Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EUROPEAN SPACE GAN (ESGAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Spain,Germany,France
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2024-SPACE-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 4814880.5
EU funding (EUR): 3370416.35
Participants: 4
Project status: SIGNED

European Space GaN (ESGAN) aims to develop a 200V Enhancement mode GaN transistor (normally off) for use in power management circuits for space applications. The advantages obtained from Gallium Nitride (GaN) such as reduced mass, increased efficiency and the potential of radiation hardness are well known and the project will aim to exploit these in the development of the technology. Devices will be designed, produced, tested for radiation effects, thermal effects, structural effects and reliability performance and will be demonstrated in an application to verify the desired performance. The end goal will be to proceed with a space evaluation leading to a space qualification of the produced devices. Another of the principal objectives is to establish and exercise a fully capable, committed European Supply Chain to remove dependency from other countries and geographical regions. To achieve the goals of the project a strong consortium has been established in which the members cover each of the stages of the supply chain. The consortium is composed of the following companies. AIXTRON, a company dedicated to the design and manufacture of equipment to grow advanced substrates for GaN transistors. SEMI ZABALA, a company dedicated to the design, test and packaging of GaN transistors and integrated circuits. X-FAB, a semiconductor foundry company that has developed and offers processing services for GaN transistors. AIRBUS DEFENCE & SPACE, are one of Europe´s leading companies dedicated to the design and manufacture of satellite equipment and systems. The consortium covers an end to end supply chain from materials, design, processing packaging and test through to end users.

Keywords: gan rad hard space eee components e mode
Responsible prediction of gene expression: mitigating genetic risk profiling (PredicGenX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-08-31
Duration (months): 28.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Environmental factors are crucial to physical and mental health—they impact even the expression of our DNA. The study of epigenetics provides better understanding of gene-environment interaction. Environmental influence can come from outside and inside the organism but one environmental factor that is typically overlooked is people’s knowledge production and beliefs. PredicGenX responds to the scientific worry that predictions about genes are likely to be reflexive i.e., they impact the eventual outcome. Scholars have raised concerns that beliefs about genetic information affects genetic risk to match that information—a so-called self-fulfilling prophecy not unlike the placebo and nocebo effects. Studies showed that receiving one’s genetic risk profile can change physiology independent of actual genetic risk. Moreover, the current trend to focus on risk, biomarkers, and early diagnostics produces 'knowledge' which is inevitably based on undetermined information, given that gene expression is not fixed. Asserting genetic information as determined when the assertion itself has potential impact on genetic expression is especially alarming considering the popularity of direct-to-consumer genetic testing and precision medicine. Understanding the direct impact of genetic predictions on gene-expression, its vulnerability to feedback loops, and their moral implications is crucial, urgent, yet currently lacking. With this project, I aim to fill that knowledge gap. Through qualitative fieldwork and philosophical analysis, I will theorise the different ways in which reflexive (epi)genetic prediction manifests and—while detailing a descriptive account of the different models—offer an analysis of the epistemic and ethical implications of their reflexivity on research and practice, and the meaning for therapeutic intervention.
IDIBAPS Doctoral programme Yielding Novel Advancements in Medicine and Innovative Solutions (DYNAMIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Belgium,Portugal,Netherlands,Austria,Mexico,Norway,France,United Kingdom,Germany
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1584000.0
EU funding (EUR): 1584000.0
Participants: 34
Project status: SIGNED

Addressing the increased need for innovative solutions in medicine requires nurturing and training of highly skilled translational researchers, understanding patients´ needs and driving research to address them, mastering innovative technologies, navigating ethics and regulations, and facilitating interdisciplinary and intersectoral collaborations. The IDIBAPS research institute is uniquely located in the Campus Clínic in Barcelona, joining efforts with the University of Barcelona and the Hospital Clínic, carrying out cutting-edge translational research to improve prevention, diagnosis, and treatment of most common diseases in our society. The novel DYNAMIS programme will train 10 excellent junior translational researchers to carry out original PhD research projects in Translational Medicine. Recruited through two open, merit-based international competitive calls, the Doctoral Candidates (DCs) will benefit from high-quality co-supervision by a more fundamental and a clinical researcher and will engage in a training and career development programme in a vibrant research and innovation environment, opening them up a wide variety of career paths in academia and the private sector. DYNAMIS will offer the highest quality standards of scientific integrity and social responsibility, following the principles of the European charter and code for researchers, and the fundamentals of innovative training. DYNAMIS has partnered with 33 Associated Partners, including hospitals, patient groups, SMEs, health clusters and tech companies to offer training, supervision and secondment opportunities, enhancing the employability of the DCs through inter-sectorial exposure. By the end of the doctoral programme, the DYNAMIS fellows will have gained scientific and transferrable skills, including knowledge and experience on how to incorporate the patients´ perspective in research, to advance their career at the forefront of medicine and science.

Keywords: translational medicine biomedicine technology equality,diversity and inclusion transferable skills international,intersectoral and interdisciplinary training patients engagement innovation
Shower Thoughts About Precision LHC Eventsimulations (STAPLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1022706.0
EU funding (EUR): 1022706.0
Participants: 1
Project status: SIGNED

Our understanding of the universe's fundamental building blocks is primarily determined by measurements in earth-based scattering experiments at high energies like those conducted at the Large Hadron Collider (LHC). The precise comparison between measured scattering cross-sections and first-principle theory predictions allows us to distinguish and constrain different models of microscopic physics. This strategy led to the Standard Model of Particle Physics (SM). Despite the SM's success, there remain open questions related to particle physics: the matter-antimatter asymmetry, the origin and decomposition of dark matter, and the nature of electroweak symmetry breaking. These can be addressed through measurements in high-energy scattering experiments. The data collected at the LHC and future colliders will allow stress testing of the SM. Additionally, reinterpreted, these will constrain new physics to energies far beyond the direct production capabilities. The challenge for theory is to match this precision to take maximal advantage of this potential. Predictions from the SM are derived from perturbation theory in Quantum Field Theory. Including higher orders in the perturbative expansion and all-order resummation systematically improves accuracy. Higher orders in Quantum Chromodynamics (QCD) are especially essential for LHC physics. Accordingly, the European particle physics strategy update recognises precision phenomenology and the corresponding development of techniques and tools as the key to a successful third data-taking period and high-luminosity upgrade of the LHC. STAPLE aims to combine insights from recent progress in second-order perturbative QCD computations and understanding the logarithmic accuracy of parton-shower simulations to develop a precision event simulation at NNLO+PS accuracy. The event simulation will deliver accurate and precise predictions for scattering processes and will be a STAPLE of precision physics at the LHC and beyond.
Efficient & Selective Ion Pumps based on Ratchet Mechanisms (ESIP-RM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1609470.0
EU funding (EUR): 1609470.0
Participants: 1
Project status: SIGNED

I propose a novel membrane-like device that utilizes a ratchet mechanism to drive ions selectively up a concentration gradient. This device can serve as a building block for an efficient, ion selective separations technology. Ion selective separation with membrane-based processes may advance dramatically technologies for water treatment, resource extraction from sea water, ion specific sensors and many other applications. Moreover, since about 10-15% of the global energy consumption is used for chemical separations, a high efficiency, membrane-based ion separation processes can reduce greenhouse gas emissions significantly. However, membrane-based ion selective separation is a longstanding unmet challenge in science and engineering. Although conventional membrane-based separation is extremely efficient in unselective separation processes such as reverse osmosis water desalination, membrane-based processes showed limited success in ion specific separations. Furthermore, the need for a molecular level control of the membrane properties, limits the scalability of most of the membrane-based ion selective separation techniques that are currently being studied. Our proposed device, the ratchet-based ion pump, is driven with a ratchet mechanism which utilizes modulations of a spatially asymmetric electric field to induce a non-zero net ion flux up a concentration gradient. We will utilize a fundamental ratchet process in which the ratchet input signal drives particles with the same charge but different transport properties in opposite directions, to design highly selective, fit-to-purpose, and real-time controlled ion separation systems thereby bypassing the limitations faced by current technologies. In this research we will combine theory, simulation and experiment to improve our understanding of the ratchet mechanism, design and optimize ratchet based ion pumps, demonstrate ion selective ratchet-based separation systems, and set their thermodynamic performance limits

Keywords: ratchets,ion pumps,selective ion separation
Multimodal integration of olfactory and acoustic cues in mouse courtship communication (OLF-ACtion)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

The ability to select a suitable mating partner is one of the primary mechanisms under which evolution occurs. Animals have evolved species-specific communication strategies that influence mate choice. During courtship, males display a combination of multisensory sexual cues to attract females. Despite extensive work has been done in understanding the role of different sexual cues in female attraction, the neuronal mechanisms that regulate multisensory integration of courtship displays are completely unexplored. Male mice attract females by releasing sexual chemo-signals, contained in their urine and scent, and emitting ultrasound vocalizations (USVs). In inbred mice, females display an innate preference for USVs emitted by novel unfamiliar individuals. This preference emerges only if they are primed with male odours, indicating multisensory integration to be fundamental for mate selection. How the brain integrates multimodal information for USVs preference is completely unknown. I will capitalize on recent advances in optical imaging and neuroanatomy, including state-of–the art high throughput techniques, such as light-sheet whole-brain imaging and multi-site functional recordings, combined with natural instinctive behaviours and in vivo electrophysiology to: i) identify key brain areas involved in olfactory and acoustic integration for USVs preference during mate choice; ii) investigate how olfaction modulates USVs sensory processing in primary auditory areas. The proposed project will identify the neuronal basis of multisensory integration of courtship cues during mate choice. It will provide extensive training in neuroanatomy, behavioural assays and advanced optical approaches to study naturalistic behaviours and multimodal communication in rodents. The success of this proposal will have a major impact on my career development, enabling me to become an independent researcher and ultimately establish my own research group in the neuroethology field.

Keywords: olfaction,ultrasound vocalizations,mating behaviour,auditory areas,multisensory integration,multimodal communication
Efficient synthesis of high-performance millimeter-wave metasurfaces (MILLISURF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 230586.48
EU funding (EUR): 230586.48
Participants: 2
Project status: SIGNED

Fifth generation (5G) wireless networks have been introduced to enable significantly higher data rates and lower latency. Sixth generation (6G) wireless networks are also envisaged for even higher speed and capacity. In the context of 5G and 6G communications, the operation of wireless networks is shifted toward higher frequencies, as are millimeter-wave (mm-wave) frequencies. Metasurfaces present an appealing technological solution to realize low cost functional components of simple fabrication, especially in mm-wave frequencies, where component dimensions greatly decrease. Metasurfaces are the two-dimensional, planar extension of the well-established electromagnetic metamaterials and are capable of controlling and efficiently guiding propagating waves, by engineering the properties of individual subwavelength resonators. Although, the most appealing properties of metasurfaces arise in non-uniform configurations, the analysis and synthesis of such non-uniform metasurfaces is extremely challenging, especially as the size and complexity increase. Full-wave analysis of the entire structure, though highly accurate, it requires high computational resources and is extremely time-consuming. In some cases, it may even be inapplicable, due to the increased computational demand. MILLISURF aims at developing a computationally-efficient and robust semi-analytical framework to facilitate the analysis and synthesis of high-performance metasurfaces, suitable for mm-wave communications, combined with novel and highly-accurate fabrication techniques. MILLISURF will contribute to the field of wireless communications by advancing the existing technological solutions. The proposed research will be carried out at the Electrical and Computer Engineering Departments of Duke University, United States and Aristotle University of Thessaloniki, Greece.

Keywords: metasurfaces,metamaterials,millimeter wave,5g,semi analytical framework
ML-Driven SaaS Platform & In Silico Drug Repurposing for Treatment Resistance in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorders. (Psych-STRATA-Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Greece
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 2
Project status: SIGNED

The primary objective of the proposed project is to pioneer a revolution in the drug repurposing process for PSYCH STRATA targets by integrating groundbreaking methodologies such as text mining, network pharmacology, omics data analysis, and structure-based techniques. The ambition of the project lies in its endeavor to leverage the power of state-of-the-art scientific advancements to enhance the effectiveness and accuracy of drug repurposing. The inclusion of the widening partner, NovaMechanics, significantly bolsters the project's objectives and outcomes. The project is ambitious in its challenge to advance the state-of-the-art in drug repurposing. By using a data-driven methodology that leverages extensive existing resources and advanced computational strategies, it aims to swiftly and accurately identify potential compounds for repurposing, potentially leading to innovative therapeutic options for disorders such as SCZ, DP, and BPD. In line with the principles of transparent open science practices, the project ensures that research findings reach the broader scientific community. By fostering engagement with citizens, civil society, and end-users, the project promotes knowledge dissemination, stimulates collaborations, and potentially accelerates the development of new treatments. The project's methodology, underpinned by robust principles and cutting-edge technologies, incorporates a gender dimension by ensuring the inclusion of both male and female data in the omics data analysis. By highlighting the potential benefits of repurposed drugs, the project encourages active participation from citizens and civil society. In pursuit of excellence, the project integrates ambitious goals, innovative strategies, and an inclusive approach.

Keywords: drug re purposing,network pharmacology,omics data analysis,structure based techniques
sPatially and environmentAlly aCtuable nancoMposite hydrogels towArds Nervous system repair (PACMAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

This proposal aims to capitalize on my unique multi-disciplinary expertise in nanotechnology, tissue engineering, polymer/inorganic hybrids, and microsurgical techniques, while acquiring new proficiencies in the creation of breakable hybrid organosilica nanocapsules, mesoporous silica nanoparticles, and nanocomposite hydrogels. I am driven to tackle the unmet needs, opportunities, and challenges in the fields of nanocomposite hydrogel design and nervous system repair by combing my current expertise with these new proficiencies to innovate nanocomposite hydrogels that are environmentally and spatially actuable. Specifically, the goal of my proposal is to pioneer spatially distinct and environmentally responsive actuation of nanocomposite hydrogels in response to matrix metalloproteinase-9 (MMP-9) peptide cleavage, focusing on applications in peripheral nerve repair. In order to achieve this ambitious objective, I will develop MMP-9 degradable polyethylene glycol (PEG)/mesoporous silica nanoparticle composites and MMP-9 breakable organosilica nanocapsules through the incorporation of MMP-9 cleavable peptides into silica nanoparticle structures. MMP-9 can therefore be used to induce: 1) hydrogel degradation, 2) release of encapsulated therapeutics, and 3) capture of molecules by cleaved nanoparticle scavengers. This proposal details a highly interdisciplinary approach to create a plug-and-play nanocomposite hydrogel system to overcome obstacles needed to improve regeneration outcomes by combining neuroscience and microsurgical nerve repair with chemistry, drug delivery, biomaterials science, and tissue engineering. Finally, nanocomposite nerve guidance conduits will be tested in a peripheral nerve injury model to demonstrate in vivo MMP-9 actuation of these hydrogels.

Keywords: mesoporous silica,organosilica,matrix metalloproteinase,peripheral nerve repair