Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Combinatorial use of cannabidiol and the serine hydrolase inhibitor AKU-005 to enhance endocannabinoids for treatment of migraine (Migraine cannabinoid)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 454103.4
EU funding (EUR): 454103.4
Participants: 2
Project status: SIGNED

Migraine is a common multifaceted neurovascular disease. Traditional medications have limitations and even newer CGRP monoclonal antibodies only effectively treat 50% of patients. Instead of using highly addictive painkillers, such as opioids, there is a great need for alternative, effective and safe medications. Despite psychoactive side-effects of cannabis, its derivative compounds (cannabinoids) have emerged as a new class of analgesic and anti-migraine agents. Indeed, the frequency of migraine headaches decreases with medical marijuana. To avoid cannabis psychotropic effects, an alternative is to recruit the anti-nociceptive actions of endogenous cannabinoids (endocannabinoids). The two main endocannabinoids are 2-arachidonoylglycerol (2-AG) and anandamide (AEA). The anti-nociceptive efficiency of 2-AG and AEA is determined by their enzymatic synthesis, activity on receptors CB1 and CB2, and degradation by monoacylglycerol lipase (MAGL) and fatty acid hydrolase (FAAH), respectively. There is recent progress in the development of selective and potent MAGL and FAAH inhibitors, providing excellent starting points for enhancing endocannabinoid activity. A key point is that the enzymes are distinctly active in different migraine pain signaling areas. Therefore, we propose that at least a dual FAAH and MAGL inhibition would be ideal. We have shown that the serine hydrolases inhibitor AKU-005 potently reduces migraine-related nociceptive activation. Of further relevance, the combination of CB1/2 orthosteric delta-9-tetrahydrocannabinol (THC) and allosteric cannabidiol (CBD) agonists can reduce central and peripheral-induced light aversion in CGRP migraine models. Our hypothesis is that enhancement of endocannabinoids by the inhibitor AKU-005 in combination with CBD treatment could safely inhibit migraine-related pain pathways, representing an alternative, non-addictive therapeutic target to help bridge the therapeutic gap and reduce the significant burden in migraine.

Keywords: anandamide,2 arachidonoylglycerol,headache,cannabinoids
Radiative Corrections for Heavy Quark(-onium) Production in High-Energy Factorisation (RadCor4HEF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

At High Energy hadron colliders, the wide phase space for particle emissions can compensate the smallness of the strong-interaction coupling of Quantum Chromodynamics (QCD). At the LHC this effect is crucial for production of mesons containing charm and bottom quarks. At hadron collider with energy of 100 TeV, all Standard Model physics will be affected by these large corrections. RadCor4HEF's objective is to develop an efficient and robust method to match these phase-space corrections, provided by High-Energy Factorization (HEF) formalism with standard QCD computations in Collinear Factorization(CF). At present, this is not available. I aim at advancing the HEF including sub-leading corrections in the strong-interaction coupling within a new computational framework. I will apply it to study the production of (i) the eta_{c,b}-mesons in the LHCb kinematics, (ii) photoproduction of J/psi and Upsilon mesons (iii) hadroproduction of open heavy-flavour mesons. For all of these observables the theoretical uncertainties are larger than the experimental ones and we will change this. The matched CF+HEF framework solves the instability problems of standard CF computations for eta_{c,b}, J/psi and open heavy flavour meson production at the LHC energies. RadCor4HEF will contribute to our quest to understand the proton structure and to predict heavy-quark bound-state production, which are the most poorly understood parts of QCD. The science generated by RadCor4HEF will be disseminated via top-level publications, oral communications, outreach events and computing codes integrated in the EU Virtual Access "NLOAccess". Project activities will take place in the theory pole of IJCLab Orsay managed by CNRS, which gathers all the required expertise in the theory and phenomenology of QCD and particle physics. The exceptional environment part of Paris-Saclay U. will offer me an ideal training to develop my skills, to extend my research network and to become an independent researcher.

Keywords: quantum chomodynamics,radiative corrections,pertubation theory,high energy colliders,heavy quarks,heavy quarkonia,lhc,fcc,factorisation and resummation
Characterising the role of microbial behaviour and nutrient exchanges in coral symbioses (SymbioCues)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1999672.5
EU funding (EUR): 1999672.5
Participants: 1
Project status: SIGNED

Coral reefs are the most diverse marine ecosystems, but are currently threatened by anthropogenic stressors that disrupt the relationship between the coral host and its microbial symbionts (i.e., endosymbiotic microalgae and bacteria). While these symbionts are fundamental to coral health, corals do not generally transmit them to their offspring, who have to acquire them from the environment. Despite the critical roles of microbial symbionts for coral health, we still do not know how they find and colonise their coral hosts, which key compounds are exchanged between the various partners once in symbiosis, and to what extent bacterial symbionts contribute to coral growth. My previous research has revealed the importance of chemotaxis in other marine symbioses, a behaviour allowing microbes to find their host by homing in on the chemical cues it produces. Building on my previous research and preliminary data, I hypothesise that coral symbionts also use chemotaxis to find and colonise corals. Using a unique combination of cutting-edge approaches, this project aims to characterise the onset and functional consequences of coral-microbe symbioses. More specifically, it will: (1) identify the chemical cues underpinning the recruitment of coral symbionts, using analytical chemistry approaches and in situ chemotaxis assays that I previously developed; (2) determine how key bacterial symbionts colonise their coral host, through genetic engineering of the bacterial symbionts with live imaging and microscopy; (3) characterise the chemical exchanges between bacteria, microalgae, and their coral host, by combining co-culture assays, omics, and high-resolution secondary ion mass spectrometry. By deciphering the chemical language of coral symbiosis, this project will reveal biological processes at the foundation of coral health, a game changer in the current context of widespread reef degradation.

Keywords: corals,chemotaxis,symbiosis,nanosims,symbiont acquisition,metabolic exchanges
Justice-Oriented Strategies for Social Adaptive Risk Management (JUSTSAFE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Romania,Spain,France,Slovakia,Türkiye,United Kingdom,Germany,Hungary,Latvia,Netherlands,Belgium
Call: Demonstration of approaches by regions and local authorities focused on increasing climate resilience of the most vulnerable social groups (just climate resilience) (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 7862138.1
EU funding (EUR): 7491750.6
Participants: 25
Project status: SIGNED

JUSTSAFE project aims to design and implement just and inclusive strategies for enhancing climate resilience and digital transitions, prioritizing the most vulnerable and marginalized social groups such as the elderly, children, women and girls in all their diversity and individuals with disabilities who disproportionately suffer from climate change impacts. The project underscores the necessity of local authorities making direct investments that impact vulnerable communities significantly. A recent workshop, "Digitalization for Climate Action: Co-Creation, Collaboration and Just Transitions," highlighted the importance of co-creative digital activities for inclusive participation, activism's role in digital and climate spheres, the engagement of political actors in prioritizing climate measures, and the support for sustainable innovations in cities to prevent the exclusion of vulnerable groups. This project aligns with the EU Mission Adaptation to Climate Change, promoting a comprehensive approach to inclusive adaptation to climate change.

Keywords: vulnerable communities,just resilience,risk communication,capacity building
INTELLIGENT ENCAPSULATION AND SCREENING PLATFORM FOR PRECISION DELIVERY OF PROBIOTICS TO IMPROVE GUT HEALTH (iNSIGHT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Belgium,Italy,Lithuania
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3691038.75
EU funding (EUR): 3194343.75
Participants: 6
Project status: SIGNED

Over the past century, drastic lifestyle changes have caused disbalanced gut microbiota, which has been linked to various health conditions and noncommunicable diseases. Probiotics are a promising route for restoring a healthy gut microbiome, but their inherent sensitivity towards oxygen-, water-, heat and/or gastric acid greatly hampers their widespread application in disease prevention and treatment programs. iNSIGHT solves this longstanding challenge by realizing precision probiotics via a novel and disruptive microencapsulation approach. We set ourselves the goal to investigate and develop a tunable microcapsule formulation and scalable encapsulation process for the protection and targeted post-stomach delivery of sensitive probiotic formulations. Specifically, we will work on unique bi-gel-based microencapsulation formulations that are expected to provide unsurpassed protection to probiotics. To study the structural breakdown of capsules and thereby the controlled release of probiotics, we will develop and test a novel gut-on-a-chip microfluidic device. To obtain more in-depth knowledge as well as prepare for high-throughput screenings, we incorporate machine learning for i) automated investigation of digestion kinetics under personalizable conditions and ii) automated in-line identification, evaluation, and adjustment of microcapsule synthesis. As a proof of concept, we will leverage our encapsulation and screening platforms to protect a sensitive next-generation strain and make our precision probiotics formulation available to patients via personalized treatment of a patient cohort under pharmacy legislation. iNSIGHT forms the basis for protection and delivery of sensitive probiotic ingredients, and thereby contributes to the prevention, alleviation, and/or treatment of myriad health conditions related to unhealthy gut microbiota.

Keywords: microencapsulation,probiotics,targeted release,microfluidics,reinforced machine learning,in vitro digestion and fermentation,high throughput,patient cohort
Accelerated Additive Manufacturing: Digital Discovery of a New Process Generation (ExcelAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1484926.0
EU funding (EUR): 1484926.0
Participants: 1
Project status: SIGNED

Additive Manufacturing (AM) by Laser Powder Bed Fusion (LPBF) has the potential to revolutionize future product development, design and supply chains. Since the underlying multi-scale physics are not well understood, its potential can presently not be exploited. Sub-optimal process conditions lead to severe defects on different scales, rendering parts unsuitable for use. Critically, known regimes of stable processing go along with very low built rates, i.e., very high costs compared to other processes. This limits LPBF to selected high value applications such as medical devices but prohibits applications in mass production where it otherwise could allow for entirely new technologies. ExcelAM aims at the digital discovery of novel high-throughput process regimes in LPBF, to increase build rates by at least one order of magnitude. Computational modeling would be perfectly suited for this purpose since it allows to observe physics that are not accessible to measurement and to study novel process technologies that are not feasible with existing hardware. Unfortunately, existing computational tools are by far not powerful enough, given the complexity of LPBF. Therefore, ExcelAM will develop novel game-changing methodologies, grouped into two main classes: First, novel high-fidelity multi-physics models will be developed, capturing the complex multi-scale nature of LPBF. These are combined with cutting-edge high performance computing schemes, allowing for predictions on unprecedented time spans and system sizes. Second, novel data-based learning approaches will be developed to enrich the physical models with process data, while exploiting the manifold of existing data as effective as possible. Based on these cutting-edge tools, ExcelAM will push the limits of LPBF. Moreover, by making them publicly available, ExcelAM will help scientists and practitioners in the field of production engineering and beyond to face the technological challenges of the 21st century.

Keywords: metal additive manufacturing by laser powder bed fusion,physics based modeling and simulation,computational mechanics,coupled multi physics problems,high performance computing
Controlled Degradable Polymer Carriers for mRNA Vaccination: From Pathogens to Personalized Cancer Immunotherapy (PolymeRNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1999998.75
Participants: 1
Project status: SIGNED

The tragic outbreak of the COVID-19 pandemic stimulated research to go beyond common grounds and develop powerful vaccines against the SARS-CoV-2 virus. A new vaccine technology based on messenger RNA (mRNA) was translated into almost one billion patients and saved millions of lives. It addresses the needs of rapid, scalable and adaptable vaccine production. However, mRNAs require potent nanocarriers to prevent the RNA strands from extracellular degradation and enable their uptake into antigen-presenting cells. During urgent development, established lipid-based nanoparticles (LNPs) were used for mRNA encapsulation, yet, they provided limited long-term stability and required strict temperature storages, which prevented their distribution to locations with no cold storage options. Moreover, several patients experienced hard-to-control immunological adverse effects that were associated with some of the lipid components. In my ERC proposal, I therefore want to pioneer a novel and unprecedented macromolecular approach that will overcome these issues and introduce polymer-based and lipid-free, lyophilizable nanocarriers for intelligent mRNA delivery. I will generate self-immolative poly(carbonate)s with reductive decationizable features for controlled RNA complexation, as well as stimuli-responsive release and carrier depolymerization upon entry into antigen-presenting cells. Co-delivery of small molecule immune modulators will enable precise control over quality and quantity of the pursued humoral and cellular immune responses. Moreover, reversible core-crosslinking and surface conjugation with relevant targeting units will foster systemic in vivo applications towards immunization against infectious diseases and cancer. Elaborating multi-responsive macromolecular tools on an mRNA-binding polymer will become a groundbreaking asset for mRNA delivery, circumvent today’s still not overcome hurdles and enhance its access to and acceptance by the general public.

Keywords: mrna delivery biodegradable polymers immuno engineering stimuli responsive nano vaccine
Nonwage attributes, gender, and the future of work (MORETHANMONEY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Germany,Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1566010.0
EU funding (EUR): 1566010.0
Participants: 2
Project status: SIGNED

Digital technologies, the Covid crisis, rising incomes, and changing work attitudes all contribute to the recent increase in the importance of certain nonmonetary aspects of work - most prominently flexibility and work meaning. What does this mean for gender differences on the labor market and for the future of work? MORETHANMONEY will integrate flexibility and work meaning into the theory and empirics of family labor supply and retirement choices. In three subprojects, I will develop models that combine behavioral, labor and family economics, collect unique data sets that combine administrative, survey and experimental parts, and use structural and reduced-form estimation techniques. A) I will use models of collective labor supply and newly collected data to analyze the choice of hours worked, flexibility, and time spent with children at the family-level. Choosing flexibility may reduce wages and decision power and thus affect the distribution of family resources. A hidden cost of recent policies aimed at increasing flexibility may be that wages and bargaining power of women decrease. B) I will combine the labor economics (flexibility) with the behavioral (meaning of work) perspective and collect data on trade-offs between meaning, flexibility, and wages consistently in several countries. Choosing occupations and sectors with high meaning (like health and education) may restrict the flexibility choice and force women to reduce their labor supply. C) I will take the long-term perspective. While wages translate into retirement incomes, nonwage attributes do not, but they may cause an increase in labor supply. I will model and collect data on trade-offs between wages, hours worked, and nonwage attributes and estimate their effect on retirement decisions over the life cycle. This will greatly increase our understanding of the large differences in retirement incomes between men and women.

Keywords: flexibility work meaning work mission family economics collective labor supply gender wage gaps retirement gaps data collection hypothetical choice experiment administrative data
Decentralized Cryptographic Systems (DECRYPSYS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1998351.0
EU funding (EUR): 1998351.0
Participants: 1
Project status: SIGNED

Much of our digital infrastructure still relies on centralized systems, which are prone to failure and, more importantly, present appealing targets for criminals and other ill-intentioned parties. A successful attack on a centralized system can have huge repercussions in terms of loss of confidentiality, integrity and availability of data and services: alas, once private data leaks, it is impossible to “put it back” into the confidential domain. The fragility of centralized systems is one of the reasons that the interest in decentralized cryptographic systems (such as Secure Multiparty Computation, Blockchains, and Threshold Cryptography) has surged in recent years. Decentralized systems are more resilient against external and internal threats: even if some fractions of the parties are corrupt and misbehave, it is still possible to guarantee crucial security properties such as data privacy and correctness of outcomes. However, as these systems get deployed and used by citizens and institutions, it becomes evident that many of the assumptions made in the scientific literature do not match the reality in which such systems are used: as security proofs might no longer hold, this opens the door for potentially catastrophic security consequences. With this project I intend to take a step back and design cryptographic systems with solid theoretical foundations, with focus on ensuring that the abstract models in which cryptographic systems are designed and proven secure are a close match to the everchanging reality in which they get deployed, addressing e.g., the peculiar nature of decentralized systems and the challenges presented by advances in quantum computing. A successful outcome of the project will lead to novel, more efficient, and more secure cryptographic protocols for complex tasks. All the results of the projects will be made publicly available to help companies and society secure the critical infrastructures underlying their digital interactions.

Keywords: cryptographic protocols,secure multiparty computation,zero knowledge proofs,threshold cryptography