Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mapping Immigrant Imaginations: Comparing North Africans in Montréal and Marseille (Im.magine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 244385.28
EU funding (EUR): 244385.28
Participants: 2
Project status: SIGNED

Migration scholars are increasingly attentive to human agency in global mobility processes, leading to a growing interest in ‘migratory imaginations’. There is an unfortunate tendency in the discipline, however, to emphasise the perceptual dimension of the imagination at the expense of its action-oriented one. This hinders the imagination's conceptual and empirical potentials, not least where the particularly ‘active’ imaginations of immigrants are concerned. We know, for instance, that migrants are likely to develop multiple place affiliations and cultural identifications by virtue of their exposure to several environments. Yet little is known about the sociocognitive frameworks that foster these multipolar orientations. Im.magine addresses this gap by treating international migration experience as an ‘extreme life event’ that expands the imagination through combined material and symbolic processes. On a theoretical level, Im.magine underscores the crucial elements of relational and reflexive thinking, which are visible in foundational sociological and geographical conceptions of the imagination, yet frequently overlooked in research on migration-related imaginations. It offers an empirical application of reflexive imaginations by means of comparative case studies of North Africans living in Montréal, Canada, and Marseille, France. Through a triangulated use of official and literary discourse as well as first-person oral, visual, sensory, and digital migration narratives, it will help open up the ‘black box’ of immigrant imaginations. Specifically, by casting migrant biographies onto multiscalar and inter-connected spatio-temporal frames, the project will advance our understanding of complex place affiliations and identifications, thus illuminating the very real impacts of the imagination on mobility processes.

Keywords: geographic imaginations,reflexive and cognitive approaches to migration,mental mapping,migration narratives
BIOMIMETIC FIXATION OF CO2 AS SOURCE OF SALTS AND GLUCOSE (CO2LIFE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1302710.0
EU funding (EUR): 1302710.0
Participants: 1
Project status: SIGNED

The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates. The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry, thus, new CO2 emissions are avoided and the carbon cycle is closed. This project will provide a technological solution at industrial scale for the removal and reutilization of CO2.

Keywords: co2 capture,membrane technology,enzymatic conversion
Glyco-Nanoparticles for Applications in Advance Nanomedicine (NanoCarb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Spain,Italy,Germany,Spain,Ireland,Belgium,Belgium,Switzerland,Sweden,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-01
End date: 2023-03-31
Duration (months): 54.0
Total project cost (EUR): 4075132.26
EU funding (EUR): 4075132.2600000002
Participants: 16
Project status: SIGNED

The advance of nanomedicine requires the development of novel materials with tailored properties, controlled circulation, optimal targeting and therapeutic efficacy after administration. Nanomaterials engineered with glycans offer multiple possibilities for nanomedicine as these biomolecules when arranged on a nanomaterial surface display strong binding to specific receptors while at the same time the glyco coating can restrict unspecific interactions with proteins, helping to avoid the mononuclear phagocyte system and improved biocompatibility in vivo. The NanoCarb Network will develop novel and well-characterised nanomaterials with synthetic and native N-glycans that will be used for therapeutics and guide development of new drug delivery applications. The project will train early stage researchers at the interface of nanotechnology and glycosciences, with the overall goal of achieving a new generation of professionals in nanomedicine for a prospective career in both academia and industry. To achieve this goal a multidisciplinary consortium has been created including universities, research centres and SMEs with broad expertise ranging from nanotechnology, carbohydrate chemistry, glycoprofiling and in vitro – in vivo screening specialists. An ambitious training plan will be implemented including courses, outreach activities, participation in seminar, and workshops for the development of scientific and transferable skills.

Keywords: bionano interactions,corona,sugars,glycans,carbohydrates
Hybrid Human-AI Regulation: Supporting Young Learners' Self-Regulated Learning (HHAIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499248.0
EU funding (EUR): 1499248.0
Participants: 1
Project status: SIGNED

Hybrid systems combining artificial and human intelligence hold great promise for training human skills. I propose to develop Hybrid Human-AI Regulation (HHAIR) to develop learners’ Self-Regulated Learning (SRL) skills within Adaptive Learning Technologies (ALTs). HHAIR targets young learners (10-14 years) for whom SRL skills are critical in today’s society. Many of these learners use ALTs to learn mathematics and languages every day in school. ALTs optimize learning based on learners’ performance data but even the most sophisticated ALTs fail to support SRL. In fact, most ALTs take over (offload) control and monitoring from learners. HHAIR on the other hand aims to gradually transfer regulation of learning from AI-regulation to self-regulation. Learners will increasingly regulate their own learning progressing through different degrees of hybrid regulation. In this way HHAIR supports optimized learning and transfer (deep learning) and development of SRL skills for lifelong learning (future learning). This project is ground-breaking in developing the first hybrid systems to train human SRL skills with AI. The design of HHAIR resolves four scientific challenges: i) identify individual learner’s SRL during learning; ii) design degrees of hybrid regulation; iii) confirm effects of HHAIR on deep learning; and iv) validate effects of HHAIR on SRL skills for future learning. The four design challenges are addressed by investigating ALTs’ trace data in exploratory studies (WP1), applying these insights to develop HHAIR in design studies (WP2), investigating immediate effects on deep learning in short-term field studies (WP3) and effects on SRL-skills for future learning in long-term field studies (WP4). The AI@EDU infrastructure will connect HHAIR to ALTs used daily in schools across Europe. The project will develop advanced measurement of SRL and algorithms to drive hybrid regulation for developing SRL skills in ALTs.

Keywords: self regulated learning,adaptive learning technologies,artificial intelligence,hybrid systems,learning analytics,dashboards
Dissecting the role of sex hormones in human antiviral immunity (SHIFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

COVID-19 severity and mortality are consistently higher in men than women. Still, the mechanisms that underlie sex differences in human antiviral immunity remain poorly understood. Therefore, investigating sex-specific regulation of immune responses is a critical step for developing novel and effective antiviral therapies. The overarching goal of SHIFT is to dissect the precise contribution of sex hormones to human antiviral immune function by studying the immune system of individuals as they undergo sex-reassignment therapy with sex hormones. The three specific aims proposed are 1) to evaluate the sex hormone contribution to viral infection susceptibility, 2) to characterize sex hormone effects on the immune-microbe interactions and balance, and 3) to assess sex hormone effects in antiviral immune responses during infection. SHIFT will combine the experienced researcher’s advanced knowledge in sex hormone regulation of immune function and metabolism, with the host lab’s state-of-the-art multi-omics technologies, advanced expertise in systems immunology analysis and established collaborations in Sweden. Aims will be achieved during a planned 24-month training at Karolinska Institutet that involve technical training (sample collection and processing), analytical training (integrative computational analysis and statistics), and development of transferrable skills (project management, mentoring, leadership and communication). The two-way transfer of knowledge in SHIFT will lead to implementation of new techniques, mentoring of trainees, and identification of sex-hormone regulated pathways in antiviral immunity that will be valuable for vaccine design, antiviral therapies and immunomodulatory therapies at large. Further, the MSCA fellowship will provide a strong training path in systems immunology to lead the fellow towards academic independence in the EU and support her career goals of becoming an investigator studying immunological basis of disease susceptibility.

Keywords: immunology,human immunity,immune function,sex differences,sex hormones,systems immunology,viral infection,antiviral immunity,antiviral immune responses
Smart Wound monitoring Restorative Dressings (SWORD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,Romania,Slovakia,Czechia,Brazil,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 423200.0
EU funding (EUR): 303600.0
Participants: 7
Project status: SIGNED

The project aims to combine the expertise and resources of four academic groups working at the frontiers of material research and two SMEs, one engaged in producing commercial medical materials as well as having own research capacities. The Consortium plans to develop wound dressings which an be rated as a radical innovation in the area of chronic wound care. Our efforts will concentrate on the design of a new product which will combine diagnostic and therapeutic actions and facilitate wound healing, while at the same time minimize treatment costs and optimize wound management thus positively influencing patient's wellbeing. A range of new composites derived from naturally occurring materials, such as chitin and halloysite combined with colloids will be studied. The ensuing hybrid materials will be processed using micro- and nano-manipulating tools, including roll-to-roll and electrospinning technologies. A thorough characterization program will be undertaken in order to understand the molecular-level interactions between the composite components. The determination of materials structure will allow a complete understanding of how their properties originate so that they can be tailored to precisely fit their application. The dressing will feature diagnostic sensors capable of measuring pH, humidity, temperature and associated bacterial activity as well as a highly absorbent layer designed to drain the wound and release therapeutic agents. Each member of the Consortium is well-resourced in terms of facilities, infrastructure and technology transfer support so as to provide an ideal environment for the research program, the training of younger researchers and the exploitation of findings. Leveraging from nationally funded grants and actively engaging in research exchanges while seeking to produce a radical innovation in the area of 'smart' dressings the project will address all three key drivers of the knowledge-based society, namely research, education an innovation.

Keywords: chitosan,hybrid nanostructures,langmuir blodgett films,smart dressings
Virtual experimental toolbox for 3D/4D recrystallization (VETRex4D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Although microstructural characterization techniques are advancing, they are still inadequate to explain the complex behavior of recrystallization: Unexpected local grain boundary migration may relate to local variations in the deformation microstructure, but 3D quantification is needed. Newer studies suggest that residual stress may affect the boundary migration, but consensus is lacking. Additive manufacturing is becoming popular. Here the formation of pores/voids are observed but their effect on boundary migration is totally unexplored. Various processes and materials parameters are coupled and acting simultaneously, their individual effects cannot be separated experimentally. A novel paradigm is required to quantify the above-mentioned new and critical aspects with the larger longer-term goal to improve properties and design novel materials. I want to show that a virtual experimental toolbox for 3D/4D recrystallization is the way forward to remove the bottleneck. In this toolbox, for the first time ever, quantitative phase-field simulations will be directly coupled with 4D X-ray Microscopy (4DXRM) experimental data. The necessary steps to achieve my goals: 1) Develop expertise in 4DXRM and learn to design the critical experimental studies (supervisor is expert). 2) Develop quantitative 3D phase-field models to capture complex behavior of recrystallization and implementation it in MOOSE Framework software for large-scale simulations (PI is expert) 3) Coupling of 4DXRM data with MOOSE Framework (in collaboration). The vision is that the newly developed virtual experimental toolbox can be used by experimentalists and scientists in industry with minimal training. This fellowship is going to make me a unique expert in the field of phase-field model development and experienced in 4DXRM characterization, which will make me employable at leading European research institutions.

Keywords: phase field modeling,recrystallization,grain boundary migration,4dxrm,3d printed metals,large scale simulations
Measuring the open to closed beauty ratio in heavy-ion collisions at LHC (CMSHInBeauty)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The goal of this proposal is to understand the behaviour of bottomonia, i.e., bound states of bottom quark pairs, in heavy-ion collisions. The dissociation of these states is directly linked to the temperature of the quark-gluon plasma (QGP) formed in these collisions. However, additional effects not related to the QGP formation, referred to as cold nuclear matter effects, are also thought to play a role, complicating the interpretation of present data. A new quantity is proposed to disentangle these effects and isolate the dissociation effect of the QGP: the ratio of the nuclear modification factors (a normalized comparison of heavy-ion and proton-proton collisions) of bottomonia and open beauty. This quantity is particularly powerful if measured over the entire cross section, down to low transverse momentum. The open beauty measurement, carried out via non-prompt J/psi identification, is challenging at low transverse momentum and the project will start by a technical development aiming at reaching transverse momentum = 0 GeV/c in the heavy-ion environment. The measurements of bottomonia and open beauty will then be carried out with the high luminosity data at increased centre-of-mass energy that will be provided by LHC at the end of 2015. The final piece of the bottomonia puzzle is the measurement of the Xb excited states, which have never been measured in heavy-ion collisions, but which give a significant feed-down contribution to the Y(1S) ground state. A feasibility study of this difficult measurement will conclude this proposal.

Keywords: bottomonia,non prompt j,psi,heavy ion collisions,nuclear modification factor
Bacterial cooperation at the individual cell level (BactInd)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1994981.0
EU funding (EUR): 1994981.0
Participants: 1
Project status: CLOSED

All levels of life entail cooperation and conflict. Genes cooperate to build up a functional genome, which can yet be undermined by selfish genetic elements. Humans and animals cooperate to build up societies, which can yet be subverted by cheats. There is a long-standing interest among biologists to comprehend the tug-of-war between cooperation and conflict. Recently, research on bacteria was successful in identifying key factors that can tip the balance in favour or against cooperation. Bacteria cooperate through the formation of protective biofilms, cell-to-cell communication, and the secretion of shareable public goods. However, the advantage of bacteria being fast replicating units, easily cultivatable in high numbers, is also their disadvantage: they are small and imperceptible, such that measures of cooperation typically rely on averaged responses across millions of cells. Thus, we still know very little about bacterial cooperation at the biological relevant scale: the individual cell level. Here, I present research using the secretion of public goods in the opportunistic human pathogen Pseudomonas aeruginosa, to tackle this issue. I will explore new dimensions of bacterial cooperation by asking whether bacteria engage in collective-decision making to find optimal group-level solutions; whether bacteria show division of labour to split up work efficiently; and whether bacteria can distinguish between trustworthy and cheating partners. The proposed research will make two significant contributions. First, it will reveal whether bacteria engage in complex forms of cooperation (collective decision-making, division of labour, partner recognition), which have traditionally been associated with higher organisms. Second, it will provide insights into the evolutionary stability of cooperation – key knowledge for designing therapies that interfere with virulence-inducing public goods in infections, and the design of stable public-good based remediation processes.

Keywords: bacterial cooperation,division of labour,collective decision making,cell to cell interactions