Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantitatively deciphering a novel metabolic pathway triggered by sulfide gas (Yeast H2S Signalling)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Gaseous mediators are ubiquitous in biology. For example, hydrogen sulfide (H2S) signalling leads to cardioprotective effects in humans and is believed to be beneficial for the mammalian gut microbiome. However, gaseous mediators in microbiology are under-explored because quantification of volatiles is challenging. Here, I will investigate how the volatile metabolite H2S can mediate cell-cell interactions and trigger a hitherto unknown sulfur metabolism pathway in Saccharomyces cerevisiae. Conventionally, Met17 is believed to be the only enzyme that can assimilate H2S (generated from inorganic sulfate) into organic compounds, and hence essential for growth on inorganic sulfur sources. However, I observed that the met17 deletion mutant can in fact grow on inorganic sulfate, albeit only at sufficiently high initial cell densities. My preliminary analyses suggest that H2S accumulates in met17- cultures, and when it reaches a threshold, enables cell growth by triggering an alternative sulfur metabolism pathway. In this proposal, I will 1) quantitatively understand how the alternative pathway responds to H2S by developing a mathematical model of density-dependent growth in met17- populations; 2) uncover the novel sulfur metabolism pathway in yeast by using transcriptomics and genetics; and 3) investigate the contribution of this H2S-responsive pathway to the fitness of wildtype yeast using population dynamics analyses. My research will not only offer mechanistic insights into how hidden aspects of yeast sulfur metabolism may contribute to cell-cell interactions and fitness, but also provide quantitative tools for studying gas-mediated microbial interactions from an interdisciplinary perspective. Finally, the project will extensively train me in the synergistic interplay between experiments and mathematical modelling — a style I hope to establish in my future, independent research.

Keywords: hydrogen sulfide,yeast sulfur metabolism,gaseous mediator,microbial interactions,density dependent growth,mathematical modelling,volatile metabolites
Euler systems and the Birch--Swinnerton-Dyer conjecture (Euler systems)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1070473.0
EU funding (EUR): 1070473.0
Participants: 1
Project status: CLOSED

The Birch--Swinnerton-Dyer conjecture, one of the Millennium Prize Problems, is one of the central unsolved problems in mathematics. It predicts a relation between the arithmetic of an elliptic curve and the properties of the L-function of the elliptic curve. Some special cases of the conjecture were proven by Kolyvagin; the main ingredient in his proof is an algebraic construction called an Euler system. Even though Euler systems are extremely powerful tools, so far only five examples are known to exist. I propose to construct several new examples of Euler systems, in order to prove new cases of the Birch--Swinnerton-Dyer conjecture. In particular, I believe the following theorem to be within reach: Let A be either a modular elliptic curve over a (real or imaginary) quadratic number field, or a modular abelian surface over the rational numbers. If the L-value L(A, 1) is non-zero, then the Mordell--Weil group of A is finite (i.e. the Birch--Swinnerton-Dyer conjecture holds for A).
Model theory of finite and pseudofinite structures (MODFIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The project is in model theory (mathematical logic), which concerns the expressibility in logical languages of properties of mathematical structures (e.g. graphs, groups, rings). Model theory aims to identify borders between `tame' and `wild' objects in mathematics, and to pin down abstract notions of independence and dimension and understand the geometry of `definable sets' in a structure, often with wide-ranging applications. This project focusses on classes of finite structures (e.g. the class of all finite fields), and on the `ultraproduct' construction which converts a class of finite structures to an infinite `pseudofinite' structure' which inherits properties of the class and is amenable to model-theoretic methods, with applications for the finite structures. Key objectives include: (i) proving a trichotomy for pseudofinite geometries -- they should be `trivial', `group-like', or `field-like'; (ii) developing current concepts from abstract model theory for pseudofinite structures; (iii) identifying first order properties of pseudofinite groups, and constraints on their possible quotients; (iv) finding links between the model-theoretic `independence theorem', Gowers' notion of `quasi-random groups', and the Szemeredi regularity theorem in graph theory. (v) model theory of finite ordered structures, and links to finite model theory. To support his future academic research career, the Fellow, Garcia, will receive training through research in the model theory groups in Leeds and (through a secondment) Lyon. There will be knowledge transfer to Garcia of expertise in model-theoretic algebra of Leeds and Lyon, and Garcia will also build knowledge of finite model theory and its computer science applications. He will receive complementary training in many research skills (including outreach), and will transfer to Leeds expertise he has gained in the excellent model theory groups in Berkeley and Bogota, while deepening EU-Colombia mathematics links.

Keywords: model theory,pseudofinite,group,combinatorics,finite model theory,o minimal,finite field,stable theory
5G System Technological Enhancements Provided by Fiber Wireless Deployments (5G STEP FWD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Spain,Greece,Sweden,Sweden,Greece,France,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-06-01
End date: 2022-03-31
Duration (months): 58.0
Total project cost (EUR): 3797921.67
EU funding (EUR): 3797921.67
Participants: 10
Project status: CLOSED

5G cellular networks are coming and they need to cope with major challenges in meeting the demands of large populations. The rapid increase of mobile devices, wireless connections and the emerging internet services related to applications with very diverse communication requirements (e.g., Smart grid, m-health, Smart cities), raised the need of higher capacity and more energy efficient networks with improved coverage capabilities. According to the 5G Public-Private Partnership (5GPPP) recently formed by the European Commission (EC), 5G networks should be capable of providing 1000 times higher capacity with 0% downtime, enabling the roll-out of very dense wireless networks that are able to connect over 7 trillion devices amongst 7 billion people. 5G STEP FWD aims at proposing, studying, optimizing, quantitatively assessing and comparing advantages and disadvantages of hybrid fiber – wireless architectures, topologies and technologies, which will significantly shape 5G standards and will enable the requested 1000 times increase of spectral efficiency and 90% reduction of energy consumption.

Keywords: mmwave,cell less architecture,wireless,optical,converged optical and wireless networks
The Psychological Origins of Trust-Based Cooperation (ORIGINSOFTRUST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2021-03-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Trust is essential for cooperation to flourish and for societies to function. While trust-based cooperation has been investigated extensively in fields as diverse as economics, philosophy, sociology, and psychology hardly anything is known about its ontogenetic and phylogenetic roots. The planned action will fill this gap and thereby make a significant contribution to the behavioral sciences. In a first step (outgoing phase), I will conduct innovative behavioral experiments with young children to uncover the developmental emergence of trust-based cooperation over the preschool years. Particular emphasis will be placed on the mechanisms by which children generate trust in cooperative interactions, how this is enabled by the development by key cognitive capacities (future planning, inhibitory control, theory of mind), and how this changes over course of development. In addition, I will conduct comparative studies with chimpanzees – one of human’s closest living evolutionary relatives – to elucidate the evolutionary origins of trust. By using cutting-edge experimental methodologies, the action will uncover the psychological foundations of one of the key proximate mechanisms underlying human cooperative activity and help reveal which aspects of trust-based cooperation are unique to humans. In a second step (incoming phase), I will apply the newly acquired knowledge to state-of-the-art decision-making research. By combining the strengths of two highly prolific research fields the action will generate fruitful theoretical synergies and provide new insights into how decision makers manage to overcome the social risks inherent in cooperative activities by selectively adopting a trusting attitude towards specific partners.

Keywords: trust,cooperation,decision making,development,evolution,children,chimpanzees
REGionalism And INstututional dynamics in the EU (REGAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The research project aims to investigate the formation of non-standard regions and the activation of multi-level governance practices induced by EU-led territorial cooperation instruments. It identifies four types of non-standard regions (micro, cross-border, off-shore and macro) that correspond to 4 EU instruments (CLLD, EGTC, maritime spatial planning, and Macro-regional strategy). They constitute a programmatic domain in which the EU is advocating a new regionalism agenda, which is based on the construction of new territorialised polities engaged in regional development and planning actions beyond formal administrative boundaries, from municipal to national ones. These new regional polities present an extensive variety of socio-institutional dynamics, committed to thematic or political objectives, and policy delivery channels. The scope of the project is to evaluate whether the tailoring of these regional polities contribute to address more appropriately socio-ecological regions, to activate cultural-cognitive understanding of new functional territories, to conceive more efficient spatial planning and development strategies. The project investigates one case-study region per each instrument, with a primary attention to two areas: a new micro-region and a cross-border region, which will be evaluated in relation to their overlapping/interaction with off-shore and macro-regions. Moreover, the fellowship poses the basis for a cutting-edge research program that explores the socio-cultural, political and institutional construction of these new territorialised polities; investigates their socio-institutional efficiency; makes explicit the characteristics of a renewed EU-led regionalism agenda; and clarifies the limits and the opportunities that a regionalism agenda on non-standard region has in addressing the challenges of contemporary Europe and its regional dynamics.

Keywords: regionalism,non standard region,territorial cooperation,institutionalism,clld,egtc,macro region,maritime spatial planning,european spatial planning,territorial polity,territorialisation
Twinning in atmospheric Plasma science and applications (TImPANI)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Germany,Cyprus
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 999625.0
EU funding (EUR): 999625.0
Participants: 3
Project status: CLOSED

The main aim of the project is to enhance the research capacity conducted at the Electromagnetics and Novel Applications Lab (ENAL) of the University of Cyprus (UCY) through targeted twinning activities with internationally leading research institutions, namely the Leibniz-Institut für Analytische Wissenschaften- ISAS-e.V. (ISAS), and University of Jaén (UJA) in Spain. In particular, the aim will be to stimulate excellence and innovation capacity at UCY primarily in the field atmospheric pressure plasma (APP). The focus will be on fundamental science on instrumentation and applications of the APP. The Twinning activities will include knowledge transfer, exchange of best practices between UCY, UJA, and ISAS, networking with research institutions and industry. The knowledge transfer will be achieved through in person training, webinars and PhD summer schools. The results and networking will be disseminated via participation at international and national conferences and also targeted events for the stakeholders. This project will entail significant benefits for all institutions involved in terms of enhancement of their Research and Innovation (R&I) capacity in science and technology and raising their staff’s research profile. It is expected that by the end of the project the consortium will have a core group of researchers (young and experienced) with considerable expertise in numerical simulations and modelling of APP, fabrication and characterization of APP and advanced mass spectroscopy with APP. The critical mass of researchers will be able to make a significant contribution to improving the research and innovation index of Cyprus. It is also expected that the Twinning project will lead to long-term collaboration between the three partners on joint proposals and projects, joint PhD students, infrastructure sharing and innovation through some of the novel applications that will be explored during the project.

Keywords: plasma jet,mass spectroscopy,organic,chromatography,numerical simulation
BioProtect Paper: Off-line machine for advanced bio-coating paper (BioPP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The barrier resistance and wettability of papers are commonly controlled by the application of petroleum- based derivatives such as polyethylene, waxes and/or fluor- derivatives as standard coatings for the industry. While surface hydrophobicity is improved by employing these polymers, they have become disfavoured due to poor recyclability limitations, and environmental concerns on generated waste with lack of biodegradation. Contrary to popular opinion, most coffee cups and similar disposables still aren’t recyclable! With all the attention over the past decade on recycling and doing right by the environment, the lowly coffee cup appears to have been missed in the push to make every form of packaging reusable or recyclable. Roughly 200 billion paper cups are used around the world every year, but none of those currently in use can be recycled without incurring prohibitive costs or greatly diminishing the At ORLOGA, we have developed an off-line machine for the smooth and versatile industrial implementation of a protective coating for paper/cardboard with +100% resistance to water and fully recyclable. BioProtect Paper project is a simple, rapid, and efficient hydrophobization of cellulose fibers through their reaction with gaseous TCMS at mild conditions (solvent-free + room temperature + no drying required). The off-line machine can be implemented at different stages of the value chain. Hence, paper mills, paper processors or even stand-alone business cases can be generated to transform standard jumbo rolls into waterproof jumbo rolls to deliver added value for the final paper processors. Th final products, being paper cups, specialty papers or other paper/cardboard packaging materials will continue with the recyclability of the initial jumbo roll. BPP reduces x1.5 the final price compared to laminated coating, which ultimately makes BPP the cost-efficient coating for cardboard and paper sheets.

Keywords: hydrophobic material,recyclability,biodegradable waste,no toxic material,plastic free
New Cluster Reactor to Deliver a Total Solution for PLD Manufacturing of Thin Films for 5G Technology (5G-TRAIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 1071087.5
EU funding (EUR): 749761.25
Participants: 1
Project status: CLOSED

The demand for advanced Radio Frequency (RF) components for 5G and basestations is rapidly increasing. Over the next 6 years there is a need for more than 100 billion Bulk Acoustic Wave (BAW) filter devices for 5G mobile. This translates in a >€100m market opportunity for Solmates’ PLD equipment in 2025. In addition, due to increased technical requirements such as new frequencies, there is a need for improved deposition technology for this emerging market. With PLD, Solmates has demonstrated over the last 2 years that these requirements can be met. However, it became also evident that High Volume Manufacturing (HVM) customers require a total solution in the form of a cluster tool at TRL8-9. To support this customer and market need, Solmates must expand and increase the functionality of its current single reactor PLD tool. The overall objective of the 5G-TRAIN project is to deliver a total solution for PLD manufacturing with better performance of advanced piezo thin films at 10x lower costs: these piezo thin films are critical for manufacturing of RF components such as BAW filters in the 5G market.For Solmates this market entry will be the stepping stone to the total >90 USD Billion8 semiconductor equipment market. The time to market is significantly lowered due to existing and new engagements with worldwide customers. The result of 5G-TRAIN will be a disruption of the 5G component manufacturing sector by realizing (for the first time) advanced thin film piezo materials at a commercially viable cost and scale. 5G-TRAIN will contribute to a leadership position in 5G (and 6G) for the EU industry, reducing dependency from US and China for critical communication technology.

Keywords: internet of things,customized robot and cleaner modules
Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics (AURORA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Switzerland,Belgium,Finland,Czechia,Netherlands,Netherlands,United States,United Kingdom
Call: Micro- and nano-plastics in our environment: Understanding exposures and impacts on human health (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 5996315.0
EU funding (EUR): 5996315.0
Participants: 12
Project status: SIGNED

The scale of micro- and nanoplastic (MNP) pollution is becoming increasingly clear yet little is known about how this pollution impacts health. The AURORA project will deliver an actionable European roadmap for early-life health risk assessment of MNPs to support regulation of MNPs and the products and processes that generate secondary MNPs, and development of safer alternatives. We will focus on MNP exposures and toxicological and health effects during pregnancy, in utero, and in early life. These periods are critical for development and health later in life and are of heightened vulnerability to environmental insults. We have recently shown that MNPs are likely to cross the placental barrier in vitro and in vivo, underlying the urgent need to understand the impact of MNPs on reproductive and early-life health. AURORA will do so by significantly enhancing exposure assessment capabilities for measuring MNPs and MNP-associated chemicals (e.g. additives) in tissues relevant for early-life development (placenta, cord blood, amniotic fluid, meconium, fetal tissue). It will take a unique approach by combining in-depth characterization methods (microscopy and spectroscopy) and scalable methods (mass-spectrometry) to develop methods for both detailed and large-scale toxicological, exposure assessment, and epidemiological studies. This will be combined with a novel tiered-testing approach and epidemiological investigations to provide the first extensive evaluation of maternal and fetal MNP exposures and health perturbations, including placental function, immune-inflammatory responses, oxidative stress, accelerated aging, endocrine disruption, and child development. In the course of developing and applying the tools and methodological workflows of the AURORA research program, we will create a risk assessment framework specific to MNPs and identify the remaining knowledge gaps and priorities needed for comprehensively evaluating the impact of MNPs on early-life health. AURORA is part of the European MNP cluster on human health.

Keywords: micro and nanoplastics,early life health,exposure and risk assessment,toxicology,microscopy,spectroscopy,mass spectrometry,placental function,immune response,homeostasis,child development