Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SPACE SAR system with integrated photonic BEAMforming (SPACEBEAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Germany,Italy,Belgium,Netherlands
Call: Earth observation technologies (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 3098751.25
EU funding (EUR): 3003751.25
Participants: 6
Project status: SIGNED

SPACEBEAM aims at designing, realizing and testing an innovative radar receiver that will enable the concept of reconfigurable multi-beam Scan-on-Receive Synthetic Aperture Radar for Earth observation applications. In order to comply with the requirements of future swarms and constellations of low-Earth orbit satellites and cubesats in terms of performance, size, weight, power consumption and cost, the envisioned receiver will be based on an optical beamforming network realized as a photonic integrated circuit (PIC). The PIC will implement a precise, continuous beamforming of wideband signals (>600MHz) from an array of 12 antenna elements into 3 beams of 4 antennas each, with the capability to flexibly change the set of antennas per beam, as well as the number of output beams (from 3 beams of 4 antennas each, to 2 of 6, to 1 of 12). At the same time, the PIC will also realize a frequency-agnostic photonic down-conversion of signals in the range from 5 to 40 GHz, down to 1.5 GHz, so that the output signals can be directly digitized. These innovative features make the SPACEBEAM PIC a powerful device for future Earth observation applications. The PIC will be implemented using two materials platforms, to achieve a compact “hybrid” chip-assembly including several active and passive functions (lasers, detectors, modulators, filters, switches, delays, phase shifters). The PIC will be controlled using a novel actuation technique based on low-power consuming piezo elements. In order to push forward the maturity of the SPACEBEAM technology (target TRL 6), the project will also develop and test a Space-compliant package for the PIC. The packaged PIC will be included in a specifically designed Engineering Qualified Model of the multi-beam SCORE-SAR sensor, to properly test the performance of the entire system. The photonics-based SCORE SAR system will therefore show more functionalities, better performance, and lower size, weight, and power consumption than the current systems.

Keywords: sar system,scan on receive,optical beamforming,integrated photonics
MITHAML – Exploring the role of Metabolic IntraTumoral Heterogeneity in drug resistance of Acute Myeloid Leukemia in vivo (MITHAML)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: TERMINATED

Drug resistance is a major barrier in acute myeloid leukemia (AML) for which prognosis remains unfavorable. We and others have shown the importance of metabolism in the response to therapies in AML, leading to the development of several drugs targeting mitochondrial functions such as BCL2 inhibitor Venetoclax or Electron Transfer Chain Complex I inhibitor IACS-010759. Tumors are composed of genetically and phenotypically heterogeneous cell populations, not all cells being equal in their ability to respond to treatment. Tremendous advances in single-cell technologies like mass cytometry (CyTOF) have demonstrated a fantastic potential to decipher this phenotypic and signaling heterogeneity. However, metabolic features are mostly measured in bulk, impeding the assessment of the metabolic cellular heterogeneity. We propose to investigate the role of metabolic intratumoral heterogeneity in AML at diagnosis and after new drugs in vivo through 2 aims. First we will determine the relationship between metabolic, signaling and developmental states in healthy and leukemic myeloid bone marrow cells and its link with chemoresistance (Aim 1). Then we will focus on the impact of Venetoclax and IACS on MITH in vivo using patient-derived xenograft mice models to identify specific features related to resistance to these drugs that we will finally therapeutically target with new combinations in vivo (Aim 2). The skills of the experienced researcher (ER) on metabolism and omic technologies and the complementary expertise of the 2 laboratories are key for the success of MITHAML. Indeed, the ER will be trained for 2 years in Dr Davis’s lab (Stanford University, USA), highly recognized in the study of intratumoral heterogeneity especially with CyTOF. She will then bring back these skills in Dr Sarry’s lab (Inserm, France), expert in in vivo AML resistance. This fellowship will be key to help the ER develop the scientific, technological and management skills required for her independence.

Keywords: mass cytometry,single cell,metabolic heterogeneity,mitochondria
Eco-aware Persuasive Networked Data Devices for User Engagement in Energy Efficiency (GREENSOUL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Austria,Spain,Spain,Greece,United Kingdom,United Kingdom
Call: New ICT-based solutions for energy efficiency (H2020-EE-2015-2-RIA, 2015)
Start date: 2016-04-01
End date: 2019-10-31
Duration (months): 43.0
Total project cost (EUR): 1881500.0
EU funding (EUR): 1881500.0
Participants: 13
Project status: CLOSED

GreenSoul pursues higher energy efficiency in public buildings by altering the way people use energy consuming shared devices (lights, printers) and personal devices (personal pluggable appliances). For that, it applies a twofold strategy: 1)persuades users to increase their energy-awareness and change their e-consumption habits and 2)embeds intelligence in the devices to let them autonomously decide about their operation mode for energy efficiency purposes. For the first part, it will use a variety of techniques, from persuasive social applications to physical interaction mechanisms linked to the devices. For the second part, it will learn from the usage habits, acting only when an energy wasteful behaviour is detected or the users do not heed the devices’ suggestions. The aim is to add a green-soul to devices in a pluggable manner to avoid costly replacement of equipment and the corresponding disposal of old-fashioned devices to the landfill. GreenSoul’s exploitation potential is addressed towards buildings of public use. There, the persuasion of users is particularly challenging since they hardly perceive the benefits of having eco-friendly behaviour, i.e. they do not pay the electricity bill. GreenSoul will design and develop an integrated ICT platform to: a) improve users awareness of their energy consumption habits; b)study the ecological behaviour of the people in shared environments; c)analyse the effectiveness of different persuasion techniques; d)assist users through a decision-support engine’s recommendations; and e)provide socio-economic evidence about the viability of the changes proposed. GreenSoul aims to prove that combined behavioural and ICT interventions over public buildings result in energy savings which surpass 20%. It will be deployed in five building pilots at different climatic areas and associated to different usage and facilities, ensuring the cross-country and cross-building analysis of the impact of GreenSoul.

Keywords: socioeconomic impact,behavioural models,environmental and consumption data
Supramolecular Recognition in Dynamic Covalent Networks at Equilibrium and Beyond (SUPRANET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Over the past two decades, a branch of organic chemistry has emerged that breaks with the paradigm of synthesizing pure compounds and focusses instead on complex (macro)molecular networks akin to those found in nature. In this proposed project, we aim to address unmet challenges in supramolecular chemistry and systems chemistry by developing original dynamic reaction networks whose building blocks are capable of supramolecular (self-)recognition. The first two objectives of SUPRANET focus on the use of dynamic covalent orthoester networks for the discovery of anion, cation and ion pair receptors, whose unique properties may pave the way towards the utilization of inorganic ions as drugs. For instance, we will develop self-assembled ion pair cages for the electro-neutral transport of medicinally relevant anions across phospholipid membranes. Our network approach will also allow us to “imprison” ionic guests for the first time in self-assembled receptors that could be used for the transport and controlled release of ions, even against osmotic pressure. Objectives three and four of SUPRANET go beyond the equilibrium state and, as such, are relevant to the chemistry of life, in which key processes depend on dissipative steady states. The proposed reaction networks will feature biologically relevant ribose building blocks that are continuously assembled and disassembled by two different irreversible reactions, resulting in steady state mixtures of either RNA oligomers or ribose-derived vesicles. It is our hope that these studies will provide insights into open questions regarding the molecular origins of life, such as the non-enzymatic formation of RNA oligomers capable of self-recognition and the simultaneous emergence of compartmentalization and self-replication. SUPRANET thus seeks to break new ground in both equilibrium and far-from-equilibrium dynamic networks and is equally motivated by applied and fundamental challenges.

Keywords: systems chemistry,dynamic covalent chemistry,origins of life
An Atomic Quantum Simulator with long-range, multi-body interactions (CriLiN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Ultracold atomic gases have emerged as ideal quantum simulators, as they enable experimentalists to study the interplay between the properties of a quantum many-body system and the interactions between its constituents with unmatched accuracy. However, in spite of impressive progresses, an atomic quantum simulator of highly correlated fermionic matter, able to address both phenomena of exotic superfluidity and itinerant ferromagnetism, still awaits experimental demonstration. Such a system needs to be built from the ground-up by carefully harnessing the underlying few-body physics. In CriLiN I will develop and test a new kind of Atomic Quantum Simulator of unequal-mass spin-1/2 fermions with long-range, multi-body resonant interactions. In order to do so, I will exploit the still unexplored 6Li-53Cr Fermi-Fermi mixture which, thanks to its special mass ratio of M/m=8.8, exhibits unique few-body properties that strongly favour the many-body phases of our interest. Indeed, on the “molecular side” of an interspecies s-wave Feshbach resonance, the Cr-Li system supports a real (virtual) stable universal trimer (tetramer) state, while benefiting from quantum-interference induced suppression of three-body recombination processes. At the few-body level, this will allow for the first time to resonantly tune multi-body, long-range p-wave interactions. At the many-body level, this will allow both to investigate Stoner's model of itinerant ferromagnetism and to greatly enhance the possibility to attain elusive superfluid regimes or topologically non-trivial p-wave superfluids. In CriLiN I will: (i) realize a degenerate 6Li-53Cr Fermi-Fermi mixture and identify intra- and inter-species Feshbach resonances suitable for our simulator; (ii) unveil and characterize stable cluster states and exploit them to resonantly tune three- and four-body elastic interactions; (iii) demonstrate the suppression of inelastic pairing processes in repulsively interacting mixtures.

Keywords: ultracold,mass imbalance,p wave,few body,interactions,ferromagnetism,superfluidity
A Data Platform for the Cognitive Ports of the Future (DataPorts)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Spain,Israel,Germany,Greece,Greece,Greece,France
Call: Supporting the emergence of data markets and the data economy (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 6675951.75
EU funding (EUR): 5740586.63
Participants: 16
Project status: SIGNED

DataPorts will boost the transition of European seaports from connected and digital to smart and cognitive, by providing a secure environment for the aggregation and integration of data coming from the several data sources existing in the digital ports and owned by different stakeholders, so that the whole port community could get real value from this data in order to improve their processes, offer new services and devise new AI based and data driven business models. To this end, DataPorts will design, implement and operate an Industrial Data Platform (Cognitive Ports Data Platform) that: i) connects to the different digital infrastructures currently existing in digital seaports, enabling the interconnection of a wide variety of systems into a tightly integrated ecosystem, ii) sets the policies for a trusted and reliable data sharing and trading based on data owners rules and offering a clear value proposition, and iii) leverages on the data collected to provide advanced Data Analytic services based on which the different actors in the port value chain could develop novel AI and cognitive applications. DataPorts project involves the design and implementation of the platform, its deployment in two relevant European seaports connecting to their existing digital infrastructures and addressing specific local constraints, a global use case involving these two ports and other actors and targeting inter-port objectives, and all the actions to foster the adoption of the platform at European level. This project will imply that tools, platforms and systems running in the different seaports all across Europe will benefit from the DataPorts industrial data platform, in order to create an even more trusted, reliable and efficient way of conducting businesses in Europe and to reinforce the European Single Market.

Keywords: seaports,maritime,transport,logistics,shipping,data,platform,industrial,trust,security,protection,privacy,sharing,trading,exchanging,brokering,markets,spaces,innovation
Establishing Laboratory of Advanced Materials at the Comenius University (LAMatCU)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Slovakia
Call: ERA Chairs (H2020-WIDESPREAD-03-2017-ERAChairs, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 2496750.0
EU funding (EUR): 2496750.0
Participants: 1
Project status: SIGNED

The key objective of this proposal is to establish a new Laboratory for Advanced Materials (LAM) at Comenius University (CU) under the direction of the appointed ERA Chair holder. LAM is meant to be a world-class research interdisciplinary laboratory focused on advanced materials research, particularly for applications in the areas such as energy conversion and storage, electronics, and optoelectronics. Existence of LAM will: - strengthen the potential and the contribution of CU to this area of research in the wider ERA in tight connection to the central idea of the Work Programme - Spreading Excellence and Widening Participation - help counteracting the eminent brain drain Slovakia is experiencing by attracting brilliant young researchers from both Slovakia and abroad - consequently strengthen the position of CU as a leading research and educational institution in Slovakia as well as raise its significance in Europe The structure and management of LAM is designed to ensure its future self-sustainability and continuity of its research. Project funds will be utilized in establishing LAM and maintaining LAM's initial operation period, during which following actions will be taken to secure future financial sustainability: - top-quality research personnel will be recruited bringing in international scientific collaborations - external collaborations with the industry will be actively sought - opportunities to utilize research outputs as intellectual property and patents will be exploited - research grants connected to the area of research interests will be applied for - public outreach activities will be focused on stimulating interest and engagement among students Within this scheme, the project funding will serve as the initial kick-start of a new internationally acclaimed prime research facility (LAM), activating the whole field of materials research at CU, thus having a positive long-term effect on the status of research excellence in Slovakia as well.

Keywords: advance materials,synthetic,fabrication methods,energy conversion,computational screening of materials,material properties prediction,characterization techniques,proof of concept applications
Holography for Asymptotically Flat Spacetimes (HoloFlat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 270349.44
EU funding (EUR): 270349.44
Participants: 2
Project status: CLOSED

Even after more than 100 years Einstein’s theory of General Relativity still resists a complete understanding at the quantum level. Holographic dualities between theories of quantum gravity and quantum field theories such as the Anti-de Sitter/Conformal Field Theory correspondence have revolutionised the way we think about both subjects since its discovery. However, holographic applications to other – more realistic – setups such as asymptotically flat spacetimes still provide a fundamental challenge in theoretical physics. The aim of this project is to overcome this challenge by developing new holographic tools that involve the entire boundary of asymptotically flat spacetimes. The long-term goal of FlatHolo is to apply these tools to spacetimes such as e.g. the Schwarzschild or the Kerr-Newman black hole in order to gain a deeper understanding of these objects at a quantum level. The short-term goals of developing a concise framework for a putative dual quantum field theory and consequently relating boundary entanglement with bulk geometry are also of high interest for other scientific communities that are unravelling the intriguing relations between quantum information and geometry. This proposal combines my current expertise on non-AdS holography with extensive training by leading experts on various aspects of holography involving asymptotically flat spacetimes at Harvard University. The final stage of the project will be conducted at the University of Vienna whose complementary expertise on higher-spins, holography and gravitational physics provides the perfect environment to transfer my knowledge and skills gained during the outgoing phase. The outcomes of this project will be essential for a deeper understanding of holography in more realistic setups and will allow me to proceed with the next step in my career and reach professional maturity by qualifying for a permanent position as an independent researcher at a European research institution.

Keywords: holography,flat space,quantum gravity,entanglement entropy
Pan-European Response to the ImpactS of COVID-19 and future Pandemics and Epidemics (PERISCOPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Italy,Italy,Spain,Italy,Italy,Italy,Belgium,Belgium,Switzerland,Belgium,Sweden,Poland,Romania,Serbia,France,France,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Behavioural, social and economic impacts of the outbreak response (H2020-SC1-PHE-CORONAVIRUS-2020-2-RTD, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 9993475.0
EU funding (EUR): 9993475.0
Participants: 32
Project status: SIGNED

The impact of the COVID-19 pandemic has been deep and wide. In spite of unprecedented efforts to understand the COVID-19 disease and its causative virus SARS-CoV-2, months after the emergence of the first local case in Europe (San Matteo hospital, Pavia, 21st February 2020) significant knowledge gaps persist. While social and natural scientists managed to develop new research and shed light on the dynamics of the outbreak and the most effective possible containment measures, governments have been increasingly faced with the need to adopt urgent decisions. Against this background, PERISCOPE plans to contribute to a dramatically deeper understanding of the dynamics of the outbreak, by means of an intense multi-disciplinary research, both theoretical and experimental, and the consideration of different viewpoints: clinic and epidemiologic; humanistic and psychologic; socio-economic and political; statistical and technological. The overarching objectives of PERISCOPE are to map and analyse the unintended impacts of the COVID-19 outbreak; develop solutions and guidance for policymakers and health authorities on how to mitigate the impact of the outbreak; enhance Europe’s preparedness for future similar events; and reflect on the future multi-level governance in the health as well as other domains affected by the outbreak. In pursuing this objective, PERISCOPE sheds new light on the unintended and indirect consequences of the outbreak and the related government responses, with the intention to preserve evidence-based policymaking by collecting an unprecedented amount of data and information on the social, economic and behavioural consequences of the current pandemic. At the same time, PERISCOPE will produce new information on the conditions that led to the impact of the pandemic, the differences in “policy mix” adopted at the national level in EU and associated countries, and the behavioural impacts of both the outbreak and the policies adopted.

Keywords: statistical modeling,epidemiology