Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models. (AMNIOGEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Portugal
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-09-01
End date: 2022-10-31
Duration (months): 26.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative, highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. In particular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery, increasing our understanding of the mechanisms behind bone cancer. The proposed cutting-edge technology enables the culture of human cells in a physiologically relevant microenvironment for applications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement of animal testing and therapeutic applications. The potential of this technology to reduce or completely replace use of animals for biological screenings is expected to have a significant impact in the 3D cell culture market and pharmaceutical industry by accelerating drug screening and development reducing associated costs. The innovation potential of our products is based on the fact that contain human biochemical cues (vital for cell function), is a complete xeno-free solution (avoids contamination) for human cell culture and easy to manipulate. It is worth mentioning that offers the possibility to be personalised (using the patient’s own ECM) according to the customer needs. Moreover, our culture substrates are easily processed in multiple geometries and in microarrays amenable to ‘organ-on- a-chip’ systems designed for high-throughput screening (HTS) applications.

Keywords: 3d cell culture,hydrogels,personalized medicine,disease model,osteosarcoma
ACHIEVING EXCELLENCE IN TRAVEL EXPERIENCE THROUGH PERSONALISED, REAL-TIME COMMUNICATION WITH MASS AUDIENCES. (BizTweet)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Ireland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Communicating time-sensitive changes efficiently to passengers is a major challenge faced by the aviation industry on a daily basis. In recent years, trends show that the market shifted to using social media to seek customer support, but are airports and airlines equipped to handle the barrage of requests received daily? And the numbers are always growing as more and more passengers turn to social media for support! Offering customer support via social media brings with it a promise of efficiency and immediacy, but with limited available resources, can these businesses afford to invest in so much manpower to answer all customer queries within minutes of receiving them? Apparently not, as current data shows that some of the reputed best companies in the aviation industry, such as American Airlines, British airways, can handle at maximum 57% of incoming queries, (Emirates manages to successfully interact with 27.34% of customers). Not a bad result at face value, but when thinking of the majority of the passengers that get their queries ignored, it is easy to understand why the airport experience causes most anxiety and is the part of the journey most passengers do not look forward to. BizTweet, builds upon the proven powers of social media. The platform aggregates and analyses records about passengers, flight details and information from the surrounding environment to provide personalised and relevant data to each individual traveller. BizTweet, also enhances brand image and reputation of airports and promotes non-aeronautical revenue generation through tailored advertising. The platform offers seamless and personalised experience to millions of passengers passing through airports, while generating increased revenue from an aeronautical and non-aeronautical perspective.

Keywords: communication,personalised information,real time,travel experience,peace of mind,revenue generation
Digital Wellbeing in a Culture of Ubiquitous Connectivity: Towards a Dynamic Pathway Model (DISCONNECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1499860.0
EU funding (EUR): 1499860.0
Participants: 1
Project status: SIGNED

Ubiquitous connectivity increases our autonomy: We can connect to content, contacts and services without time or place constraints. Paradoxically, however, ubiquitous connectivity also threatens that very autonomy: The addictive design of digital technologies diverts attention away from our primary activities, and in our contemporary culture of connectivity we face increasing pressures to be permanently online and permanently connected. This mobile connectivity paradox presents an urgent challenge: How can we balance connectivity and disconnectivity so that we experience digital wellbeing? Current scholarship lacks answers to this question. It fails to account for the dynamic nature of digital wellbeing and to sufficiently address the interplay between psychological, technological and social factors. This research project overcomes these limitations by building a dynamic pathway model of digital wellbeing. The model is tested via a multi-method and multi-paradigmatic empirical approach that integrates traditional data sources with behavioral data gathered via device logging and dynamic data on users’ momentary states and contexts gathered via mobile experience sampling. Data are analyzed using innovative digital ethnographic and machine learning methods. This empirical test of the dynamic pathway model of digital wellbeing gives insight into (1) how individuals understand and practice digital wellbeing, (2) which constellations of person-, device- and context-specific factors form pathways that lead to short-term changes in digital wellbeing and long-term changes in indicators of overall wellbeing such as burnout or depression, and (3) what impact digital wellbeing interventions have on digital wellbeing. Armed with these insights, stakeholders such as users, technology developers and policy makers can take steps to increase digital wellbeing.

Keywords: digital wellbeing,digital media use,wellbeing,computational social sciences,digital ethnography
Eroding Democracies. A qualitative (re-)appraisal of how policies shape democratic linkages in Western democracies (QUALIDEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1491658.75
EU funding (EUR): 1491658.75
Participants: 1
Project status: CLOSED

The future consolidation or erosion of western democracies depends on the political perceptions, experiences and participation of ordinary citizens. Even when they disagree on the implications of their findings, previous studies stress that both attitudinal and behavioural forms of democratic linkages – political trust, political support, loyalty, formal and informal participation – have come under considerable pressure in recent decades. The QUALIDEM project offers a qualitative (re)appraisal of citizens’ (dis-)affection towards politics by relying on the core argument of the policy feedback literature: attitudes and behaviours are outcomes of past policy. It aims to explain the evolutions of democratic linkages as being shaped by public policy, and specifically by the turn to neoliberalism and supranationalisation. It aims to systematically analyse the domestic and socially differentiated effects of both of these major macro transformations to citizens’ representations and experiences of politics, as an addition to the existing emphasis on individual determinants and the existing contextual explanations of disengagement and disaffection towards politics. On the theoretical level, this project therefore aims to build bridges between scholars of public policy and students of mass politics. On the empirical level, QUALIDEM relies on the reanalysis of qualitative data – interviews and focus groups – from a diachronic and comparative perspective focusing on four Western European countries (Belgium, France, Germany and the UK) with the US serving as a counterpoint. It will renew the methodological approach to the question of ordinary citizens’ disengagement and disaffection by providing a detailed and empirically-grounded understanding of the mechanisms of production and change in democratic linkages. It will develop an innovative methodological infrastructure for the storage of and access to twenty years of qualitative European comparative surveys.

Keywords: citizens attitudes towards politics,participation,citizenship,policy feedback,western democracies,comparative policy analysis,reanalysis of qualitative data interviews,focus groups
Gap Analysis for Integrated Atmospheric ECV CLImate Monitoring (GAIA-CLIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Estonia,Ireland,Italy,Germany,Germany,Italy,Germany,Finland,Belgium,Norway,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Observation capacity mapping in the context of Atmospheric and Climate change monitoring (H2020-EO-2014, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 5999726.25
EU funding (EUR): 5999726.25
Participants: 20
Project status: CLOSED

There is a recognised need for establishing sound methods for the characterisation of satellite-based Earth Observation (EO) data by surface-based and sub-orbital measurement platforms - spanning Atmosphere, Ocean and Land observations and the entire radiance spectrum. Robust EO instrument characterisation is about significantly more than simply where and when a given set of EO and ground-based / sub-orbital measurements is taken. It requires, in addition, quantified uncertainty estimation for the reference measurements and an understanding of additional uncertainties that accrue through mismatches in sampling location and time and the distinct measurement footprints to enable a complete mapping of the reference measurements onto EO measurements. It also needs user tools which include statistical tools and the integrating capabilities afforded by data assimilation systems to enable users to access and work with the data in a ‘virtual observatory’ setting. It is only if robust uncertainty estimates are placed on the ground-based and sub-orbital data and used in the analysis that unambiguous interpretation of EO sensor performance can occur.

Keywords: defining measurement properties,mapping of observational capabilities,metrological traceability,virtual observatory,visualization,user engagement,ecvs,gap analysis
Novel Productivity Enhancement Concept for a Sustainable Utilization of a Geothermal Resource (SURE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Iceland,Germany,Lithuania,Lithuania,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2015-1-two-stage, 2015)
Start date: 2016-03-01
End date: 2019-08-31
Duration (months): 42.0
Total project cost (EUR): 6143415.0
EU funding (EUR): 5892165.0
Participants: 10
Project status: CLOSED

Within the project SURE (Novel Productivity Enhancement Concept for a Sustainable Utilization of a Geothermal Resource) the radial water jet drilling (RJD) technology will be investigated and tested as a method to increase inflow into insufficiently producing geothermal wells. Radial water jet drilling uses the power of a focused jet of fluids, applied to a rock through a coil inserted in an existing well. This technology is likely to provide much better control of the enhanced flow paths around a geothermal well and does not involve the amount of fluid as conventional hydraulic fracturing, reducing the risk of induced seismicity considerably. RJD shall be applied to access and connect high permeable zones within geothermal reservoirs to the main well with a higher degree of control compared to conventional stimulation technologies. A characterization of the parameters controlling the jet-ability of different rock formations, however, has not been performed for the equipment applied so far. SURE will investigate the technology for deep geothermal reservoir rocks at different geological settings such as deep sedimentary basins or magmatic regions at the micro-, meso- and macro-scale. Laboratory tests will include the determination of parameters such as elastic constants, permeability and cohesion of the rocks as well as jetting experiments into large samples in. Samples will be investigated in 3D with micro CT scanners and with standard microscopy approaches. In addition, advanced modelling will help understand the actual mechanism leading to the rock destruction at the tip of the water jet. Last but not least, experimental and modelling results will be validated by controlled experiments in a quarry (mesoscale) which allows precise monitoring of the process, and in two different geothermal wells. The consortium includes the only company in Europe offering the radial drilling service.

Keywords: renewable heating and cooling,water jet drilling,coiled tubing
Development of a high-resolution method to monitor structural changes of regulatory RNAs and therapeutic oligo-nucleotides directly in-cell. (RNAatHD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

MicroRNAs (miRNAs) are master regulators in cells with a complexity yet to be unraveled. By targeting one or more messenger RNAs (mRNAs) they affect a vast number of biological processes and are associated with a broad spectrum of diseases, including cancer. This makes them potential candidates for cancer-diagnostics and -therapeutics. This opportunity can only be fully exploited by a better comprehension of how and when each mRNA is targeted by a miRNA, a fact, which is currently still poorly understood. Besides regulatory RNAs, synthetic “anti-sense” oligonucleotides (AONs) are currently tested as cancer drugs. Progress in this field has been slow due to unspecific off-target-effects i.e. the lack of understanding, of the mechanism of AONs targeting mRNAs. This project focuses on overcoming this lack of knowledge of the targeting process. To understand the intermolecular interactions occurring in the cell we will, for the first time, monitor the molecular structure and structural changes (dynamics) of nucleotides (miRNAs as well as AONs) in the living cell, and link these in-cell structures to the molecule’s targeting function. Combining existing knowledge of the host in structural and molecular biology of miRNAs with the experience in methods development in Nuclear Magnetic Resonance (NMR) of the experienced researcher (ER), we will develop a set of robust and reliable in-cell NMR methods to determine cellular concentration, structure and dynamics within the cell at high resolution. The scope of the method will be demonstrated on: (i) a miRNA, miR-34a, which targets more than 50 different mRNAs, related to cancer and other cellular processes, as well as (ii) an AON drug candidate in collaboration with AstraZeneca. This project will benefit drug development against various diseases and will enable the ER to contribute to solving today's health problems and develop further towards becoming a future group leader on the interface of research in academia and industry.

Keywords: in cell nmr,structure,dynamics,mirna,mir34a,drug development,cancer
Roots in armour - a barrier induced to protect against intrusion of soil phytotoxins? (ROLLBAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

ROLLBAR focuses on the role of two contrasting strategies against sulfide toxicity of saltmarsh plant species: i) root radial oxygen loss (ROL) and ii) formation of a root barrier to ROL. Plants inhabiting tidal environments with frequent floods possess internal gas-filled spaces in their tissues (aerenchyma), facilitating oxygen (O2) diffusion from shoot to roots. This trait enables tolerance to the inherently low O2 availability in flooded soils. Such soils show high levels of reduced compounds harmful for plants, amongst which sulfide is a potent phytotoxin. The role of ROL and a root ROL barrier in flood tolerance is widely recognised whereas the function of these traits in protecting roots from phytotoxin intrusion in plant tissues is still controversial. The ROLLBAR project aims to shed light on this topic. O2 escapes from roots via ROL and oxidises the rhizosphere; sulfides are chemically oxidised to sulfate and reduced iron [Fe(II)] is oxidised to Fe(III), which can precipitate on root surfaces as iron minerals called iron plaques. Both ROL and iron plaques can protect plants from sulfide intrusion. When the root ROL barrier (suberin depositions in the outer cell layer) is developed, oxidation of sulfides occurs inside roots, as a result of the better O2 status further enhanced by photosynthesis in light. The ROL barrier could impede sulfide intrusion acting as a shield, although there is no experimental evidence to support this function. The project aims to address three major scientific questions: i) which chemical compounds trigger the formation of a root barrier to ROL? ii) can the ROL barrier prevent sulfide intrusion into roots? and iii) can ROL and iron plaques reduce sulfide intrusion into roots? The novelty of the project relies on obtaining direct measurements of O2 and sulfides at the root-rhizosphere interface of key species using advanced contemporary technology such as microsensors, root-sleeving electrodes and planar optodes.

Keywords: fe2,flooding,iron deposits,phytotoxins,radial oxygen loss,sulfide exclusion,sulfide intrusion,tidal submergence,waterlogging
TAnk HYdrogen Automotive (TAHYA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Belgium,France,France
Call: Improvement of compressed storage systems in the perspective of high volume automotive application (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 3996943.75
EU funding (EUR): 3996943.75
Participants: 9
Project status: CLOSED

While automakers have demonstrated progress with prototypes and commercial vehicles traveling greater than 500 km on a single fill, this driving range must be achievable across different vehicle makes and models and without compromising customer expectations of space, performance, safety, or cost. The TAHYA project, mainly led by industrial partners -already involved in producing and manufacturing hydrogen solutions for the automotive and aviation industry-, will focus on the development of a complete, competitive and innovative European H2 storage system (a cylinder with a mounted On-Tank-Valve with all integrated functionalities) for automotive applications up-performing the actual Asian and US ones. The TAHYA consortium composed of Optimum CPV, Anleg, Raigi, Volkswagen, Chemnitz University of Technology, Bundesanstalt für Materialforschung und -prüfung, PolarixParner and Absiskey will ensure that the development phase of the storage system remain in line with the expectations (cost, performance and safety) required by the market, end users’ and car manufacturers. The key objectives of the TAHYA project are: OBJ#1: Preparatory work to provide a compatible H2 storage system with high performances, safe and Health Safety Environment responsible. OBJ#2: Provide a compatible H2 storage system with mass production and cost competitive. OBJ#3: Regulation Codes and Standards (RCS) activities to propose updates on GRT13 and EC79 according to tests results obtained over the duration of the project.

Keywords: compressed,hydrogen,storage,fcev,fuel cell electric vehicle,fire,safety,optimised,innovative,design,manufacturing,costs,integration capability,standardised,components,automotive