Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bridging the FET Innovation Gap (BRIEFING)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Germany,Hungary
Call: FET-Open Coordination and Support Actions (H2020-FETOPEN-2018-02, 2018)
Start date: 2018-12-01
End date: 2021-05-31
Duration (months): 30.0
Total project cost (EUR): 497750.0
EU funding (EUR): 497750.0
Participants: 3
Project status: CLOSED

“BRIEFING – Bridging the FET Innovation Gap“ facilitates the translation of European research excellence into tangible innovative potential and therefore contributes to the renewal of the basis for future European competitiveness and growth. BRIEFING leverages different ways of exploiting FET research by supporting researchers in their innovation exploration and fostering the connection between the worlds of researchers and different business stakeholder groups. In this respect, the proposal addresses sub-topic "b. FET Innovation" of the FET Open CSA Call. BRIEFING is based on a flexible system of support tools and services that allows for a tailor-made approach to the diverse needs of the different stakeholder groups. In order to ensure this, the range of support services that will be offered to FET researchers can be specifically tailored to the individual demands and includes business and communication trainings as well as matchmaking tools and events, which altogether will be administered through a dedicated online marketplace. The BRIEFING consortium provides the manifold expertise to respond to the diverse stakeholder needs, bringing together innovation service providers backed by large SME networks with a renowned research institution. The partners’ experiences span the provision of innovation services and the dynamisation of innovation ecosystems as well as the involvement of relevant stakeholders from the research and business world. Three subcontracting clusters will append additional business expertise and involvement in key industries.

Keywords: innovation,training,mentoring,exploitation,commercialization,licensing,spin off
Intelligent control system based on smart textiles to reduce pressure ulcer risk by real time measuring of tissue viability and intelligent trigger of prevention strategies adapted to user and context (i-LiveRest)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Denmark
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-01-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim is to convert the functional prototype from FP7 PUMA project into a commercially-ready intelligent control system and to introduce this new solution for Pressure Ulcer (PU) prevention in the European Assistive Technologies market. The novelties of i-LiveRest are a) to measure PU risk in real time based on Tissue Viability (TV) with impedance, pressure, temperature and humidity textile sensors; and b) to decide the best combination of PU prevention strategies based on risk, user and context. It can be embedded on wheelchair and mattresses. i-LiveRest will be the first ICT solution applied to PU risk detection and prevention. PU are preventable but 38% of PU appear using current devices because a) risk, user status and context are not taken into account; and b) PU risk assessment is only based on pressure instead of TV. There is no available solution able to provide the functionalities of i-LiveRest. Target customers are Spinal Cord Injury (SCI) patients, healthcare public bodies and private insurances. On the one hand, SCI will develop a PU during their lifetime and 7-8% will die. i-LiveRest will increase their sitting time, enhancing their independent living. On the other hand, i-LiveRest will reduce public and private costs related to PU treatment (20 B€/year); injuries of professionals due to manual repositioning (2,000 M€/year); and will increase labour force of SCI and their relatives. In Phase 1, we need to: assess the technical and economic viability of industrialising i-LiveRest by optimising components; identify providers; prepare CE mark; identify purchasing agents; contact stakeholders; and elaborate a business plan. In Phase 2, we will optimise i-LiveRest system to reduce components size and costs, achieve CE mark and perform a pilot demonstration in four European countries. i-LiveRest is aligned with key EU global challenges: disability, independent living and job inclusion; reduction of social and health care costs; and increase of labour

Keywords: intelligent control,decision making algorithms,tissue viability smart textile sensors,tetraplegic spinal cord injury,pressure ulcers,prevention,electrical wheelchair,assistive technology
The neural signature of numerosity: Tracking the cerebral correlates of numerical and continuous magnitude extraction with a frequency-based approach (Freq4Num)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Mathematical skills are critical in modern societies and their development has considerable financial impact on the GDP per capita. Moreover, mathematical difficulties are a frequent factor in children’s learning difficulties. The ability to handle approximate large quantities has been identified as a building block of mathematical skills but the mechanism allowing to extract numerical magnitudes (i.e., numerosity) from environmental stimuli is still debated. Most authors agree that humans have an Approximate Number System that specifically processes numerosity. However, a set of objects is not only characterized by its numerosity but also by additional visual information related to its continuous dimensions (e.g., object size). Accordingly, the alternative theory argues that the numerosity is extracted through a weighting of the continuous dimensions of the stimulus. The opposite views cannot be properly tested through classic behavioral and neuroimaging approaches due to the intrinsic correlation between numerosity and continuous dimensions. Freq4Num aims at disentangling the specific cerebral responses to numerosity and to continuous dimensions. This objective will be achieved by adopting an innovative frequency-based approach to specifically measure the neural correlates of both numerical and continuous dimensions, and their potential interaction. More precisely, the project will combine Steady-State Evoked Potentials (SSVEP) paradigms with electro-encephalography (EEG) and Magneto-encephalography (MEG) to 1) test whether the system discriminates numerosity and other continuous dimensions within stimulus sequences, and 2) highlight whether and how the brain builds neural representations of numerosity and continuous dimensions. Freq4Num will considerably develop the career of the experienced researcher by allowing her to bring significant new advances to the field and to foster her independent research skill and international network.

Keywords: numerical cognition,numerosity extraction,fast periodic visual stimulation,quantities,non symbolic,mathematical abilities
Open Researchers (OPENRESEARCHERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Spain,Spain,Spain,Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-04-01
End date: 2017-11-30
Duration (months): 20.0
Total project cost (EUR): 368010.16
EU funding (EUR): 174782.82
Participants: 13
Project status: CLOSED

‘Open Researchers’ is the fifth experience of Andalusia in the European Researchers’ Night. The project is designed to increase the awareness of research as a solution to the numerous challenges faced by citizens all around the world and mainly in Europe. The idea of the project, ‘The future is today: understandable ground-breaking science for a better living’, has been conceived in a time of change, a moment where becomes clearer that we must join efforts to find sustainable, equal, innovative and creative solutions to give answer to the societal challenges. To this end, according to the RRI, it is essential to promote young people’s interest in Science and Research by opening it to general public through its main protagonists, researchers. The project's major strength is the numerous activities taking place on main streets, museums, theatres, and historical buildings of the eight Andalusian cities, the high mobilization of researchers and the involvement of Municipalities, which will have a high social impact in the region. Given the project’s dimensions in a wide region with 8.3 million people, it will be developed with a high and effective presence in terms of human and technical resources, and with the collaboration of the main local institutions, NGOs, private companies, teachers and civil associations. The communication campaign aims at reach every third citizen of Andalusia, and with activities in city-centre venues around 65.000 attendees each year are expected. Fundación Descubre will coordinate this project, based in its experience through the last 7 years working with relevant projects in Spain and fundamentally in its consortium experience in the four editions of this project in Andalusia. The consortium is composed by nine Andalusian universities, the Spanish National Research Council (CSIC), Andalusian Foundation Progress and Health, and the Royal Botanical Garden of Córdoba, all dedicated to higher education, research and Science popularization.

Keywords: societal challenges,andalusia,research,technological development,scientific vocations,understandable science,equal opportunities,horizon 2020,responsible research and innovation rri
KareShare Platform for Effective Collaborative Clinical Care Management (KareShare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The poor efficiency and lack of interoperability of the legacy Hospital Information Systems & Electronic Medical Records modules are creating an urgent need for a holistic health management platform. Unfortunately, data and exam duplications are still common. There is a lack of automatic solutions extracting relevant information from the patient´s medical history. It is also vital to engage and empower the patient to become an active participant in the care process. Based on our 34-year experience in medical ICT we will bring to market a holistic health management platform KareShare that integrates our Hospital Information System modules, with a natively collaborative Electronic Medical Records. It features a Holistic Synoptic Visualisation of patient history based on Natural Language Processing and a Univiewer to display images of different DICOM and non-DICOM modalities, waveforms and videos, while maintaining total data security & confidentiality for the patient. In Europe in 2015 the HIS market revenue is €3.809M, having penetration rates as high as 80% in administrative and financial systems and around 45% in clinical systems while growing at 3.2% CAGR. In the coming years the trend will tweak towards more demand of new HIS solutions because the old legacy systems are not interoperable and the clinicians and administrative staff need to work with several interfaces. Our target client segment are the 4300 small to medium size private hospitals in the EU and we aim to reach 1% of market penetration in 5 years after the completion of Phase 2 project with a revenue of €25.6M by 2022. In this Phase 1 our technical feasibility study will cover issues related to the clinical issues and technical characterisation of the platform; regulatory and administrative issues as well as usability and patient engagement. In our financial feasibility study we will investigate the commercial feasibility of KareShare platform and develop an extensive business plan.

Keywords: hospital information system,electronic medical record,natural language processing,medical imaging,information extraction
RePower: Maintenance-free and cost-efficient fuel for wireless sensors to energy- and resource-saving solutions (RePower)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Czechia,Denmark,Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-07-01
End date: 2018-11-30
Duration (months): 29.0
Total project cost (EUR): 1578931.25
EU funding (EUR): 1105251.0
Participants: 3
Project status: CLOSED

PROBLEM: Buildings are responsible for 40 % of energy consumption and 36 % of CO2 emissions in the EU. Monitoring building health and energy consumption ensures that technical installation and the building perform and minimize actual energy consumption. Monitoring sensors are often wireless sensors placed in the building constructions, making battery changes cost expensive. SOLUTION: The patented RePower solution to harvest energy for the sensors makes installation and maintenance easy and cost-efficient; as it is simply clamped-on any power cable, the sensor is plugged on and then running during the sensor lifetime. A typically battery operated sensor using long life Lithium batteries have a cost of 180 € due to the batteries. A RePower’ed sensor have no maintenance cost due to the RePower supply. PPROJECT: This project develops, tests and demonstrates RePower in building installations. RePower is a patented and non-invasive solution to power the different monitoring sensors in an installation, harvesting energy from the outside of multicore power cables. IMPACT: Three years after market-launch we expect to distribute 1.4 million RePower driven units annual, to public and commercial buildings, generating 256 new employees at ReMoni and our partners. MARKET: Sales is established to professional building operators and production facilities. The global market potential for new wireless sensors nodes in 2020 is estimated to 15 billion units a year for the growing market of the Internet of Things (IoT). EU RELEVANCE: RePower has the opportunity to be an industrial enabler for the EU IoT development, and thereby strength the European competitiveness , with a novel solution to solve the power issue of wireless sensors.

Keywords: energy harvesting,energy efficiency,resource savings,building health,resource monitoring,cost efficient,wireless
Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers (DPR-VAX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-03-01
End date: 2022-05-31
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Neurodegenerative diseases are triggered by protein aggregation in the CNS, but developing therapies has been challenging. Since key disease mechanisms change during disease progression, halting further neuron loss has not been achieved and may not even improve the symptoms and survival. Causal therapy is most realistic for monogenic disease variants. About 10% of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases are caused by repeat expansion in the C9orf72 gene. We have shown that the expanded repeat is translated into multiple aggregating dipeptide repeat (DPR) proteins. Poly-GA, the most abundant DPR species, is a key driver of downstream pathology. A poly-GA vaccine reduces aggregates and almost completely prevents motor deficits in our mouse model. With additional validation and safety experiment we will generate a pharma-ready data package for rapid preclinical and clinical devel-opment of the vaccine as first-in-class drug for prevention of ALS and FTD in C9orf72 carriers. The parallel development of suitable biomarkers to show clearance of DPR aggregates in vivo will greatly accelerate clinical trials. Thus, we will optimize our published immunoassays to allow more sensitive detection of DPRs in patient CSF. Moreover, we will develop our patented DPR monoclonal antibodies into a PET tracer. The solid data package is complemented by internal and external expertise in business development and regulatory affairs to shape an attractive business proposition and create value. ERC-PoC funding will allow us to present the opportunity to potential partners in large pharmaceutical companies and reputable venture capitalists for licensing or spin-off generation. Another proven strategy in the rare disease space would be collaboration with patient organizations to fund initial clinical trials. Preventing fatal ALS and FTD using vaccination in C9orf72 mutation carriers would be cost-effective for society and a blessing for affected families.

Keywords: neurodegeneration,vaccination,prevention,protein aggregates,biomarker,pet imaging,immunopet
SIGNAL PROPAGATION IN SOURCE TO SINK for the FUTUre of earth Ressources and Energies (S2S-Future)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Germany,Switzerland,Switzerland,Norway,Norway,France,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-04-01
End date: 2024-09-30
Duration (months): 54.0
Total project cost (EUR): 4173709.68
EU funding (EUR): 4173709.6799999997
Participants: 11
Project status: SIGNED

Source–to-sink (S2S) systems describe the response of the Earth's surface to tectonic and climatic signals over geological times, from upstream zones of erosion (source) to ultimate deposition (sink). Understanding S2S systems is key to significantly improve human's ability to predict the characteristics of sedimentary accumulations hosting essential societal and industrial resources (geomaterials, energy, minerals, groundwater, waste). Tomorrow’s successful exploration of Earth's resources for future sustainable and responsible growth relies on training the next generation of researchers with a holistic and interdisciplinary approach to S2S systems. The S2S-FUTURE project, closely co-designed by academics and professional partners to enhance societal relevance and employment demand, has 3 major ambitions: - Train 15 ESRs with the highest level of state-of-the-art concepts, techniques, and multidisciplinary knowledge to comprehend complex large-scale S2S systems with creativity, innovation and numerical modelling tools. - Empower these ESRs with acute awareness of career opportunities in both academic and non-academic sectors thanks to selected entrepreneurial skills and involvement into a diverse professional network of world leaders in the domain. - Promote the efficiency of European S2S research and application to meet society needs through the establishment of a dynamic network of professional and the development of legacy tools that will ensure the network's perennity and its expansion beyond this ITN: a yearly S2S Summer School and a EU web-portal for S2S. Europe and the S2S-FUTURE trained ESRs will be at the center of this network, in a unique place to contribute and benefit from future capacity building and breakthroughs of source-to-sink sedimentary research.

Keywords: source to sink,sediment routing system,geomorphology,sedimentology,stratigraphy,tectonics,paleoclimatology,geochemistry,aggregates,oil and gas,geothermy,groundwater,mining,waste storage
Ultra-Fast Molecular Filovirus Diagnostics - Sofia ref.: 115844 (FILODIAG)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,Italy,Germany,Czechia
Call: Rapid diagnostic tests (H2020-JTI-IMI2-2014-02-single-stage, 2014)
Start date: 2015-02-01
End date: 2017-12-31
Duration (months): 35.0
Total project cost (EUR): 2260105.0
EU funding (EUR): 2260105.0
Participants: 4
Project status: CLOSED

There is an urgent need for fast and accurate diagnostic tests in the current Ebola crisis. The rapid diagnosis of EVD during early and late stage of infection is a decisive step for risk assessment and for guidance to physicians to take the necessary decisions to limit the spread of the infection, and to safely nurse the infected patients. While fast and easy-to-use tests usually rely on immuno-diagnostic approaches, they typically lack high sensitivity and specificity. The gold standard for accurate diagnostics, (Real-Time) PCR, however, is limited in terms of processing time, high costs, and in most cases also in terms of ease of use and the need of special laboratory facilities. The aim of this project is to provide an ultra-fast and accurate molecular diagnostic instrument that can perform a molecular Ebola test within 10-15 minutes. Patients, suspected of Ebola Virus Disease (EBD), due to fever and/or other clinical signs, could be rapidly and accurately tested at the Point-of-Care by withdrawal of blood, or less invasive fluids, such as saliva or urine. The core technology of this proposal is based on laser-heated nanoparticles (Laser PCR), overcoming the time-limiting step of heating and cooling the reaction sample in conventional PCR allowing for drastically reduced turn-around times. The project partners (GNA, INMI, MUB, EMG) have the competence to integrate sample preparation with virus-binding magnetic particles, ultra-fast molecular diagnostics with Laser PCR, test the system in a biosafety level 4 laboratory in Rome, Italy, and thoroughly conduct field testing in a medical care centre in West Africa (Sierra Leone). A tentative Ebola Laser PCR assay has already been set up, detecting 10 target copies of synthetic DNA oligos, corresponding to the Ebola genome sequence, in less than 12 minutes. The FILODIAG project will deliver a potentially multiplexed diagnostic system fast enough for point-of need testing of incoming patients at low-resource

Keywords: rapid,laser pcr,magnetic beads,field tests,bsl4,ultra fast,molecular diagnostics,ebola,filoviridae