Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A BREAKTHROUGH TECHNOLOGY DESIGNED TO PRESERVE SIGHT AND HALTING VISION LOSS ASSOCIATED WITH A RANGE OF RETINAL DISEASE BY PREVENTING THE DEATH OF KEY RETINAL CELLS . (SeaBeEYE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

I am the CEO and Cofounder of SeaBeLife, a French biotechnology company developing First-In-Class drugs to treat severe pathologies affecting our vital organs for which there are no effective treatments. We develop an innovative therapeutic approach protected by 4 patents and with a lead program to treat Acute Liver Failure and a second program to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells. We are developing a first-in-class drug based on a dual-targeted approach, capable of stopping directly and simultaneously two forms of regulated cell death pathways known to be involved in triggering of numerous acute and chronic pathologies and contributing to organ damage. Our molecule protects the cells, prevents tissue damage, and finally preserves and restores organ function. SeaBeLife is the only company worldwide developing such a therapeutic approach. Our molecule has a direct protective effect on cells and has the potential to prevent evolution to severe life-threatening form. We have already obtained very convincing in vivo results in several highly predictive models. Our molecules were tested on pharmacologically relevant murine models and have shown no toxicity and strong efficacy. SeaBeLife is composed of an experienced and complementary operational team managing by two women and supported by a scientific and strategic advisory board with scientific and medical experts of extensive expertise in drug development. We have already raised 4.3M€ to develop our technology and we are ready to bring our molecules to the clinic and validate its safety and efficacy. The main milestones over the next 2 years will be the production of compliant clinical batches and the realization of phase 1 and phase 2a clinical trials. The WomenTechEU award and funding will allow us to gain visibility as women entrepreneurs and also to take an important step in our pre-clinical development for eye diseases.

Keywords: retinal disease regulated necrosis small molecule retinal detachment dry age malucular degeneration
Molecular receptors enrich methylated and acetylated peptides for ultra-sensitive proteomics to explore the hidden modified proteome in disease (ENRICH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Spain,Colombia,Cuba,United States,Germany,Argentina,Canada
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 1557428.57
EU funding (EUR): 1545600.0
Participants: 11
Project status: SIGNED

Scientific studies indicate that inefficient epigenetic control is associated with a wide variety of non-communicable diseases (NCDs) like cancer, schizophrenia, and diabetes. Indeed, histone post translational modifications (PTMs) are crucial for many cellular processes including transcription and DNA repair. Thus, the ability to readily and reliably detect PTMs is crucial to better understand epigenetic processes and the complex functions of histone PTMs in human diseases. Mass spectrometry (MS) is the technique of choice to identify such modifications across the proteome. MS requires an enrichment step generally performed using antibodies, but these have several limitations such as high costs, batch-to-batch variability and data reproducibility. In a multidisciplinary effort ENRICH aims at developing new cost-effective, fast and efficient tools for the enrichment of post translationally modified proteins overcoming the current limitation. ENRICH will functionalize nanoparticles (NPs) with molecular receptors able to enrich PTM-containing peptides, derived from proteolytic digestion, for subsequent MS analysis. Concurrently, the ability and selectivity of the synthesized receptors and functionalized NPs will be evaluated via spectroscopic analyses. The ENRICH network gathers the expertise required to tackle this challenge. The consortium is composed of 9 high-level academic research groups from 2 different continents (Europe and America) and 2 highly innovative companies. By the seconding of 87 ERs/ERSs across Europe and worldwide, the aim is to capitalize on the consortium expertise in complementary fields such as chemical synthesis, spectroscopy, and proteomics. The network promotes an effective integrate training of researchers, boosting their career development, and promotes collaborations between the partners. The direct involvement of industries guarantees the timely exploitation of the results from research laboratories to innovative products.

Keywords: molecular recognition,macrocycles,multivalency,post translational modifications
Recycling of Lithium from Secondary Raw Materials and Further (RELiEF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Germany,Romania,Portugal,France,Finland,Netherlands
Call: Sustainable processing, refining and recycling of raw materials (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 6003240.75
EU funding (EUR): 6003240.0
Participants: 12
Project status: SIGNED

Current recycling technology is focused on recovering Li from battery scrap, while hardly much focus and technological development is going towards other Li sources. Hence the aim is to recover Li from potential secondary sources, in order to reduce unrecovered Li from its waste generation, which is estimated to be approx. 27.33% of the current global Li production. RELiEF proposes an integrated recycling facility for Li from secondary raw material sources with continuous processing to produce battery materials. Li wastes will be reduced by more than 70%, which will instead be recycled into high value battery-grade material. The results of the integrated and continuous process up to battery precursor recovery will be demonstrated at TRL 5 and battery active material closed-loop process will be demonstrated at TRL4 with a 1.5 – 2.5 kg/week output of battery active materials and a new business model will be developed for the materials acquisition and processing, taking into account environmental and social sustainability. The expected results will contribute to decreasing the dependency of the EU on imported battery chemicals and raw materials. RELiEF will greatly strengthen the EU’s competitiveness in the battery storage value chain. The RELiEF consortium consists of 12 partners, six of which are SMEs (ABEE, EXT, EURICE, IST, PEG, TC), four are non-profit RTOs (IMNR, INEGI, ZSW, NOVA) and further two are universities (LUT, ULB) and one associated industrial partner (LANX), Thus, it a very high amount of industry involvement, entirely in the form of innovative SMEs covering the technological and also the impact maximization related aspects of the project; a perfect combination of basic research methodologies, chemical process and analysis capabilities, technology development in an industrial environment and strong ties to the recycling and battery industry and policymaking entities inside the EU.

Keywords: secondary ore to battery,li recycling,direct recycling,selective recovery,business modeling
Integrating structure and statistics in language processing: an ecological neural dynamics and manifolds approach (DYNALANG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Language is a vital aspect of human life. Whether it is processed predominantly by its structure (grammar) or statistics (word probabilities) is a contention long debated in Psychology and Linguistics, reignited by the rise of statistics-based models like ChatGPT. Crucially, the brain preserves linguistic structure (speech sounds, grammar, pragmatics) while adapting to the statistics of a changing environment (new words, slang, diverse accents). Unraveling our ability to encode both structure and statistics is key to neurocomputational theories of language. Contemporary neuroscientific models excel at harnessing statistical properties of text, but overlook both linguistic structure and face-to-face language use— the source of the ‘true’ statistics the brain relies on. DYNALANG pioneers a new path for the neuroscience of language by using neural dynamics to integrate structure with ecologically-valid statistics. In contrast to existing approaches, it hypothesizes that structure and statistics support each other. It uses MEG and dual-EEG across four typologically-distinct languages and behaviors(listening, speaking, multimodal conversation) to discern the boundary conditions for integrating structure and statistics, forming the basis of innovative models reflecting the brain's statistical experience. DYNALANG harnesses neural dynamics, the intricate patterns in interconnected neuronal activity, as the brain's intrinsic computational method for information integration. DYNALANG develops manifold language models—latent spaces where neural and behavioral dynamics combine with linguistic annotations, whose dimensions and geometry isolate neural computations. DYNALANG will give unique insight into how speech and gesture form language in the brain, envisioning linguistic representation as dynamic rather than static. This will fundamentally change computational and neurobiological theories of language, impacting future brain-computer interfaces, clinical prostheses, and AI.

Keywords: linguistic structure,neural dynamics,computational modelling,naturalistic spoken language comprehension,speech production,multimodal language processing,meg,temporal response function,latent space,manifolds
G9 GO FOR THE MISSIONS! (G9MISSIONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 9
Project status: CLOSED

The G9 GO FOR THE MISSIONS (G9MISSIONS) will be our 3rd experience as a consortium in managing the European Researchers’ Night in Spain, covering 40% of the Spanish territory. University of Cantabria will be the coordinator of a team composed by eight Spanish universities acting as beneficiaries. The overall initiative will be centred on the five European research and innovation missions that aim to deliver solutions of the great societal challenges facing our world (climate-neutral and smart cities, adaptation to climate change, cancer and healthy soils and water). G9Missions will promote awareness and encourage them to find solutions together to make a real difference. Engaging activities will be designed to show the policies that are behind these missions, namely the European Green Deal, Europe’s Beating Cancer Plan as well as the Sustainable Development Goals. The project consists of two main events to be held on September 30th in 2022 and September 29th in 2023, three pre events open to general public, Researchers at school activities distributed throughout the two years focused on pupils in schools and two post events as wrap-up meetings to analyse the impact. Pre-events will be celebrated on World Environment Day (5th June), World Cancer Day (4th February) and World Oceans Day (8th June), each with a main activity coordinated by different partners. Researchers at school activities will be part of a programme denominated Circular Science based on activities with innovative methodology and involving the whole school community. A Mission Book and a school certification after completing all missions will be some assets to promote participation. STEM fields, RRI principles, gender management and Open science practices will be widely covered, The European dimension will be emphasised by the active involvement of researchers with European funds and Marie Skłodowska-Curie fellows and a strong collaboration with the European Universities initiatives.

Keywords: stem,missions,pupils,schools,challenges,gender,climate,cancer
Le' Colaz: Building an Adaptable Future Brick by Brick through A Comprehensive Framework for Circular, Secure, and AI-Optimized Sustainable Construction (Le Colaz)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Greece,Cyprus,Spain,United Kingdom,Belgium,Sweden,Netherlands,Italy,France,Norway
Call: Design for adaptability, re-use and deconstruction of buildings, in line with the principles of circular economy (Built4People Partnership) (HORIZON-CL5-2024-D4-02, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 3996920.0
EU funding (EUR): 3996920.0
Participants: 12
Project status: SIGNED

The Le’ Colaz system redefines construction and renovation by integrating innovative tools, products, and techniques to enable adaptable, circular, and sustainable building practices. Inspired by “LEGO bricks,” its modular framework combines bio-based and recycled materials with advanced snap-fit components, designed for seamless assembly, disassembly, and reuse. This approach significantly improves the adaptability of buildings and building units to new uses, ensuring optimal utilization of indoor spaces and enhancing living and working conditions. By embedding principles of circular economy and life-cycle optimization, Le’Colaz extends the service life of buildings and increases the reuse and recycling of building elements, reducing waste and resource consumption. The system incorporates two cutting-edge digital platforms: the Internet of Materials Module (IoM²), which uses IoT sensors and digital product passports to monitor component performance, enabling predictive maintenance and informed decisions on reuse or recycling, and the Internet of Building Brain (IoB²), powered by Large Language Models (LLMs), which optimizes renovations, regional component reuse, and compliance with regulatory frameworks. Together, these tools facilitate dynamic adaptations to changing user needs and environmental conditions while promoting best practices for design for adaptability, reuse, and deconstruction. The system’s effectiveness is validated through simulation-based assessments and Living Labs in Athens and Trondheim, demonstrating measurable gains in energy efficiency, circularity, and adaptability. By fostering awareness and innovation in sustainable construction, Le’ Colaz sets a new standard for circular, resource-efficient buildings. Through its modular design, digital intelligence, and life-cycle optimization, it delivers measurable improvements in adaptability and resource efficiency, paving the way for a circular and future-proof built environment.

Keywords: modular construction,circularity,sustainable buildings,bio based and recycled materials,snap fit assembly,digital twin,iot sensors,predictive maintenance,adaptive reuse,deconstruction
Cohesion in Particulate media (CohPa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2469604.0
EU funding (EUR): 2469604.0
Participants: 1
Project status: SIGNED

How grains flow? Can we predict the behavior of sand, snow, powders and more generally of a collection of particles? In many situations both in nature or industry, this question is of importance to predict avalanches, landslides, or designing silos and industrial processes. While for simple fluids the measure of the viscosity is sufficient to compute and predict the flow, for granular materials the question remains open. The challenge of understanding the physics of granular flows has motivated many researches and constitutive laws have been developed for grains interacting by friction and collision. However, in many applications, grains present cohesion and predicting their behavior is much more challenging. Sticky or humid grains, powders, snow, fibers are examples of granular media having difficulties to flow, with clogging, agglomeration, intermittency. The CohPa project aims at a fundamental understanding of the behavior of cohesive granular materials, by combining experimental, numerical and theoretical approaches, with the ultimate goal of developping constitutive laws able to predict their behavior in any configuration. The two work packages correspond to two types of cohesive materials. In WP1, I will study cohesion resulting from the presence of adhesive forces between particles and I will focus on the development of model materials made of sticky grains with tailored surface properties as well as on real powders. By developing innovative rheological technics coupled with numerical simulations we hope to get a new understanding of the rheology. In WP2, I will study the cohesion arising from entanglement between frictional particles, as observed in an assembly of fibers (as in a bird nest or a cotton ball), or when mixing fibers and grains (typically roots in soils). They constitute a new class of disordered materials, in which the tensile strength results from a subtle coupling between geometry, elasticity and friction, which is not yet understood.

Keywords: granular flows,rheology,entanglement
European Clean Aviation Regional Ecosystems (ECARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Coordination and support actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: France,Germany,Italy,Belgium
Call: Developing a European Clean Aviation Regional Ecosystem (ECARE) (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 720012.5
EU funding (EUR): 720012.5
Participants: 4
Project status: CLOSED

To reach Europe climate neutrality by 2050 as ambitioned by the Green Deal strategy, it is necessary to drastically reduce emissions from aviation. Clean Aviation Joint Undertaking has set out a very ambitious innovation programme to achieve this goal but it is also necessary to create synergy with the different aeronautical regional/national funding programmes in order to create leverage effects and maximise funding impact. ECARE project’s objective is to draw linkage between European/national/regional roadmaps and aeronautical stakeholders and co-create synergies through a pilot covering 4 major aeronautical European regions (Occitanie and Nouvelle Aquitaine in France, Hamburg Land in Germany and Campania in Italy) with the aim of creating a methodology expandable to other aeronautical European regions. ECARE digital platform will provide (i) a mapping of funding opportunities, relevant projects, scientific and industrial resources, (ii) a forum for exchange of information. The ECARE Stakeholders Group (funding bodies, clusters and other aeronautical stakeholders) will foster and spread ECARE methodology. After more than a hundred interviews with aviation players, national and transnational workshops will co-elaborate and provide recommendations for CAJU Phase 2 implementation by 2025. The consortium is composed of 3 major European aeronautical clusters (Aerospace Valley, Hamburg Aviation and Campania Aerospace District) and one Belgian SME specialized in aeronautics technology services (EASN-TIS). All are experts in their domain and other European aeronautical clusters will be involved inter alia via the EACP (European Aeronautical Clusters Partnership) partnership coordinated by Hamburg Aviation cluster. Eventually the project is expected to bring together more than 300 entities via the platform and 30 ECARE Stakeholders Group members that will collaborate on the synergy to help the European aviation achieve its ambitious goals.

Keywords: aeronautics innovation synergy ris3 clusters fundings