Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INJECTABLE HYDROGELS FOR CARTILAGE REPAIR (Hy2Care)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hy2Care BV is a spin-off company of Twente University, in the Netherlands. It is Hy2Care’s ambition to introduce the first cure to Osteoarthritis (OA). The World Health Organization forecasted that, without treatment, OA will be the fourth leading cause of disability by 2020. Today, there is still no adequate solution for more than 120 million patients worldwide. Therefore OA represents a major economic burden on individuals, health care and social care systems. Hy2Care’s Injectable hydrogels are made out of advanced nanomaterials: During the gelation process the hydrogel is covalently bound to the surrounding cartilage and bone (a unique feature); as a consequence, integration of the repair tissue with the native cartilage is strongly improved. This unique tissue integration realized by the Hy2Care Injectable hydrogel discriminates it from all other products available on the market. The Injectable hydrogels are protected by a number of patent applications. The joint and cartilage regeneration market is projected to rise to € 21.8 billion by 2019. Hy2Care’s material platform also has potential of wide-spread application in the biomedical field. Significant market opportunities have been identified in e.g. wound care (estimated market size of > € 10 billion), cell therapy (estimated market size of > € 10 billion), veterinary medicine (estimated market size of > € 1.5 billion). Also in the life sciences research and development market opportunities are identified. The proposal relates to the work programme topic: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs. The overall objective of Hy2Care’s innovation project is to produce Injectable hydrogels for cartilage repair. The objective of the feasibility study is to verify the technical, economical and practical viability of the hydrogel and to ensure successful market uptake throughout Europe/ Northern America.

Keywords: hydrogel,cartilage,osteoarthritis
Dynamics of Multiple, Interacting and Concurrent Markov Chains (DYNAMICMARCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1400789.0
EU funding (EUR): 1400789.0
Participants: 1
Project status: CLOSED

Markov chains are fundamental processes and have been studied in nearly every scientific discipline in the past 100 years. In computer science, reversible Markov chains, also known as random walks, form the basis of many efficient randomised algorithms which have been successfully applied to a variety of complex sampling, learning and optimisation problems. Nowadays an increasing number of algorithms and processes on networks are based on multiple (concurrent and possibly dependent) random walks, including algorithms for packet routing, content search, graph clustering, link prediction and website ranking. This trend will be reinforced by the steady growth of large-scale networks and massive data sets. However, the existing theory of single random walks is not well-suited to cope with the complexity inherent to multiple random walks, and even for independent walks many fundamental questions remain open. The goal of this proposal is to develop a systematic and rigorous study of multiple random walks. First, we will analyse this random process via commonly used metrics such as hitting times, cover times, mixing times as well as new quantities which are unique to multiple random walks. Then we will connect these quantities to structural properties of the underlying graph. Finally, these insights will be applied to the design of new efficient randomised algorithms for large graphs and distributed networks.

Keywords: randomised algorithms,markov chains,distributed computing,random walks
Constructing Intermolecular Potentials by Combining Physics and Machine Learning (ML Potentials)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Luxembourg
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-15
End date: 2020-03-14
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Statistical-learning approaches are emerging as powerful alternatives to direct approaches to solving the electronic Schrödinger equation for determining the energy and other properties of molecules. Despite the recent success of methods like deep neural networks, these methods are limited to relatively small molecules. The issue is that predicting long-range intermolecular interactions with machine learning requires sampling the vast diversity of chemical environments that occur on an extended length scale, leading to a combinatorial explosion in the amount of training data that is required. To solve this problem, the functional form of the long-range interactions is taken from physical models, but the parameters that enter those expressions (atomic charges/multipoles; induced charges/multipoles; van der Waals coefficients) are determined by combining physical insight with machine learning. In this model, machine learning is used only to predict short-range phenomena like the dependence of atomic charges/multipoles on the molecular structure and the dependence of induced atomic charges/multipoles on the local electric field. The resulting machine-learned physically-motivated atomistic intermolecular potentials are valid for molecules of any size, but only require training data from small- and medium-sized molecules. This development will provide molecular energies with the accuracy of quantum methods, at the computational cost of classical molecular mechanics approaches. This not only allows one to compute interaction energies for large molecules (e.g., the binding energy between a drug and a receptor), but allows the computational screening of molecules based on computed interaction energies. In addition to its transformative computational utility, this pioneering strategy—using physical insight to build a model, then using machine learning methods for the parameters in the model—can be extended to many other problems in chemistry, physics, and materials science.

Keywords: quantum chemistry,molecular physics,physical chemistry
Early Modern Women and Alchemy, 1550-1700 (WALCHEMY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

In 2017 UNESCO pointed out that only 30% of the world’s scientific researchers are women. One reason for this low statistic (according to UNESCO) is the lack of visible female role models. Feminist scholars such as Sarah Hutton, Alisha Rankin and Meredith Ray have turned to the era of the European scientific revolution – the sixteenth and seventeenth centuries – to investigate women’s contribution to the history of science. This research is important because it has spotlighted women scientists from the past and demonstrated that scientific enquiry is not simply a male phenomenon. There is, however, one area in the history of science that is noticeably understudied in relation to women writers but in which they were paradoxically most active: alchemy. Lyndy Abraham and Tara Nummedal have shown that alchemical knowledge – the craft of chemical transmutation, both physical and spiritual – was widely disseminated in this period because of the invention and flourishing of printing. I will concentrate on Anglophone female authors because scholars such as Stanton Linden and Robert Schuler have foregrounded a British male alchemical literary tradition, but have overlooked women’s participation in that tradition. I will produce the first in-depth book-length study to explore the influence of alchemy on early modern Anglophone female authors’ works. In so doing, my project seeks to recover a previously unrecognized female-authored alchemical culture that privileged the transformative power of the female mind, word, body and spirit. By adding the hitherto absent dimension of women’s literary thought and practice to our understanding of the alchemical and holistic mind-set of early modern Britain, this study will make a landmark contribution to the histories of science and women’s writing. As such, it will be a key resource for students and scholars interested in women’s engagement with science and the cross-fertilization between scientific discourses and literary language.

Keywords: alchemy,early modern women s writing,early modern studies,hermeticism,history of science,religion and medicine
High throughput multiplexed trace-analyte screening for diagnostics applications (NanoPD_P)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

There is an enormous need for analytical methods that can achieve simultaneous detection of multiple soluble proteins in complex biological fluids. A technology that can achieve this holds the promise of far-reaching impact in multiple healthcare grand challenges ranging from neurodegenerative disease to several major cancers. This project aims to develop a multiplexed label-free detection of soluble proteins and miRNA in biofluids. The proposed method is universal and if successful this pilot work will build the basis for a general approach for the detection of proteins and small molecules such as miRNA and neurotransmitters in complex unmodified samples.

Keywords: sequencing,big data,dna barcoding,molecular and clinical diagnostics,nanopore
Upcycling of PE and PET wastes to generate biodegradable bioplastics for food and drink packaging (upPE-T)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Austria,Germany,Spain,Spain,Italy,Spain,Estonia,Italy,Spain,Italy,Finland,Finland,Serbia,Türkiye,Greece,Croatia
Call: Upcycling Bio Plastics of food and drinks packaging (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 7826685.0
EU funding (EUR): 7826685.0
Participants: 21
Project status: SIGNED

The upPE-T project aims upcycling recalcitrant oil-based plastics by bioconversion into biodegradable bioplastic for food and drink packaging production. Plastic packaging, which make up nearly 60% of the total plastic waste in Europe, is highly problematic from a waste management- and environmental- point of view due to their durability and resistance to degradation. Polyethylene (PE) and Polyethylene terephthalate (PET) are the leading plastic use in food and drink packaging (43% PE and 19% PET). The sustainable management of this plastic waste has become a very challenging problem for global society. In upPE-T we will include sustainable strategies as an alternative for plastic chemical degradation. The consortium will improve PE and PET depolymerization through enzymatic engineering to positively impact food and drink packaging recycling rate and achieving the European Union expected impact. In upPE-T we will turn PE and PET waste streams via enzymatic degradation and microbial assimilation into raw material for the production of biodegradable bioplastics. In addition, we will simplify the downstream bioplastic recovery process from cell biomass using an efficient and green extraction approach in which toxic solvents are not used. Finally, together with customers and food and drink brand owners, bio-based end-packaging will be demonstrated and validated to ensure fast market deployment. Additionally, in order to ensure 100% of PE and PET recyclability, plastic rejections not optimal for microbial bioconversion into bioplastics will be valorized by their use in building applications instead of be sent to incineration or landfilling. upPE-T will be an important part of the actions for compliance with the European Strategy for Plastics in a Circular Economy.

Keywords: biopolymer,bioplastic,bioconversion,enzymatic plastic degradation,upcycling
Biocrete – Bio-inspired bacteria-based stress-responsive concrete. (Biocrete)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 242929.8
EU funding (EUR): 242929.8
Participants: 2
Project status: CLOSED

The proposed project aims to develop biocrete a bio-inspired stress-responsive concrete. Biocrete will be realized through the cross-pollination of the fields of: bacteria-based self-healing concrete; and bio-inspired organic-inorganic materials synthesis. This cross-pollination will see bacteria incorporated in hydrogel systems for the formation of novel bio-inspired bacteria-activated organic-inorganic composite materials, or bio-composite materials for short. In order to develop these bio-composite materials technologies the applicant will receive advanced training in organic-inorganic materials synthesis, with a focus on calcium carbonate precipitation in polymer hydrogels. He will also master state-of-the-art organic-inorganic materials analysis techniques including serial sectioning by cryo-focused ion beam milling (cryo-FIB), and ultimately by cryo-scanning transmission electron microscopy (cryo-STEM). Such techniques will provide insights on the formation of the bio-composite materials, which will be key in ultimately controlling their morphology and mechanical properties. Biocrete will be born through the incorporation of these bio-composite materials technologies into concrete materials. Biocrete will be tested for its crack sealing and mechanical performance. It is envisaged biocrete have a superior crack healing action over conventional concrete materials, resulting in better functional performance and more durable concrete construction. In preparation for independent research after the project the applicant will also be able to build transferable skills including leadership, mentoring, teaching and grant writing and valorization. The knowledge and skill development gained during the project coupled with the development of a new and exciting research field would be a firm step on the way to the applicant heading his own research group working on the development of ‘Bio-inspired building and construction materials’ at a top European university.

Keywords: bio composite,stress responsive,concrete,bacteria,calcium carbonate,hydrogel,functional,self healing,molecular chemistry
Ultra-low Power Digital circuits for Wireless Medical Implants (UPDWMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-15
End date: 2020-09-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Advances in nanotechnology have made it possible to implant ultra-small electronic sensors in the human body. Interfacing with organs and nervous system, these devices will be a key part of future healthcare technologies. One of the most important components in such a device is the electronic integrated circuit (IC) located right at the signal source. This determines the overall power consumption and size of an implant. However, due to the need for sensitive analog circuits and toxicity concerns, very advanced silicon technology nodes (as in consumer electronics) cannot be used in such ICs. Hence, the power & area consumption is of significant concern. The primary aim of the project is to develop custom, novel ultra-low power digital cells for efficient signal processing and communication circuits for miniature wireless medical implants. This goal fits ideally with the ongoing IMPACT project (in the same group) that aims to develop rice-grain size bio-electronic sensor to monitor cancer tumors. This project will be able to use custom digital cells to optimize this tradeoff between data compression and transmission bandwidth in such a device. The researcher will interact with a multidisciplinary team working on the IMPACT project, including IC designers, physicist, biochemist and clinicians. The highly interdisciplinary work will consider the limitations of such an implant in terms of its sensor functionality and physiological acceptance before deriving the electrical specifications. The researcher will bring her extensive experience in designing low-power CMOS arithmetic and memory circuits to this project. This will complement the existing knowhow in bio-sensors and high-performance sensor interfaces already being developed at the host group. She will receive training in multiple aspects of mixed-signal IC design, full-chip characterization and bio-electronic systems. The host organization will also benefit from her teaching and mentoring experiences.

Keywords: wireless sensor node,low power electronics,custom digital cells
Understanding globalization outside 'global cities': European provincial cities in the first globalization, 1880-1914 (EPCFG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

EPCFG explores how populations in three provincial European cities (Leipzig, Germany; Lille, France; Manchester, England) understood and responded to the experience of globalization. The period of focus is 1880-1914, a critical phase in the history of the phenomenon, sometimes known as 'the first globalization'. A confluence of developments in travel, communications, trade, and cultural exchange led contemporaries to observe that the world was 'shrinking', increasingly understanding themselves and their societies to take shape in a global, not national or European, context. EPCFG has the following objectives. 1. To understand how the interlinked phenomena that constituted globalization were understood in provincial places, that are not typically the focus of histories of globalization, thereby refining historical understandings of the phenomena and the paradigm in general. 2. As such EPCFG responds to a prominent criticism of globalization as a historical paradigm, namely that historians have mainly analysed it at the global scale, failing to understand its multiple local meanings. These two objectives, elaborated with further concrete research actions in Part B of this proposal, will be achieved through a program of training with the supervisor and other experts in global urban history at the host institution, and archival work in the three cities. Archival work, and ultimately research outputs from the project, will be organised round three thematic case studies, each of which will be applied to all three cities. The case studies are A. discourses surrounding travel and transport, especially large projects of transport infrastructure; B. the global flow of commodities and the cities' participation in industrial production; C. the gathering and dissemination of news and information about events across the world, both through local newspapers, and means such as the composition and performance of poetry and song.