Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breaking the curse of dimension in heavy-element chemistry (PCCDX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-03-09
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

The acute toxicity and radioactivity of actinide compounds complicate experimental studies of the “soup” of nuclear waste produced in nuclear reactors. This motivates research into computational approaches for determining molecular properties and reactivity of actinide compounds. Unfortunately, the computational resources required by standard quantum chemistry methods grow exponentially with system size, an effect known as the curse of dimension. Since the actinide-containing molecules of relevance to nuclear chemistry contain hundreds of electrons, innovative new approaches that break the curse of dimension must be developed. One such approach models many-electron molecules as collections of noninteracting electron pairs, called geminals. Standard geminal methods are inappropriate for actinide chemistry, however, and must be extended to include (i) computationally efficient ways to account for relativistic effects, (ii) correlations between electrons beyond electron-pairing effects (weak correlation), (iii) electronically excited states, and (iv) the description of unpaired electrons. Specifically, weak correlation will be captured using Coupled Cluster-type approaches, excited states are accessible through an Equation-of-Motion formalism, and open-shell extensions will use generalized quasi-particles as building blocks for the electronic wavefunction. The extended geminal models thus developed will provide the first direct, atomistic, and quantitative computational model for understanding nuclear waste reprocessing and will provide the essential insights that are needed to guide the synthesis of new actinide compounds that can be used to separate actinides from the other components in the “soup” of nuclear waste. The developed models will be robust, computationally cheap, and black-box-like and can be used in many other areas of chemistry and materials physics like lanthanide and transition-metal chemistry, biochemistry, and semiconductor physics.

Keywords: electron correlation,geminals,relativistic effects,excited states,actinide chemistry,open shell molecules,coordination chemistry,coupled cluster theory
OPENJOY (OPENJOY)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OPENJOY addresses the opportunity of providing a new sealing system for beer, cider and carbonated soft drinks filled in glass bottles. Closure and caps global market is a huge market increasing 5.6% CAGR per year to €44 billions in 2019. At present, this market is dominated by the crown cap, which after than 120 years remains almost unchanged in its format, despite it presents two significant counterparts: 1) it is not re-closabe, contributing to the problem of drink-waste; and 2) it depends of an external tool (opener) to work, implying dozens of tonnes of metal used in the manufacturing of openers that could be saved in the event an easy-open alternative to crown caps rises. Despite the existence of alternatives, like the screwcap (able to provide both easy-opening and re-closability) crown cap remains the No.1 glass bottle closure in the beer, cider and carbonated soft drinks industry. Reasons to this are to be found in two main aspects: 1) Bottle neck compatibility: crown cap finish is the most extended bottle neck type in industry. Changing product lines massively to other alternatives, like screwcaps, means huge investments in the entire substitution of machines. 2) Price per unit: crown cap are as low as €0,01/unit, whilst screwcaps and other similar alternatives go above €0,05/unit. Based on this opportunity, we have developed OPENJOY, an eco-innovative, easy-open, low-cost, crown cap compatible sealing system, using a revolutionary opening mechanism: your finger. It provides outstanding advantages: 1) cost less than €0,03/unit; 2) does not need of opener, 3) it is 100% compatible with existing crown caps sealing and bottling machines; 4) it is reclosabe. We plan to undertake detailed studies for identifying key actions points for the internationalization and fine-tuning of OPENJOY to make it a global success, purposes of Phase 2, for which we estimate a total budget of 1M€ for 1 year. In Phase 3 we will focus in further private investment.

Keywords: business plan,new product development,new closure system
Benchmark Exercise on Safety Engineering Practices (BESEP)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Finland,Slovakia,Hungary,Sweden,France,Czechia
Call: Safety margins determination for design basis-exceeding external hazards (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-06-30
Duration (months): 46.0
Total project cost (EUR): 2759701.25
EU funding (EUR): 2759701.25
Participants: 7
Project status: SIGNED

The objective of BESEP (Benchmark Exercise on Safety Engineering Practices) is to support safety margins determination by developing best practices for safety requirements verification against external hazards, using efficient and integrated set of Safety Engineering practices and probabilistic safety assessment. The benchmark exercise will: - Define a benchmark baseline on safety requirements important for the licensing of nuclear power plant new builds and upgrades. - Collect and group case studies on safety analysis of external hazards previously performed by the project partners. - Perform comparison of case studies and generalized case study groups from viewpoints of safety margins determination, requirements verification, level of details in safety analysis and realism in quantification of safety margins. - Evaluate possible successes and challenges of the applied Safety Engineering processes. - Evaluate resilience of safety margins in case of design-basis exceeding external hazards. - Evaluate the balance between the allocated analysis resources and the plant level risk significance of different external hazards using results from probabilistic safety assessments. - Disseminate results to the nuclear community taking into account both senior and junior technical experts as well as managers and policy makers. The main outcomes of BESEP will be: - Best practices for the verification of evolving and stringent safety requirements against external hazards - Guidance on the closer connection of deterministic and probabilistic safety analysis and human factors engineering for the determination and realistic quantification of safety margins. - Guidance on the creation of graded approach for the deployment of more sophisticated safety analysis methods, such as upgrades of simulation tools, while maintaining the plant level risk balance originating from different external hazards.

Keywords: safety requirements verification,safety margins,safety engineering,probabilistic safety analysis,deterministic safety analysis,human factors engineering
Add-on module for optical coherence tomography with en-face view option (AMEFOCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 149917.0
EU funding (EUR): 149917.0
Participants: 1
Project status: CLOSED

By the end of the 4th year of the ERC Advanced grant, the PI has set up the basis of a unique procedure to perform optical coherence tomography (OCT) that is similar in outcome to time domain interferometry but has all advantages of spectral domain interferometry in terms of speed and sensitivity. The new method of OCT, termed as Master/Slave (MS), is characterised by several advantages: direct production of an en-face OCT image, tolerance to dispersion that allows MS-OCT to achieve the theoretical limit of axial resolution and sensitivity that can be tailored for no hardware and time cost, with the axial resolution. By excellence, the Master/Slave OCT method delivers en-face views direct, allowing lower cost hardware and faster provision of en-face slicing and visualisation. An essential advantage is that of parallel processing, that makes MS-OCT, ideally suited to novel parallel optical configurations and graphic processing units (GPU). These advantages can substantially increase the speed in providing volumes of the tissue, making the new OCT method superior to all other methods on the market. The POC support will help advance the MS-OCT closer to commercialisation. Four market strategies are identified with immediate products for the first two. OCT add-on modules, equipped with MS software, for: A. OCT developers, to accelerate their research and B. OCT developers that can modify existing commercial OCT systems, by making them accomplish the MS protocol. The module to be assembled and assessed for commercialisation will also pave the way to two more strategies: C. Companies already selling OCT systems on dedicated markets, where specialised agreements will widen the market and even D. A full OCT system created by the new company, an ultimate outcome that requires investment, based on revenue acquired by selling the add-on modules.

Keywords: optical coherence tomography,en face imaging,3d rendering
Echoes of Vanishing Voices in the Mountains: A Linguistic History of Minorities in the Near East (ALHOME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 1997800.0
EU funding (EUR): 1997800.0
Participants: 1
Project status: SIGNED

Mesopotamia is the home of remarkably diverse ethnoreligious and linguistic microcommunities with historical roots in the ancient Near East. Jewish and Christian minorities with their own unique Ara-maic traditions have co-existed alongside mainly Iranian speech communities for millennia. Today the origin and development of this rich cultural-linguistic mosaic remains elusive due to superimposed nationalisms and paucity of historical records. ALHOME aims to reconstruct the complex, socioreligious past of the disappearing indigenous communities who were once more widespread across West Asian from the first millennium BC well into the Islamic period. Studying their genetic and social interrelations through their linguistic traditions will radically change our ideas about their origins. Using linguistic evidence hitherto untapped for this aim, we can untangle the intertwined his-tories of Jewish, Christian and Kurdish (i.e., Iranian) communities. This evidence comes from the recently richly enhanced database of spoken Neo-Aramaic languages which stretch back 3,000 years. This promises to mark a sea change in linguistic studies which have focused on the documentation of endangered languages as well as in sociological studies that have focused on the historical context giving rise to nationalisms. For the first time an interdisciplinary team of both Aramaic and Iranian specialists and computational linguists will study the interactions between two speech communities. We will apply groundbreaking quantitative, phylogenetic models to unearth relations between speech communities over millennia. Studying this period of multiculturalism and multilingualism of virtually unparalleled duration promises to challenge existing models of contact. Aramaic-Iranian exchanges fit into models based neither purely on linguistic-cultural prestige nor on agentivity of a single language. Thus ALHOME will have major implications for our understanding of areal convergence and contact.

Keywords: mesopotamia,iraq,aramaic linguistics,iranian linguistics,computational historical linguistics,areal linguistics,social history
Improving the Financeability and Attractiveness of Sustainable Energy Investments in Photovolatics: Quantifying and Managing the Technical Risk for Current and New Business Models (Solar Bankability)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Belgium
Call: Improving the financeability and attractiveness of sustainable energy investments (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 1355106.0
EU funding (EUR): 1355106.0
Participants: 5
Project status: CLOSED

The overall objective of this proposal is to reduce the risk associated with investments in sustainable energy projects. The project results should increase trust from investors, financers and insurance companies. The project aims to establish a common practice for professional risk assessment based on technical and financial due diligence. The focus is on photovoltaic (PV) installations, with emphasis on projects on buildings or at the customer side of the electricity consumption meter and financed by professional investors. The project pursues the following specific objectives: - To develop, document and establish practices for evaluating and mitigating the technical risks associated with investments in photovoltaics - To develop, document and establish practices for valuing such risks when modeling the costs of a PV investment as investors do when evaluating the life cycle costs of such projects - To evaluate how these risks affect the electricity production and the expected return on investment in different business models - To enable the key actors, and particularly the financial market actors, to widely adopt the project results as best practices for the mitigation of risk of sustainable energy investments with current and new business models. The project will be based on large amount of empirical data available within the consortium and from other projects, allowing to formulate recommendations that are statistically significant and based on a large evidence base. The project will involve all relevant stakeholders being financial market actors, valuation and standardization entities, building and PV plant owners, industry, energy prosumers and policy makers. The impacts to be achieved are reduced uncertainty, increased investors’ confidence and trust, valuation methodologies agreed by the market, standardized descriptions of investments, labelling schemes or harmonized frameworks for investment, and support to national strategies for financing.

Keywords: bankability,risk,investments,photovoltaics
Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens (KCs and Gut Antigens)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens. Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown. Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens. We hypothesise that KCs acquire intestinal antigens and subsequently modulate the immune response to these. Despite indications that KCs are involved, the lack of KC-specific tools has significantly hampered the study of these cells and to date their physiological role in modulating immune responses to intestinal antigens remains unclear. Here we propose to utilize novel and innovative tools including KC-specific knock-in (KI) mice generated by the host lab to specifically examine the role of KCs in antigen acquisition, presentation and determination of T cell fate. To our knowledge these tools represent the first of their kind and place us in a unique position to specifically examine the role of KCs in regulating the immune response to intestinal antigens. By combining murine modeling with analysis of human tissues in collaboration with the University Hospital, this project will greatly advance our understanding of the role of KCs and potentially uncover new therapeutic strategies in the prevention and/or treatment of disorders where the systemic immune response to intestinal antigens is dysregulated such as food allergies and inflammatory bowel diseases (IBDs).

Keywords: macrophage,liver,antigen presentation,intestine,kupffer cell,mononuclear phagocytes,t cell,oral tolerance
THE GENETIC BASIS OF MATING BEHAVIOR: PHEROMONE COMMUNICATION IN NOCTUID MOTHS (HELPHERGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-12-13
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The genetic architecture of behavior is a major topic in biology, but remains poorly understood. The behaviors with the most dramatic effect on animal fitness are those involved in mate attraction and courtship, which are directly related to reproductive success. Males and females share a genome but have idiosyncratic roles in courtship rituals; mating traits thus experience sex-specific selection regimes. Variation at the gene expression level can facilitate sex-specific trait evolution to some degree. However, sex-specific traits inevitably covary, leading to correlated evolutionary responses (pleiotropy). Here I propose an innovative and multidisciplinary framework integrating a quantitative genetic approach to multivariate phenotypic evolution with functional genetic experiments. The key objective is to reveal how genes controlling traits involved in mating behavior can have widespread phenotypic effects across sexes by quantitative genetic measurements of pheromone communication variation in wild-type and knock-out lines of noctuid moths. I will examine the correlated evolution of pheromone signals in male and female moths and identify candidate genes using differential expression analyses. Then, I will examine the phenotypic effects using the cutting-edge CRISPR/Cas9 system and a quantitative genetic framework to test behavioral effects. The proposed research combines behavioral, quantitative genetic, and gene editing techniques and will make headway towards understanding the genotype-phenotype map of mating behavior. I will be based at the Institute for Biodiversity and Ecosystem Dynamics (IBED), an excellent interdisciplinary research institute focusing on functional biodiversity at the University of Amsterdam (UvA). Via training-through-research and a secondment at a collaborative lab of the host supervisor, I will learn essential, state-of-the-art skills including genetic engineering, gene expression assays, and advanced bioinformatic scripting.

Keywords: sexual selection,olfactory mate choice,behavioral genomics
Nations Reversed. National Imaginaries, Images of Migration in Greece and Mexico (STREAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-15
End date: 2024-10-14
Duration (months): 36.0
Total project cost (EUR): 241808.64
EU funding (EUR): 241808.64
Participants: 2
Project status: SIGNED

As migratory movements surge around the world, Greece and Mexico, two countries located at the doorstep of Europe and the United States, face the challenges of demographic changes. Among the many effects of migration on these nations, the presence of the migrant ‘other’ poses an interesting question: can the visual presence of otherness become a looking glass to redefines national ethos? STREAM anthropologically explores this conundrum by looking at different types of images, formal and informal, photographic, artistic, religious, animated and more – connected to migration, and to the figure of the migrant in both places. The comparison between these two nations is informed by their position as buffer zones on central migration routes and a similar geopolitical position, which is emblematic of the unequal political dynamics that separate the Global North from the Global South. Making a comparative analysis of these two countries through the examples of two regions, Crete and Oaxaca, which are at the forefront of migration flows, and are characterized by their relative independence from central governments as well as their status of internal "other", this study unlocks a sideway window into national imaginings. To do so, this research asks the following research questions: (1) Which kind of national imaginaries emerge when looking at images of migration? (2) What do these images reveal about local perceptions of national representation? (3) To what extent does this dialectical relation between nation and migration, seen through visual media, illuminate wider political international dynamics? Ultimately, STREAM’s objective is to generate innovative comparative research to enhance our understanding of the socio-political impact of images in reshaping national imaginings.

Keywords: nationalism,migration,visual and mulitmodal,anthropology,mexico,greece