Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Holographic eXtended Reality (HXR) for true Augmented Reality (AR) and lifelike immersive displays (HXR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Challenge: Emerging semiconductor or quantum technology components (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-04-30
Duration (months): 26.0
Total project cost (EUR): 3563750.0
EU funding (EUR): 2494625.0
Participants: 1
Project status: SIGNED

Lifelike 3D images (holograms) have the potential to revolutionize key sectors, such as manufacturing, healthcare, consumer electronics, and creative industries. However, it has not yet been possible to create usable holographic displays for commercial applications due to the low visual quality of digital holograms and the very limited field of view of holographic projections. Swave is developing HXR, the world’s first spatial light modulator specifically designed for digital holography. Our proprietary technology will be commercialized as a novel chipset with supporting systems and algorithms, capable of generating and displaying high-fidelity dynamic holographic imagery. HXR will enable display manufacturers to create immersive, ultra-high resolution holographic displays, disrupting visualization markets forecast to grow to >€100bn by 2030. Swave is a spin-off from IMEC, leveraging 12+ years of research and a team with 100+ years of experience in bringing semiconductor/imaging products to market.

Keywords: augmented reality,3d visualization,phase change materials,digital holography,computer generated holograms,immersive displays
The first real-time monitoring and non-invasive medical device for personalised brain damage prevention during cardiac surgery (BrainProtect)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Lithuania
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Over 2M Cardiopulmonary bypass (CPB) surgeries are carried out each year globally. Up to 83% of CPB surgeries result in neurological complications such as delirium and post-operative cognitive dysfunction (POCD) which significantly contribute to increased morbidity, disability, decreased quality of life and mortality rates up to 33% after 1 year. Only 45% of patients fully recover from neurological complications after 1 year post cardiac surgery, and in many cases severe brain damage is irreversible. Economic burden is huge amounting to €8.4B direct costs/year in the EU & US. Monitoring Cerebral blood flow autoregulation (CA) and maintaining adequate patient specific brain perfusion during CPB surgery is critical to prevent neurological injury. However, none of the current technologies is capable to identify cerebral blood flow autoregulation impairments before the neurons die within 4-5 minutes. This calls for the need for advanced solutions to protect patients’ brain and optimize neurological outcomes during CPB. ScienceForBrain has developed BrainProtect, a patented, novel periodic rectangular modulation of blood flow during CPB, making it possible for the first time to monitor CA transient functions almost in real- time and to identify start and finish moments of brain insults in individual patient with only 15-30 second delay. This enables targeted interventions to restore optimal personalised brain perfusion and protect the brain during CPB surgery. BrainProtect has the potential to reduce the risk of POCD and delirium by at least 50%, saving lives, improving QoL for patients and reducing €231M annually in direct healthcare costs. BrainProtect is currently at TRL6, we obtained excellent preliminary results in clinical trials with 173 patients, and we now need support from the EIC to perform a multi-centred, double-blinded, clinical trial including 300 patients in the EU to get regulatory approval and successfully launch BrainProtect in the market by 2027.

Keywords: cardiopulmonary bypass cpb,brain damage,post operative cognitive disorder pocd,delirium,cardiovascular diseases,cardiac surgeries,heart and lung machine,cerebral flow auto regulation
Development of advanced manufacturing equipment and processes aimed at the seamless integration of multifunctional PV solutions, enabling the deployment of IPV sectors (SEAMLESS-PV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Belgium,Italy,Switzerland,France,Netherlands
Call: Advanced manufacturing of Integrated PV (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 16115512.47
EU funding (EUR): 12582309.31
Participants: 28
Project status: SIGNED

Beyond building-integrated photovoltaics (BIPV), slowly but steadily gaining adoption and settling as a more mature, recognized and reliable technology, the increasing interest of IPV solutions has recently started to expand towards other market segments. A curious gaze at our nearest environment allows identifying endless opportunities in which the implementation of IPV solutions could be addressed, bringing synergies, innovation and added value to important market segments such as infrastructures, transport, agriculture, urban environment, low-power electronic devices, etc. This idyllic approach brings, nevertheless, important challenges in the manufacturing, product development and effective integration of these multifunctional PV devices over final applications due to the fundamentally different specifications coming from each sector, which hinders the offer of a ‘one-fits-all’ technological approach. In addition, customization and flexibility in design is still constrained by existing manufacturing capacity and sophistication degree, which is, as of today, very much oriented towards more standardized manufacturing processes based on traditional PV equipment and processes. In this context, SEAMLESS-PV is conceived to answer this challenge by addressing (1) the development of advanced flexible automated PV equipment manufacturing based on high efficiency c-Si technologies, (2) the upscale of new manufacturing processes presenting key features (e.g. lightness, enhanced integrability) and cost reductions that enable the seamless integration of PV over final applications and (3) the development of a set of IPV products demonstrating cost-competitiveness and compliance with market requirements and expectations. The project will demonstrate this new manufacturing capacity at pilot level and showcase the opportunity for European IPV manufacturers and end-users to unleash the potential of this sector.

Keywords: advanced manufacturing integrated photovoltaic ipv bipv iipv vipv agri lightweight
INteroperable Tools for nEtwork-aware, Ledger-based Local energy sharIng and flexibility manaGEment leveraging user engagemeNT (INTELLIGENT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Germany,Serbia,Austria,Ireland,Switzerland,France,Belgium,Portugal,Italy,Brazil
Call: Creation of a standardised and open-source peer-to-peer energy sharing platform architecture for the energy sector (HORIZON-CL5-2023-D3-03, 2023)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 5962647.5
EU funding (EUR): 4999422.5
Participants: 17
Project status: SIGNED

To reach net-zero emissions by 2050, annual clean energy deployment needs to triple by 2030. Two major challenges hinder progress: grid operators lack the tools to manage distributed energy resources effectively, and citizens are not equipped to effectively participate in energy markets, particularly in peer-to-peer trading, which would foster individual investment in DERs. While the EU has established a legal framework for energy communities, its implementation has been restrictive, leading to energy communities based on predetermined, community-level prices and effectively peer-to-market rather than true P2P trading. The INTELLIGENT project will provide advanced P2P technology and demonstrate its benefits in 4 diverse EU communities to encourage regulators in EU member states to empower more advanced local energy sharing and trading. INTELLIGENT’s comprehensive P2P trading infrastructure includes interoperable decentralised energy exchange components, secure data exchange, and optimised trading and flexibility management for citizens and grid operators. These tools will be open source and protocol and regulation-agnostic, customisable for specific market requirements.The project leverages and extends the capabilities of the GSY DEX, an open-source P2P exchange software, which employs blockchain technology to enable grid-aware, secure, and automated exchange while fully accounting for network constraints. Innovations centres on a bottom-up, asset-based energy market design with sophisticated, AI/ML and blockchain-powered trading and flexibility mechanisms, supported by dynamic grid fee models and interoperability with grid operators, asset management and other related services. . INTELLIGENT's goal is to advance P2P energy trading technology, making it more accessible, secure, and efficient to optimise the economic and environmental benefits for citizens, while supporting grid operators to better address grid stability and congestion management.

Keywords: peer to peer trading,standards,open source,optimisation,energy market
Microgel technology for preservation of cultural heritage (MICROTECH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This PoC proposal is dedicated to the development of a new soft matter technology for paper preservation. Building on the recent ERC grant of the PI, MIMIC, that was mainly a theoretical and numerical effort on “Modelling microgels” in close synergy with experiments, MICROTECH proposes to exploit this fascinating class of soft colloids in a new application for cultural heritage. Microgels are colloidal-scale polymer networks, whose properties intrinsically depend on those of the constituent polymers. While most studies deal with thermoresponsive ones, here we propose to use gellan gum, a widely used biopolymer, since gellan gum hydrogels have been previously used to treat paper artifacts. We recently showed the use of gellan gum microgels is more advantageous with respect to hydrogels both in terms of efficacy and of application time. The proposed technology is ground-breaking because it will significantly reduce the economic costs of the treatment, it is environmentally friendly and also versatile. Indeed, we will functionalize the gellan macromolecule in order to optimize the specific interactions with the different nature of the surfaces to be treated. The main objectives of the interdisciplinary MICROTECH project will be to optimize the preparation, the functionalization and the long-time conservation of the microgels; to validate the technology on real samples, thanks to the collaborations with interested companies, who already expressed their Letters of Support; to perform a pre-commercialization study in terms of IPR and market analysis; to create of network of potential partners and users; finally, to deliver a ready-to-use microgel formulation and a business plan. Therefore, at the completion of the project, we expect that the technology will be available to potential end users.
Explicit methods for rational points on curves and their Jacobians (ExplicitRatPoints)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: CLOSED

The theory of rational points on curves and their Jacobians is distinguished by being both attractive and notoriously difficult. Despite major theoretical advances, explicit methods are of particular importance in this area. For instance, the conjecture of Birch and Swinnerton-Dyer (BSD), one of the Millennium Prize problems, was formulated based on numerical evidence. A proof of the strong version of this conjecture for abelian varieties seems out of reach at present, and even the verification in examples was, until recently, only possible in dimension 1. Besides being interesting in its own right, the importance of explicit methods for the computation of the rational points on curves stems from the fact that many moduli problems can be reduced to such computations. Therefore, explicit methods can be used to solve theoretical problems, but in the other direction, theoretical advances often lead to improved explicit methods. One example is the recent computation of the rational points on the "cursed curve" X_ns^+(13) using the quadratic Chabauty (QC) method, an explicit special case of Kim's non-abelian Chabauty program. We propose two research projects, connected by height theory, to significantly advance the state of the art in explicit methods for rational points on curves and Jacobians. In the first one, we will develop an explicit theory of heights to compute Mordell-Weil groups of Jacobians of non-hyperelliptic curves of genus 3. We will use it for the verification of the strong BSD conjecture for modular examples, going beyond the hyperelliptic case for the first time. In the second one, we will drastically increase the applicability of the QC method by removing several restrictive conditions, and apply it to Atkin-Lehner quotients of modular and Shimura curves, thereby solving several open moduli problems.

Keywords: computational arithmetic geometry,explicit methods,rational points on curves and their jacobians,birch swinnerton dyer conjecture,quadratic chabauty,non abelian chabauty,modular curves
IBISBA - Delivering the Infrastructure As a Legal Structure (IBISBA-DIALS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: France,Greece,Italy,Finland,Ireland,Belgium,Netherlands
Call: Early phase implementation of ESFRI Projects which entered the ESFRI Roadmap in 2018 (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1498641.11
EU funding (EUR): 1498641.11
Participants: 8
Project status: SIGNED

IBISBA is a European research infrastructure (RI) project included on the ESFRI roadmap. Its mission is to deliver a range of R&D services, contributing to the development of industrial biotechnology as a key enabling technology of smart, circular economy. So far IBISBA has benefitted from two Horizon 2020 projects, one providing preparatory phase funding. Following on from the preparatory phase (which entered its final year in 2023), the IBISBA-DIALS project aims to complete preparatory work, create and launch IBISBA as a European Research Infrastructure Consortium. During IBISBA-DIALS work required to submit compliant statutes will lead to the creation by the European Commission of the IBISBA-ERIC legal entity. Results will ensure that the entity is well structured and sustainable, possessing a central HQ and solid national nodes located in several EU members states. IBISBA-DIALS will also confer the future RI with vital tools and procedures, securing operational status immediately after its creation. Moreover, the project will provide IBISBA-ERIC with a committed stakeholder base, the potential to expand into new European or associate countries, and international visibility. Finally, IBISBA-DIALS will reinforce IBISBA’s scientific and technology excellence, while embedding its activities in a framework of responsible research and innovation and developing its role as an essential component of education in industrial biotechnology. Work in IBISBA-DIALS will be performed by a core group of project partners representing the most committed EU member countries. However, all work will be performed in close cooperation with a wider group of IBISBA stakeholders bound by a memorandum of understanding. In the medium-term standpoint, IBISBA-DIALS will provide the European RI landscape with a new landmark RI that uniquely produces translational research services in the fields of industrial biotechnology, thus supporting the development of smart biomanufacturing.

Keywords: industrial biotechnology synthetic biology translational research research infrastructure eric
Serotonin at the epigenetic nexus of tumorigenesis in Epstein Barr lymphoma (SENTINEL study)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 268568.64
EU funding (EUR): 268568.64
Participants: 2
Project status: SIGNED

The rising global incidence of Epstein-Barr virus (EBV)-related cancers highlights the urgent need to explore the mechanisms driving their pathogenesis. Many of these tumours are highly aggressive, with poor patient outcomes. The viral latent membrane protein-1 (LMP1) drives oncogenesis through poorly understood epigenetic mechanisms. Serotonin, which influences viral replication, has recently been linked to the regulation of gene expression in cancers via serotonylation, a newly discovered histone modification. However, whether serotonylation influences LMP1-driven oncogenesis remains unknown. Cancer-altered tryptophan metabolism reduces serotonin levels, partly through the recruitment of indoleamine 2,3-dioxygenase-1 (IDO1)-expressing macrophages that promote cancer progression, but it is unclear if viral factors are involved in their recruitment. Additionally, EBV binds to platelets, the body's richest serotonin source, though the significance of this interaction is also unknown. SENTINEL will adopt an interdisciplinary approach, integrating virology, epigenetics, immunology, and platelet biology to shed new insights into EBV driven cancer development. The fellowship comprises three research objectives (work packages WP1-3): WP1 will identify cellular and viral genes influenced by serotonylation, WP2 will examine EBV’s role in recruiting IDO1+ macrophages, and WP3 will investigate how platelets and platelet-derived serotonin regulate EBV’s life cycle. This research is a collaboration between leading experts in virology, epigenetics, immunology, and cancer biology, providing the Postdoctoral Fellow with a unique set of training opportunities in preparation for an independent research career. In uncovering novel tumorigenic mechanisms, the project is expected to pave the way for the development of new targeted therapies that could improve patient outcomes.

Keywords: epstein barr virus,lymphoma,platelet,serotonin,histone serotonylation,carcinogenesis
Realised ecological niche and species distributions under global environmental change (RELOAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Species are readjusting their geographical distributions as a response to ongoing environmental change. Thus, predicting species distributions is an urgent conservation endeavour. However, the responses of a species to the environment may vary in space and time (i.e. niche change) as the result of the spatiotemporal context of where and when its different populations occur. Niche changes are expected to have important consequences: (i) they can invalidate niche-based species distribution models, as a widely used predictive conservation tool, due to the limited spatiotemporal context of the underlying species distribution data, and (ii) they can impact the performance of species (e.g. their conservation status and extinction risk) that become decoupled from their optimal environmental conditions. However, we still poorly understand how the magnitude of niche change varies among species, especially within their native distributions and over relatively short time spans under ongoing global change. I will study how and why the magnitude of niche change varies among bird species. More specifically, I will examine how species functional traits and rates of global change within the species' geographical ranges affect the magnitude of niche change, and how niche change may impact the conservation status of species. The ultimate goal is to produce a global synthesis of spatial and temporal niche change to understand the general propensity of bird species to change their realised ecological niches. The project will contribute to estimate species-wise uncertainty of species distribution models and refine their predictions based on species' ecological traits.

Keywords: niche,species distributions,global change,traits,birds
Analysis of the volatile organic compounds emitted by extracellular vesicles for disease diagnosis (VOLATEVS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Estonia,Italy,Romania,Panama,Malaysia,Sweden
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 1077057.14
EU funding (EUR): 1025800.0
Participants: 9
Project status: SIGNED

This project aims at investigating the potential of analysing the volatile organic compounds emitted by extracellular vesicles as an innovative approach for disease diagnostic. Extracellular vesicles will be isolated from different biological samples, such as cancer cells, serum, urine and faeces. The volatile organic compounds emitted by the extracellular vesicles will be analysed employing several techniques, which will include gas chromatography coupled to mass spectrometry, vibrational spectroscopy and electronic nose systems. The results obtained in this project will ultimately allow assessing if the volatile organic compounds emitted by extracellular vesicles can provide additional information for disease diagnosis complementing the analysis of the biological samples from which they are extracted.

Keywords: extracellular vesicles volatile organic compounds gas chromatography mass spectrometry infrared spectroscopy electronic nose disease diagnosis