Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multilingualism or Relative Engagement (MoRE): Neurocognitive Outcomes Beyond Bilingualism (MoRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

This project aims to elucidate whether and how true multilingualism would induce different neurocognitive adaptations from bilingualism. While it may be intuitive to think that managing more than two languages would result in further and/or distinct adaptations, limited available research on multilingualism suggests that any deviation from the bilingual adaptation trajectory may be due to differences in processing and control demands. It is unclear if multilingualism inherently leads to distinct neurocognitive adaptations, or whether differences between bilingual and multilingual engagement only emerge when the control demands on the relevant cognitive mechanisms required in specific cases of multilingualism surpass those of bilingualism. Furthermore, existing research on the neurocognitive effects of multilingualism is scarce and often conflates bilingual and multilingual participants and/or overlooks the effects of engagement. MoRE addresses this gap by comparing three groups of bilingual and multilingual individuals with varying degrees of language engagement, serving as proxies for different control demands. Employing a multifaceted approach, MoRE will incorporate a comprehensive language background questionnaire and combine cognitive behavioural tasks with electroencephalography (EEG) recording. The use of EEG methods to explore multilingualism-induced neurocognitive adaptations remains relatively understudied, positioning MoRE among trending work in the field in demonstrating how cognitive mechanisms calibrate to meet the demands involved in managing more than two languages. MoRE thus seeks to underscore the importance of considering variability in multilingual engagement in brain and cognition studies, and guide stakeholders in facilitating greater diversity and intensity of multilingual engagement practices for broader societal benefit.

Keywords: bilingualism,multilingualism,neurocognitive adaptations,eeg,executive function
Modelling of fracture in soft biological tissues (BIOFRAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-16
End date: 2025-12-15
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Blood vessel rupture in brain aneurysm is fatal in 40% of cases; vision loss initiated by Retina Pigment Epithelium rupture affected 60 million people in 2020. This proposal establishes new approaches to simulate these systems and the fellowship develops a unique skillset to solve problems involving tissue fracture, having major impact on future medical intervention. Soft tissues are essential in our body and their failure to maintain mechanical integrity leads to diseases. Despite its importance, present understanding of fracture in tissues is limited. Fracture significantly alters the mechanics of tissues and experiments alone are unable to disentangle the interacting processes occurring concurrently at the crack tip and in the bulk material. Hence, a mathematical approach is needed to understand how fracture propagates at cell level up to failure. Models that account for all the complex processes that occur during fracture are still missing. BIOFRAC aims to develop an accurate numerical model of tissue fracture by adopting an innovative micromechanical approach—supported by laboratory and clinical experiments—to account for the multi-physical complexities by means of a novel constitutive relationship. This approach will allow us to predict crack evolution up to catastrophic failure. BIOFRAC focuses on the study of a single layer of epithelial cells—a simple yet clinically relevant tissue that lines many organs. Using this system, BIOFRAC seeks to uncover the biophysical and mechanical processes that control fracture initiation and propagation. The approach will then be used to address ophthalmological problems by development of a novel computational model for Retinal Pigment Epithelium able to quantify the risks of fracture during Age-related Macular Degeneration treatment. BIOFRAC will stimulate more studies of disease evolution and novel therapy. The new skills will boost my career by placing me at the forefront of tissue failure research.

Keywords: biomechanics,fracture,viscoelasticity,fractional calculus,soft tissues,biophysics
Autonomous Networked Wireless Power Transfer for Zero-Energy 6G Massive Internet of Things (MILESTONE-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

The advent of 6G technology is set to revolutionize global connectivity, expanding the Internet of Things (IoT) to an unprecedented scale. Trillions of interconnected devices will transform sectors like healthcare, agriculture, industry, and smart cities. However, this rapid growth poses significant challenges, particularly in achieving the United Nations Sustainable Development Goals (SDGs). A major issue is the "trillion-battery problem", which threatens sustainability due to frequent battery replacements, data gaps, and environmental risks. Addressing these challenges is essential for the successful deployment of 6G IoT networks. This project, "autonoMous networked wIreLEsS power Transfer for zerO-eNErgy 6G massive IoT (MILESTONE-6G)," aims to advance zero-energy device technology, which eliminates the need for batteries by harvesting ambient energy. These devices offer a sustainable alternative, reducing electronic waste and contributing to global sustainability (UN SDG 7) and innovation (UN SDG 9). However, critical challenges remain, including the need for self-adaptive power scheduling and secure wireless power transfer. MILESTONE-6G addresses these challenges through two key research goals: developing self-adaptive scheduling techniques for networked wireless power transmitters and creating robust defense mechanisms against malicious energy attacks. This multidisciplinary project will leverage cutting-edge technologies, including edge computing and intelligent reflective surfaces, supported by robust theoretical frameworks like communication and optimization theories. Aligned with global priorities in 6G development, MILESTONE-6G supports the European Union's goals, including the Horizon Europe's Pillar II, Zero Pollution Action Plan 2050, and the European Green Deal-Fit for 55, supporting a climate-neutral Europe by 2050. This project promises a sustainable, secure, and interconnected future, making it a vital scientific investigation for global progress.

Keywords: 6g,zero energy devices,internet of batteryless things,self adaptive power scheduling,secure wireless power transfer
Diversity of bacteriophages in the ancient human microbiome (ARCHAIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: CLOSED

While recent work has begun to shed light on the microbiota, which includes the trillions of bacteria and phages that inhabit our body, our understanding of its evolution over the course of human history is limited. To answer research questions regarding the development of the human microbiota over time, researchers have begun to sequence ancient DNA from well-preserved fecal and dental samples to understand their bacterial community composition. However, an important group of the microbiota, bacterial viruses (or bacteriophages), which play a large role in influencing bacterial community structure and can affect human health and disease, are often understudied in these ancient samples. Here, we propose ARCHAIC (bActeRiophage in the anCient HumAn mICrobiome), a project which aims to answer key questions regarding these important viral populations in these ancient samples. Using an integrative and collaborative approach, we will use sequencing data of ancient paleofeces and dental calculus to study the oral and gut microbiome from a variety of time periods. This novel work will allow us to develop a pipeline to identify viruses in ancient samples and answer the question - do ancient bacteriophage populations resemble modern ones? In addition, by identifying phages in these ancient samples, we will be able to probe the sequencing data for insights on phage evolution, the development of bacterial defense systems against phages, as well as reconstruct ancient phage genomes to identify novel phage/host pairs. ARCHAIC will move the field of phage biology forward by identifying phages in these relatively understudied ancient samples and will have results that will be applicable to the fields of bacterial evolution, anthropology, and bioinformatics.

Keywords: metagenomics bacteriophage ancient dna paleogenomics
Southern Ocean fine-scale ocean dynamics and storm impacts on air-sea heat exchange (SOFIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 2479552.5
EU funding (EUR): 2479552.0
Participants: 1
Project status: SIGNED

Climate mitigation relies on accurate knowledge of Earth’s energy distribution, which informs us about the extent, rate, and locations of climate warming. Historically, the ocean has played a dominant role, absorbing 93% of the excess heat generated by human activities through the air-sea interface. Ocean heat content trends obtained from sparse observations show the Southern Ocean dominates this heat uptake. Climate models confirm this, indicating the Southern Ocean accounts for 75–83% of the global ocean heat uptake. However, inter-model comparisons show discrepancies in ocean heat uptake by 40% that arise from misrepresentation of high-latitude winds and poor parametrization of vertical heat transport induced by fine-scale (1–100 km) ocean circulation. The goal of SOFIA is to understand and quantify the dominant processes that are responsible for moving heat between the atmosphere and ocean interior, thereby advancing climate understanding and predictability. I hypothesize that the ocean-atmosphere heat exchange across the Southern Ocean is set by immense and turbulent storms, while the vertical transport of heat between the surface ocean and interior is strongly regulated by fine-scale ocean fronts, eddies and filaments located in regions of high eddy kinetic energy. I will investigate the role of these processes in heat exchange dynamics by integrating a state-of-the-art coupled ocean-atmosphere model simulation with novel in-situ data from the remote Southern Ocean using innovative autonomous ocean observing technologies. Using high-resolution ocean altimetry data from the newly launched Surface Water Ocean Topography (SWOT) satellite mission, I will reconstruct circumpolar maps of vertical ocean transport, advancing our global understanding and predictability of ocean heat uptake in response to climate variability and change.
Development and characterization of a pan-flavivirus vaccine candidate (FLAVIVACCINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Netherlands,Spain,Norway,Italy,United Kingdom,Portugal,United States
Call: Pandemic preparedness and response: Immunogenicity of viral proteins of viruses with epidemic and pandemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 8269919.0
EU funding (EUR): 8269919.0
Participants: 11
Project status: SIGNED

Dengue, yellow fever, Zika, and West Nile viruses are mosquito-borne flaviviruses and global public health burdens that infect half a billion people annually, causing 250,000 deaths, and threaten nearly the entire human population. In a context of human-driven global changes, these threats will intensify with larger and more frequent epidemics, potentially leading to pandemics, will expand with geographic spreading of the mosquito vectors, and will multiply with the likely emergence of yet-unknown flaviviruses. Improving pandemic preparedness and response to these emerging and re-emerging diseases is a top priority both for the EU and WHO. However, there are no effective interventions against all flaviviruses and current vaccines targeting flaviviral proteins have severe safety issues. FLAVIVACCINE’s high-impact/low-risk/disruptive ambition is to develop a novel, broad-spectrum, mosquito saliva-targeted vaccine candidate that protects against multiple different flaviviruses and is ready for clinical evaluation by building upon an experimentally-validated proof-of-concept. FLAVIVACCINE will define the immunogenicity of the pan-flavivirus target, develop and characterize a vaccine candidate against multiple flaviviruses, and prepare it for clinical evaluation. To reach these goals, FLAVIVACCINE creates a unique interdisciplinary environment of ten public and private institutions, including Universities, Research Institutions and a Vaccine Developer, from seven countries to cover all the required scientific expertise and knowledge in cell biology, virology, immunology and vaccinology. The pan-flavivirus vaccine candidate that will be validated against dengue, yellow fever, Zika and West Nile diseases in several preclinical models, together with the knowledge and networks resulting from FLAVIVACCINE, will have short- and long-term impact on the EU ability to combat epidemic and pandemic viral threats, and protect communities and citizens in the EU and around the world.

Keywords: flavivirus,mosquito saliva,vaccine development,animal models,pandemic preparedness,broad spectrum vaccine
The Micro-Level Effects of Civil Wars on Multiple Dimensions of Women's Empowerment (WarEffects)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2028-08-31
Duration (months): 72.0
Total project cost (EUR): 1784229.0
EU funding (EUR): 1784229.0
Participants: 1
Project status: SIGNED

WarEffects aims to advance a systematic, nuanced, and rigorous understanding of how civil wars affect women’s social and political empowerment at the local level. Recent quantitative research suggests that civil wars promote women’s political representation, but these accounts reflect country-level aggregate measures and often focus on a minority of political ‘elite’ women. Thus, they do not inform us how subnational and individual-level variation in civil war experiences affect the majority of ‘non-elite’ women at the local level. To address this challenge, I propose a novel theoretical framework that simultaneously explores the effects of civil wars on i) multiple dimensions of women’s empowerment in the household and family, the community, and local politics. Moreover, I introduce ii) nuanced definitions for different types of exposure to civil wars, iii) the difference between changes in gender roles and gender attitudes, and iv) the moderating effect of context conditions. Building on the variation of each of these four dimensions allows me to generate a large set of hypotheses to advance a systematic and nuanced understanding of when, why, and how civil wars promote women’s empowerment, and when they do not. To empirically explore these hypotheses, I will combine novel quantitative survey experiments and qualitative research in Colombia, DR Congo, and Sri Lanka. While each country case has experienced several decades of civil war, there is significant within-case and between-case variation in social context, conflict dimensions, patterns of violence, and conflict status, rendering them ideal for exploring the local effects of civil war violence on women’s empowerment. Drawing on this comparative design will allow me to make statements about common patterns, divergences, and conditional effects. Altogether, this wealth of findings will establish a new conceptual and empirical research platform on the impact of civil wars on gender relations.

Keywords: civil wars,women s empowerment,quantitative,survey experiment,micro level
Multi-hazard Infrastructure Risk Assessment for Climate Adaptation (MIRACA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Netherlands,Greece,Slovenia,Spain,United Kingdom
Call: Towards asset level modelling of climate risks and adaptation (HORIZON-MISS-2021-CLIMA-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2050000.0
EU funding (EUR): 2050000.0
Participants: 7
Project status: SIGNED

Europe’s critical infrastructure (CI) is at risk of failure due to natural hazards and rapid climate change, which can lead to major physical and economic damages. Existing methods for climate risk analysis are not tailored to the complexities of CI: they do not properly account for systems interdependencies, while also still containing key data gaps. Public authorities urgently need tools to pinpoint the risk-prone areas and to develop affordable adaptation strategies to enhance CI resilience. The mission of the Multi-hazard Infrastructure Risk Assessment for Climate Adaptation (MIRACA) project is to catalyse and empower the implementation of adaptation measures for CI throughout Europe. The MIRACA Consortium will develop an evidence-based decision-support toolkit, consisting of (i) a guidance on technical and economic appraisal of adaptation strategies, (ii) a technical decision-support workbench and (iii) an online interactive viewer. These will be based on a multi-hazard climate risk assessment framework that employs advanced new methods of data acquisition, which will fill critical gaps in knowledge of the vulnerability and costs of CI. New model capabilities will be developed to fully appraise the benefits for people and businesses of climate-resilient infrastructure systems. We will demonstrate, validate, and promote the uptake of MIRACA’s research and innovation through five use cases. They cover a variety of locations, infrastructure types and natural hazards, and will allow public authorities and CI managers to test the effectiveness of adaptation solutions and to identify robust adaptation strategies. To propel transformative change, our methodologies will be made available through open-access datasets, model codes and online interactive visualisations. The toolkit will be implemented across Europe, most notably in regions and communities that are currently not well-prepared against future climate change and still confronted with data scarcity.

Keywords: critical infrastructure systemic risk decision support,multi hazard
Shaping Healthy Immune Early Life Dynamics: role of the virome in undernutrition (Virome-SHIELD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

Nearly half of all deaths in children under five are linked to undernutrition, which causes developmental issues and increased susceptibility to infections and intestinal inflammation that are not fully corrected by traditional nutrition strategies. Early exposure to commensal bacteria shapes immune trajectories, influencing susceptibility to infections and inflammatory diseases both early in life and in the long-term. Reseach from the host laboratory has demonstrated that commensal bacteria contribute to host development, particularly under conditions of undernutrition. Similarly, commensal viruses (aka the virome) can modulate immune responses. Infants, especially in regions with high rates of undernutrition, are highly exposed to these viruses. However, the virome’s impact on immune development and its contribution to the effects of undernutrition remains largely unexplored. Building on my experience working with a commensal murine enteric virus, I aim to investigate how early immune imprinting by the virome alters host-development trajectories —including growth, metabolism, and sexual maturation—and affects long-term susceptibility to infections and inflammatory diseases in male and female mice. Using a combined approached of hypothesis-driven research (focusing on the homeostatic role of type I interferons) and a RNA sequencing-based discovery, this study will uncover unknown physiological functions of immune cells that are critical in challenging environments like undernutrition. The findings from this study will provide new insights into how understudied factors—such as the virome, sex, and undernutrition—affect immune function, including host-defenses and physiological functions. This knowledge could lead to innovative preventive and therapeutic strategies for undernourished children, such as microbiota-targeted food and immune-based interventions, tailored specifically for boys and girls.

Keywords: microbiome,virome,mucosal immunology,development,juvenile,infant,undernutrition,sex,interferon,environmental enteric dysfunction