluorescence quenching.

Keywords: fluorescence correlation spectroscopy hollow core optical waveguide characterization of nanoscale species diffusing nanoparticles optical fibers opto fluidic technology 3d nanoprinting
The implementation of predictive coding across the auditory hierarchy (PredInCon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Posing the brain as a predictive system has become a guiding principle that has proven to be particularly fruitful in the study of perceptual processes. Perception is understood as an inferential process in which the brain combines its noisy sensory input with predictions generated by internal models. In this way, the contents of conscious experience would be determined by the hypothesis about the state of the world, with the highest posterior probability. One popular algorithmic incarnation of the predictive processing ideas is predictive coding, in which the brain implements a hierarchy of generative models, where feedback connections carry predictions and feedforward connections carry prediction errors. The brain would minimize these prediction error by updating its internal models. While compelling, this proposal leaves open several issues. It is not yet clear how a predictive perceptual system could be both sensitive to expected and to surprising stimuli. Bayesian integration of sensory evidence and prior probability of the hypotheses (predictions) might offer an optimal solution. But some authors have argued that Bayesian integration would result in a bias toward the expected. Therefore, the question of how conscious experience emanates from the interaction between predictions and prediction errors remains open. Predictive coding assumes separate neuronal populations representing predictions and prediction errors, which would reside in different cortical layers. This proposal remains largely untested in humans, in particular in the auditory domain. This project focuses on the auditory domain, where the ability to predict the incoming sensory stream is fundamental for making sense of everyday auditory scenes, especially in the presence of noise. I will tackle the aforementioned open questions by implementing challenging auditory signal detection tasks, and by combining fMRI data at ultra-high field (7 Tesla), and cutting-edge computational modelling.

Keywords: predictive coding,fmri ultra high field,dynamic causal modelling,auditory processing
AWAKENING SLEEPING BEAUTIES: UNLOCKING NEW EUROPEAN BAUHAUS AND NATURE-BASED SOLUTIONS VALUES FOR A MORE SUSTAINABLE, INCLUSIVE AND RESILIENT SOCIETY (Sleeping Beauty)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Austria,Latvia,Poland,Italy,Sweden,Greece,Spain,Belgium,France
Call: Demonstrating the potential of Nature-based Solutions and the New European Bauhaus to contribute to sustainable, inclusive and resilient living spaces and communities (HORIZON-CL6-2024-BIODIV-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 5323038.75
EU funding (EUR): 4997720.63
Participants: 21
Project status: SIGNED

The SLEEPING BEAUTY project aims to rejuvenate neglected urban, peri-urban, and rural spaces across Europe through the integration of Nature-based Solutions (NBS) and the core values of the New European Bauhaus (NEB). By addressing diverse climatic contexts, this initiative promotes sustainable, inclusive, and resilient communities. The project leverages NBS to enhance biodiversity, foster natural beauty, and provide multifunctional public spaces, aligning with NEB’s principles of sustainability, beauty, and inclusiveness. SLEEPING BEAUTY seeks to transform underutilized and overlooked spaces into vibrant, biodiverse areas that reconnect people with nature. This holistic, co-creative approach combines innovative design and artistic interventions, encouraging collaboration among citizens, experts, and local stakeholders. These efforts will help reshape public spaces, strengthen community ties, and foster a shared sense for caretaking of environment. By emphasizing the creative re-use and revitalization of spaces, the project will demonstrate how integrating NEB and NBS can lead to improved well-being, enhanced biodiversity, and more resilient and beautiful communities. The project’s six pilot sites will serve as showcases for replicating and scaling NBS-NEB solutions across Europe, contributing to a systemic shift in how we design, interact with, and maintain public spaces in close connection with nature and cultural heritage. The initiative promotes long-term societal transformation, focusing on strengthening human-nature relationships, cultural identity, and collective action to address pressing societal challenges like climate change. SLEEPING BEAUTY’s unique blend of artistic co-creation, sustainable spatial planning and innovation will push beyond traditional NBS approaches, setting a new gold standard for innovative, inclusive, and aesthetically compelling public spaces enabled by NEB-NBS and a new Natur-Baukultur.

Keywords: cultural heritage natural heritage co creation co governance
Flexibility to multisensory contestual information in people with sensory disabilities. (FLEX-U)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Australia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-16
End date: 2026-02-15
Duration (months): 36.0
Total project cost (EUR): 263392.32
EU funding (EUR): 263392.32
Participants: 2
Project status: SIGNED

One of the brain's main challenges is decoding and integrating information from different sensory modalities to create a coherent perceptual representation. In this perspective, the study of people with sensory disabilities can be considered a model to investigate the mechanisms behind the ability to modify and adapt behavior to external stimuli. When a system is flexible, it can modify itself to gain greater benefit based on environmental conditions. However, when the system does not develop in a typical manner, as in sensory disabilities, it may be less flexible, causing problems beyond perceptual processing and affect aspects of everyday life. Starting with this assumption, FLEX-U unites a novel combination between psychophysics and statistical/modeling analysis to investigate the flexibility/rigidity of the sensory processing mechanisms in people with and without sensory disabilities. The project's main aim will be divided into three specific objectives (SOs). SO1: Understanding of sensory flexibility in the typical individuals; SO2: Modelling of sensory inputs to predict flexible behavior; SO3: Understanding the influence of contextual information on the flexibility of sensory systems in people with sensory impairment and develop rehabilitative training. These objectives will be achieved thanks to the transfer of knowledge between the partner (UNSYD) and the host (IIT) institutions involving advanced expertise in experimental psychology, behavioral modelling, rehabilitative training, as well as solid scientific and clinical collaboration networks. The outcomes of FLUX-U will advance, not only, our knowledge about human perception and multisensory processing at the scientific level, but will help to develop a new rehabilitative training based on multisensory inputs that on a wider scale could improve confidence and quality of life in people with sensory impairments.

Keywords: multisensory perception,behavioral modelling,blindness,deafness,rehabilitation