Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimised Real-time Yard and Network Management (OPTIYARD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Italy,Germany,Italy,Belgium,Slovakia,France,France,Czechia,Czechia,United Kingdom,United Kingdom
Call: Real-time yard and network management (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 1499900.0
EU funding (EUR): 1499900.0
Participants: 14
Project status: CLOSED

The Commission’s 2011 White Paper states that by 2050, rail should substantially expand its modal share over medium and long distances. This is consistent with the Policy goals of expanding rail capacity, both cited in the Horizon 2020 and Shift2Rail (S2R) calls. Considering the ambitious Horizon 2020 Key Performance Indicator (KPI) calling for a surge in the utilisation of capacity within a range 70-90%, yards, hubs and terminals play a key role in facilitating this step-change by contributing to a competitive, reliable and safe freight transport. To meet the needs of S2R and Horizon 2020, OptiYard will design decision support tool for yard managers that will help them to optimise processes and manage their yards more efficiently. It will do this in real-time, with interaction with relevant network. The processes must be performed in real-time, to guarantee on-time delivery and operational efficiency, in particular, for single wagon transport. OptiYard addresses critical operational points of the transport chain (both rail marshalling yards or as transfer points to other modes) to improve capacity and reliability. OptiYard will facilitate real-time interaction between yard and relevant network IT systems that allow for software based planning and ultimately optimisation of single wagonload and blocktrain operational processes. Building on the current state of the art and practice, the ambition of OptiYard is to provide a fully functional software module where real-time yard management, interaction with the network and ad-hoc timetable planning will be simulated in real-time. The optimization module and algorithms will be proven for large and complex freight transport networks, and integrate well with IP5 activities towards automation, e.g. intelligent assets and automated shunting and mainline operations.

Keywords: optimisation,yard operations,algorithms,simulation,yard management,marshalling,process optimisation,td5 2
WHat next? an Integrated PLanetary Atmosphere Simulator: from Habitable worlds to Hot jupiters (WHIPLASH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France,France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1480421.0
EU funding (EUR): 1480421.0
Participants: 2
Project status: CLOSED

Thousands of exoplanets have now been found. In the next decade, the grand challenge is to characterize their atmospheres. This is the only way to unravel the origin of the wild, unexpected diversity we have uncovered. For this task, there are several planned missions—JWST being our next best opportunity. However, to be ready for the analysis and interpretation of such high-precision observations, we need new-generation tools fit to address the multiple challenges they will raise. Indeed, until now, most atmospheric characterization observations—e.g. transit/eclipse spectroscopy—are analyzed with spherically symmetric, steady state 1D models that cannot accurately represent the very anisotropic atmospheres of most transiting exoplanets. This issue is worsened by the ubiquity of clouds, whose inhomogeneous spatial distribution—patchiness—prevents any satisfactory treatment in 1D. In this project, we will develop a new framework to constrain the physics and composition of exo-atmospheres that will allow us to overcome these difficulties when analyzing and interpreting observations. This will be done by exploiting a new 3D planetary atmosphere simulator that integrates a global climate model and a 3D Monte Carlo radiative transfer code to generate observables. Using such an innovative approach, this ERC project will thus answer the following fundamental questions: - What are the necessary conditions to sustain liquid water on terrestrial exoplanets? How can we infer observationally whether an atmosphere meeting these requirements is actually present? - Can clouds explain the puzzling features of observed hot, gaseous exoplanets? What can these observations tell us on the dynamical and microphysical properties of clouds inside these atmospheres? If we want theory to keep pace with the quality of future data, such a project is the necessary counterpart to the huge ongoing observational effort made by the community.

Keywords: exoplanets,planetary atmospheres,observational characterization,jwst,data analysis,habitability
iFACT - Iodine Fed Advanced Cusp field Thruster (iFACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Belgium,Bulgaria,France,United Kingdom
Call: SRC – In-Space electrical propulsion and station keeping (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2022-06-30
Duration (months): 30.0
Total project cost (EUR): 1999595.0
EU funding (EUR): 1999595.0
Participants: 8
Project status: SIGNED

Since several years, the industrialisation of the satellite market has been accelerated. In particular, the market for telecom satellites has changed significantly, because of several new players and numerous plans for satellite constellations, such as OneWeb or Starlink. In order to increase competitiveness and to disrupt the electric propulsion market, we are proposing the development of the iodine Fed Advanced Cusp field Thruster (iFACT). iFACT consists of an Advanced Cusp Field Thruster (ACFT), a simple PPU, a thermionic Emitter, a novel propellant feeding architecture, which is optimised for iodine. The ACFT has been invented by Airbus in 2017. Due to its simplicity, paired with efficiency, the fact that it is easy to ignite and its excellent performance data with iodine, it is tailored as key element for an extremely simple, efficient and low cost Electric Propulsion Subsystem (EPS). The baseline thruster (300 W input power) can be used with a simple thermionic cathode. The simple operation of the ACFT enables a reduced (wrt. number of parts and control circuits) but efficient PPU. This components are paired with an unique iodine feeding architecture which is capable to disrupt the electric propulsion market. Based on this, the proposal will focus on: - Iodine as disruptive propellant for electric thruster, - maturation of the Advanced Cusp Field Thruster (ACFT) as disruptive thruster principle, in three different power classes, - development of an novel, disruptive, extremly simplified low cost Power Processing Unit (PPU), - use of calcium aluminate (C12A7) as disruptive, low-work function emitter material for cathodes, - development of an European Iodine compatible long firing test facility.

Keywords: disruptive thruster,iodine,testing,simple ppu,c12a7,low cost eps
Identification and functional validation of novel enhancer sequences involved in pituitary gland development and pathology (Pituitary enhancers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-16
End date: 2022-03-15
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

There is a fundamental gap in understanding how the GPR101 gene regulates human growth in physiological and pathological conditions. Children’s growth is remarkably clinical relevant and is an important indicator of their health and general well-being. The specific objective of this proposal is to identify the molecular mechanisms underlying GPR101 overexpression in the pituitary tumors of children with GPR101 duplications causing X-linked acrogigantism (X-LAG). My central hypothesis is that GPR101 duplications disrupt the structure of the local chromatin, leading to the creation of a new chromatin domain where de novo enhancer-promoter interactions take place, causing abnormal GPR101 expression. This hypothesis will be tested by pursuing three specific aims: 1. Elucidate the transcriptional regulation of GPR101 in normal and pathological conditions 2. Identify and functionally characterize novel pituitary-specific enhancer sequences 3. Investigate these regulatory sequences in patients with different pituitary pathologies. To achieve aim 1) I will perform an in vitro functional characterization of GPR101 promoter: promoter activity will be studied by luciferase-based reporter assays, by conducting a methylation analysis, and by determining its accessibility to transcription factors. To achieve aim 2) I will validate my preliminary results showing the formation of a novel chromatin domain by 4C-Seq. Four putative enhancer sequences located within the duplicated GPR10 region and identified in silico will be functionally evaluated in vitro to establish their impact on transcriptional activity. To identify novel pituitary-specific enhancers, a whole-genome profile of enhancer-specific histone marks will be performed in normal and tumoral pituitary cells by ChIP-Seq. To achieve aim 3) I will screen patients with different pituitary disorders for mutations (Sanger sequencing) and structural variations (CNV assays) in the functionally-verified enhancers.

Keywords: pituitary gigantism
Light-Induced Spin Switch using Dynamic Organic Species (LIDOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The LIDOS project uses in-silico approaches to design nanometer sized photomagnetic (PM) switches. Switches of this kind find use in myriad technological devices, primarily because of their ability to alter their magnetic response upon light irradiation. This project follows an underexplored, yet promising, strategy to obtain new PM switches with enhanced properties. Specifically, dyads (i.e. two-component molecules) will be designed that combine a photoswitch and a magnetic moiety hosting unpaired electrons. Despite attempts to design PM switches employing both transition metals and purely-organic radicals as magnetic units, significant advances in magnetic response remain elusive. This project aims to rationally develop efficient PM switches featuring pronounced changes in magnetic response at room temperature, using purely-organic components. Azobenzene and Diarylethene derivatives will serve as photoswitches, whose primary mission is undergoing a reversible structural change that modulates the magnetic interaction between the radical moieties of adjacent dyads. Thus, the design principles are based on supramolecular choreography. DTA- and Verdazyl- molecules will be targeted as radicals, and will be affixed to photoswitches via linker groups. In the first step, computational screening will be used to explore the best component combinations leading to a set of potential PM switches. In the second step, candidates will be further tuned to optimize their optical properties. The overarching goal is the identification of a reversible PM switch triggered by visible light. LIDOS lies at the intersection of photochemistry, molecular magnetism, computational chemistry, and physical organic chemistry. It combines well-established DFT-based approaches, computational methods to describe and understand non-covalent interactions recently developed at the host institution (EPFL), and state-of-the-art molecular dynamics techniques to study the photochemical process.

Keywords: molecular magnetism,photochemistry
Sensitivity of human tumors to T cell attack (SENSIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-12-01
End date: 2022-11-30
Duration (months): 60.0
Total project cost (EUR): 2405625.0
EU funding (EUR): 2405625.0
Participants: 1
Project status: CLOSED

The goal of this project is to describe the tumor cell-intrinsic mechanisms that determine whether ‘foreign’ human cancers are sensitive or resistant to the tumor-specific T cell response they induce. In this effort, I will focus on 3 linked questions: 1). While we know that T cell activity in human tumors can lead to cancer regression, we do not know whether such regression is mostly mediated by T cell secreted cytokines or granzyme mediated lysis. We will address this fundamental question by analysis of the sensitivity of human tumors to defined T cell effector mechanisms, and subsequent correlation to patient outcome upon immunotherapeutic intervention. 2). We will complement this analysis of baseline tumor sensitivity with a systematic analysis of acquired immunotherapy resistance in patients treated with T cell checkpoint blockade. Through comparative genomic and immunological analysis of pre- and post-therapy tumors we will determine the clinical importance of tumor cell-intrinsic mechanisms of acquired resistance, and will identify novel mechanisms of such resistance. 3). In addition to these unbiased analyses of tumor resistance, we will focus on one resistance pathway of particular interest: Expression of PD-L1 has emerged as the key immune inhibitory pathway in human cancers, but our understanding of PD-L1 protein regulation is highly limited. We have recently identified PD-L1M1 as a molecular partner of PD-L1 that controls its cell surface abundance. A central goal of this application is to understand the function of the PD-L1 – PD-L1M1 complex, and whether PD-L1M1 can be used as a target for immunotherapeutic interventions. Collectively, this project exploits three approaches to reach one goal: fundamental insight into the mechanisms that control the sensitivity of human cancers to T cell attack. In addition to the mechanistic insights we will obtain, this project may yield novel strategies to enhance tumor-specific T cell activity in patients.

Keywords: tumor immunology,t cell recognition,cancer immunotherapy
5th Generation connected and automated mobility cross-border EU trials (5G-ROUTES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Estonia,Germany,Spain,Italy,Spain,Spain,Cyprus,Finland,Greece,Greece,Greece,Latvia,France,France
Call: 5G PPP – 5G for Connected and Automated Mobility (CAM) (H2020-ICT-2019-3, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 11354739.99
EU funding (EUR): 9177397.879999999
Participants: 23
Project status: SIGNED

5G-ROUTES is a 5G-PPP Phase 3 project whose aim is to validate through robust evidence the latest 5G features and 3GPP specifications (R.16 & R.17) of CAM under realistic conditions. In particular, it will conduct advanced large-scale field trials of most representative CAM applications to demonstrate seamless functionality across a prominent 5G cross-border corridor (Via Baltica-North), traversing Latvia, Estonia and Finland. This will help to boost confidence and accelerate the deployment of 5G-based interoperable CAM ecosystems and services throughout Europe. It also aims at validating 5G as a true enabler of innovative CAM services that cannot be realised by today’s technology. Specifically, 5G-ROUTES will provide: (a) validation of >150 network, business and service-level KPIs for 13 diverse CAM use cases that require 5G performance capabilities, covering several V2X scenarios in automated cooperative, awareness and sensing driving. 5G-ROUTES also focuses on uninterrupted infotainment passenger services on the go and multimodal services in the context of complete connectivity-enabled ecosystems around passengers and cargo over 3 different modes of transport (vehicles, rails and maritime); (b) innovative AI-based technological enablers for facilitating the execution of the field trials. Several scenarios will be considered for each use case covering cross-border, cross-telecom operators, cross telco-vendors, integrated cross terrestrial-satellite and cross-transport-mode settings. These will be incrementally validated, starting from lab trials, followed by localised large-scale trials at strategic cross-border locations (Valga city, Tallinn & Gulf of Finland) and finally in larger-scale trials covering significant portions of transport routes along the selected corridor. Our 22-partner consortium is driven by industry heavyweights and renowned organisations the majority of which participate in 30 out of 63 5G-PPP projects and in several 5G-PPP Working Groups.

Keywords: 5g corridor,continuous and automated mobility,large scale cross border cam field trials,c v2x,frmcs,artificial intelligence
Preventing Recalcitrant Organic Mobile Industrial chemicalS for Circular Economy in the Soil-sediment-water system (PROMISCES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Spain,Italy,Germany,Germany,Germany,Germany,Spain,Bulgaria,Hungary,Poland,France,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands
Call: Innovative, systemic zero-pollution solutions to protect health, environment and natural resources from persistent and mobile chemicals (H2020-LC-GD-2020-3, 2020)
Start date: 2021-11-01
End date: 2025-04-30
Duration (months): 42.0
Total project cost (EUR): 11995413.75
EU funding (EUR): 11995413.75
Participants: 29
Project status: SIGNED

PROMISCES will identify how industrial pollution prevents the deployment of the circular economy (CE) in the EU and which strategies help overcome key bottlenecks to deliver the ambitions of the European Green Deal and Circular Economy Action Plan. PROMISCES considers specific CE routes including (i) semi-closed water cycles for drinking water supply at urban and catchment scale; (ii) wastewater reuse for irrigation in agriculture; (iii) nutrient recovery from sewage sludge; (iv) material recovery from dredged sediment and (v) land remediation for safe reuse in urban areas. To reach its goals, PROMISCES will: - Develop new analytical methods and toxicological tools to provide data on persistent, mobile (PM) substances (i.e. PFAS and other industrial chemicals) in complex environmental matrices. - Explore sources and environmental pathways of PM substances released from (i) soil; (ii) sediment; (iii) landfills; (iv) wastewater treatment plants and via (v) urban runoff into relevant environmental compartments (soil, sediment, surface water, groundwater). - Assess fate and transport pathways within the different CE routes and evaluate the impacts of corrective measures. - Improve the assessment and management of human health risks from drinking water and agricultural products. - Develop and demonstrate cost-efficient and sustainable technologies for the removal of PM substances from different media. - Translate PROMISCES results into guidance for efficient and feasible management of PM substances and recommendations for the implementation of relevant EU policy strategies and directives. - Integrate the results into a decision support framework which considers resource recovery and water reuse and supports chemical management decisions with regards to i) stakeholders and societal demands; ii) PM chemical properties iii) technical solutions to prevent, mitigate and remediate industrial pollution and iv) the whole life cycle of current and future chemicals.

Keywords: persistent and mobile substance,water,pfas,wastewater,circular economy,resource recovery,risk management,toxicological tools,water reuse,zero pollution,policy support,human health
Efficient Co-Electrolyser for Efficient Renewable Energy Storage - ECo (ECo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Germany,Germany,Spain,Switzerland,Belgium,France,France,Denmark
Call: Development of co-electrolysis using CO2 and water (H2020-JTI-FCH-2015-1, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 3239138.75
EU funding (EUR): 2500513.75
Participants: 10
Project status: CLOSED

The overall goal of ECo is to develop and validate a highly efficient co-electrolysis process for conversion of excess renewable electricity into distributable and storable hydrocarbons via simultaneous electrolysis of steam and CO2 through SOEC (Solid Oxide Electrolysis Cells) thus moving the technology from technology readiness level (TRL) 3 to 5. In relation to the work program, ECo will specifically: • Develop and prove improved solid oxide cells (SOEC) based on novel cell structure including electrode backbone structures and infiltration and design of electrolyte/electrode interfaces to achieve high performances and high efficiencies at ~100 oC lower operating temperatures than state-of-the-art in order to reduce thermally activated degradation processes, to improve integration with hydrocarbon production, and to reduce overall costs. • Investigate durability under realistic co-electrolysis operating conditions that include dynamic electricity input from fluctuating sources with the aim to achieve degradation rates below 1%/1000 h at stack level under relevant operating conditions. • Design a plant to integrate the co-electrolysis with fluctuating electricity input and catalytic processes for hydrocarbon production, with special emphasis on methanation (considering both external and internal) and perform selected validation tests under the thus needed operating conditions. • Test a co-electrolysis system under realistic conditions for final validation of the obtained results at larger scale. • Demonstrate economic viability for overall process efficiencies exceeding 60% using results obtained in the project for the case of storage media such as methane and compare to traditional technologies with the aim to identify critical performance parameters that have to be improved. Perform a life cycle assessment with CO2 from different sources (cement industry or biogas) and electricity from preferably renewable sources to prove the recycling potential of the concept

Keywords: co electrolysis,high pressure,system,durability,micro structure