Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pace of life syndromes in fish: harvesting effects and the role of marine reserves (BE-FISH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 230943.6
EU funding (EUR): 230943.6
Participants: 1
Project status: CLOSED

The consistency of individual variation in behavioural traits over different functional contexts is now largely recognized and it has been termed personality. Fish personality can result from adaptive processes involving life-history trade-offs or physiological constraints, and the covariation between those variables implies the existence of pace of life syndromes. Human harvest has the potential to have evolutionary impacts on marine resources by selectively removing specific life-history traits (e.g size). However, in some fishing gears, behavioural traits (e.g. activity rate or boldness) determine fish vulnerability to capture, and direct selection on behaviour can therefore drive evolutionary changes in the whole suite of pace of life syndromes, impacting the productivity and sustainability of the resource. Fisheries managed on the basis of demographic considerations alone therefore ignore the potential for evolutionary changes. In theory, populations harboring different behavioural types are expected to be more resilient to environmental change because that diversity will be able to cope better with novel conditions. Marine reserves are considered a promising tool for conservation and fisheries management, since they may help to counter fisheries-induced evolution on life-history and behavioural traits being a potential tool for managing evolving fish stocks. However, marine reserves may also set up new selection pressures on fish behaviour in the same or in opposite direction to fisheries induced evolution (e.g. sedentary fish), potentially affecting the productivity of the resources through pace of life syndromes selection. This proposal aims to explore the covariation between life-history, physiological and behavioural traits in fish and the impact of human harvesting and marine reserves on them, making use of state of art methods and technology, with the objective of increasing our understanding of ecosystem functioning to sustainably manage fish stocks.

Keywords: fish behaviour,fisheries management,marine reserves,fisheries induced evolution,evolutionary ecology,pace of life syndromes
Identification, characterization and mechanisms of action of new tumor-associated lymphangiogenesis inhibitors (TUMORLYMPHAINHIBIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

Cancer and tumor metastasis is the largest single cause of death in both, men and women, claiming over 7 million lives each year worldwide and, it is expected that by 2020 the number of dead cancer patients will grow to 10 million per year. Metastatic tumor cells utilize blood and lymphatic vessels as routes for dissemination and it is well known that lymphatic vasculature serves as a major route for tumor metastasis. Besides, lymphangiogenesis, the new lymphatic vessels formation from pre-existing ones, is pivotal for cancer cells spreading from primary sites to lymph nodes and, further, to distant tissues. Consequently, the search and identification of new tumor-induced lymphangiogenesis inhibitors and the understanding of their mechanisms of action, are a hot topic in the field of pharmacological research. In the present project, the applicant will finished the characterization of two marine compounds, toluquinol and AD0157, started during a short stay in the host institute. Preliminary results have shown that both compounds have excellent antilymphangiogenic properties in in vitro and ex vivo assays and, in the course of the present project they will be tested in in vivo models and their molecular targets will be revealed. Furthermore, other two new marine compounds will be analyzed in in vitro, ex vivo and in vivo experimental approaches. In these studies the applicant will focus in the behavior of the lymphatic endothelial tip and stalk cells, in order to shed light on their morphological and biochemical features. Hence, this project will increase significantly the acquisition of innovative knowledge on lymphangiogenesis phenomenon, on the different lymphatic endothelial tip/stalk cells features and on the cellular and molecular mechanisms of action of some natural compounds to inhibit tumor-related lymphangiogenesis. Those compounds with excellent antilymphangiogenic properties will be patented in order to be commercially exploitable as antitumor drugs.

Keywords: lymphangiogenesis,lymphatic endothelial cells,tumor environment,tumors,metastasis,drug discovery,antilymphangiogenic.
Novel antiferroelectric glass-ceramics for energy storage applications (NAGCESA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 179739.6
EU funding (EUR): 179739.6
Participants: 1
Project status: CLOSED

The proposed training-through-research programme aims to develop novel materials for energy storage applications that would overcome the performance limitations related to the existing materials systems. This will be tackled by fabricating and characterizing recently discovered ABC antiferroelectrics which have never been previously synthesized. The novel materials will be studied in their crystalline form, and additionally glass-ceramics with the coexistence of ABC crystalline and glassy phases will be sintered and characterized, with the aim of improving electrical breakdown strength and energy density properties. The fellowship programme contains a series of complementary experimental training and several activities that will strengthen dissemination, project management and leadership skills of the fellow and it represents an excellent opportunity to prepare the ground for an independent research career. The exploitation of the present research is ensured by a solid scientific and industrial network connected to the fellow and to the host institution.

Keywords: energy storage capacitors,novel antiferroelectric,abc antiferroelectric glass-ceramics
Robust N-donor ligand based Metal-Organic Frameworks (MOFs) for capture and degradation of harmful gases and volatile organic compounds (VOCs). (DUSTBINMOF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 230036.6
EU funding (EUR): 230036.6
Participants: 1
Project status: CLOSED

Environmental pollution has progressively increased, becoming today a real danger for nature and particularly humankind. Nanoporous solids, in particular Metal–Organic Framework (MOFs), have shown to be materials with large capacities and high potentials for environmental remediation. In this regard, the outperforming adsorptive and catalytic properties of MOFs can be exploited in a synergetic way to capture and degrade highly harmful substances. The overall objective of dustbinMOF project is to develop microporous Hybrid Zeolitic Azolate Frameworks and mesoporous azolate based MOFs (i.e. MIL-101 network type) specially tailored for the removal and eventually the catalytic degradation of very harmful contaminants. The initial part of the project comprises atomistic design of the two families of MOFs. In the second stage the new ligand synthesis and functionalization will be done, followed by the synthesis of the targeted MOFs. The characterization of the prepared ligands and MOFs will encompass X-ray diffraction, thermal analysis, spectroscopic methods and pore and surface area analysis. The third stage will be focused on the adsorption of selected pollutants (NOx, SOx, H2S, HCN, VOCs, CS2, COS and chemical warfare model compounds), as a needed primary step of the environmental remediation process. The final stage will comprises the catalytic degradation capabilities of the MOFs towards the conversion of the selected pollutants into harmless substances, with the corresponding impact on environmental remediation. This project will conduct to the development of a rational design approach of MOFs for environmental remediation, making available two public libraries of new hypothetical MOFs. As an important result of dustbinMOF will be output a number of new MOFs with suitable capabilities for capturing and degrading harmful contaminants towards a healthier environment.

Keywords: nanoporous materials,metal-organic frameworks (mofs),catalysis,adsorption,pollutants,environmental remediation,nanoconfinement,materials design,degradation
Genetic map of European butterflies: Continental-scale cryptic species assessment and comparisons to North America and Australia (EUGENMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 244233.3
EU funding (EUR): 244233.3
Participants: 1
Project status: CLOSED

There is a widely recognized need for more comprehensive understanding of patterns of global biodiversity. Such information will not only address major scientific issues, such as the factors influencing rates of speciation, but it will also add new rigor to conservation programs (a critical need given the looming extinction crisis). This project exploits the power of DNA barcoding to deliver a synoptic overview of biodiversity patterns, and focuses this analysis on butterflies as a model system because they are the most intensively studied invertebrate group in the world. Despite its capacity to contribute important insights into biodiversity, prior work on European butterflies has been restricted to investigations on single nations. The EUGENMAP project raises the scale of analysis to a continent; it will assemble a comprehensive DNA barcode reference library for all European butterflies. This work will provide unprecedented insights into patterns of genetic diversity in European butterflies, revealing cryptic taxa and factors influencing the levels of geographic differentiation in single species. DNA barcode data will be tactically supplemented with nuclear markers obtained with next generation sequencers and advanced morphometrics to obtain more detailed perspectives in cases where this is justified. Furthermore, EUGENMAP will place the results for the European fauna in a broader context by comparing them with parallel investigations on the North American and Australian faunas. This analysis will provide a near global perspective on important biological questions such as the incidence and distribution of cryptic diversity, and the effects of past climatic changes on the diversification dynamics of organisms. Through its modern, multidisciplinary, and large-scale research approach, the EUGENMAP project will represent a major advance in the global study of biodiversity and a model for implementation on other taxonomic groups.

Keywords: biodiversity,butterflies,climatic fluctuations,conservation,cryptic species,diversification dynamics,dna barcoding,genomics,morphometrics,phylogeography,europe,north america,australia.
Stochastic Optimal Planning for Renewable energy sources Integration in power Systems (SOPRIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-05-15
End date: 2018-05-14
Duration (months): 36.0
Total project cost (EUR): 270964.8
EU funding (EUR): 270964.8
Participants: 1
Project status: CLOSED

Environmental concerns and the pursuit of sustainable energy sources have resulted in policy measures toward high shares of renewable generation. However, Renewable Energy Sources (RES), such as wind and photovoltaic power generation, are non-dispatchable, variable and uncertain. Traditionally, conventional generators provide balancing reserves. The increasing share of RES results in an increasing amount of required reserves, and hence it may have an opposite effect both from an environmental and economic point of view. The latter raises the need of cheaper and environmentally friendlier reserves providers. Demand response and storage resources could be utilized to offer ancillary services including reserve provision. However, these technologies include uncertainty, mainly introduced due to human behavior and weather conditions, rendering their successful exploitation challenging. Making optimal scheduling decisions in the presence of uncertainty is a challenging problem. The core in such mechanism to assess the trade-off between optimality and reliability. The SOPRIS project aims to address this problem by providing algorithms and tools for optimal decision making in power systems with uncertainty and provide performance guarantees for the system reliability. Specifically, we propose using stochastic and optimization based techniques to address the problem of unit commitment, reserve provision and energy scheduling both on the generation and the demand side, while taking the network and reliability constraints into account. The SOPRIS project proposes additional corrective control schemes that exploit the controllability not only of the demand side but also of other network components that may not provide reserve capacity but their set-point can be modulated in a post-disturbance situation thus leading to lower operating costs. Emphasis will be also given on the tractability of the developed algorithms to facilitate their application on large scale systems.

Keywords: renewable energy integration,stochastic optimization,reliability,reserve scheduling,controllability,demand side control,storage devices,distributed optimization
Reconstructing conditions during dolomite formation in evaporative Triassic environments (TRIADOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 240733.2
EU funding (EUR): 240733.2
Participants: 1
Project status: CLOSED

Dolomite is besides calcite the most abundant carbonate mineral in the geological record. However, the conditions and mechanisms of its formation are poorly understood. Most dolomite is considered to have formed at elevated temperatures when sediments became deeply buried over geological time scales. Abundant dolomite occurs in shallow marine carbonate deposits of the ancient Triassic Tethys margin, which today forms part of the Eastern and Southern Alps. Hitherto evidence indicates that some of these dolomites are not of a burial origin, but are penecontemporaneous; i.e. they formed during or shortly after sedimentation. Such dolomites apparently formed in extremely shallow water under the influence of evaporative conditions, similar to modern examples of evaporation-induced dolomite formation. Nevertheless, the environmental conditions that prevailed in the Triassic environments remain poorly constrained. The proposed study aims at mapping penecontemporaneous dolomite in the field. State-of-the-art methodology at the University of Vienna, such as a scanning electron microscope with focused ion beam milling, will allow to differentiate individual dolomite mineral phases at sub-micron scale. Stable isotope ratios of oxygen, calcium, strontium, boron, carbon, and sulphur will be measured to trace past temperature, alkalinity, pH, and carbon sources. Moreover, laser ablation mass spectrometry will allow to measure calcium and strontium isotopes at the high spatial resolution required to characterize individual mineral phases. This study represents a novel approach towards the reconstruction of the environmental conditions during the formation of penecontemporaneous dolomite – a process, which probably was among the most important processes of carbonate deposition through Earth’s history. It will shed light on the past carbon cycle and, thus, result in a better understanding of global geochemical cycling and ocean and atmosphere dynamics through Earth history.

Keywords: dolomite,triassic,alpine,evaporative,hypersaline,alkaline,sabkha,microbial,biogeochemistry,mineralogy,diagenesis,authigenic,penecontemporaneous
Understanding tumour resistance: Receptors and signalling pathways that can lead the race against tumour angiogenesis (ALTANGIOTARGET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-16
End date: 2017-08-15
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Anti-vascular endothelial growth factor (VEGF) therapies, such as bevacizumab, inhibit VEGF angiogenic actions and are increasingly used in the clinic as anticancer regimens for a variety of tumours, among which glioblastoma multiforme (GBM), the most lethal and angiogenic brain tumour, characterized by a high degree of heterogeneity. However, resistance to anti-angiogenic therapy, which leads to ineffectiveness of the existing drugs, is often acquired and suggests that there is urgent need to identify novel targets and develop alternative or complementary therapeutic options. Previous in vitro studies of the host lab have identified a novel receptor that binds VEGF and through co-operation with alpha v beta 3 integrin, is required for VEGF-induced endothelial and GBM cell migration. This receptor also mediates VEGF effects that are not inhibited by bevacizumab, encouraging the hypothesis that its targeting might be beneficial for at least some cases of resistance development to bevacizumab. The objectives of the current application are: 1) to study how VEGF interacts with this novel receptor in several different GBM cell lines, as well as in commercially available tissue arrays containing different grades of astrocytomas, and evaluate the physiological significance of such interaction, 2) To determine the interplay between this and other VEGF receptors/co-receptors, such as VEGFR-2, alpha v beta 3 integrin and nucleolin, and elucidate the cross-talk of their signalling pathways that subsequently activate the transcription factors NFAT and AP-1 and play a role in VEGF-induced cell migration, angiogenesis and inhibition of apoptosis. The project incorporates state of the art in vitro and in vivo approaches and is based on a multitude of disciplines, in order to validate an alternative target for GBM therapy, uncover novel or poorly explored signalling pathways, and identify potential bioactive molecules to be tested as inhibitors of GBM progression and angiogenesis.

Keywords: angiogenesis,migration,apoptosis,glioblastoma multiforme,vegf,transcription factors,ca2+,tyrosine phosphatases,integrin,nucleolin (no drop down menu)
Dynamics of Phase Oscillator Networks with Generalized Coupling (GECO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2017-08-13
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The interaction of units which undergo repetitive motion is one of the fundamental schemes in nature and technology. For example these oscillations are crucial to make our hearts beat: all heart cells have to contract together at the same time. Typically, the interaction between units is assumed to be simple whereas more complicated interaction has been neglected. Understanding the dynamics of oscillatory units with complicated interaction is the main goal of GECO: what are the features of networks of coupled oscillators with generalized coupling? Of particular interest symmetric and near-symmetric systems. The understanding of these dynamical phenomena goes well beyond the results in the current literature. More specifically, GECO addresses a number of specific research questions. Why and how does degeneracy found in finite collections of oscillators for simple coupling disappear when one makes the interaction more complicated? If one allows the number of oscillators to be infinite, what dynamics are possible in this "continuum limit"? Are there any genuinely new dynamics that may emerge through more complicated coupling? Answering these questions will explore new ground in the study of coupled oscillators and may consolidate existing results and put them into perspective. The University of Exeter provides a unique research environment for GECO. A crucial part of the success is the direct, personal interaction with the scientific community at Exeter. Most important is the interaction with Peter Ashwin, the scientist in charge and a leading expert in the field. GECO does not only explore cutting edge research themes but will also give the fellow, Christian Bick, a unique perspective for his future success in academia.

Keywords: dynamical systems,phase oscillators,chaotic dynamics,emergent dynamics