Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MOnitorIng water Status beyond the Tree scale: new tools for forest health assessment (MOIST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Increasing droughts reduce the water stored in trees leading to widespread forest mortality and higher fire risk. To know where and when forests are endangered, it is crucial to regularly monitor their water status at large (plot to regional) scales. However, there is a large information scale gap between the current measures of water status at the tree level and the target larger scales. Remote sensing retrievals of vegetation optical depth (VOD) can bridge this gap. The VOD is a parameter retrieved using global navigation satellite systems transmissometry (at plot scale) and satellite radiometry (at up to global scale). Recent research shows how water information can be isolated from VOD, and points to the application of different microwave frequencies to sense water in different tree tissues. In MOIST, VOD at plot and regional scales will be compared to in situ leaf and stem ecophysiological data. The VOD will be used to estimate water content in leaves and stems. Then, ecosystem-scale pressure volume curves, a novel concept in plant ecophysiology, will be applied to retrieve water potential estimates at plot and regional scales for the first time. Results will be provided to fire and forestry administrations to enhance their assessment of drought risks on forests. MOIST will combine remote sensing and ecophysiology, involve an international network of researchers, and work with a supervisor and a research center who are world-leading experts in forest ecophysiology. MOIST will reach international publics and engage young generations in taking care of forests. The applicant, Dr. David Chaparro, has the ideal remote sensing skills and dissemination experience to undertake this project, which is also perfectly designed to expand his skills, leveraging his career. With novel approaches to monitor the forests’ water status at large scales, MOIST will bridge the water information scale gap and provide unprecedented tools to assess forest conditions and risks.

Keywords: microwave remote sensing,vegetation optical depth,plant ecophysiology,water content,water potential,satellites,gnss transmissometry,forest mortality,fire risk
Mechanisms of Antibiotic Recalcitrance in ESKAPE pathogens (MAREE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

Antimicrobial resistance (AMR) is the silent pandemic uprising for the past decades that challenges practitioners to everyday life. In this context, more and more infections have become harder to treat, even in absence of genetic markers for AMR. This phenomenon, called recalcitrance, is related to the ability of susceptible bacteria to overcome antibiotic treatment and to reinitiate infection contributing to antibiotic failures and resistance emergence. Previous studies have described the involvement of a phenotypic switch leading to recalcitrance but underlying mechanism remain poorly understood. ESKAPE (standing for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) pathogens are the most prevalent causative agents in common recurrent healthcare-associated infections as well as well-known for their multidrug resistant phenotype and are the best candidates to understand recalcitrance. Hereby, we propose to investigate two of them, E. faecium (Efm) and E. cloacae complex (Ecc) by studying the proteome involved in recalcitrance. To identify any protein and/or pathway of interest, we will (i) identify which stress and bactericidal antibiotic induce recalcitrance both in Efm and Ecc; (ii) evaluate proteome and phosphoproteome of isolated antibiotic-recalcitrant bacteria; and (iii) confirm functionality of candidate proteins/pathways by mutagenesis and phenotypic approaches (in vitro and in cellulo) with the expertise of Prof. Helaine at Harvard Medical School (HMS) in Boston (secondment). Finding potential protein targets can highlight new candidates to further develop new therapies to overcome the rising of AMR.

Keywords: mass spectrometry,recalcitrance,eskape pathogens,antibiotic resistance
Enhancing the conversion of 'power to ethylene' through developing surface oriented catalysts (PEEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,United States,Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 225868.4
EU funding (EUR): 225868.4
Participants: 3
Project status: CLOSED

Ethylene, as a key building block in the chemical industry, has large market demand. Currently, the dominant production route is steam cracking of ethane, which is a highly endothermic and carbon intensive process. Proton ceramic electrochemical cells (PCECs) can selectively remove hydrogen from the reaction system, thus breaking the thermodynamic equilibrium limitation. In this project, the improved PCECs equipped with high-performance anodes catalysts will be used as environmental-friendly, efficient, and reliable way to co-produce ethylene and hydrogen from ethane at low temperature (400-550 C), demonstrating ethane conversion not less than 50% and ethylene selectivity not less than 80%. Here, we will combine hydrothermal synthesis and in-situ grown nanoparticles from matrix crystal lattice to develop the nanocatalyst with the specific surface facet and meta-oxide interface. The research tasks will be distributed into 6 work packages (WPs). In WP1, We will use hydrothermal synthesis to prepare nanocatalysts with specific surface orientation and in-situ growth of metal nanoparticles from the pre-doped matrix crystal lattice to form a special anchored interface structure, improving the stability and efficiency of the catalysts. In WP2, we will integrate the well-defined catalysts into the halfcells with the BaCe0.7Zr0.1Y0.1Yb0.1O3 anode backbone through infiltration. In WP3, the ethane conversion and ethylene selectivity of the PCEC will be characterized by gas chromatography supported with electrochemical characterizations. In WP4, DFT calculations in combination with surface characterization will be conducted to explore the reaction mechanism of ethane dehydrogenation at the anode. In WP5, we will cooperate with other laboratories for discussion and advice. In WP6, we will disseminate our results in time to expand the impact.

Keywords: power to ethylene,proton conducting electrolysis cells,surface orientation,in situ growing
Shaping the Future of Cloud for the Next Era of Computing (CloudNG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499001.0
EU funding (EUR): 1499001.0
Participants: 1
Project status: SIGNED

Datacenters are evolving fast allowing ultra-low latency, high bandwidth, and more programmability, while introducing new interconnects that radically change how we build distributed systems. Datacenters primarily host two types of workloads: cloud computing and bespoke applications. Cloud computing offers on-demand and elastic access to shared compute, networking, and storage resources, is ubiquitous and growing at an exponential pace. Bespoke datacenter applications, such as websearch, are special-purpose services developed and deployed by tech companies. There is a dichotomy between those two types of workloads regarding the evolution of the datacenter software and hardware ecosystem, with bespoke applications fully adopting recent advancements, while cloud computing only evolving incrementally and failing to absorb new hardware and protocols. This is due to fundamental differences between the two settings, and design choices in the existing cloud architecture and the way it has evolved, which end up harming efficiency, reducing the performance and quality of service cloud tenants receive, and slowing down cloud evolution. CLOUDNG designs the next generation of cloud infrastructure to fully leverage the modern datacenter. It accelerates and introduces novel abstractions that encapsulate emerging hardware and protocols without exposing their internals, and offers quality of service equivalent to bespoke applications without compromising ease of use. It re-envisions the cloud architecture and proposes new ways to implement resource allocation and elasticity by specifically designing for the datacenter environment, thus enabling superior performance, performance predictability, new cloud products, and measurable sustainability through appropriate metrics and incentives, while preparing the cloud for a new hardware era. This is an ambitious project pushing the state of the art in cloud and datacenter research, yet, a necessary step towards future cloud innovation.

Keywords: cloud computing,datacenters
Archives in Times of War: Scattered Families and Vanishing Past in Contemporary Syria (ARCHIVWAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 256442.88
EU funding (EUR): 256442.88
Participants: 3
Project status: SIGNED

Wartime Syria questions conventional understandings of the archive as a physical repository of documents and set of institutional practices. While Syrian state archives have fallen victim to destruction and plundering, Syrians in the diaspora have been saving and retrieving copies of mundane legal documents originally stored in state repositories as these documents are official proof of legal identities, education and relations to kin. These papers are fundamental in any migratory project since they are needed for numerous procedures, such as getting married. These documents are also central in preserving a connection to family members in Syria and in the diaspora. ARCHIVWAR examines these papers’ ubiquity, so far undetected in the study of the Syrian predicament, and the dislocation of state archives in private repositories to rethink the concept of the archive as a form of care. By examining family archives within the Syrian diaspora in Berlin, the action first aims to capture the modes of care and the relations to affective and physical presences and absences stored in these documents. Second, the project aims to make accessible a collective history-in-the-making about the Syrian predicament in Europe. Built upon the skills and experiences I have acquired along my research path, the action combines ethnographic methods with oral history research while employing an innovative format of engaged public scholarship. The project blends open science practices with immersive collaboration with the research participants to consolidate European society’s scientific literacy on wartime Syria and its long-lasting effects in Europe. ARCHIVWAR aims to contribute to the study of war and migration as well as of the archive and alternative forms of knowledge production, but as well widen my knowledge and skills in the field of Social Anthropology, Migration Studies, curatorship and and open access practices to complete my maturation as an engaged social scientist.

Keywords: archive,legal documents,history,transnational family,care,wartime,syria,exhibition
In-cell Redox Catalysis by Co(III) Metallodrugs as New Tools for Cancer Treatments (Co-CaReD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-28
End date: 2026-08-27
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The search of new therapies for cancer is a primary EU mission. In-cell redox catalysis promoted by organometallic complexes of precious metals as Ru(II), Os(II), Rh(III) and Ir(III) is a novel promising concept to access more efficient, safer, and less invasive medicines. Co-CaReD aims to design new in-cell catalytic systems based on half-sandwich Co(III) complexes. Cobalt combines effective catalytic performances for biomedical applications and high catalytic versatility. Moreover, it is a cheap, sustainable, and biocompatible metal whose peculiar chemical properties can access unique reactivity pathways. The project will focus on the development of new synthetic catalysts, on their applications in redox reactions of therapeutic interest, involving known examples and unprecedent cases of study, and on the unveiling of their biological mechanism of action in cancer cells. Co-CaReD will be implemented in a vibrant and stimulating research environment at IMDEA Nanociencia, in Dr. Ana Pizarro research group. The project will benefit of the complementary expertise of the ER in organometallic chemistry and redox catalysis and of the supervisor in studying the intracellular reactivity at the molecular level of metal-based drugs. An intense training plan is designed to equip the researcher with the necessary skills to study the biological activity of the Co(III) catalysts – including single-cell studies – and to design proof-of-concept experiments that confirm the occurrence of a metal-based catalytic reactivity inside the human cells. The main goal of Co-CaReD is to generate novel redox catalytic systems based on more biocompatible, less toxic, and cheaper cobalt drug candidates, as complementary tools to noble metal complexes.

Keywords: bioorganometallic chemistry,cisplatin,metallodrugs,bioinorganic chemistry
Unravelling the molecular evolution of plant-microbiome interactions in drylands (DryCoAdapt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1499325.0
EU funding (EUR): 1499325.0
Participants: 1
Project status: SIGNED

How plants evolved to shape their microbiota is a long-standing question in ecology and evolution. I posit that the microbiome forms a crucial part of how plants adapt to changing environments and that this microbiota optimization should be manifested in a strong genomic and phenotypic signature of adaptation. I propose to use natural plant variation and biogeography to dissect how plants evolved along with their microbiota to cope with aridity. Eight within-genus pairs of Brassicaceae species have been identified, distributed vicariously across a steep precipitation gradient. These species pairs represent eight independent instances of adaptation to aridity. This natural distribution offers an excellent framework for studying the evolution of plant-microbe interactions under arid conditions. My team will carry out an eco-evolutionary common garden experiment to compare the microbiomes of all 16 of these species under drought stress. By combining this experimental design with microbiome de-construction and gene deletion experiments, my lab will (i) test the hypothesis that microbially-induced drought resistance in plants is an evolutionary trait encoded in plant genomes (ii) identify the mechanisms that bacteria employ to protect plants from drought, and desert plants employ to attract beneficial bacteria. The sessility of plants dictates a particularly strong need for microbiota optimization in order to respond to a dynamic environment when there is no option to flee. Microbes are known to protect plants from drought stress, and plants are known to enrich particular microbes when stressed, but how these processes are linked remains unknown. This proposal is designed to establish this link by using our extensive knowledge on plant distribution to guide the study of the plant microbiome. Successful implementation will establish if and to what extent plants evolved to supplement their own genomes with those of their microbiota to cope with challenging environments.

Keywords: plant microbe interactions,drylands
Multi4 - the first surgical instrument for bladder cancer treatment through a 20-minute outpatient procedure (Multi4)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Sweden
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-08-01
End date: 2024-07-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Bladder Cancer (BC) is the 5th most common cancer in Europe with the incidence of 175.000 cases annually and has the highest lifetime treatment cost of all cancers. At the diagnostic step, a cystoscope is used. Usually, no biopsies are taken as there are no efficient methods to do so in the outpatient care. If the patient has suspected cancer seen on the monitor, they are scheduled for a surgery. At the surgery step, the biopsies are taken and the cancer is removed using a resectoscope. The procedure is difficult to perform. The instrument used is hard (metal, up to 12 mm in diameter) and inflexible (can damage the urethra). There is a high risk of cancer reseeding elsewhere in the bladder. Up to 75 % of BC patients relapse within 5 years. The related costs in the EU are estimated at € 5 billion annually. No development has taken place since the 1960 when the existing instruments were developed. We have developed and patented the first medical device (called Multi4) which allows for local treatment of BC through flexible cystoscopy during one visit to the urologist. The instrument has 4 functions: 1. Inject local anaesthesia through a thin needle 2. Pieces of the cancer are cut by the specially coated forceps. Bleeding is stopped immediately. 3. The cancer tissue is automatically transported out through the instrument itself. 4. When the forceps are closed, they become a burning electrode used to burn the surface where the cancer was located and ensure that all cancer cells have been killed. With the Multi4 platform, the patient can have their cancer treated at the first visit to the urologist. The procedure takes 20 minutes. This technology can thus disrupt the existing healthcare pathways where BC is treated through expensive and complicated surgeries. The proposed project will develop a go-to-market strategy for this ground-breaking deep tech innovation and empower the female founder to scale the company.

Keywords: bladder cancer,med tech,surgical instrumentation,endoscopy instrumentation,medical devices,market access strategy
Changing landscapes: hormonal fluctuations and neurocognitive functioning across the female lifespan (ChangingLandscapes)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Puberty, menstrual cycle, and menopause are all critical periods in a female’s life characterized by drastic changes in sex hormone concentrations. These periods are also associated with changes in cognitive, affective and social processing as well as an increased risk of depression and anxiety, stressing the need to advance our understanding of effects of hormonal fluctuations on females’ well-being across the lifespan. A central process directly associated with cognitive, affective, and social functioning is performance monitoring. Adequate processing of errors, reward, and feedback is essential for efficiently adapting to a changing environment in everyday life. Gender and age effects exist for these processes and disturbances have been linked to anxiety and depression, making performance monitoring an important topic in the investigation of neurocognitive functioning across the lifespan. However, research so far has largely ignored the effects of fluctuating hormonal levels. To answer the outstanding question how changing hormonal concentrations affect neurocognitive functioning in women, I will employ a unique multi-disciplinary methodology combining longitudinal, psychopharmacological, and neuroimaging techniques. I will address the current gaps in our knowledge using a novel combination of three approaches: (1) a lifespan approach that includes female participants from late childhood to late adulthood, (2) a social approach that moves beyond the non-social focus of performance-monitoring research, and (3) a psychopharmacological approach that focuses on the interactions between the relevant exogenous and endogenous neurotransmitters and hormones for the first time. The project represents a turning point in our understanding of the effects of naturally occurring hormonal variations on processes that are central for healthy cognitive, affective and social functioning, and will thus change the landscape of neurocognitive research relating to females of all ages.

Keywords: performance monitoring,female lifespan,estradiol,puberty,menstrual cycle,menopause,social cognition,electroencephalography,dopamine,oxytocin