Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
QUAKE SAVER: Emergency System for Door opening in any critical condition. (QSave)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Italy
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A large geographical area of Italian territory, European and international level is known to be subject to natural disasters, such as earthquakes, hydrogeological, landslides. Unfortunately, in many cases, these circumstances have devastating effects on the population, on the basis of these events, the innovative proposal Quake Saver System (acronym QSave), anti-locking door system, it is proposed to strengthen the users' safety standards not only of high seismic risk and hydro territories, but also in the industrialized areas subject to greater stress (arson, attacks, and in some cases the production defects of the exit routes installed). The anti-locking door system, QSave, protected by an industrial patent (N. WO 2015/132758 A1), will soon become a certified anti-seismic system, not-structural, for escape routes, thereby enhancing the resilience of European citizens in cases of exceptional events caused by natural disaster. The QSave prevents the block of the opening door by structural failures, not only generated by earthquakes, but also from defects of building structures which affect the door frame. The QSave device, which is inserted at the top and bottom of the door, can be applied both to new doors to the existing ones. The device has been realized to not compromise the effraction safety of the doors. It does not underestimate the fact that the installation of the anti-lock system is a low cost solution, compatible with any type of locks and leaves intact the design of the door. Lately more and more are presenting the seismic events that jeopardize the security of entire communities/cities, and that is not easy social and economic recovery. The business opportunities that will be addressed after the preparation of an innovative BP, are the large-scale production and marketing of QSave system that will allow an increasing the level of employment youth and will be a little help to increase the G.D.P. (Gross Domestic Product) of European areas.

Keywords: earthquake,safety,security system
The modes and outcomes of interaction of (im) mobile Kurdish women with public space: a cross-cultural comparative study of different urban contexts (WomInPubS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-08
End date: 2021-11-26
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

In the literature, not much has been reported on Kurdish urbanism in Kurdistan (a region in the Middle East traditionally inhabited mainly by Kurds) in general and women’s public space in particular, especially its socio-spatial implications for their everyday lives. For this reason, its particularities have largely remained unnoticed in the urban research debates concerning the Middle Eastern region. This is especially important if we consider Kurdish women’s interaction with public space in a cross-cultural comparative study in different urban contexts that Kurdish women have experienced. They can narrate different kinds of engagement, the challenges they are confronted with and the strategies they have gained to overcome gender inequality leading to their self-empowerment in social life. There are hardly any specific analyses concerning the modes and extent of Kurdish migrant women’s interaction with public space in European cities, particularly how this new spatial context affects their social lives and their empowerment. The number of Kurdish people is increasing in Western European cities: Based on the prestigious Institut Kurde in Paris, the most current estimates indicate the presence of about 1.5 to 1.7 million Kurds in Western Europe, out of these about 850,000 to 950,000 in Germany and 80,000 to 95,000 in Austria. Consequently, this line of research requires more attention from both international and national contexts in order to understand the experiences, challenges and needs of these urban dwellers in design and production of inclusive public spaces that are suitable for multicultural groups and that provide the possibility of an intercultural dialogue. The results of this proposed innovative research project could help find ways of making better connections between their everyday experiences as (im) migrants and public spaces as a constituent element of their social lives.

Keywords: public spaces,kurdish women,comparative study,self empowerment,gender inequality
Development of Stimuli-Responsive Nanoparticle-carrying T lymphocytes in the Fight against Cancer (CellularNanoMachines)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-04
End date: 2022-01-03
Duration (months): 36.0
Total project cost (EUR): 240530.4
EU funding (EUR): 240530.4
Participants: 2
Project status: CLOSED

The cancer burden represents an overarching health problem and it is essential that EU institutions develop the next generation of diagnostics that overcome the inadequacy of current imaging strategies. Nanomedicine, defined as the use of nanotechnologies in medicine, offers extraordinary opportunities to address these unmet medical needs. The proposed research project endeavours to find effective anticancer diagnostics through the development of smart cellular nano-machines. The design will integrate white blood cells (concretely, tumour-targeted T lymphocytes) as living carriers of stimuli-responsive drug-loaded NPs. The tumour-homing T cells will facilitate NP accumulation in tumours until an internal/external stimulus triggers NP-release. The NPs will also possess imaging capabilities to visualize and monitor the injected formulations and confirm that the designed NPs target cancer cells in vivo. This approach aims to achieve highly versatile, selective and effective nanomedicine products that combine imaging and therapy for different types of cancer (theranostics). The strategy will provide anticancer materials compatible with industrial processes and personalized medicine. Thus, I believe the results arising from this work will place EU institutions in an unbeatable position to capitalize on the next generation of diagnostics, not only to boost the competitiveness of our industries but also to make positive changes in the lives of our citizens.

Keywords: imaging nanoparticles,molecular imaging,nanomedicine,theranostics,cancer diagnosis,cancer immunology
Sustainable Design of 3D-printed Responsive Interfaces for Electrically Monitoring Bistable (Supra)Molecular Switches: Towards 3D-printed Logic Gates (R3DINBOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: CLOSED

The ability of electronic devices to act as switches makes digital information processing possible. The current silicon-based semiconductor processors are fabricated according to a top-down principle. However, the need to scale down in the size of such electronic devices has prompted the search for molecule-based information processing components (Molecular Electronics), such as switching memories, sensors and logic gates. Concretely, within the past two decades, developments in Nanotechnology have shown the capabilities of molecules to perform some of the computational logic functions - relating to the concept of logical zeros (0) and ones (1) binary code - achieved in mainstream semiconductor technology. Molecular logic gates differ from the currently used semiconductor elements by small size, multifunctional nature and variability of input and output signals. Nonetheless, the transition of logic elements from mostly optical means for reading output signals to electronic transduction tools would be beneficial for developing many novel logic elements for information processing, (bio)sensing and actuation. Accordingly, the design, construction and miniaturization of molecular electronic systems capable of performing complex logic functions is a current challenge. Herein, 3D printing technology is presented as a promising tool to open up new horizons in the field of electronic devices in general, and molecular logic gates in particular. For this goal, a sustainable bottom-up approach has been devised for the development of the next generation of “intelligent” 3D-printed electronic devices - 3D-printed responsive interfaces -, where bistable (supra)molecular switches will be electrically read out on carbon-based 3D-printed conductive substrates as the proof. Accordingly, R3DINBOW is in strong agreement with the EU’s digital strategy, while helping to achieve its target of a climate-neutral Europe by 2050 and responding to the current needs of our Society.

Keywords: 3d printing technology,responsive interfaces,molecular switches,electrodes,logic gates
Mechanism, regulation and functions of genome folding through loop extrusion by cohesin-NIPBL (LoopMechRegFun)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1679465.0
EU funding (EUR): 1679465.0
Participants: 1
Project status: SIGNED

Since its discovery 150 years ago, DNA has been intensely studied. As a result, it is understood in some detail how genomic DNA is replicated, repaired and segregated, and entire genomes can be sequenced. However, how DNA is folded in chromosomes has remained a mystery. It has been proposed that this is achieved by a process called loop extrusion. This hypothesis proposes that SMC complexes, multi-subunit ATPases present in all kingdoms of life, reel genomic DNA into loops, thus bringing distant loci into proximity. This process is thought to have important structural and regulatory functions, such as the separation of bacterial genomes and the folding of eukaryotic DNA into loops and topologically associating domains (TADs), facilitating sister chromatid resolution, gene regulation and immunoglobulin gene recombination. We discovered recently that in vitro single molecules of the SMC complex cohesin bound to NIPBL (cohesin-NIPBL) indeed rapidly extrude DNA into loops at up to 2.1 kb/s. These results provided the first direct evidence for the hypothesis that cohesin generates chromatin loops and TADs by extrusion. However, the most fundamental questions relating to this process remain unanswered: What is the mechanism of loop extrusion? How is this process controlled? How does cohesin extrude chromatin fibers in cells, and how does this contribute to the processes mentioned above and to other functions? We are proposing to use our single-molecule loop extrusion assay and other techniques to address these questions. Answering these will be essential for understanding genome architecture and regulation, will provide insights into mechanisms of gene regulation and recombination, will reveal how SMC complexes function as molecular ‘motors’, and may provide insight into the etiology of human disorders caused by malfunctioning of cohesin and NIPBL, such as several widespread cancers, rare congenital ‘cohesinopathies’, and trisomies and spontaneous human abortions.

Keywords: cohesin,genome architecure,loop extrusion,molecular motors,single molecule imaging,smc complexes
Taming non convexity? (TAMING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 1450625.0
EU funding (EUR): 1450625.0
Participants: 1
Project status: CLOSED

In many important areas and applications of science one has to solve non convex optimization problems and ideally and ultimately one would like to find the global optimum. However in most cases one is faced with NP-hard problems and therefore in practice one has been often satisfied with only a local optimum obtained with some ad-hoc (local) optimization algorithm. TAMING intends to provide a systematic methodology for solving hard non convex polynomial optimization problems in all areas of science. Indeed the last decade has witnessed the emergence of Polynomial Optimization as a new field in which powerful positivity certificates from real algebraic geometry have permitted to develop an original and systematic approach to solve (at global optimality) optimization problems with polynomial (and even semi-algebraic) data. The backbone of this powerful methodology is the « moment-SOS » approach also known as « Lasserre hierarchy » which has attracted a lot of attention in many areas (e.g., optimization, applied mathematics, quantum computing, engineering, theoretical computer science) with important potential applications. It is now a basic tool for analyzing hardness of approximation in combinatorial optimization and the best candidate algorithm to prove/disprove the famous Unique Games Conjecture. Recently it has also become a promising new method for solving the important Optimal Power Flow Problem in the strategic domain of Energy Networks (as the only method that could solve to optimality certain types of such problems). However in its present form this promising methodology inherits a high computational cost and a (too) severe problem size limitation which precludes from its application many important real life problems of significant size. Proving that indeed this methodology can fulfill its promises and solve important practical problems in various areas poses major theoretical & practical challenges.

Keywords: global optimization,nonlinear,discrete and combinatorial optimization,hierarchies of convex relaxations,sums of squares hierarchies,control,optimal control,computational geometry
Surface modulation of wounds: heal by inhalants! Novel drug-based treatment for excessive scars and chronic wounds. (SUMOWO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-05-01
End date: 2017-12-31
Duration (months): 20.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The innovative concept of the ERC Starting Grant project “Keratinocytes and Matrix metalloproteinases: driving force of skin wound contraction?” was to use inhalants for skin wounds and it proved to be excellent and functional. Surface Modulation of Wounds (SUMOWO) with these anti-inflammatory, pro-migratory and anti-fibrotic compounds will be beneficial for chronic wound healing and reduce excessive scarring. This novel drug-based treatment strategy marks a novel era of wound care. A clinical phase 1 study on healthy volunteers is planned to show the product’s safety and tolerability for skin use – the first step towards clinical application. The goal of SUMOWO is to deliver clinical proof of concept, to provide a thorough market analysis with contact to key-players, to secure our intellectual property rights on an international platform, to accelerate commercial exploitation and ultimately, to restore patients’ life quality.

Keywords: excessive scarring,chronic wounds,leg ulcers,wound healing,surface modulation,scar prevention
Sharing Expertise and Experience towards sheep Productivity through NETworking (SheepNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Coordination and support actions
Countries involved: Ireland,Spain,Italy,Türkiye,Romania,Türkiye,France,France,France,France,United Kingdom
Call: Thematic Networks compiling knowledge ready for practice (H2020-RUR-2016-1, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 1995289.38
EU funding (EUR): 1991289.5
Participants: 11
Project status: CLOSED

SheepNet is a thematic network project about practice-driven innovation to improve sheep productivity (number of lambs weaned/ewe mated): a critical component of farmers’ income and therefore of the sustainability and attractiveness of sheep farming. SheepNet will establish durable exchange of scientific and practical knowledge among researchers, farmers and advisors, through a multi-actor and transdisciplinary approach at national and international levels and by the broad involvement of European Agriculture knowledge and Innovation Systems. This will promote the implementation and dissemination of innovative and best technologies and practices for the improvement of sheep productivity. To maximize impact and ensure a wide coverage of different farming systems, SheepNet will bring together six main sheep producing EU countries, plus Turkey, and Australia, New Zealand, and every relevant EU network. The project aims to: • produce a scientific, technical and practical knowledge reservoir through a combined "top-down and bottom-up" approach and the strong involvement of 45 innovative farms; • foster cross-fertilization through multi-actors workshops at national and international levels, a broad and interactive participation of the "sheep community" via social networks and an interactive platform; • develop an easily understandable support package of communication and learning material, web-based tools, interactive platform, designed to help both scientists and stakeholders and a strong interactions with the EIP AGRI Service Point will guarantee long-lasting and wide accessibility of the SheepNet results.

Keywords: sheep farming,multi actor approach,cross fertilization
The Molecular Dynamics of Membrane Contact Sites (MCS-MD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1497719.0
EU funding (EUR): 1497719.0
Participants: 1
Project status: SIGNED

The goal of this project is to obtain an atomistic structural and dynamical characterization of the inner workings of membrane contact sites (MCS) between intracellular organelles, in order to understand how molecular processes such as non-vesicular lipid transport at MCS might modulate lipid homeostatic processes at the whole-cell scale. Investigation of the mechanisms taking place at MCS has emerged as a central topic in cellular biology in the last few years, and it has led to a large amount of novel cellular, biochemical and structural data that has drastically revolutionized our general understanding of lipid homeostasis in the cell. Yet, due to limitations of experimental methods, a high-resolution understanding of how MCS proteins work is still limited, and the specific molecular details of these mechanisms are still under intense debate, and especially concerning the specificity of lipid transport or the discrimination between lipid sensing and lipid transport. To understand these processes with unprecedented molecular detail, I will develop high-throughput protocols based on atomistic and coarse-grain molecular dynamics simulations that leverage and take advantage of all the available, yet often scattered, experimental data. With these approaches, that have not been used so far to investigate MCS because of the extreme complexity of these cellular machineries, I will obtain a detailed understanding of key molecular processes taking place at MCS, including the specificity of membrane binding, the mechanism of lipid uptake and release, the influence of confinement on protein activity, and the role of membrane lipid composition in the regulation of lipid transport. This approach will drive forward our perception of the limits of structure-based in-silico methods, and it will contribute to our mechanistic understanding of key cellular biology processes by providing new quantitative results that are beyond the current possibilities of experimental approaches.

Keywords: membrane biology,molecular dynamics,lipid transport,protein dynamics