Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Systematic study of post-transcriptional regulation mediated by RNA-binding proteins and miRNAs (PTRCODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Post-transcriptional regulation (PTR) is increasingly recognized as a pervasive and complex system that regulates every aspect of RNA metabolism including splicing, localization, stability and translation. PTR is mediated by the interactions of trans-factors such as RNA-binding proteins (RBPs) and miRNAs with cis-acting elements located in mRNAs. Regulatory networks controlled by RBPs and miRNAs have been viewed as two distinct mechanisms; however, a number of recent studies have shown that RBPs and miRNAs can act in coordination. Previous studies of PTR have ignored this fact and only focused on a single class of factors, i.e., either RBPs or miRNAs. In this proposal, we will (i) develop computational models that consider the joint effect of multiple RBPs and miRNAs to explain PTR events (ii) integrate our PTR model with additional regulatory elements such as transcription factors, epigenetic marks and copy number changes to explain more general phenomena such as differential gene expression in cancer. Recent explosion of data in (i) RBP binding specificities, (ii) post-transcriptional fate of mRNAs (e.g. localization, stability) and (iii) mRNA-bound proteome in human cells have enabled the systematic study of post-transcriptional events, which is the main goal of this proposal. The proposed project will start with a genome-wide mapping of binding sites of RBPs and miRNAs in mRNAs. These potential binding sites will then be investigated for cooperative or competitive interactions between RBPs and miRNAs. Independent binding sites and interactions will be converted to features, and used in statistical models to identify cis-regulatory elements that are predictive of PTR events such as localization, stability, and differential gene expression in cancer. Identification of such cis-regulatory elements and their interacting trans factors will lead to new insights in disease-causing perturbations, and hence, will hopefully lead to novel approaches for their cure.

Keywords: computational biology,post-transcriptional regulation,rna-binding proteins,micrornas,rna secondary structure,machine learning
Lipid Packing and Protein Crowding in Lipid Droplets and the ER Membrane (PACKNCROWD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cellular compartments are separated by membranes composed of a lipid bilayer with embedded proteins. An exception are lipid droplets (LDs), which consist of a neutral lipid core and a protein-containing phospholipid monolayer. Many cellular reactions occur on organellar surfaces and necessitate changes in their physical organization. This proposal addresses two under-explored questions pertaining to biological proteo-lipid interfaces: i) how a phospholipid monolayer differs from a bilayer in its physicochemical properties, and ii) how the mechanical behavior of a bilayer membrane is affected by its abundant protein component. Adsorption of peripheral proteins to a phospholipid surface often depends on defects in packing of lipid molecules, which enable insertion of amphipathic helices. We propose to explore how packing of phospholipid molecules in a monolayer surrounding an LD differs with respect to a bilayer, enabling recruitment of LD-specific proteins. To address this question, we will use established cell biology approaches and we will develop novel biochemical assays. We will combine our experiments with an in-silico analysis. Proteins represent around two thirds of the total mass of a biological membrane and crowding of proteins in the membrane can have a profound effect on reactions that require membrane deformation. We are in particular interested in how crowding of proteins with an asymmetric distribution of mass across the membrane affects formation of transport vesicles. Using the example of COPII vesicle formation from the ER membrane, we will perform a theoretical and a computational analysis and compare the results with genetic experiments in budding yeast.

Keywords: lipid droplet / endoplasmic reticulum / lipid packing / protein crowding / cellular biology / lipid monolayer / lipid bilayer / reconstitution / molecular dynamics / physics of membrane deformation
The role of ryanodine cluster morphology in arrhythmogenic calcium release after myocardial infarction (CARDIOCLUSTER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Contraction of the heart occurs by the intracellular release of calcium through channels called ryanodine receptors (RyR), after electrical activation. Due to the progression of heart disease, structural and functional remodeling of at the level of the cardiac cell is known to occur. This remodeling process alters the electrical properties of the heart muscle cell and can lead to the production of an irregularity in the electrical activity of the heart called an arrhythmia. Studies have shown a that disruption of the normal behavior of the RyR can lead to the production of arrhythmic events and these have been linked to the occurrence of intracellular waves of propagating calcium release called calcium waves. The precise mechanisms which underlie this process are currently unknown and warrant further investigation. Using a multidisciplinary approach, alterations in RyR cluster structure will be assessed and correlated with alterations in calcium release after remodeling in a rabbit model of myocardial infarction. Using cultured rabbit myocytes, the involvement of a protein called junctophilin-2 in the regulation of the RyR clustering process will also be assessed. The functional consequences of RyR cluster morphological alteration will be assessed, such as phosphyorylation and the efficacy of anti-arrhythmic drugs.

Keywords: heart disease,calcium signaling,super resolution microscopy,arrhythmia
Video-Based Smart Parking System (PARQUERY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-07-01
End date: 2015-06-30
Duration (months): 12.0
Total project cost (EUR): 162100.0
EU funding (EUR): 149490.0
Participants: 1
Project status: CLOSED

In the central business districts of many cities, a large fraction of the traffic comes from cars cruising for parking. One study estimates that as much as 30% of the traffic in downtown areas of major cities. Cruising wastes time and fuel for drivers and is also detrimental to the municipality, as it pollutes, congests traffic and degrades pedestrian environments. Parking search assistance is one of the major unsolved problems in urban mobility. Occupancy information is currently only available in parking garages and off-street parking, where parked cars are easily counted. For on-street parking, which is more preferable to drivers since it is usually cheaper and more convenient, occupancy is not so easily obtained. We are developing a vision-based smart parking system for monitoring on-street parking occupancy. A camera network monitors parking spots throughout the city and sends images to centralized servers, where the images are then processed with computer vision algorithms to determine parking availability. Real-time occupancy information can be broadcast to drivers through a website or phone app, while aggregate statistics can be provided to parking administrators. One can further integrate navigation to nearby parking, payment and enforcement functions directly into the system. Such a smart parking system can greatly reduce frustrations of finding parking and also the noise and pollution from traffic congestion.

Keywords: 290911
A novel high-throughput tool to genotype human genome inversions for personalised medicine (INGENIHUS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-06-01
End date: 2015-05-31
Duration (months): 12.0
Total project cost (EUR): 163238.0
EU funding (EUR): 149670.0
Participants: 1
Project status: CLOSED

The completion of the Human Genome Project has generated a new industry of personal genomics and personalized medicine, which aims to determine the entire DNA sequence of an individual to predict possible disease risks and improve treatment. However, despite the initial high expectations, it has not been possible to find the genetic causes for many common and complex diseases. Most of the work has been focused in one type of genetic variants, the single nucleotide variants or SNPs, but it has been recently shown that there are many other changes affecting larger regions of the genome, known as structural variants. One type of structural variant that has been implicated in functional differences between individuals and genetic diseases are inversions. Nevertheless, they have been poorly studied due to technical difficulties and there is not a global methodology to determine their presence in a quick and easy way. As part of the INVFEST ERC Starting Grant, we have developed a novel high-throughput screening technique for genotyping multiple inversions in hundreds of individuals. This project proposes the generation of a proof of concept package to move forward in the development of an innovative diagnostic kit of human genome inversions to be licensed to an industrial partner for its commercialization. To achieve this, the main goals are: (1) Optimizing the methodology by decreasing the amount of DNA needed and increasing the coverage to most known human inversions, especially those clinically relevant; (2) Strengthen the current patent through a freedom to operate study and a patent cooperation treaty application, and (3) Analyze the market to determine needs in inversion genotyping and compile feedback from the potential licensees and end-user companies. The availability of this technique would be crucial to identify unknown associations between inversions and phenotypic traits, including diseases, thus increasing its value and helping to fulfill genomics promises.

Keywords: 243212
Integrated monitoring and forecasting system for local weather and microclimate (INMOST)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Finland
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-04-01
End date: 2015-03-31
Duration (months): 12.0
Total project cost (EUR): 226458.0
EU funding (EUR): 149530.0
Participants: 1
Project status: CLOSED

The project aims to prove commercial potential of innovative system for monitoring and prediction of usual and chemical weather and microclimate based on: • New concept and models of atmospheric planetary boundary layer (PBL) as natural object responsible for local features of weather and climate • Wireless sensor network technology to perform monitoring of environmental parameters with very high spatial and temporal resolution • Machine learning technology for integrating weather-forecast data and sensor-network monitoring data into super-fine resolution weather forecast or microclimate evaluation • Local GIS and decision-making support (DMS) technologies The basic idea lies in retrieving extreme and local features of weather (or climate) from combination of inexact information from operational weather prediction (or climate) models with local monitoring of PBL-control and customer-specific parameters. Both information flows are digested through machine-learning technology accounting for new knowledge about PBL. The system starts operating with a period of tuning to local features of weather (or climate), which improves its performance and guaranties higher than operational quality of weather forecast (or microclimate evaluation). Commercial potential of the idea will be implemented through establishing a business aimed at: • Production and sales of monitoring/forecast correction systems: advanced versions – to municipalities, hospitals, agricultural, transport and energy companies; simple versions – to collective or individual customers, e.g., local communities, farmers, owners of summer houses • Providing microclimate and land-use consulting, e.g., for construction or precision agriculture • Delivering locally adjusted customer-specific weather forecasts for weather-dependent companies The project implies global economic and societal benefits due to improved forecasting of extreme and dangerous weather events and advanced tools for land use.

Keywords: 227915
Optical Fibre based self-monitoring Motor Drives (OFS-MOTOR)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 798618.0
EU funding (EUR): 598963.0
Participants: 1
Project status: CLOSED

Electrical machines and drives being developed within the Clean Sky programme are adopting novel, power-dense, circuit and electromagnetic topologies working close to the material limits and excited by non-conventional waveforms. This brings about requirements for increased health-monitoring and cooling demands for both motor and convertor and thus temperature and vibration monitoring are fundamental. This translates in an increase in temperature sensing requirements for correct thermal management and therefore added component count. With motor-drives going at high speeds and high frequency there are challenges for data acquisition and challenges for determining the rotor speed using resolvers. The use of such conventional sensors, for both temperature and position/speed measurements pose a significant reliability overhead. Over the past years optical fibre sensors based on Bragg gratings have been developed for quasi-distributed temperature and strain/vibration measurements. This project therefore aims to explore the possibility of using such technology as a replacement to conventional bulky systems prone to EMI issues whilst at the same time provide a test platform which will provide the necessary feedback on the axial the circumferential distribution of key parameters such as temperature and strain. The same applies in terms of power electronic convertors for heat sink design validation and online device temperature monitoring. Thus the development of such a SMART self-monitoring motor drive provides a method for enhanced reliability and time-to-failure prediction. The purpose of this project is to develop a test setup able to investigate the integration of In-fibre gratings within the electrical drive components including the machine itself and associated power electronics. Work will be done to extract temperature and strain data, this data will in turn be fed-back into lifetime models used to predict/monitor the drive’s operating conditions.

Keywords: optical fibre sensors,fibre bragg gratings,electrical motor drives,smart self-monitoring motor drives
Manufacturing and optimization of a PEEK scroll by fusible core injection moulding (THERMOPLASTIC SCROLL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Netherlands
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-03-01
End date: 2015-09-30
Duration (months): 19.0
Total project cost (EUR): 349980.0
EU funding (EUR): 244350.0
Participants: 1
Project status: CLOSED

Egmond Plastic is the global specialist in the area of fusible core injection moulding in combination with Peek material with carbon reinforced fibres. This technology makes it possible to mould inject complicated hollow parts all at one time, without the need for welding. With more than 20 years experience in fusible core injection moulding for the aerospace industry, this type of production technology has been used for the fuel system components for military and civil aircrafts. The advantage are very obvious, 50% weight reduction as well as a possible 30% cost reduction. The manufacturing of a scroll for the air cycle machine would be a next step for fusible core injection moulding technology. Until today, no company offers the scroll in thermoplastic material. This program will identify, design, and manufacture a scroll made from thermoplastic material (Peek with reinforced carbon fibres), using a fusible core. This program will demonstrate the use of thermoplastic material for this application and will proof that considerable gains are to be expected when making the scroll from thermoplastic material. The expected impact of the program are large. For Clean Sky, considerable weight savings are to be expected, resulting in lower emissions and improved performance. From a technical point of view, it is the next step in technology change for the air cycle machine and it might lead to possible other components to be replaced with a thermoplastic material. From Egmond Plastic, this program provides an opportunity to become the world class leader of fusible core technology for the aerospace industry.

Keywords: fusible,peek,egmond plastic
Sustainable Dismantling and Recycling of Metallic Aerostructures (SENTRY)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain,Spain
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-04-01
End date: 2015-09-30
Duration (months): 18.0
Total project cost (EUR): 300000.0
EU funding (EUR): 225000.0
Participants: 3
Project status: CLOSED

The SENTRY Project deals with the dismantling, recycling and environmental assessment of the End of Life (EoL) phase of “Demonstrator” panels, a subcomponent of “low weight metallic fuselage section” named B2, which has been manufactured within the Eco-Design for Airframe (EDA) activity in the Clean Sky programme. The SENTRY Project will assess the current end of life management practices, namely operations associated to aircraft part dismantling and processes associated to material recycling, and will propose the necessary changes for satisfying an optimal low weight panel dismantling and light metallic alloys recycling. The proposed new procedures will be tested with a live panel dismantling experiment, at an accredited EoL aircraft manager facility, where parts will be identified, separated, sorted and pre-treated (de-coated, shredded, etc.) in order to satisfy input specifications of metal smelters that recycle them. The separated metallic fractions will be processed in a pilot melting facility and the produced metallic alloys characterised in order to validate their close loop recycling as better alternative than the downgrading practice. During dismantling and recycling activities, materials and energy flows, emissions and waste generation will be inventoried in order to complete the Life Cycle Assessment (LCA) of the EoL of the “B2 Demonstrator” panels that will be compared with the one of a reference panel. The final results will be the definition of the new EoL schemes for the “B2 Demonstrator” panels. The assessment of the environmental impacts related to the new EoL will allow the identification of those activities with a strong environmental impact and the definition of eco-design solutions to optimize potential reuse/recycling of metallic materials.

Keywords: lca (life cycle assessment),end of life,aircraft fuselage,b2 demonstrator panel,part dismantling,material sorting,material pre-treatment,metal recycling,light metallic alloys,aluminium alloys
MANUFACTURING OPTIMIZATION OF A PLENUM WITH GFRP CYANATE ESTER-BASED PREPREG (PLENOPTIMUM)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Greece,Spain
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-03-01
End date: 2015-06-30
Duration (months): 16.0
Total project cost (EUR): 299416.0
EU funding (EUR): 224562.0
Participants: 2
Project status: CLOSED

Cyanate ester resins offer significant advantages as composite matrices because of their high thermal stability, their improved toughness, low outgassing, low moisture uptake and radiation resistance due to their low dielectric constant. Towards the direction of incorporating these materials in the aerospace industry, a new glass/cyanate ester material system was characterized for use in the plenum of the air cooling unit of aircrafts. However, the first trials with this new prepreg to manufacture real parts (plenum housing) in an autoclave, highlighted some heterogeneity issues in the reliability and reproducibility of the manufacturing process. PLENOPTIMUM project aims to address the reasons that lead to the aforementioned heterogeneities and through a novel Design of Experiments approach identify a number of possible influential factors that affect the manufacturing process (in autoclave and out-of-autoclave) and potentially cause deviations and heterogeneities. For the first time, factors additional to temperature profile and pressure shall be examined according to their effect on the final quality of the composite materials and the actual plenum. Process modeling as well as online curing monitoring technologies will assist the optimization task and the quest of the optimum curing cycle. Manufacturing trials for plenum manufacturing in an autoclave as well as out-of-autoclave process will take place in the final part of the project taking into account the results of a test campaign specially designed to highlight the effect each one of the identified influential factors has. Guidelines and recommendations to the topic manager and manufacturer that ensure and optimize the manufacturing process are the final outcome. Both participants that form PLENOPTIMUM consortium have a strong background and experience on processing/manufacturing optimization and have the proper infrastructure to meet the targets set.

Keywords: cyanate ester prepreg,autoclave,out-of-autoclave,failure analysis,design of experiments,process modeling and simulations,curing monitoring,optimization,prototype manufacturing