Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the Role of Enhancer Methylation Variation in Cancer and Developing Enhancer-based Markers and Targets for Precision Medicine (ONCOmetENHANCERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Cancer is a growing medical problem which genetic and environmental basis is not clearly understood. Massive efforts over the last decade have identified differences in cancer gene expression that cannot be explained by coding sequences or promoter variations, whereas the effect of transcriptional enhancers remains unclear due to the lack of an effective way to link enhancers with their controlled genes. Recently, we discovered a class of inter-tumor, inter-patient DNA methylation variations in putative enhancers that predict changes in gene expression levels with much greater power than promoter or sequence analyses. The overall goal of this proposal is to determine if changes in enhancer methylation form part of the genomic basis of cancer. Our aim is to elucidate methylation-influenced disease regulatory circuits that affect cancer driver and risk genes and may ultimately serve as markers for disease progression and drug response. Utilizing a new genomic methodology, which allows systematic prediction and verification of gene-enhancer pairing, I will test the above hypothesis in two disease models: breast cancer and glioblastoma. I will methodologically assess numerous potential enhancers across the disease genomes and explore the effects of genetic and epigenetic mutations and variations at these sites. Informative sites will then be evaluated as markers of gene expression level in tumor biopsies. Ultimately, I will apply novel tools to manipulate selected enhancers genetically and epigenetically, thus investigating the causal relationships between enhancer methylation and gene expression, and assessing the potential for tuning gene expression levels by enhancer methylation modification. This study may transform our understanding of the mechanisms underlying disease predisposition, determine the regulatory circuits of key disease genes, lead to improved diagnosis and predictive abilities, and may pave the way for precision epigenetic therapy.

Keywords: cancer predisposition,transcriptional enhancers,epimutations,regulatory mutations,epigenetic therapy,precision medicine,cancer methylation,oncotypedx
Rethinking Work: Intellectual Responses to the 2008 Financial Crisis in French Film and Media (WORKRETHINK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Social critics have observed how, since the 1970s, many forms of work have become increasingly redundant due to technological advances. At the same time, Europe has witnessed economic crises, financialization, growing inequality and debt, yet also responses to these phenomena in, for example, movements advocating debt relief and a citizens’ basic income. These issues have become particularly acute in the wake of the 2008 financial crisis. In France since the crisis there has been an increase in rhetoric surrounding the notion of work as well as many films engaging with this issue. My project will investigate the contemporary French critique of economy and how film and other audio-visual media have been used to communicate that critique. Responses to the crisis by intellectuals and filmmakers often involve a reconceptualization of work. A key focus will be to investigate the communicability of complex philosophical, economic and sociological ideas through films and other audio-visual media. This will encompass the appearance of intellectuals and their ideas in such forms as documentary, fiction, art film and satire, but also the use of online pedagogical videos by such individuals. Setting such ideas and media in their social, political and historical context, I will also report findings on the reception of these phenomena. While previous research on work in film has tended to focus on industrial labour, I want to make an intervention in the field by looking at contemporary forms of work, especially that of the financial sector which generally remains hidden from public view. I will develop my skills at the host institution, where cutting-edge academic work on film is being conducted, while France more generally is the site of the texts I shall study and whose authors I hope to interview. Outputs will include screenings, seminars, journal articles and a conference. These will galvanize interest and help improve understanding of an urgent problem affecting Europe.

Keywords: work,film,philosophy,europe,economy
5G for Smart Manufacturing (5G-SMART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Italy,Germany,Hungary,Sweden,Switzerland,Finland,Sweden,Sweden,France,United Kingdom,Brazil
Call: Advanced 5G validation trials across multiple vertical industries (H2020-ICT-2018-3, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 10210413.75
EU funding (EUR): 10200413.75
Participants: 19
Project status: CLOSED

Today smart manufacturing sector is undergoing a digital transformation addressing the challenge of reducing manual processes and increasing efficiency. 5G is foreseen as key enabler for the future manufacturing ecosystem termed Industry 4.0. 5G-SMART unlocks the value of 5G for smart manufacturing through demonstrating, validating and evaluating its potential in real manufacturing environments. 5G-SMART trials will test the most advanced 5G integrated manufacturing applications such as digital twins, industrial robotics and machine vision based remote operations by bringing first ever 5G deployment in manufacturing setup. 5G-SMART will undertake the evaluation of Electromagnetic compatibility (EMC), channel measurements and co-existence between public and private industrial networks in real manufacturing environments easing the integration of 5G. The new 5G features, developed in 5G-SMART such as time synchronisation and positioning for manufacturing use cases represent a technological leap. To further accelerate the take-up of 5G in the manufacturing ecosystem, 5G-SMART will explore new business models, including the roles of mobile network operators. 5G-SMART will result in the development of future 5G standards for the manufacturing sector complemented by new 5G enabled manufacturing products and solutions. 5G-SMART open days will directly address small and medium enterprises making 5G-SMART technology accessible to them. 5G-SMART lead by Ericsson brings together a strong consortium of partners involved in every aspect of the manufacturing ecosystem.

Keywords: smart manufacturing,5g demonstration,trials,measurements,non public networks
The circadian clock in day-active species: preserving our health in modern society (DiurnalHealth)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France,Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2026-06-30
Duration (months): 82.0
Total project cost (EUR): 2233250.63
EU funding (EUR): 2166755.63
Participants: 2
Project status: SIGNED

Due to a significant increase in the use of artificial light in our 24h economy, the biological clocks of all living organisms, including humans, are severely disrupted. Many severe health disorders are consequences of clock disruption such as diabetes, sleep/mood disorders, cardiovascular disease, and immune dysfunction. The central timekeeper in mammals is the suprachiasmatic nucleus (SCN), and the mechanisms by which light disrupts integrity of the SCN has been well investigated in nocturnal species. In contrast, mechanisms of clock disruption in humans and other diurnal (day-active) species remain poorly defined. I have evidence that the mechanisms that drive SCN function are fundamentally different between nocturnal species and diurnal species. This defines my aim to restore proper clock function in diurnal species, including humans. To test this, in Objective 1 we will identify similarities and differences between nocturnal and diurnal clocks with respect to their i) response to light, ii) neuronal synchronization, iii) output, and iv) response to physical activity. Based on these findings, in Objective 2 we will develop novel strategies to manipulate and restore clock function in diurnal species. These objectives will be achieved using novel, state-of-the-art chronobiology methods including in vivo electrophysiology and Ca2+ and bioluminescence reporters—all in freely behaving day-active animals, as well as in slice preparations containing the SCN. For studies on the human SCN we record with 7-Tesla fMRI. This proposal will help establish a new basis for chronobiology with respect to the most suitable models for studying translational applications. The results will yield immediate benefits in terms of manipulating biological clock function among vulnerable populations in modern society, particularly the elderly, patients in intensive care, and shift workers.

Keywords: circadian,in vivo electrophysiology,neuronal network,neurophysiology,light input,light pollution,seasonal rhythms,exercise,health,synchronization,sleep,behaviour,plasticity
Estonian Presidency Research Policy Conference ‘European Research Excellence - Impact and Value for the Society’ (EExres)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Coordination and support actions
Countries involved: Estonia
Call: Presidency Conference ‘Expanding Excellent Science for the Benefit of Society’ (H2020-IBA-SC6-Expand-2016, 2016)
Start date: 2017-06-01
End date: 2018-03-31
Duration (months): 10.0
Total project cost (EUR): 207781.25
EU funding (EUR): 179656.0
Participants: 1
Project status: CLOSED

The international high-level conference will be organised during the Estonian Presidency of the European Union Council in Tallinn in October 2017. The conference aims to demonstrate the impact and value of excellent research to the society and thereby strengthen political commitment to ambitious public investments in research in Europe. It encourages to take a perspective that goes beyond short-term gain, and to develop a long-term vision for European research and innovation policy. Research and innovation are pillars of the Europe 2020 Strategy to put Europe back on the path to smart, sustainable and inclusive growth. At the same time, we can observe strong pressure on the research budgets across Europe. The conference has three specific objectives: • Contribute to better communication of the impact and value of bottom-up and interdisciplinary excellent research in increasing EU competitiveness and creating a better future for the society. We want to demonstrate to policy-makers, stakeholders and wider public that excellent bottom-up research is the catalyst of societal development that provides practical solutions for society. • Broaden the understanding on research impact that goes beyond short-term economic stimulus, including impact to policy-making, society, culture and systemic impact. In light of the discussion of the next Multiannual Financial Framework (MFF), discuss how the current macroeconomic models could better take into account the longer-term impact and benefits of investments in R&I. • Contribute to the debate on the future of European research policy in the lead-up to the next Framework Programme. The outcome of the EU Presidency conference will be presented in the final declaration Tallinn Call to Action. Tallinn Call to Action is emphasising the importance of excellent research for the future of Europe; it is about changing research and changing Europe.
LOW MAINTENANCE, HIGH SECURITY, PIPELINE LEAK DETECTION THROUGH CONTINUOUS MONITORING AND REAL TIME ALERTS (LIMPET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Dashboard is an early stage technology company formed to develop and market an automated remote monitoring solution for the collection and consolidation of near-real-time data from sensors in both remote and accessible locations. As a cleantech company Dashboard is rooted in the transformational power of data analytics, and through the knowledge and skills of our experienced team of hardware, programming and communications professionals, has developed Limpet, an alternative solution to monitoring pipelines for leaks and breaches. The global pipeline industry has a growing problem with leak and breach detection, costing billions and causing long lasting and highly destructive environmental damage. Limpet is at the forefront of improving low cost oil and gas pipeline monitoring, limiting the economic and environmental impact of any leaks or breaches. The solution, through the utilisation of novel ultrasonic flow rate measurement and innovative collar design, offers vastly improved detection rates, cheaper installation and running costs per km, improved device lifecycle, retro-fitting capabilities and advanced cyber security of both the device and data. The result is a potential installation saving of $999,250 per km and a yearly saving of $16,800 per km. This feasibility study is designed to verify the technical, market/commercial and financial feasibility of Limpet, cumulating in a detailed report that will contain an optimal design plan, skills analysis, IPR strategy, market/competitor report, financial model for commercialisation and risk analysis. The commercialisation of Limpet, initially in the EU, will see the solution positioned as the market leading flow rate leak detection system for oil and gas pipelines. The primary target will be EU companies with existing or planned onshore, above-ground pipelines. By the 4th year of commercialisation we expect to generate revenues of €30m, have a team of 73, and have a leading position in the leak detection market.

Keywords: pipeline leak,detection,real time,monitor,algorithm,global,encrypted data,flow rate monitoring,ultrasonic,cyber security,environment,resource efficiency,data analytics,automated
Corporate (ir)responsibility and the politics of collective memory. (CSR_MEMORY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project aims to provide understanding on why and how we as societies often forget instances of corporate irresponsibility over time, and thus fail to hold firms accountable over the long term, and expose ourselves to recurring trauma. Literature on political CSR has emphasized the active role firms take in influencing their surroundings, while recent research has highlighted the relatively low salience over time of many events of corporate (ir)responsibility. The concept of collective memory offers a lens for interrogating corporate pasts and into why and how we collectively remember and forget meaningful events of corporate irresponsibility, and how corporations may influence this process. This has implications for the efficacy of stakeholder pressure - or voluntary corporate social responsibility - as a mechanism for controlling the negative externalities caused by firm activity, which is particularly significant because of how CSR has become a policy tool for the EU and nation states. This project is a two-tier empirical study into the remembering and forgetting of instances of corporate irresponsibility. - The first part is an in-depth case study combining automated content analysis and discourse analysis of newspaper data in order to identify communications strategies and related discursive practices that can be utilized to influence the content and form of mnemonic traces of firm events. - The second part is a qualitative comparative analysis of a range of cases of corporate irresponsibility in order to identify the conditions and mechanisms through which instances of irresponsible firm activity are institutionalized, reconfigured, and forgotten in collective memory. The excellent research infrastructure of the beneficiary and the secondment organization and the learning of cutting-edge methodologies would provide me exceptional opportunities to kick off my career as a full-fledged academic researcher, and would be of benefit to the citizens of EU.

Keywords: corporate social responsibility,collective memory
Re-inventing Ecosystem And Land-surface Models (REALM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2499615.0
EU funding (EUR): 2499615.0
Participants: 1
Project status: SIGNED

Terrestrial ecosystems respond to changes in climate and the atmospheric environment, which they in turn help to regulate. As global change has become an international concern, high expectations have been laid on Earth system models with embedded ecosystem and biophysical land-surface components to deliver reliable, quantitative predictions of large-scale changes in ecosystems and their feedbacks to the climate system. But the lack of established quantitative theory for many fundamental processes – such as the long-term effects of temperature on primary production and carbon allocation, the sustainability and nutrient requirements of CO2 ‘fertilization’, and the regulation of green vegetation cover and its water use – has made such expectations impossible to fulfil. As a result, numerical models of land ecosystem processes continue stubbornly to disagree both with one another, and with benchmark data sets. This impasse can be overcome, but not without re-thinking modelling practice. Theory must be re-instated as the required link between observations and models. Multidisciplinary data resources now available should be used far more extensively and creatively. Observational and experimental results should be integral to model development, not merely used for ‘end-of-pipe’ testing of complex, poorly constrained models. I propose to develop a comprehensive, next-generation vegetation model using eco-evolutionary optimality hypotheses to generate testable predictions, and multiple data sources to provide tests. Initial results have demonstrated the remarkable power of this ‘strong inference’ approach to explain patterns seen in nature. The project will transform the practice of global vegetation and land-surface modelling and in doing so, establish the foundations of a more robust, quantitative understanding of the role of terrestrial ecosystems in Earth System dynamics.

Keywords: dynamic global vegetation model,earth system model,plant functional traits,optimality,carbon cycle,acclimation,ecohydrology,land surface model,primary production,biome distributions,carbon allocation