Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DNA, Environment, Mineral Association: Reaction Kinetics (DENMARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Environmental DNA (eDNA) is trace amounts of DNA released by organisms into water and sediments. It has recently attracted a lot of attention as it can be a valuable tool for detecting present and past organisms without the need to directly sample them. However, biotic and abiotic decay has severe effects on DNA survival. The adsorption of DNA to mineral surfaces in sediments as well as saline conditions have been shown to protect DNA molecules and decrease the DNA decay rate. Understanding which minerals and environmental conditions provide the best preservation of adsorbed DNA can thus allow us to: a) target such environments for paleoecological and palaeogenetic studies; b) serve as a quantitative tool for assessing DNA migration, i.e. is the recovered eDNA autochthonous?; and c) significantly advance eDNA extraction and analysis protocols by targeting and extracting eDNA from specific minerals. Currently, we only have a qualitative understanding of the DNA-mineral adsorption/desorption at the bulk level and we have no quantitative insight into the DNA-mineral interactions and solution conditions that enhance DNA survival, nor the combined impact on DNA longevity in natural environments. With DENMARK I will (1) assess DNA-mineral associations and correlate with eDNA preservation state in sediments from terrestrial, freshwater and marine settings. Additionally, for a range of sedimentary minerals and a range of environmentally relevant solution compositions I will: (2) quantify the Gibbs free energy (ΔGbu) and kinetic bond parameters of in vitro DNA-mineral interactions; and (3) examine the nature, fraction and stability of interacting bonds of in vitro DNA-mineral associations at the bulk level. (4) Finally, I will link the sediment data to the in vitro single bond and bulk data to make a conceptual model for addressing the characteristics and longevity of different DNA-mineral systems, and improve eDNA extraction protocols.

Keywords: environmental dna,dna adsorption,minerals,kinetics,nanoscience
Addressing multimorbidity in elderly atrial fibrillation patients through interdisciplinary, tailored, patient-centered care pathways (EHRA - PATHS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Germany,Switzerland,Serbia,Belgium,Sweden,Belgium,Poland,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Healthcare interventions for the management of the elderly multimorbid patient (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 5999776.25
EU funding (EUR): 5999776.25
Participants: 16
Project status: SIGNED

Optimization of atrial fibrillation (AF) disease management is highly needed. The AF prevalence is 7.8% above the age of 65 years and it will further increase as the population ages and predisposing factors become more prevalent. Multimorbidity (93.5%) and polypharmacy (76.5%) are very common in these patients. The mean number of comorbidities is 5.0 in those ≥65 years old. There is a great need to optimize the management of AF patients - and not only the arrhythmia - to reduce the burden on patients, society, healthcare system and the economy. The aim of the EHRA-PATHS project is to create well founded, innovative systematic care pathways to tackle multimorbidity in elderly AF patients. We hypothesize that such a well-structured, interdisciplinary, and patient-tailored care program is feasible throughout all healthcare systems in Europe, and effective to optimize outcomes. There are 5 objectives: 1. Further characterize multimorbidity, polypharmacy and sex differences in AF patients by means of clinical data registries. 2. Perform a European needs assessment study to map current clinical practice and identify unmet needs concerning multimorbid AF patient management. 3. Devise and implement new software-supported interdisciplinary, patient-centred care pathways to detect, manage, and follow-up on multimorbidity and polypharmacy in elderly AF patients with a focus on each patient’s unique profile. 4. A two-part evaluation with an initial base mapping followed by a European cluster randomised controlled trial to evaluate the newly developed holistic care paths with predefined key performance indicators. A cost-utility analysis will be included. 5. Disseminate the insights, care pathways and implementation strategy from this project to patients, physicians, hospitals, other healthcare providers and regulatory authorities. The consortium combines extensive expertise from multiple specialties with the support of ESC and EHRA to impact outcomes of multimorbid AF patients.

Keywords: atrial fibrilatrial fibrillation,multimorbidity,polypharmacy,multidisciplinary,integrated care,cost effectiveness,self management,quality of life,patient empowerment,gender,healthcare system
Enquiring Radical Right Across Nations and Territories (ERRANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Urgent scientific and public questions are arising from the current growth of the populist radical right (PRR) across Europe. First, not much is known about activism and internal functioning of these political organisations, because they have been studied mainly from macro and structural perspectives. A second overlooked element is their strong territorial presence, and their ability to mobilize localism and community attachments, turning them into political consensus. Third, the political growth of PRR is accompanied by unprecedented levels of societal polarization, concerning in particular immigration and gender. ERRANT deals on these three ground-breaking issues, by focusing on two major Western European PRR actors: Lega and Rassemblement National. The research, organized in two qualitative comparative case studies, focuses on two small-medium towns actually dominated by the parties (high electoral scores; institutional power; cultural legitimation). Research goals are i) to shed light on the internal life of the party branches; ii) to reconstruct the dynamics of their local implantation; iii) to analyse the production of socio-political conflicts on immigration and gender. Data collection techniques will be quantitative analysis of electoral and organizational data; analysis of documentary sources; participant observation; in-depth interviews. Through its experimental, yet rigorous research design, ERRANT will singificantly contribute to the development of new, empirically grounded interpretative categories of PRR activism. Basing on an experimental mix of immersion and comparison, this project will also inaugurate a new methodological template for the qualitative research on parties. Finally, the research will generate societal impact, by enhancing awareness and understanding of the growing influence of populist radical right parties across Europe.

Keywords: lega,rassemblement national,activism,local communities,communitarian borders,ethnic,gender and lgbt discriminations
Living in the mountains at the Pleistocene-Holocene boundary. Insights on the use of Alpine territories by the last prehistoric hunter-gatherers. (LiMPH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-16
End date: 2022-11-15
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The LiMPH project aims at understanding how mountain environments were exploited by the last European hunter-gatherers at the Pleistocene-Holocene transition (14,000-8500 cal BP), a period marked by important climatic and environmental changes. Through the adoption of different techno-functional methods applied to stone tool assemblages, the project will investigate the lifeways of these hunter-gatherer groups starting from the evidence of the south-eastern Alps – the richest in Europe – and will try to reconstruct the importance of mountain areas in the framework of the socio-economic structure of these human groups. Some key-assemblages will be analysed with an innovative techno-functional approach combining technological and use-wear analyses with confocal scanning microscopy in order to reconstruct the main activities that were carried out at the sites. By cross-referencing these data with those on raw material circulation, faunal exploitation and site distribution, it will be possible to investigate the mobility, settlement system and social structure of the prehistoric groups that colonized such a changing environment after the Last Glacial Maximum. At a general level the proposed research will provide a wider comparative perspective on the exploitation of mountain environments in Europe and will allow to understand which were the most attractive features of the Alpine palaeo-environments that led the last hunter-gatherer groups to intensively settle most of the European mountain ranges during this time span. Results of the project will be made available both to researchers and the general public through several actions including open-access publications and different outreach activities. Results will also contribute to enhance public awareness of the historic value of the Alpine range and to implement the touristic offer of the region.

Keywords: palaeolithic mesolithic transition,lithic technology,use wear analysis,confocal microoscopy,mountain archaeology,south eastern alps
Distributed and Dynamic Graph Algorithms and Complexity (DisDyn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Sweden,Denmark
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 237788.75
Participants: 2
Project status: CLOSED

This project aims to (i) resolve challenging graph problems in distributed and dynamic settings, with a focus on connectivity problems (such as computing edge connectivity and distances), and (ii) on the way develop a systematic approach to attack problems in these settings, by thoroughly exploring relevant algorithmic and complexity-theoretic landscapes. Tasks include - building a hierarchy of intermediate computational models so that designing algorithms and proving lower bounds can be done in several intermediate steps, - explaining the limits of algorithms by proving conditional lower bounds based on old and new reasonable conjectures, and - connecting techniques in the two settings to generate new insights that are unlikely to emerge from the isolated viewpoint of a single field. The project will take advantage from and contribute to the developments in many young fields in theoretical computer science, such as fine-grained complexity and sublinear algorithms. Resolving one of the connectivity problems will already be a groundbreaking result. However, given the approach, it is likely that one breakthrough will lead to many others.

Keywords: dynamic algorithms,distributed algorithms,graph algorithms,conditional lower bounds
Development of new Competitive and Sustainable Bio-Based Plastics (NEWPACK)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Spain,Spain,Spain,Italy,Sweden,Belgium,Switzerland,Romania,Finland,United Kingdom
Call: Competitive biodegradable, compostable and/or recyclable bio-based plastics for a sustainable end-of-life phase (H2020-BBI-JTI-2017, 2017)
Start date: 2018-06-01
End date: 2021-08-31
Duration (months): 39.0
Total project cost (EUR): 5234340.82
EU funding (EUR): 4197929.94
Participants: 13
Project status: CLOSED

The objective of NEWPACK is to validate in industrial setting the production of at least two new bio-plastics based on PHB- PLA blends with improved sustainability performance, obtained by the addition of natural extracts with antioxidant/antibacterial properties and nanoadditives from cellulose and chitin. A new circular economy value chain will be generated from agro-food wastes that will be exploited for the production of PHB, while designing and validating the process up to pilot scale. Blending of PLA and PHB will be validated at pilot scale to achieve specific final product requirements based on targeted products. New bioplastic properties and functionalities will be achieved through incorporation of nanocellulose or nanochitin additives (to improve typical problems of processability and mechanical properties of PLA-PHB), antioxidant and antimicrobial additives. The ability to extend the functionalities will be validated in real industrial environments. NEWPACK activities are underpinned by the prior experience and results (already validated at TRL 3-4) of the partners in order to achieve advanced TRLs (5-6) for the developed technologies, including PHB production from agro-food waste; co-blending of PHB with PLA; nanocellulose extraction from wheat straw and incorporation into PHB-PLA blends and encapsulation of natural antioxidants/antimicrobials for addition to PHB-PLA. Great emphasis will be on assessing technical and economic feasibility of the processes; demonstrating the biodegradability of solutions; ensuring the compliance to the market and regulatory requirements; LCA evaluation; preparing for future scale-up of the processes to achieve a pre-industrial production and identification of stakeholders perceptions, attitudes and expectations towards bioplastics. The NEWPACK consortium has 12 partners with academic research organizations and small and large industries which cover the whole innovation, production and final use value chain.

Keywords: circular economy,sustainable design,environment,resources,sustainability,technological innovation,bioplastic
Advanced cyber-security simulation platform for preparedness training in Aviation, Naval and Power-grid environments (FORESIGHT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Austria,Germany,Estonia,Cyprus,Greece,Bulgaria,Greece,Greece,Greece,Greece,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Cybersecurity preparedness - cyber range, simulation and economics (H2020-SU-DS-2018, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 7292435.0
EU funding (EUR): 5997018.5
Participants: 25
Project status: SIGNED

The FORESIGHT project aims to develop a federated cyber-range solution to enhance the preparedness of cyber-security professionals at all levels and advance their skills towards preventing, detecting, reacting and mitigating sophisticated cyber-attacks. This is achieved by delivering an ecosystem of networked realistic training and simulation platforms that collaboratively bring unique cyber-security aspects from the aviation, smart grid and naval domains. The proposed platform will extend the capabilities of existing cyber-ranges and will allow the creation of complex cross-domain/hybrid scenarios to be built jointly with the IoT domain. Emphasis is given on the design and implementation of realistic and dynamic scenarios that are based on identified and forecasted trends of cyber-attacks and vulnerabilities extracted from cyber-threat intelligence gathered from the dark web; this will enable cyber-security professionals to rapidly adapt to an evolving threat landscape. The development of advanced risk analysis and econometric models will prove to be valuable in estimating the impact of cyber-risks, selecting the most appropriate and affordable security measures, and minimising the cost and time to recover from cyber-attacks. Innovative training curricula, guiding cyber-security professionals to implement and combine security measures using new technologies and established learning methodologies, will be created and employed for training needs; they will be linked to professional certification programs and be supported by learning platforms. Aside from the development of skills, the project aims at a holistic approach to cyber-threat management with the ultimate goal of cultivating a strong security culture. As such, the project puts considerable emphasis on research and development (i.e. research on cyber-threats, development of novel ideas, etc) as the key to increasing training dynamics and awareness methods for exceeding the rate of evolution of cyber-attackers

Keywords: cyber range,cyber threats,cyber security,cr federation,simulation platforms,econometric models,risk analysis,threat forecasting,certification,dynamic training scenarios,cti gathering,sharing
Innovation services for enhancing SME innovation management capacities in Madrid Region (INNMADRIMASD 3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Spain
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 215795.0
EU funding (EUR): 215795.0
Participants: 8
Project status: CLOSED

“IInnovation services for enhancing SME innovation management capacities in Madrid Region- INNMADRIMASD 3” is a proposal addressing the topic ‘Enhancing SME innovation capacity by providing better innovation support “under Horizon 2020. INNMADRIMASD 3 will provide innovation services to SMEs in Madrid through the Enterprise Europe Network as a suitable structure to provide in depth support services to SMEs in the area of innovation management. Furthermore, beneficiaries of the SME Instrument under Horizon 2020 will be entitled to receive specific targeted support from the Enterprise Europe Network to support coaching assignments addressing specific innovation weaknesses for Madrid based SMEs.

Keywords: innovation management,sme instrument,innovation services
The role of chromosome conformation in DNA double-strand break repair (DSB Architect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

The integrity of eukaryotic genomes is constantly challenged by various endogenous and exogenous insults, whereby DNA double-strand breaks (DSBs) are particularly problematic. DSBs can be repaired by multiple pathways, but only the homologous recombination (HR) pathway ensures error-free repair. HR restores missing information around the lesion based on topological interactions with a homologous region on a distinct DNA molecule. HR-directed repair can function across homologous chromosomes in diploid organisms, but is much more efficient between sister chromatids in replicated chromosomes, indicating an important role of chromosome conformation in repair. Sister chromatids are organized by a dynamic interplay between cohesin-mediated loop extrusion, cohesin-mediated sister linkage, and chromatin-based affinity interactions. How these activities shape sister chromatids to support DNA repair is unclear. The proposed project aims to reveal how sister chromatid conformation governs DSB repair efficiency and pathway choice in human cells and to identify and characterize the key molecular factors regulating chromosome conformation for efficient DSB repair. Understanding how intra- and inter-molecular topological interactions contribute to DNA repair will become possible by using a new chromosome conformation capture technology developed in the hosting lab (sister-chromatid sensitive Hi-C). This technology will be combined with a system for acute DSB induction, automated imaging and genomic profiling of DNA repair factors, and targeted protein degradation of cohesin and its regulators to elucidate topological interactions underlying DSB repair. The proposed project will provide insights into how the core machinery shaping the three-dimensional organization of chromosomes contributes to the maintenance of genome integrity.

Keywords: chromosome conformation,sister chromatids,cohesin,dna damage,dna double strand break repair,homologous recombination