Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Conductive Nanoeuctectogels: Self-Powered Nanobioelectrodes for in situ Neuroprotection in Stroke Recovery (NeuroNzyme) (NeuroNzyme)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 3
Project status: SIGNED

The NeuroNzyme project represents a pioneering effort to develop a cutting-edge, self-powered, and non-invasive nanoplatform designed to enhance stroke recovery through electrical stimulation and neuroprotective therapy. At the heart of this innovation is a dual-function nanoparticle that combines the roles of both a nanoelectrode and a nano-enzymatic biofuel cell. The core of this novel approach lies in the nanoparticle's ability to generate microcurrents through a process involving the collective action of thousands of these particles surrounding neurons. This electrical stimulation activates voltage-gated ion channels on the neurons, which plays a critical role in promoting the regeneration of nervous tissue following a stroke. By continuously providing these microcurrents, the nanoparticles help facilitate the repair and rebuilding of damaged neural pathways. These nano-enzymatic biofuel cells are powered by physiological fluids within the body. As they operate, they also offer a neuroprotective antioxidant effect by regulating the levels of reactive oxygen species (ROS). ROS are highly reactive molecules that can contribute to further neuronal damage if not properly controlled. By managing ROS levels, the nanoparticles help to protect neurons from oxidative stress, thereby contributing to a more favorable environment for recovery. Moreover, the nanoparticles are engineered with a specific enzymatic tandem embedded within a specialized nanogel. This nanogel features a deep eutectic solvent interpenetrated network, which is crucial for maintaining high enzymatic activity over extended periods. The deep eutectic solvent enhances the stability and efficiency of the enzymes, ensuring that the nano-enzymatic biofuel cells remain effective in generating electrical stimulation and providing antioxidant protection.

Keywords: nano enzimatic fuel cell stroke recovery electrical neurostimulation self powered nanoparticles
A Trustworthy Data Science Copilot (DSCP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Romania
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1620000.0
EU funding (EUR): 1620000.0
Participants: 1
Project status: CLOSED

Across Europe’s manufacturing and public sectors, organizations face mounting obstacles in realizing the potential of AI and Generative AI (GenAI). Poor data infrastructures, fragmented systems, and increasing regulatory complexity hinder their ability to prepare, validate, and deploy AI solutions efficiently and responsibly. Data scientists, ML engineers, and AI teams—the professionals driving these efforts—are constrained by workflows that combine code, data, and generative components. Current AI-assisted tools such as GitHub Copilot or Cursor are optimized for coding tasks, not for the intertwined challenges of data quality, model build, and GenAI deployment. This results in wasted time on debugging, documentation, and compliance, as well as an overall erosion of confidence in AI-assisted outputs. This creates a clear market opportunity for a new class of copilots that augment the entire data-to-model workflow. Etiq’s approach directly addresses this foundational gap by empowering data and AI/ML professionals to build, test, document, and validate both traditional and generative AI systems with speed and confidence. Grounded in fusing of LLM and graph neural networks, the technical approach integrates tightly an integrity layer that maps and verifies the real logic of data and code with a generative layer.

Keywords: bridging the trust gap in ai solving data science workflow inefficiencies for manufacturing and the public sector
Engaging approaches and services for meaningful climate actions (ClearClimate)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Serbia,Netherlands,Ghana,Spain,Poland,Italy,United Kingdom
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 1265000.0
EU funding (EUR): 1209800.0
Participants: 10
Project status: SIGNED

ClearClimate is aimed to create an International, Interdisciplinary, and Intersectoral (“3-i”) for creative scholars with strong theoretical and practical skills, needed to tackle the major challenges of the Climate Information Services (CIS) development. The focus will be on developing staff and partner skills in the areas of user-centred design and behavioural science coupled with improved computational techniques which in turn will offer more appropriate and efficacious CIS solutions. The researchers will upgrade their “soft skills” that will enable them to transfer effectively their knowledge to the productive world, thus fostering the European market to create innovation. These will result from a close partnership between the academy, providing the researchers with up-to-date training and knowledge on cutting-edge research on targeted multidisciplinary topics, and a group of industries, who will complete the competencies of the ERs and ESRs by exposing them to practical and real-life challenges in CIS development. The main domains of interest of the ClearClimate project lie in the interconnected areas of climate change and climate extremes, data visualization, decision sciences, communication, accessibility, eye tracking research methodology and visual attention models, and XAI, which are the most relevant disciplines for the development of the frameworks for effective CIS. Secondments, soft skills training, exploitation of scientific results, dissemination, and public engagement, play also a central role in this network since they are designed to promote the dissemination of excellent research and diffusion of innovation in Europe. The creation of such an international, cross-sectoral, multidisciplinary, and life-long network of ERs and ESRs, trained across sectors in an innovative way, will direct Europe to strengthen its international R&I.

Keywords: climate system services,communication,climate extremes,neuroscience,accessibility
Sustainable Aluminium Reinforced Seawater Concrete (StARS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: CLOSED

Freshwater is a very precious natural resource and it is widely reported that the world reserve of freshwater is fast depleting. This problem is becoming more complex due to development in infrastructure which is demanding more quantity of concrete and pressurizing freshwater resources. Focusing on this issue, this project utilizes seawater for concreting (mixing + curing) to conserve freshwater resources. But, the corrosion of steel reinforcement is inevitable with the use of seawater (due to chloride in the seawater) in concrete. Therefore, noncorrosive aluminium reinforcement will be used in this project to minimize the risk of corrosion. An invisible layer of Al2O3 on the surface of aluminium protects it from corrosion. Although, it is considered that the high alkalinity of concrete degrades this outer layer and corrode the aluminium. In this regard, the use of Supplementary Cementitious Materials (SCMs) as a partial replacement of cement is found beneficial. Due to the pozzolanic activity, SCMs consume Ca(OH)2 formed by cement hydration and keep the pH so low that the concrete can be reinforced with aluminium bars even with seawater. In this project, calcined clay, natural pozzolanic material will be used as an SCM in concrete. Hence this project focuses on the possibilities of using seawater in aluminium reinforced concrete and reducing the burden of utilising freshwater. In addition, the use of calcined clay will reduce the cement content which leads to minimise the CO2 emission in environment and ultimately this project will produce a more sustainable concrete for the future. Moreover, the present research capability of researcher (limited to basic assessment of non-reinforced concrete) will be boosted by the assessment of aluminium reinforced concrete for corrosion, carbonation and shrinkage in conjunction with micro-scale analysis. The project results will contribute to Europe's positioning at the forefront of sustainability.

Keywords: sustainable,aluminium,seawater,concrete,clay
Fighting cancer with next generation oncolytic immunotherapy in ovarian, head & neck, and lung cancers (Immune Checkpoint Response Enabling Adenovirus Technology ) (I-CREATE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 5073000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: CLOSED

TILT Biotherapeutics is a clinical-stage biotechnology company developing novel gene therapies for cancer. TILT’s lead asset, TILT-123, is an oncolytic adenovirus armed with two human cytokines: TNF alpha and IL-2. TILT-123 is now in several Phase 1 clinical trials in Europe, the U.S. and China. The asset has been tailored to immunologically heat up cold tumors. Multiple antitumor mechanisms are activated: direct immunogenic killing of cancer cells while sparing healthy cells, release of tumor epitopes, production of cytokines locally at the tumor, and stimulation of patient’s own immune system to attack cancer. This approach provides the tumor with presence of immune cells: a prerequisite for immune checkpoint inhibitors (ICIs) to work and benefit patients. The project objective is to provide a curative treatment option to patients with refractory cancer, such as the ovarian, head and neck, or lung cancer and secure a global pharmaceutical customer to take TILT-123 to the market.

Keywords: oncolytic virus,immune checkpoint inhibitor,ovarian cancer,lung cancer,head and neck cancer,cancer immunotherapy
Truly portable MRI for extremity and brain imaging anywhere & everywhere (NextMRI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Netherlands,Germany
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2494415.0
EU funding (EUR): 2494415.0
Participants: 5
Project status: SIGNED

Mobile medical imaging devices are invaluable for clinical diagnostic purposes both inside and outside healthcare institutions. Unfortunately, Magnetic Resonance Imaging (MRI), the gold standard for numerous neurological and musculoskeletal conditions, is not readily portable. Recently, low-field MRI companies have demonstrated the first decisive steps towards portability within medical facilities and vehicles, but the scanners' weight and dimensions are still incompatible with more demanding use cases such as in remote and developing regions, sports facilities and events, medical and military camps, or home healthcare. Within the Histo-MRI and PR Scanner projects, we have recently demonstrated in vivo images taken with a light, small footprint, low-field extremity MRI scanner outside the controlled settings provided by medical facilities, including the first-ever MRI images obtained at a patient’s home, and even in open air connected to a gasoline generator. This has opened a path towards highly accessible MRI under circumstances previously unrealistic. In this project we will take the necessary technical, industrial and entrepreneurial steps to tackle the massive deployment of low-field portable systems for point-of-care and bedside imaging in clinics large and small, home and hospice care, rural areas, sports facilities and events, field hospitals, or NGO and military camps, making MRI available to a large fraction of the world population with no or insufficient access. To advance towards this highly ambitious goal, the objectives of the NextMRI project include: i) expanding the current technology to both extremity and brain imaging; ii) improving the diagnostic capabilities with machine learning; iii) improving the portability and usability to meet end-user needs; iv) optimizing production costs; v) gathering medical evidence of the technology performance with clinical trials; and vi) developing a sustainable business case and model towards commer

Keywords: medical imaging,mri,low field mri,musculoskeletal mri,neuroimaging,physiotherapy,rheumatology,sports medicine,neurology
Understanding the molecular principles governing mRNP architecture (GOVERNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2171250.0
EU funding (EUR): 2171250.0
Participants: 1
Project status: SIGNED

Eukaryotic messenger ribonucleoprotein (mRNP) particles are the functional entities that carry genetic information to the protein synthesizing machinery. These ribonucleoprotein complexes are dynamic and diverse, as highlighted by the copious number of proteins and transcripts identified in global proteomic and transcriptomic studies. However, little is known about the composition and architecture of individual mRNPs, and how changes in mRNP structure relate to their function or to dysfunction. The GOVERNA project will address this gap in knowledge by purifying specific mRNPs and delving into their molecular and structural arrangement. With our preliminary data serving as a springboard, the project combines genomic tagging engineered to maintain the most physiologically relevant conditions, biochemical methods developed to preserve the integrity of transient ribonucleoprotein assemblies, and mass spectrometry and cryo-electron microscopy to identify the composition and architecture of mRNPs. We will zoom-in on a set of paradigms in RNA biology that not only sample the breadth of mRNP diversity, but are also powerful model systems for linking structural information and biological function. We will investigate the molecular features in the three-dimensional organization of nuclear mRNPs from S. cerevisiae and of translationally repressed mRNPs in early developmental stages in D. melanogaster and X. laevis. For mRNPs undergoing active translation, we will investigate the transitions of human beta-globin mRNPs in the course of a surveillance process connected to disease. By studying these examples, we will glean fundamental insights into global principles governing the packaging of mRNPs and the remodeling of their three-dimensional features throughout a transcript’s life-cycle. The cumulative output will illuminate a central node of eukaryotic gene expression that is also particularly timely and relevant given recent developments in mRNA-based therapeutics.

Keywords: messenger ribonucleoproteins rnp,mrna transport and localisation,mrnp maturation
SENSE. The New European Roadmap to STEAM Education (SENSE.)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Norway,Germany,Spain,Sweden,Denmark,Romania,United Kingdom,Italy,France,Estonia,Greece,Netherlands,Ireland
Call: Developing a STE(A)M roadmap for Science Education in Horizon Europe (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1719786.25
EU funding (EUR): 1719786.25
Participants: 17
Project status: SIGNED

SENSE. will deliver a flexible roadmap for future-making STEAM education across Europe to radically re-configure the education of young citizens, by connecting schools with life and society with work. The lack of an appropriate pedagogical methodology linking formal science education with experiences of life and work in informal learning environments is the main reason for the limited uptake of results from prior initiatives. To achieve its ambition, SENSE. puts forward, tests, and implements a groundbreaking methodology - SENSE.STEAM -, harnessing scientific and artistic inquiry with reflective feedback to promote real-world learning that is culturally relevant and meaningful to pupils in their local communities. SENSE.STEAM goes at the core of teaching innovation and nurtures institutional and curriculum change. Multi-stakeholder engagement supports three progressive levels of maturity of the roadmap: awareness, action, and advocacy. At each stage, the SENSE.STEAM methodology will be implemented as part of in-country STEAM Labs, each one focusing on developing materials and actions and evaluating their impact on each of the four key thematic areas of Digitization, Green Deal, Health and Work Readiness. The Labs operate as hybrid collectives, sharing experiences and deepening impact across EU regions. The central outcome of the project will be the production of The New European Roadmap to STEAM Education, which provides resources and materials produced through in-country and across-countries STEAM Labs, and via a digital hub, the STEAM Academy, designed to support STEAM beneficiaries to co-create and take forward educational innovation. In this way, SENSE. shifts the STEAM landscape towards a new standard of interactional inquiry, reforming science education, generating a continuum of learning from school to employment, and harnessing the potential of future STEAM professionals to deliver on the ambitions of the new European society.
A unique fermentation platform for the production of a local, circular, and sustainable alternative to palm oil from bio-waste streams (NoPalm Oil)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: Food from precision fermentation and algae (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 2
Project status: SIGNED

At NoPalm Ingredients, we aim to produce the first-ever sustainable, circular, cost-competitive, and locally-produced alternative to palm oil (and other vegetable oils). Our unique, fermentation-based bioprocessing technology platform that can turn agri-food waste streams into fermented oils & fats is instrumental to this effort. Palm oil is found in 50% of all supermarket goods and 70% of all personal care products. With the increasing global population, the global palm oil demand is expected to triple to 240 Mt by 2050. However, palm oil production is responsible for 1.5% of global GHG emissions and 2.3% of global deforestation. Due to this, the European Deforestation-Free Regulation now obliges (FMCG) companies to use sustainably produced (RSPO-certified) palm oil. Yet only ~17% of palm oil produced today is RSPO-certified. This percentage will decrease further by 10-40%, due to climate change-induced oil palm plantation yield losses. Our fermentation-based technology enables us to produce tailor-made oils/fats that can directly replace palm oil in food, personal care, cleaning, and cosmetics products. Uniquely, we use agri-food waste streams in our process as feedstock and we have 2-3x higher overall process efficiency compared to the state-of-the-art. Compared to palm oil production, our technology has 93.5% less CO2 footprint and reduces land use by 99.9%. Over the last decade, imported palm oil use constituted ~30% of all vegetable oil consumption in the EU. Our technology will provide the capacity to locally produce fermented oils that can directly replace palm oil imports and become a critical tool for ensuring food sovereignty for Europe. Our team of 18 is led by Lars Langhout (CEO), with 12+ years of experience in strategy consulting and innovation management, and Prof. Jeroen Hugenholtz (CTO), a renowned microbiologist and fermentation expert with 40+ years of fermentation experience.

Keywords: environmental and green technologies,fermented oils,yeast oils,circular economy,waste upcycling,food additives