Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanism-based influenza neuraminidase inhibitors as antivirals to combat flu infections (AziFlu)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Influenza neuraminidases are the primary target for anti-influenza small molecule drugs and are retaining glycosidases that form a transient covalent intermediate during substrate hydrolysis. Oseltamivir (Tamiflu) and Zanamivir (Relenza), the two small-molecule anti-influenza drugs used primarily for early onset treatment of flu infections, inhibit influenza neuraminidases competitively (and thus reversibly). The AziFlu ERC PoC proposal is rooted in our finding that N-acyl Oseltamivir aziridines, or Aziflus, inhibit influenza neuraminidase covalently. They block viral outgrowth in an infected cell model. Our compounds are at least as potent as Oseltamivir. Rather than temporarily disabling influenza neuraminidases, our technology acts in an irreversible, permanent, manner. Our drug candidates are selective for influenza neuraminidases over human neuraminidases, and we propose they may be more effective than existing drugs and may also find use as prophylactics and to treat later disease stages. The AziFlu program will develop our mechanism-based influenza neuraminidase inhibition technology and take the first steps to create a start-up company for bringing the technology to market. To strengthen our scientific case (experimental development, A), we will (A-I) optimise our leads by the synthesis and biochemical evaluation of comprehensive sets of focused analogues; (A-II) design a synthetic route to prepare gram-scale quantities of selected leads; and (A-III) develop assays for in vitro and in vivo target inhibition efficacy, target engagement, and viral outgrowth studies. To prepare for the establishment of a spin-out biotech company (business development, B) to take our leads towards the clinic we will (B-IV) strengthen our intellectual property (IP) position; (B-V) analyse the anti-influenza drug market; and (B-VI) create a start-up biotech company to which the IP will be transferred.
Enantioenriched carboxylic acids from alkyl boronic esters through copper catalyzed CO2 fixation (CO2PPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

CO2PPER aims to explore a comprehensive method for the under-investigated catalytic CO2 fixation in asymmetric carboxylation reactions to produce chiral carboxylic acids. Unlike traditional methods that rely on asymmetric hydrogenation of α,β-unsaturated acids and hydroxycarbonylation of alkenes, catalytic CO2 fixation provides a direct and environmentally preferable alternative. Despite recent efforts in creating new chiral ligands to manage reactivity and selectivity, developing a universal catalytic carboxylation using CO2 remains an unsolved problem. CO2PPER proposes a novel approach by employing stable and easily accessible sterodefined alkylboronic esters in metal-catalyzed carboxylations to prepare a broad range of enantioenriched chiral carboxylic acids. The CO2 insertion will be achieved by the use of abundant and inexpensive copper-catalysts, taking advantage of the lowest energy barrier for CO2 insertion into a M-C bond. This project will significantly contribute to the advancement of the CO2-valorization framework and presents an innovative green methodology for chiral carboxylic acid synthesis.

Keywords: co2,asymmetric catalysis
CEO and co-founder of the ecological startup that produces a truly green packaging out of agriculture waste and mycelium. (Yuliia Bialetska)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EU prize
Destination: EU Prize for Women Innovators
Action type: Recognition Prize
Countries involved: Estonia
Call: EIT Category (HORIZON-EIT-2023-WomenInnovatorsPrize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

Yuliia, a visionary innovator hailing from Ukraine, stands as an exemplary woman leader in the world of entrepreneurship. She is the driving force behind S.Lab, an ecological startup passionately committed to revolutionizing the materials industry with a sustainable and eco-conscious approach. At the heart of S.Lab's innovation is the creation of eco-friendly packaging crafted from only two plant-based materials: hemp and mycelium, the root of mushrooms. Yuliia's inspiring leadership has been instrumental in shaping S.Lab's mission to reduce the environmental impact of packaging. Despite facing extraordinary challenges, including the outbreak of war in Ukraine, she founded the startup just two years ago, demonstrating resilience and determination. Yuliia's unwavering commitment to her vision allowed her to relocate and build from the very beginning the production when the war began, showcasing her adaptability and resolve. Under her guidance, S.Lab has emerged as a trailblazing force in the quest for sustainable alternatives. Yuliia's impact goes beyond the boardroom. She has actively championed sustainability through numerous keynote addresses and speaking engagements on panels dedicated to environmental issues and innovations. Her insights and expertise have not only contributed to S.Lab's success but have also inspired a broader audience to embrace sustainable practices. As a woman CEO, Julia embodies the spirit of innovation and leadership. She has not only unlocked scalability for her startup but is also actively developing a groundbreaking technology that will democratize access to their innovative materials. Her dedication to promoting a sustainable future on a global scale is inspiring, as she bridges the gap between consumer demand for eco-friendly products and the availability of alternative materials. Julia's role as a woman innovator underscores the profound impact that women can have in driving positive environmental change through innovation.

Keywords: sustainable packaging,woman entrepreneur,female founder
Advanced mapping, risk assessment and nature-based depollution methods are combined to accelerate the recovery of contaminated soils and ensure that ecological restoration enters mainstream business (EDAPHOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: France,Poland,Greece,Italy,Spain,Germany
Call: Remediation strategies, methods and financial models for decontamination and reuse of land in urban and rural areas (HORIZON-MISS-2022-SOIL-01, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 6992053.75
EU funding (EUR): 6992053.75
Participants: 15
Project status: SIGNED

EDAPHOS proposes a holistic and innovative land management approach to contribute to the Mission “A Soil Deal for EU” and to its specific objective “Reduce soil pollution and enhance restoration”. EDAPHOS will develop a framework for land rehabilitation and ecological restoration of contaminated areas featuring nature-based solutions (NBS) technologies, to accelerate the recovery of contaminated lands to a healthy ecosystem status and making ecological restoration a mainstream business endeavor. EDAPHOS will improve the monitoring of contaminated soils and the understanding of precise pollution sources at selected EU regions by combining robust remote sensing tools and GIS-based methods that will be applied at representative territorial lands. Site-specific risk assessment methods and metrics, based on the TRIAD concept and considering the sources, the pathways, the exposure and effects of soil pollution, will be developed and applied on 7 case studies. EDAPHOS will perform lab and field studies to validate the technological readiness and the cost-effectiveness of NBS as effective remediation strategy for reducing soil contamination in urban, peri-urban and rural settings and land uses. EDAPHOS will assess the environmental, social and economic impacts of selected NBS sites and will develop the most suitable quantitative metrics and KPIs that depict accurately and reliably their integrated socio-environmental performance in both terms of economic benefit (e.g. growth of ecosystem services value, final phytoremediation compounds for further industrial valorization) and cost prevention (e.g. environmental footprint reduction) potentials, along with tailored ecological finance instruments for establishing a self-sustained and replicable EU NBS market. With the aim of providing data-driven tools for forecasting, analyzing and establishing quantitative relationship of multi-scale processes, artificial intelligence techniques will be implemented throughout the project.

Keywords: digital soil mapping ecological risk assessment agro forestry systems european union soil observatory nbs finance
A novel integrated SYstem of Systems streNgthening tEchnical and logistical capacities to ensure better Response to emerGencies by synergIStically addrEssing FRs capability gaps (SYNERGISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Sweden,Netherlands,Poland,Greece,Germany,Spain,Switzerland,Japan,Korea, Republic of,United States,Norway,France
Call: Improved international cooperation addressing first responder capability gaps (HORIZON-CL3-2022-DRS-01, 2022)
Start date: 2023-09-01
End date: 2027-02-28
Duration (months): 42.0
Total project cost (EUR): 5597068.75
EU funding (EUR): 5597066.5
Participants: 24
Project status: SIGNED

SYNERGISE will design, develop, integrate, deploy, test, validate and demonstrate a Novel Integrated Toolkit for Collaborative Response and Enhanced Situational Awareness (NIT-CRES), at the service of response agencies which ensures an upgrade to managing of complex incidents. This will comprise a multitude of tools and services required for: 1) boosting situational awareness and sense-making by offering them the means to autonomously and synergistically perform indoor and outdoor exploration of incident sites towards victim identification whilst receiving at all times information about responders’ position and vitals as well as analyses of passive and active threats and hazards at the area of operations and 2) upgrading collaborative response and incident as well resources management by continuously sharing and updating the common operational picture across deployed teams, among the chain of command and between participating agencies. The NIT-CRES armors the FRs at all fronts by delivering novel, affordable, accepted, and customized response tools and services as part of their operational assets. Notably, the toolkit abides to privacy, ethical, security and legal constraints by design, considers an increased degree of inclusiveness for its operators and its set-up facilitates collaborative response addressing standard operating procedures. The NIT-CRES will be provided at the service of the search and rescue personnel, fire brigades, emergency medical, police and civil protection agencies for extensive testing, training and validation (at component and Toolkit levels) in the framework of a rich Integration, Testing and Validation Activities Programme – of Round Tables (RTs), Collaborative Lab Tests (CLTs), Technical Integration Workshop (TIWS), Component Field Tests (CFTs) and System Field Tests (SFTs) – towards empowering collaborative response and handling of complex incidents to its fullest.

Keywords: autonomous swarm of robots,indoor localisation,vitals monitoring,augmented reality,human machine teaming
Certification Roadmap to Yield an Optimal and Safety methodology of crashworthiness for an integrated cryogenic Tank for liquid hydrogen storAge on board of future aiRcraft (CRYOSTAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Research and Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Italy,United Kingdom,Netherlands,Germany,Poland,Norway,France,South Africa
Call: Crashworthiness of fuselage integrated LH2 storage solutions (HORIZON-JU-Clean-Aviation-2025-01F, 2025)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 5059181.75
EU funding (EUR): 5059181.75
Participants: 15
Project status: SIGNED

Hydrogen is emerging as one of the most promising energy carriers for decarbonizing aviation, offering significant long-term potential for reducing greenhouse gas emissions. However, its implementation faces considerable technical and safety hurdles, particularly in relation to onboard storage and distribution. Hydrogen’s low volumetric energy density, even when stored as cryogenic liquid hydrogen (LH2), implies a need for tanks that are approximately four times larger than those used for conventional aviation fuels. This directly affects aircraft architecture, aerodynamic efficiency, and payload capability. Additionally, LH2 must be maintained at extremely low temperatures—around -253°C—which requires complex, highly insulated, and costly cryogenic tank systems. Hydrogen’s flammability and its capacity to permeate materials that are otherwise impermeable to conventional gases introduce further safety risks and demand stringent engineering countermeasures. The CRYOSTAR project confronts these challenges through the development of a pioneering crash certification methodology for cryogenic hydrogen tanks integrated into the tail section of CS-25 class aircraft. The project’s objective is to engineer, validate, and certify advanced attachment and restraint systems capable of absorbing crash loads while ensuring structural integrity and fuel containment. A comprehensive methodology—combining numerical modeling, physical testing, and credibility assurance frameworks—will support regulatory compliance while reducing development and certification costs. The project aims to define a future certification reference in collaboration with aviation regulators such as EASA, FAA, CAA. CRYOSTAR will achieve Certification Readiness Level (CRL) 5, targeting CRL 6 with flight validation, and Technology Readiness Level (TRL) 5 via full-scale drop tests on equipped fuselage sections, thus laying the foundation for safe and certifiable hydrogen-powered aviation.
ENDORSING SAFEGUARDING, PROTECTION, AND PROVENANCE MANAGEMENT OF CULTURAL HERITAGE (ENIGMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Cyprus,Finland,Belgium,Malta,Spain,Switzerland
Call: Protection of artefacts and cultural goods from anthropogenic threats (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3993500.0
EU funding (EUR): 3993500.0
Participants: 12
Project status: SIGNED

ENIGMA shall achieve excellence in the protection of CGs and artefacts from man-made threats by contributing to identification, traceability, and provenance research of CGs as well as by safeguarding and monitoring of endangered heritage sites. ENIGMA objectives are designed to help the involved stakeholders better respond to this complex, and multi-dimensional problem, and leverage active collaboration by fostering and enabling interlinking of databases, and evidence-based deployment of preventative measures.

Keywords: anthropogenic threats,identification,traceability,provenance
Quantum Materials for Integrated nanoscale Neuromorphic computing Devices (Q-MIND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 3
Project status: SIGNED

In the last years, artificial intelligence (AI) has driven critical advancements in sectors like healthcare, autonomous vehicles, entertainment, and finance, transforming science, technology, and our daily lives. Deep-learning neural networks (NNs) are central to many of these AI systems due to their ability to learn complex patterns, largely owing to their nonlinear activation function. However, NNs are typically built on traditional von Neumann architectures, where separate memory and processing units result in inefficiencies, leading to high costs and energy consumption as AI models grow more complex. This has boosted great interest in unconventional computing architectures, like neuromorphic computing, which mimics the brain's design for more sustainable and scalable AI systems. Photonics presents a promising solution here, offering unmatched speed, parallel processing, and energy efficiency that outperform traditional electronic chips. Despite this potential, realizing all-optical NNs presents considerable technical challenges. Key obstacles include weak nonlinear optical interactions, which are essential for creating complex input-output relations in NNs via nonlinear activation functions. In turn, plasmonic systems can provide stronger nonlinearities, but ohmic losses hinder their application. Q-MIND aims pioneer a radically-new nanometer-scale, ultrafast and energy-efficient technology to address current limitations in neuromorphic computing. Specifically, it will integrate phonon-polaritons—quantum hybrids of light and lattice vibrations—in 2D materials, which can guide light at the nanoscale with minimal energy loss, and heavily doped semiconductors, which will provide tunability and dynamic control of nonlinear interactions. Both materials' nonlocal behavior will be key to unlocking novel nanoscale nonlinear processes at the heart of Q-MIND's vision. Q-MIND aligns with EU and UN priorities on sustainable development and AI and quantum technologies.

Keywords: nonlinear optics,phonon polaritons,heavily doped semiconductors,nonlocality,hydrodynamic,two dimensional materials,optical neural networks,hybrid photonics plasmonics,field effect
RNA biology and neuroglial function: resolving the cellular and subcellular transcriptome in myotonic dystrophy brains, towards new brain gene therapy (NEUROGLIOSOLVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

RNA biology is critical for the molecular orchestration of the interplay between specialized brain cell types, and disrupted RNA processing, can cause human disease. A prime example is Myotonic Dystrophy type 1(DM1), a multisystemic disorder caused by the expansion of a non-coding trinucleotide DNA repeat and that involves cognitive impairment and behavioral changes. Molecular pathogenesis is driven by the nuclear accumulation of RNA foci, which sequester RNA-binding proteins that regulate splicing, polyadenylation and subcellular localization of downstream transcripts. However, we do not know the cell populations, molecular pathways and cell-cell interactions primarily affected in the brain. A critical question to develop effective molecular therapies. My host laboratory developed a unique mouse model of DM1 that mirrors the spatiotemporal expression of toxic RNA and relevant brain phenotypes. Using these mice, I will fill three knowledge gaps:(1) I will employ advanced spatial transcriptomics to unravel the vulnerability of diverse cell types throughout brain development and aging;(2) I will use the TRAP technology to uncover subcellular transcriptomic abnormalities in specialized neuron-astrocyte contacts and identify pivotal disease intermediates of neuroglial miscommunication;(3) I will use my expertise in AAV-mediated brain gene delivery to test the capacity of engineered protein decoys, developed in my host laboratory, to release the RNA-binding proteins sequestered in brain cells and correct the behavioral, molecular neurobiological deficit in DM1 mice. Through the integration of cutting-edge transcriptomics with a new focus on synaptic neuroglial communication, I will elucidate DM1 brain pathogenesis with unprecedented spatiotemporal resolution, and offer a framework to understand other conditions mediated by toxic RNA repeats, for which DM1 serves as a paradigm. Simultaneously, my project will enhance our understanding of RNA biology in the brain.

Keywords: myotonic dystrophy,trinucleotide repeat expansion,toxic rna,spatial transcriptomics,gene therapy,neuroglia communication,rna binding proteins,splicing,synapse