Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Agricultural Research for Development Dimension of the European Research Area (ERA-ARD II)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Coordination and support actions
Partnership: ERA-ARD II (ERA-NET)
Countries involved: Netherlands,Austria,Germany,France,France,Spain,Türkiye,Finland,Lithuania,Hungary,United Kingdom,Denmark,Portugal,Belgium,Italy,Switzerland
Call:  (FP7-ERANET-2009-RTD, 2009)
Start date: 2010-10-01
End date: 2013-09-30
Duration (months): 36.0
Total project cost (EUR): 1539881.6
EU funding (EUR): 971710.0
Participants: 18
Project status: CLOSED

ERA-ARD II has two strategic objectives: Improving the European contribution to International Agricultural Research (IAR) by promoting joint activities and trans-national programs in the field of Agricultural Research for Development (ARD). Increasing the impact of European contributions in achieving the Millennium Development Goals (MDG’s) and to sustainable growth in the poorest countries in the world. Achievements of ERA ARD I are: ERA-ARD provided a shared vision and a strategic agenda on ARD in Europe ERA-ARD provided an analysis of collaboration models to the implementation of joint and transnational activities ERA-ARD realised increased involvement of Southern partners through the establishment of a Southern Advisory Group ERA-ARD implemented a transnational call on “Bioenergy”. The areas for improvement are: Enlargement of the consortium by integrating new Countries (Portugal, Turkey, Finland, etc.). Expand joint and transnational activities initiated during ERA-ARD I Realise joint activities in the Thematic fields: Capacity development, Agri-Food Chain Security and Food &amp; Energy , also related to climate change Involve the end users of the European ARD programmes in the design and implementation of joint and transnational activities Expend the Southern Advisory Group to include stakeholders from all continents The impacts of this ERA-net lies in supporting and enhancing the European Research Area for Development. A greater contribution and visibility of Europe towards achieving the Millennium Development Goals through an increase in effectiveness and efficiency of its research for development programs will be established along with the development of a more coherent European ARD and a facilitated access of developing countries to European ARD expertise. The joint call (s) will result in research that will contribute to meeting the EU’s commitment towards the United Nations Millennium Development Goals.

Keywords: european contribution to the millennium development goals,agricultural research for development,demand driven research agenda's,joint activities and transnational programs,stakeholder involvement
Brain energy supply and the consequences of its failure (BRAINPOWER)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2016-03-31
Duration (months): 72.0
Total project cost (EUR): 2499946.8
EU funding (EUR): 2499946.8
Participants: 1
Project status: CLOSED

Energy, supplied in the form of oxygen and glucose in the blood, is essential for the brain s cognitive power. Failure of the energy supply to the nervous system underlies the mental and physical disability occurring in a wide range of economically important neurological disorders, such as stroke, spinal cord injury and cerebral palsy. Using a combination of two-photon imaging, electrophysiological, molecular and transgenic approaches, I will investigate the control of brain energy supply at the vascular level, and at the level of individual neurons and glial cells, and study the deleterious consequences for the neurons, glia and vasculature of a failure of brain energy supply. The work will focus on the following fundamental issues: A. Vascular control of the brain energy supply (1) How important is control of energy supply at the capillary level, by pericytes? (2) Which synapses control blood flow (and thus generate functional imaging signals) in the cortex? B. Neuronal and glial control of brain energy supply (3) How is grey matter neuronal activity powered? (4) How is the white matter supplied with energy? C. The pathological consequences of a loss of brain energy supply (5) How does a fall of energy supply cause neurotoxic glutamate release? (6) How similar are events in the grey and white matter in energy deprivation conditions? (7) How does a transient loss of energy supply affect blood flow regulation? (8) How does brain energy use change after a period without energy supply? Together this work will significantly advance our understanding of how the energy supply to neurons and glia is regulated in normal conditions, and how the loss of the energy supply causes disorders which consume more than 5% of the costs of European health services (5% of ~1000 billion euro/year).

Keywords: oligodendrocyte,neuron,mitochondria,ischaemia,capillary,pericyte
Large Scale Experiments on Core Degradation, Melt Retention and Containment Behaviour (LACOMECO)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Coordination and support actions
Countries involved: Germany
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-02-01
End date: 2013-01-31
Duration (months): 36.0
Total project cost (EUR): 783100.0
EU funding (EUR): 500000.0
Participants: 1
Project status: CLOSED

The objective of the LACOMECO project is to offer EU research institutions access to four experimental facilities QUENCH, LIVE, DISCO and HYKA which are designed to study the remaining severe accident safety issues, ranked with high or medium priority by the SARP group for SARNET. These issues are coolability of a degraded core, corium coolability in the RPV, possible melt dispersion to the reactor cavity, and hydrogen mixing and combustion in the containment. These facilities are unique in providing experimental programmes in specific fields of core damage initiation up to hydrogen behaviour, without rival in other Member States. The experiments are designed to be complementary to other European facilities and experimental platforms to form a coherent European nuclear experimental network. The project will bring together competent teams from different countries with complementary knowledge. Moreover, the links with the East European research organisations and utilities will be established and maintained. Therefore, the project will offer a unique opportunity to join networks and activities supporting VVER safety, and for Eastern experts to get access to large scale experimental facilities in a Western research organisation. They will thereby improve their understanding of material properties, core behaviour, and containment safety under severe accident conditions. These topics addressed are extremely complex and demand the specific research involving substantial resources; the research field is too wide to allow the study of all the phenomena by any national programme. To optimise the use of the resources, the collaboration between different EU institutions at both national and international levels is highly important. This is precisely the main objective of the LACOMECO project, which aims to provide these resources and to facilitate this collaboration by offering unique severe accident research facilities at the Karlsruhe Institute of Technology (KIT) for transnational access.

Keywords: severe accidents,core coolability,hydrogen behaviour
Novel technologies for enhanced energy and exergy efficiencies in primary aluminium production industry (ENEXAL)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy efficiency and savings
Action type: Collaborative project
Countries involved: Greece,Germany,Switzerland,Israel,Serbia,Italy,South Africa
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-06-01
End date: 2014-11-30
Duration (months): 54.0
Total project cost (EUR): 8471072.0
EU funding (EUR): 4948964.0
Participants: 10
Project status: CLOSED

Primary aluminium production industry is the world’s larger industrial consumer of energy and ranked among the most CO2 intensive industries. It also generates enormous quantities of wastes that further decrease the exergy efficiency of its production process. However, this industry is one of the most vital sectors from economic and social point of view, not only for EU but also for the entire world. In order to remain viable and competitive, primary aluminium industry has to operate in a smarter way, be more energy efficient and meet the environmental requirements of our times. This can be achieved only through radical new technologies and novel business strategies, which will enable the industry to maintain its competitiveness and fasten its viability in the world’s markets, and explore new business opportunities. The main goal of this project is to provide primary aluminium industry with “green” innovative technological and economical solutions, focusing on the: (i) significant improvement of energy and exergy efficiencies of the production process; (ii) substantial reduction of GHG emissions; and (iii) complete elimination of the solid wastes. In order to achieve this goal within the project, novel technologies for the reduction of alumina to aluminium and the complete utilization of the red mud will be demonstrated and validated in pilot-scale. These technologies are energy-efficient and environmental-friendly, ensuring the competitiveness of the industry. A site optimization study of the new industry, integrating the novel technologies, is expected to achieve further reduction of energy and CO2 emissions and improve the energy and exergy efficiency of the whole process. It is aimed that the novel technologies will play a key-role on the sustainability, competitiveness and viability of primary aluminium production industry, so as to render it a leader industry for energy-efficient technologies and products in Europe and worldwide.

Keywords: sustainable industrial production,primary aluminium production industry,carbothermic reduction of alumina,solar furnace,red mud treatment,ghg emission reduction,energy and exergy efficiency
A Think Tank Hosting an Interdisciplinary Network to provide Knowledge support to EU Energy Policy Making (THINK)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Knowledge for energy policy making
Action type: Coordination and support actions
Countries involved: Italy,France,Belgium,Spain,Italy,Hungary,Greece,Poland,Germany,Germany,Norway,Switzerland,Sweden,Belgium,Portugal,Germany
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-06-01
End date: 2013-05-31
Duration (months): 36.0
Total project cost (EUR): 2464401.5
EU funding (EUR): 2188848.1
Participants: 18
Project status: CLOSED

The three year coordinating action THINK will improve the knowledge support to policy making by the European Commission in the context of the Strategic Energy Technology Plan. THINK is organized around a multidisciplinary group of 24 experts covering five dimensions of energy policy: science and technology, market and network economics, regulation, law, and policy implementation. The Think Tank will respond to the European Commission’s evolving needs on a semester basis and produce 12 dossiers and a book. Each semester, two projects will go through the quality process of the Think Tank, including an expert hearing to test the robustness of the work, a discussion meeting inside the Think Tank, and a public consultation to test the public acceptance of different policy options by involving the broader community. Each Think Tank dossier will therefore include four chapters: 1) the Think Tank assessment of the energy policy options with clear recommendations for policy makers from the drafting team under guidance of the Project Leader, 2) a report including the comments from two Think Tank Advisors, 3) the expert hearing summary, and 4) the public consultation conclusions. The coordinating action THINK will reduce the costs related to the implementation of the ambitious EU energy policy targets by assessing the impacts of policy options using an innovative organisational and analytical frame. With a core group of about 15 nationalities, this coordinating action will also help counter the fragmentation of research in Europe and bridge the gap between Member States and the European Commission by creating a common knowledge base for decision making in energy policy.

Keywords: european strategic energy technology plan,impact assessment,public consultation,expert hearings
A molecular view of chromosome condensation (CHROMOCOND)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2015-03-31
Duration (months): 60.0
Total project cost (EUR): 2076126.2
EU funding (EUR): 2076126.2
Participants: 1
Project status: CLOSED

Eukaryotic cells inherit much of their genomic information in the form of chromosomes during cell division. Centimetre-long DNA molecules are packed into micrometer-sized chromosomes to enable this process. How DNA is organised within mitotic chromosomes is still largely unknown. A key structural protein component of mitotic chromosomes, implicated in their compaction, is the condensin complex. In this proposal, we aim to elucidate the molecular architecture of mitotic chromosomes, taking advantage of new genomic techniques and the relatively simple genome organisation of yeast model systems. We will place particular emphasis on elucidating the contribution of the condensin complex, and the cell cycle regulation of its activities, in promoting chromosome condensation. Our previous work has provided genome-wide maps of condensin binding to budding and fission yeast chromosomes. We will continue to decipher the molecular determinants for condensin binding. To investigate how condensin mediates DNA compaction, we propose to generate chromosome-wide DNA/DNA proximity maps. Our approach will be an extension of the chromosome conformation capture (3C) technique. High throughput sequencing of interaction points has provided a first glimpse of the interactions that govern chromosome condensation. The role that condensin plays in promoting these interactions will be investigated. The contribution of condensin s ATP-dependent activities, and cell cycle-dependent post-translational modifications, will be studied. This will be complemented by mathematical modelling of the condensation process. In addition to chromosome condensation, condensin is required for resolution of sister chromatids in anaphase. We will develop an assay to study the catenation status of sister chromatids and how condensin may contribute to their topological resolution.

Keywords: chromosome condensation,mitosis,s. cerevisiae,chip and 3c analysis,dna catenation
Gasification of Biofuels and Recovered Fuels (GAS BIOREF)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Portugal,Greece,Belgium,Germany
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-12-01
End date: 2014-11-30
Duration (months): 48.0
Total project cost (EUR): 14449681.82
EU funding (EUR): 8339765.67
Participants: 6
Project status: CLOSED

This proposal aims to demonstrate the utilisation of a wide range of biomass feedstocks in an innovative energy conversion scheme. More particularly, it is proposed to convert equal proportions of app. 25000 tons/y of Solid Recovered Fuel (SRF), derived from a planned MSW recycling facility and biomass (from energy crops) to electricity and heat in a Bubbling Fluidized Bed (BFB) gasification power plant. This medium-scale co-generation project (fuel input approx. 13,5 MW) is expected to generate approx. 21 GWh of electricity; 45 GWh of thermal energy reaching an overall efficiency of 65%. SRF will be provided by an adjacent 50000 tons MSW/y recycling facility, currently in the design phase, in Imathia Prefecture (Central Macedonia, Greece), while biomass by locally grown energy crops. The proposal aims to demonstrate close-coupling of two different fuel supply chains (energy-crops and SRF), also addressing other important issues, such as: a) The capacity of the SRF-alone gasification facility is increased, whereby achieving significant economies of scale; b) The fuel security in the energy conversion facility is improved, due to the multi-feedstock approach adopted; c) The biomass incorporation in existing infrastructure is secured, providing a new market opportunity, i.e. its co-utilisation with recovered fuels (SRF) from MSW treatment. Thus, capital savings may be achieved since no additional equipment for biomass conversion is needed; the only investment required being the necessary infrastructure for biomass logistics. d) The efficient utilisation of waste heat in a process-integrated biomass dryer is achieved, leading to a significant improvement in overall energy efficiency. Recovered heat will also be used in the adjacent Wastes Treatment Facility (WTF) as well as for addressing additional energy services to the nearby community. e) The entire process chain for sustainable biomass feedstock (energy crops) supply at a medium scale application is demonstrated.

Keywords: biomass,energy crops,co-generation,srf
Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression (TARGETINGGENETHERAPY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Italy
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2016-01-31
Duration (months): 69.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 3
Project status: CLOSED

Hematopoietic stem cell gene therapy has a tremendous potential to treat human disease. Yet, in conjunction with the first successful results in the clinic, severe adverse events linked to the gene transfer protocol were reported. Recently, we provided proof-of-principle of two new powerful strategies to improve the efficacy and safety of gene transfer: 1) regulating transgene expression by exploiting cellular microRNAs; 2) targeting integration at predetermined sites of the genome by forcing homologous recombination with designer Zinc finger nucleases. Here we will investigate the microRNA network regulating hematopoiesis and exploit the new knowledge to develop vectors with stringently controlled expression throughout the hematopoietic lineages. We will develop Zinc finger nuclease-based vectors that insert the transgene with high efficiency and specificity either downstream to its own endogenous promoter or into a safe genomic harbor that allows for robust expression without interference on the neighboring genes. By combining these strategies we will provide radically improved gene transfer platforms. Furthermore, we will exploit these technologies for the generation and genetic correction of induced pluripotent stem cells, providing a potentially unlimited source of patient-derived vector free gene corrected multipotent stem cells for future applications of regenerative medicine. The new gene therapy strategies will be tested in pre-clinical models of leukodystrophies and immunodeficiencies, for which we have extensive experience, and should enter a clinical trial for at least one such disease by the end of the proposed funding period. If successfully validated, the new strategies may eventually broaden the scope of gene therapy in medicine.

Keywords: lentiviral vectors,microrna,zinc-finger nuclease,leukodystrophies,chronic granulomatous disorder,ips (induced pluripotent stem cells)
Design principles and controllability of protein circuits (DEPICT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Israel
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-03-01
End date: 2015-02-28
Duration (months): 60.0
Total project cost (EUR): 2261440.0
EU funding (EUR): 2261440.0
Participants: 1
Project status: CLOSED

Cells use circuits of interacting proteins to respond to their environment. In the past decades, molecular biology has provided detailed knowledge on the proteins in these circuits and their interactions. To fully understand circuit function requires, in addition to molecular knowledge, new concepts that explain how multiple components work together to perform systems level functions. Our lab has been a leader in defining such concepts, based on combined experimental and theoretical study of well characterized circuits in bacteria and human cells. In this proposal we aim to find novel principles on how circuits resist fluctuations and errors, and how they can be controlled by drugs: (1) Why do key regulatory systems use bifunctional enzymes that catalyze antagonistic reactions (e.g. both kinase and phosphatase)? We will test the role of bifunctional enzymes in making circuits robust to variations in protein levels. (2) Why are some genes regulated by a repressor and others by an activator? We will test this in the context of reduction of errors in transcription control. (3) Are there principles that describe how drugs combine to affect protein dynamics in human cells? We will use a novel dynamic proteomics approach developed in our lab to explore how protein dynamics can be controlled by drug combinations. This research will define principles that unite our understanding of seemingly distinct biological systems, and explain their particular design in terms of systems-level functions. This understanding will help form the basis for a future medicine that rationally controls the state of the cell based on a detailed blueprint of their circuit design, and quantitative principles for the effects of drugs on this circuitry.

Keywords: protein circuits,dynamic proteomics