Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Conservation genomics of endangered green sea turtles (SeaTGen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-22
End date: 2023-09-08
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

Conservation and management of marine turtle populations are challenging because of their complex life history involving long-distance migrations. Consequently, marine turtles are affected by a wide range of anthropogenic threats across temporal and spatial scales, including climate change. The cumulative effect of these impacts is likely to have direct and indirect implications on these endangered species in the near future. This project aims to refine our understanding of the spatial structure of green turtles (Chelonia mydas) in the South-West Indian Ocean to understand better how populations interact and how they may be impacted by threats both at the nesting ground, at distant foraging areas, and along migratory corridors. To do so we aim to apply the power of genome-wide Single Nucleotide Polymorphisms (SNPs) combined with traditional mtDNA markers to assess fine-scale population structure and recent demographic history. In addition, the research will take a multidisciplinary approach, combining novel genetic methods with data from movement ecology (satellite telemetry) and oceanography (ocean current modelling) to provide a comprehensive analysis of connectivity between breeding and foraging areas. The results will allow conservation managers and policymakers to identify areas in need of protection and to assess the potential impacts of anthropogenic activities such as marine turtle interaction with fisheries. As such, our results will provide the scientific basis for future conservation actions within the framework of Integrated Maritime Policy. This project will allow me to gain critical new skills in conservation genomics. This will broaden my research horizon, strengthen my research profile and place me in a strong position for furthering my research career within the European Community.

Keywords: marine turtles,sea turtles,chelonia mydas,radseq,snps,assignment analysis,indian ocean
Targeting cancer vulnerabilities in acute leukemia (ONCODESTROYER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 3200000.0
EU funding (EUR): 3200000.0
Participants: 1
Project status: SIGNED

Background and rationale: Adult acute leukemias pose a great challenge to cancer therapy, with only few advances made in 50 years. As these malignancies are commonly associated with multiple epigenetic aberrations, epigenetic factors represent attractive leukemia drug targets. Nevertheless, most epigenetic-targeting drugs have displayed limited clinical benefit and key leukemia drivers like MYC, ERG and MYB remained mostly undruggable. We have developed a new class of small molecule kinase inhibitors, termed “oncodestroyers” (ODs), single molecules combining supreme p53 activation with selective disruption of multiple leukemia-specific super-enhancers (SEs) that drive oncogenes and dependency/vulnerability factors. These inhibitors demonstrate an unprecedented therapeutic potency in mouse models of human leukemia and are entering now leukemia clinical trials. With this project we wish to study the principles of “oncodestruction”, mechanisms of drug action, immune system interface, and preempt drug resistance. Relevant knowledge may be applied to other cancer diseases, sharing vulnerabilities with leukemia. Major Goal: To expand the therapeutic potential of ODs in leukemia and pre-leukemia by studying their vulnerability basis, mechanisms of drug action and indicators of therapeutic response in individual patients. Research plan: 1) Expand the collection of small molecule kinase inhibitor ODs and develop OD-based PROTACs to gain an optimal spectrum of kinase targets with good therapeutic window in AML; 2) Elucidate the mechanisms of action and what distinguishes an OD, with emphasis on SE disruption, p53 activation and OD-immune-cooperation; 3) Explore the translational aspects of OD treatment by: identifying OD resistance and relapse mechanisms; study clonal evolution in MDS and AML patients undergoing phase 1a/b clinical trial; predict a patient response to ODs and use ODs for ameliorating age-related clonal hematopoiesis, thus possibly averting leukemogenesis.

Keywords: drug development,kinase inhibitors,drug resistance,imaging drug response,drug immune cooperation,transcriptional addiction,clonal evolution of cancer,age related clonal hematopoiesis
CONFINED CATALYSIS IN LAYERED MATERIALS – A TRANSFORMATIONAL APPROACH FOR EFFICIENT WATER SPLITTING (CoCaWS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-07-02
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Sustainable solution for global energy crisis is firmly associated with seeking energy sources other than fossil fuel. In this respect, the production of hydrogen through water splitting (WS) has been regarded as the greenest approach to power the globe. At present, the issue of realizing active and stable material capable of catalyzing WS in all pH ranges is unsolved. CoCaWS aims at exploring new efficient catalysts for overall WS to tackle the problem of global energy crisis through ecofriendly hydrogen production. I hereby propose to study a new class of efficient catalysts based on composite two dimensional (2D) layered nanomaterials. I employ the concept of confined catalysis, catalytic activities taking place in a unique nanoscale environment partitioned from the surrounding bulk space, to ensure long term efficient production of H2 from water. The van der Waals (vdW) gaps between the layers will serve as a suitable platform to confine another active species. Through this approach, I aim at solving the most critical problems in the field such as catalytic functionality in neutral media for metals or alloys and poor basal plane activity in layered 2D materials. I will make use of the most conducive research environment in UNIVE to acquire new skill/knowledge and broaden my basic knowledge on advanced characterization techniques and data interpretations. The knowledge of physical chemistry, material science, condensed mater physics, and computational chemists will be involved to confront with the complexity of the task through smooth interaction with researchers in the Department of Molecular Sciences and Nanosystems of UNIVE. The project, up on completion, will provide a significant stepping-stone in the quest for responding the escalating demand of greenest energy source. I will make every possible effort to disseminate/communicate the outcomes of CoCaWS to broad audiences ranging from schoolchildren to researchers.

Keywords: water splitting,layered materials,van der waals gap,confined catalysis
Couples' experience and need for medical care and psychosocial support during pregnancy after prior pregnancy loss (PREGAFTERPL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-16
End date: 2023-08-15
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Pregnancy loss (PL) occurs frequently and has negative psychological effects on women and their partners. Medical treatment after a PL is focused on emptying the uterus with no attention to psychological needs. There is limited knowledge on how to prevent and reduce the negative mental health consequences of PL, especially how to cope with the stress and anxiety during a subsequent pregnancy. Given a 25% PL rate, it stands to reason a number of pregnant women and partners may be vulnerable given their reproductive history. Interventions to support couples during a pregnancy after PL are non-existent. The proposed project aims to better understand couples’ experience and needs during a pregnancy after PL using repeated qualitative interviews. This form of data collection is ideal given pregnancy is a process where desires and needs can change over time. Couples with prior PL will be interviewed four times during their pregnancy (i.e., after positive pregnancy test and once in each trimester). The findings will inform the development of: a) recommendations to medical professionals on how to enhance the quality of health care during pregnancy after PL based on couples’ accounts of their experiences and needs across a pregnancy; b) an intervention in cooperation with the target group to increase couples’ knowledge of what to expect and how to cope during pregnancy after PL. I will significantly benefit from a placement at the University of Copenhagen, Department of Public Health, which houses the Copenhagen Pregnancy Loss Research Programme; an international, interdisciplinary research group that aims to reduce the negative impact of PL on physical and mental health and improve clinical practice related to PL. The proposed project will contribute key psychological and clinical insights not currently represented in the host group, whilst diversifying my competency into the public health and intervention development fields in which I will focus my future career.

Keywords: qualitative research,mental health,public health,reproductive health,pregnancy loss,pregnancy,fertility
Hybrid coupled networks for thermal-electric integrated smart energy Districts (HYPERGRYD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Austria,Italy,Italy,Austria,Austria,Germany,Germany,Germany,Spain,Italy,Austria,Sweden,Belgium,Poland,United Kingdom
Call: Innovative land-based and offshore renewable energy technologies and their integration into the energy system (H2020-LC-GD-2020-1, 2020)
Start date: 2021-10-01
End date: 2025-03-31
Duration (months): 42.0
Total project cost (EUR): 5987875.0
EU funding (EUR): 5987874.5
Participants: 20
Project status: SIGNED

HYPERGRYD aims at developing a set of replicable and scalable cost effective technical solutions to allow the integration of RES with different dispatchability and intrinsic variability inside Thermal Grids as well as their link with the Electrical Grids, including the development of innovative key components, in parallel with innovative and integrated ICT services formed by a scalable suite of tools for the proper handling of the increased complexity of the systems from building to Local Energy Community (LEC) levels and beyond, accelerate the sustainable transformation, planning and modernization of District Heating and Cooling (DHC) toward 4th and 5th generation. HYPERGRYD also aims at developing real time management of both electrical and thermal energy flows in the coupled energy network complex, including the synergies between them. Therefore, HYPERGRYD aims at three over-arching General Objectives: - To prove Smart Energy Networks as the future of Efficient Energy Management in DHC in synergy with the Electrical Grids in LEC/Smart Cities of the future, - To define the roadmap to design and planning of future DHC as well as the modernization of the existing ones in different climates and RES penetration levels toward 4th-5th generation, -To demonstrate HYPERGRYD RES-based Enabling Technologies, Smart Energy Grid Solutions empowered by new ICT tools and services as the key for this evolution. During the project, the HYPERGRYD?s solutions will be implemented across 4 Live-In-the-Labs cases in 3 representative climates provided by the consortium, with special consideration to their cost effectiveness and potential replicability to finally achieve these 3 main objectives. All these tasks will follow the proposed work program activities to ensure systematic and scientific performance measures, feedback and powerful exploitation.
Re-use of Thermoplastic Composite (RESET)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,France
Call: Eco Design for Airframe - Re-use of Thermoplastics Composites (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2018-04-30
Duration (months): 28.0
Total project cost (EUR): 349156.25
EU funding (EUR): 325006.25
Participants: 2
Project status: CLOSED

Current European policies plead for new technologies capable to implement feasible processes for recycling of products in their end of life cycle. Within this framework the re-use of thermoplastic composites, is a recurrent topic within the aircraft manufacturing industry which needs a suitable solution for the high performance thermoplastic composites once the craft is dismantled. PEEK (Polyether ether ketone) and PPS (Polyphenylene sulphide) all together reinforced with CF (Carbon Fibre) and, are the most common high performance materials considered as leftovers when their lifecycle has come to an end . Taking this into account, the RESET project aims to bring a second life to those thermoplastic composites which have been condemned to landfills, to the carbon fibre recovery by means of polymer pyrolysis or to energetic recovery. This milestone will be achieved through a sorting and milling process of these materials, leading to short chopped fibre reinforced thermoplastic granulates. These conditioned leftovers will be subsequently used to obtain new reinforced thermoplastic composites, by melt compounding along with virgin polymer, considering both monocomponent as well as binary blends. Besides, an evaluation of the properties of recycled materials will be carried out in terms of repeatability, processability and final product properties in order to ensure the suitability of the products regarding the final application of the demonstrators (e.g, brackets, clips...). With that purpose, process parameters will be defined during the design and evaluation of the prototypes mould. Summing up, the RESET project will lead to a whole new family of rCFRP reducing, therefore, the environmental footprint by giving a second life to the waste, by means of recycled high value products within the aircraft manufacturing value chain, redounding in the aerospacial economy through a closed-loop cycle philosophy.

Keywords: recycling,composite parts,cfrps,thermoplastics
High Technology, Energy and Water saving integrated hydraulic control valve for all purpose with 40% reduction in head losses (TECOOVAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Israel
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OOVAL develops, manufactures and markets hydraulic control valves for irrigation, water networks, fire extinguishing systems, and industrial manufacturing applications. As an Israeli company we excel in dealing with the water scarcity problem, being a world leader country increasing the efficiency of water management . Water losses in municipalities and industry, also called Non-Revenue Water (NRW), are largely attributed (up to 50%) to pipes faults such as leaks and bursts. The total loss of NRW worldwide is €10.2 billion according to the World Bank estimations. Each year more than 32 billion m3 of treated water are lost through leakage from distribution networks. Pressure control is an effective way to reduce such burst and leakage in water distribution systems. We have developed TECOVAL, the first hydraulic all-purpose control valve allowing pressure control with 40% head loss reduction. The objective of the project is the industrial development (from TRL6 to TRL9) of a range of control valves (8” to 16”) that includes: • the TECOVAL mechanical part already developed. • the integration of the electronic system (ALL-IN-ONE) for full management control of the water network. TECOVAL feasibility study objectives are: to verify the feasibility of the different system components (electrical and mechanical) integration, identify system design modifications based on different standards (ISO, ANSI, DIN, JIS) per country and industry; searching component suppliers, distributors and subcontractors for further industrialisation; and establishing the commercial profit. The outcome will be a business plan which will provide important information for the industrial deployment and commercialization of TECOVAL with a guarantee of success.

Keywords: hydraulic valves,water saving
Mechano-regulation of neural crest cell differentiation. (CREST UNDER TENSION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: TERMINATED

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair. The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.

Keywords: developmental biology,cell biology,mechanotransduction,neural crest cells
The role of novel opsins in non-visual light detection in the zebrafish brain (ZNEOPSIN_II)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-03-17
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Light impacts on life by modulating the physiology and behaviour of most living organisms. Both vertebrates and invertebrates have developed an extensive and diverse range of photoreceptor structures and photopigments, which mediate these light responses. Clearly light is used for vision, being detected by specialized rod and cone cells in the retina and processed by the visual centers of the brain. However, light also regulates many non-visual processes, and novel nonvisual photopigments are regularly being discovered. Recent studies have shown a role for non-visual photoreception in seasonal responses, activation of DNA repair mechanisms, entrainment of the circadian clock and sleep-wake regulation, but the mechanisms are far less understood. This phenomenon is particularly extensive in teleosts such as zebrafish, where all tissues and cells of the adult and larval body are directly light responsive. The purpose of ZNEOPSIN_II is to determine the role that non-visual light detection plays in early development in zebrafish, focusing on neurobiology, the entrainment of the circadian clock and specific aspects of behaviour. I will take advantage of zebrafish, a genetic model organism available at the host lab, a leading zebrafish circadian biology lab at University College London, which is also one of the larger zebrafish research communities in Europe. The latest technical approaches for gene knockdown (CRISPR/Cas genome editing), and luminescent/fluorescent imaging, together with classical molecular biology techniques, will be combined with state of the art behavioural assays developed in zebrafish. The results of ZNEOPSIN_II will provide invaluable insights into the biological significance of non-visual light detection, and the roles played by a range of newly discovered opsins, as well as provide a junior researcher with the best possible training in both molecular biology, functional neurobiology and behaviour.

Keywords: photopigments,zebrafish,circadian entrainment,gene expression,opsin,behaviour