Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First-in-class TrkB modulator to treat cognitive and negative symptoms in Schizophrenia patients (ReMind)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Pangea Bio is a UK-based biotech SME managed by drug development and neurosciences experts with the mission of developing transformative medicines for neurological and neuropsychiatric disorders. Our drug discovery platform identifies promising nature-inspired molecules to treat central nervous system disorders. Pangea’s lead compound is OT-003, a breakthrough first-in-class TrkB modulator capable of effectively treating cognitive impairment and negative symptoms in neurological and neuropsychiatric disorders, with schizophrenia as the lead indication. By doing so, OT-003 provides a disruptive approach to address a clear unmet need in schizophrenia patients, where only positive symptoms are treated by the current standard of care. Pangea Bio is initiating a First-in-Human Clinical trial with OT-003. To provide schizophrenia patients with a new, safe, and effective treatment option that can significantly improve their quality of life, Pangea Bio is seeking EIC funding to accelerate OT-003’s development through Phase 1a and Phase 1b studies with schizophrenia patients. This is a major inflection point that would catalyse significant venture capital investment and pharma interest. All funds generated will be reinvested in i) Pangea’s next-generation TrkB follow-up compounds currently under development, ii) pipeline compounds based on Pangea’s AI discovery platform and iii) achieving our ambition of becoming a leading CNS-focused Biotech company with a large portfolio of nature-inspired assets developed using our technology platform.

Keywords: cognitive impairment,schizophrenia,negative symptoms,neuropsychiatric disorders,clinical research,trkb modulator,nature inspired,small molecule,drug development,central nervous system,bdnf
MXI: MATRIX CHARGING INTERFACE INTEGRATING EVS INTO A SMART ENERGY SYSTEM (MXI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Easelink designs, develops and markets a revolutionary automated charging solution integrating electric vehicles (EVs) into a smart energy system: Matrix Charging (MC). We are the first true interface technology that connects all relevant players along the automotive and energy value chain (OEMs, Tier1s, infrastructure suppliers + providers, EV drivers). Easelink was founded in 2016, with its headquarters in Graz, Austria and additional offices in Munich, Germany and China, thereby being located in two European automotive hotspots (Tier 1s in Graz, OEMs in Munich) and the largest EV market. We have been fast-growing from the get-go and boast a current headcount of 38 people. Our revenue model is based on licensing our technology with additional direct sales generated by own efforts. Our mission is to set the global standard for automated charging. We want to be the go-to provider for a frequent and broadly rolledout automated charging solution for EVs and thereby solve the last hindrances that currently hold back e-mobility. Our vision is a world where EVs are automatically connected to the grid everywhere and at any time. A car charging at the next public pad while grocery shopping. A car being connected in the office garage during a long workday, making use of renewable energy produced. We envision a world, where EVs are integrated into the grid and energy is used when needed, as needed. Cars become driving energy storages, feeding back into the grid at high demand times. Matrix Charging is a combination of the MC connector (MCC) installed under vehicles and the MC pad (MCP) placed on roads or portable (plug&play): The Matrix Charging System comprising a vehicle unit (MCC) and an infrastructure unit (MCP). Each MCC is compatible with each MCP, supporting charging wherever, whenever and creating a network effect.

Keywords: ev charging,automated charging solution,smart energy system,roll out of e mobility,smart grid operation,bidirectional charging,vehicle to grid,handsfree charging,conductive charging
SENSY, the first implantable sensory feedback restoration system for treating neuropathic pain (SENSY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 30.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Chronic neuropathic pain affects a substantial portion of the global population, leading to a reduced quality of life and significant healthcare costs. Current treatment options often fail to provide effective and long-lasting relief, leaving patients with limited alternatives and ongoing discomfort. In response to this unmet medical need, SensArs, has developed a groundbreaking solution to revolutionize neuropathic pain management. Their innovation, the SENSY system, a closed-loop neurostimulation technology that combines intra-nerve electrode arrays and proprietary algorithms. The system is implanted in peripheral nerves, enabling highly selective stimulation of specific areas affected by neuropathic pain. This results in the revival of natural sensations and the elimination of pain. During the EIC project, SensArs aims to complete the optimisation & clinical validation of SENSY by conducting pilot trials, securing regulatory approvals, commercialise & scale up the business to a global level.

Keywords: neuromodulation,personalised treatment,chronic neuropathic pain,rehabilitation,algorithms and complexity
Precision Fermentation based ChoViva Butter as Cocoa Butter Alternative (PreFer ChoCo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Planet A Foods aims to revolutionize the confectionery and general food industry with sustainable ingredient alternatives. Alongside our initial product ChoViva Concentrate, a cocoa-free alternative to cocoa powder, we are currently in the process of developing a product targeting to replace conventional cocoa butter - ChoViva Butter. Our process utilizes our proprietary Lipid-Technology Platform and own yeast strains to achieve high scalability in order to be up to 35% cheaper than conventional cocoa butter, making it a highly attractive option for chocolate manufacturers. It mimics the properties of cocoa butter offering similar fatty acid, triacylglyceride profiles, and melting behaviour like no other product. ChoViva Butter is highly sustainable with only 0.03% water waste and reduced CO2 emissions by 91.7% when compared to unsustainable and conventional cocoa butter. With a diverse and highly skilled team, we plan to become a leading B2B supplier in the cocoa butter market. We focus on superior quality and affordability, with plans to expand into the larger edible fats and oils market leveraging our Lipid-Technology Platform. Our products have already garnered interest from major players in the confectionery industry, positioning them to redefine global chocolate production standards with sustainability at the forefront. Currently, numerous potential investors hesitate to commit despite a large interest in our product, as there is still risk involved in the last steps of the development of ChoViva Butter. Therefore, we require the EIC to support the finalization and go-to-market of our ChoViva Butter, especially developing and building large-scale production capabilities, obtaining the Novel Food certification and successfully placing ChoViva Butter in the global confectionery market.

Keywords: metabolic strain engineering,yeast lipid fermentation,lipid technology platform,chemical engineering,chocolate industry,precision fermentation,sustainability,cocoa butter alternative,choviva
Solar Hybrid Automated Performance Enhancement (SHAPE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2230000.0
EU funding (EUR): 2230000.0
Participants: 1
Project status: SIGNED

SHAPE is a project that is destined to revolutionise the solar hybrid sector by radically rethinking and enhancing solar hybrid and CSP (Concentrated solar power) technologies. SHAPE represents the transition from human to AI powered design and operation of plants aiming for standardisation and digitalisation of operation. At the heart of our game-changing system we have a combination of accurate and industrially accepted physical and processes modelling capabilities, and highly advanced mathematical optimisation engines based on AI methods. They are built to obtain the best techno-economic solution among tens of thousands of potential sub-optimal results The SHAPE project proposed by SUNNTICS aims to demonstrate the benefits of its solutions at a large, already operational commercial site. Doing so will secure a major launching customer but will also lay the basis for deploying SUNNTICS’s technology in multiple sites across the southern EU and exporting to sun-rich countries worldwide. The growth of solar hybrid technology to power green hydrogen production will ultimately require hundreds of such sites worldwide.

Keywords: solar hybrid plant,concentrated solar power,optimization,plant management,plant design
The flying timber: A glocal political ethnography of balsa extractivism and its implications for its main region of supply: the Ecuadorian Amazonia. (FlyBal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Balsa (ochroma pyramidale), is a type of timber that is mostly produced in Ecuadorian Amazonia. In fact, Ecuador is the world’s largest balsa producer 1 and it has been so for decades. Balsa is not the world’s lightest timber, yet it is the most resistant among the light, and it is used in aero-modelism. Planes’ wings usually have a skeleton made of balsa. Yet, that’s not the only enterprise in which it is used, nor is aero-modelling what inspirred this research project. It started with an ethnographic observation: when leaving the Amazonian Kichwa community in which I have been conducting research over the past two years, I found out that some of the fluvial and terrestrial passages from and to the Amazonia were blocked by local communities with the aim of not permitting the entry to balsa “mafias”. I was intrigued and did some research: apparently the demand for balsa has skyrocketed over the past few years, and illegal balsa trade is -indirectly - responsible for some of the Amazon’s illegal deforestation. The – unlikely – reason is green energy: balsa is the core material used in the construction of wind turbin-blades, and since wind-farms have multiplied impressively all over the globe in the quest for green energy solutions, so has the demand for balsa, which is -ironically – bringing about deforestation in the Amazonia. Through the combination of desk-research on the political economy of global balsa commodity circulation, and ethnographic fieldwork in Ecuador, the “other” side of green energy commodity chain- and focusing on balsa extraction processes and the effects it has on local communities’ livelihoods and well being, this project intends to connect the dots, and tell “the big story” through “the small one.” It is planning to explore the relationship between the global quest for green energy and its local counter-effects, through the case of balsa commodification and commercialization at its main region of supply, Pastaza region of the Ecuador.

Keywords: global sociology,global ethnography,extractivism,latin america
Industrialisation platform for net-zero transport (SCALE INDUSTRY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The world faces a critical challenge in decarbonizing its manufacturing sector, which accounts for nearly 30% of energy-related CO2 emissions. The urgency to transition to net-zero technologies is hampered by systemic bottlenecks in industrialization, particularly in sectors such as batteries and fuel cells. Delays in scaling manufacturing capabilities result in missed climate targets, economic losses, and increased reliance on fossil fuels. The automotive and aerospace industries alone plan substantial investments, yet inefficiencies lead to cost overruns and potential offshoring of production, jeopardizing European jobs and competitiveness. To address these challenges, we have developed an AI-enabled "industrialization cockpit" that revolutionizes the way manufacturers approach production scaling. This platform integrates strategy, supply chain, and process planning into a unified system, significantly reducing time-to-market by up to 80% and costs by 75%. By automating decision-making and providing real-time insights, our solution mitigates risks and enhances the overall efficiency of the industrialization process. The EIC Accelerator grant funding is pivotal for our company, enabling us to scale our innovative technology and broaden its impact across Europe. This funding will facilitate the development of our platform, empowering manufacturers to achieve net-zero goals more effectively and positioning Europe as a leader in clean technology production. Through this initiative, we aim to transform the manufacturing landscape, ensuring that European industries remain competitive and sustainable.

Keywords: automotive,aerospace,industrialisation,scale up,net zero
Cascade Processes for Sparse Machine Learning (SPARSE-ML)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1499285.0
EU funding (EUR): 1499285.0
Participants: 1
Project status: SIGNED

Deep learning continues to achieve impressive breakthroughs across disciplines and is a major driving force behind a multitude of industry innovations. Most of its successes are achieved by increasingly large neural networks that are trained on massive data sets. Their development inflicts costs that are only affordable by a few labs and prevent global participation in the creation of related technologies. The huge model sizes also pose computational challenges for algorithms that aim to address issues with features that are critical in real-world applications like fairness, adversarial robustness, and interpretability. The high demand of neural networks for vast amounts of data further limits their utility for solving highly relevant tasks in biomedicine, economics, or natural sciences. To democratize deep learning and to broaden its applicability, we have to find ways to learn small-scale models. With this end in view, we will promote sparsity at multiple stages of the machine learning pipeline and identify models that are scaleable, resource- and data-efficient, robust to noise, and provide insights into problems. To achieve this, we need to overcome two challenges: the identification of trainable sparse network structures and the de novo optimization of small-scale models. The solutions that we propose combine ideas from statistical physics, complex network science, and machine learning. Our fundamental innovations rely on the insight that neural networks are a member of a cascade model class that we made analytically tractable on random graphs. Advancing our derivations will enable us to develop novel parameter initialization, regularization, and reparameterization methods that will compensate for the missing implicit benefits of overparameterization for learning. The significant reduction in model size achieved by our methods will help unlock the full potential of deep learning to serve society as a whole.

Keywords: deep learning,sparsity,theory,lottery tickets,cascade processes,complex networks,random graphs
Breakthrough dual-action OTC tablet for treatment and prevention of both bacterial and fungal vaginitis (pHyph)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-04-01
End date: 2026-07-31
Duration (months): 28.0
Total project cost (EUR): 3799375.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

There is a large unmet medical need for an efficient and highly accessible solution that can simultaneously treat and prevent BV and VVC, while removing the abuse of antibiotic and antimycotic drugs to avoid further antimicrobial resistance. The inefficacy of current solutions is demonstrated by the huge burden that BV/VCC bring to the society in terms of economic expenses (more than €3.8Bn annually), preterm births (5.4M per year), the huge prevalence of both diseases (more than 500M cases per year) and the deteriorated QoL for women. Gedea has developed pHyph, a patented pessary that due to its safe profile will be highly accessible as a first line OTC solution. pHyph is an antimicrobial-free dual solution with a new mode of action that targets both the treatment and prevention of BV and VVC, without the need of pathogen identification. pHyph will be commercialized as an OTC product in pharmacies and drug stores – where 90% of women with VI look for a treatment to the infection. The business model targeted for pHyph is a well-established and successful B2B2C model for this type of product. Our business model is highly scalable via planned partnerships with distributors and pharma companies, that will facilitate accelerated commercial deployment & scale up of our business throughout Europe & beyond. Gedea core team is composed by 9 persons with over 250 years of experience combined, including experts in clinical research, bioorganic chemistry, regulatory affairs, marketing, and business development. The company received the award "Rapidus Company of the Year" and appeared on Labiotech's list "The 20 European Biotech Companies to Watch in 2022". During this project, Gedea will perform the necessary clinical trials, CE-Mark Certification and pre-market activities to commercialize pHyph (TRL 9 by 2026). In order to do so, Gedea requires an estimated expenditure of €11.9M, which is requested to the EIC through both Grant and Equity fund.

Keywords: bacterial vaginosis,vaginal infections,vaginitis,vulvovaginal candidiasis,antimicrobial resistance,vaginal pessary,lactobacillus,vaginal ph modulation
Unlocking the power of wastewater to produce H2 and green chemicals with microbial electrolysis (AquaFuels)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Aquature’s vision is to change the way to manage high-strength industrial wastewater. Imagine harnessing the hidden potential of organic contaminants to not only purify industrial wastewater but also generate clean energy and valuable green chemicals. Current wastewater treatment methods rely on century-old technology to get rid of a problem. These old-fashioned methods eat energy, while wastewater is in fact a source of chemical energy. Aquature’s mission is to unlock power within wastewater. Water is a vital raw material, and the same goes for solid waste. Aquature’s ambition is to capitalize on both liquids and solids by i) returning clean water for reuse and ii) harnessing the energy from the solids in wastewater to produce green H2 and green chemicals in a more cost-efficient way than traditional processes. Aquature provides the equipment and services to break down organic matter using electrically active bacteria in proven electrochemical cells while producing clean water. Globally, billions of euros are spent treating trillions of litres of wastewater every year, consuming 3% of global energy consumption at 3% of global GHG emissions.. However, wastewater will become a renewable resource through Aquature, saving significant quantities of energy and money by converting contained organic pollutants into electricity, hydrogen and high-value green chemicals, such as caustic soda, ethanol and acetic acid.

Keywords: wastewater treatement microbial electrolysis cell