Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Solitons and frequency combs in micro-resonators (SOLIRING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: South Africa,Sweden,Russian Federation,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-02-28
Duration (months): 38.0
Total project cost (EUR): 157500.0
EU funding (EUR): 139500.0
Participants: 6
Project status: CLOSED

The proposed research network will establish and support multi-lateral transfer of knowledge among leading research groups in the UK, Sweden, South Africa and Russia. The programme will allow to combine and share valuable cross-disciplinary expertise of the participating groups in the fields of nonlinear fiber optics, optical microresonators, nano-photonics, optical microcavities and nonlinear dynamics, to advance studies of frequency comb generation, parametric amplification, frequency conversion processes, and slow light dynamics in microring resonators and surface nano-scale axial photonics resonant structures. One of the primary goals of this project is to elucidate the role of soliton dynamics in the frequency comb generation and parametric amplification processes in micro-ring resonators and related nano-photonic setups. The theoretical analyses of bright and dark, scalar and vector solitons, their instabilities and bifurcations, the interaction of solitons with linear waves and between themselves; of the soliton dynamics in systems with the second-order and Raman nonlinearities; of the effects of discreteness and domain periodicity -- will be carried out. These fundamental studies will be further utilized to propose new methods of the manipulation and stabilization of frequency combs, the generation of secondary combs as well as for the investigation of comb locking mechanism and development of theory of microring fiber lasers. In the course of this project, informal research links already existing between some of the partners will be taken to a new level and shape a functional research network. The complementary expertise of partners in this network will be crucial to tackle the cross-disciplinary scientific problems associated with studies of frequency comb generation and parametric amplification processes in micro-resonators. Formation of this network will be of considerable benefit to the research within the individual groups and at the European level.

Keywords: micro resonators,frequency combs,solitons,nonlinear optics
Cross-Layer Design of Securing Positioning (CSP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1952274.0
EU funding (EUR): 1952274.0
Participants: 1
Project status: CLOSED

With the development of new location-based services and the expected deployment of cyber-physical systems (e.g., autonomous cars and drones) the reliance on location and time information in critical applications will only increase. Today's positioning systems are vulnerable to location spoofing by which devices can cheat on their own positions or can manipulate the measured positions of other devices. This problem cannot be fixed by a simple upgrade - existing positioning systems rely on legacy distance measurement techniques and protocols that were designed without security considerations or with security as an after-thought. We therefore need a new approach to the design of positioning systems that takes security requirements into account from the very start, and also accounts for the way that positioning systems are built and used. This is a cross-layer endeavor. In this project we will address the following fundamental questions: (1) Physical Layer. How can we design the right distance measurement (i.e., distance bounding) techniques that provide resilience to physical-layer and logical-layer attacks but retain the performance (range, accuracy and speed of execution) of equivalent non-secure systems? We will extend the existing knowledge in terms of the attacker models as well as achievable limits of security and performance of distance measurement techniques under realistic attacker models. (2) Link Layer. What are the right Medium Access Control (MAC) protocols for secure positioning, what are their performance and scalability limits? (3) Systems. How can distance bounding be integrated in mobile platforms, especially with trusted execution environments. How can this integration strengthen the security of distance bounding and support its use in a wide range of applications?

Keywords: secure positioning,distance bounding
IN-OVO AUTOMATION FOR CANCER DRUG DISCOVERY (OVOMATIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: France
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently, the in vivo step in the drug discovery process is always performed using the mouse model. This step is expensive and time-consuming, with an average cost of 40k€ per molecule tested and an average duration of 6-9 months. It represents a huge obstacle for the pharmaceutical industry, leading to fewer new drugs brought to market each year, and insufficient treatments for severe pathologies such as cancer or orphan diseases. INOVOTION can play a major role in solving this huge societal issue: we have the technology to revolutionize drug discovery by automating in vivo drug evaluation for efficacy and toxicity. INOVOTION is a spin-off of the University of Grenoble, founded in 2014 by Prof. Viallet. Our researchers have been working since 2009 on a new proprietary technology to perform “in ovo” assays that precede mouse testing, using chick embryos. Our tests allow researchers to eliminate low-value molecules at an early stage in the process, and to dedicate mouse testing for high-potential molecules only. Furthermore, our technology is reliable, reproducible, highly sensitive, fast and automatable. The successful 150 studies we performed for big pharma, small biotechs and academics (in the USA, France, UK, Japan, South Africa, Czech Republic and the United Arab Emirates) have confirmed the market demand for our technology. The worldwide market for in vivo testing is about 30 billion euros per year, mainly for cancer research, and INOVOTION has the technology to meet the market's needs. For each 1% in market share we cover, we could save the pharmaceutical industry up to 240 M€. The OVOMATIC project aims to initiate an automated “in ovo” process including developing a robot tool head prototype, and finalise the commercial and financial strategies of our approach. The long-range impact of the OVOMATIC project is to introduce this new tool into the pharmaceutical landscape, greatly increasing the productivity of our clients' anti-cancer drug discovery efforts.

Keywords: drug discovery,cancer,robot,automation,pharma,in vivo,biopharma,assay
BOOSTing the industrial application of green carbides by thermal spraying in protective coatings (BoosT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 1291750.0
EU funding (EUR): 904225.0
Participants: 2
Project status: CLOSED

The BoosT project aims to introduce advanced materials as alternatives for the efficient deposition of wear and corrosion resistant coatings by Thermal Spraying in highly demanding applications. The project goal is to substitute the currently critical materials used in Thermal Spraying coating – Co, Ni and WC, CrC- by green elements as Fe, Ti based metals and TiC, SiC carbides. BoosT materials and coatings will be depolyed in several industrial applications with advanatages in terms of cost savings, securing of raw material sources and removing of toxic materials. This will be possible by using the BoosT nanostructured powder produced by Mechanomade® technology of MBN for the deposition of coatings with superior characteristics compared to the current thermal spraying materials (WCCo and NiCr3C2). In the framework of the scope and the expected impact of the call the following objectives have been identified •Optimize the production route of innovative nanostructured cermets powders for thermal spraying with improved wear resistance and corrosion inhibition •Optimize the thermal spraying process by HVOF and extend spraying procedures to other methods as CGS and HVAF •Increase the robustness and repeatability of the industrial processes of powder production plant able to deliver up to 50tons/year of nanostructured powder •Qualification of the pilot production route for the application of the coating on components for pulp and paper , food processing, mechanical industries with massive cost saving up to 60% •Commercial proposition of coatings and materials to early adopters industrial customer The BoosT exploitation and business targets are to: - replace WCCoCr products occupying the related market segments - acquire by 2022 20 early costumers to sale about 30-40 tons of BoosT series powders - acquire by 2025 at least 75-100 costumers globally.

Keywords: thermal spraying,wear resistant coatings,green carbides,nanostructured powder,food processing industry,pulp and paper industry
Smart Theranostic Agents for the Tumour Microenvironment (FLUORODRUGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

FLUORODRUGS is a highly interdisciplinary project encompassing the design, synthesis and biological validation of novel smart chemical agents for highly sensitive diagnosis and specific treatment of cancer. I will prepare novel drug-fluorophores conjugates by combining macrophage-specific fluorophores with cytotoxic drugs using smart cleavable linkers. The activation of these smart agents in the tumour microenvironment will allow to not only to visualise in real-time but also to selectively ablate tumour-associated macrophages, which are essential for cancer progression. Further derivatization of the agents with specific ligands (i.e. chemokine CCL2) will yield probes for specific subpopulations of macrophages (i.e. CCR2+ macrophages) that are critical in tumour metastasis. This strategy will minimise two of the major limitations of conventional cancer therapies: 1) drug resistance from cancer cells, and 2) toxic side effects derived from low cell specificity. Notably, the visualisation of immune cells in the tumour microenvironment will allow to monitor cancer progression in real-time and to run profiling studies to discover new biomarkers for cancer therapy. Initial in vitro studies to confirm the activity and selectivity of FLUORODRUGS will be performed in bone marrow-derived macrophages. Further, relevant mouse cancer models will be used to validate the theranostic agents in vivo. FLUORODRUGS will involve multidisciplinary training in biology, spectroscopy, pharmacology and imaging, and will render a unique generation of smart chemical tools to enhance diagnosis and treatment of cancer. This project will open a whole range of opportunities for my future career development in cancer biology and medicinal chemistry.

Keywords: imaging,fluorescent probes,cancer therapy,theranostics
Intelligent control system based on smart textiles to reduce pressure injury risk by real time measure of tissue viability, and intelligent trigger of prevention strategies adapted to user and context (LiveRest)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 2016546.25
EU funding (EUR): 1411582.38
Participants: 1
Project status: CLOSED

85% of Spinal Cord Injury (SCI) patients will develop a Pressure Injury (PI), and 8% of them will die due to associated complications. PI treatment costs €20 billion per year to the European Public Health System (EPHS), uses a lot of resources (e.g. caregivers and hospital beds) and causes injuries to the caregivers that perform repositioning of the patients, resulting in compensation costs and extra human resource reduction. PI are preventable, however 38% of PI appear using current commercial prevention devices because PI risk assessment is only based on pressure instead of Tissue Viability (TV) which also takes into account user status and context. The aim of this project is to demonstrate in operational environment, produce and commercialise in the Assistive Technology market LiveRest system, a disruptive ICT solution that is able to avoid the development of PI, being the only device on the market that clinically demonstrates PI prevention. LiveRest will be embedded on a personalised wheelchair, and its novelties are: a) to measure PI risk in real time based on TV with impedance, pressure, temperature and humidity textile sensors; b) to decide the best combination of PI prevention strategies based on risk, user and context; and c) to perform the selected strategy based on combined actuation systems. LiveRest is aligned with key EU global challenges: disability, independent living, job inclusion, reduction of social and health care costs, and increase of labour. Target customers are SCI patients and hospitals. Benefits for the patients are increased sitting time and enhanced health, social inclusion, independent living and ageing well. EPHS savings will result in more than €40 million per year, plus avoid loss of medical resources. During Phase 2, we will achieve the free marketability of LiveRest, demonstrate the system in operational environment and elaborate an investor-ready business plan, including commercialisation and mass-production strategies.

Keywords: intelligent control,decision making algorithms,tissue viability,smart textile sensors,spinal cord injury,pressure injury,prevention,electrical wheelchair,assistive technology,ulcer
How antibodies and complement orchestrate protective immune responses against bacteria (ACCENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Due to antibiotic resistance, there is now great interest in the development of antibody-based therapies against bacterial infections, for instance via antibodies that boost the host immune system. In order to kill bacteria, antibodies should trigger activation of the complement cascade, which forms bactericidal Membrane Attack Complex (MAC) pores and strongly enhances phagocytosis. Although the power of complement could be exploited for antibody therapies, such developments are hampered by our limited insights into the mechanisms underlying antibody-dependent complement activation on bacteria. My team has developed unique assays to study complement activation on bacteria. In this proposal, we will combine our function-driven approaches with novel B cell sequencing methods to identify anti-bacterial antibodies with strong complement-activating potential. We will develop novel approaches to identify the variable (VH:VL) sequences of human antibodies that recognize whole bacterial cells. After FACS sorting of memory B cells or yeast Fab display, we will use multi-well functional assays to select monoclonal antibodies driving potent complement activation and subsequent killing of E. coli (via neutrophils or MAC). Thanks to our unique tools and unprecedented insights, we are in an unique position to decipher basic mechanisms by which antibodies induce bacterial killing via neutrophils or MAC. We will combine live-cell imaging and structural approaches to determine how bactericidal antibodies assemble lethal MAC pores in the bacterial cell envelope. Finally, we will explore the design of potent antibody combinations and study the mechanisms by which antibodies steer different effector functions, both in the context of clinical and non-pathogenic E. coli strains. Altogether, this grant will lead to fundamental knowledge about the functioning of the immune system and provide a biological basis for the development of antibody-based therapies against bacteria.

Keywords: antibodies,complement,phagocytosis,membrane attack complex,gram negative bacteria
Sub-Universal Quantum Circuits in Continuous Variables (CV SUBUNIQC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Three decades ago, it was proposed that quantum computers (i.e. quantum systems where information can be encoded, processed and read out) could outperform classical devices for information processing. For instance, they may allow the factoring of integer numbers in a time which scales polynomially with the size of the input, while known classical algorithms require an exponential time. However, in practice, it has not yet been possible to build a quantum computer large enough to beat classical machines. This has raised the question as to whether this difficulty is only technical, and will be overcome one day, or due to fundamental reasons. In trying to answer this question, physicists and computer scientists have developed "sub-universal" quantum computing models, which aim at solving very specific problems, simpler than factoring, but still displaying a quantum advantage. Among those is the so-called boson sampling protocol, which enables to compute the permanent of a unitary matrix. In other words, scientists now seek for the observation of a minimal supremacy of quantum computers over classical ones. Inspired by recent experimental achievements (Paris, Japan, Virginia), in this project I will study at the theoretical level new models of sub-universal quantum computers, based on original photonic architectures. Indeed, these models have been only poorly studied, so far, in the promising context of the "Continuous Variable" (CV) encoding, which has recently allowed to reach the record-size for quantum computing resource states. This project articulates through two main objectives: 1) The design of new sub-universal quantum circuits in CV, providing proof of their classical computational hardness 2) The study of viable experimental quantum optics platforms where these protocols may be efficiently implemented. Among those, I will design the first experimentally accessible protocol for CV boson sampling.

Keywords: quantum information,quantum optics,quantum computation
ADvanced Aeroacoustic Processing Techniques (ADAPT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,Netherlands
Call: New Acoustic Signal Processing Methods (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 363497.5
EU funding (EUR): 363497.5
Participants: 5
Project status: CLOSED

Airbus is currently conducting various experimental studies, dealing with installing microphones on the fuselage, on the wall of a wind tunnel test section or on specific microphone supports on the flow, in order to record the sounds emitted by each aircraft component (i.e. engine, wing etc.). In either case, microphone measurements are polluted by hydrodynamic noise, which hampers the correct assessment of acoustic signals emitted from aircraft components, thus leading to very low signal-to-noise ratio. A few methods exist today that can eliminate hydrodynamic noise from acoustic signals. However, the efficacy of these methods strongly depends on various parameters, such as signal-to-noise-ratio, number of microphones, number of incoherent sources etc. No systematic study has been performed so far to assess the parameter boundaries within which acceptable results are obtained (e.g. within 0.5 dB error for example). The ADAPT consortium will improve and optimize the ability of identifying sources emitted by aircraft components by using the most effective techniques out of the three proposed approaches in the call for proposal. These three approaches are: aeroacoustic source separation, de-noising techniques based on cyclostationarity and aeroacoustic sources localization. Through these three approaches, the ADAPT project aims at delivering to AIRBUS a tool dedicated to separating airframe and engine noise components (tonal, broadband cyclostationary components in particular) from hydrodynamic pressure noise and identifying these sources in space, satisfying various technical and economical requirements that will be discussed out with AIRBUS at the beginning of the project.

Keywords: aeroacouctics,source separation,de noising,source localization,bayesian approach,cyclostationarity,wind tunnel test,turbulent boundary layer,stochastic modelling,turbomachinery