Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
RNA silencing in regulation and evolution (REVOLUTION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: United Kingdom
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2013-12-31
Duration (months): 60.0
Total project cost (EUR): 2298433.0
EU funding (EUR): 2298433.0
Participants: 1
Project status: CLOSED

Small RNA is a specificity determinant of silencing mechanisms that can target RNA through base pairing to affect RNA stability and translation. This targeting process, directly or indirectly, can also target DNA and chromatin to introduce epigenetic modifications. In plants there are many hundreds of thousands - of different small silencing RNAs (sRNAs) produced from many thousands of loci. These sRNAs have enormous potential to influence genetic and epigenetic regulation because, from analysis of transgenes, it is clear that RNA silencing can have diverse effects. There can be RNA-mediated signalling between cells and complex interaction networks of RNA molecules with positive feedback and amplification loops. In addition there can be epigenetic effects that, once induced, can persist between generations. In REVOLUTION the aim is to find out which of the endogenous sRNAs have the various RNA silencing properties revealed by transgenes. The aim is then to integrate these findings into a systems level understanding of regulation and evolution in Arabidopsis. The role of these sRNA systems will be investigated in plants subjected to hormone and stress treatments. We shall also investigate the role of these sRNAs in natural variation between genotypes of plant and their effect in hybrids between these plants. In the final stages of the work it is intended to explore the various effects of endogenous sRNAs in plants other than Arabidopsis including tomato. This work will provide a new level of understanding of the mechanisms affecting gene expression in plants. This fundamental new understanding will affect crop science through conventional breeding and genetic engineering. In addition because RNA silencing takes place in animals including vertebrates there will be relevance of this work beyond plants.

Keywords: rna interference,transposons,signalling mechanisms
Gut immunity and homeostasis in Drosophila (GUTDROSO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Switzerland
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-04-01
End date: 2014-03-31
Duration (months): 60.0
Total project cost (EUR): 1485626.97
EU funding (EUR): 1485626.97
Participants: 1
Project status: CLOSED

The gut is the major interface between microbes and their animal hosts and constitutes the main entry route for pathogens. As a consequence gut cells must be armed with efficient immune defenses to combat invasion and colonisation by pathogens. However, the gut also harbors a flora of commensal bacteria, with potentially beneficial effects for the host, which must be tolerated without a chronic, and harmful, immune response. In recent years Drosophila has emerged as a powerful model to dissect host-pathogen interactions, leading to the paradigm of antimicrobial peptide regulation by the Toll and Imd signaling pathways. The strength of this model derives from the availability of powerful and cost effective genetic and genomic tools as well as the high degree of similarities to vertebrate innate immunity. However, in spite of growing interest in gut mucosal immunity generally, very little is known about the immune response of the Drosophila gut. Using powerful new tools and those developed in the study of the systemic response, we propose to raise our understanding of Drosophila gut immunity to the same level as that of systemic immunity within the next five years. This project will involve integrated approaches to dissect not only the gut immune response but also gut homeostasis in the presence of commensal microbiota, as well as strategies used by entomopathogens to circumvent these defenses. We believe that the fundamental knowledge generated on Drosophila gut immunity will serve as a paradigm of epithelial immune reactivity and have a wider impact on our comprehension of animal defense mechanisms.

Keywords: drosophila,insect,entomopathogen,mucosal immunity,gut,flora
Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology (MODELIST)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-06-01
End date: 2015-05-31
Duration (months): 72.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: CLOSED

Host-pathogen interactions have recently received much attention. Yet, a more comprehensive understanding of these interplays should provide fundamental advances in biology and help generating new therapeutics. The intracellular bacterium Listeria monocytogenes has emerged as an exceptional model organism to address key questions in biology such as actin-based motility, phagocytosis and post-transcriptional regulation. We will exploit our deep knowledge of Listeria and use this bacterium as a model to explore new landmarks in biology. In that aim, we will analyze several aspects of the infectious process, in a spatio-temporal fashion, at the bacteria, cell, tissue and host levels. Specifically, we will 1) search and analyze the function of new non-coding RNAs involved in virulence, and of new RNA-mediated regulations; 2) investigate new facets of bacterial entry and cell-to-cell spread in particular the role of uncharacterized cytoskeletal components, septins; 3) address the role of mitochondria and their dynamics in infection; 4) systematically analyze post-translational modifications during infection, starting with SUMOylation, a reversible modification and proteolysis, an irreversible one; 5) investigate chromatin remodeling upon infection; 6) characterize new virulence factors identified by their interaction with known signaling components or cellular sensors, by post genomics or by their effect on cellular responses analyzed herein ; 7) investigate further the intestinal phase of Listeria infection by analyzing in the germ-free transgenic mouse that we generated, the impact of commensals on Listeria (growth and transcription including non-coding RNAs) and on the intestinal tissue (histology and transcription of genes and microRNAs). Our main goal is to improve significantly our understanding of bacterial infections, by discovering important new concepts in microbiology, cell biology and infection biology thereby opening new avenues for further research.

Keywords: cellular microbiology
The humoral innate immune system: long pentraxins as a paradigm (HIIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Italy
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-06-01
End date: 2014-05-31
Duration (months): 60.0
Total project cost (EUR): 2066200.0
EU funding (EUR): 2066200.0
Participants: 1
Project status: CLOSED

The innate immune system consists of humoral and a cellular arm, but attention has largely been focused on cells and their receptors. The humoral innate immune system (HIIS) is generally represented as a collection of diverse molecules (collectins, ficolins, pentraxins). A tenet underlying this application is that in spite of molecular diversity, the HIIS is built on general principles and logic conserved in evolution. This general view will be put to a test capitalizing on the discovery by the applicant of the long pentraxin family, the prototype of which is PTX3. PTX3 is a multifunctional fluid phase pattern recognition receptor, highly conserved in evolution, at the interface between innate immunity/ inflammation and female fertility /matrix remodelling. The specific aims of the studies outlined herein are: 1) better define the repertoire of HIIS receptors by identifying new receptor(s) (eg PTX4) and ligands as well as interaction among receptor families (eg Ficolins); 2) pursue the structure and function of PTX3 as well as of newly discovered related molecules; 3) using genetic and cellular approaches define the relative importance of different cellular sources (eg lymphatic tissue); 4) based on 1-3, address fundamental mechanisms and logic in the interplay between cellular and humoral innate immunity; 5) explore the applicative potential of long pentraxins as diagnostics; 6) based on 1), engineer new pentraxins as potential therapeutics. The focus will largely be on unexpected turns, based on preliminary results, including: coupling of members belonging to different molecular classes; mechanisms of regulation of innate immunity (pathways of complement activation; P-selectin and leukocyte trafficking); the role in the extracellular matrix of lymphatic vessels.

Keywords: pattern recognition receptors,pentraxins,microbial recognition,complement,lymphatic vessels
Network in Advanced Materials and Nanomaterials of industrial interest between Europe and Latin American Countries of MERCOSUR (Argentina-Brazil-Uruguay) (EULASUR)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Coordination and support actions
Countries involved: Spain,France,Germany,United Kingdom,Denmark,Spain,Italy,Argentina,Uruguay,Brazil
Call:  (FP7-NMP-2008-CSA-2, 2008)
Start date: 2009-08-01
End date: 2012-07-31
Duration (months): 36.0
Total project cost (EUR): 1142525.21
EU funding (EUR): 999817.0
Participants: 14
Project status: CLOSED

A key thrust of FP7 is to promote international collaborative research with third countries. The EULASUR project will address the Call for Co-ordination Action in Materials by creating a cooperation platform for forming strategic research partnerships between scientists, policy makers, technology transfer and industrial experts in the EC and 3 Latin-American countries belonging to MERCOSUR: Brazil, Uruguay and Argentina (BRAU). Research topics will be identified within the fields of i) advanced functional ceramics and ii) hybrid materials and nanomaterials where significant opportunities exist for mutually beneficial actions between the two regions. The goals are designed to gain first hand knowledge of the state of the art research in these fields through summer schools, exchanges and partnership actions. The project will also address the social, political and cultural factors impacting technology transfer and collaboration between the EU and BRAU countries. The core activities of EULASUR are based on some research Groups of Excellence that already cooperate bilaterally and will integrate them with additional groups to generate a stable, integrated scientific platform of international excellence interested to collaborate in the development of materials research in specific topics of interest to both regions. The EULASUR partnership is composed of 15 research centres, 8 from Europe and 7 from BRAU countries selected on the basis of: excellence in research, complementary skills and access to national and international R&D policy makers. Government representatives will participate in the EULASUR Advisory Board. Industrial companies and technological centres are expected to take part in the project activities. EULASUR has 5 WPs. 3 designed to build contacts and identify opportunities, 1 to disseminate results to key stakeholders and policy makers and 1 management and progress measures. Each WP has two WP Leaders: one from BRAU and the other from the EU.

Keywords: advanced functional ceramics,hybrid materials and nanomaterials,international cooperation platform,road map,promote interactions,exchanges
Best Practices for IPR and Technology Transfer in Nanotechnology Developments (NANO2MARKET)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Coordination and support actions
Countries involved: Spain,Belgium,Germany,France,Spain,France,United Kingdom,Italy,Denmark
Call:  (FP7-NMP-2008-CSA-2, 2008)
Start date: 2009-07-01
End date: 2010-08-31
Duration (months): 14.0
Total project cost (EUR): 854327.79
EU funding (EUR): 689997.0
Participants: 10
Project status: CLOSED

The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging technologies, 2) Outstanding agencies for IPR advice, 3) Market analyst experts,industry associations and venture capitals, as end clients of IP. Constructing value chains of the transfer of each technology the consortium will analyse specific applications of the different areas of the nanotechnology R&amp;D European strategy: medical applications, information technologies, energy, materials, manufacturing, instrumentation, food, environment and security. Our objective is to classify the technology application areas of nanotechnology into different clusters according to: development costs, market time, complexity of licensing, etc. In parallel, a mapping of the technology and actual and forthcoming market will be analysed according to: competitiveness, geographical area, development potential, risks etc. Specific data mining tools will help to conclude the key worldwide actors of development and commercialisation of the different technologies. Also, actual IPR cultures and technology transfer rules will be listed according to the features of their market and technology. Matching these IPR technology transfer models with the concluded value chains and market and technology mapping, will allow concluding business models and setting efficient rules for technology transfer. All models will be discussed at consortium seminars, where general algorithms are expected to be excerpted. Specific guidelines will be given for research institutions and SMEs for efficient transfer of their prototypes to the market, along with a focus for the valorization of EU FP7 funded research projects

Keywords: nanothechnology,transfer,development,research,guidelines
Organisation of Manufuture implementation conferences 2008-2009 (MANUCONF08-09)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Countries involved: France,Sweden,Portugal,Sweden,France
Call:  (FP7-NMP-2008-CSA-2, 2008)
Start date: 2008-09-01
End date: 2010-03-31
Duration (months): 19.0
Total project cost (EUR): 785858.0
EU funding (EUR): 399500.0
Participants: 5
Project status: CLOSED

Promoted by the MANUFUTURE platform and the DG research of the EC, an annual conference is hosted since 2003 by the country of the EU presidency. The event objective is to report on the progress of the Manufuture activities and debate the future of the European manufacturing industry and the conditions for its sustained development. These events are fundamental contributions to the governance of research and innovation in manufacturing with a real added value to the industry through a progressive selection of complementary themes. These conferences have become a vital event for strengthening the programmes and actions by contributing to effectively identify and fill in the gaps in the R&D programme support in a multi-annual strategy. This project objective is to organise two events, in 2008 and 2009, in the direct continuation of previous ones. The 2008 conference will be held under the French presidency with a focus on how European SMEs and regional developments can efficiently contribute to the industrial implementation of Manufuture roadmaps. The 2009 conference under the Swedish presidency will highlight how this implementation should lead to a sustainable European manufacturing industry taking into account environmental and social issues. The project proposes follow-up activities to link the two events organised with an active involvement of the competent National Authorities. In France the Ministry of Economy Industry and Employment –MEIE has labelled the 2008 event as an event of the French presidency and delegated FIM and CETIM to organise it. In Sweden, VINNOVA, the Governmental Agency for Innovation Systems, is directly involved in the organisation of the 2009 event. This reflects the strong commitment and support of national authorities in this project. The EC, the Manufuture community (high level and support groups, 22 national and regional platforms) and the national key players in manufacturing will be deeply involved in the conference.

Keywords: manufacturing manufuture european technology platform conference nmp
Promoting real life Observations for Gaining Understanding of road behaviour in Europe (PROLOGUE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Netherlands,Greece,Austria,United Kingdom,Israel,Netherlands,Norway,Spain,Austria
Call:  (FP7-SST-2008-RTD-1, 2008)
Start date: 2009-08-01
End date: 2011-07-31
Duration (months): 24.0
Total project cost (EUR): 2462556.15
EU funding (EUR): 1999228.0
Participants: 9
Project status: CLOSED

The number of road fatalities in Member States is decreasing too slowly to meet the EU-targets. A new generation of measures is needed, underpinned by a new generation of research methods. Recent technology developments allow for this: naturalistic observations. This means that road user behaviour is observed unobtrusively in a natural setting for a longer period of time. This technique allows for analysing the interrelationship between road user, vehicle, road and other traffic in normal situations, in conflict situations and in actual collisions. Results will lead to a better understanding of road safety and help to realise an intrinsically safe road transport system, including in-car technology, self-explaining roads, driver training, etc. The main objective of PROLOGUE is to prove the feasibility and usefulness of a large-scale European naturalistic observation study. The project aims at road safety researchers and other stakeholders including car industry, insurance companies, driver training and certification organisations, road authorities, and governments. Whereas road safety is the main motive, the project will also look at the relevance for environmental issues, e.g. CO2 emissions, and traffic management. Based on inventory studies, a series of small-scale field trials, and close involvement of user groups and stakeholders, PROLOGUE will result in recommendations and an outline for a large-scale naturalistic study, dealing with research questions, methodology and technology for data collection, data storage, data reduction, data mining and data analysis. Communication and dissemination to all potential stakeholders are vital to gain their support for and involvement in a large-scale European study. The PROLOGUE consortium consists of 9 partners institutes, is well spread over Europe and includes Israel, has a wide experience on all aspects relevant for naturalistic observations, and a large international network of road safety and transport experts.

Keywords: intrinsic road safety,integration road user-vehicle-road,car drivers,high risk drivers,vulnerable road users
Design, Simulation and Flight Reynolds Number Testing for Advanced High-Lift Solutions (DESIREH)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Aeronautics and air transport
Action type: Collaborative project
Countries involved: Germany,Germany,Spain,France,Italy,Belgium,Netherlands,Germany,Italy,Sweden,France,Russian Federation,Germany,Italy,France,Germany
Call:  (FP7-AAT-2008-RTD-1, 2008)
Start date: 2009-03-01
End date: 2013-06-30
Duration (months): 52.0
Total project cost (EUR): 7078825.0
EU funding (EUR): 4992335.0
Participants: 21
Project status: CLOSED

DeSiReH focus on both, the numerical design tools and the experimental measurement techniques for cryogenic conditions, with the objective to improve the industrial design process for laminar wings in terms of product quality, efficiency, and development cost reduction. The work focuses on the design of high lift devices. DeSiReH addresses the following quantified objectives which will make a significant contribution to meeting Vision 2020 goals: 1) Reduction of industrial A/C development costs by 5% by reduced and more efficient Wind Tunnel Testing 2) Decrease time-to-market by 5% by improved aerodynamic design turn-around time 3) Improve industrial High-Lift design process efficiency by 15% 4) Reduce A/C drag by 5% by enabling NLF though compatible High-Lift-Design To accomplish these objectives the project is planned for a period of 4 years and a budget of 7.6 Mio. Euro. The consortium consists of 6 industry partner, 7 research establishments, 3 universities, 2 small and medium-sized enterprise and the European Transonic Wind tunnel (ETW). Existing and validated high-fidelity numerical tools are composed to an efficient High-Lift design and optimization process chain in WP1. The strategies and tools developed are applied in WP 2 to the aerodynamic design of a high lift system for the future pointing HARLS wing (High Aspect Ratio Low Sweep) with the constraint to maintain Natural Lamiar Flow at cruise to the best possible extend. WP 3 focuses on the improvement of the experimental measurement technique for cryogenic testing. The objectives here are to enhance the measurement accuracy of the results and to generate the capability to apply different important techniques (e.g. transition measurement & deformation measurement). These techniques are finally applied in the ETW at High-Reynolds-Numbers on the HARLS model equipped with the High-Lift-System, designed in WP2. The final assessment of DeSiReH results is done in WP4 by assessing the numerical

Keywords: high-lift,natural laminar flow,cfd,cryogenic wind tunnel testing,piv,tsp,transition,deformation