Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Therapeutic and Biomarker Potential of long non-coding RNAs in Vascular Disease (NORVAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1493125.0
EU funding (EUR): 1493125.0
Participants: 2
Project status: CLOSED

The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining cardiovascular homeostasis. Recently, non-coding RNAs, especially the ones with antisense capabilities such as microRNAs or ‘natural antisense transcripts’ (NATs) have received much attention. They have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. This current proposal describes the development of novel diagnostic and therapeutic strategies to limit the burden of cardiovascular disease in general, and abdominal aortic aneurysms as well as carotid stenosis and subsequent stroke in particular. Using transcriptomic profiling techniques on human diseased tissue samples, we have identified two NATs (SLFNL-AS1 and NUDT6) as novel crucial regulators of smooth muscle cell survival via targeting CTPS1 and the fibroblast growth factor 2 (FGF2) in the vascular system. We are using disease-relevant experimental in vivo models (rodents and LDLR-/- mini-pigs) to functionally assess how inhibition of these two NATs influences aneurysm progression and atherosclerotic plaque vulnerability. One focus of our studies is to utilize local delivery mechanisms for non-coding RNA modulators, such as drug eluting balloons and stents, to enhance the translational feasibility of our findings. Furthermore, we have access to unique human plasma material from patients with early and advanced forms of aneurysm disease, enabling us to investigate the biomarker value of non-coding RNAs in recognizing patients with acutely ruptured aneurysms, as well as predicting the future risk of rupture.

Keywords: non coding rna,microrna,abdominal aortic aneurysm,stroke
Understanding Type Ia SuperNovae for Accurate Cosmology (USNAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-08-31
Duration (months): 78.0
Total project cost (EUR): 1437188.0
EU funding (EUR): 1437188.0
Participants: 1
Project status: SIGNED

With this proposal I aim at removing astrophysical biases in SN cosmology that limit improvements in the derivation of properties of the dark energy (DE). DE is the cause of the recent acceleration of the expansion of the Universe and accounts for ~70% of its total energy. The initial discovery based on distance measurements from Type Ia Supernovae (SNeIa) has since been confirmed with several independent probes. Today, the goal of cosmology is to understand the nature of DE, and SNeIa remain a central probe for this endeavor. However, the nature of SNeIa remains largely unknown, which limits our ability to accurately trace the properties of the Universe. The proposed research program focuses on solving this problem. The project takes place at the frontier between astronomy, cosmology and data-science, and consists of three main interconnected work-packages: 1. Understand the influence of the interstellar dust on the SN reddening, based on the unique combination of ground based spectrophotometry and high-resolution HST (space) UltraViolet-photometry; 2. Map SN progenitor variations across environments through next-generation large-scale transient surveys; 3. Combine the knowledge of the two former packages into a unique SN framework capable of adapting as the Universe evolves across time and distance. This will be used to derive accurate measurement of the Hubble constant and the dark energy equation of state parameters. The project is made possible by a combination of state-of-the-art SN and galactic datasets from ZTF, SNfactory and an ongoing Hubble Space Telescope program of up to 136 orbits (PI: Rigault). The HST data will enable the first measurement of stellar-age and the interstellar dust at the SN location.

Keywords: supernova
Death and Life of Catalysts: a Theory-Guided Unified Approach for Non-Critical Metal Catalyst Development (DeLiCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1999524.0
EU funding (EUR): 1973438.04
Participants: 2
Project status: CLOSED

Most of the developments in catalyst are still based on serendipitous and trial-and-error approaches, in which potential systems can be overlooked simply because of the sub-optimal conditions of the initial activity assessment. Mechanistic and kinetic studies could provide a framework for a more adequate assessment of new catalysts, but such rigorous experiments are not practical for general catalyst discovery. Modern chemical theory and computations hold a promise to be employed in new efficient theory-guided approaches for rational catalyst and process development. The main aim of DeLiCat is to formulate a hierarchical computational strategy for the design and synthesis of new non-critical metal-based catalysts for sustainable chemical transformations. New, durable and cheap, yet, highly active and selective tailor-made catalyst for hydrogenation of carboxylic acids and their esters as well as for acceptorless dehydrogenation of alcohols will be developed. The research will follow an innovative strategy combining advanced chemical theory, computational screening and experimental approaches from the fields of homogeneous and heterogeneous catalysis in an efficient knowledge exchange loop. Computer simulations will reveal complex reaction networks that determine the “death” and the “life” of catalyst systems. These insights will be used in targeted design of novel multifunctional catalyst systems to direct the selectivity of the reaction network and to prevent deactivation paths. Complementary experimental studies will guide and validate the theoretical predictions. DeLiCAT represents a leap forward in unified first principles-guided catalyst design for liquid phase chemical transformations. The new theoretical concepts, methodological advances as well as the novel superior catalyst systems developed here will be applicable in various areas including biomass valorization, homogeneous and heterogeneous catalysis as well as hydrogen technology.

Keywords: catalyst design,cooperative catalysis,sustainable chemistry
Integrated innovative metallurgical system to benefit efficiently polymetallic, complex and low grade ores and concentrates (INTMET)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Spain,Spain,South Africa,Austria,Austria,Finland,Poland,Serbia,Poland,Romania,France,Portugal
Call: New metallurgical systems (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 7834976.25
EU funding (EUR): 7834976.25
Participants: 14
Project status: CLOSED

The INTMET approach represents a unique technological breakthrough to overcome the limitations related to difficult low grade and complex ores to achieve high efficient recovery of valuable metals (Cu, Zn, Pb, Ag) and CRM (Co, In, Sb). Main objective of INTMET is applying on-site mine-to-metal hydroprocessing of the produced concentrates enhancing substantially raw materials efficiency thanks to increase Cu+Zn+Pb recovery over 60% vs. existing selective flotation. 3 innovative hydrometallurgical processes (atmospheric, pressure and bioleaching), and novel more effective metals extraction techniques (e.g. Cu/Zn-SX-EW, chloride media, MSA, etc) will be developed and tested at relevant environment aiming to maximise metal recovery yield and minimising energy consumption and environmental footprint. Additionally secondary materials like tailings and metallurgical wastes will be tested as well for metals recovery and sulphur valorisation. The technical, environmental and economic feasibility of the entire approaches will be evaluated to ensure a real business solution of the integrated INTMET process. INTMET will be economically viable thanks to diversification of products (Cu, Zn, Pb), high-profitable solution (producing commodities not concentrates), with lower operation and environmental costs (on-site hydroprocessing will avoid transport to smelters) and allowing mine-life extension developing a new business-model concept based on high efficient recovery of complex ores that will ensure EU mining industry competitiveness and employment. INTMET is fully aligned with EIP-RM validated in the PolymetOre Commitment where most of INTMET partners take part on and the market up-take solutions are guaranteed by an exploitation from industrially-driven consortia composed by 3 Mines, 2 SMEs (AGQ -waste&water tech provider; MINPOL -policy & exploitation expert), 2 tech providers (OUTOTEC and TR) and 5 complementary RTD´s with expertise in leaching and recovery metals processing

Keywords: ores,minerals,hydrometallurgical processing,pressure leaching,atmospheric leaching,bioleaching,metal recovery,low grade ores,polymetallic ores
Magic angle coil spinning NMR on living voxels - LiVoX (LiVoX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-09-01
End date: 2017-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

LiVoX will make our NMR microchip sensor market-ready for novel applications such as foodstuff testing, compound screening for example on cell-based assays, or biopsy monitoring for hospitals. By turning NMR sensors into consumables, LiVoX will achieve a paradigm shift that will open up these new markets. We are convinced that the sensors will be readily accepted by the market, since they already work with established and installed NMR hardware, and provide dramatically increased NMR measurement sensitivity. LiVoX will take a mass-producible NMR microchip sensor that is currently at technology readiness level (TRL) 6 at a university laboratory, and scale up the manufacturing towards wafer-scale mass production, by outsourcing the majority of the manufacturing steps. LiVoX will implement quality control procedures for production and sensor function, and will perform extensive beta testing at application sites, to drive the microchip sensors right up to commercialisation readiness at TRL 9. It is the clear goal of LiVoX to transfer the microchip sensor manufacturing process to a startup company at the end of this one year ramp-up period. LiVoX will remove the last barriers that remain for introduction of the microchip sensors into the marketplace.

Keywords: microchip nmr sensor,consumable sensor,ramped up wafer scale manufacturing
INNOVATIVE FUNCTIONAL PAINT FOR AIR PURIFICATION (AIRLITE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy,United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 1707728.75
EU funding (EUR): 1195410.13
Participants: 2
Project status: CLOSED

AM Technology Ltd is an SME founded with the objective of successfully developing and commercialising innovative functional paints based on AIRLITETM technology, an air purification technology based on the photocatalytic oxidation effect of Titanium dioxide (TiO2). The paints based on AIRLITE are capable of transforming any architectural surface into a natural air purifier, using only the energy of light, making no noise and requiring no maintenance. AIRLITETM can be used for both indoor and outdoor environments, making it a real and effective solution for effectively solving poor air quality issues at a reasonable cost. AIRLITE is a unique technology in the sense that it brings together an exceptional performance in terms of air purification (well above any other photocatalytic paint) and some other additional characteristics and advantages: AIRLITE reflects the hot component of sunlight, preventing the passage of excessive heat, which remarkably reduces the energy consumption needed to cool indoor environments. AIRLITE eliminates mould, bacteria and bad smells, and repels dirt. AIRLITE generates a high concentration of natural disinfectants which kill more than 99.99% of bacteria in the treated environment. Other advantages: Safety (is completely free of Volatile Organic Compounds (VOCs)), high durability (lifetime extended by twice that of normal paint resulting in less repainting costs), and a very low price (6 times less than existing photocatalytic paints). On their way to the market, AM Technology have developed some preliminary AIRLITE based products, and conducted an early stage commercial validation phase with them. This validation demonstrated the business viability of the project and identified the tasks and activities that need to be undertaken (from a technical and business/exploitation point of view) to successfully introduce AIRLITE into the market. Those tasks and activities are presented in this proposal.

Keywords: paint,coating,air quality,air purification,anti pollution,energy efficiency,functional paint,photocatalytic,titanium oxide
Detergent free steam cleaning system for modular conveyor belts in the food industry (Steammatic)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

REA STEAM CLEANING has developed since 1986 advanced steam cleaning systems, and thanks to its expertise has become a market leader. Steam has some very specific properties that makes it a very efficient and environment friendly cleaning media for an infinity of applications A major market for our company has become the food industry for sanitization and infection control to remove listeria, e-coli, salmonella and other pathogenic microorganisms on food processors equipment. Nowadays, most of major food industries are using REA mobile steam cleaners. REA started to address, in years 2000, the issue of conveyor belt cleanings. Conveyor belt are extremely important in food industry for the transport of the ingredient and aliments all along the production cycle, and they are a main cause of bacteria related problems. We focused first on small, flat belts with semiautomatic systems, and the first results were encouraging enough to convince us that fully automatic steam cleaning systems, allowing to clean and disinfect during production (which is not possible with any of today’s existing systems) would high a very high impact on the market. In the meantime, our reputation in the food industry and focused sales and marketing actions, were such that more and more food processing companies are reverting to us, looking for a solution of their most difficult belts to clean: the long modular belt Those numerous enquiries permitted us to define the specifications of the ideal cleaning system that must be able to work on this specific type of belt, which is becoming the most common in food plants. The ideal equipment must be compact, able to run during production, limit the use of water and totally suppressed the use of chemicals This is the basic concept of our project, for which we have identified a market and a selling strategy, but that requires the construction of a working prototype, further tests, and studies regarding market exploitation, sales and marketing strategies

Keywords: food industry,belt cleaning,detergent free,steam
CellPrintArray – on-demand nano-scale printing of live cells and compounds for miniaturized cell screening applications (CellPrintArray)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The goal of this ERC-PoC project is to develop a prototype system that will enable the addition of libraries of drugs and biochemical molecules, reagents and cells from a 96 source plate directly to individual compartments of the target Droplet Microarray (DMA). The system should have controlled atmosphere (CO2, humidity, temperature) and should allow for dispensing controlled volumes (3-500 nL per experiment) and cell numbers (1-100 per experiment) into individual droplets. We aim to create and evaluate this system for applications commonly performed in pharmaceutical companies and screening centers to enable them to perform miniaturized and more predictive high throughput screenings using physiologically relevant cells such as primary cells, stem cells, biopsy-derived cells and other scarce cell types. The system should allow high-throughput screenings with patient derived cells and therefore will open new possibilities in drug discovery and personalized medicine.

Keywords: cell screening,miniaturization,automation,superhydrophobicity,personalized medicine
De novo design of an UpConverting metalloProtein (UCLnProt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Borghesani (bioinorganic chemistry and spectroscopy) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Borghesani with new and cutting-edge research training.

Keywords: peptide design,lanthanides,up conversion