Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Circular Cities and Regions Initiative (CCRI) Communities of Practice (CoPs) (CCRI CoPs)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Germany,Belgium,Spain,Netherlands
Call: Enhancing collaboration between Circular Cities and Regions Initiative's (CCRI) supporting organisations (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-07-01
End date: 2026-12-31
Duration (months): 30.0
Total project cost (EUR): 2689714.4
EU funding (EUR): 2498558.15
Participants: 14
Project status: SIGNED

CCRI CoPs' goal is to strengthen and complement the CCRI, in order to foster the implementation of Circular Systemic Solutions (CSS) in European cities and regions. Based on an initial scoping and needs assessment, the project will set up at least eight Communities of Practice – working groups of ambitious European cities and regions collaborating on key topics related to circular economy implementation. The project will also deepen the CCRI knowledge on circular economy, with the production of highly impactful case studies on CSS, a series of white papers on key Research & Innovation (R&I) gaps, guidance documents for practitioners at the local and regional level, as well as recommendations for EU and national policy makers, to unlock barriers faced local and regional authorities. By establishing a series of mechanisms such as capacity building sessions, study visits and a twinning program, the project will stimulate knowledge transfer, pear learning and capacity building towards an audience of cities and regions, including but not limited to CCRI Pilots and Fellows. The consortium will also provide continued support to the CCRI’s Thematic Working Groups (TWGs). All dissemination and communication activities will use the CCRI existing umbrella identity and existing communication channels. The project will endeavour to strengthen links with the European ecosystem and to promote the circular economy towards all European cities and regions. Those activities will be done in close coordination with the CCRI-CSO and DG RTD, to take advantage of potential synergies and importantly to prevent any overlaps and duplications with the work of the CSO. Led by ICLEI Europe, the project brings together 11 leading organisations active throughout Europe and with considerable expertise and experience in supporting cities and regions’ sustainability transition.

Keywords: circular economy,circular systemic solutions,circular economy action plans
Massively parallel joint end-to-end Bayesian analysis of past, present, and future CMB experiments (Commander)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Norway,Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 2
Project status: SIGNED

Detecting inflationary gravitational waves from the Big Bang and mapping cosmic structure formation rank among the most important goals in modern cosmology, and detailed cosmic microwave background (CMB) measurements is a uniquely powerful probe of these effects. However, the predicted signatures are tiny, and their detections require unprecedented instrumental sensitivity and systematics control. In this project I propose to develop one single massively parallel end-to-end framework for the joint analysis of past, present and future CMB experiments, and use this to combine current data from WMAP, Planck LFI+HFI and others with forthcoming measurements from Simons Observatory (SO), all processed at the level of time ordered data (TOD). I will also prepare for the analysis of future CMB experiments, including LiteBIRD, CMB-S4, and a Voyage 2050 CMB spectral distortion probe. This framework will build on an Open Source Bayesian CMB Gibbs sampler called Commander that has already played a transformational role in the field for more than two decades, and that has recently been used successfully to derive new state-of-the-art frequency maps for both Planck LFI and WMAP. However, the existing code only scales well up to O(100) computing cores, and I propose in this project a new organization that will scale it up to O(100,000) cores, as required for next-generation experiments. I will also implement a wide range of ground-breaking TOD-level corrections for key systematic effects (non-linear ADCs, cosmic ray glitches, atmospheric fluctuations, detector cross-correlations etc.) that optimally exploit synergies between experiments. Once operational, I will use this global framework to establish a new state-of-the-art model of the microwave sky; shed new light on several hotly debated LCDM tensions; and, perhaps, make the world's first detection of primordial gravitational waves. This work represents a paradigm shift in the field of computational cosmology.

Keywords: cosmic microwave background,bayesian methods
MemoryRNA: the role of epitranscriptomics in thermomemory regulation (MemoryRNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-12-31
Duration (months): 28.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: TERMINATED

Plants live in constantly changing environments and the increased frequency of extreme weather, as a result of climate change, will exacerbate such stresses. The MemoryRNA project aims to expand the fundamental knowledge of non-genetically-based regulations of the plant transcriptome during heat stress (HS). Post-transcriptional modifications of RNA create an additional layer to reversibly control RNA fate. The sophisticated and poorly understood thermomemory phenomenon represents a powerful system to study the role of the RNA modifications and its high impact on RNA metabolism to reprogram the transcriptome, thus leading plants to adapt and survive. To unravel the role of epitranscriptomic-based reprogramming of the transcriptome of thermomemory RNAs at the shoot apical meristem, the project aims to: i) Reveal the m5C and m6A modifications transcriptome-wide that actively contribute to the global cellular response to HS; ii) Characterize the m5C and m6A marks on thermomemomery mRNAs; and iii) Determine how a m6A reader protein ECT2 is regulated upon HS, and its functional role on transcriptional regulation. Data and biological resources obtained by the team support the MemoryRNA project and incorporate a comprehensive set of cutting-edge technologies and approaches, including: i) Direct sequencing of long-read fragments and computational analysis for accurate mapping of RNA marks; ii) Antibody-based techniques and mutant plants to validate and characterise the function of m5C- and m6A-containing mRNAs; and iii) RNA and fluorescence in situ hybridization, and laser confocal microscopy to investigate the role of ECT2 during thermomemory. Understanding the mechanisms that coordinate transcriptional activity of HS-memory genes in response to environmental stressors is of utmost importance to modern agriculture, and throughout the the funding period, opportunities for translation of our results to biotechnological application will be monitored and explored.

Keywords: epitranscriptomics,rna modification,m5c,m6a,thermomemory,heat stress,shoot apical meristem,stem cell regulators,arabidopsis,thermopriming
The malignant Glioma immuno-oncology matchmaker: towards data-driven precision medicine using spatially resolved radio-multiomics (GLIOMATCH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Belgium,Netherlands,Norway,Spain,Switzerland,United Kingdom,Israel,Germany,Italy,Sweden
Call: Addressing poorly-understood tumour-host interactions to enhance immune system-centred treatment and care interventions in childhood, adolescent, adult and elderly cancer patients. (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 11389958.75
EU funding (EUR): 11389958.75
Participants: 15
Project status: SIGNED

Adult and paediatric malignant glioma (GBM and pHGG) remain among the most difficult-to-treat cancers with 5-year survival rates of <5% despite intensive standard-of-care therapy. The differences among patients and the heterogeneous and plastic nature of each individual tumour have resulted in all therapeutic clinical trials failing during the past 20 years. Recently, immunotherapy has been showing great promise, but only in subsets of patients. Identifying those patients cannot be done a priori as biomarkers are still largely missing, nor are we able to follow-up on therapeutic efficacy when patients get treated. The GLIOMATCH project aims at improving the clinical outcome of GBM/pHGG patients by enabling immunology-based patient stratification to empower personalised matching of appropriate immunotherapy, while improving follow-up of clinical responses to existing/novel therapeutics. This will be achieved by integrating spatially resolved, multi-layered tissue maps (using integrated single-cell multiomics), with non-invasive MRI images. This integration will fuel into a novel MRI Radio-multiomics hub, that will be made available to clinical professionals through which they can perform tumour-host based patient stratification and personalised therapy matching while interpreting longitudinal follow-up and treatment efficacy. The proposed data-driven models will be developed by analysing the largest cohort of immuno-oncology (I/O) treated GBM/pHGG patients (n>300, including pre-post treatment samples) with matched controls (n>300) and exceptionally long-term surviving GBM patients (n~140), in which various tumour-host niches will be studied in how they respond to I/O perturbations and lead to improved clinical outcome. This will be empowered by deploying an UNCAN-compatible data lake, to which incremental data collection will be used to further refine the machine learning models, while proposing novel treatment options. This action is part of the Cancer Mission cluster of projects on “Understanding (tumour-host interactions)".

Keywords: radio multiomics,immunotherapy using dc vaccination,spatial multiomics to map tumour host interactions,glioblastoma,data integration
Accelerating drug repurposing for rare neurological, neurometabolic and neuromuscular disorders by exploiting SIMilarities in clinical and molecular PATHology (SIMPATHIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,France,Germany,Greece,Slovenia,Spain,Portugal,Luxembourg,Canada,United Kingdom
Call: Development of new effective therapies for rare diseases (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 8827970.0
EU funding (EUR): 8826970.0
Participants: 22
Project status: SIGNED

Drug repurposing can fill an important gap for rare disease patient groups with large unmet medical needs. In comparison to traditional drug development, drug repurposing reduces the time and costs for drug development, regulatory approval, and market authorization. Yet, we need to increase the efficiency of the drug repurposing pathway to provide broader access to new therapeutic modalities for larger groups of patients. SIMPATHIC’s main objective is to accelerate drug repurposing for rare neurological, neurometabolic and neuromuscular disorders. SIMPATHIC’s main accelerating innovation is the simultaneous drug development for groups of patients with different genetic diagnoses but overlapping neurological symptoms and molecular pathomechanisms. SIMPATHIC’s key outputs accelerating the drug repurposing pathway include: Standard operating procedures for culturing stem cell-derived neuronal cell models with proven relevance for clinical symptoms and amenable to high-throughput drug screens; New drug repurposing candidates with proven efficacy in advanced brain-on-a-chip and 3D brain organoid models, as demonstrated by reversal of molecular biomarker signatures and cellular readouts associated with clinical symptoms; Designs of innovative basket clinical trials to which patients with different disorders are recruited, utilizing and aggregating personalized clinical endpoints; A training module for patients and patient organizations to empower them as drivers of the drug repurposing pathway; Blueprints for intellectual property strategies, business models, regulatory dossiers and patient access strategies, developed in co-creation between all relevant stakeholders. SIMPATHIC’s proof-of-concept for the simultaneous development of repurposed drugs for multiple indications will show the path forward to development of personalized treatment opportunities for groups of rare disease patients in a cost- and time-efficient manner.

Keywords: drug repurposing,organoids,innovative clinical trials,artificial intelligence,patient registries,patient access,fair data
Quantum Enhanced Sensing with Trapped ions for Atomic Parity Violation (QuEST for APV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1968875.0
EU funding (EUR): 1968875.0
Participants: 1
Project status: SIGNED

The Standard Model (SM) of particle physics classifies the known particles and describes their non-gravitational interactions extremely well. However, it fails to provide answers to various big open questions, such as the origin of dark matter. The QuEST project aims to break new ground in fundamental physics by probing the electroweak (EW) sector of the SM. The weak force is the only fundamental interaction that is known to break spatial mirror symmetry known as parity. In atomic systems, parity violation provides a unique window into electroweak interactions at low energies, complementary to high energy particle physics. However, the signals stemming from atomic parity violation (APV) are incredibly weak and, for the last two decades, progress on low-energy EW tests have been hampered by the daunting experimental requirements to detect APV. In this proposal, I fully exploit the quantum toolbox to reveal APV in Ba+ for the first time. The employed method is based on a pair of Ba+ ions in a quantum-entangled state that is by design insensitive to correlated noise and immune to common-mode systematic effects. This significantly eases the experimental requirements and enables a measurement of APV with a superior accuracy. The main outcome of QuEST is to provide a first independent precision low-energy test of the electroweak sector of the SM in nearly 20 years. The targeted level of accuracy will go beyond the current state-of-the-art and will allow for sensitive search for new physics beyond the SM, where QuEST will probe for processes at an energy scale of up to ~10 TeV. The results will provide information on nuclear structure, relevant for astrophysics, and will impact the field of quantum information science. Therefore, QuEST is a unique platform with an interdisciplinary character that will shape the landscape of low-energy electroweak tests of the SM for many years to come.

Keywords: cold trapped ions,entangled decoherence free states,electroweak interactions,parity violation,quantum metrology,new physics beyond the standard model
Stem cell riboregulation: a new layer to control self-renewal, differentiation and metabolism (SCRIBE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Although multiple regulatory layers have been reported to control stem cell differentiation, including epigenetics, cell signaling and metabolism, we still lack sufficient knowledge on how differentiation processes are connected and coordinated. The Hentze laboratory recently discovered that RNA modulates (riboregulates) the activity of the glycolytic enzyme Enolase 1 (ENO1) and that this interaction is essential for in vitro murine embryonic stem cell differentiation. Additionally, unpublished data from the laboratory show that the glycolytic enzyme pyruvate kinase (PKM) is also riboregulated. However, the role of riboregulation during primary stem cell differentiation remains elusive. Previously, RNA-bound proteomes have either been identified in cultured cells or ex vivo in whole organs. I aim to investigate enzyme-RNA interactions in primary stem cells and differentiated progeny, using the hematopoietic system as a model. First, I will analyze the RNA-binding activity of previously in cellulo profiled enzymes ENO1 and PKM in vivo and ex vivo during hematopoietic stem cell (HSC) differentiation by RNA-proximity ligation assays, profiling of stem cell activity and transcriptome analysis (aim 1). Secondly, I will analyze, identify and comparatively quantify global RNA-protein interactions in HSCs, progenitors and mature blood cells by developing a method to profile in vivo RNA-protein interactions (aim 2). In an interdisciplinary approach, I will pair fluorescence-activated cell sorting with state-of-the-art RNA-protein cross-linking approaches and ultra-low input proteomics analysis. The generated data will help, for the first time, to understand at the analytical and functional level whether and to what degree riboregulation of enzymes represents a regulatory paradigm operational in mammalian cells, with a focus on hematopoietic stem cell differentiation.

Keywords: rna biology,rna protein interaction,riboregulation,metabolism,glycolysis,stem cell,differentiation,cancer
Synthetic antibody (SynAb) receptors for the detection and isolation of cyclic depsipeptide (CDP) toxins in food samples (SynAb4Toxin)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

Food safety plays a critical role in society. When it comes to avoiding food poisoning, most of the attention goes to preventing microbial growth in food products. However, the cause of intoxication is the presence of toxins produced by these microorganisms. Yet, standard industrial or household food processing and preparation techniques effective at removing the producing microorganisms fail to remove the actual toxins. As a result, these toxins, which typically are not detected in routine microbial food analysis, are consumed daily by the general population. Beauvericin (BEA) and enniatin B (ENN B) are mycotoxins produced on crops that can easily end up in the final food or feed products. Other examples include cereulide (CER), which is produced by bacteria and has a high prevalence in ready-to-eat foods. Multiple consequences and even fatalities have been reported due to the consumption of food contaminated with BEA/ENN or CER and as such, the detection and sequestration of these toxins is of utmost importance, both in public health and economic terms, as well as from a broader stakeholder perspective. Despite numerous attempts worldwide, the current state of the art does not allow the production of antibodies against CER, BEA or ENN B via classical animal immunization. This hampers the creation of a fast, robust, inexpensive and on-field (kit-based) detection system for these toxins in food commodities. In the current project, I intend to use artificial synthetic antibodies (SynAbs) that bind to these toxins (ionophoric cyclic depsipeptides) to produce valuable technologies for detecting and isolating these toxins in complex food samples.

Keywords: food safety,mycotoxins,bacterial toxins,affinity reagents,elisa,lfa,spe
The Role of Complexity in Decision-Making (Complexi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 149365.2
EU funding (EUR): 149365.2
Participants: 1
Project status: SIGNED

This research proposal investigates the multifaceted role of complexity in decision-making and social preferences through a series of survey experiments. By examining how narrative complexity, task complexity, and social complexity influence individual choices and behaviors, the study aims to uncover the mechanisms by which complexity affects decision-making processes. The experiments will simulate realistic environments, such as online shopping and economic games, to provide empirical insights into how people navigate complex scenarios. The project will specifically explore whether complexity drives individuals towards default and heuristic-based decisions or rather increases noise in decisions, leading to suboptimal choices in either case. Additionally, it will investigate how accountability and narrative framing can mitigate or exacerbate the effects of complexity. By understanding these dynamics, the research aims to provide actionable insights for improving communication strategies, enhancing consumer decision-making environments, and fostering cooperative behaviors in social and economic contexts.

Keywords: behavioral economics,experimental economics,complexity,narratives,decision making,survey experiments