Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gravitational interferometry with entangled states in optical fibers (GRAVITES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Austria,United States,Germany,Poland
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-04-01
End date: 2029-03-31
Duration (months): 72.0
Total project cost (EUR): 8870987.0
EU funding (EUR): 8870987.0
Participants: 4
Project status: SIGNED

The four known interactions that occur in nature can be described either by Einstein's general relativity or by quantum field theory. Over the last decades physicists have tried to put these two pillars of modern physics on a common foundation. In doing so, they have been limited by a lack of experiments at the interface of these two frameworks. Both theories have been independently verified with astonishing precision, but all verifications to date have come without drawing on concepts from the other theory. The goal of GRAVITES is to perform experiments at the interface of quantum physics and general relativity. For the first time, we will measure gravitational properties of single and entangled photons in the background of Einstein’s gravity. To this end, GRAVITES aims to combine four complementary disciplines: quantum photonics and precision interferometry guided by expertise in general relativity and quantum field theory. The synergy among the research groups will realize a large-scale fiber interferometer with unprecedented precision. Since the sensitivity of GRAVITES’s apparatus must exceed present large-scale fiber-based quantum interferometers by orders of magnitude, the two experimental teams must combine cutting-edge technologies in their respective fields for advancing single-photon interferometry. These developments are also of direct relevance for many other applications such as quantum metrology and quantum sensing. In parallel, the theory teams will investigate the combined effects of gravitation and field quantization in dielectric waveguides. With this united effort GRAVITES is in the position to explore new physics that determines the gravitational properties of quantum superposition and quantum entanglement. This will allow us to create a unique experimental platform for probing how gravity interacts with the quantum world.

Keywords: quantum photonics,quantum gravity interface
Terahertz Ultra Strong Coupling for mAcromolecules structure aNalYse & control (TUSCany)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1999555.0
EU funding (EUR): 1999555.0
Participants: 1
Project status: SIGNED

MacroMolecules (e.g Proteins, DNA) carry out most of the functions of the living and these functions come from their 3D-structure. For instance, foldopathy like Alzheimer’s and Parkinson’s disease are caused by misfolding of proteins. Modifying this structure non-invasively is consequently a tremendous challenge for both microbiology research and applications. Besides, light-Matter strong coupling (SC) occurs when a material is located at a high density of state of a photonic mode resonant with one of its transitions. Extensively studied in optics and quantum physics, SC recently gave exciting results in chemistry with the demonstration of its ability to change the product ratio of several chemical reactions. Experimental and theoretical results unveil that macromolecules have delocalized vibrations over their whole 3D-structure in the Terahertz (THz) range. Therefore, one can ask if the functions of macromolecules can be modified by implementing strong coupling on the vibration of macromolecules in the THz. In Tuscany, I will develop µ/nano THz photonics devices and experiments to establish reliable methods for macromolecules THz spectroscopy from cryogenic to body temperatures on samples from the single macromolecules to the cell culture. Then, I will demonstrate vibrational SC in the THz on these samples. Finally, I will demonstrate that the function of macromolecules, including catalysis and macromolecules assembly can be modified by selectively coupling individual vibrational modes from the single macromolecules up to in vivo experiments with prion propagation and viral capsid assembly. My overall aim is to understand in detail the vibrational strong coupling in the THz range for macromolecules and make it a useful tool for biochemists and biophysicists. In the longer term, I hope this knowledge will seed the design of new approaches in µbiology leading to medical treatments impeding the proteins aggregation and ultimately the evolution of the foldopathies.

Keywords: terahertz,biophotonics,metasurfaces,macromolecules,strong coupling
Molecular Dynamics Data Bank. The European Repository for Biosimulation Data (MDDB)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,Germany,Switzerland,United Kingdom
Call: Research infrastructure concept development (HORIZON-INFRA-2022-DEV-01, 2022)
Start date: 2023-03-01
End date: 2026-08-31
Duration (months): 42.0
Total project cost (EUR): 2649626.5
EU funding (EUR): 2649626.5
Participants: 7
Project status: SIGNED

After decades of development and a Nobel prize, Molecular Dynamics (MD) has reached maturity. It is no longer an exotic technique used by a small group of theoreticians but rather a method extensively used by a very large community of users. Millions of supercomputer hours are devoted to collecting trajectories, thus producing a deluge of simulation data that the community is unable to handle. A poor tradition of data sharing and the lack of appropriate infrastructures to do so lead to the loss of data after limited analysis that most likely revealed only a small fraction of the information contained. Sparse initiatives to build trajectory repositories have encountered difficulties related to: i) the lack of trust of the community in the reliability of the data deposited; ii) the lack of interoperable standards and simulation ontologies; iii) uncertainties regarding the database technology required; v) difficulties of the users to interact in an open manner with the data; and vi) disconnection of the MD-field with neighboring communities. The MDDB projects intends to design a European-scale repository of MD simulation (and associated analysis tools), which will: i) optimize computational resources; ii) favor the analysis (and meta-analysis) of trajectories for many different perspectives and fields; iii) guarantee a fast and efficient interchange of information between groups; and iv) facilitate the integration of the MD simulation field into neighboring communities. The overall result will be a more efficient use of MD and the integration of the MD field into mainstream biology and chemistry research.

Keywords: molecular dynamics,simulation databases,interoperability,big data,data standards,good practices,fair
Bio-Based Polyelectrolyte Nanoformulations for Foliar Delivery of Multitarget dsRNA: An Approach towards novel BioControl Agents for Crop Protection (SiNanoCrop)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: SIGNED

The impact of plant pests on global crop yields is a significant concern, leading to an annual decrease of more than 30% in crop production. The whitefly alone incurs losses exceeding $300 million each year, primarily due to its role in transmitting harmful plant viruses like the Tomato Yellow Leaf Curl virus (TYLCV), which poses a substantial threat to tomato crops worldwide. The use of conventional pesticides raises environmental alarms, negatively affects beneficial insects, and contributes to pest resistance. Initiatives like the European Green Deal aim to promote sustainable agriculture by reducing chemical pesticide usage by 50% by 2030. Spray-induced genetic silencing (SIGS), harnessing the RNA interference (RNAi) mechanism, has emerged as a promising alternative to conventional pesticides. This non-GMO approach offers a sustainable and pathogen-specific protection method by silencing key genes in target pests through the foliar application of dsRNA molecules. However, certain challenges remain unresolved, including the cost-effective production of dsRNA, the ability to control multiple species simultaneously, and dsRNA stability and transport in crop environments. This project seeks to overcome these challenges by implementing innovative, safe, and cost-effective approaches. Firstly, we will synthesize dsRNA containing regions from both whitefly and TYLCV through microbial fermentation and apply a simple purification method to achieve high-efficiency hybrid dsRNA isolation. Secondly, we will design new biomass-based formulations using nanopolyplexes as carriers to efficiently protect and deliver the dsRNA. Thus, we will develop advanced biocontrol strategies for dual protection against both the insect vector and its host virus in tomato. Through the integration of polymer science, nanotechnology, and biotechnology approaches, our efforts aim to advance dsRNA-based biopesticide technology and facilitate its lab-to-field transition.

Keywords: biopolyelectrolytes,polyamines,nanoformulations,dsrna,biocontrol,crop protection,tomato
Solar for Ice to Thrust (S4I2T)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Bulgaria,Luxembourg,Belgium
Call: EIC Pathfinder Challenge: In-space solar energy harvesting for innovative space applications (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3999590.0
EU funding (EUR): 3999590.0
Participants: 5
Project status: SIGNED

The S4I2T project seeks to develop a cost-effective and environmentally friendly solar electric water propulsion system. It aims to use water as a propellant to enable autonomous spacecraft docking and propellant refilling, promoting economic and environmental sustainability and facilitating in-orbit servicing, robotics, and in-space manufacturing. Furthermore, the project explores in-space water extraction and utilization from celestial bodies, contributing to a self-sustaining circular space economy based on solar energy harvesting. The three technological elements at the project's core are: 1. Solar-Electric Water Electrolysis Propulsion: Water is used as a propellant and decomposed into gaseous oxygen and hydrogen, outperforming traditional chemical propulsion systems. Water's non-toxicity, versatility, and availability make it a cost-effective choice. It also utilizes solar energy for propulsion. 2. Autonomous Proximity/Docking Operations and Propellant Refilling: Water simplifies in-orbit refueling, reducing launch mass and extending satellite lifetimes. This supports in-orbit servicing and assembly, enhancing the impact of solar energy harvesting. 3. In-Space Water Extraction and Utilization: Water extraction from celestial bodies combined with the other technologies creates a self-sustainable space mobility infrastructure, offering long-term, Earth-independent operation. The project aims to achieve several breakthroughs in developing a novel solar-powered propulsion system, addressing technological challenges and bottlenecks. It includes the development and lab demonstration of innovative components for a Solar Electric Water Electrolysis Propulsion System, autonomous proximity/docking algorithms, and end-to-end In-Space Resource Utilization (ISRU) validation. Ultimately, the S4I2T project strives to position Europe as a leader in solar-energy-powered space mobility, fostering a sustainable and self-sustaining space economy.

Keywords: solar electric water electrolysis propulsion,self sustaining space mobility architecture,in space water extraction and utilization,sustainability,autonomous proximity docking,propellant refilling
Linking Academic Research with Entrepreneurial Success (Mind the Gap)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Norway,Bulgaria,Austria,United Kingdom
Call: Expanding Academia-Enterprise Collaborations (HORIZON-EIE-2024-CONNECT-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 532063.39
EU funding (EUR): 499968.75
Participants: 7
Project status: SIGNED

The “Mind the Gap” project unites 7 partners (3 HEIs, 2 business partners & 2 NGOs) from diverse European innovation regions to bridge the gap between academic research and market-ready innovations. The project aims to 1) foster entrepreneurial skills among students & researchers, 2) enhance universities' capacity to support innovators, and 3) stimulate entrepreneurial activity across Europe. Using the 4Cs Framework, the project connects academia, business, and policy actors, creating a dynamic, inclusive innovation ecosystem. Key actions include 1) developing new entrepreneurial courses, 2) tailoring PhD programs, 3) integrating business acceleration, and 4) connecting stakeholders across regions. Addressing six expected call outcomes (i.e., 1) improved knowledge flows, 2) enhanced skills, 3) increased competence, 4) availability of local talents, 5) boosted entrepreneurial activity, and 6) increased youth employability), the project contributes to the New European Innovation Agenda, the European Green Deal, and the EIT HEI Initiative. Leveraging networks from EU initiatives such as CloudEARTHi, SEEDplus, and Inspiring the Minds, the consortium uses its vast expertise in academic-industry partnerships and entrepreneurship to position HEIs as engines of change, driving sustainable growth and strategic autonomy. The consortium’s diverse representation strengthens the Smart Specialization Strategies of partner countries. The project implements measures to promote gender balance, adhere to open science policies, and ensure the long-term sustainability of its activities beyond the project’s end. Through an extensive outreach and dissemination plan, it engages stakeholders—including students, researchers, university staff, policymakers, and the business sector—to position HEIs as leaders in driving Europe’s economic growth, spearheading the global deep tech wave, advancing the green transition, and strengthening Europe’s strategic autonomy and competitiveness globally.

Keywords: entrepreneurial skills new european innovation agenda european green deal eit hei initiative smart specialization strategies
Antibiotic resistance of functional microbes in wastewater treatment systems (ARFMW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

The Urban Wastewater Treatment Directive (UWWTD) adopted by the European Union recognizes biological treatment processes as sustainable and cost-effective solutions for pollutant removal from wastewater, thereby mitigating ecological damage. However, there is a growing awareness that the biological units within wastewater treatment plants (WWTPs) serve as hotspots for antimicrobial resistance (AMR), which presents significant health risks. Preventing the spread of antibiotic resistance genes (ARGs) while maintaining the wastewater treatment efficiency is a great challenge for WWTPs. ARFMW project focuses on functional microbes in WWTPs, which are not only pivotal to pollutant degradation but also potential reservoirs for ARGs. Our objective is to employ a multidisciplinary approach that integrates ecological and engineering principles with cutting-edge multi-omics analyses and molecular techniques, to elucidate the AMR characteristics of functional microbes and their impact on wastewater treatment. Hosted by the Water Technology group, Aarhus University, under the supervision of Prof. Barth F. Smets, I will expand my core research skills in microbial technology and water engineering to operate lab-scale bioreactor for investigating the relationship between the spread of ARGs in functional microbes and the performance of wastewater treatment. During the secondment at University of Helsinki, Finland, under the guidance of Prof. Marko Virta, I will gain complementary skills in advanced molecular techniques (epicPCR) to identify comprehensive host information of specific ARGs. Additionally, this project will augment my transferable skills such as project management, communication and leadership, thereby propelling me to become a mature researcher. ARFMW will also engage with the public to raise awareness about AMR; anticipated results will aid Europe in optimizing its wastewater-based AMR surveillance plan for regional sustainable development regarding clean water.

Keywords: antibiotic resistance genes args,host,functional microbes,wastewater treatment plants wwtps,multi omics,nitrogen removal
Hygge Star Model - a new perspective and application (HYGGESTARMODEL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: France,Poland,Portugal,Latvia,Korea, Republic of
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 647285.71
EU funding (EUR): 556600.0
Participants: 10
Project status: SIGNED

The focal point of this proposal revolves around an interdisciplinary exploration of the HYGGESTRARMODEL—a comprehensive framework designed to assess self-management motivation within organizational contexts. This interdisciplinary inquiry aims to elucidate various facets of the newly conceptualized HYGGESTRARMODEL, spanning theoretical underpinnings, practical applications, and empirical validation. The project addresses a salient HR and managerial problem of how to efficiently motivate Generation Z to engage and perform in the workplace. A pivotal component of this endeavor involves the development of a novel measurement instrument, namely the Universal Hygge Star Questionnaire (UHSQ), tailored to capture the multifaceted dimensions of organizational motivation. Strong empirical verification will be conducted within the Bayesian Averaging of Classical Estimates (BACE) framework, in which we can combine some prior knowledge about model distribution and data. Thus, BACE serves as an example of a Bayesian pooling approach, wherein posterior results are averaged over the entire model space . Furthermore, the proposal entails the formation of a cross-sectoral research team tasked with devising test protocols and rigorously validating the outcomes derived from the HYGGESTRARMODEL. Termed as “Hygge Star Model – a New Perspective and Application” (HYGGESTARMODEL), this project aspires to offer fresh insights and practical implications for enhancing organizational motivation and effectiveness.

Keywords: hygge star model,motivation,bayesian averaging of classical estimates
Geometric constraints and feedback during tissue morphogenesis (GeoMorpho)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 2921360.0
EU funding (EUR): 2921360.0
Participants: 1
Project status: SIGNED

During development, cell movements and shape changes give rise to complex 3D forms. What underlies the fidelity of morphogenesis? To date, much emphasis has been placed on understanding how genes and local mechanics drive cell shape changes and tissue scale morphogenesis. However, the roles of the geometric properties of a tissue and its physical boundaries, their size, dimensionality, curvature and overall shape have recently emerged as important yet overlooked features of morphogenesis. This interdisciplinary project will unravel how geometry and geometric feedbacks constrain lower scale cell mechanics and how they contribute to tissue morphogenesis. We will study the interplay between geometry and active mechanochemical processes in two systems where physical boundaries constrain and guide morphogenesis. In Drosophila embryos, polarized tissue flow and a wave of tissue invagination depend on interactions with the surrounding egg envelope called the vitelline membrane. This envelope imposes tissue curvature, forms a rigid adhesive substrate, and confines the diffusion of molecules within the extra-embryonic fluid. Likewise, formation of the wing during metamorphosis in the pupa is associated with a dramatic expansion of the tissue surface within a rigid pupal sac forcing a complex tissue packing without compromising flatness in adulthood. The mechanics of tissue flow and expansion are unknown. How flows within these constraints give rise to folding needs to be characterized. These two systems share key similarities: their dynamics depend on the flow, expansion and folding of tissue layers, and 3D deformations are driven by internal active stresses and external constraints from rigid boundaries. In both cases we will dissect the mechanochemical active processes driving cell and tissue deformations and address how geometrical constraints impact cell and tissue mechanics. This project will thus reveal how tissue shape affects the processes from which shape emerges.

Keywords: tissue mechanics,tissue geometry,drosophila morphogenesis