Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DemoWind 2 ERA-NET Cofund action - delivering cost reduction in offshore wind (DemoWind 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: ERA-NET Cofund
Partnership: DemoWind 2 (ERA-NET)
Countries involved: Spain,Norway,Norway,Belgium,Netherlands,Denmark,United Kingdom
Call: Supporting Joint Actions on demonstration and validation of innovative energy solutions (H2020-LCE-2015-3, 2015)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 10496552.36
EU funding (EUR): 3463862.18
Participants: 10
Project status: CLOSED

DemoWind 2 proposes to bring together a number of national and transnational organisations with an interest in accelerating cost reduction in offshore wind. It follows on from the first DemoWind initiative that launched in 2014 and, like its predecessor, is focussed on enabling industry, through partnership, to push technologies through TRLs 5-6 to 6-7 in transnationally funded projects. We aim to connect existing and new European offshore wind demonstration opportunities, exchange knowledge and facilitate the acceleration of cost reducing innovative technologies to commercialisation. This action will contribute to European cost reduction targets for offshore wind, economic development of the European offshore wind sector and help to maintain the EU’s internationally leading position in offshore wind. Reducing technology cost is essential to increasing the deployment of offshore wind, making a significant contribution to the EU’s climate change targets, replacing aging fossil burning power plants with affordable energy. The main objectives of the DemoWind 2 project are split into two parts: •Part A is dedicated to activities related to the main co-funded Call (Work Packages 1-5) •Part B is dedicated to additional activities (Work Packages 6-7), which will be aimed at widening the dissemination of technologies supported by DemoWind 2 and at identifying and taking forward further opportunities for the DemoWind 2 partners and others to fund further RD&D activities targeting cost reduction in offshore wind without Commission funding. Initially, these additional activities will involve DemoWind 2 strengthening links with existing OSW industry groups looking at innovation and cost reduction, specifically the OWA Europe programme.

Keywords: offshore wind,cost reduction,decarbonisation,technology acceleration,coordination,collaborative
Cost reduction of new Nearly Zero-Energy Wooden buildings in the Northern Climatic Conditions (NERO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Estonia,Finland,Sweden,Norway,Finland
Call: Cost reduction of new Nearly Zero-Energy buildings (H2020-EE-2016-CSA, 2016)
Start date: 2017-09-01
End date: 2021-02-28
Duration (months): 42.0
Total project cost (EUR): 1802615.0
EU funding (EUR): 1802615.0
Participants: 6
Project status: CLOSED

The project develops and demonstrates nearly Zero Energy Wood Buildings design process and procurement models with reduced cost for large-scale use in the northern climatic conditions and on performance level of nearly zero and beyond. The project promotes large-scale market uptake of the developed nearly Zero Energy Wood Building applicable for construction industry design and procurement process. On site and nearby renewable energy system solutions are studied in order to provide real addition of renewable and energy production of on-site energy system. In addition to the nearly zero energy performance level, the project is also focusing on the performance level, which does beyond the nZEB level. Demonstration tasks on net-zero and energy-plus level will be also executed in the project. Analysis of the technical solutions including renewable energy systems will also reach to the plus-energy level because several nZEB buildings studied in the project will be plus-energy buildings. The project develops and demonstrates methods and solutions, which significantly reduce the cost of new nearly Zero Energy Wood Buildings compared to the current situation. The project develops standard design process and procurement models for cost reduction for different building types for the Northern Europe climatic conditions. The cost reduction of the nearly Zero Energy Wood Buildings is shown in the project by means of the demonstration projects including both residential and non-residential single buildings. Wood buildings can result in 50 % reduced GHG emissions compared to conventional buildings with steel and concrete structures.

Keywords: nearly zero energy wooden buildings,renewable energy system solutions,nzeb procurement and demonstration projects,nzeb lifecycle analysis,carbon footprint
Intracellular Action of DNA-based Nano-materials (InActioN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499755.0
EU funding (EUR): 1499755.0
Participants: 1
Project status: SIGNED

Self-organization of matter into structured architectures with emerging functionality is arguably the most important phenomenon to enable life. Unfortunately, human efforts to successfully engineer materials that control hierarchical order and achieve precise action in cells, have suffered from structural heterogeneity and limitations in functional precision. Immune pathways are prime examples of cascades where a finely balanced sequence of interactions decides between life-changing outcomes, varying from tolerance to active fight. Immune-modulating materials, therefore, would uniquely benefit from precision control over functionality. DNA-based nanomaterials have the potential to change our current bioengineering standards due to their inherent architectural uniformity and nanometer control of functionalization, allowing for a quantitative analysis of material parameters on cell activation. The goal of this ERC proposal is to use structural geometry of DNA-based materials to provoke controlled intracellular manipulation of immune signaling via the hierarchical and spatial organization of constitutive DNA binding proteins. We create a circular paradox where DNA defines protein synthesis, yet protein function is controlled by self-organization following interaction with designer DNA. Our approach stands out in its controlled-by-nature strategy: 1) we exclusively use materials derived from cellular building blocks; that 2) respond to stimuli generated without artificial intervention, 3) that we quantify using pathway specific activation markers and 4) image via label-free microscopy to track inherent structural changes in physical material properties. We apply our approach on two important signaling pathways involved in immunology: TLR9 as Th1 trigger for vaccine adjuvants and innate cGAS inhibition to fight autoimmunity. Using spatial organization as foundation for geometry-based immune-engineering will revolutionize the design of novel immune-modulating materials.

Keywords: dna nanotechnology,cell uptake,structural stability,intracellular fate,macromolecule assembly,immune activation
Understanding DNA interstrand crosslink repair – the Fanconi anemia pathway and beyond (XlinkRepair)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

DNA interstrand crosslinks (ICLs) are toxic DNA lesions that are induced by cancer chemotherapeutics but are also formed endogenously. ICL repair is mostly linked to DNA replication, which complicated the biochemical dissection of this process. The classical ICL repair pathway is the Fanconi anemia pathway, affected in the cancer predisposition syndrome Fanconi anemia (FA). Although the repair mechanism is poorly understood, recent studies have revealed unanticipated insights that now allow us to address key questions. While the FA pathway was long thought to be the only replication-coupled ICL repair pathway, two novel pathways were recently discovered. We described one novel pathway that repairs endogenous ICLs induced by acetaldehyde, a product of alcohol metabolism. However, mechanistic details of this novel pathway are lacking. Other unexplored aspects are the role of the chromatin context and the mutagenic consequences of repair. Here, I will capitalize on my group’s expertise applying a unique biochemical system that recapitulates ICL repair, and combine this with newly developed tools to address these objectives: 1) We will decipher key steps in the FA pathway of ICL repair. We will resolve the roles(s) of the FA core complex and the direct function of FANCI-FANCD2 ubiquitination, a key activating step. 2) We will move into new directions and investigate FA-independent ICL repair pathways. We will determine the molecular mechanism of acetaldehyde ICL repair and investigate the repair mechanisms of other aldehyde-induced ICLs. 3) We will extend our knowledge beyond the direct repair factors by defining chromatin dynamics during ICL repair and determining its role. In addition, we will delineate the mutagenicity of ICL repair to evaluate its consequences. These studies will provide important novel insights into how cells maintain genome integrity, increase our understanding of Fanconi anemia, and may improve strategies in chemotherapeutic treatment.
Accounting Technologies for Anti-Rival Coordination and Allocation (ATARCA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Finland,Switzerland
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 2758145.0
EU funding (EUR): 2758145.0
Participants: 7
Project status: SIGNED

Data markets and markets for other digital goods are failing. At the same time, Distributed Ledger Technology (DLT) has been suggested as a means to create new value and new economic structures. However, the underlying economic phenomena, especially the structural characteristics of the digital goods, are poorly understood. For over half a century, economists have made a distinction between rival and nonrival goods. Rival goods lose value when consumed, while nonrival ones may be used repeatedly, without losing value. In Ostrom's terms, the value of rival goods gets subtracted upon use; their subtractability is positive. But there has been increasing indications that many information and digital goods are anti-rival in nature. Anti-rival goods gain value when used; their subtractability is negative. Therefore their economics is also fundamentally different from that of other goods. Most importantly, creating a market price — or, more precisely, open market valuation — for them requires, beyond open markets, additional regulative or technological constructions, such as IPR or DRM, in addition to the market mechanisms. We believe that this structural disparity is a root cause for the market failures in the digital goods and data markets, behind the advent of social media monopolies, poorly working or nonexistent markets for industrial data, and many existing data markets (such as municipal ones) reducing to effectively near-zero price. In ATARCA, we create cryptographically protected anti-rival tokens and test their applicability to governing industrial data markets and fostering cooperation in community driven currencies. If successful, this technology will not only help to properly organise the markets for data and other digital goods, but provide the structural fundamentals of a new type of economic growth. This will allow the societies at large to more widely explore structurally new incentives for systemic sustainability and scalable systemic intelligence.

Keywords: anti rival,network effects,token economy,token engineering,mechanism design,game theory,social allocative welfare,data unions,decentralisation,community currencies
Characterization and HARmonization for Industrial Standardisation of advanced MAterials (CHARISMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Germany,Spain,Belgium,Greece,Bulgaria,France,Denmark,United Kingdom
Call: Towards harmonised characterisation protocols in NMBP (RIA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 4985406.25
EU funding (EUR): 4985406.25
Participants: 14
Project status: SIGNED

In CHARISMA we propose new concepts to harmonise Raman characterisation of materials, developing hardware and reference master samples; algorithms and protocols for spectra acquisition and computational quantitative analysis; and correlations between Raman data and process or product descriptors. We will support data and models sharing under FAIR principles by defining ontologies for data curation, generating an interoperable Raman dataset valid for Raman systems of different configurations, and developing a web-based platform and API’s (Application Programming Interfaces) adapted to end-users with different levels of expertise and equipment resolution. CHARISMA will enable Raman data sharing across domains and across product life-cycle stages, from product design and manufacturing to performance and end-of-life, including recycling. This will foster the industrial implementation of Raman spectroscopy as real-time, in-line and distributed monitoring and control/decision tool, improving the bussines of existing products/processes due to improved product quality and trust, waste minimization and time and energy saving. Raman harmonisation will also enable the fast development of new business based on Raman-active nanomaterials that face different societal challenges related to energy, security, or safety. We will demonstrate the feasibility of CHARISMA concept in three markets: chemical processes (production of catalysts), authentication and traceability of documents and goods, and food safety monitoring. In the long term, we aim to make Raman spectroscopy a widespread technology used within the Industry Commons concept, pave the way for harmonisation in optical spectroscopy, and contribute to joint NMBP-related characterisation efforts and projects.

Keywords: raman spectroscopy,digital spectral data sharing
Evaluating effects of rumen originated lipopolysaccharide on the pathogenesis of subacute rumen acidosis (LIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2023-12-30
Duration (months): 18.0
Total project cost (EUR): 128604.96
EU funding (EUR): 128604.96
Participants: 1
Project status: SIGNED

Subacute ruminal acidosis (SARA) is a well-recognized digestive disorder of high yielding dairy cows that has a negative impact on both animal health and herd profitability. It is associated with increased ruminal lipopolysaccharide (LPS), and LPS has been reported to participate in the pathogenesis of SARA. LPS from E. coli (LPS-E) has been used to study its effects on the SARA pathogenesis. Our preliminary data showed that LPS-E participates in the pathogenesis of SARA by directly increasing the starch-digesting and lactate-producing ruminal bacteria and the genes involved in the LPS biosynthesis process. However, we do not know if LPS-E would be representative of LPS from ruminal bacteria (LPS-R), and thus we do not know how LPS released from SARA cows participate in the pathogenesis of SARA. Therefore, the objectives of this proposal are to 1) isolate LPS from the rumen bacteria by inducing SARA nutritional model in batch culture (WP1, 2, 5, 6 & 7); 2) and compare the effects of LPS-R with the LPS-E on ruminal fermentation, bacterial community composition (BCC), and function by using 16S rRNA sequencing and RNA sequencing in batch culture to elucidate the roles of LPS on the pathogenesis of SARA (WP1, 3, 4, 5, 6 & 7). We hypothesis that 1) LPS from ruminal bacteria could be collected from culture media through inducing SARA nutritional model in batch culture; 2) LPS-R and LPS-E will have different effects on ruminal fermentation, BCC, and functions, but both of the two LPS sources would stimulate the bacteria and genes involved in starch digestion, lactic acid production, and LPS biosynthesis. We expect that our proposal could 1) fulfill the gap of knowledge of the role of LPS on the SARA pathogenesis; 2) provide the direction for industries to develop the products (e.g. clay) could inactive LPS in the rumen; 3) help European dairy industries save at least 994.4 million euros per year due to lower SARA prevalence.

Keywords: ruminal originated lps,sara,rna sequencing,16s rrna sequencing,in vitro
Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities (THYRAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Italy,Hungary,France,Netherlands,Netherlands,United Kingdom
Call: Understanding common mechanisms of diseases and their relevance in co-morbidities (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 6000001.25
EU funding (EUR): 6000000.0
Participants: 8
Project status: CLOSED

We hypothesize that inappropriate thyroid hormone action in target cells is a common mechanism underlying susceptibility to age-related degenerative diseases and co-morbidities. Although regulation of systemic thyroid status is well understood and underpins treatment of common thyroid disease, it is only in the last decade that the importance of local regulation of thyroid hormone action in tissue development, homeostasis and repair has been identified. During evolution, this complex temporal and cell-specific regulation has been optimized for development and reproductive fitness but NOT for ageing. Humans with their exceptional longevity are thus exposed to a prolonged period of suboptimal local thyroid hormone action. Consistent with this, thyroid status is a continuous variable within the population that is related to fracture risk, muscle mass and cognitive decline. Moreover, in healthy longevity thyroid status is characterized by thyroid stimulating hormone in the upper half of the reference range. In these studies, we will determine how local regulation of thyroid hormone action controls tissue homeostasis and repair, whilst its dysregulation is a common mechanism underlying chronic disease development during ageing. We focus on osteoporosis, osteoarthritis, neurodegeneration and sarcopenia as paradigm age-related, degenerative disorders. Using cutting-edge technology, we will (i) identify thyroid hormone dependent biomarkers for disease susceptibility in bone, cartilage, central nervous system and skeletal muscle, (ii) manipulate cell-specific thyroid hormone action in these tissues and (iii) develop cell-type specific modulators of thyroid hormone action. THYRAGE integrates cross-disciplinary expertise from clinical and basic scientists, endocrinologists, neuroscientists, gerontologists, and industry-based peptide scientists. These studies will identify and validate novel strategies for prevention and treatment of chronic age-related degenerative disease.

Keywords: thyroid,mechanism,co morbidities,osteoporosis,osteoarthritis,dementia,neurological disorders,sarcopenia,longevity
Integra A/S – Service provider of drones for civil use (INAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall innovative project and expected outcome is a service that operates drones on behalf of civil customers in Denmark and Europe. As of today, there are many manufactures of drones and an emerging interest among civilians to use drones for commercial and research purposes. However, due to the extensive set of prevailing regulations and certificates to obtain as well as relevant training to require in order to legally and safely operate the drone, it is very intricately work and often difficult for civilians to do. In other words - the link between the suppliers and users is missing! With more than 25 years of experience in the aviation sector, knowledge of the legislative rules and roles in aviation as an international consultancy firm, Integra A/S has the competences and capacity to successfully operate drones and thus provide the market with the missing link – and solve the problem many civilians have. Introducing this service to the European market, Integra A/S is not only a first mover in an emerging business, but also provides an innovative solution that reduces the cost of collecting data remarkably. Areas where drones can be used: • Insurance: Monitoring of damages. • Local municipalities: Monitoring of gas pipes from leaks. • Firefighting department: fast overview of the fire. • Research: Collection of data, e.g. on climate change. These examples illustrate how drones can be used in new ways as well as reduce cost on existing solutions. The feasibility study will set the foundation for the business plan to be developed during this project. The study will, besides assessing the potential customers and the market of suppliers, develop a financial model as well as estimate the potential income etc. A more thorough description is included in the work package description. The outcome of the feasibility study and business plan is going to be used to determine whether to submit a Phase 2 application for the SME Instrument under Horizon 2020.

Keywords: rpas,service operator