Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating the role of bacteria-produced siderophores in satisfying diatom Fe requirements. (IRONCOMM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The greatest impact of climate change will be exerted on ocean biomes. In order to mitigate for its effects it is paramount to understand the dynamics of phytoplankton communities within, which are responsible for marine carbon fixation (50% of the of the primary production on Earth). Our current understanding of phytoplankton dynamics is limited – particularly when linking a molecular level understanding of metabolic processes with ecology. In the proposed work I will investigate the hypothesis that diatoms, which are ubiquitous phytoplankton species across all marine habitats interact with bacteria to acquire bioavailable iron from siderophores produced by the latter. My investigations will address this aim across all scales of biological organization. I will capitalize on preliminary investigations at the host laboratory that have begun to unravel the molecular pathways associated in siderophore acquisition in diatom species. My work will be novel in terms of characterizing the molecular mechanism by which siderophores are transported into and distributed to where required within diatom cells. Further, I will explore the hypothesis that siderophore acquisition is a result of mutualism between bacteria and diatoms. The results will bear important eco-evolutionary consequences to our understanding of microbial communities. Finally, on a global scale, I will quantify the relevance of my findings by mining of metatranscriptomic data collected in global transects of the ocean (specifically during the Tara Oceans expedition). Through this fellowship I will develop a range of new technical skills including novel molecular techniques and bioinformatics, as well as transferable competencies (e.g. using French at work). The fellowship will provide me with an opportunity to return to Europe (from the USA), expanding my academic network of collaborators and putting me in a prime position for applying for faculty positions as a next step in my academic career.

Keywords: microbial ecology and evolution,environmental and marine biology,siderophores,iron,ocean acidificaiton,marine diatoms,microbial communities
Nutrient recovery from biobased Waste for Fertilizer production (NewFert)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Germany,Spain,Austria,Spain,France
Call: Nutrient recovery from biobased waste streams and residues (H2020-BBI-PPP-2014-1, 2014)
Start date: 2015-07-01
End date: 2018-12-31
Duration (months): 42.0
Total project cost (EUR): 2419740.0
EU funding (EUR): 1209520.5
Participants: 6
Project status: CLOSED

Biowaste valorisation is an attractive approach in the framework of the EU Waste Management policies and the development of a circular economy. Waste from biostreams and different biobased sources are being under-utilised as potential resource of valuable compounds. Fertilisers play an important role as suppliers of nutrients relying on their production heavily on fossil mineral resources. European Fertiliser industry is besides very dependent on imports of these raw materials, being vulnerable to supply and pricing policies. Main objective of the proposal is to build up a breakthrough concept of Fertiliser Industry, strengthening European competitiveness and boosting the biobased economy potential, through the development of a new value chain, which will achieve turning solid and liquid residues, specifically ashes of different origins and livestock effluents, into high quality valuable products, a new generation of fertilisers. NEWFERT will focus on a viable and cost-effective industrial nutrient recycling scheme, developing new biorefining technologies aimed at increasing nutrient recovery ratios and mitigating environmental and socio-economical impact of the current fertilisers by replacing non renewable and fossil nutrients with biobased materials in their composition. Projected benefits also include substantial energy savings and CO2 emissions reduction. NEWFERT aims to decrease raw material dependency, prevent resource depletion and reduce the environmental impact increasing significantly the Fertiliser industry sustainability. The work organisation has been designed to link and pursue a successful industrial integration supported by a solid life-cycle cost analysis. The strategy of the work plan is based on 8 workpackages. NEWFERT consortium is lead by FERTIBERIA and composed by a balanced set of 6 partners from 4 European Union member countries: biobased industries, SMEs, RTOs and academic institutions covering nutrients recovery from biobased waste field.

Keywords: recovery,biowaste streams,food value chain,nutrient valorisation,fertiliser,recycling,biomass production,new biorefining technologies
The Human Jigsaw: Matching articulating skeletal elements from mass burials (Human Jigsaw)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-05-13
End date: 2021-05-12
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 1
Project status: CLOSED

The “Human Jigsaw” will address the key issue of sorting commingled human remains, by amalgamating state-of-the-art techniques in three dimensional geometric morphometrics and machine learning. The deposition of multiple bodies in mass graves has been common practice worldwide after warfare, natural disasters or as part of the funerary treatment of the deceased. In Cyprus, where this project is to be materialized, the events that took place in 1963-64 and 1974 have resulted in an unspecified number of individuals having been buried in mass graves, of which over 2000 Greek and Turkish Cypriots are still missing. Commingling, the mixing of the skeletal elements of different individuals, is a grave issue in such contexts. A major limitation of current methods for sorting the remains of different individuals is that they do not effectively take into account the three-dimensional morphology of adjoining surfaces. The “Human Jigsaw” will focus on matching the main elements of the lower skeleton (os coxae, femora, tibiae), which are the elements that provide basic biological profile information (age, sex and stature). The produced methods will be subsequently applied in Minoan and pre-Mycenaean assemblages, addressing issues of the post-mortem treatment of the dead. The “Human Jigsaw” will have major implications in forensic anthropology as it will facilitate the identification of unknown subjects. In bioarchaeological contexts, the results of this project will have implications in archaeothanatology and funerary taphonomy by allowing a more accurate assessment of the palaeodemographic profile of the deceased who were deposited in mass burials.

Keywords: osteoarchaeology,forensic anthropology,machine learning,human osteology
SMART LIVING HOMES - WHOLE INTERVENTIONS DEMONSTRATOR FOR PEOPLE AT HEALTH AND SOCIAL RISKS (GATEKEEPER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Innovation actions
Countries involved: Ireland,Germany,Spain,Spain,Italy,Italy,Italy,Spain,Spain,Spain,Italy,Spain,Spain,Italy,Italy,Israel,Cyprus,Hong Kong,Taiwan, Province of China,Belgium,Greece,Greece,Greece,Poland,Greece,Switzerland,Switzerland,Greece,Switzerland,Sweden,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Smart and healthy living at home (H2020-SC1-FA-DTS-2018-2, 2018)
Start date: 2019-10-01
End date: 2023-12-31
Duration (months): 51.0
Total project cost (EUR): 23830065.31
EU funding (EUR): 19598327.19
Participants: 53
Project status: SIGNED

The main objective of the Project is to create a GATEKEEPER, that connects healthcare providers, businesses, entrepreneurs, elderly citizens and the communities they live in, in order to originate an open, trust-based arena for matching ideas, technologies, user needs and processes, aimed at ensuring healthier independent lives for the ageing populations. By 2022, GATEKEEPER will be embodied in an open source, European, standard-based, interoperable and secure framework available to all developers, for creating combined digital solutions for personalised early detection and interventions that (i) harness the next generation of healthcare and wellness innovations; (ii) cover the whole care continuum for elderly citizens, including primary, secondary and tertiary prevention, chronic diseases and co-morbidities; (iii) straightforwardly fit “by design” with European regulations, on data protection, consumer protection and patient protection (iv) are subjected to trustable certification processes; (iv) support value generation through the deployment of advanced business models based on the VBHC paradigm. GATEKEEPER will demonstrate its value by scaling up, during a 51-months work plan, towards the deployment of solutions that will involve ca 40.000 elderly citizens, supply and demand side (authorities, institutions, companies, associations, academies) in 8 regional communities, from 7 EU member states.

Keywords: early detection and intervention of social and health risks
A new approach of metastatic bone fracture prediction using a patient-specific model including metastatic tissue, daily-life activities and local failure criteria (METABONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-15
End date: 2022-06-14
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Osteolytic bone metastases are responsible for long bone fracture leading to restricted mobility, surgery, or medullar compression that severely alter quality of life and have a huge socio-economic impact. Current fragility scores to estimate the fracture risk in patients with metastatic femur are based on qualitative evaluation from Quantitative Computed Tomography (QCT) scans and lack sensitivity and specificity. Efforts are now made towards the development of patient-specific finite element models to assess the strength of tumoral bone segments, but their accuracy is hampered by several limitations, including limited knowledge of metastatic bone mechanical properties, simulations performed only for single stance loading condition, and simulations providing a global failure criteria. The aim of METABONE is, therefore, to use a novel approach to better predict the fracture risk of metastatic femur. A patient-specific finite element model will be developed based on QCT scans, which will include the real material properties of ex vivo human metastatic bone determined experimentally in the first part of the project. The composition and mechanical behaviour of diseased bone tissue are hypothesised to be rather different from healthy tissue and influential of femoral strength. This model will be used clinically on patients with osteolytic lesions located in proximal femur to assess the fracture risk during daily life activities, using a local failure criteria and a range of different loading conditions. This novel methodology, combining experimental and numerical approaches, is expected to significantly improve the accuracy of fracture risk prediction. Successful completion of METABONE will have the potential to guide clinical decision making, by providing clinicians with a more accurate tool to optimize locomotor strategy and oncology program, in order to prevent bone fracture, improve survival and quality of life of the patients.

Keywords: biomechanics,metastatic femur,indentation,raman spectroscopy,computed tomography,finite element simulations,daily life loading conditions,local failure criteria
Sustainable Urban Consolidation CentrES for conStruction (SUCCESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,France,France,Luxembourg
Call: Reducing impacts and costs of freight and service trips in urban areas (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3238117.5
EU funding (EUR): 3238117.5
Participants: 11
Project status: CLOSED

Currently freight transport represents 40% of the total transport emission and 32% in urban area. Many initiatives are under development to reduce costs and negative impact of freight and service trip in urban area. Some of them concern supply chain improvements and more specifically consolidation centre projects. Few study cases are dedicated to construction industry. However, urban population tends to grow, increasing the need to develop and reconstruct urban centres. Construction material logistic impact in urban area will intensify in terms of costs and negative impacts in urban area. Yet, only few experiences of Construction Consolidation Centres can be found. Among these initiatives, four are construction site specific (Stockholm, Utrecht, Berlin, London Heathrow) and only one is dedicated to several construction projects (London CC). Theses pilots studies have demonstrated reduced transportation impacts, positive effects on transportation efficiency and construction site productivity. Several limitations to the transferability of this concept are identified: one on hand the demonstrators were implemented in specific contexts (regulatory incentives, cities investment contribution, and specifics transport and logistics infrastructure issues) which are not the same in France, Spain, Italy and Luxembourg. On the other hand, economic viability has not been demonstrated. The project addresses the different requirements for transferability of supply chain optimization concepts as well as CCCs and new ways of working between supply chain stakeholders. The approach is to identify an integrated collaborative approach and business model among construction supply chain actors. Three main steps will be performed: analyse the current issues along the construction supply chain, propose several optimization scenarios regarding these issues, simulate and analyse costs optimization and environmental impacts to propose new partnership opportunities based on savings distribution

Keywords: construction consolidation centre,business model,supply chain,collaboration partnership,sustainable transport,reverse logistics,construction site performance
The relationship between cristae shape and mitochondrial protein import in mitochondrial disease models (CRIMIPRIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

The majority of mitochondrial proteins are imported from the cytosol into the organelle. The main mitochondrial protein import pathways account for the import of mitochondrial matrix and mitochondrial inner membrane (IM) proteins, e.g. the subunits of the respiratory chain complexes (RCC). This import process is facilitated by mitochondrial IM and outer membrane (OM) contact sites. Furthermore, the aforementioned pathways depend on the IM elechtrochemical gradient and ATP to take place. The host lab showed that mild overexpression of the dynamin-related protein optic atrophy 1 (OPA1) protects against IM proton electrochemical gradient lost upon complex III inhibition. OPA1 is involved in RCC stabilisation and cristae remodeling, but also in mitochondrial IM and outer membrane contacts. Recently, lower levels of mitochondrial import receptor and channels proteins were linked to Parkinson disease. The hypothesis of this proposal is that OPA1 directly influences TIM23 and TIM22 protein import pathways. This fellowship will follow three main aims; a) define the relationship between OPA1 and protein import in models of Leigh syndrome, b) determine cristae integrity in TOM20, TIM23 and TIM22 deficient cells and c) define protein import machinery molecular partners of OPA1. I will use classical biochemistry and BN-PAGE gels to determine the integrity of TIM23 and TIM22 and to assess the mitochondrial import capacity in the mouse models. Next, I will measure by electron microscopy the shape of the cristae and perform detailed morphometric analyses to determine if the protein import plays a role in cristae biogenesis. Finally, using complexomic analysis, I will aim to identify potential import pathway partners of Opa1 and establish their role by their deletion by CrispR/Cas9 in Opa1tg cells. This research will open the possibility to target the import machinery to remodel cristae in mitochondria in an OPA1-dependant manner as an alternative to treat mitochondrial disorders.

Keywords: mitochondria,mitochondria biogenesis,protein import,mitochondria inner membrane,mitochondria outer membrane,respiratory chain complex,electrochemical gradient
Demonstrating more efficient enzyme production to increase biogas yields (DEMETER)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Germany,Germany,Belgium,Netherlands,Netherlands
Call: Overcoming low product yields from fermentation processes (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-08-01
End date: 2020-01-31
Duration (months): 42.0
Total project cost (EUR): 6539557.5
EU funding (EUR): 4629586.0
Participants: 8
Project status: CLOSED

Genencor International BV has recently developed a new enzyme product, C1-LC4, that in recent field trials has shown a promising 10% cost-reduction in the production of biogas from organic waste. Although the efficacy of the enzyme has clearly been shown, the current fermentation process does not provide sufficient yield in industrial production to be cost-effective for large-scale application. The objective of DEMETER is to increase the yield of this industrial fermentation process by at least 20%, improve the product recovery process by 40%, and reduce overall product cost by at least 15% while increasing the productivity of the process. In addition, DEMETER will demonstrate the efficacy of the enzyme in 8 field trials in biogas plants throughout Europe. The DEMETER consortium includes the entire value chain: enzyme producer Genencor International, enzyme retailer Miavit, the pilot plant BioBase Europe Pilot Plant, anaerobic digester expert OWS, independent biogas research centre DBFZ, Ciaotech for independent economic and environmental evaluation, and large farm, Biomoer, for field trials. DEMETER follows a multi-scale approach. First, the enzyme productivity will be improved on lab- and small pilot-scale, while obtaining insights for further scale-up. In parallel, the effect of enzymes on biogas yield will be quantified, using 5 commonly used biomass substrates. The improved fermentation and downstream process will be scaled up and demonstrated in a 15 000 L pilot plant. Finally, the improvement of the biogas production process due to the use of the C1-LC4 enzyme will be demonstrated in practice in 8 field trials. The results of these field trials will be fed back to further improve the production process and its yield. Ultimately, DEMETER will not only produce a fermentation process with increased yield, an improved product recovery process resulting in reduced production costs. The resulting product will lead to an increase in renewable biogas production in Europe.

Keywords: anaerobic digestion,fermentation,biogas production,myceliophthora thermophila
ORigin determination and improved detectAbility of Celestial-to-Local phEnomena by the VLF technique (ORACLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-08-05
End date: 2024-08-04
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The lower ionosphere (70–90 km), a ionized region in the Earth’s upper atmosphere, can be understood as a membrane acting as a sensor to different kinds of phenomena originating at Earth (e.g., lightning) or in space (e.g., space weather). Unexpected strong changes in this region can influence dramatically the performance and reliability of navigation and communication. However, the impact of those phenomena in this region is difficult to quantify accurately. On one hand, this region is too high for balloons and on the other hand it is too low for satellites. In this project, Very Low Frequency (VLF) radio waves will be used because they propagate between the Earth surface and the ionosphere with low attenuation. The researcher will push forward novel scientific understanding of the properties of the lower ionosphere and magnetosphere. She will: (1) determine whether the day-to-day variability of the VLF signal during sunrise can be explained by the ozone variability at its upper boundary, (2) find the yet unknown generation mechanism of VLF banded emissions, and (3) improve the detectability of galactic gamma-ray bursts, known as the most energetic phenomena in the universe. The project is strongly multidisciplinary, involving perspectives and concepts from astrophysics, magnetospheric, ionospheric, atmospheric physics and big data handling. This will be developed by the researcher within the frame of interaction and cooperation with the host and secondments. The results of this proposal have the potential to convey new perspectives in ionospheric and magnetospheric studies and provide some answers to long standing issues within the field of space weather, which has become of central importance in many aspects of human life and industry. As a consequence, by completing this action, Europe will improve its know-how in the topic of this proposal and reinforce its position on a global scale. This project is in line with the EU commission sector on Space and Security.

Keywords: d region,ionospheric disturbances,radio propagation,earth ionosphere waveguide,magnetospheric waves