Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pilots for Healthy and Active Ageing (PHArA-ON)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Spain,Estonia,Estonia,Italy,Spain,Italy,Italy,Spain,Austria,Germany,Italy,Germany,Spain,Belgium,Bulgaria,Croatia,Slovenia,Slovenia,France,France,Netherlands,Netherlands,Netherlands,Netherlands,Portugal,Portugal,Portugal,Portugal,United Kingdom
Call: Smart and healthy living at home (H2020-SC1-FA-DTS-2018-2, 2018)
Start date: 2019-12-01
End date: 2023-11-30
Duration (months): 48.0
Total project cost (EUR): 21228033.73
EU funding (EUR): 18835551.25
Participants: 60
Project status: SIGNED

Pharaon’s overall objective is to make a reality smart and active living for Europe’s ageing population by creating a set of integrated and highly customizable interoperable open platforms with advanced services, devices, and tools including IoT, artificial intelligence, robotics, cloud computing, smart wearables, big data, and intelligent analytics. Platform interoperability will be implemented within Pharaon ecosystems and platforms, as well as other standardised platforms within health and other domains (energy, transport and smart cities). Pharaon will consider relevant standards and will contribute to them with the help of the two standardisation bodies of the consortium. Data privacy, cybersecurity, interoperability and openness will be key design principles to pursue through the requirements generated by Pharaon experts. Pharaon will be built upon mature existing state-of-the-art open platforms and technologies/tools provided by the partners, which will be customised and will implement cloud technologies, AI techniques and traditional algorithms for big data intelligent analytics. A user-centric approach will be followed. Pharaon will evolve based on the user feedback and the results from a MAFEIP framework that will be implemented for impact assessment. Both inputs will be used to find innovative solutions through two “open calls”: (1) single solutions, and (2) solutions to be demonstrated in small-scale pilots. Pharaon’s integrated platforms will be validated in two stages: pre-validation and large-scale pilots (LSPs), in six different pilot sites: Murcia and Andalusia (Spain), Portugal, The Netherlands, Slovenia and Italy. A team of partners in each pilot will ensure its right development. A set of development tools will be created and made publicly available to simplify the customisation and integration. These tools and the results of dissemination will spread the generated knowledge to promote the development of new solutions similar to Pharaon.

Keywords: open calls,mafeip,pilots,older adults,smart wearables,artificial intelligence,cloud computing,big data,intelligence analytics platforms,standards,marketplace,privacy,cybersecurity
Towards a synergistic management of Weeds, Insect herbivores and Diseases with their natural Enemies in pesticide-free agroecosystems (WIDE-Synergies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-06-27
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Farming without pesticides is a major challenge for agriculture today. A promising approach is to design agroecosystems that favour pest regulating processes. Weeds, insect herbivores and pathogens are the main pests in cropping systems, and, so far, they have been mostly studied separately. The WIDE-Synergies project will consider them together by hypothesising that there are synergies in simultaneous management of Weeds, Insect herbivores, Diseases, and their natural Enemies (i.e. WIDE) in agroecosystems. The WIDE-Synergies project aims to (i) quantify the effect of pesticide-free farming practices on these pests and their enemies, (ii) identify the synergies and/or trade-offs in their simultaneous management and (iii) assess the effects on crop yield. Two field experiments with cereals will be conducted in parallel at the Wiesengut experimental farm of the University of Bonn, Germany. Both experiments will compare farming practices aimed at controlling weeds without herbicides, and known to also affect insects and diseases: mechanical weeding, intercropping and under-sowing with a living mulch, in addition to two control treatments (i.e. five treatments repeated four times in a randomised block design). One experiment will contain wildflower strips at plot margins as a semi-natural habitat for biodiversity and the other will have bare soil between plots. The abundance and regulation of weeds, insect herbivores and diseases, as well as of their natural enemies, will be monitored in the fields over two consecutive years. Crop yield will be measured at harvest. Treatments will be compared within and between field experiments. The results are expected to be scientifically highly innovative, and of high interest to farmers and their advisers who will be invited to follow the research project and discuss its output. Communication channels will also be developed to inform non-specialists of the research that aims to develop safe and healthy agriculture in Europe.

Keywords: agroecology,organic farming,conservation biological control,mechanical weeding,intercropping,living mulch,wildflower strip,weed,insect,pathogen,competition,predation,field experiment
Renewable Hydride Donors and Their Utilization in Catalytic Reduction and Deoxygenation Reactions (ReNewHydrides)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1999837.5
EU funding (EUR): 1999837.5
Participants: 1
Project status: SIGNED

The production of chemicals, plastics, solvents, etc., contributes to 20 % of the Gross Value Added in the EU, where sales have doubled over the last 20 years. Despite this dynamism, the chemical industry is energy intensive and 95 % of organic chemicals derive from fossil oil and natural gas. To sustain the growth of this industry, the replacement of fossil feedstocks with renewable carbon, phosphorus and silicon sources should be encouraged. Nonetheless, such a sourcing shift represents a paradigm shift: while the development of petrochemistry has relied on the selective oxidation of hydrocarbons, the conversion of renewable feedstocks (e.g. CO2, phosphates, silicates or biomass) requires efficient reduction methods and catalysts to overcome their oxidized nature. Today, no reduction method meets the criteria for a versatile and energy efficient reduction of oxidized feedstocks and the aim of the ReNewHydrides project is to design novel reductants and catalytic reactions to achieve this important aim. At the crossroads of main group element chemistry, organometallic chemistry, electrochemistry and homogenous catalysis, I propose to develop innovative and recyclable reductants based on silicon and boron compounds, and to utilize them to tackle catalytic challenges in the reduction of C–O, P–O and Si–O bonds. The overarching principle is to build a balanced synthetic cycle, where the electrochemical reduction of functionalized and oxidized substrates is ensured by silicon and boron based hydride donors, with a high energy efficiency and selectivity. This project will foster innovative routes in the utilization of renewable carbon, phosphorus and silicon feedstocks. It is therefore of high risk, but ultimately extremely rewarding. The results will also also open-up new horizons in silicon and boron chemistry and they will finally serve the scientific community involved in the fields of organic and inorganic chemistry, sustainable chemistry and energy storage.

Keywords: reduction,transition metals,hydrosilylation,hydroboration,electrochemistry,phosphorus,organometallic chemistry,silicon,boron,hydrides,mechanisms
Finding and Assessing proteIn nano-crystaLs, a Fail fAst STory (Fail Fast)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Switzerland
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

High-resolution protein structures obtained by X-ray diffraction require the production of well-ordered proteins crystals of high quality. However, to produce well-ordered protein crystals, several bottlenecks must be addressed to screen and optimize the thousands of conditions that can lead to crystallization. In this project, we will accelerate the process of protein crystallization by detecting early, i.e., assessing nano-crystal formation and providing immediate feedback, instead of waiting for crystals to grow, thereby saving time and money. We will use nonlinear light scattering that is highly sensitive to crystal formation. In combination with machine learning analysis, we will develop optimization routines to predict the conditions that likely lead to crystallization in a very short time scale, hours, instead of weeks.

Keywords: protein crystallization,protein crystal screening,protein crystal optimisation,nonlinear light scattering,second harmonic scattering,drug screening,x ray diffraction,cryoem
Advancement and Innovation for Detectors at Accelerators (AIDAinnova)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Innovation and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Israel,Austria,Germany,Germany,Spain,Spain,Spain,Italy,Italy,Spain,Italy,Italy,Switzerland,Switzerland,Norway,Norway,Lithuania,Poland,Sweden,Switzerland,Croatia,Slovenia,Norway,Switzerland,France,France,France,France,France,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovation pilots (H2020-INFRAINNOV-2020-2, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 12677812.69
EU funding (EUR): 10000000.0
Participants: 48
Project status: SIGNED

Particle physics attracts a global community of more than 10,000 scientists, and Europe’s leadership, with CERN as its major laboratory, is internationally recognised. Discoveries are technology-driven; more performant accelerators require innovative detectors to unfold their scientific potential, driving available or emerging technologies beyond their limits. The role of industry is rapidly increasing, due to the need for highly specialised equipment and due to the scale of the installations, where thousands or millions of components require industrial-scale infrastructure. AIDAinnova advances the European detector development infrastructures through fostering an intensified co-innovation with industry. Based on the success of the previous EC-funded initiatives AIDA and AIDA-2020, the project as a novel element fully integrates commercial players, 10 industrial companies and 3 RTOs, together with academic institutions into the consortium, which comprises 46 partners from 15 countries. Knowledge transfer will be catalysed through co-innovative work in common detector projects, and it will strengthen the competence and competitiveness of the industrial partners in other markets. AIDAinnova provides state-of-the-art upgrades of research infrastructure such as test beam and irradiation facilities, and it covers all key technologies for future detectors, following the guidance by the European Particle Physics Strategy Update. The focus is on strategic developments at intermediate technological readiness levels TRL 2-7, where developments are not yet as specific to one particular experiment as in the engineering phase, and it also includes prospective R&D at TRL 1. Therefore, AIDAinnova will unfold synergies by bringing together the expertise from communities aiming at various future projects and maximise the use of resources. Through the large leverage on matching funds from national sources the project leads to enhanced coherence and coordination at a European level.

Keywords: particle physics,advanced infrastructures for detector development,novel detector technologies,cross border collaboration,technology transfer to industry,co innovation
Toilet IoT sensor for medical monitoring and wellness tool (Outsense Phase-1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2018-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Colorectal Cancer (CRC) is considered one of the deadliest forms of cancer. CRC incidence and mortality can be reduced through screening. However, screening participation remains suboptimal worldwide, and though early screening is highly encouraged, more than hundreds of thousands die of the disease every year i.e. 50K people died only in The US in 2015. Screening for CRC is the process of identifying polyps that appear years before the appearance of symptoms of the disease. Several tests can be used to screen for colorectal cancers. These tests can be divided into: 1. Tests that can find both colorectal polyps and cancer: These tests look at the structure of the colon itself to find any abnormal areas. This is done either with a scope put into the rectum or with special imaging (x-ray) tests. Polyps found during these tests can be removed before they become cancerous, so these tests may prevent colorectal cancer. These tests are effective but suffer from low compliance. 2. Tests that mainly find markers for cancer: These tests check the stool (faeces) for signs of cancer (usually blood). These tests are simpler, but less accurate and also suffer from low compliance However, currently these tests for early screening CRC suffer from 3 main problems and limitations: 1. Present low accuracy: can miss information (may fail in the detection of polyps, cover partially parts of the colon, false positives, etc.) 2. Create discomfort (Sedation may be needed, side effects –i.e. bloating, cramping- are usual) 3. May require stool handling that leads to low compliance. Clearly, there is a real need for a more accurate and less invasive test that will also increase compliance. Outsense product is built over a successful methodology with 3 fundamental pillars: (i) Optical method with high sensitivity and accuracy through the realization of multiple repetitive tests (ii) seamless solution, not requiring any stool handling, expected to lead to higher compliance (iii) direct commun

Keywords: colorectal cancer,toilet,wellness,early diagnosis
Exploration and promotion of neurogenesis in the adult brain (Neurogenesis)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

It is now well established that new neurons are added to certain regions of the adult brain. There is today considerable interest in the development of regenerative therapies based on modulating endogenous neurogenesis, but it is necessary to better understand these events to assess whether this is rational and realistic. This application takes its initiation in two recent discoveries that we have made: that astrocytes in the mouse striatum give rise to new neurons after stroke or inhibition of Notch signaling (Magnusson et al., Science, 2014) and that neurogenesis is a continuous process in the human striatum throughout adulthood (Ernst et al., Cell, 2014). We propose to characterize the molecular regulation of neurogenesis from striatal astrocytes in detail, and compare these astrocytes with those in other regions to understand why striatal astrocytes are uniquely neurogenic and whether astrocytes in other parts of the brain can be induced to give rise to new neurons. We will, moreover, assess the role of integration of new neurons in the striatal circuitry by inducing neurogenesis in the striatum in adult mice by blocking Notch signaling or by inducing stroke and modulate the activity of the new neurons by optogenetics and chemogenetics. We will, furthermore, study whether striatal neurogenesis is altered in human neurological diseases by retrospective birth dating by measuring the integration of 14C from nuclear bomb tests. We will assess whether inducing striatal neurogenesis in corresponding mouse models of neurological diseases has therapeutic potential. This project will elucidate the molecular regulation of neurogenesis from astrocytes and the neurogenic potential of astrocytes in different parts of the brain, reveal the role of new neurons in the striatum, answer whether striatal neurogenesis is altered in common neurological conditions in humans and reveal whether inducing striatal neurogenesis may have therapeutic potential.

Keywords: adult neurogenesis,striatum,astrocyte
Development of innovative lightweight and highly insulating energy efficient components and associated enabling materials for cost-effective retrofitting and new construction of curtain wall facades (EENSULATE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Germany,Italy,Spain,Italy,Italy,Belgium,Poland,Poland,Poland,Czechia,Netherlands,United Kingdom,United Kingdom
Call: Highly efficient insulation materials with improved properties (H2020-EEB-2016, 2016)
Start date: 2016-08-01
End date: 2021-05-31
Duration (months): 58.0
Total project cost (EUR): 6758353.75
EU funding (EUR): 5201843.13
Participants: 17
Project status: CLOSED

We will validate an affordable (28% reduction of total costs) and lightweight (35% weight reduction) solution for envelope insulation to bring existing curtain wall buildings to “nearly zero energy” standards while complying with the structural limits of the original building structure and national building codes. Two key commercial insulating products: • Highly insulating mono-component and environmentally friendly spray foam, EENSULATE foam, for the cost-effective automated manufacturing and insulation of the opaque components of curtain walls as well as for the significant reduction of thermal bridges during installation (SELENA and EVONIK in cooperation with ULSTER); • Lightweight and thin double pane vacuum glass, EENSULATE glass, for the insulation of the transparent component of curtain walls, manufactured through an innovative low temperature process using polymeric flexible adhesives and distributed getter technology, thus allowing to use both annealed and tempered glass as well as low emissivity coatings (AGC, SAES and TVITEC in cooperation with ULSTER and UNIVPM ). A multi-functional thermo-tunable coating will allow for dynamic solar gain control as well as anti-fogging and self-cleaning properties (AGC in cooperation with UCL). They will enable insulating solutions that Focchi, DAPP and Unstudio will promote with two different levels of performance: • EENSULATE Basic curtain wall modules where the thermal and acoustic insulation will be provided by the novel EENSULATE glass and EENSULATE foam in the spandrel combined with state of the art low-e coated glass; • EENSULATE Premium modules integrating the thermo-chromic coated glass with additional self-cleaning and anti-fogging functionalities. BGTEC will exploit the limited thickness and high insulating properties of the EENSULATE glass to introduce in their range innovative solutions for the fenestration challenges in historical buildings, compatible with the original window frames and sash designs.

Keywords: insulating materials,foams,vacuum glazing,curtain walls,retrofitting