Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breaking into the brain- basement membranes and the perivascular niche (B3M)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2300451.0
EU funding (EUR): 2300451.0
Participants: 1
Project status: SIGNED

In neuroinflammation leukocytes reside for several days in the perivascular niche of cerebral blood vessels - defined by the basal surface of the endothelium, the endothelial basement membrane (BM) and an outer parenchymal BM with associated astrocyte endfeet (Fig. 1) - a poorly studied site but of utmost fundamental and clinical relevance. This site is also emerging as harbouring genetically distinct resident cell populations, the function of which are unclear. BMs define the perivascular niche and the sealed nature of this compartment in an unknown manner. B3M will explore the perivascular niche of cerebral vessels. Using our new dextran-hydrogel with tuneable adhesive, stiffness and degradability properties and cerebral endothelial cells derived from induced pluripotent stem cells (iPSC) we will recreate the subendothelial site; we will sequentially increase its complexity to reflect the in vivo spatial arrangement of cells and BMs, within the most correctly mimicked environmental properties, in a system that permits perfusion with immune cells and live imaging. Parallel ex vivo and synthetic approaches will further break down the complexity of this site into discrete steps and using multiscale imaging of new split-cre transgenic mice we will track, target and profile perivascular cells lacking BM receptors. Studies to date on leukocyte entry into the brain focus on endothelial properties or immune cell behaviour with little consideration of the 3D relationship between cellular and BM barriers and their functional interdependence. My unique knowledge on extracellular matrix structure/function of cerebral vessels and leukocyte migration into the brain, allows me to identify key elements of the perivascular niche and how they can be mimicked in vitro and targeted in vivo. B3M’s cross-disciplinary approach will decipher cellular and molecular events occurring after leukocyte penetration of the endothelium in the perivascular niche, shedding light on a black box.

Keywords: neuroinflammation,perivascular space,biomimetic models,basement membrane
Clinical portfolio strategy for regenerative muscle stem cell therapies (MyoPax)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

MyoPax is a women founded company with locations in Germany and in Denmark. Myopax uses a proprietary, patented, first-in-class stem cell technology to become the leading engineering platform for the treatment of skeletal muscle wasting disorders. In Europe alone, more than 20M people are affected by the devastating consequences of muscle wasting. Only palliative care is available. We developed a method to produce pure and highly regenerative muscle stem cell populations (PHSats, Primary Human Satellite cell-derived stem cells). Preclinically, PHSats potently build new muscle and refill the muscle stem cell pool (long-term effect). We are setting up three stem cell platforms for today’s unmet medical needs: 1. Satori: Original PhSats (patented in EU/2021, US/2022) to treat local muscle defects with a single injection. 2. Satgeno: Genetically corrected PHSats in genetic muscular dystrophies. A patent has been filed in 2022. Satori and Satgeno are clinical-trial-ready. First-patient-in is planned for Q3 2023. 3. Satuni: Muscle stem cells derived from induced pluripotent stem cell (iPSC) as a universal allogenic muscle stem cell product. We will deliver preclinical efficacy in 2024 for thus off-the-shelf product. With Women TechEU, we aim to further develop our clinical strategy including an international regulatory and IP strategy, detailed market analysis, and network building with KOL. The mentoring will help us to prepare the fundraising round, which includes company valuation strategies, preparation for due diligence and financial planning. The support will get MyoPax venture capital ready to leverage the technological potential and expand the clinical portfolio- giving back muscle power to those who need it.

Keywords: stem cell therapy,gene therapy,muscle regeneration,advanced therapy medicinal products,platform technology
Trust-by-Design – Strong Security Arguments for Symmetric Key Cryptography (SymTrust)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2485000.0
EU funding (EUR): 2485000.0
Participants: 1
Project status: SIGNED

Symmetric cryptographic primitives protect a large percentage of today's data, whether in transit or storage. This trend is going to increase even more in the future. Consequently, new domain-specific ciphers are needed with significant performance benefits for areas such as memory-encryption, multi-party computation, or crypto-currencies. Great progress has been made regarding their performance. Less progress has been made for security arguments that seek to proof their resilience against malignant attacks. Indeed, most of the security analysis we apply for symmetric ciphers is based on false assumptions and most attacks trying to break those ciphers are flawed. As a consequence, it takes several years to build the necessary trust in the security of any new symmetric cryptographic primitives to be deployed and used. In times of fast innovation cycles where emerging applications are in constant need for new tailored symmetric cryptographic solutions those slow design cycles of symmetric cryptographic primitives are prohibitive and have to be shortened. Within the project, I plan to enable stronger security arguments and tool-based bounds on key-recovery approaches which will accelerate the design process. This will open the path to a new design strategy of trustworthy by design ciphers and contribute to ready-to-use and highly-secure symmetric cryptography suitable to satisfy the needs of future applications. To this end, I will • analyze fundamental properties of symmetric cryptographic primitives especially related to their representation, • derive modular security arguments, • develop a software-assisted approach to optimize and verify the key-recovery part of attacks, • design an efficient cache-encryption algorithm to exemplify the potential of the new design framework. If successful, SymTrust will reshape the whole process of designing symmetric cryptographic ciphers to produce trustworthy by design primitives with the aim to shorten the time-to-deploy.

Keywords: symmetric cryptography,block ciphers,security analysis,key recovery attacks
The global ocean carbon cycle after peak emissions: Dynamics and process attribution in a seamless model framework from coastal shelves to the open ocean (OceanPeak)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1499953.75
EU funding (EUR): 1499953.75
Participants: 1
Project status: SIGNED

Atmospheric CO2 levels are 49% above preindustrial levels due to anthropogenic CO2 emissions. The ocean takes up ~25% of these emissions and thereby mitigates climate change. The Global Carbon Budget annually quantifies the atmospheric CO2 sources (emissions) and sinks (e.g. ocean uptake), and I coordinate its ocean CO2 sink estimate. The uncertainty of the ocean sink estimate is huge: The range of estimates is 2.5 times larger than the CO2 emissions of the EU27. It is unknown whether the ocean sink has grown or stagnated since 2016. And yet, we face an even larger challenge with the imminent transition to a new regime: In the past, the ocean sink was controlled by fast-growing atmospheric CO2. After peak emissions, atmospheric CO2 will grow slower, stagnate or even decrease. I hypothesize that the dynamics of the ocean carbon sink will then be fundamentally different and poorly quantified ocean ventilation processes will be even more important. Ventilation transports carbon to the deep ocean and is the ‘bottleneck’ of the ocean sink. OceanPeak will establish a game-changing forecasting capacity of the truly global ocean CO2 uptake in societally-relevant low-emission scenarios. OceanPeak will go beyond the ‘surface and open ocean’ estimate with a seamless transition to coastal shelves and from surface to depth. With a unique multi-resolution ocean carbon cycle model, I will: 1) develop a seamless coastal shelf to open ocean carbon cycle model and ground-truth ventilation processes based on newly-emerging observations to robustly quantify the ocean carbon sink to date 2) characterize the dynamics of the ocean carbon sink under regimes after peak emissions 3) attribute the evolution of the global ocean carbon sink to processes and quantify the time-scale of carbon sequestration. Quantification and understanding of the ocean sink from coastal to global scales will be paramount for an independent monitoring system of greenhouse gases as foreseen in the Paris Agreement.

Keywords: carbon cycle,coastal carbon cycle,emission verification
Co-creating a preparatory policy engagement programme for quality physical education (PEP-4-QPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

Quality physical education (PE) develops healthy, active, and engaged citizens who form the basis of sustainable development. However, quality PE provision is in decline globally. Suboptimal policies and policy implementation have been identified as key factors in that decline due to physical educators’ lack of preparation for policy engagement. In response, this fellowship will address the need to build PE stakeholders’ capacity to engage in policy efforts by: (a) identifying key facilitators, barriers, and content in the development of policy capacity; (b) translating complicated policy processes into practical policy lessons; and (c) developing a preparatory policy engagement programme for quality PE (PEP-4-QPE) that is evidence-based, internationally-applicable, and available as an Open Educational Resource. To do so, this research engages international PE stakeholders (i.e., teachers, teacher educators, policymakers, professional development providers, professional association directors) in co-design, co-creation, and co-assessment citizen science via the methods of a modified e-Delphi approach, participatory research, and case study. The potential scientific, economic, and societal impacts of the proposed research are aligned with contemporary European and global development agendas, including that of UNESCO, the European Commission, and the WHO, who have recently outlined that investment in quality PE is a ‘low-cost/high-impact action’ and that, at present, there is critical need to prioritize attention to, and action on, PE policy to improve quality provision. In addition to various advanced research and transferrable skills, this fellowship’s research and training components draw on and contribute to the disciplines of PE, education, and policy studies to enhance my multi-disciplinary and intersectoral career prospects and employability as a faculty member or policy leader in a European university or non-academic organization, respectively.

Keywords: quality physical education physical education policy policy preparation open educational resources participatory delphi
INCYPRO: A key technology to enable the broad application of proteins in diagnostics and therapeutics (INCYPROnext)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Poland
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 2
Project status: SIGNED

Proteins are not only one of life’s main building blocks, but also key tools for many industrial applications, ranging from drug discovery and diagnostics to chemical production processes. The main limitation of proteins is their low stability at non-physiological conditions, as they are commonly required in industrial, medical and biotechnological processes. Consequently, proteins often loose structural integrity and activity under relevant conditions. There are thousands of proteins with large potential, for instance in the context of protein targets related to diseases with high unmet need, point-of-care diagnostics and protein therapeutics. However, many cannot be utilized due to a lack of generally applicable technologies that allow straight-forward and meaningful protein stabilization. To address the challenges associated with protein stabilization, a versatile technology overcoming costly, time-consuming and uncertain trial-and-error approaches is required. The INCYPROnext project aims to provide a universal solution to the stabilization of proteins for biotechnological and biomedical applications. In the frame of the ERC PoC project, INCYPRO, we have developed a radically new technology for stabilizing proteins that has been validated in lab. Our innovation combines structural and molecular biology as well as chemistry to provide a highly effective and efficient technology for the stabilization of a broad range of proteins that are currently impossible to stabilize, delivering minimally modified proteins with a highly stabilized structure and retained functionality. This is an ideal value proposition to play a key role in a growing >170 B€ market, which can allow us to both offer B2B services to customers in the pharma, biotech, research and industrial processes segments, as well as to start our own internal drug discovery and development pipeline. In this EIC Transition project, we will validate the INCYPRO technology in a real operating environment (TRL5).
Reconstruction of global redox transitions based on an evolving Precambrian biological carbon pump (RETRO-PUMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1771359.0
EU funding (EUR): 1771359.0
Participants: 1
Project status: SIGNED

The history of life on Earth is intricately tied to the story of molecular oxygen (O2). Given that we breath O2 every day, the quest to understand its rise over billions of years is inherently tied to the fundamental question of our existence. However, critical turning points in our planet’s oxygenation, including the Great Oxidation Event, continue to escape our full comprehension. O2’s narrative involves a complex interplay of microbial life, biogeochemical processes, and geological factors, all intricately woven into the carbon cycle. Within the web of transformations, a black hole persists: the Biological Carbon Pump (BCP). The BCP is a crucial component of the Earth's carbon cycle, sequestering carbon from the atmosphere and transferring it to the ocean depths for burial over geological timescales. This burial process directly impacts global O2 levels, making the understanding of the ancient BCP crucial for unlocking Earth's oxygenation mysteries. However, deciphering how the ancient BCP functioned is challenging, as insights from the modern BCP, which is predominantly shaped by complex life forms, offer limited guidance when it comes to understanding its ancient counterpart, which operated in a world ruled by microorganisms. RETRO-PUMP sets out to unveil the secrets of the Precambrian BCP by reconstructing an ancient and evolving BCP with the goal of unravelling its regulation of O2 levels. It challenges the conventional view of a less efficient Precambrian BCP and explores uncharted relationships between microbial carbon cycling and major O2 transitions. This journey follows a simulated ocean pipeline, from the sunlit photic zone to the deep ocean, culminating in an integration of insights into a numerical framework. By tackling the drivers behind Earth’s oxygenation, RETRO-PUMP has substantial implications for understanding how the interplay of biological and geological factors ultimately paved the way for the rise of complex life as we know it today.

Keywords: precambrian,photosynthesis,biological carbon pump,microbial ecology,microbial physiology,biogeochemistry,geomicrobiology,model,molecular mechanisms,marine snow,global burial fluxes,atmospheric oxygen,cyanobacteria,photoferrotrophy,great oxidation event,banded iron formations,microenvironments
High-Entropy MXene Inks for Light-Induced Sintering of Flexible Zn-Air Batteries (FlexZAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

The FlexZAB proposal introduces an innovative approach to producing a new generation of printed flexible Zn-air batteries (ZABs), addressing key challenges such as sluggish oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics and high overpotential in traditional ZABs, while preserving the integrity of the support structure without traditional high-temperature sintering during manufacturing. The central component of this approach in FlexZAB is the synthesis and use of high-entropy MXenes (HEMXs), which play a pivotal role in both the fabrication process and the improved performance of the ZAB. MXenes, a family of two-dimensional (2D) carbides and nitrides of transition metals, are highly regarded for their flexibility, superior electrical conductivity, and partially metallic properties. Their 2D morphology makes them ideal for flexible applications, and they exhibit plasmonic effects under light irradiation, akin to Au and Ag. Incorporating multiple transition metals at the M site in HEMXs introduces a nearly infinite range of tunable compositions and properties. This leads to a quasi-continuous density of electronic surface states, promoting complex and reversible catalytic reactions such as ORR and OER. During flexible ZAB fabrication process of FlexZAB, the plasmonic properties of HEMXs will facilitate light-triggered sintering during manufacturing. The flexibility and interconnect of HEMXs serve as binders, enabling the production of additive-free inks and cathodes through aerosol direct-write printing. In battery operation, HEMXs boost performance by enhancing charge transport through high electrical conductivity. Additionally, their compositional versatility and abundant surface adsorption/reaction sites catalytically accelerate ORR and OER, resulting in more efficient battery performance.

Keywords: mxene,high entropy,flexible electronics printing technology light sintering plasmonic effect zn air battery catalysis
Xtend U – An Amputee solution for a life without pain, blisters and infections (XTEND U)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2351596.25
EU funding (EUR): 1646117.0
Participants: 1
Project status: SIGNED

Xtend U is a prosthetic liner developed to help ventilate the stump while fulfilling the primary role of a liner. Unlike traditional liners, it is made of 3 layers. The first layer is a compression sock in direct contact with the skin. It is made of an ultra-breathable textile and has friction increasing dots that further support the suspension to the stump. The second layer is a washable super-absorbent material that can absorb up to 1000% of its weight in water without significant volume change. Finally, the third layer allows for securing the liner to the prosthetic, protects the inner layers and helps transmit loads from the prosthetic. This combination of materials enables reducing by half the relative humidity around the stump. This will make a massive difference for users that will get a cooler feeling and reduced risk of chafing, blisters, sores and infections. Xtend U will provide crucial comfort allowing prosthetic users to wear their prosthetics for extended periods of time.

Keywords: prosthetics,absorption,perspiration,textiles,smart textiles,biomechanic