Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Intelligent Gearbox for Endurance Advanced Rotorcraft (iGear)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Portugal,United Kingdom
Call: Advanced Health Monitoring System for next generation materials (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-03-01
End date: 2021-05-31
Duration (months): 51.0
Total project cost (EUR): 471855.69
EU funding (EUR): 410044.13
Participants: 2
Project status: CLOSED

The ultimate goal of the iGear (Intelligent Gearbox for Endurance Advanced Rotorcraft) project is the development of an on-the-fly Structural Health Monitoring (SHM). This innovative system will be applied to the lateral rotor gearboxes and engine to main gearbox reduction stages, in the framework of LifeRCraft demonstrator for the Fast Rotorcraft IADP. This topic is of high importance in order to promote enabling technologies for next generation gearboxes comprising new materials, namely composite or ceramic. The primary objective of the iGear proposal is to assess technologies suitable to characterize health monitoring condition of gearboxes, mainly by enabling the provision of the localization and early detection of gearing and bearing failure. The ultimate goal is the early detection of on-going failures to allow for prompt maintenance or part replacement. This project inherits significant knowledge and developments made by Active Space Technologies and Cranfield University during former or ongoing research activities related to solutions performing in harsh environments, namely accelerometers, temperature detectors, and acoustic emission sensors. In this project we will need an innovative approach to the use of ceramic ball bearings for the high speed shaft. The combination of vibration, oil analysis, among other technologies, will be used for both the Lateral Rotor Gearboxes and the Engine to Main Gearbox reduction stages. The key innovation we propose is the use of data fusion across condition indicators (Cis) to increase the robustness of diagnosis. We will seek to avoid excessive computation while maintaining traceability to acceptable rule-based diagnosis and probability, e.g. by adopting fuzzy logic for signal fusion. We will also examine the effectiveness of a system oriented approach, seeking to understand the sensitivities around the health state transitions, which must be transmitted to the user rather than solely focussing on damage measurements.

Keywords: monitoring,harsh environment,sensors,ceramics,endurance,prediction to failure,health monitoring,acoustic emission,prognosis
The top quark crucible: Standard Model and beyond the Standard Model physics in top quark precision studies (TQCRCBL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

This proposal describes the exploration of properties of the top quark for the study of Standard Model physics and tests of physics beyond the Standard model. Research will be conducted starting from the data of 13 TeV run of the Large Hadron Collider with particular focus on the determination of the top quark mass and other observables that might be sensitive to subtle new physics, which hides in standard searches for new physics carried out at the Large Hadron Collider experiments, in particular searches that suffer from large systematic uncertainties in the sensitive regions of phase space.

Keywords: top quark,precision physics,new physics,large hadron collider
Assisting Coral Reef Survival in the Face of Climate Change (CORALASSIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-08-01
End date: 2022-09-30
Duration (months): 62.0
Total project cost (EUR): 2023119.0
EU funding (EUR): 2023119.0
Participants: 1
Project status: CLOSED

CORALASSIST spans the disciplines of evolutionary biology, restoration ecology and proteomics and examines the role assisted gene flow (AGF) can play in sustaining biodiversity and ecosystem services in the face of climate change. AGF involves the deliberate movement of individuals or gametes within their natural range to facilitate adaptation to environmental change. Corals reefs provide an excellent model for testing AGF as a conservation tool because reef building corals are foundation species and are highly vulnerable to thermal stress. Selective breeding and translocation of thermotolerant individuals may lead to reductions in recipient population fitness due to resource trade-offs with other fitness traits, such as growth and fecundity. The overall aim of CORALASSIST is to establish the feasibility of implementing AGF in coral reef ecosystems using a combination of selective breeding, proteomics and innovative translocation techniques. CORALASSIST will address four primary questions: 1) Are there resource trade-offs between increased thermotolerance and other fitness traits in corals? 2) Which physiological and proteomic traits correlate with increased individual thermotolerance in corals? 3) Are phenotypic traits for thermotolerance heritable? 4) Can AGF and selective breeding lead to persistent shifts in thermotolerance in recipient populations? Phenotypic traits will be measured in permanently tagged individuals within selected coral populations to examine the relationships between thermotolerance and key fitness attributes. For the first time, state of the art proteomic approaches will be used to elucidate the physiological basis for increased levels of thermotolerance in corals. Innovative translocation methods will be used in tandem with selective breeding techniques to carry out the first long term assessment of heritability of thermotolerance and to test the feasibility of large scale AGF to assist conservation of coral reef ecosystems.

Keywords: coral reef,ecological restoration,climate change,assisted gene flow
GSnapshots of tropical Pacific climate variability during the time of Lapita ocean voyaging: giant clam fossils from Fijian shell middens as high resolution archives of climate information. (REEFCLAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-07-01
End date: 2024-10-29
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Records of pre-industrial climate change are vital for accurately simulating Earth’s climate system and reducing uncertainty in 21st century climate predictions. Giant clams are particularly valuable archives of past climate as they are fast-growing, long-lived, and their dense shells have annual growth bands that can be subsampled and analysed to produce sub-annually resolved climate proxy records spanning multiple decades. Furthermore, they are common in the tropical Pacific, where paleoclimate data is particularly valued as sub-annual to decadal-scale changes in this region have been linked to dramatic global temperature and rainfall anomalies with far-reaching socioeconomic and environmental effects. Giant clams are/were a common food and tool supply in the tropical Pacific, and are abundant in Lapita-age shell middens, providing unique opportunities for paleoclimate research that have surprisingly not been exploited. In REEFCLAM, I will use giant clam shells in a ~3,000 year old shell midden to generate the first sub-annually resolved record of pre-industrial climate variability in Fiji. Specifically, trace element and stable isotope profiles across multiple shells will be generated and stitched together, and used to reconstruct patterns of variability in sea surface temperature and salinity. Fiji’s climate is highly sensitive to changes in the SPCZ and WPWP, and so these records will provide a snapshot of Mid-Late Holocene variability relating to the El Niño Southern Oscillation that will be of great value to the climate community. I will generate the first modern clam-based geochemical proxy calibrations for Fiji providing an important platform for future work. Importantly, the data will be also used to test the hypothesis that the pulse of eastward ocean voyaging by the Lapita people and their rapid colonisation of the Pacific coincided with more frequent El Niño events (more westerlies), a novel opportunity to marry the sciences and the humanities.

Keywords: paleoclimatology,paleoceanography,mollusca,trace elements,stable isotopes,lapita
Design and redesign of a plant immune receptor complex (ImmunityByPairDesign)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 2499978.0
EU funding (EUR): 1972649.0
Participants: 2
Project status: CLOSED

This project will (1) reveal design principles of paired immune receptor complexes and (2) elevate plant disease resistance by enabling design of immune receptors with new recognition capacities. Plant immunity is triggered upon pathogen detection by dedicated immune receptors. Like animal Nod-like receptors (NLRs), plant immune receptors have a modular structure and can work in pairs, both of which are required for defence activation upon recognition of specific pathogen proteins. How such intracellular immune receptor complexes activate defence solely upon recognition of microbial molecules is poorly understood. Using novel high risk/high gain methods such as domain/domain cross-linking with mass spectrometry (XL-MS) and cryo-electron microscopy, as well as X-ray crystallography, genetics and cell biology, we will define at a structural level the domain/domain interactions within an immune receptor complex, and how these change upon pathogen perception. The Arabidopsis RPS4/RRS1 immune receptor acts in the cell nucleus to detect when pathogen effectors target WRKY transcription factors, converting effector interactions with the RRS1 WRKY domain into defence activation via RPS4. We will reveal the intra-molecular reconfigurations required for signalling and thus tackle a problem of broad significance, both for immune receptors, and for other intracellular receptors that are activated by ligand-dependent release from negative regulation. We will also create and test derivatives of RPS4/RRS1 or related complexes that are designed to respond to effectors that target other host protein domains. As Richard Feynman said, “What I cannot create, I do not understand”. By designing immune receptors to recognize other pathogen effectors, we will test models of how plant immune receptors activate defence, but only upon effector recognition. This second objective is ambitious and high risk/high gain, but potentially game-changing for crop disease control.

Keywords: plant disease resistance,immune receptors,receptor biology,pathogens,pathogen effectors
Synthetic Mini-Chromosomes for Antibody Production (MiChomAbs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Ribbon Biolabs has developed a unique, patented technology for the synthesis of long DNA molecules. As a key product in development through this platform, the company is targeting at the development and production of small, chromosome-like synthetic modular genetic units - which we term MiChroms - for monoclonal antibody production. The production of therapeutic monoclonal antibodies (mAbs) relies on unstable cell-lines, making the availability of the products limited and very expensive for the end user. Introducing MiChroms to the production process will solve this problem by making production batches larger and lower consumer prices, increasing the affordability of breakthrough medicines to a larger patient population. The MiChroms are tailored to specific cell-lines and specific biopharmaceutical mAbs and are independent modular genetic components that, unlike recombinant engineered master cell-lines, do not interfere with the cell’s functioning. With this approach, we can increase cell-line stability and also cover the market needs. Moreover, the model is scalable because it is bound to reduce production costs, reduce price of the end product and increase supply and product portfolio, benefitting the end user. Our main target market is the development of new biologics, specifically monoclonal antibodies for therapeutics, but will also target biosimilars of the main blockbuster antibodies. We plan to sell our genetic design to companies producing and developing biosimilars, where our roles are: a) the design of the artificial chromosome that is suitable for specific mammalian cell lines (e.g. CHO cells) and b) genetic variants in terms of biopharmaceutical copy-number and post-translational variations. Ribbon Biolabs restricts itself to the production of the mini chromosomes but provides variants as required for the clients to determine the tailored sequence that best fits their lines and processes.

Keywords: monoclonal antibodies,biosimilars,synthetic dna,biologics
New Concrete-Towers Assembly system for taller Wind Turbines. (AIRCRANE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-03-01
End date: 2020-10-31
Duration (months): 32.0
Total project cost (EUR): 2125125.0
EU funding (EUR): 1487587.5
Participants: 1
Project status: CLOSED

Skyscrapers building technology marked a turning point in the construction sector: Due to the great heights of those buildings, the only way to build them is with a crane which rises in the manner the skyscraper does. Inspired by that idea, we developed the AIRCRANE SYSTEM. The wind energy sector currently has a main objective: decrease the Levelized Cost of produced Energy (LCoE), in order to be comparable to other energy sources in the coming years. The strategies to decrease are mainly concentrated in two action groups: Reduce the cost of wind turbines and capture as much energy as possible. Regarding the second group, manufacturers are convinced the best way is to create more powerful turbines (up to 8 MW) and install the nacelle and rotor at greater heights, where the wind blows harder and there are less turbulences. The market requires taller towers, supporting heavier loads on top as well. The only alternative, due to steel tower's limitations, is to make at least the lower part with concrete. But the concrete weak point is its weight, which requires the use of largest crawlers and cranes: very expensive machines and with a limited number of units worldwide. The AIRCRANE SYSTEM is a brand new technology that serves to assembly concrete wind-turbine towers, with theoretically infinite height: the Aircrane system is based on a external self-climbing crane which rises as the construction of the tower does, once its completed and built, the system will lift the nacelle and blades. There are two main advantages: (1) Radically reduce current construction costs in the tallest concrete towers, and additionally (2) open a new market-niche, being able to construct towers with no height limits. Successful project completion represents a significant business opportunity for our SME, with expected REVENUES of € 32,5/58,5 million within 5/7 years and the creation of 98/167 Direct Jobs, and 176/307 Indirect jobs

Keywords: wind,energy,crane,concrete,tower,construction
Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy (THERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Denmark
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-02-01
End date: 2021-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography – HPLC, mass spectrometry – MS) are exclusively used in central laboratories due to their cost, system size and weight, complexity of use and maintenance requirements. Second, alternative technologies (e.g. ELISA immunoassays) are analyte-specific and do not allow adaptability to new analytes (increasing costs). We verified the feasibility and clinical utility of using Surface Enhanced Raman Spectroscopy (SERS) for TDM using real plasma samples taken from de-identified patients. Importantly, our measurements were consistent with state-of-the-art data generated by LC-MS/MS. We already have experimentally shown a 0.1 μM detection limit on pure, artificial samples. Within THERA, we aim to transform our research output into a commercially-relevant (in terms of size, throughput, user friendliness and cost) product by creating a minimum viable product that will enable TDM for a wide variety of molecules. Our goal within this project is to validate this device on clinical samples and build a strong business case for it that will enable commercial exploitation. THERA will advance our SERS-based device from a current technology readiness level of 3 to 5/6. Our value proposition is a tabletop, miniaturized (smartphone-sized) device that can perform TDM on a single droplet of blood, in a matter of minutes, without the need for specialized personnel, at a fraction of the cost currently associated with TDM.

Keywords: therapeutic drug monitoring,surface enhanced raman spectroscopy,whole blood analysis
A revolutionary, cost effective, ultra-compact proton therapy system for cancer treatment (HIL PT System)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 2081250.0
EU funding (EUR): 1456875.0
Participants: 1
Project status: SUSPENDED

Cancer is a global problem with 14.1 million new cases occurring annually and an expected increase of 68% by 2030. Ensuring effective and safe treatment remains a significant challenge for healthcare organisations. Studies have shown Proton Therapy (PT) to be effective in treating many types of tumours, including tumours of the prostate, brain, head and neck, central nervous system, lung, and gastrointestinal system as well as cancers that cannot be removed completely by surgery. PT is the most advanced type of external-beam radiation therapy that uses protons at high energy to destroy cancer cells. It can be used alone or combined with other treatments e.g. radiation therapy, surgery, chemotherapy, and/or immunotherapy. PT is routinely used for cancer treatment, however it is limited by the sheer size and expense of the systems. There are currently only 102 operational PT facilities in the world, addressing less than 5% of clinical demand. HIL has developed an ultra-compact, high-performance system for Proton Therapy. HIL’s advanced particle accelerator and beamline technologies make PT widely accessible by offering highly cost-effective single-room solutions. During this complimentary blended finance project, HIL intends to develop and manufacture its pre-Beta system in Israel's first PT centre. In addition, the development of the Beta version of the system will be carried out, which will enable the company to launch its first sales and undertake additional crucial commercial activities, preparing the company for widespread market penetration.

Keywords: proton therapy,cancer treatment,nanotechnology,high intensity laser,spatial efficiency