Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine (CISTEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Argentina,Poland,Serbia,France,France,United States
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 364500.0
EU funding (EUR): 364500.0
Participants: 8
Project status: SIGNED

Many rare diseases cause chronic health problems or are even life-threatening. The impact on the quality of life of affected patients, of whom many are children, is significant. To date, a limited but increasing number of so-called orphan drugs (drugs for rare diseases) are reaching patients. However, the majority of rare diseases are still without any effective treatment. The development of novel human systems for drug discovery therefore represents a major public health priority. Microfluidic technology-based “Organs-on-a-chip” represents a powerful tool for investigating rare disease mechanisms and testing new drug and treatment due to their ability to mimic tailored micro-environment architecture inspired by organ-level functions in vivo. However, due to the variability in rare disease mechanisms from one patient to another, organ on chip technology needs to be more precise and to convey towards personalized medicine. The human-induced pluripotent stem cells (iPSCs) have a strong potential in engineering organ-on-a-chip since they are derived in a patient-matched manner which makes them a superb source to construct human models for personalized drug screening as well as for understanding patient-specific fundamentals of diseases. To provide novel miniaturized platform for investigation of rare diseases able to address the burning issues in precision medicine today, CISTEM will bring together and synergistically several highly promising research directions which are too often investigated separately at the academic level but also at the industrial level. Based on 4 work packages, the CISTEM RISE project will be implemented by exploiting the complementary expertise of its partners and creating synergies between them through the targeted secondments of staff.

Keywords: organ on chip,rare diseases,ipscs,microfluidic,cell differentiation
Star-Planet-Inner Disk Interactions (SPIDI): unveiling the formation and evolution of inner planetary systems (SPIDI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 2362230.0
EU funding (EUR): 2362230.0
Participants: 1
Project status: SIGNED

With more than 2,000 confirmed exoplanets discovered to date, and about 4,000 additional candidates, it is now widely accepted that nearly every star in the Galaxy hosts a planetary system. These systems greatly differs from our Solar System: a vast majority of exoplanets revolves at a distance less than the Earth’s orbit (1 astronomical unit, 1 AU), and many orbit very close to their parent star indeed (<0.1 AU). These inner planets, with an orbital period less than 100 days, are quite diverse, ranging from Earth-like to Jupiter-like. How do they form or migrate close their star is still an open issue. ALMA and VLT/SPHERE recently released spectacular images of circumstellar disks around young stars, which exhibit large-scale structures (>10 AU), including rings, gaps, and spiral arms that presumably are the signposts of planet formation. Yet, as powerful as they are, imaging techniques are yet unable to probe the inner disk region. The goal of the SPIDI project is to investigate the origin and evolution of inner planetary systems. Specifically, we will develop dynamical models of inner planets embedded in the accretion disk of young stars to investigate the physical processes that govern the star-disk-planet interactions from 1 AU down to the stellar surface. From these models, we will then predict the observational signatures of disk-embedded inner planetary systems, and devise and implement observations that will allow us to detect them. This can only be done indirectly through simultaneous time domain photometry, spectroscopy, spectropolarimetry, and interferometry. Combined with current results obtained on larger scales, the SPIDI project will thus yield a synthetic view of nascent planetary systems, down to the inner edge of protoplanetary disks. It will bring clues to the origin of our own inner Solar System, and more generally, address the formation process and ubiquity of inner planetary systems throughout the Galaxy.
Advanced RF Transceivers for 5G base stations based on GaN Technology. (5G_GaN2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Ireland,Italy,Germany,Germany,Germany,Germany,Italy,Slovakia,Sweden,Sweden,France,France,France,Netherlands,Luxembourg
Call: RIA (H2020-ECSEL-2017-2-RIA-two-stage, 2017)
Start date: 2018-06-01
End date: 2022-05-31
Duration (months): 48.0
Total project cost (EUR): 20568990.85
EU funding (EUR): 5988277.67
Participants: 17
Project status: CLOSED

TA new generation of communications infrastructure is currently in development. The fifth generation (5G) communications technologies will provide internet access to a wide range of applications: from billions of low data rate sensors to high resolution video streaming. The 5G network is designed to scale across these different use cases and will use different radio access technologies for each use case. To support very high data rates 5G will use wide bandwidth spectrum allocation at mm-wave frequencies. The offered bandwidth at the mm-wave frequencies (above 24 GHz) is more than 10 times as large as that in the lower bands (sub 6 GHz). However, the move to mm-waves comes at a cost – increased path loss. This makes it extremely challenging to provide coverage at mm-wave frequencies. A partial remedy is to use beamforming to direct the radio energy to a specific user. For some deployment scenarios beamforming is not enough and the output power must also be increased. A major challenge is to bring affordable, high-performance mm-wave active antenna arrays into production. There is currently a market pull for this systems. The main objectives of the “5G_GaN2” proposal are substantial lowering the cost, power consumption and increase the output power of mm-wave active antenna systems. Advanced Gallium Nitride (GaN) technology will be used to get maximum output power and energy efficiency. High-volume and low-cost packaging and integration techniques developed for digital applications (CMOS) will be used. The capabilities of the developed technology will be shown in a set demonstrators. The application driven demonstrators will be used to guide the technology development towards maximum impact and exploitation in the post project phase. The consortium spans the complete value chain: from wafer suppliers, semiconductor fabrication and system integrators. In addition, key universities and research institutes guarantees academic excellence throughout the project.

Keywords: rf cmos,base station,packaging,system in package,power,millimeter,linearity,mmic,modeling,design,ka band,e band,radio
Innovative Tools for Cyber-Physical Energy Systems (InnoCyPES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Austria,Norway,Serbia,France,Netherlands,Netherlands,United Kingdom,Denmark,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 4196311.92
EU funding (EUR): 4196311.92
Participants: 11
Project status: SIGNED

The principal goal of the InnoCyPES ITN is to provide world-leading and transferable scientific training to a new generation of 15 high-achieving early stage researchers (ESRs). In the course of their training, they will study, investigate and improve various facets of digitalized and interconnected energy systems. Supervised by a consortium of prominent and experienced academic institutions, research institutes and industrial partners, they will collaboratively develop a cutting-edge system management platform that covers the entire lifecycle of data for energy system planning, operation and maintenance, based on an understanding of the energy system as a cyber-physical system. The increasing volume, velocity, and variety of data from a massive number of dispersed “Internet of things” sensors in the energy system offers opportunities for improved operational efficiency and reliability – but it also results in threats in the form of computational burden and cyber-attacks. The transformation towards a fully digitalized energy system requires substantial improvements in coordinated design of cyber and physical systems, end-to-end data processing tools, and enabling changes in policy, incentive and regulatory mechanisms. Their absence acts as a barrier for the energy industry in translating the fast-accumulating data into actionable knowledge. The ESR projects will target key bottlenecks for this digital transformation. The tools that will be developed will be released as an open source platform for maximum impact. In InnoCyPES, the ESRs will be enrolled in an intensive doctoral training program that is both intersectoral – involving key stakeholders – and interdisciplinary, including information science, energy systems engineering and social science. Moreover, each ESR has both academic and industrial advisors. It will thus provide ESRs with skills that are in high demand by industry and academia, preparing them for thriving careers in this burgeoning area.

Keywords: digitalization,interconnected energy systems,policy
Algorithms in algebra and topology (GroupsComputability)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Group theory is the study of symmetry in mathematical objects, such as rotations of geometric shapes. Groups help us understand the underlying structure of mathematical objects by revealing their symmetries. To understand groups we need an efficient way to describe them. Some groups admit a finite presentation; a finite set of building blocks, along with a finite collection of rules on when we can substitute one set of blocks for another. These descriptions are convenient. However, results in algebra and logic show that such descriptions are not always suitable to work with, as certain problems (e.g., the word problem, of deciding if two distinct collections of blocks represent the same group element) are incomputable; no computer can be built to always answer this. We can embed incomputable problems from groups into geometry, to show that the homeomorphism problem, of recognising if two geometric shapes are equivalent under smooth deformation, is incomputable in all dimensions above three. Thus we can't computationally classify geometric shapes in higher dimensions; we can't identify the unique distinguishing features of each shape. The study of generic computability (problems which can be computed most of the time) is a useful area in mathematics. Conversely, showing a problem can't be computed most of the time gives rise to applications in cryptography: generically incomputable problems are an excellent tool in the theory behind cryptosystems. This proposal will deal with incomputable and generically incomputable problems. We will investigate certain problems in group theory to determine if they are computable, or generically computable, or neither. We will apply these results to particular classess of higher-dimensional geometric objects, identifying whether certain problems relating to them are computable or not. The project will be carried out at the University of Cambridge, under the supervision of Dr. Henry Wilton.

Keywords: decision problems in group theory,higman embedding theorem
Satellite Technology for Advanced Railway Signalling (STARS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Spain,Germany,Italy,Germany,Germany,Spain,Italy,Italy,Switzerland,Belgium,Belgium,Sweden,France,France,France,Czechia,Czechia
Call: EGNSS applications (H2020-Galileo-2015-1, 2015)
Start date: 2016-02-01
End date: 2018-11-30
Duration (months): 34.0
Total project cost (EUR): 4458831.5
EU funding (EUR): 3255484.64
Participants: 23
Project status: CLOSED

The STARS project paves the way for the future EGNSS deployment in safety relevant railway applications. By evolving the highly developed and deployed ERTMS standard through the implementation of the satellite positioning functionality, it will be possible to reduce the cost of the future railway signalling systems, especially for lines with lower traffic density. The project deals with three main topics: 1) The elaboration of reference data and characterisation of the railway environment through a measurement campaign; 2) The assessment of the EGNSS performances achievable in the railway environment with the determination of the applicable requirements for the positioning system as well as the necessary evolutions of EGNSS services and ERTMS/ETCS functions and 3) Quantification of the economic benefits and specifying the possible implementation roadmap when applying the EGNSS on railways. The project is strongly linked with other initiatives and actions on the same topic in Europe. In order to feed directly into the standardization work of ERTMS, the project partners will cooperate closely with UNISIG. Moreover, the project will actively interact with NGTC (EU funded FP7) and the results will be directly implemented by SHIFT2RAIL, providing the practical demonstrators for different categories of railway tracks. The approach developed in STARS is also taking the profit of the strong know-how inherited from civil aviation, making this project as completely integrated and consistent in overall activities in Europe and worldwide, leading to the effective deployment of the satellite technologies in advanced railway signalling systems.

Keywords: gnss,ertms,etcs,railways,signaling,gnss receivers,train positioning,safety
Adaptive plasticity meets unpredictability: how do organisms cope with changing environmental variability? (THERMOPLAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-07-05
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Natural populations are continually exposed to environmental change and respond in the short-term via plastic mechanisms and over longer time periods by genetic adaptation. Both plastic and genetic responses to changes in the mean environment are well understood. However, less is known about the responses to changes in the variability and stochasticity of environmental parameters. Optimal phenotypes are known to depend on levels of environmental variability. This means that if levels of variability are predictable, plastic and/or genetic adaptations can be expected. However, both the levels of variability as well as their predictability may change over time and space. Understanding adaptive responses to such changes in the pattern of environmental variability (rather than mean values) represents a major frontier in ecology and evolution and is the main focus of this proposal.

Keywords: plasticity,physiology,development,thermal tolerance,environmental change
Borylated Conjugated Materials (BORCOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Recent work at the University of Manchester has developed an efficient synthetic method for transition metal free electrophilic borylation of aromatics and heteroaromatics. This approach has recently been extended to the fusion of conjugated materials containing the acceptor moiety benzothiadiazole – a group that is ubiquitous in materials for organic electronics. This functionalization leads to a significant increase in the electron affinity of the materials and a considerable reduction in the band gap, consistent with near-IR emission in organic light emitting diodes (OLEDs), ambipolar organic field effect transistor (OFET) mobility, improved n-type stability and effective light harvesting in organic photovoltaic cells (OPVs). The BORCOM project will use this methodology to deliver novel molecules and polymers that exhibit high electron affinities and small band gaps by functionalization of azole or azine containing acceptors in the conjugated backbone. The performance of the new materials as n-type semiconductors in OFETs, light harvesting and electron acceptors in OPVs and dopants/emitters in OLEDs will be evaluated.

Keywords: organic semiconductors,organic electronics
Francophone African and Caribbean Theaters (FACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The cultural and artistic expressions of Black minorities are still unknown, devalued, and understudied in France today where exclusion and discrimination keep growing. Therefore it is urgent to analyze and recognize the work of African and Caribbean dramatists who embody the diversity and multiculturalism of our global contemporary world. The goal of FACT (Francophone African & Caribbean Theaters) is to revisit the history of Francophone Black theaters born out of the brutal encounter of Europe, Africa and the Americas, and to evaluate the effects of colonialism and postcolonialism on contemporary France. This colonial legacy is still denied today although being an integral part of the French national history. As a specialist of Caribbean theater, I will join the Theater studies Department at the University Sorbonne Nouvelle to collaborate with Professor Chalaye, specialist of African drama, to examine plays written by dramatists from Africa and the Caribbean from the 1960s to date. We intend to show that migrations that followed decolonization have transformed, nourished and enriched the French nation. We also want to challenge not only stereotypes and prejudices against Black minorities, but also the conception of a homogeneous unique French identity. FACT will contribute to make Francophone African and Caribbean drama more visible in the field by creating a database of texts and audio/videorecordings and by developing a postcolonial analysis of the materials. The outcome of FACT will create awareness among the general public of the reality of a multi-racial and multi-cultural nation born of a shared colonial history with the ultimate goal to encourage French and European citizens to lose their fears of the “Other,” to be opened to the difference, and to welcome and celebrate the diversity of Europe.

Keywords: theater caribbean african francophone colonisliam postcolonialim
Thermal Evaluation of specific drug delivery with Molecularly imprinted nanoParticles developed against Estrogen Receptor (TEMPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-04-22
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Breast cancer is the most commonly occurring cancer in women with over two million new cases reported in 2018. It is a genetically diverse disease with each type requiring different treatment. In developing countries, the highest amount of female cancer deaths are attributed to breast cancer with substantially lower survival rates compared to the western world. Therefore, the aim of this proposal is to develop polymeric drug nanocarriers that can improve drug efficacy, and thereby have potential to make cancer treatment available to all layers of the population including those living in deprived areas. We will develop high affinity nanoparticles that can selectively bind to certain receptors on the surface of cancer cells. When attached, the nanocarriers will release their cargo (drug compounds) specifically to the tumour and thereby improve drug efficacy and subsequently patient outcome. Furthermore, it will reduce adverse effects of common anti-cancer drugs including nausea, fatigue, hepatitis and high vulnerability to endometrial cancer. The drug delivery is usually monitored with optical techniques but the novelty of this project is to use thermal analysis, which is label-free and simple to use. The polymeric nanocarriers are highly versatile and by changing the composition, we can tailor this platform to other drug compounds or other cancer types. In addition, it has high potential as a diagnostic tool in high-throughput drug testing, customization of cellular therapy, and combating bacterial infections. This project could bring tremendous benefits in cancer treatment particularly in developing countries such as India due to its low-cost and simplicity.

Keywords: targeted drug delivery,biomimetic sensors,thermal analysis