Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technological Variability during the Late Pleistocene in Eastern Africa: lithic assemblages as indirect witnesses of past human population dynamics (PleisTechnoVar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

PleisTechnoVar aims to better understand the increase in technological variability observed in Africa during the Late Pleistocene, between 70000 and 15000 years ago. While many research projects have focused on the origins of Homo sapiens and its spread Out of Africa into Eurasia, fewer research has concerned the material cultures of the populations who « stayed » in Africa and how they interacted with eachother. The first objective is to study this variability on the regional scale of Eastern Africa, between Kenya and Ethiopia. The second objective is to develop a methodological approach to understand the factors driving this variability. A larger scale of analysis will be used and Eastern Africa as well as the Nile Valley and the Levant will be considered in order to propose hypotheses concerning links between technological variability, environments and population dynamics. This project is an in-depth study of the candidate's previous research axes in these regions. In order to meet these objectives, lithic assemblages will be studied using the concept of chaîne opératoire and attribute analyses. Data collection will take place during short mobilities in museums in Eastern Africa, Israel and Europe. Spatial analyses will complete the study. These data will then be discussed in view of the known palaeoenvironmental data, as well as the results from the study of other types of material (zooarchaeology, geomorphology, etc.). The research will be conducted at the McDonald Institute for Archaeological Research in the University of Cambridge where the candidate will receive high level training to improve her skills in the study of material culture (quantitative and qualitative data, theoretical background), as well as to develop new competences in spatial analysis (through the use of Geographic Information Systems (GIS)). The candidate will greatly benefit from the host organisation's experience in interdisciplinary research on the diversity of material cultures.

Keywords: lithic technology,eastern africa,middle stone age,later stone age,migrations,technical transitions
Quasi-random hypergraphs (QuasiHyp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2022-04-18
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

This project concerns research on the frontier between discrete mathematics and computer science, and focuses on studying properties of randomly behaving discrete structures. Specifically, it studies quasi-random properties of k-uniform hypergraphs by using a combination of hypergraph regularity methods and flag algebras. The properties the project will be mainly focused on are containments and counting small substructures in large quasi-random hypergraphs. These questions are closely related to problems from other areas such as number theory, algorithm design, and property testing.

Keywords: extremal combinatorics,quasi randomness,regularity method,limits of discrete structures,hypergraphs,flag algebras,computer assisted proofs
Mitotic Bookmarking, Stem Cells and early Development (BinD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1900843.75
EU funding (EUR): 1900843.75
Participants: 1
Project status: SIGNED

The goal of this proposal is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are currently not considered to directly contribute to the mitotic inheritance of chromatin states. Instead, these are passively propagated through cell division by a variety of epigenetic marks. Recent discoveries, including by our lab, challenge this view: developmental TFs may impact the propagation of regulatory information from mother to daughter cells through a process known as mitotic bookmarking. This hypothesis, largely overlooked by mainstream epigenetic research during the last two decades, will be investigated in embryo-derived stem cells and during early mouse development. Indeed, these immature cell identities are largely independent from canonical epigenetic repression; hence, current models cannot account for their properties. We will comprehensively identify mitotic bookmarking factors in stem cells and early embryos, establish their function in stem cell self-renewal, cell fate acquisition and dissect how they contribute to chromatin regulation in mitosis. This will allow us to study the relationships between bookmarking factors and other mechanisms of epigenetic inheritance. To achieve this, unique techniques to modulate protein activity and histone modifications specifically in mitotic cells will be established. Thus, a mechanistic understanding of how mitosis influences gene regulation and of how mitotic bookmarking contributes to the propagation of immature cell identities will be delivered. Based on robust preliminary data, we anticipate the discovery of new functions for TFs in several genetic and epigenetic processes. This knowledge should have a wide impact on chromatin biology and cell fate studies as well as in other fields studying processes dominated by TFs and cell proliferation.

Keywords: transcription factor,mitotic inheritance,gene regulatory network,pluripotency
Structural and Functional Architectures of Multi-Kingdom Microbial Consortia Colonizing Plant Roots (MICRORULES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 1497547.0
EU funding (EUR): 1497547.0
Participants: 1
Project status: CLOSED

The roots of healthy plants are colonized by a rich diversity of microbes, forming multi-kingdom microbial consortia that impact plant productivity. Despite the expected high connectivity between root microbiota members, our understanding of microbe-microbe interactions in structuring microbial networks in plant roots as well as their functional impact on plant growth remains poorly understood. Based on recent findings in my group, I propose a conceptual framework aiming at a functional understanding the holo-plant microbiome, where microbial interactions play an integral role in structuring root-associated microbial communities and maintaining microbiota balance and plant health. By profiling three independently-evolved microbial classes (bacteria, fungi, oomycetes) in the roots of natural Arabidopsis thaliana populations across Europe and establishing corresponding reference culture collections for subsequent reconstitution of the plant microbiota in vitro, I will define fundamental mechanisms underlying the structure and functions of the plant microbiota. I will generate and utilize extensive microbial genome resources for the interpretation of metatranscriptome profiles of multi-kingdom synthetic communities during root colonization. This will contribute to a transition from binary plant-microbe to community-level molecular investigations. Finally, using a genetically tractable tripartite interaction model between the non mycorrhizal plant A. thaliana, a beneficial fungal root endophyte and a rhizobacterium, I propose to functionally dissect the molecular basis of beneficial multitrophic plant-microbe interactions by identifying microbial genes that are essential for both microbe-microbe and microbe-host interactions. My hypothesis-driven research applies innovative reductionist approaches to reconstitute the microbiota of plant roots in laboratory settings to identify fundamental assembly rules and mechanisms that underpin complex plant-microbe interactions.

Keywords: plant microbiome,microbial interactions,microbial genomics
A Unique Herbal Product for the Symptomatic Treatment of Over Active Bladder (SAGAPROPLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Iceland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Overactive bladder (OAB) is an emerging condition that significantly impacts the quality of life and daily routine of millions of people. It is characterized by urinary urgency, increased urinary frequency and nocturia. OAB is extremely frequent, affecting more than 500 million people worldwide and its prevalence is expected to increase by 9,2% by 2018. Despite being a widely spread affection, currently there is no effective treatment in the market, and the ones available are associated to adverse reactions and drug-to-drug interactions, leading to up to 88,6% of dropout cases. As a consequence, the market trend is shifting from prescription drugs to products from natural origin. In the recent years, there has been a strong increase in the market for herbal medicinal products in Europe which is looking forward to bio-based solutions. These facts open up a clear opportunity for alternative solutions like the ones developed by SagaMedica, an Icelandic company with 17 years of experience in the field of natural product manufacturing. At SagaMedica we have developed SagaPro+, the first new natural product for improving OAB symptoms in decades. It is made from an extract of the leaves of Angelica archangelica, whose activity on the bladder was discovered by SagaMedica’s research team. We have developed a harvesting, extraction and manufacturing process system that has been kept sustainable and eco-friendly. SagaPro+ provides several advantages compared to current alternatives: 1) Highly effective product, as it has been reported by clinical trials; 2) It has no adverse effects nor drug-to-drug interactions; and 3) It is based in a natural product from a sustainable production and harvesting system, contributing to Europe´s bio-based economy. All these reasons brought high interest of various companies, with cooperation discussions already progressing with three strong players. Several Support Letters prove this market demand.

Keywords: food supplement,natural therapy,urinary health,over active bladder,health and wellbeing,herbal product,bio based process,bio based economy,sustainable harvesting
Malta EU Presidency MSCA 2017 Conference: Enhancing RI capacity through researchers’ mobility (MSCA 2017)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Coordination and support actions
Countries involved: Malta
Call: Presidency conference(s) (H2020-IBA-MSCA-Presidency-2017, 2017)
Start date: 2016-12-01
End date: 2017-09-30
Duration (months): 10.0
Total project cost (EUR): 181500.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The MSCA 2017 Conference will take place in Malta on 11th and 12th May 2017 under the auspices of the Maltese EU Presidency to the Council of the EU. The event will focus on ‘Enhancing R&I capacity through researchers’ mobility’ and will be organised by the Malta Council for Science and Technology of the Ministry for Education and Employment, with the collaboration of the University of Malta. The overall objective of the conference is to discuss and reflect on the Marie Skłodowska-Curie Actions with a special focus on ‘Enhancing R&I capacity through researchers’ mobility’. The objectives of the event will be reached by sharing of good practices and encouraging a debate on past and ongoing experiences. Experienced and early stage researchers, academics from various universities, European Commission officials, proposal evaluators, representatives of National Contact Points and Programme Committee Meetings will have the possibility to share good practices, views and opinions. The input from the participants will be then elaborated into a conference report. The event will also look into other current and future aspects of the MSCA programme such as ‘Widening Participation’, in terms of encouraging organizations and researchers from the EU 13 to increase their participation in the MSCA. The role of policy makers, research institutions, non-academia sector, and National Contacts Points in this regard will be addressed. Furthermore, the conference will also highlight current and future societal challenges in order to prepare researchers for an attractive career and knowledge-exchange opportunities. The interaction between academia and industry sectors, skills, mobility, and gender issues will be among the key elements. A total of 150-200 participants are foreseen.

Keywords: msca malta eu presidency conference
Extending the applicability of Cryo-EM for fragile biological systems via ultra-pure cryo-samples from Preparative Native Mass Spectrometry (PNMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Precise structural, conformational, as well as chemical information of biological molecules forms the basis for comprehension and control of biological processes, including metabolism, pathological processes, and drug targeting. Cryo-electron microscopy (cryo-EM) has evolved into one of the leading methods for structural characterisation of folded proteins and protein complexes reaching atomic resolution through averaging. Thus, the unambiguous assignment of thousands of images to different oligomers, conformers, and fragments is a key requirement for high-resolution single particle cryo-EM. However, reliable preparation of homogeneous cryo samples remains one of, if not the, most important challenge in cryo-EM. Native mass spectrometry (native MS) allows to retain proteins in a near native state in an ultrapure gas-phase molecular ion-beam, providing complementary information on mass, composition, conformation and ligand binding sites. Preparative mass spectrometry (prep-MS) is able to generate ultrapure samples by soft landing of mass- and conformation selected molecules on surfaces for subsequent analysis. Here, we propose to implement preparative native mass spectrometry (pnMS), combining the strengths of native MS, prep-MS, and cryo-EM, to establish a new versatile pathway for comprehensive structural analysis of biological systems. We will design ion optics to couple a mass selected molecular ion beam from a commercial high-performance MS and a landing stage to add deposition capability. Initial experiments will focus on benchmark systems such as BSA and GroEL, before approaching more challenging proteins, including heat shock proteins (HSPs) and G-Protein coupled receptors (GPCRs). Ultimately, pnMS should enable the structural biology community to obtain a comprehensive understanding of structural variety (proteoforms), protein interactions (interactome), and synthetic structures, e.g. needed for customised medicine.

Keywords: cryo transmission electron microscopy ion beam deposition soft landing scanning probe,microscopy mass spectrometry mambrane proteins heat shock proteins g protein coupled receptors
Developmental scaling of cell mechanosensitivity in epithelial tissue (Scaling-Sensitivity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2132471.0
EU funding (EUR): 2132471.0
Participants: 1
Project status: SIGNED

All biological systems tailor their organization and properties to their size. Such size scaling is essential to The scaling of biological structures and substructures with their size is a preeminent and essential feature of life. Accordingly, the study of scaling properties had a profound impact on our understanding of animal physiology, gene expression, cell cycle regulation and intracellular dynamics. Their study at the cell level has often led to the discovery of the fundamental mechanisms allowing cells to probe their size or geometry (cell size ruler). Yet we are very far from understanding how such cell size ruler controls more macroscopic processes such as morphogenesis or global tissue size. Building on interdisciplinary methods (live-imaging, genetics, physical modeling, transcriptomics) and on the recent progresses in mechanical force sensing, we aim to understand how cell size rulers are generated in epithelial tissues and how they are modulating in time to account for the spatiotemporal regulation morphogenesis and proliferation of developing organism. More specifically, working from the cell to the tissue levels, we explore how the interplay between two fundamental and prevalent structures, actomyosin stress fibers and tricellular junctions, define an internal cell ruler probing cell size in the control of epithelial morphogenesis, signalling and proliferation. Conversely, we will explore how systemic hormonal or local tissue timers modulate such internal cell rulers to control the temporal regulation of tissue dynamics. Thereby we will understand how tissue and organismal level regulation could impact on cell size rules to control the temporal dynamics of tissues. By focusing on both the genetic and mechanical regulation at different length-scales (cytoskeleton, cell, and tissue) and time-scales (seconds to hours), we expect to provide novel and fundamental insights into the spatiotemporal mechanisms governing the dynamics of biological structures.
High-Voltage High-Current Lightweight Solid-State Protection Circuit for Avionic Applications (H2LSPC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,United Kingdom,United Kingdom
Call: Aerospace standard Lightweight SSPC for High voltage >1kA application. (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-06-01
End date: 2022-03-31
Duration (months): 34.0
Total project cost (EUR): 880978.75
EU funding (EUR): 880978.75
Participants: 4
Project status: CLOSED

This project is about developing and demonstrating a lightweight high-voltage solid-state protection component (SSPC) compatible with aerospace standards. Specifically, a product suitable for electrical architectures with voltage bus higher than 1 kV and current capability higher than 1 kA will be pursued. The proposed solution will incorporate the cooling and thermal management device, as well as the necessary electro-magnetic shielding features required to meet the standards of aerospace applications. To achieve the intended targets, the project will base on a balanced mixture of topological and technological studies and will deliver built-in reliability integrated solutions at the TRL4 level.

Keywords: power electronics,solid state protection component,sspc