Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using chemical-biology to synthesis and study nuclear receptor proteins (CHEMBIONMR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

The rapidly growing field of Chemical Biology combines the power of synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with parasite glycobiology that has led to a new candidate for a malaria vaccine. Besides infectious diseases, cancer is a major cause of death worldwide and in Europe 2.4 million cases of cancer are reported per year, 50% of which are fatal. In this proposal we present a chemical biology route to propel research in cancer biology forward so that new drug targets can be identified. This global aim will be achieved by using a multidisciplinary approach, which employs peptide synthesis, molecular biology, NMR spectroscopy, X-ray crystallography and other cutting-edge biophysical techniques. This project, which aims to synthesize different ER modified constructs for elucidating comprehensively the role of post-translational modifications in the development of breast cancer and resistance to tamoxifen, would be of high importance for advancing prevention, early detection, monitoring and treatment of the breast cancer disease.

Keywords: chemical biology,chemistry,breast cancer,nuclear receptors,estrogen action,phosphorylation,transcription,protein structure-function,nmr spectroscopy,x-ray crystallography
Enhancing hypnotic suggestibility using noninvasive brain stimulation: Cognitive and neural mechanisms (ENHANCING SUGGESTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2015-01-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Hypnosis is gaining increasing attention as a reliable and effective method for studying a wide variety of psychological and neurological phenomena. It is also a widely-recognized, efficacious form of treatment for pain. A limitation of both the experimental and clinical use of hypnosis is that it is most effective with highly suggestible individuals, who make up approximately only 10-15% of the population. The efficacy of hypnosis coupled with the recognition that it is most effective with a small subset of the population presents a clear motivation for increasing hypnotic suggestibility. The proposed project outlines four experiments that attempt to: 1) examine whether hypnotic suggestibility, as measured by cognitive control tasks, can be enhanced using transcranial direct current stimulation of frontal and parietal cortical regions; 2) investigate the regional haemodynamic and neurochemical changes underlying increases in hypnotic suggestibility; and 3) extend this approach to enhancing hypnotic analgesia during exposure to a nociceptive (painful) stimulus. The proposed project aims to combine non-invasive brain stimulation and functional neuroimaging techniques in novel ways to enhance hypnotic suggestibility and measure the neural basis of this increase. The project will also make a number of unique and important analytic advances by utilizing a variety of statistical techniques including response time distribution modelling, response time series analysis, and mediation analysis, which will provide a more refined understanding of the cognitive and neural mechanisms involved in the enhancement of hypnotic suggestibility. The expected results will have important implications for the experimental utilization of hypnosis in experimental psychology and cognitive neuroscience. The results should also be greatly informative to the clinical use of hypnosis in the treatment of pain and other psychological and neurological conditions.

Keywords: hypnosis,hypnotic suggestibility,brain stimulation,cognitive control,attention,pain,nirs,mrs,prefrontal cortex,parietal cortex,response time modeling
Transport Properties of Ion-Beam Shaped Metallic Nanowires in Vertical Geometry (TAPIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-06-06
End date: 2014-06-05
Duration (months): 24.0
Total project cost (EUR): 201932.4
EU funding (EUR): 201932.4
Participants: 1
Project status: CLOSED

The study of the transport properties of nanowires grown by bottom-up approaches is a fundamental step toward their technological integration into a real device. Their integration into complex electronic devices by simple and controllable methodologies is the key issue to achieving the evolutionary progress that should permit to improve computers and communication systems such that they offer superior performances and enhanced miniaturization associated with increased computational speed, tera-bit storage capacity, ultra-low energy consumption, and reduced costs per function. The final goal of the TaPIR project is to explore new areas of this research field creating new scientific possibilities beyond the boundaries of conventional technologies and applications. The TaPIR project focuses on a threefold objective: i) developing a novel nano-engineering technique -the so called ion-beam shaping technique- to transform embedded metallic spherical nanoparticles into prolate nanorods and nanowires, with an aspect ratio that can be tuned by the ion type, energy and ion beam fluence, ii) to contact them in a vertical geometry and iii) to study their transport properties both from the spin-dependent and from the mesoscopic point of view. The originality of the work proposed resides in elaborating a unique combination of ion-irradiation, colloidal chemistry and nanostructuration techniques to obtain and to study contacted ion-shaped NPs in a vertical configuration. In this respect, our approach is certainly unique and must be considered as an innovating and hitherto unexplored pathway to produce configurations of contacted NPs that are not accessible by merely standard techniques. Furthermore, the project represents an exceptional opportunity to yield new insights within the field of the transport properties of materials at the nanoscale.

Keywords: transport properties at nanoscale,spinstronics,ion irradiation,experimental physics,electronic,magnetic and superconductive properties,radiation physics
The influence of multiple global change stressors on marine communities: a novel field approach (CC AND MARINE LIFE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-08-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Marine habitats are socially and economically important to millions of people around the world, but accelerated global climate change poses a significant threat to aquatic organisms and communities. Accurate predictions of the effects seawater warming and other stressors on marine resources are needed to successfully manage our seas and plan for future change. Of all the facets of global change, increasing temperature is perhaps the most important, as temperature affects all biological processes. In terrestrial systems, researchers have used polytunnels and cloches to manipulate climate to investigate the effects of warming on community structure, dynamics, and biodiversity. There have been no such experiments conducted in the marine realm. As such, a major knowledge gap relates to the lack of field-based experiments conducted on marine organisms to date, and most knowledge stems from highly artificial laboratory manipulations. This project will employ a novel technique to manipulate temperature in situ, to examine the effects of warming on marine communities on hard surfaces. The ‘hot-plate’ technology has been developed in Australia over the last 2 years, and has facilitated the first controlled manipulation of temperature in a marine habitat. This project will support transfer of knowledge, facilitate further development of this technology, and allow comparative experiments to be conducted in both Australia and Europe, thus enhancing the ecological relevance of the work. Warming experiments will be combined with simultaneous manipulations of other global change stressors (sedimentation, nutrients, physical disturbance, seawater chemistry) to investigate the effects of multiple factors on the recruitment, growth and development of marine communities. The research has important implications for ecological theory and conservation, as well as industrial practises such as biofouling management and aquaculture.

Keywords: natural sciences,marine ecosystems (climate change),aquatic ecology,community ecology,marine benthic assemblages,coastal biodiversity
Neighbouring China. Ancient crossroads, new connections, and the dynamics of Asian Regionalism. (NEIGHBOURING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

This research is concerned with the effects of China's rise on its immediate neighbours – the communities and ethnic groups living along its borders. Over the past two decades, most of the border disputes between China and its neighbours were settled. The Party State has since begun to pursue a strategy of active engagement with its neighbouring states. This strategy includes fostering cross-border trade, efforts to obtain access to natural resources, and increasingly tight security along the borders in order to manage potential unrest. These policies have created new opportunities but also new restrictions. Rising China – the nation, the notion, the buzzword – channels aspirations and triggers fears. The borderlands surrounding China, once unruly frontier zones between empires and junctures of ancient trade routes, have again acquired geopolitical relevance – as pathways of the global economy's flows of raw materials, goods, and people, and as hotspots of ethnic tension. They are the joints that hinge Asia as a region together, and they serve as testing grounds for China's extraterritorial "special zones" and development-cum-investment deals (which, with Hungary signing such a deal in July 2011, have now also reached Europe). This study is the first to conceptualise the territories bordering China as a coherent geographic configuration. It transcends the traditional boundaries of area studies in order to analyse the dynamic re-making of Asia and its growing significance in the world. Taking border regions instead of nation states as a starting point, the project develops the notion of "neighbouring" as an analytic lens to comprehend the changing nature of borders in the 21st century. The applicant has carried out research in the Sino-Russian and Sino-Nepalese borderlands. During the fellowship he seeks to extend his expertise to a third Central Asian field site, for which the host institution is among the leading research centres in Europe.

Keywords: social sciences,cultural anthropology,social anthropology,geopolitics,human geography,history,humanities,border studies
Plasmonically-enhanced Quantum Dot Photodetectors (PEQUPHOT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 176053.2
EU funding (EUR): 176053.2
Participants: 1
Project status: CLOSED

Plasmonics has received a lot of attention because of the unique optical properties of metal nanostructures that allow, for example, strong focusing of light and strong field enhancements. While plasmonics is widely proposed for improving performances of optoelectronic devices, its applicability still has to be proven. Photodetectors are well-established for different applications ranging from digital photography to biomedical imaging. However, because of their versatile use there is a great demand for low-cost devices. One way to achieve low-cost photodetectors is by employing solution-processed quantum dots as active material. Quantum dots are a promising medium because of the tunability of the absorption spectrum by varying their size due to the quantum confinement effect and because of the low-cost fabrication technique due to their solution processability. However, the performance of quantum dot photodetectors has been limited so far to either being ultra-sensitive, but rather slow, or high-speed with a low sensitivity. We will break this compromise by concentrating light into nanoscale semiconducting volumes by employing plasmonic structures. Therefore, we will numerically simulate the interaction between the incident light, the plasmonic structure, and the absorbing quantum dots, by using commercial simulation software. In a next step, we will fabricate the plasmonic structures and we will determine an optical absorption enhancement by measuring the photoluminescence of the quantum dots in the vicinity of the plasmonic structure. In a final step, we will fabricate the actual photodetector and characterize its performance by optoelectronical measurements.

Keywords: opto-electronic components,photonic components,plasmonics,quantum dots,photodetectors
Embodied Approaches to Social Cognition: Empathy and Perception (EASCEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

Successful social interaction is the key to all aspects of our modern life, from everyday activities to highly complex cultural, technological, and economic phenomena. One central research question, spanning philosophy, psychology, neuroscience, psychiatry and anthropology, therefore is: how do we understand other human beings? The project proposes to address the issue by developing an original theoretical framework which focuses on basic forms of understanding other minds by understanding the others’ embodied intentionality or skilful bodily engagement with the world. The goal is to develop a theory of basic forms of intersubjectivity as active engagement between embodied social agents and to clarify the dependency of understanding others on one's own abilities of interaction. The central hypothesis of the project is that there is an immediate form of understanding other minds by understanding the others’ embodied intentionality which draws upon one’s own interaction abilities. The project discusses two intertwined themes, namely, the phenomenon of empathy and the role and mechanisms of perceptual cognition in enabling an immediate understanding of the other’s embodied intentionality. The project combines philosophical analyses with discussions of empirical studies primarily in psychology and neuroscience to address two main themes: 1) uncover the nature of the phenomenon of empathy as an immediate experiential access to other minds by understanding the other’s embodied intentionality and identify its possible cognitive mechanisms with special focus on mechanisms of action-understanding drawing on one’s own interaction abilities, 2) understand the significance of one’s perceptual knowledge of the other’s embodied intentionality for attributing mental states to the other by focussing on the mechanisms of perception-action coupling. Thus the project will investigate social cognition as an active engagement of an embodied social agent in enabling social interactions.

Keywords: humanities,social cognition,philosophy,psychology,neuroscience
Language learning in monolingual and bilingual infants: Evidence from electrophysiological and optical signals (INFANTBILINGUALBRAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 180191.4
EU funding (EUR): 180191.4
Participants: 1
Project status: CLOSED

Bilingual infants have to deal with two languages at the same time. Some previous studies showed delayed processing in bilinguals due to the higher cognitive load they are faced with. However, other studies show that they master this challenging task with a fascinating ease and at the same pace as monolingual infants. In order to get clearer insights into language learning processing mechanisms in mono- and bilingual infants we will adopt a statistical learning paradigm in which 6 and 18 month old infants listen to phonotactically legal and illegal pseudowords presented in combination with different pseudoobjects. Phonotactics is a prelexical cue relevant for segmentation and lexical access and thus playing a crucial role during word learning. Legal phonotactic rules will correspond to German, whereas illegal rules will correspond to the Slovak language. Monolingual infants will have German as their native language and bilingual infants will be confronted from birth with German and Italian. Thus, the experimental material reflects processing of the native language compared to a foreign language rule. In order to be able to differentiate fine-grained language learning mechanisms we will adopt simultaneously two neuroscientific methods: the electroencephalography (EEG) and the functional near-infrared spectroscopy (fNIRS). The former allows an exquisite temporal resolution aiming at identifying temporal characteristics of fast processing mechanisms and the latter will focus on topographic issues, especially on lateralization. The research questions of the present study focus on whether bilinguals are more flexible learners than monolinguals providing superior learning abilities with respect to a new language or whether a word-object associative learning context provides a more laborious learning setting and thus leading to delayed and differential processing mechanisms, both on a temporal level as well as with respect to recruitment of differential brain areas.

Keywords: neuropsychology,pediatrics,neurolinguistics,psycholinguistics,cognitive science
Ricochet Effects: Global Circulations of Cultural Memory Debates (RICOMEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Duration (months): 24.0
Total project cost (EUR): 252264.0
EU funding (EUR): 252264.0
Participants: 1
Project status: CLOSED

The aim of this project is for Dr Alison Ribeiro de Menezes to go from University College Dublin, Ireland, to Brown University, USA, for a period of 1 year to gain new expertise in memory debates and cultural exchanges in the Portuguese and Spanish-speaking worlds. She will transfer this to Ireland during a return year of training at University College Dublin, thereby developing a new understanding within the ERA of the global circulation of memory debates. The project addresses memory’s global migrations by shifting attention from nationally based perspectives to a multi-lingual and multi-continental view. Knowledge of identity and memory debates in the Lusophone world (including Portugal, Brazil, Angola, Mozambique, and East Timor) and of Hispanic transatlantic exchanges (particularly between Spain, Argentina, and Chile) gained at Brown will be used to develop a ‘ricochet’ model of transnational cultural exchange. The research foregrounds the contingency of exchange processes involved in memory formation, de-formation, and re-formation; explores the lessons, for the advancement of national and international justice, of the vernacularization of human rights discourses and their role in promoting memory’s cross-cultural migrations; and seeks re-centre cultural memory studies by exploring multidirectional memory in a Luso-Hispanic perspective in order to supplement and deepen prevailing Franco-German theoretical models. Through knowledge transfer activities in the incoming phase, the project will facilitate mutual exchanges between researchers and policy makers in the fields of memory, rights and retrospective justice in the ERA and so enhance research excellence and bridge links between academia and practitioners.

Keywords: cultural memory,lusophone studies,hispanic studies,democratization,human rights law,international relations,globalization processes,colonial history,cultural studies,literature.