Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reversal of anti-cancer drug resistance (SCANRESIST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Worldwide in 2018, cancer has been responsible for around 9.6 million deaths, and with a prediction of a further increase in incidence over the next years – which calls for urgent better treatment modalities to combat such deadly disease. Resistance to anticancer therapy is considered the main obstacle to successful clinical management of cancer patients. Scandion Oncology A/S (SCANDION) is a clinical-stage biotechnology company aimed to solve the anti-cancer drug resistance problem. We are developing a new drug, the SCO-101, which effectively targets some of the most common molecular resistance mechanisms in cancer. SCO-101 represent a paradigm shift in treatment of drug-resistant cancer, with multi mechanisms of actions in interfering with drug resistance. SCO-101 has previously passed four clinical phase I studies in healthy volunteers and proved to be a safe oral drug with very limited toxicity. The SCANRESIST project aims at performing clinical validation studies in taxane resistant breast cancer patients with open-labelled Phase II prospective clinical trial to establish SCO-101 Proof of Concept as a safe and efficient treatment modality. Our business model is based on out-licensing SCO-101 to pharma players active in anti-cancer drugs – who will be responsible for the remaining clinical development and market launch. The Phase II clinical validation has been pointed as a critical step achieve a deal with big pharma partners/licensees, which we know are interested in novel drugs with novel MoA, and with well-designed and well-performed phase II studies with positive results. Thus, the project will not only open a large market for SCANDION as it will also allow us to position the company as a unique provider of a new generation of anti-cancer resistance drugs – continuing our path on developing other drugs to combat drug resistance in cancer, innovative trial designs, predictive biomarkers and biomarker endpoints.

Keywords: chemotherapy resistance
Label-free 3D morphological nanoscopy for studying sub-cellular dynamics in live cancer cells with high spatio-temporal resolution (3D-nanoMorph)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Norway
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2025-06-30
Duration (months): 72.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Label-free optical nanoscopy, free from photobleaching and photochemical toxicity of fluorescence labels and yielding 3D morphological resolution of <50 nm, is the future of live cell imaging. 3D-nanoMorph breaks the diffraction barrier and shifts the paradigm in label-free nanoscopy, providing isotropic 3D resolution of <50 nm. To achieve this, 3D-nanoMorph performs non-linear inverse scattering for the first time in nanoscopy and decodes scattering between sub-cellular structures (organelles). 3D-nanoMorph innovatively devises complementary roles of light measurement system and computational nanoscopy algorithm. A novel illumination system and a novel light collection system together enable measurement of only the most relevant intensity component and create a fresh perspective about label-free measurements. A new computational nanoscopy approach employs non-linear inverse scattering. Harnessing non-linear inverse scattering for resolution enhancement in nanoscopy opens new possibilities in label-free 3D nanoscopy. I will apply 3D-nanoMorph to study organelle degradation (autophagy) in live cancer cells over extended duration with high spatial and temporal resolution, presently limited by the lack of high-resolution label-free 3D morphological nanoscopy. Successful 3D mapping of nanoscale biological process of autophagy will open new avenues for cancer treatment and showcase 3D-nanoMorph for wider applications. My cross-disciplinary expertise of 14 years spanning inverse problems, electromagnetism, optical microscopy, integrated optics and live cell nanoscopy paves path for successful implementation of 3D-nanoMorph.

Keywords: label free nanoscopy,live cell imaging,super resolution,inverse scattering
Uncovering the Magnitude of Arctic Climate Change (ARCTICO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2020-08-31
Duration (months): 13.0
Total project cost (EUR): 94686.8
EU funding (EUR): 94686.8
Participants: 1
Project status: CLOSED

A key challenge in climate change science is to provide informed constraints on the magnitude of future climate change. Uncertainties associated with such predictions remain large due to the shortness of our observational records (at best 150 years) and the absence of large climate shifts therein to serve as an analogue for future change. This is especially problematic when estimating Arctic climate change because the response in the Arctic is amplified relative to the global mean, making the Arctic the most sensitive and vulnerable environment with regards to global warming. Efforts to assess the magnitude of past (e.g. pre-industrial) climate changes using climate proxies are thus crucial to further our understanding of how the Arctic system will respond to continued global warming. The proposed investigation seeks to constrain the magnitude of Arctic amplification by quantifying the influence of the carbonate ion concentration of sea water on the temperature signal recorded in the Arctic planktonic foraminifera Neogloboquadrina pachyderma sinistral (NPS). Using NPS shells collected from stratified plankton samples, I will combine established and new analytical techniques in trace element and isotope geochemistry to derive and isolate carbonate system parameters from the climate signature recorded in NPS. This approach is innovative and interdisciplinary as it takes advantage of cutting edge knowledge in proxy development without compromising on the benefit of a seasonally and spatially constraint dataset. This will provide a holistic understanding of how changing hydrological and other environmental conditions impact not only NPS lifecycle but also the geochemical signal recorded in their shell. Given the uncertainties associated with available paleoceanographic tools this will provide a major advancement in the field of paleoceanography and climate change science.

Keywords: palaeothermometry,foraminifera,arctic amplification
Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silico study (SquaMem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2021-09-19
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Squalene is a natural lipid precursor, which plays a crucial role in the biosynthesis of sterols in the cells . Squalene is 100% biocompatible, not toxic and is able to enter into the cells easily. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called squalenoylation technology is based on fusing hydrophobic squalenic acid with the molecules of water-soluble drugs. Resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver the drugs into the target cells efficiently. Currently anticancer (gemcitabine , doxorubicin ), antiviral (dideoxycytidine ) and neuroprotective (adenosine ) drugs were used in this technology with great success. This project is devoted to revealing mechanisms of interaction of novel and highly promising squalene-based anti-cancer and neuroprotective drugs with cell membranes by means of in silico ccomputer simulations. The main goals of the project are the following: 1. To reveal how squalene-based drugs incorporate into the cell membranes, interact with membrane components and are released from the membranes on atomistic level of details. 2. To propose the ways of improving translocation of squalene-based drugs through the membranes in order to increase their therapeutic efficacy. The practical impact of the project is improving translocation of squalene-based drugs through the membranes and making it selective, which is of great interest for therapeutic applications of existing drugs and for creation of new compounds with desirable properties.

Keywords: cell membranes,squalene derivatives,molecular dynamics,anti cancer drugs,neuroprotective drugs
Statistical Methods For High Dimensional Diffusions (STAMFORD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Denmark,Luxembourg
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1655048.0
EU funding (EUR): 1504549.35
Participants: 2
Project status: SIGNED

In the past twenty years the availability of vast dimensional data, typically referred to as big data, has given rise to exciting challenges in various fields of mathematics and computer sciences. The increasing need for getting a better understanding of such data in internet traffic, biology, genetics, and economics, has lead to a revolution in statistical and machine learning, optimisation and numerical analysis. Due to high dimensionality of modern statistical models, parameter estimation is a difficult task and statisticians typically investigate estimation methods under sparsity constraints. While an abundance of estimation algorithms is now available for high dimensional discrete models, a rigorous mathematical investigation of estimation problems for high dimensional continuous-time processes is completely undeveloped. The aim of STAMFORD is to provide a concise statistical theory for estimation of high dimensional diffusions. Such high dimensional processes naturally appear in modelling particle interactions in physics, neural networks in biology or large portfolios in economics, just to name a few. The methodological part of the project will require development of novel advanced techniques in mathematical statistics and probability theory. In particular, new results will be needed in parametric and non-parametric statistics, and high dimensional probability, that are reaching far beyond the state-of-the-art. Hence, a successful outcome of STAMFORD will not only have a tremendous impact on statistical inference for continuous-time models in natural and applied sciences, but also strongly influence the field of high dimensional statistics and probability.
Process for the reuse of fly ash derived from waste thermal treatments as substitution of critical and toxic flame retardants in the plastic manufacturing. (COSMOS-Fenix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovakia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

COSMOS Fenix® (CF) is the trademark name of the patented process owned by Velaworks for the inerting of hazardous Air Pollution Control (APC) ashes derived from non-recyclable Waste Thermal Treatments, able to transform them into valuable secondary raw material (powder) that can be used as filler and flame retardant in plastic and rubber production. The easy and inexpensive process gives an effective answer to the huge problem of fly ashes landfill. At the same time, it offers to plastic and rubber manufacturers a very price competitive filler and flame retardant with very interesting flame resistant and strength properties, able to replace Antimony and Bromine in the plastics production process. The solution was validated at pilot scale at the waste thermal treatment plants of Brescia (Italy) and Bratislava (Slovakia), demonstrating the technical feasibility and the environmental safety of the process. The unique selling points are: • for Solid Waste Thermal Treatment operators → 20% reduction of cost for the disposal of APC (130 vs. 160 €/ton) with a potential saving for the sector in Europe of > 45M€/year; • for plastic manufacturers → flame retardants price equal to 380 €/ton, against the current market prices between 400 to 800 €/ton, with a saving up to 52%; no need of modifying the production process; safe and environmentally friendly material. Currently, about 2.4 million tons of APC ashes per year are treated in Europe, corresponding to a total Potential Market for CF of 1.200 M€/y, considering revenues from the treatment of the APCs and from sales of the secondary raw materials. The scope of Phase 1 is to demonstrate the technical/economical feasibility, achieving the following targets: i) Final Testing site for the pre-industrial plant installation (capacity = 400 tons/year) selected; ii) REACH authorization finalized for CF material; iii) First agreements with supply/value chain and stakeholders signed; iv) Customer validation performed.

Keywords: fly ash recovery,plastic fillers,flame retardants
Collecting Asteroid-Orbiting Samples: enabling a safer, sustainable, and autonomous exploration of asteroids (CRADLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Japan
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-15
End date: 2024-01-29
Duration (months): 32.0
Total project cost (EUR): 229704.64
EU funding (EUR): 229704.64
Participants: 2
Project status: TERMINATED

Exploring asteroids and other small bodies in the solar system is a challenging task, which carries immense scientific benefits. Our understanding of the early Solar System would advance greatly by studying the chemicals stored in carbonaceous asteroids. Through the development of advanced technology, we will be able to process asteroid material into fuel, oxygen, and water, making long-duration mission self-sustainable. Metallic asteroid could offer a great source of mineral resources through asteroid mining. The knowledge of asteroids composition is also fundamental to help defend our planet from possible impactor, enabling effective asteroid deflection missions. The overall aim of this action is to advance the way we design and operate deep space missions to asteroids, and especially, how we model, track, and collect asteroid fragments. They give invaluable insight on the composition and the dynamical environment of asteroids, as well as key information on how we can deflect them. The research objectives will be achieved through the theoretical studies on particle dynamics, the development of machine-learning algorithms for tracking them, and the design of a particle collection device to gather them in orbit. These objectives are relevant to H2020 Work Programme, specifically regarding the “market creating innovation” and “strengthening international R&I cooperation”. The approach combines my current skills with the ones that I will have acquired during the fellowship. I will improve my professional maturity and foster new collaboration under the supervision of eminent researchers, in preparation for an independent career.

Keywords: asteroid,space mission,sample collection,particle ejecta,collection device,instrument design,image processing
Title: Holistic Approach for Providing Spatial & Transport Planning Tools and Evidence to Metropolitan and Regional Authorities to Lead a Sustainable Transition to a New Mobility Era (HARMONY)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Cyprus,Greece,Greece,Norway,Greece,Poland,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Sustainable multi-modal inter-urban transport, regional mobility and spatial planning. (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-06-01
End date: 2023-02-28
Duration (months): 45.0
Total project cost (EUR): 7649645.25
EU funding (EUR): 7430894.5
Participants: 21
Project status: SIGNED

HARMONY envisages developing a new generation of harmonised spatial and multimodal transport planning tools which comprehensively model the dynamics of the changing transport sector and spatial organisation, enabling metropolitan area authorities to lead the transition to a low carbon new mobility era in a sustainable manner. Co-creation labs are established in order for citizens, authorities and industry to design together new mobility and spatial organisation concepts. At the same time, demonstrations with electric AVs, and drones take place to understand in real-life their requirements. Market surveys are organised to elicit people and freight actors' preferences and reactions towards the co-created concepts and the demonstrated new mobility technologies. The HARMONY model suite is designed to assess the multidimensional impacts of the new mobility concepts and technologies. The model suite integrates: 1. land-use models (strategic/long-term), 2. people and freight activity based models (tactical/mid-term), and 3. multimodal network (operational/short-term) models allowing for vertical planning. This integrated approach is necessary for authorities to understand if policies are sustainable, while also contribute to meeting COP22 targets, social equality and wellbeing. The HARMONY model suite is also linked to an EU-wide model to further identify the impact of the concepts and technologies on the TEN-T level. HARMONY's concepts and the model suite are applied and validated on six EU metropolitan areas on six TEN-T corridors: 1. Rotterdam(NL), 2. Oxfordshire(UK), 3. Turin(IT), 4. Athens(GR), 5. Trikala(GR), 6. Upper Silesian-Zaglebie Metropolis(PL). By having six different areas as pilots, we will be able to propose to authorities, spatial and transport planners, concepts and technologies for different types of areas/cities

Keywords: new mobility services,transport planning,spatial planning,transport modelling,travel behaviour,autonomous vehicles,drones
Marine renewable energies in areas beyond national jurisdiction: legal answers to new environmental and governing challenges (RENEWABLE-HIGH-SEAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-04-22
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Roughly 64% of our oceans are marine areas beyond national jurisdiction (ABNJ), i.e. the international seabed area (Area) and the high seas. This extensive area has unparalleled potential for the use of marine renewable energies (MREs) to provide energy security and competitiveness (i.e. creation of jobs and economic development) to the States as well as for the fight against climate change at a global scale. Accordingly, States are becoming increasingly interested in the economic and climate change mitigation potential in ABNJ. At the same time, however, the expansion of MREs into marine ABNJ as well as the environmental impacts associated with their development can entail new risks and threats to security and biodiversity due to the significant regulatory challenges and governance gaps in ABNJ. This project aims to enhance the sustainable development of MREs in ABNJ in a global and European regional context. To achieve this, the project will analyse the ability of the global and European regional regulatory frameworks for the development of MREs and the protection of the environment related to their development in ABNJ, as well as will explore new forms of governance through global energy agencies (IRENA and IEA). As a result, this project will shed light on normative questions related to governance, sovereignty and policy-making considering global and regional forms of governance of MREs in ABNJ, which will significantly contribute to advancing and strengthening the renewable energy and related environmental governance in ABNJ as well as to opening-up discussions and debates on this issue within academics, state officials negotiating the UN treaty for the conservation and sustainable use of marine biodiversity in ABNJ, professionals, the MRE industry and the wider community.

Keywords: marine renewable energies,areas beyond national jurisdiction,law of the sea,environmental law,regional and global governance