Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optical resonances for label-free biosensing (OPTIBIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-11-17
End date: 2011-11-16
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 2
Project status: CLOSED

In case of successful evaluation of the present application Robert Horvath plans to join to the Research Institute of Technical Physics and Materials Science (MFA) and can return work in his home country, continuing the momentum built up by 7 years of very fruitful research abroad. At the host institute a long term strategic plan is to build up a strong research direction in the field of bio- and chemical sensing and conduct basic and applied research in these fields. The applicant could strengthen this research direction with his relevant experiences in the field of optical waveguide based biosensors and their applications. Particularly, the present project aims to develop novel optical waveguide based sensors capable of supporting more detailed information about the structure of thin films or living cells with increased sensitivity in a label-free manner. This is achieved by designing and fabricating novel waveguide configurations supporting several modes and using different excitation wavelengths. Especially, novel Si and metal-oxide processing technology available at the host institute will be explored and combined with the applicants experience in soft lithography. The fabricated sensors will be applied to test and develop a novel sensor matrix based on functionalized protein assemblies for detecting small analytes and living cells. Theoretical modelling of these resonator structures and their sensing capabilities will be an important part of the research.

Keywords: physical sciences,optical biosensors,planar optical waveguide,sensor,grating coupler,label-free biosensing,evanescent waves
Design oriented flow distribution optimization of the solid oxide fuel cell stack operating under electric load. (HYDROSOFC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Solid oxide fuel cells (SOFC) offer high electrical efficiency of power generation, multifuel operation and internal reforming capabilities among other benefits. However, flow maldistribution of gas reactants among cells of the fuel cell stack and uneven utilization of the active cell area is one of the reasons for the performance loss in the scale-up process or even a stack failure at high electric load, high fuel utilization conditions. Efficient and uniform supply of reactants and removal of products was previously studied using computational fluid dynamics (CFD) methods. These methods, although accurate, require significant computing power, computing time and offer limited optimization capabilities. The flow networks modeling approach offers accuracy sufficient for the engineering design together with the accelerated optimization capabilities. It shows accuracy sufficient for engineering design optimization. In the proposed model, design oriented mass and flow distribution model of the SOFC stack, stack manifolds and flow channels are simulated as a network of differential hydraulic resistances. In order to simulate hydraulic network operation under electric load conditions, differential model of the SOFC cell (DCM) will be implemented and combined with the hydraulic networks model. In the DCM model, principal geometrical parameters of the cell will be implemented (electrolyte/electrode thickness, electrode porosity) together electrochemical performance characteristics, including polarization characteristics. The modeling results will explain physical mechanisms of flow distribution in the SOFC stack. They will also allow optimization of combined manifold and flow channels geometry under both no-load and electric load operation.

Keywords: solid oxide fuel cell,stack manifolds,flow distribution,polarization curve,efficiency
Development of Composite Nanomaterials for Hydrogen Energy Devices (DECNAHED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Latvia
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project will deal with development of new materials for emerging hydrogen and fuel cell technologies using nanotechnology approach. Main focus will be to develop low price novel composite inorganic/polymer membranes for electrolyser and fuel cell (PEM/DMFC) applications. The basic approach is to use a novel procedure for double cross-linking of sulfonated PEEK in order to improve the membrane stability and electrochemical performance in FC (patent application is submitted). The synthesis procedure is simple and it will not involve any expensive, and harmful and corrosive components. The membrane will be modified by adding inorganic nanoparticles and blending with polybenzimidazole (PBI). Standard characterization methods for membranes will be applied. Morphological studies and electrochemical and spectroscopic methods will be used as a basic ones for this project. However, from practical point of view the components are embedded in a macrosystems (fuel cell, electrolyser, battery) and they are exposed to real working conditions of device, which might include high electric current flow and high electric field gradient. It is limiting long term stability. About 0.1% power decrease per 1000 hrs is generally accepted for stationary applications, which is difficult milestone for nanomaterials. In this project the main focus will be on integrated approach. The membrane-electrode assembly (MEA) will be produced and material properties will study from point view of working assembly. In our Project the complex approaches combining aspects of device physics and nanotechnology and using multiphysics modeling will be used to address similar complex problems. Multiphysics modeling software Comsol will be applied in order to specify the device performance conditions and reactor designs under which the MEA degradation is minimized. Effort is planned to link the multiphysics modeling with practical experiment.

Keywords: proton conducting membrane,double cross-linking,fuel cells,nanocomposites,computer modeling
Biogenesis of Oncogenic MicroRNAs : from the structure of the microRNA processing complexes to the inhibition of the maturation of human oncogenes (ONCOMIRNA-BIOGENESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Micro-RNAs are a recently identified class of small non-coding RNAs that have been shown to regulate the expression of up to 30% of human genes. The contribution of miRNAs in gene regulation is gaining considerable attention, particularly given the growing links between miRNA mis-function or expression and disease. Certain miRNAs have been demonstrated to display oncogenic-like phenotypic effects and their overexpression is heavily implicated in the development of cancers. MiRNAs mature via a two-step pathway involving two processing complexes: first Drosha-DCGR8 and second Dicer-PACT-TRBP. The two ribonucleases Drosha and Dicer are recruited by multi-domain RNA-binding accessory proteins that interact with specific, but currently unknown, structural features present in immature miRNAs. In this project I propose to perform an ambitious and comprehensive multidisciplinary analysis of biomolecular interaction networks involved in human miRNA biogenesis. An automated molecular biology approach will be employed to rapidly clone, express and screen soluble domains derived from each modular processing protein. I will use the latest fast NMR methods to rapidly assess protein and RNA folds, and protein and RNA interaction sites. These results will define the roles of each biogenesis protein, describe RNA recognition mechanisms and reveal the first atomic resolution picture of miRNA processing complexes. This structural evaluation will form the basis for the design and testing of inhibitors of miRNA biogenesis. Over-expression of oncogenic miRNAs correlates well with cancer. I propose to evaluate the possibility of using anti-sense oligonucleotides to block the regions of the immature miRNA recognized by the biogenesis machinery. The efficacy of these molecules will be explored in vivo with the view to developing innovative ways of probing miRNA function or potential new cancer therapies.

Keywords: structural biology,nmr spectroscopy,biochemistry,biophysics,micro-rna,biogenesis,oncogenes,cancer
Role of the nuclear receptor Rev-erbalpha in lipid and glucose homeostasis and the transduction of circadian signals into metabolic responses. (GLUCOCLOCK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-09-01
End date: 2013-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The increasing incidence of obesity and type 2 diabetes is becoming a major health problem in the European Community and has a considerable economic and social cost. There is therefore an urgent need to understand the basics of these diseases. Physiological processes are subjected to natural daily fluctuations. Interestingly, daily cycles in insulin secretion and glucose tolerance are lost in patients with type 2 diabetes. There is an increased incidence of obesity, metabolic syndrome and cardiovascular disease among shift-workers. These observations pinpoint to a causal relationship between rhythm disturbances and metabolic disorders. Genes of the clock machinery directly influence energy homeostasis as exemplified by Clock mutant mice which are hyperphagic, become obese and diabetic. Metabolic pathways are tightly controlled nuclear receptors. For instance Rev-erbalpha is involved in lipid metabolism, bile acid synthesis and adipogenesis. Interestingly, Rev-erbalpha is also a clock and clock-controlled gene. Therefore Rev-erbalpha may coordinate metabolic processes and peripheral circadian outputs. The objectives of this proposal are: 1. To assess the role of Rev-erbalpha in lipid and glucose homeostasis and the development of insulin resistance and type 2 diabetes. 2. To determine whether Rev-erbalpha plays a role in the intricate link between peripheral circadian molecular clocks and metabolic pathways. This project will provide molecular basis to explain the interaction between circadian rhythms and lipid and glucose metabolism and may therefore suggest possibilities for new therapeutic approaches that take circadian rhythms into account. A long term possibility is the development of more finely tuned, and hopefully more optimal, treatments of dyslipidemia, insulin resistance and type 2 diabetes.

Keywords: nutrition related disorders,diabetology,physiology
A Quantitative Theory of Labor Supply with Heterogeneous Agents: From Individual to Macro Elasticities (LASUT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-09-01
End date: 2012-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aggregate response of labour supply to business cycle shocks is a central element in macroeconomic analysis and is the object of an important debate among economists. This debate matters as our understanding of the business cycle data and of the consequence of tax policies rely critically on the elasticity of aggregate labour supply. Because the standard macroeconomic analysis is based on a theory of a single (representative) individual, this analysis cannot distinguish between individual and aggregate labour supply. In an insightful paper, Chang and Kim (2006) construct a heterogeneous agent economy and find that the macro labour supply elasticity can be significantly larger than the micro elasticity. This proposal aims to develop a theory of labour supply decisions of heterogeneous individuals that is consistent with micro level data. The theory will be used to study issues in macroeconomic analyses that depend critically on the elasticity of labour supply: a) Can differences in income taxation account for the large differences in labour supply between North America and Europe? b) How does income taxation affect labour supply decisions across the heterogeneous individuals? c) Existing business cycle theory cannot account for the relative volatility of employment and hours per worker. Can heterogeneity in the labour force resolve this puzzle? d) How responsive are retirement decisions to changes in the social security system and in the tax code? How should the social security system be reformed to confront the demographic imbalances threatening its sustainability? This ambitious proposal will help the researcher to reintegrate among the European academics and will provide a clear input to the European research area. Luisa Fuster is eager to be one of the leading researchers of the IMDEA Social Sciences and to become a reference among European academics.

Keywords: macroeconomics,heterogeneous agents economies,taxation,social security reform,business cycles
Security Engineering for lifelong Evolvable Systems (SECURECHANGE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: Italy,Hungary,France,France,Belgium,France,United Kingdom,Norway,Spain,Austria,Germany
Call:  (FP7-ICT-2007-3, 2007)
Start date: 2009-02-01
End date: 2012-01-31
Duration (months): 36.0
Total project cost (EUR): 7069259.0
EU funding (EUR): 5100000.0
Participants: 13
Project status: CLOSED

There is growing demand to continuously evolve systems to meet changing business needs, new regulations and policies, novel technologies and computing infrastructures. Unfortunately, the pace of required change affects our ability to ascertain and maintain the quality of a system. Our objective is thus to develop techniques and tools that ensure "lifelong" compliance to security, privacy and dependability requirements for a long-running evolving software system. This is challenging because these requirements are not necessarily preserved by system evolution. The project will develop processes and tools that support design techniques for evolution, testing, verification, re-configuration and local analysis of evolving software. Our focus is on mobile devices and homes, which offer both great research challenges and long-term business opportunities. Concrete achievements will include: - Architectural blueprint and integrated security process for lifelong adaptable systems - Methodology for evolutionary requirements with tools for incremental requirements models evaluation and transformation - Security modelling notation for adaptive security with formally founded automated security analysis tools. - IT security risk assessment with tool-support for lifelong adaptable systems - Techniques and tools to verify adaptive security while loading on-device - Model-based testing approach for evolution The results are continuously validated jointly with key industry players.

Keywords: security
How well can humans perform: Testing human cue integration across multiple systems (CUE INTEGRATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Humans and all other animals are constantly engaged in making decisions based on partial, uncertain, noisy, and in some cases, expensive, cues. A central paradox in the study of decision making is the divergence between our extraordinary facility at perceptually-posed decisions and our very ordinary incompetence at cognitively posed ones. We plan to study the continuum between these ends of a spectrum, along with other, critical, characteristics for decision-making such as the effects of correlations between the cues. Our investigation will be based on, and contribute to, a range of quantitative models based on different computational and informational trade-offs.

Keywords: neuropsychology,cognition,perception,decision making
Emergent Connectors for Eternal Software Intensive Networked Systems (CONNECT)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: France,Italy,Germany,United Kingdom,France,Italy,Germany,United Kingdom,Sweden,China,France
Call:  (FP7-ICT-2007-3, 2007)
Start date: 2009-02-01
End date: 2012-11-30
Duration (months): 46.0
Total project cost (EUR): 6438956.0
EU funding (EUR): 4819875.0
Participants: 11
Project status: CLOSED

The CONNECT Integrated Project aims at enabling continuous composition of networked systems to respond to the evolution of functionalities provided to and required from the networked environment. At present the efficacy of integrating and composing networked systems depends on the level of interoperability of the systems&apos; underlying technologies. However, interoperable middleware cannot cover the ever growing heterogeneity dimensions of the networked environment. CONNECT aims at dropping the interoperability barrier by adopting a revolutionary approach to the seamless networking of digital systems, that is, synthesizing on the fly the connectors via which networked systems communicate. The resulting emergent connectors are effectively synthesized according to the behavioral semantics of application- down to middleware-layer protocols run by the interacting parties. The synthesis process is based on a formal foundation for connectors, which allows learning, reasoning about and adapting the interaction behavior of networked systems at run-time. Synthesized connectors are concrete emergent system entities that are dependable, unobtrusive, and evolvable, while not compromising the quality of software applications. To reach these objectives the CONNECT project undertakes interdisciplinary research in the areas of behavior learning, formal methods, semantic services, software engineering, dependability, and middleware. Specifically, CONNECT will investigate the following issues and related challenges: (i) Modeling and reasoning about peer system functionalities, (ii) Modeling and reasoning about connector behaviors, (iii) Runtime synthesis of connectors, (iv) Learning connector behaviors,(v) Dependability assurance, and (vi) System architecture. The effectiveness of CONNECT research will be assessed by experimenting in the field of wide area, highly heterogeneous systems where today&apos;s solutions to interoperability already fall short (e.g., systems of systems of systems).

Keywords: dependability,formal methods,interoperability,middleware,specification generation,system synthesis
An Innovative RFID Security SEAL for Aircraft Galley Trolleys (AIR-SEAL)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Slovakia,United Kingdom,United Kingdom,United Kingdom,Portugal,United Arab Emirates,Italy
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-08-01
End date: 2011-11-30
Duration (months): 28.0
Total project cost (EUR): 1309520.9
EU funding (EUR): 999480.7
Participants: 7
Project status: CLOSED

The AIR-SEAL project proposes the development of a second generation RFID security seal, capable of monitoring the integrity of an aircraft galley trolley or transportation vehicle. Since the September 11th terrorism attacks in the United States, catering services through-out the world have been seen as the weakest link in the aviation industry’s service supply chain. Existing sealing technologies are time consuming, ineffective and require a complex paper trail. A reusable and retro-fit, electronic sealing device is therefore required with an ultra-low profile. This new technology will enable the automatic sealing and inspections of galley trolleys, while improving their security by utilising a digital, anti-tamper volumetric sensor. With an initial market value of €120million retrofitting the technology and an additional €24milion per year in new trolleys, this market has the potential of significant economic returns. Beyond the catering industry this technology will enable international logistics services and all of the SMEs operating within a secure supply chain to seal their vehicles and reduce their operating costs. Supported by a location dependant (Galileo) tag interrogator and central ICT database, a pair of smart tags will be used to seal and monitor unauthorised access to a trolley, based on a received signal strength indication technology. Upon an authorised activation, the novel security seal will transmit its location and a randomly generated locking number to a central database, using a mobile GPRS communication link in the tag interrogator. By cross-referencing the tag and database values using a standard RFID reader, a security official may ensure that a seal has not been tampered with or replaced. A multi-lingual and bi-colour passive RF display will be installed onto each door of the trolley, for a visual indication of the seal status. Alternatively a RFID reader may be used for an automatic, long range inspection.

Keywords: aviation,security,seal,smart-tag