Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Uncovering mechanisms and organization underlying selective regulation of mRNA translation (TRANSLATOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

The gene expression pathway includes transcription, mRNA translation, and protein degradation. Altered translation can rapidly modulate protein levels, without requiring changes in transcription, and can therefore efficiently control cellular responses. Despite evidence of key roles for transcript-selective modulation of translation, the extent and organization of translational control at a transcriptome-wide level is largely uncharted. Moreover, major cancer types appear to be under strong post-transcriptional regulation affecting metastasis and prognosis. TRANSLATOME aims to identify the organization and mechanisms underlying transcriptome-wide modulation of translation. First, I will explore and identify modules whose translation is consistently co-regulated across many cellular conditions, and therefore share common mechanisms, using network module identification. Dependencies between activities of translation modules, which are suggested from the preliminary data, will be studied in detail. This part will exploit polysome or ribosome profiling data from public repositories. Second, I will determine the mechanisms underlying translation modules and how their activities are orchestrated. This will be achieved by identifying RNA features driving the coordinated translation of mRNAs within modules, and how these – via encoded proteins – determine activities in key biological pathways. Finally, I will assess whether modules underlie translation patterns or subtypes of breast and glioblastoma tumours. This interdisciplinary approach requires molecular biology, bioinformatics, systems biology, algorithm development and applied statistics. TRANSLATOME will bring new insights into the transcriptome-wide organization of mRNA translation, which is pertinent to complex diseases. Particularly, I expect to elucidate how mRNA translation is altered in breast cancer and glioblastoma, paving the way for treatments aimed at reversing dysregulated translation programs in cancer.

Keywords: mrna translation,untranslated region
Ferry demonstrator for the switch to safe use of sustainable climate neutral fuels in Adriatic - Zero Emission Adriatic Ship - ZEAS (ZEAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Croatia,Germany,Slovenia,Greece,Austria,Spain
Call: Demonstrations to accelerate the switch to safe use of new sustainable climate neutral fuels in waterborne transport (ZEWT Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 18904285.0
EU funding (EUR): 13503786.25
Participants: 15
Project status: SUSPENDED

The main aim of the project is to contribute to accelerating the shift to safe use of sustainable climate neutral fuels in waterborne transport through a full scale on board operational demonstration of a new system powered by hydrogen fuel cells with maritime applications. An international consortium of top-notch entities covering the whole innovation value chain will develop, validate and demonstrate a new zero emission passenger ship powered by hydrogen and the associated hydrogen distribution, storage and bunkering solution. The ship will be specifically designed to operate in the Adriatic Sea, which is known for its pristine environment and sensitive marine ecosystems. The commissioning and validation in the operational environment through sea trials will be performed to ensure compliance with certification authorities. Emissions assessment, environmental performance studies, risk and safety assessments will be performed on the new system. Advanced digital technologies, including digital twin for monitoring, control and simulation and predictive maintenance solution enhanced with augmented reality systems, will also be developed, documented, tested and optimized during the project for ship owners, operators, shipyards and associated engineering firms. Finally, a detailed feasibility assessment and business planning will be developed to establish commercialisation and scalability opportunities. A successful realisation of the project will facilitate the wider adoption of sustainable climate neutral fuels within the European maritime transport sector in line with the Green Deal objectives, contributing to its efficiency, safety, resilience and international competitiveness.

Keywords: hydrogen,adriatic,zero emission,sustainability,innovation,transportation,smart digitalisation
High Energy Laboratory for Magnetised Plasma Studies (HELIOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Japan,Australia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 3
Project status: SIGNED

The HELIOS project focuses on advancing the understanding of high-power, high-density expanding magnetised plasmas, with an emphasis on charged particle dynamics. The primary objective is to develop and experimentally test an innovative high-power radio-frequency plasma source with a magnetic nozzle, which will be used for topics spanning space propulsion technologies, fusion research and fundamental space plasma physics. Through a combination of advanced diagnostic techniques, the project seeks to address both unresolved plasma physics questions and engineering challenges related to high-density magnetised plasmas. A comprehensive experimental campaign will allow the investigation of the high-density plasma behaviour, with a particular focus on ion acceleration, charged-particle transport, and plume instabilities. Advanced diagnostic techniques, such as Laser-Induced Fluorescence, Thomson Scattering and custom-build high-density intrusive diagnostics, will be employed to characterise the plasma. The project will also include a significant data analysis phase, where the gathered experimental results will be interpreted. These results will lay the base for future research in plasma physics (with focus on space weather and fusion research), and spacecraft propulsion. International collaboration is a key component of HELIOS, with secondments at prestigious institutions like the Australian National University and Tohoku University. These collaborations will enable knowledge exchange and provide access to specialized expertise and resources, further enhancing the project’s outcomes. By leveraging this international expertise, the project aims to position Europe at the forefront of research in understanding the plasma behaviour in a magnetic field and its engineering applications. The ultimate goal of the project is to establish a world-class multidisciplinary laboratory environment in the EU that will serve as a hub for future research in experimental plasma physics.

Keywords: high density plasma,ion acceleration,plasma thruster,space weather,magnetic nozzle,fusion energy
Hydrozine Generator for Zero-emission Power on Demand (DENS X4)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-03-01
End date: 2025-08-31
Duration (months): 42.0
Total project cost (EUR): 2973750.0
EU funding (EUR): 2081625.0
Participants: 1
Project status: SIGNED

DENS’s mission is the creation of highly reliable power sources that provide renewable and zero-emission power everywhere. Based on a patented technology we develop and build reformers that provide clean and affordable hydrogen gas (H2) via the conversion of hydrozine (or otherwise known formic acid) - a liquid sustainable hydrogen carrier. With DENS X4 we introduce the world's first commercially available hydrozine stationary power generator, where our proprietary reformer transforms hydrozine into H2 gas and subsequently supplies a fuel cell for electricity generation on demand. It is an excellent replacement of high polluting diesel generators, as zero harmful substances like CO2, NOX, SOX, soot and noise are emitted into the environment. While emissions from the fuel consumption are the building blocks for the hydrozine itself, “making it a 100% renewable fuel”.

Keywords: construction,fuel cells,hydrozine,generators,sustainable power supply,zero carbon,net zero,hydrogen
A new device to analyse the regional variations of mechanical properties in cells and tissues: prototyping and assessment of commercial potential for drug discovery applications (MECHANOMICS-POC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Mechanomics refers to the measurement of mechanical properties at the microscopic scale in biological tissues. Strong hopes are currently placed on mechanomics to evaluate quantitatively how a treatment or a gene expression affects the stiffness or strength of a tissue, with major impacts expected in drug discovery, diagnostics and genomics screening. However, there is a pressing need for new instrumentation technologies in mechanomics. In the BIOLOCHANICS ERC CoG project, we developed and validated a novel multimodal technology addressing these challenges. Our technology can perform the following actions: 1. apply controlled loads on tissue samples, 2. measure the induced bulk deformations at the micron level and 3. map the distribution of local stiffness of these tissues. Our technology shows very competitive potential for mechanomics in general. However, as an innovative technology, it remains now at the stage of a technological concept with a first laboratory application (TRL2-3) achieved within the ERC CoG BIOLOCHANICS project. Our global objective in MECHANOMICS-POC is to reach TRL 6 in order to take it further towards a commercial innovation: make a first integrated prototype, test it in an intended environment, and refine the comparison with existing technologies. Our specific objectives are (O1) to build an integrated user-friendly prototype; (O2) to determine further IPR strategy; (O3) to establish the commercialization strategy including market research, industrial partnerships and lead management; (O4) to validate the prototype in real-world conditions and present it to industrial stakeholders in the identified sectors. Beside the development and assessment of the prototype demonstrator, we will focus on the future exploitation and commercialization roadmap of this technology, which is aimed at becoming a standard laboratory equipment or service for fundamental research in life sciences and for drug discovery applications.
Rethinking EDI Practice and Policy through Evolutionary Psychology (REDI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2026-12-31
Duration (months): 12.0
Total project cost (EUR): 138093.96
EU funding (EUR): 138093.96
Participants: 1
Project status: SIGNED

REDI (Rethinking EDI Practice and Policy through Evolutionary Psychology) aims at revising how International Business (IB) views Equality, Diversity and Inclusion (EDI). EDI has come to be viewed as an essential tool in effective management, and Multinational Enterprises (MNEs) are uniquely placed to rise to the challenge of reducing inequality. Yet to date, interest in EDI within IB has been largely instrumental and mainly limited to pursuing performance gains or reducing losses at a firm level. Essentially, the approach taken to EDI within IB literature employs intricate but ultimately shallow categories of diversity. As a poorly fabricated concept susceptible to almost infinite variations in interpretation, it is hardly remarkable that the literature reports conflicted empirical relationships between diversity and firm outcomes. Consequently, EDI research in IB to date is not able to explain, for example, why resistance occurs within MNEs, nor the potential for management agency. This is a significant omission as top management exerts a pivotal influence on firms’ actions and outcomes especially regarding discretionary social initiatives. Therefore, REDI asks: 1) “How can MNEs create more equal and inclusive EDI practices?” Resolving this question increases conceptual clarity between “equality”, “diversity” and “inclusion”, directs attention towards managerial action, and decreases the need for finding ever more intricate categories of diversity. And 2) “How can policy level changes support more equal and inclusive EDI practices within and beyond the MNE?” Resolving this question increas directs attention to creating a climate where EDI policies can become successful beyond ticking the box. In answering these questions, REDI will draw on evolutionary psychology and the origins of human relations as revealed by archaeological evidence, claiming that the notion of EDI could only emerge because of the existence of artificial boundaries imposed upon human relations.

Keywords: equality,diversity and inclusion mne management policy evolutionary psychology
Brain mechanisms underlying mathematics and its acquisition (MathBrain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2857101.0
EU funding (EUR): 2857101.0
Participants: 1
Project status: SIGNED

Mathematics is a fundamental tool by which we understand the universe, yet its cognitive and brain mechanisms are vastly understudied. I propose a systematic study of the human representation of mathematical concepts and their growth with education. The project will test the “language of thought” theory according to which humans share core concepts with other animals (numbers, objects, shapes, spatial maps) but the growth of math relies on a human symbolic composition system that recursively recombines those concepts into arbitrarily more complex expressions. Work package (WP) 1 will generate maps of mathematical concepts in adults varying in education, using high-resolution single-subject 7T fMRI and MEG. The impact of education will be studied by testing concepts ranging from elementary to advanced, and by comparing adults whose education varies from high-school to professional math. Blind and high-functioning autism subjects will also be tested. WP2 will focus on 5 concepts of central importance in math (geometrical shape, pattern, set, number line, and graph). For each, we will map developmental change by acquiring behavioral and fMRI data in adults and children. The model predicts that concept acquisition can be modeled as a construction of increasingly complex mental expressions whose complexity is predicted by minimal description length (MDL). WP3 will map the brain changes during the acquisition of a math concept. Experiments will test the role of feedback, repetition, retrieval practice, sleep, conceptual diversity, and age, in facilitating behavioral and brain measures of conceptual change. Finally, WP4 will examine whether artificial neural networks can capture the above results and investigate how these networks can be enhanced to achieve human-like performance. Overall, the results will shed light on how mathematical education changes the human brain and how conceptual change occurs, thus paving the way to real-life educational applications in schools.

Keywords: mathematical cognition arithmetic
Design And Modeling of Oxide Catalysts by machine LEarning and atomistic Simulations (DAMOCLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 196829.28
EU funding (EUR): 196829.28
Participants: 2
Project status: SIGNED

The DAMOCLES project aims to apply data-driven modeling (i.e., molecular simulations combined with machine learning) to study and tailor metal oxide catalysts for CO2 hydrogenation processes (reverse water-gas shift, CO2 methanation, and CO2 to methanol), with the final goal of screening oxides in search of new and better catalytic materials. The starting point of the project is the newly-released OC22 oxide data set (from Meta FAIR and Ulissi's group) comprising approximately 50k adsorption energies of relevant molecules on multi-component oxide surfaces spanning 52 elements of the periodic table. State-of-the-art machine learning models (e.g., Gaussian process regression, and graph neural networks), will be applied for the prediction of relevant adsorption energies not included in the sparsely labeled OC22 dataset. New density-functional theory (DFT) calculations will target the adsorption energy of molecules not considered in the data set and activation energies of the elementary reactions of the CO2 hydrogenation paths. The catalytic performances (i.e., activity and selectivity) of the oxide surfaces in OC22 will be evaluated through microkinetic modeling. Active learning will be applied to iteratively improve the model predictions with additional DFT calculations targeting the parameters selected with sensitivity analysis and uncertainty quantification. The overarching goal of the DAMOCLES project is to understand the effects of the structure and composition of the catalyst surface in the processes of CO2 hydrogenation and identify new promising catalytic materials. This insight can guide experimental researchers in the synthesis of oxide materials with improved catalytic performances, thus helping the development of economically sustainable processes for the transformation of waste CO2 into useful chemicals and fuels.

Keywords: catalyst screening multi component oxides atomistic modeling machine learning graph neural networks gaussian process regression
Improving flower attractiveness for pollinators: Study of developmental, morphological and chemical cues in relation to bee foraging (NectarGland)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Animal pollinators are vital for life on earth. While human population keeps growing, pollinator populations are dropping, thus threatening food security. In agriculture, the main insect pollinators are bees, by far. The lack of knowledge on how domesticated plants attract and reward bees has hampered the selection of varieties with improved and mutually beneficial crop-pollinator relationships. We propose to investigate flower features, including developmental, morphological and chemical cues, in relation with bee foraging. Elucidating the molecular basis of these processes would not only help sustain yields, but it is key to understand the co-evolution of plants and pollinators. We chose melon as a model system, because it is a strictly entomophilous crop, and because it provides all flower sexual morphs useful to probe plant-insect interactions. ForBees is a multidisciplinary project that integrates molecular genetic analysis and precise phenotyping. First, we will study melon genetic biodiversity with the aim to identify alleles that control nectar-related traits and bee attraction. The comparative analysis of wild accessions, landraces and breeding lines will further test whether domestication led to the loss of useful traits affecting insect visits. Second, we will analyse the gene networks that drive nectar gland development and nectar production. Finally, potential key regulators will be validated genetically. Through this work, we aim to develop a toolbox to tailor the morphology and chemistry of the flowers towards improved bee foraging activities. In addition to research in melon, results from this project, and from previous works, will be translated into neglected crops of the Cucurbitaceae family. These are major food crops in many developing countries, ensuring food security and generating income for poor farmers. Yet, these crops suffer from low fruit set because of partial pollination and would greatly benefit from enhanced breeding tools.

Keywords: nectar,nectar gland,bees,sex determination,plant breeding,neglected crops