Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoengineered Nanoparticles and Quantum Dots for Sensor and Machinery Applications (NANOSENSOMACH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Israel
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-01-01
End date: 2016-12-31
Duration (months): 72.0
Total project cost (EUR): 2167400.0
EU funding (EUR): 2167400.0
Participants: 1
Project status: CLOSED

Chemically modified metallic nanoparticles (NPs) or semiconductor quantum dots (QDs) are central components for the future development of nanotechnology and nanobiotechnology. This program aims to introduce new dimensions into the field of nanotechnology and nanobiotechnology by synthesizing, characterizing and assembling molecule- or biomolecule-modified nanoparticles (NPs)/Quantum dots (QDs) hybrid nanostructures that perform tailored and programmable functionalities. The project will include two complementary research activities. One direction will include the generation of electropolymerized ligand-functionalized Au NPs matrices on electrode surfaces. By tethering of appropriate ligands to the NPs, imprinted matrices for selective sensing, and signal-triggered NPs "sponges" for the selective uptake and release of substrates will be designed. Also, electrochemically induced pH changes by the NPs matrices will be used to control chemical reactivity (e.g., sol-gel transitions, activation of the ATP synthase machinery). The second research direction will implement ligand-modified QDs for the sensing of ions or molecular substrates. Similarly, nucleic acid-functionalized QDs will be used to develop new versatile sensing platforms exhibiting multiplexed analysis capabilities. One platform will include the quenching of the QDs by G-quadruplexes, whereas the second platform will use biochemiluminescence resonance energy transfer (BRET) as readout signal. Also, QDs-modified supramolecular DNA nanostructures will be designed to perform programmed machinery functions such as "bi-pedal walker", "seesaw", "gear" or "tweezers", and the machinery functions will be transduced by the optical properties of the QDs. Finally, DNA-machines that trigger the isothermal amplified replication of the analyzed nucleic acid will be designed, and QDs tethered to the machine will optically transduce the replication process at real-time.

Keywords: dna machines,nanobiotechnology,biosensors,quantum dots: molecular imprinting
Ultrasmall Chemical Imaging of Cells and Vesicular Release (NANOCELLIMAGE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Sweden
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 2491881.0
EU funding (EUR): 2491881.0
Participants: 2
Project status: CLOSED

The long-term goal of this research is to establish the chain of molecular events associated with (1) neurotransmitter release at the single cell and subcellular level and (2) with cell differentiation and reprogramming. These are incredibly important goals for which there are few analytical chemistry methods that are available and useful. The immediate goal therefore includes development of three chemical methodologies at the cutting edge of analytical chemistry: 1) the development of arrays of nanometer electrodes that can be used to spatially measure the release of easily oxidized substances across the cell surface; 2) to improve the combination of MALDI and cluster SIMS ion sources on an orthogonal QStar instrument to enable protein and glycoprotein analysis at the single whole cell level, lipid domain analysis at the subcellular level, and importantly, depth profiling; and 3) the application of information discovered at single cells and of the methods developed in goals 1 and 2 to an in vitro model of cell-to-cell communication and regeneration. I intend to build on my expertise in both electrochemistry and SIMS imaging to develop these approaches. The work described here constitutes two new directions of research in my group as well as new analytical chemistry, and, if successful, will lead to researchers being able to gather incredibly important new data about cell-to-cell communication and cell differentiation and reprogramming as well as to a better understanding the role of lipids in exocytosis and endocytosis.

Keywords: chemical imaging exocytosis stem cells
Quantitative Reactive Modeling (QUAREM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Austria
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 2326101.0
EU funding (EUR): 2326101.0
Participants: 1
Project status: CLOSED

The project aims to build and evaluate a theory of quantitative fitness measures for reactive models. Such a theory must strive to obtain quantitative generalizations of the paradigms that have been success stories in qualitative reactive modeling, such as compositionality, property-preserving abstraction, model checking, and synthesis. The theory will be evaluated not only in the context of hardware and software engineering, but also in the context of systems biology. In particular, we hope to use the quantitative reactive models and fitness measures developed in this project for testing hypotheses about the mechanisms behind data from biological experiments.

Keywords: formal verification model checking concurrency theory
Large-Scale Demonstration of Advanced Smart GRID Solutions with wide Replication and Scalability Potential for EUROPE (GRID4EU)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: France,Germany,Germany,Sweden,Spain,Czechia,Czechia,France,Germany,Netherlands,Germany,Spain,Italy,Belgium,United States,Spain,Switzerland
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-11-01
End date: 2016-01-31
Duration (months): 51.0
Total project cost (EUR): 49994437.89
EU funding (EUR): 25090728.59
Participants: 29
Project status: CLOSED

Grid4EU project is an innovative SmartGrid project proposed by a group of Distribution System Operators (from Czech Republic, France, Germany, Italy, Spain and Sweden), in close partnership with a set of electricity retailers, manufacturers and research organizations. Adopting a systemic approach and organized around large-scale demonstrations networks located in six different countries, its structure is built to facilitate dynamic knowledge sharing, technical assistance and review. The project will run over a 51 month period. Grid4EU aims at testing in real size some innovative system concepts and technologies in order to highlight and help to remove some of the barriers to the smart grids deployment and the achievement of the 2020 European goals. These barriers may be technical, economic, societal, environmental or regulatory barriers. It focuses on how distribution system operators can dynamically manage electricity supply and demand, which is crucial for integration of large amounts of renewable energy, and empowers consumers to become active participants in their energy choices. Ultimately, these innovative concepts and technologies should cost-effectively increase the network’s reliability, flexibility, and resiliency.

Keywords: grid4eu
BIOfuel From Algae Technologies (BIOFAT)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: Portugal,Italy,Spain,Israel,France,Netherlands,United States,Italy
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 9985182.84
EU funding (EUR): 7773133.4
Participants: 11
Project status: CLOSED

BIOFAT is a ‘microalgae to biofuel’ Demonstration project with a farming area of 10-ha for microalgae cultivation and a target annual productivity of 100 tons per ha. The project will integrate all the processes from single cell to biofuel production. The production stage will be based on photobioreactors for inocula production, and raceways for production of bulk biomass and induction of oil/starch accumulation, necessary to obtain the biofuel (biodiesel and bioethanol). Carbon dioxide derived from fermentation will be used. Biomass harvesting will be done by pre-concentration and subsequent centrifugation. A low-energy input centrifuge will be used. Extraction will be done by mechanical cell disruption of wet (25-30% dry solids) paste. Oil will be transformed into biodiesel by transesterification, and carbohydrates to bioethanol through fermentation. Oil and carbohydrate accumulation will be obtained by nutrient stress using specific algal strains. Only marine strains will be used to avoid any competition with food crops. BIOFAT will also develop the concept of algorefinery (i.e., high value co-products besides biofuels). BIOFAT will demonstrate at 10-ha scale proven and tested technologies which have been developed by Consortium members at small scale. Innovation will be in the scaling-up of the process to the 10-ha Demo Plant. Specific Engineering and Business Plans for setting up the 10-ha Demo Plant will be based on the results obtained from operation of 2 0,5 ha Pilot Plants (Italy and Portugal). The 2 prototypes existing in Israel and Italy will be used for the training of a development team. The overall sustainability of the algal biofuel and co-products production will be evaluated by LCA. The project will have a duration of 5 years. A funding of 7,733 K€ will be requested to the EC. A specific investment for the Demo Plant will be provided by investors according to the Business Plan developed by the Consortium and by mobilizing the necessary investment support from RSFF.

Keywords: microalgae,biofuels,lca,sustainability,non-fossil co2,scale-up,demo plant,industrial
Aspects of G2 Geometry (G2 GEOMETRY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2013-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

A first objective of this proposal is to construct large numbers of new G2 manifolds by extending Kovalev's ``connect sum" construction to a larger class of 3-folds. This will be achieved via a combination of differential, algebraic and analytic methods which will lead to a very good understanding of the topology of these manifolds, of the relationship to the geometry of the generating 3-folds, and of the limits of the ``connect sum" construction. A second objective is to construct new examples of associative submanifolds, partly using the above results, and to study moduli spaces of associative submanifolds with respect to various notions of ``tame" G2 structures. A third objective is to construct holomorphic 3-folds with trivial canonical class starting from integral affine manifolds.

Keywords: exceptional holonomy,g2 manifolds,calibrated submanifolds.
Destabilization of the Epithelial Tissue Architecture by Competition with e-cadherin Homo-dimer formation: small molecule-induced disruption of the epithelium integrity and functions (DETACH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cadherin expression on the surface of cells is critical for cell-cell adhesion and, consequently, for the development and the integrity of solid tissues. In mammals, impaired cadherin mediated adhesion has been implicated in all steps of tumor progression. E-cadherin, a prominent member of the cadherin family, is expressed on the surface of epithelial cells in the digestive tract, in the lungs as well as in the testis and other organs and is therefore responsible for the integrity of the mucosal tissues that protect a vast surface of the inner body. Cell adhesion mediated by E-cadherin and other type I cadherins involves homophilic “trans” interactions that are brought about by a strand exchange mechanism involving the N-terminal extracellular domain. The epithelial tissue constitutes the body’s first line of defense and, as such, is exposed to a large number of small, potentially toxic molecules from the environment whose chemical and structural features are reminiscent of the tryptophan residue (Trp2) used by E-cadherin in its dimerization mechanism. These molecules can mimic the Trp2 function in E-cadherin by inserting into the hydrophobic acceptor pocket of E-cadherin and by occuping the site of Trp2 docking, thus potentially interfering with the E-cadherin mechanism of self-adhesion. We hypothesize that such events can disrupt the integrity of the epithelial tissue, ultimately causing tissue remodeling and the loss of the epithelium’s protective properties. The main aim of this project is to use X-ray crystallographic analysis to determine whether a number of known environmental pollutants that are present in the atmosphere as well as in foods or other media to which the population is commonly exposed can bind into or in the vicinity of the E-cadherin hydrophobic pocket or cause structural changes that prevent E-cadherin dimerization, thus causing disruption in the integrity of the body’s first line of defense.

Keywords: e-cadherin dimerization,environmental pollutants,e-cadherin structure,tissue remodelling
When Battlefield Success Leads to Effective Counterinsurgency: Searching for a Cross-Regional Theory (COINTRPE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

As the frequency of interstate wars is decreasing and violent non-state actors’ challenge to states is becoming more common, the subject of counterinsurgency is increasing in prominence for scholars and policy makers both in Europe and in other parts of the world. Especially the current counterinsurgency campaigns in Iraq and Afghanistan, as well as increasing references to Al Qaeda as a global insurgency have contributed to the growing importance of counterinsurgency. This research asks the question why sometimes battlefield success against the insurgents leads to an overall success in counterinsurgency and brings an end to the internal conflict, while other times it fails to achieve this outcome. Although states tend to resort to coercive (i.e., military) methods in order to eliminate insurgencies, these methods, in fact, have a mixed record of success. Even when states seem to inflict significant damage on the insurgents militarily, this does not necessarily bring an overall success in counterinsurgency. In light of a comparative case study of Turkey and Peru and the analysis of a number of additional cases, this research aims to identify ways in which states can most effectively deal with insurgent organizations and end conflict and violence within their borders. It proposes that in order to eliminate an insurgency, it is more important to find the best method that directly responds to the characteristics, goals, and external connections of the particular insurgent organization challenging the state than to focus on various military, economic, social, and cultural methods based on their generic advantages and disadvantages.

Keywords: political sciences,counterinsurgency,counterterrorism,low-intensity conflicts
RUTHENIUM AND OSMIUM CLUSTER COMPLEXES DERIVED FROM N-HETEROCYCLIC SILYLENES, GERMYLENES AND STANNYLENES (POLYRUOSSIGESNYLENES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The purpose of this project is to extend the chemistry of ruthenium and osmium clusters derived from N-heterocyclic carbenes (NHC) to the silicon, germanium and tin analogues (NHM, M = Si, Ge, Sn). The interest of this proposal is based on: (a) the absence of this kind of polymetallic compounds, (b) the interesting Ru3-NHC and Os3-NHC chemistry reported recently by Cabeza, Whittlesey, Cooke and Cole, amongst others, which cannot be replicated by mononuclear derivatives, and (c) the fact that Ru-NHC complexes are among the most active catalysts for key reactions in organic syntheses; for example olefin metathesis (including ring opening and closing processes) and a battery of cross-coupling reactions (Heck, Suzuki, Sonogashira, Stille and Kumada). The project will be divided in two main parts: (A) Stoichiometric reactions, including studies on: (i) the synthesis and characterisation of new Ru-NHM and Os-NHM cluster complexes, (ii) the ability of NHM ligands to promote intramolecular C–H, C–C, C–N, Si–N, Ge–N and Sn–N bond activations, (iii) the reactivity of the aforementioned derivatives toward unsaturated organic substrates, aiming C–C, C–N and M–heteroatom coupling reactions to form novel functionalised organic molecules, and (iv) theoretical calculations (DFT) to rationalize the transformations observed; and (B) Catalytic processes (olefin metathesis and coupling reactions) using the complexes outlined in part A or modified systems containing hemilabile ligands, able to promote the necessary coordination vacancies onto which the organic substrates can be fixed and transformed. This work will be developed in Cabeza´s Organometallic Cluster group (University of Oviedo-Spain), which its great experience in the area of ruthenium and osmium carbonyl clusters (derived from N-donor and NHC ligands), along with the promising possibilities that the fusion of NHM ligands and polymetallic compounds offer, provides all the necessary ingredients for a successful project.
Interactions between G-protein Coupled Receptors and Ligand Gated Ion Channels (GPCR-LGIC COUPLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Dopamine receptors are members of G-protein coupled receptor superfamily. These receptors are the key point of dopaminergic system, which controls the regulation of memory, attention, food intake, endocrine regulation, psychomotor activity and positive reinforcement. To regulate so many critically important neurological events, dopamine receptors have complex interactions with other receptors and ion channels. In this study, a trimeric complex comprising D2 receptor -which is a subtype of dopamine receptors- , A2A adenosine receptor being another G-protein coupled receptor and a ligand gated ion channel N-methyl-D-aspartate (NMDA) receptor will be investigated. The aim of this project will be the application of a novel technique we refer as SplitGFP-FRET for the first time. For this study, “Fluorescence Resonance Energy Transfer” and “Split GFP” methods will be combined so as to reveal the trimeric D2 dopamine receptor- A2A adenosine receptor-NMDA receptor interactions. With the proposed study, a fluorescence technique to analyze live cell culture will be developed. This model will potentially lead to understanding of molecular mechanisms of many neuropathological conditions like schizophrenia and Parkinson’s disease because these disorders have already been shown to be associated with dysregulations in dopaminergic systems. Therefore, this project aims to reveal detailed links between schizophrenia and interactions of D2 dopamine receptor with other receptors and ion channels. The developed live cell model will also be useful for testing anti-psychotic drugs whether they have effects on disruption of protein-protein interactions, which will, in turn, ease screening of newly designed drugs.

Keywords: gpcrs,lgic,nmda,dopamin d2,fret,split gfp,membrane proteins,protein-protein interaction,neurobiology
Targeting endothelial metabolism: a novel anti-angiogenic therapy (ECMETABOLISM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Belgium
Call:  (ERC-2010-AdG_20100317, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 2365224.0
EU funding (EUR): 2365224.0
Participants: 1
Project status: CLOSED

Current anti-angiogenesis based anti-tumor therapy relies on starving tumors by blocking their vascular supply via inhibition of growth factors. However, limitations such as resistance and toxicity, mandate conceptually distinct approaches. We will explore an entirely novel and long-overlooked strategy to discover additional anti-angiogenic candidates, based on the following innovative concept: ¿rather than STARVING TUMORS BY BLOCKING THEIR VASCULAR SUPPLY, we intend TO STARVE BLOOD VESSELS BY BLOCKING THEIR METABOLIC ENERGY SUPPLY¿, so that new vessels cannot form and nourish the growing tumor. This project is a completely new research avenue in our group, but we expect that it will offer refreshing long-term research and translational opportunities for the field. Because so little is known on endothelial cell (EC) metabolism, we will (i) via a multi-disciplinary systems-biology approach of transcriptomics, proteomics, computational network modeling, metabolomics and flux-omics, draw an endothelio-metabolic map in angiogenesis. This will allow us to identify metabolic regulators of angiogenesis, which will be further validated and characterized in (ii) loss and gain-of-function studies in various angiogenesis models in vitro and (iii) in vivo in zebrafish (knockdown; zinc finger nuclease mediated knockout), providing prescreen data to select the most promising candidates. (iv) EC-specific down-regulation (miR RNAi) or knockout studies of selected candidates in mice will confirm their relevance for angiogenic phenotypes in a preclinical model; and ultimately (v) a translational study evaluating EC metabolism-targeted anti-angiogenic strategies (pharmacological inhibitors, antibodies, small molecular compounds) will be performed in tumor models in the mouse.

Keywords: angiogenesis,endothelial cell,cancer therapy,transgenic animal models