Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Spatiotemporal regulation of T-cell Priming (STEP 2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1874425.0
EU funding (EUR): 1874425.0
Participants: 1
Project status: SIGNED

The initiation of adaptive cellular immunity requires antigen-specific interactions between Dendritic cells (DC) and naive CD8 T cells in secondary lymphoid organs. We aim to understand how the dynamic migratory behavior of myeloid and lymphoid cells is coordinated to ensure that “the right cells” communicate at “the right time” in “the right place” to enable robust immune responses. Using intravital microscopy, we have recently identified a critical phase (“Step 2”) of T cell priming that follows the initial encounter of DC and CD8 T cells and is essential to develop protective immunity. The aim of this proposal is to identify the cellular and molecular mechanisms regulating T cell differentiation during Step 2. We will employ a newly developed imaging method (“Net-Vis”) to investigate how key elements of Step 2 (XCR1 DC) receive antigenic and inflammatory “information” within a network of myeloid cells. Next, we will test a novel model of T cell priming in which stepwise relocalization to multicellular clusters within the LN orchestrates T cell differentiation. Combining deep-tissue intravital microscopy, “Niche-seq” and novel genetic approaches, we will identify the cellular players and molecules guiding these processes and test their mechanistic implications. Finally, we will investigate the identity and mechanisms of Foxp3+ T cells that co-regulate CD8 T cell activation and differentiation during Step 2. In summary, we will exploit an array of innovative imaging, spatiotemporal transcriptomics and genetic approaches to investigate novel fundamental aspects of CD8 T cell priming during a newly discovered distinct phase of T cell activation and differentiation. Investigating the mechanisms that guide these central steps in adaptive immunity is anticipated to reveal new avenues for the therapeutic manipulation of immune responses against infection and cancer.

Keywords: intravital microscopy,chemokines,viral infection,t cells,dendritic cells
Circular Processing of Seawater Brines from Saltworks for Recovery of Valuable Raw Materials (SEArcularMINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Ireland,Italy,Italy,Tunisia,Finland,Türkiye,France,Portugal
Call: New solutions for the sustainable production of raw materials (H2020-SC5-2019-2, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 5834016.25
EU funding (EUR): 5834016.25
Participants: 13
Project status: SIGNED

In this proposal, we build on the ancient and still widely used process of saltworks, where seawater goes through natural evaporation and fractionated crystallization in shallow basins. This process produces sea salt and a brine (bittern) free of calcium as a by-product, which is 20 to 40 times more concentrated than seawater in some crucial elements. The SEArcularMINE project uses this bittern, targeting Magnesium, Lithium and other Trace-Elements belonging to the alkaline/alkaline earths metals (e.g. Rb, Cs, Sr) or transition/post-transition metals (e.g. Co, Ga, Ge) group. Three innovative technologies will be developed and integrated within a circular approach, based on three different processes: 1) reactive crystallisation; 2) selective membrane separation; 3) selective sorption/desorption. The concept is enhanced by: i) energy-efficient concentration steps, ii) on-site generation of reactants from the available brines and iii) production of the required energy from reverse electrodialysis fed with the process outlet brine on-site and solar or wind energy. A multi-disciplinary approach will be adopted for bringing the low TRL of the three main technologies and of the overall integrated concept up to TRL4-5. There will be fundamental advances in the knowledge of the processes, leading to break-through developments of the 3 most important technologies for the recovery of minerals from brines, but also from seawater or any other kind of metals-rich solution. Within our circular strategy, we will look also at the option of including desalination upstream from the saltworks, providing freshwater to the local communities and a concentrated stream to feed the saltworks, increasing salt productivity and bittern availability. The adopted approach will have positive effects on the environmental and financial performance, laying the foundations for a future industrial application.

Keywords: circular economy,magnesium,lithium,alkaline and rare earths,transition metals,reactive crystallisation,electro selective membrane processes,ph swing adsorption
Development of novel rapid design methods for separation of enantiomers by crystallization: a process systems engineering approach (PharmaCrystEng)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 151850.88
EU funding (EUR): 151850.88
Participants: 1
Project status: SIGNED

Pharmaceutical industries face continuous challenges in terms of process development for new drug substances and product. Considerable amount of time and resources, both human and material, are spent on the engineering research, including the process, scale-up and control development for the promising molecules synthesized often in micro-gram scale firstly. Crystallization is a particularly important in the pharmaceutical industry as it links the drug substance (active pharmaceutical ingredient) and drug product (e.g. tablets, injectables etc.) manufacturing. Good operation of crystallization is not only important to achieve the desired yield, but the purity, polymorphism, chirality and also the particle size and shape strongly impact the performance of the drug product, e.g. the bioavailability, dissolution rate and, not rarely, the toxicity. Crystallization processes are currently being designed in pure experimental fashion, relying on the pharmaceutical Quality by Design (QbD), which undoubtedly moved and moves the pharmaceutical industry forward, but it has tremendous experimental burden. The digital era paws the way for competitive and often complementary computer aided process design techniques. The goal of this project is the development of novel process systems engineering methods that are suitable for rapid and robust-optimal crystallization process design. For experimental and simulation demonstration, to keep the simplicity without loss of generality, a challenging but frequently occurring pharmaceutical crystallization process will be considered: the preferential crystallization of enantiomers. For rapid experimental design, process analytical technology based feedback and feedforward control techniques will be developed as a direct alternative for QbD strategies. Multi-population balance models will be developed and applied for optimizing digital design as well as for scale-up and potential batch-to-continuous process transition analyses.

Keywords: population balance models,crystallization control,optimization,optimization driven experimental design
LeukoPredict: an in vitro system predicting and monitoring the therapeutic response of patients in the cure of Chronic Myeloid Leukemia (CML). (LeukoPredict)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic Myelogenous Leukemia (CML) is a blood cancer that affects every year more that 12000 patients in Europe and in the USA. Most CML cases are caused by Bcr-Abl, an abnormally active protein that confers tumorigenic capability to blood cells. The introduction of Imatinib, a Bcr-Abl potent inhibitor, revolutionized CML therapy, transforming this life-threatening cancer into a controllable disease. Approximately 30% of patients, however, display resistance to Imatinib and develop aggressive blood cancer. Here we propose a diagnostic kit (LeukoPredict) aimed to recognize resistant patients before the beginning of Imatinib therapy and address them to a personalized therapeutic alternative. Moreover, this test will be able to monitor the occurrence of newly acquired resistance after therapy initiation, allowing clinicians to prescribe only those drugs that demonstrate maximal efficacy. In the long run, we expect that LeukoPredict will become the gold standard to rationally define the CML therapeutic course, improve the survival of patients and limit the costs sustained by the healthcare system.

Keywords: leukemia,therapy,ce ivd,tyrosine kinase,bcr abl,imatinib
Mediation of stem cell identity and aging by proteostasis (StemProteostasis)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

By 2050, the global population over the age of 80 will triple. Thus, research for improving the quality of life at older age can be of enormous benefit for our ever-aging society. To address this challenge we propose an innovative approach based on a combination of stem cell research with genetic experiments in C. elegans. Mechanisms that promote protein homeostasis (proteostasis) slow down aging and decrease the incidence of age-related diseases. Since human embryonic stem cells (hESCs) replicate continuously in the absence of senescence, we hypothesize that they can provide a novel paradigm to study proteostasis and its demise in aging. We have found that hESCs exhibit increased proteasome activity. Moreover, we have uncovered that the proteasome subunit RPN-6 is required for this activity and sufficient to extend healtshpan in C. elegans. However, the mechanisms by which the proteasome regulates hESC function remain unknown. Our first aim is to define how the proteasome regulates not only hESC identity but also aging and the onset of age-related diseases. Moreover, one of the next challenges is to define how other proteostasis pathways impinge upon hESC function. We hypothesize that, in addition to the proteasome, hESCs differentially regulate other subcellular stress response pathways designed to protect them from disequilibrium in the folding and degradation of their proteome. We will perform a comprehensive study of proteostasis of hESCs and mimic this network in somatic cells to alleviate age-related diseases. Finally, we will determine whether loss of proteostasis promotes somatic stem cell (SC) exhaustion, which is one of the most obvious characteristics of the aging process and contributes to tissue degeneration. By using mouse models we will examine whether sustained proteostasis delays neural SC exhaustion. Our research will have an impact in several fields such as stem cell research, neurogenesis, proteostasis, aging and age-related diseases.

Keywords: proteasome,proteostasis,neurogenesis,cell reprogramming
Individual brain lateralisation, simulation of lesions, and stroke recovery – How the two halves of the brain interact: New insights from neuroimaging (PERSONALISED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death, and almost everyone will suffer neurological symptoms at some point in life. In Europe, stroke affects ~2 million people every year, a number that is dramatically increasing due to COVID-19 ramifications. Clinical presentation and neuroimaging can help confirm a stroke diagnosis, but both are limited in predicting recovery. The prediction is particularly challenging when a patient suffers from a stroke in one half of the brain (hemisphere) and recovers using the other hemisphere. Neurosciences have long been working under the assumption that each hemisphere is dominant for a different set of functions. For example, language is considered dominant in the left hemisphere, while visuospatial functions are dominant in the right hemisphere. However, this simple vision is challenged by stroke data. I propose to revisit the three guiding theories that explain how the hemispheres interact using recent developments in neuroimaging. The two hemispheres of the brain can either work 1) independently, 2) in competition or 3) in collaboration. It is now possible to test the three mechanisms using advanced neuroimaging and computational modelling and draw meaningful conclusions for precision medicine that will improve our ability to predict and aid recovery after stroke. In PERSONALISED, I anticipate that brain lateralisation mechanisms are dynamic, not the same for all people or across cognitive functions and may lead to different trajectories of recovery after stroke. Overall, PERSONALISED will decipher the mechanisms of brain lateralisation at the individual level, demonstrate the added value of advanced neuroimaging for the clinic and open a new avenue for research on the dynamic aspect of brain lateralisation.

Keywords: stroke,anatomy,asymmetry,lateralisation,brain,connectivity,neurology,tractography,diffusion imaging,cognition,personalised medicine,recovery,lesions,language,aphasia,attention
Time, Energy and security Analysis for Multi/Many-core heterogenous PLAtforms (TeamPlay)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Greece,France,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark
Call: Customised and low energy computing (including Low power processor technologies) (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 5123685.01
EU funding (EUR): 5123684.99
Participants: 12
Project status: CLOSED

The TeamPlay project aims to develop new, formally-motivated, techniques that will allow execution time, energy usage, security, and other important non-functional properties of parallel software to be treated effectively, and as first- class citizens. We will build this into a toolbox for developing highly parallel software for low-energy systems, as required by the internet of things, cyber-physical systems etc. The TeamPlay approach will allow programs to reflect directly on their own time, energy consumption, security, etc., as well as enabling the developer to reason about both the functional and the non-functional properties of their software at the source code level. Our success will ensure significant progress on a pressing problem of major industrial importance: how to effectively manage energy consumption for parallel systems while maintaining the right balance with other important software metrics, including time, security etc. The project brings together leading industrial and academic experts in paral- lelism, energy modeling/transparency, worst-case execution time analysis, non-functional property analysis, compi- lation, security, and task coordination. Results will be evaluated using industrial use cases taken from the computer vision, satellites, flying drones, medical and cybersecurity domains.

Keywords: low energy,timing,security,compilers,drones,space,computer vision,medical pill
Ground-Breaking Software for Sustainable Smart City Planning (ForeCast)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Public and private operators, who are developing services or infrastructures in urban areas, are confronted to growing complexity, which arises from diverse factors such as increasing urban population, new mobility trends, new consumption patterns or climate change. There is a strong need to provide these agents with decision-making support tools that continuously help them anticipate such challenges and optimise planning. ForCity’s software suite is a pioneer solution. Thanks to systemic prospective models, it simulates the impact of possible future city developments on the investments, showing the results in user-friendly 4D-maps and dashboards. It helps businesses and local authorities save millions of euros, reduce their environmental footprint and facilitate stakeholders’ collaboration, boosting the creation of sustainable Smart Cities. ForCity has already three applications in the suite, validated by clients and in use: ForCity DHC (to plan district heating and cooling networks), Water (to program drinking water networks) and Geoworking (to simulate human resources mobility policies). Three others are under development, in Mobility, Waste Management and Urban Planning. Only two companies in the world do a similar complex modelling and our solution is the only one that addresses multiple urban sectors (energy, water…), and delivers an online turnkey software. Smart City services represent a huge market (estimated at 175 bn€ in 2023) and planning tools are yet to be developed in this field, constituting a promising and lucrative segment. Since its creation in 2014, our French SME has experienced an outstanding growth (2.9 million€ turnover in 2017, 88 employees today, 20 French and International awards received) and our solution is already used in eleven cities. The present project will help us scale-up and accelerate our international expansion in our next targeted markets (Germany, UK and Hong Kong), reaching 46.5 million€ turnover and 214 employees by 2023.

Keywords: saas,decision making support,smart city planning,utilities,urban investment,sustainable planning,multisector,modelling,simulation,dynamic,systemic
Women, Men and Mobility: Understanding Gender Inequality in Prehistory (WOMAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-15
End date: 2022-09-03
Duration (months): 24.0
Total project cost (EUR): 175099.2
EU funding (EUR): 175099.2
Participants: 2
Project status: CLOSED

In the last years, the inclusion of gender perspective in Archaeology has had a strong impact, contributing to a deep transformation of the discipline in several aspects as hypothesis proposal, methodology or interpretation of results. Unlike other European or American countries, in Spain this renovation has not accomplished the same level of development, partly because of the scarcity of funding. Despite growing social interest, there is a major deficit in the knowledge we have about the origin of gender inequality. The way to inequality between men and women took place during the last phases of Prehistory, a period to which we approach mainly by Archaeology. Through this project, we aim to contribute to the advance in this research field, continuing a trajectory already started but from an interdisciplinary methodology which allow us to go further. Specifically, the project focuses on the analysis of gender inequality in Late Prehistory through the study of mobility. Social Anthropology and Ethnography studies poses a link between matrilocal residential patterns and more equality, on one hand, and patrilocal patterns and more inequality, on the other. It suggests that women mobility constitutes a relevant factor in the analysis of sexual inequality, opening the door to the proposal of hypothesis that connect such aspect to the origin of gender inequality in Prehistory. At the same time, in Archaeology, the study of mobility through strontium and oxygen stable isotopes allow us to approach to residential patterns in the past. Our aim is to combine both Social Anthropology and Archaeology in the study of Neolithic, Copper and Bronze Age, key periods in the study of social complexity, and to define better when and why women and men became unequal.
Polymer Optical Sensors for Prolonged Overseeing the Robustness of civil Infrastructures (POSPORI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-19
End date: 2023-07-01
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 1
Project status: SIGNED

The POSPORI project is dedicated to accelerating the deployment and use of polymer optical fibre Bragg grating (POFBG) sensing technology for prolonged overseeing the robustness of civil infrastructures. The two key research objectives are to develop optical fibre sensing systems to assess the stability of (i) reinforced concrete and (ii) reinforced soil structures, which are the key elements for safe construction in civil engineering. The project seeks to take a significant step beyond the current technology readiness level and enhance the creative and innovative potential of experienced researcher (Andreas Pospori) in the field of optical fibre sensors.

Keywords: polymer optical fibres,bragg gratings,sensors,structural health monitoring,reinforced civil infrastructures