Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Temporal reconstruction of tRNA abundance during cortical development in progenitor cells (TRANSITION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

The cerebral cortex with its range of specialized excitatory projection neurons is essential to the high-order cognitive functions of the brain. These hundreds of subtypes of projection neurons arise from a uniform pool of multipotent apical progenitors (APs) which sequentially generate neuronal progeny with distinct fates over time. Recent technological advances in single cell transcriptomics revealed the existence transcriptional programs that seed neuronal diversity. While this working model provides a good explanation for the developmental origin of the distinct neuronal subtypes, it is flawed by the existence of some non-correlating mRNAs and proteins. Indeed, a significant fraction of mRNA that characterizes mature neurons can already be found untranslated in progenitors. The additional mechanisms that coordinate the protein synthesis and ensure correct protein expression in progenitors and daughter neurons have not been identified yet. This project focuses on solving the timely question of which mechanisms, synergically with transcription, are required to refine gene expression during neurodevelopment and cortical patterning. To do so, we explore the role of translation and its critical adaptor molecule, the transfer RNA (tRNA), in regulating the competency of APs to generate distinct neuronal fate during mouse embryonic cortices development. We will generate a comprehensive view of tRNAs abundance and translation efficiency in APs at ages E12 to E17. This will uncover a novel regulatory role for tRNAs, updating the conventional view of them as housekeeping genes, and find new candidate genes for cortical development in both health and disease. All in all, we will provide a new working model for how neuronal fate and diversity are regulated and opens avenues for future research in other developmental fields where translation has been previously overlooked.

Keywords: trna,cortical development,translation,apical progenitors,neuronal diversity
Signature of sediment CAscades following Landslides triggered by Extreme Events in the Stratigraphy (SCALEES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,New Zealand
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 272536.32
EU funding (EUR): 272536.32
Participants: 2
Project status: SIGNED

Catastrophic sediment release in fluvial systems is largely driven by landsliding that occurs naturally during extreme events such as earthquakes or storms in mountain belts. Sediments cascade through the river system until they are stored either permanently in alluvial fans and lakes or temporarily in terraces. To mitigate future landslide hazards, it is urgent to better understand past extreme events such as their amplitude and frequencies, which calls for an improved identification of a landslide signal in the stratigraphy. The SCALEES (Signature of sediment CAscades following Landslides triggered by Extreme Events in the Stratigraphy) project aims to provide a calibrated and validated numerical model of multi-grain size sediment transport and storage that will be apply to unravel the signal of landslides preserved in lakes or alluvial fans and in terraces. To do so, this numerical model that is a recent development of the established RIVER.lab landscape evolution model will be parametrised using extensive and unique data collected in New Zealand where co-seismic landslides have heavily impacted landscapes. The combination of empirical data with numerical simulations will allow us to predict for the first time the full signal (all grain sizes) of sediment cascades preserved in the stratigraphy in response to an extreme event at the scale of a catchment. The project builds up upon the complementary expertise of the fellow in the field of numerical modelling of sediment transport and storage, of the outgoing supervisor in sedimentology related to natural hazards and of the return supervisor in fluvial geomorphology. Through the access to a unique dataset of post-earthquake records as well as scientific networks and the design of a detailed career development plan and a tailored training program, the fellow will be provided with a unique skill set to become an internationally recognised geomorphologist ready to tackle interdisciplinary research questions.

Keywords: landslide,sediment transport,grain size
PRE-CLINICAL ASSESSMENT OF NOVEL GLAUCOMA ANTI-INFLAMMATORY RELEASE (PANGAR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Failure in glaucoma drainage surgeries can be >40% at 12 months post-op due to inflammation and fibrosis. These issues are compounded by poor patient compliance in anti-inflammatory drops as well as the logistical challenges of repeat check-ups. These problems are major contributing factors to the $380M direct cost of surgical failure and the broader €2.4B annual economic burden due to glaucoma vision loss. LEP Biomedical has developed "HyaGuard™", an easy to use, proprietary companion product to glaucoma drainage surgeries both new and old. Consisting of a 3D printed drug-loaded mesh surrounded by an outer hydrogel, HyaGuard™ is rapidly inserted into the sub-conjunctival space as part of a standard glaucoma surgery. The drug loaded mesh delivers anti-inflammatory drugs in a controlled manner that matches the inflammatory cascade, thus eliminating the need for self-administered drops. In parallel, the soft outer gel presents a smooth surface for patient comfort and serves to enhance drug-release kinetics. As such, HyaGuard™ offers benefit to both the patient and surgeon through guaranteed patient compliance, improve surgical success rates and enhanced patient quality of life. LEP Biomedical is now focused on full pre-clinical testing and GMP manufacture of HyaGuard™ to advance to first in human studies. Specifically, the PANGAR (PRE-CLINICAL ASSESSMENT OF NOVEL GLAUCOMA ANTI-INFLAMMATORY RELEASE) project contained herein aims to expedite this work by proving runway to achieve critical pre-clinical and regulatory milestones. Specifically, PANGAR ensures successful execution of animal model pre-clinical work including engagement with notified bodies and drafting of relevant documents. This includes pre-clinical but also clinical trial design, site selections and applications for first in human and pivotal trials. On successful completion of PANGAR, LEP Biomedical will then positioned to enter clinical stage TRL 8/9.

Keywords: glaucoma,surgery,inflammation,controlled release,3d printing,
N6 - methyladenosine RNA modification in acute coronary syndrome (MAACS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg,Canada
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 3
Project status: CLOSED

The main aim of the MAACS project is to explore if specific changes in epitranscriptomic landscape of peripheral blood mononuclear cells (PBMCs), particularly N6-methyladenosine (m6A) RNA modification, could be used as a biomarker for acute coronary syndrome (ACS) differential diagnosis and prediction of future adverse outcomes. This project will be the first to (1) identify ACS-specific m6A biosignatures in PBMCs using direct RNA Nanopore sequencing, (2) quantify total m6A RNA modifications in PBMCs of ACS and stable angina patients using LC/MS, (3) assess the clinical utility of total m6A RNA modification in PBMCs, and (4) perform an in vitro functional analysis of ACS-specific m6A modifications. The realization of set objectives will reveal novel mechanisms implicated in the aggravation of ACS that could lead to the development of novel tools for personalized prevention, diagnosis, and treatment. In order to utilize the power of the integrative and multidisciplinary approach, this project will establish collaboration between Dr. Miron Sopic (MSCA PF applicant) and top-tier institutions: CardioVascular Research Unit-Luxembourg Institute of Health (beneficiary) led by Dr. Yvan Devaux (The project’s supervisor), McGill University in Quebec (associated partner for secondment), and University of Luxembourg (associated partner). Working in the international environment with eminent experts and a productive team of researchers and using state-of-the-art infrastructure and techniques will secure the applicant to become an internationally recognized expert in the epitranscriptomic field and an independent researcher with strong credibility competent to establish and lead his research group. MAACS contributes to sustainable development by complying with several objectives: good health and well-being, quality education, gender equality in research, reduced inequalities, and partnership for the goals.

Keywords: epitranscriptomics rna modifications
BIOcomposites in smart plastic transformation processes to pave the way for the large-scale UPTAKE of sustainable bio-based products (BIO-UPTAKE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Spain,Belgium,France,Sweden,Denmark,Ireland,Portugal
Call: Manufacturing technologies for bio-based materials (Made in Europe Partnership) (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 6495326.25
EU funding (EUR): 6495323.5
Participants: 14
Project status: SIGNED

The general objective of Bio-Uptake project is to ensure a sustainable uptake (increase the use in a 39%) of bioplastic composites through boosting a twin green and digital transformation in the European manufacturing industry. In particular, Bio-Uptake solution will focus scientific and technology efforts on developing flexible manufacturing processes to produce biobased end-products for the construction, medical and packaging sectors based on the combination of intermediate formats made of natural and/or biobased synthetic fibres reinforced with biopolymers, which are easily adaptable to new market demands. The novel approach on which Bio-Uptake project relies is based on modularity or pre-fabrication: a smart combination of intermediate formats (organosheets, tapes and pellets) into a final end-product which allows to overcome the current technical and environmental limitations to meet the demanding requirements of a specific sector/application where a single biobased material doesn?t. Thus, the synergistic potential of composite materials will pave the way for the integration and uptake of bio-based materials in mass customised manufacturing (manufacturing as a service). Three disruptive manufacturing processes (based on conformal technologies) will be developed within Bio-Uptake focused on the plastics manufacturing sector, which is on the centrality of a variety of value chains, and being demonstrated in 3 demo cases (bathroom ceiling cabinet, feet orthosis and garbage container lid). Sustainability criteria will be applied since the design phase to reach circularity by design, obtaining products with more than 75% biobased content and decreasing GHG up to 33%. Bio-Uptake solution does not request large investment in complex equipment too. Bio-Uptake consortium is formed by 13 interdisciplinar and complementary partners (6 industries, 4 RTOs, 1 academia and 2 Other organizations). The overall budget is 5,994,886 Euros.

Keywords: conformal manufacturing technologies,intermediate formats,biobased end products,digitalization,bioplastic composites manufacturing as a service,thermosets,thermoplastics,fibres,circularity
Advanced Flexible Tandem Organic Solar Cell Solution and Vacuum Technology (FTOSC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

I intend to travel to the University of Oxford and the lab of Prof. Moritz Riede and build a second-generation version of indium tin oxide (ITO)-free flexible transparent electrodes (FTEs), which I have designed and built during my PhD studies at the University of Hong Kong in Hong Kong SAR. This will be designed not only to note excellent flexibility but also emphasize (1) excellent electrical and optical properties (i.e. sheet resistance <15 Ω sq.-1 and diffuse transmittance >90 %), (2) extremely smooth surface roughness (i.e. PtV <5 nm), (3) enlarged surface conducting channels, and (4) on-demand surface work function covering p- and n-type semiconducting properties, leading to a higher figure of merit (FoM) compared with industry-standard ITO on a glass substrate. In addition, an intermediate recombination layer (IRL) concept that electrically connects two sub-cells in a tandem cell will be devised by using arbitrary hole and electron transport layers (HTLs and ETLs) to advance consecutive manufacturing processes in a facility system without using the PEDOT:PSS. Once complete, I intend to break the record power conversion efficiency (PCE) of flexible tandem organic solar cells (FTOSCs) consecutively manufactured by solution (>20 %) and dry (>12 %) techniques respectively based on the developed on-demand p- and n-type ITO-free FTEs in this proposal, resulting in higher PCEs compared with the identical rigid tandem cells based on the rigid ITO. In addition, robust mechanical operation of the FTOSCs (>90 % PCE retention) under >36.5 k cycles (one year of use, if used 100 times a day) of repeated bending to a radius of 1.4 mm (e.g. Galaxy Z fold 2) based on the developed FTEs will be achieved under AM 1.5 G illumination standard for approximately 12 hours (time difference between sunrise and sunset). Finally, a large area for portable device scale (6-inch) for the ITO-free FTEs will be demonstrated by exploiting the unique spray coater in the host group.
James Ussher and the Making of Protestant Knowledge in the Early Modern World (PROTKNOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

This action will make a ground-breaking contribution to the history of knowledge in early modern Europe. Where previous studies have focused on Protestant scholars as individual actors, this project will use the case of Archbishop James Ussher to show how a leading Protestant ecclesiastical position underwrote and enabled the creation of knowledge. Based at Trinity College Dublin and supervised by Professor Jane Ohlmeyer, the innovative interdisciplinary project will combine the study of Ussher’s unpublished books and manuscripts with the disciplines of cultural, book, gender, and religious history, art history, the sociology and history of science, and the digital humanities in order to create a novel account of the production of knowledge in early modern Europe. Having reconstructed Ussher’s intellectual networks, it will then show how these made possible new kinds of advanced scholarship in terms of the study of scripts, how Ussher read and used his collection of printed books and manuscripts in his chronological research, and ascertain the role played by assistants and amanuenses in Ussher’s working life. In so doing, the action will reveal the importance of confessional networks rather than the pan-confessional Republic of Letters, how far new scholarly methods depended on ecclesiastical preferment and patronage, how the history of reading must use manuscript notebooks in tandem with the evidence of printed books, and how the ascription of published works to individual authors has long obscured the vital roles played by others in their creation. All told, the action will provide a landmark contribution to the making of knowledge in the period between the Renaissance and the Enlightenment and demonstrate the need for a reconceptualisation of intellectual history and the history of scholarship in this era based on a recognition of the symbiotic relationship between works of erudition and the settings in which they were created.

Keywords: early modern scholarship,early modern biblical scholarship,chronology,palaeography,philology,confessionalisation,church history,cultural history,history of the book,james ussher
OPTImised WInd Supported vEssels (OPTIWISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Netherlands,Greece,France,United Kingdom,Italy,Belgium,Sweden
Call: Innovative on-board energy saving solutions (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 4660337.5
EU funding (EUR): 4660337.0
Participants: 16
Project status: SIGNED

The need to reduce energy consumption and emissions to bring global warming to a halt is unprecedented. Although there are energy saving strategies, most innovations cannot simply be merged in conventional ship design. As the solution for making ships carbon neutral will likely come from the use of several energy sources, a clever energy management becomes a key element in a unified ship system. De-rating of engines combined with sailing at slower speed seems to be a relatively easy way to reduce fuel consumption and GHG emissions and will most likely be used in the industry. However, this does come with reduced transport work per ship and reduced earnings. In our view, most other savings methods can deliver savings up to about 15%, not the substantial savings that are required. OPTIWISE aims at two solutions that when combined go well beyond 30% when the innovations are delivered as proposed in this project: Wind propulsion with a rigorous, holistic optimised ship design, control and operation, including a change in conventional propeller propulsion. Wind propulsion is showing its potential in research and market introductions. The holistic ship design and operation pair well with that. For common ships there is much to be gained, especially with the increased freedom in the aft ship geometry with a shift to electric propulsion. Making best use of wind propulsion also requires a rethink of designs, control and operations. To meet the objectives of this call, generic tool and methodology development are planned for optimization, performance and energy management. New developments will be applied to 3 Demo cases, consisting of a Bulk Carrier, a Tanker and a Passenger Vessel. Verification of the results will be done by testing a rotor sail rig, model tests on two ships and Bridge simulations with crew training. By the end of this project it will be clear how much energy can be save with the latest sail propulsion systems for the three types of vessels investigated

Keywords: wind propulsion,optimisation,design
foundaTion mOdels for Robots that haNdle smAll, soft and Deformable Objects (TORNADO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,Belgium,Czechia,Greece,Italy,Luxembourg,Bulgaria,Netherlands,Cyprus
Call: Novel paradigms and approaches, towards AI-powered robots– step change in functionality (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 7449095.0
EU funding (EUR): 7449095.0
Participants: 14
Project status: SIGNED

TORNADO will develop an innovative, multifunctional and adaptive cloud robotics platform, supporting advanced navigation of an autonomous mobile robot (AMR) within complex, time-varying, real-world, human-populated indoor environments. The TORNADO AMR will be able to manipulate small, soft or deformable objects (SSDs) to an unprecedented degree of success, as well as to naturally interact with humans via hand gestures or verbal conversation, by exploiting the zero-shot generalization abilities of deep neural Foundation Models (FMs) for robotics. The AMR's intelligence will rely on a pool of pretrained cloud-hosted FMs, which shall be further adjusted on-the-fly to the current situation via Out-of-Distribution Detection, Test-Time Adaptation and Few-Shot Adaptation subsystems. These will exploit human feedback if available, but will also support autonomous and dynamic cognitive adaptation. Additionally, the TORNADO system will be able to automatically select and set-up on-the-fly the most suitable combination of FMs and non-neural robotics algorithms during deployment, depending on the current situation. In cases of failure, on-the-fly skill acquisition will be supported via integrated, novel Learning-from-Demonstration methods facilitated by an innovative Augmented Reality (AR) interface and eXplainable AI (XAI) algorithms. The adaptive TORNADO system will allow the robot to perform difficult, non-repetitive manipulation tasks on previously unseen SSDs that may change shape during handling, as well as to flexibly adjust to SSDs of different sizes during operation. Measurement of human trust to interactive robots and human behavioral modeling will aid optimal integration/acceptance of TORNADO into society. Validation will take place at TRL-5 in 3 different industrial Use-Cases: flexible small gears manipulation and deformable ply-sheets handling (gears factory), palliative patient care (hospital) and product quality sampling/waste collection (dairy processing plant).

Keywords: deep learning foundation models knowledge graphs imitation learning learning from demonstration explainable ai cloud robotics adaptivity