Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IMMERSION COOLING OF SUSPENDED AND COATED NANO-PHOSPHOR PARTICLES FOR ENHANCED THERMAL AND OPTICAL EXTRACTION OF LIGHT EMITTING DIODES FOR GENERAL ILLUMINATION (NPLC-LED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-06-01
End date: 2016-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The introduction of high brightness light emitting diodes (LEDs) with white light and monochromatic colors has allowed LED penetration into general illumination applications. The increased electrical currents used to drive these LEDs have resulted in high heat fluxes, often exceeding those for average silicon computer chips. The output of a typical HB LED is today over 100 lumens, achieved with heat fluxes in excess of 300 W/cm2. Thermal management is, thus, a critical technology for LED lighting. Much of the current LED thermal research and development is focusing on air cooling with heat sinks. While these approaches provide significant heat removal capability, they are constrained by the presence of multiple interface resistances and they cannot effectively address non-uniform chip temperatures and local phosphor hot spots. To overcome the limitations imposed by air cooling, this research will investigate the potential of direct liquid cooling to provide an additional thermal path for heat dissipated in the LEDs and phosphor layers. The introduction of topside liquid cooling with optically-transparent liquids is expected to dramatically reduce average chip temperatures and to improve the uniformity of chip and phosphor temperature, leading to higher light extraction efficiencies.

Keywords: light emitting diodes,heat transfer,liquid cooling,leds
Mammalian Cell Surface Reorganization During Cell Division (MCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cell division is a fundamental process by which all living things propagate. The cell surface is the only part of the cell that communicates with its environment, and is thus of critical importance for tissue development, homeostasis and disease. Almost all aspects of the cell’s interior undergo dramatic reorganization by the entry into mitosis and these changes have been extensively studied. In contrast, very little is known about how the cell surface changes during cell division, though surface changes are likely to be important in metazoan tissues and cancers. To investigate the cell surface reorganization during cell division, I took advantage of the quantitative proteomics analysis of cell-cycle to evaluate the changes in the cell surface as cells progress through mitosis. The proposed research will focus on proteins that we identified in our proteomic analysis as strongly up regulated on the cell surface in mitosis. Because, i) such regulation is unprecedented, and its mechanism is unknown, ii) these are rare changes, suggesting a single unique mechanism, and iii) a cell-surface biomarker for mitotic arrest could be useful for improving anti-mitotic cancer chemotherapy. Investigation of mitosis dependent surface-exposed proteins will reveal novel biological regulation, for example how dividing cells loose adhesion and cell round up, and also how mitotic cells interact with the extracellular matrix and communicate with their neighbors in tissue. I identified two members of the protocadherin family that are enriched on the mammalian cell surface as cells move from interphase to mitosis. This proposal will examine the upstream cellular mechanisms that cause cell cycle dependent surface exposure as well as the downstream consequences at the cellular and tissue levels. Investigating the function and the molecular mechanism of protocadherin 1&7 proteins, which are largely unstudied, promise to shed new lights on cell division and cell migration.

Keywords: cell division,cell surface,protocadherin,cell-rounding,cell-adhesion,cell migration,quantitative proteomics,silac,cancer,biomarker
Flavor, Unification and Symmetries from Strings (FUSS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2015-08-31
Duration (months): 42.0
Total project cost (EUR): 87500.0
EU funding (EUR): 87500.0
Participants: 1
Project status: CLOSED

The proposed research program takes place in the context of High Energy Physics and, more precisely, in the subfield known as string phenomenology. The main goal is to develop the potential of string theory to produce realistic models of Particle Physics and Cosmology, as well as to understand the interplay between Quantum Gravity and the phenomenology of such models. The proposed line of research will be focused in analyzing the string theory models known as type II/F-theory vacua, with special emphasis in models where the gauge interactions of nature are unified (Grand Unified Theory models). It is expected to achieve significant developments in this area via analyzing the physics of these models, and in particular by understanding the flavor problem of Particle Physics in this context. In this sense, it is expected that Quantum Gravity will impose a specific structure of flavor in the above models, via the existence of discrete symmetries. The research program aims to unveil such structure and to classify those characteristic signatures that could be detected in current accelerator experiments. The program does not only involve the formation of researchers into the field of string phenomenology and model building, but it also intends to profit form the interdisciplinary synergy that is currently emerging in the field of string phenomenology, involving physicists that are both more phenomenologically and more mathematically oriented.

Keywords: physical sciences
Hybrid Quantum Electrical Circuits (HYBRIDQCIRCUITS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In this project, a variety of promising candidate systems for use as quantum bits (qubits) on future quantum electronic chips will be brought together and investigated in a truly quantum coherent manner. Static qubits made from superconducting electric circuits, and electrons trapped in islands on semiconductor chips will be coupled to ‘flying’ qubits in the form of quanta of light (photons) and quanta of vibrational motion (phonons) on electronic chips cooled to their lowest quantum mechanical energy state at close to absolute zero. The research will address key questions of how long the fragile quantum nature of information can last in such systems, how the different systems can be made to interact and exchange quantum information, and how they can be brought together to ultimately form the basic building blocks of future quantum computers, such as quantum logic gates and quantum memories.

Keywords: solid state physics,quantum technology
Channelfree liquid crystal microfluidics (FREEFLUID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovenia
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

FREEFLUID is a multidisciplinary research project aimed at a vibrant scientific field of complex soft matter, introducing microscopic flow threads and flow networks as programmable microscopic elements. We propose a novel approach –channelfree liquid crystal microfluidics- which combines the internal structure of the fluid with external stimuli to generate microscopic flow streams in a bulk fluid. With no channels, the approach generates flow which is directional, anisotropic, variably strong, and can be propelled with various external stimuli including electric, magnetic, and surface fields. The key advantages of channelfree microfluidics are its inherent programmability, reconfigurability, tunability, being moving-part-free, and the obvious no need for fabrication of channels and channel networks. The subtle backflow coupling of the flow to the orientational order of the fluid suggests strong potency for interesting applications, such as topological flow networks, hierarchically reconfigurable flow profiles, and flow assisted self-assembly of colloidal structures. The approach will be worked on by continuum mesoscopic modelling based on generalized liquid crystalline dynamics, combined with collaborative experiments. After the period of mobility, the wide outreach of the proposed research will lastingly integrate the researcher and offer him continuing professional development. The researcher will build upon his scientific excellence and train in scientific in non-scientific skills. FREEFLUID will be implemented at University of Ljubljana, renown in soft matter community for ingenuity and highest scientific standards. Integration of the researcher will transfer knowledge and create cohesion at bi-lateral and Community level. Strong ties with European and global scientific community, as well as general public, will put the researcher at the cutting edge of the ‘frontier research’ and create links to commercialise high-tech research results.

Keywords: flow,microfluidics,liquid crystals,channelfree,colloids,self-assembly,networks
Cancer Gene Discovery Using Somatic Gene Transfer in Mice (CGDM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cancer is the leading cause of death in the developed world. Significant emphasis has recently been placed on the characterization of the human cancer genome. However, the genetic complexity of cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumours. Forward genetic screens are powerful methods to identify genes involved in specific biological processes like cancer formation. However the difficulties and costs currently associated to such screens in vivo in mammalian systems are equally enormous. Here I propose the creation of a novel site-directed gene transfer system, allowing efficient and controlled somatic gene transfer in vivo in mice. This approach offers the possibility for the rapid creation of large number of somatic clones, over-expressing target proteins, or carrying transgenes to trigger RNAi response against the targeted gene products. I plan to screen cancer related miR-based gene knockdown libraries in this system, for the identification of novel genes involved in suppressing tumour formation. Recent findings are emphasizing the role of genomic instability caused by errors of DNA repair in the development of cancer. Using candidate gene approach I would like to investigate such mechanisms by the help of the proposed in vivo test system.

Keywords: transposon,recombinase mediated cassette exchange,somatic gene transfer,mouse genetics,dna repair,alkb,health sciences
A large-scale siRNA screen to study the role of kinases in Androgen Receptor activation (ARKSS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Prostate cancer is one of most commonly diagnosed cancer in European men and a leading cause of cancer-related death. If the cancer is diagnosed early, it is frequently curable by surgery or radiotherapy. However, locally advanced, recurrent or metastatic prostate cancer is much more difficult to control. These patients are commonly treated with androgen withdrawal therapy that is designed to inhibit the activation of the androgen receptor (AR). While initially successful, the effectiveness of this type of treatment is usually temporary and the surviving tumour cells almost always progress to a “castrate-resistant ” state. The treatment options for these patients are very limited and the median patient survival is 1-2 years. Despite this resistance, there is considerable evidence that the inappropriate activation of AR is linked to recurrent cancer growth. The AR therefore, remains the most effective therapeutic target to treat castrate-resistant prostate cancer. Phosphorylation of the AR by kinases has been demonstrated to induce transcriptional activation in low-androgen environments. This kinase-mediated pathway is believed to be one of the main causes of AR activation in castrate-resistant cancer patients. While various kinases have been identified to be involved in AR signaling, those tested only represent a small fraction of the total kinases present in the eukaryotic genome. Therefore, to better understand the role of kinases in AR activation, I am proposing to conduct a high-throughput siRNA screen against almost every kinase in the genome. This study will allow for the identification of those kinases that are critical for AR signaling. Importantly, this functional genomic screen will be conducted in multiple cell lines to give a deeper understanding of this heterogeneous disease. Given the importance of kinases of AR activation, the “hits” identified from this screen will offer novel drug targets for the treatment of prostate cancer.

Keywords: molecular biology,anticancer therapy,urology,biochemistry,oncology,molecular genetics,functional biology,pharmacological sciences,cell biology
A chemical approach to understanding the role of membranes and membrane transport in cell division (CHEMMEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cytokinesis, the final step of cell division, has two crucial processes to achieve: equal sorting of cellular components between the daughter cells, and membrane ingression and closure. Both processes strongly rely on membrane components and properties. It is known that some lipids localize to the cleavage site and that membrane transport is required to relieve cortical tension during cytokinesis, which is necessary for the physical separation of cells. However, the precise role and mechanism of this essential membrane retrieval are unknown, as is the nature of the lipids and proteins involved, in part because it has been difficult to study the role of lipids in membrane organization due to a lack of appropriate tools. The goal of this multi-disciplinary proposal is to understand which lipids participate in cytokinesis and how cytokinesis and membrane transport interface. I will combine approaches from chemistry and chemical biology with cell biology and imaging to achieve this goal. My comprehensive and systematic investigation will provide new insights into the important question of how cells divide, which will not only be important for basic biology, but also for understanding how cell division is mis-regulated in diseases such as cancer.

Keywords: chemical biology,small molecules,lipids,membrane transport,endocytosis,cytokinesis
School Opportunity Structure and Student Achievement in Comparative Perspective (SCHOOL OPP STRUCTURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-07-01
End date: 2016-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Most of the low achieving students are of low socioeconomic background. Low educational profile of their parents leaves these students in the educational system without any proper guidance. Scholars have emphasized the role of relations with peers and teachers in compensating for this negative background characteristic. Indeed, supportive and trusting relationships with peers, teachers and adults in school settings are essential to academic learning. However, little is known about the ways in which school opportunity structure shape these relationships. This project focuses primarily on two school types generating differing student achievements; Vocational High School (low student achievement) and General High School (relatively high school achievement) in Turkish educational system. In doing so, the proposed project aims at exploring in depth in what ways school opportunity structures in these two school types effect students’ school-based networks and their achievement.

Keywords: social sciences,school opportunity structure,school-based networks,school-based social capital,student achievement
Substrate specificity, mechanism and biological roles of rhomboid intramembrane proteases. (RHOMBOID SUBSTRATES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2013-03-01
End date: 2017-05-01
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Rhomboids are widely conserved intramembrane proteases. They are known to control important biological processes in model insect, worm, yeast and protozoan species, but their functions in most organisms including mammals and bacteria are unknown. The key to the understanding of rhomboid functions are their natural substrates, but it has been unclear how these are selected and recognized and methods for substrate identification have been lacking, which is limiting progress in the field. The core of this proposal aims to discover the biological roles of highly conserved rhomboids by identifying their natural substrates using a combination of advanced substrate specificity analysis, quantitative proteomics and genetics. I will initially focus on representative conserved bacterial rhomboids and identify their substrate repertoire using an in vitro biochemical screen. Subsequent biochemical and genetic analysis in vivo will reveal the biology of the substrates and rhomboids and indicate functions of their orthologues in pathogens. Enzymatic analysis of the identified substrates will elucidate rhomboid specificity and help us solve the three dimensional structure of a rhomboid substrate complex. In a complementary approach, I will use quantitative proteomics to identify substrate repertoire and elucidate substrate specificity of mammalian endoplasmic reticulum (ER) localised rhomboid RHBDL4, which will enable me to understand its biological role in ER-stress-induced cell death, indicated by preliminary experiments. This project will yield novel biological insights, provide a platform for rhomboid substrate discovery applicable to other biological contexts including pathogens, and provide a deep mechanistic and structural insight into rhomboid protease function, which will help us design new effective rhomboid inhibitors that are needed as experimental tools and have medical potential.

Keywords: natural sciences,intramembrane protease,bacteria,substrate specificity,proteomics,silac,endoplasmic reticulum
Ultrafast Dynamics, Energy Exchanges, and Non-linear Optical Properties of Resonant Nanostructures (UDENOP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

After a decade of existence, and driven by a remarkable expansion in research and development, plasmonics –the technology that exploit the unique optical properties of metallic nanostructures to enable routing and active manipulation of light at the nanoscale- has entered a defining period in which researchers will seek to answer a critical question: can plasmonics provide a viable technological platform which includes both passive and active nanodevices? The design of these devices is driven by a two-fold objective: 1) to manipulate electromagnetic energy at the nanoscale, including harvesting, guiding and transferring energy, with high lateral confinement down to a few tens of nanometers, and 2) to generate ultrafast and strong non-linear effects with low operating powers to produce basic active functions such as transistor or lasing actions. Utilizing the resonant properties –field enhancement and spectral sensitivity- of Surface Plasmons Polaritons (SPPs) is generally thought to represent a practical avenue to achieving this objective. In this context, this research aims to assess the potential for defects to enhance the non-linear optical properties of plasmonic crystals. The objective is to integrate defects, made of plasmonic cavities, in plasmonic crystals to create a focal point for electromagnetic energy stored in surface plasmon waves at the crystal’s interfaces. The role of the defect is then to transfer this energy to a neighbouring non-linear material in order to change its optical properties at the femtosecond timescale, thus creating an active functionality. This research, largely based on ultrafast time-resolved near-field optical microscopy, is also expected to enhance our understanding of ultrafast energy transfers at the nanoscale- a critical expertise in designing nanodevices.

Keywords: microscopy,metrology,surface physics,optical and dielectric properties