Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Super-resolution quantitative imaging of HIV fusion and its neutralisation by antibodies (FILM-HIV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Seeing is believing. Under that premise, optical microscopy has become one of the most prominent observation technologies in life sciences. However, the spatial resolution of conventional optical microscopes is limited to around 250 nm. This raises the question on how we can apply this technique to the study the human immunodeficiency virus (HIV), a 120 nm large particle that is responsible for 1 million deaths every year. It seemed impossible, since the spatial resolution limit is caused by the diffraction of light and therefore a fundamental physical barrier. However, the development of super-resolution (sub-diffraction) fluorescence microscopy techniques, an emerging field awarded with the 2014 Nobel Prize in Chemistry, is providing new tools that are awakening optical microscopy-based virus research. My proposed project FILM-HIV (Fluorescence Imaging & Live Microscopy of HIV) aims to apply state-of-the-art advanced super-resolution microscopy techniques to monitor and study (i) viral cell entry, and (ii) the action mechanism of potent anti-HIV antibodies that are able to block this process. I, Pablo Carravilla, have chosen the Leibniz Institute of Photonic Technology in Jena, Germany, as my host institution to develop my project under the supervision of the renowned scientist Prof. Christian Eggeling, where I will be trained in highly advanced super-resolution microscopy and plasma membrane organization studies. As part of my research I will carry out a secondment at one of the best university biomedical institutions in Europe - the Medical Sciences Division of the University of Oxford. The acquired skills in combination with my knowledge on HIV, viral membranes and antibodies, will allow for a cutting-edge study of a process that is critical to the infection cycle of HIV, the causative agent of the most lethal pandemic of our times: the acquired immunodeficiency syndrome.

Keywords: super resolution fluorescence imaging,quantitative microscopy,membrane fusion
Mechanical regulation of cell migration by Piezo1 and its implications in epithelial cell turnover (PROMIGREX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Cancers arise in cell types that turnover by proliferation and death at highest rates, likely because these rates become unbalanced. Our group found that mechanical forces control both processes in epithelia: stretch activates proliferation whereas crowding activates cell extrusion and death. However, it was unclear what causes crowding and stretching forces in epithelia. I will investigate if cell migration from sites of proliferation drives the conveyor belt forces that control stretch-induced cell division and crowding-induced death. If so, the rate of cell migration could drive the rate of cell turnover and, hence, the propensity for a tissue to become cancerous. While my host lab has already identified roles for the stretch- activated ion channel Piezo1 in controlling proliferation and extrusion, based on preliminary compelling findings, I will determine if it also controls cell migration from sites of division. To do so, I will use established models in cell culture and mouse gut and develop an in vivo zebrafish gut model for homeostatic epithelial cell turnover. Additionally, I will test if frequent Piezo1 mutations in colon cancer impact cell proliferation, migration, and death. If my hypothesis is correct, I will reveal a new, unexpected role for cell migration in not only normal epithelial cell turnover but also in carcinogenesis. Should Piezo1 act as a central transducer of mechano-chemical coupling, it could provide a new target for therapeutics.

Keywords: calcium,mechanics,piezo1,mdck,zebrafish,migration,division,polarity,extrusion
Researchers for Humanity 2020 (R4H2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-01-31
Duration (months): 8.0
Total project cost (EUR): 112225.0
EU funding (EUR): 112225.0
Participants: 1
Project status: CLOSED

Continuing the series of events from 2007 organized in Romania, “Researchers for Humanity 2020” will build a strong link between public and research by stating the main message that science and researchers are useful for daily life and humanity over all, and their life is as everyone else’s. For one day (or 2 days in some places), the public will have the chance to meet important players from science and education through play, interesting talks and interactive hands-on learning. Based on the outstanding awareness of the European dimension of the event that we created throughout the years, European Researchers Night 2020 will confirm as being one of the most important communication event for research and education institutions. After last 2 years of enlarging the network (21 big, medium and small cities from all over Romania), this time we will focus on strengthening and increasing the quality of the interactions by gathering over 400 researchers, students and teachers in order to reach 45 000 visitors and over 650 000 persons exposed to the awareness campaign. The traditional logo of the event will be maintained so that a coherent link will be created with the European and national dimension of the event. Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level. Due to the long lasting relationships, the partnerships will be continued with main actors from mass-media, private research, universities and non-formal education institutions.

Keywords: science,researchers,science fun,learning,caravan,youngsters,research
Enabling the discovery of Earth's temporary satellite with the Large Survey of Space and Time (LSST-minimoon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Earth's minimoons are a transient population of asteroids which occasionally become gravitationally bound to the Earth for a limited period of time. Their physical characterisation on a population level can lead to a thorough assessment of the population of smallest asteroids, i.e., those with a diameter smaller than 20 metres. This little-studied population of asteroids is important, on the one hand, for resolving the fundamental asteroid-meteorite linking problem, with implication for the formation of the solar system, and on the other hand, are a constant source of local scale threat to Earth’s biosphere. Due to their easy accessibility by spacecraft and the large amount of time that they spend in the vicinity of the Earth, minimoons are good targets for asteroid in situ resource utilisation, or for space missions that could retrieve an entire asteroid to Earth for laboratory analysis. The primary aim of this project is to build a dedicated tool to extract the possible minimoon detections from the data stream of the upcoming Large Survey of Space in Time (LSST), which will be the only facility able to detect minimoons on a bimonthly basis. However, even for LSST, minimoons will be on the edge of its detection capabilities since the general solar system processing tools are designed for a general case of moving objects. Minimoons, due to their exceptionally rapid movement and narrow windows of detectability require special attention. Outputs will include a peer-reviewed article, and a software package to enable the discovery of minimoons on an order of magnitude greater scale than with the standard LSST processing tools. In line with Marie Sklodowska-Curie Action objectives, the project will enable transfer of knowledge and interdisciplinary skills of mutual benefit between the applicant and the host organisation, enhance the contact networks of both, and strengthen the future career opportunities of the applicant through establishing international collaborations.

Keywords: small solar system bodies,asteroids,temporary moons,near earth asteroids,astronomical software
CO2 Geological Pilots in Strategic Territories - PilotSTRATEGY (PilotSTRATEGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Greece,Greece,Poland,France,France,France,France,France,United Kingdom,Portugal,Portugal
Call: Geological Storage Pilots (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 10022547.5
EU funding (EUR): 10022547.5
Participants: 20
Project status: SIGNED

PilotSTRATEGY focuses on advancing understanding of deep saline aquifer (DSA) resources for geological CO2 storage in five European industrial regions in Southern and Eastern Europe. DSAs have much promise and potential for CO2 storage, but despite their high potential storage capacity, they are not well studied. There is a need to increase confidence and maturity of understanding of these sites. PilotSTRATEGY will investigate DSA in detail in three regions of Southern Europe: Paris Basin (France), Lusitanian Basin (Portugal) and Ebro Basin (Spain). This will include acquisition of new data, detailed geo-characterisation, feasibility studies and preliminary design or pre-front end engineering and design studies. At the end of the project, the level of site characterisation in these three regions will be sufficient to allow a final investment decision to be made and for storage permitting and project approval to be obtained. In two further regions of Eastern Europe, West Macedonia (Greece) and Upper Silesia (Poland), PilotSTRATEGY will increase the maturity and confidence level of understanding of DSA storage resources, based on new available data, reprocessing of old data and new dynamic simulation studies. This will enable these regions to start planning to develop their storage resources. Recognising the social challenge of implementing geological CO2 storage, PilotSTRATEGY will take a systemic approach and analyse the factors that influence societal acceptance of storage sites, to develop methods for societal engagement. Regional stakeholders and the local public will be involved in developing recommendations and concepts as part of the pilot conceptualization and design. At the same time, PilotSTRATEGY will run a series of dialogues, “Talk with Authorities,” to support capacity building in local authorities and build policy makers’ awareness of geological CO2 storage, particularly the role of CCUS in just, net-zero transitions in all regions.

Keywords: geological storage,storage pilot,field characterization,dynamic storage capacities,risk framework,mmv plans,societal acceptance,stakeholder engagement,feed,southern and eastern europe
Ortho-positronium decay and the search for CP and CPT violation in leptonic sector (OPSVIO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Croatia
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 147463.68
EU funding (EUR): 147463.68
Participants: 1
Project status: CLOSED

In the nature, we observe disbalance between the matter and antimatter, which can be explained by requiring of CP symmetry breaking. This was already observed in the quark sector, but the level of violation was not enough to explain the matter-antimatter asymmetry. Recent experiment involving neutrino oscillations reported the indication of CP violation in the leptonic sector. Ortho-Positronium (spin 1), a purely leptonic system, has very well-defined C and P properties, what makes it suitable for probing the CP ant CPT symmetries by constructing angular correlations between the polarization direction of positronium spin and the momentum or the polarization vector one of 3 gammas. Any deviation of the angular correlation amplitudes from zero would indicate discovery of a new physics. Within this action we propose to perform high precision measurement of CP amplitude and improve the precision level for one order of magnitude compared to the state-of-art results. The data acquisition system will be based on fast pulse digitizers, what will increase the rate and the amount of collected data, but will also increase the complexity of the data analysis. Data collected in this measurement will also contain information on two CPT amplitudes. We will determine both, and one of them will be determined for the first time. Since no suitable polarimeter for annihilation gamma rays exists at the moment, we will study polarization sensitivity of a single-layer Compton polarimeter based on 8x8 GaGG(Ce) crystal array, which will be read out by a matching SiPM array.

Keywords: ortho positronium decay,cp violation,cpt violation,polarization measurement
Technology transfer of Remotely Piloted Aircraft Systems (RPAS) for the creative industry (AiRT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Spain,Belgium,United Kingdom
Call: Support technology transfer to the creative industries (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 1156725.0
EU funding (EUR): 914726.25
Participants: 4
Project status: CLOSED

Aerial photography and filming represent an indispensable resource for the Creative Industries (CIs). When filming in indoor environments, auxiliary devices as cable cams, camera rails, jibs, scaffolds or lifting platforms are being employed, enabling to realize special aerial camera shots. With the rise of Remotely Piloted Aircraft Systems (RPAS), commonly known as drones, CIs are increasingly focusing on its use outdoors, providing significant advantages over current photography and filming techniques such as widening the creative possibilities and freedom of camera movement, less invasive and risky compared to auxiliary devices and affordable. However, RPAS cannot be professionally employed indoors by the CIs. Existing RPAS lack of a precise, robust and affordable indoor positioning system (IPS) as well as advanced safety features. Without a good IPS the control of the RPAS in indoor environments is particularly difficult and even unsafe. Currently, there are three IPS suitable for RPAS, but these are too expensive (€200k), or present large limitations (e.g. sensitive to light conditions) for its usage by CI SMEs. This jeopardizes the creative possibilities of CI and their competitiveness. Hence, the main goal of AiRT project is to provide the European CI SMEs a tool that, by expanding their creative spaces will help them to offer new services, which in turn will increase their changes to grow within the European and international market. To accomplish this objective, AiRT project will develop the world´s first indoor RPAS specifically designed for professional use by the CIs. As a result, over 900.000 European CI firms will benefit from the transfer of the latest advances in IPS, 3D scene reconstruction, navigation and active / passive safety measures into an intelligent indoor RPAS, being able to avoid both static and dynamic objects. In addition AiRT system could be programmed in order to fly autonomously, enabling the CIs to focus on the camera control.

Keywords: rpas,indoor positioning systems,aerial filming photography,intelligent navigation,3d scene reconstruction,advanced safety measures
Solute carrier proteins and the uptake of cytotoxic approved drugs (DrugsUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

The transport of nutrients and metabolites across lipid membranes is a critical and essential biological process in both normal and pathological conditions. Specialized integral membrane proteins known as transporters are responsible for the movement of virtually any known class of biologically active molecules across membranes. Perhaps not surprisingly, there is increasing evidence that many drugs in clinical use also employ carried-mediated transport as the predominant entry method into the cell. Understanding the molecular and physiological basis of transporter-mediated drug uptake is therefore a key step toward the development of improved pharmacokinetics and models of toxicity for current and future therapeutically active compounds. We hypothesize that most approved drugs may require specific members of the solute carrier (SLC) family to cross the cell membrane, a phenomenon that would directly affect the compound activity, and that this process is basically underestimated in its importance. To test this hypothesis, the study proposed here aims at identifying SLC transporters involved in the uptake of a well-characterized set of commercialized drugs. The CeMM Library Of Unique Drugs (CLOUD) is a library of 300 compounds selected to be representative of the chemical space covered by all commercially available drugs. Human cell lines carrying deletions on specific SLC proteins will be tested for their ability to resist toxicity or challenges due to CLOUD compounds, allowing us to determine which transporter or family of transporters are involved in the uptake of specific drugs classes. The information derived from these studies will represent an important step forward toward a systematic characterization of the role of carrier-mediated transport in drug uptake.

Keywords: transporters,drugs,haploid genetics,crispr,cas9,toxicity screening
Easy-to-Implement Energy-Based Control Design for Systems of Conservation Laws (EasyEBC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-03-01
Duration (months): 12.0
Total project cost (EUR): 92538.0
EU funding (EUR): 92538.0
Participants: 1
Project status: CLOSED

Secure, clean and efficient energy as well as resource efficiency are major societal challenges formulated in the EU Horizon 2020 Framework Programme. Many subsystems in energy, production and process industries are systems of conservation laws and their efficient operation relies on precise modelling and feasible control design. The port-Hamiltonian approach, developed in a vibrant European research community with the project supervisor as one of the leading figures, uses energy as the key argument for modelling and control of interconnected, nonlinear multi-physics systems, including systems of conservation laws. The aim of EasyEBC is to develop easy-to-handle energy-based control design procedures for nonlinear systems of conservation laws in the port-Hamiltonian framework. Linear and nonlinear methods from mathematical control theory of finite- and infinite-dimensional systems will be applied for analysis and control synthesis, e.g. semi-group theory, discretization techniques, and energy shaping. The mathematics will be masked behind a user-friendly frontend that offers transparent tuning criteria for the closed-loop dynamics. Bridging the gap between mathematical complexity and easy applicability of the design tools is the main challenge of the project. The capacity of the renowned supervisor, the application examples at the secondment partners, such as chemical and thermodynamic processes or energy-efficient building refrigeration, and the fellow’s experience in applying nonlinear energy-based control are essential for the scientific success of the project. As a long-term impact, EasyEBC will contribute to making nonlinear model-based control more accessible to engineers beyond academia.

Keywords: port hamiltonian systems,distributed parameter systems,structure preserving discretization,control design automation,reduced state feedback control,energy shaping