Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrasensitive Chirped-Pulse Fourier Transform mm-Wave Detection of Transient Species in Uniform Supersonic Flows for Reaction Kinetics Studies under Extreme Conditions (CRESUCHIRP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2100230.0
EU funding (EUR): 2100230.0
Participants: 1
Project status: CLOSED

This proposal aims to develop a combination of a chirped-pulse (sub)mm-wave rotational spectrometer with uniform supersonic flows generated by expansion of gases through Laval nozzles and apply it to problems at the frontiers of reaction kinetics. The CRESU (Reaction Kinetics in Uniform Supersonic Flow) technique, combined with laser photochemical methods, has been applied with great success to perform research in gas-phase chemical kinetics at low temperatures, of particular interest for astrochemistry and cold planetary atmospheres. Recently, the PI has been involved in the development of a new combination of the revolutionary chirped pulse broadband rotational spectroscopy technique invented by B. Pate and co-workers with a novel pulsed CRESU, which we have called Chirped Pulse in Uniform Flow (CPUF). Rotational cooling by frequent collisions with cold buffer gas in the CRESU flow at ca. 20 K drastically increases the sensitivity of the technique, making broadband rotational spectroscopy suitable for detecting a wide range of transient species, such as photodissociation or reaction products. We propose to exploit the exceptional quality of the Rennes CRESU flows to build an improved CPUF instrument (only the second worldwide), and use it for the quantitative determination of product branching ratios in elementary chemical reactions over a wide temperature range (data which are sorely lacking as input to models of gas-phase chemical environments), as well as the detection of reactive intermediates and the testing of modern reaction kinetics theory. Low temperature reactions will be initially targeted; as it is here that there is the greatest need for data. A challenging development of the technique towards the study of high temperature reactions is also proposed, exploiting existing expertise in high enthalpy sources.

Keywords: gas kinetics,low temperature rate constants,experimental astrochemistry,fundamental reaction kinetics,product branching ratios,elementary reactions
ZEP15 (ZEP15)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Belgium,Netherlands
Call: Energy 75 per cent reimbursement (H2020-Adhoc-2014-20, 2015)
Start date: 2015-07-20
End date: 2015-12-19
Duration (months): 5.0
Total project cost (EUR): 160000.0
EU funding (EUR): 120000.0
Participants: 2
Project status: CLOSED

The objective of the ZEP15 proposal is to provide support to the development and communication of policy messages of the European CCS community (represented by European Technology Platform ZEP (ETP-ZEP)). Support will be given to the internal organizational and administrative processes within ZEP in order to enable ZEP to carry out activities that are beneficial to the European CCS community, as well as to externally oriented communications activities for bringing the messages of ZEP to the European CCS community.

Keywords: ccs zep carbon capture and storage
Double face foldable composite material for disruptive applications – MADly strong, Super FLEX (MadFlex)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Composite Sandwiches are a special class of composite materials combining structural performance to lightweight, which are increasingly used in aerospace, building, automotive, sport and leisure sectors, with an estimated CAGR of 8% in the next 5 years. One of the drawbacks consist in their stiffness and difficulty in joining together different parts, which imply the need to produce monolithic components, increasing enormously costs and complexity of realization, transport and mounting. CoRe has developed and patented MadFlex: an innovative composite sandwich design and production process, which makes the panel flexible (even rollable) on the one side and rigid/crushproof on the other, at comparable cost and using the same production facilities. MadFlex can replace standard composites in different sectors where flexibility can be a keystone to simplify storage, transport and mounting or can substitute flexible polymeric materials adding structural performance to lightness. In the aerospace sector CoRe is collaborating with Arescosmo and ESA for the development of rigid foldable structures for satellites; Leonardo and Airbus for producing fuselage and wings elements for aircrafts. The strategy to get to the market is to involve composite manufacturers under a license agreements for specific applications. The Serviceable Available Market (SAM) in the building, aerospace, transportation and sport /healthcare is estimated of 323 M€/y of which MadFlex could take >100 M€/y in 5 years through a portfolio of 14 applications. This will correspond to royalties for CoRe of 6.7 MEuro and EBIT of 5M€ (75% margin). The objectives of the feasibility study are: 1) Validate the technical feasibility and definition of 2 use cases in Aerospace and Architecture for demonstration in phase 2 project. 2) Define an agreement with 1 manufacturer; 3) Refine the Business Plan and Implementation Plan to reach the market; profiling and identification of VC to support the upscale.

Keywords: flexible composites sandwich,fiber reinforced polymers,lightweighting,aerospace,automotive,architecture
KerecisTM Omega3 Wound: the first fish skin substitute in the European Market for chronic wound care (Kerefish)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Italy,Iceland,Sweden,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-11-01
End date: 2023-08-31
Duration (months): 46.0
Total project cost (EUR): 3741044.25
EU funding (EUR): 2995417.43
Participants: 4
Project status: SIGNED

Chronic wounds in general and diabetic foot ulcers (DFU) in particular are a challenge to wound care specialists and health care systems. With 8.5% of the global population suffering from diabetes, diabetic foot disease results in costs of about €4.1bn yearly in Europe alone. Patients find their quality of life seriously affected and, in many cases, DFU leads to amputation. Standard treatment for chronic wounds today is moist wound healing with standard wound dressings. Lately, efforts have been made to introduce novel, advanced treatment options, such as skin grafts from mammalian tissue and growth factors. However, none of these has been able to provide solid evidence for clinical efficacy and cost-effectiveness, and they are not available through public health care systems in Europe. Kerecis (Iceland), the coordinator of the Kerefish project, has developed KerecisTM Omega3 Wound, a novel skin substitute derived from North Atlantic cod skin. The unique structure of the grafts and their high content of Omega 3 fatty acids promote wound healing, even in severe DFU cases. KerecisTM Omega3 Wound has received the CE mark and FDA approval. However, as it is currently not reimbursed by public health systems in Europe, it is not yet available for the European population. Kerecis has teamed up with CERITD (France), an association for diabetes prevention and treatment and Endospin (Italy), a distributor of wound care products with experience in clinical trial sponsoring, to carry out large-scale clinical trials in 4 European countries and prepare the path to reimbursement and to the European health care market for this disruptive product, which will improve patients quality of life and help solve one of the pressing health problems of today’s societies. The Kerefish project will accumulate €70M of revenues and €18M of EBITDA in the first 5 years of commercialization.

Keywords: wound care,chronic wounds,diabetic foot ulcers,skin substitutes,fish skin
Robotic Synthesis Farm (RoboSynFarm)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Lithuania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scientists in academia and industry who perform R&D in nature and life sciences are facing problems related with commercially availability of synthetic novel compounds. UAB SynHet novel RoboSynFarm approach addresses the disruptive and innovative solution for broader sustainable synthetic compounds accessibility targeted customer demand with significant impact not only on the final, more affordable synthetic product price but also on lower energy consumption and greener environmental impact.

Keywords: organic chemistry,organic synthesis,farm,machine learning,neural network
Fast and Nanoscale Spin Control via Single Flux Quanta in Superconductors (FastoSpintrolux)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-14
End date: 2022-10-13
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Quantum control of spin qubit plays a key role in spintronics, quantum sensing and quantum information processing. The spin control rate determines the quantum state fidelity and the accuracy in quantum sensing, and thus needs to be enhanced for many applications. Meanwhile, building scalable quantum technology often involves densely distributed qubits, which requires the feasibility of addressing individual spins with high spatial resolution. In order to cope with the growing demand for the operational rate and spatial precision, the experienced researcher proposes to use single flux quanta (Abrikosov vortices) in superconductors to individually address the electronic spin of nitrogen-vacancy (NV) centers with far-field optics. Optical manipulation of single vortices like optical tweezers enable the nanoscale addressability of individual spins. By rapidly passing a vortex and its strong field through the spin target, he aims at swiftly tuning the spin resonance and coherently driving spin transitions with gigahertz rate. This proposal opens new possibilities of exploring the coupling between mesoscopic flux quanta and single qubits, and provides a promising method for efficiently entangling multiple spins via optically driven Abrikosov vortices.

Keywords: spin qubit,coherent control,diamond nv centers,flux quanta,superconductor,electron spin resonance,abrikosov vortices,optical manipulation
Reg-X310: new disruptive medicine for faster exit from aplasia afetr agressive chemotherapy of hematologic malignancies (ExitAplasia)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe; a significant portion is treated by chemotherapy, which triggers the destruction of red and white blood cells: aplasia. This aggressive treatment results in a severe deficient immunity and an extremely fragile health, which causes patients with leukaemia, for example, to stay 21 days at the hospital in a sterile room costing in average €25,000 per day. In this extremely difficult situation, RegStem has found the high-potential solution: the new Reg-X310 medicine which allows faster red and white blood cells regeneration, accelerating exit from aplasia and shortening hospital length of stay of at least 4 days. It is a tremendous improvement in relation to only existing medicine that speeds out aplasia for only one day. This breakthrough innovation will speed up recovery, decrease the risk of dying from a hospital-acquired infection (~7% less), and decrease healthcare cost for around €100,000/patient. Reg-X310 is a game-changing innovation which will substantially improve the treatment of aplasia and disrupt the market. Reg-X310 is being developed by RegStem, a French awarded innovative company, founded as a spin-off of the world-famous Pasteur Institute in Paris. The ExitAplasia project will allow the company to reformulate the Reg-X310 into an intravenous injection and to start the toxicological and clinical validation as well as the CE marking, necessary for the commercialisation in Europe. To accomplish this goal, RegStem will complete a feasibility study to further analyse users’ pain points and actual trends, as well as broaden European key stakeholder networks and explore new business opportunity. RegStem will lead the European and global acute leukaemia market with 10% market share in 2023 and up to 70% before 2027, which will result in €14 and €99 million turnover, and more than 20 new European jobs

Keywords: aplasia,drug repurposing,drug discovery,bone marrow,regenerative medicine,chemotherapy,leukaemia,lymphoma,health,hospitalisation
Early Stage Investing Launchpad - Unleashing the potential of early stage investing in Europe (ESIL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Access to risk finance
Action type: Coordination and support actions
Countries involved: Italy,Malta,Belgium,France,United Kingdom
Call: Awareness-raising and capacity-building for business angels and other early-stage investors (H2020-CBBA-2016-1-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 2493300.0
EU funding (EUR): 2493300.0
Participants: 7
Project status: CLOSED

ESIL will establish an EU Framework for capacity building for early-stage investors in Europe, facilitating the take up of Angel Investing, overcoming obstacles related to market outreach and engaging key actors e.g. entrepreneurs, unconventional early stage investors and crowdfunding. To maximise impact ESIL will deliver dedicated actions, tools and mobilise expertise for every investor at any given stage of his/her experience, from awareness to actual investment to "bring on board” local and international investment capacities, increasing the conversion rate in the journey from the awareness raising to the actual investments ESIL will use state of the art on line material and best in class technology platform, but at the same time will engage top Business Angels in intimate events with local champions boosting the process in an informal, peer2peer fashion especially in countries with a younger Angel market The potential is huge, even if we want to count on the most optimistic estimates of 250k business angels today active in Europe this is still far from e.g. the 3mln HWNI Europe can count on ESIL will take special care of less developed market, transferring and adapting all the knowledge of its partners but will also work on improving the more developed market that have big challenges such as illiquidity and co-investments ESIL will target all the members of local BA groups, as well as individual investors, successful entrepreneurs, institutional players in EU28 and H2020 Associate Countries Connecting ecosystem actors (including policy makers) and investors and demonstrating how this pays off will contribute to short-term impact and sustainability. The interaction among different communities and typology of stakeholders (for profit and not for profit, conventional and unconventional, etc.) made possible by the nature of the consortium partners, will promotes cross-fertilization, mutual understanding and open up opportunities for further cooperation and take up.

Keywords: cross border investments,local champions,ecosystem
Photocatalytic Reductive Coupling of Imines: A New Platform for Chiral Amine Synthesis (PHOTOCAMSYN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-21
End date: 2020-06-20
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Chiral α-branched amines and their derivatives are commonplace in pharmaceuticals, agrochemicals and biologically relevant natural products. Accordingly, the development of new synthetically powerful methods for their synthesis, and/or further functionalisation, through new carbon-carbon bond forming processes is both important and timely from academic and industrial perspectives. Such chiral α-branched amine motifs can be accessed from electrophilic imine substrates, through direct addition of carbon-centered nucleophiles such as organometallic reagents and electron rich π-nucleophiles. This traditional approach takes advantage of the easy formation of imines and their natural polarity and has led to numerous developments over the years. Whilst nucleophilic addition reactions dominate the chemistry of imines, polarity reversal is possible but requires the careful design of imine precursors able to stabilise anionic intermediates following deprotonation. Free radical chemistry offers the possibility to reverse the polarity of imine derivatives; the formal addition of a hydrogen atom to the C=N π-bond can generate a nucleophilic α-amino radical able to react with alkenes and alkynes. However, to date these approaches have been limited by the way the radical is generated. Here we propose a new and broadly applicable ‘umpolung’ approach to access chiral α-branched amine motifs directly from imine substrates. Our plan is to design and develop a new reductive photochemical system that will allow the direct generation of ‘free’ nucleophilic α-amino radical species capable of undergoing a broad range of synthetically useful carbon-carbon bond forming processes. This non-classical umpolung strategy has a wealth of untapped synthetic potential and will allow the development of new modes of reactivity each in turn rendering new suites of synthetic methodologies including catalytic asymmetric versions.

Keywords: imine,umpolung,photoredox catalysis,target synthesis,enantioselectivity
SOCIAL INNOVATION IN ENERGY TRANSITIONS: Co-creating a rich understanding of the diversity, processes, contributions, success and future potentials of social innovation in the energy sector (SONNET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Switzerland,Poland,Belgium,France,Netherlands,United Kingdom,United Kingdom
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2018-NZE-CC, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 2999832.5
EU funding (EUR): 2999832.5
Participants: 12
Project status: CLOSED

SONNET aims to create an inter- and transdisciplinary understanding of the diversity and processes of social innovations in the energy sector (SIE). It assesses - critically and reflexively- the success, contributions and future potential of SIE towards sustainable energy transitions in Europe. SONNET investigates how, to what extent and under which enabling conditions diverse types of SIE may result in new breakthroughs or successfully help to overcome transition barriers; such as limited citizen engagement or slow adoption of new technologies. SONNET’s empirical research is informed by a novel conceptual framework combining insights from sustainability transitions, energy studies and social innovation literatures. It bridges qualitative and quantitative methodological approaches in an innovative multi-method research design. Across 30 qualitative in-depth case studies situated in six European countries, SONNET investigates the diversity, processes, success and contributions of SIE. Given its focus on urban areas as major hubs for SIE, SONNET conducts six transdisciplinary SIE city labs to experiment with new forms of SIE and learn about how multiple actors can harness the potential of SIE. In addition, based on three large-scale representative citizen surveys, SONNET assesses the future potential of SIE and derives implications for reconfiguring existing and developing new business models. SONNET synthesizes its findings in an integrated knowledge framework for a socio-economic, socio-cultural (incl. gender) and socio-political understanding of enabling and impeding conditions for SIE and SIE contributions when working towards accelerating sustainable energy transitions in Europe. Through a cutting edge co-creation, dissemination and exploitation strategy, SONNET ensures that its practical recommendations, tools and capacity building activities have a maximum impact on its key stakeholders such as citizens, SIE actors, policy makers, and businesses.

Keywords: social innovation,socio technical transitions,energy union,cities,co creation,multi method design,social acceptance,business models,governance,energy policy
ETIPWind- Aligning Wind Energy Research and Innovation Strategies (ETIPWind)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to sectorial fora (H2020-LC-SC3-2018-Joint-Actions-3, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 726637.5
EU funding (EUR): 726637.5
Participants: 1
Project status: CLOSED

The overall objective of the ETIPWind project is to continue and enhance the activities and deliverables of the current ETIPWind. The project will bring together key stakeholders of the wind energy sector (industry and academia) and the broader energy sector to assess challenges and articulate common Research & Innovation priorities. The ETIPWind project aims to inform the European Commission's SET-Plan and the Research & Innovation implementation plan on EU's Research & Innovation policy to sustain Europe's global competitive edge in wind energy and deliver on the EU's Climate and Energy targets cost-effectively.

Keywords: wind energy,platform