Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Diversification through Rotation, Intercropping, Multiple cropping, Promoted with Actors and value-Chains Towards Sustainability (DiverIMPACTS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Bio-based Industries Joint Technology Initiative (BBI-JTI)
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Italy,Belgium,Belgium,Romania,Sweden,Belgium,Sweden,Switzerland,Switzerland,Poland,Poland,Switzerland,Belgium,Poland,Hungary,Latvia,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Crop diversification systems for the delivery of food, feed, industrial products and ecosystems services - from farm benefits to value-chain organisation (H2020-RUR-2016-2, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 11192323.5
EU funding (EUR): 9999985.0
Participants: 46
Project status: CLOSED

The overall goal of DiverIMPACTS is to achieve the full potential of diversification of cropping systems for improved productivity, delivery of ecosystem services and resource-efficient and sustainable value chains by (i) assessing performances of crop diversification through rotation, intercropping and multiple cropping, (ii) providing rural areas actors with those key enablers and innovations that would remove existing barriers and ensure actual uptake of benefits of crop diversification at farm, value chain and territory levels and (iii) make recommendations to policy-makers to facilitate the coordination of all relevant actors within the value chain. DiverIMPACTS will build on existing experiences of crop diversification by networking and expanding 10 existing field experiments to quantify impacts of crop diversification and by accompanying 25 multi-actor case studies in their dynamic transition. DiverIMPACTS will propose a range of technical and organisational innovations to remove lock-ins from farmers to consumers as well as strategies and recommendations to sustain crop diversification. The consortium gathers a wide range of actors (farmers and farmer organisations, advisory services, cooperatives, logistic providers, scientists, industry, representatives of civil society and of rural areas). Through a multi-actor approach, DiverIMPACTS will accompany and support innovation groups in their dynamic process to develop sustainable value chain systems characterised by a high level of crop diversification and new market products. The consortium involves pioneer actors of crop diversification and has strong experience in both the design and multi-criteria assessment of innovative systems and the analysis of barriers that impede the transition towards sustainable diversified systems that contribute to the Rural Renaissance objectives.

Keywords: crop diversification,ecological intensification,resources efficiency,rural innovation,systems approach
Energy Social sciences & Humanities Innovation Forum Targeting the SET-Plan (Energy-SHIFTS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Spain,Spain,Belgium,Norway,Poland,Finland,Netherlands,United Kingdom
Call: Support to sectorial fora (H2020-LC-SC3-2018-Joint-Actions-3, 2018)
Start date: 2019-04-01
End date: 2021-07-31
Duration (months): 28.0
Total project cost (EUR): 1014560.0
EU funding (EUR): 1014560.0
Participants: 9
Project status: CLOSED

Energy-SHIFTS “Energy Social sciences & Humanities Innovation Forum Targeting the SET-Plan” will contribute to a European Energy Union that places societal needs centrally, by further developing Europe’s leadership in using and applying energy-related Social Sciences and Humanities (energy-SSH). Our consortium brings together 4 leading interdisciplinary research institutes with 3 highly respected policy, industry and communications organisations from across the energy-SSH field, to create an innovative and inclusive Forum. Our partners have significant energy-SSH H2020 project experience, direct working links with the EU’s Strategic Energy Technology Plan (SET-Plan) communities, extensive networks in the energy domain, and represent excellent coverage across SSH disciplines and across Europe. These will enable us to maximise the impact of our Forum delivery within an intensive 2-year project. Energy-SHIFTS activities will target over 10,000 stakeholders and begin with scoping activities including: accessible guides to SSH in EU policy; workshops on SSH priority themes; online policyworker and researcher databases. We will build on this scoping work to implement: 4 Working Groups across SET-Plan themes; a Policy Fellowship scheme; an Early-Stage Researcher programme; masterclasses for policy, NGO, STEM, and media audiences; 4 online citizen debates; and a pan-European conference. Our consortium will bring their considerable expertise in research-policy dialogue to these activities. Our core activities will both provide immediate insights for the short-term directions of EU energy policy as well as foundations for longer-term mechanisms that will enable evidence-based energy-SSH insights to reach the ‘policy front line’. As a central body bringing SSH communities together, we will work to directly inform future FP9 and SET-Plan priorities. Energy-SHIFTS will significantly enhance the policy impact of energy-SSH, and accelerate shifts to low-carbon energy systems.

Keywords: social sciences and humanities,multi stakeholder,energy research,policy and innovation,innovative collaboration methods,forum
Modelling Trust-based Evolutionary Dynamics in Signed Social Networks (TEAMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Users’ experience with real-world social systems (e.g., Epinions and eBay) witnesses the importance of Signed Social Networks (SSNs) that have wide practical and valuable applications in social media such as opinion guidance, personalized recommendation, and topic identification. However, the diversity of massive social interactions complicates the trust and distrust relations among users in SSNs. In particular, the complexity of distrust relations leads to significant challenges in detecting the trusted communities and capturing their evolutionary patterns. This research aims to pioneer the innovative mechanisms for detecting the trusted communities and learning the evolutionary dynamics. To this end, we will explore the representation mechanism for SSNs by using the Formal Concept Analysis (FCA) and develop a FCA-based representation model. Next, the mechanisms and corresponding algorithms for detecting trusted communities and identifying their dynamic evolutions will be investigated. This research will provide both theoretical fundamentals and practical techniques for detection and dynamic evolution of trusted communities in SSNs. Moreover, this project can stimulate new research directions and the collaborative opportunities across multiple disciplines, such as social computing, soft computing and networking. To broaden the fellow’s knowledge horizon, a series of research, training, and knowledge transfer activities are planned. The new knowledge and skills imparted in these activities will further promote the applicant’s research portfolio and significantly enhance his career prosperity. The research will also lay a solid foundation for the long-term and wide-range collaborations between the fellow and the host university, and eventually lead to more extensive and higher impact of research results, from which both EU and China will benefit.

Keywords: social networks,social computing,trust,trusted communities
Sorting of Self (SOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1479781.0
EU funding (EUR): 1479781.0
Participants: 1
Project status: CLOSED

During inflammation and infection, we are simultaneously confronted with both self and non-self in form of dying cells and microbes, respectively. Mechanisms that facilitate the non-immunogenic clearance of self-antigens derived from apoptotic and necrotic cells and that, in parallel, allow the initiation of an immune response against invading pathogens are incompletely understood. Recent data from our laboratory show that the immune system actively sorts apoptotic cells (ACs) and bacteria into distinct subspecies of macrophages and dendritic cells thereby enabling a segregated processing of self and non-self as well as a differential immune response against these two entities. Incorrect sorting and aberrant uptake of AC-derived self-antigens by pro-inflammatory and antigen-presenting dendritic cells, however, results in the break of self-tolerance and autoimmunity. Due to technical limitations, the identification and fate-mapping of specific phagocyte subsets that mediate the simultaneous clearance of dying cells and pathogens in vivo has remained largely elusive. We thus plan to develop novel tools that are based on cutting-edge technologies to comprehensively elucidate the sorting of dying cells and pathogens under inflammatory conditions in vivo. We plan to generate TAT-Cre transgenic mice and bacteria that will be used in conjunction with R26-eYFP reporter animals to permanently track phagocytes after ingestion of endogenously accumulated dying cells and pathogens, respectively. These approaches will enable us to characterize the involved phagocytes, study molecular mechanisms underlying the differential processing of self and non-self and follow the phagocyte’s migratory behaviour and its subsequent differentiation. The obtained data will not only provide insights into the pathogenesis of autoimmune and infectious diseases, but will also foster the development of novel therapeutic strategies for the treatment of such disorders.

Keywords: autoimmunity,clearance of apoptotic cells
Matrix during cancer progression (MATRICAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1997500.0
EU funding (EUR): 1997500.0
Participants: 1
Project status: CLOSED

The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer patient deaths. In order to do this, my lab has developed a method to in situ decellularise organs leaving structurally intact ECM scaffolds for subsequent analysis or for repopulation to study cell-ECM interactions in situ. We have deployed our method to decellularise primary tumour and metastatic organs in mice bearing orthotopic breast cancer tumours for subsequent quantitative global mass spectrometry (MS) proteomics, spatio-structural mapping of ECM components in 3D, and live imaging of repopulated cells. We observed fundamental alterations in ECM composition and structure between normal and tumour, and primary and metastatic tissue. We have selected two ECM components specifically upregulated in metastatic organs for subsequent validation. We discovered a marked decrease in proteins associated with fibrillogenesis in metastatic organs and will investigate the impact of this on metastatic ECM stiffness. We will decellularise organs from transgenic mouse models of breast and pancreatic cancer, at specific stages during cancer progression to determine the evolution of global ECM composition and structure, and how this impacts on cell behaviour through functional perturbation. Finally, we shall validate relevance of findings to human disease through use of human cancer lines and analysis of human patient samples. The research proposed will provide ground-breaking insight into how the ECM regulates cellular behaviour during normal and pathological conditions, and will test new strategies to combat metastasis that could be translated into the clinic to benefit cancer patients.

Keywords: metastasis,extracellular matrix
How to break Mendel’s laws? The role of sexual conflict in the evolution of unusual transmission genetics (PGErepro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2025-06-30
Duration (months): 78.0
Total project cost (EUR): 1494055.0
EU funding (EUR): 1494055.0
Participants: 1
Project status: SIGNED

Under Mendelian inheritance, individuals receive one set of chromosomes from each of their parents, and transmit one set of these chromosomes at random to their offspring. Yet, in thousands of animals Mendel's laws are broken and the transmission of maternal and paternal alleles lose their symmetry. A large body of theory suggests that these asymmetries might arise because of maternal–paternal genetic conflict, but empirical tests are sorely needed to test whether the plausible is actual. This proposal aims to understand why, when and how the transmission of genes from one generation to the next deviates from Mendel’s laws. We ask how different types of sexual conflict -- both directly between parents (interlocus sexual conflict), indirectly between the parent’s genes within their offspring (intragenomic sexual conflict), and between genes expressed in males and females (intralocus sexual conflict) -- can affect the evolution of non-Mendelian reproduction. We focus on species with extreme reproductive asymmetry known as Paternal Genome Elimination (PGE). PGE males systematically transmit only those chromosomes that they inherited from their mother. This unusual reproductive strategy is thought to originate from a clash of interests between the sexes, where mothers have “won” by monopolizing the parentage of their sons. Although PGE is rarely studied, its repeated evolution and experimental tractability make it an ideal test case for understanding the role of sexual conflict in the evolution of genetic systems.

Keywords: sexual conflict,transmission genetics,sex determination,entomology,genomic imprinting,reproduction,meiotic drive
Renewable materials and healthy environments research and innovation centre of excellence (InnoRenew CoE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Slovenia,Slovenia,Slovenia
Call: Teaming Phase 2 (H2020-WIDESPREAD-01-2016-2017-TeamingPhase2, 2016)
Start date: 2017-04-01
End date: 2023-09-30
Duration (months): 78.0
Total project cost (EUR): 14996025.0
EU funding (EUR): 14996025.0
Participants: 10
Project status: SIGNED

Slovenia was identified as a region lagging in innovation within the Horizon2020 WIDESPREAD 2014-1: Teaming call for proposals, and this is is particularly noticeable in the country's forest-based value chain. However, the vital core of Slovenia’s renewable resource-based value chain has retained access to international markets and a significant production capacity in spite of an overall workforce reduction. Therefore this industry exhibits a strong potential for growth, which was identified in the Smart Specialization Strategy of Slovenia. The Smart Specialization Strategy of Slovenia calls for inter-sectoral networking and integration of the wood chain in the design of homes and working environments of the future. It promotes research and innovation deriving from traditional knowledge and skills related to wood and wood-compatible natural materials and seeks to increase added value and export of companies by 15% by 2023. In order to leverage this potential by facilitating collaborations between industry and academia in this sector, the Renewable materials and healthy environments research and innovation Centre of Excellence (InnoRenew CoE) was established. With support and guidance from the advanced partner, Fraunhofer WKI, scientific research and development activities will be transferred rapidly and effectively to the industry and through them to society in the form of innovative new products and processes.

Keywords: renewable resources,renewable materials,building materials,building systems,built,environment,human well being,innovation,living laboratory,ergonomic design
Low Temperature Plasma for Applications in Medicine (LTPAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.

Keywords: plasma chemistry,biomedical plasma,secondary chemistry in solutions,reactive species,radicals,experimental studies
Next GenerAtion MateriAls and Solid State DevicEs for Ultra High Temperature Energy Storage and Conversion (AMADEUS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Norway,Greece,Poland
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 3270496.25
EU funding (EUR): 3270496.25
Participants: 7
Project status: CLOSED

This project will investigate the next generation of materials and devices for latent heat thermal energy storage (LHTES) at ultra-high temperatures of up to 2000ºC, which are well beyond today's maximum operation temperatures of ~1000ºC. We will synthetize new phase change materials (PCMs) with latent heat in the range of 2-4 MJ/kg (an order of magnitude greater than that of typical salt-based PCMs); we will develop advance thermal insulation and PCM casing designs, along with novel solid-state heat to power conversion technologies able to operate at temperatures up to 2000ºC. Using these new materials and devices, we aim at realizing the proof of concept of a new kind of extremely compact LHTES device with unprecedented high energy density. The key enabling technologies are: novel PCMs based on the silicon-boron system with ultra-high melting temperature and latent heat, novel refractory lining composites based on carbides, nitrides and oxides for the PCM container walls, advanced thermally insulated PCM casing for ultra-high temperature operation, and novel solid-state heat-to-power converters based on photovoltaic and thermionic effects. In this regard, we will perform the proof of concept of a new kind of hybrid thermionic-photovoltaic converter (TIPV) that has been recently formulated theoretically. TIPV cells combine the ionic and photovoltaic phenomena to convert high temperature heat directly into electricity at very high power rates. The final goal of this project is to demonstrate the proof-of-concept of this idea and kick-starting an emerging research community around this new technological option.

Keywords: ultra high temperature,latent heat thermal energy storage,refractories,solid state heat to power conversion,phase change material,photovoltaics,thermionics