Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing a Child Cohort Research Strategy for Europe (CHICOS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Coordination and support actions
Countries involved: Denmark,Greece,Italy,Netherlands,Norway,United Kingdom,Denmark,Spain,Greece
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-01-01
End date: 2013-02-28
Duration (months): 38.0
Total project cost (EUR): 1668066.11
EU funding (EUR): 1490124.0
Participants: 9
Project status: CLOSED

Mother-child cohorts are currently collecting a wealth of information on childhood diseases and their determinants across Europe, but these data are often of fragmented nature and there is little coordination to structure and consolidate scattered research. Although cohort research carries large potential policy implications, messages are not always filtering through to policy at the national, let alone the European, level. CHICOS aims to improve child health across Europe by developing an integrated strategy for mother-child cohort research. This will be achieved through the coordination of the most important European cohorts. The project will 1) make an overview of all mother-child cohorts in Europe; 2) evaluate existing information on outcomes and determinants from these cohorts, evaluate links between cohorts and routine registers, identify gaps in knowledge, and develop recommendations for research action at European level for the next 15 years focusing on key areas of policy concern; 3) review the extent to which mother-child cohorts and registries have contributed to current European child health policies and make recommendations to improve the contribution of mother-child cohort research to policy at the European level; and 4) disseminate results of the project to stakeholders and evaluate new technologies for cohort research dissemination. CHICOS is structured along key child health outcome themes (perinatal outcomes, asthma, obesity, cognitive and behavioural development, injuries, infections, childhood cancer) and key determinant themes (social inequalities, nutrition and exercise, lifestyle exposures, environmental toxin exposures, genetic factors and biobanks, multiple risk factors) where European cohorts can and should work together towards a more solid evidence base, which can be used by policy makers. CHICOS will work closely with policy makers to ensure that guidelines across Europe in these areas are based on the best available evidence.

Keywords: child health,birth cohorts,mother-child cohorts,research priorities,social inequalities,policy impact
Community-embedded Reproductive health Care for Adolescents (CERCA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Belgium,Ecuador,Lithuania,Netherlands,Bolivia, Plurinational State of,Nicaragua
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 3644260.0
EU funding (EUR): 2893700.0
Participants: 7
Project status: CLOSED

Adolescents in Latin America are confronted with serious sexual and reproductive health problems. Besides the negative physical effects, poor sexual and reproductive health brings about social threats for adolescents. The CERCA project aims to contribute to the global knowledge about how health systems could be more responsive to the sexual and reproductive health needs of adolescents and by extension to the other health needs of their populations. In a first phase the determinants for sexual and reproductive health for adolescents will be analysed in research settings in three Latin American cities: Cochabamba in Bolivia, Cuenca in Ecuador, and Managua in Nicaragua. Subsequently a comprehensive strategy for community-embedded interventions will be developed that targets at improved access to adolescent-friendly reproductive health care in primary health services, a supporting and enabling environment and strengthened adolescent competence to make reproductive health choices. A strong emphasis will be put on the use of media (internet and text message on mobiles) to reach adolescents for empowering actions. The strategy will be implemented and tested on its impact and applicability. The analysis of the implementation processes and the evaluation results will help to develop a framework for community-embedded interventions that improve the responsiveness of health systems to health needs. Community-participatory action research will be the main methodology for the development of the intervention strategy and the framework. A randomised control and a quasi experimental study will be used for the impact evaluation. Policy makers will be continuously involved in the research project as a part of the project strategy to bridge the gap between health research and health policies.

Keywords: sexual and reproductive health adolescents internet action research latin america primary care community participation
New European WAtcher (NEWA)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Coordination and support actions
Countries involved: Italy,Italy,Spain,France,Spain,United Kingdom,France,United Kingdom
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-08-01
End date: 2012-03-31
Duration (months): 20.0
Total project cost (EUR): 765441.23
EU funding (EUR): 577884.03
Participants: 9
Project status: CLOSED

The NEWA project aims at addressing and fully characterizing limiting factors in EU which limit the access to required technology and capabilities, creating large dependence on critical technologies from outside Europe specifically in space techniques applications. This mainly originates from the large number of past and on-going efforts conducted in space-based and air-based surveillance systems design and development in the US. In particular NEWA will be focussed on Techniques and Technology development in the MTI framework. The idea for space-based MTI capabilities was envisaged several years ago, and experiments and pre-cursor programs were implemented in the US since 90ies. However, achievements and findings are not generally public due to dual-use of such components (Defence and Security), which poses restrictions on their export. NEWA Action is intended to perform a thorough Technology Assessment and identify ad hoc Roadmaps for EU Research & Development in the field of space-based Reconnaissance & Surveillance (R&S), which allow reducing the mentioned dependence from non EU capabilities and technologies. The NEWA results will offer a way to European policy makers and main stakeholders (industrial players and institutions) for efficiently directing common efforts towards a shared objective: the establishment of next-generation space-based R&S capabilities in support of the European Security and Defence Policy.

Keywords: reconissance,surveillance,security,roadmap
Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative (IDEA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Switzerland,Netherlands,United Kingdom,United Kingdom,Germany,Kenya,United Kingdom,France,Italy,Nigeria,Tanzania, United Republic of,Netherlands,Germany,Gabon,Germany,United States
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-03-01
End date: 2015-08-31
Duration (months): 66.0
Total project cost (EUR): 13728795.68
EU funding (EUR): 10300000.0
Participants: 23
Project status: CLOSED

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.

Keywords: worms,co-infection,hiv,malaria
Cancer Genomics of the Kidney (CAGEKID)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,France,Czechia,Germany,Sweden,United Kingdom,Latvia,Sweden,Russian Federation,Canada
Call:  (FP7-HEALTH-2009-two-stage, 2009)
Start date: 2010-03-01
End date: 2014-08-31
Duration (months): 54.0
Total project cost (EUR): 13747768.05
EU funding (EUR): 10500000.0
Participants: 15
Project status: CLOSED

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to this effort through application of state-of-the-art approaches to the genomics of the most common form of renal cell cancer (RCC). RCC is of particular importance within Europe where the highest global incidence rates are observed. Disease incidence has increased over the last two decades, and it is now the 8th most common cancer in the EU. CAGEKID brings clinical and epidemiological resources that are unique worldwide together with the necessary genetics and genomics expertise required for this effort. In the first phase of the study, we will provide a full genomic characterisation of 100 matched pairs of DNA extracted from the tumour and constitutional samples. DNA will be completely sequenced, and the data brought together with those from whole genome transcript and methylation analyses. Follow-up studies of potential targets will be made in further samples. The results acquired will be relied to targeted protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and storage of biological samples. CAGEKID will provide the first systematic analysis of this tumour site providing new insights into disease aetiology with application for diagnosis and treatment. It addresses a major need to identify new biological markers for renal cell cancer, one of very few tumour types for which there are currently no biological markers in routine clinical use. Renal cancer is not yet supported by any of the members of the ICGC.

Keywords: cancer,genomics,kidney,renal cell cancer,sequencing,icgc
An Integrated Tool-Kit for the Clinical Evaluation of Microbial Detection and Antibiotic Susceptibility Point-of-Care Testing Technologies (TEMPOTEST-QC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Italy,France,Belgium,Netherlands,United Kingdom
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-02-01
End date: 2013-05-31
Duration (months): 40.0
Total project cost (EUR): 4111659.8
EU funding (EUR): 3064462.0
Participants: 6
Project status: CLOSED

The TEMPOtest project proposal addresses the need to “design integrated tools for closing the gap between microbiological point-of-care technologies and actual clinical need”, by designing, developing and implementing a microbiological point-of-care “tool-kit” comprising i) a survey providing information on Europe-wide demand for point-of-care microbiological tests, ii) an archive of freely available quality control/quality assurance microbiological test samples for rapid evaluation of point-of-care microbiological tests, iii) a freely available Comparison Tool comprising specimen archive/software tool to rapidly determine sensitivity, susceptibility, reproducibility and time to diagnosis for new microbiological point-of-care technologies compared to current routine clinical microbiological protocols, iv) the optimization and development of electronic nose and antimicrobial resistance gene microarrays as future technologies for microbiological point-of-care testing and v) the development of supporting database and internet facilities.

Keywords: tool-kit,point-of-care,microbial detection,antimicrobial resistance,evaluation
Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity (NIMBL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,Italy,United Kingdom,Netherlands,Spain,United States
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-06-01
End date: 2013-11-30
Duration (months): 42.0
Total project cost (EUR): 6978247.06
EU funding (EUR): 5396993.0
Participants: 9
Project status: CLOSED

Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL conditions are rare, but under diagnosed. No effective treatments or cures exist at present. To enable optimum patient care in Europe and worldwide, a better understanding of the natural course of these disorders and their underlying pathological basis is essential. In the NIMBL project, European and U.S. clinical and basic scientists at the forefront of NIMBL-related research have united to develop a translational approach to these problems. A registry of patients will reveal the natural history of the NIMBL diseases, and the efficacy of current treatments. Investigation of patients together with the use of existing and novel cellular and animal models will precisely define their pathogenesis and identify potential drug targets. These same platforms will then be used to test existing and new drug treatments, thus providing unique opportunities to European companies. The NIMBL project will build on very recent discoveries of the cell-intrinsic initiation of autoimmunity that we have described, and which have major implications for our understanding of the discrimination of self from non-self. This new biological paradigm involves cytosolic sensors that detect accumulated, endogenous nucleic acids, and induce the body to mount an immune response against its own cells. Thus, the investigation of NIMBL diseases will not only improve the health and well-being of NIMBL patients and their families, it will also lead to better treatments of much more common autoimmune disorders including lupus.

Keywords: rare disease neurological natural history pathogenesis therapy
Accelerating the transition to a toxicity pathway-based paradigm for chemical safety assessment through internationally coordinated research and technology development (AXLR8)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Coordination and support actions
Countries involved: Germany,Belgium,United Kingdom
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-01-01
End date: 2013-10-31
Duration (months): 46.0
Total project cost (EUR): 612800.0
EU funding (EUR): 555223.0
Participants: 3
Project status: CLOSED

Conventional approaches to toxicity testing and risk assessment are often decades old, costly and low-throughput, and of dubious relevance to humans. These factors have prompted leading scientific bodies to call for a transition to a 21st century paradigm, including a move away from apical outcomes at high doses in whole animals, and toward a mechanistic understanding of the source-to-outcome continuum between xenobiotic exposure and adverse health effects. Such a shift will require a robust understanding of the cellular response/toxicity pathways which that can lead to adverse effects when perturbed; appropriate in vitro systems to study chemical interactions at key targets along a pathway; and computational systems biology models to describe the “circuitry” underlying each pathway as a basis for creating biologically realistic dose-response models. The AXLR8 project aims to support the transition to a toxicity pathway-based paradigm for quantitative risk assessment, and to this end will: 1) Organise a series of scientific workshops and expert meetings to map and catalogue research progress, gaps and needs in the above areas. 2) Provide a range of tools and opportunities for enhanced interdisciplinary and international communication, coordination and collaboration in order to maximise the impact of available resources. 3) Work to streamline regulatory acceptance procedures to provide for the expeditious uptake of validated 3Rs methods, including a smooth transition to 21st century systems as they become available. 4) Produce an authoritative report on the state of the science, including a practical roadmap detailing priority research and funding targets, in order to ensure a prominent role for European science in this rapidly developing global research area.

Keywords: bioinformatics,computational systems biology,high throughput,in vitro,toxicity pathways,risk assessment
Mechanisms of microRNA biogenesis and turnover (MIRTURN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Switzerland
Call:  (ERC-2009-StG, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 1782200.0
EU funding (EUR): 1782200.0
Participants: 2
Project status: CLOSED

MicroRNAs (miRNAs) are a novel class of genes, accounting for &gt;1% of genes in a typical animal genome. They constitute an important layer of gene regulation that affects diverse processes such as cell differentiation, apoptosis, and metabolism. Despite such critical roles, deciphering the mechanism of action of miRNAs has been difficult, leading to multiple, partially contradictory, models of miRNA activity. Moreover, adding an additional layer of complexity, it is now emerging that miRNA activity is regulated by various mechanisms that we are only beginning to identify. Our objective is to understand how miRNAs are regulated under physiological conditions, in the roundworm Caenorhabditis elegans. We will focus on pathways of miRNA turnover, an issue of fundamental importance that has received little attention because miRNAs are widely held to be highly stable molecules. However, miRNA over-accumulation causes aberrant development and disease, prompting us to test rigorously whether degradation can antagonize miRNA activity and either identify the machinery involved, or confirm the dominance of other regulatory modalities, whose components we will identify. C. elegans is the organism in which miRNAs and many components of the miRNA machinery were discovered. However, previous studies emphasized genetics and cell biology approaches, limiting the degree of mechanistic insight that could be obtained. In addition to exploiting the traditional strengths of C. elegans, we will therefore develop and apply biochemical and genomic techniques to obtain a comprehensive understanding of miRNA regulation, enabling us to demonstrate both molecular mechanisms and physiological relevance. Given the importance of miRNAs in development and disease, identifying the regulators of these tiny gene regulators will be both of scientific interest and biomedical relevance.

Keywords: posttranscriptional gene regulation,noncoding rna,in vivo
Children of Prisoners, Interventions & Mitigations to Strengthen Mental Health (COPING)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,Germany,Romania,Sweden,Switzerland,France,Sweden,Germany
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 3738820.12
EU funding (EUR): 2682813.4
Participants: 10
Project status: CLOSED

COPING presents a child-centred research strategy covering four European countries, the UK, Germany, Romania and Sweden, which will identify the characteristics of children with imprisoned parents, their resilience, and their vulnerability to mental health problems. This group of children are exposed to triple jeopardy through break-up of the family, financial hardship, and extremes of stigma and secrecy, leading to adverse social and educational repercussions. None of the four countries so far recognises the extreme disadvantage experienced by these young people. Support available, for example, in accessing prisons and participating in prison visits is extremely variable and mainly provided through non-governmental organisations. Support for imprisoned parents, whose moral authority is diminished through their incarceration, is equally inconsistent. The COPING research strategy places the clearest emphasis on knowledge obtained directly from children and young people. The project will commission surveys of 200 children in each country aged 11-16 with an imprisoned parent, using the Strengths and Difficulties Questionnaire and the Rosenberg Self-Esteem Scale, to ascertain coping strategies and mental health problems for these young people, which will be compared with normative population samples. Smaller groups of children and parents will be involved in in-depth qualitative interviews to explore the impact of parental imprisonment and support services available in greater detail. Interventions to support these families will be comprehensively mapped. Children will play a prominent role in disseminating research results to policy makers and professional bodies Impacts of the COPING research will include improvements in information about this group of children; step changes in Government and public awareness about their plight; potential new legislation; and improvements in prison regimes to enable effective contact and visits for children to imprisoned

Keywords: children of prisoners,inteventions and mitigations to strengthen mental health