Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Terahertz OPtoelectronics in BiLayer Graphene (TOP-BLG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2337500.0
EU funding (EUR): 2337500.0
Participants: 1
Project status: SIGNED

The terahertz (THz) spectrum, which lies on the seam between the optical and electrical spectral ranges, is ubiquitously important for science and technology, from chemical/biological sensing to stellar exploration. Nevertheless, the development of THz applications has been hindered by the sparsity of high-performance and low-cost optoelectronic devices, due to the limited response of common electronic and optical materials in this spectral range. Here, I propose to develop a new THz optoelectronic platform that is based on 2D materials of bilayer graphene structures. Taking this approach, I will realize a variety of new THz optoelectronic devices that can be electrically controlled and are highly compact and low-cost. Outperforming the state -of-the-art, TOP-BLG will constitute a transformative breakthrough in THz optoelectronic devices. Beyond THz technology, I envision that TOP-BLG will have great impact on the integration and dissemination of 2D materials into the microelectronics/optoelectronics technological market.

Keywords: terahertz optoelectronics,2d materials optoelectronics,
Population Trajectories and Cultural Dynamics of late Neanderthals in Far Western Eurasia (FINISTERRA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1899696.25
EU funding (EUR): 1899696.0
Participants: 1
Project status: SIGNED

In recent years, knowledge of the processes involved in the disappearance of the Neanderthals and the successful expansion of our species across Eurasia has substantially increased. Still, the spatiotemporal variability of the presumed mechanisms behind Neanderthals’ demise – climate change, fragile demography, inter-species competition – makes it very challenging to evaluate the replacement at a continental scale. The Iberian Peninsula, due to its cul-de-sac position and the role of its southern regions as one of the last refugia for the Neanderthals, represents an ideal natural setting for testing models of cultural and demographic trajectories leading to the final disappearance of those populations. FINISTERRA seeks to expand this framework by implementing an integrative, interdisciplinary, multi-scale approach to the archaeological and paleoenvironmental records associated with late Neanderthals in southwestern Iberia. Supported by an unprecedented combination of geoarchaeological, chronological, and paleoecological evidence, FINISTERRA will specifically (1) provide a detailed characterization of late Neanderthal adaptive systems, presenting high-resolution data on the timeline of events leading to their final disappearance; (2) investigate the presence of the so-called early warning signals of Neanderthals’ collapse through the use of cutting-edge quantitative analyses of cultural and demographic trajectories; (3) explore alternative hypotheses of a gradual or sudden loss of Neanderthals’ resilience by considering the impacts of climate change and the spread of modern humans into western Eurasia. The results of this project will have crucial implications for our understanding of the factors contributing to the demise of our sister species, which ultimately were key components for our own success and uniqueness.

Keywords: neanderthals,middle paleolithic,eco cultural dynamics,iberia
THE EUROPEAN DIGITAL HUMANISM INITIATIVE (EUDHIT) (EUDHIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Netherlands,Slovakia,Spain,Norway,Italy,Switzerland
Call: Digital Humanism - Putting people at the centre of the digital transformation (CSA) (HORIZON-CL4-2024-HUMAN-03, 2024)
Start date: 2025-05-01
End date: 2027-10-31
Duration (months): 30.0
Total project cost (EUR): 1577125.0
EU funding (EUR): 1499125.0
Participants: 12
Project status: SIGNED

The European Digital Humanism Initiative (EUDHIT) aims to promote the creation of a more resilient, inclusive, and democratic society that fully aligns with the principles of Digital Humanism. It builds on previous work and EU policies including within the Digital Decade programme. EUDHIT will help realizing the EU Declaration on Digital Rights and Principles. EUDHIT assembles DigHum organisations, experts, networks, and other communities that help realize the vision. It supports industry on its path to creating, maintaining, and taking-up successful IT systems realizing the principles of digital humanism with concrete frameworks, standards, and tools. It helps policymakers in supporting conditions fruitful for digital humanism and in developing a prosperous society with the help of digital humanism know-how. It facilitates digital humanism innovation in startups and other businesses, guides IT investments towards digital humanism technologies and makes progress towards these objectives measurable with metrics and indicators. EUDHIT joins ICT experts, scholars from sociology, economy, social innovation, law, ethics, anthropology, business and innovation studies and other disciplines into cross-disciplinary working groups on challenging open issues of digital humanism. EUDHIT delivers frameworks, capabilities, tools, and recommendations to help realise a societally beneficial digital world to overcome today’s situation that leading researchers and intellectuals perceive as problematic, detrimental to European values and to social achievements. Also, EUDHIT facilitates access to experts, know-how, training, and support for industry, intermediaries, and policy makers.

Keywords: digital humanism,computer sciences,information science,computer ethics
Roughness-induced secondary currents in arterial flows with stents (CARE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Stents are tub nets of varied materials and geometries that are installed in narrowed (stenotic) arteries to preserve their restored diameter following surgical procedure (e.g., angioplasty). Stents add a roughness element to the otherwise smooth walls of arteries, thus altering the hemodynamic environment and the flow characteristics. CARE is inspired by recent results in wall-bounded flows, which have shown that roughness patterns of height much smaller than the flow size may generate secondary currents (SCs), large-scale streamwise vortices (comparable to the artery diameter) that alter flow structure, transport mechanisms, wall shear stress distributions and flow drag, among others. Due to their geometrical properties, stents are ideal candidates for the generation of SCs within the flow, with potentially significant effects on biological processes, e.g., restenosis. CARE will aim at advancing our understanding of SC dynamics in arterial flows by assessing their effects on key hemodynamic parameters and analysing energy exchanges. General guidelines for improved stent designs that control and modulate SCs, by preventing or promoting their generation, will be outlined. At present, roughness-induced SCs in stented arteries are largely unexplored, making the proposed research particularly timely. CARE will be based on laboratory experiments covering a range of flow conditions similar to those that can be found in the main body arteries. Different roughness patterns will be studied, including the reproduction of an actual stent. An advanced stereoscopic particle-image velocimetry system, capable of non-intrusive planar velocity measurements, will be used to study the SC patterns and their effects on wall shear stress distribution, as well as their contribution to momentum and energy exchanges.

Keywords: secondary currents,arterial flow,particle image velocimetry,pipe flow,oscillatory flow
COmposite COnformal LIquid H2 Tank (COCOLIH2T)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Ireland,Italy,Netherlands,Poland,France,United Kingdom,United States
Call: Development of specific aviation cryogenic storage system with a gauging, fuel metering, heat management and monitoring system (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 8726769.5
EU funding (EUR): 8726769.5
Participants: 11
Project status: SIGNED

Alternative fuels such as hydrogen (H2) are seen as playing a central role in a zero-emission future for aviation, but the level of penetration for H2 will depend heavily on scientific and technological breakthroughs to overcome the challenges posed by H2 powered aircraft. The safe and efficient storage of H2 on-board future aircraft is the essential enabler of H2 technologies and will be one of the most complex aerospace engineering challenges that the industry has ever faced. Improvements to existing state-of-the-art solutions includes a better utilization of the available space for fuel storage, adequate insulation techniques to minimize heat leak, continued safe operations, and a weight reduction through low-weight materials, such as thermoset or thermoplastic composites, all while addressing those materials’ inherent challenges (permeability, microcracking, thermal fatigue). COCOLIH2T consortium led by Collins Aerospace is proposing a disruptive concept focused on reducing the impact of the tank’s weight and volume within an aircraft, while ensuring system safety. COCOLIH2T will not only develop a safe composite and vacuum insulated LH2 tank for the aviation sector but has the ambition to go beyond by designing and manufacturing a conformal tank through novel fabrication technologies enabling a reduction of more than 60% in production energy consumption, at least 50% in production time leading to significantly lower manufacturing costs. Additionally, the proposed structure of the tank, based on a multi-material thermoplastic composite concept, is intended to facilitate aircraft structural integration to support overall system weight reduction compared with conventional tank configurations. The key challenge that COCOLIH2T will tackle is the generation of a feasible and affordable design of a conformal variable section box-shape tank while minimizing the boil-off leakages wherever possible. COCOLIH2T’s overall system will be demonstrated at TRL4 by 2025.

Keywords: h2,h2 based aircraft,conformal lh2 tank,composite lh2 tank,gauging,fuel metering,heat management,structural health monitoring,overpressure,thermal management,boil off,sloshing,vaporising
Cell Life Tracking Using Intracellular Lasing Barcodes (CelLife)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Our understanding of diseases fundamentally depends on our knowledge of cells, the building blocks of our bodies. Single-cell analysis has evolved over recent decades, from microscopy of individual cells to modern flow cytometry allowing multiparameter analysis of tens of thousands of cells per second. Typically, these methods are limited to a single-pass analysis, offering a snapshot of cell life from which past and future behaviours are inferred. In addition, they often involve separating cells into 1D and 2D cultures, which do not accurately represent in-vivo behaviour and cell-to-cell interactions. However, 3D cultures pose an additional challenge as imaging and tracking of cells become more difficult due to increased light scattering inside the tissue. In this project, I aim to track individual heart cells throughout their life cycle using custom-made microscopic lasers. Initially, cells will ingest multiple microlasers, each serving as a unique spectral barcode for cell identification. The cells will then undergo imaging and deformability assays and a modified flow cytometer analysis to gather comprehensive data about their initial state. Subsequently, cells will be cultured into a 3D organoid, with the position and contractility of each cell tracked by the coherent emission of the microlasers they contain. Finally, the organoid will be dissociated, and the cells will be re-analysed. This approach will yield extensive data on how the environment impacts individual cells, provide a tool to gather new insights into the evolution of cell behaviour and thus enhance our understanding of cellular processes. Further, the fellowship will facilitate my professional development by allowing me to further my understanding of biophotonics. Working with novel techniques in an interdisciplinary group that has pioneered the use of biointegrated microlasers will allow me to establish myself as a leading researcher at the interface of biology, microfabrication, and photonics.

Keywords: wgm microlasers,cardioid,deep tissue imaging,flow cytometry,self interferometry,multiomics
Bioprospecting and production of bioactive molecules from European bryophytes (BRYOMOLECULES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Italy,France,Spain,Sweden,Poland
Call: Land-based bioprospecting and production of bioactive compounds and functional materials for multiple bio-based value chains (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3629672.5
EU funding (EUR): 3629672.5
Participants: 9
Project status: SIGNED

Liverworts, an ancient group of land plants, are a rich and yet still underexploited source of a wide range of biologically active compounds with high potential for the bioeconomy sector as ingredients of cosmetics/cosmeceuticals and pharmaceutics. However, their slow growth rate in nature and the consequent difficulty to obtain large amounts of single compounds have until now severely hindered the in-depth exploration and exploitation of the full spectrum of activities of liverworts secondary metabolites. Recent breakthroughs in the identification of some of the genes involved in the early steps of liverwort-specific compounds suggest that, in addition to the establishment of improved methods for growth in axenic conditions, reconstruction of liverwort metabolic pathways in heterologous systems is a promising way forth towards the practical exploitation of liverwort biochemical diversity and its industrial scale up. The BRYOMOLECULES project will use a combination of cultivation of axenic cultures and production of the active compounds in heterologous systems to define the most suitable production platform(s) for their large-scale production. The project will achieve a very sustainable use of the chemical diversity of wild EU bryophyte species, a largely untapped source of high added-value natural products, without significant impacts on their biodiversity. Besides the identification of relevant lead compounds for cosmetics/cosmeceuticals and pharmaceutics , another major impact of the project will be the production and release according to FAIR principles of a database of metabolites and biosynthetic genes of European bryophyte species that will fuel in the years to come the development of novel bio-based products based on bryophyte-derived lead compounds, according to the concept of EU valorizing biodiversity for EU bioeconomy.

Keywords: bryophytes bioprospecting axenic natural products cosmetics pharmaceutics inflammation metabolomics transcriptomics metabolic engineering biosynthetic pathways biological activity
Rethinking Inclusion and Gender empowerment: A participatory action research (ReIncluGen)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Belgium,Spain,Italy,Austria,Poland,Netherlands
Call: Gender and social, economic and cultural empowerment (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2990481.25
EU funding (EUR): 2990481.25
Participants: 12
Project status: SIGNED

The ReIncluGen project aims to conceptualise gender empowerment building on the innovative theoretical concept of ‘situated intersectionality’ and study, co-evaluate and co-develop good practices of civil society organisations (CSOs) and media outlets that fight structural gender violence and promote gender empowerment and inclusion. Using participatory and co-creative action research with European CSOs and their members will help us to examine the situated meanings of gender empowerment within different societal spheres with explicit attention to migrant women and girls and their diversity and agency. In doing so we will include a wide variety of CSOs working with and for migrant women and girls focusing on themes such as gender equality, (sexual) violence, representation, socio-cultural participation and labour market integration using education, networking, legal counselling and psychological therapy. To consider the socio-political landscape, we will focus on Austria, Belgium, Italy, Poland and Spain, which vary in terms of gender policies and inequalities and may also impact the CSO practises to foster empowerment. The research objectives are threefold. The first is to use a bottom-up and participatory approach to move beyond the written diversity and gender equality policies and unpack the different conceptualisations of gender ‘empowerment’ across spheres and contexts. The second is to conduct an evaluation and impact assessment of empowering and inclusive trajectories applied in distinct CSOs in order to co-design innovative tools to support their gender empowerment and inclusion. We aim to understand their rationale, linkage with prevailing policies, contextual preconditions of their success, and study their applicability across different organisations, countries and cultural contexts. The third is to examine the discourses and actions of media and digital cultures in strengthening gender empowerment and how they are used and implemented by CSOs.
Effective co-delivery of therapeutic peptides and intestinal permeation enhancers using a double Pickering emulsion oral delivery system (OraPickering)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Therapeutic peptides (TPs) are one of the fastest growing classes of therapeutics with clinical applications in severe and/or chronic diseases like cancer therapy, hormonal or immune disorders, and infectious or metabolic diseases. To date, most TPs can only be administered by invasive injection, which greatly influences treatment costs as well as patient compliance and wellbeing, as e.g. diabetic patients rely on regular insulin injections. Oral delivery of TPs poses a convenient alternative to circumvent these problems, but it is highly challenged by I) the harsh gastric environment detrimental to TPs and II) the poor permeability of the intestinal epithelium to TPs. To tackle these problems, I propose a novel oral delivery system for TPs based on a unique gastric stable Pickering double emulsion, which is able to I) protect TPs from degradation in the gastric environment and II) co-deliver hydrophilic TPs and hydrophobic permeation enhancers (PEs) to the absorption site; the intestinal epithelium surface. Simultaneous co-delivery of TPs and PEs is crucial, but not often achieved. As key deliverables, OraPickering will establish Pickering double emulsions for the encapsulation of hydrophilic TPs and hydrophobic PEs, explore their stability under gastric conditions, and confirm their efficacy and safety for intestinal TP delivery in vitro and in vivo. To implement OraPickering I will join forces with Prof. Nielsen from UCPH, combining my background in material and interface sciences with her expertise in TP delivery and intestinal permeation models and mechanisms. I consider this the ideal environment for my further career development, to learn relevant techniques for drug delivery and gain further experiences to emerge as an independent group leader. In summary, OraPickering provides a novel avenue for oral TP delivery, and thereby contributes to a more facile, safe, and cost-effective administration of TPs in the future.

Keywords: drug delivery systems,oral delivery,emulsions,therapeutic peptides,intestinal absorption