Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Disruptive Treatment Control Software for Particle Therapy Centers (C-TCS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovenia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cancer is one of the leading causes of death nowadays; 1 in every 2 men and 1 in every 3 women will be diagnosed with cancer at some point of their lives. The number of cancer incidences is growing by 2.4% annually, which puts a financial burden on healthcare systems globally. Particle therapy – PT (proton/neutron/positive ion therapy) has been proven to be effective and a safer alternative to other types of external beam radiotherapy as the charged particle dose is delivered in a narrow range and there is minimal damage to surrounding tissue. In 2015, among all patients that were treated for cancer worldwide, 25% were treated using some sort of radiation. However, building PT centres is very costly (>100M €) which has been a crucial factor in the slow adoption of PT facilities. This is likely to change due to introduction to lower cost/compact systems, and, more importantly, growing clinical evidence regarding its efficacy. A critical part of a PT centre is its treatment control system (TCS), the software that synchronizes the operation of all the devices. Currently, PT centre equipment vendors each custom develop their own TCS, which works only with their own equipment, is of limited configurability, closed to adjustments and expensive. Cosylab is a Slovenian company specializing in the field of control systems for particle accelerators with 17 years of experience in the field. We are developing our TCS (C-TCS) as an off-the-shelf product, that is universally usable on all vendors´ (integrators or manufacturers´) equipment. Our solution is easily configurable, available without lead times, and costing 3-5x-less than custom development. Overall, the C-TCS provides better cancer treatment efficacy, lower production and maintenance cost of PT facility, higher throughput of patients (resulting in more people treated). In 5 years after completion of the project (2025) we expect to employ additional 20 people and achieve a ROI of 5.6.

Keywords: cancer,proton therapy,particle therapy,treatment control system,software
eXTEnded AtM for Door2Door travel (X-TEAM D2D)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Italy,Germany,Italy,Italy,Poland,Netherlands
Call: ATM Role in Intermodal Transport (H2020-SESAR-2019-2, 2019)
Start date: 2020-06-01
End date: 2022-09-30
Duration (months): 28.0
Total project cost (EUR): 997375.0
EU funding (EUR): 997375.0
Participants: 8
Project status: CLOSED

X-TEAM D2D project aims defining, developing and initially validating a Concept of Operations (ConOps) for the seamless integration of ATM and Air Transport into an overall intermodal network, including other available transportation means (surface, water), to enable the door-to-door connectivity, in up to 4 hours, between any location in Europe, in compliance with the target assigned by the ACARE SRIA FlightPath 2050 goals. The project is focused on the consideration of ConOps for ATM integration in intermodal transport network serving Urban and Extended Urban (up to Regional) mobility, taking into account the transportation and passengers service scenarios envisaged for the next decades, according to baseline (2025), intermediate (2035) and final (2050) time horizons. The target ConOps provided and initially validated by the X-TEAM D2D project will encompass both the transportation platforms integration concepts and the innovative seamless mobility as a service including ATM concepts. The developed ConOps will be preliminarily evaluated against already existing and specifically defined applicable KPAs and KPIs, implementing both qualitative and quantitative performances assessment approach. The X-TEAM D2D project will develop a simulation-based platform for validating the proposed concept. This platform will consider the most relevant elements of the transport in the future such as interfaces mode-mode, high-level network model, passenger-centric paradigm. The X-TEAM D2D proposed ConOps, therefore, will be validated with the simulation platform and a description of the semantic values of future KPIs and a diagnosis of the inefficiencies of the ConOps will be provided. The conceptual design of the platform will be replicable by formalizing the relationships of the Key elements by using formalisms like Coloured Petri Nets or UML. The identified hot areas of the different interfaces will be formalized by the use of Colored Petri nets or similar formalism.

Keywords: air traffic management,door to door,urban air mobility,conops,intermodal transport,passenger experience,optimization,air transport,surface transport,water transport,simulation
Frozen Fried Eggs: Industrial process for the manufacture of frozen fried eggs (FFEs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

IFOODS360 (Innovation Foods) is a food producing company created by seasoned entrepreneurs from different fields like AgriFood, HORECA channel, Marketing and Management. We brought our expertise to this company in order to implement our patented process for producing and distributing frozen fried eggs. Our company manufactures and markets frozen fried egg through its worldwide registered patent. It is a natural product without any additives or salt, and our industrial processing has obtained the certifications ISO 22000 and IFS. The process of elaboration and freezing guarantees better nutritional levels than domestic or catering processing. Innovation Foods responds to food industry market by means a frozen product, offering to the end customers a solution necessary and non-existent at present, with all sanitary guarantees. Egg is a natural food considered as one of the most complete in nutrients that exist and it provides the most affordable protein on the market. It is an environmentally sustainable product and its consumption does not generate religious, cultural, temporary or other conflicts. Challenge: There is an upward trend in the consumption of frozen food, prepared and / or precooked, based on healthy food, flexibility in shelf life, versatility of the product offered and saving time in the kitchen. Frozen foods have a longer expiration date, without altering their nutritional properties, eliminate the risk of bacteria generation along the supply chain and lower the final price in the market. Changes in the way of life and consumption habits have driven a 38% growth in the frozen food market in the last decade. At present, almost all European households have frozen foods in their usual diet and they represent 6% of their shopping basket. In catering and restaurants business sector, it ranks 5th in highest expenditure products, after meat, fish, charcuterie / cheese and bread (many of these also supplied as frozen product)

Keywords: food safety,protein food,healthy diet
HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY (HiFi Brilliancy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: SIGNED

The ultimate goal of this Fellowship, entitled “HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY” (HIFI BRILLIANCY) is to enhance the creative and innovative potential of an experienced researcher, helping him to diversify his individual competence through a research project focused on the development of novel tools for optomechanical imagine of biomaterials towards in vivo real-time endoscopy. This will be achieved putting forward the latest methods of stimulated Brillouin scattering enabling recording Brillouin Gain Spectra in biomaterials. The Fellow – Dr Andrei Fotiadi – will be trained in biophotonics, a fast-growing field of science, and medical application. The HiFi Brilliancy outputs will be relevant to the EU Information Science and Engineering sector by offering new cost-efficient technologies for real-time in vivo Brillouin Imaging. Given the huge and fast-growing market of medical diagnostic equipment, the project results have a good opportunity for successful commercialisation. The Fellow will use his present connections to optical equipment manufacturers in EU to develop commercialisation opportunities, and new connections will be established through this project. The project brings together an experienced research Fellow with a strong scientific and engineering background in Brillouin photonics and an internationally growing group of researchers at Opto-Electronics and Measurement Techniques (OPEM) unit (University of Oulu, Finland) with expertise in the area of developing laser-based photonic devices for biomedical imaging. The Fellow will be further supported by medical and industrial expert co-hosts who will help train the Fellow in key skills and support the translational research process. The translational part of the project will primarily be aimed at adapting results of scientific studies to actual conditions of clinical practice. It will permeate the whole project and will be a complex of scientific research and training of the Fellow.

Keywords: brillouin imaging,brillouin spectrometry,optomechanical diagnostic methods,mechanobiology,endoscopy,elastic and viscous tissue properties,brillouin dynamical gratings,biophotonics
Structural and Functional Studies of ATRX- Syndrome Protein (SFSASP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The eukaryotic genome is packaged into chromatin, which needs to be unpacked to provide necessary access by cellular factors for varied cellular functions. However, DNA can be rendered accessible by the action of energy-consuming chromatin remodelling proteins. One such protein is ATRX that harbours an N-terminal plant homeodomain (PHD) and a C-terminal helicase domain that confers ATPase activity and identifies ATRX as a member of the snf2 family member of chromatin remodellers. ATRX has been shown to localize in vivo with constitutive heterochromatin in pericentromeric regions as well as telomeres where it works in complex with DAXX for the deposition of the Histone3.3. Mutations in the ATRX gene give rise to ATR-X syndrome, a severe X-linked mental retardation syndrome often accompanied by alpha-thalassemia. Mounting evidence links ATRX mutations to cancer and to malignancies that depend on a telomerase-independent pathway of telomere maintenance called the ‘alternative lengthening of telomeres (ALT) pathway, linking ATRX to aging. Despite these advances however, there is lack of understanding of the molecular mechanism of ATRX and of its role within these pathologies. The proposed research aims to investigate the structural and functional properties of ATRX, and to define at a molecular level how it interacts with DAXX to remodel chromatin. We will use a combination of biophysical techniques like NMR, Isothermal Calorimetry and western blotting to characterize ATRX interaction with partner proteins. X-ray crystallography, Cryo-electron microscopy and Small angle X-ray scattering techniques will be used to elucidate the structure of ATRX complexes. We will also design assays to measure the enzymatic activity of the ATRX snf2 domain by itself and in presence of DNA and/or its interacting partners. These studies will provide insight into a potential new mechanism of chromatin remodelling and will help us elucidate the consequences of disease-related ATRX mutations.
Personalized oncolytic vaccines for cancer immunotherapy (PeptiCrad)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1975705.0
EU funding (EUR): 1975705.0
Participants: 1
Project status: CLOSED

This grant application proposes to develop a novel, customizable and personalized anti-cancer vaccine: peptide-coated conditionally replicating adenovirus (PeptiCrad). Anti-cancer vaccines represent a promising approach for cancer treatment because they elicit durable and specific immune response that destroys primary tumors and distant metastases. Oncolytic viruses (OVs) are of significant interest because in addition to cytolysis they stimulate anti-tumor immune responses, thereby functioning as anti-tumor vaccines. However, their efficacy among cancer patients has been modest. One reason for this shortcoming is that the immune responses generated by virus infection primarily target the virus rather than the tumor. In addition, tumors differ across patients. Specific and personalized approaches (rather than generic virus infection strategies) are required to optimize therapy. To this end we propose to develop a novel vaccine platform that combines the strengths of OVs with the specificity of vaccines. Our technology is called PeptiCrad. PeptiCrad is a virus “dressed as a tumor”. It directly kills cancer cells (i.e., oncolytic viruses) and expresses immunomodulatory molecules (i.e., cytokines or the immune checkpoint inhibitors anti-CTLA4 or anti-PDL1); most importantly, it diverts immunity toward the tumor (i.e., the capsid becomes covered with MHC-I-restricted tumor-specific peptides). The method that we have developed to cover the virus with tumor peptides is novel and exceeds current state-of-the-art. Importantly, it is fast and does not require genetic or chemical manipulation of the virus; this feature has a significant impact on the translational capability of the project. Our preliminary results show great potential but significant questions regarding the development and the personalization of PeptiCrad remain to be studied. In this grant I propose two lines of research, one focused on the development and the other one on the personalization of PeptiCrad.

Keywords: adenovirus,oncolytic vaccines,vaccines,immunotherapy
Networks of Practice in New Music Theatre (NePraMusT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-09-01
End date: 2025-03-01
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

From the 1960s to the 1980s, numerous younger European composers were drawn to theatrical projects that overturned the established conventions of the opera house. These projects were typically small in scale and experimented with new relationships between instrumental performance and staged action. This ‘New Music Theatre’ is today regarded as an important manifestation of the experimental spirit of the time, and remains widely influential upon present-day creative production. However, histories of the genre have been misleading in focusing almost exclusively upon the figure of the composer. Documentary evidence shows clearly that new music theatre typically emerged from collaborations between composers, writers, directors, and performers, who dynamically mediated practices and theories from different disciplines and backgrounds. For instance, singer Roy Hart inspired works by Stockhausen and Henze, Eugenio Barba’s and Berio’s contemporaneous views about voice were liminal, while Peter Brook’s dramaturgy was supported by the work of lesser known composers and practitioners. NePraMusT aims to retrace some of those interactions, voicing the role of numerous creative agents currently underrepresented in official accounts. Through gathering extensive documentary evidence from European archives and undertaking practice-led investigation of historical actor training and voice work, the action will establish how music and theatre converged in these projects, throwing light on the creative and aesthetic crosscurrents that have heavily shaped present-day creative practices. NePraMusT will contribute to enhance the ER’s skills and future employability prospects, opening new training opportunities both as an academic and an artist-researcher, furthering her ability to plan, organise, develop her dissemination and public outreach competencies, and reinforcing her professional networks of practitioners and researchers versed in theatre and music theatre studies.

Keywords: performance,networks,practice based research,music theatre,theatre,practice,actor training,vocality,music history,embodiment
Novel forms of magnetism in 2D transition metal dichalcogenides (MAGTMD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The ultimate goal of this project is to demonstrate that the enhanced electronic correlations in transition metal dichalcogenides (TMDs) lead to different expressions of magnetism in the two-dimensional (2D) limit. Beyond the prototypical case of a 2D magnet vanadium diselenide, many different TMDs materials, in their 2D limit, have the potential to host magnetic order, which often will coexist with other collective electronic states such as superconductivity. Here, the starting hypothesis stems from strong electron-electron interaction that are intrinsically present in TMD materials and further, in two dimensions, reduced screening results in markedly enhanced electron–electron interactions which usually favor the emergence of magnetic order. This project will focus on select TMD materials of particular interest for different reasons, such as magnetism in coexistence with superconductivity, emergence of a half-metal state, and magnetism generated by atomic vacancies. By using ultra-low temperature scanning tunneling microscopy and spectroscopy, this project will offer significant insights in the field of 2D magnetism by investigating the emergence of magnetic order in these strongly correlated TMD materials and its interplay with other electronic phases.

Keywords: magnetism,scanning tunneling microscopy,transition metal dichalcogenides,devices,molecular beam epitaxy,2d materials
G9 GREEN NIGHT (G9NIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Spain,Spain,Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-04-30
Duration (months): 12.0
Total project cost (EUR): 223615.0
EU funding (EUR): 155000.0
Participants: 8
Project status: CLOSED

The GREEN 9 NIGHT (G9NIGHT) will be our 2nd experience as a consortium in managing the European Researchers' Night in Spain. This consortium has been designed to increase the awareness and perception of research as a source of solutions to the huge challenges our society is facing. It is composed of a team of eight Spanish universities acting as main partners and coordinated by University of Oviedo, covering approximately 40% of Spanish territory. The initiatives will be organised in accordance with the main policy areas identified in the GREEN DEAL: Industry for a clean and circular economy, EU climate ambition for 2030 and 2050 Clean, affordable and secure energy Sustainable and Smart Mobility and fair, healthy and environmentally-friendly food system, among others. The G9NIGHT consists of two different major framework events and related initiatives, with pre-events motivated by the celebration of World Environment Day (5 June) and World Oceans Day (8 June) and the European Year of Rail 2021. The main event will hold 24 September 2021 in thirteen cities. During the project's lifetime, the consortium will launch a campaign "Do your bit to keep Europe green and be an ambassador for climate action" for promoting individual actions on climate change and sustainability. The events will be simultaneously celebrated across Spain with a common aim: bringing researchers closer to the general public and increasing awareness of research and innovation activities, creating an understanding of the impact of researchers, work on citizens, daily life, fostering interest in science among younger students, and encouraging those at university to embark on research careers. Gender equality will be guaranteed in activities, researchers and organization members. The European dimension will be emphasised by the active involvement of researchers with European funds and Marie Sklodowska-Curie fellows, in eight actives EU Corners. The project includes European collaboration.

Keywords: science researchers research education outreach europe gender equality green deal scicomm nightspain sustainability green deal