Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Placenta-expanded adherent stromal cells (PLX-PAD) as an innovative therapy for improving recovery and survival following hip fracture arthroplasty – HIPGEN, a multicenter phase III trial (HIPGEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Israel,Italy,Germany,Italy,Switzerland,Türkiye,Czechia,United States,United Kingdom,United Kingdom,Denmark
Call: Clinical research on regenerative medicine (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2022-09-30
Duration (months): 57.0
Total project cost (EUR): 7437127.5
EU funding (EUR): 7437127.5
Participants: 17
Project status: CLOSED

Aim of the HIPGEN project is to develop the first cell therapy to improve functional recovery following hip fracture arthroplasty. Hip fractures are a major public health concern in the EU with an increasing incidence of 1 million patients per year, high direct and indirect costs and high mortality. Conventional therapies are not able to address the main medical problems of hip fracture in these elderly patients, being the impairment of mobility and the stress imposed as a combined result of injury, surgery and immobilisation. PLX-PAD are an allogeneic, placental-derived, stromal cell product and currently the only Advanced Therapy Medicinal Product (ATMP) in phase III in this indication. Based on comprehensive preclinical work on the effect of PLX-PAD on muscle regeneration after injury, a phase I/II study under the collaboration of Pluristem and Charité demonstrated an increase in muscle force and volume in hip arthroplasty patients and a reduction of early postoperative stress. We plan to conduct a multicentre, randomised, double blind, placebo controlled phase III clinical trial evaluating the efficacy of intraoperative intramuscular injections of PLX-PAD for the recovery of hip fracture patients. The clinical study will include biomechanical analyses and in-depth biomarker studies of treated patients analysing the effects of the cells on the immune system and individual stress reactions aiming at stratifying patients in future therapies. Further preclinical characterisation of the mechanisms of action of PLX-PAD in injured patients will be conducted. The “Be the Partner” platform will be used to improve patient experience in the trial, and create a strategic patient engagement beyond the trial. In addition to renown experts in hip fracture, cell therapy and immunology, our consortium includes the main organisation for osteoporosis, IOF, who will help disseminate and communicate the results of the phase III study among clinicians and patient organisations.

Keywords: phase iii clinical study,hip fracture recovery,cell therapy,ex vivo expanded placental cells,muscle regeneration,orthopaedic surgery,trauma
Creating high impact for CAPS (ChiC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Greece,Switzerland
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-06-01
End date: 2019-01-31
Duration (months): 32.0
Total project cost (EUR): 1214625.0
EU funding (EUR): 677125.0
Participants: 3
Project status: CLOSED

ChiC is a game-changing Coordination and Support Action aiming at maximizing the impact of the ICT-10 2015 projects and transforming CAPS in an Innovation Ecosystem. The consortium brings together well-experienced partners which can count on the lessons learned and the network acquired in on-going FP7 CSAs (in the CAPS field and beyond): this sound foundation will make us move the CAPS Programme one step further from day 1. In the last couple of years, CAPS-centered projects and initiatives have been successfully initiated and pursued by an increasing number of innovative and diverse players, including industry, academia local communities, grassroots activists, hackers, social entrepreneurs, students, citizens, creative industries and civil society organizations. There is a strong need to coordinate these efforts so as to maximize their impact for the whole European society. This is where the Creating high impact for CAPS (ChiC proposal comes with the ambition to act as a bridge between all CAPS-driven efforts and players, including the EC representative and related EU initiatives. ChiC is an ambitious 30 months CSA that groups a small, but very dynamic team of well-experienced players in the CAPS and related domains, which are committed to create broad impact on the basis of a well-structured and articulated work plan. ChiC will coordinate and support experimental and scientific efforts within the CAPS context to maximise their impacts and reach beyond current players for effective involvement and engagement of new stakeholders. The ambition of ChiC is to support the various CAPS and related projects by offering them concrete opportunities for networking, know-how sharing/exchange and effective promotion of their work and result, but also to ensure that the CAPS programme as a whole can grow as a unique, engaging and disruptive initiative.

Keywords: caps,accelerator,innovation ecosystems
Origins of trait diversity in flowering plants: understanding interactions between plant defence and pollination using molecular, phenotypic and ecological studies of natural selection (DEFPOLL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The extraordinary diversity of flowering plants is arguably most evident in two seemingly unrelated aspects of life history: reproduction, exemplified by the stunning diversity in flower form and function; and defence, exemplified by the remarkable variation in toxic chemistry found in the leaves of most plant species. Despite over 150 years of research on these topics, comparatively few studies have addressed how defence and reproduction interact on ecological and evolutionary time scales. This is surprising, first, because variation in sexual reproduction determines key aspects of plant populations that are known to influence the frequency and impact of antagonists such as herbivores and pathogens; and second, because herbivory and disease are ubiquitous stresses that influence plant reproductive success. Feedbacks between defence and sexual reproduction therefore represent a rich set of unexplored mechanisms explaining important components of plant trait diversity. The objective of this proposal is to address this knowledge gap by answering two questions: First, what are the immediate consequences of a shift in a plant species’ reproductive strategy for interactions with pollinators and herbivores? Second, what are the impacts of these altered species interactions for plant fitness and the evolution of both leaf defence traits and floral pollination traits? To answer these questions, I will gain training in plant molecular biology, allowing me to combine cutting edge genome-editing techniques and gene expression analyses with my own expertise in evolutionary ecology and chemical ecology. With this interdisciplinary approach, I will assess novel genetic and ecological factors underlying variation in defence and pollination phenotypes, two classes of plant traits that are of critical significance in both wild and managed plant species.

Keywords: plant mating systems,plant defence,pollination,herbivory,coevolution,arabidopsis lyrata,self incompatibility,brassicaceae,evolutionary ecology,molecular ecology
Wearable diagnostic for inflammation tracking for personalized patient care among at-risk patients (CytoTrack)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 2509562.5
EU funding (EUR): 1756693.75
Participants: 1
Project status: SIGNED

Xsensio is an innovation-driven Swiss company dedicated to solving one of the biggest challenges for personalized medicine: the lack of real-time, continuous monitoring of health parameters in patients. Xsensio has built the highly modular CytoTrack breakthrough sensing platform to continuously and non-invasively track biochemical information as a wearable system and offer critical health insight in real time. CytoTrack has potential to continuously monitor inflammatory markers that tend to suddenly increase in at-risk patients, when infected by influenza-related viruses (e.g. COVID-19), or when undergoing powerful oncology treatments, exposing them to severe life-threatening organ failure. We have a passionate team of 7 PhDs, engineers and business people with expertise ranging from biochemistry and nanofluidics to data analytics and healthcare marketing, all committed to making the Lab-on-SkinTM a daily reality impacting tomorrow' s healthcare. In 2018, a 2-year agreement was signed with a top 10 biopharma company to leverage our cutting-edge solution for their oncology pipeline. Xsensio received many awards internationally, e.g. CES Innovation Award 2020 given to the world’s best innovations. Xsensio plans to grow a large, successful company, that becomes a European success story. While the preferred exit is an IPO, Xsensio remains open to other opportunities, including a trade sale. The milestones targeted in this proposal are critical to the future of Xsensio: they allow the company to build a strong platform of game-changing complementary diagnostic monitoring for the pharma industry to help predict the likely response and likely severe toxicity of their drugs during drug development and post-market surveillance. Investment from the EIC is critical to Xsensio as efforts to raise funds have proven to be challenging in the absence of preclinical data, putting the validation phase at risk of being delayed. Xsensio welcomes blended finance from the EC.

Keywords: non invasive disease biomarker monitoring in sweat,sensing platform,complementary diagnostic,smart wearable technology,mhealth,lab on chip,patient centric clinical,trials,covid 19
Highly Innovative building control Tools Tackling the energy performance GAP (HIT2GAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Ireland,Germany,Spain,Germany,Spain,Ireland,Italy,Italy,Cyprus,Türkiye,Poland,Greece,France,France,France,United Kingdom,United Kingdom
Call: New tools and methodologies to reduce the gap between predicted and actual energy performances at the level of buildings and blocks of buildings (H2020-EeB-2015, 2015)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 7900339.19
EU funding (EUR): 6675031.9
Participants: 26
Project status: CLOSED

Measurement campaigns have shown major discrepancies in buildings energy performance between planned energy demand and real energy consumption, while nowadays most of the newly constructed offices buildings are equipped with BMS systems, integrating a more or less extended measurement layer providing large amounts of data. Their integration in the building management sector offers an improvement capability of 22 % as some studies demonstrate. The HIT2GAP project will develop a new generation of building monitoring and control tools based on advanced data treatment techniques allowing new approaches to assess building energy performance data, getting a better understanding of building’s behaviour and hence a better performance. From a strong research layer on data, HIT2GAP will build on existing measurement and control tools that will be embedded into a new software platform for performance optimization. The solution will be: - Fully modular: able to integrate several types and generations of data treatment modules (different algorithms) and data display solutions, following a plug and play approach - Integrating data mining for knowledge discovery (DMKD) as a core technique for buildings’ behaviour assessment and understanding The HIT2GAP solution will be applied as a novel intelligent layer offering new capability of the existing BMS systems and offering the management stakeholders opportunities for services with a novel added value. Applying the solutions to groups of buildings will also allow to test energy demand vs. local production management modules. This will be tested in various pilot sites across Europe. HIT2GAP work will be realized with a permanent concern about market exploitation of the solutions developed within the project, with specific partnerships about business integration of the tools in the activity of key energy services partners of the consortium.

Keywords: intelligent building,data mining,users,monitoring,modelling,energy savings,facility management
Next Generation Advertising: Social Video Software Connecting Brands and Content Creators (OCTOLY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In a market where young consumers watch YouTube more than TV, brands have no effective way of analysing and improving the impact of video advertising on social media. What’s more, independent content creators on YouTube capture greater audiences than “official” brand channels – yet companies have no easy way of working with these influential creators who talk about their brand. In turn, successful “YouTubers” have no way of turning their talent into a concrete commercial opportunity. Octoly aims to develop a 360° software suite that enables businesses to regain control of their brands on YouTube, analyse the impact of their branding strategy and create synergy with YouTube's independent content creators. An initial version of Octoly’s brand management software for Social Video is already being pilot tested by all of L’Oreal’s European subsidies and the leading US gaming company Blizzard. The aim of the feasibility study is to identify the full technical specifications for the envisaged final product and to conduct a detailed market study on the needs of brands and independent YouTubers. The project meets specific objectives identified by the Commission as part of the flagship Digital Agenda, namely the need for European businesses to successfully capitalise on the potential of internet-based content and the emergence of new types of entrepreneurs through social media As the only European solution of its kind, Octoly aims to rapidly gain market leadership in this market via a unique conceptual and technical approach.

Keywords: social video,brand management
A miniaturized system to secure the cold chain (TEMPIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: TERMINATED

We have developed an affordable and easy-to-adopt way of securing cold chains: Tempix time-temperature smart labels. Our labels guarantee that products are handled at the correct temperature throughout the entire cold chain. If the product is exposed to conditions above the stipulated temperature for an extended period, the bar code will be blocked rendering it unsellable. We provide a complete turnkey solution comprising a 2- in-1 thermal label printer and a cover label applicator. The market has welcomed our innovation. Nowadays, Tempix labels secure LIDL’s fresh fish cold chains in Finland. Furthermore, we are running pilots with other prestigious companies around the world. For all its virtues we are aware of the limitations of our solution. Tempix printers are big and require compressed air to operate. These factors restrict our targeted users to major primary food producers and factories with large single story floor space. For Tempix technology to reach its full potential, it is necessary to develop a desktop-sized version of our system. To scale up, we must scale down. In this Phase 1 study, we will scout for the most suitable technology and manufacturing partner to achieve miniaturisation. Simultaneously, we will develop a strategy for market deployment.

Keywords: cold chain,food waste,last expiry date,temperature control
RustWatch: A European early-warning system for wheat rust diseases (RUSTWATCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Germany,Italy,Sweden,Switzerland,Poland,Slovakia,Sweden,Latvia,Latvia,France,France,France,Czechia,Pakistan,Denmark,Denmark,United Kingdom,United Kingdom,Denmark
Call: Research and approaches for emerging diseases and pests in plants and terrestrial livestock (H2020-SFS-2017-2, 2017)
Start date: 2018-05-01
End date: 2022-09-30
Duration (months): 53.0
Total project cost (EUR): 4999998.75
EU funding (EUR): 4999998.75
Participants: 27
Project status: SIGNED

RustWatch will establish a stakeholder driven early-warning system to improve preparedness and resilience to emerging rust diseases on wheat, which is Europe’s largest agricultural crop. This is urgent because Europe in 2016 experienced the most severe epidemics of wheat stem rust for more than 50 years, and the pre-existing population of wheat yellow rust has been replaced by invasive races of non-European origin. RustWatch will address all areas listed in the call, including exploring the drivers shaping the new European wheat rust populations, assessment of their impact on agricultural productivity in the context of IPM Directive 2009/128/EC, and finally develop research and communication infrastructures taking advantage of stakeholder networks and expertise, and collaboration via existing global networks. RustWatch provides beyond state-of-the-art research within new diagnostic tools, enabling rapid and precise identification of new invasive races, and investigating the impact of virulence, aggressiveness and adaptation to warmer temperatures as drivers of pathogen spread and establishment. The research has potential for a break-through in the area of host resistance phenotyping, e.g., by going beyond the observation of disease and categorize resistance responses at the cellular level. This phenotyping is essential for utilizing the vast amount of genomic sequence information produced by new emerging breeding technologies. The early-warning system for prevention and control of rust diseases will become implemented via case studies in five regions. The case studies will aid in development and validation of the systems in collaboration with a wide array of stakeholder groups, involve agricultural advisers in disease surveillance and sampling for later diagnosis, and collect information about potential barriers in adopting the system. RustWatch engages 12 universities/research institutes, 5 agricultural advisory services, and 8 SMEs/industries.

Keywords: rust pathogen,plant breeding
Solid-liquid thermoelectric systems with uncorrelated properties (UncorrelaTEd)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Sweden,France,France,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 2543322.5
EU funding (EUR): 2543322.5
Participants: 7
Project status: SIGNED

More than 60% of the global power is lost as waste heat. Thermoelectric (TE) materials can convert vast amounts of this waste heat into electricity and significantly contribute to the current energy challenge. Despite large efforts to identify better TE materials, still, the TE technology is limited by low efficiency. One of the two performance improvement routes, thermal conductivity reduction, has already reached its limit, which makes the other route, power factor (PF) improvements, crucial. Current strategies targeting PF enhancement have only reached modest improvements, mainly due to the adverse interdependence of the Seebeck coefficient (S) and the electrical conductivity (σ), which produces a decrease in one of these properties if the other is increased. This is a serious obstacle to achieve the widespread application of the TE technology, since PF=σS^2. UncorrelaTEd will come true the dream of breaking the S-σ correlation by introducing a new paradigm in thermoelectricity that comes from the connection of TEs and electrochemistry, using a properly designed hybrid system, formed by a porous TE solid permeated by a liquid electrolyte. The porous solid provides a low thermal conductivity, whereas the electrolyte tactically interacts with the solid to enlarge the PF. Unprecedented PF improvements (above 35 times) have already been observed by UncorrelaTEd members in this system using a material with modest TE properties. UncorrelaTEd aims at extending these improvements to different materials (bismuth telluride alloys, oxides, and polymers) with state-of-the-art TE properties, potentially leading to an extraordinarily powerful technology able to provide more than 4 times larger PF than state-of-the-art low-mid temperature (<150 ºC) materials and ZTs>3. This will enable the TE technology to be implemented in many areas, such as self-powered sensors, empowering the elimination of batteries, textiles, factories, power plants, and combustion engines.

Keywords: thermoelectrics,electrochemistry,energy harvesting,electrolytes,ionic liquids