Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Casimir Self-Assembly out of Equilibrium (CASAlibra)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2469830.0
EU funding (EUR): 2469830.0
Participants: 1
Project status: SIGNED

Self-assembly is an important area of research that has numerous practical applications, including in the fields of materials science, nanotechnology, and biotechnology. Despite its widespread use, conventional self-assembly is limited, especially in terms of complexity, scalability, and dynamical control. In this context, a promising solution to these challenges is the use of Casimir self-assembly, which leverages the fundamental physics of the Casimir effect. The Casimir effect refers to the force that arises between two closely spaced metallic plates in free space, which results from zero-point fluctuations of the quantum vacuum. This effect can be harnessed for self-assembly by engineering the surface properties of the plates and the surrounding environment. In my proposal, I will utilize the interplay between fundamental quantum electrodynamics, Casimir physics, strong light-matter interactions, and non-equilibrium thermodynamics to develop a new, highly controlled, versatile and unique form of self-assembly. Crucially, the employed methodology enables the observation of the Casimir effect in aqueous solutions at room temperature with unprecedented precision of 1 nm. This method can be combined with micro- and nanofluidics, frustrated and templated self-assembly approaches, and non-equilibrium thermodynamics. Additionally, the unique combination of self-assembled Fabry-Pérot microcavities and the creation of nano-channels with exceptional material and heat transport properties further enhances the methodology's versatility. By combining these fields, I aim to create a new type of self-assembly that overcomes the limitations of conventional methods, providing greater complexity, flexibility, and dynamical control. In doing so, I will open up new avenues for fundamental physics, materials science, nanotechnology, and biotechnology, and lay the foundation for a new era of self-assembly that is more dynamic, sophisticated, and visionary.

Keywords: casimir effect,nanophotonics,microcavity,self assembly,strong light matter coupling,polariton
The politics of love: Marriage migration and governance in Spain, Italy and the United Kingdom (POL-LOV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United Kingdom,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: CLOSED

At a time when migration is increasingly reduced to an object of state security, POL-LOV focuses on the legal, political, and, most importantly, affective relationship between state institutions, especially those in charge of migration, and migrants who are married to European citizens and who seek to regularize their legal status. Through the paired case of Spain and Italy (southern border countries in the EU) and the United Kingdom (a country that recently left the EU), POL- LOV addresses the following empirical research questions: How do state bureaucracies scrutinize, evaluate, and quantify “love” in their decision-making processes about marriage migration? How do marriage migrants, especially women, experience these bureaucratic encounters? By addressing these research questions, POL- LOV pursues two main objectives: 1) advancing social science theorizing about the role of emotions, especially “moral emotions” , in how state institutions operate; and 2) improving our understanding of how the everyday encounters of marriage migrants with state bureaucracies affect meanings and practices and performances of romantic love across borders. POL-LOV is highly original and ambitious in its research design as it develops an interactional perspective focused on the relationships between the state and marriage migrants . The methodology involves capturing state moral emotions through the classic anthropological tools of ethnography: in-depth interviews, participant observation and semi- structured interviews. In practice, this means interviewing policymakers, lawyers and officials in embassies, police headquarters and migration offices. Since there is a methodological focus on both sides of the encounters (state bureaucrats and migrants) I will also do participant observation and in- depth interviews with marriage migrants and its partners and see how they navigate state suspicion and scrutiny.

Keywords: ethnographic methods,marriage migration,sociology of emotions,migration studies,legal anthropology
Tools4Teams: Research Training to Design and Implement Tools Supporting Safe Teamwork in Healthcare (Tools4Teams)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Denmark,Germany,Ireland,Norway,Switzerland,Greece
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2569212.0
EU funding (EUR): 2569212.0
Participants: 21
Project status: SIGNED

There is a large body of evidence demonstrating that effective teamwork by healthcare teams is crucial to maintain safe and effective patient care in complex care contexts. Complexity of healthcare is rapidly increasing due to technological innovation, increasing healthcare specialisation and decentralisation of care provision. Teams urgently need innovative tools that support team interactions to augment their situation awareness of and responsiveness to complex healthcare situations. Both in centralized acute care settings and in decentralized chronic care settings there is an urgent need to deeper understand team performance in complex situations and to apply this knowledge in the design and implementation of innovative tools in training and real-time application. Tools4Teams aims to establish a European training network to prepare the next generation of teamwork experts to contribute to the next step in safe and effective care. Tools4Teams brings together expertise from social and technical sciences, human centred design, education, and clinical specialties alongside non-academic partners from technological business, healthcare, and education to reach both scientific and societal impact. Tools4Teams recognizes and builds upon the transformative opportunities created by the application of behavioural sciences methodologies in healthcare and extend it with human centred design of tools as to impact upon the most challenging problems in research and delivery of safe and effective care. Mixed-methods designs will be applied to advance the scientific knowledge on evidence-based training and tools: 1. to support team interaction processes; 2. to integrate patient involvement in teamwork; 3. to support multiple team performance; 4. to facilitate innovative training (i.e. virtual and augmented reality). This research has practical implications for healthcare as a whole and will benefit clinician teams and the patients for whom they care.

Keywords: complex health care systems,multiprofessional teamwork,patient safety,acute hospital care,chronic care,community care,human centered design,teamtraining,non technical skills,implementation
Development and validation of a quantitative point-of-care test for the measurement of severity biomarkers to improve risk stratification of fever syndromes and enhance child survival (EChiLiBRiST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Mozambique,Gabon,Canada,United Kingdom,Portugal,Italy
Call: Innovative approaches to enhance poverty-related diseases research in sub-Saharan Africa (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 6935380.75
EU funding (EUR): 6935380.75
Participants: 14
Project status: SIGNED

Fever is the leading reason to seek healthcare globally, with over 1 billion cases of febrile illness occurring in children annually. The vast majority of infections are uncomplicated and self-limited and can be treated conservatively. A few (<1%) are life-threatening but are often challenging to identify early in the course of illness. Our project challenges the current status quo and inefficiencies of triaging practices. We propose to develop and validate a rapid triaging tool to determine, objectively, quantitatively and with high precision those patients at risk of dying, so as to prioritize their care. The breakthrough solution lies in the ENDOTHELIUM, a newly recognized in vivo biosensor, which plays a critical role in our defense against pathogens. Endothelial cell activation and subsequent loss of integrity is a common pathway of injury in several life-threatening infections, including sepsis, malaria, or even COVID-19. Measuring specific mediators of this pathway (sTREM-1, Ang2, etc.) at first clinical presentation can reliably identify individuals at risk of dying, irrespective of the disease causing the fever, and more robustly than previously known predictors such as clinical algorithms or "classic" biomarkers. Importantly, these pathways are also "druggable", thus allowing the testing or re-purposing of specific interventions to improve outcome. We will design and produce a RTT (glucometer-like) that quantitatively measures the two markers with best predictive performance (sTREM-1 and Ang2). We will then incorporate it into 2 clinical trials (to be done in Mozambique, Gabon and Ethiopia) to 1) verify the improved performance of the proposed PoC RTT in risk-stratifying and predicting mortality among paediatric patients when compared to standard of care, and 2) test whether a specific intervention (nutritional supplementation of L-Citrulline), guided by biomarker results, improves (vs. placebo) long-term outcomes and survival after hospital discharge.

Keywords: biomarkers,risk stratification,fever,triage,severity,mortality,prognosis,post discharge mortality,endothelium,host response,child survival,point of care
European Glaucoma Research Training program - Advancing the Approach of Advanced glaucoma (EGRET-AAA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Germany,France,Norway,Belgium,United States
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-12-31
Duration (months): 59.0
Total project cost (EUR): 4244509.03
EU funding (EUR): 4116902.4
Participants: 27
Project status: SIGNED

EGRET-AAA is a joint doctorate program to provide training in glaucoma research, leading to joint doctoral degrees for 15 ESRs. It converts existing partnerships between universities into long-lasting ones. Together with many private and societal partners, our consortium forms a cradle for a European network of highly skilled, resilient, entrepreneurial and creative researchers, who will inspire each other to excel in glaucoma research, both during and long after the funding period. EGRET-AAA will produce innovative treatments to protect and restore vision in patients with progressive eye disease glaucoma. By using revolutionary human retinal organoids, we will accelerate the development of new treatments and bring gene therapy and stem cell-based approaches a major step closer to clinical implementation, while minimizing the need for animal research. Through our findings, we will be able to protect the regenerated eye-brain connections and develop diagnostic techniques to select patients suitable for treatment and to evaluate intervention effects. By doing so, we will ultimately save approximately 1 million Europeans from blindness, and another 5 million from significant vision loss, thereby increasing their quality of life, and dramatically reducing societal and health care costs. Through our interdisciplinary and inter-sectoral training, the 15 ESRs will gain essential skills and assets for success in a broad range of careers in academia and beyond. Based on our previous experience gained on multiple training networks, we believe that this timely program provides an in-depth graduate research training environment of unrivalled quality and pertinence, far greater and better than the sum of its parts. By anticipating continued demand for the skills and experience of our ESRs, we see EGRET-AAA as the precursor of a permanent and sustainable glaucoma-focused European doctoral program.

Keywords: glaucoma,retinal organoids,stem cells,neuroprotection,retinal perfusion,ischemia,risk factor,ophthalmic imaging,visual function,cortical function,perimetry,regenerative medicine
Quantum Universal Photonics Integrated Circuit platform (QU-PIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,France,Germany,Spain,Sweden
Call: Quantum Photonic Integrated Circuit technologies (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6685203.71
EU funding (EUR): 5947868.0
Participants: 12
Project status: SIGNED

Quantum technology holds the promise of enabling next generation computing, communications and sensing systems. However, the size, cost and scalability of current devices prevents them from reaching their full potential. Photonics is one of the key enabling technologies for quantum technology. In particular, photonics integrated circuits (PICs) with their wafer-level manufacturing based on microfabrication technologies can provide the reduction in size and cost and enable next generation scalable quantum technologies. To fully achieve this goal, an universal PIC technology that can serve most quantum applications is needed. In QU-PIC, we selected the Al2O3 integrated photonics platform as backbone technology for the development of quantum PICs thanks to its excellent low propagation loss performance and wide operating spectral region from the ultraviolet (200 nm) until the mid-infrared. A large range of PIC building blocks is developed in QU-PIC, focusing on areas where materials or integration technologies are not yet available. Several light sources, including multiwavelength tunable lasers with operation at 399 nm, 411 nm and 935 nm on the PIC, UVC external cavity lasers emitting at 280 nm, sources of squeezed photons, single photon detectors, programmable ASICs and the required packaging and assembly technologies will be investigated. An open PDK will group all the developed quantum building blocks to accelerate innovation from the initial idea to an actually manufactured system. Two application demonstrators will be implemented using the developed building blocks, namely a source of GKP states for quantum processing and an atomic clock based on Yb+ ions for quantum sensing. It is the ambition of QU-PIC to secure a full European supply chain to establish Europe’s Sovereignty and manufacturing capabilities in photonics integrated circuits for quantum.
Model-based estimation of railroad wheel-to-rail profile change and contact forces (DETECT4WE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-11-30
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 3
Project status: CLOSED

The EU wants to encourage train travel due to the current climate crisis and innovations to the railway system are necessary. Because trains run around the clock in 2–3-minute intervals, it is difficult to monitor the status or the conditions of a railway equipment efficiently without interrupting railway operation and it only reduces the likelihood of its failure. DETECT4WE will offer a novel solution to help keep infrastructure safe. In this project, the condition of the tracks and the in-service trains are continuously monitored by smart sensors and the collected measurement data and safety analysis of trains are processed in real time. Therefore, a highly detailed forecast is ensured. This approach promises cost savings for vehicle manufacturers because of relatively inexpensive instrumentation techniques and shared computer analysis systems. And because more timely and accurate accident prevention will be available, train travel will become safer, leading to zero fatalities. The DETECT4WE project will be carried out by the experienced researcher who worked during her PhD thesis on the pure computational analysis of railway vehicle multibody dynamics and wanted to practice her research into applied railway engineering using experimental methods and make connections within railway industry. She will collaborate with Prof. José L. Escalona at University of Seville, Prof. Zili Li at Delft University of Technology. Both supervisors have strong background in computational and experimental dynamics of railway vehicles and tracks. In the end, a final six-months non-academic placement will be carried out at the company ProRail Ltd. under the supervision of Prof. Rolf Dollevoet. The academic and non-academic stay will give her the unique opportunity of modelling, experimentally testing, and validating innovative methods in the field of railway engineering, importantly extending her professional training towards becoming a self-supporting scientist.

Keywords: railway vehicle dynamics,multibody system dynamics,state observation,condition monitoring,railway maintenance,safety of the train ride
Towards Rational Understanding of the Fe-quarterpyridine-mediated CO2 Reduction to Solar Fuels (TRUSol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

The reduction of atmospheric CO2 to useful chemicals and fuels has been established as one of the most promising, clean and renewable alternatives to fossil fuels. Although the field has grown enormously during last years, information regarding mechanism and transient intermediates formed during the catalysis is still limited. TRUSol aims to explore the mechanism and the factors that control catalytic performance through the rational design of ligands and spectroscopic studies. With this goal in mind, we develop a strategy to synthesize a novel family of Fe-based quarterpyrine-based CO2 reduction catalysts. The new complexes will be tested photocatalytically, combining the molecular catalysts with mesoporous carbon nitride (mpg-C3N4) as semiconductor. The comparison of the complexes with fine-tuned ligands in regard to redox properties and photocatalytic activities will help to elucidate key aspects that govern kinetics and thermodynamics under turnover conditions. Complexes will first be explored under steady state and operando conditions by using a spectroscopic tool-kit including EPR, Mössbauer, X-ray absorption and emission spectroscopy to shed light on the electronic structures. Then, taking advantage of the ability of synchrotron techniques to selectively irradiate the metal center, laser/X-ray pump/probe time-resolved X-ray absorption and emission spectroscopy will investigate the highly reactive and/or short-lived transient intermediates in ps-ns time scales. TRUSol will put the fellow in a perfect position to achieve his career goal, a tenure track position in academia, through transferable skills such as project management, and scientific and personal training actions of the project. This interdisciplinary project promises a valuable mechanistic understanding to set the foundation of the rational design of future powerful CO2 reduction catalysts.

Keywords: co2 reduction,solar fuels,redox catalysis,molecular photocatalysis,electrochemistry,mechanistic studies,homogeneous catalysis