Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ion ChaNnel SENSors (ICANSENSE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-04-01
End date: 2015-03-31
Duration (months): 12.0
Total project cost (EUR): 161357.2
EU funding (EUR): 149835.0
Participants: 2
Project status: CLOSED

Super-sensitive detection mechanisms offer numerous opportunities for fundamental science in fields such as biophysics and chemistry and are a highly needed advancement for applied fields such as medicine, environmental pollution monitoring and defence. Developing sensors that are even capable of detecting single molecules has therefore become an important field of research. At this moment there is a growing demand for a stable and sensitive molecular sensing method because the available sensing methods are insufficient. Dr. Kocer and her group have developed a sensory device based on biological ion channels. Ion channels are extremely sensitive transmembrane protein pores that open and close in response to chemical, electrical or mechanical stimuli. Dr. Kocer has built unique knowledge and expertise on the channel functioning that allows her to modify the sensory characteristics of these channels towards the detection of a certain analyte. Via a unique fabrication method a sensory chip has been constructed where ion channels can be reconstituted into an artificial bilayer lipid membrane. This has led to the development of a molecular sensing platform able to detect a large variety of analytes at the single molecule level. To maximise the full potential of the ion channels, we will explore in which fields a molecular platform can fulfil major unmet needs and develop a reliable molecular sensing platform. To achieve these goals, we will conduct market research, develop a sound commercialisation strategy, IPR strategy and a product development plan within the ERC PoC project. The project outcomes will be consolidated in a business plan and presented to investors including venture capitalists and other strategic partners.

Keywords: 208814
Accurate EEG source localisation using patient tailored head models (PTS4DEEG)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands,Netherlands
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-06-01
End date: 2015-05-31
Duration (months): 12.0
Total project cost (EUR): 160559.59
EU funding (EUR): 149054.0
Participants: 2
Project status: CLOSED

EEG records electric potential differences from electrodes attached to the human skin. Although multi-channel EEG can be used to localize its underlying sources, clinical application of this technique in, e.g. epilepsy and stroke monitoring, requires long preparation time to acquire electrode position and head shape and is also hampered by the poor knowledge of in vivo skull conductivity. In the ERC advanced project associated to this PoC proposal a large longitudinal EEG study is performed in stroke patients, which inspired us to find a method for deriving a tailored EEG-head model without the above inconveniences. The tailored EEG-head model will require only a limited recording time. This will enable us to accurately calculate the active brain areas also in patients which can only participate for a short time in experiments. It will be an important step to use high density EEG technology for clinical applications. We foresee that the prototype delivered by the end of the project can be developed into a commercial accessory EEG device that can be provided to end users for relatively small add-on price.

Keywords: 291339
safeDNA - self-assembled fluorescence enhancers for the Detection of Nucleic Acids (SAFEDNA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-02-01
End date: 2015-07-31
Duration (months): 18.0
Total project cost (EUR): 167588.56
EU funding (EUR): 149491.0
Participants: 1
Project status: CLOSED

In this project we will prepare the commercialization of a new patent-protected signal amplification scheme for simpler and faster molecular diagnostics of pathogens such as Chlamydia trachomatis (CT). CT causes more cases of sexually transmitted diseases (STD) than any other bacterial pathogen, making CT infections an enormous public health problem throughout the world. Nowadays, diagnosis is commonly carried out using nucleic acid detection by fluorescence readout after polymerase chain reaction (PCR). However, DNA amplification requires technical equipment too sophisticated for application in developing countries or in standard labs in a medical practice. For cheaper, faster and even point-of-care diagnostics, a simpler amplification mechanism for a testing method capable of detecting DNA in small concentration is required. Here, we suggest applying a new and universal signal amplifying approach that does not require any extra steps after target recognition. It relies on direct enhancement of the fluorescence readout signal using a self-assembled nanolens that was invented within the framework of the ERC starting grant SiMBA. The self-assembled nanolens is capable of enhancing the intensity of fluorescent dyes in a nanosized hotspot by more than two orders of magnitude. Further enhancement is conceivable. Braunschweig University of Technology has filed a broad patent application securing intellectual property rights for the project. We will test this direct fluorescence enhancement scheme for the fast and sensitive detection of CT. Therefore, the self-assembled nanolens will be adapted for the detection of a CT target DNA by equipping the nanosized hotspot of the nanolens with probe DNA sequences. The target is then visualized by sandwich hybridization of a second specific, fluorescently labeled DNA strand. We envision an improved test for CT detection: it should be faster, simpler and price-competitive.

Keywords: 261162
Molecular tattooing: azidated compounds pave the path towards light-activated covalent inhibitors for drug development (AZIDRUGS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Hungary
Call:  (ERC-2013-PoC, 2013)
Start date: 2013-12-01
End date: 2014-11-30
Duration (months): 12.0
Total project cost (EUR): 163520.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Until now the greatest limitation in the application of bioactive compounds has been the inability of confining them specifically to single cells or subcellular components within the organism. Our recently synthesized photoactive forms of bioactive compounds solve this problem. We have developed effective chemical synthesis methods to attach an azide group to small drug-like molecules, which makes them photoactive. As a result, light irradiation can induce the covalent attachment of these molecules to their target enzymes. By controlling the timing and position of light irradiation it is possible to confine the effect of these molecules in time and space. It is important to emphasize that azidation is the smallest possible modification (adding 3 nitrogen atoms) that makes a compound photoactive and based on our experience it does not alter biological activities of most of the original compounds. Azidated inhibitors give unprecedented freedom to researchers because the covalent compound-target formations allow them to address questions which could not have been addressed before. Three major advantages are obtained by using azidated compounds 1: determination of small molecule interactome becomes highly effective, especially, the weak interactions can be determined, which was not possible before 2: it improves the pharmacodynamic and pharmacokinetic properties of biological compounds as the covalent attachment prolongs their effect. 3: Recently, we showed that photoactivation can be initiated by two-photon excitation, thereby confining the effect to femtoliter volumes and well-controlled spatial locations. This feature provides unprecedented spatial and temporal control in localizing the effect of biological compounds in cellular and subcelluler level in in vivo experiments. By realizing the need for photoactive compounds, the PI has established Drugmotif Ltd., a spin-off company, which provides the customers with special azidated chemicals for high-tech research.

Keywords: 208319
Structural Change Promoting Gender Equality in Research Organisations (SAPGERIC)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Science in Society
Action type: Coordination and support actions
Countries involved: Lithuania
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-05-09
End date: 2014-05-08
Duration (months): 12.0
Total project cost (EUR): 450397.6
EU funding (EUR): 299996.0
Participants: 1
Project status: CLOSED

The SAPGERIC project aims at organization of LT presidency conference “Structural change promoting gender equality in research organizations”. The main goal of the conference is to reflect the current state of activities at EU level targeted for promoting gender equality in research institutions and enhance the effective dialogue and knowledge sharing between academia, research institutions, funding agencies, researchers, policy makers and society. The concept of the conference includes three closely related aspects: political, institutional and “academic” covering different areas of activity: policy making, governmental, institutional and specific role of scientific society and having different tasks and challenges. The conference is going to: offer the platform for stakeholders for sharing and learning from the best practices gained in promoting gender equality in research; provide the input to European Strategy and sustainability to perpetuate the results and reflect on how the stakeholders should collaborate within. The LT presidency priorities allows to broaden the frame of EU gender mainstreaming policy in research offering the possibility to include gender issues into running international and regional EU programmes closely concerned with research activities. The wide dissemination campaign enlightening the conference and enabling use of modern tools foreseen in the project will lead to raising awareness among research institutions, funding agencies researches and society at large on the best practices modernizing research institutions and promoting gender equality in research. It will contribute to the continuation of conference tasks and objectives in the post project period and ensure the sustainability to perpetuate the conference results through more effective participation of stakeholders from Member States in Horizon 2020, new COST activities and initiatives concerned with inclusion of gender in science related issues in Action plans of EU international and regional non- scientific Programmes such as Eastern Partnership and Baltic Sea Strategy.

Keywords: gender,mainstreaming policy,gender equality in science,structural change in research organizations
A Flexible natural gas membrane Reformer for m-CHP applications (FERRET)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Netherlands,Spain,Italy,Netherlands,United Kingdom
Call:  (FCH-JU-2013-1, 2013)
Start date: 2014-04-01
End date: 2017-03-31
Duration (months): 36.0
Total project cost (EUR): 3202767.0
EU funding (EUR): 1730663.0
Participants: 6
Project status: CLOSED

The potential for fuel CHP units in Europe as a large market in the future is in general well recognised. Although the size of this market is large and is undisputed when the cost targets of m-CHP units is reached, it is often overlooked that it is a very segmented market. All micro-CHP units, as new heating appliances, will have to be certified against the Gas Appliance Directive (90/396/CE). The latest legislation in Europe and some specific countries, which is expected will be adopted by other countries will lead to a broader range of natural gas specifications per country with larger differences of natural gas qualities. - And last and most important: the gas quality is allowed to change more rapidly in time. In future, more oxygen will be present in natural gas. Now, in Europe actions are taken (regulatory actions) to allow even more fluctuations of the gas composition in time over a day. This means that not only the fuel processor should be efficient in reforming NG to hydrogen, but should be also very robust and flexible, reducing the possibility of hot spots and low selectivity when the oxygen content increases. Within FERRET, we will design the reactor, balance of plant and revise the controls to allow the sudden change of natural gas specification that can be expected in the field in the coming years. According to the problems mentioned above, FERRET project will: • Design a flexible reformer in terms of catalyst, membranes and control for different natural gas compositions. • Use hydrogen membranes to separate pure hydrogen and help shifting all the possible H2 production reactions towards the products, thus reducing side reactions. • Scale up the new H2 selective membranes and catalysts production • Introduce ways to improve the recyclability of the membranes. • Integrate the novel reforming in a CHP system • Optimize of the BoP for the novel reforming CHP system • Simulate and optimize of the reformer integration with the entire system.

Keywords: membrane reformer,natural gas reformer,chp,pure hydrogen production
Advanced m-CHP fuel CELL system based on a novel bio-ethanol Fluidized bed membrane reformer (FLUIDCELL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Spain,Netherlands,France,Italy,Italy,Portugal,Netherlands,Switzerland
Call:  (FCH-JU-2013-1, 2013)
Start date: 2014-04-01
End date: 2018-07-31
Duration (months): 52.0
Total project cost (EUR): 4193548.92
EU funding (EUR): 2492341.0
Participants: 9
Project status: CLOSED

FLUIDCELL aims the Proof of Concept of an advanced high performance, cost effective bio-ethanol m-CHP FC system for decentralized off-grid, by improving technology developments from previous EU projects. The improvements will be achieved by development of a) better system integration using a fluidized bed catalytic membrane reactor working at low temperature (<500°C) b)innovative materials;Pd pore filled (PdPF) membrane, low temperature autothermal ethanol steam reforming (AESR) catalysits and c) most advance FC technologies. Low temperature allows lower thermal duty, higher compactness, use of less expensive materials and long term stability. The H2 is produced from bioethanol which is non-toxic, high energy density, easy handling fuel which can be obtained from cellulose or lignocellulose. Compared with standard AESR, the use of a membrane reactor allows operating at lower temperatures while also suppressing the methane formation via the in-situ recovery of H2. The fluidized bed system allows operating at a virtually uniform temperature which is beneficial in terms of both membrane stability and durability and for the reaction selectivity and yield; since the possible carbonaceous depositions are better exposed to contact with steam and, therefore, faster gasified; in addition, the feedstock is in contact with all the catalyst particles and the fluxes and temperatures are homogeneous, avoiding any polarization phenomena along the membrane. The use of the H2-selective Pd membrane, as proposed in FluidCELL, can circumvent the constraint of high temperatures by shifting the equilibriums, allowing higher H2 yield at much lower temperatures. Besides, the possible detrimental erosion of the membrane produced by fluidized bed will be diminished by considering the use of PdPF membranes where Pd is located inside the nanopores of a ceramic support located below a ceramic protecting layer; this innovative membrane will be for the first time used in fluidized bed reactors.

Keywords: micro combined heat and power,micro-chp,atr,palladium membrane,catalityc membrane reactor,pore filled membrane,bioethanol,off-grid,low temperature bioethanol reforming
Pilot Optical Line for Imaging and Sensing (POLIS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: France,France,France,France,France,Belgium,United Kingdom,United Kingdom,Netherlands,Austria,Austria,Germany,United Kingdom,United Kingdom,Netherlands,Hungary
Call:  (ENIAC-2013-2, 2013)
Start date: 2014-01-06
End date: 2018-01-06
Duration (months): 48.0
Total project cost (EUR): 106897023.53
EU funding (EUR): 16034553.53
Participants: 21
Project status: CLOSED

The KET pilot line project POLIS is aimed at maintaining and furthering the innovation capability of CMOS image and optical sensors in Europe. An existing ST CMOS high volume production line, unique in Europe, will serve as the basis of the proposed project. The strategy behind POLIS lies in the development of specific technological modules and to implement them at pilot line level on the existing production line. POLIS will also enable the development of several key demonstrators representative of potential final products serving multiple applications. More specifically, in order to support imaging expansion into new markets (automotive, consumer, medical, security), the project proposes to focus on the following application fields: sensors capturing photons beyond visible wavelength range, focusing on the limits of spectral range (X-ray/Gamma and thermal IR/THz), sensors using Time of Flight (ToF) technology and light emitters based on OLED on silicon technology for micro-displays.

Keywords: pilot line,imaging,sensor,terahertz,thermal infrared,oled,micro-display,time-of-flight,spad,gamma,x-ray,3-stacking
Hydrogen For Innovative Vehicles (HYFIVE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: United Kingdom,Germany,Germany,Germany,Belgium,United Kingdom,United Kingdom,Germany,Austria,Denmark,Italy,Denmark
Call:  (FCH-JU-2013-1, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 39060997.33
EU funding (EUR): 17970566.0
Participants: 17
Project status: CLOSED

HyFIVE is an ambitious European project including 15 partners who will deploy 185 fuel cell electric vehicles (FCEVs) from the five global automotive companies who are leading in their commercialisation (BMW, Daimler, Honda, Hyundai and Toyota). Refuelling stations configured in viable networks will be developed in three distinct clusters by deploying 6 new stations linked with 12 existing stations supplied by Air Products, Copenhagen Hydrogen Network, Linde, Danish Hydrogen Fuel, ITM Power and OMV. The project’s scale and pan-European breadth allow it to tackle all of the final technical and social issues which could prevent the commercial roll-out of hydrogen vehicle and refuelling infrastructure across Europe. Research tasks will ensure these issues are analysed and that the learning is available for the hydrogen community across Europe. Issues include: • Demonstrating that the vehicles meet and exceed the technical and environmental expectations for FCEVs • Establishing best practice on supporting FCEVs in the field, including new procedures for equipping maintenance facilities, training dealers, establishing a spare parts regime etc. • Using the stations in the project to understand progress on solutions to the outstanding technical issues facing HRS • Investigating the challenges of using electrolysers to generate renewable hydrogen • Understanding the impact of operating a network for filling stations operated by different suppliers, with different hydrogen supply modes • Understanding the buying characteristics of the earliest adopters, who will procure vehicles despite high costs and limited infrastructure • Providing evidence on the likely trajectory of the commercialisation of FCEVs in Europe The project will disseminate the results of this demonstration to opinion formers and decision makers across Europe to improve public readiness for the technology and encourage supportive policies and investment decisions.

Keywords: fuel cell electric vehicle hydrogen refuelling station hrs fcev h2 station network renewable hydrogen commercialisation hydrogen roll-out early adopters consumer behaviour tco lca next generation
Hydrogen Contaminant Risk Assessment (HYCORA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Finland,France,European organisations area,Norway,Sweden,United Kingdom
Call:  (FCH-JU-2013-1, 2013)
Start date: 2014-04-01
End date: 2017-06-30
Duration (months): 39.0
Total project cost (EUR): 3842049.0
EU funding (EUR): 2159024.0
Participants: 7
Project status: CLOSED

In HyCoRA project, a strategy for cost reduction for hydrogen fuel quality assurance QA is developed and executed. For developing this strategy, hydrogen quality risk assessment is used to define the needs for hydrogen impurity gas analysis, system level PEMFC contaminant research as well as needs for purification needs in hydrogen production, especially produced by steam methane reforming (SMR). The use of qualitative and quantitative risk assessment enables identification of critical needs for gas analysis development and guides the research work on those issues, which require most attention. The development of quantitative risk model enables implementation of data from other parallel activities in USA, Japan and Korea. The measurement campaigns in hydrogen refuelling stations, as well as in SMR production units, provide quantitative data, which can be used for identification of canary species, when analysed with help of quantitative risk assessment. Essential part of the HyCoRA project is hydrogen contaminant research in PEMFC system level. The research is performed in down-scaled automotive fuel cell systems, which can replicate all the features of full-scale automotive fuel cell systems, including the change of gases in the anode and cathode during the start-stop cycling. The contaminants and levels to be studied are, excluding obvious carbon monoxide, determined using risk assessment with help of automotive advisory board. The main objective of HyCoRA project is to provide information to lower reduce cost of hydrogen fuel QA. However, it will also provide recommendations for revision of existing ISO 14687-2:2012 standard for hydrogen fuel in automotive applications.

Keywords: hydrogen,contaminant,risk assessment,refuelling station,pemfc system,carbon monoxide,canary species