Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A BIOmarker-based assay for prognosis and monitoring in renal TRANSplantation (TRANSBIO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-11-01
End date: 2016-03-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Kidney transplantation is the treatment of choice for patients with end-stage kidney disease (ESKD). However, although surgical techniques and postoperative care have greatly advanced, renal transplantation is not empty of challenges. The most important challenge is to achieve the long-term survival of the transplanted organ. Graft survival depends on the ability of the recipe of not rejecting the “foreign organ”. Rejection is a naturally occurring process triggered by a biological response of the immune system, which main function in the body is to defend it against infectious organisms and other invaders. As such, the immune system is prepared to reject a “foreign organ”, something that is nowadays prevented by prescribing immunosuppressive therapies to the patients for their whole life. However, the use of immunosuppressive therapies entails important problems. On one side, suppressing the immune system implies severe side effects like opportunistic infections, cancer and other severe malignancies. On the other side, even under immunosuppressive therapies, about 40% of transplanted kidneys are lost during the first 15-20 years and this is because of an immune response known as chronic rejection. Therefore, the major challenges in ESKD deal with avoiding the side effects associated with immunosuppressant drugs and avoiding chronic rejection. In the TRANSBIO project we aim at bringing to the healthcare market a patented (201500415) technology for efficient prognosis and monitoring of patients undergoing a kidney transplant based on a simple and non-invasive blood Considering that worldwide, the number of people receiving renal transplantation annually (incidence) is estimated at more than 1.4 million, representing a prevalence of about 5 million people; the TRANSBIO business opportunity seems unquestionable.

Keywords: kidney transplant
The disruptive Multifunctional Container Transfer System, a seamless & horizontal transfer of containers - low cost, more efficient utilisation in cargo freight and with care for the environment (M-CTS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Belgium,Netherlands,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-05-01
End date: 2021-12-31
Duration (months): 32.0
Total project cost (EUR): 3876399.2
EU funding (EUR): 2713479.44
Participants: 5
Project status: CLOSED

The overall vision is to bring our patented M-CTS solution to full market maturation, to pilot and to arrive at its commercialisation as a disruptive hydraulic mechanism that enables seamless and horizontal transfer of a container between semi-trailer and train wagon (or vice-versa) 3 times faster than current solutions. The seamless transfer between truck and train is the core to solve the limitations and unlock the potential of combined road/rail freight. M-CTS decreases OPEX, has 84% lower CAPEX for intermodal ports infrastructure and overall efficient use of space. M-CTS is rooted in the clear market-pull caused by the freight industry need to increase its efficiency and decrease environmental impact. It is the result of a previous EU-funded project leading to a verified and demonstrated prototype (TRL7) and confirmed the commercial and economic viability. For this project SLG developed a roadmap for technical improvements and a strategic business plan to enter the global freight market. Our FTI approach is to execute these plans, technically advance the M-CTS to TRL8 (WP1) and qualify the service in real-life operations to reach TRL9 (WP2). To support commercial viability, we will conduct a range of market maturation activities in WP4-5 and secure FTO and final business innovation plan in WP6. We bring together a strong consortium, the lead SME (SLG) with deep industry knowledge have teamed up with the world-class hydraulics manufacturer, JOST, and a large rail freight operator target user (Lineas), to successfully market launch and scale-up the ground-breaking M-CTS. M-CTS will create a measurable consortium impact - as accumulated revenues of €363m for the 5-year post-project, with accumulated net income of €113m and employment growth of 43 FTEs, and 120 FTEs in our value chain. Further, we will enable total cost savings for users of €100m in transshipment costs, and decreased CO2 emissions due to less fuel consumption of reach stacker or vertical cranes.

Keywords: freight industry,logistics industry,multimodal rail road transport,container transfer,multi modal,railway,transhipment
Safe Networks using P4 Programs (SafeNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Romania
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-05-31
Duration (months): 21.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Programmable hardware dataplanes such as the Barefoot Tofino enable unprecedented network flexibility, promising an ever-evolving set of network functionalities at hardware speeds, and are being rolled out in production. However, programming such dataplanes is very difficult as numerous bugs have been found even in trivial programs: accesses to uninitialized header fields, header stack underflows or overflows and processing of dropped packets. Verifying P4 programs before deployment is a great solution to make P4 programs safe. Recent research in this direction has shown that many bugs can be caught if (1) we know the concrete table entries at verification time (Vera, our work in Sigcomm 2018), or (2) if programmers express which rules are likely to appear in practice (p4v in Sigcomm 2018). Both approaches impose a high burden on the programmer, which reduces their applicability. In the CORNET ERC Stg project we have developed af4, a verification tool that finds all bugs and automatically fixes P4 programs without needing programmer input. The key insight behind our work is that verification need not consider all table entries because certain table entries will always result in faulty behavior for all matching packets and thus cannot appear in a correct deployment. af4 automatically generates predicates that filter out buggy table entries. If bugs are still reachable after predicate inference, af4 automatically adds a minimal number of keys to the existing tables and generates predicates that remove all bugs in the programs we tested. In this project we will explore the feasibility of commercial exploitation of af4: a) we will conduct a market study to understand potential customers; b) we will study possible approaches to commercialise af4 including open-source + consulting, cloud-based, or closed-source, and c) take steps towards commercialisation including the development of alfa-testing tools to be given to prospective customers.

Keywords: programmable networks,automated program verification and repair,network verification
At the roots of corruption: a behavioral ethics approach (Corruption Roots)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

For many years, human cooperation has been praised as beneficial in organizational and personal settings. Indeed, cooperation allows people to develop trust, build meaningful relationships, achieve mutually beneficial outcomes, and strengthen bonding with one's group members. However, while the benefits of cooperation are clear, very little is known about its possible negative aspects. Such negative aspects include the potential emergence of unethical conduct among cooperating partners, or as termed here – corrupt collaboration. Such joint unethical efforts, benefiting (directly or indirectly) one or more of the involved parties, occur in business, sports, and even academia. Corrupt collaboration emerges when one party bends ethical rules (here: lie) to set the stage for another party to further bend ethical rules and get the job done, that is, secure personal profit based on joint unethical acts. We propose that corrupt collaborations most commonly occur when all involved parties gain from the corrupt behavior. The current proposal is aimed at unfolding the roots and nature of corrupt collaborations; their existence, the psychological and biological processes underlying them, and the settings most likely to make corrupt collaboration emerge and spread. Accordingly, the information gathered in the current proposal has the potential to change the commonly held conceptions regarding the unidimensional – positive – nature of cooperation. It will help create a comprehensive understanding of cooperation and, specifically, when it should be encouraged or, alternatively, monitored.

Keywords: cooperation,ethical decision making,decision making,moral psychology
Modular laser based additive manufacturing platform for large scale industrial applications (MAESTRO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Germany,Germany,Spain,Italy,France,France,France,France,France,United Kingdom
Call: Photonics Laser-based production (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 3995905.0
EU funding (EUR): 3995905.0
Participants: 13
Project status: CLOSED

MAESTRO aims to develop and combine with existing Selective Laser Melting (SLM) techniques five innovations that will constitute the basis of a highly competitive manufacturing value chain: (1) a single pre-process software for a numerical chain combining all mandatory steps and configurations of SLM together with its related pre- and post-processes, (2) Hybridization of SLM with MIM, (3) Adaptive process control of SLM, (4) system level integration of a modular platform, (5) open access to an easy-to-use demonstration platform to reinforce to EU leadership in AM. These innovations will enable SLM to overcome the current limitations (speed, productivity, costs) to address large scale markets: productivity will be improved by 30%, cost reduced by 30% with quality towards zero defect. The performances of the MAESTRO platform will be assessed through a substantial number of demonstrators (7 in total: 4 brought by project partners, 3 selected through a EU-wide dissemination event). The MAESTRO consortium is composed of 10 complementary partners from 5 European countries. It is a well-balanced consortium with relevant expertise in SLM for tooling and aerospace applications (PEP), Materials and processes (CEA), Manufacturing technologies (UoB), Software Development (ALTAIR), MIM (OBE), SLM machine manufacturer (EOS). It is completed by 4 end-users from key sectors: Semiconductors and their packaging (III-V LAB), Automotive (CRF), Space (GEMMATE), Railway (ALSTOM).

Keywords: slm selective laser melting,powder bed additive manufacturing,design software,metal injection moulding,in line process control,hierarchical adaptive process control,feedstocks
Real-time precision tests of lepton universality (RECEPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-08-31
Duration (months): 75.0
Total project cost (EUR): 1986000.0
EU funding (EUR): 1986000.0
Participants: 1
Project status: SIGNED

The Standard Model (SM) of Particle Physics is the most accurate available description of nature at microscopic scales, yet it is in fundamental contradiction with cosmological observations and models which describe the macroscopic universe. For this reason, it is postulated that the SM is incomplete, and that additional particles and/or forces are needed in order to describe both microscopic and macroscopic reality in a coherent and self-consistent manner. If such additional New Physics does exist, precision measurements of the ways in which SM particles transform into each other should simultaneously disagree with certain SM predictions, and agree with the given New Physics model. Within this project, I will build a team of researchers dedicated to measuring one of the SM's most precise predictions, lepton universality (LU), with unprecedented experimental precision using the LHCb detector at the Large Hadron Collider (LHC) at CERN. In the current run, the LHC will deliver proton-proton collisions to LHCb until the end of 2018, allowing my team to make the world's most precise measurements of LU in the decays of beauty hadrons. Subsequently, the LHC will shut down for two years, and during this time the LHCb detector will be upgraded to allow it to collect five times more data per calendar year. This upgrade will allow my team to make the world's most precise measurements of LU in strange decays with data taken in 2021, significantly extending LHCb's physics programme. To make these measurements possible and take full advantage of the LHCb upgrade, my team will also optimize the reconstruction of the upgraded LHCb detector, making it possible to fully reconstruct and analyze the data produced in the detector in real-time. This approach, completely novel in High Energy Physics, will not only improve the sensitivity to LU in strange decays by up to an order of magnitude, but greatly expand the general physics programme of the upgraded LHCb detector.
Knowledge based design of complex synthetic microbial communities for plant protection (DeCoCt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1925500.0
EU funding (EUR): 1925500.0
Participants: 1
Project status: SIGNED

Complex microbial communities ("microbiota") that populate surfaces of higher organisms critically impact health of their hosts: They contribute to vital functions such as host fitness, nutrient acquisition, stress tolerance and pathogen resistance but are, at the same time, reservoirs for facultative pathogens or can promote pathogenesis. How and why communities shift from a beneficial to a detrimental state is largely unknown and we are far from utilizing identified mechanisms. In order to cure detrimental microbiota, that were damaged or reverted through stress factors including previous diseases, decoding the complex processes governing microbiota dynamics is a key challenge. To develop durable probiotics, communal stability or the ability of a community to return to a steady state following perturbation is a key factor. Our lab has broad expertise in studying microbial communities through lab experiments and analyzing factors that shape the microbiota of Arabidopsis thaliana plants under natural conditions and common garden experiments. We have discovered a hierarchical order in microbial community networks with hub microbes as key elements. A recent breakthrough was the discovery of microbial taxa that persist throughout the life of A. thaliana plants and their importance in network stability. In this project we will use our expertise to identify key stability factors and drivers of communal dynamics to reconstitute synthetic communities. How to seed microbial communities that develop into functional probiotics is a key challenge. We will use knowledge based assembly of complex communities to seeds protective microbiota. We will challenge those through pathogens and abiotic factors to refine and test the predictive power of our analyses. Therefore, DeCoCt represents a highly innovative approach that holds the potential to gain novel insights beyond the current scope of microbiota and probiotics research.

Keywords: holobiont,synthetic microbial communities,microbiota
Novel High-Power Single-Frequency Neodymium-Doped Fibre Lasers (NeoLaS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-17
End date: 2019-04-16
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Single-frequency lasers are crucial tools for a variety of applications such as atom cooling, metrology and sensing, among others. However, to date there are still uncovered wavelength domains due to technological challenges, especially in the 900-940 nm and 455-470 nm windows for applications demanding robust systems. This project mainly focuses on the investigation of novel high-power single-frequency lasers at these wavelengths, in both continuous wave and pulsed operation. The outstanding features of fibre laser technology make it the best option to surpass the power limitations of other technologies. To date multi-Watt neodymium-doped fibre lasers have only been demonstrated in a longitudinal multimode operation using resonant cavity configurations. The development of multi-Watt-level single-frequency lasers at 910-940 nm remains a challenge not yet achieved. However, in this project we propose a radical new approach which is based on novel exotic fibres doped with neodymium in a master-oscillator power amplifier configuration. Using this new approach, the applicant has already demonstrated a single-frequency fibre laser at 922 nm with 1 W output power during a post-doc position at the host centre. This preliminary results lays a solid foundation for the success of the project. The main goal of the project is to continue pushing beyond the state of the art, developing new, robust high-power lasers in the 910-940 nm wavelength range, and in the 455-470 nm window by second harmonic generation. The project aims to develop new laser systems for both advanced atomic physics and dermatological applications. This interdisciplinary project will combine the fellow’s expertise in single-frequency fibre lasers with the world-leading expertise of the host group in high-power low-noise lasers. In addition, the project will benefit from the host’s well-established partnerships with academia and industry actors at the forefront of photonics in France.

Keywords: single frequency laser,fibre laser,high power laser,low noise laser,master oscillator power amplifier,neodymium doped fibre laser
Integrated cascades of PROcesses for the extraction and valorisation of proteins and bioactive molecules from Legumes, Fungi and Coffee agro-industrial side streams (Prolific)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Italy,Italy,Italy,Italy,Germany,Germany,Spain,Italy,Cyprus,Belgium,Belgium,Greece,Switzerland,France,France
Call: Proteins and other bioactive ingredients from side streams and residues (H2020-BBI-JTI-2017, 2017)
Start date: 2018-09-01
End date: 2022-10-31
Duration (months): 50.0
Total project cost (EUR): 5362470.45
EU funding (EUR): 4672382.75
Participants: 19
Project status: CLOSED

Agro-industrial residual biomass, side streams and food production by-products like legumes, fungi and coffee are potential sources of valuable ingredients even though the routes for their exploitation are still at an early stage. Pursuing the ambition of achieving prolific valorization of untapped biomass streams, the project R%D&I activities and partners of Prolific have been positioned around a central innovation cycle that is mainly driven by industrial end-users who exactly know the needs of their customers and the technical constraints and industrial environment in their respective sector. The PROLIFIC project will apply a range of processing technologies to recover significant amounts of proteins/peptides and other value added compounds (e.g. carotenoids, phenols, caffeine and fibers) from industrial processing residues of legumes (seeds of peas, beans and chickpea), fungi (cuttings and mycelia of different species) and coffee (silver skin residue and not compliant roasted seeds). The economically and environmentally sustainable extraction, enzymatic modification, and conditioning techniques will be upscaled in industrially relevant environment. This will enable the production of consequent amounts of compounds and fractions necessary for the production of 16 product prototypes for the food, feed, packaging and cosmetic sectors. The Prolific project will assess the environmental, societal, ethical, safety, and regulatory issues at each step of the targeted value chains. SME and large companies strive at achieving competitive biomass exploitation and attracting when needed additional investors. The industrial partners business strategies for the future market penetration starts with the clear identification of the customer needs and goes up to the preparation of give-aways of food and cosmetics prototyped products as a reward for filling in questionnaires about the Prolific products along with intensive dissemination and communication.

Keywords: legumes,fungi,coffee,prototypes,extraction,enzymatic hydrolysis,bio active,ingredients