Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Semi-SOlid-state LI-ion batteries FunctionalLY integrated in composite structures for next generation hybrid electric airliner (SOLIFLY)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Italy,Italy,Germany,France
Call: High power density / multifunctional electrical energy storage solutions for aeronautic applications (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1355257.5
EU funding (EUR): 1355257.5
Participants: 6
Project status: SIGNED

SOLIFLY responds in full to the challenges of the JTI-CS2-2020-CfP11-THT-11 call, “High Power density / multifunctional electrical storage solutions for aeronautic applications”, by developing and combining two structural battery concepts: (i) multi-functional materials with a high degree of integration - Coated Carbon Fibres (CCF), and (ii) multi-functional elements with a medium degree of integration - Reinforced Multilayer Stack (RMS). The project has three vertical objectives: • exploring and advancing a non-conventional semi-solid-state Li-ion battery material formulation suit-able for structural batteries: NMC622 (cathode), Si/C (anode) and bicontinuous polymer-ionic liquid electrolyte (BCE), i.e. NMC622|BCE|Si/C; • enabling the functional integration of this material within the CCF and RMS concepts, upscaling them to the level of a representative aeronautic stiffened panel structure, i.e. SOLIFLY demonstrator; • characterising the electrochemical and mechanical performance of this demonstrator. These vertical objectives are complemented with a horizontal one: to tailor SOLIFLY to the needs of the aeronautic industry. This is achieved by factoring end-user requirements and specifications into the design process right from the start, and by including airworthiness and manufacturing criteria together with a technology roadmap and TRL scale-up strategy. The SOLIFLY demonstrator aims at achieving a gravimetric energy density at cell level between 100 and 180 Wh/kg, a nominal discharge rate of 1C, being capable of sustaining 300+ cycles at 0.1C with 90% capacity retention and achieving TRL 4 by the end of the project (2023). SOLIFLY ultimately aims at supporting the long-term development of the European aeronautic industry, delivering the first aeronautic stiffened panel with an integrated semi-solid-state battery, and paving the way for making structural batteries a viable technology for the next generation hybrid electric airliner.

Keywords: structural batteries,coated carbon fibres,reinforced multi layer stack,nmc622 cathode,bicontionuous electrolyte,c anode,stiffened panel with embedded batteries
SOCIETY Rinascimento (SOCIETY Rinascimento)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-04-30
Duration (months): 12.0
Total project cost (EUR): 208293.75
EU funding (EUR): 208293.75
Participants: 7
Project status: CLOSED

Overwhelmed by a pandemic that destroyed consolidated habits, researchers must think ahead and focus on what is next. The theme that we propose for the 2021 edition of the ERN is Rinascimento, the fruitful period that stemmed from the great plague raging Europe in the fourteenth century. The Italian Renaissance is known for the spectacular growth of arts, literature, and philosophy but it was rooted in times of great difficulties and major societal transformations, demonstrating how challenges can be the gateway to notable developments. The fight against the pandemic in 2020 has diverted public attention from the significant challenges humankind faces: climate change is already affecting our lives and safety; a blind development pays little attention to people?s lives and the environment, fostering widespread inequality. A new Rinascimento needs to start here, where the core of the problems lies: revisiting the economic, political, and social relations among different countries and cultures, and re-thinking how we interact with the planet and its delicate equilibria. Researchers can play a role in building a new vision of the future, but a real shift in mindset is only possible when society becomes an active actor of change. SOCIETY Rinascimento will remind the public that challenging times may provide the right context for a needed change. Thanks to its network of stakeholders, SOCIETY Rinascimento will offer a wide range of activities and topics to target different public kinds. We will base our engagement strategy on three well-established pillars: an extended partnership and a long-lasting program of activities; diversity of topics and approaches; special attention to the Next generations. Visitors will see first hand how researchers work to build a new idea of society: resilient, environmentally friendly, inclusive, and fair. Each participant will have a chance to embrace an active role in promoting societal change.

Keywords: public engagement,event,dissemination,cultural heritage,schools,young people,edutainment,gender balance
An avian model for understanding adaptations and modulatory drivers of avian migration (MIGRADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Migratory birds have evolved exceptional adaptations: they can invert their circadian rhythms turning from diurnal to nocturnal, undergo rapid changes in body mass and fat stores, and cope with repeated cycles of fasting and feeding as they alternate between sustained migratory flights and refuelling stopovers. The genetic and physiological mechanisms underlying such remarkable adaptations remain poorly understood. Studies on small, wild-caught Passerines have unravelled several aspects of migratory physiology. However, they have not allowed to experimentally uncouple the suite of endogenous and environmental factors underlying the dynamics of the migratory state. I will circumvent such limitations by pioneering a novel experimental approach using two closely related, larger avian model species that are better suited for multi-scale investigations of proximate mechanisms and offer a direct comparison between migratory and sedentary individuals. The key goals of this post-doctoral project are to determine: (i) The physiological mechanisms associated with the activation and deactivation of the migratory state; (ii) Which genes modulate such transition via changes in their expression within key target organ tissues; (iii) Whether endocrine signals trigger the switching of the migratory state. This project will undertake a novel comparative and integrative approach to reveal completely new insights into the importance of understanding genetic and physiological pathways underlying the dynamics of the migratory state. It will also provide fruitful insights to both poultry science and biomedical research on the importance of nutrition on health and food safety.

Keywords: avian migration,phenotypic adaptations,melatonin,ghrelin,transcriptomics
Targeting hypothalamic inflammation in obesity and diabetes (HypoFlam)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2402280.0
EU funding (EUR): 2402280.0
Participants: 1
Project status: CLOSED

Despite educational, political and biomedical research efforts, obesity, type 2 diabetes and related metabolic diseases are increasing worldwide at an alarming rate. Failure to deliver efficient and safe medical therapies is a result of our incomplete understanding of the pathogenesis of the metabolic syndrome. Current knowledge implicates impaired CNS control over appetite, body weight and systemic metabolism as a key pathogenic process leading to obesity and type 2 diabetes. Yet, years of intense study focused on neuronal signalling have produced no transformative breakthroughs. Control centers located in the hypothalamic arcuate nucleus (ARC) serve as primary targets of afferent hormone signals regulating systemic control of body weight and metabolism and appear to be most affected by high fat high sugar (HFHS) diets. Recently, we discovered that in the early stages of the metabolic syndrome induced by consumption of a HFHS diet, significant changes beyond neuronal pathologies occur in hypothalamic nuclei responsible for metabolic control, such as the ARC. Specifically, we observe in hypothalami of mice, rats and humans increased reactive microgliosis and astrocytosis as well as a decline in regulatory T-cell presence. We hypothesize that hypothalamic inflammatory processes triggered by hypercaloric environments impair hormone sensing, disrupt glial homeostasis and incapacitate these hypothalamic control centers, ultimately contributing to development of obesity and diabetes. Building on a considerable body of preliminary data, we will apply an array of advanced technologies to A) develop a functional understanding of the pathophysiology of diet-induced hypothalamic inflammation, B) test if hypothalamic inflammation plays a critical role in the development of the metabolic syndrome, and C) attempt to target these novel pathogenic processes for the first time using novel targeted therapeutic approaches.
Multicellular regulation of insulin secretion from pancreatic islets (OptoBETA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 1681468.0
EU funding (EUR): 1681468.0
Participants: 1
Project status: CLOSED

Type 2 diabetes mellitus, one of the major healthcare challenges of our time, is characterized by failure of beta cells to functionally adapt to increased peripheral insulin resistance. The resulting chronic elevations in blood glucose concentration are associated with heart, kidney, liver, nerve and retinal disease, as well as cancer. Here, by combining novel optogenetic, photopharmacological and innovative imaging approaches, we aim to unravel the complexity underlying the multicellular regulation of insulin secretion from islets of Langerhans during health and disease. In particular, we will examine a role for privileged pacemakers/hubs in orchestrating population responses to stimuli, identify what makes these specialized cells unique at the RNA/protein level, and understand how they contribute to islet development and failure. Furthermore, we will address whether the intraislet regulation of insulin secretion operates in vivo to determine glucose homeostasis, focusing on the neural-endocrine interface. Lastly, the mechanisms underlying islet cross-talk will be investigated directly in situ within the pancreas of living mice, paying close attention to the roles of the vasculature and secreted factors. As such, these studies should unveil a new route for restoration of insulin secretion in man, as well as provide the foundation for the de novo construction of islets for transplantation.

Keywords: type 2 diabetes,beta cell,islet
The Role of the Metabolism in Mosquito Immunity against Dengue virus in Aedes aegypti (MetAeAvIm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-10-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Mosquito-borne diseases remain among the most prevalent diseases in the world with. At present, more than half of the world population lives in areas where mosquito vectors are present. Vector control is one of the cornerstones of arbovirus control. However, insecticide-resistant population are emerging demanding new tools of vector control to be developed. It is known that mosquito immunity can be modulated by its physiological state and nutritional status. However, we still lack an integrated view of how immune mechanisms and metabolic pathways interact to control viruses at different stages of infection. In order to obtain a more detailed understanding of the gene expression profile associated with immunity to Dengue virus (DENV), we performed a genome-wide analysis of the transcriptome of susceptible and resistant individuals from the same population of mosquitoes. Metabolic pathways represented the majority of the differentially expressed gene sets identified by our analysis, suggesting that differences in metabolism determine DENV resistance. These results support the hypothesis that mosquito metabolism plays a key role in controlling mosquito susceptibility to viral infections. In this project, we will characterize the metabolism of mosquitoes and characterize pathways and genes that are determinants for DENV resistance. We will study the metabolism of A. aegypti, comparing susceptible and resistant mosquitoes, measuring specific metabolic outputs and also performing unbiased high-throughput metabolomic studies. In parallel, we will perform reverse genetic screenings to validate whether metabolic pathways and biological processes identified in our transcriptomic analysis have a role in vector competence to DENV. Finally, we will apply the CRISPR/Cas9 technology and classical transgenesis to target genes and pathways that affect vector competence in mosquitoes. Together, this project will allow for a deeper mechanistic study of mosquito antiviral immunity.

Keywords: aedes mosquito dengue vector
A patient-friendly blood collection device that produces pure plasma samples for simple laboratory analysis (HemaXis DX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Blood analysis is undoubtedly one of the most powerful medical diagnostic tools. In most cases, blood tests are often a part of regular check-up undertaken yearly to diagnose certain abnormal values, such as low haemoglobin or high/low sodium or potassium levels. In Europe tens of millions of blood tests are performed annually. Blood collection techniques have not significantly changed since 1950’s: venepuncture is the most routinely performed procedure and skilled healthcare professionals and complex procedures to attain adequate blood samples are still required. In addition to an outdated process, before the blood is tested, it needs to be precisely prepared for analysis. Most routine laboratory tests are performed on plasma, which is the liquid component of blood which contains dissolved proteins, glucose, clotting factors, mineral ions, hormones and drugs. However, the preparation of the blood plasma is a time consuming and costly process. HemaXis DX is a dried blood plasma spot device which uses microfluidics technology to collect and prepare accurate volume of controlled samples of plasma immediately ready to be analysed in laboratory allowing sample preparation directly at the point of collection. HemaXis DX allows the clinician/lab technician to collect the required drops of blood from the fingertip in a minimally invasive, fast and painless manner. Unlike the traditional venepuncture, this method of collecting blood does not result in any side effects. A simple finger prick is needed to extract a minimal amount of blood in single droplets in a matter of seconds. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project DBS System will finalize its engineering of HemaXis DX before scaling up for clinical studies and system industrialization.

Keywords: blood sampling,plasma,microfluidic channel,plasma separation,microfluidic chip,laboratory
Intermediate Chaos (IChaos)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1696936.74
EU funding (EUR): 1696936.74
Participants: 1
Project status: CLOSED

The transition from order to chaos has been a central theme of investigation in dynamical systems in the last two decades. Structures that exhibit a mix of deterministic and chaotic properties, for example, quasi-crystals, naturally arise in problems of geometry and mathematical physics. Despite intense study, key questions about these structures remain wide open. The proposed research is an investigation of intermediate chaos in ergodic theory of dynamical systems. Specific examples include systems of geometric origin such as interval exchange maps, translation and Hamiltonian flows on surfaces of higher genus, symbolic substitution systems important in the study of quasi-crystals as well as dynamical systems arising in asymptotic combinatorics and mathematical physics such as determinantal and Pfaffian point processes. Specific tasks include computation of the Hausdorff dimension for the spectral measure of interval exchange maps (problem posed by Ya. Sinai), limit theorems for Hamiltonian flows on surfaces of higher genus (question of A. Katok), development of entropy theory and functional limit theorems for determinantal point processes and a description of the ergodic decomposition for infinite orthogonally-invariant measures on the space of infinite real matrices (the real case of the problem, posed in 2000 by A. Borodin and G. Olshanski, of harmonic analysis on the infinite-dimensional analogue of the Grassmann manifold). The project consolidates the proposer's past work, in particular, his limit theorems for translation flows (Annals of Math. 2014), his proof of the 1985 Vershik-Kerov entropy conjecture (GAFA 2012) and his solution of the complex case of the Borodin-Olshanski problem (preprint 2013). The proposer is currently PI of project ANR-11-IDEX-0001-02 (1.11.2013--30.10.2015; budget 360000 euro) under the Programme "Investissements d'avenir" of the Government of the French Republic.

Keywords: limit theorems in ergodic theory,translation flows,interval exchange maps,substitutions,spectrum,determinantal point processes,entropy,shannon mcmillan breiman theorem,ergodic decomposition
Agrobiological products for crop production improvement: a novel approach towards a sustainable agriculture (BIOAGRIBOOSTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-02-29
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Iden Biotechnology S.L. is a private company founded in 2006 with the mission to serve the needs of the agri-food industry. We focus our activity in the development and commercialization of high-quality technology, working from an agrobiotechnological approach. The success of our business model relies on a deep understanding of the agri-food sector needs, thanks to a close collaboration with the industry. Over the past years we have been engaged in the development of innovative products and technologies for plant productivity enhancement. In the context of these projects, we came up with a disruptive technology for the production of a new agrobiological product, particularly a biostimulant, which was found to increase crop production by 20-25%, while at the same time enabling a reduction of the use of agrochemicals by 65%. Unlike the competing biostimulant products, BIOBOOSTER proposes a completely different approach, which will not entail any effect in soil because in fact our biostimulant is not based on any substance aimed at modifying the soil structure. The overall concept of the BIOBOOSTER project is based on the discovery that the volatile elements emitted by fungal fermentation, stimulate plant growth without the need of any physical contact of these fungi with the plant or the soil. As the effect is produced by these volatile elements, which do not remain in contact with the plant/soil, there is no possible way for soil structure modification in the long term. The innovation of the BIOBOOSTER project relies on two main concepts: a) the production process and b) the biostimulant product. The both innovations have been protected by an international patent application (PCT/ES2011/000125) and now we seek performing the necessary steps towards production scaling up and product commercialization.

Keywords: biostimulants,sustainable agriculture,agrobiologicals