Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory Central Nervous System lesion size and severity through Gas1 co-receptor modulation. (EFHHBBBMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-15
End date: 2021-01-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of "young leader in neurovascular biology" with an international collaborative network.

Keywords: blood brain barrier,hedgehog signaling,multiple sclerosis
Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine (TranSYS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Spain,Germany,Germany,Slovenia,Belgium,France,Netherlands,Netherlands,Luxembourg,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-09-01
End date: 2024-05-31
Duration (months): 57.0
Total project cost (EUR): 3916285.67
EU funding (EUR): 3916285.67
Participants: 13
Project status: SIGNED

TranSYS will recruit 15 ESRs to highly skilled jobs in the new area of Systems Health developing tools and approaches to exploit large and complex datasets, to advance Precision (Personalised) Medicine in several disease areas. The training programme and experience of different international research environments cuts across traditional data and life sciences silos. The emphasis on translational research will support new collaborations between academics and the pharma and health analytics sectors. Our ESR projects will advance the state of the art on biomarker discovery, improve understanding of disease-specific molecular mechanism and target identification for optimal diagnostics, disease risk and treatment management, refine data generation and their management (including warehousing, disease specific and standardised approaches for data processing, visualisation and model development) leading to improved clinical study design, clinical sampling and more targeted therapeutics. This ETN will internationalise participants, and leverage EC and industry sponsorship, to structure and expand the unique training programme and advance emerging research areas, combining wet-lab, clinical and Big Data resources with computational and modelling know-how. To achieve a paradigm shift in research training this ETN brings together international leaders in Preclinical Science & Molecular Medicine, Systems Analytics, and Targeted Therapeutics, from academia and industry. These experts are ideally positioned to develop the proposed training programme and deliver a highly-trained workforce of next generation scientists, with the right mind-set, knowledge and skills, at the interface of Translational and Systems Medicine. The TranSYS training programme is designed to address a critical skills gap that is currently a bottle neck to advancing Precision Medicine.

Keywords: personalized medicine biomarker discovery,patient oriented management solutions,clinical trials,sample to insight,systems analytics,multi faceted knowledge retrieval,blockchain technology
The regulatory GENomE of SWine and CHicken: functional annotation during development (GENE-SWitCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Sweden,Belgium,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Agri-Aqua Labs (H2020-SFS-2018-2, 2018)
Start date: 2019-07-01
End date: 2023-12-31
Duration (months): 54.0
Total project cost (EUR): 6095780.0
EU funding (EUR): 5999886.0
Participants: 13
Project status: SIGNED

GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. The activation status of functional genome sequences varies across time and space, and in response to environmental perturbations. In full coordination and synergy with global effort and ongoing projects of the Functional Annotation of ANimal Genomes (FAANG) community, we will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG. A comprehensive plan of dissemination and outreach activities to a large audience of stakeholders will be implemented. The GENE-SWitCH consortium brings together partners representing pan-European excellence (including the academic institutions which pioneered FAANG) and world-leading animal breeding and biotech industry in a true co-creation effort. Overall, GENE-SWitCH will contribute to the global FAANG effort considerably, demonstrate how functional annotation of genomes can foster the advancement of genomic selection for immediate benefit to the breeding industry, and produce cutting-edge research paving the way to new studies and strategies for sustainable productions.

Keywords: genotype to phenotype,functional annotation,regulatory elements,monogastrics
Crafting Complex Hybrid Materials for Sustainable Energy Conversion (CREATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

With an unprecedented rise in solar cell efficiencies and ease of fabrication, hybrid lead halide perovskites (PbHP) have gained worldwide popularity. However, these materials still rely on the use of toxic Pb and lack of long-term stability. Moreover, distracted by a race for higher conversion efficiencies, the development of in-vacuum deposition techniques to reproducibly and controllably grow these hybrid films has been highly overlooked. This is now the main hurdle for the full exploration of Pb-free and stable hybrid halides, which might not be as defect tolerant or easily produced by solution process as PbHP. Therefore, a revolutionary method allowing the discovery of new sustainable complex hybrid materials is now, more than ever, of paramount importance. Here I describe a completely new approach that allows stoichiometric and layer-by-layer in-vacuum deposition of wide families of organic-inorganic materials, and their mixture in any pre-determined ratio. To overcome the specific challenges of hybrid film growth (incompatible volatility and solubility) I propose Pulsed Dual-Laser Deposition (PDLD) to decouple the deposition of the inorganic and organic sources with two distinct laser sources, a high energy (UV) and a low energy (IR), all in one vacuum system. Only this decoupling will allow the control and versatility to bridge the hybrid materials discovery gap and to tackle open scientific questions regarding the interplay between the organic and inorganic components, defect nature and their influence on optical properties, carrier scattering and recombination phenomena. Combining these fundamental insights with controlled growth, will enable the design of a new generation of stable and non-toxic hybrid films. My extensive experience in in-vacuum materials synthesis for solar cells, supported by the unique PLD expertise at the host institution will enable a leap in the discovery and understanding of hybrid materials for solar energy conversion and beyond.

Keywords: hybrid materials discovery rir maple pulsed laser deposition lead free hybrid halide perovskites hybrid organic inorganic materials combinatorial materials discovery
Wage inequality within and across firms: The role of market forces, government and firm policies (FirmIneq)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-05-31
Duration (months): 72.0
Total project cost (EUR): 1491803.0
EU funding (EUR): 1392166.0
Participants: 2
Project status: TERMINATED

Wage inequality in industrialised countries has increased sharply over the past decades, and much of this increase has occurred between rather than within firms. Furthermore, substantial inequality between men and women persists in all industrialised countries, and a large part of the gender gaps observed today is attributable to the arrival of children. In this proposal, we put firms at the centre of the analysis and ask the following questions: First, which market forces can (partly) explain the increasing wage inequality between firms? Second, how do government policies alter the wage structure? And third, how do firm policies and the firm environment impact on gender inequality? All projects draw on four decades of German social security records comprising the near universe of workers and establishments, which we augment with survey and administrative data on firms. In Project A, we investigate how two important market forces, increased product market competition and routine-biased technological change, contributed to the increasing wage inequality between firms, by changing which firms operate in the market (selection) and how employment is distributed across low and high productivity firms (reallocation), and by differentially affecting wage growth across firm types (differential wage growth). In Project B, we study how two prominent government policies, the introduction of a minimum wage and changes in business tax rates, affect wage dispersion between firms through selection, reallocation and differential growth effects. In Project C, we first analyse whether firm provided family-friendly policies, most notably flexible working times and child care facilities, can be effective at reducing gender inequality. We then investigate how the firm environment, specifically the presence of co-workers who are likely to have a working mother and hold more egalitarian gender attitudes, shapes mothers’ return-to-work decisions and earnings trajectories after childbirth.

Keywords: j16 economics of gender,j24 human capital,skills,labor productivity,j31 wage level and structure,wage differentials,e24 employment,unemployment,wages,o33 technological change
Carbon Nanomembranes for Energy Storage Applications (CNergy)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-05-01
End date: 2022-01-31
Duration (months): 9.0
Total project cost (EUR): 142857.14
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

CNM Technologies (CNMT) has developed a highly permeable and selective composite membrane with a nanometre-thin carbon nanomembrane (CNM) as active layer, which is – in the FET-open project ITS-THIN – introduced into demanding water separation applications. CNMT plans in a joint venture with the Dutch SME BLUE-Tec (also partner in ITS-THIN) to introduce these membranes into the water filtration market. Recently, scientists at Friedrich-Schiller University Jena (FSU) showed in the framework of the Graphene FET-flagship a high proton and lithium ion permeance of CNMs. Combining these findings with the ability to produce large-area CNM-composite membranes, a fully new technology is emerging: the use of ultrathin CNMs as separator membranes or proton exchange membranes (PEM) in battery and fuel cell applications. Thinner membranes promise a faster and more selective ion transport resulting in smaller, more powerful, and more reliable energy storage devices. This new window of opportunity will be explored in this feasibility study. In case of a positive outcome, CNergy will result in a business and action plan, how to introduce CNMs into batteries and fuel cells.

Keywords: membrane science and technology,carbon nanomembrane,batteries,separator membrane,fuel cells,proton exchange membrane,2d materials
Sonic migrations: Congolese rumba and utopias in 20th century West Central Africa (CONGOTOPIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: SIGNED

CONGOTOPIA proposes a new approach to the historical phenomenon of decolonization. Built on a rich bibliography in history, anthropology and sound studies, this project examines the movement of people, ideas and music put into motion by the Pan-African appeal of Congolese rumba. Inspired by early Afro-Cuban records, this dance music emerged in 1940s Leopoldville (current-day Kinshasa) and Brazzaville and soon became Africa’s most influential popular style thanks to the development—unique to Africa—of local radio stations and recording companies. Across different territories yearning for their independence, Congolese sound inaugurated a utopic Africa, audible over various Afro-Cuban rhythms and multi-voiced harmonies mixing Spanish with various African languages. While closely associated with pleasure, romance and fantasy, this popular music became a powerful marker of decolonization—in the 1960s, it “inflamed” Angolan nationalists’ spirit during the liberation war while allowing great Brussels-based musicians such as Manu Dibango to “jump in feet first with the question of Africa.” Examining the global, trans-imperial geography of Congolese rumba between Cuba, West Central Africa and Europe will reframe the conception of decolonization and the movements through which it unfolded in the period 1930-1974. By straddling the traditional divide between Francophone and Portuguese territories while reconnecting the African continent to the Southern Atlantic, it challenges established approaches to decolonization and sheds light on the history of a space (West central Africa) and from a perspective (colonized people’s) that have long been marginalized in the field of African studies. As the Congo(s) and Angola are impossible to fully dissociated from their multi-layered relations with Cuba in the period 1930-1974, the study of this musical region will deepen or understing of the Global South from an African perspective.

Keywords: sound studies,radio studies,history of african music production,pan africanism
SMART LOIRE VALLEY: Curiosity, Imagination and Intuition (SMART LOIRE VALLEY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,France,Morocco
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-FP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 3398400.0
EU funding (EUR): 1699200.0
Participants: 8
Project status: CLOSED

The region Centre-Val de Loire, located 130 km south of Paris, has a population of 2,5 million in an area of 40000 km². LE STUDIUM® Loire Valley Institute for Advanced Studies has its headquarters in Orleans, the capital. LE STUDIUM®’s mission is to build the human capital for research, development and innovation in region Centre, by attracting senior foreign researchers. The SMART LOIRE VALLEY (SLV) fellowship programme is designed to enhance this regional mission and support the regional implementation of the EU smart specialization concept. Over time it has demonstrated the benefits of outward looking research communities who adhere to the research values of LE STUDIUM®: Curiosity, Imagination and Intuition. For the past 10 years LE STUDIUM programmes have financed an average of 8 one-year fellowships per year and call for applications. This ambitious SLV programme – with the COFUND contribution – will fund a minimum of 12 researchers per call (4 calls for applications) over 5 years. This total of 48 worked years of research ensures region Centre will build its human capital in inter-sectorial and interdisciplinary research domains in order to drive regional and EU socio-economic outcomes from research investment and will foster the formation of new RTD poles of European scale in region Centre, enabling increased attractiveness and competitiveness. The SLV programme seeks to create synergies between disciplines and links with the industrial world in order to increase diversity and stimulate socio-economic development. Finally, it aims to develop outward looking interdisciplinary teams with a reputation in developing the EU economic landscape. LE STUDIUM® expertise resides in its capacity to manage and grow a global research network, able to create a new scientific value chain, leading to the emergence of innovative collaborative research and enterprise activity. This expertise will ensure the SLV programme achieves its goal.

Keywords: human capital,outward looking,diversity,innovation,public and private partnerships,science and society,flexibility,adaptability and reactivity
No Sword Bites So Fiercly as an Evil Tongue? Gossip Wrecks Reputation, but Enhances Cooperation (EVILTONGUE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Sweden,Hungary
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-12-01
End date: 2021-03-31
Duration (months): 64.0
Total project cost (EUR): 1973500.0
EU funding (EUR): 1195919.61
Participants: 2
Project status: CLOSED

Social norms in general, and norms of cooperation in particular, are the cement of all human societies. For the difficult problems of the maintenance and enforcement of social norms and of cooperation, humans have developed surprisingly complex solutions. Reputation mechanisms and gossip are certainly among the compound informal solutions. According to common wisdom, gossip channels mainly negative and often fictitious information. If it is so, how can dishonest gossip and the resulting biased reputations legitimize social order and promote cooperation? This is the main puzzle we tackle in the proposed project exploiting a wide scale of instruments. We use analytical modeling and agent-based simulation to derive hypotheses. We test simple hypotheses in small group experiments. We develop new methodological tools to appropriately analyze the triadic nature of gossip embedded in network flows of information. We utilize dynamic network datasets from primary and secondary school classes, and we gather qualitative and quantitative information from organizations to test conditional hypotheses about the role that gossip plays in reputation and cooperation in different developmental and social contexts of life. In addition, we apply new communication technologies currently under development to explore the hidden world of gossip and the dynamics of reputations in dormitories and organizations. With the insights gained, we can overcome common stereotypes about gossip and highlight how gossip is related to credible reputational signals, cooperation, and social order. Expected results will help us to outline the conditions that can promote cooperativeness in work groups, and they will help to construct successful prevention strategies of social exclusion and other potentially harmful consequences of the evil tongue.

Keywords: evolution of cooperation,reputation,gossip,social networks,signaling,honesty,agent based models,experiments,schools,organisations