Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Embodiment of Racialization: Running Muslim Women and the Sense of Non-Belonging (EmbRace)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-15
End date: 2024-08-14
Duration (months): 24.0
Total project cost (EUR): 199014.24
EU funding (EUR): 199014.24
Participants: 2
Project status: CLOSED

Muslims are the focus of political anxieties in Europe and the US. Over the last decade, numerous studies have documented the racialization of Muslims, and the impact of those discourses on those identified as such. Yet the embodied and sensorial dimension of the racialization of Muslims remains largely under-theorized. EmbRace posits that to better understand, and by extension tackle, the effects of (racial) discrimination in everyday life, we need not only to attend to statistics of reported racism or narrated accounts of racism, but also to the sensorial and bodily experience of it. This project takes recreational running as a fruitful angle to consider the embodiment of race. The leisurely activity of running enables an investigation of the effects of racialization on the relation to one’s own body, environment, and to other people. The research design utilizes a multimodal ethnographic approach. To reveal the embodiment of social hierarchies in social interactions among Muslim recreational athletes, this project has two main objectives: 1) Conceptualize how dispositions of non-belonging shape outdoor activities such as running and vice versa, by analysing movement and narratives of movement (conceptual/empirical goal) and 2) To examine and theorize the processes through which the multisensory dimensions of racialization become embodied (theoretical goal). By proposing a knowledge transfer between the researcher, Leiden University (The Netherlands) and University of California, Berkeley (USA), this project aims to contribute to the theorization of embodied senses of non-belonging.

Keywords: racialization,embodiment,sport
Extending Design Thinking with Emerging Digital Technologies (Exten.D.T.2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Sweden,Greece,Belgium,Norway,Ireland,United Kingdom
Call: Integration of emerging new technologies into education and training (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-09-01
End date: 2025-11-30
Duration (months): 39.0
Total project cost (EUR): 2585135.0
EU funding (EUR): 2585135.0
Participants: 8
Project status: SIGNED

Exten.(D.T.)2 uses Emerging Technologies (ET) to enhance the pedagogical value, sustainable digitization and potential for wide deployment of Design Thinking (DT). DT is a promising transformative pedagogical innovation based on engaged interdisciplinary learning and the growth of 21st-century (21C) skills for everyone, through entrepreneurial co-creation. Like other such innovations however, it has yet to pull its potential weight in terms of impact in educational transformation. Exten.(D.T.)2 will use design-based research to support/provide evidence for pedagogical transformation via DT enhanced by ET. It will employ already institutionalized, home-grown and open-access digital expressive media of advanced technical readiness for students to engage in DT projects. It will also uniquely integrate with these expressive media ET i.e. ΑΙ-enhanced Authorable Learning Analytics, Augmented Reality, 3D printing/scanning and virtual robotics, to leverage digital implementation, monitoring and assessment of DT projects by teachers in schools. Implemented/developed in different social contexts across 6 European countries, Exten.(D.T.)2 will explore the risks and potential of the pedagogical use of ET and how they support 21C skills, in turn increasing the scope, transformative potential and applicability of DT with ET in mainstream schooling. Exten.(D.T.)2 will invite and inspire teachers and other stakeholders to design and implement such projects, by running original strategic teacher professional development, providing courses and guidelines for them to design, implement and evaluate DT projects in their classrooms. The Exten.(D.T.)2 consortium includes 8 research sites with complementary interdisciplinary academic expertise, to support project development and at the same time with maintained active and sustainable connections with educational institutions and policy-making centers across 6 European countries.

Keywords: design thinking emerging digital technologies co construction design pedagogical transformation inclusivity scaling implementation teacher education competence development
Engineered Nanomaterials as Adjuvants to Boost Neuroblastoma Vaccine Efficacy (NANO-ADJUVANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-02
End date: 2028-01-01
Duration (months): 24.0
Total project cost (EUR): 268568.64
EU funding (EUR): 268568.64
Participants: 2
Project status: SIGNED

Neuroblastoma (NB) is a rare, aggressive malignancy primarily affecting children under the age of 5. Despite significant advancements in treating NB, the disease remains a formidable challenge. A promising approach for NB treatment is the development of therapeutic cancer vaccines with innovative nanomaterial-based adjuvants. When used as adjuvants, nanomaterials offer several advantages, including efficient migration to lymph nodes, improved antigen presentation by dendritic cells, and cross-presentation to cytotoxic T cells. Numerous ongoing clinical trials for NB vaccines are investigating the combination of multiple adjuvants to enhance immune responses against target antigens. NANO-ADJUVANT focuses on developing innovative nanomaterial-based adjuvants, incorporating immune-stimulating elements to enhance anti-tumor immune responses. Using my expertise in nanomaterial formulations, I will develop novel selenium-based nanoparticles incorporating manganese and zinc. These nano-adjuvants will be designed to elicit balanced antibody and cell-mediated immune responses when combined with tumour-associated peptides. Mentor, Dr Piskareva’s experience in NB will be utilised for in vitro and in vivo studies to assess vaccine efficacy. During a secondment to Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Spain, I will perform the preclinical evaluation of vaccine efficacy in a NB mouse model under the guidance of Dr Segura. To characterise anti-tumour immune response at the molecular and cellular level, I will use the expertise of Centre for Systems Medicine (CSM) in my host institution (RCSI) by performing scRNA-seq and bioinformatics analysis. NANO-ADJUVANT aligns with Europe's Beating Cancer Plan, which prioritises improving outcomes for children with cancer. By developing innovative adjuvant formulations, NANO-ADJUVANT contributes to enhancing NB treatment and improving patient's quality of life.

Keywords: inorganic nano material compositions,adjuvants,therapeutic cancer vaccines,neuroblastoma
Building Virtual Worlds that Follow Universal Laws of Physics (Foundation)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999024.0
EU funding (EUR): 1999024.0
Participants: 1
Project status: CLOSED

Planetary climate models are essential to understanding the climate on Earth while also being windows into the many climates that may exist throughout the Universe. However, current models often fail to simulate planets that diverged from Earth-like conditions as they rely on Earth-centric formulations and suffer a shortage of first principle representations. This severely impacts our ability to understand and predict climate change and evolution, as the physical accuracy of the simulations is compromised. To solve this current gap in our knowledge, I will lead the development of the first planet climate simulator, Foundation. My central role in developing unprecedented 3D planetary atmospheric models from scratch sets me in an advantageous position to successfully lead this ambitious project. Our goal is to use the building blocks of physical processes we know occur in atmospheres, such as fluid flow equations, moist physics and cloud formation, and build up climate physics in a 3D model that achieves accurate simulations. Our novel model will address climate phenomena that remain unsolved in the Solar System due to current model limitations, namely the nature of Jupiter's chaotic atmosphere, Venus's deep atmospheric circulation and Titan's methane cycle. These are major gaps in our knowledge, even with more than 50 years of spacecraft data. A model based on Universal physics that can reproduce the most challenging climates of the Solar System is extremely valuable to evaluate Earth's climate model predictions. Our approach can strongly impact the robustness of Earth's changing climate simulations and the prediction of extreme weather events, which are becoming increasingly more critical to our living environment. Foundation's greater climate prediction capabilities will also revolutionise exoplanet atmospheric characterisation and provide a thorough theory on the climate stability of terrestrial planets, essential to our understanding of climate diversity.

Keywords: global circulation models,solar system planets,planetary sciences,venus,jupiter,titan,exoplanets,earth climate,climate physics
Infant Feeding Decisions in Two Cultural Locations (INFEDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-01-31
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

The aim of the project is to critically examine the factors influencing mothers’ decisions on infant feeding in two different cultural locations: Ireland and Finland and to provide innovative research on women’s experiences of breastfeeding and bottle-feeding. The project highlights that infant feeding decisions are not made independent of social and cultural context. There are two specific objectives: 1) To explore and identify the cultural expectations and policies concerning infant feeding in Ireland and Finland. This objective is the groundwork for RO2, and informants are people working and volunteering in breastfeeding associations and midwife organizations. 2) To research infant feeding as a contextual practice that has personal, cultural, and social levels. This is achieved by analysing the interview narratives conducted with mothers from both countries while being sensitive to intersectional differences and socially constructed subject positions. The research method is qualitative and has an interdisciplinary approach combining content analysis and narrative analysis methods with gender studies, media studies and sociology. An intersectional reading is used while analysing the data. The project contributes to the research of infant feeding and breastfeeding which is set as a health priority throughout Europe. The reasons behind breastfeeding or bottle feeding are various and this research adds knowledge and understanding to the different levels of infant feeding. The breastfeeding rates in selected countries are very different; in Finland over 95 % of mothers initiate breastfeeding while in Ireland the rates are much lower and little more than 60 % are breastfed. This makes Ireland’s breastfeeding rates one of the lowest in the EU. Still, both countries are affected by the savings targeted to maternity services, the lack of support in the early days of mothering, the pressures of profit gaining formula industry, and the constant sexualisation of breasts.

Keywords: mothering,infant feeding decisions,contextuality,intersectionality
DOMAIN-PHOS: Towards large-scale functional characterization of protein phosphorylation (DOMAIN-PHOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

In recent decades, phosphoproteomics has greatly advanced our ability to quantify protein phosphorylation. However, characterizing the functional consequences of these phosphorylation events remains challenging, with only ~6% of recorded events having an associated function. This project aims to bridge this gap by developing a high-throughput method for characterizing biochemical functions of phospho-events. The proposed approach, supported by preliminary data, leverages the fact that some protein domains recognize phosphorylation of other proteins, thereby defining the function of both the binder and the phospho-substrate. For example, 37 human proteins contain the phospho-binding Forkhead-Associated (FHA) domain, each with a slightly altered sequence influencing substrate choice. FHA proteins act in various processes, including DNA damage response and cytoskeletal movements, areas of expertise for the applicant. The project involves GFP-tagging all human FHA domains for use in affinity pulldowns, followed by mass spectrometry for comparative analysis of phospho-substrates. For validation, we will perform large-scale reciprocal phosphopeptide pulldowns, a technique developed in the host lab. The combination of the applicant's expertise and the host lab's methodology creates a strong synergy. To understand structure-function relations, we will model interactions of shortlisted FHA:phospho-substrate pairs using AlphaFold3. Additionally, we will conduct phenome-wide association studies to find links between mutations in interaction pairs and disease states, including the functional follow-up on disease-relevant findings. The appeal of this approach extends beyond expanding FHA domain biology, as it has the potential to generalize to other post-translational modification- (PTM-) binding domains. This method could start a field describing PTM-associated functions at scale, enabling easier causative linking of protein function, mutation, and disease.

Keywords: molecular biology,phosphorylation,protein domains,fha domain,affinity purification,alphafold,dna damage response,phenome wide association studies,disease mutations,cytoskeleton
UNDERSTANDING AND IMPROVING SOCIAL INCLUSION IN INDIAN PRIVATE SCHOOLS (EDINCLUSION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Sweden,India
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 2
Project status: SIGNED

Social and economic stratification of schools can hurt both the equity and effectiveness of education systems. These concerns are exacerbated in settings where private schools account for a significant share of enrolment, as is the case in India - where nearly half the population attends a fee-charging private school. The EDINCLUSION project proposes an ambitious research agenda focused on understanding and improving school integration in India - which is the world’s largest school system, and also among the most unequal. The agenda focuses on studying and improving the impact of India’s landmark school integration policy, under the Right to Education Act 2009, which mandates that 25% of places in private schools should be reserved for students from disadvantaged economic and caste backgrounds (with the government reimbursing fees). This is likely the world’s largest-ever school integration initiative, affecting several times as many children as school desegregation initiatives in the US in the 1960s. Yet, despite its importance, there is remarkably little research on either the impact of this policy or on ways to improve its effectiveness. The proposal features three work packages to address these gaps: (a) an assessment of effects on current beneficiaries, identified using the lottery-based allocation of seats in oversubscribed schools, (b) identifying approaches to encourage applications from poorer eligible students, evaluated through two multi-armed randomized control trials, and (c) a systematic understanding of private school markets using innovative survey design methods, panel data and exogenous policy-induced variation for identification. The results of this research program will generate ground-breaking evidence on (i) the effectiveness of this large school integration program (ii) identify scalable ways to improve its effectiveness and (iii) generate fundamental insights about the functioning of urban school markets in developing countries.

Keywords: affirmative action social inclusion education student learning india
Unraveling the Mysteries of Vibrational Strong Coupling (UnMySt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Israel,France,Germany,United States
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 9967125.0
EU funding (EUR): 9967125.0
Participants: 5
Project status: SIGNED

Polaritonic Chemistry is a new and exciting field that has emerged from the fusion of chemistry and cavity quantum electrodynamics. In this innovative realm, and specifically under Vibrational Strong Coupling (VSC), hybridizing molecular vibrations with electromagnetic cavity modes has been shown to modify the rate and yield of reactions, solvent polarity and other molecular properties, in the absence of any illumination. The prospects for VSC as a versatile tool for chemistry and materials science have sparked a worldwide surge of interest, leading to substantial advances in recent years. Nevertheless, deciphering the underlying mechanisms by which VSC affects material properties still poses formidable challenges, impeding the utilization of VSC to its full potential. The goal of UnMySt is to construct a complete framework for cavity-controlled chemistry, built upon a comprehensive mechanistic understanding of VSC on both the molecular and supramolecular levels. As leading scientists in the field, we will pursue this goal by joining our forces in seeking answers to these pivotal questions: 1. What is the mechanism that links the local character of molecular reactivity with the collective nature of VSC? 2. Do the thermal equilibrium properties of materials change under VSC and how are such modifications expressed in polaritonic chemistry? 3. What are the manifestations of VSC on non-equilibrium dynamics such as solvent reorganization or charge transfer? 4. Can symmetry considerations provide intuitive guidelines for cavity-controlled chemistry? Can symmetries imposed or broken by the cavity be used to tailor its impact on reactivity? Our synergistic experimental and theoretical efforts will reveal novel physical mechanisms and will lay the qualitative and quantitative foundations for the rational design of strongly coupled molecular systems. The results of UnMyST will unleash the potential of polaritonic chemistry as a new tool for synthesis and materials science.

Keywords: cavity polaritons,polaritonic chemistry,vibrational strong coupling,spectroscopy,electronic structure,molecular dynamics,electronic structure methods,quantum electrodynamics density functional theory
Validation of α-synuclein Modifications in Parkinson’s dIsoRder Evolution (VaMPiRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Romania,Greece,France,Poland,Australia
Call: Validation of fluid-derived biomarkers for the prediction and prevention of brain disorders (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2024-11-01
End date: 2029-04-30
Duration (months): 54.0
Total project cost (EUR): 9448164.65
EU funding (EUR): 7928632.83
Participants: 16
Project status: SIGNED

Parkinson's disease (PD) presents a complex challenge due to its progressive neurodegenerative nature, affecting various body systems. Despite decades of research, understanding its onset and progression remains unclear, complicating early diagnosis and treatment. Recent advancements in PD physiopathology suggest promising treatments to slow disease progression, yet reversing cellular degeneration remains elusive. With novel therapies emerging, the need for early detection tools is urgent. However, validated biomarkers for PD diagnosis are lacking, relying on subjective scales like Hoehn and Yahr or costly medical imaging techniques. The accumulation of misfolded α-Synuclein (α-Syn) proteins in PD pathology has sparked interest, but defining diagnostic roles requires further investigation. Recent findings of α-Syn in neuronal-derived extracellular vesicles (NDEVs) from PD patients suggest a potential for novel diagnostic methods. Our proposed project, VαMPiRE, aims to conduct a longitudinal study involving 600 PD patients and 600 healthy subjects to explore α-Syn isoforms and related biomarkers in NDEVs for early PD detection. We plan to develop and validate an innovative in-vitro diagnostic (IVD) test capable of detecting PD's earliest stages and estimating disease prognosis and progression. Utilizing AI models to generate data analysis algorithms and collaboration with leading analytical laboratories and IVD manufacturers, we aim to ensure the reliability and feasibility of the developed prototype. Through consortium efforts, we envision licensing the generated intellectual property to drive the commercialization of our results. This can improve early screening of 270,000 new cases of PD could be detected early and improve the disease management of 9.4 M people currently diagnosed of PD and avoid losing a total of 5.8 million disability adjusted life years (DALYs) by 2028 leading also the development of better treatments.

Keywords: parkinson s disease,pd,pd biomarkers,pd screening,neuron derived extracellular vesicles,ndev,alfa synuclein