Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dendro-somatic Coupling and global neuronal signaling (Cortical Coupling)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany,Greece
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

The mechanism for anaesthesia has eluded neuroscience despite being used as a medical intervention for more than two centuries. Two facts are clear: loss-of-consciousness under anaesthesia correlates with a massive reduction in global neuronal signalling and a de-coupling of feedback information. We recently found that the apical dendrites of layer 5 pyramidal neurons are effectively "cut off" from the cell body under anaesthesia and that higher order thalamic input maintains dendro-somatic coupling via the activation of metabotropic glutamate and acetylcholine receptors. We hypothesize that dendro-somatic coupling, the influence of the apical dendrite on the soma, regulates the flow of information around the brain. If true, this would mean that dendro-thalamic coupling is a ubiquitous mechanism by which the brain, via thalamo-cortical interactions, can regulate the degree to which feedback is reintegrated into any given cortical column. Moreover, since human pyramidal neurons are twice as long as rodent neurons, the issue of dendro-somatic coupling in human neurons is even more profound. Here, we propose to comprehensively investigate this cortical coupling mechanism in vitro and in vivo using state-of-the-art approaches developed in my laboratory and specifically designed to investigate dendritic signalling. We will also perform experiments in resected cortical tissue from human patients using fast-viral expression of optogenetic constructs, an approach that we have also developed and tested in my laboratory. Lastly, we use modelling to probe the consequences of dendro-somatic coupling both for single-cell computation and the principles of multi-compartment neuronal networks. Dendro-somatic coupling as a dynamic mechanism for global neuronal signalling is a bold new perspective for which we have clear evidence, and which stands to revolutionize our understanding of cortex and possibly also provide insights into more efficient neural network architectures.

Keywords: cerebral cortex,dendrites,anesthesia,metabotropic receptors
DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation (Vascular-Rhythm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1499705.0
EU funding (EUR): 1499705.0
Participants: 1
Project status: SIGNED

A quiescent, resilient layer of blood vessel-lining endothelial cells (ECs) is vital for maintaining organ function and enabling healthy aging. Much has been learnt in recent years about the mechanisms controlling the resilient EC phenotype. In turn, little is known if and how mechanisms of vascular resilience are affected by environmental rhythmic stimuli (extrinsic (e.g., light-dark, feeding-fasting) or intrinsic (e.g., blood pressure, hematopoiesis)). Performing day/night analyses of mouse liver and lung ECs, we identified distinct organ-specific time-of-the-day dependent transcriptomic programs of resting ECs. These translated functionally into temporal vascular adaptations during the day that critically sustain steady-state tissue health and function. Building on these stage-setting findings, the Vascular-Rhythm project will (i) analyze how ECs sense, adapt, and respond to circadian changes by uncovering rhythmic programs in healthy liver and lung ECs at mRNA, protein, and phospho-protein levels, and (ii) examine how the manipulation of vascular rhythms impacts physiological organ function, organismic aging, and disease initiation. To this end, we will implement a cross-species analytical platform (i.e., comparing nocturnal mice and diurnal pigs), integrate multiomics data with state-of-the-art computational methods, and perform in vitro & in vivo manipulatory assays to discover dynamic gene programs that underlie the homeostatic vascular endothelium and its adaptation to pathologic challenges. Collectively, adding the day/night cycle as a critical, hitherto in the field of vascular research heavily underappreciated research dimension, the Vascular-Rhythm project will fundamentally change the way we study and mechanistically understand blood vessel function. Moreover, the expected groundbreaking discoveries of the project have great potential to identify and validate novel therapeutic vascular vulnerabilities for multiple, circadian rhythm-affected pathologies.

Keywords: blood vessels,endothelial cells,capillary endothelium,liver sinusoidal endothelial cells,lung endothelium
Autonomous Full Farming for Optimised Regenerative and Wholesome Agriculture with Robotics and Deep-Learning (A-FORWARD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Renewable energy sources and their whole value chain including materials development and recycling of components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 3535635.0
EU funding (EUR): 2474944.5
Participants: 1
Project status: SIGNED

Nature Robots is a pioneering startup founded in 2022, spearheading a revolution in agriculture with its fully autonomous farming system, led by CEO Dr. Sebastian Pütz. Backed by €2.1 million in funding, the company aims to transform agriculture by reducing greenhouse gas emissions, enhancing biodiversity, and decentralizing food supply. Nature Robots aims to develop an autonomous full farming system that integrates resilient autonomous navigation technology with hardware robotics, operated from a base station, enabling farmers to implement regenerative practices and cut costs by up to 80%. With a team of around 10 professionals specializing in robotics, AI, software engineering, agriculture, and business development, supported by seasoned advisors, Nature Robots is poised to lead the way in scalable deep-tech solutions for vegetable farming. Their innovative system, comprising Autonomous Navigation, Weed and Crop Monitoring, Agronomic Planning, and Lero Robot & Implements, leverages AI and robotics to address the diverse needs of farmers in different climates and soils. Nature Robots' commitment to advancing regenerative agriculture through cutting-edge technology positions them as a leader in the field. In this EIC project, Nature Robots aims to request Blended Finance with €2.5M of grant financing and €4M equity financing. This enables Nature Robot to bring the full farming system to TRL8 and ensure scalability.

Keywords: regenerative agriculture,autonomous navigation,full farming system,regenerative farming,market garden,community support agriculture
Innovative New Strategies in Generating High-impact Chemical Transformations (INSIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Netherlands,Switzerland
Call: ERC SYNERGY GRANTS (ERC-2025-SyG, 2025)
Start date: 2026-04-01
End date: 2032-03-31
Duration (months): 72.0
Total project cost (EUR): 9984944.0
EU funding (EUR): 9984944.0
Participants: 3
Project status: SIGNED

Earth's growing population puts immense pressure on ecosystems due to increasing demands for natural resources, which are transformed into materials or energy for human use. Chemical catalysis is our primary tool for converting molecules, and advancements over the last century have made these processes more sustainable. While catalysis holds promise for addressing the urgent need for efficient, sustainable resource conversion, current discovery and optimization methods are too slow to meet global demands. The INSIGHT project, a collaboration between a synthetic chemist, mass spectrometry expert, and theoretical chemist, aims to accelerate this process. We are developing a workflow that rapidly generates knowledge in catalysis. Building on our discovery of adaptive dynamic catalysis, where the physical state of a metal ion is maintained in its active form by external stimuli (light or electrons), we integrate this approach with flow mass spectrometry. This enables us to explore an unprecedented number of parameter permutations, identify successful reactions, and gather kinetic data, which will inform theoretical models and provide deep insights into catalytic systems. Our project unfolds in three stages: First, we refine mass spectrometry techniques, generate data, and build models using well-established chemistry for cross-coupling carbon-halogen bonds. Next, we apply our discovery workflow to the underexplored area of carbon-oxygen bond activation, which holds significant potential for sustainable catalysis. Finally, we demonstrate the power of our method by tackling one of chemistry’s greatest challenges—carbon-carbon bond activation. By exploring a much larger chemical space for this transformation and using model-based knowledge generation, we aim to uncover innovative catalytic solutions that address some of the world’s most pressing resource challenges. This accelerated approach may revolutionize chemical catalysis, offering sustainable solutions.

Keywords: photoredox catalysis reaction monitoring in situ mass spectrometry
Improving the Economic and Environmental Outlook of the Beef Industry with Autonomous 3D Vision Technology (HerdAssist)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1886500.0
EU funding (EUR): 1886500.0
Participants: 1
Project status: SIGNED

Global demand for beef has doubled over the past 50 years and is predicted to continue growing in response to increasing population and the rising affluence of the developing world. Meeting this demand creates significant social, animal welfare and environmental pressures. Beef has by far the largest environmental footprint of any agrifood (100 kg CO2e / kg of meat produced), however efforts to reduce consumption or introduce replacements, e.g. Beyond Meat, have stalled. Minimising beef’s impact on emissions, land use, and deforestation is therefore an urgent priority, reflected by landmark policies like the EU’s Green Deal and Farm to Fork Strategy. Many producers are eager to reduce their impact but face existential threats from rising costs, globalisation and new regulations. As such, balancing conflicting environmental priorities against farmer livelihoods is currently an intractable industry problem. Improving the productivity of livestock producers will help to address these challenges. Growing cattle more efficiently – using less feed, time, and through better animal health – can dramatically reduce costs and environmental impacts. Unfortunately, producers simply do not have the tools available to achieve this today. Farmers need reliable, regular data to manage the growth (and thus productivity) of their herds, but industry still relies on costly, dangerous and inconsistent manual weighing and assessment methods which make it all but impossible to achieve this. Agsenze has developed the world’s first fully-automated 3D vision-system to safely and non-intrusively track cattle growth, condition and wellbeing. This provides regular, reliable insights which allow farmers to proactively manage the feed, welfare and genetic inputs of their herds. The HerdAssist project will build on our successful, farm-tested prototype to complete our development programme and enable the widespread commercialisation of our innovative system across all beef farms, worldwide.

Keywords: beef farming livestock management machine vision emissions reduction animal welfare farm productivity,supply chain fairness
Swapstation charging infrastructure and energy storage technology for clean urban mobility (SWAP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Swobbee aims to address the pressing need for sustainable urban clean charging solutions in response to escalating challenges posed by pollution and traffic congestion in cities worldwide. With traditional transportation methods heavily reliant on gasoline-powered vehicles, the environmental and economic toll of these practices has reached critical levels, necessitating urgent intervention. Our company introduces an innovative solution for urban charging and thereby addresses the pressing challenges of pollution and traffic congestion. Our unique service offers a comprehensive ecosystem for electric vehicle (EV) charging and battery swapping, tailored to meet the diverse needs of individual commuters, businesses, and city administrations. Our concept is based on the exchange of an exhausted battery with a fully charged equivalent. These systems are designed to streamline the recharging process of electric vehicles. Our novel smart charger for bi-directional charging of batteries integrates with the most batteries already in use. This plug-and-play system allows anyone to participate in energy trading using their existing batteries, often underutilised in this scenario. As we embark on our expansion journey, our sights are set on key European markets known for their commitment to sustainability. However, our vision extends encompassing the vast potential of the North American and Indian markets with combined total market value of 500bn USD projected in 2030.

Keywords: bi directional charger,battery station,swapping infrastructure,light electric vehicles,e mobility,energy trading
Microbiome-Microglia interaction in Alzheimer's disease (MiMi-AD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Alzheimer’s disease (AD) affects over 55 million people worldwide, with no effective treatments currently available. Understanding early-stage mechanisms of the disease is critical to developing new therapeutic approaches. Microglial cells, key regulators of amyloid-beta (Aβ) clearance and neuroinflammation, are implicated in the progression of AD. Emerging evidence suggests that the gut microbiota, through its influence on microglial function, may play a pivotal role in AD pathogenesis. However, the precise regulatory mechanisms of the gut-microbiota-brain axis in AD remain unexplored. The MiMi-AD project, aims to elucidate the role of gut microbiota in modulating microglial activity across AD progression stages, using the Tg2576 mouse model of AD. Specifically, the project will investigate whether exercise-induced alterations in gut microbiota can prime microglial cells to promote Aβ clearance, delay cognitive decline, and reduce neuroinflammation. The research will employ cutting-edge transcriptomics, metabolomics, and microbiota analysis to explore these dynamic interactions, along with in vivo and in vitro studies to identify targetable microbial metabolites. The outcomes of this research could identify novel gut-brain axis pathways, providing a foundation for therapeutic strategies aimed at delaying the onset of AD. Through interdisciplinary collaboration, this project aligns with European and global priorities in promoting healthy aging, offering potential benefits for individuals at risk of developing AD.

Keywords: microbiota gut brain axis,microglia,alzherimer s disease,neuroinflammation,hippocampus,exercise,multi omics,microbial metabolites,metagenomics
Regional Center of Excellence at the Orbeli Institute of Physiology (NAR-SAR-IPH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Armenia
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2415000.0
EU funding (EUR): 2415000.0
Participants: 1
Project status: SIGNED

Through the Horizon Europe ERA Chairs action program, we aim to enhance the research environment in the Orbeli Institute of Physiology (IPH), a major biomedical academic entity established over 75 years ago in Yerevan. With the help of the Horizon Europe ERA Chair action program, we aim to modify the research and innovation landscape within the Orbeli Institute of Physiology (IPH), a major academic entity established over 75 years ago in Yerevan, Armenia. Under the direction of the proposed ERA Chair, a new scientific direction is to be developed and a number of key structural changes within IPH are to be implemented. These include 1) establishing a regional research center with a focus on tissue engineering, 2) educating a new generation of junior researchers in modern methods and approaches to collect and analyze data, 3) improving the institute's research compliance environment, including setting up committees on animal and human subjects, 4) institute-wide training in grant writing and management. In addition, to achieve long-term sustainability of IPH research efforts, the ERA Chair holder aims to establish collaborations with regional medical centers with an ultimate goal to help to manufacture bioscaffolds & implantable biomimetic tissues as well as to establish protocols for testing and culturing patient-derived pluripotent stem cells. In addition to being one of the most exciting scientific fields of the 21st Century, tissue engineering and regenerative medicine represent a true bridge between academia and medicine which brings scientific discoveries to the realm of everyday life. Horizon Europe ERA Chair grant can enable the IPH to build upon its existing scientific arsenal and resources to achieve regional leadership in the field of tissue engineering and regenerative medicine, becoming a driving force for strengthening Armenia’s science base in a variety of disciplines, ranging from biology, physics, chemistry, nanotechnology, and biomedical engineering.

Keywords: hyperspectral analysis,tissue engineering,regenerative medicine,biomedical imaging,cell biophysics
2D TM-LDH (Layered double hydroxide) with low dimensions materials (MXene, graphene, and TMC) as flexible solid state and electrochemical supercapacitors and electrocatalyst. (TM-LDH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-11-01
End date: 2025-11-30
Duration (months): 25.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Two dimensional (2D) materials and their composites are now in trends due high electrocatalytic activity and ion storage capacity. The development of cost-effective and simple electrocatalyst for energy applications are still challenging. The best substitute to typical Transition metal oxides/hydroxides/chalcogenides (TMOs/TMHs/TMC) for electrocatalysis is Transition metal based Layer Double Hydroxide (TM-LDH). Layer Double Hydroxide materials have various benefits, including low cost, chemical composition variety, easily manipulated characteristics, a wide range of preparation variables, unique anion exchange and intercalation properties, chemical stability, and colloidal and thermal behaviour. But the fewer active sites and poor electronic conductivity of Layer Double Hydroxide restricts their applications. Here, the proposed work has the purpose to contribute to the expansion of electrocatalysts that are effective in a variety of energy applications. The main focus is to develop hierarchical structure of Layer Double Hydroxide, composition of Layer Double Hydroxide/Transition metal chalcogenides and Layer Double Hydroxide/carbon based materials adopting various methods such as hydrothermal/solvothermal, liquid phase exfoliation and electrodeposition. The technique appears to eliminate hurdles related to electrical/ionic conductivity and surface morphology, resulting in a bifunctional/trifunctional electrocatalyst that is effective for wearable supercapacitor and overall water splitting.

Keywords: layered double hydroxide,electrocatalyst,supercapacitor