Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UNLEASHING THE POTENTIAL OF PUBLIC TRANSPORT IN EUROPE (UPPER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Belgium,Italy,Spain,France,Germany,Switzerland,Norway,Hungary,Portugal,Greece
Call: Unleashing the innovation potential of public transport as backbone of urban mobility (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 23575522.94
EU funding (EUR): 19993346.0
Participants: 43
Project status: SIGNED

UPPER aims at spearheading a Public Transport revolution that will strengthen the role of PT as the flagship of sustainability and innovation of mobility in cities, leading the transition towards a zero emission mobility which will become the cornerstone of climate neutrality by 2030, in line with the goal of Cities Mission and the priorities of the Green Deal. UPPER will put the Public Transport at the centre of the mobility ecosystem and will implement a combination of 84 push and pull measures, acting on the 5 innovation axes that condition user’s choices: mindset and culture, urban mobility planning, mobility services ecosystem, road network management and democratic governance. These measures will act in 4 different timescales (from shorter to longer-term): communication, operations, infrastructure and urban fabric. The UPPER measures will be supported by the UPPER Toolkit (U-TWIN, U-SIM, U-NEED, U-GOV, U-KNOW, U-TRANSFER and U-SUMP), 7 IT tools combining social and technological innovation that will be demonstrated within the measures in the 5+5 UPPER living labs and twinning sites, with the overall target of increasing the use of public transport by >30% and the user satisfaction by >25%, leaving nobody behind in the process. This integrated and holistic approach will ease the cooperation among authorities and operators, offer a physical and digital environment to test the measures, update the existing SUMPs, optimise the PT offer in line with user needs and patterns, involve the users in the overall mobility decision chain, trigger the behavioural change in favour of Public Transport and achieve an attractive, efficient, reliable, safe, inclusive and affordable Public Transport system in line with the concept of Mobility as a Right (MaaR)

Keywords: cities mission,sumps,mobility as a right,climate neutrality,smart cities,green deal,civitas,maas,multimodal digital mobility services,mdms,sustainable urban mobility plan
EXamining how Past demography affects genetic LOad using Ancient DNA (EXPLOAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 625229.0
EU funding (EUR): 625229.0
Participants: 2
Project status: SIGNED

DNA can survive millennia post-mortem, spanning ecological and evolutionary transitions and providing a unique window into the processes underlying biodiversity. As such sequencing ancient DNA from temporally spaced samples can allow the testing of hypotheses related to evolutionary responses to ecological change and novel selection pressures through direct quantification of ecological and genetic parameters collected before, during and after genetic changes in selection pressures. Here, I propose to do just this, taking advantage of a natural experiment of an emblematic study system in evolutionary biology: parallel independent adaptation to freshwater by marine-adapted threespine sticklebacks through the rise in frequency of freshwater-associated alleles. Utilising palaeogenomics to sample genomes along this evolutionary continuum and the project will address a key and long-standing question: is there a mutational cost to natural selection? This is a timely question, as ongoing rapid global climatic change is a major source of novel selection pressures, therefore, understanding the dynamics of natural selection will provide key insights into potential outcomes for biodiversity. The methods developed in this project will not only benefit the growing field of paleogenomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology. Ultimately, achievement of these goals requires the formation of a dedicated, closely knit team, focusing on both the methodological challenges as well as their bigger picture application to high-risk high-gain ventures. With ERC funding this can become a reality, enabling the interface of palaeogenomics and evolutionary biology to be pushed to the new limits of the modern sequencing era.

Keywords: mutation load,ancient dna,adaptation,threespine stickleback
PRogrammable AI-Enabled DeterminIstiC neTworking for 6G (PREDICT-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Spain,Hungary,Germany,Romania,Estonia,Italy,United Kingdom,Greece
Call: System Architecture (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 6082687.5
EU funding (EUR): 5681350.0
Participants: 19
Project status: SIGNED

6G is envisioned to accelerate the path started in 5G for catering to the needs of a wide variety of vertical use cases, both current and emerging. This will require major enhancements of the current 5G capabilities especially in terms of bandwidth, latency, reliability, security, and energy. PREDICT-6G’s mission is therefore set towards the development of an end-to-end 6G (E2E) solution including architecture and protocols that can guarantee seamless provisioning of services for vertical use cases requiring extremely tight timing and reliability constraints. To succeed, the solution will target determinism network infrastructures at large, including wired and wireless segments and their interconnections. PREDICT-6G will develop a novel Multi-technology Multi-domain Data-Plane (MDP) overhauling the reliability and time sensitiveness design features existing in current wired and wireless standards. The ambition is for the MDP design to be inherently deterministic. To achieve this, PREDICT-6G will develop an AI-driven Multi-stakeholder Inter-domain Control-Plane (AICP) for the provisioning of deterministic network paths to support time sensitive services as requested by end-customers and with different scaling ambitions, e.g., from the network in a single vehicle to a large, geographically dispersed network. This requires timely monitoring and prediction of the behavior of the complete network, including identifying potential sources of quality violations and analyzing various routes of the traffic flows. These capabilities will be delivered through the PREDICT-6G AI-powered Digital Twin (DT) framework, allowing the prediction of the behavior of the end-to-end network infrastructure, and enabling anticipative control and validation of the network provisions to meet the real-world time-sensitive and reliability requirements of the running services.

Keywords: determinism,reliability,time engineered,predictable,wifi,3gpp,ai,digital twin
A Gathering place to cO-design and co-cReate Adaptation (AGORA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Austria,Sweden,Greece,Switzerland,United Kingdom,Estonia
Call: Local engagement of citizens in the co-creation of societal transformational change for climate resilience (HORIZON-MISS-2021-CLIMA-02, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3706156.25
EU funding (EUR): 3706156.25
Participants: 13
Project status: SIGNED

AGORA will support the overall objectives of the Mission on Adaptation to Climate Change by leveraging and step forwarding best-practices, innovative approaches, policy instruments and governance mechanisms to meaningfully and effectively engage communities and regions in climate actions, accelerating and upscaling adaptation process for building a climate resilient Europe. It will promote democracy, climate justice, gender equality, equity, and foster adaptive capacity and citizens’ empowerment to pro-actively support decision-making processes. AGORA’s main ambition, beyond the state of the art, is to promote societal transformational processes in different social, economic and political contexts through transdisciplinary tools and approaches. Citizens, civil society organizations, academics, experts, policy-makers, entrepreneurs and other relevant actors will be engaged in the co-design and co-creation of innovative problem oriented climate adaptation solutions that could be extensively adopted in Europe also considering the deep social changes on going and the awareness that no one size fits all solution. Specifically, AGORA will provide: • A package of digital tools and co-developed frameworks relying on multi-directional communication technologies. • Innovative problem-oriented climate adaptation solutions. • Blueprints for effective decision making and collaborative processes that build on the dialogue among stakeholders and on the integration of different types of knowledge. A set of pilot regions will constitute the co-production arena to co-design, co-develop and co-implement climate adaptation solutions. AGORA will also develop a roadmap for transformational change and upscale of citizen engagement, for transferability of effective policy instruments and for ensuring long term legacy.

Keywords: citizen engagement,disinformation,public awareness,societal transformation,resilient europe,transformative knowledge,co designed solutions,upscaling adaptive solutions,co creation processes
2nd Life for Power Plants (2LIPP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Denmark,Germany,Sweden,Netherlands,Poland,Belgium
Call: Demonstration of innovative forms of storage and their successful operation and integration into innovative energy systems and grid architectures (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2027-09-30
Duration (months): 57.0
Total project cost (EUR): 11681389.1
EU funding (EUR): 7984492.5
Participants: 17
Project status: SIGNED

The 2LIPP project will partially retrofit the Bornholm CHP plant with a scalable hybrid energy storage system consisting of three low-cost, storage technologies (novel molten hydroxide salt storage, lithium battery which is based on reused car batteries, and a flywheel, based on non-rare metals and with unprecedented lifetime), which all improve state-of-the art in their own way – also within sustainability. The technologies will be operated through an innovative management system (EMS) to charge and dispatch the hybrid storage system in the best way possible. The 2LIPP demonstration will serve as a proof-of-concept for a disruptive approach to transitioning traditional power and combined heat and power plants away from fossil fuels, while maintaining a secure supply of energy and stability of the electrical grid. The 2LIPP concept greatly reduces the costs of energy storage by reusing existing facilities at power plant sites. Also, the innovative combined operation of several technologies through the EMS allows for deployment of storage technologies in their relative ‘sweet-spots’ leading to optimal efficiencies and improves lifetimes. The low cost and high efficiency that stems from the 2LIPP approach will accelerate the availability of storage technologies and systems to bring about net zero in the electrical and heating sectors. Deploying hybrid storage with the 2LIPP concept can maintain the role of power plants as critical nodes in the grid, and enable these sites to provide grid stability at both short and long timescales, thus ensuring that Europe can integrate renewable energy without a rising risk of blackouts. The project also develops feasibility case studies for utility companies to serve possible road maps for utility companies to decide on the most viable investment for retrofitting their plants.

Keywords: energy storage,flywheel,molten salt,batteries,energy management system
Targeting Epstein-Barr Virus Infection for Treatment and Prevention of Multiple Sclerosis (EBV-MS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Belgium,Italy,Sweden,United States,Spain,Cyprus
Call: Relationship between infections and non-communicable diseases (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 8169913.0
EU funding (EUR): 7549863.25
Participants: 16
Project status: SIGNED

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS). It constitutes the most common non-traumatic cause of neurological impairment among young and middle-aged people and represents a major healthcare burden. Our recent research strongly implicates infection by the Epstein-Barr virus (EBV) as the leading cause of MS, but detailed understanding of the mechanisms how EBV contributes to the disease, and whether targeting EBV could prevent or improve the course remain unresolved. To meet these challenges, we have established a consortium with extensive experience in neurology and MS, genetics, virology and EBV, epidemiology, immunology, clinical trials, artificial intelligence, as well as stakeholder involvement and responsible research and innovation (RRI). By combining this expertise, the consortium takes advantage of high-quality health registries, existing research cohorts of persons with MS, and prospective randomized clinical trials of antiviral therapies targeting the EBV infection in MS. The ambitious goals are to answer the questions why only a few EBV infected persons develop MS, and define the underlying mechanism of this process, as well as clarify if targeting the EBV infection can prevent MS or improve the disease course. By answering these questions, we would meet the challenges defined in the current call: Relationship between infections and non-communicable diseases. We would contribute with knowledge to reduce disease burden by providing the health care system with new knowledge to better understand the cause of MS, including host risk factors that influence the development of the disease. We would also provide a basis for new or improved tools to prevent MS or disease progression. Healthcare practitioners will gain access to knowledge to guide them on preventive measures and of those persons at risk of developing MS, with the ultimate goal of eradicating the disease.

Keywords: viral host genetics,immune response,disease modelling,disease prevention
Development of Fusogenic Immunomodulatory Macrophage-Mimicking Nanocarriers for Targeted Delivery to Inflamed Tissue (NANO-MAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

In this project, we propose to develop innovative macrophage-mimicking nanocarriers (MMCs) with fusogenic properties (FMMCs) for the targeted delivery of dexamethasone to inflammation sites, particularly for treating Inflammatory Bowel Disease (IBD). These nanocarriers, designed to mimic the natural targeting abilities of macrophages, aim to enhance therapeutic efficacy and reduce systemic side effects. To achieve this, we will first synthesize and optimize MMCs, incorporating fusogenic properties to improve cellular uptake and drug delivery efficiency. These will then be evaluated for biocompatibility, cytotoxicity, and their ability to modulate immune responses. Finally, we will test the (F)MMCs in a sophisticated in vitro model mimicking the gut-immune interface to assess their performance in a disease-relevant environment. The successful execution of this project will not only advance the field of nanomedicine but will also contribute to a better understanding of nanoparticle-cell interactions and their potential in immunomodulation, paving the way for more effective and safer therapies for chronic inflammatory diseases. Overall, this project will allow me to independently lead a 2-year research initiative, advancing my expertise in the field of nanomedicine and drug delivery systems, and positioning me as a mature and independent researcher capable of contributing to the development of innovative therapies for chronic inflammatory diseases.

Keywords: macrophage mimicking nanocarriers fusogenic targeted delivery inflammation
u-Space sePAraTIOn management (SPATIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Germany,France,Ireland,Italy,United States,Romania,Belgium,Finland
Call: Fast Track Innovation and Uptake U-space and Urban Air Mobility (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 10417196.25
EU funding (EUR): 6996206.01
Participants: 23
Project status: SIGNED

SPATIO (u-Space sePAraTIOn management) will research the U-space services addressing separation between UAVs, in particular, strategic and tactical conflict resolution services and the relationship between separation and capacity in U-space airspaces. i.e., the relation with the Dynamic Capacity Management service.

Keywords: u space,uavs,separation,tactical conflict resolution,dynamic capacity management,strategic conflict resolution
Time-Evolving Stochastic Manifolds (StochMan)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1997651.0
EU funding (EUR): 1997651.0
Participants: 1
Project status: SIGNED

Uncertainty is all around us and caused, for example, by the nature of a problem as in quantum mechanics, the lack of our precise knowledge as in porous media, or inaccuracies in measurements as in experiments with imperfect equipment. While traditionally and due to the lack of computing power, science and technology relied on deterministic models, recent developments allow to include randomness. This trend requires efficient simulation methods for models with uncertainty. In space-time problems such as moving biological cells and the surface of the ocean, the randomness could be modeled by a stochastic process given explicitly or described by stochastic PDEs. Fast and accurate methods for sampling the stochastic processes are the key when computing statistical quantities of the advanced models. The main contribution of the project is the development of a theoretical framework for evolving stochastic manifolds and their efficient simulation with analyzed algorithms. Special emphasis is paid to the situation when the evolving stochastic manifold is a moving surface disturbed by external forces and described by stochastic PDEs. The main steps of the project are divided into three objectives: Obj. (A) From random fields on manifolds to stochastic manifolds. Obj. (B) From stochastic processes to evolving stochastic manifolds. Obj. (C) Solving PDEs on stochastic manifolds. The challenges are tackled based on recent advances in the simulation of Gaussian random fields on manifolds and their analysis obtained by the research team of the PI. This new breakthrough paves the way for the development of sampling methods for stochastic processes on manifolds and ultimately to evolving stochastic manifolds. To reach these goals, the PI's research group is complemented by specialists in geometric numerical integration, numerical methods for (stochastic) PDEs, and spatial statistics.

Keywords: random fields,riemannian manifolds,stochastic processes,efficient algorithms,regularity,convergence analysis,evolving surfaces