Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tanycyte/arcuate Neuron communications in the regulation of energy balance (TANGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The escalating pandemic of obesity and type-2 diabetes represents one of the most pressing and costly biomedical challenges confronting modern society. The brain's impaired ability to sense and respond to variations in energy homeostasis is increasingly recognized as playing a role in the pathophysiology of these disorders. By sensing the nutritional status of the organism, distinct neural cell populations –including neurons and glia present in the arcuate nucleus of the hypothalamus (ARH)– tightly regulate energy balance. In the last decade, it has become clear that tanycytes –hypothalamic glial cells lining the bottom of the third ventricle and sending a single basal process into the ARH– are also able to detect variations of nutrient and hormone levels. Henceforth described as “sensors” of the metabolic state, tanycytes would then modulate neuronal function in order to regulate energy balance. However, the mechanisms underlying the communication between tanycytes and ARH neurons in the context of metabolism remain largely unexamined. The overall objective of this project is to elucidate the molecular, structural and functional organization of tanycyte/ARH neuron communications, and their involvement in the regulation of energy balance. A multidisciplinary approach including neuroanatomy, molecular biology, and physiology will be implemented to achieve four specific aims: 1) To decipher the genetic and neuroanatomical features of tanycyte/ARH neuron metabolic units 2) To ascertain the impact of tanycyte Annexin A1 on ARH neuronal function 3) To uncover the role of tanycyte local translation in specific tanycyte/neuron communications 4) To reveal the impact of tanycyte glucose-sensing on ARH neuronal gene expression The elucidation of tanycyte/neuron communications will be essential to explain the regulation of food intake and to allow the development of new therapeutic strategies for obesity and associated metabolic syndromes.

Keywords: energy balance,hypothalamus,tanycytes,cel to cell communication,annexin a1,local translation,transcriptomics
Pilot Action for Securing a Sustainable European Next Generation of Efficient RE-free magnets (PASSENGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Spain,Germany,Austria,Germany,Germany,Italy,Italy,Italy,Spain,Italy,Italy,Germany,Spain,Slovenia,Slovenia,Greece,France,United Kingdom
Call: Raw materials innovation actions: exploration and Earth observation in support of sustainable mining (H2020-SC5-2020-2, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 11309888.75
EU funding (EUR): 8903085.9
Participants: 22
Project status: SIGNED

PASSENGER addresses to the topic CE-SC5-10-2020 on raw materials innovation under subtopic d) Pilots on substitution of critical and scarce raw materials (2020). PASSENGER aims to develop innovative pilots to address an aspect of high economical, technological, social and environmental relevance: a solution for the EU dependency on rare-earths (REs) for permanent magnets (PMs), avoiding bottlenecks in the material supply-chain and diminishing the environmental impact. Considering the importance of PMs in present and emerging technologies, PASSENGER will develop up scaled alternatives based on widely available resources and innovative technologies. PASSENGER has a clear industrial orientation involving key end users and SMEs/LEs (13 industrial partners) from 8 EU countries. PASSENGER will develop a sustainable substitution pilot in PMs subdivided in 8 innovative pilot activities covering the complete value chain to finish at TRL7 and to guarantee implementation across the EU after the project is finished. The choice of PMs is based on realistic (envisioned up-scaling, low cost and environmental impact) projects results and patents (proven at TRL 4-5) achieved by the partners in successful EU projects: Improved Strontium ferrite (Sr-ferrite), Manganese-Aluminum-Carbon (MnAlC) and related technologies. These RE-free PM alternatives will substitute bonded NdDyFeB-magnets, which are constituted by diverse critical raw materials: REs (Nd and Dy, and Pr in some compositions); Metal (Cobalt). Electromobility has been chosen as a main key-driving sector with three application areas: Class 1: e-scooter; Class 2: e-bikes and e-motorbikes; Class 3: e-cars. The project will be done under premises of sustainability and reduced environmental impact, including Standardisation activities, Life Cycle Assessment (LCA) and Life Cycle Cost (LCC) analysis, recyclability and social-life cycle assessment of PASSENGER’s products and technologies.

Keywords: permanent magnets,electromobility
Holography under extreme conditions (ExHolo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Understanding the properties of extreme phases of nuclear matter is one of the major challenges in theoretical physics today. Matter at high temperatures dominated the first microsecond of the early universe and is nowadays produced in relativistic heavy ion collisions in the form of the Quark-Gluon Plasma (QGP). Systematic experimental studies at the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider (RHIC) support the picture of the QGP as an almost perfect fluid but the mechanism for its fast emergence from collisions of hadronic matter remains a puzzle to this day. Another surprising observation was the liquid-like behavior of small systems emerging from proton-proton or proton-lead collisions and the absence of jet quenching which is considered to be a crucial probe characterizing the strongly-coupled QGP. In this proposal I aim at finding a dynamical picture of the thermalisation of out-of-equilibrium matter into hydrodynamic fields by making use of a powerful new framework for studying strongly-coupled dynamical systems: the gauge/gravity duality. It allows to map the strongly-coupled gauge theory dynamics of colliding ions to the collision of gravitational shockwaves which is amenable to numerical general relativity. This offers a unique real-time approach to study the dynamics of hot matter out-of-equilibrium, which I will exploit to tackle two essential problems: i) out-of-equilibrium emergence of collectivity and the fast thermalization of the QGP; ii) system-size dependence of the momentum broadening by jets; This project is inter-disciplinary as it involves applying numerical gravity via holography to the physics of matter at extreme conditions, using the most advanced High-Performance-Computing techniques which I am an expert in. The understanding of the thermalisation scale, of jet quenching and the description of pre-flow, is essential for a determination of the QGP properties of heavy-ion collisions.

Keywords: gauge,gravity duality,holography,thermalization,out of equilibrium qcd,heavy ion collisions
Personalized, bio-engineered skin grafts for the permanent treatment of skin defects (denovoSkin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-12-31
Duration (months): 27.0
Total project cost (EUR): 3571237.5
EU funding (EUR): 2499866.25
Participants: 1
Project status: CLOSED

Every year in the world, more than 50M patients suffer from skin defects (e.g. burns, excision, etc.) and need surgical intervention to restore skin function. Standard of care, skin autografting, very often leaves these patients with scars. Scars are permanent and disfiguring, and can also be painful and highly debilitating. Indeed, they may also impair movement and growth, and require several follow-up surgeries, intense homecare and psychosocial rehabilitation. Hence, scars significantly affect patient’s quality of life, along with the economic burden for the health-care system. Furthermore, in the case of large wounds, donor site shortage represents a real clinical issue. denovoSkin™ is a patented, personalized, autologous bio-engineered human skin graft classified as Advanced Therapy Medical Product (ATMP). It is engineered in large quantities starting-off from a stamp-sized skin biopsy of the patient, thus solving the donor site shortage issue. Moreover, because of its dermo-epidermal structure, denovoSkin™ leads to minimal scarrring after transplantation. Its outstanding performance could considerably reduce or even avoids further corrective interventions, allowing for considerable savings in terms of costs. denovoSkin™ is also granted with Orphan Drug Designation for the treatment of burns by Swissmedic, EMA and FDA. So far, more than €17.5M have been invested over the last 16 years of research into the development and the clinical testing of denovoSkin™. To have denovoSkin™ fully projected at a European and global level we need a further investment of €3.57M to automate its production, de-risking the entire denovoSkin™ project by assuring a real delivery to patients worldwide while providing optimal logistics and quality of product. The proposed work in Phase 2 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of denovoSkin™ and its market uptake.

Keywords: skin grafts,autologous,bio engineered skin,tissue engineering,scarring,donor shortage,burns
Smart Ceramic Hollow Fibers for Energy Efficient Gas and Vapour Sorption (SmartSorp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The aim of this project is to develop a novel ceramic hollow fiber adsorption system for high throughput, energy efficient separation and purification of gases/ vapours. Current adsorption technologies are grossly energy inefficient due to waste heat generation and long regeneration times. Therefore, it is important to develop new energy efficient, smart functional materials in order to meet society’s future energy demands. Functional hollow fibers with smart characteristics (such as self-regulated heating and regeneration of the adsorbent bed) have the potential to meet these challenges, and compact systems could be formed that also exhibit low pressure drop, no adsorbent bed settling and channelling, and have a low thermal mass for rapid regeneration of the adsorbent layer. The novel hollow fiber will consist of a thin film zeolite inner layer for adsorption of target species, while the outer layer is formed from a perovskite-type Lanthanum doped BaTiO3 ceramic with positive temperature coefficient of resistance (PTCR) characteristics. The PTCR layer provides inherent temperature control, imparting self-regulating and self-limited Ohmic (Joule) heating with thermal energy directed onto the inner adsorbent layer in order to regenerate the system for the next process cycle. This is a highly multidisciplinary project encompassing the formation of electro-ceramic hollow fibers from wet spinning techniques, zeolite deposition chemistry, and industrial engineering. The MSC-IF researcher will work within the Swiss Federal Institute for Materials Research (EMPA) in the High Performance Ceramics Group, where he will develop expertise in ceramic processing and extrusion. A prototype ceramic hollow fiber, gas purification system will be developed and benchmarked against conventional packed-bed technology, during a secondment phase to NanoPurification Solutions Ltd (UK), a manufacturer of industrial gas separation technology.

Keywords: ceramic hollow fibers,smart materials,gas separation and purification,energy efficiency
Doctoral programme for innovators with X-rays and neutrons (InnovaXN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 6508800.0
EU funding (EUR): 3254400.0
Participants: 1
Project status: SIGNED

Researchers trained in advanced materials characterisation and capable of exploiting the facilties available at research infrastructures (RIs) are needed to bridge the knowledge gap between Europe’s world-leading RIs and industry. These select individuals should be highly-skilled entrepreneurs and communicators in addition to being innovative researchers. The InnovaXN programme aims to create such uniquely-skilled ambassadors to industry by recruiting and training 40 Early-Stage Researchers (ESRs) who will carry out research on projects defined and realised in close collaboration with industry. The programme will link the ESRF and ILL RIs with industry through 40 research projects. The subject of these projects will comprise multiple research fields from the vast range of subjects of interest to industry that could be enhanced by studies at the RIs such as drug discovery and health, energy materials, environmental science, food science and micro-electronics. InnovaXN will be a five-year programme. Research projects will be harvested through an open ideation and codesign procedure with industry. Two recruitment calls will be spaced twelve months apart. The duration of each ESR training period will typically be 36 months, with registration of the ESRs at Université Grenoble Alpes (UGA), a partner to the project, or other collaborating European universities. InnovaXN aims to recruit the best candidates from a worldwide student base. InnovaXN is open to students from a wide range of disciplines including chemistry, life sciences (biochemistry, medicine), materials science, engineering, environmental science and physics. The ESRs will receive employment contracts at the ESRF or the ILL (each will recruit half of the students). The ESRs will be hosted in Grenoble at the EPN-Campus site for most of the duration of their research but for a period of secondment to the site of the industry partner of at least three months to gain experience of working in industry.

Keywords: innovation,industry,research infrastructure,synchrotron x rays,neutrons
Joint Dynamics During Infant Learning (JDIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Infants spend most of their waking time interacting with their caregivers, and the mechanisms through which these dynamic social exchanges shape the development of sub-personal processes such as attention and learning remain mysterious. Most of our understanding of how the brain subserves early attention and learning has come from studies that viewed infants as relatively passive recipient of information, and studied individual brains in isolation. Correspondingly, we know very little about the neural substrates of how information is shared between caregivers and infants during learning interactions. The aim of this project is to shed unprecedented light on how dynamic social interactions affect attention and learning during infancy. I will build both on my own recent research, that has shown that internal metacognitive monitoring and epistemic requests from the infant shape social interactions and learning more than had previously been thought, and combine this approach - that views the infant as an active component of early social interactions - with innovative research by my supervisor that provides the possibility to record brain activity from infants and their caregivers simultaneously while they are interacting, and to analyze them with specific tools that allow a fine description of the dynamics of these interaction. Combining these two approaches will provide invaluable insight into the mechanisms involved during early learning in social contexts. Our findings will have substantial implications for theories of development, as well as diagnostic and educational practices. More specifically, increasing our understanding of the complex dynamics between infants and their social partners is essential for: i) enriching developmental theory; ii) developing new techniques to optimize learning and iii) understanding the mechanisms that give rise to developmental delays.

Keywords: joint attention,dual eeg,infant learning,social learning,active learning,word learning,pre verbal communication,attentional dynamics,communicative dynamics
Convergence of Electronics and Photonics Technologies for Enabling Terahertz Applications (CELTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Ireland,Italy,Italy,Finland,Poland,Sweden,Czechia,Czechia,Netherlands,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3785419.68
EU funding (EUR): 3785419.6799999997
Participants: 13
Project status: CLOSED

CELTA: Convergence of Electronics and Photonics Technologies for Enabling Terahertz Applications aims to produce the next generation of researchers who will enable Europe to take a leading role in the multidisciplinary area of utilizing Terahertz technology for applications involving components and complete systems for sensing, instrumentation, imaging, spectroscopy, and communications. All these technologies are key to tackle important solutions in a large number of focus areas relevant for the societal challenges identified in the Horizon2020 work programme. To achieve this objective, CELTA is comprised of eleven leading research institutions and assembled a comprehensive research training programme for all the fifteen early stage researchers (ESRs). CELTA integrates multidisciplinary scientific expertise, complementary skills, and experience working in academia and industry to empower ESRs to work in interdisciplinary teams, integrate their activities, share expertise, and promote a vision of a converged co-design and common engineering language between electronics and photonics for Terahertz technologies. Therefore, CELTA will introduce the strategy of converged electronics and photonics co-design in its research program and makes a special effort on establishing a common engineering language in its training program across the electronics, photonics and applications disciplines. We believe this common engineering language and converged co-design is mandatory to make the next logical step towards efficient and innovation solutions that can reach the market. The detailed compendium of lectures on state-of-the art technology, soft skills and entrepreneurship is accompanied by a research programme that focuses on THz key technologies. CELTA ESRs will develop three demonstrators: beam steering technology for communication applications, a photonic vector analyser for spectroscopy and materials characterization, and a THz imager for sensing applications.

Keywords: terahertz,photonics,imaging,electronics
Quantum Unique Ergodicity and Random Waves on Graphs (QUERWG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The proposal aims to address two important conjectures of Quantum Chaos, Quantum Unique Ergodicity and the Random Wave hypothesis, via the analysis of eigenfunctions of the Laplacian on discrete graphs. It will provide a better understanding of two difficult problems of mathematical physics through an original approach, while developing spectral theory on graphs. The latter has a strong potential of applications in the study of networks, whose understanding is of great importance in the modern world. The expertise of the experienced researcher on analysis on graphs will be ideally complemented by the quantum chaos and ergodic theory specialists of the University of Bristol, to ensure the success of this project.

Keywords: quantum unique ergodicity,random waves,eigenfunctions of the laplacian,discrete graphs