Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social networks and natural selection in changing societies (KinSocieties)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2499971.0
EU funding (EUR): 2499971.0
Participants: 1
Project status: SIGNED

Social interactions can improve support, resources and protection, but can also increase disease, stress and conflict. Consequently, for group-living species inc. humans, traits as diverse as personality, residence patterns, family-living and disease resistance all evolve in response to pros and cons of sociality. However, the direct links between sociality, health, fitness outcomes and ultimately natural selection are not well-known. KinSocieties reveals, for the first time, the benefits and costs of sociality accrued by individuals and whole societies in two complementary study species - humans and Asian elephants - facing current drastic changes in social structures due to break-down of kin networks. I use rare longitudinal data and two previously unstudied natural experiments to investigate effects of translocation to new social environments, addressed in 6 WPs: How have human social networks transformed with the modernisation of societies and associated with reproduction, cause of death and lifespan at different times? How does population structuring in humans affect reproduction, cause of death and lifespan? How does population structuring in Asian elephants affect reproduction, cause of death and lifespan? How is translocation to new area with/without kin or friends in humans related to subsequent integration, social networks, reproduction, lifespan and cause of death? How is translocation to new working units with or without kin, friends or social group in Asian elephants associated with stress, health, and friendship formation? Synthesize the costs & benefits of dynamic social structures in a modelling framework This research boldly combines approaches from social sciences, conservation, evolutionary demography and biology. The results have key theoretical and practical consequences, making also critical contributions to public health by revealing concrete costs and benefits tied to social relationships and their changes in the rapidly changing world of today.

Keywords: kin,social networks,societal change,family,natural selection,lifespan,health,reproductive success,infectious disease,human,asian elephant
Novel bipolar Membrane-Electrode Assembly designs for Simultaneous CO2 Capture and Reduction (BattleCap-CO2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Germany,Canada,Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-07-01
End date: 2028-09-30
Duration (months): 39.0
Total project cost (EUR): 303776.64
EU funding (EUR): 303776.64
Participants: 4
Project status: SIGNED

The discovery of efficient technologies for mitigation of the rising CO2 level and the associated energy and environmental issues is the grand challenge of our time. Electrochemical CO2 reduction (eCO2R) is one promising approach to convert CO2 into valuable products, but the practical realization is still limited by material and system-level challenges. On top of this, the pathway to bring CO2 captured from a point source to an eCO2R site involves energy-intensive, practically difficult intermediate steps often overlooked by the research community. The BattleCapCO2 project introduces a new pathway to fully integrate CO2 capture and CO2 reduction (CO2CR) in a unit flow reactor. This will be achieved by a unique design of bipolar membrane-electrode assemblies obtained by coupled 3D printing and photolithography techniques. An attempt will be done to elucidate the impact of BPM interface morphologies and electrode surface properties on the efficiency of CO2CR. The conceptual flow reactor design allows for simultaneous CO2 capture, in situ regeneration, and subsequent electroreduction into useful chemicals, presenting an energy efficient and cost-effective technological solution. The action will broaden the knowledge and expertise of the researcher through high-quality research training in the field of carbon capture and utilization, involving multidisciplinary investigation approaches and intersectoral secondments. This will allow him to expand his professional network with leading scientists in academia and industry from across Europe and the globe, and acquire key skill sets towards professional independence. The project will provide new technological solutions with a significant impact on the ambitious Europan green deal aiming to transform EU into a resource-efficient and competitive economy, ensuring a climate-neutral society.

Keywords: co2 capture,renewable energy,bipolar membrane,membrane reactors,microfabrication,integrated system,techno economic assessment
MINEYE - EARTH OBSERVATION TECHNIQUES FOR MINE LIFE CYCLE MONITORING USING ML-BASED DATA FUSION APPROACH (MINEYE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Sweden,Italy,Germany,Greece,Czechia,Belgium,Spain,Netherlands,Norway
Call: Earth Observation platform, products and services for raw materials (IA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6927477.45
EU funding (EUR): 5777167.78
Participants: 14
Project status: SIGNED

The MINEYE (Earth Observation techniques for MINe lifE cYclE monitoring using ML-based data fusion approaches) consortium consists of 13 partners from nine European countries and aims to strengthen EU autonomy in primary and secondary raw materials, at the same time as reducing environmental impact. This is done by development of innovative cost-effective, time-efficient and competitive Earth Observation (EO) based methodologies and technologies for the entire mining value chain. MINEYE will integrate EO data with other data sources such as EuroGeoSource, ProMine, EGDI and will collect new EO, remote sensing, geophysical and in-situ data. MINEYE aims at developing novel data fusion and processing algorithms for EO technologies for the mineral exploration, operational, closure and post-closure stages. MINEYE unlocks the potential of EO data, including Copernicus, commercial satellites, upcoming hyperspectral missions, airborne as well as in situ data. This is achieved by creating generic innovative machine learning algorithms tailored to solve specific needs within the mining value chain. MINEYE’s overall objective and ambition is to increase the access to critical and strategic minerals and metals in Europe with full consideration of environmental and social aspects, by providing the mining industry with proven and validated solutions for uptake of EO data and technology. MINEYE's final product is a web-interface, IPOP (Interfacing, Programming and Optimisation Platform) for providing data and result. IPOP has three outputs each covering a specific part of the mining value chain: (1) methods for Mineral Prospectivity Mapping (2) EO plugin for LiquidEarth software for 3D modelling, (3) evaluation and maps of re-mining potential and tailings characterization. In addition, ground stability assessment and environmental monitoring are included to support the development of a socially responsible mining. IPOP further serves as a multi-criteria decision-making tool.

Keywords: critical raw materials,mining value chain,earth observations,data fusion,artificial intelligence
Pre-CommerciAl ProCuremenT of Innovative Personal ProtectiVe Equipment for First REsponders (ACTIVE PCP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Pre-Commercial Procurement
Countries involved: Austria,Greece,Netherlands,Lithuania,Germany,Cyprus,Spain
Call: Demand-led innovation through public procurement (HORIZON-CL3-2024-SSRI-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 5249250.01
EU funding (EUR): 5249250.0
Participants: 10
Project status: SIGNED

The ACTIVE PCP project addresses critical shortcomings in Personal Protective Equipment (PPE) for first responders, aiming to enhance their safety, operational efficiency, and adaptability in the face of evolving threats, including Chemical, Biological, Radiological, Nuclear, and Explosive (CBRN-E) incidents. The project leverages the Pre-Commercial Procurement (PCP) approach to drive innovation in PPE, focusing on multi-hazard scenarios and integrating advanced features such as lightweight materials, ergonomic designs, health monitoring sensors, and GPS tracking systems. Key objectives include: (a) developing harmonised technical specifications through extensive stakeholder consultations; (b) encouraging supplier participation across Europe via open market consultations and matchmaking activities; (c) advancing innovative PPE prototypes through phased R&D, including design, prototyping, and pilot testing in real-life emergency scenarios across various EU Member States. The ACTIVE PCP initiative also emphasises compliance with EU safety and procurement standards, ensuring interoperability and cross-border applicability. The project fosters collaboration between public procurers, suppliers, and researchers, creating a robust ecosystem for innovation. Planned dissemination activities, such as workshops, training sessions, and publications, aim to maximise awareness and adoption of the project outcomes. Expected impacts include improved PPE usability and reliability, reduced costs through reusable and scalable designs, and enhanced responder preparedness and effectiveness in high-risk situations. Additionally, the project will strengthen the European industrial base by validating and commercialising advanced technologies, ultimately boosting EU resilience to large-scale emergencies and disasters. The ACTIVE PCP consortium consists of strong end-users and innovation procurement experts.

Keywords: personal protective equipment,first responders,cbrne,pre commercial procurement,innovation,emergency response
Diabetes: pericyte-orchestrated islet inflammation as a driver of beta-cell failure (PIIN_T2D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Type 2 diabetes (T2D) has reached epidemic proportions, killing millions each year; however, our incomplete understanding of its etiology hinders the quest for a cure. T2D is caused by pancreatic β-cell failure and insulin resistance. Recent studies point to aberrant islet inflammation as a driver of diabetes. While inflammation is beneficial for insulin secretion during homeostasis, it may transform to harm β-cell function and impair the glucose response. How islet inflammation maintains glucose homeostasis and why it converts to being destructive remain largely open questions. Here, I introduce a novel physiological mechanism, pericyte-orchestrated islet inflammation (PIIN), which is disturbed by diabetes risk factors to cause β-cell failure. To establish its requirement for β-cell function, we will first define the role of PIIN in homeostasis. We will then determine how T2D environmental risks, such as obesity and aging, hamper pericyte cytokine production and transform islet inflammation to cause β-cell dysfunction. Lastly, we will link T2D genetic risk factors with aberrant PIIN. To this end, we will analyze human and mouse tissues and use transgenic models to manipulate cells and genes to define the effect of PIIN on β-cell function. Ultimately, our findings will provide a mechanism through which T2D risk factors induce β-cell failure and promote disease progression. The implications of this project are far-reaching, as they will introduce a novel cellular mechanism that integrates metabolic and genetic risks to cause diabetes. Furthermore, our findings will implicate PIIN as a novel target for new therapeutic approaches to diabetes.

Keywords: pancreatic beta cells pericytes islet inflammation transgenic mice type 2 diabetes
Addressing the role of self-organization in tumor heterogeneity and plasticity (SelfOrg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: TERMINATED

Colorectal cancer (CRC) remains a major health challenge, with a survival rate of 15% in stage IV cases due to therapy resistance and tumor relapse. A key barrier to effective treatment is the high degree of intratumor heterogeneity and plasticity. These features enable the coexistance of diverse cancer cell populations within a tumor, each of them specialized in key functions such as proliferation, invasion or resistance to treatment. Additionally, phenotypic plasticity grant these cancer cells flexibility to dynamically tune their phenotype, to the extent that a single surviving cell can regenerate a full heterogeneous tumor. Despite their crucial role in CRC pathology, the biological mechanisms driving tumor heterogeneity and plasticity remain poorly understood. Current research suggests that tumor plasticity is driven by microenvironmental cues, where external signals induce specific cell states within localized tumor niches. However, my preliminary data reveal that cancer cells possess an intrinsic ability to self-organize and establish heterogeneity even in the absence of external signals. SelfOrg will tackle the unexplored contribution of self-organization to tumor heterogeneity and plasticity. To do so, I will combine quantitative measurements in bioengineered human organoids with physiologically relevant mouse tumor models to dissect the intrinsic mechanochemical signals regulating tumor heterogeneity. A systematic, image-based analysis of a patient-derived organoid (PDO) biobank will further assess the clinical implications of self-organization for patient prognosis. By leveraging my expertise in organoid mechanobiology and the host lab's proficiency in PDOs and translational cancer research, SelfOrg is uniquely positioned to address the problem of tumor heterogeneity from the novel perspective of self-organization. This innovative approach has the potential to uncover new therapeutic targets to improve survival and quality of life for CRC patients.

Keywords: organoids,mechanobiology,self organization
Deciphering immune evasion mechanisms of metastatic cancer cells using CRISPRa-inducible reporters (immunoMet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 262287.09
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

Most cancer patients are resistant to immunotherapies, especially patients with liver and bone metastases. This suggests that during metastasis, cells acquire additional immune evasion mechanisms that dictate susceptibility to immunotherapies. Current immunotherapies initiate T cell-mediated killing of cancer cells. However, combining them with agents that target other immune cells in the body, such as natural killer (NK) cells, may be more effective. Whether immune evasion mechanisms of metastatic cells differ between organs and whether these mechanisms can be targeted to improve immunotherapeutic strategies remains unknown. The first aim of this proposal is to leverage a molecular barcoding technique named CaTCH (CRISPRa tracing of clones in heterogenous cell populations) to search for new mechanisms of NK cell immune evasion. CaTCH enables tracing metastatic cancer cells in vivo and isolating clones in a barcode-specific manner for subsequent characterization and functional experiments. We engineered a human non-small-cell lung cancer model with a complex CaTCH barcoding library. Subsequently, we injected the cells into mice harboring NK cells and mice having no NK cells in an experimental metastasis assay. We identified several barcoded clones enriched in specific organs under immune pressure. I aim to investigate this dataset to find novel mechanisms of NK cell immune evasion in the metastatic environment. In the second aim, I will combine molecular barcoding with replicative history tracing of cells to identify cancer clones that evade immune-mediated dormancy in the metastatic niche. I will compare the transcriptional and molecular profiles of dividing cells high in abundance to dividing cells low in abundance to find novel mediators of immune-mediated dormancy. The successful implementation of these aims will uncover new immune evasion strategies of metastatic cells that will pave the way for novel immunotherapeutic strategies for cancer patients.

Keywords: metastasis,immune evasion,molecular barcoding,crispra
Cognitive and Neural Computations of Semantics (CONNECTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1496563.0
EU funding (EUR): 1496563.0
Participants: 1
Project status: SIGNED

In our everyday lives, we rely on existing relations among elements in our environment (i.e., semantic information) to interact efficiently with the world. This information can either be used to facilitate understanding by exploiting redundant (congruent) evidence or to signal out salient stimuli by highlighting unexpected (incongruent) elements. This duality raises fundamental questions about how and when our brains utilize stored semantic knowledge as its influence seems to vary depending on the specific cognitive domain. This seemingly paradoxical state represents a cognitive puzzle that questions whether the presence of (in)congruent contextual information in a given situation has a positive or negative impact on how we perceive, process, and remember information. CONNECTS seeks to address the paradoxical effects of semantic congruity across various cognitive domains by providing a unified framework. The proposed framework builds on the Transfer Appropriate Processing principle and brings it to a neural representational level. By examining the transformations of neural representations, it is possible to quantify the degree of overlap in cognitive computations as a measure of appropriate transfer. Thus, CONNECTS dissolves the paradox by proposing that performance would be optimal when the required cognitive computation is oriented towards the same stimulus properties emphasized by the semantic (in)congruity of the stimulus. This proposal not only reconciles conflicting evidence on specific domains but also provides a domain-agnostic framing of the conundrum that ensures its integrative aim. CONNECTS combines a solid theoretical foundation with cutting-edge neuroscientific techniques. The project's multi-method approach, including behavioural, neural (fMRI and EEG), and computational data from artificial neural networks. This approach offers a comprehensive exploration of the phenomenon which is a core requirement for a unifying framework.

Keywords: semantic congruity object processing scene processing memory encoding neuroimaging