Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DDG-MRI for cancer detection - A novel medical imaging approach that correlates to FDG-PET without ionising radiation (DDG-MRI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel,France,Denmark,Germany,Italy,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 2991061.25
EU funding (EUR): 2991061.25
Participants: 7
Project status: SIGNED

Positron emission tomography (PET) measurements of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake have been widely used clinically for tumour staging, prognosis, and treatment monitoring, where it can be more sensitive at detecting treatment response than magnetic resonance imaging (MRI) and computerised tomography (CT) -based evaluations of tumour size. 2-deoxy-D-glucose (DG) and FDG are non-metabolisable derivatives of D-glucose that get trapped in the cells of active or malignant tissues. Even though highly sensitive, the ionising radiation associated with FDG-PET limits its frequent application (typically not more than 2-3 examinations per year) and its use in populations such as children and pregnant women, who may otherwise benefit from this valuable and unique diagnostic imaging examination. As such, alternative techniques are highly demanded. The DDG-MRI project aims at providing the benefits of FDG-PET without ionising radiation. We propose an MRI-based imaging agent and technique that will provide PET-like images with MRI without ionising radiation. To this end, we will make use of 1) a novel DG analogue that is uniformly labelled with deuterons ([D8]2-deoxy-D-glucose) and 2) rapid and sensitive deuterium MRI schemes targeted at demonstrating the uptake of this agent in malignant tissues further to intravenous administration. The expected spatial resolution will exceed that of FDG-PET (~2-3 mm in plane) in a scan time of about 2 min, with a clinically acceptable and commercially relevant dose of the labelled compound. DDG-MRI is likely to be quickly adopted by medical centres as it does not require significant hardware changes, does not change the MRI suite workflow, and is expected to cost the same as a PET scan. This consortium comprises six partners (two from industry) from five countries, enthusiastic about making DDG-MRI a medical reality for cancer detection and treatment monitoring.

Keywords: deuterium,2 deoxy d glucose,magnetic resonance imaging,positron emission tomography,stable isotope chemistry,cancer diagnosis
WIDEn performance in research and innovation capacity and competence Across EU (WIDE AcrossEU)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Economic Sciences
Countries involved: Czechia,North Macedonia,Ukraine,Finland,Sweden
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-05-01
End date: 2027-08-31
Duration (months): 40.0
Total project cost (EUR): 1200000.0
EU funding (EUR): 1200000.0
Participants: 5
Project status: SIGNED

Our consortium consisting of partner institutions from Czechia, North Macedonia, Ukraine, Finland and Sweden have diverse experience with participation in Horizon Europe (HE), Synergic EU R&I funding, Smart Specialisation Clusters and other international R&I funding schemes, consider this call as the opportunity to strengthen institutions from Widening countries and upscale them on higher level through capacity, skills and competence building and networking actions. The key objective of the project “WIDE AcrossEU” is to move us, participants from Widening countries (the core group - 3 higher education institutions from the Czech Republic, North Macedonia and Ukraine), who are formerly a current single beneficiaries of regional funding programmes (ERDF, IPA, Interreg and similar investments for R&I infrastructure), to higher level and prepare us for wider and more successful participation in direct EU funding programmes. The specific objectives, which are: 1. To map the needs and requirements of target groups in Widening partners - State of Play, 2. To strengthen competitiveness of target groups in Widening countries by acquiring new transferable skills for R&I staff, 3. Access to networks and partnerships to secure more successful proposal and create a base for lead partner roles for Widening partners, 4. To better use R&I infrastructure funded under ERDF or similar investments, 5. To create strategies for R&I and Human Resources, 6. To improve access to excellent European R&I networks and communities, will be achieved through following work packages: WP1 Need of analysis for capacity and competence building, WP2 Acquisition of new transferable skills, WP3 Exploitation of R&I funding opportunities & networks, WP4 R&I valorisation, policy support and synergies, WP5 Dissemination, communication and exploitation, WP6 Management and coordination. The project will last 40 months.

Keywords: randi funding,randi infrastructure,transferable skills,networking,human resources strategy,randi internationalisation strategy,regional authorities,national authorities,industry,universities
A comparative analysis of school-aged refugees in educational settings (SCHOOLAGEES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Estonia
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 205745.52
EU funding (EUR): 205745.52
Participants: 1
Project status: SIGNED

The number of refugees seeking asylum in Europe has increased significantly in recent years, giving rise to questions about the efficacy of the measures put in place to facilitate their integration in the receiving countries. Schools occupy a pivotal position in the process of refugee integration, representing the initial social environment in which school-aged refugees are integrated following their arrival. The introduction of a framework of S-connections (School-Spare time-Society) in the SCHOOLAGEES project addresses a critical research question that has been overlooked in previous studies: namely, how does children’s engagement in educational settings in the host country facilitate their parents’ social integration? The research will adopt a policy-oriented socio-anthropological approach and employ an innovative methodology of qualitative content analysis of social media groups of parents. This will enable an exploration of the informal patterns and hidden mechanisms through which parents are involved in socialisation processes in the school context and interact with other parents. The research will demonstrate the significance of the informal school network and illustrate its capacity to assist educational institutions in advancing the social integration of school-aged refugees and their families. The objective is to establish a comparative framework of good practices implemented in Estonia and Italy, with a view to disseminating it to relevant stakeholders and to other countries that may benefit from its insights. This objective will be achieved through the implementation of research initiatives with specific focus on groups of Ukrainian refugees in Estonia and Palestinians in Italy.

Keywords: educational settings,comparative analysis,informal networks
Prompt Gamma Time Imaging: a new medical-imaging modality for adaptive Particle Therapy (PGTI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France,Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2028-09-30
Duration (months): 72.0
Total project cost (EUR): 1498969.0
EU funding (EUR): 1498969.0
Participants: 3
Project status: SIGNED

Particle Therapy (PT) is potentially the most conformal and selective form of radiotherapy, but its clinical outcome is still limited, mainly because of the numerous sources of uncertainties affecting both treatment planning and delivery. The objective technical complexity of predicting and verifying the ion path in the patient has led to conservative treatments that, in order to increase safety, sacrifice efficacy. Having the full control of the dose gradient within the patient in real time would allow to fully exploit the ballistic advantage of PT. The healthy-tissue sparing effect can be enormous, further encouraging the use of PT for paediatric malignancies. Alternatively, the target dose could be increased to achieve better tumour control, and dose escalation procedures could be envisaged to treat radio-resistant tumours. With the aim of increasing both safety and efficacy, I propose a new medical-imaging modality to monitor PT treatments in real-time. It exploits the signal of secondary prompt gamma-rays emitted from nuclear interactions in the patients to recover information on ion range, tissue density and dose. I refer to this technique as Prompt Gamma Time Imaging (PGTI). An original reconstruction algorithm and a dedicated detector will be developed to prove the clinical advantages of PGTI, and bring this technique at the doorsteps of its clinical application. I will develop models to correlate the images provided by PGTI to real-time dose distributions, in order to enable the use of this technique for adaptive dosimetry. PGTI will be also explored as a potential approach to proton tomography. For the first time, it would be possible to control the uncertainties affecting both treatment planning and treatment delivery with a unique device. PGTI may be the missing step towards the birth of image-guided particle therapy.

Keywords: gamma ray detection
Carbon Neutral Milk (CANMILK)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 382740.25
EU funding (EUR): 382740.25
Participants: 2
Project status: SIGNED

Carbon Neutral Milk project (CANMILK, grant number 101069491) focuses on methane abatement in dairy production. The aim is to decompose methane in dairy barns by applying non-thermal plasma based technology. The same technology can be applied also in meat production, for example in piggeries. In this proposal, the addition of University of Lisbon to the CANMILK project is applied to strengthen the scientific understanding of the studied phenomenon. The novelty of the on-going project is to combine plasma technology and catalysis to develop an energy efficient method for the abatement of highly dilute methane, i.e. methane that is found in the concentrations significantly below 1 vol% in the indoor air of animal barns. In the on-going project, the topics of catalysis and plasma are individually well-covered with the current work plan. However, the remaining key question is what happens on the direct interface of plasma and catalyst? To study this topic, University of Lisbon proposes to utilize both their modelling and experimental expertise. Significant scientific and techno-economic value is brought by increased understanding of the phenomenon on the plasma-catalyst interface. The activity and lifetime of the plasma-generated radicals on the catalyst surface has direct impact on the feasibility of the developed technology. The catalyst performance can be increased thermally, but any additional heating would deteriorate the energy efficiency of the process. Therefore, the understanding of the radical transfer from plasma to the catalyst would greatly improve the design of the CANMILK technology.

Keywords: environmental engineering,methane abatement,plasma,catalysts,agriculture,enteric methane,dairy industry
Deciphering the Exposome by Metabolomic Technology in Breast Cancer (EXPOMET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2937489.0
EU funding (EUR): 2937489.0
Participants: 1
Project status: SIGNED

EXPOMET proposes a pioneering mass spectrometry-based platform for omic-scale assessment of chemical exposures. EXPOMET will revolutionize our perception of environmental contaminants and the influence these have on breast cancer (BC). In our ageing society, the incidence of chronic disease is constantly rising; yet, environmental drivers of disease susceptibility are poorly understood. Measuring the myriad of chemicals that humans are constantly exposed to is immensely challenging; and identifying interactions and the molecular pathways that are disrupted is an even more complex task. To address this issue, the concept of the exposome, i.e., the totality of chemical exposures and the biological effects thereof, was proposed. Innovative analytical technology, however, is lacking and remains the major limitation in this emerging field. EXPOMET aims to establish new avenues towards a comprehensive sequencing of the exposome and illuminating the role played in the etiology of BC. Affecting 1 in 8, BC is the most common cancer in European women. Novel workflows will overcome current limitations and enable high-throughput exposure and effect monitoring of a vast number of environmentally-relevant chemicals. The developed cutting-edge methods will be applied, and critically evaluated, in the first exposome-wide association (ExWAS) study on BC. A deeper understanding of the toxicological impact of co-exposure will be obtained from ensuing functional, systems-level experiments. Breakthrough metabolomic-guided pathway mapping and activity-screening technology will be utilized for investigating causative events. The project will provide unique insights into the impact of chemical exposure on the etiology of BC and ground-breaking exposomic technology. EXPOMET will revolutionize viewpoints on environmental contaminants and the influence these have on chronic disease. The PI has a uniquely interdisciplinary expertise to address the multi-facets of this exposome approach.

Keywords: exposome,metabolomics,food safety,food contaminants,mass spectrometry
Logic in Reverse Redux. Illegitimate Argumentative Moves in the Arabic, Byzantine, Hebrew and Latin Medieval Traditions (RevLogRedux)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,Switzerland,United Kingdom,Italy,Sweden,Canada
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-05-01
End date: 2031-04-30
Duration (months): 72.0
Total project cost (EUR): 9972686.26
EU funding (EUR): 9972686.26
Participants: 7
Project status: SIGNED

Bad arguments have never been in short supply. The same holds for the scholarly interest they have elicited both in their own right and as a cautionary tale about everything that can go amiss when we argue. This is hardly surprising. Asking what is wrong with flawed arguments is tantamount to investigating the very rules and principles of argumentation – only in reverse. Fallacy Studies have flourished in recent years (especially under the label of «critical thinking»). Without notable exception, the ever-growing literature on argumentative failures suffers from a conspicuous lack of interest in medieval fallacy theory – arguably one of the most creative stages in the whole history of argumentation theories. The standard story is that after Aristotle got off to a tentative start, the study of fallacies lay dormant until people at Port Royal and John Locke revived it. RevLog Redux will show that this narrative is misleading and will replace it with a new account which will bring to bear the full resources of medieval treatments of illegitimate argumentative moves within and across the Latin West and the Greek East, as well as in the Arabic and the Hebrew traditions. In an unprecedented attempt to explore how medieval authors discussed fallacies, RevLog Redux will lay the groundwork for more conscious and historically sound ways to describe, classify and theoretically assess the laws and flaws of argumentation. To that end, RevLog Redux will develop an integrated computational infrastructure to manage the wealth and complexity of data, information and knowledge the project is expected to produce: namely, AskSten (as in «Ask Sten Ebbesen»), a multi-layered virtual research environment whose digital archive, knowledge base, Semantic Web architecture and on-line deployment will dramatically enhance the formal expressivness and coherence of the project’s findings. AskSten will also include a curated open access Encyclopaedia of Illegitimate Argumentative Moves.

Keywords: medieval philosophy,history and analysis of logic and argumentation,cross cultural medieval intellectual history
The roadmap enabling spinal cord regeneration in mammals (CORDheal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499963.0
EU funding (EUR): 2499963.0
Participants: 1
Project status: SIGNED

It is widely documented that the adult mammalian central nervous system (CNS) does not regenerate. This failure results from the inhibitory scar environment and the decline of developmental growth programs. Overturning this dogma, the PI recently demonstrated that the spiny mouse (Acomys cahirinus) regenerates spontaneously the spinal cord, with robust functional recovery. Her current preliminary data support that an early switch occurs in the injured Acomys spinal cord, allowing scar reversion and activation of a regenerative program. In CORDheal, this exceptional non-model organism will be used to address the knowledge gap on the mechanisms enabling a mammal to regenerate the CNS. The pioneering nature of the PI’s data and her unique combined expertise in CNS regeneration and Acomys biology, places the PI at the forefront of the field. To find the roadmap enabling spinal cord regeneration in mammals, a single cell RNAseq/ATACseq atlas of the injured spinal cord of Acomys and Mus (regeneration-incompetent mouse) will allow discovering cell populations that enable activation of pathways supporting scar avoidance and promoting regeneration. The extent to which regeneration recapitulates development, and the possible birth of novel genes that may contribute to adaptive evolutionary innovation will be tested. As major instructive programs that allow regeneration of different Acomys tissues may be similar, comparative analyses amongst different regenerating Acomys organs will follow. Lastly, to determine when regenerative ability evolved in mammals, other members of the Deomyinae subfamily (to which Acomys belongs) will be assessed for regenerative properties. This will allow finding putative close divergent species, providing ideal conditions to narrow down differences between regeneration and scarring. This ambitious and pioneering program will push current research boundaries to unveil vital cell adaptive mechanisms underlying regeneration in mammals.

Keywords: spinal cord injury tissue regeneration mammalian cns non model organism
Risk and Resilience in Developmental Diversity and Mental Health- HOP ON (R2D2-MH- HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Estonia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

Neurodevelopmental disorders (NDDs) affect 10-15% of the population, typically manifesting in childhood but often persisting throughout life, impacting mental, cardiovascular, metabolic, and endocrine health. Research on the mechanisms of NDDs has predominantly focused on clinical pediatric cohorts with NDDs, such as autism, attention deficit hyperactivity disorder and intellectual disabilities. However, NDD features, such as inattention or impulsivity/hyperactivity, are also common in adults, but often remain unnoticed and unmanaged, leading to significant health and social consequences. Our current understanding of the genetic and environmental risk and resilience factors underlying NDD features in adulthood, as well as their long-term mental and somatic health consequences remains limited. R2D2-MH-HopOn aims to address the gaps in our knowledge about mental health risk and resilience factors linked to NDD features in adults (age 18 and above) by integrating the University of Tartu(UTARTU), Estonia, into the EU-funded R2D2-MH project. Utilizing the Estonian Biobank, one of the largest population biobanks in the world, UTARTU will perform tasks on genetic and non-genetic risk and resilience factors for NDD traits across the adult lifespan, expanding the original R2D2-MH goal of improving the mental health outcomes across the lifespan for young NDD individuals. At the same time, UTARTU will: 1) gain experience in co-creation with stakeholders; 2) get exposed to new knowledge such as predictive machine learning modeling, brain organoid and imaging research; 3) improve connections between data scientists and clinicians; 4) establish connections with the leading institutions from the R2D2-MH consortium; 5) enhance its international profile and visibility. R2D2-MH-HopOn will further strengthen participatory research and reduce the stigma associated with mental health issues thanks to the involvement of neurodiverse representatives from Estonia in project activities.

Keywords: neurodevelopmental disorders,adhd,gwas,cnvs,biobank,electronic health records,pgs