Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Zero Emission flexible vehicle platforms with modular powertrains serving the long-haul Freight Eco System (ZEFES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Belgium,Türkiye,Germany,Poland,Austria,Spain,France,Czechia,Netherlands,Italy,Luxembourg,Switzerland,United Kingdom,Sweden
Call: Modular multi-powertrain zero-emission systems for HDV (BEV and FCEV) for efficient and economic operation (2ZERO) (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 35400117.91
EU funding (EUR): 23195078.0
Participants: 44
Project status: SIGNED

Long-haul BEVs and FCEVs need to become more affordable and reliable, more energy efficient, with a longer range per single charge, and a reduced charging time to meet the user’s needs. Next to those, there is a real need to take zero-emission long-haul goods transport in Europe to the next level by executing real-world demonstrations of BEVs and FCEVs spread all over Europe; this also requires that technology soon can deliver on promised benefits (easy handling, similar driving hours & charging/fueling, and high speeds, and ability to operate in complex transport supply chains); flexible and abundant charging points for the rising number of vehicles must be implemented fast and to support this, novel charging concepts are needed. In addition, as multiple needs in the logistics chain exist, require novel tools for fleet managers providing them with better information on ZEV in logistic operation, providing a twin of the real use thereby giving valuable information regarding predictive maintenance, eco-driving etc., providing information on better logistics planning, the (available) charging and refuelling along the route, access to roads and traffic information. ZEFES major outcomes: Executing of real-world demonstrations of long-haul BEVs and FCEVs across Europe to take zero-emission long-haul goods transport in Europe to the next level. Pathway for long-haul BEVs and FCEVs to become more affordable and reliable, more energy efficient, with a longer range per single charge and reduced charging times able to meet the user’s needs. Technologies which can deliver promised benefits (easy handling, similar driving hours & charging/fueling, high speeds and ability to operate in complex transport supply chains). Mapping of flexible and abundant charging/fueling points and novel charging concepts. Novel tools for fleet management to support the rising number of long-haul BEVs and FCEVs vehicles in the logistics supply chains.

Keywords: heavy duty,digital twin
Application of a New Kinetic Microbial Theory-Microbial Transition State- on Enriched Nitrifying Activated Sludge Model (MTSonNAS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Türkiye
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: CLOSED

Traditional engineering models known as Activated Sludge Model (ASM) are commonly used for operation, design, and optimization of wastewater treatment plants. ASM predict microbial growth with simulation and calibration of model parameters which are bound to a range of experimental conditions. Recently, Microbial Transition State (MTS) approach was proposed which is a statistical-physics based theory of microbial growth linking thermodynamic balances and growth rates. A growth equation was derived from these first principles, which links a flux (the growth of microbes) to a force, i.e. the Gibbs free potential energy density in medium contained in randomly distributed substrate molecules. MTS has not been fully verified with experimental data on mixed microbial cultures such as sustained in wastewater treatment systems. As the theory is developed for describing standard microbial growth, conditions such as inhibition of growth by any pollutant compound has not been considered/applied in real systems. The aim of the research is to investigate growth kinetics of two different nitrifying bacteria individually (Ammonia and Nitrite oxidizers) with MTS modeling approach and identify nitirification growth kinetics. Inhibition of bacterial growth with different types of inhibitors will also be investigated in order to evaluate and verify application of MTS model for different guilds in mixed microbial cultures under different environmental conditions. The outcomes of the study will contribute to understanding and control of microbial growth processes in engineered and natural treatment systems. Identification of inhibition kinetics will be used for mitigation of pollution generated from industrial processes as well as theoretical development of MTS theory to be applied in more complex biological process applications. The project is an intersection of environmental engineering, molecular biology, and modeling disciplines which will contribute Green Deal Strategy of EU.

Keywords: microbial growth,kinetics,energy based models,microbial transition state theory,activated sludge model
Spatial Perception and Embodied Autonomy Research (SPEAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Norway,Netherlands,Sweden,Switzerland,Belgium,Germany,Greece
Call: Pushing the limit of physical intelligence and performance (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 6746086.25
EU funding (EUR): 6746086.25
Participants: 10
Project status: SIGNED

The popular unmanned aerial robot designs are inspired by manned aerial vehicles from the early 20th century. Since the 2000s, quadrotor drones have dominated the small aerial robots domain due to their structural simplicity and agility. Is further development bound to incremental improvements in their design alongside progress in the autonomy stack? We argue that future research cannot focus on incremental or separate steps in drone design and autonomy alone. Despite the outstanding progress in various domains –from control to perception and beyond - conventional multirotor systems are subject to multiple limitations that constrain their utilization envelope. Furthermore, today's designers often need to tailor their robots to a specific task in a particular application domain, which however is particularly time-consuming. Unlike the current practice, we propose a novel approach to change the paradigm in the design process. We depart from the compartmentalized approach of human-engineered designs and investigate the holistic co-synthesis of task-specific flying robot embodiment and autonomy through a synergistic combination of evolutionary algorithms and deep learning for navigation. We aim to show the benefits of breeding unconventional "bodies" and "brains”. Bodies rely on an evolutionary combination of rotary wing components, and soft and rigid elements, whereas brains exploit the latest progress in deep neural networks. This fundamental change in the design procedure offers a unique pathway towards more capable, more resilient, intrinsically safe flying robots. Upon its success, SPEAR will drive the robotics community forward and towards automatically designed and task-optimized flying machines with superior performance.

Keywords: aerial robots,embodiment,navigation policy,evolutionary algorithms
TwinDEEPS – Twinning deep-ocean exploration and observation capacity for sustainable development (TwinDEEPS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Portugal,Norway,Netherlands,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 1498972.5
EU funding (EUR): 1498972.5
Participants: 4
Project status: SIGNED

The deep ocean, that comprises 98% of Portugal’s Exclusive Economic Zone, is a vast area with great relevance for the country’s National Ocean Strategy 2030 which aims to balance economic and social development with sustainability of its marine resources. The TwinDEEPS project aims to raise the research profile of the Interdisciplinary Centre of Marine and Environmental Research (CIIMAR) in the Widening country of Portugal, to become a leading institute in the field of deep-ocean exploration and observation, by linking it with top-class leading European partners: the Institute of Marine Research (IMR, Norway), the Royal Netherlands Institute for Sea Research (NIOZ, The Netherlands), and the Alfred Wegener Institute (AWI, Germany). TwinDEEPS is anchored on a highly multidisciplinary and technologically capable consortium with complementary expertise in exploration and mapping of deep-sea ecosystems (IMR), long-term observation and monitoring (NIOZ), big ocean data management (AWI), marine omics and science-policy interactions for conservation and governance (CIIMAR). The transfer of knowledge and the exchange of best practices between partners, through tailored training for excellence and upskilling for leadership activities, will result in a new generation of highly qualified deep-sea researchers and research managers, enhancing the reputation, research profile, and attractiveness of the Widening institution, and promoting talent mobility. Using strategic and creative networking activities, combining participatory and cross-leveraging approaches, TwinDEEPS will build a community of practitioners to co-design a roadmap for a national multidisciplinary deep-ocean observing strategy. A joint R&I project, focussed on a full-scale characterization of an emblematic deep-sea ecosystem (Gorringe Bank), will use state-of-the-art at-sea, in-lab, and in-silico technology and serve as a demonstrator of the strengthened scientific and management capacity enabled by this partnership.

Keywords: marine sciences,deep sea ecosystems,exploration and observation,biodiversity and ecosystem function,omics,data management,conservation,networking and training
Unique non-invasive pace-mapping system to identify subjects at risk of arrhythmic sudden death (HELP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2488400.0
EU funding (EUR): 2488400.0
Participants: 1
Project status: SIGNED

Sudden Sudden cardiac death (SCD) is a common cause of adult mortality in western countries, accounting in Europe for about 350 000 cases annually. Most SCDs are caused by ventricular arrhythmias generated from an arrhythmogenic ‘substrate’ present within the heart. Paradoxically, despite the existence of efficient preventive therapies, the sole available predictor of SCD is a measure of cardiac contractility, an indirect metric, which applies only to a subset of patients. At present, most patients at risk cannot be identified pre-emptively to prevent sudden death. My aim is to develop a novel non-invasive body-surface mapping and pacing system, which will allow detection of cardiac signals related directly to the substrate responsible for lethal arrhythmias, for efficient SCD prediction. The unique approach proposed to achieve this objective will consist in: (1) combining electrocardiographic mapping and ultrasonic pacing technologies during cardiac signal acquisition from a high-density array of body surface electrodes; (2) characterizing micro-scale temporal, spectral and spatial features of substrate signals, at baseline and during pacing to unmask hidden signals; (3) establishing critical signal features specific of arrhythmogenic substrates using multi-parametric signal analysis on the body surface, based on unique electrophysiological data from explanted human hearts and from SCD survivors; (4) developing risk prediction scores from well-phenotyped groups of patients monitored by implanted devices. This project will constitute a new paradigm in clinical cardiac investigations and allow a major breakthrough in the prevention of premature arrhythmic deaths in the world. The capability of detecting and influencing cardiac electrical signals will also dramatically impact the management of populations suffering from other cardiac pathologies, enabling earlier diagnosis of heart disease, and better guidance to drug, interventional or preventive therapies.

Keywords: sudden cardiac death risk prediction cardiac arrhythmias non invasive electrocardiography non invasive cardiac pacing
Targeting Mfrn2 to Inhibit Metastatic Cancers (MetaIron)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Metastasis formation is the leading cause of death in cancer patients. Thus, there is an unmet need for drugs that can prevent and/or treat systemic metastases. We have discovered that breast cancer cells rely on a solute carrier (SLC) transporter for metastasis formation in lung and liver. Interestingly, systemic inhibition of this SLC transporter using a therapeutic modality has likely a favorable toxicity profile because knockout mice are viable and have very few and minor phenotypic changes. Therefore, we hypothesize that targeting the SLC transporter can be exploited to inhibit metastatic growth. To valorize this SLC transporter as a drug target, we will 1. Perform a detailed mechanistic analysis of its function in samples from breast cancer patients; 2. Define the efficacy profile of the inhibition of this SLC transporter against systemic metastasis in mouse models; 3. Translate the SLC transporter inhibition beyond breast cancer; 4. Determine the efficacy and safety of targeting metastatic patient-derivedxenograft (PDX) with anti-sense oligonucleotides (ASOs) against this SLC transporter and 5. Delineate a strategy to define small molecule inhibitors against the SLC transporter. To do so, we will apply multiplex immunohistochemistry in samples from breast cancer patients and perform state-of-the-art metastasis assays in allograft, xenograft and PDX mouse models. Thus, we will deliver a comprehensive evaluation of the SLC transporter as drug target for treating metastases.
Novel, orally available immune modulator MP1032 with anti-SARS-CoV-2 and anti-cytokine activity (iMPact)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Research and Innovation actions
Countries involved: Switzerland,Germany,Netherlands,Austria
Call: Vaccines & therapeutic clinical trials to boost COVID-19 prevention and treatment (HORIZON-HLTH-2021-CORONA-01, 2021)
Start date: 2021-08-01
End date: 2023-04-30
Duration (months): 21.0
Total project cost (EUR): 7988724.5
EU funding (EUR): 7988724.25
Participants: 6
Project status: CLOSED

The current global COVID-19 pandemic has caused severe health and socio-economic challenges. Despite significant improvements in the treatment of critical COVID-19 patients and advances in vaccine development, there is still an urgent need for safe and effective early-intervention treatments. To reduce disease burden, hospitalization time, and mortality, it is of critical importance to halt disease progression in early (mild-to-moderate) stages. Our new drug, MP1032, has a dual mode of action, targeting two important mechanisms (immune system overactivation and viral replication) in the early development of COVID-19. Its unique mechanism of self-regulation prevents immune-suppression, which is critical for early intervention. In combination with the oral availability, favourable safety profile, rapid and affordable production scale-up, and potential to work against viral variants, MP1032 is the ideal candidate for early treatment of COVID-19, which can also be used safely in high-risk patients. Therefore, the iMPact project aims to clinically validate MP1032 in a Phase II trial for its ability to stop COVID-19 disease progression. The outcome of the project shall serve as a basis for follow-up rapid Phase IIb/III development and market registration. Four international SME’s will work together in the iMPact project to achieve the objectives: 1) To demonstrate the efficacy of MP-1032 in hospitalized COVID-19 patients, 2) To demonstrate the effect of MP1032 on current SARS-CoV-2 variants, 3) To develop a GMP-compliant production scale-up process for MP1032, 4) To ensure that the clinical development plan is in line with regulatory requirements and 5) To collaborate with existing EU research networks. We have 29 clinical sites on board, and the required expertise for upscaling GMP manufacturing and regulatory preparation is available, ensuring that, by October 2022, MP1032 will be ready to progress to Phase IIb/III trials.

Keywords: ros,anti inflammatory,viral replication,self regulatory,variant agnostic,early treatment,gmp production scale up,pip
O.S.C.A.R.S. - Open Science Clusters’ Action for Research and Society (OSCARS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: France,Switzerland,Germany,Spain,Italy,Netherlands,Norway,Austria,Slovenia,Finland,Czechia,Belgium,Poland
Call: Build on the science cluster approach to ensure the uptake of EOSC by research infrastructures and research communities (HORIZON-INFRA-2023-EOSC-01, 2023)
Start date: 2024-01-01
End date: 2028-06-30
Duration (months): 54.0
Total project cost (EUR): 24998586.25
EU funding (EUR): 24998586.25
Participants: 24
Project status: SIGNED

O.S.C.A.R.S. - Open Science Clusters’ Action for Research and Society The OSCARS project brings together ESFRI and other world-class research infrastructures organised in five "Science Clusters", ENVRI-FAIR (environmental science), EOSC-Life (life science), ESCAPE (astronomy and particle physics), PaNOSC (neutron and light source science) and SSHOC (social science and humanities) that have cooperated over the last four years to rise the efficiency and productivity of researchers by providing open data services and infrastructures for discovering, accessing, and reusing data. The proposed OSCARS project aims at combining individual cluster-based key activities and new shared strategic pathways towards two major objectives: (A) consolidating achievements from the five H2020 INFRA-EOSC-2018-01-04 projects into lasting interdisciplinary services and working practices; (B) leading and fostering the involvement of a broad range of research communities in EOSC via the development of new open science projects, that together will drive the uptake of FAIR-data-intensive research throughout the European Research Area (ERA).

Keywords: esfri research infrastructures,eosc,science clusters,fair data,open science
What is a well written text? Holistic and analytic assessment of text quality in L1 and L2 Italian (WeWriTe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 368071.68
EU funding (EUR): 368071.68
Participants: 3
Project status: SIGNED

The quality of a written text is often described in figurative terms, such as clearness and smoothness. The explicit description of what makes a text clear and smoothly flowing is a challenging task, probably because the readers’ perception of a text is influenced by multiple variables, related to the way information is structured, and how the writer employs the lexical and morphosyntactic resources of a language. The difficulty in translating the readers’ perceptions of a text in measurable descriptors leads to challenges in literacy education. For instance, how can educators explain what makes a text clear and smoothly flowing? What are the crucial aspect to focus on when giving feedback or conducting formative assessment? Answering these questions is of fundamental importance, given that writing literacy may have a considerable impact on employability, social participation and lifelong learning. This project aims to explore the relationship between the holistic evaluation of texts, carried out by expert evaluators, and their linguistic characteristics, to understand to what extent it is possible to identify objective and measurable properties that distinguish texts perceived as well written, compared to those with less positive ratings. For this purpose, we will establish a corpus of argumentative and narrative texts, written by university students, who are L1, L2 (or L3) speakers of Italian, a language that has received little attention so far in international research on writing. The methods of analysis involve the use of linguistic indices identified by previous research, which focus on the lexical and morphosyntactic complexity of the texts, and their integration with new indices, based on the Basel model of text analysis. This model contributes to a deeper understanding of the architecture of a text, by analysing how information is structured and hierarchized, and how textual units are connected on different semantic-pragmatic levels.

Keywords: analysis of texts in italian,basel model of text analysis,the architecture of a written text,holistic and analytic assessment of written texts