Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart wearables for tailored health and exercise assessment of real-time training (SWEATHEART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

In the context of the EU "Healthier Together" initiative, the main objectives include reducing the significant health burden of Non-Communicable Diseases (NCDs), especially cardiorespiratory (CR) ones, and improving the overall health and well-being of the community. As several CR diseases manifest during extreme exercise, there is a need to monitor these conditions and tailor the exercise regimens to the specific subject’s CR profile. The goal of SWEATHEART is to create an energy-efficient embedded wearable system to continuously monitor CR parameters during high-intensity exercise and exercise-induced phenomena in elite athletes, whose profile is the most suited. It will use accurate wearable sensors in real-world training sessions to tailor exercise prescriptions and prevent overreaching and cardiorespiratory issues. To achieve the goal, SWEATHEART will follow three objectives: 1) Detect the CR parameters in real-time using an optimal set of non-invasive and low-cost wearable sensors and emerging computing techniques; 2) Detect fatigue and overreaching derived by extreme exercise based on the extracted CR parameters; 3) Design an energy-efficient embedded system for tailored exercise prescription based on the CR parameters and overreaching. The project requires multidisciplinary involvement of different parties. The host institution and the supervisor have extensive knowledge of mathematical and statistical modeling and machine learning methodologies. Moreover, their collaborations with sports clubs and the supervisor's start-up experience will enhance the project results and the researchers's future career development. The secondment institution specializes in exercise physiology and has long-lasting experience in data protocol design. The applicant contributes to the system-level design of embedded wearable sensors for biomedical applications. The hosts and applicant will mutually benefit from the project outcomes and the newly formed collaborations.

Keywords: biomedical wearable sensors,tailored exercise prescription,online cardiorespiratory monitoring,ventilatory thresholds,energy efficient embedded computing,overreaching prevention
Quantum Technologies Accelerating Stochastic Tasks (Q-TASTic)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 2802936.63
EU funding (EUR): 1962055.64
Participants: 1
Project status: SIGNED

Quantum Dice is pioneering Q-TASTic, the world’s first probabilistic processor, integrating quantum photonic randomness with stochastic computing to unlock unparalleled efficiency in AI, optimisation, and scientific modelling. Current deterministic computing architectures struggle with probabilistic tasks, relying on pseudorandom number generators (PRNGs) that introduce inefficiencies and energy waste. Q-TASTic overcomes these limitations by leveraging true quantum randomness, enabling faster, more energy-efficient solutions. The project aims to scale up Quantum Dice’s TRL6 prototype to TRL8, developing a fully functional probabilistic computing platform. Key advancements include a universal architecture for stochastic tasks, an optimised compiler, and a scalable cloud-based deployment model. By combining hardware-accelerated randomness generation with a flexible computational framework, Q-TASTic will deliver 10x energy savings and 10x speed improvements over classical approaches. The impact is broad: AI inference, logistics optimisation, climate modelling, drug discovery, and financial risk analysis will all benefit from improved computational efficiency. Q-TASTic aligns with the EU’s Digital Decade Strategy, AI Act, and energy efficiency goals, contributing to Europe’s leadership in high-performance computing. With strong backing from investors, industry leaders, and research institutions, Q-TASTic is set to revolutionise next-generation computing while fostering technological sovereignty and sustainability.

Keywords: next gen computing,high performance computing,probabilistic computing,stochastic modelling
BARIN SPORTS' SMART TEXTILE - THE FUTURE OF SPORTS AND HEALTH (Barin Smart Textile)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Bulgaria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 1
Project status: SIGNED

We are Barin Sports AD – an innovative Bulgarian company with a passion to bridge the gap between wearables and smart textiles. The goal of our project is to revolutionize health monitoring for athletes, fitness enthusiasts and individuals engage in physical activity by developing Barin Sports' Smart Textile – a ground-breaking innovation that allows real-time monitoring of vital parameters with medical precision and has the potential to completely change the healthcare monitoring. Barin Sports' Smart Textile is designed to seamlessly integrate advanced health monitoring capabilities into everyday clothing, providing real-time data and insights to users and healthcare providers. Barin Sports' Smart Textile is a high potential innovation that is already at an advanced stage of technological development – TRL 5. We apply for the EIC grant funding to complete the following key activities within the next 24 months: R&D: Further development and finalization of our smart textile technology that ensure seamless and non-intrusive monitoring that performs reliably under the most challenging conditions. Production Scale-Up and Market Expansion: we will secure robust Intellectual Property Rights to protect our innovation, ensuring freedom to operate and a strong competitive position in the rapidly expanding smart textile market. The innovation is backed by a team of Barin Sports' experts united by a shared vision - to lead the evolution of wearable technology into the era of smart textiles and beyond. Our gender-balanced team includes specialists with extensive experience across all areas crucial to this innovation— textile-based ECG sensors, flexible electrodes, battery, electrocardiography (ECG), IT, data transfer, business development, and finance. This team will ensure not only the successful implementation of the project but also its impact and lasting success in the market.

Keywords: smart textile sports healthcare monitoring wellbeing electrocardiography ecg textile based ecg sensors
COLFIN: Colonial Financial Infrastructures (COLFIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-08-01
End date: 2031-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

COLFIN develops a new approach to understanding and responding to the colonial durabilities in modern financial infrastructures. The starting point is that the relation between finance and colonialism is infrastructural, not purely related to individual families or companies. Financial innovation co-evolved with colonial expansion and vice versa. The longer time horizons, transnational payments and novel uncertainties of colonial expansion are at the heart of modern financial innovation. Academic literatures acknowledge this but largely write colonial violence out of the history of finance. The aim of COLFIN is to understand and analyse how the experimental beginnings and development of financial instruments were shaped by and through colonial exploitation and appropriation. The novel approach is to focus on financial infrastructures, understood as socio-technical and historically durable ways of organizing political-economic life. The key question of COLFIN is: How are modern financial infrastructures, including credit, currency and collateral, shaped by and through colonial practices of exploitation and appropriation? COLFIN focuses on four infrastructural elements: (1) material technologies; (2) circulation; (3) adverse inclusion; (4) practices of temporality. COLFIN breaks new ground because (1) it offers systemic analysis of a largely neglected part of the history of political economy and finance; (2) it shows how present financial infrastructures indirectly entail refashioned colonial practices and routes. It is urgent because it reconnects the account of financial innovation to the history of colonial exploitation, to generate new avenues of accountability in the present. It is feasible because of the availability of newly digitized archives of early modern public-private colonial companies including the Dutch and British East India Companies. COLFIN develops new methodological approaches to digitized colonial archives, while being attentive to their silences

Keywords: financial infrastructure,postcolonialism,colonial durability,postcolonial international political economy,politics of finance,infrastructure studies,international political sociology,racialized political economy
Reprogramming eNdOthelial cells in immune-COLD tuMORs (noCOLDmore)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Lung cancer is the leading cause of cancer-related deaths worldwide. Currently, immunotherapy (IT) is the standard of care for the treatment of some subtypes, with only nominal success. IT works best in inflamed “hot” tumors and is often ineffective in immune cell-desert “cold” tumors. In KRAS-mutated lung adenocarcinoma -LUAD, the most frequent type of lung cancer- the presence of a mutation in the STK11/LKB1 gene is linked to a cold tumor, while the co-occurrence of a TP53 mutation corresponds to a hot tumor. Amongst different cell types in the tumor environment impacting immune cell composition, endothelial cells (ECs) present an important and often overlooked modulator of immune profiles. Previous research has identified immunoregulatory genes expressed by ECs and proposed immuno-modulatory roles of ECs. I hypothesize that specific mutations cause the expression of immunosuppressive genes by ECs, which might explain the association of gene mutations affecting the immune environment. Thus, modulating ECs to reprogram them into immunostimulatory phenotypes in the immune cold tumors, could present a promising strategy to improve IT responses. To identify the immunosuppressive gene signature in ECs in immune cold vs hot tumors, I will utilize transgenic mouse models of LUAD: KrasG12D/+; Lkb1flox/flox (KL) and KrasG12D/+; Tp53flox/flox (KP) mice. First, using scRNAseq, I will establish an EC signature linked to the immune cold tumors and subsequently to identify EC-specific candidate immunosuppressive targets. After that, I will use state-of-the-art technologies that enable efficient gene targeting to validate the discovered targets in KL mice. I perform multidisciplinary approaches to delineate the molecular mode of action of the target exhibiting a substantial therapeutic effect in mice and overcoming the resistance to current anti-cancer IT. Finally, I will employ a humanized orthotopic lung PDX mouse model to further validate and test therapeutic opportunities.

Keywords: lung cancer,immune cold tumours,immunosuppresive genes,endothelial cells,immunomodulation,immunotherapy resistance
Health Risks to Amazon Women and Adaptation of Riverine Communities to Dry Hazards (HER-AWARD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 3
Project status: SIGNED

The Amazon River Basin is under threat due to climate change, deforestation, and forest fire. Hydroclimatic records show an increase in both the duration and intensity of droughts with remarkable events occurring in the past 20 years in the region. Climate projections indicate overall drier conditions for most of the Amazon in the next decades, together with a higher frequency of extremes such as droughts and floods. By means of positive feedback between climate change and deforestation, changes in precipitation, evapotranspiration, and air temperature exacerbate extreme droughts, which frequently co-occurs with heatwaves and forest fires, the three of them being referred to as dry hazards. Compound dry hazards pose health impacts that can be felt differently according to gender, with increasing evidence suggesting that women suffer more intensively because of social norms regarding gender roles as well as due to physiological factors related to reproductive health. HER-AWARD (Health Risks to Amazon Women and Adaptation of Riverine Communities to Dry Hazards) is an interdisciplinary research project aimed to elucidate the intersectional dimensions of health risks associated with dry hazards among women from riverine communities of the BR Amazon. The project seeks to understand the overlapping impacts of compound dry hazards and their cascading effects on women's health. The research is organized into primary components that explore two different spatial scales: starting from a basin-wide perspective and zooming in to a community level. By integrating these scopes, HER-AWARD aims to generate actionable insights and inform effective interventions tailored to the unique needs of riverine women in the Amazon, grounded on scientific and local knowledge through a gender lens. The project is based on an interdisciplinary methodology, combining large-scale environmental modelling, hydrological and spatial analysis, as well as case study social science methods.

Keywords: climate change drought tropical forest river basin freshwater traditional communities indigenous and local knowledge navigation hydrology heatwaves fire deforestation
Transposable Elements as Architects Shaping Embryonic development (TEASEr)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1500328.0
EU funding (EUR): 1500328.0
Participants: 1
Project status: SIGNED

The formation of a functional embryo is dictated by precise genetic and morphogenetic events. Yet, focusing solely on gene expression does not seem sufficient to explain all developmental phenotypes. Mobile genetic elements (or transposable elements, TEs) have been little studied in the context of cellular differentiation and organogenesis. I propose that TEs contribute to embryo formation, both in physiological and pathological contexts. Nearly all eukaryotic genomes contain TEs, which account for roughly half of the mammalian genome. TEs are involved in early pre-implantation development as well as pathologies such as cancer and aging, but their role in the post-implantation embryo is unclear. This is in part due to technical challenges that can now be overcome with advances in genome engineering and long-read sequencing. I recently described that the aberrant expression of a TE during mouse limb development leads to the production of toxic viral-like particles (VLPs), causing a pathological phenotype. Mechanistically, this involves the TE using local gene regulation for its own transcription in specific developmental cells. These findings provoke emerging concepts on how TEs can disrupt or participate in embryo formation which will be addressed in this proposal through the generation of tailored stem cell and in vivo mouse models targeting specific TEs, combined with high-throughput sequencing and microscopy. First, I will investigate the pathogenic threat of TE insertion in mouse embryos during organogenesis. Second, the silencing and activation of TEs during lineage commitment will be addressed in stem-cell-based embryo models. Finally, I will explore the role of TEs in tissue shaping during developmental senescence. This will provide novel insight into unexplored areas of genomic regulation during embryo development. Thereby, TEASEr will introduce TEs as an important player in genetic unsolved congenital malformation and physiological embryogenesis.

Keywords: transposable elements,development,mouse embryogenesis,genomics
Genetic factors Enabling Microbiome Symbioses: Bees as a natural model system (BEE_GEMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1498125.0
EU funding (EUR): 1498125.0
Participants: 2
Project status: SIGNED

The gut microbiome is essential for the wellbeing of many animals including humans and bees. However, the genetic factors that enable stable, healthy microbiomes remain poorly understood. In particular, little is known about how different members of a gut microbial community communicate and interact with one another, both at the molecular level (which genes underlie the interactions) and the ecological level (how these genes are distributed across populations). Due to the complexity of most gut microbiomes, previous work in this field has largely been limited to in vitro studies using simplified, synthetic communities. In contrast, the core aim of this project is a systematic analysis of microbial interaction mechanisms at both the molecular and ecological levels. Unlike other systems, we can culture all members of the bee gut microbiome and have recently developed genetic tools for their manipulation. I will leverage these unique advantages, together with my expertise in social bees (honey bees, bumble bees) and microbial genetics, in an integrative approach to fulfil the project objectives. Work Package 1 will reveal the genes underlying pairwise intermicrobial interactions though unbiased in vitro and in vivo transcriptomics and proteomics. These genes, together with candidates I previously identified (secretion systems and toxin genes), will be investigated in detail using genetic and biochemical methods to uncover their mechanisms of action and novel functions. Work Package 2 will clarify how these interactions play out across populations by assessing variation of interaction genes with ecological factors (geography, host background), and by probing the evolutionary forces that lead to these variations. Our findings will contribute empirically to identifying the general principles behind microbiome assembly and function, which has broad implications across all fields where microbiomes play important roles including in agriculture, medicine, and biotechnology.

Keywords: microbiology,entomology
Risk and resilience in adolescent decision-making (DeMARRe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Adolescents take more risks than adults do, contributing to the conventional framing of this period as one of great vulnerability. Surprisingly however, teenagers who engage in some degree of risk-taking exhibit more favorable psychosocial trajectories compared to those who avoid risks. This raises the intriguing possibility that taking risks during adolescence may, in fact, have enduring positive effects on adult behavior. The core objective of this proposal is to unravel the neural basis of how taking risks during adolescence can drive behavioral and neural circuit adaptations that promote resilience in adulthood. Risk-taking behavior can be studied in the context of decision making, where adolescents are more likely to explore risky choices, such as those with an uncertain outcome, than adults are. Strategy implementation under uncertainty conditions in adults is highly individualistic and is linked to activity in the dopamine system. As dopamine circuits develop during adolescence in a sex-specific manner, their maturation may contribute not only to the reduction in risk-taking observed between adolescence and adulthood, but also to sex differences in how risk modulates decision-making strategy. Finally, dopamine circuits may carry a neural imprint of the enduring positive effects on adult behavior. Here, I propose a concerted, multilevel experimental approach that builds from longitudinal behavioral and computational analyses of individualistic mouse decision-making across postnatal life in male and female mice. Embedding this core framework within sophisticated activity-mapping and network-manipulation techniques will allow me to dissect changes in dopaminergic networks during the transition from adolescence to adulthood that underlie decision-making strategy refinement, and to investigate whether this network refinement facilitates cognitive processes in adults, and, in turn, confers resilience against drug-taking and stress.

Keywords: adolescence,decision making,exploration,dopamine,resilience,functional networks