Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Edu-Arctic – Innovative educational program attracting young people to natural sciences and polar research (EDU-ARCTIC)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Iceland,Norway,Poland,Poland,France,Faroe Islands
Call: Innovative ways to make science education and scientific careers attractive to young people (H2020-SEAC-2015-1, 2015)
Start date: 2016-05-01
End date: 2019-07-31
Duration (months): 39.0
Total project cost (EUR): 1798028.75
EU funding (EUR): 1798028.75
Participants: 6
Project status: CLOSED

The general objective of the EDU-ARCTIC project is a cross-country adaptation of innovative practices in science education in Europe. EDU-ARCTIC will provide a custom-designed large-scale program to strengthen schools’ science education. EDU-ARCTIC will use innovative online tools for interactive open-access available for everyone to link Arctic research and school education in Europe. The program is dedicated to young students in the age of 13 to 20 and their teachers. The program will be based on 5 main components: 1) Broadcasts (webinar transmissions) of online lessons from polar stations on natural sciences and polar research related to important societal challenges. The content of webinars will be adopted to school curricula at various levels (regional, national and European); 2) “Polarpedia” – an online developing encyclopedia with scientific expressions, educational resources and dictionaries in at least 5 national European languages; 3) Arctic competitions for European pupils cooperating with their teachers, in which prize winners will be able to participate in polar expedition; 4) Monitoring system: all schools in Europe will be invited to participate in a program based on monitoring of phenological observations in schools’ surroundings, a web based portal for registrations and access to accumulated data. 5) Teachers workshops and trainings. The novel educational programme elaborated within EDU-ARCTIC will give European pupils the opportunity to get insights in Research and Innovation process by access to (two-way communication) lecture transmissions from polar stations, participation in arctic competitions and environmental monitoring in their own surroundings. The interaction with real-time scientific work will contribute to increased interest among young boys and girls in choosing STEM careers. The innovative EDU-ARCTIC program will attract young boys and girls by its novel approach to STEM skills, especially science.

Keywords: stem skills,arctic,educational programme,polar region,interactive education,e learning
Investigating bacterial strain evolution through metagenomic genome assemblies (PopMet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Recent advances in metagenomics have revealed considerable genetic variation among the microbes that populate the human gut. It has been shown that multiple strains of a bacterial species can coexist in a microbial community. However, accurately differentiating strains in metagenomic samples is mostly not possible, even though pathogenicity is usually strain specific. Therefore, I propose to utilize single nucleotide variants (SNVs) to (i) identify and delineate bacterial strains and to (ii) reconstruct single strain genomes. As more than 1,000 metagenomic samples are available, a large database of bacterial genomes from natural environments will be built and made publicly available. This will give the opportunity to investigate the role of adaptive evolution, mutation rate variation between hosts and the colonization history of bacterial strains among humans, all with high confidence due to the sheer data volume. Further, I plan to explore rare SNVs (nucleotide variants segregating at very low frequencies) that many population genetic methods are reliant on. This will be of particular significance, as it will provide insights into growth dynamics of bacterial communities in natural environments, benefiting both evolutionary and clinical research. Thus, the PopMet project is the application of POPulation genetic analysis on large METagenomic datasets.

Keywords: metagenomics,deep sequencing,comparative genomics,bacterial evolution,speciation
ONLINE Platform for Smart Specialisation Policy Advice (ONLINE-S3)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Slovakia,Finland,Greece,Slovenia,Belgium,United Kingdom,United Kingdom
Call: On-line mechanisms for knowledge-based policy advice (H2020-ISSI-2015-1, 2015)
Start date: 2016-05-01
End date: 2018-06-30
Duration (months): 26.0
Total project cost (EUR): 3889000.0
EU funding (EUR): 3889000.0
Participants: 13
Project status: CLOSED

This project aims to develop an e-policy platform augmented with a toolbox of applications and online services, which will assist national and regional authorities in the EU in elaborating or revising their smart specialisation agenda, in terms of policies and strategy. The platform will leverage existing methodologies, initiatives and tools developed by the EC for the RIS3 strategy, but it will also investigate, develop and test new and innovative technologies, tools and services aiming to strengthen the European capacity for knowledge-based policy advice. The platform and the accompanied services will constitute an online mechanism for policy advice, integrated with a well-defined, commonly accepted and broadly used methodology for regional policy (RIS3 Guide). Data and sources of information to feed the platform and the services will be collected from institutional websites, RSS feeds, online databases, newsgroups and web forums, social networks data, web analytics, content management systems, measurement scoreboards, focus groups, and other online mechanisms for collaboration and policy co-design, and assessment. Taken together, these elements and architecture of integration will offer online all the necessary tools, methods, and roadmap to assist the elaboration, implementation, and impact analysis of smart specialisation policies.

Keywords: online mechanism,policy advice,e policy platform
Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy (INNODERM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Italy,Germany,France,United Kingdom
Call: Cross-cutting ICT KETs (H2020-ICT-2015, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 4595125.0
EU funding (EUR): 3869879.13
Participants: 6
Project status: CLOSED

Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-resolution optical mesoscopy and macroscopy and by (3) novel label-free anatomical, physiological and molecular contrast at the tissue and single-cell-level, based on spectrally-resolved optical absorption. MSOT, originally supported by an ERC Advanced Award (2008) (TUM: Prof. Ntziachristos), is already commercialized by iThera Medical for macroscopy with systems sold around the world for small animal imaging. In parallel, ERC MSOT funding developed a mesoscopic implementation, termed raster-scan optoacoustic mesoscopy (RSOM), which has demonstrated innovative imaging capacity at 1-5mm depths. Driven by leading dermatologists (TUM: Prof. Biedermann; SUR: Prof. Costanzo) and market leader SMEs in optoacoustic and ultrasound technology (iThera, Rayfos, Sonaxis), INNODERM will design and prototype a handheld, portable, scalable, label-free RSOM device for point-of care dermatology applications, based on recommendations developed under an ERC proof of concept grant (2013) on MSOT. INNODERM brings together key photonic & ultrasound technologies and will validate the technical and economic viability of RSOM in dermatology suites for fast diagnosis and skin disease monitoring. RSOM can go beyond the abilities of current optical or optoacoustic devices and offer a paradigm shift in dermatology imaging, substantiating successful business cases.

Keywords: raster scan optoacoustic mesoscopy,multispectral optoacoustic tomography,optical coherence tomography,handheld,imaging
Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment (HAZARDOmics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

Keywords: ion mobility spectrometry,capillary electrophoresis,effect biomarkers,bisphenol a,pcbs
INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition. (INSPIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel,Germany,Germany,Belgium,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-05-31
Duration (months): 53.0
Total project cost (EUR): 4021968.6
EU funding (EUR): 4021968.5999999996
Participants: 11
Project status: SIGNED

New drug candidates often have off-target effects resulting in adverse events, thus representing a major limitation for drug R&D. Safety Pharmacology (SP) aims to detect, understand and reduce undesirable pharmacodynamic effects early-on. Especially, cardiovascular (CV) toxicity is problematic, as it is the most prevalent reason for failure during preclinical development. Moreover, CV toxicity remains a key reason for drug attrition during clinical development and beyond. This indicates current SP screens fail to detect a number of (late-onset) functional or structural CV toxicities. Additionally, SP uses a significant number of laboratory animals, thereby creating opportunities for a better implementation of the 3Rs. The vision of INSPIRE is to advance and “inspire” SP by exploring new technological capabilities (WP1), addressing emerging CV concerns (WP2) and delivering new validated solutions for CV safety screening (WP3). To this end, INSPIRE unites expertise from academic teams, technology-providers, pharmaceutical companies, regulators and hospitals to create a European training platform for 15 Early Stage Researchers (ESRs). Key innovative aspects of INSPIRE include: i) in vitro humanized cardiomyocytes assays, ii) unparalleled in vivo hardware/software solutions, iii) in silico predictions of haemodynamics, iv) mass spectroscopy imaging of drug exposure, v) exploration of mechanisms of late-onset CV toxicity, as observed in cardio-oncology, and vi) early integration of feedback from industry and regulators. Overall, INSPIRE constitutes a multidisciplinary and intersectoral training programme (WP4) with a balanced combination of hands-on research training, intersectoral secondments, local courses and network-wide events on scientific and transferable skills, enabling future R&I collaborations. Hence, INSPIRE will equip the future generation of SP scientists with a wide range of scientific knowledge and the ability to adapt to a dynamic ever-changing industry.

Keywords: safety pharmacology,cardiovascular toxicity,cardio oncology
Sharing Gains from Trade: Global Markets and Farmers Welfare in Developing Countries (SharingGains)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1996009.0
EU funding (EUR): 1996009.0
Participants: 1
Project status: SIGNED

The majority of the global poor live in rural areas and earn their livelihoods in agriculture. Linking farmers in developing countries (LDCs) to global markets, therefore, could potentially spur growth and reduce poverty. Market imperfections in agricultural chains in producing countries, however, limit these gains. Which policy tools, if any, help farmers in LDCs realize and share the gains from trade? I propose three broad projects that develop the tools to answer this question. The first project designs and implements the first randomized control trial (RCT) to test for the causes and consequences of market failures interacting along multiple layers of agricultural value chains. This is a necessary step to design targeted policy responses. The second project develops and estimates the first structural model of an agricultural value chain to evaluate different regulatory interventions. Historically, as well as today, governments have intervened in agricultural chains through a diverse array of policies and regulations. RCTs are not sufficient to evaluate these policies. The project develops flexible tools to perform counterfactual analysis and evaluate the merits of alternative policies and regulations in a variety of contexts. The third project studies voluntary sustainability standards (VSSs) (e.g., Fair Trade, Rainforest Alliance). VSSs are increasingly popular responses to market failures in agricultural chains in LDCs. Unlike regulatory interventions, VSSs directly affect only market participants that take them up. The project combines quasi-experimental and structural techniques to evaluate the direct impact, the indirect spillover effects, and the broader distributional consequences of VSSs. The three projects form a coherent research agenda that develops a comprehensive set of tools to evaluate existing agricultural policies and design better ones so that small producers in developing countries can realize and share the gains from globalization.

Keywords: value chains,market failures,rcts,structural estimation
Knock prevention and increase of reliability and efficiency of high power gaseous internal combustion engines (Knocky)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Poland,Finland,Poland,United States,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 936000.0
EU funding (EUR): 927000.0
Participants: 7
Project status: CLOSED

Several R&D centres herein undertake the investigation of the reduction of the abnormal combustion phenomena of knock in internal combustion engines. Combustion knock limits the efficiency of the engine and deteriorates engine performance while simultaneously contributing to engine destruction, hence reduces engine reliability. Reducing or eliminating combustion knock increases durability and also engine efficiency, hence reducing CO2 emissions. The inter-sectoral research encompassed in this proposal concerns high-power stationary engines fuelled with gaseous fuels working in combined heat and power (CHP) systems. The proposal intends to apply a multidisciplinary approach to knock investigation encompassing fuel chemistry, combustible mixture preparation, ignition phenomena, flame propagation, knock detection and its prediction. Both modelling studies and experimentation in these fields will be performed. As result of the synergies and breadth of expertise, a resultant acceleration in research finding is expected with complementary investigation conducted within both the companies (Wartsila, AVL, Motortech) and universities involved that finally should result in solving the related challenges. Knowledge exchange will be done by research staff secondments, where experienced scientists will work both as advisors and active researchers in the ongoing projects. Engineers coming to universities will be familiar with original techniques for data acquisition as well as methods for signal processing and theoretical analysis of combustion process in the engine. Young research staff from companies will have opportunities to work with academic mentors. Further academic staff will become familiar with industrial approaches to research extending the knowledge. Knowledge transfer will be also done through regularly scheduled seminars and webinars. This collaboration and staff exchanges between the participants build lasting ties and continued after project termination.

Keywords: internal combustion engine,gaseous fuels,abnormal combustion,knock,spark ignition,engine control system,chp set
Treatment of Animal Waste to Reduce Gaseous Emissions and Promote Nutrient Reuse (Treat2ReUse)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-18
End date: 2022-02-19
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Intensification and industrialization of livestock operations lead to the production of large and spatially concentrated amounts of animal manure. If not properly treated or utilised, manure has significant negative impacts on the environment. Livestock production is the largest contributor to ammonia emissions of increased concern in the EU and low emission manure management technologies are needed. However, less than 8% of the livestock manure produced in Europe is processed, with large variations within regions. Furthermore, properly treated manure could serve as a valuable source of organic matter and nutrients for fertilizing crops and for energy production, replacing current fossil-based products. The current project aims to develop a new and efficient treatment technology to reduce environmental impacts from animal manure which will make a substantial contribution for a more sustainable and environmental friendly agriculture practice, gaining economic value from the reuse of treated manures to replace mineral fertilizer, contributing to a biobased and circular economy. The project will cover fundamental understanding of mechanisms involved in different acidification treatments, the development (with industry) of a new and sustainable acidification practice, and improving the fertiliser value of products. Project outcomes will be i) reduction of gaseous emissions with safer practice on farms and ii) a gained value from reused products, limiting the dependence on mineral fertilizers. My past professional and research experience gives me confidence in my capabilities to develop, innovate and implement the new methodologies to be employed in the project. Together with the experience and facilities of the host and partners, this guarantees the successful completion of the project, at a time at which this research is highly relevant to current societal and environmental needs, as well as strengthening of my career development.

Keywords: agriculture environmental impacts,manure management,gaseous emission,acidification,manure reuse,mineral fertilizer,soil,fertilizer value,environmental friendly,biobased economy