Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design and construction of programmed protocells for intercellular networks and biomimetic communications (PROGRAMED PROTOCELLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Artificial cellular counterparts (protocells) can be fabricated to produce explicit biomimetic outcomes such as RNA-mediated replication, gene expression, metabolism, etc. These synthetic mimics with cell-like traits, aim to answer fundamental questions regarding origin of cellularity from non-living components. However, minimal levels of structural/organisational complexity exhibited in current protocell designs, limits their application potential. The aim of this proposal is to use bottom-up approaches to precisely design and construct complex protocells through membrane coupled appendages and produce interactive protocellular communities which will recognize, sort and processes chemical signals through collective behaviour. The self-assembled protocellular colonies will be sequestered with complex enzymatic reaction networks which operate spontaneously and synergistically reminiscent to living cells. Several important functions such as selective formation of protocellular consortia, mimicking important biological functions such as IDH-kinase/phosphatase (AceK) circuitry from the Krebs cycle, redox-homeostasis, self-protection from chemical degradation will increase the complexity of the protocellular constructs producing the first example of functional proto-colonies. The expertise of the applicant in the field of organic synthesis, supramolecular chemistry and out-of-equilibrium self-assembly will be employed by the multidisciplinary and evolving field of protocells pioneered by the hosting group of Professor Stephen Mann FRS at the University of Bristol. The combined research efforts of the applicant and the Mann group will result in the successful realization of programmable protocells resulting in active self-assembling protocellular constructs and build their advanced forms capable of spatio-temporal self-sorting, self-regulation and higher-order organization and function.
TOpological many-body states with ultracold RYDberg atoms (TORYD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1900000.0
EU funding (EUR): 1900000.0
Participants: 1
Project status: SIGNED

Understanding and controlling quantum matter is a key challenge for basic research and for the development of applications. The richness of quantum physics is notoriously difficult to handle for strong interactions, usually leading to massive entanglement between particles, especially when it is associated with a nontrivial topology of the Hamiltonian. The realization of well-controlled experiments probing strongly correlated quantum matter is thus a major objective to explore these perspectives. In this project, I will investigate many-body states of quantum matter in- and out-of-equilibrium. I will study the interplay between topology and interactions in tailored model systems and explore new quantum phases of matter. I will focus on two main objectives: (i) The study of dynamical properties of strongly interacting 1D Bose gases using quantum transport experiments. (ii) The realization of fractional Chern insulator states in topological lattices. These objectives will be achieved thanks to ultracold gases of Rydberg atoms, where the excellent control of quantum gases is extended thanks to the strong interactions between Rydberg particles.

Keywords: topology,rydberg atoms,bose einstein condensates,edge states,optical lattices
Enacting the Good Economy: Biocapitalization and the little tools of valuation (LITTLE TOOLS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-12-31
Duration (months): 64.0
Total project cost (EUR): 1495079.0
EU funding (EUR): 1495079.0
Participants: 1
Project status: CLOSED

What shall we live off in the future? Where will our food come from, and what will form the basis for our economies? A so-called “blue revolution”, where fish become farmed rather than caught, is increasingly presented as an answer to the above questions. This transformation of the economy exemplifies ongoing efforts to produce new forms of capital out of the ordering and reordering of life. These processes are intimately related to the expanding life sciences, the bioeconomy and what is sometimes called new forms of biocapital. But how do such large transformations take place in actual practice, and by which means? This project argues that if we are to understand such major transformations we need to study “little tools”, that is, material-semiotic entities that carefully modify and work upon bodies, markets and science. Emerging bioeconomies are expected not only to produce economic value but also to enact values in other ways that contribute to what this project refers to as “the good economy”. Such values include enabling sustainable fisheries, secure animal welfare or sustainable growth. The main hypothesis of the current project is that the enactment of the good economy can be studied by valuation practices performed by material-semiotic little tools. The project will explore this hypothesis at multiple sites for biocapitalization: science, the market, policy and funding institutions. This project will focus on how these interact and encounter one another. The aim is twofold: first, to provide new empirical insights about how biocapitalization processes are enacted in practice and at strategic sites, using cross-disciplinary methods from actor-network theory, the humanities and economic sociology; second to contribute analytically and methodologically to the field of Science and Technology Studies (STS) by drawing on resources from economic sociology and the humanities in order to provide an analytical framework for comprehending biocapitalization practices.

Keywords: valuation studies,bioeconomy,material semiotics,science studies
A compact, unmanned, renewables-powered and self-sufficient vessel able to pick up marine litter and to treat it on board for volume reduction and energy recovery (Sea Litter Critters)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project intends to explore the feasibility of introducing to the market Sea Litter Critters, a compact, unmanned, renewables-powered and self sufficient marine litter collection and treatment vessel based on a patent pending device treating waste thermally with plasma technology and no harmful emissions. This device is designed to operate near the shores especially nearer tourist facilities substituting the mechanical collection of litter currently adopted. By picking up litter (plastic debris mostly) near the point of entry, Sea Litter Critters contribute to minimising the pollution risks linked to plastic in the sea, where plastic items become brittle and break down into small particles, but basically never dissolve. Such particles can be eaten by zooplankton thus enter the foodchain. Therefore picking up plastic debris while still intact and as soon as possible after their disposal supports and complement in the short term all the high level policy actions for litter prevention (minimisation of waste, use of biodegradable plastic, awareness raising, beach clean up days etc.). This study aims to check the attractiveness of the innovation to the market involving potential customers (coast towns, associations of tourist and fishing ports and marinas, representatives from the cruise and hotels industry, marine natural reserves authorities). The first markets identified are on the Mediterranean Sea, which is at the center of a very highly populated area of the World with many Countries relying mostly on tourism. Studies confirm that the Med has mostly marine litter derived from this economic activity and up to 80% of it originating from land. Italy, with its over 7600km long coastline and a strong dependency upon tourism, will be the first market, followed suit by France and Croatia and then Spain and Greece. After a 3 year phase to cover development, industrialisation and commercialisation, production is expected to start in 2019, with employment of 17 new staff.

Keywords: marine litter,on board litter management,coastal management
Ribosome inhibition by nascent or antimicrobial peptides (NascenTomiX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1999125.0
EU funding (EUR): 1999125.0
Participants: 1
Project status: SIGNED

During the translation of genetic information into protein by the ribosome, nascent peptides occasionally inhibit their own synthesis by interacting with the exit tunnel of the large ribosomal subunit. Known as nascent chain-mediated translational arrest, this process depends primarily upon the amino acid sequence of the arrest peptide. However, it can also rely upon the sensing of a low molecular weight ligand by the ribosome nascent chain complex, explaining its use for metabolite-dependent gene regulation in both bacteria and eukaryotes. Biochemical and structural studies of arrest peptides have yielded key insights into their mode of action, but their ability to sense different types of small molecules, their impact as regulators of gene expression in nature and the precise molecular details behind the arrest process are still largely unexplored. The groundbreaking aim of this ERC Consolidator research program is to decipher the arrest code governing nascent chain-mediated translational arrest in bacteria. My approach will be based on a technique recently developed in my group, referred to here as inverse toeprinting, which precisely maps the position of an arrested ribosome nascent chain complex on the mRNA while retaining the entire peptide-coding region up to the point of stalling. The overall aim will be achieved through four complementary objectives: (i) to assess the extent to which arrest peptides can act as small molecule sensors; (ii) to identify naturally occurring arrest peptides in bacteria; (iii) to develop trans-inhibitory peptides that target the ribosome; and (iv) to perform the structural characterization of new ribosome inhibitory peptides. By addressing the natural diversity and molecular bases of the arrest process, this project will be the key to understanding a unique form of gene regulation and a fundamental aspect of ribosome function. It will also provide a handle for designing next-generation antibiotics.

Keywords: ribosome,protein synthesis,bacterial gene regulation,nascent chain mediated translational arrest,arrest peptides,antibiotics,antimicrobial peptides,antibiotic resistance
First R'n'D and Physics Results with a Novel Opaque Neutrino Detector (LORD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

LANDs (Liquid scintillator Anti-Neutrino Detectors) have been for decades in the forefront of reactor neutrino fundamental research, yielding groundbreaking results. Despite success, LANDs are known to have a rather poor event-wise background rejection capability. LiquidO is a novel neutrino detection technology which, while inheriting much from LANDs, relies, in total opposition, on the unique exploitation of an opaque liquid scintillator to yield a breakthrough performance in terms of background rejection. Our project deals with first LiquidO R&D (LORD) steps to demonstrate LiquidO's unprecedented ability in terms of physics detection performance with reactor antineutrinos, where a positron is to be uniquely identified as the signal (via Inverse Beta Decay reaction), thus rejecting most (or all) the backgrounds known so far. The goal is to exploit LiquidO's effective light confinement to reach a unprecedented spatial resolution (order 1cm), as compared to LANDs (typically >10cm). The researcher will thus develop and tune a high accuracy simulation using data-driven results obtained from two dedicated table-top prototypes. Then, he will demonstrate that LiquidO can be both (a) an effective background-less and (b) IBD directionally sensitive detector, among the most challenging (so far impossible) detector capabilities for any reactor neutrino detector today. The researcher will design and optimise a hypothetical LiquidO detector (via the tuned simulation) studying those capabilities, both relying on the same exploitation of the now resolvable non-point-like positron energy deposition caused by the annihilation gammas, thus discriminating from any other background final state (electron/gamma/proton-recoil). Such experimental capabilities so far impossible will provide a breakthrough training scenario for the researcher to culminate his preparation as a mature researcher in fundamental physics beyond today's state of the art detector technology.

Keywords: neutrino,antineutrino,reactor,randd,detector,liquid scintillator,ibd directionality,background rejection
A breakthrough LED driver that brings a smaller, cheaper, lighter and more environmentally friendly solution to the LED lighting industry. (NRGDriver)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Netherlands
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Since its inception, LEDs are driven by a constant voltage or current with some compensation for temperature fluctuations. As the power grid works on alternating current, a rectifier circuit is required, in virtually all cases combined with a DC convertor. This type of circuitry is constructed along the principles of a switched mode power supply, which requires a reactance. In short: current LED lamps contain complex constructed technologies, which limits lifetime, reduces design versatility and increases costs. We take a different approach. NRGDriver is built by discrete components and semiconductors. The size of the solution does not grow with increasing power requirements and it comprises only about 10 components: less components means less cost, less failure and less waste of energy. While current drivers are considered to be the Achilles’ heel for LED lighting, the concept of NRGDriver offers a breakthrough in LED driver technologies, making possible the same revolution in size, function and cost as happened to mobiles phones – but now in 1 jump. So far, we have invested more than €1.5M into the development of the NRGDriver to ensure its robustness and efficiency. We now seek further investments of about €1.45M. This sum will allow us to surpass the so-called “valley of death” and reach commercialization. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of NRGDriver and its market uptake.

Keywords: driver,temperature,efficient,lifetime,lighting
An innovative business model: turning domestic used cooking oil into renewable “fuel” for education and entrepreneurship (InnovOleum)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Cyprus
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Used cooking oil (UCO) is an excellent feedstock for advanced biofuel production. In fact, the market for the conversion of used cooking oil (UCO) from the hospitality sector into biodiesel is well established. However, even though around 854,000 tonnes of used cooking oil is produced from households in Europe, the extremely promising market of domestic UCO is generally untapped. In Cyprus, this market gap is being addressed by an innovative project that, through a solution-oriented approach, has proven that a harmful waste can be transformed into a source of income and innovation for the most vulnerable groups of our society: children and unemployed youth. Project “Tiganokinisi” makes schools the collection hubs of domestic used cooking oil, with each student bringing oil from her/his household and neighbourhood. The profit from the sale of the UCO is returned to the school for the implementation of green technologies and infrastructure. The entire initiative is tightly coupled with educational innovation (formal, informal and non-formal education). The project, which overcomes several of the obstacles previously identified in domestic UCO collection and which can become self-sustained within 5 years, promotes resource efficiency and environmental protection, while creating jobs in a niche market of the green economy. It helps Member States meet several EU targets related to the Waste Framework Directive, Resource Efficiency and Renewable Energy. It has therefore attracted the attention of NGOs around Europe and the world. There is international interest to replicate its success, and therefore there is a business opportunity. As such, ISOTECH, aims to develop a “blueprint” that will allow the replication of Tiganokinisi in other countries, through a licensing/franchising scheme that will begin with the implementation of a bundle of consultancy services and support for setting up the project.

Keywords: domestic used cooking oil,innovative education,entrepreneurship,resource efficiency,renewable energy
Eucor Upper Rhine Immunology doctoral programme (EURIdoc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-09-01
End date: 2027-05-31
Duration (months): 69.0
Total project cost (EUR): 6074880.0
EU funding (EUR): 3037440.0
Participants: 1
Project status: SIGNED

EURIdoc is a Eucor - The European Campus joint doctoral programme in the field of immunology. Doctoral students are selected through a transparent, merit-based and international recruitment process and hired by the Eucor members University of Basel (Switzerland), University of Freiburg (Germany), Karlsruhe Institute of Technology (Germany), University of Strasbourg (France) and the Freiburg University Clinic (Germany). The programme is strongly connected to the regional, tri-national ecosystem of the Upper Rhine Region and contributes to knowledge transfer across disciplines, sectors and borders. EURIdoc unites 50 researchers recognised for their excellence in immunology research, their engagement in health and in translating discoveries to concrete applications. EURIdoc benefits from the expertise of Eucor’s doctoral and graduate schools for recruitment and training. It innovates in the supervision of early stage researchers by associating supervisors with cosupervisors and educational mentors form different research institutions and/or sectors. It has access to state-of-the-art technical platforms. It can rely on a well-functioning and dynamic community of immunology researchers, lectures and clinicians. Training sessions for doctoral candidates are organised to provide disciplinary, interdisciplinary, intercultural and intersectorial training. The industrial sector is represented by small medium enterprises and big pharma companies that have committed to provide mentorships, seminars and secondments. Dissemination and outreach strategies include publications in high impact scientific journals, multi-media public communication, participation in citizen science and in patient associations. EURIdoc provides a framework for excellence in research and doctoral training with high level and international standards through trans-national, intersectorial collaborations, exchange and networks across Europe.

Keywords: european doctoral programme,life sciences,immunology,biomedicine,health,immune related,diseases,cancer
Establishment of services enhancing the innovation management capacity of SME's through the Enterprise Europe Network in IRELAND (IRL-SME-Innovation)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Ireland,Ireland,Ireland
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 211600.0
EU funding (EUR): 211600.0
Participants: 4
Project status: CLOSED

Our proposal is aimed at providing specialised consulting services for building innovation management capacities in SMEs as well as supporting SME beneficiaries from H2020 funding through the KAM - Key Account Manager - role in overseeing specialist coaching services after assessment on innovation weaknesses.

Keywords: enterprise europe network,ireland innovation support