Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effects of Joint and Multimodal Remembering on Collaborative Learning (DISTRIBUTEDLEARNING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 202405.8
EU funding (EUR): 202405.8
Participants: 1
Project status: CLOSED

Often remembering in learning activities is supported by the social and material environment in which the specific activities unfold. However, so far, little research has been done to integrate the ways in which joint remembering supports collaborative learning tasks in social interactions with other people by means of verbal resources (e.g. lexical and syntactic alignment) with the embodied (e.g. using hands to give directions) and distributed (e.g. relying on tools such as pencil and paper to solve mathematical operations) nature of these practices in relation to educational and work settings. Hence, by paying particular attention to role of joint remembering in multimodal interactions related to educational and work environment, the general aims of this project are: i) to examine how collaborative learning is grounded in successful joint remembering processes; and ii) to explore the central role that the integration of linguistic, embodied, social and material resources plays in collaborative learning activities, by transforming them into distributed practices across space and time. The results of this project will constitute a first step towards a more ecologically valid framework on collaborative remembering and distributed learning, which then could be tested by psychologists, and learning and communication scientists in natural as well as experimental settings.

Keywords: joint remembering,collaborative learning,dialogue analysis,group processes,distributed cognition,multimodal interaction
Development of Heat Insulation Solar Glass for Low Carbon Buildings (DHISGLCB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

This International Fellowship will bring an excellent Chinese researcher Prof. C.H. Young from National Taiwan University of Science and Technology to work in Europe. The project has been carefully chosen to match Prof. C.H. Young expertise in Heat Insulation Solar Glass (HISG) for HVAC (heating, ventilation and air conditioning) with the expertise in sustainable energy and buildings technologies at the University of Nottingham so as to maximize the benefit to Europe. The heat insulation solar glass developed by Prof. C.H. Young can possess higher power generation, heat insulation, saving air condition in summer time and saving heater in winter time. It could be applied both in southern and northern Europe. The participation of Prof. C.H. Young could bring the knowledge and application of heat insulation solar glass and associated technology transfer into European countries. This project will combine the heat insulated glass developed by Prof Young with the six Creative Energy Homes project at the University of Nottingham directed by Professor Saffa Riffat. There are four main steps in this project : (1) Advanced research on the high efficiency heat insulation solar glass to gain more solar power and save more energy consumption to apply in European countries; (2) Testing on BASF Solar Passive House of six Creative Energy Homes at University of Nottingham by adding the application of heat insulation solar glass to monitor its efficiency; (3) Simulation on BASF Solar Passive House by adding the application of heat insulation solar glass to compare with the testing result; (4) Economic and technical assessment of heat insulation solar glass applied on BASF Solar Passive House at Nottingham University. The project could bring out both academic and application contributions on development of low/zero carbon buildings to satisfy the requirement of the Code for Sustainable Homes Equivalent Levels 3 and 6 (zero carbon).

Keywords: g306 energy systems
Kinetic analysis of molecular profiles during human induced regulatory T cell (iTreg) differentiation: an integrative study (ITREGDIFFERENTIATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 197811.6
EU funding (EUR): 197811.6
Participants: 1
Project status: CLOSED

Regulatory T cells (Tregs) suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance, preventing autoimmune disease but hampering tumor rejection. Therapeutic manipulations of Treg number and function are therefore subject to numerous clinical investigations. First in-man trials of adoptive Treg transfer to prevent graft-versus-host disease showed very promising outcomes. Yet, the number of naturally occurring Tregs (nTregs) is minute, encouraging the complementary approach of inducing Tregs (iTregs) from naive T cell precursors. Reinforcing this concept, there are several studies in mice indicating that iTreg transfer may be superior to nTreg transfer. Moreover, iTregs are generated in vivo and ample evidence corroborates that iTregs exert non-redundant functions to maintain health. However, the molecular mechanisms governing iTreg generation in humans are incompletely understood and procedures for human iTreg generation are controversial. Here we will therefore establish and compare different protocols of human iTreg generation juxtaposed with deep molecular profiling using RNA sequencing and DNA methylation analysis. The time-dependent transcriptomic and epigenetic data, capturing molecular events during generation of iTregs, will be subject to bioinformatics analysis. Our integrative analysis will present the first global hierarchical molecular map of pathways driving human iTreg differentiation, which in addition will provide a molecular scaffold enabling deeper analyses to resolve molecular events independent and dependent of established factors. Furthermore, the biological role of novel transcripts, splice variants and epigenetic regulations will be validated biologically by gene knockdown or overexpression experiments. Our interdisciplinary analysis of the molecular mechanisms ruling human iTreg generation may have important implications for our understanding and ability to treat cancer, autoimmune and inflammatory diseases.

Keywords: immune tolerance,regulatory t cells,immune regulation,l202 transcriptomics,l208 epigenetics & gene regulation,l305 cell differentiation-physiology & dynamics,l602 adaptive immunity,l210 bioinformatics
Disentangling landscape and climate effects on insect communities to inform engineering solutions to enhance biological control in a changing climate (CLIMLAND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-08
End date: 2015-04-07
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The impact of climate and landscape components on individuals, populations and communities is largely studied in isolation. In addition, interest in the role of landscape management in the control of agricultural pests is a developing research area. This proposal is an ambitious development of an innovative multi-disciplinary research aimed at understanding the effects of climate and landscape on insect community, composition and species abundance in cereal fields. I will use 3 different Long-Term Ecosystem Research sites (LTER) in France, all of which are agricultural areas which contain a high percentage of cereal fields and a within-site landscape gradient (bocage – open field). These 3 sites are subjected to slightly different climatic conditions, representing a latitudinal gradient throughout France. Insect communities and respective species abundance, linked to aphid pests and their natural enemies (carabids, the generalist predators, and aphid parasitoids), will be compared between each LTER for the two landscape types. More specifically, I will combined an analysis of thermal tolerance (to hot and cold temperatures) of the different species (intra and inter-site analyses), and an analysis of the landscape elements which best explain the community composition. In doing so, the respective importance of landscape components and local climatic conditions for each species will be determined. This will be completed by behavioural and quantitative genetics analyses of the mechanisms used by species to escape harmful climatic conditions. Results will advance our understanding of the likely responses of natural enemies of agricultural pests and enable us to ascertain how landscape management can be adapted to provide protection for the natural enemies to enable continued biological control in the face of climate change.

Keywords: natural sciences,climate,landscape ecology,thermal tolerance,agriculture,pest management,biological control,latitudinal gradient,lethal limits
Talent Agents in the American Film INDustry: how cinematic careers and projects are shaped behind the scenes (TAFIND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 245948.2
EU funding (EUR): 245948.2
Participants: 1
Project status: CLOSED

This project is aimed at exploring a neglected aspect of the movie industry and of the film creation process: the role played by talent agents and its significance for the making of cultural products. Even though agents often remain unseen participants in the day-to-day functioning of the film industry, they hold a key position. This study will provide a detailed account of their professional activity, analyzing the organizational system they belong to and the interdependence mechanisms connecting them to other participants in the film world, to show how they contribute to the making of artists’ careers and cinematic projects and, ultimately, to the manufacture of "popular culture." Exploring agents' perceptions of their work identity, their mission, their distinctive skills will help us to make sense of the occupational models and conventions that currently prevail in that field, in the light of the historical constitution of “agenting” as a profession. In-depth sociological interviews and in situ observations will constitute the main material of this research. Agents’ activity will be analyzed from a sociological viewpoint, at the intersection of several sub-disciplinary perspectives: the sociologies of profession, economy and culture will provide instruments and resources to elucidate how agents participate in shaping cultural markets, with local as well as more global effects. This case study – targeting one of the world leading film industries – can be used as a paradigmatic example, with which to better understand their dynamics and mutations in other societies. With this project, I do not only intend to advance European research regarding screen industries, I hope to make a contribution to cultural studies at large, thanks to a close collaboration with top American scholars in the field (at the University of California, Santa Barbara and the University of Southern California).

Keywords: s113 communication networks - media - information society,s311 cultural studies - cultural diversity,s305 visual arts,e112 social economics,creation process,cultural markets,popular culture,agents
Control of Streptococcus agalactiae virulence genes via peptide-based cell to cell communication (CELLCOM-GBS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

Quorum sensing (QS) is a bacterial cell-to-cell communication process to control gene expression at population level. Recently, a new QS mechanism was described in streptococci. It involves a transcriptional regulator of the Rgg family and a small hydrophobic peptide (SHP), acting as a signaling molecule. The interaction between SHP and Rgg allows Rgg to control the expression of its target genes. One rgg/shp locus is present in Streptococcus agalactiae (Group B Streptococci), a commensal bacterium in humans, but also a leading cause of devastating infections in newborns and immunocompromised adults. Previously, another team described that Rgg is involved in the regulation of several virulence factors in GBS strain 6313; however, these studies were performed in nutritional rich conditions that are non-optimal for SHP-dependant Rgg activity, and its role in virulence was not addressed. Consequently, we hypothesize that Rgg relevance in GBS pathogeny has been underestimated. Our preliminary results showed that Rgg/SHP system is active in GBS strain NEM316, a newborn isolate. In addition, we found a growth condition that allows high-expression of Rgg/SHP system. The secretome of strain NEM316 and an isogenic rgg-deleted mutant was compared by a label-free proteomic approach. We identified one new target, a secreted protein with a putative transglutaminase (TG) function. This is encoded by all GBS strains sequenced up to now. Virulence experiments showed the implication of the Rgg/SHP system in the full virulence of GBS. The aim of this project will be to better understand this cell-to-cell communication mechanism and clarify its role in GBS pathogenesis. We will also study the function of the already identified target, in vitro and in vivo. Lastly, we will identify new Rgg/SHP targets. We hope that the results obtained will increase the understanding of pathogeny of GBS, opening possible novel approaches to decrease its virulence.

Keywords: l607 microbiology,l101 molecular biology and interactions,l203 proteomics,l307 cell signalling and cellular interactions,quorum sensing,streptococci,transcriptional regulation
Host target identification of anti-virulence drugs (TARGID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 192622.2
EU funding (EUR): 192622.2
Participants: 1
Project status: CLOSED

While short course chemotherapy for drug-susceptible tuberculosis (TB) remains effective, it is relatively inefficient by modern pharmaceutical standards and universally menaced by the dissemination of multidrug-resistant (MDR), extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (M.tb) and synergy with the HIV/AIDS pandemic. Since one third of the world’s population is latently infected with M.tb, successful anti-TB drugs must be able to eliminate persistent bacilli from the reservoir, which makes TB therapy more challenging. Most of the current antibiotics typically kill M.tb rather than targeting bacterial systems important in the virulence of the bacteria and manipulation of the host-specific biochemical pathways. Whereas normally the host immune system is able to destroy invading bacilli, M.tb developed a wide palette of strategies to avoid bactericidal host responses. The major and most studied virulence mechanism of the tuberculosis pathogen is the ESX-1 system, a type VII secretion system which clearly plays an important role in the pathogenicity and the host-pathogen interaction. The ESX-1 system modulates the host defence through different ways like phagosome maturation arrest, inhibition of TLR signalling in macrophages, macrophage apoptosis induction, and interaction with laminin. The here proposed project forms part of a multidisciplinary anti-virulence drug discovery program focusing on the identification of important host cell signalling pathways that are involved in the pathogenesis, entry and intracellular survival of M.tb. Anti-virulence drugs inhibit bacterial targets that interfere with host cell defence pathways during infection or block host signalling pathways modulated by the bacteria, thus defending the host from the pathogen. This novel strategy of anti-virulence drug discovery is a potential alternative to antibiotics, which may be used in combination therapies to shorten TB treatment and prevent resistance.

Keywords: tuberculosis,anit-virulence drug,esx-1,host cell signalling,host-pathogen interaction,signal transduction,type vii secretion system
Language policy and linguistic justice in the European Union (LAPO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

The goal of our project is address the question of the distributive consequences of a change in the current EU language regime and to estimate them using data contained in the Adult Education Survey (AES), published by Eurostat in 2011. The first aim of the project LAPO is to explore whether a correlation between skills in a foreign language and other socio-economic variables can be established. More specifically, I address the following questions: how would a decrease in the number of official EU languages affect those who have a relatively low income compared to those who have a high income? How would it impact on the most educated individuals as opposed to the least educated ones? Would it disadvantage unemployed people more than people with an occupation? What differences can be observed across European countries in this respect? Our hypothesis is that language policies do have significant distributional impacts among countries and also among social groups, and that a reduction in the number of official languages or a reduction of the domains of use of some of the current official languages would disadvantage not only (and quite obviously) some countries, but would also be significantly detrimental to some social groups more than others. The second aim of this project is to explore the relationship between the type of occupation of European citizens, the economic sector in which they work and their linguistic skills and frequency of use of languages. I test the hypothesis that language competence significantly varies among occupation groups and economic sectors. Our study could be used to implement a more effective and fair language policy. First, I clarify which "occupation groups" would be disadvantaged by a change of the EU language regime. Second, it can help decision makers to allocate resources better, that is, providing more multilingual information (through translation and interpreting) in EU policy areas in which it is more urgent and relevant.

Keywords: s208 use of language,s207 acquisition and knowledge of language,e114 public administration - public economics,language policy and planning,language economics,multilingualism
Emerging infectious disease and population genetic structure (EIDPOP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Emerging infectious diseases are increasing worldwide, and have been implicated in population declines and species extinctions. We know that diseases can cause major changes to the genetic composition of host populations through selection and population declines, and in turn that such changes can influence the impact of disease on host populations. We also know that diseases can lead to changes in mate choice behaviour which can alter the population structure, again influencing the impact of disease - yet this has as yet received little attention. This proposal focuses on investigating the interactions between genes, behaviour, and disease, using a model system of Ranavirus (an EU notifiable disease known to be contributing to amphibian declines) in common frogs (Rana temporaria) in the UK. Transcriptomics will be used to gain an understanding of which genes are involved in the host response in the wild to Ranavirus, and controlled laboratory experiments will be used to determine whether these genes are also involved in offspring survivorship. Sequencing of candidate genes in individuals will be used to examine how genotype influences parental mate choice, and the resulting fitness consequences of mate choice on the offspring will be determined. Furthermore, this proposal provides the foundations for a long-term study on how host genotype changes throughout the progression of an epidemic. As such, this proposal addresses fundamental scientific questions relating to the impact of disease on populations, which is critical for our understanding of the wider evolutionary impacts of disease and so for improving our ability to manage such emerging diseases. In addition, this research will directly improve our knowledge of an important driver of global amphibian declines

Keywords: l202 transcriptomics,l606 immunogenetics,l805 conservation biology - ecology - genetics,l802 population biology - population dynamics - population genetics