Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Maternal Obesity and Epigenetic Reprogramming: from Gametogenesis to Early Embryonic Development (MOBER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-12-01
End date: 2019-11-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Obesity is a worldwide epidemic with major health consequences. One devastating consequence of obesity is ovarian failure and infertility in women. Obesity causes endocrine dysfunction that compromises particularly the female gamete, the oocyte. Importantly, maternal obesity also affects the offspring, predisposing children to obesity and type 2 diabetes. In the present proposal we will build on the unique expertise of the host lab and research experience of the postdoctoral fellow to address how maternal obesity promotes epigenetic changes in the oocyte and affects early embryonic development. The proposal will exploit the synergies between two laboratories in a multidisciplinary research setting. The candidate has a background in reproductive medicine and endocrinology, with 5 years of postdoctoral experience over which the candidate has been producing a relevant body of preliminary data on obesity and ovarian failure. The partner laboratory in Poland will contribute know-how and animal models for the study of obesity, as well as support from the local team. The host laboratory will provide methods and access to state-of-the-art facilities for epigenetic analysis. Our results, will enable us to clearly understand: (i) the extent to which the oocyte is vulnerable to maternal obesity; (ii) if epigenetic changes established in the oocyte interfere with early embryonic development. We will analyse the oocyte and early embryo epigenome and transcriptome of mouse strains with different susceptibilities to obesity and diet-induced obesity protocols representative of our social dietary habits. We will critically assess the potential health consequences of maternal obesity for the offspring. Ultimately, the knowledge generated through this proposal will lead to the public sector being better informed and new political and pharmacological strategies can be conceived for the improvement of female fertility and prevention of disease in offspring.

Keywords: epigenetics,methylome,transcriptome,obesity,metabolic syndrome,diet gene interactions,gametogenesis,oocyte,fetal programming,early embryo
Not one but many: adopting structural flexibility in the analysis of the evolution of lncRNAs. (MULTI_FOLDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-05-26
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 2
Project status: CLOSED

Long non-coding RNAs (lncRNAs) are abundant in mammalian transcriptomes. However, it remains unclear how many of them are functional, and how their functions are performed. LncRNAs seem to be poorly conserved at the sequence level, but some of them share conserved structural elements and are present at syntenic genomic positions in different species. A recent study revealed that secondary structure constrains sequence variation in lncRNAs, so that polymorphisms are depleted in low accessibility regions and tend to be neutral with respect to structural stability. This is in contrast with previous analyses that dismissed relationships between structure and sequence evolution in lncRNAs. A crucial difference in the former study is that the considered structural feature, accessibility, is computed from an ensemble of thermodynamically stable structures. Moreover, high-throughput structure probing shows that many lncRNA sites exhibit positive signals for both single- and double-strand specific enzymes, suggesting several structures may coexist. Based on this, I argue that the difficulty of identifying links between sequence and structure in lncRNAs results in part from limitations imposed by assuming a single, stable structure. I thus propose to consider ensembles of co-existing structures in lncRNAs, and develop a new computational framework that enables this. Using this new paradigm, I will study lncRNAs from animals and fungi by coupling experimental data from RNA structure probing to novel computational approaches that overcome current limitations. Overall, this novel multidisciplinary approach will profoundly impact our understanding of the evolution of lncRNAs. Furthermore, my project should help to fill the gap between structure and function of lncRNAs in different species. Moreover, as many lncRNAs are involved in a variety of human diseases, these results may provide insights towards novel clinical applications.

Keywords: long non coding rnas,evolution,secondary structure,fungi
hey!Education: Breaking Classroom Communication Barriers (HeyEducation)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Researchers, educators and learners themselves acknowledge that ICT properly integrated into the learning process enables and fosters academic success. However, the proper implementation of ICT for educational purposes is not an easy task, and requires that barriers such as monitoring learner’s devices, assessing the use of ICT, lack of educator’s digital competences and budget restriction be overcome. Hey!Education is an innovative solution to these challenges. Our educational platform is a real time two-way communication channel between the learners and the educator that enables the latter to seamlessly monitor the learner’s devices at a glance. In addition, it is a complete educational suite by which the educator can organize and impart his or her lesson with the help of polls, quizzes and games. It can also be used to stay in contact with parents, send homework and work in collaborative projects, all through our platform. Nevertheless, Hey!Education is lightweight on school resources such as bandwith and easy to use by unconfident educators with reduced digital competences. All the data generated with the use of our platform, such as assessments results, device use statistics, etc., can be accessed by the educators, learning institutions or decision makers to assess current strategies and develop future ones. The global Smart Education and Learning market is expected to witness a tremendous growth, reaching €474 billion by 2021. Our internationalization strategy starts from Spain, where Crambo is based, and spreads over Europe and Latin America where we have a network of potential clients as well as distributors interested in our platform. We have estimated our Maximum Addressable Market to be almost €9 billion during the first 4 years of business, out of which we aim at capturing over €44 million by our fourth year of commercialization.

Keywords: ed tech,educational software,bring your own device,formative assessment
ADDitive mAnufacturing oPTimized TAilored SEALS (ADDAPTTA SEALS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Seals for FTB#2 Wing with Additive Manufacturing Technologies (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2021-02-28
Duration (months): 29.0
Total project cost (EUR): 546653.75
EU funding (EUR): 407768.38
Participants: 3
Project status: CLOSED

Primary mission of the wing and the different aerodynamic surfaces is creating lift as optimum as possible. Elastic seals are needed to avoid the air to flow by the gaps between the different surfaces that could cause a malfunction of the aerodynamic component or even the complete wing. Commonly the currently used seals are not fulfilling properly this mission, as the current manufacturing process in plastic injection needs very expensive and long delivery time tooling that prevent the introduction of modifications during the development process. So the designed seals cannot be properly optimized during development, and its final performance is far from being perfect. Development times are also affected, as producing the injection tooling is a highly time consuming process. In addition, the assembly solution is neither optimum due to the geometrical limitation introduced by the molds used in injection. Additive manufacturing technologies have clear potential to solve all these issues. Despite the maturity level of specific materials for this manufacturing process, later usage in aircraft sector is very poor today. This project pretends to customize the formulation of existing materials to be processed in an optimum way by additive manufacturing technologies, for the specific purpose of aircraft operation, and with recyclable properties to make a giant step ahead in the optimization of performance of the component. Additionally, the selected manufacturing process (advanced FDM) will allow the production of multi-material seals, so the best features of current most performant reinforced seals can be reproduced, but allowing a much more complex geometry, no restriction to modification and optimization loops, and with just a fraction of its cost and its delivery time. Putting everything together, this project will drive to optimize aerodynamic performance, weight, assembly and maintenance, so less fuel consumption and pollution, maintenance costs and waste of material.

Keywords: additive manufacturing optimized tailored wing elastomeric seals
Architecting More Than Moore – Wireless Plasticity for Heterogeneous Massive Computer Architectures (WiPLASH)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Spain,Switzerland,Switzerland
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 2994765.0
EU funding (EUR): 2994765.0
Participants: 7
Project status: SIGNED

The main design principles in computer architecture have shifted from a monolithic scaling-driven approach towards an emergence of heterogeneous architectures that tightly co-integrate multiple specialized computing and memory units. This is motivated by the urgent need of very high parallelism and by energy constraints. This heterogeneous hardware specialization requires interconnection mechanisms that integrate the architecture. State-of-the-art approaches are 3D stacking and 2.D architectures complemented with a Network-on-Chip (NoC) to interconnect the components. However, such interconnects are fundamentally monolithic and rigid, and are unable to provide the efficiency and architectural flexibility required by current and future key ICT applications. The main challenge is to introduce diversification and specialization in heterogeneous processor architectures while ensuring their generality and scalability. In order to achieve this, the WiPLASH project aims to pioneer an on-chip wireless communication plane able to provide architectural plasticity, reconfigurability and adaptation to the application requirements with near-ASIC efficiency but without any loss of generality. For this, the WiPLASH consortium will provide solid experimental foundations of the key enablers of on-chip wireless communication at the functional unit level as well as their technological and architectural integration. The main goals are: (i) prototype a miniaturized and tunable graphene antenna in the terahertz band, (ii) co-integrate graphene RF components with submillimeter-wave transceivers and (iii) demonstrate low-power reconfigurable wireless chip-scale networks. The culminating goal is to demonstrate that the wireless plane offers the plasticity required by future computing platforms by improving at least one key application (mainly biologically-plausible deep learning architectures) by 10X in terms of execution speed and energy-delay product over a state-of-the-art baseline.

Keywords: graphene antennas,on chip wireless communication networks,subthz transceivers,scalable,flexible heterogeneous processor architectures,biologically plausible deep learning computing architectures
Novel Approaches for Plant Health Monitoring (PANTHEON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Iran, Islamic Republic of,Spain,Tunisia,Greece,Greece,France,United States,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1117800.0
EU funding (EUR): 1117800.0
Participants: 9
Project status: SIGNED

Agriculture must adjust to future climate change already pushing growers to constantly try to monitor plants’ health to offset yield losses. To reduce yield losses and facilitate effective management practices constant and precise monitoring of plant health is essential. Current monitoring approaches fall short in fulfilling early detection of physiological perturbations that could threaten productivity and make corrective interventions possible. In PANTHEON, our major goal is to establish approaches with unprecedented precision and sensitivity for constant monitoring of plant health focusing on Brassicaceae and Grapevine. These are important annual and perennial species, respectively, for the EU economy and among the most valuable crops in the world. We will develop remote sensing coupled with spectroscopy-based approaches allowing high spatialization of results during abiotic stress and pest diseases. We will complement these approaches with remote or lab microtechnologies, imaging sensing for label-free, fast and sensitive analysis focusing on early stress perception. In parallel, we will establish computational approaches to manage monitoring data and provide software for monitoring the plant’s health and yields. PANTHEON comprises nine partners, five academic and four non-academic partners. Academic institutions, nurseries, breeders, software developers, and other private sectors will be the main recipients of the novel knowledge and technical advances obtained. The approaches that will be developed can be adapted for monitoring the health of any important plant species, apart from Brassicaceae and Grapevine. Finally, PANTHEON is endowed with significant training activities for the training of the next generation of researchers to meet the growing demands of Academic and Industry settings.

Keywords: plant stress,plant health evaluation,plant health monitoring
CASSIO - Hybrid Electric Modular General Aviation Aircraft (CASSIO)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 3054035.0
EU funding (EUR): 2137824.5
Participants: 1
Project status: SIGNED

General aviation is on the cusp of a transformation. The arrival of hybrid electric aircraft will unleash a revolution, driven by pent-up demand for fast and convenient regional travel. Electric air will enable much faster door-to-door travel than highways or high-speed rail. And it will do this at lower cost, without need for the massive, inflexible ground infrastructure. The benefit for the environment will be equally dramatic. Voltaero SAS is a French start-up that has developed the first in the world parallel and series distributed hybrid propulsion system that will power a family of general aviation aircraft, CASSIO, with the seating capacity of four to 10 passengers. Benefitting from more than 50 years of pioneering expertise of its founders, Voltaero is taking electric aircraft to an entirely new level. A flight demonstrator have validated the CASSIO configurations in-flight and on the ground, de-risking them for airworthiness certification and the subsequent application on new-production airplanes to be built using strong, lightweight materials. CASSIO propulsion system delivers a total output of 600 kW, allowing for the flight range of up to 1,200 km in a heavy-hybrid mode, offering 3,5 hours of flight autonomy. Since most of the short-haul routes in Europe lie within the distance of 100 to 1000 km, CASSIO will become a new mode of transport that will enable access to more communities in less time, enhance regional mobility, alleviate road congestion problems, - doing it all in a safe, a customer- and environmentally-friendly way. Based on the range required by the customer and the flight profile the CASSIO aircraft will be configured for production in three modular concepts: • CASSIO 330 - four-seater aircraft (range up to 200 km) • CASSIO 480 - six-seater (range of 200 – 600 km) • CASSIO 600 - ten-seater (range of over 600 km) Fuel economy and CO2 reduction will vary from 20% in heavy hybrid mode, to 50% in mid hybrid, and to 100% in pure electric.

Keywords: hybrid electric propulsion,sustainable general aviation,low carbon emissions,more electric aircraft,eco friendly aircraft
Understanding small RNA-mediated transposon control at the level of chromatin in the animal germline (PIWI-Chrom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1999530.0
EU funding (EUR): 1999530.0
Participants: 1
Project status: CLOSED

Transposable elements—universal components of genomes—pose a major threat to genome integrity due to their mutagenic character. In all eukaryotic lineages small RNA pathways act as defense systems to protect the host genome against the activity of transposons. The central pathway in animals is the gonad-specific PIWI interacting RNA (piRNA) pathway, one of the most elaborate but also least understood small RNA silencing systems. Here I propose to study the interplay between the piRNA pathway and chromatin biology in Drosophila with two aims: First, we will identify the factors and investigate the processes that underlie piRNA-guided silencing in the nucleus. Our objective is to understand how recruitment of an Argonaute protein to a nascent RNA mechanistically leads to the assembly of effector proteins that govern heterochromatin formation and transcriptional silencing. Second, we will study the biology of piRNA clusters, heterochromatic loci that encompass a library of transposon fragments and that act as the pathway’s memory system. Our goal is to uncover how a group of proteins—several of which are germline-specific variants of basic cellular factors—enable transcription within heterochromatin and control the downstream fate of the emerging non-coding RNAs. Our work centers on the piRNA pathway in Drosophila ovaries, undeniably the model system at the forefront of the field. By combining the strength of fly genetics with the power of genome-wide approaches we will uncover how heterochromatin on the one hand governs silencing and how the piRNA pathway on the other hand exploits it to facilitate the transcription of piRNA precursors. This will reveal fundamental insights into the co-evolution of transposons and host genomes. At the same time, by studying the piRNA pathway’s intersection with chromatin biology and transcription, we expect to reveal new insights into basic principles of gene expression.

Keywords: transposon biology,heterochromatin biology
COoperative ITS DEployment Coordination Support (CODECS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Germany,Germany,Belgium,Czechia,Netherlands,Netherlands,Denmark
Call: Towards seamless mobility addressing fragmentation in ITS deployment in Europe (H2020-MG-2014_SingleStage_B, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 1584967.38
EU funding (EUR): 1584967.38
Participants: 11
Project status: CLOSED

Multifaceted research initiatives and field operational tests have proven the potential of Cooperative Intelligent Transport Systems and Services (C-ITS) to contribute to a safer, more flexible, mobile, sustainable and comfortable future society. In first deployment activities like the Cooperative ITS Corridor, SCOOP@F and COMPASS4D pilot projects,users will precociously experience the benefits of cooperative traffic safety and efficiency services, enabled by the integration of new technology (e.g. ETSI ITS G5) into vehicles and infrastructure. As a considerable stakeholder organisation, the Amsterdam Group pursues a harmonised C-ITS system realisation providing benefits to all users. It facilitates joint work for a growing variety of stakeholders such as road operators, automotive industry, cities and regions. The Coordination and Support Action COoperative ITS DEployment Coordination Support (CODECS) supports the European Commission and the manifold stakeholders involved in C-ITS deployment in finding strategic and technical policy solutions and processes for a consolidated C-ITS roll-out. CODECS serves as hub for transparent information and knowledge transfer on function approaches, experiences and lessons-learned by stakeholders active in the initial deployment. To ensure European-wide seamless (cross-border) interoperability and end-user experiences, CODECS develops a harmonised standards profile supporting a growing amount of C-ITS services. To address key organisational and technology related issues, CODECS will derive a strategic common road map from preferences of the involved stakeholders, giving direction for innovation, testing, standardisation and deployment beyond Day One. CODECS also supports future C-ITS common deployment by achieving a clear understanding on policies, roles and responsibilities. CODECS does convey these insights to the C-ITS deployment platform initiated by the European Commission and also to the Amsterdam Group.