Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INTER-REGULATION OF CIRCADIAN AND AUTOPHAGIC PROCESSES IN STEM CELLS: IMPACT ON TISSUE REGENERATION AND AGING (CIRCautophAGING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Regeneration of skeletal muscle relies on its stem cells, also called satellite cells (SCs). These cells remain quiescent throughout their life, and only activate in response to injury to form new muscle fibers. The regenerative capacity of these cells declines with aging. In the past years, Pura Muñoz Cánoves’ lab showed that, with aging, quiescent SCs 1) lose basal autophagy and 2) reprogram their circadian transcriptome (including the autophagic transcriptome). The molecular bases of these processes, their potential interrelation and the consequences of their failure with aging, are unknown. Our integrating hypothesis is that active autophagy and circadian regulation are interconnected and required to preserve stem cell regenerative fitness throughout life. We aim to answer the following questions: Which is the relative contribution of the stem-cell-intrinsic versus the organismal clock to muscle regeneration during aging? Are circadian and autophagy processes interconnected? This is, does circadian clock disruption alter autophagy in SCs? Conversely, does autophagy disruption affect their circadian regulation? If so, does autophagy re-induction by nutritional regimes restore circadian and regenerative functions in aged SCs? Mice genetically-modified for depletion of 1) selected circadian clocks or 2) autophagy will allow us to assess the relative contribution and interrelation of autophagic and circadian machineries to muscle regeneration during aging. We expect that completion of this project will provide new fundamental knowledge on stem cell biology, regeneration and aging, which will open opportunities for stem cell rejuvenation.

Keywords: circadian clock,stem cells,muscle regeneration,autophagy
In vivo dynamics and plasticity of networks within CA3 of the hippocampus: effects of optogenetic stimulation and natural learning. (CA3RECURRENTPLASTIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-12-15
End date: 2018-12-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The CA3 subregion of the hippocampus is crucial for the formation of episodic memories on a short timescale, possibly due to synaptic plasticity in the recurrent connections between pyramidal cells. Previously, in vivo observations of these changes due to a learning event were elusive; however, in the current proposal we will use new methods to allow us to observe and manipulate the changes that occur in cells and synapses correlated with memory formation. To achieve this, we will combine optogenetic stimulation techniques with both intra- and extracellular in vivo electrophysiology to measure cellular properties, network dynamics, and both artificially- and naturally-induced synaptic plasticity. Additionally, we will restrict optogenetic expression to only those cells involved in the memory, allowing us to selectively identify and manipulate these cells. Stimulation of a subset of CA3 pyramidal cells while recording the intracellular trace from an individual CA3 pyramidal cell will provide the first insights into the nature of the recurrent network in vivo; incorporating stimulation protocols designed to induce synaptic plasticity will allow us to characterize different forms of plasticity in vivo. Adding stimulation of DG inputs to this protocol will allow us to measure the modulation of both activity and synaptic plasticity. Finally, we will test the effect of natural learning on the CA3 network, by recording extracellular activity in vivo, and taking measurements of cellular properties and synapse strength ex vivo. This project will allow us, for the first time, to link the single-synapse changes hypothesized to be crucial for memory with whole-animal learning.

Keywords: hippocampus,synaptic plasticity,fear conditioning,in vivo,electrophysiology,in vitro,mice,optogenetics,episodic memory,patch clamp,dentate gyrus
BIG DATA FOR SMART SOCIETY (GATE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Sweden,Bulgaria
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 387875.0
EU funding (EUR): 387875.0
Participants: 3
Project status: CLOSED

The general objective of GATE is to establish Centre of Excellence on “Big Data for Smart Society – GATE” that will fulfill the vision of Open Innovation through building a sustainable University-Government-Industry-Society ecosystem. The CoE will be established as joint initiative between Sofia University – the most prestigious educational and scientific hub in Bulgaria and Chalmers University of Technology, Sweden – leading European institution with extensive experience in research, education and innovation. CoE main research objective is to advance the state-of-the-art in the whole Big Data Value Chain, including development of advanced methods and tools for data collection from variety of structured and unstructured sources, data consistency checking and cleaning, data aggregation and linking, data processing, modeling and analysis, data delivery by providing both accessibility and proper visualization. Following challenges of the Programme Horizon 2020 and the Bulgarian Innovation Strategy for Smart Specialization 2014-2020, the project team selected the most promising Data Driven Innovation Pillars: Data Driven Government (Public Services based on Open Data); Data Driven Industry (Manufacturing and Production); Data Driven Society (Smart Cities); and Data Driven Science. The specific objectives of Teaming 1 phase are to establish a solid background for the creation and sustainability of a CoE at a national, regional and EU level through (1) Elaboration of a detailed and robust business plan with a long term vision for setting-up and sustaining of the CoE; (2) Strengthening the research capacity and potential in Big Data; (3) Establishment of an international collaborative network of Big Data and related fields researchers; (4) Increasing quality of education and training and offering measures for motivation and involvement of the next-generation Early-Stage Researchers; and (5) Wide dissemination and promotion of project aims, activities and expected outputs.

Keywords: centre of excellence,big data,big data infrastructure,data collection,data processing,modeling and analysis,data driven innovation,data driven society
An automated, machine learning, IoT agronomic platform for optimal irrigation, pesticide and fertilizer utilization at farms. (Revotree)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Revotree is an agronomic Internet of Things (IoT) automated intelligent irrigation platform that lets farmers know crops’ real needs, able to take autonomous decisions via its algorithms to control the opening and closure of the water flow, and simultaneously indicates the correct usage of pesticides and fertilizers without any user interaction, thereby improving crops’ productivity and natural resource usage. Revotree allows farmers to improve their business, saving up to 50% water (€ 2000/year per hectare) and improving the crop productivity by 20%. At the same time, Revotree allows to collect specific data on local crops and, through smart machine learning algorithms and AI, it can analyze, filter and tailor the data for each of its second level (big data) clients that will be agricultural research centers, agronomists, farm insurances, micro-local weather tracking, crops and farms mapping, pesticide and fertilizer companies. After the development process started in 2015 and the validation of the technology (9 installations in Italy and Switzerland), Revotree is ready to scale-up the technology thanks to the application in 300 fully operational farms in Southern Mediterranean countries, in order to validate the sensor manufacturing process and benefits for end-users. The market potentials are huge: only considering the already consolidated contacts with potential customers, the Serviceable and Obtainable Market (SOM) in the EU can be estimated to be 30 M€/year by 2024. During Phase 1 project, Revotree S.r.l. will develop a detailed technical and business feasibility analysis, focused on the supply chain optimization for Revotree’s hardware manufacturing, the prototypal Revotree’s process design, customers validation for subscription fee confirmation (300 €/year for farmer, 5000 €/year for big data customers), the analysis of the achievable market and the refinement of the Business Model to be implemented in the Market entry phase.

Keywords: iot for agriculture,smart irrigation platform,water saving
Seeding-Free, Non-INtrusive Aero-engine disToRtion meAsurements (SINATRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Switzerland,United Kingdom
Call: Non-intrusive, seedless measurement system: design, development, and testing (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 1486930.0
EU funding (EUR): 1486930.0
Participants: 4
Project status: SIGNED

For future, novel closely coupled airframe-engine architectures with BLI concepts, current testing technology struggles to accurately assess the inlet flow distortion levels that influence the engine stability due to the low spatial and temporal resolution of current experimental methods. New concepts will require support of numerical means, ground facilities as well as in-flight testing. Non-intrusive, laser-based solutions such as PIV or DGV require the inlet flow to be seeded, which comes with a number of caveats including the requirement of uniform seeding distribution across the measurement plane and the installation of seeding rakes within the intake sub-system. This is notably challenging in airborne measurements. A promising laser-based measuring technology is the seedless Filtered Rayleigh Scattering (FRS) which would be ideal for in-flight measurements. Due to its potential to offer spatial and temporal resolution similar to other laser methods, it allows even highly dynamic flow distortions generated by the geometry of the complex intakes to be clearly understood. SINATRA plans to further mature the FRS technology and provide the necessary outlook by achieving the following: a) Develop and validate up to TRL4 an FRS measuring system prototype, using a CW laser, for time averaged distortion measurements b) upgrade the above prototype, to demonstrate an FRS measuring system working with a pulsed laser thus showing the capability of the technology to measure instantaneous distortions on a unsteady flow up to TRL3, c) provide a ground test inlet distortion facility that will be available to the whole European aeronautical, industrial & scientific community enabling a wide range of non-intrusive flow measurements representative of future architectures to be explored simultaneously and d) use the distortion data from the FRS measurements to characterise the distorted flows that are pertinent to advanced propulsion systems by means of distortion descriptors.

Keywords: inlet flow distortion,non intrusive laser measurements,seeding free optical methods,total pressure distortion,swirl distortion,novel aircraft concepts,engine aircraft integration
Quantum and String Cosmology with Branes and Fluxes (BRANECOSMOLOGY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

This proposal promotes a research program in theoretical cosmology to be carried out by M. Schillo at the Institute of Theoretical Physics at K.U. Leuven. The aim of the research will be to address two of the pressing issues in modern cosmology: the lack of a reliable framework in which we can describe accelerating, vacuum dominated universes (such as our own), and the necessity for a theory of quantum gravity to describe the early universe. These problems have recently been impressed upon the cosmological community by the findings of the Planck satellite and the BICEP2 experiment, which provides ample motivation for the integration of high-energy physics and cosmology. Additionally, the fresh outlooks and theoretical models that this program is designed to produce will be necessary for the interpretation of findings of the next generation of ESA missions; without meaningful theories for the data to either support or falsify, the full potential of these missions cannot be realized. The innovative approach which will allow this research to contribute to the state-of-the-art in cosmology and move towards solutions to these problems is the combination of newly discovered dynamics and processes in string theory, which M. Schillo developed in her previous research, with the technologies of quantum cosmology and advanced string theory compactifications, in which the faculty of the high-energy group at K.U. Leuven are world-experts.

Keywords: quantum cosmology,string cosmology
Worm power: Can helminths modify the development of colorectal cancer? (WORMTUMORS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: South Africa,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 203200.2
EU funding (EUR): 203200.2
Participants: 2
Project status: CLOSED

The incidence of cancer is significantly lower in developing areas such as Africa, than in the Western world. These developing regions have a high incidence of helminth infection, which can protect against immune-mediated diseases and are currently being successfully used within clinical trials as novel therapeutics to treat inflammatory bowel disease. As Africa develops, lifestyle and dietary changes will collide with the presence of chronic infectious disease, such as gastrointestinal helminths, increasing the risk of colorectal cancer. The intrinsic immune-suppressive nature of helminth infections is known to be detrimental to the generation of immune responses to other infections and vaccination, and may also impair anti-tumor responses in vivo. We have recently found that local exposure to helminth products can result in increased tumor cell growth and metastasis. Currently, it is unknown how helminth modulation of immunity influences colorectal cancer incidence and progression. This fellowship proposal will make use of an inflammation-associated and spontaneous model of colorectal cancer to test the impact of live helminth infection and exposure to helminth excretory/secretory products on tumor development. It will further dissect the impact of helminth exposure on the innate and adaptive anti-tumor immune response, using multi-colour flow cytometry and cell-specific knockout mice. Furthermore, rescue of an impact of helminth exposure on anti-tumor immunity will be attempted by in vivo cell transfer. This fellowship aims to increase our understanding of how helminth infection contributes to tumor development and may lead to the design of novel therapeutics to improve tumor immunity.

Keywords: helminth therapy,colon cancer
Wielkopolska Researchers’ Night welcomes - Let the experience of the Night last every day! (EVERYDAYNIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-11-30
Duration (months): 19.0
Total project cost (EUR): 140347.5
EU funding (EUR): 133347.5
Participants: 6
Project status: CLOSED

Researchers’ Night again in Poznan! EVERYDAYNIGHT! Wielkopolska Researchers’ Night welcomes - Let the experience of the Night last every day! Come and see how research influences your every-day life! Reveal the interdisciplinary nature of science and learn how different scientific fields complement each other, making our life better. Join speed dating with our researchers, defeat them in quizzes and win a badge of the young scientist! See how future school will look like, reveal how environment interacts with robotics and sport. Meet MC fellows and convince yourself that career in science is a great adventure! Feel the atmosphere of NASA laboratory. Take part in “Mamma Mia” show - sing and dance with researchers, meet exoskeletons and discover the economics of joking. Feel like doing some sport? Come and play fitball, tennis or basketball with researchers. These and many other attractions are waiting for you to reveal your passion for science and convince you that researchers are just ordinary people with an extraordinary job and various hobbies. EVERYDAYNIGHT is a continuation of the Researchers’ Night projects of the past nine years, which were highly successful gathering in 2015 app. 59 000 participants. The project builds on last years’ experiences and aims at strengthening efforts to bringing researchers closer to the public at large, increase the awareness of research, by supporting the public recognition of researchers, clearly showing the impact of researchers’ work on society and every-day life. Activities during the Night on 30 September 2016 and 29 September 2017 will focus on public at large and will have hassle-free and festive character, being a valid alternative to "traditional Friday night activities". Those activities will offer a direct contact between researchers and public, combine fun elements (edutainment), envisage linking together Nights organised in different cities in Poland and ensure active involvement of both researchers and audience.

Keywords: researchers,poland,pozna,science and fun,edutainment
Global Encounters between China and Europe: Trade Networks, Consumption and Cultural Exchanges in Macau and Marseille (1680-1840) (GECEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: CLOSED

In the last decade the approaches of the global history have been emphasized in order to visualize the progress, form and method which historians have undertaken when carrying out ambitious research projects to analyse and compare diverse geographical and cultural areas of Asia and Europe. But when dealing with comparisons and cross-cultural studies in Europe and Asia, some scholarly works have exceeded of ambiguities when defining geographical units as well as chronology. In this project I examine perceptions and dialogues between China and Europe by analysing strategic geopolitical sites which fostered commerce, consumption and socioeconomic networks between China and Europe through a particular case study: Macau, connecting with South China, and Marseille in Mediterranean Europe. How did foreign merchant networks and trans-national communities of Macau and Marseille operate during the eighteenth century and contribute to somehow transfer respectively European and Chinese socio-cultural habits and forms in local population? What was the degree and channels of consumption of European goods in China and Chinese goods in Europe? These are the main questions to answer during my research to explore the bilateral Sino-European trade relations and how the trans-national dimension of exotic commodities changed tastes by creating a new type of global consumerism. Such concrete comparison can help to narrow the gap that some researchers have created when widely analysing differences between Asia and Europe without a specific geographical and chronological delineation. The major novelty of this project is based on the use of Chinese and European sources to study changes in consumer behaviour. The principal investigator of the project works in China which is and added value for the achievement of outstanding results. So the expected results will bring an obvious breakthrough by adding the specific part of the project in which each team member will work.

Keywords: global history,china,europe,consumer behaviour,trans national trade networks