Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Resolution cryo-EM Analysis of Ribosome-associated Functions (CRYOTRANSLATION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-05-01
End date: 2017-04-30
Duration (months): 60.0
Total project cost (EUR): 2995640.0
EU funding (EUR): 2995640.0
Participants: 1
Project status: CLOSED

Translation of the genetically encoded information into polypeptides, protein biosynthesis, is a central function executed by ribosomes in all cells. In the case of membrane protein synthesis, integration into the membrane usually occurs co-translationally and requires a ribosome-associated translocon (SecYEG/Sec61). This highly coordinated process is poorly understood, since high-resolution structural information is lacking. Although single particle cryo-electron microscopy (cryo-EM) has given invaluable structural insights for such dynamic ribosomal complexes, the resolution is so far limited to 5-10 Å for asymmetrical particles. Thus, the mechanistic depth and reliability of interpretation has accordingly been limited. Here, I propose to use single particle cryo-EM at improved, molecular resolution of 3-4 Å to study two fundamental ribosome-associated processes: (i) co-translational integration of polytopic membrane proteins and (ii) recycling of the eukaryotic ribosome. First, we will visualize nascent polytopic membrane proteins inserting into the lipid bilayer via the bacterial ribosome-bound SecYEG translocon. Notably, the translocon will be embedded in a lipid environment provided by so-called nanodiscs. Second, we will visualize in a similar approach membrane protein insertion via the YidC insertase, the main alternative translocon. Third, as a novel research direction, we will determine the structure and function of eukaryotic ribosome recycling complexes involving the ABC-ATPase RLI. The results will allow, together with functional biochemical data, an in-depth molecular structure-function analysis of these fundamental ribosome-associated processes. Moreover, reaching molecular resolution for asymmetrical particles by single particle cryo-EM will lift this technology to a level of analytical power approaching X-ray and NMR methods. ERC funding would allow for this highly challenging research to be conducted in an internationally competitive way in Europe.

Keywords: membrane protein biosynthesis
Role of telomeres and stem cells in ageing (ROOTS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Netherlands
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-05-01
End date: 2017-04-30
Duration (months): 60.0
Total project cost (EUR): 2499999.6
EU funding (EUR): 2499999.6
Participants: 1
Project status: CLOSED

The impact of a globally ageing population cannot be overstated. It is expected that by the year 2025 over a billion individuals will be over 60 years of age. In order to develop strategies aimed to restore and maintain function in ageing individuals, a better understanding of the molecular pathways and biological processes that are involved in ageing and age-related disorders is urgently needed. One of the major mechanisms implicated in the decline of tissue function and ageing is the loss of tissue stem cells. This proposal is aimed at developing a better understanding of two fundamental aspects of stem cell biology: the molecular mechanisms that regulate self-renewal and differentiation and the role of telomere attrition and numerical chromosomal abnormalities in stem cell depletion. For both areas we propose to take advantage of recent improvements in DNA sequencing technology. The first area of interest is the role of sister chromatids in parental (stem) cells on gene expression in daughter cells. For such studies we have developed DNA sequencing techniques that allow identification of specific sister chromatids in single daughter cells using parental DNA template strand sequences. Studies in this area will address an aspect of cell biology that has not been subject to direct experimentation before. For studies on the role of telomere attrition and numerical chromosomal abnormalities in ageing we will use material from humans participating in the LifeLines project in Groningen (160,000 individuals) as well as suitable mouse models. Such studies will employ novel single cell sequencing techniques and telomere length measurements. We are specifically interested to measure telomere dysfunction and aneuploidy in stem cells and more differentiated cells, to identify genetic and other factors regulating human leukocyte telomere length and to study the role of telomere attrition in various leukocytes in relation to normal human ageing and pathology.

Keywords: stem cells,sister chromatids,telomeres,chromosome loss,ageing,pathophysiology.
Quantitative Imaging of Liver Fibrosis and Fibrogenesis (LIVERFIBROSISIMAGING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Germany,Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-08-01
End date: 2017-07-31
Duration (months): 60.0
Total project cost (EUR): 2454603.6
EU funding (EUR): 2454603.6
Participants: 3
Project status: CLOSED

Chronic liver disease can progress to cirrhosis, with death due to liver failure and cancer. Cirrhosis prevalence in the EU is 0.5%-1%. However, development of therapies that prevent progression to cirrhosis is hampered by the lack of a sensitive, non-invasive method to quantify fibrosis or fibrosis progression (fibrogenesis). Liver biopsy 1) is risky, 2) shows high sampling variability, and 3) is too insensitive to assess fibrosis progression in clinical studies. Conventional radiological imaging, serum markers, and ultrasound- or MR-elastography do neither permit exact fibrosis nor any fibrogenesis measurement. We plan to develop a clinically applicable methodology to quantitate fibrosis and fibrogenesis over the whole liver using imaging agents that target and thus quantify abundant fibrillar collagen or key cells that drive fibrogenesis (activated myofibroblasts and cholangiocytes). We demonstrated the feasibility of this approach using radiolabeled conjugates of high affinity that target integrin alphaVbeta6 and PDGFbeta receptor that are cell surface molecules of activated cholangiocytes and myofibroblasts. i.v. injection of the integrin conjugate allowed quantitative imaging of alphaVbeta6 expression and correlated with whole liver fibrogenesis. We intend to optimize nonpeptide and peptide ligands for integrin alphaVbeta6, PDGF beta receptor and fibrillar collagens using novel linkers and oligomerization, using PET-radioimaging with Ga-68, Sc-44 and F-18. The targeted imaging constructs will be validated in vivo using established rodent models with defined liver fibrosis and fibrogenesis, with and without antifibrotic drug therapy. Translation to phase I and II clinical studies is planned in years 4-5 of the project. The technology will for the first time allow for 1. individual risk assessment of fibrosis progression, and 2. rapid testing of antifibrotic drugs and their combinations in small groups of individual patients.

Keywords: liver fibrosis,liver cirrhosis,quantitataive imaging,drug development,therapy monitoring,antifibrotic therapy,individualized medicine
Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity (UB-DECODED)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2367337.0
EU funding (EUR): 2367337.0
Participants: 2
Project status: CLOSED

Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkage types in the native TNF receptor signalling complex (TNF-RSC). Our knowledge of the specific functions of the different ubiquitin linkages is currently very limited. However, their presence in the TNF-RSC, combined with our recent technological advance in dissecting the composition of this protein complex with previously unreached specificity and sensitivity provides a unique opportunity for the proposed research programme: to molecularly and functionally decipher the ubiquitin code. We will aim to achieve this by studying the different ubiquitin chain linkages at the molecular level within the TNF-RSC and by determining how perturbation of specific ubiquitin linkage events impacts the physiological role of TNF in immunity to infection and its pathological function in inflammation-induced cancer. The specific objectives of this project are: • to molecularly decipher the ubiquitin code of the TNF-RSC (objective 1), • to link this code to physiological functions of TNF in immunity to infection (objective 2) • and to test its pathological impact on cancer-related inflammation (objective 3).

Keywords: innate immune signalling tnf ubiquitin nf-kappab map kinases apoptosis necrosis infection listeria monocytogenes inflammation cancer-related inflammation
Thermal Management of High Power Microsystems Using Multiphase Flows (THERMAPOWER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Switzerland,United Kingdom
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-04-02
End date: 2016-04-01
Duration (months): 48.0
Total project cost (EUR): 445200.0
EU funding (EUR): 401100.0
Participants: 3
Project status: CLOSED

Increased functionality and power consumption of microdevices and high power electronics has come at a cost: power dissipation and heating. This heat must be dissipated to ensure reliable operation of such devices in both earthly and reduced gravity environments (eg space industry), without adversely affecting their performance. With a highly competitive world market, worth tens of billions of Euros, it is imperative for EU to gain a competitive position in this field (currently led by USA and China). The proposed work is an important step towards developing novel, efficient and reliable thermal management via phase-change through international collaboration between top research groups in EU, USA and China. These include 12 experienced researchers from University of Edinburgh, Shanghai Jiaotong University, Ecole Polytechnique Fédérale de Lausanne, University of Maryland and University of Nottingham. These partners have complementary expertise in microfabrication, experimental techniques, analytical and numerical modelling. The collaboration enables knowledge transfer and access to unique facilities such as those at NASA, Intel, Hua Wei and IBM, reinforcing the research standing of EU in this crucial technological area. It also offers an opportunity for training 20 early stage researchers in state-of-art experimental and modelling techniques. The collaboration exploits and extends ongoing studies in two-phase flow and heat transfer by the partners. These comprise studies in pool boiling, evaporation, flow boiling and condensation, adapting and optimising these for thermal management of micro/optoelectronics systems. The objective is towards developing an integrated cooling system within electronic microdevices interfaced with an external circuit to take advantage of strengths in high energy efficiencies of phase-change. Potential applications cover devices such as cellphones, refrigeration systems, supercomputing clusters and space equipment.

Keywords: thermal management,heat transfer,boiling,multiphase flows
Distributed Knowledge-Based Energy Saving Networks (DISKNET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary,Greece,Croatia
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 505700.0
EU funding (EUR): 505700.0
Participants: 4
Project status: CLOSED

Project DISKNET, plans an innovative scientific exchange in the field of designing and optimising distributed networks for efficient energy supply, management and use. The sustainability in the development in the EU and worldwide depends on a number of interrelated factors, originating from the environment, the economy and the society. Sufficient and secure energy supply at acceptable cost and minimum environmental impact is key to achieving sustainability regarding all these aspects. The current proposal, addresses all the three aspects– environmental, economic and societal, by proposing research and integrated knowledge management for improved efficiency of energy supply, conversion and utilisation. The objective of the proposed project is to stimulate a long term research collaboration between academic organisations from the European Research Area (ERA) (Hungary, Greece and Croatia) and leading academic partners from third countries (Ukraine, Jordan and Morocco), in the area of energy systems engineering and energy supply chains. This will be achieved by undertaking the following joint activities: • Implement a well structured mobility programme of researchers through two-way exchanges • Organise a series of training courses, seminars and workshops for researchers both ERA and other countries • Evaluation and assessment of tools, methodologies and approaches for the design, operation, control and optimisation of energy supply chains involving distributed energy generation and polygeneration of energy and other products • Organisation and joint participation in conferences • Joint research involving simulation, design and feasibility studies. • Cooperating with governments, energy investors and other research organisations to present the results of the joint support actions • Integrated exchange and management of knowledge using modern information and communication technologies

Keywords: biofuels,biomass,wind energy technology,process engineering,thermal engineering
Secondary photochemical reactions and technologies for active remote sensing of nocturnal atmosphere (NOCTURNAL ATMOSPHERE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Latvia,Germany,Germany
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2013-02-04
End date: 2017-02-03
Duration (months): 48.0
Total project cost (EUR): 239400.0
EU funding (EUR): 239400.0
Participants: 3
Project status: CLOSED

The key objective of the “NOCTURNAL ATMOSPHERE” project is to carry out the coordinated transfer of knowledge measures between participating teams in the EU, in the Ukraine and Russia with the aim of restoring and strengthening scientific collaboration and of developing new partnerships for long lasting synergy, to enhance the level of scientific excellence of participating early stage and experienced researchers and technicians. The transfer of knowledge and achievement of intellectual “critical mass” will occur through performing joint theoretical exercises and laboratory research in the important and growing field of secondary photochemical reactions in the Earth’s nocturnal atmosphere and in development breakthroughs of active remote sensing technologies for night-time cartography of the Earth troposphere and stratosphere. The challenge is to create a unique instrument for ranging sensors on satellite, crossing night-time sky segment, with a combined laser&white light beam from the Earth. The project participants have high scientific qualification and relevant theoretical and experimental experience and specific technical skills to achieve progress in research on the nocturnal atmosphere. The joint efforts will work synergistically to amplify their knowledge and skills. The staff exchange and secondments will include both a team doing research on specific work packages and a transfer of knowledge component consisting of seminars, workshops and summer schools which will ensure effective dissemination of results and foster interactions amongst the young researchers and PhD students. They will be mentored by and intensively exposed to a culture of international collaborative research.
Increase in opportunities for strategic collaboration in the field of nanotechnology via twinning of IOP with institutions of European Research Area (NANOTWINNING)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Ukraine,Estonia,Italy,France,Greece
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-12-01
End date: 2015-03-31
Duration (months): 40.0
Total project cost (EUR): 554211.0
EU funding (EUR): 498696.0
Participants: 5
Project status: CLOSED

The Nanotwinning Project is aimed at one of FP7 Thematic priorities - Nanosciences, Nanotechnologies, Materials & new Production Technologies. The project provides a number of events, which are focused on increasing opportunities for collaboration in the field of nanotechnology via twining of IOP with institutions of ERA. The Institute of Physics of the National Academy of Sciences of Ukraine (IOP) is the coordinator of the Project. European partners of Nanotwinning Project, namely Pierre and Marie Curie University (France), the University of Torino(Italy), the University of Tartu (Estonia) are well recognized in the world in the field of nanotechnology and European Profiles (Greece) will assist in creation of strategic plan of development of the IOP. There are 5 Work packages (WPs) provided in the Nanotwinning Project: the 1st WP is aimed at general coordination, achievement of all project milestones and implementation of the Project. The 2nd WP is an integration of scientists of IOP in ERA by experience exchange, creation of joined Surface enhanced spectroscopy laboratory and holding of “Nanobiophysics” conference. The 3rd WP provides involvement of youth into promising directions of research by open days in the Institute, issuance of short-term grants for training, travel grants for participation in conferences and holding of international summer school “Nanotechnology: a Hands-On Experience with Fundamental Background and ways of raising Finance in the science”. The 4th WP is the search for ways of additional funding attraction into science and innovations – it is planned to hold short-term theme workshops, technological meetings, where not only representatives of science and external experts, but also representatives of business will be involved. On the last stage (WP5) the system of strategic management of IOP will be improved by creation of plan of the Institute sustainability for the next 5 years.

Keywords: twinning,nanotechnology,nanocomposites,collaboration,smes,technology transfer,trainings,networking,young scientists,sustainability policy,joint experiments,good practice exchange,ukraine
Enhancing the capacities of the ELIRI Research Institute in applied research to enable the integration of Moldova in the European Research Area on the basis of scientific excellence (MOLD-NANONET)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Germany,Romania,Moldova, Republic of,Portugal,Israel
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-12-01
End date: 2014-05-31
Duration (months): 30.0
Total project cost (EUR): 532710.0
EU funding (EUR): 474999.7
Participants: 6
Project status: CLOSED

The objective of MOLD-NANONET is to assist the ELIRI Research Institute to develop and implement a research strategy that will expand its activities and increase its level of excellence in micro-nano-electronics related to the development of intelligent systems, so that it can compete and collaborate with leading research institutions in Europe. MOLD-NANONET will create a unified infrastructure in Moldova by integrating the R&D capabilities of the city of BELTI with those of the capital city (Chisinau). Training activities will be opened up and integrate with activities in other relevant research institutions in Moldova and with the new Technological Park affiliated to ELIRI. MOLD-NANONET will stimulate the creation of a bridge between applied research and innovative business. Focus is on a new research and training program for young researchers at ELIRI and BELTI in integrated nanostructure networks for implementation in intelligent systems. This will be realized through: - Combining existing facilities at ELIRI in the field of micro-nano-technology with new equipment to extend the expertise to integrated networks of nanostructures based on magnetic, thermoelectric and shape memory metals for applications in intelligent systems based on synergetic integration of nanoelectronics, fine mechanics, product design and soft development. - Establishment of a training program to integrate the principles of nanoscale science in research and coursework for the development of a new generation of experts at the intersection of nanoelectronics, fine mechanics, product design and soft development. - Training modules to teach Master and PhD students how to promote a new technology, novel material or device to the market via technology transfer based on innovation. - Training modules will assist researchers and staff from across Moldova to attain a practical understanding of FP rules and regulations and receive training to increase success in FP proposals.

Keywords: nanotechnology,micro-nano-technology,technology transfer