Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploring silencer functions via their associated chromatin factors (SIRENseek)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 299261.83
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

Distal regulatory elements in the genome play a key role in orchestrating tissue- and context- specific transcriptional programs. While activating elements (enhancers) have been broadly studied in the last decades, repressive elements (silencers) remain a ‘mysterious’ class of regulatory regions of the genome, whose characteristics have never been systematically elucidated. In the "seeking the SIlencer-associated REpressive protein Network” (SIRENseek) project, I aim to identify and functionally characterize silencers and silencer-binding proteins (SBPs) to gain insight into their mechanism of action and ultimately unlock their untapped potential for gene regulation and targeted therapy. To this aim, I will combine state-of-the-art proteomic analyses and high-throughput epigenomic profiling to identify SBPs and assess their relevance in shaping the chromatin landscape. First, I will focus on a repressive transcription factor known to bind silencers and I will use novel proximity labeling technologies to isolate its interacting proteins, thus unveiling other chromatin factors involved in silencer functions. Then, I will interrogate multiple candidate SBPs via a CRISPR screening and test their ability to rewire the chromatin landscape via ATAC-seq. Finally, by integrating this information with epigenomic data, I will identify SBPs with a functional role at silencers and test their ability to establish long-range chromatin interactions via 3D genomic approaches. Together, this interdisciplinary proposal will allow me to map for the first time silencer elements, their associated chromatin factors and the potential 3D interactions that they mediate to repress target genes, thus addressing the existing gap in our understanding of repressive elements.

Keywords: gene regulation chromatin silencers transcription factors epigenetic complexes
Residual executive power (REXPO). EU institutional balance and regulatory patterns after the Covid19 crisis (REXPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-16
End date: 2026-09-15
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

REXPO investigates shifts in EU regulatory practices following the Covid-19 pandemic. To contrast the pandemic the EU has mobilised unconventional legal tools such as financial assistance, cohesion policy or soft-law coordination, which fundamentally deviate from the community-method as the traditional EU law-making process. REXPO analyses the impact of this post-pandemic landscape on EU governance. Its central research question asks how the EU response to the pandemic has changed the nature of EU regulation and how new regulatory practices have affected the EU institutional balance in general and EU executive power in particular. The project focuses on the relationship between executive power and the unconventional regulatory instruments mobilised to face the crisis. It resorts to four empirical case-studies encompassing: the temporary recovery instrument NextGenerationEU, the unemployment financing scheme SURE, the distribution of vaccines, and soft-law coordination in the field of health policy. As these tools are all steered by the Commission, REXPO argues that they have strengthened the Commission’s executive functions, while moving away from the Community Method. Using a historical institutionalist lens, REXPO defines this increase in the Commission’s executive power as “residual”, because it emerged as a secondary result of choices necessary to fight the pandemic and not from an intentional attribution of competences by political leaders. REXPO combines empirical and theoretical research and adopts an innovative interdisciplinary approach to shed light on the legal and political consequences of the pandemic for EU governance and, eventually, for its democratic legitimacy. Whereas scholarship has focused on the political impact of the crisis and on the legality of the measures adopted, these interstitial institutional changes have passed unnoticed. However, precisely these changes can trigger a transformation of EU executive governance.

Keywords: nextgenerationeu eu law executive power eu institutional balance new modes of governance covid 19 community method historical institutionalism democratic legitimacy cohesion policy soft law
STRategies for Optimised bioprinting of Next Generation tissues for URethral regeneration and translation (STRONG-UR) (STRONG-UR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Denmark,Belgium,Finland,Italy,Netherlands,Türkiye,Sweden
Call: Bio-printing of living cells for regenerative medicine (HORIZON-HLTH-2024-TOOL-11, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 7811627.5
EU funding (EUR): 7811627.5
Participants: 12
Project status: SIGNED

STRONG-UR aims to revolutionise surgical tissue reconstruction by producing next-generation bioprinted tubular tissue constructs, focusing on urethral tissue engineering. Urethral strictures affect approximately 0.6% of the male population, leading to persistent physical and psychological impairment in patients and imposing a significant economic burden on healthcare systems. The lack of effective techniques to heal and repair diseased urethras emphasises the urgent need to invest in innovative regenerative approaches. In this direction, bioprinting offers promising prospects through the production of customised tissue constructs with controlled cell composition and architecture. However, there is still a significant gap between laboratory studies and clinical application, which is why there is currently no reliable technology available for clinical use. STRONG-UR includes the development of modular, scalable bioprinter components and bioinks to bridge the current gap. The bioinks comprise smart hydrogels customisable to personalised urethral constructs, supporting desired cellular functions and enabling non-invasive monitoring for real-time treatment assessment. Two different approaches are proposed: a single stage in situ bioprinting approach for accelerated clinical translation and a multistage approach using GMP-manufactured components to induce vascularisation and promote tissue healing. In addition, a novel bioprinted in vitro urethral model is proposed as a human-based testing platform for more ethical and reliable preclinical assessments. The project is in line with EU health policy, addressing unmet clinical needs and supports a Europe fit for the digital age. With a 12-partner consortium composed of scientists, clinicians, and companies contributing to the whole value chain, supported by a state-of-the-art infrastructure and a proven track record of successful projects in this field, STRONG-UR represents the best team to deliver this ground-breaking work.

Keywords: bioink development,bioprinting,biomaterials,biomaterials synthesis,tissue engineering,regenerative medicine,materials engineering,supramolecular chemistry,3d printing,biomedical materials
Post-National Reconceptions of European Literary History: A Mixed-Method Approach to a Late Medieval Text Tradition (Post-REALM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1873963.0
EU funding (EUR): 1873963.0
Participants: 1
Project status: SIGNED

The study of pan-European medieval literature faces two significant problems. The first is so obvious that it is rarely given much thought: only a fraction of the texts created in this period have survived. The second problem is similarly easy to overlook when working on any one text, which is that the content and reception history of those texts that do survive are usually studied separately within the ‘national’ philologies, whose linguistic and cultural borders make it difficult to gain insights into the broader patterns of creation, dissemination, and reception arising out of these fragments of cross-regional text traditions. At the same time, the linguistic and temporal limitations of analogue study make it all but impossible to gain a comprehensive overview of text traditions spanning different languages and large numbers of text versions. The interdisciplinary Post-REALM project will combine digital analysis with close reading and study of material context in order to focus on 26 versions of the late medieval pan-European 'Floire and Blancheflor' narrative. Drawing on a broad range of analogue and digital forms of analysis, we will develop and refine a new mixed-method template for how to approach widespread cross-lingual text traditions from the past. The aim of the project is not simply to create an entirely new understanding of how this popular late medieval narrative was written, adapted, and disseminated across different regions of Western Europe, but to inspire a step change in how the study of medieval literature is approached. Doing so will provide new conceptual frameworks and resource formats within which to relate the different surviving versions of historical text traditions to each other and new ways of understanding and visualising their contents, material context and paths of dissemination.

Keywords: mixed method digital philology,pan european medieval literature,material texts,manuscripts,close reading,stylometry,plot feature analysis,medieval romance,translation
Higher-spin symmetry and duality in (super)conformal field theory (HigherSpinCFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-08
End date: 2026-04-07
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Conformal symmetry is the maximal spacetime symmetry in relativistic quantum field theory. Such a symmetry is also realised in condensed matter systems at second order phase transitions. Conformal field theories possessing higher-spin and/or duality symmetries, along with their supersymmetric extensions, have recently been the focus of enormous interest worldwide. This proposal puts forward a research program to explore the dynamics and quantum aspects of such theories. Using recent advances in group theoretic formalism to compute correlation functions, the project aims to develop novel, manifestly supersymmetric techniques used for comprehensive analysis of three-point functions for conserved higher-spin current multiplets in superconformal field theories in Minkowski and Anti-de Sitter backgrounds – both playing pivotal roles in deciphering celebrated dualities between quantum field and gravity theories. Another goal is to study, for the first time, the quantum properties of the recently discovered Modified Maxwell (ModMax) theory. The latter is a unique non-linear extension of Maxwell's electrodynamics which is conformal and duality invariant. It has opened new avenues, all to be discovered, to study new classes of non-analytic conformal field theories. The project outcomes will advance our knowledge of scattering amplitudes and their relation to anomalies of superconformal field theories on curved backgrounds, while at the same time giving new insight into the field of non-linear electrodynamics. These results will be of major significance for a wide range of areas of modern mathematical and theoretical high-energy physics including string theory, gravity, cosmology and condensed matter.

Keywords: quantum field theory,dualities,conformal invariance,superspace,supersymmetry,higher spins,correlation functions
nOVel low-prEssure cRyogenic Liquid hydrogEn storAge For aviation. (OVERLEAF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Spain,France,Netherlands,Italy,Romania,Norway
Call: Greenhouse gas aviation emissions reduction technologies towards climate neutrality by 2050 (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 5951731.25
EU funding (EUR): 5951729.0
Participants: 13
Project status: SIGNED

In order to meet the objectives of the European Green Deal by 2050 in the aviation sector, the transition towards H2-powered aviation is the solution with the most potential. Although hydrogen-powered aircrafts exist, the current cost of storing and using H2 as a fuel in prolonged flights make their democratization impossible. The main blocking point is the absence of viable storage systems of H2 in aircrafts considering the strict limitations in terms of weight, volume, and cost-efficiency. A sensitivity analysis shows how the economics depend on the tank’s gravimetric index (GI). Today’s technology can barely achieve 20% GI for 500kg of H2, while industry actors need at the very least 35% GI for 500kg of H2 to transition towards H2-powered aviation. OVERLEAF intends to develop a game changer Liquid Hydrogen (LH2) storage tank to enable the transition towards H2-powered aviation. Based on a disruptive design (under patent process) and leveraging innovative materials and technologies, the OVERLEAF solution is expected to boast a GI higher than 60% for 500kg of LH2, with no venting over 24h. Furthermore, the concept is an enabler for using the aircraft’s fuselage as the outer tank, allowing to seamlessly integrate the tank in the aircrafts structure. OVERLEAF will have an interdisciplinary R&D approach focusing on advance materials engineering, testing and combination at lab and at pilot scale, together with appropriate simulation of different design architectures of the hydrogen storage system. The project will be based on three distinctive phases and implemented in 7 Work Packages. The consortium includes multidisciplinary partners from 6 different EU countries and contains all the necessary expertise and know-how to carry-out all tasks needed to achieve OVERLEAF’s ambitious objective.

Keywords: hydrogen,cryogenic,low pressure
Advanced multimodal marketplace for low emission and energy transportation (ADMIRAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Finland,Portugal,Spain,Slovenia,Germany,Lithuania,Greece,Italy,Croatia
Call: Logistics networks integration and harmonisation through operational connectivity to optimise freight flows and drive logistics to climate neutrality (HORIZON-CL5-2022-D6-02, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 9018823.75
EU funding (EUR): 7294412.14
Participants: 22
Project status: SIGNED

Freight transportation is responsible for large share of total GHG emissions in Europe. So far, majority of companies have concentrated on their primary emissions and those caused by their energy use, while indirect emissions from e.g. logistics services have received limited attention. It is obvious that a systemic socio-technical change is vital. The business models for sustainable sourcing and offering multimodal low-emission transport chains are missing. ADMIRAL project aims to have a systemic socio-technical approach. The vision of ADMIRAL is to change the mindset to take the emission level minimization as the main target by providing tools for companies. The main result is the Admiral marketplace, which manages the whole supply chain infrastructure and related emissions. It also works as a channel for developers to distribute innovative and sustainability-focused solutions in EU. The marketplace will be demonstrated and piloted by ADMIRAL partners in 4 pilots: Portugal-Spain, Slovenia-Croatia, Lithuania and Finland. ADMIRAL is focusing on the following objectives: 1) Evolve seamless operation within supply chains; 2) Enable better utilization of current assets and infrastructure to decrease emissions; 3) Embrace systemic change towards sustainability with sustainable sourcing; 4) Develop and pilot solutions that have altogether energy and emission reduction potential. The marketplace will also work as an innovation platform for new services, as software and solution developers have clear guidelines to include the invented services to be available in the platform. The marketplace will improve the value of the B2B logistic platforms. The B2C platforms are dominated by non-EU companies, e.g. Google, but the dominance for B2B platforms is yet to be determined. ADMIRAL will make contributions to the expected outcomes and impacts of the work programme e.g. by aiming to reduce emissions more than 20% and improving transparency and resilience.

Keywords: sustainability,logistics,digitalization,socio technical systems,platform economy,scope3 emissions,supply chain transparency,transport corridors,regulation,marketplace,artificial intelligence
Vital IntelliGence to Investigate ILlegAl DisiNformaTion (VIGILANT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Ireland,Germany,Slovakia,Moldova, Republic of,Spain,Estonia,Greece,United Kingdom,Bulgaria,Netherlands,Czechia
Call: Disinformation and fake news are combated and trust in the digital world is raised (HORIZON-CL3-2021-FCT-01, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 3725130.0
EU funding (EUR): 3376604.5
Participants: 19
Project status: SIGNED

Identifying, tracking and investigating online disinformation and other problematic content is an extremely complex problem. Many (European) Police Authorities (PAs) do not have access to any specialised tools or technologies to help them combat disinformation. Some of the better equipped PAs are using unsuitable off-the-shelf products that were designed to enable commercial companies to monitor social media chatter about their brands and products or to track the success of advertising campaigns. Such products are not capable of dealing with the complexities of disinformation nor do they provide advanced analysis tools and technologies tailored to the PAs needs. The VIGILANT project solves this problem. It is an integrated platform of advanced disinformation identification and analysis tools and technologies employing state-of-the-art AI methods which were developed as part of several highly successful FP7 and H2020 projects. They will be tailored to PAs use cases and needs, following an ethical-by-design and user-centric approach. In addition, social and behavioural aspects are also taken into account when designing tools and presenting results. VIGILANT covers disinformation from all major sources (e.g., major social media platforms, fake news websites), in all modalities (text, image, video) and in multiple languages. It is also suitable for investigating hate speech, violent nationalist or separatist movements, radicalisation, extremist groups, incels, loan wolfs, and other counter terrorism threats. The project also provides innovative solutions to leverage the knowledge and experience of other stakeholder organisations and (social) media companies. Finally, the project includes training for PAs in the use of VIGILANT and in conducting disinformation investigations as part of a long term sustainable training network. The interdisciplinary consortium includes expertise from social sciences and humanities, ethics, computer science commercial and four European PAs.

Keywords: detection,investigation,analysis,nlp,image and video forensics,social drivers and behavioural dynamics,ecosystem of tools,sustainable training and support networks for police authorities