Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Potency Dermatologicals (HIPODERM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2011-03-01
End date: 2015-02-28
Duration (months): 48.0
Total project cost (EUR): 838363.0
EU funding (EUR): 838363.0
Participants: 4
Project status: CLOSED

The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency drug delivery systems'. Our aim is to develop a core scientific platform from which novel non-invasive drug delivery systems can be developed and clinically assessed. At the core of this project lies the hypothesis that microneedle assisted topical drug delivery has failed to fulfil expectations because researchers have routinely over estimated the scale of permeation enhancement possible using passive microneedle treatment and also, in general, have targeted unsuitable therapeutic molecules. This project aims to address both of these issues by developing new formulation and fabrication approaches. Combining physical disruption of the stratum corneum barrier with microneedle arrays and a number of active permeation enhancement techniques (such as iontophoresis and phonophoresis) will produce a range of novel hybrid permeation enhancement systems (HPES). The project will focus on high potency therapeutics possessing low therapeutic concentrations that make only realistic demands on delivery systems. Such high potency materials are of increasing importance in therapeutics but are inherently difficult to work with because of the health and safety implications of their high activity. The project pools the expertise of a number of international partners with particular expertise in specific aspects of the approach. Three clinically interesting target areas have been identified for evaluation: 1. Locally delivered chemotherapeutic agents for the treatment of cancers of the skin and underlying tissues 2. Enhanced localised delivery of potent photosensitisers for photodynamic therapy (PDT) 3. Local and systemic delivery of therapeutic peptides

Keywords: minimally invasive medicines,microneedle devices,polymeric drug delivery,dermal translocation,chemotherapeutic agents,photodynamic therapy,therapeutic peptides
Intelligent amputee sockets employing real time advanced photonic sensors for optimum fit and pressure relief through active controls (SMARTSOCKET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium,Greece,Cyprus,Germany
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-06-01
End date: 2014-05-31
Duration (months): 48.0
Total project cost (EUR): 1290785.0
EU funding (EUR): 1290785.0
Participants: 4
Project status: CLOSED

SmartSOCKET aims at realizing an intelligent amputee socket with optimum fitting and pressure relief utilizing embedded fiber sensors for strain/shear measurement and countershear actuators for readjusting the pressure map distribution across the knee-socket interface. SmartSOCKET will be the first project addressing fiber sensing configurations in true rehabilitation and biomechanic applications, intending to exploit the advantages of real-time and high-accuracy sensing capabilities of optical fiber structures towards equipping amputee sockets with true pressure-detection and subsequently pressure-relief characteristics. SmartSOCKET’s main objectives include: a) the integration of a computational model for computer-aided socket design and manufacturing, b) the development of optical fiber-based sensors to be embedded in the socket system for providing real-time strain/shear measurements, c) the embodiment and miniaturization of the fiber-sensors and interrogation units into the amputee socket and its calibration in laboratory environment, d) the realization of a signal processing algorithm for extracting the pressure/shear distribution map along the human-machine interface and for controlling the countershear actuator for pressure readjustment prior ulcer initiation, and e) the final socket validation through extensive laboratory and clinical trials. Given its interdisciplinary and highly ambitious nature, SmartSOCKET strongly relies on the knowledge transfer between its academic and industrial partners. SmartSOCKET will evolve upon the close collaboration between highly experienced academic personnel on cutting edge fiber technology and industrial people with knowledge of the true socket system requirements. SmartSOCKET is expected to lead to a promising technology transfer platform bringing the world of photonics confronted with true biomechanic applications whilst equipping the world of rehabilitation and knee prosthetics with a powerful fiber sensor toolkit.

Keywords: photonic technology,rehabilitation,biomedical/biomechanical engineering,biomedical imaging,optical fiber sensors,fbg sensors,strain/shear measurements,prosthetics,amputee sockets
Digital Image and Video Forensics (DIVEFOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Italy,Slovenia,United Kingdom
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-06-01
End date: 2014-05-31
Duration (months): 48.0
Total project cost (EUR): 1559077.0
EU funding (EUR): 1559077.0
Participants: 4
Project status: CLOSED

This project is about transferring knowledge of image and video forensics between the academia and industry. Building on the complementary expertise of the participants, the consortium aims to pursue two major lines of investigations: Device fingerprint based forensics and hidden data based forensics. The first line of investigation requires the formulation of a set of “fingerprint” left in the images/video by the hardware components or in-built signal processing algorithms of the imaging device and involves the study of its forensic applications. The applications we are aiming for include device identification, technology/licensing infringement detection, device linking, automatic media classification, tampering detection. To guarantee the value of the these techniques, anti-anti-forensics measures will also be devised to detect/prevent removal or substitution of the fingerprint set. The second line of investigation is about the use and analysis of hidden data in the host image/video for authentication, content integrity verification, copyright protection (including ownership identification, proof of ownership, copy control, traitor tracing), and the use and detection of covert communications. Although data hiding is a relatively mature research area, their applicability in the real world is yet to be fully explored due to the fact that the security issues are often interleaved with multimedia processing issues and requires addressing. Therefore this line of research requires the formulation of specific security requirements and attack modelling for specific applications. Overall, both lines of research require a wide variety of expertise such as multimedia signal processing, computer vision, pattern recognition, machine learning, and optimisation theory. Therefore it is expected that this project will also take the soundness and applicability of these theories to a new level and lay a solid foundation for wider lasting collaborations in the related areas.

Keywords: multimedia forensics,digital watermarking,source device identification,authentication,classification,device linking
The interplay between the appetitive dopaminergic and the aversive serotonergic system in motivational control of behavior (PHARMACO-FMRI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 237911.8
EU funding (EUR): 237911.8
Participants: 1
Project status: CLOSED

The impact of reward and punishment on behavior is modulated by the neurotransmitters (chemicals that influence signal transfer between neurons) dopamine (DA) and serotonin (5-HT). This project tests a new model of the interplay between DA and 5-HT in motivational control of behavior, by studying the effects of DA and 5-HT increasing drugs on motivational learning and brain activation. Blood oxygen level dependent functional Magnetic Resonance Imaging (BOLD fMRI), a method often used to measure brain activity, is not adequate to assess drug-induced changes in brain activity. In this project new and promising fMRI techniques are used: arterial spin labeling (ASL) and calibrated BOLD fMRI. The results of this project are important for improving methodology in pharmacological fMRI research and may lead to improved treatment for psychiatric patients. The applicant will work for two years (outgoing phase) at the Center for Functional MRI, University of California, San Diego (UCSD), USA. Dr. T. Liu and his colleagues are world leading in the use and development of the abovementioned advanced fMRI techniques. Prof. M. Paulus of the Department of Psychiatry, UCSD, will collaborate on this project. During the return phase, the applicant will work at the Department of Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands, which houses experts in the field of psychopharmacology and toxicology of behavior. This collaboration results in a multidisciplinary research team of experts with excellent training records. The applicant has shown the potential to become a senior researcher. This fellowship will provide the applicant with goal-oriented training, the opportunity to develop complementary skills and to build an international network. The fellowship will make a major contribution to the applicant’s career and to the EU scientific excellence and competitiveness in the field of pharmacological neuroimaging.

Keywords: cognitive neuroscience,pharmacological neuroimaging,serotonin,dopamine,functional mri,motivation control of behavior
A multilocus approach to the phylogenetic inference of an island and continental plant radiations (PLANT SPECIATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 230247.2
EU funding (EUR): 230247.2
Participants: 1
Project status: CLOSED

Processes of species diversification, which form the basis of biodiversity dynamics, are still only partially understood. The evolutionary histories of taxonic radiations (the burst of numerous closely related species over a short period of time), have been particularly difficult to resolve phylogenetically. Recent analytical developments including new molecular markers and new computing methodologies, are providing the opportunity to unravel these striking evolutionary phenomena. Moreover, understanding the genetic variation and evolutionary history of economically important plant species and their relatives is critical for the sustainable use of plant genetic resources and for optimizing crop improvement programmes. Coffea (Rubiaceae) and Astrocaryum (Palmae) are two tropical genera that include economically important species. The aim of this project is to construct a species-level phylogeny for the Coffea species inhabiting Madagascar and a group of closely related Astrocaryum species mostly from western Amazonia and the lower eastern Andes, allowing the comparison of radiative speciation patterns in an insular or in a continental setting. Phylogenetic reconstruction will be based on the comparison and combination of three kinds of molecular markers: plastid sequences, nuclear genes and transposable elements. Most of the DNA regions to be used, generated by ongoing genomic projects for commercial palms and coffee species, are still largely unexplored in plants, and have not been used for phylogeny reconstruction to date. Phylogenetic analyses will be conducted using maximum parsimony and Bayesian criteria, methods for inferring species tree from multiple gene trees, and methods for dating phylogenies. The phylogenetic relationships and the chronologies of speciation inferred will be evaluated through models of sympatric or allopatric speciation in the biogeographical context of north-western South America and Madagascar, two major world biodiversity hotspots. The project will contribute to the applicant's progression as an independent scientist by adding strong genomic skills and high-impact publications necessary to reach a position of professional maturity in Europe. With a career move from Denmark to France the applicant complies with the mobility criteria of the programme.

Keywords: systematic botany,species-level phylogeny,speciation pattern,gene discordance,species tree,palms,coffee,low-copy nuclear genes,chloroplast,transposable element,madagascar,western amazon
Double-site ligands for the inhibition of Cholera toxin (DOUBLELICHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 172939.4
EU funding (EUR): 172939.4
Participants: 1
Project status: CLOSED

Specific binding between bacterial enterotoxins and oligosaccharides on the host cell membrane is a paradigm for protein-sugar interaction. One of the best characterized recognition pairs is formed by ganglioside GM1 and the cholera toxin (CT). Recently, Krengel´s group has identified a second binding site, which appears to be present in the close CT congener LT and in CT from the El Tor strain, responsible for the current cholera pandemic. This binding site, which is clearly distinct from the primary GM1 binding site, recognizes blood group ABO antigens, fucosylated carbohydrate structures carried on both glycolipids and glycoproteins. The main objective of our project is to develop new dual-site ligands for cholera toxin inhibition featuring 2 pharmacophoric fragments, a GM1 mimic and a blood group mimic, connected across a linker able to span the two binding sites of enterotoxins. The GM1 binding site will be targeted using a functionalized GM1 mimic recently developed in the host laboratory which binds to CT and allows conjugation to aglycons. The blood group binding site will be targeted by selecting the mimimal blood group epitope using STD NMR experiments. Linkers of different lengths will be built in modular fashion by connecting PEG monoamine fragments using squaric acid connectors. Optimal linker length will be selected by combinatorial target-guided dynamic synthesis of a disulfide library in the presence of hLTB or CTB/hLTB toxin hybrids as templates. The required proteins will be obtained through a collaboration with the Krengel group. This project is connected to the activities of the COST D34/001/05 WG, working on cholera toxin inhibition and sensing. This fellowship and the framework provided by the COST group will ensure the opportunity for the proposer to be exposed to an interdisciplinary context while working on a timely scientific project resulting from the coordinated efforts of internationally recognized research leaders in glycoscience.

Keywords: cholera toxin inhibitors,ab5 toxins,carbohydrate mimics,gm1,dynamic combinatorial chemistry,libraries,template synthesis,double-site ligands,computational chemistry,disulfide interchange,std
New Sequential Multicomponent Reactions (SEQ-MCR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 166645.6
EU funding (EUR): 166645.6
Participants: 1
Project status: CLOSED

Multicomponent reactions (MCR) have recently attracted a great deal of attention as they are considered as a kind of “holy grail” for organic chemists. Although new examples are constantly flourishing in the literature, there are a limited number of processes that allow multiple components to react together in a single operation. We propose to develop new processes involving two consecutive multicomponent reactions that would open a rapid access to biologically relevant 6-membered ring lactones and lactams. The carbon backbone will be generated using a three-component radical cascade between a xanthate, an olefin and a sulfinyl oxime, followed by the hydrolysis of the resident oxime into an aldehyde, which will be one of the partners in the subsequent multicomponent reaction. 3, 4 and 5CR-radical-, /Aldol, /Mannich and /Petasis reactions will thus be studied that should provide a large variety of lactams and lactones in a diastereocontrolled manner. An application of this strategy to the synthesis of relevant alkaloids is also proposed that should illustrate the power of sequential multicomponent reactions in organic synthesis. This conceptually novel approach should lead to valuable intermediates for organic synthesis, with high bond forming efficiency. The project is based on atom and step economy concepts, two of the most important principles of “green and sustainable chemistry”. Although yet at a fundamental level, this research has potent applications in new technologies, including synthesis automation, which is of high industrial interest. This project is also aimed at training a promising organic chemist from an emerging country, in sustainable chemistry, a fundamental objective in chemical sciences. The researcher that should develop this project has been educated in one of the best chemical institute in India, and possesses an excellent scientific background with seven years experience in total synthesis, having led to remarkable achievements.

Keywords: carbon chemistry,pharmaceutical chemistry,multicomponent processes,radical chemistry,organocatalysis,aldol,mannich reaction,petasis reaction,radical cascade,lactones,lactams
Development of new flow chemistry methodology: Application into total synthesis of spirangien natural products and analogues thereof. (FLOW-CHEMISTRY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

This is a proposal on Organic Chemistry. One of the most relevant problems in modern synthetic chemistry is the development of new technologies directed towards overcoming many of the bottlenecks associated with conventional organic synthesis. Also more use of automation is needed to facilitate scale-up and to improve the current synthesis standards. One of the most exciting and potentially significant developments is the incorporation of flow chemistry into lab based synthesis platforms. Moreover, an additional benefit to this mode of chemistry is that it allows for the linking of individual reactions into multi-step sequences, allowing for one reaction to flow seamlessly into another, creating a rapid route to the desired more complex product in gram-scale. Although this field of research is still in its infancy, the endless applications of such methodology mandate extensive research on the subject. Natural products bearing a spiroketal or bis-oxazole core structure are well-precedented biologically interesting compounds. Application of innovative flow approach to such modular total synthesis would be useful as biological probes for drug discovery programs. As a proof of the concept hennoxazoles and spirangiens have been targeted for design of novel flow approach. This will naturally lead to development of new flow chemical methodology. Particularly challenging organometallic Carbon-Carbon and Carbon-Oxygen coupling reactions are to be developed. The successful application of this proposal may allow the applicant conduct postdoctoral studies at one of the most prestigious European research centre (Professor Ley´s Group at the University of Cambridge, U.K.), therefore expediting fellow’s career development.

Keywords: carbon chemistry,organometallic chemistry,homogeneous catalysis,heterogeneous catalysis
A new logic to control signalling pathways in the mouse brain: The role of MAPK in emotional behavior (MAPKMOOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-15
End date: 2013-01-14
Duration (months): 24.0
Total project cost (EUR): 162161.0
EU funding (EUR): 162161.0
Participants: 1
Project status: CLOSED

Mood disorders represent some of the most common and proliferating health problems worldwide. The present knowledge on the molecular regulation and intracellular signalling mechanisms of anxiety and depression behaviour is incomplete. A better understanding and the development of novel, improved therapeutic treatment would fill a medical need. To study the function of signal transduction pathways in the brain requires control of the activity of a signalling protein in a temporal manner in a selected cell type of the brain. Signalling processes undergo cycles of activation and repression, such that their manipulation into both directions is of experimental interest. This project will focus on the development and application of a new inducible and reversible switch to modulate the activity of signalling molecules at the protein level in the postnatal mouse brain, with the MAP Kinase (MAPK) pathway as a case study. This switch relies on the posttranslational activation of hyperactive or dominant negative protein kinase mutants fused with the ERT2 mutant estrogen receptor ligand binding domain. In mice the ERT2 technology is routinely applied to induce the activity of Cre recombinase but is not yet utilised in vivo to manipulate endogenous proteins. Here, B-Raf kinase provides an excellent starting point since the functionality of mutant B-Raf-ERT2 fusion proteins to activate in vitro MAPK signalling is known. By the use of a dominant negative or hyperactive B-Raf fusion protein the fusion protein technology will be for the first time applied to the inducible enhancement or repression of an endogenous signalling pathway in brain neurons. In these mice MAPK signalling can be manipulated in a cell type specific and temporal manner by a small molecule inducer. In particular, the hypothesis that a transient increase of MAPK signalling in glutamatergic neurons of the pubertal brain, results in increased anxiety and depression-like behavior of adult mice, will be tested.

Keywords: mapk,tamoxifen,anxiety,depression,b-raf,fusion protein