Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Bronze Age Cultures and technical evolution: a Phylogenetic Approach (BRONZE AGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 200049.6
EU funding (EUR): 200049.6
Participants: 1
Project status: CLOSED

European Bronze Age cultures (2200-800 BC) and archaeological material are generally studied in terms of finished artefacts. In contrast, the proposed research is centred on observing the physical modalities by which the raw material is transformed into a finished object: the chaîne opératoire. Technical behaviours represent a link with the body and mind, and are a consequence of the socio-cultural environment in which the individual developed. They are the result of a transfer of technical tradition from one generation to another, but are impossible to model with current tools because of the complex link between their evolution and the processes of invention. Using contemporary cultures, one insular (Deverel-Rimbury, UK) and the other continental (Duffaits Culture, France), the aim of this project is to understand and model the origin and evolution of the techno-diversity seen in Middle Bronze Age. Are these two cultures founded on learning and applying a transmitted technical tradition that evolved from a single source and then diversified (phylogenesis) or did it derive from multiple sources that then recombined in various way (ethnogenesis) ? Do we see a link between the nature of evolution and the geographical position of territory (insular vs continental) ? Does a « common ancestor » exist between insular and continental traditions ? Phylogenetic trees and networks are based on the principle of descent with modification and represent the best way to illustrate the ancestor-descendant relationships; they allow us to perceive the familial ties between technical traditons over time, to identify their common ancestor, and the endogenous or exogenous nature of the evolutionary processes. On the basis of the chaîne opératoire concept and a phylogeographic approach, together with a 3D geographical distribution model of the lineage, this multidisciplinary project aims to establish a new paradigm for Bronze Age and a new methodology for the anthropology of technology

Keywords: social sciences,prehistory,natural sciences,phylogeny
The Econometric Analysis of Mixed Frequency Data and its use in Policy Making (MIDAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-09-19
End date: 2013-09-18
Duration (months): 24.0
Total project cost (EUR): 198860.0
EU funding (EUR): 198860.0
Participants: 1
Project status: CLOSED

The project deals with methods that are applicable across different scientific disciplines and is therefore inherently multidisciplinary. Our focus, however, will be on economic applications, as this is our field of expertise. Economic time series are sampled at different frequencies. For example, financial markets data are available on a (intra-)daily basis, while many macroeconomic series are observed monthly or quarterly. The typical approach adopted in empirical research is to align the data at the lowest sampling frequency and run regressions with same-frequency data. This leads to loss of information. In addition, the availability of high frequency financial data represents an opportunity to update expectations about low frequency macroeconomic time series – something that is of key importance to policy decision makers. Our research pertains to methods that allow us to handle mixed frequency data in empirical research as well as provide tools for policy makers to use the steady flow of high frequency data to help guide their decision making process. The research is based on a framework, using so called MIDAS, meaning Mi(xed) Da(ta) S(ampling) regressions that involve data sampled at different frequencies. This research opens up many new areas, some of which have already been studied, while many others remain unexplored. The purpose of this research project is to study the many unexplored areas ranging from systemic risk monitoring to macroeconomic forecasting for the Euro area for the purpose of policy decision.

Keywords: cyclical economics,macroeconomics,econometrics
NOVEL LUMINESCENT UPCONVERSION NANOPARTICLES FOR DIAGNOSTIC AND THERAPEUTIC NANOMEDICINE (LUNAMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-08-01
End date: 2014-07-31
Duration (months): 36.0
Total project cost (EUR): 210359.2
EU funding (EUR): 210359.2
Participants: 1
Project status: CLOSED

This proposal describes novel up converting nanoparticles that promise minimal perturbation of living systems. The work is at the leading edge of science in cell targeting, imaging and diagnostic medicine. The outgoing part will be carried out in the laboratory of Professor John A. Capobianco an internationally recognized scientist. His laboratory offers a unique, multidisciplinary environment for developing and applying novel nanoparticles in biomedicine. It includes also gain state-of-the-art expertise in nanotechnology and access to a diverse learning environment encompassing, spectroscopy, inorganic chemistry, synthesis and characterization of nanoparticles and will have access to world-class infrastructure. The incoming part of the proposal will be carried out in Prof. Daniel Jaque group, which have a great experience in optical spectroscopy as demonstrates their prolific scientific achievements.

Keywords: microscopy,experimental physics,inorganic chemistry,solid state physics,anticancer therapy,cytology
A characterization of the effectors of a plant pathogen. (AY-WB EFFECTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-05-23
End date: 2013-05-22
Duration (months): 24.0
Total project cost (EUR): 201049.6
EU funding (EUR): 201049.6
Participants: 1
Project status: CLOSED

Phytoplasmas are intracellular bacterial pathogens of the class Mollicutes that can replicate in both plants and insects. The genome of Aster yellows phytoplasma strain witches’ broom (AY-WB) is predicted to encode 56 secreted virulence (effector) proteins, and we have determined that the expression of most of these genes is host-specific. However, the mechanism(s) by which phytoplasma gene expression is regulated is entirely unknown. Furthermore, only one of fifty-six putative effectors has been characterized. In this work, we seek to identify the regulatory elements that specify a host-specific transcriptional response by mapping the promoters of genes in insect- and plant-colonizing AY-WB. A comparison of plant-specific promoters versus those expressed primarily in insects will afford an opportunity to identify determinants important to the regulation of phytoplasma genes in these diverse hosts. Furthermore, we identify six candidate effector proteins which we hypothesize are secreted by AY-WB upon infection of a plant. We will determine if these proteins are genuine phytoplasma effectors by assessing their ability to interact with a plant and modulate plant phenotype. We will also employ immunohistology to determine whether these proteins migrate from the phloem to target developing tissues. As a means of identifying interacting proteins, we will perform a yeast two-hybrid screen against an Arabidopsis library, an initiative which has proven successful in the study of another AY-WB effector protein, SAP11. The proposed research project will offer valuable insight into the mechanisms by which phytoplasmas infect plants and modulate host growth and development.

Keywords: natural sciences,microbiology,phytoplasma,phytopathology,effector,insect,agricultural crops,promoter,plant
Brahms and the Fabric of Modernist Culture (BFM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-09-21
End date: 2014-09-20
Duration (months): 36.0
Total project cost (EUR): 226024.0
EU funding (EUR): 226024.0
Participants: 1
Project status: CLOSED

This large-scale project, to be carried out in the University of California, Irvine (outgoing phase) and University College Dublin (return phase) proposes to allow the expert researcher reach a level of professional maturity in the areas of research and teaching in the field of musicology, with a speciality in German music criticism and aesthetics of the late-nineteenth and twentieth centuries; the expert researcher aims to research and write a monograph in her field, to establish international collaborative relationships, to establish an international centre of excellence for music aesthetics–the first of its kind globally, and to secure a prominent lecturing post on her return to Europe. The research proposal, “Brahms and the Fabric of Modernist Culture” explores Modernism in relation to Brahms, and Brahms’s critics in relation to Modernism. It is an interdisciplinary project that focuses on the intersection between musicology, aesthetics, German studies, and philosophy. These Modernist critics, some of whom were born in the cultural atmosphere of the nineteenth century, and some of whose academic careers and writings were shaped by their twentieth-century critical, philosophical and academic milieu, include Hanslick, Nietzsche, Bloch, Schoenberg, and Adorno. This research will establish a model for uncovering how we shape perceptions of composers. It will explore the shaping of the subject that takes place while the composer is alive and for a period of approximately fifty years after their death. It will examine how the aesthetic persona is created, how linear chains of causal relationships are constructed in music criticism and music history, and assess the criteria by which a certain view of a composer obtains a dominant position. In its inter-disciplinary approach, this research, therefore, should provide a valuable model that can be applied to other composers.

Keywords: humanities,brahms,hanslick,nietzsche,bloch,adorno,musicology,aesthetics,criticism,philosophy,modernism,music,german studies,interdisciplinarity,nineteenth century,twentieth century
Regulation of obesity and fatty acid-induced inflammation by AMP-activated protein kinase in obese/type 2 diabetic and inactive human skeletal muscle. (AMPKANTIINFLAMMATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-07-08
End date: 2013-01-07
Duration (months): 18.0
Total project cost (EUR): 165442.8
EU funding (EUR): 165442.8
Participants: 1
Project status: CLOSED

It is increasingly recognised that obesity is characterised by chronic activation of inflammatory pathways in skeletal muscle and that this is a causative factor of obesity associated insulin resistance; also contributing to the pathogenesis of complications of diabetes. My work has shown that activation of AMP-activated protein kinase (AMPK) can regulate inflammatory signalling by antagonising fatty acid-induced NFκB and MAPK signalling (Green CJ et al., in preparation). The latter work was carried out in rat (L6) muscle cells, this project will confirm whether AMPK can regulate fatty acid/obesity-induced inflammatory signalling in human skeletal muscle cells from obese patients and assess to what extent pharmacological activation of AMPK can be utilised in humans to treat fatty acid-induced inflammation. The overall objectives of this project are to demonstrate that; 1) Isolated, cultured, skeletal muscle myocytes from obese patients retain their inflammatory phenotype as seen in vivo, 2) AMPK activating drugs can antagonise obesity associated inflammation in isolated skeletal muscle myocytes from obese, type 2 diabetic subjects, 3) to assess whether physical inactivity renders isolated skeletal muscle more susceptible to fatty acid-induced inflammation compared to healthy controls, and 4) to provide evidence that activation of AMPK, using insulin sensitising agents, can be used as an effective strategy to ameliorate obesity associated inflammation in humans at the whole body level.

Keywords: health sciences,nutrition related disorders,medical sciences,medicine,physiology,obesity,ampk,skeletal muscle,fatty-acid,insulin resistance
Accelerated myocardial perfusion, metabolic and contractile cardiovascular magnetic resonance imaging (ACCELCMR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 181101.6
EU funding (EUR): 181101.6
Participants: 1
Project status: CLOSED

Cardiovascular disease (CVD) remains the leading cause of death worldwide and the costs due to CVD are increasing. Early detection and correct treatment of CVD is therefore important and research on cardiovascular magnetic resonance (CMR) for imaging of myocardial viability, perfusion and contractility has been intensified. While these methods are already well developed and in use in clinical research and practice, data on metabolic changes associated with CVD are difficult to obtain in-vivo due to the low inherent sensitivity of CMR. With the advent of hyperpolarization methods, an opportunity for probing metabolism in the in-vivo heart with high resolution has emerged. The hyperpolarization is short-lived, however, and requires imaging with high scan efficiency during a short time window. The objective of this research proposal is to develop in-vivo metabolic imaging by exploiting and furthering latest technology developed for CMR scan acceleration and carbon hyperpolarization at the University and ETH Zurich. Joint assessment of the interrelation of perfusion, metabolism and contractile function of the heart will be used to study occlusion and reperfusion in an animal model, triggered by the ongoing debate about the cause of reperfusion injury during treatment of CVD. The applicant already has expertise in accelerated imaging for human applications based on research projects he carried out in Sweden and Japan. He is now seeking to add experience in animal imaging and metabolic spectroscopic imaging methods to his repertoire. By joining one of the world-leading institutions in CMR research he will efficiently contribute and profit from a cutting-edge research endeavor aimed at extending the diagnostic capabilities of CMR. Upon completion of the project the fellow is expected to have complemented his expertise to be able to become an independent researcher in academia or in the prominent European healthcare industry focusing on diagnostic imaging.

Keywords: magnetic resonance imaging,cardiology,perfusion,metabolism,function
Genetic analysis of a novel family of repulsive guidance cues acting through Unc5 receptors (FLRT IN NEUROBIOLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-06-01
End date: 2014-05-31
Duration (months): 24.0
Total project cost (EUR): 162742.4
EU funding (EUR): 162742.4
Participants: 1
Project status: CLOSED

One of the most challenging problems in neurobiology is to understand the mechanisms that mediate the formation of a functional neuronal network. Despite the identification of several molecules that regulate axon guidance and cell migration, it is unclear how these factors can specify a large number of connections in the nervous system. The present project aims to study the role and mechanism of action of the Fibronectin Leucine-Rich Transmembrane (FLRT) family protein in axon guidance and cell migration during mouse central nervous system (CNS) development. The proposed fellow intends to tackle this problem using a multidisciplinary approach including conditional mouse mutant mice lacking either specific FLRT or Unc5 proteins, cell based functional assays using neurons derived from mutant mice, and molecular and biochemical assays to identify signalling pathways activated by FLRTs. Recent unpublished results from the proposed host institution, the Department of Molecular Neurobiology (Dr. Klein) at Max Planck Institute of Neurobiology, indicate that shed ectodomains of FLRTs can function as long-range guidance cues for cortical neurons in vitro and in vivo. FLRTs exert their functions by binding to Unc5 receptors. Moreover, FLRTs may also act as cell autonomous signaling receptors. Thus, FLRT proteins have the potential to engage in bi-directional signaling (‘forward’ via Unc5 receptors and ‘reverse’ via their own intracellular domain), an original and innovative concept which Dr. Klein previously pioneered in the ephrin/Eph field. Should the hypothesis of the proposed research be correct, the findings will undoubtedly represent an advance in the state of art in the neurobiology area, and also may shed light on certain neural developmental disorders. The proposed fellow will highly benefit from the challenging research environment and supervision of a renowned scientist, which will offer him promising perspectives for his further research career in Europe.

Keywords: repulsive axon guidance,cell migration,unc5,leucine-rich repeat proteins
Dynamics and Structure in a Network-Forming Liquid (NFLIQUID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-03-26
End date: 2014-03-25
Duration (months): 24.0
Total project cost (EUR): 177380.8
EU funding (EUR): 177380.8
Participants: 1
Project status: CLOSED

This project will study the interplay between structure and dynamics in soft matter. Soft materials are of great practical importance and are ubiquitously present in our daily environment. We will focus on network-forming liquids (NFLs), which are part of the general class of complex fluids characterised by an inherent coupling between their structure and dynamics. NFLs display the strikingly cooperative dynamical behaviour found in many different materials and will be used as a paradigm of complex dynamical behaviour in soft matter. We wish to obtain a microscopic understanding of heterogeneous dynamics, dynamical arrest at the gelation and glass transitions, and nonlinear rheological properties such as shear-thickening, shear-thinning, rheochaos and fracture dynamics. The coupling of structure and dynamics in NFLs suggests that a fundamental link can be made between microscopic mechanisms and complex dynamical behaviour. We will use simulations to study a simple model system, originally devised experimentally, composed of meso-particles in a water solvent linked by polymers. Data can be obtained using advanced numerical simulation techniques, capable of bridging the broad time and length scales involved in this system. A number of different, complementary techniques will be employed including analysis of the potential energy landscape, network analysis and constraint theory, drawing on analogous studies of glassy systems. With this simple model, we will bring together different (and sometimes contradictory) perspectives of slow dynamics in disordered condensed matter, offering a global, coherent microscopic understanding of dynamic heterogeneities and other anomalous dynamical properties in NFLs. This project provides a vital stepping stone for the researcher to forge an independent career, enhancing her research skills with broad interdisciplinary expertise and supporting her career development, through structured training in research and complementary skills.

Keywords: soft matter and polymer physics,statistical physics,relaxation,computational physics,gels,glasses,heterogeneous dynamics,potential energy landscapes
Identification of genetic determinants involved in Streptococcus pneumoniae pathogenesis (TN-SEQ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-05-01
End date: 2013-04-30
Duration (months): 24.0
Total project cost (EUR): 184540.8
EU funding (EUR): 184540.8
Participants: 1
Project status: CLOSED

Respiratory tract infections are a leading cause of global mortality and morbidity. It has been estimated by the WHO that annually 4-5 million people die of pneumonia. Streptococcus pneumoniae, aptly named because it is the most important bacterial cause of pneumonia, is likely primarily responsible for these deaths. Infection by S. pneumoniae is a complex process dependent on a number of essential pathways, of which members could form ideal candidates for drug design. To identify microbial genes required for pathogenesis, we plan to use an insertion knockout strategy that allows rapid identification of disrupted genes. The host lab successfully performed micro array based approaches and proof-of-concept next generation sequencing methodologies to determine which genes are essential under a number of relevant in vitro and in vivo conditions. To identify shared essential pathways we will use statistical analysis, pathway analysis, network reconstruction and functional category enrichment methods on existing data and data generated within this project to determine the most ideal candidates for drug design. These key genes do not necessarily have to be detected initially in all screenings because of the noise inherent to the techniques used or limited survival of the mutant library. Genes coding for products with the appropriate characteristics will be subsequently tested in an animal model. Vaccines and novel drugs generated from this approach will provide alternatives to continue treatment and prevention of life-threatening chronic and acute bacterial infectious diseases.

Keywords: pneumonia,meningitis,streptococcus,pathogenesis,microarray,next generation sequencing,bioinformatics,network reconstruction,pathway analysis,vaccines