Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Voluntary certification scheme for waste treatment (CEWASTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Coordination and support actions
Countries involved: Austria,Italy,Ireland,Italy,Germany,Spain,Belgium,Switzerland,Switzerland,Finland,Switzerland,Netherlands,Netherlands,Portugal,Japan,United Kingdom
Call: Raw materials policy support actions for the circular economy (H2020-SC5-2018-1, 2018)
Start date: 2018-11-01
End date: 2021-04-30
Duration (months): 30.0
Total project cost (EUR): 1924717.5
EU funding (EUR): 1924717.5
Participants: 20
Project status: CLOSED

The CEWASTE project contributes to an improved recovery of valuable and critical raw materials (CRMs) from key types of waste through traceable and sustainable treatment processes in the entire supply chain of secondary raw materials. As such, CEWASTE will address the specific challenge to secure the sustainable access to CRMs for the EU economy and objectives set by the EU action plan for the Circular Economy, the issue of illegal trade of wastes within the EU and to non-EU countries and the need to support the development of environmentally and socially sound recycling systems globally. Specifically, the project will develop, validate and launch a voluntary certification scheme for collection, transport and treatment facilities of key types of waste containing significant amounts of valuable and critical raw materials. To ensure a comprehensive approach and a robust result, the project will be developed along the following six specific objectives: Objective 1 - Understand existing recovery practice, standards and verification schemes; Objective 2 - Develop sustainability and traceability requirements; Objective 3 - Develop an assurance system and related verification procedures; Objective 4 - Validate the new voluntary scheme; Objective 5 - Ensure long term sustainability of the scheme; Objective 6 - Ensure a transparent stakeholder process.
Unexpected connections between a phagocytic machinery and mammalian fertilization (Sperm-Egg Phusion)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2499375.0
EU funding (EUR): 2499375.0
Participants: 1
Project status: SIGNED

Fertilization is essential for a species to survive. Mammalian sexual reproduction requires the fusion between the haploid gametes sperm and egg to create a new diploid organism. Although fertilization has been studied for decades, and despite the remarkable recent discoveries of Izumo (on sperm) and Juno (on oocytes) as a critical ligand:receptor pair, due to the structure of Izumo and Juno, it is clear that other players on both the sperm and the oocytes must be involved. While the focus of our laboratory over the years has been in understanding apoptotic cell clearance by phagocytes, we accidentally noted that viable, motile, and fertilization-competent sperm exposes phosphatidylserine (PtdSer). PtdSer is a phospholipid normally exposed during apoptosis and functions as an ‘eat-me’ signal for phagocytosis. Further, masking this PtdSer on sperm inhibits fertilization in vitro. Based on additional exciting preliminary data, in this ERC proposal, we will test the hypothesis that PtdSer on viable sperm and the complementary PtdSer receptors on oocytes are key players in mammalian fertilization. We will test this at a molecular, biochemical, cellular, functional, and genetic level. From the sperm perspective — we will ask how does PtdSer changes during sperm maturation, and what molecular mechanisms regulate the exposure of PtdSer on viable sperm. From the oocyte perspective — we will test the genetic relevance of different PtdSer receptors in fertilization. From the PtdSer perspective — we will test PtdSer induces novel signals within oocytes. By combining the tools and knowledge from field of phagocytosis with tools from spermatogenesis/fertilization, this proposal integrates fields that normally do not intersect. In summary, we believe that these studies are innovative, timely, and will identify new players involved in mammalian fertilization. We expect the results of these studies to have high relevance to both male and female reproductive health and fertility.

Keywords: phosphatidylserine,phagocytosis,efferocytosis,phagocytic receptors,ptdser receptors,apoptosis,bai1,cd36,elmo,cytoskeletal reorganization,myoblast fusion,bai3,cell fusion
dEsign enVironmEnt foR Extreme-Scale big data analytics on heterogeneous platforms (EVEREST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Switzerland,Slovakia,Switzerland,France,France,Czechia
Call: Big Data technologies and extreme-scale analytics (H2020-ICT-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 5037372.5
EU funding (EUR): 5037372.5
Participants: 10
Project status: SIGNED

The distributed and heterogeneous nature of the data sources in High Performance Big Data Analytics (HPDA) applications, as well as the required computational power, is pushing designers towards novel computing systems that combine HPC, Cloud, and IoT solutions (for efficient and distributed computation closer to the data) with Artificial Intelligence (AI) algorithms (for knowledge extraction and decision making). In this context, the EVEREST project addresses the matching problem between application (and data) requirements, and the characteristics of the underlying heterogeneous hardware. Only an optimal match leads to efficient computation. In particular, we forecast that the creation of future Big Data systems will be of course data-driven, but also featuring complex heterogeneous and reconfigurable architectures that must be redesigned or customized based on the nature and locality of the data, and the type of learning/decisions to be performed. The EVEREST project aims at developing a holistic approach for co-designing computation and communication in a heterogeneous, distributed, scalable and secure system for HPDA. This is achieved by simplifying the programmability of heterogeneous and distributed architectures through a “data-driven” design approach, the use of hardware-accelerated AI, and through an efficient monitoring of the execution with a unified hardware/software paradigm. EVEREST proposes a design environment that combines state-of-the-art, stable programming models, and emerging communication standards, with novel and dedicated domain-specific extensions. Three industry-relevant application scenarios are used to validate the EVEREST approach and act as business cases for the project exploitation: (i) a weather analysis-based prediction model for the renewable energy trading market, (ii) an application for air-quality monitoring of industrial sites, and (iii) a real-time traffic modeling framework for intelligent transportation in smart cities.

Keywords: heterogeneous architectures,programmability,domain specific languages,artificial intelligence,high level synthesis,distributed systems
The innovative heat pump boiler to double energy efficiency in heat generation (APACHE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-02-28
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heating today is responsible for 50% of the EU's annual energy consumption. However, a large part of this energy is wasted because almost half of the EU's buildings have boilers installed before 1992, with an efficiency rate of below 60%. Transition has started with the deployment of regulatory measures (Energy Efficiency Directive, Building Energy Efficiency Directive, Energy Labelling Directive, national building codes…) and the prospect of substantial savings in heating and hot water expenses. boostHEAT is positioned right at the front of this transition towards energy efficiency. The company has developed a new generation of boilers, heat pump boilers, that use the heat pump effect to reduce by 50% energy consumption and greenhouse gas emissions. At the core of this achievement is a novel thermodynamic compressor, which is used to increase the efficiency of the heating cycle. Performance of the Apache boiler can double that of condensing boilers and is competitive with the most efficient electric heat pumps boostHEAT was founded in 2011 in France. Early on, they received the interest of high profile industry participants. GRDF (main natural gas distribution company in France) and Dalkia (leader in energy services) amongst others. Today boostHEAT employs 32 professionals (of which 22 are engineers), has filled 5 patents all around the word and raised over €4.5 million in private capital. boostHEAT ambition is to progressively become an industrial group. We have reached an agreement with the industrial group Bosch to progressively develop our manufacturing operations at their site in Vénissieux, providing a regeneration opportunity to the declined activity of the factory. The goal of the Apache project is to bring the Apache boilers (20kW) to a state of serial production and commercialization, that will enable the most efficient heating systems to be installed in renovations of individual homes.

Keywords: building energy efficiency,high efficient heating technology,boiler,heat pump
Seafarm Pulse Guard (SPG)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Norway
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 2516250.0
EU funding (EUR): 1761375.0
Participants: 1
Project status: CLOSED

SPG will mature and validate a unique, chemical-free, and cost-effective technology preventing sea lice infestation in salmon farms and contributing to a more sustainable parasite control, with no additional environmental impact. Our patented technology (Seafarm Pulse Guard, WO 2014054951 A1 and NO 334396 B1) uses electrical pulses to inactivate pelagic stages of crustacean parasites (Nauplius/Copepodites) before they attach to the fish, stopping infestation within the cage and further spreading in the surrounding environment. SPG effectively reduces sea lice infestation by up to 90%, biofouling by 90% and attenuates the risk of escape in 20%, cutting sea lice treatment costs from current €0.3-0.9 to €0.1-0.2 per kg of fish produced. Being compliant with the strictest fish welfare standards, SPG brings fish farmers more predictable revenue streams, and a reduction in overall operational costs of min. 20%. Upon successful completion of this Phase II project, SPG will be the only preventive method in the market that also reduces infection spreading in the marine ecosystem, increasing the sustainability of existing sea salmon farming sites and opening new opportunities for expansion and access to new areas. We have already signed commercial agreements with Marine Harvest ASA and Lerøy Vest allowing us to start the commercialisation of our SPG solution immediately after SPG project closure. By the end of 2023 (5 years post-project) we estimate to have reached an accumulated revenue of €84.3m, generated at least 27 new full-time positions, and accumulated profits of €41.7m. We have completed the development of the SPG’s sub-system technologies and prototypes to TRL7. Now the technology can be integrated and assembled into a functional system at TRL8, with necessary adaptation and optimisation, ready for subsequent validation in a large-scale real-life environment (TRL9).

Keywords: sea lice,parasite control,atlantic salmon,preventive method,fish health,sustainable,aquaculture,chemical free,fish welfare
Pan-European Network of Customs Practitioners (PEN-CP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Germany,Albania,Austria,Estonia,Ireland,Switzerland,North Macedonia,Norway,Belgium,Hungary,Lithuania,Slovakia,Latvia,France,Netherlands,Netherlands,United Kingdom
Call: Pan European Networks of practitioners and other actors in the field of security (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-09-01
End date: 2025-01-31
Duration (months): 77.0
Total project cost (EUR): 3496253.13
EU funding (EUR): 3496253.13
Participants: 18
Project status: SIGNED

PEN-CP, the Pan-European Network of Customs Practitioners – EU Horizon 2020 funded Customs security practitioner project – acts as a European Customs innovation boosting network, powered by an innovation-centric online platform, and tailored innovation intermediary services. Since the start of the project (Sep.2018), the project consortium includes the following 13 administrations as full partners (9 EU and 4 non-EU): ALB, AUT, BEL, EST, GBR, HUN, IRL, LTU, LVA, NLD, MKD, NOR & SVK. PEN-CP focuses on accelerating innovation efforts across three core Customs technical areas: Data and risk management; Detection technologies; and Laboratory equipment. We have a broad variety of innovation and knowledge instruments in use, including Technology grants, Challenge competitions, Innovation awards, Annual studies and Expert reports. Across our activities, we aim to connect innovation-spirited Customs officers, helping them to ‘find friends in Customs innovation’. The vision is to become a permanent Customs innovation boosting network, helping to accelerate both incremental and radical innovations, for the benefit of Customs administrations in Europe and beyond.

Keywords: customs security,co development,innovation,organised crime,supply chain security
Conversion of natural plant nanovesicles into nutraceutical delivery system (nanoTOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Novel encapsulation approaches to create alternative delivery options for nutraceuticals are emerging as a promising strategy to enhance the bioavailability of poorly absorbed active food ingredients. In this context, nanoTOM aims to exploit edible plant derived nanovesicles and use them as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. Plant cells secret phospholipid membrane-surrounded vesicles morphologically similar to mammalian extracellular vesicles. Exploitation of plant nanovesicles is promising although hampered by i) their difficult isolation and ii) the lack of knowledge of their biogenesis, molecular architecture, uptake and biological effects. The experienced researcher is a chemist with strong academic and pharmaceutical background in the isolation and analysis of bioactive compounds from medicinal plants who team-up with the Institute of Biosciences and BioResources (IBBR) with considerable expertise in extracellular vesicle research to realize a uniquely interdisciplinary research program. The research proposed here will realize the following concrete objectives: 1. Set-up an integrated analytical pipeline for the isolation, characterization, encapsulation, uptake and toxicological profiling of plant nanovesicles. 2. Use the pipeline to exploit different Solanum lycopersicum (tomato) nanovesicle populations regarding secretion mechanism, heterogeneity, biocargo composition, nutraceutical and encapsulation properties. Neither of these objectives have been addressed before and both have high potential to expand the knowledge in the field and to drive the research activity towards industrialization. The research objectives are integrated with concerted training objectives in plant, cellular and molecular biology and omics, outreach program, dissemination events and considerable knowledge transfer in the isolation and use of herbal nutraceuticals from the researcher to the IBBR host group.

Keywords: nutraceuticals,tomato,nanovesicles,extracellular vesicles,secretion mechanisms,biochemistry,physical and analytical chemistry,encapsulation,proteomics,metabolomics,lipidomics,c elegans
Recovery and Return-To-Base European Reusable Micro-Launcher Project (RRTB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Spain,Belgium,Greece,Czechia
Call: Access to space (H2020-SPACE-2019, 2019)
Start date: 2020-02-01
End date: 2023-04-30
Duration (months): 39.0
Total project cost (EUR): 3082740.0
EU funding (EUR): 3082740.0
Participants: 8
Project status: SIGNED

The rise of small satellites and large constellations is changing the satellite industry. Due to the growth of the small satellite market, launch has become the bottleneck of the industry. According to MT Aerospace the micro-launcher market will grow as much as four to seven times in the next decade, with a full market potential of up to €7B. The RRTB consortium believes that a tailored service for access to space for small satellites is required. However, micro-launchers regularly have higher launch costs per kilogram than bigger launchers. Today, the cornerstone of this emerging market is the economic viability of launching small payloads at high frequencies to dedicated orbits. According to the RRTB consortium, technological development and vehicle reuse are fundamental steps to bring down the cost of launch and access-to-space. This project investigates the recovery and return to base system (RRTB) for the first stage of the MESO launch vehicle. The recovery and return to base system is divided into two parts: 1. Passive atmospheric reentry: The atmospheric reentry of the first stage of the vehicle will be a passive reentry. During the project this phase, together with its required hardware, will be investigated and defined during the project by Pangea Aerospace together with Deimos Space and VKI. 2. Horizontal landing: Landing of the first stage of the vehicle is intended to be performed using a novel patent pending horizontal landing technology that uses electric ducted fans situated in both sides of the first stage of the launch vehicle to brake the fall of first stage, control it and perform a safe landing. This phase will be studied by TUM and Pangea Aerospace. Furthermore during the project the structural design and analysis of the MESO launch vehicle, as well as an investigation of the launch vehicle's propellant tanks (a critical component for cost-efficient reuse), will be performed. This work will involve RWTH, Heron, TAS, Toseda and Pangea.

Keywords: reusable launch vehicle micro launcher recovery european access to space cost novel landing reentry
A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE (BREEDIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-08-31
Duration (months): 72.0
Total project cost (EUR): 2474790.0
EU funding (EUR): 2474790.0
Participants: 1
Project status: SIGNED

Feeding the growing world population under changing climate conditions poses an unprecedented challenge on global agriculture and our current pace to breed new high yielding crop varieties is too low to face the imminent threats on food security. This ERC project proposes a novel crossing scheme that allows for an expeditious evaluation of combinations of potential yield contributing alleles by unifying ‘classical’ breeding with gene-centric molecular biology. The acronym BREEDIT, a word fusion of breeding and editing, reflects the basic concept of combining breeding with multiplex genome editing of yield related genes. By introducing plants with distinct combinations of genome edited mutations in more than 80 known yield related genes into a crossing scheme, the combinatorial effect of these mutations on plant growth and yield will be evaluated. Subsequent rounds of crossings will increase the number of stacked gene-edits per plant, thus increasing the combinatorial complexity. Phenotypic evaluations throughout plant development will be done on our in-house automated image-analysis based phenotyping platform. The nature and frequency of Cas9-mediated mutations in the entire plant collection will be characterised by multiplex amplicon sequencing to follow the efficiency of CRISPR-cas9 genome editing and to identify the underlying combinations of genes that cause beneficial phenotypes (genetic gain). The obtained knowledge on yield regulatory networks can be directly implemented into current molecular breeding programs and the project will provide the basis to develop targeted breeding schemes implementing the optimal combinations of beneficial alleles into elite material. BREEDIT will be a major step forward in integrating basic knowledge on genes with plant breeding and has the potential to provoke a paradigm shift in improving crop yield.

Keywords: plant breeding,genome editing,yield genes,maize