Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First Chemoselective Synthesis and Structural Studies of Lasso Peptides (FCSSSLP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-07-05
End date: 2019-07-04
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

The main objective of this project is to promote the use of peptides as potential therapeutic agents. We now know that ribosomal peptides, and specifically lasso peptides, which are biosynthesized by bacteria as agents of defense, show a compact and rigid structure, giving a high stability against physical, chemical and proteolytic degradation. The spectrum of biological activities of these peptides is very wide, acting as antibiotics and also as enzymatic inhibitors, such as the case of the HIV virus protease. Thus, they show a great potential as a therapeutic alternative to existing drugs. To achieve this goal, the project is divided into two distinct parts, to be performed in the two chosen sites, strategically combining the synthetic aspects (TSRI, San Diego) with the structural determination and their involvement in recognition molecular processes (CIB-CSIC, Madrid) . Firstly, synthetic efforts will be made to chemically synthesize the lasso microcin J25 (MccJ25). It will be an extraordinary example of how we, chemists, can use very complex chemoselective reactions, which are usually reserved for biosynthetic enzymes. During the second part of the project, the first structural studies of Lasso peptides-protein complexes will be accomplished using the synergy of combining NMR with computation methods. The selected research centers to achieve this project are: The Scripps Research Institute (TSRI), being the project supervisor Prof. Phil Baran and Centro de Investigaciones Biológicas (CIB-CSIC), with Prof. Jesús Jiménez-Barbero. Both research groups and centers have a well-gained international prestige.

Keywords: peptide,lasso peptide,microcin j25,rotaxanes,catenanes,protein chemistry,molecular recognition studies,structural determination,stabilities studies
Ultrafast Molecular Structural Dynamics (MolStrucDyn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Chemical reactions in solution are strongly influenced by femtosecond solvent-solute dynamics. Likewise, proteins provide specific environments to control the outcome of substrate reactions. The molecular understanding of these effect are currently poorly developed. I propose to fill this knowledge gap by ‘filming’ elementary chemical reactions in solution and in proteins. I will pioneer new time-resolved scattering and diffraction experiments using X-ray Free Electron Lasers (XFELs). Using femtosecond time-resolved X-ray scattering, I plan to decipher the structural dynamics of bond breaking and bond formation in iodine containing compounds in solution. I will pioneer time-resolved fluctuation correlation X-ray scattering to recover full electron density maps of the reaction trajectories at an atomic resolution. I will visualize the as yet unknown structures of reaction intermediates and the solvent response. Furthermore, I propose to investigate the molecular photoresponse of phytochrome photoconversion with femtosecond time-resolved serial microcrystallography. Phytochromes are ubiquitous photosensory proteins in plants and are essential to all vegetation on earth. I will resolve how the chromophore and the protein react collectively to photoexcitation and how this leads to conformational changes. Combined, this interdisciplinary project will yield microscopic understanding on how the surrounding of reactants guides the outcome of elementary (bio)chemical reactions. This program builds on my strengths in structural biology of phytochromes (Takala et al., Nature, 2014), time-resolved X-ray scattering (Westenhoff et al., Nature Methods 2010), and femtosecond spectroscopy (21 papers in PRL, JACS, Nature Methods 2006-2012 & 2016). The new XFEL-based methods will have wide-ranging applications in chemistry and biology. My work will open new horizons in physical chemistry and structural biology.
INitiative to bring the 2nd generation of ThermoElectric Generators into industrial ReALity (INTEGRAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Spain,Italy,Norway,Sweden,France,France,France,France,France,Netherlands,United Kingdom
Call: Pilot lines for manufacturing of materials with customized thermal/electrical conductivity properties (H2020-NMBP-PILOTS-2016, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 9384999.89
EU funding (EUR): 7000983.51
Participants: 16
Project status: CLOSED

Thermoelectric materials have been studied for several decades now. Improved TE materials are emerging with the so-called second-generation thermoelectric (GEN2 TE) materials: silicides and half-Heusler. These materials are low-cost, based on most earth-abundant elements and eco-friendly materials, and can impact positively European industry and society by converting wasted heat into electricity. As GEN2 TE materials are attracting a growing interest, pilot lines resulting from partnerships between public research institutes, industrial research teams and SME are emerging in Europe. The aim of the INTEGRAL project is to upscale the GEN2 TE material technology using existing pilot lines and growing SMEs, in order to address mass markets TE needs (automotive, heavy duty trucks, autonomous sensors and industry waste heat recovery). The INTEGRAL project is unique since it gathers in a complete value chain the major companies (including SMEs and startups) developing GEN2 TE advanced materials in Europe and cutting-edge research centers. INTEGRAL will allow the industry to step up towards advanced manufacturing and commercialization of systems integrating multifunctional TE materials (on a nano-based approach), through material customization, next techniques for characterization and process control and up-scaled pilot-line demonstrations of reliability, reproducibility and mastered material consumption. Furthermore, the large-scale processes which will be developed for producing nanostructured materials within the INTEGRAL project will explore a wider range of applications outside thermoelectrics, in particular where customization of electrical or thermal properties of sintered or casted materials are needed. Finally, a technology transfer will be performed from research activities to pilot-lines, towards the commercialization of the new generation of advanced materials with a circular economy vision.

Keywords: pilot line,nanostructured materials,sintering,casting,thermoelectrics,ribbon silicides,energy harvesters,bulk silicides,half heuslers,characterisation,in line control,automotive
A TRranslational approach to Identify Biomarkers for Asthma and Lung function impairment (TRIBAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2023-11-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Asthma is a chronic inflammatory disease of the airways that cause symptoms like wheezing and breathlessness. In children, asthma is the most common chronic disease and according to the WHO, more than 300 million people are affected globally. There is no curative treatment available. Persistence of childhood asthma into adult life is associated with lung function impairment and increased risk of chronic obstructive pulmonary disease, COPD. Evidence is now emerging that adult diseases, like COPD, may have their origin early in life. However, there are no established biomarkers that can accurately monitor asthma progression or predict development of COPD in adults. In this TRIBAL project, I will capitalize on rich longitudinal data and repeated bio-sampling from the Swedish BAMSE study, a world-leading population-based birth cohort of 4,089 participants with a new 24-year follow-up starting in 2017. A key aim with the new follow-up is to identify young adults in their 20s with persistent asthma and pre-stage COPD by advanced lung function assessment that includes bronchodilator and nitrogen washout tests. In TRIBAL, the unique setup is deep phenotyping of these patients describing different aspects of the respiratory system, as well as molecular characteristics of relevant bio-samples and cells. Disease-related biomarkers and involved mechanisms, from gene to protein, will be identified from early childhood to adulthood. Both the innate and the adapted immune system with detailed cell characterization will be explored in relation to exposure and disease development. Specifically, with this novel approach I will address the time point during childhood when disease processes related to persistent asthma and pre-stage COPD were initiated. The ultimate goal in TRIBAL is to provide new knowledge for targeted preventive efforts in children at risk of adult chronic lung disease, and to identify potential targets for new asthma and COPD drugs.

Keywords: asthma,biomarker,copd,prediction
Consumer driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain (PerformFISH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Spain,Italy,Italy,Italy,Spain,Spain,Spain,Spain,Italy,Ireland,Spain,Italy,Italy,Italy,Spain,Greece,Greece,Norway,Greece,Greece,Croatia,Norway,Croatia,Greece,France,France,France,France,France,Denmark,Portugal,United Kingdom
Call: Improving the technical performance of the Mediterranean aquaculture (H2020-SFS-2016-2, 2016)
Start date: 2017-05-01
End date: 2022-10-31
Duration (months): 66.0
Total project cost (EUR): 7045060.74
EU funding (EUR): 6997060.74
Participants: 41
Project status: CLOSED

Gilthead sea bream and European sea bass are by volume the third and fourth most farmed fish species in the EU, while their collective value surpasses that of salmon, trout or mussel. These two species are farmed and contribute significantly to wealth and job creation in rural and coastal areas in all EU Mediterranean countries. However, production of sea bream/bass in the EU has remained stagnant for the last decade and the industry faces significant sustainability challenges. The overarching objective of PerformFISH is to increase the competitiveness of Mediterranean aquaculture by overcoming biological, technical and operational issues with innovative, cost-effective, integrated solutions, while addressing social and environmental responsibility and contributing to “Blue Growth”. PerformFISH adopts a holistic approach constructed with active industry involvement to ensure that Mediterranean marine fish farming matures into a modern dynamic sector, highly appreciated by consumers and society for providing safe and healthy food with a low ecological footprint, and employment and trade in rural, peripheral regions. PerformFISH brings together a representative multi-stakeholder, multi-disciplinary consortium to generate, validate and apply new knowledge in real farming conditions to substantially improve the management and performance of the focal fish species, measured through Key Performance Indicators. At the core of PerformFISH design are, a) a link between consumer demand and product design, complemented with product certification and marketing strategies to drive consumer confidence, and b) the establishment and use of a numerical benchmarking system to cover all aspects of Mediterranean marine fish farming performance. Created knowledge and innovative solutions will underpin the developed code of conduct and good practices and will foster modernization through capacity building of the Mediterranean aquaculture workforce.

Keywords: gilthead sea bream,european sea bass,consolidation,industrial application,blue growth
IMA (Integrated Modular Avionics) for Small Air Transport (IMASAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Computing Node for Safety Critical Applications (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2022-06-30
Duration (months): 52.0
Total project cost (EUR): 1246716.25
EU funding (EUR): 869550.0
Participants: 3
Project status: CLOSED

IMASAT project focuses on the design, manufacturing and qualification of a new Computing Node suitable to be used as Flight Control Computer for Small Air Transport (SAT). The aim of the research is to define and implement IMA (Integrated Modular Avionics) concept for SAT, so that European industry players will be able to adopt fly-by-wire (FBW) systems to reduce the weight of avionics systems, reduce maintenance operations and enhance safety by improving the human-machine interface and automatically help stabilize the aircraft. The IMASAT project attends to Clean Sky aim to revitalize the European SAT industry by encouraging the insertion of a range of new and cost effective technologies in the area of systems for a future new generation small transport aircraft (Airframe ITD WP B3.5 and Systems ITD – WP S.3). IMASAT’s answer to this challenge has been to rethink avionic computers at all levels: system, architecture, design, software, production and certification. IMASAT system innovations characteristics is based on the concept of a Modular Architecture with pre-certified Aerospace safety-standards, capable to support ARINC-653 compliant RTOS. IMASAT allows a flexible configuration that is tailor-made for users’ operative needs. IMASAT will be a ready-to-use, changeableness, and non-wiring system to allow users to implement expansions from the basic package, with a reduced weight and volume, and compliant with ETSO-2C153 at DAL A. IMASAT will use a main network high-speed AFDX safety Ethernet-based fulfilling ARINC 664 requirements in FCS. The final goal is Small Air Transport to be benefit by IMA second generation for more safety and efficient operations and Higher performances, versatility and robustness in avionics. With this aim, the best consortium has been built for IMASAT, is led by AERTEC, a LE with 20 years of experience on the sector, who has the privilege of working with CLUE, an SME well-known for its innovative electronic systems for aerospace.

Keywords: dme architecture,scalability,swap c
European Brain Research Area (EBRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Germany,Switzerland,Belgium,France
Call: Coordinating European brain research and developing global initiatives (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 1997648.0
EU funding (EUR): 1997648.0
Participants: 6
Project status: CLOSED

Brain research in Europe is a rapidly evolving field, and increasingly at the forefront of science. The complexity of understanding physiological brain functions and brain diseases brings responsibilities to develop novel tools and approaches to advance our understanding of unknown basic brain functions, as well as opportunitiesto generate novel therapeutic approaches, thus confronting with a major societal challenge in Europe and worldwide. Considering the costs of brain diseases for the European society, and that these costs will increase considerably in the coming years due to the ageing of the European population, the EU and its Member States have made considerable investments in brain research leading to a significant increase of initiatives in this area. Although these initiatives have generated considerable amounts of knowledge and innovative approaches, the translation into new health interventions is hindered by the complexity of the challenge and by excessive fragmentation of the efforts. Effective and efficient collaboration and cooperation among the various initiatives are often identified as a key success factor to achieve brain research full impact. In particular, there is a constant need for strengthening the information flow and accelerating the exchange of experience on the on-going and future projects as well as maintaining continuous dialogue between all the stakeholder groups and initiatives to allow that objectives are aligned and needs are met. EBRA will fully respond to these needs by bringing together the various stakeholders and major brain research initiatives, at European level and beyond, and creating the conditions for real and effective cross fertilisation, dialogue, building consensus and exploiting research potential to deliver new health interventions in brain disorders.

Keywords: research coordination,research strategic agendas
Mechanisms of chromatin organization and reprogramming in totipotent mammalian zygotes (TotipotentZygotChrom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria,Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1555255.0
Participants: 2
Project status: SIGNED

Totipotency, the developmental potential of a cell to give rise to all cell types, is naturally achieved when differentiated egg and sperm fuse to form the one-cell zygote. How chromatin is epigenetically reprogrammed to totipotency within hours after fertilisation remains a central question in biology. We aim to address this by investigating the mechanisms of reprogramming and the spatial reorganisation of chromatin in mammalian zygotes. Our interdisciplinary approach combines mechanistic cell biology with genetics and genomics to understand how chromatin reorganisation promotes totipotency and to identify key regulators of this process in zygotes. Molecular insights into reprogramming to totipotency are crucial to understand the essential zygotic stage of sexually reproducing species. A better understanding of how cells naturally reprogram chromatin to totipotency, a state upstream of pluripotency, has the potential to improve induced reprogramming technology and revolutionize regenerative medicine. Our aim is to understand how chromatin is reprogrammed to totipotency. To reach this ambitious goal: 1) We will discover new general concepts of genome organization, as well as reprogramming-specific aspects, by capitalising on our recently developed single-nucleus Hi-C method to dissect spatial reorganisation of chromatin in zygotes. We will investigate the relationship between chromatin reorganisation and transcription. 2) We will uncover mechanisms of zygotic reprogramming by elucidating the loci and factors that support active DNA demethylation during reprogramming of the paternal genome. 3) We will illuminate the origins and contributions of the oocyte since the factors responsible for reprogramming likely reside as proteins or RNA in the unfertilized egg. Overall, these studies will provide novel insights into how chromatin is reprogrammed and spatially reorganised towards a totipotent state that facilitates zygotic genome activation.

Keywords: chromatin organization,totipotency,epigenetic reprogramming
Experimental Epidemiology in Ant Societies (EPIDEMIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany,Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-08-01
End date: 2026-01-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1348298.91
Participants: 3
Project status: SIGNED

The risks and impact of disease are exacerbated in social organisms, which live in dense groups wherein pathogens can rapidly propagate. Theoretical epidemiology predicts that disease dynamics will depend in large part on a group's social interaction network, but empirical data are scarce. Experimental epidemiology is currently hampered by a lack of study systems that would enable a rigorous investigation of the causal link between network structure and disease transmission. I will tackle this question using a novel system, the clonal raider ant, a social insect whose unique biology affords unparalleled control over the main aspects of colony composition that are thought to modulate social network structure, and therefore, disease transmission. My approach will combine cutting-edge automated techniques for behavioral tracking with molecular tools, and develop new methods to monitor transmission in real time. In a first step, I will create empirical networks that are theoretically predicted to vary in transmission risk and map individual immune function onto these networks, to measure the prophylactic network properties that might reduce disease transmission. Second, I will test if experimental increases in immune activity induce changes in behavior that are relevant for disease transmission, to measure inducible network properties. Finally, I will inoculate colonies with nematodes and quantify infection propagation in real time. This will allow me to compare various types of social networks (healthy, immune-activated, infected), to probe the link between behavior and immunity, and to experimentally test predictions from theoretical epidemiology. This project takes an integrative approach—from individual immunity to collective behavior—to uncover the properties of social groups that protect them against disease. By linking theoretical epidemiology to real-world disease dynamics, it will push the limits of our ability to predict disease dynamics in social groups.