Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Analysis of Geometrical Effects on Dispersive Equations (ANADEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France,France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1293763.0
EU funding (EUR): 1293763.0
Participants: 3
Project status: SIGNED

We are concerned with localization properties of solutions to hyperbolic PDEs, especially problems with a geometric component: how do boundaries and heterogeneous media influence spreading and concentration of solutions. While our first focus is on wave and Schrödinger equations on manifolds with boundary, strong connections exist with phase space localization for (clusters of) eigenfunctions, which are of independent interest. Motivations come from nonlinear dispersive models (in physically relevant settings), properties of eigenfunctions in quantum chaos (related to both physics of optic fiber design as well as number theoretic questions), or harmonic analysis on manifolds. Waves propagation in real life physics occur in media which are neither homogeneous or spatially infinity. The birth of radar/sonar technologies (and the raise of computed tomography) greatly motivated numerous developments in microlocal analysis and the linear theory. Only recently toy nonlinear models have been studied on a curved background, sometimes compact or rough. Understanding how to extend such tools, dealing with wave dispersion or focusing, will allow us to significantly progress in our mathematical understanding of physically relevant models. There, boundaries appear naturally and most earlier developments related to propagation of singularities in this context have limited scope with respect to crucial dispersive effects. Despite great progress over the last decade, driven by the study of quasilinear equations, our knowledge is still very limited. Going beyond this recent activity requires new tools whose development is at the heart of this proposal, including good approximate solutions (parametrices) going over arbitrarily large numbers of caustics, sharp pointwise bounds on Green functions, development of efficient wave packets methods, quantitative refinements of propagation of singularities (with direct applications in control theory), only to name a few important ones.

Keywords: microlocal analysis,hyperbolic pde,boundary value problems,analysis on manifolds,wave and schrodinger equations,dispersion,strichartz,eigenfunctions,propagation of singularities
Microscopy - Making optimal use of photons and electrons (MicroMOUPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1672752.0
EU funding (EUR): 1672752.0
Participants: 1
Project status: SIGNED

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

Keywords: high sensitivity,low damage microscopy,sub shot noise measurements,electron optics,electron light interaction
Accelerating Clinical Translation. Charting the Politics of Translation in the European Union (ACTrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-12
End date: 2020-03-13
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

In the post–genomic era, innovation policies in biomedicine are increasingly being driven by the notion that constant advancements in biological knowledge fail to materialize into tangible therapeutic outcomes. Discursively framed in terms of a “gap” between “bench” and “bedside” in need of urgent “bridging”, this representation of the shortcomings of biomedical innovation has propelled growing efforts tailored towards the clinical translation of research results. In the European Union, the acceleration of clinical translation has been positioned as a cornerstone of its innovation strategy, as attested by the launch of a host of translational policy initiatives and a vast array of regulatory reforms in the process of medicines approval. However, in spite of its growing relevance, the broader expectations, dynamics and implications of the translational enterprise at EU level have yet to be comprehensively drawn out by the social sciences. This project sets out to accomplish this objective. Drawing from qualitative research methodologies, it investigates the articulation of translational initiatives in the policy and regulatory context of the EU, with the aim to chart and analyze the different epistemic and normative expectations underpinning translational policies, the sociotechnical dynamics of their implementation, as well as their social and political implications. Specifically, the project focuses on the mobilization of translational initiatives into the service of EU socio–political consolidation and its transboundary exercise of political, economic and cultural power, and will investigate the possible tensions and trade–offs between the political ideal of competitiveness enshrined in such initiatives, and those of democratic accountability and social justice.

Keywords: clinical translation,biomedical innovation,european union
Pan-Arctic observing System of Systems: Implementing Observations for societal Needs (Arctic PASSION)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Italy,India,Germany,Italy,Germany,Finland,Sweden,Norway,Norway,Finland,Russian Federation,Finland,Switzerland,Norway,Norway,Belgium,Korea, Republic of,Norway,France,Netherlands,United States,Denmark,United Kingdom,Denmark,Greenland,United Kingdom,Canada,Japan
Call: Supporting the implementation of GEOSS in the Arctic in collaboration with Copernicus (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 15688978.75
EU funding (EUR): 14998301.25
Participants: 37
Project status: SIGNED

Arctic PASSION will address the urgent need for coordinated and accessible Earth observation and information services for the Arctic region. Despite significant international effort in the past, elements of the current pan-Arctic observing network still remain fragmented, disconnected, or have other critical shortcomings. Our aim is to overcome these shortcomings and to advance towards a fully integrated pan-Arctic Observing System of Systems (pan-AOSS). Working under the SAON framework and in partnership with rights-and stakeholders, Arctic PASSION will strengthen international scientific observations, community-based monitoring, and Indigenous knowledge and local knowledge within an observing system. We will co-create an innovative pan-AOSS that truly represents the diverse range of needs of the different user-groups and decision makers. The resultant pan-AOSS will provide its users with unrestricted access to the latest-available Arctic observations, including better access to Copernicus Arctic products. It will empower Arctic communities, policy makers and industries to make knowledge-based decisions. These will benefit society and support the adaptation and sustainability of the objectives of the UNFCCC, the IPCC and associated protocols. Arctic PASSION will also fill critical gaps in observations and improve the archiving, handling and interoperability of Arctic data systems. It will use these improvements to develop and implement eight new EuroGEO Pilot Services that will support emergency preparedness, food security, and responses to climate and socio-economic changes in the Arctic. The combination of the work performed by Arctic PASSION will provide compelling evidence to GEO to update Arctic GEOSS’ Community activity’ to the higher level of GEO ‘Regional Initiative’. Our legacy will be a stronger European voice in Arctic observing, and a more inclusive pan-Arctic observing system that supports a prosperous, sustainable and environmentally secure Arctic.

Keywords: indigenous peoples,indigenous knowledge,co development,saon,sustainable development,adaptation,interoperability,earth observations
RapidAI4EO - Advancing the State-of-the-Art for Rapid and Continuous Land Monitoring (RapidAI4EO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Austria,Germany,Belgium
Call: Copernicus evolution: Research activities in support of the evolution of the Copernicus services (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2023-03-31
Duration (months): 27.0
Total project cost (EUR): 1498987.5
EU funding (EUR): 1498987.5
Participants: 5
Project status: SIGNED

New catalogues of nearly daily temporal data will soon dominate the global archives. However, there has been little exploration of Deep Learning (DL) techniques to leverage the spatiotemporal dimension at scale. Training data remains rare relative to the spatiotemporal sampling which is necessary to adequately capture natural and man-made phenomenology latent in these large volumes of high cadence data. The project will establish the foundations for the next generation of rapid cadence land monitoring applications by: 1. Creating the most complete and dense spatiotemporal training set, combining Sentinel-2 with high cadence, very high resolution, harmonized multispectral Planet imagery at 500,000 patch locations over Europe, and open sourcing these datasets for the benefit of the entire remote sensing community. 2. Developing and benchmarking alternative ways of detecting and classifying change from very high cadence observations by training state-of-the-earth multiscale supervised and unsupervised DL classifiers on these unique data sources. 3. Delivering high cadence high resolution change detection heatmaps for the entire European continent. 4. Demonstrating a highly effective end-to-end process to monitor and update the CORINE land cover product, with emphasis on improved understanding of land use, speeding up update cycles and reducing maintenance costs. Our framework constitutes a game changer in the ability to derive time-critical and location-specific insights into dynamic land surface processes. Our ambition is to enable new and better ways of measuring and understanding the human footprint on our planet, which is a key challenge of the UN Sustainable Development Goals. This project brings together industry leaders with a strong, demonstrated record of disruptive innovations and young innovators: Planet Labs, Vision Impulse, VITO, IIASA and ONDA DIAS/Serco Italia.

Keywords: high spatiotemporal cadence,deep learning,multi source,multi scale,harmonization,daily revisits,corine,sdgs,change detection,land use,land cover,sentinel 2,planetscope,planet
Energy harvesting via wetting/drying cycles with nanoporous electrodes (EHAWEDRY)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ukraine,Spain,Italy,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 2997615.0
EU funding (EUR): 2997615.0
Participants: 8
Project status: SIGNED

Huge amounts of energy are wasted as low grade heat during conversion, transportation and end use. While several technologies can convert heat into electricity, none of them is cost-effective for the conversion of low-grade waste heat. EHAWEDRY proposes a radically new concept for converting low grade waste heat into electricity. EHAWEDRY will couple charging/discharging cycles of electrochemical super-capacitors with the drying/wetting of their nanoporous electrodes, exploiting the proportionality of the capacitor capacity to its electrode/electrolyte contact area. Previous attempts to couple charging/discharging cycles with changes in the electrode/electrolyte contact area aimed at harvesting the mechanical energy used to drive the change in the contact area. The power generated by these mechanical energy harvesters is relatively low, mainly because they have to use smooth capacitor plates (electrodes) to avoid generating too large capillary forces counteracting the harvested displacement. EHAWEDRY proposes a paradigm shift from the energy harvesting strategies previously used. Instead of mechanically changing the electrode/electrolyte contact area by displacing smooth electrodes, EHAWEDRY will change the electrode/electrolyte contact area by modifying the electrolyte level within nanoporous electrodes through drying/wetting cycles. The use of nanoporous electrodes will increase by many orders of magnitude the electrode/electrolyte contact area, which will translate into several orders of magnitude larger amounts of harvestable energy per cycle. Via pioneering fundamental research, EHAWEDRY targets the generation of a harvester prototype that reaches a volumetric power densities of the order of 10 kW/m3, comparable to established waste heat recovery technologies such as Rankine cycle engines, but with advantages in terms of cost, design flexibility, scalability and potential for the cost-effective harvesting of low grade waste heat without upgrading.

Keywords: wetting,drying,energy conversion,waste heat recovery,super capacitor,nanoporous,electrode,electrical capacity,low grade waste heat,evaporation,water,modelling,heat and mass transfer
Reprogramming cell identity to develop new therapies against Cholangiopathies (Relieve-Chol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 149907.0
EU funding (EUR): 149907.0
Participants: 1
Project status: CLOSED

Intra- hepatic Cholangiocytes represent one of the main cell type of the liver with hepatocytes. They line the biliary tract and fulfill essential functions such as bile modification and transport. Cholangiocytes are targeted by a diversity of diseases including genetic disorders such as Cystic Fibrosis. There is currently no cure for disorders affecting cholangiocytes and end stage disease require liver transplantation. Importantly, primary cholangiocytes obtained from biopsy can not be grown in vitro without loosing their functional characteristics while transformed cells and animal models rarely recapitulate the entire pathophysiology of human diseases. Consequently, the development of novel drug and therapies remains problematic despite an urgent clinical need. Human induced pluripotent stem cells could provide an advantageous solution to bypass this major challenge. Indeed, these pluripotent stem cells are generated by direct reprograming of somatic cells and they can proliferate almost indefinitely in vitro while maintaining their capacity to differentiate into almost any cell types. Interestingly, hIPSC can be derived from patients with genetic disorders and then differentiated into the relevant cell types for disease modeling purposes. Of direct interest, we recently developed a protocol to generate cholangiocytes from hIPSCs using chemically define conditions. The resulting cells display functional characteristics of their in vivo counterpart including the capacity to transport bile acid. Here, we propose to enable our culture system for the production of large quantity of hIPSCs derived cholangiocytes in conditions compatible with the pharmaceutical industry requirements. The resulting cells will be then fully characterized to validate their relevance for modeling Cystic fibrosis and for testing small molecules. Thus, the overall objective of this project is to create a novel drug screening platform for the discovery of therapeutics targeting genetic form of cholangiopathies.

Keywords: cholangiopathies,drug screening,cholangiocytes,liver diseases,genetic disorders
A dynamic database of relevant technologies of bio-waste utilisation (Tech4Biowaste)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Germany,Belgium,Netherlands
Call: Provide insight on emerging technologies for bio-based value chains (H2020-BBI-JTI-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 989781.25
EU funding (EUR): 989781.25
Participants: 3
Project status: CLOSED

Bio-waste is a key waste stream in Europe with a high potential for contributing to a more circular economy. The Tech4Biowaste project will pave the way for deployment of bio-waste technologies and technology configurations by setting-up a database providing a comprehensive technology overview (TRL4-9) for the valorisation of bio-waste (food waste and garden and park waste) into value added applications including chemicals, energy and fuels, food ingredients, and materials. The database content will be determined jointly with actors across the bio-waste value chain. Technology providers can showcase new and emerging technologies, even at lower TRL. Technology searchers can analyse and compare bio-waste valorisation technologies. Both categories of users can assess their commercialisation potential through the associated decision support tool. The Tech4Biowaste database will be composed of unique features based on the latest IT technologies, including artificial intelligence, and use of Open Source software. In order to catalyse significant database usage and future growth, it directly builds on the BBEPP-led Pilots4U network and links with the NOVA-led (parallel-developed) Renewable Carbon platform. A hybrid model will be used to populate the database, combining inputs from the consortium’s publishers’ team, a community of volunteers, and automated scripts and tools („bots"). Tech4Biowaste will mobilise stakeholders (incl. intended users and contributors) for direct involvement (Co-creation, Trainings 1 Testing Panel, 1 Advisory Board) e.g. in the design of the database, in the development of a continuation and expansion scenario and finally for the Business Plan targeting sustained growth and continuity of the open platform.

Keywords: biowaste,valorisation,technologies,database
Engineered nanocarriers for simultaneous anticancer immune response and “switching” of tumor-associated macrophages for intranasal glioblastoma treatment (BraINstorm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Glioblastoma (GBM) remains a non-curable disease due to its high complexity and its position beyond the blood-brain barrier, which precludes access by conventional therapies. The current standard of care includes tumor resection surgery followed by radiotherapy or chemotherapy; an invasive process with a survival rate after five years is less than 5%. Tumor-associated macrophages (TAM) type 2 (M2 macrophages) comprise 30-50% of the infiltrated cells in GBM microenvironment and support tumor expansion. Immunotherapy represents an appealing strategy to treat several cancer types by turning the immune system against tumor cells; tumor antigen peptides (TAAs) recently emerged as an immunotherapeutic approach that can provide for a long-lasting immune response. Immunomodulatory oligonucleotides can “switch” M2 macrophages into M1 macrophages that produce an anti-tumoral effect. The BraINstorm (Brain INtranasal storm) project aims to engineer a hyaluronic acid (HA)-based combination conjugates that tackle GBM by the stimulation of the immune system via the delivery of TAAs and an immunomodulatory oligonucleotide (CpG) that promotes M2 macrophage “re-education” generating an “anticancer storm”. In parallel, taking advantage of the intrinsic muco-adhesivity of HA, BraINstorm will explore the nose-to-brain drug delivery, a more patient-friendly route that reduces the invasiveness. Novel combination immunoconjugates will be fully chemical-physical characterized and preliminary in vitro studies will be performed assessing the biocompatibility, drug release, and nasal mucosa barrier crossing in an ex-vivo model. Finally, the prophylactic and therapeutic activity of the HA-based conjugates will be in vivo explored in a clinically relevant GBM in vivo model through intranasal (IN) and local treatment administration with regards to effects on tumor size, immune memory, and survival.

Keywords: immunotherapy,nanomedicine,biomaterials,intranasal drug delivery,glioblastoma,tumor associated macrophages