Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genome-wide surveys and functional analysis of pancreatic cancer metastasis drivers (PACA-MET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1995875.0
EU funding (EUR): 1995875.0
Participants: 1
Project status: SIGNED

Metastasis is the major cause of death in pancreatic ductal adenocarcinoma (PDAC). International sequencing efforts on >800 human primaries gave comprehensive insights into PDAC genetics. In contrast, equivalent studies for “metastasis genetics” were not possible, largely because of a lack of metastatic tissue resources, particularly of treatment-naive ones. Another bottleneck is the scarcity of adequate experimental models recapitulating the multi-step nature of metastasis. As a consequence, the molecular basis of metastasis remains poorly understood. We developed unique resources and tools for metastasis research and propose to use them at three levels to systematically interrogate the molecular underpinnings of PDAC metastasis. We will first perform complementary genome-scale surveys for genes and pathways driving metastasis and metastatic organotropism. We will (i) sequence our unique, largely unpublished resource of 1200 metastatic mouse PDAC, (ii) will perform genome-wide in vivo metastasis screens using transposon tools and approaches, which we pioneered in mice, and (iii) will perturb the human metastasis transcriptome and epigenome. Second, we will validate newly discovered genes using human PDAC cohorts, and through functional studies in mice. We will deploy next-generation metastasis models based on advanced somatic genome engineering. They allow rapid functional studies at an organismal level, thus capturing the complexity of the metastatic cascade. Third, building on our recent discovery of two prototype PDAC metastasis drivers, we will perform in depth mechanistic studies to identify underlying molecular networks and vulnerabilities. This work will unravel - for the first time - comprehensive genetic and functional landscapes of PDAC metastasis. PACA-MET thus promises to uncover fundamental novel biological principles and identify therapeutic targets for one of biggest challenges in medicine.
Noise and vibration in eco-efficient powertrains (ECO DRIVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Italy,Germany,Belgium,France,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-05-31
Duration (months): 51.0
Total project cost (EUR): 3405852.72
EU funding (EUR): 3405852.7199999997
Participants: 9
Project status: SIGNED

With increasing regulatory pressures to reduce emissions, road transport has to play its part. Over the next 30 years, as we shift towards EVs, downsized IC engines and hybrids with eco-powertrains will be central to the automotive sector. ECO DRIVE will develop new technologies for the testing and simulation of eco-powertrains, addressing the complex challenges related to combustion noise, the irritating sound from electric motors, transmission-induced NVH (Noise, Vibration and Harshness) and driveline torsional vibrations, leading to new designs with improved eco-efficiency and NVH performance. The project offers a multi-disciplinary research-training program to the ESRs, with the ultimate aim being to create a new generation of NVH professionals for the transport sector. The technical-scientific challenges are tough: to investigate highly innovative simulation, testing and signal-processing methods for advanced NVH analysis and the engineering of downsized IC engines, e-motors, and novel lightweight transmission systems, to validate and demonstrate the applicability of the developed approaches in an industry context, on both powertrain tests rigs and new vehicles. ECO DRIVE has 9 Beneficiaries from leading academic institutions, top research centres and Europe’s premier vehicle producers. Together, they address the triple-I dimension of research training, being International, Interdisciplinary and Intersectoral. The ESRs profit from top scientific research guidance in combination with highly relevant industrial supervision through the secondment exchanges between the research organizations and the industry partners. The training programme is designed to cover not only eco-powertrains, but also critical transferable skills. The participating organisations gain from their involvement with top-level research; the ESRs receive outstanding Europe-wide training; and society benefits from a new group of young engineers trained in this exciting cross-disciplinary field.

Keywords: eco powertrains,road transport,pollution,electrified vehicles,green transport,green mobility
Electrobioanalytical Applications of Polyoxometalates ([e-POM-Bioanal])

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 2
Project status: CLOSED

The proposed work will exploit the expertise and know-how of the host institute and the fellow to develop a strategy for the detection and screening of genetic mutations in a highly parallelised fashion.The project has an overall objective to develop an electrochemical single nucleotide polymorphism (SNP) detection strategy by using polyoxometalate (POM) labeled DNA (including PCR primers, dNTPs and ddNTPs) for use in solid-phase melting curve analysis and sold-phase array based primer extension and solid phase ligase mediated detection. In order to achieve this, robust surface for anchoring of DNA probes capable of withstanding elevated temperature for enzymatic reactions either in solid phase melting curve analysis or single dideoxynucleotide incorporation will be developed. The proposed strategies will allow for highly cost-effective, rapid and user-friendly platforms for the screening of genetic mutations and single nucleotide polymorphisms.

Keywords: polyoxometalates,mutation,snps,dntps,redox labels,primer extension,surface chemistry,melting curve analysis,genotyping,electrochemistry
Intergenerational Reproduction and Solidarity in an Era of Family Complexity (FamilyComplexity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands,Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-08-31
Duration (months): 70.0
Total project cost (EUR): 2499533.0
EU funding (EUR): 204124.46
Participants: 3
Project status: CLOSED

One of the important consequences of the Second Demographic Transition has been the increasing complexity of families. The aim of this project is to study how rising family complexity has affected two fundamental aspects of intergenerational relationships: reproduction and solidarity. Theoretically, family complexity is distinguished into four dimensions: (a) the length, timing and nature of exposure to the child, (c) biological relatedness to the child, and (c) characteristics of parent-parent ties (triadic effects), (d) characteristics of the wider family network. Using insights from several disciplines, I develop a common theoretical framework for understanding intergenerational reproduction and solidarity. To test the theory, an innovative multiactor survey is developed with an oversampling strategy in which for each adult child, information is collected on all parent figures, and for each parent, information on all adult children. In addition, register data are used to analyze one aspect of reproduction in a dynamic fashion (educational reproduction) and vignette data are used to analyze one aspect of solidarity in more depth (norms prescribing solidarity). By studying reproduction and solidarity as outcomes, I shift the traditional focus from examining how the SDT has affected individual well-being, to the question of how the SDT has affected relationships. In doing so, I analyze a new problem in demography and sociology and contribute to classic debates about population ageing and social inequality. Theoretically, the study of family complexity yields unique opportunities to test ideas about the nature of intergenerational relationships and will shed new light on the traditional dichotomy of social vis-à-vis biological bases of intergenerational relationships. Methodological innovation is made by developing solutions for well-known problems of multiactor data, thereby strengthening the theoretical relevance of survey data for the social sciences.

Keywords: intergenerational solidarity,social stratification,educational inequality,divorce,intergenerational relationships,life course,multipartner fertility
Co-creating change: experimenting with values for sustainability transformation (COEXIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Romania
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-17
End date: 2022-08-16
Duration (months): 24.0
Total project cost (EUR): 141778.56
EU funding (EUR): 141778.56
Participants: 1
Project status: CLOSED

There has been a growing discourse revolving around how sustainability science can reach the goal of transformational change in response to complex global problems such as climate change, biodiversity loss, and resource depletion. As one solution it has been suggested that sustainability science needs to bridge barriers to action by going beyond the co-production of knowledge to experimentation and testing of knowledge. At the same time, it has been argued that in order to achieve genuine transformational change it is necessary to shift values rather than simply generate ‘better’ actionable knowledge. COEXIST aims to join these two streams and to develop experimental settings that include values-based interventions to produce scientifically appropriate and socially relevant knowledge for sustainability transformations. Thus, COEXIST will be the first to integrate experimental interventions with the transformative power of values. I will identify theoretical frameworks that will inform a value-based experimental design and I will collect empirical evidence about key enabling factors and interventional practices that can operationalise such an experimental approach. By combining theory and practice, I will develop an integrated model of transformational experiments involving value-based interventions. I will implement the model within the real-world context of Transylvania, Romania, a region with a rich but threatened cultural and natural heritage. COEXIST combines my experience in transformational and transdisciplinary research modes and the host’s unique knowledge of place-based social-ecological systems research with the commitment of regional multi-sectoral stakeholders. This setup provides a strong theoretical and empirical foundation for the integrated model, which is expected to generate impact, and acts as a forum for communicating results to non-academic actors in Romania and Europe.

Keywords: sustainability science,transdisciplinary methods,sustainability transformation,transformational experiment,social ecological system,transcedental values,transformational knowledge
White Light-Emitting Diodes Based on Organometal Halide Perovskites (WLEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-30
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: SIGNED

Recently, perovskite light-emitting diodes (LEDs) have emerged as a new generation of efficient and low-cost LED technology because of their unique optoelectronic properties. Although great advances and exciting progress have been achieved in monochromatic perovskite LEDs, no white perovskite LED has been reported yet. This project targets the development of new white light-emitting perovskite (WLEP) emitters and high-performance white perovskite LEDs. Recent progress on Ruddlesden-Popper perovskites (RPPs) suggests a promising way for realizing WLEP thin films for high performance white LEDs. Therefore, in this project, I aim to develop efficient and stable white perovskite LEDs based on RPP thin films. Firstly, novel WLEP materials will be developed by using a strategy combining mixed A-site cations and rigid large organic cations. Secondly, high-quality WLEP thin films will be prepared through ‘cocktail’ approach-based additive engineering or/and post treatments. Ultimately, efficient and stable white perovskite LEDs will be fabricated by coupling new device architectures, device engineering and device physics. Also, the fellow will be trained to acquire new interdisciplinary knowledge and skills and to achieve professional maturity by implementing the project. The expected results of this project will considerably advance the research field of perovskite LEDs, consequently promoting the academic reputation of the host organization, ensuring EU’s dominant role in the research field of perovskite optoelectronics and enhancing the international impact of EU. Meanwhile, the expected outcomes are new WLEP materials and white perovskite LEDs which have great potential for commercialization. In the long term, commercialization of efficient and low-cost white perovskite LEDs will reduce energy consumption of lighting, helping reach EU’s energy saving targets, and can also generate economic growth and new job opportunities.

Keywords: electronics,semiconductor,lighting application
Fashion’s Responsible Supply Chain Hub (FReSCH): Investigating a just transition to a low-carbon circular fashion industry (FReSCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

The fashion industry is harming the environment and is also creating psychological and health impacts for workers due to poor working conditions and human rights abuses. Much of the focus of the fashion industry is on environmental sustainability with social sustainability largely ignored. There are trade-offs not only between business goals and sustainability but also between environmental and social sustainability practices. Ensuring environmental sustainability requires a parallel focus on justice and fairness. This action will contribute to the thematic European Commission priorities in terms of building a climate-neutral, fair and social Europe, and sustainable fashion value chains. It will research the optimal strategies for a just, fair and inclusive transition to a low-carbon circular fashion industry. This action is one of the first to investigate economic, environmental and social sustainability to understand the trade-offs, tensions and outcomes between these three in the transition to a low-carbon circular fashion industry. By using a novel methodology, simultaneous multi-level action research, this action will take a top-down and bottom-up perspective by examining a fashion supply chain in transition, H&M and its suppliers, in a country characterised by complex economic, environmental and social issues, Turkey. Action research in H&M will be instrumental in understanding the development of strategies and resources to cascade environmental and social sustainability practices throughout its supply chains. While, action research with suppliers, ‘Worker Circles’, will uncover the realities of SME suppliers and the outcomes of economic and environmental demands on working conditions and human rights practices to enable worker self-determination to solve problems in unique context-specific and customised ways.

Keywords: sustainability,sustainability transition,supply chain management,fashion industry
RISEWISE -RISE Women with disabilities In Social Engagement (RISEWISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Spain,Italy,Italy,Italy,Italy,Türkiye,Slovenia,Sweden,Portugal,Portugal
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-09-01
End date: 2021-02-28
Duration (months): 54.0
Total project cost (EUR): 1809000.0
EU funding (EUR): 1809000.0
Participants: 18
Project status: CLOSED

Women with disabilities have more difficulties to find an employment and to integrate in social day life activities than men with disabilities. This project focuses on the collective of women with disabilities from different perspectives, trying to identify needs and best practices in several EU countries, representing different cultural and socio-economic environments, for the integration and improvement of their quality of life in several respects. By applying a novel analysis method, based on the experience acquired by the exchange of researchers, innovation staff and practitioners in the European area among the participating institutions, the project will identify a set of multi-sectorial research lines, to enhance integration and involvement of this population in the society along several dimensions. The delimitation of the scope of the project to this sector of the population has several advantages. First, it is the first relevant study at a global scale that is performed in Europe on this collective. Second, it allows putting into practice and validating a novel social research method, with a strong multidisciplinary approach, with such a well delimited case study. novel potential research lines can be explored in different settings to assess their opportunity and feasibility. Fourth, it will show the impact that this collective may have on a sustainable growth in economy and society, from different respects, by empowering their capacities, so far undervalued. Fifth, it will establish a platform for cooperation among research groups and associations in EU that are aware of the situation of this collective, looking for their synergies. It is worth mentioning that advances on technologies and measures towards a stronger social engagement of disabled people have finally a positive impact also in the whole population as many examples show on how solutions have been transferred to the rest of society in fields such as computer interfaces, ergonomic solutions, etc.

Keywords: disability,gender issues,social inclusion,social exclusion,women
European Ways Forward for Space Traffic Management (SPACEWAYS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Spain,Italy,Austria,Belgium,France,France,France,France,Netherlands
Call: Space traffic management (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 1498470.07
EU funding (EUR): 1498470.07
Participants: 18
Project status: CLOSED

SPACEWAYS intends to create a common understanding of the guidelines and standards necessary to develop a Space Traffic Management (STM) concept for the European Union (EU). It also aims to assess European technical available and required capabilities (notably in the field of SSA/SST technologies) with respect to STM requirements; and to provide a set of STM best practices and recommendations in line with EU interests. This includes the preservation of a safe, secure and sustainable space environment as well as the reinforcement of European sovereignty and competiveness. Over its 18-month duration, SPACEWAYS’ first objective will be to analyse the policy, legal and economic context of STM. It will aim to better understand the STM concept’s dynamics worldwide and its consequences for Europe. While key space powers may attempt to create norms and regulations for future STM, SPACEWAYS intends to provide guidelines to support European policy making thereupon. In parallel, another goal will be to assess European capabilities and technology gaps with respect to future STM requirements. SPACEWAYS will identify stakeholders and users’ needs by associating them to the project through a networking platform. It will also proceed to a complete analysis of technical needs defined by future STM possible regulations. Both SSA/SST capabilities and technological developments related to new space missions and functions will be analysed. Here, specific attention will be devoted to mega constellation management, on-orbit operations or launch and re-entry future activities. These parallel lines of work will converge to produce a set of STM guidelines and best practices fully compatible with EU interests. They will be disseminated to relevant communities, to support the EU, as a major space and economic actor, to address future STM challenges.

Keywords: space traffic management,competitiveness,norm,space surveillance and tracking,new space,satellite constellation,cubesats,data,space security and safety,space resources,space operations