Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Single-molecule tracking for live-cell protein synthesis kinetics (SMACK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1653550.0
EU funding (EUR): 1653550.0
Participants: 1
Project status: SIGNED

This project aims to map the determinants of efficient synthesis, folding, and targeting of proteins in living bacterial cells, and to understand how antibiotic drugs inhibit these events. Our findings will be used to form a quantitative description of how the mRNA sequence ultimately determines how, where, and when a polypeptide should fold, which will help to design better E. coli-based production systems for recombinant proteins; both protein folding and targeting are currently severe bottlenecks. Further, by studying the effect of clinically relevant antibiotic drugs directly on ongoing protein synthesis, we will learn how the inhibitory action on the molecular level is translated into the response on cell and population level. This knowledge will help to improve the use of current drugs, as well as to provide clues regarding how new drugs should be designed. To reach our goals, we will use and further develop our recently published fluorescence-based experimental and analytical system for live-cell single-molecule analysis of protein synthesis kinetics. Particularly, we will develop orthogonal translation systems to measure protein synthesis kinetics on defined mRNAs in an unperturbed cell background. We will also label and study key components of the universal pathway for Signal Recognition Particle-mediated cotranslational targeting of peptides to the membrane-bound peptide translocation complexes. In these applications we use small organic dyes for site-specific labeling of molecules, which allow recording of long diffusion trajectories inside cells. These trajectories are then fed to our machine-learning algorithms to deduce the binding kinetics. With an increasing demand for therapeutic proteins, such as monoclonal antibodies for cancer treatment, there is an urgent need for microbial-based systems for cost-effective production of recombinant proteins. With our unique experimental and analytical system, we have the opportunity to aid in this development.

Keywords: single molecule tracking,kinetics,polypeptide targeting,signal recognition particle,antibiotics
MagIC – Magnonics, Interactions and Complexity: a multifunctional aspects of spin wave dynamics (MagIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ukraine,Spain,Poland,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 756000.0
EU funding (EUR): 756000.0
Participants: 9
Project status: CLOSED

The artificial patterning of nanoscale structures provides an excellent opportunity for modifying spectra of their excitations, and therefore for designing materials with unforeseen properties. Newly created materials (photonic, magnonic or plasmonic) serve as promising candidates for technological applications in integrated devices with smart functionalities for optoelectronic applications, nanoscale thermal transport control, charge free storage and manipulation of information. Magnetic materials with periodically modulated properties, magnonic crystals (MCs) offer two main distinctive features from which the technology can benefit. Firstly, MCs facilitate tunable excitation spectra controlled via magnetic field. Secondly, being non-volatile materials they facilitate exploitation of the re-programmable properties. Hence, significant international research effort in MagIC is now devoted to the area of magnonics and its cross disciplinary opportunities with photonics, phononics and electronics. The frontiers of new ideas, pushing the limits of knowledge, will be developed. The most prominent directions of research are the exploration of nonlinear effects in MCs, tailoring effective damping, developing theoretical models of the spin wave scattering in nanoscale, investigating effects of the broken periodicity and fractal structures on magnonic spectra. Moreover, MagIC will exploit still unexplored directions of mutual coexistence of magnonic functionalities with these of photonic, plasmonic or phononic in a single nanostructure. The academic exchange (168 months of visits in 4 years) supplemented with abundant network and outreach activities will aim to continue existing collaboration, establishing new links, supporting multilateral transfer of knowledge and expertise among seven European and Ukraine research teams, striving to advance the aforementioned research fields, development of innovation and career for research and innovation staff members.

Keywords: magnonics,spin waves,nanomagnetism,magnonics photonics,magnonics phononics
Contested Waters: Rio de Janeiro’s Public Water Supply and the Social Structuring of the City (CONTESTEDWATERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The objective of the project is to write a social and political history of colonial and imperial Rio de Janeiro (16th to 19th centuries) along the lines of its expanding water supply. It is based on the assumption that the access to and control of water were closely related to the social and political struggles and structures in the city. Although not particularly scarce in its occurrence, due to the special geological situation, water and the water supply have always been more contested in Rio de Janeiro than in many other cities. Therefore water, with its highly transient availability but continuous relevance for all parts of society, is a topic suited to uncover important aspects of urban history, for specific situations as well as for broader developments, and ultimately for understanding how European rule in the overseas empires was constantly and extensively challenged by local circumstances. Furthermore, the project will give a response to the theoretical question about the relevance and applicability of environmental history to other fields of history, and encourage a more reflected and socially engaged thinking about some of the most pressing problems of our current world: the property, control and management of water – and harmful potential which can emanate from it.

Keywords: brazil,city,colonial history,19th century,water,environment,spatial development
An innovative external brace to ensure patency and maturity of arteriovenous fistulas in haemodialysis patients. (VasQ)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Arteriovenous Fistulas (AVF), the process of joining a vein to an artery, is the gold standard for both vascular access (VA) and haemodialysis (HD) in end-stage renal disease (ESRD) patients; however, the procedure is fraught with post-surgical complications, leading to a 65% rate of usability 3-months after the surgery. VasQ is an external support device which wraps the vein to provide structural support, and braces it against the artery to improve flow properties; hence, it presents a drastic improvement over both conventional AVF procedures and the competing alternative technologies. By providing structural support to the vein in the AVF, and bracing the site where the artery and vein are joined at an optimal angle, VasQ prevents the complications relating to a vein being subjected to arterial conditions (stenosis, aneurysm, rupture), and the flow-pattern problems (thrombosis, shear force complications). VasQ improves the maturation success rate to 87% at 3 months and has shown a 3x improvement in flow rates of the AVF over the accepted minimum standard for maturation, and a 60% improvement in venous diameter over the accepted minimum standard within 3 months. The implementation of VasQ does not alter the AVF procedure, ensuring that the surgeons do not need to learn a new work process. Overall, VasQ provides repeatable, superior results to both unsupported AVF’s and alternative procedures, and improves the long-term usability of AVF’s, which reduces the cost to patients and healthcare providers.

Keywords: dialysis,arteriovenous fistulas,improved clinical outcomes,medical device,implant,nitinol
COproductioN with NaturE for City Transitioning, INnovation and Governance (CONNECTING Nature)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Ireland,Spain,Ireland,Italy,Armenia,Germany,Germany,Germany,Italy,Cyprus,Bosnia and Herzegovina,Poland,Romania,Korea, Republic of,Belgium,Bulgaria,Greece,Greece,Slovenia,China,Georgia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Demonstrating innovative nature-based solutions in cities (H2020-SCC-NBS-2stage-2016, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 11768009.61
EU funding (EUR): 11394282.48
Participants: 40
Project status: CLOSED

The overarching objective of Connecting Nature is to position Europe as a global leader in the innovation and implementation of nature-based solutions. The project partners will form a community of cities fostering peer-to-peer, transdisciplinary capacity-building between front-runner, fast-follower and multiplier cities. Connecting Nature will co-develop the policy and practices necessary to scale up urban resilience, innovation and governance via nature-based solutions. An open innovation ecosystem approach bringing together city governments, SMEs, academia and civic society will be used to co-produce usable and actionable knowledge in all cities. Connecting Nature will provide the reference framework for a new generation of urban nature-based solution processes and empower transitioning ambassadors who will globalise this approach through a strategy targeting multiplier cities. This novel approach, coupled with the high capacity of the consortium, makes Connecting Nature an exciting prospect. In addition, linking all open-sourced data to the Oppla platform will ensure perpetuation beyond the end of the project.

Keywords: nature based solutions,transdisciplinary methodology,urban communities,front runner cities
Advancing materials design by high-accuracy finite-temperature first principles calculations accelerated by machine learning potentials (Materials 4.0)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Phase diagrams have revolutionized materials development by providing the conditions for phase stabilities and transformations, and thereby a thorough thermodynamic understanding of materials design. However, the majority of today’s phase diagrams are based on scarce experimental input and often rely on daring extrapolations. Every multicomponent phase diagram relies on a fragile set of phase stabilities as very recent studies show. Materials 4.0 will change this. It will raise materials design to the next level by providing a highly accurate first principles thermodynamic database. First principles, alias ab initio, approaches do not require any experimental input and can operate where no experiment is able to reach. However, they have been limited to zero Kelvin or low temperature approximations which are not representative of phase diagrams. Materials 4.0 reaches far beyond this by utilizing my unique expertise in high-accuracy finite-temperature ab initio simulations. We will develop novel methods accelerated by machine learning potentials that facilitate a highly efficient determination of Gibbs free energies and migration barriers including all relevant finite-temperature excitation mechanisms. The methodology will be implemented in an easy-to-use open-source integrated development environment and made accessible to the community. Materials 4.0 will consider materials relevant to current scientific developments and of technological interest, such as hydrides, lightweight alloys, superalloys, MAX phases, and high entropy alloys. A large ab initio thermodynamic database will be computed for elements across the periodic table. The main focus will be on phase stabilities of various phases, including dynamically unstable ones, and importantly liquids as well; all fully from ab initio. The phase stabilities will be put into practice by re-parametrizing binary phase diagrams and studying the implications on multicomponent phase diagrams.

Keywords: phase diagrams,gibbs energies,ab initio,density functional theory,calphad,alloys,machine learning
INTERNATIONAL COORDINATION OF RESEARCH ON INFECTIOUS ANIMAL DISEASES (ICRAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: ERA-NET Cofund
Partnership: ICRAD (ERA-NET)
Countries involved: Germany,Spain,Estonia,Ireland,Italy,Germany,Italy,Greece,Switzerland,Norway,Türkiye,Belgium,Belgium,Lithuania,Poland,Sweden,Russian Federation,Hungary,Latvia,France,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark
Call: ERANETs in agri-food (H2020-SFS-2019-1, 2019)
Start date: 2019-10-01
End date: 2025-09-30
Duration (months): 72.0
Total project cost (EUR): 24442750.0
EU funding (EUR): 8066107.5
Participants: 34
Project status: SIGNED

This proposal seeks funding under the Horizon 2020 Work Programme to establish an ERA-NET for International Coordination of Research on infectious Animal Diseases (ICRAD). The scope for this ERA-NET has been developed under the SCAR Collaborative Working Group on Animal Health & Welfare Research (CWG AHW), which seeks to build further on 2 previous successful ERA-NETS (EMIDA, ANIHWA). 31 partners from 20 countries initially seek to support one co-funded call followed by other joint activities including the update of the EU Animal Health Strategic Research Agenda and the initiation of new international partnerships. Animal diseases cause severe social, economic and environmental damage and in some cases threaten human health as well. Disease threats to the livestock industry have increased in the last decades due to globalisation, altering production methods, climate changes and increased contacts between wildlife and livestock. Effective control tools or key knowledge leading to better control is still missing for many important livestock diseases, including for African Swine Fever and animal influenza which pose great challenges in Europe and globally. Partners in this ERA-NET will address these threats through joint European research within a framework which supports multi-disciplinary research in the fields of (i) fundamental understanding of host/(vector)/pathogen interactions and the epidemiology of disease; (ii) vaccinology and (iii) diagnostics. Research and innovation coordinated through ICRAD will (i) increase preparedness and ability to respond to emerging and endemic livestock threats; (ii) provide improved vaccines and diagnostic tools and strategies; (iii) contribute to the reduction of antibiotic and antiparasitic resistance; and (iv) contribute to animal welfare by better disease prevention. By reducing the burden of animal disease and its impact on international trade, ICRAD will enhance food security and sustainable livestock production.

Keywords: infectious diseases of animals,research and innovation,research coordination,vaccinology,diagnostics,disease prevention,antimicrobial resistance,african swine fever,animal influenza
Giga-Hertz Laboratory Experiment for Axion Dark Matter (G-LEAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2112093.0
EU funding (EUR): 2112093.0
Participants: 1
Project status: SIGNED

The nature of the dark matter, making up most of the mass of the universe remains a mystery. The G-LEAD project aims at building an original experiment to test one of the favorite hypotheses for what dark matter could be : axions. Axions have been hypothesized in the late seventies and have been extensively searched for ever since. They elegantly solve the strong CP problem of the Standard Model and constitute a natural candidate for dark matter. Axions are expected to be very light particles and they would mix with photons in an external magnetic field. If dark matter is made of axions, a metal/air interface in a magnetic field would emit GHz radio waves. I hereby propose to build the first experiment aimed at producing and detecting this axion-induced interface radiation. As opposed to all other experiments, the G-LEAD experiment is designed to be broadband, and its setup is based on a simple and robust design. It will likely constitute the world-leading experiment in terms of sensitivity in its mass range during the course of the project. Beyond the publication of candidate signals or exclusion limits on axion parameters, prototypes will be built in order to make a proposal for a large-scale broadband experiment. The project relies on a pathfinder experiment conducted at CEA Saclay and will benefit from existing local installations. Planned realizations include a new spherical cap, a large aperture 3 T magnet, modules of magnetized interfaces, new antennas and radiometers. Two postdoctoral fellows and a PhD student will be hired. An outreach and specialized workshop program is also proposed.
Develop an innovative computer system which understands contractual documents by applying artificial intelligence (Computer Linguist)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-12-01
End date: 2020-11-30
Duration (months): 12.0
Total project cost (EUR): 137500.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ginkgo Analytics want to develop a contract management solution which understands and interprets contracts from different sources (e,g. procurement, sales, projects, Human Resources). This solves the problem that contractual and legal knowledge is rarely available in sufficient capacity in most SMEs. Therefore a smart service is developed which is self-learning and understand contracts and provides legal advise. To achieve this goal an Innovation Associate is required which is capable to develop natural language processing algorithms using machine learning and deep learning technology. The solution can be used by all SMEs globally and can be applied to all contracts which manage value generation with a total volume of several Trillion EUR.

Keywords: machine learning,deep learning,natural language processing
Search for axion-like particle produciton in kaon decays at CERN-NA62 experiment (KaonToALP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-04
End date: 2023-07-11
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

It is proposed to perform the first search for production of a short-lived axion-like particle (ALP) in charged-kaon decays (K+ --> pi+a), which decaying promptly into a di-photon final state, using world's largest data set of charged kaon decays collected by the NA62 experiment at CERN in 2016-18. New powerful constraint on the ALP phase space will be established; a possible ALP discovery would be a breakthrough in particle physics. To achieve credible results on the ALP search, it is mandatory to understand the main Standard Model background process K+ --> pi+ gamma gamma. Therefore a comprehensive study of this process is also proposed, including a re-analysis of the inputs to the description of this decay within Chiral Perturbation Theory, and the most precise measurement of this process to date. This measurement by itself represents an important test of the theories describing low-energy dynamics. These novel measurements are based on an existing data sample collected recently, thereby minimizing the associated risks.

Keywords: rare decays,kaon decays,axion like particle