Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Early Peopling of Amazonia and the Beginning of Plant Domestication (EPP-Am)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This project investigates two relevant, inter-related and multi-disciplinary topics in the prehistory of the Neotropic: 1) the social-ecological dynamics of earliest people of SW Amazonia and 2) the role these early Holocene populations played in the domestication of Neotropical plants. Genetic studies suggest that SW Amazonia, and in particular the Llanos de Moxos in Bolivia, is a region where important Amazonian crops were domesticated, including manioc, peanut, peach palm, jack bean and two varieties of chili pepper. However, genetic evidence has not been substantiated by archaeology as yet, due to the virtual absence of early sites in the region. The applicant’s recent discovery of early Holocene shell-middens in the area and the application of state-of-the-art multi-proxy techniques offer a unique opportunity to provide archaeological evidence for plant exploitation trajectories. Six early sites, and their local environments, are going to be studied for the first time through a focus on socio-ecological interactions and plant management strategies. The proposal is a fundamental step in the applicant’s career as he will be able to dramatically improve his technical skills in several archaeological techniques (phytoliths, starch, micromorphology, shell middens excavation). The research will also enhance the candidate's capabilities to integrate palaeoecological and archaeological evidence, a decisive move to promote his scientific leadership and career development.

Keywords: ancient diet,plant domestication
MANGO: exploring Manycore Architectures for Next-GeneratiOn HPC systems (MANGO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Spain,Switzerland,Croatia,France,France,Netherlands
Call: HPC Core Technologies, Programming Environments and Algorithms for Extreme Parallelism and Extreme Data Applications (H2020-FETHPC-2014, 2014)
Start date: 2015-10-01
End date: 2019-03-31
Duration (months): 42.0
Total project cost (EUR): 5801820.0
EU funding (EUR): 5801820.0
Participants: 10
Project status: CLOSED

MANGO targets to achieve extreme resource efficiency in future QoS-sensitive HPC through ambitious cross-boundary architecture exploration for performance/power/predictability (PPP) based on the definition of new-generation high-performance, power-efficient, heterogeneous architectures with native mechanisms for isolation and quality-of-service, and an innovative two-phase passive cooling system. Its disruptive approach will involve many interrelated mechanisms at various architectural levels, including heterogeneous computing cores, memory architectures, interconnects, run-time resource management, power monitoring and cooling, to the programming models. The system architecture will be inherently heterogeneous as an enabler for efficiency and application-based customization, where general-purpose compute nodes (GN) are intertwined with heterogeneous acceleration nodes (HN), linked by an across-boundary homogeneous interconnect. It will provide guarantees for predictability, bandwidth and latency for the whole HN node infrastructure, allowing dynamic adaptation to applications. MANGO will develop a toolset for PPP and explore holistic pro-active thermal and power management for energy optimization including chip, board and rack cooling levels, creating a hitherto inexistent link between HW and SW effects at all layers. Project will build an effective large-scale emulation platform. The architecture will be validated through noticeable examples of application with QoS and high-performance requirements. Ultimately, the combined interplay of the multi-level innovative solutions brought by MANGO will result in a new positioning in the PPP space, ensuring sustainable performance as high as 100 PFLOPS for the realistic levels of power consumption (<15MWatt) delivered to QoS-sensitive applications in large-scale capacity computing scenarios providing essential building blocks at the architectural level enabling the full realization of the ETP4HPC strategic research agenda

Keywords: real time hpc,power performance predictability,capacity computing,partitionability,reconfigurability
Tissue regeneration and aging: the decisive quiescent stem-cell state (STEM-AGING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain,Spain
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 2499949.0
EU funding (EUR): 1251824.0
Participants: 2
Project status: CLOSED

The basic mechanisms of stem cell malfunction during aging are poorly understood even though they underlie the regenerative decline of most organs and tissues as we age. Based on our recent contributions (Nature 2014, Nature 2016), the fields of tissue regeneration and aging converge on the key role of the quiescent state, the preferred state of stem cells in low turnover tissues such as skeletal muscle. Our unifying hypothesis is that stem-cell quiescence maintenance, which requires active proteostasis (protein homeostasis), lies at the basis of stemness, and that its substitution by a senescence state in aging impairs regeneration. How these variables connect to drive stem cell aging is not known. Crucial experimental systems in this proposal are sensitive reporter mice for proteostasis, senescence and quiescence/fate in aging muscle stem cells. The project is divided as follows: Objective 1. Proteostasis and stem cell quiescence maintenance: tracing proteostasis in quiescent stem cells from autophagy and chaperone-mediated autophagy (CMA) reporter mice during aging / impact of autophagy/CMA loss on quiescence and regeneration / molecular regulators of proteostasis. Objective 2. Proteostasis and quiescent stem cell heterogeneity and fate: asymmetric segregation of proteotoxic waste as an instructor of stem cell heterogeneity and regenerative fate. Objective 3. The quiescence-to-senescence-switch in aging muscle stem cells: tracing and isolating senescent stem cells in senescence-cell reporter mice during aging / impact of senescent cell ablation on regenerating aged muscle. Objective 4. Circadian regulation in the quiescent stem-cell state: impact of aging on circadian rhythms and consequences for quiescence maintenance and regeneration. We expect that completion of these objectives will provide new fundamental knowledge on stem-cell biology, regeneration and aging.

Keywords: tissue regeneration,stem cells,skeletal muscle,senescence,proteostasis
Dynamical Phenomena in Quantum Many-Body Systems (QMBDyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

We will study dynamical phenomena in strongly interacting quantum systems, which currently receive increased attention due to recent experimental, numerical and theoretical breakthroughs. Our research will push the limits of the state of the art of numerical simulations in this context by bringing together experts (the ER and the host group) on different aspects of this topic in an outstanding research environment in Munich with an excellent infrastructure and a clustering of theoretical and experimental groups with the potential to world class collaborations. Our research will gravitate around the important question of the mechanism of thermalization (and its absence) in isolated quantum systems and tackle outstanding questions, such as the existence of many-body localization (MBL) in higher dimensions and the nature of anomalous thermalization in subdiffusive systems. The focus of this project is the study of the MBL transition, which is a dynamical phase transition driven by disorder, separating disordered correlated systems in a thermal, metallic phase and a localized, insulating and non-ergodic phase, depending on the strength of the disorder. Our detailed numerical transition will help to obtain a deeper understanding of the MBL transition and of states with localization protected quantum order. We will also study systems with time dependent Hamiltonians, most importantly those with a periodic time dependence (Floquet systems), which have been shown to exhibit fascinating phenomena such as a spontaneous breaking of time translation symmetry in Floquet time crystals and will aim to discover new types of time order in these systems. The timeliness and expected outstanding quality of our results will establish the ER as a leader in the field of numerical studies of dynamical strongly correlated systems and the environment in Munich will make him highly visible in an international context, greatly enhancing his leadership skills and career perspective.

Keywords: many body localization mbl,eigenstate thermalization hypothesis eth,floquet,driven quantum systems,dmrg,matrix product states mps,exact diagonalization,quantum monte carlo,nonequilibrium
An integrative approach for the exploration of melanoma genetic and immunological interactions (MEL-Interactions)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Tumor development emerges from an accumulation of somatic alterations that together enable malignant growth. These alterations are immensely diverse and the fate of a cell acquiring an alteration may depend on other alterations already present. Despite our progress in mapping the cancer genetic landscape and an expanding catalogue of cancer genes, a need arises to establish how alterations in cancer genes interact to transform healthy cells into cancer cells. Many fundamental questions regarding genomic interactions remain open. For example, we do not know which proteins make up signaling pathway hubs and in which genetic contexts, how genetic alterations interact functionally, how cancer genetic alterations influence the interaction with T cells and how these affect patient response to therapy. The recent growth in the number of genomics data sets gives rise to a parallel increase in statistical power to detect more complex associations allowing robust analyses of complex interrelated genomic networks. In this proposal we suggest to employ our expertise and unique toolsets, to shed new light on the complex interrelated networks formed in melanoma. We propose to combine state-of-the art high content tools with mechanistic studies to discover the structure of signaling-hub organization in melanoma (Aim 1), functionally characterize the complex genetic interactions within the melanoma genome using genome engineering approaches (Aim 2), and to decipher the immuno-genetic interactions between melanoma and T cells (Aim 3). Importantly, we will try to bridge the knowledge gap in deciphering melanoma-specific gene interactions, protein interactions and interactions with T cells by creating new tools and experimental models. Our findings should make an important step towards an unprecedented, thorough and multifaceted understanding of melanoma biology. More broadly, we believe these approaches provide a paradigm for addressing similarly complex questions in other cancers.

Keywords: cancer genetics,somatic mutation,sequencing,targeted therapy,signal transduction
I4MS Going to Market Alliance (I4MS-Go)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Poland,Denmark,Denmark
Call: ICT Innovation for Manufacturing SMEs (I4MS) (H2020-FOF-2017, 2017)
Start date: 2017-09-01
End date: 2020-02-29
Duration (months): 30.0
Total project cost (EUR): 992283.75
EU funding (EUR): 992283.75
Participants: 6
Project status: CLOSED

The I4MS Going to Market Alliance (I4MS-Go) will bring the I4MS innovation ecosystem to the market by creating the largest on-line community of stakeholders, users and service providers, for the digital transformation of manufacturing SMEs and Mid-Caps to a profiled audience of 2 million impacts. This will be achieved by the clustering of 11+ I4MS Innovation Actions; the mobilization of 7 M€ of additional public (ESIF) and private Funding though I4MS-Regions, the I4MS Disruptors Awards and I4MS-Accelerate and the implementation of the I4MS-Skills Observatory under the framework of the Digital Skills and Jobs Coalition; MADE, recognized by the EC as a best practice example of support to advanced manufacturing at EU level, and active member of EFFRA, will lead the clustering of all I4MS Innovation Actions and the Top-100 European Digital Innovation Hubs, whilst FIWARE FOUNDATION, will lead the liaison with all DSM initiatives. MWC, organizer of the world´s largest event for Digital Industries, and promoter of the Going Digital Initiative, will position I4MS and the Skills Observatory globally as the biggest and most influential ecosystem for Digitisation of manufacturing SMEs. FBOX, coordinator of the FIWARE Accelerator IMPACT Growth and partner of 4 piloting DIH supported by I4MS, will manage the on-line community for newcomers and existing stakeholders of the I4MS ecosystem. The Galician Innovation Agency (GAIN), coordinator of the MONITORIS3 project, the INCOMERA ERA-NET Cofund project and a RIS3 best practice itself, will create the proper liaison with the Smart Specialization Platform and the ERA-LEARN 2020 CSA to leverage further investments following multi-regional collaboration models. I4MS-Go will demonstrate how an EC funded CSA can broader an ecosystem for European manufacturing that helps turn the EU into the “EU of entrepreneurial states and digital industries".

Keywords: factories of the future,4 0 industry,smart anything everywhere,crowdfunding,skills
Solidarity in Diversity (SOLiDi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Ireland,Germany,Malta,Belgium,Sweden,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 4033976.04
EU funding (EUR): 4033976.04
Participants: 10
Project status: SIGNED

Over the last decade, liberal democracies in Europe have been shaken to their core by the rise of national populisms. This puts strong pressure on all forms of solidarity, especially as they cross ethnic-cultural boundaries. The increasingly successful capture of the notion of solidarity by radical right, anti-liberal democratic forces is testimony to this. The challenge for European democracies is to identify the conditions under which solidarities in diversity can be nurtured. To address this urgent challenge, the European Training Network “Solidarity in Diversity” (SOLiDi) develops a training and research program that is focused on how to generate solidarities across cultural boundaries, taking the proximity of citizens with different ethnic-cultural backgrounds in specific places and the practices they engage in as starting point. Building on the strengths of the interculturalist paradigm, SOLiDi will originally contribute with an intersectional understanding of how place-based solidarity practices are shaped by and can work around entrenched social inequalities and unequal power relations. To that end, SOLiDi brings together a group of international scholars from sociology, geography and educational science and a wide range of non-academic partners that are active in different sectors. SOLiDi will train 15 early stage researchers in relevant theories, research methods and ethics and paradigms of social change such as public pedagogy and policy and organisational change to study practices of place-based solidarities in diversity in different geographical, policy and organisational contexts. The aim is to articulate a new vision on solidarity adapted to superdiverse societies and to better equip professionals and organisations with adequate and innovative tools for facilitating solidarity in diversity. SOLiDi aims are in line with SDG10 “Reduced Inequalities” and Societal Challenge 6 ‘Europe in a changing world - Inclusive, innovative and reflective societies’.

Keywords: solidarity,diversity,intersectionality,public pedagogy,qualitative research,place,social innovation,policy,organisational change
Support to the coordination of national research and innovation programmes in areas of activities of the European Energy Research Alliance (SUPEERA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Germany,Norway,Finland,Belgium,France,Denmark
Call: Support to the coordination of national research and innovation programmes in the areas of activities of the European Energy Research Alliance (EERA) (H2020-IBA-SC3-EERA-2018-3, 2018)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 1669999.37
EU funding (EUR): 1669999.37
Participants: 6
Project status: SIGNED

The SUPEERA project supports the implementation of the SET-Plan. Since the SET-Plan does not yet have a mechanism for using cross-cutting research capacities or pooling interdisciplinary activities, SUPEERA will improve the exchange of information between the Implementation Working Groups and make recommendations for joint actions. SUPEERA will also help to accelerate the uptake of new technologies by industry and to examine the impact of EU policies in the view of bringing the SET-Plan forward in the broader context of the Clean Energy Transition.

Keywords: set plan,set plan implementation plan,implementation working group,eera,clean energy transition,accelerating innovation,transfer to industry,indicators,policy translation
Behavioral and neural determinants of metacognition and self-awareness in human adults and infants (METAWARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France,Denmark
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-02-01
End date: 2021-01-31
Duration (months): 60.0
Total project cost (EUR): 1981338.0
EU funding (EUR): 1761338.0
Participants: 3
Project status: CLOSED

Proposal summary. Understanding the psychological and neurobiological determinants of consciousness is fundamental. Yet, the main trend focusing on how the front of the brain (prefrontal cortex) interacts with the back (sensory cortex) for accessing perceptual contents limits our understanding of the information coding schemas underlying consciousness. Here, we explore these informational properties in adults and infants from 3 novel perspectives: sleep, self-consciousness and metacognition. First, we will study unconscious processes in the full absence of consciousness, including self-consciousness and metacognition, by focusing on the sleeping brain’s ability to process and learn information from its environment. While most studies on subliminal perception measured unconscious processes intermixed with conscious ones, studying their impact in the sleeping brain will provide new insights on a broader and more natural type of unconscious. Secondly, we will explore the fundamental issue of whether multiple agents can share information and each other’s conscious access mechanisms, without being aware of it. Using a novel approach called the “Reversed Perspective Paradigm”, we will study if access to conscious content can be determined by another agent’s actions and sensory processing while the agent is lured to believe she owns these access mechanisms. We aim at challenging the long-held conviction that consciousness is a paradigm of privacy, by breaking it using virtual reality and objective methods from psychology. Finally, we will attempt to answer the two fundamental issues of whether infants have a capacity for metacognition (do they know they know) and whether they experience self-consciousness (do they feel themselves as a unitary entity). Examining these self-reflection mechanisms, through behavioural and EEG techniques, will address the issue of whether humans in the initial state have a primitive self, or are actually unconscious about their own person.