Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next generation decontamination: fast, effective, cheap and non-toxic (DELOX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hospital acquired infections affect 1 in every 14 patients, a number that goes as high as 1 in every 5 patients when considering intensive care units. Delox has the potential to change that. Decontamination is performed using several different methods and technologies nowadays. The most relevant one is sterilization, which is an expensive procedure, typically only affordable for very large hospital in well developed countries or outsourced to a specialized firm. In the laboratory and health context the use of Formaldehyde is also still frequent – because it is price competitive – but it is toxic and far from perfect. The state-of-the-art technology is VHP (Vaporized Hydrogen Peroxide) which is costly, expensive and energy intensive, as it requires heating Hydrogen Peroxide to 130oC. Our formulation – dryVHP – differs by needing to be heat up to only 60 oC to produce the same effect. It is also significantly cheaper. Delox will be initially brought to market for use in laboratory equipment (<2 m3) and then a more powerful and adjustable version will be launched to address the Hospital, clinics and food sectors. It is the business outcome of more than 6 years of research and it has the potential to disrupt the bio-decontamination and sterilization market, having gathered interest from several large stakeholders, and received awards and recognition. We have also already raised 371.8k€ from VC (300k), awards (10k), public startup vouchers (11k€) and the European Space Agency. Within this Phase 1 we will prepare the next steps of our development (technical and commercial) but also validate our technology by preparing pilots with relevant players to demonstrate in real environment and prepare robust case studies that will boost market acceptance. By bringing to the market a non-toxic bio-decontamination solution that is cheap, effective, rugged and non-toxic Delox will make bio-decontamination affordable and accessible everywhere.

Keywords: sterilization,decontamination,hospital,clinics,health,facilities,infections,bacteria,hydrogen peroxide,formaldehyde,non toxic,pharma,laboratories
Bright, coherent and focused light to resolve neural circuits (BRILLIANCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1430275.0
EU funding (EUR): 1430275.0
Participants: 1
Project status: SIGNED

The overarching goal of this project is to establish a novel technique for neuroimaging to probe large tissue volumes at the nanometre scale. Currently only electron microscopes are capable of generating data with sufficient resolving power for comprehensive exploration of the neural circuits that underlie brain function. With state of the art systems, imaging just one cubic mm of brain entails years of data collection, ultra-thin sectioning which is prone to errors and data loss, and prohibitive costs. Each circuit unit spans over large distances, thus access to millimetre sized volumes of view is essential for both fundamental and therapeutic discoveries in neurosciences. Today this is an unreachable goal. In contrast, X-ray microscopy facilitates rapid imaging of large samples but the resolving power is not sufficient to visualize neural connections. Thus, at present, resolving large neural circuits is hardly imaginable. The aim of this project is to overcome these limitations and to develop an integrative approach which will open new research perspectives. X-ray holographic nano-tomography is a 3D coherent imaging technique which is capable of generating exceptional contrast in soft tissue through phase contrast. The penetrating power of X-rays and the full-field, free space propagation setup enable rapid multiscale imaging of large samples which are opaque to visible light. By combining a highly brilliant X-ray nanoprobe, a carefully designed nanopositioning system, a cutting edge detection system and cryogenics for sample preservation, isotropic 3D spatial resolution better than 30 nm is conceivable. The objectives of this interdisciplinary project are to 1) develop a system for imaging neural circuits at synaptic level in large tissue volumes, including methods for sample preparation, image acquisition and image reconstruction 2) develop an automatic image analysis tool 3) create unprecedented maps of brain circuits with immediate impact in neurosciences.

Keywords: x ray phase contrast microscopy,nanoimaging,neuroimaging,image reconstruction,cryomicroscopy,connectomics,neural networks,machine learning,holography,image segmentation
Unlocking mechanisms of cyst Nematode Hatching for sustainable cyst nematode control (NemHatch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Cyst nematodes worldwide attack agricultural crops such as potato, sugar beet, rice and soybean and cause large losses in their yield. There is a great need for developing new control methods for cyst nematodes because 1) resistance in cultivars is overcome, 2) crop rotation is problematic and 3) most of the nematicides are banned. Plant roots secrete triterpenoid-like signaling molecules into the soil that are known to induce hatching of cyst nematodes, called hatching stimulants (HSs). In NemHatch, I will develop a new strategy to control cyst nematodes by manipulating the signaling relation – mediated by the HSs - between the host plant and the cyst nematodes. I will first create contrasting potato lines with different HS production by phenotyping potato genotypes and applying abiotic factors and stress hormones. Then I will use bioinformatics, biochemistry and forward as well as reverse genetics approaches to elucidate the HS biosynthetic pathway and its regulatory mechanism. This will allow me to create and identify genotypes that differ in HS production so I can study their importance for PCN resistance and possibly other physiological processes in the host plant. I will both obtain and transfer knowledge by secondment and visits to industrial partners. This project will expand my expertise in secondary metabolite biosynthesis with an ecological twist on the communication of plants with their abiotic and biotic environment, and I will learn advanced molecular breeding techniques. In addition, I will gain several skills such as project and IPR management. Vice versa, I will bring my expertise on triterpenoid biosynthesis and my molecular biology skills to the host. NemHatch will provide the fundamental knowledge enabling biotechnological and agronomical applications to control cyst nematodes and give me the chance to reach a state of professional maturity that will allow me to find an (independent) position in academia or industry.

Keywords: cyst nematode,triterpene biosynthesis,breeding,pest resistance,potato,genetic modify plant,crop production and protection,transcriptome analysis,plant metablism,biochemistry,plant physiology
Exposome project for health and occupational research (EPHOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Cyprus,Norway,Belgium,Greece,Sweden,Norway,Finland,France,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 12019351.64
EU funding (EUR): 11981851.64
Participants: 20
Project status: SIGNED

Exposures at the workplace contribute to many non-communicable diseases (NCDs) with a similar magnitude as urban air pollution or obesity. Given the associated societal and economic (2-6% GDP) pressure, ensuring a healthy work environment is a strategic goal for the European Commission. Demographic changes (aging workforce, female workers) and the rapidly changing nature of work with respect to secure employment and migration, are posing additional challenges. We define the working-life exposome as all occupational and related non-occupational factors (general and socio-economic environment, lifestyle, behaviour). Taking a working-life exposome approach will help address these challenges by providing better insights in how complex working-life exposures are related to NCDs, for vulnerable groups (female, migrant, insecure job workers) or life stages. The working-life exposome is in its infancy and new approaches and methods are needed. In EPHOR a consortium of exposure, health and data scientists and technology developers will develop a working-life exposome toolbox, with stakeholder involvement. The toolbox will make available to scientists, policy makers and occupational health practitioners: 1) innovative methods for collection, storage, and interpretation of more complete and individual level working life exposome data; 2) better knowledge on how the working life exposome relates to NCDs, including complex interactions, vulnerability, biological pathways and early signs of health damage, by uniquely combining large-scale pooling of existing cohorts with focused case studies; 3) models for assessing the economic and societal impact of working life exposures. EPHOR will lay the groundwork for evidence-based and cost-effective preventive actions to reduce the burden of NCDs as a result of the working-life exposome. Thereby, health, wellbeing and productivity of the EU population will be improved and the burden on the EU health care systems reduced. EPHOR is part of the European Human Exposome Network comprised of 9 projects selected from this same call.

Keywords: working life exposome,occupational exposure,cohort studies,sensors,job exposure matrix,omics,pathways,non communicable diseases,shift work,respiratory health,health and economic impact
The New era of EUropean CMB Cosmology with the South Pole Telescope (NEUCosmoS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1971587.0
EU funding (EUR): 1971587.0
Participants: 1
Project status: SIGNED

The goal of NEUCosmoS is to unravel some of the most severe inconsistencies that are currently threatening the so-far very successful standard model of cosmology (ΛCDM). The most critical one is the steadily growing 5σ difference in the measurement of the expansion rate of the universe today, the Hubble constant, from early-time probes (CMB) versus late-time ones (supernovae Ia). Additional discrepancies persist in the amplitude of matter perturbations, σ8, and in other fundamental parameters, such as the curvature of the universe. These anomalies, if confirmed, will have revolutionary implications for physics. In this context, NEUCosmoS will provide new, ground-breaking insight through the development of a robust analysis pipeline, allowing us to extract the most precise cosmological information from one of the forefront, post-Planck CMB experiments: the South Pole Telescope 3rd-Generation (SPT-3G). SPT-3G will measure the CMB small-scale polarization with unprecedented accuracy over the next 5 years, opening an entirely new window in CMB cosmology, with potentially original discoveries on its own. However, this statistical power will be useless without an analysis able to guarantee robustness against systematic effects, which the PI of this proposal is an expert on. For this reason, she was invited by the SPT collaboration to lead this effort, opening a unique opportunity of European access to the SPT-3G data. NEUCosmoS will provide a framework to transform the existing SPT-3G pipeline into one with quality comparable to satellite missions, building upon the PI’s Planck experience and tools, adapting them to the new challenge. The NEUCosmoS team will drive the interpretation of current and future hints of new physics in a reliable way, with statistical power comparable to the Planck satellite, and in combination with it, almost doubling the constraining capability. This will pave the way to a future contribution by Europe to the next-generation of CMB experiments.

Keywords: data analysis,hubble constant
In vivo histology using femtosecond laser multiphoton tomograph for the early diagnosis of skin cancer and corneal diseases while simultaneously reducing Europe’s health care costs (LASER-HISTO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 2477500.0
EU funding (EUR): 2477500.0
Participants: 1
Project status: CLOSED

1.3 million – this is the sad number of Europeans dying each year by cancer. JenLab, high-tech company from Germany, has therefore developed an innovative novel diagnostic medical device (TRL 7) based on femtosecond laser radiation for immediate, non-invasive early diagnosis of cancer, particularly skin cancer, within seconds and with ultra-high resolution depicting even subcellular level. This is also true for early detection of ophthalmic diseases which constitute a major burden for Europe’s society –knowing that one European in every 30 is expected to experience sight loss. In addition to intratissue cell imaging, JenLab’s technology is able to measure metabolic processes giving information about diseases even before they become visible – increasing therapy success by early detection and continuous monitoring. Moreover, the technology is applicable for imaging each tissue without labelling but using endogenous biomarkers. Outcome of the business innovation project is an miniaturised, certified and by clinical study validated ultracompact, flexible, fast multiphoton tomograph for dermatologists and ophthalmologists, representing an European market potential of EUR 11.4 bn. Particularly by its quick and reliable (using 4 different modes of diagnostic) way of diagnosis it meets user needs while simultaneously reducing Europe’s continuously growing health care costs. The business project is in line with JenLab’s philosophy of saving lifes and of facilitate healing as well as it is in line with JenLab’s strategy of developing and producing novel solutions for early diagnosis of life threatening and/or serious diseases.

Keywords: cancer,corneal diseases,biomarkers,validation,certification,multimodal imaging,high resolution imaging
Real and open Gromov-Witten theory (ROGW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2026-10-31
Duration (months): 74.0
Total project cost (EUR): 1351375.0
EU funding (EUR): 1351375.0
Participants: 1
Project status: SIGNED

This proposal focuses on establishing new relations between natural objects in symplectic geometry with other fields of mathematics including knot and representation theory and the theory of integrable systems. All of these relations are motivated by theoretical physics. The main objects of study are moduli spaces of pseudo-holomorphic maps giving rise to real and open Gromov-Witten invariants. The classical Gromov-Witten invariants were introduced by Gromov at the birth of symplectic topology giving rise to obstructions to symplectic embeddings. Their interpretation by Witten as the coefficients of a partition function of a field theory placed them in a new light : striking dualities understood in physics relate them to mathematical objects of completely different nature and on completely different manifolds. This has and continues to generate enormous amount of high-level research aimed at understanding these relations better. The proposed research concerns establishing such relations in the context of the recently introduced, by the PI and A. Zinger, real Gromov-Witten theory. In particular, it aims to determine the systems of differential equations governing the real Gromov-Witten theory, that parallel the KdV and Toda hierarchies in the classical case. We will further study the real Gromov-Witten theory of toric Calabi-Yau threefolds with the aim of establishing a connection with SO/Sp Chern-Simons theory and a real version of the remodeled mirror symmetry. Finally, we will seek to establish foundational results of open Gromov-Witten theory in a general context.

Keywords: real,open,gromov witten theory,symplectic geometry,integrable systems,knot theory,mirror symmetry
Fast rAdio technologieS for uninterrupTed TRAin to traCKside communications (FAST-TRACKS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The urbanization trends of the suburban metropolitan areas has increased exponentially the demand for high-capacity rail infrastructure, which require interoperable systems and services, with high standards of safety and reliability. At the same time, the railway technological infrastructure and the related services require a high level of innovation, especially in the field of telecommunication systems and rail control, which is still made using traditional systems, based on wired or relay electromechanical technology. In this context, the wireless telecommunication networks are playing an increasingly important role for the known functional, installation time and maintenance features: they are potentially able to develop robust systems with high redundancy that can simultaneously vehicular traffic data for automatic train control and the “massive” transfer of security and passengers control information. The business idea proposes the development and commercialization of a low cost system, which allows addressing the main problems faced at present in the integration of a traditional Wi-Fi system within the railway technological infrastructure. The proposed infrastructure, due to the high-speed capacity, dual embedded radio and configurable approach, permits to integrate vital and non-vital services on the same wireless backbone simply dedicating different radio to different services operating with a full redundant architecture. Thus, the system proposed will contribute to: • establish a high speed, reliable and continuous communication between a train in motion and the trackside, allowing capacity enhancement; • support Communication Based Train Control (CBTC) services; • collect data of CCTV (Close Circuit TV); • provide support for VoIP and Personal Information Systems (PIS) services; • enable preventive maintenance; • ensure passengers’ safety and security during their journey; • improve travel comfort; • provide real time multimedia information and access.

Keywords: railway,interoperable systems,rail control,signaling,wireless telecommunication networks,communication based train control,cloud seamless handover,wi fi geo localization
Additive Manufacturing of 3D Microfluidic MEMS for Lab-on-a-Chip applications (M3DLoC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Ireland,Austria,Germany,Germany,Spain,Spain,Ireland,Ireland,Greece,Belgium,Belgium,Belgium,Greece,France,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Pilot Lines for 3D printed and/or injection moulded polymeric or ceramic microfluidic MEMS (H2020-NMBP-PILOTS-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 9610849.16
EU funding (EUR): 7924157.76
Participants: 19
Project status: CLOSED

MEDLOC aims at the employment of multi-material 3D printing technologies for the large-scale fabrication of microfluidic MEMS for lab-on-a-chip and sensing applications. The concept is based on the combination of multimaterial direct-ink-writing method and an extrusion-based 3D printing pilot line, in order to fabricate microstructured detection devices with the ability to perform all steps of chemical analysis in an automated fashion. The functionality of these devices will be evaluated based on their ability to streamline all steps needed to obtain mobility and binding-based identity information in one continuous biochemical detection system. Optimum in-line control systems will be incorporated in various stages of the fabrication process, to achieve precise control and repeatability. Microfluidic MEMS are increasingly recognized as a unique technology field for the development of biomedical devices (BioMEMS), due to their functional performance on the microscale, at the dimensions of which most physiological processes are operative. Applications near micro- and nanoscale are promising in the field of intelligent biosensors, where it enables the monolithic integration of sensing devices with intelligent functions like molecular detection, signal analysis, electrical stimulation, data transmission, etc., in a single microchip.

Keywords: lab on a chip,sensors,3d printing pilot line