Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Area-specific transcriptional dynamics and plasticity of neocortical neurons (ArealPlasticity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Cellular diversity in the nervous system determines the variety of circuits that set the framework for brain function. These different types of neurons emerge during pre- and post-natal development through the regulation of gene networks by two archetypical processes: cell-intrinsic processes, which are independent of environmental conditions, and cell-extrinsic processes, which are triggered by environmental signals. A continuum of interactions between intrinsic and extrinsic processes underlie cellular states. However, their respective contribution to neuronal identity has been difficult to untangle because neurons are highly interconnected and heterogeneous cell-types with distinct and dynamic sensitivities to environmental signals. Here, using the mouse neocortex as a model system, I will investigate how cell-intrinsic and cell-extrinsic processes interact to define neuronal identities using Patch-seq assessment of neuronal molecular identity following transplantation across cortical areas. Neuronal “plasticity” will be assessed by transplantation, which corresponds to the artificial altering of the environmental factors. Data comparison between transplanted neurons and controls will identify the candidate of “core genes” which regulate the environment-dependent plasticity of neuronal differentiation. Finally, I will manipulate these candidate genes and analyze their effect on final neuronal identity to validate their causal relationship. Altogether, this study will contribute to revealing the plasticity of neuronal identity across cortical areas and to addressing environment-dependent molecular mechanisms controlling the plasticity. In the long term, this may contribute to a better understanding of neurodevelopmental and psychiatric disorders, in which cell-intrinsic and extrinsic factors interact to produce the disease.

Keywords: self organization,neural differentiation
TrustwOrthy model-awaRE Analytics Data platfORm (TOREADOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Italy,Italy,Italy,United Kingdom,United Kingdom
Call: Big data - research (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 6311218.75
EU funding (EUR): 6311218.75
Participants: 13
Project status: CLOSED

The TOREADOR project is aimed at overcoming some major hurdles that until now have prevented many European companies from reaping the full benefits of Big Data analytics (BDA). Companies and organisations in Europe have become aware of the potential competitive advantage they could get by timely and accurate Big Data analytics, but lack the IT expertise and budget to fully exploit BDA. To overcome this hurdle, TOREADOR takes a model-based BDA-as-a-service (MBDAaaS) approach, providing models of the entire Big Data analysis process and of its artefacts. TOREADOR open, suitable-for-standardisation models will support substantial automation and commoditisation of Big Data analytics, while enabling it to be easily tailored to domain-specific customer requirements. Besides models for representing BDA, TOREADOR will deliver an architectural framework and a set of components for model-driven set-up and management of Big Data analytics processes. Once TOREADOR MBDAaaS will become widespread, price competition on Big Data services will ensue, driving costs of Big Data analytics well within reach of EU organizations (including SMEs) that do not have either in-house Big Data expertise or budget for expensive data consultancy. Activities supported and automatised by TOREADOR will include (i) planning Big Data sources preparation (ii) negotiating machine-readable Service Level Agreements for BDA detailing privacy, timing, and accuracy needs (iii) choosing data management and algorithm parallelisation strategies (iv) ensuring auditing and assessment of legal compliance (for example, to privacy regulations) of BDA enactment. TOREADOR framework will address automatically all major problems of on-demand data preparation, including handling Big Data opacity, diversity, security, and privacy compliance, and will support abstract modelling of the BDA life cycle from distributed data acquisition/storage to the design and parallel deployment of analytics and presentation of results.

Keywords: big data analytics as a service
Synergic Circular Economy across European Regions (SCREEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Coordination and support actions
Countries involved: Italy,Italy,Italy,Spain,Spain,Romania,Belgium,Greece,Croatia,Poland,Belgium,Finland,France,France,Netherlands,Netherlands,Portugal,Portugal,United Kingdom
Call: Smart Specialisation for systemic eco-innovation/circular economy (H2020-CIRC-2016OneStage, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 1742747.5
EU funding (EUR): 1742747.5
Participants: 23
Project status: CLOSED

SCREEN aims at the definition of a replicable systemic approach towards a transition to Circular Economy in EU regions within the context of the Smart Specialization Strategy, through the identification and implementation of operational synergies between R&I investments from H2020 and the European Structural and Investment Funds, thus contributing to novel future eco-innovative and horizontal business models across different value chains. The concept of the action is to develop a EU reference framework for establish operational synergies between Horizon 2020 and the European Structural and Investment Funds related to Circular Economy by: a) Sustaining the regional actors’ participation at H2020 The mechanism of the “vouchers”, already adopted in the past, will be reinforced an harmonized, in order to ensure common rules in EU regions and therefore encouraging to composition of international Consortia applying for circular economy projects related to the regional Smart Specialisation. b) Encouraging the entrepreneurial initiatives based on H2020 project’s results The participating Regions will agree about a specific rule in their Structural Funds giving an advantage for those initiatives targeted to the exploitation of the H2020 project results with a circular economy approach. c) Investigating the possibility of maximizing the H2020 investment through a “recovery”(fully or partial) of well ranked unfinanced proposals dealing with circular economy Even if there is a clear presence of several bureaucratic and operational barriers, a possible solution could have an impressive multiplier effect on the H2020 results. The approach of the action is to leverage on growing industry sectors in EU regions to act as a driver also for the less performing ones, through a circular economy approach, and to support the emergence of new actors in the regional economies leading to new or redesigned value chains.

Keywords: synergic use of h2020 and structural funds for circular economy initiatives dealing with smart spacialisation strategies
Fabricating Functional Components in Room Temperature (FUNCOMP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-11-01
End date: 2020-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Electroceramics are key materials in all electronics. These ceramic components are used for example in sensing of force, acceleration, and humidity, in energy harvesting, and in frequency tuning of antennas and filters. They are also used for miniaturization and packaging of electronics systems and devices. The main disadvantage of electroceramics is that the fabrication requires relatively high investments and it consumes significant amount of energy due to high sintering temperatures (850-2000 oC). This also makes limitations in contacting and an integration with other materials. However, in the last few years realization of electroceramic components with room temperature fabrication (RTF) has become possible. Our ERC project “Printed Electroceramics with Ultimate Compositions” led to extremely interesting discoveries and opens up a totally new horizons to fabricate functional composites at room temperature. The new finding to use densification process of ceramics at room temperature and post-processing at very low (120 °C) temperature opened a utilization pathway for successful multimaterial system integration.We demonstrated that RTF is feasible for realization e.g. dielectrics based on Li2MoO4 ceramics and its composites while new endeavors in integration will be done in this proposed PoC project. Three main application areas, namely wireless 5G, IoT and automotive are all eagerly looking for new approaches for integration, packaging and sensing. In this Proof-of-Concept we will focus on utilization steps to evaluate RTF composite technology in e.g. accelerometer and antenna components so that the first industrially applicable prototypes and samples can be manufactured and demonstrated.

Keywords: electroceramics,ultra low temperature ceramics,functional materials,sensors,energy harvesters,room temperature densification
Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe (EUROoC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Switzerland,Switzerland,Switzerland,Sweden,Finland,France,Netherlands,Netherlands,Netherlands,Netherlands,Luxembourg,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-12-01
End date: 2023-05-31
Duration (months): 54.0
Total project cost (EUR): 3942860.76
EU funding (EUR): 3942860.7600000002
Participants: 23
Project status: SIGNED

EUROoC will create a trans-European network of industrially oriented specialists fully trained in development and application of the emerging Organ-on-a-chip (OoC) technology. OoC technology is advancing at breath taking pace due to its potential impact in drug development and personalised treatments of disease. New researchers entering this field must be equipped with a multidisciplinary background ranging from biology to microfluidic chip engineering. EUROoC will offer the first complete and coherent European training program on OoC by gathering multidisciplinary participants (biologists, physicists, chemists, engineers) in a multi-sectoral network composed of 4 companies (3 SMEs), 2 regulation entities and 10 academic institutions. EUROoC will qualify the next generation of interdisciplinary scientists for all aspects of OoC development and utilisation, including understanding of commercialisation pathways and regulatory aspects. EUROoC furthermore comprises a collection of innovative research projects addressing the development of advanced OoC systems with higher physiological significance going beyond current in vitro testing. The EUROoC project will create advanced OoCs, which closely recapitulate properties of the respective organ tissues in vivo regarding cell types, microenvironment, organ-specific tissue structure and function as well as concepts for the interconnection of individual OoCs. The various OoC models to be developed comprise heart-on-a-chip, bone-on-a-chip, retina-on-a-chip, lung-on-a-chip, adipose- on-a-chip, gut-on-a-chip to liver-on-a-chip. The OoC systems will be able to monitor and analyse tissue functionality and response in situ by integrating various novel sensing elements. The OoCs developed will be pre-validated with the regulatory partners through in vitro-in vivo correlations. The research and training program planned will increase European competitiveness sustainably in this emerging key technology.

Keywords: organ on a chip,tissuechips,microphysiological systems,sensors,induced,pluripotent stem cells,ipsc,disease modelling,toxicity screening,drug development,tissue engineering
Sensitive, spatially resolved U-Th dating approach using LA-ICPMS (SPATULA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

The U-Th dating system is broadly exploited to determine the timing and process of Earth’s geological, environmental, and biotic evolution for materials as young as few years to over the last 800 thousand years (kyrs). Contemporary solution phase U-Th dating protocol using thermal ionization mass spectrometry (TIMS) or multi collector-inductively coupled plasma mass spectrometric (MC-ICPMS) can provide high precision dates with errors of ±1-4‰ (2σ) on ages from 5 to 100s kyr; however, it still restricted by the discrete milli-domain (mm) sampling strategy and the time-consuming chemical preparation procedure. Laser ablation-inductively coupled plasma mass spectrometric (LA-ICPMS) could serve the strengths of rapid, in-situ, and high lateral scanning to U-Th dating. Until nowadays laser U-Th dating approach is sparsely reported due to its reduced sensitivity and precision. Here the experience researcher (ER) designs and employs methods by means of a solution-based correction strategy with a jet-interface setup. This new configuration could essentially reduce the uncertainties and enhance the sensitivity significantly. Based on the ER's previous training, he has firm knowledge and skills in conducting high precision carbonate U-Th dating protocol using MC-ICPMS (Shen, Wu et al., Geochim. Cosmochim. Acta, 2012), and the anlaysis of rare earth elements using LA-ICPMS (Wu et al., Anal. Chim. Acta, 2018). The expected outputs of this SPATULA project are: 1) improve the resolution of age assignments from the milli-domain (mm) to micro-domain (μm). 2) provide in situ analysis using LA-ICPMS to overcome time-consuming element separation processes requiring hazardous chemicals. 3) apply this μm-domain laser U-Th dating approach to tephra-containing stalagmite samples, to reconstruct high resolution volcaican eruption profiles. This sensitive, spatially U-Th dating approach, has the potential to be applied to diverse fields such as oceanograpgy, geomagnetics, and archaeology.

Keywords: isotopic u th dating,la icpms,carbonates
The Integration of Novel Aerospace Technologies (INNOVATIVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 3767040.0
EU funding (EUR): 1883520.0
Participants: 1
Project status: CLOSED

INNOVATIVE will enable the systematic integration of novel aerospace technologies through the training of 24 researchers through a comprehensive multidisciplinary programme. INNOVATIVE is about the exploration of game-changing and disruptive technologies, materials, methods and processes for the aerospace sector AND their impact and interactions in the context of the virtuous pyramid of interdependences (in aerospace) spanning weight, cost, energy and the environment, and the human experience and safety. INNOVATIVE will aim to deliver a step-change in the training of Early Stage Researchers (ESRs) in aerospace technologies by providing a comprehensive programme that will empower these researchers with a multidisciplinary skillset comprising tools, techniques and methods suitable for pursuing careers in Aerospace Technology and related fields. Flightpath 2050 sets out a vision for a future aerospace industry with “A network of multidisciplinary technology clusters” being at the heart of technology development to keep Europe competitive in this strategically important global industry. The programme has been specifically designed to meet the future skills needs of the aerospace industry, but is applicable to a wide range of industry sectors where traditional disciplinary boundaries need to be eroded and replaced with multidisciplinary skills. The individual researcher trained through this programme will have a novel skillset that separates them from their competitors and will be attractive to take up high-powered roles in industry, where they can nurture teams with a mindset that allows for multidisciplinary thinking and systems thinking.

Keywords: aerospace,aero engines,airframes,power electronics and electrical systems
Beyond Precision Cosmology: dealing with Systematic Errors (BePreSysE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1835220.0
EU funding (EUR): 1835220.0
Participants: 1
Project status: SIGNED

Over the past 20 years cosmology has made the transition to a precision science: the standard cosmological model has been established and its parameters are now measured with unprecedented precision. But precision is not enough: accuracy is also crucial. Accuracy accounts for systematic errors which can be both on the observational and on the theory/modelling side (and everywhere in between). While there is a well-defined and developed framework for treating statistical errors, there is no established approach for systematic errors. The next decade will see the era of large surveys; a large coordinated effort of the scientific community in the field is on-going to map the cosmos producing an exponentially growing amount of data. This will shrink the statistical errors, making mitigation and control of systematics of the utmost importance. While there are isolated and targeted efforts to quantify systematic errors and propagate them through all the way to the final results, there is no well-established, self-consistent methodology. To go beyond precision cosmology and reap the benefits of the forthcoming observational program, a systematic approach to systematics is needed. Systematics should be interpreted in the most general sense as shifts between the recovered measured values and true values of physical quantities. I propose to develop a comprehensive approach to tackle systematic errors with the goal to uncover and quantify otherwise unknown differences between the interpretation of a measurement and reality. This will require to fully develop, combine and systematize all approaches proposed so far (many pioneered by the PI), develop new ones to fill the gaps, study and explore their interplay and finally test and validate the procedure. Beyond Precision Cosmology: Dealing with Systematic Errors (BePreSysE) will develop a framework to deal with systematics in forthcoming Cosmological surveys which, could, in principle, be applied beyond Cosmology.

Keywords: analysis of forthcoming large cosmological surveys
Universal mid-air haptic feedback (UTOUCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 2131705.0
EU funding (EUR): 1492193.5
Participants: 1
Project status: CLOSED

Ultrahaptics is the first and only company in the world to create a novel haptic feedback system that allows users to feel sensations in their bare hands while interacting in mid-air with a touchless sensing system. We use an array of ultrasonic speakers to create mid-air feeling without touching. Invisible forces are projected into the air and felt on human skin up to 1 metre away from the device. The activities planned in our project will allow us to create three routes to market – the bespoke solutions, the development kits (Dev Kit) and business-to-business (B2B) products. Within this project we will expand and actively pursue the Dev Kit and B2B route, where we will make development platforms and completed products available to companies that want to integrate Ultrahaptics in their applications. In the Dev Kit route, we will create embedded Ultrahaptic systems based on standard microprocessors that are offered with development boards (WP4) and software tools (WP3). This will allow a large range of small and medium enterprise companies to write their own applications without needing to go through our evaluation programme. In the B2B route, we will create simple ubiquitous modules such as touchless buttons with tactile feedback. To enable us to target a wide range of markets, we will pursue the Dev Kit and B2B route for 3 sizes of firmware - U5 which is closest to what we already have in-house in terms of processing speed and number of transducers required, U7 which maximises performance and features and U3 which is a low-cost solution. The most relevant market segments for initial introduction of the project solutions are Automotive (U5), computing and gaming (U7) and home appliances (U3).

Keywords: touchless,haptics,ultrahaptics,embedded firmware