Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role and Modulation of Jak and STAT signaling in Graft Rejection and Graft versus Host Disease (HSCT AND JAK-STAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-02-01
End date: 2014-01-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Our interest is to extend the understanding of Jak and STAT signaling in the immunologic processes conditioning the outcome of allogeneic hematopoietic stem cell transplant (allo-HSCT) and to develop new strategies to overcome graft rejection (GR) and graft versus host disease (GVHD). Allo-HSCT is a potentially curative strategy for many patients. GR and GVHD hamper the success of allo-HSCT by conditioning treatment related mortality. The Janus family of kinase (Jaks) dictates T helper (Th) cells differentiation through the activation of different members of the STAT family. We hypothesize that Jak and STAT signaling play an important role for mediating GR and GVHD and propose to: 1) evaluate the activation of Jaks and STATs after transplant in patients with or without GVHD; 2) analyze the kinetics of activation of Jaks and STATs in mouse models of GR and GVHD; 3) determine whether Jak3 has a non-dispensable role in alloreactive-driven, such as GR and GVHD, or homeostatic-driven T cell expansion; 4) explore the possible interaction between STAT6 and STAT1 to dictate Th differentiation; 5) modulate GR and GVHD through the pharmacological manipulation of Jak signaling. We plan to achieve these objectives by an inter-disciplinary approach consisting of the analysis of in vitro experiments, in vivo data and clinical data. Jak and STAT signaling will be studied on lymphocytes form patients undergoing allo-HSCT. In parallel, in vivo mouse models will explore the role of different Jak-STAT molecules in the onset of GR and GVHD by PCR, phospho-flow cytometry and western blotting. We will utilize mice deficient for different Jak-STAT molecules to demonstrate the causal role of these proteins in GR and GVHD. These mouse models will be instrumental to test the efficacy of new drugs that can modulate Jak and STAT signaling, such as CP-690,550. Funding of this proposal will foster the European reintegration of a scientist with extensive training in the United States.

Keywords: health sciences,haematology
Week of Innovative Regions in Europe (WIRE2010)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Regions of Knowledge
Action type: Coordination and support actions
Countries involved: Spain
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2009-09-01
End date: 2010-12-31
Duration (months): 16.0
Total project cost (EUR): 632666.0
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

The Week of Innovative Regions in Europe (WIRE2010) will be held in Granada on 15-17 March 2010, under the auspices of the Spanish EU Council Presidency. The event will focus on how to move from “synergies of policies” to “synergies of actions” for the optimal use of EU instruments, with the objective of making regions full protagonists in building the knowledge-based society. WIRE2010 is the result of merging three different sub-conferences: A. Conference on the efficient and effective use of budget earmarked in the Structural Funds for RTD and Innovation, including their synergies with the FP and the CIP. B. “Research Potential” conference, which focuses on the assessment of the results and the identification of best practices of the Research REGPOT programme (Capacities – FP7). C. “Regions of Knowledge” conference, which deals with the assessment of the results and the identification of best practices of the REGIONS programme (Capacities – FP7). WIRE2010 will be a high-level forum for discussion of stakeholder&apos;s good practices and ideas on how to make the best of European, national and regional funding for R&amp;D and innovation and more efficient ways to conduct future actions. In this line, REGPOT and REGIONS programmes (Capacities – FP7) can play a crucial role and therefore will have a whole dedicated conference on the second day.

Keywords: regions,instruments,research,innovation,spanish presidency
Exploitation of ground-based Global Navigation Satellite Systems (GNSS) for Meteorology and Climate studies in Bulgaria/Southeast Europe (GNSS METEOROLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Bulgaria
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-01-01
End date: 2014-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The Global Navigation Satellite Systems (GNSS), a new technology that revolutionised the navigation, is becoming an indispensable part of our daily life with millions of chips installed in portable car navigation devices and mobile phones. Beside the numerous civilian and commercial applications, GNSS proved to be an accurate sensor of the most abundant greenhouse gas, namely atmospheric water vapour. Application of GNSS in Meteorology is a well established research field in Europe and GNSS data from 1,200 stations are available for model validation and assimilation in state-of-the-art models used for operational weather prediction by the National Meteorologic Services. Advances in GNSS data processing is making possible to also use the GNSS data for climatic trend analysis, an emerging new area of research that is both attractive and important. This project is a first step towards application of GNSS for Meteorology and Climatic studies in Bulgaria and Southeast Europe. The work will be conducted in close collaboration with the University of Bern, Switzerland and the Delft University of Technology, Netherlands. It is expected to foster national links that will lead to integration of the GNSS data from Bulgaria in the European data exchange within EUMETNET – EGVAP project. A user friendly water vapour database will be developed and used for (1) cross-validation of ground-based and satellite observations and derivation of systematic biases, (2) validation of numerical models used for research and weather prediction, (3) study of water vapour distribution in Bulgaria and Southeast Europe, (4) detection of long term trends in water vapour and links to heat waves, droughts and changes in the pathway of the Atlantic Cyclones, and (5) studies of accuracy of state-of-the-art climate models for Bulgaria and Southeast Europe.

Keywords: global navigation satellite systems (gnss),gnss meteorology and climatology,observation systems (climate change),satellite gnss technology,numerical weather prediction
Chemogenomic profiling of drug-protein binding by shape, enthalpy/entropy and interaction kinetics (DRUGPROFILBIND)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Germany
Call:  (ERC-2010-AdG_20100317, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 1754615.28
EU funding (EUR): 1754615.28
Participants: 1
Project status: CLOSED

Once a new drug target is discovered, screening techniques are applied to detect prospective hits. However, which hit should be taken to the next level of development? This decision is most crucial as it entails huge financial commitments of the subsequent drug optimization. In consequence drugs are only developed against diseases that promise short-term profit. Chemogenomic profiling allows to compile parameters characterizing binding of drug candidates that achieve optimal interference with protein function. Membrane proteins demand different properties than viral ones. Either high isoform selectivity, promiscuous family-wide binding or efficient resistance tolerance is desired. This calls for very different ligand binding characteristics, requiring either enthalpy-/entropy-driven binding, rigid shape complementarity or pronounced residual mobility at the binding site. Interaction kinetics determine on/off-rates and the time a drug spends with its target. Their correct adjustment is essential for drug efficacy. At present chemogenomic binding parameters are rarely available and their correlation with the required target properties is hardly understood. We want to compile a knowledge base from congeneric protein-ligand series to correlate structural, thermodynamic, interaction-kinetic and dynamic behaviour to predict the qualities a lead must meet to optimally address a target. Our studies involve crystal structure analyses, microcalorimetry, molecular dynamics simulations, site-directed mutagenesis and interaction kinetics. This provides a comprehensive picture to productively change our current understanding of drug-protein binding to move from a current trial-and-error to a more efficient rational approach. It provides the opportunity to also consider orphan drugs and address neglected diseases.

Keywords: biomolecular recognition,thermodynamic signature,structure-based drug design,protein-ligand interactions,lead optimization,hit-to-lead-to-drug optimization,crystal structure analysis
European Contest For Young Scientists (EUCYS2010)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Science in Society
Action type: Coordination and support actions
Countries involved: Portugal
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2010-03-03
End date: 2011-03-02
Duration (months): 12.0
Total project cost (EUR): 1047256.11
EU funding (EUR): 600000.0
Participants: 1
Project status: CLOSED

The European Union Contest for Young Scientists, an initiative of the European Commission, was set up in 1989 to promote the ideals of cooperation and interchange between young scientists. The Contest is the annual showcase of the best of European student scientific achievement and as such attracts widespread media interest. The 22nd. EU Contest of Young Scientists will take place 24-29 September 2010, in Lisbon, Portugal, at the Electricity Museum. Host organizer is Youth Foundation / Fundação da Juventude, a national non-profit organization with 20 years of experince on youth policies. The EU Contest gives students the opportunity to compete with the best of their contemporaries at European level. The young scientists also have the chance to meet others with similar abilities and interests and to be guided by some of the most prominent scientists in Europe. In this way, the Commission seeks to strengthen the efforts made in each participating country to attract young people to careers in science and technology. The EU Contest for Young Scientists is part of the Science and Society activities managed by the Directorate-General for Research of the European Commission. Within the Framework Programmes for Research and Technological Development, and the European Research Area, Science and Society aims to build a more harmonious relationship between scientific endeavour and the European society at large.

Keywords: the eucys promotes the ideals of cooperation and interchange between young scientists. it is the annual showcase of the best of european student scientifc achievement.
Multi-scale material modeling for micro-manufacturing of micro-feature arrays on large surface areas (MICROMANUFACTURING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-01-01
End date: 2014-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project is proposed by Dr. Muammer Koç (Principal Investigator, PI) under the International Re-integration Grant (IRG) program to support his re-integration to research and education activities in EU and at the Istanbul Sehir University (SEHIR), and to facilitate a successful and continuous integration of his research in the micro-manufacturing field of science and engineering into the EU’s needs and trends. The overarching goal of this research proposal is to investigate, develop and validate accurate multi-scale material behavior models for micro-manufacturing technology. Micro-manufacturing research deals with the material behavior, process control, deformation mechanics, tribology and machine design for robust, precise, cost-effective and zero-waste fabrication of micro-scale parts (e.g., pins, connectors, gears, pumps, etc.) and micro-feature arrays on large surface areas (e.g., micro-channels, micro-pyramids, micro-cones, micro-bumps). Products or components of the second type represents good examples, and thus challenges, of multi-scale design, material modeling and manufacturing. To enable cost effective, robust and quality manufacturing of fuel cells and other similar applications, accurate modeling of micro-manufacturing processes is a must. Only with such accurate and proven models, scientists and engineers may effectively design, analyze, and manufacture micro-feature arrays on large surface areas, as in bipolar plates (BPP) of fuel cells. The prediction accuracy and effectiveness of such models hinges on the accuracy of the material behavior models at the micro-scale, where size effects become significant. The ultimate objective of this research is to establish a systematic approach for rapidly and accurately testing and modeling the behavior of metallic materials between different length scales (macro-, meso-, and micro-scales).

Keywords: technological sciences,microengineering,precision engineering,simulation engineering,materials engineering
Demonstration of integrated and sustainable enclosed raceway and photobioreactor microalgae cultivation with biodiesel production and validation. (INTESUSAL)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: United Kingdom,Belgium,Netherlands,United Kingdom,Germany,Netherlands,Netherlands,Türkiye,Portugal
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-05-01
End date: 2016-07-31
Duration (months): 63.0
Total project cost (EUR): 8642970.51
EU funding (EUR): 5000000.0
Participants: 11
Project status: CLOSED

The project will demonstrate an integrated approach to generate biofuels from algae in a sustainable manner, on an industrial scale. The project will make optimum use of glycerol, a waste material arising from biodiesel production. It will integrate prior high quality research which has been undertaken at national and international levels: both with public support and with private finance. The demonstration and associated demonstration activities to be undertaken in this work will help to enable increased security of energy supply for European Transport needs and greater penetration of Renewable Energy Resources (RES) as part of the drive to meet the European Commissions (EC) 20:20:20 objectives. The project will optimise the production of algae by both heterotrophic and phototrophic routes and will demonstrate integration of these production technologies (Raceway, PBR and Fermentation) to achieve the algae cultivation targets of 90-120 dry tonnes per hectare by annum. Accordingly, strain selection will be governed by the growth rate, oil yield and lipid composition achieved under local conditions. The project will select algae species and cultivation technologies to attain an algal oil with a suitable lipid profile for biodiesel production and will validate this selection through conversion of the extracted oil into biodiesel to meet standard specifications. The sustainability of this demonstration, in terms of both economic and environmental (closed carbon loop) implications will be considered across the whole process; including optimum use of algal biomass resources to enable commercialisation. This project will closely address the requirements of Topic ENERGY.2010.3.4-1, aligning it to the wider European requirements recognised by the EC; to increase security of energy supply, specifically for transport use that can be readily integrated into existing vehicles and infrastructures from indigenous sources and, to help to reduce greenhouse gas (GHG) emissions.

Keywords: algae,biodiesel,sustainability,photobioreactor,renewable energy,integrated production,closed carbon loop.
Highly Efficient Tubular Membranes for Oxy-Combustion (HETMOC)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Clean coal technologies
Action type: Collaborative project
Countries involved: Denmark,Germany,Germany,Belgium,Norway,France,France,Spain
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 7812392.0
EU funding (EUR): 5534142.0
Participants: 8
Project status: CLOSED

This project will develop and demonstrate Highly Efficient Tubular Membranes for OxyCombustion. Oxycombustion is a promising option for implementing cost-efficient carbon capture and sequestration (CCS) in future coal fired power plants. The use of oxygen membranes in the process has the potential to significantly reduce the efficiency losses associated with the capture and to improve the overall process economy. The multinational consortium behind the proposal includes industry as well as research centers, combining between them all the multi-disciplinary competences needed to carry out the project. The partners are: Risoe National Laboratory for Sustainable Energy (coordinator; DK), Forschungszentrum Julich GmbH (D), Fraunhofer IKTS (D), VITO (B), SINTEF (N), Air Liquide(Fr), Saint Gobain CREE (Fr) and INABENSA (ESP). Two different types of tubular oxygen transport membranes will be developed at the research centres participating in HETMOC, and the technology for producing the membranes will be transferred to an industry partner that will demonstrate membrane production by industrial processes. The fabricated membranes will be demonstrated over a period exceeding 1000 hours in a pressurized Proof of Concept module so as to address critical issues related to the practical operation. The module will hold 25 tubes of 1 m length. The knowledge obtained in both the development and fabrication of the membranes will, together with the experiences from the Proof of Concept module, be used for a conceptual design of an industrial scale module with a capacity of 100 tons per day. The cost of such a module will be assessed and an overall techno-economical evaluation of various ways of integrating oxygen transfer membranes in the power plant will be carried out to estimate the efficiencies of various schemes and to identify the most rewarding (in terms of overall cost and efficiency) routes for further development.

Keywords: oxygen membranes,oxygen combustion,carbon capture,storage,otm,oxy-combustion
In depth analysis of the role of essential kinases in regulation of meiotic chromosome segregation in Schizosaccharomyces pombe (AEKSP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2013-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Meiosis is a specialized cell cycle that enables diploid organisms to reproduce sexually by generating haploid gametes through two succesive divisions. To depict the detailed regulatory mechanism of meiotic chromosome segregation, the relevant proteins need to be identified and characterized. Protein kinases play important role and regulate multiple biological processes, including meiosis. Up to now, several kinases have been shown to be implicated in regulation of meiotic chromosome segregation. However, some kinases are essential for mitotic growth, a fact that precluded their detailed analysis in meiosis. Recently, we applied high-throughput knockout and chemical genetic strategies to construct the conditional analog-sensitive mutants of all known Schizosaccharomyces pombe essential kinases. Inhibition of particular kinases during meiosis and analysis of meiotic chromosome segragation in these mutants revealed that eight of these kinases play essential role for faithful chromosome segregation. The proposed project aims to analyze in more detail the molecular functions of selected essential kinases and define how these kinases regulate meiotic chromosome segregation. To elucidate the regulatory functions of these kinases, their role in meiotic recombination, in mono-orientation of sister kinetochores and in protection of centromeric cohesion will be analyzed. In addition, the proteomic approach will be applied to gain further insights into the kinases functions through identification of kinases targets and their postranslational modifications. In regard to the proposed project, the expected results could help us to better understand the molecular mechanism how chromosome segregation is regulated during meiosis and in the long-run also the principles of gametogenesis as well as the reason of genetic disorders resulting from chromosome missegregation.

Keywords: schizosaccharomyces pombe,meiosis,kinases,chromosome segregation,conditional analog-sensitive mutants
Modification of Resin (RESMOD)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany
Call:  (SP1-JTI-CS-2010-01, 2010)
Start date: 2010-10-01
End date: 2011-09-30
Duration (months): 12.0
Total project cost (EUR): 73440.0
EU funding (EUR): 55080.0
Participants: 1
Project status: CLOSED

The aim of the proposal is to modify several epoxy resin systems designed for the manufacture of fiber reinforced composites. These modifications include the use of silica nanoparticles, toughneres like core shell elastomers and combinations thereof. The modified resin systems are adapted to the processing conditions in the manufacture of the FRCs. The modifications are selected to increse significantly the performance of the FRCs by means of toughness, stiffness, fatigue etc.

Keywords: epoxy resins,nanosilica,tougheners,fatigue