Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Adaptive Optics-enhanced multiphoton microscopy (AOscopy)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 3451565.23
EU funding (EUR): 2416095.66
Participants: 1
Project status: SIGNED

AOscopy aims to establish, quantify and validate the value offer of next-generation multiphoton microscopy using Adaptive Optics (AO), for several applicative use cases in biology, as a key milestone for future exploitation. When targeting deep imaging of biological tissue with subcellular 3D resolution, multiphoton microscopy is the technique of choice, thanks to a unique capability to provide fluorescence images with sub-micron 3D resolution even in scattering media. Due to these features, multiphoton microscopy is widely used in application fields such as e.g. neuroscience, immunology, oncology, dermatology or developmental biology, as a key tool to enable better understanding of both morphological and functional characteristics of biological systems, with a view on improved diagnosis and therapy of multiple diseases. However, it is most of the time severely limited by the intrinsic optical inhomogeneity of biological media, which is responsible for a limitation of imaging depth and sensitivity. While AO has proven its capability to overcome this limitation, no integrated, robust AO-enhanced multiphoton microscope is currently available, as an answer to the need from biologists to routinely and easily image deeper, with enhanced contrast, and reduced phototoxicity. AOscopy will: 1. Develop a prototype of an AO-2-photon microscope, based on our recent innovations, enabling to achieve strong signal enhancement (typ. x5), at large depths in biological media (typ. ≥700µm in the mouse brain), while reducing phototoxicity; 2. Perform market/applicative tests, through the use of the prototype by representative end-users, in order to precise, quantify and validate its value offer in intended environement, for several application fields; 3.Create, structure and develop a start-up company 100% dedicated to AO-based microscopy, in order to accelerate its exploitation and adoption.

Keywords: adaptive optics,multiphoton microscopy,deep tissue imaging,brain imaging,organoids imaging
Development of Novel Desaturative Strategies for the Preparation of Aniline Building Blocks via Photoredox-Cobalt–HAT Triple Catalysis (HAT-DES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Anilines and their derivatives are integral organic molecules with application as medicines, agrochemicals and organic materials. Over the last 30 years, the Buchwald-Hartwig and Ullmann cross-couplings have dominated the area of aromatic amination. These reactions involve palladium- or copper-catalyzed C-N bond formation between a halogenated aromatic and an amine. Only aromatics that have been halogenated will react with the metal catalysts and undergo cross-coupling. Therefore, although these processes are widely used, there are 2 significant challenges associated with them: a. aromatic halogenation reactions are often problematic in terms of selectivity b. cross-coupling reactions are known to fail on complex and functionalized materials With this project we aim to provide a transformative advance in the field and demonstrate the direct conversion of functionalized N-cyclohexyl-amides, carbamates and sulfonamides into the corresponding N-aryl derivatives. To achieve this, we will use an unprecedented triple catalysis manifold based on photoredox catalysis, cobalt catalysis and H-atom transfer catalysis. This innovative catalytic system will effectively trigger desaturation of the starting N-cyclohexyl derivatives and key reactive intermediates. This research will create a novel approach for the one-step synthesis of many complex anilines from unusual precursors, which are largely commercially-available or easy to prepare. The proposal capitalizes on recent developments by the host group in aniline synthesis and dual photoredox–cobalt catalysis. The development of this innovative project at RWTH Aachen University will create new tools in bio-organic chemistry and enable the rapid and efficient preparation of high-value materials. Implementation of the project will be facilitated by the generation, transfer, and dissemination of knowledge, which will greatly enhance my future career prospects, in accordance with the enviosioned training plan.

Keywords: aniline synthesis,h atom transfer,photoredox catalysis,desaturation
Ordered dimensional distribution of 2D/3D tin perovskites for efficient photovoltaics (OrdTinPer)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Tin perovskites, with the advantages of low toxicity and superior optoelectronic properties, are regarded as one of the most promising light absorbers for application in next-generation photovoltaic technologies. Due to the passivation and protection effect via introducing low dimensional phases, two-dimensional/three-dimensional (2D/3D) tin perovskite films show great potential for achieving high-performance solar cells. However, the relatively strong Lewis acidity of Sn2+ leads to rapid crystallization and severe coupling of different dimensional phase structures, therefore resulting in random dimensional distribution for increased charge transfer barrier and inferior charge transport. To solve this, this project proposes an innovative strategy of "slow-release effect induced sequential crystallization" by using tridentate chelating agents. With this type of molecules, the strongly anchored Sn2+ could trigger slow-release effect, making the phases with different dimensionalities self-assemble in a designed and ordered way, thus slowing down the crystallization process and decoupling the formation of different dimensional phases. The objectives are to obtain high-quality tin perovskite films with in-situ growth of orderly distributed 2D-3D structure from top to bottom, thus to realize efficient tin perovskite solar cells (PSCs). This project will not only present innovative ideas and unique mechanisms for realizing sequential crystallization, but also provide effective approaches for developing efficient and stable mixed dimensional tin PSCs. Therefore, it will pave a way for achieving environmentally-friendly photovoltaics with high performance, thus benefiting the utilization of renewable energy to promote the sustainable development. Combining my experience on crystallization regulation with theoretical and technical foundations on photovoltaic devices of the host, Marie-Curie fellowship will support me to become an outstanding principal investigator in future.

Keywords: crystallization regulation,dimensional distribution,slow release effect,tin perovskite solar cells
BIODEGRADABLE PACKAGING MATERIALS ADVANCING CIRCULARITY, SUSTAINABILITY & ECO-INNOVATION (BioPackMan)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Greece,Spain,Belgium,Ireland,Croatia,Portugal,Italy,Norway,Estonia,Czechia
Call: Biodegradable polymers for sustainable packaging materials (IA) (HORIZON-CL4-2024-RESILIENCE-01-TWO-STAGE, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 9577330.0
EU funding (EUR): 7999292.51
Participants: 20
Project status: SIGNED

The design of biodegradable polymer materials (BDPM) is at the core of BioPackMan, aiming to explore an extended material design space of Polyhydroxyalkanoates (PHAs), Poly(butylensuccinate) and its copolymers (PBS, PBSA) and Polylactic Acid (PLA) to develop tailored compounds that harness synergistic effects, leading to biodegradable, recyclable packaging with application-specific mechanical strength, thermal stability, chemical resistance and gas permeability. Biodegradable compounds will be developed with tailored morphology, to meet diverse flexible & rigid packaging requirements and also embrace a ‘biodegradation as a system property’ approach from initial material and packaging design, considering specific environmental conditions for intended and unintended disposal pathways. By establishing a complete value chain (material producers, compounders, packaging converters and end users), BioPackMan aims to provide a complete set of compounds, sustainable additives and innovative processing technologies for the production of sustainable packaging demonstrators for food, home care and personal care sectors. The target is to obtain benchmark fossil-based products quality, ensuring compliance and safe use in packaging, showcasing that BDPMs can be recycled. Circularity, safety, and sustainability are considered at all stages of development through SSbD framework, and liaise with society & industry, to assure interaction, knowledge exchange and adaptation of circular business models. To secure societal impact, stakeholders will be involved early in the project to identify barriers and facilitate the adoption of sustainable practices.

Keywords: biodegradability,phas,pbs,biobased polyesters,pla blend,sustainable additives,digital tools,lifetime prediction,packaging,recycling,plant based derivates
Direct measurements of collective swimming forces at the mesoscale (SWARM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Swimming is ubiquitous in nature and crucial for the survival of a wide range of organisms. Many swimmers move together in intricate swarms, widely believed to save energy through collective hydrodynamic interactions. While the physics behind swimming and swarming of viscosity-dominated microswimmers and inertia-dominated macroswimmers has been extensively studied, little is known about the intermediate regime (~ 0.1–10 cm), where both viscous and inertial forces are important. This mesoscale is full of living organisms, such as small larvae, shrimps, and jellyfish, and the physics behind their swimming and swarming is strongly complicated by non-linear and time-dependent effects at increasing swimming speeds and organism sizes. A breakthrough in our understanding of mesoscale swarming dynamics is hindered by an absence of force-based experiments on collective mesoswimming. Here, I will perform pioneering experiments on the swimming forces of brine shrimps as model organisms. I aim to discover how they adapt their motility in different environments and perform the first direct measurements on the binary and many-body swimming and hydrodynamic interaction forces within pairs and small swarms of brine shrimps. I aim to resolve several major questions on mesoscale motility and swimming interactions, with the grand goal to discover new insights into how and why swarms of mesoswimmers are formed in nature. My experiments will open a new living matter physics research avenue at the mesoscale, and provide sensitive and important force and fluid dynamics data for theorists to use in their future models and for engineers to use in their biomimicry design of new mesorobots. The indirect impact of my work is the creation of new biomedical and engineering applications at the mesoscale, such as swallowable surgery with swarming mesorobots capable of optimising their swarm geometry to minimise power consumption in different environments.

Keywords: swimming forces,collective swimming,microswimming,mesoscale
Towards a Resilient Future of Europe (FutuRes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Poland,Belgium,Germany,Austria,Finland,United Kingdom
Call: Socio-economic effects of ageing societies (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2740550.0
EU funding (EUR): 2740550.0
Participants: 8
Project status: SIGNED

The dynamics of the ageing of European societies and potential crisis scenarios make up the two critical cornerstones for this project. First, social inequalities in old age are very much a function of choices and events made at a younger age and across the life-span, as well as of stereotypical assumptions, expectations and beliefs about the elderly, ageing and old age. Hence ageing must be viewed in terms of a life course approach. Secondly, given inherent uncertainties, new policies – and revisions of old ones – ought to be resilience enhancing. They should enable both citizens and service providers to cope and adapt to whatever the next shock will be. A focus on resilience means that policies must be thought of in terms of proactive planning, adaptability, flexibility and where possible, prevention, rather than post-hoc solutions to challenges related to the ageing of the population. But they must also factor in the way that individuals are linked through families, social networks, environment, communities, nation states and also supra-national entities, such as the European Union (EU). An important ambition of FutuRes is to establish a transdisciplinary policy lab, a platform where decision-makers from research, politics, business and civil society engage with the project and work closely together to elaborate evidence-informed solutions based on project results. The project will have direct practical value for the actual implementation of proposed policies, but will also ensure an enduring legacy. This will be achieved also by FutuRes open science practices (as laid out in section 2 in the proposal), which includes for instance the FutuRes policy review and its resulting data base, co-production efforts among participants and with non-scientific audiences.

Keywords: life course,ageism,resilience enhancing policy,policy lab,fertility,migration,dynamic general equilibrium model
Catalysing Investment into Catalan Bioeconomy via One-Stop-Shop Accelerator (BIOBOOST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Coordination and support actions
Countries involved: Spain
Call: Circular Cities and Regions Initiative’s project development assistance (CCRI-PDA) (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 1775250.04
EU funding (EUR): 1775250.0
Participants: 4
Project status: SIGNED

Catalonia offers huge potential to become a showcase for Bioeconomy innovation and deployment in Europe. The region is a hub of high-tech manufacturing, research, and industry (vehicles, chemical, health), has extensive forests (>60% coverage), agricultural production and fisheries, and it is backed by strong institutional support for the bioeconomy with The Catalan Bioeconomy Strategy launched in September 2021. However, circular bioeconomy projects involve a wide range of stakeholders, complex business models and demand strong technical and legal knowledge from developers, investors, regulators, and local planning authorities. For these reasons, many viable bioeconomy projects are overlooked and are unable to raise sufficient investment. BIOBOOST aims to accelerate the growth of the bioeconomy in Catalonia by delivering Project Development Assistance (PDA) services that address the specific and systematic barriers preventing bioeconomy projects from reaching the investment stage. PDA services will be delivered via a one-stop-shop office in Barcelona, the "Accelerator". The needs of bioeconomy projects will be assessed, Project Development Plans developed, and a package of PDA services offered. The office will also work together with the investment community and public institutions to prepare these stakeholders for investment and construction phases. PDA services will be delivered by a powerful consortium of sector specialist that bring together all the core components of successful project development: 1. Facilitation and Coordination (Symbiosis); 2. Technical Feasibility and Engineering (Aeris); 3. Legal and Public Administration (Roca Junyent); and 4. Business Develop and Financing (Inveniam). Overall, we forecast that over 30M€ of additional investment into circular bioeconomy projects will be achieved because of the BIOBOOST project, representing over a 18x multiplier on EU investment.

Keywords: bioeconomy,finance,accelerator,project development assistance,circular cities and regions initiative
Application Aware, Life-Cycle Oriented Model-Hardware Co-Design Framework for Sustainable, Energy Efficient ML Systems (SustainML)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,Germany,Denmark,France,Switzerland
Call: Verifiable robustness, energy efficiency and transparency for Trustworthy AI: Scientific excellence boosting industrial competitiveness (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-10-01
End date: 2026-06-30
Duration (months): 45.0
Total project cost (EUR): 3742855.0
EU funding (EUR): 3742855.0
Participants: 7
Project status: SIGNED

AI is increasingly becoming a significant factor in the CO2 footprint of the European economy. To avoid a conflict between sustainability and economic competitiveness and to allow the European economy to leverage AI for its leadership in a climate friendly way, new technologies to reduce the energy requirements of all parts of AI system are needed. A key problem is the fact that tools (e.g. PyTorch) and methods that currently drive the rapid spread and democratization of AI prioritize performance and functionality while paying little attention to the CO2 footprint. As a consequence, we see rapid growth in AI applications, but not much so in AI applications that are optimized for low power and sustainability. To change that we aim to develop an interactive design framework and associated models, methods and tools that will foster energy efficiency throughout the whole life-cycle of ML applications: from the design and exploration phase that includes exploratory iterations of training, testing and optimizing different system versions through the final training of the production systems (which often involves huge amounts of data, computation and epochs) and (where appropriate) continuous online re-training during deployment for the inference process. The framework will optimize the ML solutions based on the application tasks, across levels from hardware to model architecture. AI developers from all experience levels will be able to make use of the framework through its emphasis on human-centric interactive transparent design and functional knowledge cores, instead of the common blackbox and fully automated optimization approaches in AutoML. The framework will be made available on the AI4EU platform and disseminated through close collaboration with initiatives such as the ICT 48 networks. It will also be directly exploited by the industrial partners representing various parts of the relevant value chain: from software framework, through hardware to AI services.

Keywords: greener ai
Post-Quantum Networks for Energy-eXfficient Transitions (PQ-NEXT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Poland,Bulgaria,Germany,Italy
Call: Post-quantum cryptography transition (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 5998950.0
EU funding (EUR): 5998950.0
Participants: 19
Project status: SIGNED

Cryptographic technologies and encrypted channel communications have become a standard security pre-requisite among government and industry protocols, schemes and infrastructure. Practical quantum computing, when available to cyber adversaries, will break the security of nearly all modern public-key cryptographic systems. Practical quantum computing, when available to cyber adversaries, will break the security of nearly all modern public-key cryptographic systems. Consequently, all secret symmetric keys and private asymmetric keys that are now protected using current public-key algorithms, as well as the information protected under those keys, will be subject to exposure. This includes all recorded communications and other stored information protected by those public-key algorithms, the so-called Harvest Now Decrypt Later (HNDL) paradigm. Any information still considered to be private or otherwise sensitive will be vulnerable to exposure and undetected modification. Once exploitation of Shor’s algorithm becomes practical, protecting stored keys and data will require re-encrypting them with a quantum-resistant algorithm and deleting or physically securing “old” copies (e.g., backups). Integrity and sources of information will become unreliable unless they are processed or encapsulated (e.g., re-signed or timestamped) using a mechanism that is not vulnerable to quantum computing-based attacks. PQ-NEXT will focus on developing a comprehensive framework to facilitate the seamless transition to post-quantum cryptographic standards. This includes creating a catalog of PQC algorithms, maintenance tools, and a quantum programming language with advanced features like high-performance simulation and hybrid quantum-classical optimization, ensuring crypto-agility and security against quantum threats for large-scale pilots, targeting the financial, critical infrastructure, digital identities and telco industries.