Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reverse engineering the assembly of the hippocampal scaffold with novel optical and transgenic strategies (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,France
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-07-01
End date: 2027-06-30
Duration (months): 72.0
Total project cost (EUR): 9091074.0
EU funding (EUR): 9091074.0
Participants: 4
Project status: SIGNED

We aim at shedding a unique light on hippocampal function at circuit level through the design of a novel method to trace the construction of brain circuits in health and disease based on hybrid multiphoton in vivo longitudinal color imaging of the dynamics and structure of genetically-tagged neuronal clones from birth into adulthood. This is made possible by the exceptional interdisciplinary collaboration of three labs with expertise in advanced optical microscopy, genetic engineering and systems developmental neuroscience. Our novel methodology, applied here to the hippocampus, will pioneer a new way to track the emergence and plasticity of heterogeneous neuronal circuits as these progressively give rise to function in physiological and pathological contexts, thus bridging the gap between early development and adult circuit physio-pathology. This will enable us to revisit adult hippocampal function from a developmental perspective. The hippocampus is classically described as providing a cognitive map of space, involved in navigation, learning, and episodic memory. However, a more computational and less representational vision of its role presently emerges in which its circuits are best described as producing sequences of neuronal activation arising from the interaction between external contextual inputs and internally-generated preconfigured dynamics. Converging work including ours leads us to hypothesize that internally preconfigured assemblies, shaped by their developmental journey, are the basic modules of hippocampal function. In this context, we will use our new approach to address three interrelated questions: 1) Are assemblies shaped by specific circuits in the adult hippocampus (objective A)? 2) Are they prewired or shaped by experience (objective B)? 3) What is their patho-physiological significance (objective C)? Addressing these major issues raises a timely challenge in both optics and genetic engineering at the core of this synergistic proposal.

Keywords: nonlinear microscopy,multiphoton microscopy,adaptive optics,light sheet microscopy,tissue imaging,harmonic generation microscopy,bioimage informatics,large image data,cell lineage,clonal analysis,connectomics,neurodevelopement,brainbow,genetic engineering,calcium imaging,hippocampus,development,circuits,neuronal dynamics
seCUre and pRivate hEalth data eXchange (CUREX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Cyprus,Greece,Sweden,Belgium,Greece,Greece,France,Netherlands,United Kingdom,United Kingdom,Luxembourg
Call: Toolkit for assessing and reducing cyber risks in hospitals and care centres to protect privacy/data/infrastructures (H2020-SC1-FA-DTS-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-03-31
Duration (months): 40.0
Total project cost (EUR): 4987825.0
EU funding (EUR): 4987825.0
Participants: 18
Project status: CLOSED

The Health sector’s increasing dependence on digital information and communication infrastructures renders it vulnerable to threats to privacy and cybersecurity, especially as the theft of health data has become particularly lucrative for cyber criminals. At the same time, a breach of integrity of health data can have dramatic consequences for the patients affected. CUREX addresses comprehensively the protection of the confidentiality and integrity of health data by producing a novel, flexible and scalable situational awareness-oriented platform. It allows a healthcare provider to assess the realistic cybersecurity and privacy risks they are exposed to and suggest mathematically optimal strategies for addressing these risks with safeguards tailored specifically for each business case and application. CUREX is fully GDPR compliant by design. At its core, a decentralised architecture enhanced with a private blockchain infrastructure ensures the integrity of the risk assessment process and of all data transactions that occur between the diverse range of stakeholders involved. Crucially, CUREX expands beyond technical measures and places emphasis also on improving cyber hygiene through training and raising awareness activities for a healthcare institution’s personnel. Its validation focuses on the highly challenging condition of (cross-border) health data exchange, spanning patient cross-border mobility, remote healthcare, and data exchange for research. CUREX consortium will also utilise the outcomes of the well-known MyHealthMyData project in a dedicated demonstration that will use their blockchain-enabled platform which will control the actual data exchange. We envisage that CUREX will impact the European market developing one of the first blockchain platform for risk assessment management under the GDPR.
L-form bacteria, biotechnology and disease (ELFBAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-06-30
Duration (months): 69.0
Total project cost (EUR): 2428621.0
EU funding (EUR): 2428621.0
Participants: 1
Project status: CLOSED

Despite the clear importance and multiple functions of the bacterial cell wall, many bacteria appear to be able to switch into a cell wall deficient or “L-form” state. L-forms are very heterogeneous in size and shape and generally require osmotic stabilisers, such as 0.5 M sucrose, for viability. However, by lacking the requirement for a cell wall, L-forms are completely resistant to common cell wall antibiotics, such as β-lactams, and they are probably protected from some elements of innate immune recognition. L-forms are therefore of potential interest in relation to their possible involvement in human disease. They have often been reported in clinical specimens obtained from patients with recurrent or persistent infections or on long term prophylaxis with β-lactam antibiotics. Unfortunately, until recently, most of the work on L-forms had been done in the pre-molecular era, when it was difficult to characterise the L-forms and particularly to identify their origins and relationship with other resident pathogenic bacteria. Recently, several labs have revisited the L-form issue and started to apply modern molecular and cell biological methods. The proposal is divided into three Themes: • Improve our understanding of key features of the L-forms of our best characterised model system, B. subtilis, including both basic science and possible biotechnological applications. • Extend our analysis of basic L-form biology into several diverse bacterial systems, of relevance to both biotechnology and infectious disease. • Explore in detail the possible clinical relevance of L-forms, aiming to identify specific clinical situations in which they are relevant or, at least, to establish model systems in which the interactions between L-form and mammalian systems can be studied.

Keywords: l forms,membrane synthesis,infectious disease,bacterial cell wall,bacterial cell division,bacterial cell biology
COHESIVE BANDAGES BASED ON NATURAL FIBRES, WITH ANTIMICROBIAL AND HYDROPHOBIC PROPERTIES BY MLSE TECHNOLOGY (VENDA NATU-haft)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cohesive support bandages are a kind of bandages that are used by professionals of the health sector, for fixing dressings and immobilization splints. Carrying bandages for a long period can cause several inconveniences in patients. Thus, the possibility of conferring them with antimicrobial and hydrophobic properties, without loosing breathability, has become of great interest for the company Calvo Izquierdo S.L., a family-owned company that has positioned at the Spanish market for the development and production of this range of products. However, currently bandages with the said properties can only be produced by using synthetic fibres, which results in a different feel to touch, reducing patient/user comfort and welfare. The Multiple Laser Surface Enhancement technology (MLSE), originally developed for the metallurgic and electronic sectors, has proved to produce surface modifications, at nanoscale, of natural fibres such as wool, conferring them hydrophilic/hydrophobic properties. In VENDA NATU-haft project, Calvo Izquierdo aims at implementing the MLSE technology in their manufacturing system to produce antimicrobial and hydrophobic bandages for sanitary use, based on natural fibres. The use of this technology for the deposition of the cohesive/adhesive coating is also considered. This implementation will allow the company to widen their product portfolio, being able to provide their customers with a new grade of cohesive bandages, based in natural fibres, with enhanced properties. To get this objective, some adaptation of the current MLSE system will be required during VENDA NATU-haft project development. Some modifications in Calvo Izquierdo current production line may also be necessary to incorporate this technology. Phase 1 of VENDA NATU-haft aims to ensure the viability of the project. A technical analysis on the viability of producing natural fibre-based, functional cohesive bandages by MLSE technology will be made and a business plan will be developed.

Keywords: cohesive bandage,functional,antibacterial,hydrophobic,natural fibre,mlse
Enhanced Human Robot cooperation in Cabin Assembly tasks (EURECA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Italy,Italy
Call: Development of System Components for automated Cabin and Cargo Installation (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 1402998.75
EU funding (EUR): 1242386.0
Participants: 4
Project status: CLOSED

The EURECA project framework is dedicated to innovate the assembly of aircraft interiors using advanced human-robot collaborative solutions. A pool of devices/frameworks will be deployed for teaming up with human operators in a human-centered assistive environment, always ensuring safety requirements. Solutions are peculiarly designed for addressing both the working conditions and the management of the cabin-cargo installation process. EURECA aims at providing the following technologies: 1. Lightweight Mobile Arm (LMA), an actuated moble platform equipped by a lightweight manipulator, will assist the assembly of light components. The LMA will perform autonomous tasks for assembly light and small components and it will cooperate with humans in handling and assemblying large, light and flexible compoents, navigating autonomously in the cabin and supplying the different parts by a passive trolley (transporter). 2. Wearable upper arms exoskeleton will be used to assist the human operator in handling and assembling of heavy parts. The exoskeleton will improve the human ergonomics in handling heavy objects, allowing the execution of tasks where two or more people are necessary having a fast attach/detach interface. 3. Continuous update and adaptation of a map of the aircraft’s cabin, including permanent/temporary obstacles (seats, exoskeleton structure, human operator moving, etc.) by RGB-D camera sensors mounted on the LMA. 4. A software platform, called Application Assistant, will enhance human-robot cooperation in all process phases, supporting the generation of programs and the issuing of commands/requests by the users. The Application Assistant will be a layered architecture that will provide the users with different services in creating, scheduling and executing applications. The Application Assistant will implement multi-modular interfaces to humans, as a projector beam to give feedback to the user about the operation status and the actions to be taken.

Keywords: safe human robot interaction,autonomous assembly,mobile manipulation,augmented reality,exoskeleton for empowering workers,erognomics
Archiving and Preservation for Research Environments (ARCHIVER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Pre-Commercial Procurement
Countries involved: Germany,Germany,Spain,Spain,Italy,Belgium,Switzerland,United Kingdom
Call: Pre-Commercial Procurement open (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 4886575.25
EU funding (EUR): 4397917.73
Participants: 9
Project status: CLOSED

Data has both a value and a cost and modern research data management makes many promises in terms of capacity, scalability, ease-of-use and security. The stewardship of research data involves not only all data-related tasks during the active lifetime of a project itself but also preparing the data and associated information for later re-use. The period during which research data remains valuable can stretch into decades. Currently, many research projects cannot manage their data, as the archiving and preservation services are inadequate and fall below expectations while data stewardship costs are frequently underestimated during the planning phase. Using the PCP instrument and building on results of recent projects, ARCHIVER’s goal is to fulfil these data management promises in a multi-disciplinary environment, allowing each research group to retain ownership of their data whilst leveraging best practices, standards and economies of scale. ARCHIVER will combine multiple ICT technologies, including extreme data-scaling, network connectivity, service inter-operability and business models, in a hybrid cloud environment to deliver end-to-end archival and preservation services that cover the full research lifecycle. The use-cases driving the consortium’s need for research and development of innovative data preservation services will extend the preservation ecosystems of the procurers to create more dynamic solutions using a hybrid model combining on-premise capacity with external services operated by commercial suppliers that will be enhanced to comply with the OAIS (ISO 14721) series of standards. One of the main benefits of such a hybrid approach is that it can be implemented in a way that is transparent to data producers and (re-)users. This transparency will address issues that cross discipline and national boundaries, such as findability and interoperability of datasets, as well as reduce costs. The potential uptake for the services resulting from this proposal are many-fold, including supporting the needs of ESFRI and related research infrastructures as well as the results of short-term research projects funded at the regional, national and European-level. The European Open Science Cloud is a major European undertaking that will provide this project with a privileged engagement channel with Europe’s research communities who seek reliable and scalable solutions that satisfy the obligations of data management plans required by funding agencies.
FLOw control in RAdial compressor (FLORA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France
Call: Numerical and experimental study of high speed radial flow compressors (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-09-01
End date: 2023-10-31
Duration (months): 62.0
Total project cost (EUR): 449750.0
EU funding (EUR): 449750.0
Participants: 3
Project status: SIGNED

The enhancement of an engine operability involves increasing the compressor surge margin which is still an open challenge. The project FLORA (FLOw control in RAdial compressor) is twofold. First, it proposes to achieve a comprehensive understanding of the transient behavior of the radial compressor delivered by the Topic Leader through a precise characterization of the instabilities which develop at various rotation speeds and at different IGV (Inlet Guide Vanes) stagger angles. Detailed experimental investigations are planned providing an improved and time-resolved description of the path to surge. Then, it proposes to apply passive flow control strategies in order to push back the compressor surge line towards low mass flow which will consequently enhance the compressor stability, hence the engine operability. The proposal particularly aims at evaluating the benefits from the boundary layer aspiration in radial geometries in terms of performance (gain in pressure ratio and efficiency) and surge margin. Besides experiments, calculations will help for the understanding of the internal flow structures which develop from stable operating points up to surge. High-fidelity Large Eddy Simulations (LES) will be used to get an in-depth comprehension of the impact of the flow control on the internal flow. The project FLORA will contribute to the development of stable and efficient radial compressors with extended operating range.

Keywords: performance map,instabilities,flow control,radial compressor,inlet guide vanes,experiments,simulations
SCIENTIA-FELLOWS II: International Postdoctoral Fellowship Programme (SCIENTIA-FELLOWS II)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Norway
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2019-05-01
End date: 2024-12-31
Duration (months): 68.0
Total project cost (EUR): 17700000.0
EU funding (EUR): 8850000.0
Participants: 1
Project status: SIGNED

The SCIENTIA-FELLOWS II (SF-II) proposal is based on of the FP7-funded SCIENTIA-FELLOWS programme (http://www.med.uio.no/english/research/scientia-fellows/) coordinated by the University of Oslo. The original programme has recruited over 80 researchers and provided excellent training in both research and transferable skills. SCIENTIA-FELLOWS developed into a highly successful programme in Health Sciences that attracted talented researchers from the whole world. UiO will take the programme to the next level, into a broader European context. SF-II will introduce new aspects such as a strong innovation component, new industry and academic partners (including from the Less Represented Countries), inter-sectoral opportunities and new training features in both research and transferable skills. These novel aspects, with diversified training options and exposure to cross-sectoral cooperation will further enhance the experienced researchers’ career prospects and prepare them for leadership positions in research, where scientific and transferable skills are improved with a strong insight into the importance of ethics and gender balance. The new programme will also benefit from the vast experience of the previous edition and from a review performed by independent experts. New SCIENTIA-FELLOWS II will meet the challenges presented in Horizon 2020 and develop into a European knowledge and innovation hub for the benefit of academic and industrial researchers. Through the SF-II researchers will also benefit from the influx of public and private funding available to develop and establish early stage companies in the European context. Through SF-II, the programme partners will establish a symbiotic environment where training, research excellence and innovation will contribute to fueling European economic growth and development of a new generation of researchers and research leaders with experience both in academia and industry cultures to broadly support European excellence.

Keywords: international fellowships,academia and industry,cross sectoral mobility,research excellence,merit based transparent evaluation,diversified training options,leadership course,mentoring,innovation