Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Noble-Gas Compounds meet X-ray Charge Density and High-Pressure Research (NgCHEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 85699.68
EU funding (EUR): 85699.68
Participants: 2
Project status: CLOSED

This project aims to study noble-gas compounds by X-ray charge-density analysis and explore the structural behavior of selected noble-gas species under high-pressure in GPa range. Experimental electron-density distribution of reactive fluorides is rarely studied and no experimental charge-density analysis on noble-gas compounds has been reported to this date. Moreover, there is a genuine interest in noble-gas chemistry under extreme conditions of high pressure. However, the vast majority of studies are computational predictions and experiment significantly lags behind the theory. The project results would constitute the first X-ray charge density analysis on noble-gas compounds. This would provide new insights into the chemical bonding of noble-gas compounds and nature of their intermolecular interactions. Moreover, diamond anvil cell experiments would significantly advance our understanding of the hitherto unknown high-pressure chemical and structural behavior of noble-gas compounds. An ambitious, but challenging, experimental charge-density analysis of noble-gas compound under high pressure in diamond anvil cell will also be undertaken. Special experimental methods and techniques will be employed for the synthesis and structural characterization of reactive and air-sensitive noble-gas compounds. The two-way transfer of knowledge and skills, therefore represents an important aspect of this project.

Keywords: noble gas compounds,charge density analysis,high pressure research,diamond anvil cell,fluorine,fluorides,crystal structure
Transforming brain surgery by advancing functional-guided neuronavigational imaging (HyperProbe)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Germany,France,Austria,United Kingdom
Call: Tools to measure and stimulate activity in Brain Tissue (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 3548325.0
EU funding (EUR): 3360825.0
Participants: 9
Project status: SIGNED

In recent years, through the advancement of imaging technologies (such as MRI, PET, CT, among others) clinical localisation of lesions of the central nervous system (CNS) pre-surgery has made possible for neurosurgeons to plan and navigate away from functional brain locations when removing tumours. However, neuronavigation in the surgical management of brain tumours remains a significant challenge, due to the inability to maintain accurate spatial information of lesioned and non-lesioned locations intraoperatively. To answer this challenge, we have put together a team of engineers, physicists, data scientists and neurosurgeons to develop an innovative, all-optical intraoperative imaging system based on (i) hyperspectral imaging (HSI) for rapid, multi wavelength spectral acquisition, and (ii) artificial intelligence (AI) for image reconstruction and molecular fingerprint recognition. Our intraoperative HSI system (HyperProbe) will (1) map, monitor and quantify biomolecules of interest; (2) be handheld and user-friendly; (3) apply AI-based methods for the reconstruction of spectral images, the analysis of spatio-spectral data and the development and quantification of novel biomarkers. We will validate the developed capacity in phantoms, in vivo against gold standard modalities in neuronavigational imaging, and finally provide proof-of principle during brain tumour surgery. HyperProbe aims at providing functional and structural information on biomarkers of interest that is currently missing during neuro-oncological interventions.

Keywords: neuronavigation,neurosurgery,hyperspectral imaging,functional imaging
Biological magnets as a unifying link to multidisciplinary research excellence (BioMagnetLink)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Latvia
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2629500.0
EU funding (EUR): 2629500.0
Participants: 1
Project status: SIGNED

Latvia, one of the widening countries, has defined research excellence as an important aim for its higher education and research system. In the BioMagnetLink project, we will focus on biological magnets as a unifying link to multidisciplinary research excellence building upon the expertise of the ERA Chair. The ERA Chair has indeed an already proven track-record of high-level publications, an ability to attract, train and lead talents, to foster the mobility of researchers and the interdisciplinarity of research, and finally to coordinate international projects in the most ambitious research level. Forming the ERA Chair team at the University of Latvia to tackle a groundbreaking research related to microswimmer and magnetotactic bacteria to progress towards future personnalized medicine approaches. In addition, building on its experience, the ERA Chair will formulate precise and detailed recommendations on talent attraction, project preparation and execution, result dissemination, doctoral education and others, adapted to the institutional and national research environment, making them easy to implement. The support and interest from the university senior management will allow to materialize changes for the whole university. This will be of a great value due to multiple reforms currently taking place for the higher education level at the University of Latvia itself, but also more generally in Latvia. To maximize the impact on the institutional environment, the ERA Chair will form a training group for local principal investigators, to help developing their leadership and writing skills. The positive effects on the largest research university in Latvia at the research, the training, and the structural level as shown by leading by example will promote systemic changes for the benefit of the whole country, thereby progressing towards closing the still existing gap towards other European countries.

Keywords: microswimmers magnetotactic bacteria interdisciplinarity lead by example research excellence
Boosting Sustainable Innovation in Developing New Antibiotic Adjuvants to Control Biofilm Resistance (InnovAntiBiofilm)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Portugal,France,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1526103.56
EU funding (EUR): 1483246.42
Participants: 4
Project status: SIGNED

InnovAntiBiofilm will revolve around the subject matter of sustainable development of new adjuvant agents to boost the action of antibiotics against biofilm infections. This will be achieved through the sustainable biosynthesis of plant molecules and the rational development of derivatives. These scientific activities, together with capacity building and networking activities, talent development of young researchers, mentoring, inclusiveness, and strengthening research management and administration skills, will be at the crux of the project concept. This will be achieved by Twinning UPORTO with truly outstanding EU institutions with recognised expertise in the areas of medicinal and combinatorial chemistry (CEA), metabolic and bioprocess engineering (Fraunhofer-IME), and R&I management, access to funding and links with industry (KPMG). These internationally-leading partners will provide decisive expertise to capacitate UPORTO on the heterologous biosynthesis of phytochemicals and development of innovative phytochemical derivatives with improved antibiotic adjuvant action for biofilm control, as well as to strengthen UPORTO’s R&D competitiveness and administrative skills. The objectives of InnovAntiBiofilm are in line with the specific challenge and scope of the topic HORIZON-WIDERA-2023-ACCESS-02-01 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. InnovAntiBiofilm will allow the development of a consolidated strategic research approach and a set of guidelines for exploitation and commercialisation of the results that will have a strong regional, national and European impact. The project integrates synergies in complementary fields of research that include biotechnology, microbiology, synthetic chemistry and pharmacognosy, aiming to obtain scientific breakthroughs that can improve global health and economy.

Keywords: research capacity,young talents,academia industry cooperation,antibiotic adjuvants,antimicrobial resistance,biofilms,bioprocess engineering,combinatorial chemistry,medicinal chemistry
Underground Large Scale Seasonal Energy Storage for Decarbonized and Reliable Heat (USES4HEAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Sweden,Italy,Spain,Norway,Belgium,Croatia,Bulgaria,Greece
Call: Demonstration of innovative, large-scale, seasonal heat and/or cooling storage technologies for decarbonisation and security of supply (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 12396882.5
EU funding (EUR): 9647826.0
Participants: 27
Project status: SIGNED

Today, the heating sector is not on track toward achieving the IEA Net-Zero targets: it represents more than a third of the energy demand and it mainly relies on fossil fuels. District heating is recognized as a major solution allowing decarbonization of the heating sector. The integration of large-scale seasonal energy storage, compensating for the mismatch between supply and demand whilst ensuring the service, is key for a wide spread of district heating. USES4HEAT aims to demonstrate innovative, large-scale, seasonal thermal energy storage solutions enabling a future decarbonized and reliable heating supply. USES4HEAT demonstrates, at TRL8 and for a one-year test campaign, two innovative, cost-effective, large-scale, seasonal underground TES units to maximize the availability and resilience of heating supply while reducing energy losses and environmental impact. USES4HEAT seeks to demonstrate the storages as fully integrated units in commercial large-scale district heating networks and industrial waste heat recovery and fulfilling industrial thermal demand. In doing so, USES4HEAT also demonstrates six innovative key enabling components/technologies and their integration with seasonal storages: advanced drilling equipment and remotely controlled machines halving drilling times, innovative layered high-temperature borehole pipes, efficient groundwater heat pumps integrated with aquifer storages, hybrid solar panels and thermal solar collector, and accurate AI-based energy management tools. USES4HEAT will systematically demonstrate the effectiveness and techno-economic-social viability of innovative, large-scale, seasonal energy storages ensuring limited CAPEX, reduced environmental impact and energy losses, efficient integration in district heating and accumulation of various sources of heat, and granting reliable and decarbonized heating supply.

Keywords: underground thermal energy storage district heating industrial waste heat renewable integration sector coupling intelligent energy management demonstration
TERRITORIAL AND REGIONAL DEMONSTRATIONS OF SYSTEMIC SOLUTIONS OF KEY VALUE CHAINS AND THEIR REPLICATION TO DEPLOY CIRCULAR ECONOMY (TREASoURcE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Finland,Norway,Denmark,Estonia,Germany
Call: Circular Cities and Regions Initiative (CCRI)’s circular systemic solutions (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 10476617.78
EU funding (EUR): 9995239.5
Participants: 19
Project status: SIGNED

TREASoURcE will innovatively circulate currently incinerated, exported, landfilled or dumped plastic and biobased side and waste streams by deploying systemic circular economy (CE) solutions. The systemic CE solutions will integrate the two main elements of TREASoURcE: stakeholder engagement demonstrations (SE-DEMOs) and key value chain demonstrations (KVC-DEMOs). The DEMOs support chosen territory clusters in introducing CE practices to their citizens and businesses to help 1) decouple from use of fossil virgin resources and excess raw material consumption, 2) increase resilience (self-sufficiency, value chain security, environment and nature), 3) decrease GHG emissions and contribute to achieve climate neutral economies. Climate change, environmental degradation and loss of biodiversity are major global threats that require urgent collaborative actions across industry, sectors, cities and regions, communities and citizens. Half of total GHG emissions and more than 90 % of biodiversity loss come from resource extraction and processing. Global consumption of materials, especially biomass, fossil fuels, metals and minerals are expected to double by 2060 and annual waste generation is estimated to increase by 70 % by 2050. TREASoURcE focuses on demonstrating the CE solutions in cities and regions located in the Nordics (Finland, Sweden, Norway and Denmark), and they will be replicated in the Baltics (Estonia, Latvia, Lithuania), Poland and Germany (of the Baltic Sea Region). The combination of the cities and regions will enable large reach and bigger impact and boost the replicability and scalability potential of the CE solutions. A common issue of the regions’ material circulation is low and decentralised material volumes and resulting challenges in feasibility, and bottlenecks have been high risk investments due challenges in securing sufficient feedstock (quality and quantity). However, regional strengths lie in ambitious climate and environmental targets.

Keywords: plastics,biogasification,batteries,recycling,reuse,job creation,business opportunities,resource sufficiency,social innovation,rural development,urban development,value chains,co creation
Scalable Parallel and distributed Astrophysical Codes for Exascale (SPACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Italy,Belgium,Czechia,Germany,France,Norway,Greece,Spain
Call: Centres of Excellence preparing applications in the Exascale era (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7994812.5
EU funding (EUR): 3997406.0
Participants: 15
Project status: SIGNED

In Astrophysics and Cosmology (A&C) today, High Performance Computing (HPC)-based numerical simulations are outstanding instruments for scientific discovery. They represent essential tools and theoretical laboratories able to investigate, interpret and understand the physical processes behind the observed sky. For these laboratories, the efficient and effective exploitation of exascale computing capabilities is essential. Exascale systems, however, are expected to have a heterogeneous unprecedented architectural complexity, with a significant impact on simulation codes. Consequently, the proposed SPACE CoE aims to extensively re-engineer the target codes to engage with new computational solutions and adopt innovative programming paradigms, software solutions, and libraries. SPACE aims to foster the reuse and sharing of algorithms and software components in the A&C application domain. The proposed SPACE CoE will address this action through co-design activities that bring together scientists, code developers, HPC experts, HW manufacturers and SW developers, advancing lighthouse exascale A&C applications, codes, services and know-how promoting the use of upcoming exascale and post-exascale computing capabilities. In addition, SPACE will address the high-performance data analysis of the data torrent produced by exascale A&C simulation applications, also with machine-learning and visualization tools. The deployment of applications running on different platforms will be facilitated by federating capabilities focusing on code repositories and data sharing, and integrating European astrophysical communities around exascale computing by adopting software and data standards and interoperability protocols.

Keywords: astrophysics cosmology exascale gpu computing
Innovative Approaches for an Integrated Use of Algae in Sustainable Aquaculture Practices and High-Value Food applications (INNOAQUA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Norway,Spain,Portugal,France,Germany,Slovakia,Belgium
Call: Innovative food from marine and freshwater ecosystems (HORIZON-CL6-2022-FARM2FORK-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 7179579.72
EU funding (EUR): 5995271.4
Participants: 17
Project status: SIGNED

The Farm to Fork Strategy of the European Green Deal has acknowledged the potential of algae to become an important source of alternative low-carbon footprint protein and contribute to improve the sustainability and competitiveness of the aquaculture sector. Nonetheless, the European algae industry is still at an early phase lagging behind the overall increase seen at a global level, mostly driven by Asia. Within this context, INNOAQUA aims to pave the path towards the upcoming sustainable and diversified EU in-land aquaculture industry by leaning on the demonstration and mainstreaming of innovative algae-based foods and solutions, and ecology, circularity and digitalization concepts. To this end, the project will address main barriers hindering the growth of the sector, starting with the demonstration at a pre-commercial level (TRL6-7) of the operational, technical, and socio-economic robustness of digitally enhanced integrated fish and algae RAS-IMTA cultivation systems, continued by the piloting of optimised processing techniques following biorefinery principles and the formulation of high added value seafood products. All this, accompanied by a dedicated waste minimisation and valorisation strategy to help optimizing and increasing its economic and sustainability performance. Moreover, INNOAQUA will also work on understanding how consumer perceptions and social norms influence the consumption of innovative seafood products by co-creating the products together with end-users and simulating their uptake in digital models of communities to identify effective market deployment and penetration strategies. Lastly, INNOAQUA will be enhanced by the adoption of a multi-level outreaching strategy which will the development of robust dissemination, communication and exploitation plans, materials for skills development and activities to foster international cooperation, aimed at fostering knowledge transfer and ultimately helping maximize the project’s scope and impact.

Keywords: algae,ras,imta,seafood,packaging,fish waste processing
Microbial extracellular polymeric substances based-technology for selenium removal from drinking and wastewater using CSTR and UASB reactors (BIOTAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-15
End date: 2027-05-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: TERMINATED

Selenium (Se) is a naturally occurring trace element in the earth's crust. Microorganisms and their metabolites, such as extracellular polymeric substances (EPS) play a major role in the redox transformation of metalloids in the environment. However, how EPS affects Se oxyanions redox cycling in drinking water and wastewater, what the underlying mechanisms, especially electron transfer mechanisms between EPS and Se, and which components of EPS are involved in Se redox transformation are unclear. Especially concerning electron transfer mechanisms between EPS-Se oxyanions to form BioSeNPs and which redox-active components of EPS are involved in the redox cycling of Se oxyanions. How EPS-mediated reduction of Se affects the isotopic fractions of Se during the reduction process. To what extent do these pure cultures strain-derived EPS-Se oxyanions reduction mechanisms apply to the Continuous Stirred Tank Reactor (CSTR) and an Up-flow anaerobic sludge blanket (UASB) reactor system for water and wastewater treatment, respectively. In this research, we plan to set up in situ and in vitro microcosms combined with electrochemical and spectroscopic techniques to examine 1) the key agents and structural components of EPS involved in the reduction of Se(IV/VI), 2) the electron transfer mechanisms between EPS and Se oxyanions for the reduction of Se(IV/VI); 3) the significance of the Se reduction to the environmental fate and recovery of BioSeNPs in CSTR and UASB reactor. The roles of EPS-mediated reduction processes on the isotopic fractions of Se. The results from this project will be vital to clarifying the role of microbial EPS and their components in the BioSeNPs cycle and developing biotechnologies to remediate and recover environmental Se.

Keywords: microbial biotechnology for remediation of environmental selenium