Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deep-Sea Mining on Continental Shelves: Environmental Stakes and Clash of Interests on the High Seas (ARCTICMINER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 267418.56
EU funding (EUR): 267418.56
Participants: 1
Project status: SIGNED

ARCTICMINER addresses a knowledge gap on the protection of the marine environment during the deep-sea mining on continental shelves. In 2024, Norway opened 280,000 km² of its Arctic continental shelf (CS) for mineral exploration, making it one of the first coastal states to pursue such activities. These endeavors have direct significance to the EU due to the risks of biodiversity loss, pollution, releasing methane, and potential adverse effects on EU fisheries. The main objective of ARCTICMINER is to assess how deep-sea mining on CS aligns with international obligations of coastal states, particularly under the United Nations Convention on the Law of the Sea and the newly adopted Biodiversity Beyond National Jurisdiction Agreement (BBNJ). The project also explores how coastal states' sovereign rights to engage in deep-sea mining can be balanced with the rights of the international community. The project will test two hypotheses: first, whether recent developments in international law require adjustments in coastal states’ practice; and second, to what extent the rights of coastal states can be limited by obligations not to infringe upon high seas freedoms and the common concern of humankind in conserving biodiversity. ARCTICMINER will use doctrinal and law in context methods to analyze coastal states’ obligations, placing the analysis in the context of new developments, such as BBNJ, protection of rights of future generations, and rights of nature. The project will generate policy recommendations, potentially influencing states’ policies related to deep-sea mining. ARCTICMINER will also use case-study approach to analyze Norway's practice. The novelty of ARCTICMINER lies in its focus on an emerging issue of deep-sea mining on CS and its integration of the newly adopted BBNJ Agreement into the analysis. The project aims to contribute to more sustainable ocean management, aligning with the objectives of the MSCA Work Programme and the EU Green Deal.

Keywords: deep sea mining,continental shelf,environmental protection,marine environment,arctic
Geometry and analysis for (G,X)-structures and their deformation spaces (GENERATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1676870.0
EU funding (EUR): 1676870.0
Participants: 2
Project status: SIGNED

The study of geometric structures on manifolds finds its inspiration in Klein’s Erlangen Program from 1872, and has seen spectacular developments and applications in geometric topology since the work of Thurston at the end of the 20th century. Geometric structures lie at the crossroads of several disciplines, such as differential and algebraic geometry, low-dimensional topology, representation theory, number theory, real and complex analysis, which makes the subject extremely rich and fascinating. In the context of geometric structures of pseudo-Riemannian type, the study of submanifolds with special curvature conditions has been very effective and led to some fundamental questions, such as the open conjectures of Andrews and Thurston from the 2000s, and the recently settled Labourie’s Conjecture. This project aims to obtain important results in this direction, towards four interconnected goals: 1. the study of quasi-Fuchsian hyperbolic manifolds, in particular leading to the proof of a strong statement that would imply the solution of the conjectures of Andrews and Thurston; 2. the achievement of curvature estimates of L^2-type on surfaces in Anti-de Sitter space; 3. the construction of metrics of (para)-hyperKähler type on deformation spaces of (G,X)-structures, and the investigation of their properties; 4. the study of existence and uniqueness of special submanifolds of dimension greater than 2 in pseudo-Riemannian symmetric spaces. The project adopts an innovative approach integrating geometric and analytic techniques, and the results will have remarkable applications for Teichmüller theory and Anosov representations. In the long term, the proposed methodology and the expected results will lead to further developments in various related directions, for instance: the study of pseudo-Riemannian manifolds of variable negative curvature, of higher dimensional pseudo-hyperbolic manifolds, and the deformation spaces of other types of (G,X)-structures.

Keywords: geometric topology,g,x structures,pseudo riemannian geometry,minimal and maximal submanifolds,hyperbolic geometry,anti de sitter geometry,quasi fuchsian manifolds,deformation spaces,teichm ller theory,geometric analysis
Re-Constructing Sentencing: A Multidimensional Study of Judicial Discretion in Continental Europe (RE-CON-SENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Czechia,Finland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499975.0
EU funding (EUR): 1499975.0
Participants: 2
Project status: SIGNED

Consistent sentencing is a cornerstone of modern rule-of-law criminal justice systems. To enable judges to consider diverse circumstances at sentencing, legal frameworks provide judges with discretion (some countries also supply guidelines to increase consistency). The challenge is to provide judges with the right amount of discretion and guidance. This can be done in various ways, but there has not yet been any comprehensive assessment of these or of the limits they set across continental Europe. Attempts to evaluate the disparity of judicial practices run into the difficulty of identifying comparable cases. Typical sentencing studies consider behaviours to be the same if they fall within the same legal offence definition. However, each offence encompasses a wide range of behaviours, which impedes proper identification of disparities. This project will redefine our understanding of sentencing discretion and its application by making a complex assessment of discretion within three dimensions: legal frameworks, judicial practices, and guidelines. I will analyse and classify approaches to structuring discretion in every European continental legal framework and quantify their discretion and punitivity. I will combine innovative data and methods – thorough court descriptions of criminal behaviour and natural language processing – with detailed administrative data to examine sentencing practices in two similar, yet also different countries: Finland and Czechia. I will design European guidelines for a single jurisdiction currently not employing them and experimentally evaluate their overall effectiveness, mechanisms and punitivity. By deconstructing sentencing along these three dimensions and examining each in detail, I will paint a holistic picture of sentencing discretion, its extent, how it is structured across Europe, and its impact on punitiveness. The project will open multiple new research pathways and counterbalance the prevailing common-law-centric discourse.

Keywords: sentencing courts punishment discretion disparity guidelines
A disruptive tool for rapid, reliable and affordable Total Viable Count detection in filterable samples (MICA-TVC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Microbiological quality control (MQC) is crucial across various industries, including pharmaceuticals, food and beverages, ensuring product safety and compliance with stringent regulatory standards. Traditional culture-based methods, essential for determining Total Viable Count (TVC), remain the gold standard due to their reliability and regulatory acceptance. However, these methods are labor-intensive, time-consuming, and prone to inefficiencies and human error, leading to operational disruptions, financial losses, and reputational damage. Alternative Rapid Microbial Methods (RMMs) promise faster results but struggle to accurately determine TVC and differentiate between live, dead, and non-culturable cells. Their lower accuracy and the high prevalence of non-culturable microorganisms complicate their regulatory acceptance, hindering their adoption and implementation. DIAMIDEX addresses these challenges with MICA (MIcrocolony Counter Automatic) technology, an array of cutting-edge solutions to provide rapid, accurate, and cost-effective microbial detection and enumeration. MICA technology enables detection at the microcolony stage, before microorganisms are visible to the naked eye. The EICA project aims to improve our MICA solution for TVC detection in water samples to be deployed in the water and beverage industry. Our MICA-TVC provides 2x faster results than culture-based methods, 2x cheaper than RMM, while ensuring compliance with regulatory standards. MICA-TVC will offer a transformative solution for microbiological analysis labs, providing a cost-effective, streamlined approach for faster product release. This innovative technology promises to revolutionize MQC across various industries, ensuring safety, efficiency, and regulatory compliance.

Keywords: total viable count tvc,bioburden,culture based methods,microorganisms,rapid microbial methods,microbiological quality control
iMM-CARE: BOOSTING CLINICAL RESEARCH FOR THE BENEFIT OF SOCIETY (iMM-CARE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Portugal
Call: Teaming for Excellence (HORIZON-WIDERA-2022-ACCESS-01-two-stage, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 15000000.0
EU funding (EUR): 15000000.0
Participants: 3
Project status: SIGNED

iMM-CARE will deliver a pioneering Centre of Excellence (CoE) in human-centred clinical and translational research in Portugal by teaming up Instituto de Medicina Molecular João Lobo Antunes (iMM) with Vall d'Hebron Barcelona Hospital Institute of Research (VHIR). Having VHIR as a role model and strategic partner will create the framework and actions to have the best health care and research on a single campus – the Lisbon Academic Medical Centre (CAML) - catalysing a virtuous continuum across all stages of biomedical research, from bench to bedside and back again. iMM-CARE will develop and promote excellence in clinical and translational research, profoundly transforming how clinical and translational research is conceptualized, planned and implemented to deliver effective solutions to the most pressing health needs. The CoE will have at its core a mission-driven, human-centred, data-driven research and innovation (R&I) model as a new way to engage all stakeholders – citizens, patients, healthcare professionals, scientists, entrepreneurs, industry, health authorities and government – in interdisciplinary, cross-sectoral collaborations to solve health challenges. An articulated set of coordination and support actions will be driven by disease-specific missions, place people (citizens and patients) at the core of the R&I process, and leverage the power of new digital technologies and data to accelerate the path of R&I in broad collaborative efforts across the healthcare value chain. The broad collaborative efforts will follow the quadruple helix approach, use open innovation and open science methods to develop and enhance R&I capacities and projects to facilitate a rapid uptake of advanced technologies and solutions by healthcare systems at national and international levels. The upgraded CoE will act as a lighthouse and role model driving structural changes leading to a modernised and more competitive biomedical and health R&I system in Portugal and the EU.

Keywords: clinical and translational research human centred research digital transition training health open innovation quadruple helix co design co creation open science citizen science randi system
ADC for Pancreatic cancer (AB_ADC_CA04)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2766286.0
EU funding (EUR): 2766286.0
Participants: 1
Project status: SIGNED

Monoclonal Antibody and ADC against solid tumors. Despite advances in cancer treatments, the disease remains largely incurable and cases are expected to increase significantly in the coming decades. By 2040, global cancer cases are projected to increase by 47-55%, reaching around 28-30 million. In Europe, new cancer diagnoses are expected to increase by 21% by 2040, driven by an ageing population, and mortality rates are projected to rise by 32%. This highlights the urgent need for more effective cancer prevention and treatment strategies. Pancreatic cancer is particularly severe, with a 5-year survival rate of just 2.9% for metastatic cases, and cases are expected to increase by almost 38,000 by 2040. However, the costly and lengthy drug development process can benefit from AI, which offers a way to accelerate the creation of more targeted and effective therapies. CancerAppy is a biotechnology company specializing in the discovery and development of artificial intelligence-based cancer drugs, aiming to create innovative and more effective treatments with fewer side effects. With a research team with over 20 years of experience, the company has built a pipeline of promising cancer therapies. The most advanced project is an antibody-drug conjugate (ADC) targeting pancreatic cancer, with proof-of-concept studies showing complete tumor remission after 21 days of treatment. In addition to this ADC, CancerAppy is developing other therapeutic candidates, including a TEAD inhibitor, a PARP inhibitor, and PROTAC for breast cancer. By connecting with research centres and KOLs around the world, Cancerappy is able to identify and validate new drug targets. The company’s business model focuses on licensing potential new drugs with minimal competition, aiming for stable revenues through upfront payments and royalties. With a robust AI platform and promising preclinical results, the company is well positioned to lead innovation in cancer therapies.

Keywords: adc for pancreatic cancer
Harnessing Specialized Metabolism from Anaerobes (AnoxyGen)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499859.0
EU funding (EUR): 2499859.0
Participants: 1
Project status: SIGNED

Anaerobic bacteria, a group of microorganisms that thrive in the absence of oxygen, have a significant impact on the quality of life on Earth. They play a crucial role in biotechnology and are essential components of the gut microbiota. As such, they are of tremendous importance for human, animal, and environmental health. On the other hand, certain anaerobes can be life-threatening pathogens. In light of this, there is an urgent need for a deeper understanding of the specialized metabolites of anaerobes, which could function as chemical mediators, virulence factors, and antibiotics. Although genome analyses indicate that anaerobic bacteria hold an enormous potential for producing structurally unique compounds, biosynthetic gene clusters are typically downregulated or silent under laboratory conditions. Synthetic biology approaches to unearth these cryptic pathways have been hampered by the lack of universal activation strategies, the cumbersome genetic tractability of anaerobes, and the incompatibility of standard expression systems with the oxygen-sensitive biosynthetic enzymes. The AnoxyGen project seeks to unearth the vast structural wealth of natural products from the anaerobic world and leverage their unique biosynthetic machinery using a highly versatile anaerobic expression platform. This ambitious initiative comprises four work packages aimed at refining synthetic biology tools, creating gain-of-function anaerobes, discovering novel drug candidates and virulence factors, and engineering biosynthetic pathways to create metabolic diversity. By achieving these objectives, AnoxyGen will grant a comprehensive overview on specialized metabolites and biocatalysts of anaerobes, which have great translational value for medicine, ecology, and biotechnology. In addition to providing valuable methods and tools to the scientific community, this project has the potential to bring significant benefits for the health and well-being of people, animals, and the environment.

Keywords: natural products,biosynthesis,antibiotics,polyketides,peptides,bacteria
Energy efficiency Building Enhancement through performance guarantee Tools (EBENTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Spain,Greece,Estonia,Austria,Slovenia,United Kingdom,Netherlands
Call: Demonstrating integrated technology solutions for buildings with performance guarantees (Built4People) (HORIZON-CL5-2021-D4-02, 2021)
Start date: 2022-10-01
End date: 2026-06-30
Duration (months): 45.0
Total project cost (EUR): 5605687.5
EU funding (EUR): 4785562.5
Participants: 11
Project status: SIGNED

EBENTO is aiming to develop an integrated platform for all actors involved in building and renovation sector to provide one-stop-shop to better coordinate and manage Energy Performance Contracting, bringing together the needs from all actors involved in enhancing the building stock. Through EBENTO, citizens will increase their implication in building energy efficiency enhancement, and both public institutions and energy communities will be able to identify potential energy efficiency improvements in residential housing stock, with SMEs and ESCOs support. Furthermore, with EBENTO platform, new business models for optimizing the financial (and, indirectly, other) resources available will be validated: • EBENTO will explore the best financing and collaboration schemes to set up energy services. • EBENTO will study how to enhance current Energy Performance Contracting (EPC) for Demand Side Mechanism (DSM) services and what kind of investment options (grants, loans…) can be implemented to increase the number and impact of energy efficiency projects in the city/region • By using digital tools, EBENTO will gather data from EPCs, financial schemes and energy savings to give to the citizens the required trust for investing in new solutions, and to companies the relevant information to reduce costs and easily replicate the work developed. EBENTO will ensure the exchange of relevant information between the different actors, making the renovation process cost-efficient and easy to operate and replicate. The platform will collect data related to performance contracts and guarantees, devices monitoring, energy savings, building information modelling, users’ opinions and comfort levels, among others.

Keywords: renovation,energy efficiency,one stop shop,energy performance contracting,business models,public institution,citizens,energy cooperatives,sme,esco
Acoustic fLow InteractioN over sound absorbing surfaces: effects on ImpedaNce and draG (LINING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1499125.0
EU funding (EUR): 1499069.0
Participants: 1
Project status: SIGNED

The lack of fundamental knowledge of the interaction between an acoustic wave and a turbulent boundary layer grazing an acoustically treated surface, such as an acoustic liner, is the cause of unexpected and unphysical results found when performing the acoustic characterization of the sound absorbing surface with inverse eduction methods. This is because, in this field, acoustic and aerodynamic have never been fully coupled. To fill this knowledge gap, the acoustic and hydrodynamic velocities near an acoustically treated surface must be measured. Since it cannot be done only with state-of-the-art experiments, because of hardware and field-of-view limitations, I propose to complement experiments with scale-resolved high-fidelity numerical simulations based on the lattice-Boltzmann very-large-eddy simulation method. Numerical results will be used to explain the physics of the acoustic-flow interaction. Advanced data analysis methodologies will be developed and applied to separate the acoustic-induced velocity near the wall from the hydrodynamic one. At the same time, the numerical database will be used to compare inverse methods, employed to acoustically characterize the sound absorbing surfaces, in order to explain the physical reasons behind the unexpected results, and propose physics-based corrections. Furthermore, by describing the flow-acoustic interaction, it will be possible to model and predict the drag increase caused by the coupling between the acoustic-induced velocity and the free-stream one. My description of the flow-acoustic interaction will solve the scientific debate about the unexpected results and pave the way towards future broadband low-noise low-drag acoustic meta-surfaces to increase propulsion efficiency and reduce noise of future, more sustainable, aircraft engines.

Keywords: aeroacoustics,impedance,flow acoustic interaction