Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fabricating Non-Invasive Temporal Interference Devices for Obstructive Sleep Apnea which Electrically activate the Hypoglossal Nerve (FitSleep)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 182142.86
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Obstructive sleep apnea (OSA) is a highly prevalent disorder characterized by episodes of decreased or absent inspiratory airflow during sleep. OSA is the world’s second-most common sleep disorder, plaguing over 1 billion patients worldwide with relentless, disruptive periods of restricted airflow during sleep. This can have dramatic effects, ranging from excessive daytime sleepiness to other comorbidities such as stroke, hypertension or depression. The effects of this disorder are pervasive and far-reaching, as diminished sleep quality eventually reduces general quality of life. Positive airway pressure (PAP) delivered through a tight-fitting mask is currently the most advanced technique for preventing airway collapse or airway narrowing during sleep, and is considered the primary treatment option for patients with moderate to severe OSA. However, despite improvements in quieter pumps and more comfortable masks, this approach has several disadvantages and patients very often struggle to comply with the therapy. We have recently shown that a non-invasive form of HNS can be effective in treating OSA patients by using temporal interference (TI) , a new non-invasive electrical stimulation technology which has been successfully advanced also for other clinical applications by the PI. Our device revolutionizes sleep apnea treatment with the efficacy of upper airway stimulation, without requiring surgery. Our proprietary new technology generates comfortable electrical fields which activate the tongue muscle and open airways. Its effectiveness is comparable to the best in market, while remaining non-invasive and financially accessible. FitSleep is an essential part of our exploitation strategy, which will ensure we advance the technology from TRL4 (currently) to TRL5. This will give us an ideal position for a subsequent EIC Transition application.
Guidance of axonal pathfinding via nano-switches (GAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2440000.0
EU funding (EUR): 2440000.0
Participants: 1
Project status: SIGNED

Axon navigation is guided by spatial patterns of chemical and physical cues in the developing brain. After a damage, the pattern is lost. Axons do not have instructions to reach their target. Axon regeneration, if stimulated, occurs by chance. Unfortunately, current technologies do not allow us to control axon navigation decisions, and guided re-innervation is not possible in the central nervous system (CNS). The GAP project aims to fill this knowledge gap by modulating neuron mechanotransduction, in order to program axon pathfinding and to differentiate axon navigation decisions. Cells will be engineered to express magnetic nano-switches that can generate forces in specific nano/micro domains of specific neurons. Depending on the domain, the force triggers a different mechanotransduction pathway, resulting in axon elongation or axon retraction. The integration of the different outputs from different neurons can be used to re-shape the network. GAP will demonstrate the ability: i) to change navigation decisions (e.g., to guide axon elongation in the direction of a repelling cue or to disengage axon outgrowth mediated by an attracting cue); ii) to differentiate between different navigation decisions in a mixed neuronal population (e.g., excitatory versus inhibitory neurons); iii) to control axon navigation decisions in a living organism (e.g., promoting reinnervation of excitatory neurons in models of spinal cord injury). GAP would demonstrate the ability to control neural network remodeling which remains an unmet challenge for science.

Keywords: neuron,axon pathfinding,navigation decision,mechanotransduction,magnetic nanoparticle,nanomedicine,rational cell engineering
SEAClim: European SEAs CLIMate impact prediction through regional models (SEACLIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: France,Norway,Spain,Sweden,Portugal,Germany,United Kingdom
Call: Ocean models for seasonal to decadal regional climate impacts and feedbacks (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4499826.25
EU funding (EUR): 4499826.25
Participants: 13
Project status: SIGNED

SEACLIM aims to provide refined information on future decadal-to-multidecadal changes of the marine environment and related impacts at regional to local scales, fundamental for climate policy and decision making. SEACLIM will leverage on regional ocean models of the Copernicus Marine Service to enable for the first time the pre-operational prediction of decadal and multi-decadal changes of the marine environment (ocean circulation, waves, sea-ice, biogeochemistry) through coordinated downscaling of the latest global climate models reference simulations (CMIP6). SEACLIM will also advance the understanding of physical and ecosystem processes to further develop regional ocean models. New regional ocean indicators will be developed to assess the ocean state and health over coming decades. SEACLIM R&I will be performed over three European seas: the northeastern Atlantic, northwest shelf including the North Sea and the Arctic Ocean, but will be replicable to other regional seas. SEACLIM regional ocean predictions, projections and ocean climate indicators will be integrated in the European Digital Twin of the Ocean, providing it with climate ‘what-if scenarios’. SEACLIM new datasets will be benchmarked in coastal and ocean climate services for targeted policy and decision makers to support climate mitigation and adaptation actions and the blue economy. SEACLIM will co-design its R&I and exchange knowledge with key stakeholders and will bridge the gap between the operational oceanography and climate science research communities, ocean modelling and programmatic frameworks (e.g., Copernicus, WCRP CMIP, CORDEX, CLIVAR, RiFS, WMO, GOOS). A coordinated framework for regional ocean decadal to multi-decadal predictions and their evaluation will be co-developed to build capacity of the regional ocean climate community to produce coordinated simulations and pave the way for the development of a new service line on projected changes of the marine environment in Copernicus Marine.

Keywords: regional ocean models,downscaling,climate projections,decadal predictions,marine ecosystems,ocean indicators,ocean climate services,what if scenarios,ne atlantic,arctic ocean,north sea
Society and Culture, Climate Change and Environmental Challenges, Health, Artificial Intelligence: DOC (SCHADOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,United Kingdom,Belgium,Germany,Switzerland,Italy,Sweden
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 4032000.0
EU funding (EUR): 4032000.0
Participants: 19
Project status: SIGNED

SCHADOC stemmed of regional actors’ will to attract promising Early-Stage Researchers (ESR) to the South-East region of France by offering them an interdisciplinary, intersectoral and international training program of excellence. SCHADOC is an essential building-block in the larger transformation strategy of AMU’s graduate education. It aims to recruit 40 ESRs for 36-month thesis projects. Two calls for candidates will be launched during the first 2 years of the program which will be spread over five years. Applicants will be selected through a rigorous, transparent, open and merit-based selection process, involving various independent national and international experts. The selection process offers the possibility to grant bottom-up thesis projects proposed by the ESR as well as top-down projects proposed to the supervisors. ESRs will follow a training program both on research skills and on non-research oriented transferable skills. They will perform secondments both with a socio-economic and cultural partner and with an international partner. CIVIS alliance will be an asset to implement this international dimension of SCHADOC. This ambitious doctoral training program will improve the employability of the ESRs. Its success will be measured by the excellence of the research projects it will generate in strategic domains for the Region; the partnerships it will develop with the non-academic sector; and the attraction of a large number of international, talented researchers at the Aix-Marseille site. The scientific scope of SCHADOC covers four thematic cross-cutting and interdisciplinary research axes which are in line with the priorities of the SUD Region: - Societies and culture - Climate change and environmental challenges - Health and well-being - Artificial Intelligence and its applications

Keywords: doctoral training,interdisciplinarity,intersectorality,international,climate change,environment,health,artificial intelligence,societies,culture
In-Depth Dynamical Structural and Optical Study of Unconventional Au Based Plasmonic Core@ Catalytic Shell Antenna-Reactor System by Electron Microscopy and Simulations (HotElecTEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-15
End date: 2025-12-14
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Noble metal nanoparticles (Au, Ag, Cu) show unique optical properties called localized surface plasmon resonances (LSPR) when interacts with external electromagnetic (EM) waves in the UV-Vis-NIR region. Surface conduction electron of these nanomaterials can gain a huge amount of energy from the decay of the LSPR (Hot electrons) and can drive chemical reaction at the nanoparticle surface. Various metal-semiconductor combinations were observed to generate hot electron, but their catalytic efficiency is very low due to the presence of the Schottky barrier at the interfaces. Plasmonic metal-catalytic metal combination is a major breakthrough in this aspect and was observed to show very good catalytic efficiency contributed by hot electrons. However, they suffer from major structural instability during the reaction condition. Which is inherent in the conventional 3H-hexagonal closed-packed (HCP) structures of these plasmonic nanostructures. Unconventional plasmonic nanostructures of 4H/2H-HCP configuration is considered to have higher mechanical and structural stability compared to the conventional one. In this project, we will look into the hot-electron generation and transfer mechanism of novel bi-metallic unconventional Au nanotriangle (AuNT)@Pd and AuNT@graphene antenna@reactor system in nanoscale spatial resolution experimentally using electron energy loss spectroscopy (EELS) in aberration-corrected transmission electron microscope (Ac-TEM) and theoretically using time-dependent density functional theory approach. Besides TEM, the nanostructures will be characterized using other high end characterization tools to investigate their structural, optical and chemical properties. Stability of the nanostructures during reaction condition will be studied extensively using dynamical in-situ heating/cooling and biasing holder in an Ac-TEM. These studies will of extreme important to develop next generation photocatalytic materials to replace the conventional fossil-fuels.

Keywords: electronic properties of materials,surfaces,interfaces,nanostructures,etc,nanophysics nanoelectronics,nanophotonics,nanomagnetism,nanoelectromechanics,etc,photocatalysis
A Global Consensus? The Contested History of Structural Adjustment in the Age of Shock (ShockAge)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1471927.5
EU funding (EUR): 1471927.0
Participants: 1
Project status: SIGNED

The history of the late 20th century international political economy – from the 1973 oil crisis to the fall of the Iron Curtain in 1989 – is often told as a succession of shocks. It has been argued that the resulting disorientation allowed for the global imposition of “structural adjustment”: policies favoring the removal of state regulations and subsidies, the privatization of public assets and services, and the liberalization of trade and foreign investment – “neoliberal globalization” to some. Others argue that there was simply no alternative to these policies because of economic constraints at the time. Accepting neither the imposition nor the no-alternative thesis, ShockAge posits that there were political choices in the South, East and West within a constrained field of maneuver. The project rejects the narrative of a quasi-natural global takeover of neoliberal ideas and instead emphasizes the highly contested nature of the “neoliberal turn”. By going beyond the national or regional level and transnational global (dis)connections, it inquires how structural adjustment became a global phenomenon in the first place. In four subprojects, ShockAge will investigate the contestation of structural adjustment and inquire about the room for maneuver by different actors and the alternatives pursued: 1) at the international/intergovernmental level (focusing on the “Group of 77” of self-described developing countries), 2) at the level of international financial organizations (World Bank and International Monetary Fund), 3) at the national level (Bolivia, a key site of structural adjustment), and 4) at the transnational activist level (“anti-globalization” protests in divided Germany). ShockAge uses a global history approach to revise our understanding of a hinge moment in recent history and breaks new ground in the entangled histories of the North-South confrontation, neoliberalism, international organizations, and popular challenges to late 20th-century “globalization.”

Keywords: north south conflict,international organizations,international financial institutions,international political economy,neoliberalism,anti globalization,transnational activism
Twinning to address the PFAS challenge in Serbia (PFAStwin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Spain,France
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 1182431.25
EU funding (EUR): 1182431.25
Participants: 3
Project status: SIGNED

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used for more than 60 years to make plastics, firefighting foams, and lubricants, and help create stain-resistant, waterproof, and nonstick products. However, they ended up in the environment and now can be found in the soil, water, sediment, accumulated in human bodies and represent a worldwide challenge. The Serbian national chemicals legislation recognizes these chemicals, but none of the existing scientific or governmental institutions analyze these compounds. In addition, a solution to the challenge of remediation is not in sight. Based on a number of publications in peer-reviewed journals, a number of international projects, and a number of students, the University of Belgrade, Faculty of Chemistry (UBFC) is one of the leading scientific institutions in Serbia. This project aims to enhance networking activities between UBFC and two top-class counterparts, who are leaders in PFAS analysis (CSIC from Spain) and innovative (bio)remediation of emerging pollutants (BRGM from France). In addition, this project will focus on strengthening the research management capacities and administrative skills of the Grant Office from UBFC. This will be conducted through the development of a scientific strategy for dealing with PFAS (WP1), knowledge transfer in the field of analysis and (bio)remediation of emerging pollutants (WP2), networking and promoting joint research integrating creativity and developing new approaches for PFAS remediation (WP3), capacity building of the UBFC Grant Office (WP4), and through dissemination, exploitation and communication (WP5). The expected impact of PFASTwin is to enhance the reputation, research and administrative profile, and networking channels of UBFC and improve its capability to compete successfully for national, EU, and international research funding while simultaneously benefiting partner institutions through new contacts, skills, and collaborations.

Keywords: pfas,analysis,bioremediation,capacity building,networking,grant office
Bioavailable iron delivery systems derived from plant sources (FooDIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Iron deficiency is a known public health concern, particularly for vulnerable groups (children and pregnant women), affecting around 1.62 billion people worldwide. In plant-based diets, the sources of iron are non-heme, less bioaccessible compared to the iron (heme iron) found in animal products. Despite its prevalence, effective dietary interventions focused on micronutrients deficiencies remain limited, mostly due to a lack of understanding of the fate of iron carriers during digestion of complex foods. The objective of FooDIS is to fill this research gap, focus on the fate of bioavailable iron during in vitro digestion and adsorption, to assist in the design of sustainable and innovative iron-rich foods. FooDIS will explore the potential of phytoferritins, plant iron-binding proteins, as effective carriers of bioavailable non-heme iron in plant-based foods. The hypothesis is that phytoferritins can be used as iron carriers, by creating specific interactions with other food components. By testing this hypothesis, we will learn how to enhance the bioavailability of non-heme iron in plant-based foods. The objectives of FooDIS will be achieved through a multidisciplinary approach, integrating the study of phytoferritins digestion in food using INFOGEST-standardized protocol, advanced spectroscopy (synchrotron) and ICP-MS analyses, and in vitro absorption models containing mucus-producing cells (Caco2/HT29MTX). The study, starting with simple and moving to complex model systems, will bring detailed insights of the fate of iron during digestion and its absorption, but also analyze iron speciation and interaction with other food components, leading to new, important discoveries on the mechanism of gut iron absorption. The outcomes will have societal and scientific impact, providing knowledge for the design of novel plant-based iron delivery systems, not only contributing to address the nutritional needs of more sustainable diets but to improve global health outcomes.

Keywords: iron,complexes,digestion,delivery systems,matrix,plant based,micronutrients,deficiency
Unique ALD/MLD-Enabled Material Functions (UniEn-MLD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 2499645.0
EU funding (EUR): 2499645.0
Participants: 1
Project status: SIGNED

UniEn-MLD research seeks the extremity of the atomic/molecular layer deposition (ALD/MLD) thin-film technique to enable unforeseen material functionalities. The targeted metal-organic materials and interface-engineered superstructures are designed and elaborated so that the unique advantages of this atomic/molecular precision gas-phase synthesis approach can be best exploited. New science evolves from our aim at (i) unique material assemblies (bonding schemes, crystal structures, layer piling sequences, interface interactions) not accessible through conventional synthesis, and (ii) synergistic combinations of different material functionalities, also such which would be mutually exclusive in conventional materials. An important project part is the search for new innovative organic components capable in bringing, e.g., structural guidance, redox control, carrier doping or stimuli-switching into the hybrid material, to create the desired functionalities. The technical advantage follows from the specific ALD/MLD mechanism which yields the new adventurous materials as high-quality large-area homogeneous and conformal coatings, even on demanding surfaces. This opens attractive new avenues for technology advances in important and strongly emerging fields, such as efficient magnetic information storage and local energy harvesting and storage, also addressed within the UniEn-MLD action. This project builds on my long experience in frontier functional material research, and my pioneering role in the development of the ALD/MLD technology for building a beautiful variety of intriguing metal-organic materials. Our proof-of-concept results also support the main hypotheses and feasibility of this ambitious UniEn-MLD research.