Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ILLUMINATING ROUTES TO 3D ORGANOBORON MOLECULES (LUMIBOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1457385.0
EU funding (EUR): 1457385.0
Participants: 1
Project status: SIGNED

With a steadily growing, aging population, there is significant strain on the pharmaceutical sector to produce state of the art therapeutics for societal needs whilst respecting the finite resources provided by the environment. Prominent advances in drug design are reliant on chemical synthesis platforms allowing the efficient exploration of chemical space to discover next generation functional molecules. As a result, innovation is currently limited by the practical implementation of enabling methods, which often becomes the rate limiting factor in cutting-edge research: this is more pronounced when translating academic research to industrial settings. The current renaissance of organic photochemistry and light-driven processes in a broader sense provide an opportunity to reconcile the growing demand for new functional molecules with consideration of sustainability and atom economy. Inspired by the importance of organoboron motifs in medicinal chemistry, this EU action “LUMIBOR” will harness the untapped potential of boron hybridization and boron ligand design to unlock new excited state reactivity paradigms and thereby facilitate the discovery of new methods to access achiral and chiral 3D organoboron scaffolds. LUMIBOR will create a structural platform to utilize boron hybridization in the development of next generation light-enabled ACTIVATION methods. Understanding the correlation between hybridization and parameters such as excited state energy and adjacent bond dissociation energy will allow access to synthetically versatile, high-energy intermediates such as α-boryl radicals and the triplet excited state. Strategic control over boron hybridization will also be utilized to regulate REACTIVITY, by influencing radical philicty, spin density, and excited state lifetimes among other parameters. Collectively, LUMIBOR will create expansive guidelines to expand the synthesis arsenal by developing novel platforms to construct desirable 3D organoboron molecules.

Keywords: boron,photochemistry,medicinal chemistry,
Polymer-based Stealth Coating of Hemocompatible and Absorbable Stents (StealthStent)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark,Germany
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 3565255.71
EU funding (EUR): 2495679.0
Participants: 2
Project status: SIGNED

Congenital Heart Diseases (CHD) are the most common type of birth defect, affecting more than 1,400,000 newborns annually. About 40% of these children need a stent treatment before they are fully grown, however there is no specific treatment for pediatric patients. The current standard of care is the off-label use of permanent stents designed for adults which is heavily affected by Foreign Body Reaction (FBR), stent migration and breakage. This leads to a high risk of patient mismatch, severe adverse events, high rate of re-interventions and high treatment costs. The StealthStent consortium is developing the world’s first stent explicitly designed for treating CHD in children. The StealthStent is made of an absorbable material that dissolves in 6 months allowing vessel growth and it is coated with a zwitterionic polymer-based coating that prevents FBR. The potential benefits of StealthStent resorbable stent are significant for adults thanks to its enhanced performance against FBR and decreased need for re-interventions. During this project, we will optimise the stent design to improve its radial force for adjusting it to the several types of CHD. We will optimise a zwitterionic polymer which was developed in the former FET-Open Project STARDUST and validated to address FBR but not yet absorbable. The polymer will be applied to an absorbable stent, which for the first time, could solve the unmet growth problem of current stents for children and significantly improve the standard of care for adults. Based on results obtained so far and on the planned development, we expect the StealthStent will reduce the risk of FBR, breakage, and migration to ≤5%. The coated stent will be tested in vitro and in vivo, resulting in a TRL 5 by the end of the project. Simultaneously, we will further develop and constantly update a business plan to outline the roadmap until market entry and we will further develop our go-to-market strategy.

Keywords: zwitterionic polymer,cardiac stent,biocompatibility,biodegradability
Identifying molecular features of potent antibody and memory B-cell responses associated with RTS,S malaria vaccine efficacy (HUMALCOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Malaria is the most important parasitic disease being a leading cause of death among young children, particularly in sub-Saharan Africa. In the context of the World Health Organization (WHO) strategic goals for a world free of malaria, there is a strong need of highly efficacious vaccines. Despite the RTS,S/AS01 (RTS) vaccine candidate was recently approved for use in African children, it demonstrated a modest efficacy during phase 3 clinical trials. Hence, a better understanding of the determinants of long-lasting immunity induced by the RTS,S is required to support improved next-generation vaccines aiming to provide the maximum coverage to target populations. In this regard, previous serological analyses demonstrated that high antibody levels and avidity are associated with vaccine efficacy in African children recipients. However, the molecular mechanisms and the cellular immune phenotypes supporting such potent antibody responses have not been fully deciphered. To fill these knowledge gaps, we propose to develop an in-depth humoral immunoprofiling within the large multicenter RTS,S phase 3 clinical trial, using already collected samples from African children participants. By generating a collection of antigen-specific monoclonal antibodies, I will investigate the molecular features of the RTS,S-induced memory B-cell response and the most relevant target epitopes. In parallel, I will identify the lymphocyte populations mobilized upon highly responding serological profiles, to subsequently develop a multivariable analysis integrating clinical-epidemiological, serological and cellular datasets to elucidate hallmarks of potent antibody responses and vaccine efficacy.

Keywords: humoral immunology memory b cells monoclonal antibodies systems immunology malaria
Achieving Ecological Resilient Dynamism for the European food system through consumer-driven policies, socio-ecological challenges, biodiversity, data-driven policy, sustainable futures (ECO-READY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Czechia,Germany,Belgium,Greece,Italy,Sweden,Netherlands,Cyprus,United Kingdom,Türkiye,Serbia
Call: Fostering the resilience of agricultural production: from observation of changes to the development of resilience strategies (HORIZON-CL6-2022-CLIMATE-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 13628428.75
EU funding (EUR): 13628428.5
Participants: 18
Project status: SIGNED

The ECO-READY project will develop a real-time surveillance system, an Observatory offered as an e-platform and as a mobile application. This will function as the necessary singular source of information, provide real-time assessments for the food system, and update forecasts frequently and consistently. The Observatory will be available to society, policymakers, the scientific community, and the agri-food industry, and integrated with a network of 10 Living Labs, supported through the third party funding process, covering all bioclimatic regions in Europe, forming the ECO-READY project knowledge infrastructure. ECO-READY will produce knowledge-based resilience strategies, and develop tools that will be embedded on the Observatory. The underlining principle behind the ECO-READY approach is, resilient dynamism, or tackling immediate problems and long-term challenges at the same time. The Living Labs network will facilitate ‘concept to action’ through the co-creation of scenarios addressing their regional needs, the development of policy recommendations, contingency plans, and resilience strategies, and embed them on the Observatory. Furthermore, ECO-READY will develop an early warning system and decision support tools using innovative Artificial Intelligence based on holistic prediction models and Life Cycle Assessment results. ECO-READY will ensure that European farmers and society’s interests be reflected in future policy-making and monitoring, through early-stage active engagement incorporating bottom-up recommendations, facilitated by the increased usership of the digital tools developed, and resulting in increased awareness for climate-adaptive and mitigating agri-food products. Furthermore, the Observatory smart application will include tools that will empower the citizens to actively engage in policy making, and interact directly with the scientific community, farmers, and industry and policy makers, thus driving change in consumption habits.

Keywords: food security,farm to fork,early warning,decision support tools,socio ecological challenges,biodiversity,data driven policy,sustainable future,observatory
Development of carbohydrate based anticancer agents (CarboMed)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

CarboMed will assess the commercial viability of targeting cancer cell glycosylation as a next-generation therapeutic strategy to treat cancer in the clinic. Carbohydrates (glycans) coat the cell of every organism. The glycosylation pattern of cancer cells is, however, very different from that of healthy cells and is associated with aggressive and invasive forms of cancers. By combining our knowledge on carbohydrate chemistry and cancer immunology we targeted the cancer-cell protecting carbohydrate coat, hampering the cancer's ability to grow and metastasize. In this project, we aim to deliver a technical and commercial proof-of-concept for targeting the glycosylation of cancer cells to ultimately enable clinical studies
A Middle Way? Probing Sufficiency through Meat and Milk in China (MidWay)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1431630.0
EU funding (EUR): 1431630.0
Participants: 1
Project status: SIGNED

About one-fifth of the world's greenhouse gas emissions come from agriculture. Much of this relates to livestock used for animal-based foods. Rather than arguing for increased efficiency, MidWay probes the concept of sufficiency to explore its potential for reducing human impacts on Earth's biosphere while preserving overall welfare, i.e., its potential for defining a 'middle way' between 'too little' and 'too much'. To do this, MidWay studies the cases of meat and milk in China. While meat was always a high-status product, milk was historically considered a 'barbarian' food, and most Chinese were intolerant to it. Both products were scarcely consumed in Chinese history but have boomed in popularity over the past 40 years. While often thought about as a change of consumer preferences, it has taken a concerted effort by the Chinese government and domestic and international actors to make both products integral to Chinese food practices. Seeing China as a strategic research site to ask questions about the supply and demand of animal foods, the MidWay project hypothesises that what has made meat and milk integral to Chinese food practices might also be 'otherwise', i.e., opening up a possibility for a future disembedding of meat and milk from food practices. Thus, using a constructivist inspired lens, MidWay makes use of practice theory and 'systems of provision' to study the normalisation of animal foods in China, particularly since 1978, with China's opening up. The ultimate objective is to probe the concept of sufficiency as a useful organising principle to achieve reduced consumption - highlighted through the sub-objectives of understanding how meat and milk have been rendered desirable in China. Perspectives that show how food is connected to social, technical and cultural variables, and the system that provides food, are lacking internationally and could lead to changes through facilitating a multifaceted policy response.

Keywords: practice theory systems of provision foodways and food chains sufficiency demand
Doctorate Career Development and Mobility Studentships in Medical Device Research and Advancements: Enhancing the CÚRAM Industry-Academia Training Initiative (MedDevDoc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland,Spain,United States
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2023-12-01
End date: 2029-11-30
Duration (months): 72.0
Total project cost (EUR): 3360000.0
EU funding (EUR): 3360000.0
Participants: 10
Project status: SIGNED

A major limitation for the introduction of novel medical devices to the market is the gap between research outputs and industry interactions. Innovations arising from academic institutions are rarely well aligned with commercial requirements (e.g. regulatory, pricing, patient needs). This impedes the efficient development of medical devices, which increases the time for innovations to reach patients. The Medical Device Doctoral programme, MedDevDoc, will address this gap by providing world-class research and training to 25 doctoral students. These students will be highly employable cross-border and -sector, capable of driving innovation in the European MedTech ecosystem. MedDevDoc is aligned with the EU principles for Innovative Doctoral Training, as well as the EU Charter and Code, and the Salzburg Recommendations. Novel aspects of MedDevDoc include a personal career development plan, which gives students a strong sense of ownership of their own career; a focus on sustainable laboratory practice by exploiting NUIG’s position as the first in Europe to be awarded a Green Lab certification; and extensive training in public engagement through the internationally recognised Education and Public Engagement programme, which is supported by experts such as teachers, filmmakers, and artists. The University of Galway (NUIG) is uniquely positioned to deliver MedDevDoc due to its position as headquarters of the CÚRAM network. CÚRAM is the national Science Foundation Ireland Research Centre for Medical Devices, created by the Irish government to close the gap between research and industry in the medical device field. NUIG will work together with the 8 other high-quality academic centres within the CÚRAM network, as well as 14 industry partners, to implement MedDevDoc. Upon completion of the 60-month programme, the next generation of entrepreneurial, multidisciplinary, and creative innovators in the field of medical devices will be ready.

Keywords: medical device,training,career development,sustainable lab practices
Colourful predictions? Unraveling the resolution and neural mechanisms of colour expectation (COLOUR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-03-31
Duration (months): 30.0
Total project cost (EUR): 215165.76
EU funding (EUR): 215165.76
Participants: 1
Project status: SIGNED

Whether doing sports or driving through city traffic, our visual system constantly builds expectations to predict and quickly react to upcoming events. However, despite the great importance of expectations, their form and neural implementation remain a mystery. It is completely unknown whether expectations encode a clear picture of the anticipated visual input or just a rough sketch. This gap in knowledge is vital, since only things encoded in our expectations are expected to enter conscious awareness faster. Given the high value of colour signals to guide attention in everyday life (e.g., traffic signs), this project asks where and when in the brain colour expectations are formed and if they are in full colour or just comprised of few basic hues. To track cortical colour expectations with high spatiotemporal precision, electro- and magnetoencephalography will be combined with anatomical brain scans and cutting-edge computational decoding in a new, integrative approach. First, a decoding model will be built that reconstructs colour from brain responses. Applying this new model to brain activity of participants anticipating colours will elucidate when and where in the brain colour expectations are formed. Combined behavioural and electromagnetic measures will then determine the influence of these expectations on our perception. Finally, combining the decoding model with colour similarity levels and individual colour categorizations will clarify the resolution of colour expectations. This project will be the first to unravel the neural mechanism, influence and limits of colour expectations. Together with the decoding model as future tool, this will open new perspectives on predictive processing, perception and imagery, but will also have widespread societal implications: designing of better recognizable colour traffic signals, improving colouring schemes in school books to more effectively guide attention, and even for decoding brain responses of locked-in patients.

Keywords: cognitive neuroscience,visual cortex,expectations,vision,eeg,meg,attention,perception
New Molecular and Cell-based Approaches to assess Food Astringency and Bitterness (BeTASTy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1499791.0
EU funding (EUR): 1499791.0
Participants: 1
Project status: SIGNED

Taste properties are vital to humans: they impact human survival, nutrition, health and well-being. The problem of unpleasant taste properties, namely bitter- or astringent-tasting compounds is emerging in many diverse research fields. Beyond the obvious interest in food science, nutrition, and in the improvement/selection of crops, also human taste disorders and drug discovery domains could also benefit from research on astringency and bitterness. Crossing the boundaries among different fields, BeTASTy goes beyond the current state-of-the-art of food-oriented researches to respond to the prominent challenges on astringency and bitterness. This proposal will provide an in-depth mechanistic and functional understanding into the MAIN PHYSICAL-CHEMICAL EVENTS triggering the physiological and neural perception of astringency by an innovative approach considering the main oral key pieces namely salivary proteins, epithelia and emphasizing the role of mechanoreceptors on that sensation. BeTASTy will also unveil how, for some compounds, astringency and bitterness CAN GO TOGETHER by an innovative all-in-one model. Additionally, the individual features that account for sensory differences will be deepened by a pioneering approach based on human organoids and electroencephalography. The final goal, will be the creation of cutting-edge CELL-FREE BIOSENSORS based on the identified orally active mechano- and bitter taste receptors to assess astringency and bitterness respectively, and by overcoming the main drawbacks of the existing (cell-based) ones. Endowed with a truly differentiated and disruptive character, this groundbreaking project will engage food chemistry, biochemistry, neuroscience, sensory analysis and biotechnology fields of research to outdo the state-of-the-art. Only an ambitious and multidisciplinary proposal will yield scientific breakthroughs on the BIOCHEMICAL-NEURAL-PERCEPTUAL TRIAD EVENTS of these taste properties which will eventually enable to tailor them

Keywords: mechanoreceptors,organoids,inter individuality,cell free biosensors