Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Key Inorganics for Spintronics and MagnetoElectrics (KISS ME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 123783.68
Participants: 1
Project status: CLOSED

Magneto-electric (ME) materials have been attracting considerable interest for their potential application in e.g. data-storage. Up to now, applications have been hindered by the weakness of the polarization generated by the ME effect. KISS-ME relies on the recent discovery by the host laboratory of inorganic compounds built on Low-Dimensional magnetic units. Dealing with 1D and 2D topologies carrying macrospins with large magnetization, they form the ideal playground for enhanced ME properties. The applicant proposes to quantify the ME performances on such phases and on new specifically-designed ones. This will allow to deduce the ideal chemical/structural/magnetic context for giant ME. It is a prerequisite for the prediction and synthesis of optimal multiferroics, limited so far by weak ME polarization and low temperature. Our multi-step strategy includes Design, Elaboration, Crystal Growth, Structural and Physical Characterization and theoretical modeling of relevant low-D ME. Concerning the host-available samples, source of inspiration, it concerns original inorganic compounds with remarkable magnetic properties, i.e. rare examples of low-D ferromagnetic compounds with incommensurate structures, large magnetic periodicities, inorganic single-chain-magnets, and 2D-Ising FM… Their structural topologies associated with strong and sizeable spin-orbit couplings (SOC) and original spin-flip-like transitions give all pre-requisites for enhanced magneto-electric (ME) couplings and electric polarization of magnetic origin (type II multiferroics). For the conception/Design of further compounds, we have to handle individual magnetic units and well adapted spacers, according to incremental magnetic dimensionalities. In pseudo-3D phases (i.e. isolated blocks), room temperature magnetic orderings are expected, a challenging step of industrial relevance. The KISS-ME research relies on the acquisition by the host PPMS system, that the applicant will dedicate to the project.

Keywords: multiferroic materials,structure properties relationship,low dimensional magnetism
Signal Transduction in Organic Materials (STORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2022-03-31
Duration (months): 60.0
Total project cost (EUR): 1998985.0
EU funding (EUR): 1998985.0
Participants: 1
Project status: CLOSED

It is the overall aim of this project to use responsive catalysts to introduce signal transduction cascades in soft materials, enabling autonomous, programmable and amplified response of soft materials to chemical signals from their environment. 'Smart' soft materials could find many important applications ranging from personalized therapeutics to soft robotics. However, as most molecular materials are unable to communicate, or even respond to, changes in their environment, truly smart materials are still far out of reach. Signal transduction is one of the primary processes used by living cells to react to events taking place in their environment, often involving a signal triggering enzymatic activity, leading to a cellular response. Such rudimentary communication is entirely non-existent in synthetic materials. I here propose the introduction of catalysis-based signal transduction between chemical systems to enable synthetic materials to respond autonomously to events taking place in their environment. Key to achieving this objective will be the development of switchable catalysts, using signals originating from chemical events to change catalytic activity, and coupling changes in catalytic activity to responses in soft materials. In achieving these objectives, I will develop new design strategies for responsive soft materials, enabling control over material formation and response in time and space, through autonomous reaction to chemical signals. This will allow the development of new actuators, self-healing materials, sensors, therapeutics and self-regulation and self-correction of material assembly. It will also constitute an entirely new role for catalysis, as catalysis will be engaged to constitute a first step towards achieving communication between artificial chemical systems.

Keywords: catalysis,active materials,responsive materials
Developing Stretchable Conductive Fibres and their Implementations in Wearable Electronics (Wearonics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

Europe needs to take action to develop stretchable conductive materials to lead to the wearable electronics industry, which will be worth over $30 billion dollars in 2020. Although flexible electronics are dominating the current wearonics industry, their applications are restricted due to significant reduction in their conductivity under the applied strain. All stretchable conductors with mechanical compliance materials like human skin are required for epidermal electronic devices and wearable electronics. The ideal solution to this problem would be using a stretchable conductive material that can be woven into washable and breathable fabrics, which remains a significant challenge. To address this challenge, I have formulated an innovative and interdisciplinary strategy based on my research experience to develop stretchable conductive fibres (SCF) using silver nanowires and spandex fibre. After developing SCFs, I will bring together diverse academic and industrial experts to utilize SCFs in 4 different research environments. First, I will receive intensive training at the Wireless Communication and Research Lab to utilize SCFs in wireless communication and pervasive computing systems. Then, I will integrate these systems into the disabled friendly apparels at Universal Textile Centre. Finally, I will be seconded to two industrial organisations, ComfTech and Antelope, to create SCF based prototypes of Health Monitoring Systems and Electro Muscle Stimulation technologies. This fellowship will allow me to gain new expertise in multiple disciplines, and build complementary international partnerships between academia and industry, which will enable me to enhance my independence as a researcher in the wearonics field. The successful completion of this timely and innovative project will result in an advanced material that will contribute to the competitiveness of Europe in the wearonics field.

Keywords: stretchable conductor,conductive fiber,smart textiles,wearable electronics,wireless health monitoring,pervasive computing,silver nanowires,surface instabilities,electro muscle stimulation
The NanoLiter Reactor sequencing -- Quick and cost-effective method to develop microbial strains (FGen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Demand in bioproducts is increasing to answer the food needs required to feed the growing population. The current manufacturing of bioproducts- vitamins, amino acids, industrial enzymes- is heavily relying on the use of fossil fuels, whereas bio-based production can save water, energy all decreasing waste and costs. The use of efficient microbial strains allows bioproduct manufacturers to do so. The optimization process of the microbial strain is going under several cycles during which culture conditions are modified, and strains genetically modified, making the development long and costly. In addition, the scale-up is often complicated. FGen has developed a nano-reactor mimicking large bioreactor conditions allowing a high throughput screening of microbial strains, easing the scale-up and speeding the screening of the family strain respectively, all decreasing time and development costs. This nano-reactor having shown promising results, FGen aims to compile it with an innovative method to genetically modified the strains. The combination of these two methods will grant large chemical companies and biotech to save up to 3 years and around €45 M for the development of an efficient strain that will be used in the manufacturing of bioproducts. The estimated segment market for FGen is of €20 bn. With a time to market estimated at 3 years, FGen aims to act as service provider with external companies to generate revenues and to work on the development of its own strains to license or sold them. FGen estimates to generate a positive EBITDA of €5 M at 7 years (2025), and to grow-up to more than 100 employees.

Keywords: high throughput screening
Inverse Problems and Flows (IPFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1133236.0
EU funding (EUR): 1133236.0
Participants: 1
Project status: CLOSED

In this project, we propose to study mixing and rigidity properties of a large class of flows in geometry and dynamical systems using novel microlocal and spectral methods. Such methods, recently developed for flows with hyperbolicity, are based on the construction of new functional spaces, adapted to the considered flow, on which the generating vector field is Fredholm with discrete spectrum, known as the resonance spectrum. We want to apply these tools to the following categories of long-standing problems: 1) Geometric inverse problems: boundary and lens rigidity problems, analysis of the X-ray transforms for geodesic flows and its applications to Calderon and Gelfand inverse problems. 2) Rigidity for Anosov flows: determination of the minimal regularity of the stable/unstable foliations providing rigidity, rigidity questions for regular conjugacies of flows. 3) Rate of mixing for flows of hyperbolic type: decay of correlations of Axiom A flows, Anosov flows, and their compact Lie groups extensions, frame flows of negatively curved manifolds. 4) Resonances for locally symmetric spaces: relation between resonances of the flow and the spectrum of Laplacians on bundles. To address these problems, we will develop a thorough analysis for the regularity and the long time properties of solutions to transport equations. We are convinced that the proposed approach will provide solutions to these problems, which have been out of reach for a long time.

Keywords: inverse problems,geodesic flows,hyperbolic dynamic
European Newspace Vertical Orbital Launcher (ENVOL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Norway,Sweden,Belgium,Norway,France,Netherlands,Netherlands
Call: Access to space (H2020-SPACE-2019, 2019)
Start date: 2020-02-01
End date: 2023-04-30
Duration (months): 39.0
Total project cost (EUR): 3987416.25
EU funding (EUR): 3987416.25
Participants: 12
Project status: SIGNED

ENVOL main objective is to provide Europe its prime commercial, competitive and green launch service, utilizing a true New Space approach to offer low-cost, frequent and flexible access to space to small satellites in the range of 100 to 200 kg by 2024. To achieve this goal, the tip of the spear of European innovative space launch companies has joined forces to develop a vertical orbital launch system that will: • Act as an accelerator for the growth of the European New Space economy; • Be competitive and prevail in a contested and global market; • Attract enough investment to reach the tipping point of commercialization; • Target achieving the first European orbital launch from Continental Europe; • Compete for the EC Horizon Prize on European Low-Cost Space Launch; • Be the first orbital launcher worldwide to use green hybrid rocket propulsion. The project will run for 36 months, with 9 industrial companies from 7 European countries. The total EC contribution is 3 987 416 Euro, and the main outputs of ENVOL are: • A detailed definition of an innovative and industrial low-cost European launch system • A total of four ambitious launch vehicle demonstrators on the turbopump, tank and structures, launcher avionics and payload avionics, advancing the maturity of critical launcher technologies to ensure market readiness and competitiveness. • A business plan grounded by industrial expertise, along with a development plan and the identification of the organization capable to attract investments and to ensure that the work performed in this project transforms into a commercial activity servicing the small satellite launch market in Europe and beyond.

Keywords: launch system,hybrid propulsion,composite tank
Biochemical Characterization of the Apt1/Cdc50 Complex (BiCoACC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Cryptococcus neoformans is an opportunist fungal pathogen lethal for patient with AIDS. Treatment options are limited and there is an urgent need for the discovery of anti-fungal drugs. The membrane proteins Apt1 and Cdc50 from C. neoformans were identified as potential drug targets since it is involved in antifungal resistance and pathogen’s virulence. Apt1 belongs to the P4-type ATPase family and together with Cdc50 proteins they are involved in the maintenance of phospholipid asymmetry in biological membranes. In this project I plan to biochemically characterize Apt1/Cdc50 from C. neoformans, to identify inhibitors and functionally impaired mutants of this complex. These in vitro findings will be translated in vivo in C. neoformans cultures. I plan to join the Laboratoire des Protéines et des Systèmes Membranaires (LPSM) at the CEA Paris-Saclay, a world-leading lab on P4-type ATPases, where I will set up protocols for the expression and purification of the Apt1/Cdc50 complex expressed in Saccharomyces cerevisiae. Furthermore, thanks to my expertise in membrane protein reconstitution in liposomes and functional analysis, I will set up an assay to monitor in vitro phospholipid transport, an expertise still lacking at the LPSM. Using purified functional Apt1/Cdc50 complex we will screen a chemical library to identify inhibitors of this complex. In parallel a structure-function study of the complex using directed mutagenesis will be conducted. Finally, in vitro findings will be translated in vivo thanks to a collaboration with Pr Kronstad (University of British Columbia), a world expert on C. neoformans pathophysiology, where C. neoformans cultures are available. This multidisciplinary project will benefit from the expertise of the host institution on P4-ATPases, my knowledge on membrane protein reconstitution in liposomes, and the experience of Pr Kronstad on in vivo study of C. neoformans. This would allow a 3-ways transfer of expertise.

Keywords: membrane protein complex,cryptococcus neoformans,flippase,proteoliposomes,p4 atpase
Past, present and future Exchanges of CArbon and Water between the vegetation and the atmosphere: new insights from analysis and modelling of stable carbon ISOtope data (ECAW-ISO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Water-use efficiency (WUE, the carbon gained through photosynthesis per unit of water lost through transpiration) is a tracer of the plant physiological controls on the exchange of water and carbon dioxide between terrestrial ecosystems and the atmosphere. Rising CO2 concentrations and climate change both affect the stomatal regulation of leaf gas exchange and must influence WUE. However, the magnitude of change in plant WUE estimated by different methods differs strongly amongst studies, indicating unresolved issues. Moreover, current land surface models produce inconsistent and often unrealistic magnitudes and patterns of variability in WUE. This project thus aims at developing the use of carbon isotopes (13C) in terrestrial biosphere modelling to better understand and predict terrestrial carbon and water cycling and to evaluate their representation in models. We will perform a detailed investigation of the influences on discrimination against 13C during photosynthesis and their representation on various scales in the Joint UK Land Environment Simulator (JULES) model, which forms the land component of the UK Earth System Model, and implement the resulting discrimination model in JULES. We will then evaluate historical simulations of past changes in WUE and quantify the relative contributions of each forcing (climate and CO2) on WUE trends. Finally, we will perform projections of future changes in WUE following the 1.5°C and 2°C targets in global average temperature rise by 2100 proposed by the United Nations Framework Convention on Climate Change (UNFCCC). This project will contribute to the establishment of an improved theoretical and empirical basis for next-generation land surface modelling, and will address key uncertainties including the magnitude of changes in carbon and water cycling, which are requested by policy makers.

Keywords: water use efficiency,environmental changes,land surface modelling,carbon isotopes,plant physiology
Abyssomicin C Truncated derivatives against Antimicrobial Resistance (ACT against AMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of antimicrobial resistant (AMR) bacteria. The core of this proposal is to implement an innovative synthesis-oriented strategy to access truncated derivatives of abyssomicin C, a natural product that has shown especially promising antimicrobial activity against the most common strains of antimicrobial resistant bacteria. The multiple routes proposed for the synthesis of the truncated core scaffold are short, robust and amenable for many different variations. This will open up for the possibility to easily synthesise a library of differently adorned abyssomicin C truncated analogues whose antimicrobial activity will be evaluated. Structure activity relationship (SAR) studies aided by computational modeling will be used as an integrated action in the identification of new potent antimicrobial agents. The complementary expertise of the applicant, the host laboratories and the leading experts that will collaborate within this project will be crucial for the realization of all aspects of this multifaceted project. The achievement of the project goals will have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally. This EF postdoctoral training proposal will represent a unique opportunity to the candidate to expand his scientific network in both the academia and the industry, greatly broaden his spheres of action, strengthening his professional maturity.

Keywords: abyssomicin c,antibacterial,antimicrobial resistance,antibiotics,truncated analogues,syhntesis oriented