Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Interrogating Human Adult Hippocampal Neurogenesis (HumAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1993792.74
EU funding (EUR): 1993792.74
Participants: 2
Project status: SIGNED

The hippocampus is crucial for learning and memory and it hosts an extraordinary form of plasticity: the generation of new neurons throughout life, a process named adult hippocampal neurogenesis (AHN). Newly generated neurons grow in a specialised niche composed of unique vascular, glial, and neuronal elements. Impaired AHN leads to cognitive dysfunction and mood dysregulation in rodents. Recent work by my group reveals the persistence of AHN until the tenth decade of human life, as well as impairment of this process in patients with Alzheimer’s disease. The general aim of HumAN is to unveil the features that confer the human hippocampus with neurogenic potential, thoroughly characterising this niche in adulthood, physiological aging, and pathological conditions (AIM 1), and to identify potentially unique AHN signatures for specific neurodegenerative and psychiatric diseases (AIM 2). Moreover, we will determine, for the first time, whether new neurons integrate efficiently into the human hippocampus (AIM 3) and we will interrogate the subcellular machinery of these cells to unravel the mechanisms underlying AHN impairments in these diseases (AIM 4). The unprecedented quality of our collection of human hippocampal samples, obtained from 180 individuals (either controls or with specific neurodegenerative or psychiatric diseases), allows successful application of trail-blazing methodologies such as RNAscope, iterative indirect immunofluorescence imaging (4i)-microscopy, and super-resolution and stimulated emission depleted (STED) nano-resolution microscopy. HumAN will break new ground in the field of AHN by deepening our understanding not only of the mechanisms that control the maturation and synaptic integration of newly generated cells in human beings, but also of the pathophysiology of neurodegenerative and psychiatric diseases, thereby facilitating the identification of potential novel therapeutic targets for these as yet incurable conditions.

Keywords: adult hippocampal neurogenesis,human hippocampus,neurodegenerative diseases,neuronal maturation
ROS-Industrial quality-assured robot software components (ROSIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Germany,Spain,Sweden,Netherlands,Denmark
Call: System abilities, development and pilot installations (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 7651236.25
EU funding (EUR): 7504236.25
Participants: 7
Project status: CLOSED

ROSIN will create a step change in the availability of high-quality intelligent robot software components for the European industry. This is achieved by building on the existing open-source “Robot Operating System” (ROS) framework and leveraging its worldwide community. ROS and its subsidiary ROS-Industrial (European side led by TU Delft and Fraunhofer) is well-known, but its European industrial potential is underestimated. The two main critiques are (1) is the quality on par with industry, and (2) is there enough European industrial interest to justify investing in it? Partially, the answer is “yes and yes”; ample industrial installations are already operational. Partially however, the two questions hold each other in deadlock, because further quality improvement requires industrial investment and vice versa. ROSIN will resolve the deadlock and put Europe in a leading position. For software quality, ROSIN introduces a breakthrough innovation in automated code quality testing led by IT University Copenhagen, complemented with a full palette of quality assurance measures including novel model-in-the-loop continuous integration testing with ABB robots. Simultaneously, more ROS-Industrial tools and components will be created by making 50% of the ROSIN budget available to collaborating European industrial users and developers for so-called Focused Technical Projects. ROSIN maximizes budget efficacy by alleviating yet another deadlock; experience shows that industry will fund ROS-Industrial developments, but only after successful delivery. ROSIN provides pre-financing for developers which will be recovered into a future revolving fund to perpetuate the mechanism. Together with broad education activities (open for any EU party) led by Fachhochshule Aachen and community-building activities led by Fraunhofer, ROSIN will let ROS-Industrial reach critical mass with further self-propelled growth resulting in a widely adopted, high-quality, open-source industrial standard.

Keywords: middleware,open source,industrial robots,quality assurance
From fluid dynamics to quantum gravity (FDtoQG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-03
End date: 2017-08-02
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Reconciling general relativity with quantum physics is the Holy Grail of theoretical physics. Today the major physical predictions involving both gravity and quantum fields, in the framework of quantum field theory in curved space-times, are black hole radiation and particle production in an expanding Universe. These phenomena are the corner stones of our present knowledge about the quantum nature of space-time, and it is of crucial importance to understand deeply their features and consequences in the quest for a quantum theory of gravity. Unfortunately, these features are still poorly understood, and are experimentally out of reach in astrophysics. This project will bring together an experienced researcher with expertise in Hawking radiation and black hole physics, with a world leader physicist in artificial space-times in fluid flows to tackle these questions in the innovative approach of analog gravity. Unlike in astrophysics, artificial black holes can be experimentally realized using fluids, showing both their classical and quantum properties. Because these fluids are well understood, both experimentally and theoretically, many conceptual questions can be explicitly addressed in such systems. By working in a world-leading group in the field at the University of Nottingham, the local expertise and mine will be the perfect match to tackle these questions.

Keywords: quantum gravity,black hole,hawking radiation,cosmology,lorentz violations
In control of exciton and charge dynamics in molecular crystals (ICONICAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The aim of the work proposed here is to achieve control over charge and excited state dynamics in organic crystalline materials and in this way to come to solid state materials with explicit built-in functionality. The charge and excited state dynamics do not only depend on the properties of individual molecules but are to a large extent determined by the interactions between multiple molecules. By careful engineering of the properties of individual molecules and of the way they aggregate in the solid crystalline state it is in principle possible to design materials that exhibit a specific functionality. Examples of this are materials that are optimized to give high charge carrier mobilities and high exciton diffusion coefficients. It is also possible to design more complex functionality. An example of this is singlet exciton fission, a process by which one singlet excited state transforms into a combination of two triplet states. This spin-allowed process can in principle increase the efficiency of organic solar cells by a factor 1.5. A second example is upconversion of low energy photons into higher energy photons. This is possible by combining two low-energy triplet excited states into a single singlet excited state by triplet-triplet annihilation. Finally, it is possible gain control over charge separation on the interface of two different materials to increase the charge separation efficiency in photovoltaic cells. In this work, we will explore ways to achieve control of charge and exciton dynamics in a combined effort including organic synthesis, computational chemistry and time-resolved spectroscopy and conductivity experiments. This research represents a major step forward in the understanding of the relation between molecular and solid state structure and the electronic properties of organic crystalline materials. This is of considerable fundamental interest but also has direct implications for the utilization of these materials in electronic devices.
HIGH SPECIFIC ENERGY ALUMINIUM-ION RECHARGEABLE DECENTRALIZED ELECTRICITY GENERATION SOURCES (ALION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Materials for a sustainable, resource-efficient and low-emission industry
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Germany,Germany,Italy,Spain,Norway,France,France,United Kingdom
Call: Storage of energy produced by decentralised sources (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 7223551.25
EU funding (EUR): 7223551.25
Participants: 13
Project status: CLOSED

The overall objective of the ALION project is to develop aluminium-ion battery technology for energy storage application in decentralised electricity generation sources. ALION pursues an integral approach comprising electroactive materials based on “rocking chair” mechanism, robust ionic liquid-based electrolytes as well as novel cell and battery concepts, finally resulting in a technology with much lower cost, improved performance, safety and reliability with respect to current energy storage solutions (e.g. Pumped hydro storage, Compressed air energy storage, Li-ion battery, Redox Flow Battery...). The project covers the whole value chain from materials and component manufacturers, battery assembler, until the technology validation in specific electric microgrid system including renewable energy source (i.e. mini wind turbine, photovoltaic system…). Thus, the final objective of this project is to obtain an Al-ion battery module validated in a relevant environment, with a specific energy of 400 W.h/kg, a voltage of 48V and a cycle life of 3000 cycles.

Keywords: energy storage
Challenging The Limits Of Molecular Quantum Interference Effects (QLIMIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1999468.0
EU funding (EUR): 1999468.0
Participants: 1
Project status: SIGNED

Over the last ten years, there has been a growing interest in quantum interference effects observed in molecules. Remarkably, given their fragility in mesoscopic physics, molecular quantum interference effects can be readily observed at room temperature in solution. This robustness comes from the extremely small size of the molecular components (1-2nm) and thereby the small dimensions over which phase coherence is required. The aim of this project is to challenge the limits of molecular quantum interference effects delivering clear predictions of how to realise these effects in three challenge areas. 1. Beyond single molecules: intermolecular interference effects. This work package will investigate interference effects between molecules and in monolayers to find systems where intermolecular interference effects emerge with a long-term view to materials. 2. Beyond classical electronics: Quantum gates Given that interference effects are an indication of phase coherence being maintained across the molecule, we should be able to exploit the quantum nature of the system for more than simply suppressing current. Proposals exist in the literature for realising a quantum computer through scattering, so this work package will investigate use the interference effects in molecules to suggest candidate systems for this type of quantum computer. 3. Beyond electron transport: Controlling vibrational energy redistribution This work package will focus on how to use interference effects to control vibrational energy redistribution within single molecules with an aim of using this to modulate product ratios in organic reactions. This project takes ideas that have come out of molecular electronics and tests the scope of their application in three neighbouring areas: supramolecular chemistry, quantum computing and organic chemistry. This project takes a first step in these directions, and success in any work package has the possibility to open a whole new field of research.

Keywords: quantum interference
Linking Climate Change, Habitability and Social Tipping Points: Scenarios for Climate Migration (HABITABLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Ethiopia,Germany,South Africa,Germany,Norway,Thailand,Switzerland,Sweden,Sweden,Belgium,France,France,Netherlands,United Kingdom,United Kingdom,Ghana,Senegal,Kenya,Mali
Call: Human dynamics of climate change (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 6779900.0
EU funding (EUR): 6779900.0
Participants: 23
Project status: SIGNED

The HABITABLE project is centred around the concept of habitability and seeks to advance our understanding of how climate change does and will affect migration and displacement patterns. It does so through the mobilisation of innovative methods to explore key research gaps, implemented by a diverse, experienced consortium associating 21 partners from different disciplines and representing a number of regions of the world, including local partners from West Africa, East Africa, South Africa and Southeast Asia. The project seeks to understand not only how climate change causes migration, but also how climate impacts, policies and perceptions interact with each other and influence migration patterns in a systems-based approach. We introduce the concept of social tipping points as a fresh way to understand how environmental disruptions can potentially trigger major social changes. The project intentionally steers away from simple linearity assumptions in an innovative research design that will focus on the entire social-ecological system, accounting for climate impacts and their perceptions, as well as adaptation options and their implementation, in order to determine the conditions for social tipping points and sustainable policy options for preventing large-scale displacement. The project mobilizes fresh methodologies and datasets in case-studies in Africa and Asia that are relevant for European policy-making. The project pursues a non-deterministic understanding of the impact of climate change on migration, and enables a systematic comprehension and appreciation of the complex social, economic and environmental interactions involved. This allows us to develop policy-relevant migration scenarios. On this basis, the project will propose a number of adaptation options for populations affected by climate change, as well as recommendations to inform key policies, in particular the European Agenda on Migration.

Keywords: climate impacts,migration,displacement,mobility,asylum,modeling,habitability,social tipping points,scenarios
Biocontrol of Xylella and its vector in olive trees for integrated pest management (BIOVEXO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Spain,Austria,Italy,Spain,Spain,Belgium,Belgium,Slovenia
Call: Demonstrate bio-based pesticides and/or biostimulant agents for sustainable increase in agricultural productivity (H2020-BBI-JTI-2019, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 8025112.41
EU funding (EUR): 6612227.48
Participants: 12
Project status: SIGNED

BIOVEXO demonstrates a set of new and innovative biopesticides targeting the plant-pathogenic Xylella bacterium and its transmitting spittlebug vector, to fight a disease that seriously threatens olive and almond production in the European Mediterranean region. BIOVEXO’s biopesticides will reduce the input of chemical insecticides and will sustainably increase and secure European olive cultivation in its valuable socio-economic context. The biopesticides will be tested for use in curative and preventive approaches. We introduce six promising candidate biocontrol solutions acting either against Xylella or its vector, which include two bacterial strains, a microbial metabolite, two plant extracts, and an entomopathogenic fungus. Following small-scale on-field validation and improved formulation, BIOVEXO will upscale production of best-performing biopesticides (minimum two Xylella- and two vector-targeting ones) to large pilot scale for real-life evaluation in two major Xylella outbreak regions in Europe (Apulia, Italy and Mallorca, Spain) representing distinct pedoclimatic conditions. Then, BIOVEXO’s biopesticides will be demonstrated in a combined and integrated approach (IPM) on traditional and newly planted olive orchards in the two areas. Additional testing is done on almond trees in mainland Spain and Mallorca. The BIOVEXO consortium coming from academia, large industry, SMEs and associations contributes complementary expertise all along the value chain including practical knowledge and hands-on experience by participating olive growers and farmer associations. BIOVEXO will provide a mechanistic understanding of the biopesticides’ mode of action to support final product development and will ensure environmental and economic sustainability by performing LCA and risk, toxicity, and pathogenicity analyses. Thorough evaluation regarding regulatory compliance will prepare BIOVEXO’s biopesticides for smooth market entry post project.

Keywords: olive,xylella,vector,biopesticides,biocontrol,bacterial pathogen,mode of action,field trials,sustainable
Neural regulation of immunity (NEURIMMUNE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. Pain is one of the major signs of inflammation. Upon acute injury, inflammation or infections noxious signals are perceived by nociceptors present in tissues, such as the skin. These sensory neurons convey the damaging information to the brain and release a number of mediators locally that could modulate immunity. The goal of this project is to decipher the functional role of sensory neurons and pain sensitivity on immune responses. We will tackle this highly challenging question by studying the immune responses to vaccination in genetic mouse models in which skin innervation by nociceptors is deficient. Our preliminary results are very promising as we already demonstrated that deficits in sensory skin innervation affect both the innate and adaptive immune responses to intradermal vaccine. We will further study the cellular and molecular mechanisms involved in this local and systemic modulation of the immune response by the nervous system. As a complementary approach, we will address the role of an exacerbated pain response on immunity through the selective stimulation of nociceptive neurons in wild type animals. This interdisciplinary study is designed to provide new insights into how the nervous system instructs the immune system. Results from NEURIMMUNE are expected to open new avenues of research on the integrated host response to pathogens with important implications for the design of innovative prophylactic vaccines and therapies.

Keywords: skin,nociceptors,vaccine