Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Directional Assembly of Emergent Luminescent and Anisotropic d10 Coinage Metal Organic Chalcogenolate Nanomaterials for Fabrication of Pressure Sensitive Devices (AniMOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2022-09-05
Duration (months): 12.0
Total project cost (EUR): 86466.24
EU funding (EUR): 86466.24
Participants: 1
Project status: CLOSED

Today, there is a tremendous need of new optoelectronic devices for spontaneous and visual reading of the touch/pressure through high-spatial resolution for smart technologies such as e-skin, robotics, touchpad screens, or medical monitors. To replace the Critical Raw Materials (CRM) that actually used in light emissive devices, mostly lanthanides, iridium or platinum, and to generate highly sensitive pressure sensors, the strategy of AniMOC project, is to use luminescent and anisotropic (1D or 2D) nanomaterials, in order to apply a directional strain on the targeted bonds involved in the optoelectronic processes. Thus, the emerging anisotropic d10 coinage Metal Organic Chalcogenolates (MOCs) as coordination polymers, [M(ER)]n, M = Cu, Ag, Au and ER = chalcogenolate ligand, are ideal candidates, because they are a good alternative to CRM and present an intense emission, due to the metallophillic interactions, as well as intrinsic multiemission bands. Therefore, the main breakthrough is to fabricate thin films with a preferential alignment of the anisotropic and luminescent MOCs through strong bonds between the nanoobjects in order to get high pressure sensitivity and stable and reversible processes. To reach this target, the four objectives of AniMOC are (i) to synthesize nanowires and nanosheets of [M(SR)]n, (M = Cu, Ag, Au) (ii) to control the functionalization of the external surfaces of the nanoobjects, (iii) to couple and organize them by cupling reactions dynamc covalent chemistry and (iv) to fabricate orientated thin films of MOCs that exhibit pressure dependent photoemission. The AniMOC project is a great opportunity to develop new luminescent touch sensitive devices that will open a new path to lightening technologies avoiding the present of CRM and provides a better sustainable and economical solution.

Keywords: coordination polymers,coupling reactions,anisotropic materials
Revisiting Europeanization in Southeast Europe. An Historical Approach (RESEE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-12-01
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

The future of Europe will vitally depend on its ability to transform and unify the continent. Southeast Europe, with its complex historical trajectories and its own particularistic Europeanness, has been labelled difficult to Europeanize. Yet, Europeanization in Southeast Europe has a far longer history reaching back into the 19th century and earlier. The main goal of the RESEE project is to establish Europeanization research on the Southeast Europe as a complex historically grounded process, firstly through developing a meaningful narrative integration of the prevailing knowledge in the historical dimension of Europeanization of Southeast Europe; secondly through discussing the usefulness of Europeanization and its related process bringing historical cases of how Europe has influenced Southeast Europe and vice versa; and thirdly through tracing the process back we build an explanatory model that maps the events and actors, the causal mechanisms and factors that interact when a specific historical Europeanization process unfolds in Southeast Europe. RESEE is an innovative project studying a long and much disputed ‘European otherness periphery’ contributing to the rethinking of the region in such a reflexive way that it have meaning and utility in the current EU political project of European Integration. RESEE main academic outputs include a Living Review on the literature, a course proposal and a workshop on the historical dimension of Europeanization on Southeast Europe, a policy paper on best-practices of successful historical cases of Europeanization in Southeast Europe and a number of other dissemination and communication activities. These outputs will attract the attention of academia, policy-makers and also European society since they are a valuable source of scholarly knowledge; they expose high policy relevance to practitioners and they have societal importance in particular to improving citizens perceptions on Southeast Europe and European Integration.

Keywords: europeanization,southeast europe,historical approach,process tracing
Natural Resources and Armed Conflicts under International Law: Rationalizing a Heterogenous Legal Framework (NATRESACIL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-11-01
End date: 2012-10-31
Duration (months): 24.0
Total project cost (EUR): 173270.8
EU funding (EUR): 173270.8
Participants: 2
Project status: CLOSED

The project aims to investigate the relationship between armed conflicts and natural resources under international law. The research begins from the assumption that the linkage between natural resources and armed conflicts is evident and multi-faceted in nature. It can be analyzed from four different perspectives. In their relationship with armed conflicts natural resources can be: a) A concomitant cause; b) An object of the destruction brought about by the hostilities; c) An object of the exploitative activities during the occupation phase; d) A factor inducing a change in the political and economic order of the (occupied) territories and the States. After having broached some preliminary issues concerning the definition of natural resources, the project will engage with the international rules and principles that are applicable to the phenomena described above. The analysis will consider the rules regulating access to natural resources in the pre-conflict phase; the rules protecting the resources pending the conflict; the rules regulating the exploitation, the ownership, and the legal regime of the resources during and after the occupation. Different bodies of rules such as the law on the use of armed force, the law of war and the law of occupation, international environmental law, international commercial law, human rights law and permanent sovereignty over natural resources will be investigated. The ultimate objective of the project is to identify the antinomies and understand the interaction between the relevant legal regimes. Another objective lies in applying a coherent set of interpretive and systemic tools with the aim of reducing fragmentation and inconsistencies. The research method will make reference to the sources of international law and to the practice of the relevant subjects. The Israeli-Palestinian question, Iraq, East Timor, the RDC, Sierra Leone, and Western Sahara are among the case studies.

Keywords: natural resources,armed conflicts,international law,international humanitarian law,permanent sovereignty,human rights,international environmental law,use of force
Extended studies into the molecular pathogenesis of Congenital Adrenal Hyperplasia - towards novel therapeutic approaches (ADRENAL ENZYMES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

Congenital Adrenal Hyperplasia (CAH) ranks amongst the most common inherited metabolic diseases. It comprises a group of autosomal recessive disorders caused by mutations in genes encoding enzymes involved in steroid synthesis. Two key enzymes are the cytochrome P450 (CYP) type II enzymes 21-hydroxylase (CYP21A2) and 17α-hydroxylase (CYP17A1), both requiring electron transfer from the electron donor enzyme P450 oxidoreductase (POR). Functional analysis of CAH-causing mutations currently consists only of in vitro enzyme activity assays that do not address other and potentially very important molecular aspects such as protein folding and enzyme-cofactor dimerisation. Incorrect protein folding may lead to endoplasmic reticulum (ER) stress, which plays an important role in the pathogenesis of various diseases, e.g. diabetes mellitus. The first aim of the proposed project is to systematically analyse mutations in CYP21A2, CYP17A1 and POR by not only studying residual in vitro activity, but also by dissecting the mutations’ effects on protein stability and protein degradation. Subsequent studies will establish the potentially therapeutic role of small molecules (pharmacological chaperones, proteostasis regulators) in refolding and restoration of enzyme function of CYP21A2, CYP17A1 and POR enzymes. Secondly, this project will characterise the ER localisation and interactions of the CYP21A2, CYP17A1 and POR proteins, including dimer-formation. These data will provide essential insights into functional and structural in vivo topology of steroidogenic enzymes. This will lead to a better understanding of molecular mechanisms involved in steroidogenesis. In conclusion, this highly innovative project will apply novel strategies to study and to potentially restore steroidogenic enzyme function. The proposed studies will hopefully pave for a novel molecular tailored therapy and in addition they provide an ideal advanced training platform.

Keywords: health sciences,disordered sex differentiation,congenital adrenal hyperplasia,endoplasmic reticulum,protein interaction,21-hydroxylase,cyp21a2,17a-hydroxylase,cyp17a1,p450 oxidoreductase,por
NEUROanatomy, neurochemistry and genotype: genetic diversity and division of labour in leaf-cutting ANTs (NEUROANT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-10
End date: 2013-01-09
Duration (months): 24.0
Total project cost (EUR): 240289.6
EU funding (EUR): 240289.6
Participants: 1
Project status: CLOSED

The discovery and characterizations of neuromechanisms that mediate the genotypic changes in behaviour is a premier paradigm in biology today. The difficulty in finding defined answers rests in the multiplication of confounding factors (environment, individual behavioural flexibility, genotypic variation and polygenetic traits) and the limited sample size for comparison. This project will use social insect colonies to overcome these issues to answer this question. The project will use the leaf-cutting ant, Acromrymex echinatior, as the model species because this ant has recently been shown to exhibit genetic influences on caste specialization, has colonies headed by single queens mated to multiple males, thus producing genetically diverse offspring, and has colony sizes that will produce numerous individuals from each paternal line. Therefore, ants from a single colony share a common environment, the same maternal genotype on average but can differ in their paternal genotype, and are behaviourally specialized. We will use molecular techniques to characterize the genotypic variations among behaviourally specialized ants of different patrilines from single colonies. We will combine this with testing whether there are neuroanatomical and neurochemical differences between these ants to establish the neuromechanisms underpinning genetic variation in division of labour. Ant brains will be assayed utilizing serial sectioning at the light and electron microscopy levels for brain morphology and immunocytochemistry, visualized with laser confocal microscopy and HPLC for direct measurement for biogenic amine analysis. This study will provide answers to the neuromechanisms governing genotypically derived behaviours.

Keywords: sociobiology,social insect,ant brain,polyethism,biogenic amine
Territorial politics in Ukraine during transition from authoritarian rule (TERRITORIAL POLITICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-09-13
End date: 2012-09-12
Duration (months): 24.0
Total project cost (EUR): 164040.8
EU funding (EUR): 164040.8
Participants: 1
Project status: CLOSED

This project is aimed at studying the interconnection between territorial politics and democratization processes in Ukraine. The project will bring new knowledge on this crucial EU partner and uncover a huge explanatory potential of territorial politics in Ukraine by studying the changes in distribution of political and economic power between national and sub-state levels, sub-state territorial politics, and territorial strategies across the country. The research will seek to apply theoretical insights and methodological tools of the Western European / North American tradition of studying territorial politics to complement work in the post-Soviet studies tradition on democratic practices in Ukraine. Conducting research through a territory-centred prism of analysis will complement the vision of democratization, which is provided by a state-centred approach of the field of post-Soviet studies. This will contribute to a broader understanding of democratization processes and generate new ideas on how democratic transformation is driven from sub-state levels. The project will use quantitative and qualitative research methods. The knowledge transfer strategy of the project includes presenting its results at informal series of seminars at the Institute of Governance, preparing two conference papers and two journal articles, organization of an international workshop on territorial politics in Eastern and Western Europe and presenting its results as an edited volume, and preparing an academic course “Territorial Politics of Ukraine in Comparative Perspective”. Also, the added value of this research will go beyond academia. The project will create favorable conditions for long-lasting cooperation of European and Ukrainian experts on sub-state democratic processes.

Keywords: territorial politics,democratization,ukraine
Framing the World: Genre as Worldview (FWGW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-11-15
End date: 2013-11-14
Duration (months): 24.0
Total project cost (EUR): 160835.2
EU funding (EUR): 160835.2
Participants: 2
Project status: CLOSED

The problem of worldview in cognitive science concerns how high-level conceptual structures govern lower-level interpretation, emotion, reasoning, and discourse. Due to this top-down influence, when worldviews conflict people often literally cannot understand the “other side,” and may attribute their beliefs and values to non-cognitive causes (personal interest, conformity, ignorance). “Culture wars” arise when moral-political worldviews compete. Thus the study of worldview is central for communication and social dynamics as well as individual cognition. Research on the role of the body, emotion, and imagination in thought and language has led to a “second cognitive revolution.” Metaphor and narrative are now recognized as core cognitive structures. An influential linguistic analysis sees the contrast between political worldviews as based on models of the ideal family, which get applied metaphorically to the nation. Liberalism has a “nurturant parent” model, conservatism a “strict father” model. However, while the role of metaphor in worldview has been studied extensively, the role of narrative has been overlooked. Further, the fundamental links between metaphor and narrative in discourse are only beginning to be studied. I will contribute to this research by developing models of two further worldview structures. First, I will develop contrasting models of the body as a moral ideal (flexible and open vs. strong and rigid), and as a political metaphor (the Body Politic). Second, I will develop contrasting models of basic story types, or genres—comedy and tragedy—as sources of structure for key event-concepts in moral-political domains: concepts of the origins, course, and destiny of human life, the family, society, and the world. I will develop and refine my models in the light of the texts that first formulated modern liberalism and conservatism: the political discourses of Hobbes, Locke, Rousseau, Smith, Burke, Godwin, Wollstonecraft, Paine, and Malthus.

Keywords: english literature,semiotics,rhetoric,literary criticism,cognitive science,psycholinguistics,moral philosophy
WIreless SEnsoR Networks for cognitivE sofTware radioS (WISERNETS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 153917.0
EU funding (EUR): 153917.0
Participants: 1
Project status: CLOSED

Many spectrum measurements have evidenced great temporal and geographical variability in the usage of licensed spectral bands. In conjunction with fixed spectrum assignment policies and the limited amount of available radio spectrum, this results in low efficiency in the use of this scarce resource. Cognitive radios provided with Dynamic Spectrum Access (DSA) capabilities will improve this situation by granting unlicensed 'secondary' networks access to licensed bands in an opportunistic manner, as long as interference with licensed 'primary' networks is kept at tolerable levels. The capability to detect spectrum holes, without interfering with the primary network currently in use, is one the actual major difficulty faced by the cognitive radio, all the more as a fine granularity of allocation (time and frequency) is targeted. WISERNETS project will focus on developing innovative techniques based on wireless sensor networks to perform the sensing of the cognitive radios, supporting the coexistence of licensed primary and unlicensed secondary wireless users in a same area, analyzing also fundamental limits of performance using sofware defined radio terminals. This technology will allow addressing a very dynamic and competitive mixed radio access between cellular and broadband technologies. The sensor network aided cognitive radio proposed and studied in this project will address several objectives, including: a) novel spectrum distributed sensing techniques to be able to identify spectrum holes, b) corresponding information management and exploitation to achieve the co-existence of cognitive secondary radios with primary licensed technology, without generating harmful interferences. The project will integrate a wireless sensor network for cognitive radio with sofware defined radio terminals to emulate primary and secondary users. This demonstrator will be used to evaluate the performance of the proposed architecture.

Keywords: telecommunications engineering,cognitive radio,wireless sensor networks,dynamic spectrum access,software defined radio
The Molecular Basis of Mitochondrial Disease: Elucidating the Function of the Mitochondrial Inner Membrane Protein MPV17 (MDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 231427.2
EU funding (EUR): 231427.2
Participants: 1
Project status: CLOSED

Mitochondria contain their own DNA (mtDNA), which contributes essential components of the energy generating system of the organelle. Because mtDNA requires many nuclear gene products for its maintenance and expression, nuclear gene defects can lead to mtDNA loss. MPV17 is one such gene, pathological mutations in MPV17 were identified by the researcher as a cause of mtDNA loss, yet the function of the protein remains obscure. The primary aim of the project is to elucidate the function of MPV17p, in order to understand how mutations in this gene cause mtDNA loss and human pathology. Specific aims are: i) to affinity-purify tagged versions of MPV17p from human cultured cells with the aim of identifying partner proteins. ii) To characterize the protein components of the different molecular weight complexes that contain MPV17p, using native electrophoresis. iii) To determine the effects of modulating the expression of MPV17p upon mitochondrial function and mtDNA integrity and stability in human cells, using an inducible expression system. iv) To harvest correctly folded and functional recombinant MPV17p from bacterial membranes for in vitro experiments and structural biology studies. The new information is expected to provide further insights into mitochondrial diseases and to yield fundamental knowledge of the mitochondrion. It is anticipated that the advance in knowledge will have implications for disorders of mitochondrial DNA maintenance in general, not only those related directly to mutations in MPV17.

Keywords: health sciences,natural sciences