Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ACD856 - Revolutionising Alzheimer’s disease treatment through disease-modifying and cognitive-enhancing therapy (NeuroRestore ACD856)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-08-01
End date: 2028-07-31
Duration (months): 36.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Alzheimer’s Disease (AD) is a growing public health crisis, affecting millions of people worldwide with a steady cognitive decline. Current treatments offer only temporary symptomatic relief and fail to address the underlying disease progression. As the population ages, the prevalence of AD is expected to double by 2050, placing an immense burden on caregivers and healthcare systems struggling to provide long-term care. AlzeCure, a clinical-stage biotech company, has developed ACD856, a first-in-class small molecule designed to treat AD by enhancing neurotrophic pathways such as Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), which are essential for maintaining neuronal health and cognitive function. ACD856 not only improves cognitive abilities but also has the potential to modify the course of the disease, a breakthrough that sets it apart from existing treatments. Administered orally, it efficiently crosses the blood-brain barrier and has demonstrated a strong safety profile in Phase I trials. AlzeCure plans to advance ACD856 through a Phase II clinical trial under the EIC Accelerator project, aiming to demonstrate its efficacy and further refine its GMP manufacturing processes. This will trigger an out-licensing agreement with a major pharmaceutical partner, paving the way for a market launch by 2033. The partnership strategy includes milestone payments of up to €250M, positioning ACD856 for blockbuster potential with projected peak annual sales of €7 billion by 2037. AlzeCure's work aligns with the European Union’s priorities under the European Health Union initiative, aiming to reduce the social and economic burden of AD. ACD856 has the potential to improve patient outcomes, lower healthcare costs by delaying the need for long-term care, and strengthen Europe's leadership in innovative, disease-modifying therapies.

Keywords: alzheimer s disease small molecule neurotrophins cognitive enhancement disease modification synaptic plasticity brain derived neurotrophic factor nerve growth factor
Assessing the added value of a family component integrated into a multi-tiered system of support targeting kindergarteners’ numeracy and social-emotional behaviour skills (MTSS-K Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Luxembourg,Cyprus
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 34.0
Total project cost (EUR): 485591.25
EU funding (EUR): 485591.25
Participants: 2
Project status: CLOSED

One of the MTSS-K project core objectives is concerned with assessing the impact and cost-effectiveness of the schoolwide Multi-Tiered Systems of Support (MTSS) approach on literacy, numeracy, and social emotional behaviour (SEB) skills of kindergarteners in five European countries through two multi-country clusters randomized controlled trials (RCTs) (RCT1 in numeracy and SEB, RCT2 in literacy and SEB), and another objective is to explore the relevance of integrating a family component into the MTSS approach. The latter objective could be reached by conducting a third RCT in Cyprus and Luxembourg through the Hop-on funding. A sample of 60 classrooms from 60 different schools will be randomly assigned to the experimental condition (SEB+Numeracy+Family) or to the control group. The MTSS-K Hop-on will improve parental involvement in children’s numeracy and SEB learning for at least 900 families in Luxembourg and Cyprus. About 900 more children from the control group will benefit in the same way after the project ends. The intervention activities and assessments as well as any other developments will be made available, through the MTSS-K website and other platforms, to parents/families, teachers, policymakers and the general public, and the results will be disseminated based on FAIR principles and within the open science framework. At system level, regional actors in the R&I process such as the Education Ministry, children/families, teachers, and academia will benefit from UNIC’s participation regarding the efficiency and effectiveness of investment in high quality early childhood education and training. At organisation level, the integration of a family component into a new education model in Europe will improve UNIC’s research excellence and will provide access to new talent pool. At the new partner level, UNIC will extend its knowledge regarding the MTSS development and implementation, and develop communication, dissemination and exploitation skills.

Keywords: multi tiered system of support,family,numeracy,social emotional difficulties
Transforming Digital Accessiblity (PROTEUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ByoWave aims to transform digital accessibility. Every day, millions of persons with disabilities are left behind by conventional technology. That is why ByoWave has developed the Proteus Controller ecosystem, integrating emerging technologies like IoT, smart tech, and big data analytics to revolutionize how users interact with digital devices. ByoWave is dedicated to creating cutting-edge solutions that empower individuals with disabilities, allowing them seamless access to the digital world. Developed from ByoWave’s ecosystem, its first accessibility product on the marketplace, the Proteus Controller, is a modular kit that lets users build a custom device tailored to their needs. Understanding individual needs is key, which has led to the development of the Controller Matchmaking System. This powerful tool uses smart inference to analyse user data from the extensive ByoWave databank, matching users with the optimal controller configuration, dramatically reducing the time it takes to find the perfect setup. Expanding the impact, the Proteus Accessible Technology Platform offers a comprehensive B2B solution for hospitals and businesses. It manages and tracks the use of adaptive devices, enhancing operational efficiency and providing insights into user performance over time. This platform evolves with its users, adapting to feedback and telemetry to continuously improve and personalize the user experience. It is not just technology; it is a gateway to greater independence and productivity ByoWave is not just building products; it is creating communities and fostering environments where everyone can thrive. It is redefining what is possible in accessibility and continue to break down barriers.

Keywords: disabilities,digital,accessibility,ai,gaming,smart tech,big data analytics
New Sustainable Safe Steel for Automotive Components (NES3ACOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

In the current climate emergency and energy crisis, the need to reduce energy and raw material consumption is undoubtedly imperative in the context of a more environmentally and resource-conscious society. Bearing in mind that steel is the most produced metallic material in the world, 1900 million tonnes per year, it is not surprising that a large number of scientific and technological resources are devoted to simplifying its compositions, improving its properties, and optimizing the necessary processing. In line with this, in this proposal, New Sustainable Steel For Automotive Components NES3ACOM, we have found a niche of study and development in which we intend to develop a new steel, belonging to the Medium Manganese Steels (MMS) family, which can be used to manufacture two security components for the automotive industry, one for anti-intrusion and the other for energy absorption, by means of two types of specific processing, more energy efficient than those currently used. While in the case of Anti-Intrusion, a homogeneity in the chemical composition of the different microstructural phases is pursued, in the case of Energy Absorbing the heterogeneity of these compositions will be exploited, which is a product of the steel manufacturing process and therefore innate to it. In the framework of the NES3ACOM project, during the design process of this alloy, a plethora of processing parameters, solid-state phase transformation theories of steels, microstructure-processing relationships, properties-microstructure, etc. will have to be combined and taken into account in order to obtain, after processing the steel, the optimum microstructures whose properties equal or improve those required for the two applications at a lower environmental cost than at present.

Keywords: medium manganese steels,phase transformation,heat treatment,martensite,intercritical annealing
Long-Run Inequalities in Health and Survival Between Families and Across Generations (Relative Health)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Sweden,Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499964.0
EU funding (EUR): 1499964.0
Participants: 2
Project status: SIGNED

Worldwide life expectancy has increased strongly over the past decades, but social inequalities in health and mortality are large and increasing. In contrast to trends in socioeconomic inequality and social mobility, long-term developments in inequality in health and mortality have been poorly documented. “Relative Health” aims to quantify the level of inequality in health and mortality from a family perspective 1800-today. Characteristics that affect health and mortality accumulate in families, and thus the level of inequality in health and mortality can be quantified by addressing similarities within families in health and mortality (same-generation relatives) and intergenerational persistence of health and survival (ancestors and descendants). The project has four main objectives: 1. Develop new ways to measure inequality in health and mortality using a revolutionary new perspective, inequality between families and intergenerational persistence; 2. Using these, describe for the first time long-term trends in health and mortality inequality; 3. Identify mechanisms that shape these inequalities between families and across generations; 4. Identify the role of contextual characteristics in shaping inequalities between families, including the level of social mobility and social inequality. State-of-the-art population reconstructions cover up to 9 generations of relatives (grandparents, parents, children) in Sweden, Netherlands, and US 1800-today and contain lifespan and health information. The project lays the groundwork to generalize these estimates of family health inequality to many contexts with less abundant data sources, using survey data. These contain indicators of health and mortality for focal individuals, their siblings and children for a range of low- and middle-income countries covering 4 decades (DHS, 1984-2018). Overall, the project seeks to transform our understanding of social inequality in health and mortality across time and space.

Keywords: demography,historical demography
Strategic Synergies Cluster XKIC BP 23-25 Proposal (Strategic Synergies)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Knowledge and Innovation Communities
Countries involved: Belgium,Germany,Spain,France,Netherlands
Call: EIT Cross-KIC Strategic Synergies (HORIZON-EIT-2023-2025-KIC, 2023)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 13394681.76
EU funding (EUR): 13394681.26
Participants: 15
Project status: SIGNED

The mission of the EIT Community Strategic Synergies (EIT CSS) is to facilitate and foster collaboration across EIT Community in key thematic areas identified in the EIT SIA 2021-207 and EU policy priorities. By bringing together and promoting cooperation across the different KICs involved, the EIT SCC elevates the EIT Community’s visibility and impact in key areas to drive a systemic change in Europe. By gathering EIT Community’s answers to strategic challenges in one cluster, the EIT CSS creates links between programs that would otherwise never meet, it increases scalability of actions and results, it improves efficiency in terms of management and implementation of processes, and attract new sources of fundings. The EIT CSS builds on the diverse expertise and knowledge of the KICs involved and, inspired by the holocaracy management framework yet aligned with EIT’s recommendations, it positions itself as unique community to address some of today’s most pressing challenges for Europe in four areas: : 1. Artificial Intelligence: by providing solutions for a human-centric implementation of AI that can best address its societal, business, environmental and regulatory challenges but also contributing to the ambitious Deep Tech Talent Initiative (DTTI) initiave; 2. New European Bauhaus (NEB)by supporting community-based capacity building initiatives and start-ups to accelerate the shift towards a more sustainable, inclusive, and beautiful Europe and contributing therefore to the Green Deal; 3. Women Entrepreneurship: by promoting a more inclusive entrepreneurial ecosystem, mainstreaming business opportunities and increased the share of women-led innovation in the market; 4. Circular Economy: facilitating the shift from a linear to a circular economy model by connecting and engaging the different stakeholders of the innovation ecosystem.

Keywords: new european bauhaus,woman entrepreneurship
SpIn-orbitronic QuAntum bits in Reconfigurable 2D-Oxides (IQARO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,France,Denmark,Poland,Sweden
Call: EIC Pathfinder Challenge: Alternative approaches to Quantum Information Processing, Communication, and Sensing (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 3717545.25
EU funding (EUR): 3717545.25
Participants: 10
Project status: SIGNED

The quest for the realization of "fault tolerant" quantum computation is currently challenged by the extreme fragility of quantum effects with respect to noise and decoherence. Quantum control, quantum initialization, read-out and enhanced coherence remain the main challenges which need to be addressed in a scalable multi-qubit platform. In the last few years there were tremendous advancements in the field of spin-orbitronics where the spin-degrees of freedom are manipulated with electric fields through the spin-momentum locking of the electrons. In spite of its importance, this property of materials characterized by large and tunable spin-orbit coupling (SOC), such as two-dimentional (2D) oxide materials, is not fully exploited in quantum computation. Here, we propose spin-orbitronics qubits and their experimental realization in single and double quantum dots based on 2D electron gases (2DEGs) formed at SrTiO3-based oxide interfaces. Due to their large spin-orbit splitting and gate-tunability, oxide interfaces are characterized by an exceptional degree of spin-momentum locking, and at the same time by a unique combination of high-mobility and 2D-magnetism. The exploitation of largely tunable SOC and spin-polarization in 2D systems, in combination with tunabilty of the host materials, is very attractive for a novel quantum computation platform as it allows a coherent quantum control of individual electron spins using spin to charge interconvertion. The proposed platform has all the characteristics for the practical implementation of an innovative quantum computation approach which allows upscaling to a large qubit numbers and goes beyond the one-dimensional interconnect schemes with important fundamental and technological advantages based on spin-orbitronics.

Keywords: spin orbit qubit spin orbitronics quantum control 2d reconfigurable oxides
Climate change impacts on trees reproduction and forecasts of forest recruitment change (ForestFuture)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1482050.0
EU funding (EUR): 1482050.0
Participants: 1
Project status: SIGNED

The capacity of future forests to support biodiversity and deliver ecosystem services will depend on reproductive capacities that keep pace with 21st century climate change. The European continent is warming and drying out fast, and similar changes are happening word wide. The decade-scale trends in biodiversity will be governed by tree fecundity?the capacity of trees to produce seed and to disperse it to the habitats where populations can survive in the future. From the boreal to the tropical forests, including in majority of European tree species, reproduction happens through synchronized, quasi-periodic, non-stationary variation in fruit production, termed masting or mast seeding. Despite the crucial role of mast seeding in plant regeneration and wider ecological processes, our understanding of this process is rudimentary. Poor understanding of the mechanisms that govern it are challenges for anticipating alternations in forest reproduction and function. Reliable predictive models are consequently not available, and the unpredictable recruitment of trees has become a key obstacle to understanding forest change. Recruitment, including reproduction and dispersal, is the most undeveloped demographic process in Earth system models. This work will transform our understanding of mechanisms governing trees reproduction and deliver tools for predicting forest reproduction trajectories under climate change. The main outcomes will be the first experimental description of how masting emerge at proximal level, and how this is conserved among species. This will be also the first explicit test of how variation in masting patterns matters for forest regeneration trajectories. Together with analysis of global reproductive patterns, our work will deliver a step-change in identifying species and regions of special conservation care.
Technology for 3D fibrous eco materials (FibriTech)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Poland
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2024-12-31
Duration (months): 28.0
Total project cost (EUR): 3571428.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

We create eco fibrous-materials alternative to fossil-based materials. For the first time ever, we are adding 3rd dimension to paper- or textile-like materials. We bond 3D structures from cellulose fibres, while preserving environmentally-friendly properties given by nature. It allows to achieve 100% eco material with external shapes and internal densities which have not been possible yet. Our technology has been tested in eg. thermal/sound insulations, packaging, air filters. The aggregated market opportunity is +700 bn $. We would not replace all current products and some applications of plastics can be ecologically valid (post-recycling), but many of these markets need to find eco alternatives. A good example is use of lightweight cellulose 3D structures instead of difficult to recycle polystyrene in packaging. The first product-market fit is biodegradable growing media (soilless substrates) for plant cultivations, due to increase of investments in Vertical Farms in COVID times.