Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Theoretical developments for precision spectroscopy of polyatomic and polyelectronic molecules (POLYQUANT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Hungary
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1424175.0
EU funding (EUR): 1424175.0
Participants: 1
Project status: SIGNED

I propose research for an increasingly accurate quantum mechanical computation of small molecular systems including non-adiabatic, relativistic, and radiative effects. The computed rovibronic energy intervals will be directly comparable with high-resolution and precision spectroscopy measurements. The accuracy goal for theory (and experiment) is more than six-orders of magnitude tighter than the usual chemical accuracy defined to be on the order of 1 kcal/mol. The rovibronic eigenstates obtained from effective non-adiabatic, relativistic-radiative Hamiltonians to be developed will provide the most fundamental and most detailed quantum dynamical fingerprint of the molecular system, and as a complete database they are necessary for the simulation of a variety of molecular phenomena including ultrafast laser-molecule interactions.

Keywords: theoretical molecular quantum dynamics of small,gas phase molecules,non adiabatic,relativistic and radiative effects in the molecular spectrum
Bridging the gap between public opinion and European leadership: Engaging a dialogue on the future path of Europe. (EUENGAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Romania,Belgium,Netherlands,United Kingdom
Call: Political challenges for Europe (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 2496633.0
EU funding (EUR): 2496633.0
Participants: 7
Project status: CLOSED

The goal of the EUENGAGE Project is twofold: first, to inquire into the current tensions between supranational EU governance and popular mobilisation at the national level, critically questioning EU-driven policies and EU legitimacy; and second, to propose remedial actions based on sound empirical research on the relationship between public opinion, national and supranational political elites. The medium to long-term evolutionary trend of the EU system of supranational governance has already in the past given rise to a manifestation of problems. It has become clear that the pace of integration proposed from the top, and some side-effects of integration—austerity, transnational redistribution, economic insecurity, immigration—are difficult to accept for large parts of Europe’s citizens. This misalignment is obviously a crucial issue for any system of governance that aims - as the European Union has repeatedly affirmed - to be inspired by democratic principles. The EUENGAGE project takes seriously the present state of affairs and identifies in the conflicting messages emanating from the functioning of political representation a critical and urgent problem for the future of the EU. The EUENGAGE proposes to set up an interactive, dynamic, multilevel and replicable quasi-experimental research design. Using a variety of instruments and techniques, this design will allow us not only to study the process of representation in vivo, but also to test experimentally how innovative and efficient interactions between citizens and politicians can increase citizens’ awareness of the common problems of the Union, and the ability of the European leadership to respond innovatively to the discontent of public opinion.

Keywords: repesentation,trust,elite,mass,public opinion,parties,deliberation,manifestoes
A mimetic implant for low perturbation, stable stimulation and recording of neural units inside the brain. (BRAIN MICRO SNOOPER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1499850.0
EU funding (EUR): 1499850.0
Participants: 1
Project status: CLOSED

Developing brain implants is crucial to better decipher the neuronal information and intervene in a very thin way on neural networks using microstimulations. This project aims to address two major challenges: to achieve the realization of a highly mechanically stable implant, allowing long term connection between neurons and microelectrodes and to provide neural implants with a high temporal and spatial resolution. To do so, the present project will develop implants with structural and mechanical properties that resemble those of the natural brain environment. According to the literature, using electrodes and electric leads with a size of a few microns allows for a better neural tissue reconstruction around the implant. Also, the mechanical mismatch between the usually stiff implant material and the soft brain tissue affects the adhesion between tissue cells and electrodes. With the objective to implant a highly flexible free-floating microelectrode array in the brain tissue, we will develop a new method using micro-nanotechnology steps as well as a combination of polymers. Moreover, the literature and preliminary studies indicate that some surface chemistries and nanotopographies can promote neurite outgrowth while limiting glial cell proliferation. Implants will be nanostructured so as to help the neural tissue growth and to be provided with a highly adhesive property, which will ensure its stable contact with the brain neural tissue over time. Implants with different microelectrode configurations and number will be tested in vitro and in vivo for their biocompatibility and their ability to record and stimulate neurons with high stability. This project will produce high-performance generic implants that can be used for various fundamental studies and applications, including neural prostheses and brain machine interfaces.

Keywords: implants,brain,microelectrodes,flexible,micro and nanotechnologies,nanomaterials,biomaterials,biocompatibility,neurosciences
Homelessness as unfairness (HOME_EU)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Italy,Belgium,Poland,Sweden,France,Netherlands,Portugal
Call: An empirically informed European theory of justice and fairness (H2020-SC6-REV-INEQUAL-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 2111992.5
EU funding (EUR): 2111992.5
Participants: 13
Project status: CLOSED

Empirically informing a European theory of justice is a complex and challenging endeavour, however the emergence of current social crisis, and the resulting inequalities and unfairness, bring about the need to revise the premises that facilitate translation of the theory into concrete guidance to effective social policies and coherent programs and practices. To respond to this challenge, a trans-disciplinary Consortium has been organized to provide a comprehensive series of empirical data, in different ecological levels, in order to understand differences in perceptions of inequality. Through a case study on an extreme expression of inequality and unfairness - LONG-TERM HOMELESSNESS – organized in a multi-method and convergent design, HOME_EU is focused on understanding: a) How much inequality do EU Citizens accept regarding Homelessness; b) How the people with a lived-experience of Homelessness (both present and past) perceive the opportunities, choices and capability gains with the services and the existing social policies; c) What strategies consider the service providers to be more effective in reversing Homelessness; d) How social policies and policy key stakeholders contribute to effectively reverse Homelessness; and e) Develop a generalizable indicator (correlating the different ecological levels of analysis) based on the data gathered by each partner country on the key elements of policy and program efficacy. We believe that with this journey into an extreme situation, we are able to generate translational knowledge about the ecology of long-term Homelessness and contribute towards the advancement of an empirically based EU theory & practice of justice as fairness.

Keywords: unfairness,social innovation,long term homelessness
Focus alternatives in the human mind: Retrieval, representation, and recall (FAHMRRR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1154438.75
EU funding (EUR): 1154438.75
Participants: 1
Project status: CLOSED

The sentences: “I have written a proposal for the ERC” and “It is for the ERC that I have written a proposal” mean the same, but they have a different focus structure. A focused element like “It is for the ERC” indicates that alternatives are relevant for the interpretation of the utterance. Hence, the sentence expresses, in addition to its literal content, that the proposal is not for the NSF or the German Research Foundation. The alternative set is a theoretical construct from formal semantics, but a number of researchers, myself included, have shown that it is also cognitively real. I propose to further investigate representation, retrieval and recall of an alternative set. First, I will ask the novel question if the decision to focus a phrase activates alternatives in the speaker’s mind. I will explore this with behavioural measures and event-related brain potentials (ERPs). This question brings together two areas of speech production which are rarely considered side by side: conceptualisation and lexical access. Second, I will examine the neural representation of focus alternatives with neuroimaging. While there is convincing evidence for the cognitive reality of focus alternatives, we do not know how this is reflected in the brain. Finally, I will explore individual differences in processing focus information, using large-scale regression analyses. The aim is to understand which abilities enable a human language user to optimally use the focus information provided by the linguistic input. The project’s innovative potential lies both in its questions and in the combination of methods: neuroimaging, ERPs, a range of behavioral measures, and individual differences approaches, which, in combination, will critically advance our understanding of the cognitive and neural basis of processing information structural cues. The findings will be of interest not only to linguists and cognitive scientists, but also to language teachers and people who use language as a tool.

Keywords: linguistic pragmatics,information structure,focus,focus alternatives,language production,language comprehension,individual differences,brain imaging
Diagnosing Pathogen Bacteria Earlier and More Accurately with Biomode’s Probe4@ Rapid Diagnostic Kits (Biomode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-07-01
End date: 2018-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Over 23 million people in the Europe get ill from unsafe food every year, resulting in 5,000 deaths. The majority of foodborne diseases are diarrheal diseases including an estimated 5 million cases of campylobacteriosis annually. We have developed the Biomode Probe4@ solutions based on PNA-FISH technology. The Probe4@ products are cost-efficient, rapid and accurate molecular diagnostic tests based on Peptide Nucleic Acid Fluorescence in situ Hybridization (PNA-FISH) technology for the identification of pathogens in food safety, environmental and clinical applications. Biomode is an innovative company where the core activities are focused on R&D and the commercialization of rapid diagnostic kits based on Peptide Nucleic Acid FISH technology for microbial detection in food and clinical samples. The company focus is to develop and certify its products by internationally recognized organizations such as AOAC. Currently our products Probe4Cronobacter®, Probe4Monocytogenes® and Probe4Salmonella® have already obtained the certification mark by AOAC. In the healthcare market, our product Probe4Pylori® has recently obtained the CE mark. The EFSA has estimated that the overall economic burden of human salmonellosis could be as high as €3 billion a year. By preventing Salmonella to even to get into the retail system, early routine tests are necessary. But those will only be integrated if they are cost effective and easy to use such as the Biomode kits. Our objective is to leverage the diagnostic possibilities of PNA-FISH for all its applications in food safety, clinical and environmental fields, thereby expanding the current possibilities of molecular analysis. We are convinced that the fast, accurate, low-cost and user-friendly diagnostic of certain pathogens through Biomode’s Probe4@ will help decision makers act quickly, thereby saving lives, pain, mistakes and even preventing epidemics.

Keywords: diagnostic tool,molecular diagnostic testing,pna fish,microfluidic platforms,food safety
Sensing Neuro-immune Activation in the Lung microenvironment (SIGNAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The immune system is indispensable for our defense against infections, and plays an essential role in homeostasis, where compartmentalization and specialization are key aspects of every immune cell. Microenvironmental cues (e.g. stromal cell-derived signals) are integrated by the cell networks forming the immune system to maintain immune tolerance or promote immunity against an antigen. Recent findings suggest that neurons also contribute to curb the immune response; they produce neuropeptides that act directly on immune cells such as dendritic cells and neutrophils. However, our understanding of neuroimmune interactions is superficial: we ignore whether specialized cell subsets are responsible for integrating neural cues, we lack precision when studying these connections, and it is unknown whether neuroimmune exchanges are relevant in different tissues and immune reactions, as with the case of lung immune responses related to allergy and chronic obstructive disorders. Asthma has been shown to present a neurological component not yet entirely linked to the immune system. To gain insight into neuroimmune modulation, SIGNAL aims to elucidate the presence and function of neuro-sentinel innate lymphoid cells (nsILC) in the lung: ILC dedicated to detect and translate neuro-derived signals. ILC are tissue resident immune cells which are pivotal coordinators of immune homeostasis, bridging the innate and the adaptive immune system. Using a multidisciplinary approach by combining the selectiveness of optogenetics and chemogenetics with the unbiased power of detection of single cell genomics, and the comprehensiveness of mouse in vivo models, I have setup myself to discover and define nsILC in the context of type-2 responses in the lung. My work will develop our understanding of neuroimmune interactions, and their influence in allergy and asthma, potentially discovering pathways which will provide the context for new approaches in treating this type of disorders.

Keywords: allergy,optogenetics,neuroimmunology
Tracing the global fertility chain- A new political economy of outsourced reproduction (globalfertilitychain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In a new kind of post-Fordist niche, called the reproductive bio-economy, organised around the “flow” of reproductive substances and organs, such as egg cells, embryos and wombs, women are increasingly commercialising their bodies by working as oocyte vendors, surrogate mothers or tissue providers. There is fundamental disagreement among scholars and policy makers on how the reproductive bio-economy should be organised. Market critics propose a gift economy based on altruistic donations and informed consent, while market proponents encourage the commercialisation of reproductive tissues and the remuneration of tissue providers. This research addresses and moves beyond the conflicting terms (gift v. commodity, reproduction v. production, labour v. donation) in which the debate has been framed. It empirically investigates how (bio-)value is created and governed in one particular strand of the “actually existing” reproductive bio-economy, i.e. the global fertility industry, by exploring the intricate ways in which reproductive tissues and labour move in and out of a commodity state as they move through different regimes of governance. By ethnographically mapping the shifting regimes of labour and property in one specific fertility chain that is becoming increasingly popular, i.e. between Israel/Palestine, South Africa (oocyte vending) and Nepal (surrogacy), the volatile boundaries between gift and commodity, value and waste, labour and donation, property and entitlement will be unpacked. This will be done in an attempt to discern “hidden strategies of resistance” of female reproductive workers in the Global South, and propose alternative and more emancipatory ways of configuring the governance of the reproductive bio-economy.

Keywords: globalisation,assisted reproduction,labour,property,value,egg vending,surrogacy,israel,palestine,south africa,nepal,bio economy
Combining hyperspectral luminescence imaging and mineralogical identification to date mixed-component samples from volcanic eruptions (HYPERLIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Volcanic hazards directly affect more than 10% of the world’s population, and have caused globally significant economic losses as recently as 2010. Accurate eruption frequencies are fundamental to risk management, and well-dated volcanic events can temporally link archaeological sites and palaeoclimatic records across hundreds of kilometres. Yet there are significant, known gaps in records of prehistoric volcanic cycles, and accurate luminescence ages for volcanic features would be of great value in future studies. However, volcanic products are mineralogically complex with some crystals producing inaccurate ages. We propose exploring and developing an innovative luminescence technique (‘spatially resolved luminescence’, ‘SRL’) to date volcanic events. SRL uses an ultra-sensitive camera to image luminescence, so that signals can be easily compared with accompanying experimental data (e.g. mineral type or signal stability measurements). This project utilizes luminescence imaging at multiple wavelengths (‘hyperspectral’) and mineralogical analyses to accurately date volcanic ejecta with mixed mineralogy. It builds on the expertise of the supervisor and experienced researcher (‘ER’) in luminescence dating and imaging as well as statistical data analysis, and enhances the ER’s skill set via training in volcanology, the development of analytical software, and the German language and culture. The ER will draw together an international network of leading scientists in industry (Freiberg Instruments) and academia (Universities of Freiburg, Bern, Oxford), allowing her to substantially enhance her leadership skills. As a subsidiary outcome, this project will also increase the European capacity in multiple connected fields, including composite strain analysis (aerospace) and detection of irradiated foods (food standards authorities).

Keywords: luminescence dating,scientific imaging,laser ablation icp ms,risk management