Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ENHANCING BIO-BASED INNOVATION AND PARTICIPATION IN UNDER-REPRESENTED REGIONS THROUGH CLUSTER MOBILIZATION AND COLLABORATIVE GOVERNANCE (BIO-INSPIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Coordination and support actions
Partnership: CBE (JU-JTI)
Countries involved: Greece,Belgium,Hungary,Portugal,Romania,Bulgaria,Poland,Spain,Sweden,Netherlands,Slovakia,Lithuania
Call: Mobilize inclusive participation in bio-based systems and supporting the CBE JU widening strategy and its action plan (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2999180.0
EU funding (EUR): 2999180.0
Participants: 14
Project status: SIGNED

Regional clusters are the unsung heroes of sustainable development, driving innovation and economic growth by leveraging local ecosystems and fostering strong connections among businesses, research institutions, and stakeholders. This is even more valid for Clusters in Bioeconomy, where new knowledge is born constantly The project´s collective understanding is that Regional Bio-Economy Clusters are ideally suited to mobilise R&I ecosystems, due to their cross-sectoral nature of bioeconomy in different countries, their proximity to local enterprises, and their ability to reflect common bottlenecks and needs and link the local ecosystem with international knowledge and funding hubs. BIO-INSPIRE, an alliance of 14 transdisciplinary entities from 12 EU countries, demonstrates that regional bio-economy clusters are a valid answer to developing bio-based innovations, driving sustainable growth and fostering resilient local economies across the widening regions of Eastern and Southeastern Europe. BIO-INSPIRE will engage Regional Bio-Economy Clusters in 7 widening countries (Greece, Hungary, Slovakia, Lithuania, Romania, Bulgaria and Poland, ) and research and technology developers and clusters in 2 non-widening countries (Sweden, The Netherlands) to address systemic causes of underdevelopment across geographical boundaries. BIO-INSPIRE aims to contribute to the transformation of the widening regional bioeconomies by addressing existing bottlenecks and providing to the regions the necessary tools to advance their R&I capacity and their ability to broader their collaboration networks. At the heart of this project is the provision of a Governance Model framework, addressing the critical lack of established structures, norms, and procedures for sustainable collaboration. This framework is designed to be a long-lasting legacy, empowering also other regions to achieve sustainability and growth, and ensuring their effective and enduring engagement in the bio-based economy.

Keywords: cluster mobilization regional bio economy clusters widening increased randi
Platform Level Bureaucracy and Social Inclusion (PERSON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2029-06-30
Duration (months): 36.0
Total project cost (EUR): 341683.08
EU funding (EUR): 341683.08
Participants: 2
Project status: SIGNED

PERSON - Platform Level Bureaucracy and Social Inclusion PERSON analyses what happens to the bureaucratic encounter and to street level bureaucrats’ (SLBs) discretion when access to service becomes digital. Studying the use of three platforms for accessing Job Centres activated in Italy (DID Platform), Canada (Québec.ca Platform), and the Netherlands (UWV Platform), PERSON investigates the way in which digital bureaucratic encounters affect SLBs’ discretion and aims to develop guidelines for an inclusive public platform design, overcoming barriers related to gender, age, and ethnicity. The core idea revolves around how digital practices change not only the way SLBs use their discretion, but also the very nature of the bureaucratic encounter between users and SLBs, consequently, it appears necessary to investigate the relationship between these two actors, mediated by digital public platforms. The research will be conducted in three countries with three different levels of digitisation of the public sector, through the implementation of creative and replicable tools for digital qualitative research (Digital Subsystem Technique; Vignette Techinque for Internet Based Research). PERSON wants to understand whether the digital bureaucratic encounter amplifies or reduces the effects of the characteristics of the actors (SLBs and users) on the actual access to the public service. The final objective is to develop guidelines to design an inclusive platform for the public sector by comparing similar platforms in three different digitisation contexts.

Keywords: street level bureaucracy bureaucratic encounter digitalization of public sector public administration social inclusion public platform qualitative research vignette gender studies sts studies
Aristotle One and Many. The Arabic Pseudepigrapha (ArOMa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1555956.0
EU funding (EUR): 1555956.0
Participants: 1
Project status: SIGNED

The present project is focused upon a group of seminal sources, part and parcel of the formation of intellectual discourse in the Middle Ages, and forming a common basis of understanding between the cultures on both sides of the Mediterranean, until the today. One of the prominent features of Medieval Aristotelianism, both Arabic and Latin, is the fact that Aristotle has been credited with writings that, albeit different in origin and sometimes of differing philosophical affiliations, circulated under his name. The Project Aristotle One and Many. The Arabic Pseudepigrapha (ArOMa) is focused on the works falsely attributed to Aristotle in the Arabic philosophical literature translated or forged in the 9th-10 cent. The corpus of ‘Pseudo-Aristotelica Arabica’ includes two categories of texts: A. Arabic versions of works falsely attributed to Aristotle already in Greek. B. Medieval Arabic forgeries. To these will be added: C. Commentaries on such works (including abridgements, paraphrases etc.). The aim is to provide a new insight into the Arabic Aristotle through the first overall treatment of the Arabic Pseudo-Aristotelica, including an inventory of the manuscript sources, editions and translations of the most relevant items, tools and studies towards a better understanding of Aristotle’s reception in the Arabic-speaking world. Also the Latin versions of such pseudepigrapha will be taken into account. It is still uncertain how many works falsely attributed to Aristotle are mentioned in the Arabic sources, how many have survived or have been lost. Few have been edited or translated. ArOMa fills this gap, adding a new dimension to the standard historiographical accounts. We expect to provide a more complex, and unorthodox image of Aristotle’s facets presenting an engaging and thorough history of the Aristotelian philosophy during the centuries which correspond to the Latin Middle Ages.

Keywords: arabic aristotle,history of medieval philosophy,arabic pseudo aristotelica,aristotelianism in the arabic tradition,late ancient commentators
A Design Principle for Predicting Flexible Metal-Organic Frameworks (FlexiMOFs-2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Metal-organic frameworks, MOFs, are porous organic-inorganic hybrid materials that hold the potential for developing new technologies to tackle some of the pressing global challenges such as pollution, climate change and energy crisis. Their typical low mass densities, high internal surface area, large pore volumes and facile chemistry makes them suitable for application in gas storage, filtration, extraction, catalysis and so on. Some MOFs are known to show a substantial degree of structural flexibility wherein the framework reversibly expands/contracts when subjected to external stimuli like pressure/heat/light or during absorption/desorption. This structural flexibility, if fully understood, can be used to enable the technological development of MOF-based recyclable filters, switchable catalysts, threshold sensors, stimulus-induced drug delivery systems with integrated key-lock functionality, compressible gas tanks and so on. However, the origin of this flexibility has not yet been sufficiently understood to enable the rational design of flexible MOFs. This research project aims to provide a conceptual understanding on the origin of this flexibility at the atomic regime by analysing all unique building units, topologies, and frameworks of all published MOFs to design a universally robust metric for predicting flexibility and mechanical properties of MOFs with the overarching goal of providing a theoretical methodology for the crystal engineering of flexible MOFs.

Keywords: metal organic frameworks mechanical properties flexibility machine learning judgement of energy distribution analysis prediction
Light4Switch: Conformational Switch of Light-Harvesting Complexes Upon Illuminating Azobenzene (Light4Switch)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Plants can dissipate excess absorbed light energy as heat, by reversible switching of light-harvesting complex II (LHCII) into photoprotected quenched states, to prevent photodamage of photosynthetic apparatus. The conformational switch of LHCII is suggested to modulate the interaction between the embedded pigments, and consequently activate charge transfer and/or excitation energy transfer processes which ultimately lead to the dissipation of excess energy as heat, known as energy-dependent quenching (qE). Although the site of qE has been long established, i.e. the LHCII, the specific protein domains and conformational switches responsible for activating qE are currently unknown. This MSCA fellowship project AZO-LHCII aims to determine the role of the protein matrix of the LHCII in tuning their energetic state and driving the photoprotective switch of plants. To this end, this disciplinary project will for the first time strive to manipulate the conformation of LHCII antenna proteins with azobenzene photoswitches and use a novel multipulse transient absorption spectroscopy approach to study in real-time the effect of site-specific conformational fluctuations on the regulation of the excitation energy transfer in LHCII.

Keywords: azobenzene,ligh harvesting complex,transient absorption spectroscopy,energy transfer
Tuning Heat Transport in 2D Materials with Defects (HeaT2Defects)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The unstoppable race towards miniaturization is pushing the limits of electronics. This has to be conciliated with the inevitable Joule heating that affects all electronic devices, ultimately compromising miniaturization itself, as denser circuits require improved thermal management. Understanding and eventually controlling heat transport at the nanometer scale will lay the foundation for the design of present and future electronics, where the use of complex architectures and new nanomaterials, such as two-dimensional (2D) materials, holds a great potential. At such scales, atomic-scale defects, which are present everywhere in nature, play a fundamental role as just a single defect can greatly impact the properties of materials. However, our knowledge of the influence of an individual defect on heat propagation is surprisingly scarce. This is partly due to the limited spatial resolution of state-of-the-art thermal imaging. HeaT2Defects aims to explore the fundamental properties of matter at a much smaller scale than is currently possible, engineering the influence of defects (namely vacancies, ripples and unconventional stacking) on heat transport of 2D devices. To this end, hinging on my extensive experience in scanning probe microscopy, I will develop an imaging technique with pioneering advances based on atomic force microscopy (AFM), Raman spectroscopy and nanoheater engineering. The versatility and resolution of AFM plus the thermal capabilities of Raman will allow thermal mapping with nm precision, improving state-of-the-art resolution by one order of magnitude. This will enable a deep understanding of the influence of defects on heat transport, and ultimately the engineering of the striking properties of 2D materials as thermal management components, vital to avoid energy waste and device malfunction. Far-reaching implications are expected, both from the profound impact of heat transport in many scenarios and from the technological developments.

Keywords: atomic force microscopy,2d materials
Stochastic Geometry and Novel MAC Schemes for Enhanced Satellite IoT Networks (SATNET-IoT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Luxembourg
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 242116.8
EU funding (EUR): 242116.8
Participants: 2
Project status: SIGNED

The SATNET-IoT project addresses the significant challenges of extending IoT connectivity through satellite networks, particularly in remote areas where terrestrial coverage is insufficient. With terrestrial networks covering only 25% of the global landmass, satellite-based IoT solutions have become crucial for achieving any-time, any-device connectivity. The rise of non-geostationary orbit (NGSO) satellites, with their lower latency and improved data transfer speeds, offers promising opportunities for IoT communication. However, performing orbital simulations to know the exact locations of the satellites for each of them is time-consuming and computationally complex. Also, any new solution analysed based on specific satellite orbits cannot be generalized for other constellations. SATNET-IoT aims to utilize stochastic geometry for developing a mathematical framework to analyze the potential improvements in coverage across different regions and times offered by satellite networks, without requiring precise orbital data. The existing IoT communication protocols are also not designed to manage the dynamic, intermittent coverage inherent to satellite networks, nor do they account for the higher propagation delays and rapidly changing topology. SATNET-IoT aims to overcome these challenges by developing novel medium access control (MAC) layer protocols, ensuring efficient transmission scheduling and resource allocation within limited satellite visibility windows. The developed stochastic geometry framework and algorithms will be validated by deploying a real-time IoT network for air quality monitoring using software-defined radio to emulate satellite constellations.

Keywords: satellite communications,stochastic geometry,software defined radios,medium access control,routing protocols
In vivo metabolic imaging at low magnetic field (LF13CMRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Magnetic resonance imaging (MRI) is an excellent technique for medical diagnosis. Nonetheless, people from rural areas and low-income countries cannot access MRI due to its high associated cost. In recent years, low-field MRI has emerged as a potential solution to increase access to MRI, but at the cost of reduced signal sensitivity. This is a limiting factor in terms of resolution, traceable quantities of metabolites, and early detection of tumor tissue. In this context, hyperpolarization (HP) has emerged as the most promising technique to compensate for the sensitivity losses at low magnetic fields. HP can enhance signal intensity by >10,000 times, providing enough signal to image even species at low concentrations, such as metabolites internalized by cancer cells. Here, the first in vivo metabolic imaging methodology with hyperpolarization at low magnetic fields is proposed. The project involves the development of 1H and HP 13C MRI at low field, the study of enzymatic conversion from HP pyruvate to other metabolites, and in vivo metabolic tumor imaging in mice. Para-hydrogen-induced polarization (PHIP) will be used to generate the HP contrast agent. PHIP offers several advantages, including low costs, low instrumentation demands, rapid high-throughput, and scalable production of HP agents in the liquid state. The combination of low-field MRI with PHIP 13C has the potential to provide a method for early cancer detection in a low-cost scanner.

Keywords: mri,nmr,hyperpolarization,13c
Lysosomal exocytosis of metastable proteins to control synaptic function (LEXSYN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2037356.0
EU funding (EUR): 2037356.0
Participants: 1
Project status: SIGNED

The extreme length and small caliber of neuronal processes entail complex local regulation of protein turnover. In light of the high metabolic demand and dynamic protein exchange imposed by synaptic neurotransmission, several surveillance mechanisms should be in place to sense protein damage that will otherwise cause synaptic dysfunction. However, it is still essentially unclear how local control of the metastable proteome, whose proteins have a high copy number and are crucial for synaptic function, is accomplished in dendrites to prevent formation of toxic aggregates. My previous work suggests that neuronal activity drives lysosomal fusion with the plasma membrane and exocytotic release of supersaturated, aggregation-prone proteins. The deposition of these proteins in the interstitial space likely feeds into the glymphatic system and cleaning routines associated with the enhanced circulation of cerebrospinal fluid during sleep. Intriguingly, I could show that, the concomitant release of lysosomal proteases enables growth of spine synapses suggesting that lysosomal exocytosis might serve both, protein removal and synaptic plasticity, whereas the latter might be an inevitable consequence of the necessity for local disposal of aggregation-prone proteins. Building on my expertise in synapse biology and advanced imaging, the LEXSYN project aims to characterize the secretome of exocytotic lysosomes and to understand the consequences of dendritic lysosomal fusion for synaptic plasticity. I will decipher physiological signals regulating lysosomal exocytosis and investigate the pathological consequences of lysosomal fusion impairment, thereby assessing its relevance in neurodegenerative diseases. To achieve these ambitious goals, I will develop new tools for monitoring and manipulation of dendritic lysosomal exocytosis in vivo. I expect to reveal mechanisms of fundamental relevance for the control of the metastable proteome and its contribution to neurodegeneration.

Keywords: synapse,structural plasticity,lysosomal exocytosis,chaperone mediated autophagy,metastable proteome