Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gene amplification in squamous cell carcinoma development: mapping of amplification regions on chromosome 3q in precancerous lesions of the upper aerodigestive tract by molecular copy number counting (ASCC3Q)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-01
End date: 2010-09-30
Duration (months): 24.0
Total project cost (EUR): 178874.06
EU funding (EUR): 178874.06
Participants: 1
Project status: CLOSED

Tumors of the upper aerodigestive tract (lung, head and neck, esophageal) are the major cause of cancer related deaths in Europe, with an estimated 436,700 deaths in 2006. No screening for early detection has proven effective and most patients are diagnosed with incurable disease. Squamous cell carcinoma (SCC) is a common histologic type developing via a series of stages from normal epithelium, through metaplasia to dysplasia, then carcinoma in situ and finally invasive cancer. Notably, the majority of the preinvasive lesions reverts back to normal or do not progress. The identification of molecular markers predictive of progression from preinvasive to invasive cancer is the key to develop successful screening tools. Genomic alterations are particularly suitable molecular markers of cancer. The most common genomic abnormality in SCC is gene amplification on chromosome 3q. Despite several candidate oncogene(s) having been identified in this region, due to limits of resolution of current techniques, the minuscule amount of tissue from preinvasive lesions and the fact that most studies were done before the human genome sequence was available, the relevance of these genes in the etiology of SCC is controversial and the precise target(s) of 3q amplification remains ill defined. This project will characterize the 3q amplified region (amplicon) in preinvasive lesions that precede head and neck cancer and lung cancer using molecular copy number counting, a new technique based on PCR, which requires small amounts of DNA and evaluates many genomic loci simultaneously. Mapping of 3q amplicon will be performed on archival and prospectively collected biopsies. We expect to better define the candidate oncogene(s) in this region. These markers, acting as surrogates of pre-cancer, could allow the development of tools to select subjects at higher risk, who might benefit from intense surveillance and/or early treatment and could also be used as endpoints in cancer-prevention trials.

Keywords: health sciences,oncology,squamous cell carcinoma,preinvasive lesions,lung cancer,oral cancer,molecular markers,gene amplification,oncogene,molecular copy number counting,chromosome 3,pcr
Vertices of simple modules for the symmetric and related finite groups (D07.SYMGPS.OX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-07-31
End date: 2011-07-30
Duration (months): 24.0
Total project cost (EUR): 160658.97
EU funding (EUR): 160658.97
Participants: 1
Project status: CLOSED

This project aims to study representations of symmetric groups, alternating groups and other related finite groups, over non-zero characteristic. These representations are far from being semisimple, and many basic problems, like finding the irreducible representations - that is simple modules - are not solved in general. Therefore one needs to find and understand invariants of modules. We will focus on the distiguished classes of Specht modules and simple modules and will investigate vertices, sources, and complexity. These encapsulate local and group theoretic features on the one hand, and large-scale homological behaviour on the other hand. Spectacular new developments from Lie theory have opened up completely new perspectives, and we will combine the classical approach of G.D. James, the new methods originating in Kac-Moody algebras and quantum groups, and work by Kleshchev , Lascoux/Leclerc/Thibon, Ariki, Grojnowski, and Chuang/Rouquier.

Keywords: algebra,modular representation theory,computational mathematics,vertex,source,complexity,simple module,specht module,symmetric group,finite group of lie type,natural sciences
Molecular and Functional analysis of the Integrator complex (INTEGRATOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-01
End date: 2009-07-31
Duration (months): 17.0
Total project cost (EUR): 150802.06
EU funding (EUR): 150802.06
Participants: 1
Project status: CLOSED

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is essential for transcriptional regulation and RNA processing of protein coding genes. A large body of data also implicates the CTD in the transcription and processing of RNAPII-dependant spliceosomal U small nuclear RNAs (U1 to U5 snRNAs). Recently, we discovered a RNA polymerase II complex that contains at least twelve novel subunits, termed the Integrator complex, in addition to core RNAPII subunits. Two of these subunits display similarities to the subunits of the cleavage and polyadenylation specificity factor (CPSF) complex. We showed that the Integrator is recruited to the U1 and U2 snRNA genes and mediates the 3’-end processing of their transcript. The Integrator complex is evolutionarily conserved in metazoans and directly interacts with the CTD of the RNA polymerase II large subunit. This proposal is focused on providing a thorough physical and functional characterization of the Integrator complex. Aim1 will identify the interactions existing between the different subunits of the Integrator complex and between Integrator and the CTD of the RNAPII. Aim2 describes a detailed functional analysis of Integrator in transcriptional regulation and processing of the U snRNAs. Aim3 extends this work by the exploration of other potential targets for the Integrator complex. Elucidation of the mechanisms through which small nuclear RNAs are transcribed and processed is of seminal importance in understanding regulation of gene expression and growth control. Indeed, aberrant regulation of small nuclear RNA processing could result in defective messenger RNA processing through deregulation of the spliceosome, potentially leading to expression of aberrant proteins and adverse outcomes such as cellular transformation and oncogenesis.

Keywords: protein complex,interaction,ctd,small nuclear rna,rna processing,rna recognition,molecular biology,cell biology,genomics
Organometallic Reactions in Carbohydrate Chemistry (ORGMET. CARB.)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-02-15
End date: 2010-01-14
Duration (months): 23.0
Total project cost (EUR): 171831.34
EU funding (EUR): 171831.34
Participants: 1
Project status: CLOSED

The aim of this project is to apply some state of the art transition metal catalysed reactions to carbohydrate systems. We plan to investigate the possibilities of using transition metals to catalyse C-C fond forming cyclisations and C-N bond forming cyclisation and cross-coupling reactions. In carbocyclisation reactions, we will be focussing on ene-yne systems, which will be synthesised from carbohydrate starting materials. Electrophilic transition metal complexes such as gold complexes can induce cyclisation of an alkene onto an activated alkyne. Alternatively, debenzylative etherification may be favoured. Ruthenium complexes can carry out one-pot oxidation-reductive-amination to form secondary amines from primary amines and alcohols. We plan to apply this reaction to the synthesis of amine-linked disaccharides, and also to cyclisation reactions where a carbohydrate-derived diol can cyclise with a primary amine, giving an N-substituted iminosugar or azasugar. A combination approach where alkene and alkyne functionalities are introduced to a molecule by the amine coupling reaction followed by a carbocyclisation will be investigated. The polyhydroxylated products of these reactions will be new or known glycomimetics. The new compounds will be tested for their biological activity by our collaborators.

Keywords: organometallic chemistry,carbohydrates,glycomimetics,reductive amination,ene-yne cyclisation
Normative or Strategic Power Europe? Conceptualising the European Union’s Power in the Wider European Neighbourhood (POWEREUROPE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 151269.28
EU funding (EUR): 151269.28
Participants: 1
Project status: CLOSED

This project aims at conceptualising the European Union’s (EU) power in the wider European neighbourhood through studying the compliance responses of non-EU countries to the EU’s conditions for further inclusion in the European integration project and how these responses are affected by domestic views of the purpose of the EU’s actions. Drawing on empirical evidence from southern and eastern neighbouring states, the project will first investigate the driving forces behind the EU’s policy in the Mediterranean and East Europe and will draw conclusions about the strategic and normative dynamics at the EU decision-making level. Second, it will explore how domestic actors in selected countries perceive the motivation of the EU’s policy and how they react to it. Of particular interest will be the aim of delineating how legitimate the EU’s actions are from the viewpoint of key political players in the respective non-EU states and how this perception affects their privileging of strategic or normative factors in their compliance responses. The two-step analysis will lay the ground for a theoretical synthesis of the EU’s power in the wider European neighbourhood. The working hypothesis is that the legitimacy of the EU’s policy is a key determinant of its lasting impact on non-EU countries. The EU will have more success when its more coercive means support a policy goal easy to justify on normative grounds. On the contrary, when the EU exercises influence against what is stands for as a community of values, its leverage weaker. The project’s contribution can be evaluated through the prism of its innovative methodological approach, original argument and attempted bridging of the Europeanization literature and the foreign policy analysis literature. Through implementation of the project, I expect to strengthen my research aptitude, improve my publication skills, reinforce my research management qualities and diversify my collaborative research networks.

Keywords: international relations,european foreign policy,european neighbourhood policy,legitimacy,compliance,europeanization,eu conditionality
Functional connectivity of developing hippocampal networks: characterization of “circuit-hubs” (CIRCUIT-HUBS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 24.0
Total project cost (EUR): 162509.69
EU funding (EUR): 162509.69
Participants: 1
Project status: CLOSED

Oscillatory activity synchronized over a large population of neurons is the signature of the developing brain and play a major role in the construction of neuronal circuits. The hypothesis at the basis of our research proposal is that the initiation of synchronous network events is dependent on precise connectivity patterns of the neuronal network. Models of complex systems and networks offer solid tools to characterize mathematically the dynamics of neural circuits and predict the existence of networks “hubs”, i.e. neurons with spread and much larger number of connections, which strongly influence the state of the network. The aim of the present project is to identify specific types of neurons driving the oscillatory activity in the hippocampus during development. In order to find network “hubs”, the activity in neuronal circuits must be first measured with a high spatiotemporal resolution. Fast multibeam two-photon calcium imaging represents the most accurate experimental system to measure the activity of large populations of neurons with single-cell resolution and will be used for the experiments. Online analysis of the network temporal dynamics will identify candidate hubs. Patch clamp recordings from these neurons while imaging will further characterize the relationship between the state of the neuron and network dynamics. Morphological reconstruction and neurochemical characterization of recorded hubs will be performed post hoc. Offline accurate mathematical analysis will reconstruct and compare the temporal dynamics of the network in control conditions and during hub stimulation. My previous studies on neuronal circuits using multi-electrode arrays and my background in Physics give me the necessary experimental and theoretical background to carry on this study and we have already obtained very encouraging preliminary results. This novel approach will be of interest to a wide audience of researchers spanning from experimental neurobiology to network theory.

Keywords: interneurons,gaba,development,oscillations,neuronal networks,hubs,two-photon imaging
Internal exposure – in tissue equilibrium sampling to bridge the missing link between bioavailability and bioaccumulation (INTERNAL EXPOSURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-15
End date: 2011-10-14
Duration (months): 42.0
Total project cost (EUR): 177320.91
EU funding (EUR): 177320.91
Participants: 1
Project status: CLOSED

The training program is designed for Annika Jahnke, a very talented young researcher who has successfully completed her doctoral studies on polyfluorinated alkyl substances in the marine atmosphere. The proposed 24-month project seeks to extend her competencies to internal exposure, bioaccumulation and bioavailability of organic contaminants. The missing link between external concentrations of persistent organic pollutants (POPs) and their levels at target sites in organisms where adverse effects occur will be investigated. This research issue is fundamental for risk assessment of contaminants. The training program consists of three research objectives: (1) Internal exposure: Develop equilibrium sampling methods to measure chemical activity / fugacity of POPs in biota; use them to test the hypothesis that POP fugacity is the same in different tissues throughout a given organism. (2) Bioaccumulation: Explore bioaccumulation in marine food webs from the Baltic Sea by measuring the fugacity of a given POP at different trophic levels. (3) Bioavailability: Develop methods to measure the freely dissolved concentration of POPs in water and sediment, which is equivalent to the chemical activity / fugacity. Use them together with the above methods to explore bioavailability effects on bioaccumulation, and to determine differences in POP fugacity between benthic and pelagic organisms as well as their respective environments. An additional component of the training program will provide the applicant with important complementary competencies including research supervision and project management. This completes a program which is carefully matched to the applicant´s needs and exploits the unique possibilities at Stockholm University and the Danish National Environmental Research Institute. With the experience gained in this project, the talented applicant will be well prepared for a successful independent research career.

Keywords: environmental chemistry,marine ecosystems and processes,equilibrium sampling devices,internal exposure,bioavailability,bioaccumulation,chemical activity,persistent organic pollutants (pops)
Injected Spin Lasers (ISLAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-01
End date: 2010-12-31
Duration (months): 24.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

This proposal is concerned with vertical-cavity surface-emitting lasers (VCSELs) where the output polarisation is controlled by the injection of spin-polarised electrons. These spin-polarised lasers offer many attractive advantages, including enhanced intensity and polarisation stability as well as a reduced threshold current. However, the focus of the present proposal is on the effects of polarised optical injection on the nonlinear dynamics of spin-polarised lasers. Nonlinear dynamics of optically-injected semiconductor lasers has been a fertile research topic for many years and the benefits are now beginning to be seen in stable injection-locked sources with very high bandwidths as well as in potential applications in encrypted communications systems based on chaos. By combining the hitherto disparate fields of spin-polarised VCSELs and optical injected lasers this proposal opens an entirely new research avenue of fundamental importance with many routes to potential applications. The effects of polarised optical injection in conventional VCSELs will be studied first, both experimentally and theoretically, and the model predictions will be compared with the experimental results. In addition to generating results of fundamental interest, these comparisons will be used to build confidence in the modelling capability and to adjust parameter values to optimise the model. This experience will then be used to develop a model for polarised optical injection in spin-polarised VCSELs and use it to analyse effects such as polarisation switching, bistability, limit cycle, period doubling and chaos, and to seek novel effects. This project will generate fundamental understanding of the dynamics of spin-controlled lasers that is required to unlock potential applications in coherent detection systems, cryptography, magneto-optical recording, optical switches, reconfigurable optical interconnects and telecommunications with enhanced bandwidth.

Keywords: electrical engineering,optoelectronics,photonic components,spin-polarised lasers,vertical-cavity surface emitting laser (vcsel),polarised optical injection,nonlinear dynamics.
Polypalladated Arenes: Synthesis, Characterization and Reactivity. Applications in Organic Synthesis (POLYPALLADATEDARENES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-02-05
End date: 2011-02-04
Duration (months): 24.0
Total project cost (EUR): 151936.08
EU funding (EUR): 151936.08
Participants: 1
Project status: CLOSED

The organometallic chemistry of palladium is a research field of great importance and enormous potential worldwide, mainly due to its applications in organic synthesis. Arylpalladium complexes are especially important, as they are involved in many catalytic carbon-carbon and carbon-heteroatom bond forming reactions. It is commonly observed that the presence of a suitable substituent in ortho to the Pd atom influences the reactivity of the complex and the formation of organic compounds. In this project we aim to extend this successful chemistry to polypalladated arene complexes of general formula [1,3,5-C6R3(PdXL2)n], where n=1-3 and R is a functionalized organic group. The target complexes will be synthesised through oxidative addition reactions of the corresponding polyhalogenated arenes 1,3,5-C6R3X3 (X= I, Br) to Pd(0) compounds. The reactivity of the resulting (poly)palladated complexes towards unsaturated molecules, such as alkenes, alkynes, isocyanides and carbon monoxide will be investigated, with the aim of obtaining new polypalladated complexes resulting from insertion reactions and/or organic compounds of interest resulting from decomposition reactions. Some preliminary results have already been obtained by the applicant, who is currently carrying out a short visit in the host research group. Possible applications of this research in the development of catalytic processes in organic synthesis will be pursued as well. The project also involves the extensive application of modern NMR techniques to the structural characterization of the products, as well as to the investigation of dynamic processes, reaction mechanisms and, in general, to the resolution of problems in organometallic chemistry.

Keywords: catalysis,coordination chemistry,inorganic chemistry,insertion reactions,nuclear magnetic resonance,organic synthesis,oxidative addition,organometallic,palladium,polypalladated arenes
Integral formulae and extrinsic geometry of foliations (EXTGEOMFOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-06
End date: 2010-10-05
Duration (months): 24.0
Total project cost (EUR): 161533.53
EU funding (EUR): 161533.53
Participants: 1
Project status: CLOSED

The project concerns investigations of the extrinsic geometry (expressed by the 2nd fundamental form of leaves) and its relations with mixed curvature, topology and dynamics of foliations on compact (or of finite volume) manifolds. The research objectives are to go deeply in studying foliations using the methods of Riemannian geometry, theory of submanifolds, topology and dynamics, computer simulations. Among the (hoped for) results are new integral formulae for foliations on Riemannian manifolds, connectedness properties of (k, ε)-saddle (saddle, totally geodesic) foliations, and applications of them to the following problems: – Walczak problem: to recover a metric on a foliated manifold by higher mean curvatures of a foliation or its orthogonal distribution; – Gluck-Ziller problem: minimizing certain functions like volume and energy defined for plane fields on Riemannian manifolds, considered as maps into the (co)tangent Grassmann bundles equipped with Cheeger-Gromoll type metrics; – Toponogov problem: to generalize Ferus’s theorem for the case of foliations with non-negative (positive) mixed curvature. The topic belongs to differential geometry and topology, subjects of pure mathematics.

Keywords: foliation,riemannian manifold,extrinsic geometry,mixed curvature,higher mean curvature,grassmann bundle,volume