Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic and reconfigurable data centre networks with modular optical subsystems (DYNAMOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Finland,United Kingdom,France,Germany,Czechia,Ireland,Italy,Switzerland
Call: Advanced optical communication components (Photonics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-08-01
End date: 2026-07-31
Duration (months): 48.0
Total project cost (EUR): 6024476.25
EU funding (EUR): 4663334.0
Participants: 10
Project status: SIGNED

DYNAMOS develops fast (1 ns) and widely tunable (>110 nm) lasers, energy-efficient (~ fJ/bit), broadband (100 GHz) electro-optic modulators, and high-speed (1 ns) broadcast-and-select packet switches as photonic integrated circuits (PICs). DYNAMOS meets the expected outcome objectives and call scope by proposing the development of low energy (few pJ/bit) PICs, which are integrated into modular and scalable subsystems, and subsequently utilized to demonstrate novel data centre networks with highly deterministic sub-microsecond latency to enable maximum congestion reduction, full bisection bandwidth (lower congestion) and guaranteed quality of service while reducing cost per Gbps. The proposed network offers optical circuit switched reconfiguration and guaranteed (contention-less) full-bisection bandwidth, allowing any computational node to communicate to any other node at full-capacity. DYNAMOS builds on recent developments in III-V optoelectronics, thick silicon-on-insulator waveguide technology, and silicon organic hybrid (SOH) modulators. It co-develops the entire ecosystem of transceivers, switches and networks to boost overall performance and to reducing the total cost of data exchange, instead of focusing on the improvement of individual optical links or interfaces. The objectives of DYNAMOS perfectly match the major photonics research & innovations challenges defined in the Photonics21 Multiannual Strategic Roadmap 2021-2027.

Keywords: data center,network architecture,switch,tunable laser,electro optic modulator,photonic integrated circuit,pic,hybrid packaging,soi,silicon organic hybrid,sin,inp,
Structural Health Assessment of Bridges during and after FLOOD events (FLOOD-SHAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The project "Structural Health Assessment of Bridges during and after FLOOD events" (FLOOD-SHAB) aims to investigate the structural behaviour of critical infrastructures such as bridges, focusing on the studying and assessing the structural response of bridges during and after flood events. The main objective is to improve the understanding of bridge structural behaviour under various health conditions and enhance the capacity to detect structural damage caused by component failure or foundation scouring. Climate changes increasingly impact our life. It has become less predictable. Droughts, floods, and new temperature records are becoming more common worldwide, including in Europe. The rising global temperature intensifies the water cycle, which increases wet and dry extremes and affects the critical infrastructure essential for the functioning of a society and economy. Due to their significance, bridges need protection from potential hazards, including natural disasters and ageing. The increased water levels result in the additional force from fast-moving water, which can lead to structural damage, and scouring of bridge foundations. Regular inspections, continuous structural health monitoring (especially during flood events), and maintenance programs are vital to ensure bridges' structural integrity and safety. The bridge monitoring research focuses around addressing the challenges of data capture and data interpretation. In the aspect of floodings, there is a lack of knowledge about correct measuring techniques and data interpretation for these instantaneous phenomena. By comprehensive data collection of bridges’ structural behaviour on-site for the selected local case studies (at least 2 bridges) and further rigorous analysis, interpretation, and wide numerical simulations, the patterns and trends in the bridges’ structural behaviour, especially during and after flood events, and feature thresholds will be defined and established.

Keywords: structural health monitoring,bridges behaviour during flooding,digital twin models,data driven analysis,innovative monitoring techniques
Characterization of the role of Sac1 in the spatiotemporally controlled interplay between PI4P and cholesterol homeostasis (PIP-AID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2025-07-31
Duration (months): 33.0
Total project cost (EUR): 218651.92
EU funding (EUR): 218651.92
Participants: 1
Project status: SIGNED

Lipids are essential components of cell membranes. Every organelle membrane is constituted of a unique composition of different lipid species. This distinctive lipid distribution along organelle membranes is important to maintain the identity and functions of the different organelles. In this research project, I aim to understand how the lipid species phosphatidylinositol-4-phosphate (PI4P) is regulated and how this affects lipid homeostasis and cellular functioning. The PI4P distribution is important for intracellular signalling, lipid and protein trafficking. Alterations in PI4P levels may contribute to the progression of other neurodegenerative disorders, e.g. Alzheimer's disease. In this project, I will study the PI4P phosphatase Sac1. Sac1 consumes PI4P in the endoplasmic reticulum or Golgi apparatus. This locally lowers PI4P levels, therefore maintaining the asymmetric distribution of PI4P in the cell. The PI4P gradient is important for the transport of lipids and proteins. In cell models, Sac1 knockdown or knockout severely compromises cell viability, whereas Sac1 knockout mouse or drosophila are embryonically lethal. This highlights the importance of Sac1, however, making it difficult to examine the physiological functions of Sac1. In this project, I will use an auxin-inducible degradation (AID) system to induce the degradation of Sac1 within one hour. This allows me to assess the acute effects of Sac1 depletion. Using this model, I will address the following key objectives: 1) Examine the role of Sac1 in lipid homeostasis. 2) Investigate the regulatory mechanism of Sac1 in Golgi morphology and kinetics, and 3) Characterize a inducible degradation system in zebrafish. By employing the AID system in a zebrafish model, I aim to provide a new means to study the role of Sac1 in development. Taken together, this project will contribute to deeper insights into the regulatory function of Sac1 in lipid homeostasis and selective protein secretion.

Keywords: non vesicular lipid transfer,membrane contact sites,cholesterol metabolism,phosphoinositide homeostasis,pi4p,sac1
BLUE OCEANS STRATEGY FOR VALUE CREATION (BEAGLE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Spain,Czechia,Sweden,Ireland,France,Bulgaria,Poland
Call: Experimentation and exchange of good practices for value creation (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1002016.25
EU funding (EUR): 1002015.75
Participants: 9
Project status: SIGNED

BEAGLE proposes an innovative methodology for value creation from the uptake of the research results applying the Blue Ocean strategy. It explores new market niches by fostering sustainable value chains in untapped markets, while promoting disruptive synergies and innovation. This will be achieved through constructing a BEAGLE network of 3 universities, 1 technology centre, 1 innovating communities’ manager and 4 industry clusters with a work plan which will be implemented by the active participation of 240 professionals from 7 European countries, both innovators (from industry) and researchers (academia and tech centre) through the application to an ad hoc open call. Multiple disciplines, sectors and geographic areas are called to connect and interact in this A-I BEAGLE community (mainly those of the participating entities). By the end of the project the goal is to unveil 20 new market niches, the Blue Oceans, and to co-create 20 innovation proposals with specific roadmaps. To facilitate the co-creation experiment 12 Mixed Teams will be set, expert researchers and TTOs officers form the academia and the technology centre will merge with the cluster managers and their representatives from the industry clusters. Those actors will lead, manage, and supervise the whole work plan starting by the recruitment of professionals from their own institutions (the mentioned open call), to actively join BEAGLE as participants of the proposed innovation funnel. Three phases are planned: I) discovering opportunities through co-creation activities (workshops, survey, interviews, video-factsheets, system innovation approaches); II) co-creating the innovation proposals; and III) consolidating 20 new innovative market niches to attract investment. A dedicated marketplace linked to the F6S platform (4.4 million members) will facilitate the implementation of the project and its further sharing of results and lessons learned, will ensure its continuity after the project’s funding period.

Keywords: blue oceans,disruptive innovation,knowledge valorisation,academia industry collaboration,market creation strategy,added value
Functional UltraSound Integrated with Optical imaging in Neonates (FUSION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-19
End date: 2027-08-18
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Premature birth disrupts the crucial perinatal period, significantly increasing the risk of lifelong neurodevelopmental disabilities (NDDs) such as cerebral palsy, attention deficit, and autism. Current brain imaging techniques, like cranial ultrasound and MRI fail to characterize subtle brain injuries and to predict long-term neurodevelopmental outcomes. Therefore, NDDs are often diagnosed years after birth, missing the crucial window for early intervention. Functional connectivity (FC), which quantifies how brain regions connect, holds promise as an early biomarker for neurodevelopmental outcomes as abnormal FC patterns are likely to precede later behavioural alterations. However, existing imaging methods, such as EEG and fMRI, are either limited in resolution or impractical for routine neonatal use. The FUSION project aims to address this gap by developing a novel neuroimaging device that monitors FC in the neonatal brain. FUSION proposes a ground-breaking solution by integrating High-Density Diffuse Optical Tomography (HD-DOT) and functional ultrasound (fUS) imaging into a single, high-resolution, bedside device. Both technologies have been used for proof-of-concept studies for neonatal imaging in the last few years, but have their own limitations: HD-DOT can only evaluate FC in cortical areas, missing deep structures, whereas fUS has a restricted access to cortical areas but can image deep structures. The project aims first to create and validate this dual-modality headset for use in neonates, then to define the interaction between HD-DOT and fUS signals and finally to assess whole-brain FC during different sleep states in both healthy term and preterm infants to demonstrate its capacity to give new biomarkers of brain maturation and sleep integrity, known to influence the outcome. By advancing neonatal neuroimaging, FUSION will go beyond the state of the art, offering the first cost-effective, high-resolution, cot-side device for whole-brain FC assessment.

Keywords: functional ultrasound imaging functional near infrared spectroscopy neonatal brain injury prematurity neurodevelopment
Automata, Dynamics and Actions (ADA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2419896.0
EU funding (EUR): 2419896.0
Participants: 1
Project status: CLOSED

This project lies at the nexus of complex and symbolic dynamics, group theory, decision problems and computation. It aims to solve major problems in each of these fields by means of automatic actions and relations. Finite state automata, pervasive in theoretical computer science, will serve to define self-similar mathematical objects, and produce efficient algorithms to manipulate them. — I will explore a novel notion of automatically acting group, encompassing the previously unrelated notions of automatic groups, automata groups and substitutive shifts. Geometric group theory propounds the vision of groups as geometric objects. A basic notion is volume growth, and Milnor's still open “gap problem” asks for its possible range. — In this proposal, I will give candidates of groups with very slow superpolynomial growth, defined by their automatic action on dynamical systems, and a proof strategy. A celebrated open problem by Gromov asks whether all groups are “sofic”. This property has too many valuable consequences to always be true, yet there is no known non-example! — I will present a strategy of producing non-sofic groups closely associated to automata. Rational maps on the Riemann sphere provide a rich supply of dynamical systems. A fundamental goal is to give a combinatorial description of the dynamics across families of maps, constructing models of parameter space. — I will encode the maps via automatic actions, and study relations between automata to produce such models. I aim to achieve a full topological description (including the long-open connectedness problem) of Milnor's “slices” of quadratic maps. This project will tackle these fundamental questions from group theory and dynamics, and develop presently unexplored interactions between them, through a unified use of automata. It will prove decidability of certain algorithmic problems such as Dehn's and Tarski's, and construct efficient tools to further our exploration of these mathematical universes.

Keywords: group theory decision problems symbolic dynamics complex dynamics
PROposing Action to ConTrol and Impede betacoronaVirus Emergencies (PROACTIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

The COVID-19 pandemic caught the world unprepared. Vaccines and monoclonal antibodies (mAbs), developed in record time, mitigated the health and economic damages, however our reaction has always been one step behind the virus evolution, and emerging variants repeatedly escaped our interventions. The omicron variant escaped humoral immunity generated by most vaccines and mAbs by mutating immunodominant epitopes. The extremely potent mAb developed by our laboratory also lost potency against omicron. Here we propose to develop vaccines and monoclonals neutralizing existing and future variants of SARS-CoV-2 and other coronaviruses, by targeting immunologically subdominant regions which are less susceptible to antigenic variation. We will isolate mAbs from individuals who had infection and multiple vaccinations, whose repertoire is enriched in B cells encoding broadly neutralizing antibodies, to build a map of the broadly shared epitopes. Structural prediction and clustering of the immune repertoire through deep neural networks will be used to improve the breadth of coverage of the mAbs. The Monte Carlo-based sequence design of Rosetta and free energy perturbation calculations will be used to in-silico “design protein-binding proteins” and identify newly designed immunogens which can be loaded on nanoparticles and used as vaccines. This approach will provide broadly protective mAbs and vaccines proactively designed to neutralize all variants of SARS-CoV-2 and new coronaviruses that are very likely to jump from animals to humans in the future. If successful, the approach to map subdominant epitopes and use of genomic and structural information to design mAbs and vaccines targeting subdominant, broadly conserved epitopes, will pave the way to approach other pathogens with high antigenic variability such as influenza and HIV viruses, Plasmodium spp. and antibiotic resistant bacteria. This will strongly increase European competitiveness in fighting infections.

Keywords: monoclonal antibodies,sars cov 2,coronavirus,pandemic preparedness,global health,artificial intelligence
The project aims to close the biomass supplying loop that in turn develops a circular economy and biogas production, decreases methane emissions and promotes sustainable farming. (REUSING PLATFORM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Slovakia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

EHOSS Reusing Platform aims to revolutionize waste management by converting animal manure into valuable biomass for biogas production, thereby addressing sustainability and energy challenges. The platform's key objectives are to develop the use of biomass, improve waste disposal efficiency, reduce greenhouse gas emissions, and support the circular economy. By transforming manure into feedstock for biogas plants, the project offers farms a new income stream while contributing to renewable energy production. To achieve these goals, EHOSS has developed a decentralized infrastructure that integrates farms and biogas plants into a single network. Manure is processed on-site using specialized equipment, ensuring high-quality feedstock. It also includes storage solutions that minimize environmental impact and an enhanced logistics system to streamline transportation and reduce costs. Two pilot projects are launching in Germany and Slovakia. The Reusing Platform aligns directly with the EIC Accelerator's work program by fostering innovation in the renewable energy sector, promoting sustainable farming practices, and reducing Europe's reliance on fossil fuels. Its breakthrough potential lies in its comprehensive approach that covers processing, storage and logistics. It is also planned to be scaled to other types of biomass. This project supports the 7th, 9th, and 13th UN Sustainable Development Goals and key EU policies such as the European Green Deal and the Circular Economy Action Plan, making it a vital solution in the transition to clean energy and sustainable agriculture.

Keywords: biomass manure reusing recycling disposal methane emissions fertilisers feedstock horse bovine cattle farms stables organic waste bioenergy biogas biomethane sustainable circular economy
Hydraulic compression for high capacity hydrogen refuelling station Demonstration (H2REF-DEMO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Italy,Germany
Call: Development of novel or hybrid concepts for reliable, high capacity and energy-efficient H2 compression systems at real-world scale (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 5786712.5
EU funding (EUR): 4617384.88
Participants: 7
Project status: SIGNED

H2REF-DEMO aims to further develop and scale up by a factor of 5 the innovative compression concept developed in H2REF, in order to address large vehicle refuelling applications requiring hydrogen to be dispensed at rates of hundreds of kg/h, such as bus fleet refuelling every evening at the bus depot, truck refuelling, and train refuelling. Thanks to demonstrating the process during one year for commercial 35 MPa refuelling of trucks, the project will bring to TRL7 the disruptive compression technology previously developed in the H2REF project and already validated for 70 MPa refuelling of light duty vehicles. Along with capacity scale-up, H2REF DEMO will focus on process optimisation, cost reduction and further durability testing, Full optimisation will be achieved by first developing a digital twin of the scaled-up process. Use of accumulators with shells in hoop wrapped steel (Type II), a suitable technology for 35 MPa refuelling, will allow to optimise costs. A thorough accelerated testing approach involving at least 500 hours of continuous operation, will allow to verify durability of the accumulators and the compression stages over the full range of operating conditions. The demonstrated system is expected to provide a peak dispensing capacity of 150 kg/h, amounting to 1200 kg/d with 8 hours of daily operation, with a targeted cost of 1200 €/(kg/d). The process is expected to reduce electricity consumption to 3.5 kWh/kg of dispensed hydrogen, from production on site at 2 MPa to vehicle tank at 42 MPa. The knowledge gained will allow subsequent development to focus on commercial product development for short term commercial deployment. A multi-disciplinary team, composed of 4 industrial companies and 3 RTOs, combining expertise in hydraulic power supply, in bladder accumulator, in process simulation, modelling process digital twins, in H2 refuelling and distribution stations is gathered in the consortium to reach the targeted KPIs of H2REF-DEMO.

Keywords: hydrogen refueling station,compresssion,bladder accumulators