Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression (ElectroGene)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2025-01-31
Duration (months): 75.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, thus linking diagnosis and therapy to block disease onset (prevention). ElectroGene design principles and devices will be validated in proof-of-concept preclinical studies for the treatment of diabetes.
Assessing microbial impact on trapping of radioactive contaminants from groundwaters by minerals (MITRad)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

The European Union supports several directives to protect groundwater from hazardous contaminants, including radionuclides. This project aims to increase understanding of uranium retention pathways in calcite mediated by iron sulphides and microorganisms in a deep crystalline rock-groundwater system. This will be achieved by implementing a comprehensive experimental approach involving various isotope proxies in minerals and secondary, deep groundwaters, integration with microbiological studies, spectroscopic techniques, and hydrogeochemical modelling. The results will help to decipher microbial signatures in modern and ancient redox processes and microbial impact on the mobility of trace elements in groundwaters in the vicinity of the future granitic type nuclear repositories.

Keywords: groundwater,radioactive contaminants,uranium,calcite,iron sulphide,microorganisms,spent nuclear fuel
BUILD UP Skills to Business (BUStoB)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands
Call: Construction skills (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2018-08-31
Duration (months): 42.0
Total project cost (EUR): 1385775.8
EU funding (EUR): 1385775.8
Participants: 11
Project status: CLOSED

This project is directed towards establishing and upgrading large-scale qualification and training schemes in the Netherlands for craftsmen and other on-site workers, in the continuation of the BUILD Up Skills Initiative. The proposed project uses the results of the IEE-projects and is a necessary step towards closing the gap between existing and needed skills for craftsmen and building workers in the Netherlands in the respect of meeting the 2020 energy objectives.The main objective of the project is to develop and pilot missing training materials on EQF-levels 2 - 4 based on the future-ready qualification schemes developed in BUILD UP Skills Pillar II. Secondary objective is to construct short skill measurement tests which enables the prevention of mistakes made by unconsciously incompetent workers, the detection of skills gaps and supply of industry relevant upskilling advice to craftsmen and building workers.Tertiary objective is to organise regional pilots in which we focus on implementation and evaluation of the developed materials and regional capacity building. We will support regional training partnerships with train-the-trainer sessions, regional labour market intelligence and implementing the developed trainings and assessments in practice in regional building and/or renovation projects. As results of the project the following will be achieved: • Increase the skills of 3000 craftsmen by the end of year 2018 • Increase in RES-production of 11 GWh/year • Decrease of energy consumption of 69 GWh/year (EE) • Increase the employability of the building workforce with 3000 of which at least 5% women • Increase in investments in innovative sustainable energy technologies with €42.7 million • Acquired additional funding of €1.000.000,- to sustain the action

Keywords: this proposal builds on the successes of build up skills pillars 1 and 2 in the netherlands
European Researchers' Night We Create Science and History (WeCreate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 170425.0
EU funding (EUR): 160000.0
Participants: 1
Project status: CLOSED

We Create Science and History is a project that brings together researchers from all universities in West Pomeranian region. With the help of cooperating institutions acting for science and culture heritage, we will organize over 500 attractions for public coherent with assumption of WP 1 and 2 to expose researchers that stand directly behind researchers responsible for the most inspirational innovations in science that not only a local community have had benefited from. Through their work and inventions, they also create history and cultural heritage. In order to make scientific themes interesting and accessible for the public, and to encourage public to participate in the project at the same time, we will create a interactive Map of Science and Culture Heritage of Szczecin and region including: all universities and science centers, historical parks, squares and urban complexes. Most of locations shown on a virtual map will became open to the public and various number of interactive activities will be executed in accordance and coherence with the venue specifics. All those activities are being conceived as to address all categories of the public at large whichever their social status and background. Visitors will be able to find information on how science and technology expertise and information is being used for the city and province improvement. During the ERN events the scientists from universities will meet with the public in person to explain all key features of the invention, and talk about their work and achievements specially funding by EU framework programmes. The main goal of this project is to enhance researchers' public recognition, the opportunity of discovering in an attractive form a direct impact and its importance of researchers work on every aspect of the improvements of the environment that surround us, as well as to inspire and enlarge the understanding of the attractiveness of pursuing a one's career as a researcher.

Keywords: researchers are among us,science creators,we learn from each other,everyone can be a researchers,europe cares for researchers,scientists have the best works in the world,science is passion
Innovating Hessian SMEs towards Europe (InnoHessen2Europe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 156563.75
EU funding (EUR): 156563.75
Participants: 5
Project status: CLOSED

With this proposal the coordinator of the EEN Hessen consortium, Hessen Trade & Invest GmbH (HTAI), participates as a sole partner in the Consultation of Enterprise Europe Network partners on the work programme for 2020-2021 Horizon 2020 activities. HTAI will implement the action on services enhancing the innovation management capacities of SMEs under the H2020 programmes for specific activities in the context of innovation support and European Innovation Council (EIC) pilot. SME beneficiaries of EIC Pilot will be supported with dedicated Key Account Management (KAM) services. EEN Hessen will assess their gaps and challenges in the innovation process, identify and propose a suitable coach, facilitate the interaction between the coach and the SME and respond to further needs by additional support measures. The overall aim is to enable those companies to conduct their innovation projects successfully and thus to contribute to their commercial growth. Other SMEs with significant innovation activities and a high potential for international growth will be supported in the separate process of Enhancing the Innovation Management Capacity (EIMC). EEN Hessen will identify suitable companies in Hessen and motivate them to use the EIMC service, assess their gaps and needs, develop an appropriate action plan and facilitate its implementation. With these activities, complemented by a wide range of further EEN services along the client journey, HTAI strives to increase the competitiveness of Hessian SMEs and strengthen their ability to operate successfully in the European Single Market and outside, thus contributing to the aims of the Europe 2020 strategy. The action will be conducted by the EEN Hessen innovation experts, all senior staff experienced in innovation management. They will use the Innovation Health Check by Enterprise Ireland as a CEN/TS 16555-1 conform assessment tool.

Keywords: innovation support,innovation management,kam services for sme beneficiaries of eic pilot,enhancing innovation management capacities of smes in hessen
Support to the Vice-Presidents of the ERC Scientific Council 2017 (ERC VP CSA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Denmark
Call: Support to the Vice-Chairs (H2020-IBA-ERC-VPRES-SUP-17, 2017)
Start date: 2017-01-01
End date: 2017-12-31
Duration (months): 12.0
Total project cost (EUR): 289928.0
EU funding (EUR): 289928.0
Participants: 1
Project status: CLOSED

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees the ERC's scientific management and the implementation of its Work Programme. This project aims to support the ERC Vice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2017. This project will provide local administrative and advisory support to the three ERC Vice-Presidents. The staff supported by this project will provide analysis of the output of the ERC and the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment. The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon 2020.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liaison with the erc executive agency
Chemical proteome mining for functional annotation of disease relevant proteins (CHEMMINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1936250.0
EU funding (EUR): 1936250.0
Participants: 1
Project status: CLOSED

Genome sequencing projects have provided unique insights into the cellular inventory of genes and their corresponding protein products. Despite this success, a large fraction of cellular proteins remains functionally uncharacterized. Their annotation represents a major challenge for contemporary research, reaching beyond the power of bioinformatic sequence similarity searches. Thus multidisciplinary strategies consolidating chemical and biological methods are required to close this gap. We here approach the challenge by two chemical proteomic platforms that focus on disease relevant sub-fractions of the uncharacterized proteome. The first platform utilizes functionalized cofactors that exploit cognate cellular uptake systems and report specific binding of large enzyme families. The molecules will be applied to mine cellular proteomes for unknown family members with crucial roles in diseases and assign their function. The second platform exploits phosphoaspartate as an important disease-related post-translational modification. Due to low stability, this transient modification currently escapes detection by established proteomic procedures. Moreover, little is known about the enzymes that catalyze aspartate phosphorylation. We here use specific nucleophilic traps that convert phosphoaspartate into stable modifications suitable for analytic detection. In addition, the complement of currently unknown phosphodonor proteins will be identified with customized tools. With these platforms we aim to functionally annotate sub-fractions of the uncharacterized proteome and utilize our tools for the identification of new drug targets by comparative analysis of healthy and diseased cells. Finally, we apply the camouflaged molecular design strategy in the synthesis of compound libraries to screen for candidate inhibitors against selected, disease-modulating targets. The previous record of my group in chemical proteomics provides a strong basis to achieve these challenging goals.

Keywords: chemical proteomics,enzyme function,cofactors,probes,synthesis,post translational modification,phosphorylation,mass spectrometry,biological activity
Differentiated health impacts of primary and secondary ultrafine particles (Health1UP2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-07
End date: 2019-09-06
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Exposure to particulate matter (PM) has been linked to negative health effects. Traditionally attributed to PM<10µm and<2.5µm, negative health effects may be enhanced with decreasing particle size, suggesting that ultrafine particles (UFP, PM<0.1µm) might be responsible for what has previously been attributed to larger size fractions of PM. According to their origin, UFP can be primary (directly emitted to the atmosphere) or secondary (formed in the atmosphere from precursor gaseous pollutants). In central European cities, UFP particle concentrations (N) are mainly affected by road traffic emissions, as evidenced by the parallel variation of N and Black Carbon (BC, traffic tracer) concentrations. However, in European regions with high insolation, the maximum N is observed at midday (when BC is low) due to photochemical nucleation. A methodology developed by Rodriguez et al. (2007) allows the quantification of the primary (N1) and the secondary (N2) contribution to total N. Depending on origin and size, UFP may differently affect human health but no study has yet tackled this key issue. Moreover, there are currently no legal ambient standards for UFP. The main objectives of Health1UP2 (Differentiated health impacts of primary and secondary ultrafine particles) are (i) to uncover the differences in N1 and N2 in the cities of London (UK), Barcelona (Spain), Zurich (Switzerland) and Helsinki (Finland), based on long time-series of size-segregated UFP and BC data, and (ii) to determine the health impacts (mortality and hospital admissions as outcomes) of the exposure to differentiated N1 and N2 in different size-ranges in these cities.This research requires an international collaboration, since different meteorological conditions, pollutant emissions and other parameters influence divergently on N1 and N2. The results of this work will serve as indication to the corresponding authorities of which pollutants should be included in future EU legislation about air quality.

Keywords: ultrafine particles,primary particles,secondary particles,time series study,black carbon,particulate matter,environmental epidemiology,hospital admissions,mortalily
Analytical and Characterisation Excellence in nanomaterial risk assessment: A tiered approach (ACEnano)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Germany,Spain,Germany,Germany,Belgium,Switzerland,Sweden,Korea, Republic of,Sweden,Switzerland,China,Switzerland,Switzerland,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Analytical techniques and tools in support of nanomaterial risk assessment (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 10761803.75
EU funding (EUR): 7000000.0
Participants: 32
Project status: CLOSED

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual “toolbox” that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.

Keywords: nanomaterials,fate,exposure,transformations,ontology,hazard,physicochemical properties,descriptors,toolbox,safe by design