Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evaluation and Manipulation of the Mechanisms and Interactions of Protein-Carbohydrates-Ingredients for Formulating Novel Plant-Based Cheese (NovelPBC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-01-31
Duration (months): 28.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

Today, there is a considerable desire to consume sustainable products due to healthy and ethical reasons, environmental sustainability, and issues related to greenhouse gas emissions. Ireland now specializes in producing beef, lamb, and dairy—which are the most emission-intensive foods—but plans to cut greenhouse emissions (50%) by 2030 and reach net zero emissions by 2050. Cheese manufacturing consumes significant quantities of energy (4.9-8.9 MJ/kg) and the study on the novel dairy-free cheeses has gained high interest due to the new opportunities offered by the worldwide market where it is predicted to rise to 3.90 billion USD by 2024. The dairy-free industry faces major challenges to formulate dairy-free cheeses with excellent nutritional properties, functionality, flavour, and texture—compared with the dairy-based cheeses. This study proposes to evaluate and manipulate interactions of plant proteins/carbohydrates/relevant ingredients through food material science, aiming to design an innovative dairy-free cheese with similar physicochemical, rheological, and sensory properties to the dairy-based cheese. This project will be carried out during a 2-year period at Teagasc with a 3-month secondment in University College Cork. Firstly, the physico-chemical interactions, structures and functional properties of materials will be studied and the most appropriate materials and their ranges will be determined (WP1). After producing some prototypes of dairy-free cheeses, the properties of them will be determined (WP2), and then, formulation(s) will be optimized (WP3). Finally, the quality of the optimized sample will be compared with commercially available cheeses (WP4). Results of this study will contribute to the industrial/sustainable production of dairy-free cheeses; thus, it will provide food security, sustainable lifestyles, and consumption patterns in alignment with current Teagasc goals, Horizon 2022, EU, and Irish government research initiatives.

Keywords: dairy free cheese structures formulation plant proteins bioactive compound rheological properties,physicochemical properties
Rationale design of sustainable porous organosilicas for optimal CO2 uptake from biogas (GRACE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal,Norway,Iceland
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-03-01
End date: 2025-08-31
Duration (months): 30.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 3
Project status: SIGNED

Biogas is a renewable energy source that contributes to carbon-neutrality by reducing GHG emissions. An EU-wide climate policy framework supports a circular economy based on biomethane. Yet, biomethane is largely contaminated with CO2 that must be removed. A promising method for biogas upgrading benefits from the use of solid adsorbents, cutting down 40% in sorbent regeneration costs compared to the use of decades-old liquid amine absorbents, which suffers from poor chemical stability and high regeneration energy costs. How can GRACE contribute to the global effort towards the design of future-generation sorbents with improved CO2/CH4 separation? GRACE aims at providing answers to this end by rationale materials’ design that will help to build an atomic-level understanding of intermolecular interactions at the gas-solid interface governing thermodynamic/kinetic phenomena at sorbent surfaces. The scarcity of atomic-scale studies in gas-sorption mechanisms at porous surfaces has hindered further progresses on the synthesis of better CO2-adsorbent materials. This knowledge gap is thus my major motivation. To tackle this challenge, GRACE encompasses 3 main goals: 1) design sustainable periodic mesoporous organosilica (PMO) sorbents; 2) obtain structure-property relationships studying gas-sorbents at the atomic level; 3) test distinct PMO grain shapes for better biogas upgrading under industrially-relevant operating conditions. My past expertise in materials’ design and multidisciplinary characterization skills will be a valuable asset not only for the synthesis of viable sorbents with favorable properties for CO2/CH4 separation but also for the tandem use of operando TGA-IR, NMR/DNP spectroscopies and gas adsorption to study confined 13C-enriched CO2 species (using pure CO2 or gas mixtures). This equipment is hosted at CICECO-UAVR, an internationally renowned lab that fosters interdisciplinary research and is committed to support the growth of young researchers.

Keywords: periodic mesoporous organosilicas,co2 ch4 adsorption separation
Disruptive Therapies for the long-term relief of Osteoarthritis Pain (Arth-Alleve)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1998885.0
EU funding (EUR): 1998885.0
Participants: 1
Project status: SIGNED

Osteoarthritis (OA) is the most common cause of chronic pain in older persons in Europe and is the leading cause of disability. The disease is a condition affecting the joint cartilage and subchondral bone and is frequently accompanied by pain, stiffness, and long-term disability. Chronic pain is the most prominent symptom in most people with OA, and is the most important determinant of disability in patients with osteoarthritis. Treatment guidelines for OA pain management uniformly recommends a range of pharmacological therapies, including paracetamol, NSAIDs and opioids, together with non-pharmacological therapies. However, such therapies are restricted by considerable side effects and limited efficacy, as well as country-specific restrictions on prescriptions (e.g. on opioid use). Given the risks and side effects associated with current therapies, the long-term outlook for OA patients is bleak. Currently there exists no non-pharm effective therapy for OA pain management. OA patients are left with two options: Manage the debilitating chronic pain using over-the-counter and/or prescription medication, with all of the risk and side effects associated with those therapies; or try to independently cope with the pain and all of the personal, economic and societal challenges that chronic pain presented. Within the ambitious Arth-alleve project, we propose to develop a non-pharma side-effect-free long-term therapy for OA patients, providing new hope to the growing cohort of European citizens affected by this debilitating disease. The Arth-Alleve project will explore the concept of attaching neurotoxin molecules to hydrogel particles, to enable the mechanism of nerve blocking to occur, with the hydrogel acting as a long-term anchor preventing migration of the molecule from the target site. This project will truly transform the treatment of chronic OA pain, and the Quality of Life of the large cohort of European patients suffering from the condition.
Multiplying feasible microalgae-derived products at scale (MULTIPLY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Portugal,Sweden,Denmark,Spain,Germany,France,Belgium,Italy,Norway,Luxembourg
Call: Sustainable micro-algae as feedstock for innovative, added-value applications (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 9668466.25
EU funding (EUR): 7450981.75
Participants: 17
Project status: SIGNED

Microalgae biomass holds a great potential to become the reference source of sustainable ingredients for a broad range of bio-based industries. However, it is still an underexploited feedstock in Europe, mostly used to produce low volume/high value products, due to lack of cost-competitive technological solutions for cultivation and biorefinery processes. MULTIPLY aims to demonstrate economically feasible and environmentally sustainable microalgae cultivation and biorefinery processes, for the provision of valuable algal ingredients, suited for the formulation of mid-price products for the food, feed, biomaterials, lubricants and cosmetics sectors. By enhancing and upscaling efficient, innovative and green technologies for the main steps of microalgae cultivation and downstream processing, implementing circular economy approaches and incorporating advanced monitoring and digital tools, MULTIPLY will increase productivity, reduce the use of resources and associated costs and improve the environmental performance of the processes. Based on 5 microalgae species, MULTIPLY will deliver 10 products of improved environmental impact, meeting market requirements. Led by the industry and backed up on institutes and universities of excellence, MULTIPLY brings together microalgae primary producers from southern and northern Europe, technology developers, researchers and industrial end-users of algae ingredients. A strong dissemination, communication and exploitation strategy will ensure an effective uptake of the project results, enabled by a better understanding of the social acceptance drivers and stimulating the enhanced public acceptance for algae-based products and processes. MULTIPLY will create new value chains, paving the way for the deployment of a sustainable, circular and digital microalgae industry in Europe.

Keywords: microalgae biorefinery food and feed nutrient upcycling
Intergenerational Open Geospatial Carbon Registry - Open-Source Tools for Connecting EU Agricultural Policies (CAP) and Carbon Removals and Carbon Farming (CRCF) Regulation to national inventories and carbon markets (OGCR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Netherlands,Switzerland,Finland,Austria,Canada,Belgium,Germany,Greece,Romania,Italy,Poland,Czechia,Hungary,France,Latvia,Portugal,United Kingdom,Croatia,Serbia
Call: Development of high spatial-resolution monitoring approaches and geographically-explicit registry for carbon farming (HORIZON-MISS-2024-SOIL-01, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 11499995.0
EU funding (EUR): 11499995.0
Participants: 31
Project status: SIGNED

The Intergenerational Open Geospatial Carbon Registry (OGCR) aims to create: 1) updateable baseline geospatial layers for soil, biomass and peat for pan-EU, 2) a hybrid modelling framework to explore management changes in CAP and CRCF initiatives, and 3) a globally applicable open geospatial carbon registry, servicing pan-EU. We will use a genuinely transparent stakeholder co-design & consultative development process to build software interfacing between CRCF and CAP activities with mandatory and voluntary markets. Above and below ground carbon reduction and farming activities will be measured, monitored and independently verified. The system will attract both small and big landholder participation through 1) an innovative geospatial carbon accountancy framework that fairly rewards landholders for avoiding and sequestering carbon over generations, 2) applicability to all lands independent of management, and 3) easy access to geospatial information on past, present and possible future states for soil carbon, biomass and peat soils under different managements. Geospatial hazards and risks, including those related to climate change, will be scientifically based and user accessible. Economic and environmental impact evaluations will be widely available to aid landholders and project developers to assess potential for entering the nascent EU CRCF markets. OGCR will rely on an underlying statistical unification of common MRV approaches, both direct measurement, modelled and hybrid approaches, through their uncertainty metrics; and on a socially responsible and ecologically valid economic framework for their temporal valuation through time. OGCR will be built in the open view of the stakeholder community by the open source community, under scientific supervision and iteratively developed. OGCR will be free and clear of any restrictive copyright for claims, licensed under permissive Creative Commons licenses and connected to vendored services in a free-market dynamic.

Keywords: carbon registry,soil,accountancy,geospatial,open source,co design,transparency,reproducible science,fair and care principles,lulucf,crcf,eu ets
Microfluidics-assisted synthesis of Dapagliflozin-loaded liposomes for heart fibrosis: Development of a 3D bioprinted multicellular in vitro model (SAVETHEHEART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-15
End date: 2026-09-14
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, with half of CVDs deaths being caused by coronary artery disease. Myocardial infarction is the most common cause of cardiac insufficiency, leading to fibrosis and ultimately heart failure. Since current therapies for cardiac fibrosis have limitations, there is a need for more effective strategies. Gliflozins (e.g., Dapagliflozin and Empagliflozin), hypoglycemic agents and SGLT2 inhibitors usually used for the treatment of type 2 diabetes, have been shown in recent clinical trials (i.e., DAPA-HF, DELIVER, EMPEROR-Reduced, EMPEROR-Preserved) to reduce the combined risk of cardiovascular death or hospitalization for heart failure in patients with reduced and preserved ejection fraction, regardless of diabetes status. They have also been shown to ameliorate myocardial fibrosis post-ischemia. Nevertheless, most of the underlying mechanisms of these benefits remain elusive and the potential adverse effects of the systemic administration of gliflozins must be recognised. In this regard, the use of liposomes as in situ injectable drug delivery systems offers many potential advantages for the therapy of myocardial infarction. Therefore, the SAVETHEHEART project aims to develop a new therapeutic approach for the efficient treatment of cardiac fibrosis by using liposomes, produced by microfluidics to encapsulate Dapagliflozin (DAPA). Their effect will be studied in a 3D model of cardiac fibrosis, that will be obtained by bioprinting a biomimetic type I collagen hydrogel, bioengineered with human induced pluripotent stem cells-derived cardiomyocytes, myofibroblasts and endothelial cells, and cultured under perfusion and hypoxic conditions to better mimic a fibrotic response. Understanding cell behaviour in the proposed setting, this work opens perspective to the optimization of injectable DAPA-liposome formulations, intended as an innovative therapeutic strategy for the treatment of cardiac fibrosis.

Keywords: microfluidics,liposomes,dapagliflozin,bioprinting,multicellular 3d in vitro models,human primary cells,perfusion bioreactor,hypoxia,myocardial infarction,cardiac fibrosis,tissue engineering
Unravelling the behaviour of inorganic (nano)phases in leaves to optimize the foliar delivery of sustainable agrochemicals (LEAPHY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1684046.0
EU funding (EUR): 1684046.0
Participants: 1
Project status: SIGNED

Population growth and the expected-to-increase (a)biotic stresses due to climate change are putting the agro-ecosystems under pressure. The dependence on inorganic agrochemicals (IAs) for fertilization and plant protection will lead to an increase in their use. Yet, current IAs do not efficiently reach their target. They lead to waste of resources, pollutions, and environmental degradations. Foliar application of nanostructures is one of the proposed solutions to optimize IAs in order to better protect crops, but also their agro-ecosystem. Nano-IAs can exhibit reduced leaf leaching and increased bioavailability, allowing to strictly apply the right dose of IA. However, the lack of knowledge on IA behaviour at the leaf interface hinders our ability to predict optimized nanostructures. The LEAPHY project aims to establish a rationale for the design of such nano-IAs. Model nano-IAs with controlled morphologies and surface properties will be designed and exposed to isolated plant cells or model leaves characterized for their surface characteristics and interfacial functional groups. The pathways and associated rates of uptake, transformations, and in planta behaviour will be quantified. These results will be used to establish a predictive modelling framework for the biological and chemical interactions that govern IA adhesion, uptake, and translocation from leaves to other plant tissues and organs. This knowledge will be leveraged to design and test bio- and geo-inspired copper-based fertilizers and pesticides with improved delivery efficacy. The team's expertise in tuning (in)organic reactivity at plant interfaces and studying the resulting interactions and speciation changes is the backbone of LEAPHY's state-of-the-art experimental strategy. This project will be a cornerstone in implementing solutions to contribute to building a rationale for safe foliar phytoprotection and fertilization strategies.

Keywords: nano bio interface speciation copper agrochemicals plant biological barriers inorganic reactivity cellular intake nanoparticles fertilizer pesticide impacts
Promoting and Incentivising Federated, Trusted, and Fair Sharing and Trading of Interoperable Data ASsets (PISTIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Germany,Spain,Belgium,Cyprus,Netherlands,Italy,Greece,Austria,United Kingdom,Ireland
Call: Technologies and solutions for data trading, monetizing, exchange and interoperability (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 14932957.5
EU funding (EUR): 11945613.5
Participants: 31
Project status: SIGNED

PISTIS brings forward a reference federated data sharing/trading and monetisation platform for secure, trusted and controlled exchange and usage of proprietary data assets and data-driven intelligence. PISTIS will advance the available techniques and technologies, such as federated data discovery and sharing, DLTs, data non-fungible tokens (NFTs), AI-driven data quality assessment and monetisation, to build trust among stakeholders and assuage their concerns. Such stakeholders will formulate a distributed network of existing and new data spaces with built-in governance brought by PISTIS to eliminate silos while accruing the actual data value and multiplying it through derivative assets in a fair and transparent manner. Taking into consideration the data supply and demand perspectives, PISTIS will establish the methodological and technical foundations across different axes: -PISTIS Federated Data Management, Interoperability & Governance that aims at collecting, curating, securing and fully controlling the data made available through each organisation’s data space. -PISTIS Federated, Secure Data Sharing that concerns the effective management and on-chain storage of (multi-party) data contracts in an inherently human-understandable manner, as well as the secure peer-to-peer data transfer and usage monitoring mechanisms for appropriately retrieving, provisioning, self-serving on-demand and tracking the appropriate data ‘slices’ according to the relevant contract provisions. -PISTIS Data Valuation and Monetisation to systematically articulate and recommend an appropriate target value, indicatively taking into consideration the “cost” approach, the “income” approach, and the “market” approach. -PISTIS Data Sharing Skills Cultivation that provides the training material to educate stakeholders into how they can assess their data sharing maturity, proceed with data, deploy/operate the PISTIS technologies and implement an effective and sustainable data sharing strategy.

Keywords: data quality,quality assessment,data pricing,monetisation,data sharing,data trading,trust,security,nfts,blockchain,living lab