Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Voltage-sensing nanorods for super-resolution voltage imaging in neurons (NanoVoltSens)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

In the last decade, the rapidly developing optical imaging field has significantly improved our understanding of information processing in the brain. Although a number of promising tools have been designed, sensors of membrane potential are lagging behind. In this project we aim to characterize an innovative voltage sensor for neurons that is fundamentally different from the existing ones. Our sensor is based on targetable voltage-sensing semi-conductor nanorods (vsNRs) that self-insert into the neuronal membrane. The rods optically and non-invasively record action potentials at the single particle level, at multiple sites, and across a large field-of-view. Such vsNRs offer unique advantages, including: (1) large voltage sensitivity, (2) ratiometric imaging based on a large spectral shift as function of voltage, (3) very fast response times in the range of ns, (4) very high brightness that affords single-particle detection, and (5) excellent performance in the near-infrared spectral range. The goal of this project is to validate, calibrate, and use vsNRs in neurons, focusing on dendritic spines and dendritic voltage spikes. After initial characterization of vsNRs in neurons, we will take advantage of the exceptional spatial and temporal resolution provided by vsNRs in order to access electrical properties of individual dendritic spines, as well as to make use of the red-shifted emission of vsNRs in order to record simultaneously membrane potential and calcium fluctuations at dendritic branch points. The project is to be accomplished in the laboratory of Dr. Antoine Triller at the IBENS, Paris by Dr. Anastasia Ludwig, who has extensive experience in molecular neurobiology, including analysis of dendritic spine morphology and dynamics. Based on our preliminary data, we are certain to be able to provide within two years a viable and user-friendly voltage-imaging technology that will be widely applicable for the study of signal integration in the brain.

Keywords: voltage sensors,dendritic spines,dendritic excitability,semi conductor nanoparticles,quantum dots
Elucidating the causes and consequences of the global pattern of epigenetic variation in Arabidopsis thaliana (EPICLINES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 2498468.0
EU funding (EUR): 2498468.0
Participants: 1
Project status: SIGNED

Epigenetics continues to fascinate, especially the notion that it blurs the line between “nature and nurture” and could make Lamarckian adaptation via the inheritance of acquired characteristics possible. That this is in principle possible is clear: in the model plant Arabidopsis thaliana (Thale cress), experimentally induced DNA methylation variation can be inherited and affect important traits. The question is whether this is important in nature. Recent studies of A. thaliana have revealed a pattern of correlation between levels of methylation and climate variables that strongly suggests that methylation is important in adaptation. However, somewhat paradoxically, the experiments also showed that much of the variation for this epigenetic trait appears to have a genetic rather than an epigenetic basis. This suggest that epigenetics may indeed be important for adaptation, but as part of a genetic mechanism that is currently not understood. The goal of this project is to determine whether the global pattern of methylation has a genetic or an epigenetic basis, and to use this information to elucidate the ultimate basis for the global pattern of variation: natural selection.
iTRUST: In-time TReatment of acUte ischaemic STroke (iTRUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The problem: Intravenous thrombolysis is by far the most effective treatment of Acute Ischaemic Stroke (AIS), and its use can independently strongly increase the proportion of AIS patients surviving. However, in the emergency setting of AIS an excess of information must be considered by the physician including imaging, clinical presentation and electronic health record data before safely inferring on the suitability of thrombolytic therapy. Still, the therapeutic decision is largely dependent on the capacity of the expert radiologist in predicting what is the outcome for the given patient after applying the pharmacological treatment – a problem further compounded by the heterogeneity in AIS progression. The solution: iTRUST solution is a clinical decision support system that uses Convolutional Neural Networks to predict the outcome of the AIS for each patient based on the patient’s biomarkers as well as clinical information. The prediction is presented as a probability of infarction when using pharmacological treatment or mechanical recanalization, making the prediction much more useful compared to current methods. The market: The global AIS diagnosis and treatment market was valued at USD 1.2 billion in 2013 and is estimated to reach a market worth of USD 1.9 billion in 2020 growing at a CAGR of 6.3% from 2014 to 2020. Given the high incidence of AIS cases and the high importance of quickly allocating the appropriate therapeutic intervention, we have reasons to believe that iTRUST solution can generate an accumulated turnover exceeding EUR 32 million, five years post-project.

Keywords: acute ischaemic stroke,clinical decision support system,convolutional neural networks
Cyber preparedness actions for a holistic approach and awareness raising in the MARitime logistics supply chain (Cyber-MAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Spain,Sweden,Greece,Finland,Greece,France,France,United Kingdom,United Kingdom
Call: Cybersecurity preparedness - cyber range, simulation and economics (H2020-SU-DS-2018, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 7154505.0
EU funding (EUR): 6018367.5
Participants: 15
Project status: SIGNED

Cyber-MAR is an effort to fully unlock the value of the use of cyber range in the maritime logistics value chain via the development of an innovative simulation environment adapting in the peculiarities of the maritime sector but being at the same time easily applicable in other transport subsectors. A combination of innovative technologies are the technology enablers of the proposed Cyber-MAR platform which is not only a knowledge-based platform but more importantly a decision support tool to cybersecurity measures, by deploying novel risk analysis and econometric models. CSIRTs/CERTs data collected will be analysed and feed the knowledge-based platform with new-targeted scenarios and exercises. Through Cyber-MAR, the maritime logistics value chain actors will increase their cyber-awareness level; they will validate their business continuity management minimizing business disruption potential. Cyber-MAR will act as a cost-efficient training solution covering the maritime logistics value chain.

Keywords: cyber ranges,maritime cybersecurity,maritime logistics value chain
The European network of Women web Entrepreneurs Hubs (WeHubs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Germany,Norway,Greece,Belgium,France,France,France,United Kingdom,Lebanon
Call: Web Entrepreneurship (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 756721.25
EU funding (EUR): 756721.0
Participants: 9
Project status: CLOSED

It is generally acknowledged that the web entrepreneurship sector can contribute significantly to the competiveness and economic growth of countries and regions. However, Europe is clearly lagging behind given that even though there are lots of European web start-ups, most of them rarely grow up to become global leaders. In this context, the position of women seems particularly weak given that only a very small percentage of them are web entrepreneurs. Taking into account the limited development of web entrepreneurship in Europe as well as the limited participation of women in the web economy the WeHubs project seeks to create a favourable environment for women web entrepreneurs, by linking together local fragmented ecosystems nodes, and foster networking and exploitation of synergies, into the first European Network for Women Web Entrepreneurs Hubs. In this respect the project is aimed at providing a strong support to women web entrepreneurs and existing web entrepreneur’s ecosystems enabling the latter to provide dedicated services to women. As a result the project will foster the creation and scaling of web start-ups created by women (impact on women), strengthen the existing web entrepreneurs ecosystems through networking and complementary services (impact on ecosystems) and support the emergence of a dynamic European ecosystem for women web entrepreneurs contributing to the formulation of relevant policies, support the implementation of start-up Europe initiative and the wider enforcement of the European digital sector (policy impact).

Keywords: web entrepreneurship,women web entrepreneurs,ecosystem nodes,motivation and encouragement,startup europe
Mass production platform for L-EVs (KTX-20)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2018-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tuk Tuks are already a well-known charming means of 3-wheeler transportation in many countries, especially in Asia, with many different applications. At the moment, the Tuk Tuk Holding company (TTH) is the only OEM in the world that produces eTuks with 6 passenger seats. The market is growing fast: in 2015 more than 210 eTuks were sold in almost 30 countries, and the eTuks are so successfully exploited in various niches and in various ways. The company’s total volume has grown over 240% over the last 2 years and the 2016 turnover is projected at over 4MEUR, with an EBITDA of over 750kEUR. Recently, TTH has crafted a highly innovative version of the successful 6 year old technology platform. This novel platform “KTX-20” is lighter, more efficient, modular, has a lower TCO, and can host either 4 or 3 wheels. It allows modular sizing and scaling of batteries, and fits the upcoming European and Asian legislation for road vehicle approval. Hence, this platform allows ultimate modular scalability to support a mere endless variation of “L-category” vehicle models and has great potential for upscaling KTX-20 electric cars on a global level. However, this unlimited freedom represents an inherent risk to invest the limited TTH development budgets in the wrong business opportunities. Hence, this calls for an in-depth market research to explore the most promising business applications and related risks in this SME-INSTrument Phase 1 proposal. Specific objectives in this H2020-SMEINT Phase 1 feasibility study are: • Explore at least 5 (up to 10) promising business cases for the KTX-20 platform. • Evaluate the required specifications and characteristics of these applications with potential partners and/or clients. • Elaborate on a detailed business plan (D1).

Keywords: electric transport,l ev
Systems Chemistry: Steps Towards De-Novo Life (ToDL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 2499974.51
EU funding (EUR): 2499974.51
Participants: 1
Project status: SIGNED

Can we synthesise life de-novo in the lab? This is one of the Grand Challenges of contemporary Science. Overall objective of this project is to set important steps in turning chemistry into biology by building fully synthetic chemical systems that contain and integrate some of the essential elements of life: replication, metabolism and compartmentalisation. Functional coupling of any of life’s essential elements has not been achieved, at least not without making use of biomolecules. We now aim to achieve such coupling and develop fully chemical systems to become increasingly life-like. Specific aims are: 1. Achieve and explore Darwinian evolution of a fully synthetic system of peptide-based self-replicating molecules. 2. Develop self-replicating molecules that are capable of catalysing not only their own formation, but also other chemical reactions. We will specifically target chemical reactions that result in the production of building blocks which the replicators can utilize to replicate, thereby integrating replication with a rudimentary form of metabolism. 3. Achieve self-reproducing compartments and develop ways to couple replication inside compartments with compartment division. Three parallel approaches will be explored, based on (i) vesicle-type compartments made from self-replicating molecules; (ii) coascervates and (iii) compartments made by surfactants that are produced by catalytically active self-replicators. 4. Extend replication from peptide-based building blocks to ones containing nucleobases. We also plan to investigate reaction networks made from mixtures of peptide- and nucleobase-containing building blocks). 5. Develop kinetic modelling tools that allow an efficient exploration of multi-parameter space of the reaction networks developed in 1-4. Through stochastic computational modelling we will address mechanistic issues that are experimentally intractable. Furthermore, modelling will allow a more efficient exploration of multi-parameter space.

Keywords: dynamic combinatorial chemistry,systems chemistry,synthetic life
Fucosylated Clusterin: a novel mechanism of tumor escape from immune response (FUCTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-15
End date: 2020-06-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Clusterin (CLU) is a ubiquitous glycoprotein that function as an extracellular chaperone, binding to apoptotic cells and stressed-proteins and preventing the generation of insoluble aggregates. Although CLU is overexpressed in many type of cancers and associated with bad prognosis, the nature of this association remains obscure. It has been previously discovered an isoform of CLU present in seminal plasma that bears fucosylated glycans that confers the ability to bind to DC-SIGN; an endocytic C-type lectin receptor expressed on dendritic cells (DCs) and macrophages (MAC) that has been associated with immunosuppression. Our preliminary results showed spontaneous regression of tumors in CLU-/- mice after adoptive transfer in 2 models. We also observed that CLU present in breast cancer bears fucosylated glycans with the ability to bind to DC-SIGN. We hypothesize that tumor fucosylated CLU (Fuc-CLU) promotes immunosuppression by targeting tumor cell-associated antigens to DC-SIGN expressing DCs and MAC, promoting antigen presentation in a tolerogenic context. In this sense, Fuc-CLU could represent a new mechanism of tumor escape from immune response. The main objectives are: to analyse Fuc-CLU expression pattern and production by tumor and stromal cells; to address the role of Fuc-CLU in immune modulation and tumor cell-associated antigen presentation; and to study the effect of Fuc-CLU on tumor development in an in-vivo model. The expertise of Dr. Amigorena and Institute Curie represent a major competitive advantage for the project. The results are expected to be published in peer-reviewed journals of high impact (with Open Access whenever possible), communicated in scientific meetings and to society at large. Expected results and deliverables will enhance the knowledge base and excellence of the European Scientific Community in the field anti-tumor immunity. This experience will be a key step for my scientific development to reach an independent position.

Keywords: anti tumor immunity,immunosupression,antigen presentation,glycosylation
Human IMMune profiling of Graphene NanoRibbons (IMM-GNRs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2019-11-30
Duration (months): 18.0
Total project cost (EUR): 128595.6
EU funding (EUR): 128595.6
Participants: 1
Project status: CLOSED

To promote the Safe and Healthy use of ‘Future and Emerging Technologies’ such as innovative carbon-based nanomaterials, the study of their interactions with blood immune cells is of fundamental importance for any translational medicine application, in particular, those requiring intravenous injection. Taking Graphene Nanoribbons (GNRs) as model, IMM-GNRs will overcome the limits of conventional nano-immunotoxicology to achieve a comprehensive picture of their immune activity in relation to their structural properties (shape, edge structures, width, size…), enhancing the EU excellence in 2D materials research. IMM-GNRs Specific Objectives are: 1° To design and synthetize a wide variety of highly stable and water-soluble GNRs 2° To perform quantitative GNRs deep immune phenotyping on 17 diverse immune subpopulations, demonstrating the potential of a forefront approach coupling an array of high-throughput technologies 3° To correlate immune phenotype and physicochemical properties, investigating the potential molecular mechanisms underlying the observed immune-functions, in order to provide an outstanding paradigm shift in the nanomaterials engineering and classification proposing the novel “immunity-by-design” concept. IMM-GNRs multidisciplinary action will provide the fellow with new career perspectives and contribute to European excellence and competitiveness by: I. Developing expertise in cutting-edge technologies whose diffusion is still limited in Europe; the lack of EU experts make the Fellow’s experience (she will be the first worldwide to apply CyTOF technology to the nanoworld) an high added value to European Academia and Industrial sector; II. Setting long-term collaborations among leading groups of nanotechnology and cell biology; III. Gaining exposure to the industrial sector: GNRs as immunomodulators can give rich possibilities for new therapeutic approaches in particular in the field of immunotherapy.

Keywords: graphene,2d materials,graphene nanoribbons,carbon nanomaterials,nanotoxicology
The true cost of migration: testing the species-energy hypothesis by quantifying the energy budget of free flying avian migrants under spatially explicit environmental conditions (TesSEH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Migration is a key life-history stage for many avian species and underpins the distribution of biodiversity on Earth. The species-energy hypothesis states that energetics underlies spatial- and temporally-specific patterns; yet the energetic balance for free-flying migratory species is poorly understood due to the inherent difficulties in studying individuals across vast geographic scales. To date, it has not been possible to obtain a field-derived metric of energetics in passerines let alone relate it to the environmental energetic conditions experienced. Major advances at the MPI-AB in the miniaturisation of heart-rate loggers, and the launch of ICARUS tracking technology with high spatio-temporal resolution, will now enable unique insights into energetically costly flight behaviour over the full annual cycle. By filling a technological and a conceptual gap, the ER will be the first to develop a novel, integrated approach to quantify the true energetic costs in the natural environment across a continuum of flight strategies, and calibrate metabolic costs under controlled settings to transform the research field of energetics. Empirically-derived data, resulting from this action, will be used to test if the species-energy relationship is applicable to the vast majority of small songbirds which change their distribution in response to seasonal variation in conditions and resources. Furthermore, this will enable the development of a tool to refine flight performance models and determine the response of this biological system to climate change. It will permit explicit testing of the species-energy relationship under seasonally specific environmental conditions, with a unique approach of incorporating energetic demands into the system. Cumulatively, fulfilling the objectives of TesSSEH, will significantly contribute to biogeographic theory, develop our understanding of energetically efficient physiological traits and revolutionise avian energetic models.

Keywords: avian migration,telemetry,flight performance,energetics