Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Responsibility of International Organisations for Human Rights Violations (RESINTORG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2015-03-09
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

States increasingly transfer or delegate powers on international organisations, which, in turn, exercise ever more public authority and act in some instances even as a substitute for a State. However, the continuous transfer of powers from States to international organisations has not been followed by the creation of a corresponding concept of responsibility for international organisations. At present, their exercise of public authority lacks some of the most essential control mechanisms, in particular in the field of human rights. Human rights violations may occur, inter alia, during their military or peace-keeping operations, or under their administrative authority over certain territories. The research therefore aims to develop a system of responsibility of international organisations for human rights violations, which would enable a review of their actions and sanction any misconduct, similar to the system of checks and balances established in democratic states. In order to develop such a system, the research will a) identify which human rights norms are binding on international organisations and determine their exact content and scope of application; b) refine the rules on attribution of responsibility to an international organisation c) identify the authority which could establish responsibility of international organisations; and d) clarify the legal consequences of human rights violations and examine possible remedies. The research thus represents the first comprehensive study of responsibility of international organisations in the field of human rights law. Such regime of responsibility will contribute to the protection of human rights from abuses by international organisations as some of the most important power-holders and will raise the legitimacy of international organisations. It will also raise the legal and political standards that are regulated at the EU level, and strengthen democratic values within the society.

Keywords: social sciences,juridical sciences,international law,european law,comparative law,political sciences,international organisations,human rights,responsibility,international tribunals,immunities
Trade between Spain and the Habsburg Monarchy (1725-1815): Merchant Networks in the Mediterranean and the Atlantic (MERCHANT NETWORKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2015-01-31
Duration (months): 24.0
Total project cost (EUR): 176053.2
EU funding (EUR): 176053.2
Participants: 1
Project status: CLOSED

The research project investigates the integration of continental European regions into global exchange processes taking the Habsburg Monarchy’s trade with Spain in the 18th century as example. Therewith, this project contributes to a recent research trend which focuses on the entanglement of so-called “landlocked” European territories into maritime long-distance trade having been blinded out so far. This has a specific relevance with regard to the Habsburg Monarchy. In the context of two different developmental paths both empires' economies took in the course of the transformations in the 18th century, the impact of bilateral trade on economic development will be highlighted by focusing on trans-national and trans-imperial merchant networks which connected different spaces and economic systems with each other. Connections between different merchants’ groups, the impact of family relations, the links with state institutions, i.e. lobbying, and production are conceived as explanatory factors of business performance and trans-regional entanglement. Research focuses on those merchants who mediated Spanish-Habsburg trade at four port cities: Cádiz, Barcelona, Livorno and Trieste. The time span of the project sets in with the conclusion of the Treaty of Vienna in 1725 and ends after the termination of the Napoleonic Wars. Methodologically, biographic, business and fiscal data will be collected in a database and processed by the Ucinet network analysis programme. The data derive from various sources, mainly from notary files stored at the provincial archives in Cádiz and Barcelona as well in the State Archives of Trieste and Florence. Further data are to be obtained from tax lists stored at the Archivo General de Indias in Seville and court files of the Catalan Commercial Court stored at the Archivo de la Corona de Aragón in Barcelona.

Keywords: economic history,social history,modern history,political history,international trade,merchant communities,mediterranean,18th century,spain,habsburg monarchy
Investigating how pathogen effector recognition by plant resistance proteins activates defence (PLANT-DEF-MECH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-31
End date: 2014-05-30
Duration (months): 24.0
Total project cost (EUR): 278807.4
EU funding (EUR): 278807.4
Participants: 1
Project status: CLOSED

Plants can perceive attacking pathogens via the recognition of conserved Pathogen Associated Molecular Patterns (PAMPs) resulting in activation of a multi-level plant defence. Pathogens have evolved mechanisms to attenuate PAMP-triggered immunity (PTI) via specialized “effector” proteins translocated to the host cell. Effectors can influence diverse host cell pathways in order to manipulate the cell metabolism for the benefit of the pathogen. However, plants have involved specific resistance (R) proteins for pathogen effector recognition, which initiates strong defence culminating in a localized hypersensitive cell death response (HR), restricting pathogen spread (Effector Triggered Immunity, or ETI). Although PTI and ETI result in similar responses, the links between PTI and ETI remain obscure. The study of R protein recognition and signaling requires a well-established model system. The Arabidopsis thaliana resistance genes RRS1 and RPS4, encode TIR-NB-LRR proteins which confer resistance to baterial pathogens carrying the effector genes popP2 and avrRps4 respectively. The overall aim of this proposal is to enhance our understanding of defence activation during ETI, and possible overlaps with PTI, by understanding the mechanisms of R-effector recognition and how this signals various defence responses. The work is strategically relevant as it aims to underpin the delivery of sustainable immunity in important crop species.

Keywords: natural sciences,plant defense,effector proteins,eti,pti
Delayed Luminescence Spectroscopy of Organic Photovoltaic Systems (DELUMOPV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-16
End date: 2014-05-15
Duration (months): 24.0
Total project cost (EUR): 185763.6
EU funding (EUR): 185763.6
Participants: 1
Project status: CLOSED

This project aims to accomplish an understanding of the processes that currently limit the power conversion efficiency of solution-processed organic photovoltaic (OPV) devices, by identifying the factors that are responsible for the losses in device photocurrent generation. In particular, attention will be given to the origin of the photocurrent generation losses in OPV devices that take place due to the recombination of free charge carriers, prior to charge collection at the device electrodes. For the realization of the study a new set of non-fullerene based perfluorinated materials will be used as electron-acceptors and commercially available polymeric matrices such as poly(fluorene)-copolymers and poly(thiophene)s will be used as electron-donors. Free carrier recombination in the fabricated OPV layers and in their devices will be monitored by the detection of delayed luminescence in the μs – ms time scales, as a function of the photoactive layer morphology. The resulting luminescence dynamics will be then correlated to the photocurrent generation efficiency of the corresponding OPV devices and to the charge transport capabilities of the OPV layers. The project aims to deliver a new insight on the nature and the dynamics of charge transfer excited states that survive at delayed times after photoexcitation (delxplexes) in photoactive donor/acceptor composites. Throughout the project the photophysical and electrical characterization of next generation electron-acceptor materials will be realized and this will contribute in the progress of the OPV research field. The significance of the proposed project stems from the high potential of organic semiconductors to produce inexpensive and efficient photovoltaic systems. The project will mutually benefit the applicant and the Host Institution by supporting a smooth exchange of knowledge, by integrating their different expertise on the field of organic semiconductors and by accelerating the applicant's research career.

Keywords: photovoltaics,pv materials,molecular electronics,charge transfer,nanodevices,spectroscopy,chemical physics,photochemistry,physics of semiconductors,solid state physics,experimental physics
Protein-Repellent Polymers (POLYPROT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-02
End date: 2014-04-01
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

Protein adsorption to material surfaces causes problems in numerous technological and medical applications. A favoured approach in order to prevent protein adsoprtion is to decorate surfaces with brushes of terminally anchored, neutral water soluble polymers (NWSP). But despite the great importance of NWSP-functionalization in medicine and technology, the interaction of proteins with NWSP is not fully understood. In particular, little is known about the mechanisms responsible for regularly observed "brush failure", where protein adsorption occurs despite NWSP functionalization. Here, we propose a systematic investigation of this phenomenon on a detailed structural level. Proteins interacting with NWSP-decorated surfaces of defined characteristics (i.e., polymer length and grafting density) will be localized using the combination of two sophisticated scattering techniques: 1) Neutron reflectometry (NR) with contrast variation. 2) Standing-wave x-ray fluorescence (SWXF). Both techniques possess un-matched spatial resolution and unique, yet complementary, chemical sensitivity. Their combination will reveal the contribution of different interaction modes of proteins with NWSP-decorated surfaces on a quantitative level. The results will provide an invaluable basis for the "rational design" of protein-repellent surface functionalization.

Keywords: molecular biophysics,experimental physics,soft matter and polymer physics,radiation physics,neutron physics,surface physics
Decoding the conodont fossil record through analysis of function in ontogeny and phylogeny (CONODONT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-01-01
End date: 2014-12-31
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Conodonts are extinct primitive vertebrates that attract widespread interest because of the insight they provide into the earliest vertebrate skeleton which they manifest as the mineralized ‘elements’. These teeth dominate a fossil record that is among the richest and most complete. To date, this record has been exploited successfully but solely for its biostratigraphic significance; the evolutionary significance of lineages, reconstructed through biostratigraphy, has not been realised because the tooth function of conodont elements has been determined only very recently. It is my aim to draw together these two strands of research, using state of the art methods of synchrotron radiation x-ray tomographic microscopy to uncover the ontogeny of occlusal elements and derive digital models using computed tomography that will be subject to virtual occlusal modelling to inform loads in FE Analyses of element function. Predictions from FEA will be tested using microwear and mesowear analyses characterised using optical profilometry, and through EBSD analysis of element microstructure. This seminal study will revolutionise both our understanding of the conodont fossil record – the role of intrinsic innovation versus extrinsic forces of competition and environmental change, it will also establish an entirely new suite of investigative tools to the discipline. The study will also demonstrate the importance of biostratigraphic and taxonomic data and how it is possible to integrate traditional and state of the art approaches in a world-class research programme. BROADER IMPACT: Evolutionary developmental biologists interested in the primitive vertebrate skeleton and isotope geochemists interested in the use of conodont apatite as a proxy for seawater chemistry in deep time, together facilitating a new vista of research integrating evolutionary patterns, feeding ecology and environmental variations revealed in seawater chemistry.

Keywords: paleobiology,early vertebrates,phylogeny
UNIQUE gasifier for hydrogen Production (UNIFHY)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Italy,Italy,Netherlands,France,France,Germany,Germany
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-09-01
End date: 2016-03-31
Duration (months): 43.0
Total project cost (EUR): 3433606.9
EU funding (EUR): 2203599.0
Participants: 9
Project status: CLOSED

Through development and scale up activities on materials and reactors for the integration of advanced biomass steam gasification and syngas purification processes, UNIfHY aims to prove from a process, pilot and industrial scale point of view continuous pure hydrogen production from biomass, increase well-to-tank efficiency and contribute to a sustainable energy portfolio, exploiting results achieved in past R&D EU projects on hot gas catalytic conditioning. The project is based on the utilization of plant components of proven performance and reliability and well established processes (UNIQUE coupled gasification and gas conditioning technology, Water-Gas Shift, WGS, system and Pressure Swing Adsorption, PSA, system), thus targeting up to 20 years plant durability with availability>95%. The project benefits from the already existing laboratories and UNIQUE gasifiers in order to maximize results (technology development at process-, system- and industrial-scale) with minimum risk and budget requirement (laboratories, pilot and industrial gasifier already available). Indirectly heated (100 kWth) and oxygen (1 MWth) steam fluidized bed gasifier power plants are tested without and with hot gas condition systems, meanwhile new materials for atmospheric pressure WGS are realized and utilized to develop a WGS reactor, that together with a ZnO reactor to reduce the sulphur compounds will be integrated with a tailored PSA in a portable purification unit, connected downstream the 1 MWth gasifier in order to yield pure hydrogen. The result will be the assessment of the two UNIfHY technologies (indirectly and oxygen gasifiers coupled to the Portable Purification Unit) for continuous production of hydrogen (up to 500 kg/day). The huge experimental and process/system simulations activities encompass also related routes (different catalysts, also sorbents, etc.) in order to evaluate different paths and reach, at least at simulated system level, global conversion efficiency in hydrogen up to about 70%. Finally, owing to the high level of thermal, chemical and plant integration (tar and methane reforming and particulates abatement carried out directly in the gasifier freeboard, reuse of purge gas in the process, etc.), the reduction of space and components and the investment cost savings are expected to be about 50%, bringing to a hydrogen production cost of about 5€/kg.

Keywords: biomass,hydrogen,gasification,unique technology,catalyst,sorbent,wgs,psa
Benchmarking Integrated Care for better Management of Chronic and Age-related Conditions in Europe (PROJECT INTEGRATE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Spain,Spain,Netherlands,Germany,Sweden,Norway,Belgium,Estonia,Switzerland,Netherlands
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 3676649.0
EU funding (EUR): 2898468.0
Participants: 10
Project status: CLOSED

INTEGRATE aims at gaining valuable insights into integrated care, starting from the premise that it offers benefits for patients and for Europe’s health and social security systems, which are facing the challenges of an ageing population and increased chronic conditions. For these benefits to be realised, there is still much to be learnt in terms of process design, service delivery, skills mix, patients’ involvement, funding flows, regulatory conditions, and enabling information technologies to create connectivity, alignment and collaboration within and between the cure and care sectors. INTEGRATE will look into best practices of integrated care that have a proven impact in terms of positive patient care experiences; care outcomes and cost-effectiveness. The key aim is to define what constitutes good quality integrated care provision. By studying real case studies considered to be examples of interesting integrated approaches to medical care and a defined set of horizontal issues across different European health systems, we will identify generic success factors of care integration, taking into account context dependency. The results will be contrasted with international evidence and feed into operational and policy recommendations. INTEGRATE brings together a multi-disciplinary team with extensive knowledge of the challenges involved in promoting integrated care, drawing on financial, regulatory, human resources, technological, and managerial perspectives, covering very different European settings, including a new Member State, building on existing collaborative relationships. To ensure scientific coherence and maximise the chances of achieving effective policy change, INTEGRATE builds on the strong, existing network of IFIC (International Foundation of Integrated Care). INTEGRATE will impact on European health policies by providing managerial and policy recommendations, based on evidence from successful integrated care experiences, with the aim to support health providers and Member States in better organising health care and systems.

Keywords: integrated care,health care,process management,financial flows,skills mix,patient involvement,information technology,active-healthy ageing,diabetes,copd,mental health,geriatric conditions.
Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,Sweden,Italy,France,Germany,Netherlands,United Kingdom
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2012-12-01
End date: 2017-11-30
Duration (months): 60.0
Total project cost (EUR): 8260833.6
EU funding (EUR): 6000000.0
Participants: 16
Project status: TERMINATED

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials needed. This proposal builds upon previous EU funded pre-clinical projects and comprises a multidisciplinary and translational research group with wide-ranging relevant expertise. Building on encouraging clinical results targeting NY-ESO-1 in melanoma and the availability of clinical grade vector, the consortium proposes to rapidly initiate two landmark studies in this field: the first to examine the activity of engineered T cells in oesophago-gastric cancer as an example of a hard to treat common epithelial cancer; the second to undertake a randomised phase II study to determine whether an optimised cell production system developed by the partners improves the current clinical response rates in patients with metastatic melanoma treated with NY-ESO-1 targeted T-cells. Success in these trials will enable the consortia and others to carryout larger trials and potentially approval of this type of therapy as a treatment for multiple cancer types. The inclusion of a major industrial partner focused on cell therapy technology and two SMEs focus on the delivery of cell therapy will facilitate future development of this area following these trials; indeed the project also includes plans to further automate and streamline cell processing to facilitate this development. This project would enhance European expertise and competitiveness in an important emerging market. The research will also support the European biotechnology industry which will be important for the exploitation of these therapies and the successful outcome of this project.

Keywords: ny-eso1,adoptive cell therapy,engineered t-cells,cytokines,in vitro manipulation,immune regeneration,cancer auto immunity