Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Implementation of CRISPR/Cas9 technology in melon to edit fruit ripening and CMV resistant genes (MeloCRISP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-15
End date: 2021-03-28
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Meeting with global food demand is one of the main priorities in the 2016-17 work programme of H2020. Virus diseases are among the main causes of crop production losses, being Cucumber mosaic virus (CMV) the virus with broadest host range. On the other hand, post-harvest losses are estimated to account for 15-40% of fruit and vegetable production worldwide. In this scenario, several efforts are ongoing to identify genes underlying fruit quality and production such us those related with climacteric ripening and CMV resistance Melon (Cucumis melo L.) is one oft he most economically important group of vegetable crops after Solanaceae, and has emerged as a crop model for important biological traits due to its phenotypic variability and the the availability of genetic and genomic resources. Previous studies at the host group have identified and mapped genes involved in the regulation of climacteric fruit ripening and in a novel mechanism for CMV resistance in this species. MeloCRISP proposes to progress our current understanding on the genomic control of these important agronomic traits by functionally validating the identified candidate genes. The CRISPR/Cas9 system will be implemented for the first time in this species and used for precise gene editing. In order to delay or impair fruit ripening in climacteric varieties, a gene knockout strategy will be approached. On the other hand, a precise nucleotide substitution in the resistance to CMV region (cmv1) will be performed to generate CMV resistant plants The expected outcome is the development of non-transgenic melon CMV resistant plants and varieties with improved fruit quality. This inter-sectorial and multidisciplinary project involves the engagement of a seed industry which will guarantee the transfer of the results to the seed market, ultimately leading to a high impact in the agriculture and food industry sector. Moreover, the implementation of CRISPR/Cas9 will become a valuable tool for melon breeding programs.

Keywords: virus resistance,climacteric fruit ripening,melon,crispr,cas9,mutant
Road Diplomacy: International Infrastructure and Ethnography of Geopolitics in 21st Century Asia (Road Diplomacy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The objective of this project is to understand where, why, and to what extent roads are being built between China and South Asia and to untangle the inter-related geopolitical and social impacts of infrastructure development at village, national, and international scales. The project will first map road developments throughout the trans-Himalaya and second investigate the geopolitical drivers and social impacts of road construction. By combining innovative methods from geography, anthropology, and international relations, I will produce new empirical data on infrastructure development in 21st century Asia and illustrate the links between macro geopolitical processes and micro local experiences. Datasets will improve interdisciplinary communications for social scientists and between development practitioners, donor agencies, policymakers, and local stakeholders. The research is of relevance to EU citizens because understanding contemporary dynamics between rising powers like China and India provides context on 21st century global politics and will inform decision-making for EU investment and development interventions in Asia.

Keywords: development,infrastructure,mobility,geopolitics,himalaya,china,india,nepal
Hydrogen-Aeolic Energy with Optimised eLectrolysers Upstream of Substation (Haeolus)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Spain,Norway,Norway,Norway,Belgium,France,France
Call: Highly flexible electrolysers balancing the energy output inside the fence of a wind park (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 7779761.25
EU funding (EUR): 4997738.630000001
Participants: 18
Project status: SIGNED

The Haeolus project will install a 2.5 MW electrolyser in the remote region of Varanger, Norway, inside the Raggovidda wind farm, whose growth is limited by grid bottlenecks. The electrolyser will be based on PEM technology and will be integrated with the wind farm, hydrogen storage and a smaller fuel cell for re-electrification. To maximise relevance to wind farms across the EU and the world, the plant will be operated in multiple emulated configurations (energy storage, mini-grid, fuel production). Like many large wind farms, especially offshore, Raggovidda is difficult to access, in particular in winter: Haeolus will therefore deploy a remote monitoring and control system allowing the system to operate without personnel on site. Maintenance requirements will be minimised by a specially developed diagnostic and prognostic system for the electrolyser and BoP systems. The containerised electrolyser is a standard model carried by project partner Hydrogenics. The integrated system will be housed in a specially erected hall to protect it from the Arctic winter and allow year-round access. The integrated system of electrolyser, fuel cells, and wind farm will be designed for flexibility in demonstration, to allow emulating different operating modes and grid services. Haeolus answers the AWP's challenge with the widest possible project scope, with operation modes not limited to the site's particular needs but extended to all major use cases, and several in-depth analyses (released as public reports) on the business case of electrolysers in wind farms, their impact on energy systems and the environment, and their applicability in a wide range of conditions.

Keywords: wind grid remote
Development of a new first-principle Framework for Quantum Thermoelectricity — Application to 2D materials (QTherm-2D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-15
End date: 2020-12-29
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The development of sustainable energy sources poses one of the greatest challenges for our society nowadays. The current increase in energy demands across the world makes fossil-fuel based energy resources unsustainable. Research and Innovation on finding, developing and enhancing green energy sources are crucial to achieve the EU aim to obtain 20% of its energy from renewable sources by 2020. Thermoelectric (TE) energy conversion is one alternative to produce green renewable energy by converting heat into electrical energy. However, the efficiency of current TE technology is poor and limiting its usage. Entering the nanoscale, promises to overcome the problem of low efficiency but require also novel theories describing correctly TE phenomena at the quantum level. This Marie Słodowska-Curie action, called “Development of a new first-principle Framework for Quantum Thermoelectricity — Application to 2D materials” (QTherm-2D), aims at exploring and advancing the emergence of thermoelectricity at the nanoscale, where quantum effects dominate. QTherm-2D will overcome the limitations of the state-of-the-art methods and go beyond by developing a novel transport theory for the investigation of TE energy conversion in realistic nanodevices. This will provide a theoretical framework capable of making groundbreaking predictions for high-efficient TE devices and heat-dissipating materials. This original formalism will then be applied together with state-of-the-art methods to address fundamental issues related to the emergence of quantum thermoelectricity and to explore 2D materials for TE applications. Based on this understanding, potential hybrid devices will be designed by heterostructuring of different 2D materials. The action is designed to outperform current TE technologies and might help overcoming one of the most important challenges humanity is facing nowadays.

Keywords: thermoelectricity,2d materials,td dft,non equilibrium thermodynamics
Contributing to a well-reasoned set of Airworthiness Standards for mass-market drones (AW-Drones)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Israel,Germany,Italy,Cyprus,Greece,Belgium,France,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Airworthiness of mass-market drones (H2020-MG-2018-SingleStage-INEA, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 2628153.75
EU funding (EUR): 2628153.25
Participants: 13
Project status: CLOSED

The AW-Drones Coordination and Support Action intends to contribute to the safe use of mass market drones by facilitating the on-going EU regulatory process for the definition of rules, technical standards and procedures. The Action will benefit from the contribution of the most relevant stakeholders in the drone value-chain including drone suppliers, operators, academia and regulators. These actors will support, from their respective point of view, the collection of data, information and perspectives regarding the use of drones worldwide and contribute to its analysis supporting EASA's regulatory due-process. In particular, data, information and perspectives will include: · Current standardization activity and standard perspectives for evolution of drone products and services · Research works regarding safety and incidents involving drones · Local and regional solutions adopted by aviation safety regulators to address mass market drone operations · Application issues emerging from different market application of drones · Elements hampering wide distribution and mutual recognition of drone-based product and services between States Information gathered will be critically assessed and benchmarked using defined criteria taking into account the needs and opinions of the different stakeholders of the drone value-chain. Data useful for the validation of specific products or technical requirements will be structured systematically and correlated with appropriate confidence measures. The objectives will be to: · Provide a knowledge-base of "best practice" and data supporting the EASA's regulatory process · Contribute to the development and subsequent validation of a well-reasoned set of technical standards appropriate for all relevant categories of drones

Keywords: airworthiness,mass market
SYNergies for Cohorts in Health: integrating the ROle of all Stakeholders (SYNCHROS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Spain,Spain,Spain,Belgium,Norway,Switzerland,Poland,France,France
Call: Building international efforts on population and patient cohorts (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 1991812.5
EU funding (EUR): 1991812.5
Participants: 14
Project status: CLOSED

SYNCHROS (SYNergies for Cohorts in Health: integrating the ROle of all Stakeholders) coordination and support action aims to establish a sustainable European strategy for the development of the next generation of integrated population, patient and clinical trial cohorts, thereby contributing to an international strategic agenda for enhanced coordination of cohorts globally. This will address the practical, ethical and legal, and the methodological challenge to optimising the exploitation of current and future cohort data, towards the development of stratified and personalised medicine as well as facilitating health policy. In order to achieve this objective, SYNCHROS will map the cohort landscape in Europe and large international initiatives, identify the best methods for integrating cohort data, identify solutions for addressing practical, ethical and legal challenges in integrating data across patient, clinical trial and population cohorts, and evaluate the use of emerging and new data collection technologies and types of data. Together with intensive stakeholder involvement (researchers, patients, funding bodies, clinicians, coordinators of previous harmonization and integration exercises), strategy briefs will be written and used to conduct stakeholder dialogues to generate consensus following a deliberative process and implementation science methods. We aim to make sustainable recommendations on standards to improve future sample, data collection and data sharing methods and disseminate this information so as to contribute to defining an international strategic agenda for better coordination of cohorts globally. SYNCHROS partners include a large range of expertise from epidemiology and clinical research to legal/ethical issues and anthropology, international organizations such as WHO and European infrastructures such as ECRIN.

Keywords: cohort,epidemiology,prospective,harmonization,integration,database,patients,funding bodies,clinical trial,patient
Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behavior (DimorphicCircuits)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

In sexually reproducing species, males and females respond to environmental sensory cues and transform the input into sexually dimorphic traits. These dimorphisms are the basis for sex-biased phenotypes in many neurological diseases. Yet, complete understanding of the underlying mechanism is still missing. How does the sexual identity impose molecular changes to individual neurons and circuits? What are the sex-specific synaptic changes that occur during development in these circuits? We recently demonstrated a sexually dimorphic dimension of neuronal connectivity: neurons belonging to a shared nervous system rewire in a sex-specific manner to generate sexually dimorphic behaviors. New findings from our lab further reveal a significant difference in the way the two sexes in the nematode C. elegans respond to aversive stimuli. These dimorphic responses are mediated via sex-shared circuits that receive similar environmental input, yet respond differently. Building on our exciting preliminary results, we seek to elucidate how genetic sex modulates neuronal function, neural circuit dynamics and behavior during development. This proposal will pursue three complementary objectives: (i) Map the repertoire of sexually dimorphic avoidance behaviors; (ii) Study the synaptic basis for the development of sexually dimorphic circuits; and (iii) Elucidate the molecular basis of sexually dimorphic neuronal circuits. These mechanisms can only be currently resolved in C. elegans, where the entire connectome of the nervous system for both sexes has been mapped. Using cutting-edge optogenetics, calcium imaging, activity-dependent trans-synaptic labeling, genetic screens and single-cell transcriptome analysis we will shed light on the elusive connection between genes, circuits and behavior. Understanding how genetic sex modulates neuronal circuits will aid in the development of novel gender-specific therapies.

Keywords: sex specific connectivity,neuronal circuits,caenorhabditis elegans,dimorphic behaviors,sexual selection,dimorphism,trans synaptic labeling,single cell rna seq,connectome,nociception
Cognitive Empowerment Resulting in Environmental Sustainability Improvement (CERES+). Human-Machine interaction in Industrial Vehicles through an innovative Augmented Reality System. (CERES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cognitive Empowerment Resulting in Environmental Sustainability Improvement (CERES+). Vehicles used in industrial applications, such as in agriculture, forestry, construction (or earth moving), and mining, are increasingly empowered by digital information (i.e., sensors) in their production. This evolution has many benefits but there might also be negative side effects. Operation of industrial vehicles can be related with cognitive challenges and high mental load. For example, already today the working situation of a forestry harvester operator has been compared to that of a fighter pilot. Optea has developed the first high Field Of View (FOV) Head Up Display’s (HUD’s) that supports augmented reality, for forestry and agriculture. Blending system information with the real world, which enhance situational awareness of operators on the field without unduly exert their vision and cognitive power or forcing them in unnatural positions. Optea system is the only HUD 'plug and play' system already tested in relevant field capable of solving several specific applications needed in the targeted off-highway vehicle markets Optea HUD will in fact 1) allow for a higher vehicle productivity, 2) lower threshold for new drivers (including young workforce and women), 3) increase safety, 4) offer ergonomic improvements, 5) lower fuel consumption derived from smarter vehicle operation. According to a study by Global Information Inc. , the global off-highway vehicle market is expected to register a CAGR of 7.79% between 2018 and 2023 and will reach a market size of over 35 B€ by 2020. Optea is gearing up to capture the leading position as provider of HUD systems in Europe by 2023. The CERES+ SME Phase 1 project will study the feasibility for commercialization and commodification of the Optea technology into sellable products for the off-highway vehicle market.

Keywords: augmented reality,head up display,human machine interaction,cognitive,digital,farming,precision farming,big data,productivity
Enabling MULTI-FUNctional performance through multi-material additive manufacturing (MULTI-FUN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Austria,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Austria,Austria,Austria,Austria,Spain,Austria,Belgium,Switzerland,Poland,United Kingdom,Portugal,United Kingdom
Call: Advanced materials for additive manufacturing (IA) (H2020-NMBP-TR-IND-2019, 2019)
Start date: 2020-03-01
End date: 2023-12-31
Duration (months): 46.0
Total project cost (EUR): 9235953.75
EU funding (EUR): 7891666.51
Participants: 22
Project status: SIGNED

MULTI-FUN sets a clear focus on market-creating innovation, developing advanced materials and equipment for Additive Manufacturing of multi-material parts. These new material combinations will provide a significant performance & efficiency gain in MAM products by fully integrated multi-functionalities based on novel active materials and enable MULTI-MATERIAL design in geometrically complex 3D metal parts without size limitations by innovative, cost-effective AM technologies. The novel integrated functionalities include embedded electrical conductivity, fibre-optical sensing features or innovative heat management concepts, incl. applying nanotechnologies in at least 3 variants. Leading experts in AM process & equipment manufacturing (from SMEs, IND, RTOs and UNIV) will fully cover the physical integration of these advanced materials into metallic substrates. Significant improvements in efficiency, quality & reliability of products will result in KPI numbers beyond the request (>40%), alongside reduced environmental impact as well as lower costs also much better than the given number of >35%. The evaluation assessment (reg. general performance & quality of novel functionalities) and LCA will be performed on 7 industrial demonstrators, addressing structural parts, moulds and test equipment for aerospace, automotive and general industrial usage. By wide usage of cost-effective wire & arc-based AM systems, complemented by efficient powder processing methods (esp. thin multi-material features), market uptake will be benefited, esp. for SMEs. MULTI-FUN includes 9 EU SMEs as key players in advanced materials research for AM, providing a great opportunity to accelerate market uptake. Stakeholder involvement (e.g. reg. Certification & Standardization) will foster business models & marketing of strong USPs of MULTI-FUN.

Keywords: advanced materials and equipment for additive manufacturing,nanoparticles,multi material parts,novel integrated multi functionalities,reduced environmental impact,market uptake by sme le