Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cooperative Mobile Network Optimization (COMONO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 172618.8
EU funding (EUR): 172618.8
Participants: 1
Project status: CLOSED

This proposal targets some crucial challenges of LTE, the next generation mobile communication system beyond 3G. From the strict technological point of view, the proposal promises to develop novel methods for the problems of optimal radio resource allocation and intra/inter-system handover. To achieve this goal the idea is to introduce cooperativity into the control mechanisms, i.e. the aim is to propose distributed algorithms involving various elements of the network (i.e. both the mobile nodes and the different components of the access network) into the decision making. Using this approach the users are directly involved into the control processes of the network, which raises important privacy and security issues. These questions will also be investigated. In order to evaluate the proposed solution, an efficient and accurate system level LTE simulator will be developed as an extension of the simulator that has been developed at the host - CWiND.

Keywords: distributers algorithms,mobile networks,radio resource management.
Unveiling the history of the Galaxy with its fossil stars (GALFOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 163702.68
EU funding (EUR): 163702.68
Participants: 1
Project status: CLOSED

The history of our Galaxy, the Milky Way, has been always a subject of debate. How the Galaxy was formed and the ways it has evolved up to the present moment is still something that it is outside our knowledge. Nowadays, we are living an extraordinary scientific moment, since after incredible efforts the technological facilities necessary to disentangle such a relevant matter are available. The study of the fossil stars of the Galaxy, the white dwarf population, is essential to obtain information about its past history. In particular, the cooler objects are the ones that can provide more interesting information, but they are so faint that the current number of identified objects is very low. The project we propose will overcome all the current problems to detect cooler white dwarfs by performing a deep survey of thick disk and halo WDs in a very deep infrared survey (WTS) carried out in the zyJHK filters with the UKIRT telescope. The accuracy of these data will allow us to classify them in thin/thick disk or halo members. Thanks to the new cool white dwarfs detected we will be able to cover the low luminosity end of the thin disk/thick disk/halo luminosity functions, which will provide a wealth of information about the history of the Galaxy (age, star formation rate...).

Keywords: physical sciences,astronomy,astrophysics
Into the twillight zone: testing jet launching and collimation engines with near-infrared and (sub-)mm interferometry (TWILIGHTZONE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2010-08-31
Duration (months): 16.0
Total project cost (EUR): 153690.64
EU funding (EUR): 153690.64
Participants: 1
Project status: CLOSED

The quest for the origin of stars and planets is one of the main thrusts of modern astronomy playing a leading role in the science cases of new instruments and infrastructures, in the ground and space. A major open question in this field is the understanding of the physical mechanisms responsible for the launching and collimation of jets and winds from young stars. Such a mechanism is of wide astrophysical significance as it is thought to operate in young stars, AGNs, micro-quasars and gamma-ray bursts. The remarkable combination of larger angular size and line emission make young stars ideal laboratories for such studies. Wind launching has further dramatic consequences on the angular evolution of the star-disk system and radically changes the planet forming disk properties in the inner disk regions where solar system rocky planets and extra-solar hot jupiters are found. The present research programme aims at the career development of the fellow leading to a position of scientific excellence and autonomy after several years of teaching and administrative duties. The programme is highly interdisciplinary, it combines observational predictions of state-of-the-art MHD models using radiative transfer tools with leading front-line observational techniques exploiting synergies in near-infrared and (sub-)mm interferometry. Such a programme anchors on the match of the fellow profile combined with the outstanding training and scientific capacity of the host. In the short term it will allow direct constraints on the launching and collimation mechanism. Lasting impact will be achieved by equipping the fellow with the capacity to lead scientific programmes in top world infrastructures where Europe has a leading role such as the Very Large Telescope Interferometer and the coming ALMA array. Upon returning to its home institute the fellow will be transferring know-how contributing to the excellence and the integration of peripheral countries in the European research area.

Keywords: astronomy,astrophysics
Multiwavelength variability study of the jet variability in X-ray binaries. (JETVAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 162568.66
EU funding (EUR): 162568.66
Participants: 1
Project status: CLOSED

Jets appear to be ubiquitous in accreting systems, but the origin of the observed accretion disc-jet coupling remain largely unknown. In this project we propose to use a twofold, observational and theoretical, approach to study and understand the internal physics, structure and variability of jets in accreting black holes, neutron stars and white dwarfs, as well as their coupling with the accretion disc. Observational approach: we will take advantage of newly available technologies on large telescopes, and we will apply advanced timing-analysis techniques to a wealth of data over the whole electromagnetic spectrum. The study of correlated fast multi-wavelength variability has a great and largely unexplored potential to help solving many open issues. Coordinated X-ray, infrared, optical and radio observations at high time resolution will unveil the origin of multiwavelength emission in accreting compact objects. To observe and identify the timescales of the variability at different wavelength is our best chance to study the physical processes, the accretion geometry that yield to the ejection of relativistic matter, as well as the geometry and variability of the jet itself. To compare the properties of correlated variability in accreting black holes, neutron stars and white dwarfs will allow us to investigate the role of the black hole spin in producing and powering the jet, and to unify for the first time the science of accretion and jet formation. Theoretical approach: we will support these observations with a deep theoretical effort, both numerical and analytical. The emission from jet internal shocks in the mildly-relativistic case will be modeled analytically, and the jet variability as a function of a variable accretion rate will be simulated. A self-consistent model for the jet structure and variability in X-ray binaries will be developed, and tested against the data.

Keywords: physical sciences,astrophysics
Development of Magnetic LbL Particles for Diagnostics (MAGNOSTICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-08-17
End date: 2010-10-16
Duration (months): 14.0
Total project cost (EUR): 170418.35
EU funding (EUR): 170418.35
Participants: 1
Project status: CLOSED

The project at hand aims at the development of new improved magnetic nano particles for diagnostics. These magnetic nano particles will then be incorporated in layer-by-layer capsules, which allow for a better detection of tiny amounts of analyte material in blood, urine and other body fluids. This innovative technology will significantly improve the reliability of the analysis of small amounts of bioorganic material and thereby facilitate medical diagnosis. If nowadays samples have to be sent to diagnostic laboratories for analysis, with the new technology every practitioner will be able to conduct diagnostic tests himself. Surflay, the Berlin-based host company for this project, is specialised in layer-by-layer technology and its application in diagnostics. However the necessary knowledge about the preparation of magnetic nanoparticles is missing. Therefore, Surflay plans to host Dr. Huang from Sichuan University, China for two years. Dr. Huang has achieved unique results on the preparation of magnetic nanoparticles. This project is meant to be the foundation of a long-term cooperation between Sichuan University and Surflay as well as other European network partner of Surflay.

Keywords: health sciences,physcial chemistry,nanotechnology,diagnostics,layer-by-layer-technology,magnetic nanoparticles
A comprehensive analysis of essential protein regulators of clathrin-mediated endocytic pathway (ENDOCYTIC REGULATORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 146050.52
EU funding (EUR): 146050.52
Participants: 1
Project status: CLOSED

Clathrin-mediated endocytosis is an essential molecular process involved in the maintenance of cell homeostasis of all eukaryotic organisms. It is indispensable for the uptake of nutrients and signaling molecules, for the proper composition of plasma membrane, and for the regulation of multiple signaling pathways. Since endocytosis is a primary entry point to the cell interior, its detailed knowledge is of key importance for many biomedical disciplines like immunology, neurophysiology and pharmacology. Studies on endocytosis at neuronal synapses or on its role during viral infection are just two examples of current research linked to potential therapeutic applications. Clathrin-mediated endocytosis is an elaborate, highly dynamic process assisted by more than 60 proteins, the majority of which is evolutionarily conserved. Different multiprotein modules are involved in the initial sorting of endocytic cargo, formation of an endocytic vesicle, and its subsequent scission and internalization. Although many components are known, molecular mechanism and spatiotemporal order of endocytic events are only being to be understood. Moreover, the key endocytic factors are essential, multifunctional proteins of modular structure, which greatly complicates their analysis in human. We plan to study the role of essential endocytic genes by combining quantitative real-time fluorescence microscopy with the powerful genetics of yeast Saccharomyces cerevisie. Crucial endocytic proteins will be depleted from the cell and endocytosis will be followed by live-cell imaging. Complementation assays with truncated/mutated constructs will be used to delineate the molecular details of missing function. Electron microscopy techniques will be introduced to reveal structures of obtained endocytic intermediates. The focus on critical endocytic factors studied by innovative multidisciplinary approaches should bring a significant progress in our understanding of this highly orchestrated process.

Keywords: cell biology,molecular biology,biochemistry,molecular design,live-time microscopy,digital image analysis,endocytosis,biological membranes,saccharomyces cerevisiae,yeast genetics
Multifrequency Tomography of the Reionization Epoch (TOMOGRAPHYEOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-22
End date: 2011-06-21
Duration (months): 24.0
Total project cost (EUR): 165655.46
EU funding (EUR): 165655.46
Participants: 1
Project status: CLOSED

We propose to use the CO emission lines and the signature that metals and ions leave on the CMB during reionization as a complementary window to H21 cm observations of that cosmological epoch. Since all those effects are associated to a given resonant frequency, different observing frequencies probe different redshits, and a tomographic study of reionization can be performed. Furthermore, these signals show a definite behavior versus the observing spectral resolution which is different from all potential foregrounds (which remain essentially constant), and this should allow for component separation. The CO and metal lines should arise in regions where star forming activity has taken place, and therefore are likely to give a *complementary* picture of reionization. In contrast, H21cm observations probe the neutral regions of the Universe, not yet affected by the UV radiation of the first stars. We propose to study all these effects in a common theoretical frame, validated by the analysis of state-of-the-art numerical simulations, and investigate the astrophysical and cosmological constraints that future observations will be able to set on reionization. This project becomes particularly timely with the advent of radio, millimeter and centimeter data from missions like LOFAR, ALMA, Planck, HERSCHEL, SPT or ACT. This is a field of great future perspective, and both the candidate and the host institution are ideally suited for this project, and both would largely benefit from it in a medium and large term.

Keywords: cosmology,reionization epoch
Low power high image quality display using colour sequential display technology (GREEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-10-15
End date: 2011-10-14
Duration (months): 24.0
Total project cost (EUR): 169992.41
EU funding (EUR): 169992.41
Participants: 2
Project status: CLOSED

There is growing awareness that our hunger for energy has a large impact on the environment. A significant amount of energy is consumed by electronic devices that we use. In Europe we consume 210,000 MWh a day watching TV. In China, power consumption will increase dramatically in the future. Liquid Cristal Display (LCD) is the major display technology for the coming 10 years. Although LCDs offer many benefits, they provide a relatively poor system solution in terms of power-efficiency. Unfortunately, the LC panel efficiency is limited to 5-7%. A good solution to reduce the power consumption is to remove the colour filters and generate the colour temporally. First prototypes have shown this successfully, but they suffer from severe colour breakup artefacts. The focus of the research carried out in this proposal is to find solutions that suppress colour breakup without the need for unrealistically high refresh rates. The hosting party published some first results using a 120 Hz colour sequential system with two colour filters and two colour fields. Although the colour break-up is reduced, it remains well visible for certain important classes of images. In the literature also other methods are described that could reduce the colour breakup, but they were unsuccessful to eliminate the colour breakup. IIF candidate,Y. Zhang, will develop new algorithms that drive the backlight and the panel in such a way that the colour breakup is reduced to an acceptable level. The hosting party also has excellent facilities for perception research and video processing development and testing, and has the hardware or the facilities to build the hardware required to study and test the colour breakup phenomenon. This project offers a unique opportunity to foster and further strengthen the existing collaborations between Europe and China in the display technology area. Environmentally, the power-efficient techniques resulting from the project will lead to globally important energy savings

Keywords: energy saving,electronic engineering,video processing,displays
COmpound 21 and MElatonin in CArdiovascular REmodeling (COME-IN-CARE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-08-01
End date: 2011-01-31
Duration (months): 18.0
Total project cost (EUR): 121598.2
EU funding (EUR): 121598.2
Participants: 1
Project status: CLOSED

Cardiovascular (CV) diseases are the major source of morbidity and mortality in the EU with annual costs of € 169 billion. The control of hypertension and prevention of left ventricular (LV) hypertrophy and fibrosis, which could interrupt the CV continuum, still remain insufficient world-wide. A substantial part of current therapies modulate the renin-angiotensin system (RAS) and decrease the unfavorable stimulation of angiotensin type 1 receptors (AT1R). Results of the host group indicate that many of AT1R effects are opposed by type 2 receptor (AT2R) activation. AT2R are up-regulated in several pathologies, making targeting of AT2R effective specifically in disease. The investigation of long-term effects of direct AT2R activation on hypertension and CV remodeling was allowed only recently by the discovery of AT2R agonist, compound 21. Fellows results suggest, that the pineal hormone and antioxidant, melatonin, prevents fibrosis and can be especially useful in combination with RAS modulation. We aim to investigate the effects of 5-week administration of compound 21, melatonin and their combination in L-NAME hypertensive rats on CV remodeling and relevant protein expression pattern. Advanced, interdisciplinary techniques from physiology to molecular biology will be implemented. The findings should indicate whether the exciting AT2R targeting is a promising approach to CV diseases and whether the use of a novel drug combination can preserve myocardial structural homogeneity. This project will yield important scientific and clinical implications and provide an outstanding training, guaranteed by excellent researcher in charge. Proposed training will unfold researcher’s creativity, networking and other complementary skills and promote his scientific maturity and independence necessary to create an own research group. Possible reintegration of the researcher with his enhanced scientific output will increase the competitiveness in his country of origin.

Keywords: cardiology,physiology,laboratory animal science,hypertension,left ventricular hypertrophy,fibrosis,renin-angiotensin-system,compound 21,melatonin
Role of Stem Cell Products for Alveolar Epithelial Cell Regeneration in Pulmonary Fibrosis (STEMPF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 171300.62
EU funding (EUR): 171300.62
Participants: 1
Project status: CLOSED

Pulmonary fibrosis (PF) is a progressively debilitating disease of unknown origin, with usual first presentation in 50’s plus age group. Over 500M people are afflicted by this disease world wide; however, this is an underestimate as incidence is rapidly rising as PF becomes better diagnosed. There is currently no efficacious therapeutic intervention which can either halt or reverse the disease process. Pulmonary Fibrosis carries a very poor prognosis of less than 3 years from diagnosis. Hence, PF morbidity and mortality imposes a huge socioeconomic burden as a chronic irreversible lung condition across the European Region, contributing significantly to the annual 102 billion Euros respiratory health cost and rising; most is due to hospital and community care support as well as early retirement / loss working days in those affected before 65yrs. There is a desperate unmet clinical need for PF patients across Europe and globally. PF thus presents a major therapeutic challenge. Recent research in PF pathogenesis suggests that inadequate regeneration of alveolar epithelium following presumed recurrent micro injury is a key factor in propagating development of fibrosis (over-scarring) within the lung. Whilst a number of plausible mechanisms may be responsible for this repair dysfunction in the alveolar epithelium, a likely hypothesis is that presence of a PF- related aberrant epithelial-mesenchymal transdifferentiation prevents a healthy epithelial cell – fibroblast balance. It follows that modulation of alveolar repair processes, and influence on fibro / myofibroblast transdifferentiation, represents a novel target in anti-PF therapeutics. Stem cells are at the centre of biomedical research for the treatment of many chronic debilitating diseases. We speculate that strategies involving use of human progenitor cells, such as autologous mesenchymal stem cells (hMSC), human embryonic stem cells (hESC) or their products for future treatment of lung fibrosis could be a

Keywords: health sciences,pulmonary fibrosis,stem cells