Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Training Network for the Immunotherapy of Cancer (IMMUTRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Italy,Germany,Spain,Germany,France,Netherlands,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 3627525.24
EU funding (EUR): 3627525.24
Participants: 10
Project status: CLOSED

In the European Union, cancer is the leading cause of death and the overall cancer incidence is still increasing. As a result of expanding efforts to improve cancer outcome, a main paradigm change is occurring in cancer therapy towards individualized medicine. Antibody-based therapies form an integral and constantly growing part of this approach. Antibody-based therapies will strongly influence the coming decade of cancer care. The importance of immunotherapy has been highlighted by the prestigious Science journal as “breakthrough of the year 2013”, heralding the rising importance of immunotherapy. Accordingly the need for well-trained and skilled researchers in academia and industry is dramatically increasing in this field. IMMUTRAIN is a training network bringing together experts in the fields of monoclonal antibodies, dendritic cells, T-cells and immunomodulatory nucleic acids with a considerable industrial involvement. The network comprises nine academic research groups and five industrial partners in a total of seven European countries. IMMUTRAIN will actively create synergies between those sectors by forming and promoting young researchers to match the challenges of immunotherapies. Particular focus will be placed on combinatorial therapies and on the new emerging field of bispecific antibodies used to target both the tumor and the patient´s immune system. Fifteen Ph. D. students (early stage researchers, ESR) reinforced by the project leaders will investigate innovative therapeutic strategies and provide the rationale for future clinical trials. Throughout their projects, ESR will learn to integrate academic and industrial aspects and will sharpen their experimental and complementary skills in a well-designed and diversified training program.

Keywords: immunotherapy,antibodies,combination therapy
De novo protein discovery as a tool for understanding the folding conundrum (NovoFold)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-03
End date: 2021-06-05
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Order is a prerequisite for activity, which is the essence of the sequence-structure-function paradigm of bio-macromolecules. Proteins are a case in point, displaying intricate architectures and impressive functions. Understanding how the primary sequence of these complex macromolecules relates to their 3D structure and vice versa is of fundamental interest and the basis for broad technological exploitation of proteins. The proposed research aims to investigate the folding space of proteins, gaining new insights that will help in solving the folding conundrum. Specifically, the frequency and sequence patterns of ordered polypeptides and their physical and structural properties will be experimentally analysed. Based on these data sets, exploratory data analysis can be performed, providing unprecedented insights into protein folding. Generation of quantifiable high quality data is thus of utmost importance for this project. One of the main objectives of this proposal is therefore the development of an ultrahigh-throughput experimental platform for discovery of de novo proteins with unparalleled precision, using state-of-the-art molecular biology methods. Based on cutting-edge mRNA display technology, I will isolate folded polypeptides from naïve libraries with up to 1E13 members in the size range of 50-100 amino acids. Modern bioinformatic analysis, modelling and biophysical characterisation will be performed to analyse the folding space of proteins and derive new empirical folding rules. Given the increasing importance of protein engineering in fundamental research and industry, the results of this study will be of interest to a wide range of scientists. The fellowship will provide training in state-of-the-art techniques such as statistical data analysis and structural biology. The results of this research project will form the basis for future efforts to exploit the biotechnological potential of newly discovered proteins.

Keywords: protein folding,in vitro selection,naive libraries,de novo proteins
Cognitive Aging: From Educational Opportunities to Individual Risk Profiles (CRISP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Luxembourg
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-07-31
Duration (months): 67.0
Total project cost (EUR): 1148290.0
EU funding (EUR): 1148290.0
Participants: 1
Project status: SIGNED

Cognitive impairment and dementia have dramatic individual and social consequences, and create high economic costs for societies. In order to delay cognitive aging of future generations as long as possible, we need evidence about which contextual factors are most supportive for individuals to reach highest cognitive levels relative to their potential. At the same time, for current older generations, we need scalable methods to exactly identify individuals at risk of cognitive impairment. The project intends to apply recent methodological and statistical advancements to reach two objectives. Firstly, contextual influences on cognitive aging will be comparatively assessed, with a focus on inequalities related to educational opportunities and gender inequalities. This will be done using longitudinal, population-representative, harmonized cross-national aging surveys, merged with contextual information. Secondly, the project will quantify the ability of singular and clustered individual characteristics, such as indicators of cognitive reserve and behaviour change, to predict cognitive aging and diagnosis of dementia. Project methodology will rely partly on parametric ‘traditional’ multilevel- or fixed-effects modelling, partly on non-parametric statistical learning approaches, to address objectives both hypothesis- and data-driven. Applying statistical learning techniques in the field of cognitive reserve will open new research avenues for efficient handling of large amounts of data, among which most prominently the accurate prediction of health and disease outcomes. Quantifying the role of contextual inequalities related to education and gender will guide policymaking in and beyond the project. Assessing risk profiles of individuals in relation to cognitive aging will support efficient and scalable risk screening of individuals. Identifying the value of behaviour change to delay cognitive impairment will guide treatment plans for individuals affected by dementia.

Keywords: cognitive function,cognitive aging,dementia,inequality of educational opportunities,gender inequalities,older age,life course,cognitive screening,statistical learning,applied predictive model
Duo: A minimally invasive device to treat all patients with tricuspid valve disease (Duo)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Ireland,Israel,Ireland,Belgium
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 4256837.5
EU funding (EUR): 2969786.0
Participants: 4
Project status: SIGNED

Heart failure is the leading cause of death, affecting 15 million patients across Europe and the US. In patients with heart failure, the right heart expands, resulting in the tricuspid valve not closing properly and blood leaking backwards. This is called tricuspid regurgitation. The tricuspid valve has remained largely untreated due to unique functional and anatomical challenges. Currently less than 1% of patients are surgically treated due to the fact that open-heart surgery is still the only treatment option and is very risky. As a result, these patients face worsening quality of life with 60% of patients not surviving past 3 years. The Duo project aims to enable the commercialisation of a minimally invasive device that restores the function of the tricuspid valve in a safe and effective manner for all patients with TR. An innovative adjustable anchor holds the device in position between the tricuspid valve leaflets, anchored against the venous wall, where it does not touch the fragile cardiac tissue. This multi-disciplinary consortium of innovative SME’s is uniquely positioned to accelerate bringing this disruptive technology to market. CroiValve, the consortium coordinator, was founded specifically to develop and commercialise a minimally invasive tricuspid treatment. ICS Medical is an expert in the design, development and manufacturing of complex catheter solutions. Syntactx is a full-service CRO that understands how to deliver efficient and good quality clinical data. 3D LaserTec is an innovation driven centre for laser cut parts. With Fast Track to Innovation funding, the consortium will finalise the development of the Duo-TF device and develop US clinical evidence demonstrating the clinical benefits of Duo to the patient. This will position Duo as the gold standard treatment, thus saving the lives of thousands of patients and reducing this significant healthcare burden. The project will also enable Europe to take the lead in the large tricuspid €2.5Bn/year market.

Keywords: heart valve,structural heart,minimally invasive,heart failure
KEEP-IT-UP: Redefining shelf life monitoring in the global food industry with a new intelligent Time-Temperature Indicator for perishable products (KEEP-IT-UP)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Norway
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Keep-it Technologies AS (Norway) is a fast-growing company backed up by an outstanding team of 23 experts in food retail, brand building and product development. We have developed the Keep-itUp Time-Temperature Indicators, using a patented chemical process to measure the time and the temperature to which a product has been exposed to. These provide continuous and quantitative information (in days left to spoilage) of fresh food and ready-to-eat meals’, according to the temperature they are exposed to over time, thus introducing the concept of planning in consumption for the first time: when a product is kept at proper temperatures, it allows the extension of its shelf life in 5-6 days. Although a first version of Keep-itUp indicators has been already produced in small scale in Norway the feedback confirms that there is a lot of room for improvement. The goal of the Keep-itUp project is to increase accuracy, adapt them to different types of food products and target markets’ needs, to optimize their production line, and to seek further international expansion. The Keep-itUp project responds to two pressing needs: reducing food waste (an EU priority) and the quality assurance of food, as it regulates the spread of foodborne illness. Keep-itUp will contribute to a more suitable food future, by reducing food waste and will help its end-users (consumers) to improve their consumption habits, thus reducing food waste; will help retailers increase their profits by guaranteeing the quality of products sold through different stages of the cold-chain; and allow producers to increase their ROI, reduce food losses and deliver higher quality products. With Keep-itUp we will reach our sales objective of 300M units/year, thus growing our revenues to €12.76 million by 2022, while creating 47 new direct jobs. The project has an estimated ROI of 4.01 per euro invested

Keywords: time temperature indicator,chemical indicator,fresh food,perishable,product,retail,producer,consumer,food waste
Does reducing β-cell glucotoxicity increase the hyperglycaemia-lowering effect of physical exercise in type 2 diabetes? (GLUCOTOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Hyperglycaemia in type 2 diabetes (T2D) doubles mortality and arises due to failure of pancreatic β-cell insulin secretory function to overcome insulin resistance. Exercise reduces hyperglycaemia by improving insulin sensitivity and β-cell function; however, the variability of this beneficial effect is huge and is associated with high blood glucose and poor insulin secretion. Hyperglycaemia increases interleukin-(IL)1β levels causing β-cell death and insulin secretory dysfunction (glucotoxicity), and these phenomena are all elevated in T2D and are also augmented by IL-6, which alone is not toxic to β-cells. Interestingly, blood IL-6 levels are not only increased in T2D but are also increased following exercise due to secretion from muscle. Therefore the huge variability in the adaptation to exercise may be due to muscle IL-6-induced enhancement of IL-1β-induced β-cell dysfunction. Thus, exercise may be detrimental to T2D patients with β-cell glucotoxicity. Our objective is to determine the independent and interactive roles of IL-6 and IL-1β in the adaptations to exercise in T2D. We will achieve this by integrating the human physiology expertise of the Experienced Researcher with the transgenic mouse model expertise of the Supervisor to create a bench-to-bedside approach from which both the host institution and the experienced researcher will gain from in the future. Innovative muscle-specific IL-6 knockout mouse models and clinical anti-IL-1β drug treatment approaches will be used to ultimately increase the knowledge of how IL-6 and IL-1β interact, making it possible to optimise exercise therapy for all T2D patients, including those who would otherwise be classified as a “non-responder”.

Keywords: cell function,type 2 diabetes,glucose metabolism,exercise
Water scenarios For Copernicus Exploitation (Water-ForCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Germany,Spain,Italy,Spain,Belgium,Belgium,Belgium,Greece,Romania,Slovenia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Copernicus evolution: Mission exploitation concept for WATER (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2999575.0
EU funding (EUR): 2999575.0
Participants: 21
Project status: SIGNED

Unprecedented availability of free-to-access satellite data from the Copernicus programme has started to transform approaches to the assessment, monitoring and sustainable management of our aquatic environments. However, whilst the Copernicus Land Monitoring Service delivers the first generation of inland water quantity and quality products, other directly related products are fragmented across other services (e.g. EMS, C3S, CMEMS, CAMS, CIS). R&D capabilities have rapidly expanded through H2020 and ESA projects working on inland water challenges, but lack of coordination has led to a fragmented approach to evolving the service components and some confusion in a potentially broad user community. Thus, this expansion has not been matched by uptake of these products by decision makers, monitoring agencies, industry or the wider public. Water-ForCE will co-create a Roadmap for the development of the next phase of Copernicus Inland Water Services with the space sector, research community, policy, industry and third sector. The Roadmap will be benchmarked against community requirements, recommending services that should be delivered centrally by Copernicus and innovation opportunities that are better suited for business and research development. The Roadmap will also provide the strategy to ensure effective uptake of water-related services by end users, further support the implementation of relevant directives and policies and evidence policy development. This cross-disciplinary approach will align in situ and remote observation as this is essential to furthering the exploitation of operational observation platforms. A strategy to integrate in situ networks will be defined, integrating approaches to product validation and filling observation gaps and thus strengthen user confidence. Technical requirements for the future Copernicus sensors will also be specified for optimal inland water monitoring needs and future service development.

Keywords: remote sensing,inland waters,in situ networks,copernicus services,water cycle
Lifecare’s Sencell sensor is an implantable micro-sensor for subcutaneous location, long time, continuous, wireless, real time monitoring of interstitial glucose for diabetes management. (Sencell16)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Norway
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The SENCELL Glucose Monitoring System includes an osmotic pressure sensor, transmitter and mobile medical application. The miniaturized sensor is designed to be implanted into the subcutaneous space of arm wrist or other suitable body sites and requires no battery or wires for the sensor operation and for communication with the transmitter. After insertion, the sensor is designed to function noninvasively, automatically, and continuously for a long term duration that is comparable or longer than existing product alternatives. The miniaturized SENCELL is designed to continuously measure glucose in the interstitial fluid for a long term duration that is comparable or longer than existing product alternatives. Unlike currently used glucose sensors, the Sencell is intended to be implanted subcutaneously on the arm wrist or other subcutaneous places in the body with no sensor part protruding from the skin. Encased in a biocompatible material, the device utilizes a unique osmotic pressure assessment technology, which translates the signal of a physical miniaturized osmotic pressure cell into an accurate glucose reading that can be used for determination of insulin doses and to generate warning signals in case of hypoglycemia or hyperglycemia development. The inner core of the device is the unique and proprietary osmotic patented pressure cell, which is covered on one side by a semi-permeable membrane. The membrane is enclosed inside the top of a cavity where the pressure transducer is also located. The cavity contains Concanavalin A and Dextran. The use of ConA/Dextran as enzymatic component significantly improves the sensitivity to changes in the blood sugar level while reducing the influence from other substances in the blood. In the final product, the measurement is then relayed to the transmitter. The entire measurement is designed to be done autonomously and independently without any prompting by the user. However, the user can induce a measurement at any time

Keywords: micro sensor,implantable,longterm measurement,read out units,continuous monitoring of glucose
Gaming Horizons (Gaming Horizons)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,United Kingdom
Call: Enabling responsible ICT-related research and innovation (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2018-01-31
Duration (months): 14.0
Total project cost (EUR): 483427.5
EU funding (EUR): 483427.5
Participants: 3
Project status: CLOSED

GAMING HORIZONS s is a multidisciplinary project that aims to expand the research and innovation agenda on serious gaming and gamification. The project is particularly interested in the use of games for learning and cultural development. Gamification - and gaming more broadly – are very important from a socio-economic point of view, but over the past few years they have been at the centre of critical and challenging debates, which highlighted issues such as gender and minority representation, and exploitative game mechanics. Our project’s key contention is that it is important for the European ICT community to engage with design trends and social themes that have affected profoundly the mainstream and ‘independent’ game development cultures over the past few years, especially because the boundaries between leisure and serious games are increasingly blurred. GAMING HORIZONS is a direct response to the official recognition by the H2020 programme of work that multidisciplinary research can help to advance the integration between Responsible Research and Innovation (RRI) and the Social Sciences and the Humanities (SSH). The project’s objective is to enable a higher uptake of socially responsible ICT-related research in relation to gaming. This objective will be achieved through a research-based exchange between communities of developers, policy makers, users and researchers. The methodology will involve innovative data collection activities and consultations with a range of stakeholders over a period of 14 months. We will interrogate the official ‘H2020 discourse’ on gamification – with a particular focus on ‘gamified learning’ - whilst engaging with experts, developers and critical commentators through interviews, events, workshops and systematic dialogue with an Advisory Board. Ultimately, GAMING HORIZONS will help identify future directions at the intersection of ethics, social research, and both the digital entertainment and serious games industries.

Keywords: gamification,game based learning,sister project,multidisciplinary research,social sciences,humanities