Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next-Generation of Interior models of (Exo)planets:Studying the interior structure of giant planets and its effect on their evolution, atmospheres and observations (N-GINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1998802.0
EU funding (EUR): 1998802.0
Participants: 2
Project status: SIGNED

The prevalence of metals in exoplanet atmospheres is considered an important tracer of the formation of gas giants. However, the current theoretical framework is founded on the critical assumption that such planets are composed of a core surrounded by a homogeneous and well-mixed envelope. Recent data from Cassini and Juno show differently, resulting in a paradigm shift in the interiors of Jupiter and Saturn. Jupiter's envelope is now shown to be non-homogeneous, leading to new pathways for studying the interactions between giant planet interiors with their atmospheric constituents. This new knowledge desperately needs to be incorporated in exoplanet studies. This is the aim of N-GINE. We are in a unique time for this study. We have extraordinary data to study the giants in the solar system, and the JWST will provide exceptional data on exoplanets’ atmospheres. Now is the time to gather the stunning amount of exoplanet data and the detailed insights supplied by our solar system and get integrated knowledge coming from all giant planets. I have unique expertise in these fields to fill this gap and lead a team of 3 PhD students and 2 postdocs to work at the frontier of exoplanets and solar system science. We will provide the community with the first open-source retrieval tool for exoplanet interiors based on my state-of-the-art models for Jupiter, use JWST to compile the first database on refractory species in exoplanet atmospheres (indicating the solids accreted during formation), study atmosphere-interior interactions with self-consistent atmospheric radiative transfer and interior models, and go beyond the state-of-the-art with new interior models for Jupiter, Saturn, Uranus and Neptune with non-homogenous interiors and using Neural Networks. The impact of the new interior models developed in N-GINE will also affect atmospheric chemical and retrieval calculations, revolutionizing the way of interpreting observations in exoplanets and learning about their origins.

Keywords: exoplanets,giant planets,planet formation,exoplanet atmospheres,planet interiors
DNA-encoded REconfigurable and Active Matter (DREAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2496750.0
EU funding (EUR): 2496750.0
Participants: 1
Project status: SIGNED

Synthetic materials exist in a broad variety of sizes, shapes and compositions leading to an impressive breadth of useful functions but tend to be case-specific. Living matter, in contrast, has the remarkable capability to sense, evolve, transform and adapt. Here, we propose to develop new DNA-encoded dynamic principles and implement them as molecular codes to program similar life-like characteristics in a variety of synthetic soft materials, ranging from evolutive DNA nanomachines to genetically encoded active interfaces. Various DNA nanostructures (DNA origamis, single-stranded tiles, DNA nanogrids) will be produced by a new concept of isothermal and reconfigurable DNA self-assembly, leading to user-defined self-assembled structures capable to adapt and morphologically transform, autonomously or in response to a stimulus. Coupling proteins to these reconfigurable nanoscaffolds will allow us to reconstitute dynamic synthetic metabolic pathways, design programmable catalytic switch or develop a new principle of nanostructure discovery by evolution. Beside encoding structural dynamics, we will also incorporate gene-containing DNA in interface-rich materials (films, drops, emulsions) to program, at a genetic level for the first time, the active behaviour and dynamic functionality of these systems. In situ cell-free expression of interfacially active proteins, such as BslA and hydrophobins, will allow us to control the interfacial properties (surface tension, visco-elasticity), either uniformly or with controlled spatio-temporal patterns. This will result in original genetically encoded active behaviours such as genetic Marangoni effects, propulsion, genophoresis or autonomous genetic sorting. Additional functionality will be brought by co-expressing useful proteins (enzymes, antibodies) at these interfaces, resulting in highly dynamic, reconfigurable, versatile and multifunctional soft materials.

Keywords: soft matter soft materials nanoscience self assembly dna nanotechnology smart materials reconfigurable materials dna self assembly protein synthetic metabolism evolution nanostructure discovery photo actuation gene expression synthetic biolgoy reconstituted systems interfaces interfacially active proteins marangoni effect self propulsion active matter microfluidics antibody enzyme
Cr4+:YAG/Polymer nanocomposite as alternative materials for Q-switched lasers: properties, modeling, and applications (ALTER-Q)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Slovakia,Poland,Ukraine,Italy,Portugal
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 678828.57
EU funding (EUR): 584200.0
Participants: 8
Project status: SIGNED

The development and application of solid-state lasers (SSRs) over the last decade, emphasizing their wide-ranging uses in fields such as metal processing, medical applications, and optical transmission systems. It outlines the fundamental components of SSRs and the importance of achieving a balance between gains and losses in the laser resonator for effective generation. The concept of Q-switching is introduced, highlighting its role in enhancing laser performance by modulating the Q-factor of the resonator. Active and passive Q-switching methods are compared, with a focus on the advantages of passive Q-switches for generating powerful sub-nanosecond pulses in compact laser systems. The challenges associated with finding suitable passive Q-switching materials, particularly for long-term use, are discussed, leading to the proposal of a novel approach using a composite structure of polymer matrix with Cr4+:YAG nanopowders. This initiative, undertaken by the ALTER-Q consortium comprising European academic institutions, research organizations, and SMEs, aims to address the current limitations and pave the way for cost-effective alternatives in Q-switched laser technology.
Towards a smart plant protection in European farms: An integrated living farm lab approach (bioconfarm)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Germany,Slovakia,Austria,Hungary,France,Italy,Spain
Call: Thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2025-08-01
End date: 2029-07-31
Duration (months): 48.0
Total project cost (EUR): 2774800.0
EU funding (EUR): 2774800.0
Participants: 13
Project status: SIGNED

bioconfarm will use a holistic approach in which all stakeholders along the entire value chain of agriculture and plant production will be considered, especially the farmers, SMEs, cooperatives and scientists. The bioconfarm consortium will establish an international “living” network of experts and stakeholders in the field of alternative plant protection and plant strengthening research & innovation, paving the way to reduce the application of chemical and synthetic pesticide products in agriculture and forestry. The bioconfarm thematic network focuses on the topic of smart plant protection research findings and innovation fulfilling the needs of farmers and plant breeders. bioconfarm will apply a user-centred approach (the bioconfarm living farm labs), which will act as a kind of open-innovation ecosystem, operating in a territorial context (certain region) and integrates concurrent research and innovation results and processes. A sustainable and long-lasting network of living farm labs will be established and take-up of research findings by farmers increased. Knowledge exchange in rural areas is mainly based on physical meetings and direct relationship between people and can be organized in a way that facilitates the mutual learning process. For example, demonstration farms are an effective means for knowledge exchange as farmers and researchers directly meet each other and build long-term relationships. The living farm lab approach of bioconfarm applies a multi-actor approach in order to integrate all relevant actors and stakeholders along the several value chains concerning plant health in agriculture. bioconfarm structure consists of five comprehensive and inter-related Work Packages with key outputs as deliverables, as well as major milestones plotted along the workplan. bioconfarm comprises 13 project partners (11 main beneficiaries, 1 affiliated entity and 1 associated partner) representing expertises in agriculture, plant protection, biocontrol, digital tools, producers, farms, cluster and cooperatives.

Keywords: living farm lab,smart plant protection,alternative protection,prevention,plant health,soil health,best practices
Synthetic Life from the bottom up (SynLife)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 2289954.0
EU funding (EUR): 2289954.0
Participants: 1
Project status: SIGNED

Life is a mystery, with questions about how it emerged and if it exists elsewhere. Synthetic life can bring us closer to answers to these millennia-old questions. It is also extremely powerful to evolve new materials and catalysts, similar to directed evolution with bacteria. It begs the question, can we synthesize life? SynLife aims to synthesize life from man-made molecules following NASA’s definition:Life is a self-sustaining system capable of Darwinian evolution. Chemically fueled droplets will be the self-sustaining compartments. These self-dividing droplets compete for fuel (i.e., food) to thrive and will decay without fuel. We will develop self-replicating molecules that can mutate and partition inside of these droplets, so the droplets obtain an identity. For example, a population of droplets with replicator A differs from a population with replicator B. Moreover, these replicators affect the droplet’s phenotype, for example, by helping division or by offering longevity. To date, the combination of self-sustaining droplets and replicators has never been achieved. Finally, populations of droplets compete with each other. In fueling-starvation experiments, it is expected that, from time to time, a droplet mutates into a better-suited one and passes this information on to the next generation. If we reach this ambitious goal, we have produced a synthetic system capable of Darwinian evolution. The results will mark a massive step forwards in our understanding of life. It also sheds new light on the molecular mechanisms that may have played a role in the origin of life. It will have implications for the biophysics community, too, as our findings help understand how additives to droplets affect their properties, just like in membraneless organelles. But, most excitingly, SynLife will change how we think of material design by introducing Darwinian evolution as a manufacturing tool.

Keywords: synthetic life
ENHANCING BIODIVERSITY AND SOCIAL INCLUSION BY TRANSFORMING EUROPE’S LIVING ENVIRONMENTS (INNATURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Finland,Belgium,Netherlands,Romania,France,Denmark,United Kingdom
Call: Demonstrating the potential of Nature-based Solutions and the New European Bauhaus to contribute to sustainable, inclusive and resilient living spaces and communities (HORIZON-CL6-2024-BIODIV-02, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 5100633.75
EU funding (EUR): 4999758.75
Participants: 21
Project status: SIGNED

Nature Based Solutions (NBS) can support biodiversity, human health and well-being, climate adaptation and resilience, and can reduce pollution and climate change. In reality, many NBS fail to maximise these benefits or do not work over time, exacerbated by a lack of community involvement. The INNATURE project ambition is to change this and to deliver five diverse demonstration cases across Europe that maximise NBS co-benefits and that will demonstrate best ‘next practices’ in design solutions and processes and upscaling and acceleration of NBS in different contexts. It will do so by bringing biodiversity and people diversity together at all levels (i.e. diverse communities, artists and designers, ecologists, researchers, policy-makers, other stakeholders) and thereby reimagining new (biodiverse, social, cultural and ecological) futures. The New European Bauhaus (NEB) will act as a foundation for the co-production of NBS and all of the INNATURE NBS actions will be NEB ‘by design’, thereby transforming and diversifying existing living environments that will demonstrate how NBS solutions can be inclusive, resilient and adaptable to changes, affecting policy and changing mindsets. More specifically, the INNATURE project will: (1) co-produce and demonstrate NBS that are NEB (New European Bauhaus) ‘by design’ through Eco-Social Living Labs. (2) protect, celebrate and enhance existing local biodiversity through Art Conversations and collaboration and biodiversity actions with local ecologists. (3) ensure long-term resilience of the NBS through a Holistic Monitoring and Evaluation Framework (including citizen science), facilitated by an Integrated Digital Platform. (4) use NBS to re-imagine new living futures in Europe and create a Local Community Economy-Ecology Value Framework; and (5) map these processes and results in a new framework and practical guidelines for ‘NEB-by-design’ NBS, culminating in the INNATURE Pattern Book.

Keywords: nbs,neb,built environment,arts,biodiversity,ecology,living lab,co creation,demonstration,digital platform,citizen science
Radial Glia as Neurodevelopmental Mediators Of Gut Microbiota Signals (RADIOGUT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

Brain development is an intricately orchestrated process, that is sensitive to the influence of peripheral processes. One such peripheral factor known to have multiple roles in host physiology, is the gut microbiota: the ecosystem of symbiotic microorganisms that populate our gastrointestinal tract. Disruption of the gut microbiota has been associated with neurodevelopmental and neuropsychiatric disorders. However, the mechanisms through which the gut microbiota could influence brain development, and thus potentially lead to cognitive and behavioural deficits, remain to be elucidated. RADIOGUT aims to mechanistically understand the interactions between the gut microbiota, and brain neurodevelopment at molecular and cellular levels. To accomplish this, we will employ distinct models of early-life microbiota disruption in mice and assess the impact on neurodevelopment combining explant cultures with microbial metabolites, and an integrated multi-omics analysis. We will identify key microbial metabolites that modulate neurodevelopment, discern their signalling mechanisms and their potential to rescue neurodevelopmental deficits as well as later life aberrant behaviours. RADIOGUT will explore for the first time how the primary neural stem cells in the brain, the radial glia, can act as cellular sensors of microbial signals that modulate neurodevelopment. It will fill a large gap in the understanding of microbiota-gut-brain axis development and its communication code, as well as deliver tangible future translational value.

Keywords: radial glia,microbiome,blood cerebrospinal fluid barrier,microbiota gut brain axis,gut microbiota
Hacking the ribosome to map virus-host associations (VirHoX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,France,Norway,Austria,Germany
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 8
Project status: SIGNED

High throughput sequencing and metagenomics have deepened our understanding of viruses in nature, yet linking viruses to their hosts remains a challenge, hindering our knowledge and applications. The VirHoX project aims to overcome this by "hacking" the ribosome to map virus-host associations. Leveraging a critical moment in the infection cycle of all viruses, the translation of viral genes into proteins by the host cell, we will uncover concealed relationships between viruses and their hosts, providing a universal tool for virus-host pairing. This novel approach, VirHo-seq, involves ligating host ribosomal RNA with viral mRNA during translation in infected cells using engineered enzymes, followed by high throughput sequencing to reveal virus-host pairings. Our interdisciplinary consortium of academic and industrial experts in microbiology, protein engineering, gene editing, viral genomics/transcriptomics and law, will develop and then prepare the commercialisation of VirHo-seq, envisioning legislative and analytical frameworks to maximise its impact. This technology will significantly help tackle current challenges, such as those posed by emerging pathogens, ecological disruptions, and climate change. Our approach aligns with the EIC Work Programme objectives, demonstrating feasibility on model organisms before validating on relevant samples, addressing the "engineered living materials" challenge.

Keywords: virus host associations,environmental viromics,ribosomes,mrna rrna ligations,recombinant proteins,protein engineering
Manufacturing Architecture for Resilience and Sustainability (MARS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: France,Switzerland,Netherlands,Greece,Germany,Spain,Norway,Czechia
Call: Excellence in distributed control and modular manufacturing (Made in Europe Partnership) (RIA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5142377.5
EU funding (EUR): 5142377.5
Participants: 13
Project status: SIGNED

European manufacturing SMEs represent a major pillar of the EU economy but, even though some of these SMEs are world’s champion in their own business area, they are still threatened by the lack of radical technical innovation as well as successive crises of their supply chains. The MARS project aims to remedy to both issues by enabling SMEs to access advanced European breakthrough innovations in the field of AI-driven digital manufacturing processes and enter into process chains that are geographically distributed. Specifically, by gathering diverse expertise coming from complementary European partners, MARS will develop Industry4.0 emerging technologies including digital twins of products, processes and machines, bio-intelligent production devices with local intelligence and high sensing coverage, central intelligence with fleet learning approaches, data-driven manufacturing process models from different sources, blockchain technology for data hashing, traceability and securitization, multi-agent based manufacturing planning, multi-criteria intelligent optimization of processes and resources especially addressing environmental footprint. As a result, the impact of the project will lie into introducing radical flexibility in all different aspects of manufacturing processes, in particular by redefining the process route, raw material, resources, technology, throughput, manufacturing site, delivery date in no time, while keeping up with product’s requirements, proven product quality and sustainability of both processes and products. By demonstrating its results on two case studies exhibiting advanced manufacturing processes (incl. homogeneous and heterogenous data), MARS will show how SMEs can decrease time delivery under difficult economical boundary conditions, while targeting ambitious energy-saving environmental objectives.

Keywords: flexibility manufacturing reconfigurability traceability ai models federated learning data driven process planning blockchain resilience