Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Artificial Vision Driven Technology to produce High quality and low recoil cartridges (HIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Rossini (Rome’60), Mattarelli (Tokyo’64), Garagnani (Mexico’68), Scalzone (Munich’72), Giovannetti (Moscow’80), Falco and Pera (Atlanta’96), Gudzineviciute (Sydney’2000), Cainero (Beijing’08). All these Olympic champions trusted our products to help them reach the podium, and we are proud to say that Baschieri & Pellagri (B&P), an Italian company founded 131 years ago in the beautiful countryside of Marano di Castenaso (Bologna), has played a role helping different athletes conquer more than 162 gold medals in different shooting championships. B&P is a worldwide recognized premium brand (€35M revenue, 80+ employees) for production and distribution of cartridges, and cartridge components for smooth bore guns, used in shooting competitions and in hunting. Our passion for these sports, our hard work and commitment to continuously research and improve our products, and the international experience gained after 89+ years exporting our products brings us to this very specific moment in time where we still want to challenge the status quo of our business with a new major innovation to our products that makes necessary to rethink our manufacturing process. Thus we came out with HIT – "Artificial Vision Driven Technology to produce High quality & low recoIl cartridges", a strategic action consisting of designing and developing all necessary parts of our new product line, the innovative GS2.0 cartridges, that exhibit further recoil reduction and improved combustion profile, as well as a whole new set of processes and innovative production machinery to support the production of such new line, enhancing substantially production and product safety and quality by means of advanced robotics systems driven by artificial vision recognition techniques. Thanks to HIT, we expect to increase our sales by +15% (due to current unsatisfied demand), reduce costs by a +15% (thanks to bringing cartridge cases production in-house), hence recovering full investment the first year of business.

Keywords: hunting,shooting,sports,firearms,cartridges,precision,safety,quality
PIK3CA-Related Overgrowth Spectrum: molecular mechanisms and preclinical modelling of PIK3CA VARIANTs (PROS-VARIANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

PIK3CA-related overgrowth spectrum (PROS) is a group of rare congenital disorders that manifest as complex syndromes with overgrowth of several tissues (vasculature, adipose and muscle tissues, bones, brain and skin among others) or as localized lesions such as vascular malformations. PROS is caused by somatic activating mutations in the PIK3CA gene that arise postzigotically during embryonic development. Patients suffer dramatic functional and life-threatening complications and typically require extensive mutilating surgery, pulsed laser, and/or sclerotherapy. However, these treatment strategies are insufficient, and patients commonly experience a high risk of recurrence and progression. This is in part a reflection of poor understanding of the underlying cellular and molecular mechanism of their onset and progression. In this proposal, I aim to gain physiological and molecular insight into PROS and address fundamental biological questions concerning when (timing), where (cell linage), who (PIK3CA variant) and how (triggered mechanism) activating PIK3CA variants contribute to the development and severity of PROS. I will address the following key objectives: 1) identify the specific molecular and cellular alterations triggered by strong (H1047R) and weak (E726K) activating PIK3CA variants and 2) characterize their spatiotemporal pathogenesis in PROS using novel mice models. To this end, a combination of in vitro and in vivo approaches, using novel genetically modified mice will be implemented in order to provide new mechanistic insight into the underlying disease pathology and give rise to new preclinical models to test therapeutic treatments. Achieving these goals will strongly contribute to my training as international expert in PI3K signaling, cell biology and congenital diseases, my experimental skillset, and my development towards a well-embedded and independent researcher within European academia.

Keywords: pi3k,endothelial cells,pre clinical animal models
Knowledge and Innovation in, to and from Emerging Markets (K.I.T.F.E.M.)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,Germany,Italy,Germany,Argentina,Italy,China,Denmark,Morocco,Viet Nam,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 900000.0
EU funding (EUR): 720000.0
Participants: 15
Project status: CLOSED

Since the rise of emerging economies in the global scenario, it has been critical to better understand the role of knowledge and innovation played in this process. We focus on researching not only how knowledge and innovation is managed and generated in emerging markets, but also how traditionally they learned from advanced economies to enhance their innovation capability, and recently the reverse innovation process about how this innovation capability in emerging markets affects and is transferred to advanced economies. With this purpose, the proposed KITFEM research project aims to study the management of knowledge and innovation in, to and from emerging markets, with special emphasis on its impacts on the EU. With the proposed secondments among fifteen partners in nine countries around the world in four continents, between partners from academic sector and non-academic sector, KITFEM combines research on the issue of knowledge and innovation between emerging markets and European enterprises, and knowledge sharing and dissemination around the world to enhance the impact of European innovation. Involving 54 researchers, managers, tech, and administrative staff, KITFEM consists of seven work packages to foster the interaction between scientific community and other stakeholders such as institutions, industries, business, and general civil society, to ensure the popular interests and engagement of the researched topic. In such a way, one work package is dedicated to project management and internal communication and another to external communication, dissemination and outreach activities. Five work packages focus on research, training and dissemination, at multiple levels: Institutional-industrial-organizational-individual. With the designed project structure and competitive capability of the fifteen partners involved, KITFEM is expected to generate high impact in the globe, both in term of research excellence and societal engagement.

Keywords: emerging markets,innovation,knowledge,management
Energy CHOices supporting the Energy union and the Set-plan (ECHOES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Austria,Austria,Spain,Türkiye,Bulgaria,Türkiye,Norway,Bulgaria,Finland
Call: Social Sciences and Humanities Support for the Energy Union (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 3999664.25
EU funding (EUR): 3999664.25
Participants: 16
Project status: CLOSED

ECHOES is a multi-disciplinary research project providing policy makers with comprehensive information, data, and policy-ready recommendations about the successful implementation of the Energy Union and SET plan. Individual and collective energy choices and social acceptance of energy transitions are analysed in a multi-disciplinary process including key stakeholders as co-constructors of the knowledge. To account for the rich contexts in which individuals and collectives administer their energy choices, ECHOES utilizes three complementary perspectives: 1) individual decision-making as part of collectives, 2) collectives constituting energy cultures and life-styles, and (3) formal social units such as municipalities and states. To reduce greenhouse gas emissions and create a better Energy Union, system change is required. While technological change is a key component in this change, successful implementation of that change relies on the multi-disciplinary social science knowledge that ECHOES produces. Therefore, three broad technological foci which will run as cross-cutting issues and recurrent themes through ECHOES: smart energy technologies, electric mobility, and buildings. All three technology foci address high impact areas that have been prioritised by national and international policies, and are associated with great potential savings in greenhouse gas emissions. ECHOES’ uniquely comprehensive methodological approach includes a representative multinational survey covering all 28 EU countries plus Norway and Turkey, syntheses of existing data and literature, policy assessments, as well as quantitative experiments, interviews, netnography, focus groups, workshops, site visits and case studies in eight countries. All data collected in the project will be systematised in a built-for-purpose database that will serve both as an analytical tool for the project and as a valuable resource for stakeholders and researchers after the project’s lifetime.

Keywords: set plan policies,individual decision making,energy cultures and lifestyles,formal social units,consumers and prosumers,smart energy technology,electric mobility,buildings
First in the world ecological and sustainable cream for wound care, based on microalgaprasinococcus capsulatus (PrasinoMed)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Skin is the largest organ in human body, providing protective physical barrier for muscles, bones ligaments and internal organs. It is constantly exposed to physical, chemical and biological factors that cause damage by creating wounds. However, the development of new and effective interventions in the wound-care market still remains an area of intense research, as more than 100M people annually suffer from this problem. Modern wound-care products are not providing the necessary level of hydration and due to un-natural substances in the formulation in some cases cause allergic reactions. Prasinotech introduces a novel cream, Prasinomed, for the wound-care market. The cream is based on high quality nongenetically modified, ecologically favourable biological production. Due to formulation from naturally occurring microalgae-prasinococus capsulatus, Prasinomed offers sustainable, antiallergizing and hydrating cream.

Keywords: wound care,microalgae,allergy
Integrating a novel layer of synthetic biology tools in Pseudomonas, inspired by bacterial viruses (BIONICbacteria)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1998750.0
EU funding (EUR): 1998750.0
Participants: 1
Project status: SIGNED

As nature’s first bioengineers, bacteriophages have evolved to modify, adapt and control their bacterial hosts through billions of years of interactions. Indeed, like modern synthetic biologists aspire to do, bacteriophages already evade bacterial silencing of their xenogeneic DNA, subvert host gene expression, and co-opt both the central and peripheral metabolisms of their hosts. Studying these key insights from a molecular systems biology perspective, inspired us to develop these evolutionary fully-adapted phage mechanisms as a next-level layer of synthetic biology tools. Thus, BIONICbacteria will provide conceptual novel synthetic biology tools that allow direct manipulation of specific protein activity, post-translational modifications, RNA stability, and metabolite concentrations. The goal of BIONICbacteria is to pioneer an unconventional way to perform synthetic biology, tapping an unlimited source of novel phage tools genetic circuits and phage modulators. To achieve these goals, we will apply and develop state-of-the-art technologies in molecular microbiology and focus on three principal aims: (1) To exploit new phage-encoded genetic circuits as synthetic biology parts and as intricate biotechnological chassis. (2) To build synthetic phage modulators (SPMs) as novel payloads to directly impact the bacterial metabolism in a targeted manner. (3) To create designer bacteria by integrating SPMs-containing circuits into bacterial strains as proof-of-concepts for applications in industrial fermentations and vaccine design. This proposed “plug-in” approach of evolutionary-adapted synthetic modules, will allow us to domesticate Pseudomonas strains in radically new ways. By building proofs-of-concept for applications in industrial fermentations and vaccine development, we address key problem in these areas with potentially high-gain solutions for society and industry.

Keywords: bacteriophage,pseudomonas,engineering
Real-time renal diagnostic to prevent ICU-acquired Acute Kidney Injury (AKI). (Clarity)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Intensive Care Unit (ICU)-acquired Acute Kidney Injury (AKI) is a prevalent and serious problem, associated with significantly increased morbidity and mortality. According to the Global Burden of Disease (GBD), each year around 1.7 million people worldwide are estimated to die from AKI. AKI develops in over 57% of ICU patients, requiring an average of 3.5 additional hospital days and €13,000 of additional hospital costs per patient. The best treatment for AKI is prevention. Although there is no curative therapy for AKI, research over the past decade identified various means to prevent or limit AKI. Unfortunately, these are not widely known and are variably practiced worldwide resulting in lost opportunities to improve the care and outcomes of patients with AKI. RenalSense introduces Clarity RMS™, a critical care monitoring system that continuously measures urine flow, automatically transmitting to the medical staff real-time data and alerts of fluctuations, on a 24/7 basis. Using patented sensor technology, Clarity measures, analyses and interprets the continuously changing composition and flow volume of urine. This information, which reflects changes in renal function, provides an early sign of AKI risk and facilitates rapid intervention. In addition, it is invaluable for monitoring treatment efficacy and managing fluid balance. The system has been tested during clinical trials with Herzog hospital, Hadassah Medical Organisation and University of Pittsburgh. Analysis of 1,000 study hours showed that electronic measurements with Clarity were more consistent, reliable and accurate than nursing records. During the feasibility assessment, RenalSense will establish a go-to-market strategy, as well as a feasible product development plan and industrialization strategy. The plan for the large-scale clinical trials will be defined, and the participants secured.
Engaged Economists. Politics, profession and economics in the left-wing commitment, 1930s-1960s. (ENGECON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-07-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Abstract: ENGECON will study by a transnational-comparative prosopographical approach the engagement of economists in the communist, socialist and labour lefts over three Western European major countries (France, United Kingdom and Italy), from the 1930s to the 1960s. By engagement, ENGECON means a partisan activism linked to the participation in public debate that contributes to the legitimization, dissemination as well as the elaboration of economic ideas. It studies three principal specific objectives: the factors explaining engagement; the practices of engagement; the implications of engagement for the economic thought, as well as the professional trajectory and the intellectual status of the engaged economists. It assumes that the analysis of engagement is essential to understand the role of economists in society. An unprecedented role of economists in a labour movement on the ascent, the rise of the heterodox economics and the apogee of the managed economy characterise this period. Host organisation: Faculty of History, University of Cambridge.

Keywords: economists,engagement,intellectuals,economics,political parties,militant trajectories,networks
Paleomagnetism and rock-magnetism by Micro-Magnetic Tomography (MIMATOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-07-31
Duration (months): 66.0
Total project cost (EUR): 1785000.0
EU funding (EUR): 1785000.0
Participants: 1
Project status: SIGNED

Our knowledge on the past behavior of the Earth’s magnetic field critically depends on our ability to obtain and interpret magnetic signals from geological materials such as lavas. These materials contain mixtures of different magnetic minerals, some of which are good recorders of the Earth’s magnetic field, others are not. Even the presence of a small amount of minerals with adverse magnetic properties obscures the signal of good recorders, resulting in >80% of measurements of the past Earth’s magnetic field strength being flawed. Understanding the Earth’s magnetic field is pivotal for predicting the future of its shielding capacity against the Sun’s electromagnetically charged particles, which globally weakened by >20% over the last millennium. With MIMATOM, I aim to establish an entirely new way to obtain paleomagnetic and rock-magnetic information from geological materials. I will go beyond measuring magnetizations of bulk samples by determining the magnetic moments of individual minerals embedded in these samples in a non-destructive way. Starting from my recent proof-of-concept of Micro-Magnetic Tomography (MMT), I will develop a radically new technique to assess magnetizations of individual minerals inside geological materials. This will enable understanding which minerals are reliable recorders of the Earth’s magnetic field by characterizing their magnetic behavior as function of their grain size, shape, and chemistry. Then I will use MMT to obtain paleomagnetic information from selections of minerals that I identified as good recorders and unlock information on the past state of the Earth’s magnetic field from even the most challenging and magnetically complex geological materials, such as lavas. My revolutionary new technique will open archives of the past behavior of the Earth’s magnetic field that currently are inaccessible. Moreover, it will pave the way for radically new venues in paleomagnetic and rock-magnetic research, at mineral level.

Keywords: rock magnetism,mineral magnetism,paleointensity,earth s magnetic field,lavas