Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PLASTIC WASTE VALORIZATION TO CLEAN H2 AND DECARBONIZED CHEMICALS BY CATALYTIC DECONSTRUCTION WITH NOVEL IONIC LIQUID-BASED CATALYTIC SYSTEMS (WASTE2H2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,France
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2984716.25
EU funding (EUR): 2984716.25
Participants: 6
Project status: SIGNED

Daily basis used plastics cause a huge amount of waste having an enormous impact on the environment and living species at the end-of-life of plastics disposal. In fact, around 300 million tons of plastic are produced annually in the world and only small percentage, less than 9% according to UNEP, of this plastic is recycled, 12% is incinerated and the 79% left generates big contamination problems. There are already different ways, not all of them economically viable, to valorize plastic waste (PW) e.g., chemical recycling to feedstocks and energy. The smart management and valorization of PW generated is a major challenge to be addressed by the scientific community. Furthermore, the decarbonization of all sectors of activity becomes of paramount importance and hydrogen is set to play a key role in decarbonizing hard-to-electrify sectors, as well as represent a zero-carbon feedstock for chemicals and fuel production. But for H2 to play the desired role in the energy transition, the scientific community must face the big challenge of decarbonizing H2 production at a competitive cost. Consequently, WASTE2H2 is proposing a novel method where innovative Ionic Liquid-based catalytic systems are combined with microwave (MW) irradiation to selectively produce highly pure clean H2 and valuable decarbonized chemicals (solid carbon) from PW, addressing simultaneously PW remediation and global climate change mitigation. WASTE2H2 add to novelty significant breakthroughs vs. other routes for PW management and H2 production: i) plastic waste deconstruction by single-step method powered by renewable electricity and working under mild conditions; ii) fast production of highly pure H2; iii) valuable solid carbon production as sole decarbonized co-product, with easy recovery for its commercialization; iv) expected long lifespan of catalytic system, easy recovery and reuse; v) reducing significantly the energy consumption due to MWs; and vi) high potential to reduce H2 production cost.

Keywords: catalysis ionic liquids plastic waste management circular economy decarbonized materials microwaves clean energy
Differentiation and characterisation of brain-derived extracellular vesicles from the peripheral blood for understanding the neuropathophysiological mechanisms of migraine. (DiBDEV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-13
End date: 2024-06-12
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: CLOSED

Migraine is a major disease burden on society but remains poorly understood. The onset of migraine with aura has been linked to cortical spreading depolarisation (CSD) and Professor Turgay Dalkara (the supervisor) found that inducing CSD in animal models led neurons to release inflammatory proteins in extracellular vesicles (EVs). Because brain-derived (BD)EVs cross the blood-brain barrier and their composition reflects their cellular and temporal origin, they represent biomarkers that, if isolated from the peripheral blood of migraine patients, could give an unparalleled insight into cell-specific neuroinflammation in migraine. However, current methods to isolate cell type-specific BDEVs from the blood insufficiently distinguish them from EVs of other tissues, obscuring crucial insights into cell-specific processes. Here, I (Adam Bennett, the researcher) will develop a workflow to isolate cell type-specific BDEVs from the blood of migraine patients then temporally characterise them to gain a cell-type specific molecular signature during migraine with aura. This will firstly involve the optimisation and validation of isolating neuron, astrocyte and microglia EVs (using a panel of specific markers) from the brains and peripheral blood of rats. Secondly, cell type-specific EVs isolated at different time points post-CSD evocation in rats will be characterised using proteomics to generate temporal cell type-specific data on the pathological processes post-CSD. Thirdly, with optimised time points, cell type-specific EVs will be isolated from the blood of patients after migraine with aura onset and characterised. In doing so, I will (1) identify previously unknown biomarkers to deepen our understanding of migraine with aura, with possible treatment derivations; (2) create a tool for researchers to investigate other neurological conditions through analysing cell type-specific BDEVs; (3) develop my skillset, publication record, visibility and networks to advance my career.

Keywords: extracellular vesicle,migraine,neuroinflammation,biomarker
Main Group Metals in Oxidation State Zero for Bond Activation and Catalysis (MM-ZERO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2499856.0
EU funding (EUR): 2499856.0
Participants: 1
Project status: SIGNED

Historically, main group metal organometallics are used as stoichiometric reagents in organic synthesis. This holds especially for highly polar s-block metal compounds like BuLi or Grignard’s. Only since the start of this century, it has been recognized that they also make for remarkably versatile catalysts. Parallel to these developments, the low-oxidation-state chemistry of the early main group metals emerged with the seminal isolation of first MgI complexes. Since 2007 numerous examples have been reported. First highly reactive complexes of an s-block metal in the formal zero-oxidation-state (ZOS) were reported by our group (“Strongly reducing magnesium(0) complexes”, Nature 2021, 592, 717). MM-ZERO aims to develop main group metal chemistry in the ZOS. In contrast to transition metals, for which there are many examples of TM(0) complexes, it is a bold challenge to isolate complexes of electron-rich main group metals. This holds especially for the electropositive s-block metals. Devoid of d-orbitals for backbonding, they easily oxidize. Building upon our preliminary work, we propose strategies to advance ZOS main group metal chemistry and push the frontiers of knowledge. Smart ligand design and the introduction of ball-milling are key to access hydrocarbon-soluble complexes with ZOS-metals of groups 1-3. While this first part is of fundamental nature, the second part of the project aims to activate main group metals for hydrogenation catalysis. Preliminary work shows that Ba activated by Metal-Vapour-Synthesis (MVS, i.e. cocondensation in an organic matrix) is an unexpectedly active alkene hydrogenation catalyst. Moreover, in combination with MVS-activated Fe, benzene can be even hydrogenated at 20 °C. Ba/Fe-cooperativity is demonstrated by the fact that both metals alone are not active. Combining abundant main group and 3d-TM’s, it is our ultimate goal to develop sustainable, highly active (de)hydrogenation catalysts for hydrogen storage applications.

Keywords: metal activation ball milling metal vapour synthesis hydrogenation catalysis sustainability
Transforming Data Processing Efficiency: Pioneering Memory Functionality in Silicon Photonics for Sustainable and High-Performance Computing (SYNAPSOTON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

This project aims to address the pressing issue of energy consumption in data transmission and processing by developing materials technology for efficient memory computing. Currently, data centers consume a significant amount of electricity, and traditional computing architectures are inefficient. Neuromorphic computing, inspired by the brain's functioning, offers a promising solution with ultra-fast communication and low energy consumption. Photonic processors, which use light for probing, are particularly attractive for achieving these goals. The project focuses on integrating advanced materials into existing silicon photonic (SiPh) platforms to create efficient reconfigurable circuits. Refractive index tuning methods in Si are limited, and the project seeks to overcome them by integrating materials like Phase Change Materials (PCMs) and suitable 2D transition metal dichalcogenides (TMDs) to demonstrate optical memristors. These materials can emulate neural systems, offering control over switching, energy consumption, heat dissipation, and other crucial parameters. The project's objectives include optimizing materials technology, designing optical memristors based on PCMs and 2D materials, exploring new configurations with PCM+MEMs, investigating memory functionality in VO2, and demonstrating neural response. The goal is to improve data processing speeds while reducing power consumption, ultimately leading to energy-efficient computing. Additionally, the project aims to assess the environmental impact of these advancements through empirical cost comparisons. The researcher envisions that this experience will empower them to become a high-quality academic researcher with a focus on materials photonics. Overall, the project addresses a critical need in the field of computing by developing materials technology for energy-efficient memory computing, aligning with the goals of the European Green Deal towards the pursuit of ultra-fast, low-energy data processing.

Keywords: materials integration,si photonics,optical memristors,neural response
Temporalities, Histories and Methods of Philosophy. Re-thinking the Canon of History of Philosophy and Political Thought (THiMe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

“Temporalities, Histories, and Methods of Philosophy” (THiMe) intends to contribute to the studies on the critique of the Western Canon, through specific reflection on the History of Philosophy and its political nature. The objective is to produce a new methodology of the History of Philosophy and Political Thought to deconstruct and rethink the consolidated canon that determines the way the History of Philosophy is taught and studied nowadays. The ambition is to produce a method capable of fostering emancipatory practices, through the recovery of interrupted histories and neglected legacies of thought, challenging the intrinsic limits of the logic of the Western canon and encouraging a reformulation of the History of Philosophy in inclusive and emancipatory terms. Through the comparative synthesis of M. Gueroult’s, G. Deleuze’s, L. Strauss’ and R. Koselleck’s methods and categories, THiMe’s will provide an innovative conceptuality to renew the idea of History of Philosophy and challenge the exclusionary nature of the canon. It will craft a methodology to investigate the problem of plural temporalities and alternative histories on the specific level of the production of philosophic-political concepts. This approach will produce a knowledge framework that will detect exclusionary biases and flaws hidden in the assumption of a linear and progressive history of philosophical-political thought in general. This framework will be able to unearth and empower philosophical-political possibilities concealed within historical contexts, ultimately proposing a Politics of the History of Philosophy, capable of bolstering emancipatory endeavors in contemporary society. THiMe’s innovative methodology will result from an original combination of the historical-conceptual method and dialectical method, which will make visible the production of concepts and philosophical historiographies as polemical products of socio-political historical conjunctures.

Keywords: history of philosophy,critique of western canon,history of political thought,deleuze,gueroult,strauss,koselleck,temporalities,conceptual history,neglected legacies,alternative pasts
INTERCULTURAL AND TRANSCULTURAL COMPETENCE THROUGH COLLABORATIVE CULTURAL EXPRESSION (INTRACOMP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Norway,Belgium,New Zealand,Finland,Italy,United Kingdom,Serbia,Slovakia,Greece,Papua New Guinea,Hungary,Germany
Call: Arts and cultural awareness and expression in education and training (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 2996651.25
EU funding (EUR): 2996651.25
Participants: 13
Project status: SIGNED

Amidst the unprecedented speed and scale of forced migration and climate mobility in Europe, arts in education has a significant role in promoting social inclusion, diversity and cohesion. Critically exploring cultural hierarchies, divisions and exclusions within arts and education, INTRACOMP develops methods, digital resources and frameworks for advancing Intercultural and Transcultural Competence (ITC) in lifelong learning in Cultural Awareness and Expression. Aligned with NEB, ITC inspires “Together” and “Beautiful” through collaborations on innovative, meaningful, complex and temporary expressions of culture, and enables arts learners to continually transform paradigms and social behaviours. INTRACOMP empowers this disposition and capability through the research and innovation of a viable competence framework (for individuals, groups, organisations and systems) that identifies, evidences, evaluates and scaffolds ITC in performing arts education, from ECE to tertiary and community contexts. To achieve this, the transdisciplinary INTRACOMP consortium explores ITC within diverse societal locations in Northern, Southern and Eastern Europe, through partners situated in cultural organisations and tertiary institutions in Norway, Belgium, Germany, Finland, Italy, the UK, Serbia, Slovakia, Greece and Hungary. INTRACOMP partners in New Zealand and Papua New Guinea provide further opportunities to extend these education and community arts interventions in the Global South, questioning Eurocentric assumptions regarding ITC, acculturative stress and arts in education. The resulting ITC Framework provides learners, teachers, groups and organisations with a common reference point for ITC and its complex internal dimensions and proficiency levels. Through this integrated and multi-pronged approach, arts in education will enhance the inclusion and ITC of all children and young people in Europe and beyond.

Keywords: intercultural,transcultural,competence,music,dance,drama,migration,inclusion,transdisciplinary,education
Physical Cognition for Intelligent Control and Safe Human-Robot Interaction (Sestosenso)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,Spain,France,Slovenia,Sweden,Latvia,Netherlands,Greece,Switzerland,United Kingdom
Call: Pushing the limit of robotics cognition (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4157056.25
EU funding (EUR): 4157054.5
Participants: 14
Project status: SIGNED

Sestosenso develops technologies for the next generations of collaborative robots capable of self-adapting to different time-varying operational conditions and capable of safe and smooth adaptation from autonomous to interactive when human intervention is required either for collaboration or training/teaching. The project proposes a new sensing technology from the hardware and up to the cognitive perception and control levels, based on proximity and tactile sensors embedded in the robot body, providing a unified proxy-tactile perception of the environment, required to control the robot's actions and interactions, safely and autonomously. Sestosenso is motivated by the industrial need to integrate workers with robots and the need for robots that could operate safely without out-of-the-robot infrastructure, thus reducing robot setup times and costs and increasing the flexibility of the shopfloor configuration. The Sestosenso technology is demonstrated by three Use Cases of industrial interest: cooperative assembly (automotive), handling and packaging (logistics), and cooperative harvesting (agriculture).

Keywords: robotic cognitive perception,human robot interaction,robot sensors,robot safety,collaborative robots
Tumor acidosis targeted delivery of immunotherapy by Marker-Agnostic TumoR-Anchoring Chimeras (MATRACs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Cancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity compared to traditional therapies. However, despite significant progress, current immunotherapies face limitations, particularly in targCancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity compared to traditional therapies. However, despite significant progress, current immunotherapies face limitations, particularly in targeting tumors without identifiable antigenic signatures and avoiding immune-related adverse events. In my ERC project I will explore an innovative approach utilizing Marker-Agnostic TumoR-Anchoring Chimera (MATRAC) technology, designed to harness the universal acidic microenvironment of solid tumors for targeted delivery of immune-modulating therapies. MATRACs are engineered recombinant fusion proteins that combine a therapeutic payload with a pH-responsive anchoring mechanism, ensuring selective activation in acidic tumor sites while minimizing off-target effects. Preliminary studies demonstrate MATRACs' enhanced tumor localization, pH-selective membrane binding, and potent immune-stimulating effects, laying the groundwork for their development as a versatile platform for innate immune-mediated cytotoxicity, cytokine therapy, and T-cell engagement in various cancer models. This research aims to optimize MATRACs' therapeutic efficacy and safety, with comprehensive preclinical evaluations including pharmacokinetics, immunogenicity, and toxicity assessments. By addressing critical gaps in current cancer immunotherapy, MATRAC technology holds the potential to expand treatment options for a broader range of patients, particularly those with antigenically challenging tumors, while improving the precision and effectiveness of immune-based therapies.

Keywords: tumor targeting,fusion proteins,tumor acidosis,immunotherapy