Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A systems biology approach to investigate cell fate switches in intestinal organoids (SysOrganoid)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Mass spectrometry-based proteomics and next generation DNA sequencing emerged as two powerful and complementary technologies in biology. I was the first to integrate these technologies in the area of epigenetics to identify and functionally characterize proteins that interact with post-translational modifications on histones and (hydroxy)methylated DNA (so-called chromatin ‘readers’). My pioneering work revealed that an intricate networks of transcription factors, chromatin modifications and chromatin readers orchestrate dynamic gene expression programs during embryonic stem cell differentiation. The next big challenge is to understand the molecular mechanisms, which help to control maintenance and differentiation of adult stem cells as an integral part of an organ. Intestinal organoid cultures recently emerged as a paradigm to study adult stem cell maintenance and differentiation. These ‘miniguts’ can be cultured in vitro and contain all the different cell types that are present in the mouse small intestinal epithelium. Recently it was shown that small-molecule driven perturbations can be used to obtain organoids which are strongly enriched for specific intestinal cell types. This system thus provides a perfect opportunity to study for the first time and in a controlled manner, adult stem cell maintenance and (de)differentiation. Using small molecule-driven perturbations and a unique combination of ‘omics’ technologies, which are embedded in my department, I will provide a systems-wide view of the molecular (epigenetic) mechanisms that orchestrate cell fate changes in intestinal organoids. This integrative approach will identify the major regulatory networks that define the remarkable cellular plasticity of the mouse small intestinal epithelium. Beyond this basic scientific goal, our work will also have profound implications for cancer research and regenerative medicine, both of which are characterized by changes in adult stem cell homeostasis.

Keywords: interaction proteomics,organoids
In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia (AltCheM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Acute Myeloid Leukemia (AML), the most common leukemia diagnosed in adults, represents the paradigm of resistance to front-line therapies in hematology. Indeed, AML is so genetically complex that only few targeted therapies are currently tested in this disease and chemotherapy remains the only standard treatment for AML since the past four decades. Despite an initial sustained remission achieved by chemotherapeutic agents, almost all patients relapse with a chemoresistant minimal residual disease (MRD). The goal of my proposal is to characterize the still poorly understood biological mechanisms underlying persistence and emergence of MRD. MRD is the consequence of the re-expansion of leukemia-initiating cells that are intrinsically more resistant to chemotherapy. This cell fraction may be stochastically more prone to survive front-line therapy regardless of their mutational status (the stochastic model), or genetically predetermined to resist by virtue of a collection of chemoprotective mutations (the mutational model). I have already generated in mice, by consecutive rounds of chemotherapy, a stochastic MLL-AF9-driven chemoresistance model that I examined by RNA-sequencing. I will pursue the comprehensive cell autonomous and cell non-autonomous characterization of this chemoresistant AML disease using whole-exome and ChIP-sequencing. To establish a mutationally-induced chemoresistant mouse model, I will conduct an innovative in vivo screen using pooled mutant open reading frame and shRNA libraries in order to predict which combinations of mutations, among those already known in AML, actively promote chemoresistance. Finally, by combining genomic profiling and in vivo shRNA screening experiments, I will decipher the molecular mechanisms and identify the functional effectors of these two modes of resistance. Ultimately, I will then be able to firmly establish the fundamental relevance of the stochastic and/or the mutational model of chemoresistance for MRD genesis.

Keywords: hematological malignancies,acute myeloid leukemia,chemoresistance,minimal residual disease,in vivo functional screening approaches,pre clinical mouse models,new targets discovery
A new generation of microbial expression hosts and tools for the production of biotherapeutics and high-value enzymes (Secreters)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Germany,Austria,Germany,Austria,Austria,Finland,Switzerland,Belgium,Hungary,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 4087420.92
EU funding (EUR): 4087420.92
Participants: 16
Project status: SIGNED

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.

Keywords: biotechnogy,bioprocessing,recombinant proteins,biotherapeutics,industrial enzymes,esr training,microbial expression hosts,systems biology,super secretion
Wind Turbine Support Structure (WTSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Norway
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Offshore Kinetics (OK), an innovative Norwegian SME, has developed a game changing offshore floating wind turbine support structure that will optimise installation, commissioning, operation (maintenance) and decommissioning of wind farms. OKs patented column, stabilization tank, universal joint and anchor provides an effective “all in one” deployment of wind turbines. The concept is considerably more cost efficient than the leading models on floating wind turbines in the world today, and will reduce both Capex an Opex of wind farms. Offshore Kinetics’ overall objective is to upscale, demonstrate, and commercialize our patented Wind Turbine Support Structure (WTSS) solution in the offshore wind market

Keywords: offshore wind,renewable energy
Volatolomics test for the diagnosis of bovine tuberculosis (bTB-Test)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Algeria,Romania,Colombia,Tunisia,Romania,Sweden,France,United States
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 1404000.0
EU funding (EUR): 1395000.0
Participants: 10
Project status: CLOSED

Bovine tuberculosis, caused by Mycobacterium bovis and other members of the M. tuberculosis complex, is a serious global disease with significant impact on animal health, public health, and international trade. This study will focus on investigating the feasibility of a non-invasive methodology for the diagnosis of bovine tuberculosis in cattle. Our approach will be based on the detection via volatile organic compounds of the disease fingerprint in several non-invasive samples, employing analytical methods and chemical sensing devices.

Keywords: metabolomics,biomarkers,breath,skin headspace,faeces,electronic nose,bovine tuberculosis
European Multimodal Metaphor in Advertising (EMMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-05
End date: 2017-10-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Metaphor and metonymy are key tools in communication, particularly when abstract ideas or emotions are discussed. While extant literature addresses metaphor in language and images, little has dealt with the combination of metaphor and metonymy in the multimodal context of advertising, where they play a key role. The EMMA fellowship aims to redress this by testing figurative complexity and emotions, the impact of these on comprehension, accuracy of interpretation and advertising effectiveness. It involves an interdisciplinary study that combines cognitive and physiological psychology with linguistic and marketing interpretations. A mixed-methods approach of lab experiments and qualitative inquiry will assess the speed and depth of comprehension, the perceived appeal, and the physiological effect of static and video advertisements on participants from three linguistic and cultural backgrounds (English, Spanish, and Chinese). If advertisers, charities and NGOs target, and are sensitive to, linguistic and cultural differences in metaphors, local and international communities can benefit from specific, appropriate and ethical advertising. The fellow will benefit from involvement in a cutting-edge study and secondments both at a leading research institute in The Netherlands an two advertising companies in Spain.
Dynamic Properties of Ferroelectric III-V MOSFETs (DYNAMISM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The discovery of ferroelectric characteristics in annealed HfO2–based films opens a wide range of applications not only in memory and logic, but the results will enable new scientific directions for instance in reconfigurable electronics. So far, ferroelectric films have been investigated in metal-insulator-metal structures suitable for back-end-of-line integration. They have also been introduced onto Si and two-dimensional materials. However, there is a gap of knowledge with lack of science and technology for integration of HfO2–based ferroelectric films on III-V channel materialswhere the increased permittivity will improve electrostatics. III-V transistors hold a key position for high-performance millimetre wave electronics. The high electron mobility in III-V materials contributes to a high transconductance that enables high unity-current-gain cut-off frequency and unity-power-gain cut-off frequency, fT and fmax, more than a factor 3 higher than competing Si MOSFET technologies. The wide options for heterostructure design have enabled III-V steep-slope transistors for low-power electronics operating down to 30 mV/dec without hysteresis . To research for the first time ferroelectric films integrated on high-performance III-V devices at technology-relevant dimensions, we will use our demonstrated integration of Hf0.5Zr0.5O2 on InAs: - Establishing the best strategy to integrate ferroelectric gate-stacks on III-V materials with strong polarization and long endurance. - Characterizing the dynamic properties with non-volatile functionality of ferroelectric films integrated on III-V transistor channels. - Investigating ferroelectric III-V MOSFETs for future applications including millimeter-wave devices, cryogenic electronics, Negative Capacitance FET (NC-FET) circuitry, and Ferroelectric Tunnel Junctions (FTJs). Combined, the new science and technology will enable novel high-performance devices as well as reconfigurable millimetre-wave electronics.

Keywords: iii v mosfet,ferroelectric,millimeter wave technology
Hands-free Voice-enabled Interface to Web Applications for Smart Home Environments (LISTEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Italy,Greece
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 414000.0
EU funding (EUR): 414000.0
Participants: 4
Project status: CLOSED

Nowadays, it is becoming increasingly affordable to enhance the home environment with several automation schemes, allowing remote control of e.g., heating/cooling, communication, lighting, media, etc. Such smart home functionalities are essential for people with disabilities and the elderly, as they not only provide assistive control of important everyday functionalities, but may prove to be life-saving in case of emergency. However, smart home functionalities may become useless for people who need those most, if they cannot be accessed via a natural, easy to use, interface. The central objective of LISTEN is to design and implement a complete system, including both the software and hardware components, enabling robust hands-free large-vocabulary voice-based access to Internet applications in smart homes. This would allow the users to have natural control (i.e., using their voice) of the smart-home web-enabled functionalities (e.g., turning on/off web-enabled “smart” appliances), but also to access specific Internet applications (e.g., web search, email dictation, access to social networks). A truly hands-free system operation of the voice interface is equally important: users will not have to turn towards a microphone or other device, or wear a headset. Therefore, LISTEN will develop (a) a robust hands-free speech capture system operating as a wireless acoustic sensor network (WASN), specifically designed for the smart home, and (b) a large-vocabulary automatic speech recognition system optimised for accessing web applications and controlling web-enabled smart home automation functionalities. LISTEN pushes the boundaries of current state-of-the-art by bridging the gap between the acoustic front-end and automatic speech recognition research communities, with the common goal of developing a smart-home-specific natural voice interface to web services.

Keywords: acoustic sensor network,automatic speech recognition,smart home environment,voice interface
ENERGY use for Adaptation (ENERGYA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy,Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-07-31
Duration (months): 65.0
Total project cost (EUR): 1495000.0
EU funding (EUR): 1082187.5
Participants: 2
Project status: SIGNED

ENERGYA will improve our understanding of how energy and energy services can be used by households and industries to adapt to the risk posed by climate change. Specifically, the project will develop an interdisciplinary and scalable research framework integrating data and methods from economics with geography, climate science, and integrated assessment modelling to provide new knowledge concerning heterogeneity in energy use across countries, sectors, socioeconomic conditions and income groups, and assess the broad implications adaptation-driven energy use can have on the economy, the environment, and welfare. The key novelty of ENERGYA is to link energy statistics and energy survey data with high spatial resolution data from climate science and remote sensing, including high-resolution spatial data on meteorology, population and economic activity distribution, electrification, and the built environment. ENERGYA has three main objectives. First, it will produce novel statistical and econometric analyses for OECD and major emerging countries (Brazil, Mexico, India, and Indonesia) to shed light on the underlying mechanisms driving energy use. Second, it will infer future potential impacts from long-run climate and socioeconomic changes building on historical empirical evidence. Third, it will analyse the macro and distributional implications of adaptation-driven energy use with an economy-energy model characterising the distribution of energy use dynamics across and within countries. Given the central role of energy as multiplier for socioeconomic development and as enabling condition for climate resilience, the research proposed in ENERGYA will result in timely insights for the transition towards sustainability described by the Sustainable Development Goals adopted by the United Nations as well as the Paris International Climate Agreement.

Keywords: climate change,adaptation,energy,scenarios,econometrics
automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Austria,Cyprus,Greece,Greece,Greece,Netherlands,Netherlands,United States,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1214400.0
EU funding (EUR): 1214400.0
Participants: 13
Project status: CLOSED

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures. During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE). HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.

Keywords: epilepsy,hfos,neuroimaging,neuroscience,seizure onset zone