Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases (bloodANDbone)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-12-31
Duration (months): 71.0
Total project cost (EUR): 1499920.0
EU funding (EUR): 1355804.54
Participants: 2
Project status: SIGNED

Blood and bone are closely intertwined. Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. Re-establishing the regenerative potential is the key to cure these diseases by regenerative medicine. Multipotent stem cells of both tissues – hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone – are the basis for their regenerative capacity. While it is well established that HSCs are influenced by the bone marrow in their natural environment including MSCs and their progeny, surprisingly little attention has been paid to the reciprocal relationship. The hypothesis of the current proposal is that only when taking both tissues and their mutual crosstalk into account, we will be able to understand how the regenerative potential of blood and bone is impaired in disease and how it can be re-established with novel treatment strategies. For this purpose we need to understand the early events of disease onset and progression. Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. This versatility will enable us to create biomimetic human in vitro models of the human bone marrow in health and disease, which are ground-breaking in their applicability to investigate how the regenerative balance of bone marrow is maintained in health and disturbed in the different kinds of diseases – a prerequisite to develop novel regenerative treatments – as well as their scalability and thus suitability as in vitro test systems for screening of novel drugs or treatments.
The next generation of internet-of-thing (IoT) connectivity. (DeviceHub)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Internet of Things – a vast network of smart objects which work together – is becoming a reality. The number of connected devices is forecasted to reach 50 billion units worldwide by 2020. A wide range of industries – auto makers, healthcare, airlines, banks, smart homes, public institutions or retail giants - are making their products available on various digital platforms. Estimated total IoT market size across all horizontal markets to reach €4.59 trillion by 2018. Today, upon creating an IoT development strategy companies either assemble an internal team that will develop the solution and applications platforms, or outsource the development of a custom built IoT platform to fragmented 3rd party development houses. The process is expensive and fragmented by lacks of standardization or a universal and scalable solution encompassing all aspects of the IoT ecosystem. SoA solutions inhibit IoT development for SMEs and inventors with high entry barrier, prolonged time-to-market and high developmental risks. DeviceHub.net is the first universal, open source ecosystem management platform (EMP) for IoT. We bridge the gap between hardware devices and mobile/web developers by providing a collection of straightforward tools to both ends. DeviceHub is scalable platform that allows SMEs or even single users with little coding or app development experience to create end-to-end IoT solutions with provided hardware, apps for iOS/Android/web and integrated data analytics, i.e. business intelligence (BI) tools, all under one umbrella of DeviceHub, at a fraction of the cost and time of currently available, fragmented solutions. The proposed project addresses the topic SMEInst-01-2016-2017, with the first commercially available, ‘end-to-end’ IoT ecosystem management platform. As a catalyst for innovation, our innovative scheme will disrupt the IoT industry with a unique product that will bridge the technological gap for IoT developers in both the public and private domains.

Keywords: internet of things,ecosystem,scale up,innovation
Development of Narrow Band Blue and Red Emitting Macromolecules for Solution-Processed Solid State Lighting Devices (NarrowbandSSL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-09-12
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

This project targets the development of solution-processable narrow-band thermally activated delayed fluorescence compounds that will be employed in low-cost solution-processed solid-state lighting devices. Solution-processed organic light-emitting diodes (OLEDs) and light emitting electrochemical cells (LECs) will be fabricated from these materials. The stringent design criteria will be met by adapting multi-resonant thermally activated delayed fluorescence materials to be compatible with solution processing techniques. Using the proposed design it is expected that narrow emission (FWHM of 25-30 nm) and high efficiency can be maintained, which would represent a real advance in both solution-processed OLEDs and LECs. This project will specifically develop solution-processable blue and red narrow band emitting TADF materials as these are both essential for displays and lighting and whose performance in current state-of-the-art OLEDs and LECs remains sub-optimal.

Keywords: organic light emitting diodes oleds,light emitting electrochemical cells lecs,thermally activated delayed fluorescence tadf,organic macro molecules,blue emitters,red emitters
Automatic detection of play behaviour in young pigs as a measure of positive affective states. (AutoPlayPig)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The welfare of animals kept for human consumption is of high concern globally, also within the European Commission including the welfare of the domesticated pig . As animal well-being is not just the absence of negative affective states, but also, and probably predominantly, the presence of positive affective states, identifying indicators of positive affective states in farmed animals can increase our capacity to improve their health and welfare. One such indicator is play behaviour. Play in pigs is an event occurring sporadically. Thus, using play behaviour for welfare assessment will not be possible through direct observations. Instead, it demands automation and continuous monitoring, two key elements of Precision Livestock Farming (PLF). The current project aims to investigate the relation between play behaviour in pigs and sensor data from image and sound analysis combining ethology and computer science into one field of Computational Ethology (CE). The project will focus on the CE part of the research, but the knowledge obtained could be used to develop real-time PLF algorithms for use in pig herds to observe the frequency and duration of play behaviour at pen level, beneficial to both the farmer, consultants, inspectors and future research projects within play behaviour in pigs. Training of the reseacher will include a thorough introduction to the field of CE and PLF, to the decoding and labeling of feature variables and to the use of machine learning algorithms on sensor data; all expertise fields of the hosting research group. All in all, the current project will take the first steps in developing a method for automatic recognition of play behaviour and positive affective states in pigs, as well as training the researcher for a future career within Computational Ethology and Precision Livestock Farming.

Keywords: computational ethology,precision livestock farming
Revolutionize the way humans interact with technology (RealHands)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 3106562.5
EU funding (EUR): 2174593.75
Participants: 1
Project status: CLOSED

Mobile Augmented Reality has the potential to go beyond gaming and transform the way we learn, work and interact. The main issue with mobile AR so far has been that a seemingly simple task, that is to create a real time understanding of how the hand moves by using only the already installed RGB camera and the processing power available in a mobile phone has been an unsolved technical problem. ManoMotion taps into this opportunity with its patented deep technology that integrates hand tracking and gesture analysis with Computer Vision, AI and Machine learning in a B2B solution that provides a framework for real- time 3D gestural analysis with the simple RGB camera found in everyday smartphones, with minimal computing power and minimal battery consumption. ManoMotion’s is the first software solution that creates realistic real-time hand understanding, gesture control & hand-to-object interaction in augmented reality and virtual reality environments. The company is on a mission to interpret human intent and make technology more natural and intuitive using one of the most versatile tools humans use to interact with the world: their hands. With the “RealHands” project, the company will push the development of the technology to be scalable and adaptable to a virtually endless range of applications: from videogaming to education to health applications. Goldman Sachs estimate that the total accessible market for AR software is 35 B$ in 2025 60% of which is driven by consumers. The largest segment, according to the same study, is projected to be the videogame market which is expected to generate 11.6 B$ from over 216M users in 2025, followed by health case sector at 5.1 B$ and engineering 4.7 B$. Thanks to this project ManoMotion will become a prime mover of this market.

Keywords: computer vision,augmented reality,mixed reality,virtual reality,mobile ar
A Whole New Category of Vehicle: The ONO Pedal Assisted Transporter (ONO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 2644723.75
EU funding (EUR): 1851306.0
Participants: 1
Project status: CLOSED

Worldwide, e-commerce is booming and parcel delivery and urban logistics have experienced rapid growth. And in light of the current Covid-19 virus pandemic, logistics operators are struggling to cope with the enormous increase in demand as people are confined to their homes, doing their part to slow the virus. This adds to the strain on operators’ already present challenges such as polluting vehicles, driver shortages, being stuck in traffic jams, and the lack of flexibility in routing and costs. Yet, delivery methods have hardly evolved in the last 90 years. The time is now to rethink and transform urban logistics. At ONO, we believed that there was a need for a vehicle that would bring about change in a positive and meaningful way. So, we created a whole new category of vehicle: the ONO Pedal Assisted Transporter (PAT). It’s a unique solution that is meant to improve city life quality by reducing road congestion and air pollution, all while being accessible to all genders. The ONO PAT combines the flexibility and advantages of a bicycle with the durability and cargo capacity of a van. The weather-protected electric vehicle features over 2100 litres of load volume capacity, integrated cargo loading ramps, an easy battery-swapping system, use of quality Tier-1 automotive components, and an aesthetically polished and distinctive design. Our vehicle also features the very unique selling point of having a modular platform base where one unit can be easily swapped for another module. The scope of this project includes optimising the ONO PAT, and its cargo-unit prototypes for a pre-series production, further developing the technology and software innovations, as well as optimising the business structure needed for commercialisation; preparing and setting-up for manufacturing; setting-up, testing and adjusting our service model ecosystem; testing our pre-series vehicles through fleet deployments; and conducting R&D for additional module-units and a solar roof.

Keywords: urban logistics,urban mobility,electric vehicle,cargo bicycle,modularity,smart mobility,future mobility
Fibroproliferative Invasive Fibroblasts in Idiopathic Pulmonary Fibrosis (FIBROSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2021-09-02
Duration (months): 36.0
Total project cost (EUR): 266063.4
EU funding (EUR): 266063.4
Participants: 2
Project status: CLOSED

Idiopathic Pulmonary Fibrosis (IPF) is a relentlessly progressive, lethal, lung disease with a uniquely poor prognosis. Patients typically die within 2-5years of diagnosis and IPF’s European incidence is increasing while effective therapies for improving survival remain elusive. IPF is a disease in which the normal wound healing responses are dysregulated leading to fibrosis and loss of gas-exchange regions in the lung rather than restoration of normal lung structure and function. Recently discovered invasive fibroblasts are believed to be central to the progressive fibrogenesis observed in IPF by contributing to an accumulation of fibroblasts in the injured lung and augmenting the destruction of normal alveolar structure. However the source of these invasive fibroblasts and what makes them so uniquely pathogenic is unknown. On this project I will work with Prof. Paul Noble, Cedars-Sinai Medical Centre, USA, one of the world’s leading IPF researchers and Ireland’s leading respiratory researcher Prof. Paul McLoughlin, University College Dublin, Ireland. The objectives of this project are to investigate: (1) the phenotype and behaviour of the invasive fibroblast from human IPF donors in vitro; (2) delineate the molecular pathways that make invasive human IPF fibroblasts uniquely pathogenic using state-of-the-art single cell RNA-sequencing; (3) determine the source of invasive fibroblast accumulation in the IPF lung using the most advanced lineage tracing methods available in a cutting-edge genetically modified mouse model. This interdisciplinary proposal will merge skills I have acquired with the latest technologies across multiple disciplines in world leading international institutions to explore the complex molecular basis of IPF. The results of this proposal will generate significant impact in the IPF field and will be directly applicable to the specific challenge highlighted in the H2020 Work Programme: Diagnostic characterisation of rare diseases.

Keywords: fibrosis,fibrotic diseases
“Intoxicated by turpentine”: An Olfactory History of Painting (1750-1939) (PaintOdor)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

“Intoxicated by turpentine.” When Marcel Duchamp so described the painters of his time, the avant-garde artist was not only criticizing a traditional way of thinking about the materiality of art, he was also modernizing a commonplace of medical discourse as well as a recurring and significant motif in the French commentary on the arts. Investigating historically the stereotype of “the smell of paint,” this research project seeks to underscore the important role of olfaction in the material history of art and in the historical conceptions of the art of painting in France from the mid-18th century to the first half of 20th. At the crossroads of art history and history of the sciences, this research will describe how medical concerns about the smell of paint significantly influenced the making and the composition of colors as well as the size and organization of the painter’s studio, consequently affecting the social status of the artist and, ultimately, the critical discourse on art, which often used the smell of a painting in metaphors expressing an aesthetical judgment. Thus, from the creation of a painting to its reception, the frequent references to the smell of paint unveil a hidden aspect of the history of art that will be illuminated through this analysis of a variety of historical sources, including, in particular, medical works, technical treatises on painting, industrial archives, art criticism, satirical drawings, etc. Finally, this historical research on the smell of a painting will be applied to the creation of a pedagogical tool aimed at the museum-going public. It will present the historical evolution of the painter’s studio through the smells of the painter’s materials. This sensory experience of the materiality of painting aims to embody art history, providing museum visitors with an alternative to the digital approach to works of art.

Keywords: sensory studies,smell studies,french studies,nineteenth century,history of painting,medical history,cultural history
Torque Vectoring Platform for Next Generation of Electric Driven Vehicles (TVP-eNext)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Slovenia
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of the TVP-eNext project is the development of a modular and scalable component solution for battery electric vehicles (BEV) and serial hybrid electric vehicles (HEV), which reduces both the cost and the complexity and increases the efficiency of the new generation electric drivetrains and simplifies the effective mechanical, thermal and electrical integration into the vehicle. The TVP-eNext project will deliver a unique Torque Vectoring hardware-software Platform (TVP) for torque vectoring system for vehicles with electric drivetrains with one electric motor per wheel. This type of new generation components enables software based torque distribution to individual wheels. It simplifies the implementation of the vehicle sub-systems, like Anti-lock Braking System, Traction Control System and Electronic Stability Program and enhances reliability, safety, stability and robustness of electric driven vehicles. Our TVP is compatible with any kind of BEV or serial HEV, such as with urban cars, common cars, sport cars, working vehicles, All-Terrain-Vehicles, trucks, buses, urban commercial vehicles and Heavy Duty Vehicles. We are addressing the trends and needs of the electric vehicle market. Considering the pitfalls of the existing solutions available to the commercial sector, we plan to address the market challenges of automotive component manufacturers, seeking to complement their product portfolio, as well as of the automotive manufacturers, where concrete interest in our solution already exists. The purpose of the SME Phase 1 TVP-eNext project is to outline the full scope of further development potential of our innovative solution, involving the technical and business viability issues, also regarding the analysis of the associated risks and the exploitation of the project commercial`s potential to the fullest.

Keywords: electronic stability program,traction control system,anti block system,electric drivetrain