Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rationally-designed Turbo reagents for Innovative Organometallics (RATIO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: CLOSED

This project aims to study the structure, dynamics, and reactivity of prominent alkali and alkaline-earth organometallics species by ab initio and multi-scale computational approaches. Main group organometallic compounds are cheap and mostly non-toxic; therefore, they are appealing to industrial processes and are employed today in an ever-growing list of reactions, including drug synthesis or fertilizer manufacturing. In fact, little is known about their molecular structures in solution and the mechanisms by which they react, hampering the development of more efficient reagents or experimental conditions. This is due to their highly fluxional nature, yielding a diversity of structures in fast equilibria controlled by the solvent. Ab initio molecular dynamics offers the best way to investigate these systems, as demonstrated by recent studies unveiling the structure of a pure Grignard reagent and its reaction with carbonyl substrates in a THF solution (Peltzer et al, JACS 2020). This project expands the horizon over considerably more challenging and intriguing members of the Grignard family, formed by mixing metals species or solvents, which show unexplained synergistic effects on reactivity and selectivity. First, the project will characterize the structures and reactivity (Mg-C bond formation) of mixed Mg/Li turbo-Grignard and turbo-Hauser reagents in solvent. Then, attention will be drawn on the recently discovered remarkable synergy produced by running the Grignard reaction in non-miscible mixture of organic and green deep eutectic solvents. By understanding the role of the mixed solvents for these reactions, the project aims to open the route for the design of cheaper and environmentally friendly experimental conditions. The project, carried out in collaboration with an international experimental leader will have a great positive impact on the applicant's career identifying him as one of the key players in the development of green efficient main group chemistry.

Keywords: main group metals,grignard reagents,ab initio molecular dynamics,density functional theory
Green-health-safety Nexus for new Urban Spaces (GreeNexUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Netherlands,Belgium,Greece,Portugal,Sweden,Norway,United Kingdom,Spain
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2737982.06
EU funding (EUR): 2633666.4
Participants: 20
Project status: SIGNED

In our increasingly anthropised planet, many cities are facing multiple societal and environmental challenges and the link between the characteristics of the urban green contexts and people’s health and safety represents an emerging topic and of urgent importance. Air pollution and urban climate, reduced contact with nature, limited access to quality green spaces, and urban fabrics and infrastructure that discourage sustainable&safe mobility and active lifestyles, are threatening the mental and physical well-being of an aging society and increasing its social disparities. The GreeNexUS project proposes a novel and multidisciplinary approach to promote urban greening, territorial regeneration and safety/accessibility/walkability of urban infrastructures, as key strategies to face those challenges, while addressing climate change and preventing pandemics from exacerbating inequalities in disadvantaged/vulnerable groups. The GreeNexUS participants (20 institutions from 9 European countries) are joining forces to offer a collaborative Training-through-Research programme involving universities, research centres, companies, NGOs, and local authorities that share this new vision of fostering greener, healthier and safer urban realms of Europe’s cities and towns. This will drive the GreeNexUS process to train specialists, whose cutting-edge and intersectoral expertise will be developed and managed through a challenging general programme of training that combines and integrates the various fields of innovative knowledge of the GreeNexUS’ participants, and also includes career planning, entrepreneurship and soft skills training. In terms of research, 10 specific and multidisciplinary topics will be addressed by 10 Doctoral Candidates, who are envisaged to spread the GreeNexUS approach beyond the project’s scope and duration, under the guidance of a supervisory group of academic and non-academic experts.

Keywords: green urban areas health and wellbeing green regeneration and planning sustainable design accessibility and safety vulnerable users safe shoes and walking aids sustainable pavements and maintenance
FORALIEN: towards the development of a foraminiferal Non-Indigenous Species index (Foraminiferal aliens)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 2
Project status: SIGNED

FORALIEN (FORaminifera ALIEN) is a project aiming to fill the lack of knowledge of non-indigenous (i.e. alien) benthic foraminifera (marine protists) observed recently in Europe to make them a reliable indicator of human impacts for a better integration into biomonitoring surveys in the context of the European regulation of the Marine Framework Strategy Directive. To do so, I plan to sample surface sediment and sediment cores of several sites on the West Swedish coast which are composed of understudied harbours, in terms of foraminifera but known places of pollution and introduction, and fjords where some have been recently observed, such asTrochammina hadai and Nonionella sp. T1. Among those NIS, Ammonia confertitesta could also occur there. This species has been recently identified as a pseudo-cryptic species included in the Ammonia tepida morphotype with two other very morphologically similar species, A. aberdoveyensis and A. veneta, that are native species in Europe. In a first place, I will morphologically identify these NIS by defining easy criteria of identification and apply a recently developped method allowing an easy identification of the three species of the A. tepida morphotype. To complement the morphological method I will apply novel methods, genetic (digital Polymerase Chain Reaction) and deep learning models, to identify NIS foraminifera quickly and reliably assess their efficiency in biomonitoring surveys. Secondly, I will use methods precedingly described and sediment samples to analyse the spatio-temporal distribution and time of arrival of NIS in the region. This would result in the development of a NIS index to asses their impact on native species. Finally, environmental parameters will be measured to define the unknown ecological requirements of NIS to better integrate them in traditional foraminiferal biotic indices used to assess the health of ecosystems and to explain and forecast their possible succesful invasions in Sweden.

Keywords: non indigenous species,benthic foraminifera,identification methods,bio invasions,ecological requirements,biotic indices
Biogenic Solar Thermoelectric Conversion – BiSTeC (BiSTeC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Advances in green energy materials and technologies are mandated by low-carbon energy policies. Clean energy harvesting, conversion, and storage from the sun and waste heat is viewed as a major player to tackle environmental issues and energy shortages. A solar thermoelectric generator (STEG) collects solar energy & converts it into electricity using the principles of the Seebeck effect. Among the biogenic polymers applied to STEG, cellulose-based composite phase change materials (PCM) stand out since the 3Ddirectional cellulose-based composite structure provides ideal energy storage and improves heat transfer pathways. However, they still feature issues related to the low absorption coefficient, limited thermal conductivity, and low self-stability (storage and mechanical stress). Design of BiSTeC promises enhanced cellulose-based PCMs merging i) fluorescent proteins (FPs) to simultaneously enhance solar energy absorption and photo-induced heat generation, ii) nano-carbon additives to enhance heat transport, and iii) Synergic effect of cellulose, FPs and nanocarbon boost output stable performance of PCM based STEG. My expertise in the synthesis and enhancement of thermal properties of nanocomposite PCM and the host supervisor's expertise (Prof. Costa at the Technical University of Munich – TUM) on fluorescent protein (FP)-polymer coatings for photon-manipulation could provide an innovative twist in the field (design of efficient biogenic PCM based BiSTeC devices).

Keywords: composite phase change materials,cellulose,fluorescent proteins,solar energy storage,thermoelectric conversion
DYNAmics of CrossOver designation (DYNACO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1562501.0
EU funding (EUR): 1562501.0
Participants: 1
Project status: SIGNED

Meiotic crossovers make us unique. Their distribution along chromosomes dictates which traits will be reassorted to create new and unique allele combinations on which selection can act. Early during meiosis, a large number of recombination interactions are initiated all across the genome, but only a few ultimately mature into crossovers. The final number and positions of crossovers are tightly regulated: along each chromosome, crossovers tend to be evenly spaced. This phenomenon, called crossover interference, was discovered in 1914 by Sturtevant and Morgan while drawing the first recombination map in flies. Emergence of spatial patterning requires communication. But how does the crossover formation machinery communicate with neighboring crossovers half a chromosome away? Our understanding of how this communication is established has been hindered by the limited resolution in time provided by classical cytology, giving us access to only snapshots of the process. In the DYNACO project, I will develop innovative solutions to explore the dynamics of crossover designation and interference. Using gentle live super-resolution microscopy combined with groundbreaking genetic and optogenetic tools in a very amenable system, the filamentous fungus Sordaria macrospora, I will address the following questions: (i) How do pro-crossover factors behave dynamically to enact and respond to crossover interference? (ii) What is the medium supporting crossover communication? (iii) What are the consequences of locally disrupting this communication? The DYNACO project will provide fundamental breakthroughs in our understanding of crossover formation, designation and interference. We will confront and reconcile many aspects of current models for crossover interference, and develop our own unified model. This work also has the potential to provide tools for the manipulation of recombination, to accelerate the introgression of selective traits into elite crop genomes.

Keywords: meiosis,recombination
Super Living Labs for Integrated peri-urban areas in the transition towards climate neutrality (ALTHEA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Italy,Netherlands,Belgium,Portugal,Spain,Greece,Germany,Poland,Denmark,France
Call: Integrated peri-urban areas in the transition towards climate neutrality (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 10806953.25
EU funding (EUR): 8994624.94
Participants: 38
Project status: SIGNED

ALTHEA aims at putting peri-urban areas at the core of the transition to climate neutrality following the successfully tested Transition Super Living Lab approach, as dynamic testing grounds for systemic change, that provides a new cross sectorial model to support peri-urban areas on achieving the change towards climate neutrality through innovation and digitalisation. ALTHEA will help Mission Cities to develop and implement cross sectorial innovative solutions aligned with their Climate City Contracts (CCC) and build up strategies and Local Green Deals that integrate the urban and peri-urban area in a symbiotic environment having mutual benefits. Through a multi-level governance approach, ALTHEA will empower five TSLLs (Antwerp-Rotterdam, Milan metropolitan region, Alicante- Elche Functional Area, Epirus-Ioannina region and Lisbon metropolitan region) and three replicator sites (Greater Copenhagen, Gdynia and Aachen) to implement 59 targeted interventions addressing four key innovation axes: sustainable mobility, decarbonized energy systems, zero-pollution industry, and cross-sectoral governance. To support this systemic transformation, ALTHEA will design and develop 21 cutting-edge and data-driven innovations, forming the ALTHEA Innovations Toolkit. These solutions will optimize transportation networks, decarbonize energy grids, enhance governance structures, and improve industrial sustainability. By bridging governance gaps, strengthening institutional capacity, and leveraging data-driven solutions, ALTHEA will position peri-urban areas as key drivers in Europe’s climate-neutral future. ALTHEA methodology and impact will be evaluated in different functional peri-urban areas: i) Cross country, ii) cross region iii) cross city and iv) city and peri-urban area, maximising its replicability potential.

Keywords: climate city contracts transition to climate neutrality transition super living lab tsl local green deals adaptive governance industry and society cross sectoral systemic change
Typical and Atypical structures in quantum theory (TAtypic)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2253125.0
EU funding (EUR): 2253125.0
Participants: 1
Project status: SIGNED

Quantum theory, confirmed in numerous sophisticated experiments, is widely believed to describe our world at the micro scale. It is thus legitimate to investigate, which structures are allowed by quantum theory, and which of them can potentially be relevant for developments of quantum technologies. The basic notion of a quantum state – a mathematical tool used to compute probabilities, characterizing the outcomes of a quantum measurement – is of a primary importance. Furthermore, one analyses quantum maps, which describe how quantum states evolve in time, and quantum supermaps, representing evolution in the space of quantum maps. Assuming that the number of outcomes is finite, all these sets form convex bodies embedded in a real space of a suitable dimension. The case, if the physical system is composed of several subsystems, is of a special interest, as one can analyse correlations and entanglement between subsystems. Main goal of this project is to investigate properties of typical quantum states, maps and supermaps, and to identify distinguished, atypical structures with extreme properties, useful for processing of quantum information. We will search for new constructions of absolutely maximally entangled multipartite states, which imply existence of quantum error correcting codes, novel schemes of mutually unbiased bases and symmetric informationally complete generalized quantum measurements, which offer optimal measurement accuracy. Moreover, we plan to analyze quantum supermaps with distinguished properties, and study, how these structures behave under decoherence, as quantum features become gradually suppressed. To put all these structures of the same footing we are going to use generalizations of the Choi-Jamiołkowski isomorphism, which relates quantum maps with quantum states of the extended system, and apply the theory of random matrices to elucidate differences between typical objects with generic features and the atypical ones with desired properties.

Keywords: quantum entanglement,quantum information,quantum combinatorics,random matrices,quantum maps
Technologically mediated landscapes: Examining the adaptive benefit of the early Oldowan. (OLAF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Tool production is intrinsically tied to the evolution of our species as it allows us to occupy nearly every environment on the planet. The widespread production of sharp-edged tools known as the Oldowan, 2.6 million years ago, is regarded as a major adaptive leap as it may have fundamentally changed the ecology of our ancestors. This major adaptative shift resulted in a change in diet, enhanced ecological versatility for a range of environments, and, ultimately, the proliferation of the human lineage across the globe. However, it remains unclear if the emergence of Oldowan technologies resulted from a watershed innovation or if it represents a technological continuity of the tool repertoire of apes. The OLAF project aims to determine the adaptive significance of the appearance of the Oldowan by implementing a new set of theoretical tools while shifting the scale of archaeological analysis from the site to a broader landscape level. OLAF will use agent-based modeling to directly investigate the relationship between stone tool use, environmental factors, and site formation processes at the landscape scale and generate concurrent expectations for how hominin-environment interactions produce patterns in the archaeological record. In parallel, we will reconstruct the portions of the Ledi Geraru (Ethiopia) research area where sediments have preserved the 2.6-million-year-old artifact and fossil-rich paleolandscape, over an area of 33 square kilometers. Agent-based models that are tailored to local data, will validate, or reject predictions concerning mobility, diet, or space use. OLAF will thus provide a comprehensive understanding of the tool-mediated foraging behaviors of the earliest Oldowan tool makers, allowing us to examine the adaptive benefits of tool use at the dawn of humanity.

Keywords: landscape archaeology,computational modeling,early stone age
Noah Labs Vox – Novel Voice-Based Heart Failure Remote Monitoring Solution (NL Vox)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Heart failure (HF) is a chronic and life-threatening disease that impairs the heart's ability to pump blood, leading to high hospital admission rates and substantial costs for health systems globally. Managing HF is challenging due to the rapid deterioration of patients, leading to decompensation and hospitalization. Effective HF management aims to avoid hospitalizations through frequent monitoring and timely medication adjustments, as up to 64% of HF hospitalizations are avoidable. The existing HF monitoring methods—manual weight monitoring, telemonitoring programs, cardiac implants, and pulmonary arterial pressure devices—are inadequate. They fail to reduce hospitalization rates on a large scale, either due to imprecision, delayed detection of worsening HF, or invasive nature. As a consequence, HF patients face high re-hospitalization rates (83% hospitalized within five years), reduced life expectancy (≈50% die within five years), high costs (≈€25K), and low quality of life due to frequent hospitalizations. Healthcare providers struggle with the high-cost burden (exceeds €100Bn/year), inability to conduct timely monitoring, and lack of scalable solutions. Noah Labs introduces NL Vox, a novel patented Digital Medical Device (DMD) revolutionizing heart failure (HF) management. Utilizing AI-based voice monitoring for the first time, NL Vox detects HF decompensation up to 21 days before conventional methods, offering accurate, early worsening HF detection comparable to invasive solutions. This enables timely medication adjustments, potentially reducing hospitalizations by >33%, mortality rates by >10% of existing methods, and healthcare costs by more than 30%. The objective of the EIC project is to enhance our AI model and conduct two trials with voice samples from HF patients. Additionally, we will optimize the user interface, integrate with telemonitoring devices, and implement explainable AI techniques.

Keywords: heart failure,heart failure decompensation,heart failure management,ai based voice analysis,voice biomarkers,deep learning,digital medical device,remote patient monitoring,cardiology