Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Signal Transduction and Epigenetic Mechanisms of Breast Cell Plasticity and Cancer (STEM-BCPC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2499250.0
EU funding (EUR): 2499250.0
Participants: 3
Project status: CLOSED

Breast cancer is diagnosed in ~1.4 million women worldwide and ~500,000 lives are lost to the disease annually. Patients may do well after surgery and initial treatment, but drug resistant and fatal metastases often develop. Improved treatment options are urgently needed. The connecting thread of this project is the identification of epigenetic drivers of breast cell fate, tumor heterogeneity and metastasis. Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis and is one of the most important and clinically relevant areas of cancer research. Tumor heterogeneity results from genetic and epigenetic alterations that enhance the plasticity and fitness of cancer cells in the face of hurdles like the metastatic cascade and anti-cancer therapies. Unfortunately, the driving molecular mechanisms remain unclear, particularly the potential interplay between signalling pathways and epigenetic programs. This interdisciplinary project uses pathophysiologically relevant models and state-of-the-art technologies to identify molecular mechanisms underlying crosstalk between key signalling pathways and epigenetic programs in the normal and neoplastic breast. We hypothesize that interfering with these programs will decrease tumor heterogeneity. We will address the effects of: - SHP2/ERK signalling on the epigenetic programs of tumor-initiating cells (Aim 1) - PI3K pathway hyperactivation on the epigenetic programs underpinning cell plasticity (Aim 2) - Epigenetic regulators on normal mammary cell self-renewal and on metastasis (Aim 3) By investigating the integrated effects of key signalling pathways and epigenetic programs in normal and neoplastic breast, this multipronged project will identify and validate mechanisms of cell plasticity. The derived mechanistic understanding will generate means to interfere with tumor heterogeneity and thus improve the efficacy of anti-cancer therapies and ultimately the clinical outcome for patients with breast cancer.

Keywords: phosphatases pi3k signaling epigenetics stem cells
A groundbreaking renewable-energy technology for reducing truck emissions (X-TEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TuWing UG is a German SME, based in Berlin, and is specialised in the development of technologies for reducing passenger and commercial vehicle energy consumption. Today, trucks are representing a significant contributor for the overall transport emissions (CO2, NOx and particulates) within the EU which shall be mitigated according EU white paper for a more efficient and cleaner EU transport system until 2050 Globally, transportation is accountable for 21,7% (approx. 7 billion metric tonnes) of fossil fuel CO2 emissions, 50% of NOx emissions and significant amounts of other pollutants. Further, fossil fuels used in transportation cost its users around 100 trillion dollars per year. Due to more stringent emission regulations in the EU from 2017 onwards, the competiveness of the end-user e.g. forwarding companies will be stronger influenced by the truck efficiency in the future. Today’s truck fuel costs are presenting 25%-33% of the operating costs which can be either reduced by e.g. a more efficient truck engine and / or by an upgrade (aerodynamic etc.). Actually, SoA technologies like “Active Aero” or “Platooning” lead to fuel saving benefits of only between 3% - 10% but depend on boundary conditions e.g. at least three trucks are required for platooning. Therefore, Tuwing has developed X-TEC, a low-cost fabricated truck upgrade with significant fuel saving benefit that will become highly attractive for end-users. X-TEC is reliable, pragmatic and without logistic disadvantages able to support the EU white paper objectives by being an unconventional groundbreaking technology for significant fuel saving at trucks by at least 30% and will lead to a significant reduction of emissions (e.g. CO2).

Keywords: unconventional transport system,tractor trailer,truck upgrade,wind turbine,fuel savings,greenhous,gas reduction,renewable energy
INNOVATIVE AND EFFICIENT SOLUTION FOR PRODUCTION IN MICROALGAE OF EASILY EXTRACTIBLE AND HIGHLY PURE ASTAXANTHIN FOR ADDED-VALUE PRODUCTS (ASTEASY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-03-01
End date: 2021-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Astaxanthin is a carotenoid with a high commercial value. Its high anti-oxidant activity makes Astaxanthin being used as a food/feed supplements, in cosmetics, and in nutraceutics. Microalgae are the main primary sources of Astaxanthin, being produced at industrial level mainly by cultivation of the green alga Haematococcus pluvialis with high costs for cultivation and extraction, hindering its market. In the ERC-StG-SOLENALGAE project the investigation of the role of carotenoids in photoprotection in microalgae led to the development of an innovative platform for Astaxanthin production. Strains with high Astaxanthin accumulation were indeed obtained by metabolic engineering in the green alga Chlamydomonas reinhardtii (usually not accumulating Astaxanthin), producing up to 4 mg/L per day in non-optimized growth conditions. Astaxanthin production by bkt15 strain revealed unique advantages compared to other source of natural Astaxanthin: production of Astaxanthin in continuous, in a single cultivation step; high bio-accessibility for animal or human assimilation; easier extraction of astaxanthin even without costly cell pre-treatments; lower extraction costs and no contamination from oxidant molecules as chlorophylls during extraction process. These advantages lead to a potential increase in pure Astaxanthin productivity up to 16-fold higher than the current methods. ASTEASY PoC aims to the technological development of the new system, by optimizing the cultivation conditions and extraction processes of Astaxanthin from the bkt15 strain and validating the performances in 60 litres demonstrator units. We will also identify and protect the IP generated and analyse the certification needed for commercialization. A business plan will be drafted as a result of interactions with stakeholders and literature analysis, to define market size and trends, and consolidate the business model (Astaxanthin production through a dedicated spin-off vs licensing to Astaxanthin producers).

Keywords: carotenoids,astaxanthin,microalgae,cosmetic,plant biotechnology,photosynthesis,pigments,antioxidants
Patented modified-immobilized enzymes used in the production of biodiesel at commercial scales using any type of feedstock. (Usewaste)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Biodiesel is an environment-friendly fuel with clear and substantial advantages over conventional diesel, but even at full production it could only ever meet around 8% of the diesel market. Currently, 95% of the world biodiesel is produced from high-grade feedstock such as rapeseed, sunflower oil, and soybean oil (high-grade feedstock). This led to major environmental problems such as serious destruction of vital soil resources, deforestation and large usage of the available arable land. The negative effects of high-grade feedstock use in biodiesel production resulted in their exclusion from REDII - the proposed new EU mandate that caps high-grade feedstock biodiesel blending at 3.8% by 2030. In order to meet REDII’s minimum 6.8% blend from alternative feedstocks, the industry needs to produces biofuel such as biodiesel from secondgrade feedstocks, which has technical issues using current production methods. TransBiodiesel Ltd. has patented TransZyme A, an immobilized enzyme technology for the production of biodiesel using any grade feedstocks (FFAs 0– 100%). Its main features are its tolerance to high concentrations of methanol and water and its long-term operational lifetime, which makes its use economically viable for biodiesel production. This innovative enzyme uses a unique continuous production method, which is more cost effective than current chemical production methods. The Usewaste project aims to leverage this innovation by creating a pre-industrial mobile, continuous enzymatic biodiesel production process on the sites of low-grade feedstock by-product producers. Usewaste mobile lab will be used by the Company to showcase their innovation and eventually foster first commercial partnerships. The company aims to put the biodiesel industry back on track.

Keywords: low grade feedstock,enzyme,circular economy,reuse
Stereoretentive-Enantioconvergent Catalysis: A New Concept in Asymmetric Synthesis (SEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2023-04-30
Duration (months): 66.0
Total project cost (EUR): 1498915.0
EU funding (EUR): 1498915.0
Participants: 1
Project status: SIGNED

This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive-enantioconvergent catalysis. This will represent a completely new method for accessing enantiopure materials starting from racemic substrates and will therefore impact all areas of synthetic chemistry. The ability to synthesise chiral molecules in enantiopure form is vitally important, most recognisably for the pharmaceutical industry. This is because the molecules of life are chiral (e.g., D-sugars and L-amino acids) and enantiomers often interact very differently with living organisms. Classically, asymmetric synthesis utilising racemic substrates is limited to achieving a maximum yield of 50% (e.g., kinetic resolutions). Enantioconvergent catalysis avoids this limitation with both enantiomers of the starting material being converted into a single enantioenriched product, thanks to complex stereoablative or stereomutative de-racemisation processes. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no de-racemisation required. This new concept will prove highly valuable for the synthesis of small enantiopure building blocks, which will be of high value in many areas of synthesis, and also for more complex late-stage transformations in complex molecule synthesis. Several approaches will be pursued to demonstrate proof-of-principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.

Keywords: enantioconvergent catalysis,asymmetric synthesis,domino reactions
Innovation Support Network East Mediterranean (InnosuppEastMed)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye,Türkiye,Türkiye
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 104292.5
EU funding (EUR): 104292.5
Participants: 5
Project status: CLOSED

Aim of the project is to become a true one-stop-shop for business and innovation support along the entire value chain,providing its services in the proposed region the context of COSME and HORIZON 2020 Programme and in line withthe Europe2020 strategy. innovation support services will helpstrengthen the competitiveness and sustainability of regional enterprises. Proposed project will include two acitivity type which are “Key account management under the SME Instrument ofHorizon 2020” and “Services to enhance the innovation management capacities of SMEs”

Keywords: innovation management,innovation support,sme instrument
Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society (CARBOCENTRE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Netherlands,United Kingdom
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-06-01
End date: 2027-05-31
Duration (months): 72.0
Total project cost (EUR): 9057250.0
EU funding (EUR): 9057250.0
Participants: 3
Project status: SIGNED

Enzymes that produce and degrade oligosaccharides and glycoconjugates are present in all kingdoms of life. The ability to visualize, modulate and understand these carbohydrate-active enzymes (CAZymes) therefore offers great potential for human health and sustainable industries. To provide a “disruptive” shift in our understanding, we adopt in this proposal a multidisciplinary approach combining structural biology, enzymology, computational chemistry, organic synthesis, and chemical biology, with major leaders in these fields part of our CARBOCENTRE Synergy Team. Three fundamental strands will specifically target and ‘capture’ glycoprocessing enzyme active sites. Biochemical and 3-D structural analyses will inform computational dissection of the reaction coordinate of key enzymes for human health and biotechnology processes. Building on our founding work on retaining glycosidases we will also target inverting glycosidases and glycosyltransferases. Following fundamental analyses, our probes will feed research in two major application domains of human health and biotechnology: 1. To provide visualization, diagnosis, and inhibitor assays and clinical lead compounds for enzymes in cancers and genetic diseases (lysosomal storage disorders). 2. To explore the natural diversity of CAZymes and to discover, quantify and optimize new enzymes for food and household applications and for biomass conversion to biofuels. In an iterative cycle, structural biology and enzymology (Davies, York), will inform, through structures of enzymes and enzyme-inhibitor complexes, theoretical and computational chemistry (Rovira, Barcelona), which in turn will guide the design and synthesis (Overkleeft, Leiden), of inhibitors and activity-based probes for ensuing chemical biology studies in the domains of biomedicine and biotechnology.

Keywords: carbohydrate active enzymes,activity based protein profiling,carbohydrate chemistry,enzymology,biofuels,computational design,glycobiology,glycochemistry
Developing a concept for a European minerals deposit framework (MINATURA 2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Austria,Spain,Austria,Belgium,Croatia,Slovenia,Serbia,Romania,Sweden,Bosnia and Herzegovina,Hungary,Poland,Slovakia,Slovenia,France,Netherlands,United Kingdom,Portugal,United Kingdom,Montenegro
Call: Mineral deposits of public importance (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 2092687.5
EU funding (EUR): 2092687.5
Participants: 29
Project status: CLOSED

The exploitation of minerals in Europe is an indispensable activity to ensure that the present and future needs of the European society can be met. This means that sufficient access is required to explore and exploit minerals. At the same time the mineral needs of our society must be met without compromising the ability of future generations to meet their own needs. Accordingly exploitable mineral deposits (known deposits, abandoned mines and historical mining sites) need to be assessed against other land uses, taking into account criteria such as habitats, other environmental concerns, priorities for settlements, etc. Access to mineral deposits, on the other hand, also meets public interests such as raw materials security (compared with many international access options). The deliberation between these diverse land uses requires adequate consideration of the exclusiveness, reversibility, and consequences on the surrounding. The overall objective of MINATURA 2020 is to develop a concept and methodology (i.e. a harmonised European regulatory/guidance/policy framework) for the definition and subsequent protection of “mineral deposits of public importance” in order to ensure their “best use” in the future. Providing a policy planning framework that comprises the “sustainability principle” for mining is the key driving force behind MINATURA.

Keywords: mineral deposit,minerals supply,land use planning,environment,directive
Advancing Anticipatory Behaviors in Dyadic Human-Robot Collaboration (An.Dy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Italy,Germany,Germany,Italy,Slovenia,France,Netherlands,Denmark
Call: Advanced robot capabilities research and take-up (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-08-31
Duration (months): 56.0
Total project cost (EUR): 3950025.0
EU funding (EUR): 3950025.0
Participants: 9
Project status: CLOSED

Recent technological progress in robot physical interaction permitted robots to actively and safely share with human a common workspace. Thanks to these technologies, Europe nowadays leads the robotic market in the niche of safety certified robots by endowing them with the ability to react to unintentional contacts. ANDY leverages these technologies and strengthen the European leadership by endowing robots with the ability to control physical collaboration through intentional interaction. These advances necessitate progresses along three main directions: measuring, modeling and helping humans engaged in intentional collaborative physical tasks. First, ANDY will innovate the way of measuring human whole-body motions developing the ANDYSUIT, a wearable force and motion tracking technology. Second, ANDY will develop the ANDYMODEL, a technology to learn cognitive models of human behavior in collaborative tasks. Third, ANDY will propose the ANDYCONTROL, an innovative technology for helping humans through predictive physical collaboration. ANDY will accelerate take-up and deployment by validating its progresses in realistic scenarios. In the first validation scenario the robot is identified with an industrial collaborative robot (i.e. robot=cobot) which adapts its ergonomy to individual workers. In the second validation scenario the robot is identified with an assistive exoskeleton (i.e. robot=exoskeleton) optimizing human comfort and reducing physical stress. In the third validation scenario the robot is identified with a humanoid (i.e. robot=humanoid) offering assistance to a human while maintaining the balance of both.

Keywords: assistive robotics
Temporal predictions in the auditory cortex: neural mechanisms and their specificity across species and stimulus domains (BrainPredictDynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Hong Kong
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 251611.2
EU funding (EUR): 251611.2
Participants: 2
Project status: CLOSED

Following a recent paradigm shift in neuroscience, the brain is often thought to generate active predictions of its environment. Neural predictions of temporal information, in particular, are a current research frontier. A key challenge is to provide a unifying mechanistic explanation of neural expectations ranging from microscopic electrophysiology, via models of interacting populations of neurons, to macroscopic signals observed non-invasively. Auditory and speech perception are the optimal testing ground for studying temporal dynamics of predictive processing in the brain, as most auditory signals only gain meaning as temporal sequences. This project aims at (1) providing a mechanistic model explaining how temporal expectations influence neural activity in auditory cortex across species (rats and humans), and (2) test whether the mechanisms established for simple auditory stimuli generalise to rich, complex and hierarchical structures characteristic of speech stimuli. These research objectives will be addressed in a coherent programme based on well-controlled psychoacoustic and psycholinguistic experiments, combining extracellular electrophysiology in rats and neuroimaging (magneto- and encephalography) in humans with novel analytic tools. By integrating knowledge from disparate fields such as systems-level neuroscience and psycholinguistics, the project will yield novel and unique evidence testing the generality (across species and stimulus domains) and specificity (regarding the proposed neural mechanisms) of the influential theories construing the brain as an inherently predictive organ. Besides its immediate research objectives, the current project is optimised to provide me with training necessary to reach professional independence, complementing my interdisciplinary expertise in an innovative research field across different species and cognitive domains, and consolidating my project coordination, management and leadership abilities.

Keywords: predictive neural processing,temporal expectations,neural oscillations,cross species neuroscience,speech processing