Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications (MACUMBA)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,France,Ireland,Iceland,Spain,Ireland,United Kingdom,Denmark,Italy,France,United Kingdom,Germany,Spain,Germany,Germany,France,Germany,Belgium,Portugal,Austria
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 11970227.6
EU funding (EUR): 8999948.0
Participants: 25
Project status: CLOSED

Marine microorganisms form an almost untapped resource of biotechnological potential. However, its use is hindered by the low success rate of isolation of novel microorganisms and often by poor growth efficiency. Hence, the vast majority of marine microorganisms has not been cultivated and is often considered as ‘unculturable’. MaCuMBA aims at improving the isolation rate and growth efficiency of marine microorganisms from conventional and extreme habitats, by applying innovative methods, and the use of automated high throughput procedures. The approaches include the co-cultivation of interdependent microorganisms, as well as gradient cultures and other methods mimicking the natural environment, and the exploitation of cell-to-cell communication. Signaling molecules produced by microorganisms may be necessary for stimulating growth of the same or other species, or may prevent their growth. Signaling molecules also represent an interesting and marketable product. MaCuMBA will make use of high throughput platforms such Cocagne, using gel micro-droplet technology, or MicroDish in which many thousands of cultures are grown simultaneously. Various single-cell isolation methods, such as optical tweezers, will aid the isolation of specific target cells. Isolated microorganisms as well as their genomes will be screened for a wide range of bioactive products and other properties of biotechnological interest, such as genetic transformability. Growth efficiency and expression of ‘silent’ genes of selected strains will be increased also by using the clues obtained from genomic information. MaCuMBA is targeted to SMEs and industry and they make a significant part of the consortium, ensuring that the project focuses on the interests of these partners. Moreover, MaCuMBA has adopted a comprehensive and professional exploitation, dissemination, implementation, and education strategy, ensuring that MaCuMBA’s results and products will be directed to end-users and stakeholders.

Keywords: bioactive compounds,biotechnology,cell-to-cell communication,cultivation efficiency,extreme environments,high throughput methods,natural substrates,marine ecosystems,marine microorganisms
Strengthening Technology, Research and Innovation Cooperation between Europe and South Africa (ESASTAP PLUS)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Bilateral coordination for the enhancement and development of S&T Partnerships
Action type: Coordination and support actions
Countries involved: Greece,South Africa,Italy,Germany,France,Switzerland,Greece
Call:  (FP7-INCO-2012-2, 2012)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 1798876.63
EU funding (EUR): 1497009.0
Participants: 9
Project status: CLOSED

The European Union and South Africa have long been committed to strategic cooperation in science and technology, dating back to their 1996 Cooperation Agreement, which facilitated cooperation under the Framework Programmes. South Africa has also concluded several bilateral cooperation agreements with EU Member States. South Africa is aiming to create a robust national system of innovation to enable its transition to a knowledge economy, achieving sustained growth and development. On the other hand, the Innovation Union Flagship Initiative provides a new innovation policy context for the EU with an emphasis on addressing global societal challenges, increasing European competitiveness, and attracting research talents and investments to Europe. South Africa and the EU, thus, share similar objectives and there is rich potential for cooperation in innovation to complement their substantial trade, innovation and development cooperation. Building on the work of earlier BILAT actions, ESASTAP PLUS will support the deepening of scientific and technological cooperation with a special focus on innovation. This will achieved by supporting South Africa’s participation in the Framework Programmes, but also reciprocal European participation in South African programmes. Specific input will be provided to enrich the bilateral policy dialogue, notably to identify priority areas for mutually beneficial cooperation. A major focus will be to target coordination of Member States and Associated Countries' research policies and programmes vis-à-vis South Africa, encouraging the development of new joint initiatives implemented by several countries. Synergy between different EU cooperation initiatives will also be encouraged, e.g. between development cooperation and research programmes. All activities will be undertaken to ensure sustainable impact, including ownership of initiatives by stakeholders.

Keywords: enhancing the sa-eu sti cooperation,eu and ms&ac bilateral cooperation,innovation for enhanced cooperation,supporting policy dialogue
Knowledge Based Bio-based Products' Pre-Standardization (KBBPPS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,United Kingdom,Germany,Belgium,Netherlands,Greece
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-08-01
End date: 2015-07-31
Duration (months): 36.0
Total project cost (EUR): 3852826.6
EU funding (EUR): 2994223.0
Participants: 7
Project status: CLOSED

The application of standards and certification systems in the European bio-based product industry has positive long-term effects on the overall development of bio-based product markets. Trade barriers are reduced and the development of a pan-European market for bio-based products is promoted. Finally, public acceptance of bio-based products is increased through ensuring and verifying the sustainable sourcing of raw materials, the effective bio-content and clear indication of their (comparative) functionality in relation to the regular products. The KBBPPS project aims at increasing the uptake speed of standards and certification systems for bio-based products. This project covers research and demonstration on bio-based carbon content determination, biomass content methods not solely dependent on 14C-analysis and biodegradability and eco-toxicity test schemes. Next, identification and resolution of functionality related bottlenecks with the view to developing, harmonising and validating test methodologies will be undertaken. The possibilities for improving sample preparation, fractionation and thermal treatments will be studied in order to cover bio-base carbon and other bio-based elements determination. Next, practical solutions for stakeholders, lab and field tests on biodegradation or biological derived elements will be investigated. The goal in the end is that the results can be copied one-to-one into European standards. Following Mandates by the EC, the European Standardization Committee initiated a Technical Committee, CEN/TC 411. on "Bio-based products". By participating in this committee (its Secretariat being one of the partners), by exchanging with ASTM and ISO, and by doing pre- and co-normative research for them, KBBPPS will allow the European stakeholders to progress with well-defined, sound test methods correlated to actual field behaviour and applicability in the lab.

Keywords: standard,cen,bio-solvent,bio-plastic,bio-lubricants,bio-surfactant,functionality,biodegradability,bio-based product,biomass content,bio-based carbon
Parasite risk assesment with integrated tools in EU fish production value chains (PARASITE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Spain,Italy,France,Spain,Faroe Islands,Viet Nam,China,Philippines,Germany,Denmark,Croatia,United Kingdom,Norway,Germany,Netherlands
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2016-01-31
Duration (months): 36.0
Total project cost (EUR): 5107293.6
EU funding (EUR): 3986295.0
Participants: 21
Project status: CLOSED

Despite many efforts to ensure that only high-quality and safe products are put on the market, fish-borne parasites continue to pose risks to human health, with zoonotic infections and allergic reactions mainly following consumption of raw, lightly cooked, or marinated seafood. The PARASITE proposal is presented by a multidisciplinary consortium of 12 European and 3 Asian research institutions and 6 European SMEs. It aims to provide new scientific evidence and technological developments to detect, monitor, and mitigate impacts of zoonotic parasites, mainly anisakid nematodes but also trematode metacercariae, occurring in European and imported fishery products. The Project will address the research needs identified by EFSA regarding the risk of seafood-borne parasites. It also will facilitate close cooperation between scientists and end-users to produce new technological solutions and management tools for both European and imported fishery products. The Work Plan has been organized in 9 work packages, each covering different stages of a risk assessment framework, providing new epidemiological data, monitoring tools, development and implementation of parasite detection devices, technological tools for their mitigation, and dissemination of key results to all the stakeholders and the general public. Risk assessment of zoonotic parasites will ensure significant progress beyond the state of the art. This will be achieved by improving molecular hazard identification, antigen/allergen characterization, parasite exposure assessment, detection methods and treatments for industrial and other end-users, and an integrated quantitative risk analysis based on powerful statistics and modelling, The main results will impact by (1) contributing to enhanced seafood safety, with consequent benefits for public health and consumer confidence, (2) strengthening the competitiveness of European seafood, from the net to the plate and (3) improving EU food safety policies.

Keywords: food safety,quality. parasite,seafood,risk analysis,detection methods
Development of Personalised Food using Rapid Manufacturing for the Nutrition of elderly Consumers (PERFORMANCE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Germany,Netherlands,Germany,Denmark,Italy,Austria,Netherlands,Netherlands,Germany,Germany,Netherlands
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 4025146.5
EU funding (EUR): 2997886.0
Participants: 14
Project status: CLOSED

The main idea of the PERFORMANCE project is to develop and validate a holistic, personalized food supply chain for frail elderly in nursing homes, ambient assisted living facilities or at home (served by nursing services). The supply “chain” in this case will resemble a loop with the elderly consumers forming the initial link (personal preference and needs) and final link (consumption). As a result PERFORMANCE project, an overall concept will be available which allows the automatic manufacturing and supply of personalized, specially textured food for frail elderly. To answer these questions, the PERFORMANCE concept will cover the whole supply chain from the food producer to the ready-to eat-meal at consumer’s place (both in nursing facilities and at home). Focus will be put on personalized food for people with mastication and swallowing problems (i.e. not only elderly). This group presents 5% of the elderly and has special texture requirements for the food preparation. Elderly in general require careful consideration of various determinants of their nutritional and health status. In contrast to younger people, the impact of nutrition on their well-being and health status is way higher in elderly. The nutritional status of elderly is influenced not only through the aging process, the health status (physiological and physical disabilities) but also through psychological (e.g. the way food is prepared), social-economic factors (available income). Therefore, the PERFORMANCE project will mean a great step forward to improve the Quality of Life of the elderly by offering them a complete new personalised nutritional concept able to increase their independency, health status and social life.

Keywords: food printing,elderly,supply chain logistics
Optimisation of early reproductive success in dairy cattle through the definition of new traits and improved reproductive biotechnology (FECUND)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Italy,Germany,France,Ireland,Austria,Poland,Italy,Netherlands,Italy,Germany,Ireland,Poland
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 3912649.3
EU funding (EUR): 2999393.0
Participants: 13
Project status: CLOSED

Good fertility is essential for the sustainability of livestock production. Of all livestock sectors, fertility of dairy cattle is raising the greatest cause for concern. Cow fertility has declined, particularly in Holstein cattle, from 80% pregnancy to first service 20 years ago to less than 40% today. Poor fertility is one of the main reasons for early culling, such that modern dairy cows complete fewer than 3 lactations, on average. The FECUND project will address the metabolic and genetic causes of low reproductive success of dairy cows in an interdisciplinary approach that will integrate in vivo and in vitro studies, biology, physiology, -omics technologies and bioinformatics. FECUND will focus on the early phases of reproduction from oocyte development to implantation of the conceptus. Starting from biological materials produced from high and low genetic merit cattle and from cows under energy stress of early lactation vs dry cows and heifers, FECUND will study, independently, the effects of genetics and metabolic stress on reproductive physiology to identify factors and early markers associated with high and low developmental potential, and with positive mother-conceptus interaction during the early stages of reproduction. These data will be mined to reveal physiological pathways and key candidate genes controlling variations of fertility. The biological knowledge created on early reproductive events in vivo will be validated in vitro, and extended to create further knowledge on the effects of the local environment on oocyte and embryo programming at the epigenetic level. Validated information will be used to improve herd management, gene assisted and genomic selection and assisted reproductive technologies, from in vitro ooctye maturation to optimised embryo culture. Information on biomarkers, indicator traits and improvements in assisted reproduction will be translated to applications that can be immediately implemented by SMEs.

Keywords: dairy cattle reproduction,metabolism,genetics,follicle,oocyte,oviduct,embryo,conceptus,uterus,novel traits,biomarkers,novel genetic markers,reproductive biotechnologies,in vitro protocols
The Industrial Biotech Research and Innovation Platforms Centre - towards Technological Innovation and solid foundations for a growing industrial biotech sector in Europe (BIO-TIC)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Coordination and support actions
Countries involved: Belgium,United Kingdom,Netherlands,Germany,Germany,France,Finland,Italy,Belgium
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-08-01
End date: 2015-07-31
Duration (months): 36.0
Total project cost (EUR): 2809777.6
EU funding (EUR): 1995798.0
Participants: 13
Project status: CLOSED

The project goal is to draw-up a blueprint document of recommendations for overcoming the innovation hurdles within a selection of targeted business market segments that can make a major contribution to an accelerated take-up of industrial biotechnology (IB) into the market place. This will involve: - Analysis of existing knowledge bank relating to market, research and institutional barriers hindering uptake of IB technology innovations into the market place - Engagement with a broad range of stakeholders across the full multidisciplinary IB spectrum to update, develop and validate these innovation barriers to market entry - Formulation of a roadmap of action plans and policy recommendations for accelerated uptake of IB into a number of targeted product segment areas Bio-TIC will compile an in-depth preparation of three “interim roadmaps” comprising market projections, R&D priorities and non-technological barriers to IB market entry. These will act to guide and facilitate a series of convened stakeholder workshops at both national and European level for a full discussion on innovation barriers, in order to validate and further elaborate more comprehensive roadmaps, while taking on board the totality of views from the diverse IB stakeholder base. Finally, the partners will collate and further refine the developed roadmaps into a joint European IB Roadmap and Policy recommendations document, with maximum stakeholder buy-in for wide dissemination and maximum impact. The project will be co-ordinated by EuropaBio- the European Association for Biotechnology Industries, who will also be joined by CEFIC, the European Chemical Industry Council, representing the European chemical industry. These will be joined in the consortium by a further 9 members incorporating innovation agencies, cluster organisations and private management consultancies; all of whom have many complementary skills and expertise and who have worked together in the past on similar initiatives.

Keywords: industrial biotechnology,innovation hurdles,biomass feedstock,multiple stakeholders,roadmaps,r&d priorities,market projections,non-technological barriers
Increasing Value and Flow in the Marine Biodiscovery Pipeline (PHARMASEA)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Belgium,United Kingdom,Norway,Spain,Ireland,Italy,Italy,Spain,United Kingdom,Germany,Denmark,China,South Africa,Switzerland,New Zealand,United Kingdom,Belgium,Germany,United Kingdom,United Kingdom,Chile,Costa Rica,Austria
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-10-01
End date: 2017-03-31
Duration (months): 54.0
Total project cost (EUR): 13194699.8
EU funding (EUR): 9465907.0
Participants: 25
Project status: CLOSED

The PharmaSea project focuses on obstacles in marine biodiscovery research, development and commercialization and brings together a broad interdisciplinary team of academic and industry researchers and specialists to address and overcome these. The partners are ideally placed to demonstrate how to widen the bottlenecks and increase the flow of ideas and products derived from the marine microbiome towards a greater number of successes in a larger number of application areas. Despite the tremendous potential of marine biodiscovery, exploitation, particularly at a commercial scale, has been hampered by a number of constraints. These relate to access (physical and legal), genetics of the organisms, compound isolation, structure elucidation, early reliable validation of biological activity and best mechanisms of flow-through into exploitation. PharmaSea will solve these chronic bottlenecks by developing essential actions beyond the state of the art and linking them with best practice and appropriate pragmatic approaches. The robust pipeline structure established within PharmaSea will process a wide genetic basis including marine microbial strain collections held by partners and new strain collections from extreme environments (deep, cold and hot vent habitats) to produce new products with desirable characteristics for development by the SME partners in three accessible market sectors, health (infection, inflammation, CNS diseases), personal care and nutrition. The global aim of PharmaSea is to produce two compounds at larger scale and advance them to pre-clinical evaluation. To address relevant challenges in marine biodiscovery related to policy and legal issues, PharmaSea will bring together practitioners, legal experts, policy advisors/makers and other stakeholders, focusing on the feasibility of harmonising, aligning and complementing current legal frameworks with recommendations and ready to use solutions tailored to marine biodiscovery.

Keywords: marine biodiscovery,marine biodiversity,bacteria,actinobacteria,fungi,metagenomics,genome scanning,biosynthesis,structure determination,nuclear magnetic resonance spectroscopy,mass spectrome
Innovative Method and Procedure to Assess Counter-violent-radicalisation Techniques in Europe (IMPACT EUROPE)

Framework: FP7 — Cooperation
Programme: Security
Destination: Security and society
Action type: Collaborative project
Countries involved: Netherlands,France,United Kingdom,Poland,Italy,Netherlands,Belgium,Israel,Netherlands,United Kingdom,Germany,Denmark
Call:  (FP7-SEC-2012-1, 2012)
Start date: 2014-01-01
End date: 2017-06-30
Duration (months): 42.0
Total project cost (EUR): 3522328.38
EU funding (EUR): 2801537.1
Participants: 15
Project status: CLOSED

IMPACT Europe will develop an evaluation toolkit to help professionals in the public and voluntary sectors design and implement an evaluation of their programmes tackling violent radicalisation, whether policies or interventions. The toolkit will also help professionals go beyond the evaluation of a single project by integrating promising practice into the design and implementation of future programmes. This evaluation toolkit will be composed of four elements: 1) A standardised methodology, to provide professionals with a tool to conduct robust evaluations; 2) An evaluation results database, to allow professionals to analyse these results over time, identify promising practice and develop a more informed understanding of violent radicalisation; 3) A training course (including a train-the-trainer component), to build professionals’ capacity to design, carry out and learn from appropriate evaluations; 4) A training manual, to provide easy reference for professionals applying the toolkit.

Keywords: evaluation methodology assessment toolkit radicalisation interventions extremism terrorism policy programme