Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering non-genetic determinants and targetability of cancer cell plasticity. (MaturingKidsCancer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Introduction Cancer cell plasticity, the ability of cancer cells to change their identity, enables tumors to adapt to hostile environments, aiding metastasis and resistance to treatments. Hence, plasticity is a major unsolved problem frustrating effective treatment. Unraveling the mechanisms underlying cancer cell plasticity is crucial to establish new avenues for cancer therapy. In contrast to adult cancers, many pediatric tumors are driven by a single genetic alteration that fuels their aggressive nature through remarkable plasticity. Despite their differences, pediatric cancers offer a unique platform to investigate cancer cell plasticity due to their genetically clear characteristics. I hypothesize that plasticity can be reversed to differentiate tumor cells and “mature cancer”. Goal Building upon previous ERC-StG funding, we have successfully utilized organoid technology, single-cell genomics, and lineage tracing approaches to uncover the origins of various pediatric cancers. Our findings revealed that these cancers exhibit robust yet pharmacologically reversible plasticity at the level of the epigenome. The goal of this proposal is to reverse cell state changes during tumorigenesis to “mature cancer”. Approach We will I) apply advanced (spatial) single-cell transcriptomics and epigenomics approaches to a unique cohort of pediatric tumors and metastases to map out cell state changes during disease progression, II) utilize our unique pediatric cancer organoids to interrogate and target hierarchical trajectories with the aim to mature cancer, and III) screen the enhancer-ome to identify non-genetic determinants of cancer cell plasticity. Innovation Integrating these cutting-edge technologies on patient-derived tissues and organoids will uncover fundamental principles governing cancer cell plasticity. The research will pioneer innovative methodologies and reveal strategies for identifying cancer maturation targets, advancing cancer therapy research

Keywords: cancer cell plasticity maturation therapy pediatric cancer tumor initiation and progression
Boosting sustainability of European aquaculture through Biofloc Technology (SwitchFloc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Portugal,Norway,Germany,Italy,France,Brazil
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-12-01
End date: 2029-11-30
Duration (months): 48.0
Total project cost (EUR): 3572142.17
EU funding (EUR): 3195594.0
Participants: 12
Project status: SIGNED

Aquaculture provides more than half of the world's seafood protein, but it faces challenges such as water demand and eutrophication, biosecurity or dependence on fishmeal/oil. Therefore, novel systems with low environmental impact are required to meet these challenges. Biofloc technology (BFT) is a novel aquaculture system that can recycle the C and N waste into valuable biomass suitable to be used on-site as a nourishing food source, reducing the need for aquafeeds and enhancing animal immune system. The N conversion into microbial fraction allows minimal water exchange, reducing water requirements. Moreover, BFT ensures biosecurity due to the absence of communication among tanks. However, BFT is still a relatively new technology, and needs to be better understood, mainly under intensive conditions. Besides, BFT is a complex multidisciplinary system, and the lack of qualified professionals is the main barrier to its implementation in Europe. SwitchFloc will face BFT challenges through an interdisciplinary and intersectoral research and training programme, including international secondments and a series of network-wide training events. SwitchFloc will focus both on species well adapted to BFT and species new to BFT and will improve aquafeed formulation and manufacturing, as well as animal health by promoting beneficial microorganisms into biofloc. Additionally, BFT sustainability and financial viability will be enhanced by the combination with IMTA and hydroponic systems (FlocPonics), analysis of carbon footprint, search of potential market opportunities and food quality assessments. SwitchFloc will train outstanding researchers in sustainable and intensive aquaculture production and will have deep technological impact in aquaculture by providing a new generation of BFT supporting technologies. In addition, SwitchFloc will impact economy and the environment by reducing artificial feed and water exchange, culminating in the production of fresh zero-km product.

Keywords: biofloc technology,penaeus vannamei,teleost
The sociocultural formation of prices in Mongolian medicinal plant supply chains (PLANTECON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Austria
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2025-03-31
Duration (months): 27.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 2
Project status: CLOSED

This action, PLANTECON, based at SINOFON, a research centre unit hosted by the Department of Asian Studies, Palacky University, aims to investigate the sociocultural formation of price along Mongolian medicinal plant (MP) supply chains. Within recent history, and intensively since the spread of Sars-Cov-2, MP supply chains--trade networks that move a product from its site of origin to a consumer market--have proliferated across Central Asia. In Mongolia, otherwise-unemployed poor rural populations gather wild-growing plants and sell them at negotiated prices--the agreed-upon economic value that solidifies the exchange of the plant from one actor to another--into trade networks that move the plant to consumers in urban Mongolia or China. The action has the following objectives: 1) identify the breadth and extent of the proliferating MP trade in two plants, Fang Feng and Liquorice Root, in Mongolia; 2) identify the diverse sociocultural factors that impact price negotiations in situ, following the process of price formation across a chain to identify how sociocultural considerations affect prices in the aggregate; and 3) establish the equitability potential of MP supply chains as rural development strategy. Academically, this action will advance economic anthropology on pricing; and environmental, medical anthropology on the globalised traditional medicinal plant trade with potential for future cross-geographic ERC or Twinning grant proposals. Economically and culturally, the action will draw attention to the booming, unregulated medicinal plant trade in Central Asia to increase cultural heritage and plant conservation action, but also inspire international funding bodies to either design value chain development projects that are equitable to rural populations or consider the implementation of plant benefit-sharing programmes.

Keywords: medicinal plant trade,traditional asian medicine,sociocultural price formation,supply chains
Imaging Ultrafast Single Particle Macromolecular Dynamics with X-ray Lasers (FemtoPix)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Conformational dynamics are crucial for the functioning of most macromolecules and a deeper understanding of these motions holds great promise for future discoveries in biology. But it is difficult to probe the structure of macromolecules away from their most stable conformations, and time-resolved studies remain limited by the available techniques. Today a new generation of XFELs is growing. The extremely short pulse duration, high pulse intensity and repetition rate of these lasers offer new research opportunities in physics, chemistry, and biology. Since the first XFELs were proposed, the idea of obtaining images of individual proteins frozen in time has fascinated and inspired many, and we have been at the forefront of this quest. The combination of advances in XFEL technology with ESI has brought the dream of imaging hydrated single proteins by X-ray diffraction within reach. Currently time-resolved studies in solution in the sub-ms range are done through solution X-ray scattering or spectroscopic methods, but they can only provide limited structural information. XFELs provide a way to dramatically improve our understanding of these time-scales. This proposal aims to develop the science and technology to make ultrafast single-protein imaging a reality, through a three-step approach: (I) develop diagnostics suitable for nanosized samples, (II) enable single protein X-ray diffraction imaging through new sample delivery instrumentation, (III) perform time-resolved single protein imaging experiments using the unexplored tender X-ray energy range. Ultrafast imaging of macromolecules will reveal new horizons. As a single-molecule method with high time-resolution, it enables imaging the structural changes associated with fundamental processes such as enzyme catalysis, allosteric signal transduction or even protein folding. It also opens a way to record molecular movies and mapping the conformational landscape of isolated macromolecules for the first time.

Keywords: x ray free electron lasers,x ray single particle imaging,diffraction before destruction,sample delivery,electrospray ionisation,ultrafast,structural dynamics,time resolved
Demonstrating energy intensive industry-integrated solutions to produce liquid renewable energy carriers from CAPTUred carbon emissionS (CAPTUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Norway,Italy,Germany,Greece,Belgium,Portugal,Netherlands
Call: Renewable energy carriers from variable renewable electricity surplus and carbon emissions from energy consuming sectors (HORIZON-CL5-2022-D3-02, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 11501125.0
EU funding (EUR): 9999706.39
Participants: 19
Project status: SIGNED

GHG emissions reduction policies to mitigate climate change heavily impact on energy intensive industries, leading to loss of employment and competitiveness. In addition, variable renewable generation faces high risks from electricity curtailment if renewable surplus is not used. Carbon capture and utilisation technologies that make use of industrial flue gas and renewable surplus will play a key role in the clean energy transition of industry. Various technologies exist but most are still quite demanding in terms of materials and energy, being costly and inefficient. CAPTUS key objective is to demonstrate sustainable, cost-effective and scalable pathways to produce high-added value energy carriers by valorising industrial carbon emissions and integrating renewable electricity surplus. To this end, 3 complete value chains will be demonstrated at 3 different demo-sites: (i) Bioprocess based on a two-stage fermentation to produce triglycerides in a steel plant, (ii) Lipids-rich microalgae cultivation followed by hydrothermal liquefaction to produce bio-oils in a chemical plant, and (iii) Electrochemical reduction of CO2 to produce formic acid in a cement plant. The proposed technologies will be tested at TRL7, and the obtained energy carriers will be validated by upgrading studies. CAPTUS will also validate solutions regarding economic, environmental, societal and geo-political criteria, contributing to the development of novel business models, guidelines and strategies. CAPTUS has been structured in 8 WP, combining R&D activities, project management and demonstration activities. CAPTUS addresses this complex challenge by gathering a competitive consortium of 18 partners from 8 EU countries. Overall, CAPTUS innovations at technical, economical, managerial and social level will enable the consolidation of CCU technologies within 3 EII key sectors and leverage their benefits by reducing carbon emissions, increasing renewables share and producing valuable energy carriers

Keywords: carbon capture and utilisation technologies,energy carrier,renewable energies,carbon emissions,co2 conversion processes,industry decarbonisation
Multidimensional Transition Pathway Analysis for Sustainable Futures: Exploring Alternative Paradigms and Broadening Policy Options through Innovative Scenario Development (MultiFutures)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Austria,Belgium,Poland,Greece,Türkiye,Portugal,Norway,Netherlands,Finland,United Kingdom
Call: Broadening the range of policy options in transition pathway analysis (HORIZON-CL5-2023-D1-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 4545590.0
EU funding (EUR): 4545590.0
Participants: 11
Project status: SIGNED

MultiFutures systematically broadens the scope for policy action towards sustainable societies by assessing and developing transition scenarios based on alternative economic paradigms. This involves extending established transition scenarios (e.g. the EC's 'Long term strategic vision' scenarios or the IEA’s net zero scenarios) to include alternative economic paradigms that are based on a wide spectrum of sound economic and social theories and have demonstrated potential to address global challenges. These paradigms introduce new policy options and instruments, which we aim to critically assess regarding their relevance, effectiveness, and potential trade-offs. The project will proceed through four main steps. First, we use state-of-the-art AI language tools and qualitative methods to map alternative paradigms and develop a paradigm taxonomy. Second, desired futures are extended into quantified transition scenarios using a set of 'beyond GDP' indicators to assess the potential for achieving a climate-neutral, just, and resilient society. Thirdly, stakeholder engagement through anticipatory systems mapping and social simulations will be used to co-create alternative futures and develop concrete policies that balance trade-offs, mitigate negative impacts, and enable dissemination and implementation. In addition, a large-scale survey of >18,000 citizens in Europe provides insights into public perception and acceptance of alternative paradigms and transition policies. Fourth, state-of-the-art modelling will be integrated to assess the economic, environmental, technological and social impacts of alternative paradigms and policies from a well-being perspective, including their environmental and social justice implications. Ultimately, MultiFutures provides policymakers with a comprehensive understanding of alternative paradigms and a broader range of policy options to accelerate progress towards a climate-neutral, just, and resilient society.

Keywords: transition scenario analyses,alternative economic paradigms,integrated modelling,stakeholder engagement
Safe Pathways to Protection for Displaced Populations in Canada and Europe (ESCAPES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-16
End date: 2029-01-15
Duration (months): 36.0
Total project cost (EUR): 306223.08
EU funding (EUR): 306223.08
Participants: 2
Project status: SIGNED

ESCAPES studies national and international responses to forced displacement from a comparative perspective. The project seeks to advance existing understandings of the policy, legal and institutional factors shaping states’ use (or non-use) of so-called ‘active refugee admission policies’ – resettlement and complementary pathways for admission of refugees to third countries – and to explore a set of normative issues raised by existing policies and practices. The project will achieve the above-mentioned aim through an interdisciplinary and multi-method examination of refugee admission policies adopted by Canada and a selected group of EU Member States (Germany, Italy and Sweden) in response to three large-scale displacement situations: the Syrian situation (2011 onwards), the Afghanistan situation (2021 onwards) and the Ukrainian situation (2022 onward). The project starts from the recognition that States’ responses to the above-mentioned situations have displayed significant differences in terms of numbers of people admitted, admission instruments and procedures, and the rights granted to beneficiaries upon arrival. Against this background, ESCAPES has the following main objectives: a) develop an innovative conceptual framework to shed light on the dynamics of national and international policy-making in the field of resettlement and complementary pathways, and explain variation in states’ responses to different refugee situations; b) contribute to the nascent literature on the role that refugee agency and autonomy (should) play in accessing and navigating refugee admission instruments; c) expand existing scholarship on a set of normative issues raised by resettlement and complementary pathways’ policies and practices, paying specific attention to aspects of equity and non-discrimination, procedural fairness, and access to rights.

Keywords: forced displacement,refugees,resettlement,human rights,non discrimination,european union,canada,institutionalism,policy framing
Rare earth and magnets hub for a resilient Europe (REMHub)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Finland,Italy,Spain,Ireland,Slovenia,Estonia
Call: Rare Earth and magnets innovation hubs (IA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 18117025.0
EU funding (EUR): 16000000.0
Participants: 24
Project status: SIGNED

REMHub project proposal will create a cutting-edge digital innovation hub propelling EU excellence for Rare Earth Elements (REEs ) and magnets. REMHub will develop test and pilot novel technologies for exploration and primary production of rare earths and recovering rare earths from side streams to enhance supply security of REEs in EU. In addition, Re-X (Recycle, Reuse, refurbishment and repurposing) technologies for rare earths and valuable metals from end-of-life products as well as electric machine design for easier permanent magnet recycling will be developed. The project will also identify and engage relevant stakeholders for developing REE value chain in EU. In addition, in the innovation hub will ensure that the novel technologies developed in the project will be commercialized and offered as services in a digital platform. The project will also have dynamic communication and dissemination with the aim to involve and engage the public to develop trust and awareness related to REEs as well as to build capacity in EU. The hub targets transformative material sourcing for REEs and REE magnets, including traceability, digital twinning, and digital passport. The project partners cover the entire REE value chain starting from mineral exploration, through mineral processing and refining to metal production and magnet making as well as recycling. The project incorporates safe and sustainable by design framework (SSbD) including design for Re-X (recycling, re-use, refurbishment, repurposing) approach integrating easy dismantling and circularity properties. REMHub will significantly improve the supply security of REEs in the EU and with the digital innovation hub considerably accelerate the development of technologies and services to faster and easier market entry.

Keywords: ree innovation hub,resilient ree value chain,supply security of rees and permanent magnets in eu,weee reycling,traceability,digital twins for re x,increased sustainability of rees