Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Single cell genomic analysis and perturbations of hematopoietic progenitors: Towards a refined model of hematopoiesis (HemTree2.0)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Hematopoiesis is an important model for stem cell differentiation with great medical significance. Heterogeneity within hematopoietic progenitor populations has considerably limited characterization and molecular understanding of lineage commitment in both health and disease. Advances in single-cell genomic technologies provide an extraordinary opportunity for unbiased and high resolution mapping of biological function and regulation. Recently we have developed an experimental and analytical method, termed massively parallel single-cell RNA-Seq (MARS-Seq), for unbiased classification of individual cells from their native context and successfully applied it for characterization of immune and hematopoietic progenitors. Here, we propose to uncover the hierarchy and regulatory mechanisms controlling hematopoiesis by combining comprehensive single-cell RNA-Seq analyses, modelling approaches, advanced functional assays, single-cell CRISPR screens, knockout models and epigenetic profiling. Exciting preliminary result show that indeed our approach is starting to uncover the complexity of hematopoietic progenitors and the regulatory circuits driving hematopoietic decisions. We will pursue the following aims: (i) Generate a refined model of hematopoiesis by comprehensive single-cell RNA-Seq profiling of hematopoietic progenitors, (ii) validate the predicted model by in vivo functional developmental assays and then (iii) test candidate transcription and chromatin factors uncovered by our model for their role in controlling progression towards various lineages using single-cell measurements combined with CRISPR screens. Together, our study is expected to generate a revised and high-resolution hematopoietic model and decipher the regulatory networks that control hematopoiesis. Our methods and models may provide a platform for future medical advancements including a large-scale European collaborative project to discover a comprehensive human hematopoietic tree.

Keywords: hematopoiesis,single cell genomics
Libiguins: a remedy for the treatment of sexual dysfunctions (LIBSED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will develop a business plan to guide clinical development and commercialization strategies for DIC2024, a novel drug candidate for the treatment of the common types of sexual dysfunction (SD): erectile dysfunction (ED) and premature ejaculation (PE) that affects 2 billion men worldwide. SD has serious implications on quality of life and is a significant socioeconomic burden. Current standard-of-care includes the use of PDE-5 inhibitors for ED and limited options for PE. The available treatments do not give long effect duration and therefore a major criticism is their inability to facilitate a more natural sex life that does not require planning every time a couple wants to have sexual intercourse. This is also related to delayed efficacy (15-60 mins) when using PDE-5 inhibitors. Accordingly, Dicot has developed DIC2024 that utilises a principle from a plant called Libiguin. Libiguin exerts a slow-onset, long-term action on the CNS’s integrative control systems for sexual behavior, which in turn controls spinal neuronal efferents that control erection and sexual behaviour. It also includes integration of afferent stimuli (tactile, visual, auditory). DIC2024’s uniqueness therefore lies in its potential to induce long term effects to tackle SD. The preclinical work performed to date includes development of the production protocol and studies to characterize the compound. Coupled with ethnopharmacological data (traditional medicine practiced by ethnic groups) supporting clinical use of Libiguin in men with SD, there is significant promise for the use of DIC2024 in the treatment of ED and PE. The proposed project will further prepare DIC2024 for a first-in-human clinical trial. SME Instrument funding will allow Dicot to take substantial steps along the path of commercialisation.

Keywords: sexal dysfunction,erectile dysfunction,premature ejaculation,libiguins
Seasonal Temperatures and Acidification of sensitive Marine settings: Insight of an uNmatched macro-invertebrate Archive. (STAMINA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-07
End date: 2023-04-06
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The seasonal pCO2 difference has globally increased, implying stronger stress for marine organisms sensitive to pH. This mechanism is reinforced by an overall increase in the seasonal cycle of sea surface temperature (SST), but it would be striking to understand its extent and effect on ocean acidification. Unfortunately, no records exist to evaluate long-term SST-pH dynamics. With this training-through-research project, the Experienced Researcher (ER) will gain the first record of seasonality, coupling SST and pH, for the Late Palaeozoic Ice Age demise, which is analogous to the current climate changes. After calibrating a method to investigate the seasonality in the modern brachiopods’ shells, he will extract seasonal time series of SST and pH from key fossils. Comparing the long term series of the deep past with the recent, the ER will foster the discussion and the understanding about the expected future changes for this chemico-physical system. The employed method will provide a classic model to deal with high resolution paleoenvironmental data using the brachiopods archive, establishing a turning point for the next-generation of scientists, which aim to study deep-past climate variability with high resolution. The University of Cambridge is an outstanding host where the researcher will be included in a high-level team of experts in geosciences. Under the mentor of the supervisor, the ER will gain and transfer relevant knowledge related to population structure and growth of shelled invertebrates, shell morphology, geochemistry and statistics. He will disseminate and communicate the results of his research and he will perform outreach activities to increase the attention of the society about problems concerning climate changes. At the host, he will be involved in training activities aimed to develop transversal and transferrable skills, to complete his formation as scientist, being thus ready for the next stage of his career.

Keywords: brachiopods,sclerochronology,sea surface temperature,ocean acidification,seasonality,shell accretion,climate proxies,stable isotopes
Bridging the gap between Mind, Brain and Body: exosome role and monitoring (MindGAP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Finland,Sweden,Finland,Portugal,Portugal
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 4435830.0
EU funding (EUR): 4435830.0
Participants: 6
Project status: SIGNED

MindGAP presents a radical new vision that may BRIDGE the GAP between HEALTH status and MIND/BODY interactions and lead to a paradigm shift in medicine. The disruptive idea presented herein is sustained by relevant data presented in the literature: (i) exosomes circulate throughout the body as messengers of health and disease, transporting genetic data to be delivered into a recipient cell; (ii) and exosomes are implicated in brain activity, having the ability to cross the blood brain barrier. Thus, when exosomes circulate and exit the brain to peripheral cells, there is a message transported therein, which is related to its cargo inside the vesicle. Overall, we aim to know which cargo is related to health and which cargo is related to disease. Traditionally, everyone has been looking for disease indicators to detect disease. Herein, we look for sensitive health indicators that may change under disease installation, therefore yielding an unprecedented early disease detection possibility. Moreover, the possibility of using MINDFULNESS meditation as a mind-related tool to control the cargo of exosomes is explored herein. If meditation is successful in changing the behaviour and attitudes of many people, fighting depression, etc., it means that the exosomes cargo may be changed through this process. Thus, this could be a major route to a self-healing approach before disease begins. Finally, all this knowledge opens doors to an innovative device that may be used by everyone to understand his/her health status. Overall, MindGAP targets (i) the missing relation between the genetic data in EXOSOMES and health status; (ii) interfacing this link with MIND-related activities; (iii) and to create an INNOVATIVE and PORTABLE DEVICE that TRACKS EXOSOMES and ANALYSIS their relevant genetic data, thereby allowing each individual to correlate this information with their own HEALTH STATUS and the installation of a pro-active attitude of each one of us against disease.

Keywords: mind and body interaction,extracellular vesicles,plastic antibodies,bio monitoring,personalized medicine
Smart grid competence hub for boosting research, innovation and educational capacities for energy transition (SMAGRINET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Estonia,Germany,Germany,Estonia,Lithuania,Slovenia,France,Portugal
Call: Research, innovation and educational capacities for energy transition (H2020-LC-SC3-2018-NZE-CC, 2018)
Start date: 2019-04-01
End date: 2022-03-31
Duration (months): 36.0
Total project cost (EUR): 1999750.0
EU funding (EUR): 1999750.0
Participants: 9
Project status: CLOSED

SMAGRINET engages 9 organizations from 6 countries: 6 high-level energy education and research institutions (2 involving their SSH institutes), an electricity industries union, strategic planning, an innovation management and RRI consultancy and a professional communications agency. Strategic objective of SMAGRINET is to develop a generation of researchers and engineers who are equipped to develop, improve and deploy new energy technologies in order to meet the challenges of the energy transition. Direct objective: to create smart grid competence hub for enhancing the capacities of the European universities in energy research, innovation and education and engage with industry, cities, regions and other key societal actors. Operational objective: to update, develop and implement a capacity building programme for boosting the research, innovation and education for energy transition. The objectives will be achieved by implementing a set of 6 WPs with the following main outputs: • Operation of the competence hub for collaboration and knowledge sharing, defining and validating the matrix of key challenges and cases in the smart grid area to be addressed by the capacity building programmes; • A set of 3 challenge and case-based modules (prosumers, connections, price and society) for master students (MA, MSc or ME) involving SSH and industry, complemented by simulation session and international mobility to the enterprises; 240 master students educated in the 2 rounds of piloting; • 3 short-term (3 months) blended learning programmes addressing the urgent skills needs with 720 participants (240 from each target group) in the 2 rounds of piloting; • Online trainers´ methodological manuals, 50 trainers trained as part of the train the trainers' pilot ready for replicating the modules and/or blended learning programmes; • Dissemination and communication programme reaching out at least to 100 energy communities, 5.000 related stakeholders and 100.000 general public.

Keywords: smart and flexible energy systems,renewable energy,energy storage smart grid,energy transition,cooperation network,case based modules,short term programmes,student mobility
3D Scaffolds as a Stem Cell Delivery System for Musculoskeletal Regenerative Medicine (CELL HYBRIDGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Aging worldwide population demands new solutions to permanently restore damaged tissues, thus reducing healthcare costs. Regenerative medicine offers alternative therapies for tissue repair. Although first clinical trials revealed excellent initial response after implantation of these engineered tissues, long-term follow-ups demonstrated that degeneration and lack of integration with the surrounding tissues occur. Causes are related to insufficient cell-material interactions and loss of cell potency when cultured in two-dimensional substrates, among others. Stem cells are a promising alternative due to their differentiation potential into multiple lineages. Yet, better control over cell-material interactions is necessary to maintain tissue engineered constructs in time. It is crucial to control stem cell quiescence, proliferation and differentiation in three-dimensional scaffolds while maintaining cells viable in situ. Stem cell activity is controlled by a complex cascade of signals called “niche”, where the extra-cellular matrix (ECM) surrounding the cells play a major role. Designing scaffolds inspired by this cellular niche and its ECM may lead to engineered tissues with instructive properties characterized by enhanced homeostasis, stability and integration with the surrounding milieu. This research proposal aims at engineering constructs where scaffolds work as stem cell delivery systems actively controlling cell quiescence, proliferation, and differentiation. This challenge will be approached through a biomimetic design inspired by the mesenchymal stem cell niche. Three different scaffolds will be combined to achieve this purpose: (i) a scaffold designed to maintain cell quiescence; (ii) a scaffold designed to promote cell proliferation; and (iii) a scaffold designed to control cell differentiation. To prove the design criteria the evaluation of stem cell quiescence, proliferation, and differentiation will be assessed for musculoskeletal regenerative therapies.

Keywords: scaffolds,additive manufacturing,stem cells,regenerative medicine
Energy efficient High Performance Computing (EeHPC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Qarnot computing aims to develop a flexible High Performance Computing grid able to reuse the heat emitted by calculation units for the heating purposes of houses and business premises. Regularly, huge data centers are opened for storage or calculation of numerical data. Needs, including calculation power, are becoming increasingly important, which explains the creation and implementation of more and more of these data centers. However, the past few years have shown that these clusters are particularly energy-consuming not only because of the calculations but also because of the cooling systems. The idea is to sale processing power on the cloud. The calculations are smartly distributed to a remote computing grid. The grid is composed of calculation units that are actually electric heaters. The heat is produced by the processors that perform the computing. Qarnot computing sales cloud HPC on one end, and refunds the electricity used by electric heaters on the other end. This solution allows Qarnot to build progressively a scalable computing grid avoiding the massive investments of a data center. Furthermore, there is no need to cool the infrastructure as the heat is directly used for heating purposes. Seasonality has already been taken into account by using CPU low power mode, install calculation units in strategic hosts such as schools that are closed during summer. In addition, computing power demand is seasonal, there is less jobs to perform during summer. Qarnot computing grid will be able to guarantee all year long a certain capacity, the extra power will be offered for free to universities and will be used as an adjustment variable (to meet the needs for calculation and the needs for heat). Qarnot can therefore propose a very energy efficient cloud HPC for reasonable prices. This is one key to address the HPC market which already represents billions of euros. Qarnot will be able to propose greener cloud HPC for lower prices than the competitors.

Keywords: cloud hpc,grid computing,energy efficient computing,distributed grid,scalability,reduced carbon footprint,free heating,connected heater,digital heater,cheapest cloud hpc
Triangulum: The Three Point Project / Demonstrate. Disseminate. Replicate. (Triangulum)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Norway,Norway,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Smart Cities and Communities solutions integrating energy, transport, ICT sectors through lighthouse (large scale demonstration - first of the kind) projects (H2020-SCC-2014, 2014)
Start date: 2015-02-01
End date: 2020-01-31
Duration (months): 60.0
Total project cost (EUR): 29507946.58
EU funding (EUR): 25420602.29
Participants: 28
Project status: CLOSED

The Triangulum project will demonstrate how a systems innovation approach based around the European Commission’s SCC Strategic Implementation Plan can drive dynamic smart city development. We will test the SIP across three lighthouse cities: Manchester, Eindhoven and Stavanger, which represent the main typologies of European cities. They will be complemented by our follower cities Prague, Leipzig and Sabadell. This powerful combination reflects an urban population of between 100k and 1,2m inhabitants across six different countries, allowing us to demonstrate successful replication across a wide range of typical urban areas in Europe. Each city has already made significant progress towards the transition of becoming a smart city; developing their own individual approach reflecting specific local circumstances. These inherent strengths will now serve to accelerate the smart city development across proposed demonstration sites within Triangulum. The suite of projects developed will be based around zero/low energy districts, integrated infrastructures and sustainable urban mobility designed to deliver a range of cross-cutting outcomes across different sectors and stakeholders. This will provide the basis to ‘road test’ the SIP and provide recommendations to the Commission on how it could be improved to facilitate wider replication. The Triangulum goals target a series of direct impacts around; reduced energy consumption of buildings, increased use of renewable energies, increased utilisation of electric vehicles, deployment of intelligent energy management technologies and the deployment of an adaptive and dynamic ICT data hub. The design and implementation of innovative Business Models and the activation of citizens as co-creators are core cross-cutting elements to base the technologies in real-world city environments and facilitate replication.

Keywords: triangulum,zero,low energy districts,transitions,smart city,demonstrate,disseminate,replicate,morgenstadt,citizen integration,co creation,integrated infrastructures