Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FAMILY MATTERS: POST-NATAL SOCIALITY AND THE OUTCOMES OF MATERNAL STRESS IN A SOCIAL LIZARD (EGERNIALIZARDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-07
End date: 2022-01-06
Duration (months): 36.0
Total project cost (EUR): 232551.0
EU funding (EUR): 232551.0
Participants: 2
Project status: CLOSED

Mothers can alter the characteristics of their offspring through non-genetic maternal effects. For example, stress experienced by mothers during gestation can have organizational effects on offspring behaviour and physiology – such effects may substantially influence the subsequent success of these offspring. Theory suggests that, depending on the environment in which they occur, maternal effects have the potential to accelerate or constrain the rate, and alter the direction, of evolutionary change. It is therefore critical to know how ecological variation influences the outcomes of maternal effects, such as maternal stress effects, in order to understand the evolutionary importance of maternal effects in different species. A source of environmental variation likely to be important in determining the outcome of maternal effects, and maternal stress specifically, is the post-natal social environment – in other words, whether offspring remain with their mother/parents, or not. I propose an integrative research project to test how the outcomes of maternal stress are influenced by the post-natal social environment. To achieve this, I will combine a large-scale field experiment using a social lizard species (Liopholis whitii) in which the degree of post-natal mother-offspring association varies naturally, with physiological laboratory analysis and meta-analytical methods to: experimentally address how the post-natal social environment alters the effects of maternal stress on key phenotypic traits (such as growth, and dispersal and competitive behaviours), identify potential endocrinological and neurological mechanisms underlying these effects, and test the generality of these patterns across taxa in a meta-analytical framework. This work will provide novel insights into the long-term consequences of maternal stress-induced maternal effects for offspring fitness and the extent to which these effects may show the evolutionary and ecological trajectory of populations.

Keywords: maternal stress,maternal effects,lizard,evolution
Ethically Responsible INnovations in reproductive medicine (ERIN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Sweden,Netherlands
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-09-01
End date: 2023-12-31
Duration (months): 40.0
Total project cost (EUR): 899625.0
EU funding (EUR): 899625.0
Participants: 3
Project status: SIGNED

ERIN project was initiated to spread the academic excellence to University of Tartu (UT) in Estonia as representative of the Widening country, by enhancing networking activities with internationally-leading counterparts, Karolinska Institute (Sweden) and Maastricht University Medical Centre (The Netherlands). The consortium increases the scientific, innovation and clinical superbness of UT and its partners, by raising the R&I profiles, and the proficiency to identify, explore and resolve the ethical challenges in female reproductive medicine. We deal with the most intimate aspects of human life, by medically assisting conception, by carrying out a genetic analysis of an embryo or fetus to have a healthy baby, and by preserving fertility in women whose fertility is at risk. In the era of rapidly progressing technologies, novel solutions emerge fasten than the conclusive clinical evidence is collected and ethical challenges are addressed. Reproductive medicine is also often unsatisfactorily publicly supported, creating an inequality in access for the most vulnerable category of the patients, women waiting for childbirth. This is why reproductive medicine, covering human life from fertilization till birth, requires special attention to tackle all possible ethical concerns, risks and vulnerabilities, and involving all stakeholders, from individual patients to broad community. By addressing these challenges, we aim to bring more ethically responsible innovations into clinic that do not harm the interests of the various stakeholders, are evidence-based, cost-effective and therefore could be implemented in a sustainable way to ensure that these novel solutions become widely accessible. As an outcome, ERIN improves the responsible innovation practices, establish ethical system in R&I, expands knowledge and innovation capacity of the UT, and improves proficiency of all partners to facilitate the equity of access to research advances in reproductive medicine.

Keywords: personalized reproductive medicine,assisted reproductive technologies,non invasive prenatal testing technologies,female fertility preservation
A Soft Synergy-based Hand Prosthesis with Hybrid Control (SoftHand Pro-H)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy,Italy
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-03-31
Duration (months): 15.0
Total project cost (EUR): 149787.0
EU funding (EUR): 76037.0
Participants: 2
Project status: CLOSED

In the project “SoftHands” we have achieved not only a more thorough understanding of the organization and control of hands, but also a principled approach to taming the complexity of hand design. The original concept of “soft synergies” has underpinned the realization of radically new artificial hands: “SoftHands” have been demonstrated to be more adaptive and capable than most artificial hands, yet are simpler to control and more robust. One application of these ideas and technologies which stands out for potential impact and social relevance, although not originally foreseen in the ERC AG plan, is the realization of upper limb pros-theses. The objective to realize a prosthetic hand that is anthropomorphic, aesthetically pleasing, and enables an amputee to perform most activities of daily living as well as advanced prostheses, while being robust, intuitive, and economic as basic body-powered split-hook prostheses requires a much longer and larger re-search and development effort than an ERC POC can support. In this proposal we study the feasibility of applying the SoftHand technology to address one particular, but very important, objective, i.e. work-oriented prostheses. The specific requirements of these applications are high grip power, grasp versatility, resilience, resistance to water, dust, and temperature, durability, power autonomy and low cost – while factors such as aesthetics or silent operation are less dominant. Of particular relevance is the control interface with the patient. Virtually all work-oriented prostheses are operated via a body-powered cable, which is very intuitive to use and does not need batteries, motors, and sensors. On the other hand, advanced multi-fingered prostheses have sophisticated myoelectric control affording versatility and dexterity. In this project, we will engineer and experiment a novel hybrid control for a SoftHand prosthe-sis, whereby a traditional cable harness commands the advanced mechatronic system of the SoftHand.

Keywords: robotics,prosthetics,rehabilitation,assitive technology
Immune profiling to guide host-directed interventions to cure HBV infections (IP-cure-B)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Spain,Belgium,Greece,Sweden,Switzerland,France,France,France,France,United States
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 10343030.5
EU funding (EUR): 9983029.0
Participants: 17
Project status: SIGNED

The objective of the project is to develop novel curative concepts for chronic hepatitis B (CHB). Specific aims will be to: 1) improve the rate of functional cure of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine; ii) characterize immune and viral biomarker signatures for patient stratification and treatment response monitoring; iii) integrate biological and clinical data to model the best combination treatment for future trials; iv) model the effectiveness of novel curative therapies with respect to disease spectrum, patient heterogeneity, and constraints of National Health Systems. The project organization will combine: i) a Proof of Concept clinical trial of a combination of 2 novel compounds stimulating innate immunity; ii) a preclinical immune therapy platform in humanized mice combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses; iii) extensive virologic and immune profiling to identify correlates of cure in patients, iv) the integration of large biological and clinical datasets, v) a cost-effectiveness modelling of new therapeutic interventions, vi) project management, vii) results exploitation and dissemination. The proposal responds to the work program by: i) including the evaluation of emerging concepts in drug and vaccine development to discover a curative strategy for CHB, a major public health concern for Europe, ii) capitalizing on knowledge of host-pathogen interactions to develop novel immune-based therapies, iii) considering age, gender and viral genetic variations, iv) comprising a clinical trial and a pre-clinical platform for the discovery of novel immune interventions, and selection of relevant biomarkers for validation in established clinical cohorts, v) addressing conditions for effective uptake of the new curative interventions by National Health Systems.

Keywords: hepatitis b virus,viral persistence,immune therapy,cure of infection,animal model,clinical trial
Wavy N-doped Graphene Nanoribbons for Single Molecule Electronics (WavyRibbons)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-13
End date: 2021-05-12
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Graphene nanoribbons (GNRs) combine the advantages of pristine graphene with the semiconducting properties required for applications in organic electronics. The properties of GNRs are significantly dependent on their structural variables such as molecular length, width and edging structures. However, it remains quite challenging to achieve atomically precise control over the structures of GNRs simultaneously, therefore new synthetic approaches are highly desirable. In this proposal (WavyRibbons; Wavy N-doped Graphene Nanoribbons for Single Molecule Electronics), a novel synthetic approach is proposed to afford GNRs with controllable length, wavy (hybrid armchair and zigzag) shape and N-doping. The properties of these GNRs will be fully characterized. These structure defined GNRs bearing suitable ending groups also provide a unique platform to study the charge transport properties in single molecule junctions, which will shield new insights into this important but unexplored field. The appropriate working plan taking into account 1) background of the fellow; 2) experience of the host groups; 3) resources available will ensure the achievement of this proposal. And, the success of WavyRibbons will not also signify a real breakthrough in fundamental research but also benefit all the parties involved.

Keywords: graphene nanoribbon,charge transport,single molecule electronics,novel synthetic approaches,structure property relationship
Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation (InProSMod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

In the sensory cortex of awake mice, spontaneous activity has been shown to exhibit various regimes, characterized by various levels of spiking activity. Such diverse activity regimes, termed network states, have a profound impact on the computational properties during sensory processing. In the mouse barrel cortex, a major top-down pathway modulating sensory input is represented by the integration of inputs from the motor cortex and associative thalamus onto layer 1 (L1). Here I will characterize the synaptic and circuit properties underlying top-down control of sensory network states during whisking in L1. Using a combination of synaptic biophysics, in vivo electrophysiology, 2-photon imaging and theoretical modeling, I will define the important role of L1 interneurons in decoding top-down processing of sensory information. This research will generate valuable information to advance our knowledge of cortical circuit dynamics during normal cortical operations, with crucial implications for several brain disorders.

Keywords: neocortical circuitry,top down control,inhibitory interneurons,nmda receptor,modeling of recurrent dynamics,active sensation
INteractive CHarging (INCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Slovenia
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 1266812.5
EU funding (EUR): 886768.75
Participants: 1
Project status: CLOSED

The INteractive CHarging (INCH) project will introduce the next-generation charging station for electric vehicles (EVs), named Etrel Smartcharger. It will enable charging of an increasing number of EVs in a smart and sustainable manner, which is the only way to optimise energy use in transport and reduce related greenhouse gas emissions. In the long term, it will not be possible to use EVs without using solutions such as the Smartcharger. The Smartcharger is a new version of Etrel's current product generation, designed as a low-voltage AC charging station for use at homes, offices, and car parks. It will bring down the cost of smart charging infrastructure deployment where it matters the most (more than 90 % of charging takes place at home or at work). At the same time, it will bring the charging network to a new level, allowing each and every connected car to adjust its consumption to the needs of the energy grid. Market adoption of the Smartcharger will be driven mostly by EV drivers who require an interactive solution that can automatically charge their car in the desired time without overloading the circuit. The Smartcharger will allow each EV user to save 140 EUR per year in charging costs and will return the investment in 3-4 years, roughly a third of its lifetime. Users will be able to share control over their charging with power companies in exchange for financial compensation. This will give the power companies an option to control EV charging load, in order to reduce it in time of peak demand or use the batteries as a reservoir for electricity from renewable sources at times of high production. With an additional investment of 1.322.000 EUR, an estimated 67M EUR of profits and 65 new jobs within the company are expected over the course of 10 years after the end of the project. The INCH project will also present an enabling technology for the integration of EV charging into European smart grids and for the provision of new services in electromobility.

Keywords: electric vehicles,smart charging,power management,electromobility
Ultrafast, scalable disaster-proof client-side backup solution (iSave)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Hungary
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-03-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Everyday business of any company goes hand in hand with producing large amount of valuable data stored within the IT infrastructure of the company. Customer data, website content, mailing data, ERP files etc. are only a few examples of data which are crucial to be achievable, up-to-date and safe at any time. Their loss or damage causes significant financial losses to any company. Fortunately the use of backup and file recovery systems is obvious for more and more responsibly thinking companies. Cutting-edge technologies are available for them to secure their data. However current options do not provide a holistic solution. We, at iSave Ltd. created an innovative solution, which gives the security of a local backup, but with an ultrafast recovery speed and scalable system structure. Since we offer an efficient answer to their critical needs, prestigious companies like Deloitte, HBO and Kürt Inc. tested and appreciated our product, while expressing their willingness to buy. After a series of tests our partners have expressed that a key advantage for them is due to the client side backup technology. iSave is able to restore data for the user, not only by restoring the file structure and operation system, but also the user settings and preferences. Alternative solutions to restoring a personal computer would take one whole day (in average even more) and need personal involvement of the IT expert team. The same tasks for iSave data backup took only 15-20 minutes without the contribution of the IT team. The prototype and concept were already tested at prestigious clients but the iSave technology needs to be demonstrated in order to bring it to the world market. By carrying out the proposed Phase 1 project we aim to investigate willingness to buy and pay, designing the know-how protection, commercialization and production.

Keywords: cybercrime prevention,information security innovation,client side data backup,solid state drive,safe data storing,fast backup
The Making of the Byzantine Ascetical Canon: Monastic Networks, Literacy and Religious Authority in Palestine and Sinai (7th-11th centuries) (MonasByz)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

This research project will investigate the role played by the multilingual Christian monastic communities of Early Islamic Palestine and Sinai (7th-11th centuries CE) in the formation of the Byzantine literary canon of ascetic works. Throughout the Medieval period, Byzantine monks and ascetics across the Mediterranean relied as their main source of authority on the writings of the "early fathers", i.e. a series of ascetic authors who were active between ca. the 4th-7th centuries CE. The increasing spiritual authority invested in ascetic books and texts (the "classics") during the Byzantine period stands in stark opposition to the living examples of charismatic holy men and women who dominated Late Antique Christian discourses on asceticism. Although this shift from a personal to a literary type of authority had far-reaching consequences for the history of Byzantine Christianity, key questions with regard to the complex processes behind it never received an adequate treatment in scholarship: Where and when did the change take place and what was its scope? How did a "canon" of ascetic literature emerge, who carried out the selection of authors and works, and how was it disseminated? Employing innovative research methods from the fields of social and intellectual history, philology, manuscript studies and Digital Humanities, MonasByz argues that the fundamental shift occurred in Palestine and Egypt (Sinai) during the early Islamic period and that the monasteries of Mar Saba and St Catherine's played a pivotal role in this development. Through a systematic survey of the Greek, Syriac, and Arabic ascetic manuscripts produced in these centers between the 7th and 11th centuries, the project will identify the actors and resources involved in the production of books and reconstruct the local and supra-regional monastic networks, in order to trace the formation of a new way of disseminating spiritual authority via texts, which would prevail in the Byzantine period.

Keywords: byzantine monasticism,ascetic literature,syriac studies,arabic christianity,digital humanities,manuscript studies