Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the behavioural mechanisms underlying the evolution of disassortative mating (DMateChoice)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Understanding the origins and mechanisms of biological diversity is a central aim of evolutionary ecology. Mating behaviours contribute to shaping diversity because of their importance in determining the genotypic composition of populations and the association among adaptive traits. Interestingly, recent work shows that disassortative mating – the tendency of dissimilar individuals to mate together – may stably maintain character diversity within populations. Examples include traits showing heterozygote advantage, like immunity genes. Yet, little is known about the behavioural and genetic basis of disassortative mating linked to traits under balancing selection. The proposed project will fill in this knowledge gap by utilizing the polymorphism in predator warning colour patterns in a butterfly as a model to study disassortative mating at a locus under heterozygote advantage. In particular, I will examine the role of male mating cues on female preference, test theoretical predictions of the evolution of disassortative mating, and assess if disassortative mating may be modulated by female’s experience. My results will provide novel mechanistic insights into this behaviour and improve our understanding of how interactions between behavioural, ecological, and genetic factors can shape diversity. This project will use a novel and multi-disciplinary approach that combines behavioural experiments, chemical analyses, and electrophysiology of mate cues with genetics to investigate the behavioural and genetic basis of disassortative mating unprecedented detail. I will acquire new skills and knowledge in evolutionary biology and genetics that complement my background in behaviour and cognition. In return, I will share my expertise in topics different from the research done at the host institution, which will certainly spark new research ideas and collaborations.

Keywords: mate choice,disassortative mating,sexual selection,warning signal polymorphism,balancing selection
Synbio for cOmpartmentalized caRotenoids sToragE in Diatoms (SORTED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: SIGNED

Carotenoids, prized for their antioxidant properties, are essential precursors for crucial human vitamins and, in plants and algae, they play roles in light absorption and photoprotection against excessive light-induced damage to photosynthesis. However, it is very challenging to achieve carotenoid market- required yields. Carotenoids complex chemical synthesis in fact, limits the possibility to obtain them artificially while in plants (i.e., the main natural producers) excessive carotenoids in chloroplasts can disrupt thylakoid membranes, making biotechnological manipulation aimed to increase carotenoid yield particularly hard. To address this problem, a sustainable approach is crucial, and microalgae offer a promising solution as natural, scalable carotenoid producers. A novel strategy involves repurposing cellular factories to overcome chloroplast limitations for carotenoid biosynthesis and accumulation. Diatoms, like Phaeodactylum tricornutum, are ideal candidates due to their multiple cellular compartments, including the periplastidial compartment (PPC), suitable for carotenoid storage, and access to precursors synthesized through various cellular pathways. Moreover, diatoms excel as synthetic biology platforms with efficient genetic tools, modular DNA assembly, and genome editing capabilities. The SORTED project aims to advance understanding through a multifaceted approach. Firstly, we will investigate prenyltransferases (PTSs) in P. tricornutum's cytosol to unveil their role in carotenoid precursor synthesis (Objective 1). Subsequently, rational redesign will enable the extraplastidial relocation of the carotenoid biosynthetic pathway (Objective 2). Furthermore, we will assess the physiological implications of genetic modifications on performance (Objective 3). Through SORTED, we anticipate gaining innovative insights into diatom carotenoid production, revolutionizing both biotechnology and our fundamental understanding of cellular dynamics.

Keywords: biosynthesis,carotenoids,microalgae,synthetic biology,isoprenoids
Spatial 3D Semantic Understanding for Perception in the Wild (SpatialSem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Understanding the 3D spatial semantics of the world around us is core to visual perception and digitization -- real-world environments are spatially three-dimensional, and must be understood in its 3D context, even from 2D image observations. This will lead to spatially-grounded reasoning and higher-level perception of the world around us. Such 3D perception will provide the foundation for transformative, next-generation technology across machine perception, immersive communications, mixed reality, architectural or industrial modeling, and more. This will enable a new paradigm in semantic understanding that derives primarily from a spatially-consistent, 3D representation rather than relying on image-based reasoning that captures only projections of the world. However, 3D semantic reasoning from visual data such as RGB or RGB-D observations remains in its infancy, due to challenges in learning from limited amounts of real-world 3D data, and moreover, the complex, high-dimensional nature of the problem. In this proposal, we will develop new algorithmic approaches to effectively learn robust visual 3D perception, with new learning paradigms for features, representations, and operators, to encompass 3D semantic understanding.
The EBO-PEP project : EBOla Zaïre Post-Exposure Prophylaxis, preparedness and efficacy evaluation during outbreak in Central and West-Africa. (EBO-PEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,Congo, The Democratic Republic of the,Guinea,Spain,Côte d'Ivoire,Senegal,Belgium
Call: Research to rapidly evaluate interventions on Ebola outbreaks in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 3435775.0
EU funding (EUR): 3435775.0
Participants: 11
Project status: SIGNED

Ebola Virus Disease (EVD) outbreaks represent significant threats to public health and require effective countermeasures to minimize transmission and reduce mortality. The r-VSV-ZEBOV vaccine (Ervebo®) demonstrated efficacy in protecting contacts and contacts of contacts and has since been widely used in ring vaccination strategies in the Democratic Republic of Congo (DRC) outbreaks. However, its efficacy for high-risk contact is more and more debated. Furthermore, two monoclonal antibodies (mAbs), Ansuvimab (Ebanga®) and REGN-EB3 (Inmazeb®), have demonstrated their efficacy as treatment in reducing mortality in patients with EVD. With the availability of these management and prevention tools, the question of their use in Post-Exposure Prophylaxis (PEP), to protect individuals from contracting EVD after a high-risk contact, is more important than ever to effectively control EVD. The EBO-PEP consortium built on a highly successful collaboration between African and European institutions and NGOs. and allow to maintain a network for knowledge sharing and consortium collaboration to fight against EVD in Africa. The overall objective of the EBO-PEP project is to increase the portfolio of therapeutics tools against EVD, by evaluating a PEP strategy for high-risk contact. This will be accomplished through a multi-epidemic, multi-countries phase III clinical trial to test the efficacy of mAbs used as PEP during outbreak period. To address this objective, we focus our activities on 3 specific objectives: - to set up a multi-epidemic, multi-site and multi-countries phase III clinical trial in Africa to test the efficacy of mAbs used as PEP for EVD high-risk contact (EBO-PEP study), - to strengthen the capacities of clinical researchers and increase the knowledge and engagement of the community on EVD research, - to define the best PEP strategy for high-risk contact and to advocate for PEP implementation in the countries affected by EVD.

Keywords: ebola virus disease,post exposure prophylaxis,monoclonal antibodies,multi epidemic,preparedness
European Partnership Animal health and Welfare (EUPAHW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: COFUND actions
Partnership: Animal Health and Welfare (co-funded)
Countries involved: Belgium,Spain,Austria,Germany,Slovakia,France,Italy,Denmark,Ireland,Greece,Estonia,Portugal,Sweden,Norway,Lithuania,Latvia,Netherlands,Slovenia,Finland,Poland,Georgia,Türkiye,Switzerland,United Kingdom
Call: European partnership on animal health and welfare (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-01-01
End date: 2030-12-31
Duration (months): 84.0
Total project cost (EUR): 114467317.52
EU funding (EUR): 57233657.9
Participants: 98
Project status: SIGNED

The European Partnership Animal Health & Welfare (EUP AH&W) will provide society with a sustainable production for both terrestrial and aquatic animals, where infectious animal diseases are prevented and controlled, antimicrobials are used prudently, and a high level of animal welfare is provided in every phase of animal’s life. The objectives of the EUP AH&W fit in with the European Green Deal and its associated Farm to Fork strategy for a fair, healthy, and environmentally friendly food system. From its start, the EUP AH&W includes 56 Research Performing Organizations (RPO) and 30 Funding Organizations (FO) from 24 EU and non-EU European countries. The RPO partners provide significant research-based advice to competent authorities in the EU and are the backbone of Animal Health & Welfare (AHW) research in Europe. They collaborated to transpose 16 actions from the EUP Strategic Research and Innovation Agenda (EUP SRIA) into 17 joint internal projects. The FO partners will contribute through external calls to further R&I actions from the EUP SRIA not covered by internal activities as they require other expertise or industry participations. Due to the close link between animal health and welfare and human well-being, the One Health-One Welfare perspective will take a prominent place in the EUP AH&W. The mobilisation of resources from both RPO and FO together with EC co-funding will allow the Partnership to achieve ambitious goals for AHW at the transnational level, in Europe and beyond. New technologies develop rapidly and provide new R&I opportunities for AHW, to be included in the EUP AH&W as joint internal activities and projects initiated through external calls. The management will set up appropriate procedures and methodologies to ensure a fair coverage of AHW, of terrestrial and aquatic animal species, the various priority areas and to ensure the uptake of the results in the midterm (outcomes) and long term (impact) for science, society and policy.
Cofactors and Minerals Before Enzymes: Unravelling the Pre-Enzymatic Path of Autotrophic CO2 Fixation (CoBeEn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1393703.0
EU funding (EUR): 1393703.0
Participants: 1
Project status: SIGNED

There are two approaches to the emergence of life: bottom up and top down. This means on one hand, we can start with simple geochemical reactions and try to synthesize increasingly complex molecules and reaction networks from there. On the other hand, we can start with life as we know it and try to decomplicate the chemical reactions that run it to find a common denominator. Both approaches have yielded important insights, but they also have their limitations. So far, the two approaches are far away from ultimately converging. CoBeEN aims to reconcile geochemistry and biochemistry by focussing on the most ancient carbon fixation route: the Wood-Ljungdahl pathway (WLP). This autotrophic pathway uses the electrons of hydrogen to fix CO2, a reaction that also occurs abiotically – using minerals as catalysts instead of enzymes. The mere transition from minerals to enzymes seems far-fetched, given the leap in complexity required. However, organic cofactors or coenzymes, simpler organic molecules assisting enzymatic reactions by being truly recyclable reaction partners, are hypothesized to have preceded enzymes. They are pivotal in theoretical reconstructions of autocatalytic, non-enzymatic networks describing a minimal metabolism based on carbon fixation. CoBeEn postulates that coenzymes played a central role in enabling the transition from mineral-based CO2 fixation to enzymatic carbon metabolism. CoBeEn will experimentally link key metabolic cofactors of the WLP to mineral-assisted catalysis. The goal is to understand the transition from environmental reactions to metabolic functions by elucidating how metabolic pathways and the molecules employed by them were selected by the environment. By mapping the understudied interactions between chemically active environments and metabolism, we will gain insights into their mechanistic interdependencies before they were separated by the origin of cellular organization.

Keywords: emergence of metabolism,luca,coenzymes,mineral catalysis
Visualizing Hebrew Knowledge: Shape and Text in Scientific and Philosophical Manuscripts (VisHeK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Between the 10th and 12th centuries CE, the major players of the Mediterranean included the Republic of Venice, Norman Sicily, Fatimid Egypt, and North Africa, the Iberian Peninsula and Byzantium. Each of these centres was inhabited by a mixed population of Jews, Muslims, and Christians who maintained networks of trading partners, exchanging not only goods but also ideas, texts, and, as we will see, art. From the 12th century onward, Jewish scholars, mainly in Spain, Provence, and Italy, began translating scientific works from other languages; Hebrew became dominant as a scientific language. Jews were aware of the scientific developments and the translators gave different reasons justifying their motivations, such as the contempt displayed by foreign peoples for Jewish culture in general, or the conscious desire to embrace the knowledge and development of the surrounding culture in this field. While researchers have examined which and how scientific texts were translated from Latin and Arabic into Hebrew, they have paid little attention to whether and how Jews adopted the visual elements in these texts. Such visual components in Hebrew manuscripts of science and philosophy, mostly in the form of diagrams combining text and shape, stand at the heart of this project. Different diagrams that develop ideas in these fields will be analyzed for the first time, using methods from the disciplines of art history and history of science, with additional attention to manuscript studies and cultural history, emphasizing the interdisciplinary methods required in this field. Although the diagrams are found in Hebrew manuscripts, they are part of a wider context of Latin and Arabic manuscripts. The main aim of this integrative study of the transmission of text and image is to contribute to our understanding of the transfer and sharing of knowledge between different cultures.

Keywords: jewish history,history of science,medieval manuscripts,illuminated manuscripts,jewish art history,hebrew manuscripts,jewish christian relations,interculturality,discourse,visual language
Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs (SESAHME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking. This is due to the complex nature of the bone marrow. Therefore, the goal of SESAHME is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia. This will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the future. To achieve this, the objectives of SESAHME are to 1) establish a method that allows to determine the immune microenvironment composition in human formalin-fixed paraffin-embedded samples of the bone marrow, which has the potential for high-throughput screening and being cost effective at the same time; and 2) to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myeloma/acute lymphoblastic leukaemia development and progression. SESAHME will allow the fellow to independently carry out a project which will set the ground to build upon an own, individual research profile to eventually become an independent researcher. Key transferable training will further improve the employability and career prospects of the fellow, as well as increase the fellow’s communication abilities. The host offers a multi-disciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches. The fellow brings international and specialised wet-lab experience that will facilitate knowledge exchange and increase R&I capacity. Finally, SESAHME will increase the global attractiveness of the host via concrete dissemination activities.

Keywords: bioinformatics,systems biology,cancer and its biological basis,rare diseases,anticancer therapy,personalised medicine,stem cell biology,myeloma,bone marrow,haematology,microenvironment
MHz rate mulTiple prOjection X-ray MicrOSCOPY (MHz-TOMOSCOPY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Sweden,Japan,Slovakia,Italy,United Kingdom
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 3154350.0
EU funding (EUR): 3154350.0
Participants: 9
Project status: SIGNED

Modern enabling technologies, such as additive manufacturing or cavitation peening used in the aerospace and automotive industries, suffer from a lack of diagnostic tools. To date, one cannot provide relevant volumetric information about the fast processes involved. The realization of this project will break the current limits in fast, 4D X-ray microscopy by three orders of magnitude. It will be possible to visualize and characterize dynamics reaching velocities up to ~km/s for the first time with micron-scale resolutions. Instead of sample rotation, we will generate multiple X-ray probes and virtually rotate them around the sample to obtain with a single exposure multiple angular views simultaneously. Using modern X-ray sources with very high brilliance, each such 3D frame may be sampled at kHz rates at synchrotrons and even MHz rates at X-ray free-electron laser sources. This will unlock access to 4D observation of processes with velocities never before possible. 4D imaging of opaque samples at MHz rates enables insights across a range of sectors and industries. In cavitation peening, an industrially relevant phenomenon for aerospace and new materials, we have no volumetric information, due to its high speed. This breakthrough will be achieved by the construction of a prototype that will demonstrate MHz rate tomoscopy at the European XFEL, taking advantage of world-unique European laboratories for the benefit of industry. Observing MHz-fast phenomena in opaque samples enables an entirely new branch of research, with possibilities for all sectors where such fast phenomena has, to date, been left to simulations and speculations. For industry and society, it would open new possibilities in the development and management of several techniques, including laser driven additive manufacturing, shock waves, fractures, evaporation, light alloy metallurgy, fast fluid dynamics, and cavitation phenomena.

Keywords: 4d x ray microscopy,fast phenomena,in situ,mhz x ray microscopy,machine learning,moda4d x ray microscopy,fast phenomena,in situ,mhz x ray microscopy,machine learning,modal data decomposition