Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Stratified Therapeutic Assessment Platform for Short Telomere related Lung Fibrosis using Patient-Derived iPSC (STAR-TEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1499420.0
EU funding (EUR): 1499420.0
Participants: 1
Project status: SIGNED

Idiopathic pulmonary fibrosis (IPF) is a lethal scarring lung disease often leading to death within 3 years of diagnosis. New antifibrotic medications slow disease progression but they are poorly tolerated by patients. Telomeres, protective structures or caps at the ends of chromosomes, governed by the enzyme telomerase are shortened in type 2 alveolar epithelial cells (AT2)s in sporadic IPF but particularly so in inherited mutations of telomere related genes causing severe disease with early onset. Early clinical studies indicate that danazol modulates telomere length and prevents the progression of pulmonary fibrosis but it is poorly tolerated by patients, causing liver toxicity. Gene therapies including mRNAs which target telomerase have potential but human preclinical models do not exist to test their efficacy. Thus, a new human preclinical model is required to better understand pathogenesis and find new treatments. In preliminary work, I demonstrate that AT2 cells generated from patient-iPSC (iAT2) can replicate elements of pulmonary fibrosis pathogenesis and that telomere length in these cells undergoes heterogenous shortening over time, analogous to the shortening which occurs in vivo. Based on this data and previously published mouse studies, I hypothesise that telomere shortening in AT2 cells causes senescence, DNA damage and inflammation in both sporadic and inherited forms of IPF. Furthermore, I hypothesise that specific gene stratified mRNA-nanomedicines delivered to the lung can modulate telomere length in a precise manner avoiding toxicity. I will compare iAT2 and hepatic cells generated from patients recruited to a clinical trial of danazol to their own clinical outcomes from the study, thereby performing the first ‘clinical trial in a dish’ in pulmonary fibrosis - to a) better understand the role of telomere shortening in IPF and to b) identify and test gene stratified mRNA-nanomedicines and delivery chemistries leading to improved patient survival.

Keywords: idiopathic pulmonary fibrosis,ipf,ipsc,telomeres,familial pulmonary fibrosis
Shared Heritage: Early Modern Colonial Forts in the South China Sea (SCS) bordering communities (SHARED_fort_Heritage)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Mexico
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-05-01
End date: 2026-10-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 3
Project status: SIGNED

Forts of the South China Sea bordering countries built between the sixteenth and nineteenth centuries are a notable remain of the long and complex history of encounters and exchanges with European powers. Practically forgotten by scholars and local administrations, it is time to enhance their value with a new discourse as a Shared Heritage between European and local communities. This project aims to: 1) show how the local practices in the South China Sea bordering countries mingled with the European theory of fortifications; 2) raise the value of the shared fort heritage to create joint forces to preserve it; 3) digitalize forts to make them publicly available as captured memory of current state. It is planned to begin with traditional methods of study, among which are: a historical analysis using archival documents and morphological analysis. Also, the TLS methods will be used for digitalization as it allows a continuous recording of objects with a high level of accuracy for further analysis and modeling. Then an entirely new interdisciplinary research methodology will be introduced, namely, the transcultural interpretation of shared heritage that involves HBIM, novel typomorphological analysis, finite element analysis (FEA), material analysis, and statistics. The main foreseen results are the change of societal views on colonial forts. The new shared view on the valuable structures and their digitalization for universal public access during centuries to come.

Keywords: bastion forts,southeast asia,europe,shared heritage,transcultural view
Cell-like Autonomy: An Autonomous Artificial Cell with Self-regulated Oscillation (Cell-like Autonomy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-05
End date: 2027-01-04
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

The living cell is an active system that can display autonomy by implementation of dissipative out-of-equilibrium and self-regulated oscillatory behaviours. Manifestation of these dynamic traits into artificial microcompartments (termed artificial cell or protocell) will advance the construction of “smart” artificial cells and the development of synthetic protobiology. Even though numerous reports have illustrated the feasibility of fuel-depleted out-of-equilibrium reactions/behaviors in artificial cells, implementation of more advanced self-regulated artificial cells capable of sustained cell-like dynamics and homeostasis is still very challenging due to the lacks of apparatus and strategy. The overall aim of this proposal is therefore to construct an autonomous artificial cell capable of self-regulated oscillation, which can be coupled to sustained out-of-equilibrium behaviors and environmental homeostasis by chemo-chemical/chemo-mechanical transition modes. Implementation of this proposed work will advance development of synthetic protobiology by producing “smart” protocells with cell-like autonomy. Coupling the self-regulated oscillations to other forms of out-of-equilibrium behaviors by chemo-chemical/chemo-mechanical transitions will further extend the significance of this work by offering a strategy to construct smart and adaptive materials (e.g., autonomous soft robotics) for engineering applications.

Keywords: artificial cell,cell like autonomy,self regulated oscillation,homeostasis,chemo chemical chemo mechanical signal transition,soft micro robiotics
Science in the City (SitC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Malta,Ireland
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 291764.88
EU funding (EUR): 291764.88
Participants: 3
Project status: SIGNED

This innovative and highly interactive festival seeks to create bridges between science, research, technology and the arts. It aims to attract Maltese and Europeans, from all walks of life. Engaging visitors with activities, performances, workshops, experiments, installations, exhibitions, talks, comedy, sports and so on. The Science in the City Malat Festival shines a spotlight on researchers, who work with the SitC team, artists and members of the community to create fun events for our audiences to better understand and enjoy the research. Besides showing adults, youths and children that STEAM is fun, exciting and offers great career opportunities for all interests, the festival emphasises how vital creatvity is to nurturing critical thinking skills. We aim to highlight the importance of looking to science and research to improve the world we live in by encouraging changemakers to look to knowledge and info about hte latest scientific developments to support their drive for change.

Keywords: european researchers night,science in the city,science and arts festival,science communication,public engagement with research
Hybrid electronic-photonic architectures for brain-inspired computing (HYBRAIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Switzerland,United Kingdom,Italy,Germany
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-05-01
End date: 2026-10-31
Duration (months): 54.0
Total project cost (EUR): 1672528.75
EU funding (EUR): 1672528.5
Participants: 6
Project status: SIGNED

As artificial intelligence (AI) proliferates, hardware systems that can perform inference at ultralow latency, high precision and low power are crucial and urgently required to deal – especially quasi-locally, i.e. ‘in the edge’ – with massive and heterogenous data, respond in real time and avoid unintended consequences and function in complex and often unpredictable environments. Conventional digital electronics and the associated computer architecture is unable to meet these stringent requirements with sub-ms latency inference and a sub-10W power budget, using convolution neural networks (CNNs) on benchmarks such as ImageNet classification. HYBRAIN’s vision is to realize a pathway for a radical new technology with ultrafast (~1 microsecond) and energy-efficient (~1 watt) edge AI inference based on a world-first, brain-inspired hybrid architecture of integrated photonics and unconventional electronics. The deeply entwined memory and processing like in the mammalian brain obviates the need to shuttle around synaptic weights. The most stringent latency bottleneck in CNNs is in the initial convolution layers. Our approach will take advantage of the ultrahigh throughput and low latency of photonic convolutional processors (PCPs) employing novel phase-change materials in these initial layers to radically speed up processing. Their output is processed using cascaded electronic linear and nonlinear classifier layers, based on memristive (phase-change memory) crossbar arrays and dopant network processing units, respectively. HYBRAIN’s science-towards-technology breakthrough brings together the world’s top research groups from academia and industry in complementary technology platforms. Each of these platforms is already highly promising, but by integrating them, HYBRAIN will have a transformative effect of overcoming existing barriers of latency and energy consumption and will enable a whole new spectrum of edge AI applications throughout society.

Keywords: physical substrate computing,in memory computing,brain inspired computing,neuromorphic computing,unconventional computing
Senolytics repurposing in childhood refractory epilepsies (EpiSen)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Epilepsy is a frequent neurological disorder characterized by recurrent seizures resulting from hyperexcitability and hypersynchrony of neuronal networks. Cortical malformations, including Focal Cortical Dysplasia (FCD), are rare sporadic diseases that cause early-life drug-resistant seizures for which surgery is the only therapeutic option to control seizures. Surgical inaccessibility and failures are significant clinical drawbacks. This emphasizes a critical and urgent need for new precision-based therapies for this debilitating childhood disorder. In recent years, my team contributed to revealing that FCD are caused by brain somatic mutations in genes belonging to the mTOR pathway, a signaling cascade regulating key physiological cell functions such as growth, proliferation, and metabolism. During the course of my ERC-funded project, we discovered specific biomarkers in both human and mouse preclinical FCD brain tissues. In EpiSen, we propose an innovative pharmacological strategy based on the selective elimination of mutated cells by repurposing available molecules, that are currently used in clinical trials in other diseases, for FCD-related epilepsy. We hypothesize that abnormal cells, once acutely cleared, will offer a prolonged benefit on seizures. Direct users include applied research groups, pharma companies, the medical community for clinical trials, and patient associations.
Phase Change Material in District Heating with Model Predictive Control (PaCeInDH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

Rapid escalation of building energy use has raised concerns all over the world, and existing predictions express that this increasing trend will aggravate energy crisis and serious environmental problem. The district heating (DH) system that incorporates renewables and the thermal energy storage component shows favorable prospects as a supplier to serve residential and commercial consumers for space heating and domestic hot water. The operation temperature of the DH system is becoming lower to achieve a more energy efficient, sustainable, and eco-efficient system. This trend results in the performance degradation of the thermal storage when integrating the water tank to the DH system, resulting in potential economic losses. Meanwhile, a large heat storage and released rate cannot be achieved for the water tank with the limited size under the low temperature operation conditions. Compared with sensible heat thermal energy storage, the latent heat thermal energy storage (LHTES) is advantaged by its use of phase-change materials (PCMs) with high energy storage density at a near-constant phase-change temperature. To enable an energy efficient low temperature DH system, an appropriate storage medium with great thermophysical properties and low cost will be selected. The technical viability and practical applicability of the entire heating system will be experimentally and numerically investigated. A hybrid agent-based model predictive control (MPC) framework will be further built as a promising solution to achieve an effective energy management for the low temperature DH combined LHTES system. It is projected that the energy and economic performance of the DH combined LHTES system could be guided by the agent-based MPC. The capability of the agent-based MPC for performance enhancement will be finally calibrated and evaluated, and high-quality experimental research will be conducted for the validation of this hybrid control method outputs.

Keywords: district heating system,latent heat thermal energy storage,phase change material,agent based model predictive control,energy and economic benefits,experimental and numerical
Optimised plant immune receptor pairs for improved disease resistance (CooPAIRation)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 1654408.0
EU funding (EUR): 1654408.0
Participants: 1
Project status: SIGNED

CooPAIRation is an ambitious project that aims to harness the genetic diversity and evolutionary history of the TaPik wheat immune receptor pair to determine the molecular mechanisms underpinning paired receptor compatibility and guide the design of optimised immune receptor pairs for disease resistance. Bioengineering new resistance profiles in plant immune receptors offers a powerful solution for the timely deployment of new disease resistance traits in the field to fight off rapidly evolving plant pathogens that threaten food security. However, bioengineering plant immune receptor pairs often leads to suboptimal immune responses, likely due to receptor incompatibility caused by the editing process. To address this, the central hypothesis of CooPAIRation is that identifying the mechanisms underlying paired immune receptor compatibility in the context of natural and bioengineered alleles will guide optimisation efforts to enable the deployment and stacking of immune receptor alleles without detrimental effects for crop plants. To achieve our aim, we will combine phylogenetics, functional assays and structural biology to link variation in the immune response across different immune receptor pairs to specific molecular determinants of receptor compatibility and harness this information to design optimised receptor pairs for disease resistance. We will pursue the following objectives: 1. Phylogenetics: Determine the variation in immune response triggered by coevolved and mismatched receptor pairs 2. Mechanisms: Identify the molecular mechanisms underlying sensor-helper compatibility 3. Biophysics: Define the biophysical properties of optimal and suboptimal sensor-helper combinations 4. Resistance: Deliver optimised receptor pairs for disease resistance At the completion of this project, we will define the underpinning functioning principles of paired immune receptor compatibility and deliver optimised strategies for bioengineering disease resistance.
OPerando analyses and modelling of INterface dynamics and CHARGE transport in lithium-ion batteries (OPINCHARGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Luxembourg,France,Spain,Germany,Netherlands,Slovakia,Switzerland
Call: Interface and electron monitoring for the engineering of new and emerging battery technologies (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 4996340.0
EU funding (EUR): 4996340.0
Participants: 12
Project status: SIGNED

Battery innovation has played a major role in the development of new energy production & transport technologies, becoming true enablers of a clean, affordable and secure energy economy. However, innovation is currently being hindered by the lack of understanding of the processes happening at atomic levels in the batteries' interfaces and interphases. Thus, the OPINCHARGE consortium aims to develop a set of effective operando nanoanalytical techniques and methodologies to understand the interfacial processes in batteries in unprecedented level of detail. For this, 10 organizations from 7 different countries will work together, combining their expertise and infrastructure, to find new ways of addressing this challenge. This will be fostered through 3 main pillars of technique innovation: chemical-based, isotope-based, and physics-based. Consequently, main techniques to be addressed operando will be: X-ray scattering, enhanced Raman, STEM-EELS & EDX, FIB-SIMS, Neutron imaging, OEMS and NMR. Parallelly, the consortium will integrate AI/Machine Learning support, in order to improve data acquisition and analysis, making the data crunching processes more efficient and meaningful. Likewise, data treatment and sharing are cornerstones of the project, as Open Science practices and scientific collaboration with the community are recognized by the consortium as key aspects of the BIG-MAP objectives of the Batteries partnership and 2030+ programmes. With a 36 month duration, the project is divided in 7 work packages distributed among the partners according to their expertise, with LIST as leader of the consortium. Dissemination, exploitation and communication activities will allow to maximize the impact of the results and the outreach of these, by actively promoting the diffusion of the information derived from the activities of the project.

Keywords: batteries,interface,interphase,lithium ion,transport,charge,modelling,operando,analytical tools