Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design Principles of Branching Morphogenesis (Demos)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1452604.0
EU funding (EUR): 1452604.0
Participants: 1
Project status: SIGNED

Branching morphogenesis, the process by which branched organs such as the lung, prostate, kidney or mammary gland are generated, is a paradigmatic example of complex developmental processes bridging multiple scales. The mechanisms through which given molecular signals and cellular behaviours give rise to a robust organ structure remains a fundamental and open question, for which theoretical methods are needed. Our experience in modelling cytoskeletal mechanics, stem cell dynamics and branching processes puts us in a unique position to tackle this fascinating problem, by combining systems biology and biophysical approaches at multiple scales. In particular, we will focus on: 1. Understanding how stochastic rules lead to robust morphogenetic outputs at the organ scale, and which constraints and optimal design principles they impose on physiological function. 2. Characterizing at the cellular scale the bi-directional feedbacks coordinating fate choices of stem/progenitor cells and niche signals during the extensive remodelling events that branching morphogenesis entails. 3. Developing at the subcellular and cellular scale an integrated mechanochemical theory of pattern formation in branched organs, to understand the coordination of mechanical forces and chemical signals defining their global structure. Towards these goals, we will combine analytical and numerical tools with data analysis methods, to reach a quantitative understanding of the emergent mechanisms driving branching morphogenesis. We will challenge our theoretical predictions with published datasets available for different organs, as well as design specific experimental tests in collaboration with experimental biology groups. This will allow us to compare and contrast different systems, and extract generic classes of design principles of organogenesis across length scales. With this, we expect to generate novel insights of broad relevance for the fields of systems, computational and developmental biology.

Keywords: systems biology,theoretical biophysics,branching morphogenesis,pattern formation,cytoskeletal force generation,cellular fate choices,robustness,developmental biology
Programmable edge-to-cloud virtualization fabric for the 5G Media industry (5G-MEDIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Spain,Israel,Germany,Italy,Germany,Italy,Türkiye,Greece,Greece,France,United Kingdom
Call: 5G PPP Convergent Technologies (H2020-ICT-2016-2, 2016)
Start date: 2017-06-01
End date: 2020-02-29
Duration (months): 33.0
Total project cost (EUR): 7742308.76
EU funding (EUR): 6128531.14
Participants: 15
Project status: CLOSED

The focus of 5G PPP H2020 remarkable research so far has been largely on the required advances in network architectures, technologies and infrastructures. Less attention has been put on the applications and services that will make use of and exploit advanced 5G network capabilities. 5G-MEDIA aims at innovating media-related applications by investigating how these applications and the underlying 5G network should be coupled and interwork to the benefit of both. In this respect, 5G-MEDIA addresses the objectives of 1) capitalizing and properly extending the valuable outcomes of the running 5G PPP projects to offer an agile programming, verification and orchestration platform for services, and 2) developing network functions and applications to be demonstrated in large-scale deployments, based on 3 well-defined use cases (in the areas of immersive media and VR, smart production and user-generated content, and UHD over CDN) of diverse requirements and particular interest for the consortium partners. Based on the adoption of the open innovation approach, 5G-MEDIA platform will be offered to third parties to develop, combine, verify, deploy and validate media applications by utilizing the SDK capabilities and Service Platform offerings.Finally, 5G-MEDIA plans to create an ambitious business impact with the introduction of Streaming as a Service concept, built on top of a well-defined, consortium-wide exploitation plan and supported by the complementarity of expertise of its consortium, representing key industrial sectors in the network and media domains: telecom operators (OTE, TID), cloud providers (SILO), PaaS/SaaS vendors (IBM), service providers (ENG), application developers (NETAS), broadcasters (RTVE), SMEs (IINV, NXW, IRT, BIT) and research centers (UCL, UPM, CERTH). It is highlighted that the consortium includes partners with strong and active participation in 5G-PPP programme, complemented by new but important players on the media & entertainment industry sector.

Keywords: network function virtualization,edge cloud,management and operation framework,5g networks for media applications
Novel vascular-like BBB-on-a-chip (NOVACHIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2021-09-01
End date: 2023-09-30
Duration (months): 25.0
Total project cost (EUR): 149951.25
EU funding (EUR): 149951.0
Participants: 1
Project status: SIGNED

There is great need to develop safer and more biologically relevant models for drug screening. Recent reports indicate that up to 20% of acute kidney complications can be linked to drug-induced nephrotoxicity and more than 40 molecules found to reduce Alzheimer’s Disease (AD)-related plaques in animal models were shown to be ineffective in AD patients. It is increasingly evident that both in vitro and in vivo models being used to develop drugs have a limited capacity to predict the pathophysiology of human disease, personalized response, and off-target drug toxicity. The inability to properly test drugs and treatments to diseases such as AD constitutes a risk for pharmaceutical companies and a major obstacle to overcome. This ERC PoC proposal aims to establish a practical microfluidic fabrication process capable of recreating structural and biomechanical features of native blood vessels. Specifically, we aim to develop a scalable 3D Blood-Brain-Barrier in vitro model (BBB-on-a-chip) able to provide a higher level of biological relevance than current in vitro models. The development of such a system would represent a major break-through for the pharmaceutical industry generating therapies for a variety of neurological disorders. Thanks to the ERC Starting Grant STROFUNSCAFF, we have developed a simple fabrication process that combines bioprinting and self-assembly to grow functional fluidic devices with endothelialized vessel-like capillaries (patent application in preparation). NOVACHIP proposes to a) build scalable microfluidic devices made from capillaries that incorporate relevant cells and extracellular matrix (ECM) components, exhibit tissue-like stiffness, and can be designed with specific sizes and geometries to better resemble the native BBB and b) compare it to a commercially available in vitro model as well as c) an established rat model by quantifying permeability of specific imaging biomarkers for Magnetic Resonance Imaging (MRI) technique.

Keywords: self assembly,organs on a chip,biofabrication,in vitro models,blood brain barrier
INNOVATIVE POLYMER-BASED COMPOSITE SYSTEMS FOR HIGH-EFFICIENT ENERGY SCAVENGING AND STORAGE (InComEss)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Germany,Spain,Estonia,Spain,Finland,Belgium,Greece,Greece,Belgium,Greece,Netherlands,United Kingdom,Portugal
Call: Smart materials, systems and structures for energy harvesting (RIA) (H2020-NMBP-ST-IND-2019, 2019)
Start date: 2020-03-01
End date: 2024-02-29
Duration (months): 48.0
Total project cost (EUR): 6967226.25
EU funding (EUR): 6967226.25
Participants: 19
Project status: SIGNED

InComEss seeks at developing efficient smart materials with energy harvesting and storage capabilities combining advanced polymer based-composite materials into a novel single/multi-source concept to harvest electrical energy from mechanical energy and/or waste heat ambient sources. Three Energy Harvesting Systems (EHSs) configurations will be realized through the combination of high performance piezoelectric (PE), thermoelectric (TE) and Thermo-Piezoelectric (TPE) generators and monolithic supercapacitors (SCs) to power selected wireless sensors nodes to be implemented in different IoT scenarios for Structural Health Monitoring (SHM) in buildings and aircrafts (using a new miniature wireless Fiber Optics Sensing (FOS) interrogator) and accurate location and monitoring of vehicles through GPS and MEMS sensing. Advanced concepts for efficient energy transfer will be implemented for increased energy conversion efficiency of the overall EHSs. InComEss EHSs will involve the following smart materials developments: 1) advanced lead-free PE composite-based mono-/bi-component fibres with enhanced PE characteristics up to 100ºC/250ºC for their application into single/hybrid PE/TPE generators; 2) innovative high-performance thermoplastic-based p-and n-type TE composites with enhanced Seebeck coefficients in the range from –25ºC up to 250ºC for their application in single/hybrid PE/TPE generators; and 3) printable high energy density PANI/carbon-based composite electrode materials with enhanced specific capacitance and stability for their incorporation into the monolithic supercapacitor (SC) to store the energy harvested. InComEss technologies, applications and services will impact the partners turnover by €100M after market up-take, generating more than 70 jobs and leveraging the EU economy to more than €4 billion and 12,000 employments and providing direct support to the realization of EU Digital Single Market and the wider implementation of IoT landscape.

Keywords: energy harvesting system,energy storage supercapacitor,piezoelectric,thermoelectric,generators,melt spinning,melt mixing,advanced polymer composites,fos sensors,conditioner circuit
Solar Twinning to Create Solar Research Twins (SolarTwins)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Spain,Türkiye
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 799446.25
EU funding (EUR): 799446.25
Participants: 3
Project status: SIGNED

Research and Innovation (R&I) in Concentrating Solar Thermal (CST) technologies promises global impacts through new and sustainable solutions to societal challenges. CST technologies include 1) Solar Thermal Electricity (STE/CSP), 2) Solar Heat for Industrial Processes (SHIP), 3) Solar Fuels, and 4) Clean and Fresh Water. Europe is currently a global technology leader in CST, and SolarTwins is designed to strengthen this leadership position. The Goal of SolarTwins is to Step-Up the Scientific Excellence and Innovation Capacity of the Promising Institution METU-GÜNAM's CST research laboratory through Twinning with the Leading Institutions PSA-CIEMAT and DLR. SolarTwins builds on several EU CST R&I networks and activities in which all 3 institutions are participating including EU-SOLARIS, EERA-JP-CSP, and SFERA-III. SolarTwins contains 3 Twinning Work Packages (WPs 1-3). WP1 contains cross-cutting activities including Joint Kick-Off Activities targeting stakeholders and External Training to strengthen local, regional and national R&I capacities. WP2 is dedicated to ESRs and contains 2 summer schools at METU taught be experts from PSA-CIEMAT and DLR, and exchange of METU ESRs to PSA-CIEMAT and DLR for training and research mentoring. WP3 is dedicated to developing joint research lines between METU-GÜNAM and each of PSA-CIEMAT and DLR. WP3 includes activities for METU-GÜNAM personnel at each of PSA-CIEMAT and DLR to formulate joint research lines, and METU-GÜNAM staff exchange to each of PSA-CIEMAT and DLR to develop joint research proposals. WP4 is dedicated to maximising the Impacts of SolarTwins and includes Exploitation, Dissemination, and Communication tasks, and a Final Conference. WP5 is dedicated to project management. SolarTwins is specifically formulated to lead to Joint Research Proposals that target large joint funding opportunities to increase competitive research funds to all partners, and result in more effective use of public research funds.

Keywords: solar thermal electricity,concentrating solar power,concentrating solar thermal
A Cognitive Fractal and Secure EDGE based on an unique Open-Safe-Reliable-Low Power Hardware Platform Node (FRACTAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Spain,Italy,Italy,Italy,Austria,Austria,Germany,Spain,Spain,Italy,Spain,Germany,Spain,Italy,Switzerland,Finland,Finland,France
Call: EDGE COMPUTING (H2020-ECSEL-2019-2-RIA, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 15727138.75
EU funding (EUR): 4708841.69
Participants: 35
Project status: SIGNED

The objective of this research activity is to create a reliable computing node that will create a Cognitive Edge under industry standards. This computing node will be the building block of scalable Internet of Things (from Low Computing to High Computing Edge Nodes). The cognitive skill will be given by an internal and external architecture that allows to forecast its internal performance and the state of the surrounding world. Hence, this node will have the capability of learning how to improve its performance against the uncertainty of the environment. As a result of the integration of these cognitive systems into a fractal network, there will be another intrinsic crucial advantage, emergency and adaptability, new functions will flourish through the created space of possibilities of our cognitive Systems. This complex network will transfer all those cognitive advantages to the Edge, a computing paradigm that lay down between the physical world and the cloud.

Keywords: edge computing,time critical,reliability,security,complexity
Scaling up entrepreneurial hubs to Europe (STARTUP- SCALEUP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Innovation actions
Countries involved: Ireland,Spain,Spain,Lithuania,Netherlands,United Kingdom
Call: Web Entrepreneurship (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 2286750.0
EU funding (EUR): 1996875.0
Participants: 7
Project status: CLOSED

The aim of the innovation action STARTUP SCALEUP is to build a European ecosystem around four consolidated entrepreneurial ecosystems in Spain (Cloud Incubator HUB), the Netherlands (Crosspring Lab), Lithuania (Open Coffee Club) and Ireland (The Ryan Academy) and the largest social network for startups in the European Union (F6S), in order to provide a greater range and quality of services to ambitious entrepreneurs who want to launch and grow companies focused on the Internet of Things and Services (IoTS). These four ecosystems, who have a track record and complementary strengths, will be able to support startups by enhancing the basic business skills of the entrepreneurs to strengthen the business sense of their startups,testing the soundness of technological concept and its uniqueness in the market, providing early exposure to EU market access, enabling talent matching and providing Venture Capital groups and other financiers with access to a critical mass of startups. To achieve this aim under the call topic (ICT-13-2014, web entrepreneurship), the STARTUP SCALEUP will: • Analyse which of their current services are best-in-class, assess which of these can be offered on a non-local scale and then design and implement a new service model to their entrepreneurs. • Set up an online platform for mentoring, networking and training through which the ecosystem members can share knowledge, experience, and contacts to support the startups, transcending geographical, cultural and resouce-related barriers. • Generate awareness and interest in STARTUP SCALEUP by developing a specific communication strategy that enables us to to attract the most talented startups to the ecosystem, pull in resources and publicize the activities of the ecosystem • Run two sequential acceleration programmes in order to create IoTS-based companies and the validate and readjust the STARTUP SCALEUP ecosystem and services. • Set up a dissemination plan to maximize the expected project impact.

Keywords: web entrepreneurs,incubators,accelerators,hubs,lean start up,start up,startup,innovation,iots,mobile technologies,web technologies
Tissue-wide identification of genome alterations in cancer (TWIGA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Sweden
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2631250.0
EU funding (EUR): 2631250.0
Participants: 1
Project status: SIGNED

We aim to develop the first generation of spatially resolved DNA methodologies to uncover the underlaying molecular landscape of cancer genomes in tissues. Our efforts will focus on a novel genome-wide technology to study genomic integrity in its spatial context, currently a major challenge in the field. The research program is based on developing new experimental protocols and new computational analysis methods. We aim to demonstrate the utility of the method in cancer applications focusing on prostate and breast cancer that display genomic alterations with hallmarks of multiclonality, amplifications and gene fusions. We have previously demonstrated the Spatial Transcriptomics (ST) technology to successfully resolve the transcriptomic landscapes of tissue sections in situ. This was the first demonstrated method to provide transcriptome-wide analysis in a spatial tissue context (Ståhl et al, 2016, review by Asp et al 2020). With the establishment of the technology we have been able to develop advanced computational strategies to explore spatially barcoded transcriptomes. We have, in a series of papers, demonstrated the value and impact to capture and link gene expression information to morphology. For example, we have employed our know-how in (i) cell atlas projects (Asp et al, 2019; Ortiz et al, 2020) (ii) understanding temporal aspects of neurological disease (Maniatis et al, 2019, Chen et al, 2020) (iii) deconvoluting the heterogeneity in cancer (Berglund et al, 2018, Ji et al, 2020). This ambitious proposal seeks to pioneer the use of the tools to perform tissue-wide identification of genomic alterations in cancer (TWIGA) through spatial barcoding on glass slides. This effort will enable us to, in an unsupervised manner, describe genomes in tissue sections for the first time. We are convinced that an increased knowledge of genomic alterations in situ will improve our understanding of cancer from precancer conditions to malignancy and spread.

Keywords: spatial,tissue imaging,genome wide,barcoding
Closing the Gender Gap in Leadership: Using Research to Inform Practice (WOMLEAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-08-31
Duration (months): 30.0
Total project cost (EUR): 216165.6
EU funding (EUR): 216165.6
Participants: 1
Project status: SIGNED

The lack of women in leadership is a concern raised by several multinational organizations including the UN and the European Commission. Research suggests that women’s underrepresentation is partly attributable to stereotypes regarding female leaders. Despite the persistence of these stereotypes, leadership scholars have shown that women are in fact, more skilled than men at almost all attributes that distinguish excellent leaders from average/poor ones. In an effort to lessen the gender gap in leadership, the current project seeks to solidify “the business case” for increased women in leadership, by developing and testing hypotheses to demonstrate that women’s leadership advantages result in increased customer service. Based on research on servant leadership, which focuses on altruistic values that engage followers in relational and emotional dimensions, so they are empowered to grow, I propose that servant leadership will positively relate to subordinates’ soft skill development and that this relationship will be stronger among female leaders. Further, given the research linking soft skills to customer service, I propose that subordinates’ soft skill training will mediate the relationship between servant leadership and customer service. While I will publish theoretical and empirical studies based on this research in scholarly journals, a distinctive feature of the proposal is dissemination to non-academic stakeholders. I plan to lead seminars in the business community to share the practical implications of my findings. The pinnacle of my communication efforts will be creating a Women’s Leadership Centre at USE that I will lead after the fellowship period. To prepare myself, I will carry out a secondment at an academic institution that has a diversity centre and at a non-academic organization focused on gender equality, to acquire knowledge about the pressing research issues facing European working women and to learn how to develop and sustain the centre at USE.

Keywords: leadership