Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AntifeRromagnetic spin Transport and Switching (ARTES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Magnetic materials and devices play a tremendous role in information technology to meet current societal challenges. Antiferromagnet (AFM) spintronics is considered as a disruptive approach, enabling scalable and efficient spintronic devices. Ultimate stability and speed, combined with recent observations, e.g. the enhancement of the spin current transport when a thin AFM layer is sandwiched between Yttrium Iron Garnet and Pt, and along with theoretical predictions of superfluid spin transport, indicate significant untapped potential of this class of materials. I tackle the key open questions on spin transport in AFMs: (i) To develop and employ an all-electrical read-out of the Néel vector. The Néel vector can be set, by studying AFMs across the spin-flop field, and then compared with the resulting magnetotransport signal. In collinear antiferromagnetic conductors, the anisotropic magnetoresistance/planar Hall effect will be used, while in these and others collinear AFMs, a read-out by the Spin-Hall Magneto-resistance (SMR) at the interface between the AFM and a heavy metal will be employed, e.g. in NiO/Pt and MnN/Pt. The SMR will be additionally correlated with direct imaging of the AFM domain structure, performed in synchrotrons. (ii) To explore a new writing method, based on the voltage control of magnetic properties, via the migration of oxygen ions, as demonstrated in ferromagnets, where the anisotropies can be tailored. (iii) To transport spin in antiferromagnets. By thermally generating spin currents via the spin Seebeck effect, I will study the transport in AFM metals and insulators. Temperature-dependent measurements allow us to ascertain the role of the different spin current magnon modes. Finally, the spin injection in NiO and the exciting predicted spin superfluidity in AFMs will be probed. This work is expected to be important, not only to understand the rich physics of spin transport in AFMs, but also toward using AFMs for novel spintronic devices.

Keywords: magnetoresistance,magnons,spin currents,antiferromagnetic spintronics,spin seebeck,spin hall effect,voltage control of magnetism,spin superfluidity
Dissecting the role of mitochondrial dynamics in pancreatic carcinogenesis (OPEN P-CAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

OPA1 Educates the Nucleus in Pancreatic CANcer. Pancreatic cancer represents an unresolved health burden, showing abysmal chances of survival and refractoriness to conventional and immunological therapies. Significant benefit will be gained from a better understanding of molecular mechanisms leading to cancer formation, with the goal to curtail disease incidence and improve the opportunities to treat it early. The study will describe how mitochondria and nuclei communicate to facilitate pancreatic cancer initiation. Building from my prior research in metabolic-dependent histone acetylation, and leveraging on the host laboratory expertise in mitochondrial dynamics, I designed a roadmap for the study of how mitochondrial activity is altered during pancreatic carcinogenesis and whether that can be exploited for therapeutic purposes. I will decipher the specific role of major cristae-remodeling factor OPA1, which is an unfavorable prognostic factor for pancreatic cancer patients. I will seek how OPA1-altered expression impacts mitochondrial function and metabolite availability in mouse pre-malignant cells, using in vivo models of pancreatic carcinogenesis. My previous experimentation found that metabolite-dependent histone acetylation is critical for the initiation of pancreatic carcinogenesis. I will now investigate whether OPA1-mediated mitochondrial rewiring impacts citrate and acetyl-CoA abundance in a way that alters the levels of histone acetylation. Epigenetic reprogramming will be further investigated in various OPA1 transgenic mice. Finally, the therapeutic potential of OPA1 targeting will be addressed using both genetic and chemical approaches using resources recently developed at the host laboratory. The project represents a career-defying framework for the study of molecular determinants of pancreatic cancer onset.

Keywords: mitochondria,acetyl coa,citrate,histone acetylation,pancreatic cancer
A breakthrough laser-based medical device to eradicate bacterial biofilm in chronic wounds and accelerate wound healing. (LASER-HEAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic wounds affect 10M in Europe and 6.4 million people in the US, with annual costs of >€72Bn in Europe and >€22 Bn in the US. It is a silent epidemic. Key to this problem is the lack of truly effective solutions that fully eradicate bacteria-protecting biofilms deep within chronic wounds. We have a game-changing new solution to tackle this problem: LASER-HEAL. LASER-HEAL is a medical device that consists of 1) a laser-generating unit that can reach deep within wounds; 2) optomechatronics to move the laser in a controlled manner and 3) software to recognize the contours and depth of wounds. LASER-HEAL enables, for the first time, non-invasive, safe, low-cost (€1.000 p/treatment), rapid (30 mins/session, total ~12) treatment, compatible with standard of care. We have preliminary data showing killing of all relevant species of bacteria, while human skin cells are left intact. We will bring LASER-HEAL to the global wound care management market (€29bn in 2017 expected to reach €39bn by 2024). We will respond to the need of this market by delivering an effective antibiofilm device for chronic wounds. We will commercialize LASER-HEAL through sales to US clinics first, through fast FDA approval and confirm willingness to pay. By 2025, we will demonstrate revenue potential for LASER-HEAL, and seek a commercial exit, through acquisition (preferred) by a major medical device company, who will then bring LASER-HEAL to the European and global markets. Cumulative income of €75 million is predicted for LASER-HEAL by 2025 during this phase. We have a unique proposition, backed by preliminary results and the interest of a major wound care company (confidential for this abstract). We want to undertake a detailed study to map successful market introduction for LASER-HEAL. Funding from SMEi Phase can support us with obtaining crucial market, regulatory and de-risked development informa

Keywords: chronic wounds,chronic wound healing,biofilm,medical device,laser
Navigating lymphatic formation and function in health and disease (LymphMap)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

For many years, lymphatic vessels have been viewed as inert fluid conduits whose open structure allows for passive flow of antigens, proteins and cells from peripheral tissues to lymphoid organs. Yet, recent discoveries highlighting novel functions and heterogeneous origins of the lymphatic endothelium, call for reevaluation of the passive lymphatic-vessel paradigm. During the past decade, we have used the zebrafish (ZF) to detail the cellular and molecular events underlying the development of the lymphatic system. Our discoveries have greatly contributed to our understanding of the origins, specification and mechanisms of formation of lymphatic endothelial cells (LECs) in the developing embryo. In line with our past achievements, we now aim towards novel directions- to transform the adult ZF into an equally convenient model for the study of lymphatic diversity. The overall goal of LymphMap is to reveal the multiple regulatory levels that coordinate the formation and functionality of lymphatic vessels in health and disease. To this end, we will carry out a comprehensive research program characterizing four distinct aspects of lymphatic biology: 1.Cellular origins and molecular signature of LECs 2.Formation and specialization of organotypic lymphatics 3.Lymphatic vessels during organ regeneration 4.Lymphatic involvement in human disease Our experimental strategy involves the combination of high-resolution imaging, global expression profiling and regeneration models in adult ZF, with analyses of human-derived LECs in various clinical settings. The important and unique aspects of our approach are the focus on in vivo dynamics, and the cross-organ comparative analysis, which will likely provide the much-needed knowledge on lymphatic diversity in health and disease. When completed, we anticipate that this work will be part of a new paradigm – no longer perceiving lymphatics as passive bystanders, but rather as orchestrators of tissue morphogenesis and regeneration.

Keywords: lymphatic,zebrafish,regeneration
Factory of the Future Clusters (FOCUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Coordination and support actions
Partnership: FoF (cPPP)
Countries involved: Italy,Italy,Germany,Spain,Italy,Belgium,Norway,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Support for the enhancement of the impact of FoF PPP projects (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 324794.0
EU funding (EUR): 324794.0
Participants: 13
Project status: CLOSED

Proposal abstract The FOCUS project will build upon the fundament of five existing FoF Clusters, Zero Defect Manufacturing (4ZDM), Robotics, Clean factory, Precision Micro Production Technologies (High Micro) and Maintenance and support. They will work toward the following four objectives. 1. Provide pro-active support to the projects in the participating clusters to disseminate the project’s tangible outcomes to raise the awareness and thus increasing on a short term the industrial exploitation and take-up (“As-is”). 2. Elaborate on the common ground of the clusters to establish a European state-of-the-art and world-wide technology watch to inform the European manufacturing industry constantly while also formulating (with support from cluster specific top-ranked experts) the future FoF priorities based upon jointly identified business trends and market prospects (“As-is”). 3. Deliver a proven model and associated methodology for effective cluster creation, execution and monitoring based upon the experience of the five participating clusters in FOCUS. This methodology will considerably ease the process of creating cluster thus maximizing the possibilities of increasing the impact of ‘exploiting’ cross-project synergies (“To-be”). 4. Deliver a model and associated methodology to ensure industrial exploitation and industrial take-up for future projects including guidelines for all stakeholders including the European Commission, project initiators and partners (“To-be”). The final outcome of Focus will be: • FOCUS model for clustering and industrial exploitation known at relevant stakeholders • Methodology for clustering • Methodology for industrial exploitation & take-up • Lesson learnt from the existing clusters

Keywords: clusters,methodology,exploitaion,manufacturing,zero defects,clean factory,robotics,high presicion manufacturing and maintainance
Micro-level Politics of Peace (MICROPOLPAX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

Peace settlements are elite pacts that ignore the views of the population, those most affected by the conflict, which leads to a lack of buy-in for sustainable peace. The project “Micro-level Politics of Peace” (MICROPOLPAX) puts individuals at the centre of the focus and asks what peace means to individuals. The framework has universal relevance but will be tested in the timely case of Ukraine, a country currently undergoing conflict in the European Union’s near abroad and of geopolitical significance to the EU. The project is interdisciplinary and methodologically plural, using mixed methods of qualitative interviews and the rigorous methods of survey experiments. The action allows for the two-way transfer of knowledge, combining the experienced researcher’s learning on norm diffusion and political psychology with the supervisor’s expertise on micro-level dynamics of conflict. The training-through-research gained will enable the applicant to open up this new research area and become an independent and skilled researcher. The action will generate academic dissemination through conferences, articles, open-access data and a specialist seminar. The action will also provide policy exploitation for the EU, peace negotiators and for democracy activists in Ukraine. Throughout the action, the project will take advantage of many types of public engagement, such as blogs, web-based games, World Peace day and International Women’s Day.
Integrated Control and Sensing for Sustainable Operation of Flexible Intensified Processes (CONSENS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Germany,Germany,Germany,Belgium,France,France,France,France,Netherlands
Call: Integrated Process Control (H2020-SPIRE-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 5997550.0
EU funding (EUR): 5997550.0
Participants: 16
Project status: CLOSED

Intensified continuous processes are a key innovation of the last decade for the production of high quality, high value and customer-specific products at competitive prices in a sustainable fashion. To realize the potential of this technology, key steps must be made towards long-term stable, tightly controlled and fully automated production. The goal of the CONSENS project is to advance the continuous production of high-value products meeting high quality demands in flexible intensified continuous plants by introducing novel online sensing equipment and closed-loop control of the key product parameters. CONSENS will focus on flexible continuous plants but the results will be transferable also to large-scale continuous processes. The research and development is driven by industrial case studies from three different areas, spanning the complete value chain of chemical production: complex organic synthesis, speciality polymers, and formulation of complex liquids. Innovative PAT technology will be developed for online concentration measurements (mid-resolution process NMR), for the online non-invasive measurement of rheological properties of complex fluids, and for continuous measurements of fouling in tubular reactors. New model-based adaptive control schemes based on innovative PAT technology will be developed. The project results will be validated in industrial pilot plants for all three types of processes, including validation in production containers that have been developed in the F3 Factory project. Further, methods for sensor failure monitoring, control performance monitoring and engineering support for PAT-based solutions will be developed. The exploitation of the new technologies will be facilitated by a tool for technology evaluation and economic impact assessment. A Cross-sectorial Advisory Board supports the transfer of PAT technologies and adaptive control to neighboring sectors of the European processing industry.

Keywords: continuous intensified modular processing and production sensors ultrasound rheology composition nmr
Multitarget compounds with therapeutic potential against Alzheimer disease: Design and in vitro studies (CHELALZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-04-22
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This fellowship will provide a prolific researcher with an internationally competitive, multi-disciplinary research training at the Chemistry/Biology interface in an EU leading Bioinorganic chemistry team, preparing her to obtain her goal of a faculty position in the EU and her own research team in Medicinal Chemistry. She will develop novel anti-Alzheimer conjugates that target multiple disease's hallmarks. Afterwards she will evaluate their in vitro therapeutic and diagnostic potential through a secondment with cell biologists in another EU country, the United Kingdom. This research will pave the way towards the development of innovative and effective anti-Alzheimer drugs by using versatile drug combination approaches to fight this horrible and still incurable disease. Alongside her research she will also acquire research management, leadership, presentation and teaching skills to prepare her for a successful future as an independent research group leader.

Keywords: copper,chelator,coordination,peptide,nanoparticle,alzheimer,multitarget
Tick-Virus Interactions Shape persistence and Transmission OF Flavivirus pathogen in tick vector (TVISTOFF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovakia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 155364.48
EU funding (EUR): 155364.48
Participants: 1
Project status: SIGNED

In Europe, tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis, the most important viral life-threatening disease transmitted by ticks. Interactions among the virus, tick and host are inseparable and paramount for a successful circulation of TBEV in an enzootic cycle. Nevertheless, research in this area has predominantly focused on TBEV pathogenesis in vertebrate hosts. Limited knowledge on virus-tick interactions points out to lack of systematic studies and warrants research implementing novel virus-tick models. Therefore, the goal of this fellowship is to investigate the roles of molecular factors of TBEV virulence and tick neurosecretory compounds in adaptation and transmission of TBEV. The innovative concept involves a development of fluorescently labelled TBEV mutants by reverse genetics, implementation of host-free artificial membrane tick feeding system, and characterising components of tick neuroendocrine systems. The interdisciplinary approach of interconnecting the applicant's unique skills in tick physiology and bacterial tick-borne pathogens, expertise of the host group in arbovirology and capacity of partner group in physiology of tick neuroendocrine systems will be instrumental in widening knowledge on virus-tick interactions. Developed tools and obtained results will provide invaluable foundation for research of other neglected tick-borne viruses. Taking together, this fellowship will enable the applicant to reintegrate into the host organisation in his home country, to carry out innovative research, and ultimately to reach professional maturity as an independent investigator.

Keywords: tick borne encephalitis virus,ticks,pathogen transmission,reverse genetics,reporter virus mutants,in vitro tick feeding,neuroendocrinology,neuropeptides,biogenic amines,receptors