Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the cellular and molecular divergence of the human cerebellum (hCerebEvol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1499958.0
EU funding (EUR): 1499958.0
Participants: 1
Project status: SIGNED

Speciation involves the emergence of new behavioural features that rely on the evolution of neural circuits. The human species displays higher cognitive features which have been linked in part to the evolution of the cerebral cortex, but the involvement of the other brain regions, such as the cerebellum, remains largely unexplored. The human cerebellum displays divergent features at the anatomical, functional, and behavioural levels. It is associated with both higher cognitive functions and cognitive disorders. However, the properties of human cerebellar cells & circuits have not been compared with those of other species, including non-human primates. This knowledge gap hinders our understanding of human brain evolution. Here, I aim to identify and functionally study the impact of human genomic novelties on cerebellum development and function, focusing on neuronal and & circuit levels. I will first investigate the role of a novel human molecular pathway in the cerebellum, based on the hominid transmembrane receptor family LRRC37, which I have recently identified. I will identify the cellular distribution, molecular partners, and function of LRRC37 receptors in cerebellar neurons using three approaches: cross-species tissue comparison, gain-of-function in vivo in the mouse cerebellum, and human models based on pluripotent stem cells. In parallel, I will identify new molecular novelties acting in human cerebellar cells, focusing on human gene duplicates and differentially expressed genes, and link them to divergent cerebellar properties. I will define the spatio-temporal expression patterns of these genes, followed by gain/loss-of-function in the mouse cerebellum and in human cerebellar neurons to study their function. Together, hCerebEvol will uncover entirely new aspects of human cerebellar evolution that will improve our understanding of brain development and function, and may lead to the identification of human-specific sensitivity to brain disorders.

Keywords: human brain evolution,cerebellum,duplicated genes,neuronal evolution,lrrc37
AcTivate and TRigger ACTors to deepen the function of Innovation Support Services (ATTRACTISS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Austria,Poland,Netherlands,Greece,Spain,Portugal,Hungary,France,Finland,United Kingdom,Germany
Call: Deepening the functioning of innovation support (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-10-01
End date: 2028-09-30
Duration (months): 72.0
Total project cost (EUR): 4657726.25
EU funding (EUR): 4657724.75
Participants: 17
Project status: SIGNED

The objective of ATTRACTISS is to improve & embed competencies, approaches, instruments & governance models for Member States (MS) AKIS and specifically for Innovation Support Services (ISS) as a crucial AKIS actor, to enable them accelerating individual grassroots innovative ideas to come to fruition & to generate solutions for the transition process to more sustainable agriculture & forestry. ATTRACTISS has the goals to (1) empower ISS & all AKIS actors, through capacity building & provision of effective methods & supportive tools, to discover innovative ideas & enable uptake in a co-creative way thereby fostering AKIS ecosystem building to support the transition to sustainable and circular agriculture & forestry systems (2) support Managing Authorities (MA) in all EU MS to organise & monitor efficient support for ISS; & (3) provide support for new actors in AKIS processes to better facilitate co-creation approaches involving farming, practitioners & research centres. ATTRACTISS achieves these goals by (1) setting up an EU wide network for ISSs that allows to connect, develop common understanding, vision & capacities about their roles & functions within the AKIS. This ultimately leads to the development of an ecosystem in favor of Multi-Actor Approaches (MAA) & innovative projects; (2) building upon and giving continuity to other previous initiatives to focus on ISSs & broaden the networks; (3) systematizing the current databases & tools for ISSs to provide a unique virtual location for tools & guidelines to support best practice; (4) providing a step change in the provision of support & training for key actors in MAA & ISS across MS which builds knowledge, understanding & confidence in the practical delivery & benefits of these approaches; & (5) enabling institutional dialogue among ISSs & MAs based on enhanced understanding of the potential to organize ISS in a way that will lead to targeted CAP interventions for the integration of ISS within the AKIS.

Keywords: akis,innovation support services,multi actor approach
3D Imaging of Conductance Networks at the Nanoscale (IMACON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway,New Zealand
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-08-31
Duration (months): 36.0
Total project cost (EUR): 350668.08
EU funding (EUR): 350668.08
Participants: 2
Project status: SIGNED

Beyond classical devices, functional material, such as ferroic materials, hold great promise for future nanoelectronic device concepts, enabling faster, smarter and more energy efficient computation. This new generation of materials develops in the direction of increased system complexity, and often involves complex 3D structures at the nanoscale with atomically sharp interfaces. The progress is catalyzed by the ability to resolve their properties at the relevant length scales, an increasingly difficult task. As an MSCA fellow, Dr. Kasper Hunnestad will integrate migration, an existing computational method in geophysics, to conductive atomic force miscopy (cAFM). cAFM is typically limited to surface conductance measurements, whereas migration is a powerful technique employed for converting surface acquisitions of seismic data to subsurface 3D images. With Dr. Hunnestad’s background in both material science and geophysics, he can effectively develop this multidisciplinary method and exploit it to reveal 3D transport properties of exotic topological states in functional oxides. To begin the research, a two-year research stay at the University of Canterbury will enable two primary objectives: i) Develop the computational method migration for cAFM purposes ii) Perform experiments on materials hosting exotic topological states with technological potential. In the return phase at the University of Oslo, the technique will be benchmarked against established electrical characterization techniques, leading to the final objective: iii) Correlate quantitative electrical measurements to the cAFM data The research will pave the way for future investigations of 3D systems, largely expanding other researchers capabilities to understand their materials. Furthermore, it will strengthen Dr. Hunnestad’s network and competence, bringing him in contact with experts in the relevant scientific disciplines: ferroic materials, computational methods and electrical characterization.

Keywords: geophysical signal processing combined with nanoscale transport measurements for 3d imaging capabilities
Regaining control of cancer at biological borders (BorderControl)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

During dissemination, cancer cells must face and overcome several physiological borders, including the immediate stroma for local invasion and the endothelium for long-distance metastasis. At these critical junctures, cell plasticity between epithelial (E) and mesenchymal (M) states could determine metastasis potential. Based on our preliminary data, ideally-positioned cues emanating from the normal stroma contain the tumour in situ. Once this first border is breached, rare cancer cell-endothelial interactions trigger further dissemination through the vascular border. Moreover, cancer cell plasticity is vital throughout this process, enabling optimal response to distinct border microenvironments. In BorderControl, we will build on our cutting-edge cell biology expertise and close collaboration with clinicians to define the molecular signals underlying these border “crossings” and gain unprecedented information on how cancer cells overwhelm these natural defences. Starting with patient tissues, we will spatially profile the tumour-stroma border to identify receptor-ligand pairs that regulate invasion. We will use microfluidics to image, catch and profile cancer cell crossings at endothelial hotspots and determine key molecular regulators of the process in endothelial and cancer cells. Building on our novel discovery of endosomally regulated E-M cell states, we will test how E-M transitions impact border-breaching potential. These novel concepts will be investigated with interdisciplinary methods (scRNAseq, synthetic biology, colour barcoded HTS) and our new technologies (dynamically tuneable multicell-type migration and invasion imaging platforms) to determine the specific interactions/mechanisms regulating border crossings. Finally, we will take the molecular level discoveries from the cancer-limiting borders back to the patients, assessing clinical relevance using designer TMAs, and expect to uncover novel biomarkers and therapeutically actionable targets.

Keywords: cancer,metastasis,receptor ligand interaction,advanced light microscopy,patient samples,e cadherin,cell cell adhesion
NEXT GENERATION SUSTAINABLE BUSINESS MODELS AND MONITORING FOR RURAL RESILIENCE AND INNOVATION (NEXRUR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Spain,Sweden,Belgium,Greece,France,Hungary,China,Austria
Call: New sustainable business and production models for farmers and rural communities (HORIZON-CL6-2024-COMMUNITIES-02, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 6016160.0
EU funding (EUR): 5999774.5
Participants: 32
Project status: SIGNED

Rural areas and agriculture are facing major economic, social and environmental challenges regarding climate change, biodiversity loss and water supply. As a consequence, there is a need for new or improved innovative business and production models in rural areas that tackle these challenges and have impact on sustainability, both upstream and downstream of their business. NEXRUR´s main objective is to investigate the innovation dynamics and strategies for change in rural areas, through international cooperation between the EU and China, enabling farmers and their communities to develop, select and upscale new or improved sustainable business models and monitor their economic, social and environmental impact on rural resilience. The project is addressed to the Area A of the topic. NEXRUR will generate new knowledge on community-led agricultural business models, bringing together conceptual with practical research, thereby contributing to the generation of a knowledge base and facilitating co-design and co-innovation in a network of 22 diverse community cases (15 in the EU and 7 in China) and 7 selected start-up cases (5 in the EU and 2 in China) based on sustainability performance criteria. Besides, NEXRUR will verify the social and environmental performance of community-led agricultural businesses in different contexts, agri-food value chains, pedoclimatic zones and socioeconomic and environmental conditions in the EU and China. NEXRUR´s results comprise a summary of tested and improved pathways, strategies, tools and policy recommendations for the successful community-led businesses model development. Both the new knowledge generated and a monitoring framework for agricultural businesses and associated tool focused on environmental and social KPIs derived from the project, will be widely disseminated in the EU and China inspiring the uptake of new or improved production activities able to increase the prosperity of farmers.

Keywords: agricultural business models,community led,social and environmental performance impact kpis,monitoring,rural resilience,co design,joint learning,outscaling,upscaling,replication
Stand-alone Photoelectrochemical Tandem Devices for Solar-driven Overall Water Splitting (NECTAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

The project proposes to convert solar energy into hydrogen fuel by utilizing a thermoelectric integrated tandem photoelectrochemical (PEC) system with the main goal of generating a robust, scalable, and competitive solution of solar energy technologies. The project will focus on materials development, rigorous characterization, cell development, and prototyping. We will utilize solution-based techniques to address the urgent need for efficient absorbers for PEC systems via transferable methods for large scale production. We will target cost-effective and abundant materials for all required components without sacrificing their performance. Our proposed system will be the first work on solar driven-overall water splitting utilizing solution processing routes with benign molecular ink for photoabsorber synthesis coupled with earth-abundant and low-cost material cocatalysts. Furthermore, rigorous in-situ characterization will provide an overview of the overall processes involved in PEC reactions which will further guide system design. Finally, a prototype of an efficient and durable PEC cell will be realized.

Keywords: water splitting,tandem,pec,kesterites,photovoltaics,photochemistry,photocatalysis
Novel business model enabled by a patented fermentation technology to produce 100% biodegradable textile fibres from CO2-emissions (CO2TEXTILE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3226250.0
EU funding (EUR): 2258375.0
Participants: 1
Project status: SIGNED

Our innovation is the creation of a disruptive business model in the textile industry by establishing a new interconnection between two industrial value chains that are typically not connected: CO2-emitting industry such as energy intense sectors, e.g. chemical industry, and the textile industry. The innovation is enabled by our patented fermentation technology which turns harmful industrial CO2-gases into valuable, 100% biodegradable biopolymers. We capture CO2 emissions before their release into the atmosphere and use them as feedstock to produce added-value PHA biopolymers through a highly efficient, high-yield fermentation process. In this process, 2.5 tonnes of CO2 are turned into 1 tonne of PHA biopolymer, from which textile fibres are produced and sold at current market prices (€1/kg). The material can be used for several years and fully decomposes within 1 year in industrial or home compost conditions or in the marine environment, thus preventing plastic pollution.

Keywords: bioprocessing technologies,environmental and green technologies,microplastics,bioeconomy
The role of cell type-specific timing in the robustness of development (TIMERR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1648555.0
EU funding (EUR): 1648555.0
Participants: 1
Project status: SIGNED

Reproducibility in development is maintained via precisely-timed execution of gene regulatory programs required to build all cell types of the embryo. However, many perturbations challenge this robustness and accelerate developmental tempo, leading to increased phenotypic variability. Mechanisms underlying this century-old observation have been obscured by variation inherent to embryogenesis, but advances in statistical single-cell profiling have revealed an unappreciated source of variability: non-uniform progression of development across cell types. Here, I propose to use a combination of ultra-scalable single-cell genomics, cross-species alignment of developmental trajectories, and engineering of developmental rate to understand how cell type-specific timing differences influence reproducibility of development. First, comparing vertebrate species with natural tempo differences, fast-developing zebrafish (Danio rerio) and slow-developing medaka (Oryzias latipes), we aim to generate time-resolved single-cell transcriptomic profiles and map variation in cell type-specific timing. We will relate timing variation to a quantitative robustness measure derived from cell composition profiles for hundreds of embryos, asking how the tempo of development influences its ability to reproducibly build a well-proportioned animal. Second, we aim to identify cell type-specific drivers of timing and coordination. Specifically, we will modulate tempo embryo-wide and test for proportional timing changes across cells by tracking responses to perturbation at the cell type level. We will then use genetic tools to promote lineage-specific acceleration of development, assessing the embryo’s capacity to compensate for an induced asynchrony. In challenging coordinated developmental progression in evolutionary, perturbation, and synthetic contexts, we will resolve how timing impacts reproducibility in development.

Keywords: developmental robustness,developmental timing
PANDEMIC PREPAREDNESS THROUGH INTRANASAL ADMINISTRATION OF BROADLY EFFECTIVE MONOCLONAL ANTIBODIES AGAINST ALL INFLUENZA STRAINS (PanFlu)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Respiratory infectious diseases pose a significant threat to global health, spreading rapidly and hindering containment. The COVID-19 pandemic, with over 450 million cases in two years, highlighted the need for effective preventive measures beyond vaccines and antivirals, which have notable limitations. Leyden Labs is pioneering a groundbreaking platform to counter evolving viral threats with nasal sprays developed using the world's most broadly-neutralizing anti-influenza antibody (name disclosed in the short proposal). Our technology features high-affinity binding antibodies targeting the virus to prevent immune escape, with intranasal delivery ensuring targeted protection at the infection site for enhanced efficacy and convenience. Our primary market is EU healthcare providers, working closely with EU health authorities for effective pandemic response. Success in the EU will pave the way for global expansion, including the US market. Our nasal sprays will be available by prescription and through government partnerships, with revenue from insurance coverage and government contracts. This innovative platform aims to significantly improve pandemic preparedness and global health security. EU funding is crucial for financial support and strategic collaborations with EU healthcare providers, positioning us as leaders in healthcare innovation. The 2024 EIC Accelerator challenge will support the development of broad-spectrum monoclonal antibody-based therapeutics, ensuring efficacy against resistant variants.

Keywords: pandemic influenza monoclonal antibodies antibodies prophylaxis therapeutics