Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MSCA-GLOPOL: MSCA Global Cooperation: Policy Enhancement and Strategic Promotion (MSCA-GLOPOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Belgium
Call: MSCA International Cooperation 2024 (HORIZON-MSCA-2024-INCO-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 1989595.0
EU funding (EUR): 1989595.0
Participants: 2
Project status: SIGNED

The project aims to foster international collaboration in MSCA with the 26 targeted geographies (TG26) by ensuring alignment with formal R&I policy dialogues at both bilateral/regional levels as well as complementing/coordinating existing local promotion channels. MSCA-GLOPOL will comprehensively assess existing cooperation policies, monitoring participation in MSCA calls, and develop synergies with other EU R&I initiatives. It introduces a novel methodology that relies on 11 action-oriented approaches (Desk Research, Stakeholder Mapping, Survey, Focus Group, Qualitative Monitoring, Quantitative Monitoring, Policy Briefs, Promotional Events, Coordinated Promotion Plans, Training & Best Practice Forum, Synergies) which responds to sources-processes-results continuum. Strategically, the project will mobilise 13 Regional Liaison Officers (RLOs) in TG26. The RLOs are local experts with excellent national/regional knowledge and together with MCAA chapter representatives are in an unparalleled position to access the target groups. Critical expected outcomes include a broader global reach and deeper engagement in MSCA opportunities, more informed and adaptive bilateral and bi-regional cooperation strategies, and stronger alignment between MSCA activities and other EU initiatives. These impacts will directly benefit stakeholders such as EU and national policymakers, research institutions, researchers, and promotional actors who are essential to the success of MSCA and face challenges related to low awareness, uneven participation, and fragmented cooperation efforts. The consortium brings together a diverse but complimentary set of expertise. PRACSIS’s competence in providing policy insights, communication and dissemination ensures that the project’s outcomes have maximum impact and visibility while the MCAA’s experience in providing policy insights coupled with its global community of MSCA alumni provides invaluable understanding of local and European policy framework.

Keywords: marie sklodowska curie actions,international collaboration,policy dialogue,bi regional randi cooperation,bi lateral randi cooperation,strategic promotion,synergies
Advanced Single-Photon Sources Based on On-Chip Hybrid Plasmon-Emitter Coupled Metasurfaces (PhotonMeta)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 229982.4
EU funding (EUR): 229982.4
Participants: 1
Project status: CLOSED

Single-photon sources are crucial for many quantum information technologies, including quantum communications, computation, sensing and metrology. Typical stand-alone quantum emitters (QEs), such as quantum dots and defects in diamonds, feature low emission rates, nondirectional emissions, and poorly defined polarization properties, which prevents QEs from being directly used as single-photon sources in practical applications. Various micro/nano structures have been developed in recent years to enhance QE emission rates by making use of the Purcell effect via engineering their immediate dielectric environment, but the control of polarization, direction, and wavefront of the emitted photons has still been rarely addressed. The main objective of the project is to develop a general design approach for high-performance single-photon sources and demonstrate its use by designing and fabricating a series of advanced single-photon nanodevices with different functionalities. First, the underlying physics of QE coupling to surface nanostructures will be thoroughly investigated. We will then develop a novel holography implementation, vectorial scattering (computer-generated) holography, generating directly profiles of hybrid plasmon-QE coupled metasurfaces. Finally, based on the developed design approach, a series of nanodevices will be demonstrated, on-chip realizing photon emission with desirable polarization and phase profiles, including those of vector vortex beams. This project will enable the realization of single-photon sources with radiation channels that have distinct directional and polarization characteristics, extending thereby possibilities for designing complex photonic systems for quantum information processing. Furthermore, this project will facilitate knowledge exchange via dissemination activities along with researcher training in transferable skills, being fully committed to open science principles and chronicling the whole project in an open online logbook.

Keywords: metasurfaces,single photon sources,quantum emitters,plasmonics
Design of novel post-harvest technologies with low carbon footprint based on the discovery of active biomolecules (FRUITPRINT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Belgium,Germany,Türkiye,Spain,Italy,Greece
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1425342.86
EU funding (EUR): 1393800.0
Participants: 12
Project status: SIGNED

A main challenge for human societies is to feed the ever-increasing world population while limiting the carbon footprint inherent in food production activities. These seemingly opposing challenges must be reconciled. Securing sufficient amount of food requires to master the post-harvest storage of fruit and vegetables, the main source of nutrient for human, especially if we aim to reduce meet consumption due to its high carbon footprint. Controlled atmosphere is the main technology used to extend shelf-life of fresh products. It is mainly based on low temperature and low oxygen that reduce metabolic activity of fruit and vegetables, but it is energy consuming with high carbon footprint impact. On the other hand, 1-MCP, a chemical that prevents plants from sensing the plant hormone Ethylene, is also widely used in post-harvest storage to block ripening and senescence. It has a non-discriminating effects on different ripening processes leading to some alteration of organoleptic traits. FRUITPRINT project aims to identify novel bioactive molecules to improve storage and limit post-harvest losses while reducing energy consumption. The project consists of 3 main steps: (1) identification of novel bioactive molecules inhibiting ripening and senescence by in silico and in vitro screens of large libraries of chemical compounds, (2) evaluation of the effectiveness of the selected bioactive molecules in post-harvest storage, and (3) uncovering the molecular underpinnings of their beneficial effects on fruit and vegetables physiology. FRUITPRINT project rely on multidisciplinary approaches and complementary expertise from partners on virtual screening, oxygen sensing, fruit physiology and post-harvest storage. It will build on original and innovative material such as high-throughput screening platform, Bioluminescent plants and protein biosensors allowing in vivo screening, and facilities for post-harvest storage.

Keywords: fruit development,fruit ripening,post harvest,plant hormone,bioactive molecule
Graphene-based flexible perovskite solar cells for space applications (GPSpace)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: TERMINATED

The GPSpace project will address the use of graphene-based materials in solar cells for space applications, aiming to improve the stability of device architectures against the harsh environment in space. This research will evaluate the performance of graphene nanomaterials as electrodes and as interfacial layers regarding ultraviolet (UV) stability of metal halide perovskite solar cells under high vacuum. Additionally, this approach will contribute to the development of lightweight solar cells architectures with high specific power (EPw).

Keywords: perovskite solar cells,graphene,interface engineering,inorganic and organic chemistry,space based solar power
Rewiring transcriptional regulation by the PRC2 complex using proximity inducing pharmacology (Rewiring PRC2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 284915.66
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

Polycomb repressive complex 2 (PRC2), which incorporates repressive methyl-lysine marks on histone H3 to facilitate global transcriptional repression, is an integral epigenetic modifier in normal development. Components of this complex, especially EZH2, are hyperactive or overexpressed in a broad range of cancers, resulting in excessive silencing of tumor suppressor genes (TSGs). Moreover, cancers with defects in the SWI/SNF complex, the most frequently mutated chromatin regulatory complex in cancer, are dependent on PRC2 function for survival. While inhibition or degradation of PRC2 components have become extremely attractive approaches to cancer therapy, they still suffer from suboptimal kinetics and perturbation because they must rely on opposing epigenetic modifiers and transcriptional regulators to derepress expression of silenced TSGs. Thus, I aim to overcome this issue by leveraging the cancer driver itself to derepress silenced TSGs. In this regard, I will utilize a high-throughput protein recruitment screen, coupled to next-generation sequencing, to identify proteins (effectors) that, when recruited to PRC2, can rewire its function to directly derepress a PRC2-silenced locus. This screen will be used a base to develop novel proximity inducing compounds, which can rewire the function of PRC2. The compound that produces the strongest transcriptional derepression and anti-proliferative effects in cancer cells will then be characterized via transcriptomics, and chromatin profiling to determine its effects on endogenous gene expression. Ultimately, this study will establish a new class of PRC2 targeting compounds that will pave the way for improved cancer therapies, which both inhibit PRC2 methyltransferase activity and directly derepress PRC2-silenced TSGs.

Keywords: polycomb repressive complex,proximity inducing pharmacology,transcriptional regulation,chemical biology
Scalable Graph Algorithms for Bioinformatics using Structure, Parameterization and Dynamic Updates (SCALEBIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1999868.0
EU funding (EUR): 1999868.0
Participants: 1
Project status: SIGNED

Sequencing technologies have developed to be cheap and accurate, leading to major breakthroughs, such as the complete sequence of a human genome, the creation of nationwide population gene banks, or the discovery of novel viruses. As the amount of data produced grows exponentially and their applications become more broad and complex, the community needs accurate computational methods that scale. At the core of many algorithmic methods for processing sequencing data is the basic primitive of finding a set of paths or walks in graphs of various nature. Under different formulations and objective functions, the resulting problems can be NP-hard (e.g. flow decompositions) or polynomial-time (e.g. path covers), which are impractical on large graphs. Thus, many practical tools prefer fast heuristics to exact algorithms. While these may be optimized for specific inputs, they may not be reliable or accurate in general, which is a highly relevant issue in e.g. medical and life-science research. This project will develop general methods to massively scale such exact graph algorithms. First, via novel graph structures usable in a preprocessing step: safety structures, e.g. sets of paths that can be quickly found to appear in all optimal solutions and thus simplify the problem; variation structures that limit the hardness of a problem only to graph areas rich in genetic variation. Second, via modern algorithmic techniques: parameterizing polynomial algorithms to run in time linear in the graph size and superlinear only in a small parameter; dynamic algorithms that, as the input grows, update solutions based only on the new data. We will apply these methods in two high-impact applications: long-read RNA transcript discovery, and indexing massive and rapidly growing genomic databases. This project paves the way for exact graph algorithms usable independently of the problem complexity or of the input size, applicable to real-world problems.
Nanoscale Isotropic 3D Resolution using Omni-view Structured Light Sheet Microscopy (Nanocubic)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2293558.0
EU funding (EUR): 2293558.0
Participants: 1
Project status: SIGNED

After spectacular advances in microscopy, a next leap is needed to enable biological studies at the deep sub-cellular scale of cells in their native multi-cellular tissue environment. Currently, it is impossible to image in 3D with isotropic resolutions below 100 nm over volumes larger than (100 micron)^3. I want to disprove the paradigm that there should always be a trade-off between resolution, imaging volume and sample longevity. Building on my track record in super-resolution microscopy, I propose a revolutionary optical architecture where the volume is illuminated and scanned sequentially using three tilted 2D light sheets that form three mutually orthogonal planes. These light sheets are created by illumination from both sides of the sample to form interference-based light patterns with fine 200 nm scale pitch. Together with new structured illumination image reconstructions this enables a 3D fully isotropic resolution twice as good as conventional light sheet microscopy. In a second conceptual advance, the patterned light sheets are applied in single-molecule imaging to achieve 3D isotropic enhanced localization precision at the 1 nm level, an order of magnitude better than current methods. The omni-directional illumination and imaging also enables refractive index tomography, leading to time and space-variant point spread functions. These are used in-silico in first-ever super-resolution image reconstructions that are fully adapted to volumetric sample heterogeneity. In a final step, the tomographic refractive index data is projected to spatio-temporal aberration maps that are fed into adaptive optics for dynamic correction of sample-induced aberrations to boost super-resolution imaging of live cells over extended times. The envisioned suite of information-optimal computational microscopy modalities, rooted in fundamental physics, not only overcomes imaging barriers but also paves the way to break open black box approaches in image reconstruction.

Keywords: microscopy,super resolution,light sheet,adaptive optics
A Sea of Opinions: British Advises on the Philippines’ US Government in Asian Transcolonial Public Spheres, 1898-1916 (SoOP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Philippines,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 189258.6
EU funding (EUR): 189258.6
Participants: 3
Project status: SIGNED

This project delves into the British influence on the US colonial rule in the Philippines (1898-1916). It studies how Britons in the archipelago and nearby Asian colonial posts swayed the local US rule to protect their interests in the islands. The project hypothesizes they shared advice on the best forms to govern the Philippines through diplomatic and commercial lobbying and the Anglophone press published in ports like Hong Kong, Rangoon, or Penang—which, as recent historiography has demonstrated, constantly flowed around Asian ports. All this information defended the establishment of a protectorate that granted Filipinos some degree of selfgovernment and the preservation of Philippine markets open for commerce. Through an analysis of the Anglophone Asian media, the archives of the people whose interests they represented, and the archives of the American colonial elites that received them, this project will elucidate how these powerful British communities in Asia conditioned another empire’s colonial rule, building upon recent developments in transimperial history. Also, this research explores the influence Britons exercised over Filipino elites. It inquires whether influential Filipino political leaders—some of whom had been exiled to British ports like Hong Kong—also considered British opinions when strategizing the best way to face the US presence in the archipelago. Moreover, it will explore how they used these nearby British media, uncensored by the US authorities, to attack the US administration in the islands, knowing that its content could arrive there. More broadly, this project proposes to understand the Southeast Asian Public spheres, like that of the Philippines and nearby ports, as connected spaces of debate, where citizens of alien nations and colonized subjects without political power could express their points of view and influence those who did have authority.

Keywords: united states empire philippines british empire in asia colonial public spheres
Multi-messenger soft-field spectroscopy of molecular electronics at interfaces (SoftMeter)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

The real-time interrogation of molecular electronics at the interface between different media is key to understanding the fundamental mechanisms at the basis of processes such as catalysis, solar energy harvesting, and charge transport in optoelectronic devices. Such an investigation ultimately requires attosecond temporal resolution and picometer spatial accuracy, to capture in real-time the energy exchanges mediated by the electron wave function and the competing structural changes of the target. Experimental strong-field-laser physics has been demonstrated to provide outstanding spectroscopical methods for this purpose, such as high-harmonic generation spectroscopy, attosecond science, and laser-induced electron diffraction. However, it also presents intrinsic limitations such as high peak intensities, low efficiency, and poor tunability. These obstacles have so far hindered its application to the study of high-complexity systems, for example complex interfaces. SoftMeter aims at filling this gap. We are proposing a novel multi-messenger two-color spectroscopy, namely soft-field spectroscopy, that converts the concepts of strong-field physics into the moderate or weak field regime and overcomes its limitations, while still providing an unprecedented spatiotemporal resolution. The new protocol will be developed in the first phase of the project: It is based on an interferometric setup combining few-fs ultraviolet pulses with few-cycle IR pulses, and on the multi-messenger measurement of the laser-induced electron diffraction and the high-harmonic radiation of the target. In the second phase of the project, the novel soft-field scheme will be employed for the real-time interrogation of electronics at molecular interfaces. SoftMeter will pave the way for a new class of ultrafast laser spectroscopy experiments, with a large impact on several disciplines, ranging from photo-chemistry to biology, as well as from energetics to environmental science.

Keywords: molecular electronics photo induced dynamics at interfaces