Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unlocking the methane cycling archives from Arctic lakes: a biological fingerprint (ArCH4ives)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-12-02
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Arctic landmasses and lakes release significant amounts of methane (CH4), a potent greenhouse gas that contributes to global climate change. Yet, the effect of rapid warming in the Arctic on the fate of CH4 emissions is poorly understood, particularly over decadal to millennial timescales. The recent advance of high-throughput sequencing and metabarcoding techniques to analyse ancient environmental DNA, or paleogenomics, from Arctic lake sediment has tremendously heightened analytical sensitivity and thus unlocked a wealth of new information on past ecosystems and their processes. I will combine this innovative approach to a robust paleoecological framework and multivariate analyses to study the drivers underpinning microbial assemblages involved in the cycling of CH4 during major periods of climate variability in Greenland since deglaciation. By using an important multi-site set of lake sediment cores spreading along major environmental gradients and collected by the Anthropocene-Quaternary Research Group, I will upscale the study from catchment to region and from the present Anthropocene (~last 150 years) to the early deglaciation of the Holocene (~11,700 years ago). This dataset will also enable me to control for the different catchment-specific processes that may have influenced microbial abundance, diversity and function in the past, and isolate the influence of climate on their ecology. This interdisciplinary approach will be supported by the analysis of additional paleoecological proxies for other important components of the carbon cycle in Arctic watersheds via collaborations with Canadian and Australian laboratories. While acquiring new expertise in cutting-edge paleogenomics and microbial ecology in world-leading research facilities at the Centre for GeoGenetics, I will advance paleoecology, gain significant new insights into the global carbon cycle and improve our understanding of the sensitivity of polar ecosystems.

Keywords: paleogeonomics,edna,sediment,holocene,carbon cycle,microbial ecology
Study of the distribution of gluons and quarks inside the nucleon through ultra-peripheral collisions (pANUCSTR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The proposed research will provide a deeper understanding of the internal structure of the nucleon by studying ultra-peripheral collisions (UPCs) of protons and ions using data collected by the LHCb experiment at the Large Hadron Collider at CERN. The structure will be probed by measuring the cross sections of (i) time-like Compton scattering, (ii) exclusive diffractive production of J/ψ mesons, (iii) pairs of mesons containing charm or bottom quarks and (iv) dijet production in proton-lead UPCs. The first two processes probe gluon and quark generalized parton distributions, which describe the distribution of quarks and gluons inside the nucleon or heavy ion as a function of their longitudinal momentum fraction and their transverse position. The last two processes offer access to Wigner distributions, which in addition are sensitive to transverse momentum. The processes are also sensitive to saturation phenomena.

Keywords: nucleon structure generalized parton distributions and wigner distributions,saturation,ultra peripheral collisions
NUADA: YOUR LIFE. HANDS-ON. (NUADA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hand and wrist Musculo-skeletal Disorders, largely originated by pathologies such as arthritis or stroke, are more and more frequent. There are around 107,5M people reportedly suffering from any type of hand-related MSDs in the EU and the USA and the number is expected to grow by nearly 50% until 2030. This type of disease is cause of huge limitations and pain and a strong negative influence in the patients quality of life. NUADA was founded in 2014 to solve this problem by bringing to market an award-winning patent-pending glove that prevents and compensates manipulation disabilities. The gloves beyond state-of-the-art technology is composed by special built-in bioinspired artificial tendons that support the hand when functionally required and are connected to a patented system that is worn on the users’ wrist. In addition to the hand function support, the NUADA glove is equipped with tracking components that collect users’ metrics and shares the data with the user and/or healthcare professionals. We have successfully raised over 600k€ of funding and nearly 1M€ in public funding for R&D, having obtained recognition by some of the world’s most relevant innovation awards and accelerators such as the Microsoft Imagine Cup, the HAX accelerator and TechCrunch. Due to the immense variety of potential applications for our technology we have defined labour related injury prevention as our beachhead market (i.e. in the manufacturing and retail sectors) while simultaneous aiming for an entry in the more regulated, but highly promising, healthcare market. NUADA’s customers get a more intelligent, more capable, user-friendly, seamlessly wearable glove for about one quarter of the price of the most competitive alternative. The successful market entry of the NUADA glove will mean injury prevention, fatigue relief, increased job safety and hand mobility, in sum, a better health and life quality for its users.

Keywords: cyber physical system,exosqueletics,musculoskeletal,disorder,arthritis,rheumatoid,ageing,elderly,well being,health,occupational,glove,smart
Using Deep Learning to understand RNA Binding Protein binding characteristics (DEEPLEARNRBP)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-07-01
End date: 2022-05-09
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

New technologies have revolutionized our understanding of RNA binding protein (RBP) function. Global screens for RBPs have pulled down hundreds of proteins for which no discernable RNA Binding Domain is present. These proteins, termed enigmRBPs due to their enigmatic nature, do bind RNA in unknown and variable fashion. An ever increasing number of such RBPs are having their target sites identified via CrossLinking and ImmunoPrecipitation Sequencing techniques (CLIP-Seq). This torrent of data can be harnessed by novel Deep Learning techniques to identify high order characteristics of RBP function. The aim of this proposal is the development of a machine learning model that can explore the functional implications of RBP binding characteristics. A model that, given an enigmatic RBP, can identify other known RBPs that show similar binding characteristics, such as sequence motifs, conservation motifs, secondary structure motifs, and higher order combinations of the above. We will focus on methods to practically interpret the machine learning model to biological knowledge, especially higher order filters that can learn the interplay among varied input, such as secondary structure, sequence and conservation. Beyond the theoretical, we will disseminate our methods in easy to use, standalone and web application format, in order to increase the practical application of our research. We are transplanting expertise from the bioinformatics and machine learning field, into a fertile substrate of RNA biology and CLIP-Seq experimentation. This interdisciplinary project will involve close collaboration and two-way transfer of knowledge in a dynamic research environment.

Keywords: rna binding proteins,clip seq,deep learning
Utilizing Urban Tech to Power Smarter Cities (Geme.io)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Estonia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

While smart cities initially focused on connecting infrastructure for better insights, the spotlight is slowly shifting to e-government. Cities are providing data to end-users to drive better decision-making. They tap into the collective intelligence of their constituents to create solutions around some of the toughest urban problems. Armed with the right data and tools, citizens can become more proactive, connected, collaborative, and participative in the smart city movement, and businesses can raise productivity and thereby the competitiveness of their City. Geme.io is a single and the one and only scalable app solution in which users (consumers, citizens, businesses, government officials), can filter for relevant, timely location-based information according to preference. Users can create their own information that is timely surrounding their current location on a virtual map, no matter the location, geared at everything that they need or want to know. In order to reap the benefits of e-government of more efficiency, savings, transparency and participation, Geme.io - a proximity and location-based urban tech app platform - can play an important role, e.g. with integration of voice assistants, wearables, sensors and a City’s cloud application. Download of the app is free of charge for anybody and one can find location-based relevant information and manually create own location markers -Gemies. We will charge a monthly subscription fee for our services; organizations, businesses and cities will pay to find reports with relevant location-based information or pay for a customized interface, or use our APIs to automate dissemination of information. Our management team consists of three Danes living in different cities that face different challenges. One of us has a child in a wheelchair, one had a family member living in a highly air polluted city and suffering from cancer and one of us is passionate about empowering and engaging citizens in their local community.

Keywords: open information,geolocation app,social media,e government,crowdsourced data,community building
Ultracold mercury for a measurement of the EDM (quMercury)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1939263.0
EU funding (EUR): 1939263.0
Participants: 1
Project status: SIGNED

The Standard Model of particle physics (SM), while largely successful, fails to accurately describe the state of the Universe, e.g. with respect to the evident matter/antimatter asymmetry. Various theories seek to conciliate the SM with observations by extending it, and most of these extensions introduce a massive violation of the combined charge invariance and parity (CP) symmetry. The CP violation would reflect in a sizeable permanent electric dipole moment (EDM) of fundamental particles, large enough to be detected by realistic future experiments. A few pioneering experiments already set out to measure the EDM of neutrons, electrons, or atoms. The most stringent upper limit to any EDM is currently obtained by an experiment based on room-temperature gases of mercury. I propose to take this approach to the quantum world by employing ultracold or even quantum-degenerate mercury samples. To this end, we will construct a dedicated quantum gas experiment. We will develop advanced cooling methods, obtain the world’s first Bose-Einstein condensate and degenerate Fermi gas of mercury, and introduce vacuum ultraviolet (VUV) lasers to the field. These ground-breaking innovations will increase the coherence time of the sample, enable a higher detection efficiency, and exploit coherent effects, thereby increasing the sensitivity tremendously. Our measurements of the Hg-199 atomic EDM will complement cold-molecule measurements of the electron's EDM. Technologies developed here can readily be utilized to improve the performance of Hg lattice clocks and will inspire quantum simulations of unique many-body systems. The principal investigator of this project is highly respected for his pioneering work on degenerate quantum gases of strontium. His current work on a nuclear optical clock introduced him to VUV optics and strengthened his footing in the community. Bringing together his expertise in these two fields – quantum gases and VUV optics – will lead the project to success.
Correlated Non-Equilibrium Quantum Matter: Fundamentals and Applications to Nanoscale Systems (Corr-NEQM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1495478.0
EU funding (EUR): 1495478.0
Participants: 1
Project status: SIGNED

Non-equilibrium states of matter occur in a wide range of systems. From microscopic scales of atoms and electrons to stars and galaxies in the universe. These phenomena have observable effects measurable by humans. In many of these systems the laws of thermodynamics do not apply. In spite of the ubiquity of non-equilibrium states, their universal understanding is still rudimentary. A general description of out of equilibrium states is of fundamental importance and can potentially spur technological innovation. Therefore, non-equilibrium systems host a family of questions which can be a source of knowledge and benefit to humankind. In this proposal I will tackle several open problems on correlated non-equilibrium quantum states in condensed matter physics. The remarkable twin discoveries of many-body localization (MBL) and time crystals have opened a new paradigm for non-equilibrium matter where an interacting quantum system violates the laws of equilibrium thermodynamics. By amalgamating tools and ideas from quantum information science, I will theoretically investigate these phenomena in regimes which are thus far unexplored. It will shed new light on MBL in higher dimensions and effect of long range interactions, a common feature in many physical systems. I will explicate the formation of discrete time crystals, a new phase of matter with broken time-translational symmetry, in dissipative systems. Until recently, MBL was considered to be an essential ingredient for time-crystallinity. The project will unravel the underlying principles of dissipative time crystals and the crossover from their semi-classical realization to the purely quantum effect protected by MBL. I will also predict smoking-gun signatures of these phenomena which are testable in semiconductor nanostructures. An answer to these vital questions will provide a deeper understanding of fundamental physics and may open new avenues for spatio-temporal control of entanglement in many-body quantum states.

Keywords: many body localization,discrete time crystals,semiconductor nanostructures
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications (COSY-BIO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Switzerland,France,France,United Kingdom,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 2996856.25
EU funding (EUR): 2975345.0
Participants: 10
Project status: CLOSED

Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet because of the complexity of engineering biological systems where basic biological parts are intrinsically noisy and not modular. The overarching goal of COSY-BIO is to develop a theoretical framework and innovative technological tools to engineer reliable biological systems that are robust despite their individual components being not by translating principles of control engineering to molecular and cell biology. Automatic control is a well-established engineering discipline to build “controllers” to steer the dynamic behaviour of a physical system in a desired fashion. By building upon control engineering for physical systems and by exploiting the unique features of living organisms, this project will identify generally applicable approaches to design closed-loop feedback controllers for biological systems. To handle biological complexity, the project will explore three strategies of increasing difficulty “external” controllers, “embedded” controllers and “multi-cellular” controllers. External controllers will be implemented in a computer acting on cells using small molecules via microfluidics devices. Embedded controllers will be made from biological parts and integrated within individual cells to steer their behaviour. Multicellular controllers envisage two cell populations, one made up of cells with embedded controllers (controller cells) and the other will be the controlled population (target cells). In addition, a rapid prototyping platform will enable to speed up the design-build-test cycles by means of optimal experimental design, microfluidics and cell-free systems. Proof-of-principles demonstrations in bacteria and yeast with relevance to biotechnology will be tackled to prove the usefulness of this revolutionary technology.

Keywords: control engineering,synthetic biology
Coastal ecosystem carbon balance in times of rapid glacier melt (CoastCarb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Argentina,Germany,Belgium,Poland,United States,Netherlands,Chile,Canada,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2025-07-31
Duration (months): 67.0
Total project cost (EUR): 1771000.0
EU funding (EUR): 1771000.0
Participants: 16
Project status: SIGNED

Climate change and intensifying human resource use are causing massive changes to Subantarctic coastal systems and carbon cycling. At the same time, these systems house benthic communities of highest biomass and biodiversity, which sustain important ecosystem services and require strategic observation and management plans. Although they are just beginning to be appreciated by scientists and public, natural (climate mitigation) and cultural ecosystem services (e.g. local fisheries, tourism, sustainable aquaculture) are already jeopardized by the massive scale and velocity of the regional change in Southern Patagonia (SP) and at the West Antarctic Peninsula (WAP). The multidisciplinary network CoastCarb joins experts in Subantarctic coastal system ecology and ecological modelling to create a knowledge information system with open access data portal and produce dynamic ecosystem models for fjordic and estuarine environments. Using data on carbon budgets and flow (including benthic and pelagic food webs, microbes to megafauna) from across the network, specialists will analyse the relationships between ecosystem services, local stakeholders and communities, to identify barriers and enablers of the sustainable use of marine resources. Study areas along the fragmented SP/WAP coastline are intensively investigated. Data sets from more than 10 recent interdisciplinary research projects of CoastCarb participants, and from the scientific core programmes at coastal stations (ARG-GER Carlini-Dallmann, US Palmer, UK Rothera, PL Arctowski) will be used for knowledge compilation. The established network is based on German, Belgian, Dutch, British, Argentine, Chilean and US participants with new Polish and Canadian partners included. CoastCarb secondments foster capacity building in research and observation for a better understanding of complex ecosystem processes and major hazard scenarios (e.g. harmful algal blooms), and in targeted science stakeholder interaction events.

Keywords: climate change,sub,antarctic coastal ecosystems,environmental knowledge system,ecological modelling,organismal adaptation,coastal carbon cycling,marine ecosystem services