Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Europe's Moment: Designing Effective Policies in Energy Storage Technology for Renewables (RE-DESIGN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-09-01
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

The Paris Agreement is the first international accord to engage with the full-scale investment efforts required to address climate change. Moreover, the Sustainable Development Goals (SDGs) have emerged as the global benchmark for directing investments to the clean energy sector. And yet, neither scholarship nor practice has illuminated the combined implications of the Paris Agreement and SDGs for determining how businesses can evolve to maintain their competitiveness and fuel the energy transitions to a net-zero emissions society by the second half of the century (Article 4(1) of the Paris Agreement). In this context, the European Union (EU) starts from a vantage point, which is an ambitious internal action plan toward decarbonization (e.g. the European Green Deal (EGD)), but policy design fails to combine Europe's external and internal obligations to support decarbonization technology. This project focuses on one of the most important areas for decarbonization policies, Energy Storage Technology (EST) for renewable energy, to propose a refined regulatory framework to fulfill the EU's external and internal commitments in climate policy. The project investigates how sustainable investment in renewable energy storage can be fostered through effective policy design that includes prosumers (energy-producing consumers), starting in the EU. Empowering and coordinating prosumers and businesses through effective policy design is one of the most promising strategies for the EU to achieve its vision of a citizen-oriented energy future and 100% renewable energy system by 2050. The multidisciplinary nature of the project is strong, involving policy design, EU and international law and sustainable finance. It includes a two-way transfer of knowledge and the training of the candidate in advanced techniques in energy and climate economics. In line with the EGD, the proposed policy is poised to increase EU competitiveness in EST for renewable energy, and results are transferrable.

Keywords: decarbonization,energystoragetechnology,renewable energy,sustainablefinance,openinnovation,lawandpolicy,greennewdeal,euclimatelaw,parisagreement,sdgs
Heavy Ion Therapy Research Integration plus (HITRIplus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Italy,Austria,Germany,Italy,Malta,Switzerland,Sweden,Switzerland,Hungary,Slovenia,Latvia,France
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-04-01
End date: 2025-09-30
Duration (months): 54.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 5000000.0
Participants: 19
Project status: SIGNED

The goal of Heavy Ion Therapy Research Integration plus (HITRIplus) is to integrate and propel biophysics and medical research on cancer treatment with heavy ions beams while jointly developing its sophisticated instruments. Cancer is a central health problem for our society. Heavy ion beams irradiate tumours by focussing on the ill tissue while sparing the healthy part around, more effectively than any other irradiation treatment. The wider objective of HITRIplus is to provide radiation oncologists with a cutting-edge tool to treat the fraction of tumours that are not curable with X-rays or protons or have better survival rates or lower recurrences with ions. For this major initiative, HITRIplus has gathered a consortium engaging all relevant stakeholders and for the first time bringing together all four European ion therapy centres with leading EU industries, academia, and research laboratories. They all share the ambition to jointly build a strong pan-European Heavy Ion Therapy Research Community. A strategic partner is the South East European International Institute for Sustainable Technologies, which federates eight countries in South East Europe with the ambition to build a next generation heavy ion Research Infrastructure in the area, to boost research and cooperation in a region trying to rebuild after a troubled past. HITRIplus Transnational Access will integrate and open to external researchers the experimental programme of the five European facilities providing therapeutic ion beams. Its Networks will structure and foster the research on heavy ion therapy, including clinical and pre-clinical research. Joint Research Activities will develop new accelerator and beam delivery technologies to extend the reach of the present generation centres and to define a new European reference design, at lower cost and dimensions, to make cancer ion therapy more accessible and to open new markets to European industry.

Keywords: heavy ion beams,biophysics and radiobiology,clinical research,new accelerator technology,advanced beam delivery technology,integrated research,superconducting gantry,superconducting synchrotron
Shaping Body Movements through Interactions with Brainstem Neurons (InterAct)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 2427500.0
EU funding (EUR): 2427500.0
Participants: 1
Project status: SIGNED

Understanding how neuronal circuits regulate the enormous repertoire of movements is a key outstanding question in neuroscience. Neurons contributing to execution and learning of body movements are distributed throughout the nervous system. Control of body movements entails the engagement of connected brain motor centers to generate action commands, providing instructions for execution to the spinal cord. The brainstem as focus of this proposal represents an essential intermediary between upper planning and spinal executive motor circuits. Recent technological advances have led to the identification of brainstem neurons regulating diverse forms of body movement, including locomotion and skilled forelimb movements, both engaging limbs but for very distinct purposes. The goal of this project is to understand how brainstem populations involved in specific body movements are endowed with their behavior-specific fingerprints through interactions within the broader motor system. We aim to determine how key synaptic inputs to specific brainstem neurons shape their activity patterns in synchrony with the regulated behavior. We hypothesize that the emergence of action-specific neuronal ensembles in the brainstem requires control by their driver, gating and modulatory elements, with the function to promote the recruitment of specific brainstem neurons during desired actions and to suppress them when no or alternative actions are planned. We build on our know-how on brainstem neurons and use sophisticated combinatorial viral-genetic targeting strategies, state of the art neuronal recording and activity-pattern modifying technologies, combined with precise quantitative behavioral readouts in mice to address this question. Together, our project will elucidate circuit mechanisms by which brainstem neurons interact in the motor system to control the generation of body movements, thereby uncovering principles of how the nervous system generates diverse actions.

Keywords: motor system,neuronal control of movement,neuronal circuits and populations,brainstem,basal ganglia,cortex,spinal cord,mouse genetics,virus tracing,behaviour
Everyday Life Radar Sensors For Transportation (ELIRAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2016-02-01
End date: 2018-07-31
Duration (months): 30.0
Total project cost (EUR): 2407962.5
EU funding (EUR): 1685573.0
Participants: 1
Project status: CLOSED

Everyday Life Radar Sensors For Transportation In the project ELIRAD we plan to further develop a cutting-edge radar sensor from the feasibility demonstration level to industrial readiness and maturity for market introduction. The developed sensors will support disruptive transportation applications and emerging markets. High-precision distance and velocity sensing is essential for a great variety of upcoming autonomous transportation systems like civil micro-drones, robotics, fully-automatic transport systems as well as autonomously driving cars. Silicon Radar (SiR) - with eight years experience in development and series production of radar chips - has developed a new generation of leading edge 120GHz radar sensors ideally suited for these systems. Our first-mover product will offer exceptional advantages and overcome drawbacks of current technologies. The sensor is a miniaturized but robust component for high-precision distance measurement; will consume significant less power, is dirt-immune and reliable; respects privacy. The radar sensor enables 360° true low-cost sense-&-avoid systems and thus will pave the way to wider acceptance of users and regulatory authorities. SiRs ultra-compact 120 GHz radar sensor is a result of the FP7-ICT project SUCCESS. Various prototypes where built; samples and evaluation boards where shipped to hundreds of customers. The reactions were constantly overwhelming. Positive feedbacks came from several companies with wide spectrum of applications ranging from industrial precision measurement up to obstacle detection in transport. The objective of ELIRAD is (i) to finalize the technical concept of serial production of the 120GHz radar sensor (high volume packaging and test concept) and (ii) to run a full chip qualification process, addressing reliable operation under a wide range of environmental conditions. We will conduct extensive tests of the circuits and modules verifying their readiness for transportation applications.

Keywords: 120ghz radar sensor,high precision measurement,low cost solution,low power solution,miniaturized front ends,enabling latest transportation applications
Do droughts self-propagate and self-intensify? (DRY-2-DRY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1465000.0
EU funding (EUR): 1465000.0
Participants: 1
Project status: CLOSED

Droughts cause agricultural loss, forest mortality and drinking water scarcity. Their predicted increase in recurrence and intensity poses serious threats to future global food security. Several historically unprecedented droughts have already occurred over the last decade in Europe, Australia and the USA. The cost of the ongoing Californian drought is estimated to be about US$3 billion. Still today, the knowledge of how droughts start and evolve remains limited, and so does the understanding of how climate change may affect them. Positive feedbacks from land have been suggested as critical for the occurrence of recent droughts: as rainfall deficits dry out soil and vegetation, the evaporation of land water is reduced, then the local air becomes too dry to yield rainfall, which further enhances drought conditions. Importantly, this is not just a 'local' feedback, as remote regions may rely on evaporated water transported by winds from the drought-affected region. Following this rationale, droughts self-propagate and self-intensify. However, a global capacity to observe these processes is lacking. Furthermore, climate and forecast models are immature when it comes to representing the influences of land on rainfall. Do climate models underestimate this land feedback? If so, future drought aggravation will be greater than currently expected. At the moment, this remains largely speculative, given the limited number of studies of these processes. I propose to use novel in situ and satellite records of soil moisture, evaporation and precipitation, in combination with new mechanistic models that can map water vapour trajectories and explore multi-dimensional feedbacks. DRY-2-DRY will not only advance our fundamental knowledge of the mechanisms triggering droughts, it will also provide independent evidence of the extent to which managing land cover can help 'dampen' drought events, and enable progress towards more accurate short-term and long-term drought forecasts.
Metabolic engineering of Ustilago trichophora: an isotope-assisted metabolomics approach for the improvement of malate production from glycerol (Meta-Origami)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Biodiesel production is usually accompanied by the production of 10% (w/v) glycerol as main low-value by-product, making it not yet economically competitive to petroleum-based processes. Recently, Ustilaginaceae fungi have attracted more attention due to their abilities of using crude glycerol to produce chemicals of industrial interest. Unlike established filamentous fungi, many Ustilaginaceae strains can grow in haploid and unicellular form, which are remarkably advantageous for industrial applications. Of note, U. trichophora was reported to have the highest titre for microbial malate production, even if the yield is still low. If the carbon lost during cultivation is suppressed, U. trichophora will be a novel candidate for industrial malate production and contribute directly to crude glycerol valorisation. However, the metabolic network and its function are not described for any Ustilaginaceae species. Isotope-assisted metabolomics approaches are powerful in exploring the metabolic network operation. By capturing the snapshot or the kinetics of metabolite pools, these approaches can guide metabolic engineering strategies to alter metabolic flux distribution and maximize target compound production. Therefore, this study aims to decipher the structure and dynamics of the metabolic networks of U. trichophora by using isotope-assisted metabolomics approaches. Results obtained in this research will guide ongoing efforts in metabolic engineering to maximize malate production from crude glycerol of U. trichophora. Further contributions will be made beyond the envisaged industrial applications, as the Ustilaginaceae are also investigated in the context of host-pathogen interactions and fundamental cell biology.

Keywords: metabolic engineering,isotope assisted metabolomics,ustilago trichophora,glycerol,malic acid
DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES (DECISION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Italy,Italy,Italy,Spain,Spain,Germany,Switzerland,Belgium,Sweden,France,France,Netherlands,United Kingdom,Denmark
Call: Systems approaches for the discovery of combinatorial therapies for complex disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-04-01
End date: 2025-09-30
Duration (months): 66.0
Total project cost (EUR): 6000007.13
EU funding (EUR): 6000000.0
Participants: 26
Project status: SIGNED

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. This mortality is mainly due to cirrhosis decompensation, i.e. development of ascites, hepatic encephalopathy, and/or gastrointestinal hemorrhage, and its progression to acute-on-chronic liver failure (ACLF). Patients with decompensated cirrhosis receive many treatments such as intravenous and oral absorbable antibiotics, oral non-absorbable antibiotics, albumin, proton-pump inhibitors, laxatives, diuretics, betablockers, vasoconstrictors, statins, anticoagulants, steroids and antiviral agents. Despite these multiple treatments, ACLF or mortality in patients with decompensation of cirrhosis remains high (15% at day 28, 28% at day 90) because of large interindividual variability in precipitating events, in clinical presentation and in response to treatment. This heterogeneity calls for treatment personalization according to underlying mechanisms. The objective of DECISION is to enhance our understanding, at systems level, of the pathophysiology of decompensation of cirrhosis leading to ACLF or death to decrease patients’ mortality at day 28. First, DECISION will improve our knowledge of the pathophysiology of decompensation of cirrhosis by integrating results of high-throughput multi-omic profiling with comprehensive clinical data from 2,200 fully characterized patients (more than 8,600 time points) with available standardized biological samples. Second, we will identify novel combinatorial therapies for patients with decompensation of cirrhosis to prevent death. We will refine these therapies in new and/or optimized animal models and then test the best combination in high risk patients in a phase II clinical trial built in DECISION. Third, we will develop 2 tests: one predicting outcome of patients with decompensation of cirrhosis when treated with standard treatment (prognostic test); and the other identifying patients who will respond to the novel combinatorial therapy (test for response).

Keywords: cirrhosis,decompensation of cirrhosis,survival,combinatorial therapy,infection,omics
European training Network for In situ imaGing of dynaMic processes in heterogeneous subsurfAce environments (ENIGMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Spain,Germany,Germany,Spain,Italy,Switzerland,Switzerland,Belgium,Belgium,Sweden,France,France,France,France,France,United States,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-01-31
Duration (months): 49.0
Total project cost (EUR): 3865769.64
EU funding (EUR): 3865769.6399999997
Participants: 22
Project status: CLOSED

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated technological developments and scientific findings will also contribute to monitor and model the environmental footprint of an increasing range of subsurface activities, including large-scale water abstraction and storage, enhanced geothermal systems and subsurface waste and carbon storage. While many subsurface structure imaging methods are now mature and broadly used in research and practice, our ability to resolve and monitor subsurface fluxes and processes, including solute transport, heat transfer and biochemical reactions, is much more limited. The shift from classical structure characterization to dynamic process imaging, driven by ENIGMA, will require the development of multi-scale hydrogeophysical methods with adequate sensitivity, spatial and temporal resolution, and novel inverse modelling concepts. For this, ENIGMA will gather (i) world-leading academic teams and emerging companies that develop innovative sensors and hydrogeophysical inversion methods, (ii) experts in subsurface process upscaling and modelling, and (iii) highly instrumented field infrastructures for in-situ experimentation and validation. ENIGMA will thus create a creative and entrepreneurial environment for trainees to develop integrated approaches to water management with interdisciplinary field-sensing methods and novel modelling techniques. ENIGMA will foster EU and international cooperation in the water area by creating new links between hydrogeological observatories, academic research groups, innovative industries and water managers for high-level scientific and professional training.

Keywords: hydrogeophysics,innovative sensors,in situ monitoring,subsurface hydrology,reactive transport,joint inversion of multiple datasets,predictive modeling,uncertainty assessment