Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Virtual Centre (PJ32-W3 VC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Spain,Ireland,Italy,Italy,Switzerland,Belgium,Croatia,Hungary,Lithuania,Slovakia,Sweden,Norway,Poland,Belgium,France,France,Czechia,Denmark,United Kingdom
Call: Virtual Centre (H2020-SESAR-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-05-31
Duration (months): 29.0
Total project cost (EUR): 15214484.25
EU funding (EUR): 5579565.38
Participants: 32
Project status: SIGNED

PJ32-W3-01 Virtual Centre - Complement of PJ10-W2-93 Delegation of airspace amongst Air Traffic Service Units (ATSUs). While PJ10 W2-93 addresses the ATC aspects of airspace delegation amongst ATSUs, this solution will further investigate the Air Traffic Flow and Capacity Management (ATFCM) aspects of such airspace delegation amongst ATSUs. This proposal addresses also the need to develop the technical infrastructure to support the validation activities planned by SESAR2020 Wave 2 solution PJ10-W2-93 on the ATC aspects of airspace delegation amongst ATSUs and the validation activities required on the ATFCM aspects of airspace delegation amongst ATSUs.

Keywords: virtual centre,airspace delegation,air traffic service unit,atm data service provider,virtualisation,de fragmentation,digitalisation,intertoperability,airspace architecture study,sesar
Synergistic Gold Carbene Catalysis (SYNCAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-07-18
End date: 2018-07-17
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

We will develop new dual catalytic reactions based on the complementary reactivity of gold (I) and other transition metals. We will perform well developed gold-catalysed isomerisation reactions and intercept carbenoid intermediates through a transmetallation event with a more redox active metal such as palladium (0). Following this the resulting palladium carbenoid will perform a variety of cross-coupling reactions including: dimerisations, C-X insertions and C-H insertions. This approach has not been reported previously and would provide new reactions and disconnections for the synthetic chemist. This project will be delivered by Dr Tapas Ghosh, a highly experienced and accomplished researcher currently working at Izmir Institute of Technology, Turkey.

Keywords: gold,dual catalysis,rearrangements,cross couplings
Developing Therapeutic Antibodies for Pets (CAESAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic inflammatory diseases in pets such as Inflammatory Bowel Diseases (IBD) are poorly managed causing emotional and financial distress to pet owners. Current therapies are ineffective - they do not relieve pet suffering and lead to the animal being put down. Therapies are also expensive with costs up to €400/month. Antibody therapy for such conditions has long been used in human medicine but has not been sufficiently developed for veterinary medicine and causes an immunogenic response as the antibodies are not species specific. Antibodies need to be adapted which is expensive and causes severe side effects making them an untenable solution at present. Pet ownership in the EU has been on the increase (up by 2million pets since 2016) due to demographic shifts and a greater reliance on pets as companions. The global animal health market is worth > €29Bn growing at a CAGR of 6% with pet health making up 40% of the market. Pet owners spend €3k - €5k/ year on their pet’s health and are willing to pay to ease pet suffering. adivo is a German biotech company specializing in generating species-specific therapeutic antibodies for companion animals. adivo was founded in 2018. The adivo-team aims to address medical needs in dogs including cancer and chronic inflammation, with the potential of expanding activities into the development of therapeutics for other species in future. adivo has developed CAESAR, the first of a kind synthetic canine phage-display library to generate therapeutic antibodies for dogs. We have developed a complete library from which we can synthesize therapeutic antibodies native to treat IBD. Our solution will overcome the challenges of current therapies and provide an affordable, scalable solution for effective antibody therapy for pets which has been demonstrated in human medicine. We expect to generate out-licensing revenue ≥€15M when we launch the product before royalties and hire 12 people.

Keywords: veterinary medicine,antibody therapy,chronic inflammatory diseases,irritable bowel disease,canine health,phage display technology,canine antibodies,therapeutic antibodies
Innovative oxygen-free wine bottling process (RiCaMo)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-07-01
End date: 2018-03-31
Duration (months): 21.0
Total project cost (EUR): 1253875.0
EU funding (EUR): 877712.5
Participants: 2
Project status: CLOSED

The equilibrium between senses and biochemistry of wines can be compromised by the presence of a residual amount of oxygen inside the bottles, affecting the wine microbiology equilibrium and its conservation. In fact, the bottling phase is considered as one of the most critical steps in the entire winemaking process because it can affect the wine quality and features with severe economic consequences for the entire business. Furthermore, the use of sulphites and other preservatives in food and beverage industry currently represents a critical issue, due to their unwanted health effects. With the aim to improve the overall wine making sustainability, during the last 2 years the “foodtech” start-up company D.R. WINE Tech, supported by ENTER, developed an innovative bottling technology system: RiCaMo. This technology drastically reduces the amount of residual oxygen in the bottle through a patented retractable straw system under gaseous nitrogen, allowing to: -monitor the oxygen content during all the filling phases -reduce the amount of preservatives, like sulphites (-30/60%) and other additives -produce a high-quality wine with a longer shelf life -improve bottling volume scale-up of 25% -reduce wastes (-15% in terms of wine product and glass bottles) -foster the biological, biodynamic and natural wine production -support also small producers -meet the needs of wine makers, retailers, experts and consumers, at international level RiCaMo innovative filling machine has reached TRL7 and the 14 months European project will bring it to a comprehensive industrialized wine bottling system, through 6 pilots to exploit and test the machine for its market uptake, besides the validation of different business models (direct sale, mobile service and rental). RiCaMo will reach the European and global market within 3 years, providing 32% ROI and about € 1.130.000 turnover by 2022 for D.R. WINE Tech, considering about 70 sold RiCaMo machines and 200 rentals.

Keywords: product quality,cost savings,market uptake,water saving,food and drink processing,feasibility analysis
Synthesis and Formulation of Nanoparticles for pinning in YBCO coated conductors (SynFoNY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Finland,Belgium
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 499776.72
EU funding (EUR): 499776.48
Participants: 5
Project status: CLOSED

The main research objective is the formulation of new types of multimetaloxide nanocrystals for incorporation as artificial pinning centers in nanocomposite thin films processed using chemical solution deposition. Superconducting coated conductors are chosen as the proof of concept. Innovative chemical deposition methods and the incorporation of preformed and inert multimetaloxide nanocrystals as pinning centres into the superconducting nanocomposite thin film are the innovative aspects compared to ongoing research. A successful realisation of the objectives of this EID proposal will need training of ESRs on different aspects ranging from chemical precursor design, stabilisation of nanocrystals in precursor solutions, continuous deposition of superconducting nanocomposite coatings and optimisation of the superconducting properties in alternating magnetic fields. The main objective of this programme is, in line with the EID scope, to enhance the career perspectives of early stage researchers (ESRs) by providing the unique opportunity to be exposed to research and training in both an academic as well as an industrial environment. This will be facilitated through the partnership between Ghent University and the industrial partner Deutsche Nanoschicht GmbH, bringing together two widely respected research partners, active in the field of inorganic nanomaterials synthesis and coating development for improved superconducting wires for energy applications. The involved partner organisations entered the project for specific added value in terms of industrial scaled synthesis of nanocomposite precursors (hte GmbH: high troughput designs; BASF SE: new formulations and flow chemistry) and Univ. of Turku (physical characterisation).

Keywords: multimetaloxide nanocrystals,chemical solution deposition,nanocomposite chemical formulation,superconducting coated conductors,pinning
Mapping the functional connectome for speed control in spinal motor circuits (FunCoSpeedSpine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The study of spinal circuits underlying locomotion has a rich history, spanning over 100 years of research. Great efforts have been made to map out the connection patterns between motor neurons and different muscle targets. Yet, we know little about how premotor networks govern the recruitment of motor neurons and the control of speed. Recent advances in optogenetics, 3D light patterning and fluorescent-targeted patch clamp recordings of identified neurons now enable to map the functional connectome for speed control in spinal motor circuits. Here we will focus on the role of V2a excitatory premotor interneurons since these cells have the potential to act as a key nexus in the spinal network: i) spanning both in the hindbrain and spinal cord, ii) making direct connections with motor neurons and iii) modulating locomotor speed. Recent studies revealed piecemeal information related to the V2a to motor neurons connection pattern. By taking advantage of the optical clarity of the zebrafish larva, we will implement a comprehensive approach combining in vivo electrophysiology, state-of-the-art 3D optical stimulation of genetically targeted cells and functional calcium imaging to resolve the connectivity map of V2a neurons and answer 3 new key questions: 1. What are the synaptic connections among V2as and between V2a and motor neurons within both slow and fast locomotion? 2. What is the degree of convergence and divergence between V2a neurons and motor neurons? 3. Do supraspinal inputs to the spinal cord segregate based on speed? A talented young scientist, with a great track record and the right expertise to tackle these ambitious questions, will carry out the project in the prolific research environment offered by the Wyart lab at the Brain and Spine Institute in Paris. This effort will lead to high impact publications as well as to develop the necessary skills to launch an independent research career for the applicant.

Keywords: locomotion,connectome,optogenetics mediated mapping,zebrafish
Deciphering the computations underlying visual processing: Repurposing of retinal cells and how they are decoded by the visual thalamus (RetinalRepurposing)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 1494000.0
EU funding (EUR): 1494000.0
Participants: 1
Project status: SIGNED

Visual processing begins in the retina, with ~30 types of retinal ganglion cells (RGCs), each encodes a specific visual modality, such as edges or motion. A major challenge for deciphering the visual code is mapping the connections between each RGC and its target neurons, such as in the lateral geniculate nucleus (LGN) and, via the LGN, the visual cortex. Recently, this challenge became even greater, as we and others revealed that the modality encoded by RGCs—traditionally considered a fixed hardwired property of each RGC type—can be altered. Direction selective RGCs reorient their directional tuning following visual adaptation, and other RGCs change their polarity preference (On/Off) as light level changes. These newly discovered dramatic changes in the core computations of RGCs depart from the known retinal adaptation which results in gain adjustments but no modality changes. We term them repurposing. The discovery of repurposing contrasts the widely-held notion that the retina provides a stable representation of the visual scene for downstream processing. This newly exposed level of complexity in the retinal code raises a critical question for our understanding of vision: How do retinal targets interpret the dynamic retinal code and how, despite such dynamics, a consistent representation of the visual scene emerges? We will use state-of-the-art electrophysiology and imaging techniques, and pioneer an approach for simultaneous retinal imaging and LGN recordings, to reveal how the mouse early visual system processes the changing visual information. We will elucidate the subtypes of repurposed RGCs, triggers for repurposing and their mechanisms. We will resolve, for the first time, the precise functional connectivity between subtypes of RGCs and LGN neurons, and determine how the LGN decodes retinal repurposing. Our groundbreaking research will pave the path for understanding how visual processing in a constantly changing world gives rise to a consistent perception.

Keywords: retina,retinal ganglion cells,two photon imaging,electrophysiology
3D-PRintable glass-based Electrolytes for all-Solid-State lithium batteries (3D-PRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-02
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The main goal of the 3D-PRESS project is to advance in the 3D printing concepts for safer, cheaper and customizable all-solid state Li-ion batteries (LIB). More specifically, the project is focused on the design, production, characterization and testing of 3D printed NASICON-type glass-based electrolytes for 3D printed batteries. In 3D-PRESS, glass-based compositions will be designed and synthesized in order to obtain printable glass-based electrolytes with superior conductivity and functional properties. The produced glasses will be thermally and electrochemically characterized in order to investigate their sinter-crystallization behaviour (tailoring suitable sintering treatments) and electrochemical performances. The most promising electrolyte compositions will be selected to be printed in free-form robust self-standing structures in order to obtain 3D batteries with high active area (allowing high specific energy and power per unit volume). 3D-PRESS represents a cutting edge multidisciplinary approach for the development of reliable and customizable all-solid state 3D LIBs, especially interesting for micro-power applications such as the ones for Internet of Things (IoT). The project will provide a new family of printable materials increasing the short list of available compositions, especially solid electrolytes, opening the door to the development of a new generation of fully printable all-solid state 3D LIBs. A high impact on the future career of the candidate is expected by complementing his current background with new skills in one of the more relevant Key Enabling Technologies (KETs), 3D-printing, applied to the crucial field of the Energy Storage. Moreover, the host institute will offer unique opportunities to re-enforce the technology transfer competences of the candidate by carrying out an industrial secondment and by the involvement in the KIC Innoenergy community.

Keywords: all solid state battery,3d printing,electrolyte,glass ceramic,lithium ion battery,3d battery,3d lib
Holistic Deep Modelling for User Recognition and Affective Social Behaviour Sensing (HOL-DEEP-SENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2022-07-01
Duration (months): 30.0
Total project cost (EUR): 199828.2
EU funding (EUR): 199828.2
Participants: 3
Project status: CLOSED

The "Holistic Deep Modelling for User Recognition and Affective Social Behaviour Sensing" (HOL-DEEP-SENSE) project aims at augmenting affective machines such as virtual assistants and social robots with human-like acumen based on holistic perception and understanding abilities. Social competencies comprising context awareness, salience detection and affective sensitivity present a central aspect of human communication, and thus are indispensable for enabling natural and spontaneous human-machine interaction. Therefore, with the aim to advance affective computing and social signal processing, we envision a "Social Intelligent Multi-modal Ontological Net" (SIMON) that builds on technologies at the leading edge of deep learning for pattern recognition. In particular, our approach is driven by multi-modal information fusion using end-to-end deep neural networks trained on large datasets, allowing SIMON to exploit combined auditory, visual and physiological analysis. In contrast to standard machine learning systems, SIMON makes use of task relatedness to adapt its topology within a novel construct of subdivided neural networks. Through deep affective feature transformation, SIMON is able to perform associative domain adaptation via transfer and multi-task learning, and thus can infer user characteristics and social cues in a holistic context. This new unified sensing architecture will enable affective computers to assimilate ontological human phenomena, leading to a step change in machine perception. This will offer a wide range of applications for health and wellbeing in future IoT-inspired environments, connected to dedicated sensors and consumer electronics. By verifying the gains through holistic sensing, the project will show the true potential of the much sought-after emotionally and socially intelligent AI, and herald a new generation of machines with hitherto unseen skills to interact with humans via universal communication channels.

Keywords: affective computing,social signal processing,computational paralinguistics,deep learning,multi modal fusion,multi task learning,human machine interaction