Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Green valorization of CO2 and Nitrogen compounds for making fertilizers (CONFETI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Belgium,France,Italy,United States
Call: EIC Pathfinder Challenge: Carbon dioxide and Nitrogen management and valorisation (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 3992976.25
EU funding (EUR): 3992975.0
Participants: 11
Project status: SIGNED

CONFETI project proposes the development of a lab-scale validated innovative technology that is able to utilise and electrochemically convert CO2 and N2 directly from air or flue gases without the use of critical raw materials and using renewable energy sources. By the production of urea from N (N2 and/or NO3-) and CO2, the project aims to ensure a circular and renewable carbon and nitrogen economy by recycling and converting the NO3- not consume by the plant into ammonia or urea using photocatalytic technologies based on sunlight. The technology proposed in the current project to synthetize and deliver urea fertilizer to plants will follow sustainable agriculture models by promoting the efficiency of available resources, the sustainability of the agricultural sector, the preservation of the environment and the safety and quality of products. For many countries, agriculture is the dominant sector in developing the economy. Increasing productivity and the modernization of agricultural production systems are the primary drivers of global poverty reduction and energy.

Keywords: co2,nitrogen,urea,electrochemistry,soil fuel cells,solar photocatalysis
Enabling patient specific medicines using 3D printing in hospitals and pharmacies (PMed)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 3542500.0
EU funding (EUR): 2479750.0
Participants: 1
Project status: SIGNED

Uniform drug treatments are not always the best option for treating some patient populations – including children and the elderly. The industry now has extensive knowledge on the benefits of personalized medicines that take the age, metabolic and genetic differences of patients into account. However, until now there has not been a practical manufacturing solution to put this knowledge into wide-scale use. CurifyLabs has created a technology called MiniLab to make high-quality 3D printing of personalized medicines available on site in the pharmacies and bring industry level standards to mass customisation of medicines. In this project we will finalize a standard process for developing 3D printing compatible formulations and quality control solutions. This will make MiniLab highly scalable across different therapeutic areas.

Keywords: tailored dosage forms,automated small scale drug manufacturing,high precision dosing,mass customization,personalized medicines,3d printing
AI and machine learning assisted development of greener formulations and pharmaceutical processes based on amorphous solid dispersions (i-GREENPHARM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Thailand,Ireland,Serbia,United Kingdom,Cyprus
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 898971.43
EU funding (EUR): 772800.0
Participants: 10
Project status: SIGNED

This proposal is bringing together R&I related staff by a complementary set of participating organisations that will use multidisciplinary technological approaches to provide a proof-of concept framework for designing and introducing greener practices in pharmaceuticals. Knowledge will be transferred around the core technical activity that will be the introduction of HME as a novel production method, based on AI-ML tools and supported by environmental assessment for greener pharmaceuticals.

Keywords: ai,machine learning,hot melt extrusion,green processes,sustainability,pharmaceuticals
HOP-ON TUNGSTEN BIOCATALYSIS - HEAVY METAL ENZYMES FOR SUSTAINABLE INDUSTRIAL BIOCATALYSIS (Hop-on W-BioCat)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Poland
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 491758.75
EU funding (EUR): 491758.75
Participants: 2
Project status: CLOSED

To create a sustainable chemical industry in Europe, we need to harness innovative breakthrough technologies. Industrial biotechnology is already making strides in chemical manufacturing by offering processes that are more efficient, specific, safer, and less energy-intensive. However, the industry faces a limitation: there are not enough types of enzymes being used. The W-BioCat project aims to expand the range of enzymes available, specifically by focusing on tungsten-containing enzymes (W-enzymes). W-enzymes have the ability to facilitate complex chemical reactions, particularly those that involve low redox potential reductions. Unfortunately, producing these enzymes on a large scale and at a reasonable cost has been a challenge. To overcome this, we plan to produce W-enzymes using an industrially friendly microorganism, E. coli. One big hurdle is the difficulty of synthesizing the tungsten cofactor for these enzymes. We're addressing this issue through advanced computational enzyme design techniques. Our goal is to create a completely new pathway for producing the tungsten cofactor in E. coli. With Hop-on W-BioCat, we will introduce a new W-enzyme expression system using the microorganism Aromatoleum evansii. This system has already proven effective in producing W-enzyme AaAOR from Aromatoleum aromaticum. Notably, AaAOR can oxidize H2, enabling it to catalyze the reduction of carboxylic acids to aldehydes or converting NAD+ to NADH. This innovation allows us to streamline the reaction, using just one enzyme instead of two to drive the process with H2. By incorporating AaAOR into our project, we gain new ways to achieve the objectives of the W-BioCat project, particularly demonstrating a hydrogen-driven conversion of oleic acid—derived from plants—into the emollient ester oleyl oleate. The expansion of the W-BioCat project with Hop-on W-BioCat offers significant synergies that will enhance our prospects to provide W-enzymes for a sustainable chemical industry.

Keywords: tungsten enzymes,cofactor biosynthesis,computational protein design,carboxylic acid reduction,fatty acids,renewable hydrogen,hydrogenase,bioinformatics
Ocean Cryosphere Exchanges in ANtarctica: Impacts on Climate and the Earth system (OCEAN ICE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Norway,Denmark,Sweden,United Kingdom,Germany,France,Netherlands,Italy,Belgium,Ukraine,United States
Call: Key oceanic and polar processes driving regional & global climate change (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 5486890.0
EU funding (EUR): 5486889.25
Participants: 21
Project status: SIGNED

OCEAN:ICE will assess the impacts of key Antarctic Ice Sheet and Southern Ocean processes on Planet Earth, via their influence on sea level rise, deep water formation, ocean circulation and climate. An innovative and ambitious combination of observations and numerical models, including coupled ice sheet-climate model development, will be used to improve predictions of how changes in the Antarctic and Greenland ice sheets impact global climate. It will make new circumpolar and Atlantic observations in observational gaps. It will assimilate these and existing data into improved ice sheet boundary conditions and forcing, producing new estimates of ice sheet melt and impacts on ocean circulation, including the Atlantic Meridional Overturning circulation. It will develop, calibrate and assess models used to predict the future evolution of the giant ice sheets. It will reduce the deep uncertainty in the impact of their melt on societally relevant environmental changes on decadal to multi-centennial time scales. OCEAN:ICE will assess the potential for passing ice sheet 'tipping points' and their consequences for ocean circulation and climate. OCEAN:ICE will raise the profile of European research through its extensive network of international collaborators, who provide scientific and logistical support. It will directly contribute to the All-Atlantic Ocean Research Alliance through observations, logistical collaboration and analysis. It will significantly advance the state-of-the-art in coupled ice sheet-climate modelling and directly contribute to international climate assessments such as the Intergovernmental Panel on Climate Change and World Ocean Assessment. It will link organically to European data centres to disseminate its data, following FAIR and INSPIRE principles. It will deliver improved assessments of European climate impacts from the melting ice sheets, with actionable risk and timescales, to policymakers and the public.

Keywords: antarctica,southern ocean,greenland,cryosphere,climate,ice sheet melt,ocean ice interaction,sea level rise,tipping points,amoc,dense water formation,climate modelling,policy information
Mechanoredox-Biocatalysis: Functional enzyme supports that harvest vibrational energy to power redox biocatalysis (VibroZyme)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2025-07-31
Duration (months): 33.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Redox enzymes are a diverse enzyme class with significant industrial potential, improving sustainability in food, fuel and CO2 conversion. However, redox enzymes need a source of energy (electrons) to power their important reactions. While nature employs electrons transferred from “cofactors” (e.g. NAD(P)H) to drive redox biocatalysis, industry translation requires the addition of sacrificial chemicals, which increases cost, waste, and purification, and impedes scalability. This project aims to develop a new method to power redox enzymes using mechanical energy and piezoelectric materials, establishing a unique research field in mechanoredox biocatalysis. Inspired by natural mechanotransduction, where living systems convert mechanical stimuli into electrochemical activity, I will employ mechanoredox materials to transform ubiquitous vibrational energy from the environment into a sustainable supply of electrons to power redox biocatalysis. I will demonstrate this technology by coupling scalable piezoelectric-polymer composites with formate dehydrogenase (FDH) as a model enzyme, for vibration-powered CO2 reduction. First, I will design, construct and optimise piezo-polymer beads and films that generate a mechanoredox potential matched to redox enzymes. Next, I will couple these materials with FDH to catalyse CO2 reduction using vibrations from pumping as mechanical stimulus. Two routes will be explored, namely mediated and direct energy transfer (MET and DET) from the stimulated mechanoredox materials, culminating in a platform technology for exploiting redox enzymes in industry. I will gain extensive scientific and transferable skills from the team of Prof. Anne Meyer at DTU and my industry partner Novozymes to support my career development, including enzyme production and immobilization, and commercialisation. VibroZyme embodies a new strategy to enhance the scalability, sustainability and productivity of redox biomanufacturing, with immense commercial potential.

Keywords: piezocatalysis
Multiphysics Modelling-Assisted Design and Operation of the Pecaths Flow Reactor with Chemical Process Integration (PeCATHS Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Türkiye
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 33.0
Total project cost (EUR): 588945.0
EU funding (EUR): 588945.0
Participants: 2
Project status: CLOSED

Through the proposed hop-on project, GUNAM will advance the scale-up of the photoelectrocatalytic reactor and link it with full process design and assessment. Its main role is to move beyond proof-of-concept devices and establish the basis for continuous operation under realistic conditions. Within WP8, GUNAM will develop CFD models coupling fluid flow, heat transfer, mass transport, and reaction kinetics to predict reactor performance and identify optimal parameters that enhance selectivity, efficiency, and stability, while also providing input for WP5 sustainability analyses. Alongside modelling, GUNAM will fabricate and test flow reactors with larger electrode areas, assessing Faradaic efficiency, stability, and thermal management. Insights from these experiments will refine the models and inform prototype validation in WP5. In parallel, GUNAM will design and assess product recovery and process integration schemes. Separation and purification strategies for FDCA, glucaric acid, and hydrogenated LOHCs will be screened, and results will feed into WP5 LCA/LCC and WP6 exploitation activities. Beyond technical work, GUNAM will contribute to WP6 dissemination and outreach through workshops, webinars, and bilingual communication in Türkiye and neighbouring widening countries, and support WP7 coordination by reporting progress, risks, and KPIs. In parallel, UJI, as coordinator, will increase its contribution to managing the integration of GUNAM by allocating extra effort to WP7 coordination, supporting WP8 investigations, aligning prototype development and sustainability analyses in WP5, and enhancing dissemination in WIDERA countries through WP6. UJI will ensure close collaboration and effective integration of GUNAM into the consortium.

Keywords: photoelectrocatalysis,flow reactor scale up,multiphysics cfd modelling,chemical process design,lohc based hydrogen storage,process integration,separation strategies,widening participation
Why evening-types accumulate health issues and die younger than others? (ChronoHealth)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Individuals differ in daily timing of sleep–wake behavior, alertness, body temperature, cardiovascular functions and hormonal secretion, having innately different circadian types from morningness to eveningness. Evening-types show poorer health already since childhood with increasing severity of health issues at adulthood with major impact on performance/wellbeing and health care burden. However, it is largely unknown WHY health issues accumulate to evening-types. It is likely that underlying factors for health differences between circadian types include interplay between biological, behavioral and environmental factors. Project uses large population-based longitudinal and cross-sectional data across life span from early childhood to old age linked to national register data, including wellbeing and health surveys, objective circadian assessment, health measurements and genetic data. I will study which environmental, behavioral and biological factors influence circadian rhythms and their disturbances throughout life span and how these moderate/mediate the association between circadian type and health/wellbeing outcomes. Focus during early childhood will be in somatic and cognitive development, during adolescence in school adjustment, life habits and somatic/mental wellbeing, and during adulthood in disorders, hospital treatments, and mortality. I will examine the role of genetic predisposition, family/school/work/social environment, life habits and behavioral schedules. Besides the unique and versatile data available for the research, novel objective tools for assessing circadian misalignment is developed in the project. Along with my expertise on circadian research, this project has versatile data and statistical power to sort out whether health issues among evening-types are more due to biological liability, such as genetic risk, or due to e.g. higher risk for circadian desynchronization as behavioral and societal schedules are in mismatch with the innate rhythms.

Keywords: chronobiology circadian rhythms sleep mental health epidemiology nutrition stress work health school wellbeing
FORUM: Formation and Organization of Markets in Ibero-American Cities – Regulation and Adaptation of Iberian Urban Models (15th-17th Centuries) (FORUM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

This project investigates the formation and regulation of spaces designated for commercial exchanges in Iberian and Ibero-American cities during the height of global trade, between the 15th and 17th centuries. It addresses a significant historiographical gap by raising an essential question: how were Iberian urban models of commercial spaces transplanted and adapted in the "New World", interacting with pre-existing indigenous practices and local contexts? The main hypothesis of FORUM is that these adaptations resulted in hybrid urban forms, where colonial markets functioned both as instruments of imperial power and as spaces for cultural negotiation and resistance. Structured around three key areas — commerce, urbanism, and architecture — the project emphasises the evolution of commercial spaces, such as squares and streets, which played a crucial role in the mercantile organisation of colonial cities. The interdisciplinary approach, combining documentary, cartographic and iconographic analysis with architectural and urban investigations, offers a comprehensive perspective on how these spaces shaped the daily life and structure of colonial cities. By reconstructing the process of implementing commercial spaces, FORUM reveals how market regulation was used as a tool to maintain social order and colonial hierarchies, while also allowing for adaptations to new economic and social realities. The project addresses a significant gap in the historiography of Ibero-American cities by innovatively investigating the interactions between European urban models and local realities, contributing to broader debates, both in academic and non-academic contexts, on the enduring impact of colonialism on our contemporary societies.

Keywords: urban history economic history commercial architecture marketplaces cultural heritage,material,visual and textual culture renaissance iberian peninsula europe america
Green and Sustainable Processes for Electrode Production (greenSPEED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Austria,Germany,Luxembourg,France,Netherlands
Call: Environmentally sustainable processing techniques applied to large scale electrode and cell component manufacturing for Li ion batteries (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 5289222.5
EU funding (EUR): 5289222.25
Participants: 11
Project status: SIGNED

Lithium-ion technology is the means to greener and more sustainable mobility and other mobile applications, but the process of cell manufacturing is still energy consuming and using environmentally harmful substances. The greenSPEED project offers solutions for new sustainable electrode and cell manufacturing processes with reduced energy consumption, lower carbon footprint and ZERO Volatile Organic Compounds (VOCs) emissions. To that aim, the project main target is developing a battery cell comprised of electrodes manufactured by innovative dry processes. Our composite cathode, based on Ni-rich NMC, is to be manufactured by scalable roll-to-roll dry electrode coating process, that fully removes the use of casting-solvents and eliminates the need of energy-intense drying-, condensate and transportation process required in state-of-the-art electrode fabrication. The greenSPEED high-capacity pure-silicon anode is to be manufactured taking full advantage of our innovative process based on Microwave-Assisted Plasma Enhanced Chemical Vapor Deposition (MW-PECVD), which deposits porous silicon directly on the copper current-collector starting from locally produced silane gas (SiH4). Moreover, the use of advanced modelling and simulation techniques including digital twins, artificial intelligence, and machine learning are to be employed to predict and optimise cell performance in early development stages, support the cell production process by virtually assessing the influence and importance of production parameters and thus minimising the number of experiments and to accelerate electrode production optimisation steps. The greenSPEED cell aims at increasing energy density (+69%) while reducing energy consumption (-32%) and costs (-21%) of production as compared to state-of-the-art Li-ion cells. The concepts here proposed have been already demonstrated at TRL 2/3 with the aim of reaching TRL 5/6 by the end of the project.

Keywords: battery,green process,sustainability,artificial intelligence,digital twin