Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PHOENIX: Precision Human Organs-on-chip for Enhanced Neuro-muscular and Cardiac Studies (PHOENIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Germany,Spain
Call: Innovative non-animal human-based tools and strategies for biomedical research (HORIZON-HLTH-2024-TOOL-05-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7819609.14
EU funding (EUR): 6495815.56
Participants: 9
Project status: SIGNED

PHOENIX aims to revolutionise biomedical research by developing the next generation human-based Organs-on-chips (OoC). OoC is a promising technology potentially able to outperform conventional preclinical models in providing patho-physiologically relevant setting for investigating human diseases, thus tackling the limited translational value of animal testing. OoC wide adoption is currently hampered by poor maturation of cellular models and shortage of non-destructive readout methods. PHOENIX will take current OoC platforms to the next level, overcoming such limitations by integration of core technologies already validated by the Consortium, namely Electric Recording (3dMEA), Force Sensing (3dFORCE) and Mechanical Stimulation (3dMECH). Two platforms will be developed: i) μHeart, to model functional cardiac tissues, and ii) μNMC to model neuro-muscular circuits. PHOENIX ecosystem will be completed by satellite products and qualified against specific contexts of use in clinically and industrially relevant environments. PHOENIX potential will be showcased with two genetic pathologies as demonstrators: LMNA-cardiomyopathies and Freidreich’s Ataxia, conditions in which electrical instability and mechanical impairment play important roles. For each platform, two versions will be released (Base and Pro), addressing the need of identified customer segments (research labs and Pharma/Biotech). In line with the 3Rs, PHOENIX platforms represent the ideal clinically relevant tools to test drugs and gene therapies, leading to faster/safer development processes, reducing the need for animal testing. Robust dissemination, exploitation and communication activities will address both key stakeholders (OoC players, end-users, end-beneficiaries and regulatory bodies) and society at large, fostering acceptance, adoption, economic viability and regulatory compliance. PHOENIX will last 4 years with a Consortium comprising 9 partners (Academic, SMEs and LEs) from 4 EU Countries.

Keywords: heart on chip,neuromuscular circuits,3d cell culture,mechanical stimulation,electrical recording,mechanical sensing,mea,genetic disease,gene therapy
SCALE - Smart Charging ALignment for Europe (SCALE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Netherlands,Belgium,Germany,France,Norway,Sweden,Greece,Hungary
Call: System approach to achieve optimised Smart EV Charging and V2G flexibility in mass-deployment conditions (2ZERO) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 9991615.0
EU funding (EUR): 9991611.0
Participants: 31
Project status: SIGNED

SCALE will enable and facilitate the mass deployment of electric vehicles and the accompanying smart charging infrastructure. To do so, SCALE will systematically assess customer expectations, identifying EV-users’ preferences, existing obstacles and potential incentives to charge smartly. By this, SCALE ensures co-creation and -optimisation, preparing for an open smart charging & V2X eco-system that equally benefits users, cities & regions, businesses, and society at large. SCALE brings together leading existing research & innovation initiatives and smart charging demonstration testbeds from across Europe forming a unique knowledge & collaboration platform. The consortium builds upon existing technologies, standards, and protocols as much as possible and focuses on research and developments of the missing and/or incomplete elements and links. The 29 project partners and associated organisations have been carefully selected and have all the necessary scientific, practical, and technical expertise to develop, test & validate and exploit smart charging & V2X solutions. Partners cover the entire value chain and comprise of leading European OEMs, DSO/ TSOs, CPOs, e-mobility service providers, public authorities, research & knowledge partners, EV user associations and European networks & multipliers. Multiple SCALE consortium partners are directly involved in EC’s European Alternative Fuels Observatory & other important European e-mobility initiatives (STF, Clean Bus Europe). SCALE creates a critical mass to develop the technological, regulatory, organisational and legal readiness that is needed for a mass-market. SCALE will initiate a Joint European Procurement for V2X chargers based on open standards, run by 5 European cities. The Open V2X Alliance ensures SCALE’s legacy during and after the project’s lifetime.

Keywords: smart charging,v2x,interoperability,open protocols,grids,ev drivers and users
Improving CAR-T cell therapies through AAV-mediated genetic engineering (INVIVO-CAR-T)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1503155.0
EU funding (EUR): 1503155.0
Participants: 1
Project status: SIGNED

T cells expressing chimeric antigen receptors (CAR) have transformed cell therapies against some hematological cancers. As a postdoc, I evolved a synthetic adeno-associated virus (AAV) with tropism against murine T cells, providing a unique tool to study gene targeted T cells in immunocompetent cancer models. In this proposal, capitalizing on my break-through, I will develop novel strategies to generate gene targeted CAR-T cells in vivo, optimizing AAV delivery in immunocompetent mouse models and combining these methods with technologies for Cas9 delivery for T cell-specific gene editing. The ultimate goal of my proposal is to develop methods that can be translated to clinical trials in humans. Therefore, I will establish a humanized mouse model that allows for targeting of human T cells in vivo, in which key findings from this research project will be translated for proof-of-concept experiments. As the first ever study of gene targeted T cells in vivo, this ground-breaking research will provide in-depth profiling of in vivo engineered CAR-T cells and their therapeutic potential. This study is a necessary first step forwards toward accessible and affordable in vivo generated CAR-T cell therapies in humans. Furthermore, to extend the use of CAR-T cells against solid tumor, I have developed an AAV-based platform to perform pooled knock-in T cell screens in immunocompetent solid tumor mouse models. For this research proposal, I have designed a library of synthetic costimulatory receptors to be expressed with a CAR at the Trac locus to improve T cell fitness and persistence. By combining advanced T cell engineering with analysis on single-cell level, these pioneering experiments will answer crucial questions for T cell therapies and tumor biology. To succeed with my ambitious and unconventional proposal, I plan to join the Department of Medicine, Huddinge, at the Karolinska Institute. Building a collaborative team in an excellent translational research environment.

Keywords: genetic engineering,aav,in vivo delivery,gene targeting,car t cells therapies,synthetic receptors
Open collaboration and open Digital Twin infrastructure for Green Smart Shipping (DT4GS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Belgium,France,Italy,Spain,Netherlands,Greece,Cyprus,Ireland,Poland
Call: Digital Twin models to enable green ship operations (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 6987333.0
EU funding (EUR): 6987331.0
Participants: 23
Project status: SIGNED

DT4GS is aimed at delivering an “Open Digital Twin Framework” for both shipping companies and the broader waterborne industry actors to tap into new opportunities made available through the use of Digital Twins(DTs). The project will enable shipping stakeholders to embrace the full spectrum of DT innovations to support smart green shipping in the upgrade of existing ships and new vessels. DT4GS will cover the full ship lifecycle by embracing federation of DT applications as well as utilising DTLF policies and related shared-dataspace developments for the sector. DT4GS applications will focus on shipping companies but will also provide decarbonisation decision-support system for shipyards, equipment manufacturers, port authorities and operators, river commissions, classification societies, energy companies and transport/corridor infrastructure companies. DT4GS’s objectives are to: 1. Support shipping companies in achieving up to 20% reduction in CO2e with a 2026 horizon, by developing and deploying real-time configurable DTs for ship and fleet operational performance optimisation in 4 Living Labs involving shipping companies, with different vessel types, and establishing fully validated industry services for Green Shipping Operational Optimisation DTs expected to be adopted by 1000+ ships by 2030. 2. Establish a comprehensive zero-emission shipping methodology and support Virtual Testbed and Decision Support Systems that address both new builds and retrofits comprising: a. A DT4GS (Green Shipping) Dataspace for the broader shipping sector contributing to GAIA-X by establishing a core European industry resource that accelerates the green and digital transition of waterborne shipping and transport value chains. b. Simulation based solutions to retrofit ships, targeting 55% reduced CO2e reduction by 2030. c. A smart green “new-build” reference design per vessel type. d. Virtual Testbed services for reducing the cost of physical testing of GS solutions by 20%.

Keywords: digital twins,green smart shipping,decarbonisation,shipping dataspace,
Comparative Reconstruction of Ape and Hominin Locomotor ontogeny (CRAHL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-09
End date: 2025-01-08
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Of all the traits that define humans, bipedal locomotion likely evolved first. How and why bipedalism evolved in the fossil human (hominin) lineage are fundamental questions in palaeoanthropology. An underexplored dimension of “how” bipedalism evolved is its growth and development (ontogeny). Humans locomotion develops much slower than those of other apes. Modern humans are also fully terrestrial, while the other African apes transition from predominantly arboreal locomotion using their upper limbs as juveniles to predominantly terrestrial knuckle-walking as adults. The importance of arboreal locomotion throughout hominin evolution has remained debated since the 1980s. However, since all extant apes are most arboreal as juveniles, the answers to this debate are most likely found in juvenile hominins.We know little about hominin locomotor ontogeny and the behaviour of juveniles due to (1) a lack of fossils and (2) limited tools for behavioural reconstruction. CRAHL applies recent methodological advances to both well-studied and newly discovered fossils to overcome these limitations, and will be the first to investigate the evolutionary pattern of hominin locomotor development. Bones can dynamically adapt to changes in loading direction, magnitude, and frequency by altering the structure of trabecular bone, the 3D mesh-like structure found underneath joint surfaces. Trabecular structure can therefore provide a functional record of developmental variation in loading conditions as animals learn to locomote. By using state-of-the-art methods for analysing age-related changes in trabecular bone structure throughout the skeleton, CRAHL will reconstruct how quickly hominins learned to locomote and the variety of postures they assumed, including arboreal versus terrestrial locomotion. By combining state-of-the-art methods new fossil discoveries, CRAHL sheds new light on the evolution of two defining human traits: slow development and fully terrestrial bipedalism.

Keywords: human evolution,locomotion,ontogeny,bone functional adaptation
Isotopic signatures in crystalline carbonates: the role of amorphous precursors (IsotopAmor)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Austria,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-15
End date: 2026-07-14
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: SIGNED

Past environmental conditions (e.g., temperature) cannot be directly measured. However, they are recorded in a measurable way in paleoclimate proxies, which are physical, chemical and biological materials preserved within the geological record in paleoenvironmental archives, and that can be analyzed and correlated with environmental parameters. Carbonates are one of the most important paleoenvironmental archives as they record the formation environmental conditions in their chemical and isotopic composition. However, to use them as paleoenvironmental proxies is essential that the original signatures are preserved. It has been reported that the formation of many carbonates from different geological settings involves the precipitation of amorphous precursors (non-classical nucleation pathways) and their subsequent transformation into crystalline phases. This formation pathway could modify the original signatures restricting the use of carbonates as paleoenvironmental proxies. Yet, the effects on the isotopic composition of carbonate minerals due to phase transitions from amorphous precursors have been largely overlooked compared to the modifications due to diagenetic or depositional processes. Then, the main goal of the project is understanding how different pathways and transformation mechanisms of amorphous precursors control the isotopic composition of the final crystalline polymorph. This aim will be tackled under two approaches abiotic and biogenic conditions and combining mineralogical, microbiological and geochemical tools. The results could generate new guidelines for optimizing paleoclimate reconstructions using ancient carbonate minerals. This project, its impact and outcome, as well as the training in cutting-edge techniques I will get in the host and secondment host laboratories, complementary to my expertise and transferable skills, will transform me in an independent, highly competitive researcher helping me to obtain a stable scientific position.

Keywords: amorphous calcium carbonate,isotope chemistry,biomineralization
Adaptive potential for changes in environmental conditions in exploited fish species. (FishAdapt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Global change is threatening life at the seas by changing the physical, chemical, and biological conditions of the environment. Thus, marine species will need to adapt to the new environmental conditions to thrive. This adaptation depends on the genetic variation within species, as it is the raw material on which natural selection works. Because environmental conditions at the sea are heterogeneous and most marine species are distributed across these diverse marine environments, it is likely that the genetic variation making possible the adaptation to changes in the environment is currently present within populations. Thus, the genetic flow among populations (or environments) can be one of the most important factors enabling adaptation to future environmental conditions in fish. However, harvesting fish populations is likely eroding their capacity to adapt to changes in the environment where they live. Thus, the goal of this study is to quantify the adaptive potential and likelihood of adaptation to environmental change in exploited fish populations, contributing with clear transferable knowledge to fisheries management strategies towards long-term sustainability. To do this we will use neutral and functional genetic variation data of two fish species from different environments presenting different degrees of exploitation. Potentially adaptive genetic variation will be revealed by looking for signals of both, adaptive and balancing selection among environments. Then, we will quantify the amount of potentially adaptive genetic variation and the effect of harvesting on it. Finally, we will investigate the strength of selection to get a likelihood of adaptation to future environmental change. Overall, the expected results of this study will set up theoretical and methodological frameworks for the evaluation of the current levels of adaptive potential for future environmental change in exploited fisheries.

Keywords: adaptive fisheries,evolution,natural selection,climate change,global change,genomics,adaptation,climate change,global change,genetic diversity,balancing selection,
Developing a ground-breaking infection prevention and control (IPC) complaint Transparent Fluid Resistant Surgical Face Mask (TFRSFM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 1380306.0
EU funding (EUR): 1380306.0
Participants: 1
Project status: SIGNED

Contechs Consulting will develop a cost-effective, disruptive, infection prevention and control (IPC) complaint transparent fluid resistant surgical face mask (TFRSFM) to help those who rely on lip reading or other facial visibility requirements- while also ensuring to meet the established EU standards BS EN 14683:2019. Opaque surgical face mask (OSFM) covers user’s mouth, conceal emotions, facial expressions and in turn block the ability to lipread. This makes communication extremely difficult, frustrating for people who are deaf or hard-of hearing, patients/service users with cognitive problems such as dementia, speech, learning or developmental disabilities. OSFM creates anxiety issues and leaves these vulnerable groups more disabled and ostracized. In healthcare sector, OSFM imposes emotional barrier and makes communication challenging between medical professionals and vulnerable patients. Currently available transparent face masks are not appealing to the users due to high cost, discomfort (fogging, sweating), poor quality and standards of the transparent window (TW) and its fragile bond with mask body. Hence, such masks are unreliable to be used in high-risk environments such as hospital and indoor settings. TFRSFM has anti-irritant, anti-glare, anti-fog, anti-fracture TW and adequate layers of adhesive strips between the TW and mask body. TFRSFM has received full approval from NHS England’s Technical Assurance Division, Four Nations Review Panel, and meets the UK governments transparent mask technical specification. It will provide same level of wearer protection and source control to a type IIR OSFM. Hence, it can be used in all healthcare and high-risk settings to boost clear communication and improve patient care and outcomes and ensure adherence to interventions. This project will significantly contribute towards building an inclusive society and improve the health and well-being of those affected by OSFM.

Keywords: fluid resistant transparent face masks,patient care,medical and healthcare settings,indoor settings,source control,wearer protection,inclusion,healthcare system