Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart Pressure Vessel for water desalination with reverse osmosis membranes (SmartDesalt)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain,Israel
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The United Nations predicts that by 2025 two-thirds of the world's population will suffer water shortages, especially in the developing world and the parched Middle East. In Europe, water is also a major concern in countries that fall under the Mediterranean basin such as Spain, Italy, Turkey, Greece, France and Israel. Fresh water is required not only for drinking and domestic purposes. Industry accounts for nearly 60% of fresh water withdrawals in the developed world and agriculture consumes 70% of fresh water supplies globally. Consequently, an adequate supply of good-quality water is a pre-requisite for economic and social progress, and competition for water poses a growing risk to the economy, communities and the ecosystems they rely on. The growing need for water in the world will be met in a large part by desalination. Governments and industries no longer look to desalination as a secondary, but as a primary alternative to increase water supply for domestic, agriculture and industrial use in the world, and especially in the Mediterranean basin and the Middle-East, the target locations for SmartDesalt. Among desalination technologies, reverse osmosis based desalination is the most popular because it is the most energy efficient. However, costs are still the largest barrier for its implementation. ROTEC, an innovator in commercializing technology to prevent scaling in membranes and pipes, has joined forces with BEL Composite Ibérica, world-leader in pressure vessels (membrane housing) for water desalination systems, to exploit a joint business opportunity. They will develop a new generation of smart pressure vessels which allow the direct on line measurement in real time of the process flow inside the vessel. This allows the detection and identification of early stages of fouling formation (by type, biofouling or mineral scaling, and location on the membrane surface) so that a preventive maintenance strategy can be more efficiently implemented. Such a stra

Keywords: water desalination,fresh water supply,water scaling,ultrasounds
Methodological developments for time-resolved single particle cryo-EM (Ti-EM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 1777157.0
EU funding (EUR): 1777157.0
Participants: 1
Project status: CLOSED

Protein synthesis and degradation, energy metabolism, signalling, processing of information-encoding polymers (RNA and DNA) are facilitated and regulated by molecular machines, protein complexes that undergo significant conformational changes in time as they facilitate their function. To be able to control the biological processes rationally and with high precision it is essential to understand their mechanism at atomic level. A powerful way to gain detailed insight onto function of these proteins is to see these molecules at atomic resolution while they function. The high-resolution structures of biological macromolecules obtained by X-ray crystallography, NMR and more recently single particle electron cryogenic microscopy (cryo-EM) have provided insights onto the way many molecular machines are constructed. These methods generally provide snapshots of discrete long-lived states, visualizing the conformational changes along the reaction trajectory at high-resolution often remains an elusive objective. The aim of my proposal is to develop methods for visualizing transient conformations of protein complexes by time-resolved single particle cryo-EM. Time-resolved cryo-EM combines structural study with kinetics by freeze-trapping kinetic intermediates in a biological reaction and has potential to provide atomic-resolution ‘movies’ of functioning biological complexes. Technical limitations however so far restricted widespread use and utilization of the complete potential of this technique. Main part of this project is dedicated to development of microfluidic instruments for cryo-EM sample preparation. If successful, our approaches will allow trapping kinetic intermediates of molecular machines with millisecond time-resolution using picogram amounts of protein sample. The developed method will be applied to resolve key functional conformations of respiratory complex I and observe regulatory trajectories of ligand-gated ion channels.

Keywords: kinetics,molecular machines,time resolved,image processing
Homeostatic Plasticity beyond the critical period (HOPLA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1499698.0
EU funding (EUR): 1499698.0
Participants: 1
Project status: SIGNED

Fine-tuning of our sensory systems, learning, memory and cognition rely on neuroplasticity, the capability of our brain to change in response to environmental pressures. Neuroplasticity is maximal during development, underlying the peak of our ability to learn in early childhood and also allowing us to adapt to the external world. As we age, the plastic potential of the brain decreases, especially for sensory cortices. The classical view is that the sensory brain becomes hard-wired after the temporal window of maximal plasticity called critical period (6-7 years in humans). As a consequence, the ability of our sensory brain to react to injury, sensory loss and to recover from conditions established during development becomes limited in adulthood. In my previous research I have shown that a particular form of neuroplasticity called homeostatic plasticity is relatively preserved beyond the critical period, opening new horizons on adult sensory plasticity. Building on these observations, in project HOPLA I will unravel the multifaceted nature of sensory neuroplasticity in adult humans, elucidate the underlying mechanisms and explore new forms of plasticity. The project is articulated around four unresolved issues: 1- What is the relationship between Hebbian and homeostatic plasticity? 2- What is the role of excitation/inhibition balance in enhancing and consolidating homeostatic plasticity? 3- Is it possible to elicit new forms of visual and auditory homeostatic plasticity? 4- What is the interplay between neuroplasticity occurring between and within sensory modalities? To address these questions, I will combine classic behavioural measurements of visual and auditory perception with state-of-the-art neuroimaging techniques and virtual reality environments both in healthy and clinical populations (amblyopic and deaf adults). The proposed research is based on strong theoretical hypotheses and has outstanding applications for neuro-rehabilitation in adult humans.

Keywords: visual perception,binocular rivalry,neuroplasticity,psychophysics,magneti resonance spectroscopy,amblyopia,deafness
In-Network Programmability for next-generation personal cloUd service supporT (INPUT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Spain,Italy,Greece,Greece
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3108001.0
EU funding (EUR): 3108001.0
Participants: 9
Project status: CLOSED

The INPUT Project aims at designing a novel infrastructure and paradigm to support Future Internet personal cloud services in a more scalable and sustainable way and with innovative added-value capabilities. The INPUT technologies will enable next-generation cloud applications to go beyond classical service models, and even to replace physical Smart Devices, usually placed in users’ homes (e.g., set-top-boxes, etc.) or deployed around for monitoring purposes (e.g., sensors), with their virtual images, providing them to users “as a Service.” Virtual and physical SDs will be made available to users at any time and at any place by means of virtual cloud-powered Personal Networks, which will constitute an underlying service model. These Personal Networks will provide users the perception to be always in their home LAN with their own smart digital (virtual and physical) devices. The INPUT project will overcome current limitations in the cloud service design due to the underlying obsolete network paradigms and technologies, by: • using the computing and storage capabilities of network appliances to allow users create private clouds “in the network”; • exploiting the energy consumed in network appliances more efficiently than in traditional cloud computing scenarios; • moving cloud services much closer to end-users and smart-devices, thus avoiding useless network infrastructure overloading; The INPUT Project will foster future-proof Internet infrastructures that will be “smarter,” fully virtualized, power vs. performance optimised, and vertically integrated with cloud computing, with a clear impact on OPEX and CAPEX of Telecoms, of Service Providers, and of end-users. The INPUT project will extend the programmability of network devices to make them able to host cloud service applications, which will cooperate with the ones in users’ terminals and datacenters to realize the aforementioned cloud services.

Keywords: personal cloud service,device virtual image,in network programmability,smart infrastructures,consolidation and orchestration,southbound and northbound interfaces,virtualization
Characterization of the Human Gallbladder Microbiome (GallBiome)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

The human gastrointestinal tract harbors a complex community of microorganisms that confer metabolic, immunological and neurological benefits to the host. This assemblage is known as the Gut Microbiome and has received increased attention over the last decade. Scientists have begun to uncover the importance of these bacterial inhabitants and expand investigations to consider how site-specific microbiomes affect host physiology. While more than one million cholecystectomies (gallbladder removal surgeries) are performed throughout Europe each year, the bacterial communities associated with the human gallbladder and its disease states remain unknown. Studies are lacking that characterize the effects of cholecystectomies on the gut microbiome. Without the ability to regulate bile entering the duodenum during food intake, it is expected that gallbladder removal will lead to downstream changes in the intestinal population. Here, the microbial composition of human bile, gallbladder mucosa, and biopsies of surgically removed healthy gallbladders (adherent and non-adherent microbiota) will be investigated using 16S rRNA metagenomics. The profiles will be compared to samples of a second cohort undergoing emergency cholecystectomies, in order to identify possible biomarkers for gallbladder disease. Once the gallbladder microbiome has been elucidated, the impact of its removal on the gut microbiome will be assessed. Using molecular and cultivation based techniques, on stool samples (collected during the recovery period) and analyzed for community composition, metabolomics, bile, fat and energy content. GallBiome will form the basis for establishing relationships between gallbladder microbiota, gut microbiota, and human health with a view to informing future development of diagnostics and therapeutics. Ultimately, characterization of the core gallbladder microbiome has important biological and medical implications with potential to lower the risk and incidence of cholelithiasis.

Keywords: gallbladder,microbiome,biomarkers,health,disease
3D Model Catalysts to explore new routes to sustainable fuels (3MC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-11-30
Duration (months): 63.0
Total project cost (EUR): 1999625.0
EU funding (EUR): 1999625.0
Participants: 1
Project status: CLOSED

Currently fuels, plastics, and drugs are predominantly manufactured from oil. A transition towards renewable resources critically depends on new catalysts, for instance to convert small molecules (such as solar or biomass derived hydrogen, carbon monoxide, water and carbon dioxide) into more complex ones (such as oxygenates, containing oxygen atoms in their structure). Catalyst development now often depends on trial and error rather than rational design, as the heterogeneity of these composite systems hampers detailed understanding of the role of each of the components. I propose 3D model catalysts as a novel enabling tool to overcome this problem. Their well-defined nature allows unprecedented precision in the variation of structural parameters (morphology, spatial distribution) of the individual components, while at the same time they mimic real catalysts closely enough to allow testing under industrially relevant conditions. Using this approach I will address fundamental questions, such as: * What are the mechanisms (structural, electronic, chemical) by which non-metal promoters influence the functionality of copper-based catalysts? * Which nanoalloys can be formed, how does their composition influence the surface active sites and catalytic functionality under reaction conditions? * Which size and interface effects occur, and how can we use them to tune the actitivity and selectivity towards desired products? Our 3D model catalysts will be assembled from ordered mesoporous silica and carbon support materials and Cu-based promoted and bimetallic nanoparticles. The combination with high resolution characterization and testing under realistic conditions allows detailed insight into the role of the different components; critical for the rational design of novel catalysts for a future more sustainable production of chemicals and fuels from renewable resources.

Keywords: supported nanoparticles,3d nanostructures
Full Stack Digital Plant Scan and Work (SCAN and WORK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Automotive and aerospace companies manufacture time-consuming and expensive physical prototypes for testing. Alternatively, expensive design and simulation software can be used but is often out of alignment with real engineering needs. Our solution is the first cloud platform where users can make digital twins of manufacturing facilities coupled with 3D design and browser virtual product simulation. The added value to customers is cloud access to 3D scans with multiple key software packages, no full ownership costs, no need for own hardware with pay as you need pricing. Customers: all manufacturing/construction value chain players involved in product design: OEMs (Original Equipment Manufacturers), their Tier 1 and 2 suppliers, down to all small companies and individual designers/workers. Strategy: offer services online, assessible worldwide with transparent pricing. The prototype is TRL 7 validated by e.g. OEMs Mercedes and Volkswagen with MAN and Hyundai in the Advisory Board. Business model: IT service implementation fee, clients pays either: one-off payment; monthly fees or a commission. In average, we charge 1,5€ per square meter. For each core-hour we charge 1€; 1 core-hour is 1 software package running for 1 hour in 1 computing core. We buy software licenses and computing cloud to sell core-hours of computing, fractioning fixed costs into hourly computation units. We raised 500K€ early stage funding from investors Carl Geallad and KIC Innoenergy and 121.5K€ grant from the Portuguese Environmental Fund. Our team has manufacturing and automotive industries insiders; founders have more than 15 years of experience in automotive and aerospace engineering. Manufacturing and construction building design and simulation software global market was 6.26 B$ in 2017 and is estimated to reach 13.45 B$ by 2022. We expect accumulated sales of 46.3 M€ until 2023. The feasibility study goal is to create a global go to market plan and prepare worldwide expansion.

Keywords: modelling and simulation,automotive,aeronautics,aerospace,construction
Fostering Earth Observation market uptake thanks to natural and holistic access to added value data generated through cutting-edge Artificial Intelligence technologies (SnapEarth)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Türkiye,Romania,Poland,Greece,France,France,France
Call: Copernicus market uptake (H2020-SPACE-2019, 2019)
Start date: 2019-12-01
End date: 2022-11-30
Duration (months): 36.0
Total project cost (EUR): 2672101.79
EU funding (EUR): 1995031.26
Participants: 8
Project status: CLOSED

SnapEarth will unlock new value, derive actionable service ideas on top of EO big data collections, and anticipate future priorities by leveraging cutting-edge Artificial Intelligence and Cloud technologies and tools. Thanks to an innovative cloud agnostic product, SafeScale that is already operational on Copernicus RUS project led by CSSI, users and service providers on top of SnapEarth will benefit, in a transparent way, from processing platforms and data collections provided by any of the future C-DIAS and any cloud provider. This cloud brokering solution is providing a performant, cost effective environment, also protecting their investment, for the future third parties which are building their own services. The major breakthrough of SnapEarth comes with a new data analytics service, EarthSignature, which aims to automatically extract semantic information from satellite imagery. The extracted semantic information will be indexed by QWANT search engine and then be easily accessible to a wide range of user communities. EO experts and third parties will be able to train deep learning processing chains using their database of labelled EO images. The database will be near real time enriched. Therefore, SnapEarth allows the market move from analysing EO Big Data towards realizing Fast Data. It makes possible to buy basic imagery analysis as a commodity – much like we buy foundation data today. Several user communities are ready to engage in this new approach. SnapEarth proposes already several pilots projects. The first one (EarthSearch) will boost QWANT number of users through access to this wealth of data through natural language. The second one (EarthPress) involves press users who are very interested having contextual data linked to news. The following ones are linked to several EO vertical markets: EarthClimate, Agri, and Food. The last one EarthSelf-service is dedicated to professional third parties in the same model of the DIAS but ensuring independence.

Keywords: artificial intelligence and cloud agnostic technologies,deep learning,natural processing,language,web search engine
MAgnetoplasmonic NAnocavities for active COntrol of LIght POlarization (MANACOLIPO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Enhancing magneto-optical (MO) effects is crucial for the size reduction of key photonic devices based on non-reciprocal propagation of light and for active nanophotonics. Magnetoplasmonics merges the concepts from plasmonics and magneto-optics to achieve an enhancement of MO effects by using dipolar plasmonic resonances in magnetic nanoantennas. However, the achievable MO enhancement is still too small for practical applications due to two limiting factors: the low Q-factor of the dipolar plasmon resonances in metallic nanostructures and their bright nature that enhances the radiation of light with the original incident polarization, thereby reducing the polarization change induced by the plasmon-assisted MO amplification. Very recently, the new conceptual path of hybridization of dipolar plasmon modes with multipolar dark modes using hybrid magnetoplasmonic nanocavities was proposed as a way to overcome both the above-mentioned limitations. This project will explore this new conceptual path, which was proposed by the Supervisor in a proof-of-concept work, to devise advanced approaches to harness the hybridization of multipolar dark modes with bright modes and achieve an unprecedented enhancement of MO effects. To this purpose, new types of nanocavities are proposed and will be fabricated and studied in this project. The new approaches and devices developed in this project will contribute to achieving a deeper understanding of the nanoscale light-matter interactions and are likely to have a huge impact on forthcoming photonic nanotechnologies for active manipulation of light polarization. By tackling novel and relevant challenges in modern nanophotonics, this project represents a unique platform for the training of the applicant, who has an established fundamental background that will be complemented with an interdisciplinary and technology-related research profile enhancing his competence and decisively support him in attaining a leading independent position.

Keywords: magneto optics,magnetoplasmonics,nanophotonics,plasmonics