Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the genetic encoding of dynamic interactions underlying transcriptional regulation (GPIDR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-15
End date: 2024-07-14
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Transcription factors often serve as key hubs for dynamic protein-protein interactions in eukaryotic cells. Aside from their characteristic DNA binding domains, the vast majority of transcription factors contain activation domains that are often intrinsically disordered. These domains are not well-characterized, but are thought to contain key sequence-distributed features that enable transcription factors to interact with their many binding partners, and have recently been associated with the capacity to form transcriptional condensates through phase separation. Many questions remain about how genotype and phenotype are related in these relatively uncharacterized regions, particularly with respect to their dynamic binding interactions, with important implications for human disease-associated mutations. Here, we propose to help uncover the relationships between sequence, structure, and dynamics of these interactions in vivo, using the power of deep mutational scanning and protein complementation assays in budding yeast.

Keywords: deep mutational scanning,intrinsically disordered
Safe Hydrogen Injection Modelling and Management for European gas network Resilience (SHIMMER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Spain,Italy,Poland,Netherlands,Germany,Belgium
Call: Safe hydrogen injection management at network-wide level: towards European gas sector transition (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 3037265.0
EU funding (EUR): 2999156.25
Participants: 14
Project status: SIGNED

To accelerate the transition to a low-carbon economy while exploiting existing infrastructure, hydrogen can be injected to the natural gas network. However, the there are many technical and regulatory gaps that should be closed and adaptations and investments to be made to assure that multi-gas networks across Europe will be able to operate in a reliable and safe way while providing a highly controllable gas quality and required energy demand. Recently, the European Committee for Standardization concluded the impossibility of setting a common limiting value for hydrogen into the European gas infrastructure recommending a case-by-case analysis. In addition to this, there are still uncertainties related to material integrity on pipelines and networks components with regards to a reduced lifetime in presence of hydrogen. Existent results from previous and ongoing projects on the hydrogen readiness of grid components should be summarized in a systematic manner together with the assessment of the existent T&D infrastructure components at European level to provide stakeholders with decision support and risk reduction information to drive future investments and the development of regulations and standards. The SHIMMER project aims to enable a higher integration and safer hydrogen injection management in multi-gas networks by contributing to the knowledge and better understanding of hydrogen projects, their risks, and opportunities. - To map and address European gas T&D infrastructure in relation to materials, components, technology, and their readiness for hydrogen blends - To define methods, tools and technologies for multi-gas network management and quality tracking, including simulation, prediction, and safe management of transients, in view of widespread hydrogen injection in a context of European-wide context -To propose best practice guidelines for handling the safety of hydrogen in the natural gas infrastructure, managing the risks

Keywords: hydrogen,natural gas,gas networks,low carbon economy,flow modelling,material technology,infrastructure retrofitting and repurposing
Non-Invasive Predictive Modelling of Amphibian and Pathogen Diversity (NIPMAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-04-30
Duration (months): 26.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 3
Project status: CLOSED

The current global biodiversity crisis requires rapid, inexpensive and reliable methods of detecting the main threats to species’ survival: pathogens, habitat change, and loss of genetic diversity1. Equally crucial are solutions for stemming biodiversity loss: we lack vital models that determine how these threats interact, which would help prioritise conservation efforts. Recently, CRI-CG has discovered for one species of frog over a relatively small geographic area that eDNA extracted from water samples captures more genetic diversity than analyses using tissue samples (UNESCO-funded project ACQUAVIVA). The same eDNA can be used to detect amphibian pathogens. NIPMAP will apply this knowledge in an innovative way by: i) optimizing this eDNA approach to estimate mtDNA diversity in four amphibian taxa (two caudates, two anurans) and pathogen diversity (principal pathogens: Bd, Bsal, Rv) across the eastern Italian Alps; ii) using these data to inform individual-based and spatially explicit simulations of host movements and pathogen transmission37; iii) integrating parameters from i-ii with skin microbiota and other health indices, as well as iv) environmental variables at each sample site, to generate correlative models (e.g. GLMMs and SDMs) and potential distribution maps to direct conservation management decisions. We will also pilot two innovative eDNA protocols: one to measure nuclear DNA diversity (to measure current gene flow and dispersal rates) and one to understand microbiota function using metatranscriptomics. These interdisciplinary tools will be integrated into a workflow that will be applicable to animal taxa anywhere on the planet.

Keywords: non invasive sampling,microbiota,pathogen ecology,
Minimisation of the offshore wind and tidal turbine acoustic footprint on marine life (off-coustics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1992500.0
EU funding (EUR): 1992500.0
Participants: 1
Project status: SIGNED

For renewable energies to be sustainable in the future, their impact and harmful effects on the environment should be minimum. Recent evidences suggest that offshore wind and tidal turbines can have an acoustic damaging impact on marine life, due to the sustained generation of noise, which propagates very efficiently underwater. Off-coustics combines numerical simulations and experiments to provide insights into the physics governing the aero/hydro-acoustic generation and propagation for offshore wind and tidal farms. Control of these physics will enable the design of silent offshore farms enabling renewable energy with zero acoustic impact. First, I propose to develop a novel aero/hydro-acoustic solver, blending advanced high order numerical techniques through machine learning and trained with experiments, to simulate flow-acoustic signatures for wind and tidal turbines, in realistic offshore environments (including bathymetry, air-water surface, etc.). Second, an experimental campaign will generate aero/hydro-acoustic data for scaled turbines and farms to help elucidate the physics governing offshore acoustics and to guide/validate the flow-acoustic simulator. Third, simulations and experiments will be combined to characterise turbines in complex offshore environments and to develop physic-informed surrogate models. Fourth, using the developed surrogate models and optimisation, Off-coustics will propose new designs of silent farms that minimise the acoustic impact while ensuring energy production. Major advances in multidisciplinary aspects are expected, including fluid mechanics, numerical simulations, optimisation, experimental acoustics, aero/hydro-acoustics and offshore wind and tidal turbine physics.

Keywords: computational fluid dynamics,high order methods,optimisation,machine learning,offshore wind turbines,tidal turbines,acoustics
Deciphering de novo gene birth in populations (NovoGenePop)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 2453751.0
EU funding (EUR): 2453751.0
Participants: 1
Project status: SIGNED

Genes are fundamental units of life and their origin has fascinated researchers since the beginning of the molecular era. Many of the studies on the formation of new genes in genomes have focused on gene duplication and subsequent divergence of the two gene copies. But, in recent years, we have learnt that genes can also arise de novo from previously non-genic sequences. The discovery of de novo genes has become possible by the sequencing of complete genomes and the comparison of gene sets between closely related species. Here we wish to test a novel hypothesis, we propose that de novo gene formation dynamics in populations results in substantial differences in gene content between individuals. If they exist, these differences would be not be visible by the current methods to study gene variation, which are based on the comparison of the sequences of each individual to a common set of reference genes. To test our hypothesis, we will need to develop novel computational approaches to first obtain an accurate representation of all transcripts and translated open reading frames in each individual, and then integrate the information at the population level. We propose to apply these methods to two very distinct biological systems, a large collection of Saccharomyces cerevisiae world isolates and a human lymphoblastoid cell line (LCL) panel. For this, we will collect and generate RNA (RNA-Seq) and ribosome profiling (Ribo-Seq) sequencing data. In order to identify de novo originated events occurred within populations, as opposed to phylogenetically conserved genes that have been lost in some individuals, we will also generate similar data from a set of closely related species in each of the two systems. Combined with genomics data, we will identify the spectrum of mutations associated with de novo gene birth with an unprecedented level of detail and uncover footprints of adaptation linked to the birth of new genes.

Keywords: molecular evolution
Power-to-X: STREAMing Hydrogen from 3-Band Solar Cells boosted with Photonic Management (X-STREAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999608.0
EU funding (EUR): 1999608.0
Participants: 1
Project status: SIGNED

X-STREAM will sprout a new era of sustainable power sources based in photovoltaic (PV) systems which are not bounded by fundamental limits that hamper the efficiency of conventional solar cells, and endowed with energy storage via a synergetic coupling with electrochemistry (EC). This will be achieved via an unprecedented energy-package integrating two disruptive advances: 1) Light management via quantum structuring amplified by photonic trapping, to create 3-band PV – a new trend that will be launched, realized with wide-bandgap nanostructured solar cells capable of pronouncedly converting photon energies below their bandgap, thus exploiting the broad solar spectral range. This will allow, for the first time, to increase the efficiency of single-junction PV towards a 50% theoretical maximum, which is close to the limiting efficiency of triple-junction cells but here is attained with a single-junction. 2) Smart combination between PV cells and EC flow cells, in compact PV-EC devices that deliver the energy in hydrogen (H2) fuel synthesized from water splitting, enabling close to 30% solar-to-H2 efficiency with high operation stability, by capitalizing on: a) high voltage per junction of the 3-band PV technology, which is favourable to drive the EC reactions; b) thermal coupling between PV and EC in single devices, which naturally provides heat management of both systems. The targeted fuel is a highly convenient energy vector in view of the present European urgency for a resilient, competitive and environment-friendly H2 economy. All the project developments will be attractive for industrial deployment, since mostly Earth-abundant materials and scalable processes are applied, so that the PV-EC prototypes can be easily customized and scaled for different uses. The expertise of the PI team and his network of collaborators in nanotechnology, multi-band PV, photonics for light-trapping and solar fuels via PV-EC, places him in the best position to realize X-STREAM goals.

Keywords: solar fuels,photovoltaics,green hydrogen,multi band semiconductors,photonics for light management,nanostructured perovskite solar cells,solar powered electrochemical water splitting
Inhibitors of ECF transporters as novel antibacterial agents (InECFAb)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance is a global health threat, urgently calling for the development of novel anti-infective strategies. We will adopt a multidisciplinary approach to design, synthesize and optimize derivatives targeting ECF transporters as antibacterial agents. The ECF transporters are transmembrane proteins involved in the uptake of vitamins predominantly in Gram-positive pathogens (e.g., Streptococcus pneumoniae, Enterococcus faecalis, E. faecium, Staphylococcus aureus). Their inhibition prevents the uptake of vitamins from the environment, leading to starvation followed by cell death. Due to their critical role in the homeostasis of vitamins in bacteria as well as their absence in humans, ECF transporters are considered a promising novel antimicrobial target. We will thoroughly profile our inhibitors for their in vitro on-target and antibacterial activities. We will, on the one hand, further validate the cellular target through advanced target engagement studies and attempt to achieve a co-crystal structure using cryo-electron microscopy. Furthermore, evaluation of the inhibitors for their in vitro ADME-T properties and in vivo pharmacokinetic profiles will set the stage for in vivo infection models in mice. The extensive data that we will gather will enable us to nominate the most promising compound(s) for further multiparameter optimization en route to the nomination of a preclinical candidate. Ultimately, this opens access to novel anti-infectives with an unprecedented mode of action.
Controlling Pervasive Transcription (PervasiveTranscript)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

The human genome is pervasively transcribed, producing RNA from ~ 80-90% of its DNA, yet only a small fraction of transcripts result in the generation of functional RNAs. Instead, the majority of transcription initiation events are prematurely terminated and the resulting RNA is targeted by decay pathways. How cells ‘determine’ which RNAs to degrade vs. which to prepare for functional tasks, is a central question. Interestingly, new data from my host laboratory, that motivates this application, suggest that non-productive transcription events are correlated with low transcription initiation levels; i.e. lowly transcribed RNAs appear to be more susceptible to early termination and ensuing rapid degradation. Transcription termination in these instances is conducted by either Integrator (INT) complex or components interacting with ARS2 transcription termination factor. In the present project, I will investigate the mechanisms underlying this relationship, which could possibly rationalize how cells keep their spurious transcription under control. Considering the association of INT and ARS2 mutations with cancer and neurological diseases, my results might also pave the way for therapeutic interventions. Previous approaches utilizing targeted transcription repression/activation by CRISPRi/a approach are based on absolute On/Off transcription from the selected loci without the ability to fine-tune the transcription at a predicted level. Here, I will utilise newly reported mismatch guide RNA/CRISPR-dCas9 to manipulate initiation to defined levels and hereby establish a tuneable system to assay the fate of RNAs expressed from weaker vs. stronger promoters. I will then exploit this system to address the molecular mechanism, dictating genome control based on transcription initiation levels. The findings of my project will be of interest to many disciplines of the scientific community in that it might help explain how genome expression is sorted at a higher order level.

Keywords: early transcription termination,pervasive transcription,rna decay
A look inside: domestic features and the implementation of human and environmental risk measures in European Antarctic Treaty Parties (POLARPOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-09
End date: 2025-08-08
Duration (months): 26.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

The Antarctic Treaty has successfully overcome sovereignty disputes in the region by ensuring governance based on peace, scientific cooperation and environmental protection. But there are limits to its domestic implementation. Since 2004, the Treaty Measures 4 (2004) and 1 (2005) managing human and environmental risks in Antarctica have not become effective because not all Treaty Parties have implemented them. To find out what affects the implementation by Treaty Parties, I will compare 12 European Antarctic National Programmes to identify which domestic factors foster or delay the implementation of these measures. I will analyse documents, interview national Antarctic policy actors, and use Process Tracing and Qualitative Comparative Analysis for a comparative conclusion and for recommendations on how Parties should foster the Measures' implementation. Results will advance the field of multilateral environmental agreements, showing the implications of domestic differences for Antarctic governance; and they will help stakeholders to reshape their expectations of the Treaty’s future development. Moreover, by comparing different European Antarctic Treaty Parties, this project will also help to establish a European Antarctic perspective, which is still underdeveloped. The host institution, Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI), is one of the world’s leading institutes in Antarctic research. I will be integrated in AWI's International Cooperation Unit, where I will acquire contact with most European National Antarctic Programmes, and a Secondment at the European Polar Board in The Hague, the Netherlands, will provide me with data about the different European National Antarctic Programmes. POLARPOL will thus help me to develop myself as a consummate researcher in environmental governance and multilevel policy analysis and to establish myself as a competent policy advisor for the Polar regions.

Keywords: antarctic treaty environmental governance international regimes implementation policymaking
Unlocking serial Aluminium Additive Manufacturing with Molten Metal Deposition technology (MMD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 3571411.25
EU funding (EUR): 2499987.88
Participants: 1
Project status: SIGNED

High-strength, lightweight and conductivity are properties that set aluminum apart as the 2nd widely used metal in the world. Mechanical manufacturing techniques like CNC milling or die casting are industry standards for mass production of industrial parts. However, when it comes to additive manufacturing (AM) to increase the complexity of the parts there is no existing AM technology for serial runs or on-demand/spare parts at competitive speeds and costs. ValCUN fills the gap for complex aluminum parts to deliver the most economical, fastest and energy-efficient AM technology, ready for serial production. Molten Metal Deposition (MMD) is our unique single-step metal additive manufacturing technology, with initial focus on aluminum. Unlike powder- and laser-based AM techniques (DED, LPBF, FDM/MIM), we produce parts directly with liquid metal from aluminum wire feedstock as a paradigm-shift in metal AM to reduce production costs by 75% while being 10x faster and allowing high degree of automation for 1-10k serial batch production with minimal post-processing.

Keywords: aluminium additive manufacturing,liquid metal 3d printing,high strength alloys,molten metal deposition