Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Epigenome Maintenance on Sister Chromatids (EpiMoSis)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1665563.0
EU funding (EUR): 1665563.0
Participants: 1
Project status: SIGNED

DNA replication not only involves the copying of the genome to propagate cell identity to daughter cells but also of the epigenome, where histones and their post-translational modifications (PTM) are accurately maintained in replicated chromatin. This is achieved by a strikingly coordinated process that ensures accurate, symmetric recycling of H3-H4 tetramers to both daughter strands, thus forming the basis of epigenetic memory. Recently, I identified H2A-H2B PTMs to be also symmetrically recycled in a H3-H4-independent manner. The underlying mechanism and their role in epigenetic memory remain unclear. Moreover, whether the asymmetric nature of DNA replication (leading vs. lagging strand) leads to asymmetric chromatin landscapes on daughter strands per se remains unexplored due to the current lack of technologies. I hypothesize that propagation of cell identity to daughter cells requires crosstalk of conserved “memory modules” (on H3-H4 and H2A-H2B) to equilibrate the asymmetric mode of DNA replication. We will use both stem cell culture and fission yeast to define evolutionarily conserved concepts of chromatin restoration after replication. To this end, we will extend state-of-the-art sequencing, proteomics, genome editing, as well as established and novel nucleotide labelling approaches. First, we will address the molecular mechanism of H2A-H2B PTMs recycling during replication. Second, we will test the role of active chromatin PTMs in maintaining chromatin states, 3D chromatin organization, and gene expression after replication. Third, we will develop a novel strand-specific labelling technology to determine the composition and restoration principles of leading and lagging strand-replicated chromatin. This proposal will directly dissect the function and relevance of epigenetic memory on H2A-H2B and active chromatin PTMs post-replication and define new concepts of how chromatin maintenance mechanisms promote symmetric cell division and support cell identity.

Keywords: dna replication,functional genomics,histone modifications,asymmetric cell division
Politics of Conservation and Unequal Ecological Exchange in European Peripheries (GreenFrontier)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1499976.25
EU funding (EUR): 1499976.0
Participants: 1
Project status: SIGNED

GreenFrontier will radically transform understandings of how strict protection of nature remakes human-environment relations in Europe’s marginal areas by developing a novel field of inquiry - political ecology of conservation frontiers. It breaks new grounds from research on frontier commodities by showing that uneven power relations within the EU’s conservation vision create a new resource – wilderness, essential for future green growth. The project’s pioneering and high-risk research design combines approaches from three disciplines –anthropology, history and politics. Its main research question is: How does a green growth vision based on strict protection of biodiversity affect human-environment relations in Europe’s marginal areas? GreenFrontier is urgently required because the EU's visions of green growth, which includes earmarking 10% of the EU’s land area for strict protection by 2030, raise serious issues of social and environmental injustice: involuntary changes to livelihoods, forced displacement, marginalisation and decline of traditional ecological knowledge. The project will investigate how strict protection of nature reshapes socio-environmental relations in the following mountain regions often overlooked by academic debates: the Southern Carpathians in Romania, the Central Apennines in Italy, the Central Cantabrians in Spain, and the Bieszczady in Poland. The project moves beyond the state of the art and explores new analytical frameworks to understand European conservation frontiers within their specific genealogies of land use change and as part of the current political momentum of green growth imperatives within the EU. GreenFrontier challenges the mainstream understanding of commodity frontiers as happening in the global South. Instead, it focuses on how the EU's green growth vision produces in Europe non-intervention zones where strictly protected carbon- and biodiversity-rich areas become essential fixes for multiple planetary crises.

Keywords: political ecology,conservation,environmental justice,land abandonment,rewilding,protected areas
nExt geNeration 1200V eLectric hIGH volTage powErtraiN (Enlighten)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Austria,Czechia,Italy,France,Denmark,Germany,United Kingdom,Switzerland
Call: Integration and testing of next generation post-800V electric powertrains (2ZERO Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 5952265.25
EU funding (EUR): 5952265.25
Participants: 11
Project status: SIGNED

ENLIGHTEN aims at developing, integrating and testing a next generation post 800V electric vehicle powertrain with an indicative voltage level of 1200V. It targets a higher performing, cost optimized and more sustainable drivetrain layout that is also backwards compatible to the existing charging infrastructure with 1000V or 500V respectively. Determining exactly how high the new voltage level should be, to enable expected advantages in a systemic and systematic way is also part of the project. A new voltage level affects the entire sphere of electric mobility, both horizontally (vehicle, charging infrastructure, users, manufacturers) and vertically (OEM, tier1, tier2, single component supplier), hence a deliberate decision is required. To accomplish this an advanced electrical system architecture is presented by the ENLIGHTEN consortium in this proposal on whose basis a specific electric vehicle drivetrain will finally be developed and demonstrated in a C-segment vehicle. The at TRL5 delivered powertrain will consist of a dual voltage battery system and an integrated motor-inverter E-drive system, complemented by an intermediate DCDC converter, an AC and DC capable onboard charger and a power distribution. All power electronic devices will exploit low loss, ultra-fast switching gallium nitride (GaN) semiconductors for highest efficiency and to minimize cooling demand and component size. The dual voltage battery can be switched dynamically from one battery voltage into the other while driving. Through these and other measures, the ENLIGHTEN system delivers significant advances over the 2024 State of the Art. The ENLIGHTEN consortium includes 2 automotive companies, 1 Tier1 supplier and 2 SMEs. Their expertise is leveraged by the partnership with 2 research institutions and 4 academia/universities, constituting an ideal setup for strengthening the competitiveness of the European automotive industry.

Keywords: gan 1200v powertrain inverter multilevel battery
Language Augmentation for Humanverse (LUMINOUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Switzerland,United Kingdom,Ireland,Greece,Netherlands
Call: Next Generation eXtended Reality (RIA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 5603706.25
EU funding (EUR): 5603706.25
Participants: 12
Project status: SIGNED

LUMINOUS aims at the creation of the next generation of Language Augmented XR systems, where natural language-based communication and Multimodal Large Language Models (MLLM) enable adaptation to individual, not predefined user needs and unseen environments. This will enable future XR users to interact fluently with their environment, while having instant access to constantly updated global as well as domain- specific knowledge sources to accomplish novel tasks. We aim to exploit MLLMs injected with domain specific knowledge for describing novel tasks on user demand. These are then communicated through a speech interface and/or a task adaptable avatar (e.g., coach/teacher) in terms of different visual aids and procedural steps for the accomplishment of the task. Language driven specification of the style, facial expressions, and specific attitudes of virtual avatars will facilitate generalisable and situation-aware communication in multiple use cases and different sectors. LLMs will benefit in parallel in identifying new objects that were not part of their training data and then describing them in a way that they become visually recognizable. Our results will be prototyped and tested in three pilots, focussing on neurorehabilitation (support of stroke patients with language impairments), immersive industrial safety training, and 3D architectural design review. A consortium of six leading R&D institutes experts in six different disciplines (AI, Augmented Vision, NLP, Computer Graphics, Neurorehabilitation, Ethics) will follow a challenging workplan, aiming to bring about a new era at the crossroads of two of the most promising current technological developments (LLM/AI and XR), made in Europe.

Keywords: extended reality,artificial intelligence,zero shot learning,computer vision,situational awareness,natural language processing,large language models,digital health
Integrated photonic circuit fabrication by femtosecond laser writing for quantum information (PhotonFAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Quantum technologies promise to revolutionize the way we acquire, manipulate and communicate information. Photons are key players in quantum technologies with a transversal role in all applications. In particular, integrated photonics is the only viable approach to scale up quantum photonics to the level of real-world applications. In this context, many materials and fabrication tecnologies are being explored. Among them femtosecond laser writing of photonic circuits in transparent glasses is a powerful microfabrication technique with several advantages that could particularly benefit quantum applications. In particular, in a rapidly developing field such as that based on quantum technologies, there is a great need for rapid prototyping, easy customization and versatility in terms of layouts, materials and applications; all these features are specifically provided by femtosecond laser writing. In this project we would like to build from several key device demonstrations, achieved in the main ERC Advanced Grant, to develop their potential for commercial exploitation in the globally expanding market of quantum photonic devices. Femtosecond laser writing has already demonstrated its industrial viability with several existing companies based on this technology, however, none of them tackles the market of quantum integrated photonic devices. The PI and his team have a longstanding experience in designing and producing integrated photonic devices for quantum applications. The PhotonFAB project will focus on improving the production capability in terms of circuit complexity, efficiency and packaging. Together with a thorough market and IPR analysis, contacts with potential end users and stakeholders, and detailed cost estimation, this project will help shaping the exploitation strategy of the many groundbreaking results achieved in the ERC Advanced Grant project.
Quantum Simulation with Universal Nonlinear optics (QSun)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-06-30
Duration (months): 33.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Quantum information processing is a transformative technology that will address societal needs by obtaining unprecedented computational power with quantum computers and simulators, unconditionally secure quantum communications, and quantum-enhanced sensors. Photons play a central role in the development of quantum technologies due to their unique capability to encode quantum information with low-noise, transmit it over long distances, and process it in scalable photonic circuits. However, the lack of photon-photon nonlinearities poses a central challenge in the development of photonic quantum technologies. The aim of this proposal is to address this limitation for next-generation quantum photonic devices. The enabling technology is the combination of two quantum photonic platforms: light-matter interactions with quantum dot emitters in integrated nanostructures, and programmable quantum photonic circuits performing universal transformation in the temporal degree of freedom. Through the use of high-quality light-matter interfaces and efficient interconnection with photonic circuitry, this project will (1) develop devices able to perform high-quality programmable nonlinear circuits, and (2) demonstrate how such devices can be used to implement near-term applications, focusing on the quantum simulation of anharmonic molecular dynamics. The developed platform solves a critical set of challenges that have limited the scaling of quantum photonic devices, enabling transformative quantum photonic technologies for quantum computing and networking. The synergy between my strong experience in programmable quantum photonic devices and applications, the world-leading expertise of Prof. Lodahl’s host group in integrated light-matter interactions, and the high interdisciplinarity of the Niels Bohr Institute and University of Copenhagen, makes us uniquely placed to execute this ambitious project.

Keywords: quantum photonics,solid state emitters,quantum simulation,quantum computing
Harnessing the splicing code for targeted control of gene expression (UNLEASH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Germany,United Kingdom
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-06-01
End date: 2029-05-31
Duration (months): 72.0
Total project cost (EUR): 5000764.0
EU funding (EUR): 5000764.0
Participants: 3
Project status: SIGNED

Alternative splicing (AS) of mRNA precursors plays important roles in tissue-specific gene regulation and biological regulatory mechanisms, as it can radically alter protein expression, cell phenotypes and physiological responses. Altered splicing also contributes to disease mechanisms, ranging from neurodegeneration to cancer. Drugs modulating AS have recently provided the first therapy for Spinal Muscular Atrophy, a common genetic disorder, illustrating the huge potential for treating many other diseases of unmet need, if only we understood the mechanisms controlling splice site selection and how to regulate them with small molecules. Unfortunately, despite decades of research, a comprehensive understanding of the mechanisms that control specificity of AS is lacking. This gap in basic knowledge prevents opportunities to harness splicing modulators as tools to study gene function, novel therapeutics or other biotech applications. This Project addresses head-on the major technical challenges that have limited progress in the AS field. Building on extensive preliminary data, we will use a multidisciplinary approach that combines chemical, structural, cellular, systems biology and machine learning to characterize mechanisms of splice site selection and identify targets for modulating these mechanisms using tool compounds. The outcomes will define key regulatory sequences, splicing factors and molecular interactions involved, thereby illuminating how the splicing machinery efficiently accommodates, yet also discriminates between, a wide range of splice site sequences. This will enable future applications harnessing splice site selection. Our primary goal is to answer the central question, ‘Is it generally possible to modulate splicing with high specificity using small molecules?’ Success will transform our basic understanding of human gene expression and unleash major opportunities for Pharma to develop new therapeutics.

Keywords: rna splicing,rna protein interactions
Program Exchange for Chiral Symmetry (EXQIRAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Germany,Italy,Israel,United States
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 1651400.0
EU funding (EUR): 1651400.0
Participants: 5
Project status: SIGNED

EXQIRAL is a proposed 4-year exchange program between the Max Planck Society, ICFO (Barcelona), the Weizmann Institute of Science (Israel), University of Pisa and MIT (USA). The researchers exchange will be based on pre-existing scientific program between these partners and will provide the researchers with a collaborative environment to address fundamental questions in the field of topology, chirality, twistronics or quantum chemistry, amongst others. Many fundamental breakthroughs in science will result from the development of new techniques in this synergetic program: EXQIRAL will develop specialized tools for exploring the chiral nature of matter as well as fabricating novel tuneable devices that take advantage of the unique properties of chiral matter. EXQIRAL will bring tremendous added value not only to the research programs that it will catalyze and incentivize but also in the training and mentoring of young scientists to carry out research that is bold, of high risk, and that will lead to the greatest impact on the scientific world and beyond. EXQIRAL will create a range of structural components that are designed to promote risk taking both in scientific exploration as well as in the translation of research findings to impact on society. A major mission of EXQIRAL will be to foster the careers of the most brilliant young scientists at the participating institutes and, especially, to create structuEXQIRAL is a four-year staff exchange multidisciplinary program between 4 academic partners of four European countries: ICFO (Spain), Weizmann (Israel), Uni Pisa (Italy), MPG (Dresden), and one third-country (MIT, USA). This collaboration is based on an existing program and established collaboration amongst these institutions. The combination of expertise from the five institutes can benefit a joint research program by offering a comprehensive and synergetic approach to studying novel quantum and topological materials and unresolved mysteries like the CISS effect.

Keywords: chiral matter,topology,twistronics,stm,ciss,researchers exchange
Ontologies of Waste: A Relational Study of How Waste Comes to Matter for Humans, Society, and Future (WasteMatters)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1974800.0
EU funding (EUR): 1974800.0
Participants: 1
Project status: SIGNED

The future world imagined by the circular economic model is a world without waste, provided that materials and energy circulate efficiently enough through society. The project WasteMatters disrupts the waste-as-resource paradigm prevalent in the circular economy related politics, business, and scholarship alike, and examines our contemporary trashscapes beyond the idea(l) of the eternal redemption of waste. Its novel approach is to analyse the leaky realities of waste as integral to the human condition and as constitutive of society. The project explores the implications of waste throughout society and what waste does for/to us; what kind of relations, agencies, and spatiotemporal scales it assumes, prompts, enacts, and sustains; to what kind of futures society commits itself with it; and what humans become with waste. The project develops a new methodology, more-than-human ethnography, to be able to attend to the vibrant nature and active role of waste in how we live together. The research will be carried out through four sub-studies across various sites (in Sweden and Finland), which function as important nodal points in the management and circulation of wastes: households, businesses, biogas plants, waste incinerators, and a nuclear waste repository and, to attend to the multiplicity of waste, the project will focus on four kinds of waste: food waste, plastic waste, waste incineration ash, and nuclear waste. Through the research design, the project will generate ground-breaking insight into waste as both constitutive of society and as something that disturbs it. The empirical, methodological, and conceptual insights will be combined to enable a leap in theory building to develop a new relational theory of waste that pays attention to the multiple spatiotemporal scales of society and human actions, ultimately leading to a paradigm change from the circular economy to waste matter society.

Keywords: broken world thinking circular economy ethnography new materialism scale social theory waste