Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of an oral Helicobacter Pylori vaccine. (HELICOVAXOR)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Ireland,United Kingdom,Sweden,Czechia,Switzerland,United Kingdom
Call:  (FP7-SME-2012, 2012)
Start date: 2012-10-01
End date: 2014-12-31
Duration (months): 27.0
Total project cost (EUR): 1809000.0
EU funding (EUR): 1303000.0
Participants: 11
Project status: CLOSED

Helicobacter pylori infection is highly prevalent worldwide and is an important cause of gastritis, peptic ulcer disease, and significantly gastric cancer. Because eradication requires treatment with multidrug regimens, there exists a very strong need for a vaccine to prevent initial infection. Immunization with H pylori protein subunits in humans has shown adjuvant-related adverse effects and only moderate effectiveness. However, with much greater knowledge of the molecular basis of infection and having learnt lessons from previous vaccine developments, the current consortium have drawn together three strand that are considered critical to the development of an effective vaccine: - Powerful, safe and multivalent antigens - Powerful, safe and multi-acting adjuvants - Powerful, modular and flexible oral vaccine delivery system All three of the above innovative technologies have been proven to be effective in doing what they are required to do, namely: - Antigens – produce antibodies against a number of key H pylori bacterial components - Adjuvants – stimulate the immune cells to produce significant numbers of long lasting antibodies - Delivery – formulate antigens and adjuvants together and target the stomach and intestine This consortium (HELICOVAXOR) uniquely converges all three into a true vaccine with real potential to protect from H pylori infection. The vaccine is being designed for oral administration, efficacy, safety and temperature stability. This consortium has assembled leading academic, industrial and regulatory groups, the activities of which will be coordinated to perform analysis of the formulations, efficacy and safety testing of the vaccines and the preparation of a regulatory dossier, all required before the product can enter human clinical studies. If successful in pre-clinical studies, the consortium will work with vaccine companies to progress human studies and launch the product as a vaccine to confer protection from H pylori infection.

Keywords: helicobacter pylori,vaccine,adjuvant,antigen,protection,prevention,gastric cancer,regulatory,pre-clinical,convergence,integration,innovation
Thinfilm measurements on organic photovoltaic layers (THIME)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Spain,Finland,Germany,Austria,Germany,United Kingdom,Portugal
Call:  (FP7-SME-2012, 2012)
Start date: 2012-11-01
End date: 2014-10-31
Duration (months): 24.0
Total project cost (EUR): 1476807.0
EU funding (EUR): 1132677.7
Participants: 10
Project status: CLOSED

Printing and other large-area roll-to-roll (R2R)-compatible processes present exciting opportunities for cost-efficient mass manufacturing of electronics, among other functionalities, on large-area and flexible substrates such as plastic, paper and fabrics. In particular, thin film Organic Photovolactics (OPV) are generating a buzz in the industry. Printing the active components of a PV system onto flexible substrates means that solar cells could be incorporated onto a host of everyday objects, offing advantages in terms of weight, flexibility and low-cost production methods. A major challenge for the manufacture of polymer and printed electronics is the ability to control the layer properties more precisely than with conventional colour printing. The performance of OPVs is strongly affected by the thickness and uniformity of the needed layers. Accurate information about the thickness of the thin films being deposited would prevent the production of large volumes of materials that do not perform to the standards that they should. Without online thin film thickness measurements the real thickness of the R2R deposited layer can be measured only after the deposition process. The industry is in need of an online quality control method for thin film thickness on selected layers, which is vital for improved high quality, high volume, cost-effective production of such printed and large area electronics (OLAE) devices. The THIME project will develop a novel optical instrument for the on-line measurement of thin film thickness during the R2R manufacturing of these devices, which will be capable of measuring different OPV layers of differing characteristics values: thickness, refractive index, transparency and surface smoothness, and suited to a moving process (up to 10m/min) and is most likely not always in stable position in Z direction. No such detection method is available in the market and THIME will be a breakthrough for advancing the EU industry.

Keywords: hyperspectral imaging techniques,non-scanning white light interferometry
Injectable Medical Ceramics for Bone Repair and Augmentation (IMCOSS)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,Austria,Portugal,Switzerland
Call:  (FP7-SME-2012, 2012)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 2142500.0
EU funding (EUR): 1443000.0
Participants: 5
Project status: CLOSED

The repair and regeneration of bone tissue remains a significant clinical challenge in many clinical fields including orthopaedics, dentistry, and maxillofacial surgery. The problem is increasing in the face of complicating factors such as the ageing population. The aim of this project is to undertake a basic scientific study of new nanostructured biomaterials that will underpin the development of new nanostructured, injectable bone graft substitutes. This scientific and technological research will be integrated with the development of a dedicated advanced delivery system that will provide the surgeon with a high degree of control during clinical use. The basic scientific research will be directed at understanding structure-property relationships related to nanoparticle size and morphology, composition, and functional behaviour including rheology, biocompatibility, and bone tissue regeneration. While the project is ambitious, the likelihood of success is greatly increased by the formation of a consortium that includes different elements of the supply chain in combination with the scientific competencies necessary to execute the work programme. The scientific and technological aspects of the project will be further enhanced by the participation of a clinical panel composed of surgeons from the two RTD partner organisations. This combination of business, scientific and clinical expertise will together facilitate the translation of basic science through applied research and on to development of a new medical device.

Keywords: hydroxyapatite,injectable,medical device,bone repair,nanobiomaterial,orthopaedic,oral surgery.
Advanced cellulose packaging (ADCELLPACK)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Spain,Finland,Finland,Spain,United Kingdom,Spain
Call:  (FP7-SME-2012, 2012)
Start date: 2012-11-01
End date: 2014-10-31
Duration (months): 24.0
Total project cost (EUR): 1422822.2
EU funding (EUR): 1047990.0
Participants: 8
Project status: CLOSED

The use of bio-based materials is a promising alternative in the packaging industry to reduce the disposal and the use of non-renewable resources. A 5% substitution of these materials using Modified Atmosphere Packaging (MAP) applications would reduce over 300.000 tons of non renewable plastic packaging wastes disposal. Packaging used in MAP is usually based on multilayer plastic materials that are usually disposed as waste, approximately 300.000 Ton. ADCELLPACK consortium has identified that materials based in cellulose can be an outstanding alternative to substitute materials currently used in MAP. Changing consumer habits and motivations have benefited cheese consumption, and sliced cheese is an increasing market (>300kton/year), producing a huge quantity of packaging wastes. That is the reason for the selection of cheese as the fresh food product of ADCELLPACK. ADCELLPACK new solution will provide a readily thermoformable tray mainly composed of cellulose (up to 90% in weight), with improved properties using modified pulp fine fraction. However, it is needed a barrier layer in a porous, hygroscopic medium such as paper. To overcome this limitation, a blend based in polylactic acid (PLA) will be used. PLA lacks of the barrier to oxygen and water needed for modified atmosphere packaging. Therefore, to decrease costs and increase properties, blends with Polyglycolic acid will be considered to produce a coating and a lid for the tray. A whole sustainable solution that will maintain the freshness of the product and assure its food contact safety, will be developed by ADCELLPACK consortium, reaching a shelf life of 4 weeks.

Keywords: thermoforming,extrusion,blends,coated paper,map
Unlocking APTL’s Scientific and Technological Research Potential in Green Mobility (APT-STEP)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Greece
Call:  (FP7-REGPOT-2012-2013-1, 2012)
Start date: 2012-10-01
End date: 2016-03-31
Duration (months): 42.0
Total project cost (EUR): 1150921.4
EU funding (EUR): 1150921.0
Participants: 1
Project status: CLOSED

The objective of the APT-STEP project is to increase the research and innovation capacity of the Aerosol and Particle Technology Laboratory (APTL) of the Chemical Process and Energy Resources Institute (CPERI) of the Centre for Research and Technology Hellas (CERTH), a public non-profit research organization in the Region of Central Macedonia in Greece. Over the past decade, APTL has developed significant research result capital in the area of vehicle emissions control technologies; however, this technology area is maturing, and the automotive industry is turning to hybrid, electric and hydrogen fuel cell powertrain technologies in order to develop Green Mobility. APTL’s research capital has been built on core competencies in aerosol science, nanomaterials synthesis and characterisation, and hierarchically structured porous ceramic reactor engineering, which are also the foundation of the novel solar reactor technologies which the laboratory has also developed for the production of renewable solar fuels. These core competencies are also very relevant for the development of hybrid, electric and hydrogen fuel cell technologies, and, therefore, the objective of the project is to help APTL adapt its research and innovation capabilities to the new opportunities in these areas. At the same time, the Region of Central Macedonia faces significant air quality problems due to pollutant emissions in the transport sector, and, therefore, the project aims to increase the visibility of APTL to regional SMEs and public and private stakeholders in order to promote greater technology and innovation transfer. The project involves four highly experienced European industries and research organisations (Honda R&D Europe GmbH, AVL List GmbH, Centro Ricerche Fiat and CERTAM) with the objective to exchange know-how and experience and to establish long term strategic partnerships. Furthermore, an important objective of the project is the recruitment of experienced researchers with know-how in powertrain testing, new powertrain technologies, and product development. The acquisition of a chassis dynamometer and a constant volume sampler to enable complete powertrain testing will complement APTL’s existing engine test cell, and will enable the development of new powertrain technologies from lab scale to prototype scale.

Keywords: diesel emission control powertrain hybrid hydrogen fuel cell green mobility region central macedonia chassis dynamometer in-cabin air quality
Decision-making within cells and differentiation entity therapies (DECIDE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Ireland,Switzerland,Poland,United Kingdom,Poland
Call:  (FP7-PEOPLE-2012-ITN, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 3313022.02
EU funding (EUR): 3313022.02
Participants: 8
Project status: CLOSED

Our ITN has both scientific and therapeutic targets. Research in Work Package 1 (WP1) aims to advance understanding of normal blood cell development and why primitive cells fail to differentiate in acute myeloid leukaemia (AML). Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy. This type of therapy aims, using only mildly toxic treatments, to induce terminal maturation of leukaemia cells and accelerate their death. WP2 responds to the urgent need to devise milder treatments, especially for older and frailer AML patients. Participants have already identified a number of promising new therapeutic agents. Working across these two complementary areas will train our Early Stage Researchers (ESR) to understand the translation of new fundamental science into the development of new therapies. The ITN brings together scientists who have made important advances in the fields of haematopoiesis and differentiation therapy, so will provide an excellent scientific training in these areas. Secondments/visits by ESRs to participants who run centres of expertise in leading edge technologies will provide training in these; and the time spent with private sector participants, and the courses they provide, will ensure that ESRs acquire the transferable skills they will need if they are to work well in, and build bridges between, commercial and publicly funded research organisations. ESRs will also receive management training. This research and training, which will develop our ESRs as versatile scientists, will involve the combined efforts of prestigious research institutes and universities, Poland’s leading governmental pharmaceutical R & D institute, two successful biopharmaceutical companies and a leading management consultancy.

Keywords: haematopoiesis,haematopoietic stem cells,mesenchymal stem cells,cell decision-making,acute myeloid leukaemia,differentiation therapy,retinoids,vitamin d3,evaluation of drug candidates
Marine Energy Research Innovation and Knowledge Accelerator (MERIKA)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: United Kingdom
Call:  (FP7-REGPOT-2012-2013-1, 2012)
Start date: 2014-02-01
End date: 2017-07-31
Duration (months): 42.0
Total project cost (EUR): 4406017.53
EU funding (EUR): 3950000.0
Participants: 1
Project status: CLOSED

MERIKA (Marine Energy Research Innovation and Knowledge Accelerator) is an ambitious initiative by UHI (University of the Highlands and the Islands), located in Scotland and the UK’s outermost region. The project revolves around the concept of turning the UHI Faculty of Science, Health and Engineering into a reference research and innovation hub for all of Europe on the theme of marine energy. The region is endowed with a unique environment that enables research “where the resource is” for ocean wave, tidal and offshore wind power. Marine energy has the potential to meet a growing share of Europe’s energy demands in the years to come. Research is needed to improve predictability, forecast techniques and to provide equipment and instruments’ interactions to better manage development processes within a well preserved environment. UHI already has a consolidated position within the international research community and MERIKA represents the opportunity for a leap forward to acquire and reinforce its status of “reference centre” in Europe. The project relies on cooperation with 7 high profile scientific institutions in Europe and is centered on two main blocks of activities. One intervenes on capital (human and physical) and one builds capacity, especially in areas related to innovation and protection or exploitation of knowledge. The first block consists of: a comprehensive mobility programme with partnering organisations, a recruitment plan responding to precise needs for multidisciplinary competences to efficiently link different research strands, and a crucial upgrade in infrastructure, to enable UHI to function as the reference European hub for marine energy research. The capacity building component is geared towards a better use of complementary funds, the reinforcement of international collaboration and the definition of a coherent innovation policy to enhance UHI’s potential in its cooperation with industry and other stakeholders of the marine energy arena.

Keywords: marine energy,tidal power,ocean wave,offshore wind,environment
European Action towards Leading Centre for Innovative Materials (EAGLE)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-REGPOT-2012-2013-1, 2012)
Start date: 2013-06-01
End date: 2016-11-30
Duration (months): 42.0
Total project cost (EUR): 5529091.0
EU funding (EUR): 4953920.0
Participants: 1
Project status: CLOSED

The EAgLE project aims at establishing at the Institute of Physics, Polish Academy of Sciences (IFPAN) a leading multiprofile research Centre for designing and fabricating new materials, their characterization and testing under extreme experimental conditions. The Centre will identify and select novel materials, structures, phenomena, and computational protocols for functional new-concept nanodevices. The Centre will benefit from twinning with 16 partnering institutions having the sound expertise in the field of materials fabrication (e.g. MBE, chemical synthesis, lithography, FIB), characterization (e.g. XPS, TEM, EELS, synchrotron – diffraction and spectroscopy, NMR), nanodevice design and testing (e.g. semi- and superconducting electronics, cryogenics, computer simulations). The research potential will be enhanced through employment of both experienced and young researchers in the relevant fields. Within the project an X-Ray Photoelectron Spectrometer (XPS) will be acquired, making it possible to perform element specific and chemical sensitive characterization of materials with 3D resolution. A cryogen-free dilution refrigerator will be another essential purchase opening new opportunities to follow properties of the materials and devices down to a few miliKelvins. An important goal of the Centre will be exploration and standardization of user-friendly computational methods for materials design and for modelling of functional properties and nanodevices, including code validation and benchmarking, available also to external users. The awareness of issues related to the field of intellectual property, licensing, and patenting will be raised among the staff members via a series of dedicated workshops, in order to improve the transfer of innovations to new spin-offs, SMEs, and industry.

Keywords: innovative materials structural chemical physical analysis of materials design fabrication processing testing under extreme experimental conditions
FOSTERING AIMEN RESEARCH POTENTIAL IN LASER TECHNOLOGY FOR MATERIALS PROCESSING (FAIERA)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Spain
Call:  (FP7-REGPOT-2012-2013-1, 2012)
Start date: 2013-09-01
End date: 2016-08-31
Duration (months): 36.0
Total project cost (EUR): 1794180.0
EU funding (EUR): 1600688.0
Participants: 1
Project status: CLOSED

The Project “FOSTERING AIMEN RESEARCH POTENTIAL IN LASER TECHNOLOGY FOR MATERIAL MICROPROCESSING”, project acronym FAIERA, aims to upgrade RTD capacity of the Laser Processing Centre of AIMEN in the following Strategic Research Fields:  SRF1. Generation of multifunctional surfaces.  SRF2. Generation of biocompatible surfaces.  SRF3. Surface functionalization of textiles and fiber based composites.  SRF4. Laser induced structures for high efficiency semiconductor devices. AIMEN is already developing important research activities in the area of laser materials processing and is involved in different R&D projects in these fields. However, to reach its full potential for research and technological innovation, further development is needed. AIMEN has defined a plan which involves a coherent set of specific objectives and relevant actions in order to accomplish the strategic objective, utilize the strengths, and elude the threats as follows:  Establish strategic partnerships with experienced organizations in the scientifical and technological fields related to the Strategic Research Fields.  Increase human potential of AIMEN in laser microprocessing.  Increase technological potential of AIMEN in laser microprocessing and its applications.  Perform networking and collaborative activities with research centres of excellence.  Enhance AIMEN scientific visibility and international reputation through dissemination activities.  Elaboration of a strategic Plan for Intellectual Property management and protection and Innovation capacity building (IPI Plan). In the last decade, the technological requirements of traditional industry have evolved towards knowledge-based processes, high product differentiation, highly efficient processes and new materials. Besides, the market perspectives of AIMEN have been expanded to larger territories (Latin America) and industrial sectors (biomedical, aerospace, etc.). Laser is being a key enabling technology for accessing all these sectors. Regional stakeholders will participate through their inclusion in the Project Advisory Board, so that laser microprocessing could be one of the enabling technologies for the smart specialization in Galicia.

Keywords: key enabling technology,multifunctional surfaces,biocompatible surfaces