Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of Evasive Resistance in Cancer (MERIC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Synergy grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland
Call:  (ERC-2013-SyG, 2013)
Start date: 2014-05-01
End date: 2020-04-30
Duration (months): 72.0
Total project cost (EUR): 11197882.0
EU funding (EUR): 11197882.0
Participants: 3
Project status: CLOSED

Cancer is a major health problem due to the failure of current therapies to effectively eradicate the disease. Alternative signaling pathways compensate for a therapeutically targeted pathway, a process referred to as 'evasive resistance'. The identities of the alternative signaling pathways and functional interconnections that underlie evasive resistance remain widely unknown. We propose to integrate cutting-edge clinical, molecular, and computational sciences to understand the signaling defects that allow tumors to evade therapy. With its synergistic, interdisciplinary approach, the proposed project is, to our knowledge, unique in Europe and possibly worldwide. Within the framework of rigorously designed clinical studies, a clinician will provide basic research scientists with diseased tissue isolated before therapy, during treatment or at the time of tumor progression. The tissue, chosen based on medical importance, accessibility to repeated sampling, and ethical considerations, will be from hepatocellular carcinoma. Tumor tissue will be obtained by needle biopsy and snap frozen to preserve in vivo properties. The basic research scientists and a computational biologist will determine, characterize and model the underlying signaling defects. Importantly, using longitudinal clinical samples in combination with mouse and cellular HCC model systems, we will seek to define treatment-related changes in cell signaling that allow tumors to circumvent therapy. This process will be iterative such that changes in treatment strategies will again be monitored in the same patient or experimental model. Insights gained will be used (i) to understand mechanisms of evasive resistance, (ii) to identify novel drug targets and predictive biomarkers, and (iii) to rationally design personalized medicine that ultimately increases therapeutic effectiveness and reduces financial burden. This innovative, comprehensive endeavor will improve diagnosis, treatment and clinical outcome.
RESEARCHERS NIGHT 2013: Researchers on and off work (LT2013)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Lithuania,Lithuania,Lithuania,Lithuania
Call:  (FP7-PEOPLE-2013-NIGHT, 2013)
Start date: 2013-05-01
End date: 2013-09-30
Duration (months): 5.0
Total project cost (EUR): 71566.12
EU funding (EUR): 65000.0
Participants: 10
Project status: CLOSED

The LT2013 Researchers Night will take place in Lithuanian major cities, i.e. Vilnius, Kaunas, Klaipeda, Siauliai, Panevezys and Moletai, as well as in remote rural areas. The project aims to enhance public recognition of researchers and their work through bringing scientists and public closer to one another and through exploration of researchers interests, hobbies and other occupations beside their primary research work. The event will offer a broad range of varied activities addressing all categories of the public at large, regardless of age and scientific background, i.e. notably: Meetings and activities with researchers; Lectures, discussions; Visits to open laboratories; Real life observations and experiments; European corners; Various contests, movie and online broadcast watching; Broadcasting online. All the activities planned will actively involve researchers and will offer a balanced combination of "serious" activities and fun ones. Activities will be hosted in labs, lectures halls, meeting places, while in the rural areas they will take place in schools or public spaces. Some activities conducted in the main site will be broadcasted on line.

Keywords: researchers work and life,activities with researcher,science,broadcasting online,main cities and rural areas,science and society
SHARP, Sharing Researchers' Passions - Umbria Researchers' Night 2013 (SHARP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-NIGHT, 2013)
Start date: 2013-05-01
End date: 2013-11-30
Duration (months): 7.0
Total project cost (EUR): 108258.4
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

SHARP stands for Sharing Researchers’ Passions and is the name of the first European Researchers’ Night in Umbria, a region in the centre of Italy, a long night with researchers that will take place on the 27th of September 2013. Locations for the event will be the three Umbria main cities: Perugia, Terni and Foligno, where departments of the 700 year old University and public and private research centres are located. Piazzas, streets, characteristic corners and unusual location will be the backdrop to meet researchers. With a curious public entering into the spirit of original and lively performances will be easy to bridge the gap that many times separates the researchers’ world and the general public. SHARP activities will engage the public to identify shared passions, attitudes, expectations and way of thinking they have in common with the researchers. 24 different activities arranged in 39 events proposed during the Night will be inspired by passions for music, sport, arts, cooking, tv, movies, games. Events will help to present the researchers' work in various cutting edge research fields. SHARP night will present researchers as passionate people, with passions about the real world we all live in. Passion is also a key for motivation and commitment, a relevant message that will be covered to youngster. Passions are definitely a shared ground among humans. Sharing passion is a form of dialogue that helps to better recognize the researchers’ role.

Keywords: researcher night passions fun motivation research science technology commitment fun ideas european corner sport cooking music theatre game show laboratories interaction social linkage viral
Frontiers in Attosecond X-ray Science: Imaging and Spectroscopy (AXSIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Synergy grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2013-SyG, 2013)
Start date: 2014-08-01
End date: 2020-07-31
Duration (months): 72.0
Total project cost (EUR): 13884200.0
EU funding (EUR): 13884200.0
Participants: 2
Project status: CLOSED

X-ray crystallography yields atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes constituting the macromolecular machinery of life. Life is not static, and many of the most important reactions in chemistry and biology are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by ultrafast laser spectroscopy, but they reduce the vast complexity of the process to a few reaction coordinates. Here we develop attosecond serial crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology. We apply a fully coherent attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, developed in this project, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals [A. Cho, "Breakthrough of the year", Science 388, 1530 (2012)]. Our synergistic project will optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. The multidisciplinary team optimizes X-ray pulse parameters, in tandem with sample delivery, crystal size, and advanced X-ray detectors. We will apply our new capabilities to one of the most important problems in structural biology, which is to elucidate the dynamics of light reactions, electron transfer and protein structure in photosynthesis. Also, the attosecond source can provide a coherent seed and will help to overcome peak flux limitations of X-ray FELs by introducing chirped pulse amplification to FEL technology.

Keywords: compact x-ray source
Marine Exploring Researchers (MAREXPRES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Greece
Call:  (FP7-PEOPLE-2013-NIGHT, 2013)
Start date: 2013-05-01
End date: 2013-11-30
Duration (months): 7.0
Total project cost (EUR): 35887.2
EU funding (EUR): 31999.42
Participants: 2
Project status: CLOSED

The National and Kapodistrian University of Athens in collaboration with the Hellenic Oceanographers’ Association aim to undertake ‘Marine Exploring Researchers’ (MAREXPRES) on Friday 27th September 2013, in the framework of ‘Researchers’ Night 2013’, under the scope to enhance public recognition of researchers across Europe. Therefore, the consortium intends to hold an outdoor event in The Old University in Plaka, one of the most attractive locations of Athens. MAREXPRES will try to communicate to the general public that researchers are ordinary individuals capable of socially interacting, whose profession is both challenging and fascinating. During the event the researchers will present some of the broad applications of Marine Sciences and their research trying to highlight that ocean exploration is useful to the society and improves our life. There will be an interdisciplinary approach by biologists, chemists, geologists and physicists, members of UOA laboratories and HOA, in a comprehensible yet scientific and festive way, with researchers acting as guides, animators, and coordinators. MAREXPRES will try to achieve a mass participation, addressing an audience of mixed age categories and backgrounds, giving the public the opportunity to frequent scientists in diverse circumstances, different from those usually anticipated. In addition, MAREXPRES will point out that European citizens can be EU support beneficiaries, such as of Marie Curie actions. The activities of the event, which will be of both scientific and entertaining nature and try to satisfy a broad spectrum of interests, will be planned and implemented by researchers of all levels. All the presentations, simulations and activities will expose attendees to ocean exploration and will try to set them in the shoes of researchers. Therefore, the MAREXPRES project aspires to constitute a central massive event.

Keywords: marine researchers,ocean exploration,researchers-guides/animators,simulations,presentations,quizzes,festivities,athens,the old university,european mobility.
Discover Research Night 2013 (DISCOVERRESEARCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Ireland
Call:  (FP7-PEOPLE-2013-NIGHT, 2013)
Start date: 2013-04-14
End date: 2013-11-13
Duration (months): 7.0
Total project cost (EUR): 118249.2
EU funding (EUR): 90000.0
Participants: 2
Project status: CLOSED

Discover Research Night 2013: Trinity College Dublin (TCD), in partnership with the Royal Irish Academy (RIA) as the Digital Repository of Ireland (DRI), is seeking funding to plan, promote and host the Discover Research Night as part of European Researchers' Night 2013. The project will present the public in Dublin and beyond with an opportunity to discover and celebrate the work of TCD and DRI researchers. The team of researchers will organise a range of fun, hands-on and interactive activities for the public to participate in side-by-side with the researchers. The General Theme of the Discover Research night is to involve the public in a night of fascinating research activity, linking history and the arts to technology, science and digital media. Some of the specific activities to be made available by the researchers themselves include a projection of the Sun at Night by astrophysicists, "Tag You're It!" where participants can label and "tag" their favourite cultural heritage objects, "CURATE-athon" where the audience writes the news for the night and the "First World War digital experience". TCD and the DRI will host Discover Research Night as part of a cross-European event on the 27th September 2013 and the activities are planned for various locations both within the TCD campus, the RIA and other off-campus locations in Dublin City Centre. TCD and the RIA have prepared this project proposal, in accordance with the Guidelines for Applicants and this proposal outlines the proposed project management structure, the work programme for the proposed 7 month time-line and the proposed budget for carrying out the relevant tasks. Trinity College Dublin and the Royal Irish Academy aim for Discover Research Night to be the first EU Researchers' Night to be held in Ireland's capital city, Dublin.

Keywords: researchers,trinity college dublin,digital repository of ireland,public awareness,research activities,impact assessment,science,computer science,digital humanities,historical research
Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Synergy grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2013-SyG, 2013)
Start date: 2014-06-01
End date: 2020-05-31
Duration (months): 72.0
Total project cost (EUR): 12272645.15
EU funding (EUR): 12272645.0
Participants: 2
Project status: CLOSED

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is established and maintained is still unclear. The aim of this project is to explore whether the genome 3D structure acts as an information source for modulating transcription in response to external stimuli. With a genuine interdisciplinary team effort, we will study the conformation of the genome at various integrated levels, from the nucleosome fiber to the distribution of chromosomes territories in the nuclear space. We will generate high-resolution 3D models of the spatial organization of the genomes of distinct eukaryotic cell types in interphase to identify differences in the chromatin landscape. We will follow the time course of structural changes in response to cues that affect gene expression either permanently or transiently. We will analyze the changes in genome structure during the stable trans-differentiation of immortalized B cells to macrophages and during the transient hormonal responses of differentiated cells. We plan to establish novel functional strategies, based on targeted and high-throughput reporter assays, to assess the relevance of the spatial environment on gene regulation. Using sophisticated modeling and computational approaches, we will combine high-resolution data from chromosome interactions, super-resolution images and omics information. Our long-term plan is to implement a 3D browser for the comprehensive mapping of chromatin properties and genomic features, to better understand how external signals are integrated at the genomic, epigenetic and structural level to orchestrate changes in gene expression that are cell specific and dynamic.

Keywords: genome architecture
La Noche de los Volcanes – an awareness raising Night for the work of volcanologist and geologist scientists II. (VOLCANOES NIGHT 2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain,Spain
Call:  (FP7-PEOPLE-2013-NIGHT, 2013)
Start date: 2013-05-01
End date: 2013-11-30
Duration (months): 7.0
Total project cost (EUR): 40948.0
EU funding (EUR): 40000.0
Participants: 2
Project status: CLOSED

People have been fascinated by volcanoes ever since the dawn of mankind and treated them with utmost respect. The rapid development of converging technological areas, such as informatics, material science or space research multiplied our knowledge of earth processes and created some highly specialised fields within volcanology. At the same time a dramatic gap has formed between the professionals and the public. As a result, in today’s world, the work of volcanologists is nearly as mythical as the work of volcanoes in ancient times. The objective of this project is therefore to address this issue and bridge the gap between science and the general public of different ages, by means of a tailored dissemination campaign that will reach its peak on 27 September 2013, when Volcanoes’ Night II. will be organised. The Night will cover four islands of the Canary Archipelago, namely: Tenerife, Lanzarote, El Hierro and La Palma. These locations are chosen for a single reason: they all have had active volcanism in recorded history from the first reports since the Spanish conquerors arrived to the archipelago, to the last, submarine eruption at El Hierro island in October 2011. Lanzarote suffered the longest eruption ever documented in the Canary Islands, from 1730 to 1736. Tenerife has had 6 eruptions, including one observed by Christopher Columbus back in 1492. La Palma has the biggest number of eruptions, with two of the most famous/recent ones, San Juan (1949) and Teneguía (1971). These historical eruptions will serve as a backdrop for Volcanoes’ Night II, during which access will be provided to research facilities, and a complementary scheme of workshops, science cafés, excursions, presentations and challenge games will be arranged all to fuel the public’s curiosity, interest and understanding of research activities. Volcanoes will be used as a backdrop to explain the work of scientists in general and the work of volcanologists/geologists in particular.

Keywords: geology,volcanology,geoscience,environment,earth,volcanoes,public awareness,science
Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies (HELMHOLTZ)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Synergy grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2013-SyG, 2013)
Start date: 2014-08-01
End date: 2020-07-31
Duration (months): 72.0
Total project cost (EUR): 11861923.0
EU funding (EUR): 11861923.0
Participants: 2
Project status: CLOSED

The HELMHOLTZ project associates two leading neighbouring institutions: the Institut de la Vision (Fondation Voir et Entendre) and the Institut Langevin (Fondation Pierre-Gilles de Gennes) committed to boost the integration of technological research in photonics, acoustics and ultrasound with translational research on vision impairment, in order to co-develop and validate prototypes for non-invasive in vivo structural and functional dynamic imaging technologies for ophthalmology. Innovative imaging tools will rely on emerging concepts such as ultrafast ultrasound, laser Doppler holography, full field and ultrafast cell resolution optical coherence tomography (OCT), bi-photon microscopy. These will enable both structural and functional analyses of the ocular tissues, with strong focus on the macula, the central part of the retina which is affected by the most severe disabling conditions, e.g. retinal dystrophies, age-related macular degeneration, glaucoma, vascular diseases, diabetic retinopathy, toxicities. We shall explore: 1) the subcellular and dynamic structure of photoreceptors, 2) changes in vascular flow and 3) functional imaging of the visual system from retina to cortex. Massive data acquisition and ultrafast numerical signal processing will take advantage of GPU-based parallel computing and of new asynchronous visual sensors. Continuous feedbacks from animal and human studies will lead to refine or redefine the prototypes jointly. These new diagnostic tools will address unmet medical needs by improving the understanding of retinal pathophysiology, defining new biomarkers for disease progressions and enabling clinicians to select the best suited emerging therapies, from neuroprotection to gene therapy and visual restoration. As the most optically and functionally approachable part of the brain, the retina will thus exemplify and validate major streams of technological innovations for care by enhancing cross-fertilization between biomedicine and physics.

Keywords: physics - light - sound - imaging - sensory impairment - neurosciences - ophthalmology
Spin-charge conversion and spin caloritronics at hybrid organic-inorganic interfaces (SC2)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Synergy grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom,United Kingdom,Czechia,Germany,United Kingdom
Call:  (ERC-2013-SyG, 2013)
Start date: 2014-08-01
End date: 2020-07-31
Duration (months): 72.0
Total project cost (EUR): 9651487.0
EU funding (EUR): 9651487.0
Participants: 5
Project status: CLOSED

Organic semiconductors are enabling flexible, large-area optoelectronic devices, such as organic light-emitting diodes, transistors, and solar cells. Due to their exceptionally long spin lifetimes, these carbon-based materials could also have an important impact on spintronics, where carrier spins, rather than charges, play a key role in transmitting, processing and storing information. However, to exploit this potential, a method for direct conversion of spin information into an electric signal is indispensable. Spin-charge conversion in inorganic semiconductors and metals has mainly relied on the spin-orbit interaction, a fundamental relativistic effect which couples the motion of electrons to their spins. The spin-orbit interaction causes a flow of spins, a spin current, to induce an electric field perpendicular to both the spin polarization and the flow direction of the spin current. This is called the inverse spin Hall effect (ISHE). We have very recently been able to observe for the first time the inverse spin-Hall effect in an organic conductor. This breakthrough raises important questions for our understanding of spin-charge conversion in materials with intrinsically weak spin-orbit coupling. It also expands dramatically the range of materials and structures available to address some currently not well understood scientific questions in spintronics and opens opportunities for realising novel spintronic devices for spin-based information processing and spin caloritronic energy harvesting that make use of unique properties of hybrid, organic-inorganic structures. The main objective of the proposed research is to take spintronics to a level that inorganic spintronics cannot reach on its own. The project is based on new theoretical and experimental methodologies arising at the interface between two currently disjoint scientific communities, organic semiconductors and inorganic spintronics, and aims to exploit synergies between chemistry, physics and theory.