Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breast cancer stem-like cells specific vulnerabilities: focus in HER2 over-expression and protein glycosylation (BCSC-ST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Breast cancer is the most common cause of female cancer death in Europe, hence it is urgent finding alternative treatments. A small population of cells that display stem cell characteristics has been described in breast cancer (BCSC) and linked to tumour progression, resistance to treatment and metastasis. New therapeutic approaches propose the use of stem cell targeting agents in combination with traditional chemotherapy. However, selective targeting of BCSC is still challenging as they are very similar to normal stem cells. Here, I propose to probe two characteristics that may be specific of BCSC: HER2 over-expression and altered protein glycosylation. I will use state-of-the-art technologies including the standardization of a new protocol to isolate Circulating Tumour Cells (CTCs) from blood, and the generation of a library of CRISPRs targeting all the genes related with protein glycosylation. After six years of postdoctoral stage in New York, I have wide experience in RNAi screens valuable for the library development. Supervised by Prof. Elliott at Newcastle University, I aim to learn the insights of protein glycosylation in cancer. The identification of BCSC specific vulnerabilities has important clinical implications as they represent outstanding candidates for new targeted therapies. Importantly, HER2 and protein glycosylation are mainly located in the surface of the cells, being accessible to targeting agents. The accomplishment of the proposal will contribute to my development as an independent researcher since I will: 1) gain knowledge in BCSC and protein glycosylation, fields with multiple functional implications; 2) generate data to use in my future projects, including a list of targeted therapies candidates; 3) standardize a method for isolating CTCs to further study breast cancer metastasis; 4) learn to use CRISPR libraries and generate a library with multiple applications; and 5) be trained and guided in the transition to a full autonomous position.

Keywords: breast cancer,stem cell,her2,protein glycosylation,crispr screen,circulating tumour cells,therapeutic target
Terabit/s Wireless Connectivity by TeraHertz innovative technologies to deliver Optical Network Quality of Experience in Systems beyond 5G (TERRANOVA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Finland,Greece,Greece,France,Portugal
Call: Networking research beyond 5G (H2020-ICT-2016-2, 2016)
Start date: 2017-07-01
End date: 2020-03-31
Duration (months): 33.0
Total project cost (EUR): 2996775.0
EU funding (EUR): 2996775.0
Participants: 7
Project status: CLOSED

To provide reliable connectivity of extremely high data rates in the Tbit/s regime and almost ‘zero-latency’ in networks beyond 5G, TERRANOVA proposes to extend the fibre-optic systems Quality of Experience and performance reliability to wireless, by exploiting frequencies above 275GHz for access and backhaul links. To this end, TERRANOVA will take advantage of breakthrough novel technology concepts, namely the design of baseband signal processing for the complete optical and wireless link, the development of H-band (>275GHz) RF front ends, as well as THz network information theory framework, channel and interference modelling in the THz regime, waveforms and high-order modulation schemes, pencil beam antenna arrays and multiple-access schemes and cashing techniques tailored to the particularities of the THz regime and the associated extremely large bandwidth. Sustaining a flexible and ubiquitously available Tbit/s access network in systems beyond 5G will require rethinking of design principles and architectures, mainly replacing the notion of joint optimisation with that of ‘co-design’, e.g. optical and wireless, backhaul and access, channel models and waveforms, signals and coding, beam-patterns and medium access schemes and so on. Most importantly, TERRANOVA will identify, assess and address the critical technology gaps and devise the appropriate enablers, expected to catalyse the road to beyond 5G. TERRANOVA innovations and technologies will be demonstrated by means of a Proof-of-Concept experimental platforms, validating and assessing the feasibility and performance of the THz wireless transceiver, the pencil beam based tracking and the co-design of fibre-optical and wireless principles. To realise this vision, TERRANOVA consortium brings together various stakeholders viewpoints and roadmaps from across Europe, an impressive record on research excellence and impact, technology innovation and transfer, implementation and demonstration expertise.

Keywords: tbit,s data rate,thz communications,fibre optic and thz wireless interface,baseband signal processing,rf frontend,channel modelling,signal and code design,pencil beam antenna arrays
Polynomial Optimization, Efficiency through Moments and Algebra (POEMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany,Germany,Italy,Norway,France,France,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 4015251.3
EU funding (EUR): 4015251.3
Participants: 11
Project status: SIGNED

Non-linear optimization problems are present in many real-life applications and in scientific areas such as operations research, control engineering, physics, information processing, economy, biology, etc. However, efficient computational procedures, that can provide the guaranteed global optimum, are lacking for them. The project will develop new polynomial optimization methods, combining moment relaxation procedures with computational algebraic tools to address this type of problems. Recent advances in mathematical programming have shown that the polynomial optimization problems can be approximated by sequences of Semi-Definite Programming problems. This approach provides a powerful way to compute global solutions of non-linear optimization problems and to guarantee the quality of computational results. On the other hand, advanced algebraic algorithms to compute all the solutions of polynomial systems, with efficient implementations for exact and approximate solutions, were developed in the past twenty years. The network combines the expertise of active European teams working in these two domains to address important challenges in polynomial optimization and to show the impact of this research on practical applications. The network will train a new squad of 15 young researchers to master high-level mathematics, algorithm design, scientific computation and software development, and to solve optimization problems for real-world applications. It will advance the research on algebraic methods for moment approaches, tackle mixed integer non-linear optimization problems and enhance the efficiency and robustness of moment relaxation methods. Specific applications of these approaches to optimization problems are related to smarter cities challenges, such as water distribution network management, energy flow in power systems, urban traffic management, as well as to oceanography and environmental monitoring and finance.

Keywords: optimization,semi definite programming,convex algebraic geometry,polynomial constraints,moments,sum of squares,real algebraic geometry
Evolving communication systems in response to altered sensory environments (CITISENSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

How animal communication systems evolve is a fundamental question in ecology and evolution and crucial for our understanding of adaptation and speciation. I will make use of the process of urbanization to address how communication signals adapt to changes in the sensory environment. I will focus on the impact of noise and light pollution on acoustic communication of Neotropical frogs and address the following questions: 1) How do senders, such as a male frog, adjust their signals to altered sensory environments? I will assess plasticity and heritability of signal divergence found between urban and forest populations of the tungara frog. 2) How do signals evolve in response to direct (via sender) and indirect (via receivers) selection pressures? I will expose forest sites to noise and light pollution, parse out importance of multiple selection pressures and carry out experimental evolution using artificial phenotypes. 3) What are the evolutionary consequences of signal divergence? I will assess inter-and-intra sexual responses to signal divergence between urban and forest populations. 4) Can we predict how species adapt their signals to the sensory environment? I will use a trait-based comparative approach to study signal divergence among closely related species with known urban populations. Our state-of-the-art automated sender-receiver system allows for experimental evolution using long-lived species and opens new ways to study selection pressures operating on animal behaviour under real field conditions. Our expected results will provide crucial insight into the early stages of signal divergence that may ultimately lead to reproductive isolation and speciation.

Keywords: signal evolution,urbanization,sensory pollution,anthropogenic noise,artificial light
Coherent Back-Lasing from Atmospheric Insects (Bug-Flash)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1499487.06
EU funding (EUR): 1499487.06
Participants: 1
Project status: SIGNED

I received I received the prestigious Inaba award by the lidar community for advancing lidar entomology. Our Scheimpflug lidar can be implemented at 1% of the conventional cost and weight. It allows atmospheric observation with unpreceded sensitivity and spatiotemporal resolution. The kHz sampling rates can exceed the round-trip time of the light and reveal the modulation spectra for classifying free flying insect species over ground. The method has infinite focal depth and efficiently profiles sparse organisms in the airspace with 100000 observations per day. This tool is of key importance for tackling challenges related to pollinator diversity, agricultural pests and pesticides and malaria disease vectors. As in radar entomology, in situ lidar monitoring apparently has inevitable limitations: 1) Detection limit deteriorate with range, and far observations are biased towards larger organisms, 2) It takes several wing-beats, and therefore time, beam-width and energy to retrieve a modulation spectrum for classifying species. I propose to remove range biasing and classify insects by a microsecond flash of light. Back-lasing in air has been a dream of physicists for half a century. I now intend to capture specular reflexes from flat wing membranes. When the surface normal coincides with the lidar transect, collimated back-propagating laser light is accomplished. This flash of light is spectrally fringed and can report on the membrane thickness for target classification purpose. This project has three ambitious milestones of increasing challenge with in situ campaigns: A) Polarimetric kHz lidar: Verification of specular flashes, investigation of range dependence, properties and likelihood. B) Remote nanoscopy: Spectral analysis of remotely retrieved flashes for membrane thickness assessment and optimization of back-scatter resonance. C) Farfetched flatness: I will enhance apparent surface roughness and collimated back-scatter from diffuse specimen by infrared methods

Keywords: atmospheric lidar,remote sensing,biophotonics,back lasing,thin films,nanoscopy,surface roughness,coherent infrared scattering,disease vectors,malaria,agricultural pests,pollinators,biodiversity
Electrostructural Tomography – Towards Multiparametric Imaging of Cardiac Electrical Disorders (ECSTATIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1475000.0
EU funding (EUR): 1186250.0
Participants: 3
Project status: CLOSED

Cardiac electrical diseases are directly responsible for sudden cardiac death, heart failure and stroke. They result from a complex interplay between myocardial electrical activation and structural heterogeneity. Current diagnostic strategy based on separate electrocardiographic and imaging assessment is unable to grasp both these aspects. Improvements in personalised diagnostics are urgently needed as existing curative or preventive therapies (catheter ablation, multisite pacing, and implantable defibrillators) cannot be offered until patients are correctly recognised. My aim is to achieve a major advance in the way cardiac electrical diseases are characterised and thus diagnosed and treated, through the development of a novel non-invasive modality (Electrostructural Tomography), combining magnetic resonance imaging (MRI) and non-invasive cardiac mapping (NIM) technologies. The approach will consist of: (1) hybridising NIM and MRI technologies to enable the joint acquisition of magnetic resonance images of the heart and torso and of a large array of body surface potentials within a single environment; (2) personalising the inverse problem of electrocardiography based on MRI characteristics within the heart and torso, to enable accurate reconstruction of cardiac electrophysiological maps from body surface potentials within the 3D cardiac tissue; and (3) developing a novel disease characterisation framework based on registered non-invasive imaging and electrophysiological data, and propose novel diagnostic and prognostic markers. This project will dramatically impact the tailored management of cardiac electrical disorders, with applications for diagnosis, risk stratification/patient selection and guidance of pacing and catheter ablation therapies. It will bridge two medical fields (cardiac electrophysiology and imaging), thereby creating a new research area and a novel semiology with the potential to modify the existing classification of cardiac electrical diseases.

Keywords: cardiac electrical disorders,magnetic resonance imaging,non invasive electrophysiological cardiac mapping,personalized diagnostics
Organic Charge Transfer Applications (OCTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Taiwan, Province of China,Poland,New Zealand,Russian Federation,Poland,Denmark,United Kingdom,United Kingdom,Japan,Brazil
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-10-31
Duration (months): 70.0
Total project cost (EUR): 1156500.0
EU funding (EUR): 832500.0
Participants: 11
Project status: SIGNED

Organic molecules are everywhere, they are integral to life, from every living species to new technologies such as organic electronics. Organic molecules can be made with infinite variety and what happens when they are excited by light is just as varied and complex. Molecular shape and molecular interactions are important in their application but what happens to them once excited is just as critical and often defines the function of that molecular within a more complex system. One of very interesting phenomena in organic molecules is electron transfer (ET) to form stable Charge Transfer excited states (CT). We may observe CT states everywhere, from living tissue to organic solar cells or organic light emitting diodes. It is believed that birds use CT states to navigate. It is therefore crucial to understand the ET process and the CT state. CT states, bound electron and hole pairs, separated in space on different parts of a molecules or different molecules play an ever increasing role in organic optoelectronic devices be they OPV or OLED or in bioimaging. Our OCTA project will form a new EU-Japan-Taiwan-Brazil network of leading groups and will train a new generation of materials scientists for the development and application of Charge Transfer based materials who can apply their expertise directly in future applications.

Keywords: charge transfer,tadf,photophysics,electrochemistry,synthesis
Structural characterization of immune signaling protein TIGIT using x-ray crystallography and cryo-electron microscopy (TCELLTIGIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The goal of this proposal is to obtain atomic resolution structures of TIGIT using X-ray crystallography and cryo-electron microscopy. TIGIT inhibits autoimmune responses, and anti-TIGIT antibodies can induce immune response in anti-viral and anti-tumor immunotherapies. No structures exist for the transmembrane (TM) domain of TIGIT, which is the portion of the signaling protein that transmits signals accross the membrane bilayer, and there are no structures of TIGIT bound to anti-TIGIT antibodies. High-resolution structures of full-length TIGIT and TM domain constructs will further our understanding of how TIGIT transmits signals across the cell membrane and modulates T cell activation. Structures of TIGIT TM constructs bound to PVR and anti-TIGIT antibodies will guide the design of anti-TIGIT drugs and antibodies for use in immunotherapy treatments. The candidate will carry out this structural work in the lab of Prof. Martin Caffrey, a world- renowned leader in the field of membrane protein X-ray crystallography.
Monolithic frequency comb spectrometers (MonoComb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Austria
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1498230.0
EU funding (EUR): 1498230.0
Participants: 1
Project status: SIGNED

Sensors are the heart of every smart technology. Capturing data of theSensors are the heart of every smart technology. Capturing data of the pollution in the air, infections of individual plants on a field, or our current physiological condition opens a variety of new possibilities. Cost effective and compact instruments that detect biomarkers in human exhaled breath have the potential to identify a number of severe diseases and various types of cancer. Optical sensors have the capability to realize such instruments that can be build into our mobile phones in future. The mid-infrared is the spectral region of choice, when it comes to sensing and spectroscopy, but mid-infrared technology is expensive, most components are bulky and often have a high power consumption. Monolithic integration and the possibility of large scale batch processing is a solution to overcome these limitations and to realize battery driven hand-held devices. Presently, integrated mid-infrared photonics rarely exists beyond theoretical concepts. This can be changed with this project by combining the best possible strategies to realize single-chip multi-species gas sensors. Fundamental research on frequency comb generation in quantum and interband cascade lasers will enable high resolution spectrometers without any movable parts. Optimized on-chip integrated photodetectors will allow ultra low-noise operation in or near the heterodyne noise limit even at room-temperature. Combined with on-chip integrated low-loss waveguides, extremely sensitive gas detection will be possible. Advanced stabilization schemes will enable ultra sensitive gas detection using compact low-budget electronics. All efforts are focused on the final goal to realize a miniaturized cost-effective tool to probe multiple biomarkers for breath analysis. Envisioning the early prediagnosis of diseases such as breast cancer, we particularly focus on the quantification of volatile organic components down to ppb concentration levels.

Keywords: frequency combs,quantum cascade laser,interband cascade laser,integrated photonics,mid infrared spectroscopy,lab on a chip