Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
InnoBremen2 – Establishing services enhancing the innovation management capacities of SMEs in the Federal State of Bremen (InnoBremen2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 57082.5
EU funding (EUR): 57082.5
Participants: 3
Project status: CLOSED

The following proposal addresses the topic “Specific activities in the context of innovation support (Horizon 2020)“, namely the in-depth services enhancing the innovation capacity of SMEs, i.e. “Key account management under the SME Instrument of Horizon 2020” and “Services to enhance the innovation management capacities of SMEs”. Innovation is a key driver for the success of enterprises, a requirement for their competiveness and thus a precondition for exploiting international opportunities in the Single Market and beyond. Offering growth-oriented business and innovation support services to SMEs is therefore seen as the core task of the Enterprise Europe Network. Although Innovation Management is crucial for SMEs, empiric data has proven that SMEs still show the inability to manage innovation processes efficiently and effectively as the second most important barrier to SME innovation. Enterprise Europe Network Bremen will offer the services - Key account management under the SME Instrument of Horizon 2020 and - Services to enhance the innovation management capacities of SMEs as an integral part of the Enterprise Europe Networks services addressing the innovation needs of SME’s to establish an Innovation Management System (basis: technical specification CEN/TS 16555-1, published by the European Commission) in the respective enterprises. Beneficiaries of the services will be: 1. Beneficiaries of the SME Instrument 2. SMEs with significant innovation activities and a high potential for internationalization namely by offering the provision of innovation and technology audits and technology transfer partnering services.

Keywords: innovation capacity,innovation management,innovation services,kam services,sme instrument
Spectroscopy in cells with tailored in-vivo labelling strategies and multiply addressable nano-structural probes (SPICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-11-30
Duration (months): 78.0
Total project cost (EUR): 1988697.5
EU funding (EUR): 1988697.5
Participants: 1
Project status: SIGNED

This project proposes to combine complementary spectroscopic approaches and push the domain of molecular spectroscopy for structural biology and biophysics into the living cell. Non-invasive molecular spectroscopy to probe protein dynamics and structures at the molecular level is essential for unravelling one of the most challenges in Chemical Biology - the complex physical mechanism of life. Of particular interest are electron paramagnetic resonance (EPR) distance measurements in the nanometer range, especially, when they will be combined with complementary spectroscopic techniques. By now, different spectroscopic approaches require specific labelling strategies and probes. In this project, we will develop multiply-addressable nano-structural probes that are in parallel suitable for various spectroscopic techniques, e.g. magnetic resonance spectroscopy (NMR and EPR), vibrational spectroscopy, and optical (including single molecule) spectroscopy and microscopy. This enables obtaining information on all relevant length and time scales for the very same sample. Labelling will be performed directly in the native intracellular environment, where the proteins are folded, modified, transferred and degraded. Corresponding spectroscopic experiments can be combined or re-arranged for novel experiments even in cellula. Current characterization methods for structure and dynamics of proteins are generally applied in vitro. In the cell, posttranslational modifications, crowding effects, organelle specific localization, or non-specific or specific interactions with cellular components significantly affect structure and conformational equilibria of proteins. We will demonstrate that novel in-cell spectroscopy approaches developed within the SPICE-project using multiply-addressable nano-structural probes and in vivo labelling strategies will open up possibilities to explore larger and more complex biological structures at the molecular level in cellula, which has hitherto been

Keywords: electron paramagnetic resonance spectroscopy
High-Frequency Spin Entanglement Generation in Diamond (Hi-FrED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

This proposal promotes a research program in quantum nano-photonics to be carried out by dr T. Jakubczyk. It aimes at achieving high frequency of generation and detection of spin-spin entanglement in spatially separated nitrogen vacancy (NV) centers in diamond. While current photon collection efficiencies (few per cent) and entanglement rates (approx. one entanglement event per minute) may be sufficient for proof-of-principle experiments, they need to be greatly improved for the implementation of practical quantum networks. The project builts on a recent progress achieved in the host institution in the deterministic cavity-assisted enhancement of the coherent photon emission rate of NV centers embedded in a diamond membrane. The increase of the decay rate results in enhanced radiative efficiency and makes the emission robust against dephasing enhancing the photon indistinguishability and boosting the photon extraction efficiency. The aim of the project is to establish the NV center as spin- and optically- coherent, specifically by decreasing the linewidth broadening resulting from the minimal necessary processing of the diamond crystal and introducing significant improvements to the cavity. The estimated resulting spin-spin entanglement rates are in the Mhz-range. The projects opens new ways of studying complex and non-trivial phenomena resulting from the enhanced light-matter coupling in the NV center and in other quantum emitters. Success of this project may provide a route to the realisation of scalable quantum computers based on optical networks of electronic and nuclear spins.

Keywords: nitrogen vacancy centers,open cavities,spin,entanglement
The molecular basis and genetic control of local gene co-expression and its impact in human disease (CODer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

The genetic makeup intrinsic to each person shapes their particular traits, disease susceptibilities and treatment effectiveness, making understanding the functional impact of genetic variants one of the most pursued challenges in genetics research. Genome-wide association studies (GWAS) have so far associated >10,000 genetic variants with disease, with expression quantitative trait loci (eQTL) studies adamant in linking some of these disease variants to causal genes. Yet, understanding a variant’s molecular link to disease is still a major challenge, given that most are found in the genome’s non-coding regions, act only in specific tissues and may affect several genes. Recent studies revealed that neighbouring genes are often co-expressed – forming co-expression domains (CODs) – potentially regulated by shared regulatory variants, yet, this has been ignored in eQTL and GWAS studies. This project aims to investigate how local gene co-expression is achieved and regulated by genetic variants, and their impact on human disease. For this, I propose a novel genome-wide framework to detect human CODs and their regulatory variants (cod-QTLs) using transcriptomic profiles across hundreds of genotyped individuals. The mechanisms through which variants affect the expression of several genes will be discovered through causality inference and molecular characterisation using state-of-the-art datasets (e.g. Hi-C, promoter-enhancer maps). Notably, CODs’ tissue-specificity will be studied using gene expression across 53 human tissues and the co-expression variation across 120 individuals will be assessed using a cutting-edge dataset of single-cell RNA-seq. The impact of cod-QTLs on dozens of societal-relevant diseases will be determined by colocalization analysis with GWAS hits from the UK Biobank. This project promises to clarify fundamental aspects of gene (co-)regulation and provide functional interpretation of eQTLs and GWAS findings, including revealing novel disease genes.

Keywords: local gene co expression,gene expression regulation,expression quantitative trait loci analysis,gwas colocalization analysis,genetic effect propagation,tissue specificity,single cell rna seq
Global Citizenship Law: International Migration and Constitutional Identity (GlobalCitizenshipLaw)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1499588.0
EU funding (EUR): 1003843.0
Participants: 2
Project status: CLOSED

Managing global migration is one of the most pressing issues of our time, particularly in Europe. With more than 230 million international immigrants, the manner in which new citizens are/should be "created" has become a controversial issue, morally and politically. Traditionally, international law has not regulated nationality law; naturalization requirements remain the last stronghold of national sovereignty. This project advances the establishment of a new subfield in public international law—International Citizenship Law (ICIL)—which would regulate nationality law. It asks a critical and timely question: what are/should be the international legal limitations/privileges imposed on/granted to states in setting naturalization requirements? In order to address this question, the project has five scientific objectives: [1] to investigate the history of the law of naturalization in international law and what it can teach us about 21th-century challenges; [2] to identify the most recent legal developments in the field of naturalization law and establish the most up-to-date international legal standards of naturalization law; [3] to set out the theoretical foundations and the justifications for the establishment of ICIL; [4] to analyze the normative and structural implications derived from an-ICIL approach for future citizenship policy development, as well as to identify the legal reforms that should be taken to promote an-ICIL approach; and [5] to explore the interrelationship between ICIL, immigration policy, and constitutional identity. In essence, the project seeks to formulate international legal standards by which states can admit immigrants without fundamentally changing their cultural heritage and slipping into extreme nationalism. The outcome can serve as a basis for a future reform in international law, EU law, and national legal systems. As the immigration debate reaches a decisive moment, this project has both theoretical significance and policy implications

Keywords: constitutional identity,international citizenship law,comparative immigration law,naturalization,the study of nationalism,citizenship theory,immigrant integration,national belonging
Building an Evidence-Base for Reducing Gender Bias in Educational Pathways (GirlsInScience)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-09-30
Duration (months): 64.0
Total project cost (EUR): 1999342.0
EU funding (EUR): 1999342.0
Participants: 1
Project status: CLOSED

In 2012, the European Commission launched the campaign Science: It’s a girl thing!, aimed at encouraging women to choose research careers, as they are sorely underrepresented in science, technology, engineering, and mathematics (STEM). Given that gender disparities in aptitude for specific fields are generally very small, highly gendered skewness in educational choices suggest pathways dictated by stereotypes rather than abilities, leaving valuable STEM talents unused. Many European countries have invested in boosting girls’ participation in STEM through workshops with girl-oriented science topics, contact with female role models, and information packages. However, the vast majority of these initiatives have not been scientifically evaluated. Further, most programs leave untouched one of the key underlying processes keeping girls from STEM that emerge from the research literature, namely daily socialization reinforcing gender stereotypes in the school and family context. I aim to fill this gap by developing a video-feedback intervention aimed at reducing teachers’ (largely unconscious) gendered classroom interactions in primary and secondary schools, testing its effectiveness in reducing gender disparities in STEM in a randomized control trial (RCT), and longitudinally investigating salient family processes from infancy to late adolescence to inform parent education programs. This approach is innovative because it is the first to apply and rigorously test a video-feedback intervention aimed at reducing gendered interactions in schools. Further, the comprehensive scope of the study design is unique because it includes children and adolescents across development in both the school and the family context. The insights from this study will provide new avenues for both research and practice regarding gender socialization. The project fits seamlessly with my expertise in gender socialization, and experience with longitudinal and RCT projects in schools and families.

Keywords: family,childhood,adolescence,school
Polarimetry with spatially coherent detection for ultrasensitive detection (POLARSENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2021-10-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

It has long been known that chiral objects interact asymmetrically with chiral electromagnetic fields, but chiroptical effects are typically very small because the wavelength of light is so much larger than the size of biological molecules. The POLARSENSE project proposes a new ground-breaking approach for the detection and quantification of chirality that will permit ultrasensitive chiral discrimination through optical means. Its objective will be to set up a coherent detection method that will exploit the spatial coherence of light, similarly as in double beam interferometers exploit the temporal coherence of light. Switching from temporal coherence to spatial coherence supposes a paradigm shift for the optical coherent detection technique and it will allow using a single light beam instead of having to deal with two different beams. With this new technique, two different parts of the beam will acquire different polarizations and will then recombine coherently. The formed interference pattern will depend on the optical properties of the sample, and they will be recovered after an holographic analysis. This spatially coherent detection method can be implemented in a Mueller matrix polarimeter capable of detecting minute differences of polarization states associated to chiral signals, for example during protein folding. It is envisaged that such technique will maintain the advantages of general applicability, wide spectroscopic range and low cost of the optical method of polarimetry but with a tremendous increase of its sensitivity.

Keywords: polarimetry,polarized light,light coherency,optical activity,chirality
EMBL Interdisciplinary Postdoc Programme 4 (EIPOD4)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 13240800.0
EU funding (EUR): 6620400.0
Participants: 1
Project status: SIGNED

EIPOD4 is an international postdoctoral fellowship programme embedded in the world-class research environment of EMBL. It fosters interdisciplinary and intersectorial research opportunities between academia, industry, clinics and museums via three available tracks (Academic, Industry, Clinical). The programme will host 60 experienced researchers recruited in 3 globally advertised calls following a transparent and merit-based evaluation and selection process with international peer-review. Fellows receive 3-year employment contracts to complete their self-designed interdisciplinary research projects. They develop interdisciplinary research skills and complete a mandatory training portfolio targeting transferable skills. A dedicated career development service and career secondment opportunities allow EIPOD4 fellows to further develop core competencies and enhance their networking skills. They are part of EMBL’s established Second Mentor programme and develop their own mentoring skills via the new EIPODs Inspire scheme where they support junior colleagues from less-represented countries. The programme aims to educate future scientific leaders with a strong sense of their responsibility to society. An important aspect of this is to engage in dialogue with the general public. The project partner, the Natural History Museum in London, will provide fellows with science communication training. Fellows will also have the unique opportunity to participate in one of the museum’s high profile public engagement events. EIPOD4 supports the increasing diversity of career paths in Europe’s research landscape. The programme will increase the visibility of the European Research Area as an attractive destination for experienced researchers to receive valuable and innovative training. As many of the globally recruited fellows stay in Europe following their postdoctoral fellowship they will contribute their skills to positioning Europe as a research and innovation leader.

Keywords: interdisciplinary,intersectorial,international,academia,industry,clinic,museum,research and career secondments,training and career development,open science,research integrity,public engagement
Integrating energy systems and supply chain optimisation for sustainable development: Decentralised, Energy-Leveraging Transformation of African Development (DELTADev) (DELTADev)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

This project has three core objectives: (1) It aims to place energy systems design within the context of broader sustainable development (SD). Many of the UN’s 17 Sustainable Development Goals (SDGs) are known to be closely linked to energy. This project is the first to translate this nexus into a comprehensive multi-objective optimisation framework, which explicitly considers various SDG targets as objectives when planning energy systems. (2) It intends to integrate energy systems and supply chain optimisation in a common modelling environment. Motivated by inadequate conditions for economic development in low-income countries, this allows reaping synergies from energy-enabled productivity increases across agricultural and manufacturing supply chains. (3) Combining concepts (1) and (2), it aims to develop a bottom-up strategy for rural development, tailored to energy-deprived areas in Africa. It provides affordable and scalable electricity access to foster SD without relying on excessive amounts of external finance. A multi-objective optimisation model designs off-grid energy systems based on real-world examples by using the SDGs to define objective functions. Integrating electricity as an input for existing and new rural supply chains increases the value-add per kWh. This creates new revenue streams which, crucially, can cross-subsidise non-commercial electricity needs of SD to improve the quality of life for rural Africans while the system’s remains financial viability. The MSCA fellowship allows me to focus my interdisciplinary expertise on a core research theme of sustainable operations for development. It advances my profile by capitalising on the project's opportunities for transformative research and impact. Furthermore my research, implementation and managerial skills are advanced through a close integration into Prof. Grit Walther’s research group during the fellowship and a firm dedication to training, a secondment and independent project management.

Keywords: sustainable development goals sdgs,electricity access,sub saharan africa,integrated energy planning,sustainable operations management