Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Base metal-catalytic cross-coupling methodologies towards sustainability (NextBase)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Austria,France,Germany,Belgium,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 1818798.17
EU funding (EUR): 1595059.2
Participants: 10
Project status: SIGNED

Catalysis is today exploited for preparing ca. 90% of chemical and pharmaceutical products. Use of catalysts allows for efficient chemical transformations, limiting the energy consumption and improving selectivity and atom economy. However, a large number of catalytic systems rely on noble metals (e.g., Pd, Pt, Rh, Ir, Au), with associated sustainability and toxicity issues. Indeed, all these metals are undergoing strong price fluctuations and will face supply limitations in the future. Moreover, given the toxicity of most precious metals, the tolerated threshold in fine chemicals and APIs is very low, with associated purification costs (solvents, energy, generation of waste). For these reasons, replacement of noble metals with the cheaper and generally less toxic 1st row transition metals (TMs) - such as Mn, Fe, Co, Ni, Cu - is becoming a compelling goal for chemists, as well as a need for society. However, this goal also represents a tremendous challenge, as the typical reactivity of 2nd and 3rd row TMs cannot be easily transferred to 1st row TMs, due to their different electronic structure: the so-called "base metals" tend to form high spin complexes and to engage in single electron transfer rather than in the multielectron redox steps typical of noble metals. NextBase is an intersectoral consortium of research groups with a strong expertise in catalysis, who will join forces to take the challenge of noble metal replacement in cross-coupling reactions - a class of transformations of high industrial importance for the production of fine chemicals and APIs. Synergies and complementary types of expertise within the DN will be exploited (i) to harness the reactivity of 1st row TM for several types of cross-coupling, which will be also applied to industrially relevant targets, and (ii) to train PhD students aware of the importance of sustainability issues and expert in the use and combination of sustainable catalytic methodologies.

Keywords: base metal catalysis homogeneous catalysis synthesis of fine chemicals synthesis of apis cross coupling 3d metals
Fast tracking the conversion of dual fuel engines in existing offshore vessels to ammonia operation (Apollo)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Finland,Norway,Greece,Sweden,Bulgaria,Belgium
Call: Transformation of the existing fleet towards greener operations through retrofitting (ZEWT Partnership) (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2027-07-31
Duration (months): 55.0
Total project cost (EUR): 7314447.98
EU funding (EUR): 4999999.25
Participants: 12
Project status: SIGNED

The Apollo project will mature and demonstrate in operational environment, the disruptive installation of a dual fuel ammonia engine in an offshore supply vessel to ammonia operation reducing emissions by 70%. The project is developed to closely answer the HORIZON-CL5-2022-D5-01-04 topic of transformation of the existing fleet towards greener operations through retrofitting (ZEWT Partnership). The specific objectives include: 1) Successful large-scale demonstration of the use of dual-fuel ICE (ammonia-based) in an existing vessel; 2) Complete first classification under DNV “Gas fuelled, Ammonia”; 3) 70% reduction of CO2 emissions and NOx emissions below 2.4 g/kWh from vessel operations; 4) Complete retrofitting solution to operate on ammonia, through development of safe ammonia storage and operation, including both deck load or below deck tanks; 5) Demonstrate the retrofit in replicators in other two vessels with different use (dredging and offshore construction) and validate feasibility for scaling; 6) Support to the expansion of the ammonia bunkering network in the North Sea and beyond, obtain 100% green ammonia for the project’s needs; 7) Validated business case for ammonia as a ship fuel with operational expenditures <130% from baseline by project end. The Apollo solution will be flexible, so ship owners, ship designers, shipyards, classification agencies and insurance companies can quickly adopt it into their decision-making processes. The consortium will prepare the business case for ammonia in the waterborne transport sector, from the production of green ammonia to its use in different ships on the European scale.

Keywords: carbon free fuels,ammonia based engines,ammonia combustion engine,maritime engineering
CATALYSIS IN AQUEOUS SOLUTION BY MAGNETIC INDUCTION: BIOMASS VALORIZATION (BIOCATMAG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

Within a worldwide upsurge of renewable energies and the need to replace chemicals from fossil sources, BIOCATMAG intends to offer a new catalytic approach for producing chemicals from biomass. Based on magnetically induced catalysis, where a catalyst with a magnetic response combines heating and catalytic functions under an alternate magnetic field, the technology presented would enable the coupling of intermittent renewable energies with biomass valorization. Remarkably, several challenges, but also opportunities, lie on the horizon owing to the use of magnetocatalysis. Some of them would be tuning the selectivity by changing the magnetic field amplitude, stabilizing magnetic metal nanoparticles in water or the need to accomplish cascade-type processes. Therefore, the project aims to broaden current knowledge of magnetically induced catalysis while providing a set of chemicals using unprecedented non-noble metal catalysts and greener reaction conditions, such as aqueous media and low pressures. Furthermore, the reactions have been carefully chosen to cover the main areas of interest in biomass valorization by heterogeneous catalysis. In that sense, the transformation of a next-generation platform molecule (levoglucosenone), the production of organonitrogen chemicals (pyrazines), and the valorization of cellulose will be the processes selected. This selection also considers the need to meet the challenges mentioned earlier. In that line, all reactions will be performed in aqueous media, the levoglucosenone hydrogenation or hydrogenolysis will be adjusted with the field amplitude, and, for the valorization of cellulose, a two-step one-pot process to 2,5-bis-hydroxymethylfurane is proposed. In this last case, a multicatalytic batch reactor working with two different temperature regions is proposed for the first time, taking advantage of the differential heating experimented by different metallic materials under the same alternate magnetic field exposure.

Keywords: magnetically induced catalysis,magnetic nanoparticles,complex nanoparticles,biomass derivatives,hydrogenation reactions,cellulose depolymerization,pyrazine synthesis,multicatalytic reactor
Combating CRYPTO-currency-Facilitated Crime and Terrorism with Interoperable, Trustworty, AI-Enhanced, Collaborative Tools, Improved Information Sharing, Operations, and Training for LEAS (CRYPTOACTION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Luxembourg,Greece,Cyprus,France,Finland,Moldova, Republic of,Switzerland,Germany
Call: Tracing of cryptocurrencies transactions related to criminal purposes (HORIZON-CL3-2024-FCT-01, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 6744312.5
EU funding (EUR): 5424031.25
Participants: 18
Project status: SIGNED

CryptoACTION represents Europe’s most ambitious attempt to date in equipping LEAs with mission-appropriate tools to support investigations pertaining to Cryptocurrency-Facilitated Crime and Terrorism (CFCT) activities (money laundering, darknet marketplaces) improve investigation operations including external collaboration workflows and provide comprehensive training curricula for LEAs/prosecutors/judiciary and the world’s first cryptorange. It will deliver an ecosystem of independent but interoperable lawful-investigation tools offering AI co-piloting capabilities to enhance investigator efficiency and supporting the intelligent corelation of blockchain data, structured data from anti-CFCT databases, text, audio and visual data modalities, stemming from lawful surveillance activities and darknet/deepnet/clearnet scraping. It will address technologies/mechanisms that hinder LEA investigations into CFCT, such as TOR, mixers, DEXs, Monero and other privacy coins, etc. both head on and laterally, taking advantage of weaknesses in design/implementation vulnerabilities or human errors on the side of criminals and lawful multi-modal intelligence gathering provided by the tools it will develop and/or enhance. Consortium LEAs will co-design and help validate the CryptoACTION LEA tools and support additional LEA engagement via organising collaborative capacity building workshops based on CryptoACTION training courses and tools. CryptoACTION will take a holistic view of the CFCT landscape and the anti-CFCT efforts, both at the beginning, to guide project efforts, and upon its conclusion, to provide recommendations for further actions, including potential recommendation for regulation and for moving away from cryptocurrency analysis tools giving black-box results to tools, such as those CryptoACTION will deliver, that offer explanations for their results (including any assumptions and uncertainties) and embrace the 7 EU principles of trustworthy AI.

Keywords: cryptocurrency facilitated crime and terrorism
Developing of an solid-state double-layer thermoelectric battery for efficiently powering micro-aerial vehicle (TEnergy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Micro Aerial Vehicles (MAVs) represent a multifaceted technology with utility across a broad spectrum of industries. However, their constrained operational time, primarily due to energy limitations, poses a formidable obstacle. Attempts to bolster energy storage capacity through advancements such as batteries and fuel cells have hit snags in practical implementation. An innovative workaround is the deployment of thermoelectric conversion, capable of capturing and utilizing waste heat and solar energy, yet this avenue is currently hampered by the limitations of available materials. Ionic Thermogalvanic Cells have emerged as a beacon of hope, thanks to their superior Seebeck coefficients, but their incorporation into MAVs necessitates materials of high thermoelectric efficacy and tailored compatibility. The TEnergy initiative is geared towards augmenting the thermoelectric capabilities of ionic thermoelectric materials and refining device architecture for optimized energy conversion. The conceptualization of the double-layer thermoelectric-concentration battery marks a groundbreaking fusion of thermoelectric and battery technologies, promising elevated open-circuit voltage and conversion efficiency. The crux of the TEnergy research lies in its potential to engineer an ultra-compact, highly efficient passive power source for MAVs, harnessing waste and environmental thermal energies. Additionally, the TEnergy endeavor is set on achieving quantifiable milestones, including an open-circuit voltage surpassing 0.25 V for the fundamental unit, a consistent open-circuit voltage of 12 volts and an output power of 100 mW for the amalgamated system, alongside a thermoelectric conversion efficiency rating above 5%. Supported by the MSCA Fellowships, I am committed to pursuing this ambitious research program and the TEnergy research is expected to drive advancements in thermoelectric technology, contributing to the development of sustainable and efficient energy systems for MAVs.

Keywords: ionic thermoelectric,thermogalvanic,heat energy,harvesting,mavs
The first personalized, precision digital therapeutic as a video game for depression (Meliora Next)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: CLOSED

Depression affects more than 280 million people worldwide, about 5% of adults, and remains the leading cause of disability across all disease categories. It contributes globally over 50 million disability-adjusted life years annually with an economic burden exceeding €1 trillion per year, mainly from productivity losses and premature mortality. Current depression treatments yield modest and inconsistent outcomes: only around 22% of patients respond to treatment-as-usual. Existing treatment modalities, such as pharmacotherapy or psychotherapy, focus on mood symptoms and neglect persistent neurocognitive impairments—spanning attention, working memory, executive functions, and cognitive control and flexibility—that sustain functional disability and predict poor recovery. Soihtu DTx has developed Meliora Next, a dual-action precision digital therapeutic combining Executive Function Training with Cognitive Behavioral Therapy to treat the neurocognitive and emotional dysfunctions underlying major depressive disorder. The digital therapeutic has been validated in a large-scale clinical trial with 1,001 patients, demonstrating 3x improvement over treatment-as-usual. Soihtu DTx aims to become the global leader in game-based precision digital therapeutics for mood disorders. Our ambition is to redefine how depression is treated—moving from generic symptom management to personalized, precision digital medicine that integrates with standard care and scales to millions of patients worldwide.

Keywords: mental health,depression treatment,game based treatment,executive functions training,cognitive behavioral therapy,neuroscience
Federated virtual twins for privacy-preserving personalised outcome prediction of type 2 diabetes treatment (dAIbetes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Germany,United States,Romania,Austria,Italy,Sweden,Hungary
Call: Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 8938145.0
EU funding (EUR): 8938145.0
Participants: 13
Project status: SIGNED

Virtual twins may be used as prognostic tools in precision medicine for personalised disease management. However, their training is a data hungry endeavour requiring big data to be integrated across diverse sources, which in turn is hampered by privacy legislation such as the General Data Protection Regulation. Privacy-enhancing computational techniques, like federated learning, have recently emerged and hold the promise of enabling the effective use of big data while safeguarding sensitive patient information. In dAIbetes, we build on this technology to develop a federated health data platform for clinical application of the first internationally trained federated virtual twin models. Our primary medical objective is personalised prediction of treatment outcomes in type 2 diabetes, which afflicts 1 in 10 adults worldwide and causes annual expenditures of ca. 893 billion EUR. While healthcare providers are becoming increasingly effective at targeting diabetes risk factors (e.g. diet or exercises), no guidelines as to the expected outcome for a given treatment for a specific patient exist. To address this urgent, yet unmet need, the federated dAIbetes technology will harmonise existing data of ca. 800,000 type 2 diabetes patients of 4 cohorts distributed across the globe, and learn prognostic virtual twin models. Those will be validated for their clinical relevance and applied in clinical practice through a dedicated software. We aim to demonstrate that our personalised predictions have a prediction error that is at least 10% lower than that of population average-based models. This federated virtual twin technology will enable personalised disease management and act as a blueprint for other complex diseases. Our consortium combines expertise in artificial intelligence, software development, privacy protection, cyber security, and diabetes and its treatment. Ultimately, we aim to resolve the antagonism of privacy and big data in cross-national diabetes research.

Keywords: federated virtual twins,artificial intelligence,type 2 diabetes
REcovering Metals and Mineral FRAction from steelmaking residues (ReMFra)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Italy,Belgium,Austria,Germany,Netherlands,Spain
Call: Improvement of the yield of the iron and steel making (Clean Steel Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 6762123.75
EU funding (EUR): 4645639.0
Participants: 12
Project status: SIGNED

Each year the EU steel sector generates several million tons of metal and mineral containing residues that are currently largely under-exploited and are often sent to landfills with an enormous waste of resources that could replace virgin materials. ReMFra main objective is the development and validation of highly efficient pyrometallurgic melting and reduction demonstration plant at relevant industrial scale for recovering metals and minerals contained in a wide range of steelmaking residues. The ReMFra process will allow to valorise steelmaking residues, such as filter dust, scale, sludge and slags, to obtain pig iron, iron rich oxides, a highly concentrated zinc oxide and an inert slag. ReMFra comprises two main parts to be developed, improved and tested at industrial scale: Plasma Reactor and RecoDust. The first will be dedicated to recover the coarse residues (scale, sludge, slag), while the second will focus on fine-grained dusts. The project will allow the improvement of iron yield using recovered pig iron instead of new pig iron and replacing the iron ore with the iron rich oxide. The recovery of concentrated ZnO and inert slag as by-products will provide a significant source of income and will contribute to the overall carbon neutrality. To reach the full circularity, the process foresees the use, as reducing agent, of secondary carbon sources (i.e. waste plastics). Energy recovery solutions will also be integrated in the metal recovery process starting from enabling the use of molten pig iron. ReMFra consortium comprises: 5 steelmaking companies, 4 RTOs as technology providers with large experience in steel sector, 1 university and the European Steel Technology Platform. To conclude, ReMFra is expected not only to enable technological advances in the demonstrators involved but will also contribute to the development of new standards, training programmes, adaptation and certification of industrial processes thus facilitating the replication of the project.

Keywords: steel,residues,yield,metal and mineral recovery,co2 emissions reduction,certification,replicability
Roles and mechanisms of helper NLR phosphorylation in plant immunity (NRG1 phosphorylation)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Plant diseases caused by microbes result in considerable yield losses in agricultural production systems worldwide, thereby endangering food security. To combat invading microbes, plants have evolved a two-layered innate immune detection system: cell-surface receptor-initiated pattern-triggered immunity (PTI) and intracellular nucleotide-binding leucine-rich repeat receptor (NLR)-initiated effector-triggered immunity (ETI). Interestingly, cell-surface receptors are required for full NLR-mediated plant immunity. NLRs are classified as sensor NLRs, involved in effector detection, or helper NLRs, required for sensor NLR signalling. Our preliminary data demonstrate that in Arabidopsis thaliana the helper NLR N REQUIREMENT GENE 1 (NRG1) undergoes PTI-dependent phosphorylation, which plays an important role in NRG1-mediated programmed cell death. This suggests that helper NLR phosphorylation may be a crucial checkpoint for PTI/ETI mutual potentiation. This project aims to unravel the molecular mechanisms by which NRG1 is phosphorylated and how its phosphorylation potentiates NLR-initiated immune signalling. My host institute, the Sainsbury Laboratory (TSL), has all the resources to carry out this research. During my work supported by this fellowship, I will be trained in molecular biology, biochemistry, genetics, proteomics and bioinformatics, which will lay the foundation for my future career as an independent researcher. In turn, I will bring my specific expertise in phosphorylation-based activation of cell-surface receptor complexes in Nicotiana benthamiana and tomato, which is not currently available in my host lab. The findings of this project will advance the understanding of plant-microbe interactions and should provide new strategies for crop protection and plant breeding. Furthermore, I will be equipped with the skills and experience necessary to position myself as a leading independent researcher.

Keywords: plant innate immunity pattern triggered immunity pti effector triggered immunity eti nucleotide binding,leucine rich repeat receptors nlrs phosphorylation