Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PROMoting youth Involvement and Social Engagement: Opportunities and challenges for 'conflicted' young people across Europe (PROMISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Estonia,Germany,Italy,Croatia,Slovakia,Russian Federation,Finland,Portugal,United Kingdom
Call: The young as a driver of social change (H2020-YOUNG-SOCIETY-2015, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 2724107.5
EU funding (EUR): 2499107.25
Participants: 12
Project status: CLOSED

The challenges faced by young people across Europe have been the focus of public, political and academic debates at local, national and international levels. Young people face tough choices in key areas of social life that affect their participation in society, and their potential marginalisation from it: from structural issues of unemployment, lack of access to affordable housing and debt problems, to information overload on big questions like the environment, identity, faith and radicalisation, and negotiating the moral challenges of illegal markets and an increasingly sexualised social-media generation. While there are wide variations in opportunities and challenges between and within countries, young people today face tough choices in negotiating this moral maze. The PROMISE project will investigate how young people’s, often negative, responses to these problems create conflict, and how, instead, their responses can provide opportunities for positive social engagement. By addressing the experiences, values and attitudes of European youth seen to be in conflict with older generations, authorities and social norms PROMISE will get to the heart of barriers and opportunities for social engagement. We will employ a four pronged methodology to gather and analyse data (primary and secondary) on a cross-national level, alongside comparative ethnographic case study data that uniquely addresses the experiences of ‘conflicted’ youth within the context and social history of each country. Each case study will address a site of conflict and stigmatisation as a (potential) site of innovation or social change. Throughout the process, we will involve young people across Europe in setting the agenda, in documenting their situation and in articulating their needs. PROMISE will produce a comparative ethnography of young people in 10 European countries, a comparative quantitative analysis of attitudes, values and control, and policy papers and positive engagement strategies. For better communication the next acronyms are used in the proposal: UNIMAN (P1), IPRS (P2), CJD (P3), UAB (P4), UCP (P5), UMB (P6), FYRN (P7),UTARTU (P8), CYC (P9), IPI (P10), YES (P11), GESIS (P11)

Keywords: youth innovation,social exclusion,intergenerational conflict,stigmatization,opportunities for change
Real-time characterisation of neuropeptide binding to a membrane receptor involved in pain and ischemic stroke (hsPCF-FRET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Under physiological conditions, localized acidification of brain tissue serves as neuronal signal that get synaptically transduced via acid-sensing ion channels (ASIC1a). Local acidosis has, however, also been linked to some of the most prevalent neurological disorders such as chronic pain, ischemic stroke and psychiatric diseases. ASIC1a has thus emerged as drug target with great potential, but no drugs are currently available that specifically target the channels under pathological conditions. A few known neuropeptides modulate ASIC1a and could thus serve as scaffolds for a new generation of ASIC1a-selective drugs to, for example, treat pain without the typical downsides of opioids. Advances have, however, been hampered by the limited understanding of detailed protein-peptide interactions. Thus, the aim of the proposed project is to directly characterize the binding of the neuropeptide Big Dynorphin to ASIC1a in real time. Here, I will use a unique in-house developed high-sensitivity fluorescence patch-clamp electrophysiology setup and establish a protocol for a FRET-based ligand-binding assay. Together with site-directed mutagenesis, this approach will be able to identify state-dependent binding sites and key interactions, and allow direct analysis of binding affinity and kinetics under pathological conditions; all in intact membranes and with unprecedented (microsecond) temporal resolution. This information will aid future design of ASIC inhibitors with the potential to treat chronic pain and ischemia. The technology developed for this work will also enable ligand-binding studies of other membrane proteins in living cells and with high temporal resolution and will thus be of great potential value for a broad field. The project will expand my existing electrophysiology skills and add highly versatile expertise in fluorescent measurements. I thus anticipate my project to have significant personal and scientific impact beyond the scope of this proposal.

Keywords: acid sensing ion channels,electrophysiology,allosteric modulation,ligand binding,fret,high sensitivity patch clamp fluorometry,neuropeptide,dynorphins,chronic pain,ischemic stroke
Voltage Nanosensors for Applications in Neuroscience (NiSAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-11-01
End date: 2019-04-30
Duration (months): 18.0
Total project cost (EUR): 149566.0
EU funding (EUR): 149566.0
Participants: 1
Project status: CLOSED

To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift , fast temporal response, minimal photobleaching, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. In this PoC proposal we seek to convert the NVS program from mainly “R” in R&D effort into “D” effort which will allow for IP protection, commercialization, dissemination, and therefore the ‘democratization’ of the technology to the large community of neuroscientists. In order to convert our achievement to commercially viable reagents business for the neuroscience community via the PoC program, we will (i) identify leading applications in neuroscience and brain research, (ii) improve current technology to meet the applications demands by fine tuning the control over size and shape of the particle and testing various types of coating, testing insertion into different lipid compositions in bilayers and cells, and by testing non-specific internalization, (iii) improve the stability and performance reproducibility of the sensors, (iv) develop methods for upscaling the synthesis of these NPs, (v) and formulate GLP protocols required for commercialization. Upon achievement of these goals, we will obtain a versatile, stable, multipurpose, novel tool to be implemented in neuroscience.

Keywords: electrophysiology,neurobiology,single molecule spectroscopy,physical chemistry,analytical chemistry,method development in chemistry,optical recording,bioelectronics,electroceuticals
Modelling the transfer of long-term temperature changes in the atmosphere to the vadose zone of karst regions: from glacial cycles to the ongoing global warming (MOTKA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Karst covers approximately 20% of land on Earth, and most caves are in these regions. Temperature records of most caves in the vadose zone (above the phreatic level) have a limited variability through the year and its value is close to the mean annual temperature of the atmosphere above the cave. This thermal coupling is the result of the atmospheric thermal signal being transferred underground by conduction and its anomalies being attenuated and delayed with depth. However, during persistent climate changes, cave and external atmosphere temperatures are temporarily decoupled. The change in cave temperatures (and in the full vadose zone) has major implications for numerous disciplines: ecology of underground environments, conservation of cave art, endurance/formation of ice in alpine caves or in permafrost regions, geochemistry of groundwater and paleoclimate records of speleothems, and also climate change because of the radiation of ground heat to the atmosphere. Experimental studies in karst regions already confirmed that thermal conduction models reproduce the cave temperature of past decades. So, the MOTKA proposal aims to simulate the temperature of caves during long-term climate changes using thermal conduction models, as well as to study the consequences of those changes in one particular discipline: paleoclimate d18O records from speleothems. Our integrated view of ocean paleoclimate records and cave environments is pioneer and enables to simulate past cave temperature records. The MOTKA proposal will apply for the first time thermal models to long-term climate changes, including glacial cycles, millennial oscillations, the ongoing global warming and its projection into the future. The simulations of this research will add a temporal dimension to the complex dynamics in underground environments. As an applied example, MOTKA proposal will explore the impact of thermal decoupling in the paleoclimate interpretation of speleothem d18O records.

Keywords: modelling,thermal conduction,caves,glacial cycle,global warming,speleothem records
Novel use of exon skipping technology to study structure-function relationship of dystrophin (DYS_FUNCTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Duchenne muscular dystrophy (DMD) stems from loss of dystrophin in skeletal and cardiac muscles, which leads to loss of ambulation and cardio-respiratory failure. The most promising treatment that could be applicable to 83% of DMD patients is exon skipping, a technology where the EU is a world leader. Antisense oligonucleotide mediated exon skipping targets DMD pre-mRNA to induce skipping of specific exons and restore the open reading frame. This allows expression of shorter dystrophin proteins that lack domains encoded by the skipped exon(s). A crucial question is how to predict which short dystrophins will be stable and functional. This knowledge is fundamental to select DMD patients that would most benefit from this treatment and identify exons worth targeting via exon skipping. The goal of this proposal is to develop a new use of exon skipping technology to rapidly generate mouse models to screen short dystrophins for in vivo stability and functionality in both skeletal and cardiac muscles. This is made possible by a new exon skipping chemistry developed in the UK with unparalleled skipping efficiency in vivo and capable of targeting the heart. I will use this technology to create mouse models for two short dystrophins generated in DMD patients undergoing exon 51 skipping in the current UK clinical trial. I will then biochemically assess their stability and functionality in limb, cardiac and respiratory muscles. Parallel histological studies will assess the presence of muscle pathology with a focus on heart and diaphragm that cannot be sampled in DMD patients. This project will serve as a trampoline for future studies to identify dystrophin exons that when skipped will produce functional proteins with clinical benefits. In addition, this research will generate new fundamental knowledge on dystrophin domains critical for muscle function and may help in the prognosis of DMD patients currently undergoing exon 51 skipping.

Keywords: exon skipping,muscular dystrophy
DEMOTEC - Democratising Territorial Cohesion: Experimenting with deliberative citizen engagement and participatory budgeting in European regional and urban policies (DEMOTEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Cyprus,Poland,Romania,Belgium,Netherlands,Netherlands,United Kingdom
Call: Developing deliberative and participatory democracies through experimentation (H2020-SC6-GOVERNANCE-2020, 2020)
Start date: 2021-03-01
End date: 2024-02-29
Duration (months): 36.0
Total project cost (EUR): 2827546.25
EU funding (EUR): 2827546.25
Participants: 7
Project status: SIGNED

DEMOTEC investigates the role of participatory budgeting in fostering greater and more informed citizen participation in policy-making and in engaging citizens that feel disconnected from political and policy processes. It focuses on citizen engagement in European regional and urban policies, combining in-depth research on participatory budgeting and mediated deliberation in the public sphere with real-world experiments. DEMOTEC will apply innovative methods in seven urban authorities from across Europe, including experiments, deliberative polling, computational text analysis of big data, representative surveys, framing and discourse analysis and case studies. It will provide novel theoretical and empirical findings on participatory budgeting and democratic decision-making, develop practical tools and capacity for practitioners, and produce timely policy recommendations at different government scales. DEMOTEC consists of an interdisciplinary and well-integrated consortium of academic, media and citizen engagement partners with expertise in political science, regional and urban studies, sociology, psychology, media and communication studies, and computer science. The Consortium places strong emphasis on the co-creation of democratic innovation and knowledge with policymakers and communication with a variety of stakeholders throughout the project, including public authorities at all territorial levels, journalists, civil society organisations and the general public.

Keywords: participatory budgeting,eu cohesion policy,urban policy
OPENING THE PATHWAY TOWARDS DENDRITIC ZEOLITES (TODENZE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2378438.0
EU funding (EUR): 2378438.0
Participants: 1
Project status: SIGNED

A great interest has arisen in the past ten years on synthetic materials exhibiting a dendritic 3D superstructure due to their outstanding and singular properties and to the high number of potential applications in a variety of relevant fields. Starting from silica nanoparticles, dendritic structures have now been extended to other compositions. However, the development of dendritic zeolites has remained elusive in spite of their huge scientific and industrial relevance. Being considered mature materials, the reality is that the scientific publications on zeolites is constantly and rapidly growing. Thus, over 48,000 articles can be found in literature databases by 2020 including the term “zeolite” in the title, with about 2,370 contributions just in 2020. However, almost no records are found when the term “dendritic” is added to the search. In this context, I have envisaged TODENZE as a very ambitious and high-risk project aimed to develop a general strategy for the synthesis of zeolites with dendritic 3D superstructures. The achievement of this goal will have a strong impact in the scientific community working with porous solids and also in many other fields and topics in which dendritic zeolites are expected to exhibit a quite better performance than the state-of-the-art zeolitic materials. Starting from preliminary results of my research group, I have structured the TODENZE project according to 4 major objectives in relation to the concept of dendritic zeolites: i) Unveiling the synthesis mechanism; ii) Expanding and generalizing the concept, iii) Assessing the properties, and iv) Finding relevant applications. In particular, their use as catalysts for biomass valorisation and as nanocarriers for combined drug/gene therapy will be explored. Achievement of the TODENZE goals will provide remarkable benefits and high-gains in strategic areas such as environment, sustainable energy, circular economy and health.

Keywords: zeolites,dentritic materials,catalysis,biomass valorisation,drug delivery,crystallization
Advanced Manufacturing assistance and training for SME Transformation (ADMA TranS4MErs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Austria,Estonia,Ireland,Italy,Malta,Cyprus,Belgium,Poland,Romania,Slovenia,Lithuania,Romania,Sweden,Sweden,Sweden,Finland,Hungary,Bulgaria,Greece,Croatia,Slovakia,Latvia,France,Czechia,Netherlands,Denmark,Luxembourg,Denmark,United Kingdom,Portugal
Call: Pan-European advanced manufacturing assistance and training for SMEs (H2020-INNOSUP-2020-08, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 5623188.88
EU funding (EUR): 5623188.63
Participants: 41
Project status: SIGNED

The ADMA TranS4MErs will accelerate factories to become Factories of the Future embracing the ecological, digital, and societal challenges. This will be done via a smart combination of an all-connecting community platform in combination with toolboxes, virtual and physical training activities, assistance programs, tailor-made training content in all relevant technology areas and set of applications. All those services, tools, assistance, and service components pick up the SMEs at the right stage to start their own Trans4mation journey. The consortium is equipped with all necessary experience and professionalism and has a wide geographical reach, that we can almost guarantee to deliver the services at their doorstep or on their screen.

Keywords: smes,advanced manufacturing assistance and training for sme transformation
Exploring MIcrobial networking in pesticides biodeGRAdaTion: novel inocula and biocatalysts for biodepuration of agro-industrial Effluents (EMIGRATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 152653.2
EU funding (EUR): 152653.2
Participants: 1
Project status: CLOSED

Pesticides constitute priority pollutants for natural resources. Microbes, mostly in the form of microbial consortia are pivotal in the in situ pesticide biodegradation. EMIGRATE aims to investigate the complex interactions driving the coherence and biodegradation capacity of natural bacterial consortia, and through this, enable the production of biotechnological and bioengineering tools for novel environmental clean-up strategies. A microbial consortium degrading the fungicide thiabendazole used in fruit-packaging plants will be used as a model. This choice is based on the high biotechnological potential of this consortium considering the environmental risk associated with the use pattern, recalcitrance and toxicity of this fungicide and the complete lack of information regarding its microbial metabolism. Through its innovative research EMIGRATE will facilitate the re-integration of the fellow to the local and EU research community. Project's objectives will be achieved through 7 work-packages: WP1 will deal with project management, IPR and results exploitation, WP2 will focus on fellow's training and WP3 on the dissemination and public engagement of project's findings. WP4 will focus on the in-depth phylogenetic characterization of the bacterial consortium and the identification of the roles of consortium members on pesticide metabolism (Stable Isotope Probing - amplicon sequencing). WP5 will assign wider functional roles to consortium members, identify key catabolic genes and elucidate the metabolic pathway of the fungicide via a meta-genomics, -transcriptomics, -metabolomics approach. Finally, WP6 and WP7 will exploit the bacterial consortium for isolation of novel enzymes-biocatalysts and the development of an innovative biological process for the depuration of the relevant agro-industrial effluents. Secondments to academic and industrial partners will be carried out for skill development of the fellow on isotopic techniques, metabolomics and bioengineering.

Keywords: pesticides microbial degradation,microbial consortia,agro industrial effluents,biodepuration,metagenomics,metatranscriptomics,metabolomics,metabolic pathways,stable isotope probing