Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Postbiotic Restoration Of the Metabolome Of Moms (PRO-MOM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Microbial dysbiosis can lead to behavioral changes including aggressive behavior. Mice treated with antibiotics exhibit increased aggression, as do offspring of mothers given antibiotics only during pregnancy or alternatively only when nursing. Promising results from our lab in flies and mice support our hypothesis that such behaviors are partially affected by gut bacteria and associated metabolic compounds. Pregnancy is associated with reduced immune function and women receive antibiotics during this period for a myriad of reasons. Preclinical trials and clinical research suggest strong effects of these treatments on offspring. A postbiotic to be taken daily, in a manner similar to prenatal vitamins, following antibiotic use during pregnancy and breastfeeding can restore microbiota form and function, towards alleviating changes in offspring behavior. Throughout our ERC-funded research, BEHAVIOME, our approach to exploring the innovation potential of our research is a stepwise process. A direct result of this process was the identification of the ERC Proof of Concept as a viable route to defining the early commercialisation steps, and obtaining internal support to develop and implement the project. Within PRO-MOM, we aim to complete two critical objectives: significant progress on technology development (POC demonstration, in vivo pilot data), and achieving business readiness (market research, business plan, end-user engagement). The outcome of the ERC POC will enable us to take the last step pre-commercialisation, developing market readiness. For commercialization, our plan is to set up a spin-off company that will develop several postbiotic leads, either through funding raised through venture capital, or co-development with other larger companies in the field. With PRO-MOM we will develop a post-antibiotic supplement that promotes maternal-neonatal microbiota restructuring and reduces behavioral disturbances in the critical first 1000 days of life.
Theatre and Gentrification in the European City (THEAGENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Austria,United Kingdom,Poland,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1843311.0
EU funding (EUR): 1843311.0
Participants: 4
Project status: SIGNED

Since the European Middle Ages, the fates of theatre and the city have been intertwined. Mystery plays thrived amidst the urban guilds of medieval Paris, city comedies heralded merchant capitalism in seventeenth-century London, and Ottoman shadow puppetry shaped coffeehouse culture in nineteenth-century Istanbul. The emergence of the modern European city in particular was linked to the development of both state-sponsored and independent theatre institutions; theatre and performance practices drew on the human proximity that city living made possible, and shaped the visions of cultural heterogeneity that emerged from urban cohabitation. Today, unprecedented dynamics of migration, globalization, and rapid gentrification are fundamentally changing theatre’s importance in the urban environment. Theatre and performance practices are all but absent from urban studies, however, and theatre scholarship often views the urban question through a limited analytic lens. Combining multi-sited ethnographic and archival research, this interdisciplinary research project will focus on the key cities of London, Paris, Berlin, Warsaw and Istanbul to analyze the complicated and often ambivalent relationship between theatre practices and urban transformation in twenty-first-century Europe. Following key thematic threads like migration and memory, Theatre and Gentrification’s original case studies will illustrate the diversity of property relations and housing tenure across the European continent, as well as the complex roles that theatre and performance practices play in producing urban subjectivities and structuring the cultural politics of gentrification. Groundbreaking in its use of theatre as its vantage point, this ambitious project will change the way we think about the contradictions of culture in the twenty-first century city, from its role in securing claims to global urban stature, to its position within imaginaries of authentic local resistance.

Keywords: theatre,urbanity,gentrification,memory,migration
Twisting light and spin by chiral perovskites (TWIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999100.0
EU funding (EUR): 1999100.0
Participants: 1
Project status: SIGNED

Chirality, a fundamental property in chemistry and physics, plays a pivotal role in determining drug efficacy, advancing biomolecular analysis, and guiding the development of chiral optoelectronic devices. This concept becomes even more intriguing when integrated with halide perovskites, which are renowned for their exceptional optoelectronic properties. This integration gives rise to emergent phenomena such as chiral optical activity and chiral induced spin selectivity. These phenomena provide novel methods for manipulating light and electron spin, enabling advancements in quantum computing and innovative optoelectronic devices, including highly sensitive detectors and energy-efficient light-emitting diodes. However, fully harnessing this potential entails overcoming significant challenges in deciphering the complex quantum interactions underlying these phenomena. This necessitates a profound understanding of the interplay between light, charge, spin, and lattice vibrations within chiral perovskites. Addressing this challenge, the project pioneers an innovative computational framework that seamlessly integrates electronic structure theory, statistical physics, and molecular simulations. This multidisciplinary approach ensures computational efficiency while maintaining flexibility to incorporate additional theories and models. It provides access to gaining profound insights into the intricate physico-chemical mechanisms, as well as diverse structures and compositions to establish a robust structure-property relationship. Through this framework, this project aims to design unique chiral perovskites, which are expected to enhance the sensitivity of photodetectors and increase the energy efficiency of spin LEDs. Moreover, the fundamental insights from studying these materials extend beyond optoelectronics, influencing related disciplines in chemistry, biology, and the natural sciences, by offering new perspectives on chirality in both man-made and natural systems.

Keywords: halide perovskites,chiral materials,chiral optical activity,chiral induced spin selectivity,lattice dynamics,density functional theory,molecular dynamics
First ever preventive treatment for celiac disease and gluten sensitivity (Endoprotease 40 (E40))

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-06-01
End date: 2025-12-31
Duration (months): 31.0
Total project cost (EUR): 4243109.69
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

E40 is a novel gluten degrading enzyme aimed at enhancing the degradation of ingested gluten, particularly in gluten intolerant Celiac Disease (CeD) and Non-Celiac Gluten Sensitivity (NCGS) sufferers. Different from any other competing enzymes under development, E40 efficiently exerts its gluten degrading activity in both the stomach and the intestine of CeD and NCGS sufferers, supporting the benefits of a Gluten Free Diet (GFD). The final goal is to prevent symptomatology due to the pro-inflammatory reaction triggered by gluten. E40 will allow sufferers to manage inadvertent gluten exposure and will improve sufferer's Quality of Life, in particular allowing them to normalise their work and social life, reducing anxiety and allowing them to enjoy many everyday activities, like eating in a restaurant, travelling and visiting their friends in their homes. E40 is produced by an engineered, patented acidic Streptomyces lividans TK24 strain, and directly purified in its mature, functional form. E40 activity has already been confirmed using the validated human simulated digestion INFOGEST assay of real food digestion: E40 gluten degradation leads to a gluten-free status (residual gluten<20ppm as per EC guidelines).

Keywords: glutenase,preventive treatment,gluten intolerance,celiac disease
A life-changing PREssure Sensor System for UROdynamics to solve global urinary storage and voiding problems (PRESSURO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 6787550.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: CLOSED

900 million patients globally suffer from urinary dysfunction. Setting the right diagnosis and deciding upon the right treatment (medication, assistive devices, rehabilitation and/or surgery) can sometimes be very challenging. Today's technology provides a limited 15 min snapshot based on the artificial filling of the bladder. There is a clear need for a technology that can provide high resolution, accurate and realistic bladder pressure data over time based on natural filling. PRESSURO is a revolutionary micro and nanotechnology pressure sensor system based on more than 10 years of research at SINTEF. The sensor will be inserted directly into the bladder and enable continuous measurement based on natural physiology for up to 30 days. This solution will provide a completely new understanding of bladder function and enable better diagnosis and treatment for millions of patients.

Keywords: urinary dysfunction,bladder pressure,bladder function,bladder function monitoring,bladder dysfunction diagnosis,bladder pressure monitoring
THINK DEEP: Novel arts-based resources to reIMAGINE Artisanal Mining? (THINK DEEP-IMAGINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

THINK DEEP: IMAGINE?’s unique value proposition lies in its innovative arts-based response to the pressing challenge of ‘thinking differently’ about Artisanal and Small-Scale Mining (ASM). In 2019 the World Bank envisioned a new future for ASM in which this challenging sector escapes its persistently negative stereotypes to realise its central place within global development in socially and environmentally just ways. Such a vision is neither without controversy nor easy to achieve as ASM is plagued by two challenges: i.Data gaps and invisibilities – how to research a sector that is usually secretive, increasingly criminalised and often subject to underhand corporate and government practices? ii.Too simple stories of mining, which perpetuate imaginations of miners as victims of poverty and as unskilled social deviants and environmental pariahs. Breakthrough research with artisanal miners in Cambodia conducted on the ERC project THINK DEEP evidenced the value of novel arts-based research methods for tackling the first challenge, generating a unique archive of materials combining world-leading art with cutting-edge research. THINK DEEP: IMAGINE?’s high risk-high gain proposition is that arts-based resources created from this archive can respond to the second challenge. Building on THINK DEEP's benefit-sharing discussions and in collaboration with Cambodian artists, curators, researchers, miners and ASM stakeholders, we will i) experiment with and ii) evaluate the impacts of ‘putting research on display’ (via an exhibition, image-led book and online resources). Developing proof-of-concept for arts-based resources, we aim to: i. Reshape imaginations of Cambodia’s largely invisible and often dismissed ASM sector to tackle what local NGOs predict as its currently 'bleak futures.' ii. Develop a toolkit to share best-practice in producing arts-based resources on ASM, thereby supporting the World Bank in realising its vision for ASM’s place within global development.
Unravelling high CO2-induced changes in stomatal development (HIGHCODE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: CLOSED

Stomata are epidermal valves responsible for gas exchange in plant aerial tissues. Their number varies according to different environmental conditions, such as CO2 concentration. High CO2 levels negatively regulate stomatal development, but how such a repression works is poorly understood. In Arabidopsis thaliana, stomatal precursor cells develop asynchronously throughout leaf epidermis, undergoing a first asymmetric entry division that generates a small meristemoid and a larger stomatal lineage ground cell (SLGC). Meristemoids can go through up to three asymmetric amplifying divisions before forming mature stomata, while SLGCs can either undergo asymmetric spacing division or differentiate into pavement cells. How each of the three meristemoid division types are affected by CO2 is still unknown. Moreover, stomata form with the underlying mesophyll layer in a coordinated way. Both tissues are involved in CO2 sensing and high CO2 levels can affect their development. What are the factors regulating stomatal development modulation, and whether or not an interlayer coordination is required upon high CO2 conditions, has remained unexplored. The proposed project aims to unravel CO2-induced developmental response in leaf, understanding 1) how stomatal asymmetric divisions are affected by CO2, 2) what are the layer-specific regulators, 3) the mechanisms of developmental response. Spatiotemporal lineage tracing, tissue-specific transcriptomics and creation of selected mutant lines will be employed to elucidate how CO2 modulates leaf developmental program. To reach the proposed goals, I will be supervised in advanced confocal microscopy, bioinformatic analysis, oral and written communication of the research and developing of transferable skills. My previous experience as developmental biologist and with transcriptomic analysis, together with teaching and tutoring skills acquired, will help accomplishing the project goals.

Keywords: asymmetric cell division developmental plasticity co2 developmental response environmental regulation
Maximising the CO-benefits of agricultural Digitalisation through conducive digital ECoSystems (CODECS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Italy,France,Greece,Serbia,Slovenia,Latvia,Germany,Slovakia,Ireland,North Macedonia,Estonia,Czechia,Poland,Spain,Netherlands,United Kingdom,Hungary,Belgium
Call: Assessing the impacts of digital technologies in agriculture – cost, benefits and potential for sustainability gains (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 7150413.75
EU funding (EUR): 7150413.0
Participants: 33
Project status: SIGNED

CODECS will co-develop, together with farmers and AKIS actors, user-friendly approaches, methods, and tools able to document the co-benefits and the costs of technologies applied to real contexts. In this way, it will improve the collective capacity to understand, assess and foresee the full range of benefits and costs of farm digitalisation, and to build digital ecosystems that maximise the net benefits of digitalisation. CODECS will develop a vision of “sustainable digitalization” which will contribute to a multi-level transition that links social, economic, and ecological aspects together, by adopting an innovative system based / actor centred approach, and an action research methodology based on coordination of 21 Living Labs through interdisciplinary and transdisciplinary teams. The research will study the role of 'digital ecosystems' in the rate of uptake of digital technologies and in the distribution of their costs and benefits; will develop and test three indicators (farmers' digital readiness, scaling readiness, digital ecosystem conduciveness) to monitor the level of digitalisation and foresee its potential costs and benefits. It will assess and compare the full range of social, economic, and environmental costs and benefits of farm digitalisation, identifying synergies and trade-offs between different sources of costs and benefits; it will test and demonstrate digital technologies in 21 Living Labs through in physical and virtual demonstration. The CODECS platform will host search, demonstration, and assessment tools. CODECS has a strong commitment to get an impact in the AKIS domain and in the policy field, which will be put into practice through a dedicated work package on policy analysis and policy tools (iii) a set of policy briefs and webinars and an engagement strategy at local, national, European level through Living Labs, a science-policy interface, an AKIS network and a demo-farm network.

Keywords: digitalisation,co benefits,capabilities,digital ecosystems,scaling readiness,digital readiness,socio technical process modelling,agricultural knowledge and innovation systems,demo farms
In-vessel implantable smart sensing device for personalised medicine (IV-Lab)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Ireland,Spain,Germany
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 4158610.0
EU funding (EUR): 4158610.0
Participants: 5
Project status: SIGNED

The IV-Lab project aims at designing and manufacturing a miniaturized sensing device implantable in the blood vessel for monitoring the health status of patients. The micro-sensor-system would implement a body-embedded system with multiple sensing capabilities, targeting hemodynamic and biochemical parameters, once implanted into blood vessels (vein and/or arterial blood vessels) of vulnerable patients with cardiovascular diseases. The final goal of the proposal aims at responding the main requests from the Pathfinder Heath work program, that is to endow people with unperceivable sensors, which will allow 1. the continuous long-term monitoring of the health status, and 2. the diagnosis and personalized medical intervention. Once in the vessel, the sensor will be completely unobtrusive and capable of continuous monitoring. The implanted system will be connected with (and powered by) external data collection and communication system coupled trough standardized wireless technology (i.e. NFC), or even simply by a smartphone in case of asynchronous on-demand monitoring. The device will have miniaturized and shape size allowing the placemen inside veins and arteries without impairing the blood flow, and will be provided with multiple different sensors, able to work in a continuous or asynchronous way, depending on the specific use cases. This device will find important applications in the field of cardiovascular disease, in particular in those patients in which the detection of hemodynamic behavior and specific biomarkers could reduce the re-hospitalization and mortality (i.e. heart failure). Moreover, in perspective, the system will make possible to monitor the development and outcome of different disease, allowing a prompt and tailored treatment.

Keywords: implantable device in vessel bioelectronics 3d printing two photon lithography continuous monitoring hemodynamic parameters biomarkers heart failure personalized medicine