Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromatin readout: Dissecting the protein-chromatin interaction code in living cells (ChromatinLEGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland,Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1850177.84
Participants: 2
Project status: SIGNED

Chromatin modifications are key regulators of genome function. They can be directly recognised by specialised protein reader domains, leading to coordinated recruitment of regulatory proteins to the genome in a dynamic, spatiotemporal manner. Despite many efforts to characterise chromatin-mediated protein recruitment, the underlying principles that determine specificity and how chromatin marks influence the proteome composition at genomic sites in living cells, remain unclear. Here I propose to uncover the underlying logic that mediates specificity between regulatory proteins and chromatin states by using a reductionistic approach that enables us to study these interactions in a controlled and comprehensive manner in living cells. Towards this we combine high-throughput stem cell engineering with functional genomics and computational methods to achieve the following aims: First, we aim to identify and characterise the genome-wide binding preferences of a comprehensive panel of chromatin reader domains (CRD) by using a novel strategy for comparative profiling of multiple protein-genome interactions in parallel. Second, we will systematically dissect the context-dependent determinants that mediate individual and combinatorial CRD binding to the genome. Finally, we will utilise the selectivity of CRDs to uncover the local proteome at defined chromatin states in ES and neuronal cells, revealing novel components involved in the regulation and organisation of the epigenome. The overarching goal of ChromatinLEGO is to elucidate in a systematic, quantitative and unified manner, how protein-genome interactions are guided by specific chromatin modifications. Through identifying the chromatin-dependent recruitment principles of regulatory factors, and by dissecting the underlying mechanisms that specify these interactions, this study will provide novel paradigms and important advances to our current understanding of chromatin function in vivo.

Keywords: chromatin marks,new methods,epigenetics,genomics,synthetic biology,chromatin engineering
Exoplanets Molecular Atmospheric Composition (ExoMAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-09
End date: 2022-11-08
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The search for and characterization of exoplanets are among the most active and rapidly advancing fields in modern astrophysics. To date, more than 4000 exoplanets have been detected, spanning wide ranges in physical, orbital and stellar parameters, and with a great variety of system architectures. Understanding the causes of exoplanet diversity and variety is a stated goal of the next-generation of ESA/NASA missions. In this context, I propose to develop the project "Exoplanets Molecular Atmospheric Composition" (ExoMAC), together with the Instituto de Astrofisica de Canarias (IAC) under the supervision of Dr. Enric Pallé. The project consists of the following Scientific Objectives: SO1: The complete and consistent (C&C) analyses of individual planets for measuring the absolute abundances of all the main carbon and oxygen-bearing molecules, metallicity down to less than 0.5 dex and precise C/O down to 0.1 dex in a handful of exoplanet atmospheres. The C&C analyses will provide the first empirical constraints on the possible formation and evolutionary paths of exoplanets; SO2: The development of a convolutional neural network (CNN) for the automated classification of newly-released TESS light-curves for the discovery and classification of new exoplanet populations. This CNN will lead to the discovery of more than 10000 transiting exoplanets, among which to select the prime targets for spectroscopic characterization with current and next-generation facilities. The C&C analyses propose a novel approach to leverage the information obtained with multiple instruments and observing techniques through a bayesian framework. We will adopt an updated version of the TauREx code to enable consistent retrievals, coupled with deep convolutional generative adversarial networks to speed up the likelihood sampling.

Keywords: exoplanet atmospheres,spectroscopy,consistent retrievals,bayesian statistics,neural networks
Furthering the Knowledge Base For Reducing the Environmental Footprint of Shale Gas Development (FracRisk) (FracRisk)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Germany,Spain,Israel,Sweden,France,United Kingdom
Call: Understanding, preventing and mitigating the potential environmental impacts and risks of shale gas exploration and exploitation (H2020-LCE-2014-1, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2939998.0
EU funding (EUR): 2939998.0
Participants: 12
Project status: CLOSED

FrakRisk further develops the knowledge base for understanding, preventing and mitigating the potential impact of the exploration and exploitation of shale gas reserves found throughout Europe. This will include international experience, state of the art process understanding, state of the art modelling techniques and the further development of fully accepted risk assessment tools for site screening, selection and management specifically for shale gas exploitation. FracRisk focuses on key knowledge gaps identified from the literature, research and industrial experience. Central to the project is the modelling of six exemplary scenarios selected to represent the highest risk environmental impact scenarios identified as generally of most concern. The modelling of the scenarios is directed by the aim to reduce the uncertainty and assess the risk of different events during shale gas exploration and exploitation. Using an iterative modelling and risk reduction approach, cost effective data density requirements to limit uncertainty will be evaluated. The modelled scenarios will be validated against existing data from several sites within the EU and in the USA. Effective monitoring procedures and applicable mitigation techniques will be determined and evaluated. Scientific recommendations will be formulated and legislative refinement suggested. Public concerns about the management of risk related to fracking operations will be addressed. A firm scientific basis and demonstrable data to validate recommendations will be provided. The technological readiness level from a number of multidisciplinary approaches and applications will be noticeably improved. FrakRisk will lead to a more focused, coherent and scientifically founded approach that can be useful to member states willing to enable and regulate the shale gas industry.

Keywords: shale gas
Robotic subsea exploration technologies (ROBUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Germany,Germany,Spain,Cyprus,France,United Kingdom
Call: New sustainable exploration technologies and geomodels (H2020-SC5-2015-one-stage, 2015)
Start date: 2015-12-01
End date: 2020-01-31
Duration (months): 50.0
Total project cost (EUR): 5986722.5
EU funding (EUR): 5986722.5
Participants: 11
Project status: CLOSED

There is a need to develop an autonomous, reliable, cost effective technology to map vast terrains, in terms of mineral and raw material contents which will aid in reducing the cost of mineral exploration, currently performed by ROVs and dedicated SSVs and crew. Furthermore there is a need to identify, in an efficient and non-intrusive manner (minimum impact to the environment), the most rich mineral sites. This technology will aid the seabed mining industry, reduce the cost of exploration and especially the detailed identification of the raw materials contained in a mining sites and enable targeted mining only of the richest resources existing. The ROBUST proposal aims to tackle the aforementioned issue by developing sea bed in situ material identification through the fusion of two technologies, namely laser-based in-situ element-analyzing capability merged with underwater AUV (Autonomous Underwater Vehicle) technologies for sea bed 3D mapping. This will enable resource identification done by robotic control enabled by the synergy between AUV hovering and manipulator capabilities. The underwater robotic laser process is the Laser Induced Breakdown Spectroscopy (LIBS), used for identification of materials on the sea bed. The AUV Robotic vehicle will dive, identify the resources that are targeted for LIBS scanning through 3D real time mapping of the terrain (hydro-acoustically, laser scanners, photogrammetry) and position the LIBS in the required locations of mineral deposits on the ocean floor to autonomously perform qualitative and quantitative analyses.

Keywords: multihull auv,3d seabed mapping,volume measurement,sea bed target identification,libs,laser induced breakdown spectroscopy,sea bed mining exploration technologies
Behavior and molecular signature of Neural Stem Cells, and changes occurring during aging (NSCaging)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

In the adult neurogenic niches, neural stem cells (NSCs) generate neurons throughout life. During aging, the number of newborn neurons is clearly reduced, although it is still very debated what specifically happens to the NSCs: do they die, increase their quiescence or change their fate? It is emerging that NSCs are heterogeneous, with different subtypes, in particular quiescent and active NSCs, responding differently to neurogenic stimuli, including aging. However, due to difficulties in distinguishing NSCs subtypes in vivo, their behavior in the physiological environment, their molecular hallmarks, and especially how those are changed during aging are still elusive. These are key questions in neuroscience and stem cell biology. Thanks to the combination of the host laboratory expertise with mine, the current action proposes to develop a strategy to discriminate different NSCs in vivo and shed new light on their behavior, molecular properties and the changes occurring during life. The expected results are going to provide critical information on the regenerative potential of NSCs subtypes and on whether and how the aging phenotype can be reverted, with a consequent strong scientific and social impact.
STEM CELL MODELS TO UNRAVEL THE SUSCEPTIBILITY AND RESILIENCE TO DEVELOP HEART FAILURE (STOP-HF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1496875.0
EU funding (EUR): 1496875.0
Participants: 1
Project status: CLOSED

The overarching objective of STOP-HF is to generate human induced pluripotent stem cells (hiPSC) derived cardiomyocytes from two specific forms of heart failure (HF) with a clear trigger to unravel common pathophysiological mechanisms involved in the early development of HF. The project is focused on two specific forms of HF, both with a clear trigger: pregnancy and anthracyclines. Better understanding of early molecular pathways leading to HF and knowledge about inter-individual susceptibility is needed. For detection of early changes on a molecular level cardiac tissue is needed. Generation of patient specific cardiac cells from skin fibroblasts (hiPSC technology) is a novel and innovative approach. SPECIFIC OBJECTIVES 1. Fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytes. 2. Generate and characterize hiPS derived cardiomyocytes and endothelial cells from females with pregnancy induced HF and unravel differences on transcriptome level. 3. Generate and characterize hiPSC derived cardiomyocytes from patients with high susceptibility and resilience to develop anthracycline-induced HF and compare them on transcriptome level. 4. Integrate the results for coding and non-coding RNAs from objective 1+2 and identify overlapping pathways. 5. Validate discoveries on transcriptome level in vitro, in vivo and apply for the development of HF in the general population. WORKPACKAGES WP1: Optimize fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytes WP 2A:Validate the model and compare hiPS derived cardiomyocytes and endothelial cells from PPCM and healthy sisters on transcriptome level; WP 2B:Validate the model and compare hiPS derived cardiomyocytes from both patients with high susceptibility and resilience to develop HF after anthracyclins on transcriptome level; WP 3:Integration of transcriptome data from WP 2A+2B; WP 4:Validation of novel pathways in vitro, in vivo and new onset HF in the general population.

Keywords: induced pluripotent stem cells,heart failure,aetiology,disease modeling,3d tissue
Bridging Belief and Practice (BBP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-28
End date: 2018-03-20
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The aim of the proposed research is to bridge the gap between theoretical and empirical studies of religion, which up till now developed separately, as the studies of beliefs and the studies of practices. This will be done by means of elucidating the properties of beliefs and their relation to human embodied religious practices. . I decided to take the best of empirical investigations (phenomenology and the most prominent results of religious studies) and the best of theoretical investigation (analytic philosophy) and make a conceptual work to bridge them. As a methodological basis for this work I have chosen embodied approaches, as they present a link between phenomenological descriptions and strict analytical conceptualizations. Body is a medium between beliefs and practices, thus the concept of belief will be developed in relation to the practice with a body as a focal point and a key source of conceptualizations. The results of the research will be presented in clear-cut analytical terms, easy to use not only by empirical and theoretical researchers of religion, but also by participants of interreligious dialogue, thus contributing to mutual understanding and religious tolerance. I aim to provide a proper, detailed and accurate account of the properties of beliefs in their relation to practice by conceptualizing the results of empirical studies in clear-cut analytical terms. This project is an important step in my professional development, as for its fulfillment I will have to apply all my previous knowledge and interdisciplinary skills, and learn new analytic methods.

Keywords: religion,embodied approaches,analytic philosophy,belief,practice,lived religion
Routing Energy Transfer via Assembly of Inorganic Nanoplatelets (RETAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-16
End date: 2020-07-15
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Investigation of artificial light-harvesting systems is an important part of the European research effort towards the development of sustainable and carbon-free energy sources. This research proposal aims to develop a new type of semiconductor heterostructures – solution-processed nanoplatelet assemblies capable of harvesting and transferring energy of light similar to antenna complexes of photosynthetic organisms. Towards this goal, the research project will use quantum-confined 2D semiconductor nanoplatelets arranged into superplatelet structures by means of colloidal self-assembly. The 2D nanoplatelets, which can be thought of as giant artificial chlorophyll molecules, have superior optical properties and enable the design of hybrid materials with absorption spectrum covering energy range from ultraviolet to near-infrared by mixing and matching lead halide-based perovskites with II-VI and IV-VI binary semiconductors. The proposal consists of three key parts. First, 2D nanoplatelets with optimized properties are obtained and tuned via chemical synthesis. Second, anisotropic interactions between 2D nanoplatelets of dissimilar materials are exploited for nanoplatelet assembly into heterostructured ribbons and layers. Third, the figures of merit for energy transfer and charge separation in the assemblies are obtained by spectroscopic, photochemical and photoelectric characterisations. The resulting assemblies would constitute a new class of artificial excitonic materials, expanding the family of optoelectronic heterostructures beyond epitaxially grown semiconductors and mechanically stacked exfoliated 2D materials. The proposed research project combines the strengths of the experienced researcher and capabilities of the host institution in a complementary fashion, assuring mutual benefit from the Fellowship and providing the experienced researcher with opportunities to achieve a high level of professional maturity and significantly expand his career opportunities.

Keywords: nanoplatelets,self assembly,heterostructure,energy transfer,perovskites,semiconductors,light harvesting
The sound of special places: exploring rock art soundscapes and the sacred (ARTSOUNDSCAPES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2239375.0
EU funding (EUR): 2239375.0
Participants: 1
Project status: SIGNED

The ARTSOUNDSCAPES project deals with sound, rock art and sacred landscapes among past hunter-gatherers and early agricultural societies around the world. The potential of sound to stimulate powerful emotions makes it a common medium for conferring places with extraordinary agency. Ethnographic and ethnohistorical sources indicate that these sites are often endowed with a sacred significance and, in many cases, they also receive special treatment, including the production of rock paintings. Despite the aural experience being an integral component of the human condition and a key element in ritual, archaeology has largely been unable to study it systematically. Rock art landscapes are no exception and, although some studies have been made, they have largely been reproached for their lack of scientific rigour and subjectivity. ARTSOUNDSCAPES will fully address this weakness by investigating the perception of sound in rock art landscapes from an interdisciplinary approach. Borrowing methods developed in acoustic engineering, the project will assess, from an objective and quantitative perspective, the acoustic properties of rock art landscapes in selected areas around the world: the Western/Central Mediterranean in Europe, Siberia in Asia, and Baja California in North America. Human experiences associated with altered or mystical states invoked by the identified special sonic characteristics of these landscapes will be further tested by exploring the psychoacoustic effects these soundscapes have on people and their neural correlate to brain activity. The project will also thoroughly survey ethnographic attitudes to sacred soundscapes based on both current premodern societies and ethnohistorical sources. The groundbreaking combination of this array of interdisciplinary approaches will facilitate the ultimate aim of the project: to propose a phenomenological understanding of sacred soundscapes among late hunter-gatherers and early agriculturalists around the world.

Keywords: archaeoacoustics,rock art,the sacred,acoustical engineering,psychoacoustics,neuropsychology