Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coordination of Oxidative Stress Signalling with Forkhead-Regulated Transcription during the Fission Yeast Cell Cycle (OXICELLCYCLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

Cellular proliferation and environmental factors in general, and cell cycle-regulated transcription and oxidative stress in particular, are of vital importance for aging and accompanying complex diseases. The overall goal of this project is to gain systems-level insight into the intriguing relationship between oxidative stress signalling and cell cycle regulation. Oxidative stress causes widespread cellular damage by increased concentrations of reactive oxygen species. Available data indicate that specific clusters of cell cycle-regulated genes, whose expression depends on members of the conserved forkhead family of transcription factors, are repressed during oxidative stress, and this repression then promotes cell survival. Using fission yeast as a powerful model system, we plan to use a wide range of genome-wide methodologies combined with genetics to elucidate two major questions regarding the connection between oxidative stress and cell cycle control: 1) how stress-activated signalling pathways regulate forkhead-mediated transcription, and 2) how repression of forkhead-mediated transcription in turn leads to oxidative damage protection. This project, which takes advantage of the use of a simple model organism and multiple high-throughput and integrative approaches, will promote a systems-level understanding of the complex interplay between cell cycle control and oxidative stress signalling. To get the most from the proposed research will require interdisciplinary interactions with colleagues both within the host laboratory and with outside experts. The proposed research should result in valuable fundamental information to help tackle aging-related diseases. Importantly, this fellowship would also provide a rich training opportunity, by diversifying research skills and promoting complementary competencies, which would be a crucial step for the motivated and talented candidate towards an independent research career.

Keywords: functional biology,genomics,fission yeast,oxidative stress,cell cycle,systems biology,gene regulation,genetics,proteomics,transcription factor,stress-activated protein kinase signalling
Asymmetric Fluorocyclisations (FLUCYC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

Fluorinated oxygen- or nitrogen-containing heterocycles (lactones, lactams, pyrrolidines and tetrahydrofurans) are important compounds with application in the pharmaceutical and agrochemical industry or as performance compounds in material science. Enantioenriched F-heterocycles with the fluorine substituent on a stereogenic centre are of particular interest but are not easy to access using known protocols. The aim of this proposal is to develop an asymmetric route (including a catalytic variant) to fluorinated heterocycles from prochiral starting materials relying on a fluorocyclisation as the key step. The project builds on literature and data from our laboratory showing that activated and allylsilanes are amenable to fluorocyclisation. Two approaches will be considered to access enantioenriched fluorocyclised heterocycles, based on the use of both novel chiral N-F reagents and well-documented fluorinated cinchona alkaloid derivatives.

Keywords: organic chemistry
SAW-driven single-electron quantum devices with optical readout of the spin (SAWQUBIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

The proposal is aimed at the experimental development of a novel solid-state quantum computation scheme and its interface to quantum optics. The computation scheme, put forward at the University of Cambridge, uses the spin of an electron trapped in the dynamic potential associated with a surface acoustic wave (SAW) as a “flying” qubit. The capture of single electrons in moving quantum dots occurs when the SAW passes along a depleted 1D channel. Channels in parallel provide the set of qubits, forming the core of a SAW-based quantum processor. The objective of this proposal is the development of such SAW-driven single-electron quantum devices and the optical readout of the spin of the electron to extend the capabilities of the quantum processor into the optical domain for quantum communication. A lateral n-p junction will be introduced into a GaAs heterostructure, where each electron recombines, leading to single-photon emission. The measurement of the polarization of the emitted photon will determine the spin of the electron, since the conservation of the angular momentum dictates that the photon will have left or right circular polarization depending on the sign of the component of the electron’s spin in the direction of propagation of the photon. Therefore, the flying-qubit processing scheme may permit the distribution of quantum information quickly over large distances across the quantum circuit, to interface with quantum memory registers at fixed localizations or static qubits, and to transfer a qubit from an electron in a quantum dot to a polarized photon. In addition, the fact that the flux directly measures the average spin alleviates the need for single-shot spin or photon measurements and greatly improves the signal-noise ratio. The cutting-edge research of this proposal will permit the fellow to acquire a strong hands-on experience on the most advanced techniques of nanoelectronics, which will have an enormous impact on his career development.

Keywords: electron-based nano-devices,nanoelectronics,quantum computation,electroacoustics,physics of semiconductors,applied optics
NORFACE Transnational Programme on Migration in Europe (NORFACE PLUS)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Horizontal actions
Action type: Coordination and support actions
Partnership: NORFACE PLUS (ERA-NET)
Countries involved: Finland,Germany,Austria,Iceland,Ireland,Netherlands,Norway,Portugal,Sweden,Denmark,Slovenia,Estonia,United Kingdom
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2009-02-01
End date: 2014-06-30
Duration (months): 65.0
Total project cost (EUR): 28899100.0
EU funding (EUR): 5989100.0
Participants: 14
Project status: CLOSED

During recent years persistent rates of international migration have generated a very high level social, economic and policy concern in Europe. Migration has become a multi-faceted phenomenon, transcending traditional explanations. There is much still to be understood about the causes, actualities and effects of these movements of people. The NORFACE transnational programme “Migration in Europe: Social, Economic, Cultural and Policy Dynamics” has been developed to explain the new challenges Europe faces with migration. It will contribute strongly to our theoretical understanding and knowledge and raise the level of comparative, multi-disciplinary and multi-level research on migration in Europe. The research will provide results with valuable knowledge to be used by policy makers at a national, European and international level. The implementation of the NORFACE research programme will contribute to the building of the European Research Area by strengthening European capacity for multilateral and transnational research. It will also provide an example of significant sharing of research funding between national research agencies in Europe. It will demonstrate that a major transnational programme can be created using a real “common pot” funding. The scientific co-ordinator, Programme Director, will ensure that the individual projects work together so that all the Programme&apos;s resources address the challenge of migration. The Programme will give new visibility to European research, and connect to researchers and policy makers both within and outside Europe. The Programme will stimulate the building of new international connections and networks, and provide new opportunities for the fruitful exchange of knowledge. In order to make major advances in our theoretical understanding and knowledge by bringing together a significant corpus of high quality international teams, the programme will need a budget of the order of €30 million to meet its ambitious objectives.

Keywords: migration,social sciences,joint call,real common pot,user engagement,dissemination
In vitro replication of Pepino mosaic virusand characterization of replication essential host (tomato) factors (PEP-REP-2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 204983.53
EU funding (EUR): 204983.53
Participants: 1
Project status: CLOSED

Replication of positive-strand RNA viruses is a complicated process that involves the virus genome, virus proteins and host factors. In this system, an active replication complex is formed and the central role is played by the viral RNA dependent RNA polymerase. Pepino mosaic virus (PepMV) is a mechanically-transmitted plant virus member of the genus Potexvirus, currently under quarantine in Europe and with great potential of causing serious economical losses to tomato industry. This work extends a recently established bilateral (Greece-Spain) and takes advantage of great expertise of an incoming scientist from Egypt to: 1) purify PepMV membrane-bound replication complexes from infected tomato plants and try to convert them into a soluble, template dependent system for the analysis of viral RNA synthesis, and 2) identify tomato proteins that specifically bind PepMV-encoded proteins and PepMV RNAs (5&apos;- and 3&apos;-untranslated regions). We attempt to establish a model on PepMV to generate valuable data on virus replication with an emphasis on host protein factors. The analysis of viral replication complex components and the identification of the host factors and their role in viral replication constitute two key issues in virology and understanding the mechanisms of viral replication is essential for devising strategies to combat virus-induced diseases. We also intend to extend a research link between three Mediterranean laboratories (Greece, Spain and Egypt) with the view of growing broader and multidisciplinary in the future (e.g. private sector, governmental services, research groups, human capital) given the expansion of the virus and a recent agreement for the establishment of a Euro-Mediterranean Free Trade Area by the year 2010. The proposal capitalizes on the quality of the researcher, the importance of the system chosen in the field of virology and the return potential for the incoming scientist, the host Institute and the expansion of the cooperation.

Keywords: plant virology,potexviruses,virus replication
Carbohydrate utilization by the working muscle of rainbow trout (GLUCOSE USE IN FISH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 219298.04
EU funding (EUR): 219298.04
Participants: 1
Project status: CLOSED

Carbohydrate-rich diets are frequently used in the commercial farming of fish. However, fish do not appear to have an elevated capacity to clear a high load of glucose from their circulation. Special attention has been directed towards the study of the physiological responses to such carbohydrate-rich feeding. Skeletal muscles play a key role in glucose homeostasis in mammals, and exercise has a noticeable effect in lowering plasma glucose. This effect is caused by an up-regulation of glucose transport mediated by GLUT4 in skeletal muscles in response to exercise. However, the exact mediating mechanism in the modulation of glucose transport in skeletal muscle has not been entirely characterized in vertebrates. Moreover, fish are an excellent model for the research of mechanisms involved in changes of the GLUT glucose transporters produced by exercise because they have anatomically separated red and white muscle masses, which allow the measurement of fibre-type-specific responses. I hypothesize that sustained exercise can be used to enhance carbohydrate expenditure in fish, increasing their natural capacity to clear and utilize plasma glucose by the contracting muscle. I will investigate this possibility, placing a special emphasis on the study of the cellular and molecular mechanisms regulating the GLUT-1 and -4 glucose transporters in white and red muscles. Changes in patterns for gene expression using a microarray platform and key biochemical parameters will also be measured in red and white muscles of rainbow trout after four weeks of sustained swimming. I expect that the results obtained from this research will help us to understand how glucose is regulated in fish. This knowledge could be transferred to European companies, leading to more efficient and environmentally conscious feeding practices in the rapidly growing and economic important aquaculture sector.

Keywords: natural sciences,metabolic regulation,physiology,fish,swimming,exercise,insulin,glut4,ampk,muscle
Building a concept of strategic knowledge management in small and medium-sized enterprises based on innovation transfer (SKNOWINNOV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-11-01
End date: 2012-02-29
Duration (months): 28.0
Total project cost (EUR): 153201.65
EU funding (EUR): 153201.65
Participants: 1
Project status: CLOSED

SKnowInnov - creating the new method of strategic knowledge management in small and medium-sized enterprises based on innovation transfer. Decisions by SMEs as regards knowledge development are always made at a strategic level. It seems justified to combine two management fields into one scientific issue. Solving it requires defining objetives and research methodology. General objective: building a concept of strategic knowledge management in SMEs. Goals: •Building a method for planning and assessing investment in knowledge among employees •Developing a model for transfering innovation to companies •Creating a system facilitating decision making at a strategic level in terms of profitability of investment in staff knowledge. It’s necessary to develop a system of strategic knowledge management in SMEs. The project will be implemented according to individual methodology. The stages of methodology are based on goals of project. Stage 2. Literature studies concerning the concept of strategic knowledge management in companies Stage 2: Developing a method for planning and assessing investment in knowledge acquired by employees in companies Stage 3: Developing a system supporting decision making at the strategic level in terms of return on investment in knowledge Stage 4: Building an IT tool supporting decision making at the strategic level as regards profitability of investment in employees’ qualifications and skills Building a modern concept of strategic knowledge management based on experience collected in the Vienna University of Technology will enable to fill gaps on the market as regards strategic management in the form of an IT tool supporting forecasting strategic decisions in a company. The project will promote behaviour culture in scientific units and companies in the field of employee training organisation and running.

Keywords: economics,knowledge-based enterprises
Supporting a person in what (s)he is? An empirical assessment of Honneth's theory of recognition in the light of the encounter with intellectual disability (Down's syndrome and fragile X syndrome) (TESTING RECOGNITION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-01-31
Duration (months): 20.0
Total project cost (EUR): 127359.96
EU funding (EUR): 127359.96
Participants: 1
Project status: CLOSED

The research consists in an empirical test of key statements related to the theory of recognition (Anerkennung) of Axel Honneth. Recognition (Anerkennung) being the fact of &quot;supporting a person in what she or he is&quot;. I consider testing Honneth&apos;s theory along three questions: (1) What contributes to the process of recognition (Anerkennung)? (2) What are the consequences of recognition (Anerkennung)? (3) What is recognition (Anerkennung) applied to? Each of these questions relates to a set of hypotheses, that either suggest a view that is different from what Honneth&apos;s theory describes or relate more tightly to everyday social context The theoretical framework of the proposed research is French pragmatic sociology, that provides concepts for analysing ordinary judgements. The inquiry focuses on the case of persons with intellectual disabilities, because industrial societies, by demanding individual autonomy and economic competitivity, remain extremely excluding for them, and the encounter between a person with such a disability and an &quot;ordinary&quot; person displays major individual differences. I plan a qualitative inquiry based on in-depth semi-structured interviews, recorded and systematically fully transcribed. All of the 9 hypotheses to be tested can be addressed through interviews with parents and with care or education professionals. In order to identify the role played by the legal and institutional environment as well as by the cultural representations, the inquiry includes three countries: France, Belgium and Germany. This research shall contribute to an empirically grounded theory of justice and ethics, in line both with the ambition of Prof. Axel Honneth to carry on the tasks of the Critical Theory and improve our understanding of justice and conflicts in contemporary societies on the one hand, and with the project of Prof. Hille Haker to create a critical ethics of responsibility, whose cornerstone would be the concept of recognition, on the other hand.

Keywords: moral sociology,social philosophy,theory of recognition,biopolitics,disability
Role of the marine carbon cycle in the climate system (PALEOCARB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-07-01
End date: 2011-12-31
Duration (months): 30.0
Total project cost (EUR): 270169.92
EU funding (EUR): 270169.92
Participants: 1
Project status: CLOSED

The general topic of the proposal is the study of the marine carbon cycle and its role in the climate system by driving atmospheric CO2. The investigation of this interaction is vital to understanding the key feedbacks operating in the present-day Earth system. The specific research objectives are to determine at a global scale during key climatic intervals i) the composition and main sources of organic carbon in marine sediments; ii) the relative fluxes of organic carbon from various sources to sediments through time and space; and iii) to relate the relative roles of certain marine carbon cycle processes to changes in atmospheric CO2 concentrations. The approach proposed is to undertake a paleoclimatic study combining geochemical measurements in marine sediments with mathematical simulation experiments, using a 3D climate model with a coupled carbon cycle module. The goal of the project is to obtain quantitative information on marine carbon cycle processes using an interdisciplinary approach. The main reconstruction tools are biomarker proxies, as they provide direct information on the carbon cycle, being carbon based molecules. Three time periods of interest have been selected for the study to represent i) conditions equivalent to present (Holocene); ii) a different response of the climate system to practically the same external forcing (Pliocene); and iii) extreme climatic conditions (LGM). The biomarker data will be contrasted against the carbon model results to seek its validation, and obtain new observational bounds to determine the sensitivity of the Earth’s climate to CO2, with the perspective of improving the Earth system model when used in the assessment of future climate changes. Training will be directed towards acquiring new skills in isotopic techniques to analyze organic matter in marine sediments, and the use of biogeochemical models. Additional skills will be obtained on management, career development, innovation, planning, and change management.

Keywords: climate change,paleoclimate,biogeochemistry,marine carbon cycle,chemical oceanography,biomarkers,marine organic matter,climate and ecosystem modelling,productivity,diagenesis,stable isotopes