Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The sequencing microscope - a path to look at the molecules of biology (qScope)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The goal of biological research is to understand how life works. Although progress is fast, there seems to be an infinity of things we do not understand. When it comes to understanding tissue from the bottom up, our knowledge leaves much to desire. Feynman claimed that “It is very easy to answer many of these fundamental biological questions; you just look at the thing!” well the problem is that looking at the thing is the problem. Microscopy might never give us the possibility to directly see DNA- or RNA-sequence. For this, the community has evolved extraordinarily powerful sequencers. Today one man can routinely read millions of sequences on a weekly basis. And likely soon, we will read billions of sequences daily in small labs. But this, in itself, will not allow us to just look at the thing. We argue in this proposal, that by using the sequencer itself as a microscope, we will get that much closer to actually see what is going on in biological systems. Researchers have started in this direction by coupling microscopy- and sequencing-data from the same sample, but that is a temporary solution. Here, we propose a technology for inferring images using sequencing data alone, bypassing the need for advanced microscopy and leveraging the potential of the exponential growth of sequencing technology. We use DNA seeds and perform a reaction in-situ that allow these seeds to copy themselves locally. This is analogous to phylogenetic reconstruction, but instead of inferring ancestry, we infer relations of amplicons to spatial locations in tissue. By using a unique approach, we derive spatial information connected to RNA transcript information directly in-situ, allowing for a non-targeted spatial transcriptomics technique that is as simple as running a PCR. When successful, this approach will then enable us, and others, to learn the inner secrets of biological system at a significantly faster rate.

Keywords: spatial transcriptomics,dna molecular tools,dna nanotechnology,sequencing
Accelerating algae product developments in Baltic and North Sea (AlgaePro BANOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Germany,Norway,Estonia,Belgium,Latvia,Finland,Netherlands,Ireland,Denmark,Portugal,Sweden
Call: Lighthouse in the Baltic and the North Sea basins – bringing sustainable algae-based products and solutions to the market (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 12027291.25
EU funding (EUR): 10939104.65
Participants: 27
Project status: SIGNED

The AlgaeProBANOS project addresses a challenge in the Baltic and North Sea (BANOS) area: how to harmonise economic development with social and environmental goals in line with the Mission Ocean... There is a rising demand for green healthy natural consumer and biobased products, and algae can become the biomass resource of the future, without using fresh water, arable land, or added fertilisers and or pesticides. Both the Baltic and North sea engulf the necessary conditions to scale up production and produce both commodity and sophisticated algae-based products. AlgaeProBanos (APB) brings together 26 experts and industry partners from the BANOS area and beyond, to accelerate product development and market access of sustainable algae solutions. Concretely, APB will support six business pilots, SMEs and startups, to bring eight algae products to the market (TRL7-9) namely in food, feed, nutraceuticals, textiles, cosmetics and plant biostimulants applications. Value chains are based on microalgae and seaweeds, sourced in the Baltic or North Sea or from recycled resources. Innovation takes place in iterative loops with assessments to secure maximum robustness, efficiency, and sustainablesustainability. Furthermore value chains are built with end-users' needs put in the centre, through engaging users in co-creation activities, to ensure maximum uptake. Digital tools are developed to support all actors from biomass producers to consumers. In the end, GoToMarket strategies are tailored to the pilots, providing a trajectory to reach the market. In a meta level, the Algae Accelerator develops new and aggregates existing knowledge, and develops a portfolio of solutions, guidelines and a collaboration and training platform, to benefit the entire algae industry and nourish it into a thriving industry by 2050. The legacy of APB will be deposited to the Ocean Mission BANOS and the EU4Algae.

Keywords: products lighthouse marine market smes
Making contracts more human with state-of-the-art natural language processing techniques in Spanish (Bounsel AI)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Bounsel S.L. is a young innovative deep-tech company that focuses its activity on the use of Information Technology (IT) with the aim of offering, in the form of a service (SaaS), a software platform for the intelligent and comprehensive management of contracts powered by a Big Data infrastructure and driven by advanced Artificial Intelligence techniques (AI). For this purpose, the company's technological base is based on the application of Machine Learning and Deep Learning models, based on cutting-edge Natural Language Processing (NLP) techniques, applied to the legal field and unstructured content in Spanish and Portuguese. The company already has the platform on the market, and its activity for the coming years will focus, following the product roadmap, on its R&D strategy and the technical-functional improvements obtained from user feedback, on the development of new functionalities based on software and AI for the intelligent management of contracts making them more human-like so that a regular middle person can easily understand its content (Bounsel AI). The business model proposed by Bounsel is a transactional B2B SaaS that has different annual subscription pricing plans, and with an international projection focused on South America. Bounsel has currently a team of 8 people and is located in the Polytechnic City of Innovation of the UPV and maintains close collaboration with the Technological Institute of Informatics (ITI). The great relationship capacity of the founding team and its position in the legal tech market are exceptional. The wide recognition in the ecosystem is also remarkable. Among others, Bounsel counts on the support of the Women's Institute, the Youth Institute, IVACE, CDTI, Google for Startups, and the Polytechnic University of Valencia.

Keywords: ai nlp deep tech contract management legal tech
Building universal quantum computers with self-correcting cat-qubit technology (CatQubit)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-01-01
End date: 2025-12-31
Duration (months): 48.0
Total project cost (EUR): 9902431.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Quantum computers could completely revolutionise the world. A successful quantum computer could perform simulations that would take billions of years on the most powerful supercomputer in a matter of minutes. But first, there is a critical challenge to overcome. Current quantum computers are error-prone and incapable of executing complex algorithms reliably. Eliminating these quantum errors is the main challenge in quantum computing. We have invented a new type of self-correcting quantum hardware—the Schrödinger cat quantum bits (qubits). Using self-correction, we will be able to build the world's first fault-tolerant commercial quantum computers a decade earlier than our competitors. Quantum computing is a technology of the highest strategic importance. Today, American tech giants are ahead, but who will lead the quantum revolution is not decided yet. With self-correcting cat qubits, we can take the lead and ensure the next generation of information technologies are European.

Keywords: error correction,quantum errors,qubits,logical qubits,quantum computing
Fostering research careers in LIGHT sciences (FLIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Germany,United Kingdom
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 3024000.0
EU funding (EUR): 3024000.0
Participants: 16
Project status: SIGNED

FLIGHT is a 60-month MCSA COFUND doctoral program that aims at recruiting outstanding early stage researchers (ESRs) to carry out ambitious PhD-projects at ICFO in one of 3 tracks: Standrard, Industrial or Clinical. It will offer 30 highly competitive fellowships of 36 months duration, through 3 calls, to outstanding international candidates, and equip them unique capabilities to become future leaders in academic, industrial and clinical research. FLIGHT aims to fostering career mobility of researchers beyond the academic sector. The program includes an extensive training program of multidisciplinary scientific workshops and training events where all Fellows are exposed to the interdisciplinary mix between academic research and industrial/clinical work. ESRs in the Industrial and Clinical tracks will undertake research projects in collaboration with one of 14 Industrial and Clinical partners, from innovative start-ups to multinational companies and leading local hospitals, who will co-finance the ESRs' research projects, and provide co-supervision, extended secondments, research and training resources. FLIGHT will equip recruited Fellows with unique capabilities to launch a research career at the intersection of photonic sciences with a wide range of industrial and clinical applications, and enhance the European talent base in a field – photonic sciences – identified as vital to the ongoing competitiveness of the European Research Area.

Keywords: photonic sciences,industry,clinical sciences,intersectoral,interdisciplinary
The malaria zoo: dissecting cerebral malaria in three in vitro primate blood-brain barrier models (MAL-ZOO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 180096.96
EU funding (EUR): 180096.96
Participants: 1
Project status: CLOSED

Plasmodium falciparum cerebral malaria (CM) is the most severe complication during malaria infections. CM is associated with patient coma and blood-brain barrier (BBB) disruption resulting in brain swelling and patient death. In the zoonotic malaria parasite P. knowlesi, CM is described in rhesus macaques but occurs neither in human infections nor in the natural long-tail macaque reservoir. Infected red blood cell cytoadhesion to endothelial cells and the release of parasite toxins have been described as pathogenic mechanisms of falciparum CM. Both factors are present in P. knowlesi in all three primate hosts, albeit at different levels and result in different clinical outcomes. Therefore, I hypothesize that the pathogenic mechanisms of CM in primates are host and parasite-specific. As in vivo studies are limited to post mortem samples, I aim to develop in MAL-ZOO novel microvascular 3D in vitro models of the human, rhesus macaque and long tail macaque BBB. I will adapt existing differentiation protocols for human induced pluripotent stem cells (iPSC) to generate macaque endothelial cells, astrocytes and pericytes, that will be introduced in a 3D microvascular model. Taking advantage of the microfluidic properties of the devices, I will characterize the dynamics of P. knowlesi cytoadhesion to the endothelium of the three hosts. Afterwards, I will measure the BBB pathogenicity of these two parasites by confocal microscopy, functional permeability assays and RNAseq transcriptional analysis and correlate it to the parasite cytoadhesion levels. The cross-species comparison will be used to highlight species-specific virulence factors during P. falciparum and P. knowlesi infections. This will improve our understanding of the mechanisms leading to P. falciparum CM in humans and the pathogenic potential of zoonotic P. knowlesi malaria.

Keywords: bioengineering,in vitro infection models,cerebral malaria,p falciparum,p knowlesi,zoonotic malaria
Stepping into the light: exploring mono-ADP-ribosylation through super resolution STED microscopy (mArSTED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

ADP-ribosylation (ADPr) is a key post-translational modification catalyzed by the ADP-ribosyltransferase (ART) superfamily, including poly-ADP-ribose polymerases (PARPs), which, despite their name, can transfer either a single (mono-ADPr) or multiple (poly-ADPr; PAR) units of ADP-ribose to their targets. This process occurs in response to various biological and pathological stimuli, regulating numerous cellular functions. For many years, research in the ADPr field focused primarily on poly-ADPr PARPs, often overlooking the physiological importance and therapeutic potential of mono-PARPs. Recently, the development of new reagents, including versatile antibodies to detect mono-ADPr, provided essential tools to finally explore this elusive modification. Emerging evidence, partly obtained by using these antibodies, suggests that mono-ADPr responses could be promising therapeutic targets for immune-related diseases, pushing mono-ADPr into the spotlight. However, this growing pharmaceutical interest contrasts with our limited understanding of the molecular mechanisms and biological functions of mono-ADPr and the catalyzing enzymes. In this MSCA project, I aim to shed light on the functions of the underexplored mono-ADP-ribosylation by pioneering the development of super-resolution microscopy methods to visualize mono-ADPr localization across different cellular structures. Through this cutting-edge approach, my research will provide unprecedented insights into the spatial dynamics of mono-ADPr, potentially uncovering novel aspects of its functional roles in cells and providing powerful new methods for the ADP-ribosylation field. Additionally, I will investigate the crosstalk between two PARPs that, according to preliminary data from the host lab, may collaboratively mediate ADPr at the nuclear pore complex, providing insights into the molecular mechanisms underlying the findings from our microscopy studies.

Keywords: parps adp ribosylation
Avatar agency. Moral responsibility at the intersection of individual, collective, and artificial social entities in emergent avatar communities. (avataResponsibility)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Romania
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1494688.0
EU funding (EUR): 1494688.0
Participants: 1
Project status: SIGNED

This project investigates how avatar agency impacts practices of ascribing moral responsibility in emergent avatar communities (Metaverse, augmented Metaverse, and Human-Cybernetic Avatar societies). These communities challenge traditional frameworks of agency and moral responsibility. The unprecedented persistent and continuous use of multiple avatars by both humans and organisations, has the potential to permeate prior boundaries of the physical, the augmented and the virtual world. We propose a dynamic normative framework of ascribing moral responsibility that is grounded in a philosophical conceptualisation of avatar agency. This framework considers the way interactions between avatars, individuals, and organisations generate intertwined and mutual ascriptions of moral responsibility, potentially enhancing or, on the contrary, diminishing human agency and responsibility in emergent avatar communities. We construct our approach along five main objectives: 1) to clarify avatar agency and related responsibility pertaining to individual, organisational, and artificial members of emergent avatar communities; 2) to delineate the way avatar agency enhances or restrains individual agency and responsibility; 3) to correlate the way interactions between social entities in avatar communities generate mutually enhancing (or perhaps decreasing) ascriptions of moral responsibility to all participants; 4) to evaluate the extent in which the ethical characteristics of the community environment can generate normative attributions of responsibility; 5) to project normative evaluations of blaming and praising practices in avatar communities. The successful delivery of this ethical framework is an original contribution to the problem of moral responsibility and bears direct implications for future regulation, impacting societal moral practices of accountability and blaming.

Keywords: agency,moral responsibility,avatar,organizations,collective responsibility,human enhancement,normative ethics
Fluorides for 2D Next-Generation Nanoelectronics (F2GO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2498609.0
EU funding (EUR): 2498609.0
Participants: 1
Project status: SIGNED

The IRDS roadmap considers two-dimensional (2D) materials a promising option for scaling electronic devices down to atomic dimensions. While there has been a lot of progress regarding 2D semiconductors, all electronic devices require suitable insulators as well. Although a major show-stopper, insulators have received far less attention and their is no clear roadmap as to which insulators can be used for ultimately scaled nanoelectronics. My group was recently first to demonstrate back-gated 2D FETs using ultrathin calcium fluoride (CaF2) as an insulator. Based on these promising results, I firmly believe that fluorides, which are ionic crystals with often very wide bandgaps, can efficiently address the major challenges: (i) Although relatively exotic materials, their growth is considerably better established than that of any 2D material. (ii) CaF2 can be epitaxially grown layer-by-layer on silicon substrates and likely also on 2D semiconductors. As their F-terminated inert surface supports van der Waals epitaxy of 2D materials, they could be the missing link between 3D substrates and 2D semiconductors. (iii) The low-defectivity of the inert CaF2 surface will significantly improve device performance and stability. Thereby, fluorides will allow novel 2D devices to make the leap from promising concepts to highly performant and stable real devices. F2GO will establish fluorides as a key enabler for 2D nanoelectronics by successfully demonstrating device architectures which were previously impossible to fabricate with sufficient performance due to inadequate insulators. I will do so by investigating selected fluoride-based devices for key technologies: (i) steep slope devices for CMOS logic (Cold Source FETs) at the ultimate scaling limit to allow sub-100 mV operation and (ii) ultra-scaled non-volatile memory devices (Flash and TRAM). Thereby, F2GO will pave the way for fluoride-based nanoelectronics at the ultimate scaling limit as required for the generations 2030+.

Keywords: 2d materials,insulators,more moore,steep slope devices,non volatile memories