Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease (ExpoBiome)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Luxembourg
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1998620.0
EU funding (EUR): 1998620.0
Participants: 1
Project status: SIGNED

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

Keywords: chronic diseases,data integration,fasting,health,immune system,inflammation,microbiome,omics,organ on a chip,parkinson s disease,rheumatoid arthritis
Creation of the “Knowledge-Empowered Entrepreneurship Network” to position Kaunas University of Technology at the forefront of EU research in entrepreneurship (KEEN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Switzerland,Lithuania,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2021-11-30
Duration (months): 39.0
Total project cost (EUR): 991868.75
EU funding (EUR): 991868.75
Participants: 4
Project status: CLOSED

The overall objective of the KEEN project is to strengthen the research excellence of Kaunas University of Technology (Lithuania) in entrepreneurship, improve its capacities to exploit and disseminate its research outputs, and enhance its ability to engage the public in its research and entrepreneurship awareness, understanding, and acceptance. To reach such objective, the KEEN project will create with Cranfield University (United Kingdom), Bergische Universität Wuppertal (Germany), and Universität St. Gallen (Switzerland), a network named “Knowledge-Empowered Entrepreneurship Network”. The network will sustain after the project and focus on building capacities to develop public engagement in entrepreneurship research in low-innovativeness level EU countries such as Lithuania. The network will allow 1) to co-create more socially-relevant research with multiple actors such as policy makers, citizens, industrials or NGOs; 2) improve access by the public to research results; and 3) foster entrepreneurship policy development more in phase with the needs and expectations of the society. The KEEN project and afterward network will implement measures focusing on knowledge and skill development, research collaboration, engagement with stakeholders, and support of entrepreneurial initiative with relevant academic knowledge. Compared with existing entrepreneurship-support initiatives, the innovative aspect of KEEN is to focus on transfer of research knowledge to the society, which in return allows the society to be more involved in research orientation.

Keywords: twinning,social entrepreneurship,strategic entrepreneurship,innovation systems,entrepreneurial behaviour,entrepreneurial finance
NEUROtransmitter TRANSporters: from single molecules to human pathologies (NeuroTrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Italy,Austria,France,Netherlands,Denmark,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-02-01
End date: 2024-07-31
Duration (months): 54.0
Total project cost (EUR): 3994422.12
EU funding (EUR): 3994422.1199999996
Participants: 12
Project status: SIGNED

The vision of the ETN network NeuroTrans (NEUROtransmitter TRANSporters: from single molecules to human pathologies) is to (i) enable an improved understanding of how dysfunction of neurotransmitter:sodium symporters (NSS) contributes to neuropsychiatric disease pathobiology and how psychoactive substances target NSS and (ii) to establish a robust framework for comprehending these pathologies through changes in transporter function at the molecular level. The mission of NeuroTrans is to develop a solid model that can predict changes in NSS function using fundamental principles obtained from quantitative experiments using an interdisciplinary approach. NeuroTrans will have a strong translational aspect through the development of enabling techniques in biophysics, molecular and structural biology and through industrial partner which establish novel instruments for use in live cells to quantify kinetics, dynamics and thermodynamic parameters, allowing for exploitation and commercialisation. The NeuroTrans research programme will have major generalizable scientific impact that will be of high relevance to academia, pharmaceutical industry and policy makers and is likely expand not only to other classes of transporters, but to membrane proteins in general. NeuroTrans will establish a highly interdisciplinary doctoral training program by forming an interdisciplinary and intersectorial team of world-leading European researchers. Training will include most important subdisciplines in quantitative biology, including molecular modelling, computer simulations, biophysics, biochemistry, neurobiology, molecular and structural biology. Taining will be headed by an industrial beneficiary to secure a strong industry oriented focus, ensuring that the ESRs can become part of Europe’s future generation of innovative leaders, be at the forefront of science and innovation, translate fundamental research into cutting-edge technologies, and solidify European industry leadership.

Keywords: secondary active transporters,neurotransmitter transporters,monoamine transporters
THE FIRST PERCUTANEOUSLY IMPLANTABLE PADDLE LEAD FOR SPINAL CORD STIMULATION (PercPad)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 3311447.5
EU funding (EUR): 2318013.25
Participants: 1
Project status: CLOSED

Worldwide, around 1.5 Billion people suffer from chronic pain. Chronic pain undermines the ability to lead a productive working and social life, and it has significant impacts on the private and public economy. The estimated total cost for chronic pain is calculated to reach yearly as much as €455 Billion in the USA, and €300 Billion in Europe. Spinal Cord Stimulation (SCS) is a pain relief technique that consist in delivering current pulses to the spinal cord in order to block the sensation of pain. Basic SCS devices comprise implantable leads that are connected to a pulse generator controlled by a control unit. The leads currently available in the market are rather bulky and rigid, poorly stretchable and usually their implantation requires a complex chirurgical intervention. The Percutaneous Spinal Cord Stimulation Paddle Lead (SCS ExpertTM) proposed by WISE is a foldable lead fit for minimally invasive percutaneous implantation, which can be achieved by neurosurgeons and anesthetists. This innovative product addresses a key market need within the SCS segment of the growing neuromodulation market. The goal of this project (PercPad) is to complete the development of SCS ExpertTM and to prepare the path to introduce it into market by the Q4 2022. PercPad is a solid project that will generate important benefits for our company. Within a 5-year period after the launch, WISE expects cummulative gross profits of €36.2 Million, with a payback period of less than 5 years. We have identified a promising market opportunity, as the global neuromodulation market is projected to attain a value of €6.5 Billion in 2022 by rising at a CAGR of 12.5% from 2017, and our target segment is expected to cover over 1/2 of such market worth. Altogether, this represents a very promising scenario for the deployment of SCS ExpertTM and we envisage a country entry SOM of 1.6% reaching a 15% after 5 years.

Keywords: flexible electrodes for neuromodulation,chronic pain,spinal cord stimulation,non invasive surgery
Photovoltaic Control and Integration (PVCI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

According to the "Europe 202 strategy", Europe should increase the use of photovoltaics (PV) and other renewable energy sources (RES) for a sustainable future. However, to this day, PV plants are not-controllable power sources, thus imposing limits on PV penetration due to technical restrictions. The PVCI project will investigate these limitations and will provide solutions through a coordinated PV control strategy for combined frequency and voltage regulation. The two main objectives are: (a) development of a smart inverter control scheme to provide ancillary services to the grid, and (b) derivation of an enhanced network management strategy to coordinate PV plants and other network equipment for smooth and optimal grid operation. This is a holistic approach to the problem, simultaneously addressing frequency and voltage regulation, as opposed to the research made so far which treats these issues separately. The research is very timely, as the leading PV deployment faces stagnation and several European countries have already reached their upper limits in PV penetration. This project is aligned with the European strategy to be more resource efficient and less energy-dependent on other countries. The Researcher obtained very recently his PhD degree on PV modeling and control, and wishes to enhance his portfolio on the fields of distributed generation and power systems. He has derived PV models that will be useful for this research and has already started investigating these topics, while the Supervisor has international research reputation in renewable energy integration and so is the best option for this cooperation. The fellowship will significantly contribute to the Researcher's professional development, through outstanding training, public engagement, dissemination of results and 2-way transfer of knowledge with the Host’s research group.

Keywords: photovoltaics pv,power converter and control,power distribution networks,frequency regulation,voltage regulation,reserve and ancillary services,optimization
Design Automation for Quantum Computing (DA QC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria,Germany,Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1979552.0
EU funding (EUR): 1929552.0
Participants: 4
Project status: SIGNED

In the 1970s, researchers started to utilize quantum mechanics to address questions in computer science and information theory— establishing new research directions such as quantum computing. Now, more than four decades later, we are at the dawn of a new "computing age" in which quantum computers indeed will find its way into practical application. However, while impressive accomplishments can be observed in the physical realization of quantum computers, the development of automated tools and methods that provide assistance in the design and realization of applications for those devices is at risk of not being able to keep up with this development anymore—leaving a situation where we might have powerful quantum computers but hardly any proper means to actually use them. This project aims to provide a solution for this upcoming design gap by developing efficient and practical relevant methods for corresponding simulation, synthesis, and verification tasks. While the current state of the art severely suffers from the interdisciplinarity of quantum computing (leading to the consideration of inappropriate models, inconsistent interpretations, or "wrong" problem formulations), this project will build a bridge between the design automation community and the quantum computing community. This will allow to fully exploit the potential of design automation which is hardly utilized in quantum computing yet. Since quantum computers are reaching feasibility, the methods developed within this project will be highly demanded. Preliminary investigations conducted in preparation of this proposal already showed the potential of such an endeavor and raised significant attention in the quantum computing community and its "big players". The project plans to continue these developments on a larger scale—eventually providing the foundation for design automation methods that accomplish for quantum computing what the design automation community realized for classical electronic circuits.

Keywords: design automation,quantum computing,quantum circuit simulation,compilation,synthesis,verification,equivalence checking,decision diagrams,data structures,reasoning engines,search algorithms
Hybrid Entanglement of Light for Interconnected Optical Networks (HELIOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

In quantum information science and technology, two main encodings of information are traditionally used: a ‘discrete-variable’ (DV) approach, based for instance on single photons, and a ‘continuous-variable’ (CV) one, which relies on continuous degrees of freedom such as amplitude and phase of a light field. A mostly unexplored area combines these two different approaches to create ‘optical hybrid schemes’. Recently, entanglement between particle-like and wave-like optical qubits, i.e. CV-DV entanglement, has been generated for the first time by the host group. This resource holds the promise of heterogeneous quantum networks where the two encodings can be combined or interconverted. In this context, the proposed research activities aim at investigating, harnessing, and using the potential of this yet unexplored photonic resource.

Keywords: entanglement,continuous variable,non gaussian states,teleportation
Presynaptic Regulatory Principles in Synaptic Plasticity, Neuronal Network Function, and Behaviour (SYNPRIME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2495593.75
EU funding (EUR): 2495593.75
Participants: 1
Project status: CLOSED

Neuronal signalling via synaptic vesicle (SV) fusion is the fastest membrane fusion event in mammalian cells. Its speed and the ability of presynapses to sustain SV fusion at high stimulation rates are key requirements for brain function. Plastic changes of SV fusion rates have long been thought to control complex brain processes such as working memory, but the link between presynaptic plasticity and complex brain functions remains hypothetical. A key determinant of presynaptic efficacy is that synapses maintain a release-ready or primed SV pool that can be refilled rapidly. SV priming is mediated by a set of dedicated priming proteins (Munc13s, CAPSs, and accessory proteins), which are of pervasive and essential functional importance for synaptic efficacy, and - based on in vitro studies - of capacious potential to regulate exactly the type of synaptic plasticity that is associated with brain circuit characteristics involved in complex behaviours. However, this 'catholic' role of the SV priming machinery in brain function has never been tested, mainly because essential genetic models for studies in vivo have been lacking. Using (i) 4 newly generated conditional KO and KI mouse lines, (ii) 17 additional KOs/KIs (12 ours), (iii) high-end EM approaches (iv) KO-replacement strategies, (v) electrophysiological and optophysiological analyses, and (vi) behavioural studies, we will examine the SV priming machinery in intact circuits in order to (a) define the mechanisms and cell biological basis of SV priming, of its dynamics, and of defined priming-dependent synaptic plasticity states, and to (b) define the causal links between SV priming, synapse function, synaptic plasticity, circuit characteristics, and behaviour. These studies will generate a comprehensive delineation of the role of SV priming in intact neural circuits, which is not only essential for basic science but also for psychiatry, because all key priming proteins are linked to neuropsychiatric diseases.
Re-imagining Environments for Connection and Engagement: Testing Actions for Social Prescribing in Natural Spaces (RECETAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Australia,Ecuador,Finland,France,Czechia,United States,United Kingdom
Call: Innovative actions for improving urban health and wellbeing - addressing environment, climate and socioeconomic factors (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 5403657.5
EU funding (EUR): 5019807.5
Participants: 14
Project status: SIGNED

Re-imagining Environments for Connection and Engagement: Testing Actions for Social Prescribing in Natural Spaces (RECETAS) will address loneliness, a modifiable health condition that is known to shorten one´s lifespan and may be as dangerous to one’s health as smoking or obesity. In Europe alone, and before COVID-19 pandemic, over 75 million European adults reported meeting with family and friends at most once per month and 30 million European adults frequently felt lonely. Loneliness knows no geographic, economic, cultural, and social boundaries and affects all age groups. For urban dwellers, nearby nature, with social structures, can improve health and mental well-being and reduce loneliness. Even under the extraordinary circumstances of COVID-19, people need time in nature for its healing benefits and its role in allowing people to interact in nature. Investments in nature-based solutions (NBS) and green infrastructure (GI) that address rapid urbanization and its adverse consequences on environmental systems in our cities, can be harnessed for health and well-being even in times of health emergencies. RECETAS explores loneliness through a transdisciplinary lens, integrating social, behavioral, health, and natural sciences, and is grounded in participatory principles. It will use randomized controlled trials (RCT) and other epidemiologic, anthropological and health economic methods to test socially- and culturally-innovative nature-based social prescribing (NBSP) in six cities in Europe, Latin America, and Australia. The approach aims to improve upon real-world policy and practice to reduce loneliness by connecting people experiencing loneliness with helping professionals and extensive investments in NBS and GI, while alleviating pressures on stressed health care systems. If successful, it will systematically reduce loneliness, promote and sustain vibrant, socially-connected communities, and reduce health inequalities by connecting to nature in meaningful ways. “RECETAS” is part of the European Cluster on Urban Health.

Keywords: nature based solutions,social prescribing,mental wellbeing,social cohesion,nearby nature