Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building Green and Climate Neutral City-Hubs (CLIMABOROUGH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Italy,Germany,France,Slovenia,Bulgaria,Greece,Portugal,Luxembourg,Croatia,Poland,Czechia,Bosnia and Herzegovina,Montenegro,Norway,Denmark
Call: Urban planning and design for just, sustainable, resilient and climate-neutral cities by 2030 (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 11408458.75
EU funding (EUR): 11037882.75
Participants: 29
Project status: SIGNED

CLIMABOROUGH is an Innovation project designed to field test the ClimHub, Climate Sandbox and Climate Service concepts within 12 European Cities engaged in their ecological and digital transition. The project aims to enhance traditional urban and spatial planning approaches through data and knowledge based decision making (including a possible new role for GIS - Geographic Information Systems), including climate services co-production for transitions, cross-city and cross-country pilot co-creation as well as the tactical use of public procurement of innovative solutions. The goal is not just to enhance an open set of tools leveraging climate transition in cities, but also to boost the exchange of experimental good practices, experiences and lessons learnt in this field, to help cities meet climate neutrality by 2050. This will be achieved by the following expected results: (A) building ClimHubs of Cities and solution providers to work on experimentations in real conditions, (B) harnessing the collective intelligence of local stakeholders for collaborative solution development, (C) defining Climate Services as a model strategy to use data and visualisation tools for climate transition, (D) field testing the Climate Sandbox concept as a way to prioritise and facilitate transformation of successfully deployed prototypes into established solutions for climate adaptation and mitigation in cities, and (E) monitoring and assessing the progress in achieving those goals and in implementing a climate neutrality planning scheme. Based on the lessons learnt and successful concept of the H2020 Designscapes CSA, CLIMABOROUGH has the ambition to bridge the gap between design and implementation of urban innovations, particularly in the domain of climate change adaptation and mitigation.

Keywords: climhubs,climate sandbox,climate services,innovative public procurement
GUIding multi-moDal thErapies against MRD by liquid biopsies - GUIDE.MRD (GUIDE.MRD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Germany,Denmark,Netherlands,France,Spain,Sweden,United Kingdom,United States,Belgium,Switzerland,Italy,Austria,Romania
Call: Personalised oncology: innovative people centred, multi-modal therapies against cancer (HORIZON-JU-IHI-2022-01-single-stage, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 34392421.41
EU funding (EUR): 17660955.0
Participants: 35
Project status: SIGNED

Advancing personalized approaches in cancer therapy, aiding identification and adaptation of multi-modal treatment strategies for improved outcomes depends on clinical implementation of novel diagnostic technologies. For most cancer types the risk-features used to select individuals for post-operative adjuvant multimodal therapy are suboptimal, where many patients are overtreated and others undertreated. Liquid biopsy has opened a new diagnostic avenue to detect and monitor minimal residual disease (MRD) in individual cancer patients, especially for selecting patients for multi-modal therapies post-operatively. However, despite many circulating tumor DNA (ctDNA) diagnostics being developed there is a lack of standardization, harmonization, and robust data to demonstrate clinical validity. GUIDE.MRD is a consortium of leading academics, technology companies, pharmaceutical companies, and experts in multi-stakeholder engagements. Together, we will tackle the critical questions by developing reference standards for ctDNA diagnostics, clinically validate promising ctDNA diagnostics and develop data to guide the use of multi-modal therapies with a non-invasive diagnostic test. With robust engagement with regulatory authorities, payers and importantly patients themselves, we will develop recommendations and guidelines based on objective data to use ctDNA diagnostics to guide multi-modal therapy selection to improve patient outcomes.

Keywords: circulating tumor dna ctdna,minimal residual disease mrd,standardization,precision medicine
Highly-Efficient Seeded Frequency Comb Generation on a Chip (COMBCHIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Generating new colors (frequency components) of light through nonlinear optical phenomena is one of the key drivers of modern optical technology. The spectrally diverse coherent light, widely known as an optical frequency comb, can be produced through a nonlinear process. The optical frequency comb enables energy-efficient optical communication, precision spectroscopy, and optical atomic clock. However, the frequency comb sources currently rely on bulky and power-hungry laser systems hampering their deployment outside the laboratory environment. There are great demands in lowering the size, weight, and power (SWaP) of such broadband light sources. Despite the significant progress in the miniaturization of comb systems and microcomb technologies. it is still a huge challenge to drive a broadband (larger than an octave) comb with microwave repetition rate using on-chip pump sources due to the limited performance of on-chip lasers. The COMBCHIP project aims to develop an ultra-efficient comb generator by combining the highly nonlinear AlGaAs waveguide and a newly developed seeded pumping scheme. The developed comb sources feature an octave-spanning bandwidth, microwave repetition rate, and ultra-low operation power, enabling chip-scale comb systems in emerging applications such as atomic optical clocks in satellites and mid-infrared spectroscopy.
Mitochondrial Fission 1 protein Interactions: from discovery to Acute myeloid leukemia pathophysiology and Therapy (FIAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Mitochondrial morphology is controlled by a set of “mitochondria-shaping” proteins that govern fusion and fission of the organelle. Fission is executed by dynamin-related protein 1 (DRP1) that binds to adaptors on the outer mitochondrial membrane to oligomerize and sever mitochondria. Fission 1 (FIS1) is among the putative mammalian DRP1 adaptors, but it appears dispensable for mitochondrial fission. Conversely, FIS1 seems to participate in the regulation of mitochondrial autophagy (mitophagy), interaction between mitochondria and lysosomes, and apoptosis. Because of these multifunctional roles, FIS1 emerged as an appealing pharmacological target and peptides inhibiting its interaction with DRP1 have been advanced in the experimental treatment of ischemia-reperfusion and of genetic conditions such as Huntington’s disease. More recently, FIS1 was identified as a crucial factor to sustain Leukemia Stem Cells (LSCs) in Acute myeloid leukemia (AML), the second most prevalent and the most fatal leukemia in adult patients. However, our scarce knowledge of the biology of Fis1 is mirrored by the uncertainties on how FIS1 regulates AML LSCs. To close this gap in knowledge, I will take a chemical biology approach and design innovative genetically encoded sensors for FIS1 functions that I will use to identify potential FIS1 small molecules inhibitors. I will then use these chemical probes to evaluate which cellular function of FIS1 is essential for maintenance of AML LSCs. Overall, this project will unveil how a multipronged mitochondrial protein regulates cell pathophysiology and will deliver novel chemical tools to investigate FIS1 function in the context of AML and potentially to evolve into therapies for this hitherto poorly treatable cancer.

Keywords: mitochondria,dynamics,fission,acute myeloid leukemia,in silico drug screening
Multi-Omics-based BIomarker Signatures of dietary Carbohydrates qUalITy and risk of chronic diseaseS. (BISCUITS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 2
Project status: SIGNED

The prevalence of type 2 diabetes mellitus (T2D), cardiovascular disease (CVD), and dementia is rapidly increasing worldwide and is therefore a major public health concern. Carbohydrate intake (40-80%) represents the main source of energy in most populations and the quality more than the quantity has a large effect on health. Recently, a “carbohydrate quality index” (CQI) emerged as a exposure that captures the combined and potentially synergistic effects of dietary glycemic index and intakes of total fiber, whole grains, and liquid or solid carbohydrates in a comprehensive manner. A high dietary carbohydrate quality assessed by the CQI has been associated with lower risk of T2D, CVD, and intermediate risk factors. However, the precise mechanisms of the associated beneficial effects offered by high CQI scores remain unresolved partially due to the lack of accurate biomarkers reflecting their exposure and the minimal information available on how CQI impacts the gut microbiota. The main objective of BISCUITS is to identify multi-omics signatures of dietary carbohydrate quality assessed by the CQI and evaluate their associations with the risk of chronic diseases in adult populations. We will integrate metabolomics and microbiota datasets using novel machine learning algorithms to identify combined panels of metabolites and microbial species reflecting the exposure to high CQI scores. We will also investigate the potential associations of these signatures with the risk of T2D, CVD, and dementia in two populations. Similar studies to this are not available in the literature and have the potential to discover novel biomarkers of CQI exposure and map biochemical mechanisms explaining the complex relationship between CQI and these diseases. This could open new avenues for the prevention and management of cardiometabolic and neurodegenerative diseases, resulting in easy-to-follow lifestyle recommendations and strategies that general population and patients can easily adopt.

Keywords: metabolomics microbiota diet carbohydrates quality biomakers chronic diseases
THERMODYNAMICS-DRIVEN CONTROL MANAGEMENT OF HYDROGEN POWERED AND ELECTRIFIED PROPULSION FOR AVIATION (TRIATHLON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Italy,Türkiye,Austria,Czechia
Call: Accelerating climate-neutral hydrogen-powered/electrified aviation (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3998865.0
EU funding (EUR): 3998865.0
Participants: 8
Project status: SIGNED

In order to mitigate the negative impact of human activity on the environment, significant efforts to lower carbon emissions are being pursued at both the global and European levels. Globally, the aviation industry aims for a 50% reduction of its carbon emissions by 2050, relative to 2005. In this transition towards net zero carbon emissions, novel powertrain technologies exploiting fuel cells and/or combustion systems that rely on hydrogen will play a significant role. TRIATHLON will use the synergy between powertrain components to overcome the challenges associated with scaling up hydrogen powertrain technology to MW class. The ambition of TRIATHLON is the development of disruptive approaches to design more robust, low-maintenance, low-emmision, highly responsive hydrogen-electric powertrains for megawatt class aircraft. When the distruptive technologies developed by TRIATHLON are adopted by the industry beyond TRIATHLON, it will lead to: 1) Reduction of emissions by implementation of NOx reduction strategies like injection of exhaust water of the FC into the CC and by capturing vented and permeated hydrogen and recompressing it; 2) Elimination of the need for a cryogenic pump by using a high-pressure storage buffer for pressurisation of the fuel distribution system (making the fuel distribution more robust for turbulence as well); 3) Reduction of the power required for hydrogen conditioning using excess heat from FC and CC by means of 3D printed heat exchangers using innovative materials like ceramics, and smart thermal management; 4) Improvement of the gravimetric index of the entire powertrain by providing an effective heatsink to powertrain components, reducing the need for coolant, allowing design of a more compact and lightweight CC, as well as the need for insulation of the hydrogen storage whilst enabling a longer dormancy time.

Keywords: hydrogen,thermodynamics,multidisciplinary research
SustainabLe sUCcinic acid production using an integRAted electrochemical bioreactor and renewable feedstock (LUCRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Belgium,Germany,Greece,Italy,Spain,United Kingdom,Finland,Netherlands
Call: Cost-effective production routes towards bio-based alternatives to fossil-based chemical building blocks (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 5709511.25
EU funding (EUR): 4682743.25
Participants: 11
Project status: SIGNED

LUCRA will exploit the EU’s underutilized and abundant, Municipal Solid Waste and Wood waste as feedstocks for the large scale production of platform building block biobased chemicals at high yield with significant industrial end-user interest using a circular bioeconomy biorefinery approach. It will provide optimized and scaleable ‘breakthrough first of a kind’ innovative technology to create a step change from pilot to large scale integrated fermentation with novel electrochemical extraction of succinic acid (SA) at TRL7 that will facilitate its industrial implementation, business models and market feasibility. This will be achieved by the circular utilization of the mentioned renewable resources as feedstocks which will reduce to a large extent the dependence on fossil resources and achieves at the same time a sustainable SA production route. To fit the needs of the industrial level, LUCRA will optimize the hydrolysis process of the different feedstocks to obtain efficient cellulose and hemicellulose conversion. Enzymatic cocktails will be demonstrated aiming to maximize hydrolysis of fermentable carbohydrate content with low inhibitors production. The crude sugar-rich hydrolysates will be used as fermentation feedstock in an electrochemical membrane bioreactor for efficient extraction and production of SA. In situ extraction of SA will be achieved through an anion exchange membrane resulting in simultaneous acidification, concentration, lower NaOH consumption for pH regulation and less unit operations for SA purification. To demonstrated the produced SA that will be able to compete directly their fossil-based counterparts from petrochemical processes, different polyurethane dispersions and resins will be produced at semi-industrial scale. The process implemented in LUCRA targeting to reduce the cost of bio-SA and will demonstrate an 50% GHG reduction against conventional SA.

Keywords: fermentation,in situ product recovery,ofmsw,forestry waste,building blocks,organic acids,succinic acid,polyester polyol,demonstration
Traits and Games: How Personal Cognitive and Psychological Features Affect Strategic Behavior (TRAITS-GAMES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1874575.0
EU funding (EUR): 1874575.0
Participants: 1
Project status: SIGNED

I will analyse how agents’ traits affect behaviour and strategic reasoning in decision problems and games. Traits encompass stable cognitive and psychological features of agents, such as tastes, skills, cognitive abilities, attitudes toward uncertainty and misspecification, concerns for others, and propensities to be affected by emotions. To build an adequate formal framework, I will try to comply with a separation principle: the description of the rules of interaction should be separate and independent from the description of players’ traits. This will enable a fruitful and conceptually rigorous analysis of personal traits in games, including players’ abilities and cognition, analogous to what has already been done—for example— concerning attitudes toward risk. Also, to model interactive strategic thinking (a.k.a. epistemic game theory), I will use a flexible approach that, unlike the standard one, does not assume common knowledge of cognitive rationality (e.g., of coherence). I will start with individual decision making and planning and then embed the analysis in interactive situations, with a special attention to sequential decision making and the role of time. Building on and improving upon my previous work on the foundations of game theory and psychological games, most of the analysis of the impact of traits on behaviour will be either focused on steady-state long run outcomes, using variations of the self-confirming concept, or outcomes consistent with subjective rationality and strategic reasoning, characterized by variations of rationalizability. Examples of the research questions to be addressed are the following: (1) How do cognitive feature affect strategic interaction? (2) Can institutions and agreements be robust to assumptions about interactive knowledge and beliefs about traits when players reason by forward induction? (3) How can we model context-dependent motivations? (4) What is the impact on long-run of concerns for misspecification?

Keywords: extensive game form,information flows,cognitive features,psychological motivations,subjective rationality,beliefs,strategic reasoning,steady states
Membrane Interaction Modulates RNA Secondary Structures and Phase Separation (MIMoSeS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

To maintain homeostasis, cells utilize compartmentalization, traditionally achieved through membrane-bound organelles. However, recent discoveries have highlighted the importance of membrane-less compartments, known as biomolecular condensates (BCs), which form via liquid-liquid phase separation (LLPS). BCs, rich in nucleic acids and proteins, create distinct chemical environments that regulate key metabolic processes and can be temporally controlled. Dysregulation of BCs is linked to diseases such as cancer and neurodegeneration. Whilst the role of proteins in LLPS has been extensively studied, nucleic acids' contribution has been underexplored and attributed solely to electrostatic effects. More recently, it has been demonstrated that nucleic acid alone can drive phase separation, and G-quadruplex (G4), a non-canonical secondary structure, has been identified as a key element. G4s are formed in guanine-rich sequences and can act as crosslinking elements, promoting multivalent interactions required for LLPS. However, understanding the molecular mechanisms of RNA-driven phase separation remains incomplete. A key challenge is identifying mechanisms that reduce the critical concentration required for RNA-based phase separation, making models more biologically relevant. In MIMoSeS, I investigate the role of phospholipid membranes in promoting RNA condensation by selectively recruiting specific RNA secondary structures to their surface, thereby lowering the concentration needed for phase separation. While this mechanism is known for protein-based BCs, it is still underexplored for RNA. MIMoSeS will identify and describe the interplay of lipid membranes and RNA G-quadruplex structures as a putative mechanism for Liquid-Liquid Phase Separation and will provide new insights to study RNA biology from a fresh perspective.

Keywords: liquid liquid phase separation,nucleic acids,phospholipid membrane