Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Safeguarding Cell Fate by Terminal Repression during Development and Disease (SafeFate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1761489.0
EU funding (EUR): 1761489.0
Participants: 1
Project status: SIGNED

Cell identity and function requires both induction of desired genes and repression of unwanted programs. While master regulators that activate gene networks during development are well characterized, the mechanisms that terminally repress alternative fates remain poorly understood. Within this project, I aim to demonstrate that active terminal repression is a universal mechanism required to prevent loss of cell identity and disease. We recently found that the neuron-specific transcription repressor Myt1l is essential to induce neuronal cell identity. Myt1l is expressed in virtually all neurons throughout life and its loss in mature neurons impairs neuronal gene expression and function, suggesting a role in maintaining cell fate. Unlike known repressors such as REST that specifically silences neuronal genes in non-neuronal cells, Myt1l represses many non-neuronal programs in neurons. I therefore propose that a new class of terminal repressor exists that continuously represses alternative lineages to confer and maintain cell identity. Since Myt1l mutations often occur in autism and schizophrenia I will investigate how loss of terminal repression can contribute to these poorly understood but common mental disorders. This will require molecular and behavioural studies in human and mouse models. We will also investigate how a sequence specific terminal repressor biochemically interacts with general epigenetic machinery to continuously silence unwanted programs during neuronal reprogramming. Finally, we will test candidate terminal repressors in other lineages by loss and gain of function approaches to analyse whether terminal repression is a universal principle of biology. Ultimately this will provide insight into fighting diseases associated with loss of cell identity and to efficiently generate cells for regenerative medicine using reprogramming.

Keywords: cell identity,cell fate reprogramming,transcriptional networks,neuroscience
Oligo-Squaramide Rigid-Rods for Artificial Transmembrane Signaling (SQSig)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

G-protein coupled receptors (GPCRs) are transmembrane proteins that are used by cells to transmit information through their membranes; binding of a ligand to their extracellular region provokes a conformational change, initiating a biological process in the cytosol. Copying this type of signaling pathway, which is fundamental to cells and thus a key target in medicinal chemistry, is a fascinating challenge that could allow researchers to bypass endogenous signaling pathways in cells and lead to true synthetic biology. In this project we propose to exploit the self-assembly properties of squaramides (SQs) to create a relay of information through a bilayer membrane. Monomeric SQs self-assemble as head-to-tail aggregates, forming ribbons with all the SQs oriented in the same direction. We have designed a family of scaffolded oligo-SQ arrays that will form intramolecular hydrogen-bonded ribbons aligned in either one direction or the other. We hypothesize that inverting the directionality of the terminal SQ of the ribbon will initiate a domino effect that switches the orientation of the whole array. By functionalizing the terminal SQ of the oligo-SQ relay with a binding site and the opposite end with a spectroscopic reporter, followed by insertion in model membranes, we will show that binding of an external ligand to the terminal SQ switches the directionality of the entire SQ-ribbon and provokes a spectroscopic response from the reporter located at the other side of the membrane. Thus this system will act as a synthetic GPCR, able to transmit conformational information from one side of a bilayer membrane to the other. The action combines the experience of the researcher in the preparation and study of SQs with the expertise of the host group in the development of transmembrane devices. While the fellow will bring new knowledge in synthetic and supramolecular chemistry to the host group, he will acquire valuable experience in the analysis and biophysics of membranes.

Keywords: biomimetics,transmembrane signalling,large unilamellar vesicles,artificial molecular devices,hydrogen bonds,squaramides,rigid rods
Public Epigraphy in Ancient Italy (third-first centuries BCE) (PEAI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The purpose of this project is therefore to compile palaeo-Italic public inscriptions to analyze their use as a means of social communication from the third to the first centuries B.C. Public epigraphy comprises the inscriptions intended for public display regardless of whether they were the result of an official or private initiative. These texts constitute a peculiar form of social communication which was quite typical in the ancient world. They were used for self representation and to spread and perpetuate a series of solemn messages linked to the fundamental values of society, in particular, the values of its élite. The chosen period, prior to the shaping of the so-called imperial epigraphic culture –which began under Augustus and involved an exponential increase in the ‘epigraphic habit’– is characterized by an incipient proclivity to produce public types of texts and, above all, by a diversity of epigraphic cultures, both with regard to language and script. The work plan consists of producing a census of public inscriptions and cataloguing them in an online database, including the direct analysis of a significant part of the inscriptions. These documents also allow us to study three specific aspects: linguistic changes and the ensuing possible implications on identity; the social groups which promoted them; and the privileged spheres of epigraphic and public communication. The result of my research will be disseminated through publication of papers, a seminar, a conference (PEI) and a monograph. Communication includes a booklet, QR codes, an Instagram account and a didactic activity. As regards my training, this project is fundamental as collaboration with my Supervisor will result in gaining linguistic knowledge to complete my interdisciplinary training, and the secondment will allow me to gain significant experience in Digital Humanities. The MSC allowing me to become a more mature and accomplished researcher capable of directing a research project.

Keywords: epigraphy,pre roman languages,epigraphic culture,ancient italy,fragmentary languages,social communication,oscan,etruscan,venetic,messapian,celtic
Water-to-Air Backscatter Communications (WABCom)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Over 70% of the Earth’s surface is covered by water, while the majority of the underwater areas are unexplored yet. Owing to growing underwater activities, e.g., undersea oil & gas exploration, and Internet of underwater things, reliable water-to-air wireless communications are urgently needed by the industry, military, and scientific communities. As it is difficult to use a single type of signal, e.g., acoustic, radio frequency (RF), or optical, for communication across a water-air interface, most existing water-to-air communications rely on sonobuoys to relay acoustic signals from underwater transmitters to RF receivers on/above the water surface. The global sonobuoy market is predicted to reach $595.9 million at a 6.62% CAGR over the period 2018-2023. Since sonobuoys might not be recovered from remote, hostile areas of the ocean, battery-powered sonobuoys (which have battery packs full of toxic metals) are posing a great threat to the marine environment. Although energy-harvesting technologies (e.g., photovoltaic, wave action, or seawater based semi-fuel cell) have been developed for sonobuoys to charge onboard energy storage systems, the challenge of miniaturizing and incorporating these technologies into the sonobuoy volume constraint remains a dominant issue. This project will develop novel water-to-air backscatter communication (WABCom) technology to enable the design of lightweight, battery-free sonobuoys by leveraging RF backscatter communications, where the RF energy harvested by the sonobuoy from an unmanned aerial vehicle’s (UAV) transmission is used to support the circuit operation at the sonobuoy, and the sonobuoy forwards the received underwater signal to the UAV via an RF backscatter link (i.e., by modulating the signal on the RF waveform reflected back to the UAV). Such miniature battery-free sonobuoys can be flexibly deployed (e.g., air-dropped by UAVs) where and when needed and are disposable with minimum impact on the marine environment.

Keywords: water to air wireless communications,sonobuoy,radiofrequency,backscatter,underwater acoustics,energy harvesting,internet of underwater things,underwater sensor networks
Pamphlets and Patrons: How courtiers shaped the public sphere in Ancien Régime France (PAPA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1948683.0
EU funding (EUR): 1948683.0
Participants: 1
Project status: SIGNED

PAPA will rewrite significantly the story of the emergence of modern politics, re-evaluate Ancien Régime society, and re-assess the origins of the French Revolution. To do so, it will develop a new way to look at the rise of the public sphere in the 18th century. The focus is on the study of political pamphlets: 1) the PI and his team will establish a new paradigm in the research on illegally published writings, and 2) develop a database that will open tremendous new possibilities for future research in intellectual and political history. 1) According to the dominant narrative, early modern France experienced a growth of state authority, and a decline of aristocratic power. While earlier royal authority was allegedly sacral, the Enlightenment era is presented as an epoch that witnessed the rise of the bourgeoisie and gave birth to a new criticism of both aristocracy and absolutism. The French Revolution is supposedly the result of these long-term processual changes. PAPA will question major theses of 17th- and 18th-century studies supporting this narrative, and develop new venues of research in these fields. PAPA’s main hypotheses are that a) courtiers shaped the 18th-century public sphere in a crucial way, b) 18th-century society and politics show more continuities than ruptures to the 17th century, and c) the French Revolution had at its inception much more in common with 17th-century princely uprisings than has been hitherto recognised. 2) The PAPA research team will create the first database devoted to Ancien Régime pamphlets. As several humanities and social sciences have a keen interest in these sources, the significance of PAPA goes largely beyond historical studies. The PAPA database will enable ongoing analyses of the content of these sources. This will greatly facilitate future research on Ancien Régime France and make scholarly results accessible within and outside academia.

Keywords: public sphere,political pamphlets,royal court,courtiers,patronage,enlightenment,ancien r gime,french revolution,france
Augmented Reality Enriched Situation awareness for Border security (ARESIBO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Spain,Italy,Greece,Switzerland,Finland,Romania,Belgium,Bulgaria,Greece,Greece,France,Portugal,Portugal,Portugal
Call: Technologies to enhance border and external security (H2020-SU-SEC-2018, 2018)
Start date: 2019-05-01
End date: 2022-07-31
Duration (months): 39.0
Total project cost (EUR): 6999882.5
EU funding (EUR): 6999882.5
Participants: 21
Project status: SIGNED

ARESIBO aims at improving the efficiency of the border surveillance systems by providing the operational teams and the tactical command and control level with an accurate and comprehensive information. The pillars of research in ARESIBO are three-fold: 1. Set-up a complete configuration at tactical and execution level to optimise the collaboration between human and sensors (fixed and mobile), 2. Improve situation awareness by enhancing the understanding of the situation through adapted processing of sensor data, correlation between heterogeneous data and information and creation of knowledge through deep learning techniques and 3. Create a situation awareness capability at C2 level that will combine reports on previous missions, real time situation understanding and threat analysis for future actions. This capability will be used to optimise the operations (teams deployment and sensor positioning) as well as an online briefing tool for the teams that will be able to access to the results of the previous missions while in the field. ARESIBO integrates research activities in the domain of 1. surveillance platforms (air, ground, surface, underwater) to optimise the collaborative capabilities of the platforms and their positioning (between themselves and with the teams), 2. Sensor processing to interpret, fuse and correlate all the data to produce information and knowledge and 3. Augmented reality techniques to elaborate and provide to the operators a situation awareness picture which is fit for their missions (minimum information for maximal understanding) both as team level and tactical C2 level. The ARESIBO system will be developed incrementally during the 3 years with two major versions that will lead to sub-versions for land and maritime borders. The system will be tested and assessed in 1. a controlled environment enabling testing at any time without pre-requisite authorisations and 2. in real conditions in Finland, Greece, Romania and Portugal for the 2 versions.

Keywords: situation awareness,augmented reality,sensors correlation,command and control
Nanostack printing for materials research (NANOSTACKS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Belgium
Call: FET Proactive: emerging paradigms and communities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-08-01
End date: 2024-07-31
Duration (months): 48.0
Total project cost (EUR): 4021750.0
EU funding (EUR): 3992000.0
Participants: 5
Project status: SIGNED

When compared to fossil fuels only one decisive disadvantage remains for electricity from solar cells and wind mills, namely the difficulty to store this energy in very large quantities and in high energy density. State of the art batteries have a low energy density, and, in addition, cannot handle the needed quantities of energy. In principle, fuel cells could store huge quantities of energy and in in high energy density, but these are not very efficient and, moreover, rely on expensive materials. We want to develop a novel screening method to find efficient fuel cells that rely on cheap materials. KIT developed a novel multi-material nano3D printer that generates ~40.000 nanostacks per glass slide with freely chosen sequential arrangements of printed nanolayers that are made of nanoparticles or organic materials. We want to use this robot to print conductors, isolators, diodes, battery-, fuel cell-, and LED-materials, and then screen ~15.000 twin-nanostacks per glass slide for function. We will start with diodes that are made of a ZnO layer on top of ITO nanoparticles. When positioned in between two capacitor plates, an AC current will drive electrons unidirectional through all of these nanostack-diodes from where they travel back through the adjacent twin nanostack. If this twin nanostack is a functional battery, reduced battery materials are identified in a scanner, while functional LED nanostacks identify themselves through emitted light. Functional LED- or battery-nanostacks will then be used to identify those nanostacks that work as a fuel cell. We think that this new method will advance materials research beyond the screening for novel energy materials.

Keywords: 3d printer,nanostacks,screening,nanoparticles,conductor,battery,fuel cell
Eco-lightweight granules for energy efficient applications (Eco-LWG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Buildings in Europe are responsible for more than 40% of total energy consumption and 25% of carbon emissions, mainly due to the high number of old housing stock with very poor insulation systems. This research will develop new energy efficient materials by engineering eco-lightweight granules (eco-LWG) to mitigate these problems. The eco-LWG will have high strength and high water absorption, ~100 wt.%, and be made from widely available waste materials: recycled mixed coloured glass, clay and limestone. The eco-LWG will be used to contain phase change materials (PCM), which use chemical bonds to store and release heat, allowing control of temperature fluctuations. The high level of porosity in the eco-LWG will allow them to absorb and retain much higher levels of PCM than has previously been possible using existing lightweight aggregates. Both the eco-LWG and the PCM loaded eco-LWG will be optimised by statistical design methodology and they will be used to develop new energy efficient construction products. Two impregnation methods will be compared to introduce the PCM into the eco-LWG: vacuum sorption to achieve maximum PCM uptake and short term immersion to partially fill the connected porosity. These will produce innovative lightweight and high heat-storage materials. Incorporating PCM loaded granules in mortars and other construction materials will result in reduced energy requirements to heat and cool buildings and improve indoor living conditions. The eco-LWG developed in this research will also be used in green roofs to provide water retention capacity and slow nutrient release. Green roofs can reduce the energy requirements of buildings and urban pollution. This multidisciplinary innovative research will deliver new energy efficient construction materials that can contribute to achieving the 2020 target of nearly zero-energy and highly material efficient buildings, which is an essential target to achieve sustainable growth in the EU.

Keywords: lightweight material,waste,high water absorption,statistical design methodology,phase change material,energy efficient material,mortars,building insulation,green roofs
Next generation nanowire solar cells (NEXTNANOCELLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2018-04-25
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Nanowire solar cells are an innovative and promising way to further reduce the cost of photovoltaic electricity for terrestrial applications. Accordingly, the ultimately goal of this project is to develop a multi-junction solar cell composed of an array of III-V nanowire subcells, electrically connected to a state-of-the-art Si solar cell. In order to do so, two different epitaxial techniques will be used to accomplish the epitaxial growth of the nanowires: standard MOVPE growth and the ground-breaking technology of Aerotaxy. Then, the nanowires will be embedded in a polymer and transferred to a Si substrate. The project will be undertaken at Lund University, a world renowned and leading research center in nanoscience and nanotechnology. The project includes not only the development of cutting-edge nanotechnology applied to photovoltaics, but also a comprehensive training program in transferable skills. A secondment in Sol Voltaics AB is also scheduled to assure the inter-sectoral transfer of knowledge, which in turn contributes to the establishment of a knowledge-based European economy. Therefore, the project represents in several ways a valuable opportunity to the researcher and to Lund University.

Keywords: photovoltaics,multi junction solar cells,nanowire solar cells