Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Open Framework of E-Services for Multilingual and Semantic Enrichment of Digital Content (FREME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Germany,Italy,Ireland,Germany,Belgium,Greece,Latvia
Call: Big data and Open Data Innovation and take-up (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 3606751.44
EU funding (EUR): 3212626.0
Participants: 10
Project status: CLOSED

The aim of the FREME innovative action is to establish an “Open Framework of E-Services for Multilingual and Semantic Enrichment of Digital Content”. Six enrichment services will be designed, piloted, and validated during the action. Their innovation, usability, and robustness will be shaped by four real world business cases that will bring FREME data innovation and technology transfer directly to the market: (1) authoring and publishing multilingually and semantically enriched eBooks; (2) integrating semantic enrichment into multilingual content during localisation; (3) enhancing cross-language sharing and access to open data and (4) empowering personalised content recommendations. FREME innovation will lead to new business models for digital content and Big Data markets and will contribute to EU competiveness and new job profiles in the digital content management realm. FREME addresses specific challenges of topic ICT 15-2014: 1) FREME will improve the ability of EU companies to build innovative multilingual data products and services by providing six innovative, user-friendly, and robust enrichment services that are accessible both via APIs and GUIs; 2) FREME will remove technological barriers for multilingual content technologies by allowing to use data assets in an interoperable, reusable, and aggregatable way across sector, borders, and languages; 3) FREME will transfer existing mature multilingual and semantic technologies and cloud-based infrastructures previously developed by partners and available on their 7, 8, or 9 technology readiness level for action as value-adding components to content and data value chains during; 4) FREME business cases will validate the action concept, approach, and ambition within the entire content and data value chain. The core of the FREME consortium are companies who define business cases, partners who shape data innovation and technology transfer including their expertise in market validation and business modelling and planning.

Keywords: innovation,technology transfer,data value chain,digital content,semantic content,multilingual content,enrichment service,business case and model,market validation,sme growth
Polymer Solvation with COSMO-RS (PolySolv)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 105000.0
EU funding (EUR): 105000.0
Participants: 1
Project status: CLOSED

SCM is a scientific software company with a track record of over two decades of translating scientific advances into commercial success. The company’s strength has traditionally lied in electronic structure methods, its flagship product being the well-known ADF package. In recent years SCM has been broadening its scope to add approximate, faster methods. One of such methods is the COnductor-like Screening MOdel for Realistic Solvation, COSMO-RS, a powerful continuum solvation model. COSMO-RS is able to predict thermodynamic properties in solutions in an efficient and general way, and has proven to be one of the modules with the fastest-growing demand within SCM’s portfolio – the company’s revenues from COSMO-RS have increased almost 130% over the last two years. COSMO-RS is therefore a key component of SCM’s growth strategy. However, our COSMO-RS implementation has one important limitation, as it cannot deal with molecular models above a certain size. And the ability to predict thermodynamic properties in larger molecules, and in particular polymers, is of great relevance in many areas (e.g. food packaging, coating technology, membrane separation and drug development). SCM therefore plans to extend its COSMO-RS implementation to allow for molecular models of any size, in order to increase our market share in the field of polymer chemistry. There are several possible routes to accomplish that (such as fragment-based methods or equations of state (EOS) approaches) but they all require a level of expertise in thermodynamics and continuum models currently lacking within SCM. This is highly specialized work, which falls outside SCM’s strengths in electronic structure methods, and the company needs to recruit skills combining expertise in continuum solvation models as well as modern software development techniques. Such developments would extend the market for SCM’s COSMO-RS implementation, allowing the company to tap into the huge market of polymer chemistry.

Keywords: modelling of polymer solvation,software development,cosmo rs,commercialisation of scientific results,new markets
EU-China Innovation Platform on Sustainable Urbanisation (URBAN-EU-CHINA)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Italy,Belgium,China,Norway,France,France
Call: EU-China cooperation on sustainable urbanisation (H2020-SC6-ENG-GLOBALLY-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 13
Project status: CLOSED

The key objective of URBAN-EU-CHINA is to develop a robust, evidence-driven bottom-up approach to complement the existing top-down EU-China strategic approach to sustainable urbanisation. This will be accomplished via a coordinated series of actions including: a strategic R&I agenda, scoping and assessment, networking events, peer-to-peer exchanges, benchmarking and monitoring, and joint demonstration projects. By creating tighter coupling between city-level, national, and supra-national programmes, planning, policies, and projects, URBAN-EU-CHINA will yield a significant increase in cooperative EU-CHINA R&I activities. The key barrier addressed by URBAN-EU-CHINA is the disconnect between strategic visions and targets and operational realities of time/resource constraints, language and cultural barriers, differences in planning/policy/ governance framework conditions within European and Chinese cities, and lack of effective bi-directional transmission mechanisms of transferable planning and policy instruments for sustainable urbanisation. The topic ENG-GLOBALLY-08-2016-2017 asks for the creation of an EU-China Innovation Platform on Sustainable Urbanisation. Creating such a platform is complex and cross-sectoral by nature, aiming to engage policy makers, national authorities, industries, cities, academia, civil society and other stakeholders in order to develop more sustainable cities. In URBAN-EU-CHINA, 12 experienced European and Chinese consortium partners from across the sustainable urbanisation value chain join forces to support the European Commission in its aim to make EU-China sustainable urbanisation cooperation more accessible, attractive, and rewarding for a broader set of stakeholders.

Keywords: city industry science partnerships,stakeholders,peer to peer,cross sectoral,linkages,alignment,monitoring,assessment,mobilise,learning,cooperation,policy strategies,joint projects
FRESHDETECT – food safety – fast and reliable (FRESHDETECT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 1972337.5
EU funding (EUR): 1380636.25
Participants: 1
Project status: CLOSED

600 million (about 1 in 10 people) in the world fall ill after consuming bacteria contaminated food. Of these, 420,000 people die, including 125 000 children under the age of 5 years. Worldwide approximately 1/3 of all food produced is lost or wasted, requiring cropland area the size of China and being responsible for 8% of all global Greenhouse Gas Emissions. In the EU, every year 88 million tonnes of food are wasted related with costs estimated to be 143 billion euros. FreshDetect GmbH aims to contribute to a solution of these problems with the first mobile handheld device developed for rapid determination of the microbiological quality of food (currently meat products). The FreshDetect device enables non-invasive microbiological testing without additional operational or maintenance costs. For the first time, the handheld allows hygiene monitoring through the complete meat production process and creates a new dimension of food safety. Moreover, the FreshDetect technology offers a so far unmatched level of food process control allowing an optimization of the food production and minimizing food waste. The current determination of total microbial count in laboratories outlined by §64 of the LFGB (German Food and Feed Code) takes about 72 hours to properly determine contamination. This renders impossible any process control that is based on food contamination. The FreshDetect hand-held device needs only 5-10 sec. for the same process, is much less costly and does not need scientific trained operators or lab technician. Starting with pork meat and having analysed the top 10 food processing European countries, FreshDetect’s market potential is 284,000 devices with a market volume of € 3.5 billion. The target users are slaughterhouses, cutting plants, meat processing companies, retailers, wholesalers and butchers. The goal of the project is to bring our current prototype (TRL7) to business success with commercialization to these users.
Exploring the onset of Anthropocene in the Upper Jordan valley (Hula lake) (GEOLAKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The overriding aim of GEOLAKE is to disentangle the effects of climate change and anthropogenic activities on the environment and to highlight the long-term adaptation of populations in the Upper Jordan Valley (Israel) using sedimentary, palaeoecological and geochemical proxies from the lake Hula as unique case-study example. The lacustrine archives of the Hula will facilitate a high-resolution reconstruction of human-environment dynamics since the emergence of the region’s first complex societies in the Early Neolithic. In this part of the Levant, the Holocene is a key period during which environmental changes and human pressures profoundly transformed local ecosystems providing new key knowledge to constrain the concept of the Anthropocene in the region. The comparison of palaeoenvironmental data generated within the framework of our project with archaeological and historical evidence will allow us to develop an innovative “local human occupation index” to understand the evolution of the human pressures in the Hula catchment and to propose models looking to: (1) understand how ancient societies perceived and reacted in the face of environmental and climatic changes; (2) understand how they lastingly modified their environment; (3) estimate how their methods of environmental management were influenced by external variations. The Institute of Environmental Science and Technology (ICTA) at the Autonomous University of Barcelona (UAB) is the ideal institutional environment to develop the proposed research during the course of the fellowship and beyond. The researcher will be trained and integrated into in a strong collaborative and multidisciplinary network. This fellowship will reinforce the research experience, transferrable skills, audience and outreach, and will thus be crucial for his future career. Furthermore, the project will rest upon strong collaborations with Israeli scientists who are excavating in the region since several decades.

Keywords: geoarchaeology,anthropocene,human environment interactions,human adaptation,molecular biomarkers,environmental dynamics,climate change,jordan valley,lake hula,levant,fertile crescent
Race Land: The Ecology of Segregation (RACELAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-10-02
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: SIGNED

RACELAND investigates how white-supremacist social systems affect people and the environment on a worldwide scale. Taking an innovative interdisciplinary approach, its aim is to examine how race and class discrimination globally interlocks with economic development, ecological issues, medical research, and the advancement of science more generally. The focus of this project is on a modern and quintessential white-supremacist society: the segregationist South of the U.S. during the Cold War era. Often considered a regional backwater that was out of step with modernity, I apply a radically different perspective that places the South at the center of U.S. policymaking and racialized innovation in the post-World War II period. RACELAND emphasizes the ingenious strategies southern segregationists employed to keep their racist worldview intact and export its main tenets across the globe, with profound consequences for ecosystems around the world and for the populations inhabiting them. The legacy of such strategies continues until today. The project addresses pressing current questions regarding social and environmental justice, which cannot be answered unless we know more about their historical context, about when and why these problems arose in the first place. Considering the recent rise of reactionary populism and the alt-right movement, my proposal is incredibly timely, because it exposes the complex and entangled roots of this right-wing upswing. The training objectives of the Fellowship are aimed at research, management, and public outreach. The Fellowship will enable me to learn advanced intellectual and management skills as part of an outstanding interdisciplinary team of scholars at the Center for the Study of Southern Culture. Moreover, it will enhance my abilities to raise public awareness through cooperation with expert journalists, online platforms that publish about themes connected to my research, and institutes engaged in community outreach.

Keywords: racial segregation,race relations,regional studies,rural studies,u s history,u s south
Unravelling the mechanism of eukaryotic helicase activation (MechHelicaseActiv8on)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome duplication only once per cell cycle. During eukaryotic replication initiation, the MCM helicase is loaded as an inactive double hexamer encircling double-stranded DNA (dsDNA). It is activated by a set of proteins called firing factors in a kinase-dependent manner, thereby forming the CMG complex (Cdc45, MCM, GINS), which encircles single-stranded DNA (ssDNA) and thus can unwind dsDNA. Although the essential components for helicase activation are known, we do not understand the remarkable topological transition between the inactive helicase encircling dsDNA and the active helicase encircling ssDNA. For this to happen, the ring-shaped MCM helicase must open between two subunits in a regulated manner. Therefore, I aim to (1) uncover the trajectory of ssDNA ejection from the helicase central channel and (2) dissect the role of firing factors in helicase activation. The objectives of the proposal are to determine (i) which helicase subunit interface has to open to eject ssDNA, (ii) which region of helicase interacts with ssDNA during helicase activation, (iii) what is the topology of helicase activation intermediates and (iv) which firing factors interact with ssDNA during strand ejection. I will employ biochemistry with various crosslinking strategies combined with mass spectrometry to characterize the dynamics of protein-protein and protein-DNA interactions during helicase activation. Using cryogenic-Electron Microscopy (cryo-EM), I will investigate the structure of intermediates of helicase activation. MCM helicase subunits and firing factors are conserved from yeast to humans, and their increased expression is correlated with poor survival in cancer patients. Since flexible interfaces of protein-protein interactions are promising drug target, results obtained during this project will facilitate anticancer drug design.

Keywords: dna replication,protein protein interactions,nucleoprotein complexes,helicases,cryo em,crosslinking mass spectrometry,replication initiation
Making Biological Minds (MBM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-07-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The ER (Dr Sean Dyde) is a promising early career researcher, having obtained his PhD in 2014 and published 5 articles in top-tier journals and respected edited collections, whose main focus to date has been the history of the biomedical sciences. The PI (Professor Gregory Radick), has published extensively across the history of the human sciences, has experience leading national and international projects, and has engaged in many public engagement activities. The host institution (Leeds) is an internationally renowned centre of research with strengths in the history and philosophy of science. The project's overall objective is to use state of the art research in the history and philosophy of science to reposition current debates over the role of the neurosciences in defining human nature, by placing the relations between the sciences and the humanities into historical perspective. This project builds upon the ER's established research expertise in the history of the biomedical sciences, but with the support of the PI and the host institution, the scope of his work will be extended into the history of the humanities. The ER's 5-10 year career aim is to expand his areas of expertise into the history of the British human sciences and the history of German philosophy and medicine. This project maps a path to achieve this by connecting his existing expertise in the history of the biomedical sciences with the history of the humanities and the reception of German philosophical ideas into Britain during the nineteenth century. Europe remains a world-leader for research into the history and philosophy of science, and this project will allow the ER to progress in his academic career and consolidate links between English- and German-speaking scholars. Work produced by the project will be used by researchers in Europe as it will advance new historiographical positions, develop important connections between different sub-fields, and contribute to current debates.

Keywords: history of the neurosciences,mind body relations,eighteenth century britain,nineteenth century britain,circulation of ideas
Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Finland,United Kingdom,Portugal
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999996.25
EU funding (EUR): 999996.25
Participants: 4
Project status: CLOSED

Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet) aims to promote collaborative multidisciplinary and translational research by enhancing effective knowledge transfer, exchange of best research practices, and the mobility of early stage researchers between the Instituto de Medicina Molecular (IMM) at the University of Lisbon, the University of Eastern Finland, the University of Rome La Sapienza, and the Lancaster University at UK. IMM has widely recognized research groups in basic or clinical neuroscience but aims to foster translation. SynaNet partners are strong in translational approaches and will allow bridging this gap at IMM. Research topics cover ageing, neurodegenetrative and neuroexcitability diseases (either with psychiatric or neurologic expression), neuroinflammation, neuronal synchronization/desynchronization. SynaNet seeks similarities/dissimilarities among those dysfunctions focusing on synaptic and network function/dysfunction. Bidirectional interactions among SynaNet group leaders already gave rise to joint publications in reputed journals. As tools, SynaNet will organize scientific meeting, workshops and summer schools, and will actively promote short term scientific missions in and out IMM, which will allow technology transfer between partners. An External Advisory Committee composed by members of SMEs and of Patient Organizations is also expected to contribute to business training of students. SynaNet activities will be easily transferred at the University level, in particular to the Mind-Brain College of the University of Lisbon, headed by the coordinator of SynaNet (AM Sebastião). It integrates 3 PhD programmes and 7 Schools and aims at the crossed fertilization between cognitive sciences, brain sciences and social sciences. Public debates will foster the societal impact of SynaNet.

Keywords: synaptopathies,neuronal function and dysfunction,neuronal basis of neurologic and psychiatric diseases