Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of nuclear architectural RNAs in the long-term maintenance of the neural epigenome (NEUTIME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1999970.0
EU funding (EUR): 1999970.0
Participants: 1
Project status: SIGNED

Neurons in the brain must function for a life-time with limited replacement; thus, they need to robustly maintain their identity and function. Understanding the mechanisms underlying the longevity and persistence of neurons will be key for preventing and treating age-related neurological diseases. By focusing on epigenetic mechanisms regulated by nuclear RNAs, the project aims at understanding the fundamental mechanisms underlying the long-term maintenance of neural identity and their biological roles in the development of age-related vulnerability. The successful completion of this proposal will uncover novel roles of RNAs in long-term epigenetic regulation, and key biological links between epigenetic dysregulation and age-related pathological development. We recently discovered that some nuclear RNAs in rodent brains do not turn over for two years. These RNAs are maintained in a neural cell type-specific manner and are mainly localized around heterochromatin. Through a targeted approach, satellite RNA was found to be one of the stable nuclear RNAs and is critical for the maintenance of heterochromatin. Based on this finding, the proposed project aims to test the specific hypothesis that neural cells possess several long-retained nuclear RNAs which interact with chromatin to stabilize cell type-specific epigenetic regulation, but that they deteriorate as a result of aging. To address this question, we will use an interdisciplinary approach. First, the molecular identity of long-retained nuclear RNAs will be probed globally using deep sequencing. In parallel, mechanisms responsible for maintaining RNAs will be investigated Second, the roles of the nuclear RNAs and associated complexes we identify in maintaining cell type-specific epigenetic regulation will be investigated using neurobiological, epigenomic and biochemical approaches. Efforts will be directed toward understanding the roles of nuclear RNAs in pathophysiological brain aging.

Keywords: brain aging,longevity,epigenetics
Resolving Ocean Macroscale Turbulence (ROTurb)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-16
End date: 2027-09-15
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

"Resolving Ocean Macroscale Turbulence" (ROTurb) is a proposal to fund a fellowship to be carried out by the Experienced Researcher (ER) Simone Silvestri at the host institution Polytechnic University of Turin, Italy (POLITO) in the Department of Environment, Land and Infrastructure Engineering (DIATI) under the supervision of main host Professor Jost von Hardenberg. The aim of the proposed work is twofold. From a scientific perspective, the goal is to investigate the role of macroscale turbulent processes in ocean models through a hierarchy of coupled ocean sea ice simulations that follow the ocean model intercomparison project OMIP2. Regarding technological innovation, the aim is to develop a submesoscale permitting model that runs at climate-relevant scales. Macroscale turbulence in the ocean, broadly subdivided into mesoscale and submesoscale features, is the primary driver of the lateral transport of heat, carbon, and nutrients. Furthermore, submesoscales, associated with surface fronts, have been suggested to play a pivotal role in determining the vertical transport of heat and carbon in the ocean and modulating air-sea fluxes. However, due to their small scale, these processes are typically not represented in global ocean models. The ER and colleagues have recently developed a model that, by leveraging Graphical Processing Units (GPUs), achieves computational performance up to 100 times higher than state-of-the-art models. This new model, called ClimaOcean, enables unprecedented high-resolution simulations, making it possible to explore kilometer-scale turbulent processes and their impact on climate-relevant metrics within a global ocean framework for the first time.

Keywords: physical oceanography,ocean turbulence,high resolution modeling
A Coherent Analysis Framework for Emergence in Biological Systems (CAFE-BIO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom,Germany,Spain,France,Italy,Luxembourg,Netherlands,Poland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 4541464.08
EU funding (EUR): 4541464.08
Participants: 18
Project status: SIGNED

This network will provide a rigorous training in solving complex problems in the context of emergence in biological systems, combining approaches from many scientific traditions. A major scientific challenge lies in understanding how dense many-body systems with complex interactions behave at the macroscopic scale under noisy non-equilibrium biological conditions. A coherent framework for performing such an analysis, grounded in the principles of statistical physics, demands an integration of multiple approaches that are currently applied in isolation and in a fragmented fashion. This network will build this coherence, by bringing together multiple partners with substantial complementary expertise, and through individual research projects that are each designed to combine this expertise in fundamentally new ways. Through this, we will gain new understanding of the novel physical interactions that biological systems create, establish quantitative relationships between microscopic interactions and macroscopic collective effects, and confront the complexity of real-world systems through data-driven modelling and experimental applications. This new understanding has a range of important applications, including cancer growth, cardiac health, biofilm formation and animal fertility. The research training will be complemented by professional training in advanced digital skills, such as software and data carpentry, as well as in entrepreneurship, communication and public engagement, much of which will be delivered through non-academic partnerships. All doctoral candidates will complete academic or non-academic secondments for a substantial period. These experiences will fill transferable skills gaps in traditional doctoral research training, and build doctoral candidates’ career prospects and the European skills base in the digital economy. Lasting elements of the programme include this novel training, and a series of public engagement activities that will be created.

Keywords: active matter physics biological living matter physics
AI-Driven EXplainable Advertising Optimizer (ADEXA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Türkiye
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: CLOSED

AI-Driven Explainable Advertising Optimizer ADEXA is a breakthrough autonomous advertising optimization system that empowers European SMEs with enterprise-level marketing intelligence through explainable, causal AI. Developed by WASK Bilgi Teknolojileri A.Ş., a digital transformation technology company serving over 7,000 subscribers internationally, including a substantial European base, the platform transforms advertising from reactive management into predictive, self-optimizing decision-making. Unlike black-box optimization tools, ADEXA deploys proprietary causal inference algorithms that identify genuine cause-effect relationships between creative elements, audience signals, and conversion outcomes. This enables autonomous optimization with complete transparency into every decision. The platform integrates three breakthrough capabilities: federated learning architecture ensuring GDPR compliance and data sovereignty, generative creative intelligence that adapts content based on real-time signals, and an explainable recommendation engine meeting EU AI Act transparency requirements. European SMEs waste approximately 35% of digital advertising budgets due to manual optimization and limited AI access. ADEXA addresses this inefficiency while democratizing advanced capabilities, reducing customer acquisition costs by up to 40% with full auditability essential for regulated industries. WASK's deep-tech research in advertising automation has established the company as a digital transformation partner for European SMEs across manufacturing, retail, professional services, and e-commerce sectors. The project advances ADEXA from TRL 6 to TRL 8, implementing privacy-preserving federated learning, multi-platform causal inference, and enterprise security architecture. ADEXA directly supports EU Digital Decade objectives by strengthening SME competitiveness and advancing trustworthy AI while reducing dependency on non-EU platforms.

Keywords: ai,deep tech,ml,adtech,sme,optimization,saas
Uncovering the Regulators of Cellular Plasticity by Direct Reprogramming (RePLASTIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

Cellular reprogramming has revolutionized stem cell biology by allowing the generation of stem cells, progenitors, or somatic cell identities with small combinations of transcription factors (TFs). Currently, the limited understanding of how these different degrees of plasticity are established and maintained keeps on hold the application of reprogrammed cells in the clinic. With the RePLASTIC project, I propose to uncover novel regulators that define degrees of plasticity and control cell identity, with an interdisciplinary approach merging the fields of gene editing, stem cells and immunology. I will develop an innovative platform to evaluate the impact of gene knockout across the process of cell reprogramming in human cells, comparing multiple cell conversion scenarios: pluripotency, multipotency (hematopoietic stem cells) and unipotency (dendritic cells). For this, I will carry out a CRISPR/Cas9 knockout screening coupled with next-generation sequencing using custom-designed sgRNA libraries targeting TFs, chromatin regulators, and RNA modifiers. After sequencing, I will determine the molecular targets that are relevant by comparing the three reprogramming systems. Genes involved in cell conversion will be defined as regulators of plasticity, and top hits will be validated to study their molecular mechanism and role. Certainly, RePLASTIC will open new research avenues on the basic principles of cellular plasticity and provide ground-breaking technologies that may contribute to immunotherapy, regeneration and cancer. I will pursue this project as an incoming researcher supervised by Dr. Filipe Pereira (Lund University, Sweden). During my stay, I will acquire hands-on expertise in cutting-edge techniques: direct reprogramming, hematopoietic/immune cells, gene editing, deep sequencing. I will also gain experience in mentorship and writing skills and expand my network by attending national and international meetings to present my work and foster new collaborations.

Keywords: degrees of plasticity,cellular identity,direct cell fate reprogramming,crispr cas9,hematopoiesis,dendritic cells,transcription factors
DIgital comPEtitive next Generation Aviation technologies for SUStainable business models, products and services. (Di-PEGASUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Ireland,France,Portugal,Cyprus,United Kingdom,Netherlands
Call: Digital aviation technologies for new aviation business models, services, emerging global threats and industrial competitiveness (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 4242587.5
EU funding (EUR): 4242587.5
Participants: 14
Project status: SIGNED

Di-PEGASUS overall objective is to enable fully autonomous cost-effective and environmentally friendly operations for seaplanes, VTOL and drones. This objective will be achieved by developing several enabling technologies targeting both the air and the ground side. In addition, Di-PEGASUS proposes to develop a digital platform to evaluate the viability of specific business models at particular locations, according to the digital technologies available, and the Key Performance Indicators (incl. cost-effectiveness, job creation, emissions savings, investment costs), in order to make recommendations to policy makers and relevant stakeholders that will host these services. This platform should also support the assessment of regulatory compliance to identify the safety assurance process that the technologies will need to follow, as well as the gaps in existing regulations that will need to be addressed.

Keywords: urban air mobility,seaplanes,uas,drones,impact assessment
Sustainable, Biobased and Bio-Inspired Materials for Smart Technical Textiles (SUBBIMATT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Belgium,Spain,Italy,Greece,Sweden,Türkiye,United Kingdom,France,Portugal
Call: Bioinspired and biomimetic materials for sustainable textiles (IA) (HORIZON-CL4-2023-RESILIENCE-01-TWO-STAGE, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 7722302.5
EU funding (EUR): 6617386.75
Participants: 15
Project status: SIGNED

In SUBBIMATT we will develop a novel generation of biobased and bioinspired sustainable smart technical textile materials to address current and future energy needs. We start from developing debondable adhesives, bio-polyurethane and negative thermoresponsive materials. Complementing these with existing (but tuned) biobased materials will enable circular textile intermediate products: high end coated fabrics, nanomembranes and shape memory filaments. Subsequently, these textile intermediates will be the stepping stone for making bioinspired Smart Textile Materials (STM) featuring mechanical actuation, energy harvesting and tuneable fabric openness. Lastly, the novel bio-STMs will be implemented in three demonstrators with integrated energy harvesting: shape morphing building envelopes, automotive interior textiles and advanced garments with adaptable breathability. The Safe and Sustainable by design (SSbD) framework will be applied, developing a protocol for technical textiles development. Combining modelling and experimental characterisation will allow to optimise the development of the STMs and demonstrators, predicting their safety, functionality and energy harvesting capabilities. For the demonstrators we plan to integrate complimentary elements (e.g. sensors, batteries or supercapacitors) resulting from other projects (via liaison). SUBBIMATT results will help to find more sustainable ways for covering the most important consumer living standard needs: energy, sustainability and comfort. The demonstrators will be products that citizens use on a daily basis, thus helping to increase visibility and impact. That way, we aim to create a positive momentum for the novel generation of smart biomaterials and for their application in bioinspired technical end-uses, thus helping the EU (technical textile) industry to remain competitive and become more resilient while transiting to a climate-neutral and circular economy.

Keywords: chemical engineering,bio polyurethane,thermoresponsive materials,debondable adhesive,energy harvesting,shape morphing membranes,extrusion,coating and finishing,electrospinning
Safe-, sUstainable- and Recyclable-by design Polymeric systems - A guidance towardS next generation of plasticS (SURPASS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: France,Spain,Hungary,Germany,Netherlands,Belgium
Call: Safe- and sustainable-by-design polymeric materials (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 4992239.76
EU funding (EUR): 4980559.29
Participants: 14
Project status: SIGNED

Plastic waste outlive us on this planet as they take centuries to break down. Endocrine disruption, land, air and water pollution are only some of the adverse effects of plastic waste on public and environmental health. Still, 70% of plastic waste collected in Europe is landfilled or incinerated. The overall objective of SURPASS project is to lead by example the transition towards more Safe, Sustainable and Recyclable by Design (SSRbD) polymeric materials. The SURPASS consortium of 14 partners consisting of research and technology organizations and industries will: 1. Develop SSRbD alternatives with no potentially hazardous additives through industrially relevant case-studies (TRL3-5) targeting the three sectors representing 70% of the European plastic demand: - Building: bio-sourced polyurethane resins with enhanced vitrimer properties to replace insulating PVC for window frames (? 40% C-Footprint reduction) - Transport: lightweight, therefore less energy-consuming epoxy-vitrimer (? 30% C-Footprint reduction), as alternative to metal for the train structure, anticipating emerging use of non-recyclable composites. - Packaging: MultiNanoLayered films involving no compatibilizers to replace currently non-recyclable multi-layers films (? 60% C-Footprint reduction). 2. Optimize reprocessing technologies adapted to the new SSRbD systems to support achievement of ambitious recyclability targets. 3. Develop a scoring-based assessment that will guide material designers, formulators and recyclers to design SSRbD polymeric materials, operating over the plastic?s entire life cycle, including hazard, health, environmental and economic assessment. 4. Merge all data and relevant methodologies in a digital infrastructure, offering an open-access user-friendly interface for innovators. SURPASS will in particular address its results to SMEs, representing more than 99% of enterprises, and therefore has an outstanding potential to contribute to the transition towards green economy.

Keywords: safety sustainability recyclability polymers plastics vitrimers additives films packaging building transport assessment environment health toxicity waste
Enhancing Sustainability in Biotech through Advanced Resin Regeneration for Protein Chromatography (EARTH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 986000.0
EU funding (EUR): 986000.0
Participants: 1
Project status: CLOSED

ReGenFix is a startup and academic spin-off specializing in regenerating chromatography columns, essential yet costly devices used in scientific research and industrial production of vaccines, drugs, and cosmetics. These columns often encounter contamination issues, resulting in waste, increased costs, and significant emissions. The biopharmaceutical sector, for instance, produces 13% more emissions than the automotive industry. To tackle this challenge, ReGenFix offers an innovative regeneration service using a proprietary formula that removes contaminants and restores columns to their original state. This solution reduces costs, maintains high-quality standards, decreases dependence on raw materials, and significantly reduces emissions. Aligned with the EU’s Sustainable Development Goals (Goals 9, 12, and 13), ReGenFix contributes to sustainable practices in the chromatography field. Since its inception in 2020, ReGenFix has attracted customers from research centers and universities in 13 countries across Europe and North America, established two partnerships with leading chromatography companies, and has been cited in the methods of several scientific articles. The company operates in the rapidly growing chromatography market, which is projected to reach €5 billion by 2025, and the chromatography resin market, which is expected to hit €2.3 billion by 2030. ReGenFix’s next steps include automating its regeneration process, scaling operations, and expanding its market presence. To achieve these goals, the company is seeking funding, primarily for automation. ReGenFix developed a one-of-a-kind solution that is revolutionizing the chromatography market. Our technology ensures high standards in reproducibility and consistency of results, avoids waste of money and resources, and helps protect the environment.

Keywords: fast protein liquid chromatography,columns,regeneration,resin regeneration,biotech,sustainability