Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Operando Insight into Nanoscale Electrocatalytic Interfaces for Carbon Dioxide Electrolysis (OPNANOELECTRO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Carbon dioxide (CO2) electrolysis is a promising route for converting greenhouse gases into value-added products. However, the industrial viability of CO2 electrolyzers requires significant advances in electrocatalyst design for cathode CO2 reduction reaction (CO2RR) and anode oxygen evolution reaction (OER). The major challenge lies in understanding the structure-performance relationship, which is complicated due to the unusual sensitivity of the reactivity and product selectivity to the surface structure and the change of active materials under operando conditions. The project advocates the development and innovative application of multi-microscopy, with state-of-the-art SPM as the core technology, to exclude how nanostructured heterogeneity and structural dynamics affect catalytic performance, ultimately accelerating the discovery of electrocatalysts. The research scope includes: i) identifying active sites over a heterogeneous catalyst on the nanoscale by scanning electrochemical probe microscopy (SEPM) and corelative microscopies; ii) tracking and interpreting physicochemical dynamics of active sites under reaction conditions by electrochemical atomic force microscopy (AFM) and correlative spectroelectrochemical characterization and density functional theory modeling; iii) correlating knowledge of heterogeneous and dymanics to global performance of CO2 electrolysis flow-cell via rational design of electromaterials. The proposed program combines the unique expertise of the Host group in SEPM with the Fellow's extensive knowledge in AFM, heterogeneous electrocatalysis and nanoscience to create new paradigms that will advance electrocatalysis and energy fields. The Host group's support will enable the Fellow to develop valuable skills and establish a robust academic network, enhancing her career prospects.

Keywords: scanning probe microscopy nanoscience nanoscale electrochemical mapping electrified interfaces interfacial dynamics structure performance relationships electrocatalysis co2 electrolysis
Building knowledge and tools to advance on promoting of freshwater urban ecosystems as nature based-solution for health and wellbeing in a changing word (StreamScape)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-01-15
End date: 2026-01-14
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 2
Project status: CLOSED

Cities around the world are undergoing significant transformations and are facing substantial challenges in the form of urban of climate change and ongoing urbanisation. The idea that we can work with nature to improve our cities is now seen as vital. The concept of Nature-Based Solutions has emerged to foster sustainable development by transversally addressing social, economic, and environmental urban challenges. Although the attention to nature-based solutions inclusion is an important pillar of urban sustainability, a clear understanding how they can be implemented in the freshwater landscape, is still missing, even in face of the relevance of the urban freshwaters to wellbeing of the population. This investigation aims to fill this gap, by analysing the social and environmental impacts of urban streams as important nature-based solutions from protecting water quality to reducing natural hazards while preserving biodiversity and providing health and wellbeing benefits to population. By selecting as case studies Aveiro and Coimbra, the research project aims to promote the urban streams and their multiple ecosystem services as important nature-based solutions to mitigate the effects of urbanization and climate change on aquatic ecosystems, in the human health and in the wellbeing of the population. The project will adopt the research strategies: to assess how urban development affect a capacity of urban streams to provide ecosystem services using well-established scientific methods and investigate how the degradation of urban streams reflects on the local residents’ perception of the ecosystem services in terms of benefits, health and wellbeing. In addition, thematic maps of ecosystem services identified in the urban streams will be produced to demonstrate the relevance of urban streams for ecological, cultural and social aspects and to demonstrate can this information can be useful to urban planning and governance.

Keywords: urban water ecosystem services stream ecology,environmental change nature based solutions people wellbeing
Next Generation AI Researchers for Air Quality Excellence (NextAIRE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Croatia,Belgium,Bosnia and Herzegovina,Greece,Lithuania,Austria,Finland
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 2998872.5
EU funding (EUR): 2998872.5
Participants: 16
Project status: SIGNED

NextAIRE is focused on boosting the interoperability, expanding expertise and providing a more balanced geographical and cross-sectoral circulation of European R&I talents in the field of air quality monitoring, actively involving environmental scientists, experts in hardware and Internet of Things (IoT) and machine learning engineers. The project is centred around a cross-sectoral and cross-country approach, with a strong focus on Widening countries. The training methodology, including 40 planned secondments and numerous collaboration activities, such as buddy systems, workshops, hackathons and ongoing assessment, is expected to drive sensor development and environment-related public health findings. The project is made up of 16 partners forming a highly interdisciplinary consortium with numerous SME-sized hardware producers. From a scientific perspective, air quality monitoring through low-cost sensorics and artificial intelligence is at the project's core. However, NextAIRE will use these topics to provide R&I talents hands-on experiences to increase their research, entrepreneurial and other transferable skills, strengthening the R&I human capital base and improving the excellence of the research carried out in Widening countries and beyond. NextAIRE will also generate outcomes that will positively impact the employability and sustainable career prospects for European R&I talents in the field of air quality monitoring, in both the academic and non-academic sectors alike. Results such as the NextAIRE Competency framework, mathematical and AI models and an e-learning platform featuring training materials on topics such as AI, data science and air pollution research, will help to achieve this goal.

Keywords: artificial intelligence,machine learning,air pollution,air quality,particulate matter,talents,learning
HUMAN-BASED ADVANCED CARDIAC SAFETY PLATFORM INTEGRATING MULTILAYER CARDIAC ORGANOIDS, MESH MEA, AND AI-BASED PROARRHYTHMIA RISK ASSESSMENT (HEARTCORE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Italy,Spain
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-06-01
End date: 2030-05-31
Duration (months): 48.0
Total project cost (EUR): 2993436.25
EU funding (EUR): 2993436.0
Participants: 5
Project status: SIGNED

Cardiac safety testing still relies on animal models or oversimplified in vitro assays that often fail to predict human outcomes, increasing the risk of drug-induced arrhythmias and delaying drug development. HEARTCORE will integrate physiologically relevant, human heart-forming organoids (HFOs) with a multilayer 3D mesh microelectrode array (mesh MEA) and laser-based optoporation, creating a groundbreaking new platform for cardiotoxicity testing and predicting drug responses in the short and long term. A hiPSC-derived advanced HFO model will include a proper cardiac structure of endocardial, myocardial, and epicardial compartments, including sinoatrial node–like cells for replicating 3D electrophysiological properties of the heart. These organoids will be grown into a biocompatible double-layer mesh MEA to enable non-invasive, high-resolution field-potential recordings, spatial repolarization mapping, and 3D signal propagation analysis over time. Optoporation will provide intracellular-like action potentials, while simultaneous calcium imaging and contraction monitoring will yield multiparametric datasets. To translate the data into actionable insights, we will develop a multi-scale in silico model, merging 3D spatial and temporal electrophysiological signatures with drug-specific effects to simulate proarrhythmic risk and deliver mechanistic predictions beyond current methods. For elevated throughput screening, HEARTCORE will feature an optoporation-compatible high-electrode count MEA system with >1,000 channels in multiwell plates for 3D data acquisition and visualisation across the two mesh layers. Advanced software will create authentic 3D electrophysiological maps, overcoming the limitations of current 2D views. HEARTCORE aims to transform cardiac safety testing—improving risk detection, advancing patient-specific disease modeling, cutting drug development costs, and promoting human-relevant, animal-free in vitro models emulating native-like responses.

Keywords: mea cardiac organoids human pluripotent stem cells proarrhythmia risk assessment electrophysiology microelectrode in silico 3d models disease model drug screening optoporation
Holographic Assembler for 3D Cell Cultures (HOLOCELL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cell cultures are essential for biomedical research and drug screening. The environment and the arrangement directly affect cell function. It has become clear that biological cells behave differently when cultured on a surface as opposed to a 3D environment. This discrepancy between 2D in vitro studies and the 3D environment found in vivo is critical for cancer research, most notably patient-specific therapy and high-throughput drug screening and discovery. Almost 90% of all drug candidates fail during the trial phases and one of the main reasons identified is the low physiological relevance of 2D cell cultures. Technologies are needed that enable the fast and efficient culturing of 3D cell assemblies with high repeatability and control over size and morphology. Here, we use our recently developed technology and fabrication know-how together with the expertise from our ERC-funded research to realize the first 3D bioassembler where the shape of the cell aggregates can be precisely defined by the user. Within this ERC-POC grant we plan to develop a fully operational, stand-alone benchtop bioassembler that instantly aggregates biological cells, spheroids, particles or hydrogel capsules into fully defined 3D structures using acoustic holography. Our device will be an easy-to-use and affordable instrument that is fully compatible with established biological procedures and laboratory equipment and which allows scientists to culture the specific cell structures they need. The grant will allow us to protect our know-how, identify further markets, and develop a commercialization strategy for our technology. Overall, this project will generate the first 3D cell assembler that permits the generation of user-defined cell spheroids and custom shapes at a press of button and thus presents an innovation with a sizeable market potential.
TRIAD: Enhancing Synergism on Telomere Function in Health and Disease (TRIAD)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Greece,Czechia,Portugal
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 1200000.0
EU funding (EUR): 1200000.0
Participants: 4
Project status: SIGNED

Over the years, the EU investments, i.e., ERDF and RRF, have played a crucial role in advancing biomedical research in underperforming EU Member States. However, in competitive research fields, ERDF/RRF-funded labs face significant challenges, including mismatches between regional and European approaches, disparities between Horizon thematic priorities and national/regional smart specialization strategies, as well as variations in funding allocation between consortia and single beneficiaries. The absence of coherent internationalization strategies, limited training programs and skilled personnel, fragmented research endeavors, and funding constraints further hinder the development of sustainable research synergies with leading research institutes. To address this pressing need, we propose TRIAD, a program utilizing the upstream synergy model under pathway A to enhance collaboration among three ERDF-funded labs in Greece, Portugal, and the Czech Republic with a scientific focus on the functional role of telomeres in health and disease. Leveraging ERDF funding, the three research teams have developed complementary expertise in research tools, platforms, and approaches at a regional level. The core objective of TRIAD is to enable the individual ERDF beneficiaries to overcome isolation through cross-border collaboration and successful participation in Horizon Europe calls. This will be achieved through a comprehensive collaborative strategy to share methodologies, an extensive human resources development plan, a set of activities to enhance innovation capacity and improve access to European R&I networks, as well as to increase competitiveness in research funding, and establish effective management and administrative structures on site. We anticipate that this strategy will establish a lasting legacy benefiting ERDF beneficiaries and the wider community by fostering a collaborative ecosystem that will extend well beyond the project's duration.

Keywords: dna damage,aging,telomere
A strategy for the deconstruction and functionalization of saturated nitrogen heterocycles using boryl radical reactivity (DECONSTRUCT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Cyclic amines are high-value molecules found in both natural products (alkaloids, proline…) and small-molecule therapeutics. The development of strategies for the selective and divergent functionalization of these derivatives can provide new opportunities for the discovery and evolution of materials of high relevance to our society. In general, cyclic amines are functionalised by introduction of new functionalities in place of C–H bonds. In this work we propose a fundamentally novel way to modify amines by means of radical deconstruction and tandem functionalization. This strategy will convert these cyclic materials into acyclic ones and further introduce additional substituents. The chemistry will involve amine activation by simple coordination with BH3. This will enable access to a boryl radical that can undergo e fast fragmentation followed by a radical functionalization process. Overall, this strategy will constitute a divergent platform for the diversification of high-value amines and also a novel retrosynthetic tactic for the preparation of acyclic derivatives. This research squarely fits within the expertise of the Leonori group in the generation and use of boryl radicals in synthesis and catalysis. The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance the Researcher future career following the training plan envisioned.

Keywords: boryl radical,radical ring opening,copper catalysis,cross couplings
Curating, Replicating, Orchestrating, and Propogating Citizen Science across Europe (CROPS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Portugal,United Kingdom,Austria,Spain,Italy,Belgium
Call: Laying the groundwork towards Europe-wide citizen science campaigns (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1485625.0
EU funding (EUR): 1485625.0
Participants: 6
Project status: SIGNED

In the past decade, citizen science has become a proven and accepted methodology across a wide range of scientific disciplines, able to collect new and complementary data which both enhances and adds context to existing data collection methods. By upscaling to a transnational level, citizen science could collect, analyse and exploit a vast amount of data across the ERA and beyond, achieving a higher impact through creating a multinational community of citizen scientists. However, many citizen science initiatives start at a small-scale, facing technical, practical and conceptual changes when attempting to upscale to a wider level, with current EU mechanisms and other networks not providing the support, coordination or resources required to assist their effort. CROPS aspires to inform and evolve the EU Research & Innovation system so that it can adequately support the transition of citizen science from small-scale to a Europe-wide level, moving it towards a modern, open-science approach. It will identify the most suitable citizen science initiatives for upscaling to the Europe-wide level, and in doing so will develop protocols, resources and examples of best practice for the upscaling of citizen science activities, helping practitioners to fully realise the potential impact of their activities towards the Horizon Europe EU Missions. This support will be tailored to all different types of citizen science, and the different stakeholders that are involved and participation taken.

Keywords: citizen science,transnational,sustainability,interoperability,support
A pan-European network of gender-conscious investors to support female-led companies for growth and sustainability (HER FUND)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Slovakia,France,Portugal,Ireland,Greece,Bulgaria,Denmark
Call: Expanding Investments Ecosystems (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2024-03-01
End date: 2026-03-31
Duration (months): 25.0
Total project cost (EUR): 1258657.68
EU funding (EUR): 999989.75
Participants: 10
Project status: SIGNED

European innovation performance continues to increase, yet inequalities, particularly in access to investment, are still noteworthy. There is a need to close the performance gaps, which are still visible between Strong Innovators (North and West EU) and Moderate and Emerging Innovators (South and East EU mostly). A major asset to successful and sustainable business growth relies upon awareness and strong communication between innovative sectors and investors on available resources, their access and interventions by public/private funders. Improving networking between innovation ecosystems is key to the success of growing businesses and driving continued economic development. HER FUND’s ambition is to foster knowledge-sharing and synergies between innovation actors, existing initiatives/projects in order to support the next generation of startups, with an emphasis on women-led companies and gender-conscious investors. These interactions will notably lead to best practices’ identification, capacity-building activities and guidelines. Strengthening and broadening an interregional collaboration hub will promote a more competitive EU and a more sustainable, inclusive, diverse and resilient world. This will be done in a community-driven, cross-functional, cross-sectoral, multiplier based way, with partners bringing together communities of experts from different deep-tech sectors from around Europe and beyond. HER FUND will 1) transform less connected territories into recognized and attractive innovation valleys that pool and reward investments, 2) create bridges between EU innovation ecosystems increasing access to capital and investment in less connected innovation ecosystems and allowing local start-ups benefiting from foreign investments, 3) raise the number of gender conscious investors in Europe for support to women-led companies, 4) boost women entrepreneurship, especially in Moderate and Emerging Innovators offering them access to more funding opportunities

Keywords: women entrepreneurship women led companies