Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Study of the role of m6A RNA methylation in the nervous system of Drosophila melanogaster: an in-vivo model to dissect the impact of epitranscriptome reprogramming in physiology and cancer (EpiMethFly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-19
End date: 2020-04-18
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The identification of reversible m6A RNA modification strongly points towards the existence of a novel level of complexity of gene expression regulation. Recent studies have suggested that m6A might be involved in several biological processes and that dysregulation of this modification may contributes to neuro-developmental abnormalities and cancer. The aim of the described research is to clarify the role of m6A RNA modification in the nervous system in physiological conditions -during brain development - and to discover its contribution to pathological conditions - Glioblastoma. To achieve this goal I propose to use Drosophila melanogaster to study : Aim 1 the impact of perturbing different members of the m6A machinery on brain morphology, progenitors differentiation and neuronal axon growth and guidance; Aim2 the impact of modulating the levels of m6A RNA modification in a Glioblastoma model and study the effect of this perturbation on tumor growth and progression. The results obtained will be of fundamental importance for the development of the field of epitranscriptomics by shedding light on the biological outcome of m6A modification in-vivo. In particular, Drosophila might become an efficient model to screen for novel members of the m6A machinery and to clarify how m6A is read and translated into a biological response. Finally, the data obtained by the analysis of the Glioblastoma model, will strongly contribute to the understanding of the link between RNA methylation and tumor development and aggressiveness.

Keywords: drosophila melanogaster,m6a rna methylation,axon guidance,brain wiring,glioblastoma
Innovative Laser and Fiber System for Non-Toxic, Efficient and Cost-Effective Treatment of Cancer (LUMAX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our aim with this proposal is to bring the desired technology for a non-toxic, efficient and cost-effective cancer treatment. Basically, all cytotoxic drugs (chemotherapy) and radiation lead to apoptosis, the programmed cell death of tumor cells. These techniques on the other hand have well documented side effects like losing hair, teeth, damaged quality of life effecting lives of more than 14M cancer patients and their families worldwide. LoF revolutionizes "non-toxic" cancer treatment with her innovative laser probes and systems serving oncologists tasked with saving lives by developing and applying the most effective therapies. Our state-of-the-art laser probes and systems form a feedback loop and enable oncologists for the “first time” to monitor absorbed dose to the tissue in real time which is decisive for the treatment efficacy. Cancer cost the EU €126 billion in 2013, with health care accounting for €51 billion (40% of the total cost) for post-treatments. EU needs better, effective solutions to drive costs down. With our solution which is the subject of this proposal we offer a potential cost-saving of 60%. The market potential for the envisaged the clinical applications is based on current cases at around 2.24 billion euros worldwide. Our innovation opens the door to new treatment applications and could be used to treat up to 5 million people per year from 2022.

Keywords: laser surgery,minimally invasive surgery,non toxic tumor treatment,fiber optics,cancer treatment,smart surgical systems
Towards Elemental Identification in Single Molecules using Atomic Force Microscopy (EIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: CLOSED

Molecular structure determination is vital for biochemistry, life science, and drug industry. A complete determination of the molecular structure requires both the structural skeleton and atoms therein to be identified. Non-contact Atomic Force Microscopy provided a method to image the real-space structural skeleton of planar organic molecule, however, the chemical identities of each atom that comprise the molecule are yet to be determined. In this proposal, I systematically analyze the physical principle for elemental identification in single molecules and propose a practical method to identify each atom using point spectrum with non-contact atomic force microscope.
Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol. (POMOLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%. It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility. Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues. Whether these alterations are also found in PCOS oocytes remains unknown. Cumulus cells (CCs) are specialized cells that maintain paracrine signals and cell-to-cell communications with the oocyte to support the acquisition of competence to derive an embryo. This crosstalk is important in PCOS since the reduced oocyte competence is considered the potential causative factor of infertility. PCOS women seeking in vitro fertilization (IVF) treatments suffer greater sensitivity to hormonal treatments, which can lead to a high risk of ovarian hyperstimulation. In vitro maturation (IVM) of oocytes has been introduced in the human fertility clinic as a mild-approach alternative to conventional IVF as it requires minimal stimulation of the ovaries. However, there is a need to further develop a better protocol that curtails the 30% gap efficiency existing between IVM and IVF. This project aims to 1) generate DNA methylation and gene expression profiles of PCOS oocytes and paired CCs using single-cell and low-cell parallel sequencing, 2) create an improved, safe and robust IVM system that can increase oocyte competence for these patients and 3) define the molecular pathways that are differentially regulated in oocytes and CCs after in vitro maturation. The project will benefit from the experience in fertility treatments and safety assessment of the host supervisors, Profs. Smitz and Anckaert. The access to human material will be granted by the home institution. In addition, a secondment in Dr. Kelsey’s laboratory (Cambridge, UK) will provide pioneering single-cell technologies.

Keywords: dna methylation,polycystic ovarian syndrome,single cell sequencing techniques
Cost-efficient and safe cellulosic food pad (CellSorb)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 3290163.75
EU funding (EUR): 2303114.63
Participants: 1
Project status: CLOSED

Food pad absorbers used in the fresh food packaging to soak up the exuded liquid and keep food fresh are made of synthetic superabsorbent polymers (SAPs) – i.e. 90% of the market share - due to their superior price-efficiency balance. Nevertheless, proven toxicity and carcinogenic effects related with their use have raised growing health concerns. To put these dangerous practices aside, the need of economical biodegradable and non-toxic pads to compete with the synthetic ones are on the rise. CELLCOMB a Swedish company specialized in cellulose-based laminated products, has developed CELLSORB- a totally safe (i.e. non-toxic) closed food pad made from bioplastics and natural absorbent micro-cellulose material with the following superior features: 1) highly absorption capacity, similar with the performance of synthetic food pads, 2) It is fully compostable and 100% renewable, and 3) Competitive pricing over synthetic made food pads. Through CELLSORB, we will position us as a competitive company in the framework of alternative natural absorbent materials for fresh food packaging. We expect to reach around 20% share of the European food pad industry by 2026. Our highly absorbent micro cellulose material will not only be constrained to the food pads but in a long term it will expand its application to other known verticals like diapers, feminine hygiene and wound care products, highly demanded. The impact of CELLSORB in our whole business is expected to allow us growing 5-fold, and reaching an EBITDA of €12.1 million by 2026.

Keywords: safe food pads,biodegradable,microcellulose,process engineering
Privacy Preserving Secure Speech Recognition (PPSSR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 97500.0
EU funding (EUR): 97500.0
Participants: 1
Project status: CLOSED

The aim of this project is to overcome barriers to the recruitment of highly qualified specialist (PHD or equivalent ) in semantic cryptography for speech processing that cannot be recruited on the national job market, but whose knowledge would be crucial to open up opportunities for innovation and significant growth for our business by realising secure speech recognition in the cloud.
Carbon nanotube based nanomechanical qubit (CNTQUBIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

This proposal outlines our vision for generating the first mechanical quantum bit (qubit) ever produced. The qubit will be realized with a carbon nanotube (CNT) in two steps. First, a carbon nanotube mechanical resonator is prepared in its quantum ground state and strongly coupled to an embedded electronic two-level system (eTLS). The eTLS is realized by carefully tuning the energy states of two spatially distinct charge quantum dots until they hybridize. This double quantum dot is hosted along the suspended carbon nanotube and localized such that it couples strongly to a high mechanical quality factor vibrational mode. Secondly, the strong coupling between the emergent eTLS and the CNT mechanical mode enables a tunable and strong anharmonicity in the mechanical restoring potential. This anharmonicity makes it possible to use the system as a qubit, which will be realized by integrating the nano-electromechanical (NEMS) device with a superconducting microwave cavity. This allows for the mechanical qubit to be coherently addressed and sensitively read-out using the state-dependent frequency shift imparted by the qubit on the superconducting cavity.

Keywords: carbon nanotubes,electromechanics,nems,electron transport,qubit,cavity electromechanics,quantum optics,quantum information processing
The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory Consolidation (DREAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Storing information and then using it to guide behaviour is one of the most remarkable abilities of the brain. Memory storage relies on network mechanisms in which the hippocampal formation interacts with the rest of the brain during periods of sleep. The neural computations associated with this process correlate with both enduring and transient changes in the excitability of neural circuits. Nuclei located in the brainstem dictate these ‘state changes’, modulating the signalling between groups of forebrain cells. However, the role of the brainstem in memory formation remains unknown. This project aims to determine the role of different sleep stages in memory formation and long-term consolidation, and to elucidate the functional role of the brainstem in these processes. To this end, I will use a battery of experimental techniques, mathematical methods and biophysical models to probe and analyse the neural activity of the brainstem-hippocampal system. Neuronal activity will be recorded concurrently from the pons, thalamus and hippocampus of mice while performing a reference memory task. I will identify specific neural mechanisms that trigger different hippocampal synchrony regimes and memory reactivations mediated by brainstem activity during wakefulness and sleep. For this, I will develop state-of-the-art methods based on signal processing and machine learning. Besides, using optogenetic tools, I will determine the causal role of the brainstem in regulating hippocampal circuits and the animals’ behavioural performance. Finally, I will develop a biophysical model to test how well different network mechanisms explain the dynamics of the interactions between the brainstem and the hippocampus. Understanding the detailed properties of the interactions between these systems of the brain in relation to memory processes will be an important step toward establishing neurophysiological markers that can be preventive targets to ameliorate effects of memory-related pathologies.

Keywords: hippocampus,learning,memory,sleep,brain rhythms
Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity (ADIMMUNE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

Keywords: microbiome,adipose tissue,immune regulation
Computational Proteomics Training European Innovative Network (PROTrEIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Austria,Spain,Finland,Belgium,France,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3917904.12
EU funding (EUR): 3917904.12
Participants: 12
Project status: SIGNED

PROTrEIN is a Training Network composed of 12 beneficiaries, and 8 partner organizations, from the academic and non-academic sectors with the mission to train a new generation of specialized bioinformaticians and improve their future employability while tackling the main challenges in computational proteomics. Mass spectrometry (MS) is one of the most powerful technologies for the study of the cellular proteome, and it is present in many translational research projects for the diagnosis and prognosis of multiple diseases, and for elucidating the mechanisms of action of drugs of medical interest. While several proteomics workflows are well established, the field is fast evolving with new acquisition methods and high-content data structures that expand the applications of the technology and make it one of the principal platforms in the multi-omics universe. Many of these developments require the assistance of artificial intelligence for the acquisition of next generation proteomics datasets, as well as the development of new processing algorithms to reveal hidden proteoforms, interactions, and protein modifications. Moreover, the usage of the new experimental possibilities requires the development of interactive and highly-visual tools for the integration and presentation of proteomics data with other omics datasets. Although addressing these different needs is crucial to deliver major contributions in our understanding of biological processes, the shortage of sufficiently trained bioinformaticians represents a major limitation. Therefore, PROTrEIN puts together an ambitious scientific and training programme to tackle both the challenges in proteomics research and the training of highly valuated professionals by mastering them on: a) the MS raw data structure and information content, b) MS acquisition methods, c) algorithms, gamification, and machine learning tools, d) data integration and visualization, e) science communication, f) data management, and g) RRI.

Keywords: machine learning,gamification,data integration and visualization,multi omics,peptide post translational modifications,proteoforms