Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Managing Interactions between International Agreements: Dealing with Diversity in Global Climate Governance (CLIMATEGOV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-07
End date: 2011-12-06
Duration (months): 18.0
Total project cost (EUR): 124030.6
EU funding (EUR): 124030.6
Participants: 1
Project status: CLOSED

The proposal seeks to support the career development of an experienced researcher, by completing an interdisciplinary research project on dealing with interactions in global climate governance, and enabling the fellow to acquire new knowledge and academic skills at a renowned university. The scientific objectives of the research are to analyse how the diversity in global climate governance, and interactions between different international agreements have affected the normative development of these agreements; to assess legal techniques and political mechanisms for dealing with the diversity in global climate governance; and to provide policy and research recommendations, and disseminate the findings of the research project. Three cases are used to illustrate the interactions, and to assess the legal and political options to manage interactions. These cases allow for a comprehensive analysis of the various forms of fragmentation in global climate governance, while at the same time providing broader insights for other areas of international law and global governance studies. The host institution for the fellow is the Environmental Change Institute (ECI) at the University of Oxford. ECI hosts many experienced scholars relevant to the proposed research, and has an excellent reputation in interdisciplinary climate change research. The Institute also has an outstanding track record of training researchers. The research training objectives are to contribute to the fellow’s writing and publication skills, through significant progress in completing his doctoral thesis and the publication of peer-reviewed articles; to enhance the fellow’s knowledge on interactions in global environmental governance; to participate in postgraduate courses, lectures, seminars and other events held at the University of Oxford; and to collaborate and interact with scholars at ECI on research areas of mutual interest.

Keywords: global change mitigation strategies (climate change),environmental policies (climate change),international law,governance,international relations,environmental law
Markers of prenatal metabolic plasticity and assessment of their reversibility by postnatal interventions (METABOLIC PLASTICITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 238375.3
EU funding (EUR): 238375.3
Participants: 1
Project status: CLOSED

Inactivity and nutritional aberrations result in an expanding population of individuals with compromised metabolic function including obesity and insulin resistance. From this pool of individuals an increasing percentage develops overt diabetes leading to vast personal and social burden. Natural interventions are beneficial and exercise accompanied by weight loss can reverse insulin resistance, at least partially. Metabolic stress history has significant impact on the long-term organization of metabolic adaptive responses, especially during early stages of life (intrauterine and early postnatal). Individual variability of genetic background and metabolic-stress history coincides with the need for diverse interventions, in order to optimize metabolic control. Linking distinct markers of metabolic aberrations with genetic and metabolic stress history components will provide tools for individualized approaches for treating patients, which will facilitate our efforts to “normalize” a maladaptive metabolic profile in the context of a sedentary/hypercaloric life style. The general aim of the proposed study is to define the experimental tools that will shape a model animal system for the study of the metabolic impact of interventions that may be used therapeutically in states of compromised metabolism. The specific aims include (a) the identification of serum and tissue markers that specifically characterize the metabolic derangements associated with distinct mouse models of in utero metabolic risk and (b) the examination of the effects of nutritional, medicinal, hormonal and physical activity interventions on these markers and their association with changes in insulin resistance and metabolic balance. Establishing an experimental model that will facilitate the assessment of the metabolic effects of medicinal and, primarily, life-style measures, such as exercise and nutritional/caloric modifications, will help the study of debilitating states such as diabetes and cachexia.

Keywords: health sciences,diabetes,insulin resistance,mtor,low birth weight,energy metabolism,metabolic markers
C4 photosynthesis transcriptomics (C4TRAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 179603.2
EU funding (EUR): 179603.2
Participants: 1
Project status: CLOSED

C4 photosynthesis concentrates CO2 around RuBisCO and so increases the efficiency of photosynthesis. In the vast majority of C4 species the biochemistry of photosynthesis, and also the cell biology and development of leaves is altered. Despite these complex changes, the C4 pathway has evolved at least 45 times independently. Because C4 photosynthesis is more efficient in C4 plants, it has been proposed that engineering the C4 pathway into C3 crops such as rice would be beneficial for productivity. For this to be feasible, we need a better understanding of the basic mechanisms underlying C4 photosynthesis. I aim to investigate mechanisms generating cell specific gene expression in C4 plants, and will use C. gynandra, the most closely related C4 species to the C3 model Arabidopsis. I will generate comprehensive profiles of transcript abundance in mesophyll (M) and bundle sheath (BS) cells using laser capture microdissection and Illumina sequencing. I will also generate knock-down lines of C. gynandra for 20 transcription factors that we have identified as candidates for maintaining patterns of gene expression required for C4 photosynthesis. The project will significantly increase our understanding of basic mechanisms underlying C4 photosynthesis, and therefore may facilitate introduction of C4 traits in C3 crops.

Keywords: photosynthesis,transcriptomics,new generation sequencing,cell specificity,cleome,arabidopsis,mesophyll cells,bundle-sheath cells
Spin torque oscillators with applications in non digital computing science and communications. (SPINTORQOSC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-04-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 234337.9
EU funding (EUR): 234337.9
Participants: 1
Project status: CLOSED

The project aims at studying spin-wave excitations from nanocontacts and implementing biological inspired computations with wavefronts in nano-structures, likely in terms of spin waves in ferromagnetic films. This implies building a bridge between Mathematical Neuroscience and Applied Physics. It is also of great importance to create a new research line at the \emph{Magnetics Laboratory Group} at UB with Prof. J. Tejada and Dr. J. M. Hernandez based on nanofabrication of magnetic devices sensors in order to study gyromagnetic phenomena and the patterning of spin dynamics at the quantum level. Nanoscale, current controlled spin-torque oscillators (STOs) are of great fundamental interest and also of interest for signal processing and communication, including on-chip communication via spin-wave propagation. However, the fundamental characteristics of the spin-waves emitted by STOs are unknown. STOs, consisting of a point contact to a thin film ferromagnet (FM), were first proposed theoretically in 1996. High DC current densities generate a high-frequency dynamic response (up to 100 GHz) in the FM layer and can result in the emission of spin-waves. Studies of STOs to date have relied primarily on electronic transport characteristics. Further studies have shown these oscillations may be phase-locked to an external rf source, via a process known as injection locking, providing a means of conducting time-resolved spatial imaging. The aim of the proposed work is to study the fundamental characteristics of spin-waves generated from STOs using full-field transmission x-ray microscopy (TXM), combined with x-ray magnetic circular dichronism (XMCD) to provide magnetic contrast. We will determine the physical requirements for implementation with STO’s of a novel computational framework based on polychronous wavefront dynamics using temporal and spatial patterns of activity in pulse-propagating media.

Keywords: applied physics,magnetisation,spintronics,nanofabrication,spin waves,spin torque oscillators,computational neuroscience,signal processing,wavefront computations,oscillators
X-ray pump-probe spectroscopies - new tools to study ultrafast surface dynamics - (X-RAY PUMP-PROBE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 159381.8
EU funding (EUR): 159381.8
Participants: 1
Project status: CLOSED

Recent progress in laser science allows the creation of femto- to attosecond X-ray light pulses and paves the way for a completely new generation of experiments investigating ultrafast processes in biology, chemistry and physics. Intensive research efforts worldwide are pursuing the implementation of “pilot” experiments that demonstrate the scientific potential of this area. However, the challenging nature of femtosecond X-ray sources requires experts with interdisciplinary training in X-ray laser-science and in the research areas that can benefit from its use. The goal of the proposed project is to develop and establish X-ray pump-probe spectroscopies using high-harmonic light sources to study femtosecond surface dynamics. Three ultrafast surface science areas will be addressed: surface magnetism, chemical reactions and phase transitions. The proposed interdisciplinary experiments will yield new insight in femtosecond quasiparticle interactions and will also impact possible applications in magnetic memory production, catalysis and organic materials. The applicant is an expert in surface science, who will complement his skills in organic materials, femtochemistry and high-harmonic X-ray generation with the Kapteyn-Murnane Group at JILA (USA), who are leading scientists in the field. The proposed project is at the cutting edge of ultrafast surface science and will promote EU research in this field during the return phase with Prof. Aeschlimann (GER) at the University of Kaiserslautern, who is one of the global key opinion leaders for ultrafast phenomena. The proposed project will help the fellow researcher gain professional maturity and to actively participate in shaping the next generation of ultrafast research with X-ray pulses, an area that is rapidly expanding with increasing worldwide availability of high harmonic and free electron laser light sources.

Keywords: physical sciences,ultrafast surface physics,nonlinear optics,attosecond spectroscopy,magnetism,electronic,magnetic and superconductive properties,chemical reaction dynamics,phase transitions
Supersymmetric and model independent bilepton searches at the LHC: an experimental and phenomenological approach (SUSYBILEPLHC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-12-31
Duration (months): 29.0
Total project cost (EUR): 171828.6
EU funding (EUR): 171828.6
Participants: 1
Project status: CLOSED

In this project we propose a new study of searches for non-standard particles known as bileptons, in the context of the Large-Hadron-Collider (LHC) energies. Bileptons are bosons which couple to two leptons, and which carry two units of lepton number, and are predicted by several beyond Standard Model scenarios, including supersymmetric extensions. A bilepton signal would be strong evidence of new physics and its discovery would change our understanding of Nature. We propose to look for model independent bilepton signals as well as to study supersymmetric extensions that predict the existence of these particles. To achieve this goal the project is divided in three major parts. In the first part we will study detector signatures of models that predict the existence of bileptons, such as the Minimal 331 Model and its supersymmetric version. In the second part we will study the ATLAS experiment model independent discovery potential for bileptons, including its most important backgrounds. The third and most important part will be the LHC data analyses. We should first be guided by existing work with bileptons, as we will use the data as soon as it is available. The performance of new and more realistic simulations in the context of ATLAS will however, be fundamental to understand the collision data results. The project is intended to begin in perfect timing with the LHC restart schedule and has the potential to lead to a major discovery.

Keywords: physical sciences,elementary particle physics,beyond standard model,supersymmetry,bileptons,lhc data,atlas detector,monte carlo simulation
FUNCTIONAL ANALYSIS OF THE BLUMERIA HAUSTORIA - BARLEY INTERACTOME (BLUMERIA EFFECTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

Blumeria graminis f. sp hordei is an economically important pathogen of cereals that causes barley powdery mildew. This obligate biotrophic pathogen is able to penetrate the cell wall barrier and develop a highly complex intracellular structure -the “haustorium”. This structure has long been known to actively take up nutrients, but it is now also believed to control host perception and defence, enabling the invading pathogen to survive, avoid and suppress rejection responses. How this is achieved is unknown, but current thinking postulates that this control is mediated by protein effectors secreted by the pathogen into the host cells. In this proposal I aim at discovering details of the molecular mechanisms by which B. graminis establishes control of the host barley cell through the action of the haustorium and effectors. To do this, I will define a panel of genes that encode candidate effectors proteins based on current data available and on new proteogenomic data generated at Dr. Spanu’s laboratory (Imperial College London, UK) in collaboration with the University of Reading (UK). These candidates will be cloned in vectors for functional analysis and expression as recombinant proteins. Effector proteins that alter infection levels will be identified by in vivo assays developed and used successfully by Dr. Wise’s group at USDA (USA). These effectors will be used to ‘’fish’’ host proteins they bind to and interact with, which will define candidate effectors targets. Evidence of interactions will be sough both, in the plant cells themselves and in extracts from infected plants. I will use the same approach to identify barley or Blumeria proteins which interact with Bln-1, the recently discovered modulator of susceptibility in Blumeria/barley interactions. Understanding of the molecular mechanisms underlying disease in the cereal mildew has the potential of aiding future developments in disease resistance and management.

Keywords: haustorium,effectors,blumeria graminis,proteogenomics,functional analysis,powdery mildew
Multifunctional Metal-Organic Frameworks (MULTIMOF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

The project MultiMOF (Multifunctional Metal-Organic Frameworks) is a natural step beyond the work developed by the applicant during his PhD thesis in Molecular Magnetism. It intends to undertake an extensive scientific program on the design and physical characterization of a broad range of multifunctional Metal-Organic Frameworks (MOFs). Mutifunctionality will arise from the combination of their intrinsic properties such as lightness, porosity, flexibility or biocompatibility with magnetism or chirality and the interplay between them. MOFs can be defined as nanoporous crystalline compounds consisting of metal ions or clusters coordinated to multidentate organic ligands to form one-, two-, or three-dimensional structures. Resulting from the introduction of permanent porosity, these molecule-based materials have attracted important attention in the last decade because of their promising application in gas storage, separation, ion exchange, catalysis or drug delivery. Taking advantage of expertise of the University of Liverpool materials chemistry group in the synthesis and characterization of MOFs, we intend to introduce electronically active transition metal (TM) extended units and optically active organic linkers in these materials in order to combine magnetic or optical properties with those resulting from their open structure. This approach will result in the design of a whole set of magnetic MOFs including additional functionalities, which could be of remarkable importance for the future development of porous low-density magnetic materials, switchable magnets, chiral magnets, magnetic sensors or higher level multifunctional materials. In this way, the researcher will embark on a multidisciplinary work plan, learning new concepts in Coordination Chemistry and Crystal Engineering, essential for the design and isolation of these open frameworks, and Solid-State Physics, employed in the study and tuning of physical properties exhibited by these materials.

Keywords: inorganic chemistry,molecular chemistry,molecular magnetism,nanoporous materials,cristallography,condensed matter properties,solid state physics
Human TSLP and OX40L as targets of therapeutic intervention for allergic asthma. (TSLP IN ASTHMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 139000.0
EU funding (EUR): 139000.0
Participants: 1
Project status: CLOSED

Epithelial cell derived Thymic Stromal Lymphopoietin (TSLP) instructs dendritic cells (DCs) via the expression of OX40L to induce Th2 polarization and is both necessary and sufficient for the development of airway inflammation. TSLP and OX40L are therefore promising targets for the development of new therapies for allergic asthma. The aim of this project is to study the potential of targeting human TSLP and human OX40L for intervening with the initiation and/or progression of allergic asthma in vivo, using a humanized mouse for asthma model. The proposed model is unique since it enables to particularly evaluate the effect of potential therapeutic compounds, in our case (anti-)TSLP and (anti-)OX40L, on human haematopoietic cells in an in vivo system. Information acquired in this project should therefore lead to important go-no go decisions to further advance this therapeutic strategy to the clinic. All experimental work will be performed in the laboratory of Prof. Bart Lambrecht (University Hospital, Ghent, Belgium). Prof. Bart Lambrecht is an expert on murine models of asthma and is focused specifically on DC biology. In his laboratory all facilities and expertise are available to perform the proposed experiments. In addition, the group heads have extensive experience in mentoring and guiding post docs. The proposed work will allow me to further develop my recently founded translational research line directed at the immunopathology of allergic asthma in young children. On return to my home institute I will incorporate my research in the Center of Molecular and Cellular Intervention of the University Medical Center Utrecht (head Prof. B. Prakken). The combination of my current expertise in human immunology, my clinical expertise as an MD-pediatrician and the expertise I will gain in the laboratory of Prof. Lambrecht on mouse models of asthma will enable me to take a strong competitive research position and as I hope to contribute to European excellence.

Keywords: health sciences,allergic asthma,tslp,ox40l,humanized mouse model,dendritic cells,mast cells,basophils,translational medicine