Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering synthetic mechanotransduction through nucleocytoplasmic transport (MechanoSynth)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

Our understanding of cell biology has reached the point in which cells can be exogenously engineered to carry out specific tasks. This is typically applied to generate gene circuits that respond to biochemical interactions between specific molecules. However, cells sense not only biochemical but also mechanical signals, in the process of mechanotransduction. Here, we propose to re-engineer cell mechanotransduction from scratch, in a manner that is not based on any endogenous cell signalling pathway. We will achieve this by harnessing our novel findings that force application to the cell nucleus regulates transport through nuclear pore complexes (NPCs), in such a way that proteins can be made to translocate to the cell nucleus with force by appropriately tuning their active and passive transport properties. First, we will implement a mechanosensing element, involving a precise understanding of the mechanical parameters regulating nucleocytoplasmic transport, and subsequent design of molecules with optimal mechanosensitivity (that is, force-dependent nuclear localization). Second, we will implement a control element, enabling a system to control to what extent, and for how long, force reaches the nucleus and triggers subsequent mechanosensing. Finally, we will implement a functional element, by which mechanosensitive molecules will be engineered to trigger the transcription of specific genes in the nucleus. As a proof-of-concept, we will apply this system to re-engineer three main properties of fibroblasts and mesenchymal cells (matrix remodelling, migration, and epithelial/mesenchymal plasticity), all involved in pathological responses to altered tissue mechanics. This project will deliver synthetic mechanotransduction, a novel tool that will be orthogonal and compatible with existing cell engineering approaches. Further, it will provide an answer to the fundamental question of how a functional, biological mechanotransduction system can be generated de novo.

Keywords: nuclear mechanics,nuclear pore complexes,fibroblasts
CYPRUS 2026 EU CONFERENCE: ADVANCEMENT OF TREATMENTS FOR RARE DISEASES (CY26-RARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Coordination and support actions
Countries involved: Cyprus
Call: Presidency event - Cyprus. Advancement of Treatments for Rare Diseases (HORIZON-HLTH-2025-06-IBA, 2025)
Start date: 2025-11-01
End date: 2026-04-30
Duration (months): 6.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 1
Project status: SIGNED

Rare Diseases (RDs), often called orphan diseases, are a diverse group of disorders that collectively affect a significant number, approximately 30 million people in EU. The majority of rare diseases have a genetic origin and encompass a wide range of pathological conditions, many of which are chronic, debilitating and may shorten lifespan. Due to the rarity, complexity and the limited available knowledge, rare diseases pose significant challenges in terms of diagnosis, treatment and access to specialised care. Efforts to address rare diseases involve multidisciplinary collaboration, innovative research and policy initiatives aimed at improving outcomes for affected individuals. Moreover, the socioeconomic impact of rare diseases at the individual, health care and societal levels is significant, but in countries with centralised healthcare systems, the cost is spread out given the rarity of theses diseases. The proposed high-level conference on the advancement of treatments for rare diseases (RD) within the EU, will be organised under during the Cyprus Presidency of the Council of the European Union, as one of the of the Presidency events. The conference aims to strengthen collaboration, foster innovation, and drive development in the field of rare diseases management. The conference will highlight the goal of making Europe “the global beacon for life sciences by 2030”, support concrete health benefits to rare diseases patients, through better prevention, diagnosis and treatment. This two-day event will focus on promoting excellence, innovation, collaboration and synergies on treatments for rare diseases.

Keywords: rare diseases,advancement of treatements,eu conference,cy presidency event
Quantum Grenoble Doctoral Programme (QUANG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,Finland,Germany,Netherlands,Switzerland,Spain,Singapore,Japan,Sweden,Greece,Italy
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2028-06-30
Duration (months): 66.0
Total project cost (EUR): 3628800.0
EU funding (EUR): 3628800.0
Participants: 30
Project status: SIGNED

The application of quantum phenomena to the development of new technological applications is one of the challenges of this century, as it promises to revolution citizens’ lives on communication, sensing, computation, and security. Quantum technologies are a priority of European and national stakeholders, in order to secure European technological sovereignty in this highly strategic field. As renowned actor in quantum science and technology, Université Grenoble-Alpes is proposing a COFUND DP aimed at efficiently train research fellows in this emergent domain, facing short to long-term challenges, and to build their career perspectives with various track options (short to medium-term positions, in private employment market, where the need of several thousand jobs profiles in quantum topics is expected to emerge in the next eight years, and in renown research centres all across Europe). Fellows will be at the forefront of emergent quantum discoveries from fundamental science to novel technologies, in a “3i” ecosystem, with perspective to diversify their set of skills and forge new mind sets and approaches to research and innovation. QuanG will rely on the strong basis sets by previous COFUND, enabling fellows to be rapidly recruited using robust, efficient, fair and transparent recruitment and integration process, and immersed in excellent training and supervision conditions, both from research and transferable skills perspectives. Besides, QuanG will aim at including all types of minorities and will strongly encourage women applications. 30 Associated Partners, academics and industrials, and 17 laboratories are supporting UGA in pushing forward this ambitious project, that will recruit 36 PhD fellows, over 4 calls, for a duration of 5 years. UGA consortium will invest 60% of the total funding available to fellows noticeably covering research, training, communication and selection costs.

Keywords: quantum technologies,quantum science
eB2 MindCare: An AI Platform for Mental Health (eB2 MindCare)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

eB2 MindCare is a CE-marked digital-health platform that transforms behavioral data from smartphones and wearables into clinically validated insights for mental-health monitoring, prediction, and prevention. Developed in collaboration with leading hospitals and research institutions, it enables continuous, AI-driven assessment of patients’ functioning, mood, and relapse risk—empowering clinicians to deliver proactive, personalized care. Mental disorders affect one in six Europeans and cost over €600 billion annually. Most begin early, become chronic, and remain underdiagnosed or poorly monitored due to fragmented care and lack of objective tools. eB2 MindCare addresses this gap by combining passive behavioral data with explainable AI algorithms that detect early signs of deterioration and support clinical decisions. In ongoing studies, the system achieves a 50 % reduction in suicide attempts, demonstrating its transformative potential. The platform integrates seamlessly with EHR, HIS, and CRF systems through APIs and SDKs, ensuring interoperability and data security. It is already used as a routine clinical service at ITA Salud Mental and San Juan de Dios, supporting more than 7,500 patients and 500 clinicians. eB2 operates a scalable SaaS model, generating revenue and growing >40 % annually. By 2027, it aims to reach 50,000 patients, 3,000 clinicians, and €4 million ARR, expanding into Germany, France, Italy, the UK, and the Nordics. The EIC grant will fund the evolution to TRL 8, including CE Class IIa certification and a new Agentic AI framework based on LLMs for context-aware reasoning and clinical decision support. With strong clinical validation, proprietary data assets, and freedom to operate, eB2 MindCare is set to become Europe’s reference platform for trustworthy, explainable, and proactive AI in mental health.

Keywords: ai driven mental health,behavioral biomarkers,real time monitoring,suicide prevention,personalized interventions,digital therapeutics
Negotiating Digital Technologies in Palliative Home Care (NEDIPAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Most Europeans wish to spend their final hours at home, surrounded by loved ones. Specialist palliative home care services have been established to fulfill this wish, even for patients facing severe terminal illnesses. The sociological research project NEDIPAL: Negotiating Digital Technologies in Palliative Home Care aims to better understand the intricacies and challenges of using digital technologies – such as teleconsultations, apps, wearables, and artificial intelligence – to make palliative home care more accessible to a broader range of patient groups, while also enhancing its economic and environmental sustainability. Current research typically views digital technology usage in palliative home care either from the viewpoint of patients and family caregivers or of professionals, with both seeming decoupled from one another. In contrast, NEDIPAL examines the co-production of palliative home care by professionals in collaboration with patients and family caregivers, through the lens of systems and organizational theory. The sociological project transcends disciplinary boundaries by integrating insights from health services research, palliative medicine, communication, and digital inclusion. The research will involve qualitative on-site field studies in the Belgian region of Wallonia at five interdisciplinary “Équipes de soutien à domicile”. NEDIPAL is hosted by BRISPO, an interdisciplinary research center specializing in digitalization, health, life course, and aging. With my supervisor’s international experience and unique competence, along with my prior research in palliative home care and experience in France, I am confident that I will achieve NEDIPAL’s research and training objectives and position myself as a leader in research on the digitalization of palliative care. This project will prepare me for achieving my mid-term career goal of working in Belgium or France and help me advance my non-academic career as an expert in digital health services.

Keywords: systems theory,organizational sociology,qualitative research,care work,digitalization,sociology of health and medicine,palliative care
Creation of innovative functional textile fibers through valorization and utilization of wastewater streams from silk fiber production (SESI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Bulgaria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Textile industry is one of the most polluting industries in the world. It depends mostly on non-renewable resources and annually uses around 100 billion cubic meters of fresh water. The SESI project's main goal is to utilize and valorize the wastewater streams in the silk fiber industrial production, applying a circular economy business model. The resulting innovative natural material is the latest generation of functional fibres, manufactured with components from the recycled wastewater streams and has high-performance properties that are valuable for various industries like medicine, aerospace, fashion, cosmetics, and food. Supply chain difficulties result in a real loss of value for the textile industry. Raw materials and primary products are scarce and expensive. There are a number of companies developing innovative organic raw materials for the textile industry but none have yet reached the industrial scale and volume of production needed by textile manufacturers. SESI functional fiber is a disruptive innovative solution that could enter the EU market and help to decrease this deficit. This revolutionary transformation will supply the textile industry with low-emissions silk fibers minimizing the environmental footprint, and will aid the textile and fashion industry in the EU to transform easier from "fast fashion" towards "low fashion" trend. This innovative fiber will make a significant contribution for creating textiles that last longer, are repairable and recyclable, and that are non-synthetic and non-toxic for the environment. The innovative SESI silk fibre will contribute to reducing the dependence of European enterprises on imports from third countries and will guarantee their access to a valuable raw material at much more competitive price levels compared to the imported ones.

Keywords: novel textile materials,resource recovery,wastewater treatment,sustainable fashion,circular economy,environmental protection,mitigation of water scarcity challenges,green technologies
TRANSFORMING MICROALGAE CULTIVATION TO BOOST AQUACULTURE (INALVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Inalve develops a revolutionary technology for microalgae production and addresses first the aquaculture market. Aquaculture is central to providing food security to a future 10B inhabitants without depleting the planet’s resources. This capacity is currently hampered by the low performance of a key link in its value chain: hatcheries. These are composed of ponds where zooplankton used as live-feed are produced and the larvae of fish, crustaceans and shellfish are raised. In the ocean, microalgae play a vital role for animals as base of aquatic food chain. However, with existing technologies, hatcheries fail to source live microalgae. Hatcheries either use substitutes, with poor performance, or end up cultivating microalgae on site, which is a heavy burden and greatly reduces their efficiency. Inalve has developed a unique cultivation technology allowing the commercialisation of highly-concentrated live microalgae. The high concentration, essential for logistics and transport, is naturally obtained without requiring any dewatering processes which would spoil the fragile algae. Early customers have shown great satisfaction testing the product, in terms of ease of use and of the performance gains it allowed (greater health and vitality of the larvae and juveniles, major yield gains). The goal of this EIC Accelerator application is to finalize the R&D to bring the technology from its current pilot scale (with early customers) to a full-scale demonstrator of a production facility and then towards opening several farms in Europe. Within the EIC Accelerator's "food from precision fermentation and algae" challenge, the expected impact of Inalve's project is to greatly improve the performance (productivity, sustainability, profitability) of aquaculture hatcheries, which will in turn benefit the whole value chain and boost aquaculture. This will improve European food supply chain independency, efficiency, resilience, and help attain healthy and sustainable food for all.

Keywords: live concentrated microalgae,aquaculture hatcheries performance,sustainable food,innovative production process
Partisan care: women’s wartime experiences in the Yugoslav Partisan Medical Corps (YUCARE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovenia
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 182717.52
EU funding (EUR): 182717.52
Participants: 1
Project status: SIGNED

The onset of World War II saw an unprecedented number of Yugoslav women join the Partisan forces in the National Liberation Struggle (NOB). In order to build support amongst conservative rural populations, Partisan forces relied on the appropriation of traditional gendered structures, leading to the creation of a complex medical infrastructure heavily reliant on the participation of women. Whereas contemporary scholarship has primarily focused on the histories of women combatants or of women’s political organization, little attention has been paid to the largest demographic of Partisan women: the doctors, nurses, pharmacists and auxiliary staff tasked with caring for the sick and wounded. The MSCA project YUCARE traces the biographies of five notable women medical workers, using their wartime trajectories as a starting point for discussing the diversity of experiences encompassed within the sanitet. The project addresses two central questions: focusing on the overlooked experiences of women in the Yugoslav Partisan Medical Corps, it explores the divergences between accepted narratives and individual experiences to integrate temporal, geographic and demographic differences into a broader gendered history of World War II. Secondly, it explores how traditional gendered structures were maintained, challenged and negotiated within the Partisan army, and how these contributed to the state-building practices of the fledgling socialist state. This empirical objective is compounded by the combination of a microhistorical methodology with digital history tools, building on actor memoirs and a unique collection of archival materials to evaluate and communicate results in a web-based map format. By acquiring new skills in database management and virtual mapping, YUCARE will enable me to reach my desired specialization in digital historical communication while grounding myself professionally in my region of study.

Keywords: world war ii,yugoslavia,national liberation struggle nob,women partisans,social history of war,military medicine,care labor,microhistory
Holonomy, symmetry and geometric flows (HOLYFLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The geometric objects that can be perceived by our senses are curves and surfaces. Submanifolds provide a natural generalization for higher dimensions of these objects. The focus of this project is on totally geodesic submanifolds and isoparametric hypersurfaces, intriguing classes of submanifolds with connections to various mathematical areas, often studied using differential geometric, algebraic, or topological methods. The aim of this project is to investigate the interplay of totally geodesic submanifolds with Riemannian holonomy and isoparametric hypersurfaces with certain geometric flows, with the ultimate goal of obtaining results of both intrinsic and extrinsic nature. Specifically, we intend to complete the classifications of totally geodesic submanifolds in symmetric spaces and of homogeneous hypersurfaces in exceptional symmetric spaces. We will also use certain classes of isoparametric hypersurfaces in combination with maximum principles to try to prove an Alexandrov-type theorem in the complex hyperbolic space and long-time existence for the hypersymplectic flow. To develop this project, the Experienced Researcher will join the Geometric Analysis team at ULB in Brussels, under the supervision of one of its main researchers, Joel Fine. The host group has extensive experience in the study of manifolds with special holonomy and geometric flows, using techniques from PDE theory. The training strategy of this project involves assimilating these techniques. Moreover, the ER has experience in the classical theory of submanifolds in symmetric spaces, as evidenced by his contributions to the field. The combination of both backgrounds is essential for developing this proposal. Finally, this MSCA fellowship will enhance the convergence of distinct research fields and collaborative networks, generate synergy with the research performed by the Supervisor, diversify the fellow’s mathematical knowledge, and establish him as an independent researcher.

Keywords: isoparametric hypersurfaces,totally geodesic,homogeneous spaces,symmetric spaces,cohomogeneity one,holonomy,hypersymplectic,geometric flows,constant mean curvature