Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Neuroscientific Foundation of Program Comprehension (Brains On Code)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2499023.0
EU funding (EUR): 2499023.0
Participants: 1
Project status: SIGNED

The pivotal role of software in our modern world mandates strong requirements on quality, correctness, and reliability of software systems. In software development and maintenance, the ability to understand program artifacts plays a key role for programmers to fulfill these requirements. Despite significant progress, research on program comprehension has a fundamental limitation: program comprehension is a cognitive process that cannot be directly observed, which leaves considerable room for misinterpretation, uncertainty, and confounders. In Brains On Code, we will develop a neuroscientific foundation of program comprehension. Instead of merely observing whether there is a difference regarding program comprehension (e.g., between two programming methods), we aim at precisely and reliably determining the key factors that cause the difference. This is especially challenging as humans are the subjects of study, and inter-personal variance and other confounding factors obfuscate the results. The key idea of Brains On Code is to leverage established methods from cognitive neuroscience to obtain insights into the underlying processes and influential factors of program comprehension. Brains On Code will pursue a multimodal approach that integrates different neuro-physiological measures as well as a cognitive computational modeling approach to establish the theoretical foundation. This way, Brains On Code will lay the foundations of measuring and modeling program comprehension and offer substantial feedback for programming methodology, language design, and education. Addressing longstanding foundational questions such as "How can we reliably measure program comprehension?", "What makes a program hard to understand?", and "What skills should programmers have?" will become into reach. A success of Brains On Code would not only help answer these questions, but also provide an outline for applying the methodology beyond program code (models, specifications, etc.).

Keywords: program comprehension,empirical software engineering
Establishing design rules for creating collagen-like materials with specific mechanical stability and response (COLMEC) (COLMEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 4
Project status: SIGNED

Every day, our bodies endure myriad mechanical forces that influence proteins, especially collagen, at the molecular level. COLMEC aims to use collagen as a model to uncover the nuances of protein mechanochemistry. A central aspect of this research is deciphering how collagen's evolutionary adaptations influence its response to forces, especially in contexts of aging and disease. This pursuit is split into three distinct objectives: (1) investigating the coevolution of collagen's amino acid residues to decode its response to tensile forces; (2) delving into the role of metal ions in collagen crosslinking, drawing parallels with natural phenomena such as the resilience of mussel byssus; and (3) probing the mechanisms of force propagation within collagen's varied structures. Merging bioinformatics, computational biophysics, and materials science, COLMEC's interdisciplinary approach illuminates how evolution shapes protein defenses against mechanical strains. This knowledge is pivotal in establishing design rules for crafting synthetic collagen-like materials with tailored mechanical stability and response, bridging evolutionary insights with innovative material design.

Keywords: mechanically active proteins,mechanochemistry,collagen,mechanoradicals,protein coevolution
BAYesian Inference with FLEXible electronics for biomedical Applications (BAYFLEX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,France
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2026-09-30
Duration (months): 42.0
Total project cost (EUR): 3204941.5
EU funding (EUR): 3204941.5
Participants: 9
Project status: SIGNED

The long term vision in BAYFLEX is to create a radically new technology that uses low cost, green organic electronics for probabilistic computing in order to allow continuous and private monitoring of bio-signals on flexible substrates. The vision of flexible green AI sensors with on chip classification extends well beyond biomedical devices and the democratization of health care, with the possibility to transform sensor data at the edge of large networks. To achieve our goal, BAYFLEX will demonstrate a patch using active physiological sensors based on organic materials that interface with the soft human body and that also includes classification circuits (~ 100 transistors) fabricated using Thin Organic Large Area Electronics (TOLAE) processes. These circuits use spiking neurons realized in Organic Thin Film Transistors (OTFTs) to transform the non-stationary electrical signals from the sensors into stochastic bit streams. Bayesian inference is then used to classify the data using circuits of cascaded Muller C-elements. Taking advantage of the unique properties of organic electrochemical transistors (OECTs), low transistor count dynamic Muller C-elements are targeted. The patch will be tested on a simple task using healthy humans. The project brings together an interdisciplinary consortium with expertise in modeling emerging devices, biologically inspired circuit design, experts in machine learning involving electrophysiological data (including an SME) and teams with expertise in OTFT and OECT fabrication. BAYFLEX targets dissemination to a variety of publics including: scientists via publications in (open access) high impact journals and conferences; industrials and end-users through an industrial advisory board, a workshop and demonstrations at targeted conferences; the general public with the creation of a transferable workshop for non-scientific communities and training the next generation of experts through specialized schools and workshops.

Keywords: bayesian inference,flexible electronics,eeg,stochastic computing
Moving cell-based immunotherapies to fight bacterial lung infections into the clinics (iMAClung)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Harnessing the immune system to combat global diseases has introduced a new era in modern medicine. The iMAClung proposal will extend this concept and will pave the way for the first immune cell-based therapy to combat bacterial airway infections. With more than 2 million deaths around the world in 2020, lower respiratory tract infections are still the deadliest communicable disease with unmet medical need, highlighting the necessity for radical new approaches to develop therapeutic avenues. The iMAClung proposal aims at the adoptive transfer of human macrophages directly into the infected lung and to restore the endogenous alveolar macrophage (AM) cell pool to efficiently resolve bacterial airway infections and to mediate lung regeneration at the same time. iMAClung will harness the unique features of induced pluripotent stem cells (iPSC) to use macrophages (iMonoMac) as a cell-based immunotherapy following the adoptive transfer of these cells directly to the side of pulmonary infection. iMAClung is built upon the pioneering work of the ERC-Stg “iPSC2Therapy”, in which the anti-bacterial activity of iMonoMac against a variety of pulmonary (myco)bacterial infections has been successfully demonstrated in vivo. In addition, “iPSC2Therapy” has also successful shown the first scalable production of “off-the-shelf” iMonoMac using industry compatible bioreactors, which now paves the way for the development of seminal (non)therapeutic concepts. To enable clinical transfer, iMAClung will build a team of medical, scientific and industrial experts, all dedicated to bring iMonoMac into humans. To enter the next stage of the clinical translation pipeline, a path towards the clinics will be developed, which will facilitate subsequent exploitation and transfer into patients. iMAClung will bridge the seminal therapeutic concept from bench to bedside, having broad value for patients, society, medical personal, and the healthcare/biopharmaceutical industry within Europe and beyond.
Social INnovation to FOster iNclusIve Cooperative, connected and Automated mobility (SINFONICA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Greece,France,Italy,Germany,Netherlands,Belgium,United Kingdom
Call: Analysis of socio-economic and environmental impacts and assessment of societal, citizen and user aspects for needs based CCAM solutions (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3759723.75
EU funding (EUR): 3759723.75
Participants: 14
Project status: SIGNED

SINFONICA aims to develop functional, efficient, and innovative strategies, methods and tools to engage CCAM users, providers and other stakeholders (i.e. citizens, including vulnerable users, transport operators, public administrations, service providers, researchers, vehicle and technology suppliers) to collect, understand and structure in a manageable and exploitable way their needs, desires, and concerns related to CCAM. SINFONICA will co-create final decision support tools for designers and decision makers to enhance the CCAM seamless and sustainable deployment, to be inclusive and equitable for all citizens.

Keywords: society,users,co creation,accessibility,public transport,rural mobility,urban mobility,acceptability,expectations,needs,recommendations,knowledge,inclusiveness,user centred,accessibility
CROSS-SECTORAL ALLIANCE AS THE KEY FOR INNOVATION-DRIVEN BUSINESS SUCCESS OF ESTONIAN AND GREEK REPRODUCTIVE HEALTHCARE (NESTOR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Estonia,Greece,Netherlands
Call: Fostering balanced brain circulation – ERA Talents (HORIZON-WIDERA-2022-TALENTS-03, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2996625.0
EU funding (EUR): 2996625.0
Participants: 8
Project status: SIGNED

Constantly decreasing infertility rates and low success rates of in vitro fertilization (IVF) associated with the advanced age of couples create challenges in reproductive medicine. It is crucial to fill the existing gaps to unlock the socioeconomic benefits and boost the commercial viability of reproductive medicine in Europe. The gap in access to excellence is especially witnessed in Widening countries such as Greece and Estonia, where the academic sector is lagging behind, producing a low volume of commercialised innovations and low-quality clinical services. It poses obstacles in creating competitive positions for highly talented specialists with career perspectives and a strong interest in boosting local reproductive medicine, stimulating the brain drain, and minimizing life-long learning opportunities. The contribution of the NESTOR project to solving these challenges is aimed at improving the research and innovation performance of institutions involved in reproductive medicine by boosting the collaboration between industry and academia in Widening and non-Widening countries through cross-sectoral and international mobilities. The NESTOR consortium consists of 8 partners from academic and industry partners from the Netherlands, Greece, and Estonia, ensuring the knowledge transfer and advancement in four key reproductive medicine modalities for the reproductively aged population: personalised medicine solutions, IVF embryo and uterine health studies, and novel non-invasive prenatal testing technologies. In total, NESTOR will engage 23 ERA Talents from the Widening Countries, boosting their research skills, nurturing their innovative and entrepreneurial mindset, and providing them with other transferable skills. The well-tailored secondment methodology is aimed at raising their research profiles, improving their career perspectives and opportunities for life-long learning, which will help reverse the brain drain in the long term.

Keywords: reproductive biology,reproductive medicine,
ExplorinG by in situ and operando techniques the native dEgradation MechanIsms and longe range propagatioN In metal halide perovskite (GEMINI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2499079.0
EU funding (EUR): 2499079.0
Participants: 1
Project status: SIGNED

GEMINI aims to advance fundamental understanding about the halide perovskite structure dynamic subsequently to photons absorption and how the latter can seed the early stage degradation. The state-of-the-art overflows of comparative ex situ analysis before and after ageing. This approach does reveal neither information on early stage degradation nor relevant information on their propagation. GEMINI has the ambition to fill in this understanding gap through a holistic approach to cover the multiscale degradation facets. For this, specific developments are integrated, in particular a table-top time-resolved X-ray scattering diffractometer to explore ultrafast structural dynamic in lab. GEMINI addresses all drawbacks of ex situ analysis and the constrains of the perovskite sensitiveness to high probe dose or high vacuum which itself contribute to the degradation. GEMINI will reveal live information resulting exclusively from in situ and operando approaches based on low-dose techniques, through specifically developed sample chambers and setup modifications. Ultrafast time-resolved and electron spin resonance spectroscopies, time-resolved and steady-state X-ray diffraction and live-scanning environmental transmission electron microscopy (STEM) combined to the latest development in 4D-STEM/ASTAR are combined to gather comprehensive multiscale information about degradation upon all relevant ISOS stressors, one at once and in combination to assess the synergetic effects. GEMINI is built upon solid background competences with these advanced techniques to ensure impacts beyond the state-of-the art (SoA): (i) understanding perovskite structural dynamic and relaxation upon photo-excitation down to 1ps time scale, (ii) revealing the multiscale degradation pathways from seeds to long-range depending on ISOS stressors, (iii) networking with EU funded projects in the field to go beyond SoA materials analysis and implement predictive model for ageing.

Keywords: photovoltaic,degradation reactions
Epigenetic regulation of host factors in viral infections (EPIVINF) (EPIVINF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,Italy,Germany,Malta
Call: Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2) (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 6932308.75
EU funding (EUR): 6932308.0
Participants: 6
Project status: SIGNED

The EPIVINF project aims to gain a deep understanding of how acute viral infections alter the epigenetic regulation of host factors that are critical for immune control and neurological health. In particular, EPIVINF will address how acute viral infections impact epigenetic control of host proteins that drive virus-associated disease and/or are involved in the antiviral immune response and how such persistent, epigenetic marks are related to long-term disease evolution. EPIVINF will focus on two major human viral infections, HIV and SARS-CoV-2, both pathogens that affect millions of people around the world and which, despite well-known differences, share some intriguing features that demand further research. We hypothesize that a) defining individuals personal epigenetic profiles, b) assessing how they impact on the innate and adaptive immunity and c) analysing epigenetic control mechanisms in two different viral infections (HIV and SARS-CoV-2), will provide important insights into how different individuals react to different viral infections, how different infections may share similar mechanism that impact on the long term health outcomes, how these processes define the further disease course and, finally, how they could serve as targets for novel therapeutic interventions. To achieve these goals, we will use an panel of cutting-edge epigenetic analyses, immune monitoring tools, disease-relevant animal models, samples from unique human vaccine trials and integrated biosystems analyses to gain a deep understanding of how viral infections harness epigenetic mechanisms to change the adaptive and innate immune phenotype of infected individuals, not only during acute stages of the infection but potentially for live. The study includes extensive patient follow-up to identify factors that predispose to different clinical symptoms and disease progression.

Keywords: epigenetics,sars cov 2,hiv,dna methylation,epidrugs
RondelO - the first medical stopcock designed for sequential intraveneous infusion of incompatible drugs (RondelO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2025-04-30
Duration (months): 30.0
Total project cost (EUR): 2773975.0
EU funding (EUR): 1941782.0
Participants: 1
Project status: CLOSED

CYTO365 is developing RondeO® - a revolutionary medical stopcock to be used with intravenous drug administration sets (IV sets). RondelO® is the first medical device that allows for a sequential intravenous administration of up to 6 drugs with the neutral saline in between the drugs. RondelO® aids the nurse to administer drugs to the patient safely and correctly, by letting only one drug pass at a time. It solves the problem of serious side effects caused by drug incompatibility by eliminating human error and unwanted parallel infusion and thereby increases patient safety. Moreover, RondelO® is easy to use (minimal training required), safe for the user (Closed System Valve (CSV) minimizes hazardous drug expose for the nurse), customizable (different configurations with 2, 4 or 6 drug inlets with or without CSV available) and time-efficient (all drugs are connected to IV set at the beginning of the procedure).

Keywords: intravenous medical device,intravenous infusion set iv set,sequential drug infusion,drug incompatibility
Balancing clean Water and Energy provision under changing climate and eXtremes (B-WEX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Providing clean water and energy simultaneously to a growing global population and under a changing climate is a major challenge. The demand for the two and their systemic interdependencies are particularly strong during droughts and heatwaves. Despite the recent growth in water-energy nexus studies, there is little fundamental understanding of the cascading effects and feedbacks between water and energy systems during extreme weather events. Because existing global model approaches mainly focus on whole-system optimisation and are based on coarse spatiotemporal water and energy system representations, we lack understanding on how water-energy system processes cascade in time and space under a changing climate and extremes. Yet such understanding is urgently needed so that we can balance clean water and energy provision in our changing world in which climate shocks are increasing. In B-WEX, I will develop spatially explicit pathways that reveal how the provision of clean water and energy can be balanced under various water management and energy transition developments, including the feedbacks and cascading mechanisms under present to future droughts and heatwaves in regions worldwide. With my team, I will build a novel global framework which will be the first to integrate high spatiotemporal resolution models of hydrology, water quality, water use and energy systems to estimate how water and energy system processes cascade in time and space. Together with key actors, we will also develop quantitative water management and energy transition (climate action) pathways, which we will then combine with our new framework, enabling us to estimate trade-offs between water and energy systems during present to future droughts and heatwaves. The B-WEX project will greatly deepen our understanding of the cascading effects and feedbacks between clean water and energy systems development that occur under changing climate and extremes, and including climate mitigation actions.

Keywords: water energy nexus,global water scarcity,energy transition,drought,heatwave,climate change,pathways,modelling,spatiotemporal analysis,cascade,feedback