Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Technologies of Electrochemical Suppression and Electromagnetic Decomposition for NOx Reduction in Aeroengines (DENOX)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Ukraine
Call: Innovative NOx Reduction Technologies (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 997500.0
EU funding (EUR): 997500.0
Participants: 2
Project status: SUSPENDED

DENOX project aims to develop and experimentally prove two breakthrough technology concepts and their optimal combination for drastic reduction of NOx emissions in aeronautic gas-turbine engines (GTEs). Technology concept 1 is electrochemical suppression of NOx generation in primary combustion zone. It consists in generation of modulated discharge(s) in combustion chamber to initiate chemical reactions competitive to conventional NOx generation mechanisms. Technology concept 2 is electromagnetic decomposition of NOx molecules in engine exhaust. It consists in application of multi-frequency electromagnetic fields to the exhaust flow to ensure resonance excitation of chemical bonds in NOx molecules up to their dissociation. DENOX technology concepts are underpinned by the results of KhAI’s theoretical investigations and numerical studies of high-temperature high-pressure low emission combustion processes, which demonstrated potential to decrease NOx concentration in exhausting gases on 20-95% without decreasing of engine efficiency. The project will combine analytical studies and numerical simulations with experimental investigations and multi-level testing campaign to translate proposed technology concepts from TRL1 to TRL3 and to assess full potential of their combination for the next-generation GTEs. DENOX outcomes will contribute to the advancement of aircraft engines in both (i) mid-term perspective (EIS 2035) through progress in understanding and modelling of high-temperature low emission combustion processes, and (ii) long-term perspective (EIS 2050) through the potential to drastically reduce NOx emissions to meet Clean Sky 2 High Level Objectives and ACARE SRIA goals.

Keywords: nox reduction,low emission combustion,electrochemical suppression of nox molecules,electromagnetic decomposition of nox molecules,combustion process modelling,chemical kinetic mechanisms
Mechanism of DNA-protein cross-link repair in S phase (DPC_REPAIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1498856.0
EU funding (EUR): 1498856.0
Participants: 1
Project status: CLOSED

DNA-protein cross-links (DPCs) are common DNA lesions caused by endogenous, environmental, and chemotherapeutic agents. Cells are susceptible to these lesions during S phase, as DPCs impede replication fork progression and are likely to induce genomic instability, a cause of cancer and aging. Despite its relevance to human health, the repair of DPCs is poorly understood. Research on DPC repair has mainly involved testing cellular responses to compounds such as formaldehyde, but these agents induce a wide variety of DNA lesions, and conflicting results have been reported. To overcome these obstacles, I have developed the first in vitro system that recapitulates replication-coupled DPC repair. In this system, a plasmid containing a site-specific DPC is replicated in Xenopus egg extracts. Using this approach, I demonstrated that DPC repair requires DNA replication. When a replication fork encounters a DPC, the DPC is degraded into a peptide-adduct, which allows replication bypass by translesion DNA synthesis. Importantly, these experiments identified a novel proteolytic pathway whose activity is regulated by replication. This in vitro system now provides a powerful means to identify and characterize the different factors that participate in S phase DPC repair. I speculate that for DPC processing to occur, the protein-adduct must first be detected, then marked for degradation and ultimately degraded. Using a series of complementary strategies, which will take advantage of the in vitro system combined with proteome and genome wide approaches, I seek to uncover the different players that participate in each of these events. This project will enable a detailed mechanistic outlook of a complex multi-step reaction that has not been feasible to achieve using existing methodologies. It will also improve our understanding of how DPCs impact genomic stability and the consequences of not repairing these lesions for human health.

Keywords: dna cross link repair,dna replication,protein degradation,ubiquitin signaling
Digital Network Management Services (PJ09-W2 DNMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Spain,Ireland,Italy,Croatia,Switzerland,Croatia,Lithuania,Slovakia,Sweden,Norway,Poland,Belgium,France,France,France,France,Czechia,Denmark,United Kingdom,Portugal
Call: PJ.09 W2 Digital Network Management Services (H2020-SESAR-2019-1, 2019)
Start date: 2019-12-01
End date: 2023-03-31
Duration (months): 40.0
Total project cost (EUR): 23794460.75
EU funding (EUR): 6735749.66
Participants: 29
Project status: SIGNED

Project PJ09, Digital Network Management Services is focusing on improvement of the network traffic prediction for all DCB (Demand Capacity Balancing) actors, dynamic airspace configurations, integrated network management and ATC planning (INAP) and collaborative network performance management. This project is structured along 3 solutions: Solution 44 Dynamic Airspace Configurations (DAC) will address the user acceptability and operational feasibility of the proposed DAC solutions and it will focus on integration of the DAC with DCB. Solution 45 Enhanced Network Traffic Prediction and shared complexity representation aims to develop the multi-layer traffic prediction model improving the forecast in pre-tactical, early D day, tactical and execution time horizons. Solution 49 will validate an operational states prediction algorithm to anticipate the performance degradation in identified areas within the network. It will also validate the transition from local to regional measures in critical state.

Keywords: atm network management nm dcb dac inap
Semantic Web for Information Management in Energy Efficient Buildings (SWIMing)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Coordination and support actions
Partnership: EeB (cPPP)
Countries involved: Germany,Ireland,Ireland,Greece,United Kingdom
Call: Support for the enhancement of the impact of EeB PPP projects (H2020-EeB-2014, 2014)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 499125.0
EU funding (EUR): 499125.0
Participants: 5
Project status: CLOSED

Energy consumption over the whole Building Life Cycle (BLC) is difficult to monitor and predict due to the complexity of the processes involved. Building Information Modelling (BIM) is a concept which has arisen to address the management and interoperability of the data exchanged between different computer aided tools employed at different stages the BLC, including design, construction, commissioning, operation, refurbishment and demolition. BIM therefore plays a key role in all aspects of energy management across the BLC. The W3C Data Activity makes use of Linked Data, which is a structured form of data storage, distributed across the web, and which is supported by tools to easily query that data. By integrating BIM into the wider web of data, building information can be queried alongside all other Linked Open Data (LOD) sources, which include data on materials and systems (e.g. sensor and state of building devices data) which make up the building, profiles of occupants, and information about weather patterns and regional and global energy prices. Together this information can make for more meaningful analysis of energy consumption and its relation to the localised costs of materials, systems and personnel in existing and future buildings. Therefore, by using BIM and LOD technologies EeB projects will be better able to exploit their results beyond their own particular stage in the BLC and as a result benefit from greater overall impact. The ‘SWIMing’ project will bring together existing EeB projects under clusters categorised by which stages of the BLC the project is applied and energy savings are achieved and the particular domains within those stages to facilitate knowledge sharing and increase the impact of project results. It will support making the project processes and the data produced by these processes publishable as linked data on the web and through this structured format (BIM-LOD), make data more accessible and less fragmented across the BLC.

Keywords: building life cycle energy management,interoperability,data management,building information modelling,linked data,ontologies,semantic web
Single-cell temporal tracking of epigenetic DNA marks (EpiTrack)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Lithuania
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: CLOSED

Over the past decade, epigenetic phenomena have taken centre stage in our understanding of gene regulation, cellular differentiation and human disease. DNA methylation is a prevalent epigenetic modification in mammals, which is brought about by enzymatic transfer of methyl groups from the S-adenosylmethionine (SAM) cofactor by three known DNA methyltransferases (DNMTs). The most dramatic epigenomic reprogramming in mammalian development occurs after fertilization, whereby a global loss of DNA methylation is followed by massive reinstatement of new methylation patterns, different for each cell type. Although DNA methylation has been extensively investigated, key mechanistic aspects of these fascinating events remain obscure. The goal of this proposal is to bridge the gap in our understanding of how the genomic methylation patterns are established and how they govern cell plasticity and variability during differentiation and development. These questions could only be answered by precise determination of where and when methylation marks are deposited by the individual DNMTs, and how these methylation marks affect gene expression. To achieve this ambitious goal, we will metabolically engineer mouse cells to permit SAM analog-based chemical pulse-tagging of their methylation sites in vivo. We will then advance profiling of DNA modifications to the single cell level via innovative integration of microdroplet-based barcoding, precise genomic mapping and super-resolution imaging. Using this unique experimental system we will determine, with unprecedented detail and throughput, the dynamics and variability of DNA methylation and gene expression patterns during differentiation of mouse embryonic cells to neural and other lineages. This project will give a comprehensive, time-resolved view of the roles that the DNMTs play in mammalian development, which will open new horizons in epigenomic research and will advance our understanding of human development and disease.

Keywords: dna methylation,droplet microfluidics,synthetic cofactor analogs,genome editing,single cell epigenome analysis,metabolic engineering
Stressfully Transmitted Diseases: How your partner’s past stress affects your current and future health (STressD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2021-08-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Early-life stress can reduce the lifespan of individuals and recent work shows that this lifespan reduction can be transmitted to reproductive partners. However, the mechanisms that allow early-life stress to damage the health of individuals that did not experience early-life stress themselves have been little studied. The overall aim of this proposal is to examine how the negative effects of early-life stress on longevity are transmitted to social partners, with focus on the neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis. The research objectives are: 1) To determine whether partners become hormonally and behaviourally similar to early-life stressed individuals; 2) To determine whether early-life stressed individuals adversely affect the health of their reproductive partners by ineffectively buffering their partners against stress; 3) To examine whether being paired to a partner that has experienced early life stress influences immune function, oxidative stress, and telomere loss. The experienced researcher will be trained by the host in adopting a life history approach to early-life stress and parental care and learn new skills in several areas of physiology and molecular biology to carry out these objectives. She will be trained to combine studies at different biological levels ranging from the molecular to the individual. This training will enhance the experienced researcher’s knowledge in different biological domains and greatly enhance her chances of starting her own independent research group in the EU.

Keywords: early life stress,glucocorticoids,hpa axis,oxidative stress,telomeres,life history strategy,social affiliative behaviour,parental care
Nite Carbon Nanoclusters, a natural antioxidant for the food industry made from agricultural waste (NCN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: SIGNED

The control of lipid oxidation in the food industry represents an important factor that affects food quality, nutrition, safety, colour and consumers’ acceptance. With the growth in the ready to eat food market, consumers are exposed to increasing doses of additives, with the average customer consuming 3.6-4.5kg of food additives yearly. The use of common antioxidants E320 and E321 (BHA and BHT), has become a controversial issue because of adverse toxicological data. Manufacturers face an ongoing challenge, as customers perceive the additives that function as effective antioxidants in food systems to be artificial and potentially detrimental to their health, whereas naturally derived compounds are readily accepted . However, since production cost of synthetic antioxidants is much lower in comparison to natural antioxidants, it is expected that the synthetic antioxidants industry will remain dominant in the global market during the period of 2014 to 2020. Nevertheless, ‘European demand for natural antioxidants for shelf like extension has boomed in recent years, and revenues for natural varieties are set to outstrip those from synthetic equivalents on the back of consumer demand for natural ingredients and nowadays account for a little over 30% of the market, a noticeable increase from previous years. Our company has identified a solution that bridges the gap in the market, developing a natural antioxidant, that provides superior performance to synthetic counterparts, at a cheaper price. Our proprietary process involves the use of waste material of grape seed to produce water soluble Nite Carbon Nano-molecules able to induce cytoprotective antioxidant effect, and potential bio-applicability as a free radical scavenger in biological systems, in oxidative stress. Our product (Vegetable Carbon and Anthocyanins by Vitis Vinifera) is already included in the "positive list" of Regulation EC 1333/2008

Keywords: antioxidants,natural process,food industry,plant waste,free radicals,oxidation
Cork Discovers: Discover your changing world (Cork Discovers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland,Ireland,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-05-31
Duration (months): 12.0
Total project cost (EUR): 193485.0
EU funding (EUR): 193485.0
Participants: 6
Project status: CLOSED

Cork Discovers aims to create a fun, interactive and thought-provoking world of research for European Researchers’ Night (ERN) 2020. The theme of the 2020 event is change. An event that promises to be fun for all the family, people will be invited to ‘discover their changing world’ (figure 2) and explore the positive changes research has made and continues to make to our daily life. Our proposed event is an evolution of the Cork Discovers project which ran its first ERN in 2018 and whose public awareness campaign has reached almost 200,000 people. Our ambitious aim is to build on our existing brand to present a significantly bigger and better ERN this year. It will: • Expand to a two-day event with an exciting programme planned for Saturday for the first time • Further geographic reach by spreading beyond Cork City and county to 5 new sites throughout Ireland • Feature an 1) innovative schools’ programme including pre-events and workshops and a 2) novel citizen science project that is ‘co-designed’ with local schools • Embark upon a new strategy of ‘research by stealth’ to significantly increase and diversify its audience Our largest ERN programme to date will showcase the wonderful research being undertaken in Cork and further afield and will demonstrate the varying ways in which research effects change. A dedicated strand of the programme will focus on sustainability research to reflect the strength of our partner organisations in this area and to respond to public interest in the topic. We will go beyond simply showcasing research. We will lead by example by ‘going green’ in 2020 developing an event that is sustainable from conception to fruition and taking steps to limit the environmental impact as much as possible.
SIMPLA - Sustainable Integrated Multi-sector PLAnning (SIMPLA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Spain,Spain,Italy,Italy,Austria,Bulgaria,Croatia,Romania,Croatia
Call: Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 1481335.0
EU funding (EUR): 1481335.0
Participants: 17
Project status: CLOSED

SIMPLA responds to topic EE 7 ‘Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures’ and its ultimate goal is empowering public authorities to develop, implement and finance sustainable energy policies and actions by creating the conditions for a smart integration between SEAPs (Sustainable Energy Action Plans) and SUMPs (Sustainable Urban Mobility Plans) - or similar plans - in cities, towns and their aggregations with a population between 50.000 and 350.000 inhabitants. SIMPLA’s work-plan focuses on the establishment of a network of National Focal Points (NFPs) in 6 countries (expanding to further 12 through replication actions) merging technical expertise, methodological know-how and institutional capacity of technical partners and public authorities. The NFPs realize an ambitious, innovative work-plan, encompassing capacity building and coaching (on-site and via the web), enhancement of multi-level governance looking for synergies and economies of scale, extensive involvement of public authorities and stakeholders, promotion of mutual learning and best practices. EU added value (involving countries and areas with different levels of tradition in integrated mutli-sector planning) and capitalization of previous EU-funded initiatives are among the project's guiding principles. SIMPLA thus contributes to the EU’s energy and climate targets for 2020 and beyond, reducing GHG emissions, increasing the share from RES and improving energy efficiency, focusing upon sectors with high energy-saving potential (primarily buildings, renewables for electricity production, urban freight transport and passengers’ mobility). The intensive exploitation of existing networks to promote and support the implementation of project activities in the framework of a sound and comprehensive promotion and dissemination plan helps guarantee a consistent and significant impact on a wide, relevant and varied audience.

Keywords: capacity building,public authorities,seap,sump,integrated multi sector plans,energy saving,stakeholders,financing,mutual learning,coaching