Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Impact of climate change on twilight zone fishes during early-stage development (PLEASE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-03-01
End date: 2025-08-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 2
Project status: SIGNED

Twilight zone (TLZ) hosts the largest and least exploited fish stocks of the world’s oceans. These fishes play a key role in ecosystem services, such as sustaining other relevant marine species and global carbon cycle. The TLZ research is still in its infancy, but the high biomass has raised interest in its exploitation, mainly as fish meal, but also as nutra-pharmaceutical compounds. Moreover, climate change is altering the environmental conditions in ways, of which we do not know how life in TLZ will be affected. It is alarming that this vast ocean domain is at risk even before any of the potential consequences of fishing are fully understood. One of the most threaten and less studied aspects of the TLZ is the early life stage of its fishes. PLEASE project aims to fill this gap of knowledge. The first objective is to set background information about basic biology of the embryonic and larval development of different TLZ fishes. It will be achieved by establishing a suitable methodology for assisted reproductive technology in laboratory conditions, since the wild TLZ fishes are vulnerable to captivity. The reproductive methodology will be transferred to the non-academic partner, for developing pioneered aquarium exhibitions. The second objective is to examine the developmental responses of the embryos and larvae due to ocean warming and acidification under climate change scenarios. It will be monitored via the developmental variability, metabolism, physiology, morphometry, and mortality rates of the specimens. The outcomes of the project will be of paramount importance to forecast the impact of climate change on the community of TLZ fishes and will open a new era for more investigation in this pristine and vulnerable zone of the planet. Finally, a range of interactions with stakeholders and public will ensure the project exploitation and improve the decision-making capacity of the policymakers related with climate change and fishing activities in the TLZ.

Keywords: twilight zone,fish,embryos,larvae,climate change,temperature,acidification
Sensorita - Data driven waste management (Sensorita)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Norway
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Sensorita is developing a cutting-edge radar sensor system to help waste companies better monitor their container fleet. We are combining our hardware sensor, specially designed to endure extreme environments, with our machine learning based software platform to analyze and predict how our customers can automate and streamline waste management and cut costs and emissions. We are targeting construction waste, the largest source to waste in Europe, and large, open waste containers. Sensorita spins out of the sensor and data science community at the Norwegian University of Life Sciences and the technology is based on research of the master’s thesis of the female founder and CEO, Ulrikke Lien. The objectives of this proposal is to strengthen the commercial and organizational aspects of Sensorita. The activities in the work plan are related to activities within sales, organization building and business development. Sensorita's funding so far is linked to the grant from Innovation Norway, which covers our technical development, however succeeding as a deep tech company is a lot more than the technological development.

Keywords: sensor system for waste management,iot,data plattform
Inclusive Artificial Intelligence for Accessible Medical Imaging Across Resource-Limited Settings (AIMIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Spain,Kenya
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2206963.0
EU funding (EUR): 2206963.0
Participants: 2
Project status: SIGNED

Artificial intelligence (AI) is widely regarded as one of the most promising and disruptive technologies for future healthcare. As AI algorithms such as deep neural networks are suited for the processing of large and complex datasets, radiology is the medical speciality that has seen some of the most important applications of AI in the recent years. However, despite these advances, a major limitation of current AI developments in medical imaging is that they have overwhelmingly, and almost entirely, targeted applications in high-income countries. There is a concern, if the current trend continues, that AI will increase the already pronounced inequalities in global health, in particular for resource-limited settings such as rural Africa, where the majority of the African population lives. AIMIX will develop the first scientific framework for inclusive imaging AI in resource-limited settings. The project will greatly advance the current state-of-the-art, from existing AI methods mostly developed for high-income settings, towards new imaging AI algorithms that are fundamentally inclusive, i.e. (1) affordable for resource-limited clinical centres, (2) scalable to under-represented population groups, and (3) accessible to minimally trained clinical workers. Furthermore, AIMIX will investigate the socio-ethical principles and requirements that govern inclusive AI, and examine how they compare, conflict or complement those of trustworthy AI developed thus far in high-income settings. These innovations will be demonstrated for affordable and accessible AI-powered obstetric ultrasound screening by minimally trained clinicians such as midwives in rural Africa. Ultimately, AIMIX’s scientific breakthroughs will enhance the democratisation of imaging AI in resource-limited settings, which will result in an important social impact, by empowering local communities, promoting inclusion, and reducing disparities between populations from low- and high-income societies.

Keywords: inclusive artificial intelligence,affordable medical imaging,low and middle income countries,obstetric ultrasound screening
The Neural Correlates of Object Location Memory (NeuraCOLM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-11-30
Duration (months): 28.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

Remembering where things are, for example, where you parked your car, is essential in everyday life. Without spatial memory, we would continuously be engaged in looking for our car, keys, phone, or glasses. Despite its obvious importance, a lot is still unknown about object location memory (OLM). This proposal aims to uncover mechanisms underlying OLM, specifically taking into consideration the influence of object knowledge on OLM (e.g., if an object is owned or familiar). These factors will be explored by examining individual differences (sex differences and ageing) in WP1, and testing the neural correlates of OLM in WP2. With this aim, the following specific objectives have been established: - Test individual differences in OLM (sex differences and ageing), conducting online studies to understand how o reported sex differences relate to the cognitive mechanisms involved in OLM o ageing affects the cognitive mechanisms involved in OLM - Test how object knowledge (e.g., familiarity and ownership) affects OLM, in fMRI studies we will concurrently acquire neural activation and memory data, to: o Explore the brain areas involved in OLM o Test whether object knowledge effects on OLM are reflected in neural activity of brain areas responsible for the representation of peri-personal (reachable) and extra-personal (out of reach) space. o Test whether neural activation at encoding is predictive of spatial memory error. o Test whether these effects occur upon memory retrieval, or already at the stage of encoding, i.e., during object perception. - Build a Dynamic Causal Model of typical (healthy) OLM, which can be used as a baseline for studies on atypical OLM (e.g., dementia) The results obtained from this multidisciplinary project will be relevant in the fields of gerontology/dementia research, cognitive psychology/ cognitive science, cognitive neuroscience, and neuro-psychology, and will inspire future applications for populations with atypical OLM.

Keywords: spatial cognition memory object location memory neuroimaging
Olfactormativity: Exploring the Intervening Performativity of Smell (OLFAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1739250.0
EU funding (EUR): 1739250.0
Participants: 1
Project status: SIGNED

Smells intervene in human experience. Used by police or military for crowd control, they are a perfidious weapon. Yet, they also offer a wealth of material for intervening arts, the exploration of which is currently gaining traction against a backdrop of climate change and the rise of sexism and racism. So far, however, research on the intervening potential of smell has remained the province of Military Sciences, with research on intervening arts focusing on the visual and the auditory, neglecting the disruptive power of olfaction. OLFAC bridges this gap by, for the first time, exploring the intervening performativity of smell at the intersection of arts and politics. Assuming that odour can be used both to stigmatize and, at the same time, to help “unlearn” socially trained norms, OLFAC will (1) empirically investigate olfactory actors, techniques and technologies applied across performing arts and governmental contexts and (2) develop an integrative, transculturally aligned, and intersectionally oriented theory of Olfactormativity. Fundamentally, the project explores the following questions: How do olfactory techniques and technologies applied in performing arts relate to those used by police and military? What dangers and potential for change do they pose? In what sense are olfactory actors capable of interrupting, subverting or displacing movements of assembly? To what extent can olfactory art break up historically evolved social structures and change perceptual routines? Does the subversive use of odours lead to radical ruptures and changes in terms of gender, class, and ethnicity? Or does it ultimately lead to strengthening conventional concepts of identity? A highly transdisciplinary endeavour, OLFAC draws together approaches and findings from Art-Related Disciplines, Cultural Studies, Anthropology, Psychology, Neurobiology and Chemistry and is set to establish an entirely new playing field for studying the interaction of power, arts, and the senses.

Keywords: smell sensory studies intervening arts olfactory arts arts and politics
Studying the cis-regulatory changes that have shaped human evolution (RegEvoHum)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

While the phenotypes that set us apart from our closest extinct and extant relatives have been largely demarcated, we are still far from understanding the genetics of human adaptation, and how these changes affect our current anatomy, physiology, and health. Most human adaptations have likely occurred in regulatory regions, particularly in cis-regulatory elements, such as promoters and enhancers. However, our ability to study cis-regulatory evolution is limited due to the complexity of identifying cis-regulatory changes and linking them to phenotypes. We believe these limitations can now be tackled by merging several cutting-edge approaches, primarily hybrid cells and massively parallel reporter assays (MPRAs), augmented by developing sorely needed new ones. In Aim 1, we will generate human-ape hybrid cells and use them to identify the gamut of cis-regulatory expression changes separating humans from other apes. In Aim 2, we will perform MPRAs to map the function of each of the variants that distinguish modern humans, Neanderthals, Denisovans and apes. In Aim 3, we will develop methMPRA, a novel method to map the role of DNA methylation in shaping gene expression. In Aim 4, we will synergize these data to study human evolution at the sequence, methylation, expression and phenotypic level. The proposed project will: (a) generate comprehensive resources, including the first catalogs of the sequence and methylation changes that shaped human gene regulation; (b) Develop a novel method to characterize en masse the cis-effects of methylation on expression; (c) Develop novel platforms (human-ape hybrid cells) to map human cis-regulation; and (d) Identify genetic changes underlying human traits. Together, this will pave the way to understanding the role of gene regulation in human evolution.

Keywords: skeletal gene regulation,molecular evolution,noncoding changes,human,archaic humans,neanderthal,denisovan,ape,gene expression,selection,cis regulation,phenotype
iTANK: a nuniversal technology to boost the efficacy of CAR T cell therapies by inducing dual mode-of-actio (CD20CARNAPT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3604499.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Elicera developed a universally compatible technology platform called iTANK (ImmunoTherapies Activated with NAP for efficient Killing) to enhance the efficacy of current and under development CAR-T cell therapies by inducing a dual mechanism-of-action in the treatment of lymphomas and solid tumours. Elicera’s iTANK platform can circumvent major challenges of CAR-T cells in the treatment of solid tumours, such as antigen heterogenicity, local immunosuppression, and CAR T-cell exhaustion. As such, the iTANK platform has a potential to revolutionise the landscape of the immuno-oncology Our innovation arms CAR-T cells with NAP from H.pylori which induces a pro-inflammatory microenvironment and activates the patient’s own CD8+ killer T-cells against the whole repertoire of relevant tumour antigen targets. When tumour cells are killed, NAP-activated dendritic cells can take up tumour-associated antigens and prime killer T-cells against these antigens overcoming problems for CAR-T therapy.

Keywords: dual anticancer action,genetic modification,t cells,immunomodulation,b cell lymphoma,nhl,car t cell therapy
Criminal and state governance in the time of the COVID-19 pandemic: Evidence from Mexico (CovidCrimes)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Hundreds of million people live in areas that are controlled by criminal organized groups (OCGs), suffer from their violent actions, and receive governance from both state and criminal actors. The recent COVID-19 pandemic required governance such as the enforcement of containment restrictions to combat its spread. Notably, during the pandemic, apart from national governments, OCGs engaged in emergency response activities, e.g. delivered aid to people in need or enforced curfews in their controlled territory. The role of criminal governance, particularly in emergencies, is however still largely unknown. CovidCrimes fills this research gap and studies the role of OCGs in emergency response during the COVID-19 pandemic in Mexico. Combining geographical information on the location of OCGs before COVID-19 with performance measures concerning COVID-19 containment policies (excess mortality and COVID-related death rates), CovidCrimes estimates the causal effect of the presence of OCGs on the emergency response performance in a monthly panel of Mexican municipalities using a fixed effects model in combination with several instrumental variable approaches that account for differences in COVID-19 exposure and endogeneity concerns related to the location of OCGs. By gathering novel digital information on criminal and state governance activities at the local level and analyzing their interrelation and effectiveness, CovidCrimes will shed light on the mechanisms how OCGs influence emergency response. Additionally, CovidCrimes will assess the societal consequences of criminal governance by quantifying to what extent OCGs gained power and local support with their emergency response activities. Understanding whether and how OCGs act in emergencies and influence emergency response and its consequences is crucial for the design of effective policies to manage crises and for the stability of political institutions, a core element of a functioning society that is in any case challenged

Keywords: organized crime,criminal and state governance,emergency response,covid 19,applied spatial econometrics
Super-resolution microscopy for semiconductor metrology (MICROSEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Super-resolution microscopy has revolutionized imaging by breaking what was believed to be unbreakable: the diffraction limit – which determines what a microscope can resolve. However, many disciplines in science and engineering cannot benefit from super-resolution microscopy, because practically all current super-resolution microscopes require fluorescence, often introduced by labelling – that is chemically modifying – the samples of interest. The semiconductor industry is the driver of digitization by producing ever smaller integrated circuits for faster computer chips, and has worldwide importance. The critical dimensions of the latest generation of chips are in the nanometer range, enabled by the breakthrough technology of extreme-ultraviolet nanolithography. An efficient production process requires constant quality inspection of the printed features, either directly on the integrated circuits or on dedicated metrology targets. However, the resolution of current all-optical microscopy-based metrology methods cannot keep pace with the fast development of smaller structures by nanolithography. Within my ERC Starting Grant, I demonstrated that high-harmonic generation – that is the frequency upconversion of laser pulses – can be optically suppressed and spatially confined in semiconductors without the need for labelling. This can be utilized as sub-diffraction emission for super-resolution scanning microscopy. I will further develop this technique in MICROSEM in order to reach resolution below 100 nm in a conventional optical microscope operating in the visible and ultraviolet region, without the need of complicated vacuum equipment. This will enable crucial applications for semiconductor wafer metrology. I will demonstrate new in-device metrology, and pave the way for additional advanced at-resolution metrology schemes. To ensure knowledge transfer I enlisted one of the key players in the semiconductor industry as collaborator for MICROSEM.