Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accelerating the Dissemination of Agluna(R), a clinically proven innovative silver ion based anti-microbial surface technology, from orthopaedics sector into the dental implant sector (ADA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project objective is to confirm the commercial application of Agluna(R), an innovative silver ion based anti-microbial surface technology, to dental implants. Agluna(R) has already demonstrated a significant reduction in the incidence of post-operative infection in clinical use within the EU limb salvage market, and is being actively commercialised within the wider global orthopaedic market. Implant related infections are associated with the formation of biofilm on the surface of implanted devices. This is a global problem with socio-economic costs recognised across a range of medical device sectors. The dental implant sector is actively searching for solutions to the problem of post-operative implant infection (peri-implantitis). With growing concern about antibiotic-resistant bacterial strains, the subsequent expected outcome following this project is for Agluna(R) to become commercialised in EU/global markets as a differentiated, cost effective and clinically proven technology utilising silver ions, a well-known biocide with very limited reported bacterial resistance. Phase 1 will confirm a business plan for successful commercialisation of Agluna(R) in the dental implant sector. We seek confirmation of: - the size and scope of the EU and global market opportunity in the dental sector; - competing approaches to prevention and control of post-operative infection in this sector; - market entry strategy taking account of EU and other international regulatory pathways; - investment requirements, time to market, and return on investment. Phase 1 is six months in duration; the principal deliverable is a fully substantiated business plan. This will provide the basis for Phase 2, in which Agluna(R) will be piloted on a dental implant product that is designed, manufactured and clinically tested in a human proof of concept study.

Keywords: anti microbial,silver ions,infection dental implants,advanced manufacturing process
Formation of nano-scale clusters from atmospheric vapors (nanoCAVa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland,Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 265082.4
EU funding (EUR): 265082.4
Participants: 2
Project status: CLOSED

This research concentrates on advancing the understanding of the border between the gas and condensed phase by studying the formation of nanoscale clusters from atmospheric vapours (NanoCAVa). Cluster formation and growth is a crucial step in forming new aerosol particles in the atmosphere. We aim to resolve the role of molecular clusters in aerosol formation by targeted field measurements at various locations and precisely controlled chamber experiments. Using and further developing the latest measurement technology, and combining physical and chemical information, enables us to get a full characterization of neutral clusters, which is so far lacking. We utilize the results to create a better description of the dynamics of 1 – 5 nm nano-particles, which often cannot be treated with traditional theories, and to implement the concept of a cluster mode into the general view on the atmospheric aerosol size distribution. Understanding the factors controlling the growth of newly formed clusters into climatically relevant particles and cloud condensation nuclei (CCN) enables estimating their importance in the climate system more accurately. This project will facilitate the ER to pursue a successful research career in atmospheric science and establish her position as an expert of nano-particle measurement technology. It will also strengthen the role of the beneficiary and the partner organization as the leading groups in atmospheric nucleation research and their mutual collaboration.

Keywords: aerosol formation,molecular clusters
Central integration of metabolic and hedonic cues in metabolic health (INTEGRATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2499714.0
EU funding (EUR): 2499714.0
Participants: 1
Project status: CLOSED

During evolution the brain has selected glucose as a main source of metabolic energy. This has imposed homeostatic and behavioral constraints. First, the glycemic levels must be maintained at a minimum of ~5 mM to ensure constant energy supply to the brain. Second, a high reward value has to be attributed to glucose-containing foods to increase the motivation to obtain them. These homeostatic and hedonic regulations depend on glucose sensing cells and neuronal circuits in the central nervous system. These cells and circuits regulate the activity of the sympathetic and parasympathetic nerves, which control the function of peripheral organs (liver, fat, muscles) and the secretion of glucagon and insulin by pancreatic islet cells. They also attribute a reward value to glucose-containing foods to control food-seeking behavior, a process that involves the mesolimbic dopaminergic system. Here, we will focus on three interrelated aims: 1. Identify the physiological role of glucose sensing neurons of the ventromedial hypothalamic nucleus (VMN, a key feeding and glucoregulatory center) in glucose homeostasis and food preference; identify their cellular diversity and their molecular make-up; and characterize their deregulations in metabolic diseases. 2. Characterize the molecular physiology of glucose sensing neurons of the paraventricular thalamus, which modulate the activity of the mesolimbic dopaminergic system to control motivated sucrose-seeking behavior; determine their control by other interoceptive signals, including from glucose sensing cells of the VMN. 3. Establish new molecular approaches to characterize, at the molecular and functional levels, the impact of early postnatal nutrition on the development and function of central glucose sensing cells in the control of adult animal physiology. These studies will open-up new perspectives in the understanding of homeostatic and hedonic regulatory pathways, which preserve metabolic health over a lifetime.
EU Intersex Citizenship (EUICIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-09-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The EUICIT action addresses the rights claims and agendas of intersex people and those with Disorders of Sexual Development (DSD), in response to recent Council of Europe recommendations to revise medical and policy approaches. The term 'Intersex' refers to people born with sex characteristics (chromosomal, gonadal and/or anatomical) not easily classifiable as either male or female; at least 1 person in 2000 is intersex/has DSD. Intersex/DSD people are a highly marginalised section of the EU population. Conflicts exist between those who seek to depathologise intersex and those who seek rights within the medical framework (DSD-oriented. There is a pressing need for research that highlights the experiences, understandings, and views of intersex/DSD people within a European context. In particular, an investigation of debates about intersex versus DSD perspectives is necessary, because of the divergent human rights and social policy implications of these two approaches. EUICIT is framed within interdisciplinary citizenship and participative democratic approaches, in order to highlight human rights issues, and to explore tensions between medical-oriented rights claims and those that seek depathologisation. It uses triangulated qualitative research methods: documentary and policy analysis across the EU, interviews with activists and healthcare/policy actors in Italy, the UK and Switzerland, and participant observation in a secondment organisation (Zwischengeschlecht- ZW). The case study countries were chosen to represent varied types of intersex/DSD activism and relationship to the EU. ZW, which is based in Switzerland, takes a combined medical/activist approach; it is actively engaged in policy work at national and international levels and is ideally suited to fieldwork on the topic. The project team has been assembled to help the applicant develop her existing expertise, drawing in expertise of gender theory, citizenship and human rights.

Keywords: intersex,policy,medical approach,depathologisation,qualitative research methods,activists,gender theory,citizenship,human rights
Oasis Innovation Hub for Catastrophe and Climate Extremes Risk Assessment (H2020_Insurance)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Austria,Spain,Hong Kong,Hungary,Serbia,Hungary,France,France,France,Netherlands,Kenya,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Brazil
Call: Exploiting the added value of climate services (H2020-SC5-2016-TwoStage, 2016)
Start date: 2017-05-01
End date: 2020-10-31
Duration (months): 42.0
Total project cost (EUR): 5447922.01
EU funding (EUR): 4802522.01
Participants: 23
Project status: CLOSED

Globally, there is increased concern of the potential impacts of extreme climate events and their impact on loss and damage of people, assets and property as a result of these events. Therefore, natural partners in using climate services to assess risk are the Global Insurance Sector, who are key implementers in increasing societies resilience and recovery of extreme events and who are integral, co-design partners in this programme. This project intends to operationalize a system, called the Oasis Loss Modelling Framework, that combines climate services with damage and loss information and provides a standardised risk assessment process that can assess potential losses, areas at most risk and quantify financial losses of modelled scenarios. We intend to prove the Oasis LMF system through undertaking a range of demonstrators linked and co-designed to ‘real’ situations and end-user communities in the insurance, municipalities and business sectors (see list of partners & collaborators). These demonstrators have already been agreed with our end-users and develop work around hydro-climatic risk (in the Danube Region), Typhoon Risk, African Farmer Risk – through using climate information to support the underwriting of micro-insurance, climate v health and climate v forest asset risk assessment. We also intend to further expand access by all sectors to the models, tools and services developed within this programme and the broader climate services sector by operationalizing an open eMarket place and matchmaking facility for catastrophe and climate data and models, tools and services and through broadening awareness in the climate modelling and end-users communities to the Framework, and the transparent and comparable standard it offers to support evidence based risk assessment and adaptation planning.

Keywords: climate services,insurance,reinsurance,microinsurance,risk analyses,loss modelling framework,oasis,climate informed decision making,climate services demonstrator
Accelerating the lab to market transition of AI tools for cancer management (CHAIMELEON)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Israel,Germany,Italy,Austria,Spain,Spain,France,France,Netherlands,United Kingdom,Portugal
Call: AI for Health Imaging (H2020-SC1-FA-DTS-2019-1, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 8784038.75
EU funding (EUR): 8784038.75
Participants: 20
Project status: SIGNED

CHAIMELEON aims to set up a structured repository for health imaging data to be openly reused in AI experimentation for cancer management. An EU-wide repository will be built as a distributed infrastructure in full compliance with legal and ethics regulations in the involved countries. It will build on partner´s experience (e.g. PRIMAGE repository for paediatric cancer and the Euro-BioImaging node for Valencia population, by HULAFE; the Radiomics Imaging Archive by Maastricht University; the national repository DRIM AI France, the Oncology imaging biobank by Pisa University). Clinical partners and external collaborators will populate the Repository with multimodality (MR, CT, PET/CT) imaging and related clinical data for historic and newly diagnosed lung, prostate and colorectal cancer patients. A multimodal analytical data engine will facilitate to interpret, extract and exploit the right information stored at the Repository. An ambitious development and implementation of AI-powered pipelines will enable advancement towards automating data deidentification, curation, annotation, integrity securing and images harmonisation, the latest being of the highest importance for enabling reproducibility of Radiomics when using large multiscanner/multicentre image datasets. The usability and performance of the Repository as a tool fostering AI experimentation will be validated, including a validation subphase by other world-class European AI developers, articulated via the organisation of Open Challenges to the AI Community. A set of selected AI tools will undergo early on-silico validation in observational (non-interventional) clinical studies coordinated by leading experts in Gustave Roussy (lung cancer), San Donato (breast), Sapienza (colorectal) and La Fe (prostate) hospitals. Their performance will be assessed, including external independent validation, on hallmark clinical decisions in response to some of the currently most important clinical end points in cancer.

Keywords: repository,regulatory compliance,cancer management,lung cancer,breast cancer,colorectal cancer,prostate cancer,magnetic resonance,computed tomography,imaging biomarkers,radiomics,ai tools
Cold-Water Coral Community Dynamics (CWCC-Dynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-07-29
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Mounds and margins on the North Atlantic host highly diverse and structurally complex megabenthic communities, such as cold-water coral (CWC) reefs. These communities have been widely impacted by fishing activities, and thus CWC reefs are identified as vulnerable marine ecosystems in need of protection. Recently, several deep-sea environments (e.g. mounts, canyons) hosting CWC reefs, in EU Atlantic waters have been integrated in Marine Protected Areas (MPA). However, few of these MPAs have incorporated management plans. To establish suitable management policies, it is required to implement monitoring strategies that account for these diverse community dynamics and how they may be influenced by environmental drivers. Particulate organic carbon (POC) fluxes are known to shape deep-sea benthic communities, indicating that variations in food supply is a major driver affecting community structure and dynamics. Yet, the relationship between POC fluxes and benthic community dynamics at different temporal and spatial scales are not fully understood. Elucidating deep-sea benthic community dynamics, represents an important challenge for future research especially as management of human impacts becomes a priority. This project’s main goals are to assess the dynamics of CWC communities in mound and margins on the North Atlantic, and examine how different environmental factors may be influencing them. Community dynamics will be assessed via convolutional neural networks which will allow to assess changes in community composition and structural complexity on 3 areas that have been monitored with benthic platforms equipped with HD cameras and several environmental sensors during several months (12 – 24 months). This project will be of wide scientific interest as it will provide insight into the resilience of CWC communities to environmental change and the basis to establish a set of essential variables to be monitored over the long term and support sound conservation actions.

Keywords: benthic community dynamics,deep sea ecosystems,megabenthos,cold water corals,ecological monitoring,deep learning,primary production
Illuminating the role of transcription factor dynamics in development (TF-Dynamics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1330400.0
EU funding (EUR): 1330400.0
Participants: 1
Project status: SIGNED

Understanding how genomic regulatory elements encode when and where genes are expressed in development remains one of the most important open questions in biology. Despite intense study, this knowledge gap persists because technological limitations have obscured an important degree of freedom: time. Recent discoveries made with live cell imaging have defied the textbook view of how transcription is regulated. Hence, the time is ripe to introduce a new paradigm for studying transcription in development—one based on how genes are regulated in living animals as development is actually taking place. Excitingly, we can now exploit the cutting-edge live imaging technology and quantitative approaches that I previously developed in order to visualize transcription factor (TF) concentration dynamics, transcription, and even single TF molecules in live Drosophila embryos to uncover how enhancer sequence regulates transcription in vivo. This ambitious work will span multiple length scales, from examining changes in TF concentration at the single-nucleus level, to measuring the formation of local clusters of TFs at the locus level, to watching individual protein-protein interactions as they drive transcription at the molecular level. First, we will understand how TF concentration dynamics regulate gene expression. Second, we will uncover how recently discovered dynamic TF clusters or condensates regulate transcription and how their properties are shaped by enhancer sequence. Finally, we will overcome one of the most daunting technical challenges facing the field of transcription by developing a method to directly visualize the transient protein-protein interactions that drive transcription in vivo. Simultaneously visualizing protein-protein interactions and tracking transcription will make it possible to address the most pressing questions about transcription mechanisms in vivo, by revealing precisely when they occur and how they modulate transcription.
Cerebellar Rhythmic Entrainment with Transcranial Magnetic Stimulation: A new approach for the study of cerebellar connections with the cortex. (cRETMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Adaptation to rapidly changing environmental demands is oneThe adaptation to rapid environmental changes represents one of the most important features of the nervous system. This process is regulated by the influence of the cerebellar output over the motor cortex (M1). Information exchange between the cerebellum and M1 is achieved through rich anatomical connections, and is essential for efficient motor adaptation. However, a macro-scale understanding of the dynamics of this connectom is still poorly understood. The originality of this project is to combine, for the first time, cerebellar rhythmic transcranial magnetic stimulation (rTMS), online electroencephalography (EEG) recordings, and offline diffusion magnetic resonance imaging (dMRI), for the study of cerebello-to-M1 connections. Specifically, cRETMS is articulated in two work-packages (WPs). WP1 will pave the technical ground by probing the hypothesis that cerebellar β-oscillations are physiologically relevant in terms of cerebello-to-M1 anatomical and effective connectivity. WP2 will use the technical proofs of concept coming from WP1 to test the importance of cerebellar β-frequency in the adaptation of motor movements, with the aim of enhancing human motor performance by means of rTMS. The present action may lead to a breakthrough into our mechanistic understanding of cerebellar-to-M1 functional connectivity, which in turn may inform interventions for the manipulation of brain oscillations subtending normal and impaired motor functions. The training provided by my supervisors will be essential to reach these goals. Through them and the excellency of the host institution, this fellowship will give me the opportunity to learn how to analyse diffusion magnetic resonance imaging (dMRI) data, and how to integrate structural and dynamic information coming from the brain. This will undoubtedly increase my chances to further advance my career, deepening my scientific expertise to become an independent researcher.

Keywords: rhythmic tms,dmri,cerebellum,motor adaptation,connectivity,oscillations