Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Open-Source Proxy Tool for CO2 Injection and Storage Modeling - Sustainable Utilization of the Norwegian Continental Shelf (OSPT-CISM-SUNCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-05
End date: 2026-12-04
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: CLOSED

Geological CO2 sequestration has gotten a lot of attention as a potential technical solution for decreasing human carbon emissions to the environment. Numerical reservoir simulation (NRS) has been conventionally used to model subsurface reservoirs and employed in uncertainty analysis, optimization, and decision-making. One of the challenges associated with NRS is the computational efforts required to model complex reservoir systems. Therefore, fast proxy models are suggested for quick predictions. Although several studies have been conducted about the CO2 injection & storage (CIS) process, there still exists a research gap in developing a fast tool for monitoring and performance prediction of a safe CIS project. This research project aims to develop an open-access smart tool to predict the performance of CIS with satisfactory accuracy in the mature fields of the Norwegian Continental Shelf, considering geochemical & geomechanical (GCGM) aspects. The uncertainty parameters will be the underground rock and fluid properties, operational constraints of the CO2 injection, and GCGM parameters. The target parameters include net CO2 storage, ultimate oil recovery from miscible CO2 injection, & cumulative production of gaseous CO2. The risk of CO2 leakage through induced fractures/faults should be considered by considering the effect of GCGM parameters on CIS. The effect of GCGM parameters on such processes will be useful in CO2 leakage risk quantification, making the proxy model more realistic. Machine learning tools, such as PINN, ANN, SVR, and XGBoost, will be applied to the simulated data set to digitalize the CIS process efficiently. The developed proxy model will be validated with a synthetic truth model. Lastly, the novel proxy model will be added as a separate module to MRST - an open-access software. This integration offers researchers and industry professionals an openly accessible, fast & accurate proxy model to streamline the initial evaluation of CIS projects.

Keywords: machine learning,proxy modeling,geological carbon sequestration,co2 storage,co2 enhanced oil recovery,norwegian continental shelf
Quantitative HYpoxia imaging for charged ParticlE Radiation treatment guidance: an improved strategy for Aggressive brain Cancers Treatment (HYPERACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

Glioblastoma and skull base chordoma are two of the most aggressive types of brain cancers and have an extremely poor prognosis, with most tumours recurring within months of surgical and chemoradiation treatments. Recurrence is caused by tumour heterogeneity, as regions of the tumour with different biological properties respond differently to treatment. Tumour hypoxia (low oxygenation) is the leading cause of resistance to radiotherapy in heterogeneous cancers and is linked to poor patient prognosis. Effectively counteracting tumour hypoxia requires delivering higher doses of radiation selectively to hypoxic tumour regions. This is hard to achieve with conventional radiation treatment, where a uniform moderate radiation dose is delivered to the entire tumour target and dose-escalation strategies are limited by toxicity constraints established to limit damage to important surrounding brain structures. Standard radiotherapy plans do not incorporate any measure of tumour hypoxia, due to limitations in imaging techniques currently used for planning. The work proposed in this fellowship aims to improve radiation treatment for heterogeneous cancers by combining quantitative MRI/PET imaging, to non-invasively characterise regions of tumour hypoxia, and carbon ions radiotherapy, to deliver higher doses of radiation to those regions, whilst sparing surrounding healthy tissue. This strategy will deliver a more effective radiation dose distribution, providing an opportunity to improve local tumour control and patients’ survival outcomes and quality of life.

Keywords: quantitative mri,mri guided radiotherapy,charged particle radiation therapy,brain tumours,radiation oncology
Science for Policy by European Academies (SAPEA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Euratom
Destination: Euratom
Action type: Coordination and support actions
Countries involved: Germany,United Kingdom,Austria,France,Belgium
Call: Science Advice for Policy by European Academies (SAPEA 3) (HORIZON-EURATOM-2024-SAPEA-IBA, 2024)
Start date: 2025-01-01
End date: 2029-04-30
Duration (months): 52.0
Total project cost (EUR): 8000000.0
EU funding (EUR): 8000000.0
Participants: 8
Project status: SIGNED

“Science Advice for Policy by European Academies” (SAPEA) is part of the Scientific Advice Mechanism to the European Commission, which provides independent scientific evidence and policy recommendations to the European institutions by request of the College of Commissioners. SAPEA’s role is to provide independent, high-quality evidence reviews to inform policy recommendations made by the Group of Chief Scientific Advisors. To achieve this, SAPEA assembles interdisciplinary working groups of scientific experts, supported by systematic literature reviews. SAPEA is a consortium of the six European Academy Networks — Academia Europaea, ALLEA, EASAC, Euro-CASE, FEAM, YASAS — that bring together some 120 academies from over 40 countries across Europe. The academies’ fellows have expertise in a diverse range of fields, including natural sciences, engineering, technology, medicine and health, agricultural and social sciences, and humanities. SAPEA follows a comprehensive EDI strategy incorporating experts from all relevant scientific fields of the scientific community, focussing on integrating at least 10% early-career and 30% mid-career researchers, achieving gender balance and ensuring wide geographical representation from across Europe. SAPEA works to raise awareness of the SAM’s activities, and to improve the quality of public debate about the role of evidence in policy, contributing to the transparency of EU policymaking. SAPEA engages with policymakers, the scientific community, stakeholders and the wider public in a range of D&E&C activities, including websites, social media, events, media relations, and a range of publications. More information can be found on the project´s website: www.scientificadvice.eu.

Keywords: scientific advice mechanism,science for policy,european academy networks,group of chief scientific advisors,evidence review reports,systematic literature reviews,gender diversity,policymakers
Validation of a new drug target in non-alcoholic steatohepatitis (NASHTARGET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This research focuses on the increasing prevalence of metabolic liver disease, specifically non-alcoholic steatohepatitis (NASH), which is driven by obesity, diabetes, and its related causal connections. NASH is a significant medical challenge with no approved treatments, causing a substantial economic burden. The project aims to investigate the role of oxidative stress in NASH development and progression. By targeting the MAP kinases p38 and JNK, which drive the inflammatory and fibrotic aspects of NASH, our research could lead to new treatment approaches.
Green dEal cOmpliant iRriGation Increasing Europe’s Agriculture resilience to drought (GEORGIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Greece,Luxembourg,Italy,Serbia,Bulgaria,Cyprus,Poland,Austria,Belgium
Call: Improving irrigation practices and technologies in agriculture (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 5939603.2
EU funding (EUR): 4970932.24
Participants: 17
Project status: SIGNED

GEORGIA (Green dEal cOmpliant iRriGation Increasing Europe’s Agriculture resilience to drought) consortium, consisting of 16 partners from 9 European countries and led by Synelixis SA (the provider of SynField smart agriculture platform), has joined forces to increasing the resilience of agriculture to drought enhancing efficiency in water management. The project assesses drivers and barriers of key innovative irrigation systems, including environmentally responsible recycling of sewage sludge and biowaste streams, biological water-absorbing geocomposites, as well as water abundance and scarcity solutions. In parallel, GEORGIA pursues their optimal application through local condition modeling and employment of Artificial Intelligence. To this end, the partners develop in-situ, drone-based and geospatial monitoring, an eXplainable-AI decision support system as well as Crop Digital Twins. GEORGIA enhances and validates these technologies starting from the farm level and upscaling at large-scale and catchment levels. The socio-techno-economic approach is validated in 7 pilots in 6 countries, connected through a Federated Deep Machine Learning architecture. GEORGIA covers multiple crops, production types (conventional, intensive, agroecology and organic) and geographical regions, namely a) Mediterranean (Greece, Cyprus), b) Southeast Europe-Balkans (Bulgaria, Serbia) c) Central Europe-Midland (Austria), and d) Continental Europe-Baltic Sea (Poland). We will be able to collect and process sensor data from farms that span from the Southern to Northeast Europe, along with organic and non-organic production. We will also have access to large facilities such as Biological Cleaning Plant at BSL 3 covering large private farms, a Greek island (Santorini) and a Greek Region. More than 1,200 farmers will be directly involved in the experimentation phase, providing insights and feedback on AgriDataSpace platform and knowledge provided and more than 89,000 farmers will be dire

Keywords: ai supported irrigation,biowag,nbs,recycled wastewater,crop digital twin,irrigation decision support system
New insights on the circulation and Transport of Upper and interMediate water masses and Biogechemical variability in the north BalEaric CurrenT (TUMBET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

The circulation of upper and intermediate (AW and WIW) water masses play a key role in the hydrodynamics of the Western Mediterranean, where these water masses flow cyclonically along the slope, exhibiting seasonal fluctuations in volume transport. Upon reaching the Balearic sub-basin, the flow splits, with one branch moving south towards the Balearic Channels, while the other forms the north Balearic Current (BC) along the northern slope of the Balearic Islands. Although the Balearic Channels have been recognized as a major pathway for AW and WIW, significant gaps remain in understanding their circulation and volume transports, particularly along the northern Balearic slope and the broader circulation around the Balearic Islands. This project aims to quantitatively characterize the properties and transport of upper and intermediate water masses in the Balearic region, using high-resolution underwater glider data from five areas around the archipelago. The expected results are: 1) a better understanding of the role of the BC in AW and WIW circulation, 2) a detailed characterization of the oceanographic properties of these water masses in seasonal and interannual contexts, and 3) quantify their transport rates in the BC compared to the Balearic Channels and other regions of the archipelago. The host institution expertise in physical oceanography, marine biogeochemistry, and climate change in the Mediterranean Sea will be crucial for the project’s success and the applicant’s training. The planned secondment will focus on using inverse box models to assess water mass transports, leading to a more in-depth knowledge of circulation patterns in the Balearic Islands. This pioneering work will extend European leadership in Mediterranean hydrodynamic studies, address key EU challenges under Horizon Europe and provide valuable insights for numerical modelers. TUMBET represents an extraordinary opportunity for the applicant’s scientific and professional development.

Keywords: oceanography,water mass circulation,hydrography,hydrodynamics,biogeochemical variability,inverse box models,underwater gliders,climate change,mediterranean sea
Systemic Integration of Transformative Technical and Nature-based Solutions to Improve Climate Neutrality of European Cities and Regions and tackle Climate Change: the URBreath Approach (URBREATH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Belgium,Italy,Germany,Greece,Romania,Denmark,Spain,Netherlands,Estonia,Czechia,Finland,Switzerland
Call: Urban greening and re-naturing for urban regeneration, resilience and climate neutrality (HORIZON-MISS-2023-CLIMA-CITIES-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 14963862.5
EU funding (EUR): 13227485.0
Participants: 37
Project status: SIGNED

URBREATH vision is to develop, implement, demonstrate, validate and replicate a comprehensive, community participation and NBS-driven urban revitalisation, resilience and climate neutrality paradigm that will ultimately radically enhance the social interactions, inclusion, equitability and liveability in cities. Specifically, the aim of the URBREATH project is to implement hybrid/Natural Base Solutions putting at the heart of the decision-making process the communities within a city. Advanced techniques, particularly Local Digital Twins and AI, and social innovation will facilitate the achievement of its vision. The project will have four phases: 1. Inception, 2. Development, 3. Piloting, 4. Transition. The preliminary results of a single Phase are evaluated within the following Phase so to allow for feedback before releasing the final version. The Inception phase will define the methodology to be followed for the project development and will deliver the project functional and technical requirements. The second phase will release the URBREATH technical framework, consisting of tools to manage the whole data value chain and to support end-users to collaborate on the design and creation of NBS to be used in the city/district. It will be used to monitor and take decisions on the NBS to be implemented/deployed in the Piloting phase (evidence-based decision making), that involves 4 Front Runner Cities in 4 different climatic zones: Cluj-Napoca (RO - Continental), Leuven (BE – Atlantic), Madrid (ES – Mediterranean), and Tallin (EE – Boreal). During the Transition phase, all the information, results and lessons learnt from the previous steps will be collected and analysed to provide recommendations and foster replication activities and the uptake of project outputs at the end of its lifespan. To this aim, 5 Follower Cities are involved: Aarhus (DK), Athens (EL), Kajaani (FI), Parma (IT), Pilsen (CZ), linked to the Front Runners for climatic zone and/or dimension.

Keywords: systemic transformation,urban living labs,climate change models,modelling and simulation,local digital twins,smart cities,impact assessment and evaluation
Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities (GLP1RES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes mellitus (T2DM). However, a subset of patients does not respond to these agents or develop treatment resistance, which poses a significant clinical challenge. Emerging evidence from our work in humans and mice shows that endogenous amidated hormones synergize with GLP-1RAs to reduce glycated hemoglobin, and their absence promotes GLP-1RA resistance. This proposal explores the intricate mechanisms by which endogenous amidated hormones affect endogenous GLP-1 secretion, modulate its function, and influence the effectiveness of GLP-1RAs. Furthermore, it will investigate which characteristics predict the GLP-1RA effectiveness in patients, and test potential therapeutic approaches to prevent detrimental GLP-1 resistance mechanisms with the goal of ameliorating T2DM treatment and outcomes. A plethora of approaches will be used to elucidate amidated hormone-induced GLP-1 resistance. We will study L-cell functions and GLP-1 endogenous secretion in vitro and in vivo in the absence of amidated hormones. With tissue-specific genetically engineered mice, we will selectively deplete key amidated hormones that counteract the effects of GLP-1RAs and dissect their contribution in physiological readouts of GLP-1RA resistance. Lastly, we will leverage machine learning approaches to clinical data analysis on large deeply phenotyped biomedical cohorts to select for patient characteristics that determine the likelihood of developing GLP-1RA resistance, and to assess the combinatorial contribution of amidated hormones on T2DM susceptibility. By combining experimental and computational approaches, this project aims to gain a deeper understanding of the complex interplay between endogenous hormones (and their combinatorial effects) and GLP-1 signaling, to develop more effective and personalized therapies, and ultimately to improve clinical outcomes in individuals with T2DM.

Keywords: glp 1 receptor agonists,type 2 diabetes mellitus,amidated hormones,glp1 ra
Migration, Diaspora, Citizenship (MDC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,United States,India,New Zealand,Australia,Brazil,Japan,Poland,Italy,Colombia,United Kingdom,Burundi
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1050720.0
EU funding (EUR): 1050720.0
Participants: 18
Project status: SIGNED

The COFUND Fellowship Programme “Migration, Diaspora, Citizenship” is part of the strategy of the University of Muenster (WWU) to further internationalise postdoctoral research and training in the social sciences and humanities and to strengthen their interdisciplinary and intersectoral dimensions. In the context of the proposed MDC Project, the WWU pursues four primary aims: first, to enhance the academic and non-academic career prospects of the fellows participating in this programme; second, to build a cadre of researcher-practitioners who are able to communicate, work and cooperate across national, sectoral and disciplinary boundaries; third, to share best practices within a large and growing international network of academic and non-academic partner organisations. Last but not least, the fourth, long-term aim of this project is to effect sustainable change in academic structures and human resource development by contributing to the creation of a new academic culture that fully supports and rewards interdisciplinary and intersectoral research. With its focus on the social sciences and humanities, this programme targets fields where interdisciplinary and intersectoral training and research are still relatively uncommon and underdeveloped, particularly in comparison to the natural and life sciences. In tackling these deficits, the WWU will rely on existing training programmes, academic networks and its long-term experience with high-profile research projects in the respective fields. By centring the programme around the ubiquitous and interconnected phenomena of migration, diaspora and citizenship, the MDC Project builds upon established research excellence among its partners and opens up research opportunities for scholars with a wide range of academic interests and backgrounds while also facilitating high-quality interdisciplinary and intersectoral collaboration among the fellows and partner organisations, which is key to accomplishing the above-mentioned aims.

Keywords: migration diaspora citizenship social sciences and humanities globalisation transnationalism transformation of societies social cohesion global governance human and civil rights