Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing a human-based stem cell model for reproductive toxicity (ReproTox)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-08-01
End date: 2026-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Environmental factors and chemicals are thought to be one cause of declining male fertility. Reproductive toxicity is becoming a major public health problem. Currently, new pharmacological or chemical compounds are tested in animals for their effects on reproduction before entering the market. This risk assessment is essential but time-consuming, expensive and is not always predictive in humans since animals have different reproductive characteristics and physiology. A validated and qualified human system to assess reproductive toxicity would be invaluable in addressing this conundrum between regulatory requirements and true relevance. Through my ERC-CoG, I have built a large repository of knowledge and developed robust technology on human in vitro gametogenesis, more specifically on how to generate male gamete progenitors from human pluripotent stem cells. This, together with my bioinformatics knowhow, makes me exceptionally well-placed to optimise a human-based high-throughput screening assay for male reproductive toxicity for use by the private sector in filing reproductive safety data to the regulatory authorities. This ReproTox assay will be further optimised (increase throughput, standardise measurements) and integrated with a software innovation (machine learning algorithm to automate quantification and webtool), before we carry out a pilot screen using FDA-approved spermatotoxic compounds and market research to define the commercialisation route. Reducing the number of compounds that show male reproductive toxicity at very early stages of drug development will contribute to an effective first-tier toxicity screening, not only providing standard protocols for quantitative, rapid, cost-effective, high-throughput, scalable and reproducible toxicity testing, but also reducing, perhaps eventually replacing animal use. ReproTox will ultimately lead to economic, societal, environmental, health and ethical benefits.
Electrocatalytic activity and dissolution stability of high entropy alloys at the atomic scale (HEACAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

The Covid-19 pandemic and the international conflicts are now having a significant impact on energy systems around the world, potentially slowing the expansion of clean energy applications. European energy safety can only be ensured by accelerating the development of cheap and clean energy. Catalysts for the chemical reactions in energy conversion and storage, such as fuel cells and water-splitting, are critical to achieve large-scale clean energy production. However, the scarcity of noble metals (such as Pt, Ir), currently the state-of-the-art catalysts, limit their apllications. Co, Fe and Ni oxides are proved to be earth abundant alternative catalysts. Corrosion of these transition metal-based electrocatalysts is inevitable, particularly for the oxygen evolution reaction of water splitting. Transition metal-based high entropy alloys (HEAs), the homogeneous “mixtures” at the atomic level of at least 5 transition metals, exhibit high electrocatalytic activity compared to binary oxides and also high corrosion resistance compared to stainless steels. These unusual properties of HEAs arise from atomically ordered but elementally disordered structures, which are poorly understood. I will explore, for the first time, the surface disorder of HEAs at the atomic scale, by synthesizing nanofilms of 5-element alloys in ultra-high vacuum (UHV) and using advanced surface analytical techniques (mainly STM, XPS). I will perform electrochemical measurements on synthesized model HEAs’ surfaces in a home-made movable reaction cell that can be connected to different UHV systems, in order to correlate atomic-scale structures with catalytic and anti-corrosion properties. I will merge my previous expertise in STM, XPS techniques and surface reactivity of ternary alloys into the host’s experience in thin film alloy synthesis and catalysis. The overall objective of this project is to find the balance between the activity and the stability of HEAs for water splitting electrocatalysis.

Keywords: scanning tunneling microscopy stm,x ray photoelectron spectrocopy xps,ultra high vacuum uhv,electrochemistry,high entropy alloys hea,nanofilm,catalysis,corrosion
Electronic Components and Systems for flexible, coordinated and resilient Distributed Renewable Energy Systems (ECS4DRES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Germany,Netherlands,Spain,Italy,Slovakia
Call: Focus Topic on Electronic Control Systems (ECS) for management & control of decentralized energy supply & storage (IA) (HORIZON-KDT-JU-2023-1-IA, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 27930499.07
EU funding (EUR): 8577941.75
Participants: 33
Project status: SIGNED

ECS4DRES targets the ambitious objective of pursuing flexible, coordinated, and resilient distributed energy systems developing several innovation activities, specifically: - realization of a multi-modal energy hub - exploiting renewable energy sources - realized by means of dedicated high-efficiency power electronics converters - multi-modal energy storage devices - sophisticated energy management algorithms enabling the local balances between energy production, storage, and consumption ECS4DRES will strengthen the long-term reliability, safety, and resilience of DRES by developing advanced monitoring and control technologies including integrated sensors provided with energy harvesting functions, capable of different types of detection for safety purposes, and for monitoring of energy transfers. ECS4DRES will also achieve interoperable and low-latency communication systems, as well as algorithms, AI tools and methods, enabling the widespread interconnection, monitoring and management of a large number of DRES, subsystems, and components to realize optimal energy management between sources, loads, and storages, to improve power quality and to enable resilient system operation. Most of all, ECS4DRES commits to perform a thorough validation of all the above with a set of 5 relevant use cases and demonstrators. By exploiting the project results, ECS4DRES will generate a wide range of scientific, technological, economic, environmental and societal impacts of global scale, fulfilling the needs of e.g., OEMs, DSOs, grid operators, EV charging station aggregators, energy communities, end customers, academia. ECS4DRES will provide interoperable and tailored solutions in the form of electronic control systems, sensor technology and smart systems integration for the deployment and efficient and resilient operation of DRES including integration of hydrogen equipment and components.

Keywords: power conversion,power quality,hydrogen,smart grid,microgrid
Decoding calcium pathway activated by plant intracellular immune receptors (DeCaETI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-03
End date: 2025-07-02
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Plant diseases have been causing global issues to agriculture, economy, and humanity. Understanding how plant disease resistance works is vital to finding durable and sustainable solutions to protect our crops. One key molecular hallmark of plant immune activation is mediated by calcium signalling, which is a commonly shared and well-known second messenger in all cellular organisms. However, it has been overlooked how calcium signalling is activated by plant intracellular nucleotide-binding and leucine-rich repeat immune receptors (NLRs), which are often one of the main genetic resources of plant breeding for disease resistance. In addition, upon activation, it is not known how the immune receptors activate a large scale of defence genes via calcium signalling. To answer these questions, I will be addressing three objectives: 1) Decoding compartmentalized calcium dynamics activated by intracellular immune receptors (NLRs); 2) Characterizing the role of helper NLRs in producing calcium signatures and transcriptional reprogramming; 3) Identifying calmodulins (calcium-binding proteins) that interact with key transcription factors to decode the calcium signature during effector-triggered immunity mediated by NLRs. I will use an interdisciplinary approach combining cell biology, genetics, and multi-omics. The outcome of this study will expand our understanding of plant immunity and provide novel insights for crop breeding specifically tailored to counter hazardous pathogens. I aim to 1) broaden my expertise in plant signalling research; 2) expand my toolbox of cellular biology and genetics; 3) develop the leadership skills required for managing a research group. Furthermore, I will strengthen my scientific track record and network. This DeCaETI project will be performed at the Institute of Biology Leiden, Leiden University. Implementation of the project will support me to run this project successfully and advance my career to become an independent future leader.

Keywords: calcium,calcium signalling,plant immune receptor,transcription factor,defence genes,arabidopsis thaliana,plant disease resistance
Central Africa Training Platform for Clinical Research on infectious diseases (CATCR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Gabon,Congo, The Democratic Republic of the,Cameroon,France,Germany,Congo,United Kingdom,Netherlands
Call: Global Health EDCTP3 Training Networks - Clinical Research Fellowships (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-11-01
End date: 2029-04-30
Duration (months): 54.0
Total project cost (EUR): 4846237.68
EU funding (EUR): 4846237.68
Participants: 9
Project status: SIGNED

The world is facing the silent “pandemic” of antimicrobial resistance (AMR). Central Africa has the highest mortality rate (23.5 deaths/ 100,000) attributable to AMR in the world. Research is desperately needed to better understand the burden of AMR in this region, and it is vital that this work is done by local researchers who will be the future leaders of scientific and clinical research in central Africa. The overall aim of the Central Africa Training Platform for Clinical Research on infectious diseases (CATCR) project is to produce essential, world-class research in central Africa, for central Africa, by central African people. To achieve this, it is crucial that the critical mass of PhD and PostDocs in central Africa is increased. Therefore, the consortium will (1) develop a multifaceted training programme on infectious diseases focusing on AMR for MSc, PhD and healthcare professionals; (2) develop a clinical fellowship programme of recruitment, training, evaluation and retention; (3) research the lack of knowledge on antimicrobial usage trends in patients with parasitic infections; (4) research the causal link between prevalence rates and influencing factors of carbapenemase-producing Enterobacterales (CPE) and occurrence of AMR in humans and livestock; and (5) research to understand the prevalence of tuberculosis (TB) and drug-resistant TB characteristics in Central Africa. Finally, (6) the project will focus on communicating, and disseminating research results. Through CATCR, talented researchers, clinicians and health care professionals working on AMR in central Africa will benefit from access to fully-funded fellowships to complete ground-breaking research. Public and regulatory authorities in Africa will use the research and newly established fellowships to develop vital AMR action plans and to increase the critical mass of researchers in the region will ultimately lead to benefits for patients and citizens of central Africa.

Keywords: antimicrobial resistance,central africa,training networks,scientific leadership,epidemiology,drug resistance,one health,mentoring,african researchers
ENABLING LARGE E-FLEETS PARTICIPATION IN POWER SYSTEMS OPTIMISATION THROUGH MASS DEPLOYMENT OF PEOPLE-FRIENDLY, LOW-COST INFRASTRUCTURE AND INTEROPERABLE VEHICLES (ePowerMove)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Belgium,United Kingdom,Finland,Cyprus,Austria,Slovenia
Call: Smart, low-cost pervasive stationary slow charging and bi-directional solutions synergic with the grid for EV mass deployment (2ZERO Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 9463644.25
EU funding (EUR): 7993719.25
Participants: 18
Project status: SIGNED

Electric car markets have grown exponentially in recent years and the trend continued strongly through 2023. The EU has passed legislation to match its electrification ambitions, and more R&D projects are being funded to develop affordable user-centric EV concepts. Equally important is the sufficient coverage of charging infrastructure to achieve the optimal ratio of EVs per charger. The ePowerMove concept is to develop a global energy-usage optimiser which brings together advanced technologies from charging infrastructure design and grid energy control, with a number of innovative and complementary elements to maximise the potential utilisation of individual innovations. All developments in the project are driven by social innovation, affordability and user acceptability, meeting users’ needs and requirements in socio-cultural contexts of different communities. The proposed slow charging solutions are cost-effective, bi-directional and interoperable, and intelligently synergised with the grid, to optimise the overall efficiency and capacity of power supply, mindful of increasing penetration of renewable energy systems. Solutions are demonstrated in Helsinki (Finland) with focus on charging infrastructure cost reduction and people-friendly applications, Klagenfurt (Austria) with focus on business model development and Nicosia (Cyprus) with focus on grid compatibility and energy flow optimisation. The multi-level systemic architecture is designed to be flexible, scalable, and compatible with a variety of regional power systems and V2G technologies. New business and usage models are explored to maximise the project results' impact, building up from a proven proliferation model developed in several EU-funded projects to assess policy intervention scenarios and strategies for mass-deployment EV uptake. ePowerMove will accelerate the transition to sustainable urban e-mobility and contribute to the reduction of greenhouse gas emissions in the global transport sector.

Keywords: electric car markets electric markets n electrification randd affordable ev concepts charging infrastructure epowermove bi directional optimizer grid social innovation user centric
Multivariate optoacoustic sensor for longitudinal diabetes monitoring (MOSAIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Spain,Greece,Austria,Italy
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 2997921.25
EU funding (EUR): 2997921.25
Participants: 6
Project status: SIGNED

MOSAIC will radically miniaturize non-invasive optoacoustic technology and make it portable by coupling optoacoustic sensing to novel explainable artificial Intelligence (xAI) to monitor a major health threat in the 21st century: Diabetes Mellitus. MOSAIC is based on recent advances on optoelectronic miniaturization and uses the skin as a window to dermal microvasculature and resolves a large number of biomarkers associated with diabetes. The technology is offered as a fast sensor that is inexpensive and reliable, entirely non-invasive and portable and supported by elaborate quality control monitoring so that it can be employed for long-term patient monitoring. Based on proof-of-concept human measurements, xAI will further independently characterize the predictive power of each biomarker and other clinical measurements to improve accuracy for continuous grading of disease status. Impact: With 537 million diabetics and a large at-risk population, MOSAIC potentially relates to 2B people and aims to reach more individuals than is practical to screen in medical facilities. It offers early diabetes detection for early interventions, as well as treatment monitoring, improving life expectancy, quality of life and reducing healthcare costs. Innovation: The sensor addresses 5 barriers to successful adoption: it is non-invasive, senses highly multiplexed biomarkers, it can be easily integrated into daily routine, and uses fully automated data-analytics. MOSAIC synergistically integrates 3 teams on sensor developments, data analytics and xAI, one preclinical and one clinical team for sensor validation in mice and humans, respectively, and an SME for exploitation.

Keywords: optoacoustic sensing,explainable ai,continuous monitoring,biomarkers,diabetes monitoring
Water Distribution Network Efficiency Optimisation with Resilience and Equity Quantification (WATER-RENEQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-21
End date: 2027-06-20
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 2
Project status: CLOSED

The proposal focuses on addressing critical challenges in water distribution networks (WDN), recognizing its fundamental role as an essential service for society. The WATER-RENEQ approach is a comprehensive methodology that optimizes WDNs by ensuring their response capacity to adverse events (resilience), guaranteeing equity for all users, and maximizing energy savings. The first objective (O1) aims to establish a set of quantifiable indicators and performance indices that measure the operation of WDNs. These indicators will encompass key aspects of resilience and equity while focusing on energy efficiency as a quantifiable metric. Objective two (O2) focuses on the development of an innovative mathematical model. This optimization model will calculate the indices defined in O1 within a WDN. It will provide a practical methodology to evaluate and analyze WDN resilience, addressing both operational aspects and overall system performance. The third objective (O3) targets advancements in the computational efficiency of optimization algorithms. This involves reducing the number of discrete variables and optimizing the overall search space. Improving computational efficiency is crucial for solving complex real-world optimization problems effectively. Objective four (O4) involves the development of an optimization tool that proposes investment strategies for WDNs. The tool's primary goal is to maximize resilience and equity indicators within the network, even when budget constraints are present. This approach aims to provide a robust mathematical framework that considers resilience and equity criteria. In summary, the proposal addresses fundamental challenges facing WDN by introducing an innovative approach to measure and improve resilience, equity, and energy efficiency, developing a computational tool that can be applied to real-world scenarios. Once the tool will be validated in a benchmarking network, this will be applied on a real WDN in a wáter supply company.

Keywords: water supply networks,resilience,equity,energy savings,sustainability,optimization models,evolutionary algorithms,search space reduction