Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Controlling Large Language Models (Control-LM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Large language models (LMs) are quickly becoming the backbone of many artificial intelligence (AI) systems, achieving state-of-the-art results in many tasks and application domains. Despite the rapid progress in the field, AI systems suffer from multiple flaws inherited from the underlying LMs: biased behavior, out-of-date information, confabulations, flawed reasoning, and more. If we wish to control these systems, we must first understand how they work, and develop mechanisms to intervene, update, and repair them. However, the black-box nature of LMs makes them largely inaccessible to such interventions. In this proposal, our overarching goal is to: *Develop a framework for elucidating the internal mechanisms in LMs and for controlling their behavior in an efficient, interpretable, and safe manner.* To achieve this goal, we will work through four objectives. First, we will dissect the internal mechanisms of information storage and recall in LMs, and develop ways to update and repair such information. Second, we will illuminate the mechanisms of higher-level capabilities of LMS to perform reasoning and simulations. We will also repair problems stemming from alignment steps. Third, we will investigate how training processes of LMs affect their emergent mechanisms and develop methods for fine-grained control over the training process. Finally, we will establish a standard benchmark for mechanistic interpretability of LMs to consolidate disparate efforts in the community. Taken as a whole, we expect the proposed research to empower different stakeholders and ensure a safe, beneficial, and responsible adoption of LMs in AI technologies by our society.

Keywords: language models,interpretability
A SUstainable integrated Route to convert waste PLAStics to H2 and low carbon liquid fuels (SURPLAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-07-31
Duration (months): 35.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 1
Project status: SIGNED

The management and disposal of plastic waste is an ever increasing problem with the EU alone generating more than 29.1 million tons of post-consumer plastic waste each year. The main aim of the proposed project is to deliver an integrated solution utilizing plastic waste to generate low carbon H2 and low carbon liquid fuels providing a decarbonisation route for the stationary power generation and transport sectors toward a clean energy and sustainable future. Thus, SURPLAS is in line with the European Union's Strategy for Plastics in a Circular Economy and serves the ultimate goal of the recently announced Green Deal toward an energy transition to a low or even zero carbon economy to effectively combat climate change. In specific, different types of plastic waste will be processed, characterized and gasified to produce syngas at high hydrogen yields with adjusted H2/CO ratios and low tar formation, employing optimum operating parameters and catalysts to improve the gasification performance. At the same time, SURPLAS is proceeding one step forward with the conversion of gasification derived syngas mixtures toward Fischer-Tropsch (FT) liquid synthetic fuels using advanced in terms of synthesis and composition nanocatalysts. Thus, regarding the FT synthesis process, SURPLAS is aiming to optimize process conditions and identify superior catalysts to enhance the activity and selectivity of FT process to diesel and gasoline fractions (low carbon fuels) for maritime and heavy duty vehicles applications. The final objective of the proposed project is to elaborate reliable energetic and feasibility studies for real-scale SURPLAS processes (kW and MW scales) and to investigate their potential market prospects and business cases.

Keywords: waste plastics energy recovery gasification syngas fischer tropsch synthetic liquid fuels low carbon transportation fuels heterogeneous catalysis process systems design feasibility study
ElectroChemiLuminescence doctoral network for early sepsis diagnosis (ECLectic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Spain,France,Ireland,Netherlands,Germany,United States,United Kingdom,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2751078.86
EU funding (EUR): 2639419.2
Participants: 19
Project status: SIGNED

Sepsis and bacterial infections are leading causes of death in hospitals with more than 500 thousand casualties yearly. The early infection diagnosis as well as early microbial treatment are of great importance. However, effective treatment is hampered by misuse of antimicrobial drugs, leading to resistant bacterial pathogens, high risks of infection recurrence and patient mortality as well as increased medical costs. Thus, there is a need for fast and reliable sensors systems for diagnosis of sepsis reducing the time-to-report from several days or weeks to hours, facilitating the early delivery of appropriate anti- bacteria therapy. ECLectic network will address the worldwide problem of sepsis and bacterial infection by developing the next generation of sensing platforms, providing entirely new diagnostic paradigms. ECLectic will develop, optimize, and assess novel biosensors based on electrochemiluminescence by combining different nano- and microstructured materials and fluidic devices. ECLectic will ultimately result in novel fast and reliable point-of-care devices with applications of bacterial infection analysis, monitoring of disease recurrence, and progression. It will close the gap between innovative research in the field of nanostructured materials and their application in biosensing technology. ECLectic will create a Center of Excellence in Europe for the training of young researchers in the research and development of sensing platforms for bacterial infection and sepsis. By training, ECLectic will provide highly skilled European researchers for academic research in biodetection, materials, microfluidics and electrochemistry as well as for the European biosensor industry. ECLectic will generate a flexible cluster of excellent young researchers ready to tackle the European challenges in the development of novel detection platform for bacterial infection. They will be trained well to become leaders in industrial as well as academic research and development.

Keywords: electrochemiluminescence,electrochemistry,sensors,sepsis,nanomaterials
Design of Nucleic Acid-Templated Ordered Protein Assemblies (DNA-TO PAss)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1499711.0
EU funding (EUR): 1499711.0
Participants: 1
Project status: SIGNED

Here I propose to create a new class of designed nanomaterials that will combine the advantageous features of protein design and DNA nanotechnology: nucleic acid-templated protein assemblies. I propose three different approaches that all utilize the addressability of nucleic acids on the nanometer to micrometer length scale to control size, shape, and composition of designed protein assemblies. In the first approach, the structural and mechanical properties of the assembly will be defined by the protein components, while the nucleic acid component serves merely to define the dimensions of the assembly and to introduce addressability to an otherwise symmetric, repetitive assembly. All components, including the nucleic acid template, can be genetically encoded, potentially enabling assembly of entire nanoparticles inside living cells. The second approach uses more complex nucleic acid templates, such as DNA or RNA nanostructures, to control size, shape, and addressability of two- or three-dimensional protein assemblies. The shape of the final protein assembly reflects the shape of the templating nucleic acid nanostructure, and the protein assembly can be viewed as a coating that adds rigidity, stability, and, crucially, biological functionality to the template nanostructure. Both approaches one and two are amenable to library-scale screening by coupling size and shape of the particles as well as patterning of functional domains (“phenotype”) to the sequence of the nucleic acid template (“genotype”). In a third approach, the nucleic acid is not incorporated into the final assembly, but merely serves as a “mold” to define size and composition of a protein assembly. A single DNA origami mold could thus “catalyze” the assembly of many nanoparticles, circumventing potential scalability bottlenecks from approach two. These assemblies use the synergy between DNA nanotechnology and protein design to achieve properties that would not be accessible to either technology alone.

Keywords: dna nanotechnology,dna origami,protein design,molecular design,bionanotechnology,dna binding proteins
Hypothalamic cell changes during menopause: the neuroendocrine origin of its metabolic alterations (HypoPause)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1498325.0
EU funding (EUR): 1498325.0
Participants: 1
Project status: SIGNED

Women health is heavily impacted by menopause, and specifically, metabolic alterations increase their prevalence compared to the pre-menopause stage. Among them, body weight increase associated with abdominal adiposity, augmented risk of metabolic syndrome accompanied with dyslipidemia, worsening of insulin resistance coupled to type 2 diabetes and reduced bone density which favors osteoporosis are commonly associated with this women’s period of life. The hypothalamus is a key brain area controlling several homeostatic systems such as energy balance, glucose homeostasis and bone metabolism. Ovarian hormones act on the hypothalamus to regulate female physiology but after menopause their production stops and both estradiol and progesterone are reduced to castrate levels. Previous data pointed that this lack of hormones affects hypothalamic function. However, whether menopause causes an alteration in the hypothalamic mechanisms controlling systemic metabolism and whether this potential impairment plays a role in the metabolic alterations associated with it, is currently unexplored. The global aim of HypoPause is to study the molecular and cell-specific changes occurring in the hypothalamus during menopause and understand their role in the pathophysiological mechanisms driving the metabolic alterations. To address this, a research plan will be implemented based on (i) multi-omics profiling and circuit plasticity assessment of the hypothalamus in preclinical models of menopause, ii) in vivo metabolic phenotyping and cell-specific manipulation of hypothalamic circuits in conditions mimicking menopause in rodents and iii) functional genome editing of molecular mechanisms in vivo and target-validation using human samples. HypoPause will provide the first molecular and cellular picture of the hypothalamic changes induced by menopause, and will represent groundbreaking research on the pathophysiological mechanisms of its metabolic associated comorbidities.

Keywords: neuroendocrinology,menopause,metabolism,hypothalamus,energy balance,glucose homeostasis,bone,estradiol,progesterone
STEPPING UP SCIENTIFIC EXCELLENCE AND INNOVATION CAPACITY FOR CLIMATE-RESILIENT CROP IMPROVEMENT AND PRODUCTION (CROPINNO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Germany,Italy,Spain
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1477250.0
EU funding (EUR): 1477250.0
Participants: 5
Project status: SIGNED

The CROPINNO establishes collaboration network between Institut za ratarstvo i povrtarstvo, Institut od nacionalnog značaja za Republiku Srbiju (IFVCNS), Novi Sad, Serbia and internationally-recognized research institutions from Spain (CSIC-IAS, Cordoba), Italy (UNIPD, Padova), and Germany (FZJ, Juelich and UROS, Rostock). IFVCNS is the National Institute of the Republic of Serbia and world-wide recognized institution in plant breeding. However, it still lacks in technology and innovation capacity in multi-omics and modern phenotyping, as well as in international visibility and project management and administration skills. The main objective of CROPINNO project is to step up and stimulate scientific excellence and innovation capacity of IFVCNS in the field of climate-smart crop improvement and production and enhance its ability to respond and create innovative solutions for the challenges that agriculture faces - climate changes and need to feed the increasing population. The other CROPINNO objectives are strengthening of the research management and administration skills of the IFVCNS and creating the conditions for positioning of IFVCNS as a regional hub of R&I in the area of agriculture and creation of Climate Crops Centre. These objectives will be achieved through a set of training, networking and dissemination activities, including short-term scientific missions, workshops, international summer schools, national and international conferences, as well as Field days. The expected impacts of CROPPINO include improved excellence capacity, enhanced strategic networking activities, raised reputation, research profile and attractiveness of IFVCNS and the research profile of its staff, strengthened research management capacities and administrative skills of IFVCNS staff, as well as improved creativity supported by the development of new research activities and collaborations and increased mobility of qualified scientists.

Keywords: crop improvement climate change multi omics phenotyping innovation capacity
PeptInsure: Using Peptides to ensure, assure and Insure protein authenticity and quality (PeptInsure)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Food fraud and mislabeling undermine public trust in the food industry and regulatory bodies. The scale of these issues is heightened by the so-called Protein Gap. PeptInsure offers a new solution to authentication of protein in the food and feed industries by leveraging the strengths of ZooMS for peptide mass fingerprinting (PMF) and the novel LAP-MALDI technology, enhancing the specificity, affordability, and efficacy of protein analysis. This unique combination, alongside advanced software tools, enables PeptInsure to transcend the limitations of existing methods, such as specificity issues, costliness, and the impact of processing on detectability, positioning it as a pioneering solution capable of redefining protein analysis standards. These factors combine to position PeptInsure as a pioneering approach that could redefine standards for protein analysis in food and feed, with implications for safety, quality, and consumer trust. While existing methods each contribute valuable tools for protein analysis in food and feed, they are often hampered by limitations related to specificity, cost, and the impact of processing on detectability. PeptInsure's innovative integration of technologies aims to overcome these challenges, offering a comprehensive, reliable, and cost-effective solution for protein authentication and quality assurance in the food industry. If successful, PeptInsure stands to offer groundbreaking innovations in the field of protein analysis, with far-reaching implications for food safety, quality assurance, and market integrity. However, the project's high-risk elements, including the integration of complex technologies, adaptation to diverse matrices, and the need for advanced data analysis approaches, pose significant challenges. Overcoming these challenges will require innovative solutions, interdisciplinary collaboration, and a commitment to research and development, underscoring the high-risk/high-gain nature of the PeptInsure project.
Fediversity (Fediversity)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Countries involved: France,Denmark,Netherlands
Call: Pilots for the Next Generation Internet (IA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 3157500.0
EU funding (EUR): 3000000.0
Participants: 4
Project status: SIGNED

Open internet discourse is part of the future of open collaboration and open discussion, forming a federated safe space for what used to be called social networking. The Fediverse, funded by the NGI program as an implementation of such a federated space, is already taking shape and approaching ten million users. It has special safeguards for marginalized and oppressed groups in our global society. This NGI technology is mature enough to be joined by older institutions and organizations, many tech-savvy media outlets and public institutions have already joined [^adoption]. But for wider adoption the Fediverse needs to be supported by dedicated and knowledgeable support organisations, for which this project will lay the groundwork in the form of reproducible deployment configurations, how-to documents, cookbooks, playbooks and descriptions of success stories. Not only will we create a complete script for support organisations that want to _host_ Fediverse services and other open discussion tools on how to deploy them on their infrastructure, we will also onboard several public organisations that want to _use_ these services to show-case, and to gain and document experience on do's and don'ts. After all, public communication infrastructure, even though very practical, isn't easy to do and this project is accordingly about creating a simple to use, very practical and safe environment to communicate, assembling various powerful components that NGI and others have built into unified end-to-end services. This is where we can make a difference, especially in contrast to existing centralized solutions owned by Big Tech.

Keywords: fediverse federation social networking
Expanding the European EHRxF to share and effectively use health data within the EHDS (xShare)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Denmark,Belgium,Austria,Netherlands,Portugal,Germany,Greece,Ireland,Spain,Italy,Estonia,Cyprus,France,United Kingdom,Norway
Call: Expanding the European Electronic Health Record exchange Format to improve interoperability within the European Health Data Space (HORIZON-HLTH-2023-IND-06, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 7803632.5
EU funding (EUR): 7803632.5
Participants: 40
Project status: SIGNED

xShare envisions everyone sharing their health data in EEHRxF with a click-of-a-button. The xShare button to be featured across health portals and patient apps and allow people to exercise their data portability rights under GDPR. Hence, the European EHRxF will be the driver for research and innovation in EHDS. xShare will establish the European EHRxF Standards and Policy Hub, the “Hub” partnership of six standards developing organizations (CEN/TC251, HL7 Europe, IHE Europe, SNOMED, CDISC, IEEE) market actors (DIGITAL Europe, MedTech-Europe and EUCROF), supported by competence centers, nationals and regional authorities and European SMEs. xShare will develop: 1) Harmonized common specifications, create and maintain xBundles i.e., collection of common data specifications including FHIR implementation guides, tools and data sets, and educational support for key EHRxF health information domains as noted in the EHDS draft regulation Annex 1. 2) A set of common elements across EHRxF health information domains applicable across EHDS-1 (JA-9), public/population health (EHDS-2), and clinical research. 3) Extended harmonized IPS specification to include care plans and making it fit for the purpose of clinical research use cases i.e. clinical trial eligibility, real world data, patient reported outcomes, and returning clinical research data to patients. 4) xShare feature the xShare Button in 8 adoption settings in Hospital network (Italy), National portal (Greece, Ireland, Cyprus), regional network with emphasis in medical tourism and the connection of the public to the private sector (Catalunya and Madeira), entry of digital health applications to the myHealthSpace ecosystem in France. Care plans will be demonstrated in Denmark. xShare investigate the feasibility and value of the EU xShare Industry label as a vehicle towards implementing the draft EHDS regulation. Lastly open calls at the last year of the project aim to onboard with EHRxF almost 100 settings across Europe.

Keywords: expansion of european ehrxf european health data space trusted data sharing interoperability health data portability standardisation primary and secondary use of data harmonisation of formats