Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New Particle Formation in Polluted Atmospheres by Nanocluster Dynamics Assessment (NPF-PANDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-09-03
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

NPF-PANDA aims for a multi-method assessment of cluster dynamics in urban environments during new particle formation. New particle formation by gas-to-particle conversion is frequently detected in the atmosphere, but, according to the current understanding, should not proceed in heavily polluted urban areas, where large amounts of primary aerosol particles are present acting as sink for both condensable vapours and newly formed clusters. However, it is nonetheless observed in Chinese megacities where it even can promote haze formation and hence impact urban air quality. It is under debate, whether this is linked to faster cluster growth or a less effective condensation sink than commonly assumed. NPF-PANDA will quantify urban cluster size-distributions below 3 nm with a multi-instrument approach and novel data analysis methods. This will lead to unprecedented high quality data of the cluster dynamics and solve the role of fast growth on the survival probability of newly formed clusters under high condensation sink. By combining measurements from urban Beijing with precisely tailored laboratory experiments at the CERN CLOUD chamber, the magnitude of the underlying microphysical growth processes like coagulation or condensation will be disentangled and the effects of different precursor gases can be tested. Cluster dynamics simulations will back-up the experimental findings and via a detailed comparison of measured and simulated size-distributions, this will reveal information on cluster stability and the cluster-stabilizing role of different bases. Altogether, the project will be an essential part in solving the “China-NPF-puzzle” and hence impact future air quality research and air pollution mitigation, which is also highly relevant for medium-polluted European cities.

Keywords: aerosol dynamics,new particle formation,air pollution,cluster growth,megacity environments
The impact of highly magnetic neutron stars in the explosive and transient Universe (MAGNESIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-11-30
Duration (months): 78.0
Total project cost (EUR): 2263148.0
EU funding (EUR): 2263148.0
Participants: 1
Project status: SIGNED

The gravitational wave window is now open. It is then imperative to build quantitative models of neutron stars that use all the available tracers to constrain fundamental physics at the highest densities and magnetic fields. The most magnetic neutron stars, the magnetars, have been recently suggested to be powering a large variety of explosive and transient events. The enormous rotational power at birth, and the magnetic energy they can release via large flares, put the magnetars in the (yet) hand-wavy interpretations of gamma-ray bursts, the early phases of double neutron star mergers, super-luminous supernovae, hypernovae, fast radio bursts, and ultra-luminous X-ray sources. However, despite knowing about 30 magnetars, we are lacking a census of how many we expect within the pulsar population, nor we have robust constraints on their flaring rates. The recent discovery of transient magnetars, of magnetar-like flares from sources with measured low dipolar magnetic fields and from typical radio pulsars, clearly showed that the magnetar census in our Galaxy is largely under-estimated. This hampers our understanding not only of the pulsar and magnetar populations, but also of them as possibly related to many of Universe’s explosive events. MAGNESIA will infer a sound Magnetar Census via an innovative approach that will build the first Pulsar Population Synthesis model able to cope with constraints/limits from multi-band observations, and taking into account 3D magnetic field evolution models and flaring rates for neutron stars. Combining expertise in multi-band observations, numerical modeling, nuclear physics, and computation, MAGNESIA will solve the physics, the observational systematic errors, and the computational challenges that inhibited previous works, to finally constrain the spin period and magnetic field distribution at birth of the neutron star population.
Development of a new and highly efficient micro-scale CHP system based on fuel-flexible gasification and a SOFC (FlexiFuel-SOFC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Austria,Netherlands,Netherlands,Netherlands
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2014-1, 2014)
Start date: 2015-05-01
End date: 2019-06-30
Duration (months): 50.0
Total project cost (EUR): 5988163.75
EU funding (EUR): 5982101.25
Participants: 10
Project status: CLOSED

The project aims at the development of a new innovative highly efficient and fuel flexible micro-scale biomass CHP technology consisting of a small-scale fixed-bed updraft gasifier, a compact gas cleaning system and a solid oxide fuel cell (SOFC). The technology shall be developed for a capacity range of 25 to 150 kW (fuel power) and shall be characterised by a wide fuel spectrum applicable (wood pellets and wood chips of various sizes and moisture contents, SCR, selected agricultural fuels), high gross electric (40%) and overall (85-90%) efficiencies as well as almost zero gaseous and PM emissions. This aim shall be reached by the combination of a fuel-flexible updraft gasification technology with ultra-low particulate matter and condensed alkaline compound concentrations in the product gas, which reduces the efforts for gas cleaning, an integrated gas cleaning approach for dust and HCl removal, desulphurisation and tar cracking as well as a SOFC system which tolerates certain amounts of tars as fuel. It is expected to achieve at the end of the project a TRL of 5. The objectives of the project are highly relevant to the work programme since they focus on the development of a micro-scale CHP technology with extended fuel flexibility which shall be cost efficient and robust and shall distinguish itself by high electric and overall efficiencies as well as almost zero emissions. To fulfil these goals an overall methodology shall be applied which is divided into a technology development part (based on process simulations, computer aided design of the single units and the overall system, test plant construction, performance and evaluation of test runs, risk and safety analysis) as well as a technology assessment part covering risk, techno-economic, environmental and overall impact assessments, market studies regarding the possible potentials for application of the new technology as well as dissemination activities.

Keywords: biomass,sofc,fuel flexibility
Seismic-resistant Highly Deformable Structures (SHDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The recent earthquakes that have struck Europe the last decade, L’Aquila (2009) and Lorca (2011) have shown that even for a moderate seismic hazard level the seismic action can cause huge personal and economic losses. Therefore there is a need for new structural designs based on the performance of the structures during earthquakes rather than their strength. This project will focus on the development and verification of a novel seismic-resistant highly deformable reinforced concrete structure. This innovative design takes advantage of the superior deformability of reinforced High Deformability Concrete (HDC) elements to develop a structure with controlled performance, in which the structural damage is concentrated in especially designed elements. The new structural system combines ductile shear walls with flexible coupling beams designed with reinforced HDC. HDC is currently being developed by the host Institution as part of Anagennisi, a FP7 EU funded project, and utilises recycled rubber particles as replacement of both fines and coarse aggregates. A preliminary experimental investigation is being undertaken to characterise the mechanical properties of HDC, and complimentary testing is planned to be carried out as part of this fellowship. This initial multi-scale testing phase will be followed by the development of a material model and its implementation in a finite element software for the analysis and assessment of representative prototypes of seismic resistant highly deformable structures. The new structure will be more sustainable as it will be easily repairable after an earthquake and will have a better seismic performance avoiding non-structural damages. This project will contribute to the development of new technology in Europe, and will provide an important stepping stone for the fellow’s career.

Keywords: fiber reinforced polymers,rubberised concrete,performance based seismic design
Mechanisms of stress-induced cognitive deficits : Role of the glucocorticoid receptor and its partners in the regulation of PFC function. (StressPFCog)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-04
End date: 2020-01-03
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The prefrontal cortex (PFC) is a locus for higher-order cognition and executive control across species. In most mental disorders such as depression or schizophrenia, dysfunction in PFC and its related neuronal networks has been associated with a variety of cognitive impairments. Chronic stress exposure and abnormal levels of glucocorticoid stress hormone (GCs) is a key environmental risk factor for psychiatric illness. The PFC is highly vulnerable to stress exposure and many studies have reported detrimental effects of chronic stress exposure and/or high GCs levels on cognition, however the physiological underpinnings remain poorly understood. GCs exert their action in part by binding the glucocorticoid receptor (GR), a transcription factor expressed in every cell type. Through a complex interplay with co-factors, GR can modulate the expression of a large set of genes and thereby modify brain circuit physiology ultimately leading to behavioural changes. In this project, I propose to investigate the molecular and cellular mechanisms through which stress-exposure can modify the activity of PFC and its related networks and lead to cognitive impairment. Combining viral-mediated gene transfer and conditional mutagenesis in mice, I propose to inactivate GR either within the whole PFC or in discrete PFC cell populations namely the pyramidal neurons or the parvalbumin-expressing interneurons. I will study the impact of these manipulations on cognitive function including working memory and behavioural flexibility under basal conditions or after chronic stress exposure. The physiological correlates of cognitive deficits will be investigated using multisite electrophysiology recordings in behaving mice with a specific focus on PFC-hippocampus-midbrain circuits. Finally, I propose to examine the PFC-specific role of an important GR binding partner called BRG1, a chromatin remodeler recently linked to cognitive decline in several psychiatric conditions.

Keywords: stress,cognition,prefrontal cortex,glucocorticoid receptor,chromatin remodeller
Efficient Material Hybridization by Unconventional Layup and Forming of Metals and Composites for Fabrication of Multifunctional Structures (LAY2FORM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Germany,Spain,Spain,Belgium,France,France,Portugal
Call: Integration of unconventional technologies for multi-material processing into manufacturing systems (H2020-FOF-2017, 2017)
Start date: 2017-10-01
End date: 2022-03-31
Duration (months): 54.0
Total project cost (EUR): 4931303.75
EU funding (EUR): 4931294.75
Participants: 16
Project status: CLOSED

LAY2FORM will create a new cost-effective multistage manufacturing platform based on flexible machinery concepts, cognitive automation, inline monitoring and inspection, as well as simulation and modelling, enabling the efficient integration of unconventional technologies (laser and ultrasound) in established composites-based processes, namely tape-laying and hot-forming, to enable the production of multifunctional 3D hybrid parts from thin layered metals and thermoplastic-matrix composites. Framed by an end-to-end engineering approach, LAY2FORM will shorten the design and manufacturing cycle time and improve reliability, presenting a substantial potential to, in the middle term, turn the manufacturing of complex and intricate hybrid composite-metal parts highly cost competitive. The enhanced LAY2FORM manufacturing system will be a system of systems, containing the enabling process modules and digital sub-systems to create a continuous and automated manufacturing chain. Moreover, LAY2FORM will apply an integrated and systemic approach to implement full manufacturing routes and create new value chains, from materials conditioning to materials disassembly, being a robust basis for the efficient production of hybrid lightweight structures. The multidisciplinary approach proposed in LAY2FORM comprises a complex interconnection of leading R&I topics to develop an industrially-feasible and competitive manufacturing platform, compatible with the Industry 4.0 vision.

Keywords: material hybridization,composites,thermoplastics,metals,laser processing,us assisted processing,hot forming,lay up,cognitive automation,end to end engineering,sustainable manufacturing
Bio-inspired Protection of Marble with Lasers (BioProMarL)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain,Spain
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 100667.84
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Marble is a widely used raw material in the kitchen/bathroom market, as well as in the construction sector. Yet, its durability is harmed by atmospheric and local acidic conditions and its aesthetic appearance endangered by human pollution and contamination. Although surface sealing is frequently used for protection, sealers are often toxic and not sufficiently effective. Long-term conservation or replacement of marble generates enormous costs. BioProMarLL aims at transferring the surface protective properties of certain plants to the marble surface, employing biomimetic laser structuring strategies that have been developed during the recently finished FET-Open project LiNaBioFluid. The overall objective of BioProMarL is the development of breakthrough concepts inspired by nature to provide enhanced protection of the marble surface in indoor and outdoor applications in terms of resistance to human pollution (e.g. stains by oil, lemon, vinegar, …). Additional functionalities that will be intended to transfer to marble include liquid-repellence, anti-adhesion and anti-abrasion, further strengthening the complementarity with LiNaBioFluid. The project consortium already includes a marble product company as end user and aims at identifying other end users for the different functionalities to be achieved in biomimetically structured marble. The new biomimetic protection and functionalization concept of BioProMarL has a high innovation potential and holds great promise for technological impact, while the success of LiNaBioFluid strongly supports its viability. In particular, it is foreseen that the useful life of natural stone products can be increased and chemically aggressive sealants can be replaced through smart functional surface morphologies, strongly contributing to environmental sustainability. In addition, biomimetic marble with added functionalities might lead to an increase in market share of natural stone products and impulse the European market leadership.

Keywords: natural stone,marble,construction materials,acidic attack,environmental contamination,biomimetic,protection,laser processing,sustainable access,resource efficiency
Silk Aquamelts to Market (SAM)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 125000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Silk Aquamelts to Market (SAM) will catalyse the process of bringing Spintex Engineering’s silk aquamelts, as high-performance artificially spun fibres, to the medical market. SAM aims to fully commercialise our bespoke silks, for novel healthcare solutions. Objective 1 starts with a market analysis of medical biotextiles and their patent landscape. A dedicated research analyst will identify networking, commercial and regulatory opportunities/challenges for our company’s novel and unmatched fibres. Sharing the results of this work, the market analysis will provide a detailed feasibility study for silk aquamelts in the biotextiles sector, assisting further developments from FLIPT members and their own roadmapping work which is currently textile focused. By focusing on healthcare SAM will target a market with attractive profit margins, and demonstrate the viability of the aquamelt pathway in a heavily regulated industry. Objective 2 will tackle this regulatory compliance and certification in Good Manufacturing Practice (GMP), and ISO 10993 & 13485 for our silk aquamelts. By training key personnel in compliance with ISO standards and GMP, audit certification with EU notified bodies and receipt of CE marks will be achieved and individuals upskilled. We will demonstrate silk aquamelts’ utility and safety and add value to FLIPT, by expanding the opportunities available for other aquamelt materials and assisting their route to market. Furthermore, contact with investors, customers and at conferences, will establish the aquamelt pathway as the future of EU fibre production. This will directly benefit the uptake of future aquamelt developments from the FLIPT project and help several key work packages and tasks.

Keywords: aquamelts,silks,biotextiles
Printing personalised medicines on demand (PrintMed)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2022-12-31
Duration (months): 26.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact dose of drugs on porous substrates. This proof-of-concept project is based on knowledge we acquired during my ERC AdG project on processes of printing on paper using inkjet printing. We will demonstrate the viability of "printing" highly accurate amounts of a solution containing levothyroxine, prescribed for hypothyroidism, onto a porous tablet. Modelling tools will be combined with cutting-edge characterization technologies to push the understanding of printed drug-containing inklike solutions in porous dosage unit matrices. This project will transfer pharmaceutical formulation and product design of individual dosage forms with the use of inkjet printing technique to the pharmaceutical community. They can work on clinical approval tests of the developed oral dosage forms and move these products toward clinical use. The patients will benefit directly from development of this production technique, because a much more effective and targeted medication can be provided. The next step will be the development of the inkjet printing technique for other personalized medicines such as pain killers for children, hormones, biomacromolecules, psychoactive and anticancer drugs. Individually-dosed medicines will allow for substantial decrease of drug waste and thus overall reduction of medical expenses.

Keywords: pharmacy on demand,individually dosed tablets,inkjet printing medicine,digital design tool,pore scale modelling