Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterizing Function Genetic Variants Linking Immunity and Psychiatric Disorders (IMAGENE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-01
End date: 2020-07-31
Duration (months): 36.0
Total project cost (EUR): 257860.8
EU funding (EUR): 257860.8
Participants: 2
Project status: CLOSED

Understanding genetic risk for disease is one of the major goals in human genetics. Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human diseases, the majority of them locating in regulatory regions outside of genes. The identification of functional regulatory variants underlying such GWAS associations and understanding their pattern of activity is the key for understanding biological processes behind each genetic association to disease – and without such understanding, targeted interventions and drugs to affect the relevant pathways are not possible. IMAGENE will elucidate the role of functional genetic variants that link immunity and psychiatric disorders such as schizophrenia. This will be achieved by combining state-of-the-art technologies in genome engineering, Next-Generation sequencing and computational biology, which will allow obtaining mechanistic insight into genetic risk of human diseases at unprecedented depth. The applicant has unique interdisciplinary skills to carry out the project, including clinical background and basic research experience in the different fields united in this proposal – human genetics, immunology, and psychiatry. The impact of the project could be enormous, since elucidating the molecular mechanisms of disease-associated variants that link immune function to disease pathology of schizophrenia could contribute to the development of novel treatments for this disease.

Keywords: genome wide association studies,eqtl analysis,toll like receptors,human monocytes,schizophrenia,genome engineering,crispr,rna seq
Atomic precision materials engineering (ATMEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1497202.0
EU funding (EUR): 1497202.0
Participants: 1
Project status: CLOSED

Despite more than fifty years of scientific progress since Richard Feynman's 1959 vision for nanotechnology, there is only one way to manipulate individual atoms in materials: scanning tunneling microscopy. Since the late 1980s, its atomically sharp tip has been used to move atoms over clean metal surfaces held at cryogenic temperatures. Scanning transmission electron microscopy, on the other hand, has been able to resolve atoms only more recently by focusing the electron beam with sub-atomic precision. This is especially useful in the two-dimensional form of hexagonally bonded carbon called graphene, which has superb electronic and mechanical properties. Several ways to further engineer those have been proposed, including by doping the structure with substitutional heteroatoms such as boron, nitrogen, phosphorus and silicon. My recent discovery that the scattering of the energetic imaging electrons can cause a silicon impurity to move through the graphene lattice has revealed a potential for atomically precise manipulation using the Ångström-sized electron probe. To develop this into a practical technique, improvements in the description of beam-induced displacements, advances in heteroatom implantation, and a concerted effort towards the automation of manipulations are required. My project tackles these in a multidisciplinary effort combining innovative computational techniques with pioneering experiments in an instrument where a low-energy ion implantation chamber is directly connected to an advanced electron microscope. To demonstrate the power of the method, I will prototype an atomic memory with an unprecedented memory density, and create heteroatom quantum corrals optimized for their plasmonic properties. The capability for atom-scale engineering of covalent materials opens a new vista for nanotechnology, pushing back the boundaries of the possible and allowing a plethora of materials science questions to be studied at the ultimate level of control.

Keywords: graphene,scanning transmission electron microscopy,first principles modeling
New Material Hybrids With Helical Inner Architecture: Fundamentals And Technology (HybridMat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 170509.2
EU funding (EUR): 170509.2
Participants: 1
Project status: CLOSED

A new approach to design and manufacture hybrid materials based on biomimetic principles is proposed. The internal structure of multi-component metal hybrids will be created simultaneously at two levels: nanostructuring each constituent while also architecturing helical macroscale features. This project aims on fundamental study of physical mechanisms triggered by simultaneous mixing and nanostructuring of immiscible metals by severe shear while producing new types of hybrid materials. Severe Plastic Deformation (SPD) with rotating shear plane and variable inclination angle will be used for production of multicomponent materials to obtain properties not found in individual conventional materials. This will be achieved by ‘architecturing’ the inner structure of the hybrid with consideration of the interface bond and enhanced inter-diffusion under SPD. A model of a hybrid consisting of different constituents with intercalated boundary layers will be developed. A thrust of research is primarily directed at the barely investigated shape and length scale effects of the constituents on the resulting properties of the new material. For practical applications, it addresses the nanostructured high-strength electrical conductor cables for efficient energy transmission. The project assists in developing novel manufacturing technologies for niche applications.

Keywords: hybrid materials,biomimetic,nanostructuring,metal hybrids
Sustainable polymers application for preventive maintenance and upgrading of resilient and secure roads (SPA4ROADS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The impact of the current economic crisis on investment in construction of new roads has been acute, and this negative impact has also been the reality for maintenance budgets. This situation, stagnant for the last four years, has led us to a point where the deterioration of the roads we transit is appreciable. The focus of maintenance expenditure in Europe is now shifting towards road infrastructure preservation. Helopav’s SPA4ROADS project offers an innovative solution for road maintenance, providing an efficient treatment method at a reduced cost based on new surfacing materials (polyurea). The solution consists of 1) a preevaluation of the road, 2) definition of the application methodology and 3) the application of the polyurea through a specific machine. The effect of the solution is twofold, as it preserves the road from deterioration and also enhances its properties, significantly reducing maintenance costs. Thus, the main objective the SPA4ROADS project is to improve the lifespan and security of roads in urban environments, in turn minimizing emissions of CO2 from application and VOCs, and also reducing vehicle braking distance. SPA4ROADS will compete in public bidding projects for road maintenance projects, targeting segments of urban roads that are particularly susceptible to erosion from traffic (e.g. roundabouts, cross-sections). Spain, Italy and Germany will be targeted initially due to Helopav’s previous experience dwelling in these markets, with a gradual expansion into further European markets. New jobs and increased revenue will greatly increase Helopav’s market positioning. Presenting a strategic solution in comparison to its competitors, SPA4ROADS has the potential to greatly improve the safety, economics and environmental performance of Europe’s urban roads, and participation of Helopav in the SME Instrument phase 1 will provide the company with the tools catalyse this innovation at the European level.

Keywords: road maintenance expenditure,polyureas,road surfacing,road safety,environmental performance,deterioration prevention,road lifespan,urban roads,market introduction,application method
Xene Fabrication for a Two-Dimensional Nanotechnology Platform (XFab)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1998785.0
EU funding (EUR): 1998785.0
Participants: 1
Project status: SIGNED

Xenes denote two-dimensional (2D) monoelemental (X) crystals beyond graphene with a honeycomb lattice. Unlike graphene, Xenes do not exist in Nature, but they become stable via epitaxy on substrates. So far experimental evidences of Xene epitaxy have been reported for X=Si, Ge, Sn, B, P, and Sb (named silicene, germanene, stanene, borophene, phosphorene, and antimonene, respectively). Xene single layers also serve as a background for the synthesis of new Xene-related materials (XRMs) such as Xene heterostructures and functionalized Xenes. Xenes can appear as metals, semimetals, semiconductors, and topological insulators thus allowing for a broad range of applications in nanotechnology. However only silicene has been integrated into transistors operating at room temperature albeit fast degradation. Nonetheless, a viable Xene-based nanotechnology is currently missing due to the lack of reliable standards for the Xene production and implementation. For this purpose, the proposal aims at developing viable schemes for high-quality crystal growth, environmental stabilization, and device integration of Xenes and XRMs frameworks. At first the effort will be focused on the high-quality synthesis of selected Xenes and XRMs by means of molecular beam epitaxy, and on their stabilization in encapsulated structures enabling subsequent processing into Xene-based device platforms. Validation of the Xene properties, quality, and performances will be carried out by means of advanced in situ and ex situ characterization of the atomic and electronic structure. Secondly, prototypical electronic device (e.g. field effect transistors or vertical diodes) incorporating stabilized Xene frameworks as active elements will be used to assess the Xene electrical behaviour and performances so as to establish a reliable Xene-based nanotechnology.
Development of hypothalamic circuits for the control of homeostasis (ONTOGENY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999973.0
EU funding (EUR): 1999973.0
Participants: 1
Project status: CLOSED

Obesity is a significant global burden that is associated with adverse health outcomes. Adults are not alone in their struggles with obesity. Children now accumulate fat at an alarming rate, making childhood obesity a major health problem. Unfortunately, we do not know enough about the pathophysiology of these conditions to propose appropriate prevention strategies and more effective therapeutic approaches. In this ERC StG proposal, our goal is to discover the developmental processes important for proper con-trol of energy homeostasis. We will study Agrp and POMC neurons, located in the arcuate nucleus of the hypothalamus, that are heavily involved with control of energy homeostasis. Agrp and POMC neu-rons have delayed postnatal development, maturing their axonal projections around the third postnatal week in rodents. Here, we will study in detail this late ontogeny of Agrp and POMC neurons. In Aim 1, we will use novel approaches to measure Agrp and POMC neuronal activity during mouse development in response to nutrients and hormones involved in energy homeostasis. In Aim 2, we will use whole-brain imaging techniques to determine the anatomical development of Agrp and POMC neuronal projec-tions. We will also study the importance of a specific neuronal circuit in neonates to the development of obesity. Finally, in Aim 3, we will identify critical molecular mechanisms involved in the ontogeny of Agrp and POMC neurons by investigating their translatome over the course of postnatal development. Overall, this project will provide novel insights into Agrp and POMC neuron development in conditions relevant to childhood obesity and metabolic dysregulation. The functional, anatomical and molecular mechanisms illuminated here will provide the foundation for future studies aimed to dissect the devel-opment of other homeostatic systems.

Keywords: hypothalamus,metabolism,neuronal circuits,development
inveSTigation of an ultrA compact Reverse flow combusTor (START)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy
Call: Advanced investigation of ultra compact RQL reverse flow combustor (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-02-01
End date: 2021-03-31
Duration (months): 38.0
Total project cost (EUR): 640867.5
EU funding (EUR): 640867.5
Participants: 2
Project status: CLOSED

The main objective of START project is to carry out a series of advanced investigations on a prototypical reverse flow, ultra compact, combustor designed and manufactured by GE-Avio for turboprop engine as a part of the SAT ITD MAESTRO. The aim is to support the validation of the developed technologies and design rules by means of full annular combustion tests and high fidelity numerical simulations. Goals of START project will be addressed with the following steps: Verify a full additive combustor at real engine conditions in terms of combustor performance, by the measurement of emissions, gas exit temperature and liner metal temperature, through extensive full annular tests. Data will also permit validation of numerical modelling results. Improve the knowledge of combustor metal temperature and validation of aero-thermal predictions by gathering 2D temperature maps using InfraRed techniques across dedicated optical access on the full annular rig. Improve and further validate existent aero-thermal CFD modelling based on a two-step approach: RANS based CHT calculations for metal temperature and flow split predictions and LES (or Hybrid RANS-LES) calculations of the flame domain for combustor performance evaluation. Development of an innovative CFD approach based on unsteady CHT based on Hybrid RANS-LES, to allow direct calculation of aero-thermal and combustion performance behavior of the combustor. The methodology will also exploit and further validate dedicated strategy to model multi-hole liners without requiring the explicit meshing of each hole. START will greatly contribute to the goals of SAT initiative in CS2. The validation of innovative high fidelity CFD will significantly help the design of innovative combustors for addressing the target of SFC reduction faced with the increase of engine cycle efficiency. The validation of innovative additive manufacturing components at TRL5 will positively contribute to reach the objectives of reducing costs and weights.

Keywords: full annular test,rans,infrared,additive manufacturing
Disruptive tracer technology based on synthetic DNA to map subterranean resources (WELLGENETICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Well Genetics was founded in 2012 in Norway by a joint team of pioneers in the use of DNA as industrial tracer and specialists with over 25 year’s track of record in monitoring of underground reservoirs. Well Genetics’ DNA tracers are composed of synthetic DNA sequences encapsulated within polymer coatings. These tracers travel along underground reservoirs and fractures and enable operators to map subsurface water and oil flows. With our tracers, we mimic nature’s craftiness to store information. We can deliver billions of unique DNA tracer combinations with a detection limit that is thousands of times less than for currently used tracers, at a 50% cost reduction of an average tracer job. Given that in underground environments, information is key to trigger millionaire investments, our DNA tracers represent a strategic value for the exploration and production of oil and geothermal energy industries, with potential benefits for our customers in the million euros range. Moreover, we contribute to the sustainability of the energy mix. The understanding of underground flows enables more sustainable oil extraction avoiding additional wells and, makes renewable geothermal energy production feasible in locations other than limited volcanic areas. In fact, the future of geothermal energy lies in take advantage of the heat stored in the subterranean rock layers of the Earth, the information conveyed by our DNA tracers critical to tap into this clean, cheap, constant and abundant renewable energy source. Third parties have tested the DNA tracers to ensure they are resilient enough to withstand high temperatures and conditions of reservoirs and we have received high interest from the industry. Now, successful commercialization requires demonstrated field results. Through the feasibility study phase, we will establish the conditions of the first field trial, that will trigger sales of the product.

Keywords: tracer,biochemistry,geothermal energy,sustainibility,oilandgas
Non-Invasive, Private and Ultra-Low Cost 24/7 Health Care Monitoring for the Elderly Community (HomeSafe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HomeSafe will conduct a feasibility study for the development of a Non-Invasive, Private and Ultra-Low Cost 24/7 Health Care Monitoring System for the Elderly Community based on Ultra-Wide Band Sensing. In few words, advances in radar-based sensing are enabling disruptive applications in various sectors. In HomeSafe, one such sensor can be placed in a home to monitor the status and conditions of persons within it for the cost of one Euro per day. The approach to use just one sensor and at such a low cost is radically different than competing alternatives. This sensing capability is integrated into a cloud-based health care monitoring and alert system. No images are attained and nothing is worn by individuals assuring dignity, privacy and use with confidence. With respect to competing systems (push button alerts, sensorised individuals or homes), the advantages are compelling and there is a clear innovation potential for future IP development that tracks a person's condition state over time and conducts data fusion (combining a person’s gait, heartbeat, breathing patterns, reactions to events or medication to see cause and effect relationships or response to treatment). Commercialisation potential is also clear since stakeholder wishes, value proposition, viable business models have been defined as well as progressive multi-stage market uptake over time is envisioned. The workplan is structured to reduce technical, market and ethical and regulatory risks associated with a product launch and immediate EU expansion via distributor networks. The feasibility study will provide us with the opportunity to engage targeted stakeholders across Europe, deepen our market knowledge and assure our value proposition fit. Pisga is perfectly positioned to develop, commercialise and internationally scale the HomeSafe product and service. It has already secured an exclusive contractual alliance with the patent holder to foster its ambitions.Ten-fold growth projections are envisioned.

Keywords: ultra wideband sensing,fall and gait detection,privacy aware monitoring,first mover disruptive,technology,home monitoring,home care,personal emergency response systems