Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Children of the Barbaricum: Short Lives, Early Deaths on the Eastern fringes of the Roman world (CHILD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Children have vulnerability to morbidity and mortality, which in turn influence the social structures around these especially susceptible periods. The study of past childhood frailty and survival is still very much relevant today, especially for children from the “edges”. This project examines the health status of the Sarmatian children from the Barbaricum—the area beyond the Roman frontier. The written sources of classical antiquity paint the Sarmatians as nomadic people of the steppes between the Ural Mountains and Don River who migrated west and settled in the Carpathian Basin and on the Great Hungarian Plain, occupying parts of modern Romania and Hungary for over four hundred years. While the Greek and Roman authors described these populations as skilled equestrian warriors, hostile and destructive, caught in a cycle of war and peace with the Roman Empire, little is known about the biocultural challenges their children had to face living in the Barbaricum during the Roman Age. By utilizing interdisciplinary investigations, this project integrates data, models, and theories from bioarchaeology, archaeology, palaeoproteomics, growth and development, and ethnohistory in order to: deliver a life course approach to children’s health; offer a bio-culturally informed perspective on gendered differences in direct and structural violence; and reconstruct dietary habits at different life stages, as children transition into socially adult roles with the onset of puberty. According to the WHO, “Of the 5.2 million deaths that still occurred among children < 5 years of age in 2020, many were concentrated in vulnerable populations […]”. By adopting a life course approach within a biosocial framework, the project hopes to highlight how the past can inform the present and hopes to show how work carried on precious, ancient, tiny bones and teeth could contribute to the global efforts to improve the health and wellbeing of children and adolescents today.

Keywords: bioarchaeology palaeopathology diet late antiquity sarmatians
CO2 Fixation and Energy Conservation in the ancient Wood-Ljungdahl Pathway (Two-CO2-One)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1498863.0
EU funding (EUR): 1498863.0
Participants: 1
Project status: SIGNED

Carbon dioxide (CO2) receives a lot of attention as a greenhouse gas that promotes human-induced climate change. On the other hand, CO2 is also the starting point for the production of virtually all biomass on our planet. Therefore, nature has developed sophisticated methods to fix CO2 and make it available for biochemical reactions. Of all known biological CO2 fixation pathways, the Wood-Ljungdahl pathway (WLP) is the simplest way to fix two CO2 molecules to form acetyl-CoA, the key metabolic intermediate for biomass formation. It is the only pathway directly related to energy conservation and regarded to be the be the most ancient. The Two-CO2-One project aims to gain a comprehensive structural and mechanistic understanding of CO2 fixation and energy conservation in acetogenic bacteria and methanogenic archaea. These ecologically highly relevant organisms can live under conditions of extreme energy limitation in the absence of oxygen and feed exclusively on CO2 and hydrogen. I will elucidate how these species fix CO2 and conserve energy through their WLP by using the innovative structural approach of redox-guided cryogenic electron microscopy (Cryo-EM) to study the oxygen-sensitive metalloprotein machinery of the WLP. The mechanistic insights gained will be challenged by microbiological and genetic approaches in these anaerobic, non-standard model organisms. Using autotrophic organisms that can sequester gaseous CO2 to produce biogas or ethanol from abundant waste gas resources is one way to reduce the human carbon footprint. Therefore, the Two-CO2-One project will not only lead to a deeper understanding of the unique mechanistic principles of WLP, but also provide new perspectives for developing biotechnological applications based on improved microbes that capture and sequester CO2 to produce industrially relevant chemicals and to combat human-induced climate change.

Keywords: microbiology,anaerobic metabolism
Patient-centered care for vestibular disorders (PROVIDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Germany,France,Belgium,Spain,Austria,Denmark,United States,Sweden
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2897220.34
EU funding (EUR): 2663776.8
Participants: 24
Project status: SIGNED

Despite receiving little attention, vestibular disorders result in loss of vestibular (inner ear) function and create costly health disparities. One-third of the population experiences some form of vestibular loss (VL) that presents with a mix of symptoms, from dizziness to brain fog, that reduces both quality of life and workforce capacity, and, for unknown reasons, is more prevalent and disabling in women. For most individuals with VL, the underlying etiology is unknown, and management is insufficient. Due to its prevalence, disability, and poor management, VL results in aggregated costs likely exceeding €6 billion per year in Europe. To combat the burden of VL and address the need for innovation along the entire chain, from basic knowledge to new treatments, we mobilize an international team of 13 academic and 9 non-academic partners who unite specialized scientific and clinical expertise, advances in computing, device engineering and remote management platforms, and clinical and patient networks. We synergize these resources to deliver state-of-the-art training necessary for 10 doctoral candidates (DCs) to innovate the new tools (knowledge, approaches, and devices) essential to understand the etiology of VL, capture and interpret (characterize) the relevant symptoms of VL, and expand treatments to restore vestibular function. With collaborative impact activities, we additionally train DCs to enable diverse end users to adopt, use, and further innovate these tools and stakeholders to better advocate for future innovation. By training new leading experts, we aim to advance patient-centered care of VL and, moreover, reduce healthcare costs and promote sustainable “green” healthcare systems while also enhancing workforce and innovation capacity for individuals with VL and in the emerging academic, clinical, and industrial sectors focused on the care of VL. PROVIDE will be a model for future networks tackling challenges in healthcare and striving for health equity.

Keywords: vestibular disorder,inner ear,vestibular dysfunction,vestibular hypofunction,cochlear vestibular implant,sensory disorder,gait and balance,
PROSTarget: Understanding the aggressive nature and key molecular drivers of metastatic dissemination in lethal PCa. (PROSTarget)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: TERMINATED

Cancer cells dissemination from primary tumors to distant sites is the most terrifying evolving process of cancer. Such an irreversible and irreparable process encompasses tumor cells’ escaping, extravasating into blood stream and colonizing distant sites and is known as metastasis origin. Metastases spread is the leading cause of cancer-related deaths. The scattered but aggressive nature of metastatic disease and the extensive but not striking treatment effort history of metastatic cancers represents still a major obstacle in scientific progress and curability rates stemming from translational cancer research. Prostate cancer (PCa) hits men with high incidence and shows heterogeneity and resistance to standard of care. Altogether those hints imply that patients exhibiting disease progression, will head into complications succumbing to PCa-related high mortality, representing a major socio-economic problem world-wide. Importantly, PCa metastasis strikes after resistance acquisition to antiandrogens and taxols, overall limiting treatment efficacy. In this context, cancer research is vital with the aim of shedding new light on causal factors, unrevealing molecular mediators of the metastatic process, responsible for treatment resistance leading to patients’ poor overall survival. Finding those responsible mediators represents still an unmet medical need to reduce PCa mortality rate. Here we undertake an innovative translational approach to identify molecular cues underlying metastatic PCa. We focus our attention on a poorly characterized cancer entity: castration-naïve metastatic PCa , encompassing a tumor type that is metastatic at the time of first diagnosis. This tumor type is responsible for more than 50% of lethal PCa in the developed world. Through the project we will unleash prostate cancer vulnerabilities, to finally improve patient overall survival. For this reason, we built: PROSTarget

Keywords: cancer progression,metastatic cascade,metastasis,dormancy,prostate cancer,molecular drivers,aggressive,patient survival,therapy resistance,drug discovery,metabolism,
The Evolutionary Degeneration of Pollen in Asexual Dandelions (NoSexPoorPollen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Netherlands,Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 3
Project status: SIGNED

Dandelions (Taraxacum agg.) are one of the most important plants for insects, providing up to 80% of early spring pollen production in meadows. This high pollen production is surprising and unfavourable from the plant’s perspective as most dandelions reproduce asexually (apomixis). Decreased selection on nutritious pollen is therefore expected and would lead to lower production and degenerate (poor) pollen, or even complete male sterility, in the absence of sex. This would have potentially disastrous consequences for the dependent insects, especially in areas of higher latitude (e.g. Sweden) where sexual dandelions are absent. Little is known, however, about the evolutionary effects of asexuality on pollen production, particularly from a genomic point-of-view. We aim to understand how pollen degenerates under asexuality through a combination of phenotypic and genotypic characterisations in sexual and asexual dandelions, including male sterile plants: 1) microscopy and flow cytometry will reveal the effect of asexuality on pollen number, morphology and viability; 2) comparative transcriptomics in pollen, petals, bracts and leaves will reveal pollen-specific genes and if they are down-regulated under asexuality; 3) comparative transcriptomics in anthers will reveal genes necessary for healthy pollen production; 4) comparative genomics using full gene sequences will reveal the rate of deleterious mutation accumulation in pollen-specific genes, for which museum specimens will be unlocked using a customised Hyb-Seq approach. The fellow will fill significant skill gaps in their career through training in gene expression studies, whilst establishing themselves in plant reproductive biology. NoSexPoorPollen will be the first study to compare pollen gene expression in sexual and asexual plants. By combining phenotypic and genomic studies on pollen under asexuality, we provide an impactful and clear indication of the amount of insect food lost in the absence of dandelion sex.

Keywords: plant reproduction,asexuality,apomixis,pollination,adaptation,asteraceae,taraxacum,insect biodiversity,anthropocene,evolutionary ecology,herbariomics,museomics,hyb seq,flow cytometry
Innovative Self-healing Chalcogenide Catalysts for Green Hydrogen Production (INNOSHEAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

Electrochemical water splitting (WS) to produce hydrogen has been recognized as an up-and-coming technology for storing zero-carbon electricity generated from intermittent and non-dispatchable renewable energy sources. Among water electrolyzers, the emerging anion exchange membrane water electrolyzers (AEMWEs) are the most promising, combining efficiency and sustainability. Although it is an attractive technology, it is not yet mature and needs to be further improved to meet market needs. One of the main bottlenecks is related to the efficiency and durability of the WS catalysts. In this context, INNOSHEAL project (INNOvative Self-HEALing chalcogenide catalysts for green hydrogen production) aims to develop new WS catalysts, free of critical raw materials (CRM-free), highly efficient, and durable thank to self-healing groundbreaking properties. The innovative strategy is based on developing a design that allows for a large number of Fe-, Ni- and Mo-based catalytic active sites and an auxiliary system that promotes material self-healing due to the presence of a subnanometric layer of chalcogenide (S-, Se-, Te -based) sites. To ensure the successful achievement of project goals, the project will be conducted at ICB-CSIC, the Spanish National Research Council, with operando investigation during a secondment at PSI in Switzerland. The expected results of this proposal will primarily concern new knowledge on catalytic properties and self-healing characteristics, together with a contribution to the reduction of hydrogen production costs and the elimination of CRM dependency. The resilience of hydrogen-integrated energy systems is crucial for a reliable energy transition in Europe and will consolidate Europe's leadership in this field. Moreover, this project will help the researcher to enhance her academic profile and research skills, offering exciting career prospects while promoting new collaborations.

Keywords: green hydrogen,anion exchange membrane water electrolyzer,critical raw material free catalysts,hydrogen evolution reaction,oxygen evolution reaction,2d dichalcogenides
A European wide network of livestock advisors well embedded in their AKIS ecosystems and exchanging practical knowledge in the long-term for sustainable livestock production (LiveNet)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: France,Belgium,Bulgaria,Finland,Portugal,Romania,Croatia,Slovenia,Spain,Austria,Switzerland,Hungary,Greece,Ireland,Latvia,Netherlands
Call: Developing EU advisory networks on sustainable livestock systems (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 4103021.61
EU funding (EUR): 3770599.06
Participants: 20
Project status: SIGNED

The EU Farm to Fork strategy, which is at the heart of the European Green Deal, aims to make food systems fair, healthy, and environmentally friendly. Sustainable Livestock Production must play a substantial role to engage the EU in green transition while ensuring farmers’ incomes and quality of life. The main objective of LIVENET is to establish and build capacity of a network of advisory services across the EU, increasing the knowledge sharing between advisors, and among the whole AKIS, and the adoption of innovative solutions for Sustainable Livestock Production by farmers. The project will achieve this through: 1) the establishment and development of an EU network of livestock advisors, based on existing networks and national AKIS, covering the 27 EU Members States, the UK and Switzerland. To cover all MSs, the project will adopt a twinning approach: 10+1 National Networks will be created by the project partners and will engage with 18 Associated Networks through a twining program. The network will cover all European pedo-climatic areas, integrating 10 EU regional clusters, the major livestock sectors and the main thematic challenges faced by breeders; 2) the collection, selection, evaluation, adaptation and validation of context-based Innovative Advisory Practices (IAPs), which are technically, economically, socially, and environmentally viable and will be replicated across the EU, 3) the wide scaling of solutions through trainings, demo-events and other activities towards advisors, students and value chain actors to promote the adoption of the IAPs. 4) the connection with other regional, national and EU projects, initiatives and policy makers for better integration of livestock advisory organisations in the AKISs. The project embrace a multi-actor approach, gathering 20 organisations with a vast experience in advisory and sustainable livestock production representing a diversity of AKIS stakeholders (farmers, advisors, researchers, value chain actors).

Keywords: livestock,network,advisory,sustainable,adoption,innovation,practices,akis,green deal
Multifunctional and Sustainable Nanoarchitectured Networks for High-Performance Filtering of Air Pollutants (SuSCoFilter)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 139953.6
EU funding (EUR): 139953.6
Participants: 1
Project status: CLOSED

While 84% of the European population is exposed to dust concentrations above the WHO guideline limits, several epidemiological studies have established a strong link between exposure to indoor air pollution and adverse health effects. Commercial high-efficiency particulate air (HEPA) filters are inefficient in capturing particulate matter (PM) and toxic gases simultaneously. Their structural materials are also non-degradable and end up in landfills. As society demands a better future, and with an economic incentive, developing innovatively sustainable and efficient air filters is gaining ground in research and policy. The proposed SuSCoFilter project aims to develop brand-new sustainable air filters from spent coffee grounds (SCG) that possess unique multifunctional features such as simultaneous PM and SO2 removal capability, high efficiency, and low pressure drop. Effective removal of pollutants from the air can be achieved by introducing an advanced class of active hybrid porous materials (e.g. metal-organic frameworks - MOFs) to electrospun polymeric fibers. However, to develop a non-interfering “two-component MOF” system, two different surfaces should exist for each MOF component attachment. Proposed in SuSCoFilter microparticles of chemically modified SCG will provide the extra surface and the air filters will be produced by concurrent electrospinning and electrospraying methods. Set targets for capture efficiency of SuSCoFilter are PM10> 99%, PM2.5> 95%, and SO2>90%; and pressure drop<100 Pa. This interdisciplinary project has the capacity to advance basic science and technology in the field of green air filters and prompt the design of innovative SCG-based membranes for applications in water treatment, catalysts, gas separation/storage, and energy conversion. SuSCoFilter intends to convert a burdensome biowaste into a valuable resource material and strengthen the European circular economy and its sustainability.

Keywords: electrospinning,electrospraying,fibrous air filters,multifunctional materials