Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling production-speed additive manufacturing at the micro-scale (Photosynthetic)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Photosynthetic B.V., founded in 2018 in Amsterdam, revolutionises microfabrication with its ultra-fast 3D printing technology, producing micro- and nano-structures with feature sizes under a micron. Awarded the Formnext Start-Up Challenge, Photosynthetic aims to lead the next generation of microfabrication, significantly impacting health and other sectors. Our mission is to revolutionise microfabrication by enabling efficient industrial-scale production of microstructures, unlocking new product possibilities, especially in health. We plan to set the standard for manufacturing nano- and micro-structures, starting with microfluidic devices like Microneedle Array Patches (MAPs) for drug delivery, micro-porous membranes for cell analysis, and bio-scaffolds for tissue engineering. Current microfabrication methods are slow, expensive, and limited in complexity. Photosynthetic’s Volumetric Micro-Lithography (VML) technology overcomes these challenges, enabling rapid production of complex 3D geometries with sub-micron precision. VML is based on single-photon polymerization, and is 1000 times faster than Two-Photon Lithography (TPL). It forms entire objects simultaneously, offering high resolution and speed. Photosynthetic’s technology addresses needs in pharmaceuticals (MAPs for vaccine delivery), cosmetics (microneedles for drug delivery), public health (mass immunisation), biotechnology (micro-porous membranes), and research (custom scaffolds). Revenue comes from printer sales and printing services. We promote green manufacturing through reduction of the material usage, and shortening of time-to-market. The technology enhances Europe’s technological independence and creates high-value jobs. We are seeking €2.5 million in EIC grant funding and €6 million equity (€3 mln EIC + €3 mln other VC) to complete, test, and commercialise its technology. The funds will support hardware upgrades, material improvements, and scaling production processes.

Keywords: additive manufacturing,microscale,lithography,optical systems,new materials,3d printing,volumetric micro lithography
Mechanism and significance of de novo gene methylation during reproduction in Marchantia (EPIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-16
End date: 2026-12-15
Duration (months): 40.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: SIGNED

DNA methylation plays fundamental roles in gene regulation and cell identity in plants and animals. However, these two kingdoms exhibit distinct methylation patterns and reprogramming of methylation during development occurs in different ways. I have exciting evidence from the emerging model plant system Marchantia polymorpha of de novo DNA methylation at thousands of genes in the embryo that is analogous to gene methylation established in the oocyte of mammals. A subset of these genes are also methylated in the Marchantia male sex organ prior to fertilisation and are enriched for roles in hormone signalling, epigenetics, and developmental transitions, indicating parental imprinting events important for embryo development. I propose to conduct a targeted dissection of this phenomenon. I will be hosted first by Prof. Ecker (Salk Institute, US), who is a world leader in single cell epigenomics. I will carry out high-throughput single cell methylomics and transcriptomics in combination with other cutting-edge molecular techniques to precisely determine the developmental processes undergoing gene methylation reprogramming as well as the underlying epigenetic players involved. In the return phase, I will be hosted by Prof. Solano (Centro Nacional de Biotecnología, Spain) who is an expert in motif analysis and Marchantia hormone biology. With his expertise I will investigate the methylation targeting mechanism and will utilise methylation loss lines to confirm the role of gene methylation in transcriptional regulation as well as development, with a focus on ethylene signalling. This proposal represents a state-of-the-art class of study of DNA methylation through which I will broaden my scientific knowledge, develop complementary skills such as lab management and science outreach, and extend my professional network internationally. The experiences gained during this Fellowship will be essential to achieve my goal of leading a research group at the forefront of epigenetics.

Keywords: dna methylation,meristem,zygote,fertilisation,imprinting,single cell analysis
Sloyd - Sustainable GenAI for 3D and Virtual Worlds (Sloyd - GenAI for 3D)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2200000.0
EU funding (EUR): 2200000.0
Participants: 1
Project status: SIGNED

Virtual Worlds are emerging as a critical platform for the future of entertainment and virtual collaboration, transforming how we connect, work, and play. Recent breakthroughs in GenAI have revolutionized text and image creation, setting the stage for similar advancements in 3D technologies. Existing GenAI solutions for 3D are often power and CPU-intensive, leading to excessive energy consumption and environmental impact. Additionally, they do not yet generate high enough output quality for use in Virtual Worlds, and take too much time to generate full worlds. To ensure sustainable growth and widespread adoption of 3D GenAI technologies, more lightweight solutions are necessary. These solutions must deliver high-quality 3D experiences without excessive resource costs, ensuring accessibility and environmental sustainability. In this project, SME Sloyd proposes a hybrid solution from parametric 3D modeling and AI that balances computational demands with efficient resource usage. By integrating lightweight techniques with advanced AI capabilities, we are building a scalable, sustainable framework for high-quality 3D experiences. The EU is uniquely positioned to lead in developing and deploying next-generation 3D GenAI technologies. By supporting this project, the EU can establish itself as a global leader in sustainable 3D innovation, driving both technological advancement and environmental responsibility. In summary, we aim to address the critical need for sustainable, scalable solutions in 3D GenAI. By leveraging recent advancements and focusing on lightweight, hybrid technologies, we can ensure that the future of Virtual Worlds is both innovative and environmentally sustainable. This project is a reply to the Challenge IV.2.2: Enabling virtual worlds and augmented interaction in high-impact applications to support the realisation of Industry 5.0

Keywords: virtual worlds,3d,generative ai,synthetic data,robotics,ai vision
DEVELOPING THE FIRST GAME-CHANGER IN THE STOMA-CARE MARKET: AN INNOVATIVE LEAK-PROOF AND ADHESIVE-FREE STOMA DEVICE (StomTop Ltd.)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

StomTop is transforming the stoma care market with its novel SilTop device, a revolutionary adhesive-free and leak-proof solution. For over 70 years, traditional stoma devices have relied on adhesive-based technologies that often fail, leading to leaks, skin irritation, and frequent, uncomfortable replacements. StomTop’s innovation lies in its internal sealing mechanism, which creates a secure, leak-proof fit without the need for adhesives, directly addressing these persistent issues. This technology utilizes the natural structure of the stoma to form a seal, preventing leakage and reducing skin complications such as irritation and peristomal skin complications (PSC). The non-adhesive external baseplate further enhances comfort, providing a stable attachment for the collection bag. SilTop’s design allows for a quick, 2-minute replacement process, empowering ostomates with the independence to manage their devices on their own without assistance. Unlike traditional devices, which require replacements every 1-3 days, SilTop can last up to 25 days, reducing daily disruptions and offering a major improvement in quality of life. This innovative approach not only solves longstanding problems with existing solutions but also introduces a new benchmark in stoma care. StomTop is led by a team with over 25 years of experience in medical product development and commercialization. Gender and social equity are central to the company’s values, with women in key leadership roles, including the CEO and Chief Medical Officer. StomTop’s vision is to redefine stoma care, empowering ostomates to lead more confident, comfortable lives with a reliable, easy-to-use solution. With the global ostomy care market projected to reach €5.86B by 2031, StomTop is poised to make a significant impact. By solving the issues of leaks, skin damage, and social stigma that have plagued the market for decades, SilTop offers a transformative alternative that will reshape the future of ostomy care worldwide.

Keywords: ostomy,stoma,ostomates,medical device
Spatiotemporal dynamics of secondary metabolism in the ocean microbiome (SPADYN-SM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: TERMINATED

Microbial secondary metabolism (SM) is critical to ecological interactions because it is a source of bioactive products such as antibiotics and anti-cancer drugs. Marine microbes are prolific sources of these compounds. Until now, the prospection of biosynthetic gene clusters has primarily focused on cataloguing SM diversity by using machine learning (ML) tools, with little regard to their importance for the microbial dynamics. Microbes benefit from SM by providing a chemical language for inter-specific communication and improving environmental interaction. The dynamics and evolutionary aspects of this interaction, as well as its effects on spatiotemporal microbial dynamics, have not been studied due to a lack of suitable datasets. To elucidate this, the SPADYN-SM project aims to investigate the spatiotemporal dynamics of SM in the ocean microbiome using an innovative genome-resolved work frame to verify diversity, mutations, selection pressures, and effects on environmental variables in a collection of metagenomes from monthly marine samples collected by the host and collaborators over a 7-years period. Dr. Santos will combine his unique expertise in biochemistry, molecular biology, bioinformatics, and ML with the host's notorious experience in microbial ecology and evolution to document the fluctuation of SM in marine microbes for the first time on an unprecedented temporal scale. SPADYN-SM could lead to a better understanding of seasonal patterns of SM in marine microbes, environmental effects, and possible impacts on microbial evolution. SPADYN-SM continues to advocate for the analysis of polymorphisms at the protein structure level, which may lead to the discovery of novel drug-like compounds. This highly interdisciplinary project, with its international collaborative network and innovation, will advance the EU's research and policy strategies, such as biotechnology and microbial community modeling fields, and will boost Dr. Santos' promising carreer.

Keywords: marine microbiology,biotechnology,machine learning,bioinformatics,secondary metabolism,spatiotemporal dynamics
Building a European strategic Research and Innovation Area in Direct Synergy with EU and International Initiatives for Pandemic Preparedness (BE READY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Coordination and support actions
Countries involved: Italy,France,Luxembourg,Norway,Poland,Portugal,Sweden,Netherlands,Belgium,Spain,United Kingdom,Austria,Denmark,Germany,Hungary,Switzerland
Call: Building a European partnership for pandemic preparedness (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 2259300.0
EU funding (EUR): 1998894.0
Participants: 25
Project status: SIGNED

The COVID-19 pandemic has confirmed and further highlighted the importance of planning and investing in research and innovation well before a health crisis occurs. For this purpose, the main goal of BE READY is to build a consolidated European Research and Innovation Area that provides the foundation of the candidate European partnership for pandemic preparedness so to improve the EU's preparedness to predict and respond to emerging health threats by better coordinating funding for research and innovation at EU, national (and regional) level towards common objectives and an agreed Strategic Research and Innovation Agenda. The Partnership is expected to build on existing pandemic preparedness networks, and work in synergy with the Health Emergency Response Authority (HERA), in close collaboration with ECDC, EMA and other relevant international and European actors. BE READY is composed by 24 organisations from 15 countries with complementary expertise and policy area ranging from Public Health Organisations, Ministries (of Science, University, Health, Innovation or Environment) and Research Performing Organisations that ensures a cross-cutting, interdisciplinary Global Health and One Health approach.

Keywords: pandemic,preparedeness,engagement,sria,one health,research and health technology
Problem-based learning trajectories in discrete mathematics education (ProDiME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Our research project is inscribed into the domain of mathematics education (didactic of mathematics): a research domain at the interface of mathematics and social sciences. The project is based on the collaboration of three researchers: Katalin Gosztonyi as Experienced Researcher, assistant professor at the Eötvös Loránd University of Budapest; Viviane Durand-Guerrier as Principal Supervisor, emeritus professor at the University of Montpellier; and Simon Modeste as Co-Supervisor, assistant professor at the University of Montpellier. Our project is focused on the development and analysis of complex problem-networks which will then serve for the conception and implementation of problem-based teaching trajectories. We aim to develop an efficient modelling framework in order to construct, analyse and represent problem-networks and problem-based trajectories for mathematics education – both for research purposes and for supporting teachers’ work in planning their teaching processes. We focus more particularly on problem-networks and teaching trajectories in the domain of discrete mathematics: on their potential place and role in mathematics curricula; their values for conceptual learning as well as for the development of generic mathematical skills (related to problem solving, abstraction, proof etc); and their potential connections with other mathematical domains, including links between mathematics and computer science. A theoretical and epistemological work and a priori didactical analysis of examples of problem-networks will be combined with experimental research on teachers’ and students’ work with problem-networks. The theoretical background of the project combines theories of the didactics of mathematics from the French research tradition with current research on the Hungarian Guided Discovery mathematics educational tradition. Experiments will be realized in both countries.

Keywords: didactic of mathematics,inquiry based mathematics education,discrete mathematics education,theory of didactical situations,didactical engineering,theory of conceptual fields,series of problems
Development of novel strategies for alkyl organoboron preparation via boryl radical reactivity (BRADOCO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-03
End date: 2026-06-02
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Borylated molecules are some integral tools routinely used to aid molecular construction in both academia and industry. Their use in the Nobel Prize-winning Brown oxidation and Suzuki-Miyaura cross-coupling as well as Chan-Lam amination make them ubiquitous in organic synthesis. The invention of methods to form C–B bonds at sp3 carbons is of strategic importance to facilitate the preparation of saturated, hence 3D, molecules. As the pharmaceutical sector is aware of the greater clinical success of 3D molecules, developing methods able to prepare these materials is a topic of continuous scientific endeavour. Central to this quest is designing synthetic strategies able to deliver, in a divergent manner, building blocks that are stable and can be used in modular cross-coupling diversifications. This project seeks to substantially expand the fields of photoredox catalysis and boron chemistry by introducing a novel class of boryl radical precursors that will enable the generation and the use of these underdeveloped species in mainstream catalysis. This strategy will constitute a divergent platform for the generation of many novel 3D borylated molecules that will then be engaged in modular cross-coupling reactivity. Importantly, this project will provide access to materials that cannot be prepared by any other method. This research capitalizes on recent developments of the Leonori group that has experience in the generation and use of boryl radicals in synthesis. The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

Keywords: boryl radicals,cross couplings,organoboron synthesis
Destabilizing vascular colonization to stop meningitis (DESTOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2477250.0
EU funding (EUR): 2477250.0
Participants: 2
Project status: SIGNED

Before the antibiotic era chances of survival to bacterial meningitis were minimal. Nevertheless, nearly 100 years later, surprisingly little progress has been made and mortality rates currently remain unacceptably high (10-25%). Supported by clinical and experimental data, the central concept of the Destop project is that bacteria rapidly become insensitive to antibiotics during infection, which leads to treatment failure. We hypothesize that the emergence of such antibiotic insensitivity results from vascular colonization by Neisseria meningitidis i.e. when the bacteria adhere to the surface of the endothelium, proliferate and progressively occlude the vessel lumen. We propose to explore the mechanisms underlying four steps of vascular colonization that potentially alter bacterial sensitivity to antibiotics: (i) bacterial adhesion to the endothelium and auto-aggregation; (ii) colonization dependent changes in bacterial physiology, (iii) bacteria-induced plasma membrane deformation shielding adhering bacteria, and (iv) bacteria-triggered intravascular coagulation. For this, we will develop a multidisciplinary approach that involves: an in vivo humanized mouse model and innovative microfluidic devices - vessel-on-a-chip model and a bacterial confinement chamber. The Destop project will not only provide novel mechanistic insights in the meningitis pathogenesis process and allow to develop novel strategies to combat bacterial meningitis but also have broader impact by providing a better understanding of how tissues, as a context for infections, reduce the efficiency of treatment of numerous other bacterial pathogens.

Keywords: this project is highly multidisciplinary and is related to several fields,immunology,microbiology,structural biology,physiology and biophysics