Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Thermally Integrated Smart Photonics Systems (TIPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Germany,Ireland,Ireland,France,France,France,France,Netherlands
Call: Smart System Integration (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 5230041.25
EU funding (EUR): 5230041.0
Participants: 14
Project status: CLOSED

The objective of this proposal is to develop and demonstrate a scalable, thermally-enabled 3D integrated optoelectronic platform that can meet the explosion in data traffic growth within ICT. The Thermally Integrated Smart Photonics Systems (TIPS) program will heterogeneously integrate micro-thermoelectric coolers (μTEC) and micro-fluidics (μFluidics) with optoelectronic devices (lasers, modulators, etc.) in order to precisely control device temperature and thus device wavelength compared to commercially available discrete technology. Data traffic is projected to increase sharply (40-80× by 2020) and this is driving an increase in network complexity and the requirement for scalable optoelectronic integration. A major bottleneck to this large scale integration is thermal management. Active photonic devices generate extremely high heat flux levels (~1 kW/cm2) that must be efficiently removed to maintain performance and reliability; furthermore, active photonic devices must be controlled at temperature precision better than ±0.1°C. Today’s thermal technology is at the limit and cannot scale with growth in the network. As a comparison, electronics produce lower heat flux levels (~100 W/cm2) and have a less restrictive temperature requirement of ≤ 85±2°C. Integration of thermal management onto optoelectronic devices has not been addressed to date in academic or industrial investigations and therefore presents a significant knowledge gap that must be filled to enable impact and ensure the EU is at the forefront of optoelectronic technology. While the end goal is driven by telecom or datacom industrial requirements there are many scientific knowledge gaps that will be filled by the TIPS consortium. The application space for a thermally-integrated smart optoelectronic solution is large and spans multiple communication length scales from long reach to inter/ intrachip communications as well as other applications like sensors that seek to leverage silicon photonics platforms

Keywords: lasers,microfluidics,thermoelectric coolers,thermal management,thermal integration
Smart mitigation of flow-induced acoustic radiation and transmission for reduced aircraft, surface transport, workplaces and wind energy noise (SmartAnswer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Switzerland,Belgium,Greece,Sweden,Sweden,Poland,Belgium,France,France,France,Netherlands,Netherlands,United Kingdom,Denmark,Canada
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 3842110.32
EU funding (EUR): 3842110.32
Participants: 23
Project status: CLOSED

A step change in our noise mitigation strategies is required in order to meet the environmental targets set for a number of sectors of activity affecting people through noise exposure. Besides being a hindrance to our daily life and subject to regulations, noise emission is also a competitive issue in today’s global market. To address these issues, new technologies have been emerging recently, based on radically new concepts for flow and acoustic control, such as micro-electro-mechanical devices (MEMs), meta-materials, porous treatment of airframe surfaces, airfoil leading-edge or trailing-edge serrations, micro-jets, plasma actuation, … Some of these new ideas appear nowadays promising, but it now appears to this consortium that the development and maturation of novel noise reduction technologies is hindered by three main factors. The first factor is an insufficient understanding of the physical mechanisms responsible for the alteration of the flow or acoustic fields. In absence of a phenomenological understanding, modelling and optimization can hardly be successful. Secondly, tight constraints (safety, robustness, weight, maintainability, etc.) are imposed to any novel noise mitigation strategy trying to make its way to the full-scale industrial application. Thirdly, there is an insufficient knowledge about the possibilities that are nowadays offered by new materials and new manufacturing processes. With this project, we intend to setup a research and training platform, focused on innovative flow and noise control approaches, addressing the above shortcomings. It has the following objectives: i) fostering a training-through-research network of young researchers, who will investigate promising emerging technologies and will be trained with the inter-disciplinary skills required in an innovation process, and ii) bringing in a coordinated research environment industrial stakeholders from the aeronautical, automotive, wind turbine and cooling/ventilation sectors.

Keywords: aero acoustics,vibro acoustics,structural dynamics,computational fluid dynamics,aircraft noise,heating ventilation and air conditioning systems,automotive noise,wind energy
DC-based immunotherapy to treat Malignant Mesothelioma (H2020MM04)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Belgium,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 5782965.0
EU funding (EUR): 5782965.0
Participants: 9
Project status: CLOSED

Asbestos is one of the major occupational carcinogens. The European Union has an extensive history of protecting workers and consumers against asbestos and even adopted a resolution 2012/2065(INI) ‘on asbestos related occupational health threats and prospects for abolishing all existing asbestos’ last year. Although asbestos is banned, it is still massively present in the built environment. Millions of workers & consumers in the EU were, and still are, for many years exposed to asbestos fibres, despite all measures. Inhalation of even very low quantities of asbestos fibres tremendously increases the risk of developing Malignant Mesothelioma (MM). The IARC reported 8.100 MM deaths in 2010 in the EU. Despite all EU actions, MM incidence is still increasing. MM is a highly fatal disease with a poor median survival time from first signs of illness to death around 12 months despite aggressive treatments. To date there is no curative therapy for MM. MM is considered as an extremely therapy-resistant disease. Chemotherapy consisting of a combination of pemetrexed and cisplatin is considered standard of care with a median survival increase of 3 months (9-12 months). The department of pulmonary diseases of the Erasmus MC, Rotterdam, The Netherlands, in collaboration with international partners, have developed a promising personalised immunotherapy for MM with very limited adverse effects. The first clinical results show a considerably prolonged average survival with limited adverse events (24 months, twice as long). The EMA and the FDA granted this therapy Orphan Designation: autologous dendritic cells pulsed with allogeneic tumour cell lysate for the treatment of malignant mesothelioma (EU: 16 January 2014 - EU/3/13/1229; FDA – US: 06 May 2014). The objective for the project is to deliver the scientific & registration package for market approval by the EMA of a novel immuno therapeutic approach to treat MM. This includes the execution of a phase II/III clinical trial.

Keywords: immunotherapy,malignant mesothelioma,dendritic cells
Digital readout of protein detection via super rolling circle amplification of DNA tags (DigiRead)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 149375.0
EU funding (EUR): 149375.0
Participants: 1
Project status: CLOSED

This project will serve to evaluate market opportunities of a newly invented technology for digital detection of reporter DNA strands in protein analysis. The purpose of my ongoing ERC project ProteinSeq is to develop technology and reagents for parallel, sensitive and specific targeted protein analyses in plasma samples, lysates, etc. An important limiting factor for the broader adoption of our technology is the cost and throughput of next generation sequencing and realtime PCR to read out the identities and levels of reporter DNA strands that reflect the amounts of proteins in a sample. In the course of the ERC project we have invented and patented a technique to greatly enhance each of the reporter strands to prominent DNA objects that can be easily detected, identified and counted by fluorescence microscopy with automated image analysis or through flow cytometry. We refer to this highly specific technique as super rolling circle amplification or sRCA, and it involves two generations of RCA and combinatorial fluorescence detection of the large products, each composed of hundreds of thousand repeats of specific tag DNA sequences. In the proposed PoC project we will position our new technology against other readout techniques such as next gen sequencing, realtime PCR and microarrays by identifying Needs, Approach, Benefits, Competition for sRCA. Potential end users will be contacted to establish customer requirements, and we will evaluate freedom to operate and the extent of monopoly for our invention. We will also specifically investigate means to distinguish many sRCA products by combinatorial labeling schemes.

Keywords: digital detection,biomarker,plasma proteomics,dna tags,rolling circle amplification,specificity,sensitivity,fluorescence detection
Development of composite structures having negative stiffness inclusions and exceptional damping properties (NS-COMP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The EU is a world leader in the development and manufacturing of structural products for the transport industry, with the aeronautical sector alone providing more than 500,000 jobs, generating a turnover of close to €140 billion in 2013 . Noise is a serious form of environmental pollution affecting the lives of hundreds of millions of citizens worldwide and having multiple socio-economic consequences. Moreover, intense vibration can endanger the structural integrity and performance of equipment and hardware. Modern industrial structures are made of composite materials due to their well-known benefits. Despite their superior structural characteristics, composite structures exhibit poor dynamic and acoustic isolation levels compared to conventional metallic ones. In order to keep noise and vibration levels at acceptable limits, structural manufacturers are nowadays obliged to extensively employ constrained-layer damping treatments that are expensive in terms of additional mass and space usage. NS-COMP will bring together an ER being expert in ‘wave propagation in phononic crystals and acoustic mematerials’ and a host institution carrying leading academic know-how in ‘design, optimization and manufacturing of multifunctional composites’. The Fellowship aims at developing novel structures having exceptional damping properties combined with the outstanding structural performance of a layered composite at minimum extra mass, volume and cost. This will be attained through the inclusion of internal purely mechanical Negative Stiffness (NS) elements in the core of the structure. According to conservative preliminary simulations, a successful completion of NS-COMP will deliver structures that have a damping ratio at least 300% superior (for the same stiffness/mass fraction) to that of the structures currently employed in the transport industry. The secondment of the ER to AIRBUS will ensure the applicability of this new family of structures to real-world industrial scenarios.

Keywords: structural dynamics,wave propagation,composite structures,negative stiffness,damping
MEMory processing in the human ENTOrhinal cortex (MEMENTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Deeply embedded in the medial temporal lobe (MTL) memory system, the entorhinal cortex (EC) is a small yet potentially key region for intact memory. While a series of recent ground-breaking findings in rodents point towards a pivotal role of EC in spatial navigation, thought of as an evolutionary precursor to memory, little is known about its precise contribution to episodic memory in humans. Building on preliminary evidence that EC subregions may be specialised for different stimulus types and/or different memory processes, MEMENTO proposes a systematic investigation of memory function in the human EC. The action combines state-of-the-art high-resolution and ultra-high field functional magnetic resonance imaging (fMRI) with advanced analysis techniques to assess how these EC subregions support material-specific memory processing on four levels of resolution: the laminar level, the subregion level, the system level, and the behavioural level. MEMENTO is highly collaborative: it brings together expertise of the ER (high-resolution fMRI of entorhinal cortex subregions), the host supervisor (functional dynamics of the MTL, advanced fMRI analysis), and the partner organisation (ultra-high field fMRI). Given that the EC is one of the first structures affected in Alzheimer’s disease, the project results have great potential to stimulate important clinical implications. The ER will advance her research profile through highly transferable experience not only with cutting-edge methods, but also with managing and engaging in scientific and public communicative events. This will qualify her to lead her own research group upon returning.

Keywords: entorhinal cortex,medial temporal lobe,episodic memory,high resolution fmri,ultra high field fmri
Understanding gamma delta T cells in colon cancer metastasis (GDCOLCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cancer is the leading cause of death in the world. Immunotherapy is having a major impact in counteracting these cancer-related deaths, since the activity of anti-tumour immune cells can be enhanced to kill cancer. Unfortunately, immunotherapy does not work for every patient, so we must understand how other immune cells participate in cancer progression to design new immunotherapies that may benefit a greater number of patients. One particular type of immune cell, called gamma/delta T cells, was recently shown by my Host to promote breast cancer metastasis via IL-17, an important pro-tumour cytokine. However, the significance of gamma/delta T cells and IL-17 in other cancer metastasis settings remains unclear. In this proposal, I will address this point using a newly developed sophisticated colorectal cancer metastasis model. This novel mouse model shows 100 percent penetration of metastasis, of which 80 percent is to the liver, similar to human colorectal metastasis. Using this metastasis model, I will: 1. Clarify characteristics of gamma/delta T cells in colorectal cancer metastasis, 2. Assess if depletion of gamma/delta T cells by a neutralizing antibody as well as crossing the model with gamma/delta T cell-deficient mice would reduce the occurrence of metastasis, and 3. Examine the involvement of BTNL1, which is a specific activator for anti-tumorigenic IFN-producing gamma/delta T cells in the intestine. The role of BTNL1 in any cancer setting and the importance of IL-17-producing gamma/delta T cells in colon cancer metastasis is largely unexplored. Addressing our goal to understand the role of these gamma/delta T cells in colon cancer metastasis, I will newly acquire expertise and technical skills in both immunology and cancer biology as well as have experience in excellent collaboration with several laboratories. This proposal will identify additional targets for immunotherapy that may help patients with metastatic colon cancer.

Keywords: metastasis,gamma delta t cells,colon cancer
Probiotics for the Oncological Patients (ONCOTICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Czechia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of this project is to perform the technological/comercial and economical viability of the newly developped very gentle form of microbial lysis which preserves the biologically active molecules of probiotic bacteria that favorably affects the cells of the intestinal mucosa and the mucosal immune system. This newly designed probioticsmodify the integrity of the intestinal mucosa damaged as a result of oncological treatment, to suppress inflammatory changes in the mucous membrane and, at the same time, to contribute to stabilization by the treatment of the disrupted microbiome. The ONCOTICS introduces novel treatment of intestines infections which brings : - Unique probiotical lysates product improving the oncology patients life comfort - New approach for elemination of syndrom leaky gut in oncological patients - Very safe gut barrier regeneration compared with standard probiotics, which can cuase sepsis - New patented technology for production of probiotics lysates - Novel therapy opening new markets

Keywords: probiotics,dry lysis,oncological patients,diarrhea
5G NOvel Radio Multiservice adaptive network Architecture (5G NORMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Italy,Finland,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2017-12-31
Duration (months): 30.0
Total project cost (EUR): 7921868.75
EU funding (EUR): 7921868.75
Participants: 17
Project status: CLOSED

The key objective of 5G NORMA is to develop a conceptually novel, adaptive and future-proof 5G mobile network architecture. The architecture is enabling unprecedented levels of network customisability, ensuring stringent performance, security, cost and energy requirements to be met; as well as providing an API-driven architectural openness, fuelling economic growth through over-the-top innovation. With 5G NORMA, leading players in the mobile ecosystem aim to underpin Europe’s leadership position in 5G. Relevant to strands "Radio network architecture and technologies" and "Convergence beyond last mile", the 5G NORMA architecture will provide the necessary adaptability able to efficiently handle the diverse requirements and traffic demand fluctuations resulting from heterogeneous and changing service portfolios. Not following the ‘one system fits all services’ paradigm of current architectures, 5G NORMA will allow for adapting the mechanisms executed for a given service to the specific service requirements, resulting in a novel service- and context-dependent adaptation of network functions paradigm. The technical approach is based on the innovative concept of adaptive (de)composition and allocation of mobile network functions, which flexibly decomposes the mobile network functions and places the resulting functions in the most appropriate location. By doing so, access and core functions no longer (necessarily) reside in different locations, which is exploited to jointly optimize their operation when possible. The adaptability of the architecture is further strengthened by the innovative software-defined mobile network control and mobile multi-tenancy concepts, and underpinned by corroborating demonstrations. 5G NORMA will ensure economic sustainability of network operation and open opportunities for new players, while leveraging the efficiency of the architecture to do so in a cost- and energy- effective way.

Keywords: network architecture,radio access network,core network,techno economics,cloud,function allocation,multi service,multi tenancy,demo,adaptability,cost energy effective