Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A revolutionary Lithography-based Metal Manufacturing (LMM) machine for 3D printing of high-quality functional metal parts (LMM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The typical use of Additive Manufacturing (AM) for metals is to produce prototypes during product development and complex parts for pilot series. Whereas established industrial methods such as Metal Injection Molding (MIM) are used for the production of complex metal parts in high volumes. The design limitations and high tooling costs for casting or injection moulding also make conventional manufacturing unsuitable for customizable short series production of parts with high geometric complexity. AM is expected to address this need by speeding the production time without inflating the costs per part especially for applications such as dental restoration, aerospace, and automobiles. Despite a large need, high set-up costs, lengthy manual post-processing and unpredictable defects in final parts and products are preventing complete deployment and adoption of AM in the manufacturing of final products. Lithoz offers Lithography-based Metal Manufacturing (LMM), an innovative automated AM machine for 3D printing of advanced, high-quality metal products. Thanks to a proprietary ground-breaking AM technology, LMM enables to print any metal parts with any design and provides unequaled accuracy and quality of the final product. LMM can be easily implemented into existing Metal Injection Moulding (MIM) manufacturing lines without the need for dedicated postprocessing machinery and specialized expertise, thus enabling to reduce total production costs and time. During the phase 1 feasibility study, Lithoz will establish a sound go-to-market strategy and supply chain and will outline further development plans. During the innovation project, Lithoz will optimize the machine and printing process, validate it with partners in the MIM manufacturing industry, and obtain CE mark and regulatory compliance.

Keywords: additive manufacturing,3d printing,green parts,metal injection molding,vat photopolymerization,metal manufacturing
Surveilling Malaria through machine learning and clustering tools in pregnancy (PregMal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-12-21
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The vision of the World Health Organisation (WHO) for 2030 is a world free of malaria. For this, agile and robust malaria surveillance systems are required to efficiently guide actions towards interruption of transmission. Estimating malaria trends from passive detection of clinical malaria cases at health facilities or from cross-sectional surveys remains difficult and expensive. Pregnant women represent a promising convenience group for malaria surveillance, providing a representative section of the overall population in a cost-efficient and sustainable manner. Serological and molecular surveillance has also become a potential key approach to guide elimination efforts, providing information about the history of exposure, the geographic origin (malaria importation) and the intensity of malaria transmission. Here we propose to develop and apply novel statistical tools (adapted from the field of cosmology) to test an innovative and cost-efficient surveillance approach based on the strategic use of parasitological, serological and genomic data from easy-access pregnant women at antenatal care (ANC) clinics. The application of these new tools on data obtained from pregnant women can suppose an enormous breakthrough for sustainable and actionable surveillance systems that can accelerate efforts towards malaria elimination. With these new developed tools I will a) assess the potential of parasitological and serological data from pregnant women at first ANC visit as a source of reliable data to reflect temporal and spatial malaria trends in the community and b) compare genetic metrics in the parasite population of pregnant women and the overall community that can inform about changes of malaria transmission, clustering of infections and parasite importation.

Keywords: malaria surveillance,pregnant women,clustering,parasitology,plasmodium falciparum,asymptomatic infections,genomics,mozambique
Reconnecting transmission to global tuberculosis control by mapping pathogen transmission events to host infection status (TB-RECONNECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain,Spain,Mozambique
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 2723027.0
EU funding (EUR): 2035718.75
Participants: 3
Project status: SIGNED

The annual decline in tuberculosis (TB) incidence is not greatly different from that of the ‘90s, when no coordinated efforts in global tuberculosis control were in place. The failure of current TB control programmes to accelerate TB elimination has multiple causes, including losses of TB cases at the different steps of the TB care cascade, and a chronic lack of funding hampering innovation. Additionally, we have failed to halt transmission in many settings, as we have failed to incorporate our improved understanding of transmission in TB control programmes. Our current approach to controlling TB is focused on a narrow view of who is transmitting the disease (symptomatically active TB cases), while there is a growing consensus that the traditional latent/active dichotomy is no longer valid, and that asymptomatic individuals with active TB signatures are also likely to be transmitting the disease. There is a critical lack of high-resolution data from different settings on the contribution to the transmission burden of cases with different infection statuses. To fill this evidence gap, I propose synergizing three recent TB research developments; We can now use host blood transcriptomics to discriminate between infection status within the latent pool of individuals. We can now quantify transmission at a resolution not previously available, using pathogen genome sequencing. We can now use phylogenetic and epidemiological models to identify when transmission has happened. Combining these three key developments with TB cohorts from multiple settings, and available tools from bacterial population genetics, high-throughput functional genomics and infection biology, we will be in a key position to answer these burning questions about the nature of TB transmission and the host and pathogen biology behind this. More importantly, we will reconnect transmission to TB control, to inform major shifts in global and local control strategies.

Keywords: tuberculosis,epidemiology,global health,infectious diseases,pathogen genomics,host transcriptomics,infection models
Unravelling protein phosphorylation mechanisms and phosphoproteome changes under nitrosative stress conditions in E.coli (NOPHOS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Currently, we face a global antibiotic resistance crisis aggravated by the slow development of more effective and anti-resistance promoting therapeutical solutions. Protein phosphorylation (PP) has recently emerged as one of the major post-translational modification in bacteria, involved in the regulation of multiple physiological processes. In this MSCA individual fellowship application we aim to bridge the current gap in the field for prokaryotes by unravelling the unknown regulatory role of PP on proteins involved in nitrosative stress (NS) detoxification in the model bacterium E.coli. We propose to examine for the first time both global protein modifications (e.g. phosphoproteomics) under nitrogen species stress, as well as characterize PP in individual proteins involved in NS response. We will construct a network model that reflect the phosphoproteomic changes upon NS in E.coli, that may pave the way for the design of new bacterial targets. Understanding how bacteria respond to the chemical weapons of the human innate system is fundamental to develop efficient therapies. We will pioneer research on the mechanism and the regulation of nitric oxide detoxification proteins already identified as phosphorylated, by analyzing how this modification influences their stability and activity in vitro and in vivo. This project opens up new research paths on bacterial detoxification systems and signalling in general, addressing for the first time the role of PP in these processes. The proposal brings together transversal and scientific skills that will enable the researcher to lead the development of this emerging field and position herself as an expert in the area, and aims at establishing the importance of PP in NO microbial response, a novelty in this field.

Keywords: bacterial protein phosphorylation,nitrosative stress,flavodiiron,nitric oxide,reactive nitrogen species,iron sulfur proteins,transcriptional regulation
Topographically-driven meteoric groundwater – An important geomorphic agent (MARCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Malta,United States
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1757432.0
EU funding (EUR): 932612.25
Participants: 3
Project status: SIGNED

Topographically-driven meteoric (TDM) recharge is a key driver of offshore groundwater systems because sea level has been lower than at present for 80% of the last 2.6 million years. Groundwater has been implicated as an important agent in the geomorphic evolution of passive continental margins and the canyons that incise them. However, the geomorphic efficacy of groundwater remains dubious, and a diagnostic link between landscape form and groundwater processes remains poorly quantified, especially for bedrock and cohesive sediments. Obstacles that prevent going beyond the current state-of-knowledge include: (i) a focus on terrestrial contexts and a lack of mechanistic understanding of groundwater erosion/weathering; (ii) limited information on offshore groundwater architecture, history and dynamics. By addressing the role of TDM offshore groundwater in the geomorphic evolution of the most prevalent types of continental margins, MARCAN is expected to open new scientific horizons in continental margin research and bring about a step-change in our understanding of some of the most widespread and significant landforms on Earth. The project’s methodology is rooted in an innovative, multi-scale and multidisciplinary approach that incorporates: (i) the most detailed 3D characterisation of TDM offshore groundwater systems and their evolution during an integral glacial cycle, based on state-of-the-art marine data and hydrogeologic models, and (ii) the development of a comprehensive continental margin geomorphic evolution model, based on realistic laboratory simulations, accurate field measurements and advanced numerical solutions. By placing better constraints on past fluid migration histories, MARCAN will also have strong applied relevance, primarily by improving assessment and exploitation of offshore freshwater as a source of drinking water.

Keywords: geomorphology,groundwater,weathering,erosion,canyons,landscape evolution,continental margins
A new ICT-based device (RHEO-01) for fast point-of-care analysis of acute ischemic stroke and other emergency situations. (ERYTHROAG)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: France
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Stroke is the most frequent cause of long-term disability in Europe, mainly in middle-aged and elderly people. Stroke imposes a huge health care economic burden: >5B€/year in France. RHEOFAST is developing a smart ICT-based decision support tool to assist health professionals in the efficient management of patients with acute stroke. RHEO-01 information management includes three aspects: 1- High quality data input from a connected point-of-care device that measure a patient’s inflammatory profile in 30s. The optically measured erythrocyte aggregation kinetics (EA) varies with inflammation. This information is contextualized by the patient’s clinical characteristics provided by physicians. 2-Remote smart data is managed with EA kinetics mathematical modelling, comparison with proprietary dataset and dataset enrichment with high quality data, 3- Physician-friendly output is displayed on the POC device to help physicians make treatment decisions. The whole process from standard blood collection to results takes less than 5 minutes. Acute ischemic stroke triggers inflammation, which in turn alters EA kinetics. Hemorrhagic stroke doesn’t initially trigger inflammation. By helping physicians to quickly differentiate patients with acute ischemic stroke from patients with hemorrhagic stroke, RHEO-01 will improve the percentage of patients receiving timely life-saving thrombolytic therapy. A 1% increase in thrombolytic treatment translates to a 440K€ decrease in cost (France). Furthermore, RHEO-01 can quickly identify inflammatory profiles in patients with other emergency conditions. Based on the French situation RHEOFAST forecasts a rapid growing turnover starting in 2018 with up to 13 M€ after 5 years. We need to have a European approach to update our forecast and propose our solution to health professionals all across Europe. This is the objective of the ERYTHROAG project, which includes technical risk analysis, market research and freedom to operate study.

Keywords: connected medical device,medical decision support tool,acute stroke management
Accurate halo masses in the precision cosmology era (HALOS2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Weak gravitational lensing is a very powerful tool for investigating the relation between galaxies and their host dark matter halos. Thanks to current photometric surveys such as KiDS, DES and HSC, the quality of the data available for weak lensing studies is rapidly improving. However, there has not yet been a corresponding improvement in the methods used for the analysis of this data: most weak lensing studies are still carried out by stacking the signal in bins, resulting in a net loss of information. As an alternative to stacking, I have recently developed a new method to infer the distribution of halo masses of a population of galaxies with weak lensing data. The method, based on a Bayesian hierarchical inference formalism, allows for an easy exploration of correlations in many dimensions, and to directly constrain the intrinsic scatter in halo mass. In this project, I will use my method to look for correlations between halo mass and secondary galaxy properties at fixed stellar mass, such as the age of the stellar population, in KiDS data. I will first test the robustness of my method on hydrodynamical simulations. Then, after receiving a training on the most technical aspects of KiDS weak lensing measurements, I will apply it on real data. Finally, I will compare the results of my analysis with predictions from theoretical models. By detecting or ruling out correlations between halo mass and galaxy properties, I will be able to put powerful constraints on galaxy evolution models. This project will produce an immediate return in terms of science, and will pave the way for the use of more efficient analysis methods in future surveys such as Euclid.
The socio-economic consequences of temporary employment: A comparative panel data analysis (SECCOPA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 1393560.99
EU funding (EUR): 1393560.99
Participants: 1
Project status: CLOSED

Temporary employment has become widespread in industrialized nations and many concerns have been raised about this development. Against this background, we will provide new insights into the multi-faceted socio-economic consequences of temporary work. Theoretically, this project is innovative by developing a multilevel dynamic model that combines ideas from sociology, economics, psychology, and social policy. Specifically, we will gain a novel, comprehensive understanding of how temporary jobs affect the employment and work career, risks of income poverty and material deprivation, and subjective well-being. This project aims at estimating causal effects of temporary work using panel data and applying state-of-the-art methods of modern causal analysis. Complementing the dominant “upward” comparison of temporary jobs to permanent ones with a “downward” comparison of temporary jobs to unemployment has the potential for producing ground-breaking results on the integrative potential of temporary work for the unemployed. Furthermore, new evidence on the heterogeneity in the effects of temporary employment at the micro-level will be gained by conducting detailed subgroup analyses. Moreover, this project will advance research by elaborating the socio-economic consequences of temporary employment in a dynamic process and life course perspective. The selection, treatment, and outcome dynamics are investigated by following temporary workers and their household living arrangements over time. While previous studies have only focused on individual workers, the important household perspective and its moderating role will be elaborated, too. Analysing Western and Eastern European countries as well as the liberal welfare states Canada, the United States, South Korea, Japan and Australia and applying innovative multilevel panel data methods will result in significant new insights and represent frontier research on the moderating role of the structural and institutional macro context.
REspiratory Science Promoted by International Research Exchanges 4 (RESPIRE4)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Switzerland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2020-07-01
End date: 2026-09-30
Duration (months): 75.0
Total project cost (EUR): 3420540.0
EU funding (EUR): 1710270.0
Participants: 1
Project status: SIGNED

The European Respiratory Society (ERS) is the largest society of lung clinicians and scientists in Europe, with a growing international membership (more than 30,000 currently) in more than 160 countries. Its mission is to promote lung health and to drive globally standards for respiratory medicine. Since 1997, ERS has operated a wide portfolio of fellowships, promoting transnational mobility and career development of researchers within respiratory science. This included three Marie-Sklodowska Curie COFUND programmes (two under FP7 and one under Horizon2020). ERS is now proposing to build on the success and best practice developed during previous RESPIRE programmes and on an already established network of more than 100 host centres, through a new, next-generation RESPIRE4 scheme. The latter introduces further added value and innovative elements compared to the past, building on fellows' feedback and the external evaluation of the previous RESPIRE programmes. First of all, RESPIRE4 places major attention to flexibility for fellows via tailored secondment and extension schemes, notably in the non-academic sector. Second of all, the outreach and patient involvement components have been further strenghtened to enhance the impact of the programme. Third, a country coefficient criteria has been introduced to continue to attract the most promising researchers. Lastly, the programme integrates returnees from a career break as well as less represented countries (COFUND 2018 list) in its planning. RESPIRE Marie Sklodowska-Curie fellows will also benefit from extensive opportunities in terms of training and networking, notably via the ERS flagship events (Lung Science Conference & International Congress) and wider ERS network. Therefore, the proposed RESPIRE4 programme will contribute to foster the European Research Area by training the next generation of leaders in respiratory research, which remains significantly underfunded at European level.

Keywords: lung disease,respiratory research,inter sectoral exposure,european fellowship,global fellowship,career development