Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Critical metal recovery from industrial wastewater by bioflotation using surface active siderophores (BioFlot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

The recycling rates of critical metals like In, and Ga are very less and it is high time to improve their recovery from secondary sources in an environmentally friendly way. However, the low concentration of target metals and presence of other metals in the industrial wastewater makes the recovery challenging. BioFlot aims to explore the use of amphiphilic siderophores (marinobactins) from Marinobacter sp. as highly specific extractants for recovery of CRMs (In, and Ga) from secondary sources (industrial wastewater) by means of bio-flotation technique. Marinobactins are composed of amphiphilic and hydroxamate functional groups which makes them an ideal candidate for bioflotation. The marinobactin-CRM interactions will be studied at molecular levels which will shed the light on their unexplored capacities and form the basis for the development of recovery process. The project proposes to employ the marinobactins as green flotation extractants in bioflotation technique for metal recovery and subsequent extraction and optimization of process parameters for maximum selective binding of metals and marinobactins so as to increase the flotation yield. And further optimization for separation of marinobactin from metals in flotation product to regenerate marinobactin and recover target metal. The next phase of the project would involve semi-continuous and continuous experiments to scale-up the best possible configuration selected during the batch study. Finally, an economic evaluation will be carried out to support the commercialization of the developed technology. This project will develop a novel and ecofriendly recycling process which will increase the recycling rates, reduce the waste and proliferate the circular economy in EU and also contribute in reducing its CRM dependency on non-EU countries. It will also train the experienced researcher in developing green technology and soft skills and make the host eminent in innovative biotechnology.

Keywords: critical metals,recovery,wastewater,siderophores,bioflotation
Photonic Integrated Comb Source (PICOMB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2357951.25
EU funding (EUR): 1650565.88
Participants: 1
Project status: CLOSED

Data will grow tenfold by 2025 to 163 ZetaBytes. The rise in mobile video, video-on-demand, cloud and other bandwidth intensive services are putting strain on the optical communication networks that make up the internet. Laser technology is at the core of moving all of this data between users and datacentres. Data storage and processing innovations have outpaced transmission innovations leading to a data transmission bottleneck. Next generation laser technologies are needed to remove this bottleneck. Pilot Photonics has developed a disruptive laser technology that can displace the “single mode” lasers that have been used in this market for more than two decades. Our opportunity is to licence and sell our differentiated solutions into the $13BN laser market. Known as Optical Combs, these new lasers offers the disruptive value proposition of reduced cost, footprint and power consumption, with a simultaneous increase in performance, and capacity. Pilot Photonics’ competitive advantage is its ability to generate optical combs using photonic integration. This state-of-the-art technique combines multiple optical functions on a single photonic chip, and is analogous to the development of microchips in the 1960s which combined multiple electronic functions on a single silicon chip. The use of photonic integration drives huge efficiencies in cost, footprint, power consumption and performance and Pilot Photonics has patent protection on the world’s smallest and most versatile optical comb source, making it suitable for use in long haul optical networks for the first time. This Phase 2 project will see the technology reach market acceptance. The project will enable Pilot Photonics to generate revenue of more than €50m from this product alone, within 5 years of the project start representing a >10% share of the $500m market segment. The company will create 26 new jobs, grow its portfolio of IP, and increase the competitiveness of the European Photonics industry.

Keywords: photonic integration,optical comb sources,elastic optical networking,superchannels,terabit,optical transport
Blood test for clinical therapy guidance of non-small cell lung cancer patients (LungCARD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Spain,Uzbekistan,Azerbaijan,Poland,Türkiye,Russian Federation,Serbia,United States,United Kingdom,Morocco,Nigeria,Peru,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-10-31
Duration (months): 70.0
Total project cost (EUR): 1039500.0
EU funding (EUR): 976500.0
Participants: 17
Project status: CLOSED

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not present mutations in such gene, should be treated with chemotherapy. Currently, the laboratories use PCR and Sanger sequencing technologies to perform the EGFR analysis from tumour biopsies - Fixed Paraffin Embedded (FFPE) samples. Still, some patients (e.g., 30% in UK) may never get histological confirmation because they are too sick to make a biopsy. Furthermore, the results obtained with current methods still present low quality, mainly due to poor quality/low yield of DNA extracted from FFPE samples. The FP7 LungCARD project (www.lungcard.eu) has developed and demonstrated a LungCARD system - an automatic system composed by microfluidic chip and chip analyser - that allows to capture circulating tumour cells (CTCs) from blood samples, amplify by multiplex PCR and detect EGFR mutations, including also a software for data analysis and report. Although this new blood test has proven to be faster, cost-effective and human error-free, the detection of somatic mutations in EGFR gene at frequencies lower than 20% is still a weak point. Therefore, the main project’s goal is to benefit from this technology, through the development, improvement, integration and validation of the LungCARD system with NGS workflow and development of a software for automatic reporting clinical results. However, LungCARD project aims to go further, by putting together a global and unique network of multidisciplinary scientists for exchange of knowledge and research training focused on non-small cell lung cancer.

Keywords: lung cancer
New dimensions and approaches to anti-corruption policy (ANTICORPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-09-09
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Corruption continues to be a central issue in the governance of institutions (public, private or mixed). The scholars and practitioners working on the topic are facing with two challenges: (1) measurement of corruption, which is a thorny issue on empirical studies of corruption, and (2) the increasing awareness of the failure of most anti-corruption policies. The overarching objective of ANTICORPOL is to introduce a new dimension in the discussion of corruption: the degree of corruption (i.e., the depth as opposed to the spread). The benchmark of ANTICORPOL is this: it is unclear whether a system (organization, public administration) with few individuals who terribly deviate from their duty is less/more corrupt, than one with many corrupt individuals who only slightly deviate from their duty. Therefore, the degree of corruption of its members must be an integral part of the debate about corruption in a system and the development of effective policies against it. This proposal raises the following research questions: (R1) How can the degree of corruption of an individual be defined? (R2) Which policies are effective in reducing the distortion of duties of corrupt individuals? (R3) How can the degree of corruption be incorporated into measurements of corruption, at organization/country level? The proposed research is based on both theoretical and empirical methods and the combination of qualitative, comparative and quantitative analysis. This project is inherently of interdisciplinary interest because corruption is a multifaceted issue with economic, political and sociological dimensions. The research findings will contribute to a deeper understanding of corruption and further to the evaluation of the quality of democracy.

Keywords: corruption decisions,bribes,degree of corruption,anti corruption policies,public administration,development
Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering (PRIUS-TE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-09-06
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

On an aging society, our quality of life depends significantly in our capability to regenerate or engineer replacements for diseased and damaged tissues. One of these is the osteochondral interface. Over 30% of the population above the age of 65 is affected by osteochondral defects, being the most common cause of disability in older adults. PRIUS-TE (Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering) aims to regenerate the osteochondral interface with the use of hierarchical piezoelectric materials capable of stimulating mechanically, electrically and chemically the cells. Cartilage is unable to adequately self-regenerate due to its avascular character, the high content of extra cellular matrix (ECM) and the quiescent character of cells within (chondrocytes). Damage or diseases such as osteoarthritis (OA) lead to degeneration, reaching subchondral bone and generating an osteochondral defect. Clinical treatments rely on microfracture techniques that recruit tissue-specific progenitor (or stem) cells from the bone marrow, and form a de-novo cartilaginous tissue. However, the recruited cells are not able to self-organize and differentiate into phenotypically coherent cells. This results in the formation of unstructured and isotropic tissues with impaired mechanical properties that fail at long term. Current TE strategies are mainly based on isotropic materials that disregard the intrinsic multi-zonal character of the native tissue. PRIUS-TE takes inspiration from the structure and intrinsic properties of the osteochondral interface. It is based on hierarchical scaffolds that mimic the structure, cell microenvironment and fixed ionic charge responsible of the mechanical properties of the native tissue. These gradient, hierarchical and piezoelectric scaffolds will stimulate the recruited cells electrically, mechanically and chemically promoting the layer-specific cell growth, differentiation and the formation of a coherent tissue.

Keywords: articular cartilage,osteochondral defect,additive manufacturing,self assembly,ultrasound stimulation,piezoelectric materials
ZAPINAMO – Affordable, future-proof rapid charging infrastructure for electric vehicles from stored [clean and economical] energy (ZAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The European Environment Agency’s ‘Air Quality in Europe 2016 Report’ attributes air pollution to over 467,000 premature deaths across Europe every year. The total economic cost of premature deaths in the WHO European Region has been estimated at €1.47 trillion each year. Emissions from petrol and particularly diesel vehicles (esp. ‘PM2.5’) are a major contributor to this crisis. Electric vehicles (EVs) are well suited for modern Smart City environments; they produce zero emissions at point of use and less noise pollution compared with gasoline-powered vehicles. However, the growth of charging infrastructure has not kept momentum with vehicle development, limiting the widespread uptake of EVs. The currently available unreliable, slowcharging infrastructure is ineffective, making longer journeys uncertain, causing ‘range anxiety’. Slow chargers take 9 hours or more to charge a car, but upgrading slow chargers to rapid charging posts (involving inflexible sub-station upgrades and associated disruption over a long period) is impractical and costly for local authorities. Existing EV owners consistently report a desire for more extensive – and rapid – public charging infrastructure. ZAPINAMO is an easily deployable, stored energy based EV rapid charging system; just like a power bank for a mobile phone, but bigger and faster. ZAPINAMO can harvest from various sources, preferably renewables and potentially off-grid supplies. ZAPINAMO utilises highly sophisticated and extremely reliable battery technology together with innovative ZAPINAMO power electronics to provide energy at a point where and when the EV user wants it—even totally off-grid—at the fastest rate / highest power the EV can handle. By advancing sustainability, affordability and security of supply along with economic growth, ZAPINAMO addresses key challenges in the EC Transport White Paper.

Keywords: rapid charging,sustainable transport solution,urban air pollution,renewable energy
VEZ (VEZ)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-08-31
Duration (months): 10.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

VEZ will be a zero emission boat for public transports in water cities, featuring mission and characteristics at least similar to the typical Venice ‘Vaporetto’, which can be considered a worldwide reference for public water transports. VEZ will be powered by a hybrid energy generation and management system based on hydrogen-air fuel cells, roof mounted PV cells and electric batteries, demonstrating the possibility of reaching “Zero emission” in boat services even in such stressing conditions as in the Venice canals. It will exploit the advances that the automotive industry drove on those technological areas, particularly in Europe. A few similarly powered boats exist for passengers' transports but for broader harbour waters or rivers. VEZ will be innovative as it will be conceived and designed for narrow and highly congested waters, by a whole systems engineering approach, optimizing the power system to be managed efficiently under the frequent start and stop requirements deriving from regular line service in relatively narrow and congested canals, such as the Venice Grand Canal, with potential application also in other worldwide "water cities". The low wave making hull will be optimized vs. power system and payload layout, manoeuvrability and safety requirements. The vessel will be an improvement also from the comfort point of view by the lower noise obtained and the integrated heat pump air conditioning. Another innovation, from a large fleet perspective, will be the lightweight Aluminium made hull, for better material recyclability and accommodation of the heavier energy generation and storage system. Phase 1 will cover: State of the art and market analysis of zero emission passenger boats; Legal constraints, related to onboard fuel storage & handling; Concept design; VEZ functional and technical specification; VEZ lifecycle cost estimate; Phase 2 cost estimate (engineering and management, prototype construction, model test tank).

Keywords: hybrid propulsion,zero emission,urban transport,water transport,hybrid boat,fuel cells,electric propulsion
Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation (NESTOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Spain,Argentina,Spain,Slovenia
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-10-01
End date: 2026-03-31
Duration (months): 54.0
Total project cost (EUR): 837200.0
EU funding (EUR): 837200.0
Participants: 6
Project status: SIGNED

Recent advances in nanotechnology have already provided excellent platforms to reshape many areas of biocatalysis and healthcare, and yet many challenges are still being faced to produce artificial nanozymes with better catalytic efficiency. Pending achievements include having enhanced enzymatic robustness and stability while keeping the key aspects of natural enzymes such as high specificity, low toxicity and bioavailability. Consequently, there is currently a real demand for better-designed nanozymes capable to solve these challenges for the different industrial and health requirements. NESTOR project aims to develop atomically-designed nanozymes based on versatile iron-oxide-based materials, to assess their true toxicological impact and to theoretically model the microscopic mechanisms of their enzymatic-like reactions (e.g., catalase-like, peroxidase-like, etc.) and to achieve a product-oriented enzymatic activity with minimum toxicological impact, a highly relevant societal concern. The outcomes from NESTOR project are expected to provide a better control of enzymatic reactions inside living entities together with the additional properties from the new materials such as magnetic actuability, imaging or heating. These research goals are embedded in the motivation of establishing a dynamic network with NESTOR, aimed to train the next generation of materials scientists, theoretical physicists, chemists, toxicologists and medical doctors in a highly interdisciplinary research environment so they can benchmark upcoming challenges concerning the new biomedical and environmental challenges to come. This next generation of open-minded scientists with true knowledge of multidisciplinary work will be an essential actor in the complex interactions between nanotechnologies and society that lay ahead.

Keywords: nanozymes,nanocatalysis,free radicals,dna damage,atomistic model,magnetic nanoparticles,reactive oxygen species,density functional theory
DNA-protein crosslinks: endogenous origins and cellular responses. (DNAProteinCrosslinks)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1497375.0
EU funding (EUR): 1497375.0
Participants: 1
Project status: SIGNED

This project aims to address the most pressing questions in the emerging field of research on DNA-protein crosslinks (DPCs) and their repair. Covalent DPCs are highly toxic DNA lesions that block virtually all chromatin processes. DPCs are induced by various exogenous and endogenous agents, but dedicated repair mechanisms were unknown. It was previously assumed that DPCs are repaired by canonical DNA repair pathways. This has changed with my recent discovery of a specific and conserved DPC repair mechanism. I established that proteases of the SPRTN family degrade the protein components of DPCs, which maintains genome stability and ensures tumour suppression. Strikingly, DPC repair by SPRTN is essential for cellular viability, which suggests that cells are constantly challenged with substantial amounts of endogenous DPCs. I hypothesize there is an entire unexplored pathway regulating protease-based DPC repair and that DPCs are key drivers of endogenous genome instability. I will employ genetic screening approaches and develop novel functional assays to systematically define the components and working principles of this novel DNA repair pathway in mammalian cells. I will determine how DPCs are detected in a chromatin context, how different repair activities are coordinated and connected to cellular processes such as replication or transcription. Moreover, I will identify the currently elusive origins of endogenous DPCs, by investigating the essential role of the SPRTN protease. My results will not only provide insights into an essential cellular quality-control mechanism but also unravel processes causing genomic instability in human cells. Importantly, many chemotherapeutics used in the clinic exert their cytotoxicity by inducing DPCs. My results will thus have imminent implications for human health and have the potential to reveal novel drug target candidates for combination anti-cancer therapy.

Keywords: genome maintenance,endogenous sources of dna damage,dna protein crosslink repair,sprtn protease