Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the molecular regulation of microbe-induced plant resistance to root-knot nematodes in tomato (MIR2RKN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-16
End date: 2028-01-15
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Root knot nematodes (RKNs) represent a major problem for global food security. Current control strategies of RKN have critical limitations. Beneficial root-associated microbes, like rhizobacteria, can enhance the plant immune systems, boosting resistance to a broad spectrum of attackers, including RKNs. This phenomenon, known as Microbe-Induced plant Resistance (MIR), has emerged as a promising biotechnological tool for a sustainable RKN control. However, there are still important challenges in the implementation of MIR-based products in RKN protection programs. We are just starting to uncover molecular mechanisms underlying MIR’s effectiveness to RKN, which have complex, long-term relationship with plants, including well-differentiated infection stages. The main aim of MIR2RNK is to contribute to elucidating molecular mechanisms that regulate MIR functioning to RKN in tomato. MIR2RKN will use a multidisciplinary approach combining multi-omics high-throughput techniques, computational biology, functional genomics, and mesocosm experiments to achieve three main objectives: (1) To evaluate the impact of rhizobacteria on tomato resistance to RKN throughout the infection cycle, and validate the economic viability of these findings under close-to-real field conditions; (2) To uncover key molecular traits of the tomato plant immune system that regulate rhizobacteria-MIR to RKNs across the infection cycle, and (3) To decipher the specific role of tomato polyamine metabolism in rhizobacteria-MIR to RKNs throughout the RKN’s infection cycle. MIR2RKN will enhance our understanding of how MIR is regulated during the dynamic infection cycle of RKNs. This knowledge on how MIR functions, will contribute to developing sustainable crop protection strategies against RKNs. Moreover, MIR2RKN will strongly benefit the applicant, as he will gain independence in research, wider visibility, and will be trained on fundamental skills for proceeding in the next step of his scientific path.

Keywords: beneficial soil microbes,induced systemic resistance,root knot nematodes,plant defense mechanisms,transcriptomics,system biology,molecular signaling,phytohormones,secondary metabolites
Advanced Research and eXploration for Interoperable Value in European Heritage (ARXIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Germany,Greece,Portugal,Spain
Call: A European Collaborative Cloud for Cultural Heritage – Innovative tools for documenting, interlinking and organising data (HORIZON-CL2-2024-HERITAGE-ECCCH-01, 2024)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 4246856.8
EU funding (EUR): 3989329.51
Participants: 9
Project status: SIGNED

ARXIVE revolutionizes the documentation, analysis, and dissemination of cultural heritage objects by developing cutting-edge tools and methodologies integrated into the European Collaborative Cloud for Cultural Heritage. Addressing fragmented on-site workflows and the challenges of preserving both tangible and intangible cultural assets, ARXIVE introduces a semantic archival system that provides advanced solutions for annotating evolving digital twins. These tools empower cultural heritage professionals to create semantically rich, context-aware documentation while streamlining processes for research, preservation, and dissemination. The project enhances the accessibility, organization, and contextualization of cultural heritage objects by integrating high-fidelity 3D reconstructions, granular annotations, AI-powered annotated bibliography tools, and narrative-building applications. It ensures interoperability with established standards principles, fostering seamless collaboration and long-term sustainability. Through two Use-Case Pilots (Greece and Portugal) the tools will be tested and validated in real-world environment, a through a comprehensive Financial Support to Third Parties program to funding and accelerating at least twenty projects via two diverse Open Calls, ARXIVE will engage different stakeholders, promote knowledge sharing and capacity building, and foster the scalability and wider adoption of ECCCH tools. Leveraging the expertise of a multidisciplinary consortium of nine partners from five countries, ARXIVE establishes strong synergies with ECCCH initiatives to amplify the impact of European cultural heritage. By advancing cutting-edge methodologies and fostering collaboration, ARXIVE positions European heritage at the forefront of innovation, ensuring its preservation and relevance for future generations.

Keywords: ai,cultural heritage,eccch,fstp,kgs,eosc,eccch,echoes,fair,social sciences,humanities
Safe, sustainable, lIghtwEight and high-perfoRmance Ni-Rich NMC battery pack with Advanced cell-to-pack monitoring for decarbonising heavy-duty vehicles (SIERRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: France,Switzerland,United Kingdom,Austria,Germany,Italy,Spain
Call: Size & weight reduction of cell and packaging of batteries system, integrating lightweight and functional materials, innovative thermal management and safe and sustainable by design approach (Batt4EU Partnership) (HORIZON-CL5-2024-D2-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 9962275.75
EU funding (EUR): 7998914.88
Participants: 14
Project status: SIGNED

In the HDV market, the main considerations for battery packs are safety, durability and mass energy density. High-energy NMC cells are very appealing for achieving the target for future battery packs. However, further developments are needed for high-energy NMC battery packs to meet the stringent safety and durability standards of the HDV market. Additional factor to achieve high mass energy density is reducing the weight of the battery pack, but lightweight structures are less common in HDV due to safety and durability constraints. To respond to these challenges, SIERRA project will develop a safe, sustainable, lightweight and high-performance Ni-rich NMC battery pack with advanced cell-to-pack monitoring for decarbonising HDV. SIERRA project will propose several innovations: 1 - Multiscale modelling of the battery pack to propose compact pack design and to simulate its thermal and mechanical behaviour; 2 - One-shot manufacturing of lightweight multimaterials casings with low environment impact; 3 - Mutli-scale advanced monitoring (SHM, thermal mapping, SoC, SoH) and reduction of the complexity of BMS architecture; 4 - Full integrated cooling system and printed busbars to respond to fast charging requirements and increase performance over the complete operational conditions. The specific use case targeted by the project is the bus market, and SIERRA battery pack will be validated at TRL6 for this market. The integration into the vehicle will be simulated using a digital twin. All SIERRA activities will follow the methodology defined by the SSbD framework. SIERRA consortium is composed of 11 partners (+60% industrials), all with exceptional R&D platforms and proven track records. SIERRA battery pack sales are projected to generate a total cash flow of €87 million between 2030 and 2034, accompanied by the creation of 525 jobs, thereby contributing to the expansion of the EU clean mobility market. SIERRA project will also generate 13 KERs and 8 patents.

Keywords: battery pack,nmc,bms,piezoelectric sensor,eis,smart battery,composite casing,recycled carbon fibre,printed busbar,soh,soc,fast charging,thermal modelling,electric bus,heavy duty vehicle
VALORISATION AND OPTIMIZATION OF NOVEL FIRST-IN CLASS SUCCINATE-DEPLETING THERAPIES (SUCZYME)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-01-31
Duration (months): 7.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

SUCCIPRO is a spin-off company from Pere Virgili Health Institute and Rovira Virgili University. It is an early-stage drug development company focused on therapies able to modulate the succinate-SUCNR1 pathway, which have strong potential on many inflammatory and metabolic disorders. Currently, the company is developing SUCZYME, a novel first-in-class oral enzyme therapy able to deplete succinate that has Crohn's Disease as a first indication. SUCCIPRO will lead the development until the end of Clinical Phase 2a, when the asset will be licensed to a bigger pharma company. Current proposal aims to conduct critical technical and business activities with the overall goal of raising a first seed investment round. From a technological perspective, during the project the team will advance in the development of the enzyme therapy by partnering with an innovative company expert in enzyme engineering able to improve our candidates in terms of specificity, activity and stability. Later, we will conduct in vitro and in vivo efficacy studies that will enable the designation of final lead candidate. In parallel to the technical development, and in order to have more a more accurate vision about the European market, we aim to perform early price & reimbursement and market studies in Europe. We will also participate in the activities organised by InvestEU and the Enterprise Europe Network and we will introduce our company into the US start-up ecosystem to expand company's innovation network and look for investment in the US. Overall, the project will contribute to increase the TRL level of our asset, improve our competitiveness and visibility within the international biotech sector and support us in the raising of a seed investment round.

Keywords: succinate,enzyme therapy,metabolism,crohn s disease
New-generation wrist exoskeleton with variable stiffness and optimized biomechanics for tremor suppression (NextTremor)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-02
End date: 2027-09-01
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 10 million individuals globally. Tremors, which are the most prevalent symptom, afflict approximately 80% of PD patients. These tremors can significantly hinder daily activities such as eating, dressing, and washing, among others, and can also impose a substantial psychological burden on the affected individuals. Consequently, suppressing tremors in PD patients is crucial for enhancing their quality of life and alleviating psychological stress. In response to this need, Dr Guohui Wang, an experienced researcher from Shanghai University in China, moving to the University of Exeter in the United Kingdom to collaborate on the project titled "New-generation wrist exoskeleton with variable stiffness and optimized biomechanics for tremor suppression (NextTremor)" under supervision of Dr Xijin Hua and Prof. Marios Politis. The objective of this project is to design and develop an innovative, lightweight, and cost-effective 3D-printed wrist exoskeleton with adjustable stiffness, which facilitates personalization and optimizes biomechanics for the effective suppression of tremors of varying intensities. The project will leverage the fellow's expertise in mechatronics, sensors, wearable devices, and 3D printing, in conjunction with the primary supervisor's proficiency in musculoskeletal modelling and human movement analysis, and will be further supported by the secondary supervisor's specialized knowledge in PD. Thus, this initiative seeks to establish a knowledge-sharing platform that enables the fellow to acquire new skills while fostering the exchange of expertise between the fellow and the host in the domains of biomechanics, musculoskeletal modelling, human movement analysis, mechatronics, sensors, wearable devices, 3D printing, and Parkinson's disease.

Keywords: wrist exoskeleton,tremor,biomechanics,parkinson s disease,human movement analysis
The ecophysiology of sleep under global change (SLEEPCHANGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Sleep is ubiquitous in the animal kingdom and serves essential biological functions, yet, sleep incurs substantial costs in terms of increased vulnerability to predators and reduced time for acquiring resources. How sleep is regulated by ecological factors (e.g., predation) and expressed in the natural world is highly understudied, more so in non-model taxa of reptiles and amphibians. Further, sleep can be comparatively and mechanistically understood through the lens of environmental change processes such as biological invasion and urbanization. In this study, we propose to examine the degree of lability in sleep trait expression of reptiles and amphibians under environmental change and how adaptive these responses are. We will employ a comprehensive suite of electrophysiological and behavioural measures of sleep and quantify responses to, i) increased exploration during rapid population expansion of early stage biological invasion, ii) reduced predation-risk during biological invasion, iii) novel stressor of night light due to urbanization. The project will break new grounds in terms of quantification of sleep in non-model taxa using state-of-the-art technology alongside behavioural measures, application of an eco-evolutionary framework to sleep research, and understanding the role of global change processes in shaping sleep in the animal kingdom, thereby generating insights into the regulation and expression of sleep in the natural world. Through the project, the researcher will learn neurophysiological techniques of sleep quantification from the host and use novel technology developed by the collaborator. The host's distinguished academic record, domain expertise in sleep electrophysiology of reptiles and amphibians, and large research network make him uniquely qualified to transfer expertise to the researcher and help him build an interdisciplinary skillset and become an innovative academic in the field of sleep ecophysiology research.

Keywords: electrophysiology,electroencephalogram,biological invasion,urbanization,anti predator,sleep ecology
The first bioengineered air purifier (Neo Px)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Neoplants, created in 2018 in France, is the first company in the world to develop a bioengineered air purifier, Neo PX, a revolutionary nature-based solution designed to combat indoor air pollution with unmatched efficiency. Neo PX, composed of a houseplant and a custom designed shell, integrates a microbiome specifically bioengineered to increase the natural capacity of the plant to remediate Volatile Organic Compounds (VOCs), harmful indoor air pollutants present in households. Neo PX, currently at pilot stage, exhibits up to 30 times increased capacity of VOCs remediation vs a regular houseplant and reduces indoor air pollution by up to 85%, which is unprecedented in the field. This breakthrough, stemming from 5 years of R&D in bioengineering and genetics, is allowing the company to pioneer a whole new category of products. Recognized and supported by the innovation ecosystem and seasoned European and international investors, Neoplants’ 26 person-team regroups decades of postdoc experience in synthetic biology and top scientists, backed with a world-class Scientific Advisory Board of international experts. Neoplants also built a cutting edge synbio and air quality lab close to Paris, one of the largest and most sophisticated facilities of this kind in Europe. With no significant marketing investment to date, Neo PX has demonstrated an impressive organic market traction and enthusiasm from individuals, with almost 50,000 waitlisters in Europe and the US, and the recent successful launch of a pilot version of Neo PX in the US. We are now poised to scale up and capitalize on this exceptional momentum to introduce Neo PX in both the EU and the US, but needs EIC support to move from the current pilot product towards its final product vision and full potential. Neo PX is only a first step towards longer term strategic use cases, from indoor pollution to climate change, in line with Neoplants’ mission to put nature at the heart of innovation to drive positive impact.

Keywords: bioremediation synthetic biology directed evolution microbiome plant systems houseplant soil bacteria indoor air pollutants depollution volatile organic compounds formaldehyde btx deep tech
Theory of Tone (THoT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2418010.95
EU funding (EUR): 2418010.95
Participants: 1
Project status: SIGNED

Tonal languages are no longer perceived as exotic. According to modern concepts, about 50-60% of the world's languages are tonal. However, the main shortcoming of the majority of research dedicated to tones consists in a narrow panorama of research. It is most often limited either to the description of the tonal system of a certain language or to a particular problem, like correlation of tone and accent, etc. The goal of the project is twofold: (a) to prove that any tonal system can be classified into one of the (presumably) four categories and b) typical trends of change of these systems in diachronic perspective are movements from one category to another according to rules that have to be identified. It will be done on the basis of rich language data. The project covers all major areas of localization of tonal languages. Within a five-year project, it is impossible to explore all the tonal languages of the world. Thus, a balanced sample of 150-200 languages will be carefully studied. This sample takes into account the language family, area of distribution and other relevant parameters including information on language structure, characteristics of the tonal system, functions of tone, tonal density index. This ambitious goal can be achieved through the participation of leading specialists in tonal languages, like Larry Hyman and other prominent tonologists. The present project is a break-through as it will make possible to discover substantiate in-depth correlations between suprasegmental characteristics of a language, correlations between suprasegmental system and other parameters, such as genetic affiliation, areal distribution or morphological structure. The adopting the terminological system that can be applied to any tonal system of any language, will lead the research team to an adequate comparison of tonal systems. Special attention will be paid to intermediate types. The study of languages will combine typological, genetic and areal approaches.

Keywords: linguistic tone,tonal density index,tonal systems,suprasegmental systems,toneme
PHOTO-INDUCED ELECTRON DYNAMICS AT THE TRANSITION-METAL OXIDE–WATER INTERFACE FROM TIME-RESOLVED LIQUID-JET PHOTOEMISSION (WATER-X)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1998125.0
EU funding (EUR): 1998125.0
Participants: 1
Project status: SIGNED

Photocatalytic water splitting using transition metal oxides (TMOs) has the potential to play a key role in the sustainable large-scale production of hydrogen. Due to their activity, cost-effectiveness, and stability TMOs are viewed as attractive materials to catalyze water splitting by harnessing solar energy. A major challenge is effectively preventing the recombination of electrons and holes in the TMOs produced upon (solar) light absorption. While these charge recombination processes occur on the pico-to-nanosecond timescale, the whole water splitting process is almost 12 orders of magnitude slower! This huge difference urgently demands a better understanding of the underlying mechanisms and charge-driven chemical reactions involving electron transfer (reduction reaction) or hole transfer (oxidation reaction) that take place at the TMO semiconductor–liquid interface. In my WATER-X project I will investigate these sub-10-picoseconds processes at the interface of TMO nanoparticles in bulk water by using time-resolved femtosecond laser photoelectron spectroscopy by applying liquid microjet setup. The objective is to measure the early-time molecular intermediates and their associated electronic-structures, their lifetimes, energetics, photoelectron angular distributions, and decay mechanisms of the short-lived molecular intermediates. With this knowledge we can determine the exact mechanisms of light-induced water dissociation and will pave the way to manipulating light-induced interactions to the solid-aqueous interface for improving the efficiency of light-to-energy conversion. These novel experiments will be performed for four nanoparticle photocatalysts, hematite, titanium dioxide, cerium oxide, and nickel-iron-oxyhydroxide with manifold electronic-structure properties (bandgap, charge carrier dynamics, and energetics), which make them attractive for future applications.

Keywords: photoelectron spectroscopy,solid liquid interface,transient species,