Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microneedle-assisted nanovector skin patch for immunomodulation of the inflammatory response upon occurrence of myocardial infarction injury (MiNeMi) (MiNeMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

Cardiovascular diseases are the leading global cause of death, being ischemic heart disease one of the deadliest. To date, the conventional therapeutics only ameliorate the state of care of myocardial infarction (MI) patients, and no approved therapy has been developed for heart scars. Promising approaches might come based on the latest knowledge on new pathophysiological concepts, e.g. on the inflammation and immune responses upon MI. The inflammatory phase on MI presents itself as a therapeutic opportunity, with immunomodulation for heart regeneration showing great promise for MI treatment. Thereby, MiNeMI aims to answer the question if it is possible to modulate the immune system to regulate inflammation and promote heart regeneration through a non-invasive approach. To this end, MiNeMI will, for the first time, develop a novel and unique double-layer biodegradable non-invasive microneedle (MN)-assisted nanovector skin patch, loaded with both immunomodulatory and biologic (cytokines, proteins, and extracellular vesicles) cargos to be tested in a myocardial infarction (MI) disease model. The MN-patch approach proposed here will deliver the cargos into the dermal layer of the skin, a reservoir of immune cells, and will revolutionize the way to regulate the inflammatory systemic immune response upon cardiac ischemia. This MN-assisted nanovector skin patch will be fully characterized in vitro for immune and cardiac effects and also tested in animal MI disease models.

Keywords: microneedles,immunotherapy,myocardial infarction,inflammation,nanoparticles,nanovectors,biomaterials
Generation of therapeutic antibodies targeting type 2 Innate Lymphoid cells in asthma (MInfla-Tilc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We are proposing to target Innate Lymphoid Cells 2 (ILC2s), a subset that has been frequently implicated in inflammatory diseases, such as severe asthma. ILC2s are major players in allergic asthma and are abundantly present as tissue resident cells in the lung, both in human and mouse. Strikingly, the induction of allergic asthma in a mouse model deficient in ILC2s is abolished. In addition, the transfer of ILC2s back in the same mouse recapitulates the pathology. Mechanistically, activated ILC2s are the main producer of type 2 cytokines that sustain the chronicity of asthma by recruiting other inflammatory and pathogenic cells, notably eosinophils, and finally drive hyperresponsiveness and mucous hypersecretion. In humans, ILC2s are increased in the peripheral blood mononuclear cells (PBMCs) of patients with allergic asthma compared to healthy controls. They are also found in sputum and PBMCs of patients with severe, eosinophilic asthma compared to mild forms of asthma. Collectively, these data highlight the significance of ILC2s in allergic inflammation and emphasize the idea to target those cells for therapeutic purposes. MInfla-Tilc is a translational and integrated project aiming to launch an innovative therapeutic monoclonal antibody (mAb) treatment against ILC2s to control severe asthma.

Keywords: innate lymphoid cell,ilc2,inflammation,lung,monoclonal therapeutic antibody,crth2,asthma,cell depletion therapy
Increasing IVF success rate through the first magnetic resonance system for embryonic quantitative analysis at the cell scale (Embryospin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today 1 out of 6 couples turn to the In Vitro Fertilization (IVF) technique to fulfil their desire of starting a family. Despite decades of research and high costs, the success rate of IVF remains frustratingly low (33%). A key factor in determining the IVF success is the embryo screening to determine viability. Surprisingly enough, embryo selection is currently performed through optical analysis with a microscope, that is a purely morphological, qualitative assessment that provides no reliable insights on embryo viability. Other available techniques are costly and invasive, since require the use of chemical labels or even a tissue biopsy. Annaida Technologies has developed Embryospin, a patent-filed device that performs microscopic Nuclear Magnetic Resonance (microNMR) at a scale of 100 microns, a 10-fold improvement over existing technologies. Annaida will develop and commercialize an NMR bench-top device, coupled with a disposable microNMR sensor able to screen up to 10 embryos in less than an hour. The technology is poised to radically increase the IVF laboratories’ success rates, thus ensuring significant savings to infertile couples and also to National Healthcare Systems that subsidize IVF costs, like France, Belgium and Germany. The Phase 1 project will be a launch pad for the future commercialization of the system, enabling to validate the Embryospin performances and the market opportunity, determine the most suitable pricing strategy, and refine the business plan to attract the future investment needed for scaling up the production. The following step will be to proceed with system engineering and preparation to the in-field validation (Phase 2) together with large prospective customers, which will pave the way to the beginning of the commercialization phase in 2021.

Keywords: embryo selection,embryo biochemistry,nmr device
Rural-Urban Outlooks: Unlocking Synergies (ROBUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Germany,Italy,Austria,Germany,Germany,Belgium,Finland,Slovenia,Latvia,Latvia,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Consolidated policy framework and governance models for synergies in rural-urban linkages (H2020-RUR-2016-2, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 5999937.5
EU funding (EUR): 5999934.0
Participants: 25
Project status: CLOSED

Mutually beneficial relations along rural – peri-urban – urban trajectories can contribute substantially to Europe’s smart, sustainable and inclusive growth agenda. Success in creating synergies is largely determined by decisions made at local and regional levels. Well-designed governance arrangements can be conducive to decisions that strengthen beneficial relations between rural and urban areas. Central to ROBUST is a place-based case study approach in which the case studies focus on thematic functional linkages cutting across rural-urban areas. The content and governance of these functional linkages are analyzed in diverse case study areas that represent the main types of rural – peri-urban – urban settings across Europe. ROBUST will identify and strengthen policies, governance systems and practices that can contribute more effectively to smart, sustainable and inclusive growth. Particular attention will be paid to the capacities of municipal and regional governments, the related administrations and other stakeholders to deliver and enhance mutually beneficial relations. ROBUST aims to provide practice-oriented information about successful governance models applicable to different settings as well as related communication and training material. In ROBUST, the questions and research needs of practice partners will guide the research process. Researchers will support the related multi-actor consultations through data collection and analysis, by providing suitable platforms and through facilitation. The insights co-generated by research and practice partners and stakeholders will be translated into tools, including scenario development, as well as training materials and capacity building measures. ROBUST will in this way contribute to a better understanding of rural-urban interactions, and it will at the same time enhance the capacity of relevant actors and institutions to foster mutually beneficial relations along rural – peri-urban – urban trajectories.

Keywords: functional rural urban linkages,rural urban synergies,smart,sustainable and inclusive growth,governance arrangements,cross sectoral cooperation,capacity building
Thermodynamics of Quantum Transport (QFluctTrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Electronic components are shrinking and finally reaching the scale of single molecules; promising novel applications to sensors, photovoltaics, heating and electronics. As these components get smaller, important and new physical phenomena impose limitations on how these devices can operate. Quantum mechanics and non-equilibrium thermodynamical fluctuations dominate, challenging all the conventional engineering tools accepted in electronics. The objective of this proposal is to use the novel tools from quantum non-equilibrium thermodynamics to understand the effects of fluctuations in transport in such devices. Average quantities that were good to characterize and control devices in the classical scale become inadequate, as the fluctuations of single trajectories of particles become very large. Although much work has been done to understand quantum thermodynamics, many questions are open regarding its impact on transport on molecular devices. The objective we propose will be addressed by research focused on overcoming the following challenges: (i) Understand the effect of quantum coherence as a thermodynamic potential in molecular devices. (ii) Apply the Open Quantum Systems TD-DFT functional to model transport in molecular devices (iii) Develop a consistent method to characterize transport devices with large quantum fluctuations Each of these rely on existing theoretical techniques, but they have not been used together for the proposed purpose before.
NEOSONICS – First non-invasive screening medical device for infant meningitis. (NEOSONICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bacterial meningitis is one of the most serious infections for infants and children, which is associated with acute complications and chronic morbidity. Untreated bacterial meningitis is highly fatal, leaving serious neurological sequelae in survivors and crippling children for their life. Because the prognosis worsens with delayed treatment, early detection aids clinician in providing a timely intervention, to institute, appropriate antibiotic therapy. However, detection of meningitis can be challenging due to the minimum symptomology of the disease and particularly in newborns and young infants, the most vulnerable since their immunological system is yet being developed, for their inability to communicate. Paediatricians have the daily challenge of diagnosing 2.5M infants younger of one year in Europe each year who may have only fever that may be caused by an infection and, although the incidence is relatively low, it can be meningitis. The only method to detect the presence or absence of the disease is a lumbar puncture, an invasive, cumbersome and time-consuming and cost-ineffective procedure that, in industrialised countries, is negative in 95% of cases. The imperious need for quick, easy and cost-effective detection makes Neosonic (NS) a unique solution for non-invasively screen for bacterial meningitis in infants. The innovative and sophisticated precision-engineering system using high-frequency ultrasound is placed in the fontanel of the infant, the area of the skull where bones remain unwelded for babies. With the push of a button NS measures the number of White Blood Cells in the CerebroSpinal Fluid. Therefore, only if CSF WBC count is increased should an LP be performed and antibiotic treatment for meningitis be administered. Furthermore, NS allows to follow up patient treatment response by means of monitoring CSF WBC concentration, which decays with a positive response. Currently, repeated LPs for follow-up are rarely performed due to its associated risk

Keywords: body fluid infection,meningitis,lumbar puncture
Regulation of plant receptor kinase-mediated immunity by endogenous peptides and their receptors (IMMUNO-PEPTALK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1999999.0
EU funding (EUR): 1999999.0
Participants: 1
Project status: SIGNED

Plant receptor kinases are major pattern recognition receptors (PRRs) that function as part of dynamic multimeric complexes to perceive pathogen-associated molecular patterns or host-derived damage-associated molecular patterns at the plasma membrane (PM). Our long-term objective is to decipher the molecular basis of plant innate immunity and to understand how plant receptor kinases work. Our recent findings point to an important role of endogenous peptides in the regulation of plant innate immune signaling. The main aim of this proposal is to understand how these endogenous peptides and their corresponding receptors regulate plant innate immune signaling. The central hypotheses of this research are that: (i) a subset of plant endogenous peptides are perceived by receptor kinases to fine-tune dynamically plant innate immune signaling, and thus act as ‘phytocytokines’; (ii) these phytocytokines and their receptors regulate the formation of active immune-signaling nanoclusters at the PM; and (iii) phytocytokine receptors participate in the sensory continuum represented by the plant PM and the cell wall to respond dynamically to environmental challenges. We will pursue the following specific objectives: (1) decipher the regulation, function, and perception of RALF peptides by malectin-like receptor kinases during immunity; (2) elucidate the formation, composition, and function of PM immune receptor nanoclusters; (3) reveal the function of the receptor kinase MIK2 and its ligand(s) in immunity. Through a balanced combination of straight-forward and high risk/high gain biochemical, biophysical, bioimaging, and genetics approaches, this project will provide groundbreaking insights into the molecular mechanisms underlying the establishment and regulation of plant innate immune signaling, but also into the general mechanisms that control plant receptor kinase functions and by which the myriad endogenous peptides encoded by plant genomes control environmental sensing.

Keywords: pamps,endogenous peptides,receptor kinases,plasma membrane
Catalytic META C-H ACYLation of arenes (METACYL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-16
End date: 2022-11-15
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Carbonylative C-H activations can lead to an unprecedented degree of molecular sophistication by combining the atom-economical insertion of CO with the green activation of unreactive C-H bonds. In striking contrast to ortho C-H acylation of arenes and heteroarenes (directing-group strategy) and para C-H ones (Friedel-Crafts chemistry), meta C-H acylations are almost completely unexplored. This proposal aims at the development of the first example of meta C-H acylation via mild carbonylation of arenes. Pivoting on this breakthrough, it will be possible to accomplish synthetic methods 1) for the efficient synthesis of hardly accessible organic compounds, 2) for the activation and carbonylation of meta C(sp2)-H bonds, 3) by employing transient directing group and 4) demonstrating the application of these protocols under continuous flow conditions.

Keywords: c h activation,acylation,carbon monoxide,palladium,sequential reactions
Roman Catholic laywomen’s “turn to habit” as a strategy of developing modern pious womanhood: Catholic female social reformers in France, Germany and Partitioned Poland between 1878-1914. (Habit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-05-01
Duration (months): 24.0
Total project cost (EUR): 172477.2
EU funding (EUR): 172477.2
Participants: 1
Project status: CLOSED

The project’s objective is to explain the meaning of habitual mental and bodily practices for the nineteenth century Catholic laywomen’s program of developing modern pious womanhood and further interprets those women’s interest in habit as part of the broader contemporary religious, intellectual, and socio-cultural inquisitiveness in routinized actions. The research employs a transnational approach privileging individuals, networks, and debates in France, Germany and Partitioned Poland between 1878-1914. The Catholic laywomen’s focus on habit will be retrieved through analyses of their pedagogical writings and educational models and subsequently confronted with contemporary conceptualizations of habitual action as found in the epoch-making theological, philosophical and scientific theories and selected social practices. It is argued that in a context in which women could formally engage with theology, philosophy and science in very limited ways those lay activists’ religious or pedagogical writings and educational practices were distinctive ways of participating in major contemporary disquiets over the limits of human agency and plasticity of human behavior. With their interventions in the concept of habit those Catholic laywomen joined the nineteenth century efforts of overcoming body-mind, freedom-necessity, and spirit-matter dualisms. The research adds to the field of women’s history by proposing new motives and periodization of the nineteenth century Catholic laywomen’s activism’s emergence and providing novel interpretations of their actions in a transnational perspective. This multidisciplinary project will expand my competences with insights from several fields of academic inquiry. Marie Curie Fellowship will provide me with triple experience as a researcher, project manager and a science communicator, which will give me confidence in planning, executing and delivering projects independently in the future.

Keywords: women s history,gender studies,religion,catholic movements
Sewage sludge reuse Phosphate recovery with an innovative HTC technology (HTCycle) (HTCycle)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Germany
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Efficient municipal wastewater treatment produces vast amounts of sewage sludge. The latest data show a yearly production of 9.637 thousands of tons in Europe. Sludge treatment issues are often neglected in comparison with water-related parameters which results in serious technical difficulties and highly expensive disposal methods. An energy efficient, environmentally sound and economically viable process for sludge disposal and reuse of valuable resources e.g. phosphorus hardly exists. The most common disposal methods for sludge are spreading on agricultural soil, composting and incineration. Landfilling has been long banned, the use as fertilizer, although very moderate in costs, is being banned in many regions due to concerns about contamination of soils with heavy metals and endocrine disruptive compounds. Incineration entails the highest costs (80-110 € /ton), but is also considered the safest disposal method and is fast growing and widely adopted. It presents also technical difficulties, such as the low overall efficiency of the process, the huge logistic efforts required to transport the sludge to the incineration plants, or the disposal of the ashes after the sludge has been incinerated. In this situation, the proposing company, AVA-CO2 has the objective to demonstrate and commercialize their proprietary technology for hydrothermal carbonization (HTC) to the conditions of sewage sludge, showing clearly technical and economic advantages against the current sludge incineration method. AVA-CO2 aims to increase the amount of sludge converted into high value products such as fuel, activated carbons for water treatment, recovered phosphorus, soil remediation material, carbon sequestration schemes and other applications. The HTCycle process turns the present sewage sludge disposal (incineration) from a costly process into an income-generating activity

Keywords: sewage sludge treatment and reuse,hydrothermal carbonization,resource efficiency,eco innovation,carbon products