Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UNLOCKING THE SUPPLY OF RARE EARTH ELEMENTS IN EUROPE THROUGH RESPONSIBLE, SUSTAINABLE AND DECARBONISED INNOVATIVE TECHNOLOGIES (REESOURCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Norway,Portugal,Austria,Greece,Spain,Denmark,Germany,Finland,Romania
Call: Innovative technologies for sustainable and decarbonised extraction (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 5356211.36
EU funding (EUR): 4999236.0
Participants: 11
Project status: SIGNED

Responsible, sustainable and low CO2 footprint mineral extraction is vital for the preservation of our planet. Ensuring responsible supply of minerals, involves addressing the environmental, social, and economic impacts of mineral extraction and developing technologies and know-how to minimize them. Mining within these low-impact boundaries in a world that is putting an increasing pressure on the mineral supply requires developing environmentally friendly, safe, intelligent and resource efficient extraction technologies and methods. REESOURCE will set a sustainable and decarbonized value chain basis for the extraction of Rare Earth Elements (REEs) in Europe, supporting the ambition of the continent to become self-sufficient on REEs. This target will be achieved through a set of actions (scientific, technical, social and financial) that will serve to pave the road for the development of the European mining of the future. These include i) enhancing key technologies of raise mining to foster “invisible mining”, with minimal socioenvironmental impact and lower CO2 emissions’ footprint compared to existing approaches; ii) developing novel formulations based on environmentally friendly chemicals for both, the mineral beneficiation process of REEs and the process water treatment, supporting the recirculation of this resource; iii) developing a novel stabilization technique for tailings, making them suitable for backfilling, stabilizing the mine and avoiding the need of tailing ponds; iv) valorize the tailings through a Circular Economy approach, to make them suitable for expanded value chains as geopolymers for construction applications and composite materials for catalytic and CO2 capture applications; v) assess the social dimension to maximize early social awareness, engagement and acceptance and vi) multiply the project impact through cross-fertilization with other projects and clusters, supporting the mass adoption of UNFC and UNRMS in the raw materials sector.

Keywords: raise mining,sustainability,green beneficiation chemicals,tailings management,zero pollution
ERA TALENTS FOR BOOSTING AND BALANCING BRAIN CIRCULATION (TBrainBoost)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Slovenia,Germany,Belgium,Malta
Call: Fostering balanced brain circulation – ERA Talents (HORIZON-WIDERA-2022-TALENTS-03, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 1932872.5
EU funding (EUR): 1932872.5
Participants: 9
Project status: SIGNED

The overall objective of the TBrainBoost is to boost international and intersectoral mobility and improve links between academia, business and society in the field of healthy aging. TBrainBoost will achieve this through a series of secondments between academic institutions and businesses working in the field of healthy aging, and a number of educational activities. Based on our methodology, researchers from this multidisciplinary field will enhance their entrepreneurial skills and competences while bringing their valuable research expertise to the industry, while R&I talents will gain new insights and skills to create structural changes that are required to set strong foundations for academy-business collaboration for the future. All intersectoral secondments will also put emphasis on benefiting institutions from widening countries, namely empowering talents from Slovenia and Malta with opportunities to learn from colleagues in Germany, the Netherlands and Belgium. Ultimately, the TBrainBoost project will create a reality where scientists and R&I talents from all parts of the spectrum intuitively share knowledge, experience and skills to boost their personal profiles, work for the benefit of the aging society, and drive our economies.

Keywords: academia industry collaboration,reversed brain drain,aging,ageing,lifelong learning,entrepreneurship,seconded experts,movement science,skills,competences,improved public health
Moving healing plants: Epidemic histories and networks of care along the Amazon river (MovingHealingPlants)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Brazil,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2029-04-30
Duration (months): 42.0
Total project cost (EUR): 359120.22
EU funding (EUR): 359120.22
Participants: 3
Project status: SIGNED

Epidemics involve the circulation not only of pathogens, animals and people, but also of healing plants. In a highly innovative approach, MovingHealingPlants explores human-plant-pathogen networks of care emerging in the exchange of healing plants used for epidemic diseases. The project engages a longue durée timeframe from colonial encounters to current urbanisation processes in Amazonia, and extends along the Amazon river axis connecting contemporary Amazonian cities of Manaus (Brazil), Leticia (Colombia) and Iquitos (Peru). With its headwaters in the Andes and flowing into the Atlantic coast, the highly navigated and populated Amazon river has been decisive in the history of medicine and public health in Amazonia and South America. Yet so far, historical accounts are fragmented into colonial or contemporary nation-states borders, or focus on specific diseases or institutions. This groundbreaking project proposes an interconnected fluvial account of the history of medicine and intercultural relationships of care, from the vantage point of the circulation and transformations of healing plants. Drawing from ethnobotany, global health, history, STS and anthropology, this project aims to assemble a history of epidemics and intercultural care in Amazonia, to explore cosmologies and technologies of plant transformations through ethnographic collaborative participatory approaches, and to produce a critical account of emergent networks and boundary dynamics in a field of Amazonian health simultaneously global and locally situated. MovingHealingPlants highlights the relationships Amazonian Indigenous people form with healing plants as persons, in a more-than-human cosmopolitics from where to rethink some of our most pressing anthropocenic predicaments: environmental destruction and urbanization, the emergence of infectious diseases, and the threats to Indigenous forest knowledge and modes of existing.
Learning to Design Sweet Renewable Hydrogels - Development of Experimental Protocols and Deep Learning Models to Decode Complex Structure-Function Relatioships (Sweet2Gel)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-16
End date: 2024-06-15
Duration (months): 25.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Gels are 3D entangled polymer or particle networks that present, simultaneously, solid and liquid-like properties. Gels are widely present in daily life products such as contact lenses, food thickeners, platforms for drug delivery, or wound healing ointments, among others. Carbohydrate-based hydrogels have gathered increasing attention for a wide range of biomedical and industrial applications (e.g. tissue engineering or water decontamination) due to their biocompatible, biodegradable and non-immunogenic features. However, the development of most gel-like materials is currently limited due their high production costs and greatly pollutant manufacturing techniques. In addition, the great structural complexity of gels, where different lengths scales and isotropic and anisotropic phases coexist, limit their characterisation at the molecular and macroscopic scales, thus hindering the design and development of functional gels with tailored properties. High Resolution Magic Angle Spinning (HR-MAS) and solid-state NMR (SSNMR) spectroscopy constitute the most powerful technologies to characterise the structure and dynamics of hydrogels at the molecular level, not accessible by other techniques. The specific objectives of the Sweet2Gel project are (i) to develop novel HR-MAS and SSNMR protocols for the characterisation of carbohydrate-based gels, (ii) to develop predictive deep-learning-based models that allow to decipher hidden relationships between the molecular and macroscopic properties of the gels and (iii) to improve the molecular models of carbohydrate gel particles by a combination of molecular dynamics and deep learning approaches. Hence, the Sweet2Gel Project aims to accelerate the development of a new generation of renewable materials with rationally designed properties for a wide range of applications.

Keywords: solid state nmr,hr mas nmr,carbohydrates,hydrogels,enzymatic synthesis of oligosaccharides,molecular dynamics simulations,deep learning,cellulose,structured water
Monitoring, Investigation and Response to cyber-attacks with an Adaptive digital twiN moDel for Agile services over the computing continuum (MIRANDA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Italy,Greece,Portugal,Germany,Poland,Austria,Cyprus
Call: Secure Computing Continuum (IoT, Edge, Cloud, Dataspaces) (HORIZON-CL3-2023-CS-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 7308925.0
EU funding (EUR): 5990612.5
Participants: 14
Project status: SIGNED

The growing level of interconnectedness of digital services and infrastructures creates tight and recursive security interdependencies between their providers, which are challenging to address due to the fragmentation of cybersecurity operations. This requires each provider to improve the security posture of its suppliers. However, existing practice, largely based on human interaction for disclosing vulnerabilities, reporting alerts, and suggesting remediations, demonstrates to be largely ineffective and risky. The MIRANDA project aims at operationalising awareness and remediation controls for service supply chains, by addressing feasibility, acceptance, and compliance issues. To this purpose, MIRANDA develops a Cybersecurity Digital Twin (CDT) to model and capture the security posture of such interconnected systems, which is used to detect, hunt, and remediate threats and attacks. The CDT will feature: i) functional and topological representation of digital services; ii) bidirectional control/monitoring data flow with real systems; iii) modelling and behavioural prediction of individual components and whole systems; iv) opaque representation of suppliers’ assets based on confidentiality and privacy requirements. The framework also encompasses the necessary security controls to safely exchange data and controls between providers. On top of the CDT abstraction, MIRANDA builds adaptive and automated processes for threat hunting, detection of lateral movements, and eradication of the root causes of attacks. Validation of individual components and the overall MIRANDA platform will be conducted in three relevant Use Cases, covering different platforms for Smart City services. The purpose will be to demonstrate the adaptability to the evolving context and the effectiveness to stop latest-generation cyber kill-chains and lateral movements across digital chains. The Project will also consider the new business and operational models that are required to run the platform.

Keywords: cybersecurity digital twin,security orchestration and automated response,secure smart city,digital service chains
Plankton-like Protocells for Artificial Photosynthesis Targeting Carbon-neutral Energy Vectors (PLANKT-ON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,France,Spain,United Kingdom,Portugal
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2026-09-30
Duration (months): 42.0
Total project cost (EUR): 3102816.25
EU funding (EUR): 3102816.0
Participants: 7
Project status: SIGNED

While mature solar technologies (i.e. photovoltaics, photo-electrochemical cells) cannot simultaneously address the multi-faceted future energy challenge, PLANKT-ON aims to develop a disruptive net-zero emissions technology to both address the global energy demand and reoxygenation of our planet. Inspired by Nature, we propose to assemble the first synthetic plankton-like protocells that autonomously utilise light, water, and CO2 to produce O2 and formate, as a green H2 vector. To this aim, the plankton-like protocells will be shaped as containers of two synergic subdomains mimicking the natural plastids and the CO2-enzyme organelles. The artificial plastid (1st type proto-organelle) will utilise light to oxidise H2O to O2 and reduce a methyl viologen (MV) cofactor, this latter will feed the CO2-rich proto-organelle to selectively produce formate by a cascade enzymatic reaction. We are expecting that this original bio-inspired strategy will open a route to sustainable solar hydrogen. The long term impact is envisaged for scientific innovation in groundbreaking solar-technology, going beyond the conventional photoelectrochemical cabled asset, and readily exploitable for empowering the EU vision for “Smart Buildings as Micro-Energy Hubs” in the world. Fundamental Research advances will be monitored by PLANKT-ON innovation radar activities, protected by our IP policy and disseminated to reach the expected stakeholders and the general public. Multidisciplinary collaboration among the 6 partners, from 4 EU countries, 5 research centres, and 1 technology-based company, underpins the project activities that will target the EU mission. PLANKT-ON counts on the valuable experience of its Scientific Advisory Committee where international renowned scientists from Princeton (USA), Berkeley (USA), Tokyo (Japan) and EPFL-Lausanne (Switzerland) will contribute to the results evaluation and benchmarking in the field of light management, photo-catalysis and green H2 transport.
Novel ferroptosis inducers for the treatment of non-small cell lung cancer (FERADICATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Despite significant advancements in the molecular characterization of certain types of cancer, many of these discoveries have yet to translate into substantial improvements in clinical outcomes. While targeted therapies are available, patients harbouring common oncogenic driver mutations often experience relapse. Prognosis is even poorer for those without identifiable oncogenic driver mutations. In cases with high PDL1 expression, single-agent immunotherapy typically leads to disease progression, whereas patients with low expression levels require additional toxic chemotherapy to achieve comparable outcomes. This underscores an urgent medical need for more effective therapeutic strategies for specific cancer subtypes. Ferroptosis, a form of necrotic cell death marked by the iron-dependent oxidative destruction of cell membranes, offers a pharmacologically tractable avenue for treatment. The strong reliance of certain tumour subtypes on cellular systems to suppress ferroptosis creates exciting opportunities for innovative therapies. We recently identified ferroptosis suppressor protein 1 (FSP1) as the second mainstay in ferroptosis suppression, functioning independently of the main regulator GPX4. Since the genetic or pharmacologic inhibition of FSP1 alone is sufficient to suppress certain tumour types in the in vivo context, FSP1 emerges as a compelling drug target. Here, we aim to further optimize the activity, selectivity, and pharmacokinetic profile of our newly identified FSP1 inhibitor family. We also seek strive to expand our patent portfolio to ensure broad IP coverage. Our primary objective is to identify a new lead compound—or potentially a preclinical candidate—for cancer treatment, thereby advancing FSP1 inhibitors toward preclinical and clinical development. This program has the potential to deliver a substantial value proposition and create opportunities for out-licensing or co-development partnerships.
Bioarcheology of the Late Mesolithic, the last HUnter-Gatherers of Europe (MUGE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-05-02
End date: 2025-05-01
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: CLOSED

Climate and socio-cultural changes are major ongoing concerns in our modern societies, their impacts on past populations are also central to understand the evolution of the human species, its resilience, and its capacity to adapt to new environments. 8200 years ago, the Mesolithic populations (hunter-gatherers) from Portugal faced a climatic event that profoundly changed their environment in a similar way to what is expected to happen in the next decades. In addition to these challenges, they were also confronted with the arrival of migrating Neolithic populations introducing farming, plant and animal domestication, and sedentism, gradually leading to the disappearance of the hunter-gatherer nomadic way of life. MUGE project aims to unveil the life story of the last hunter-gatherers from the Tagus valley (Muge village) in Portugal and to understand whether the environmental, and socio-cultural changes during the Late Mesolithic (ca. 8200-7100 cal B.P.) impacted the composition and health of these past populations. Discovered 150 years ago and representing the largest European anthropological collection for the Mesolithic (more than 250 individuals), humans from Muge are still poorly studied from a biological perspective because of the state of preservation of the skeletons. Cutting-edge imaging techniques will allow us to correct the taphonomic alterations and go into great detail in the analysis of skeletal remains, providing crucial information about the biological profile of the individuals (age-at-death, sex, etc.), the structure of the populations, and their health status. With more than 1000 years of occupation, Muge furnishes an ideal skeletal sample for exploring changes in health status through time and between sexes, adults, and non-adults but also between sites and understand the impact of each change on these populations. This project is the first to combine both palaeodemographic, palaeopathological, and palaeoimaging approaches to the Muge populations.

Keywords: biological anthropology virtual anthropology mesolithic palaeopathology
StarTric - A novel transcatheter medical device to treat Tricuspid Regurgitation. (StarTric)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Tricuspid Regurgitation (TR) is a widespread, undertreated disease affecting 0.4% of Europeans and over 4.0% of those aged 75 or older. Severe TR cases have high mortality rates, with 50% dying within 2 years and 85% within 10 years. Open-heart surgery, the only proven effective treatment, is performed on less than 3% of patients due to its high mortality risk. The majority who receive only pharmacological treatment face significant morbidity and mortality. Current transcatheter solutions, while minimally invasive, are largely ineffective for most patients, with only 1/3 showing satisfactory outcomes after 2 years. There is a critical need for a next-generation transcatheter technology that is as effective as open surgery and accessible to the majority of patients. StarTric addresses this need with a novel tricuspid valve repair device that replicates the successful "clover" surgical technique in a minimally invasive manner. This device joins the free edges of the three valve leaflets at the TV orifice, specifically designed for the tricuspid anatomy and adaptable to each patient's condition. It ensures precise, stabilized implantation with a unique system that avoids chordae tendineae entanglement and allows continuous blood flow. StarTric offers superior therapeutic efficacy, significantly reduces procedural risks and hospitalization periods, and ensures procedural efficiency with a straightforward, quick technique. It also aims for competitive pricing by requiring only one implant per procedure, reducing overall costs. StarTric's innovative design promises to set a new standard in TR treatment, providing a safe, effective, and economically viable solution. With the EIC’s support, StarTric will be able to finance the development of the technology and conduct human clinical trials, ensuring a fully validated and pre-industrialized device that demonstrates its market potential.

Keywords: tricuspid regustgitation,patient health,wellness