Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EMBRYON - Develop and commercialize a highly innovative diagnostic-imaging product, improving success rates in the Assisted Reproduction IVF sector (EMBRYON)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Infertility is a heavy social issue,experienced by nearly one in six couples during reproductive lifetime. In Vitro Fertilization (IVF) is growing 8-10% p.a.,to 1.5 million therapy cycles and 7.5 billion dollars in 2013. Despite stressful and costly procedures,IVF success rate is low (15-20% births/cycle),leaving big opportunities for innovation and process optimization. EMBRYON introduces to IVF clinics and specialists a last-generation diagnostic-imaging system,favoring better outcomes through deeper,smarter analysis of clinical images. It merges tailored image-processing software and algorithms,patented by ACS,with a high-end commercial IVF microscope.A prototype is under validation with top clinics in Italy and Switzerland,supported by Nikon Instruments (global leader in IVF microscopy). EMBRYON improves the key success factor of any IVF procedure:the identification of 1-2 embryos with best “pregnancy potential” to be transferred in utero,amongst 5-10 generated in vitro. EMBRYON’s precision is double than current handcrafted approaches,favoring higher success rates. It is safer (100% not invasive),thus simpler to certify and adopt,fully compliant with ethical regulation,easier to use (no change to lab procedures) and cheaper than similar products. Key innovations 1. Automated deep scan of embryo shape,overcoming today’s subjective and approximate observations carried by the physician 2. Proprietary algorithms for the measurement of complex morphological patterns,strong predictors of potential Sales forecasts are 1200-1400 units (40-45 M€ gross revenues) by 2020 in Europe and US,favored by: - High reactivity of the IVF sector (scientists/patients) to validated solutions improving outcomes - Commercial partnership with a global IVF microscopy leader In Ph1 we’ll finalize and publish the ongoing clinical studies and make a deep market analysis for Europe-US In Ph2 we plan CE/FDA clearance,WW extension of patents,3 trials in Europe-US,set-up of newco and sales org

Keywords: assisted reproduction techniques,image analysis,fertility
Eastern Mediterranean Science and Technology Center of Excellence for Archaeology and Cultural Heritage (MedSTACH)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Cyprus,Greece,United Kingdom
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399625.0
EU funding (EUR): 399625.0
Participants: 6
Project status: CLOSED

This proposal aims to contribute to the transformation of Cyprus into a regional cultural heritage (CH) excellence hub, whereby technologically innovation and specialisation will have a prominent development role. To this end, key local public academic institutions and national policy makers / stakeholders are teaming with leading international institutions to lay the groundwork beneath an “Eastern Mediterranean Science and Technology Centre for Archaeology and Cultural heritage”, in short MedSTACH. MedSTACH’s mission and business strategy address Environmental Dimensions of Sustainable Growth, as defined by the Smart Specialisation Strategy for Cyprus (S3Cy), responding, in particular, to the need for protection, promotion and valorisation of the island’s unique CH capital. In addition, MedSTACH addresses all horizontal priorities of S3Cy, namely, Extended Innovation, Human Capital, Promotion of Cooperation, Enhancement of Extroversion, and Information Technologies, as well as Tourism, the major priority sector for Cyprus’s sustainable growth, and the secondary priority sector of Built Environment. In terms of R&I, the envisaged Centre’s activities will encompass the following Key Research Domains (KRDs) that cover multiple facets of archaeological enquiry and cultural heritage priorities: Heritage Exploration; Spatial Inference; Heritage Protection; Material Characterization; these KRDs will be supported by and provide feedback to the Heritage ICT Unit. The activities of the proposed Centre of Excellence on archaeology and CH will contribute to on-going efforts to overcome the present economic crisis in Cyprus, as well as to reconstruct and transform the island’s economy and society according to the strategic framework “Europe 2020”. The depth and breadth of the collective expertise of MedSTACH consortium partners offers the unique potential to overcome local barriers and excel in R&I while promoting smart specialisation and sustainable job creation

Keywords: heritage exploration,spatial inference,heritage protection,material characterization,heritage ict
Structuring Raw Scans (SemanticCity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-11-01
End date: 2020-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Many massive data sources now exist for large scale 3D measurements in the form of raw pointclouds or polygonal soups. Such raw data, however, have to be cleaned, consolidated, and semantically annotated before they can be consumed by downstream applications (e.g., augmented reality, procedural modeling, energy simulation, etc.). This manual step is a major processing bottleneck resulting in significant economic and efficiency costs. For example, state-of-the-art workflows in location-based services and urban planning industries easily take 2-3 man days to produce accurate semantic labels for small spaces (500-1500 sqm), or several man weeks for a few blocks of street (2-5 sqkm). This makes large-scale semantic annotations unfeasible, and hence, majority of the raw scan data archives remain under-utilized. The proposed "Proof-of-Concept" SemanticCity aims to pre-commercialize a novel software suite utilizing algorithms developed in course of the ERC-funded SmartGeometry project for automating generation of semantically structured models from raw 3D scans of cities to enable next generation augmented reality (AR), urban planning, and semantically tagged location-based services. SemanticCity, in partnership with a major European AR company, a large UK-based city developer, and London local councils, will address this challenge by automatically producing structured output directly from raw 3D measurements, reduce computation times from days/weeks to hours, and evaluate the structured output via the AR City app on multiple large-scale datasets. As case studies, we will work with governmental agencies and identified partner companies to meaningfully utilize their large archives of 3D measurements which are currently largely under-utilized.

Keywords: structure,range scans,3d acquisition,augmented reality,urban planning,semantics
How body relevance drives brain organization (RELEVANCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Belgium,Netherlands
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 8309114.0
EU funding (EUR): 8309114.0
Participants: 3
Project status: SIGNED

Social species, and specifically human and nonhuman primates, rely heavily on conspecifics for survival. Considerable time is spent watching each other’s behavior because this is often the most relevant source of information for preparing adaptive social responses. The project RELEVANCE aims to understand how the brain evolved special structures to process highly relevant social stimuli like bodies and to reveal how social vision sustains adaptive behaviour. This requires a novel way of thinking about biological information processing, currently among the brains’ most distinctive and least understood characteristic that accounts for the biggest difference between brains and computers. The project will develop a mechanistic and computational understanding of the visual processing of bodies and interactions and show how this processing sustains higher abilities such as understanding intention, action and emotion. Relevance will accomplish this by integrating advanced methods from multiple disciplines: psychophysics and high-field functional imaging in combination with virtual reality and neural stimulation in humans; electrophysiology with optogenetics and laminar recordings in monkeys. Crosstalk between human and monkey methods will establish homologies between the species, revealing cornerstones of the theory. In a radical departure from current practice, we will develop novel deep neural network models that unify the data. These models will not only capture detailed mechanisms of neural processing of complex social stimuli and its dynamics, but also reproduce the modulation of brain activity during active behavior. RELEVANCE will reveal novel ways of understanding and diagnosing social communication deficits in neuropsychiatry, and suggest novel hypotheses about their genetic basis. It will motivate novel principles and architectures for processing of socially relevant information in computer and robotic systems.

Keywords: social vision,body representation,high level vision,neural modeling
Epigenetic Regulation in Acinetobacter baumannii (ERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

Gene expression in bacteria is regulated by a multitude of mechanisms to facilitate adaptation to changing environmental conditions and during infection, which is key to their evolutionary success. To ensure that genes are only expressed in the right place and at the right time, access of transcription factors to promoters that drive gene expression can be controlled by DNA binding proteins and DNA methylation. DNA methylation is a seemingly simple, yet powerful mechanism mediated by methyltransferases (MTases) of restriction-modification (R-M) systems or orphan MTases which methylate specific genomic sites and can modulate transcription factor binding thereby regulating gene expression. Although epigenetic regulation is widespread in bacteria, the exact regulatory mechanisms are often unknown. Epigenetic regulation is often found in pathogenic bacteria and it was shown that methylation can affect their virulence, biofilm formation and other important features. In this project, we will use the WHO priority pathogen Acinetobacter baumannii as a model to decipher epigenetic regulation. A. baumannii strains encode from one to ten different MTases and it was shown that the deletion of the most conserved A. baumannii MTase decreased motility and virulence suggesting a gene regulatory role for this MTase. This project will investigate the impact of MTases on epigenetic gene regulation of A. baumannii using bioinformatics and functional genomic approaches to uncover their role for A. baumannii biology. Considering regulatory MTases as a potential drug target, understanding epigenetics would inform new approaches for the treatment of A. baumannii infections. Additionally, the distribution of R-M system genes in different strains of bacteria can be useful in phage therapy development to create the phage resistant to the R-M systems of the most dangerous strains.

Keywords: dna methyltransferase,transcription regulation,acinetobacter baumannii,comparative genomics
FLExibilize combined cycle power plant through power-to-X solutions using non-CONventional FUels (FLEXnCONFU)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Spain,Italy,Belgium,Belgium,Belgium,Sweden,Greece,Belgium,Greece,France,France,Netherlands,Netherlands,United Kingdom,Portugal,Portugal
Call: Integrated solutions for flexible operation of fossil fuel power plants through power-to-X-to-power and/or energy storage (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 12555440.0
EU funding (EUR): 9887141.39
Participants: 21
Project status: SIGNED

Natural gas (NG) fired Combined Cycle (CC) power plants are currently considered the most flexible power plants to operate in the EU grid to facilitate RES penetration. They changed their role in the EU electric market from the backbone of EU electrical grid to providing most of regulation services necessary to increase the share of non-programmable renewable sources into the electrical grid. In order to enhance their flexibility and also start to sell flexibility/ancillary services (also considering potential virtual aggregation), GT Original Equipment Manufacturers (OEMs) and Utilities are investigating new strategies and technologies for power flexibility, also considering that a “fuel switch” is close foreseen from coal to NG among most used fossil based dispatchable power plants and that the role of CC will be of “RES best friends” at least up to 2030. In this sense reducing their emission is also a strong need of GT R&D panorama promoting the exploitation of different fuels than Natural gas only. FLEXnCONFU aims to demonstrate at TRL7 in Ribatejo EDPP CC Power Plant a Power-to-gas-to-power (P2G2P) solution that will enhance CC flexibility (thus enabling them to provide grid flexibility services and getting higher revenues), reduce their NG consumption and therefore their related emission. The P2G2P system will be based on a Power-to-Hydrogen solution developed by HYGS+ICI, while a Power-to-ammonia-to-power solution developed by PROTON and ICI will be demonstrated in a properly modified microgas turbine operating in a UNIGE laboratory within the Savona Smart Microgrid (TRL6). The P2G2P solution will be directly controlled by a grid driven/responsive management system developed by MAS. GT combustion acceptability of different NG/H2/NH3 mixtures will be studied in CU labs. FLEXnCONFU will be a demonstration to market project and upscale and replication of the demonstrate P2H/P2A will be studied (in ENGIE and TP CC plants) and properly promoted by ETN.

Keywords: combined cycle,flexibility,power to x to power,power to hydrogen,power to ammonia,hydrogen and ammonia combustion,emission reduction,small ammonia reactor,power plant
MicroLED Pixel Display for Augmented Reality Smart glasses (MICROPIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The nascent global augmented reality market is expected to exceed $60 billion in 2023, and offers a lot of growth opportunitites. We expect Augmented Reality to become a part of everyday life as AR smart glasses will make people more connected than ever, in real time, with hands-free and heads-up toward the world. They will also be used to increase productivity for companies in most industries. The race to produce the first pair of commercially successful augmented reality glasses is on, but all products present major drawbacks such as low brightness, low resolution, big size, small field of view, reduced eye box resulting in limited experience. All major drawbacks are linked to microdisplays' weaknesses. Many miniaturised components from the smartphone industry can be integrated into smart glasses but the display is the bottleneck and the main challenge for manufacturers. Current commercialized microdisplays will never meet requirements to produce cutting-edge smart glasses. A new generation of microdisplay has to emerge. MicroLED technology, the same LED technology which revolutionized general lighting 10 years ago but scaled down to microscale pixels, is the most promising solution and must be developed. MicroLED displays have the potential to change everything as they can offer unparalleled higher brightness, a better reliability be more compact, offer lower latency, provide better contrast ratio and be energy efficient compared to current display technologies. This is exactly what the AR smart glasses market needs. Our latest breakthrough innovation will bring the solution by allowing the fabrication of full color RGB matrices for high-end microdisplays, completely adapted to cutting-edge augmented & mixed reality smart glasses. It is a great opportunity and a good timing to scale-up Novagan in the global microdisplay market.

Keywords: microled,augmented reality,micro display,smart glasses,display,pixel
Lifestyle intervention in the perioperative process through digital service (LIVE INCITE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Pre-Commercial Procurement
Countries involved: Spain,Sweden,Denmark
Call: PCP - eHealth innovation in empowering the patient (H2020-SC1-2016-CNECT, 2016)
Start date: 2016-11-01
End date: 2021-09-30
Duration (months): 59.0
Total project cost (EUR): 4253479.25
EU funding (EUR): 3828131.34
Participants: 5
Project status: CLOSED

Lifestyle factors of the patient (e.g. smoking, hazardous alcohol drinking and malnutrition) are proven to be independent risk factors negatively impacting health outcome in the perioperative process. Evidence suggests that the implementation of intensive lifestyle intervention programs can significantly reduce the post-surgery complication risk and rehabilitation time . However, implementation of and compliance to such programs are today poor. In addition, possibilities to optimize the patients’ mental and physical state throughout the perioperative process are insufficient. LIVE INCITE aims to move beyond the current state of general information being provided about risks and post-surgery activities, to translating statistics and data to individual-specific information, making the individual plan “real” for the patient. We believe it is possible to leverage f i existing and new data, best practice behavioral change concepts, intuitive and easy-to-use user experience, modern communication and collaboration channels to integrate not only patients and care providers but also the patient’s family and friends, and new technology for continuous monitoring of and feedback on patient activities related to her defined plan. But, no matter which concepts and solutions the market will suggest, sustainability and scalability (related to the likely changing needs and pre-requisites of the specific procurer as well as the dissemination in and uptake from a European-wide procurer community) has to be enforced through principles related to interoperability, open architecture, and use of international standards. Through its consortia including specialized care hospitals, academia, patient organizations as well as collaboration and innovation platforms the project has the critical mass of knowledge to reach a truly innovative solution together with the supply side.

Keywords: perioperative medicine,highly specialized care,behavioral medicine,lifestyle intervention
Promoting Archaeological Science in the eastern Mediterranean (Promised)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Cyprus,Belgium,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 991550.0
EU funding (EUR): 991550.0
Participants: 3
Project status: CLOSED

Promised meets the Twinning objectives by addressing challenges in networking and deficiencies in research performance at the Cyprus Institute. Firstly, it aims to significantly strengthening research in Archaeological Science, and secondly to bring the quality of the CyI Graduate School programmes to the level of similar programmes in the advanced partner institutions. The Archaeological Science research teams at the University of Cambridge and KU Leuven were chosen as recognised leaders in both areas, with complementary strengths in their disciplinary coverage, scientific expertise, and the nature of their doctoral programmes, being based in the Humanities and Natural Sciences, respectively. The aims will be achieved through a carefully developed programme of actions linking experienced researchers, administrative and technical staff at the advanced institutions with their counterparts at the CyI, through exchange visits, secondments, and joint activities. The doctoral programme at the CyI will be revised from the admission process through to the final examination, consciously taking account of the unique geopolitical position of Cyprus as the gateway between Europe and the Middle East, and the educational challenges this poses for applicants with non-Western educational backgrounds. The scientific training and mentoring of CyI staff and students will follow the Community of Practice philosophy, while also working towards a canonisation of best practice in Archaeological Science. The combination of formal research skills courses at the Graduate School with research-led training will include field-based summer schools and lab-based workshops addressing specific themes. The input received from the advanced partners throughout the duration of the project will be taken up by CyI researchers and staff, and is expected to result in ongoing financially sustainable best-practice dissemination events reaching out to the wider region of the EMME and the Balkans.

Keywords: archaeological science,doctoral training,networking,eastern mediterranean,middle east