Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Data Analysis Pipelines for Large-Scale Data Management, HPC, and Machine Learning (DAPHNE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Austria,Germany,Germany,Switzerland,Switzerland,Slovenia,Poland,Greece,Denmark
Call: Big Data technologies and extreme-scale analytics (H2020-ICT-2020-1, 2020)
Start date: 2020-12-01
End date: 2024-11-30
Duration (months): 48.0
Total project cost (EUR): 6609665.0
EU funding (EUR): 6609665.0
Participants: 14
Project status: SIGNED

Modern data-driven applications leverage large, heterogeneous data collections to find interesting patterns, and build robust machine learning (ML) models for accurate predictions. Large data sizes and advanced analytics spurred the development and adoption of data-parallel computation frameworks like Apache Spark or Flink as well as distributed ML systems like MLlib, TensorFlow, or PyTorch. A key observation is that these new systems share many techniques with traditional high-performance computing (HPC), and the architecture of underlying HW clusters converges. Yet, the programming paradigms, cluster resource management, as well as data formats and representations differ substantially across data management, HPC, and ML software stacks. There is a trend though, toward complex data analysis pipelines that combine these different systems. Examples are workflows of distributed data pre-processing, tuned HPC libraries, and dedicated ML systems, but also HPC applications that leverage ML models for more cost-effective simulation. Major obstacles are (1) limited development productivity for integrated analysis pipelines due to different programming models, and separated cluster environments, (2) unnecessary data movement overhead and underutilization due to separate, statically provisioned clusters, and (3) lack of a common system infrastructure with good interoperability. For these reasons, DAPHNE’s overall objective is the definition of an open and extensible systems infrastructure for integrated data analysis pipelines. We aim at building a reference implementation of language abstractions (i.e., APIs and a domain-specific language), an intermediate representation, as well as compilation and runtime techniques with support for integrating and scheduling heterogeneous accelerator and storage devices. A variety of real-world, high-impact use cases, datasets, and a new benchmark will be used for qualitative and quantitative analysis compared to state-of-the-art.

Keywords: machine learning systems,large scale data management,high performance computing
How do biotic and environmental variation affect soil microbial community composition and functioning across spatial scales? (MICOCO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Soil microbial communities hold sway over numerous processes upon which we depend, driving the cycling of elements which sustain life, but also compromising food security and human health. Understanding the mechanisms driving existing soil microbial community diversity and function across disparate climates and ecological communities is key in order to determine future ecosystem responses to global change. Although studies aiming to characterise soil microbes are increasing in their scope, they will only capture the multifaceted interaction between diverse microbial communities if they measure the effects of above ground plant communities and the abiotic environment, when measured at appropriate scales across landscapes. The proposed MICOCO project will address these shortfalls to achieve the following objectives: [1] Determine the relative contribution of above ground plant community and soil abiotic conditions to SMC diversity and composition; [2] Determine how climate influences microbial community turnover at varying spatial scales; [3] Reveal the relative effects of microclimate, microbe-microbe associations, and microbe-plant associations on microbial function. These objectives will be achieved using novel datasets built on the latest techniques in the sampling of environmental DNA (eDNA). These were collected at local scales (1-100m) in an innovative climate controlled mesocosm, and at landscape scales (100m->100km) as part of pioneering national surveys of soils. Cutting edge modelling techniques will be used to generate microclimate measures, and the latest Joint Species Distribution Models will determine association patterns within soil microbial communities, coupled with functional trait databases to identify plant pathogens and appropriately infer interactions. MICOCO will thus help to reveal microbial community and species level responses to changes in climate, and improve our understand of the effects of global change on their functioning.

Keywords: metabarcoding,edna,microclimate,associations
Re-emerging Magic Molecules: The Medicalization of Psychedelics in the United States (ReMedPsy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2021-07-31
Duration (months): 36.0
Total project cost (EUR): 261208.8
EU funding (EUR): 261208.8
Participants: 3
Project status: CLOSED

This proposal presents a research-via-training project that will transfer knowledge from the U.S. to Europe and allow the experienced researcher to deepen her study of (re-)emerging scientific fields to advance her career significantly. The project explores how scientists and other actors currently re-frame psychedelics in a scientific model to make them into licensed medicines. Since their introduction into Western science and culture (1930s-60s), psychedelic substances such as psilocybin or LSD have been highly controversial. Although early research indicated promising psychiatric applications, Western governments began to see psychedelics as a threat to public health in the 1960s and placed them into the most restrictive drug category, ascribing them a high potential for abuse and no currently accepted medical use. After coming to an almost complete standstill for several decades, psychedelic research is slowly re-emerging since 2000, highlighting again their potential for treating mental health issues such as addiction, depression, or PTSD. Since neither the molecules nor regulations have changed, this project investigates which socio-political conditions have enabled this revival (e.g., changes in the scientific or broader culture, risk-benefit evaluations). It traces how the responsible re-integration of psychedelics is fostered through the interplay of actor constellations, the production of scientific knowledge, and sociotechnical imaginaries. Using a qualitative research methodology and approaches from Science and Technology Studies (STS), it focuses on three molecules that are at the center of contemporary research in the U.S. (the country currently at the forefront of psychedelic research): MDMA, psilocybin, and ketamine. The project results will yield important insights into how psychedelic science and society are co-produced, and provide timely policy recommendations with regard to drug classifications, and drug and public health policies.

Keywords: emerging science,psychedelics,regulation,politics,social studies of science,medicalization,drug development,drug policy
Syntax Meets Semantics: Methods, Interactions, and Connections in Substructural logics. (SYSMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,Spain,Italy,Italy,Italy,Australia,South Africa,Spain,Argentina,Italy,Singapore,Switzerland,Czechia,Czechia,United States,Netherlands,Japan,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 580500.0
EU funding (EUR): 504000.0
Participants: 25
Project status: CLOSED

Substructural logics are formal reasoning systems that refine classical logic by weakening the structural rules in Gentzen sequent calculus. While classical logic generally formalises the notion of truth, substructural logics allow to handle notions such as resources, vagueness, meaning, and language syntax, motivated by studies in computer science, epistemology, economy, and linguistics. Moreover, from a theoretical point of view, substructural logics provide a refined perspective of classical logic, since the former often exhibit features which are either absent or trivialised in the classical case. Traditionally, substructural logics have been investigated following three main approaches: proof theoretic, algebraic and abstract study. Although some connections among these approaches were observed long ago, in large part these practices developed in independence. As a result, the research directions, tools and motivations for each approach developed in relative isolation. The main objective of this project is to establish a network of collaborations between the experts of these diverse methods to investigate substructural logics in a cohesive fashion, taking into account these three distinct yet complementary points of view. The main momentum for this endeavour is provided by recent surprising results that confirm how deeply algebraic and proof theoretic methods are linked to one another. The proposal gathers leading experts in all these three areas, from all around the word, with the aim of reuniting these traditions and their communities and obtain deep results in all three areas. We are confident that this innovative, combined perspective on substructural logics will have a deep impact on the field and that this project will provide a stable basis of cooperation for a large, international community of algebraists, logicians and theoretical computer scientists, giving fresh impetus to these disciplines to flourish and integrate.

Keywords: substructural logics,residuated lattices,proof theory,algebraic proof theory,many valued logics,residuated structures,mv algebras,l groups,cut elimination,join completions,residuated frames
Extreme nonlinear dynamics of driven superconductors (SUPERDYN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-15
End date: 2022-12-14
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Due to very long energy relaxation times and strong non-linearities superconductors are the workhorse of many solid state quantum technologies. Previous studies have shown that a periodically excited superconductor can be taken to a new highly-nonlinear regime where quasiparticles perform synchronous collective Rabi oscillations. SUPERDYN will address all the challenges to observe these and similar highly nonlinear states in experiments. In particular, we will analyse thermalization process beyond a mean-field dynamics i.e. taking into account the effect of the environment, residual interactions and disorder. Results obtained with non-equilibrium diagrammatic techniques (Keldysh) will be validated comparing with computations within non-equilibrium dynamical mean-field theory (DMFT). Both the transient nonlinearities and the steady-state nonlinearities will be studied. In the latter case we expect typical effects of nonlinear quantum optics as induced transparency. A microwave device will be designed to measure these effects. This will require developing beyond state-of-the-art software and techniques to treat quasiparticle excitations and low-energy plasma modes on an equal footing. We will also develop a new variational method to obtain optimum driving protocols to obtain a desired transient superconducting state. The project will benefit from the synergies with various experimental groups. Secondments in a leading DMFT group and a leading experimental group developing quantum devices will complement the formation. The Experienced Researcher will be taken to a leadership position in the field of nonequilibrium superconductivity and solid-state quantum technologies with excellent future career prospects.

Keywords: out of equilibrium systems,dynamical systems,thz technologies,microwave technologies
Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht (RESCUE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 6069120.0
EU funding (EUR): 3034560.0
Participants: 1
Project status: SIGNED

With an aging population, a growing burden of chronic conditions, and rising healthcare costs in Europe, the need for organs, tissues, and personalized strategies for decision making in therapeutic choices has never been greater. Recent developments herald the promise of regenerative medicine and stem cell (RMSC) technology. However, for RMSC to fully capture its potential, a synergistic and multidisciplinary effort remains necessary to achieve essential scientific breakthroughs. There is thus a high demand for an excellent graduate program that trains a new brand of researcher who will successfully bring RMSC technology from bench to bedside and back. Such a researcher understands the needs and demands that exist in the clinic, the strengths and limitations of RMSC technology and its ethical and regulatory aspects, and has the entrepreneurial spirit to push their discoveries towards new applications. Therefore, the University Medical Centre Utrecht (UMCU) has initiated the RMSC-dedicated doctoral training programme RESCUE. RESCUE features an international, interdisciplinary and inter sectoral approach to train 29 highly skilled Early Stage Researchers (ESRs) to become the future leaders in RMSC research and implementation of RMSC technology. RESCUE brings together 31 principal investigators that are renowned experts in their fields, have ample experience with supervising PhD students and leading successful research groups. RESCUE is tightly connected with multiple international academic and private partner organisations, each providing complementary research or training. RESCUE enables UMCU to develop best practices in high quality training and research. The long-term ambition of RESCUE is to establish a strong and coherent network that connects highly skilled young researchers as well as established scientists, who will continue to inspire each other to excel in making discoveries in RMSC far beyond the funding period.

Keywords: regenerative medicine,stem cells,translational research,doctoral training
Molecular basis of the cross-talk between chronic inflammation and cancer (CrIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-03-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Cancer related inflammation (CRI) is a well-established hallmark of cancer. We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses. Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects of the immune system, resulting from increased pro-inflammatory cytokine levels and progressive bone marrow failure. Within this proposal, using SLX4-deficiency as a working model, I aim at investigating the molecular process underlying CRI. Based on our previous observation that the SLX4 complex binds to HIV-derived reverse-transcripts and promotes their degradation, my working hypothesis is that CRI results from the accumulation of endogenous pathological nucleic acids that are recognized by the innate immune system in the absence of SLX4. The present project should unveil the relationship between repression of pro-inflammatory cytokine production by proteins involved in DNA repair, DNA damage, and CRI, thereby opening unforeseen perspectives in the treatment of cancer patients.

Keywords: dna damage response,pathological nucleic acids,chronic inflammation,cancer
Safety-ENhancing Innovations for Older Road userS (SENIORS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Italy,Germany,Sweden,United Kingdom
Call: Traffic safety analysis and integrated approach towards the safety of Vulnerable Road Users (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2885587.26
EU funding (EUR): 2885587.26
Participants: 10
Project status: CLOSED

European countries face great challenges because the demographic structure in the EU is changing rapidly, due to reducing birth rates and increasing life expectancies. In 2012, 17% of Europeans were aged 65 and older and in 2020 this will rise to 28%. Meanwhile, the mobility needs of the elderly are also changing. Maintaining a driver's licence is an important issue of independence today, both for males and females. Also technological developments like the introduction of e-bikes enables access to other means of transport. These demographic and behavioural changes are of growing concern to mobility and road safety. While accident data show a decreasing number of fatalities and serious injuries on EU roads, recent data from the ERSO show an increasing proportion of elderly in the fatality statistics. This trend is a serious threat to the achievements of recent decades and poses a challenge that must be addressed to meet goals set for further reduction of road fatalities. Furthermore, there is an increasing rate of obesity in EU populations, which introduces changes in injury patterns and risks. The SENIORS project focuses on the protection of elderly and obese road users also by transferring nowadays younger generations’ safety standards. The objective is to develop the required understanding of accident scenarios, injury mechanisms and risks and to implement these findings in test tools and test and assessment procedures. An integrated approach considering the elderly in multiple transport modes is applied to reduce the portion of elderly fatalities. The small-scale project focuses on providing tools to encourage wider adoption of advanced restraint and pedestrian protection systems improving the protection of older and obese vulnerable road users. The activities consolidate results from previous EU projects such as THORAX and AsPeCSS and meet the needs defined by the GRSP IWG on Frontal Impact working on a near-term (2015) and mid-term (2020) update of UN-R94.

Keywords: integrated approach,safe mobility of elderly road users,consideration of all road transport modes,improved test and assessment procedures based on real world relevance
Flow Chemistry for C-H Activation (FlowAct)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The metal-catalysed group-directed functionalisation of C-H bonds is emerging as an important synthetic methodology in organic chemistry. Despite the advances in the field, however, C-H functionalisation processes are still plagued by several disadvantages, such as selectivity and reproducibility issues, the necessity of directing-group (DG) introduction, and the often difficult DG cleavage. This proposal combines the development of novel chemical transformations with the use of flow microreactors to: 1)make the DG introduction and cleavage more efficient and synthetically useful, and 2) make the C-H functionalisation processes more selective and atom economic, thus addressing several important weaknesses of this type of chemistry. After the development of the individual transformations in continuous-flow, the three crucial steps (DG introduction, group-directed C-H functionalisation and DG cleavage) will be integrated in a combined, multistep protocol, with the aim of minimising purification steps, and ultimately provide a cleaner and faster synthesis of functionalised molecules in a single continuous process.

Keywords: flow chemistry,c h functionalisation,microreactors