Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Astrophysics for the Dark Universe: Cosmological simulations in the context of dark matter and dark energy research (COSMO_SIMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Austria,France,France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1471382.0
EU funding (EUR): 315979.19
Participants: 3
Project status: CLOSED

The objective of this ambitious research proposal is to push forward the frontier of computational cosmology by significantly improving the precision of numerical models on par with the increasing richness and depth of surveys that aim to shed light on the nature of dark matter and dark energy. Using new phase-space techniques for the simulation and analysis of dark matter, completely new insights into its dynamics are possible. They allow, for the first time, the accurate simulation of dark matter cosmologies with suppressed small-scale power without artificial fragmentation. Using such techniques, I will establish highly accurate predictions for the properties of dark matter and baryons on small scales and investigate the formation of the first galaxies in non-CDM cosmologies. Baryonic effects on cosmological observables are a severe limiting factor in interpreting cosmological measurements. I will investigate their impact by identifying the relevant astrophysical processes in relation to the multi-wavelength properties of galaxy clusters and the galaxies they host. This will be enabled by a statistical set of zoom simulations where it is possible to study how these properties correlate with one another, with the assembly history, and how we can derive better models for unresolved baryonic processes in cosmological simulations and thus, ultimately, how we can improve the power of cosmological surveys. Finally, I will develop a completely unified framework for precision cosmological initial conditions (ICs) that is scalable to both the largest simulations and the highest resolution zoom simulations. Bringing ICs into the ‘cloud’ will enable new statistical studies using zoom simulations and increase the reproducibility of simulations within the community. My previous work in developing most of the underlying techniques puts me in an excellent position to lead a research group that is able to successfully approach such a wide-ranging and ambitious project.
Rapid Bioprocess Development (Biorapid)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Sweden,Sweden,Denmark,Denmark,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 4038971.76
EU funding (EUR): 4038971.7600000002
Participants: 9
Project status: CLOSED

Reducing lead times of new medicinal drugs to the market by reducing process development and clinical testing timeframes is a critical driver in increasing European (bio)pharmaceutical industry competitiveness. Despite new therapeutic principles (e.g. the use of pluripotent stem cells, regenerative medicine and treatments based on personalised medicine or biosimilars) or regulatory initiatives to enable more efficient production, such as Quality by design (QbD) with associated Process Analytical Technology (PAT) tools , the slow progress in the development of new bioactive compounds still limits the availability of cheap and effective medicines. In addition, the competitiveness of European (bio)pharma industry is impacted by the unavailability of suitably trained personnel. Fundamental changes in the education of scientists have to be realised to address the need for changes in the traditional ‘big pharma’ business model and the focus on ‘translational medicine – more early stage clinical trials with patients, more external innovation and more collaboration’ . These changes in education should be based on combining cutting-edge science from the early stage of product development through to manufacturing with innovation and entrepreneurship as an integral part of the training. The Rapid Bioprocess Development ITN, employing 15 ESRs, brings together industrialist and academic experts with its main aim to address this critical need by developing an effective training framework in rapid development of novel bioactive molecules from the very early stages of potency and efficacy testing to the biomanufacturing process characterisation and effective monitoring. The main focus of the research is on oncology related proteins and recombinant proteins to be used in diabetes treatment, although the resulting monitoring and modelling methods will be applicable to other bioactive molecule process development as demonstrated by validation on a range of relevant bioactives.

Keywords: bioprocess development,optimisation,high throughput,biopharmaceuticals
IONGELS: FROM NEW CHEMISTRY TOWARD EMERGING APPLICATIONS (IONBIKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Australia,Saudi Arabia,Argentina,Spain,France,France,United States,United Kingdom,Costa Rica
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1393800.0
EU funding (EUR): 1127000.0
Participants: 10
Project status: SIGNED

IONBIKE proposes a research and staff exchange program will promote international and intersectorial collatorations in the topic of “Innovative Iongels for Bioelectronics”. The european consortium is formed by 4 European beneficiaries from which three are academic institutions such as University of the Basque Country (Spain), University of Cambridge (UK) and University of Bordeaux (France) and a high-tech company in bioelectronics named Panaxium from France and 5 institutions from third countries such as CONICET (Argentina), UCIMED (Costa Rica), Deakin University (Australia), KAUST (Saudi Arabia) and Georgia Tech (USA). The project proposes an intensive research and networking program between the european and non-european institutions in the area of new materials for bioelectronics. The scientific project tries to combine in a synergic manner the unique technical expertises of the different nodes. World pioneers in the areas of ionic liquids, iongels, (semi)conducting polymers, advanced materials characterization and (bio)electronic devices will work together towards a common goal. The project will pursue the development of devices for health and fitness monitoring such as long-lasting electrodes for electrophysilogical recordings for brain, heart and muscular activity or new all-solid organic electrochemical transitors. The exchange of Know-How will promotes the development of excellence science and innovation and helps to turn creative ideas into innovative products which will be exploited by the participating company PANAXIUM.

Keywords: biopolymers,iongels,electrochemistry,bioelectronics,batteries
Non-Markovian Memory-Based Modelling of Near- and Far-From-Equilibrium Dynamical Systems (NoMaMemo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1983744.0
EU funding (EUR): 1983744.0
Participants: 1
Project status: SIGNED

Time series characterize diverse systems, examples in this proposal are: i) Proton motion in an inhomogeneous aqueous environment, ii) folding and unfolding of a peptide described by a suitably chosen reaction coordinate, iii) migration of a living cell on a substrate, iv) US Dollar / Yen exchange rate. Examples i) and ii) are close-to-equilibrium, iii) is a far from equilibrium since energy is constantly dissipated, while example iv) at first sight defies the classification into equilibrium or non-equilibrium. For the understanding, comparison, classification and forecasting of time series data, stochastic differential equations, diverse random walk models, and more recently, machine-learning algorithms are commonly used. But fundamental questions remain unanswered: Is a unified description of such diverse systems possible? What is the relation between different proposed models? Can the non-equilibrium degree of a time series be estimated? NoMaMemo provides a unified description of generic time series data in terms of non-linear integro-differential stochastic equations based on memory functions that are extracted from data. NoMaMemo accounts for non-linear and non-equilibrium effects as well as for non-Gaussian noise and connects with fundamental concepts such as equilibrium statistical mechanics, response theory and entropy production. The general formulation contains previously proposed models and thus allows their comparison, forecasting quality will be compared with modern machine-learning algorithms. NoMaMemo creates a generic platform to analyse, understand, compare, classify and predict time series data and to optimize stochastic systems with respect to search efficiency, barrier-crossing speed or other figures of merit. NoMaMemo will significantly advance the understanding of chemical reaction and protein folding kinetics, the interpretation of THz and IR spectroscopy of liquids and the analysis of living matter and socio-economic data.

Keywords: memory effects,non markovian effects,chemical reaction kinetics,protein folding kinetics,thz and ir spectroscopy
Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes (TheLiRep)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-05-01
End date: 2016-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Diabetes is a degenerative disease that affects over 350 million persons worldwide. Type 1 and type 2 diabetes are associated with either destruction or dysfunction of pancreatic insulin-producing β cells. Despite the availability of insulin as treatment to temporarily restore the glucostasis, this remedy is unable to avoid either the acute dangers of hypoglycemia or the long-term complications of hyperglycemia. Eventually, the challenge of treating diabetes centers on the replacement of pancreatic β cells. Due to serious organ shortage for pancreas transplantation, cell-based therapy represents the most promising option and different potential sources for new β cells are currently being explored, including embryonic stem cells and other cell types. A particularly attractive therapeutic strategy is to convert liver adult cells of diabetic patients into functional pancreatic β cells through lineage reprogramming. Fate conversion of liver to pancreas is conceivable for numerous physiological and developmental reasons, and, possibly, suitable for future clinical applications. My ERC-funded project (ERC Starting Grant “HEPATOPANCREATIC”) is focused on the molecular mechanisms underlying cellular plasticity between liver and pancreatic cells. This study has led to the identification of a novel factor, whose ectopic expression converts mouse liver cells into pancreatic cells. Here, we propose a defined and focused set of measures aimed at: 1) extending these findings in human liver cells to assess whether this strategy may be exploited to develop an autologous cell-based therapy of diabetes; and 2) elaborating a solid intellectual property strategy. The “TheLiRep” Proof of Concept (PoC) funding will ensure the full exploitation of the ERC idea and bridge the gap between my research and the earliest stage of a marketable innovation.

Keywords: cell therapy,liver,pancreas,lineage reprogramming,diabetes
ExploRing the surface slopes Of aSteroids (EROS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Understanding the near-surface and interior structure of asteroids is required in order to model changes to the asteroid’s trajectory, as may be necessary to deflect a hazardous asteroid, and for understanding the asteroid’s response to the landing of either humans or robots on the surface. Here, I propose to investigate the surface topography of asteroids to develop a surface slope metric that can probe the near-surface and interior structure of asteroids from shape models alone. This will provide a rapid and low-cost method to understand asteroid structure from flyby data rather than the more expensive and time-consuming rendezvous mission. By measuring the surface slopes of asteroids at the same horizontal scale we can see past vastly different asteroid sizes, which will allow many asteroids to be compared to one another in an independent manner. The proposed action is broken into three parts. The first part of the action is focused on developing a slope metric on the two asteroids that have been studied in the highest detail of any asteroids but have different interior structures, Eros and Itokawa. The second part involves investigating how sub-surface structure affects surface slope in a linked geomorphic seismic shaking model where we will be able to test the physical processes that affect surface slope. Finally, in the last part of the study, we will apply the slope metric to asteroids with low-resolution shape models to probe their interior and near-surface structure.

Keywords: planetary science,asteroids,remote sensing
Meats and Greens in Prehistoric Meals: coprolites as novel dietary proxies in early agricultural societies (MANGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-05-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: TERMINATED

The emergence of agriculture, and the associated dietary shifts, fundamentally changed how humans interacted with their environments, but the nature and timing of this process is debated. In 2019 a team of 250 scientists from across the globe published a landmark paper in Science, which synthesised current knowledge, and highlighted the early beginnings of the transformative global environmental change that is the basis of the emerging Anthropocene paradigm. This synthesis also highlighted significant gaps in our knowledge, particularly how the process varied in different parts of the world. This research will address these issues by developing an entirely new analytical approach, looking at dietary signals in human coprolites (fossilised faeces), to assess the relative contribution of animal and plant products, and cereals compared to other types of plants. Through the application of an innovative multiproxy methodology, that integrates macroscopic and microscopic analysis of contents, and lipid biomarker analysis of the ‘invisible’ residues, this project will provide a new evidence of diet in the Neolithic. We will focus on Neolithic subsistence and diet in two regions, Britain and China. These contrasting case studies reflect the expertise of the applicant and supervisor and will form the basis of future research which expands this approach to other regions. We will address a major question in Neolithic archaeology concerning the importance of cereals and how this varied in different regions within China and Britain. Our aims are to assess whether coprolites can be used to demonstrate consumption of cereals and other specific plant species, to examine how the dietary profiles of coprolites differ from thosereconstructed from other lines of evidence and to investigate the relative importance of plant and animal products in Neolithic diets.

Keywords: geoarchaeology
Feasibility study for the implementation of the production of organic, granulated enzymes for detergent application by automated solid-state fermentation and fluidised-bed technology (SSFENZYMES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Germany
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The use of enzymes for laundry was introduced in the early part of the 1900s. Since the latter part of the century, temperature stable bacterial enzymes (proteases, amylases, lipases and cellulases) are applied because of their stain removing activity. This feasibility study is based on the excellent task results of the recently finalised KBBE cooperative research project TRANSBIO 289603 which being considered as "success story" within the EC. Partner NST has produced the only directly exploitable result which is the sustainable production and application of detergent enzymes by solid state fermentation (SSF) of food processing by-products at pilot scale. The main objective of this follow-up proposal SSFENZYMES is to pave the way for the optimisation, implementation and demonstration of the most significant project result, which is the economic production of organic, but now recovered and granulated enzymes for detergent application by automated SSF, extraction and fluidised-bed granulation at industrial scale using renewable resources as substrate. The proposing SME NST has already developed a working prototype at technical scale (TRL 6). The performance of the system is very promising and product application of the enzyme preparation for stain removal gave consistently positive results compared to commercially available laundry detergents. The company now needs to analyse the feasibility of the implementation of a fully automated demonstration unit, which can produce a stable amount of detergent enzymes according to the demand of European detergent industry.

Keywords: enzyme technology,solid state fermentation,organic detergent enzymes
Terrorism pReventIon Via rAdicaLisation countEr-NarraTive (TRIVALENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Ensure privacy and freedom, including in the Internet and enhance the societal, legal and ethical understanding of all areas of security, risk and management
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Israel,Albania,Italy,Italy,Spain,Italy,Belgium,Belgium,Poland,Poland,Poland,Latvia,France,United Kingdom,Portugal
Call: Developing a comprehensive approach to violent radicalization in the EU from early understanding to improving protection (H2020-SEC-2016-2017-1, 2016)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 2720420.0
EU funding (EUR): 2720420.0
Participants: 21
Project status: CLOSED

The underlyingassumption of the project proposal, in line with the UN Security Council recommendations (Resolution n. 2178, September 2014) and the Commission “European Agenda on Security”2015-2020(28.4.2015, COM(2015) 185 final), is that in order to contrast successfully violent extremism,what is neededis a more balanced response to terrorism,combining repressive (protective) measures with preventive measures, in a comprehensive approach in collaboration withactors of civil society and the communitiesof reference, based on a firm commitment to respecting fundamental rights, promoting integration, cultural dialogue and fighting discrimination. To this end, a better understanding of factors constituting violent radicalisation in Europe is needed, which aims,through a multidisciplinary analysis,to a comprehensive view of the phenomenon, investigatingits root causes, in order to develop appropriate countermeasures, ranging from early detection methodologies to strategies, ways and techniques of counter-narrative, involving LEAs together with experts and civil society actors at local, national and European level. In addition, it is necessary to acknowledge that violent radicalization,especially in the case of jihadist extremism,goesmainly through narratives that: have specific characteristics and contents; use specific communication codes;are addressed to specific audiences; and spread in a multitude of ways, over the Internet, as well as by means of in-person communication exchanges that take place in families, schools, places of worship, local communities, etc. These narratives havebeen proven effective towards vulnerable groups such as young people, detainees, and people craving for revenge after having experienced what they perceive as injustices, either at personal or group level. Furthermore, due to this multifarious background, such extremism is characterised by single or group terrorist acts also reflecting a variety of influences and motivational dr

Keywords: semantic analysis,radicalisation narratives,radicalisation counter narratives,policies,cooperation between leas and civil society