Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PEMFC based on platinum Group metAl free StrUctured cathodeS (PEGASUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Germany,Spain,Belgium,France,Denmark
Call: Towards next generation of PEMFC: Non-PGM catalysts (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-02-01
End date: 2021-06-30
Duration (months): 41.0
Total project cost (EUR): 2829016.88
EU funding (EUR): 2829016.88
Participants: 9
Project status: CLOSED

PEMFC is the fuel cell predilection technology for automotive applications with a large deployment horizon by 2025-30. However, the increasing use of fuel cell electrical vehicles is expected to lead to a quickly growing demand for Platinum Group Metals. PGM production is not only itself related to negative environmental impacts but also raises questions of long-term availability due to the limitation of reserves and Europe’s economic dependence on the countries of the materials’ origin. Hence, it is of strategic importance that the transition to PGM-free catalysts is made as quickly as possible to ensure Europe's competitive position and to reduce market pressure on the use of scarce noble metals. In that perspective, PEGASUS is exploring the removal of Pt and other critical raw materials and their replacement by non-critical elements enabling efficient and stable electro-catalysis for performing and durable PEMFCs. The overall aim of the project is to bring up the experimental proof of concept for novel catalysts with five underlying objectives supporting a full validation at single cell scale with a focus on the cathode side: 1) High performance, 2) durable and 3) low cost MEA using non-PGM catalysts-based cathode; 4) Robust test protocols for catalysts screening and 5) Understanding of degradation and prevention & mitigation strategies through a MEA design-driven approach. PEGASUS will benchmark (Metal-Nitrogen-Carbon) materials with variants of Carbon supports and Catalyst Layer designs in order to reach the best compromises between chemical activities and mass/charge transfer with the support of intensive experimentation and modelling. Two generations of non-CRM catalysts will be proposed. GEN1 will implement metals {Fe, Mn or Cu} with Nitrogen onto (1D, 2D and 3D) structured carbon support (single structuration). GEN2 will investigate the enhancement of dual-structuration (1D+3D and 2D+3D) on catalyst stability, reactant availability and water management.

Keywords: pgm free catalyst,fuel cell electric vehicles,european competitiveness,energy self sufficiency
ENERGY EFFICIENCY PROJECT DEVELOPMENT FOR SOUTH ATTICA (PRODESA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Belgium,Greece,Belgium,Greece,Greece,Greece,Greece
Call: Project Development Assistance (H2020-EE-2016-CSA, 2016)
Start date: 2017-05-01
End date: 2022-01-31
Duration (months): 57.0
Total project cost (EUR): 1058760.0
EU funding (EUR): 1058760.0
Participants: 13
Project status: CLOSED

Seven major municipalities in the Athens Metropolitan Area join efforts to launch showcase energy efficiency and renewable energy projects, utilizing innovative financial tools and attracting private investments. The projects comprise energy efficiency interventions in 116 municipal buildings, integration of a total 3.2 MW of photovoltaics on the roofs of these buildings and re-lamping for the municipal lighting. Total energy savings is 45.6 GWh/y and renewable electricity production is 4.8 GWh/y. Total cost for interventions is 20.24 M€ and the PRODESA cost is 1.06 M€. To achieve its objectives, the project shall focus on optimal bundling of the fragmented municipal projects to achieve considerable size, reasonable payback time and risk diversification. Bundling is also expected to lower processing costs. Pooling of resources is used to optimize financial results for all parties and to ensure high participation of ESCOs in the tenders. The newly introduced National Revolving Fund for Energy Efficiency and the Utility ESCO Fund will be part of the pool. Pooling will facilitate the exploitation of innovative financing schemes. Crowdfunding has been recently introduced in the Greek legislation and this tool will be carefully studied and applied. PRODESA is the first of its kind effort in Greece and aims to significantly contribute to the Energy Performance Contracting take-off. For this reason the project consortium has pooled together Key Actors such as the National Center for energy efficiency, the European Crowdfunding Network and entities with technical, financial and legal expertise. Being a showcase project, it emphasizes on capacity building, replicability, dissemination and exploitation of results. Two replicator municipalities are directly involved in the project and a network of at least 30 replicators will be initiated with the help of the Central Union of Municipalities of Greece.
Photonic Integrated Circuits Accessible to Everyone (PICs4All)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Spain,Italy,Poland,Greece,France,France,Netherlands,Netherlands,Denmark,United Kingdom
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-06-30
Duration (months): 42.0
Total project cost (EUR): 1051895.0
EU funding (EUR): 1051895.0
Participants: 11
Project status: CLOSED

The prime objective of PICs4All is to increase the impact of photonics and enable access to the advanced photonic integrated circuit (PIC) technologies for academia, research institutes, SMEs and larger companies. This will be achieved by establishing a European network of Application Support Centres (ASCs) in the field of PIC technology. The main task of the ASCs is to lower the barrier to Researchers and SMEs for applying advanced PICs, and thus to increase the awareness of the existence of the worldwide unique facility provided by JePPIX (InP and TriPleX PIC design, manufacturing, testing and packaging). The main objectives of PICs4All are: active scouting opportunities for the use of PICs; promoting the use of the PIC platforms; strengthening Europe’s industrial lead in the business of integrated photonics; bringing together academia to explore photonics and promote its critical importance. These will be achieved by: reaching out to potential users that are not yet aware of the benefits of PIC’s; organizing PIC design courses, workshops; connecting users to optical chip designers; assisting access to Multi-Project Wafer runs for PIC fabrication; actual supporting in layout design and testing of prototype PICs. All the activities are advocated by publicity e.g. newsletters, application notes and participation in conferences and exhibitions. PICs4All ASCs will actively support users in taking full advantage of the PIC-technology and its deployment in existing and new applications. For this reason it combines the two targets of an EC supported CSA, i.e. enabling the access to advanced design, fabrication and characterisation facilities, and stimulating the innovation potential of users, esp. SMEs, by supplying hands-on support in developing their business cases. All this is achieved by connecting existing PIC-development infrastructure throughout Europe and by lowering the risk at the investment stage in PIC development by enabling access to low-cost prototyping.

Keywords: photonics,application specific photonic integrated circuits,application support centres,technology platforms for photonic ics,innovation,valorization,scouting,collaboration
Automated diagnostic platform, data management system and innovative communication tool, for improving the impact of malaria vector control interventions (DMC-MALVEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ethiopia,Germany,Italy,Greece,Zambia,Switzerland,Greece,United Kingdom,Cameroon,Luxembourg
Call: International partnership building in low and middle income countries (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2020-05-31
Duration (months): 52.0
Total project cost (EUR): 3167376.25
EU funding (EUR): 2768001.25
Participants: 10
Project status: CLOSED

Malaria is a life-threatening disease causing more than 500,000 deaths every year in sub-Saharan Africa. Prevention of the disease is best achieved by vector control which relies on the use of insecticides. Monitoring mosquito vector populations is an integral component of control programmes and a prerequisite for effective interventions. Several individual methods are used for this task, However, there are obstacles to their uptake, as well as challenges in organizing, interpreting and communicating vector control data. We will develop a fully integrated and automated multiplex vector-diagnostic platform (LabDisk) for monitoring the species ID, the infection status of mosquitoes and the insecticide resistance profile of malaria vector populations. The system will provide sample-to-answer determinations, and it will perform genotyping at substantially lower cost, compared to the assays that are currently used in Africa. The LabDisk will be interfaced with a Disease Data Management System (DDMS), custom made data management software which will collect data from routine entomological monitoring activities, store, and make available stratified information based on “user queries” in a standardized way. The “GAME”, a modern ICT platform that employs interactive ways of communicating guidelines and exemplifying good practices of successful use of interventions in the health sector will be also employed, to teach operational end users the use of data to make informed decisions. The integrated system (LabDisk, DDMS & Game) will be implemented in four sub-Saharan African countries, highly representative of malaria settings and vector control problems, to support informed decision-making about vector control and disease management. It will cover the urgent needs of an existing “market” and will provide solution to end users, to address a most important societal challenge in Africa, the control of malaria. The system has a vast expansion potential in other applications.

Keywords: malaria,diagnostic,molecular diagnostic,mosquito,insecticide resistance,database,data management,game,vector,bednet,integrated management
Self-Adjusting Networks (AdjustNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria,Germany,Israel
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1670822.99
EU funding (EUR): 1115260.49
Participants: 3
Project status: SIGNED

Communication networks have become a critical infrastructure of our digital society. However, with the explosive growth of data-centric applications and the resulting increasing workloads headed for the world’s datacenter networks, today’s static and demand-oblivious network architectures are reaching their capacity limits. The AdjustNet project proposes a radically different perspective, envisioning demand-aware networks which can dynamically adapt their topology to the workload they currently serve. Such self-adjusting networks hence allow to exploit structure in the demand, and thereby reach higher levels of efficiency and performance. The vision of AdjustNet is timely and enabled by recent innovations in optical technologies which allow to flexibly reconfigure the physical network topology. The goal of AdjustNet is to lay the theoretical foundations for self-adjusting networks. We will identify metrics that serve as yardstick of what can and cannot be achieved in a self-adjusting network for a given demand, devise algorithms for online adaption, and validate our framework through case studies. Our novel methodology is motivated by an intriguing connection of self-adjusting networks to known datastructures and to information theory. AdjustNet comes with significant challenges since, similar to self-driving cars, self-adjusting networks require human network operators to give away control, and since more autonomous network operations may lead to instabilities. AdjustNet will overcome these risks and achieve its objectives by pursuing a rigorous approach, devising a theoretical well-founded framework for self-adjusting networks which come with provable guarantees and incorporate self–protection mechanisms. The PI is well-equipped for this project and recently obtained first promising results. As the community is currently re-architecting communication networks, there is a unique opportunity to bridge the gap between theory and practice, and have impact.

Keywords: communication networks,network algorithms,routing,online algorithms,datacenter networks,optical networks,information theory,self adjusting datastructures
Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens (BROADimmune)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 1867500.0
EU funding (EUR): 1867500.0
Participants: 1
Project status: CLOSED

The overall goal of this project is to understand the molecular mechanisms that lead to the generation of potent and broadly neutralizing antibodies against medically relevant pathogens, and to identify the factors that limit their production in response to infection or vaccination with current vaccines. We will use high-throughput cellular screens to isolate from immune donors clonally related antibodies to different sites of influenza hemagglutinin, which will be fully characterized and sequenced in order to reconstruct their developmental pathways. Using this approach, we will ask fundamental questions with regards to the role of somatic mutations in affinity maturation and intraclonal diversification, which in some cases may lead to the generation of autoantibodies. We will combine crystallography and long time-scale molecular dynamics simulation to understand how mutations can increase affinity and broaden antibody specificity. By mapping the B and T cell response to all sites and conformations of influenza hemagglutinin, we will uncover the factors, such as insufficient T cell help or the instability of the pre-fusion hemagglutinin, that may limit the generation of broadly neutralizing antibodies. We will also perform a broad analysis of the antibody response to erythrocytes infected by P. falciparum to identify conserved epitopes on the parasite and to unravel the role of an enigmatic V gene that appears to be involved in response to blood-stage parasites. The hypotheses tested are strongly supported by preliminary observations from our own laboratory. While these studies will contribute to our understanding of B cell biology, the results obtained will also have translational implications for the development of potent and broad-spectrum antibodies, for the definition of correlates of protection, and for improving vaccine design.

Keywords: broadly neutralizing antibodies,influenza,malaria,b cells,somatic mutations,affinity maturation,vaccines,t cell help,human genetics
Validation of blood-brain-barrier permeability as a glioma biomarker by means of the radiotracer 99mTc-tetrofosmin and single-photon emission computer tomography (GLIOMARK)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany,Greece
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2021-12-31
Duration (months): 78.0
Total project cost (EUR): 4705344.0
EU funding (EUR): 4705344.0
Participants: 2
Project status: CLOSED

Objective of GLIOMARK is to clinically validate the permeability of the blood brain barrier (BBB) as an in vivo biomarker for the diagnosis and grading of gliomas. This will be accomplished by means of the radiotracer 99mTc-tetrofosmin (TTF) and the imaging technique Single-Photon Emission Computer To-mography (SPECT). The outcome of GLIOMARK is GlioTect, a diagnostic kit containing handling/diagnostic instructions and tetrofosmin. The latter has to be reconstituted with 99mTc pertechnetate to yield TTF, which will be used in combination with SPECT. Often computer tomography or magnetic resonance imaging are unable to detect low-grade gliomas or distinguish glioma from other diseases. Hence, brain biopsies are necessary for confirmation of diagnosis and grading of gliomas. GlioTect with TTF/SPECT enables reliable, fast differential diagnosis and grading of gliomas as non-invasive method. This has an immediate impact on the type and aggressiveness of subsequent therapies. Gliomas are recognized as a rare tumor disease with poor prognosis and orphan diagnostic designation for GlioTect will guarantee 10 years of market exclusivity upon approval. ProActina, a Greek chemical-speciality SME having identified this innovative niche market opportunity could become global market leader in glioma diagnostics. Development is at TLR level 6-7 and will be lifted to 9. Expected market application is the sale of GlioTect for preparation of TTF for use with SPECT. End users are hospitals that use the kit to reliably diagnose or exclude gliomas without the need for expensive equipment. Taken together, the aggregated unique selling point of SPECT in combination with TTF (generated by means of GlioTect) is the first ever and only glioma diagnostic, which assesses a clinically validated glioma biomarker, has high reliability, reproducibility, sensitivity, as well as specificity, which is used to replace an invasive method, is safe, well tolerated, widely available and more affordable

Keywords: glioma diagnostic,clinical validation study
Traditional tomato varieties and cultural practices: a case for agricultural diversification with impact on food security and health of European population (TRADITOM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Israel,Spain,Germany,Italy,Germany,Spain,Greece,Greece,France,Netherlands,United Kingdom
Call: Traditional resources for agricultural diversity and the food chain (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2018-08-31
Duration (months): 42.0
Total project cost (EUR): 4372015.25
EU funding (EUR): 4372015.25
Participants: 16
Project status: CLOSED

Tomato is the second most consumed vegetable in the EU and a major dietary source of many nutrients, vitamins and antioxidants. Consumers complaints about the loss of flavour in modern tomatoes, provide an opportunity for the valorisation of traditional tomato varieties, in order to protect them from genetic erosion and the replacement by higher-yielding, pest resistant modern cultivars. Genetic, epigenetic and phenotypic variability and knowledge from farms and in public repositories, will be concentrated in a TRADITOM database and seed repository (O1). The available genetic and phenotypic variability present in TRADITOM varieties, and the genetic and epigenetic differences from modern cultivars will be assessed (O2). For varieties whose cultivation is not sustainable due to unacceptably low yield and/or pathogen resistance, novel F1 hybrids will be generated, retaining the quality characteristics of traditional varieties and incorporating yield and disease resistance traits (O3) Finally, traditional varieties and the impact of traditional cultivation methods will be valorised through a thorough characterization of their composition in term of flavour- and health-related compounds, the identification of consumer preferences, the evaluation of socio-economic factors limiting their market diffusion, and the protection of the most significant case studies through PDO or PGI denominations (O4). TRADITOM is a multidisciplinary translational, multi-actor research project bringing together scientists working in academia, local farmers communities, consumer experts and small seed companies that have preserved the local germplasm, in order to bring to fruition and apply to traditional tomato varieties the enormous knowledge generated on tomato genetics, genomics and metabolomics. This will help the conservation of traditional tomato varieties and enhance the competitive advantage of rural communities based on their production.

Keywords: traditional tomato varieties,consumer preferences,flavour,aroma,shelf life,farmers,health and nutritional content of fruit,metabolomics,genomics