Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting quantitative traits and their underlying genetic interactions via systematic genome editing (SystGeneEdit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 2499995.0
EU funding (EUR): 2499995.0
Participants: 1
Project status: CLOSED

Despite the ubiquity of genome sequence data, unravelling the contributions of genetic variation to phenotypic diversity remains one of the greatest challenges in genomics. This is partly due to our very limited knowledge of how multiple variations combine to create phenotypes. There is a clear need for a systematic, perturbation-based approach to study the phenotypic consequences of genetic variants in different genomic and environmental contexts. Previous efforts have primarily used loss-of-function or overexpression approaches, but it is known that subtle, naturally occurring variants have the most relevance for complex, quantitative traits. Our proposal aims to dissect these effects by systematically engineering and functionally profiling naturally occurring single-nucleotide variants (SNVs) and small insertion/deletion polymorphisms (indels) in the S. cerevisiae species in three diverse genetic backgrounds. To generate such an unprecedented collection, we will apply a high-throughput CRISPR approach that allows rapid isolation of sequence-verified strains. DNA barcodes integrated into the genome of each strain will enable pooled, competitive growth, which will reveal how variants modulate fitness as a function of environment and genetic background. We will test our collection for pairwise and higher order interactions, assay their impact on cellular processes and dissect pleiotropic roles of highly connected genes. Our work will circumvent the key limitations in current high-throughput genome editing screens and enable the largest interrogation of the functional impact of genetic variation in different environmental and genetic contexts to date. The combined insights and tools generated by our work will aid in developing predictive models of the effects of genetic variation within specific environmental and biological contexts, providing guiding principles for understanding the consequences of human genetic variation.

Keywords: crispr,genome editing,complex traits,genetic variation,genetic interactions
BENE Innovation Internationalisation services 2019 (BENEI2 2019)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 44340.0
EU funding (EUR): 35472.0
Participants: 2
Project status: CLOSED

The project aims at offering specific innovation services to 2 different groups of SMEs based in the Brussels Capital Region: - the SME-I / FTI / FET Open beneficiaries on the one side, and - the SMEs having a high potential for growth and internationalisation by the enhancement of their innovation management capacity on the other side. These services will be an integral part of the Enterprise Europe Brussels services and will be provided in the frame of a sounded client's journey approach, in lin with the company's life cycle. Although for the SME-I / FTI / FET Open beneficiaries the proposer depends on the number of successful SME granted and notified by EASME, a funnel approach will be adopted for both groups of SMEs in order to have an upstream estimation and selection of the SME potential existing in the region. This funnel and selective approach will also take into consideration the permeable frontiers which divide one SME group from the other, in the light of the innovation needs and capacities existing at a given time of the SME lifecycle. The service provision for Group 2 will be ensured via a structure process, relying on a contest approach, SME pre-selection, set-up according to a predefined methodology, which relies on ad-hoc tools (and based on 9 criteria) and methodologies, designed with the aim to select only those SMEs with capacity, clear intent and ambition to benefit from the innovation management assessment. In function of the score obtained in the different criteria, the SME will be selected (or not) to benefit from the innovation management capacity assessment held with one of two retained tools, both complaint to EU standard CEN/TS 16555-1 “Innovation management system”. The BENEI2 2019 proposal addresses the obstacles which hinder SME from being more competitive, from growing and creating jobs, thus having a real impact in the regional economy.

Keywords: innovation,internationalisation,innovation management capacity,impact,competitiveness,sme i,fet open beneficiaries
Tundra biogenic volatile emissions in the 21st century (TUVOLU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 2347668.0
EU funding (EUR): 2347668.0
Participants: 1
Project status: SIGNED

Biogenic volatile organic compounds (BVOCs) influence atmospheric oxidation causing climate feedback thought to be especially significant in remote areas with low anthropogenic emissions, such as the Arctic. Still, we do not understand the dynamics and impact of climatic and biotic BVOC emission drivers in arctic and alpine tundra, which are highly temperature-sensitive BVOC sources. TUVOLU will redefine tundra BVOC emission estimates to account for rapid and dramatic climate warming accompanied by effects of vegetation change, permafrost thaw, insect outbreaks and herbivory using multidisciplinary, established and novel methodology. We will quantify the relationships between leaf and canopy temperatures and BVOC emissions to improve BVOC emission model predictions of emission rates in low-statured tundra vegetation, which efficiently heats up. We will experimentally determine the contribution of induced BVOC emissions from insect herbivory in the warming Arctic by field manipulation experiments addressing basal herbivory and insect outbreaks and by stable isotope labelling to identify sources of the induced emission. Complementary laboratory assessment will determine if permafrost thaw leads to significant BVOC emissions from thawing processes and newly available soil processes, or if released BVOCs are largely taken up by soil microbes. We will also use a global network of existing climate warming experiments in alpine tundra to assess how the BVOC emissions from tundra vegetation world-wide respond to climate change. Measurement data will help develop and parameterize BVOC emission models to produce holistic enhanced predictions for global tundra emissions. Finally, modelling will be used to estimate emission impact on tropospheric ozone concentrations and secondary organic aerosol levels, producing the first assessment of arctic BVOC-mediated feedback on regional air quality and climate.

Keywords: arctic tundra,alpine tundra,ecosystem modelling,global predictions,biogenic volatile organic compounds,insect herbivory,permafrost thaw,temperature,climate change
Surveillance mechanisms regulating nuclear envelope architecture and homeostasis (ProteoNE_dynamics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1999610.0
EU funding (EUR): 1999610.0
Participants: 1
Project status: SIGNED

The nuclear envelope (NE) is a major hub of eukaryotic cellular organization, influencing a myriad of processes, from gene regulation and repair to cell motility and fate. This central role of the NE depends on its elaborate structure, particularly on the organization of its inner nuclear membrane (INM). This peculiar membrane is continuous with the rest of the endoplasmic reticulum (ER) but faces the nucleoplasm and contains a distinctive set of proteins, which confer a unique identity to the INM. Importantly, mutations in several INM proteins result in a wide range of diseases, such as muscular dystrophies and premature aging syndromes, highlighting the key roles of the INM proteome in cell homeostasis. However, the mechanisms establishing and maintaining the INM proteome identity and integrity have remained mysterious. My lab recently identified a quality control system that, by targeting aberrant proteins for degradation, regulates INM identity and homeostasis. This proposal describes a framework to expand our findings and to provide a comprehensive and integrated understanding of the INM proteome. By combining my expertise in membrane protein analysis with newly developed proximity biotinylation and proteomics approaches, we will for the first time probe the complex INM environment of living mammalian cells. A systematic examination of the INM proteome, its turnover rates and changes in response to different physiological conditions will reveal functions of INM proteins and their regulatory pathways. Moreover, it will characterize INM surveillance mechanisms and evaluate their contributions to NE proteostasis. In sum, this proposal will provide a panoramic yet detailed view of the mechanisms underlying INM functions, identity and homeostasis, both in interphase and during NE reformation in mitosis. Given the clinical relevance of many INM proteins, our studies may illuminate current understanding of diseases such as laminopathies and cancer.

Keywords: protein quality control,endoplasmic reticulum,nuclear envelope,organelle homeostasis,ubiquitin dependent degradation
INTEGRATED NOVEL STRATEGIES FOR REDUCING THE USE AND IMPACT OF PESTICIDES, TOWARDS SUSTAINABLE MEDITERRANEAN VINEYARDS AND OLIVE GROVES (NOVATERRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Italy,Spain,Italy,Spain,Spain,Italy,Belgium,Greece,Greece,France,France,France,Portugal,Portugal
Call: Integrated health approaches and alternatives to pesticide use (H2020-SFS-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 5507110.2
EU funding (EUR): 4884346.35
Participants: 23
Project status: SIGNED

The DIRECTIVE 2009/128/EC ON THE SUSTAINABLE USE OF PESTICIDES gives directions for attaining the sustainable use of pesticides in the EU. The objective is to minimize risks and impacts for the environment and human health by promoting alternative strategies. Integrated Pest Management (IPM) is one of the cornerstones of the Directive. NOVATERRA aims to reduce the use and negative impacts of CONTENTIOUS PLANT PROTECTION PRODUCTS (PPP) for integrated pest, disease and weed management in the two main Mediterranean crops in Europe: grapevines and olives. NOVATERRA will develop a pool of novel, integrated and sustainable strategies, technically and economically viable, resulting from three different approaches: a) To develop novel combinations of ALTERNATIVE, non-synthetic PRODUCTS and biological control techniques for plant protection, b) To optimize the application and dosage of PPP through SMART FARMING technologies and c) To mitigate the appearance of pest and diseases through the use of new SOIL MANAGEMENT strategies. Those approaches will be evaluated and validated in a combination of integrated solutions for updating and improving IPM strategies. Indicators for measuring the impact of crop management and protection on human health, air, water, soil, biodiversity, energy will be implemented. Further analyses will be done in terms of economic cost-benefit for farmers to adopt the different techniques and farmers and consumers’ willingness to pay. The consortium composition will guarantee a multi-actor approach with contributions coming from research institutions, growers, technological SMEs, auxiliary industry and relevant associations. Finally, the Exploitation Plan together with the Communication and Dissemination Plan will ensure the outreach of results among the stakeholders in the European farming sector. NOVATERRA outputs will also be key for further discussion with policymakers in terms of EU plant health policies and risk assessment around PPPs usage.

Keywords: contentious pesticides,grapevine,olive,pests,diseases,weeds,smart farming,soil management,biopesticides
Developing optoelectronics in two-dimensional semiconductors (2Exciting)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland,Italy,Spain,Germany,Germany,Switzerland,Poland,France,Czechia,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3921765.48
EU funding (EUR): 3921765.48
Participants: 10
Project status: SIGNED

Atomically thin, two-dimensional semiconductors (2DS) show exceptionally strong light-matter interaction and opened the door to new ways of controlling electrical and optical properties through the valley degree of freedom, strain, or by creating artificial stacks of 2D materials. Optoelectronics has a clear roadmap towards not only broader band, faster and higher sensitivity or brighter devices, but also devices with new functionalities. The fast growth of industrial applications of 2DS in the imminent future, where Europe is in an excellent starting position, risks being throttled by a lack of highly qualified researchers and developers with specific experience in the field. The 2EXCITING network blends together eight academic groups that are amongst the key players in the 2DS field and eight companies with very diverse profiles, to train 15 Early Stage Researchers in an unmatched combination of scientific and complementary skills. Together, they will study the fundamental physics of the light-matter interaction in 2DSs, develop innovative optoelectronic devices such as excitonic switches, strain-actuated optical modulators, or valleytronic switches, and develop strategies to artificially tailor the optoelectronic properties of 2DS through electrostatic or chemical doping, strain engineering or the twisting angle of stacked layers. The network training programme, which comprises three winter schools and three satellite events to the “Flatlands beyond Graphene” conference series, provides scientific and industrial training to all researchers of the ETN, with active participation of trainers from the involved non-academic partners, both on specific technology issues and on complementary skills such as technology transfer, entrepreneurship, and public outreach. All ESRs will spend intersectoral and international secondments (be seconded from academia to industry or vice versa), most of them for six months duration.

Keywords: two dimensional semiconductors,transition metal dichalcogenides,photophysics
Pregnancy and the Human Brain: A Window of Neuroplasticity (PREGBRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Pregnancy represents one of the most extreme endocrine events of life, involving unequaled hormone surges that orchestrate widespread maternal adaptations. Animal studies have demonstrated reproduction-related neural and behavioral changes that are evident across the lifespan. However, remarkably little is known on the effects of this monumental transition on the human brain. I have previously shown—for the first time—that pregnancy leads to long-lasting changes in human brain structure, revealing the existence of a dramatic pregnancy-related neuroplasticity in humans. Building on these results and new pilot data, I propose a cutting-edge research project that aims to A) comprehensively map the changes manifesting in a woman’s brain by tracking core aspects of brain anatomy and function across pregnancy and the postpartum period, B) pinpoint key factors driving pregnancy-related neuroplasticity by means of an extensive profile of endocrine and lifestyle changes, and C) reveal the neural substrates for potential adaptive and maladaptive processes, focusing on specific functional domains highlighted by promising pilot results. I postulate that pregnancy-related changes in a woman’s brain not only underlie well-known adverse peripartum processes such as the development of mental health disorders and memory issues, but also comprise adaptive processes conferring long-lasting changes in specific domains of functioning that play a key role in—but are not restricted to—maternal caregiving. I will investigate this novel topic by means of an innovative prospective cohort study tracking women from before conception across pregnancy and into the postpartum period, which combines cutting-edge neuroimaging approaches with various psychopedagogic and biomedical measures. The proposed project has the potential to lay a firm foundation for this emerging field of human neuroscience and generate groundbreaking insights into a woman’s remarkable neurobiological journey to motherhood.

Keywords: pregnancy,brain,motherhood
Iwasawa theory of elliptic curves and the Birch–Swinnerton-Dyer conjecture (IwCMEBSD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

The Birch–Swinnerton-Dyer conjecture is a Millenium Prize Problem and is unquestionably one of the most important open problems in mathematics. It concerns elliptic curves E, which are indispensable in today’s society as they are extensively used in the form of cryptography. Iwasawa theory proved to be an extremely powerful tool in modern number theory, and it serves as a bridge between the two mysterious mathematical objects appearing in the conjecture (the Tate–Shafarevich group and the complex L-series) which are completely different in nature, by allowing us to study it at one prime number at a time. In this proposal, E will have complex multiplication, since their L-series are known to be defined at the critical point. The classical theory only deals with odd primes p. Even though p = 2 is the most interesting prime for the conjecture, it is always omitted because of serious technical difficulties, preventing classical methods from obtaining the full conjecture for any curve. Furthermore, E is always defined over the rational numbers or the field K of complex multiplication. A main reason for this is that the Iwasawa modules are not semisimple at p = 2 and p dividing the class number h of K. I will explore and apply the full force of Iwasawa theory and aim to include the eschewed prime. This is made possible by my recent results on an Iwasawa main conjecture at p = 2 and the vanishing of Iwasawa μ-invariant. The first research project deals with a family of elliptic curves which are defined over extensions of K. For these curves, I propose to show the p-part of the Birch–Swinnerton-Dyer conjecture for ordinary primes p, which include p = 2 and p dividing h. The second project explores noncommutative Iwasawa main conjecture at p = 2 by combining the early works of Colmez–Schneps and the recent work of Kings–Sprang. Finally in the third project, I will use an elliptic curve from the second project to propose and study an analogue of Weber’s class number problem.

Keywords: birch swinnerton dyer conjecture,iwasawa theory,elliptic curves,complex multiplication,class numbers