Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Analysis of Tenascin C function in breast cancer metastasis to bone (BONEMETTNC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-06-01
End date: 2017-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Metastasis is the spread and outgrowth of cancer cells in organs distant from the site of origin. In breast cancer, the bone is the most common site of metastasis and metastatic outgrowth in the bone causes hundreds of thousands of deaths world-wide every year. In recent years it has become evident that stem cell characteristics play an important role in cancer progression and metastasis. These characteristics are not only intrinsically determined but also maintained and even induced by the microenvironment — the metastatic niche — suggesting a very complex interaction between cancer stem cells and their niches. We have identified an essential niche component for metastasis of breast cancer. This component is the extracellular matrix (ECM) protein tenascin C (TNC). We demonstrated, that in the context of lung metastasis, TNC engages stem cell signaling pathways to promote fitness of metastasis initiating cells. Moreover, we demonstrated that TNC is also crucial for breast cancer metastasis to bone. However, the cellular functions and signaling mediated by TNC and the surface receptors TNC engages in disseminated breast cancer cells growing into bone metastasis is unknown. We aim to address this in an integrative way using 3D culture systems of primary cancer cells, RNA interference, transcriptomic and proteomic screens, genetic- and xenograft -mouse models of cancer progression and metastasis. Moreover, we aim to use mouse models to address if inhibiting TNC, TNC-receptors or downstream signaling can sensitize bone metastasis to therapeutic intervention. Increasing evidence suggests that proteins of the extracellular matrix (ECM) support the fitness of disseminated cancer cells at distant sites, facilitating metastatic outgrowth. Targeting these components may provide the means to impair the competence of disseminated cancer cells and prevent metastatic relapse.

Keywords: breast cancer,bone metastasis,extracellular matrix,stem cell characteristics,cellular signaling,drug target,niche,mouse models
Universality in Topological Dynamics (UNIVERSALITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aim of the project is to investigate the phenomenon of universality in Topological Dynamics. Universality is a classical and fundamental subject in Dimension Theory. The introduction of universality to the context of dynamics is more recent but has already proven itself to be fruitful. The far reaching Lindenstrauss -Tsukamoto Conjecture is the claim that mean dimension and periodic dimension are the only obstructions for embedding in the dynamical context. Mean dimension is an invariant introduced by Gromov a decade ago and has already found applications in diverse fields such as Symbolic Dynamics, Cellular Automata, Holomorphic Functions , Mathematical Physics as well as in Topological Dynamics, notably in Boyle-Downarowicz Symbolic Extension Entropy Theorem and its Z^k -generalization by the Researcher. The project also tackles related conjectures involving the small boundary property, the topological Rokhlin property (a topological analogue of the celebrated Rokhlin Lemma from measured dynamics) and the dynamical version of the classical Sum Theorem from Dimension Theory. The Researcher, a PhD from the Hebrew University who is currently a postdoc at the University of Cambridge seeks to integrate at the Institute of Mathematics of the Polish Academy of Sciences (IMPAN) which has a long and distinguished history in Topology and its applications. The Researcher worked at IMPAN for 9 months, during which the fit between the Researcher and the Institute was evident. It is certain that this Career Integration Grant will enable the first step of a life long academic career at the Host Institute. Moreover the project by its quality, originality and novelty will contribute to the EU excellence, as well as to the Host Institute through transfer of knowledge through courses and research students and to the mathematical community and the public at large through cooperation and dissemination of new and old results for both specialists and non specialists.

Keywords: universality,embeddings,mean dimension,markers,topological rokhlin property,small boundary property
Glycosylation Catalysts (GLYCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2016-06-30
Duration (months): 39.0
Total project cost (EUR): 81250.0
EU funding (EUR): 81250.0
Participants: 1
Project status: CLOSED

Catalysts for stereoselective glycosylations will be developed. The focus being on designing organocatalysts for catalyst-controlled glycosylations. Carbohydrates, the most abundant biomolecules on Earth, are intimately involved in many crucial biological processes (signal transduction, cell recognition) and in diseases (AIDS, cancer). They are useful for the investigation of diseases, and have great potential as vaccines and therapeutics. The biology depends on the specific identity (including stereochemistry) of the carbohydrates (usually oligosaccharides – several monosaccharides joined together). A significant bottleneck in making scientific progress in the strategically important field of glycoscience is the effort and expense required to synthesise pure oligosaccharides and glycoconjugates as single stereochemical isomers. A major synthetic difficulty with oligosaccharides (vs. oligonucleotides or oligopeptides) is the diversity that can exist: a rough calculation suggests that there are ~256 DNA tetranucleotides, ~160,000 tetrapeptides and >4x10^7 linear tetrasaccharides. Added permutations arise from the variety of monosaccharide stereoisomers and the different connectivities possible at each linkage. Many oligosacchardies are not linear but branched - adding further permutations. Given the impact of the ability to easily synthesise oligopeptides and oligonucleotides have had on modern biology, it is difficult to predict the impact of technology that would allow oligosaccharides to be synthesised with similar ease, other than that it would be highly significant. The proposal seeks to work towards this goal in a way that is complementary to approaches currently being used. Over the past 30 years stereoselective catalysis has transformed the availability of chiral molecules in enantiopure form. However, it has yet to make a similar impact on carbohydrate chemistry. GlyCat will be at the forefront of efforts to change the status quo in saccharide synthesis.

Keywords: catalysis,asymmetric,stereoselective synthesis,organocatalysis,carboydrate,glycosylation
A quantum computer based on electron spins in carbon nanomaterials (NANOTUBEQUBIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

I will create a two-qubit universal quantum computer based on electron spins a carbon nanotube. Nanotubes are outstanding host material for spin qubits, because they allow hyperfine decoherence to be completely eliminated. Very recently, I demonstrated the first single qubit in a nanotube, using electric fields combined with a bend in the nanotube to coherently control an electron's spin. This project will realize the additional elements for a computer: high-fidelity qubit readout, a two-qubit gate, and long-lived quantum memory. The objectives are threefold. First, I will perform single-shot readout by incorporating radio-frequency single-electron-transistors into a qubit device. Using established spin-to-charge conversion techniques, this will allow independent readout of multiple qubits. Second, I will use the exchange coupling between adjacent nanotube quantum dots to implement a universal two-qubit gate. Finally, I will create a long-lived quantum memory based on spin-active endohedral fullerene molecules chemically attached to the nanotube. These molecules have already shown outstanding quantum coherence properties in ensembles, which I will exploit for devices for the first time. The end goal is a device capable of implementing arbitrary two-bit quantum algorithms, opening the way to a scalable quantum computer based on carbon electronics.

Keywords: p212 nanophysics
Mapping the Complexity of Counting (MCC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: United Kingdom
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-03-01
End date: 2019-08-31
Duration (months): 66.0
Total project cost (EUR): 2499093.0
EU funding (EUR): 2499093.0
Participants: 1
Project status: CLOSED

Just as advances in engineering rely on a deep foundational knowledge of physics, so too advances in algorithms and programming rely on a deep knowledge of the intrinsic nature of computation. Significant progress has been made, particularly in the field of computational complexity, which aims to discover which computational problems are feasible, which are inherently infeasible, and why. However, huge theoretical challenges remain: many problem classes are poorly understood, including those containing problems arising in practical applications. The MCC project will enable significant computational advances in a host of application areas through the development of a comprehensive theory of counting problems. These problems, which involve the computation of weighted sums, are common and important, arising in practical applications from diverse fields including statistics, statistical physics, information theory, coding, and machine learning. Thus, it is of fundamental importance to understand their complexity. We propose a coherent and systematic study of the complexity of counting problems. A sequence of exciting recent developments, pioneered by the PI and others, makes it plausible that we now have the tools needed to make substantial progress. The overall objectives of MCC are (1) Map out the landscape of computational counting problems (exact and approximate), determining which problems are tractable, and which are intractable (quantifying the extent of tractability), and (2) Develop complexity characterisations elucidating the features that make counting problems tractable or intractable, not only discovering which problems are tractable, but also discovering a characterisation telling us why. The project encompasses a large range of wide-open problems. However, the strength of the PI, the scale of the project, the timeliness of the project (given recent results), and the novel methods proposed make it certain that the research will produce breakthroughs.

Keywords: theory of computation,computational complexity,counting,approximation,constraint satisfaction problems,partition functions
Next-generation 3D Meshing (VORPALINE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-06-30
Duration (months): 12.0
Total project cost (EUR): 149800.0
EU funding (EUR): 149800.0
Participants: 1
Project status: CLOSED

The VORPALINE ``Proof of Concept'' project concerns the pre-commercialization of a 3D mesh generation software with innovative functionalities resulting from research. Mesh generation plays a central role in numerical simulation, used to predict the behavior of engineering and physical systems under various conditions. Numerical simulation is a key to the competitiveness of many companies. For instance: (1) in aircraft industry, when optimizing the design of the wings, months of costly experiments in wind tunnels can be replaced with a few hours of computer simulation; (2) in oil and gas industry, numerical fluid simulation makes it possible to compute the placement of wells that optimizes oil production. The efficiency and accuracy of numerical simulation depends on the quality of the underlying computerized representation, i.e. a 3D mesh. By ``quality'', engineers mean some geometric characterizations of the mesh elements. VORPALINE takes a new approach to 3D mesh generation, based on the optimal mesh generation algorithm stemming from ``starting-grant'' project GOODSHAPE. Our algorithm generates a 3D mesh of high-quality, by globally optimizing the elements of the mesh with respect to user-defined geometric criteria that existing softwares cannot take into account. The goal of the VORPALINE project is to turn our research prototype into a 3D mesh generation software ready to be used and evaluated by potential customers. This includes our preliminary contacts in oil&gas and in Computer Aided Engineering with whom we started technology testing. The longer-term goal is to market the software through the European leading company of this field, that has started to evaluate our technology. We think that VORPALINE has the potential to push the limits of 3D mesh generation in terms of quality, flexibility and efficiency.

Keywords: 205693
Smart nanoparticle system for lung cancer application (NANOSMART)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-04-01
End date: 2014-03-31
Duration (months): 12.0
Total project cost (EUR): 159000.0
EU funding (EUR): 143400.0
Participants: 1
Project status: CLOSED

As a result of the research undertook in the MYCAP ERC project, Dr Martín del Valle’s team have developed a new smart nanoparticle for delivering cisplatin, which is the current lung cancer standard of care (SoC). In order to accelerate its market entry, the present “Proof of Concept” (PoC) project, named NANOSPART, will conduct in vitro validation of cisplatin nanoparticles through cell lines culture assays, as well as the technological optimization of the drug delivering system and the upper spray-based technology arisen from “MYCAP” ERC funded. The work undertaken so far requires further investment in applied research, in order to turn the outputs shown above into a commercial proposition. The NANOSMART project will make an important contribution towards the future pre-clinical and clinical phases, and new key industrial applications. Dr. Martín del Valle´s team have developed a new drug delivery system (DDS) for lung cancer treatment based on polymer nanoparticles, as a result of MYCAP project. Dr Martín del Valle now aims to progress this idea to PoC through the NANOSMART project, which has mainly three goals: defining the right chemical properties of these nanoparticles; determining the optimal dose of cisplatin-conjugates in relation to toxicity and efficacy parameters; In terms of expected outcomes, the project will contribute to meet critical market needs in lung cancer treatment. Globally, lung cancer is one of the most common types of cancer, with an estimated 1.2 million new cases being diagnosed every year. Despite the emergence of new treatments, 85% of lung cancer patients don’t survive, which is mainly due to metastatic disease . Because of the overall poor prognosis, new treatment strategies for lung cancer patients are urgently needed. Dr. Eva Martín del Valle and her team from University of Salamanca, are willing to address this issue with a new approach that utilises novel nanopartictechnology to deliver the current SoC (cisplatin).

Keywords: 258984
Commercial Applications for RF Arrays of Traps (CARAT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Austria
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-12-01
End date: 2014-11-30
Duration (months): 12.0
Total project cost (EUR): 157600.0
EU funding (EUR): 144860.0
Participants: 1
Project status: CLOSED

The ERC-funded project CRYTERION has a goal of scaling up simulations and computations with trapped ions. One possible route for this is the use of a 2D array of ion traps. During the development of these 2D arrays, a novel method of being able to address the interactions was conceived, allowing addressing of individual ions and nearest-neighbour interactions between ions in the array. A patent has been granted on the design and the ERC-POC grant is being applied for so as to develop an implementation with the goal of licensing the patent. Technical tests of this idea with calcium ions have been performed on a mesoscale array of ion traps. Basic ideas for creating micro-scale traps are under investigation. We propose that this micro-array concept be developed, to the point where traps can be provided to potential customers for evaluation. Besides the technical realization of the POC it is necessary to analyse the market, i.e. identify customers as well as producers and develop a strategy for how to target these two groups successfully

Keywords: 227959
“MycoBiotics” as a new technology platform for the treatment of human respiratory and genital tract diseases (MICO PLUNG)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-12-31
Duration (months): 18.0
Total project cost (EUR): 165429.91
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The use of Mycoplasma pneumoniae or its closest relative M. genitalium engineered for the controlled delivery of therapeutic peptides or proteins in situ, i.e. where they currently reside, could open new possibilities for the treatment of lung and genital tract diseases. Taking advantage of the parasite nature of M. pneumoniae to lung tissue, we plan to use genetically engineered forms of this bacterium for the local, and eventually conditional delivery of therapeutic proteins in the context of distinct and many times highly invalidating respiratory disorders, as a proof-of-concept of a new technology platform. Results of the work done at the CRG on the two projects above shall be validated in vitro and in vivo and, if successful, constitute the basis for a licensing agreement, or eventually a spin-off company created to bring the engineered bacteria or modifications thereof into the clinic. Interestingly, additional applications could be proposed at some point to diseases of the genital tract using engineered M. genitalium as a living vector.

Keywords: 232913
Contemporary Indigenous Performance: Resources for Cross-cultural Dialogues (CIPRID)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-06-30
Duration (months): 12.0
Total project cost (EUR): 164840.75
EU funding (EUR): 149934.0
Participants: 1
Project status: CLOSED

This project develops and tests two related innovations – an interactive online exhibition and an arts consultancy service – as complementary parts of a package of cultural resources. The package is designed to make the research produced by the Indigeneity in the Contemporary World (ICW) project team accessible to the public, and, also, to stimulate new creative and educational uses of the project’s findings, in collaboration with indigenous artists, intellectuals and communities. The proposed innovations will maximize the reach and social impact of the ICW project by tapping its vast audiovisual records and international networks to foster creative dialogues among indigenous performance makers and cultural-sector workers and audiences, in Europe and beyond. The ICW team possesses a wealth of specialist knowledge about ways in which indigenous performance illuminates social and political debates on a transnational scale. Using this knowledge, the team hopes to build bridges between cultures and art forms. At a broader level, the online exhibition and consultancy service are conceived as building blocks for a new, flexible, open-access archive of interlinked multi-modal resources that will encourage users to engage with contemporary indigenous performance in dynamic ways. Performances are live and embodied, while records of cultural events exist in objects and recordings that can seem staid and unapproachable. The aim of this project is to model a unique, accessible and ethical resource platform that brings the intangible processes of performance making into dialogue with tangible records of specific events. Our objective is to change the ways in which Europe conceives of its colonial pasts and its multicultural futures.

Keywords: 230569