Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal (FLAMIN-GO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Italy,Slovenia,Switzerland,Switzerland,Türkiye,Latvia,France,United Kingdom,Portugal
Call: Next generation organ-on-chip (RIA-LS) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2025-06-30
Duration (months): 54.0
Total project cost (EUR): 6588942.2
EU funding (EUR): 5821613.75
Participants: 14
Project status: SIGNED

FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs. Conventional clinical trials may address part of these challenges, but are time consuming, expensive and ethically ethically doubtful as part of the patients still fail to achieve disease benefits. Thus, the rheumatology community has a need for an alternative strategy that can deliver innovative trials. FLAMIN-GO develops a personalized next-generation synovia-on-chip, that, by effectively mimicking the complexity of RA joint, will allow performing personalized clinical trials-on-chip. The solution will be based on design and fabrication of a multi-compartment microfluidic platform, for 3D culturing and perfusion of all the disease-relevant joint tissues. It focuses on synovia and synovial fluid, which are the pathogenetic targeted tissues, but including immune system, who sustain the disease, and cartilage and bone which are the end damaged tissues, leading to permanent disability. Starting from individual patient biopsies, this model seeks to replicate RA joints, thus allowing to test and allocate the best on-market drug for that patient in 1-2 months starting form biopsy. When validated, the platform will also be a turning point for i) pharma by enabling screening of new drugs reducing costs, time, and animal testing and for ii) translational research for identification of new biomarkers or therapeutic targets. FLAMIN-GO consortium features a strong, well-balanced composition of hospital, academia and industry partners, who cover with complementary expertise the whole value chain. It gathers experts in the fields of rheumatology, material science, tissue engineering, nanotechnology, cell biology and 3D modelling, in a cohesive, transdisciplinary, multi-sectorial approach taking on the challenge to drive RA personalized care.

Keywords: personalized medicine,clinical trial on chip,rheumatoid arthritis,recapitulation of arthritic joint,synovia on chip,microfluidic platform,3d bioprinting,plug and play module,mass fabrication
A new spectrophotometer for measurements in turbid liquids (Modu-Spectro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2022-08-31
Duration (months): 18.0
Total project cost (EUR): 200892.86
EU funding (EUR): 31250.0
Participants: 2
Project status: CLOSED

The ability to analyse compounds within turbid/scattering liquids is very important in fields related to Environmental monitoring, Medical analysis, Pharmaceutical testing and Food processing. However, for turbid liquids that include dirty water, blood, milk as well as unfiltered beer, wine, oils etc, unwanted multiple scattering effects occur, preventing any measurement or introducing large errors. Thus, current commercially available spectrophotometers are not capable of measuring within such liquids and time-consuming dilution procedures are required (when possible), ultimately modifying the properties of the probed liquid. In this proposal, we will explore the possibility of commercializing a new spectrophotometer where unwanted effects from multiple light scattering are efficiently suppressed. The instrument prototype used here is called Modu and is based on a new technology developed by the PI and his teams during the “Spray-Imaging” ERC-Starting Grant project. This technology is based on the use of a spatially modulated polychromatic light sheet (PCT pending) imaged from the side. This approach differs significantly from the transmission measurement commonly used in spectrophotometry. From some initial testing, it is found that the suggested technique provides fast, yet more accurate and reliable, characterization of turbid liquids, without the need for dilution. The proposed technology offers, then, a new solution to a variety of industrial problems including concentration measurements in turbid water and pharmaceuticals without any calibration; as well as assessing the colour and haze of unfiltered beverages such as beer, while keeping the sample intact. Thus, the technology and optical instrument proposed here is opening doors for a vast variety new measurement possibilities, including inline monitoring of turbid liquids.

Keywords: absorption spectroscopy,scattering,turbid media,concentration measurements in liquids
Renal Chloride Chanels and Blood Pressure Regulation (CLOPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Hypertension, or elevated arterial blood pressure, is a significant global health concern. A major cause of hypertension is the abnormality in salt (NaCl) handling in distal nephron segments within kidney. Although there has been long a debate with regard to the relative importance of Na+ vs. Cl- in inducing salt-sensitive hypertension, previous research demonstrated that excess intake of Cl- could lead to severe salt-sensitive hypertension. Thus, better understanding on molecular mechanisms of renal Cl- handling would provide useful insights in treatment of hypertension. Previous studies largely focused on the identification and regulation of apically expressed Cl- transporters, including Na+-Cl- cotransporter, Na+-K+-2Cl- cotransporter (NKCC1/NKCC2) and pendrin, but mechanisms and regulation of Cl- transporters on basolateral membranes (i.e. an exit of Cl- into the interstitial space) remains poorly described. Thus, the current proposal will investigate the physiological role of basolateral Cl- channel distributed in distal nephron, specifically ClC-kb. Using a transgenic ClC-kb knockout line of mice, I propose to investigate the physiological role of this channel within isolated tubule and at the whole animal level. In addition, ClC-kb channel is known to interact with a functional β-subunit, barttin, and this interaction could affect Cl- conductance. I propose to investigate the molecular mechanisms by which barttin can affect ClC-kb-mediated chloride transport. The proposed studies will shed new insights into the molecular mechanisms of Cl- reabsorption in distal nephron, and could provide a basis for novel approach in treatment of hypertension.

Keywords: hypertension,ion transport,chloride channels,sodium transport,kidney
Automated mass-manufacturing and quality assurance of Solid Oxide Fuel Cell stacks (qSOFC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Italy,Germany,Estonia,Sweden,Finland,Netherlands
Call: Development of cost effective manufacturing technologies for key components or fuel cell systems for industrial applications (H2020-JTI-FCH-2016-1, 2016)
Start date: 2017-02-01
End date: 2020-07-31
Duration (months): 42.0
Total project cost (EUR): 2110015.0
EU funding (EUR): 2110015.0
Participants: 8
Project status: CLOSED

qSOFC project combines leading European companies and research centres in stack manufacturing value-chain with two companies specialized in production automation and quality assurance to optimize the current stack manufacturing processes for mass production. Currently the state-of-the-art SOFC system capital expenditure (capex) is 7000…8000 €/kW of which stack is the single most expensive component. This proposal focuses on SOFC stack cost reduction and quality improvement by replacing manual labour in all key parts of the stack manufacturing process with automated manufacturing and quality control. This will lead to stack cost of 1000 €/kW and create a further cost reduction potential down to 500 €/kW at mass production (2000 MW/year). During the qSOFC project, key steps in cell and interconnect manufacturing and quality assurance will be optimized to enable mass-manufacturing. This will include development and validation of high-speed cell-manufacturing process, automated 3D machine vision inspection method to detect defects in cell manufacturing and automated leak-tightness detection of laser-welded/brazed interconnect-assemblies. The project is based on the products of its' industrial partners in stack-manufacturing value-chain (ElringKlinger, Elcogen AS, Elcogen Oy, Sandvik) and motivated by their interest to further ready their products into mass-manufacturing market. Two companies specialized in production automation and quality control (Müko, HaikuTech) provide their expertise to the project. The two research centres (VTT, ENEA) support these companies with their scientific background and validate the produced cells, interconnects and stacks. Effective exploitation and dissemination of resulting improved products, services, and know-how is a natural purpose of each partner and these actions are boosted by this project. This makes project results available also for other parties and increases competitiveness of the European fuel cell industry.

Keywords: sofc,fuel cell,manufacturing,quality control,quality assurance,interconnect
Computational Molecular Materials Discovery (CoMMaD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 1499390.0
EU funding (EUR): 1499390.0
Participants: 1
Project status: SIGNED

The objective of the project is to develop a computational approach to accelerate the discovery of molecular materials. These materials will include porous molecules, small organic molecules and macromolecular polymers, which have application as a result of either their porosity or optoelectronic properties. The applications that will be targeted include in molecular separations, sensing, (photo)catalysis and photovoltaics. To achieve my aims, I will screen libraries of building blocks through a combination of techniques including evolutionary algorithms and machine learning. Through the application of cheminformatics algorithms, I will target the most promising libraries, assess synthetic diversity and accessibility and analyse structure-property relationships. I will develop software that will predict the (macro)molecular structures and properties; the molecular property screening calculations will include void characterisation, binding energies, diffusion barriers, local assembly, charge transport and energy level assessment. A consideration of synthetic accessibility at every stage will be central to my approach, which will ensure the realisation of our predicted targets. I have several synthetic collaborators who can provide pathways to synthetic realisation. Improved materials in this field have the potential to either reduce our energy needs or provide renewable energy, helping the EU meet the targets of the 2030 Energy Strategy.

Keywords: computational chemistry,materials discovery,molecular materials
Galileo-EGNOS as an Asset for UTM Safety and Security (GAUSS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Italy,Greece,Netherlands,United Kingdom
Call: EGNSS Transport applications (H2020-GALILEO-GSA-2017-1, 2017)
Start date: 2018-03-01
End date: 2021-12-31
Duration (months): 46.0
Total project cost (EUR): 3695758.31
EU funding (EUR): 2972489.49
Participants: 9
Project status: CLOSED

The GAUSS project aims fast and thorough achievement of acceptable levels in terms of performance, safety and security for both, current RPAS and future UTM operations. UTM helps control, manage and integrate all RPAS in the VLL airspace to ensure the security and efficiency of UAS operations. The key element within GAUSS is the integration and exploitation of Galileo-EGNOS exceptional features for precise and secure positioning. These features will enable not only safe, timely and efficient operations but also coordination among a higher number of RPAS with appropriate levels of security, as it provides anti-jamming and anti-spoofing capabilities. Multi-frequency and multi-constellation solutions will be exploited with this purpose. GAUSS will increase resilience in UTM operations and, at the same time, ensure UTM coordination capabilities to increase the number of platforms that can share the same airspace. Precise coordination among UAS in the air, together with individual high precision and secure positioning are key for the safety of the operations and therefore for the success of UTM. The UTM infrastructure will also benefit from the GAUSS Galileo-EGNOS based ADS-B solution and encrypted air-ground communications. GAUSS includes the definition, negotiation and execution of safe trajectories both in normal operation and in case security or safety is compromised. The GAUSS systems will be validated with two field trials (in-land and sea) with the operation of 4 UTM coordinated RPAS with different types (fixed and rotary wing) and EASA operational categories. The outcome of the project will consist of Galileo-EGNOS based technological solutions to enhance safety and security levels in current RPAS operations and future UTM based operations. Increased levels of efficiency, reliability, safety and security in RPAS operations are key enabling features to foster the European RPAS regulation and market development and their full acceptance by the European society.

Keywords: rpas,unmanned aerial vehicle,remotely piloted aerial system,uas traffic management,multi frequency,multi constellation,navigation performance,security,safety,coordination
AUTONOMOUS DECISION MAKING IN VERY LONG TRAVERSES (ADE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Austria,Germany,Spain,Belgium,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: SRC – Space robotics technologies (H2020-SPACE-2018, 2018)
Start date: 2019-02-01
End date: 2021-04-30
Duration (months): 27.0
Total project cost (EUR): 3000001.25
EU funding (EUR): 3000000.0
Participants: 16
Project status: CLOSED

ADE (Autonomous DEcision making) objective is develop and test in a representative analogue a rover system suitable to increase data collection, perform autonomous long traverse surface exploration, guarantee fast reaction, mission reliability, and optimal exploitation of resources. ADE specific objectives (WP full coverage): - Autonomous long range navigation with high reliability. The ADE rover guidance receives a goal location. It is in charge of planning and executing a safe and efficient route to this goal. It locally re-plan to visit new local goals, enabling the ADE to seize scientific opportunities. - Consistent data detection / avoiding un-detection of interesting data. Interesting environmental features will be detected by the Opportunistic Science agents. ADE includes two instruments that will generate observation conflicts to be solved by ADAM. - Autonomous decision making capabilities (E4) in presence of conflicts. Key components of ADE is ADAM, Autonomous decision making Module. It is based on the tight integration/update of robotic technologies including the outputs of OG1-OG4. It will autonomously and safely modify the rover nominal plan in case of identification of interesting feature /environmental hazards in compliance with system constraints, on-board resources and temporal restrictions. - Demonstration in a representative environment. ADE will be tested in incremental manner till full representative analogue. Its components, ADAM and the ADE avionic, represent a step ahead in technologies applicable to multiple scenarios. The ADE demonstrator represents a breakthrough wrt the way rovers will explore unknown hostile environments, both in space and on Earth. OG10 will maintain OG2. - Dissemination/communication & Exploitation. Dedicated Plans are elaborated inc. direct consultation with stakeholders. - Collaboration/harmonization with other Call 2 OGs teams. Through the I/F Engineer. The ADE team is open to share developments in common element

Keywords: autonomous decision making,long range navigation,opportunistic science,localization and mapping,exploration missions,analogue environment,ground control system,terrestrial applications,rover
Money, Rituality and Tombs in northern Italy during Late antiquity (MORTI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Placing coins as grave offerings was one of the most common, and is among the most widely studied, funerary pagan practices in the Roman world. Charon’s obol was the toll that souls had to pay to be ferried to the netherworld. The deposition of coins in tombs did not cease with the Christianisation of the Roman world, and the extension, prevalence (in terms of geographical areas, types of burial, etc.) and meaning of this practice during the Middle Ages are unclear. The main aim of MORTI is to interpret the use and meaning of coinage in post-classical funerary practices through its full archaeological contextualisation and the study of its relationship with the personal traits of the individuals they were buried with (sex, age, social and religious affiliation, etc.). Northern Italy is an ideal region where to carry out this project; it is no only a key region to understand the transformations undergone by the Mediterranean world after the fall of the Roman Empire (militarisation of society and settlements, Gothic and Lombard kingdoms, the struggle between Arrians and Catholics, commercial exchange, etc.); it has also been subject to specific studies about post-classical funerary practices (CAMIS, CARE) leading to over 15,000 data entries that are of interest for the project. MORTI will use this record and statistical multivariate correspondence methods to analyse circa 800 coins from over 120 necropolis dated to between the 3rd and 11th centuries. This analysis will specifically examine the phenomenon of Charon’s obol, and more broadly the characteristics of funerary ritual and the evolution of post-classical mentalities over time. MORTI will create new links between numismatics and funerary archaeology, as well as opening a wide array of research and professional avenues to the applicant.

Keywords: coin in context,ritual use of coinage,funerary archaeology,evolution of mentalities,statiscal correspondence analysis,late antiquity,early middle ages
No Dollar Too Dark: Free Trade, Piracy, Privateering, and Illegal Slave Trading in the Northeastern Caribbean, early 19th Century (NDTD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-07
End date: 2024-02-06
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The multidisciplinary project ‘No dollar too dark: free trade, piracy, privateering and illegal slave trading in the northeast Caribbean, early 19th century’ (NDTD) integrates maritime archaeology, history, geophysical survey and anthropology to investigate illicit trade between the Caribbean islands St. Eustatius, Saba, St. Thomas, St. Bartholomew and St. Maarten (5S) from 1816 to c.1840 with the aim of understanding why and how these islands were drawn into an illicit trade network, what archaeological evidence remains of these activities and why this is relevant to current ‘theories of piracy’ and modern illicit trade in the region. NDTD has five Research Objectives (RO) to investigate: RO1) Entanglements between international, regional and local factors that drove these islands to engage in illicit trade. RO2) How these islands functioned together as a network for illicit trade, smuggling and laundering, the processes involved, and how long it occurred. RO3) Dialectics between the acquisition of illicit goods, consumption of these goods, and race, class, and gender . RO4) Archaeological evidence of these activities. RO5) How illicit trade from this period informs the ‘theories of piracy’ proposed by scholars in the 21st century

Keywords: illicit trade,piracy,maritime archaeology,maritime trade,material culture,consumption