Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Detecting Local Adaptation with Climate-Informed Spatial Genetic Models (LocalAdaptation)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1999839.0
EU funding (EUR): 1999839.0
Participants: 1
Project status: CLOSED

Local adaptation, whereby individuals of a population exhibit higher fitness in their local environment compared to that experienced by other populations, has the potential to shape the distribution of genetic diversity and influence speciation. However, detecting and quantifying the extent of local adaptation is challenging, since neutral demographic processes can leave signatures which are hard to distinguish from those of local selection. In this project, I propose to quantify the extent of local adaptation in Anatomically Modern Humans by using climate-informed spatial genetic models (CISGeM) to reconstruct past population sizes, local movements, and range expansions, and thus provide a null model against which the signature of geographically-localised selection can be detected. In CISGeM, demography is affected by local resource availability, which in turn is defined by paleoclimate and paleovegetation reconstructions. By using these additional lines of evidence, it is possible to generate accurate demographic reconstructions for any number of populations, as well as integrating information from both modern and ancient genomes. Such spatially-explicit reconstructions are key for defining the expected neutral patterns due to complex demography, and thus allow us to isolate the signals of selection from this noisy background with high fidelity. The availability of paleoclimate reconstructions also enables formally testing hypotheses about the drivers of selection, integrating the changes in the strength of selection through space and time. While this project will be focused on Anatomically Modern Humans, the framework that I will develop will be applicable to the investigation of local adaptation from genomic data in any species. Such tools are very timely, given the ever-increasing availability of large genetic datasets thanks to the decreasing cost of genotyping and sequencing in both model and non-model organisms.
Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea (INMARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Ireland,Italy,Italy,Germany,Italy,Germany,Switzerland,Norway,Greece,Lithuania,Switzerland,Belgium,United Kingdom,Canada,Denmark,Portugal,United Kingdom,United Kingdom
Call: Enhancing the industrial exploitation potential of marine-derived enzymes (H2020-BG-2014-2, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 7396689.65
EU funding (EUR): 5999557.13
Participants: 28
Project status: CLOSED

INMARE stands for “Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea”. It is a collaborative Innovation Action to streamline the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals, drugs and in environmental clean-up applications. The INMARE consortium will unify the multidisciplinary expertise and facilities of academic and industry partners. This will include integrating the following core activities: advanced technologies to access and sample unique marine biodiversity hot-spots; state-of-the art technologies for construction of metagenomic libraries; innovative enzyme screening assays and platforms; cutting-edge sequence annotation pipelines and bioinformatics resources; high-end activity screening technology; bioanalytical and bioprocess engineering facilities and expertise, nanoparticle-biocatalysts; high-quality protein crystallization and structural analysis facilities and experts in IP management for biotechnology. The companies involved in the project are market leaders in enzyme production and biocatalysis processes designed to efficiently deliver safer (pharmaceuticals) cheaper (agriculture) and biobased (biopolymers) products. They also have impressive track record in environmental clean-up technologies and are committed to promoting public understanding, awareness and dissemination of scientific research. The main emphasis will be focused on streamlining and shortening the pipelines for enzyme and ‘bioactive compound’ discovery towards industrial applications through the establishing of marine enzyme collections with a high proportion of enzymes-“allrounders”. The project will also prioritize the identification of novel lead products and the delivery of improved prototypes for new biocatalytic processes.

Keywords: metagenomic enzyme mining,marine extremophiles,genomics,biocatalysis,bioactive compounds
Smart City Control System (SCCS) For Green Lighting (SCCS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Greinon Engineering AB aims to develop and commercialize an innovative, universal, multi-application Smart City Control System (SCCS) to be integrated with existing urban infrastructure. Smart outdoor lighting has been chosen as the primary application for SCCS capable of reducing energy consumption and cutting operational costs of the city lighting infrastructure, as well as optimize mobility, safety and well-being. SCCS comprises a modular wireless controller with embedded software, Graphical User Interface and a tailored software package with a Machine Learning algorithm, which will enable up to 85% reduction in energy consumption and significant maintenance savings for owners and/or operators of outdoor lighting infrastructure, improve relevant investment payback to 3 years and promote smart and sustainable urban management overall. The smart cities market size is estimated to reach EUR 673 billion in 2020, providing Greinon with a tremendous growth opportunity within the smart lighting control systems niche. Moreover, the company will address a range of important defies, incl. energy waste and climate destruction, increasing lighting costs and light pollution. The objective of the feasibility study is to improve the business plan including analysis and conclusion of: distribution and supply channels, technology risk reduction, IP strategy and preparation of demonstrations in the innovation project. Greinon will execute the project in cooperation with strategic 3rd parties and other stakeholders capable to provide technical and general expertise.

Keywords: energy effciency,smart lighting
Australasian Colonization Research: Origins of Seafaring to Sahul (ACROSS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1134928.0
EU funding (EUR): 826652.06
Participants: 2
Project status: SIGNED

One of the most exciting research questions within archaeology is that of the peopling of Australasia by at least c.50,000 years ago. This represents some of the earliest evidence of modern human colonization outside Africa, yet, even at the greatest sea-level lowstand, this migration would have involved seafaring. It is the maritime nature of this dispersal which makes it so important to questions of technological, cognitive and social human development. These issues have traditionally been the preserve of archaeologists, but with a multidisciplinary approach that embraces cutting-edge marine geophysical, hydrodynamic and archaeogenetic analyses, we now have the opportunity to examine the When, Where, Who and How of the earliest seafaring in world history. The voyage from Sunda (South East Asia) to Sahul (Australasia) provides evidence for the earliest ‘open water’ crossing in the world. A combination of the sparse number of early archaeological finds and the significant changes in the palaeolandscape and submergence of the broad north western Australian continental shelf, mean that little is known about the routes taken and what these crossings may have entailed. This project will combine research of the submerged palaeolandscape of the continental shelf to refine our knowledge of the onshore/offshore environment, identify potential submerged prehistoric sites and enhance our understanding of the palaeoshoreline and tidal regime. This will be combined with archaeogenetic research targeting mtDNA and Y-chromosome data to resolve questions of demography and dating. For the first time this project takes a truly multidisciplinary approach to address the colonization of Sahul, providing an unique opportunity to tackle some of the most important questions about human origins, the relationship between humans and the changing environment, population dynamics and migration, seafaring technology, social organisation and cognition.

Keywords: marine,maritime,palaeolandscape,seafaring,migration
Bringing together Research and Industry for the Development of Glider Environmental Services (BRIDGES)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Germany,Spain,Cyprus,Norway,France,France,France,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,Portugal
Call: Delivering the sub-sea technologies for new services at sea (H2020-BG-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-08-31
Duration (months): 54.0
Total project cost (EUR): 7791810.0
EU funding (EUR): 7791810.0
Participants: 25
Project status: CLOSED

BRIDGES (Bringing together Research and Industry for the Development of Glider Environmental Services) will provide a necessary tool for further understanding, improved monitoring, and responsible exploitation of the marine environment while assuring its long-term preservation. This new tool, a robust, cost-effective, re-locatable, versatile and easily-deployed ocean glider, will support autonomous, long-term in-situ exploration of the deep ocean at large spatio-temporal scales. The sole European underwater glider: SeaExplorer will be modularized, new sensors will be developed, and the operational methodology will be modified, such that new horizons of service will be opened. It will be improved by: 1) adapting for deep basins (up to 5000 m), 2) implementing a novel payload architecture to increase autonomy and to accommodate the range of sensing capabilities needed, and 3) integrating the associated control support system for single and networked operations (mission behaviour, data management, planning, communications). The glider’s sensing capabilities will be enhanced. The main modules are planned for: 1) environmental monitoring for facilitating the effective implementation of an ecosystem-based management under the Marine Strategy Framework Directive, 2) the oil and gas industry, and 3) the deep sea mining industry. In order to achieve the technological objectives and meet service requirements, an open dialogue between stakeholders will be developed. The basic premises of the present call “Delivering sub-sea technologies for new services at sea-BG-06-2014,” are answered thoroughly: the ability to execute unmanned underwater operations, to operate in the deep ocean, and to assess the environmental impact of the maritime economy. In addition, this project will realize and promote the creation of collaborations among sensor and platform manufacturers, oil and gas and mining companies, public health and safety departments, and scientific and engineering experts.

Keywords: underwater glider,oil and gas industry,marine strategy framework directive,living resources,deep sea mining,ocean management,ocean monitoring
Beasts to Craft: BioCodicology as a new approach to the study of parchment manuscripts (B2C)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France,Denmark,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-12-01
End date: 2024-08-31
Duration (months): 69.0
Total project cost (EUR): 2499462.0
EU funding (EUR): 1338609.5
Participants: 5
Project status: SIGNED

The intention of Beasts to Craft (B2C) is to document the biological and craft records in parchment in order to reveal the entangled histories of animal improvement and parchment production in Europe from 500-1900 AD. B2C will lay the foundations for a new approach to the the study of parchment manuscripts —biocodicology— which draws evidence from the overlooked first stages in production, the raising of livestock and the preparation of the skins. 1. Parchment is an extraordinary but overlooked high resolution zooarchaeological record and a molecular archive. Livestock genetics is revealing breed diversity and markers of character traits such as fleece quality. B2C will exploit this new-found knowledge, using progressively older dated archival (sheep) parchments to study the history of improvement 1300 - 1900. Visual examination of the skins will search for direct evidence of disease and fleece quality. 2. Craft skills can be read from parchment and, when combined with chemical data and comparison with modern analogues, will produce the first European wide record of the craft from 500-1900. The size and scope of this the parchment archive means it is one of the largest and most highly resolved records of a specialist medieval craft. We will explore how these skills develop and when and where regional patterns appear and decline. These two remarkable records requires a large interdisciplinary team. However biocodicology draws from and informs upon a wide and diverse spectrum of existing scholarship in conservation, the arts and sciences. A third strand of the project will (i) furnish manuscript scholars with some of the information available to the scribe at time of production (ii) inform and shape attitudes to parchment conservation (iii) provide high resolution biological data on animal management, movement and health and (iv) explore methods to link datasets and promote data reuse.

Keywords: partchment,craft,improvement
futuRE moBility vALues ANd CulturE (REBALANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Slovakia,Belgium,France
Call: The European mobility culture of tomorrow: Reinventing the wheel? (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 887692.32
EU funding (EUR): 851263.75
Participants: 6
Project status: CLOSED

REBALANCE will conduct an open deliberative forward-looking exercise towards a transformative transport policy in favour of a paradigm shift in mobility. It will push for the more effective ponderation of emerging social values not yet fully considered in transport policymaking, and a better alignment with the SDGs and the mounting concerns about climate change. To do so, REBALANCE will launch a Europe-wide high-level discussion on all the fundamentals of transport policy embedded in the current mobility paradigm. By critically reviewing the present -also in the light of the recent COV19 pandemic which drastically affected our lifestyles- the project will mobilise around the New Mobility Cultures and Policies Hub a wide network of transport experts and stakeholders to discuss and converge on a shared vision over a more sustainable path and jointly devise a roadmap for a new transport paradigm. The novelty, but also the strength of REBALANCE lays in the unconventional array of multidisciplinary thinkers that will contribute to the debate. As a new paradigm requires opening the windows of imagination, the project will count on the contribution of a multifaceted group of renowned philosophers, sociologists, social psychologists, geographers, and jurists that have not necessarily been involved in the past and current transport research debates. Their role is to provoke and shake the foundations of the current way of thinking and fertilize the continuing cultural and political deliberative process. The ultimate ambition is to reflect the joint effort in a Manifesto for a New Mobility Culture, to make sure that shared values and beliefs of Europeans are embedded in the fundamentals of the new transport policy, and lay the foundations for a long-term cultural change in the way people understand mobility and take decisions on transport policies.

Keywords: mobility,transport policy,culture,values,lifestyle,speed,public interest,paradigm shift,sdgs,climate change,environment,cov19,forward looking,manifesto
Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models (REVERSEAUTISM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1498394.0
EU funding (EUR): 1498394.0
Participants: 1
Project status: CLOSED

Autism Spectrum Disorders (ASD) are a group of neurological conditions characterized by stereotypical or repetitive behaviours as well as impairments in social interaction and communication skills, often of genetic basis. ASD have been classified as neurodevelopmental disorders, implying irreversible defects in the maturation of neural circuits. We have shown that mutations in the Branched Chain Ketoacid Dehydrogenase Kinase (BCKDK) gene lead to a potentially preventable and reversible form of ASD (Novarino et al. Science 2012). The most direct consequence of BCKDK mutations is a hyper-metabolism of the branched chain amino acids (BCAAs), resulting in atypically low levels of serum and brain BCAAs. Recently, using whole exome sequencing we identified individuals with ASD carrying mutations in the gene SLC7A5, encoding for the transporter mediating BCAA flux across the blood brain barrier. This suggests that the BCAAs are critical for brain development and cognition and reinforces their link with ASD. The simple nature and availability of the BCAAs prompt raising the possibility that this group of amino acids may be employed to treat symptoms of other ASD. We aim at 1) elucidating the link between BCAAs, ASD, brain development and cognition; 2) exploring the possibility of employing the BCAAs to reverse symptoms caused by mutations of ASD-genes. The genetic analysis of ASD is untangling the etiological heterogeneity that may contribute to poor clinical trial outcome. However, recent studies, including our own (Novarino et al. Science 2014), show that genetic causes of neurological disorders converge along specific biological processes. Our third objective is to employ stem cell-derived human cerebral organoids to identify key molecular changes involved in the pathology of genetically distinct but functionally homogenous forms of ASD. These molecules may represent the target for future “broad spectrum” therapeutic strategies as well as potential biomarkers (aim 3).

Keywords: autism,neurodevelopmental diseases treatment,human embryonic stem cells
Helicopter Engine Air Intake OPtimization Tool (HElAIrcOPT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France
Call: Tools development for aerodynamic optimization on engine air intake (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-04
End date: 2018-07-03
Duration (months): 30.0
Total project cost (EUR): 529806.25
EU funding (EUR): 370860.0
Participants: 1
Project status: CLOSED

The objective of this topic is to set up an industrial and fully automatic optimal design tool, integrating software identified by the Topic Leader, in order to reach TRL6 at the end of the project. This tool has to be dedicated to rotorcraft engine air intake analysis and able to handle multi-objective, multi-parameters and multi-points optimization on a given CATIA CAD. An effective aerodynamic design of the engine air intakes is essential for ensuring a proper air supply to the first stage compressor and thus an efficient behavior of the whole engine installation. However, its optimization has to deal with a lot of requirements and constraints, not always linked to the engine performance itself, but often aiming at improving conflicting criterions. For instance, the engine air intakes design will have some impact as regards the three following different issues: • Volume specifications • Helicopter manufacturer specifications, along with the airframe performance level required • Engine manufacturer specifications, along with the engine performance level required In order to achieve the task, optimization will take into account 3 flight conditions. Among all optimization strategy available, due to CFD solver limited capabilities for adjoint computations, a Surrogate Based Optimization approach is proposed. It allows use of gradient free and global optimization method. Two optimizations are planned during the task: one without Inlet Barrier Filter and a last without. The final objective is to improve flow solution at Air Intake Plane from a distorsion and pressure losses aspect.

Keywords: aerodynamic,optimization,workflow,surrogate model