Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Highly Integrated Versatile Laser Source enabling two-photon excitation in digital diagnostics and biomedical research (HILIGHT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: France,United Kingdom,Germany,Italy,Switzerland
Call: Versatile light sources and systems as tools for manufacturing and medical application (Photonics Partnership) (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3567008.11
EU funding (EUR): 3185792.64
Participants: 5
Project status: SIGNED

The overall objective of HILIGHT is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around two-photon excitation fluorescence lifetime measurements and imaging microscopy. We propose two specific use cases: i) instantaneous digital histopathology and ii) biomedical research in the context of cancer research and diagnostics. HILIGHT proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in SoA instrumentation that often confine the use of two-photon microscopy and time-resolved detection to the specialist laboratory. We envisage that the HILIGHT innovations could disrupt activities in various fields and a range of market segments, including academic and research institutions, biotechnology, and medical facilities. These include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo, ex vivo, or 3D organotypic cultures, with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions. HILIGHT is structured around nine work packages covering the whole value chain, coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains. HILIGHT consortium is made up of five leading partners from various fields experienced in European collaborative projects and from five different European countries (FR, DE, IT, CH and UK). HILIGHT is built on several prior and ongoing successful collaborations between partners, which provides a strong guarantee for successful interaction within the consortium, and a smooth implementation of the workplan.

Keywords: two photon excitation,fluorescence lifetime imaging microscopy,digital histopathology,confocal microscopy,single photon avalanche diode,biochemical imaging,non linear microscopy,optogenetics
Accelerated Cell- and Battery Testing (AccCellBaT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Austria,France,Germany,Italy
Call: Digitalisation of battery testing, from cell to system level, including lifetime assessment (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 4980428.75
EU funding (EUR): 4980428.75
Participants: 11
Project status: SIGNED

Today’s battery development is impeded by a lack of virtualization, resulting in cost-and time-intensive physical verification and validation (V&V) activities. AccCellBaT addresses these shortcomings by substantially advancing virtualization, front-loading, and continuous V&V in future technology battery development to optimize battery design, cost, and time-to-market. Focusing on beyond state-of-the-art cell chemistry, novel physics-based and data-driven simulation models are developed to determine performance, lifetime, reliability, and safety of battery sub-systems. To ensure model applicability and high confidence, these models are accompanied by novel in-live model parameter measurement techniques, and by upscaling methods to scale cell models up to battery system models. Models and measurement data are synthesized to digital twins to be utilized in V&V. To advance front-loading, tests of these digital twins are merged with physical tests in a novel hybrid design verification and validation plan (hybrid DVP) methodology. To objectively quantify and ensure the confidence of test results, a tailored confi-dence index methodology for approval of the hybrid DVP is introduced. Based on Systems Engineering principles, processes and methods currently used by AccCellBaT consortium members are combined with the hybrid DVP and optimized to create a process-and-method manual applicable for future battery development. These building blocks of the full AccCellBaT methodology are implemented in a development tool, which provides an inte-grated development environment for management, planning and execution of battery V&V. The tool supports practitioners in development and significantly increases the level of process automation.To ensure validity and applicability of the AccCellBaT methodology across industries, the methodology is validated by two original equipment manufacturers (representing via automotive and stationary application a crucial share on battery system market).

Keywords: accelerated development,digital twin,integrated data platform,novel cell chemistry,advanced battery modelling,validation and verification,simulation,automotive,stationary storage
The Political Culture of Post-imperial Intervention. The case of Spain and the South American republics of the Pacific (1833-1868). (POST-EMPIRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-16
End date: 2026-09-15
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: TERMINATED

The project POST-EMPIRE will analyse the ideas and cultural representations that shaped the interventionist foreign policy deployed by the Spanish Monarchy in the republics of Chile, Peru and Ecuador during the Elizabethan period (1833-1868). I will reconstruct the doctrinal developments of pan-Hispanism, free trade imperialism, (anti)republicanism and navalism to understand how they structured the political culture of post-imperial interventionism, legitimising and guiding Spain's attempts to establish a sphere of influence in its former possessions. By studying a little-considered example of post-imperial interventionism, I aim to stimulate discussions at the academic and media levels that allow comparison with other analogous cases. POST-EMPIRE will achieve the following Research Objectives: RO.1: To explain the geopolitical imaginaries that gave rise to Spanish post-imperial interventionism. RO.2: Assess the weight that the examples of the British Empire, France and the United States had in the strategic culture of informal Spanish imperialism. RO. 3: To gain access to an interdisciplinary training experience that will allow me to enrich my knowledge as a historian of European-American relations with the perspectives of trans-Pacific historiography, political theory and socio-constructivist international relations theory. RO. 4: To contribute to elaborating an interdisciplinary theorisation of the dynamics that have characterised post-imperial conflicts throughout contemporary history. RO. 5: To enrich general social knowledge about the dynamics that govern post-imperial conflicts, seeking to raise awareness among public decision-makers and civil society of their importance for the Strategic Compass for the EU and European Security and foreign policy.

Keywords: informal imperialism interventionism spain latin america pacific transatlantic imaginaries post imperial conflicts
In vivo genetic screen in xenotransplanted cord blood-derived macrophages to identify regulators of human border-associated macrophage identities (inviXTus-BAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Border-associated macrophages (BAMs) are macrophages that reside in specific anatomical interfaces between the brain and the blood circulation. Due to limited access to fresh human tissues from those anatomical sites, our understanding of human BAM development and function remains poor. It was previously observed that human hematopoietic stem cells from umbilical cord blood take up residence and differentiate into BAM-like macrophages when injected into the brains of neonatal mice expressing human colony-stimulating factor 1 (hCSF1). Single-cell RNA-sequencing confirmed strikingly similar transcriptomic signatures of those human macrophages to BAMs. The resulting chimeric mouse model represents an innovative platform in which the development and function of human BAMs could be investigated. In the current study, brain-xenotransplanted human cord blood-derived macrophages will be further characterized to assess whether they show location-specific molecular signatures, as do human BAMs. Then, an in vivo CRISPR knockout screen will be performed on those cells in order to decipher the genetic regulators of human BAM identities. I, the applicant, have extensive experience in brain immunology and in working with macrophages. I will work on developing and applying an in vivo CRISPR screen workflow in the chimeric mouse model developed by the laboratory of Dr. Movahedi (VUB, Belgium) who has established himself as a leader in brain macrophage research. This project will offer me the invaluable opportunity to learn genome editing techniques, design and execution of mouse experiments, as well as single-cell -omic experiments using state-of-the-art instrument. By bridging my existing knowledge with the cutting-edge techniques offered at the host laboratory, I aim to lay the foundations for an innovative system to study human BAMs.

Keywords: macrophage,brain,neuroimmunology,crispr,neuroscience,inflammation
The Quest for MAGNetIc Fields in A and F TYpe Stars (MAGNIFY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999933.0
EU funding (EUR): 1999933.0
Participants: 1
Project status: SIGNED

Magnetic fields are ubiquitous and have a substantial impact on galactic, stellar and planetary evolution and on life. Theoretical models imply that magnetic fields can affect stars from the deep interior to the outermost layers at each stage of evolution. Yet the origin, geometry and evolution of magnetic fields often remain a mystery. Consequently, standard stellar evolution models do not consider the interaction of magnetic fields with other physical processes. Extensive surveys show that only 10% of the intermediate-mass A&F-type main-sequence stars have detectable magnetic fields. However, studies show that up to 60% of red giant stars that evolve from these stars have strong internal magnetic fields. Stellar evolution dictates that if the magnetic fields exist in these red giants, they must also exist in younger stars. This discrepancy raises many open questions: Have surface magnetic fields in A&F stars been below the detection threshold of modern instruments? Are their magnetic fields confined to stellar interiors and never penetrate the surface? If so, how may we detect them? Are there physical processes that prevent A and F stars from producing and maintaining stable magnetic fields? MAGNIFY aims at answering these questions by 1) investigating the existence of internal and surface magnetic fields in A&F stars using asteroseismology and 2) exploring the mechanisms producing magnetic fields by studying stellar spots. With asteroseismology, we can use stellar pulsations to probe deep into the stellar interior to detect the presence of hidden magnetic fields. We will use data from the Kepler, TESS and Gaia space missions to study A&F type pulsators and use stellar evolution and pulsation models to disentangle the signatures of magnetic fields from other physical processes. Finally, we will use measurements of stellar spots in a large number of A&F stars to broaden our understanding of magnetic field generation and how it varies with stellar mass and age.

Keywords: asteroseismology,magnetic fields,intermediate mass stars,stellar spots
Electro-conductive polymeric 3D scaffolds as novel strategies for biomedical applications (ESCULAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Latvia,Ukraine,Finland,Poland,France,Lithuania,Portugal,Czechia,Brazil,Canada,United States
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 1677028.57
EU funding (EUR): 1444400.0
Participants: 13
Project status: SIGNED

ESCULAPE project is targeted to building a strong interdisciplinary partnership in order to support joint research and innovative activities in the fields of biomaterials, polymer science, nanotechnology, tissue engineering, microbiology and medicine with the aim to explore development and implementation of new medical engineering solutions for regenerative medicine and wearable electronics. The project will offer novel solutions (from the manufacturing stage to exploitation strategies) using MXenes, a new class of two dimensional (2D) materials consisting of transition metal carbides/carbonitrides. MXenes will be employed to modify properties and qualities of porous 3D electrospun nanoscaffolds, which will be used in tissue engineering for regenerative biomedicine and development of wearable electronics on both woven and non-woven fabrics. The main goal of the ESCULAPE project is to build a new training partnership to develop innovative strategies to achieve advanced biomaterials with target-oriented properties (electrical conductivity, biocompatibility etc.) that will be able to deliver specific features for regeneration of heart and nerve tissues, regulation of homeostasis in iPSCs, as well as in development of wearable electronics. Interdisciplinary and inter-sectoral secondments will be the main tool for project realization with the aim of strengthening research, training, communication and networking capacities of participant organizations and knowledge transfer from academia to industry and vice versa. Proposed research and training goals will lead to enhance research and transferable skills of the ESRs, as well as their competences with the aim of improving competitive employability and career prospects in both academic and industrial sectors. Public dissemination of new research results will increase the awareness of general society on the role of researchers and research infrastructure in establishing the EU as a world leading R&I force.

Keywords: mxene,electrospinning,conductive biomaterials,tissue regeneration,organ on chip,wearable electronics
Cure Diabetes by Injection of Micro Pancreas Cell Therapy II (MP II)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Betalin plans to disrupt diabetes therapeutics with the introduction of a biological Micro Pancreas (MP) to be implanted as a cure for insulin-dependent diabetic patients. This innovative initiative involves the integration of tissue engineering and cell therapy technologies, with the overarching objective of restoring insulin production for the growing population of diabetes patients worldwide. The Micro-Pancreas, at its core, is a biological tissue-derived scaffold that is meticulously populated with insulin-secreting β cells derived from human stem cells. Upon implantation in diabetic patients, this construct is designed to reinstate the regulated insulin secretion that has been compromised due to the destruction of the patient's endogenous pancreatic islets. The biological tissue-derived scaffold is designed to significantly reduce the number of required stem cells (or islets) for normalizing blood glucose levels using islet transplantation (Edmonton protocol) or stem cell-derived β cells transplantation. The advent of Betalin’s groundbreaking technology is timely, with its readiness for scale-up supported by our preclinical studies. The project is poised to advance to the regulatory approval phase for clinical studies. Additionally, apart from its capacity to transform the diabetes treatment landscape, Betalin's technology holds the promise of serving as a versatile platform that could support cells from different organs. MP II presents a novel opportunity for the development of cell therapy solutions targeting complex diseases and their respective markets.

Keywords: diabetes therapeutics,pancreas
All-in-one surface methodology for corrosion protection in Metal Additive Manufacturing (SuMAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Metal Additive Manufacturing (MAM), also known as 3D metal printing, has attracted a great deal of attention from scientists and industries due to its potential in the state-of-the-art production of complex-shaped designs in the transport industry. MAM is considered the fundamental technology for Industry 4.0 since it is a low-cost and energy-efficient processing method for metallic components with a minimal environmental impact. Nevertheless, the surface finishing of MAM components is uncontrolled during the fabrication, resulting in low corrosion-resistant components. So far, current post-surface treatments are non-eco-friendly, non-energy efficient, and the achieved corrosion resistance does not fulfil the service life requirements. In this scenario, the main goal of the SuMAM project is to achieve the full exploitation of MAM in the transport industry following the European Green Deal. Namely, as a major innovation, we will develop an innovative All-in-one methodology to achieve the highest corrosion resistance during printing, removing the need for post-treatment. We will combine two approaches: surface creating by (i) in-situ laser processing and (ii) incorporation of additives during printing to control the surface without affecting the bulk properties of the final components. Our target materials are four aluminium alloys and one stainless steel, widely used materials in the transport industry. This project is an outstanding opportunity for the fundamental advancement of MAM science by a technological and economically feasible methodology. The SuMAM project presents the best research scenario for Dr. Rubén Del Olmo Martínez (candidate) to further develop his scientific career. The SuMAM project is led by Prof. Dr. Ir. Iris de Graeve and Prof. Dr. Ir. Herman Terryn from the SURF research group of the Vrije Universiteit Brussel (VUB), with a proven outstanding track record in both academic and industrial sectors in the scope of the proposal.

Keywords: metal additive manufacturing aluminium alloys stainless steel corrosion behaviour microstructure corrosion protection electrochemical analysis surface chemistry
Quantum simulation of far-from-equilibrium gauge theories (QuSiGauge)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498369.0
EU funding (EUR): 1498369.0
Participants: 2
Project status: SIGNED

Gauge theories (GT) are the staple of the Standard Model, and their far-from-equilibrium dynamics opens a window into the most fundamental questions of high-energy physics (HEP) and the nature of equilibration in isolated quantum many-body systems. However, this dynamics is often highly nonperturbative and difficult to probe using classical methods due to entanglement buildup. Through quantum advantage and tunability, quantum simulators (QS) emerge as a particularly suitable venue to solve this problem. QuSiGauge hinges on developing an overarching framework composed of two main interconnected pillars: a technological one focused on designing robust tunable experimentally feasible QS of GT, and a phenomenological one concerned with a rigorous formulation of far-from-equilibrium quantum criticality and equilibration in isolated many-body models. The project will focus on the quantum simulation of (non-)Abelian GT, qudit quantum computing for HEP, non-ergodic dynamics of GT, and extracting far-from-equilibrium quantum critical exponents from dynamical phase transitions in GT. The approach is organized such that it provides both basic intuition and formal understanding, while emphasizing quantitative predictions accessible to state-of-the-art and near-term QS. QuSiGauge will pave at least two solid paths to uncover new physics: (1) It will provide a toolbox for probing engineered exotic GT and gauge-noninvariant dynamics not easily accessible to particle colliders, yielding tunable platforms for investigating the equilibration of controlled isolated many-body models. (2) It will advance QS towards the holy grail of making them a reliable complementary venue for exploring collider-relevant physics. QuSiGauge will be of immediate impact to current cold-atom and ion-trap experiments, which are approaching quantum advantage, and will reach far beyond its immediate field, eliciting strong connections between condensed matter, HEP, and quantum simulation/computing.

Keywords: quantum simulation,lattice gauge theories,far from equilibrium dynamics,dynamical quantum phase transitions