Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synthetic Circular RNA therapeutics for prevention of sepsis-associated organ failure (CIRCLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1499946.0
EU funding (EUR): 1499946.0
Participants: 1
Project status: SIGNED

Reversing organ failure, a leading cause of death in sepsis, requires specific modulation of biological pathways in endothelial cells, which is currently not possible with the existing drugs available. Employing RNA-based drugs to control protein expression could offer a novel therapeutic strategy in the fight against sepsis. Circular RNAs (circRNAs) are a new class of non-coding RNAs with a unique closed-loop structure that could help address the current limitations of the RNA drugs in the disease context and open new therapeutic avenues. Therapeutic delivery of engineered synthetic circRNAs can allow taking full advantage of their unique features and functions, including increased intracellular stability, the ability to affect multiple biological pathways by sponging microRNA or proteins, and their potential for cellular context-specific control of protein expression via internal ribosome entry site (IRES)-mediated cap-independent translation. I recently co-developed methods for the circularization and purification of large synthetic circRNAs, and pioneered their use for robust and stable protein expression in eukaryotic cells, to address the short half-life of mRNA in biological systems. I also synthesized a new type of degradable polymers that enable tissue and cell-type selective delivery of large RNAs with low toxicity. Building on those findings, CIRCLE aims to expand the toolbox of therapeutic RNAs by engineering novel synthetic circRNAs for modulation of protein expression in sepsis (WP1 and WP2) and investigate the potential of synthetic circRNA delivery for developing RNA-based pharmacological intervention to reverse sepsis-associated lung and kidney failure (WP3 and WP4). By addressing an important gap in the knowledge on the utility of circRNAs for translational research the scientific impact of CIRCLE will extend across the research fields of pharmaceutical sciences, synthetic biology, and medicine.

Keywords: circular rna,nucleic acid delivery,polymeric nanocarriers,sepsis,endothelial dysfunction,drug delivery systems,non viral gene therapy
reGeneRative bone Implant for the treatment of hip dysPlasia (GRIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

GRIP develops a personalised, 3D-printed regenerative bone implant as a treatment for hip instability (hip dysplasia) and its commercialisation strategy. Osteoarthritis (OA) of the hip is a painful and debilitating condition and hip dysplasia is one of the two main causes. The currently most common surgical methods to correct the dysplasia involve the re-alignment of the hip socket (osteotomy) or the insertion of a bone graft to enlarge the socket (shelf arthroplasty). While the osteotomy is invasive, the shelf arthroplasty requires donor tissue. In addition, both procedures only have limited success rates. GRIP implants overcome the current shortcomings of these methods and provide a novel personalized implant to treat hip dysplasia. GRIP will provide patients and surgeons with an easy to use, one-step and cost-effective regenerative device, therefore overcoming the significant drawbacks with current treatments for hip dysplasia. The GRIP implants will be precisely fabricated from a flexible bone-inducing biomaterial through a process both developed and established within the ERC-CoG “3D-JOINT” project. This will ensure a perfect fit, resulting in optimal integration and durable restoration of the hip socket, as well as obviating the need for complex and invasive osteotomy surgeries. GRIP implants will revolutionise the treatment of hip dysplasia as they provide a stable, long-term, and regenerative solution that will fully integrate with the host bone tissue. Moreover, the regenerative nature will also make this a potential treatment option for younger (paediatric) patients. As GRIP will transform the treatment of hip dysplasia and will improve long-term health and well-being of both human and veterinary patients the economic value and the route to the market for the GRIP technologies will be explored.
Remote Ethnography of Xinjiang Uyghur Autonomous Region. Methodology and Research Capacity Building (REMOTE XUAR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Belgium,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1493487.5
EU funding (EUR): 1493487.5
Participants: 3
Project status: SIGNED

Remote Ethnography of Xinjiang Uyghur Autonomous Region. Methodology and Research Capacity Building This project seeks to develop a methodology of remote ethnography, to collect data and produce analysis of Xinjiang Uyghur Autonomous Region (XUAR) in the Central Asian northwest corner of the People's Republic of China. It aims to establish a consolidated research group, train the researchers in methods relevant for remote ethnography and through their interactions develop both a remote ethnography of XUAR and a sound methodology of remote ethnography for areas with limited access. The motivation for this is that the developments in XUAR and the abuse committed against the muslim minorities in the region have become major geo-political issues central for the EU and European countries choices of future engagement and cooperation with China and the US. At the same time, access to XUAR itself has become extremely limited and the information gained from the area often heavily politically biased, fragmented and unreliable. Further, the rise of surveillance, securitisation and authoritarianism world wide suggest that such places will increase rather than decrease over the next decades. It is therefore both important to gather reliable and deep knowledge of XUAR and to develop solid methodological tools for approaching such closed state or privately controlled areas. Through this project Palacky University Olomouc (UPOL) along with the two partner universities (Würzburg Universität and Université Liberté Bruxelles) will become important interconnected hubs in a strengthening network of researchers on XUAR, will place UPOL on the map as a force in XUAR studies and in methodological innovation of remote ethnography and will provide reliable information on the region to media, policy makers NGOs and other non-academic stakeholders including the Uyghur diaspora community to whom a degree of ownership of the knowledge produced about them and their region must be reinstated.

Keywords: china,xinjiang,uyghur,remote ethnography,online ethnography,narrative interviews,remote sensing,surveillance,securitisation
AcceLerated PreCision Tests of Lepton UniversAlity (ALPaCA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2029-03-31
Duration (months): 78.0
Total project cost (EUR): 1384543.0
EU funding (EUR): 1384543.0
Participants: 1
Project status: SIGNED

The Standard Model (SM) of particle physics describes most fundamental phenomena extraordinarily well, but unresolved questions such as the matter-antimatter asymmetry remain. New Physics (NP), able to resolve these questions, has not been found in direct searches yet, so it must be either extremely rare or manifest at higher energies that can only be probed by precision SM measurements. Lepton flavor universality (LFU) is one of the most precise predictions of the SM, but discrepancies with measurements have emerged in decays of B hadrons. Unambiguously establishing the presence of LFU breaking effects is therefore one of the most vital and timely challenges in HEP. However the current experimental precision is not sufficient for a discovery due to the limited size of data sets. Therefore, the LHCb experiment at CERN is being upgraded to measure B hadrons at higher rates. But at these rates, efficient selection of signals requires exceptional computing demands. CPU-based systems no longer meet these demands, so real-time selection constitutes a major bottleneck. The Allen system, that I have pioneered and led from proof-of-concept to the new LHCb baseline implementation, solves this by using graphics processing units, and even provides a large head-room in computing resources. With ALPaCA I will build a team to demonstrate that the experimental precision of LFU observables required to establish the presence of NP is reached by using accelerated real-time analysis systems. We will: 1. Enhance Allen using the extra computing resources to increase the data samples for LFU observables by a factor two. 2. Test LFU in ratios of branching fractions of b -> c l nu transitions with electrons for the first time at LHCb. 3. Characterize NP by measuring angular observables of b -> c tau nu transitions at LHCb. 4. Direct the design of future experiments and facilities by unlocking new computing potential.

Keywords: lepton flavor universality b flavor anomalies real time analysis systems heterogeneous computing
Skill Performance Estimation from cARdiac Signals (SPEARS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

In any learning situation, be it math education, language learning or sport training, different learners have different abilities, motivations and capacities at any given time. Thus, an optimal learning can only be achieved with personalized training solutions, dynamically adapted to each learner’s cognitive and/or physical states. The scientific literature showed that such states could be estimated from Cardiac Signals (CS). In ERC PoC SPEARS, we thus propose to redefine consumer training apps, by enabling them to propose personalized and adaptive training plans according to an estimation of their users’ cognitive and/or physical states from their CS measured with consumer grade sensors, e.g., smartwatches. The outcome of ERC project BrainConquest should enable us to tackle this challenge. Indeed, in BrainConquest we explored such a personalized training approach for users of Brain-Computer Interfaces (BCI). In doing so, we developed Machine Learning (ML) and Signal Processing (SP) algorithms to estimate users’ mental states and predict their upcoming performances from their brain and physiological signals, including CS. In SPEARS, we thus aim at adapting, improving and assessing BrainConquest ML & SP algorithms, initially designed for BCI performance prediction from research grade brain and CS sensors in the lab, to predict cognitive and physical performance from consumer grade CS sensors in the wild. Such algorithms could be used for adaptive training apps in education, cognitive training for healthy aging or sport training. We will then explore a commercial application of this technology for sport training in particular, in collaboration with the startup Flit Sport, which sells an app for providing personalized training exercises for endurance sport athletes, based on their past performances and ML. By integrating our CS-based prediction into Flit Sport training app, we should design optimally personalized training solutions for millions of runners worldwide.
Innovative methodology to prevent and mitigate diffuse pollution from urban water runoff (WATERUN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Germany,Italy,Denmark,France,Jordan,Switzerland
Call: Preventing and managing diffuse pollution in urban water runoff (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 3974187.5
EU funding (EUR): 3970437.5
Participants: 15
Project status: SIGNED

WATERUN project aims to develop an innovative methodology to contribute to the implementation of urban water runoff management plans in cities based on the Water-Sensitive Urban Design concept. This methodology will provide preventive and mitigation solutions and best management practices adopting a holistic perspective (from source identification to remediation strategies) for diffuse water pollution control in urban catchments. The target is to transform the urban water runoff management by the development of identification, planning and risk-based tools and new working procedures (guidance), counting on the early involvement of the main urban water management and governance actors (co-creation process) to ensure a wider and faster adoption. Three case studies (city of Santiago de Compostela, city of Aarhus and city of Amman) have been chosen to obtain data and to elaborate, perform and validate the proposed WATERUN methodology. These case studies have been selected according to different climate conditions, land use and level of implementation of measures for diffuse pollution, in order to validate the tools in different scenarios. Key stakeholders as RTO, industry, public authorities, urban planners and citizens will participate in a continuous co-creation process from a multi-disciplinary approach ensuring that decisions for urban water runoff management are made with complete comprehension of environmental, social and economic dimensions. In addition to providing solutions for sustainable urban water management, the WATERUN methodology will allow to gain advanced knowledge on diffuse water pollution in cities in a climate change context, thus contributing to protect water bodies and the environment, and ensuring high water quality for all.

Keywords: diffuse pollution,urban water runoff,stormwater,water management,green infrastructure,climate change,monitoring,modelling,decision support system
Flat Bands for Quantum Metrology (FLATS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Germany,Belgium
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 3875747.5
EU funding (EUR): 3875747.5
Participants: 7
Project status: SIGNED

The ultimate limit on the accuracy of any measurement is set by quantum mechanics, this also means that quantum effects can be used in metrology and sensing to go well beyond any classical approach. For classical systems, statistical error is proportional to 1/sqrt(N) with N the number of measured particles. Measurements in quantum systems can overcome this limit and reach the Heisenberg limit proportional to 1/N. However, quantum standards and sensors are challenging to put in practice and their working conditions are nowadays intrinsically incompatible (e.g. magnetic field and superconductivity). Therefore, limiting their reach in terms of users and their development as accurate and enhanced quantum technologies. The vision we propose in FLATS is to use twisted bilayer graphene as a multiphenomena platform to develop present electrical quantum metrology standards, working under compatible conditions, and to develop the new generation of metrological sensor, going beyond the International System of units (SI). Their common platform will allow their integration as a single multi-use on-chip quantum lab. To achieve this, we will first create a European twistronics plateform for an unprecedented control of the relative angular alignment between graphene/BN layers. We will develop novel and original quantum electrical standards with twisted heterostructures. Our on-chip metrological quantum lab also enables the implementation of metrological sensors beyond the SI. This will be the first step towards quantum-enhanced measurements for metrological applications.

Keywords: metrology bilayer graphene flat bands mesoscopic physics
Controlled Local Heating to Crystallize Solution-based Semiconductors for Next-Generation Solar Cells and Optoelectronics (LOCAL-HEAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Solution-processed semiconductor thin-films have recently emerged as promising candidates for optoelectronic devices such as light-emitting diodes (LEDs), sensors and solar cells. One example is hybrid perovskite films that are processed inexpensively by crystallization from a solution and have the disruptive potential for efficient energy production and consumption. However, current crystallization methods from solution often result in uncontrolled film growth with ragged, degradation-prone grain boundaries. The lack of quality materials with large, controlled grains holds back solution-based semiconductors. The core hypothesis of LOCAL-HEAT is that controlling the fundamental crystallization kinetics of semiconductor films, when transitioning from the liquid precursor to the final solid-state, governs ultimate performance and long-term stability. This is key to creating materials that are: a) sustainable, b) stable and c) show highest performance. To achieve this challenging goal, I will control the crystallization kinetics of liquid multicomponent semiconductor inks by turning light into localized heat packages to cause confined supersaturation. This will induce seeds to crystallize the liquid precursor into high-quality films. Local heat will be realized by developing two methods: a) laser annealing by a tunable light pattern, projected on a liquid precursor film, and b) thermoplasmonic heating of plasmonic nanoparticles acting as antennas to turn incoming light into a localized heat nanobubble within a liquid ink. Achieving sustainable materials with highest quality crystallization will enable perovskite solar cells with performances >26% and stabilities of >30 years. Consequently, it will also revolutionize solution-processed semiconductors in general. LOCAL-HEAT will thus enable key technological applications in optoelectronics, e.g., solar cells, LEDs and scintillation detectors, and beyond.

Keywords: crystallization,scalability,optoelectronics,solar cells,thin films
Superwettability-enhanced Electrocatalysis (SuperElectro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

In recent years, worldwide efforts to tackle climate change have resulted in immense momentum towards renewable energy research. Despite renewables (i.e. photovoltaic) achieving cost parity vs. fossil fuels (32-44$/MWh vs. 44-152$/MWh), implementation remains limited. One persistent challenge is intermittency (i.e. inconsistent energy supply by seasonal/daily cycles). Amongst promising energy storage methods (i.e. Li-ion batteries, hydrostatic, etc.), electrocatalytically-generated hydrocarbons pose numerous advantages. They are 1) non-polluting, 2) benign aqueous compositions, 3) earth-abundant electrode materials, and 4) carbon-neutrality / carbon-negative via carbon dioxide reduction. However, there is still limited control over the gaseous pathways in gas-involving electrocatalysis. This limitation negatively influences both reactant and product flux, affecting conversion efficiency. From a physical perspective, electrocatalysis is a multi-phase process where (liquid) immersed electrodes (solid) interact with reactants/products (gas). Integration of concepts in wettability is thus beneficial. Surface superaerophilicity refers to its strong affinity (-Super) for air/gases (-Aerophilicity). With superaerophilicity, microscopic gas-layers on surfaces (i.e. plastrons) provide highly efficient reactant/product gas transport pathways. In this project, I will investigate design principles for “Superwettability-enhanced Electrocatalysis (SuperElectro)”. The primary goal is to decouple wettability and electrocatalytic activity. Achievements in electrocatalytic-enhancements (i.e. current density, conversion efficiency, etc.) will thus be universal. The choice of electrode catalyst becomes independent from wettability as plastrons provide alternative product and reactant pathways. Electrocatalysis is vital towards a sustainable adoption of renewable energy technologies. The success of this work impacts the future of our energy industries and green-friendly societies.

Keywords: wetting,electrocatalysis,nanomaterials,bubble,plastron,superamphiphobic,superomniphobic