Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic Coupling During Bacterial Development (MetaboDevo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Studies on developmental biology have traditionally focused on deciphering the signaling and regulatory networks that control cellular differentiation. However, it remains unclear how the interplay between developmental regulatory circuits and housekeeping metabolism contributes to the determination of cell fate. Here, I aim to provide a comprehensive analysis of the role of housekeeping metabolic functions during endospore formation in the bacterium Bacillus subtilis. Sporulation is a simple developmental pathway that entails the interaction between two cells arising from a single cell division: the forespore, which becomes the metabolically dormant spore, and the mother cell, which dies after sporulation. The mother cell and forespore activate different genetic programs, leading to the production of sporulation-specific structural proteins necessary for proper spore development. However, little is known about how essential housekeeping functions contribute to the process of sporulation. I have developed a system to degrade proteins catalyzing key metabolic reactions in a cell- and developmental stage-specific manner during sporulation. Here, I will use this system to perform a genome-wide study to evaluate the role that housekeeping metabolism plays in spore development. My preliminary results provide evidence for metabolic differentiation between the mother cell and the forespore, metabolic dependency of the forespore on metabolic precursors synthesized in the mother cell, and bidirectional transport of phospholipids between the mother cell and forespore membranes. I will use a combination of cutting edge genetic, cell biology and chemical biology techniques to reveal the metabolic transactions that underlie this unique, syntrophic relationship. The successful completion of this project will provide the first exhaustive metabolic description of a developmental process.

Keywords: bacillus subtilis,sporulation,metabolism,development
HOUSING DUALIZATION: DIVIDED HOUSING CAREERS AND THE FINANCIALIZATION OF HOUSING MARKETS (HOU-DUAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-23
End date: 2020-04-21
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Recent years have seen a transformation of housing careers. Significant homeownership declines among young adults is evident across Europe, with growing shares in rental or staying on in the parental home. These are not merely symptoms of a temporary recession, but are outcomes of fundamental changes in labour and housing markets alongside shifting state roles. Even in so-called ‘homeowner societies,’ a future of mass homeownership appears unlikely. Rather, we see increasingly divided sectors where insiders have seen sizable asset growth contrasted with significant shares shut out from the housing market. Globally, ‘financialization’ processes have been at forefront of housing market transformation. Financialization describes real forces that have progressively changed the nature of housing, through its integration with global capital flows, neoliberal re/deregulation and increasing commodification: changes that may exacerbate the translation of labour to housing divides. All this, in an era where labour inequalities have increased and housing assets have grown in importance in the face of welfare cutbacks. Given varied homeownership entry, diverging market outcomes, and intergenerational transmission, housing is clearly central to structuring inequalities. Forces of financialization have only amplified the importance of housing towards socio-economic divides. The proposal develops a theoretical and empirical understanding of how European housing is increasingly structured by insider-outsider dynamics - or housing dualization - within contexts of labour inequality and financialization. The quantitative approach is both multi-scalar and interdisciplinary. First addressing macro-level housing divides across national settings, followed by multi-level analyses into individual outcomes structured by differing national and regional contexts. The research builds on distinct literatures across: labour market dualization, comparative housing studies, and financialization.

Keywords: housing inequality,labour market inequality,homeownership,financialization,generation rent,parental co residence,housing systems,welfare systems,intergenerational,intragenerational divides
Bicycle Anti-Lock Brake System (ABS) for Cycling Industry (BikeABS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Hungary
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays more and more efforts are made to make the road traffic safer. Not just for the cars and trucks, but also for the motorbikes. The European Commission passed a legislation in 2012 that made the fitment of ABS for all new motorcycles above 125cc to be mandatory from 1 January 2016. This clearly demonstrates the trend that two wheeled vehicles must follow. The importance of reliable and effective breaking is also important for bicycles and electronic bikes (e-bikes) whose popularity is constantly growing filling the gap between motorcycles and pedal bikes. We are VIDRASOFT a spin-off company of University of Pannonia established in 2002, specialized in automotive electronics, automotive mechatronics and automotive informatics. To reflect this trend in 2 wheeled transport safety we have developed a game changing hydraulic type anti-lock braking system (ABS) for bicycle applications and have protected it with a patent. The functionality of the prototype system has been verified on several real road surface conditions (such as dry and wet asphalt, gravel and dirt roads) in a relevant environment (TRL6). This clearly demonstrates that we are ready for commercialization. Regarding the market size, over 191 Million pedal bikes produced a year world-wide and it is estimated that by 2018 the global e-bike sales will be close to 50 Million. This clearly demonstrates that the market is huge. Based on our pre-feasibility market findings we are initially targeting race and premium segment of pedal bikes as well as e-bikes. According to our initial business projection we estimate at least 3.9 M€ profit in 5 year time after market entry.

Keywords: anti lock braking system,bicycles,security and comfort,safety
DEsign and MOdelling for improved BAttery Safety and Efficiency (DEMOBASE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Italy,Germany,Germany,Germany,Germany,Italy,Sweden,France,France
Call: Multi-level modelling and testing of electric vehicles and their components (H2020-GV-2017, 2017)
Start date: 2017-10-01
End date: 2020-11-30
Duration (months): 38.0
Total project cost (EUR): 7451520.0
EU funding (EUR): 7451520.0
Participants: 11
Project status: CLOSED

Electric mobility is a reality we can experience on our roads and cities. Electromobility is moving forward, driven by drastic cost reductions, higher performances and improved availability to support new business models of autonomous driving passenger cars and new vehicle fleets. DEMOBASE falls within this context with the main objectives to cut down development and testing efforts for e-drivetrains at least by a factor 2 and to improve their efficiency by 20%. Safety will be fully managed and new concepts developed for fleet applications. DEMOBASE is composed of 11 leading European partners with activities ranging from cells to vehicle to recycling. The main gain at vehicle level will come from global optimization taking into account interaction of the different specialties. Objectives at battery level will be achieved by massive digitalization, substituting the today sequential cell development then battery system development by a parallelization of these activities. This new process can be achieved only using enhanced cells models including safety features to define the cell conception for manufacturing and realizing in the same time frame battery management. Objectives at vehicle level will be achieved with a novel approach to design light-weight chassis. It will be demonstrated on a urban demo vehicle that will integrate the advanced battery pack and novels wheel-tire systems with low suspension mass and low rolling resistance. To secure project deliveries and reinforce collaborations which are an innovation key factor, DEMOBASE will be an original closed-loop project. In a first loop of the EV development, building blocks and their integration processes will be investigated and their efficiency assessed using Key Performance Indicators. Then the most efficient bricks and processes will demonstrate their added value in a second step in 6 months run starting from new high performances cells to operational EV. The DEMOBASE EV will be then evaluated on tracks.

Keywords: electric vehicles,drivetrain,battery modelling,ageing,battery cells,battery systems,battery recycling,vehicle chassis,ev wheels,safety and reliability,efficiency
spontaneous Evolution and Clonal heterOgeneity in MoNoclonal Gammopathies: from mechanisms of progression to clinical management (bECOMiNG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1998781.0
EU funding (EUR): 1998781.0
Participants: 1
Project status: SIGNED

As an onco-hematologist with a strong expertise in genomics, I significantly contributed to the understanding of multiple myeloma (MM) heterogeneity and its evolution over time, driven by genotypic and phenotypic features carried by different subpopulations of cells. MM is preceded by prevalent, asymptomatic stages that may evolve with variable frequency, not accurately captured by current clinical prognostic scores. Supported by preliminary data, my hypothesis is that the same heterogeneity is present early on the disease course, and identification of the biological determinants of evolution at this stage will allow better prediction of its evolutionary trajectory, if not its control. In this proposal I will therefore make a sharp change from conventional approaches and move to early stages of MM using unique retrospective sample cohorts and ambitious prospective sampling. To identify clonal MM cells in the elderly before a monoclonal gammopathy can be detected, I will collect bone marrow (BM) from hundreds of hip replacement specimens, and analyze archive peripheral blood samples of thousands of healthy individuals with years of annotated clinical follow-up. This will identify early genomic alterations that are permissive to disease initiation/evolution and may serve as biomarkers for clinical screening. Through innovative, integrated single-cell genotyping and phenotyping of hundreds of asymptomatic MMs, I will functionally dissect heterogeneity and characterize the BM microenvironment to look for determinants of disease progression. Correlation with clinical outcome and mini-invasive serial sampling of circulating cell-free DNA will identify candidate biological markers to better predict evolution. Last, aggressive modelling of candidate early lesions and modifier screens will offer a list of vulnerabilities that could be exploited for rationale therapies. These methodologies will deliver a paradigm for the use of molecularly-driven precision medicine in cancer.

Keywords: cancer evolution,cancer heterogeneity,multiple myeloma,biomarkers
EGNSS-ENABLED SMART ROAD INFRASTRUCTURE USAGE AND MAINTENANCE FOR INCREASED ENERGY EFFICIENCY AND SAFETY ON EUROPEAN ROAD NETWORKS (ESRIUM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Italy,Austria,Austria,Spain,Austria,Hungary,Finland
Call: EGNSS applications fostering green, safe and smart mobility (H2020-SPACE-EGNSS-2020, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 3410893.75
EU funding (EUR): 3000000.0
Participants: 9
Project status: SIGNED

ESRIUM is a multi-national project with the common goal to set up a service to foster greener and smarter road usage, road maintenance, and to increase road safety. The key innovation will be formed by a homogeneous, accurate and recent digital map of road surface damage and road wear. ESRIUM’s core proposition is a data platform, which hosts highly detailed EGNSS-referenced map data of road damage and associated safety risks at centimeter-level resolution. Further addressed as “road wear map”, it will contain unique information, which is of value to multiple stakeholders: road operators will be able to lower the road maintenance effort by optimal planning. Further, road operators will be able to lower road wear and increase traffic safety especially for heavy vehicles. Considering the market introduction of partly automated truck fleets, the precise track of these vehicles can be adjusted by communicating precise routing recommendations in- and cross-lane. Truck fleet operators following these recommendations can receive tolling benefits, and increase the general safety for their vehicle fleet. Especially with the increasing levels of autonomy, systems will utilize infrastructure support to handle the requirements of the automated driving task and additional external requests. In ESRIUM, these opportunities are addressed by utilizing C-ITS infrastructure and EGNSS based localization in planning the trajectories of such automated vehicles. Key to the ESRIUM innovation is a precision localization service, which provides reliable locatization information of road damages and of the vehicles using the roads. Considering a European-level business-case, only Galileo may provide such a service in homogeneous quality, even at very remote locations on the European continent.

Keywords: egnss,road damage sensing,mobile mapping,automated driving
Dream-like simulation abilities for automated cars (Dreams4Cars)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Italy,Germany,Italy,Sweden,United Kingdom,United Kingdom
Call: System abilities, development and pilot installations (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 4302865.0
EU funding (EUR): 4302865.0
Participants: 7
Project status: CLOSED

Dreams4Cars takes inspiration from the Simulation Hypothesis of Cognition – notably in the sense of Hesslow – and in particular from the idea that thoughts are chains of simulated actions and simulated perceptions. The main objective of Dreams4Cars is to set up an offline simulation mechanism in which robots, by recombining aspects of real-world experience, can produce an emulated world, with which they can collectively interact to safely develop and improve their Perception-Action systems, in particular focusing on the analysis of rare events. The Perception Action systems trained by simulations in this way will then be used for sensorimotor control in real interactions. The application domain of Dream4Cars is automated driving, which – besides being a major economic sector for the EU – also poses the issue of developing systems capable of dealing with arbitrary and open-ended circumstances. Accidents are rare events and, to demonstrate that autonomous systems are safe enough (i.e. significantly safer than humans – which is not achieved today at high and full automation levels), extensive field operation tests would normally be required. The solution offered by Dreams4Cars, by focusing on variations of much more frequent near-miss accidents, can develop safe behaviours for hypothetical/unexperienced situations. Hence Dream4Cars will contribute by solving both the problem of discovering critical situations and the problem of updating safely the software. Dreams4Cars will compare the driving agents evolved by the simulation technology to a baseline agent which will have the same State of the Art skills developed by the latest EU project in driving automation (AdaptIVe), hence concretely verifying the added value of the robotic technology (with target TRL 6).

Keywords: simulation theory,subsumption control architecture,action selection,optimal control,perception action hierachy,intelligent transportation systems
PERASPERA (AD ASTRA) Plan European Roadmap and Activities for SPace Exploitation of Robotics and Autonomy (PERASPERA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Spain,Germany,Italy,Poland,France,United Kingdom
Call: Space Robotics Technologies (H2020-COMPET-2014, 2014)
Start date: 2014-10-01
End date: 2019-09-30
Duration (months): 60.0
Total project cost (EUR): 3558166.4
EU funding (EUR): 3437633.0
Participants: 7
Project status: CLOSED

The project “PER ASPERA (ASTRA)” (Latin meaning “Through hardships to the stars”) aims at developing an integrated master plan (a.k.a. roadmap) of activities and associated activity descriptions, for a Strategic Research Cluster (SRC) in Space Robotics Technology. The roadmap will be implemented within a Strategic Research Cluster (SRC) through operational grants, which will be recommended by PERASPERA and issued by the European Commission. PERASPERA will plan and accompany the SRC to attain its overall objective to deliver, within the 2023/2024 framework, key enabling technologies and demonstrate autonomous robotic systems at a significant scale as key elements for on-orbit satellite servicing and planetary exploration. The main deliverables of the PERASPERA project will be: [1] a thoroughly coordinated/harmonised roadmap of space robotics technologies, concept development and demonstration activities. The coordination/harmonisation relies in the pre-existing network of the partners, complemented by new measures implemented by PERASPERA [2] draft text for the calls (and related technical annexes) that will allow tightly coupled developments across different operational grants [3] a Plan for the analysis and evaluation of the results of the SRC, that will be enacted by the PSA across its duration [4] a Plan for the specific exploitation and potential use of the SRC expected outputs that will also consider spin-out [5] a plan for risk assessment and contingency analysis [6] wide-reaching dissemination and outreach actions to communicate to the public and educate the young engineers that will make space robotics become mainstream

Keywords: technology harmonisation,technology roadmapping
CALIPRI - an easily customisable all purpose optical gauge for 2D-profiles. (CALIPRI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Austria
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CALIPRI Smart is a digital all-purpose measuring device for geometrical properties of arbitrary objects. The optical gauge outputs 2D profiles via WLAN and can be used for quality management and safety checks. The most important markets are railway companies and the automotive industry. The key of the innovation is the software of CALIPRI which allows high-precision measurements although the device is hand guided. This software can be adapted easily to the individual needs of the customer. Hence one and the same handheld gauge can be sold as custom-made device, optimized for the applications of the user. The customising is done by a setup assistant software and needs only a minimum of personnel costs. In opposite to devices, which use a hardware developed for a certain niche application, CALIPRI is a universal solution. This allows a high quantity and low unit cost in production. The customisation is the low-cost part of the product and so it is possible to produce niche products at the quantity and price of a mass product. NextSense plans to conquer the international markets with CALIPRI. The competitive price in combination with customised solutions makes an excellent price-performance ratio and provides the opportunity to become the global market leader. NextSense already built up an international distribution network in Europe and Asia. Today most of the customers are railway companies and the automotive industry. In this project, NextSense will find a feasible strategy to conquer the rest of the industrial nations and to enter in new industrial sectors like aerospace, shipyards, household appliance and machine tools. The feasibility study will cover an investment plan, subsidies, HR and marketing efforts. The new organizational company structure and the required financing strategy will be developed. The final result will be a business plan including a schedule of capturing different international regions, an investment plan and a budget plan.

Keywords: laser triangulation,optical gauge,customizing software,railway industry,automotive industry,worldwide commercialisation