Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CRItical raw maTERIAl treatment and recovery from mining tailings and waste dumps (CRITERIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Portugal,Sweden,Spain
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 3481917.94
EU funding (EUR): 3370730.4
Participants: 9
Project status: SIGNED

The characterization and cultivation of tailing dams and waste dumps for the treatment and subsequent recovery of critical raw materials is an actual priority concerning Eu member States. This activity is both linked to the purpose of the remediation of old mining sites for a new employment of the area and the soil reuse and to actually developing mining activities. In this perspective the geophysical charaterization of tailing dams in order to organize the subsequent excavation and treatment activities is fundamental together with the social acceptance and the environmental impact evaluation of all the process. According to the different kind of excavated materials and the related content of critical raw materials physical and chemical treatments may be proposed such as: sieving, magnetic and electric separation, fluid media separation, chemical and/or biological leaching, crystallization and precipitation, solvent extraction, membrane-based processes or the integration of those. All the performed operations must be evaluated according to environmental and economic aspects.

Keywords: mining tailing recovery,waste dumps minimization and recovery,circular economy,innovative treatment technologies,environmental sustainability
The role of SYNGAP1 isoforms in brain development (SYNGAP-IsoDev)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 430343.4
EU funding (EUR): 430343.4
Participants: 2
Project status: SIGNED

Synaptic Ras GTPase activating protein (SynGAP) is crucial for neuronal communication and is highly concentrated in excitatory synapses. Mutations in the SYNGAP1 gene cause SYNGAP1-related intellectual disability (SRID), a neurodevelopmental disorder characterized by epilepsy, developmental delay, and autism. As there is no cure for SRID, this proposal will elucidate SYNGAP1 expression and function during development. In the adult brain, SynGAP regulates synaptic plasticity by interacting with other proteins to modulate synaptic strength. Recent studies suggest non-synaptic functions for SynGAP during neurodevelopment, regulating cell type specification in early cortical formation. This study will pioneer the investigation of SYNGAP1 isoform function and regulation across brain development. SYNGAP1 encodes for multiple N- and C-terminal isoforms with unique roles in synaptic function. Mouse models revealed that SynGAP-α1 affects synaptic plasticity, while SynGAP-β influences dendritic growth. Despite this, the regulation of the gene and its mRNA and isoform expression, especially during neurodevelopment, remains poorly understood. Preliminary analysis shows differential SYNGAP1 N-terminal isoform expression prenatally compared to adult brain. We hypothesize that (i) SYNGAP1 isoform expression is transcriptionally regulated in neurodevelopment with differential isoform usage between pre- and postnatal stages, and (ii) these isoforms have unique functions. We find that CRISPR activation (CRISPRa) upregulates Syngap1 in adult mouse hippocampus, offering a promising approach for modulating isoform expression. To test these hypotheses, we aim to employ cutting-edge techniques in mouse and human SRID models. Approaches include targeted long-read sequencing, intrahippocampal CRISPRa, behavioral phenotyping, and human cortical organoids. The goal is to uncover mechanisms of isoform-specific functions and their impact on SRID, potentially informing new therapies.

Keywords: syngap1,isoforms,post transcriptional regulation,mouse models of neurodevelopmental disorders,hipsc derived organoids,crispra,targeted long read sequencing,mouse stereotaxic surgery
Geoarchaeological Relations between Architectural Space and Social Practices (GRASSP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

The understanding of architectural space is of fundamental importance in archaeology. However, to fully comprehend architectural space, both social practices and activities (as well as their temporality) should be taken into consideration as cultural groups not only create space but also define themselves through the activities that they perform within and around it. This reflexive relationship between space and society is challenging to study, especially in Mediterranean prehistory. While part of the problem lies with the way social theory is applied to archaeology and the understanding of space, the biggest challenge consist in the poorly preserved record regarding architecture and activities, and in the lack of methodology to implement the data resolution of archaeological deposits. The proposed project, “Geoarchaeological Relations between Architectural Space and Social Practices” (GRASSP) seeks to propose a new theoretical and methodological approach to the study of space in archaeology. GRASSP propose to study the relationship between architectural space and social practices at the Mycenaean site of Pylos (Greece) by using cultural sediments as primary dataset. GRASSP has access to a unique dataset of samples and it uses an interdisciplinary methodological and theoretical toolkit consisting of archaeological and social theory, and diverse geoarchaeological techniques in order to reveal the architectural characteristics of the buildings, identify the type of activities performed in these structures, their temporality (transformation/abandonment), and their associated knowhow. GRASSP will bring attention on aspects of material culture that are other than material while rediscussing the role played by cultural sediments in the understanding of space and practices. It will also advance the archaeological discipline by filling deficiencies in methodology and theory applied to the study of the active mutual relationship existing between space and social practice.

Keywords: anthropogenic sediment,built environment,geoarchaeology,architectural space,social practices
Rewire the lymph node niche to instruct T cell immunity (REWIRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499730.0
EU funding (EUR): 1499730.0
Participants: 1
Project status: SIGNED

Lymph nodes (LN) are communication centers within the lymphatic network that instruct T cell priming and differentiation in homeostasis and disease. Multiple layers of control are achieved by a complex network of signals from stromal and immune cell compartments. As a result, spatially segregated LN niches coexist that foster diverse T cell lineages. In the context of cancer, T cell differentiation is pushed towards the lineage of exhaustion, with a progenitor exhausted T cell population arising in the LN. Hence, LN are central anatomic sites where T cell exhaustion can be controlled and reversed to eliminate cancer. The key question of REWIRE is: What microenvironmental factors determine the differentiation and maintenance of progenitor exhausted T cells in the LN? Tumor-derived signals reprogram stromal and immune cells within tumor-draining LN. Thus, a premetastatic niche is formed that supports future metastatic seeding while establishing an immunosuppressive microenvironment. I hypothesize that signals guiding T cell differentiation are altered by premetastatic remodeling of the LN niche, resulting in the generation of exhausted T cells. In this project, I aim to (1) decode spatial determinants of the progenitor exhausted T cell niche; and to (2) manipulate the tumor-draining LN ecosystem to control T cell immunity. The overarching goal is to dissect how tissue architecture directs molecular responses within the LN niche to regulate T cell exhaustion. We will use high-dimensional imaging technologies to chart the spatial context of progenitor exhausted T cells following tumor progression; as well as a novel myeloid cell-based in vivo delivery platform to specifically target tumor-draining LN. REWIRE will uncover basic mechanisms of communication between the LN microenvironment and differentiating T cells in the LN; as well as explore the novel concept of controlling T cell responses via manipulating key-features of the LN niche.

Keywords: tumor draining lymph nodes premetastatic niche tumor microenvironment
Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems (UNRAVEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The growing number of classes of RNA therapeutics, including siRNA, mRNA and RNA components of the CRISPR/Cas9 machinery, hold the promise of providing new treatment possibilities for almost any disease. However, these interventions require delivery of therapeutic RNA to their final intracellular targets in diseased cells, and delivery efficiency by current RNA nanocarriers is unsatisfactory. Endogenous nanoparticles called extracellular vesicles (EVs) have emerged as promising novel RNA delivery systems, due to their intrinsic ability to transfer biological cargo between cells in a selective manner. In fact, with my ERC StG, I have shown that EVs outperform synthetic carriers in terms of RNA delivery efficiency. However, EVs are a heterogeneous population of vesicles that differ in their targeting and cargo delivery properties, which forms a hurdle for the design of EV-based delivery systems. As methods to separate EV subpopulations and study their characteristics individually are lacking, a fundamentally different approach to address this hurdle is necessary. The aim of UNRAVEL is to reveal how variations in EV composition lead to specialized subpopulations with unique delivery features. Using this knowledge, I will develop the first biomimetic class of EV-inspired synthetic RNA delivery systems. I will pursue three objectives: 1) Identify EV subpopulations with unique targeting and RNA delivery properties using a novel EV barcoding strategy 2) Define these EV subpopulations in terms of unique surface properties, intracellular trafficking and cargo release 3) Apply this knowledge to improve synthetic RNA delivery systems by incorporating molecular features from EV subpopulations This work will significantly advance our understanding of the natural targeting and RNA delivery mechanisms of EV subpopulations and may result in a new generation RNA delivery system based on EV mimetics. In turn, this will allow more widespread application of RNA therapeutics.

Keywords: exosomes,extracellular vesicles,rna therapeutics,drug delivery
The basic principles of polyploidy in plants and animals (HOW2DOUBLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany,Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1495898.0
EU funding (EUR): 1495898.0
Participants: 2
Project status: SIGNED

Many eukaryotes have more than two sets of chromosomes due to whole-genome duplication (WGD) and are called polyploids. WGDs explain many cases of speciation bursts and evolutionary inventions. Some evidence suggests an adaptive advantage of polyploids: the origins of many ancient WGDs correspond to the times of extreme climate change, and contemporary polyploids often occupy harsher environments compared to their ancestors. However, most new polyploids are not as lucky and rarely survive. To explain the cause, predict and manipulate this process, we need to understand the basic principles of polyploidy: (1) how it is triggered, (2) what enables the initial survival of newly formed polyploids, and (3) how they stabilize a population and become successful. My program will comprehensively cover all these aspects, from the functional and genetic levels to the evolutionary forces driving the entire process. I propose a cross-disciplinary approach to identify common polyploidy principles in plant and animal diploid-tetraploid species complexes: Arabidopsis lyrata, widespread plant in Northern Hemisphere, and Neobatrachus, burrowing frogs living in the Australian desert. The approach combines classic genetics with the latest genomics technologies and population genetics analysis of natural herbarium and museum collections across broad geographies. I will (1) expose genetic and environmental predispositions to polyploidy formation by mapping natural variation of the unreduced gametes rates; (2) reveal mechanics and genetics stabilizing meiosis in polyploids, comparing recombination and selection across ploidies; (3) uncover polyploid populations recovery processes after bottlenecks accompanying their origin by reconstructing introgression patterns. Deciphering the mechanisms leading to successful polyploidization across the plant and animal kingdoms will deliver groundbreaking advances relevant across biology, agriculture, and medicine.

Keywords: polyploidy,meiosis,adaptation,introgression,population genetics,cytology
Towards a New Theory of Optimal Dynamic Graph Algorithms (DynOpt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1400000.0
EU funding (EUR): 1400000.0
Participants: 1
Project status: SIGNED

Dynamic graph algorithms are of increasing critical importance. They are crucial for coping with dynamic networks, which model the ever-changing physical world, and have been instrumental in achieving numerous major breakthroughs in static graph algorithms. The holy grail in the field of dynamic graph algorithms has been to design algorithms with poly-logarithmic (in the input size) update time. However, recent exciting developments, in which the PI has played a central role, aim to push the update time toward an absolute constant independent of the input size – which is qualitatively very different than a poly-log bound. This goal is of fundamental importance not just from a theoretical perspective, but also from a practical viewpoint, due to the rapidly growing size of modern networks. An algorithm is intrinsically optimal if its update time matches the ratio of the problem’s static time complexity to the input size. The main question underlying this research is: Which graph problems admit intrinsically optimal update time? Only few intrinsically optimal graph algorithms are known. The unique goal of this project is to establish a systematic study of intrinsically optimal algorithms. We will also study provably optimal algorithms, aiming to advance our understanding of the thin line that separates these two distinct optimality notions. To achieve this goal, we must go far beyond the current state-of-the-art, and in particular, confront some of the most central problems in the field. Meeting the project’s main goal, even partially, will be groundbreaking. Results of this project will facilitate the use of dynamic algorithms in real-world application domains, and will also be illuminating to other fields, such as distributed computing and fine-grained complexity. Consequently, we believe this research has the potential of revolutionizing the field of dynamic graph algorithms, and impacting related fields, thus enriching the general landscape of computer science.

Keywords: dynamic graph,dynamic algorithm,optimal algorithm,distributed computing,lower bound
Screen embedded reading glasses - a revolutionary optical technology that eliminates the need for reading glasses while using digital devices. (VISION_GLASS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-05-31
Duration (months): 29.0
Total project cost (EUR): 1287525.0
EU funding (EUR): 899304.0
Participants: 1
Project status: SIGNED

Our groundbreaking solution allows people who suffer of vision impairment to view sharply the screen of any device (smartphone, car display, etc.) without using their glasses. This, among other uses, can allow drivers to put their maximum focus on the road. VISION_GLASS is flexible, thin (less than 0.5mm), transparent foil applied to the display surface comprised of multi layers of tiny invisible micro-optical elements that are used for imaging. This solution will benefit millions of people suffering from presbyopia, and it is possible thanks to our innovative optical technology- Image Projection MLA. VISION_GLASS is a IP-MLA film consists of arrays mutually aligned in a very specific pattern between the positive and negative lenses to form multi–MLA layers of micro-optical elements that create an image at infinity at the user's eye. It is a revolution in the market of reading glasses.

Keywords: digital display innovation,road safety,vision correction,micro lens array,inclusive work environment
Food scarcity and knowledge making: crops and environments in the 18th-century Portuguese and French Atlantic (Scarknow)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Brazil,Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-08-31
Duration (months): 36.0
Total project cost (EUR): 299378.04
EU funding (EUR): 299378.04
Participants: 3
Project status: SIGNED

How to address food scarcity? Scarknow explores the various forms of knowledge mobilised to address scarcity in the Portuguese and French Atlantic in second half of the 18th century. It focuses on two tropical, yet geographically distinct case studies: the French colony of Saint-Domingue, and the northwestern part of the Amazon estuary in Brazil. The question of scarcity was central in 18th-century debates on political economy, a newly founded discipline which had the goal of outlining strategies to produce and increase wealth through the harnessing and transformation of natural resources. Administrators, governors, savants, clergymen, and naturalists all worked to prevent food and crop shortages through grain trade policies and by encouraging the identification of alternative resources in European colonies overseas. But how was the concept of scarcity constructed in ecologies as diverse as Amazonian riverbanks and islands, or the Saint Domingue sugar plantation plains? What kind of knowledge(s) were mobilised to address shortages of dominant crops such as cassava and wheat in non-European geographies? And how were environmental concerns tackled in forms of colonial extractivism and local agricultural practices? This project aims to recover the knowledge and practices—environmental, gendered, hybrid, mechanical and entrepreneurial—developed to address scarcity, along with the actors, European and not, involved in these efforts. It goes beyond a “national Atlantic model”, rather posing transversal questions which underline those hybrid and entangled environmental and knowledge-making dimensions overshadowed by national narratives of empire. The project goes beyond the state of the art by framing the history of scarcity as an Atlantic and environmental history. In doing so, it emphasises the role of indigenous and enslaved communities in cultivation and bread-making, as well as in outlining responses to environmental challenges within colonial economies.

Keywords: environmental history history of knowledge history of latin america early modern