Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cut-and-paste conjectures and multicurves (CAPCAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1444860.0
EU funding (EUR): 1444860.0
Participants: 1
Project status: SIGNED

Knot theory has seen extraordinary developments over the past decades. The arrival of modern homological knot invariants has had far-reaching implications beyond low-dimensional topology, giving insight into old problems through deep ties between knot theory, algebraic geometry, representation theory, Floer theory, and physics. My ERC project aims to establish a new perspective on knot homology theories using a new type of invariants, so-called multicurves. As objects of Fukaya categories of simple surfaces, these multicurve invariants make local versions of knot homology theories amenable to essentially combinatorial techniques. Thanks to their exceptional geometric and gluing properties, multicurves are ideally suited to implement the divide-and-conquer principle for attacking hard open problems. In fact, I have not only been directly involved in the definition of three of these invariants, but I have also applied them to resolve several open conjectures in the field already. The purpose of my research programme is to investigate fundamental open problems in low-dimensional topology that require a deeper understanding of the new technology of multicurves. To this end, I will pursue the following four lines of basic research: I will investigate the topological properties of the new invariants and their relation to classical invariants. I will explore the existence of local versions of various spectral sequences that are known to relate knot homology theories. I will make the invariants more computable. Finally, I will apply the generic principles that underlie the definition of multicurves to other settings.

Keywords: low dimensional topology heegaard floer theories khovanov theories fukaya categories quantum invariants
Sexual adaptation across evolution: the neural basis of female sexual motivation (EvoSexDrive)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

What are the molecular mechanisms that determine intra- and inter-species behavioral variation? We propose to address this key outstanding question in evolutionary neuroscience by exploring a striking example of adaptive evolution of female sexual behavior. Comparing two closely related nematode species that use different mating strategies, we discovered that while androdioecious (hermaphrodite-male) C. elegans hermaphrodites are indifferent to males, dioecious (female-male) C. afra females exhibit a pronounced sex drive, actively engaging in and initiating mating. Importantly, we found that under induced reproductive pressure, the passive hermaphrodites switch to female-like behavior, suggesting the existence of a suppressed neuronal circuit. In this proposal, we will employ an evolutionary comparative approach to deconstruct the neural basis of female sexual motivation, by addressing three objectives: (1) Explore and quantify the extent and molecular basis of female sexual motivation in C. afra. (2) Characterize the neuronal underpinnings of sexual attraction, by mapping gene expression, connectivity, and network dynamics in females, and (3) Investigate how mating pressure promotes sexual adaptation in C. elegans hermaphrodites, by monitoring the evolving changes in genetics, epigenetics, and the neuromodulatory network in transition states from passive to active sexual behaviors. Our suggested program challenges long-held assumptions about the role of female sexual motivation, which despite its complexity remains understudied compared to male mating behaviors. Our unique approach, utilizing the power of C. elegans alongside tool building for investigating C. afra, will not only unveil the molecular mechanisms governing the emergence of novel female sexual behaviors but also create a blueprint for understanding their evolution.

Keywords: c elegans,neuropeptides,evolutionary neuroscience,sexual behavior,synaptic connectivity,synaptic labeling
Roots to Routes: tastes and traditions on the move in the Atlantic route (RTR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-16
End date: 2027-09-15
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

In an era of increasing international migration, understanding cultural dimensions is crucial for fostering mutual understanding and social cohesion. Roots to Routes (RTR) is a participatory action research on the West African Atlantic Route that investigates cultural representations and practices of migrants from West Africa to the Canary Islands, with a focus on food as a conveyor of identity and a ground for cultural encounter. Research on irregular migration to the Canary Islands has emphasized economic and political aspects, understating cultural elements. RTR addresses this gap by exploring cultural practices, especially food-related ones. Its objectives are: 1) gathering information through field research; 2) promoting participatory actions to involve local communities; 3) creating visual documentation; and 4) offering policy recommendations for the European reception system. RTR employs a multi-sited ethnographic approach, engaging migrants, local communities, and NGOs in Senegal, Southern Morocco, and the Canary Islands. This strategy allows for a nuanced examination of migrants' experiences and cultural transformations before and after their journey to Europe. Participatory actions include workshops and events centered on food and cultural exchange, while the visual component involves collecting and creating images and videos for dissemination. By examining the maintenance and transformation of cultural identity and food habits during migration, RTR offers insights into social integration dynamics and contributes to culturally informed policies, aligning with key EU migration and cultural diversity objectives. The project is timely given the ongoing humanitarian crisis associated with the Atlantic Route. RTR's innovative approach positions it to make significant contributions to both academic discourse and policy development in migration studies, ultimately fostering mutual cultural knowledge and promoting positive intercultural interactions.
Micro-Macro Secure Control of Infinite-Dimensional Transport Systems (C-NORA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Greece
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Although "transport" may imply different notions for different scientific fields, the feature of incorporation of interacting system components through which "information'' is propagated remains invariant. Biological transport systems is an example whose significance has become evident with the recent outbreak of COVID-19 spreading. Blood transport in cardiovascular systems falls also under this category. The urgent need of design of efficient/safe, epidemics spreading suppression and congested blood transport monitoring, strategies is apparent, considering the potential, significant socioeconomic impact. However, the continuum, spatiotemporally-varying nature of such interconnected systems, in addition to dynamic complexity and limited available control authority, hamper development of systematic feedback control design and analysis methodologies. C-NORA aims at introduction of a pioneering holistic framework for systematic, computationally tractable control design and analysis of large-scale, interacting, distributed parameter transport systems, which i) harmonizes control at micro-macro levels, ii) accounts in design for all essential dynamic phenomena, iii) compensates adverse effects of limited control authority in design, and iv) develops ad hoc tools for system-specific analysis. C-NORA new control design and analysis tools will be demonstrated in distributed parameter, epidemiological/cardiovascular transport systems and will be validated in numerical simulation. C-NORA high risk lies in unification and complexity of heterogenous, unexplored infinite-dimensional systems, whose treatment requires rethinking of fundamental control-theoretic tools. C-NORA high scientific gain lies in that, on the way of executing its key ideas, novel, interdisciplinary concepts and groundbreaking control/analysis methodologies will be introduced, while unprecedented research arenas will open for systems and control, transport, mathematicians, and systems biologists.

Keywords: control of delay systems control of partial differential equation pde systems
A comprehensive method for medium-term analysis and forecasting (CMAF) of global monthly prices of agricultural commodities (CMAF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 3
Project status: SIGNED

This is a proposal for a comprehensive methodology for medium-term analysis and forecasting (CMAF) of monthly global prices of agricultural commodities. The project will create a tool based on this methodology, which provides a detailed explanation of the forecasts and enables their complete interpretation. Integrating eight econometric and machine learning (ML) methods, CMAF will combine the joint effects of over 100 possible variables. In addition, it will consider the inclusion of additional potential explanators for specific needs or purposes. It will use different cross-validation techniques to avoid a priori research assumptions and realistically captures these complex relations. First, the learning process begins with comprehensive stationary and causality tests, which detect the nature of each possible variable and its suitability to serve as an explanatory factor in the changed agricultural commodities prices. Secondly, it performs a retrospective analysis while considering many variables from three different groups: market fundamentals, financial and climatic. Thirdly, it uses relative importance analysis to reduce the number of features and include only those most essential for an accurate agricultural commodities price forecasting performance. Lastly, it provides a detailed and intelligible visual interpretation of the results and the learning process in a straightforward manner to serve even those with no academic or financial background. CMAF will be easily trained using publicly available data and will be made available open source. It will also be adaptable and could be applied to forecast the prices of various agricultural commodities, irrespective of budget, language or other skills constraints. The outcome will be a powerful and broadly applicable tool that will promote understanding in the global food trade and thus enhance food security and social equity.

Keywords: food security,agricultural commodity trade,price forecasting,price analysis,interpretable machine learning
Advancing Crip Reproductive Justice: Understanding women with intellectual disabilities' experiences of reproductive control in Spain (CripRJ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-16
End date: 2026-04-15
Duration (months): 30.0
Total project cost (EUR): 228652.96
EU funding (EUR): 228652.96
Participants: 2
Project status: SIGNED

In 2020, Spain abolished the widely practised and legally permissible forced sterilisation of Spanish women with intellectual disabilities (WID), marking a new era of disability reproductive justice and bringing the medical and familial reproductive control of WID to the forefront of socio-political awareness. This project, Advancing Crip Reproductive Justice is the first anthropological investigation of their experiences and examines how the new legislation's 'promissory note of inclusion' regarding reproductive self-determination has made a difference in the lives of Spanish WID. It also explores what a future in which WID are supported to reproduce might look like. Working across disciplinary boundaries of medical anthropology, disability studies, and speculative fiction, the CripRJ study ultimately seeks to answer, what kinds of crip-repro futurities are possible when we start from a place in which disability is seen as productive and valuable, instead of as deficient and something to avoid at all costs?

Keywords: forced sterilisation,disabled women,reproductive justice movement,spain,intellectual disability,speculative fiction
Synaptic signatures: Understanding thalamocortical circuit specification and disease vulnerability (ThalamoLinkIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Sensory processing is frequently altered in disorders like autism, schizophrenia and bipolar disorder. Neuronal circuits from the thalamus to the primary somatosensory cortex (S1) play a critical role in sensory processing. Dysconnectivity of such circuits is implicated in disorders associated with sensory processing impairments. The posteromedial thalamic nucleus (POm) connects to intratelencephalic (IT) layer 5 (L5) pyramidal neurons (PNs) of S1, regulating somatosensory processing. The mechanisms regulating connectivity and function of the POm>IT L5 PN circuit remain unknown. Cell surface proteins (CSPs) drive circuit formation and specification. I hypothesize that a unique combination of CSPs orchestrate the structural and functional connectivity of this circuit, and can explain vulnerability to certain disorders. To understand the molecular mechanisms involved in POm>IT L5 PN connectivity in mice, I will first isolate POm>IT L5 PN synapses and characterize their molecular signature with mass spectrometry. Next, I will use these data and information from public databases on the genetics of neurodevelopmental disorders, to select 5 postsynaptic CSPs to further study. Using genome engineering, I will next knock-out the selected CSPs, one at a time, and analyze the impact on the structure and function of the circuit. Last, to deepen our mechanistic understanding of these proteins and gain insight to the downstream pathways, I will map changes in the molecular composition of these synapses. This project will allow us to study for the first time the molecular correlates of the functional specificity of this circuit and provide insight in the pathomechanisms of associated disorders. The experience of the de Wit lab in studying mechanisms of synapse function, the cutting-edge technologies provided by the host institute and my scientific background will enable me to push the boundaries of existing methods and achieve the highest possible quality in this project.

Keywords: thalamocortical circuit synaptic cell surface proteins pom intratelencephalic l5 pyramidal neurons neurodevelopmental and neuropsychiatric disorders
Learning the origins of temperature-sensivity in nervous systems (ThermoSensO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 185111.36
EU funding (EUR): 185111.36
Participants: 1
Project status: SIGNED

Temperature influences living organisms at all the levels, from the rates of biochemical reactions within their cells up to their overt behaviour. Being fundamental to the physiology, animals evolved nervous systems capable of sensing temperature influencing in turn the behaviour (e.g., shivering when it is too cold). Cnidarians (like jellyfishes or corals) represents the second phylum in the animal kingdom endowed with a nervous system. Despite the many advancements in the field of thermal neurobiology, whether cnidarians possess neurons able to sense temperature is currently unknown. Acquiring this information and learning the modality of temperature-sensing would shed a light on the functions of the nervous system of the last common ancestor of cnidarians and bilaterians. With ThermoSensO, the researcher wants to address this question studying the temperature sensitivity in Hydra magnipapillata and Nematostella vectensis, two related classes of cnidarians. The transparency of their body, the public availability of their genome, and their phylogenetic position, make the two species very attractive animal models for this task. By associating behavioural testing with in vivo calcium-imaging and electrophysiology during delivery of thermal stimuli, the researcher wants to detect and characterise temperature-sensitive neurons and their role in these organisms. One of the most powerful tools to understand Biology is the comparison between species (e.g., Darwinian evolution theory). By providing to the scientific community a means of comparison with investigations in bilaterians and probing such an unexplored ground, ThermoSensO would give a very strong impulse to the field of thermal neurobiology and to the study of early nervous systems.

Keywords: temperature sensing,cnidarians,evolution
Circular Systemic Solutions for Plastic, Packaging, Bio-Waste, and Water (CircSyst)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Spain,Sweden,Belgium,Slovenia,Greece,Finland,Hungary,Austria,United Kingdom
Call: Circular Cities and Regions Initiative (CCRI)’s circular systemic solutions (HORIZON-CL6-2023-CIRCBIO-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 11436673.75
EU funding (EUR): 10244330.61
Participants: 32
Project status: SIGNED

To contribute to catalyzing the transition towards a sustainable, circular economCircSyst, presents a series of shared Demonstration Experiences of new technological and societal adaptations to a Circular Economy involving 8 European regions: Valencia (SP), Maribor (SI), Flanders (BE), Gotland (SW), Paijat-Hame-Lahti (FI), Castila la Mancha (SP), Central Macedonia (EL), and Central and East Hungary (HU). The project focuses on three of the priority value chains of the Circular Economy Plan: Water Management, Biowaste, and Plastics and Packaging, as well as in the potential synergies among them. 4 Demonstrators are proposed developing and validating solutions for Water Management: 1 Reuse of industrial treated wastewater through on-demand treatment. 2 Agricultural industry and utilities uses for reclaimed urban water. 3 Smart wastewater management as a structural solution to water scarcity and floods in urban contexts. 4 Validation of a set of Integrated tools and methodologies for smart management of water symbiosis. In the Biowaste field the project will implement 2 Demonstrators dealing with waste from different sources and extracting valuable substances directly applicable in the other addressed value chains: 5 Flexible and intelligent biorefinery for the recovery of materials and components. 6 Valorisation routes of Food Industry Biowastes. In the Plastics and Packaging field, the project tackles main aspects of plastic waste management, including eco-design, cost-effective segregation, and recyclability: 7 Mechanical recycling of mPET. 8 Consumers engagement in plastics segregation 9 Food Packaging value chain redesign towards the substitution of plastics Work Packages on Communication & Dissemination, Knowledge Transfer, and Results Exploitation and Impact, are designed to ensure that that the results adequately reach key stakeholders in governments, private organizations, and civil society with the cooperation of the CCRI Coordination and Support Office.

Keywords: circular systemic solutions industrial symbiosis interregional cooperation water cycle,bio waste biopolymers,plastics packaging recycling,