Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PROPEL ENERGY EFFICIENCY FINANCE (PROPEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Belgium,Netherlands,Luxembourg
Call: Financing for energy efficiency investments - Smart Finance for Smart Buildings (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2023-11-30
Duration (months): 30.0
Total project cost (EUR): 1495317.5
EU funding (EUR): 1495317.5
Participants: 5
Project status: SIGNED

The potential for mainstreaming energy efficiency financing will be addressed by the PROPEL consortium by creating a single, holistic resource centre in Europe, which will be maintained and has ALL the critical collateral and resources required to develop, sell, contract and finance sustainable energy projects at the required scale. The PROPEL project will build on the consortium’s significant ownership of, and access to, the full range of necessary standardised financing collateral, to deploy this collateral in the market while at the same time, firmly establish an industry association, the Sustainable Energy Finance Association (SEFA), which will act as THE knowledge and resource centre for the mainstreaming of finance into sustainable energy assets, not only during the project’s lifetime but long after its completion. The PROPEL project will develop an integrated ecosystem of financing collateral and relevant actors, which together will drive the market for sustainable energy assets forward. PROPEL will focus on building and testing this ecosystem in four countries (Belgium, Greece, Italy, Netherlands), reaching out to a minimum of 400 EE projects developers (supply side), 50 end-client representatives (demand side), and 30 financiers (banks and financial funds). PROPEL is expected to trigger €20M of investments into EE Projects within the project duration, leading to 40,46 GWh of annual primary energy savings and 10’890 tCO2 savings. These impacts are estimated to grow 25 fold within the 5 years after the project, due to PROPEL’s aim at creating a long-lasting eco-system, which will be hosted by SEFA. The PROPEL consortium has a wealth of expertise in developing standardised collateral and putting together the building blocks for development of a single ecosystem of collateral and actors that will enable and facilitate the scaling up and acceleration of financing to the sustainable energy market.

Keywords: energy efficiency,financing,securitisation,education,knowledge centre,standardisation
Organic-Inorganic perovskite and organic semiconductor films with improved crystal properties via reel-to-reel solution coating; application to photovoltaics and field effect transistors (Crystal Solar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

This project will develop low cost and scalable solution–based coating techniques to yield electrically tunable films with macroscopic crystalline domains of both organic–inorganic perovskite and organic semiconductors. These layers will be used to prepare solution processed hybrid perovskite-based photovoltaic (PV) devices surpassing 20 % solar-to-electricity power conversion efficiency, to provide a low cost and renewable energy supply. The researcher will carry out the processing and characterization of the materials at Professor Zhenan Bao's laboratory at Stanford University. Professor Bao is a world leader in using solution deposition techniques to tune the physical and electronic properties of solution-processed semiconductors for use in FETs, and is well suited to extend this approach to perovskite PV. The skills and knowledge obtained at Stanford University will be brought back to Professor Henry Snaith's laboratory at Oxford University and to Oxford Photovoltaics ltd to prepare low cost, scalable perovskite PV with enhanced macroscopic crystal properties and performance. Professor Snaith is recognized as one of the pioneers in perovskite based PV, and is thus excellently placed to guide the researcher in the development of PV with superior performance for eventual employment as large-scale energy supply. This project will form a unique union of two world leading research groups with complementary expertise. There is great potential for the transfer of skills, generation of intellectual property, and industrial involvement within the EU via the ISIS program at Oxford University, and the company Oxford Photovoltaics of which Professor Snaith is the CTO.

Keywords: photovoltaics,solution processed semiconductors,organic inorganic perovskites,crystal formation
Treatment of EGFR over-expressing cancers by targeted non-viral delivery of PolyIC (Cancer-Targeted PolyIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We have recently shown that application of EGFR targeted synthetic dsRNA: Poly Iosine/Poly Cytosine (pIC) is highly efficient and selective against deadly cancers overexpressing EGFR, like glioblastoma (U87MGwtEGFR), breast cancer (MDA-MB-468) and adenocarcinoma (A431). Double-stranded RNA, frequently expressed in cells infected with viruses, activates a number of pro-apoptotic processes simultaneously. These dsRNA-induced mechanisms efficiently kill infected cells and induce expression of anti-proliferative cytokines from the interferon (IFN) family, thereby preventing spread of the virus. pIC delivered with Melittin-polyethylenimine-polyethyleneglycol-EGF (MPPE) eliminated orthotropic and subcutaneous tumors of the above cancers. Heterogeneous glioblastoma models where only half of the cells overexpress wtEGFR are also eliminated by local application, most likely due to a bystander antiproliferative effects, at least partially mediated by interferons (Shir et al., 2006). Systemic application of EGFR targeted pIC is also highly effective against breast and adenocarcinoma disseminated cancer models resembling metastatic cancers (Shir et al., 2011). During the last two years we have improved the vectors homing to EGFR to entities that can now be translated into clinical agents (Shaffert, 2011; Shir 2011, Abourbeh 2012). The impressive results with these more simplified vectors, make this project ready for clinical development, which requires fund raising from a Company/Venture capitalist. Commercialization of the therapy will be detailed in the proposal.

Keywords: cancer,dsrna,egfr,cancer therapy,immune system
FINDER: FIghtiNg DEngue viRus, a novel strategy for the development of fully protective antivirals that act by disrupting the DENV NS3/NS5 interaction (FINDER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Dengue virus (DENV) is the most prevalent arthropod-borne viral pathogen and infects about 400 million people worldwide every year, causing epidemics that are spreading rapidly, with increased frequency and magnitude. To date, no specific treatments or a fully protective vaccine are available for dengue. In line with the Priority 3 of H2020, the development of effective therapeutic strategies against DENV is urgently needed. The purpose of FINDER is that of developing innovative anti-dengue candidate drugs able to disrupt the protein-protein interactions between the viral NS3 and NS5 proteins, two key and conserved enzymes of DENV replication complex. To this end, some druggable cavities at the NS3/NS5 interface will be identified and an in silico screening of a virtual small molecule library will be performed to search for potential inhibitors of NS3/NS5 interaction. After the selection and the biological characterization of the hits, a hit-to-lead optimization step will be carried out to find compounds with lead-like properties. Such drugs are expected to be endowed with broad-spectrum antiviral activity, a reduced risk for developing resistance and lower undesirable side-effects. Through a comprehensive dissemination and exploitation strategy, one or more drug candidates will be evaluated in the future in animal models and then in clinical trials. The outcomes of this project could fill the gap of the lack of effective anti-DENV drugs, resulting in an enormous impact on world-wide public health, as well as on the European competitiveness in this area. This project will also contribute to strengthen a wide set of skills of the applicant by a multidisciplinary training in the field of antiviral research, which will make him ready for attaining a position of independent researcher. In addition, the complementary competencies between the applicant and the supervisor will allow a two-way transfer of knowledge, leading to a benefit also for the Host Organisation.

Keywords: dengue,dengue virus,antiviral strategy,anti dengue inhibitors,protein protein interactions,ns3 ns5 interaction interface,in silico screening,hit to lead optimization,dengue polymerase assembly
Dynamic aircraft MAterial property Database (DeMAnD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Portugal
Call: Database of dynamic material properties for selected materials commonly used in aircraft industry. (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-09-01
End date: 2018-03-31
Duration (months): 19.0
Total project cost (EUR): 299901.25
EU funding (EUR): 299901.25
Participants: 3
Project status: CLOSED

The DeMAnD project has been set up to plan and execute an efficient mechanical material characterization program to deliver within the time duration set out by the JU a dynamic material property data base for typical aircraft materials, with a special focus on seat and crash absorbing structures of small aircraft. This dynamic material characterization will be carried out over a wide range of strain rates, ranging from quasi-static loading up to high strain rates of 500 s-1. The project brings together renowned experts in the areas of test method development, static and dynamic testing of aircraft materials and structures, simulation and design of aeronautical crashworthiness structures and data reduction and preparation for dynamic finite element codes and material models. For the various strain rate regimes, the best suitable test equipment has been identified and is available within the consortium. This will ensure the determination of high quality material data and complete stress-strain curves from static up to high strain rate loading, allowing the derivation of the strain rate dependent material behavior for all material properties needed for predictive crashworthiness simulations.

Keywords: dynamic material properties,high strain rate,crash,aircraft seat
DEterministic MOlecular N-photon Source (DEMONS) (DEMONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Single-photon sources are quantum light sources that, when triggered, emit deterministically a single photon and are therefore highly desired in many applications such as quantum imaging, sensing and in information processing. Hence, single photon sources have been an ongoing subject to research for many decades and nowadays even a few start-up companies offer single photon sources. However, for many applications on-demand single photon emission is not sufficient, but deterministic N-photon sources are required that emit exactly N photons with N≥2. These novel N-photon sources do not exist yet but have a broad range of applications, including applications in quantum metrology and lithography, the production of NOON-states for quantum information processing, superresolution microscopy and even medical imaging applications. In the action “DEMONS” we will realize a high-fidelity N-photon quantum light source at the Max Planck Institute for the Science of Light (MPL). More precisely, we will utilize light–matter interactions between molecules and an open scannable and tuneable microcavity at cryogenic temperature to create exotic quantum states that will emit multiphoton quantum light. To do so, we will start with the Fabry-Pérot open microcavity developed at MPL and improve its design for the purpose of this action. Afterwards, we will examine two complementary approaches to create a N-photon quantum light source: In the first approach we will use cooperative coupling of N emitters via the common light field of the microcavity, whereas in the second approach, we will exploit the nonlinearity of the strongly coupled single molecule-microcavity system and create a photon blockade to generate deterministic emission of N-photon bundles. The successful outcome of this action will be the first experimental realization of a high-fidelity N-photon emitter and is expected to boost research in various interdisciplinary areas from bio-imaging to photonic quantum simulation.

Keywords: quantum emitters,molecules,spectroscopy,microcavity,strong coupling
Ecological extinction and evolution: answers from ancient biomolecules (Evolution)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Previous studies on extinct Pleistocene megafauna attempted to decipher species’ responses to environmental change through genetic studies and palaeodietary reconstruction. However, none of these studies addressed the issue whether changes in palaeoecology represent evolutionary processes or are instead a result of environmentally induced plasticity. The present research project proposes novel ways of addressing the aforementioned question through an interdisciplinary approach including palaeogenomics, ancient epigenomics and palaeoecology. The project will focus on a case study of cave bear populations in the Romanian Carpathians, a key region of their distribution prior extinction showing the most dramatic dietary differentiation among cave bears across their entire geographical range. We will explore the response of Late Pleistocene cave bear populations to environmental heterogeneity, and determine the genetic and epigenetic processes that led to these differences in Romanian cave bears. To achieve this, we will carry out next-generation sequencing of cave bears from different time-related populations with various dietary patterns. This dataset will constitute the most complete cave bear genome dataset ever analysed, allowing us to gain an unprecedented understanding of cave bear evolutionary history and moving forward the field of evolutionary epigenomics. This project will provide new research avenues that the experienced researcher will be able to exploit in order to reach and reinforce a position of professional maturity and independence. The experienced researcher will also be trained in cutting edge scientific techniques and analyses, as well as a number of skills that are transferable between countries and sectors (including management, grant writing, communication and teaching), and that will facilitate her development into a research leader.

Keywords: ancient dna,population genomics,epigenomics,palaeoecology,evolutionary biology,cave bears
ZEbrafish Neuroscience Interdisciplinary Training Hub (ZENITH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Germany,Spain,Germany,Germany,France,France,France,United States,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 4096014.48
EU funding (EUR): 4096014.48
Participants: 22
Project status: SIGNED

A fundamental challenge for Neuroscience is to understand how neural circuits process information from the outside world and internal physiological states, to produce versatile but reliable behavior. Two major research challenges are: 1) the complexity and distributed nature of neural circuits; 2) the need for data spanning multiple scales from molecular and activity phenotypes of single cells through to circuit connectivity and population dynamics and finally the behavioral output itself. The goal of the ZENITH ETN, “ZEbrafish Neuroscience Interdisciplinary Training Hub”, is to understand how neural networks mediate perception and behavior. We will exploit the advantages of zebrafish as a small transparent vertebrate with superb genetic accessibility and use cutting-edge technology to elucidate the interactions between molecules, cells and entire networks that ultimately generate adaptive behavior. Our training goal is to create collaborative, interdisciplinary young scientists who can tackle major challenges within neuroscience research. Training in cutting-edge technologies and analytical frameworks will enable this next generation of researchers to perform integrated, multi-scale analyses to elucidate the neural basis of naturalistic behavior. Training is centered on highly collaborative projects between physicists, mathematicians and biologists that will expose ESRs to broad training with academic and industrial partners. Advanced optical methods and genome-editing will be utilized to link molecules to circuits, to map connectivity between cell types across the nervous system and to build computational models of brain activity that will be experimentally tested. Overall ZENITH will help to change the way young scientists are trained in Europe and provide the conceptual, technical and analytical skills needed to take on the challenge of understanding how the beautifully complex circuits of the vertebrate brain control behavior.

Keywords: neural circuits,sensory motor integration,naturalistic behavior,zebrafish,data driven models
Training the next generation of leaders to deliver innovations in dignified sustainable care systems for older people (INNOVATEDIGNITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Greece,Greece,Sweden,Sweden,Greece,Denmark,Denmark,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 4325097.6
EU funding (EUR): 4325097.6
Participants: 19
Project status: SIGNED

INNOVATEDIGNITY is a trans-national network that aims to deliver a shared, world-leading research and training programme to educate the next generation of thought leaders with the necessary research experience and transferable skills to deliver innovations in dignified, sustainable care systems for older people, including new care models and digital applications. INNOVATEDIGNITY’s research examines older peoples' perspectives of care systems with a specific focus on dignity, investigates the potential for digital applications, and analyses gender issues to provide crucial, urgently needed knowledge for sustainable and fit for purpose care that supports older people to live well. The network's programme of investigation: 1) Critically evaluates existing care systems and provide analyses that make use of older persons’ insights. 2) Examines and offers a range of conceptual, empirical and methodological conditions to develop new innovations, including digital technology that offer dignity in care. 3) Provides an analysis of impacts of new care models on the wellbeing of older people. 4) Critically examines impacts of gender on care delivery, on the leadership of caring and science careers, and the care workforce with insights for sustainability. INNOVATEDIGNITY addresses the European problem of how ageing people can live well in caring systems with a concentration on cross-disciplinary scholarship, producing an evidence base through fifteen PhD projects, interlinked with a series of integrated assignments, and supported by a coherent interdisciplinary training. INNOVATEDIGNITY will produce leaders well versed in innovating care from standpoints within and beyond ‘healthcare’, sectors that engage technology, the public, policy makers for the benefit of older people in Europe beyond the consortium nations.

Keywords: dignity in care,caring science,elders perspectives of technology,care system,sustainability and workforce competence,gender,engagement with older people about fit for purpose care models