Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Healthy Textile (Healthy Textile)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-08-01
End date: 2022-01-31
Duration (months): 30.0
Total project cost (EUR): 3361250.0
EU funding (EUR): 2352875.0
Participants: 1
Project status: CLOSED

The World Health Organisation has identified that there are many textiles items used in hospitals being the main cause for Nosocomial infections (Hospital Acquired Infections-HAI). Nosocomial infections are one of a major global health concern being related with hospitals’ used textiles to be one of its primary causes. Nosocomial infections can result in prolonged hospital stays, long-term disability, and increased resistance of microorganisms to antimicrobials, therefore it presents massive additional costs for health systems, high costs for patients and their family, and unnecessary deaths. In Europe alone every year about 5 million patients suffer from a Nosocomial infection out of which about 50,000 people may die, causing an annual financial burden of €7 Billion in direct costs. Healthy-Textile is a breakthrough powerful and permanent Zinc-oxide Antibacterial coating for Textiles based on the physical phenomena “Cavitation” - a High velocity implosion of voids/bubbles inside of a liquid solution, resulting in powerful micro jet-streams of over 500 meters/second which are impregnating the required chemistry molecules onto Textile fibers (“Sono-Coating”). Nano Textile’s technology is considered to be a game changer in the sense that for the first time in the world (patented), there is an effective Antibacterial coating for all Medical Textiles which is durable for Industrial washings, cost effective, and applicable to all Textile types. Healthy-Textile will prevent the spread of infectious diseases by eliminating bacteria, viruses and fungus, and even antibiotics resistant bacteria, and can transform any fabric into a protective shield against HAI for the patient. The patented technology permanently prevents the growth of bacteria on both natural and synthetic fabrics, prevent the spread of HAI and can reduce cross contamination between patients and medical staff.

Keywords: healthy textile
Performance optimization of two-phase passive loop system (POTPLOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Innovative heat transport devices are needed to break-though the increasing need for smaller, faster and lighter microelectronic apparatus. A Pulsating Heat Pipe (PHP) is a promising two-phase passive loop device that has many advantages such as high heat transfer capacity, construction simplicity, lightweight, and low-cost. However, the practical use of PHP has been limited due to insufficiency of design tools, i.e. predictive models for hydrodynamic and heat transfer phenomena. The aim of this proposal is to establish a universal model to predict operating limit of PHP and provide an optimal design solution that maximize PHP heat transport capability. An innovative approach using advanced measurements with high-resolution and high-speed infrared cameras and Inverse Heat Conduction Problem (IHCP) techniques will be taken to reveal the local thermal phenomena of the liquid-vapor interaction and obtain important physical parameters to implement the model. Both an experimental and a modelling approach will be used to reach the project goal. The project will bring together two complementary set of skills, with the researcher’s expertise in PHPs and the supervisor’s expertise in thermal tomography. In addition, a secondment in a leading company of two-phase thermal devices is foreseen, to increase the researcher’s competence in manufacturing and testing. The fellowship will support the researcher’s professional development to be a leader in the thermal fluid dynamics field. The impact of the action will be maximized with scientific publications as well as a broad range of outreach activities such as video pills and public talks to non-technical audiences, with a special target to young females to booster research careers in technology and engineering. Results of this MSCA have the potential to strengthen the European research and industrial leadership, promoting the use of PHP in several industrial applications, including aerospace, automotive and energy sectors.

Keywords: two phase flow,thermal engineering,pulsating heat pipe,thermal tomography,infrared analysis,inverse heat conduction problem
Organ-specific mechanisms of lymphatic vascular development and specialisation (LYMPHORG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 2368439.0
EU funding (EUR): 2368439.0
Participants: 1
Project status: CLOSED

Lymphatic vasculature maintains tissue fluid homeostasis and has important emerging roles in inflammation, immunity, lipid metabolism, blood pressure regulation and cancer metastasis. Lymphatic vessels are specialised to fulfil the functional needs of different organs while diseases associated with lymphatic dysfunction frequently affect vessels of specific tissues. How functional specialisation of vessels is achieved and what underlies tissue-specific vessel failure is not understood. I hypothesise that organ-specific manifestation of lymphatic dysfunction in disease is due to vascular bed-specific differences in vessel formation. In this project my aim is to identify genes and mechanisms required for organ-specific lymphatic development. Building on our recent discovery of a previously unknown progenitor cell type that is required for lymphatic development in an organ-specific manner I set out to identify the origin and function of lymphatic endothelial progenitor cells (LEPC) during development and assess their potential for therapeutic lymphatic regeneration. Towards this aim, we will identify organ-specific origins of lymphatic vasculature using lineage tracing and determine genetic signatures of lymphatic endothelial progenitors by mRNA sequencing. Cells and tissues from normal and mutant mice that show organ-specific lymphatic defects will be analysed. To identify molecular and cellular mechanisms of LEPC derived vessel formation, we will functionally characterise LEPC signature genes using mouse models and visualise vessel development by in vivo two-photon microscopy. The function and therapeutic potential of LEPCs and LEPC derived vessels will be assessed using mouse models of tolerance, inflammation, obesity and lymphoedema. This work will provide novel insights into organ-specific mechanisms of vascular morphogenesis and identify a progenitor cell that may be expoited to restore lymphatic function in disorders associated with lymphatic vessel failure.

Keywords: vascular biology,lymphangiogenesis,lymphatic vessel,lymphoedema
Dark-Soliton Engineering in Microresonator Frequency Combs (DarkComb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2023-10-31
Duration (months): 66.0
Total project cost (EUR): 2259522.5
EU funding (EUR): 2259522.5
Participants: 1
Project status: SIGNED

The continuing increase in Internet data traffic is pushing the capacity of single-mode fiber to its fundamental limits. Space division multiplexing (SDM) offers the only remaining physical degree of freedom – the space dimension in the transmission channel – to substantially increase the capacity in lightwave communication systems. The microresonator comb is an emerging technology platform that enables the generation of an optical frequency comb in a micrometer-scale cavity. Its compact size and compatibility with established semiconductor fabrication techniques promises to revolutionize the fields of frequency synthesis and metrology, and create new mass-market applications. I envision significant scaling advantages in future fiber-optic communications by merging SDM with microresonator frequency combs. One major obstacle to overcome here is the poor conversion efficiency that can be fundamentally obtained using the most stable and broadest combs generated in microresonators today. I propose to look into the generation of dark, as opposed to bright, temporal solitons in linearly coupled microresonators. The goal is to achieve reliable microresonator combs with exceptionally high power conversion efficiency, resulting in optimal characteristics for SDM applications. The scientific and technological possibilities of this achievement promise significant impact beyond the realm of fiber-optic communications. My broad international experience, unique background in fiber communications, photonic waveguides and ultrafast photonics, the preliminary results of my group and the available infrastructure at my university place me in an outstanding position to pioneer this new direction of research.

Keywords: fiber optic communications,optical frequency comb technology,microresonator frequency comb
Pharmacological safety testing in human adult stem cell-derived organoids (TOXANOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands,Netherlands
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 147500.0
EU funding (EUR): 147500.0
Participants: 2
Project status: CLOSED

Toxicology and pharmacology assays are crucial pillars of modern drug development. They are essential to understand how tissues such as intestine and liver take up and degrade pharmaceutically active compounds. Due to the lack of suitable in vitro systems, these assays are carried out in experimental animals. This practice increases cost and development time but also creates significant ethical issues. We recently developed a 3D culture system that allows us to expand human tissue stem cells from intestine and liver as organoids and differentiate them to the respective functional adult tissue in vitro. These stem cell-derived tissues show high cytochrome activity and are able to metabolize drugs in a simple and cost-effective in vitro assay. With support from the ERC Proof of concept grant we aim to prove that our technology can outperform current in vitro systems and replace a significant portion of animal-based toxicology studies. This technological advance will lead to substantial reduction of cost in industrial and academic drug development and overcome practical and ethical pitfalls in animal-based testing. To this end we will develop an organoid-based assay to test tissue-drug interactions in three steps: 1) Definition of optimal parameters for human in vitro assays to assess gastro-intestinal and hepatic toxicity 2) Scale-up 3) Technology transfer and commercial distribution

Keywords: stem cells,organoids,toxicology
NLRP3 in cancer: Deciphering the role of NLRP3 in the DNA Damage response pathway (RoNDBioCan)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-04-21
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

Cancer represents one of the main causes of death in the European Union (WHO). Particularly, non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer-related death worldwide. Despite significant therapeutic improvements, the survival rate of patients with advanced stage NSCLC remains dismal, signifying a critical need to elucidate the molecular processes driving NSCLC. Inflammasomes are major drivers of inflammatory responses and are deregulated in a wide range of disorders, yet their participation in carcinogenesis is largely unknown. Genome analyses reported that the NLRP3 receptor, component of the NLRP3 inflammasome, is affected by somatic alterations in 20% of NSCLC. Moreover, recent evidence has shown that NLRP3 is essential for the activation of the ATM/CHK2 pathway in response to double strand breaks (DSBs), while its expression is systematically absent in NSCLC cells. Based on these data, we hypothesize that NLRP3 is a key factor in the DDR pathway to DSBs and in the maintenance of genome integrity in lung epithelial cells, and as a consequence may play a key tumor suppressor role. The objectives of RoNDBioCan will be to decipher the molecular mechanism of NLRP3 function in the DDR pathway and to evaluate the therapeutic potential associated with NLRP3 expression. By characterizing novel NLRP3 partners and examining the impact of NLRP3 re-expression on tumor development in vivo, RoNDBioCan will significantly improve the current knowledge regarding NLRP3 participation in lung cancer. Given that the poor outcome associated with NSCLC is mostly due to limited curative options, there is an urgent need to identify new biomarkers and additional treatments to reduce the current burden of lung cancer. This work will thus considerably contribute to the development of new effective and personalized therapeutic approaches to help improve the prognosis of lung cancer patients.

Keywords: nlrp3 receptor,non small cell lung cancer,dna damage signaling,biomarker
Targeting the essentialome of radiotherapy-resistant cancer (TETHER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

More than 50% of the cancer patients undergo irradiation as part of their cancer treatment. Although radiotherapy (RT) significantly contributes to cancer cure, local therapy resistance and the subsequent emergence of distant metastasis remain major obstacles for its success. The molecular mechanisms underlying tumor cell-intrinsic RT resistance are ill-defined. It is therefore crucial to better define these mechanisms and identify new vulnerabilities of RT-resistant tumors in order to decrease the current annual cancer mortality of >1.3 million persons in EU member states alone. In the TETHER project, I will address the problem of RT resistance by synergizing the power of genetic essentiality analyses with unique mouse models and organoids that we have established. We recently found that members of the shieldin and CST complexes are essential for tumor cells to survive irradiation, while causing PARP inhibitor resistance when lost in BRCA1-deficient tumors. Based on this unexpected finding, I have started a new line of research to dissect the RT "essentialome". As I show with the discovery and functional characterization of ERCC6l2 as a novel DNA repair factor in this network, the technology we have in place is perfectly suited to tackle this question. In addition, we will apply distinct CRISPR/Cas9-based tests to map the functional interactome of genes that are essential for RT resistance. To follow the plasticity and RT escape of tumor cells in vivo, we have also developed innovative model systems. Similar to the situation in cancer patients, we observe that residual cancer cells in our mouse models escape the deadly effects of RT by local resistance or metastasis formation. Thus, these models provide a unique opportunity to explore and target RT escape mechanisms. I am convinced that the combination of these state-of-the-art approaches will yield highly useful information for designing individualized approaches to improve RT response in cancer patients.

Keywords: radiotherapy resistance,breast cancer,dna repair,crispr,essentialome,synthetic lethality,functional genomics,3d organoid cultures,genetically engineered mouse models,residual disease,metastasis,homologous recombination,non homologous end joining
Network Motion (NEMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2498529.0
EU funding (EUR): 2498529.0
Participants: 1
Project status: SIGNED

NEMO, NEtwork MOtion, is an inter-disciplinary proposal centered on network dynamics. The inter-disciplinarity spans from communication engineering to mathematics, with an innovative interplay between the two. NEMO’s focus is on stochastic geometry. This emerges as one of the most important new conceptual and operational tools of the last 10 years in wireless networking, with a major academic and industrial impact on architecture, protocol design, planning and economic analysis. Nevertheless, the state of the art is unable to cope with the dynamics introduced in recent and future network functionalities. NEMO’s aim is to introduce dynamics in wireless stochastic geometry. The dynamic versions of stochastic geometry to be developed will capture these new functionalities and specifically tackle two core promises and challenges of the future of wireless networking: that of ultra-low latency networking, required for enabling the unfolding of future real time interactions, and that of draining to the Internet the unprecedented amount and structure of data stemming from the Internet of Things. Several fundamental types of random network dynamics underpinning these functionalities are identified. General mathematical tools combining stochastic geometry, random graph theory, and the theory of dynamical systems will be developed to analyze them. This will provide parametric models mastering the complexity of such networks, which will be instrumental in addressing the above challenges. The aim is to have, through these dynamical versions, the same academic and industrial impact on wireless networks as static stochastic geometry has today. NEMO will leverage structural interactions of INRIA with Ecole Normale Supérieure on the mathematical side, and with Nokia Bell Labs and Orange on the engineering side. This will create in Europe a group focused on this mathematics-communication engineering interface, and to become the top innovation group of the field worldwide.

Keywords: stochastic geometry,dynamical systems,random graphs,information theory,queuing theory,wireless networks,cellular networks,internet of things,performance guarantees in networks
MicroFluidic based platform for SeMen Analysis (MicroFSMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

MicroFSMA aims to deliver an assay for semen analysis and isolation of quality sperm for in-vitro fertilization (IVF). An automated, user-friendly, standardized, and efficient method is highly in demand from embryologists/andrologists. MicroFSMA consists three microfluidic chips integrated with a commercial computer program. Microfluidics chips will be designed to replicate in-vivo physical and chemical environment of a female reproductive tract. The thermal and chemical gradient will be generated in microchannels to identify responsive sperm cells. Additionally, a computer program will facilitate multi-sperm head and flagella tracking for the recorded time-lapse image sequence. Tracking algorithm will connect the positions of sperm cells in recorded successive images. The continuous wavelet analysis (CWT) /harmonic analysis of the flagellar wave and head trajectory will assist to identify the responsive sperm cell towards the chemical/physical cues. We are convinced that the correlation of sperm kinematics with harmonics/wavelet analysis will reveal potential parameters for male infertility screening. The successful employment of MicroFSMA in an industrial atmosphere will improve the experienced researcher (ER) knowledge of industrial R&D and market strategy. These unconventional skills will ensure the complete exploitation of MicroFSMA results by starting the small-medium enterprise(SME)/academic joint research schemes.

Keywords: microfluidics,semen analysis