Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Drilling in supercritical geothermal condition (DESCRAMBLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Norway
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 15687222.5
EU funding (EUR): 6753635.0
Participants: 8
Project status: CLOSED

The aim of the “Drilling in dEep, Super-CRitical AMBients of continentaL Europe: DESCRAMBLE" project is to develop novel drilling technologies for a proof-of-concept test of reaching deep geothermal resources and to contribute to a low-carbon European society. To achieve this target the first drilling in the world in an intra-continental site at a middle-crustal level will be performed. The test site is an existing dry well in Larderello, Italy, already drilled to a depth of 2.2 km and temperature of 350 °C, which will be further drilled to 3-3.5 km to reach super-critical conditions unexpectedly experienced, and not controlled, in a nearby well in 1979. The project will be organized into two main phases: (1) Drilling in super-critical conditions, including drilling components, well materials, design and control; (2) Geo-Scientific activities for predicting and controlling critical conditions, which considers petrological, physical and chemical characterization, simulation and monitoring, including high temperature and pressure tools. Main expected outcomes: • Improved drilling concepts in deep crustal conditions • New drilling materials, equipment and tools • Physical and chemical characterization of deep crustal fluids and rocks The site is perfect for such an experiment, as it is representative of most deep crustal levels in Europe, cost effective since drilling to reach the target is reduced to a minimum, practical due to the high probability of encountering super-critical conditions. The productivity and efficiency of the project are guaranteed by the combination of industrial and research participation and by the recognised expertise of the consortium in geothermal R&D as well as oil and gas drilling, bringing together excellence in the respective sectors. DESCRAMBLE will explore the possibility of reaching extremely high specific productivity per well, up to ten times the standard productivity, with a closed loop, zero emission, and reduced land occupation.

Keywords: drilling technologies,supercritical conditions,deep geothermal resources
Exploring and Modifying the Sense of Time in Virtual Environments (VIRTUALTIMES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Finland,France
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 4404698.75
EU funding (EUR): 4404698.75
Participants: 6
Project status: SIGNED

The sense of time co-constitutes our subjective experience and embodied self-consciousness. It refers to the dimensions of passage of time (time passing by) and structure of time (serial order of events). Both can be disturbed under psychopathological conditions and give rise to a variety of psychopathological symptoms. VIRTUALTIMES will for the first time (1) provide a personalized and neuroadaptive virtual reality technol-ogy enabling the systematic variation of time experience (“MetaChron”), based on (2) the rigorous study of the sense of time in different psychopathological conditions including depression, schizophrenia and autism, under special consideration of sex, and (3) neuroscientific measures that describe neural mechanisms which underlie our sense of time and validate both diagnostic differences and technological interventions. For that purpose, virtual reality scenarios and games will be developed from the starting point of the everyday sce-nario “waiting room”. We will systematically enrich the scenery both physically (objects) and socially (inter-action partners). In the realm of time-based interventions this will allow to manipulate passage of time (vary-ing velocity of time flow) and structure of time (varying synchronicity of events). VIRTUALTIMES (1) will provide “MetaChron” as diagnostic tool and innovative mental health technology that works in a highly in-dividualized, easy-access, and easy-to-use application, (2) will foster new technological developments in the field of human-computer-interaction to improve personal wellbeing and intercultural communication in a global world, and (3) will initiate a radical shift both in empirical approaches to and our understanding of the sense of time as basic constituent of human subjectivity. The market value lies in the availability of a professional VR- and game-based tool for prevention and therapy of psychopathological conditions.

Keywords: time experience time psychology,psychopathology human computer interaction hci,artificial intelligence ai,virtual reality vr physiology,neuroscience
Replaying the ‘genome duplication’ tape of life: the importance of polyploidy for adaptation in a changing environment (DOUBLE-TROUBLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Thousands of species are polyploid. However, the long-term establishment of organisms that have undergone ancient whole genome duplications (WGDs) has been exceedingly rare and when we analyse the genomes of plants and animals, we can, at most, find evidence for a very limited number of WGDs that survived on the longer term. The paucity of (established) ancient genome duplications and the existence of so many species that are currently polyploid provides a fascinating paradox. There is growing evidence that the majority of ancient WGDs were established at specific times in evolution, for instance during periods of environmental change and periods of mass-extinction. The reason for this ‘stress’-polyploidy relationship has been the subject of considerable speculation and several hypotheses have been put forward to explain this observation: (a) stressful conditions promote polyploid formation; (b) polyploidisation causes a niche shift allowing polyploids to grow in conditions that are unsuitable for their non-polyploid ancestors; and (c) polyploids have an increased evolvability and consequently adapt faster to a changing environment. Here, we want to unravel the mechanistic underpinnings of why and how polyploids can outcompete non-polyploids. We will address these questions by replaying the ‘genome duplication tape of life’ in two different model systems, namely Chlamydomonas and Spirodela. We will run long-term evolutionary (and resequencing) experiments. We will complement these experiments with in-silico experiments based on so-called digital organisms running on artificial genomes. Complementary modelling approaches will also be employed to study the effects of polyploidy from an eco-evolutionary dynamics perspective. By integrating the results obtained from these in vivo and in silico experiments, we will obtain important novel insights in the adaptive potential of polyploids under stressful conditions or during times of environmental and/or climate change.

Keywords: polyploidy,whole genome duplication,evolutionary experiments,ngs sequencing,artificial evolution
Unravelling perspective-taking: Examining the influence of multiple constraints on perspective selection and multimodal behavior through a dynamical systems' approach (Dynamic Perspectives)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-22
End date: 2019-08-21
Duration (months): 36.0
Total project cost (EUR): 253954.8
EU funding (EUR): 253954.8
Participants: 2
Project status: CLOSED

Speakers routinely adapt their utterances and behaviour to converge on a shared perspective with their conversational partners. However, several aspects of perspective-taking are still underexplored. These include (i) the time course with which the partner’s perspective is considered, (ii) how the partner’s perspective interacts with other environmental and social cues, and (iii) how perspective choices are indexed by speakers’ behaviour. The proposed project addresses these issues by examining micro-behavioural measurements in (a) a set of mouse-tracking studies in which listeners respond to spatial instructions from an assumed partner, (b) a set of interactive studies in which dyads collaborate in a spatial task while multiple channels of their behaviour are sampled, and (c) a model based on the latter experimental data aiming to predict perspective from signatures in the dynamics of dyads’ multimodal behaviour. The empirical findings of the project can shed new theoretical light on the constraints of perspective-taking, but also supply clues for optimizing task and technology design. Dr Alexia Galati will pursue this project with Dr Rick Dale at the Cognitive and Information Sciences unit at the University of California, Merced (UCM), which comprises a critical mass of experts in dynamical systems. The embedded training in dynamical approaches involves novel and transferable technical tools that can be applied to activities ranging from user interface development, data visualization and synchronization, statistical analysis, and modelling. During the return phase, Dr Galati will transfer her new knowledge and skills to her collaborators and mentees at the University of Cyprus (UCY), under the supervision of Dr Marios Avraamides.

Keywords: dynamical systems,audience design,psycholinguistics,spatial cognition,perspective taking
The molecular mechanism of E. coli FimH pathogenicity (FimH-Mech)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Pathogenic bacteria such as E. coli are responsible for a large variety of diseases, including persistent urinary tract and intestinal infections. Their adhesion to the host cell wall is promoted by the binding of FimH located at the tip of the bacterial fimbriae to highly mannosylated cell surface receptors. To resist human defences such as the urinary flow, bacterial adhesion is enhanced under shear force. The shear-force dependence and thus also the pathogenicity of different E. coli strains has been shown to depend on natural sequential variation of the FimH protein. Also probiotic E. coli strains have been shown to attach to host cells, which raises the question as to why these bacteria evoke a beneficial effect upon their host. The FimH-Mech project intends to decipher the molecular mechanism that determines the pathogenicity of different E. coli strains, by investigating the shear-force dependence of FimH and FimH variants and by modelling the complex formation with one of its targets receptors, namely CEACAM6. The results of these investigations will allow me to establish the molecular difference between a pathogenic and probiotic FimH adhesin. I will use a large variety of state-of-the-art computational and theoretical techniques, such as molecular modelling, quantum mechanics, docking and two-state kinetic models. These techniques will be enriched by but also feed into experimental essays to be performed in the host institute. The thus gained understanding of the molecular action of bacterial adhesins will allow for the development of more efficient inhibitors. This constitutes a promising and important milestone in the design of new non-antibiotic drugs against harmful adhesive bacteria.

Keywords: bacterial adhesion,shear force,host pathogen interaction,molecular simulation,glycoproteins
A custom lock chip for compact NMR (LockChip)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Nuclear magnetic resonance is an important chemical analysis method, because of its inherent chemical specificity, its versatility to extract molecular information, and its absolute accuracy. The market has been dominated by large superconducting NMR magnets with price tags of many 100k €. The emergence of less expensive low field compact (tabletop and portable) NMR spectrometers, based on the use of permanent magnets, with price tags around a factor of 10 lower than superconducting magnets, brings a drastically lower cost-of-ownership, and the significantly lower need for external support, maintenance, and lack of liquid Helium, which is opening up new applications and huge new markets for NMR. Compact NMR spectrometers, mainly used for teaching but targeting professional applications (e.g. real time process monitoring in chemical factories), have very cramped magnet bores (15 mm cube) mainly needed for the generation and detection of analyte signal. The magnetic field strength of their permanent magnets is strongly temperature dependent, so that the proportional NMR frequency drifts during measurements that are taken over extended time periods, which can lead to erroneous resonance results and is a major challenge, especially for forensic applications, or applications in factories. The remedy is to detect the temperature-dependent frequency shifts of a special lock substance, which is typically mixed into the sample, but cannot be done in the case of factory automation applications. This represents a big barrier for the introduction of compact NMR into many professional applications. Our miniaturized NMR detector, entitled LockChip, provides an ideal solution for all aspects. Its extremely compact size, easily fits side-by-side with the vendor NMR detector, with only two leads of wire needed to connect it to the lock channel circuitry. Our chip can therefore solve this issue, and help to open up a vast market.

Keywords: low field portable nmr,independent lock channel
The Catholic Charismatic Renewal (CCR): an Historical Analysis Between US and Europe (CAT-CAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

The research project aims to analyze the history of the Catholic Charismatic Renewal (CCR), a spiritual awakening movement which was founded in 1967 in the United States of America within the Catholic Church and which spread rapidly throughout the world, so much so that today its has more than 120 million members. The proposal intends to focus on three specific objectives: 1. to survey the relationship between US Catholicism and European Catholicism through the history of the CCR; 2. to analyze the reaction of the Catholic Church hierarchy to the CCR, especially that of the pontiffs, through the analysis of official pronouncements made during meetings with the charismatic groups or at other specific times; 3. to problematize the issue of gender within Catholicism defining the role of women within the CCR. The research can generally be considered to be a part of World/Global Christianity Studies, seen from a cross-cultural perspective. It foresees the use of archive material (Notre Dame Archives) and the first historiographical, sociological and theological texts on the CCR as primary sources in approaching the history and nature of the charismatic movement in understanding its origin, evolution and success, firstly in US and then in Europe. The topic is particularly auspicious from the point of view of academic exchange between Europe and the United States, as it serves as a moment of reflection and dialogue on the theme of the history of Christianity. There being no expert on the subject of the charismatic movement in the Catholic Church at any of the European universities, this research project could be a unique opportunity to forge personal career possibilities and new international contacts. Finally, the project would contribute to the History of Christianity, Studies in World Christianity, American Catholic Studies and European History on an international level.

Keywords: world christianity,history of catholicism
Temperature reconstruction in Europe using cosmogenic noble gas observations (TRENGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Temperature Reconstruction in Europe using cosmogenic Noble Gas Observations (TRENGO). I propose to reconstruct temperatures during the Late Quaternary (from within the last glacial cycle (LGC) to the present) using observations of cosmogenic noble gases in bedrock depth profiles at two key sites in Europe: the southernmost British Isles, and the southern coast of Spain. These two sites span the range of latitudes in Europe that were ice free during the LGC; temperature reconstructions at these sites will therefore capture endmembers of climate along the Atlantic margin of Europe during the LGC and deglaciation. Constraints on past climate conditions in these two regions from conventional proxies like pollen are largely restricted to the Holocene and ubiquitously mired by human influence. The temperature reconstructions proposed here could therefore provide unprecedented insight into long term climate dynamics over western Europe. I pioneered the use of cosmogenic noble gas observations for temperature reconstruction during my PhD and am thus uniquely suited to pursue this work. The Scottish Universities Environmental Research Centre within the University of Glasgow is one of the few institutions on Earth with the analytical capability and expertise to allow me to achieve the research aims of this proposal in full, and I will acquire new technical skills in cosmogenic radionuclide analysis essential to my future career. The research results will be disseminated in several international conference presentations publications in top tier journals and communicated through several different outreach activities in Glasgow.

Keywords: cosmogenic nuclide,noble gas,temperature,climate proxy,quaternary,holocene,last glacial cycle
Brain Performance Enhancement Revolution - Advanced Cognitive Training System for Football Players (BrainPEER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 2666875.0
EU funding (EUR): 1866812.5
Participants: 1
Project status: CLOSED

The BrainPEER project aims at presenting a highly effective brain-training system for football players. It will do so by adopting ACE’s patented Cognitive Simulation technology to football, demonstrating it with elite football academies, then run field trials with individual youth players. Football is the world’s most popular sport. Due to its competitive nature, football players of various ages are in a constant quest to improve their game and win. Some aspire to reach fame and financial prosperity. Others seek higher social status and acceptance. That aspiration is intensified by the extensive media coverage of elite athletes. According to football experts, the main differentiating skill between good football players and average ones is game intelligence. Alas, there are currently no effective tools to improve this critical aptitude. ACE proposes an innovative and highly effective cognitive training program, addressing football-related cognitive skills such as spatial awareness, anticipation, and decision making. The outcome of the project will be a market-ready brain-training product for football players of all ages and skill levels – the Football IntelliGym. The program is designed as a friendly video-game, will be compatible with mobile devices, and at an affordable price. The Football IntelliGym’s target market is 265 million football players, of which 61 million are in Europe. ACE is a pioneer and market leader in the field of cognitive training for athletes. It has already proved the concept both technologically and commercially - with ice-hockey in North America. ACE’s strategy is to present its revolutionary training concept in sports first, where performance is highly visible and constantly quantified. This will pave the way to presenting effective brain trainers for other complex and cognitive-challenging professions such as first-responders, medical staff, operators of control centres (e.g. airport controllers and smart city officers), and drivers.

Keywords: sport,football,soccer,performance enhancement,training,fitness,cognition,cognitive training