Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing Genetic Tools to Mitigate the Environmental Impact of Dairy Systems (GREENHOUSEMILK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,Belgium,Ireland,Sweden,United Kingdom,France,Ireland,United Kingdom
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 2173481.0
EU funding (EUR): 2173481.0
Participants: 10
Project status: CLOSED

The EU25 produce approximately 132 million tonnes of milk from 24.3 million cows on 1.76 million farm holdings. Ruminant animals account for up to 20% of the world methane production with the EU25 dairy population producing approximately 3.2 million tonnes of methane (CH4) per year. Many EU countries have specific and binding commitments relating to the reduction of GHG emissions, and all sectors of the economy are coming under increasing scrutiny in relation to their share in the overall emissions target. Little work has been done on the role of dairy cow genetics in dairy system emissions, particularly considering the role of genetics in the whole farming system, including feeding strategy and management policies (e.g., energy balance, housing periods, fertilisation and manure management). GREENHOUSEMILK will help us understand the role of energy efficiency and partitioning in the overall GHG output of dairy systems and develop innovative tools to help farmers’ select “environmentally friendly” bulls to suit their system and how to manage those bulls’ daughters in an appropriate manner. GREENHOUSEMILK will harness statistical and genetic tools to elucidate the genetics of emissions in dairy cattle and develop innovative and integrative tools that address the environmental impact of dairy farming, thus underpinning a high priority policy area. GREENHOUSEMILK will build on data, resources and expertise being developed in the FP7 KBBE-2007-1 funded project RobustMilk. Utilising the resources and skills from RobustMilk to address other questions is highly beneficial and synergistic and will add to the outcomes of both projects. GREENHOUSEMILK will examine: 1. causes of variation in CHG emissions in dairy cows, 2. genomic tools to help select for reduced CHG emissions, 3. integrating animal CHG emissions into farm systems models and, 4. developing selection indices that include environmental impact.

Keywords: dairy animals,animal breeding,genomics,global change mitigation strategies (climate change),agricultural science (climate change),environmental economics,bioenergetics
PARticle Systems: Training on DEM simulation for industrial and scientific applications (PARDEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,France,United Kingdom,Netherlands,Austria,Germany,Germany,Germany,Germany
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 3243311.01
EU funding (EUR): 3243311.01
Participants: 11
Project status: CLOSED

The overarching aim of the PARDEM project is to provide high quality training to a group of young researchers to work within and to further develop the multidisciplinary field of DEM computational simulation of granular processes. Granular materials are estimated to constitute over 75% of all raw material feedstock to industry. They also present many challenges for innovation and fundamental science to solve problems in areas as diverse as natural disasters and industrial material handling which incur extensive economic losses. The Discrete Element Method (DEM) is a promising supradisciplinary facility providing both visual and quantitative details of the dynamics of particle assemblies. Although the method is established in academia, immature quantitative prediction capabilities and lack of DEM experts due to its rapid development hinder its use as an industrial engineering tool in Europe. To overcome this state a consortium of 6 industry and 5 academic partners is formed which engages the three key stakeholder groups (industrial users, DEM software developers and universities), vital for transforming DEM from a largely scientific tool into a widely adopted industrial tool and delivering increased competitiveness to the EU economy with significantly reduced development times of more efficient processes. The programme will provide for each fellow: a) in-depth training by research at the host site and on industrial secondments; b) sound multidisciplinary and intersectoral scientific training and understanding of industrial environments via courses and secondments; c) a programme of complementary skills training and network events to develop the researchers competencies and career options. The resulting new generation of DEM experts will speak a common language avoiding costly misunderstandings in commercial interactions of the three groups and drive the DEM technology to a level which will change the way equipment and granular processes are designed in EUROPE.

Keywords: discrete element method,granular material,particle technology,computer simulation,chemical engineering,civil engineering,mechanical engineering,agricultural engineering,process industry,geotechnics
Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications (PHOSCHEMREC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Italy,Sweden,Finland,United Kingdom,Belgium,Germany
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 2535051.0
EU funding (EUR): 2535051.0
Participants: 10
Project status: CLOSED

Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.

Keywords: organic chemistry,molecular design,de novo design,pharmaceutical chemistry,chemistry
Pan-European infrastructure for management of marine and ocean geological and geophysical data (GEO-SEAS)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: United Kingdom,Netherlands,France,France,Netherlands,Germany,Spain,Portugal,Greece,Ireland,Germany,Italy,Denmark,Norway,Poland,Estonia,Lithuania,Bulgaria,United Kingdom,Belgium,Spain,Ireland,France,Latvia,Netherlands
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-05-01
End date: 2013-01-31
Duration (months): 45.0
Total project cost (EUR): 6760422.0
EU funding (EUR): 4900000.0
Participants: 30
Project status: CLOSED

The overall objective of the Geo-Seas project is to effect a major and significant improvement in the overview and access to marine geological and geophysical data and data-products from national geological surveys and research institutes in Europe by upgrading and interconnecting their present infrastructures. The Geo-Seas partnership has taken a strategic decision to adopt the SeaDataNet interoperability principles, architecture and components wherever possible. This approach allows the Geo-Seas upgrading to gain instant traction and momentum whilst avoiding wasteful duplicative effort. It is envisaged that the SeaDataNet infrastructure will provide a core platform that will be adaptively tuned in order to cater for the specific requirements of the geological and geophysical domains. A range of additional activities for developing and providing new products and services is also undertaken in order to fulfill the diverse needs of end-user communities.

Keywords: geology,gephysics,e-infrastructure,data management
The Heliophysical Integrated Observatory (HELIO)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: United Kingdom,Switzerland,France,France,United Kingdom,France,Italy,Ireland,United States
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-06-01
End date: 2012-11-30
Duration (months): 42.0
Total project cost (EUR): 4482679.0
EU funding (EUR): 3100000.0
Participants: 11
Project status: CLOSED

The Heliophysics Integrated Observatory, HELIO,will deploy a new Europe-wide distributed network of services that will address the needs of a broad community of researchers in heliophysics.This new research field explores the “Sun-Solar System Connection” and requires the joint exploitation of solar, heliospheric, magnetospheric and ionospheric observations. HELIO will provide the most comprehensive integrated information system in this domain; it will coordinate access to the distributed resources needed by the community, and will provide access to services to mine and analyse the data. HELIO is designed around a Service-oriented Architecture. The initial infrastructure will include services based on metadata and data servers deployed by the European Grid of Solar Observations (EGSO; IST-2001-32409).We will extend these to address observations from all the disciplines of heliophysics; differences in the way the domains describe and handle the data will be resolved using semantic mapping techniques.Processing and storage services will allow the user to explore the data and create the products that meet stringent standards of interoperability.These capabilities will be orchestrated with the data and metadata services using the Taverna workflow tool. HELIO will address the challenges following the I3 activities model: Networking – we will cooperate closely with the community to define new standards for heliophysics and the required capabilities of the HELIO system; Service – we will integrate the services developed by the project and other groups to produce an infrastructure that can easily be extended to satisfy the growing needs of the community; Joint Research – we will develop search tools that span disciplinary boundaries and explore new types of user-friendly interfaces HELIO will be a key component of a worldwide effort to integrate heliophysics data and will coordinate closely with international organizations to exploit synergies with complementary domains.

Keywords: virtual observatory,sematics,workflow,services,heliophysics,ivoa
Semantic Evaluation at Large Scale (SEALS)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Spain,United Kingdom,Germany,Austria,France,Germany,Switzerland,United Kingdom,United Kingdom,Austria
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-06-01
End date: 2012-06-30
Duration (months): 37.0
Total project cost (EUR): 4709423.0
EU funding (EUR): 3499998.0
Participants: 10
Project status: CLOSED

The goal of the SEALS project is to provide an independent and extensible infrastructure that allows the remote evaluation of semantic technologies and, therefore, the objective comparison of the different existing semantic technologies. This will allow researchers and users to effectively compare the available technologies, helping them to select appropriate technologies and advancing the state of the art through continuous evaluation. The SEALS Platform will provide an integrated set of semantic technology evaluation services and test suites. They will be used in two public and world-wide evaluation campaigns. The results of these evaluation campaigns will be used to create semantic technology roadmaps identifying sets of efficient and compatible tools for developing large-scale semantic applications. The semantic technology evaluation services will initially be available for five different types of technologies (ontology engineering tools, storage and reasoning systems, matching tools, semantic search tools, and semantic web service tools) and for different evaluation criteria (interoperability, scalability, etc.). The platform will provide easy and free access to the evaluation services and to the results of the evaluations performed.

Keywords: infrastructure,evaluation,semantic technologies
Data Infrastructure Ecosystem for Science (D4SCIENCE-II)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: France,Italy,Greece,Switzerland,United Kingdom,Italy,Philippines,Hungary
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 5438568.0
EU funding (EUR): 4300000.0
Participants: 10
Project status: CLOSED

D4Science-II will develop technology to enable interoperation of diverse data e-Infrastructures that are running autonomously, thereby creating e-Infrastructure Ecosystems that can serve a significantly expanded set of communities dealing with multidisciplinary challenges whose solution is currently beyond reach. Furthermore, D4Science-II will bring together several scientific e-Infrastructures established in the areas of biodiversity, fishery resource management, high energy physics, etc., to set up a prototypical instance of such Ecosystem. This will support several critical scientific scenarios that are distinct but also feed into and enrich each other in nontrivial ways. Finally, possibly in collaboration with appropriate international bodies and initiatives, D4Science will take steps to ensure sustainability of the Ecosystem, some of them based on and synchronized with the dissemination, training and standardization activities of the project. Technologically, D4Science-II constitutes a continuation of the DILIGENT and D4Science projects, which have initiated an effort towards using existing network, grid, and repository infrastructures to deploy on top of them a pan-European research e-Infrastructure that will enable unlimited generation and dissemination of scientific knowledge. As the next step towards this goal, D4Science-II will transform the current, operational D4Science e-Infrastructure into the linchpin of an e-Infrastructure Ecosystem, holding together and mediating between all participating e-Infrastructures through programmatically-available interoperability services. The D4Science-II Ecosystem will include among others, the GENESI-DR and DRIVER repository e-Infrastructures, and important thematic repositories maintained by international organizations, e.g., INSPIRE and AquaMaps. The project will create Virtual Research Environments offering significantly enhanced services to scientist without incurring high development and maintenance costs.

Keywords: data e-infrastructure,grid,scientific applications,virtual research environments
Biochemical and behavioral characterization of miRNA-mediated regulation of circadian rhythms in Drosophila. (CIRCADIAN RHYTHMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A prominent theme in biology is the mechanism underlying the response of organisms to changes in their environment. miRNAs are small non-coding RNAs that serve as post-transcriptional regulators of gene expression. Translational control by miRNAs is emerging as a major regulatory component of many developmental, physiological and metabolic pathways. However, little is known about their role in behavior and more specifically in circadian rhythms. Circadian rhythms are endogenous and self sustained 24 hs rhythms that drive a plethora of physiologic and behavioral processes. During my post doctoral training, I have demonstrated that miRNAs are involved in the generation and output pathways of the circadian clock. Moreover, I discovered that the master circadian gene, the transcription factor Clk is regulated by the miRNA bantam. To reach this conclusion I have developed new methodologies for the study of miRNAs and their mRNAs target in neuronal tissue. These include an experimental procedure to identify miRNA-regulated genes (RISC immuno-precipitation followed by microarray analysis) and a new approach to identify miRNAs expressed in a cell population without dissection and cell purification approaches (cell-specific inhibition of the miRNA biogenesis pathway followed by tiling array analysis). The present proposal is focused on deepening my recent discoveries and on characterizing the mechanisms by which miRNA-mediated regulation controls the circadian clock at the biochemical and behavioral levels. For doing so, I plan to study: a) the components of the circadian machinery regulated by miRNAs; b) how this regulation is achieved; c) other behavioral processes that are also regulated by miRNAs. In particular I plan to dissect the mechanism by which Clk translation is regulated by miRNAs.

Keywords: circadian rhythms,mirna,translation,rna,bantam,clock,period
Second generation BIOethanol process: demonstration scale for the step of Lignocellulosic hYdrolysis and FErmentation (BIOLYFE)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: Italy,Denmark,Italy,Sweden,Germany,Denmark,Germany
Call:  (FP7-ENERGY-2008-TREN-1, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 15308566.63
EU funding (EUR): 8599461.0
Participants: 9
Project status: CLOSED

The overall goal of BIOLYFE PROJECT is to developing and demonstrating the hydrolysis and fermentation steps at industrial scale of the lignocellulosic bioethanol process, considering the entire chain (i.e. including at the same scale the up-stream and downstream process, namely innovative pre-treatment steps and product separation/utilization). BIOLYFE specifically seeks technologies which have the highest undiscovered potential to enhance the technical and economic feasibility of the hydrolysis and the complete conversion of all sugars into ethanol through an optimized fermentation process. The focus of BYOLIFE is to demonstrate at significant industrial scale (20.000 tonEtOH/y) of innovative 2nd generation ethanol technologies, transferring research results into industrial activities and paving the way to large industrial production (200.000 tonEtOH/y). The aims of BIOLYFE are: - Optimization and improvement of the Hydrolysis process in order to increase the monomeric sugar yield and to reduce accumulation of inhibitors with a feasible and economic production of specific lignocellulosic enzymes cocktails. - Reduction of the viscosity by a Liquefaction of the solid content stream in order to guarantee a constant and continuous flow of the material into the fermenters. - Improve flexible process of Fermentation by the utilization of high performance fermentation micro-organisms that would efficiently co-ferment hexoses and pentoses and tolerate high concentrations of ethanol and the inhibitory compounds. - Design, Construction, commissioning, start up and testing campaign of an industrial demonstration plant based on innovative technologies specifically focused on the enzymatic hydrolysis and fermentation steps, able to produce 20.000 ton/y of Ethanol and to treat up to 80.000 ton/y of inlet selected biomasses. - Distribution and use of bioethanol products under real operational conditions, thus including installation of a distribution system and use in vehicles.

Keywords: bioethanol,ethanol,biomass,feedstock,lignocellulosic,cellulose,hemicellulose,hydrolysis,fermentation,pretreatment,renewable,enzyme,microorganism,demo unit,industrial demo plant,biofuel