Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Researchers’ Night 2012 in the Czech Republic: (RN2012CZ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Czechia
Call:  (FP7-PEOPLE-2012-NIGHT, 2012)
Start date: 2012-06-01
End date: 2012-12-31
Duration (months): 7.0
Total project cost (EUR): 91213.0
EU funding (EUR): 80000.0
Participants: 1
Project status: CLOSED

The concept of Researchers' Night 2012 is based on the performance of scientists as ordinary people who are in essence no different from the general public. The goal is to bring together the public at large and researchers to improve the image of researchers and to strengthen the public recognition in the scientific work in a funny way. The next goal is to stimulate young people's interest in scientific careers through this event. This year's motto is "Science does not age." It reflects the organizers' efforts to alert the public to the permanent value of scientific knowledge. Scientific research is universal and timeless. A massive amount of new information of many kinds appears every day but may quickly become outdated. On the other hand, factual approved findings which scientists have invented across the generations push the boundaries of our understanding of the world into new dimensions. During the Night, the public at large from all regions of the Czech Republic will have the opportunity to explore the scientific work, have fun and share their leisure time with the scientists. Anyone regardless of age and scientific skills will be able to participate in experiments, watch demonstrations, take part in competitions or just enjoy having fun with researchers. The role of the European Commission in supporting this particular event will be described and the EC will be presented as an institution that continuously and largely supports research Europe-wide.

Keywords: night,science,researchers,local event brokers,demonsrations,experiments,science communication,observations,popularization,lectures,exhibitions,workshops
Physarum Chip: Growing Computers from Slime Mould (PHYCHIP)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and Emerging Technologies
Action type: Collaborative project
Countries involved: United Kingdom,Italy,Austria,Germany,Poland
Call:  (FP7-ICT-2011-8, 2011)
Start date: 2013-03-01
End date: 2016-02-29
Duration (months): 36.0
Total project cost (EUR): 2716324.0
EU funding (EUR): 2099984.0
Participants: 5
Project status: CLOSED

We will design and fabricate a distributed biomorphic computing device built and operated by slime mould Physarum polycephalum. A Physarum chip is a network of processing elements made of the slime mould's protoplasmic tubes coated with conductive substances; the network is populated by living slime mould. A living network of protoplasmic tubes acts as an active non-linear transducer of information, while templates of tubes coated with conductor act as fast information channels. The Physarum chip will have parallel inputs (optical, chemo- and electro-based) and outputs (electrical and optical). The Physarum chip will solve a wide range of computation tasks, including optimisation on graphs, computational geometry, robot control, logic and arithmetical computing. The slime mould-based implementation is a bio-physical model of future nano-chips based on biomorphic mineralisation. We envisage that research and development centred on novel computing substrates, as self-assembled and fault-tolerant fungal networks will lead to a revolution in the bio-electronics and computer industry. Combined with conventional electronic components in a hybrid chip, Physarum networks will radically improve the performance of digital and analog circuits. Taking into account the enormous and growing interest of research centres and commercial laboratories in the recent experimental implementations of chemical, molecular and biological computers, we can predict that in the next 20-30 years, networks of slime mould mineralised and/or coated with compound substances will become a widespread commodity and a very promising component of novel information processing circuits.

Keywords: unconventional computing,biomorphic computing,mineralisation,novel computing substrates,hybrid chip,molecular and biological computers,novel information processing circuits
Malopolska Researchers’ Night 2012 (MAGICNIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Poland,Poland,Poland,Poland
Call:  (FP7-PEOPLE-2012-NIGHT, 2012)
Start date: 2012-06-01
End date: 2012-11-30
Duration (months): 6.0
Total project cost (EUR): 193077.6
EU funding (EUR): 125000.0
Participants: 11
Project status: CLOSED

The impossible becomes possible on one particular night of the year! On 28 September 2012, all persons participating in Malopolska Researchers’ Night 2012 will be able to pass through the door of the future to discover the incredible present and go on a breath-taking scientific trip through time and space. Malopolska Researchers’ Night 2012 will be held in four of the Region’s cities/towns: Krakow, Tarnow, Nowy Sacz and Niepolomice. With their huge scientific potential, these centres put Malopolska at the forefront of regional innovation in Poland. Malopolska Researchers’ Night 2012 is targeted mainly at children and teenagers. We want to show them how fascinating the research work can be. In a fun atmosphere, we will attempt to overcome the traditional stereotype of the researcher as a person whose “head is in the clouds” and who has “little touch with reality”. During the Night everybody will have the chance to meet face to face with researchers and see for themselves what fascinating individuals they are: full of passion, having a variety of interests yet dedicated to their work and investing immense efforts in the advancement of science. In 2012, Malopolska Researchers’ Night will be organised on an unprecedented scale thanks to the involvement of 15 Partners and 24 supporting institutions. 41 locations in Malopolska will be available to the public. Around 80 workshops, 108 shows and demonstrations and over 50 lectures will be hosted by 36 faculties/departments. Researchers will provide tours of as many as 50 laboratories and 19 exhibitions. Nearly 30 competitions and games will await the youngest participants. There will also be a wide choice of accompanying events: 8 theatre and cabaret performances by researchers, a music concert and multimedia shows. Nearly 700 researchers, over 300 students and 50 students’ associations will take the public on this incredible scientific journey.

Keywords: performance,laboratory,experiments,night,researchers,innovation
Carbon dynamics in Pyrenean grasslands: a first-time assessment with ecosystem fluxes, isotopic marking, and plant guilds (CAPACITI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-07-01
End date: 2013-06-30
Duration (months): 24.0
Total project cost (EUR): 232480.0
EU funding (EUR): 232480.0
Participants: 1
Project status: CLOSED

Given the vulnerability of mountain ecosystems and their importance as carbon storage systems, there is a pressing need to understand how mountain grassland ecosystems function –with the aim to asses the impact of global change and to determine the management mechanisms that can ameliorate its effects. This proposal focuses on the study of the annual C dynamics of semi-natural grazed grasslands in the Pyrenees. The central question will be to resolve how management and climate combine to regulate their productivity and carbon storage capacity. This will be pursued with multi-site analysis of ecosystem dynamics from eddy correlation towers data (description of annual cycles and main biotic and abiotic controlling factors, annual carbon balance, partition of ecosystem fluxes), process understanding (compartment functioning through stable isotope analyses and gas-exchange chambers), and exploration of process-based relationships to evaluate C balance in mountain pastures. Emphasis on the potential role of plant guild distribution as ecosystem regulators will be transversal to all activities. Dr Altimir will be hosted for a 24-month visit at the Technological Forestry Centre of Catalonia (Spain), where she will join the research at the Laboratory of Functional Ecology and Global Change. This group offers experience in grassland ecology as well as cooperation with isotope researchers. The groups coordinates the transnational and interdisciplinary project FLUXPYR and its unprecedented multi-site network for the integrated study of the carbon, energy and water cycles in the Pyrenean agro-ecosystems. Dr Altimir will receive training for an advance career level, emphasizing on project management and supervision skills. She will be also specifically trained for the use isotopic techniques, and guided in the characterization of plant guilds. Secondarily, she will be instructed in the application of remote sensing techniques as validation tools for ecosystem models

Keywords: carbon cycle,plant physiology,mountain ecosystems,biogeochemistry,climate change,plant ecology
Understanding the variable and transient non-thermal emission of Galactic sources (NONTHERMTRANSIENTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-11-28
End date: 2014-11-27
Duration (months): 36.0
Total project cost (EUR): 247257.6
EU funding (EUR): 247257.6
Participants: 1
Project status: CLOSED

The past decade has witnessed high-energy astrophysics make great leaps in scientific discovery and the capabilities of instrumentation. Soft and hard X-ray telescopes from 0.1 – 150 keV have yielded whole new source populations and shed light on fundamental physics questions. The current generation of air Cherenkov telescopes have successfully surveyed TeV emission from the Galactic plane revealing a population of the most energetic sources in our Galaxy. We now stand on the threshold of a new era of discovery; the recent launch of the Fermi Gamma-ray Space Telescope has made many exciting, early discoveries in the 0.1 – 300 GeV energy range. Entire new variable and transient Galactic source populations have been discovered opening totally new fields of investigation. Combining the capabilities of Fermi with the upcoming fast radio survey of LOFAR and the detailed hard X-ray telescope NuSTAR will allow for the most detailed study of non-thermal timing and spectral properties of Galactic sources ever possible. Fermi neatly covers the gap between the hard X-ray and VHE (TeV) energy ranges so that we will have sensitive instruments operating simultaneously over the whole band for the first time. Enacted, this research project, will exploit these instruments together with advanced Bayesian data analysis methods to radically advance our knowledge of particle acceleration physics in Galactic shocks and jets, the extreme environments in which such acceleration is possible and the origin of cosmic-rays.

Keywords: physical sciences,astrophysics
Degradative potential of rivers as a key driver of the environmental fate and sink of organic pollutants (DEGRAPOLL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-11-01
End date: 2013-10-31
Duration (months): 24.0
Total project cost (EUR): 173880.8
EU funding (EUR): 173880.8
Participants: 1
Project status: CLOSED

The great “riverine input-output paradox” is that even though the inputs of organic pollutants in rivers are enormous by point and non-point sources, the levels of pollutants in rivers are moderate and the final amount and impact of organic pollutants that reach the sea is small in comparison to other processes transporting pollutants to the marine environment Therefore, there is a need to study the degradative potential of rivers (and other sinks such as volatilization) in order to understand and predict the role that rivers play in the biogeochemical cycling of organic pollutants at regional scale. The main aim of the research proposed here is to contribute in the rise of knowledge about the degradative potential of rivers as driver of environmental fate and transport of organic pollutants during longitudinal transport. Specifically, it will contribute to shed the light on the issue of transformation products and abiotic and biotic degradation in rivers using selected representative organic pollutants covering a wide window of physical chemical properties in microcosm experiments in the laboratory and in the field . The impact of transformation products has been more or less ignored in terms of modelling. Work is required to develop the appropriate modelling strategies to assess potential risks and role of these substances. This research will contribute to the knowledge of the impact of organic pollutants in riverine systems and provide modelling tools to predict the ultimate fate and transport of these pollutants to other media (seas and atmosphere).

Keywords: natural sciences,environmental science,water science,water quality monitoring
How is phosphoinositide 3-kinase beta regulated by G-Protein Coupled Receptors and by Rab-5? (BETA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-01
End date: 2013-12-31
Duration (months): 24.0
Total project cost (EUR): 209092.8
EU funding (EUR): 209092.8
Participants: 1
Project status: CLOSED

Many signaling pathways in human cells involve lipid recognition events. The phosphorylation state of these lipids is under the control of both lipid kinases and lipid phosphatases. The phosphorylated second messenger lipids recruit lipid adaptor molecules, which regulate fundamental cellular processes including cell survival, proliferation, motility, differentiation and intracellular trafficking. Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3’ hydroxyl group of inositol phosphate. The class IA PI3K family is associated with diseases including cancer, thrombosis, allergies and arthritis. Although it is clear that these PI3Ks are activated by Receptor Tyrosine Kinases (RTKs), PI3Kβ is the single member of the PI3Ks that is activated downstream of both RTKs and G-protein coupled receptors (GPCRs). Using a combination of X-ray crystallography, in vitro activity assays and cellular experiments, I want to characterise the mechanisms specific to PI3Kß regulation. A first step will consist in the determination of PI3Kß structures in complex with G-protein ßγ heterodimers and with the small GTPase Rab5. That structural information will serve as an invaluable framework for further design of in vitro and cellular experiments to interrogate the exclusive mechanism of PI3Kβ regulation. Because of the potential role of PI3Kβ in oncogenesis and thrombosis, I will also determine the structures of PI3Kß in complexes with a panel of PI3K isoform-specific inhibitors. These structures will provide the basis for the next generation of therapeutics. This project will weave threads of structural, biophysical, biochemical and cell biology into a tapestry that depicts the roles of this unique enzyme that stands at the cross-road of RTK and GPCR signalling.

Keywords: natural sciences,molecular biology,structural biology,cell biology,functional biology
Education and Time-Preference: Causation, Consequences and Intergenerational Effects (EDTIMEPREF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 195887.2
EU funding (EUR): 195887.2
Participants: 1
Project status: CLOSED

The scientific content of this research project is concerned with understanding the complex interactions between education, time-preference, mental health outcomes and the transmission of these factors between parents and their children. The research will move our understanding beyond the mapping of correlations between these factors, exploiting large datasets from a number of EU countries, allied with state of the art econometric methodologies, to establish the strength of the causal relationship between education and an individual’s own time-preferences, the time-preferences of their children and the individual’s mental health. Building on the Fellow’s current research skills, experience and competencies, the Fellowship will significantly advance the Fellow along the career path towards securing a leading academic position. The Fellow will be provided with a new and stimulating research environment, working alongside the leading academics in the research field, gaining technical training in new methodologies and being exposed to policy experiment evaluation studies unique to the Geary Institute at University College Dublin. Advanced formal training in complementary skills, plus the technical skills gained and practical experience of project management, will contribute to a rounding of the Fellow’s skill portfolio. The significant advancement of the Fellow’s skills will place him in a position to exploit future funding opportunities in the EU as numerous nations implement policy experiments which will require highly skilled quantitative social scientists to evaluate. The Fellowship is the next coherent step in the Fellow’s research career progression and will position the Fellow to secure a tenured position at a leading European research institution. Going forward, exposure to the international network of academic, policy and industry collaborations at the GI, the Fellow will contribute to increased mobility and knowledge transfer in the European Research Area.

Keywords: social sciences,economics,education,time-preference,mental health
The association between type 2 diabetes diagnosis and diabetes medications with risk of cancer (DIABETES AND CANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 157720.0
EU funding (EUR): 157720.0
Participants: 1
Project status: CLOSED

Type 2 diabetes and cancer are two chronic diseases that negatively influence the survival of millions of people worldwide. Diabetes has been shown in meta-analyses to be associated with an increased risk of several cancers, but these associations are not yet documented as causal. The evidence for specific diabetes drugs affecting cancer risk is limited, because randomized clinical trials are not designed to evaluate specifically cancer outcomes, and observational studies are often confounded by indications for specific drugs. We propose to better characterize the degree of involvement of type 2 diabetes diagnosis and pharmacologic treatment in cancer initiation or progression. Therefore, we will a) evaluate bias and credibility in the existing meta-analyses of diabetes diagnosis and cancer risk, b) determine whether diabetes diagnosis is associated with risk of prostate cancer using the European Prospective Investigation into Cancer and Nutrition cohort, c) perform a systematic review and meta-analysis of randomized clinical trials and observational studies that have evaluated the association between diabetes medications and cancer risk, and d) evaluate the association between diabetes drugs and cancer risk (separately by site) using the UK-based General Practice Research Database. Cutting-edge evidence synthesis methods (Harbord’s test, excess significance bias test, credibility ceilings) will be used in our first aim, and summary meta-analytic estimates will be calculated in our third aim using random effects models. An incident diabetes drug cohort design with adherence-adjusted intention-to-treat style of analysis will be used in aim 4, while Cox proportional hazards models will be used in both aims 2 and 4. The proposed project will have major impact in the field, because the literature on diabetes diagnosis, treatment on cancer risk will be properly evaluated, and these associations will be further assessed in two large, unique prospective studies.

Keywords: health sciences,public health,cancer epidemiology,meta-analysis,cohort study,type 2 diabetes,cancer,diabetes medications
Binuclear Non-Coupled Copper Enzymes in Neurobiology: An Integrated Computational/Spectroscopic Investigation (ITCSCEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-05-16
End date: 2014-07-31
Duration (months): 36.0
Total project cost (EUR): 258386.8
EU funding (EUR): 258386.8
Participants: 1
Project status: CLOSED

Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research. In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods.

Keywords: bioinorganic chemistry,bioinorganic spectroscopy,computational chemistry