Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
De novo design of Lanthanide coiled coils for asymmetric catalysis (ChiralCatLnCoils)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Herein, we propose to design de novo (“from scratch”), a new class of lanthanide coiled coils (LCC) for chiral catalysis in water. The attractive features of Lnn+ complexes (strong and hard Lewis acidity, high coordination numbers and rapid ligand-exchange kinetics), will for the first time be coupled with de novo designed coiled coils, which offer the advantages of the protein ligand in metalloenzymes, for applications in catalysis.The resulting novel LCCs will exploit the peptide fold, chirality and second sphere residues, in order to perform exquisite chiral catalysis in water. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology. The complementary expertise of Dr Anbu (bioinorganic catalysis) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full catalytic potential of LCCs, and will, in conjunction with two planned short secondments, provide Dr Anbu with new and cutting-edge research training.

Keywords: bioinorganic chemistry,peptide design,lanthanides,catalysis
Automated e-buses Lithium Ion Battery Early Warning and Fire Suppression System (LiionFire)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Sweden
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2019-07-31
Duration (months): 18.0
Total project cost (EUR): 1447427.5
EU funding (EUR): 1013199.25
Participants: 1
Project status: CLOSED

Transport systems contribute to about 23% of the EU's and 16% of global total carbon dioxide emission but at the same time it is the main source of air pollution in cities. Widely accepted solution to that challenge is the usage of electric and hybrid electric city bus technology. The largest number of these buses is currently, and will in the foreseen future, use Lithium ion. (Li-ion) batteries pose a significant fire and explosion risks, as well as an exceptionally catastrophic threat of injury, death and loss of property. Thus, growth of the electric bus industry has accelerated the demand for e-bus fire suppression technologies. Current technologies do not fully meet customer needs as they do not offer automatic and integrated solution of early fire detection, system cooling and fire suppression. LiionFire, as an innovative product, seeks to address this gap. Dafo Brand AB is a leading fire protection system provider with over 30 years of experience in manufacturing, supplying and training services for a plethora of industries. The goal of this project is to validate, demonstrate and commercialize a highly innovative fire protection system for e-buses. It offers an early fire warning system, spot cooling to prevent thermal runaway and finally localize and suppress fires. Primary target users for LiionFire are city e-buses manufacturers, including our existing customers: Volvo, Iveco, Scania, Yutong and MAN. In the product commercialisation we will rely on the existing network of customers, OEMs and the existing worldwide distributors. Projected sales figures in five-year cumulative income are reaching 70MEUR. In the first business year we are planning to hire more than 20 employees while ending with more than 65 in the fifth year. The EU-added value will be expressed through safer electrification of transport, decarbonisation and maintaining global competitiveness of the European economy.

Keywords: fire protection systems,li ion batteries,electric buses,electric vehicle fires
An innovative system capable of monitoring and removing heavy metals, phenolic compounds and biological pollutants in drinking water (SWaT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The needs in the water drinking water quality monitoring and treatment are related to: 1) Detection and quantification of chemical contaminants as well as to detect and eliminate biological contaminants ensuring the water quality required by legislation 2) Implementation of drinking water systems to detect and kill Legionella. 3) Reduction of the use of chemical additives for environmental purpose and quality water purpose. SWaT(Safe Water Treatment System) will be a system for sanitizing water that will combine innovative technologies based on nanomaterials and new screen-printed bio(sensors), and a sustainable water ultraviolet treatment system, creating an unique equipment for on-site monitoring and removing of chemical pollutants (Cadmium, lead, arsenic and mercury, and Bisphenol A) and biological (Legionella and amoebae) pollutants in water. The novelty of SWaT lays in its capacity to monitor in real time pollutants (15 minutes vs. 1 day of current technologies), and moreover to remove these contaminants by a UV ray in combination with a filtering nanostructure (below the regulation threshold limits (1μg/l)) in an environmentally friendly way (avoiding the emission of 866.629 gCO2e for each kilogram of chemical additive reduced). Additionally SWaT will be the first technology monitoring of Amoebae, which have been recently demonstrated to host Legionella, and increased its resistance to the sanitation treatment. Currently SWaT have reached a TRL 6 in the scale from idea to application. To reach the TRL 9 will carry out a Feasibility Study in which we will analyse its technical feasibility, the commercial feasibility and the financial feasibility. SWaT will address the EU challenges of reduce the Legionella diseases in hotels and hospitals, and improving the water quality by reducing the chlorite in water. Our target users are the hospitals and hotels requiring water monitoring and treatment technologies to ensure healthy water to patients and hostages.

Keywords: water treatment,chemical pollutants,biological pollutants,heavy metals,phenolic compounds,legionella,amoebae,chemical additives,environmental friendly,detection limits,efficiency
Competitive and CO2 Free Energy from Osmotic Power – Large Scale Deployment (SaltPower)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-05-01
End date: 2023-04-30
Duration (months): 36.0
Total project cost (EUR): 3444371.25
EU funding (EUR): 2411059.88
Participants: 1
Project status: SIGNED

The Osmotic Power Unit (OPU) is an innovation that can produce competitive, clean and environmentally friendly energy using the natural force of osmosis: A difference in salt concentration in water streams creates a pressure gradient, which can be harnessed for power generation. The SaltPower OPUs are delivered in containerized modules and generate non-fluctuating baseload power for own consumption or the power grid. Today SaltPower delivers a mobile 20 kW the OPU and will be able to upscale and deliver a 100 kW unit as a direct result of this EIC project. Already now, when moving out of the demonstration phase, salt power costs only half of state-of-the-art wind power. The electricity generated from our OPU unit will cost 0.021 €/kWh, or approx. only 20% of current average EU market price of 0.10 €/kWh. As production scales and membranes are developed even further, the price of electricity from SaltPowers OPU can be as low as 0.01 €/kWh, equivalent to 1/10th of the EU average. The OPU is built into 40’ containers and can be assembled by a skilled and semi-skilled workforce in a pace where SaltPower can grow and learn while the technology and business mature. We have demonstrated the technology and the low LCOE in real life through a 20 kW demonstration plant (D20) operated at the Nouryon (formerly AkzoNobel) salt production plant in Denmark in 2018/19. This applied project will upscale the technology to the SaltPower J100 that has the innovativeness for market disruption, not only on the first niche market, but in several markets later. The European market holds the potential for several thousand plants from SaltPower, who targets a turnover of €41m by 2025 by focusing on the market segment with easiest implementation and biggest value to customers: Salt producers.

Keywords: salt power,pressure retarded osmosis,membrane
Tolerogenic immunotherapy with peptide-pulsed dendritic cells in rheumatoid arthritis (TIPPDECRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-05
End date: 2018-05-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

After obtaining my PhD at the University of Utrecht in the Netherlands, I moved to San Diego for a 1-year postdoc at the La Jolla Institute for Allergy and Immunology. I now propose to move to Newcastle University in the United Kingdom to undertake a project on a new cell-based therapy for rheumatoid arthritis (RA), a destructive joint disease. This project is important since this new therapy could provide long-term benefit to RA patients. So far I have conducted all my work in mouse models. This project will enable me to acquire new expertise in human immunology and translational research. The host team at Newcastle University has developed a new immunotherapy for RA with tolerogenic dendritic cells (tolDC). These tolDC have been designed to switch-off destructive immune responses in the joint via the induction of regulatory T cells. The team has completed a phase I trial with tolDC in RA, and has found that the therapy is safe. However, in order to conduct a phase II efficacy trial, one crucial aspect of tolDC therapy must be improved: loading of tolDC with a relevant (auto)antigen so that they can induce antigen-specific regulatory T cells in the joint. However, selecting a suitable auto-antigen has been problematic. I propose that heat shock proteins (HSPs) are suitable antigens for loading of tolDC. HSPs are ubiquitously expressed in the rheumatoid synovium and pathogenic T-cell responses to these HSPs are found in RA patients. I hypothesise that by loading tolDC with exogenous synthetic peptides from HSPs, the pathogenic response can be suppressed through the induction of HSP-specific regulatory T cells. My project aims to i) establish a suitable HSP-peptide selection for tolDC-induced peptide-specific tolerance in RA patients and ii) test the therapeutic potential of HSP-peptide-loaded tolDC in a mouse arthritis model. A successful outcome of this work would form the basis of a new clinical trial with HSP-loaded tolDC in RA patients.

Keywords: tolerogenic dendritic cells,rheumatoid arthritis,antigen presentation,heat shock proteins
A novel cost-efficient bioreactor to accelerate growth of valuable plant roots for nutraceuticals, pharmaceuticals cosmetics (Rhizomia)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Belgium
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

From the 391,000 known species, 18,000 have documented medicinal effect and only 150 are industrially cultivated. Their active principles are extracted from wild or cultivated plants, but the production of these compounds is not sufficient to meet the growing market demand. New sustainable production methods include in-vitro cultivation in bioreactors. However, the main limiting factor is the plant biomass growth rate (e.g. state of the art bubble column bioreactors only reach a doubling time of 20-30 days for ginseng roots). Existing bioreactors are therefore unable to produce at an economically viable level sufficient amounts of biomass and active molecules except for rare applications with very high added value (e.g. pharmaceuticals). The project develops a novel bioreactor technology enabling a 2x faster biomass growth and a 2-3x boost in active compound elicitation level. Root bioreactors have been so far designed by pharmaceutical engineers without cost considerations as they target high value application. Our team, coming from a food biotech background, has been able to design low-cost bioreactors compatible with high-volume production where costs can be divided by a factor of 10 to target lower value applications such as nutraceuticals. The project initially focuses on the development of a 30 ton/year pilot plant for ginseng roots, a market of 25,000 ton/year currently dominated by US and Asian producers. In addition, the technology has been validated for 29 other root varieties and has the potential to support in-vitro cultivation of any plant root, covering numerous applications in nutraceuticals, pharmaceuticals, cosmetics, fragrances, pest-control, phyto-protection and food additives, among others.

Keywords: bioreactor,hairy roots,in vitro cultivation,plants,nutraceuticals
Unobtrusive, continuous and quantitative assessment of Parkinson’s disease: hard evidence for optimal disease management with information technologies (PARK-IT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sense4Care S.L. (S4C) is high-tech SME constituted in Barcelona in 2013 as a spin-off of the Universitat Politècnica de Catalunya - BarcelonaTech (UPC) with a clear objective: taking to the market the results of several research projects. UPC itself holds 5% of the shares of the company, and the rest belongs to professors, researchers and investors. UPC was the Coordinator and main beneficiary of the FP7-ICT project called REMPARK1 project, and has legally transferred the exploitation rights of the project results to S4C, with the aim of commercialising a product that can dramatically improve the lives of Parkinson’s Disease (PD) sufferers. The main result from the FP7-REMPARK project is the kinetic monitor PARK-IT, which can be exploited as a standalone product. PARK-IT is a new gold-standard, continuous and quantitative monitoring medical device for assessing the status of Parkinson Disease patients. PARK-IT device, based in movement detection and complex algorithms, allows the doctors to precisely adjust the medication of PD patients, overcoming one of the main problems that PD patients face. It constitutes a disruptive innovation answering to an unmet need. The present innovation business project is therefore focused in taking this device to the market through a clear and innovative business model.

Keywords: parkinson s disease,inertial sensor,advanced algorithms,motor symptoms,movement sensor,waist,kinetic sensor,disease management,assessment monitor,healthcare,commercial viability,market
Post-Cellular Wireless Networks (POSTCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1876846.0
EU funding (EUR): 1876846.0
Participants: 1
Project status: CLOSED

POSTCELL aims at laying the foundation for future generations of wireless networks as they move past the reigning cell-centric paradigm and into the post-cellular era. This entails the definition of a new architecture for such networks and the characterization of the ensuing performance. For the future of wireless communications, the implications would be far-reaching. The growth of wireless traffic is relentless, and it is actually gaining new momentum on account of fresh mechanisms: smartphones, cloud computing, and machine-to-machine communication. As a result, the volume of wireless traffic is poised to increase to truly staggering levels and, to face this challenge, wireless networks need to enter a new stage. There is a fledging awareness that this challenge can only be fended off by a process of network massification, with two views about it. In the first view, densification is the only strategy through which dramatic improvements can be attained hereafter; this leads to a vision where base stations become tiny and exceedingly abundant. The second view, in turn, is built on the idea of dramatically scaling the number of colocated antennas per base station from the current handful to possibly hundreds. One of the seeds of POSTCELL is that, since neither form of massification can by itself resolve the challenge facing wireless systems, the two forms will have to end up coexisting. Reconciling these two forms of massification and enabling a truly phenomenal scaling calls for an entirely new architecture where cells and physical base stations become things of the past, replaced by dynamically defined virtual base stations, powerful caches, and the possibility of device clustering, among other leaps forward. The signal processing needs to shift away from base stations, which become deconstructed, so as to gather at new places. POSTCELL seeks to drive this transformation and to gauge the performance of post-cellular wireless networks.

Keywords: wireless,communications,information theory,communication theory,radio
FOR THE CIRCULAR ECONOMY OF TYRE DOMAIN: RECYCLING END OF LIFE TYRES INTO SECONDARY RAW MATERIALS FOR TYRES AND OTHER PRODUCT APPLICATIONS (BlackCycle)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Spain,Spain,Germany,Spain,Greece,Switzerland,France,France,France
Call: Raw materials innovation for the circular economy: sustainable processing, reuse, recycling and recovery schemes (H2020-SC5-2019-2, 2019)
Start date: 2020-05-01
End date: 2024-06-30
Duration (months): 50.0
Total project cost (EUR): 15859724.66
EU funding (EUR): 11919385.64
Participants: 14
Project status: SIGNED

The BlackCycle project has an upcycling ambition, targeting to create a circular economy of the end-of-life tyre (ELT) into technical applications like tyre industry by producing high technical second raw materials (SRMs) from ELTs. A key lever is to consider the circular economy of tyre domain: recycle ELT into new tyres. Known technologies in this domain are today limited and this new research project will have the ambition to pass their roadblocks, and deliver new technical raw materials relevant for tyre production or other technical products. This project will proactively integrate these new materials (SRMs) and validate that the progress in all the key tyre performances having environmental impacts is not slowed down. The BlackCycle project aims at creating, developing and optimising a full value chain, from ELT feedstock to SRMs, with no waste of resources in any part of the chain and a specific attention for the environmental impact. Eventually, close to 1 out of every 2 ELT will go through this new recovery process which will be the only virtuous cycle of this magnitude amongst all industrial sectors in the recovery of end of life products. In effectively implementing this change, the European tyre industry will be a world leader in a more sustainable tyre production. Indeed, the main product obtained at the end of the project would be a new tyre where many raw materials come from ELT. In particular, the carbon black, a material representing ~20% of tyre composition, will be fully obtained from oils extracted from waste tyres through the pyrolysis process. Furthermore, several chemical and plasticizers will also be obtained from pyrolytic oil refining. The final product would have a high added value from an environmental point of view, because more than 25% of the total weight would come from recycled ELT.

Keywords: tyre recycling