Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TRANSFORMING ACCESS TO EXCELLENCE WITH SUCCESSFUL ALLIANCES OF HIGHER EDUCATION IN DIGITAL AGRICULTURE (TALLHEDA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Serbia,Belgium
Call: European Excellence Initiative (HORIZON-WIDERA-2023-ACCESS-03, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 3716312.14
EU funding (EUR): 3097341.0
Participants: 10
Project status: SIGNED

Widening countries lag behind the European average in Research & Innovation investment and scientific excellence; the domain of Digital Agriculture (DA) is one prominent example. Higher Education Institutes (HEIs) of Widening countries, like Greece and Serbia, can play a central role in addressing this issue, but need support for achieving excellence in research and education in the DA domain. HEIs in Belgium have gained significant experience by establishing an ecosystem that fosters close collaboration among HEIs, competence centers, Digital Innovation Hubs, and industry, leveraging advanced digital technologies for the benefit of citizens, business, and scientific advancement. In this light, TALLHEDA will build a new long-term Alliance for DA between agricultural HEIs from Widening countries with leading non-widening agricultural universities, and local and international stakeholders. TALLHEDA Alliance will contribute to raising the critical mass of highly skilled scientists and to establishing liaisons with surrounding ecosystems, in order to foster the Quadruple Helix of innovation in Widening countries. The path to excellence will be paved with a portfolio of multi-actor, inter-sector and international complementary actions to support students, early-stage and experienced researchers, and academic staff of the Widening HEIs. This will be achieved through collaboration, complementary top-level expertise of all partners, access to cutting-edge infrastructure, staff mobility, and joint educational and research activities. The partners have an established scientific reputation in DA and are committed to making TALLHEDA a success. In the long term, Widening HEIs will be one step closer to reforming their institutions in terms of content and quality of educational courses, pedagogical and management practices, and research and innovation capacity, raising the critical mass of highly skilled scientists needed for digital transition in agriculture across Europe.

Keywords: higher education,agricultural education,digital agriculture,capacity building,innovation hub,multi actor approach,agribusiness,excellence in education,artificial intelligence
Photoionic Light Modulators for Electrochromic Devices (Phides)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The fast increase of telecommunications and technology continuously push towards low energy and complex functionalities. New functionalities necessarily imply silicon technology to be extended to other materials and systems with optical and electrical properties beyond those of Si alone. Optical modulators are one of the principal components constituting photonic circuits directly determine the energy costs and systematic performances of optical devices. Among modulators, electrochromic devices (ECD) regulate light intensity by applying a low voltage. Despite inorganic oxide materials present low energy consumption, limitations arise to fabricate fast switching tunable light EC devices . A possible solution to overcome these limitations are mixed ionic-electronic conductors (MIEC).Their optical properties' change is based on electrochemically driven reversible redox processes regulated by an electric field. Phides aims at developing a novel solid state NV electrochromic devices based on the implementation of rare-earths and strain engineering of functional oxide thin films to tune the change of color contrast and increase switching times. Photo-ionic materials have the potential to deliver robust, fast and energy efficient NV electrochromic devices. However, photo-ionic control is still at an early stage of the R&D process and many aspects still needs to be improved to deliver a competitive device. In essence, Phides will provide: i) An electrochromic guided device based on the electrochemical insertion of oxygen ions; ii) A large and analogically tunable electrochromic response of the cell; ii) A fast electrochromic switching capabilities through the implementation of nanoionics concept for boosting ionic motion; iii) An improved understanding of the oxygen-ion intercalation mechanisms in oxide perovskite thin films; and iv) Device scalability and miniaturization.
A Predictive Coding Perspective of Brain Dynamics: the case of Oscillatory Travelling Waves (OSCI-PRED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1427563.0
EU funding (EUR): 1427563.0
Participants: 1
Project status: SIGNED

One of the most exciting yet puzzling questions in Neuroscience is how the brain coordinates the activity between different areas, integrating distinct representations into conscious percepts and thoughts. For decades neuroscientists have investigated how the brain orchestrates diverse regions’ activity, pointing at oscillations as one of the key mechanisms involved in such a process. However, previous research has mainly focused on the temporal aspect of oscillatory dynamics, largely overlooking how oscillations propagate through the brain. Although rhythmic traveling waves have recently gained renewed interest, their functional role and relation to cognitive functions remain largely unknown. In this project, I will address this fundamental question: what is the role of oscillatory traveling waves in brain dynamics? I plan to take on this challenge using a multi-scale computational approach, modeling neural dynamics within and between cortical regions, as well as cortical-thalamic interactions. Importantly, the novelty of this approach consists in framing the model in the light of Predictive Coding principles, to test the compelling yet striking hypothesis that traveling waves encode Predictions and Prediction-Errors. The results of the simulations will be compared against experimental recordings in human participants to validate and assess the model’s predictions. Lastly, some implementations will turn into deep learning architectures, to test their dynamics in visual tasks while improving current models of artificial vision. All in all, this proposal can significantly advance our understanding of the neurophysiological mechanisms involved in sensory and cognitive functions, testing whether and how oscillatory traveling waves are a critical mechanism in neural dynamics, and producing fundamental results in the scientific field and future technological applications.

Keywords: predictive coding travelling waves brain oscillations deep learning
Epigenetic editing to unravel the causal function of Marks of Active Chromatin: a quantitative and mechanistic dissection (MAChro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

Chromatin modifications are essential for the transcriptional programmes underpinning development and cellular identity. However, an understanding of the causal function(s) of chromatin marks in gene regulation has lagged behind. Particularly, whether chromatin modifications linked with active transcription (active marks) have a causal function remains intensely debated, while the underlying mechanisms are poorly understood. This is due to technical limitations in the ability to precisely perturb chromatin marks in a locus-targeted manner. In this project, I will leverage cutting-edge (epi)genomic tools to systematically dissect the causal roles of key active chromatin marks—H3K4me3, H3/H4ac, and H3K79me2—, at a mechanistic and quantitative level. To directly link locus-specific active mark deposition to transcriptional responses, I will employ a novel epigenome editing technology that allows precise and targeted deposition of chromatin marks. By combining this advanced tool with unbiased genome-wide CRISPR screens using the orthogonal enCas12a system, I will systematically uncover the molecular mechanisms that decode the function of active marks. Additionally, I will dissect the quantitative effects of these marks on transcription at the single-cell level using a tunable epigenetic editing platform. If successful, this proposal will provide unprecedented mechanistic insights into the role of active chromatin marks, paving the way to new therapeutic strategies that harness precise epigenetic control of gene expression.

Keywords: epigenetic editing,crispr,orthogonal crispr screens,chromatin marks,active marks,epigenetic mechanisms of gene activation,degrons,conditional destabilization domains,tunable epigenetic editing
IMPROVING MODELLING METHODS TO PRODUCE CLIMATE SERVICES FOR RESILIENT EUROPEAN SEAS AND COASTS IN A DECADAL TO MULTI-DECADAL HORIZON (RIVIERADE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Italy,France,Netherlands,Germany,Sweden,Belgium,Türkiye
Call: Ocean models for seasonal to decadal regional climate impacts and feedbacks (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4356201.25
EU funding (EUR): 4356201.25
Participants: 11
Project status: SIGNED

Delivering validated climate services for resilient European Sea on a decadal to multi-decadal horizon is a challenge. RIVIERADE brings together the scientific communities geared into CORDEX and the Copernicus Marine Service and capitalizes on their unique scientific experience to develop and implement a pre-operational and replicable multi-model framework and protocols to produce, downscale, assess and deliver state-of-the-art decadal predictions and multi-decadal projections of climate change and related impacts on marine ecosystems, covering the basin scale and the coastal areas, up to, and including, development and demonstration of climate services. RIVIERADE will target three European Seas (Baltic, Black, Mediterranean), to produce data and information for ocean health, sustainable blue economy, and coastal climate risks, downstreaming the data flow from climate ensembles to coastal areas at different spatial resolutions and for selected areas, in a circular process based on users and stakeholders engagement, co-design and assessment of innovative climate services. The proposed methodology will employ high-resolution regional Earth Systems, ocean, marine ecosystem, and impact models of different complexity and will include both traditional and new ocean modelling approaches with the final objective of delivering: (i) coordinated and harmonized multi-model datasets of high-resolution decadal and multi-decadal scenario simulations for the three European target seas (ii) demonstrators of climate services at European Sea basin scale (3 seas), coastal regional (4 subregional areas) and local (4 local use cases) scales. These datasets, together with the framework proposed to produce the coastal climate services, and the portfolio of Delivering validated climate services for resilient European coastal areas on a decadal to multi-decadal horizon represents a challenge in the development of the EU Green Deal and the setting up of reliable digital twins for the ocean.

Keywords: climate ocean services
Bayesian Gutenberg-Richter Analysis for understanding Seismic Processes (B-GRASP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 242593.2
EU funding (EUR): 242593.2
Participants: 2
Project status: SIGNED

Understanding seismic hazard is essential to reducing the risks posed by earthquakes. Our current knowledge comes in part from the study of earthquake nucleation processes and analysing available data on the timing, location and magnitude of past earthquakes. Unfortunately, these seismological observations are limited because we can only detect and use earthquakes above a certain size, making it difficult to estimate critical parameters for probabilistic seismic hazard assessment (PSHA). One of these critical parameters is the b-value, which describes how often earthquakes of different magnitudes occur. Accurate estimation of the spatial and temporal distribution of the b-value is essential for reliable seismic hazard assessment and for understanding the seismic processes that drive seismicity. However, traditional methods for b-value estimation can be biased by subjective decisions, such as which earthquakes to include based on their magnitude. The B-GRASP project aims to overcome these limitations by developing an unbiased, probabilistic method for estimating spatio-temporal variations in b-value. Using original Bayesian approaches, the project will (1) investigate how the b-value changes over time during foreshock sequences and what this reveals about broader seismic processes of earthquake nucleation, and (2) produce updated b-value maps to improve PSHA in regions of low to moderate seismicity, such as Spain and France. The research is highly innovative, taking advantage of recent advances in the use of the b-value, and multidisciplinary, using Bayesian approaches for the first time to achieve better resolution of the b-value and its uncertainties. The results will ultimately be shared with the academic and private sectors involved in the production of seismic hazard maps. This will help to further develop my combined expertise in statistical seismology and seismotectonics, and improve my prospects of securing a permanent research position.

Keywords: seismology,seismic hazard,magnitudes,foreshocks,bayesian methods,seismotectonics
REprogramming Pancreatic Alpha-cells for Insulin production Restoration in diabetes (REPAIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Diabetes affects some 500 million people worldwide (estimated 700 million by 2045), causing over one million deaths annually. The disease results from the loss / dysfunction of pancreatic islet insulin-producing β-cells, leading to chronic hyperglycemia and severe complications. Current treatments are symptomatic and fail to restore long-term glucose regulation, stressing the need for a transformative curative approach. Our proposal leverages α-cell reprogramming as a novel therapy for the restoration of insulin-production in situ, i.e. in the pancreas of diabetics. Islet α-cells remain abundant in diabetic patients and, along with δ- and γ-cells, they possess intrinsic plasticity, meaning that they can “learn” to produce insulin (Nature, 2010 & 2014; Diab Obes Metab, 2016; Nat Cell Biol, 2018; Nat Comm, 2021). Recently, we have shown that if all islet non-β-cells were converted into insulin producers, the islets containing only insulin-producing cells would be perfectly viable and functional, keeping optimal glucose homeostasis (Nat Metab, 2024). We have also reported that genetically reprogrammed human α-cells can secrete insulin and restore normal glucose levels when transplanted to diabetic mice (Nature, 2019). These findings establish islet non-β-cell reprogramming as a viable innovative strategy for diabetes cure. Here, we aim at developing a first-in-class, non-genetic therapy to induce in situ α-cell reprogramming using small molecules. From a targeted screening we identified six FDA-approved compounds that induce insulin expression above a reprogramming threshold in purified α-cells from 2 donors. We will now explore their mechanism of action re the functional conversion and conduct preclinical studies in healthy and diabetic mice to assess reprogramming efficiency in both endogenous and transplanted human cells. If successful, this approach could transform diabetes therapy, offering a safe and clinically viable alternative to current treatments.

Keywords: diabetes,cell dysfunction,cell reprogramming,insulin production,small molecules,islet plasticity,glucose homeostasis,non genetic therapy,fda approved compounds,preclinical studies
Pathways towards non-Abelian physics in moiré materials (Twist2Braid)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1456563.0
EU funding (EUR): 1456563.0
Participants: 1
Project status: SIGNED

One of the most fascinating prospects of two-dimensional quantum systems is the realization of anyons, a unique category of quasiparticles that defy classification as either fermions or bosons, hence transcending the standard model of particle physics. Exploring and manipulating these anyons carries profound fundamental implications and the potential for paradigmatic-shifting technologies. Notably, a subset known as non-Abelian anyons should enable universal and topologically fault-tolerant quantum computations. Traditionally, the search for these anyons has focused on quantum Hall systems, where the strong magnetic fields required to stabilize them have significantly hindered advances in their characterization and manipulation. In the last year, groundbreaking experiments on twisted moiré bilayers successfully realized fractional Chern insulators, serving as zero-field analogs of quantum Hall states where anyons can naturally occur. I present the Twist2Braid project to capitalize on the advancements from these pioneering experiments and unlock the promises offered by non-Abelian anyons. My proposal is structured around three key pillars: (1) identifying ideal moiré heterostructures through a high-throughput search over two-dimensional materials and their stacking and twisting configurations; (2) modeling topological moiré materials and predicting experimental signatures indicative of anyonic physics; and (3) designing new systems acting as traps for non-Abelian anyons using both interfaces between topologically ordered phases and proximity with superconductors. To achieve the latter two objectives, I will develop innovative variational numerical methods that overcome the limitations of state-of-the-art computational techniques and allow simultaneous access to the bulk and edge properties of systems under consideration.

Keywords: topological phases,anyons,moir materials,two dimension,strongly correlated quantum systems
Virtualisation and Multimodal Exploration of Heritage on Nazi Persecution (MEMORISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Denmark,Netherlands,Austria,Czechia,Israel,Spain,Germany
Call: Preserving and enhancing cultural heritage with advanced digital technologies (HORIZON-CL2-2021-HERITAGE-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3975427.11
EU funding (EUR): 3975427.11
Participants: 11
Project status: SIGNED

Heritage related to Nazi Persecution (HNP) appears in various forms such as diaries, letters and testimonies that capture memories of eyewitnesses, or registers like death records, deportation statistics and historical photographs that provide important contextual information to these memories. MEMORISE will create a framework to preserve and enhance HNP by virtualising and linking multimodal HNP data resources and by developing and offering novel digital technologies to the general public for accessing, exploring and engaging with HNP. The heart of MEMORISE will be an HNP infrastructure to assist consortial and associated memorial sites and archives in processing 80,000+ HNP content items to make them persistently accessible to the public. We will develop a suite of digital tools for presenting, narrating and engaging with HNP data including a web-based HNP platform for unguided exploration, an HNP reader to support comparative readings as well as three on-site and virtual learning interfaces to support general public users in interacting with HNP in new ways. To generate individualised experiences for these interfaces, MEMORISE will develop a user model and an AI engine for individualised content based on user behavior and preferences. Semi-automated AI-based services will be a major component of our data processing pipeline to feed Dutch, English and German HNP materials into the HNP infrastructure. We will develop an educational concept to evaluate the benefits and limitations of our user interfaces for learning on and engaging with HNP in on-site and virtual visits, especially in times of a pandemic with relevance for a large array of adjacent memorial sites and creative industries. Our social media concept will target engaging digital native generations to explore HNP. To exploit our results, we will develop an intersectional toolkit including best-practices to accelerate the use of digital tools in cultural heritage and adjacent cultural industries.

Keywords: heritage on nazi persecution,user interfaces for education,visual exploration,3d modeling,ai based recommendations,narration,individual experience,born digital data,comparative research