Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomic Signatures of Selection In Structured Populations: Detecting Temporal Shifts and Local Adaptation (GENESIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 2
Project status: SIGNED

Demographic and selective processes jointly influence the distribution of species in space and time. However, their interaction remains poorly studied despite its potential to formulate evolutionary and conservation hypotheses. GENESIS aims to characterize how temporal changes in different modes of linked selection – such as positive, negative, divergent, and adaptive introgression – impact genetic diversity in spatially structured populations. To that end, the action will be organized around four key objectives. I will first develop theoretical models (1) and statistical software (2) to detect genomic signatures of selection and their temporal variation. These tools will then be applied to Iberian chubs that display temperature-driven local adaptation and a mito-nuclear discordance (3), and to hybridizing North American pest sawflies to examine how selection shifted over time due to host-jumping (4). By integrating mathematics, bioinformatics, population genetics, evolutionary theory and experimental evolution, this multidisciplinary action aims to fill critical gaps in our understanding of the demography-selection interplay in spatially structured populations. GENESIS will be carried out with leading experts from the University of Lisbon and the University of Kentucky, enabling me to cultivate my network of collaborators. This action will provide me a unique opportunity to further my training in evolutionary biology. I will notably acquire novel skills, expanding my expertise in field and experimental work, and in bioinformatic method development, crucial for my development as an independent researcher. GENESIS will make a bridge between empirical and theoretical evolutionary biology to tackle fundamental questions in adaptation and speciation, with direct implications to ecology and conservation fields, and transferable to address agriculture and global change challenges.

Keywords: population genetics,adaptation,historical demography,coalescence theory,freshwater fishes,pine tree sawflies,hybridization
Labour and Ecology in an International Perspective: Porto Marghera in the Phosphates Archipelago (LabEcoInt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 320924.16
EU funding (EUR): 320924.16
Participants: 2
Project status: SIGNED

This research, hosted by Ca’ Foscari University of Venice in partnership with the Geneva Graduate Institute, investigates the making and unmaking of Europe’s historical industrial areas uncovering the intersections between labour and ecological transformations from an international perspective. It does so by deploying theories of extractivism to the case study of the major industrial cluster of Porto Marghera (Venice, Italy), using the production of phosphate-based fertilisers as an entry point. Porto Marghera’s “super-phosphate” plants were established in the 1920s, in the context of rising fascism. They integrated Porto Marghera with the “green factories” of expanding modern agriculture – downstream –, and with the “Phosphate Archipelago”, a network of extractive and industrial spaces on the two shores of the Mediterranean – upstream. Phosphates thus invisibly and contradictorily connected Porto Marghera’s labour mobilisations with North Africa’s anticolonial struggles. This link was also ecological, as shown by the noxious health and environmental effects of phosphates. The closure of Porto Marghera’s fertiliser plants in the 1990s was in fact accelerated by environmental campaigns against the dumping of phosphate waste into the Adriatic Sea. Meanwhile, restructuring in the extractive areas of Morocco and Tunisia (Khouribga and Gafsa respectively) turned them into important points of departure for working-class migration to Italy. While deindustrial studies focus on the history of industrial areas from a local or national perspective, less attention has been paid to the insertion of such industries in global hierarchies of labour and environmental degradation. By analysing Porto Marghera’s place in the Phosphate Archipelago, this research generates insights for today’s ecological transitions in mining, industry, and agriculture, at a time when fertilisers are once again in the spotlight due to concerns over sustainability and instability in food supply chains.

Keywords: deindustrialisation,extractivism,environmental justice,decolonial studies,environmental labour studies
Discovery, total chemical synthesis, and validation of “mirror-image” D-Nanobodies (MirrorBody)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The central role of molecularly-targeted therapeutics and imaging probes in translational research entails the development of an ever-growing arsenal of “chemical biologics” endowed with optimal in vivo properties. In this regard, mAbs and their derivatives (e.g. ADCs) still suffer from unsettled drawbacks involving difficulties in production and characterization, leading to heterogeneous conjugates in terms of size, potency and toxicity. Chemical modifications on mAbs are highly unreliable due to their complex structure: a central problem in this discipline, where heterogeneous drug-to-antibody ratio (DAR) and conjugation site represent significative limitations. Immunogenicity is a major drawback which affects humanized, as well as fully-human mAbs, and is exacerbated by long half-lives. Cases of unwanted activation of the immune system reportedly degenerated to life-threatening conditions such as acute anaphylaxis, serum sickness and cytokine release syndrome. Their bulky size (≈150 kDa) hinders their extravasation, impairing their efficiency to enter tumors. Nanobodies (Nbs) are the smallest naturally-derived antibody fragments (≈13-14 kDa) that retain antigen-binding affinities in the same range of mAbs (nM to pM affinity range) while having extremely reduced half-lives ( ≈ 15 min.) when not bound to their target, thanks to a fast renal excretion. MirrorBody intends to push the boundaries of targeted “chemical biologics” via an interdisciplinary approach that exploits both immunology and synthetic chemistry techniques for the generation of synthetic D-nanobodies that bind natural L-targets with high affinity. Such unprecedented synthetic D-Nbs will be endowed with improved biocompatibility, and will enable “plug-and-play” approaches for the controlled conjugation of diverse moieties.

Keywords: chemical protein synthesis,d protein,d peptide,single domain antibody,nanobody,molecular targeting,chemical ligation,glycopeptide,racemic crystallography,chirality
Towards a Diachronic Music Theory (DIACHRONY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

This proposal argues for a quantum shift in the way we theorize about music. In the past three decades, music theory has been dominated by synchronic theories based upon typologies. The value of these theories notwithstanding, there are three significant “blindspots” that arise from a purely synchronic perspective. First, synchronic approaches are incapable of explaining trends – they at best capture “snapshots” along a timeline, but cannot explain processes: how one snapshot progressed to another. Second, music written between two snapshots is evaluated in synchronic approaches either according to a defunct model, or according to one that had not yet come into existence, as often occurs with the music of the generation between Bach and Mozart. Third, such snapshots mask trends during their period of interest behind a false façade of stability. I propose to address this problem through a diachronic methodology, designed to focus not on definitions and synchronic typologies, but rather on processes of change over time. To this end I will carry out a corpus study of unprecedented scope, covering 1700 works between 1680-1819. In two overlapping subprojects based upon the same corpus, I will examine trends in four fields: large-scale form; phrase structure; cadences (musical units signifying closure); and schemata (stock musical phrases). Tracing the diachronic process of change across the decades of the corpus, I will reveal the forces that propelled music from one style to another, and through this, the tensions with which composers were faced and to which they responded. Furthermore, my novel diachronic approach will enable a more flexible mode of accounting for the fuzzy limits of theoretical definitions and histories. Lastly, with its original conceptual premises and its corpus-based methodology, this project will serve as a model for a new approach to music theory, encouraging the embrace of a diachronic perspective in other fields of music theory too.

Keywords: eighteenth century music corpus studies music theory cadences schema theory sonata form formenlehre
Superlattices of Perovskite Quantum-Dots for the Digital-age (SUPER-QD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 282168.0
EU funding (EUR): 282168.0
Participants: 2
Project status: SIGNED

Photonic integrated chips are key for the EU’s pursuit of faster and more efficient computers, aiming to support the Digital Revolution while reducing the costs of ICT. However, progress in photonic devices is held back by challenges in the miniaturization of on-chip light sources. SUPER-QD aims to tackle these challenges by using Superlattices of lead halide perovskite Quantum Dots as micron-size on-chip emitters. Thanks to their color-tunable and bright fluorescence, these nanocrystals solids are efficient micron-size light down-converters, that will allow implementing more color channels per device without compromising miniaturization. Moreover, the coupling between quantum dots results in superior exciton mobility and emission from collective quantum states (superfluorescence), which are promising for future applications in transceivers and quantum computers. SUPER-QD comprises four tasks: 1) Quantum Dots prepared via wet chemistry are assembled into Superlattices with tunable structure. 2) Innovative diffraction techniques are employed to characterize Superlattices, with a focus on structural and energetic disorder. 3) Collective optical properties are studied via space- and time-resolved spectroscopies to discover new structure-coupling relations, with the goal of tuning the Superlattices quantum light emission through their structure. 4) Finally, Superlattices with optimized properties will be installed in Integrated Photonic Chips, to demonstrate on-chip down-converting optical amplification upon photoexcitation from an integrated blue laser. These proof-of-concept devices will create new connections between colloidal nanomaterials and photonic integrated chips, leading to groundbreaking advancements in both fields. SUPER-QD will be hosted by Lund University and the Massachusetts Institute of Technology, leveraging the Fellows’ and Host Institutions’ expertise to ensure a mutual benefit from the Action and the success of the ambitious goals of the project.

Keywords: nanocrystal,quantum dot,superlattice,self assembly,lead halide,perovskite,exciton diffusion,superfluorescence,structure property relation,photonic integrated chip,x ray diffraction,disorder
Innovating New Space Frontiers: Harmonised Federated and Fractionated Systems Unlocking Fresh Perspectives for Satellite Services (HARMONY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Spain,Lithuania,Germany,Italy,United Kingdom
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2683460.54
EU funding (EUR): 2092946.2
Participants: 10
Project status: SIGNED

Major developments in small satellite technologies coupled with the rapid commercialisation of New Space are disrupting the space landscape. A driving role rests with the telecommunication vertical, where market demands for global connectivity led to the emergence of LEO and MEO mega-constellation and are accelerating efforts for the integration of non-terrestrial with terrestrial networks. Core to this vision is an architectural paradigm shift from large monolithic satellites to an orchestrated network of multi-orbit spaceborne nodes of various sizes and capabilities. On the other hand, space missions traditionally dominated by governmental initiatives - such as Navigation (GNSS) and Earth observation (EO) - are slower in adopting the New Space spirit towards coordination and synergetic exploitation of emerging and established satellite systems. Yet these systems have had transformative impact on our daily lives along a plethora of applications and verticals. Anticipating the next New Space frontiers in commercially driven missions within these domains, a central view of HARMONY is that step change potential will be released by adopting distributed satellite architectures across a range of existing and new applications where the space environment provides unique benefits. Placing innovative space services at its core, HARMONY will adopt a cross-disciplinary & vertically integrated approach in the study of federated and fractionated satellite system architectures and the development of core underpinning technologies in a doctoral network that will nurture future European New Space leaders.

Keywords: satellite systems
Quartz Enrichment Enabling Near-Zero Silicon Production (QUEEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Norway,Italy,United Kingdom,Poland,Slovenia,Slovakia,Ukraine
Call: Technologies for processing and refining of critical raw materials (IA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 8969480.0
EU funding (EUR): 7291537.27
Participants: 15
Project status: SIGNED

The QUEEN project, with its strong consortium of participants from eight countries, addresses a significant challenge - EU's heavy reliance on external sources for critical raw materials, especially metallurgical silicon (MG-Si). Currently, over 80% of MG-Si, vital for high-tech applications and EU's sustainability ambitions, is imported mainly from China. QUEEN aims to exploit an underutilized resource; quartz sand from European quarries, to domestically produce MG-Si in a sustainable and efficient way. The unique approach combines raw material extraction and refinement with an environmental focus, leveraging waste materials in the process. This strategy is projected to bolster EU's MG-Si production capacity, foster sector-specific innovation, and advance eco-friendly practices. The QUEEN project's overall objective is to create an environmentally friendly process for producing metallurgical silicon (MG-Si) from quarry sands, with near-zero CO2 emissions. This transformational approach could turn any EU quartz quarry into a potential MG-Si reservoir. Moreover, the technologies developed could be adapted to other materials. The technical objective is to devise a new mineralogical separation process based on flotation for quarry sands extraction. This objective aims to pioneer a more effective and greener alternative process for refining high-purity quartz and Potassium Feldspars. Comprising R&D and industry stakeholders from mineral separation and MG-Si refinement fields, the project plans pilot tests at TRL 7. QUEEN aims to cover 56% of MG-Si EU demand by 2032 by recovering more than 300Mt MG-Si from sands, alongside saving about 232,000 Mt CO2 by substituting coal with cleaner materials. Like this, QUEEN aims to support the EU strategic autonomy and sustainability, mirroring its green ambitions.

Keywords: froth flotation,waste management,circular economy,silicon,quarry sands,quartz
Social Sciences Participatory Research-Action for Preparedness in Risk Management for Disasters and Health Emergencies in Europe’s Cities (Sonar-Cities)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: France,Sweden,Belgium,Netherlands,Austria,Slovenia,Italy,Croatia
Call: Improving social and societal preparedness for disaster response and health emergencies (HORIZON-CL3-2023-DRS-01, 2023)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 4115620.0
EU funding (EUR): 3999995.0
Participants: 13
Project status: SIGNED

Disasters, including health emergencies, pose enormous strains on response capacities of cities, countries, and the European Union, compounding existing climatic, political, economic, and social challenges. The risks and consequences of these emergencies reduce the health and well-being of Europe’s inhabitants. But their burdens are not evenly shouldered across all populations. Cities face huge challenges in preparing for and responding to disasters: urban publics not only suffer higher morbidity and mortality during such emergencies but resulting instability and response measures can exacerbate social and health inequalities. Vulnerable urban inhabitants are at risk during such crises for exclusion and heightened health consequences. With lower access to health information, resources, care and support, they tend to experience higher mortality and morbidity and longer-term reductions in health. The goal of Sonar-Cities is to render Europe’s cities more resilient in health emergencies and disasters through the co-creation and implementation of a community-based, adapted toolset for people facing vulnerabilities, first responders, and decisionmakers. By strengthening inclusivity in risk management, we will enhance preparedness and reduce risks posed by these emergencies. We will analyze One Health factors and consequences of past emergencies in 6 European cities, notably from the perspectives of people experiencing vulnerabilities. We use these analyses to co-create with publics at risk, first responders, and authorities a citizen-centered toolset, which will generate inclusive preparedness, improve health literacy and crisis communication, strengthen capacity and decision-making, and reduce risks of disasters/health emergencies in European cities. We will disseminate the toolset through our interactive Knowledge Platform and offer a Social Sciences Emergency Support network for authorities seeking social sciences assistance during health emergencies and disasters.

Keywords: vulnerability disaster resilience and crisis management crisis communication health literacy social inclusivity co creation knowledge platform information technology social sciences
From streetlight to starlight: How light pollution disrupts insect orientation and alters habitat connectivity (LIGHTSTAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499511.25
EU funding (EUR): 1499511.0
Participants: 1
Project status: SIGNED

The widespread use of artificial lighting has drastically changed night skies across the globe, creating a specific threat to nocturnal species: light pollution. Recently, light pollution has been identified as one driver of insect decline. Among nocturnal insects, moths are particularly important as they serve as both key pollinators and food source, providing essential ecosystem functions. To mitigate the effects of light pollution, a comprehensive understanding of moth orientation is essential, including their response to natural and artificial light as well as their interplay. To date the available data is extremely limited, primarily due to the challenging conditions of night-time research and the lack of methods for collecting behavioural data in the field. LIGHTSTAR will set a paradigm-shift beyond classical field and laboratory experiments by combining large-scale field experiments across a light pollution gradient with targeted manipulations of streetlights, moonlight, and polarized light. This approach will allow an in-depth investigation on the orientation performance of moths in dependence on the light environment. We will develop a drone-based 3D tracking system to obtain behavioural data of unprecedented spatial and temporal resolution. Incorporating these novel 3D data into our advanced simulation tools will fundamentally broaden our understanding of habitat fragmentation caused by streetlights and will allow a new dimension of assessing habitat connectivity. The data collected will, for the first time, provide a holistic understanding of the impact of light pollution on the orientation of nocturnal insects. Our discoveries will be highly valuable for developing strategies to mitigate their decline and promote insect-friendly lighting solutions that can reduce the risk of species extinctions and maintain connectivity of habitats. Moreover, our new tracking system will unlock new realms for all research on movement and behavioural ecology of insects.

Keywords: light pollution,insect orientation,habitat connectivity,3d insect tracking,insect decline,streetlights,moths,insect friendly lighting,mating success