Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultra-fast Antimicrobial Susceptibility Test for diagnosing antimicrobial resistance to provide personalized antibiotic treatments (Nanosynex)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Antimicrobial Resistance (AMR) has been declared as one of today’s biggest global threats as 700,000 people die due AMR. Inappropriate antibiotic use is widespread. In the general practice, physicians commonly use empirical antibiotic therapy (highly inaccurate), since AST results take too long. Nanosynex product provides a revolutionary ultra-fast AST technology that will disrupt the market by cutting time to results in more than half (from 9 – the fastest - to 4 hours). This will allow physicians to get same-day results (i.e., in less than 5 hours) for AST, a unique feature that will save at least one day of hospitalization per patient and help reducing the spread of resistant bacteria. A successful validation through this Phase-1 of the technology and our revenue models will be fundamental to demonstrate evidence of user satisfaction A successful validation through this Phase-1 of the technology and our revenue models will be fundamental to demonstrate evidence of user satisfaction. Nanosynex Ltd is an Israeli start-up providing health-care systems with a rapid microfluidic diagnostic solution for faster and personalised antibiotic treatment. The company intends to scale up in the European market first, thanks to its strategic partnership with Biosynex, a leading French rapid diagnostic test (RDT) company that has an established distribution network in Europe, Middle East and Africa (60+ countries). Afterwards, Nanosynex will expand internationally. Nanosynex forecast to generates 14.7M€ , and and at EBITDA of 3.4M€ by 2024

Keywords: antimicrobial resistance,antimicrobial susceptibility test,diagnostic
Staff Exchange for Novel applications in 19f magnetic resonance imaging (SENATOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Italy,Germany,Germany,Germany,Netherlands,Netherlands,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 1541000.0
EU funding (EUR): 1541000.0
Participants: 11
Project status: CLOSED

Magnetic resonance imaging (MRI) is a leading clinical diagnostic technique, which is able to provide whole body imaging, and when individual cells are imaged in living animals, it can provide new insights into the biology of cell trafficking and migration. For cells to be visualised by MRI, they generally must be labelled to enable their discrimination from surrounding tissue. The development of magnetic resonance imaging (MRI) contrast agents is therefore an active area of research, where the basis for this interest is the expansion of MRI as a high-resolution and non-invasive important preclinical and clinical imaging modality. Moreover, there are now new opportunities to developing smart materials with multifunctional abilities including MRI contrast in-built within biomaterial structures, functionalisation with targeting ligands and the carrying of a therapeutic payload. This move towards a new generation of MRI contrast reagents has also been spurred on by the mounting evidence against gadolinium-based contrast agents (GBCAs). They are currently the agents of choice and were considered historically safe and well tolerated until recently. However, they have been found to accumulate in various tissues of patients who do not have renal impairment, including bone, brain and kidneys. Furthermore, in 2015, the FDA released a new safety announcement regarding GBCAs and the risk of accumulated deposits in the brain following repeated use. Whilst GBCAs are being investigated, they can still be administered but healthcare professionals have been advised to limit the use of GBCA to situations in which contrast is deemed absolutely necessary.This has opened the door to the novelty of using perfluorocarbon (19F) being incorporated inside smart nanoparticles, which can offer unique quantitative signatures for molecular MRI with no competing background signal.

Keywords: magnetic resonance imaging,nanomaterials,perfluorocarbons
The Sign Hub: preserving, researching and fostering the linguistic, historical and cultural heritage of European Deaf signing communities with an integral resource (SIGN-HUB)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Israel,Spain,Türkiye,France,Netherlands
Call: Emergence and transmission of European cultural heritage and Europeanisation (H2020-REFLECTIVE-SOCIETY-2015, 2015)
Start date: 2016-04-01
End date: 2020-04-30
Duration (months): 49.0
Total project cost (EUR): 2518737.5
EU funding (EUR): 2499337.5
Participants: 11
Project status: CLOSED

SIGN-HUB aims to provide the first comprehensive response to the societal and scientific challenge resulting from generalized neglect of the cultural and linguistic identity of signing Deaf communities in Europe. It will provide an innovative and inclusive resource hub for the linguistic, historical and cultural documentation of the Deaf communities' heritage and for sign language assessment in clinical intervention and school settings. To this end, it will create an open state-of-the-art digital platform with customized accessible interfaces. The project will initially feed that platform with core content in the following domains, expandable in the future to other sign languages: (i) digital grammars of 6 sign languages, produced with a new online grammar writing tool; (ii) an interactive digital atlas of linguistic structures of the world's sign languages; (iii) online sign language assessment instruments for education and clinical intervention, and (iv) the first digital archive of life narratives by elderly signers, subtitled and partially annotated for linguistic properties. These components, made available for the first time through a centralized platform to specialists and to the general public, will (a) help explore and value the identity and the cultural, historical and linguistic assets of Deaf signing communities, (b) advance linguistic knowledge on the natural languages of the Deaf and (c) impact on the diagnosis of language deficits within these minorities. SIGN-HUB will thus contribute to the dissemination and reuse of those assets in broader contexts, as part of European identity. The project is a critical attempt to rescue, showcase and boost that largely unknown part of our common heritage, as well as to ultimately enhance the full participation of Deaf citizens in all spheres of public life on an equal footing with hearing citizens.

Keywords: deaf culture,sign language,deaf signing communities,linguistic minorities,grammar,language assessment,european linguistic heritage
People for tHe eurOpean bioENergy mIX (Phoenix)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Austria,Germany,Armenia,Romania,Belgium,Finland,Croatia,Belarus,France,Netherlands,Portugal,Portugal
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 1377000.0
EU funding (EUR): 1377000.0
Participants: 16
Project status: CLOSED

The development and adoption of renewable and sustainable forms of energy has become a major priority for Europe and is an important theme in H2020. Research into new, energy-related technologies to reduce Europe’s reliance on non-renewable fossil fuels is a critical need, and requires more newly qualified people in areas such as renewable-energy infrastructure management, new energy materials and methods, as well as smart buildings and transport. Bio-energy is particularly relevant to the Work Programme, because it is at the crossroads of several key European policies – from the Strategic Energy Technology Plan Roadmap on Education and Training (SET-Plan) to the European Bio-economy Strategy for European Food Safety and Nutrition Policy. So far, technological development has concentrated on using crops and wood for fuel, energy and industrial products. These conventional bio-resources are, however, limited, and the use of nonconventional, currently unused or under-utilised bio-resources provides the best possibility for the growth of the bioeconomy. However, European development in this priority field is failing to keep pace with demand due to a lack of qualified personnel, a lack of cohesion and integration among stakeholders, and poorly developed links between professional training and the real needs of industry. Based on seven work packages the Phoenix RISE project will address these issues by exploiting the complementary expertise of its partners and creating synergies between them through the targeted secondments of staff to advance research and innovation knowledge in bio-energy research. Phoenix is an international, interdisciplinary, cross-sectorial project, bringing together a total of 16 partners: 14 from the EU (5 companies and 9 academic organisations) and two Third-Country academic partners to enhance its collective research excellence and create new, post-graduate-level research training in key disciplines that support the provision of bio-energy.

Keywords: bio resource,bio energy,bio economy,value chains,bio fuels,bio refineries,grid integration,thermal biomass utilisation,training,inter sector,renewable,sustainable
Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics. (RNAct)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Italy,Germany,Spain,Belgium,Sweden,Lithuania,Belgium,France,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 2614996.8
EU funding (EUR): 2614996.8
Participants: 14
Project status: CLOSED

RNAct creates an integrated and multidisciplinary training and research programme for 10 broadly employable ESRs with versatile computational and experimental skills. The RNAct research aim is the design of novel RNA recognition motif (RRM) proteins for exploitation in synthetic biology and bio-analytics. This is achieved through a design cycle that starts with computational approaches at the sequence and structure levels of proteins and RNA, in order to select amino acid positions and mutations for large-scale phage display experiments with RNA screening. Viable RRMs will be further investigated at the atomic level with integrative structural biology approaches, and will be applied in synthetic biology, to post-transcriptionally regulate fatty acid processing via RRMs, and in bio-analytics, to detect RNA in-cell and design RNA biochips. The RNAct training will provide ESR-tailored research and education-based training in both topical content and transversal skills. All ESRs will experience both academic and industrial environments, and will be exposed to both computation and experiment at the peer level via an ESR 'buddy' system. The ESRs will be actively involved in, and responsible for, information dissemination and communication for the RNAct project, and will have to opportunity to participate in innovation activities. This will enable the ESRs to constructively contribute to the European bio-economy in both academic and industrial settings.

Keywords: synthetic biology,bio analytics,protein design
The Discovery of Pleasure. Female Sexuality and Value Change in West Germany and Italy in the Long Seventies (FEM1970)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-20
End date: 2019-04-19
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Discussion of female sexuality in the West during the 1900s was usually centred on the aspects of maternity and reproduction. As the liberalisation narrative in recent historiography has argued, female sexuality ceased to be tied to procreation and marriage sometime during the second half of the 20th century, partly due to the affirmation of a new form of sexuality more oriented towards experimentation and self fulfilment. Female erotic experience started to be valued in itself and to serve the individualisation of women. This development needs to be integrated with the theory of an unprecedented change in values in industrialised Western Europe towards post-materialism and individualism (Ronald Inglehart et al.). My project will explore the transformation of female sexuality in West Germany and Italy from the 1970s onwards. It aims to reconstruct the shifts in public morality, social practices, and value changes in these two West European countries. It questions whether the development of values and sexuality in these countries was post-materialist and individualistic in nature. Other European examples will be considered as valuable references. An experience in the British academic system represents an opportunity for expanding my professional competence in terms of historiographic skills and for developing new academic contacts, which I consider very important for the positive development of my career.

Keywords: sexuality,value change,transformation,individualisation,identity
Industrial electrolyser for large-scale on-site renewable hydrogen production for manufacturing industry (HyLYZER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently, Europe is undergoing the first stages of an enormous energy transition looking to decarbonize industrial processes, driven by the binding agreements reached at the COP21 meeting in Paris in 2015 to stop global warming. This new energy paradigm will require a major contribution from renewable hydrogen to be successful. Industries such as steel making, fertilizer production, chemical and petrochemical refining or glass making, already use hydrogen as feedstock or high heat for various ends. However, most of the production processes involve carbon-based energy sources and are highly polluting, contributing abundantly to global GHG emissions. Overall, industry was responsible of over 25% of the GHG emissions in Europe in 2015. The use of renewable hydrogen could reduce 20% of global CO2 emissions by 2050. In Hydrogenics, we have developed HyLYZER, an innovative industrial scale electrolyser, based on PEM (Proton Exchange Membrane) technology, that generates on-site clean high purity hydrogen with zero-emissions from renewable energy sources at unmatched efficiency: 85% average at stack level. Our solution's impact in the reduction of GHG emission can be quantified as 1ton of H2 abating 10tons of CO2. We are a global leader provider of hydrogen solutions, with several market products for various ends and a solid reputation in the H2 industry. We have invested 19years of R&D in PEM electrolysis to develop HyLYZER. We aim to carry out a Feasibility Study to plan the best commercial strategy for our project and plan the industrial scale-up required to increase production from demo plant to commercial sales, as well as to confirm the alignment of our project, HyLYZER, with the market needs through strategic partnerships. In five years from project completion, we expect that Hydrogenics HyLYZER project brings us a Return of Investment of €4,56 per euro invested in this project.

Keywords: hydrogen generation,industrial feedstock,renewable hydrogen,clean energy,efficient energy
Transforming distributed energy generation through the FUTURe Gas TurBINE (FUTURBINE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 3273000.0
EU funding (EUR): 2291100.0
Participants: 2
Project status: CLOSED

Futurbine aims to commercialise Aurelia A400 v2.0, the world’s most efficient small turbine for combined heat and power (CHP) generation. It is a highly innovative 400 kW gas turbine with 40.2% electric efficiency, offering the most efficient solution in the market for small-scale process and SME industry. In Europe it would result in potential annual energy savings of €18 bn. Small-scale process and SME factories are a key part of Europe’s economy and employment, with over 20 million companies, such as dairies,breweries, and small chemical and building materials factories. Typically located in small towns or remote areas, they consume over 20% of the total energy in the EU. Currently there is no economically feasible decentralised solution in the market for their capacity range (less than 2, 000 kW) and need for high-temperature steam, so 90% of these SME factories use inefficient energy systems with high emissions. A400 fills this market gap Our innovative, patented technology, which uses two shafts and reheatable exhaust gas, brings many benefits: 1) the best solution for steam-CHP below 2 MW; 2) the highest available electrical efficiency of 40.2%; 3) low emissions, even below EU requirements; 4) wide range of fuels (synthetic and bio, liquid and gas); 5) minimal downtime due to low maintenance and lack of lubricants; 6) zero vibrations; and 7) high economic profitability. We will bring the ground-breaking potential of our technology first to small-scale process industry, and, as the technology is easily scalable to larger energy ranges, then to other CHP markets, which are expected to be 2/3 of new electricity capacity by 2030. In addition, we have developed an innovative distributed integrator partner model, which creates new local jobs and skills in several EU countries through technology transfer. After Phase 2 project we expect to commercialize A400 v 2.0 and reach payback by 2nd year after Ph2 with cumulative profit of €30.6 M and ROI of 514% by 2025.

Keywords: combined heat and power generation,decentralised energy,micro gas turbine
Exploring Thermodynamic Properties of Earth’s Core-Forming Materials (Earth core)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2021-09-30
Duration (months): 76.0
Total project cost (EUR): 1891765.0
EU funding (EUR): 1891765.0
Participants: 1
Project status: CLOSED

It is known that the Earth’s core is less dense than pure iron by about 7%, which is due to the presence of a light element(s) such as Si, S, C, O, and H. The goal of this project is to construct a thermodynamic model of the Earth’s central core. A particular focus is on the identification of the light element because the inclusion of these elements in iron liquid depends on the pressure (P), temperature (T), and chemical environment and hence provides us invaluable information about the origin and evolution of the solid Earth. We will examine phase relations and density of phases in Fe-light element systems by conducting high-P-T experiments and employing thermodynamic calculations based on the experimental data. High-P-T experiments will be conducted in a diamond anvil cell with three different kinds of heating techniques: laser heating, external-resistive heating, and internal-resistive heating. Of the three, the internal-resistive heating system is a special technique that I have developed and employed and I am currently generating 5000 K at 200 GPa with it. Structure of phases will be analysed by in-situ X-ray diffraction. Chemical analysis will also be employed on samples to determine element partitioning between the phases. I will also employ thermodynamic calculations based on the experimental data to fully understand the thermodynamic properties of the materials and obtain physical properties which are difficult to directly determine by experiment such as sound velocity of liquids. From the thermodynamic models, I will calculate the physical properties of light element-bearing iron liquids and compare them with seismologically constrained values of the Earth’s core to find out the best matching composition. From these results, I will discuss the physical and chemical environments during the core formation and implicate in the origin and evolution of the Earth. Also the results will be applied to other terrestrial planets which have metallic cores.