Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles (SEAROX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-07
End date: 2021-08-06
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial R+D. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

Keywords: gold catalysis,oxazoles,heterocycles,cycloadditions,nitrenoids,annulations
Good practices in SME innovation support (GO - SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Estonia,Spain,Italy,Spain,Spain,Germany,Malta,Belgium,Belgium,Hungary,Lithuania,Slovakia,Czechia,Luxembourg,Portugal
Call: Mutual learning and common tools and resources for national/regional schemes supporting innovation projects of start-ups and SMEs (H2020-EIC-Mutuallearning, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 18
Project status: SIGNED

Throughout the EU, the fragmentation of innovation ecosystems and the lack of interconnection between public national and regional agencies appear to be one of the main obstacles to securing support for the most promising SMEs. The GO-SME project responds to the need to provide financial support to SMEs and start-ups for the development of their innovative ideas. The aim of GO-SME is to share the best practices of participating research funding organisations (RFOs) and their mutual learning in designing programmes which would support SMEs and start-ups in an initial assessment of their innovative ideas so that they can progress to more advanced stages of innovation development. To achieve this aim, a combination of the following activities will be used: 1/learning from best practices already applied in support schemes for innovative SMEs and startups, 2/motivation of agencies from widening countries to design innovation support schemes for SMEs and start-ups, 3/cooperation in the setting up of comparable support schemes and sets of selection criteria, 4/sharing of best practices in the work with (international) experts and sharing of their pools 5/learning from best practices in providing coaching and mentoring services to innovative SMEs and start-ups 6/mutual opening up pools of coaches and mentors 7/offering of special services to running projects which will be selected as the most promising by an independent international panel. The added value of the project rests in its ambition to design national and regional programmes supporting innovative SMEs which could act as a pipeline for the EIC Accelerator and be part of the “plug-in” mechanism. At the same time, it can serve as a pilot project for a possible partnership co-funded from innovation ecosystems in the Horizon Europe programme.

Keywords: sharing best practices and mutual learning of all participating rfos,national and regional schemes for highly innovative smes and startups,selection of the best smes and startups for eic accelerator
Printing spatially and temporally defined boundaries to direct the self-organization of cells and cellular aggregates to engineer functional tissues (4D-BOUNDARIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2703115.0
EU funding (EUR): 2390615.0
Participants: 2
Project status: SIGNED

Regeneration of musculoskeletal tissues requires engineered grafts that mimic the heterogeneous and anisotropic structure and mechanics of the native tissue. Despite decades of research, existing regenerative strategies have failed to produce tissues mimicking this exquisite structural complexity, dramatically limiting their clinical utility. Clues to addressing this grand challenge can be found in normal tissue development, which relies upon both the self-organizing potential of stem cells as well as key physical instructions from the microenvironment to establish final tissue architectures. Recognising this, the goal of 4D-BOUNDARIES is to leverage emerging 3D bioprinting technologies to provide precise physical boundary conditions and spatially localised morphogens to self-organizing cells and cellular aggregates to engineer structurally anisotropic and mechanically functional musculoskeletal tissues. To realise this goal, 4D-BOUNDARIES will build upon applicant’s extensive expertise in bioprinting and bioink development to produce two new biofabrication platforms that provide temporary guiding structures to self-organizing tissues. To demonstrate the utility of these bioprinting platforms they will be used to engineer, for the first time, patient-specific cartilage and meniscal grafts that mimic the internal and external anatomy and anisotropic mechanical properties of the native tissues. The ability to bioprint such functional tissues will transform the field of orthopaedic medicine, providing grafts to biologically resurface large areas of damaged articular cartilage and meniscus and thereby prevent the development of osteoarthritis – a debilitating disease affecting millions of people worldwide. The impact of 4D-BOUNDARIES will not be limited to the orthopaedic space, as it is envisioned that these new bioprinting platforms will find numerous applications in tissue engineering and regenerative medicine.

Keywords: bioprinting,articular cartilage,meniscus
Nanoporous Asymmetric Poly(Ionic Liquid) Membrane (NAPOLI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Sweden
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2021-07-31
Duration (months): 77.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1000000.0
Participants: 2
Project status: CLOSED

Nanoporous polymer membranes (NPMs) play a crucial, irreplaceable role in fundamental research and industrial usage, including separation, filtration, water treatment and sustainable environment. The vast majority of advances concentrate on neutral or weakly charged polymers, such as the ongoing interest on self-assembled block copolymer NPMs. There is an urgent need to process polyelectrolytes into NPMs that critically combine a high charge density with nanoporous morphology. Additionally, engineering structural asymmetry/gradient simultaneously in the membrane is equally beneficial, as it would improve membrane performance by building up compartmentalized functionalities. For example, a gradient in pore size forms high pressure resistance coupled with improved selectivity. Nevertheless, developing such highly charged, nanoporous and gradient membranes has remained a challenge, owing to the water solubility and ionic nature of conventional polyelectrolytes, poorly processable into nanoporous state via common routes. Recently, my group first reported an easy-to-perform production of nanoporous polyelectrolyte membranes. Building on this important but rather preliminary advance, I propose to develop the next generation of NPMs, nanoporous asymmetric poly(ionic liquid) membranes (NAPOLIs). The aim is to produce NAPOLIs bearing diverse gradients, understand the unique transport behavior, improve the membrane stability/sustainability/applicability, and finally apply them in the active fields of energy and environment. Both the currently established route and the newly proposed ones will be employed for the membrane fabrication. This proposal is inherently interdisciplinary, as it must combine polymer chemistry/engineering, physical chemistry, membrane/materials science, and nanoscience for its success. This research will fundamentally advance nanoporous membrane design for a wide scope of applications and reveal unique physical processes in an asymmetric context.

Keywords: porous membrane,polyelectrolyte,poly ionic liquid,asymmetric membrane
Improving the resolution of Neuroinflammation during repetitive mild Traumatic Brain Injury with dietary fatty acid Derivatives (INBID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Traumatic brain injury (TBI) represents a major health problem in Europe. Repetitive mild TBI (rmTBI) is a particularly dangerous form, due to its prevalence and limited overt clinical signs. This is concerning as rmTBI can lead to cumulative injury and is an established risk factor for dementia. Repetitive mTBI has been referred to as a ‘hidden epidemic’, but little is known about the pathological mechanisms. The project aims to address a major clinical need by identifying and validating new targets for the treatment of rmTBI. Microglia are critical components of neuroinflammation and are promising targets for intervention. It is now understood that nutrition and the amount of polyunsaturated fatty acids (PUFAs) contained within the diet can have profound effects on brain inflammation. Furthermore, specialised pro-resolving mediators derived from PUFAs have shown promise as interventions for disease. We hypothesise that the microglia-mediated inflammatory response to mTBI can be affected by manipulating PUFA levels to reduce the harmful, cumulative effects of a second mTBI. We will use a clinically relevant model of rmTBI in mice and investigate the resolution of inflammation during the period between injuries. These studies will be the first to integrate multiple parameters of microglia-mediated inflammation, combining transcriptomic and lipidomic profiling with unbiased network analysis to describe the resolution of inflammation in mTBI. Finally, by targeting of the most important network parameters, we will attempt to speed up the resolution of inflammation and so reduce the impact of rmTBI. The joined expertise of the applicant (neuroinflammation and microglia), the host lab (nutrition, lipids, behavior), and the secondment lab (transcriptomics and microglia) will guarantee the success of the project, validate new targets for the treatment of rmTBI, further the applicant's promising scientific career and bring new tools and approaches to the host laboratory.

Keywords: mild traumatic brain injury,resolution of inflammation,microglia,polyunsaturated fatty acids,lipids
Short Term Stent - A composite removable sinus stent for functional endoscopic sinus surgery that improves patient outcomes and reduces revision surgeries (STstent)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

STstent is a device implanted into a patient after FESS (functional endoscopic sinus surgery) to eliminate postoperative complications and revisions surgery. STstent not only improves the quality of life of patients but also reduces significantly costs for healthcare providers. We have been developing STstent since 2013 and the final design has been completed and first-in-man trials have been conducted. The trials showed the device has good therapeutic effectiveness and has minimal risks associated. We now intend to prepare STstent for commercialisation. For this, we need to carry out international clinical studies required for clinical approval and to demonstrate to healthcare providers the effectiveness of the device, as well as scale up the manufacturing process, and tighten our EU IP portfolio. We, STS Medical, were founded in late 2013 by 3 entrepreneurs with the shared vision to improve the quality of life of patients undergoing FESS procedures and improve the sustainability of healthcare worldwide. We boast vast experience in biomaterials, medical devices, quality assurance and regulatory affairs, product development and medical device marketing.
An all-in-one monitoring device for measuring the energy consumption of household appliances and providing real-time feedback to reduce environmental impact. (EcoFeel)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The household sector accounts for 29% of the overall electricity consumption in EU (795 TWh) and up to 39% globally. A poor electricity saving behaviour and the lack of awareness of our consuming practices’ impact on environment can increase household electricity consumption by up to 15%. EcoFeel is a smart energy advisor taking advantage of power and spectrum analysis in order not only to detect connected appliances through variations in current and voltage but also recognising their noise in the electrical network. This results in a deep monitoring of household’s electricity consumption making people more aware of their environmental impact. Ecoisme wants to optimise EcoFeel design to increase its performance in detecting appliances and monitoring household electricity consumption; In addition a more user friendly interface is forecasted. Large pilot testing of Ecoisme solution with support of stakeholders in the field of telecommunication and energy utilities will serve to demonstrate the reliability of the solution. global Energy Management System market, valued at €21 billion in 2015, and expected to grow at a CAGR of 17.3% – to reach €64.1 billion in 2022. Households’ owners and tenants will be the primary target of EcoFeel. According to Eurostat data updated to 2016, there were 220 million private households in the EU-28. The number of households is significantly less in the US with 117 million properties. This means an equivalent number of owners or tenants potentially interested in making their homes more energy efficient with a direct impact on environment. EcoFeel will contribute to the mitigation of global climate and energy challenges because it reduces household energy consumption and can minimise the impact on the environment accounting on human behaviour. The societal impact of the solution is also crucial. Ecoisme enables users to be aware and in control of their electricity consumption and costs, forming a more energy-conscious behaviour.

Keywords: household,appliance,electricity consumption,energy saving,energy advisor,power,spectrum,gamification
Impact Actions for social innovation agencies (ImpAct Agencies)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Italy,Hungary
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2018)
Start date: 2019-10-01
End date: 2021-02-28
Duration (months): 17.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 4
Project status: CLOSED

ImpAct Agencies intends to reshape and make more efficient, through the Twinning Advanced methodology, a set of services to support BICs and incubators. Through an open social innovation model, the project will allow BICs and incubators to support social impact SMEs and entrepreneurs to achieve a better impact and play an active role within the local social innovation ecosystem. By matching and integrating social entrepreneurship support programmes, policy strategies and online tools, ImpAct Agencies aims to design a modular kit of tools and services for accompanying entrepreneurs in improving their social impact. The consortium is composed by four Innovation Agencies: ART-ER (Italy) - the project coordinator, Fundecyt-Pctex (Spain), WestBIC (Ireland) and IFKA (Hungary). All of them already work on the topic of social innovation and social entrepreneurship in different ways: shaping policy instruments, developing specific networks and projects or supporting and implementing policy strategies at local level. This twinning advanced action has a multiple goal, since it will support partners in: - carry on a peer review and assessment on their respective service through an active stakeholder engagement activity; - reshape and combine those services linked to open social innovation model; - design a new service package for BICs and incubators dealing with social innovation ecosystems; - set up permanent relations within the partnership with the aim of improving each partners’ services and - build an interregional community of social innovation agencies. The final output of the project is the drafting of a complete Design Option Paper, dedicated to analyse and describe all different scenarios in terms of background, framework conditions and organizations, process and service delivery system and stage of development. This will allow to transfer and mainstream the service delivery system to different EU contexts and agencies.

Keywords: social innovation,open innovation,social economy,social impact,theory of change,peer to peer learning,international networking
Interactions of amyloid peptides with the neuronal membrane interface: molecular mechanisms involved in Alzheimer’s disease (AMNEsIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The neuronal membrane is the target of specific molecular interactions involved in the development of Alzheimer’s disease (AD). The 2 hallmarks of the disease, extracellular amyloid β plaques and intracellular Tau neurofibrillatory tangles, are inherently linked to the membrane, as this biointerface induces and influences amyloid fibrillation. Moreover amyloid peptides selectively interact with the membrane depending of its composition, leading to toxicity mechanisms that are still poorly understood at the molecular scale. This project aims at providing a better understanding of the toxicity mechanisms of the amyloid peptides Aβ1-42 and Tau involved in AD on the neuronal membrane. Using Atomic Force Microscopy (AFM) with Carbon NanoTube (CNT) probes, we will obtain high-resolution imaging of these interactions at the nanometer scale. A unique functionalization of CNT tips with amyloid peptides will also allow true single molecule force spectroscopy of peptide/lipid interactions, unraveling their driving forces. With a progressive increase of the complexity in our system, we will, for the first time, investigate a potential synergy between Aβ1-42 and Tau and will develop an innovative approach to study live neurons by AFM imaging and force spectroscopy. Our study will establish new powerful methods to study the interactions of peptides with membranes or cells at the nanometer scale. We will not only contribute to the understanding of the deleterious effect of amyloid peptides on the neuronal membrane interface but also to the design of efficient preventive or therapeutic treatments, still lacking today.

Keywords: alzheimer s disease,atomic force microscopy,carbon nanotubes,functionalization,biointerface,lipid membrane,amyloid peptides