Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Shaping the future of EPR with cryoprobes and superconducting microresonators (SPECTR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Lithuania,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2025-03-31
Duration (months): 34.0
Total project cost (EUR): 158597.76
EU funding (EUR): 158597.76
Participants: 2
Project status: CLOSED

Electron paramagnetic resonance (EPR) is a highly powerful tool employed across different disciplines including structural biology, material science, quantum information processing and many others. EPR provides essential information about a local unpaired electron spin environment, electronic properties and dynamics of various paramagnetic centers. However, a relatively low sensitivity of a conventional EPR often limits its applicability to study small-volume systems (e.g. single biological cells). Recently, major advances in the EPR sensitivity enhancement have been achieved in the field of quantum information processing using superconducting microresonators and low-noise cryogenic microwave preamplifiers. The full potential of this highly sensitive EPR approach to investigate typical spin systems in other areas still remains to be shown, which is critical for its wider application in different scientific disciplines. The main goal of this Marie Skłodowska-Curie project is adaptation of these developments to study conventional spin systems and their application to solve currently EPR-inaccessible intriguing problems in biochemistry. The spin systems to be studied include a miniature amount of spin labels, a single RNA-binding protein droplet and spins in a single bacterium. The researcher, dr. Mantas Šimėnas, will be employed in his home country (Lithuania) at Vilnius University (VU) under the supervision by prof. Jūras Banys. He will bring to VU a valuable experience on EPR of various spin systems, cryoprobeheads and microresonators gained during his postdoctoral fellowship at University College London. During the project, the researcher will grow as a specialist of highly sensitive EPR techniques and their applications, acquire new knowledge of spins in biochemical systems and reach scientific maturity.

Keywords: electron paramagnetic resonance,magnetic resonance,high sensitivity,superconducting microresonators,cryogenic amplifiers,cryoprobeheads,rna binding proteins,magnetotactic bacteria,spin labels
The Semi-paracrystalline Organization in Polymers: Towards Stable Organic Solar Cells (PARACRYST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999000.0
EU funding (EUR): 1999000.0
Participants: 1
Project status: SIGNED

Most advanced semiconducting polymers do not seem to fit in the traditional structural clasification of polymers, which labels polymers as amorphous, semicrystalline or paracrystalline. In fact, a single semiconducting polymer can be interchangeably identified as amorphous, semicrystalline or paracrystalline depending on the characterization method used. Given the interlink between microstructure and optoelectronic properties in organic semiconductors, this vagueness has far-reaching consequences on the optimization of organic electronic devices, e.g. contributing, in the case of organic solar cells, to the current lack of solutions for their severe instability issues. The vision of paracryst is to fundamentally re-think the basic structural principles of polymeric semiconductors to finally decipher their solid-state microstructure. To achieve so, paracryst will use, and build upon the new concept of semi-paracrystallinity, i.e. the fourth structural model for polymers recently introduced by the applicant. The new semi-paracrystalline model puts in our hands a new “toolkit” that will be here directed to i) rationalize the so far elusive microstructure of semiconducting polymers, to ii) deliver more-precise structure-properties relationships for these materials, and iii) to induce major improvements in devices, starting with increasing the stability of organic solar cells. Gaining insight into a newly discovered semi-paracrystallinity, paracryst will reshape the very foundations of the physics of polymers. Moreover, it will induce a paradigm shift in how structure-function relationships are delineated in semiconducting polymers, impacting the whole organic electronics arena, from bioelectronics to neuromorphic computing to wearable electronics. But specifically, as proof of feasibility, paracryst will employ the semi-paracrystalline model to find once and for all efficient solutions to the degradation issue that is hampering the scaling-up of organic photovoltaics.

Keywords: semiconducting polymers,organic solar cells,organic semiconductors
Formation, Clustering, and Atmospheric Impact of Clusterable Organic Compounds (AtmosCOC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1496886.0
EU funding (EUR): 1496886.0
Participants: 1
Project status: SIGNED

Atmospheric aerosol particles have a critical impact on Earth’s radiative balance and human health. Oxygenated organic molecules play an important role in the formation and growth of aerosol particles. To contribute to initial steps of particle formation, a compound must either condense from the gas to the particle phase or undergo cluster-phase proton-transfer or other chemical reaction. I define a clusterable organic compound (COC) to be an oxygenated organic molecule which can participate stable cluster formation under atmospheric conditions. Due to the limited knowledge of the formation, structures, and properties of COCs, the exact mechanisms for the formation of aerosol particles remain puzzling. My vision to bridge this long-lasting knowledge gap is to implement a unique computational approach to tackle bottlenecks in studies of complex reaction mechanisms, to combine a versatile suite of quantum chemical methods to accurately investigate cluster formation and properties, and to combine the best qualities of mass spectrometry and matrix isolated vibrational spectroscopy to solve structures directly from the reaction chamber. The scientific objectives are to 1) solve the role of dimerization-initiated autoxidation mechanism in COC formation, 2) develop an instrumentation capable to reveal molecular structures and properties of COCs, 3) determine the formation mechanisms and rates of COC containing particles, and 4) estimate the atmospheric impact of newly formed COC containing particles. This project will establish the molecular-level foundation for future atmospheric research by solving how COCs form, what is their contribution to particle formation and properties, and what is their impact for our climate. This research results highly accurate reaction kinetics and cluster thermodynamics parameters for atmospheric models, which are crucial to constrain the large uncertainty in climate predictions caused by small aerosol particles.

Keywords: aerosols,reaction mechanisms,computational chemistry
Promoting social INNovation to renew multi-level and cross sector WATER governance (InnWater)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: France,Italy,Spain,Sweden,Hungary,United Kingdom
Call: Water governance, economic and financial sustainability of water systems (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2834847.5
EU funding (EUR): 2834847.5
Participants: 13
Project status: SIGNED

Over the last decades water governance has drastically evolved, progressively moving from a resource management silo approach to the Integrated Water Resources Management. The validation of innovative and cross sector governance is the forthcoming step to face the multi-dimensions societal challenges such as the climate change impact, population growth at the global scale and ensure a safe cross-sectorial water access and uses at the local scale. The next chapter of water governance still needs to be framed with the clear challenge of involving equally all the stakeholders including the citizen to allow transparency, inclusiveness, and accountability. The governance is foreseen as one major lever to support and orientate water policy and sectoral policies impacting the water sector. Water Energy Food Ecosystem (WEFE) nexus needs to be valued to embrace all the water uses in a sustainable manner across generations. The main objective of InnWater (Promoting social INNovation to renew multi-level and cross sector WATER governance) is to provide a set of digital tools and services (that will be gathered in InnWater Governance Platform) to support tailored multi-level and cross-sector water governance, associated with economic and financial mechanisms to support EU green deal transition while ensuring water systems sustainability. The InnWater project will deliver a governance assessment matrix, quintuple helix and citizen (trust) engagement framework, WEFE Nexus economic and resources allocation simulation including household water tariff and environmental costs, a self-sustaining governance community composed of 5 pilot sites in FR, UK, HU, SP, IT addressing different water challenges, a set of raising awareness and training tools, the identification of replication opportunities in at least 14 EU basins and a set of policy, regulation and economic recommendations to support EU policy implementation and new orientations.
Multi-dimensional mapping of lineage specific transcription factors through time and space (GRADMAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Here I propose an ambitious project designed to explore an exciting new hypothesis: TFs are non-randomly spatially organised within the cell nucleus, forming radial gradients that likely play an important role in regulating gene expression. This idea was born from one of the intriguing discoveries revealed by Genomic loci Positioning by Sequencing (GPSeq), a technique developed in the host lab, that the binding motifs of the majority of human transcription factors (TFs) seem to form radial density gradients, with some TF binding motifs being more abundant towards the nuclear periphery, whilst others more abundant in the centre. Furthermore, preliminary analysis showed that the predicted binding motifs of master regulator TFs specifying lymphoid vs myeloid lineages form opposing radial gradients, suggesting that this mode of transcriptional regulation is critical for cell fate specification. In this project, I will differentiate hematopoietic stem cell (HSC) into opposing lineages (lymphoid/myeloid) and perform TF CUT&RUN to assay TF occupancy and chromatin landscape, coupled with GPSeq to assay the radial arrangement of chromatin in these lineages. The intersection of these two genome-wide datasets will provide the first ever map of the occupancy of lineage specific transcription factors through differentiation time and nuclear space with respect to radiality. In parallel I will generate additional omics datasets in these cell populations to assay chromatin accessibility, transcription and chromatin interactions to build a comprehensive, multi-dimensional genomic atlas in which the spatial arrangement of TFs can be linked with gene expression dynamics. Crucially, no other study has thus far addressed this novel hypothesis; my work will provide significant advancements in understanding the interplay of genome architecture with transcriptional regulation and cell-fate specification.

Keywords: genome architecture 3d genome chromatin transcription factors gene expression radial nuclear organization lineage specification differentiation genome wide analysis
Toxicity of dolutegravir and evaluation of doravirine for alternative 1st line antiretroviral treatment in people living with HIV (ELDORADO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,Thailand,Cameroon,Mozambique,Côte d'Ivoire,United Kingdom,Brazil
Call: Developing novel, innovative HIV therapeutics for reducing the disease burden of HIV in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 5164865.0
EU funding (EUR): 5164865.0
Participants: 11
Project status: SIGNED

The integrase inhibitors dolutegravir (DTG) is recommended by the World Health Organization (WHO) for 1st line antiretroviral therapy (ART) in people living with HIV (PLHIV) since 2018. Despite its high virologic efficacy, there is growing evidence showing massive weight gain and high incidence of metabolic disorders (obesity, type 2 diabetes) and hypertension under DTG, notably among women from sub-Saharan Africa (SSA) women, along with mental health and quality of life issues. The non-nucleoside reverse transcriptase inhibitor doravirine (DOR) is a potent novel ART, recommended in European and North-American guidelines, but not used so far in Southern countries despite interesting virological, safety and resistance profiles. In this context, the ELDORADO project will generate high-quality data on DTG-based ART toxicity and evaluate DOR as an alternative for 1st-line HIV-1 treatment in order to support national and international policymakers in updating national and international guidelines and practices aimed to improve patient outcomes and reduce disease burden of HIV in sub-Saharan Africa and worldwide. The project includes i) a randomized clinical trial assessing the non-inferiority of DOR-based ART as compared to DTG-based ART in terms of virologic efficacy, and its superiority in terms of key safety endpoints (obesity, diabetes, hypertension) in 610 PLHIV from diverse ethnic backgrounds across in SSA (Cameroon, Côte d’Ivoire, Mozambique), Brazil, Thailand, and France, ii) innovative assessments of organ lesions, iii) assessments of mental health and quality of life, iv) health impact and economics modelling based on the trial results as well as that of other trials (NAMSAL) and cohorts (IeDEA West Africa and Brazil). The project will also prioritize capacity building for junior investigators and community advisory board. The ELDORADO trial will be confounded in non-SSA countries by the ANRS|MIE (trial sponsor) and MSD, and benefits from support from the WHO.

Keywords: hiv 1,art naive,doravirine,dolutegravir,non inferiority,safety,
Decentralised Ammonia production from Renewable Energy utilising novel sorption-enhanced plasma-catalytic Power-to-X technology (DARE2X)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Denmark,Spain,Sweden,Slovenia,United Kingdom
Call: Next generation of renewable energy technologies (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2380800.0
EU funding (EUR): 2380800.0
Participants: 6
Project status: SIGNED

The DARE2X project is proposing a disruptive approach to decarbonising ammonia (NH3) production: development of sorption-enhanced plasma-catalytic synthesis. NH3 is the chemical produced in the second highest quantities globally and is responsible for 1.8% of global CO2 emissions. Furthermore, its demand is expected to increase drastically in the coming decade through its huge promise as a green fuel. As a result, decarbonisation of NH3 production is an essential goal for decarbonisation of the EU economy by 2050. The timing is vital in starting the push for future production technologies for green NH3, to meet the expected increase in demand. The main challenges for realising European green NH3 production is to transition away from fossil fuel-based, centralised Haber-Bosch facilities, to decentralised, dynamic systems that can be coupled directly to renewable electricity generators at or near the point of use. This does, however, require significant developments. DARE2X will overcome these barriers through the following game-changing solutions: (i) reactors utilising non-thermal plasma to drive NH3 synthesis; (ii) novel, more active catalysts using low-CRM materials, iii) stable and efficient NH3 sorption materials for in-situ NH3 separation. These innovations will be integrated into a single sorption-enhanced plasma-catalytic device that will be validated at TRL4. The economic, environmental and social feasibility will be assessed through LCA, LCC and a social acceptance study. To meet these objectives, DARE2X combines world-leading research institutions and innovative and R&D-performing SMEs specialised in renewable technologies, materials engineering, and technology demonstrations. The novel DARE2X approach has the potential to make decentralised production of green NH3 cost-competitive, providing European self-sufficiency of this vital future fuel, and creating European scientific and innovation excellence that will spawn new companies and create jobs.

Keywords: renewable energy,green fuel,ammonia,power2x,sustainability,green transition,decarbonisation,decentralisation,energy independence,resiliance
EXperimental Aircraft for European Leadership In Aviation (EXAELIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Netherlands,France,Germany,Italy,Poland,Spain,Romania,Austria,Portugal,United Kingdom,Greece,Belgium,Sweden
Call: Towards a flying testbed for European leadership in aviation (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 16233889.5
EU funding (EUR): 16233889.5
Participants: 23
Project status: SIGNED

The objective of EXAELIA is to investigate and to answer the needs for novel flying testbeds for de-risking the development of disruptive future long-range aircraft, accelerating the reduction of all aviation emissions and its climate and environmental impacts in 2050. EXAELIA investigates, through advanced multi-disciplinary digital methods, the potential emissions reductions of long-range air traffic offered by promising blended wing body aircraft configurations and by hydrogen-powered tube-and-wing configurations, including their constituting radical new technologies. Critical uncertainties are identified, in particular those requiring flight validation for de-risking the future aircraft development. For those flight test requirements which go beyond the capabilities of existing assets, novel flying testbeds are developed towards their preliminary design and demonstrated to answer the flight validation needs, efficiently combining these needs in potentially costly large-scale modular flying testbeds. Roadmaps are prepared for the further development of the EXAELIA flying testbeds and their use in the development of the future long-range aircraft, entering into service before 2050 with a maximum contribution to reducing aviation impact and emissions (~49% of air transport system emissions in 2019 came from long range aircraft). Operational and business plans for these indispensable test bed assets are provided as well. The EXAELIA consortium consists of the major European research centres and academia in future aircraft conceptual design and analysis, flight testing, and flying testbed development, and 4 SMEs, all with a strong record in collaboration. An Advisory Board, including European aircraft and engine manufacturers and further industries will provide guidance to achieving the objective and to obtaining their support to the roadmaps. The total grant request of this 42-month action is 16 233 889 Euros.

Keywords: large scale modular flying testbed,long range aircraft,disruptive aircraft configurations,blended wing body,hydrogen,novel disruptive propulsion