Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Comprehensive Supramolecular Approach for an RNA vaccine for Influenza A (H1N1) (SupraRNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

*The development of vaccines is key for disease prevention, and is a major focus globally in the healthcare sector. Seasonal influenza is an acute respiratory infection caused by influenza viruses which circulate in all parts of the world. Seasonally, it remains a persistent health threat and has been declared an epidemic in some states. Typical vaccines have been less effective against rapidly evolving pathogens such as influenza. A new class of vaccines based on nucleic acids, namely RNA, have recently been developed and show immense promise due to their robust nature, short manufacturing times and enhanced efficacy. Here we propose an RNA delivery system based on a supramolecular assembly approach for the vaccination of influenza A H1N1 strain. Specifically, a π-amphiphile will be used as the platform molecule for covalent RNA conjugation and delivery. A messenger RNA (mRNA) targeting the hemagglutinin (HA) gene from a model influenza virus strain will be employed as the therapeutic (H1N1/PR8-HA). The central π-amphiphile moiety will be functionalized with the mRNA strand via a redox responsive disulfide bond, and hydrophilic oligo-oxy aryl groups connected via a hydrogen bonding unit to promote self-assembly. Steric stabilization will be afforded to the surface decorated mRNA to protect from enzymatic hydrolysis in the complex biological environments, through co-assembly with an analogue π-amphiphile which has been alternatively decorated with poly(ethylene glycol) (PEG) chains. Efficient intracellular transport of the delivery vehicle to achieve optimum mRNA transfection will be achieved through the incorporation of a TAT-peptide on the PEG chain end. The therapeutic efficacy of the nanoassembly will be evaluated through transfection efficacy in macrophage cell lines. Overall, this proposal aims to lay the groundwork for extending the scope of RNA vaccines by exploring the potential of supramolecular assemblies as a delivery vector.

Keywords: rna supramolecular conjugate,tat peptide supramolecular conjugate,peg supramolecular conjugate,supramolecular co assembly,photophysical and thermodynamic property,stimuli responsive rna delivery
Development and Commercialisation of an Intelligent Wearable Platforms to Stabilise Hand Tremors in Parkinson’s Disease and Essential Tremor (GyroGlove)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 2653197.5
EU funding (EUR): 1857238.25
Participants: 1
Project status: SIGNED

GyroGlove is a wearable active device based on miniaturised gyroscopes, designed to suppress the hand tremor commonly seen in people suffering from Parkinson’s Disease (PD) or Essential Tremor (ET). With the help of Innovate UK Proof of Concept (PoC) grant we have taken the idea from very early lab simulators through to functional prototypes. These were tested on PD and ET patients in lab conditions. We were able to demonstrate a 50% reduction in tremor in half of the tests and as much as 95% in one case. GyroGlove has commenced pre-production development (as of Nov 2017). The team has achieved TRL 6 as of this application and demonstrated proof-of-concept with group patient tests (30 users). The GyroGlove form-factor comprises a lightweight/comfortable mount for an enclosed gyroscope which spins at approximately 20,000 RPM. By stabilising the hand directly, the GyroGlove is targeted at multi-function use (eating, drinking, writing, selfcare etc.) to return independence and freedom to users. Given development and user testing success thus far, the phase 2 project will enable us to: finalise engineering design specification; build functional and pre-production prototypes; transfer to manufacture; conduct clinical trials and gain regulatory approval; develop supply chain agreements and commercial contracts ready for full commercialisation and multiple-market entry in Q4 2022 .

Keywords: parkinson s disease,essential tremor,wearable devices,disease management,hand tremor
Co-ordinating and Co-designing the European Polar Research Area (EU-PolarNet 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Iceland,Spain,Italy,Germany,Switzerland,Switzerland,Türkiye,Finland,Poland,Norway,Norway,Belgium,Bulgaria,Sweden,France,France,Czechia,Netherlands,Portugal,Denmark,Faroe Islands,United Kingdom
Call: Coordination of European Polar research (H2020-LC-CLA-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3299253.75
EU funding (EUR): 3299253.75
Participants: 27
Project status: SIGNED

With communities and ecosystems subject to multiple environmental, climatic, cultural and economic stresses, the Polar Regions truly represent the sentinel of climate change. Already now, changes in the Polar Regions are changing the lives of polar residents, and are affecting the well-being of many polar communities. Furthermore, the state of the Polar systems has far reaching effects on atmosphere, ocean and land including the change of weather pattern in Europe. Polar issues have been therefore rising up the political agenda across Europe over the past decade and the European Union and its executive body, the EC, attribute an increasing importance to science and innovation in the high latitudes and are major investors in Polar research. There is therefore an increasing need to further develop the coordination of Polar research actions in Europe to give evidence-based advice to decision makers. This must include a continued involvement of all relevant stake- and right holders to develop transdisciplinary and transnational projects to tackle societally relevant problems connected to the Polar Regions. EU-PolarNet 2 will provide a coordination platform to co-develop strategies to advance the European Polar Research action and its contribution to the policy-making processes. It will operate as such a platform for the 4-years of the project´s lifetime. Once EU-PolarNet 2 ends, the gained experience, the established network and the developed tools to facilitate better coordination and co-design of Polar research actions will be transferred to the European Polar Coordination Office to be sustained. The EU-PolarNet 2 consortium consist of 25 partners representing all European and associated countries with Polar research programmes and activities. This allows EU-PolarNet 2 to significantly improve the coordination and co-design of European Polar research actions but also to provide evidence-based advice on behalf of the whole European Polar community.

Keywords: polar research coordination,european polar research area,policy advice,arctic,antarctic
Rational Design of Photoreceptor Mutants with Desired Photochemical Properties (PhotoMutant)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2021-07-31
Duration (months): 66.0
Total project cost (EUR): 1397475.0
EU funding (EUR): 1397475.0
Participants: 1
Project status: CLOSED

From a technological viewpoint photoreceptor proteins, the light-sensitive proteins involved in the sensing and response to light in a variety of organisms, represent biological light converters. Hence they are successfully utilized in a number of technological applications, e.g. the green-fluorescent protein used to visualize spatial and temporal information in cells. However, despite the ground-breaking nature of this utilization in life science and other disciplines, the attempts to design a photoreceptor for a particular application by protein mutation remains an open challenge. This is exactly the scope of my research proposal: the application of multi-scale modelling for the systematic design of biological photoreceptor mutants. With this target in mind I will study representatives of two prominent photoreceptor proteins subfamilies which are of towering interest to experimentalists: proteorhodopsins and cyanobacteriochromes. Computer models of these proteins will be constructed using accurate multi-scale modeling. Their excitation energies and other properties (e.g. excited-state reactivity and efficiency) will be calculated using multireference methods that were shown to have an accuracy of <3 kcal/mol. The insights gained from simulations of the wild-type proteins will provide the basis for proposing mutations with altered photochemical properties: in essence to predict absorption and emission spectra, excited-state lifetime and quantum yields. This research requires interactions across the disciplines, as the best candidates will be synthesized and characterized experimentally by collaborators. The outcome of these experiments will provide feedback to improve both the properties of the mutants and the simulation methodology. Ultimately this high-risk/high gain project should derive a comprehensive understanding that would result in novel biotechnological applications, e.g. optogenetic tools, fluorescent probes and biosensors.

Keywords: excited states,photochemistry,photobiology,multiscale modeling,simulations
Writing on Air: Radio and Northern Irish Writers, 1966–1986 (RadNIW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2025-02-28
Duration (months): 33.0
Total project cost (EUR): 251074.56
EU funding (EUR): 251074.56
Participants: 2
Project status: SIGNED

Northern Ireland from the mid-1960s to late-1980s was marked not only by sectarian conflict, but an extraordinary flowering of literary talent. Set against the backdrop of the Troubles, the origin story of this generation of Northern writers often referred to as the ‘Belfast Group’ – Seamus Heaney, Paul Muldoon, Derek Mahon, and Michael Longley among them – has been told and retold by academics, journalists, and the poets themselves over the last fifty years. But the role radio played in facilitating their spectacular rise has been almost entirely overlooked. In this project, the ER will develop a new interdisciplinary approach that combines broadcast media, cultural history, artistic collaboration, and literary analysis to re-evaluate the careers of these Northern Irish writers through their formative engagements with radio broadcasting. The BBC Northern Ireland Community Archive alone contains 110 Arts programmes from 1973–1986 involving multiple members of the Belfast Group. Using sources from the BBC, RTÉ, and Emory University archives, this project will explore little-known radio scripts, talks, correspondence, and creative collaborations between these Northern Irish writers in order to shed new light on the published work that made their reputations. The ER will have a monograph fully drafted by the end of the fellowship. In collaboration of with Emory University, the ER will host an international symposium and will produce a free-to-use online database of the radio materials being held in archives across the UK, Ireland, and USA. This database be an invaluable resource, helping to address the problems of access and visibility that have made it difficult for researchers to tackle this important radio material. As well as opening up the productive relationship between radio broadcasting and the arts, the action will help us to better understand the social dynamics of creativity within literary groups and the public face of poetry in an age of mass media.

Keywords: radio,northern irish poetry,artistic collaboration,production networks,broadcasting archives,cultural history,the troubles,regional identity
RESilience to Early Developmental Adversity: can children's environment help them overcome the odds? (RESEDA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1541617.0
EU funding (EUR): 1541617.0
Participants: 1
Project status: SIGNED

Socioeconomic inequalities in children’s neurodevelopment and mental health are observed from early onwards and widen over time. Moreover, children whose parents are immigrant, particularly if they belong to ethnic minority groups, may be especially vulnerable. Yet there are important inter-individual differences in development, implying the possibility of resilience. My project will examine the consequences of multiple forms of socioeconomic adversity in children’s family and broader social environment with regard to their neurodevelopment and mental health, testing the role of social supports as sources of resilience. Specifically, I will rely upon longitudinal data collected from the ELFE child cohort study, a nationally representative sample of 18 321 children born in France in 2011 and followed-up to age 10.5 years, which will be linked with longitudinal administrative and geographical information characterizing neighbourhoods of children’s school and residence, as well as healthcare use data. Potential resilience factors will include familial (e.g. relations between the child and his/her mother and father, grandparents’ involvement) and contextual social supports (e.g. childcare prior to school entry, neighborhood social capital). Lifecourse patterns of adversity and resilience at each level of analysis will be identified using statistical methods developed for high-dimensional data and their influence on children’s development will be ascertained applying methods that strengthen causal inference (e.g. propensity scores). The results will help clarify 1) the ways in which lifecourse patterns of exposure to adversity in the family and children’s broader social environment can influence neurodevelopment and mental health, particularly among children of immigrants; 2) familial and collective factors that can help children overcome the odds and should be promoted.

Keywords: migration,children,resilience,neurodevelopment,mental health
Support the coordination of cities’ activities via the Green Digital Charter (GuiDanCe)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Belgium
Call: Energy (H2020-Adhoc-2014-20, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 603687.5
EU funding (EUR): 499750.0
Participants: 1
Project status: CLOSED

The Green Digital Charter is a EUROCITIES response, initiated by Clicks and Links Ltd and the City of Manchester, as part of a ‘Greenshift’ initiative. It has been realised through the work of the EUROCITIES Knowledge Society Forum (KSF) Working Group on ICT for Energy Efficiency, led by the City of Manchester. It was built on ICT-enabled sustainability initiatives like "Smart 2020," with Global e-sustainability initiative and the Climate Group, and "ICT4EE" with the European Commission. From September 2011 to May 2014, European Commission awarded the FP7-NiCE project grant to provide a platform for action based on the Green Digital Charter. Following the first five years of promoting and working with the Green Digital Charter as well as the conclusion of NiCE project, GuiDanCe will build on the outcomes of NiCE and address the identified challenges that need to be further tackled. The aim of GuiDanCe project is “to provide GuiDanCe and support cities’ activities towards their Green Digital charter commitments so that they eventually take ownership of the Charter”. The project will work for three main objectives: 1. Strengthen the engagement of GDC signatories to create a club of cities that work together towards their GDC commitments 2. Improve existing tools and services and their impact to GDC signatories 3. Promote GDC signatories’ activities in and outside the EU The GuiDanCe project addresses the work programme topic “Support the coordination of cities' activities via the Green Digital Charter” and will be coordinated by EUROCITIES, a network of over 140 major European cities.

Keywords: green digital charter,energy efficiency,smart cities,eu china,cities
International Development of gAnil-spirAL2 (IDEAAL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Poland,France,France,France
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-03-31
Duration (months): 51.0
Total project cost (EUR): 3883390.0
EU funding (EUR): 3883390.0
Participants: 6
Project status: CLOSED

The objectives of the IDEAAL Project are to explore all possibilities to develop GANIL infrastructure, with its new ESFRI SPIRAL2 facility, in order to ensure its long-term sustainability as one of the premiere European research institutes for nuclear physics, interdisciplinary sciences and related applications. The first objective of the IDEAAL Project is to enlarge the present GANIL membership to include academic institutions and private funding partners. This enlargement goes hand-in-hand with a reinforcement of the involvement of the current institutional funders and academic users of GANIL-SPIRAL2 in the decision-making process and management of the facility. The second objective of IDEAAL is to enhance the excellence of access to the infrastructure by optimizing support to the users, access policy, assessment on the cost of access to the facilities and to data, improvement of the performance capabilities as well as exchange and training of personnel with associated partners. Innovation is the third objective of IDEAAL. With the new facility SPIRAL2, it is essential to encourage industrial users of the uniqueness of this new machine for their research and applications and to allow them to develop new experimental tools at the existing GANIL facilities. Access provision dedicated to industrial users will greatly enhance their experience and increase their interest and trust in GANIL-SPIRAL2. In parallel, new ideas and topics for technology transfer will be clearly identified. The increase of innovation potential of GANIL will also be evaluated. These three objectives must be supported by a strong communication and outreach policy towards members and funding partners, users and the layman. This is the fourth objective of the project. Fulfilling all of these four objectives will allow a well-organized, highly efficient and sustainable development of the current GANIL structure.

Keywords: nuclear physics,interdisciplinary research,international infrastructure
Self-healing, Multifunctional, Advanced Repair Technologies IN Cementitious Systems (SMARTINCS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Spain,Spain,Belgium,Belgium,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-12-01
End date: 2024-05-31
Duration (months): 54.0
Total project cost (EUR): 4030444.44
EU funding (EUR): 4030444.44
Participants: 11
Project status: SIGNED

SMARTINCS will train a new generation of entrepreneurial early-stage researchers (ESR) in prevention of deterioration of (i) new concrete infrastructure by innovative, multifunctional self-healing strategies; (ii) existing concrete infrastructure by advanced repair technologies. The project brings together the expertise of research institutes pioneering in smart cementitious materials, strengthened by leading companies along the SMARTINCS value chain, as well as certification and pre-standardization agencies. They will train 15 ESRs to respond to the clear demand to implement new life-cycle thinking and durability-based approaches to the design of concrete structures, minimizing the use of resources and production of waste in line with Europe’s Circular Economy strategy. The new generation of researchers will be immediately employable to support the introduction of the novel technologies allowing the expected spectacular growth of the self-healing materials market to take place. By combined experimental research and coupled multiscale models, SMARTINCS moves beyond the state-of-the-art with respect to (1) the efficiency of self-healing concrete, at acceptable cost for real-scale applications; (2) the multi-functionality (corrosion inhibition, self-sensing) of the self-healing solutions, tailored to specific environments; (3) the technologies for local application of healing agents in high risk zones or in high value grouts and repair products. All ESR will receive an extensive entrepreneurial training including the development of dedicated business models. Together with the implementation of self-healing technologies in design codes and service life models and a full assessment of sustainability, the introduction of the novel technologies in the market will be facilitated, improving the European innovation capacity. An adequate gender balance of supervisors and trainers, should persuade female scientists to aspire leading positions in technology and engineering.

Keywords: self healing,concrete,durable,sustainable,smart,service life,infrastructure,construction