Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Research Into Aeromechanical Solutions (ARIAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Germany,Spain,Italy,Spain,Belgium,Poland,Sweden,Sweden,Belgium,Sweden,France,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Maintaining industrial leadership in aeronautics (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 7657442.5
EU funding (EUR): 7503731.0
Participants: 27
Project status: SIGNED

The ARIAS research and innovation project directly targets “maintaining industrial leadership in aeronautics” of the European aircraft engine manufacturing sector in the important technology sub-area “development and validation of multi-disciplinary design tools that address key isolated or clustered industrial problems with low degree of confidence that need presently extensive experimental verification” by investigating aeromechanical phenomena (flutter and forced response) in three distinct sub-systems (compressor, low-pressure turbine and seals) of the aircraft engine. The interaction of these aeromechanical phenomena is not well characterised. This can lead to inefficient designs or unwanted blade vibration which can increase development time and costs and can ultimately lead to the failure of an engine during operation which can have fatal consequences (Kegworth 1989). Previous EU projects have treated forced response (ADTurB-1&2) and flutter (FUTURE) as isolated phenomena. They have delivered unique experimental data and testing of numerical models enabling industry to progress blade design and analysis. These projects also revealed the need for coupled flutter and forced response methods. ARIAS will provide deeper insight into aeromechanical technologies for more sophisticated and break-through coupled analyses, measurements and vibration mitigations. Beyond state-of-the-art methods that have never been used in blade or seal design, to assess aeromechanical vibrations will be used such as multimodal simulations and superimposition of flutter and forced response. Expected outcomes are a better understanding of flutter and forced response and the development of new higher fidelity analytical tools which will enable the design of more efficient and safer aircraft engines. The project will also contribute to a world-wide unique “MOOC-type” on-line learning material on aeromechanics, involving academic and industrial partners.

Keywords: flutter,forced response,aeroelasticity,aeromechanics
Integral cell-biology platform for the development of the first effective treatment of radiodermatitis. (SkinXCare)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

InnoHealth Group is a private company born with the mission of offering novel dermatological formulations, with a major focus on the rational development (scientific-based approach) of new and more effective therapeutic solutions to dermatological diseases. Our vision is to become a leading player of the therapeutic dermatology and skin care markets segments, something that will be enabled thanks to our patented cell biology platform for the development of novel products. Our platform is the only one in the market that integrates novel bioinformatic tools based on cellular proteomic/kinome data (SkinSim and INCOS) and in vitro assays (SimDerma) for the rational design and development of new dermatological formulations. The combination of these tools in the platform allows identifying the molecular/celular targets involved in skin diseases and the combinations of active ingredients/compounds with the highest synergistic activity in these targets for disease treatment. This makes our platform a key enabling technology for the development of new dermatological products, especially in treatment of skin diseases without a known efficient therapeutic solution because of the complexity in the cellular and biochemical damages underlying such diseases. In the SkinXCare project we seek demonstrating the potential of our platform by its use in the development of the first effective treatment of radiodermatitis, a severe skin condition that affects cancer patients undergoing radiotherapy and still remains an unmet clinical condition. Thanks to the uniqueness of the solution proposed in the SkinXCare project, we seek becoming a leading player of therapeutic dermatology market. This market segment was valued at €24.5 billion on 2015 and is predicted to grow at a CAGR of 6.7% until 2025, key figures that further sustain the SkinXCare business opportunity.

Keywords: dermatology,radiotherapy
The Aftermath of a Drug Withdrawal: Modeling Spillover Effects Across Countries and Across Categories (WITHDRAWAL AFTERMATH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The pharmaceutical market is one of the most important industries in the global economy. Projections are that spending on medicines will grow to 1.2 trillion US$ in 2016. Marketing has an important impact in this pharmaceutical industry, but has a particularly negative image. The growing pharmaceutical market increases the pressure for the regulators to approve new medicines and for firms the pressure to market their drugs to stay ahead of the competition. These forces have contributed to the fact that over the past decade many drugs were approved too early, and the number of withdrawn drugs has doubled. A drug withdrawal is when a drug is taken off the market, because it is considered to be harmful typically due to unexpected adverse effects (including deaths). Since the pharmaceutical market directly concerns population health, drug withdrawals can have disastrous consequences. While there has been some research done into the aftermath of a withdrawal from the perspective of the focal drug, very little research has been done on the spillover effects. This project is the first to explicitly focus on spillover effects in the aftermath of drug withdrawals. There are two types of spillover effects to consider (i) across drugs (Do doctors start prescribing the competing drug, or has the withdrawal a negative spillover effect?), and (ii) across countries (If a country lags in withdrawing a drug, does the withdrawal in leading countries spill over?). Advanced econometric techniques will be used to model the dynamics before and after withdrawals, including spillover effects and the dynamics between sales and marketing. Results of this project will not only benefit managers of pharmaceutical firms, but is also important from an economic (i.e. given the size of pharmaceutical market) and societal (i.e. the high profile nature of withdrawals and the role of government agencies) perspective.

Keywords: product recalls,cross country,dynamic models
Accelerating investments and partnerships for EIC High Growth deep tech beneficiaries (EIC - ScalingUp)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Germany,Belgium,Bulgaria,France,France
Call: EIC Scalator Pilot (H2020-EIC-EICXXXPilot, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 7
Project status: SIGNED

Only 5% of European start-ups scale-up and pursue the position of world tech leaders. The growth barriers are high for truly high-risk deep-tech innovators, the main target of EIC instruments. Deep-tech innovators struggle to get required capital at the different stages of their lifecycle. The EIC-ScalingUP is set to create a blueprint for the EIC deep-tech growth companies to successfully scale and accelerate their investments and partnerships. It will identify, engage, select and feature 50 EIC companies with ability to become world-scale companies, select up to 30 and guide their growth plan and ambitions and create the blueprint of the tailored ScalingUP services. The execution of the defined blueprint will support the growth and funding of the 30 companies and foster exposure and connections with target stakeholders and networks with the aim to impact the key growth fundamentals and to lead to a successful Series B/C round or acquisition value, thus validating the EIC-ScalingUP blueprint. It is expected that 500+ Euro Million will be raised by the supported companies and inspirational success stories of EIC deep-tech companies will be broadly promoted to establish the EIC-ScalingUP as a credential of honour among Investment & Innovation communities. All activities in the EIC-ScalingUP are carried out by a consortium of 4 partners with complementary expertise: Coordinator Tech Tour (Networking & matchmaking between innovative SMEs; investors, corporates and advisors), Bpifrance (the French public investment bank assists businesses across stages and sectors and finances them from the seed phase to transfer to stocks exchange listing through loans, guarantees and equity), Boston Consulting Group (a global management consulting company with a deep understanding of the Deep Tech ecosystem) and Deepwave Ventures.

Keywords: growth,acceleration,investment,partnership
AppHub, the European Open Source Marketplace (AppHub)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Germany,France,France
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 849260.0
EU funding (EUR): 849260.0
Participants: 3
Project status: CLOSED

Many software engineering and cloud computing are developed in open source in order to implicitly avoid the curse of the European science paradox -- we are good at science but poor at exploitation – but fail because they lack adequate support and strategy. Open source provides an efficient framework for cooperation and IP management and that makes it indeed a powerful enabler for collaborative innovation. It is wrong however to assume that making the source available automatically attracts contributors and grants immediate market access. Open source as a convenient process is not the same as open source as a business strategy. The aim of this project is to support the market outreach strategies of EU-supported open source by launching AppHub, the European open source market place. AppHub is a service platform that will help the market to seamlessly identify, position and implement the software outcomes of these projects. The partners that will develop, run and promote AppHub over this two-year project and beyond combine unparalleled expertise in open source community management, EU research projects and a breakthrough technology in software asset management.

Keywords: apphub,open source,cloud services,quality management,community development
Development of a new highly efficient and fuel flexible CHP technology based on fixed-bed updraft biomass gasification and a SOFC (HiEff-BioPower)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Austria,Germany,Germany,Germany,Belgium,Netherlands
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 4997371.25
EU funding (EUR): 4997371.25
Participants: 9
Project status: CLOSED

Within the project a new highly efficient biomass CHP technology consisting of a fuel-flexible fixed-bed updraft gasifier, a novel compact gas cleaning system and a solid oxide fuel cell (SOFC) shall be developed for a capacity range of 1to 10 MW (total energy output). The technology shall distinguish itself by a wide fuel spectrum applicable (wood pellets, wood chips, SRC, selected agricultural fuels like agro-pellets, fruit stones/shells), high gross electric (40%) and overall (90%) efficiencies as well as equal-zero gaseous and PM emissions. The system shall consist of a fuel-flexible updraft gasification technology with ultra-low particulate matter and alkali metal concentrations in the product gas (which reduces the efforts for gas cleaning), an integrated high temperature gas cleaning approach for dust, HCl and S removal and tar cracking within one process step as well as a SOFC system which tolerates certain amounts of tars as fuel. It is expected to achieve at the end of the project a TRL of 5 and a MRL of at least 5. To fulfill these goals a methodology shall be applied which is divided into a technology development part (process simulations, computer aided design of the single units and the overall system, test plant construction, performance and evaluation of test runs, risk and safety analysis) as well as a technology assessment part covering techno-economic, environmental and overall impact assessments and market studies regarding the potentials for application. Moreover, a clear dissemination, exploitation and communication plan is available. The novel technology shall define a new milestone in terms of CHP efficiency and equal-zero emission technology in the medium-scale capacity range and shall contribute to a stronger and future-oriented EU energy supply based on renewables. Its fuel flexibility shall ensure high attractiveness and market application potential and thus strengthen the industrial base in the EU as well as the technological leadership.

Keywords: updraft gasifier,sofc,biomass,fuel flexibility,high temperature gas cleaning,zero emission
Connectivity Correlate of Molecular Pathology in Neurodegeneration (ConCorND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Neurodegenerative diseases (NDs) are incurable, debilitating conditions, arise mid-late in life, represent an enormous health and socioeconomic burden and no therapies exist. An enigmatic finding in NDs is the early and selective alteration in intrinsic excitability of vulnerable neurons paralleling changes in its circuitry. However, a gap in understanding exists in ND field about the cause of these alterations and whether these modifications regulate degenerative pathomechanisms. Our recent study, examining mechanisms of Purkinje cell (PC) degeneration in Spinocerebellar ataxia type 1 (SCA1) revealed that the earliest cerebellar alterations occur in the major excitatory inputs onto PCs, the climbing fibers (CFs). Based on this, we propose a novel three-step model of neurodegeneration: First, suboptimal functioning of the presynaptic inputs initiates signaling deficits in target PCs. Second, those alterations trigger maladaptive responses such as altered intrinsic PC excitability, thus amplifying pathogenic cascades. Third, at network level progressive dysfunction triggers compensatory synaptic modifications within the cerebellar circuitry. In this proposal, we will test our new hypothesis for NDs on SCA1 and this will be the first study to test circuit-dependency in NDs by selectively silencing presynaptic inputs and examining molecular responses in the postsynaptic neuron. Specifically, we will 1) Identify the dysfunctional CF associated molecular signature in PCs. 2) Elucidate mechanisms involved in altering intrinsic PC excitability. 3) Map the connectome for a structural correlate of the pathology. Using conditional mouse models, pharmacogenetics, transcriptomics, proteomics and connectomics, we will delineate molecular alterations that govern disease from compensatory alterations. Our systematic approach will not only impact SCA related therapies but the entire spectrum of NDs and has the potential to change the conceptual approach of future studies on NDs.

Keywords: neurodegeneration,spinocerebellar ataxia type 1,cerebellum,purkinje cells,circuits,mouse models,pharmacogenetics,rna sequencing,mass spectrometry,adeno associated viruses,behavior
Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Germany,Spain,Norway,Belgium,Finland,Sweden,Switzerland,France,United States,United Kingdom,United Kingdom,Denmark
Call: Multi omics for personalised therapies addressing diseases of the immune system (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2023-06-30
Duration (months): 78.0
Total project cost (EUR): 15041259.25
EU funding (EUR): 14721453.0
Participants: 25
Project status: SIGNED

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations. MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of €37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions. To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response. MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.

Keywords: multiple sclerosis,biomarkers,genetics,epigenetics,lifestyle exposures,immunophenotypes,multiomics,immune disorders
Hyperspectral Lightweight Imagers for micro-PlatformS (HyLIPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The HyLIPS project aims at the commercialization of two ultra-light hyperspectral imagers, one specifically designed to be hosted by microsatellites and devoted to the space market, and the other designed to be hosted by drones and unmanned aircrafts and aimed at a broader market. With the HyLIPS project, Sofasi aims at two key strategic objectives: - innovate the offer to its regular clients related to the space market (space agencies, public institutions, universities). To date Sofasi srl is committed to the testing of instruments for remote sensing, laboratory and in-field measurement. The new sensor will face another need of this type of clients, increasing enormously Sofasi’s business opportunities. - radically change its positioning in the business, from its previous state of consultancy firm, to a high-tech small producer. The idea behind the project is that in a medium term horizon, Sofasi srl will reach a new and wide market share (unmanned aircrafts market) thanks to the imager designed to be hosted by drones. The sensors can be partially scaled in order to be hosted by various types of platforms optimizing payload performance and budget requirements. The expected sensor mass is comprised between 0.1-0.2 kg, with a power absorption lower than 1 W and a linear size not exceeding 0.2 m. Such sensors could be hosted by several micro-platforms whose utilization is growing fast. The market shows an increasing offer of drones and microsatellites and is characterized by a substantial inadequacy of miniaturized payloads. The lack of reliable payloads with small mass and power absorption is the main obstacle to the diffusion and utilization of the micro-platforms. Today, miniaturized RGB cameras represent the most common sensor available for drones, while the offer of payloads for microsatellites is almost vanishing. The development of new payloads with improved discrimination ability would boost the market of platforms, payloads and their practical applications.

Keywords: hyperspectral remote sensing,cubesat,drones,ultra lightweight sensors,earth observation,planetary exploration,hardware scalability,programmable sampling,image processing