Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Personalised maxillofacial bone regeneration (MAXIBONE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Norway,Switzerland,Norway,France,France,France,France,Denmark
Call: Clinical research on regenerative medicine (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 5975915.0
EU funding (EUR): 5949665.0
Participants: 14
Project status: SIGNED

Several tens of millions of European citizens are partially edentulous and have insufficient bone for placement of dental implants. Following FP7 REBORNE project on bone regeneration, the MAXIBONE consortium coordinated by INSERM wishes to perform a randomized controlled clinical trial on alveolar ridge augmentation in mandibular and maxillary bone. This late stage clinical trial will aim at comparing the safety and efficacy of autologous bone grafting (gold standard) with culture expanded autologous bone marrow mesenchymal stem cells (MSCs) associated to a synthetic bone substitute covered by a resorbable membrane in 150 patients. The recruitment will be performed in 10 major hospital centres while the production of MSC will be done in the German and French blood transfusion institutes. Medical imaging, direct measurements and histology of core biopsies before dental implants will ensure the evaluation of bone regeneration. Cost-effective monitoring using a secured internet platform (eCRF) will produce a clinical database for evaluation of safety, efficacy and health costs in both arms. The participation of the innovative biomaterial SME Mimetis and the industrial leader in dental implantology Straumann will further contribute to the dissemination and exploitation strategies of future personalized regenerative medicine treatments in Europe.

Keywords: bone regeneration,randomized clinical trial,vertical bone defects,autologous mesenchymal stem cells,3d printed biomaterials
DevelOpmeNt of Cancer RNA TherapEutics (cONCReTE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Austria,Germany,Germany,Germany,Italy,Spain,Spain,Germany,Germany,Romania,Netherlands,Netherlands,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-05-01
End date: 2025-10-31
Duration (months): 66.0
Total project cost (EUR): 2060800.0
EU funding (EUR): 2060800.0
Participants: 17
Project status: SIGNED

Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness.

Keywords: cancer,cancer therapy
Maltese-European Linkages for Internationalisation, Innovation and Technology Transfer (MELIITA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Malta
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 51625.0
EU funding (EUR): 51625.0
Participants: 5
Project status: CLOSED

The MELIITA proposal will support the smart growth of the Maltese SMEs by increasing the efficiency and effectiveness of investments in research, development and innovation and to contribute to a better and more efficient connection of stakeholders and players along the innovation chain. It namely aims to: • Strengthen innovation capacity and to ensure Maltese beneficiaries of the SME Instrument receive the most appropriate support services throughout Phase 1 / Phase 2 based on identified weaknesses in their innovation capacities and so encourage the successful exploitation of their innovation project and to induce sustainable growth beyond the programme period. • Enhance innovation management capacity, thus rendering more efficient the full innovation process of Micro and SMEs, irrelevant of benefiting from the SME Instrument, and to help potentially good ideas effectively reach the market. • Stimulate an inter-disciplinary approach between cross-cutting technologies and transnational R&D cooperation, and • Create a more vibrant, innovative, competitive business community.

Keywords: innovation management,key account manager,sme instrument,competitiveness,growth
A strategic approach to increasing Europe’s value proposition for Additive Manufacturing technologies and capabilities (AM-motion)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Spain,Belgium,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Support for the further development of Additive Manufacturing technologies in Europe (H2020-FOF-2016, 2016)
Start date: 2016-11-01
End date: 2018-12-31
Duration (months): 26.0
Total project cost (EUR): 993052.5
EU funding (EUR): 993052.5
Participants: 13
Project status: CLOSED

Additive manufacturing (AM) has been highlighted as a key technology with potential for creating sustainable high value European based employment, addressing societal issues and supporting environmental sustainability. It has the potential to revolutionize the way in which products are manufactured and delivered to the customer. Moreover, AM is already having a high economic impact on several sectors and indeed on wider society. Therefore, it challenges the community to reinvent the business models and explore the implications of AM adoption. All those are heavyweight reasons for Europe to make specific efforts to define a plan of action in the field. In this framework, AM-Motion CSA has the ambition to develop a strategy and set up the pillars for its efficient implementation that, ultimately, will contribute to reinforcing the European AM ecosystem. The project will accelerate market uptake of AM technologies across Europe by connecting and upscaling existing initiatives and efforts around defined value chains, improving the conditions for large-scale, cross-regional demonstration and market deployment, and by involving a large number of key stakeholders, particularly from industry, as experts. AM-Motion will identify gaps at technical and non-technical levels for business development and propose specific actions and including a timeline to overcome them. More importantly, it will propose and validate models for business collaboration and unlock AM based business and jobs for Europe. To involve high number of key actors, the project has already achieved the support of several companies, research and education establishments, standardisation bodies, European Technology Platforms, international AM related entities, Regions and Innovation clusters. 52 support letters were received and are included.

Keywords: additive manufacturing implementation,market deployment,roadmap,digital manufacturing,business models,regional specialization,network
Development of a multi-stakeholder dialogue platform and Think tank to promote innovation with Nature based solutions (ThinkNature)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Italy,Switzerland,Belgium,Finland,Greece,Belgium,Greece,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Multi-stakeholder dialogue platform to promote innovation with nature to address societal challenges (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 3569788.75
EU funding (EUR): 2974163.75
Participants: 18
Project status: CLOSED

Nature-based solutions (NBS) aim to help societies to address a variety of environmental, social and economic challenges in sustainable ways. They are actions which are inspired by and supported by nature. Some involve using and enhancing existing natural solutions to challenges, while others are exploring more novel solutions, for example, based on how non-human organisms and communities cope with environmental extremes. NBS are energy and resource-efficient, and resilient to change, but to be successful they must be adapted to local conditions. The main objective of the present project is the development of a multi-stakeholder communication platform that will support the understanding and the promotion of nature based solutions in local, regional, EU and International level. Through dialogue uptake facilitation and steering mechanisms as well as knowledge capacity building, the ThinkNature Platform will bring together multi-disciplinary scientific expertise, policy, business and society, as well as citizens. This platform will be efficient, fluent to use and attractive to a wide variety of actors and stakeholders because it merges all aspects of NBS in a clear, pyramidal methodological approach. It will create a wide interactive society that builds new knowledge with a wide geographical scope. As a result, ThinkNature will provide the necessary policy and regulatory tools to solve significant societal challenges such as human well-being, tackling energy poverty, impacts of climate change, etc. through continuous dialogue and interaction.

Keywords: nature based solutions,multi stakeholders internet based platform,knowledge base,dialogue,decision mechanisms
Medieval landscapes in the Horn of Africa. State, territory and materiality of the Adal Sultanate (15th-16th centuries AD). (MEDLAND_HORN.AFRICA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This proposal will study the territory and the material remains of the Sultanate of Adal, a state which during the 15th-16th centuries controlled much of what it’s now Somalia and southern Ethiopia, organizing the international trade routes in the region and challenging the power of the Christian kingdom of Abyssinia until its collapse by the end of the 16th century. The history of this state is partially known through written sources, but has never been investigated from an archaeological point of view. This project will analyse how the different communities living in the Adal sultanate (nomads, urban dwellers, international traders) built a shared, cultural landscape and integrated it in one of the most successful trade networks in the world. Following a Landscape Archaeology perspective and using an innovative combination of methodologies and research strategies supported by GIS analytic tools, the project will present alternative interpretations to some of the most important topics in African archaeology: processes of urbanization, relationships between nomads and urban dwellers and continental and international trade routes. Beyond the study of a single archaeological case, the project will address key questions related to current challenges in the region and many other places throughout the world: episodes of religious conversion, environmental stress and climatic change; and will support the existing initiatives to preserve the archaeological and cultural heritage in the Horn of Africa.

Keywords: african archaeology,horn of africa history,archaeology of territory,trade networks,somalia,medieval archaeology,archaeology of state
CRO-EU-REKA! Research For Innovation, Innovation For People (CRO-EU-REKA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Croatia,Croatia
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-11-30
Duration (months): 19.0
Total project cost (EUR): 144750.0
EU funding (EUR): 107430.0
Participants: 3
Project status: CLOSED

The project “CRO-EU-REKA!” will carry out preparations, promotion, organization and impact assessment of the European Researchers' Night events to be organized in Zagreb and Split, the two largest cities in the Republic of Croatia, on 26th September 2014 and 25th September 2015. The main theme of the European Researchers' Nights in 2014 and 2015 in Croatia is "Innovation in Research, Innovation for People". The focus of the events is to highlight to young people, pupils and students the importance of innovation and creativity processes in research for the benefit of the society. The coordinator of the project is Business Innovation Croatian Agency (BICRO), the key governmental agency for innovation in science and SME sector, focusing on high-technology. BICRO, together with three selected partners: Society znanost.org, University of Split, and Faculty of Electrical Engineering and Computing at University of Zagreb will bring successful researchers with high innovation track records closer to the public at large, especially pupils and students in Croatia. The project intends to stimulate student's understanding and interest towards science and research as an attractive career and in general to enhance public recognition of researchers and their work in Croatia. The format of two events to be organized in two largest cities in Croatia (Zagreb and Split) for two consecutive years allows a unique swap of 10 central Eureka modules between the cities: the Modules organized and presented iin Split in 2014 will be moved to Zagreb in 2015, and Zagreb’s events in 2014 will be presented in Split 2015. Various activities during the Nights will be adapted and suited for a wide audience and will include different competitions, many Modules with science shows, scientist animators, exhibitions, projections, stands and many other surprises.

Keywords: science education,researchers night,science awareness,croatia
The impact of climate change on the uptake of arsenic into rice (RACe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-30
End date: 2020-03-30
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Rice is the staple food worldwide. Unfortunately, global rice yield is already falling behind population growth. One of the reasons for this is the presence of toxic arsenic (As) in many South(-East) Asian paddy soils, which is known to decrease rice growth and productivity. The current change in Earth’s climate is known to cause land loss due to desertification and inundation and lower (rice) crop yields, thus, threatening the global food security. According to the highest emission scenario for greenhouse gases presented in the 5th assessment report of the IPCC, global annual temperatures could rise by more than 5°C by the year 2100. How increased temperatures and CO2 concentrations affect As uptake into rice and ultimately the quality and production of rice is unknown and the main research question of this proposal. Rice will be grown in fully controlled growth chambers with elevated temperature and partial pressure of CO2, simulating the cli-mate of the year 2100. Besides determining changes in rice growth and grain yield, the amount of organic and inorganic As in the grain will be determined to assess rice quality. Furthermore, the biogeochemical pro-cesses occurring in the soil and atmosphere during climate change will be investigated and thus, will allow to understand the observed changes in rice yield and quality due to climate change. The amount and speciation of As will be quantified in the soil, plant, and atmosphere. Changes in microbial community abundance and richness will be assessed with modern pyrosequencing techniques. Functional microbial guilds of interest (iron and arsenic metabolizing bacteria) will be assessed by qPCR, pyrosequencing, and clone libraries. Overall, the knowledge obtained within the MSC-GF action on the impact of climate change on As uptake by rice will allow a better risk assessment for productivity of rice in the future and may give ideas for how to prevent a loss in rice yield and quality in a strongly climate impacted future.

Keywords: rice,arsenic,climate change,molecular microbiology,element cycling
European Union Contest for Young Scientists 2016 (EUCYS2016)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Belgium
Call: SCIENCE WAF SOCIETY (H2020-Adhoc-2014-20, 2015)
Start date: 2015-11-01
End date: 2016-12-31
Duration (months): 14.0
Total project cost (EUR): 891625.0
EU funding (EUR): 800000.0
Participants: 1
Project status: CLOSED

The present proposal is relevant to the organization of the 28th edition of EUCYS-European Union Contest for Young Scientists, to be held in Brussels from September 15th to 20th 2015. The Jeunesses Scientifiques de Belgique (JSB), the Belgian national organiser, has gathered a team, the organising Committee, to take on the great opportunity to welcome the European brightest young scientists in Europe. The team has built a large experience hosting for 29 years the Belgian national Expo-Sciences, the MILSET Expo-Sciences Europe 2000 and the MILSET Expo-Sciences international 2015 (ESI2015) – event that brought together 1000 participants from 60 different countries. It will be a great asset to the successful realisation of this event. By activating its large network of Schools, Professors and students it will contribute to greatly enlarge the impact and visibility of the event. Besides, it will be a unique opportunity to welcome this prestigious event in Brussels, the European Capital and to interact with all European dimension of the host city and region. This proposal contains the initial set of guidelines and actions to be taken to prepare the organisation of the EUCYS 2016, in terms of choice of organising dates; the choice of the Venue; accommodation according to predefined guidelines; communication plan and press conferences; and all elements necessary to make the EUCYS week a success. In This regard all the necessary elements needed to assess the readiness of the event will be portrayed in this document, including the draft programme, the financial planning, the main objectives that are to be achieved. The final aim of EUCYS 2015 is the promotion of science and technology among young people, according to the scopes of the Science with and for Society Programme within Horizon 2020.

Keywords: youth europe science contest belgium brussels 2016 eucys
Poverty, Child Protection and Parents' Participation (PCPPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The proposed project aims to promote innovative, poverty-aware forms of parents' participation and family inclusion practices in child protection policy and practice. More specifically, it intends to strengthen the connection between three bodies of knowledge—poverty, child protection, and parent participation. Parent advocacy programmes, that are gradually developed to support family inclusion and parents' participation at the practice and policy levels, are demonstrating positive outcomes, both in terms of proximal and distal outcomes. Even though, current programmes are mainly based outside of Europe and tend to lack a firm theoretical and ethical base that informs practice in ways that address poverty, other social inequalities, and child protection practice. Given the increasing numbers of children living in socio-economic hardship in more than two thirds of the OECD countries, alongside rising numbers of children involved in the child protection and court systems in various EU countries, developing such practices is a necessity for promoting the well-being and rights of children and Therefore the study aims are:(1) To map, describe, and conceptualize the development and application of parent advocacy programmes in England. (2) To explore the experiences and perspectives of all stakeholders who participate in parent advocacy programmes (3) To examine and theorize the relevance of poverty-aware approaches to parent advocacy programmes. (4) To empirically enrich and further develop the complex relationship between poverty and maltreatment. The research project will employ a qualitative in-depth case study approach that will involve a preliminary survey of all existing advocacy initiatives in England and in-depth inquiry of 4-6 parent advocacy programs. The case studies will include various qualitative methods and the analysis of the data will include thematic analysis and participatory data analysis.

Keywords: social work,poverty,child protection,child abuse and neglect,advocacy