Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multifunctional Hybrid Platforms based on Colloidal Nanocrystals to Advance CO2 Conversion Studies (HY-CAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1420648.0
EU funding (EUR): 1420648.0
Participants: 1
Project status: CLOSED

In reimagining the world’s energy future, while researchers are seeking alternative ways to produce energy, our current dependence on fossil fuels requires us to capture and store the CO2 to prevent reaching unacceptable CO2 levels in the atmosphere. In this scenario, recycling CO2 by converting it into useful chemicals, such as fuels for transportation, represents an important research area as it will eventually lead to independence from fossil fuels and petroleum. While much progress has been made, this emerging field is challenged by huge technical and scientific questions. The intrinsic thermodynamic stability of the CO2 molecule, combined with slow multi-electron transfer kinetics, makes its reduction exceedingly energetically demanding. Hy-Cat aims to develop novel material platforms to investigate different chemical paths that promote electrochemical CO2 reduction and direct product selectivity. We will synthesize hybrid materials comprising atomically defined CO2 sorbents and nanocrystalline CO2 catalysts intimately bound in a single integrated system. Three different classes of hybrids, each characterized by one specific absorption/pre-activation mechanism, will allow to investigate the effect of each mechanism on the catalyst activity. A key component of the research will be to develop synthetic schemes to access these multifunctional systems with an unprecedented level of control across multiple lengthscales. This control and the intrinsic tunability of the chosen building blocks will allow us to methodically compare structure and activity, so to determine the design principles upon which better catalysts can be made. We will argue that this understanding is required to remove the main bottlenecks towards efficient and selective catalysts to convert CO2 into useful products, such hydrocarbons. Hy-Cat is highly multidisciplinary and its scientific outcome will positively impact several other research fields in chemistry, materials science and engineering.
STRENGTHENING THE SFAX UNIVERSITY EXPERTISE FOR DIAGNOSIS AND MANAGEMENT OF EPILEPTIC ENCEPHALOPATHIES (SEED)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Belgium,Tunisia,France,France
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-01-31
Duration (months): 40.0
Total project cost (EUR): 799916.25
EU funding (EUR): 799916.25
Participants: 4
Project status: CLOSED

Epileptic encephalopathies (EE) are heterogenous epilepsy syndromes associated with severe cognitive disturbance. EE vary in their onset age, seizure types, electroencephalographic patterns and etiologies. New molecular technologies increased the genetic diagnosis rate. Inline with EU orientations and Twinning requirements, the SEED project will provide Sfax University (SU), with capacity building in excellence and innovation for earlier clinical and genetic diagnosis of EE, thanks to collaboration with AMU and UA, two internationally leading organisations for the diagnosis of EE. Early clinical and genetic diagnosis allows early management, improves prognosis and reduces health costs. The SEED project will: 1) strengthen the medical and technological capacity towards innovative technologies of SU in the field of EE 2) allow access to scientific excellence at international level for members of the SU which will lead ultimately to a better integration into international networks in MENA and EU regions. The successful implementation of this strategy will rely on specific actions including: 1)enhancement of the existing and the creation of innovative scientific and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2)training young researchers from SU to become trainers; 3)creating an experts’network for EE management centred at SU; 4) increasing awareness among the patient’s families through targeted dissemination and communication activities and 5) developing a strategy to sustain network activity beyond the project deadline. Through the completion of these activities, and with the support of AMU and UA, SU will be able to significantly reduce networking gaps, to increase its ability to compete for international research funds and to link further with stakeholders. In addition, thanks the SEED project, SU will become the reference center for the clinic and genetic diagnosis of EE in the MENA region.

Keywords: epilepsy,epileptic encephalopathies,electroclinical syndromes,genetic epilepsy,bioinformatics
High-throughput in vivo studies on posttranscriptional regulatory mechanisms mediated by bacterial 3'-UTRs (ReguloBac-3UTR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1876778.0
EU funding (EUR): 1876778.0
Participants: 1
Project status: CLOSED

In eukaryotes, untranslated regions located at the 3′ end (3’UTRs) of messenger RNAs (mRNAs) have been proved to be key post-transcriptional regulatory elements controlling almost every single biological process. In contrast, in bacteria, most studies regarding post-transcriptional regulation have been mainly focused on specific non-coding RNAs and 5’UTRs, which often carry riboswitches or thermosensors. Remarkably, bacterial 3’UTRs have been largely disregarded and have not been considered as potential regulators. Recently, we found that a 3’UTR modulates biofilm formation in S. aureus through its interaction with the 5’UTR encoded in the same mRNA. This mechanism resembles eukaryotic mRNA circularization. Also, a 3’UTR that contributes to cellular homeostasis by promoting hilD mRNA turnover was recently shown in Salmonella. Although both studies are pioneering showing the potential of bacterial 3’UTRs as regulatory elements, many questions still remain to be answered. Are 3’UTRs roles conserved in bacterial species? Do 3’UTRs contain specific regulatory sequences or secondary RNA structures? Are transcriptional terminator sequences relevant for certain 3’UTRs? Are 3’UTRs specifically recognized by RNA-binding proteins? Might 3’UTRs be responsible for bacterial speciation? Might bacterial 3’UTRs be the ancestors of eukaryotic 3’UTR evolution? To achieve these questions, here we propose a high-throughput analysis based on the development of specialized dual-reporter libraries to identify in vivo functional 3’UTRs by fluorescence-activated cell sorting coupled to RNA sequencing. Also the pool of RNA-binding proteins associated to 3’UTRs will be identified by global MS2-tagging and mass spectrometry. Examples of 3’UTRs belonging to physiologically important genes will be selected to deeply study regulatory mechanisms at the molecular and single cell levels. We expect that this project will largely change the view of post-transcriptional regulation in bacteria.

Keywords: high throughput transcriptomics analysis,bacterial posttranscriptional regulation,rna mediated regulation,bacterial rna protein interactions
Unraveling the history of adaptation in an island model: Cape Verde Arabidopsis (CVI_ADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 1609375.0
EU funding (EUR): 1609375.0
Participants: 1
Project status: CLOSED

Islands have played a pivotal role in evolutionary theory since Darwin and Wallace. Due to their isolation, they represent natural laboratories, providing uncomplicated microcosms where fundamental principles of the evolutionary process can be revealed. One area where island systems can provide a crucial advance is in evolutionary genetics. Here, a primary goal is to reconstruct the mechanisms, mode and tempo of the evolutionary process by identifying specific adaptive functional variants and studying the historical dynamics of these in nature. However, even with recent advances in tools and technologies (e.g., affordable genome-wide sequencing, developments in genome manipulation), the complexity of most natural systems makes this a challenging task. The proposed research launches a program that employs a unique set of thale cress (Arabidopsis) samples from intriguing populations at the edge of the species range (Cape Verde Islands) to comprehensively characterize the adaptive process in a tractable and ecologically relevant island system. This collection represents the first population sample from this region, where a single individual was collected 30 years ago and has long been an enigma due to its remarkable phenotypic and genetic divergence. We will combine field monitoring, population genetic analyses, trait mapping, powerful new genome editing technology (CRISPR), and spatially explicit modeling to reconstruct the history of the adaptive process in exceptional detail. Moreover, synthesizing our results in the context of biological networks will provide the opportunity to decipher how epistasis and pleiotropy impacted adaptive trajectories. By applying the wealth of tools available in Arabidopsis thaliana to this intriguing natural population, we will uncover general principles of adaptation and produce a roadmap and toolkit for future research in diverse systems to predict outcomes of environmental fluctuations and longer-term changes.

Keywords: adaptation,population genetics,arabidopsis
Understanding The Role of the defects to Accomplish high Performance and Stable Two Dimensional Devices (TRAPS-2D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Taiwan, Province of China
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-12-31
Duration (months): 26.0
Total project cost (EUR): 165666.88
EU funding (EUR): 165666.88
Participants: 2
Project status: CLOSED

Dr. Marquez proposes a new approach to improve the performance of 2D materials: the defect-engineering. This approach aims to investigate the critical issue of defects implication on the 2D semiconductors operation to solve the low performance and to accomplish a future CMOS co-integration. Electrically activated interfaces, surface and oxide states have demonstrated not only to reduce the device performance but also making the device to behave in a determine operation. Surface defect have shown metal workfunction pinning and therefore formation of Schottky barriers at the contact-semiconductor interface. In addition, depending on the energy level these defect, they can contribute like donor or acceptor dopant or like generation-recombination (trap) centers. In this regard, the fabricated devices would operate differently, presenting n-type, ambipolar or p-type behavior and accumulation or inversion operation modes. Fast operating, normally-on or normally-of devices can be addressed controlling the defect implications. The understanding and control of these defect states and impurities in 2D semiconductor systems is an essential area of research, and the first step is to develop the metrology tools to accurately quantify defect densities and distributions gaining further insight into the possible origin of the defects states. “TRAPS-2D” is a proposal to systematical study of defect (trap) states implications on 2D materials. Its novelty resides in the control of these defects to force the fabricated devices to operate in a specific mode and therefore control their performance. Additionally, the proposal holds an important technological transfer aspect considering the co-integration of these 2D materials in the standard CMOS processes to open the doors to ultimate commercial electronic applications.

Keywords: cmos,transistors,2d materials,tmds,mos2,semiconductor reliability,electrical characterization
TransAfrican Network Development (TANDEM)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Uruguay,France,France,France,Netherlands,Ghana,United Kingdom,United Kingdom
Call: e-Infrastructure policy development and international cooperation (H2020-INFRASUPP-2014-2, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 1217982.5
EU funding (EUR): 1217982.5
Participants: 9
Project status: CLOSED

The TANDEM project aims to create favourable conditions for WACREN (West and Central African Research and Education Network) to be able to participate in the forthcoming AfricaConnect project extension and to draw maximum benefit from it, and thereby to ensure WACREN’s integration into the global Research and Education networking community. TANDEM long-term goal is to make it possible for researchers and academics to contribute with their peers around the world to the socio-economic development of the West and Central African Region. To this end, TANDEM is structured around three objectives: 1. Enhance the dialogue between WACREN and policy makers, international donors and regulating authorities, in order to promote connectivity and obtain political and financial support; 2. Enhance the dialogue between WACREN, end users, national research and education networks (NRENs) and research and tertiary education institutes, in order to identify the global e-infrastructure services expected by the end users; 3. Build a permanent stakeholder dialogue by creating favourable conditions for the implementation of three main communities: the “policy makers, donors and regulating authorities” community; the NRENs community; the “end users” community. TANDEM provides for the implementation of a virtual collaboration platform in order to support the continuity of communities beyond the end of the project, and to enable monitoring of the e-infrastructure services. In order to respond to the growing demand from African research communities, TANDEM is focused on three key research thematic topics: health, food security, and environment; and on the specific needs of these areas. The consortium was carefully selected to provide a balanced mix of research and e-infrastructure organisations, with diverse experiences in academic issues, research and innovation management. The consortium also brings consolidated experience in implementing and managing large research and education networks

Keywords: e infrastructures,rren,nren,western and central africa,communication networks,africaconnect,geant,alice,community
Business Model for Orbital Maneuvering kit (BMOM)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain,Spain,France
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-05-01
End date: 2022-04-30
Duration (months): 12.0
Total project cost (EUR): 130000.0
EU funding (EUR): 100000.0
Participants: 3
Project status: CLOSED

An ElectroDynamic Tether (EDT) is a long conductor, typically a tape of aluminum, attached to a spacecraft that carries an electric current and exchanges momentum with the Earth magnetosphere. In particular, the interaction between the current and the Earth magnetic field generates a Lorentz drag force on the tape that deorbits the spacecraft without using propellant. The FET project with acronym E.T.PACK is developing a Deorbit Kit (DK) that will be bolt-on to satellites and activated at the end-of-life for post mission disposal. The goal of BMOM is making a business model for the DK in order to turn the flagship result of E.T.PACK into a genuine innovation with a disruptive socio-economic impact in the space sector while increasing the competitiveness of the European space industry. Besides activities on market analysis and competitiveness assessments, BMOM’s dissemination plan includes meetings with potential investors, customers, and public bodies in order to create the conditions to accelerate the development and the future commercialization of two concrete products: the DK and the EDT mission analysis software BETsMA v2.0. In particular, BMOM will: (i) perform a market analysis for the DK and BETsMA, (ii) define the most important use cases, (iii) address the industrial needs and cost to reach a commercial product, (iv) validate the DK use cases with respect to competitors, and (v) provide financial indicators of the identified business for the DK and BETsMA. These activities match with the expertise of BMOM’s consortium that includes a space product developer (SENER AE), an international consultant with deep knowledge on the space market (Euroconsult), and an academic partner with the expertise and know-how on EDTs (UC3M). BMOM has been designed to be the bridge between E.T.PACK, which will end by 2022 with a DK with TRL equal to 4, and a follow-up 2-year project that may end with the in-orbit demonstration of the DK by 2024.

Keywords: electrodynamic tether,de orbit kit,propellant less,business model,space debris
Software Platform for Multiscale Modelling of Reactive Materials and Processes (ReaxPro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Iceland,Italy,Germany,Germany,Slovenia,Netherlands,Netherlands,United Kingdom
Call: Accelerating the uptake of materials modelling software (IA) (H2020-NMBP-TO-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-08-31
Duration (months): 56.0
Total project cost (EUR): 4712043.75
EU funding (EUR): 4114410.75
Participants: 10
Project status: SIGNED

Reactive process design has largely been based on trial-and-error experimentation and similarly, reactor design has utilised empirical kinetics (data-based models). On the other hand, physics-based modelling approaches are emerging as highly promising in the development of new catalytic materials and reactive processes, and it would be desirable to be able to use high-fidelity, first-principles-based reactor scale simulations for process design. Multi-equation models are steadily gaining ground in the chemical reaction engineering community, combining mature tools at each scale, from the molecular up to the reactor. However, such efforts are currently restricted to academia; a commercial modelling suite and software platform, accessible to the generalist user, is lacking. To address this challenge, ReaxPro has identified a set of academic software tools (EON, Zacros, CatalyticFOAM) which will be upscaled into easy-to-learn, user friendly, interoperable software that is supported and well documented. These tools will be further integrated with commercial software (ADF Modeling Suite) into an industry-ready solution for catalytic material and process design. The ReaxPro Software platform and associated services will be made available via the European Materials Modelling Marketplace through the consortium's partnership with ongoing EU projects MARKETPLACE and VIMMP. To fully reach the target technology readiness level of 7, ReaxPro has partnered with translators and industry for validation and demonstration in pilot- and industrial-scale user cases. As a result of the proposed activities, academia and industry will have at their disposal an integrated, interoperable, customisable and modular modelling platform, enabling users to gain unique fundamental insight on reactive processes, but also a ready-to-use tool for the design of cost-efficient, environmentally friendly and sustainable processes, delivering measurable impact on the entire EU economy.

Keywords: multi equation material and process modelling,heterogeneous catalyst design and optimisation,data and model repository,marketplace,interoperability,software upscaling and industrial uptake