Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Periodontal Regeneration through Femtosecond laser Action (PRe-FActo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The PRE-Facto fellowship aims to develop a new regenerative approach which potentially will promote the revival of the periodontium, while a successful outcome may lead also to the prevention of the disease when intervened early. Within my research I am going to develop a new biomaterial (calcium phosphates doped with ions of say, cerium and erbium oxides, fluoride and aluminum (3+) ions) with antibacterial properties which will be densified and bonded on the tooth surface after the irradiation with an ultrafast pulsed laser (femtosecond laser). In order to promote the attachment of the fibroblasts, the biomaterial will be mixed with collagen gel (or chitosan) while the effect of the surface topology will be also tested. For my research training as a bioengineer within which I aim to solve periodontitis as a global problem I will deal with the following Research Training Activities (RTAs); i) Synthesis, characterization and delivery of the biomaterial; ii) Sintering of the materials with femtosecond laser - characterization of the sintered area; iii) Cell culture and histological studies for exploring the regenerative potential of the material; iv) Toxicology tests and potential risks investigation. This training is not only beneficial for the fellow’s scientific career development, but also for the host institute (the University of Leeds) and the general public health. The above listed training activities will be supplemented by a number of non-Technical skills for my career development. As a result of this cross-disciplinary project the fellow will be a well-rounded bioengineer researcher who in future will be become qualified for pursuing an academic career at the University of Leeds in the area of advanced drug delivery and photo-dynamic therapy using novel femtosecond lasers. Necessary research training and supervision at the UoL will be provided by the Engineering supervisor Prof. Animesh Jha (AJ) and the clinical supervisor Prof . Monty Duggal.

Keywords: periodontitis,hard soft tissue reattachment,femtosecond lasers,oral health,biomaterials
The overall objective of the Project is to increase the innovation management capacity of the innovative Armenian SMEs with potential of growth by provision of innovation support services. (H2020 Armenia)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Armenia
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 12642.5
EU funding (EUR): 12642.5
Participants: 2
Project status: CLOSED

The overall objective of the EEN Armenia H2020 Project is to increase the innovation management capacity of the innovative SMEs with potential of growth and internationalization by provision of innovation support services established within EEN Armenia.

Keywords: h2020,innovation,sme instrument,armenia,sme development
Identifying the steps required for meiotic DNA double-strand break formation (DSBSunrise)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-12-01
End date: 2026-11-30
Duration (months): 72.0
Total project cost (EUR): 2170000.0
EU funding (EUR): 2170000.0
Participants: 1
Project status: SIGNED

At the onset of prophase of the first meiotic division, meiotic cells undergo complex molecular events with the induction of several hundred DNA double-strand breaks. These DNA breaks are required because they initiate recombination between homologous chromosomes and to allow chromosome segregation during meiosis. They are essential for fertility. However, they represent a major challenge for genome integrity. It is thought that meiotic DNA break formation is under tight control to ensure that all breaks are properly repaired to maintain genome integrity. But how this control implemented is unknown. We postulate that three critical steps take place to ensure meiotic DNA break formation at the right time, right place, and right frequency. We will test this hypothesis by addressing in mice the three following questions: Q1: We will ask whether a homology-sensing process brings homologous chromosomes in spatial proximity before DNA break formation to improve DSB repair efficiency and avoid topological conflicts. If this is the case, we will determine the molecular mechanism. Q2: We will determine whether the genomic sites undergoing DNA breakage interact with structural components of chromosome axes before break formation, and how. This interaction is predicted to be necessary for proper DSB repair. Q3: We will determine how DNA cleavage is activated. We will do this through in vitro reconstitution of meiotic DSB formation. Answering these key questions will be possible by using in vivo and in vitro approaches. We will pioneer in vitro meiotic differentiation of mouse embryonic stem cells to overcome the current limitations for identifying novel components and interactions. We will thus decipher how a molecular machinery that has evolved from a DNA type II topoisomerase family has been selected and modified to promote a complex reaction initiated by DNA cleavage at multiple sites along chromosomes followed by their repair by homologous recombination.

Keywords: meiosis,topoisomerase,genome stability,dna breaks,cohesins
A software engine for multi-criteria decision support in flight management (Pilot3)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Germany,Spain,United Kingdom
Call: Software engine for multi-criteria decision support in civil aircraft flight management (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-11-01
End date: 2022-01-31
Duration (months): 27.0
Total project cost (EUR): 660062.5
EU funding (EUR): 629912.5
Participants: 4
Project status: CLOSED

Pilot3 will develop a software engine model for supporting crew decisions for civil aircraft. This software will provide a set of options to the pilot with information to help the crew select the most suitable one considering multi-criteria business objectives of the airline. Pilot3 will look integrate airlines flight policies and overall performance targets to select and rank the alternatives. The system does not only consider the flight but the whole network operations of the airline. Pilot3 is composed on four different subsystems: Indicators Estimator, Alternatives Generator, Performance Assessment Module and HMI. The first three will be developed during the project, while a HMI will be designed. Pilot3 will specify the software interface so that it can be integrated in larger systems. The Indicators Estimator will provide an estimation of the different performance indicators for a given trajectory. Pilot3 will allow the airline to select how to estimate these values: using airborne information, ground information, with analysis of data and heuristics or with machine learning predictors. The Alternatives Generator will automatically compute different alternative trajectories considering the airlines' flight policies and its performance goals. This system will also allow the pilot to add constraints and even to specify a given trajectory to be assessed. This module will perform a multi-objective optimisation. The Performance Assessment Module will compare the expected performance of each alternative trajectory produced by the Alternatives Generator and rank them according to the overall airlines' goals. Finally, the designed HMI will present the information to the pilot and allow the crew to interact with the system, accepting an alternative, rejecting them (triggering a re-computation of alternatives) or adding constraints. Pilot3 will contribute to the capture and definition of flight policies and allow airlines to define enriched policies.

Keywords: multi criteria decision making,trajectory optimisation,performance indicators,machine learning,decision support tool,airline operations,disruption management
De nova of transcription regulators from taxol®-producing endophytic fungi (Taxol biosynthesis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Summary We propose to biosynthesis de novo of fungal taxol® production by the regulation of transcription factors (TFs). However, such a scenario is not yet to be investigated in case of taxol-producing endophytic fungi. The principle aim of this project is to isolate TFs genes WRKY, AP2, MYP etc. that specifically regulate the expression of taxol biosynthetic rate limiting gene promoters using transient RNAi. The attractive features of this study, examining the elicitor-induced regulator of selected TFs genes to see whether their mRNA levels correlate with fungal taxol biosynthesis. In order to identify key regulators of taxol pathway, cDNAs will be explore to obtain the recombinant TF protein. This project offer de nova interactions between the TFs and the TB gene promoters, which results of DNA binding cis-elements. It can be exploited to produce superior increased taxol yields from wild or transgenic fungi. This programme of work will provide a new strategy for unlocking the full potential of fungal biotechnology at the interface with metabolic engineering and rDNA technology to establish of fungal fermentation through genetic engineering approaches. The complementary expertise of Dr Kamal (Fungal biotechnology) and the supervisor Prof. Dr. Frank Kempken (FK) (Fungal genetic and molecular biology) offer the unique combination to realize the fungal taxol biosynthetic potential. Overall, this research will lead to a comprehensive understanding of the key TFs that control elicitor induced metabolic changes to produce highest yield of fungal taxol and will provide intellectual property (IP), technology development, which lead to Dr. Kamal with new and cutting-edge research training.

Keywords: taxol biosynthesis,transcription factors,elicitor,endophytic fungi
Promoting Youth Scientific Career Awareness and it Attractiveness through Multi-stakeholder Co-operation (MultiCO)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Cyprus,Finland,United Kingdom
Call: Innovative ways to make science education and scientific careers attractive to young people (H2020-SEAC-2014-1, 2014)
Start date: 2015-08-01
End date: 2018-11-30
Duration (months): 40.0
Total project cost (EUR): 1393750.0
EU funding (EUR): 1393750.0
Participants: 5
Project status: CLOSED

This project builds on literature research outcomes and proposes to study the impact of real life related, career-focused stories (referred to as scenarios) as the introduction to the learning of science subjects by secondary school students (ages 13 to 15). Through such an innovative development, initiating motivational and meaningful context- and inquiry-based science studies, the project researches the impact on learning and attitudinal gains, as well as students’ own ideas to enhance the relevance of science studies. The target is to increase students’ future preferences for choosing science studies and their desire to reflect on and pursue science-related careers. There has been a general educational trend towards context-based approaches and viewing science education as being education through the context of science. Context-based approaches and strategies that actively engage students in the learning process have been shown to result in improvement in students’ attitudes towards science, although the need for students to input their ideas and their indigenous knowledge should be taken into account. However, research has shown that middle grade students were not aware of career options, were not conversant with competences needed and few indicated knowing professionals actively working in the science, technology, engineering and mathematics fields. Yet in recruiting graduates, employers have indicated that a range of skills were important and that the most important skills were team working, sector-specific and communication skills. The intended project outcome is to raise youth awareness of the role of science and technology in society, an awareness of science and technology careers and orientation of students towards gaining positive views towards undertaking science careers. The project is planned as a longitudinal study over 3 years, involving multi-stakeholder co-operation between different stakeholders.

Keywords: youth participation
Demonstration of the economic feasibility of a wave-powered desalination system (W2O)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Ireland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Over 1 billion people suffer from the effects of water scarcity with the vast majority being poor residents of developing countries. Desalting seawater is an excellent potential solution but traditional reverse osmosis (R/O) desalination systems require a connection to a strong electrical grid. However, because developing countries typically lack sufficient electrical grid capacity and cannot afford the capital or time required to build and deploy traditional R/O systems, RML is proposing an innovative solution to this problem - the world’s first wave-driven desalination system (called Wave2O™) that can be deployed quickly, operate completely “off-grid” and supply large quantities of fresh water at competitive cost. As a medium-scale, grid-independent, renewable energy driven water production system, we believe Wave2O™ will have wide-ranging utility in developing countries and island nations outside Europe. Inside Europe, potential markets include the overseas Departments and Territories linked to EU member states (e.g. Canary Islands, New Caledonia, etc.). RML has already been active in several countries and has obtained commitments for pilot-scale Wave2O™ plants in Cape Verde, South Africa and Mauritius. We believe Cape Verde represents the shortest path to commercialization. The pilot location has been already secured and the site assessment studies are expected to start in Q3 2017 financed by the African Development Bank through a $1.0M SEFA (Sustainable Energy Fund for Africa) grant. The purpose of the W2O project will be to build upon the SEFA-funded site assessment studies to determine the economic feasibility of Wave2O™ in Cape Verde and to pave the way for the commercial pilot in 2019. The eventual global deployment of Wave2O™ plants will help create a very competitive European export industry.

Keywords: wave,water,desalination
Building a Robotics and Artificial Intelligence Network (BRAIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-04-01
End date: 2020-12-31
Duration (months): 21.0
Total project cost (EUR): 2448851.25
EU funding (EUR): 1714195.88
Participants: 1
Project status: CLOSED

The Kobi Company (“Kobi”) is a young, award winning robotics company based in Leuven, Belgium. The problem which Kobi solves and which is driving this demand, is the fact that in many labour-intensive industries, the number one problem for companies is finding skilled personnel whilst maintaining a competitive price. Manufacturers (OEMs) active in these industries know the market is demanding robotic solutions, but many do not have the expertise to tackle this robotization wave by themselves. That is why OEMs turn to Kobi and its patented and highly scalable robotics platform (the “Brain”) that can easily be integrated into existing OEM equipment and turn them into autonomous machines. The Brain far outperforms any existing alternative on the market today from a price/performance perspective. Furthermore, the robotics platform is reinforced with an Artificial Intelligence layer to improve contextual and environmental awareness. The product-market fit and economic feasibility has been confirmed by signed contracts Kobi has closed with several large OEMs. Kobi has chosen for a business approach whereby existing OEMs are no longer regarded as direct competitors but as strategic partners. Establishing mutually beneficial strategic partnerships with OEMs will allow Kobi to capitalize on their strong (distribution) networks and sales channels, thereby achieving hyper-scalability. This SME project aims to fine-tune the Brain, finalise the go-to-market strategy, level the playing field with respect to the large OEMs, and the exploitation plan for immediate implementation to accelerate commercial scale-up so that the company can rapidly grow internationally. Revenue forecasts are expected to increase from ~€ 1 million in 2019 to ~ € 12 million by 2021 and €99 million by 2023. To support the surge in sales, Kobi demands a rapid employment increase, from 7 FTEs to 125 FTEs by 2023.
Glycans coated nanoparticles as a biocompatible shield to increase nanoparticles colloidal stability and modulate their immunological response. (Glyco-NPs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

Nanomedicine is currently the most studied and promising topics in the field of biomedical technology, which is focused on developing nanoparticles. The reason for this is that these materials present unique properties such as size, high ratio area/ volume, chemical reactivity, that offer potential solutions for many of the current challenges in diagnosis, therapy and vaccines on several diseases. However, the safe use of NPs in clinical applications is not established yet. At present, the NPs have limited stability in complex cell media, enhanced recognition by the immunological system and reduced targeting efficacy as a result of the protein corona formation. Studies in Dr. Monopoli´s laboratory at RSCI have demonstrated that glycosylation of the protein corona plays an important role in maintaining the colloidal stability of nanoparticles and influences nanoparticle-cell interactions. The proposed research programme will utilize the combination of interdisciplinary and intersectoral approaches (synthetic chemistry, physical chemistry, glycoprofiling and proteomics, an inter-sectoral secondment (CIC biomaGUNE, Prof Sergio Moya to learn fluorescence correlation spectroscopy and test the NP targeting efficacy) to synthetise a range of nanoparticles (NPs) decorated with synthetic and naturally occurring glycans (hence, Glyco-NPs) in order to: 1), increase the NPs' colloidal stability, 2) attenuate the unspecific protein interaction and 3) increase the NPs circulation half-life into the bloodstream. Together with my supervisor, we have designed a training plan that includes new research (glycoprofiling and bio-nanointeractions), and transferable (project management, leadership, innovation) skills.

Keywords: nanoparticles,protein corona,glycans,colloidal stability,immune response,cellular uptake,biodistribution