Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boundary value problems for nonlinear integrable equations (BOPNIE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2022-02-28
Duration (months): 70.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The purpose of this project is to develop new methods for solving boundary value problems (BVPs) for nonlinear integrable partial differential equations (PDEs). Integrable PDEs can be analyzed by means of the Inverse Scattering Transform, whose introduction was one of the most important developments in the theory of nonlinear PDEs in the 20th century. Until the 1990s the inverse scattering methodology was pursued almost entirely for pure initial-value problems. However, in many laboratory and field situations, the solution is generated by what corresponds to the imposition of boundary conditions rather than initial conditions. Thus, an understanding of BVPs is crucial. In an exciting sequence of events taking place in the last two decades, new tools have become available to deal with BVPs for integrable PDEs. Although some important issues have already been resolved, several major problems remain open. The aim of this project is to solve a number of these open problems and to find solutions of BVPs which were heretofore not solvable. More precisely, the proposal has eight objectives: 1. Develop methods for solving problems with time-periodic boundary conditions. 2. Answer some long-standing open questions raised by series of wave-tank experiments 35 years ago. 3. Develop a new approach for the study of space-periodic solutions. 4. Develop new approaches for the analysis of BVPs for equations with 3 x 3-matrix Lax pairs. 5. Derive new asymptotic formulas by using a nonlinear version of the steepest descent method. 6. Construct disk and disk/black-hole solutions of the stationary axisymmetric Einstein equations. 7. Solve a BVP in Einstein's theory of relativity describing two colliding gravitational waves. 8. Extend the above methods to BVPs in higher dimensions.
Engineering a Sugar-targeted Nucleic Acid delivery Polymer to understand and enhance vaccination by self-amplifying RNA (SNAP-Vax)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

I aim to expand the broad clinical potential of self-amplifying RNA (saRNA) vaccines by crafting nanomaterial formulations that will target intracellular delivery of saRNA and molecular adjuvants to the key cells that mediate immunity. Both the devastating SARS-CoV-2 pandemic and annual flu seasons expose a significant need for more rapid development of effective vaccines. Nucleic acids such as self-amplifying messenger RNA (saRNA) are an exciting new class of subunit vaccine cargoes that promise to address the need for more adaptable, scalable, and more efficacious vaccines in comparison to those rooted in laboriously produced recombinant proteins. Although saRNA-based vaccine production offers a powerful platform to address these major issues with vaccine development, there is a huge need for innovative methods that can deliver nucleic acids across the body's many physiological barriers and generate protective immunity. This project seeks to apply the materials expertise of the applicant and the Stevens group (Imperial College London [ICL]) to the improved delivery and function of first generation saRNA vaccines that have been pioneered in the Shattock group (ICL). We hypothesize that polymer nanomaterial design can enable delivery of saRNA vaccine components to key cells responsible for generating adaptive immune responses and that this "targeted" saRNA vaccine delivery will lead to enhanced protective immunity compared to current vaccines. I will apply advanced polymerization techniques to tailor the delivery of saRNA to antigen presenting cells and to master cutting-edge imaging techniques to characterize the cellular response to targeted vaccine uptake (Raman, FIB-SEM). I will then collaborate with the Shattock lab to evaluate vaccine targeting in mice in vivo and in human skin explant models ex vivo, and complete a secondment at AstraZeneca that will provide invaluable insight into translational development of nanomaterials for nucleic acid delivery.

Keywords: nucleic acid delivery,immunoengineering,rna vaccine
Innovation Denmark II (INNO DK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Denmark,Denmark,Denmark,Denmark,Denmark,Denmark
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 549828.07
EU funding (EUR): 549828.07
Participants: 10
Project status: CLOSED

The objectives of the Innovation Denmark II project are to: • Provide Key Account Management (KAM) services to Danish businesses, which have been awarded grants under the SME Instrument. • Provide Enhancing Innovation Management Capacity (EIMC) services to SMEs in 2017-2018. Companies will be assessed via the IMP3rove or Innovation Health Check tools and depending on results, referred on to relevant organisations in the Danish and European innovation eco-system. In total, under both categories, a minimum of 138 service packages will be carried out. The figure is based on an average of 69 KAM packages coming through SME Instrument, and 69 EIMC cases carried out. If a larger amount of SMEs is granted SMEI projects, the packages will be adjusted accordingly.

Keywords: innovation,key account management,key account manager,enhancing innovation management capacity,eimc,imp3rove,innovation healthcheck
Exploiting native endowments by re-factoring, re-programming and implementing novel control loops in Pseudomonas putida for bespoke biocatalysis (EmPowerPutida)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Germany,Switzerland,Netherlands,Portugal,United Kingdom,United Kingdom
Call: Synthetic biology – construction of organisms for new products and processes (H2020-LEIT-BIO-2014-1, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 6839673.0
EU funding (EUR): 6020825.0
Participants: 11
Project status: CLOSED

We aim to engineer the lifestyle of Pseudomonas putida to generate a tailored, re-factored chassis with highly attractive new-to-nature properties, thereby opening the door to the production of thus far non-accessible compounds. This industrially driven project capitalises on the outstanding metabolic endowment and stress tolerance capabilities of this versatile bacterium for the production of specialty and bulk chemicals. Specifically, we will build streamlined P. putida strains with improved ATP availability utilizing this power on demand, decoupled from growth. The well-characterized, streamlined and re-factored strain platform will offer easy-to-use plug-in opportunities for novel, DNA-encoded functions under the control of orthogonal regulatory systems. To this end, we will deploy a concerted approach of genome refactoring, model-driven circuit design, implementation of ATP control loops, structured modelling and metabolic engineering. By drawing on a starkly improved, growth-uncoupled ATP-biosynthetic machinery, empowered P. putida strains will be able to produce a) n-butanol and isobutanol and their challenging gaseous derivatives 1-butene (BE) and (iso-)butadiene (BDE) using a novel, new-to-nature route starting from glucose, as well as b) new active ingredients for crop protection, such as tabtoxin, a high-value, ß-lactam-based secondary metabolite with a huge potential as a new herbicide. The game-changing innovations brought in – in particular the uncoupling of ATP-synthesis and production from growth - will provide strong versatility, enhanced efficiency and efficacy to the production processes, thereby overcoming current bottlenecks, matching market needs and fostering high-level research growth and development.

Keywords: biocatalysis,metabolic engineering,re programming,genome engineering,re factoring,bulk and fine chemicals,pseudomonas putida
Towards Transnational Labour Rights? Temporary Work Agencies and Third Country National Workers in the EU. (RightsLab)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-11
End date: 2024-01-10
Duration (months): 36.0
Total project cost (EUR): 275209.92
EU funding (EUR): 275209.92
Participants: 1
Project status: SIGNED

The last two decades have seen the EU grappling with a direct conflict of interests; the securitization of its external borders and the demand for a low-cost flexible workforce which in various sectors of the economy, has been increasingly occupied by migrants. Employment of third country nationals (TCNs) through temporary work agencies (TWAs) became a common solution to allow for the smooth supply of workers both in core EU member states, and in Central and Eastern Europe (CEE) region, which is in itself effected by considerable emigration and labour mobility. RightsLab will look into the employment conditions of transnational workers employed through TWAs and ask: how can we develop mechanisms of effective transnational labour rights protection for agency workers? It will provide empirically grounded research into the employment of Ukrainian workers in two CEE countries – Poland and Hungary plus Italy. Both Poland and Hungary, recently has become a laboratory for TWA forms of flexible employment, and Ukrainians represent a large segment of the TCN workers there. Italy – a key destination country for Ukrainian migrants since the late 1990s – offers an important perspective into female employment.The novelty of RightsLab’s contribution is threefold; 1) existing research on the TWAs predominantly focuses on registering labour rights violations: RightsLab makes a step further by exploring the possibilities of creating better mechanisms for cross-border labour rights protection; 2) methodologically, RightsLab combines several qualitative methods, and takes an engaged, participatory stance, actively searching and connecting various participants of the research for a possible social dialogue; 3) by focusing on various levels (national ( labour inspectorates), meso (trade unions, workers’ associations, NGOs) and local (TWAs and workers themselves)) it provides a multidimensional picture of emerging transnational employment regimes and transitional labour struggles.

Keywords: transnational labour rights,labour mobility,temporary work agencies,solidarity and mobilization,action research,gendered employment and mobility,social meaning of work,worker s agency
Iron as a driver of fibrosis and regeneration (IRONAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-05-26
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

I have worked over the last five years on understanding how ion channels control inflammation, immunity, metabolism and cancer, with a strong emphasis on Ca2+ signaling. Now, I would like to take advantage of my diverse background in cation signaling and inflammation and integrate it with the outstanding expertise of Manuel Serrano´s lab in regeneration and aging, to ask fundamental questions on the role of iron in regulation of plasticity and fibrosis. Clinical reports have described local deposition of iron around fibrotic tissues, although the significance of this remains poorly understood and unexplored. My unifying hypothesis is that fibrosis is the manifestations of ongoing free-iron release into injured organs and tissues, which without clearance maintains chronic inflammation and prevents regeneration. The project is divided as follows: Objective #1 – Iron induced inflammation: the impact of free-iron on inflammatory cytokine and chemokine expression and signaling pathways. I have preliminary data indicating that free-iron is a potent inducer of inflammatory cytokines in fibroblasts. Objective #2 – Free-iron as a causative of fibrosis: effect of iron on cellular senescence and on mouse models of fibrosis; and iron homeostasis in human patients with fibrosis. In vitro, I have found that free-iron is an inducer of senescence. Furthermore, in a pilot study, I have found that bleomycin-induced lung fibrosis in mice is accompanied by high levels of iron deposition. Objective #3: Iron clearance and regeneration: Effects of free-iron and iron induced cytokines on acquired plasticity in vitro and on wound healing. Surprisingly, my preliminary data indicate that chelation of free-iron completely blocks acquisition of pluripotency, but has no effect on expansion of stem cells. I anticipate that the completion of this action will yield new fundamental insights into the underlying mechanisms of fibrosis and regeneration, and will allow me the transit to independence.

Keywords: iron,fibrosis,regeneration,inflammation,aging,induced pluripotency,wound healing
SUSTAINABLE ECOSYSTEM FOR THE ADOPTION, RAMP-UP AND TRANSFER OF EMERGING ELECTRONICS SOLUTIONS (SmartEEs2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Belgium,Finland,Belgium,France,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Smart Anything Everywhere (H2020-DT-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 8459478.75
EU funding (EUR): 7999466.25
Participants: 15
Project status: SIGNED

Despite significant recent progress made by the EU industry, the level of digitalisation of industry remains uneven, depending on the sector, country and company size. Facing at the same time a scattered landscape of Research, Industry and Institutional stakeholders, the efficient adoption and transformation of enabling technologies into business visions & concrete market cases remain limited. This slow diffusion of digital technologies poses a risk to the EU’s ability to compete in the global economy. This is particularly true for Organic Large Area Electronics (OLAE) enabling technologies whose industry made significant progress recently and has established itself as a competitive growth industry. Despite proving that more and more products have matured onto the global market, the actual diffusion and efficient adoption of OLAE technologies remain limited. Underlying reasons and key challenges are identified (cost, processes, encapsulation, scalability, yield, standards & regulations), for which major breakthroughs are needed on use, production and cost rather than on basic technology, which reflects the growing market orientation of OLAE. To address both market & technology specific challenges, SmartEEs2 will be key role to link technology promises with real use/business cases. These cases will be implemented through a unique digitalisation experience providing experimentation, testing or support to manufacturing. SmartEEs2 will capitalize upon SmartEEs’ strong technological OLAE platform and focuss on the uptake of Flexible & Wearable Electronics enabling use cases, where OLAE can valorize its uniqueness (flexibility, conformability) and its promises for solutions in the fast growing business of wearables and Internet of Everything. SmartEEs2 will orchestrate a pan-EU collaboration network of Regional DIHs promoting the best quality level of digitalisation experience, hence boosting the efficiency and effectiveness of the overall OLAE European inDIH on Area3

Keywords: structural electronics,flexible and wearable electronics,digital innovation hub
SHAring Researchers’ Passion for Excellence and Results. European Reserarchers' Night in the Centre of Italy 2014 - 2015 (SHARPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 332065.0
EU funding (EUR): 249050.0
Participants: 5
Project status: CLOSED

The SHARPER project (Sharing Researchers’ Passion for Excellence and Results - The European Researchers’ Night in the Centre of Italy, 2014 – 2015) wants to make the researchers’ quest for excellence accessible to everybody in cities and communities where researchers act and live. Excellence is one of the main goal that researchers aim at through high level research projects that can generate innovative results. Enthusiasm, emotions and knowledge are the driving force leading researchers constantly to face new challenges. Making this process accessible means to share with people this quest for innovative results. SHARPER will take place on 26th of September 2014 and the 25th of September 2015 simultaneously in Perugia, Ancona and L’Aquila, the capital cities of three regions in the centre of Italy: Umbria, Marche and Abruzzo. The network of cities together with their Research Institutions and science communication teams provides a group of excellence at national and international level. Perugia combines its tradition as University city with the presence in the city of a fifteen years experienced team (Psiquadro) of science communicators with a European profile. In L’Aquila, The Laboratori Nazionali del Gran Sasso (LNGS), of the Italian Institute for Nuclear Physics, the University and the GSSI (Gran Sasso Science Institute) provide examples of world leading researchers teams. The Università Politecnica of Ancona is a growing Institution in the field of technological applications of research. SHARPER will include: street labs, exhibitions, performances or other communication actions in venues plenty of symbolic and practical value for the future development of the cities and their future based on excellence and innovation. The SHARPER communication actions will engage students, family groups and citizens actively involved since the planning phase of the project. At least 20.000 visitors are expected in the three cities each year during the Night.

Keywords: excellence passion emotion enthusiasm night knowledge accessibility cities fun young engagement sharing innovation italy future workshop games show street public challenge carousel social researchers
Fostering the PAN-European infrastructure for empowering SMEs digital competences in laser-based advance and additive manufacturing. (PULSATE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Norway,Norway,Lithuania,Poland,France,United Kingdom
Call: I4MS (phase 4) - uptake of digital game changers (H2020-DT-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 8127492.5
EU funding (EUR): 7999272.0
Participants: 12
Project status: SIGNED

Digitizing European industry is essential for European competitivity in the 21st century, but only 1/5 of EU SMEs is highly digitised. Laser Based Advanced and Additive Manufacturing (LBAAM) technologies are regarded as Key Enablers for Digital Production and offer important advantages to the adopters. SMEs have strong entry barriers for the technology: Investment cost, technology complexity, system integration and awareness/adoption readiness. PULSATE aims to lower all said barriers to boost the adoption of Laser Based technologies by SMEs and promote the development of SME-friendly laser based equipment and solutions. PULSATE will establish a Pan-European Network to stimulate SMEs to take part in Innovation Ecosystem of LBAAM, by connecting Digital Innovation Hubs (DIHs) to a support structure of knowledge, infrastructure and services, designed to tackle the issues currently limiting the adoption of LBAAM technology. A balanced combination is proposed between wide outreach using interconnected Virtual Communities and ICT tools (a Single Entry Point will connect a wide range of networking and servicing tools), and close exchange and interaction via DIHs. The project relies on a consortium of 6 competence centres (AIMEN, FTMC, MTC, SINTEF, Fraunhofer, CEA), service community and marketplace providers (FBA, CLESGO) and a photonics industry association (EPIC). With >50 previous projects outcomes, existing tools and services, connections with 74 running DIHs, Clusters and regional initiatives, PULSATE counts with the explicit support of companies and institutions (>80LoS), and an independent Board of Stakeholders gathering key players in LBAAM will ensure the quality and pertinence of PULSATE orientation. PULSATE will operate under 4 action areas: Business, Technology, Competence & Awareness, addressing the following technology domains: Nano/Micro Fabrication, AM, High Power Laser Manufacturing and Digitisation, and implementing 4 Open Calls and a catalogue of services.

Keywords: laser based equipment,advanced and additive manufacturing,digitization,dihs pan european network,digital agora,single entry point,open calls,i4ms,digital single market,market place,communities