Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ion-gated Interfaces for Quantum Phase Devices (Ig-QPD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The aim of this ERC proposal is to develop a highly efficient tunable interface with ion-movement-mediated gating as a rich platform for novel electronic devices by using field effect controlling of quantum phase transitions. Working beyond conventional FETs, the new transistors will be build by combining novel layered semiconductor films grown by the CVD method: newly synthesized ionic material; and a well-defined interface optimized by surface analysis techniques; which jointly are able to boost the field effect control of carrier doping to the range required for switching quantum phases such as superconductivity in electrical transport, ferromagnetism in magnetization, and chiral or coherent light sources in optical applications. The sub-topics are designed to cover sufficiently broad disciplines of material sciences, new device technologies based on electrochemical principles, and condensed-matter physics. Such a design will make the project high adaptable for success at different levels with clear defined objectives to: 1) develop new materials and material combinations for ion gated interfaces to establish a rich platform of quantum phases; 2) utilize these quantum phases for device functionalities enjoying the characteristic abrupt response in phase transitions and to establish control of magnetism by field effect; and 3) create light emitting devices for effectively correlating light emission with quantum phases. The project represents an exciting new research field that is attracting the attention of many research groups around the world. The applicant is a well-established pioneer in developing this rapid growing and highly competitive field, where he achieved major milestones in design, fabrication and operation of quantum phase devices. Embedded in the strong material researches environment of the host institute and in his new group, it is the perfect timing for the applicant to fulfil the dream of creating a new paradigm of electronic devices.

Keywords: field effect transistor,2d layered materials,superconductivity,quantum phase transition
Isis, Images and Agency. The Creation, Use and Perception of Religious Iconography Concerning the Egyptian Gods in the Hellenistic and Roman Worlds (IsImAg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

In the Hellenistic and Roman worlds, the Egyptian goddess Isis was remarkably popular along with the deities related to her, such as Sarapis, Harpocrates and Anubis. Tens of thousands of objects, from a wide variety of contexts and periods, convey images that attest to the immense success of these cults. Both rich and coherent, this corpus of transcultural imagery provides an excellent laboratory for the study of the creation, use and perception of ancient figurative media, especially in terms of agency. Previous research on this religious iconography has only wielded a fragmented vision, paying little attention to contexts and media. However, these images can only be understood in relation to one another and as part of their sociocultural and religious networks. Since 2013, reconstituting this overview has been the aim of a Thesaurus whose catalogues gather all Isiac images for every kind of medium, highlighting the contextualised objects and questioning what they meant and did. The progress of this collective undertaking allows me now to present a research project crucial to many categories of historians working on visual (material) culture. By reconstituting the history of Isiac images throughout various types of production, the Thesaurus demonstrates how figurative systems were constantly interacting and evolving during Antiquity. It enables us to ask new questions on the creation, use and perception of these object-images from both a synchronic and diachronic perspective. The synthesis emerging will form a "historical grammar" revealing the functioning of this figurative culture and its impact on ancient societies. With the largest part of the Thesaurus now available, Leiden University provides the best current academic context for the more interpretative and synthesising parts of the research. By partaking in a more conceptual research culture, this experience will have a decisive impact on my scientific development and will open up numerous new perspectives.

Keywords: classical world,hellenistic and imperial ages,visual culture,object images,polymorphy,polysemy,figurative systems,polytheisms,egyptian gods,isiac cults,agency,contexts
Unrestricted Divide-Expand-Consolidate Coupled Cluster Methods for Large Open-Shell Molecules (DECOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Computational chemistry is a modern and multidisciplinary subject, which underpins many areas of chemistry, physics, biology and material science. Due to recent advances in both theory and computational facilities, it is now quite clear that computational chemistry has reached the point where it should be considered as an equal partner to experiment and that in some cases it may even guide and unite the experimental efforts across multiple scientific disciplines. The proposed “DECOS” project (Unrestricted Divide-Expand-Consolidate Coupled Cluster Methods for Large Open-Shell Molecules), addresses one of the most challenging problems of contemporary computational chemistry: the ability of theoretical modeling to describe accurately large open-shell systems (molecules with one or more unpaired electrons) at affordable computational costs. To this end the Divide-Expand-Consolidate (DEC) scheme must be extended to unrestricted formalism. The new method constitutes crucial breakthrough because it combines linear scaling and rigorous error control of the established DEC scheme with the ability of treating large open-shell systems for biological and industrial use. Indeed, magnetic and catalytic properties, reactivity and spectroscopy often must be entirely attributed to special electronic structure of the open-shell systems. Additionally, through collaboration with Oak Ridge National Laboratory, the new methods will be implemented, tested and run on “TITAN” – one of the largest super computers in the world. Besides cutting edge science proposed in the project, it will also become a crucial step towards reaching professional maturity and independence in the applicant’s career. The project has potential for creating broad scientific impact and to establish long-term collaborations. Also, it assures the new knowledge will be secured, transferred and applied fully. The proposed developments will likewise be used and maintained for many years beyond the lifetime of the grant.

Keywords: linear scaling,coupled cluster methods,open shell systems,first order molecular properties,molecular orbitals localization,ccsd,divide expand consolidate scheme
New directions in bicyclopentane research (BCPPlus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-16
End date: 2020-07-15
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The pharmaceutical industry is increasingly seeking new tactics for the structural modification of drug candidates to avoid metabolic susceptibility, or to improve pharmacokinetic properties. Analogues called 'bioisosteres', which mimic the dimensions and substituent directionality of problematic structural motifs, but which are not themselves subject to the same pharmacological issues, offer one solution. Often based on scaffolds not found in ‘typical’ drug candidates, bioisosteres can additionally occupy new areas of intellectual property space. Within this growing field, rigid polycycles such as bicyclo[1.1.1]pentane (BCP) are receiving significant attention as arene bioisosteres, as they exhibit similar ring diameters and substituent positioning, and also improve many pharmacokinetic properties relative to the parent arene. Despite the attractive nature of these motifs and current interest, the lack of general routes to complex BCP ring systems means this template is not yet fully accessible to industry. The invention of mild methods for [1.1.1.0]tricyclopentane (TCP) ring opening and functionalization could revolutionize use of BCPs in the pharmaceutical sector. One method not explored to date is an atom transfer radical addition reaction (ATRA) strategy. Using aryl or alkyl halides, ATRA could deliver an abundance of previously inaccessible polysubstituted BCPs from generalized TCP, which would revolutionize this immature, cutting-edge area of organic and medicinal chemistry. This research proposal seeks to: i) explore general and mild ATRA-based syntheses of BCP derivatives, including ring-expanded (hetero)bioisosteres; ii) functionalize BCP products using a range of contemporary processes, including C–H or C–X activation; and iii) apply these methodologies to synthesize BCP drugs / natural product analogues, and to test their biological activity via an industrial collaboration.

Keywords: bicyclopentanes,bioisostere,atra,radical chemistry,c h activation,photoredox,iron catalysed cross coupling,artificial amino acid,peptide drugs
Novel insights into sex-specific and oestrogen-dependent mechanisms in myocardial ischaemia/reperfusion injury (SEXOGENIRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Iceland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 294359.04
EU funding (EUR): 294359.04
Participants: 1
Project status: CLOSED

Acute myocardial infarction (MI) accounts for millions of morbidity and mortality cases worldwide. While the underlying pathophysiology of cardiomyocyte dysfunction and death during MI-related ischaemia/reperfusion injury (IRI), which occurs due to the restoration of coronary blood flow after MI, is well established, the relevance of sex-based differences in this context is poorly understood. In this action, we aim at understanding the effect of biological sex in the induction of a novel form of cell death in the setting of IRI. The project will examine both mouse and human hearts and will benefit from a range of techniques including, but not limited to in vivo surgery, in vitro cell line evaluation, state-of-the-art microscopy, mitochondrial respirometry and molecular biology methods. The content of the action will enable the researcher to restart his career and gain important academic, interpersonal and laboratory skills. It will also provide an opportunity for the researcher to publish in major journals and disseminate his findings to scientists and the public, which will ultimately help him establish himself in the field of cardiovascular science. The action also helps raise the research and academic profile of the host team and institution and contribute to the development of strong intra-European science networking. Overall, this action aims at contributing to the scientific progress of the researcher and pave the way for the identification of novel therapeutic targets for IRI with direct translational potential.

Keywords: cardiac,cell death,mitochondria
From Bulk to Edge: Realization and Characterization of Fractionalized Quantum Matter (sharpEDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2020-09-30
Duration (months): 36.0
Total project cost (EUR): 246668.4
EU funding (EUR): 215699.4
Participants: 3
Project status: CLOSED

Most phases of matter can be understood using the concept of symmetry breaking. For example, the organization of water molecules in an ice crystal breaks the continuous translational symmetries that are preserved in liquid water. The discovery of the quantum Hall effect triggered a revolution of this concept. It was the first example of topological order, a type of order that cannot be detected with any local measurement and supports exciting new properties. A striking example is the universal transport properties which are so robust that metrologists use them to define the quantum of conductance. Additionally, exotic particles with fractionalized quantum numbers called anyons may emerge as collective excitations of these systems and could provide a route to fault-tolerant quantum computing. Despite the increasingly good theoretical understanding of fractionalized phases, there is a strong need to relate the theories to experimentally relevant models. sharpEDGE will build new bridges between the effective and microscopic descriptions of fractionalized phases of matter. This requires us to solve a cumbersome quantum many-body problem. Numerical methods are essential here: they have accompanied the progress of the field since its early days, and the most recent developments give hope to solve some long-standing issues. We will thus apply a multidisciplinary approach combining the latest advances in topological quantum field theory, quantum information, and material science. Fractionalization may occur in gapped systems such as the fractional quantum Hall effect, lattice topological insulators or frustrated magnets, but also in exotic metallic phases. In this context, we will explore the microscopic relation between the edge and the bulk of gapped topological phases, and develop new characterization tools for gapless phases.

Keywords: topological phases,fractionalization,spin liquids,non fermi liquid,fractional quantum hall effect
Discovery and functional significance of post-translational N-terminal acetylation (NterAct)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 1999273.0
EU funding (EUR): 1999273.0
Participants: 1
Project status: SIGNED

In mammalian cells, N-terminal (Nt) acetylation is one of the most abundant protein modifications. It is catalysed by N-terminal acetyltransferases (NATs) and mostly occurs co-translationally. However, in contrast to the defined co-translational NATs, post-translational NATs which have crucial regulatory roles are mostly unexplored. Distinct peptide hormones regulate appetite, metabolism, sexual behaviour and pain, and their biological activity is critically modulated by post-translational Nt-acetylation. However, the identity of the NAT responsible for this modification, ‘HormNat’, is unknown, thus the molecular and physiological ramifications of this regulatory circuit remain elusive. Another example is actin, a key regulator of cell motility and cell division. The actin N-terminus is crucial for actin function and in mammals actin is modified by an unknown post-translational NAT, ‘ActNat’. Hence, the objectives of this project are to identify these human NATs acting post-translationally, and to investigate their molecular mechanisms, regulation and impact. We will identify the novel NATs by a combination of classical and newly developed in-house tools like in vitro acetylation assays, unique bisubstrate analogues, Nt-acetylation specific antibodies, and targeted mass spectrometry. Interestingly, Nt-acetylation is considered irreversible, but there is reason to believe that specific substrates are Nt-deacetylated. Elucidation of post-translational NATs and the reversible nature of Nt-acetylation would represent a new era in the field of protein and peptide regulation and identify key cellular and organismal switches.

Keywords: acetylation,acetyltransferase,peptide hormone,cytoskeleton,actin,pomc
Evaluation of the Benefits of innovative Concepts of laminar nacelle and HTP installed on a business jet configuration (BinCola)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Germany
Call: Evaluation of the benefits of a laminar nacelle and a laminar HTTP installed on a bizjet configuration (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2020-02-29
Duration (months): 16.0
Total project cost (EUR): 1555576.25
EU funding (EUR): 1555576.25
Participants: 3
Project status: CLOSED

The global target of the project “BinCola” is the experimental verification of benefits coming along with the replacement of classically designed nacelles and HTP by enhanced components specifically developed for natural laminar flow (NLF) development. To ensure a realistic evaluation and assessment of benefits relevant wind tunnel tests will be performed at flight Mach and Reynolds numbers. An existing basic model of a business jet configuration will be made available by the Topic Manager and serve as the reference configuration. He is also responsible for the provision of the laminar design of the components to be replaced while their detailed design, manufacturing and assembly are part of this proposal. Transition monitoring is generally performed at cryogenic conditions by using temperature sensitive paint (TSP). To visualize laminar and turbulent areas a positive or negative temperature step has to be performed in a wind tunnel violating by nature the consistency of all flow parameters. New developments at ETW and DLR offer to overcome this deficit by innovative surface heating concepts which are proposed here for application. This approach will make temperature steps superfluous; hence, allow taking images during continuous incidence polars, the standard testing sequence in ETW

Keywords: natural laminar flow,temperature sensitive paint,innovative concepts,nacelle,cnt carbon nano tubes,laser heating,biz jet
Power in Low Earth Orbit. Verified. (LEOpowver)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2022-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

More than 17,000 satellites are announced for launch into Low Earth Orbit (LEO) before 2027, for the purpose of real-time Earth observation and worldwide connectivity. The multitude of mission initiatives is a sign of democratization of space and induces enormous business opportunities. LEOpowver will harvest results of the ERC Advanced Grant POWVER for the LEO market to arrive at orbit-proof software for the continuous, fully automated, power-optimal and profit maximising dynamic operation of Low Earth Satellite Constellations. The software will solve the pivotal challenge in the software-driven orchestration of satellite constellations, namely the management of the severely limited in-orbit electric power budget. + At any point in time a highly accurate power model approximates the actual distribution of the state-of-charge of the on-board batteries very tightly. This enables tracking and extrapolation of the battery state with unprecedented accuracy. + Data transfer needs within large satellite constellations induce critical interdependencies between the individual satellites' power budgets. The LEOpowver software determines the optimal data transfer in the form of a contact plan, enabling the constellation-wide best utilisation of resources while provably minimizing battery depletion risks. + In-orbit battery measurements are transmitted to ground at the earliest possible moments, where they are fed into a machine learning mechanism rectifying the on-ground models of the satellites, which in turn is the basis for perpetuating the computation of always safe and best-to-follow receding-horizon schedules in a self-adaptive manner. In this way, the quality of the constellation management is continually improved. The central activities of LEOpowver are (i) in-orbit validation of this software on a LEO satellite constellation and (ii) in-depth exploration of commercialisation opportunities for the software product.

Keywords: low earth orbit,networked satellite constellations,contact plans,kinetic battery model,optimisation,in orbit validation,commercialisation