Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gender Dynamics and Quotas: Unlocking the Potential of Political and Economic Empowerment (GAPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Achieving gender equality in politics, the labour market, and public life is essential for fostering a fair and inclusive society. This project explores the effectiveness of key policy tools aimed at closing gender gaps across Europe. The first part of the study examines the impact of gender quotas - both hard quotas like parity laws and soft quotas like voluntary party commitments - on women’s representation in the European Parliament, drawing on data from the 2024 EU elections. Additionally, it analyses growing gender-based disparities in trust and perceptions of public institutions. The second part of the project evaluates the role of female politicians in shaping gender equality policies, with a specific focus on Denmark’s recently introduced earmarked parental leave reform. Through innovative quasi-experimental research methods and text analysis, the project will assess both political discourse and policy outcomes, providing valuable insights into how gender equality initiatives impact public life and governance across Europe. Ultimately, this research will contribute to a deeper understanding of the demand for and effectiveness of gender equality policies, as well as their broader social and political implications.

Keywords: policy evaluation gender quotas trust in institutions survey design
Low-Energy Electron Multiplication On Nanostructured Solar cells (LEEMONS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: France,Germany,Poland,Switzerland
Call: Next generation of renewable energy technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 2660034.0
EU funding (EUR): 2660034.0
Participants: 9
Project status: SIGNED

Photovoltaics (PVs) cells will play a major role in the worldwide transition to more sustainable sources of energy. There has been a vast scale up in the deployment of PV cells driven by the drastic price reduction of Si photovoltaics (Si-PVs). It is now widely accepted that increases in PV efficiency are key to pushing PV deployment further and continuing to lower costs. However, after decades of research and development, Si-PVs are approaching the theoretical limit for power conversion efficiencies (currently 26.8% out of a possible 29.4%) as determined by the Shockley-Queisser limit, due to thermalisation losses. There is currently no commercially deployed technology that can overcome this challenge. The project LEEMONS will make a proof-of-concept demonstration of a new technology – an electron multiplication phenomenon, which overcomes these fundamental thermalisation losses by converting high energy electrons into several lower energy electrons. This solution is compatible with 80% (possibly 95%) of current PV manufacturing capacity as well as future designs and hence requiring little change on the current manufacturing lines and therefore low capital expenses. LEEMONS project will produce prototypes fabricated from state-of the art European PV cells (PERC based and Heterojunction solar cells). These integrated cells shall demonstrate a gain in power conversion efficiency, thus opening up a new technological area, which will help deliver both economic, societal and environmental benefits.

Keywords: solar energy,photovoltaics,nanotechnology,electron multiplication,ion implantation
Machine learning for Sciences and Humanities (SMASH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia,Netherlands,Italy,United States,Switzerland,Belgium,United Kingdom,Spain,Israel,Norway,Cyprus,Brazil,Bulgaria,South Africa,Germany,Czechia,Canada,Greece
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 4776000.0
EU funding (EUR): 4776000.0
Participants: 39
Project status: SIGNED

SMASH is a brand-new training and research programme to be co-funded by the Slovenian Ministry of Science, Education & Sport. The Beneficiary, the University of Nova Gorica, is a research-focused university, situated at the Italian border, that boasts a 51:49 female:male ratio among its 200+ staff. The programme is designed to enhance the career prospects of outstanding post-docs from around the world, while strengthening Europe's human capital in R&I. Fifty talented individuals will be hired by five of Slovenia’s leading institutions, allowing them to expand their own research ideas based on access to the data-science potential of the Vega HPC supercomputer, the first such facility of the EU’s €-multi-billion HPC initiative. With a diverse group of Associated Partners, including top SMEs from Slovenia and the EU as well as world-leading institutions like UC Berkeley, SMASH will form a close-knit community with a single unifying concept: the use of cutting-edge data science to answer some of the world’s most challenging questions. These include predictions related to the impacts of climate change, the development of personalised medicine, finding answers to fundamental questions about our Universe and digging deep into the fundamentals of language and how we communicate. SMASH will guarantee a recruitment process based on openness, transparency, impartiality and equality, and will ensure neutrality by giving all selection power to external experts, setting an example for the region. Top-level training in applications of machine learning, that is one of today’s most transferable skills, will be complemented by rich soft-skill training opportunities, developed in collaboration with some of the world’s best experts, including CERN's Learning Hub. The impact of the programme will be felt for decades, both in the local research landscape and across Europe as the researchers take their skills to pursue their careers on the strength of their successes in SMASH.

Keywords: data science,machine learning,artificial intelligence,hpc infrastructure,climate,sea levels,astro particle physics,collider physics,linguistics,animal communication,personalized medicine
Accelerating a paediatric formulation of ivermectin for the control of Neglected Tropical Diseases (IVM-KIDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Spain,Kenya,Ghana,Congo, The Democratic Republic of the,Switzerland,Rwanda
Call: Accelerating development and integration of therapeutics against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 5498750.0
EU funding (EUR): 5498750.0
Participants: 9
Project status: SIGNED

Ivermectin is a critical drug for the control and elimination of multiple neglected tropical diseases. Currently, children weighing under 15kg do not receive treatment with ivermectin due to an absence of safety data and the lack of a suitable paediatric formulation. Consequently, these children are left untreated. This results in considerable morbidity at the individual level and a reservoir of infection at the population level. These issues create a critical barrier to achieving the goals of the 2030 NTD roadmap. In 2023, the World Health Organization (WHO) conducted a Paediatric Drug Optimisation (PADO) review to identify critical needs for therapeutics in children affected by NTDs. Recognising the central role of ivermectin in the control of NTDs, along with the opportunity to accelerate progress by expanding treatment to paediatric populations, this report highlighted a paediatric-friendly ivermectin formulation as as a critical priority for NTD programmes worldwide. A novel orodispersible formulation of ivermectin provides the opportunity to address this critical gap. Our consortium brings together leading academic and drug development partners across Europe and sub-Saharan Africa to address this global priority need, with crucial experience in novel therapeutics and navigating the European and African regulatory landscapes. Our consortium will deliver studies to demonstrate the safety, pharmacokinetics and efficacy of the novel, orodispersible formulation of ivermectin suitable for use in young children. This will include conducting a large safety study across West, Central, East and Southern Africa to demonstrate the efficacy of this agent for the treatment of soil transmitted helminthiasis. We will work closely with European and African regulators to ensure that our project delivers both the scientific and regulatory data required to bring this agent to market and transform access to effective NTD treatment for for millions of children worldwide.

Keywords: ivermectin,paediatric drug development,ntds,soil transmitted helminths,onchocerciasis,lymphatic filariasis
Investigating the Interplay of Natural Killer Cells and Microbiome in Non-Hodgkin's Lymphoma (LINK-M)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

Natural Killer (NK) cells have a critical role in anti-cancer immunity and recently the influence of the microbiome in cancer immunotherapy was shown. Comprehending the complex interplay between the expression of NK cells ligands involved in immune evasion mechanisms and the microbiome is crucial for achieving immunotherapy success. Diffuse Large B Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) are two types of Non-Hodgkin Lymphomas (NHL) characterized by accumulating B lymphocytes in lymph nodes, and extranodal sites. DLBCL and FL usually show aggressive and indolent behavior respectively. DLBCL, includes the known subtypes germinal center B-cells (GCB) and activated B-cells (ABC), and, like the DLBCL-GCB subtype, FL have a germinal origin as well. The mechanism involved in the immune-microbiome interplay are not clearly understood, hampering the improvement of therapeutic possibilities. The objective of this study is to reveal the complex interplay between the NK cells and the microbiome in DLBCL and FL patients and harness its therapeutic potential. To achieve this, I will use single-cell RNA sequencing and flow cytometry to analyze the composition of NK cells dissociated from DLBCL and FL samples. Then, I will use correlative analyses to identify the NK ligands/receptors that are more expressed in patients with low diversity and high variability microbiome. Ultimately, I will address the impact of this correlation in the response to immunotherapy. The results will pave the way for patient risk stratification establishment and new treatment options approaches. Conducting this project at the Tumor Stroma Interactions (TSI) group will provide me a solid scientific basis as well as technical development for further progressing my scientific career.

Keywords: microbiome,immune response,microenvironment,hematology,lymphoma,natural killer cells,cancer immunology
Stabilizing pharmaco-active Membrane proteins with Zwitterionic polymers and leveraging Surface Plasmon Resonance as an Analytical platform (ZwitterMPs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Taiwan, Province of China
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-02
End date: 2028-03-01
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 2
Project status: SIGNED

Membrane proteins, particularly G-protein-coupled receptors (GPCRs), represent 25-30% of current drug targets. Among them, metabotropic glutamate receptor (mGluR), a Class C and group 1 type GPCR, is emerging as an attractive therapeutic target for various neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson's disease, autism spectrum disorder, schizophrenia, and neuropathic pain. Despite the availability of its complete structure, biophysical characterization and drug discovery efforts targeting mGluR have been hindered by the challenges in obtaining stable, active conformations of this receptor for in-vitro studies. To overcome this impediment, we will utilize amphiphilic zwitterionic polymers, for stabilizing mGluR. Carefully synthesizing copolymers can mimic the native lipid environment and maintain the receptor's structural and functional integrity. Zwitterionic polymers, with their unique molecular architecture featuring both anionic and cationic groups, structure surrounding water molecules, creating super-hydrophilic surfaces ideal for stabilizing membrane proteins with exposed hydrophobic domains. To evaluate this stabilization strategy, we first aim to employ the label-free bio-analytical technique of surface plasmon resonance to immobilize the mGluR-polymer complex. Secondly, we will investigate binding kinetics, affinities, and allosteric modulation of mGluR1 receptor to obtain valuable insights into protein-drug interactions. We anticipate this innovative strategy will address the existing challenges in stabilizing mGluR, offering improved stability, reduced complexity, cost-effectiveness, and higher yields over conventional methods. Moreover, it will accelerate drug screening practices targeting mGluR and other challenging membrane protein targets in the long run, thereby contributing to developing novel therapeutics for neurological and psychiatric disorders.

Keywords: membrane proteins,surface plasmon resonance,zwitterionic copolymers,mglur1,drug discovery
Quantum dynamics of floppy systems beyond Coulomb interactions: magnetic and parity-violating effects (QDMAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Hungary
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 141782.4
EU funding (EUR): 141782.4
Participants: 2
Project status: CLOSED

Chemistry is developed with the improvement of experimental and theoretical spectroscopy. A well-known approach for molecular vibration is based on harmonic oscillators, but it cannot be used for floppy systems. To analyze spectra of floppy systems, the exact quantum dynamics (QD) methodology based on a numerically ‘exact’ solution of the (ro)vibrational Schrödinger equation has been developed. It may appear that ro-vibrational spectroscopy is well established, based on the electronic Schrödinger equation with Coulomb interactions, but two additional effects that split molecular spectra remain: a) magnetic interactions due to nuclear spins, and b) parity-violation interactions, which is due to the electroweak force, causing tiny energy differences between enantiomers. The magnitude of a) is on the order of several tens of GHz (109 Hz), which is observable in the high-resolution spectrum. The magnitude of b) of a current target molecule is predicted about a few mHz (10-3 Hz), which is smaller than the current precision of the best experiments. The suggestion of new target molecules with large PV effects is required. These effects have been investigated for rigid systems, but never for floppy systems, where new coupling of ro-vibration and magnetic interactions, and strong enhancement of PV effects may be present. In this project, I investigate a) and b) of floppy systems by developing new QD methodology and by obtaining molecular properties (spin-rotational constant and PV energy), based on electron correlation theory. The objectives of this project are as follows: i) formulation, implementation, and application of QD with magnetic interaction for floppy systems, ii) theory development of QD for methanol-like molecules, and iii) QD application for chiral methanol-like molecules. This project provides the development of the exact quantum dynamics methodology which leads to a complete description of quantum nuclear motion in molecular systems.

Keywords: quantum dynamics of nuclear motion,magnetic interactions due to nuclear spins,floppy systems,parity violating interactions,relativistic electronic structure theory
REcasting psychological interventions for Customizing, Optimizing, Validating, and Enhancing Recovery of chronic pain patients (RECOVER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

Chronic non-cancer pain (CP) negatively impacts all areas of functioning, severely limiting quality of life and increasing the risk of mental disorders. Psychological interventions are a key part of treatment, with meta-analyses showing small to moderate effects on pain intensity and associated outcomes. Psychological interventions are themselves complex, with multiple, distinct components. There is presently no taxonomy of these components and no information about which components are the active ingredients supporting the treatment effect, which are redundant or even harmful and whether some patients respond better to some components rather than others. The RECOVER project is premised on two principles: (1) to optimize treatments, we need to know their building blocks; (2) to improve treatment response, we need to examine patient-level predictors of responses. The aims of RECOVER are (a) decomposing complex psychological interventions for CP; (b) re-evaluating efficacy by examining the specific contributions of components and combinations; c) examining patient characteristics (e.g.,age, gender, pain history) predictive of better response to components or combinations and d) creating an open app based on the project findings, allowing users to personalize treatment by selecting the most effective components. The methodology will involve retrieving and reutilizing individual participant data from randomized controlled trials of psychological interventions for CP and using advanced meta-analytic methodology such as component network meta-analysis. Training activities will span the entire project duration, and the outcomes will be presented at international conferences and submitted to top-tier, peer-reviewed journals. RECOVER has the potential to make important strides toward optimizing and personalizing psychological treatment of chronic pain.

Keywords: pain chronic pain psychological treatment individual participant data network meta analysis active ingredients personalised treatment
Deepfake Evidence and Technology for Forensic Content Oversight and Research (DETECTOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Italy,United Kingdom,Germany,Poland,Finland,Netherlands,Portugal
Call: Open Topic (HORIZON-CL3-2024-FCT-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 4489406.1
EU funding (EUR): 4489405.5
Participants: 17
Project status: SIGNED

AI is transforming law enforcement, offering new tools for policing but also enabling advanced criminal tactics that challenge traditional methods. The global nature of crime, including cyber threats, trafficking, and terrorism, calls for innovative solutions as LEAs face vast data volumes and increasingly sophisticated criminal activities. AI has raised concerns with deepfakes—highly realistic but fake audio, video, or text that can depict individuals saying or doing things they never did. Deepfakes pose serious risks, impacting politics, economy, and social trust. Examples include fabricated videos of political figures and voice-cloned audio for financial fraud, often spread through social networks to deceive and defraud on a large scale. Forensic institutes and courts struggle to differentiate authentic evidence from AI fabrications, especially in cases involving national security. Despite promising detection research, existing methods fall short as current models rely on limited, non-diverse datasets and produce results with limited legal admissibility. The DETECTOR initiative aims to address these challenges, supporting LEAs and forensic experts in analyzing altered media. It offers an integrated solution through cross-border collaboration among AI researchers, LEAs, forensic scientists, legal experts, and ethicists. DETECTOR’s goals include: developing specialized tools for detecting media manipulation, creating comprehensive datasets, researching digital evidence exchange across borders, engaging stakeholders, informing policymakers, and training forensic experts in digital media and AI. Through these efforts, DETECTOR seeks to safeguard digital evidence authenticity and enhance forensic capabilities to counter AI-driven media manipulation across Europe

Keywords: generative ai media,deepfakes