Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gender gap in students’ achievement: the role of social, economic, geographical and cultural variables (GE.GAP-EDU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-08-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The study of academic achievement as function of ‘gender’ has received an increasing interest. Nevertheless, this topic seems still topical, at least for the following reasons: until now, some explanatory variables have been picked out but, probably, further unexplored factors exist; 2) the relationship between those factors has not been disclosed yet, i.e. it is not clear if interaction effects between them exist. In particular, the sectorial literature has investigated gender-related stereotypes’ effects on academic achievement but it has not studied possible interactions between stereotypes and the other variables frequently used to study students’ performance; 3) the inter-national comparison is undoubtedly an adequate method to deepen the study of gender-based gap. Nevertheless, the big international research institutes use national data, and it is clear that, when we use big data (such as national ones), almost automatically, some dangerous compensations occur, leading data to a false medium value. Our approach based also on the intra-national comparison is able to avoid those compensations. In fact, the comparisons between macro-geographical clusters produce better data, i.e. data that reproduce the reality more realistically, with three main consequences: 1) to improve the probability of picking out factors that can explain academic achievement depend on gender variable; 2) to guide local (inter-/national) policies; 3) to produce new data that can be used in future researches. Moreover, also the cross-national comparison (between macro-geographical areas within different Countries) could produce new important data because, through it, some possible “regularities” across different Countries can be disclosed, such as, for example, the same interaction effect between stereotypes and social-economic variables, etc. It could be an interesting headway in the field because it could indicate results that are true independently from specific context.

Keywords: gender based gap,math identity,stereotype threat,self concept
Exploring terra incognita: terrestrialization of arthropods in the era of genomics (TERRESTREVOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-15
End date: 2020-05-19
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 2
Project status: CLOSED

Terrestrialization – the colonization of the land habitat by plants and animals – is amongst the most important events in the history of life on Earth. Understanding terrestrialization is, therefore, key to understanding biological adaptation. From all animals, arthropods constitute the most successful phylum, manifest in extreme species richness and successful radiation into nearly every ecological niche. Arthropods colonized the land multiple times independently and at different times in Earth history, with terrestrial arthropods massively outnumbering the aquatic ones. This begs the questions how, when, why and how often did arthropods become successful in the terrestrial environment, constituting ideal model systems to study terrestrial adaptations at the genomic, physiological and morphological levels. In order for animals living in aquatic environments to colonize land, a number of physiological barriers need to be overcome, including massive changes to methods of respiration, water management and osmoregulation, reproduction or digestion, among others. Water balance is one of the main challenges facing primarily terrestrial animals. Osmoregulation is also highly relevant to the question about the route taken onto land, specifically whether the ancestors of a given terrestrial arthropod group came directly from a marine environment or via fresh water. The main goal of this project is to shed light on the mode and tempo of these changes through the integration of phylogenomics, paleontology and comparative genomics and transcriptomics. For this, I propose to investigate i) the genetic basis of cuticular composition in marine and terrestrial arthropod lineages, ii) characterization of genes involved in osmoregulation, and iii) lineage-specific orphan gene families that could have contributed to arthropod evolvability in terrestrialization events. The results of this project will allow an unprecedented understanding of deep-time questions in arthropod evolution.

Keywords: arthropoda,terrestrialization,genomics,transcriptomics,comparative biology
Progress new assets (one pre-new molecular entity and one first-time-in-human start) for tuberculosis that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors (RespiriTB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Belgium,Belgium,France,France,Netherlands,Netherlands,Denmark
Call: Progress new assets (one pre-new molecular entity (preNME) and one first-time-in-human (FTIH) start) for TB that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors (H2020-JTI-IMI2-2018-16-single-stage, 2018)
Start date: 2019-05-01
End date: 2025-04-30
Duration (months): 72.0
Total project cost (EUR): 9962900.0
EU funding (EUR): 6840000.0
Participants: 9
Project status: SIGNED

Despite recent progress in biomedical research, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is still the world’s leading infectious disease killer worldwide. In addition, multi-drug TB is the largest single contributor to anti-microbial resistance and poses a serious threat to global health. Treatment options are limited, and expensive, recommended medicines are not always available in many countries, and patients experience many adverse effects from the drugs. Moreover, due to the long treatment duration, compliance is low leading to more AMR in TB. Thus, there is an acute need for the development of a novel combination regimen with an indication for effective, shorter, and safer treatment of all forms of TB. The overall objective of RESPIRI-TB is to find new drug candidates as potential components of a new, more efficient combination drug regimen against TB that is less prone to resistance and allows shortening of treatment duration for TB, and multidrug-resistant TB. Such a drug combination will synergistically target the energy metabolism of Mtb or complementary targets. To achieve this, we will advance recently discovered inhibitors of the Mtb respiratory pathway. In addition, we will target the Mtb specific molecular mechanism that reduces reactive oxygen species in the cell. Finally, we will also target host-factors that are essential for the intracellular survival of Mtb. Together, we present a comprehensive plan to find novel strategies to combat TB, shorten treatment time and reduce chances of drug resistance.

Keywords: high throughput screening,structural biology,host directed target,mycothione reductase
Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils. (REDOXIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Sweden,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 144000.0
EU funding (EUR): 144000.0
Participants: 4
Project status: CLOSED

We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population. Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system.

Keywords: reactive oxygen species,nox2,thiol oxidation,chronic disease,arthritis,mechanism
Atmospheric content of the most abundant of 12CH4 isotopologues from ground-based and satellite infrared solar observations and development of a methane isotopic GEOS-Chem module. (ISOMET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 165211.2
EU funding (EUR): 165211.2
Participants: 2
Project status: CLOSED

Atmospheric methane (CH4), the second most important anthropogenic greenhouse gas after carbon dioxide, contributed to one-fifth of the increase in radiative forcing by human-linked greenhouse gases since 1750. The recent increase of its abundance since 2005 is not fully understood and the changes in the source(s) or sink(s) responsible for it have yet to be identified and quantified. The main isotopologues of 12CH4, i.e. 13CH4 and CH3D or heavy methane, are emitted with different isotopic ratios specific to emission sources and are depleted at different rates. Thus, they act as unique tracers and can provide additional constraints on the regional, hemispheric and global methane budgets. Since no ground-based infrared solar observations have been exploited thus far to retrieve heavy methane concentrations, the first objective is to develop a retrieval strategy for these species from observations collected at three complementary sites member of the Network for Detection of Atmospheric Composition Change (NDACC): Eureka (Arctic, Canada), Jungfraujoch (Swiss Alps) and Toronto (ON, Canada); later applicable to the whole network. Satellite observations from the Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS) providing high vertical resolution and broad spatial coverage will also be included as well as spectra from a portable instrument to match future requirements of methane mapping. The proposed project will also include the development of a methane isotopic module for the chemical transport model GEOS-Chem built on the isotopologue properties. The simulation will be compared with produced and available observations and will be evaluated in terms of absolute value, seasonal cycle and trend in parallel with observations. This newly developed module will allow us to provide a spatially global answer to the question of the methane budget. This project thus plays a key role in the highly topical issues of air quality and climate change.

Keywords: atmospheric composition,greenhouse gas,methane,radiative forcing,air quality,isotopologues,ground based observations,fourier transform spectrometer,emissions,sources and sinks,methane budget
Plasmonic-based autOmated lab-on-chip SEnsor for the rapid In-situ Detection of LegiONella (POSEIDON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Spain,Italy,Sweden,Netherlands
Call: Photonics KET (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-01-31
Duration (months): 37.0
Total project cost (EUR): 4068781.0
EU funding (EUR): 4068781.0
Participants: 7
Project status: CLOSED

Legionnaires’ disease is a serious form of pneumonia caused by bacterium Legionella pneumophila, with a case-fatality ratio on the order of 10-15%. L. pneumophila proliferates in aquatic habitats, especially in potable water, air conditioning, hot and cold water systems, cooling towers, evaporative condensers, spa/natural pools. Actually, its detection and monitoring rely on time-consuming protocols (in the order of several days) based on in-vitro selective bacteria culture methods, performed by highly specialized personnel in dedicated laboratories. POSEIDON project targets to change the approach in bacteriological environmental monitoring and in infection risk management by developing a fully automatic and reliable system. Handling of the air/water sample will be designed and integrated in preconditioning system and microfluidic device through which whole bacteria cells will be transported from the sampling module to the sensing plasmonic surface. The complete measure protocol will be integrated and performed according to EU legislation guidelines. Specificity will be ensured by immuno-functionalization of gratings surfaces and enhanced system sensitivity will be granted by the optimization of the optical detection system architecture. Sensors based on Grating Coupled Surface Plasmon Resonance (GC-SPR) in azimuthally rotating configuration have recently proved sensitivity enhancement up to almost two orders of magnitude. Furthermore, the symmetry breaking related to grating rotation allows exploiting the incident polarization, more easily controlled with respect to incidence wavelength and angles interrogation. The prototype will be designed to be integrated in water distribution or HVAC systems in order to demonstrate its feasibility in industrially relevant fields and to open new applications and new market opportunities. POSEIDON project aims to address new solutions in this relevant health and safety societal challenge.

Keywords: legionella pneumophila detection,monitoring,hvac systems,microbiological environmental monitoring,grating coupled surface plasmon resonance,system automation,microfluidics
Net4Mobility: Network of the Marie Skłodowska-Curie Actions National Contact Points (Net4Mobility)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Coordination and support actions
Countries involved: Estonia,Egypt,Iceland,Israel,Argentina,Ireland,Italy,Cyprus,Bulgaria,Romania,Croatia,Türkiye,Greece,Poland,Switzerland
Call: Trans-national cooperation among Marie Skłodowska-Curie National Contact Points (NCP) (H2020-MSCA-NCP-2014, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 1777949.25
EU funding (EUR): 1498353.0
Participants: 15
Project status: CLOSED

The objective of the Net4Mobility project is to facilitate the transnational cooperation between the National Contact Points (NCPs) of the Marie Sklodowska-Curie Actions (MSCA). The project aims to achieve the following two goals: 1) mutual support and thus raising the general standard of applicants (taking into account the diversity of the different actors) 2) to better inform the research and innovation stakeholders on funding possibilities in the MSCA and help them to improve their performance. Thus, ultimately our goal is to support research and innovation. As a synergy effect, the work processes of REA, EC and NCPs will be optimized and more effective. The project will help less experienced NCPs to improve their service so that their beneficiaries become more competitive. Less experienced NCPs shall be able to rapidly acquire knowledge from the community of MSCA NCPs. Net4Mobility has to raise awareness of MSCA funding possibilities in the non-academic and the academic sectors, especially for the new funding schemes or new modes in existing ones. The project will achieve these goals by the implementation of a wide array of measures, e.g.: - Trainings based on the needs of MSCA NCPs in particular with regards to the challenges of Horizion2020 - 'Twinning' visits and Best Practice Meetings to tap into the already existing knowledge of MSCA NCPs - Communication platforms for the constant exchange and transfer of knowledge A number of public engagement activities and networking events with relevant stakeholders round up the project's activities. Net4Mobility relates to the Work Programme for MSCA 2014-2015 ‘Call for Transnational cooperation among Marie Skłodowska-Curie National Contact Points (NCP)’. The activities are tailored according to the nature of the area and the priorities of the involved NCPs according to the EC Guide on the NCPs principles for H2020

Keywords: national contact points,networking,training,capacity building,development,raising awareness of msca,ameliorating quality of msca proposals
Advanced tools for fighting oNline Illegal TrAfficking (ANITA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Spain,Italy,Italy,Serbia,Belgium,Bulgaria,Poland,Belgium,Greece,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Technologies for prevention, investigation, and mitigation in the context of fight against crime and terrorism (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 4999580.0
EU funding (EUR): 4999580.0
Participants: 18
Project status: CLOSED

ANITA will design and develop a novel knowledge-based user-centred investigation system for analysing heterogeneous (text, audio, video, image) online (Surface Web, Deep Web, DarkNet) and offline content for fighting illegal trafficking of drugs, counterfeit medicines, NPS and firearms. ANITA will combine a) innovative data source analysis of crypto-currency network and transactions and blockchain technologies; b) advanced Big Data analytics tools for automatic analysis of the vast amounts of multimodal content of the identified sources; c) sophisticated methodologies for capturing, modelling and inferring knowledge in human understandable forms (e.g. expressive ontologies), extracting also relevant and new knowledge from neural networks and formally storing it in the form of ontologies; d) development of an adaptive, cognitive user modelling framework that will capture, analyse, interpret, mimic and integrate key human cognitive and information processing functions for: i) incarnating the incorporation of human perception/cognition principles in the system processing pipelines (i.e. integrating the investigators ‘in-the-loop’ of the overall analysis process) and ii) facilitate the transfer of domain knowledge from the expert users to the novice ones; e) domain-related and user-oriented intelligence applications, which will enable users to identify patterns for spatial, temporal and causal correlations among illegal trafficking events, entities and activities and to support decision-making processes for countermeasures to undertake. All the above functionalities will be coupled and reinforced by an in-depth interdisciplinary analysis of the online illegal trafficking phenomenon (including the study of reaction strategies and countermeasures) and a thorough analysis of the online resources with respect to social, ethical, legal and privacy issues of concern. The proposed system capabilities will be demonstrated in multiple relevant operational environments.

Keywords: fight against illegal trafficking,blockchain analysis,user feedback,deep learning representations,big data analytics