Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BENE Innovation Internationalisation services 2020-2021 (BENE I2 2020-2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 94013.75
EU funding (EUR): 75224.0
Participants: 2
Project status: CLOSED

The project aims at offering specific innovation services to 2 different groups of SMEs based in the Brussels Capital Region: - the SMEs beneficiaries of the H2020 European Innovation Council (EIC) Pilot and its funding schemes on the one side, and - the SMEs having a high potential for growth and internationalisation by the enhancement of their innovation management capacity on the other side. These services will be an integral part of the Enterprise Europe Brussels services and will be provided in the frame of a sounded client's journey approach, in line with the company's life cycle. Although for the beneficiaries of the H2020 Enhanced European Innovation Council Pilot funding schemes the proposer depends on the number of successful SME granted and notified by EASME, a funnel approach will be adopted for both groups of SMEs in order to have an upstream estimation and selection of the SME potential existing in the region. This funnel and selective approach will also take into consideration the permeable frontiers which divide one SME group from the other, in the light of the innovation needs and capacities existing at a given time of the SME lifecycle. The service provision for Group 2 will be ensured via a structure process, relying on a contest approach, SME pre-selection, set-up according to a predefined methodology, which relies on ad-hoc tools (and based on 9 criteria) and methodologies, designed with the aim to select only those SMEs with capacity, clear intent and ambition to benefit from the innovation management assessment. In function of the score obtained in the different criteria, the SME will be selected (or not) to benefit from the innovation management capacity assessment held with one of two retained tools, both complaint to EU standard CEN/TS 16555-1 “Innovation management system”. The BENEI2 2020-2021 proposal addresses the obstacles which hinder SME from being more competitive, from growing and creating jobs, thus having a real impact

Keywords: innovation,internationalisation,innovation management capacity,impact,competitiveness,h2020 enhanced european innovation council pilot,funding schemes
Further Understanding Related to Transport limitations at High current density towards future ElectRodes for Fuel Cells (FURTHER-FC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Belgium,Switzerland,France,France,France,France,United States,United Kingdom,Canada
Call: Towards a better understanding of charge, mass and heat transports in new generation PEMFC MEA for automotive applications (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-08-31
Duration (months): 56.0
Total project cost (EUR): 2735031.25
EU funding (EUR): 2199567.35
Participants: 14
Project status: SIGNED

PEMFC is the promising technology for automotive applications with a large deployment horizon by 2030. However, in view of extending their use to a broad range of customers, progress have to be done in terms of cost, performance and durability. The FURTHER-FC project aims at understanding performance limitations due to the coupling between electrochemical and transport issues in the Cathode Catalyst Layer (CCL) which is the main bottleneck for future PEMFC. The comprehensive and innovative approach is based on unique and intensive fundamental characterizations coupled with advanced modelling, from sub-micrometer to its full thickness. The analysis are performed on CCL customized with different and original materials, and will cover structural 3D analysis of the CCL, local operando diagnostics (temperature, liquid water) in the CCL, advanced characterization of ionomer films, innovative diagnostics on transport limitations, fundamental electrochemistry. Advanced one and two-phase models will be used as a support to the experiments and benefit from the experiments for more reliable inputs, physics and validation. The approach will also address the durability issues thanks to the better understanding of the correlation between CCL microstructure, local conditions and properties. FURTHER-FC will propose and validate the performance and durability new ionomer and electrode structures specifically designed to prevent the limitations observed on current MEA, contributing to reach the MAWP targets for horizon 2024-2030. FURTHER-FC will benefit from the active role of renowned partners gathering significant experience on MEA manufacturing and testing (Toyota Europe, CEA, DLR), state-of-the Art experimental techniques (CEA, DLR, PSI, CNRS-IEM, Univ. of Esslingen, Imperial College of London) and modelling tools (CEA, DLR, CNRS-INPT) supported by international entities (Chemours-US, University of Calgary).

Keywords: proton exchange membrane fuel cell,catalyst layer,efficiency,transport issues,multiscale,experiments and models coupling,improved membrane electrode assembly
Gamified and collaborative digital learning open-source platform with a blockchain-based system to facilitate crowdsourced learning and the implementation of personalized education strategies (Social Digital Lab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Social Digital Lab provides a complete set of tools and design assistance to create highly engaging, attractive and gamified learning material, personalized to the learner’s profile. Its user-friendly interface will facilitate a complete edition of the learning material without requiring programming or graphic & game designing skills. It provides tracking and datavisualization tools to check learners’ progressions. Social Digital Lab draws upon game mechanics to enhance learners’ motivation and actively engage them in a learning activity that stimulates collaboration between them. As both a digital learning content hosting platform and a cloud-based SAAS authoring tool, Social Digital Lab allows teachers and trainers all around Europe to create self-paced, gamified, collaborative, on-time learning material. In the e-learning authoring tool landscape, Social Digital Lab is a) trustable thanks to its innovative blockchain-based system for identity and ownership proof & certification; b) user-friendly with a particular care given to the quality of the User eXperience both for authors and learners; c) multi-platform and adapted to every browser, OS and device; d) collaborative and based on socioconstructivism and connectivism to stimulate social learning; e) personalized and adapted to learners’ profiles and objectives.

Keywords: learning,e learning,digital,gamified,game based,open source,blockchain,crowdsourced,serious,game,education,training,gamification,platform,authoring tool,personalized learning
Nanoparticles for Molecular Imaging of Atherosclerosis: from Diagnosis to Treatment (NanoMATe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Atherosclerosis is a disease of the arteries. It leads to the formation of atherosclerotic plaques (atheromas), which may disrupt the blood flow to target organs, leading to heart disease and stroke - the most common causes of death in developed countries. Cardiovascular imaging has traditionally focused on the anatomy of the atherosclerotic plaque; however, the degree of vessel narrowing caused by the plaque isn’t the only characteristic that can determine the clinical outcome. Indeed, the cellular and molecular composition of the atheroma can indicate whether the plaque might cause complications. In particular the local immune-inflammatory response participates from the onset of the pathology through its progression, up to clinical manifestations. Consequently the development of innovative approaches for the molecular imaging of inflammation in atherosclerosis would be key to improve diagnosis and treatment. In the last decade molecular imaging has emerged as a novel tool for the visualization and measurement of biological processes in atheromas. Various imaging technologies have been developed; however, each approach presents severe weaknesses. Surface Enhancement Raman Spectroscopy (SERS) is developing as an effective molecular imaging optical modality in biomedicine because it offers many advantages over traditional technologies, including better sensitivity, and a superior multiplexing capability. Therefore, the primary aim of the present proposal is to develop innovative, highly-sensitive and selective but relatively affordable SERS-based system to measure inflammation in atherosclerotic vessels. I will use nanoparticles (NPs), small metallic particles, which possess the ability to recognise inflammatory markers, as imaging probes. When a light source is shone on these NPs, they can be detected by SERS. The secondary aim is to customise the NPs to enable local treatment of the pathology. The proposed approaches will offer new ways to manage atherosclerosis.

Keywords: atherosclerosis,immune inflammatory response,nanoparticles,surface enhanced raman spectroscopy sers
Advanced Silyl Modified Polymer for the Commercial Transportation and Automotive Elastic Adhesive Markets (Advanced-SiMP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The vehicle assembly and direct-glazing adhesive markets are dominated by Polyurethanes (PU), a high performance technology, in terms of high mechanical strength, high elasticity and durability. Nevertheless, they contain toxic isocyanates making them environmentally unfriendly and require surface preparation and primer for better adhesion upon application. Standard Silyl-modified polymers (SiMP) are being introduced, due to their solvent-free and isocyanate-free nature. However, currently they do not reach the same mechanical properties of PU. Therefore, they mainly find application in After-Market (light weight glasses) and non-structural elastic bonding in transportation. The current situation presents indeed the possibility of a new product that will ensure better mechanical properties than Standard SiMP technology and comparable to PU, environmental and health friendliness and application in a single manner. Our company, NPT, with more than 20 years of experience in the development and production of high performance adhesives and sealants, has been investing the last two years on developing an innovative solution to meet these challenges. Advanced-SiMP will bring to the market the most competitive SiMP solution able to comply with all the technical and mechanical challenges and environmental regulations, offering great performance, no complexity over application and a greener profile. We have identified that if we were to take Advanced-SiMP to mechanical properties of max tensile stress of 6-10 MPa and elongation of ≥200%, we will be able to replace toxic PU in the BTR and OEM market. Moreover, through the completion of this project we expect to reach €12.29 million revenues five years after its commercialization. Phase 2 will require a €1.52 million investment, which will present a Return of Investment of 3.09 in 2023

Keywords: elastic adhesive,polymers,direct glazing,automotive sector
Precise array of proton selective nanopores in 2D atomically thin membranes (NANOPORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Direct methanol fuel cells (DMFCs) are devices expected to power future micro and portable electronic devices as well as vehicles. The lack of efficient proton exchange membranes, however, still prevents the development and application of DMFCs. Of paramount importance is ion selectivity and fast transmembrane transport, for which nanoporous two-dimensional membranes offer the prospect of enhanced fuel cell performance. Several chemical and physical limitations have so far prohibited the wide usage of atomically thin nanopores membranes, most particularly because the process of nanopore formation still lacks a reproducible, scalable and industrially viable fabrication approach. The main goal of this proposal is to develop and finally commercialize such a membrane with precise array of functional nanopores. In this proposal, based on the knowledge and experience resulting from our ERC project [project no. 335879], we will employ a novel two steps approach based on organic and supramolecular chemistry to synthesize atomically thin proton exchange membrane bearing a chemically well-defined array of nanopores and we will control the functionality of the nanopore rim by using specific chemical modifications on the backbones of monomers used to form the high selectivity proton exchange membrane (PEM). If the testing and technical reports are successful, the resulting PEM will be used in DMFC field and other related area, such as desalination and osmosis electricity generation. We strongly believe that this proposal will open a new direction for breaking through the dilemma of the nanopore formation, developing new generation proton selective membranes, as well as promoting the research and applications of DMFC. The proposed work is not only bound to generate great interest from specialists in the field, but also to capture the imagination of the wider public.

Keywords: nanopores,graphene,two dimensional,membrane,fuel cell,proton exchange membrane,dmfc,methanol
Development of a Prophylactic Ebola Vaccine Using an Heterologous Prime-Boost Regimen – Sofia ref.: 115854 (EBOVAC1)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: France,France,Netherlands,United Kingdom,Sierra Leone,United Kingdom
Call: Vaccine development Phase I, II, and III (H2020-JTI-IMI2-2014-02-single-stage, 2014)
Start date: 2014-12-01
End date: 2021-11-30
Duration (months): 84.0
Total project cost (EUR): 98044688.0
EU funding (EUR): 58336885.0
Participants: 7
Project status: CLOSED

The overall aim of the EBOVAC programme is to assess the safety and efficacy of a novel prime boost prophylactic vaccine regimen against Ebola Virus Disease (EVD), which has been 100% effective in preclinical studies. This will be done via phase I, II and III trials carried out in the EU and in Africa, in response to the urgent public health need raised by the current Ebola epidemic. To expedite the development of the vaccine regimen, Phase II and Phase III trials will be carried out in parallel and therefore co-ordinated by two separate teams. Proposals responding to IMI2 Topic 1 will consequently be split into two parts. EBOVAC1 will address the Phase I and Phase III trials, whereas EBOVAC2 will address the Phase II trials. EBOVAC1 will establish the initial safety and immunogenicity of the proposed heterologous prime/ boost regimen of Ad26.ZEBOV and MVA-BNFilo vaccine through phase I studies conducted in the UK, the US and currently Ebola- unaffected African countries. This will be done by administering the vaccine in different sequences and at different time intervals so as to identify the shortest schedule that is immunogenic and to maximize the potential for short term efficacy in affected countries. Initiation of these trials is expected to occur between December 2014 and March 2015 and approximately 300 subjects will be enrolled. The main objective therefore of EBOVAC 2 is to provide extensive and robust data on the safety, immunogenicity and efficacy of the Ad26.ZEBOV and MVA-BN-Filo vaccine. This will be done by: 1. Carrying out translational studies to link vaccine elicited immune responses in humans to protection from Ebola in vaccinated non-human primates (via WP4) 2. Carrying out Phase II trials in African and European volunteers in 6 countries, four in Africa and two in the EU with an overall target enrolment of approximately 1,500 subjects. Given the compressed nature of this development program, the Phase II studies will be conducted in parallel

Keywords: heterologous boost prime ebola vaccine clinical development
Barrel Array Diagnostics And SenSing (BADASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-06-01
End date: 2019-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In array-based sensing, synthetic receptors are appended with chromophores (reporters) and arrayed in various formats. The arrays are treated with analytes that displace the reporter to different extents and the outputs are interpreted by computers to identify the analyte. This has not been demonstrated for arrays of structured de novo designed peptides, which have many advantages over the synthetic small molecules currently used. Through an ERC Advanced Grant, ABEL (340764), we have designed peptides that form novel protein barrels. We have proof of principle results that show that protein barrels can be used for this kind of array sensing. Through this award, we will employ an expert peptide design chemist to address technical issues needed to translate the protein barrels into a technology platform. They will: make and test many variants of the barrels in array formats; establish the best surfaces and attachment chemistries for barrel arrays; and develop algorithms for analysing the outputs. Second, we would employ an expert in biotechnology innovation and management to conduct customer discovery to understand better the market and potential route to exploitation for our technology.

Keywords: array based sensing,biotechnology,coiled coil proteins,colourimetric assay,peptide arrays,protein design,protein engineering,synthetic biology
Causes and consequences of forest reorganization: Towards understanding forest change (FORWARD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1965293.0
EU funding (EUR): 1965293.0
Participants: 1
Project status: SIGNED

Forest ecosystems around the globe are undergoing rapid reorganization. The unabated continuation of climate change, the accelerating rate of alien species introductions, and the precipitous loss of biological diversity are altering the structure and composition of forest ecosystems. As a consequence, novel ecosystems are emerging. However, the trajectories to novelty and the consequences thereof remain widely unknown. This limits the ability of forest policy and management to counteract undesired developments and safeguard the supply of ecosystem services to society. Here I will investigate the causes and consequences of reorganization in forest ecosystems. I will use a concerted combination of complementary methodological approaches to understand why reorganization takes place, when and where reorganization is likely to happen, and what impacts reorganization will have on biodiversity and ecosystem services. Replicated experiments will be conducted both in the field and in walk-in climate chambers to answer whether compounding climatic extremes could result in bottlenecks of forest regeneration. A next-generation forest landscape model will be developed to investigate how invasive alien species alter forest development. Based on these insights the FORWARD project will derive operational early warning indicators of reorganization, and test their generality and applicability in the field for landscapes on three continents. Subsequently, a machine-learning aided synthesis of big datasets will be used to compile the first map of global hotspots of forest reorganization. Finally, robust management strategies for addressing reorganization will be developed. Jointly studying the effects of global change on tree mortality and regeneration across scales, the FORWARD project will bring about a new level of understanding of forest change, and will provide the data, tools and strategies to tackle one of the most pressing challenges of current forest policy and management.

Keywords: forest dynamics,tree mortality,tree regeneration,global change,forest management,tipping points,climatic extremes,early warning