Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Formate for Renewable Energy Storage (FRESH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Germany,Denmark,Belgium,Greece
Call: Emerging technologies for a climate neutral Europe (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 2987730.0
EU funding (EUR): 2987729.75
Participants: 8
Project status: SIGNED

FRESH aims to contribute to reducing the European Union’s dependence on fossil fuels for power generation, providing a cushion for the intermittent character of renewable electricity generation leading to stable, more predictable prices for renewable electricity, which is crucial for the future development of large-scale renewable power generation, and therefore, the energy transition. The project will achieve this through the development, construction and validation at TRL 4, of an integrated, cost competitive process for conversion of CO2 to potassium formate using an electrocatalytic process powered by renewable electricity. The highly stable potassium formate generated by the reactor will be stored safely for long periods (from short term or seasonal) in tanks. The subsequent conversion of the stored potassium formate to electricity on demand will use a direct fuel cell system. The project includes development of the individual components (CO2 to formate and formate to electricity), CO2 sourcing and purification and ultimately the construction and validation of an integrated protoype at TRL 4. This will be achieved by the implementation of a series of interconnected work packages. FRESH is structured around five technical work packages (WPs 2-6) and two ‘enabling/value adding’ work packages (WPs 1 and 7), supporting dissemination, exploitation and management activities. FRESH addresses the work program topic by (1) developing a new renewable energy storage technology (2) highly workable concept & approach, (3) implementation work plan & strategy, (4) a validated prototype at TRL 4, (5) participants with excellent track records for project execution and exploitation and (6) comprehensive LCA and TEA and energy market evaluation of this new technology. The consortium consists of 7 partners of which 1 research institute (ICCOM), 4 industrial partners (COVAL, ENGIE laboelec, HYSYTECH, eRisk) and 2 universities (FZJ and DTU) from 5 EU member states.

Keywords: co2 to fuels,fuel cells,formate,seasonal energy storage,renewable energy
Exploring a Dehydrating/condensation enzyme Domain for a Diversified Antimicrobial Peptide Library (DeDAMPL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

Peptides found in nature, such as penicillin, are a vital source of the antibiotics used to combat infections. While many of these peptides possess useful antimicrobial properties, scientists often need to enhance their effectiveness by replacing some of their amino acid components with special, non-natural ones. This modification aims to identify superior antibiotic candidates with improved traits such as solubility, selectivity, and reduced toxicity. One such building block in this process is dehydroamino acids (dhAAs), which not only enable the creation of new functionalities beyond what natural peptides offer but also streamline customization during the design phase. Despite the potential benefits, incorporating these special building blocks into peptides using chemical synthesis presents challenges and inefficiencies due to harsh reaction conditions. In my research project, I am exploring a novel approach for incorporating dhAAs into peptides by studying a unique dehydrating enzyme involved in the biosynthesis of a recently discovered antimicrobial tripeptide. This enzyme plays a crucial role in producing dhAAs-containing peptides with minimal energy input by facilitating a specific arrangement of atoms during the dehydration reaction. By understanding this process better, I aim to develop a more general and efficient method to incorporate dhAAs into peptide structures under mild conditions. The ultimate goal is to produce antimicrobial peptides with enhanced properties, which can be further modified to create a diverse library of peptides with varying structures. This research not only expands our biocatalytic toolkit but also aims to environmentally friendly, cost-effective, and sustainable methods for producing a broader range of antimicrobial peptides.

Keywords: dehydroamino acids,antimicrobial peptides,non ribosomal peptide synthetases,vancomycin resistant enterococcus faecium
A perovskite sustainable photovoltaic system based on device healing and recycling. (PhoenixPV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2271091.0
EU funding (EUR): 2271091.0
Participants: 1
Project status: SIGNED

PhoenixPV aims to develop a sustainable, reparable photovoltaic system using metal halide perovskites (HaP). Climatic challenges require an urgent abrupt growth of carbon-free energy sources, which will unlikely be sustainable if it is solely based on present photovoltaic systems. Their limited reparability and recyclability threaten a mid-term e-waste problem that will damage the environment and menace their social implementation, restraining overall sustainability. While HaP solar cells have demonstrated performance matching the best commercial counterparts, their stability is compromised due to their ionic and chemically dynamic nature, which also leads to potentially hazardous by-products. Our approach will use these drawbacks in our favor. The chemically dynamic nature, rooted in a low formation energy and ionic properties, can be used as leverage to design intrinsic self-healing strategies and extrinsic post-synthetic treatments, reversing degradation defects and restoring initial performance. Concurrently, these properties will be used to capture the toxic by-products in case of operational accidents and design material separation methods for efficient and safe end-of-life recycling. PhoenixPV will elucidate the reversible and irreversible reactions using a high-throughput aging characterization system that enables the parallel evaluation of a large number of devices under independently controlled degradation stressors. Beyond conventional efficiency, the system will integrate in-operando characterization techniques such as impedance spectroscopy, to monitor device health and design the necessary healing actions. While current research aims to slow degradation routes, PhoenixPV seeks to reverse them, extending the effective lifetime of HaP solar cells, reducing associated waste, and establishing a sustainable photovoltaic system. This project holds the key to accelerating HaP commercialization through the design of innovative photovoltaic usage schemes.

Keywords: perovskites,photovoltaics,sustainability,healing,high throughput
Open-Earth-Monitor Cyberinfrastructure (OEMC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Netherlands,Austria,Germany,Serbia,Italy,Croatia,Romania,Spain,Switzerland,Slovenia
Call: Tools to support the uptake and accessibility/exploitability of environmental observation information at European and global level (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-06-01
End date: 2026-11-30
Duration (months): 54.0
Total project cost (EUR): 13780154.06
EU funding (EUR): 12720045.0
Participants: 23
Project status: SIGNED

The Open-Earth-Monitor Cyberinfrastructure will increase European capability to generate timely, accurate, disaggregated, people-centred, accessible (GSM-compatible) and user-friendly environmental information based on Earth Observation data. We will achieve this by building a cyberinfrastructure anchored in FAIR data principles, leveraging and improving our existing platforms OpenEO.org, Geopedia.world, GlobalEarthMonitor.eu, EarthSystemDataLab.net, OpenLandMap.org, OpenDataScience.eu, LifeWatch.eu, XCUBE and EuroDataCube.com. We do this in 3 phases: a) implementation of the computing engine and in-situ O&M data services; b) direct application of the Open-Earth-Monitor to support EU Green Deal and other strategic actions; c) dissemination and engagement of stakeholders & target users through series of open workshops, then revise the tools and adjust them to better fit their objectives and limitations. We specifically target contributing to: operational planning for planting 3 billion trees over the EU by 2030; achieving climate-neutrality by 2035 in the land sector; building back a net-zero GHG emission economy by 2050; achieving UN’s SDGs’; monitoring essential biodiversity indicators; compiling natural capital accounts for private / public sectors; enabling businesses to leverage competitive advantage through the EU Green Deal; increasing the quality of life for European Citizens. We will innovate: 1) implementation of original cloud-based solutions to seamlessly integrate in-situ (point, site) & EO data so that we can produce environmental information at analysis- and decision-ready levels; 2) implementation of fully-scalable Automated Mapping / AutoML frameworks; 3) user-experience-designed data provision and Apps possibly reaching millions of users across EU and globally; 4) financial assessment tools allowing users to directly quantify ecosystem services (SEEA methodology), to identify optimal environmental and climate solutions, & to build business solutions.

Keywords: open data and methods,fair data,data sovereignty,governance,destination earth,green deal,citizen science,ground observations,remote sensing,outcome based monitoring,automated machine learning
Stress-induced structural and organizational adaptations of the cellular translation machinery (RiboStress)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1498832.5
EU funding (EUR): 1498832.5
Participants: 1
Project status: SIGNED

Many cellular and extracellular events cause perturbations of protein homeostasis by affecting either de novo protein folding or by destabilizing already folded proteins. Under such proteotoxic stress conditions, cells engage in various strategies to avoid further damage to the cellular proteome, e.g. by timely modulation of translation activity and specificity, or by resolving the underlying events. Our overall goal is to dissect from a unique structural angle how such damage avoidance strategies impact on the structure and molecular organization of the translation machinery by directly imaging their effects on ribosome structure, supramolecular organization and distribution in a cellular context with cryo-electron tomography (cryo-ET), an innovative imaging approach unique in its capability to pro-vide highly detailed three-dimensional structural information on macromolecular complexes in their cellular environment. Building on my pioneering work in the field of cryo-ET and integrating novel image processing solutions that have recently marked a breakthrough in the field, we will dissect at unprecedented resolution how the cellular translation machinery is remodeled i) after a general heat-shock, ii) during the Endoplasmic Reticulum unfolded protein response and iii) during persistent translational stalling triggering ribosome-associated quality control. Work included in this proposal will provide detailed structural and mechanistic insights into how cells try to counteract an imbalance of protein homeostasis - a hallmark of neurodegenerative diseases. It thus seems almost certain that key concepts emerging from our studies will have direct implications on mechanistic understanding of central pathological principles underlying these diseases.

Keywords: cellular cryo electron tomography in situ structural biology protein synthesis ribosomes stress response ribosome associated quality control
Tracing Ramifications: The Contemporary Artists' Periodical in the Expanded Field of Arts Publishing (RAMIFICATIONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2028-03-31
Duration (months): 42.0
Total project cost (EUR): 336006.72
EU funding (EUR): 336006.72
Participants: 3
Project status: SIGNED

RAMIFICATIONS investigates the central role of the contemporary artists’ periodical in mediating and driving shifts in the art, communication and publishing systems. Since the early 2000s, artists’ periodicals have become sprawling and live structures, engendering new business models and expansive modalities, collaborations and networks. These periodicals, produced by artists as part of their own language and work, offer a rich opportunity to analyse the expanded field of art publishing and to think critically about contemporary art’s fluid, accelerated and networked expressions. Deep art historical questions concerning art’s autonomy, the meaning of public, collectivity, communication and knowledge in current artistic and publishing practices will be explored through a cross-disciplinary, case study and practice-enhanced approach that will offer the theoretical vocabulary and practical tools to comprehend the fluidity and expansiveness that this project aims to investigate. Curating an artists’ periodical exhibition, conceiving and hosting a 4-episode podcast on art publishing and organising an international workshop on expanded publishing, will not only complement the research’s findings, but outline new directions in this growing field of study. By focusing on 3 global artists’ periodicals—e-flux, Chimurenga and White Fungus—the research contributes to the wider goal of giving voice to marginal stories, situated outside of the North-Western axis. Studying and communicating these histories and contributions to the developments of 21st century art is an important step towards changing public perceptions, encouraging inclusivity and correcting inequalities in the way art is interpreted. The GF will be carried out at the San Francisco State University, Università Iuav di Venezia and at the Triennale di Milano to develop my skills and competencies and allow me to become a leading scholar in contemporary art history and publishing.

Keywords: artists periodicals,expanded field,publishing,artistic practice,contemporaneity
Radical Chemistry with the Hydrogen Atom Through Water Activation (H-dot)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Water activation, which allows the transfer of universally abundant hydrogen into value added compounds, is an important research field in modern science. This task has been realized mainly by using transition-metal-based systems. Herein we will use a conceptually novel mild water activation strategy which proceeds through a photocatalytic phosphine-mediated radical process. The active species in these processes is a metal-free R3P-OH2 radical cation intermediate where both hydrogen atoms are used in the following chemical transformation through sequential heterolytic (H+) and homolytic (H•) cleavage of the two O-H bonds. The R3P-OH radical intermediate provides an ideal platform to mimic the reactivity of a "free" hydrogen atom that can be directly transferred to various π-systems to give H-adduct C-radicals, which are eventually reduced by a thiol cocatalyst leading to overall transfer hydrogenation of π-systems, with the two H-atoms of water ending up in the product. The driving force is the strong P-O bond formed in the phosphine oxide byproduct. Hydrogenation of alkenes, arenes and hetero(arenes) will be investigated, also addressing stereoselective reductions using chiral H-donors. Deuteration and tritiation with D2O and T2O as formal reductants will be explored. Experimental studies will be supported by DFT calculations throughout the studies. Polar effects exerted by the H-donors will be studied, which will allow the design of more complex intramolecular and intermolecular reductive cascade reactions comprising C-C bond forming steps. Reactivity of the novel R3P-OH radicals towards various functionalities will be systematically investigated and the reactive functional groups then incorporated into cascade reactions. Atom-economic radical H-transfer isomerization reactions that proceed with P-based catalysts will be developed. Finally, photoactive P-compounds will be used as mediators for water activation in hydrogen atom transfer radical chemistry.

Keywords: radical chemistry,synthetic methodology,stereoselective synthesis,hydrogenation,photoredox catalysis
Climate-friendly and resilient fisheries through innovation and co-learning (INFINIFISH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Norway,Spain,Türkiye,Iceland,Greece,Belgium,Denmark,United Kingdom
Call: Minimising climate impact on fisheries: mitigation and adaptation solutions for future climate regimes (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 4840706.25
EU funding (EUR): 4500000.0
Participants: 17
Project status: SIGNED

The INFINIFISH project will create innovations to monitor and mitigate the impacts of fishing on the climate and enable fisheries to adapt to the consequences of climate change. It will develop and validate technological solutions for the entire fisheries value chain, such as: • fishing gear that reduces fuel consumption and resuspension of carbon from the seabed • data collection technology to monitor fishing operations, catches, and the environment • decision support systems that optimise fishing operations with respect to energy efficiency • fish processing technologies that increase resource utilisation efficiency • novel products that enable the valorisation of currently discarded resources and new fish species The project will also investigate the impacts of climate change on ecosystems and fisheries through model studies, and identify effective climate change adaptations and mitigation strategies in fisheries management. INFINIFISH will carry out case studies in a wide variety of fisheries across Europe to explore and record how collaborative learning by different stakeholder groups can improve the use and uptake of these technical and operational solutions. The result will be a policy action plan that shows how technologies and innovations can be adapted to, and adopted by, particular local and social contexts. This will be key to maximising the impact of INFINIFISH, ensuring that the project will contribute to significant and lasting change in the fishing sector.

Keywords: fisheries technology fishing gears decision support systems fish processing co learning ecosystem modelling
Targeting RANK receptor as a novel therapeutic strategy in triple negative breast cancer (TargetRANK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Breast cancer is the most common malignancy among females in the western world, resulting in nearly half a million deaths annually, mainly due to metastatic disease. Triple negative breast cancer (TNBC) accounts for almost 15–20% of all breast cancers (300.000 women diagnosed worldwide per year) and is commonly diagnosed in women younger than age 40. TNBC remains a clinical challenge due to high rate of relapse, a propensity to form visceral metastasis and limited targeted therapies. Thus, there is an urgent need to identify novel targeted therapies for the treatment of the TNBC. TargetRANK is based on the innovative idea of generating novel drugs targeting RANK receptor – instead of its ligand RANKL – for the treatment of TNBC, as well as a new panel of anti-RANK human antibodies – for research and diagnostic purposes. Small molecule inhibitors generated during the project could plausibly be positioned as a novel targeted therapy for TNBC and anti-RANK antibodies commercialized for research applications due to the lack of specific antibodies on the market. The most important benefits of TargetRANK are based on the unmet need to improve the treatment of TNBC patients, and the economic burden for public health systems generated by standard non-selected and ineffective cancer treatments. In addition, if drugs against RANK prove to be efficient, TargetRANK derived assets could also clinically benefit most of the patients suffering bone metastasis that are currently treated with bone resorption drugs, denosumab and bisphosphonates. Although our products are aimed for breast cancer, they may be therapeutically relevant for other tumors expressing RANK as non-small cell lung cancer. RANK antibodies will allow to stratify patients that might benefit from RANK blocking molecules, improving the existing treatments for skeletal-related events and reducing the main complications associated with life-altering morbidity affecting several types of prevalent cancers.