Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On the chemical origins of biological metabolism (MetabolismOrigins)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 2153020.0
EU funding (EUR): 2153020.0
Participants: 2
Project status: SIGNED

It has long been assumed that biological metabolism must have been an invention of life since its many reactions are catalyzed by enzymes, complex proteins that did not exist at life’s origins. However, my group and others have recently discovered that transition metals alone can mediate reactions of life’s most central metabolic pathways in the absence of enzymes (Wood-Ljungdahl pathway, glycolysis, parts of the Krebs cycle and reverse Krebs cycle, etc.). In contrast to ideas about the origin of life that focus only on genetics, this realization brings experimental support to a radically different vision in which biological metabolism arose from geochemical reaction networks, before enzymes or life itself, and created the molecules of genetics in the process. This proposal aims to find out how much of core biological metabolism might have emerged without enzymes and whether it could have given rise to genetics. I propose an experimental research program to identify conditions that would trigger the spontaneous emergence of metal-catalyzed versions of the biosynthetic pathways for sugar, amino acid and ribonucleotide synthesis. In contrast to approaches to prebiotic chemistry that need human intervention to direct their outcome and whose chemistries are very different from those used by life, this approach will aim, as much as is possible, for one-pot chemistry that is deeply rooted in metabolism. This tactic will ensure that what is discovered is likely to be relevant to life’s origins and even predictive about the way life operates today. This metabolism-guided approach to prebiotic chemistry will furnish deep understanding of how and why life’s biochemistry emerged and explain why it operates the way that it does today, rooted in fundamental principles of catalysis and organic chemistry.

Keywords: metabolism,systems chemistry,prebiotic chemistry,catalysis
The Roman Emperor Seen From the Provinces. Imaging Roman Power in the Cities of the Empire from Augustus to the Tetrarchs (31 BC-AD 297) (RESP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy,United Kingdom,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1998026.0
EU funding (EUR): 1634000.0
Participants: 3
Project status: SIGNED

This project will investigate the processes by which the representations of Roman emperors were created and disseminated from a new ‘peripheral’ perspective, which emphasizes the cultural, religious and artistic background of the local communities in the imperial provinces rather than the traditional ‘central’ one in Rome. It will study the ways in which Roman emperors were portrayed, celebrated and worshipped in the provincial cities, in the western and especially the eastern regions of the Mediterranean world, from the reign of Augustus to that of Diocletian (c. 31 BC – AD 297). By taking the point of view of the civic elites and of local artists in the provinces as the point of departure, the research will challenge the traditional ‘romanocentric’ approach to this subject to reassess imperial art and its broader ideological framework in a global context. It will provide the first comprehensive discussion on how the nature and significance of Roman power was interpreted and expressed on visual media in the provinces, and how it reflects the political and cultural strategies of the local elites. It will also challenge our perception and understanding of the relation between metropolitan and provincial production in imperial art by stressing the adaptation and independence of local visual culture from metropolitan canons. The research will consider all the media through which the imperial image was propagated, but will focus particularly on the comparative study of local coinage and local sculpture (both in the round and in relief representations). It will be informed by an interdisciplinary approach marrying classics, digital humanities and manufacturing studies. This will involve a new research methodology developed by the PI with the aid of project engineers and a 3D designer, which uses 3D imaging to compare, overlap and integrate the data provided by coinage and sculpture to trace and reconstruct models used in the provinces for imperial representation.

Keywords: roman empire,imperial provinces,roman imperial and provincial coinage,roman sculpture and portraiture,ancient visual and material culture,3d visualisation scanning and modelling,ancient techniques and technologies,art and craft production,dissemination and transfer of art and ideas
The international congresses and the transnational shaping of philosophy (1900-1948): Spaces – Struggles – Identity – Knowledge (INTERPHIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 255768.0
EU funding (EUR): 255768.0
Participants: 2
Project status: SIGNED

INTERPHIL analyses the construction of philosophy’s disciplinary identity by studying the first ten International Congresses in Philosophy (1900-1948), relating them to the emergence in Europe of a new academic space that aimed at unity across different schools of thought. Today, the still persistent cleavage between the “analytic” and “continental” ways of practicing philosophy, hyper-specialization and hyper-production suggest that the project of a philosophical unity was not achieved. The majority of philosophers currently acknowledge the uncontrollable pluralism of the discipline and have abandoned the dream of a transnational community aiming at collectively defining the discipline and at discussing its main advancements. Still, this dream had important consequences, as it fostered the emergence of institutional spaces of intellectual exchange. At the beginning of the 20th century, for the first time in history, the International Congress in Philosophy, organised, then supervised by a French group over almost fifty years, aimed at achieving this philosophical exchange and unity. The group of philosophers involved got progressively larger, and had to arbitrate disputes between different participants and include or co-opt subalterns or self-excluded European and non-European groups, such as those from Russia. How did these actors deal with the contradiction between ambitions of universalism and rising nationalisms? INTERPHIL adopts an inter-disciplinary and multi-scalar approach in order to explain the constitution of a transnational philosophical space, the formation of philosophical ideas of Europe and the participation of philosophers in international institutions such as the League of Nations. The approach is socio-historical: bibliometric, lexicographic, sociological, historical and philosophical.

Keywords: european union,global philosophy,analytic philosophy,continental philosophy,networks,bibliometry,encyclopedism
The transcription-related DNA damage response (TRANSDAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2499988.0
EU funding (EUR): 200000.0
Participants: 2
Project status: CLOSED

The cellular response to bulky DNA lesions, such as those induced by UV-irradiation, remains enigmatic despite decades of study. The effect of such damage on transcription is complex. At the local level, lesions cause stalling of RNAPII, resulting in a block to transcript elongation. Stalled RNAPII triggers transcription-coupled nucleotide excision repair, a process whereby lesions in genes are preferentially removed. Importantly, however, UV-irradiation also affects transcription genome-wide, so that even genes that are not damaged temporarily cease to be expressed. Alternative mRNA splicing also changes dramatically. The mechanisms and factors that underlie the global, damage-induced changes in gene expression, and its eventual normalization, are poorly understood. In order to facilitate identification of new factors and mechanisms involved in this response, we performed several distinct proteomic screens and an siRNA screen in parallel. This was complemented by characterization of transcription and mRNA splicing after DNA damage by genome-wide techniques. Any screening for new factors is high-risk, and the decision on which ‘hits’ to pursue is always difficult. Indeed, in any individual proteomic or genomic screen it is often impossible to distinguish ‘real’ hits from hundreds, if not thousands, of false-positives, and false-negative results are very frequent as well. Our multi-omic approach explores the same process from various angles and places less emphasis on hits from an individual screen and instead focuses on factors that score in several screens. This integration of screen results has resulted in the identification of several new factors and unexplored mechanisms. With a basis in exciting preliminary findings, this grant proposal thus describes a multi-disciplinary approach, including biochemical and cell biological approaches as well as proteomics and genomics, to characterize the transcription-related DNA damage response with an unprecedented scope.

Keywords: nucleotide excision repair,rna polymerase ii,cockayne syndrome,chromatin,proteomics
Stimulating the fusion of IoT and GNSS technologies (POINT.IoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Belgium,Bulgaria,Belgium,Portugal
Call: Awareness Raising and capacity building (H2020-SPACE-EGNSS-2019, 2019)
Start date: 2019-12-01
End date: 2022-05-31
Duration (months): 30.0
Total project cost (EUR): 983625.0
EU funding (EUR): 983625.0
Participants: 9
Project status: CLOSED

POINT.IoT combines the strengths of EGNSS with the growing importance of IoT devices in our daily life in a make-it-work approach, organised by leading companies in their field, such as Verhaert, SpaceTec Partners, Cesah and Orange. The POINT.Cheetah programme scouts and selects 20 new IoT applications using GNSS technologies for a combined 3-month technical and business sprint with a multidisciplinary team of mentors. Each selected application receives on average 80 hours of support. The business sprint ensures the maturation of the innovative usages of GNSS/IoT for investors, whereas the technical sprint is a combination of technical coaching and hands-on product development support. The programme focusses on a rapid development of 20 demos for early technical validation. The top-2 teams receive a prize of EUR 20,000 each. The POINT.Kangeroo programme supports the teams with business training tools. The POINT.IoT Entrepreneur Playbook guides the sprints that the teams and mentors undertake but can help any GNSS/IoT developer in a do-it-yourself sprint. The POINT.MOOC teaches the business basics in a modern and interactive manner with a Massive Open Online Course. Each year the POINT.IoT track at a leading investor event allows the top-5 teams to pitch their business to a panel of investors and corporates. The selected teams receive one-on-one investor readiness training to enhance their success rate. The POINT.Partnerships programme develops the narrative and guides the implementation of a partnership programme between POINT.IoT teams and industrial stakeholders as development partners, suppliers, clients or investors. The POINT.IoT Success & Inspiration Stories form the basis of discussion with GNSS/IoT stakeholders, and showcases successful GNSS/IoT solutions. The partnership matchmaking helps the POINT.IoT portfolio companies to have an easy access to leading IoT brands, for validation, partnering, business development or sales.

Keywords: egnss,technical sprint,business sprint,mentoring,proof of concept,demonstrator,mooc,investor event,iot development,business mentoring,technical mentoring,entrepreneur
Climate Change and Future Marine Ecosystem Services and Biodiversity (FutureMARES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Spain,Spain,Italy,Israel,Italy,Greece,Sweden,Sweden,Norway,Finland,Greece,France,France,Netherlands,Netherlands,Netherlands,Chile,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,Belize,United Kingdom,Portugal,Portugal,United Kingdom
Call: Inter-relations between climate change, biodiversity and ecosystem services (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 8555905.0
EU funding (EUR): 8555905.0
Participants: 36
Project status: SIGNED

Marine and transitional ecosystems provide fundamental climate regulation, food provisioning and cultural services. FutureMARES provides socially and economically viable nature-based solutions (NBS) and Nature-inclusive Harvesting (NIH) for climate change (CC) adaptation and mitigation to safeguard these ecosystems’ natural capital, biodiversity and services. The program advances understanding of the links between species and community traits, ecological functions and ecosystem services as impacted by CC by analysing the best available data from monitoring programs and conducting targeted experiments and beyond state-of-the-art modelling. Ensemble physical-biogeochemical projections will identify CC hotspots and refugia. Shifts in the distribution and productivity of keystone, structural and endangered species and the consequences for biodiversity will be projected within different CC-NBS/NIH scenarios to reveal potential ecological benefits, feedbacks and trade-offs. Novel, social-ecological vulnerability assessments will rank the severity of CC impacts on various ecosystem services and dependent human communities. Complementary analyses at real-world demonstration sites will inform managers and policy-makers on the economic costs and tradeoffs of NBS/NIH. These physical, ecological, social and economic analyses will be integrated to develop two climate-ready NBS and one NIH: i) restoration of habitat-forming species acting as ‘climate rescuers’ buffering coastal habitats from negative CC effects, improving seawater quality, and sequestering carbon, ii) conservation actions explicitly considering the range of impacts of CC and other hazards on habitat suitability for biota to preserve the integrity of food webs (e.g. marine protected areas) and protect endangered species (e.g. charismatic megafauna), and iii) Nature-inclusive Harvesting (NIH) (capture and culture) of seafood. FutureMARES is co-developed with policy-makers and managers to ensure impactful and transformative cost-effective actions.

Keywords: nature based solutions,vulnerability assessment,ecosystem services,economics,conservation biology,climate change adaptation,climate change mitigation,environmental policy
PexyEazy® - an innovative surgical device for treatment of haemorrhoids. (PexyEazy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Haemorrhoids is recognized as one of the most common medical conditions in general population, effecting up to 33% of the population under the age of 50 and up to 50% of the global population over 50-years old. Haemorrhoids are swellings containing enlarged blood vessels found inside or around the bottom (the rectum and anus). They occur when the rectal mucosa falls down from its normal position, causing problems like bleeding, soiling, itching and soreness, redness and swelling. Currently available treatments like surgeries are highly invasive and are associated with postoperative pain, high frequency of relapse, stenosis (narrowing of rectum), faecal or air incontinence and long recovery time (up to 1 month). In severe cases, surgery is the only option and modern surgical treatments focus on preserving and restoring the haemorrhoids, but they are still very expensive and not affordable for almost all population affected. Developeration has developed PexyEazy®, a novel medical device aiming to revolutionize the surgical treatment of haemorrhoids. The single-use, small (<26mm in diameter) device is based on a well-documented treatment method called mucopexy by which the haemorrhoid is lifted back to its normal position by applying running sutures in the mucosa above the haemorrhoid. This reduces the swelling of the haemorrhoid and the symptoms disappear. With PexyEazy®, haemorrhoid operations can be performed without the requirement of general anaesthesia, with less postoperative complications and in only 10 minutes, resulting in significant cost savings of 70% each procedure. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project, Developeration AB will conduct clinical trials with hospitals in Sweden, where they will initially market their product, along with scaling up for commercialization.

Keywords: novel treatment,cost savings,no side effects
Four-dimensional self-assembly from peptides and DNA (PepDNA-4D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-29
End date: 2021-07-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Structural organisation in living systems is both dynamic (varies with time), and emergent (more than the sum of its parts). Different blends of these aspects can be said to contribute to all the uniquely impressive processes of cellular biology. In contrast, synthetic self-assembled chemical systems rarely express each of these properties, being largely based on single self-assembly systems (e.g. DNA hybridisation or metal coordination), and static (i.e. observed at its thermodynamic minimum). This Fellowship will combine the Fellow's skills in chemoenzymatic peptide synthesis with those of the Supervisor in combining complementary self-assembly systems to obtain emergent superstructures. These studies will result in the first instances of dynamic and emergent self-assembly in synthetic chemical systems. To achieve this aim, we will perform chemoenzymatic polymerisation of peptides from the end of DNA backbones. Both units are capable of their own self-assembly - DNA through hybridisation, and peptides via secondary structures. In any 'static' snapshot of the system, the indirect interplay of DNA and peptide assembly will lead to highly unusual nanostructures. However, this work will go beyond, to measure the type and extent of self-assembly during the enzymatic polymerisation process using cutting edge techniques such as liquid-cell electron microscopy. The resultant systems will recapitulate the properties of living matter in these respects. In the course of these studies, the Fellow's professional skills will be honed through mentorship, the practice of taking a leading role in research, and through training courses offered by the Host Institution. At the end of the Fellowship, he will be ideally placed to assume an independent academic position.

Keywords: peptide,nanotechnology
Gradient NANOcluster Screening Arrays for SERS Analytics of Wound MicroBIOMEs (NANOBIOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This project addresses the quest for a new nanoparticle-based biosensing platform to study the chemical signaling within bacterial microbiome, bridging the gap from nanotechnology to biodiagnostic application. Healing-impaired and chronic wounds are a snowballing threat to public health and the economy. Their efficient treatment requires insight into the local wound microbiome, namely the composition and temporal evolution of bacterial communities. This project aims to provide access to the chemical cell-to-cell communication (quorum sensing, QS), which will enable monitoring changes in biofilms, specifically the competition of bacterial communities for resources and space, and the population density-depended change from non-virulent to virulent. To realize this goal, NANOBIOME will develop a plasmonic 2D screening platform for ultrasensitive surface-enhanced Raman scattering (SERS) detection of bacterial QS signaling. Contrary to other approaches, NANOBIOME will build on (1) well-defined self-assembled plasmonic nanoclusters, acting as sensing pixels; and (2) their ordered assembly on solid supports with defined inter-particle spacing - to avoid plasmonic coupling between pixels. Further modifications of the nanostructures will allow for facile tailoring of optical properties ideally suited for rapid screening for highest SERS activity. This SERS screening platform will grant quantitative insight into intra- and interspecies signaling to improve our understanding of bacterial competition in wound microbiomes using bacterial model systems (e.g., pathogens versus commensal bacteria).

Keywords: self assembly,surface enhanced raman spectroscopy,nanoparticle library,plasmonics,gradient material,bacterial biofilms,quorum sensing,metabolite detection,sensor