Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unique collaborative ecosystem and programme for promoting the transatlantic cooperation in NGI technologies (NGI Sargasso)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: France,Spain,Estonia,United States
Call: NGI International Collaboration - USA and Canada (RIA) (HORIZON-CL4-2022-HUMAN-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 6000000.0
Participants: 5
Project status: SIGNED

The EU, the US and Canada share the values of democracy, human rights, the rule of law, and economic and political freedom, and have overlapping foreign policy and security concerns. Close cooperation and strategic relations with the US and Canada remain a priority for the EU. The Next Generation Internet (NGI) initiative supports this vision of building bridges internationally, especially with the US and Canada. In fact, there have been many initiatives since 2016 focused on enhancing collaboration and cooperation in the development of NGI technologies, services, and standards with the US and/or Canada. The advancement of emerging topics for the EU NGI and corresponding US and Canadian programmes such trust and data sovereignty, digital identity, internet architecture renovation, decentralised technologies and standards, it is of outmost importance to shape the future Internet. In this context, NGI Sargasso’s mission is to catalyse transatlantic collaboration on the development and experimentation of new ideas, implementation of prototypes, and contribution to standards and open-source communities on technology trends with the potential to reshape tomorrow’s NGI technologies and services. The project will run five open calls for proposals, attracting +300 EU + US and/or Canada teams working on emerging topics for the Next Generation Internet, and will support up to 96 projects that will be benefited from both equity-free funding and capacity building services in a 9-month programme. The consortium is led by the European Science Foundation (an EU association with a network of over 40,000 experts across all scientific disciplines and over 83 countries), and counts with the support of MWCB (an ecosystem builder driving the digital advancement of society), SPLORO (whose team has been part of different NGI projects, including the EU-US fellowship programme NGI Explorers), and AUSTRALO (leader of the community building in NGI Explorers and Think NEXUS), as core partners.

Keywords: next generation internet,trust,data sovereignty,digital identity,internet architecture,dlt standards,business support services,business model,incubation,acceleration,investment
Mineralization within macromolecular condensates – the chemical playground of living cells (LivingCrystals)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Organisms form crystalline materials with superior structural and mechanical properties. This arises from the ability of functional macromolecules to create intricate architectures via a multi-step crystallization process. Current approaches to engineer bioinspired minerals focus on interactions between macromolecules and minerals in dilute aqueous environments, rarely considering the emergent properties of macromolecular condensates. However, we and others showed that macromolecular crowding is intimately associated with biomineral formation in vivo. In this project, we will develop a new type of chemistry—dense-phase mineralization—to unlock the pathways mastered by nature. Our hypothesis is that weak polymer-ion interactions within dense phases tune the chemical landscape, controlling the crystallization process and the properties of its products. Remarkably, our preliminary results using the calcium carbonate system show that molar-range polymer concentrations, four orders of magnitude denser than in previous works, result in intricate crystals with life-like properties. We will investigate dense-phase mineralization in both synthetic and living systems, relying on our unique expertise in cryo-electron and X-ray microscopies of hydrated biological samples. In Aim 1, we will grow crystals in a dense polymer phase and use the crowded environment to sculpt architectural motives. In Aim 2, we will investigate the challenging phase separation regime and transform inorganic condensates into transient precursors for mineralization. In Aim 3, we will elucidate how liquid-liquid phase separation evolved by mineralizing organisms to regulate inorganic condensate formation. This project will open an uncharted chemical landscape to form and control bioinspired minerals. The outcome will be a toolbox for process design that allows to optimize material properties - the highest gain we can ask for in bioinspired mineralization.

Keywords: biomineralization,non classical crystallization,phase separation,cryo electron microscopy,calcium carbonate
The impact of chromatin on genome organisation, function and evolution (CHROMOGENEVO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Chromatin contributes to many important processes ensuring the proper functioning of eukaryotic cells. In addition, it shapes linear and spatial genome organisation, and specifies chromosomal regions including centromeres that play a key role for chromosome segregation. Chromatin-associated factors also fold the genome in 3D to enable the transfer of chromosomes during mitosis or to regulate gene expression. Chromatin composition is however not identical among eukaryotes. How differences in chromatin composition contribute to different linear and spatial genome organisations is largely unknown. We aim to address these unknowns in three non-overlapping aims focusing on Lepidoptera and other insects as a model system. First, we will investigate how the disruption of an essential chromatin-based epigenetic loop underlies a drastic case of centromere divergence. To this end, we will perform homology studies on centromere-specifying factors to correlate them with centromere profiles in representative insects that have convergently evolved a holocentric architecture (chromosome-wide centromeres) from monocentric ancestors (centromeres restricted to one chromosomal region). Second, applying a combination of genomics, microscopy and biophysical simulations in the holocentric moth Bombyx mori we will test how the chromosome-wide distribution of centromeres affects the spatial organisation of mitotic chromosomes. Third, using B. mori and exploiting extensive genomic datasets from related Lepidoptera we will investigate how unprecedented features in 3D genome organisation including a new chromatin compartment that we identified affect genome function and organisation over evolutionary time. With our proposal, we will reveal how changes in chromatin lead to reorganisation of essential genomic regions and shape the topology of chromosomes in 3D, and in turn how this spatial dimension influences genome structure across evolution.

Keywords: centromere,genome organisation,chromatin,mitosis,chromatin compartments,genome evolution,smc complexes,insects
Uncovering the role and regulation of 3D DNA-RNA nuclear dynamics in controlling cell fate decisions (DarkCellFader)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

At the onset of mammalian life, the first lineage specification decision is made where embryonic cells opt to become either part of the placenta or the future body. Proper regulation of this choice is crucial for subsequent development. However, we don’t know how the transcription program and 3D genome architecture arise, interconnect, and are controlled to determine the fate of each cell in a developing embryo. Recent studies, including my work, suggest that in addition to canonical mRNA-coding genes, RNAs from the “dark” parts of the genome (e.g., transposons, repeats, long-non-coding RNAs) play a significant role during these events, yet how specific classes of RNA regulate gene expression and nuclear architecture post fertilization remains elusive. The main aim of my proposal is to understand the interrelationship between 3D genome organization and the transcriptome across early development and to identify novel factors that lead to the first cell-fate decision and concomitant decrease in cell potency. Recent technical advances, which I co-developed, enabled simultaneous measurement of 3D genome organization and the transcriptome, and facilitated large-scale functional screens in early mammalian embryos. Thus, I now propose to generate spatiotemporal maps of 3D DNA and RNA organization from early mouse embryos at single-cell resolution (Obj.1) to build a complete picture of the relationships between nuclear architecture and emerging cell-type specific transcriptome that drive early cell fate choices. I will combine these data with large-scale in vivo perturbations targeting protein coding genes (Obj.2) and dark genome RNAs (Obj.3) to identify key inducers/regulators of lineage specification and to determine molecular mechanisms governing cell-state transitions. The proposed research will help us to control, correct, and eventually employ early stages of embryonic development and their high cell potency in vitro in reproductive medicine and stem cell research.

Keywords: early embryonic development,dark genome rnas,3d genome organization,gene expression,single cell omics,cell potency
Disorder in ultrafast phase transitions (DISRUPT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

DISRUPT, which stands for "DISorder in Ultrafast Phase Transitions," represents a theoretical physics initiative with the primary aim of harnessing both static and time-dependent disorder to gain full control over ultrafast phase transitions occurring in quantum materials. A key aspiration within the realm of nonequilibrium physics is to attain the ability to manipulate the properties of quantum materials over time, offering numerous potential applications in high-impact technologies such as ultrafast electronics, probabilistic computing, and quantum computing. However, in experiments where a pump-probe approach is employed, disorder is often viewed as an unwelcome factor that threatens to undermine the vision of achieving complete control over the dynamics of quantum many-body systems through the use of light. Our objective is to challenge this conventional perspective and demonstrate that disorder serves two fundamental purposes: Firstly, it enables us to place the system in nonthermal states that would be otherwise inaccessible under equilibrium conditions (as seen in ultrafast inhomogeneous disordering). Secondly, it allows us to theoretically devise robust mechanisms for preventing the thermalization of quantum systems, with direct implications for quantum memory technology. This dual objective lies at the core of our proposal. To accomplish these objectives, we plan to implement, for the first time according to our knowledge, an out-of-equilibrium extension of real-space Dynamical Mean Field Theory. This will enable us to investigate both the (absence of) thermalization in correlated electron systems experiencing static quenched disorder (Many-Body Localization) and the ultrafast inhomogeneous disordered transition in vanadium dioxide involving annealed time-dependent disorder.

Keywords: inhomogeneous disordering noise and fluctuations electron phonon interaction electron electron interaction ultrafast phase transitions many body localization statistical dmft condensed matter
Figuring the Invisible: Conventions and Tactics in Animation for Science Outreach (FICTA SciO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 207609.6
EU funding (EUR): 207609.6
Participants: 3
Project status: CLOSED

The research will identify and raise awareness about the audiovisual conventions and communication tactics of animation in multimedia science outreach, in respect to the representation of invisible objects (too big, too small, too far away in space and time). The research is in the field of animated documentary, a major point in the Animation Studies agenda (Honess Roe, 2013). It is also based on the epistemology of scientific communication; as Daston and Galison argued (2007), «truth-to-nature» objectivity is being superseded by visuals balancing art and science. Merleau-Ponty (1964) had previously called for an equilibrium between objectivity and subjectivity in science outreach, due to the new “invisible” frontiers of knowledge. The action will start with 12 months at the Lucerne University of Applied Sciences and Arts, whose excellence in visual research and its interdisciplinary environment will support the Researcher in: 1) building a list of animations in multimedia science outreach from 1980; 2) critically engaging the conventions and tactics from the point of view of animation theory, 3) of animators and 4) of scientists (in dialogue with the resident experts on data visualization). The next 12 months will be hosted by the Department of Cultural Heritage of the University of Padova, Italy. With the collaboration of the Department of Information Engineering and the CICAP (the Italian committee for scientific skepticism), the results from the outgoing phase will be used to: a) create an open access database of multimedia science outreach about the “invisible”; b) set up educational actions; c) create a permanent committee to promote good practices in animation for science. The Researcher will take advantage of his expertise in animation history and theory, his contacts with the industry and with animation schools, and his teaching experience. The research will consolidate his career and make him a mediator between academia, scientists, and filmmakers.

Keywords: animation science outreach
High Performance, Safe, Secure, Open-Source Leveraged RISC-V Domain-Specific Ecosystems (ISOLDE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Germany,Romania,Austria,Spain,France,Italy,Sweden,Czechia,Switzerland
Call: Design of Customisable and Domain Specific Open-source RISC-V Processors (IA) (HORIZON-KDT-JU-2022-1-IA, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 39410109.71
EU funding (EUR): 11582733.37
Participants: 41
Project status: SIGNED

The ISOLDE project aims to significantly support the digital transformation of all economic and societal sectors, to speed up the transition towards a green, climate neutral and digital Europe, to strengthen the design capacity and to achieving digital autonomy EU wide. By the end of our project, we will have high performance RISC-V processing systems and platforms at least at TRL 7 for the vast majority of building blocks, demonstrated for key European application domains such as automotive, space and IoT with the expectation that two years after completion ISOLDE’s high performance components will be used in industrial quality products. To achieve such an ambitious goal, an industrial-grade open-source support for development, verification, and maintenance will be provided. The customizable IPs will be hosted on physically located European servers to address the European digital sovereignty requirement that the ISOLDE project will support. This way, ISOLDE will have delivered a major contribution to the unification and focus of the full-fledged – industry-supported – eco-system for RISC-V open-source architecture, especially in the area of embedded high-performance computing, and thus to the creation of a breakthrough design capacity across the EU microelectronics industry.

Keywords: risc v,open source,multicore,safety critical system,security critical system,high performance,superscalar
Hydrogen Production in Pressurized 3D-Printed Solid Oxide Electrolysis Stacks (HyP3D)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,Denmark,Italy,France
Call: Development and validation of pressurised high temperature steam electrolysis stacks (Solid Oxide Electrolysis) (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2543398.75
EU funding (EUR): 2543398.75
Participants: 8
Project status: SIGNED

Reliable and stable operation under pressure is one of the major challenges of currently existing Solid Oxide Electrolysis (SOEL) technologies for its ultimate application in relevant sectors such as energy storage and transport. The main goal of HyP3D is to overcome this barrier by delivering disruptive ultra-compact and lightweight high-pressure SOEL stacks, able to convert electricity into compressed hydrogen, for gas grid injection (P2G) and on-site generation in Hydrogen Refueling Stations (HRS). HyP3D stacks are based on innovative 3D-printed SOEL cells with unprecedented mechanical properties, embedded functionality and self-tightening capabilities implemented by design. These unique advantages will allow operation at pressures above five bars without the need of unpractical, energy inefficient and costly pressure vessels, which is the only actual solution for pressurization despite their low reliability. Breakthrough HyP3D geometries will multiply by more than three times the volume and mass specific power density of conventional technologies (reaching 3.40kW/L and 1.10 kW/kg, respectively), resulting in pressurized SOEC stacks with a remarkably reduced footprint (one third of state-of-the-art stacks) and ultra-low use of raw materials (76% reduction). Moreover, the elimination of any vessel will increase the system efficiency, reduce the final cost and substantially simplify the scaling-up towards required MW-size systems. The project is product-driven and involves industrial partners with proved experience in mass manufacturing of ceramics by 3D printing, glass-to-metal sealing and assembly of electrolysers, which will ensure, together with the presence of P2G and HRS stakeholders, competently covering the entire value-chain. HyP3D technology will be fabricated in a pilot line, which will ensure reaching stack level and validation at laboratory scale by 2025 (TRL=4).

Keywords: soec,solid oxide electrolysis,3d printing,hpc,ceramic processing