Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SEIMED support to enhance the innovation management of SMEs (SEIMED-INNOSUP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Spain
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 70000.0
EU funding (EUR): 56000.0
Participants: 2
Project status: CLOSED

Innovation support by the Enterprise Europe Network - SEIMED to enhance the innovation management capacity of SMEs in the regions of Comunidad Valenciana y Murcia. In order to enhance SME innovation management capacity, we will support SME´s to implement truly effective processes in order to become more competitive and have a pro-active attitude towards the changing business environment. The traditional approach to innovation is insufficient to make a qualitative leap in competitiveness and facilitate the renewal of the company. Our purpose within this programme is to implement an innovation management capacity in all the layers of the company, a reality that comprises all its activities and provide answers to the needs and challenges of the market. It is necessary, therefore, to create a system that could continuously generate innovation and not only erratic and sporadic progress. This service will be implemented as comprehensive seven-day service packages following the processes and guidelines that are laid down for this purpose. It will be delivered by suitably qualified senior innovation experts and be linked to the other support services of the Enterprise Europe Network SEIMED.

Keywords: sme innovation management,key account managment for the sme instrument,innovative smes with growth potential for internationalisation
Strong Field Dynamics of Atoms and Molecules: History-dependent Functionals and Exact Kohn-Sham Potentials of the Time-dependent (multi-component) Density Functional Theory (AMO-dance)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

In the "AMO-dance" project, the researcher, Dr. Elham Khosravi and the host supervisor, Prof. Angel Rubio, aim at deriving non-empirical history-dependent functionals for the time-dependent density functional theory to study the strong field dynamics of atoms and molecules. Furthermore, towards accounting for the electron-nuclear coupling and quantum features of the nuclear dynamics in molecules, AMO-dance proposes an in detail investigation of Kohn-Sham potentials of the multicomponent density functional theory. AMO-dance project will involve fundamental theory development, numerical implementation as well as application to real systems.

Keywords: strong field dynamics,time dependent density functional theory,multi component density functional theory,history dependent functionals
Synergy-based Open-source Foundations and Technologies for Prosthetics and RehabilitatiOn (SoftPro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Germany,Italy,Italy,Italy,Italy,Switzerland,Sweden,Netherlands
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 8675611.25
EU funding (EUR): 7440026.25
Participants: 14
Project status: CLOSED

Although much has been done for developing technologies to bear upon problems of individuals with sensorimotor impairments, the impact of robotic aids on people with real needs in the real world is still very limited. Our main goal is to increase the cumulative benefits of assistive robotic technologies to society by enhancing their effectiveness AND the number of beneficiaries. The challenge is to increase both multipliers in the “performance times accessibility” product, subverting the traditional situation where one factor can only be increased at the expense of the other. We believe this is possible by investigating how the artificial can physically interact and effectively “talk to” the natural. Understanding such a “language” is crucial not only to improve performance of rehab technology, but also to tackle the most difficult problem of making it “simple enough” to be effective and accessible. We possess good clues about such a language, whose words we believe are sensorimotor synergies, and have the scientific competence to further its understanding and the technological prowess to translate it into a new generation of robotic assistive devices. We know that a central ingredient for the applicability of synergy-based models to physical human-machine interaction is impedance adaptability, i.e. soft robotics technologies. We will develop soft synergy-based robotics technologies to produce new prostheses, exoskeletons, and assistive devices for upper limb rehabilitation. Building on solid methodological bases, this project will have a significant social impact in promoting advanced robot prosthetic and assistive technology, while introducing disruptively new, admittedly risky, but potentially high-impact ideas and paradigms, such as the proposed pioneering work on supernumerary limbs for assistance and rehabilitation to motor impairments of the upper limb.
Marine microalgae immunostimulant complex to boost the competitiveness of the EU aquaculture sector (ALGABOOSTER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The EU aquaculture sector is of high importance for the EU economy. However, EU aquaculture producers lag behind the global competitors that offer cheap products of much lower production costs and quality standards. In order to support EU producers in this highly competitive market, it is crucial to address their production inefficiencies: 20% mortality rates and long growth periods. The current solutions, namely use of antibiotics for mortality reduction and aquafeed with incorporated fishmeal and fish oil for improved growth, are inefficient, costly and extremely unsustainable. Consequently, there is a high need in the EU aquaculture sector for alternatives that can improve production efficiency in a sustainable, environmentallyfriendly and antibiotic-free manner. In this context, and basing on the excellent properties of marine microalgae, we have developed ALGABOOSTER - advanced aquafeed enriched with marine microalgae immunostimulant complex to boost fish immune system and growth as well as buffer the effects of stress, all in a natural way. The Unique Selling Points of ALGABOOSTER are: (i) whole-cell microalgae complex of high purity biomass of three marine microalgae species, (ii) perfectly-preserved microalgae ingredient ensuring thanks to a novel microencausulation process ensuring premium quality product, (iii) safe in use as the functional ingredient is incorporated into aquafeed (no risk of overdose), (iv) 100% non-animal and sustainably sourced (no fishmeal, no fish oil), (v) adjusted to support normal feed in two growth stages Our product has been scientifically tested and guarantees significant reduction in mortality rates and growth cycle duration as well as a substantial increase in quality of the final product. Via ALGABOOSTER´s administration, the production efficiency is enhanced, and aquaculture producers obtain a revolutionary increase in their profit margins.

Keywords: fish,microalgae,antibiotic free,immunostimulant,functional aquafeed,production efficiency,fishmeal,fish oil,antimicrobial resistance
Impact of Nanoplastics Pollution on aquatic and atmospheric Environments (NaPuE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy,Finland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1624751.0
EU funding (EUR): 849026.0
Participants: 2
Project status: SIGNED

Plastics pollution is ubiquitous and plastic debris have been found almost everywhere from the Alps to Antarctica, and even in the atmosphere. The size of individual plastic particles spans several orders of magnitude, and many of them are in the micro- and nanometre range. Nanoplastics (NPs) can be produced through degradation of larger plastic pieces, or they can directly enter the environment by incorrect disposal. Little is known about NPs in the environment, and their occurrence in the oceans has only recently been demonstrated. Due to their small size and large surface-to-volume ratio, the interactions of NPs with naturally occurring chemical species can be significantly different compared to larger debris. NaPuE will assess the environmental impact of NPs by determining how NPs can interact with abiotic components (e.g. oxidants, light, etc.) in seawater and in the atmosphere, and how these interactions can disrupt natural processes including seawater photochemistry and air-sea exchanges. The first part of the project will use laboratory experiments to determine kinetic constants and degradation products for NPs reactions with both sunlight, and chemicals species in seawater and in the atmosphere. The second part will focus on developing a procedure to collect and analyse NPs in the environment, which is crucial to assess their occurrence. Several approaches will be tested to this purpose, from mass spectrometry to aerosol measurement techniques. Finally, the reactivity of NPs in the environment will be modelled to evaluate their potential impact on natural photochemical processes, sea-atmosphere exchanges and the carbon cycle. We will provide exceptional insights into the reactivity and transformation mechanisms of NPs in the environment. Combined with the data about NPs occurrence, these results will be crucial to assess the environmental impact of NP pollution and will be decisive in developing strategies to solve the problems related to plastic pollution.

Keywords: plastic pollution,photodegradation,organic carbon,reactive oxygen species,interface reactions,methodology development,aerosol,trace gases
Quantifying the impact of climate change on orchid mycorrhizal symbiosis in Mediterranean biodiversity hotspots (FORECAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 277940.16
EU funding (EUR): 277940.16
Participants: 2
Project status: SIGNED

Compounded by habitat fragmentation and the pervasive impact of climate change, biodiversity, particularly in global biodiversity hotspots, faces an uncertain future. Orchids, among the most threatened plant groups in the world, have symbiotic associations with soil fungi in order to establish new individuals from seeds. Yet this important interaction between orchids and fungi is poorly understood in the context of rapid environmental change. The FORECAST project will provide a detailed investigation into the symbiotic relationship between a high profile orchid group of high conservation concern in Mediterranean habitats in Australia, the spider orchids, (genus Caladenia) and their fungal associates, using a combination of molecular, field, and physiological experiments. This will be used as a model system to predict the response of orchids to ongoing climate change and the resilience of these fungal symbioses in degraded and natural environments. Subsequently, during the incoming phase, the project will transfer the skills and perspectives learned from the outgoing phase and focus on members of European orchid Anacamptis in the Mediterranean. The fellowship will be hosted by Prof. Michael F. Fay at the Royal Botanic Gardens, Kew with a two year outgoing period at the Curtin University of Western Australia under the supervision of Prof. Kingsley W. Dixon, one of the world’s leading experts in the field of orchid ecology and conservation. I will learn state-of-the-art techniques for the study of orchid mycorrhizal fungi in Australia and transfer them to one of world’s leading botanic gardens and conservation centres, RBG Kew. This work will be facilitated by ongoing collaborations with the University of Naples Federico II. The ultimate goal of the FORECAST project is to develop new multi-faceted strategies for ongoing orchid conservation in Mediterranean habitats under climate change, thereby uniting conservation approaches in both Australia and Europe.

Keywords: orchids,conservation,climate change,mycorrhizal fungi
“Weathering and nutrient export from subglacial environments: A novel stable isotope approach” (ICE-OTOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-02
End date: 2017-11-01
Duration (months): 24.0
Total project cost (EUR): 183454.81
EU funding (EUR): 183454.80000000002
Participants: 2
Project status: CLOSED

The Earth’s surface has been dominated by cycles of glacial advance for more than two million years. Processes occurring at the glacier bed exert a fundamental control on the release of bioavailable elements to rivers and oceans and the evolution of the Earth’s surface, hydrosphere and atmosphere. As global temperatures rise and ice-sheets retreat, it is critical to constrain the roles that subglacial weathering processes play in controlling global biogeochemical cycles. The overarching goal of this project is to investigate the redox conditions that control vital nutrient and elemental release through a study of glacial outflows from contrasting subglacial environments. I will achieve this goal using a novel multidisciplinary framework incorporating cutting-edge redox sensitive stable isotope proxies (Mo, Fe and Se isotopes) of iron and sulphur cycling and oxidation state to unique glaciated regions. Using a combination of archived samples and focused field campaigns I will study subglacial outflow environments that differ in bedrock geology, regional climate and type of individual glacier drainage basins (e.g. ice cap, ice sheet and alpine glacier) in order to evaluate the importance of these parameters in weathering processes and ultimately the release of bio-available elements from the sub-glacial environment to rivers and oceans. Key questions I am to answer are how is the release of bioavailable elements a function of the redox state of the subglacial environment? Which of the three key parameters plays the most significant role? To what extent is this reflected in the enrichments of elements in solid/liquid phases? and how does this affect biogeochemical cycling downstream and nutrient supply?

Keywords: glacier,ice cap,subglacial,weathering,redox,iron,sulphur,stable isotope
Controlling the susceptibility of biological cells to pulsed electric field treatment by using ion channel modulators (EPmIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-11-05
Duration (months): 23.0
Total project cost (EUR): 155288.64
EU funding (EUR): 155288.64
Participants: 1
Project status: SIGNED

The integrity of the cell membrane, while essential for life of any biological cell, presents a barrier that sometimes needs to be transiently disrupted in order to deliver therapeutic molecules inside the cell. High-intensity pulsed electric fields (PEFs) are used increasingly in medicine to achieve such increase in cell membrane permeability via a phenomenon called cell membrane electroporation. PEF-based clinical applications include gene therapy techniques, DNA vaccination, electrochemotherapy, non-thermal tumor ablation, and cardiac ablation. Depending on the desired outcome of the PEF treatment, the targeted cells must either survive or die. However, different cell types exhibit different susceptibility to PEF treatment, with some cells being killed at lower pulse amplitude than others, which often presents a disadvantage that limits the safety and efficiency of PEF treatment. In this action I aim to design an approach that will allow us to increase or decrease cell’s susceptibility to PEF treatment in a controlled, clinically applicable way. The approach is based on using modulators of membrane ion channels, that can influence the extent and longevity of post-pulse membrane depolarization – a hallmark of membrane electroporation. My idea is on the one hand inspired by increasing amount of evidence showing the involvement of ion channels in PEF-induced cell response, and on the other hand by the fact that ion channel modulators are already successfully used in treatment of various diseases and we can expect exciting development of new modulators in the near future. The design will be guided by state-of-the-art microscopic techniques and computational models, including molecular dynamics simulations, particle-based simulations, and finite element modeling, that will help elucidate the molecular mechanisms of membrane depolarization and choose the appropriate modulators and pulse parameters for fine-tuning the treatment outcome.

Keywords: high voltage electric pulses,electroporation,voltage gated ion channels,molecular dynamics,particle based simulations,finite element method,in vitro cell culture experiments,cell viability
Evolution of fungal mating-type chromosomes (MatTypeEvol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Sex chromosomes often show extensive areas of suppressed recombination and cytological differentiation, a well-documented phenomenon in animals and plants. Lack of recombination is expected to limit the efficacy of natural selection, leading to degeneration in gene content. Similarly, fungal mating-type chromosomes, which are responsible for controlling compatibility during mating, can display patterns of suppressed recombination encompassing up to 90% of the chromosome length. The mechanisms responsible for lack of recombination and consequent degeneration remain unclear. Here, I propose to use comparative genomics to investigate the patterns and underlying mechanisms involved in recombination suppression and genomic degeneration in Microbotryum, a model fungal system with a range of dimorphic mating-type chromosomes. I will complement the currently available high-quality genome assemblies for twenty species in the genus with three outgroups, which will allow to polarize all genomic data. I will then use the genomic dataset to: 1) test hypotheses on the origin of recombination suppression in fungal mating-type chromosomes; 2) study the evolution of non-recombining regions in fungal mating-type chromosomes, e.g., their size and age, and the existence of evolutionary strata; and 3) study the patterns and mechanisms of genomic degeneration in non-recombining regions, namely non-synonymous substitution accumulation, transposable elements, disrupted genes, and non-optimal codon usage. Results will not only shed light on the origins and consequences of suppressed recombination and genome degradation in fungal mating-type chromosomes, but will also yield unprecedented insights into the dynamics of sexual reproduction in eukaryotes and contribute for a unified view of the evolution of dimorphic chromosomes.

Keywords: sexual reproduction,chromosome evolution,mating types,fungi
Exo- endocytosis cycle of individual synaptic vesicles in synapses and hemi-synapses (VesHemiSyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Neurotransmitters are released by exocytosis of synaptic vesicles at the presynaptic terminal. After exocytosis, vesicular components are retrieved by endocytosis for maintaining efficient synaptic transmission. The mechanism of vesicle fusion and retrieval has been subjected to intense interest but also fierce debate for the last 40 years. Several modes of synaptic vesicle cycling have been described that rely on distinct kinetics, associated proteins and spatial organisation of the exo- and endocytosis sites. Yet, the mechanisms underlying endocytosis initiation and coupling to exocytosis are still largely unknown because the detailed dissection of single vesicle recycling remains a major challenge. Using live imaging techniques and protocols to detect fusion pore opening directly, the fate of vesicle proteins at the plasma membrane will be monitored during synaptic vesicle cycling in synapses and hemi-synapses of cultured hippocampal neurons. I will test the relative contribution of each mode of exo-endocytosis during synaptic activity. Additionally, the favourable geometry of the new hemi-synapse model will allow high resolution mapping of the presynaptic exo- and endocytosis sites. Correlating the organization of exocytosis and endocytosis sites with the location of key proteins such as calcium channels and scaffold proteins will reveal the functional microarchitecture of the presynaptic nerve terminal. Overall, this project will provide new insights into the mechanisms of exo-endocytosis cycle of individual synaptic vesicles.

Keywords: cell biology,neuroscience,high resolution optical imaging,ph sensitive probe,hemi synapse,synaptic vesicle,exocytosis,endocytosis dynamics,presynaptic nerve terminal organisation