Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On the evolution of fleshy fruits: An integrative test to assess the relative role of intrinsic and extrinsic factors in shaping fruit type (FRUITFUL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2022-09-20
Duration (months): 36.0
Total project cost (EUR): 295061.76
EU funding (EUR): 295061.76
Participants: 1
Project status: CLOSED

A trip to a grocery store exposes us to an outstanding diversity of fruits. While this variety was influenced by human selection during plant domestication, it mainly reflects strategies of seed dispersal that evolved over millions of years. Despite the huge variation in fruit color, shape, and size, common patterns can still be identified, especially the repeated evolution of fleshy fruits (e.g. olives, apples, tomatoes). Though this pattern is well observed, we are still exploring the role of different factors and their selective pressures. These can be intrinsic, as evolution of inherited genes determining fruit traits, or extrinsic, as the environment. To date, studies have focused on one or two major factors at a time, but their relative contributions requires an integrative analysis. FRUITFUL will dissect the evolution of fleshy fruits in the olive family. Oleaceae is the ideal study subject here because it presents a natural comparative set-up for fruit evolution: multiple lineages that independently evolved fleshy fruits; species living in a variety of environments; and diverse seed dispersers. Further, several genomes and transcriptomes of Oleaceae were recently released. In this project, I will: (1) identify independent transitions to fleshy fruit within a comprehensive phylogenetic framework of Oleaceae; (2) use phylogenomic approaches to analyze representative genes in species with fleshy or dry fruits, and test for switches in selective pressures in relation to trait transitions; (3) estimate the historical biogeography of the family, along with current environmental preferences of species, and their seed dispersers; and finally, (4) integrate all results in models of causal relationships, and identify direct and indirect effects, and their magnitudes, among variables and fruit type. FRUITFUL’s interdisciplinary research and novel integrative approach will provide new insights into understanding the patterns observed at a macroevolutionary scale.

Keywords: macro evolution,oleaceae,olive,plant evolution
Communities and Connectivities: Iron Age Britons and their Continental Neighbours (COMMIOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2025-09-30
Duration (months): 72.0
Total project cost (EUR): 3264872.0
EU funding (EUR): 2084315.0
Participants: 6
Project status: SIGNED

Recent breakthroughs in ancient DNA and isotope analysis are transforming our understanding of diversity, mobility and social dynamics in the human past. COMMIOS integrates these cutting-edge methods on a scale not previously attempted, within a ground-breaking interdisciplinary framework, to provide a radically new vision of Iron Age communities in Britain (800 BC – AD 100) within their wider European context. At the broad scale, we will conduct the first concerted programme of genome-wide ancient DNA analysis on Iron Age populations anywhere in the world (c. 1000 individuals in the UK, 250 in Europe), mapping genetic clusters to shed light on ancient populations themselves and on their relationships to modern genetic patterning. Together with isotope analysis, and underpinned by both osteoarchaeological and cultural archaeological approaches, this will also enable us to directly address critical issues of population movement and inter-regional connectivity in Iron Age Europe. We will utilise the power of these new scientific methods to examine the structure and social dynamics of Iron Age societies in Britain, including household and kin-group composition, the identification of familial relationships, gender-specific mobility, and the development of social inequalities. Previously the preserve of cultural anthropologists studying recent societies, we will draw these questions into the archaeological domain, opening up new areas of enquiry for prehistoric societies. The scope and scale of the project represents a new departure for European archaeology, made possible by the coming-of-age of new analytical methods. Many of these have been pioneered by the project team, which comprises world-leaders in the fields of ancient DNA, isotope analysis, osteoarchaeology, chronological modelling and cultural archaeology. Although focussed on Iron Age Britain, the project will establish a new benchmark for future analyses of other regions and periods in Europe and beyond.

Keywords: iron age britain,iron age europe,ancient dna,isotope analysis,osteoarchaeology,social dynamics,funerary archaeology
Targeted strategies for prevention and treatment of fibrosis-associated liver cancer (FIBCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,United States
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 2430000.0
EU funding (EUR): 2125000.0
Participants: 2
Project status: SIGNED

Advanced liver diseases such as cirrhosis and hepatocellular carcinoma (HCC) are major challenges for global health. HCC is the second leading and fastest rising cause of cancer death worldwide. Viral and metabolic liver disease are the main risk factors for HCC, which nearly always arises in advanced liver fibrosis. For metabolic liver disease approved therapies are absent. Cure or suppression of viral infection cannot eliminate the HCC risk in patients with advanced fibrosis. Despite significant progress, therapeutic options for established HCC are still limited in efficacy and safety. Importantly, patient survival in HCC is dependent on the underlying fibrotic liver disease which is not targeted by approved HCC therapies. Addressing these unmet medical needs, FIBCAN aims to identify urgently needed targets for prevention and treatment of fibrosis-driven liver cancer. A key focus of FIBCAN will be the investigation of Claudin-1 as a previously undiscovered target for prevention and treatment of fibrosis-driven HCC. Our own data obtained in patient-derived model systems and tissues provide solid evidence that Claudin-1 is implicated in liver fibrosis and hepatocarcinogenesis, and overall and liver-specific patient death. To discover novel targets, we will apply a liver disease discovery platform modeling the clinical cell circuits of cirrhotic patients progressing to HCC combined with single cell RNA-seq and spatial transcriptomics of patient tissues. Proof-of-concept studies of target-specific compounds combined with biomarker discovery in cutting-edge patient-derived model systems will deliver novel strategies for further clinical development. A strong collaboration with pharma will lead to rapid translation of the FIBCAN program into the clinic. By delivering urgently needed therapeutic strategies for advanced liver disease and HCC, this proposal will have a marked impact on the management and outcome of patients with advanced liver disease in Europe and beyond.

Keywords: liver disease,liver cancer,hepatitis c,hepatocellular carcinoma,cellular pathways,kinases,phosphatases,viral hepatitis,drug target,biomarker,cell circuits
Development of a titanium composite brake part for weight reduction and hence lower fuel burn and emissions on a large, long haul aircraft (TMC Brake)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will develop the technical, business and market analysis required to develop, a viable performance and economic case for Airbus to invest in flight qualification of titanium metal matrix composite (TiMMC) drive bars for large civil airliners such as the Airbus A380. Lower aircraft weight results in reduced fuel consumption and CO2 emissions. These are commercial and regulatory drivers for airlines, hence an industry standard value of €700/kg saved is used as a premium to introduce new technologies. TISICS will demonstrate a novel fibre reinforced TiMMC technology to replace brake parts that are currently steel, due to the high operating temperature and loads. TiMMC matches steel but is 40% lighter equating to 110kg saving on an A380, lower mass savings are possible on other airliners however the annual build quantities are higher. For A380 the annual market is estimated at €3.5M to €4M per year. Airbus will be the primary customer with export sales outside the EU in the future. Introducing a new material technology to safety critical aerospace applications is challenging, especially for an SME, hence the need for an SME instrument programme. We must design, make and test proof of concept parts as well as travel to Airbus and its suppliers to obtain data and support for a phase two project. Phase 1 will engage Airbus to obtain design parameters. We must identify potential industrial processes and composite geometry for parts. TISICS will use the data to evaluate designs through FEA analysis and fabrication and basic test of parts made with different processes to assess manufacturing issues and costs. Phase 2 will develop processing and design to a high TRL to provide sufficient data that Airbus needs to justify investing in full qualification programmes. TISICS must convince Airbus and its brake suppliers that the technology is robust and economic to complete the flight qualification steps, which should be possible within 2 to 3 years of completing Pha

Keywords: titanium composite,metal matrix,aircraft brakes,light weight,co2 reduction,high specific strength,high specific stiffness,high temperature materials,efficient aircraft,near net shape
INdustrial and tertiary product Testing and Application of Standards (INTAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Spain,Italy,Italy,Germany,Belgium,Finland,Romania,Poland,Czechia,United Kingdom,Portugal,Denmark,United Kingdom
Call: Ensuring effective implementation of EU product efficiency legislation (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1906966.25
EU funding (EUR): 1880448.0
Participants: 17
Project status: CLOSED

There is a need to strengthen the capacity of Market Surveillance Authorities (MSAs) to conduct Ecodesign related market surveillance activities with respect to new and pending industrial and tertiary sector products. Especially in the case of customised products which are unsuitable for testing in laboratories. There is a lack of expertise, experience, and resources available across Europe for such kind of testing. An increasing concern is that new regulations addressing these products risk being unenforceable. The aim of the INTAS project is to address these concerns and provide technical and cooperative support, as well as capacity building activities, to MSAs charged with enforcing these regulations. The need for the INTAS project arises from the difficulty that MSAs and market actors face in establishing and verifying compliance with energy performance requirements for large industrial products subject to requirements of the Ecodesign Directive. The focus of the project is to support compliance for very large industrial products, specifically transformers and industrial fans, with the requirements of the Ecodesign Directive. The energy consumption of transformers and industrial fans is very significant and thus the risk of losses due to poor compliance cannot be ignored. The project aims to: a. support European Member State MSAs deliver compliance for large products (specifically for transformers and large fans); b. support industry to be sure of what their obligations are under the Ecodesign Directive and to deliver compliance in a manner that will be broadly accepted by MSAs; c. foster a common European approach to the delivery and verification of compliance for these products. The INTAS project involves 16 partners among them there are 11 organisations, which are National MSAs or cooperating closely with the National MSAs, targeting 10 European countries (Austria, Belgium, Czech Republic, Denmark, Finland, Poland, Portugal, Romania, Spain and Italy).

Keywords: energy efficiency,transformers,fans
Fast Radio-Labeling and Isotope Exchange (FASTLabEx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1999431.0
EU funding (EUR): 1999431.0
Participants: 1
Project status: SIGNED

The impact of synthetic organic molecules on health, life quality and lifestyle is beyond doubt. It is therefore of fundamental importance to detect and quantify the fate of organic compounds and provide a precise risk/benefit assessment, before they reach the market and large public exposure. The traceless incorporation of carbon-14 allows tracking organic molecules and provides vital knowledge on their fate. This information is critical for pharmaceutical development, crop science and human food safety evaluation. Surprisingly, carbon radiolabeling still represents a bottleneck and an unsolved fundamental problem. In fact, current synthetic strategies are marred by several major drawbacks, including the generation of radioactive waste, being multi-step time-consuming and high resource-demanding. To circumvent such disadvantages, I present FASTLabEx, a novel approach for the straightforward preparation of carbon-labeled complex organic molecules that introduces the radioactive tag at the ultimate-stage of the synthesis. Inspired by efficient metal-catalyzed transformations, FASTLabEx makes use of a novel paradigm of “carbon isotope exchange”, defined as the selective replacement of molecular moieties into organic molecules, by reversible molecular deconstruction/reconstruction in presence of an appropriate radiolabeled moiety. FASTLabEx will explore this concept onto a large variety of functional groups and structural diversity, far beyond the case of carboxylic acids. This approach has the potential to streamline the radio-synthesis of pharmaceuticals and agrochemicals. Outcomes from FASTLabEx will have a tangible societal impact not only for the radiochemical community, but also for pharmaceutical and agrochemical industries and in fine the consumers and patients. In order to mitigate the risks inherent to the project, preliminary results demonstrate its feasibility.

Keywords: carbon 14,radiolabeling,isotopic labeling,isotope exchange,carbon dioxide,carbon monoxide
New dimension of fibre optics – bringing 5G to your town with IPT-Core (IPT-Core)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 3075750.0
EU funding (EUR): 2153025.0
Participants: 1
Project status: SIGNED

We are on the verge of 5G arrival, the new standard bringing much higher speeds and more reliable connections to millions of end users and possibly billions of connected IoT devices. 5G networks require many more small sites than other cellular systems, and the industry agrees that their demand for bandwidth can only be met with fixed optical fibre connections. These are not available in many locations, and space in existing cable ducts is limited while accessing them is costly. At the same time, even at the speed of light, current Single-Mode Fibres have reached their theoretical capacity limit. Global IP traffic demand for urban fibre networks is forecast to grow at a blistering CAGR of 45% in the coming years. The problem is that current fibre infrastructure cannot continue to support the foreseen demand without an upgrade to carry the increased traffic beyond its theoretical capacity. However, deploying a completely new infrastructure is costly and therefore, not an option. It is a challenge to meet the growing demand using the existing infrastructure – this requires a new approach. At InPhoTech, we see this “Capacity Crunch” as an opportunity. Our patented IPT-CORE telecommunication technology uses seven cores in every single microstructured fibre as separate spatial channels, allowing the most effective use of our well-developed multiplexing methods to increase optical throughput seven times in the same physical space. By being fully compatible with existing infrastructure, IPT-CORE provides a cost-effective replacement for target customers such as 5G operators, providers of FTTx services, Long Distance Connections and Data Centres. Our ultimate goal is to become the world’s first mass-scale multicore optical fibre supplier, putting the EU at the same level as the US and Asia as global fibre providers. The technology will be held by InPhoTech and will generate a growth impact for the company of €23 million in profit 5 years after deployment.

Keywords: 5g mobile fronthaul,backhaul,data centre,radio access network,multi core,compatible,optic fibre cable,microstructure,capacity crunch,bandwidth demand,digital europe,mass production
Development and Manufacturing of Intelligent Lightweight Composite Aircraft Container (INTELLICONT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Greece,Greece,Greece,Greece,United Kingdom,United Kingdom
Call: SmartContainer (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-11-30
Duration (months): 45.0
Total project cost (EUR): 2506234.75
EU funding (EUR): 1999944.86
Participants: 7
Project status: CLOSED

Air cargo has experienced tremendous growth. Essential components and open field of technological advancement are air-cargo containers (ULDs) which have not followed the technological advances of aircraft structures and systems. The faced challenges are: reduce ULD and aircraft weight; enhance container fire/smoke detection and suppression; eliminate permanent moving and locking hardware; enhance flight safety, loading/unloading logistics and maintenance. The main goal of the proposal is to develop, manufacture and validate a new intelligent lightweight aircraft cargo container with integrated functions for restrain, transportation, fire/smoke suppression, with sensing and wireless monitoring capabilities. The outlined approach entails development of a full composite ULD, manufactured by low cost, high output methods (pultrusion, RTM). Following common certification practice, a building block approach is employed to design and validate the container. A self-moving platform allowing the motion of the ULD inside and outside the aircraft. Low-cost and low-energy sensors in the container track status (ID, location, locking state) and detect critical events, fire/smoke, impacts and accidental misuse. The status of each container will be available to the pilots though a wireless communication network, such that problems would be detected and proper measures would be taken. Lab-scale and full-scale tests are proposed for the validation of the ULD. Obtained numerical and test data will pave the routes to certification and industrialization. The ambition of the project is to provide a major break-through in the state of the art of current ULD technology and aircraft cargo operations. Substantial impact is anticipated on the CleanSky program, the reduction of aircraft payload and weight, safety, maintenance and lean aircraft operation processes. INTELLICONT will be a game changer for the air-cargo industry with substantial broader impact on air-cargo handling operations.

Keywords: smart container,lightweight,composite,fire smoke suppression,self moving and locking,wireless communication and control