Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Visualizing Death Inducing Protein Complexes (VIDEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Iran, Islamic Republic of,Spain,Spain,Ireland,Switzerland,Norway,Sweden,France,Czechia,Netherlands,Canada,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1237400.0
EU funding (EUR): 1237400.0
Participants: 12
Project status: SIGNED

Every day billions of cells die in our bodies as part of normal healthy processes. These cell deaths are called “regulated cell deaths” as they occur through the activation of genetically encoded molecular machinery. However, too little or too much cell death is the cause of various diseases and of illness caused by exposure to chemicals. Understanding these cell death processes and how they are controlled may lead to new treatments for disease as well as explaining why some chemicals are hazardous. Regulated cell deaths as exemplified by apoptosis, necroptosis, and pyroptosis are induced by the formation of protein complexes. Here, we will develop new molecular tools to visualize the formation of the protein complexes in live cells and tissues and then use these tools to study cell death in normal and disease processes. Our consortium includes cell death experts, bioluminescence experts, zebrafish experts, as well as structural, developmental, molecular and cell biologists in industry and academia. The proposed research network will provide intersectoral mobility between laboratories expert in complementary skills. This will drive the development of the new tool and enhance the researchers’ career prospects. The research is of importance to many citizens of the EC; it will contribute to increasing food security by improving aquaculture, improving the health of aging populations through the study of degenerative diseases, improving toxicity assessment to better protect citizens from chemical hazards and improving the drug-development by better identification of adverse effects. Moreover, the assays emerging from the research will be commercialized by the industrial partners in the network, so supporting economic development within the EU.

Keywords: apoptosis,necroptosis,pyroptosis,split protein complementation,bifc
Software Quality Assurance for Microservice Development Operations Engineering (uDEVOPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Italy,Cyprus,Netherlands
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-03-01
End date: 2025-05-31
Duration (months): 63.0
Total project cost (EUR): 749800.0
EU funding (EUR): 749800.0
Participants: 6
Project status: SIGNED

The objective of the μDEVOPS project is to form an international and inter-sectoral network of organisations working on a joint research programme in the field of Software Quality Assurance (SQA) for Microservice Development Operations (μDevOps) engineering processes. The project will involve early-stage and experienced researchers giving them the opportunity to develop and exchange skills and knowledge to progress towards key advances in the μDevOps SQA field and strengthen collaborative research between different countries and sectors. The proposed action intends first to promote a cultural shift that places testing as a key cornerstone between the development and operation phases. Toward this long-term objective, the proposers will implement a joint research program aimed at i) fostering knowledge development and exchange between participants, ii) creating a long-lasting research network and iii) boosting research and innovation capacity of participating organisations. The knowledge exchange program will focus, as main scientific objective, on the study, definition and implementation of a testing process for μDevOps that integrates algorithms, techniques and methods for: i) model-based context learning, aimed at context-aware testing; ii) in-vivo reliability, performance and security sampling-based testing driven by the learnt context; iii) risk assessment aimed at estimating, based on test results and field data, the business risk associated with the usage (and possible failure) of each functionality, thus supporting risk-based prioritisation of SQA tasks. In the long term, the project aims at implementing the know-how and breakthroughs for novel products, methodologies and services and creating strategic bases to deal with the SQA challenges in modern software production practices. This will enable participating SMEs to resist market competition, proposing new methods and tools for agile development , V&V and maintenance along the whole chain of SQA

Keywords: service oriented archtiecture,microservice,devops,agile processes,software quality assurance,software testing,reliability,performance,security,vandv,monitoring,modelling,simulation
Superconducting magnets for the European Magnet Field Laboratory (SuperEMFL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Belgium,Switzerland,Slovakia,France,Netherlands,Netherlands,United Kingdom
Call: Design Studies (H2020-INFRADEV-2019-3, 2019)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2904356.25
EU funding (EUR): 2904356.25
Participants: 11
Project status: SIGNED

The magnetic field is a powerful thermodynamic parameter to influence the state of any material system and such is an outstanding experimental tool for physics. To go beyond the conventional commercially available superconducting (SC) magnets, very large infrastructures such as the ones gathered within the European Magnetic Field Laboratory (EMLFL) are necessary. EMFL provides access to static resistive magnets (up to 38 T) and pulsed non-destructive (up to 100 T) and semi-destructive (up to 200 T) magnets for all qualified European researchers. Some recent advances open the way for the implementation of high temperature superconductor (HTS) magnets at the EMFL facilities. The SuperEMFL design study aims to add through the development of the HTS technology an entirely new dimension to the EMFL that go beyond the commercial offer, providing the European high field user community with much higher SC fields and novel SC magnet geometries, like large-bore-high-flux magnets or radial access magnets. The development of SC magnets that can partly replace current high-field resistive magnets will result in a significant reduction of the energy consumption of the static field EMFL facilities. This will strongly improve EMFL’s financial and ecological sustainability and at the same time boost its scientific performance and impact. The high field values, the very low noise and vibration levels, and the possibility to run very long duration experiments will make high SC magnetic fields attractive to scientific communities that so far have rarely used the EMFL facilities (NMR, scanning probe, Fourier transform infrared spectroscopies, ultra-low temperature physics, electro-chemistry …). All these new research possibilities will strengthen the scientific performance, efficiency and attractiveness of the EMFL and thereby of the European Research Area (ERA). The implementation of this strategy should therefore be considered as a major upgrade of the EMFL.

Keywords: very high field superconducting magnets,high temperature superconductor insert
A gene expression test in blood for breast cancer (BLOBREC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-05-01
End date: 2016-04-30
Duration (months): 12.0
Total project cost (EUR): 143933.0
EU funding (EUR): 143933.0
Participants: 1
Project status: CLOSED

The aim of BLOBREC is to develop a blood-based test for the diagnosis of breast cancer. The test is based on results from gene expression analyses in a hospital based nested case-control study in the Norwegian Women and Cancer postgenome cohort study. The controls are healthy population controls from the same cohort. The innovative potential of a gene expression test is the independency from other test for breast cancer like imaging technologies (mammograms, ultrasound, MR) and pathological diagnosis. As such it could be used by itself or in combination with these other technologies. The idea has been considered by the International Search Authorities to be novel and inventive and thus, considered to be patentable. Further analyses should be run to improve the predictive values of the test together with an external validation. The scenarios of use will be discussed. Based on this work comprehensive documentation should be available for commercial partners. Through collaboration with a technology transfer institution the potential approaches to commercial companies should be explored before any negociations. The idea could have important social and clinical implications through improved diagnosis of breast cancer given the increasing incidence of this disease in many countries worldwide.

Keywords: breast cancer,diagnostic test,gene expression,blood
Wearable Cardiorespiratory Monitor (WECARMON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-09
End date: 2020-12-03
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

The research topic of WECARMON deals with biomedical signal processing, specifically, the analysis of electrocardiogram (ECG) signals for cardiorespiratory system assessment. WECARMON’s main objective is to develop novel system for early non-invasive detection of clinical destabilizations of patients with chronic respiratory diseases, e.g., chronic obstructive pulmonary disease (COPD) and asthma. Its innovative nature is based on two main tools: 1) a long-term (months) wearable ECG device which uses dry electrodes which causes no skin irritation and which are placed in a left leadless armband, and 2) signal processing techniques for estimating respiratory rate and volumes from ECG which are robust against artefacts generated by movements during daily life. Chronic respiratory patients are affected by destabilizations (or “exacerbations”) which makes them to seek medical help and often lead to their hospitalization. Exacerbations can start quickly (in minutes to hours) and they are one of the main causes of mortality among patients with COPD and asthma which are the two most common chronic respiratory diseases, affecting millions of children and adults. Among the wide range of applications of a wearable cardiorespiratory monitor related to intensive care units, respiratory disorders and health monitoring, the chosen application of WECARMON is the daily ECG and respiratory monitoring in COPD and asthma patients for early detection of exacerbations allowing a better prognosis of the patient and a reduction of financial costs to society. WECARMON can be divided in 2 phases: 1) Development of a long-term (months) wearable ECG and respiration monitor, and 2) Development of an automatic algorithm for early detection of COPD and asthma exacerbations, based on cardiorespiratory parameters (e.g., heart and respiratory rates, tidal volume, minute ventilation).

Keywords: biomedical signal processing,electrocardiography,respiration,wearable devices
Healing Exosomes for sKIN (HEXKIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Portugal
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently, there are about 50 million reported cases globally of patients suffering from hard-to-close wounds, which constitute a severe cost burden to the global healthcare systems. Considering that for these patients up to 70% of the wounds may not heal with standard care, there is a high demand for new solutions with better efficacy for the treatment of wounds. Cell therapies have emerged as promising therapeutic strategies to solve the problem of chronic wounds, but the limited engraftment and survival of the cells have restricted their efficacy in late stages of human trials. Exogenus is a spin-out company dedicated to develop a new therapeutic tool for the treatment of chronic wounds – Exo-Wound - which the company now seeks to clinically validate for diabetic ulcers. Exo-Wound is based on factors secreted by Umbilical Cord Blood (UCB) cells which accelerate the healing of skin wounds through promotion of vascularisation and stimulation of skin growth. Results from the animal models reveal important improvements in the healing capacity, treatment duration and biocompatibility when compared to competition. Nevertheless, in order to secure swift product development and successful commercialisation Exogenus is in need of partnerships and capital to overcome the classic ”Valley of death” gap. We believe the SME instrument is the ideal funding vehicle for us to establish Exo-Wound clinical validation and undertake the necessary activities to demonstrate safety and efficacy of the product in humans, and eventually achieve successful, global commercialization. The project will contribute to place Exogenus in a competitive position within the advanced wound care market and assist Europe in maintaining its competitive position in the fast growing segment of active therapies. The accomplishment of the project objectives will lead to a significant business opportunity for Exogenus, and generate revenues of around €30 million, five years after market entrance.

Keywords: chronic wounds therapy,advanced wound care products,active therapies,exosomes
Brains and minds in transition: The dark side of neuroplasticity during sensitive life phases (BRAINMINT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Norway
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1446113.0
EU funding (EUR): 1446113.0
Participants: 2
Project status: SIGNED

The potential and boundaries of the human mind is determined by dynamic interactions between the environment and the individual genetic architecture. However, despite several breakthroughs, the genetic revolution has not provided a coherent account of the development of the mind and its disorders, and the missing heritability is large across human traits. One explanation of this impasse is the complexity of the gene-environment interactions. Current knowledge about the determinants of a healthy mind is largely based on studies whose modus operandi is to treat the environment as a static entity, neglecting to consider the crucial fact that environmental inputs and their genetic interactions vary dramatically between life phases. The objective of BRAINMINT is to provide this missing link by zeroing in on two major life transitions, namely adolescence and pregnancy. These phases are characterized by temporarily increased brain plasticity, offering windows for adaptation and growth, but also host the emergence of common mental disorders. I propose that a multi-level investigation with this dark side of brain plasticity as the axis mundi will add a mechanistic understanding of this link between growth and vulnerability. I will test the main hypothesis that mechanisms that boost neuroplasticity promote adaptation to a dynamic environment, but at the cost of increased risk of psychopathology if exposed to a combination of genetic and environmental triggers. To this end I will utilize cutting-edge longitudinal brain imaging, electrophysiology, rich cognitive and clinical data, immune markers, gene expression and genetics. I will leverage on massive imaging data (n>40,000) and novel tools to increase power and generalizability and improve brain- and gene-based predictions of complex traits. Aiming to help resolving one of the modern day enigmas, BRAINMINT is a pioneering and high risk/high gain effort to find mechanisms of brain plasticity that support and harm the brain.
JIHAD OR RE-INTEGRATION: PATHWAYS OF FOREIGN FIGHTERS AFTER WAR (MPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Foreign fighters pose a serious threat to Europe. Western intelligence agencies believe that approximately 400 foreign fighters have returned to the EU from Syria and Iraq, and that at least 250 radicalized individuals have been smuggled to Europe from 2014 until 2016. The major hotbeds of foreign fighters smuggling and recruitment are located in Europe itself, in Bosnia and Kosovo, both of which underwent civil wars that featured foreign fighters. We know little about how foreign fighters behave in the aftermath of such civil wars: why some continue fighting in other wars while others go back to civilian life. This is an unfortunate shortcoming because numerous studies have shown that some foreign fighters have demobilized in the aftermath of wars in Afghanistan and Bosnia, while others left for Chechnya, Iraq and Syria to continue jihad. Those who continued fighting built networks with terrorists who are responsible for recent attacks in Europe. It is, therefore, imperative to understand these dynamics in order to make sound decisions that can prevent terrorism in Europe. This project will remedy this shortcoming by pursuing three goals. First, the project will adopt a fresh theoretical framework for the study of foreign fighters. Drawing on organizational theory, career transition and political violence literature, the project aims to explain post-war pathways of foreign fighters as a function of their role in previous war(s). Such an approach goes beyond standard focus on motivations and will help elicit why foreign fighters demobilize or turn violent in a long-term perspective. Second, the project will obtain new empirical insights into how foreign fighters pursued different paths in two similar, post-conflict contexts (Bosnia-Herzegovina and Kosovo). The third objective of the project is to develop a set of policy recommendations that will assist future policy makers in dealing with returning foreign fighters.

Keywords: terrorism,foreign fighters,re integration,postwar,bosnia herzegovina,kosovo
Enhanced Time as a Service: transforming telecom networks into a 'SuperGPS' system (OPNT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Netherlands
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Many technologies used daily to work, communicate or travel are based on networks of synchronized devices that require a timing source to operate. GNSS is the usual clock source for them but it is an insecure system with no backup. Moreover, the accuracy of GNSS clocks are not enough for the groundbreaking technologies as 5G or those related with space research. The GNSS market, with €120B revenue and expected to grow to €195B by 2025, comprises services as road navigation, location based services, automated driving, smart cities and IoT. Future 5G will also be part of it as depending on accurate timing for a correct performance. OPNT aims to relocate timing and positioning services, currently provided by satellites, as a ‘Timing as a service’ (eTaaS) available for the telecom network. eTaaS, developed at CERN, consists of a set of devices that, installed on an optic fiber network, connects a grandmaster clock with any element of the network that needs synchronization. It can offer more accuracy than GNSS and enable clock synchronization over 1000 km, thanks to the hardware and software developed by OPNT from the idea of the calibration of the off-set between two light beams of distinct colour traveling through an optic fiber circuit. OPNT’s technology, will offer to MNOs an alternative to GNSS timing in the form of low-cost devices that can be connected next to their existing base stations so the mobile network can be upgraded to 4G or 5G with no need of big investments. Thus MNOs can increase their wireless capacity and enable new business models based on time provisioning and accurate localization services. Timing (and later also location) as a Service will be offered at first stage with the hardware sale and at second stage with the provision of the service without the need of any hardware (just operate a fiber optic network). The project will be profitable with ROI=72 and cumulated revenue of €96.7M after 5 years of commercialization of eTaaS.

Keywords: time synchronization,optical fibre network,positioning services,telecomunications operators,earth based alternative to gps,extreme accuracy