Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Egr1 and Egr2 regulate opposite transcriptional programs in macrophages (MacrophageEGR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Macrophages play important roles in many aspects of immunity and therefore contribute to a diverse range of human inflammatory diseases, including atherosclerosis. The expression of macrophage genes is tightly controlled by regulatory DNA elements, such as enhancers. When macrophages are exposed to external stimuli, specific transcription factors affect enhancer activity, thereby impacting macrophage function in health and disease. I am investigating macrophage enhancer activation by interleukin-4 (IL-4). IL-4 is an important anti-inflammatory cytokine that suppresses macrophage activation and regulates immune responses during parasitic infections and allergies. I discovered that IL-4 activates the transcription factor Egr2 leading to specific IL-4-induced enhancer activation in macrophages. I surprisingly noticed that Egr1, while binding highly similar DNA motifs as Egr2, actually represses enhancer activity when macrophages are exposed to pro-inflammatory stimuli, indicating antagonistic effects of Egr1 and Egr2. By targeting transcriptional regulators, macrophages can be skewed to disease-favorable phenotypes. I here propose to investigate and target Egr1 and Egr2 in pro- and anti-inflammatory macrophage phenotypes in vitro and in disease. Aim 1: To elucidate the molecular mechanism resulting in differential outputs of Egr1 and Egr2 binding, I will study the transcription factor complexes in which Egr1/Egr2 function. Aim 2: To characterize the function of Egr1 and Egr2 in macrophages, I will study the effects of Egr1/Egr2 deletion in mouse and human macrophages. Aim 3: To study the roles of Egr1 and Egr2 in macrophage-driven diseases, I will delete Egr1/Egr2 in macrophages and assess the effect of deletion on atherosclerosis and endotoxemia. My proposed studies will reveal the role of macrophage Egr1 and Egr2 in disease and contribute to increased knowledge on how disease-associated signals regulate enhancer activity in disease-relevant cell types.

Keywords: macrophage,enhancers,signal dependent transcription factors
BRinging Artificial INTelligencE home for a better cAre of amyotrophic lateral sclerosis and multiple SclERosis (BRAINTEASER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Italy,Italy,Spain,Italy,Belgium,Serbia,Netherlands,Portugal
Call: Personalised early risk prediction, prevention and intervention based on Artificial Intelligence and Big Data technologies (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 5889190.0
EU funding (EUR): 5889190.0
Participants: 14
Project status: SIGNED

Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) are chronic diseases characterized by progressive or alternate impairment of neurological functions (motor, sensory, visual, cognitive). Patients have to manage alternated periods in hospital with care at home, experiencing a constant uncertainty regarding the timing of the disease acute phases and facing a considerable psychological and economic burden that also involves their caregivers. Clinicians, on the other hand, need tools able to support them in all the phases of the patient treatment, suggest personalized therapeutic decisions, indicate urgently needed interventions. Artificial Intelligence is the key to successfully satisfy these needs to: i) better describe disease mechanisms; ii) stratify patients according to their phenotype assessed all over the disease evolution; iii) predict disease progression in a probabilistic, time dependent fashion; iv) investigate the role of the environment; v) suggest interventions that can delay the progression of the disease. BRAINTEASER will integrate large clinical datasets with novel personal and environmental data collected using low-cost sensors and apps. Software and mobile apps will be designed embracing an agile and user-centred design approach, accounting for the technical, medical, psychological and societal needs of the specific users. BRAINTEASER will implement a system able to guarantee cybersecurity and data ownership to the patients; will provide quantitative evidence of benefits and effectiveness of using AI in health-care pathways implementing a proof-of-concept of its use in real clinical setting. Procedural requirements that support Software as Medical Device certification will be used involving clinicians and patients stakeholders and producing a set of recommendations for public health authorities. Results will be disseminated accordingly to an open science paradigm under the European Open Science Cloud initiative.

Keywords: open science,data fairness,personalized healthcare,decision support systems,quality healthcare at home,societal equality,risk detection,prevention,environmental exposure,wearables
5G-as-a-Service (5GaaS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,Belgium,Portugal,Portugal,Portugal
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2020-10-01
End date: 2023-12-31
Duration (months): 39.0
Total project cost (EUR): 3156325.0
EU funding (EUR): 2398127.5
Participants: 6
Project status: SIGNED

Even though the potential of 5G technology is well known, having it massively deployed and available to end-users is not an easy task. To unlock all of 5G’s use cases at scale, smaller radio equipment and antennas (Small Cells) must be deployed in a dense manner across closer to end users. However, there is a catch: it is currently very difficult for MNOs to be able to deploy this equipment at scale, within public spaces. Thus, a major obstacle must be overcome to ultimately unlock massive deployments and adoption: a common platform connecting both Infrastructure Owners (such as, but not limited to, Municipalities) and entities which are in dire need of having proper licensing and authorisation to install new or exploit readyto-be-used 5G equipment, easing the process for site acquisition, asset and network management, in the most transparent and simple way. 5GaaS intends to develop and launch a new product in the form of a decentralised marketplace for the telecom ecosystem, under a new Joint Venture. This new platform is the culmination of three major components, two of them currently already available in the market : a centralised marketplace for site leasing and tenant management, from Ubiwhere, and dRAX, from Accelleran, an interoperable, standards-based and software-focused implementation of 5G networks. The other innovative component will come out of H2020 5GCity project, to which 5GaaS partners have collaboratively contributed to by building an automated 5G network slicing engine for Neutral Hosts. 5GaaS expands these layers, implementing a decentralised marketplace connecting the whole 5G value-chain of stakeholders such as MNOs, site owners, system integrators and hardware and software vendors, using blockchain technology. During the project, the consortium will focus on pilot activities to showcase the benefits and capabilities of said platform, having it deployed across a total of 25 sites, in 5 different European cities.

Keywords: telco,network slicing,neutral hosting,edge computing,blockchain,smart contracts
A new class of powerful materials for electrochemical energy storage: Lithium-rich oxyfluorides with cubic dense packing (LiRichFCC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Slovenia,France,Denmark
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 4114753.75
EU funding (EUR): 4114753.5
Participants: 5
Project status: CLOSED

The LiRichFCC project will explore an entirely new class of materials for electrochemical energy storage termed “Li-rich FCC” comprising a very high concentration of lithium in a cubic dense packed structure (FCC). The process by which energy is stored in these materials constitutes a paradigm change in the design of battery materials and involves unexpected and surprisingly effective mechanisms: instead of storing lithium ions by intercalation into a stable host, lithium ions are populating and vacating lattice sites of the material itself. This new principle allows for unprecedented energy and power density compared to other battery materials and may revolutionize the use of batteries in applications involving a need for supplying large amounts of energy and power from small spaces. Li-rich FCC materials have just been discovered by one of the partners of the consortium, and the possible chemical compositions, properties, and charge storage principle associated with this new materials class are far from being understood. Thus, it is the aim of the project to explore and optimize possible compositions, synthesis methods, structural properties and dynamics of Li-rich FCC materials through an interdisciplinary approach involving predictive computational work, advanced chemical synthesis and high-end characterization. An important focus of the project will further be to evaluate the use of these materials for electrical energy storage and to identify potential other uses for Li-rich FCC materials that cannot be foreseen today. Due to the inherent paradigm change and the high promise Li-rich FCC materials hold both in regards to fundamental science as well as to battery applications, LiRichFCC fulfils all the preconditions of the call. The project is based on the long-term vision to develop a novel class of materials into practical use, involving foundational aspects in S&T with breakthrough character, high novelty and risk, and a broad, interdisciplinary approach.

Keywords: lithium ion batteries,disordered materials,oxyfluorides
In-situ second harmonic generation for emergent electronics in transition-metal oxides (INSEETO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 2498714.0
EU funding (EUR): 2498714.0
Participants: 1
Project status: CLOSED

Since transition-metal oxides heterostructures can be grown by pulsed laser deposition (PLD) with semiconductor-like accuracy, fascinating phases and functionalities derived from their spin-charge correlations have been discovered. So far, reflection high-energy electron diffraction is the only widely established technique for monitoring the structure and homogeneity of multilayers in-situ, while they are growing, and provide direct feedback information on how to optimise the growth process. With our proposal we will introduce second harmonic generation (SHG) as new in-situ technique that allows us to track spin-and charge-related phenomena such as ferroelectricity, (anti-) ferromagnetism, insulator-metal transitions, domain coupling effects or interface states in a non-invasive way throughout the deposition process. With this we are pursuing two goals: first, to establish SHG as new in-situ characterization technique in PLD which monitors strong spin-charge correlation effects while they emerge during growth; second, to apply in-situ SHG for tailoring novel functionalities in exemplary chosen types of transition-metal-oxide heterostructures of great current interest. These model systems are (i) proper ferroelectrics tuned to high-k dielectric response and improper ferroelectrics whose behaviour is determined by the unusual nature of the polar state; (ii) compounds in which the interplay of strain and defects leads to novel and reversibly tuneable states of matter; (iii) heterostructures with functionalities originating from the interaction across interfaces. In-situ SHG as new, property-monitoring tool in PLD has an immense potential to uncover new states of matter and functionalities. We are convinced that this will play an essential role in the leap towards the next generation of functional oxide heterostructures.

Keywords: multiferroics,magnetoelectric effect,ferroelectrics,oxides,strain
Integrating Punching and Laser Coil Technology for Metal Manufacturing Industry (Efficoil)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 1717675.0
EU funding (EUR): 1202372.5
Participants: 1
Project status: CLOSED

PRODUTECH S.r.l. is an Italian company specialized in metal sheet working machines, which counts on more than 20 years' experience in innovative machines production. With continuous innovation efforts, PRODUTECH is a notable actor on the global market with 166 customers in Europe and 22 customers outside the EU (India, North America and Far East), thanks to a worldwide distribution network. EffiCOIL represents a key business opportunity following the successful Phase 1 execution of the SME Instrument.Industrial activities are responsible for more than one fourth of the total energy consumption in Europe. In particular, the metallurgical industry is responsible for about 20% of such energy expenditure, summing up to about 51Mtoe per year. In this context, metal forming machines are used in a wide range of discrete production areas, including white goods, steel furniture, lighting and electrical equipment, automotive, etc. However, at moment, no solutions are available in the market offering a complete integration of the metal forming process, including electric punching, fibre laser cutting and direct coil feeding. With EffiCOIL project, PRODUTECH will get ready for the market launch of a new machine for metal coil working, combining the flexibility of coil metal punching – process already patented by PRODUTECH - with the precision and speed of the coil fibre laser cutting - first brought to market by PRODUTECH. The integrated technology will result in a 52% reduction in energy consumption for metal sheet production, as well as 20-30% reduction in wasted metal sheet, with a decrease in Capex and Opex versus standard metal processing machinery. The expected profitability will be high (TIR~23%). For PRODUTECH, EffiCOIL market launch will allow an optimization of the business structure, increase market area and volume, as well as the brand consolidation.

Keywords: punching,nibbling,laser cutting,metal coil,machine tool,processing energy
Digital Technology Use and Teen Wellbeing in Context: An Ethnographic Investigation (TecWell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The project is a comparative study of adolescent digital literacy and digital media use, using a mixed qualitative approach with an emphasis on ethnography. The rapid increase in children’s engagement with digital technologies raises questions regarding their potential impact on wellbeing. However, the data currently available to us as to this impact are largely inconclusive. This is partially due to the fact that most studies rely on quantitative measures that offer little insight into the actual content consumed, or the contexts within which engagement with media takes place. The study addresses these limitations by introducing the use of ethnographic methods to investigate the broader relational contexts within which teens’ interaction with digital media takes shape. Specifically, it investigates the relationship between two factors found to potentially impact teen wellbeing while using digital media: digital literacy, and the manners in which digital media is integrated into family life. Differences in digital literacy and family integration patterns are examined across both gender and socioeconomic divides, as well as between children who mostly consume digital media, and those who also produce digital media artifacts and contents through active engagements in spaces such as Fabrication Labs or Makerspaces. By taking a qualitative, holistic and longitudinal approach, the study aims to identify mechanisms involved in facilitating a fruitful integration of digital media into children’s lives, and to generate data needed for the development of strategies and guidelines to aid teens, parents and educators promote digital media engagement in manners that would enhance teen wellbeing.

Keywords: medical anthropology,digital media,digital literacy,wellbeing,family
European Researachers' Night in Madrid 2014-2015 (MadridERN2014-2015)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 187925.0
EU funding (EUR): 175000.0
Participants: 1
Project status: CLOSED

Under the motto “Supporting researchers, supporting the progress in Europe”, the European Researchers’ Night in Madrid 2014-2015, highlights the importance of researchers’ work, its contribution to the progress and welfare of the European Society and the need of getting support by the citizens. A democratic and participative society requires the involvement of citizens in scientific and technological issues. Researchers from the cutting-edge research centres in Madrid Region will show their work, their knowledge, their interests, their personal profiles, hobbies and enthusiasm. They will share all this to the public in a playful and fun atmosphere. Students and children will also have the opportunity of meeting researchers and entrepreneurs, asking questions, debating and being an active part of the activities. All scientific disciplines will be represented. Gender balanced will be also taken into account. Different European corners will show the advantages of the transnational research. Marie Skłodowska-Curie fellows and researchers of EU-funded projects will share with the public about their experiences working and living in Madrid. Common actions will be performed together with another European Researchers’ Night in Europe and in Spain and also if appropriate in the same Region. Special activities on the occasion of the 10th anniversary of the European Researchers’ Night during 2015 will be performed.

Keywords: european researchers night,researcher,society,public recognition,research job,schools,citizens,entrepreuners,students
Living cell lasers: intracellular lasing induced by natural and polymeric microscopic resonators (LIVING LASERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Can a living cell be turned into a laser? By aiming to coalesce biological cells with laser light, the most versatile tool that modern photonics has developed, LIVING LASERS explores entirely new ways to develop fully biocompatible lasers. The ability of vitamins, bacteria and even living cells to generate laser light has been recently demonstrated by the supervisor of the project, Prof Malte Gather. However, these and other experiments with active biological gain media are so far limited by the rigid and synthetic nature of the optical resonators, an essential part of any laser device. Introducing lasing in living cells independent of external resonators necessitates a conceptual change of the laser design. This is realized by internalization of microscopic resonators that will transfer the optical feedback directly into the cell. It is the main goal of this interdisciplinary project, located at the interface between material sciences, laser physics, photonics and biology, to demonstrate autonomous single cell lasing. Consequently, LIVING LASERS can be expected to start a whole new field in biophotonics and will help to overcome the boundaries between living nature and nowadays highly artificial and harmful laser technologies.

Keywords: biocompatible laser,structural colour,natural resonator,polymer resonator,endocytosis