Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technologies for the Multilingual European Information Society (T4ME NET)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Cognitive systems, interaction, robotics
Action type: Network of Excellence
Countries involved: Germany,Spain,Italy,Greece,Czechia,France,Netherlands,Finland,Ireland,Germany,Slovenia
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-02-01
End date: 2013-01-31
Duration (months): 36.0
Total project cost (EUR): 7568982.0
EU funding (EUR): 5990000.0
Participants: 14
Project status: CLOSED

Linguistic diversity is a corner stone of our multicultural European society. To preserve this essential asset in the age of the emerging information and knowledge society, Europe needs ICT technologies and applications at affordable costs that • enable communication, collaboration and participation across language boundaries • secure their language users equal access to the information and knowledge society • support each language in the advanced functionalities of networked ICT Prerequisites of these applications are advances in several fields of Human Language Technologies (HLT) such as • machine translation (MT) including automatic translation and machine assisted human translation • technologies for information and knowledge management including IR, crosslingual IR and corporate memories • technologies for document and content production and management (including authoring tools, language checking and interactive content applications) • technologies for intuitive interfaces to all types of technology (including multimodal user interfaces, speech interfaces for interactive mobile applications, robot control interfaces) Building a single EU information space reflecting and supporting the cultural diversity of our continent as an adequate foundation for the multilingual European information and knowledge society is a major challenge. Because of the complexity of human language and the number of languages to be included this challenge demands a large collective effort of research and language communities as well as several industrial sectors. T4ME shall seek progress by approaching open pro¬blems in collaboration with other research fields such as machine learning, social computing, cognitive systems, knowledge technologies and multimedia content. It shall mobilize and strengthen the European HLT community encompassing researchers, developers and language professionals through networking of research and by creating new schemes of sharing resources and efforts.

Keywords: human language technologies,translingual technologies,machine translation,crosslingual applications,language resources,multilingual european information society
Merging Plasmonic and Silicon Photonics Technology towards Tb/s routing in optical interconnects (PLATON)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Greece,Germany,Denmark,France,Germany
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2013-06-30
Duration (months): 42.0
Total project cost (EUR): 3403174.0
EU funding (EUR): 2599816.0
Participants: 6
Project status: CLOSED

PLATON aims to realize a fully integrated Tb/s optical routing system for data networks expecting to deliver important advantages to the end-users as it will enable high-speed communications and ultra-fast access to data information being stored at large computer centers whilst investing in a new technological platform of lower cost, lower power consumption and reduced size requirements. This will allow for the effective consolidation of today’s Internet and computer server rooms storing huge amounts of information into smaller-size rack- or even box-interconnect environments. PLATON’s routing fabric will employ novel plasmonic switching elements on a silicon motherboard and will develop novel fabrication processes for enabling the merger of plasmonics with silicon nanophotonics and electronics, targeting the combined utilization of small-footprint, high-bandwidth plasmonics structures with the low-loss functional potential offered by the more mature SOI technology. PLATON will evolve upon a whole new generation of miniaturized photonic components including: (a) a new series of fast 2x2 thermooptic plasmonic switches, (b) a small-footprint 4x4 thermooptic plasmonics switch, (c) an optically addressable 1x2 plasmonic switch operating at bitrates in excess of 10Gb/s, and (d) a 2x2 and a 4x4 Tb/s optical routing platforms. To this end, PLATON will pioneer the field of routing for optical interconnects and will provide a completely new technological toolkit, bringing Europe in a leading position world-wide with respect to research efforts in plasmonics for interconnects. Finally, it will open totally new application vistas and opportunities for European industry being active in the field of nanophotonics, given that the active participation of industry within PLATON ensures the industrial take up of the combined plasmonics/photonics functional devices from research elements to commercially available products.

Keywords: optical interconnects,plasmonics,high-capacity interconnect routing,dielectric loaded surface plasmon polaritons
Investigating sRNAs as the master on/off switch of Vibrio cholerae virulence (VCSRNAHV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cholera is a severe diarrhoeal disease caused by the bacterium Vibrio cholerae and is responsible for thousands of deaths worldwide every year. The current treatment is oral rehydration therapy combined with antibiotics. However, with antibiotic resistance on the rise, new antimicrobial strategies are needed to combat the disease. An attractive antimicrobial approach is to inhibit functions that are essential for bacterial virulence. This disarms the bacteria rather than killing them, reducing the selective pressure that leads to antibiotic resistance in the first place. Four small regulatory RNAs, the quorum regulatory RNAs (Qrrs), lie at the heart of the virulence pathway in V. cholerae. At low bacterial cell density, in the initial phases of infection, the Qrrs are abundant which leads to the expression of virulence genes, infection of the host and cholera. Post infection, when the cells are at high densities, Qrrs are no longer produced, which turns off virulence-gene expression and induces the release of the bacteria back into the environment for reinfection. The Qrrs function by altering the translation and/or stability of specific mRNA targets through base-pairing, which ultimately regulates the expression of the virulence genes. Artificially modulating these base-pairing interactions is key to inhibiting V. cholerae virulence. In order to do this, it is necessary to elucidate the molecular details of the interactions. How do the Qrrs bind to their mRNA-targets? Are protein partners, e.g. Hfq, required for the interaction? What are the binding parameters of the interactions? In this proposal, a range of molecular genetic, biochemical, biophysical and structural studies will be performed to investigate the interactions involved between the Qrr sRNAs, their mRNA targets and protein partners. This will provide a solid foundation for the development of a novel antimicrobial strategy for the prevention and treatment of cholera.

Keywords: molecular genetics,biochemistry,biophysics,structural biology,protein-rna interactions,srna,hfq,ribonuclease,rna degradation,rna base-pairing,bacterial virulence,antimicrobial
Game Theory: Dynamic Approaches (GAME-DYNAMICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: Israel
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-01-01
End date: 2015-12-31
Duration (months): 72.0
Total project cost (EUR): 1361000.0
EU funding (EUR): 1361000.0
Participants: 1
Project status: CLOSED

The general framework is that of game theory, with multiple participants ( players ) that interact repeatedly over time. The players may be people, corporations, nations, computers even genes. While many of the standard concepts of game theory are static by their very nature (for example, strategic equilibria and cooperative solutions), it is of utmost importance theoretically as well as in applications to study dynamic processes, and relate them to appropriate static solutions. This is a fundamental issue. On the one hand, the significance of a solution depends in particular on how easy it is to reach it. On the other hand, natural dynamics, that is, processes that to a certain degree reflect observed behaviors and actual institutions, are important to study and understand in their own right. We propose to work on three main areas. First, adaptive dynamics: the goal is to characterize those classes of dynamics for which convergence to Nash or correlated equilibria can be obtained, and those for which it cannot, and to find and study natural dynamics that are related to actual behavior and yield useful insights. Second, evolutionary dynamics: the goal is to investigate evolutionary and similar dynamics, with a particular emphasis on understanding the role that large populations may play, and on characterizing which equilibria are evolutionarily stable and which are not. Third, bargaining and cooperation: the goal is to develop a general research program that studies natural bargaining procedures that lead to cooperation and are based directly on the strategic form; some particular aims are to establish connections between the bargaining institutions and the resulting cooperative solutions, and to analyze relevant economic models.

Keywords: game theory,dynamics,adaptive,evolutionary,equilibrium,bargaining,cooperation
Pulmonary hypertension and acute lung injury: Role of sphingomyelinase in the signalling of hypoxia in pulmonary arteries. (SMASE-HPV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-12-01
End date: 2012-11-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Hypoxic pulmonary vasoconstriction (HPV) is a unique vasoconstrictor response that diverts blood flow away from poorly ventilated lung regions allowing ventilation-perfusion matching. Despite being a highly conserved adaptive physiological mechanism in lung breathing vertebrates that optimizes blood oxygen saturation, hypoxia sensing in the lung plays a critical pathophysiological role in a number of pulmonary disorders. COPD is associated with chronic hypoxia and can lead in some patients to secondary pulmonary hypertension (PH). Where COPD is confounded with PH, patients have a worse prognosis for survival. In contrast, failure of HPV is often a critical determinant of hypoxemia in sepsis- and trauma-induced lung injury, including the acute respiratory distress syndrome (ARDS). Despite intensive research in the field, the molecular bases of HPV are far from being elucidated. We have recently shown that ceramide production derived from neutral sphingomyelinase (nSMase) and subsequent activation of PKCz are early and necessary events in the signaling cascade of HPV. In sepsis/ARDS an acidic form of SMase is induced. This form can deplete the downstream signaling components of nSMase and is associated with inflammation. Inhibition of nSMase prevents HPV whilst inhibition of aSMase may prevent dysfunction associated with ARDS/sepsis. Thus, these data suggest both nSMase and aSMase are new potential therapeutic targets in the treatment of PH and ARDS/sepsis. The purpose of this application is therefore to fully investigate the role of SMase in the intracellular signaling of hypoxia and inflammation in pulmonary vessels. Secondly, I will investigate associations in SMase activity and gene polymorphisms in tissue from COPD patients with or without PH. This approach will enable us to both identify new treatment targets and potential genetic markers predictive of susceptibility to PH.

Keywords: health sciences,physiology,biological sciences,cardiovascular diseases,pulmonary circulation
Phosphate signaling in plants: dynamic study of phosphate movements and gene induction kinetics (PHOSPHEURUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Because phosphate is a major component of all cells, a deficiency in this mineral can have a dramatic impact on the physiology of any living organism. Unfortunately, we still have a very partial understanding of the signaling pathways involved in the acquisition, detection and homeostasis control of this nutrient. This project aims to increase our understanding of the mechanisms triggered by the detection of phosphate by plants. A significant technical barrier to progress in this field is the lack of technical tools allowing researchers to measure and control free phosphate fluctuations inside the cell in a precise and time-resolved manner. This project offers to develop such tools, which could be applied to the study of plants as well as to animal cells. They will allow us, along with genetical and molecular biology analyses, to progress towards the identification of new components of the phosphate detection signaling cascade. It will also help us understand how the signal can be differentially transmitted to the different tissues of the plant. This application is presented by Hélène Javot, and follows her recent arrival at the CEA-Cadarache institution (France), to work on phosphate signaling in Arabidopsis thaliana (in Laurent Nussaume’s laboratory). It is developed in close collaboration with a team of expert photo-chemists and with H. Javot previous host laboratory (Maria Harrison’s team, USA), where she worked for the past five years on the phosphate transport occurring during the symbiosis between plants and endomycorrhizal fungi. The project will fully integrate physiological analysis with state-of-the-art techniques of imaging, photochemistry and molecular biology. By pinpointing to different markers of the phosphate signaling pathway, we will provide tools for monitoring nutrient efficiency in crops and lead to innovative integrated strategies of plant production based on more efficient use of fertilizer input.

Keywords: engineering,phosphate,signaling,plant,root,imaging,photochemistry,caged-compound,nanosensor
Cryptographic Techniques for Reconciling Utility with Privacy in Computer Systems (RECUP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2011-01-01
End date: 2014-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

As the Internet and other networks become the basic infrastructure for conducting governmental, commercial and personal transactions, there are increasing amounts of sensitive data that are produced, transferred and stored in digital form. Computer services have revolutionized every aspect of human endeavour, but at the same time the current data management practices have lead to high risks of inadvertent exposure of sensitive information. Cryptographic techniques have been used successfully to secure online transactions but nevertheless they have done little to mitigate the risks of data exposure. The reason for this is that currently applied cryptographic methods do not offer a proper balance between utility and privacy for the data they secure. As a result, data utility is typically provided &quot;on top&quot; of cryptographic techniques through monolithic key-management that in the end leaves data vulnerable due to hacking incidents and chain-of-custody breakdowns. To address these issues of important concern, the University of Athens, proposes Prof. Aggelos Kiayias, a world renowned expert in the design of cryptographic systems, for a Marie Curie reintegration grant. Prof. Kiayias worked at the University of Connecticut, USA for the last six years. He built there a research group that had great impact in the area of cryptography and system security as evidenced by his record detailed in this proposal. The focus of this reintegration proposal is to enable the University of Athens to engage in the development and dissemination of a new generation of cryptographic tools that can be used to make computer systems and networks better fulfill their role as basic infrastructure carrying sensitive data. Moreover, the grant has the broader aim to impact the local IT industry by influencing its data management practices and facilitating a better opportunity for compliance with current and future privacy regulations.

Keywords: cryptography,algorithms,number theory,data privacy,security systems,trust technology
Doxorubicin-induced impairment of metabolic and stress signaling: a culprit of cardiotoxic action of the drug? (ANTHRAPLUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Anthracyclines, in particular doxorubicin, are the most effective anticancer drugs. However, their serious side effect is a cardiotoxicity, which is not entirely understood. We propose a novel hypothesis, namely that anthracycline-induced cardiac damage is related to impaired cellular responses to energy depletion, and possibly also to other forms of stress (oxidative, genotoxic), inducing a “catastrophe”, fatal for cardiac (and cancer) cells. The aim of the project is to verify this hypothesis in different models: perfused heart, cultured cardiomyocytes, and an in vivo model of cardiotoxicity newly established in our group, the doxorubicin-treated rat. Our project will integrate: (i) a non-biased phosphoproteomic approach extending our transcriptomic study and aiming at the identification of new phosphorylation events mediating response to doxorubicin; (ii) a targeted approach focusing on pathways identified by our targeted and non-biased in vitro studies, as e.g. signaling by LKB1-AMPK-mTOR, MAPK, HIF, VEGF, and NDPK, a metabolic kinase that we have recently identified as doxorubicin target. We will analyse the effects of doxorubicin on these pathways (including gene and protein expression, phosphorylation, activity) and their consequences for cardiac function, energy state, apoptotic status, and response to an additional stress (ischemia). This multidisciplinary project will combine biophysical, biochemical, molecular, physiological and systems biology (phosphoproteomics, modeling) state-of-the-art approaches. We expect to identify new signaling pathways mediating doxorubicin cardiotoxic action. Further integration of the fellow with the host will allow full valorisation of projects initiated during the present Marie-Curie Fellowship, further supervision of PhD and master students, and access to a permanent position in Grenoble at the group leader level. This would enable the fellow to pursue a dual academic career with her spouse at the same geographic location.

Keywords: cardiology,drug diseases,proteomics,bioenergetics,anthracyclines,doxorubicin,metabolism,cell signaling,stress,amp-activated protein kinase,cardiotoxicity,cardiomyopathy
Spectrum-Aware and Reliable Wireless Sensor Networks for Europe’s Future Electricity Networks and Power Systems (SA-WSN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-02
End date: 2013-11-01
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In this proposal, a Spectrum-Aware and Cross-layer Communication framework is proposed to realize efficient wireless sensor networking for currently envisioned smart grid applications. The proposed framework is a complete cross-layering such that the functionalities of traditional communication layers are melted in a customized cross-layer communication module for resource-limited sensor nodes to decrease the overhead and improve performance of traditional layered approaches. It also uses spectrum-aware spectrum access techniques to achieve a more efficient spectrum utilization by adapting to the availability of communication resources in harsh power system environments, which varies greatly with location, time and frequency because of obstructions, node contentions, RF interference and extreme noise. The specific goals of this project are: 1) Development of accurate analytical models to capture the characteristics of the wireless channel in power system environments; 2) Design of cross-layer &amp; cognitive communication solutions enabling efficient utilization of the wireless channel, thus providing researchers with building blocks to ensure QoS for the envisioned applications; 3) Experimental verification of models and protocols with field tests; 4) To bridge the performance gap between sensor networking theory and real-world smart grid deployments by using an interdisciplinary research approach and international collaborations. Overall, this project will enable the PI to advance the field of wireless sensor networking and smart electric power grid applications as well as educating and inspiring the next generation of engineers in Europe. To this end, it addresses research, educational,and community service goals of IRG FP7 Work Program. Also, this research grant will help the PI to contribute to the European utility industry’s competitiveness, success of the European host university, and to become an integral part of the European research community.

Keywords: technological sciences,wireless sensor networks