Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Palaeocloud Reconstruction Project (PReP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-17
End date: 2023-06-06
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Clouds are a key component of global climate. Alteration to simulated cloud in climate models has large surface temperature effects, yet we cannot validate model predictions for the future against observations. Reconstructions of major patterns in mid-Piacenzian Warm Period (mPWP) cloud can provide critical verification data from an analogous past climate to assess the cloud prediction ability of state-of-the-art climate models, however there are no known biological proxies for cloud in deep-time. The aim of PReP is to develop proxies capable of reconstructing past cloud and to use them to establish a global cloud database for the mPWP, for testing cloud model prediction performance. The development of biological proxies for cloud characteristics in deep-time will be pursued in two streams: statistical methods – testing cloud as an emergent property of existing palaeoclimate estimates and testing the extent to which existing palaeoclimate schemes can be expanded to predict cloud – and experimental methods – investigating a novel proxy for cloud through leaf micromorphological variation under cloud-mimicking light schemes. The methods will be used to reanalyse existing data for mPWP sites with the aim of establishing a global palaeocloud dataset for model verification within the Pliocene Modelling Intercomparison Project. My experience in multiproxy palaeoclimate analysis, and Pliocene palaeoclimate specifically, combined with the interdisciplinary expertise at the University of Leeds in Pliocene climate modelling and applied statistics, and at the National University of Ireland, Galway in palaeobotany, will create the optimal intellectual environment to deliver the aims of the project. The experience of my host as a supervisor and mentor for early career researchers, and the supporting resources of the university for dissemination of results and exceptional training opportunities in both hard and soft skills, will facilitate independence in my research career.

Keywords: plant ecophysiology,cloud
Pandemics Outbreaks Rationalized: towards a universal therapy to eliminate intracellular pathogens and drug resistance (PANDORA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1495018.0
EU funding (EUR): 1194658.0
Participants: 2
Project status: SIGNED

I propose here a research vision that aims to revolutionise the way we cure infections caused by intracellular pathogens, with the aim to find a universal therapy to infectious diseases that will also counteract the development of drug resistance. In PANDORA, I will specifically focus on eradicating human tuberculosis, one of the worst pandemics so far. To do this, I will first probe what are the molecular ‘bar-codes’ of infected cells, namely those specific membrane proteins that cells express upon infection. I will use this to reversely engineer a repertoire of super-selective polymeric nanoparticles - known as Polymersomes - that will carry ligands to recognise, bind, and selectively attack infected cells only, while leaving non-infected cells completely untouched. Such nanocarriers will access the infected cells and locally deliver their payload, which is the core technology of the therapy. Such technology will be inspired by what nature invented: I will reproduce the binding sequence of autolisins, proteins expressed by bacteriophages that specifically bind the wall of Mycobacteria species (the agent causing tuberculosis). I will thus create fusion antibodies (Ab) characterized by (i) the binding sequence of mycobacteriophages autolisins (for selective recognising intracellular Mycobacterial wall) and (ii) an effector region promoting bacterial clearance through either the macrophage-triggered phagocytosis or an ubiquitin-proteasome system. This therapy will represent a complete revolution in the field of new antimicrobial development, as it will combine complete bacterial eradication, development of memory immunity and fight against drug resistance, the three core pillars of this project. The super-selective polymersomes carrying the Abs-based universal therapy will be combined with the development of chimeric antigen receptor T-cells (CAR-T) against infection. These T-cells will be designed to chase and eradicate circulating infected cells in model organism.

Keywords: intracellular pathogens,host pathogens interactions,fight drug resistance,precise nanomedicine,human,tuberculosis
European network for developing new horizons for RIs (EURIZON)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Austria,Ukraine,Germany,Germany,Germany,Germany,Italy,Germany,Belgium,Poland,Russian Federation,Sweden,Switzerland,Hungary,France,France,France,Czechia
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2019-1, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 21767360.43
EU funding (EUR): 21767360.43
Participants: 40
Project status: SIGNED

This EURIZON project proposal is about European scientific and technical collaboration in the field of research infrastructures (RIs), and it includes in addition a special focus on coordination and support measures dedicated to support Ukrainian scientists and Ukrainian RIs as well as strengthening the RI landscape in Widening Countries. EURIZON is in fact the second part, or phase, of a four-year Horizon 2020 project that started in February 2020, under the name CREMLINplus. With the war against Ukraine that has begun in February 2022, the project was confronted with an absolutely extreme case of force majeure: the home country of 10 consortium participants – the Russian Federation – has invaded its neighbour country Ukraine, and has thus brought a devastating war into the heart of Europe. At the time when writing and submitting this proposal, the war is ongoing, and an end is not yet visible. The second phase of the project will keep a very high ambition, and will go beyond the current state of the art of collaboration around RIs, that has been already achieved in the first phase. The project will operate in two directions: (1) Technology development: the project allows European collaborative excellent teams to develop and deliver finest, new cutting-edge technologies for European RI including ESFRI landmarks and for RI upgrade projects currently underway, such as 4th-generation synchrotron projects, or for the instrumentation at modern neutron sources; (2) Strengthening RI landscape in Ukraine and in the Widening Countries: a number of coordination and support measures has been introduced in the second phase of the project to specifically support individual displaced scientists from Ukraine, to train RI staff at RI from Ukraine and Widening Countries, and to explore and develop science diplomacy measures dedicated to support the reconstruction of the Ukrainian RI landscape. The 27 European participants of the project have come together to build the broad and balanced consortium. They are the relevant entities in the domain of research infrastructures in Europe, and thus provide the necessary strength, commitment and power to implement the project plan.

Keywords: research infrastructures,european russian collaboration,transnational access tna,russian megascience projects,long term sustainability lts,neutron sources,detector development,synchrotrons
Elemental Halogen-Free Reversible Construction and Deconstruction of 1,2-Dihalides via Shuttle Catalysis (HaloCat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Multi-halogenated compounds play a significant role in our daily life, as they are not only widely used as materials, pharmaceuticals, and agrochemicals but also serve as practical and indispensable building blocks in the chemical industry. However, most of the existing halogenating protocols suffer from safety risks and harsh reaction conditions caused by toxic and corrosive halogenating reagents (Cl2, Br2). Moreover, the enantioselective 1,2-dihalogenation of alkenes remains an unmet challenge. Besides, practical approaches to the versatile 1,2-bromofluorine-containing building blocks are exceedingly rare. Recently, the shuttle catalysis strategy, which reversibly transfers a chemical moiety between two molecules to construct and deconstruct compounds without handling hazardous reagents, is emerging as a potential strategy to tackle these long-standing challenges. This proposal aims to achieve the shuttle catalysis enabled reversible interconversion of 1,2-dihalides and alkenes/alkynes without using or releasing hazardous chemicals (e.g., Br2, Cl2, and BrF) under mild conditions. The first part is devoted to developing the reversible interconversion between 1,2-dihalides and alkenes. The second part aims to realize the enantioselective Br2 transfer between 1,2-dihalides and alkenes. The last part proposes to develop the unprecedented formal transfer 1,2-bromofluorination of alkenes via a unique self-correcting mechanism. The world-leading research environment of ETH Zurich combined with Prof. Morandi’s unrivaled scientific expertise on shuttle catalysis and my excellent knowledge of asymmetric catalysis offer the best combination to achieve the proposed research. This fellowship will dramatically improve my knowledge and competences, helping me launch my independent career. With promising preliminary results demonstrating the project’s feasibility, the proposed work will significantly contribute to the research excellence and sustainable development of the EU.

Keywords: carbon halogen bond formation,shuttle catalysis,reversible reaction,transfer chemistry,lewis base catalysis,halogenation,green chemistry,sustainable chemistry,2 bromofluorination
Designing the I-Do Service: Facilitating Inclusion and Empowerment of People Living with Dementia through Access to Cultural and Creative Activities (IDoService)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-19
End date: 2022-10-18
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

This fellowship will co-develop, implement and evaluate the I-Do service to increase the socio-cultural participation and empowerment of people living with mild to moderate stages of dementia (PLWD) through an interdisciplinary engaged research approach that combines service design and psychology with a co-design methodology. This user-friendly service will allow PLWD to plan, connect with and participate in tailored opportunities to realise themselves and contribute to society. The fellowship will use a co-design approach (Niedderer et al. 2019), working with PLWD, their relatives/familial carers as well as relevant stakeholders. It will develop the service model, i.e. the principles for format, content and delivery of the I-Do service, which it will implement and evaluate through a pilot in the area of Manchester, UK. The I-Do service addresses a key need of PLWD to be able to contribute and to be valued for it: Tournier et al 2017 found that PLWD are looking for more self-determination, to conduct activities on their own, to continue to learn new things and to be creative as well as to feel useful to others. This corroborates an investigation by Schölzel-Dorenbos et al. (2010) on this understudied topic, which shows that social contact, attachment, being useful/giving meaning to life, enjoyment of activities, and self-determination and freedom are key aspects of unmet needs for PLWD. I-Do will address these unmet needs through its novel interdisciplinary engaged community approach to develop the understanding of relevant and appropriate services for PLWD and to support the realisation of local and national policies regarding dementia friendly communities in the UK.

Keywords: dementia,service design,social inclusion,empowerment
Globalization, Economic Policy and Political Structure (GEPPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1080000.0
EU funding (EUR): 1080000.0
Participants: 1
Project status: CLOSED

Globalization is expanding economic borders rapidly. Barriers to trade are now lower than ever and this has led to the creation of many truly global goods and asset markets. And yet globalization is changing political borders only slowly. The second wave of globalization that started after WWII found the world organized into a set of states or centralized jurisdictions that often go beyond cultural borders but that clearly fall short of economic borders. These centralized jurisdictions still hold most of the political and decision-making power. This growing mismatch between markets and states lowers the quality of economic policymaking. Since constituencies are located inside the state, governments tend to disregard effects of economic policies that are felt beyond the political border. The result is a worsening in policymaking that could seriously mitigate the gains from globalization and even turn them into losses. The goal of this project is to improve our understanding of how this growing mismatch between economic and political borders affects economic policy and political structure. In particular, it focuses on the inefficiencies this mismatch creates and on how should we (“the citizens of the world”) handle them. The project is organized around two themes. The first one is the handling of enforcement externalities. One of the key roles of governments is to enforce contracts. When these contracts involve domestic and foreign residents, governments have the temptation to enforce selectively so as to shift income to domestic residents at the expense of foreigners. The second theme is the evolution of political structure. The world is currently organized into state or centralized jurisdictions. This project studies the hypothesis that globalization leads to an alternative political structure based on a set of overlapping jurisdictions.

Keywords: globalization,international trade,international finance,economic policy,political structure and policy externalities
Advanced Finite Element Modeling of Arterial Stent Placement Procedures (StentFEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Japan
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 36.0
Total project cost (EUR): 276274.8
EU funding (EUR): 276274.8
Participants: 2
Project status: TERMINATED

Arterial stenting has become a very important and successful intervention in vascular surgery. One of the most common scenarios includes so-called stent grafts, which are usually composed of a special fabric and supported by a metal stent mesh. Such stent grafts are used in endovascular repair (EVAR) to support weak spots and localized bulges (aneurysms) in an artery being at risk of rupture, most commonly for abdominal aortic aneurysms (AAA). The stent graft strengthens the weakened region of the arterial wall and excludes the AAA from blood flow and blood pressure. Over the last decade, an enormous thrust of research with regard to computational analysis of biomedical engineering problems in general, and with regard to hemodynamics, vascular mechanics and stent placement in particular has taken place. While significant progress has been made in all mentioned fields, computational analysis of stent placement using finite element methods (FEM) is still not predictive enough to give specific advice to vascular surgeons on how to optimally place the stent graft during EVAR. Instead, this decision is mostly based on the experience of the vascular surgeon. Risks of stent placement include a movement of the stent away from the desired location (migration), leaking of blood around stent grafts (endoleakage) and damage of the arterial wall caused by the stent itself. The main objective of the proposed research project is the development, implementation and validation of advanced FEM tools for stent placement simulation. The long-term vision is to be able to provide vascular surgeons with unprecedented predictive capabilities regarding the optimal choice of a patient-specific stent design (size, geometry, etc.) and stent positioning in order to safeguard against the risks mentioned above.

Keywords: finite element method,stents,arteries,contact mechanics,fluid structure interaction,patient specific modeling,large deformations
GoSAFE RAIL – Global Safety Management Framework for RAIL Operations (GoSAFE RAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Ireland,Austria,Germany,Ireland,Croatia,Norway,Netherlands,United Kingdom
Call: Safer infrastructure – improved object detection and prevention of safety critical events and integrated mobility (H2020-S2RJU-OC-2015-01-2, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 1298750.0
EU funding (EUR): 1298750.0
Participants: 11
Project status: CLOSED

The GoSAFE RAIL project will be transformative for asset safety in the rail sector. It will bring together inter-disciplinary experts from Risk based asset assessment of infrastructure, Artificial Intelligence (AI), object detection and data management sectors with leaders in network micro-simulation modelling to deliver a Decision Support Tool that will allow a step change for infrastructure safety. The involvement of Infrastructure Managers and Railway Undertakings will ensure the R&D performers have access to data and through collaboration with the Shift2Rail initiative and complementary H2020 projects, access to demonstration sites (a number of preferred tunnel and bridge monitoring locations have already been selected) necessary to develop the tool and a ready market to commercialise it. Through the development of a Network Decision Support Tool the project will provide integrated solutions to issues related to infrastructure safety and planning considering a number of common problems faced by EU infrastructure managers. The project aligns directly with the Shift2Rail (S2R) masterplan and the three technology demonstrator projects in the Intelligent Asset Maintenance pillar (TD 3.6, 3.7 and 3.8). In particular it will address (i) Integration of Open-Linked Data from a range of sources and transformation to allow for direct use in a safety framework incorporating network modeling, (ii) Real-time methods for object detection will be developed and demonstrated, (iii) Analytical models incorporating Artificial Intelligence (AI) algorithms will be developed to predict asset degradation and (iv) The safety framework can be used to plan maintenance and intervention strategies with the lowest whole life cycle cost.

Keywords: object detection,artificial intelligence
Whole Life Rail Axle Assessment and Improvement Using Ultrasonic Phased array and Corrosion Inspection Systems (RAAI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany,Germany,United Kingdom
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-12-01
End date: 2018-05-31
Duration (months): 30.0
Total project cost (EUR): 1574164.25
EU funding (EUR): 1101914.5
Participants: 3
Project status: CLOSED

The overall objective of the RAAI project is to develop novel NDT solutions for the corrosion assessment and crack detection as well as reliability software for high cycle variable amplitude corrosion fatigue of rail axles. Currently, the most sensitive non-destructive testing methods for inspection of rail axles are surface inspection methods designed for crack detection (such as MPI, eddy current and ACFM) and these do not typically attempt to measure corrosion. Besides current trend is that axles are withdrawn from service long before their design lives because of suspected corrosion developed on the axle surface. The decision to withdraw from service is taken without the full knowledge of the way in which the failure will result from corrosion as this requires a crack to initiate and the mechanism for this is unknown. RAAI aims to develop two novel methods: 1) corrosion assessment 2) phased array ultrasonic. The first method assesses the effect of corrosion on high-cycle fatigued component such as the axle and evaluates its remnant life thereby improving the sentencing of corroded axles. The second method is specifically for hollow axles of high speed trains and aims to improve the speed of the inspection (by 75%) and improve crack detection reliability (almost 100% with a crack of 2-3 mm depth) without dismantling the wheel-set and with minimum time of inspection. The primary impact of the project is to improve the competitiveness of the SMEs in the project by enabling them to provide NDT solutions to reducing the cost of and improving the safety margins of rolling stock operation. The consortium SMEs already have a presence in the railway inspection market and will have improved access to the €2 billion per annum market for in-service inspection equipment and services in Europe as a result of the RAAI.

Keywords: rail axle,failure analysis,corrosion,crack detection,ndt inspection