Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protecting the planet’s bloodstream: feasible and just opportunities to safeguard freshwater’s Earth system functions (AQUAGUARD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1498561.0
EU funding (EUR): 1498561.0
Participants: 2
Project status: SIGNED

Freshwater has a fundamental role in regulating the state of the Earth system. Various human actions modify the water cycle, disturbing the Earth system functions it provides, such as mediating the planet’s energy balance and sustaining ecosystems. Humanity’s impact on these functions has not been quantified comprehensively, nor do we know what human actions drive water cycle modifications (WCMs) in different parts of the world. This knowledge gap has made it impossible to acknowledge freshwater's crucial Earth system functions in decision-making. As human pressures on the water cycle continue to increase, there is an urgent need for bridging the gap between Earth system science and water management and governance, to safeguard freshwater’s life-supporting Earth system functions. AQUAGUARD rises to this challenge by 1) providing quantifications of the full extent of humanity's disturbance of the Earth system functions of freshwater, globally and in a spatially explicit manner, using novel indicators and spatial delineations; 2) using novel computational methods that will provide new insights into the complex driver interactions behind WCMs; 3) quantifying crucial Earth system impacts of WCMs, using modelling and meta-analysis, and 4) identifying feasible and just opportunities to safeguard freshwater’s Earth system functions, using AQUAGUARD’s quantifications combined with novel indicators of feasibility and equity aspects of freshwater change – at scales that are appropriate for water management and governance. AQUAGUARD addresses fundamental knowledge gaps at the intersection of hydrology, ecology and biogeochemistry, and provides various new methods and ground-breaking scientific results that will illustrate water as an integral part of the Earth system. By doing so, the project opens up new research avenues within and across these fields and expands perspectives in water management and governance from predominantly local to local-to-global.

Keywords: water resources,earth system,global change,global modelling
Linking Synchronic and Diachronic Analysis of Paradigms (LSDAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Speakers of even highly irregular inflecting languages can usually produce all forms of all lexemes (e.g. do, does, did…). How they can do so on the evidence of skewed and partial input is known as the Paradigm Cell Filling Problem. The increased availability of large inflected lexicons, and computing power and tools to assess cell-to-cell predictive uncertainty have enabled us in recent years to automatically measure multiple aspects of paradigm complexity and structural similarity. Unfortunately, this quantitative turn in morphology has been almost entirely limited to synchronic analyses. This project seeks to harness the power of novel quantitative methods (e.g. Information and Set Theory, Bayesian models) for the study of paradigmatic change as well. The focus will be on Romance verbs, as the most historically documented and best-understood inflectional system worldwide. Regarding synchronic variability, I will integrate the best and largest extant inflected lexicons in the family (5000+ complete verbs for the 5 largest Romance languages and Latin). All forms will be annotated for lemma-level and cell-level cognacy to produce a reusable and expandable pan-Romance etymological inflected lexicon. Turning to diachrony, one of the greatest obstacles to analyzing morphological change is distinguishing it from regular sound change. Given the large number of words and changes it is impossible to derive an optimal chronology of sound changes by hand. I will therefore write software that applies sets of ordered sound changes automatically to large inflected lexicons (e.g. of Latin) to derive expected forms. Comparing these to actual forms will reveal where morphological changes have occurred historically and enable us to explore what the best predictors are of analogical change: frequency, predictability, meaning, etc. This will allow us to evaluate more tractably competing hypotheses of phonological and morphological change and trends of change.

Keywords: morphology,linguistics,paradigm,romance languages
Food systems transformation towards healthy and sustainable dietary behaviour (PLANEAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Germany,Belgium,Spain,France,Sweden,Ireland,Poland,Greece,Hungary,United Kingdom
Call: Transition to healthy and sustainable dietary behaviour (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 11392817.5
EU funding (EUR): 11392817.5
Participants: 25
Project status: SIGNED

The EU food system is under considerable pressure for change due to its negative climate, environmental and health impacts. Food system transition will require changing dietary habits of millions of Europeans. PLAN’EAT aims at advancing the scientific basis on factors influencing dietary behaviour and the health, environmental and socio-economic impacts of dietary patterns and deliver solutions for transition through a transdisciplinary and multi-level approach. PLAN’EAT will co-create data and interventions in pan-EU network of 9 Living Labs and a Policy Lab. These living labs will focus on a broad range of population groups, varying according to age, culture, health and socio-economic status. PLAN’EAT entails four steps that feed into each other: (1) Dietary patterns of 9 different target groups from 9 regions will be mapped together with their food environments (2) Factors and drivers influencing dietary behaviour at macro- (food system), meso- (food environment) and micro- (individual) levels will be deeply investigated. (3) A True Cost Accounting database and methodology will be developed and applied, for the first time, on dietary patterns, providing integrated insights into the diverse impacts of current and future diets, including possible synergies and trade-offs. (4) A solution package will be co-developed with food chain actors, consumers and policymakers, incl.: i) a Food System Dashboard, setting out context-specific food policy recommendations; ii) interventions targeting Farm to Fork actors, for farmers, food industries, retailers and food services to create suitable food environments; iii) advisory tools to empower consumers; and iv) improved dietary advice and communication strategies to target populations at large. PLAN’EAT will allow for realizing a transition of 58500 consumers to healthier and sustainable dietary patterns by 2032, reducing premature mortality by 20% and greenhouse gases emissions of local food supply chains by 23% in 39 areas.

Keywords: consumer sciences,healthy and sustainable diet,food system,social sciences
DEMONSTRATING A HYDROGEN-POWERED GAS-TURBINE ENGINE FUELLED WITH UP TO 100% H2 – (HYPOWERGT) (HyPowerGT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Italy,Belgium,France,Switzerland
Call: Retrofitting of existing industrial sector natural gas turbomachinery cogeneration systems for hydrogen combustion (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 12269095.0
EU funding (EUR): 6000000.0
Participants: 9
Project status: SIGNED

The HyPowerGT project aims at moving technological frontiers to enable gas turbines to operate on hydrogen without dilution. The core technology is a novel dry-low emission combustion technology (DLE H2) capable of handling mixtures of natural gas and hydrogen with concentrations up to 100% H2. The combustion technology has been successfully validated at TRL5 (early 2021) retrofitted on the combustion system of a 13 MWe industrial gas turbine (NovaLT12). Besides ensuring low emissions and high efficiency, the DLE H2 combustion technology offers fuel flexibility and response capability on a par with modern gas-turbine engines fired with natural gas. The new technology will be fully retrofittable to existing gas turbines, thereby providing opportunities for refurbishing existing assets in industry (CHP) and offering new capacities in the power sector for load levelling the grid system (unregulated power) and for mechanical drives. The DLE H2 technology adheres to the strictest specifications for fuel flexibility, NOx emissions, ramp-up rate, and safety, stated in the Strategic Research and Innovation Agenda 2021-2027. System prototype. The new DLE H2 combustion technology will be further refined and matured and, towards the end of the project, demonstrated at TRL7 on a 16.9 MWe gas-turbine engine (NovaLT16) fired with fuel blends mixed with hydrogen from 0-100% H2. Within this wide range, emphasis is placed on meeting pre-set targets for (a) fuel flexibility and handling capabilities, (b) concentration of hydrogen fuel during the start-up phase, (c) ability to operate at varying hydrogen contents, (d) minimum ramp speed, and (e) safety aspects pertaining to any level with regard to related systems and applications targeting industrial gas-turbine engines in the 10-20 MWe class. A digital twin will be developed to simulate performance and durability characteristics, emulating cyclic operations of a real cogeneration plant in the Italian paper industry.

Keywords: dle combustion,dle h2,h2 gas turbine,fuel flexibility,cogeneration,chp,retrofit,load levelling,response power,clean hydrogen,european industry
Forgetting unwanted memories in sleep (SLEEPAWAY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1999769.0
EU funding (EUR): 1999769.0
Participants: 1
Project status: SIGNED

What we remember and forget lies at the core of who we are. But how do our brains shape our memories of the past? Sleep promotes the flexible use of memory by reactivating and thereby strengthening information that is most relevant to our future needs. Whether memory reactivation in sleep also weakens unwanted components of prior experience is unknown, but represents a major gap in our understanding of memory and how sleep influences our autobiographical identities. SLEEPAWAY combines an innovative technique for manipulating lab-based and real-world memories with an unprecedented array of neuroimaging methodologies to test the novel hypothesis that memory reactivation during sleep weakens unwanted memories in service of adaptive forgetting. Using magnetoencephalography with optically pumped magnetometers (OPM-MEG), I will first determine whether reactivating a target memory in slow-wave sleep weakens unwanted memories from the same experience, making them less accessible. Second, I will bring together OPM-MEG, fMRI and immersive virtual reality to obtain the first anatomically localised evidence of emotional memory reactivation in human rapid eye movement sleep, closing an important translational gap with extant animal models. Third, I will employ fMRI and EEG to examine the intriguing possibility that memory reactivation in sleep facilitates emotion regulation by weakening negative interpretations of real-world events, fostering a concrete pathway towards clinical intervention. Finally, to advance understanding of the symbiotic relationship between endogenous memory operations in the waking and sleeping brain, I will use OPM-MEG to test the prediction that active forgetting during wakefulness inhibits spontaneous memory reactivation in later sleep. In sum, SLEEPAWAY will make a substantial novel theoretical contribution by delineating the basic mechanisms through which our brains eradicate unwanted details of the past to support our cognitive and emotional goals.

Keywords: forgetting sleep
GATBIO NEXT: advancing GRT's 1st oral biologic - GB-AF-004 - to clinical demonstration and out-licensing (GATBIO NEXT)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

GAT Biosciences (GATBIO) is a women-led Biotech SME targeting the exploitation of its proprietary GRTTM technology as a novel solution for the development and production of complex biologic drugs for biopharma and veterinary markets. Specifically, we are developing a game-changer next generation of accessible and non-invasive (oral, topic, inhaled) biopharmaceuticals through proprietary and sustainable microalgae biofactories. Our first candidate for the biopharmaceutical Market, GB-AF-004, will enter pre-clinical demonstration in 2023. GB-AF-004 is an anti-inflammatory biologic for the oral treatment of Inflammatory Bowel Diseases and Disorders (IBDs). The term IBDs includes a range of chronic and painful autoimmune diseases affecting localy the intestine, affecting patients from their youth and throughout life and of unknown causess. More than 6 million people are affected by IBDs globally and their global treatment market is estimated by 2029 at 37 billion euros per year. GB-AF-004 has the potential to be a game-changer in the treatment of this high prevalence and chronic inflammatory intestinal diseases. GATBIO has been recently granted a Seal of Excellence from the EIC accelerator Program supporting disruptive European SMEs for their acceleration to the market. The related funding will allow us to enter the preclinical development of GB-AF-004 early in 2023. In this frame, additional support related not to scientific development per se but to reinforcing our strategic business management and vision could be key to success in our next steps and culminate GB-AF-004 out-licensing. Specifically, to access Expert mentoring and Biomed advice related to i) clinical positioning in the IBD market and ii) out-licensing strategy, would be key to success in the arrival of our 1st candidate to the regulated market and would translate into GATBIO’s consolidation and exponential growth based on innovation out-licensing.

Keywords: biologic drugs,microalgae synthetic biology,oral delivery,fundraising,out licensing
Measures for climate change adaptation and mitigation in European fisheries (MeCCAM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Faroe Islands,Iceland,Norway,Spain,Denmark,Germany,Cyprus,United Kingdom,Greece
Call: Minimising climate impact on fisheries: mitigation and adaptation solutions for future climate regimes (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 4721723.75
EU funding (EUR): 4500000.0
Participants: 16
Project status: SIGNED

The overall objective of MeCCAM is to develop, implement and recommend climate mitigation and adaptation solutions and increase the resilience and sustainability in the fisheries sector. MeCCAM employs an integrated multi-actor approach to deliver relevant and feasible results to support the fishing industry and policymakers. The outputs include: decision support tools allowing fishers to mitigate and adapt to climate change; innovative fishing gears to improve selectivity, fuel efficiency, and minimise habitat damage; and an environmental impact management software to reduce carbon emissions, and other impacts across the value chain. The solutions will be designed and implemented within six case studies (CSs) which have been selected for their suitability to address a multitude of challenges posed by climate change. MeCCAM also builds adaptive capacity by delivering: climate-informed advice prototypes for CSs; mitigation and adaptation plans at the CS level, as well as general recommendations; CS-specific plans for commercial utilisation of emerging species; and a policy brief on how to improve governance for mitigation and adaptation in the sector. Project outputs will be evaluated for their environmental and socio-economic efficacy in close collaboration with stakeholders. MeCCAM´s evidence-based and demand-driven solutions have a high potential for transferability to various regions and contexts and will provide actors with tools and pathways to advance climate resilience. MeCCAM will, therefore, contribute to the European Green Deal, the Common Fisheries Policy, the European Biodiversity Strategy for 2030, the Farm to Fork Strategy, United Nation’s Sustainable Development Goals 12, 13 and 14, as well as the Ocean Decade challenges 2, 3, 4, and 6.

Keywords: mitigation adaptation resilience fisheries sustainability
Evolutionary principles of nuclear dynamics and remodelling (KaryodynEVO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1615930.0
EU funding (EUR): 1615930.0
Participants: 1
Project status: SIGNED

Every eukaryote has a nucleus, a double lipid membrane-bound compartment that encapsulates the genome, but almost every nucleus is different - in shape, size, molecular composition, spatial organisation, and dynamics through the cell cycle. Given its fundamental and universal functional roles in protecting the DNA and regulating the exchange of information and control machinery between genome and cytoplasm, one might ask the question: why are there so many ways to build and remodel a nucleus? Bringing together comparative genomics, phylogenetics, quantitative cell biology and experimental evolution in multiple microbial model systems drawn from across the eukaryotic tree, we set out to elucidate the genomic, biophysical and evolutionary factors that determine nuclear dynamics and remodelling - karyodynamics - within the context of cellular architecture and function. A comparative perspective driven by phylogenetics will enable us to separate universal principles of karyodynamics from species- and niche-specific adaptations, and dissect the reasons for the evolutionary and developmental plasticity that we observe experimentally. In turn, we can use these principles to infer, predict and validate phenotypes in novel and emerging model systems. Finally, a more comprehensive understanding of the mechanisms responsible for karyodynamic phenotypic diversity would allow us to reconstruct evolutionary trajectories all the way back to the origins of the nuclear compartment, a landmark event in the evolution of eukaryotes from an archaeal-bacterial symbiosis over 2 billion years ago.

Keywords: evolutionary cell biology,nuclear remodelling,emerging model systems
Efficient Explainable Learning on Knowledge Graphs (ENEXA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Germany,Greece,Spain,Netherlands,Austria
Call: Verifiable robustness, energy efficiency and transparency for Trustworthy AI: Scientific excellence boosting industrial competitiveness (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3991270.0
EU funding (EUR): 3991269.5
Participants: 6
Project status: SIGNED

Explainable Artificial Intelligence (AI) is key to achieving a human-centred and ethical development of digital and industrial solutions. ENEXA builds upon novel and promising results in knowledge representation and machine learning to develop scalable, transparent and explainable machine learning algorithms for knowledge graphs. The project focuses on knowledge graphs because of their critical role as enabler of new solutions across domains and industries in Europe. Some of the existing machine learning approaches for knowledge graphs are known to already provide guarantees with respect to their completeness and correctness. However, they are still impossible or impractical to deploy on real-world data due to the scale, incompleteness and inconsistency of knowledge graphs in the wild. We devise approaches that maintain formal guarantees pertaining to completeness and correctness while being able to exploit different representations of knowledge graphs in a concurrent fashion. With our new methods, we plan to achieve significant advances in the efficiency and scalability of machine learning, especially on knowledge graphs. A supplementary innovation of ENEXA lies in its approach to explainability. Here, we focus on devising human-centred explainability techniques based on the concept of co-construction, where human and machine enter a conversation to jointly produce human-understandable explanations. Three use cases on business software services, geospatial intelligence and data-driven brand communication have been chosen to apply and validate this new approach. Given their expected growth rates, these sectors will play a major role in future European data value chains.

Keywords: explainable machine learning,trustworthy ai,hybrid approaches,knowledge graphs,tensors,embeddings,logics