Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DESIGN PRINCIPLES IN THE STEREOSELECTIVE CATALYSIS WITH GOLD COMPLEXES. (CHIRGOLD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-15
End date: 2010-04-14
Duration (months): 23.0
Total project cost (EUR): 159261.86
EU funding (EUR): 159261.86
Participants: 1
Project status: CLOSED

A novel approach in catalyst development will combine established principles of ligand design in asymmetric catalysis, the use of chiral counterions, as well as the metallophilic aggregation of Au(I) centres in oligonuclear gold complexes. This is proposed to lead to new efficient stereoselective catalysts based in gold(I) which will be employed in C-C and C-X coupling reactions as well as enantioselective hydrogenations.

Keywords: organometallic chemistry,homogeneous catalysis,macromolecular chemistry,asymmetric catalysis,gold
Enhancing natural wastewater treatment systems: the role of particles in sunlight-mediated virus inactivation (PARVIRDIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-07-01
End date: 2010-06-30
Duration (months): 24.0
Total project cost (EUR): 188793.57
EU funding (EUR): 188793.57
Participants: 1
Project status: CLOSED

The processes by which viruses are inactivated in sunlight-exposed surface waters remains largely unknown. This lack of information severely limits our ability to predict the efficiency of and rationally design natural treatment systems that utilize sunlight-mediated inactivation (e.g., constructed wetlands). Viruses commonly associate with particles in surface waters, including photoreactive particles that can 1) adsorb viruses and 2) produce reactive oxygen species (ROS) when exposed to sunlight. Virus adsorption onto the surface of photoreactive particles exposes them to elevated ROS concentration and may increase inactivation compared to free viruses. The goal of this research is to characterize the adsorption and inactivation of particle-associated viruses in the dark and exposed to sunlight, with the aim of predicting the fate of viral pathogens within natural systems and using this information to improve their efficiency. We will quantify how different viral characteristics (e.g., isoelectric points, capsid size and composition, genome type) influence adsorption and inactivation, and which modes of inactivation are dominant (e.g., ROS damage to viral host binding sites, destruction of viral capsids by ROS or adsorption, and modification or destruction of genomic nucleic acids by ROS or nucleases). To aid in this study, a novel qPCR-based method for determining virus viability will be developed, a tool that will be of use for a variety of fields including environmental microbiology, public health and medicine. The detailed information gathered in this study will then guide the development of methods to improve the viral removal efficiency of a highly controllable constructed wetland. Different wetland configurations will be tested to promote virus adsorption onto iron-oxide coated sand and to maximize viral exposure to ROS. In so doing, this project will increase the efficacy of low-cost, effective systems for water and wastewater treatment.

Keywords: sustainable wastewater treatment,water quality monitoring,health and environment (environmental protection),virus detection,virus inactivation,sunlight,reactive oxygen species
Reaction Sequencing: A concise asymmetric approach to the antibacterial pleuromutilin (SEQUENCING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-03
End date: 2008-11-02
Duration (months): 8.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

Resistance to antibiotics is a major concern worldwide and has led to an urgent need to identify antibacterial agents with modes of action distinct from the established classes. The antibacterial natural product pleuromutilin is such a candidate and has been the focus of biological and medicinal studies in recent years. Unfortunately, pleuromutilin has poor pharmacokinetic properties and the compound is readily metabolised by enzymes. Although the natural product itself is not a very good drug, analogues of pleuromutilin look promising. This project will provide access to analogues of the natural product with drug–like properties that cannot currently be prepared, thus paving the way for new therapeutics based on the pleuromutilin scaffold that will improve the quality of life of people in the European Community We will develop new stereoselective processes in which the sequencing of a number of individual chemical reactions allows access to a complex, cyclic system in one synthetic step, using one reagent. We will assemble the skeleton of the antibacterial, pleuromutilin using the lanthanide reagent SmI2 to orchestrate the reaction sequencing so that we get a high yield while achieving good control over the stereochemistry of the product. Our proposal is that different parts of a molecule will react one after the other in an ordered sense, like toppling dominos, until a pleuromutilin–like product is reached. The results of our work will be of interest to synthetic chemists working in academic and industrial laboratories in Europe and throughout the world. The specific objectives of the multidisciplinary project are: - to investigate the individual reaction steps of the proposed sequence using model compounds. - to develop reaction sequencing in a concise synthesis of the tricyclic core of pleuromutilin. - to develop the first asymmetric route to pleuromutilin. - to prepare analogues of pleuromutilin and to carry out their preliminary biological evaluation.

Keywords: organic chemistry,radicals,cyclizations,natural product synthesis,pharmaceutical chemistry,antibacterials
Developement of robust and quantitative biosensors based on near-infrared two-dyed silicate nanoparticles (NIRNANOBIOSENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-01
End date: 2010-04-30
Duration (months): 26.0
Total project cost (EUR): 158694.85
EU funding (EUR): 158694.85
Participants: 1
Project status: CLOSED

The aim of this project is to develop quantitative biological sensors based on fluorescent spherical silicate nanoparticles (amorphous silica, zeolite beta) in controlled sizes in the range of 50 to 200 nanometers in diameter. The quantification of the analyte is based on a ratiometric detection of fluorescence from two dyes. The dyes are chosen such that the fluorescence of one dye is a function of an analyte (ion, biomolecule) concentration (sensing dye) whereas the fluorescence of the other dye is independent of variations in the medium (reference dye). Both dyes have the near-infrared light absorption property which lead to significant improvements for the detection in biological samples. The first step consists in confining a dye in the inorganic network yielding highly brilliant and photostable objects. Thus this fluorescent hybrid core can be used as the reference dye. Afterwards the ability of such material to undergo further chemical modification through the surface silanol functions and the use of coupling agents allows the immobilization of the sensing dye (commercially available or developed in the host structure). This is considered through various strategies e.g. direct immobilization or embedded polymeric shell.

Keywords: materials chemistry,organic chemistry,surface chemistry,colloids,biosensors
Strategy of piliated meningococci to cross multicellular defense barriers (T4P_CROSSING_BARRIER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 232597.61
EU funding (EUR): 232597.61
Participants: 1
Project status: CLOSED

The main goal of this proposal is to determine how the deadly bacterial pathogen, Neisseria meningitidis (NM), crosses the blood-tissue barriers and invades the brain and other vital organs. The main hypothesis behind this project is that NM, by interacting with the vascular endothelial cells with its pili, induces a signal that opens cell-to-cell junctions and allows the bacteria to penetrate the natural barriers using the paracellular route rather than the transcellular one as currently accepted. The methodology to be applied involves multidisciplinary approach with advanced imaging techniques, mass spectroscopy, basic cell biology and molecular genetics, and is aimed to take advantage of complementary expertise of involved research partners to solve this burning clinical issue. Understanding the mechanism by which a bacterial pathogen invades the brain and other organs will have consequences beyond the field of medical bacteriology, and will allow insights into regulation of cell polarity. Information gained from this study will be aid in the design of vehicles that mimick signals generated by N.meningitidis, and thus contribute to the design of new systems for the delivery of drugs beyond the blood brain barrier.

Keywords: neisseria meningitidis,type iv pili,blood-tissue barrier,paracellular route,three-dimensional meningococcal clusters,cell motility and polarity,tight junctions,trafficking,caveolae,actomyosin
Interacting two-component quantum gases in micro-magnetic traps (2MODEACHIP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-08-01
End date: 2010-07-31
Duration (months): 24.0
Total project cost (EUR): 160568.25
EU funding (EUR): 160568.25
Participants: 1
Project status: CLOSED

The proposed research aims to explore the many-body physics of the one-dimensional (1D) interacting spinor Bose gas and to study controlled state-dependent interactions between arrays of atoms on atom chips. Two unique atom chips are available for the project; an electromagnetic atom chip specifically designed for producing 1D Bose-Einstein condensates (BECs) and a novel magnetic lattice atom chip based on a patterned FePt film. We will produce 87Rb BECs in two hyperfine spin states on the atom chips, providing experimental access to new and exotic quantum systems. The addition of radio frequency (rf) dressed-state potentials allows for state-dependent control of the atoms, dramatically increasing the versatility of our experiments. We will investigate the thermodynamics of the interacting 1D spinor Bose gas, which allows for a direct comparison with exactly solvable models in many-body physics. Atoms prepared in superpositions of hyperfine states on the chips will, for the first time, allow for studies of coherent spin excitations and transport in the 1D regime and of internal state coherence near the surface of a magnetic film atom chip. Finally, a state-dependent atomic shift register, the combination of the magnetic lattice and a time-dependent rf field can be used to introduce controlled collisional interactions between atoms in neighbouring sites; the basis for generating entanglement of neutral atoms on atom chips. This fellowship will constitute the next step in my career as a researcher and will provide a firm basis for independent research in the future. This work will contribute to strengthen European research and international collaborations in particular with the Australian region.

Keywords: physical sciences,atomic physics,bose-einstein condensation,atom chips,one-dimensional quantum gases,magnetic lattices
Identification of key chemokine-chemokine receptor interactions that control the memory Th2 cells in allergic asthma (TH2MEMORY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-06-16
End date: 2010-06-15
Duration (months): 24.0
Total project cost (EUR): 227092.62
EU funding (EUR): 227092.62
Participants: 1
Project status: CLOSED

Allergic asthma is a disease of airway inflammation caused by an allergic reaction to an antigen. Pathogenic CD4+ T helper type 2 (Th2) cells in lungs are involved in the initiation and perpetuation of the allergic response in airways of asthmatics and animals. Mouse models generated by systemic immunization and respiratory tract exposure with inhaled antigen or by adoptive transfer of effector Th2 cells into naive mice develop eosinophilic inflammation, mucus hypersecretion, and airway hyperreactivity. To mimic disease in asthmatics, we developed a relapsing-remitting mouse model, in we investigate mice during remission and secondary antigen lung challenge induced relapses. Recovered mice are characterized by the presence of Th2 memory lymphocytes in lungs for their lifetime. Exposure of recuperated mice to inhaled allergen reactivates these lung CD4+ Th2 memory cells, consequently initiating disease relapse. The factors governing the survival and retention of CD4+ Th2 cells in the lungs are unknown. One possibility is that memory CD4+ Th2 cells are retained in the lungs by chemokine- chemokine receptor (CKR) interactions. The objective of this project is to identify key chemokine-CKR interactions that control the migration of Th2 cells. We propose specifically, 1) to determine CKR expression on resting CD4+ T cells in the lungs during remission and correlate phenotype with effector function; 2) to identify the critical CKR expression on Th2 cells allowing them to immigrate from the lung during antigen exposure; and 3) to define antigen-specific Th2 cells using a novel transgenic adoptive transfer system. Discovering a reliable phenotype that distinguishes memory Th2 cells in the lungs would allow for their isolation and characterization and potentially lead to new approaches to prevent disease relapses and progression of allergic asthma.

Keywords: chemokine,chemokine receptor interactions,memory th2,allergic asthma,mice,immunological memory
Defining and Assessing Rurality/Urbanity and Delineating Rural/Urban Areas in Europe (DARDRA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-01
End date: 2010-12-31
Duration (months): 24.0
Total project cost (EUR): 178307.05
EU funding (EUR): 178307.05
Participants: 1
Project status: CLOSED

The conceptual rural/urban area definitions can be divided into two main categories based on whether they favour spatial (population and settlement density characteristics based on population and/or land use/cover data, and relative-location characteristics) or non-spatial properties (demographical, social, cultural, economic and ecological characteristics). Policy related definitions evolve together with their main objectives. With the recent increasing integration of environmental concerns into most of the (EU) policies and the growing availability of spatial data on the environment (associated with information technology advancement), a number of initiatives have been launched to develop environmental indicators for policy impact evaluation, with many of them being based on spatial data (e.g. Corine Land Cover), including the ones for alternative rural/urban area definition development. The main objective of the project is to develop methodology for quantification of settlement system morphometric attributes indicating rurality/urbanity based on land cover spatial structure data and population spatial distribution data. While it will be applied to most of the European territory, some smaller model areas will be selected within Europe for specific applications (e.g. finer/coarser scale effect testing). Rurality/urbanity assessment will take into account not only the composition, but also the configuration component of land cover structure. This will be accomplished through application of some known as well as new landscape metrics / spatial pattern metrics. Additional purpose suited metrics will be developed (using e.g. Nearest Neighbour Index, Ripley's K, Moran Correlogram) capable of measuring the intensity of dispersion at different scales. The impact of each of the land cover structure component will be assessed with expert method. In the process, the issue of scale will be of major interest (e.g. upscaling/downscaling, convolution/deconvolution).

Keywords: geographical information science,human geography,rural,urban and regional development policies,spatial planning,environmental policies,settlement system,land use/cover,landscape metrics,scale
The Drosophila homolog of the human disease genes SPG6 and ichthyin - its role in BMP and TGF-beta signaling (SPICT BMP TRAFFIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-08-15
End date: 2010-08-14
Duration (months): 24.0
Total project cost (EUR): 168823.92
EU funding (EUR): 168823.92
Participants: 1
Project status: CLOSED

Spichthyin (Spict) is the Drosophila homolog of the human disease genes SPG6 (mutated in some hereditary spastic paraplegias) and ichthyin (mutated in some ichthyoses). The host lab has recently assigned a cellular role to this protein family, by showing that Spict is an endosomal membrane protein that antagonises the BMP signaling pathway in neurons and S2 cells, causing internalisation of receptors from the cell surface to the endosome. The main goal of this project is to understand how Spict affects BMP signaling. Binding partners of Spict will be identified, and validated by biochemical and microscopic methods. Effects of manipulating binding partners, on localisation and trafficking of Spict and BMP receptors, will be tested. Trafficking pathways of Spict, BMP receptors and if possible of any novel binding partners, relative to other membrane-bound markers relevant to BMP signaling,, will be investigated, using both fixed and live preparations. Using these approaches we aim for a better understanding of the intracellular membrane trafficking pathways of BMP receptors. This will be important both for our basic biological knowledge of a pathway of wide important in development and neuronal function, and for understanding mechanisms of pathology that may be relevant to a range of motor neuron and axonal degenerative diseases.

Keywords: cell biology
Becoming Intercultural - the Diversification of the Political Subject in Multicultural Societies A Theoretical and Practical Approach (BECOMING IC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-08-01
End date: 2010-07-31
Duration (months): 24.0
Total project cost (EUR): 171843.13
EU funding (EUR): 171843.13
Participants: 1
Project status: CLOSED

It is agreed that multiculturalism (MC) has become one of the dominant discourses in Western political theory and practice concerning the needs and demands of weakened minorities, giving increasing attention to issues of identity and recognition of cultural difference. Despite nearly thirty years of political experiment and research, pressing questions concerning weakened minorities' status within Western democracies are still disputed. Principally, this research project claims that issues of intercultural (IC) interaction between different and conflicting communities have scantily been addressed by the MC paradigm. Based on empirical phenomena and philosophical perspectives, the main research object goes beyond MC assumptions and politics focusing on IC practices and their effects on the MC state of affairs. Then, the project will develop a theoretical framework for interpretation of (i) the properties of day to day social, IC practices between individuals and groups across different communities in European societies, and of (ii) the diversification of the construction of subjectivity and identity as a result of the incorporation into practices and modes of thought together with cultural others in various micro-social spheres. The research will be conducted using the philosophical tool-kit of post-structuralist critical thought in cultural studies and politics principally those of the French philosophers G. Deleuze and M. Foucault. At the practical level, the project engage with the insufficiency of present MC politics to cope with the heterogeneous state of affairs in European societies, making sense of IC practices and their effects on the changing operations of power across the socia field in specific spaces of action, both for inter-group relations and the self. Thus, the project places philosophical research at the service of political action in the public space, especially with a significant contribution in the confrontation with racism and xenophobia.

Keywords: interculturalism,multiculturalism,subject formation,post-structuralism,inter-group relations
Formation and evolution of planetary systems (PROTOPLANETARY DISKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-01
End date: 2010-03-31
Duration (months): 24.0
Total project cost (EUR): 168256.91
EU funding (EUR): 168256.91
Participants: 1
Project status: CLOSED

The goal of this research project is to obtain a global and precise view of protoplanetary disks. To define a consistent line towards this long term objective, the proposal will rely on 1) an extension of multi-wavelengths modelling of disks, on one by hand, by generalizing this kind of studies to an increasing number of disks, on the other hand, by including complementary observations, in particular coming from very large equipments. This step will go through a continuation of the efforts on numerical modelling to 2) take into account radiative transfer in the gas phase of disks (kinematics and abundances). The long term research programme will take part in a willing to develop 3) an approach linking in complementarity observations and modeling of physical processes within disks so as to bring quantitative observational constraints to the models of disk evolution and planet formation.

Keywords: astrophysics,star formation,radiative transfer,computational physics,3 d modelling,modelling tools