Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoscale Chemical Reactions Studied with In-Situ Transmission Electron Microscopy (NANO-INSITU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: CLOSED

Great successes have been achieved in nanoscience where the development of functional properties and the assembly of nanostructures into nanomaterials have become increasingly important. In general, both the tuning of the chemical and physical properties and the self-assembly of nanocrystals into 2D or 3D superstructures take place in a liquid environment. When analysing the structural properties of nanocrystals using Transmission Electron Microscopy (TEM), this liquid environment is contained between membranes to keep it in the high vacuum. At present, the thickness of the liquid is not controlled, which renders standard imaging at atomic resolution impossible. Here I propose to integrate micro-electromechanical actuator functionalities in the Liquid Cell chips to overcome this problem so that real-time atomic resolution imaging and chemical analysis on nanoparticles in solution becomes a reality. This new in-situ technology will elucidate what really happens during chemical reactions, and will thereby enable the development of new nanomaterials for optoelectronics, lighting, and catalysis. Oriented attachment processes and self-assembly of nanoparticles, which are key to the large-scale production of 2D and 3D nanomaterials, can also be followed in the Liquid Cell. Furthermore, the hydration of nanoscale model systems of earth materials such as magnesia, alumina, and calcium oxide is of major importance in the geosciences. In the field of enhanced oil recovery, for example, the huge volumetric expansion that comes with the hydration of these minerals could facilitate access to reservoirs. My research group has extensive experience in in-situ TEM and recently has achieved significant successes in Liquid Cell studies. We are in an ideal position to develop this new technology and open up these new research areas, which will have a major impact on science, industry, and society.
CK2-dependent cytoskeletal regulation and molecular signaling of Neutrophil Extracellular Trap (NET) formation (COAGULANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Platelets play an essential role in hemostasis but are also critically involved in acute arterial thrombotic occlusions leading to myocardial infarction or ischemic stroke and associated tissue fibrosis which are still the major cause of morbidity and disability in the European Union thus causing enormous costs in the health care system. In the last years there is increasing evidence that primary hemostasis and inflammatory atherothrombosis are crucially affected by leukocytes. Thereby the neutrophils represent the most abundant type of immune celly as almost 50% of all leukocytes belong to the neutrophil subset. The neutrophil extracellular trap (NET) formation is mainly know as pro-thrombotic factor in arterial thrombosis and is characterized by release of decondensed chromatin with incorporated histones and neutrophil elastases after neutrophil activation. Beside their pro-thrombotic effect, NETs were also recently described as inducer of tissue fibrosis in vivo thus contributing to cardiac tissue damage. Although tubulin and intermediate filament rearrangements in the cytoskeleton and nuclear envelope are a prerequisite for NET formation and chromatin release, nothing is know about the underlying molecular mechanisms and targets hitherto. Tubulin dynamics and microtubules are known regulators of intermediate filaments in the nuclear envelope thus maintaining the nuclear integrity of cells. Thereby, the ubiquitous Casein kinase 2 (CK2) is an acknowledged upstream molecule of microtubule dynamics and stability in a wide variety of cells. For this reason, the role of the CK2 in microtubule and intermediate filament dynamics during NET formation and its impact on thrombo-occlusive tissue fibrosis in cardiovascular diseases will be investigated resulting in the identification of new molecular structures suitable for improved and personalized treatment of thrombo-occlusive events like myocardial infarction and ischemic stroke.

Keywords: netosis,casein kinase 2,microtubules,intermediate filaments,tissue fibrosis
PRE-SCREENINGDEVICE FOR SLEEP APNEA (PREDESA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Finland
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Obstructive sleep apnea (OSA) is a common disease, affecting 2–7% of population, but many of them are still undiagnosed. Nukute has developed a novel and cost effective technology to pre-screen and assist in treatment of OSA patients. Innovation utilizes noise (respiratory rate and profile) and acceleration of chest and diaphragm (respiratory motion) first time as biomarkers of OSA. In the pre-screening device a stereo microphone measures the ambient and respiratory sounds, and an accelerometer measures the motion of neck muscles. In addition to these components, the diagnostic device has also two more accelerators and a blood oxygen level measurement. In both cases, the data is wirelessly sent to the mobile phone application. If the device includes the treatment feature, an electrical stimulation prompts the user to adjust sleeping position for increased airflow, when apnea occurs. The first prototype of the device achieved a proof of the concept in the preclinical tests in the beginning of 2015 and the results were very good. The main benefits of this system compared to existing pre-screening and diagnostic devices are easiness to use, cheapness (70-90% cheaper than competitors), accuracy and comfort wireless design. The device has two main product lines: OSA diagnostic and treatment assistance device for professional use and OSA pre-screening and treatment assistance device for consumers. In a first stage, the target market of diagnostic device is Finnish hospitals and that of pre-screening device is consumers in the US. The device has potential to generate big societal savings in Europe and worldwide by offering cost-effective and easy way to pre-screen OSA. The main activities of this project are: creation of patent family in the US, creation of quality management system and application of CE marking, and preparation of US market entry combined with business plan updating.

Keywords: nukute pre screening device enables possibility to measure and identify larger number of patients than ever before more cost effectively and reliably
Architecture for Scalable, Self-*, human-centric, Intelligent, Secure, and Tactile next generation IoT (ASSIST-IoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Malta,Finland,Poland,Greece,Greece,France,Netherlands
Call: Next Generation Internet of Things (H2020-ICT-2020-1, 2020)
Start date: 2020-11-01
End date: 2024-03-31
Duration (months): 41.0
Total project cost (EUR): 7905146.25
EU funding (EUR): 7905146.25
Participants: 17
Project status: SIGNED

ASSIST-IoT will provide an innovative reference architecture, envisioned as a decentralized ecosystem, where intelligence is distributed among nodes by implementing AI/ML close to data generation and actuation, and hyperconnecting nodes, in the edge-cloud continuum, over softwarized smart network. Smart network will be realised by means of virtualized functions, with clear separation of control and data planes, facilitating efficient infrastructure programmability. Moreover, the action will follow a DevSecOps methodology to ensure the integration of security, privacy, and trust, by design, in all aspects of the envisioned ecosystems. ASSIST-IoT will be supported by several pillars: (i) innovative IoT architecture, to adapt to the NGI paradigm, with three-dimensional approach, including intelligence, security and privacy by design, supporting decentralized collaborative decision-making; (ii) moving from semantic interoperability to semantically-enabled cross-platform, cross-domain data transactions, within decentralized governance, DLT-anchoring transaction security, privacy and trust; (iii) development and integration of innovative devices, supporting context-aware computing, to enable effective decision making close to events; (iv) introduction of self-* mechanisms, supporting self-awareness and (semi-)autonomous behaviours across IoT deployments, and (v) Tactile Internet support for latency applications, like AR/VR/MR, and human-centric interaction with IoT components. Results of the action will provide foundation for a comprehensive practice-based methodology, for future designers and implementers of smart IoT ecosystems. Finally, to validate research results, and developed solutions, and to ensure their wide applicability, extended pilot deployments with strong end-user participation will take place in: (i) port automation; (ii) smart safety of workers, and (iii) cohesive vehicle monitoring and diagnostics, bringing about domain-agnostic aspect of the approach.

Keywords: tactile internet of things,next generation architecture,self,decentralized federated intelligence,context awareness,edge analytics,edge computing
FlAgship demonstration of industrial scale production of nutrient Resources from Mealworms to develop a bioeconomY New Generation (FARMYNG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Spain,Italy,Germany,Poland,Norway,Belgium,Switzerland,Hungary,France,France,France,France,France,France,France,France,France,France,Netherlands
Call: Large-scale production of proteins for food and feed applications from alternative, sustainable sources (H2020-BBI-JTI-2018, 2018)
Start date: 2019-06-01
End date: 2024-06-30
Duration (months): 61.0
Total project cost (EUR): 47294008.98
EU funding (EUR): 19630411.18
Participants: 28
Project status: SIGNED

The world faces a major challenge with the sharp increase in demand for meat and fish by 2050, to which current modes of production, whether through agriculture, aquaculture or fisheries, cannot be sustained. An innovative solution to this predicted shortage of resources, especially protein, lies in insect production and processing which can provide a serious response, but to date no industrial scale of production of insect-derived products has been reached. The FARMYNG project has this ambition to develop on an industrial and automated scale the breeding and transformation of insects for the production of animal nutrition, with the strong participation of 20 key actors all along the value chain from the feedstock supply to the final insect transformation. FARMYNG will demonstrate a large-scale, first-of-its-kind bio-based value chain producing sustainable, safe and premium feed products from an innovative origin: the Tenebrio molitor insect (mealworm). The plant developed for FARMYNG will use the efficiency of mealworm physiology to convert vegetal by-products in mealworm biomass and transform those mealworms into sustainable proteins and lipids for fish feed and pet food end markets. In parallel, manure will be recovered for soil fertilization applications. Insects are indeed very effective at converting organic matter. Fed with no-noble materials, insects multiply quickly, and are a rich and natural source of food for certain livestock and pet animals, and probably ultimately for the Humans directly. Insects also emit less greenhouse gases and ammonia and use less water and land than other animal proteins value chains. FARMYNG project, responding to the increasing worldwide proteins demand, will transfer the technology from a demo plant to the Industrial Flagship Plant able to produce almost 1 500 tons of proteins and 400 tons of oil per month, reaching a productions rate never demonstrated before for insect’s proteins production plant.

Keywords: proteins,insects,fish feed,pet food,breeding strategy,extrusion,automated storage,robotic islands
Mechanobiological optimization of regeneration in cell-enriched construct implants within degenerative Cartilages: a defect Repair method through restoring Energy AbsorpTION (CREATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Knee cartilage defects and consequent degeneration contribute to the development of osteoarthritis (OA). OA affects the mechanical integrity of the tissue, whose main function is to absorb shock and minimize peak loads in the underlying subchondral bone. Tissue engineering methods propose solutions to OA by implanting chondrocyte cell-enriched hydrogel/scaffold constructs within degenerative cartilage defects. By applying mechanical loads to stimulate the cells within the constructs, they initiate cartilage extracellular matrix (ECM) synthesis. The mechanical environment of the cell-seeded construct has a crucial role in defining the quality and quantity of the regenerated ECM. This will determine the mechanical performance of the cartilage tissue. Indeed, any repair method has to aim at restoring the unique cartilage mechanics, in particular, the energy absorption capacity. This project aims at restoring energy absorption of degenerative cartilage by optimizing regeneration in cell-enriched construct implants. The goal will be pursued by developing an in-silico framework for mechanobiological modelling of the regeneration and degeneration in the cartilage-implant compound during loading. Unique in the in-silico framework is the simultaneous modelling of regenerative and degenerative processes through adaptive modelling of the ECM. An innovative regeneration algorithm will be developed and integrated with a previously developed degeneration model. The adaptive model will then be used in an optimization scheme to minimize differences between energy absorption of construct implant and native human cartilage. An iterative performance evaluation is foreseen in comparison with biological experiments. In collaboration with the participating research groups and using my background, I will have a unique chance to take a step forward in furthering insights on OA disease process. The anticipated collaborations and training will contribute to making me a mature researcher.

Keywords: articular cartilage,mechanobiological modelling,degeneration,regeneration,finite element analysis,adaptive modelling,construct implants,osteoarthritis joint,energy absorption,cartilage repair
Visiting the Margins. INnovative CULtural ToUrisM in European peripheries (INCULTUM)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Innovation actions
Countries involved: Italy,Italy,Albania,Spain,Albania,Ireland,Slovakia,Sweden,Greece,France,Denmark,Denmark,Portugal
Call: Innovative approaches to urban and regional development through cultural tourism (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 3752131.25
EU funding (EUR): 3487411.25
Participants: 15
Project status: SIGNED

Tourism is more than travelling and consumption; it has great potential when it comes to culture, nature, knowledge and personal experiences. Travelling is a way to learn and improve oneself, to enrich one’s vision and improve mutual understanding. The INCULTUM project deals with the challenges and opportunities of cultural tourism with the aim of furthering sustainable social, cultural and economic development. It will explore the full potential of marginal and peripheral areas when managed by local communities and stakeholders. Innovative participatory approaches will be adopted, transforming locals into protagonists, able to reduce negative impacts, learning from and improving good practices to be replicated and translated into strategies and policies. Furthermore, INCULTUM fosters intercultural understanding through the implementation of bottom-up strategies that can have positive effects for both, locals and tourists. Ten pilot cases of living territories and communities will be investigated and on the basis of the findings innovative customised solutions will be co-created. Additionally, pilots will be used to identify and compare drivers and barriers that account for the success or failure of participatory models. Pilots will also enable us to assess outcomes and analyse the pre-conditions needed for a future full implementation and scaling up of potential solutions. Pilots will provide new quantitative and qualitative data that will be combined with official statistics and novel data gathered by the use of self-developed IT applications and the exploitation of previously untapped data sources. The implementation of advanced econometric methods and the pioneering introduction of machine-learning tools into tourism research will push the boundaries of our knowledge. Findings will enable us to suggest recommendations for effective and sustainable policies, create new synergies among public and private stakeholders and new investments, including Structural Funds

Keywords: cultural tourism,sustainable development,intercultural understanding,cooperation,participatory approach,peripheral areas,marginal cultural heritage,natural heritage,local production,policies
From Measurements to Standardized Multi-Domain Compact Models of LEDs (DELPHI4LED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Ireland,Hungary,Belgium,Finland,Switzerland,Finland,France,France,France,Netherlands
Call: Design Technology (H2020-ECSEL-2015-1-RIA-two-stage, 2015)
Start date: 2016-06-01
End date: 2019-09-30
Duration (months): 40.0
Total project cost (EUR): 8922406.0
EU funding (EUR): 2679293.26
Participants: 15
Project status: CLOSED

The European lighting industry aims at reducing cost, at continuously improving product performance while reducing time to market and enlarging the product. The main challenge for the design in of LED components into lighting systems is the temperature and current dependence of their performance. In order to achieve a good design of LED systems, a modular, multi-physics based modelling approach is needed – this way allowing the freedom for LED component integrators to use such models in any kind of luminaire designs. In order to overcome those key challenges, seamless integration of the LED in the product development chain is necessary. For that a bridge, in the form of standardization, has to be established between the semiconductor industry and the LED component integrators. In order to achieve this, the following tools have to be provided: • Generic, multi-domain model of LED chips • Compact thermal model of the LED chips’ environment • Modeling interface towards the luminaire The goal of the project is to develop a standardized method to create multi-domain LED compact models from testing data. The objectives are: • Define set of LED model equations that can be implemented into a FEM/CFD tool, for the purpose of self-consistent multi-domain simulation of LEDs thermal, electrical and light output characteristics. • Provide interfacing between measurement tools, modelling tools and simulation tools to allow the application of the compact LED models. • Prove the benefits of the use of compact models in the development process to reduce development times and cost. This will lead to an industry standard in the lighting industry. Achievement of this project is expected to boost time to market of LED products cut by 1/3, cut development cost by 50%, reduce Cost of Non-quality by 25%. The European lighting industry is offered a unique competitive advantage, necessary to catch the 30-40% speed of growth of its LED market and tape into potential new markets.

Keywords: multi physics modelling,compact models