Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromosome number variations in vivo: probing mechanisms of genesis and elimination (CHROMONUMBER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

How variations in whole chromosome number impact organism homeostasis remains an open question. Variations to the normal euploid genome content are frequently found in healthy animals and are thought to contribute with phenotypic variability in adverse situations. Yet they are also at the basis of several human diseases, including neuro-developmental disorders and cancer. Our preliminary data shows that physiological aneuploidy can be identified in certain cells during development. Moreover, we have observed that when induced through mutations, non-euploid cells are effectively eliminated from the cycling population. A quantitative view of the frequency of non-euploid karyotypes and the mechanisms underlying their genesis is lacking in the literature. Further, the tissue specific responses at play to eliminate non-euploid cells, when induced through mutations are not understood. The objectives of this proposal are to quantitatively assess the occurrence of physiological chromosome number variations gaining insight into mechanisms involved in generating it. Additionally, we will identify the tissue-specific pathways involved in maintaining organism homeostasis through the elimination of non-euploid cells. We will use a novel genetic approach to monitor individual chromosome loss at the level of the entire organism, combine it with quantitative methods and state-of-the art-microscopy, and focus on two model organisms - Drosophila and mouse - during development and adulthood. We predict that the findings resulting from this proposal will significantly impact the fields of cell, developmental and animal physiology, generating novel concepts that will bridge the existing gaps in the field, and expand our understanding of the links between karyotype variations, animal development and disease establishment.

Keywords: aneuploidy,polyploidy,cell death,premature differentiation,stem cells,epithelial cells,tissue dependent responses,microcephaly,cancer
Establishing a European Knowledge and Learning Mechanism to Improve the Policy-Science-Society Interface on Biodiversity and Ecosystem Services (EKLIPSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Coordination and support actions
Countries involved: Germany,Germany,Belgium,Finland,Romania,Hungary,France,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: An EU support mechanism for evidence-based policy on biodiversity & ecosystems services (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2022-09-30
Duration (months): 80.0
Total project cost (EUR): 3117272.49
EU funding (EUR): 3117270.99
Participants: 13
Project status: CLOSED

The aim of EKLIPSE is to establish an innovative, light, self-sustainable EU support mechanism for evidence-based policy on biodiversity and ecosystems services open to all relevant knowledge holders and users, and to hand over this mechanism to the wider knowledge community by the end of the project. The mechanism will build on existing science-policy-society interfaces and be further refined via iterative evaluation and learning throughout the project. The mechanism will provide trustworthy evidence for policy and society upon request and will make the knowledge community more able to provide synthesized and timely evidence by providing a platform for mutual learning and engagement. All relevant knowledge holders and users will be actively encouraged and supported by the project team through their individual strengths and interests, thus ensuring targeted contributions. Many institutions have already expressed their interest in the “Network of Networks” of potential contributors to the EU mechanism’s activities. EKLIPSE will directly support the further development of this network and ensure the involvement of relevant stakeholders in the following key areas: (a) jointly developing and setting up a business plan for the mechanism after the end of the project (WP1), (b) conducting joint evidence assessments using established and innovative methods to support policy and societal needs (WP3), (c) jointly identifying research needs and emerging issues (WP4), actively building the Network of Networks and (d) encouraging societal engagement (WP6). This will be supported by an interim governance structure, a strong communication component, including a Science-Policy-Society Forum, and an independent formative evaluation to ensure learning (WP2).

Keywords: support for evidence based policy,science society policy interface,network of knowledge,development of governance structure,biodiversity and ecosystems services,co synthesised evidence
Optogenetic control of leader cell mechanobiology during collective cell migration (OPTOLEADER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Emergent collective behaviours such as flocks and waves are a hallmark of biological active matter, and occur prominently also in large groups of migrating epithelial cells, where they are involved in fundamental biological processes such as wound healing, morphogenesis and cancer cell invasion. Physical forces transduced between cells and arising between cells and the extracellular matrix (ECM) play an integral role in orchestrated multicellular phenomena. Another integral contribution is given by the actions of leader cells, that modulate and guide the migration of cohesive cell groups. How leader cells achieve this using intracellular and cell-ECM forces remains largely to be understood. Here we propose an experimental approach to generate leader cells using optogenetics and to study how leaders influence the collective behaviour of migratory cell groups. We will use epithelial cells expressing light-sensitive activators of RhoGTPases, which enable reversible and directional control of cell motility using blue light. Traction force microscopy and monolayer stress microscopy will be performed using these cells while we will create and control leaders. With functionalized substrates, we will study the mechanical role of leaders in different conditions, from confined two-cell systems to confluent monolayers exhibiting flocking. Finally, we will express the light-sensitive proteins in cancer cells, to study how their three-dimensional dissemination is affected by leaders. Our experimental approach combines physics-derived modelling and quantification of forces with advanced molecular biology tools. The latter will enable us to perform selected modifications on cells, targeting a wide array of proteins involved in cell-cell adhesion and force transduction. Our goal is to shed light on how leaders physically influence collective migration in physiologically relevant situations, paving the way for the in vivo applications of light-induced leader cells.
ACTIONABLE BUSINESS INTELLIGENCE UPON POPULATION MOBILITY PATTERNS ANALYSIS (DEMOGRAPHICA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain,Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 2039120.0
EU funding (EUR): 1427384.0
Participants: 2
Project status: CLOSED

What if an algorithm could analyse collective human behaviour and produce per-location, per-time-frame, actionable and reliable predictions fully customised as per each clients’ market needs? This would benefit all those verticals that depend on mobility patterns to plan effective actions. Marketers would count with tools to design efficient and viral advertising, awareness or fundraising campaigns. Smart- cities/Municipalities’ mobility and tourism responsibles would count with scientific tools to effectively put into practice their politics. Toll-roads planners/managers would count with reliable tools to manage actions. DEMOGRAPHICA makes use of socio-thermodynamics to analyse the complex, massive and anonymised data (i.e. Call Detail Records -CDR-) provided by Mobile Network Operators (MNOs) to forecast mobility patterns of general population. This allows us to understand and reliably forecast citizens’ mobility patterns without violating their privacy. This is useful in many verticals where understanding these mobility patterns is essential to drive informed decisions and improve different KPIs (key performance indicators), from profitability to service level, especially in the whole world of smartcities, and particularly in some niches of this big market such as Transportation, Tourism and Out-of-Home Marketing, but it also has application in other sectors such as Health (epidemics evolution prediction), energy or cybersecurity, to mention a few.

Keywords: social physics,socio thermodynamics,population mobility,big data,smart cities,tourism,marketing,transportation
Spatio-functional cellular interplay in peripheral nerve diseases (AxoMyoGlia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1492175.0
EU funding (EUR): 1492175.0
Participants: 1
Project status: SIGNED

Neuromuscular disorders belong to the most common but least treatable neurological conditions and are caused by defects in cell types that together build the neuromuscular unit – motoneurons and their axons, glial cells and myocytes. Clinically, neuromuscular diseases share an impairment of motor function and the intimate functional relationship of involved cell types suggests overlapping pathological mechanisms. As our current understanding is largely confined to locally isolated processes, the present AxoMyoGlia proposal will undertake the ambitious approach to elucidate the spatial dimensions of the molecular interplay among the key cellular players of the neuromuscular unit. By taking demyelinating peripheral neuropathies as a powerful model system, I aim at unravelling basic principles of how local glial impairment propagates malfunction within the neuromuscular unit, including potential remote axon and muscle feedback mechanisms. To this end, I will employ neuropathic mouse models and generate a holistic transcriptional cellular interactome of the diseased neuromuscular unit at single cell resolution level. With milli- to nanometer imaging precision, this interactome will be extended to the first visualization of the spatial relation between glial and axonal dysfunction along the entire longitudinal dimension of the nerve. In order to untangle local and distant causes from consequences, I will develop an innovative mouse model that will offer the unprecedented option to specifically induce and examine the global consequences of locally restricted glial neuropathy at any position in the neuromuscular system. With its pioneering multimodal approach to converge different areas of neuromuscular research, AxoMyoGlia aims at uncovering general pathological mechanisms at the interface of basic neuroscience and applied neurology - that will be highly relevant for therapeutic advance in neuromuscular diseases and related disorders of the central nervous system.

Keywords: peripheral nervous system,neuropathy,schwann cell,axon glia interaction,myelin,demyelinating diseases,charcot marie tooth diseases,neuromuscular unit
Bioengineering of human ossicles as advanced in vivo hematopoietic model (hOssicle)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

hOssicle aims at developing miniaturized human bone organs in mice to be used as advanced model of healthy and malignant human hematopoiesis. In Europe, 80 million people are estimated to suffer from blood disorders. When at all existing, treatments are poorly effective: 92 % of new drugs successful in preclinical testing (animals and in vitro culture systems) fail in clinical trials. This urgently calls for the development of superior models, to refine our understanding of human hematopoiesis and better predict patient´ therapy efficacy. My laboratory has developed unique human mesenchymal lines capable of forming “human ossicles” by recapitulation of endochondral ossification -the developmental process of bone formation. These ossicles form subcutaneously in mice and display a similar structure and function to native mouse bones, but rely on human mesenchymal cells reconstituting a complex bone marrow environment specifically supporting the development of human hematopoiesis. hOssicle will offer the unprecedented custom engineering of human bones to understand the functional organization of its hematopoietic compartment. By genetic reprogramming of mesenchymal lines, I aim at controlling the molecular and cellular composition of the ossicles and study the corresponding impact on hematopoietic development. Finally, I envision the engineering of patient-specific ossicles with mesenchymal and leukemic blood cells from the same individual towards recapitulation of the disease setting. This will be a significant breakthrough, by offering the study of malignancy progression and drug-testing in a personalized in vivo context for cancer remission. By combining principles of bone development & tissue engineering, hOssicle proposes an “organ engineering” approach applied to hematopoiesis. The implications run from the identification of key factors controlling the production of blood cell types to the personalized modelling of leukemia and test of therapies.

Keywords: tissue engineering,regenerative medicine,bone,hematopoeisis,cancer
Chemogenomics and in silico repurposing as an innovative approach for rapid drug discovery in tuberculosis (iCHEMGENODRUGS_TB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Tuberculosis is one of the most worrying Global and Public Health problems in the present day and causes a major economic and social burden, which can significantly drain a society’s resources. In 2015, 10.4 million people fell ill with tuberculosis and 1.8 million died from the disease. In addition, an estimated 480000 people developed multidrug-resistant tuberculosis. The development of new drugs and new therapeutic regimens effective against drug susceptible and drug resistant tuberculosis is one of the greatest challenges in the way of tuberculosis control. Conventional drug discovery strategies are usually costly and time-consuming and, frequently, with low rates of success. This project aims to develop a new paradigm for tuberculosis drug development, using the drug repurposing strategy (to find new uses for already approved drugs) coupled with an in silico chemogenomics method. The focus will be targeting energy metabolism, particularly the oxidative phosphorylation, a novel target pathway in tuberculosis drug discovery. This research project has the potential to greatly benefit tuberculosis drug discovery by finding new drugs for a largely unexplored pathway and by introducing a new approach that can increase the probability of identifying effective drugs and decrease the bottlenecks of the conventional drug discovery approach, saving both time and money. Since tuberculosis has a high social and economic impact, this project aims not only to contribute to scientific and academic knowledge in this field, but also to increase public awareness on tuberculosis drug resistance and the need for new drugs by using several outreach activities. Finally, searching for new effective drugs that can tackle the problem of drug resistance and reduce the costs of drug treatment contributes to the decrease of social impact and economic burden of this disease and is in line with the goals of the World Health Organization “End TB” strategy.

Keywords: tuberculosis,multidrug resistant tuberculosis,comparative chemogenomics,drug repurposing
Affordable organosheets for mass-customised FRP components in multiple sectors (OLU-PREG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain,Germany
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The demand for lightweight materials is growing and has attracted a variety of plastic composite solutions. However obstacles still remain for the mass uptake of composite materials and production technologies, some of them being the low volume production capabilities, the customization of products and related adaptability of processes as well as the low acceptance of the materials due to problems of their recyclability in some sectors. The OLU-Preg technology offers solutions for these problems. The OLU-Preg project aims to accelerate the commercialisation of a patented technology for affordable, continuous fibre reinforced, thermoplastic non-crimp fabric organosheets that will enable highly customised, high-volume FRP applications in multiple sectors. The system has clearly superior formability than similar composite products, and its manufacturing process allows for mass customisation (making organosheets designed for the applications at high volumes and minimum costs of production switching), while additionally being fully recyclable. This unique system has a variety of applications in fabrication of complex, (semi-)structural, light FRP parts. SKL and Berbetores, the two SMEs collaborating for the initial commercialisation of the innovative material, are already exploring potential markets and have identified transport vehicles and agricultural machinery as the two most promising application sectors to target. Two potential early adopters end-users, which are market leaders at European and international level in their sectors, have already expressed their interest in the results of OLU-Preg (Fiat-Chrysler Group and Lely Group). Building on this interest, SKL and Berbetores will work together with key stakeholders that complete the value chain during this Phase 1 to define the most feasible business cases, as well as full market entry strategy and business plan, and so prepare for large-scale production, demonstration and market launch in Phase 2.

Keywords: non crimp fabrics,composites,thermoplastics,automotive,agricultural robots
RANGER: RAdars for loNG distance maritime surveillancE and SaR opeRations (RANGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Finland,Greece,Belgium,France,United Kingdom
Call: Maritime Border Security topic 1: radar systems for the surveillance of coastal and pre-frontier areas and in support of search and rescue operations (H2020-BES-2015, 2015)
Start date: 2016-05-01
End date: 2019-12-31
Duration (months): 44.0
Total project cost (EUR): 7992312.5
EU funding (EUR): 7992312.5
Participants: 11
Project status: CLOSED

EU trade, transport, tourism and economic development are directly dependent on open and safe seas and oceans. EU's maritime borders are widely spread including various topologies from open sea to semi-enclosed cabins with islands and islets. This poses great challenges that affect securing maritime border areas. Failing to protect against a wide array of maritime threats and risks may result in these areas becoming arenas for international conflicts, terrorism or organized crime, where smuggling, irregular immigration and drug trafficking are the most common ones. RANGER aims at re-enforcing EU by combining innovative Radar technologies with novel technological solutions for early warning, in view of delivering a surveillance platform offering detection, recognition, identification and tracking of suspicious vessels, capabilities exceeding current radar systems. It will be a platform, consisting of 2 radar technologies, a novel Over-The-Horizon Radar combined with a Multiple Input Multiple Output one implemented exploiting the latest photonics advancements, and an Early Warning System exploiting deep and adaptable machine learning schemes able to Automatically detect radar Targets. It safeguards seamless fitting and interoperability with CISE (enhanced maritime surveillance and cross border SaR operations), through the development of a CISE translation Gateway, exporting on-demand CISE services directly to end-users, by strengthening the information exchange between national authorities and the European Agency. RANGER leverages the experience of its consortium, a balanced blend of technology providers, domain experts and end-users, delivering a cost efficient, environmental friendly solution, abiding to regulations and legislation for the protection of human lives. Two pilot exercises are foreseen to thoroughly assess RANGER’s ability to deliver on its promises, enhancing its potential to become a flagship platform for the European Maritime Surveillance industry.

Keywords: over the horizon,photonically assisted mimo,radar technologies,fractal arrays,early warning system,cise,maritime border security,deep learning,data fusion,high frequency surface wave radars