Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ADVANCED QUALITY RENEWABLE ENERGY-POWERED SOLUTIONS FOR WATER DESALINATION IN AGRICULTURE AND WASTEWATER RECYCLING (AQUASOL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Spain,United Kingdom,France,Netherlands,Greece,Denmark
Call: Overcoming barriers and delivering innovative solutions to enable the green transition (HORIZON-CL6-2024-CLIMATE-02, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 3622087.5
EU funding (EUR): 3622087.5
Participants: 7
Project status: SIGNED

The amount of freshwater available has drastically decreased due to rapid population growth, industrialization, and recurring dry extremes. Merely 3% of freshwater makes up all of Earth's water resources, with saline water making up the other 97%. One-fifth of the world's population, according to the World Health Organization, resides in nations where freshwater is scarce. For this reason, desalination of seawateror brackish water is one of the essential solutions to the worldwide problem of water scarcity. However, the main barriers to the general adoption of desalination systems are the substantial upfront technology costs, and the large amount of energy that is needed for the technological processes. The major goal of AQUASOL is to develop a technological platform that enables the massive penetration of renewable energy sources into the desalination technology with no impact on the power network and providing disruptive, energy-efficient solutions for saline/brackish water pre-treatment and filtration, as well as brine and wastewater recycling. The system will be supplied with hybrid energy storage system and connected to the modular fault-tolerant multiport converter. This approach will help not only to reduce number of power electronics converters, provide both long-term and short-term energy storage capabilities, stabilize the system against intermittent renewable energy inputs but also support grid-independent operation in remote or island scenarios. A combination of novel two-dimensional material-based membranes and specific chemicals for seawater and wastewater treatment will be developed. To maintain minimum energy consumption during operation, the model-based energy management system will be developed, too. This closed-loop approach minimizes waste and maximizes resource utilization for irrigation in agriculture. The concept will address and investigate societal challenges of technology adoption and measures to overcome identified challeges

Keywords: green desalination,energy efficient water solutions,water for agriculture,cost effective technology,social life cycle analysis
Extreme Food Risk Analytics (EFRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Sweden,Netherlands,Croatia,Romania,United Kingdom
Call: Extreme data mining, aggregation and analytics technologies and solutions (RIA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4833797.5
EU funding (EUR): 4833797.5
Participants: 9
Project status: SIGNED

EFRA will explore how extreme data mining, aggregation and analytics may address major scientific, economic and societal challenges associated with the safety and quality of the food that European consumers eat. EFRA’s goals are: i) develop and test solutions to discover and distil food risk data from heterogeneous and dispersed/scarce data sources with minimal delay and appropriate format; ii) design relevant human aspects & interactions with users to measure usefulness for human risk prevention actions in real-world use-cases iii) demonstrate how solutions enable the development of trustworthy, accurate, green and fair AI systems for food risk prevention iv) achieve groundbreaking advances in performance and effectiveness of food risk data discovery, collection, mining, filtering, and processing; v) integrate relevant technologies (big data, IoT, AI) to foster links to food data innovator communities vi) position its contributions into the overall ecosystem of public & private stakeholders that share data, technology and infrastructure to ensure the safety and quality of food in Europe. To achieve these goals, EFRA will design, test, and deploy tools and undertake appropriate initiatives to facilitate their uptake, elicit feedback, and engage stakeholders. The EFRA tools are: (i) EFRA Data Hub, offering intelligent crawlers and data annotation & linking modules to search, mine, process, annotate, and link dispersed, multilingual, heterogeneous, and deep/hidden food safety data sources (ii) EFRA Analytics Powerhouse: offering modules running over a green cloud HPC that distil useful insights & signals from the EFRA Data Hub to train privacy-preserving, explainable, green food risk prediction AI models (iii) EFRA Data & Analytics Marketplace: A front-facing user-friendly web app that allows interested users to discover, purchase/use, and contribute data, AI models, and analytics modules, creating an economy where data holders and data consumers engage and trade.

Keywords: food safety,risk predictions,extreme data,data platform,data space,ai,big data,hpc,green infrastacture,nlu nlp
Open data and industry driven environment for multiphase and multiscale Materials Characterization and Modelling combining physics and data-based approaches (MatCHMaker)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: France,Italy,Romania,Norway,Spain,Germany,Belgium,Austria
Call: Advanced materials modelling and characterisation (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 4700233.5
EU funding (EUR): 4700233.5
Participants: 12
Project status: SIGNED

The MatCHMaker project is determined to support excellence in research on methods and tools for advanced materials development. MatCHMaker will enable the integration and interoperability of complex C&M workflows matching the needs of EU manufacturing industry. Requirements on multiphase and multiscale materials coming from Construction, Energy and Mobility sectors will be translated into specific innovation challenges that can be addressed by an integrated approach combining characterization and (physics and data-based) modelling for establishing the process-microstructure-macroscopic properties correlation in advanced materials in a reproducible and efficient way reducing development costs, time and risks while improving sustainability. Knowledge transfer, data sharing and full interoperability between C&M “communities” will be facilitated using data related standards (CHADA, MODA, EMMO) and by the creation of an open repository with connection to design and manufacturing processes. The repository will be based on Semantic Web to represent rich and complex ontologies. EMMO is the starting point, domain and application ontologies related to MatCHMaker use cases and providing a fully semantical vocabulary to describe the produced C&M data will be developed. Standardisation of MatCHMaker ontologies, data documentation and domain ontologies will be sought via engagement in specific activities (e.g. collaboration with EMMC, EMCC, OntoCommons CSA). The ambition of MatCHMaker is to validate project results on three Use Cases (UC) representatives of low carbon and clean industry: UC1\Construction\Cement; UC2\ Energy\ Solid Oxide Fuel Cells/Solid Oxide Electrolysis Cells (SOFC/SOEC); UC3\ Mobility\Proton-Exchange Membrane Fuel Cells (PEMFC). The project will foster synergies and interaction with EMMC and EMCC to align MatCHMaker results to councils’ objectives.

Keywords: characterization and testing,physic based modelling,data based modelling,machine learning,materials sustainability,open repository,ontology,interoperability,materials design
NeuroProtective role of HRI following cerebral ischemia (NeuProHRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Nowadays, cerebrovascular diseases are devastating conditions representing a large cause of mortality worldwide. It is estimated that 1.1 million people suffer a stroke every year in Europe. Due to the lack of a reliable treatment for stroke, it is important to keep looking for new treatments that stop the progression of the insult by providing neuroprotection, and even promote neuronal recovery for those neurons already affected by the condition. The goal of NeuProHRI is to study the potential of targeting the HRI kinase cellular cascade as a new therapeutic aim for stroke. To develop this, I will use a combination of cutting-edge molecular techniques to define the cellular pathways underlying the activation of the HRI kinase, and their effect on promoting neuroprotection in in vitro and in vivo models of stroke. First, I will decipher the molecular cascade following the activation of HRI in primary cultured neurons by pharmacological and genetic approaches. Then, in vitro models of stroke will be used to measure the impact of these treatments in cells with stroke-like phenotype. Finally, mouse models of stroke will allow me to tackle the impact of pharmaceutical and genetic treatments on in vivo brain tissue. Moreover, Ribo-seq analysis will be performed to study accurately protein synthesis and its relation to neuron-intrinsic pathways involved in stroke. There is a clear benefit of the mobility for both the applicant and the host, ensuring high quality results and dissemination. In this regard, the host will ensure the acquisition of new technical, management, tutorial and transferable skills. The applicant will also benefit from a multidisciplinary environment enhancing international collaboration that will surely contribute to diversify his career. Finally, via a specialized Career Development Plan, the host will provide the ideal training and validation environment, through which the applicant will reach unprecedented levels of professional maturity.

Keywords: stroke,er stress,eif2a,hri,btdcpu,neuroprotection,ribo seq
Hybrid Dye sanitised solar cell -Electrochemical Cell System for Simultaneous Energy Generation and Carbon dioxide Capture: A Novel Approach for Sustainable Energy Production (SHAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Project SHAPE (Solar Harnessing for Advanced energy Production and Emission capture) will develop a novel solar cell system involving two major innovations: an advanced power production cell and an integrated carbon dioxide (CO2) capture cell. The system will utilize third-generation photovoltaic technology, specifically a dye-sensitized solar cell (DSSC), with a common cathode, which will simultaneously serve as the CO2 conversion cell anode. This innovative design will allow the integrated system to achieve unassisted CO2 reduction to CO under solar irradiation, whist the power production element will achieve greater efficiency than current technologies, along with enhanced sustainability and safety. SHAPE is focused on the ambitious objective of a dual-purpose device, delivering simultaneously solar-driven carbon dioxide conversion and sustainable energy generation and storage, offering a novel technology capable of contributing towards the goal to achieve a climate-neutral Europe by 2050.

Keywords: perovskite solar cell,natural dyes sensitized solar cell,carbon capture,deep eutectic solvents
Reconstitution of Crista Junction proteins using DNA origami-based Molecular Scaffolds for Structural and Functional analyses (DNA-MolScaff)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Mitochondrial cristae are functional dynamic compartments containing the respiratory chain complexes where oxidative phosphorylation occurs. They are separated from the inner boundary membrane by highly curved and tightly regulated membrane compartments called crista junctions (CJs). A key multi-protein complex, mitochondrial contact site and cristae organizing system (MICOS), is enriched in CJs and plays a central role in modulating the architecture and function of CJs. Recently, a MICOS subcomplex built by the Mic60-Mic19 tetramer was proposed to traverse the CJ like a molecular strut and hypothesized to act as a diffusion barrier for metabolites and proteins between the inner mitochondrial membrane and the cristae lumen. However, the exact location of this MICOS subcomplex in CJs, its proposed diffusion barrier function and its detailed role in modulating CJ architecture are not clear. Here, I propose to fabricate a CJ mimic to reconstitute the Mic60-Mic19 tetramer into an octagonal donut-shaped DNA origami scaffold. The surface of the DNA origami will be coated with a lipid monolayer, enabling stabilization of the reconstituted complex, and facilitating structural studies using cryo-electron microscopy (cryo-EM). Subsequently, the role of Mic60-Mic19 complex and its intrinsically disordered regions as a diffusion barrier will be probed by incorporating the CJ mimics onto the surface of the liposomes. These efforts will reveal the structure of the Mic60-Mic19 subcomplex in a near-native environment and its role in the transport of proteins and metabolites, thereby providing an in-depth understanding of its cellular function. The realization of membrane-coated DNA origami molecular scaffolds as platforms for reconstituting proteins may pave the way for nano-tools that are made from DNA for structural and functional exploration of other challenging membrane and membrane-interacting proteins, which could yield valuable insights into key biological processes.

Keywords: dna origami,cryo em,mitochondrial cristae junctions,micos,dna aptamers,dna protein interactions,diffusion experiments
Vascular Interactions and Remodeling during Gestation and its Impact on Neuronal functions (VIRGINS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1999039.0
EU funding (EUR): 1999039.0
Participants: 1
Project status: SIGNED

An intricate network of blood vessels perfuses the brain to support neural cells and carry signaling molecules from the periphery. It is mainly considered a rigid “transportation network” rather than a dynamic and plastic “information network” integrated to neurons and glia. This proposal revisits this concept and aims to define the nature of vascular remodeling in healthy brains (i) and which remodeling mechanisms play a role in shaping plastic neuronal functions (ii) The project VIRGINS explores this in the context of the neurophysiological adaptations occurring during and after pregnancy. There, sexual hormones promote neuronal plasticity, which tunes the cerebral control of energy balance, and drives the emergence of parental behaviors. Using our unbiased whole-brain vascular mapping technique TubeMap, we found that in pregnant mouse brains, vascular territories of regions controlling energy homeostasis and hormonal states are remodeled: the Arcuate, PeriVentricular, ParaVentricular, and DorsoMedial nuclei of the Hypothalamus. We also found remodeling of blood vessels in brain regions processing pup calls: the auditory and prefrontal cortex, the hippocampus, and subcortical relays. The regional specificity of this vascular plasticity suggests precise and complex regulatory mechanisms and a role in shaping neuronal functions in the pregnant state. To link structural, functional, and molecular changes in the neurovascular unit during gestation, we will use light sheet brain mapping, neurovascular (fast ultrasounds), and 2-photon imaging with transcriptomics, molecular and behavioral tools to determine 1) the nature of whole brain vascular plasticity during pregnancy, 2) its mechanisms and impact on the control of energy homeostasis and 3) its role in the tuning of the auditory system to infant calls. This project will transform our view on the capacity of the NeuroVascular Unit to sculpt neuronal computation and behaviors.

Keywords: vascular biology,pregnancy,plasticity,metabolism,auditory systems,neuroendocrinology,light sheet microscopy,brain mapping,neuroanatomy
Baths’ Architecture in Late Antique Sicily: Natural Resources and Economic Sustainability (BALNEa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2029-01-31
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 3
Project status: SIGNED

The project will be hosted by the University of Bologna's Department of History and Cultures, supervised by Prof. Isabella Baldini, a leading scholar in Late Antique archaeology. It aims to investigate the decline of Roman public baths (balnea, in Latin). Baths held a crucial role in fostering sociability, being accessible to all social classes, thus becoming integral components of urban landscapes. While their decline during Late Antiquity is often attributed to cultural shifts tied to the rise of Christianity, my research aims to uncover environmental and economic factors that contributed to this decline. My study will chiefly concentrate on spatial volume of the thermal bath’s rooms, the energy consumption required for their heating, and the production cycle for procuring fuel materials within specific ecological settings. I’ve chosen Sicily as a case study due to the context comparable with other Mediterranean regions and the wealth of thermal complexes unearthed, a suitable number within the 3-year MSCA-PF. Methodologically, the research will first rely on the available scientific literature on the topic. Subsequently, drawing upon my background as an architect, I will delve into the technical and stylistic aspects of energy-efficient practices in designing ancient buildings, utilizing technologies such as surveying, 3D reconstruction, and simulations. The archaeological remains will be analysed through the creation of digital models to reconstruct their structural characteristics and operational system performance. To acquire the latest survey and 3D reconstruction technologies, I will conduct the Outgoing phase at the ‘Institute for Digital Exploration’ at the University of South Florida, directed by Prof. Davide Tanasi. Additionally, during a Secondment at the University of Catania’s ‘Energy Sustainability & Environmental Control Laboratory’, guided by Prof. Francesco Nocera, I will assess energy efficiency and economic sustainability in ancient buildings.

Keywords: late antiquity late antique baths roman baths archaeology of architecture 3d models simulations ancient energy efficiency ancient economic sustainability architectural energetics
“integrated software toolbox for secure IoT-to-Cloud computing” (INTACT) (INTACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Ireland,France,Romania,Austria,Germany,Greece,Switzerland,Cyprus,Bulgaria,Slovenia,United Kingdom
Call: Secure Computing Continuum (IoT, Edge, Cloud, Dataspaces) (HORIZON-CL3-2023-CS-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 7080270.0
EU funding (EUR): 5644566.75
Participants: 19
Project status: SIGNED

We will develop an Integrated Software Toolbox that will offer predictive Cybersecurity sensing, optimization and management services for the distributed IoT-to-Cloud continuum. The scope is to continuously maximizing the continuum’s infrastructure security and data privacy with minimal effect on its computing capacity, energy consumption, monetary costs, etc. that are necessary for the businesses to run. To do so, Twinning tools will be replicating the continuum as virtual (isolated) dataspaces, such that Threat Intelligence tools can stress-test the attack-surface of these dataspaces and predict optimal risk mitigation measures accurately and safely (i.e. pre-emptively protecting and without affecting the real system operation), subject to certain computing, energy, etc. thresholds set by the end-user. Scalability & Interoperability of services and data will be achieved via the use of open standards & APIs (including Eclipse Connector), while AI Automation will be embedded in all Toolbox processes. Identity & Access Management will be advanced over a zero-trust distributed computing pipeline covering all Hardware-, System-, and Application-level security. An initial Lab-testbed with matured DevSecOps & ML/Data-Ops stemming from previous EU Actions will lead our developments roadmap to 4x + 1 final TRL7 operational deployments that will be validated over 1st & 2nd Stage Demos covering use cases related to Telcos, Health 4.0, Transportation, Safety-critical Nuclear Infrastructures, and Smart Cities (cross-vertical supply-chain assessments). The impact will not only safeguard EU position in data security, economy and applications verticals, but lower energy efficiency and CO2 footprint. Sustainability & Industry acceptance will be achieved via open source ecosystems, standardization involvement, and a dedicated Portal for linking our dataspaces to EU Data Spaces (GAIA-X, IDSA, etc) and our innovations to EU Bodies related to Cybersecurity, AI, IOT and Robotics.

Keywords: predictive threat intelligence,integrated software toolbox,joint cybersecurity and computing optimization,digital twins,artificial intelligence,zero trust distributed computing