Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Blood-brain barrier: from molecular mechanisms to intervention strategies (Ctrl-BBB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2286542.5
EU funding (EUR): 2286542.5
Participants: 1
Project status: SIGNED

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer synergistic approaches between the zebrafish and the mouse model, to bring BBB research in the era of highly parallel genetic approaches and BBB-focused therapeutic strategies for brain disorders.

Keywords: blood brain barrier,vascular biology,neurovascular biology,zebrafish
One-of-a-kind therapy for crossed eyes. Helping families to reduce emotional and financial burden of eye therapy. (PLUTO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-10-31
Duration (months): 36.0
Total project cost (EUR): 2767900.0
EU funding (EUR): 1937530.0
Participants: 1
Project status: SIGNED

Strabismus (crossed eyes) and ambylopathy (lazy eye) are among the most common eye problems in children, affecting up to 5% of the population. Untreated, they may lead to reduced vision in one/both eyes or even complete loss of sight. Despite the treatment methods offered currently by medicine (surgery, eye patch, stationary vision therapy), the need to of cheap and enjoyable treatment for home use that would significantly shorten therapy time and have sufficient effectiveness has not been fulfilled. At RemmedVR, in collaboration with doctors with outstanding achievements in pediatric ophthalmology from Poland and the EU we took the challenge to create a unique world’s first system designed for remote home use, reducing therapy time from six months to 90 days on average, with minimized doctor visits while eliminating psychosocial impact on the child. RemmedVR’s tracking sensors are also unique among available vision therapies. Advanced motion tracking system makes the perception of virtual reality (VR) environment more natural and comfortable to train visual perception with games designed to stimulate the cerebral cortex for neuropathic stimulation. Considering costs of treatment and shorter therapy duration, RemmedVR is available for at least half the price of standard vision therapy and 4 times cheaper than our competitors. It also allows doctors to attend more patients and increase income. The primary objective of the Phase 2 project is to adopt virtual reality-based technology to optometry needs. Our value proposition is based on objective measurement which can be done only through tailor-made eye tracking and hand tracking sensors. Having a batch of representative prototypes, we have started proving the effectiveness of our system in pre-clinical trials. We further want to test our system in full clinical trials. Other steps covered in this project are related to scaling business and implementation of commercialization plan.

Keywords: strabismus,ambylopathy,crossed eyes,lazy eye,child,eye problems,eye impairment,virtual reality,gaming,therapy
Genome-wide analysis of RNA and protein interacting profiles during a plant virus infection (InterAcTEV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Plant (+)strand RNA viruses account for important losses in crop yields worldwide. They complete complex infectious cycles by replicating, moving and inactivating plant defense mechanisms through multiple interactions of their RNA or proteins with host factors. Plants have evolved two main antiviral immunity systems operated by ARGONAUTE (AGO) proteins that target viral RNAs in the RNA silencing pathway or by resistance proteins that recognize viral-encoded proteins through protein-protein interactions. However, neither the identification of AGO target sites in viral RNAs nor the elucidation of the entire repertoire of proteins interacting with viral proteins has been reported for any plant virus. Now, the recent development of new technologies (and associated tools) such as high-throughput DNA sequencing and high performance mass spectrometry (MS) platforms makes possible to address these questions at a genome-wide level. InterAcTEV will combine these new technologies to study the recently described Arabidopsis/Tobacco etch virus (TEV)-TAMPS pathosystem with a multidisciplinary approach aimed to identify AGO target sites in TEV RNAs and to generate the first complete protein-protein interactome map for a plant virus. First, RNA-immunoprecipitation coupled with high-throughput sequencing methods will be optimized to identify AGO target sites in TEV RNAs at a genome-wide level. Second, we will combine novel high-affinity purification methods with MS analyses to identify the specific pool of Arabidopsis proteins interacting with each TEV protein. InterAcTEV will generate key knowledge to open new avenues for the understanding of resistance mechanisms in plants and to develop novel antiviral strategies for crop protection and securement of world’s food supply. Finally, the funding of InterAcTEV will allow the Experienced Researcher to initiate his own research project in the host laboratory and facilitate his transition to an independent research position in Europe.

Keywords: plant virus interaction,arabidopsis,tobacco etch virus,argonaute,small rna,rna silencing,high throughput sequencing,mass spectrometry,immunoprecipitation,rip seq
Forecasting RangE dYnamics of Alien species under climate change. (FREYA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Frameworks for assessing the risk of invasive species under climate change are still not widely applied although biological invasions and climate change rank among the top threats to biodiversity, economy and human well-being globally. This is at least partly due to a lack of reliable predictions of invasion success and range dynamics under changing climates. Mechanistic and process-based models are theoretically well-suited to generate spatially explicit forecasts of species invasion risk, as they are ecologically realistic and allow accounting for species evolutionary potential. Their use however lags behind that of less data-demanding and relatively easy to use correlative tools. This project will therefore investigate the ecological and evolutionary factors determining when more complex but ecologically realistic mechanistic and process-based model approaches yield better forecasts of invasion risk than simple correlative tools. The project will combine a detailed investigation of well-known avian invader (the ring-necked parakeet) with a multi-species assessment of a large number of avian invaders in Europe and Australia. These invasions offer an exceptional model system for answering the questions at hand. This timely Fellowship answers to calls to move from patterns to processes, and as recent European legislation requires consideration of synergistic impacts of climate change on biological invasion risks, Fellowship outputs will relevant for policy as well. The host institute (CMEC) is at the forefront of macroecology and climate change biology, and brings worldwide access to excellent researchers with experience directly relevant for the Fellowship (C. Rahbek, M. Araújo, D. Nogués-Bravo). I will not only benefit from deepening my analytical skills and conceptual understanding of macroecological research frameworks, but CMEC’s training experience in academic leadership will enable me to reach a position of professional maturity at a high international level.

Keywords: invasive alien species,climate change,niche conservatism,ecological forecasting
TRansport in the InterioR of the Earth from Modelling and Experiments (TRIREME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999928.75
EU funding (EUR): 1999928.75
Participants: 1
Project status: SIGNED

Project TRIREME will explore the transport of energy through minerals and melts at the high pressure and temperature conditions of the Earth’s interior, and the consequences for Earth’s evolution and its present dynamics, from the core to the biosphere. Deep transport determines the age and growth behaviour of the inner core, the thermal history of the mantle, and the longevity of Earth’s life- and civilization-sustaining magnetic field. This project will determine the transport behaviour in deep Earth materials via cutting edge experiments at extreme conditions, constraining heat transport, electrical conduction, and fluid flow in Earth’s core and lower mantle. Accurate numerical modelling of the complex experiments will robustly establish underlying transport properties and their uncertainties. Applying these methods in geophysically-relevant minerals and melts, including iron alloys and mantle minerals, at the true conditions of Earth’s interior, our results will constrain the dynamics of deep Earth systems, to better understand and predict their evolution and effect on the surface environment. We will examine in particular the current and historic conditions of Earth’s core and dynamo-driven magnetic field in the context of geodynamic and geomagnetic constraints on deep dynamics. Project TRIREME (Latin: "three rows of oars") will thus comprise three lines of investigation: 1) the laboratory study of transport in Earth's interior using novel and cutting-edge experimental techniques at high pressure and temperature; 2) the numerical modelling of experiments in unprecedented detail to accurately characterise observed transport phenomena at extremes; and 3) consideration of the geodynamic phenomena emerging from the underlying transport behaviour. In breaking through longstanding challenges in the measurement of transport at extreme conditions, this work will set course to make a historic impact in the study of Earth systems’ dynamics.

Keywords: high,pressure,temperature,laser,heated,diamond,anvil,cell,thermal,conductivity,viscosity,experiment
Preparing for RSV Immunisation and Surveillance in Europe (PROMISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Spain,Spain,Italy,Spain,Belgium,Belgium,Belgium,Sweden,Finland,Finland,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Restricted Call to maximise impact of IMI2 JU objectives and scientific priorities (H2020-JTI-IMI2-2020-22-single-stage, 2020)
Start date: 2021-11-01
End date: 2024-04-30
Duration (months): 30.0
Total project cost (EUR): 7024387.0
EU funding (EUR): 3744375.0
Participants: 22
Project status: SIGNED

RSV causes severe disease in the very young and elderly and results in substantial healthcare costs. In the last 4 years, substantial progress has been made in development of products for active and passive immunization against RSV, with 19 products currently in clinical development. In 2017, we were funded by IMI to set up RESCEU project (Grant Agreement number 116019), which is the single largest consortium currently working on RSV and has addressed several of the key evidence gaps to inform the introduction of an RSV vaccine. However, new gaps in evidence have emerged and many key requirements for the introduction of a novel RSV vaccine into national immunisation programmes (not addressed within RESCEU) remain unmet. PROMISE’s vision is to seamlessly build on, exploit, and add value to the significant achievements of RESCEU to prepare for the imminent introduction of an RSV vaccine. Expanding the existing RESCEU network to include 5 new partners, PROMISE comprises of 5 distinct but inter-connected work packages (WPs). WP 1 will conduct epidemiological and cost-effectiveness analyses marshalling data from systematic reviews; national and regional disease registries; surveillance programmes and linked routine healthcare datasets. WP2 will foster a consensus and develop an operational plan for expanded coordinated RSV surveillance and reporting activities; post-licensure monitoring and evaluation of products for RSV immunization across Europe. WP3 will initiate new prospective studies to address key gaps in existing knowledge (RSV disease severity scores, asthma in school age children) and assemble biobanks for biomarker validation. WP4 will validate temporally and at mucosal level biomarkers that were identified in RESCEU adopting state of the art technologies. WPs 1-4 will develop high-quality, sustainable, robust data collection systems that link closely with public health/regulatory bodies/health care providers for informing policy and regulatory processes.

Keywords: rsv disease,rsv epidemiology,rsv surveillance,rsv sequelae,retrospective,routine data,prospective data,literature reviews,burden of disease,cohort,studies,biomarkers,biobank,immunisation
Cloud-based Monitoring Service for Software Defined Networks (SDN-Polygraph)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-05-01
End date: 2018-10-31
Duration (months): 30.0
Total project cost (EUR): 1496042.5
EU funding (EUR): 1047229.75
Participants: 1
Project status: CLOSED

Most enterprises depend on the Internet and on computer networks. Costs associated to network malfunctions are huge and have been estimated via market surveys from around 30,000€/hour on average, which yields average yearly losses of more than 5M€ per company. Because network downtime is so costly, companies invest in network visibility solutions. The market of Network Performance Monitoring (NPM) is currently estimated at 2,200M€, growing at >11% yearly. However, enterprises are still not investing as much as they should in network visibility, for two main reasons: Deployment complexity and Upfront costs. Current products are hardware based, are very expensive and their license costs must be paid up-front. Should these two barriers fall, the NPM market would explode, as every mid-to-large company, even the larger SMEs, would acquire such solutions. The first requirement to avoid malfunctions and correctly operate a network is visibility (the ability to understand what happens in a network). A technical revolution is currently undergoing, called Software-Defined Networking (SDN). SDN allows software components to act on the network and make it “programmable”. SDN opens the door to create a zero-hardware network visibility product that can be deployed with one click, seamlessly collect network traffic statistics, and send them to the cloud for analysis and can also alter the behaviour of the network based on that analysis. Through SME Instrument Phase 1, Talaia has developed a Minimum Viable Product demonstrating its technological viability, has implemented a Business Plan which proves the feasibility of the solution and has placed itself in an advantageous position to gain this new market niche. Talaia will develop a fully-featured product, and offer it as a service using the Software-as-a-Service (SaaS) model and take it to international markets for large-scale commercialization. Forecasts estimate 64 new jobs and sales of more than 17M€by 2022.

Keywords: software defined networks,network visibility,network management,software as a service
Male Family Caregiver’s Well-being: Balancing Work and Long-Term Care in France and Japan (CAREANDWORK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Rapid demographic ageing in Europe, as highlighted in Horizon 2020 health priorities, makes the challenge of long-term care increasingly pressing. Despite substantial discussions on caregivers in policy making and academic research, a rapidly emerging new group of relatively young male family primary caregivers who often also work are largely understudied and increasingly risk giving up their employment. Inadequate understanding of gendered caregivers jeopardises not only carers but also care receivers, other family members and society as a whole: better outcomes for the elderly are substantially dependent on the well-being of caregivers. For Europe it is relevant and timely to learn from ‘super-aged’ Japan about such gendered carers’ practices, particularly their use of innovative ‘technologised care’ emphasised by Japan’s large-scale welfare programme. Yet, learnings need to be contextualised to reflect European societies, such as France’s highly developed family policies. Hence, this project aims to address the gap in understanding of gendered male family care practices to inform policy development, focusing on the relevance and application in France of practices from Japan. This project will develop an innovative multidisciplinary approach to comparative understanding and policy development: building on the researcher’s anthropological PhD on men and masculinities in family the project develops ‘short-duration fieldwork’ in Paris and Tokyo, which is complemented by capabilities developed through training by hosts Science Po and Oxford in sociology and policy analysis. The project findings will be disseminated to potential users, such as policy makers, academic and non-academic researchers, also by organising an international workshop and to the public through popular media. The research project develops the researcher’s specific capabilities and transferable professional skills that substantially open up new career paths, notably in policy research in Europe.

Keywords: gender,sociology,ageing,masculinity,social anthropology,well being