Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elites, networks, and power in modern urban China (1830-1949). (ENPMUC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-05-31
Duration (months): 69.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

This project proposes a step-change in the study of modern China reliant upon scalable data-rich history. It will deliver precise historical information at an unprecedented scale from heretofore untapped sources - as well as reshaping the analysis of existing sources - to create a new dimension in the study of the transformation of elites in modern China. It will deploy an array of cutting-edge digital methods — including data mining, sampling, and analysis within an integrated virtual research environment. To establish the validity of this approach, the project focuses on the three urban areas (Shanghai, Beijing/Tianjin, Canton/Hong Kong) that had the most profound impact on the course of modern Chinese history. Starting from the mid-19th century, the narrow elite of Confucian-trained scholar-officials that had ruled the country for a millenium was finally swept away. Power and social prestige shifted to socially more diversified groups of Chinese and foreigners who operated within interlocked transnational networks. The project will challenge the China-centered and group-based approach dominant in the historical literature of the past two decades. The project envisions elites in urban China as actors whose status, position, and practices were shaped by the power configurations that developed over time and whose actions through institutions and informal/formal networks in turn were a determining factor in redrawing social and political boundaries. The project will place the emphasis on the networks through which information, capital, and individuals circulated. It will investigate the transnationalization of elites as a process that overstepped the limits of institutions and nation states. The key issue that the project will address is breaking through existing limits of access to historical information that is embedded in complex sources and its transformation into refined, re-usable and sustainable data for contemporary and future study of modern China.

Keywords: china,urban history,elites,networks,cities,spatial analysis,digital methods,data mining,text analysis
Biocatalysis for Sustainable Chemistry – Understanding Oxidation/Reduction of Small Molecules by Redox Metalloenzymes via a Suite of Steady State and Transient Infrared Electrochemical Methods (BiocatSusChem)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 1997286.0
EU funding (EUR): 1997286.0
Participants: 1
Project status: SIGNED

Many significant global challenges in catalysis for energy and sustainable chemistry have already been solved in nature. Metalloenzymes within microorganisms catalyse the transformation of carbon dioxide into simple carbon building blocks or fuels, the reduction of dinitrogen to ammonia under ambient conditions and the production and utilisation of dihydrogen. Catalytic sites for these reactions are necessarily based on metals that are abundant in the environment, including iron, nickel and molybdenum. However, attempts to generate biomimetic catalysts have largely failed to reproduce the high activity, stability and selectivity of enzymes. Proton and electron transfer and substrate binding are all finely choreographed, and we do not yet understand how this is achieved. This project develops a suite of new experimental infrared (IR) spectroscopy tools to probe and understand mechanisms of redox metalloenzymes in situ during electrochemically-controlled steady state turnover, and during electron-transfer-triggered transient studies. The ability of IR spectroscopy to report on the nature and strength of chemical bonds makes it ideally suited to follow the activation and transformation of small molecule reactants at metalloenzyme catalytic sites, binding of inhibitors, and protonation of specific sites. By extending to the far-IR, or introducing mid-IR-active probe amino acids, redox and structural changes in biological electron relay chains also become accessible. Taking as models the enzymes nitrogenase, hydrogenase, carbon monoxide dehydrogenase and formate dehydrogenase, the project sets out to establish a unified understanding of central concepts in small molecule activation in biology. It will reveal precise ways in which chemical events are coordinated inside complex multicentre metalloenzymes, propelling a new generation of bio-inspired catalysts and uncovering new chemistry of enzymes.

Keywords: infrared spectroscopy,metalloenzymes,bioelectrochemistry,proton coupled electron transfer
Elucidating the molecular and biophysical mechanism of coral calcification in view of the future acidified ocean (Ca2Coral)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1499741.0
EU funding (EUR): 1499741.0
Participants: 1
Project status: SIGNED

Although various aspects of biomineralisation in corals have been studied for decades, the basic mechanism of precipitation of the aragonite skeleton remains enigmatic. Two parallel lines of inquiry have emerged: geochemist models of calcification that are directly related to seawater carbonate chemistry at thermodynamic equilibrium. Here, the role of the organisms in the precipitation reaction is largely ignored. The second line is based on biological considerations of the biomineralisation process, which focuses on models of biophysical processes far from thermodynamic equilibrium that concentrate calcium ions, anions and proteins responsible for nucleation in specific compartments. Recently, I identified and cloned a group of highly acidic proteins derived the common stony coral, Stylophora pistillata. All of the cloned proteins precipitate aragonite in seawater at pH 8.2 and 7.6 in-vitro. However, it is not at all clear if the expression of these proteins in-vivo is sufficient for the formation of an aragonite skeleton at seawater pH values below ~7.8. Here using a combination of molecular, biophysical, genomic, and cell biological approaches, we proposed to test the core hypothesis that, unless wounded or otherwise having skeletal material exposed directly to seawater, stony zooxanthellate corals will continue to calcify at pH values projected for the CO2 emissions scenarios for 2100. Specifically, the objectives of Ca2Coral are to: 1) Use functional genomics to identify the key genes and proteins involved both in the organic matrix and skeleton formation in the adult holobiont and during its larval development. 2) Use a genetics approach to elucidate the roles of specific proteins in the biomineralisation process. 3) Use ultra-high resolution imaging and spectroscopic analysis at different pH levels to elucidate the biomineralisation pathways and mineral precursor in corals in the adult holobiont and during its larval development.

Keywords: acidic proteins,biomineralisation,corals,amorphous calcium carbonate,mineral formation,coral development,biomineralisation pathways,cryo sem
Intrapopulation communication and collective cell decisions of hematopoietic stem cells (IC-CCD-qHSC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2312500.0
EU funding (EUR): 2312500.0
Participants: 1
Project status: SIGNED

Hematopoietic stem cells (HSCs) contribute to blood cell production throughout life and are found at rare, yet tightly regulated frequencies in adult bone marrow (BM). During embryonic and postnatal development, HSCs expand through continuous self-renewing proliferation. Upon entry into adulthood the vast majority of HSCs synchronously convert to a quiescent state. From then on, at any given moment very few HSCs are found in active stages of cell cycle, which suffices to compensate basal HSC loss due to differentiation or cell death. Since proliferation rates of individual HSCs are heterogeneous, entry and exit from cell cycle need to be coordinated at the level of the HSC pool. To date, the mechanisms that orchestrate this collective proliferative behavior and effectively control the maintenance of homeostatic HSC numbers remain unknown. In preliminary work for this project we have customized a pipeline that combines 3D microscopy, deep learning-based image analysis and spatial statistics. Using these tools, we observed that despite showing broad spatial heterogeneity, HSCs tend to cluster and accumulate in relatively large regions of the BM. We now postulate that molecular crosstalk between proximal HSCs enables them to perceive their local densities and triggers collective regulation of HSC function to preserve homeostasis. Through a multidisciplinary approach involving high-level microscopy, spatial analyses, comprehensive metabolomic profiling and single-cell transcriptomics we aim to 1) characterize the basic anatomical and functional features of spatial dependencies between HSCs 2) study the potential role of quorum-sensing mechanisms in HSC crosstalk and 3) investigate if competition for molecular resources in local neighborhoods contributes to maintenance of HSC homeostasis. Our research has the potential to unravel novel complex forms of cellular interplay and substantially advance our understanding of hematopoietic tissue organization.

Keywords: 3d imaging,deep learning,spatial statistics,hematopoietic stem cells,quorum sensing,cellular competition
Strategic Uncertainty in Economic Environments (SUEE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1480325.0
EU funding (EUR): 1480325.0
Participants: 1
Project status: SIGNED

This proposal concerns two sets of projects that tackle theoretical challenges raised by the data broker and online advertisement industry. 1-Strategic Uncertainty (SU) in Economic Environments: By assuming that individuals have correct beliefs about others' behavior, the equilibrium approach in economics assumes away SU. But SU is central to many settings. Testament to this is the existence of a data broker industry, in which data on agents' behavior are traded: this information would have no value without SU. Within game theory, non-equilibrium concepts such as rationalizability and models of level-k reasoning have been developed to study SU. But these models have had a limited impact on broader economics. This is partly due to the weakness and limited tractability of these concepts. Part 1 tackles SU in order to favor a better integration within economics. From a behavioral perspective, I propose axiomatic foundations that justify modeling individuals' reasoning as stemming from a cost-benefit analysis, and investigate (theoretically and experimentally) how these ideas shed light on the occurrence of equilibrium coordination under SU, i.e. as the result of purely subjective reasoning. From a classical perspective, I develop uniqueness and monotone comparative statics results for non-equilibrium concepts, to favor a better integration of SU in standard economics. Applications include problems of information disclosure of strategic datasets and identification in models of social interactions. 2-Online Auctions with Digital Marketing Agencies (DMA): I study the role of DMA in the auctions used to sell advertisement space on the web. I analyze how collusive bidding can emerge from bid delegation to a common DMA and how this undermines both revenues and efficiency of the auctions used by key players in the industry such as Facebook, Google and Microsoft-Yahoo!. Implications and extensions include business, policy and economics methodology.

Keywords: strategic uncertainty,strategic thinking,level k,rationalizability,bounded rationality
Demonstrating a highly-efficient and cost-effective energy conversion technology for waste heat recovery (Heat2Energy)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project presents a new energy conversion technology for low-grade waste heat recovery. It transforms thermal energy (80°C - 400°C) from different heat sources on demand either in mechanical, electrical energy or higher/lower temperature levels. The working principle is: Due to a waste heat supply a working medium expands against a working fluid and against the Energy Converting Unit that works as a hydraulic engine to generate different kind of energy forms. Heat2Energy achieves much higher overall efficiencies of >20% than conventional technologies like ORC. The users can be found world-wide, where ever thermal processes happen. They are either application-specific end users (private, public organisations, individuals), components manufacturers for integration in their own products/processes or system manufacturers. Depending on the heat source advent, the potential markets are: Industry (waste heat recovery; efficiency increase of existing power plants), Home (energy efficiency increase of buildings), Renewables (solar thermal, biomass, geothermal) and Mobility (energy-efficient drives for ships, locomotives and trucks). The commercial potential to recover the industrial waste heat in Europe is estimated at 2,000 PJ/a. In Germany, the market value of waste heat recovery exceeds €25 Billion/a. It is a growing high volume market as applications are so manifold across many sectors. The economic benefits are substantial energy cost savings, reduction of GHG emissions and the possibility of operating energy-autonomous applications. The technology significantly contributes to the sustainable use of natural resources and to secure and decarbonise the European energy system including the integration of renewables. The feasibility assessment shall prepare the demonstration of the technology in the cement industry to provide mechanical drive for the screw-type compressor to generate compressed air, to elaborate the business plan and to finally promote the technology.

Keywords: waste heat recovery,energy converting unit,heat conversion,combined heat,cold and power,advanced orc,heat storage,pressured air generation
Invariants of local Calabi-Yau 3-folds (INVLOCCY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The study of Gromov-Witten (GW), Donaldson-Thomas, and stable pair invariants of Calabi-Yau 3-folds X forms an active area of research for geometers and physicists. These invariants play a central role in string theory and have relations with many branches of mathematics including number theory and representation theory. I am interested in questions of enumerative geometry on algebraic surfaces S. Invariants of the total space X of the canonical bundle over S can be used to answer classical enumerative questions on S. Two recent developments in stable pair theory are: (1) A better understanding of stable pairs on X not contained in the zero-section S. (2) Refinements of stable pair invariants. The first theme of my project is the study of stable pairs on X not contained in S in relation to enumerative questions. For Fano surfaces, GW invariants with sufficiently many point insertions are enumerative. By the GW/stable pairs correspondence these are equal to certain stable pair invariants of X. When the curve class is not sufficiently ample, the stable pair count may include stable pairs on X not contained in S. I propose to compute such contributions in order to obtain curve counts on S outside the ample regime. The second theme of my project is the study of refined stable pair invariants. I intend to relate the refined topological vertex appearing in the physics literature to refined invariants in the mathematics literature. Since stable pair invariants are often easiest to calculate of all the invariants of Calabi-Yau 3-folds, I expect this leads to new curve counting formulae and new calculations of refined invariants. Utrecht University, housing one of the leading schools in geometry in Europe, and Prof. Faber, one of the world's leading experts on moduli of curves, provide the perfect location and supervisor for this project. The diverse expertise of the members of the Mathematics (and Physics) Department at UU allow me to explore links with other areas.

Keywords: gromov witten and stable pair invariants,local calabi yau 3 folds,classical curve counting,refined invariants,topological vertex
Europe’s Lost Frontiers: exploring climate change, settlement and colonisation of the submerged landscapes of the North Sea basin using ancient DNA, seismic mapping and complex systems modelling (Lost Frontiers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: China,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2021-11-30
Duration (months): 72.0
Total project cost (EUR): 2497843.0
EU funding (EUR): 1834094.25
Participants: 7
Project status: CLOSED

The only lands on Earth that have not been explored in any depth by science are those that have been lost to the oceans. Global warming at the end of the last Ice Age led to the inundation of vast landscapes that had once been home to thousands of people. These lost lands hold a unique and largely unexplored record of settlement and colonisation linked to climate change over millennia. Amongst the most significant is Doggerland. Occupying much of the North Sea basin between continental Europe and Britain it would have been a heartland of human occupation and central to the process of re-settlement and colonisation of north Western Europe during the Mesolithic and the Neolithic. Within this submerged landscape lies fragmentary yet valuable evidence for the lifestyles of its inhabitants including the changes resulting from both the encroaching sea and the introduction of Neolithic technologies. This inundated landscape cannot be explored conventionally, however pioneering work by the applicant’s research group has led to the rediscovery of Doggerland through the creation of the first detailed topographic maps relating to human occupation in the Early Holocene. Within this project world-leading innovators in the fields of archaeo-geophysics, molecular biology and computer simulation will develop a ground-breaking new paradigm for the study of past environments, ecological change and the transition between hunter gathering societies and farming in north west Europe. It will: 1) use the latest seismic reflectance data available to generate topographical maps of the whole of early Holocene Doggerland that are as accurate and complete as possible. 2) reconstruct and simulate the palaeo-environments of Doggerland using ancient DNA extracted directly from sediment cores. 3) explore the Mesolithic landscapes and also identify incipient Neolithic signals indicating early contact and development within the region of Doggerland.

Keywords: marine archaeology,palaeolandscapes,coastal shelf prehistoric research