Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
GI.service: Asset performance optimiser (GIservice)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Austria
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global energy market is changing from a central supply concept to a decentralized system, resulting in changes in investments at various levels. For example, in 2015, for the first time ever, investments in renewable energies were higher than in conventional energies (fossil, nuclear). Since 2011, approximately €281 billion have been invested annually in renewable sources. Many established energy supply companies are also changing their strategy and want to focus on renewable energy generation, service and sales. GI.service will suppose a step ahead in the state of the art of Energy Management Systems (EnMS). The main asset is its superior degree of accuracy in measurements, which is reached by the combination of our proprietary HW measuring devices and our in-house SW modules for data acquisition, storage, analysis and exploitation. Based on this capacity, we have been able to create a unique set of features that are not offered by the alternatives in the market for the optimisation of: power generation plants (up to 10% more production and risk reduction), second life of high-capacity used batteries (up to 8% better capacity utilization), energy distribution grids (up to 10% more efficient and optimized), energy-related assets (up to 15% longer lifespan of assets) and other advanced features for decision making on energy efficiency and assets. The targeted field is promising: the global EnMS market is expected to grow from €20.76 billion in 2015 to €52.76 billion by 2020, at a CAGR of 20.5%, with the industrial applications supposing 60% to 70% of this market. In addition, the global market of energy generation supposes a convenient scenario for the commercialisation of GI.service, with a total size of €1,900 billion. Especially relevant is the renewable energies market, forecasted to grow 40% in the next 15 years.

Keywords: energy efficiency,transforming energy industry,smart grid technology,internet of things energy
Biomimetic nano-coatings for healthcare. Targeting the contact lenses market (LIPOCOAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Biofouling, i.e. the formation of deposits of biomolecules or even bacteria in the surface of the medical device, is the main cause of the loss of the devices performance. LipoCoat’s patented nano-coatings make use of lipid bilayers to prevent biofouling of medical devices when placed into contact with bodily fluids in- or outside of the body. Our natural and bio-inspired coating makes use of molecules found in every cell, making it extremely biocompatible. The neutral LipoCoat molecules can efficiently attract water thus preventing any interaction with proteins and cells. Furthermore, LipoCoat can stably apply these layers using our proprietary LipoCoat FAST manufacturing process. Among the wide range of biomedical applications for LipoCoat nano-coatings, we decided to target the contact lenses as it presents a clear business opportunity (a € 11.4 billion global market with a projected CAGR of 7-10% 2014-2019). Demo studies, both in vitro and in vivo, have demonstrated the LipoCoat coating efficiency and its benefits on contact lenses: 95% reduction in bacterial adhesion, improved wetting and lubricity and comfort improvement. In view of these promising results, we were able to establish close ties with leading national and international CLs manufacturers. The next step for LipoCoat’s commercial success on the contact lenses market, which comprises the main objective of this project, is the industrialization of our proprietary manufacturing process to scale-up the production of LipoCoat nano-coatings. We expect a time-to-market of 2 years, launching our product on the CLs market by 2020. Our initial sales forecast estimates a cumulative cash flow of € 32.2 million after the five first years of commercialization. The estimated investment needed, € 2 million, will be recovered after only two years, and the estimated ROI after the fifth commercialization year is 16.2%.

Keywords: coatings,nano coatings,nanotechnology,medical devices,biomimetic,bioinspired,biofouling,contact lenses,catheters
Mid-infrared optical dual-comb generation and spectroscopy with one unstabilized semiconductor laser (ONE-MIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 3210000.0
EU funding (EUR): 3210000.0
Participants: 1
Project status: SIGNED

ONE-MIX proposes to develop single-source dual-comb lasers for mid-infrared (2-5 μm wavelength) spectroscopy, potentially enabling many new applications in science and industry, such as environment, safety, pharma, and health. This proposal extends our recent demonstration of a dual-comb MIXSEL (Modelocked Integrated eXternal-cavity Surface Emitting Lasers) in the near-infrared, validated by measuring weak water absorption at 968 nm. Many more relevant gas absorption lines, however, are in the mid-infrared, where sensitivities of parts-per-billion can be achieved. Dual-comb mid-IR spectroscopy applications are currently limited by the cost, complexity, and size of conventional optical comb systems, based on two modelocked lasers with four active stabilization loops. The single-source dual-comb MIXSEL, however, substantially reduces the complexity of existing systems to a single compact free-running laser. In comparison to other competing new approaches such as quantum cascade lasers or micro resonator combs, the MIXSEL provides substantially more power per comb line with low linewidth and noise, and is ideally suited for a 1 to 5 GHz comb spacing, which is optimal for many molecular spectroscopy applications, allowing for fast, accurate, and sensitive absorption measurements. This proposal leverages our know-how in MIXSEL design combined with III-V semiconductor epitaxy to demonstrate this new class of lasers in the mid-IR, enabling simpler, lower-cost systems with sufficient speed and sensitivity for many relevant and commercially interesting applications in the 2 to 5 μm spectral region, such as CO2 , CH4, or NOx trace gas detection. We propose to extend the near-IR MIXSELs to the mid-IR by combining two validated semiconductor approaches – using type-II gain quantum wells combined with a type- I saturable absorber quantum wells, fabricated with existing GaSb (gallium-antimonide) molecular beam epitaxy systems operated out of the FIRST lab at ETH Zurich.

Keywords: passive mode locking,surface emitting semicondutor lasers,mid infrared molecular spectroscopy,frequency metrology,optical frequency combs
REESources: experimental investigation of the role of fluids in the formation of rare metals ore deposits. (REESources)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

High-field strength elements (HFSE: Ti, Zr, Nb, Ta, Hf) and rare earth elements (REE: La to Lu, +Sc, Y) have become critical resources to the industry, being labeled the ‘keys to green technologies’. Their rarity does not stem from their low abundance in the Earth’s crust but rather from difficulties in separating them from each other and China’s monopoly on their supply chain. Strikingly, little is known about the geological processes leading to their economic concentration in different environments. Especially, how high-temperature fluids can extract rare metals from magmas and reconcentrate them up to economic levels is poorly understood. The proposed research will investigate this question combining innovative experimental technics. High-pressure high-temperature experiments will be conducted at the Institute for Mineralogy at the University of Münster (WWU) and different synchrotron facilities (ESRF, Grenoble; PETRA, Hamburg) to determine the solubility, speciation and fluid-melt partitioning of the HFSE and REE. The experimental results are expected to constitute a necessary theoretical framework for the exploration and sustainable mining of these critical metal resources. The applicant has 9 years experience of experimental petrology, with particular expertise in the in situ study of high P-T fluids with synchrotron radiation and Raman spectroscopy. Especially, she has been working on the role of fluids in the formation of various ore deposits over the last 4 years (at the Australian National University and the University of Bristol). The WWU would benefit from the applicant’s previous research experience in in situ technics, X-ray and Raman spectroscopies and in the field of economic geology. In return, the applicant will receive crucial support to develop her research and especially benefit from the comprehensive experimental and analytical environment at WWU, which is one of Europe’s leading research institutes in Petrology and Geochemistry.

Keywords: experimental geochemistry,high temperature fluids,in situ raman,in situ xas,synthetic fluid inclusions,hfse,rare metals deposits
HEAT PUMPS SKILLS FOR NZEB CONSTRUCTION (HP4All)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Spain,Ireland,Italy,Spain,Ireland,Belgium
Call: Stimulating demand for sustainable energy skills in the construction sector (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 996286.25
EU funding (EUR): 996286.25
Participants: 8
Project status: CLOSED

HP4All brings together leading experts across Europe to enable capacity and skills development within the Heat Pump sector and to ensure that the energy efficiency gains afforded by heat pumps are realised. HP4All, following a a holistic, systemic point of view, will work both with the supply side (manufacturers, SMEs, installers etc) and demand side (building owners, public sector etc.). This way, the project will enhance, develop and promote the skills required for high quality, optimised Heat Pump (HP) installations within residential/non-residential buildings bringing Europe to the forefront of the climatization sector. HP4All will develop the HP4All package, a set of different tools and resources to be used by the different related stakeholders. The package includes a HP Competency Framework to facilitate Mutual Recognition of HP Skills and, from an end user perspective, a HP Knowledge Hub will be created to provide guidance, support and tools e.g. procurement guidance to increase the demand for HP skills and knowledge. HP4All will validate this package through 3 regional plans being implemented (AT, ES and IE) with the ambition of driving market change, influencing end user decisions and planning for new innovations. The implementation plans will be informed by extensive stakeholder engagement to map current and future barriers to HP market exploitation and skills development. Leading experts in the HP and Energy sector will support the regional actors to prepare the market for new innovations related to HP technology, procurement and contracting services. The impact of the project will be maximised through the role of the Observers (HR, PT,RO ) as they will follow closely the development and validation of the HP4All package, being early adopters even before the project ends. Replication activities will include train-the-trainer, a roadmap and pan-European events for policy makers and public bodies.

Keywords: heat pumps,buildings,knowledge,competency,skills
Diamond based nanomaterials for biosensing applications (DNA-BIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Japan
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 204847.68
EU funding (EUR): 204847.68
Participants: 2
Project status: SIGNED

This proposal is a 24-month Marie Curie Global Fellowship scheme which involves a British experienced researcher to undertake a training-through-research project on the development of cutting-edge diamond based nanomaterials for biosensing applications (DNA-BIO) in liaison with National Institutes for Materials Science (NIMS), Japan. Dr. Haitao Ye has been conducting original research into diamond growth and characterisation and device fabrication at University of Leicester (UoL), and has established an excellent track record. NIMS is a world-leading research institution in the field with an international reputation of technological innovation, enterprise participation, and knowledge transfer. The proposal will tackle the challenging development of multifunctional nanodiamond species and assess their applications to bioimaging and sensing. Success will deliver new approaches for both surface functionalisation and doping of nanodiamonds and bring high-resolution bioimaging sensors to the research community. It will contribute to the EU’s economy by developing next-generation biomedical sensor and significantly widening the competences of the fellow to reach his professional maturity with interdisciplinary expertise and complementary skills unique to the ERA. The fellow is leading the development of UoL’s teaching and research activities in surface engineering and biomaterials and the highest quality training under supervision of internationally leading scientists is indispensable for his career development which will in turn benefit the UK and the EU.

Keywords: materials process,surface functionalisation,sensor
Systematic Decoding of Deubiquitylase-Regulated Signaling Networks (DUB-DECODE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 1972570.0
EU funding (EUR): 1972570.0
Participants: 1
Project status: CLOSED

Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology. Ubiquitin is a small, evolutionarily conserved signaling protein that acts as a PTM after being covalently conjugated to other proteins. Reversible ubiquitylation forms the most versatile and largest eukaryote-exclusive signaling system, and regulates the stability and function of almost all proteins in cells. Deubiquitylases (DUBs) are ubiquitin-specific proteases that remove substrate-conjugated ubiquitin, and thereby regulate virtually all ubiquitylation-dependent signaling. Because of their central role in ubiquitin signaling, DUBs have essential functions in mammalian physiology and development, and the dysregulated expression and mutation of DUBs is frequently associated with human diseases. Despite their vital functions, very little is known about the proteins and ubiquitylation sites that are regulated by DUBs and this knowledge gap is hampering our understanding of the molecular mechanisms by which DUBs control diverse biological processes. Recently, we developed a mass spectrometry-based proteomics approach that allowed unbiased and site-specific quantification of ubiquitylation on a systems-wide scale. Here we propose to comprehensively investigate DUB-regulated ubiquitin signaling in human cells. We will integrate interdisciplinary approaches to develop next-generation cell models and innovative proteomic technologies to systematically decode DUB function in human cells. This will enable a novel and detailed understanding of DUB-regulated signaling networks, and open up new avenues for further research into the mechanisms and biological functions of ubiquitylation and of ubiquitin-like modifiers.

Keywords: ubiquitin signaling,deubiquitylases,mass spectrometry,quantitative proteomics
Understanding transcriptional regulation in plant PAMP-triggered immunity (transcriPTIon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-21
End date: 2018-09-20
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host lab and institution in new techniques, scientific communication, and international collaboration make this an ideal opportunity to prepare me for a future as an independent research leader.

Keywords: plant pattern triggered immunity,transcription factor regulation
Multiparametric imaging of glioblastoma tumour heterogeneity for supporting treatment decisions and accurate prognostic estimation (GLIOHAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

Glioblastoma is not only the most frequent but also the most malignant tumour originating in the Central Nervous System. Due to the extremely complex and heterogeneous molecular biology of this tumour “the same treatment for all” approach does not work well in this disease, and standard of care is not always the best option. The intra-patient tumor heterogeneity is one of the responsible factors for the high aggressiveness of these lethal solid tumors and their resistance against effective therapies. In this context, additional efforts are needed for generate novel strategies able to define more tailored personalized treatments that facilitate higher safety and efficacy for relevant sub-populations. GLIOHAB project will develop an artificial intelligence based medical device able to monitor the functional state of the glioblastoma at pixel level. This software will be built on technologies previously co-developed, validated, and patented by the researcher. GLIOHAB will join best experts in the field, in a multidisciplinary and eminently clinical environment, which will provide the optimum conditions for a holistic approach to the solution. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. GLIOHAB results will contribute to monitor the response of highly aggressive tumours to complex treatments, and generate stratification strategies to select treatment responder patients.

Keywords: multiparametric imaging,unsupervised learning,brain tumours,magnetic resonance imaging,prognostic