Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ENZYMATIC SO2 BIOSENSOR FOR RAPID FOOD SAFETY MONITORING (SO2SAFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-2-2015, 2015)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 1062235.0
EU funding (EUR): 743564.5
Participants: 1
Project status: CLOSED

Sulphites are food additives that have antioxidant and preservative properties, but are recorded as allergens by the main international regulatory bodies on food safety because of their adverse health effects. Hence, sulphites maximum concentration levels in foodstuff are regulated, and must be ensured by the agro-food processing industries. BIOLAN has developed at the laboratory scale a simple, reliable and specific enzymatic biosensor for sulphite determination and has obtained relevant data that support the innovative project here proposed. Main objective of SO2SAFE project is to develop a novel miniaturized ready to use biosensor based on disposable screen printed electrodes for determination of sulphites in crustaceans, since this is a type of food where the sulphite is broadly used. The novel solution will have a direct impact not only in the food industry economy, but also in the society due to the direct impact the sulphite has in health. Therefore, SO2SAFE project will also contribute to one of the societal challenges set by the European Commission, food safety and consumer health. Specific objectives will be: • To develop further the biosensor prototype to achieve a new miniaturized ready to use biosensor enabling a highly sensitive, selective, fast and user friendly method for determination of sulphites in crustaceans • To demonstrate the SO2SAFE miniaturized biosensor improved performance by relevant stakeholders • To scale-up the biosensor manufacturing process to optimize production cost and increase production capacity SO2SAFE biosensor solution is targeted to all agro-food industries where sulphites are used as additives at different steps of the supply chain. Current methods and tools widely used for sulphite level monitoring in the agro-food industry and in the crustacean industry, are not solving the problem of the high quality control standards required to comply with new regulation on food safety and consumer health protection.

Keywords: biotechnology,biosensor,enzymatic,sulphite,food safety,health,scale up manufacturing,accuracy,measuring device,global market,feasibility,rapid,simple,user friendly,monitoring,allergen
RNA Polymerase III Rpc4/Rpc5 subcomplex and Selenocysteine tRNA transcription (Human Rpc5)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In higher eukaryotes, the RNA polymerase III (Pol III) participates in the transcription of small RNAs such as the tRNAs. RNA polymerase recruitment to their specific promoter relies on the activity of several transcription factors. Brf2 is a transcription factor that exclusively recruits RNA Pol III at the selenocysteine tRNA (tRNASec). Unpublished work from our group has unravelled an unanticipated central role of Brf2 in the oxidative stress response pathway, by acting as a cellular blockade during prolonged oxidative stress. We are interested in understanding the molecular determinants that govern RNA Pol III recruitment at tRNASec promoter and its interaction with Brf2-bound promoters. In general, RNA Pol III subunit’s size is conserved amongst the eukaryotic kingdom. However, an exception is the human Rpc5 subunit, whose C terminus has 450 residues that are not present in its yeast counterpart C37. Similarly to Brf2, the Rpc5 C-terminal extension is only present in higher metazoans, which suggests a phylogenetic link between these two proteins. The recruiting mechanism of RNA Pol III to Brf2-dependent promoters has not been described to date. Preliminary results in our lab provide evidences that indeed Rpc5 C terminus is responsible for the accurate recruitment of RNA Pol III at TBP/Brf2/DNA complex. Interestingly, structural homology predictions indicated that the human Rpc5 C-terminal extension is a eukaryotic homologue of the prokaryotic protein SelB, a factor that interacts with the tRNASec and with a specific region of mRNAs, the SECIS-element, during translation of SeCys containing proteins. This similarity suggests a regulatory role for Rpc5 C terminus in the interaction with the SECIS-element and/or the tRNASec. Our main objectives are to determine the structure of the Rpc5 C terminus in isolation and in complex with Brf2/TBP/DNA by X-ray crystallography and to characterise the role of Rpc5 C terminus in the context of tRNASec transcription.

Keywords: rna polymerase iii,gene transcription,brf2,selenocysteine trna,structural biology
Ocular Research By Integrated Training And Learning (ORBITAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Iceland,Spain,Spain,Ireland,Italy,Ireland,Italy,Finland,United States,United Kingdom,United Kingdom,Portugal,Canada
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 4066231.32
EU funding (EUR): 4066231.32
Participants: 23
Project status: SIGNED

Diseases of the posterior segment of the eye are increasing considerably, partly due to an ageing population (almost 20% of the population of Europe now over 65). Despite accounting for approximately 55% of ocular conditions, only 5% of ocular product sales target the posterior segment due to the technical difficulties in developing safe, effective and easy-to-use formulations. Age-related Macular Degeneration and Diabetic retinopathy are some of the main cause of blindness and severe impairment of vision in patients. These diseases represent a considerable burden on patients and healthcare systems throughout the world. ORBITAL has the primary objective of recruiting excellent early stage researchers (ESRs) and developing the next generation of research leaders and drivers. There is a clear unmet clinical need for efficient, safe, non-invasive and patient-friendly strategies for the treatment of prevalent diseases of the posterior segment of the eye. With a necessary collaborative network of European and global experts, from academic, clinical and industrial sectors, ESRs will be exposed to an integrated and complementary network of expertise in materials science, nanotechnology, animal modeling, enhanced in-vitro testing, analytical chemistry and drug discovery. ORBITAL will build an intersectoral consortium with extensive experience in generating innovative technologies and training new researchers. ESRs will be exposed to a broad scientific landscape of complementary disciplines. With the combined skills and knowledge of the consortium, ESRs will be provided with the network, skills and knowledge to develop their careers while the extensive mobility of researchers will lead to increased knowledge transfer and collaborative research

Keywords: drug delivery,ocular modeling,formulations,medical devices,posterior segment disease,in vivo models,ex vivo models,in vitro models,patient,oriented research,materials science
How much is a man worth. Slavery and market of individual identities in early modern Naples and Valencia (Men of Value)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This research aims to study the identity formation processes of slaves and captives in the Mediterranean between 16th and 17th centuries. It will do so by analysing the slaves markets of Naples and Valencia, two of the most important trading cities of the Spanish Empire. The project will combine different types of unexplored archival sources including the trials on slaves to be found within the Archivo del Reino of Valencia and a unique source represented by the book nr. 42 coming from Secretaría de Estado of the Archivo General de Simancas. The latter is as of now the most detailed source available on Mediterranean slavery, outlining the profiles of 657 slaves and captives aboard 26 privately-operated Neapolitan galleys in 1585. These sources will make it possible to focus in depth on the biography of slaves and the process of calculating their price. Through this analysis, my project aims to significantly contribute to two historiographical mainstreams: Mediterranean slavery and formation of personal identities in ancient regime. The underlying idea is that at the core of both these phenomena was an estimation process of 'how much is a man (and woman) worth' including social, psychological and economic aspects. To this end, I propose to read together the two topics (formation of personal identities and slavery) by doing a microanalytical study of men forced to labour. The main references for this analysis will be the micro-sociology of prices elaborated by Bourdieu and Boltanski and recent studies on social estimation processes in history, focusing on biographies as well as using case-studies oriented methodology. The fellowship will include a significant secondment to EHESS in Paris, and will result in the third monograph of the researcher on negotiated identities in modern Mediterranean.

Keywords: mediterranean slavery,slaves market,slaves identities,slaves value,captives value,the economy of,ransoming,slaves biographies,captives biographies
FAERSK – Innovative fish processing and logistics solution (FAERSK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-07-01
End date: 2018-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

At Arctic IP, we want to bring nutritious, additive-free fish to the mass market. Today, fish that you buy in the supermarket is loaded with phosphates and antioxidants to preserve its color and reduce spoilage during its 10-day journey from catch, to a secondary processing plant, to consumer. With our patented FAERSK solution, we are turning turns today’s fish processing and distribution chain on its head. Using 2 patented innovations, the fish is cut into fillets and wrapped in the final packaging for transport and sale, all at the source fishery. And thanks to our vacuum-assisted pressure technology, the fish is dry cured naturally during transport. No need for additives, ice or single-use EPS boxes. FAERSK enables catch-to-consumer within 5 days, with the highest freshness index in the market. Sustainability is baked into our revolutionary business model – by shipping fillets only, the payload (net sellable product) for the average long-haul transport van increases by 200% creating massive fuel savings. FAERSK salmon fillets have won the acclaim of leading European supermarket chains and TV chefs. In Europe alone, we initially target the €12Bn retail salmon market. Funding and support from this phase 1 feasibility project will allow us to: 1) perform selected testing with first distributors to test product-market fit; 2) strengthen our Intellectual Property portfolio, comply with EU and USA regulations and obtain industry certifications and; 3) assess the feasibility of our business model and develop a market-winning business plan including a financial plan. A favorable feasibility study and detailed business plan will allow us to move forward and develop a Beta product that we plan to validate in a large-scale pilot with real customers, as part of our envisioned phase 2 project. with a planned commercial launch in Q3 2020, we aim to bring in €360M in annual revenues and grow our team to 180+ employees.

Keywords: industrial processing,fish processing,fast processing,organic preservation,zero plastic waste,inosine monophosphate imp freshness,efficient transport,low carbon footprint
Innovative products by using tanned sturgeon skin (STURSKIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

STURSKIN was born as a desire to develop innovative techniques with less environmental impact for the enhancement of a new unique skin. Newport values a by-product, skin of sturgeon, otherwise disposed of, making it a high value-added product: waste is transformed into a resource with high added value. The innovative tanning process, which has already made it possible to obtain finished skins on a pilot scale, combines particular techniques with use of natural tanning products, in order to obtain the tanning of a very delicate skin. The control of the internal conditions of the tanning drum is a fundamental requirement for the success of the tanning, and after years of research the "right recipe" has been identified. Newport has succeeded in obtaining a unique, inimitable artificial leather, which as such is destined to find a place in the very high-quality fashion. Uniqueness is the market driver in high-end fashion, and Newport intends to address this segment. Sturgeon skin should be used for the production of unique pieces, with a very high added value. The bone plates give the skin a unique design and appearance, which has already proved highly attractive for different stylists. The main use of this skin will be in the production of objects (for example key rings), wallets and bags. Newport intention was to look for raw skins that did not derive from the selective breeding of species destined for the production of leather as primary purpose, but which are by-products of other industries that normally disposed them of. After years of research, the focus has been on skin of sturgeons, which are bred for the production of the precious caviar. Once the eggs have been removed, the remains of the fish are eliminated with a cost for caviar companies. Newport has considered the skin of the sturgeon to be very interesting, which has very specific bony plates on the back, with absolutely unique and inimitable designs.

Keywords: tanning process,waste reuse,enviroment protection,innovative products,right recipe,high quality,fashion,unique and inimitable designs,new market
Continuous self-assembly using enzyme mediated supramolecular switching (ASSEMZYME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-24
End date: 2017-03-23
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Supramolecular chemistry has resulted in truly sophisticated architectures, many of which are able to exert specific functions, as well as to change and adapt in response to external stimuli. So far, however, artificial structures with a similar functional complexity as living self-assembled systems are lacking. This is because nearly all current supramolecular systems are in thermodynamic equilibrium or kinetically trapped states. Living systems, on the other hand, operate far from equilibrium in so-called dissipative steady states, and continuously consume energy to keep their structure and function. Mimicking nature, here we propose to prepare dissipative self-assembled steady states of synthetic discotic molecules, controlled by competitive enzymatic pathways (phosphorylation / dephosphorylation), in which the supramolecular assemblies are kept far from equilibrium by a continuous perturbation i.e. the influx of a chemical fuel. We expect to get fundamentally new insights into non-equilibrium self-assembly, opening the door to truly adaptive, self-healing, life-like complex artificial systems. The candidate will be trained in a promising new research area in one of the hotspots for supramolecular chemistry in Europe, which would be a great stepping stone for his future independent research career.

Keywords: self assembly,non equilibrium,dissipative steady states,enzyme switching,stimuli responsive aggregates
Discovery strategies for Dark Matter and new phenomena in hadronic signatures with the ATLAS detector at the Large Hadron Collider (DARKJETS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2021-07-31
Duration (months): 66.0
Total project cost (EUR): 1268076.0
EU funding (EUR): 1268076.0
Participants: 1
Project status: CLOSED

The Standard Model of Particle Physics describes the fundamental components of ordinary matter and their interactions. Despite its success in predicting many experimental results, the Standard Model fails to account for a number of interesting phenomena. One phenomenon of particular interest is the large excess of unobservable (Dark) matter in the Universe. This excess cannot be explained by Standard Model particles. A compelling hypothesis is that Dark Matter is comprised of particles that can be produced in the proton-proton collisions from the Large Hadron Collider (LHC) at CERN. Within this project, I will build a team of researchers at Lund University dedicated to searches for signals of the presence of Dark Matter particles. The discovery strategies employed seek the decays of particles that either mediate the interactions between Dark and Standard Model particles or are produced in association with Dark Matter. These new particles manifest in detectors as two, three, or four collimated jets of particles (hadronic jets). The LHC will resume delivery of proton-proton collisions to the ATLAS detector in 2015. Searches for new, rare, low mass particles such as Dark Matter mediators have so far been hindered by constraints on the rates of data that can be stored. These constraints will be overcome through the implementation of a novel real-time data analysis technique and a new search signature, both introduced to ATLAS by this project. The coincidence of this project with the upcoming LHC runs and the software and hardware improvements within the ATLAS detector is a unique opportunity to increase the sensitivity to hadronically decaying new particles by a large margin with respect to any previous searches. The results of these searches will be interpreted within a comprehensive and coherent set of theoretical benchmarks, highlighting the strengths of collider experiments in the global quest for Dark Matter.

Keywords: new phenomena beyond the standard model,hadronic jets,atlas,large hadron collider,quantum chromodynamics
Electron quantum optics in Graphene (COHEGRAPH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-07-31
Duration (months): 75.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Quantum computing is based on the manipulation of quantum bits (qubits) to enhance the efficiency of information processing. In solid-state systems, two approaches have been explored: • static qubits, coupled to quantum buses used for manipulation and information transmission, • flying qubits which are mobile qubits propagating in quantum circuits for further manipulation. Flying qubits research led to the recent emergence of the field of electron quantum optics, where electrons play the role of photons in quantum optic like experiments. This has recently led to the development of electronic quantum interferometry as well as single electron sources. As of yet, such experiments have only been successfully implemented in semi-conductor heterostructures cooled at extremely low temperatures. Realizing electron quantum optics experiments in graphene, an inexpensive material showing a high degree of quantum coherence even at moderately low temperatures, would be a strong evidence that quantum computing in graphene is within reach. One of the most elementary building blocks necessary to perform electron quantum optics experiments is the electron beam splitter, which is the electronic analog of a beam splitter for light. However, the usual scheme for electron beam splitters in semi-conductor heterostructures is not available in graphene because of its gapless band structure. I propose a breakthrough in this direction where pn junction plays the role of electron beam splitter. This will lead to the following achievements considered as important steps towards quantum computing: • electronic Mach Zehnder interferometry used to study the quantum coherence properties of graphene, • two electrons Aharonov Bohm interferometry used to generate entangled states as an elementary quantum gate, • the implementation of on-demand electronic sources in the GHz range for graphene flying qubits.