Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Darwinian Chemistry Doctoral Network (DarChemDN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,France,Israel,Germany,Switzerland,Italy
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 2842459.2
EU funding (EUR): 2721304.8
Participants: 15
Project status: SIGNED

Darwinian evolution is unrivalled in its ability to invent, which Humankind has already exploited for various purposes such as plant and animal breeding and directed evolution of proteins. In these examples, evolution acts on living species or material derived from them, but so far it has not been possible to apply Darwinian evolution outside the realm of biological and some computational systems. The aim of the DarChemDN research programme is to develop Darwinian Chemistry by creating, for the first time, synthetic chemical systems that can reproduce and undergo open-ended Darwinian evolution. Our pioneering concept will be implemented in a joint effort by 10 doctoral candidates (DCs) working on (1) the identification and development of viable autocatalytic systems, (2) incorporating these systems into compartments (emulsions and coacervates) to couple autocatalysis to compartment growth and division and (3) integrating metabolism in the new systems, to (4) enhance evolvability and achieve Darwinian evolution. We have assembled a consortium of scientific excellence that brings together multiple ERC grant holders, supervisors of several previous MSCA-ITNs and highly innovative companies with complementary expertise to deliver this unique research and training programme. Exploiting the full potential of the envisioned scientific breakthroughs requires a structured training programme to equip the first generation of Darwinian Chemists with advanced scientific, business, and transferable skills. In the long-term, we envision that the DarChemDN DCs will unleash the power of Darwinian evolution to have a profound impact on applied chemistry and materials science in areas ranging from catalysis to sensing and signalling by allowing optimisation of functions through evolution.

Keywords: systems chemistry,darwinian evolution,autocatalysis,self replication,coacervates,droplet microfluidics,reaction networks
INnoVAtive Solution for Imaging of Infiltrating mONocytes (INVASIION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2026-01-31
Duration (months): 42.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

The societal burden of brain disorders, such as multiple sclerosis (MS), Alzheimer’s and Parkinson’s disease is enormous and is considered one of the world’s most important health challenges. They affect millions of people worldwide and the annual healthcare costs are high and are increasing with the aging population. There is an immediate need to better understand the underlying molecular mechanisms of these disorders. Inflammation is widely recognized to play an important role in many neurological disorders. Next to the response of microglia, the resident immune cells in the central nervous system (CNS), infiltration of monocytes from the blood occurs, but the exact role of monocyte infiltration and the interplay between microglia and monocytes in vivo is still largely unknown. Clinical trials with chemokine receptor type 2 (CCR2) antagonists, aiming to reduce recruitment of monocytes and thereby reducing neuroinflammation, do not show clinical efficacy. Together, this emphasizes the need to unravel the role of infiltrating monocytes in human disease in vivo. Positron emission tomography (PET) is an imaging technique well suited to serve this purpose. I propose to develop new PET tracers targeting CCR2 as a tool to visualize infiltration of monocytes in the CNS in vivo to help elucidate their role in disease. Newly developed tracers will be evaluated in vitro, ex vivo and in vivo in an animal model of MS. A successful PET tracer will contribute to a better understanding of monocyte infiltration in disease in vivo and could ultimately serve as an important tool to guide drug development and evaluate novel disease-modifying therapies and therapies inhibiting monocyte infiltration. On a personal level, the proposed project will have a significant impact on my career, as new skills in neuroimaging, computer-aided drug design and in vitro target validation techniques will complement my previous expertise in organic chemistry, radiochemistry and PET tracer development.

Keywords: pet imaging,infiltrating monocytes,neuroinflammation,multiple sclerosis,ccr2 antagonist
Mera - Ethical, accurate drug development (MEra - Micro Era)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2026-01-31
Duration (months): 28.0
Total project cost (EUR): 4158818.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Using patented fluid management technologies, the Mera system has the ability to culture, drug & stain 3D tissues on a large scale while monitoring everything in real time, through a fully automated florescent microscope. 3D microtissues are added to a dedicated consumable bio-plate. The plate is then integrated into the main Mera system. A chemical cocktail can be introduced to selected wells on a plate in order to mature the cells into different tissue types such as liver, heart, neuronal or cancer. The fluid pathway can be changed to allow the introduction of a drug or stain to batches of multiple different tissue types. The fluid can then be recirculated, replicating the conditions in the human body where organs interact with each other. The whole process can be monitored using the automated microscope in wide field or florescent modes. The system is modular & scalable, allowing a single unit to run up to 800 microtissues simultaneously.

Keywords: personalised medicine,high throughput screening,predictive drug discovery,microphysiological systems mps,organ on a chip ooc,microfluidics,3d cell culture,automation and control systems,automation
Understanding the Role of Economic Imagination for Advancing Decarbonization in Europe (REIMAGINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1499875.0
Participants: 1
Project status: SIGNED

How do we imagine the decarbonized economy of the future? While research suggests that opposition to climate mitigation is often driven by economic concerns, we have little systematic knowledge of how decarbonization is actually imagined as a socio-economic transition, nor do we know about the economic images, symbols, narratives and assumptions underlying such visions and fears. REIMAGINE brings economic sociology’s recent interest in economic imaginaries and imagined futures to the study of climate (in)action. Its overall aim is to comparatively analyze and theorize how economic imagination fuels conflicts, frictions and impasses of decarbonization in Europe. A novel theoretical framework centers on social imaginaries of the economy, a concept describing shared representations of what the economy is and ought to be. It allows capturing and comparing economic imagination related to decarbonization, but can also explain enduring contestation with reference to dissonant economic imagination: visions of decarbonization that convey contrasting understandings of the economy restrict resonance between positions, make it hard to form coalitions or even recognize mutual interests. Substantiating this framework, an ambitious mixed method analysis explores decarbonization controversies within and across five EU societies (Ireland, Germany, Poland, Sweden, Spain). We will a) analyze media discourses and imagery to understand national frictions and develop a typology of decarbonization imaginaries; b) guided by visual prompts, interview local and national representatives from business, administration and climate initiatives to understand how economic imagination plays into conflicts of implementing decarbonization; c) apply correspondence analysis to interview results to chart major European fault lines and surprising coalitions. Overall, the project advances our interdisciplinary understanding of decarbonization and reveals challenges to a common European mitigation strategy.

Keywords: imagined futures,economic imagination,economic sociology,decarbonization,imaginaries
The Age of Civil Wars in Europe, c. 1914-1949 (CivilWars)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2499940.0
EU funding (EUR): 2499940.0
Participants: 1
Project status: SIGNED

In the first half of the twentieth century, Europe experienced an unparalleled number of civil wars resulting in millions of deaths. Civil war, as much as inter-state war, was a defining feature of the period for many European societies, from Ireland in the west and Russia in the east, to Finland in the north and Spain and Greece in the south. Since the 1990s, a rich and increasingly sophisticated body of literature has emerged on individual incidents of civil war, ranging from military studies to social and cultural analyses. However, remarkably little comparative work has been undertaken on civil wars in this period. Even fewer studies have explored the connections between them – be it transfers of people, ideas, or practices – beyond their ideological tropes. This has resulted in a tacit assumption of exceptionalism, whereby each civil war is assumed to have been unique and self-perpetuating without any serious attempt to explain why that was so. This project challenges exceptionalist approaches to civil war. While it recognises that significant differences in causes, forms, and/or aftermaths existed between individual civil wars, it argues that those civil wars can only be fully understood as a phenomenon within a pan-European context. The project will therefore investigate the origins, courses, and legacies of European civil wars through a fully integrated team of scholars with complementary expertise on the Russian, Finnish, Irish, Spanish and Greek cases. This will enable comparison between these different conflicts, but it will also go beyond the nation-centric tendencies of comparative approaches to arrive at a better understanding of what made the first half of the twentieth century an era of civil wars in Europe.

Keywords: history of violence history of armed conflict modern european history
High resolution dual comb spectroscopy and ranging (HIGHRES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1987368.75
EU funding (EUR): 1987368.75
Participants: 1
Project status: SIGNED

Spectroscopy and metrology are amongst the most important applications of electromagnetic fields The very fast oscillations of light (up to 200 THz in the infrared) permit very precise distance measurements as well as broadband analysis of radiations emitted and absorbed by matter. The technologies have evolved tremendously over the years and, at the turn of the century, a ground-breaking technology was proposed. By using two sources of optical pulse trains (corresponding to optical frequency combs in the spectral domain), no moving parts would be required, and much faster measurements could be performed. So-called dual comb spectroscopy and ranging have had a very significant impact on their respective fields and have established capabilities in terms of speed and accuracy that are still relevant today. Yet some important limitations remain. Most importantly, there is a trade-off between resolution an acquisition time which is currently treated as a fundamental limit of dual comb systems. It prevents these systems from being used for high resolution spectroscopy or long-distance ranging, which are critical for some applications such as gas sensing or large-scale metrology. In HIGHRES, I propose a novel technique which permits overcoming this fundamental limit. I expect it will improve the current state of the art by as much as three orders of magnitude in terms of resolution (or distance). We will start by a theoretical analysis of the general principle we propose. We will then build a dual comb source with unprecedented characteristics based on soliton formation in driven fiber resonators. Finally, using this novel source, we will experimentally demonstrate two proof of principle applications which would greatly benefit from this novel technique, namely THz spectroscopy and very long-distance ranging.

Keywords: frequency combs thz spectroscopy optical ranging temporal solitons
A PeRsOnalized Prevention roadmap for the future HEalThcare (PROPHET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Coordination and support actions
Countries involved: Italy,Portugal,Spain,Sweden,Germany,Netherlands,United Kingdom,Austria,Belgium,Estonia,France,Hungary,Finland
Call: A roadmap for personalised prevention (HORIZON-HLTH-2021-STAYHLTH-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2812437.5
EU funding (EUR): 2812437.0
Participants: 22
Project status: SIGNED

"PROPHET - a PeRsOnalized Prevention roadmap for the future HEalThcare" will develop a Strategic Research and Innovation Agenda (SRIA) for Personalized Prevention, in order to support the implementation of innovative, sustainable and effective personalized programmes to prevent common chronic diseases. Technological biomedical advances (including omics data and digital tools) make risk stratification at the individual level possible. However, development of Personalized Prevention approaches must be accompanied by healthcare system transition, including citizen engagement, healthcare professional education and addressing organisational, social and legal issues. PROPHET will be centred around stakeholder engagement and the SRIA co-creation process in relation to three main strands of activities: Mapping, Assessment, and Building. Firstly, we will summarize, evaluate and discuss with the relevant stakeholders the extent to which all these new technologies can synergise (Mapping). Secondly, we will design a holistic framework (the PROPHET Framework) that will include all the necessary aspects to appraise Personalized Prevention approaches and their adoption by Public Health Authorities (Assessment). Thirdly, we will support the introduction of Personalised Prevention Programmes by providing guidelines for their design, engaging with healthcare professionals (especially those working with policy makers), and increasing health literacy at the population level on the benefits of Personalized Prevention (Building). PROPHET will liaise with other key current and forthcoming initiatives at EU level, such as ICPerMed, European Partnership (EP) PerMed, the CSA Beyond 1 Million Genomes (B1MG), and the EP on Transforming Health and Care Systems. The consortium consists of 18 beneficiaries and 2 affiliated entities across 12 EU Countries, and a large number of stakeholders already engaged from different Target Groups.

Keywords: personalised prevention,chronic diseases,omics data,public health,citizen empowerment,health literacy,stakeholder engagement,health system sustainability,capacity building
Functional cOmposition of post quantum Cryptosystems At Large (FOCAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Cyprus,Greece,Germany,Israel,France,Switzerland,Belgium
Call: Post-quantum cryptography transition (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 6484718.75
EU funding (EUR): 6484718.75
Participants: 15
Project status: SIGNED

The FOCAL project will deliver a unified framework to achieve practical E2E functional composition of PQC in edge networked environments. Functional composition will be accommodated under a cross-layering paradigm mapping requirements of existing PQC cryptosystems and further improving them through appropriate methodologies and mechanisms via considering device, software, networking and communication properties. Consequently, FOCAL will act as a cornerstone on achieving the first practical and programmable composition of PQC across the full E2E path between a given datacenter orchestrating cloud services to an edge deployment. This will be achieved through (i) crypto-agility via hardware reconfigurability , (ii) exploitation of communication channel properties on the edge, (iii) network instrumentation and orchestration via advanced software-defined technologies, (iv) enhanced PQC key generation, encapsulation and storage underpinned by hardware acceleration schemes, (v) lightweight synthesis of distributed Trusted Execution Environments (TEEs) amongst edge devices, and (vi) awareness of application-level interoperability requirements inferred through Machine Learning (ML)-driven edge device learning. The envisaged technical directions will be dictated by non-technical activities encapsulated within the FOCAL framework assessing metrics associated to measuring the transition of such edge-oriented ecosystems into PQC and on improving existing standards and policies through lessons learned. Thus, contributing significantly towards the EU objectives and guidelines as outlined in the EU Commission Recommendation on Post-Quantum Cryptography.

Keywords: hardware,adaptability,crypto,agility,pqc,network,instrumentation,orchestration,tee,interoperable,protocols,automotive,space,medtech,fintech,data,centers
Towards On-Chip Plasmonic Amplifiers of THz Radiation (TERAPLASM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Thirty years ago Dyakonov and Shur opened a new field in solid-state physics and electronics - plasma-wave electronics. They theoretically predicted that: i) in nano-transistors, plasma waves may oscillate at THz frequencies far beyond the devices’ cut-off GHz frequencies, ii) THz radiation can be detected by plasma nonlinearities, and iii) the current flow can lead to the generation of THz radiation. The detection part of the “plasmonics promise” was proven and nowadays THz plasmonic detector arrays are widely used. In the case of emitters, the task turned out to be considerably more complicated. Only recently (PRX 10, 031004, 2020; with my team’s participation) room temperature, current-driven amplification of incoming THz radiation has been demonstrated in an innovative double grating gate structures based on graphene, one of the most promising materials for plasmonics. These break-through results indicate that existing models of plasmonic systems should be reconsidered and that using new 2D materials or their heterojunctions with innovative geometries, may lead “Towards on-chip plasmonics amplifiers of THz radiation”, which is TERAPLASM’s main objective. The experimental methodology will involve fabrication and THz spectroscopy studies of graphene and alternative-to-graphene unique HgTe and GaN-based systems with a high mobility 2D electron gas. This will allow finding the physical mechanisms responsible for the observed THz plasmonic amplification and select the optimum systems for THz devices. In parallel, theoretical research will develop physical models of THz plasmonic amplification studied in the experimental part of the project. By conducting extensive technological, spectroscopic, and theoretical research TERAPLASM will aim to answer the old basic physics and electronics questions on the feasibility of on-chip plasmonics amplifiers of THz radiation, with important potential applications in wireless telecommunication, biosensing, security, and others.

Keywords: terahertz oscillation of plasmons,2d layer materials plasmonic system,on chip terahertz amplifiers emitters,2d layer based devices