Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Individualized CARE for Older Persons with Complex Chronic Conditions at home and in nursing homes (I-CARE4OLD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Israel,Belgium,Belgium,Poland,Sweden,Finland,Czechia,Netherlands,United States,Canada
Call: Use of Real-World Data to advance research on the management of complex chronic conditions (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 6492416.59
EU funding (EUR): 5832536.25
Participants: 14
Project status: SIGNED

BACKGROUND Optimal care for older patients with complex chronic conditions (CCC) is challenging. Not only do older patients with CCC present with multiple conditions and functional impairments, these often interact with each other, as well as with their treatments. Patients with CCC are concentrated in home care and nursing home settings. Professionals working in these settings often lack appropriate decision support that mirrors the medical and functional complexity of these persons. AIM To improve prognoses and estimation of treatment impact for older care recipients with CCC in home care and nursing homes settings, and develop, validate, and test next generation individualised decision support. IMPACT Better informed decision making for clinical management of older care recipients with CCC in home care and nursing homes, through (1) high quality internationally validated predictive algorithms on disease trajectories and treatment outcomes; (2) a multi-nationally tested e-platform for health professionals to receive predictive scenarios on course and treatment outcomes of newly assessed care recipients at point of care; and (3) dissemination among health professionals working in nursing homes and home care. APPROACH We collated longitudinal data from 52 million older recipients of home care and nursing home care from eight countries including (1) highly reliable, valid and harmonised comprehensive assessments of functional capacities, diseases, and treatments, linked with (2) administrative repositories on mortality and care use. We develop and validate decision support algorithms using a variety of techniques including machine learning to better predict (i) outcomes (eg death, acute admissions, quality of life) and the modifying impact of (ii) pharmacological and (iii) non-pharmacological treatments. We co-create decision support output with health professionals and patients and pilot it's applicability at point of care with an e-platform.

Keywords: geriatrics,complex chronic conditions,home care recipients,nursing homes,decision support,algorithms,big data,machine learning,prognosis,medications,treatment impact,safety
Quantum Tensor Networks and Entanglement (QUTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1927500.0
EU funding (EUR): 1927500.0
Participants: 1
Project status: CLOSED

One of the major challenges in theoretical physics is the development of systematic methods for describing and simulating quantum many body systems with strong interactions. Given the huge experimental progress and technological potential in manipulating strongly correlated atoms and electrons, there is a pressing need for such a better theory. The study of quantum entanglement holds the promise of being a game changer for this question. By mapping out the entanglement structure of the low-energy wavefunctions of quantum spin systems on the lattice, the prototypical example of strongly correlated systems, we have found that the associated wavefunctions can be very well modeled by a novel class of variational wavefunctions, called tensor network states. Tensor networks are changing the ways in which strongly correlated systems can be simulated, classified and understood: as opposed to the usual many body methods, these tensor networks are generic and describe non-perturbative effects in a very natural way. The goal of this proposal is to advance the scope and use of tensor networks in several directions, both from the numerical and theoretical point of view. We plan to study the differential geometric character of the manifold of tensor network states and the associated nonlinear differential equations of motion on it, develop post tensor network methods in the form of effective theories on top of the tensor network vacuum, study tensor networks in the context of lattice gauge theories and topologically ordered systems, and investigate the novel insights that tensor networks are providing to the renormalization group and the holographic principle. Colloquially, we believe that tensor networks and the theory of entanglement provide a basic new vocabulary for describing strongly correlated quantum systems, and the main goal of this proposal is to develop the syntax and semantics of that new language.

Keywords: entanglement,real space renormalization group methods,mathematical physics,computational physics
Rapid diagnostic for bacterial SEPSIS and AMR urgently needed for ICU patients in COVID-19-like epidemics (RAPID-SEP-AST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 3570625.0
EU funding (EUR): 2499437.5
Participants: 1
Project status: CLOSED

SEPSIS is a life-threatening reaction to infection with 48.9 million cases and 11 million deaths worldwide, 700.000 of those in the EU yearly. In epidemic-like situations such as COVID-19, SEPSIS is prevalent in >60% of the admitted patients and all non-survivors had SEPSIS. SEPSIS patients require immediate antibiotic therapy to prevent disease progression and reduce mortality. Therefore, clinicians administer empirically broad-spectrum antibiotics, which save lives but also lead to inappropriate treatments in up to 40% of cases. To identify the best antibiotic and dosage for each patient, clinicians in Acute Care and ICUs need to run diagnostics to identify both the pathogen causing the infection but test several antibiotics to find the specifically treating the infection. Antibiotic susceptibility testing takes too long to be useful in SEPSIS cases. Resistell, a Deep-Tech SME, has a breakthrough AST technology delivers AST diagnostic results in less than 2h instead of the current 24-48h. Clinicians around the world using RAPID-SEP-AST will for the first time select personalised antibiotic therapies to SEPSIS patients in the same day, increasing the success rate of treatment and reducing hospitalisation time and costs. This EIC project will accelerate RAPID-SEP-AST industrialisation, finalise CE-IVD approval and support market-critical proof of efficiency in a multicentre performance evaluation study at KOLs. RAPID-SEP-AST will allow rapid Resistell scale-up first in Europe using its strong network of EU distributors and then globally through leading global distributors. Resistell’s is a Women-Led Company (Danuta Cichocka CEO) with a strong cross-functional team of engineers, microbiologists, data scientists and serial entrepreneurs, supported by experienced Board of Directors and Scientific Advisors.

Keywords: antimicrobial susceptibility testing,sepsis,covid 19,secondary infection,septic shock
Role of Apolipoproteins L in immunity and disease (APOLs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-06-30
Duration (months): 70.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: CLOSED

Work conducted in my laboratory on the trypanosome killing factor of human serum led to the identification of the primate-specific Apolipoprotein L1 (APOL1) as a novel pore-forming protein with striking similarities with proteins of the apoptotic BCL2 family. APOL1 belongs to a family of proteins induced under inflammatory conditions in myeloid and endothelial cells. APOL1 is efficiently neutralized by the SRA protein of Trypanosoma rhodesiense, accounting for the ability of this trypanosome subspecies to infect humans and cause sleeping sickness. We found that natural APOL1 variants escaping SRA neutralization and therefore conferring human resistance to T. rhodesiense are associated with chronic kidney disease. Moreover, transgenic mice expressing these APOL1 variants exhibit an obese phenotype. Our unpublished results also indicate that APOLs control the lifespan of dendritic cells and podocytes activated by viral stimuli. Therefore, we propose that the pathology of APOL variants is due to their deregulated activity on the control of the cellular lifespan in myeloid/endothelial cells activated by pathogen detection. This project aims at characterizing (i) the molecular mechanism by which APOLs control the lifespan of activated dendritic cells and podocytes, which has direct impact on innate immunity and inflammation, and (ii) the mechanism by which APOL1 variants cause pathology. In addition, we plan to detail the physiological function of APOLs by studying the phenotype of transgenic mice either expressing human APOL1 (wild-type and variants) or devoid of APOL genes, which we have recently generated. Finally, we propose to exploit the extraordinary potential of trypanosomes for antigenic variation in order to produce SRA variants able to neutralize the pathogenic APOL1 variants. Preliminary experiments suggest that in podocytes SRA antagonizes APOL1 induction by viral stimulus and subsequent cell death, opening new perspectives to treat kidney disease.

Keywords: apolipoproteins l,kidney disease,innate immunity,trypanosome
Online Privacy Enforcement, Rights Assurance and Optimization (OPERANDO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Israel,Greece,Romania,United Kingdom,United Kingdom
Call: Privacy (H2020-DS-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 4455811.25
EU funding (EUR): 3746037.0
Participants: 10
Project status: CLOSED

The goal of the OPERANDO project is to specify, implement, field-test, validate and exploit an innovative privacy enforcement platform that will enable the Privacy as a Service (PaS) business paradigm and the market for online privacy services. The OPERANDO project will integrate and extend the state of the art to create a platform that will used by independent Privacy Service Providers (PSPs) to provide comprehensive user privacy enforcement in the form of a dedicated online service, called “Privacy Authority”. The OPERANDO platform will support flexible and viable business models, including targeting of individual market segments such as public administration, social networks and Internet of Things. A key aspect addressed by OPERANDO is the need to simplify privacy for end users (data subjects). OPERANDO will support a simple Privacy Dashboard allowing users to specify their preferences. These will be automatically compared with Online Service Provider (OSP) privacy policies and translated into personal data access control decisions by the PSP. OPERANDO will also address OSP requirements for simplified privacy compliance checking and auditing, to verify that they will meet user expectations or to satisfy privacy regulators. The technology will be trialled in the health care and public administration sectors. The OPERANDO consortium thereby aims to contribute to the entire ecosystem of online privacy stakeholders: Users, PSPs, Online Service Providers and Regulators. Federation of Privacy Authorities will be supported to increase value of the services and their uptake. The OPERANDO platform will be positioned for endorsement by European governments and standardization bodies. To increase transparency of the privacy services and dissemination of results, OPERANDO outcomes will be implemented in Open Source, and will be made available to the community for evolution and value-adding beyond the scope of the project.

Keywords: privacy service provider,privacy authority,product management,legally justified privacy by design,european privacy standards,citizen empowerment
Global Platform for Indoor Location Services (GlobILS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Finland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 3160000.0
EU funding (EUR): 2212000.0
Participants: 1
Project status: CLOSED

Today more than 4 billion people live in urban environments, spending over 90% of their time indoors. Urban Mobility will be one of the toughest challenges for cities around the globe. Taking into consideration 12,6% increase in the global smartphone use adoption this year alone, indoor positioning market is on track to grow 36% CAGR to over 4B€ in 2020. IndoorAtlas – Finland-based technology SME – is the only global provider delivering an indoor location Platform-as-a-Service (PaaS). IndoorAtlas cloud platform provides an interface for application developers to create venues, manage data and build their location-based services within their mobile application. The platform seamlessly supports both Android and iOS devices ensuring that developers can build a wide range of application features that support navigation, search and discovery, and proximity advertising. The innovative platform leverages geomagnetic indoor positioning technology and utilises the digital compass present in every smartphone. It enables currently over 25,000 registered developers to create highly scalable mobile applications that utilise indoor positioning. The key ambition of this project is to scale-up and expand IndoorAtlas concept into new geographical and sectoral markets by reaching to potential customers in new industrial verticals, educating and developing the market in the process, as well as enhancing global support and customer success.

Keywords: indoor location services
Cancer-Cell Specific Organometallic Ru(II) Complexes as Photosensitizers in Photodynamic Therapy (OrganometRuPDT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2021-07-15
Duration (months): 14.0
Total project cost (EUR): 107746.24
EU funding (EUR): 107746.24
Participants: 1
Project status: CLOSED

In this project, I plan to use cyclometalated Ru(II) polypyridyl complexes as novel photosensitizers (PSs) in photodynamic therapy (PDT) to fight cancer. Such compounds are easier to synthesise than the well-known porphyrins and have a higher lipophilicity (to better cross the cell membrane) and a bathochromic shift of the absorption (to irradiate at low energies) than the usual Ru(II) polypyridyl complexes. Furthermore, I plan to couple maleimide moieties to these complexes to directly bind cysteine-containing biomolecules (i.e. HSA) and therefore, overcome the selectivity issues observed for the typical PSs. The use of bisbenzimidazoles as ancillary ligands will allow to tune the properties of the complexes in view of having the most red-shifted absorption. Computational chemistry will be first used to design the complexes, and after the synthesis and complete characterization, biological experiments will be performed to evaluate their potential as PSs. A secondment under the supervision of Prof. Clotilde Policar will allow localizing the compounds prepared by the use of a synchrotron-based imaging technique (X-ray fluorescence) as well as single cell ICP-MS, which will help to detect the metal inside the cell and figure out the biodistribution of the complexes. The multidisciplinary scope of this work along with their innovative aspects to selectively cause death of cancerous cells, make it a ground-breaking proposal. In addition, working in one of the best universities of the world, under the supervision of Dr. Gilles Gasser and Prof. Clotilde Policar will promote my scientific career.

Keywords: photodynamic therapy pdt,medicinal inorganic chemistry,bioorganometallic chemistry,ruthenium,cancer
Unveiling Stomata 24/7: Using Stable Isotopes and COS to quantify diurnal and nocturnal carbon and water vegetation-atmosphere Fluxes under future climate scenarios (USIFlux)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Rising atmospheric CO2 concentration, increasing temperature and altered precipitation patterns dramatically impact the terrestrial biosphere with important consequences for all biogeochemical cycles. Predictions of carbon (C) and water exchange between vegetation and the atmosphere require detailed mechanistic understanding of how plants control water loss and C gain through their stomatal pores. Currently, global circulation models incorporate formulations of stomatal conductance (gs) based on stomatal optimisation theory. However, these models ignore gs regulation: (1) during night time, despite clear evidence for significant nocturnal transpiration, (2) in non-vascular plants and (3) during leaf development and senescence. To reduce the uncertainty associated with current C and water fluxes in models, we need to incorporate robust predictions of gs in response to novel environmental conditions (higher temperature, decreased water availability and elevated CO2). To fill these gaps, USIFlux, will develop a novel tracing technique to measure gs during the dark, when fluxes are an order of magnitude smaller than during the day. To do so, we will combine measurements of COS (carbonyl sulphide) uptake with CO18O fluxes and changes in the oxygen isotope composition (δ18O) of water in leaves. We will relate the response of gs at night to changes in gs during the day and in response to drought and elevated CO2. These measurements will be coupled to an experiment to investigate stomatal regulation during leaf ontogeny and in different life forms. Here, we will challenge the stomatal optimisation theory in life forms lacking active stomatal control (mosses and brackens) and during leaf development, when leaf construction costs constrain the optimisation of C gain. Empirical formulations arising from these experiments will be incorporated into large-scale soil-vegetation-atmosphere transfer models to explore their impact at larger scales.

Keywords: stomatal conductance,photosynthesis,oxygen isotopes,drought
Fiction, Imagination, and Early Cinema (FIEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

The project investigates two closely interrelated issues: what is the role of imagination in early cinema and what does it mean for a representational work to be fictional? Specifically, it asks what the criteria are according to which we categorize texts as fictional and what counts as proof for reconstructing the experience of historical spectatorship. The project innovatively proposes that the period between 1880 and 1915 provides a unique opportunity for construing how a representational medium becames employed in the production of fictions and the crucial role the discourse on imaginary engagement plays in this process. In other words, the project asks why we engage some films as fictions and other as documentaries despite the fact that they are both based on actuality material – photographs. For instance, why, when watching Méliès’ 1898 The Astronomer’s Dream or the Man in the Moon, do we nowadays regularly say that we are watching an astronomer whose gazing at the moon turns into a series of fantastical mishaps? Why do we engage such a film as a fiction rather than as a documentary of actors performing in front of painted sets? Especially if during the early era, such films were regularly seen as instances of “canned theater”, i.e. as documentaries of theatrical performances. Methodologically, the project is highly unique in its twofold approach. On the one hand, the proposal draws on analytic philosophy to articulate the key concepts informing the inquiry – fiction and imagination. Fiction, crucially, is construed as “any mandated imagining/make-believe" following the work of Kendall Walton. On the other, the project applies the new film history method to late 19th and early 20th century sources such as trade press, catalogues, lectures, and more general discourse on cinema and adjacent cultural practices to determine what place the notions of fiction and imagination played in the production, promotion, exhibition, and reception of early cinema.