Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Observation and Modelling of Radiocarbon in Atmospheric Methane for Methane Source Identification (METHID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Observation and Modelling of Radiocarbon in Atmospheric Methane for Methane Source Identification Greenhouse gas emissions are the primary cause of global climate change, and methane (CH4) is the second most important contributor after carbon dioxide (CO2). Major sources of methane are both natural (wetlands) and anthropogenic (agriculture, landfills and fossil fuels). Current efforts to assess the anthropogenic CH4 influence on climate change and the effectiveness of mitigation policies for CH4 are limited by large uncertainties in estimates of total methane emissions and their attribution to various sources by accounting-based techniques. This project will pioneer and apply innovative techniques for atmospheric observation and modelling of radiocarbon in CH4 that will enable unique quantification of fossil fuel vs. biogenic CH4 sources at regional and global scales, thereby improving the estimation and attribution of CH4 emissions of different types. The proposed work will significantly advance the frontier of current research on atmospheric methane and the characterization of anthropogenic sources on policy-relevant scales, and it has the potential to influence climate policy and industrial practices over the next 10-20 years.
Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease (GCB-PRID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2023-02-28
Duration (months): 78.0
Total project cost (EUR): 1998066.0
EU funding (EUR): 1998066.0
Participants: 1
Project status: CLOSED

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can cause or contribute to autoimmune diseases. While major transcription factor networks regulating protective (or pathogenic) GCB cell responses have been identified and characterized, little is known about the post-transcriptional regulation by RNA-binding proteins (RBP), whose number rivals that of transcription factors. We postulate that RBPs exercise critical post-transcriptional control over germinal center B (GCB) and plasmacytic cell physiology and we aim to identify and molecularly characterize these regulatory mechanisms. To this end, we will complement sophisticated genetic mouse models with novel cell culture systems. We will monitor RBP activity with fluorescent sensors and use proteomics to reveal RBPs regulating the protein abundance of critical mediators of GCB and plasmacytic cell fates. In addition, we will conduct genetic screens to uncover relevant functions of a short list of 40 RBPs, whose protein expression we found to differ significantly between GCB and mantle zone B cells. Ultimately, we will use cellular immunology and RNA biochemistry to elucidate how these RBPs exert their post-transcriptional control. Through the integrated power of our multi-disciplinary approach we will thus pinpoint and investigate the functions of key RBPs regulating the biology of GCB and plasmacytic cells. GCB-PRID promises to uncover profoundly new insights into post-transcriptional regulation of adaptive immunity. Thereby, this groundbreaking research aims to reveal novel molecular targets for the treatment of autoimmune diseases, whose incidence is steadily on the rise.

Keywords: germinal center b cell,autoimmunity,plasma cell,rna binding protein,post transcriptional gene regulation
Predictive models and simulations in bone regeneration: a multiscale patient-specific approach (CuraBone)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Spain,Belgium,Belgium,United States,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-04-01
End date: 2021-03-31
Duration (months): 48.0
Total project cost (EUR): 1247425.92
EU funding (EUR): 1247425.92
Participants: 9
Project status: CLOSED

Bone injuries represent a high cost for the European health system, requiring corrective surgery to fix the bones. Traditionally, their treatment relies on classical orthopaedic techniques but, nowadays, it is possible to design and fabricate custom-made implants. Thanks to the current advance in image-based technologies, the reconstruction of models that are exact copies of patient specific bones is possible. Thus, this methodology is appropriate for preoperative surgical planning, but currently lacks of a predictive capacity. It presents a low impact for quantitatively determine the effectiveness of different treatments on bone regeneration and, consequently, the patient recovery. CURABONE aims to bridge this gap, integrating and extending numerical simulation technologies based on image analysis to achieve a predictive methodology, to optimize patient-specific treatment of bone injuries and rehabilitation therapies. Therefore, CURABONE will focus on the establishment of a currently non-existent, but essential multi-validation platform at different scale levels for the creation of bone models. At organ level, patient-specific loads will be quantified from image-based analysis and musculoskeletal rigid-body modelling. At implant level, Finite Element analyses (FEA) of bone and implant/scaffold will be evaluated. At cell level, in-vitro experiments will be developed under controlled microenvironmental conditions in bioreactors to estimate the cell response under different mechanical conditions. All this information obtained from validation at different scales will be integrated in a computational model with a predictive capacity. Hence, CURABONE will not only develop patient-specific musculoskeletal modelling based on FEA and bone adaptive algorithms, but will also bring a step-forward to validate these models at different scales together with supervision of different orthopaedic hospitals expert on bone injuries.

Keywords: patient specific models,personalized bone geometry and material properties,bone healing and,regeneration,computational implant design and optimization,computer aided tissue engineering
Integrated Cybersecurity Solution for the Vulnerability Assessment, Monitoring and Protection of Critical Energy Infrastructures (EnergyShield)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Ireland,Israel,Greece,Sweden,Bulgaria,Bulgaria,Romania,United Kingdom,United Kingdom,Luxembourg
Call: Cybersecurity in the Electrical Power and Energy System (EPES): an armour against cyber and privacy attacks and data breaches (H2020-SU-DS-2018, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 9858388.39
EU funding (EUR): 7421437.5
Participants: 23
Project status: CLOSED

The EnergyShield project will develop an integrated toolkit covering the complete EPES value chain (generator, TSO, DSO, consumer). The toolkit combines novel security tools from leading European technology vendors and will be validated in large-scale demonstrations by end-users. The EnergyShield toolkit will combine the latest technologies for vulnerability assessment (automated threat modelling and security behaviour analysis), monitoring & protection (anomaly detection and DDoS mitigation) and learning & sharing (security information and event management). The integrative approach of the project is unique as insights produced by the various tools will be combined to provide a unique level of visibility to the users. For example, it will be possible to combine vulnerability scanning with automated threat modelling to provide insights into software vulnerabilities present in an architecture in combination with insights into what are the key assets, risks and weak links of the architecture. The toolbox will allow end-users to predict future attacks (as it provides insights to what attacks can be applied to the weakest links of the architecture) and learn from past attacks (for example using the insights from the vulnerability assessment and threat modelling to prevent attacks, and learning from attacks to update the probabilistic meta-model of the threat modelling). The toolkit will be implemented with the complete EPES value chain who will contribute to the specification, prototyping and demonstration phases of the project. Although the toolkit will be tailored to the needs of EPES operators, many of the technology building blocks and best practices will be transferable to other types of critical infrastructures. The consortium consists of 2 large industrial partners (SIVECO and PSI), whereof SIVECO is taking the lead supported by 6 innovative SMEs, 3 academic research organizations and 7 end-users representing various parts of the EPES value chain.

Keywords: vulnerability assessment,cybersecurity culture,anomaly detection,ddos mitigation,siem
Archaeometric Analysis of Maltese Prehistoric Pottery (MaltaPot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Malta
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 161193.6
EU funding (EUR): 161193.6
Participants: 1
Project status: CLOSED

Ceramic pots are an enduring and resilient document of ancient culture. Often specific to time and place, they are a valuable record which can enlighten our understanding of ancient chronologies, aesthetics, technologies, trade networks and cultural ties. The Maltese islands have a particularly rich, diverse and dynamic ceramic assemblage covering the entire prehistoric period. While the later ceramic assemblages of Bronze Age Malta have received considerable study over the past decade, little archaeometric research has been conducted on the earlier ceramic phases. MaltaPot will address this by exploring the emergence of the earliest prehistoric ceramic phases (namely Għar Dalam, Skorba and Żebbuġ 5000-3800BC) through a series of multi-disciplinary laboratory-based methods including typological analysis (3D laser scanning and digital classification software) and material studies (optical microscopy, LIBS, XRF and XRD). Findings from this project will dramatically increase understanding of the earliest settlers on the Maltese islands and it will also have wider implications for our understanding of Mediterranean archaeology during this important period of Neolithic colonisation by exploring cultural links through typological, technological and material studies. MaltaPot will develop new methodologies for the archival and analysis of prehistoric ceramic assemblages and also advance new methods of displaying and dissemination of results to both the wider public and academics. The fellowship will contribute to the researcher’s career development through the acquisition of advanced skills in archaeometric approaches to ceramic analysis as well as developing skills within the heritage sector through a series of events designed to disseminate her results to the wider public. The project will also serve to consolidate and extend the researchers network of professional contacts within Europe and beyond.

Keywords: malta,ceramics,prehistory,archaeometric,archaeology
Characterization of the Interaction between wing and CLosely Operating Propeller (CICLOP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Aerodynamics experimental characterization and new experimental testing methodologies for distributed electrical propulsion (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2020-12-01
End date: 2023-03-31
Duration (months): 28.0
Total project cost (EUR): 847687.5
EU funding (EUR): 847687.5
Participants: 1
Project status: SIGNED

Scheduled commercial transport volume is continuously growing, representing the global megatrend "Mobility". The subsequently higher number of aircrafts requires new and low energy concepts to achieve the European goals for sustainable aviation. Distributed (Electric) Propulsion (DP/DEP) is such new technology which opens up the design space and promises significant increase in overall aircraft efficiency while reducing emissions. A sound and reliable prediction of the aerodynamic effects of DP/DEP and close wing coupling at high-lift based on aerodynamic models and simulation is not yet available. The overall objective of CICLOP is to close this gap by providing high fidelity experimental data that allow for a leap in aircraft performance due to efficient synergetic use of DP and wing interaction. The most dominant design parameters, driving the sensitivity of positive as well as adverse aerodynamic effects will be identified and quantified. The results will thus significantly increase the conceptual and pre-design know-how for DEP/DP driven aircraft and allow for off-design performance prediction and sensitivity identification. Therefore, the CICLOP project members will: • Build and test a versatile wind tunnel model coupling three propeller sizes of different thrust to a wing of 0.8m chord including a high-lift flap, droop-nose a deflectable spoiler. • Identify aerodynamic interactions mechanism up to flow separations by the means of local static pressure measurement combined with oil flow visualization, hot-film techniques and PSP. • Assess the design parameters for propeller design and propeller to wing coupling. • Strengthen the competitiveness of the EU industry and supply in the field of new technologies for regional aircraft, following REG IADP activities for preliminary studies on hybrid/electrical regional aircraft configurations. The CICLOP total grant request is 847.688€ and will be conducted within 28 months.

Keywords: wind tunnel,pressure sensitive paint,distributed electric propulsion and wing interaction,aerodynamic effects,aircraft efficiency,off desing performance prediction,sensitivity identification
Optimised Real-world Cost-Competitive Modular Hybrid Architecture for Heavy Duty Vehicles (ORCA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Italy,Italy,Germany,Belgium,Belgium,Sweden,France,Netherlands,United Kingdom
Call: System and cost optimised hybridisation of road vehicles (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 10192029.13
EU funding (EUR): 8310755.13
Participants: 14
Project status: CLOSED

The ORCA Project proposal addresses topic GV-03-2016, of the Transport Work Programme. The work proposed will, in a single coordinated project, address all the aspects of the domain 2 “For pure and plug-in hybrids, power-train system integration and optimisation through the re-use of waste heat, advanced control, downsizing of ICEs, innovative transmissions and the integration of electronic components” regarding Heavy Duty Vehicles. The activity proposed will be conducted by an 11-member consortium from 7 different European Members States representing all requested competencies in the field of powertrain optimization for Heavy Duty vehicles. The consortium comprises OEMs with IVECO-ALTRA, CRF and VOLVO (also members of EUCAR, suppliers VALEO, BOSCH, JOHNSON MATTHEY and JSR MICRO (CLEPA), leading Engineering and Technology Companies/organizations and Universities with TNO, FRAUNHOFER, and VUB (EARPA). The majority are also active members of ERTRAC and EGVIA. The overall objectives of the ORCA project are: Reduce the TCO to the same diesel vehicle TCO level, targeting over 10% system cost premium reduction compared to actual IVECO hybrid bus and VOLVO conventional truck with the same performances, same functionalities and operative cost, and also targeting up to 10% rechargeable energy storage (RES) lifetime/energy throughput improvement. Improve the hybrid powertrain efficiency up to 5% compared to actual IVECO hybrid bus and conventional truck through optimized RES selection & sizing and by improving the energy and ICE management. Reduce the fuel consumption by 40% compared to an equivalent conventional HD vehicle (bus & truck). Downsize the ICE by at least 50% compared to actual IVECO hybrid bus and VOLVO conventional truck. Improve the electric range from 10km to 30km by adding the PHEV capabilities and optimising the RES capacity. Case study assessment to replace a diesel engine by a CNG engine for future heavy-duty vehicles.

Keywords: hybrid electric vehicle,system optimisation,heavy duty,cost reduction,real world,modular architecture,hybridisation
Setting the framework for the enhanced impact of SPIRE projects (SPRING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Coordination and support actions
Partnership: SPIRE (cPPP)
Countries involved: Spain,Italy,Belgium,Switzerland,United Kingdom,United Kingdom
Call: Support for the enhancement of the impact of SPIRE PPP projects (H2020-SPIRE-2017, 2017)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 499368.75
EU funding (EUR): 499368.75
Participants: 6
Project status: CLOSED

Increasing industrial uptake of project findings is at the heart of project SPRING. It is the essential building block for ensuring greater impact of SPIRE projects and therefore progress towards the SPIRE roadmap goals of increased resource and energy efficiency in the EU process industries. Instead of focusing on a small cluster of projects, SPRING has been developed to provide the mechanism to enhance the impact of all SPIRE projects. Project SPRING’s objective is to increase progress towards the SPIRE goals and enhance return on investment in projects by addressing the needs of those who make the decisions to adopt process innovations in industry and barriers to their adoption. It will do this by providing guidance to project participants, decision makers in industry and broader SPIRE stakeholders, enabling them collectively to: 1. Improve the articulation of the value of project exploitable outputs 2. Improve the articulation of industry needs and barriers-to-uptake of exploitable outputs 3. Improve the mapping of project value to industry needs 4. Identify policy gaps and recommendations to improve project impact To address these objectives, the project will deliver six sets of exploitable outputs: A – Guidance on best practice of how to measure progress, impact and success of SPIRE projects. B – Frameworks for getting different levels of project results to the right audience through the spire2030.eu portal C – A model for mapping project outputs to industry needs, through thematic, interactive industry workshops, expert input and technology scanning methods. D – Guidance for understanding business barriers to uptake, including best practice for enabling good decision making when evaluating project outputs. E – A package of training and network groups to upskill SPIRE project participants F – Identification of policy gaps and future SPIRE needs

Keywords: enhancing impact of spire projects
circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Israel,Spain,Germany,Italy,Germany,Netherlands,Netherlands,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-09-30
Duration (months): 57.0
Total project cost (EUR): 3865078.52
EU funding (EUR): 3865078.52
Participants: 12
Project status: CLOSED

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

Keywords: circular rnas,non canonical splicing,computational biology,biomarkers,brain diseases