Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the Roles of the Salvage and De Novo Pathways of Nucleotide’s Metabolism in Mitochondrial DNA Maintenance (MITO-GARAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: SIGNED

Mitochondrion is a crucial integrator of various cellular metabolic pathways in the intermediary metabolism, and it has the ability to produce oxidatively-derived energy by the oxidative phosphorylation (OxPhos) system. The OxPhos complexes are composed of subunits encoded by both mtDNA and nuclear DNA (nDNA), and mutations in either class of genes can cause severe OxPhos defects, leading to mitochondrial diseases (MD). Remarkably, the mitochondrion is unique among the cell's organelles, as it contains its own DNA (mtDNA). The deoxynucleotides triphosphates (dNTPs) required for mtDNA synthesis are produced by the salvage pathway in the own mitochondrion. However, recent data suggest that de novo pathway for dNTPs synthesis is also critical for mtDNA replication. In fact, defects in enzymes involved the de novo pathway have been recently reported as causes of MD. MITO-GARAGE aims to better understand how the different pathways involved in dNTPs metabolism work in mtDNA replication and to develop therapeutic strategies when it is impaired. This will allow us to better comprehend basic metabolic processes and their integration in pathophysiological and therapeutic aspects for MD. With that purpose, we will use unique in vitro and in vivo models with defects in RRM1, GUK1 and COQ2, and a combination of modern and classical reductionist approaches. MITO-GARAGE will be carried out in international-recognized groups at Columbia University and the University of Granada. The workplan includes one key short visit to learn an specific technology; training in basic-clinic and public-private partnerships; training in academic skills; scientific and non-scientific work-packages, tasks, milestones and deliverables; a contingency plan; the landscape for results’ exploitation and the development of a career plan. Overall, MITO-GARAGE clearly define the four-way transfer of knowledge and will achieve significant advances in the progress of the hyper-personalized medicine.

Keywords: mitochondria,mitochondrial diseases,rare diseases,therapies,personalized medicine,nucleotide metabolism,mtdna depletion,mouse models,tissue specific mechanisms,mitochondrial metabolism
Reactivity and Transport of Hollow Magnetic Particles Explored with Microfluidics (RT-MAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

RT-MAP will develop novel hollow iron oxide particles and assess their reactivity, stability and mobility under flow through porous media. Such hollow magnetic particles (h-MPs) have aroused great interest for their potential to encapsulate and control reagent release for environmental remediation and/or heterogeneous catalysis. Most available reactivity assessment studies rely on the interpretation of breakthrough curves measurement at the outlet batch tests or column experiments and do not allow a direct visualization of pore scale transport and reaction phenomena. RT-MAP will develop novel microfluidic cells, providing a new window on coupled flow and reaction processes at the microscale, a key to modeling and predicting macroscale reaction rates. The combination of complementary expertise of the fellow (material synthesis and characterization), and the supervisor and co-supervisors (molecular geochemistry, reactive transport in porous media, microfluidics) will offer a unique opportunity to address these emerging scientific questions. We will thus fabricate microfluidic cells providing spatially resolved concentration fields under flow through reactive porous media. Cutting-edge spectroscopic techniques will be used to investigate molecular interactions between reactive particles and two types of fluorescent compounds. The first is a fluorescent probe (fluorescein) used to functionalize particles and make them traceable by imaging in microfluidics. The second is an environmentally relevant antibiotic (ofloxacine) to study the reactive properties of h-MPs with emerging contaminants. Advanced microfluidic devices and fluorescence imaging will provide the first spatial resolved images of h-MP concentration at microscale under different flow rates and solution chemistry. RT-MAP will thus lead to key innovations at the interface of environmental chemistry, geosciences and microfluidics, placing the fellow on a strong footing to find an independent research position.

Keywords: magnetic particles,solute transport,reactive transport modelling,microfluidics,redox processes,spectroscopy,environmental fate and transport,organic coating
A deep learning-derived, shear wave elastography biomarker for cancer therapy prediction (DL-ElastoMark)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Cyprus
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 148488.0
EU funding (EUR): 148488.0
Participants: 1
Project status: CLOSED

The efficacy of standard cancer therapies varies, and while some patients respond to a particular treatment, other patients do not gain any benefit. In response, an era of individualized cancer treatments is emerging which are based on the identification of biomarkers that characterize the state of a tumor. Many solid tumors (e.g., breast cancers and sarcomas) stiffen as they grow within a normal tissue. Tumor stiffening is a known factor leading to compromised efficacy of therapeutics. Repurposing drugs in order to alleviate tumor stiffness before the initiation of therapy has been tested in preclinical studies and has recently made it to the clinic. Despite recent success of these strategies, optimization of their application is understudied. Here, we aim to harness the power of deep learning (DL) methods in order to construct a robust biomarker based on ultrasound shear wave elastography (SWE). The biomarker will aim to: (i) predict the tumor’s response to treatment with chemo- and immuno-therapy and (ii) monitor treatment outcomes, in the case of strategies that target tumor stiffness. The project will capitalize on the existing strengths of the applicant in medical image processing and DL and the expertise of the host in tumor mechanopathology and in vivo experiments. In past experiments, the host acquired a large number of SWE tumor data, which will enable the development of the DL biomarker. Through the experimental part of the project, additional data on murine cancer models will be acquired enabling the validation of the biomarker. Formulation of the developed DL-derived biomarker in a user-friendly software will allow for potential clinical translation and further exploitation through IPR. The applicant will acquire new knowledge in the fields of cancer therapy, tumor biology and in vivo experimental design. The attained knowledge and skills will be instrumental to the applicant’s ambition to lead the field of artificial intelligence in biomedicine.

Keywords: deep learning,ultrasound shear wave elastography,biomarker predictive of tumor response,tumor mechanical properties
Safety and efficacy of Dolutegravir and EFV400 for pregnant and breastfeeding women - a randomized non-inferiority clinical trial (PREGART)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Sweden,Italy,Uganda,Ethiopia
Call: Funding to successfully finalise EDCTP2-funded clinical trials that were negatively impacted by the COVID-19 pandemic (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 4
Project status: SIGNED

PREGART is a multi-national Phase-4 randomized clinical trial aimed at identifying optimal antiretroviral treatment (ART) regimens by comparing the efficacy and safety of dolutegravir- versus low-dose efavirenz (EFV400mg-) based first-line cART regimens in 1156 HIV-infected pregnant women and infant pairs in Ethiopia and Uganda. The primary outcomes are undetectable viral load at delivery, prevention of mother-to-child transmission of HIV, and adverse pregnancy outcomes. The COVID-19 pandemic significantly hampered all trial activities, including patient enrollment, follow-up, regulatory approvals, and trial site initiation. All clinical trial activities were suspended to protect the safety of study participants (pregnant women and infants) following the stay-at-home orders during the initial wave (March - September 2020) and intermittently during the subsequent waves of COVID-19. Furthermore, the PREGART trial activity was affected by the civil war in northern Ethiopia (2021/22) and the Ebola disease outbreak in Uganda (2022/23). Efforts have been made to mitigate these challenges by opening new trial sites, adapting protocols, and utilizing decentralized trial approaches to increase the participant recruitment rate. To complete the PREGART clinical trial, we request another 36 months and 1.8 million euros to compensate for time and incurred financial loss due to the COVID-19 pandemic, the civil war in Ethiopia, and the Ebola outbreak in Uganda. Completion of clinical trial activities and data analysis will fulfill our obligation to protect the scientific quality and data integrity, ensuring our commitments to study participants and meet PREGART trial objectives - to provide comprehensive and statistically powered evidence for policymakers on the maternal and infant safety and efficacy of dolutegravir and EFV 400mg containing cART. The study will contribute towards optimizing WHO and regional ART guidelines for HIV-infected pregnant and breastfeeding women.

Keywords: hiv,pregnant and breastfeeding women,pregnancy outcome,antiretroviral treatment
Vibrating Membrane Gauge for Wide-Range Pressure Measurement (VIMEG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Numerous industrial and scientific processes are conducted under vacuum conditions for improved cleanliness and control. Monitoring the vacuum level is crucial to ensure consistent process results. Ionization gauges represent the state-of-the-art for measuring residual gas pressure at high and ultrahigh vacuum levels. Here we propose to establish an alternative pressure gauge based on measuring the gas friction experienced by a nanomechanical membrane resonator with ultralow intrinsic damping. This approach promises more compact, durable, and accurate gauges that cover a wider pressure range than conventional ionization gauges.
Exposing Hidden Electronic Configurations in Atomically Thin Superstructures with Extreme Light (EXCITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1999899.0
EU funding (EUR): 1999899.0
Participants: 1
Project status: SIGNED

Light-induced phase transitions in solids present a tantalizing opportunity for controlling the constituents of matter. An intense optical excitation with a duration on the order of femtoseconds can trigger nonthermal electronic and structural configurations, switching the excited material into a hidden phase that may be exploited to realize new technologies such as ultrafast memory devices. A general picture of the microscopic processes underpinning hidden phases has not been established. Their existence has therefore only been exposed in a handful of systems, presenting a major obstacle for achieving on-demand quantum materials with light. Drawing inspiration from these unique systems, I hypothesize that materials with a strongly correlated phase that is pinned by a two-dimensional superstructure provide a trajectory to a light-induced hidden phase. The objectives of EXCITE are (A) to establish the experimental parameter space to determine the electronic structure of hidden phases in bulk and single-layer correlated transition metal dichalcogenides, (B) to demonstrate the existence of hidden phases in optically excited moiré superstructures that simulate strongly correlated behavior and (C) to exploit the wide tunability of these systems in order to disentangle the general microscopic degrees of freedom that govern the trajectory into a hidden phase. The objectives will be accomplished by establishing a state-of-the-art experiment to optically excite in situ prepared materials and probe their electronic structure during phase transitions with nanoscale spatial resolution and femtosecond time resolution. These ground-breaking capabilities will be realized by integrating a high-power laser system with my new synchrotron beamline for nanoscale photoemission spectroscopy (nanoARPES) at the ASTRID2 light source, Aarhus University. My experiments will enable me to critically assess basic assumptions in the field and move the boundaries of ultrafast science.

Keywords: 2d materials,charge density waves,mott insulators,van der waals heterostructures,twistronics,synchrotron radiation,phase transitions,ultrafast dynamics,superconductivity,angle resolved photoemission spectroscopy
Multiscale Characterisation and Simulation for Hydrogen Embrittlement Assessment: Development of an Open Knowledge Platform to Foster Capability Integration (HyWay)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Finland,Norway,Germany,Latvia,Spain,Belgium,France,Ukraine,Italy,Cyprus
Call: Adaptive multi-scale modelling and characterisation suites from lab to production (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6947437.5
EU funding (EUR): 6947437.5
Participants: 18
Project status: SIGNED

HyWay aims to develop adaptive multiscale material modelling and characterisation suites for assessing interactions between hydrogen and advanced metallic materials and demonstrate their capabilities on hydrogen storage and transport components. Advanced materials application like hydrogen technologies is essential for achieving the EU carbon neutrality goal. However, deploying hydrogen technologies needs a tremendous effort to complete the infrastructure, requiring efficient material assessment suites, enabling industries to be more effective in developing and working with materials. Furthermore, since hydrogen is stored and transported in several forms, the material assessment suites must be flexible and capable of revealing hydrogen-material interactions in various conditions. The HyWay suites contain 3 key modules: Physical realm, Virtual world, and Data and knowledge management platform (DKMP). The Physical realm will advance experimental capabilities to reveal hydrogen-material interactions by compiling characterisation methodologies across length scales. The Virtual world will develop a multiscale and multiphysics materials modelling framework for disclosing how hydrogen alters changes in advanced materials under various service conditions. The Physical realm and the Virtual world are interdependent and complement each other through the data exchange between modules. We will establish the DKMP to facilitate the data exchange and merge material research disciplines. HyWay will ensure the productive allocation of investments required in constructing the hydrogen infrastructure. We will strengthen European capability in steering green transition with digital technologies and future emerging enabling technologies and ensure an open strategic autonomy by supporting the transformation of the EU energy mix to be dominated by hydrogen. The consortium comprises renowned experts from academia and industries across the EU and will support Ukraine on its European path.

Keywords: hydrogen storage and transport infrastructure,hydrogen material interactions,multiscale materials characterisation,multiscale and multiphysics materials modelling,data and knowledge management
Who Needs Virtue? The Early Academy and the Way to Happiness (WNV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

‘Who Needs Virtue? The Early Academy and the way to happiness’ (WNV) aims to show that the theories developed in the Early Academy - the phase of the Academy immediately following the death of Plato - are crucial for understanding the dynamics and interplay of the origin of the debate on virtue and happiness in the 4th century BCE. How do we human beings attain happiness? And to what extent, if any, does virtue contribute to happiness? These questions lie at the heart of Western ethics from as early as the 5th century BCE. In antiquity, there were two major, competing answers to the question of how happiness and virtue are related. The first model, advanced by Plato, suggests that virtue (arete) is a sufficient condition for human beings to secure happiness (eudaimonia). Differently, Aristotle holds that virtue is not sufficient for someone to live a happy life, for other (non-moral) goods (e.g., health, wealth and friends) are also required. These two models are usually examined in terms of their similarities and differences. Yet, what is missing from the picture is an account of the framework in which this debate originally emerged and the discussions that contributed to shaping these responses. WNV seeks to fill this gap by advancing the hypothesis that coeval developments in ancient virtue ethics can be more effectively understood as the result of a dialectic with and in the backdrop of the discussions of virtue and happiness conducted by the first generation of Plato’s students.

Keywords: history of platonism classical philosophy early academy ancient ethics
Plasma reconfigurable metasurface technologies (PULSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Greece,Finland,Belgium,Spain
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2969980.0
EU funding (EUR): 2969980.0
Participants: 8
Project status: SIGNED

PULSE pursues the ambitious goal of defining a new technological horizon for implementing reconfigurable electromagnetic devices by unifying the research domains of metasurfaces with the plasma physics. The advantages retuned by plasma when combined with metasurfaces are multiple: first, plasma allows overcoming the main limitations of conventional reconfigurability strategies and achieving unprecedented tunability rate at high frequencies. Additionally, plasma enables conceptually new scenarios in which the individual properties of the meta-atoms, and even their shape/size, can be time-modulated. The project, thus, is aimed to fully merging two different research fields for establishing a radically new technology (plasma metadevices) offering unprecedented possibilities. To address this vision, several science-to-technology breakthroughs are proposed, including tunable lenses for antennas, non-reciprocal devices in waveguide technology and four-dimensional (4D) devices, in which the variation of the shape over the time becomes an additional degree of freedom to achieve new effects at the fundamental level. PULSE's technological goals are beyond the state-of-the-art and outside any scientific and technological roadmap of the involved scientific communities. In addition, it is expected that PULSE will also have a dramatic economic and society impact. The unprecedented functionalities of the plasma-based metadevices, in fact, can address the increasingly stringent requirements of the next-generation telecommunication systems. To achieve PULSE's ambitious scopes, the Consortium has been built for success in terms of industry and academic excellence. We have brought together a Consortium with a true European dimension, with eigth beneficiaries from Italy, Spain, Finland, Greece and Belgium. Our expertise is interdisciplinary, complementary and characterized by appropriateness of equipment in all the involved scientific and technological domains.

Keywords: plasma metasurfaces,reconfigurable metasurfaces,high frequency devices