Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MEMBRANE PROTEINS OF ELECTROACTIVE BACTERIA PROBED AT LIPID LAYERS ONTO MODIFIED ELECTRODES (MELBA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-07-22
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

MELBA aims at developing an efficient and versatile electrochemical platform for probing the charge transfer properties, electronic or protonic, of membrane proteins extracted from Gram negative electroactive bacteria. This 2 years research project will be conducted at the Université de Rennes 1, UR1 France, including a six months Secondment at Universidade Nova de Lisboa, UNL Portugal. Carbon electrodes will be covalently modified with pH-responsive electrophores through surface modification techniques, WP1 Task1. Lipid layers will be deposited onto the modified electrodes to create an artificial membrane as a host for extracted membrane proteins, WP1 Task2. The experienced researcher Dr. Lebègue will learn protein expression, extraction, purification and characterization during the six months Secondment at UNL, WP2 Task3. Finally extracted proteins will be incorporated into the artificial membrane deposited onto the modified electrodes and their electronic and/or protonic charge transfer properties will be characterized, WP2 Task4. The ambition of MELBA is to understand the coupling of extracellular electron transfer with proton transport in Gram (-) electroactive bacteria. The outcome of MELBA will be useful to optimize potential microbial electrochemical technologies based on electroactive bacteria and will be applied to the characterization of the charge transfer properties of any membrane protein. Within MELBA, 3 oral communications will be given at international conferences, 5 high impact papers will be published in the field of bioelectrochemistry and 5 formal public engagement actions have been scheduled. MELBA will allow Dr. Lebègue to develop and extend her expertise in electrochemistry, materials science and surface modification to microbiology and biochemistry. Dr. Lebègue will enter the field of microbial electrochemistry and acquire a unique and solid interdisciplinary profile, required to compete for permanent academic positions and grants in Europe.

Keywords: electrochemistry carbon surface chemistry lipids artificial membrane electroactive bacteria exocellular electron transfer membrane proteins redox proteins ion transport proteins
Design of 2 Technologies and Applications to Service (D2Service)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Germany,Italy,Germany,Belgium,Denmark,United Kingdom
Call: Significant improvement of installation and service for fuel cell systems by Design-to-Service (H2020-JTI-FCH-2014-1, 2014)
Start date: 2015-09-01
End date: 2020-03-31
Duration (months): 55.0
Total project cost (EUR): 3636797.5
EU funding (EUR): 2953790.75
Participants: 8
Project status: CLOSED

The Design 2 service project aims at simplifying both residential and commercial fuel cell systems for easy, fast and save system service and maintenance. In order to make best use of lessons learned and available resources, this project jointly works on two distinguished technologies (PEMFC and SOFC) in two different markets (residential & extended UPS). Both SME manufacturers are committed to establish lean after-sales structures, a significant step towards mass manufacturing and deployment. Maintenance is one significant part of Total Cost of Ownership of FC systems. Pooling the operational experience of field test programs, such as ene.field and Callux, critical analysis will lead to a priority list of required technical changes. For cold Balance of Plant Components, joint efforts will focus on the desulphuriser and the water treatment system. Actions are taken for both simplified maintenance and extended durability for prolonged service intervals. Logistics for replacement component supply will be considered. For the hot component parts, the manufacturers work on their individual hot topics to adapt and simplify the design of the current units, e.g. to allow replacement of individual components instead of sub-units. A large decrease of costs impact is expected once individual stacks can be changed in a simple maintenance operation instead of complete sub-units. It is important that such operations can be performed by a significant pool of qualified installers. This is addressed by the elaboration of simple technical manuals that will be exposed to real-life practical technicians in training programs. These actions aim at decreasing the technical barrier to service systems. Finally, the improved BoP units will be validated by testing single and multiple units. Beyond the classical features of high efficiency and silent operation, this will also add values like flexibility and modularity of FC technologies with respect to individual customer requests.

Keywords: design to service,components and life time optimization,decreasing down time
Simultaneous Vision Simulator for optimizing selection of presbyopic correcions (SimVisSim)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-07-01
End date: 2017-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The lost of the eye’s capability to accommodate near and far objects (known as presbyopia) affects 100% of the population >45, i.e. 200 million in Europe and 1.200 million worldwide. Multifocal corrections, in the form of contact lenses (CLs), intraocular lenses (IOLs) or corneal surgery are increasingly used solutions to restore vision functionality in presbyopes. These corrections are based on the simultaneous vision principle, where a focused image and a defocused image are simultaneously projected on the retina. How a simultaneous image looks like is difficult to imagine. To date, prescription of a multifocal correction is based on the surgeon’s experience and conversations with the patient. In CLs solutions, the process requires multiple trials and errors with different lenses. In cataract surgery, patient’s unsatisfaction often results in IOL explantation. The PRESBYOPIA ERC-Advanced Grant investigates basic mechanisms of the crystalline lens accommodation, to propose nature-inspired designs to correct presbyopia, multifocal lenses in particular. We have developed Adaptive-Optics visual simulators to simulate corrections before they are manufactured or implanted in a patient. In particular, we have developed novel simultaneous vision simulators (an optical bench instrument, and a see-through portable clinical prototype) that allow patients to see the world under programmed multifocal IOLs. We have demonstrated their capabilities to mimic commercial multifocal designs, visual performance with different design parameters and neural adaptation to simultaneous vision. The SimVisSim ERC-Proof of Concept will evaluate the marketability of the SimVis Technology, generating new IP, develop a technology transfer strategy, and a product commercialization plan, with the ultimate goal of deploying a clinical device in the market. This should bring eye surgery and presbyopia treatments into new paradigms for lens selection and customization.

Keywords: simultaneous vision,neural adaptation,intraocular lens designs,presbyopia,crystalline,optical bench instrument
Analysis of the nucleolus in genome organization and function (NucleolusChromatin)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In eukaryotic cells, the higher-order organization of genomes is functionally important to ensure correct execution of gene expression programs. For instance, as cells differentiate into specialized cell types, chromosomes undergo diverse structural and organizational changes that affect gene expression and other cellular functions. However, how this process is achieved is still poorly understood. The elucidation of the mechanisms that control the spatial architecture of the genome and its contribution to gene regulation is a key open issue in molecular biology, relevant for physiological and pathological processes. Increasing evidence indicated that large-scale folding of chromatin may affect gene expression by locating genes to specific nuclear subcompartments that are either stimulatory or inhibitory to transcription. Nuclear periphery (NP) and nucleolus are two important nuclear landmarks where repressive chromatin domains are often located. The interaction of chromosomes with NP and nucleolus is thought to contribute to a basal chromosome architecture and genome function. However, while the role of NP in genome organization has been well documented, the function of the nucleolus remains yet elusive. To fully understand how genome organization regulates chromatin and gene expression states, it is necessary to obtain a comprehensive functional map of genome compartmentalization. However, so far, only domains associating with NP (LADs) have been identified and characterized while nucleolar-associated domains (NADs) remained under-investigated. The aim of this project is to fill this gap by developing methods to identify and characterize NADs and analyse the role of the nucleolus in genome organization, moving toward the obtainment of a comprehensive functional map of genome compartmentalization for each cell state and providing novel insights into basic principles of genome organization and its role in gene expression and cell function that yet remain elusive.

Keywords: nucleolus,nuclear periphery,genome architecture
GNSS Automated Virtualized Test Environment for RAIL (GATE4RAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Italy,Italy,Belgium,Belgium,France,France
Call: Modern methodologies and verifications for GNSS in Railways and virtual test environment (H2020-S2RJU-OC-2018, 2018)
Start date: 2018-12-01
End date: 2021-02-28
Duration (months): 27.0
Total project cost (EUR): 1019993.75
EU funding (EUR): 1019993.75
Participants: 10
Project status: CLOSED

GNSS Automated Virtualized Test Environment for Rail (GATE4Rail) deals with tasks TD2.4 and TD2.6 of the Shift2Rail Multi Annual Action Plan with the goals to: i) achieve a realistic characterization of the GNSS in the railways environment assessing the performance and properties of typical fail-safe train positioning components in nominal and fault conditions; ii) implement a common test process framework for zero on-site testing to minimizing cost and time. GATE4RAIL will implement a geo-distributed simulation and verification platform connecting GNSS centres of excellence, and ERTMS/ETCS laboratories to evaluate the GNSS performances in the railway environment with agreed methodologies and tools. This approach offers the advantage to stress the global system in presence of very rare fault events instead of long and expensive tests on field, developing a standard methodology for representative test cases. GATE4RAIL will develop methodology and tools for an automated update of tests, through Model-Based System Engineering philosophy to ensure that the simulation infrastructure can be maintained and extended reducing the need for re-assessments to increasing the test environment efficiency. The entire process will be reviewed by an independent Notified Body already engaged on GNSS assessment for rail applications and a demo on railway line in Italy and Spain is included. GATE4RAIL’s team is very competent bringing together expertise on the GNSS and rail sectors necessary for the exploitation of GNSS that is one of the Game changer of the ERTMS.

Keywords: gnss characterization,automated tests,railway,simulation infrastructure,geo distributed,zero on site testing,cost reduction
Emotional Acculturation: Emotions as Gateways to Minority Inclusion (EMOTIONACCULTURATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Belgium,United States
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 2499579.0
EU funding (EUR): 1809811.5
Participants: 2
Project status: SIGNED

International migration has often been referred to as one of the major challenges of the 21st century. Numbers of immigrants have been increasing, but social integration of migrants and their children is lagging at the detriment of immigrant minorities themselves and often resulting in conflict within receiving societies. EmotionAcculturation investigates the role of emotions, as key processes of interaction, for immigrant minorities’ social inclusion, and their wellbeing. It builds on research showing that, in each culture, emotions are socialized to fit the most valued kinds of relationships, and that the prevalent emotions, therefore, vary across different cultures. I postulate that misfit of the emotions of immigrant minorities with the typical majority emotions compromises interactions, and that this will hamper their social integration, and therefore their opportunities in the larger society. I study how and when emotional acculturation forms an important gateway to the social inclusion and wellbeing of immigrant minority individuals. The grant is organized around three Objectives: to better understand 1) the nature of emotional acculturation, 2) its conditions, and 3) its outcomes. I adopt a multi-method approach, following large numbers of immigrant minority and majority participants over time, in their everyday lives, and in real-time interactions in the laboratory. The project will span two receiving national contexts with different diversity climates (Belgium, California). It will shed light on understudied micro-processes involved in minority inclusion, and their social and health consequences. EmotionAcculturation offers a novel approach to psychological acculturation that goes beyond attitude change. Moreover, by studying emotional change beyond childhood, it also contributes to our understanding of how emotions are constructed through relational engagements, and how they facilitate social coordination and cohesion.

Keywords: acculturation
MEchanisms and PHysical processes governing Induced Seismicity: insights from Theoretical models and seismological Observations (MEPHISTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Over the last decade induced seismicity became an important topic of discussion both at scientific and societal level. Industrial activities altering the state of stress or the pore pressure of the shallow crust may, in fact, generate seismicity which can be felt by the population, reducing the public acceptance of such activities. The physical connection between operational parameters such as injected (or extracted) volume and the induced seismicity is complex and not yet fully understood. A better understanding of the influence of fluid injection/extraction parameters on the potential failure of pre-existing faults nearby the reservoir is furthermore a fundamental step towards the management of the hazard posed by induced earthquakes. The project MEPHISTO aims to a get insights into the physical processes governing induced seismicity, strengthening the link between seismological observations and geomechanical models. To pursue this scope the project is organized in two complementary work packages (WPs): in the WP1 we plan to develop/improve innovative full-waveform seismological methods for microseimicity characterization, allowing to obtain larger and more reliable seismic catalogues. WP1 aims to retrieve, using innovative full-waveform based methods, a detailed knowledge of the geometry of active faults and stress state within the reservoir. These informations are fundamental for the setup of the geomechanical model. In the WP2 we will use a geomechanical modeling based on fluid flow modeling in poroelastic media and coulomb stress changes to simulate induced seismicity in relation to different geomechanical scenarios. The comparison of the obeserved seismicity with the simulated one will be then used to calibrate geomechanical model and to investigate the influence of underground industrial activities on the generation of induced seismicity. To accomplish the project goals a high datasets related to different case studies will be assembled.

Keywords: induced seismicity,microseismic monitoring,geomechanical modeling
Development of Direct Dehydrogenative Couplings mediated by Dioxygen (2O2ACTIVATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1489822.5
EU funding (EUR): 1080832.76
Participants: 2
Project status: CLOSED

The field of C-H bond activation has evolved at an exponential pace in the last 15 years. What appeals most in those novel synthetic techniques is clear: they bypass the pre-activation steps usually required in traditional cross-coupling chemistry by directly metalating C-H bonds. Many C-H bond functionalizations today however, rely on poorly atom and step efficient oxidants, leading to significant and costly chemical waste, thereby seriously undermining the overall sustainability of those methods. As restrictions in sustainability regulations will further increase, and the cost of certain chemical commodities will rise, atom efficiency in organic synthesis remains a top priority for research. The aim of 2O2ACTIVATION is to develop novel technologies utilizing O2 as sole terminal oxidant in order to allow useful, extremely sustainable, thermodynamically challenging, dehydrogenative C-N and C-O bond forming coupling reactions. However, the moderate reactivity of O2 towards many catalysts constitutes a major challenge. 2O2ACTIVATION will pioneer the design of new catalysts based on the ultra-simple propene motive, capable of direct activation of O2 for C-H activation based cross-couplings. The project is divided into 3 major lines: O2 activation using propene and its analogues (propenoids), 1) without metal or halide, 2) with hypervalent halide catalysis, 3) with metal catalyzed C-H activation. The philosophy of 2O2ACTIVATION is to focus C-H functionalization method development on the oxidative event. Consequently, 2O2ACTIVATION breakthroughs will dramatically shortcut synthetic routes through the use of inactivated, unprotected, and readily available building blocks; and thus should be easily scalable. This will lead to a strong decrease in the costs related to the production of many essential chemicals, while preserving the environment (water as terminal by-product). The resulting novels coupling methods will thus have a lasting impact on the chemical industry.

Keywords: radical coupling reaction,c h activation,cross dehydrogenative coupling,o2 activation,c n bond formation,oxidative amination
Amphiro en-Gage: Technology for a Smart and Sustainable Use of Hot Water (Amphiro en-Gage)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Switzerland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2018-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Product: Amphiro has developed the first energy-autarkic, micro-mechatronic modules that measure, communicate and display hot water consumption in real-time and at the point of use. The modules are powered by water flow, fit to virtually every water outlet and can be retrofitted by end-users or integrated by faucets OEMs. The patented technology helps to monitor personal energy and water use, motivates a sustainable behavior and allows faucet OMEs to add digital features to their products. Value to the customer: The first derived product, a consumption feedback-device for showers, has been piloted in 3500 households for the Swiss Federal Office of Energy and the Public Utilities Board (Singapore). It achieves average savings of 440 kWh of heat energy and 7500 l of water per household and year, pays for itself in less than 9 months and earns the user 110 EUR per year thereafter. The pilot study results were named Highlight in Nature Energy. Target customers: Amphiro will address a niche market of environmentally aware and technology affine customers (11% of households), supply products to efficiency campaigns and deliver components for the digitalization of drinking water systems. Lead customers: Amphiro won several large pilot customers, incl. utility PWN (NL), ewz (CH), Public Utilities Board (SG), Melbourne Water (AU), Alicante (ES), plus 9 hotels in Europe. Feasibility assessment: Core objective of this project is to empirically investigate by means of actual sales tests the market feasibility of digital services that accompany the modules and probe four variations of a business model, empirically determine market size and first target segment and derive a well-founded business plan for phase 2. European/global dimension: The mid- to long-term objective is to reach a market penetration of 5% of all European households, which is ambitious yet realistic given the existing market response in terms of sales and the excellent standardization of water outlets.

Keywords: smart faucets,efficient use of hot water,consumption feedback