Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Illuminating human Fe-S cluster biology (FeSurveil)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Iron-sulfur (Fe-S) clusters were ancient partners in the origin of life- spontaneously formed in the anaerobic primordial oceans, they likely helped catalyze carbon fixation and rudimentary metabolism. Highly versatile, Fe-S clusters unlock previously inaccessible abilities for their binding proteins, aiding in electron relay, catalysis, regulation, and structural stability. Over the past 20 years, it has become clear that Fe-S clusters must be formed de-novo within the cell by essential proteinaceous machineries and relayed directly to their binding proteins. During this time, huge strides have been made to delineate the components and molecular mechanisms of this pathway. However, our grasp of the regulation, client range and dynamics of Fe-S cluster biosynthesis in the human cell remains fragmented. These critical gaps of knowledge hinder our understanding of how Fe-S cluster biosynthesis supports healthy human cells and how its breakdown can lead to multiple diseases. We aim to break through to a new level understanding of human Fe-S cluster biosynthesis– catapulting our knowledge forward to encompass its holistic cellular state. In FeSurveil, we will broadly and unbiasedly identify the human Fe-S cluster proteome (Aim 1), uncover regulators of Fe-S cluster biosynthesis (Aim 2), and dissect client priorities for the relay proteins (Aim 3). FeSurveil will leverage our expertise in Fe-S cluster biology and capitalize on our unique interdisciplinary skills, spanning tool creation, state-of-the-art genetic profiling, proteomic analysis, cell biology and biochemical approaches. Together, these independent but synergistic lines of research will illuminate the complex reciprocal relationship between Fe-S cluster biosynthesis and the dynamic cellular environment. This comprehensive perspective is essential for understanding fundamental aspects of human Fe-S cluster biology, while also providing valuable information for disease intervention and bioengineering.

Keywords: fe s clusters iron co factors fe s cluster biosynthesis friedreich s ataxia
NEutRally buoyant ParticlEs In the DEep Sea: turnover, origin and global impact on the marine carbon cycle (NEREIDES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2841791.0
EU funding (EUR): 2841791.0
Participants: 1
Project status: SIGNED

Export of organic matter produced in the sunlit surface waters into the ocean’s interior removes about one third of the anthropogenically produced carbon dioxide. The amount of organic matter sinking into the deep ocean, however, is not sufficient to support the carbon demand of the heterotrophic food web in the ocean’s interior as revealed by several studies. Consequently, the oceanic carbon budget cannot be closed. Recently, we identified a hitherto unrecognised non-sinking, non-living particulate organic matter (POM) pool in the dark ocean with rather stable concentrations throughout the water column. This particle pool has not yet been considered in the deep-sea carbon budgets. Its origin and fate remain enigmatic as well as its nutritional role for the deep-sea biota. We aim at deciphering the compositional differences between the sinking and non-sinking detrital POM and compare their properties with that of the dissolved organic matter using state-of-the-art methods including proteomics. Specific focus will also be put on the composition and activity of the particle-associated biota in the ocean’s interior. We will analyse, for the first time ever, the composition of the biota and the biogeochemistry of these two classes of detrital particles in the deep North Atlantic. The results of NEREIDES will help elucidating the origin and fate of these enigmatic suspended particles and allow testing a major unresolved aspect in deep-sea biogeochemistry, i.e., whether these suspended particles provide the missing carbon to resolve the current mismatch in our measurements between organic carbon supply and demand of the heterotrophic deep-sea biota. The obtained results will form the base to model the dynamics of the non-sinking particles in the ocean on a global scale. Thus, NEREIDES will fill a major knowledge gap in the oceanic carbon cycling.

Keywords: oceanic carbon cycling,marine snow,biological carbon pump
Acoustic Reflection Imaging for Electrochemical Systems (ARIES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Lithium-ion batteries are crucial for the global energy transition, powering everything from electric vehicles to renewable energy storage systems. However, the battery manufacturing industry faces significant challenges, including inefficiencies, high scrap rates, and costly recalls, which undermine the production process and sustainability efforts. Sention is a technology company from the United Kingdom with a vision to address these issues and develop breakthrough measurement solutions for electrochemical power. We are pioneering a novel approach to “see inside” lithium-ion batteries through the use of acoustic measurement techniques. As a result, we are able to rapidly assess the quality of cells and identify failures, thus giving unparalleled insights that traditional methods fail to achieve. Our technology will revolutionize the battery industry with breakthrough measurement solutions that enhance safety, reliability, and efficiency, ultimately supporting the global energy transition.

Keywords: electrochemical systems measurement,battery diagnostics,acoustic measurement
Quantum-oriented Update to Browsers and Infrastructures for the PQ Transition (QUBIP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Italy,Spain,Finland,Czechia,Germany
Call: Transition towards Quantum-Resistant Cryptography (HORIZON-CL3-2022-CS-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 5600100.0
EU funding (EUR): 4999648.0
Participants: 15
Project status: SIGNED

The exciting frontiers opened by the development of quantum computers (QC) come at the cost of breaking the foundations of current digital security. The research community is working to the definition of post-quantum cryptography (PQC) to counteract this threat. However, the transition to PQC is delicate and takes time because it impacts many functions, algorithms, and protocols in a-priori unknown cascade of dependencies. QUBIP is conceived to contribute to the EU transition to PQC with the goal of simplifying and making replicable the process by means of recommended practices and counteract post-quantum threats as soon as possible. QUBIP focuses on digital infrastructure addressing the 5 main building blocks that use public-key cryptography for security purposes: hardware, cryptographic libraries, operating system, communication protocols and applications. QUBIP address all 5 blocks coherently solving all dependency issues that may arise inside each block and among blocks with the final aim to validate at TRL6 three infrastructures making use of those blocks in IoT-based Digital Manufacturing, Internet Browsing, and Software Networks Environments for Telcos use cases. The return-of-experience from the three practical exercises is then maximized by developing a migration playbook, that will contain the lessons learned and an evaluation of all the technical, economic, and legal barriers encountered together with the solutions to overcome them to enable the definition of a replicable process, suitable to provide structured accompanying and practical guidance to industrial stakeholders. The technical activities are corroborated by three supporting activities (i) evaluation of the capabilities of QCs to assess their implication to primitives, algorithms and protocols adopted, and contribution to (ii) standardization efforts addressing transition to PQC processes and (iii) policy measures addressing technology changes coming from the advent of QC and PQC.

Keywords: cryptographic agility pqc transition digital manufacturing internet browsing software networks environments
Mainstreaming Integrated Assessment Models by embedding behavioural change and actor heterogeneity, and increasing their outreach to citizens, communities and industrial actors (CHOICE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Greece,Austria,France,Serbia,Spain,Colombia,South Africa
Call: Improvement of Integrated Assessment Models in support of climate policies (HORIZON-CL5-2022-D1-02, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 4936472.51
EU funding (EUR): 4936472.5
Participants: 16
Project status: SIGNED

The Integrated Assessment Models (IAMs) are an invaluable instrument for modelling climate stabilization pathways and for supporting the policy makers in taking better informed decisions. Nevertheless, the mitigation options traditionally focused on in IAMs are the supply-side measures, whereas less attention used to be paid to demand-side and food system representation, due to the inherent complexity and actor heterogeneity. CHOICE aspires to mainstream IAMs, embedding them into the lifestyle choices and decision making process of consumers, producers and actors of the Food, Agriculture and Land Use sectors. This ambition is leveraged by a more realistic representation of behaviour change and actor heterogeneity aspects in IAMs, and supported by an approach that bridges social science and marketing tools, with the aim of accelerating climate action. This approach will be supported by the large-scale adoption of CHOICE digital immersive tools, data storytelling and gamification, whose design is underpinned by notions of emotional appeals and social incentives. Using these digital enablers, CHOICE will orchestrate large scale engagement and ‘green marketing’ campaigns, that have a wide geographical and societal dispersity. Thus, starting from a bottom-up analysis of individual consumers and actors of the food supply chain, and understanding their behavior and their potential for change, CHOICE will use this information in order to consistently feed into a new generation of IAM models, that will correctly reflect the underlying heterogeneity, accounting for multiple representative consumers and actors. The IAM-generated impacts from highly influential 1.5oC-compatible mitigation actions shall highlight, besides emissions, the co-benefits of their changes in behaviour or practice in terms of health, biodiversity and food security aspects, in familiar scales.

Keywords: integrated assessment models,demand side measures,behavioural change,transparency,usability,engagement campaigns,digital immersive tools,food,agriculture,land use
TOLWEC: Fault diagnosis and fault-tolerant control for reliable wave energy converters (TOLWEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Denmark,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-12-31
Duration (months): 30.0
Total project cost (EUR): 335710.8
EU funding (EUR): 335710.8
Participants: 3
Project status: SIGNED

The EU aims to raise the European share of renewables from 23% in 2023 to 42.5% by 2030. Such a goal implies obtaining clean energy from diverse sources. Although sea waves can provide a massive contribution in this sense, the commercial use and development of wave energy converters (WECs) are still very limited. This fact has been attributed to expensive production, installation, and maintenance, caused by the hostility of the sea environment and the corrosive nature of seawater. To achieve an appropriate balance between reliable performance and economic costs of WECs, the main objective of the TOLWEC project is to build a framework for fault diagnosis (FD) and fault-tolerant control (FTC) based on a multilevel scheme, composed of local fault handling (i.e., FD and FTC) of each subsystem of the WEC, coordinated by a higher-level fault handling for the whole WEC. The main subsystems of a WEC are (i) a primary converter (PC) that captures mechanical energy from the waves, (ii) a power take-off (PTO) that converts mechanical energy into “raw” electric energy, and (iii) an electric power converter (EPC) that makes electric energy fit for consumption. Each subsystem has sensors and actuators for the diagnosis and control tasks. The sensors measure dynamic variables of the system, while the actuators allow one to shape the behavior of the system. The proposed research requires obtaining high-fidelity models of each subsystem, modelling possible faults, assessing the availability and cost of sensors and actuators, and designing the local and global FD and FTC schemes. As a result, the proposal will increase the economic viability of WECs by (i) reducing operational costs with accurate and early FD to avoid expensive repairs, (ii) preserving the energy conversion in the presence of faults with a multilevel FTC scheme, and (iii) avoiding a substantial increase of the installation cost by establishing the priority of redundant sensors and actuators in the system.

Keywords: wave energy converters fault tolerant control fault diagnosis
Spin based quantum computer and simulator (SPINUS) (SPINUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Belgium,Sweden,Netherlands,Hungary,Italy,Czechia
Call: Investing in alternative quantum computation and simulation platform technologies (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 10166376.25
EU funding (EUR): 10166376.25
Participants: 12
Project status: SIGNED

The SPINUS project aims to establish experimental platforms for both quantum simulation (with >50 quantum units) and quantum computation (with >10 qubits). Despite rapid advancements, scaling and implementing quantum simulators and computers towards a regime surpassing available classical methods remains difficult due to the demanding constraints of existing architectures. By utilizing the exceptional qualities of silicon carbide (SiC) and diamond materials, the SPINUS project suggests a novel strategy for scalable solid-state quantum simulation and computation hardware based on nuclear spin networks and dipole-dipole entangled electron spin qubits. Our first goal is to create a quantum simulation platform that uses optically polarized NV centers and color centers along with nuclear spin networks in diamond or SiC. This technology allows for the investigation of a wide range of strongly correlated models without being constrained by the capabilities of the available quantum simulators. Second, we aim at scaling up platforms for solid-state quantum computing to more than 10 fully programmable qubits at ambient temperatures. For these purposes, the consortium will investigate various architectures and techniques for initializing, controlling, and reading out the spin qubits with the goal of achieving large-scale quantum simulation and computation capabilities. This will take advantage of the excellent coherence properties and robustness against environmental noise of these materials. SPINUS has great potential to advance the field of quantum computing and simulation and open new possibilities for the investigation of intricate quantum systems by fostering and contributing to a European quantum and a European diamond ecosystem by working closely with start-up businesses affiliated with the project team and cooperation with the related Flagship initiatives.

Keywords: quantum computing,quantum simulation,nv centers in diamond,color centers in sic
Resolving sEx DIffeREnces in proCessing sensory informaTion (REDIRECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1999138.0
EU funding (EUR): 1999138.0
Participants: 1
Project status: SIGNED

Mental disorders are associated with abnormal sensory information processing (SIP) at preadolescence, especially in males. Aberrant SIP is a neutral cross-disorder trait that can be translated between humans and animals and assessed as the inability to prevent/gate an overload of irrelevant information. The mechanisms underlying physiological and pathological SIP variability are unexplored. Particularly, the causative role of hyperdopaminergia, key to SIP deficits, has never been tested by isolating, spatially and temporally, this single neural component. How does this trait evolve into a mental disorder? Why does it occur more often in males? REDIRECT will capitalize on our rodent model of prenatal cannabis exposure (PCE), which is the first of its kind to offer, at preadolescence, a sex bias in susceptibility to SIP deficits upon acute exposure to stress or cannabis. This animal model is amenable to molecular interrogation to probe causality for those resilience-promoting factors preventing females from developing a hyperdopaminergia and SIP deficits. By combining viral strategies to trace and probe cell-type specific input-output reorganization of dopamine circuits (Aim 1), with single-cell transcriptome analyses (Aim 2), REDIRECT will decipher how female sex imposes distinct molecular changes to neurons and circuits, which are key to prevent the etiopathogenesis of SIP disorders. By testing selected candidate genes to probe causality for how sex modulates genes, developmental trajectories, and behaviour, we will decode (Aim 3) how discrete dopaminergic circuits can be reprogrammed sex-dependently. REDIRECT will causally disentangle how sex differently affects genes, circuits, and behaviour to inform novel sex-specific and age-tailored therapies for SIP deficits, a cross-disorder trait typical of common and severe mental illnesses, including autism, attention deficit hyperactivity disorder, obsessive-compulsive disorder and schizophrenia
Ultimative Photovoltaics (UltiMatePV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Switzerland,France
Call: ERC SYNERGY GRANTS (ERC-2025-SyG, 2025)
Start date: 2026-02-01
End date: 2032-01-31
Duration (months): 72.0
Total project cost (EUR): 9985893.0
EU funding (EUR): 9985893.0
Participants: 3
Project status: SIGNED

The transition towards a society powered by 100% renewable energy necessitates the widespread de-ployment of photovoltaics. This poses a challenge due to the limited availability of resources and space. To address this, breakthrough technologies that consume fewer resources and achieve higher conversion efficiencies than the dominant silicon technology are required. The overarching goal of UltiMatePV is to re-invent the modern solar cell and open the gate to a new generation of resource-saving photovoltaic technology with highest conversion efficiencies. Enabling light-trapping beyond the Lambertian limit, based on schemes such as multi-resonant photonics, will allow for the realiza-tion of higher efficiency solar cells with typically 10x less use of semiconductor materials and thus reduce the required resources tremendously. This strongly reduced device thickness will also lead to confinement of the photo-generated charge carriers. The resulting increase of the carrier concentration will open the door for the realization of the worldwide first efficient hot-carrier cell, in which most of the carriers can be extracted before they thermalize. A new generation of devices based on the three currently relevant types of semiconductor absorbers (Si, III-V, perovskite) will be researched, account-ing for, e.g., the new requirements in terms of compatibility with resonant optical structures and ultra-low interface defect density. The unique complementary consortium of experimental, theoretical and modelling teams will overcome the Shockley Queisser limit for single junction solar cells with both ultrathin multi-junction and hot-carrier solar cells, enabling the first experimental proof of effects pre-dicted theoretically. We aim for a solar cell with an efficiency of 40%, requiring 10 times less semi-conductor material than classical devices, while paving the way to a broader range of other optoelec-tronic devices.

Keywords: photovoltaics,ultrathin photonics,perovskite,hot carrier