Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Africa-Europe BioClimatic buildings for XXI century (ABC 21)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Italy,France,Portugal,Morocco,Togo,Senegal
Call: Bioclimatic approaches for improving energy performance in buildings in Africa and Europe (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2023-05-31
Duration (months): 33.0
Total project cost (EUR): 1082312.5
EU funding (EUR): 1082312.5
Participants: 10
Project status: SIGNED

The globalisation trends in the building sector resulted in the adoption of inadequate design solutions, especially for warm weather regions, which replicated designs that are far from sustainable or energy-efficient. The obsession with glazed-unshaded buildings is the most visible aspect of this trend. These buildings perform badly even in central Europe, and yet we see an ever-growing number of glass tower buildings in Africa. The need to fight this cycle of inadequate building practices is clear, especially considering a climate change scenario. In light of this challenge, it is urgent to investigate the best sustainable design and construction examples from warm regions worldwide. Design strategy involves bioclimatic approaches and other low-energy solutions for maintaining comfort levels in warmer climates. Some of these solutions already exist in Africa and only need to be disseminated and adapted to other regions. Inspiration might originate from nature, like the Saharan Silver ants, with enhanced optical reflection and radiative heat dissipation capabilities. This concept was recently successfully adapted as a building surface finishing layer. Combining these state-of-the-art approaches with the best bioclimatic solutions will be the hallmark of the ABC 21 project.
Saadian Intellectual and Cultural Life (SICLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-02-01
End date: 2021-09-30
Duration (months): 68.0
Total project cost (EUR): 1959283.0
EU funding (EUR): 1959283.0
Participants: 1
Project status: CLOSED

The aim of the interdisciplinary investigation project SICLE is to investigate in a completely new way the intellectual and cultural history of the Saadian period in Morocco (1554-1660), using primarily the Saadian sultans’ library, exceptionally preserved as a ‘time capsule’ in the El Escorial monastery following king Felipe III’s decision to include it in his own library. The period is a time of direct involvement of Morocco in international politics and exchanges, both in their East-West (with the Ottoman empire) and North-South (with Europe) dimensions, without forgetting Timbuktu and the Songhay empire conquered by Ahmad al-Mansur, the most brilliant ruler of the dynasty. The manuscripts kept in El Escorial mirror the interests and the tastes of the Saadian rulers and of the elite at large. The paratextual information they contain (but ignored by the catalogues) like the various notes, the colophons, the illuminations or the bindings will be systematically collected and analyzed in a trans-disciplinary approach which can be defined as an ‘archaeology of the book’, combining codicology, philology, archaeometry, anthropology and art history. The same approach will be applied to the books of the ‘ordinary people’ from Saadian times preserved in Moroccan collections. SICLE goals are to offer: a) a history of the Saadian sultans’ library and an analysis of their interests; b) a cultural and intellectual history of Morocco during the 16th century, with groundbreaking studies on the history of the book, on its economy and on education; c) an evaluation of the relationship with the ‘outside’ (Christian Europe, the Ottoman empire and sub-Saharan Africa) and the possible influence it had on Saadian intellectual production. Special attention will be paid to the Jewish and Morisco communities in their role of culture brokers.

Keywords: maghreb,intellectual history,king s kibrary 17th century
COP21: Results and Implications for Pathways and Policies for Low Emissions European Societies (COP21 RIPPLES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: South Africa,Italy,Italy,Germany,Germany,Belgium,Bulgaria,China,Poland,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Brazil,United Kingdom
Call: Pathways towards the decarbonisation and resilience of the European economy in the timeframe 2030-2050 and beyond (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-12-01
End date: 2020-01-31
Duration (months): 38.0
Total project cost (EUR): 2986923.75
EU funding (EUR): 2986923.75
Participants: 19
Project status: CLOSED

The COP21 outcome represents an important new strategic context for EU climate policy. Analysing the implications of this new context requires an interdisciplinary approach, combining analysis of the evolution of the international climate regime as well as of NDCs and their socio-economic implications. Such analysis is also urgent, given the timelines imposed by the Paris Agreement for a “facilitative dialogue” in 2018 with a view to creating the conditions for the revision of NDC in 2020. In order to address the context described above, this project has four objectives : 1) Assess the adequacy of the NDCs submitted at COP21 in light of the global temperature target of limiting warming to 2°C/1.5°C. Through the analysis of GHG scenarios and energy system scenarios , the project will pay particular attention to the concrete system changes induced by NDCs, and compare them with the changes required to meet the global temperature limit. The project will also analyse scenarios limiting warming to 1.5°C, and the impact of NDCs on other sectors. 2) Assess the implications of NDCs and deeper mitigation pathways on other European socio-economic objectives. By integrating GHG and energy system scenarios into a range of different macro-economic, global energy system models and other quantified methodologies, the project will investigate implications for European socio-economic objectives related to innovation and technology deployment; trade and competiveness; investment, financial flows and economic growth (“green growth”); and global energy markets and energy security. 3. Assess the adequacy of the outcomes of COP21, and the implications and opportunities emerging from ongoing UNFCCC negotiations. The project will undertake a social sciences-based (in particular international law and international relations) assessment of the outcome of COP21. 4) Policy recommendations for EU climate policy and climate diplomacy.

Keywords: international climate negotiations
Developing a cure for retinitis pigmentosa due to Usher syndrome (GeneVision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The GeneVision proof-of-concept project spins from a major discovery made by the principle investigator (PI) within the RetGeneTx ERC project demonstrating that dual AAV vectors expand AAV DNA transfer capacity in the retina thus allowing delivery of genes whose size cannot be packaged in single AAVs. Thus, dual AAV vectors allow gene therapy of those inherited blinding conditions, like Usher syndrome type Ib (USHIB), Stargardt disease or other forms of retinitis pigmentosa, due to mutations in large genes from which the AAV platform, the best to date for in vivo gene therapy, was so far precluded. GeneVision’s objective is to bring this initial proof-of-concept in animal models up to commercialization for one retinal application, USHIB, which is particularly severe and early onset. By exploiting both the Orphan Drug Designation obtained from the European Medicina Agency and two patent applications based on data generated by the PI during its consolidator ERC grant, GeneVision will support the early phase clinical development to bring this very innovative gene therapy platform for retinitis pigmentosa up to commercialization. To do so the project plans to validate the business plan already outlined in the proposal, and seek seed funding to create a start-up company which would engage in all activities required to develop a phase I/II trial. If this is successful, the longer plan is to obtain two additional rounds of funding to support a pivotal trial to complete the data required to obtain market authorization and start commercialization. . The success of this project will lay the foundations for the development of therapies for other retinal and non-retinal diseases using dual AAV vectors.

Keywords: gene therapy,genetic blindness,dual aav,usher syndrome,start up
MobIle health-Care system for monitoring toxicity and symptoms in cAncer patients Receiving diseasE-oriented therapy (iCARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-06-01
End date: 2017-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 105000.0
Participants: 2
Project status: CLOSED

The project aims at developing a pre-commercial solution, till preparing its entrance to the market, of a new cost-effective mobile system for technology-aided home treatment with oral drugs in cancer patients. This project stems from the ERC Starting Grant VISION, which demonstrated the effectiveness of model-driven approaches for adaptive context-aware resource configuration in internetworking smart objects and wireless multimedia sensor networks. Pervasiveness and easiness of usage that internetworking smart objects may offer to cancer patients in their everyday life, constitute the baseline of the iCARE system. The use of oral anticancer drugs in modern oncology creates a paradigm shift, challenging traditional attitudes towards cancer care and oncology services. Daily use of oral anticancer drugs assumed at home is a challenging commitment for patients, since in non-traditional settings even the patient’s adherence is affected by self-administration and lack of supervision in managing side effects. The iCARE project will prototype specifically designed devices interfaced to the patient’s smartphone to constantly monitor and periodically report to the medical unit the compliance to the therapy. A novel smartphone’s APP will collect patients’ feedbacks about side effects through daily questionnaires, in full compliance with relevant cancer medical protocols. To strengthen the ICT coordination of care services, provided tools will be tested over tens of volunteering patients and constantly enhanced based on feedback from patients and physicians to increase easiness of usage and effectiveness of the technology-aided methodology. Since orally administered chemotherapy and biologic agents are expected to increase dramatically in the near future, the iCARE system has the potential to create a high socio-economic impact, enabling a wide spread of home treatment of cancer patients that preserve their confortable lifestyle, and allowing significant resource savings.

Keywords: health care sciences and services,systems engineering,sensorics,actorics,automation,web and information systems,database systems,information retrieval
Signaling dynamics in the control of cell proliferation and differentiation during development and homeostasis (SignalingDynamics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Tight coordination between proliferation and differentiation is key to proper development and homeostasis of multicellular systems. Cell-cell communication via signaling pathways has long been studied in this context. Encoding information in the temporal change of a signal, i.e. signaling dynamics, can ensure information transmission to be specific and accurate. Studies exemplifying the relevance of dynamic signaling raise the critical question: What is the function of signaling dynamics in controlling proliferation and differentiation at tissue level? My expertise in signaling dynamics, advanced light microscopy, microfluidics, development, cell cycle research and organoid culture provides a unique skill-set for the functional investigation of dynamic signaling during development and tissue homeostasis using two model systems: Somitogenesis in vertebrate embryos is the sequential segmentation of growing tissue. It is controlled by signaling gradients and oscillations. Whereas differentiation has been studied extensively, it remains elusive (A) how cell proliferation is regulated and (B) whether there is a link between proliferation and signaling dynamics. Indeed, our preliminary data strongly indicate that cell proliferation impacts on signaling oscillations. Homeostasis of adult tissue is also maintained by signaling pathways balancing proliferation and differentiation. In the small intestine some of these pathways have recently been shown to be dynamic. We will apply a systematic approach to understand (A) are signaling pathways in the intestine dynamic and (B) what is the function. Our preliminary data support that combining organoid culture, light-sheet microscopy and microfluidic perturbation allows quantification and functional analysis of signaling dynamics. By comparing signaling dynamics in development and homeostasis we will derive general principles of dynamic signal encoding in multicellular systems.

Keywords: microfluidics,oscillations,dynamic signaling reporters,organoids,proliferation,differentiation,stem cell,somitogenesis,small intestine
European Researchers' Night in Sweden 2021: ForskarFredag 2021 (FF2021)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Sweden
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-04-01
End date: 2022-03-31
Duration (months): 12.0
Total project cost (EUR): 566241.5
EU funding (EUR): 130000.0
Participants: 1
Project status: CLOSED

ForskarFredag (Researchers' Friday) is a national event and Sweden?s most widely dispersed science festival. ForskarFredag 2021 (FF2021) will consist of events arranged in 27 cities on 24-25 September and an online programme, enabling anyone in Sweden to participate. The non-profit association VA (Public & Science) has coordinated FF annually since 2006. FF2021 builds on previous years, drawing on experience, contacts and the ever-increasing profile. The FF motto is: "Researchers are ordinary people with extraordinary jobs". At FF2021, members of the public will be invited to meet researchers and participate in interactive activities, designed to stimulate dialogue and show that research is exciting and relevant to everyday life: debates, science cafes, competitions, shows, experiments and hands-on activities. The common theme 'What will life be like in the future?' will inspire activities exploring the role of research in tackling societal challenges. In collaboration with 6 other ERN projects, a set of activities will be offered in all 7 countries, highlighting the European dimension of research. Young people aged 6-19 are a key target audience. A school programme will offer numerous opportunities for encounters with researchers. The Borrow a Researcher concept will allow classes across Sweden to meet a researcher virtually or in school. A national mass experiment (citizen science project), inviting pupils to work with researchers, will be conducted as part of the awareness campaign, involving appr. 5,000 people. Local events (physical and digital) expected to reach 26000 attendees will be planned and executed by 11 Subcontractors and 21 External Partners. Each event builds on local strengths and uses local networks to give the highest possible impact. All event organisers share experiences in a national network. VA is responsible for the coordination, quality assurance, common activities, national identity, awareness campaign and impact assessment of FF2021.

Keywords: national event,research,science,hands on activities,general public,citizen science,collaboration with other ern projects,borrow a researcher,mass experiment,science festival,forskarfredag
Smart Sharing (SMASH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2019-08-31
Duration (months): 30.0
Total project cost (EUR): 1592500.0
EU funding (EUR): 1114750.0
Participants: 1
Project status: CLOSED

SMASH, Smart Sharing Device by Greenspider®, is a unique device fulfilling the main emerging requirements in the market of innovative mobility: • Geo-Location of distributed mobility resources: fleets, vehicles, charging and parking stations, gates, boxes, and any generic points of interest. • Mobile authentication of the users that can access and use the shared resources. • Resource control features; using the user smartphone to exchange commands in proximity and remote SMASH transfers the features that are today only available for Connected Cars to scooters, electric bikes, and any kind of vehicle and mobility resources, so that the users can see the position of the accessible objects, and use their smartphone as an access key for the smart mobility. The Vehicle sharing operators are the prime customers of SMASH. They are proliferating worldwide, but their deployed systems are currently characterized by poor interoperability, service coverage restricted to the center of the cities, and poor capability to dynamically extend fleets. Peer-to-peer (P2P) vehicle-sharing is a key market for SMASH. P2P is a process expanding worldwide, whereby existing vehicle owners make their vehicles available for others to rent for short periods of time. The participating car owners are able to charge a fee to rent out their vehicles when they are not using them. The Participating renters can access nearby and affordable vehicles and pay only a convenient fee, for the time they need to use them. SMASH, bringing the two parties together enables a global expanding community of users and available resources. SMASH enables Open Source vehicle sharing. In the next future, thanks to SMASH users will be able to choose and access a wide and expanding range of vehicles, with a smart access and reliable pay-per-use. Many heterogeneous and interoperable vehicles will be connected and available in sharing.

Keywords: smart sharing,fleet management,vehicle sharing,peer to peer
Mastiha treatment for healthy obese with NAFLD diagnosis (MAST4HEALTH). (MAST4HEALTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Spain,Italy,Italy,Bosnia and Herzegovina,Serbia,Greece,Greece,France,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 2124000.0
EU funding (EUR): 2124000.0
Participants: 15
Project status: CLOSED

MAST4HEALTH is set on the concept of a multidisciplinary approach to assess a non-pharmacological intervention for managing NAFLD/NASH, one of the most common complications of obesity and diabetes mellitus in Western populations affecting approximately 50% of diabetics and 76% of obese patients. Because of limitations in current NAFLD treatment therapies, many new efforts focus on exploring non-pharmacologic means for managing the disease and in particular through dietary substances or bioactive phytochemicals in fruits, vegetables, and plants or their products. MAST4HEALTH aims at exploring the effect of Mastiha, a natural product of Greece which was recently shown to possess antioxidant/anti-inflammatory and lipid lowering properties. We designed a multicenter randomized double blind placebo controlled (parallel arm) clinical trial to test the effectiveness of Mastiha supplement as new non-pharmacologic strategy for NAFLD/NASH treatment. MAST4HEALTH will explore gene-diet interactions, more specifically the potential personalized activity of the Mastiha, and correlate genetic and epigenetic markers with metabolomic and intestinal microbiota profiles pre- and post-intervention. The effectiveness of the proposed intervention will be evaluated via clinical and laboratory markers of the disease. To this end, MAST4HEALTH will train a number of researchers and PhD students in multidisciplinary approaches of this survey. MAST4HEALTH is expected to build and enhance cooperation among partners meanwhile strengthening the interaction between our academic and non-academic sectors

Keywords: nafld,mastiha,obesity,genomics,gene nutrient interaction