Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On-demand Non-hermitian TOPology (ONTOP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

Physical materials can display a topological order, i.e. a collective organization characterized by a discrete number or “topological charge”. Because the integer nature of this charge must be preserved throughout the structure, topological order is intrinsically immune to perturbations and the system is said to be topologically protected. Recently, the replication of topological protection in optics has raised the interest of the scientific community for its potential ability to overcome fundamental problems—like the influence of imperfections intrinsically present in nanoscale-fabrication processes, which currently preclude the development of multiple photonic technologies. Yet, at optical frequencies the weak response of materials often precludes a topological approach such that even careful designs can only partially deliver the expected protection. In contrast to material properties, gain and loss can be easily manipulated in optics. While the exploitation of non-hermitian systems—with non-conserved energy—recently enabled the formation of topological order in wave physics, it simultaneously questioned our theoretical understanding of topology and offered a large variety of new degrees of freedom that are yet to be explored. Here I suggest exploiting the versatility of optical gain-loss to imprint topological order “on-demand” onto otherwise topologically trivial systems. Through non-uniform spatial distributions of optical gain and loss I intend to demonstrate theoretically the formation of topological protection in random systems and implement my predictions in existing experimental platforms. In sharp contrast with the conventional conception of topology that relies on careful and rigid designs, this project will explore the possibility to engineer topology through external control. In this way, I will trigger a paradigmatic change that will enable the development of new photonic devices, whose topology can be manipulated and reconfigured “on-demand”.

Keywords: non hermitian physics,topology,random media
Azabicycloalkanes: Synthesis and Applications (ABASynth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Small ring azabicyclic amines are predicted to possess unique molecular properties, but lack of synthetic access has to date prevented their thorough evaluation and deployment in high value functional molecules, including drugs. Much recent attention has focused on small-ring carbocyclic frameworks such as bicyclo[1.1.1]pentanes (BCPs), but analogous azabicyclic compounds are poorly described in the literature, which is surprising given the ubiquity of amines in bioactive organic molecules. A literature screen reveals that azabicyclo[2.2.1]heptanes are equivalent to BCPs in frequency of occurrence, but their [3.1.1] isomers and smaller azabicyclo[2.1.1]hexane relatives are much rarer. Azabicyclo[1.1.1]pentanes are essentially unknown, despite one isomer being an attractive bioisostere of the pyridine ring system. This proposal aims to address this ‘void’ in the bioisostere portfolio by introducing ‘small-ring azabicyloalkanes’ (ABAs) as novel motifs of great potential in drug discovery. As well as representing new bioisosteres for biologically-relevant heterocycles (not limited to pyridines, but also piperidines, pyrrolidines, etc.), ABAs offer new opportunities for drug design in their own right due to the impact of the bicyclic scaffold on amine hybridization. This project will deliver general access to small ring ABAs using a wide variety of novel chemical approaches, explore their functionalization, and demonstrate their application. It will use rational theoretical design to tailor ABA properties and develop structural models. Ultimately, this proposal will access a new domain of chemical space with broad application in organic and medicinal chemistry.

Keywords: small ring amines,bioisosteres,propellanes,drug design
Ecofriendly PROcessing System for the full exploitation of the OLIVE health potential in products of added value (EcoPROLIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Spain,Italy,Greece,Portugal
Call: Innovative solutions for sustainable novel food processing (H2020-SFS-2014-2, 2014)
Start date: 2015-09-01
End date: 2017-12-31
Duration (months): 28.0
Total project cost (EUR): 2417775.0
EU funding (EUR): 1999500.0
Participants: 9
Project status: CLOSED

The EcoPROLIVE project proposes an innovative processing for the full exploitation of high valuable constituents in the olive into novel products that are healthy and greener. The proposed process is very different from the current approaches of olive oil industrial production, and waste revalorization alternatives, as it follows a “zero waste” approach and all resulting products have commercial value. Part of the process is based on the patent WO2013030426 with further developments for quality and environmental improvements, such as the use of supercritical fluid extraction (SFE) with CO2 instead of n-hexane extraction, and including pulsed electric field (PEF) technology to improve the drying performance and the oil extraction yields. EcoPROLIVE project goals are: demonstration of the technical and economical feasibility of the processing and its environmental study; ensuring the market uptake of the technology and novel products, fully characterized (nutritional, functional, toxicological) to avoid market barriers; design of the optimal process, and scale-up from lab/pilot plant to preindustrial application (TRL6); validation at an operational environment (TRL7); monetizing the technology and developed process (patents) into scalable markets and replication in different scales and countries, starting with the main olive oil producers represented in the consortium (Spain, Italy, Greece, Portugal). Replication is expected in a total of 504 olive oil mills, that will deliver 37,000 tn olive oil, 3,700 tn functional oil (hydroxytyrosol, tyrosol, oleocanthal, oleuropein, others), and 44,400 tn phenol-rich fibre ingredient with intended use in bakery products (biscuit, bread). The global estimated profit is high (63 Mll€) as well as the environmental benefit associated to waste reduction (126,100 tn waste water). Conclusively EcoPROLIVE processing is presented as an economically and environmentally sustainable innovation that will promote the sector competitiveness.

Keywords: olive oil,phenols,fibre,supercritical fluid extraction,pulsed electric field,drying,sustainability,life cycle assessment,novel food,functional food
Ultra Legionella Inmunoanalysis System for Early Sensing (ULISENS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The general objective of ULISENS project will be focused on the commercial development and further commercialization of an automatic early warning system able to detect and quantify Legionella species in water. The system integrates an innovative fast detection automatic module able to carry out “in situ” analysis in real-time based on information and communication technologies to minimise the time for obtaining results. ULISENS will have the following functionalities: - Faster response time, with a time reduction of up to 99% compared with standard laboratory tests (1h vs 288h) - Greater reliability thanks to the certified detection and enumeration technology (accuracy of detection higher than 99%) - Lower cost, with reductions of up to 84% compared with standard laboratory tests (8€ per test vs 50€ per test) - Direct sampling from user’s network in real-time, no technical staff needed. - Sustainable detection biotechnology without maintenance - No hazardous waste generation (no biological waste) - Customizable online early warning module with internet connection to prevent users from risk. Apart from the previous technological objectives, ULISENS has also the following specific objectives: - To develop a business and exploitation plan, including the assessment of the cost‐effectiveness and exploitation potential of the solution. - To tackle main bottlenecks and barriers for the full commercialization of the innovative technologies, mainly related to legislative and regulatory aspects in each country. - To widely disseminate project outcomes to stakeholders and end‐users, strengthening synergies with other initiatives and platforms to reach the maximum impact. - To analyse market and business strategies in the sector in order to find the best combination of external agents and international entities to develop cooperation strategies for market exploitation and further products commercialization.

Keywords: legionella,early sensing,biotechnology,water,cooling towers,business plan,commercialization,exploitation,health
Real proven solutions to enable active demand and distributed generation flexible integration, through a fully controllable LOW Voltage and medium voltage distribution grid (UPGRID)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Spain,Spain,Poland,Norway,Sweden,Poland,France,United Kingdom,United Kingdom,Portugal,Portugal,Portugal
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 15614856.28
EU funding (EUR): 11937258.0
Participants: 34
Project status: CLOSED

Unlike the control and observability put in service in HV/MV, LV networks are still being substantially managed as usual: no visibility of power and voltage or grid components status, poor knowledge of connectivity, manual operation of switches or few tools for worker support. The LV grid characteristics (radial topology, exposition to local disturbances, local accumulation of distributed generation, technical and no-technical loses, aging heterogeneous, etc.) limit the construction and refurbish of LV electric infrastructure and the integration on it of grid remote monitoring and operation and automation resources, bringing to difficulties in the implementation of the LV Smart Grid and the integration of Distributed Generation Resources and Active Demand Management (ADM). Smart metering deployment Mandates offer an opportunity to maximize the gains derived from the obliged functions to be deployed related to smart metering, developing and integrating additional innovative grid and ICT infrastructure, functions, services and tools improving grid operation performance and quality and paving the way for benefits and business opportunities for the involved actors (DSOs, customers, retailers and ESCOs). The project aims to develop, deploy and demonstrate innovative solutions (grid systems, functions, services and tools) for advanced Operation and Exploitation of LV/MV networks in a fully smart grid environment improving the capacity of that networks as enablers for Distributed Generation, ADM, Customer empowering and business opportunities. The project proposes 4 real pilots in Portugal, Poland, Spain and Sweden covering: Smart grid monitoring and operation, advanced grid maintenance, DER and ADM integration and active Consumer awareness and participation with cost efficiency. Also proposes specific WPs to maximize the socioeconomic impact of results, especially for their market uptake, business opportunities triggering and society awareness on the smart grid benefits

Keywords: lv networks,smart grid,distributed generation resources,active demand management,retailers and escos
SMALL WIND ENERGY, A HIGHLY EXPLOITABLE RESOURCE (Venturas)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Wind Power brings the lowest cost of electricity generation of the renewable energy technologies available today. This fact has positioned the wind energy as the most promising renewable energy technologies to power our future: up to 12% of global electricity by 2020 will be supplied by wind reducing CO2 emissions by more than 1.5 billion tons per year, more than 5 times actual level. Although the cost of electricity from onshore wind power is already at very low level, wind energy poses new challenges such as a limited number of available sites with suitable wind speed, location, and access, limited predictability and short-/long-term variability. And this is why; investments in specialised low wind turbines and in the utilisation of smart grid systems vs. current power generation facilities are key to efficiently and reliably improve the utilisation of wind systems. Moreover, the small wind turbine sector continues to develop growing at a Compound Annual Growth Rate (CAGR) of 16.4% (global cumulative installed capacity of 4.8GW by 2025). In this scenario, Alfapress and Sidac find their major business opportunity with VENTURAS focused on small consumers. VENTURAS is a small (gearless) wind turbine that comprises 3 rotor blades that can change its aerodynamic surface over time (variable twist and active pitch control). Hence, the power production of the turbine is maximized and at the same time the operating loads are reduced. It is suitable for low/very low wind speed locations having an exclusive capacity factor (Cp) and, thus, the merest cost of energy. With the market launch of VENTURAS wind turbine, Alfapress and Sidac plan to gain market share within the EU small wind industry for microgeneration capacities (from 5kW to 60kW): 1) initially in 2020 in our home market, Italy and UK, 2) to expand sales to Germany, Denmark, and Spain in 2021, 3) Then to other countries. In doing so, our consortium will create over 82 jobs and generate 36.82M€ market opportunity.

Keywords: small wind energy,microgeneration,offgrid,onshore,low wind,very low wind,iec classes,ongrid,variable pitch,active pitch control,maximum aerodynamic efficiency,capacity factor
In vivo functional screening via CRISPR-Cas9 to systematically identify cardiomyocyte receptors as targets for the innovative therapies for myocardial infarction and heart failure (R-FunSel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Myocardial Infarction (MI) is the leading cause of heart failure, which represents a major medical, social and economic burden worldwide. There is a desperate need for new therapies for these conditions. Here we propose a new approach for the in vivo, unbiased and systematic identification of receptors involved in MI, which might become targets for innovative therapeutics. The method we developed, named Reverse Functional Selection (R-FunSel) takes advantage of the CRISPR/Cas9 genome editing technology and is based on the intracardiac screening of a library of single-guide (sg) RNAs in Cas9 transgenic mice upon gene delivery using the highly cardiotropic adeno-associated virus serotype 9 (AAV9). First, we will construct an arrayed library of sgRNAs, individually cloned into AAV9 vectors, driving CRISPR/Cas9 towards each of the receptor genes expressed by cardiomyocytes. Second, we will package pools of this library and transduce the mouse heart, at a multiplicity by which each vector enters a different cell. Then, MI will be applied as a selective stimulus and, after a few weeks, vector inserts will be recovered from the viable tissue and their frequency measured by Next Generation Sequencing. R-FunSel is based on Darwinian selection of cardiomyocyte survival, thus sgRNAs that will be lost are likely to target cardioprotective genes while those that are enriched code for detrimental factors. The choice to develop R-FunSel for the systematic screening of cardiomyocyte receptors will allow identification of novel druggable targets for the development of therapeutics, either in the form of molecules activating the protective receptors or inhibiting them or their ligands. R-FunSel is based on solid technologies that support the feasibility and power of the in vivo screening approach. Compared to biochemical or phenotypic studies, screening in vivo directly for function is a novel strategy to move basic research into translational medicine at a quick pace.

Keywords: crispr,cas9 adeno associated viral vectors aav screening functional selection heart failure
Lane-free Artificial-Fluid Environment for Vehicular Traffic (TrafficFluid)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Greece
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-12-01
End date: 2025-05-31
Duration (months): 66.0
Total project cost (EUR): 2495500.0
EU funding (EUR): 2495500.0
Participants: 1
Project status: SIGNED

Traffic congestion is a serious threat for the economic and social life of modern societies as well as for the environment, which calls for drastic and radical solutions. The proposal puts forward an utterly original idea that leads to a novel paradigm for vehicular traffic in the era of connected and automated vehicles (CAVs) and is based on two combined principles. The first principle is lane-free traffic, which renders the driving task for CAVs smoother and safer, as risky lane-changing manoeuvres become obsolete; increases the static and dynamic capacity of the roadway due to increased road occupancy; and mitigates congestion-triggering manoeuvres. The second principle is the nudge effect, whereby vehicles may be "pushing" (from a distance, using sensors or communication) other vehicles in front of them; this allows for traffic flow to be freed from the anisotropy restriction, which stems from the fact that human driving is influenced only by downstream vehicles. The nudge effect may be implemented in various possible ways, so as to maximize the traffic flow efficiency, subject to safety and convenience constraints. TrafficFluid combines lane-free traffic with vehicle nudging to provide, for the first time since the automobile invention, the possibility to design (rather than merely describe or model) the traffic flow characteristics in an optimal way, i.e. to engineer the future CAV traffic flow as an efficient artificial fluid. To this end, the project will develop and deliver the necessary vehicle movement strategies for various motorway and urban road infrastructures, along with microscopic and macroscopic simulators and traffic management actions. TrafficFluid risk stems from the immense challenge of designing a new traffic system from scratch; however, we expect that the project will trigger a whole new path of international innovative research developments and testbeds that would pave the way towards a new efficient traffic system in the era of CAVs.

Keywords: connected and automated vehicles,new traffic paradigm
Modeling the past climates of planet Mars to understand its geology, its habitability and its evolution (Mars through time)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2025-11-30
Duration (months): 74.0
Total project cost (EUR): 2493836.0
EU funding (EUR): 2493836.0
Participants: 2
Project status: SIGNED

Over the past decades, the robotic exploration of the planet Mars has produced a wealth of geological observations. They show that Mars has not always been the desert planet of today. It has seen eras conducive to rivers and lakes, ice ages, and even periods with a collapsed atmosphere. These different epochs are the reason why Mars remains the objective of space agencies, as they evoke the possibility of past habitability and spectacular climate changes. Yet, in spite of all the data, the climatic processes that have shaped Mars’ surface through time remain largely unknown. What happened on Mars? Was the Red Planet suitable for life? What explains its evolution? The objective of this project is to develop numerical models to simulate the past environments of Mars.A completely new “Mars Evolution Model” will be created by asynchronously coupling hydrology, glacial flows and ground ice models with a new generation 3D Global Climate Model (GCM). This GCM will be derived from the one that we have previously designed to simulate present day Mars. We will radically update it using new technologies to represent the details of the surface as well as all the processes that affected Mars when its environment evolved because of the oscillations of its orbit and obliquity, during changes in the atmospheric composition, or through events like meteoritic impacts or volcanic eruptions. Notably, we will highlight the last ten millions years that have been recorded in the polar layered deposits, whose formation will be simulated for the first time realistically. These new tools will address numerous enigmas found in Mars sciences. They will also offer a new platform to study specific processes such as the atmospheric escape through time or the chemical alteration of the soil. Furthermore, the project will test our capacity to model planetary environments and climate changes, as well as provide lessons on the evolution of terrestrial planets and the possibility of life elsewhere.

Keywords: climate modelling paleoclimates planet mars