Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools (CRISPR2.0)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2025-10-31
Duration (months): 78.0
Total project cost (EUR): 1996525.0
EU funding (EUR): 1996525.0
Participants: 1
Project status: SIGNED

The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technologies suffer from drawbacks that limit their efficacy and versatility, necessitating the search for additional exploitable molecular activities. Building on our recent structural and biochemical studies, the goal of this project is to investigate the molecular architectures and mechanisms of CRISPR-associated systems and other genome defence mechanisms, aiming not only to shed light on their biological roles but also inform their technological development. Specifically, the proposed studies will examine (i) the molecular basis of cyclic oligoadenylate signalling in type III CRISPR-Cas systems, (ii) the mechanism of transposon-associated type I CRISPR-Cas systems and their putative function in RNA-guided DNA transposition, and (iii) molecular activities associated with recently described non-CRISPR defence systems. Collectively, the proposed studies will advance our understanding of the molecular functions of genome defence mechanisms in shaping the evolution of prokaryotic genomes and make critical contributions to their development as novel genetic engineering tools.

Keywords: crispr cas,transposons,nucleases,dna helicases,genome editing
The Netherlands Center for Multiscale Catalytic Energy Conversion (MCEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 3348480.0
EU funding (EUR): 1674240.0
Participants: 1
Project status: SIGNED

In the Netherlands Center for Multiscale Catalytic Energy Conversion (MCEC), teams of chemists, physicists and engineers from the universities of Utrecht, Eindhoven and Twente join forces in an ambitious research and training programme to address one of society’s Grand Challenges: sustainable energy conversion. Marie Curie funding allows MCEC to extend its PhD programme internationally with 16 positions for Early-Stage Researchers and to strengthen its multidisciplinary training programme in accordance with the EU principles of innovative doctoral training. MCEC’s objectives are: • Develop radically improved, sustainable catalytic energy conversion processes, for efficiently converting renewable feedstocks, such as biomass, municipal waste and solar energy, into fuels and chemical building blocks; • Establish a training programme that integrates the chemistry, physics and engineering aspects of energy conversion and jump-starts the career of young researchers by giving them the skills and competences needed to effectively operate in multidisciplinary teams; • Recruit the best researchers world-wide for an innovative programme of training-through-research in Multiscale Catalytic Energy Conversion with high quality supervision, a unique multidisciplinary training programme, transferable skills training and meaningful interaction with international and industrial partners, leading to a joint PhD degree; • Establish the MCEC PhD programme as a benchmark for effective multidisciplinary training among the three core partners and their partners ensuring continuation of the programme after the initial funding phase. In two open calls MCEC will attract the most talented researchers and select the best candidates through a fair, transparent, merit-based and impartial selection procedure. MCEC will deliver a cohort of research professionals equipped with the knowledge and skills needed to address the energy challenge in all sectors: academia, industry and governance.

Keywords: energy conversion,catalysis,chemical reactor engineering,physics of fluids,soft condensed matter,nano and microfluidics,multiscale modeling and theory
Integrating genetic, archaeological and historical perspectives on Eastern Central Europe, 400-900 CE (HistoGenes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Austria,Germany,Germany,Germany,Hungary,United States
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-05-01
End date: 2026-04-30
Duration (months): 72.0
Total project cost (EUR): 10041574.0
EU funding (EUR): 9996574.0
Participants: 12
Project status: SIGNED

Few parts of Europe witnessed so many population shifts in a few centuries as the Carpathian Basin in 400-900 CE. In this macro-region along the middle Danube, Pannonians, Romans, Goths, Gepids, Longobards, Avars, Bulgars, Slavs, Franks and many others came and went. This is an intriguing test case for the relationship between ethnic identities constructed in texts, cultural habitus attested in the archaeological record, and genetic profiles that can now be analysed through ancient DNA. What was the impact of migrations and mobility on the population of the Carpathian Basin? Was the late antique population replaced, did it mix with the newcomers, or did its descendants only adopt new cultural styles? To what degree did biological distinctions correspond to the cultural boundaries and/or ethnonyms in the texts? If pursued with methodological caution, this case study will have implications beyond the field. HistoGenes will analyse c. 6,000 samples from graves with cutting edge scientific methods, and contextualize the interpretation of these data in their archaeological and historical setting. The rapid progress of aDNA analysis and of bio-informatics now make such an enterprise viable. However, the methods of historical interpretation have not kept pace. HistoGenes will, for the first time, unite historians, archaeologists, geneticist, anthropologists, and specialists in bio-informatics, isotope analysis and other scientific methods. Many team members have already collaborated successfully in a pilot project, which has demonstrated the feasibility of the approach and of the integrated workflow at the core of the project. A wide range of particular historical questions will be addressed from an interdisciplinary perspective, and fundamental theoretical and methodological issues can be explored. HistoGenes will not only advance our knowledge about a key period in European history, but also establish new standards for the historical interpretation of genetic data.

Keywords: early middle ages,late antiquity,migration,ethnicity,transformation of the roman world,historical method,interdisciplinary method,steppe empires
Helping our customers to design smart and safe tomorrows’ communication systems (EDITUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

5G communication will use new system architectures and technologies which will considerably increase the transmission speed of Wireless Radio-Frequency (RF) and Microwave Wave (MW) communications (20x faster than 4G) paving the path for new opportunities. AMCAD ENGINEERING develops a new software platform to address this new telecommunication paradigm. This solution will help electronic manufacturers to save money and speed-up development cycle. The market of Electronic Design Automation (EDA) is $460M in 2019 with a projected CAGR of 12% during the forecast period (2018 - 2023).

Keywords: software for 5g telecommunication design and simulation
Quasi-local observables in quantum gravity (QLO-QG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

While a full theory of quantum gravity remains yet elusive, one can still make quantum-gravitational predictions by treating gravity perturbatively around a fixed classical background. This approach is particularly important in cosmology, where tree-level predictions have been confirmed in observations, and next-generation experiments measuring the 21-cm hydrogen line are very likely sensitive enough to test loop corrections. The objective of this proposal is the study of correlation functions at fixed geodesic distance. These observables possess two desirable properties: a) they are confined to a region of finite physical size, and thus measurable, so that one can test the predictions of any theory of quantum gravity against them; and b) they are gauge-invariant, and thus can be used to separate physical effects from gauge artefacts in many gauge-fixed loop calculations that have been carried out in cosmology. The main open problem about these observables is how to renormalise them, which has not been solved even at the one-loop order in perturbation theory. To solve this problem, we apply ideas from the study of Wilson loops in non-Abelian gauge theories, the only other nonlocal observable in quantum field theory which has been investigated in detail. Since these observables are also potentially important in AdS/CFT correspondence, we study them for all maximally symmetric spaces, i.e. Minkowski, de Sitter as well as anti-de Sitter spaces.
Reversibly photocrosslinked BIO-based composites with barrier properties from industrial by-products (ComBIOsites)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-09-15
Duration (months): 25.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

ComBIOsites aims at developing recyclable composite materials for packaging, using (i) raw materials issued from bio-based industrial by-products, according to the principles of circular economy, (ii) environmentally friendly processes, such as photopolymerization. This project is fully aligned with the European primary goals for the promotion of a “green” society, with a sustainable and resource efficient economy, by key actions such as the development of new and improved materials with reduced environmental impact, from sourcing and processing to end of life. Cellulose is an abundant, renewable and sustainable biopolymer, plus it is biodegradable. Microfibrillated cellulose (MFC), obtained with top-down approaches from cellulose sources, forms excellent gas barrier films ; however, their high hydrophilicity prevents their use in highly humid environments. It is therefore convenient to combine MFC with polymers in the form of composites. Crosslinked matrices guarantee high mechanical performances and water and solvent resistance. The uncured prepolymers can have very low viscosity, which allows for solvent-free mixing at room temperature. However curing often hinders recyclability. Reversible photocrosslinking of bio-based prepolymers, combined with MFC to obtain recyclable composites is innovative. To fulfil the final goal of the project, I will use MFC obtained from hemp hurd, a low cost by-product of industrial hemp decortication process, and a bio-based prepolymer, functionalized with a reversibly photocrosslinkable group, able to ensure the curing of the polymeric matrix upon irradiation at a given wavelength, and to allow its dismantling upon irradiation at a different wavelength. Thus, through appropriate matrix-filler combination and processing, I plan to obtain a reversibly photocrosslinked composite material having the performances requested for packaging, the recyclability of thermoplastics and potentially the biodegradability of natural polymers.

Keywords: bio composites,photopolymerization,reversible photocrosslinking,cellulose fibers,permeability
Rapid quality assessment of wood-based materials through spectroscopy (WoodSpec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

The European concern about climate change and greenhouse gas emissions has led to the promotion of clean energies. Considering the size of the waste wood market, the efficient utilization and the most appropriate exploitation of these materials could be a driver for climate change mitigation. In fact, it is well known that the reuse and recycle of waste materials is to be preferred to landfill. The wood materials could potentially be exploited in the panel industry to produce composites - such as panels - or they could be used for energy purposes instead of disposing them off. This project will develop a rapid tool based on spectroscopic techniques for the discrimination among the different types of wood-based materials – defining accordingly the most suitable target of use – and for assessing the chemical-physical characteristics (e.g. ash content, moisture content and calorific value) of the wood materials prior to be intended for energy purposes. The project takes an interdisciplinary approach involving a combination of analytical chemistry, chemometrics, spectroscopic techniques and wood science and it combines my research experience on wood sector with the host expertise in spectroscopic and chemometric techniques. The project will lead to important breakthroughs in the wood and wood-energy sectors since the expected results will support and valorize the wood-based materials in the optic of green economy and sustainable development. The project will enhance collaboration among scientific and non-scientific world promoting the application of the research. In addition, it will open up new collaborations thanks to the possibility to apply multivariate data analysis in different sectors beyond that of wood (i.e. food or waste). This project will be carried at Chemometrics and Analytical Technology Section of University of Copenhagen and at Biomass Lab of Università Politecnica delle Marche during a secondment.

Keywords: wood based materials,biofuels quality,wood characterization,green economy,circular economy
oPtimized zero-defect high-tech AuTomatic WRAPping machine (PAT WRAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

By blending the real and the virtual worlds of industrial production via the internet, the IoT connects all “actors” involved in the production process: machines, products, systems and people. Industry 4.0 will transform the manufacturing process through the self-optimization of production flow, a fully integrated and automatic process, highly flexibilized mass-production, self-diagnosis and intelligent support of workers. In this context, PAT WRAP aims at developing a secure and reliable high-tech automatic wrapping machine based on an innovative IoT platform. During the Phase1 project, the techno-economic feasibility of PAT WRAP will be assessed in order to support the forthcoming Phase2, for its industrialization and business exploitation. The innovative IoT platform, integrated in a re-designed automatic wrapping machine, will ensure higher productivity, onsite and remote monitoring of the whole machine and of the single components, safety process both for machine and operators, energy consumptions and waste reduction. The main result of PAT WRAP will be a reliable, scalable, flexible and customizable wrapping process, which allows to improve the manufacturing process with a reduction of the environmental impact up to 25%. The technology has already reached TRL6 and the Phase1 project aims at establish a robust industrialization and operational plan, at identifying stakeholders, sales channel and strategic partnership, at strengthening the business model with an in-depth market analysis, sound marketing strategy and reliable financial projections. The PAT WRAP project will represent a key opportunity for PIERI S.r.l., with the aim to be the first in Europe to introduce an innovative wrapping process integrated with an advanced IoT platform. This process will provide a clear impact on the Company business, affecting turnover (+40%), new employees hiring and a cash flow of around 1.002.540€ with an average ROI of 30% in the first 5 years of commercialization.

Keywords: predictive maintenance,vision system,quality control,affordable and flexible solution,sustainable solution,advanced wrapping machine
Modeling approaches toward bioinspired dynamic materials (DYNAPOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy,Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1999623.0
EU funding (EUR): 1999623.0
Participants: 2
Project status: SIGNED

Nature uses self-assembly to build fascinating supramolecular materials, such as microtubules and protein filaments, that can self-heal, reconfigure, adapt or respond to specific stimuli in dynamic way. Building synthetic (polymeric) supramolecular materials possessing similar bioinspired properties via the same self-assembly principles is interesting for many applications. But their rational design requires a detailed comprehension of the molecular determinants controlling the assembly (structure, dynamics and properties) that is typically very difficult to reach experimentally. The aim of this project is to obtain structure-dynamics-property relationships to learn how to control the dynamic bioinspired properties of supramolecular polymers. I propose to unravel the molecular origin of the bioinspired behavior through massive multiscale modeling, advanced simulations and machine learning. First, we will develop ad hoc molecular models to study monomer assembly and the supramolecular structure of various types of self-assembled materials on multiple scales. Second, using advanced simulation approaches we will characterize the supramolecular dynamics of these materials (dynamic exchange of monomers) at high (submolecular) resolution. We will then study bioinspired properties such as the ability of various supramolecular materials to self-heal, adapt or reconfigure dynamically in response to specific stimuli. Our models will be systematically validated by comparison with the experimental evidence from our collaborators. Finally, we will use machine learning approaches to analyze our high-resolution simulations and to identify the key monomer features that control and determine the structure, dynamics and dynamic properties of a supramolecular material (i.e., structure-dynamics-property relationships). This research will produce unprecedented insight and fundamental models for the rational design of artificial dynamic materials with controllable bioinspired properties.

Keywords: molecular simulation,multiscale modeling,self assembly,bioinspired,dynamic materials,supramolecular polymer,coarse graining,structure property relationships,responsive,adaptive materials