Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Educating the next generation of professionals in the agrifood system (NEXTFOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Egypt,Italy,Italy,Ethiopia,Austria,Greece,Norway,Romania,Sweden,Sweden,France,Czechia,Czechia,Denmark,Denmark,Chile
Call: Building a future science and education system fit to deliver to practice (H2020-RUR-2017-2, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 7000000.0
EU funding (EUR): 7000000.0
Participants: 21
Project status: CLOSED

NEXTFOOD will drive the crucial transition to more sustainable and competitive agrifood and forestry systems development by designing and implementing education and training systems to prepare budding or already practicing professionals with competencies to push the green shift in our rapidly changing society. NEXTFOOD will challenge the linear view of knowledge transfer as a top-down process from research to advice and practice, and support the transition to more learner-centric, participatory, action-based and action-oriented education and learning in agrifood and forestry systems. In several pioneering case studies, covering agrifood and forestry systems in Europe, Asia and Africa, farmers solve real challenges related to sustainability together with researchers, students and other relevant stakeholders while developing both green technical skills and soft collaborative competencies. NEXTFOOD will assure quality in research and education by creating a peer-review system for evaluation of practice-oriented research outputs focusing on sustainability and practical usefulness. In addition, we will develop an international accreditation framework for education and training in fields relevant to sustainable agrifood and forestry systems. An innovative action research process will guide the NEXTFOOD project’s development in a cyclical manner, ensuring that the research process and actual case studies are ever-improving. This will exemplify how practice-oriented research can be instrumental to achieve: better collaboration between university and society, more innovation in the agrifood and forestry systems sector, and a progressive agrifood community ready to tackle complex sustainability challenges of the 21st century

Keywords: action learning,agricultural knowledge and innovation system,action research,case studies
A disruptive innovation improving functionality, increasing product life span and removing the need for tyre change through a patented modular tyre system. (reinventing the tyre)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-01-31
Duration (months): 16.0
Total project cost (EUR): 1074375.0
EU funding (EUR): 752062.5
Participants: 1
Project status: CLOSED

reTyre is a revolutionary tyre system allowing the user to easily adapt their tyres to their immediate needs, greatly improving their experience and safety. This is achieved through a patented technology where the tyre tread surface can be detached and subsequently changed. reTyre is the first to achieve a fully functional, user friendly and industrial and economically viable modular tyre system. Social and environmental benefits include reduced rubber consumption as only worn tread surfaces need to be discarded, and sustainable mobility is increased as adapting to road conditions is easier. reTyre have invested 3 years and a million euro in product development, production methods, established factory, distribution and organization to bring modular tyres to an international market for segments such as bicycles, scooters, motorcycles, wheelchairs and prams. A trial launch was undertaken in Norway (Oct-17), and a proof-of -concept is now available in 100+ retail stores. The next step for reTyre is to launch the complete modular tyre system for the more than 220 million bicycles and 6 million wheelchairs in the European market. The disruptive and patented technology has great functional benefits for the user, and represent a substantial reduction in rubber consumption for the tyre industry. reTyre is well suited for international scaling through implementation to multiple market segments. The modular system provides a great commercial opportunity through recurring sales and increased growth potential compared to conventional tyres. The entrepreneurial opportunity is further strengthened by a strong market growth (6% yearly) and a large market size (520 million bicycle tyres worldwide). Cycling is a key contributor towards achieving a sustainable urban environment for European cities. Large public investments and increased facilitation has resulted in a significant increase in cycling among European citizens, greatly benefiting the environment and public health

Keywords: biking,wheelchair,stroller,sustainable urban transport,sustainable tyre production,new market creation,improved mobility,scalable solution,international patent,international trademark
A lifelong transcatheter aortic valve prosthesis (TAVI4Life)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

Transcatheter aortic valve implantation (TAVI) techniques have revolutionized the therapy options for valvular heart disease. Initially developed for elderly high-risk patients, TAVI is being extended to younger patients and may become a first-line treatment in the near future. However, the available bioprostheses for TAVI are prone to degeneration, and patients may thus require multiple re-interventions, significantly affecting their life quality. To date, a native-analogous TAVI prosthesis with in-situ remodeling capacity does not exist. Tissue engineered (TE) heart valves represent a potential solution, but are not yet suitable for high-pressure applications and lack clinical translation because of uncontrolled in-vivo remodeling, impairing their long-term functionality. In the TAVI4Life project, I aim to develop and validate a novel TAVI prosthesis for young patients with the unique ability to transform into a fully autologous valve within the body and last for life. This project will go far beyond previous TE concepts by engineering a novel decellularized human ECM and a bioresorbable stent and applying an unconventional bioengineering approach combining in-vitro, in-silico, and in-vivo TE methods. First, I will engineer and characterize a clinical-grade ECM for high-pressure conditions and test patient-specific immuno- and hemocompatibility profile (in-vitro). Next, using computational modeling, I will design and develop a bioresorbable stent and implement an analytical valve design to develop the transcatheter prosthesis (in-silico). Finally, I will evaluate valve performance and remodeling in a preclinical large animal model (in-vivo). This highly multidisciplinary approach will lead to a valve prosthesis that lasts for life, as guided in-situ tissue remodeling will enable their long-term performance. The clinical impact will be enormous as, particularly for young patients, the TAVI4Life will significantly enhance their life expectancy and quality of life.

Keywords: heart valve disease,tissue engineering,biomedical engineering,tavi,bioresorbable stent,computational modelling,in vitro in situ,in vivo
LIFE LAB - Connecting Communities with the UK's leading Biotechnology and Life Science Hub (LIFE LAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 351091.9
EU funding (EUR): 158520.0
Participants: 5
Project status: CLOSED

LIFE LAB will bring researchers and publics together by drawing on the excellence of the UK’s premier region for life science research in and around Cambridge and East England . Our proposal name is inspired by those journeys from research to real-world applications that impact on people’s lives and by the notion of bringing our respective LABs to LIFE. LIFE LAB will host a compelling programme of researcher-led events in Cambridge and surrounding towns on 28 Sept 2018 and 27 Sept 2019. A primary aim of LIFE LAB is to engage communities (schools and public) not traditionally connecting with the ‘Cambridge phenomenon’ and for whom this research powerhouse on their doorstep presents real opportunity in terms highlighting the impact of research on their daily lives and promoting new career pathways to study and work. Our LIFE LAB team represents a group of world-leading research organisations with a unique story to share. This builds on centuries of history and achievement, ground-breaking discoveries (including the structure of DNA and the Human Genome) and present-day frontier research and innovation. LIFE LAB will connect researchers and the general public across the UK’s leading eco-system for life sciences while celebrating the European Year of Cultural Heritage in 2018 by casting a spotlight on science - past, present and future – as an important part of culture. LIFE LAB will be immersive - promoting hands-on approaches and involving people in research through the Nights; especially early stage research where dialogue and airing of views could bring alternative perspectives. LIFE LAB will build on partnership developed across the public engagement and education professionals in our consortium to extend reach into the region’s schools and teacher networks. Lastly, but importantly, LIFE LAB will showcase the importance of collaboration, freedom of mobility and respect of shared knowledge and values – particularly important at a time of change.

Keywords: life science,genomics,molecular biology,night,european researchers night,public engagement,microbiology,biotechnology
Tubular Supramolecular Polymer Brushes as Novel Therapeutic Materials (TSPBNTM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The aim of this project is to develop supramolecular polymer brushes through the self-assembly of cyclic peptide/polymer conjugates into functional materials for applications as therapeutic polymers. The research program is articulated around 1/the fabrication of supramolecular polymers of precisely controlled structures from peptide–polymer conjugate synthesis to self-assembly and 2/applying these supramolecular polymers to build delivery vehicles for therapeutic applications.

Keywords: cyclic peptides,supramolecular polymer brushes,self assembly,drug delivery
A synthetic biology approach for magnetization of foreign organisms by genetic engineering and transplantation of bacterial magnetosome biosynthesis (SYNTOMAGX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2291875.0
EU funding (EUR): 2291875.0
Participants: 1
Project status: CLOSED

An immensely valuable asset to the field of synthetic biology would be a means to genetically endow magnetism to living organisms, which is still an unsolved challenge due to the lack of appropriate tools. In contrast, biomagnetism is innate to magnetotactic bacteria, mud-dwelling microbes which as geomagnetic sensors biomineralize iron nanocrystals with exceptional properties, the magnetosomes. However, transplantation of magnetosome biosynthesis has remained unachieved for many years, owing to its complexity and lack of knowledge of genetic determinants. Recently, my lab discovered relevant biosynthetic gene clusters and for the first time succeeded in expressing them in a foreign bacterium. Inspired by this major breakthrough, I now propose a step change approach for endogenous magnetization of diverse organisms based on bacterial magnetosome biosynthesis. By combining systematic genetic reduction with bottom-up redesign we will first minimize the pathway to make it universally portable. We will then reprogram E. coli into a chassis for plug-in expression of diverse magnetosome gene sets. By harnessing determinants of structurally diverse magnetosomes from various bacteria, we will reconfigure the pathway for mix-and-match generation of designer nanoparticles with tuned magnetic properties. Finally, we will attempt to reconstitute key parts of magnetosome formation in eukaryotic hosts by using yeast mitochondria as a universal model. The overall aim is to generate a versatile synthetic toolkit for genetic magnetization of different organisms. This would represent a quantum leap with tremendous impact on various fields of biomedical research and biotechnology. It might be exploited for bioproduction of tailored magnetic nanomaterials with novel and tunable properties. It could be further utilized to generate intracellular labels, tracers and actuators for magnetic manipulation and analysis of cells and organisms in the emerging field of magnetogenetics.

Keywords: magnetosomes,magnetotactic bacteria,magnetic nanoparticles,biomineralization
Mobile phone as a Key - A new access ecosystem for 112, service companies and citizens “Key Cloud” (Key Cloud)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Key Cloud project focuses on development a solution that takes physical keys to buildings to a mobile phone and cloud and is applicable across the EU. Lukoton Experience Oy provides a solution, which allows mobile phones to be used as virtual keys to open traditional mechanical locks at a very low incremental cost. The innovation, that includes software and lock controller product, has already been verified to generate considerable savings and CO2 reductions in Home Care business in Finland. The main goal now is to leverage on this innovation and develop an EU-compatible mobile locking solution and novel business model: the “Key Cloud”. It will expand our business to new markets and customer segments. We are targeting to take 0.5% share from 10 billion € global markets in 2020. The virtual key in the cloud allows access rights to be sold as a service and makes them traceable with log data. Field force service personnel can thus operate without the burden of finding, carrying, storing or returning physical keys or other access media. The first users are 112 Emergency Operators and different service companies who need a standard and flexible accessing scheme for all buildings. Next user group is facility managers who take care of the key logistics and access rights. In order to reach our target quickly, we need to realize a feasibility study to understand EU markets and potential partners, key players, local characteristics in selected countries and entry barriers in order to optimize our offering and business model (Phase 1). Second (Phase 2), we need to build the necessary capabilities (technology and business) to meet the needs in the selected markets and for selected customers. The overall solution will reduce CO2 emissions and enable the field service organizations to optimize their use of resources. In the future, the solution will be modified to cater for the needs of individual citizens on their home doors, and expanded to global consumer markets.

Keywords: electronic access control,mobility,cloud,emergency access
Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development (EPIROSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 2477951.0
EU funding (EUR): 2477951.0
Participants: 1
Project status: CLOSED

Embryonic development progresses through successive cell fate decisions and intricate three-dimensional morphogenetic transformations. Implantation is the defining event in mammalian pregnancy during which a fundamental morphogenetic transformation is initiated: the body axes are established and the embryonic germ layers created. Despite its importance, a comprehensive understanding of the molecular mechanisms, transcriptional pathways, cellular interactions, as well as the spatio-temporal development of the embryo at implantation stages is at present lacking, due to the embryo’s inaccessibility. To overcome these limitations, we generated a culture system that allows the development of mouse implanting embryos outside of the mother. This system provides the opportunity to address how architectural features and signaling events integrate to induce the emergence of the body plan. Combining this new technology with the analysis of genetically engineered mouse embryos, the aim of this research proposal is to fill the knowledge gap between pre and post-implantation development. Single cell sequencing, two-photon microscopy, high-content forward genetic screening, and modeling will be merged with a functional assessment of embryo development in vivo to reveal the determinants of implantation and early post-implantation development. This global understanding will be employed to explore the extent to which stem cells can recapitulate embryonic development, with tremendous potential for regenerative medicine. Knowledge of the cellular and molecular mechanisms that intertwine lineage specification, developmental potential, and tissue morphogenesis will offer novel insight on the pathological causes of embryo lethality and congenital disorders. The proposed studies will shed light on this crucial yet mysterious stage of development in the mouse and, by extrapolation, offer outstanding potential to advance our understanding of human development.

Keywords: rosette,epiblast,cell differentiation,morphogenesis
Sonorous Cities: Towards a Sonic Urbanism (SONCITIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999825.0
EU funding (EUR): 1999825.0
Participants: 1
Project status: SIGNED

Architecture and urban design, disciplines heavily rooted in visual epistemologies, have long neglected sound, or else treated it in very limited ways: as a physical quantity that can be modelled and controlled; or else as noise, something to be reduced or eliminated. The neglect of sound on the part of the built environment professions has been damaging for cities, which suffer from poor acoustic design. As cities come under increasing scrutiny in a rapidly urbanising world, it is time to turn attention to one of the most pervasive—yet most neglected—aspects of urban life: how cities sound; how the experience of urban soundscapes is differentiated along social and cultural lines; and how to harness the creative potential of sound to build healthier, more inclusive, more sustainable cities. SONCITIES will bring together sound theorists, urban sociologists, architects, urban designers and sound artists to develop the conceptual framework of sonic urbanism: a new acoustic paradigm for cities. First, we will conduct unprecedented ethnographic research with urban residents and communities, aiming to discover how people experience and shape urban soundscapes in their everyday lives. On this basis we will form a mobile urban sound laboratory to generate new sonic modes of urban analysis in dialogue with built environment practitioners internationally. Finally, we will develop new sonic modes of urban design in the context of Design Weeks, public exhibitions, and creative sonic interventions in cities: projects that will serve as prototypes for sonic urbanism. SONCITIES is led by a sound theorist and sound art practitioner at Oxford University with a proven record of collaboration with architects and urbanists. Through SONCITIES, sound will be placed at the forefront of creative practice in architecture and urban design, and sonic urbanism will emerge as an innovative theoretical paradigm that fundamentally transforms how cities are understood, designed and experienced.

Keywords: sound studies,sound in architecture and urban design,urban sound,sound art,sound and environment,urban sociology