Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Designing molecular rotations in solid electrolytes for high-performance batteries (RotoLyte)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-15
End date: 2024-10-14
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Electrolyte materials are at the core of many technologies linked to green and sustainable future development such as batteries, supercapacitors, fuel cells, electrochromic ‘smart’ windows, sea-water desalination, electrolytic hydrogen production. Research efforts in batteries have been focused on the dichotomy between the mutually exclusive advantages and disadvantages of solids vs. liquid electrolytes. Here, I propose an ambitious and innovative approach to achieve the best of both worlds through mesophasic, inorganic plastic crystal electrolytes, which feature solid-like macroscopic behavior but liquid-like local dynamics. A key feature of such plastic crystals is the rotational motion of the polyanions (e.g. sulfate, (thio-)phosphate) that is suspected to have a synergistic effect with the ionic migration ('paddle-wheel-' or 'rotating-door' effect) of small cations such as Li and Na that are key to the function of electrochemical devices. The goal of this project is to investigate this synergy between molecular rotations and ionic displacements at the atomic scale, with the goal of developing more performant solid electrolyte materials for applications such as next generation batteries. This is to be done by investigating the structure and dynamics of plastic crystals through combining my expertise in synthesis and diffraction with the host group’s expertise in NMR and DFT methodologies.

Keywords: plastic crystals,nmr,pair distribution function
On-board SYstems Relevant for hYbridization of Regional aircraftS (OSYRYS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: France,Ireland,United Kingdom,Germany,Italy,Belgium,Netherlands,Poland,United States
Call: Demonstration of On-board Systems relevant for hybridization of Regional aircraft (HORIZON-JU-Clean-Aviation-2025-01, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 56885170.75
EU funding (EUR): 39999998.93
Participants: 24
Project status: SIGNED

The achievement of the ACARE emission reduction targets, in combination with the projected growth in new aircraft deliveries, requires the aviation industry to do a further step, by drastically shifting towards electric/hybrid-electric propulsion also for larger aircraft, thus resulting into high electrical power distribution levels. The latter introduce new challenges in terms of electrical power generation & distribution, thermal management and energy management technologies to safely manage on board electrical power at these MW power levels. As a continuation of HECATE and TheMa4HERA projects, the OSYRYS consortium is uniquely positioned for the development and maturation of these technologies, targeting testing and integrated demonstration at TRL6 of electrical power generation & distribution solutions, thermal management solutions and avionics solutions for energy management relevant for future Ultra Efficient Hybrid Electric Regional Aircraft, in line with the objectives of REG-02 and the Clean Aviation SRIA. The OSYRYS consortium unites 14 industries of which 2 aircraft OEMs (ATR and AIRBUS), 5 SMEs and the others, including the coordinator, are industry leaders on aerospace electrical power generation and distribution system, but also thermal and avionics systems. This is complemented by 6 RTO institutions. 4 organizations are newcomers of which 2 are newcomers to aeronautics, providing spin-in from other industries or research fields. The participants are spread over 7 European countries. This ambitious 60-months programme, valued 55,5 MEuros for a grant request of 40 MEuros, will be implemented in tight relationship with REG-01, REG-03 and ACI-01 topics.

Keywords: hep,ultra efficient hybrid electric regional aircraft,thermal management,energy management,electrical power generation and distribution,high voltage
New Directions for Structure Segmentation, Phenotyping, and Language Interfacing in Histopathology (DeepSPIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1675683.0
EU funding (EUR): 1675683.0
Participants: 1
Project status: SIGNED

Progress in deep learning brings new tools and methods that start reshaping pathology practice and advancing research in oncology. As a postdoctoral researcher in the Mahmood Lab (Harvard Medical School, 2022–), I played a pivotal role in the development and evaluation of “foundation models” for pathology – general-purpose models that can be used for various downstream tasks. Despite advances, foundation models still face several key limitations that restrict their widespread adoption. First, these models are designed to provide “non-human interpretable” data representation, providing little actionable insights to practitioners. Moreover, they lack robust language interfacing capabilities, especially in providing quantitative information. Finally, they are predominantly focused on hematoxylin & eosin (H&E) staining, leaving other histopathology modalities largely untouched. In this context, I hypothesize that foundation models for pathology will remain limited in impact unless they incorporate key additional features: (a) off-the-shelf structure segmentation and phenotyping for downstream analysis, (b) interactive language interfacing capable of answering quantitative queries, and (c) expanded support for other modalities, e.g., immunohistochemistry. To bring these ideas to life, I introduce DeepSPIM. In DeepSPIM, I will semi-automate data labeling to train segmentation models that will be combined with large language modeling to build a language interface. I will evaluate the translational capabilities of the models in assisting pathologists with routine clinical tasks, and, exploring interpretable morphological correlates of treatment response in oncology. The goals of DeepSPIM are closely aligned with the technical skills I developed throughout my PhD and postdoc. Leveraging my mentoring experience, professional network, and support of the University of Lausanne and the ERC Program, I aim to establish an independent research group in computational pathology.

Keywords: computational pathology ai for pathology
TWIN-ON-A-CHIP BRAINS FOR MONITORING INDIVIDUAL SLEEP HABITS – HOP ON (NAP-Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Slovakia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 556625.0
EU funding (EUR): 556625.0
Participants: 2
Project status: SIGNED

The ongoing project NAP focuses on sleep disorders and proposes a novel science-to-technology paradigm to assess the ability of next generation brain organoids to serve as a downscaled and personalised model of sleep, as well as to predict early sleep-related symptoms of Parkinson’s Disease (PD). The integration of the widening partner STU provides the project with additional human data to the NAP Proof of Concept (i.e., the identification of the effects of sleep deprivation and detect sleep-related signs of D in a personalised perspective). Moreover, it brings to the further development of an innovative in-home sleep quality monitoring device, already available at STU as a prototype (the ePPG), to be integrated with SleepActa wearable actigraphic data already provided within NAP. The STU Laboratory of Medical and Applied Electronics is the main research laboratories in Slovakia dedicated to improving health care services by research in physiological monitoring, hardware processing, data evaluation and processing. NAP HOP-ON offers to the widening partners a new framework of collaboration with EU research institutions and EU SMEs covering a large spectrum of expertise (cellular neuroscience, bioengineering, biotechnology, micro-manufactured neural implants, sleep e-health) applied to sleep studies. This will increase the international visibility of the Laboratory. The NAP HOP-ON International Seminars and the International Mobility Programme is expected to contribute spreading the project approach, promote mutual enrichment among disciplines and support STU young researchers career development. On the medium long-term, more talented students and young researchers will be interested in developing a STU-based career, contributing to reversing the brain-drain at the country level. NAP HOP-ON also includes specific activities to strength STU staff know-how in EU R&I funding, increasing the partner competitiveness over international funding and a

Keywords: human sleep,non invasive human sleep monitoring,parkinson s disease,sleep alterations,signal processing
MAterials Genome engineering for re-Inventing CONcrete (MAGICON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2499407.0
EU funding (EUR): 2499407.0
Participants: 1
Project status: SIGNED

In MAGICON I propose a completely new philosophy for developing and designing concrete. I aim to conceptualize a strategy based on materials genome engineering that combines Experimental tools, Computational tools and Digital data. The MAGICON philosophy should make it possible to select and combine ingredients for concrete that result in optimized properties and behaviour. The need for reinventing concrete comes from the urge to use greener and more environmental friendly binder systems and alternative aggregate particles mainly from recycled materials to work towards a circular economy. The quality and, short and long term performance of concrete is governed by the interplay of binder and aggregates. Especially the connection between both, called Interfacial Transition Zone (ITZ), determines mechanical and transport properties of the composite. The ITZ is actually the finger print of the material and forms the basis in the MAGICON framework to redesign new concretes. To be able to characterize the ITZ and incorporate the results in the design philosophy the following challenges that never have been tried before should be overcome: (1) Develop a method to produce small scale samples including particles, matrix and ITZ which are representative for the composite, including its eigenstresses that are always present in all the phases. (2) Develop testing techniques for measuring mechanical and transport properties and the combined effect of mechanics and transport on the small scale samples. (3) Develop smart technologies for improving ITZ properties. (4) Understand, predict and tailor the results of the microscale testing by using deterministic models for upscaling. (5) Develop a strategy for creating data-sets from experiments, combined with smart numerical modelling that feed into ML systems for validating the behaviour of new sustainable concrete.

Keywords: concrete,sustainability,materials,performance
Bacteriophages as vehicles for antimicrobial resistance determinants: Do they represent an environmental risk? (PHASTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Although antibiotic resistance is a major and growing public health concern, surveillance for the expansion of this phenomenon in environmental settings has not been fully explored. However, recent studies suggest that antibiotic resistance found in clinical settings may emerge from environmental sources. In fact, the environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations, which may contribute to the emergence and spread of antibiotic resistance. It is therefore necessary to understand the mechanisms and factors that promote antibiotic resistance. The PHASTER project aims at exploring the presence, diversity, and abundance of bacteriophages in the environment. Particular points of interest will be the study of bacteriophages that lead to the mobilization of antibiotic resistance genes (ARGs) and their interaction with antibiotic compounds, even at extremely low concentrations, similar to those found in some aquatic environments. Mesocosm experiments will also be conducted to examine how bacterial communities respond to the presence of bacteriophages harbouring ARGs under stressful conditions, such as exposure to antibiotics. In order to reach these goals, a combination of metagenomics and bioinformatics approaches will be used to investigate the sources of ARGs, their environmental distribution and how anthropogenic inputs affect their spread. A better understanding of the mechanisms and factors that contribute to antibiotic resistance will permit the implementation of appropriate public health strategies, policies, and mitigation programs. Special attention will also be devoted to dissemination so that stakeholders and policy makers can benefit from PHASTER.

Keywords: horizontal gene transfer,bacteriophages,antibiotic resistance,anthropogenic pollution
AI Platform for Integrated Sustainable and Circular Manufacturing (Circular TwAIn)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS, Made in Europe (co-programmed)
Countries involved: Italy,Luxembourg,Greece,Spain,Türkiye,Switzerland,Norway,Germany,Serbia,Cyprus,Portugal
Call: Artificial Intelligence for sustainable, agile manufacturing (AI, Data and Robotics - Made in Europe Partnerships) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 7246095.0
EU funding (EUR): 5937356.0
Participants: 21
Project status: SIGNED

Circular TwAIn will lower the barriers for all the stakeholders in manufacturing and process industry circular value chains to adopt and fully leverage of trusted AI technologies, in ways that will enable end-to-end sustainability, i.e. from eco-friendly product design to the maximum exploitation of production waste across the circular chain. To this end, the project will research, develop, validate and exploit a novel AI platform for circular manufacturing value chains, which will support the development of interoperable circular twins for end-to-end sustainability. Circular TwAIn will unlock the innovation potential of a collaborative AI-based intelligence in production based on the use of cognitive digital twins. Moreover, based on the use of trustworthy AI techniques, Circular TwAIn will enable human centric sustainable manufacturing, fostering the transition towards Industry 5.0. Furthermore, Circular TwAIn will enable the integration and combination of different data from various sources over entire product life cycle considering sustainability aspects. The goal is to create and deliver innovative services among the members of the data ecosystem; these services will be embedded in AI-based Digital Twins, supporting an unambiguous communication when realizing complex services for sustainable manufacturing. The ambition of Circular TwAIn is to unleash the sustainability potential of AI technologies in circular manufacturing chains through: (i) Introducing AI optimizations in stages where AI is still not used (e.g., AI-based product design); (ii) Using AI for multi-stage and multi-objective circular optimizations that could improve sustainability performance. In this direction, the project will leverage information from a circular manufacturing dataspace that will provide access to the datasets needed for multi-stage and multi-objective optimizations.

Keywords: circular manufacturing,lifelong circular and sustainable value chains,data spaces for manufacturing,ai based sustainable production,ai based digital twins for sustainable manufacturing
More Is Different: Addressing Subradiance Generation in Ordered Linear Dysprosium arrays (MIDAS GOLD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Understanding the light-matter interaction at the quantum level is crucial for numerous applications ranging from quantum metrology to quantum computing and quantum communication. While the interaction of light with a single quantum emitter is well understood, an ensemble of many emitters coupled by a resonant probe is a complex open quantum many-body system. The collective spontaneous emission can be substantially enhanced (superradiance) or suppressed (subradiance), compared to the single emitter case. Subradiant states are particularly intriguing because they constitute an effective storage medium for light, hence for quantum information, and have been indeed proposed as useful tools for quantum communication protocols. Nevertheless, the experimental study of subradiance has been restricted to a few works, in which at most a few percent of the excitations were stored in subradiant modes, resulting in small amplitude signals. The MIDAS GOLD project aims to address the generation of subradiant states in ordered arrays of atoms, with a control at the single-atom level. The action will take place in a running, state-of-the-art experimental system producing ordered arrays of dysprosium atoms in optical tweezers. First, we will implement an original and innovative protocol to controllably generate subradiant states with 2 atoms confined in the same optical tweezer, a first proof of principle demonstration of a bottom-up approach to subradiance. Then, we will prepare arrays of many atoms with subwavelength separations by building an accordion optical lattice, and we will explore protocols to control the storage and release of excitations in subradiant modes of the array. The accomplishment of MIDAS GOLD's objectives and the key upgrades to the existing apparatus will deepen the knowledge of subradiance, paving the way for future applications, and will build up a cutting-edge experimental system for the more general problem of collective light scattering.

Keywords: collective light matter interactions subradiance optical tweezers
Protein ER-ways: assembling ER-translocons on-the fly (Protein ER-ways)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

The human proteome is primarily synthesized at the endoplasmic reticulum (ER) membrane through the ribosome-translocon complex. This assembly is crucial for protein synthesis, translocation, membrane insertion and post-translational modification. Depending on the type of protein being synthesized, the translocon adopts either a secretory (soluble proteins) or multipass (membrane proteins) form. Newly synthesized proteins often carry a signal peptide that is cleaved by the signal peptidase complex (SPC) co-translationally, indicating possible structural interactions between the ribosome-translocon complex and the SPC during this process. In the proposed project, I aim to elucidate these interactions and explore how different translocon variant recruitment affects polysome topology, as well as reveal the structural interactions between the ribosome-translocon complex and the SPC during signal-peptide cleavage in high-resolution. I will carry out the project in three phases. First, I will develop a multimodal mRNA probe to detect ribosome-translocon-SPC complexes, enabling their visualization during protein synthesis. In the second phase I will investigate how different translocon variants affect polysome topology using advanced imaging techniques such as cryo-correlative light electron microscopy (cryo-CLEM) and cryo-electron tomography (cryo-ET) ex vivo. These methods will help identify how polysome topology is affected by recruitment of specific translocon variants interact at the ER membrane. Finally, I will use single-particle cryo-electron microscopy (SPA cryo-EM) to achieve a high-resolution reconstruction of the ribosome-translocon-SPC complex, providing detailed insights into the molecular interactions during nascent polypeptide synthesis and signal peptide cleavage. This research outcomes of the proposed project will significantly advance our understanding of ER protein biogenesis and its regulatory mechanisms.

Keywords: endoplasmic reticulum,ribosome translocon complex,signal peptidase complex,cryogenic electron microscopy