Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Balancing Act: Understanding metabolic regulation via the acetyltransferase MOF during Drosophila embryogenesis (MetaMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

The risk of prenatal onset of metabolic disorders is influenced by the maternal environment, which is inherited by the offspring through epigenetic modifications. Epigenetic modifications utilize metabolic substrates, highlighting the connection between epigenetics and metabolism. In Drosophila, one key epigenetic modification is the MOF-mediated acetylation of histone H4 at lysine 16 (H4K16ac), which is known to be intergenerationally transmitted from mother to embryo. This makes Drosophila an ideal model to study how maternally contributed epigenetic modifications and metabolites shape embryonic development. MOF operates in two modes: maternal pools establish chromatin accessibility, while zygotic pools facilitate future gene activation. Given that embryonic metabolism is temporally coordinated during development, the role of epigenetic regulation in embryonic metabolism remains unexplored. To address this, I plan to investigate the temporal contributions of MOF in metabolic regulation during Drosophila embryogenesis. Specifically, the following aims will be undertaken: Aim 1: Understand the maternal contributions of MOF-mediated metabolic regulation. Aim 2: Investigate the zygotic contributions of MOF in metabolic regulation. Aim 3: Uncover the association of MOF with the MSL or NSL complex to provide a mechanistic basis for metabolic regulation. These aims will be achieved through a combination of cutting-edge techniques involving metabolomics, RNA-sequencing, and epigenomics. This research will provide insights into metabolic regulation during early development and its implications for maternal impacts on offspring metabolism. The findings will enhance our understanding of the fundamental mechanisms underlying the epigenetic basis of metabolic regulation, with broader implications for developmental biology and disease.

Keywords: mof,h4k16ac,zygotic genome activation,embryogenesis,metabolism,transcription
AstroPhysical searches for Axions in the RAdio and X-ray bands (APARAX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-12
End date: 2029-01-11
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 2
Project status: SIGNED

Dark matter is a mysterious fluid that permeates our Universe, driving the motions of stars and galaxies. Axions and axion-like particles are favorite candidates that could solve the outstanding puzzle: What is dark matter made of? APARAX will tackle this question by predicting signals of the presence of these particles in a range of astrophysical environments, from stars to galaxies. The predictions will be tested against upcoming and archival data using a multiwavelength approach, focusing on the radio and X-ray bands. The innovative techniques and software tools developed will become a benchmark for future searches. Thanks to the rich training and outreach program, APARAX will positively impact the researcher's scientific and personal growth, as well as society, bringing the public closer to science.

Keywords: axions,axion like particles,astroparticle physics
Step Change in Recycling Unrecyclable Plastic Waste - A Tandem Route for Circular Economy (OCEAN-RE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Poland,Ireland,Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 6
Project status: SIGNED

The OCEAN-RE project aims to address the pressing issue of marine plastic waste and promote a sustainable circular economy in Europe. Led by a talented researcher, the project adopts a multidisciplinary and intersectoral approach to develop innovative chemical recycling technologies to effectively convert marine plastic waste into valuable platform chemicals. Through four work packages, the project will investigate hydrothermal treatment as a pre-treatment step, optimize a tandem catalytic process for propene and BTX production, and conduct a life cycle assessment and techno-economic analysis to evaluate the process's sustainability and profitability. The successful implementation of the OCEAN-RE project will not only enhance the Fellow's academic competencies and research skills but also promote a sustainable and circular economy in Europe through effective plastic waste management.

Keywords: plastic waste,circular economy,marine litter
Crystallisation towards efficient and sustainable biomanufacturing (PROCRYSTAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal,Belgium,Bulgaria,France,Spain,Italy,United Kingdom,Hungary
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 3510765.26
EU funding (EUR): 3285662.4
Participants: 17
Project status: SIGNED

Downstream processing (DSP) of biopharmaceuticals is dominated by chromatographic steps which suffer from low throughput, poor scalability and elevated energy consumption, as well as high equipment and materials costs. To this is added the low stability and high degradability of liquid formulations. The training program "Crystallisation towards efficient and sustainable biomanufacturing" (PROCRYSTAL) vision is that of crystallisation as a simple, sustainable, cost-efficient and scalable alternative to current DSP techniques and liquid formulations, once it allows to separate, purify and stabilise in a single step. Nevertheless, integrated training to exploit biocrystallisation full potential is currently not available, only fragmented research activities. Within this training program, 13 Doctoral candidates (DCs) are expected to go beyond current practise to respond to the near future biopharma manufacturing needs. And only possible leveraged by the expertise conveyed in this consortium on biomolecules crystallisation, biochemistry, chemical and process engineering as well as advanced modelling. The PROCRYSTAL training program for the DCs has been framed with special attention to fundamental understanding of the underlying phenomena, from the molecular scale to process scale, and advanced experimental and modelling techniques specific to crystallisation technology. The DCs will acquire a wide range of subject specific and general transferable skills, in an interdisciplinary and inter-sectoral environment and by multinational collaboration which enhances the early-career DCs long term employability and competitiveness.

Keywords: crystallisation biomolecules biopharmaceuticals downstream processing sustainability
Pushing the Frontier of Heterogeneous Agent Macro: Expectations Formation and Economic Crises (HA-FRONTIER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2498431.0
EU funding (EUR): 2498431.0
Participants: 1
Project status: SIGNED

One of the key developments in macroeconomics research over the last three decades has been the incorporation of explicit heterogeneity into models of the macroeconomy. But one of the all-time biggest questions in macroeconomics has so far been out of reach for this approach: why do developed economies experience infrequent but large economic crises? This is due to a problematic feature of current heterogeneous agent (HA) models: the assumption of rational expectations means that agents forecast prices by forecasting distributions resulting in the entire cross-sectional distribution entering their decision problem. This extreme version of the curse of dimensionality hugely increases the models’ computational complexity. HA-FRONTIER aims to overcome this problem by developing alternative approaches to the rational expectations assumption. I will adapt ideas from the literature on reinforcement learning in psychology and computer science (temporal difference learning) to better model how agents form expectations about future prices. I will incorporate key empirical evidence on expectations formation, e.g. from the large literature on survey expectations. Departing from rational expectations thus “kills two birds with one stone”: it makes HA models with aggregate risk operational while, at the same time, making them more realistic. Finally, I will put this methodology to use to develop an empirically grounded macroeconomic theory of infrequent but large economic crises that incorporates asset-price booms driven by individuals reallocating their portfolios toward bubbly assets and crashes driven by the reverse movement. To disseminate the ideas developed by HA-FRONTIER, I will write a PhD-level textbook on heterogeneous-agent macroeconomics. Such a textbook is currently missing, thereby creating unnecessary entry barriers for junior researchers, practitioners, and policy makers.

Keywords: heterogeneous agents,inequality and macro,non rational expectations,reinforcement learning,survey expectations,economic crises,booms and busts
Fostering Linguistic Capital: A Roadmap for Reversing the Diversity Crisis and Activating Societal Benefits in Europe (FOSTERLANG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Poland,United Kingdom,Austria,France,Germany,Spain,Ireland,Norway
Call: Strategies to strengthen the European linguistic capital in a globalised world (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2999815.0
EU funding (EUR): 2999815.0
Participants: 14
Project status: SIGNED

The FOSTERLANG project aims to have a transformative effect on how minoritised languages are protected, used and promoted in Europe in the context of the competitive societal dynamic between dominant and non-dominant languages. This will be achieved by developing evidence-based diagnostics of the minority-language condition and by suggesting strategic and technologically informed initiatives to protect and enhance their socio-economic position. The project consortium brings the cross-cultural, multidisciplinary expertise of 14 participating organisations in an ambitious partnership of intellectual enquiry on key societal aspects of protecting the EU linguistic diversity. Its members combine strengths and expertise in sociolinguistics, social anthropology, education and pedagogy, language planning, digital innovation, computer science, public policy and language revitalisation. The partners will work in tandem to develop a new societal and institutional dispensation by which minoritised language communities will catalyse their contested linguistic capital to counteract the socio-political and economic forces which continue to undermine a sustainable future for Europe’s linguistic minorities and migrants. The work packages are centred on fostering linguistic capital not only from the perspective of protecting Europe’s multicultural diversity, but also to indicate how linguistic capital can enhance other components of human capital, such as economic, demographic and health-related well-being. The project aligns with strategic priorities of EU and the Horizon Europe programme in fostering societal coherence of different linguistic communities living in their shared spaces. The major outcome will be a Linguistic Capital Road Map which will set out a substantive set of recommendations for the short, medium and long-term on effective and meaningful strategies for fostering Europe’s linguistic capital and for safeguarding grassroots multilingualism.

Keywords: language capital,minority languages,linguistic diversity,multilingualism,social capital,social justice
Archaea for Human Health (ArcHealth)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Beside Bacteria and fungi, Archaea, the "third domain of life" have been described as a stable component of the human microbiome. Yet, only few archaea have so far been isolated from humans. The project aims to demonstrate that a fundamentally new product, derived from archaea, revolutionizing current standards of treatments for human health, can be developed from our initial breakthrough achievement, the cultivation of these archaea. The benefits of using archaea derived from human bodies, promise a sustainable, safe and beneficial treatment in the future.
Fuelling the Future: Advancements in Trifunctional Catalysts for Renewable Biofuel Synthesis (ADVENTUROUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

The ADVENTUROUS project, harmonizes with the European Green Deal's 2030 climate targets and the broader EU ambition of reaching carbon neutrality by 2050. It is firmly rooted in the pursuit of catalytic trifunctional systems for the transformative synthesis of sustainable advanced fuels (SAF) derived from renewable feedstocks. The crux of this endeavour rests upon the innovation of two core facets: the integration of catalysts that can seamlessly host diverse catalytic sites and the genesis of an entirely novel synthetic avenue for the production of sustainable aviation fuels (SAF). This project sets forth on a path towards sustainable development, poised to chart a course marked by a near-zero emission CO2 cycle. ADVENTUROUS leverages the expertise of Dr. Camilla Maria Cova in organic synthesis and green synthesis, complemented under the supervision of Prof. Svetlana Ivanova, with broad experience in multifunctional heterogeneous catalysis at the University of Seville (USE). The fruit of this necessary collaboration will be the advanced design and application of a multifunctional catalyst able to revolutionize the biofuel synthesis. What is more advanced technologies such as ultrasound-assisted reactions will be tested for an environmentally sustainable catalyst production and the success of the project will opens a completely new pathways not only to SAF production but also to a numerous starting molecules for fine chemical synthesis. ADVENTUROUS is aligned with the MSCA Green Charter, emphasizing environmental responsibility and sustainable development. By developing sustainable biofuels and innovative catalysts, it contributes to achieving the objectives of decarbonization, energy efficiency, and increased use of renewable energy sources in the transportation sector. Moreover, it addresses key challenges of the current energy landscape, as supply scarcity and environmental pollution, by exploring alternative and renewable pathways for fuel production.

Keywords: biomass biofuels hydrogenation hmf hydrotalcite valeric acid
Strengthening Research in Armenia for Energy Transition toward Climate Solutions (STREACS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Armenia,Ireland,Italy
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1578273.21
EU funding (EUR): 1492507.5
Participants: 7
Project status: SIGNED

A key tenet of the European Green Deal (EGD) is to build clean and renewable energy capacity as a key step toward decarbonisation while providing energy security. Planning and implementing the transition to a decarbonized, sustainable, and resilient energy regime is a complex technical, social, political, and economic process. In the case of Armenia, its landlocked and tense geopolitical position in the South Caucasus adds to the complexity of its energy transition efforts. STREACS aims to enhance the research capacity in Armenia to support the country’s efforts to accelerate its energy transition toward clean and renewable energy sources, while enhancing its energy security. Importantly, such enhanced capacity will also enable Armenia to become better integrated into and a more productive actor in the European Research Area. STREACS will facilitate the transfer of knowledge, exchange of best practices, and inclusion in domain-specific academic networks from research institutions and partners in the EU.

Keywords: energy transition,renewable energy,clean energy,climate change,european green deal,research excellence
pan-European Management of Biological toxin incidents through standaRdisAtion initiatives for Crisis response Enhancement (EMBRACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Netherlands,Cyprus,Belgium,Czechia,Slovakia,United Kingdom,Austria,France,Finland,Japan,Hungary,Germany
Call: Operability and standardisation in response to biological toxin incidents (HORIZON-CL3-2023-DRS-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 5620216.25
EU funding (EUR): 5620216.25
Participants: 18
Project status: SIGNED

Biotoxins pose significant challenges to current crisis management approaches. Existing concepts of operation, derived from Chemical, Biological, Radiological and Nuclear doctrines, and Union Civil Protection Mechanism initiatives, do not address the distinctive and highly complex attributes of a biotoxin crisis. EMBRACE aims to improve Europe’s capacity to respond effectively to biotoxin incidents. We will consolidate and apply scientific and clinical knowledge of biotoxins to revise response protocols and deliver innovative solutions specifically tailored to address gaps and needs identified in current provision. Highlights include analysis of biotoxins not previously addressed in this context, risk-based recommendations for PPE and novel decontaminants, in vitro studies to identify human biomarkers of exposure, novel samplers, portable biosensors and field diagnostics devices, and software tools to assist responders in biothreat risk assessment. To ensure intersectoral and cross-border interoperability of these solutions and successful commercialisation of our exploitable assets, we will prioritise a carefully planned standardisation and valorisation programme. EMBRACE will engage with existing initiatives and projects to create a vibrant biotoxin knowledge network; a multi-sectoral community of stakeholders, on the basis of which a sustainable Biotoxin Task Force will be established as a source of expertise and guidance on biotoxin incidents both for EMBRACE and the wider community. The network of stakeholders and EMBRACE’s ambitious programme of scientific, technological, and operational advances will be supported by the creation of a biotoxin reference and stakeholder hub designed to facilitate knowledge exchange and provide users with direct access to widely distributed and expertise. Finally, EMBRACE’s innovative sustainability strategy will ensure that its solutions and the biotoxin community continue to thrive beyond the duration of the project.