Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOPEN (BIOPEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Germany,Germany,Italy,Finland,Poland,Greece,Belgium,Bulgaria,Netherlands
Call: Open-innovation Platform strengthening cooperation and joint development of bio-based industries and downstream sectors (H2020-BBI-JTI-2016, 2016)
Start date: 2017-05-01
End date: 2019-12-31
Duration (months): 32.0
Total project cost (EUR): 1205451.25
EU funding (EUR): 994531.0
Participants: 10
Project status: CLOSED

Nowadays, the center of the bio-based economy is the development of integrated value chains removing sector barriers, where market and product innovations are driven by societal needs and vision of brand owners, and require the collaborations between different sectors through new bio-based value chains (from feedstock to products), also establishing co-operations throughout industry clusters. Open innovation has been identified as the major driver to perform innovation through the flow (in and out) of knowledge, technologies and competences, for organisations to design, plan, and implement market and product innovations as well as to establish sustainable partnerships joining forces with customers, feedstock suppliers, academia, and financial sector. In BiOPEN a consortium highly specialized in the bio-based industry, composed by five European bio-based clusters, three open innovation expert companies, and one research centre, will embark on an ambitious programme to support collaboration and knowledge sharing in the bio-based industry, stimulating the set-up of co-innovation partnerships for the development of new products and markets in the sector. BIOPEN ambition is to become a single voice for the bio-based industries in Europe, gathering expertise and promoting engagement and involvement of industry, researchers and academia at European and national level, by setting up an Open-innovation platform addressing strategic cross-cutting challenges such as (i) clustering and networking to develop new value chains and favour the emergence of co-innovation partnerships across the value chains; (ii) Stakeholders engagement and support with regards to setting-up at least 20 co-innovation partnerships alongside existing and new value chains; (iii) creation of a knowledge centre collecting the prospective and insight of the community, and providing access to relevant information for markets and products innovations in the bio-based ecosystem.

Keywords: open innovation platform,knowledge centre,co innovation partnerships,cross sector collaborations
Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain (IM2PACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Italy,Germany,Sweden,Switzerland,Belgium,Hungary,France,Netherlands,United States,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Discovery and characterisation of blood-brain barrier targets and transport mechanisms for brain delivery of therapeutics to treat neurodegenerative & metabolic diseases (H2020-JTI-IMI2-2017-12-two-stage, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 17410136.0
EU funding (EUR): 9000000.0
Participants: 28
Project status: SIGNED

The overall aim is to further the understanding of the BBB in health and disease states towards the development of innovative brain delivery systems, especially for biopharmaceuticals (e.g., peptides, antibodies, etc.) and the identification of novel disease drug targets (Alzheimer’s Disease, MS, metabolic disease). The related key deliverables will be as follows: 1.Identification and validation of specific genes and/or mechanisms which are altered in brain endothelial cells in disease. 2. Generation, validation and characterisation of robust and predictive iPSC-derived BBB models: The developed models should be more reflective of the in vivo situation than existing models, in the healthy and disease states. 3. New, efficacious and safe mechanisms and technologies of brain delivery: The output of this topic should also result in an expanded and deepened understanding of the fundamental processes that underpin drug-trafficking across the BBB, which in turn can further support endeavours to elucidate novel and more efficacious brain delivery mechanisms. 4. Characterised new genetic models for the diseases of interest in this topic which are better amenable to evaluate disease-modifying agents. 5. Characterised mechanisms of neurotropic virus-mediated BBB and CNS penetration for development of selective brain delivery systems. 6. Established in silico/mathematical models in predicting BBB penetration of therapeutics (such as receptor-or carrier-mediated transcytosis for delivery across the BBB) and pharmacokinetics of biopharmaceutics in different compartments of CNS. 7. Identification of relevant translational readouts which are better amenable to elucidate the role of the BBB in the pathogenesis of neurodegeneration and could eventually lead to new targets for the treatment of the neurovascular causes of the diseases.

Keywords: blood brain barrier,induced pluripotent stem cells ipsc,brain delivery
Audiovisual Technologies for Next Generation Immersive Media (Immersify)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Austria,Germany,Sweden,Poland,France
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-10-01
End date: 2020-06-30
Duration (months): 33.0
Total project cost (EUR): 2488275.0
EU funding (EUR): 2062267.5
Participants: 6
Project status: CLOSED

VR and other forms of immersive media have the potential of disrupting the entire media industry with new user experiences that are more immersive and interactive compared to current video, cinema and TV. In order to reach a mature state beyond the current niche markets the quality of experience of VR media has to be improved in several ways. Immersify will develop key tools for allowing the next generation of immersive media applications. First, by developing advanced video compression technology tailored for the needs of the VR video it will be possible to deliver and display the huge files that will appear as a result of increased resolution, frame rate and better image formats. Second, it will allow the widespread of immersive content, and facilitate its distribution and exhibition by supporting multiple devices and environments such as PC- and mobile-based head mounted displays, multi-display systems, and dome, immersive cinemas and deep spaces. And third, it will allow content creators to produce highly personalized content with seamless interactivity by developing the required tools to combine high quality video, 2D/3D CGI, and interactive elements. Immersify will perform demonstrations in the world’s more important art and film festivals (Ars Electronica and Cannes Film Festival), will produce showcase content to demonstrate the creative and technical possibilities of the new formats, and will introduce innovative products (transcoders, media players, SDKs) in the market.

Keywords: immersive content,hevc,video codecs,uhd video,3d audio,live vr,interactive content
DIGItal MANufacturing Technologies for Zero-defect Industry 4.0 Production (DIGIMAN4.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Italy,Italy,Spain,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2024-03-31
Duration (months): 63.0
Total project cost (EUR): 3938028.68
EU funding (EUR): 3938028.68
Participants: 6
Project status: SIGNED

Industry 4.0 identifies a strategy aimed at enabling industry to a transition towards future ways of production. It refers to a set of recent innovations with potential to disrupt value chains, with a substantial impact particularly to the manufacturing sector. Industry 4.0 gravitates around one core rationale: recent progress in a variety of digital technologies has created unprecedented possibilities that result in huge improvements in operational effectiveness for manufacturing industries. The magnitude of this paradigm shift justified referring to Industry 4.0 as being the “Fourth Industrial Revolution”. There is a widespread consensus among the different stakeholders in the industry, at research institutions and in academia, that Industry 4.0 consists of essentially 9 clusters of key-enabling digital technologies that can radically innovate and disrupt the current manufacturing paradigms: Big Data and Analytics; Autonomous Robots; Simulation; Horizontal and Vertical System Integration; The Industrial Internet of Things; Cybersecurity; The Cloud; Additive Manufacturing; Augmented Reality. The DIGIMAN4.0 ITN will provide world excellent research training to 15 ESRs (Early Stage Researchers) in the field of digital manufacturing technologies for Industry 4.0 production proposing: (1) Innovative technological solutions for high quality, high throughput and high precision production (zero-defect precision mass-manufacturing of high performance products) for the manufacturing industry; (2) Cutting edge multi-disciplinary training in different domains (Precision Manufacturing Technologies, Digital Manufacturing Technologies, Integrated Production Metrology, Lean Manufacturing, Production Management); (3) Validation of different digital manufacturing technologies by integration into process chains for the production of advanced components in several sectors (medical and health-care, machine tool, hearing aid and micro acoustics, electronics, automotive, aerospace).

Keywords: industry 4 0,zero defect manufacturing,digital manufacturing technologies
Active Flow Control system FOR improving HYDRaulic turbine performances at off-design Operation (AFC4Hydro)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,Norway,Sweden,Norway
Call: Developing solutions to reduce the cost and increase performance of renewable technologies (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 4711589.25
EU funding (EUR): 4711589.25
Participants: 6
Project status: SIGNED

The AFC4Hydro project addresses the development of a novel Active Flow Control (AFC) system for improving off-design operation of hydraulic turbines by mitigating deleterious flow phenomena during steady and transient operation including ramping of produced load. The main effect being increased reliability and flexibility, and reduced wear and tear. More specifically, this innovative and affordable AFC solution, allowing efficient utilization of existing hydraulic turbines, is planned to be validated at small scale in a model turbine and at large scale in two prototype turbines. A combination of technologies will be used to reduce the pressure and load fluctuations exerted on the machine induced by the draft tube flow using: (1) injection of pulsating momentum (IPM) with a specific frequency, amplitude and phase by means of actuators; (2) injection of continuous momentum (ICM) in the form of water jets with controlled speed and orientation directed against the swirling flow. A structural health monitoring (SHM) system will be developed to evaluate the effects of the injection systems in the structural response of the rotor, generator and bearings. These measurements will be used to optimise the machine performance. For that, a Controller will be programmed and tuned to reduce pressure fluctuations, structural loads and induced vibrations in real-time operation by continuously adjusting the injection systems. The final AFC system will also be tested against demanding transients like ramp up and ramp down. Special attention will be given to mitigate the powerful and dangerous flow instability provoked by the vortex rope breakdown. The success of the proposal will permit to extend the operating range of already existing turbines beyond the stablished safety limits, to increase their efficiency at off-design operation, to be able to face more frequent transients and to reduce the maintenance and operating costs.

Keywords: hydropower,flow control system,efficiency,pressure pulsations,structure response,vibrations,life span,cavitation
Probing stresses at the nanoscale (Nanostress)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Summary: I will exploit novel molecules whose fluorescence properties depend strongly on the environment, notably on their spatial confinement, to study local stresses in complex materials down to the nanometer length scale and with unprecedented temporal resolution. Based on successful preliminary tests, I will develop this innovative methodology to tackle the fundamental scientific challenge of quantifying the long-range and very non-linear elasto-plastic stresses that govern the dynamics of friction, the glass transition and rheology. Friction is an immense global source of energy loss; the glass transition is perhaps the most important unsolved problem in condensed matter physics; and rheology in complex fluids is at the same time ubiquitous and poorly understood. The common denominator of these three open challenges is that in each, the material’s macroscopic mechanical behavior results from a complex interplay between microscopic stresses that remain ill characterized. This presents a scientific bottleneck as well as a major obstacle in the engineering of many important materials and tools such as ball bearings, plastics and foodstuffs. The fluorescent environmentally sensitive probes will allow me to achieve breakthrough results in three areas at once: (1) Locally measuring stresses in a frictional contact; (2) Probing the glass transition by local stress and viscosity measurements; (3) Visualizing and quantifying stress transmission in flowing complex fluids to explain non-Newtonian and non-local viscosity effects microscopically. I have a track record in providing new insights in long-standing problems, spurring renewed scientific interest, and in combining fundamental research with potential for technological innovation. By probing local stresses in much more detail than was possible before, this project will break open some of the toughest research areas in non-linear physics and (statistical) mechanics with far-reaching engineering consequences.

Keywords: friction,glass transition,yield stress materials
Multicomponent Protein Cage Co-Crystals (ProCrystal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1997502.0
EU funding (EUR): 1997502.0
Participants: 1
Project status: SIGNED

The possibility to direct nanoscale structural order in complex matter is an important prerequisite for the preparation and characterisation of next-generation functional materials. Hierarchically ordered multicomponent materials are particularly interesting in this respect, since they allow controlled integration of different nanoparticle/material building blocks into periodic nanostructures with lattice constants that are much shorter than the wavelength of light. However, most of the current nanostructured materials consist of fully synthetic or biological materials since the integration of biological and synthetic building blocks in a designed manner remains a challenging task. Here we propose an approach based on the co-assembly of biological protein cages and synthetic materials to bridge the gap between ordered synthetic materials and biological assemblies. Protein-based nanocages, such as ferritins and virus capsids, offer a complex yet monodisperse and geometrically well-defined cage that can be used to encapsulate different materials. We will utilize ferritin and virus particles as a size constrained reaction vessels to prepare monodisperse iron oxide nanoparticles and combine these electrostatically with synthetic noble metal nanoparticles to yield diverse crystal arrangement with coupled magnetic and plasmonic properties. During the course of the project, we will address important challenges, such as how to design responsive and collectively behaving biohybrid materials and to push the research and results beyond the current state-of-the-art. We aim to achieve this by using unconventional methods in designing, synthesising and applying new functional materials whose interactions and co-crystalline packing with biomacromolecules can be controlled. Potential outcomes include magnetically tuneable plasmonic assemblies, porous materials capable of simultaneous binding of organic and inorganic guest and protein cage crystal template inorganic nanostructures.
LAte Glacial RANGe Expansion (LAGRANGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

From around 25 to 20 thousand years ago, most of northern Europe was covered by ice and humans retreated into refuges in the warmer southern territories. The archaeological record of the Western European Late Pleistocene clearly indicates a refuge encompassing the areas of Cantabria, in northern Spain, and Aquitaine, in southern France. Both archaeological and genetics evidence agrees that it was from this “Franco-Cantabrian” refuge that Western Europe was repopulated in several phases starting at around nineteen thousand years ago. As pioneer groups expanded their ranges into previously uninhabited northern territories, Late Glacial hunter-gatherers had a unique opportunity to engineer their evolving ecosystem or niche. According to the Niche Construction paradigm such practices deeply change the selective pressures of that niche on its populations, both human and non-human, thus affecting not only cultural transmission, but also biological/genetical transmission: a triple inheritance model. The LaGRangE project proposes to study the Late Glacial hunter-gatherer range expansions, and the role of Niche Construction in these. This will be achieved by an interdisciplinary approach to the problem applying established Computer Science methods to archaeological data. Firstly Niche Construction triple-inheritance models will be modelled to understand how niche construction affects the dispersal dynamics of a given population. This new understanding will then be used to model the Late Glacial dispersal of humans out of the Franco-Cantabrian refuge, on a biogeographically realistic domain. This approach will help identify routes, preferred habitats and other dispersal choices taken by the expanding groups.

Keywords: prehistoric human dispersals,upper palaeolithic,niche construction,mathematical modelling
Modular green-energy recovery and business model (ENERCOVERY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain,Portugal
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Gasification is a thermal process that converts organic matter into fuel gas (Syngas) at high temperatures (above 600 ºC). When Syngas is burnt in a combustion engine, simultaneous production of electricity and heat is obtained in one only step. The main limitation of current gasification plants are the great amount of wastes needed to work properly, which makes this technology very difficult to be implemented in industrial sectors with less quantity of wastes production. This market demands a more flexible, modular and portable technology. On the other hand, the pellet production is a process with very high energy consumption, mainly due to the need of raw material drying, and with a waste product suitable for energy recovery by gasification. The general objective of this innovation project is to place in market a breakthrough energy technology for pellet manufacturing industries with high energy consumption that will allow valorising their wastes, currently with none or less economic value, by means of a modular and portable gasification-CHP plant installed in their facilities. Additionally, the project development will help to solve a serious environmental problem caused by the excessive accumulation of wastes in landfills. In order to reach this objective, the consortium will validate the study of this energy technology carried out in pellets manufacturing industries by scaling-down the gasification plant currently used for tens of tonnes per day of waste and optimise the functional parameters to the type of waste treated to ensure the same process yield as bigger plants. Phase 1 of ENERCOVERY aims to ensure the viability of the project. A technical analysis on the viability of the implementation of a gasification-CHP plant in pellet manufacturing process and a business plan will be developed.

Keywords: renewable energy,industrial wastes,wood pellets,gasification,electricity