Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Beta-cell function in juvenile diabetes and obesity (BETA-JUDO)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Sweden,Luxembourg,Austria,United Kingdom,Germany,Switzerland,United Kingdom,Germany,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-02-01
End date: 2016-11-30
Duration (months): 58.0
Total project cost (EUR): 7957282.0
EU funding (EUR): 5999779.0
Participants: 12
Project status: CLOSED

The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we propose insulin hypersecretion as an etiological factor promoting lipid deposition, insulin resistance, cellular dysfunction and death in insulin-producing beta-cells and insulin-target brown adipocytes. Pharmacology-based treatment strategies are limited for this growing patient group and the aim of the proposal is to identify novel strategies reducing insulin hypersecretion, which has not been considered a target for intervention in young obese individuals. To address the issue, pediatric obesity clinics and academic centres with focus on beta-cell biology, brown adipocyte imaging, transcript and protein profiling, genetics, epidemiology and bioinfomatics have formed a consortium with two SMEs specialized on biomarker discovery and clinical trials and one large drug company. In the project well-characterized European patient cohorts of more than 3000 obese children will be further characterized with regard to insulin secretion and brown adipocyte mass. Currently used drugs and new principles of intervention based on novel genes, idenitifed in the project and linked with insulin hypersecretion, will be examined for effects on insulin hypersecretion in translational work including the young obese subjects and isolated human islets. Following comprehensive analysis candidate compounds/principles attenuating insulin hypersecretion will be selected, from which novel therapeutic strategies are expected to emerge. Such therapeutic strategies will be of importance for afflicted individuals and European health economy and lead to new opportunities for European industry.

Keywords: diabetes,obesity,treatment,beta-cell,insulin hypersecretion
Direct and Indirect Searches for New Physics with Diboson Final States at ATLAS (DIBOSON)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-12-01
End date: 2016-11-30
Duration (months): 60.0
Total project cost (EUR): 904190.0
EU funding (EUR): 904190.0
Participants: 1
Project status: CLOSED

The Large Hadron Collider (LHC) at the European Organisation for Nuclear Research (CERN) promises a major step forward in the understanding of the fundamental nature of matter. Four large experiments at the LHC are complementary addressing the question of the origin of our Universe by searching for the so-called New Physics. The ”Standard Model” (SM), the theory that reflects our understanding of elementary particles and their fundamental interactions, has been extensively studied and experimentally verified to an unprecedented precision over the past decades. Despite its impressive success, there are many unanswered questions; which suggest that there is a more fundamental theory which incorporates New Physics. It is expected that at the LHC either New Physics beyond the SM will be discovered or excluded up to a very high energies, thus our view of the fundamental structure of the Universe will be challenged and probably revolutionized in the coming years. The ATLAS experiment is dedicated to address the key issue of ElectroWeak Symmetry Breaking (EWSB) and linked to this the search for the Higgs boson as well as the search for Physics beyond the Standard Model. The analysis proposed here is measurement and searches for New Physics in diboson processes . The New Physics effects in the diboson sector will be observed either directly, as in the case of new particle production decaying to diboson, e.g., new vector bosons and extra-dimensions, or indirectly through deviations from the SM predictions of observable such as cross sections and asymmetries. Triple gauge boson self-coupling (TGC) are extremely sensitive to New Physics, thus a very powerful tool for indirect searches for New Physics contributions through loop corrections. At the LHC, the unprecedented center-of-mass energy and luminosity will allow to measure the TGC with a high accuracy and to probe regions that are inaccessible at previous experiments even with modest amounts of data.

Keywords: particle physics
Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations (MEDIGENE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,France,Spain,Spain,Romania,Italy,Italy,Greece,Tunisia,Algeria,Morocco,Albania,Finland,Türkiye,Croatia,Russian Federation,Hungary
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2016-07-31
Duration (months): 55.0
Total project cost (EUR): 4373149.8
EU funding (EUR): 2996907.0
Participants: 23
Project status: CLOSED

MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and North Africa. Archaeogenetic studies in Europe indicated that Y chromosome and mitochondrial DNA patterns or Ancestry Informative Markers (AIMs) revealed a close relationship between genetic and geographic distances able to locate an individual DNA within few hundred kilometers. The project will use this information in mapping the genetic basis of insulin resistance, cardiovascular and metabolic complications in immigrants (Albanians, Romanians, Turkish, Tunisians, Algerians and Morocco) in host countries France, Spain, Italy and Greece. Ancestry markers and studies on ancient DNA from Roman historical migration in Catalonia will help to give a better picture of the genetic landscape of Europe and North Africa. Genes for MetS will be studied in existing samples from host and home countries by GWAS, locus refining by next-generation sequencing and haplotype mapping. Informative filtered SNPs will be then used in epidemiology and novel DNA samples to reveal G x E interactions and specificities of the pathogenesis of MetS. Genetic findings will be replicated in home countries (Anatolia and North Africa) in the goal to develop markers ethnic specific and significant at a clinical scale. Major impact is expected from dissemination of our findings to prevent the occurrence of MetS and obesity in children and adolescents or in descendants of modern immigration, understanding variability clinical manifestations of MetS in the context of malnutrition and from the novel approach of GWAS strategies by ameliorating the association signal and bursting R&D activities of SMEs.

Keywords: metabolic syndrome,mediterranean countries,gene,gwas,haplotype
Bringing Regenerative Medicine into the market: Allogeneic eASCs Phase IB/IIA clinical trial for treating Rheumatoid Arthritis (REGENER-AR)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Spain,Netherlands,United Kingdom,France,Spain,Spain,Belgium,Spain,United Kingdom
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 7644045.6
EU funding (EUR): 5925461.5
Participants: 10
Project status: CLOSED

Treating Rheumatoid Arthritis (RA) is a crucial challenge for the health systems. RA is the most common inflammatory arthritis, affecting 0.5% to 1% of the general population worldwide with little variation of the prevalence among countries. The current pharmacological management of RA involves early intervention with synthetic disease modifying anti-rheumatic drugs (DMARDs) either singly or in combination. Despite all those treatments, RA remains as an unmet clinical need where several concerns about long term treatments based on biologics have been arisen (Bongartz, 2009) while there are still approximately 20-40% of rheumathoid arthritis patients that do not have an adequate response to anti-TNF (Vander CB, 2006). The preclinical data obtained by the REGENER-AR consortium in a RA efficacy model in mice using allogeneic eASCs by intravenous route, demonstrated that mesenchymal expanded adult stem cells (eASC) extracted from adipose tissue have a large potential for treating RA. REGENER-AR consortium has defined a clinical translational project which aim is to develop a broadly available and clinically applicable treatment for RA by exploiting the biology of living human eASCs. To do that, the consortium is developing an Advanced Therapy Medicinal Product (ATMP) based on allogeneic eASCs for the treatment of RA (product internal code, Cx611) and ready for starting the clinical research (IMPD and clinical protocol has been approved by the regulatory agencies in January 2011). To accomplish this goal, it will be necessary to test this product through a phase Ib/IIa clinical trial in order to define the safety and feasibility of the systemic administration of allogeneic eASCS in patients with RA, but it will be necessary as well to advance in the difficulties that prevent cell therapy to be considered as a largely available product in the market facing several issues related to the production scale-up, effectively clinical treatment and regulatory affairs compilance

Keywords: regenerative medicine,clinical trial,eascs,reumathoid arthritis,allogenic.
NanoElectroMechanical Systems based on Carbon Nanotube and Graphene (CARBONNEMS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Spain
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1996788.74
EU funding (EUR): 1996788.74
Participants: 2
Project status: CLOSED

Carbon nanotubes and graphene form a class of nanoscale objects with exceptional electrical, mechanical and structural properties. I propose to exploit these unique properties to fabricate and study various nanoelectromechanical systems (NEMS) based on graphene and nanotubes. Specifically, I will address two directions with major scientific interests: 1- I propose to study electromechanical resonators based on an individual nanotube or on a single layer of graphene. My group has a leading position in this recent research field and the idea is to take advantage of our expertise for two sets of experiments, one on inertial mass sensing and one on the exploration of quantum motion. These two topics are generating at present an intense activity in the NEMS community. Experiments are usually carried out using microfabricated silicon resonators but the ultra low mass of nanotubes and graphene has here an enormous asset. It drastically improves the sensitivity of mass sensing and it dramatically enhances the amplitude of the motion in the quantum regime. 2- My team will fabricate and exploit nanomotors based on nanotube and graphene. Only few man-made nanomotors have been demonstrated so far. Reasons are multiple. For instance, the fabrication of nanomotors is technically challenging. In addition, friction forces are often so strong that they hinder motion. Because of their unique properties, nanotubes and graphene represent a material of choice for the development of new nanomotors. We will construct nanomotors with different layouts and address how electrical, thermal or chemical energy can be transformed into mechanical energy in order to drive motion at the nanoscale.

Keywords: graphene,carbon nanotubes,nems,catalytic motors,quantum transport
New Approaches to Network Design (NEWNET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Switzerland,Italy
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1122199.2
EU funding (EUR): 1122199.2
Participants: 2
Project status: CLOSED

Networks pervade every aspect of nowadays life. This is one of the reasons why their design, management, and analysis is one of the most active areas of theoretical and empirical research in Computer Science and Operations Research. The main goal of this project is to increase our theoretical understanding of networks, with a special focus on faster exact exponential-time algorithms and more accurate polynomial-time approximation algorithms for NP-hard network design problems. We will consider classic, challenging open problems in the literature, as well as new, exciting problems arising from the applications. These problems will be addressed with the most advanced algorithmic and analytical tools, including our recently developed techniques: iterative randomized rounding, core detouring, and randomized dissection. A second, ambitious goal of this project is to stimulate the interaction and cross-fertilization between exact and approximation algorithms. This might open new research horizons.

Keywords: network design,approximation algorithms,exact exponential algorithms
Higher dimensional general relativity: explicit solutions and the classification and stability of black holes. (HIDGR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: ERC Starting Grant Interdisciplinary Panel
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1337044.0
EU funding (EUR): 1337044.0
Participants: 1
Project status: CLOSED

Higher-dimensional General Relativity (GR) is well-motivated by string theory e.g. via the gauge/gravity correspondence or scenarios that predict black hole production at the Large Hadron Collider. In this proposal it is regarded as a self-contained mathematical subject that extends conventional 4d GR. It is known that higher-dimensional GR exhibits qualitative differences from 4d GR, especially for black holes, e.g. there exist "black ring" solutions describing rotating, donut-shaped black holes. It is likely that there are many other interesting solutions. This project will investigate the following topics in higher-dimensional GR: 1. Methods for obtaining explicit solutions of the Einstein equation, especially those based on algebraic classification of the Weyl tensor; 2. Classical stability of black holes; 3. Classification of black hole solutions: What data is required to specify uniquely black hole solutions? What are the allowed topologies and symmetries of black holes?

Keywords: general relativity,extra dimensions,explicit solutions,black holes
The Gamma Ray Burst – Supernova Connection and Shock Breakout Physics (GRB-SN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: Israel
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2017-12-31
Duration (months): 72.0
Total project cost (EUR): 1468180.0
EU funding (EUR): 1468180.0
Participants: 1
Project status: CLOSED

Long gamma ray bursts (long GRBs) and core-collapse supernovae (CCSNe) are two of the most spectacular explosions in the Universe. They are a focal point of research for many reasons. Nevertheless, despite considerable effort during the last several decades, there are still many fundamental open questions regarding their physics. Long GRBs and CCSNe are related. We know that they are both an outcome of a massive star collapse, where in some cases, such collapse produces simultaneously a GRB and a SN. However, we do not know how a single stellar collapse can produce these two apparently very different explosions. The GRB-SN connection raises many questions, but it also offers new opportunities to learn on the two types of explosions. The focus of the proposed research is on the connection between CCSNe and GRBs, and on the physics of shock breakout. As I explain in this proposal, shock breakouts play an important role in this connection and therefore, I will develop a comprehensive theory of relativistic and Newtonian shock breakout. In addition, I will study the propagation of relativistic jets inside stars, including the effects of jet propagation and GRB engine on the emerging SN. This will be done by a set of interrelated projects that carefully combine analytic calculations and numerical simulations. Together, these projects will be the first to model a GRB and a SN that are simultaneously produced in a single star. This in turn will be used to gain new insights into long GRBs and CCSNe in general. This research will also make a direct contribution to cosmic explosions research in general. Any observable cosmic explosion must go through a shock breakout and a considerable effort is invested these days in large field of view surveys in search for these breakouts. This program will provide a new theoretical base for the interpretation of the upcoming observations.

Keywords: gamma-ray bursts supernova
Numerical integration of Geometric Partial Differential Equations (GEOPARDI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 971772.0
EU funding (EUR): 971772.0
Participants: 1
Project status: CLOSED

The goal of this project is to develop new numerical methods for the approximation of evolution equations possessing strong geometric properties such as Hamiltonian systems or stochastic differential equations. In such situations the exact solutions endow with many physical properties that are consequences of the geometric structure: Preservation of the total energy, momentum conservation or existence of ergodic invariant measures. However the preservation of such qualitative properties of the original system by numerical methods at a reasonable cost is not guaranteed at all, even for very precise (high order) methods. The principal aim of geometric numerical integration is the understanding and analysis of such problems: How (and to which extend) reproduce qualitative behavior of differential equations over long time? The extension of this theory to partial differential equations is a fundamental ongoing challenge, which require the invention of a new mathematical framework bridging the most recent techniques used in the theory of nonlinear PDEs and stochastic ordinary and partial differential equations. The development of new efficient numerical schemes for geometric PDEs has to go together with the most recent progress in analysis (stability phenomena, energy transfers, multiscale problems, etc..) The major challenges of the project are to derive new schemes by bridging the world of numerical simulation and the analysis community, and to consider deterministic and stochastic equations, with a general aim at deriving hybrid methods. We also aim to create a research platform devoted to extensive numerical simulations of difficult academic PDEs in order to highlight new nonlinear phenomena and test numerical methods.

Keywords: geometric numerical integration,hamiltonian pdes,stochastic differential equations,hybrid methods
Analysis of the Dark Universe through Lensing Tomography (ADULT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1316880.0
EU funding (EUR): 1316880.0
Participants: 1
Project status: CLOSED

The discoveries that the expansion of the universe is accelerating due to an unknown “dark energy” and that most of the matter is invisible, highlight our lack of understanding of the major constituents of the universe. These surprising findings set the stage for research in cosmology at the start of the 21st century. The objective of this proposal is to advance observational constraints to a level where we can distinguish between physical mechanisms that aim to explain the properties of dark energy and the observed distribution of dark matter throughout the universe. We use a relatively new technique called weak gravitational lensing: the accurate measurement of correlations in the orientations of distant galaxies enables us to map the dark matter distribution directly and to extract the cosmological information that is encoded by the large-scale structure. To study the dark universe we will analyse data from a new state-of-the-art imaging survey: the Kilo- Degree Survey (KiDS) will cover 1500 square degrees in 9 filters. The combination of its large survey area and the availability of exquisite photometric redshifts for the sources makes KiDS the first project that can place interesting constraints on the dark energy equation-of-state using lensing data alone. Combined with complementary results from Planck, our measurements will provide one of the best views of the dark side of the universe before much larger space-based projects commence. To reach the desired accuracy we need to carefully measure the shapes of distant background galaxies. We also need to account for any intrinsic alignments that arise due to tidal interactions, rather than through lensing. Reducing these observational and physical biases to negligible levels is a necessarystep to ensure the success of KiDS and an important part of our preparation for more challenging projects such as the European-led space mission Euclid.

Keywords: weak gravitational lensing