Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
POLYmer based electro-optic PCB motherboard integration with Si3N4 Chiplets, InP Components and Electronic ICs enabling affordable photonic modules for THz Sensing and quantum computing applications (POLYNICES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Greece,Germany,Netherlands,Spain
Call: Advanced Photonic Integrated Circuits (Photonics Partnership) (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4963702.0
EU funding (EUR): 4963701.75
Participants: 8
Project status: SIGNED

Despite the significant advances that photonic integrated circuits (PICs) offer in terms of miniaturization, power consumption and functionalities, they run into scalability and cost issues, related to the fabrication yield, the increased integration and packaging complexity, the lack of wafer scale compatible processes and the lack of integration and packaging standards. Furthermore, so far photonic packaging considered the sub-GHz electrical connections to the PICs as a separate and second priority issue, until the number of electrical IOs of the PICs was too large to ignore. POLYNICES aims to address these challenges with the development of a novel general purpose photonic integration technology, compatible with wafer scale processes that will reduce the production costs of photonic modules by at least 10x. POLYNICES will develop for the first time a polymer based Electro-Optic PCB (EOPCB) motherboard that will host Si3N4 chiplets, InP components and micro-optical elements. POLYNICES invests in Si3N4 platform with PZT actuators to realize complex structures in only 1x1 cm2 chiplets with ultra-low power consumption. The chiplets’ grid array electrical pads and the use of flip-chip integration on vertical alignment stops will allow optical alignment and electrical connection in one step. The standard size and interfaces of the chiplets as well as the electronic IC co-packaging on the same EOPCB, provides excellent scalability and customization, and significantly simplifies packaging. Dielectric rod THz antennas will be integrated on the EOPCB taking advantage of its good HF properties. Using the above novel concepts and building blocks, POLYNICES will develop a fully integrated optoelectronic FMCW THz spectrometer with THz antenna array and beam steering abilities for quality control in plastics, a 16x16 quantum processor with integrated 780 nm light source and non-linear crystals and a 24x24 quantum processor with integrated squeezed light state source.

Keywords: electro optic pcbs,optical polymers,silicon nitride,optoelectronic thz spectrometer,photonic quantum processor,photonic packaging,flip chip integration,integrated external cavity lasers
Quorum sensing as a tool to detect and target pro-oncogenic microbial biofilms associated with right-sided colorectal cancer (BIFCOLC-QS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-15
End date: 2025-06-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) development and progression have been linked to the presence of pro-oncogenic bacterial strains in the intestine, such as Fusobacterium nucleatum, pks+ Escherichia coli and enterotoxigenic Bacteroides fragilis. These pathogenic bacteria produce toxins that can disrupt gut epithelial integrity resulting in heightened pro-inflammatory response, enhanced DNA mutations, and increased cell proliferation, which can eventually lead to adenoma formation. In addition, these bacterial pathogens show increased genotoxicity by forming invasive polymicrobial biofilms, thereby resulting in CRC development. Recently it has been reported that anatomical location plays a crucial role in CRC development, progression, microbial colonization, response to therapies and disease outcome. Indeed, right-sided CRC is generally associated with pro-oncogenic bacterial biofilms and is known to have an overall worse prognosis compared to left-sided CRC. Pathogenic bacteria use quorum sensing (QS) machinery in the gut for their communication, which is essential for biofilm formation. We aim to develop an intervention strategy employing QS machinery to engineer a probiotic bacterial strain with sensing and killing properties to detect and target these pro-oncogenic polymicrobial biofilms. The sensor device will detect autoinducers produced by pathogenic bacteria on encountering their biofilms, activating the killing device. The killing device expresses a biofilm degrading enzyme, Dispersin B, which will disrupt these biofilms and eventually kill the pathogenic bacteria residing in these biofilms by the type VI secretion system. These polymicrobial biofilms can act as a marker of CRC and help to understand the role of CRC-associated pathogenic bacteria in CRC development, which can eventually serve as a basis for developing future strategies for the diagnosis and treatment of CRC and other intestinal disorders associated with biofilms formed by pathogenic bacteria.

Keywords: colorectal cancer,gut microbiome,synthetic biology,quorum sensing and biofilms
Functional evolution of giant virus capsids (CAPSOLUTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2425000.0
EU funding (EUR): 2425000.0
Participants: 1
Project status: SIGNED

How do viruses identify their hosts in a challenging environment? This question is highly relevant for protist-infecting giant viruses in aquatic ecosystems, where the density of host cells is typically low and random encounters are rare. Giant viruses have genome sizes of up to two megabases and encode a vast genetic diversity, but we know almost nothing about their diverse capsid structures and the various strategies they use for infecting the next host cell. During the last decade, I have shed light on the symbiotic interactions between marine flagellates, giant viruses and their virophage parasites. With CAPSOLUTION, I will use our collection of freshwater flagellate cultures to characterize giant viruses with previously unknown capsid structures from oligotrophic lakes. We recently discovered two giant viruses with unprecedented capsid modifications: “Cometa virus”, whose capsid has a bundle of unique head fibers and a conical tail; and “Sentinel virus”, whose tentacle-like appendages span several micrometers. CAPSOLUTION will allow me to characterize the fascinating virion structures of Cometa and Sentinel viruses at molecular resolution and elucidate their function during host attachment and infection. What is the protein composition of these appendages and how are they assembled? How did they evolve? How common and diverse are modified capsids among giant viruses and how do they adapt to environmental constraints? I will address these questions in a multi-disciplinary approach combining the morpho-genomic characterization of natural giant virus communities with structure-function studies of newly isolated virus-host systems and evolutionary analyses of their appendage-associated genes. CAPSOLUTION will reveal how giant viruses use unique capsid modifications to adapt to their environment, thereby breaking new ground in microbiology and expanding our horizon of virus functioning in freshwater lakes.

Keywords: viruses of protists,viral ecology,virus isolation,electron microscopy,metagenomics,horizontal gene transfer,comparative genomics,experimental evolution,high mountain lakes
Exploiting Cellular Metabolism to Develop the Next Generation of mTOR Inhibitors (inhibiTOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2025-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The mTOR (mammalian/mechanistic Target of Rapamycin) kinase, as part of the mTORC1 and mTORC2 protein complexes, is the master controller of cellular and organismal physiology. Dysregulation of mTORC1 activity is tightly linked to human disease and ageing. Consequently, mTOR inhibitors have been tested in various clinical settings, however with little success and limited applicability so far, mainly due to low efficacy or adverse effects, thus highlighting the need for more potent and more specific compounds. For instance, the phosphorylation of most mTORC1 targets is resistant to rapamycin and its analogs (rapalogs). Furthermore, catalytic mTOR inhibitors demonstrate increased toxicity and cause unwanted metabolic effects mainly because they also block mTORC2 activity. We have recently identified malonyl-CoA, a metabolic intermediate of fatty acid biosynthesis, as a novel specific mTORC1 inhibitor in cells that shows improved characteristics over existing compounds as it blocks phosphorylation of all mTORC1 targets without affecting the activity of mTORC2 or other related kinases. Using our biochemical, structural and computational data as the basis for targeted compound development, we aim to develop synthetic malonyl-CoA derivatives as a new class of mTORC1 inhibitors with improved specificity and effectiveness. Because of the well-established role of mTORC1 in ageing and disease, these inhibitors are expected to be of profound scientific, clinical, and commercial interest.
Universality in the Kardar–Parisi–Zhang class (UnivKPZ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1402866.0
EU funding (EUR): 1402866.0
Participants: 1
Project status: SIGNED

This proposal aims to solve central open problems in the study of the Kardar–Parisi–Zhang (KPZ) class as well as develop new tools to study its models. The KPZ class consists of a large set of models, sharing common microscopic dynamical features and aiming at modeling the physical phenomena of random growth interfaces. The two main goals in my proposal are 1) Show that the KPZ-scaling is universal in a large family of non-integrable models in the KPZ class. It is believed that models in the KPZ class should converge, under what is called the KPZ-scaling, to a universal random object. Although widely believed, that the KPZ-scaling is universal is still largely conjectural and was shown mostly for a handful of exactly-solvable (integrable) models using deep connections to representation theory, combinatorics and random matrix theory. My plan is to show that, under the assumption of differentiability and curvature of the shape function, the KPZ-scaling exponents are universal in a large class of non-integrable models called Last Passage Percolation. The principal tools to address this problem will be probabilistic-geometric in nature, using objects such as geodesics and ideas from queuing theory. 2) Construct a new limiting object that will open new paths to study the KPZ equation. The KPZ equation is a central model in the KPZ class for a couple of reasons - firstly, it is believed to be the universal scaling limit in the intermediate disorder regime, and secondly, it is the crossover between two important physical phenomena - the Edwards-Wilkinson class and the KPZ class. I propose to introduce a new scaling limit that will shed light and enable us to study in new ways these two important aspects of the KPZ equation, as well provide new tools to address existing open problems. To achieve this, I plan to take the perspective of scaling limits of random walks in random environment (RWRE), and develop new and complementing tools within that theory.

Keywords: kpz universality class,kpz equation,last passage percolation,first passage percolation,scaling exponents,queue,tandem queuing networks
Restoration of wetland complexes as life supporting systems in the Danube Basin (Restore4Life)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Romania,Austria,Serbia,Germany,Hungary,Slovakia,Bulgaria,Ireland,Montenegro,Bosnia and Herzegovina,Spain,Slovenia,Greece,Croatia
Call: Danube river basin lighthouse – Protection and restoration of wetlands, flood plains, coastal wetlands and salt marshes and their biodiversity (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 8499953.75
EU funding (EUR): 8300641.25
Participants: 31
Project status: SIGNED

Restore4Life demonstrates the multiple socio-economic benefits generated by a holistic and transdisciplinary approach for the restoration of freshwater and coastal wetlands in the Danube basin that will contribute to new blue-green infrastructure supporting regional climate change resilience and mitigation. Restore4Life engages in 4 demonstration sites and 6 monitoring sites all across the Danube basin to make evident that increased delivery of key ecosystem services, as water and pollutant retention, carbon sequestration and tourism opportunities as well as improved resilience of water-dependent habitats will produce multiple socio-economic synergies that also provide opportunities for sustainable businesses and investments. Implementation of activities basically aiming to restore lateral connectivity in riverine corridors will be supported by a Restore4Life long term wetland restoration service/ Restore4Life Wetland Reconstruction Accelerator that combines timely integrative wetland management with a novel level of societal engagement. The Accelerator will provide tested indicators, monitoring approaches and decision support to identify adapted and future-oriented restoration goals, techniques and holistic road maps. Citizens and stakeholders will be empowered to engage in the co-design of projects by establishing stakeholder communities of practice, by twinning of similar projects at different realization stage, citizen science, thematic mobile apps and the use of multiple communication channels with special focus on visual, hands-on interactive information flow that promotes emotional links to water shaped environment. The various tools generated by Restore4Life also including handbooks for business audiences and targeted restoration roadmaps will secure the efficient replication of restoration activities in associated regions. In collaboration with similar mission activities, Restore4Life thus efficiently supports integrative social and economic transitions
Agriculture of Data (AgData) (AgData)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: COFUND actions
Partnership: Agriculture of Data (co-funded)
Countries involved: Belgium,Ireland,Portugal,Denmark,Italy,France,Poland,Spain,Finland,Netherlands,Bulgaria,Estonia,Germany,Slovenia,Greece,Latvia,Hungary,Türkiye,Canada,Israel,United Kingdom,Romania,Slovakia
Call: European Partnership of Agriculture of Data (HORIZON-CL6-2024-GOVERNANCE-02, 2024)
Start date: 2025-10-01
End date: 2032-09-30
Duration (months): 84.0
Total project cost (EUR): 99999998.75
EU funding (EUR): 29999999.38
Participants: 62
Project status: SIGNED

Agriculture of Data (AgData) AgData is a large endeavour with a variety of partners bringing together in particular research funders and research providers. Digital technologies and data are integral to the future of agriculture. AgData will enhance the use of data for developing data-based solutions, methodologies, and indicators to improve climate adaptation and resilience of agriculture as well as to minimise the undesired impact of agriculture on the climate, environmental quality, ecosystem services. AgData has focus on integrating data from different sources including EO, environmental, agricultural and other relevant data in the combination with data technologies (including AI). The partnership will build on results of existing (ongoing or finished) initiatives and projects. AgData will explore the potential for achieving synergies with programmes, projects and activities on digital and data technologies in member states and between EU and its member states and associated countries. At the EU level AgData will explore synergies with relevant topics / projects, partnerships, missions particularly in Cluster 6 and Cluster 4 of the Horizon Europe Programme as well as with the Digital Europe Programme, the EU Space Programme and the Common Agricultura Policy. Via its unique concept of Use Cases (UCs), the AgData partnership will deploy a broad variety of activities in all relevant branches of agriculture based on modern digital-technologies and data sources. The UCs will all be based on the Strategic Research and Innovation Agenda (SRIA). Besides the UCs AgData will also implement joint calls for transnational proposals resulting in financial support to third parties (FSTP).
Countering News Avoidance with Personalized News Formats (NAPNF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

This MSCA research project ‘Countering News Avoidance with Personalized News Formats (NAPNF)’ uses an interdisciplinary approach combining sociology and (media) psychology to ask: How does personalized content relate to news avoidance behaviors, and what steps can be taken to counteract their negative influence on news consumption? Despite news avoidance’s prominence in scholarly discussions on how to increase trust in media and other institutions, there is still a dissensus on how to both fundamentally conceptualize news avoidance and understand this audience behavior. NAPNF addresses this gap. To answer this question, this project will first determine the specific profiles of news avoiders via a qualitative approach which will lead to a more multifaceted comprehension of the different rationales of these avoiders. Second, I will conduct a panel survey on how these specific profiles relate to the level of knowledge of contested (e.g., migration) and uncontested issues (e.g., festivities). To date, research has insufficiently addressed to what extent news avoiders actually stay informed on societal issues. Third, personalized news formats based on these contested and uncontested issues will be used in experiments to evaluate whether these formats might stimulate or obstruct news avoidance. NAPNF combines the expertise at the University of Southern Denmark (SDU) and the Digital Democracy Centre (DDC) on media trust and literacy with my six years’ experience as a quantitative and qualitative scholar in journalism, AI, and newsroom innovation. The project will link academic research to practical recommendations which can contribute to the development of strategies that attract news avoiders in the European society, improve audience reach, and potentially generate societal benefits for the news industry.

Keywords: media literacy,media trust,news avoidance,news consumption,news overload
Advancing Data-Based Policy-Making in Urban and Regional Development and Wide-Scale Implementation for Sustainable Environments (UR-WISE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Economic Sciences
Countries involved: Serbia
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2491693.75
EU funding (EUR): 2491693.75
Participants: 1
Project status: SIGNED

UR-WISE aims to achieve long-term excellence, institutional recognition, visibility, and better integration of the host institution (FEUN) in the European Research Area. Led by ERA Chair holder, the project seeks to foster competitiveness in research funding by promoting institutional reforms at both system and organisational level. It aims to establish a permanent and excellent research group in the field of data-based policy analytics for resilient urban and regional development. This is to be achieved through clearly defined and measurable specific objectives: ● Establish an excellent research group fostering brain circulation and inter-sectoral mobility to create brain gain for FEUN, by increasing the number of R&I professionals relocated to ERA team and placing a strong emphasis on international, interdisciplinary and intersectoral mobility; ● Implement structural changes at FEUN to enhance its institutional framework by joining international networks and associations, forming alliances with economic faculties, and establishing partnerships with research-intensive institutions; ● Increase FEUN’s research excellence and profile in data-driven policy analytics through training opportunities, mentorship programs and collaboration with global partners; ● Enact organisational changes to enhance contributions to knowledge-based economy and secure competitive research funds by upgrading research infrastructure, founding research institute, and forming partnerships with technology park; ● Conduct a series of research to enhance FEUN's capacity for policy advising at local and national levels, by utilising a multifaceted methodology integrating spatial analysis, citizen engagement and multidimensional evaluation techniques. The project leverages the ERA Chair holder's international network to establish collaborations, foster research excellence and attract outstanding scientists, thereby addressing the need for more and better links between R&I actors across the ERA.

Keywords: data based policy making,urban and regional development,