Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the Impact of Narratives and Perceptions of Europe on Migration and Providing Practices, Tools and Guides for Practitioners (PERCEPTIONS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Italy,Egypt,Israel,Austria,Italy,Algeria,Germany,Cyprus,Belgium,Bulgaria,Greece,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Kosovo
Call: Human factors, and social, societal, and organisational aspects of border and external security (H2020-SU-SEC-2018, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 4994652.5
EU funding (EUR): 4994652.5
Participants: 26
Project status: CLOSED

Narratives of a “better life” that can become reality elsewhere have always been shaping human migration. The image or idea of a “promised land”, however, might not be real, and newcomers are often faced with obstacles and challenges. Certain narratives and perceptions of Europe influence migration aspirations and false images can not only lead to problems when the image does not hold true, but it might also even lead to security threats or risks to migrants. It is, therefore, of the utmost importance to understand and investigate narratives about Europe, how these can lead to problems and threats, how they are distributed, and, in the next step, find ways to react and counteract them. Perceptions of Europe are formed in the country of residence, and they are based on a multitude of sources. Social media and new communication networks, in addition, have increased the scope and the intensity of distribution of such narratives; furthermore, so-called filter bubbles and echo chambers can lead to isolated misperceptions that are not corrected. Due to new communication technologies, false or incorrect claims become life on their own, raising expectations or disapproval. At the same time, however, these technologies and communication networks might also provide a channel to set an exaggerated image straight and promote a more realistic narrative. It is, therefore, the aim of the PERCEPTIONS project to identify and understand the narratives and perceptions of the EU abroad, assess potential issues related to the border and external security in order to allow better planning and outline reactions and countermeasures. For that purpose, the project will conduct research on the narratives and the myths that are circulating about the EU in countries West- and Central Mediterranean areas. Based on the research insights, the consortium will develop a PERCEPTIONS framework model including policy recommendations and action plans.

Keywords: perceptions,narratives,social media,migration
Coordination Of Patterning And Growth In The Spinal Cord (GROWTHPATTERN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 1499119.0
EU funding (EUR): 1499119.0
Participants: 1
Project status: CLOSED

Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve this reproducibility is a fundamental question in biology. Yet, surprisingly little is known about the underlying mechanisms. A major challenge has been to obtain the quantitative data required to assess the dynamics and variability in growth, pattern and signalling by morphogens – molecules that regulate both cell fate specification and tissue growth. I recently established experimental and theoretical approaches that allowed me to reconstruct with unprecedented resolution the three-dimensional growth and pattern of mouse and chick spinal cord. My data revealed a previously unanticipated role of tissue growth dynamics in controlling pattern reproducibility. This quantitative framework provides an exciting opportunity to elucidate the biophysical and molecular mechanisms of growth and pattern coordination. I will use this unique position to understand: 1) how signalling by multiple morphogens is integrated to control pattern, 2) how morphogens control cell cycle kinetics, 3) how morphogen source and target tissue are coupled to achieve pattern reproducibility. To address these issues, I will build on my experience with quantitative analyses to design novel assays where signalling, cell cycle dynamics and transcriptomes can be precisely measured and manipulated with single cell resolution. I will exploit state-of-the-art genome editing techniques to uncouple the critical feedback links and gain a novel perspective on pattern reproducibility and morphogen function. The project will advance our fundamental understanding of tissue morphogenesis and provide novel insights relevant to understanding information processing by signal transduction cascades, morphogen gradient activity, tissue engineering, and cancer biology.
Revealing the Epigenetic Regulatory Network with Single-Molecule Precision (SM-Epigen)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Genes and genomic elements are packaged by chromatin structures that regulate their activity. The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones. The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes. However, the field lacks technologies for detection and analysis of such combinations, thus impeding our ability to test this hypothesis and shed light on human genome regulation. Our recent proof-of-principle for a single-molecule system for mapping combinatorial chromatin modifications holds the technological solution. This powerful method can identify directly unique combinations of epigenetic marks and reveal regulatory modules that can only be ascertained by single-molecule studies. The proposed project will scale-up and advance our technology to establish robust high-throughput systems for investigating combinatorial chromatin and TF interactions and identify their genomic locations, thus bridging the gap between single-molecule proteomics and genomics. We will apply it to address basic questions in epigenetic regulation during early development, and define the network of interactions between histone marks, DNA methylation and the core TFs in stem cells and differentiated cells. We will also harness our technology to reveal the tissue-of-origin of cell-free DNA circulating in our blood in the form of nucleosomes, and apply it to devise novel strategies for early detection of cancer and other diseases. Successful implementation and dissemination of these novel systems will yield a transformative new technology for functional genomics that will unravel the chromatin language during early development. This work will open new research directions at the interface of genomics and proteomics, and pave the way for the development of therapeutic and diagnostic tools.

Keywords: functional genomics
South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1993378.0
EU funding (EUR): 1993378.0
Participants: 1
Project status: SIGNED

The central challenge faced by linguistics is to understand linguistic diversity. Despite influential programmatic studies and sustained interest, many aspects of the evolution of linguistic diversity remain elusive. Yet, the potential value of understanding linguistic diversity is enormous. It could help us uncover specific past events such as migration and historical contact between societies, perhaps even in very deep time and, more generally, it can give us insight into the interaction between ecology and human behaviour and human cognition. This project will answer these challenges by focussing on the Upper Amazon in western South America, an area which forms a unique microcosm of diversity in which several sociohistorical layers of the continental population history are represented. The north and south are extremely diverse, and likely represent very old diversity patterns. Both areas also show signs of local language contact. The central part is dominated by three language families, which represent expansions of these groups into the Upper Amazon at different stages. This microcosm of diversity forms a unparalleled natural laboratory for understanding more about sociological dynamics and the evolution of linguistic diversity. The project will take an innovative multi-disciplinary approach to unearthing the socio-historical dynamics that have led to these various diversity patterns. In order to do so, geographical, socio-historical, and communicative layers of history are reconstructed and systematically compared, achieving a level of synergy between the disciplines hitherto unseen. Interpreting the (mis)matches between these layers allows for a powerful reconstruction of past events, (e.g. migrations, language shift, exogamy, trade), and sheds light on how these social dynamics shaped linguistic diversity, in turn unlocking the potential of linguistic diversity as a unique window on our past.

Keywords: population history,language contact,multi disciplinarity,south america
Advanced graphene nanodevices with functional hydrogels for DNA sequencing (GRAPHNANOGEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

With this proposal, I propose a new chemical approach inspired by DNA gel electrophoresis to slow down DNA translocation through a graphene nanopore or a nanogap, and to reduce the mechanical fluctuations of the graphene membrane as DNA translocates. Thus far using graphene nanodevices to sequence DNA molecules in real time has been hampered by two major drawbacks: i) the too fast translocation of single DNA molecules through a graphene nanodevice, and ii) the very large low frequency electronic noise presumably due to mechanical vibration of the free-standing graphene membrane in aqueous buffers. Both these phenomena prevent single nucleotide identification (at least compared to biological nanopores). The direct chemical functionalization of graphene film with functional polymeric hydrogels will i) induce electrostatic and chemical affinities between DNA and the functional polymer hydrogel and ii) stabilize mechanically graphene from vibrating. The host group of Dr. Schneider was the first to propose graphene nanopores as single molecule DNA sensors in 2010 and has gained a lot of experience in this field. Dr. Schneider’s group is now approaching DNA sequencing with graphene nanostructures with a strong chemistry component. Schneider’s lab in Leiden is therefore, at the moment, the best place in the world to make this research proposal a success. I do believe this proposal has the potential to lead toward ground-breaking applications in nanopore-based biosensors, particularly for high throughput next generation sequencing applications with graphene nanogaps.

Keywords: graphene,nanopores,nanogaps,dna sequencing
Energy-efficient membranes for carbon capture by crystal engineering of two-dimensional nanoporous materials (UltimateMembranes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 1875000.0
EU funding (EUR): 1875000.0
Participants: 1
Project status: SIGNED

The EU integrated strategic energy technology plan, SET-plan, in its 2016 progress report, has called for urgent measures on the carbon capture, however, the high energy-penalty and environmental issues related to the conventional capture process (amine-based scrubbing) has been a major bottleneck. High-performance membranes can reduce the energy penalty for the capture, are environment-friendly (no chemical is used, no waste is generated), can intensify chemical processes, and can be employed for the capture in a decentralized fashion. However, a technological breakthrough is needed to realize such chemically and thermally stable, high-performance membranes. This project seeks to develop the ultimate high-performance membranes for H2/CO2 (pre-combustion capture), CO2/N2 (post-combustion capture), and CO2/CH4 separations (natural gas sweetening). Based on calculations, these membranes will yield a gigantic gas permeance (1 and 0.1 million GPU for the H2 and the CO2 selective membranes, respectively), 1000 and 10-fold higher than that of the state-of-the-art polymeric and nanoporous membranes, respectively, reducing capital expenditure per unit performance and the needed membrane area. For this, we introduce three novel concepts, combining the top-down and the bottom-up crystal engineering approaches to develop size-selective, chemically and thermally stable, nanoporous two-dimensional membranes. First, exfoliated nanoporous 2d nanosheets will be stitched in-plane to synthesize the truly-2d membranes. Second, metal-organic frameworks will be confined across a nanoporous 2d matrix to prepare a composite 2d membrane. Third, atom-thick graphene films with tunable, uniform and size-selective nanopores will be crystallized using a novel thermodynamic equilibrium between the lattice growth and etching. Overall, the innovative concepts developed here will open up several frontiers on the synthesis of high-performance membranes for a wide-range of separation processes.

Keywords: two dimensional membranes,carbon capture,crystal engineering,gas separation,exfoliation,top down synthesis,bottom up synthesis,metal organic frameworks,graphene,chemical vapor deposition
Circular Construction In Regenerative Cities (CIRCuIT) (CIRCuIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Finland,Finland,Finland,Denmark,United Kingdom,Denmark,United Kingdom,Denmark,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Demonstrating systemic urban development for circular and regenerative cities (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 10579687.5
EU funding (EUR): 9814612.5
Participants: 32
Project status: SIGNED

To this day, many techniques, tools and approaches have been developed and tested either on a lab scale or in pilot buildings around Europe. These demonstrations have served as great showcases for circular built environments, but they are yet to be demonstrated at higher level. Copenhagen, Hamburg, Helsinki region (City of Vantaa) and Greater London have teamed up with partners from the entire built environment value chain. The results will have a direct uptake in the value chain and enable cities to initiate circular transition. CIRCuIT will demonstrate three innovative solutions in the four cities: dismantle buildings to reuse materials; transformation and refurbishment; and design for disassembly and flexible construction. CIRCuIT will develop urban planning instruments to support cities in implementing circular construction solutions and initiate changes at system level; implement a Circularity Hub, a data platform to evaluate progress of circular economy and regenerative capacity; and set up a knowledge sharing structure, the CIRCuIT Academy, to promote upscaling of solutions. London, Hamburg, Helsinki region and Copenhagen have the ambition to bridge the implementation gap from individual pilots to the actual circular and regenerative city, by demonstrating the application of current and future developed tools and instruments for circular built environment at a city level in 36 demonstration projects. It is the intention to boost the regenerative capacity of the three cities and Helsinki region, and finalise the development of an advanced set of indicators for impact measurement in an effective and cross-European monitoring programme. The aim is to increase the regenerative capacity in the four cities, and to reduce the yearly consumption of virgin raw material by 20% in new built environments, and to show cost savings of 15%.

Keywords: circular construction,urban mining,urban planning,refurbishment,design for dissassembly,data platform,circuit academy,co creation,value chain partnership,governance,liveability,transform
Optical Ultrasound Imaging for Real-time Guidance of Intracardiac Procedures (MOPHIMPOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-08-01
End date: 2017-01-31
Duration (months): 18.0
Total project cost (EUR): 149624.0
EU funding (EUR): 149624.0
Participants: 1
Project status: CLOSED

This European Research Council Proof of Concept grant is focused on translating a new medical device for interventional cardiology from a proven laboratory prototype to a commercial prototype. The core innovation in this medical device is a new type of ultrasound imaging probe that can be readily integrated into medical devices to guide minimally invasive procedures. Current generation probes, which are based on electrical methods of ultrasound generation, involve complex fabrication processes that make them prohibitively expensive for many applications. The technology platform underlying the new ultrasound imaging probes includes both optical transmission and reception of ultrasound waves. The new probes are fabricated with inexpensive optical fibres, using simple techniques that are highly scalable for large-volume production. With fabrication costs that are approximately 10 times lower than those of current generation probes, they will address large under-served markets in which current generation probes are too expensive to be reimbursed. They can be readily integrated into small diameter needles and catheters, which make them attractive for a wide range of clinical applications. The commercial prototype that will be developed with this ERC POC grant will address a specific clinical application in the field of Cardiac Electrophysiology. As it will be designed to be manufactured as part of a quality system, it will be compelling for commercialization and for obtaining follow-on funding. The POC grant will be undertaken in close collaboration with Cardiac Electrophysiologists at Barts Hospital, and a medical device consultancy in the UK with expertise in the development of ultrasound imaging probes. Clinician interviews will be conducted at a European clinical congress, and the resulting insights will be included as part of a business plan and pitch presentation to external investors to obtain follow-on funding.

Keywords: medical device,ultrasound,optical fibre,commercial prototype,intracardiac