Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracking epigenetic plasticity in circulating tumor-derived DNA to monitor drug resistance and guide personalized treatment in cancer patients (EpiGuide)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1998625.0
EU funding (EUR): 1998625.0
Participants: 2
Project status: SIGNED

Personalized therapy has revolutionized cancer care during the past decades, but still suffers from frequent drug resistance and relapse. A better understanding of drug resistance mechanisms and their timely tracking and prevention represent areas of urgent clinical unmet need. While novel or clonally selected genetic lesions including DNA mutations and copy number changes are well known causes of therapy failure, emerging evidence supports a role for non-genetic/epigenetic heterogeneity and plasticity in the selective process to escape the pressure of therapy. In addition to unravelling the mechanisms controlling this epigenetic plasticity to identify new therapeutic strategies, there is a growing need for novel tools to detect and monitor epigenetic heterogeneity and plasticity that currently do not exist. EpiGuide aims to establish a blood-based monitoring tool to trace epigenetic mechanisms driving drug resistance development during treatment. I will develop and optimize the EpiGuide assay, an analytic and computational pipeline that measures and monitors methylation and histone modifications of circulating cell-free DNA that tumor cells shed into the blood plasma. In a next step, the efficacy of the EpiGuide assay to detect epigenetic tumor cell state changes will be validated in mouse models and patient samples. The EpiGuide assay will also explore temporal and spatial dynamics of epigenetic switches related to drug resistance, and look for associations with clinical outcome. The long-term goal is to bring the EpiGuide assay into clinical practice for monitoring in clinical trials and personalized cancer care. Major impact of EpiGuide is expected for guiding patient-tailored and disease state-adapted therapies, with a specific benefit of earlier detection of evolving non-genetic tumor cell states leading to drug resistance.

Keywords: liquid biopsies epigenetic plasticity therapy resistance dna methylation histone modifications deconvolution
Scaling Democratic Innovations (SCALEDEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Coordination and support actions
Countries involved: France,Italy,Ireland,Germany,Austria,Denmark,Slovakia,Belgium,Colombia
Call: Testing and implementation of research results fostering democracy and governance (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2024-12-01
End date: 2028-05-31
Duration (months): 42.0
Total project cost (EUR): 4583690.15
EU funding (EUR): 3978895.51
Participants: 13
Project status: SIGNED

SCALEDEM aims at unlocking the uptake of democratic innovations born in R&I actions, in particular stemming from EU-funded projects. This is achieved by developing a scaling infrastructure, including policy roadmaps and an actionable Compass for scaling democratic innovations, based on a Grounded Theory of Scaling. SCALEDEM helps researchers, practitioners, and policymakers assess opportunities and barriers for scaling democratic innovations along four dimensions: scaling high (impacting laws and policy), out (impacting greater more and new people), deep (impacting cultures and identities) and in (impacting processes' quality). SCALEDEM starts by analysing innovative solutions developed in R&I projects on the issue of citizen participation and engagement in democratic governance, in particular Horizon projects whose end date is after January 2023, to develop a Theory of Scaling. Following a collaborative and interdisciplinary translation process in its Translation Hub, SCALEDEM deploys two ambitious Scaling Grounds in the forms of Twinning and Pilot Programmes. The Scaling Grounds test and encourage the uptake of democratic innovations by new end users, scaling the societal impact of those solutions further. SCALEDEM establishes iterative feedback and capacity-building mechanisms to support the replicability and adaptability of solutions in new operational environments and actionability of theoretical solutions. In parallel, SCALEDEM involves and nurtures a global community of end users. It leverages strategic partnerships with relevant R&I projects, initiatives, and networks, notably the Network for innovative solutions for the future of democracy, to overcome the fragmentation of knowledge, identify opportunities to increase synergies for capacity-building actions to policymakers, practitioners and researchers, and expand the societal and political impact of EU-funded research in the EU and countries from Global Europe.

Keywords: testing and uptake of randi solutions,democratic innovations,capacity and coalition building,translation formats,scaling infrastructure
Quantum Fluids-of-Light Turbulence in Semiconductor microcavities (Q-FLIGHTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Quantum fluids are an extraordinary category of physical systems where quantum nature reveal itself at a macroscopic level. Superconductivity, superfluidity and Bose-Einstein condensation are spectacular examples of macroscopic coherence effects in quantum fluids. Driven out-of-equilibrium, both classical and quantum fluids display turbulent behaviors. The main difference between the two is lying in the fact that quantum fluids possess an absence of viscosity, and the building blocks of turbulence phenomena, the elementary excitations named vortices, have to be quantized meaning that the phase circulation around their core has to be a multiple of 2pi. These two properties affect drastically the system's behaviors compared to the classical turbulent scenario where vortices are known to interact all together in a continuous manner and have the potential to redistribute the energy of the system at all scales. These brought the questions of how vortices are nucleating, interacting, and recombining in the quantum fluid opening the field of quantum turbulence. How the primordial fluctuations associated with the quantum nature of the system can influence the aforementioned vortex properties? Is their spreading of entanglement mediated by interactions in a turbulent superfluid leading to squeezing states? Having insights into the previous questions would allow to understand what is the main implication of the difference between quantum turbulence and classical turbulence. In this action, we propose to investigate these questions with a superfluid of light made of semiconductor microcavities. This system allows to realize full microscopic investigation of 2D vortex spatial distributions to unveil their statistics and their interacting/nucleating properties. Furthermore, by elaborating a new time sampling nonlinear detection we will evaluate spatiotemporal correlations spreading in the system with the potential to enter the deep quantum regime of quantum fluids.

Keywords: quantum turbulence,exciton polariton microcavities,correlation measurments
Universal building blocks for antigen presentation to uncover the flavivirus-directed antibody response (FLAVIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1687500.0
EU funding (EUR): 1687500.0
Participants: 1
Project status: SIGNED

Flaviviruses are a tremendous burden on global public health. The genus consists of yellow fever virus, dengue virus, and zika virus amongst others. These viruses threaten more than half the global human population and are spreading into new territories. The recent zika virus pandemic stresses the need for a suitable protein engineering toolkit to enable swift development of emerging flavivirus antigens for structural studies, serology and vaccine development. Moreover, the structural determinants of a neutralizing polyclonal antibody response are currently not well understood, in large part for a lack of suitable methods to address the complex interactions of multiple antibodies directed against a heterogeneous, glycosylated viral antigen. With FLAVIR I will use my unique expertise in both mass spectrometry and electron microscopy to develop a comprehensive structural proteomics toolkit for in-depth profiling of the neutralizing antibody response against flaviviruses. Using a combination of novel mass spectrometry-based antibody sequencing techniques, glycoproteomics profiling and electron microscopy, we will uncover how the polyclonal antibody response against flaviviruses is directed by key structural determinants of the Envelope glycoprotein that is displayed on the surface of infectious virions. We will develop new strategies to produce prefusion stabilized E-dimers and ultimately reconstruction of full icosahedral flavivirus-like particles from soluble components. The outlined strategies will be tested and streamlined for broad applicability across the flaviviruses so that it can be swiftly adapted for emerging species and strains. We will characterize our designs with state-of-the art mass spectrometry methods (native MS, mass photometry, HDX-MS) and electron microscopy. We will use these optimized antigens to uncover the role of antigen glycosylation in antibody binding, profile the serum antibody repertoire directed against the E-antigen and map ou

Keywords: serology structural proteomics
Tackling Water Theft: Forecasting Adaptation Surprises (WaterTheft)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Water theft claims between 30% and 50% of the global water supply, and despite policy efforts to tackle it, is still on the rise. The policy failure to tackle water theft has been attributed to the nonlinear adaptive responses by economic agents such as irrigators, which can affect and be affected by other socioeconomic (e.g., growing crop prices) and ecological processes (e.g., water scarcity) via feedback loops with cascading impacts that are difficult to foresee. This has led to adaptation surprises with unexpected policy consequences, which have increased rather than reduced water theft, thus depleting water bodies and hampering sustainable development. Here I aim to break new ground by developing a novel approach to forecast adaptation surprises in complex human-water systems. To this end, I will 1) combine microeconomic mathematical programming models with behavioral economic methods to forecast the nonlinear adaptive responses of individual agents over time; 2) integrate the behavior of individual agents into agent-based models and macroeconomic models to forecast nonlinear spatial trends emerging from human interactions at the local to global level; 3) endogenize these socioeconomic processes into human-water system models to forecast nonlinear socio-hydrological phenomena; and 4) use ensemble experiments to quantify scenario and modeling uncertainties, and forecast nonlinearities that may emerge or be amplified due to issues of model parameterization/structure or scenario design. These innovations will allow me to predict the emergence of nonlinearities and track their impact across coupled human-water systems, thus discovering adaptation surprises and their drivers. Methods will be empirically applied and tested in 3 living labs in Spain, Australia, and the US experiencing water theft.

Keywords: water scarcity,drought,water theft,coupled human and natural systems chans,nonlinearities,surprise
Emerging eco-active materials by sustainable tools from natural renewable residues (ECOSYSTEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Denmark,Italy,Cyprus,Switzerland
Call: Nature inspired alternatives for food packaging and films for agriculture (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4263116.34
EU funding (EUR): 3933653.13
Participants: 9
Project status: SIGNED

ECOSYSTEM will develop innovative, multifunctional biopolyesters and active bio-based ingredients using sustainable technologies, to be used as mulching films and food and pharmaceutical packaging, ensuring safety and sustainability throughout the bio-based value chain. the project will offer end-of-life (EoL) strategies of the developed eco-active products, promoting eco-friendly solutions in packaging and agricultural practices. To achieve its ambitious goals, ECOSYSTEM, led by FUNDITEC (FUND), will follow a collaborative circular strategy across seven key blocks, with nine specialist partners: 1) First, Agrifood Waste Supply such as berries and pruning, will be provided by AGRICOLA 2000 (A2-I) and MOUNTAIN BERRIES (MBP). 2) Then, production of cellulose, furfural, and lignin from the above waste using an integrated biorefinery will be done by CSIC; 3) With this raw materials, aromatic and aliphatic monomers will be synthesized via mechanochemistry and white biotechnology by CSIC and FUND respectively, 4) Active ingredients with bacterial and ethylene inhibition capacity will be developed from natural resources by CSIC using mechanochemistry, and with antimicrobial and biostimulant properties by FUND through white biotechnology. Soil-sensors will be developed by DTI; 5) A catalogue of new biopolyesters will be designed and developed by FUND using mechanochemical polymerization from the prepared bio-based monomers; 6) Once biopolyesters and active ingredients are obtained, bioplastic films and packaging for food and pharmaceuticals will be manufactured by AIMPLAS ; 7) The above eco-active products will be tested in a relevant environment by A2-I and MBP, and 8) EoL Solutions will be provided: recyclability (AIMPLAS), reusability (CSIC), and biodegradability (UNIFE) for the designed products. ECOSYSTEM will also be supported by TEMASOL to assess sustainability and environmental impact, and by KNEIA to manage the portfolio, communication, and dissemination activities

Keywords: bio based polymers biodegradability food packaging bio based polyesters end of life solutions sustainable farming active materials mulching films agricultural waste
PrEP-ing at the end of HIV/AIDS: an anthropological study of Combination Prevention and PrEP in Argentina (PrEP-ing)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

PrEP-ing focuses on the implementation of Combination HIV Prevention (CP), the most comprehensive strategy of the Joint United Nations Program on HIV/AIDS (UNAIDS) in the current global effort to “End AIDS by 2030.” CP targets key populations, whose identification coincides with a higher HIV prevalence. Based on the notion that these groups have not responded to more conventional methods, the preventive use of antiretrovirals is prioritized, making Pre-Exposure Prophylaxis (PrEP) its key component. Following a scale-down in wide-ranging policies and programs (formerly a hallmark of HIV/AIDS governance), this strategy entails a more circumscribed biomedical prevention framework, in which antiretrovirals become the “magic-bullets” that protect communities from HIV and new individuals from getting infected. Against this backdrop, PrEP-ing seeks to re-center subjects and social relations through an ethnographic study of the production of this global HIV/AIDS policy in the specific national setting of Argentina. Drawing on insights from critical medical anthropology and studies on global health governance, the anthropology of policies and science and technology studies (STS), I aim to show how global-local entanglements involving biotechnologies, institutions, policymakers, health professionals, activists and PrEP users, come together in the making of CP. Argentina, a middle-income country situated in the global “South” and considered a model in the Latin American region for its early and sustained response to HIV/AIDS will provide a unique scenario to explore this subject. The main objective of this project is to describe and analyze the production of CP by a variety of actors. Taking the implementation of PrEP as a starting point, I seek to explore the constellation of actors and activities involved in the enactment of such policy: from policymakers situated at national and international levels to local health professionals, activists and users’ situated experiences.

Keywords: medical anthropology,critical studies on global health,hiv aids,latin america
Neuron Soundware: detecting machine failures early combining sound, AI and IoT technologies (Neuron Soundware (NSW))

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-12-31
Duration (months): 35.0
Total project cost (EUR): 3655813.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

NSW is an AI-based acoustic and vibration diagnostic technology for early detection of broken machines and process monitoring, providing unparalleled insight into the operation of mechanical systems. Combined with its large-scale applicability and ease of use, it disrupts the way machines are diagnosed, facilitating industrial sustainability and catering to the needs of Industry 4.0. Our technology acts as an auditory cortex, understanding audio signals and detecting salient problems, delivering highly reliable results with 99.6% accuracy. NSW's integrated hardware with embedded edge software and cloud-based software platform automatically detects machine faults before other methods, preventing costly downtime and unnecessary maintenance. Our detection process utilizes our proprietary audio dataset, which contains terabytes of data and is continuously expanded with each new anomaly, improving the accuracy of the algorithms, the faults addressed and the types of machines.
Translational Research in Action for Cancer in regional Ecosystem (TRACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Research and Innovation actions
Countries involved: Portugal,Ireland,Poland,Serbia,Germany
Call: Experimental local action for EU missions: knowledge institutions as focal points of transdisciplinary research and innovation activities with European outreach (HORIZON-MISS-2024-CROSS-02, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 1992750.0
EU funding (EUR): 1992750.0
Participants: 9
Project status: SIGNED

TRACE | Translational Research in Action for Cancer in Regional Ecosystems aims to bridge the research-to-practice gap in effective cancer awareness and prevention programmes, with a focus on underserved populations, for the improvement of the quality of life of patients and survivors, by collecting and analysing evidence on their needs. TRACE will implement a translational research initiative to develop regional ecosystems in three countries: Portugal, Poland, and Serbia, aligning with the objectives of the EC’s Mission on Cancer. The project will focus on reinforcing the regional ecosystems around 3 Universities (UNL, GUMED and FTN) involving the quadruple-helix of stakeholders to integrate cancer research and data from universities and research institutes with local healthcare systems, small and medium-sized enterprises (SMEs), public services, and grassroots organisations towards evidence-based literacy and prevention initiatives. By fostering transdisciplinary collaboration between higher education institutions and regional stakeholders, innovative, co-created approaches to cancer prevention can be tailored to the specific needs of each country and region. Citizen Science, public health programs in underserved areas, awareness campaigns, and Living Labs will bridge the gap between research and healthcare by ensuring new knowledge and evidence-based innovations are developed, tested, and implemented in real-world settings. This reduces inequities and benefits underserved communities that face challenges accessing cancer care. Additionally, the creation of a common data-sharing platform and cascade funding through an Open Call will involve industry, health, and social providers, ensuring the sustainability of the engagement model. This model will be implemented in 3 ecosystems, allowing the local, regional, and national layers to be enriched by transnational exchange and mutual learning between countries at different maturity levels, expanding ecosystem growth

Keywords: translational research ecosystems quadruple helix stakeholders health equity underserved populations cancer prevention citizen science public health living labs