Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling Global-Scale Mine-Level Indicators from Satellite Observations (MINE-THE-GAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The global surge in mining, driven by decarbonisation and digitalisation, has uncovered a critical gap in our understanding of its environmental and social impacts and risks. Despite the seemingly abundant knowledge about mining operations, they remain largely unmeasured, even within the European Union, posing a challenge to sustainable development efforts. Essential indicators, such as geographical locations, waste generation, and details of extracted minerals and commodities, are surprisingly scant worldwide. Satellite images and artificial intelligence algorithms are prominent technologies to fill this knowledge gap. However, scaling the mapping of mining indicators to the global level remains a challenge due to the small size and low quality of training sets. The MINE-THE-GAP project will lay the foundations of an innovative methodology to scale up the production of mine-level indicators. Methodologically, the project presents a breakthrough by integrating high-precision data products from various satellite sources to substantially enrich training sets that will enable the creation of scalable artificial intelligence models to effectively map mine land use, waste generation, and types of extracted minerals and commodities. This approach will allow the production of mine-level indicators that are timely, locally relevant, and globally reliable, and ensure the continuous improvement of models beyond the project's timeline as new high-precision data becomes available. For the first time, MINE-THE-GAP will unlock new avenues in sustainability research, overcoming previous obstacles due to the lack of essential geoinformation on mining. The project will create the basis for scalable mining site monitoring, essential for enforcing European supply chain transparency laws and achieving the United Nations' Sustainable Development Goals.
PReclinical EVAluation and Investigation of Laterocidamide - A novel antibiotic from a new drug class to overcome polymyxin resistance. (PREVAIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The emergence of Gram-negative bacterial resistance against antibiotics, especially the last-line-of-defense polymyxins, presents a societal threat with the potential to inflict higher healthcare costs and life-threatening patient risks. For decades, physicians have relied on polymyxins as a last line of defense to treat resistant Gram-negative bacterial infections that do not respond to standard antibiotic therapies. However, in 2016, a new polymyxin resistance mechanism surfaced: mobilized colistin resistance (MCR-1). The global overuse of antibiotics, including polymyxins, and a persistent lack of novel antibiotics have made us vulnerable to increased bacterial resistance, including the MCR-1 strains, seriously threatening our public health. In Project PREVAIL, our group will validate the effectiveness of a novel drug, Laterocidamide (LATERO), from a new class of antibiotics to deliver an innovative solution that can mitigate the alarming global surge of antibiotic resistance. Our novel synthetic antibiotic, LATERO, has best-in-class potential to address these challenges with (i) minimal antimicrobial resistance, (ii) Gram-negative bacterial efficacy against polymyxin-resistant strains, and (iii) the ability to be produced at low cost. Moreover, our robust synthetic approach will allow us to generate additional analogs in the future. In PREVAIL, we will explore LATERO's technical and commercial potential. Specifically, we will validate LATERO as a novel antibiotic for (multi-drug-resistant) Gram-negative bacterial infections by performing in vitro and in vivo efficacy and preclinical toxicity studies. In parallel, we will: 1. Analyze the IP position and develop an IP rights strategy to protect LATERO and new analogs developed in the project to secure future assets. 2. Evaluate LATERO’s commercial feasibility and construct viable business cases to enter the market to support outreach and procuring future funding opportunities.
Advanced Processes Enabling Low cost and High Performing Large Scale Solid Oxide Electrolyser Production (PilotSOEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Denmark,Estonia,Finland,Latvia,Slovenia
Call: Design for advanced and scalable manufacturing of electrolysers (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 6
Project status: SIGNED

PilotSOEL will develop and demonstrate SOEL cells and stacks for high-current operation, applying advanced scalable manufacturing processes to enable SOEL production at much lower cost than for today’s state-of-the-art (SoA) products. The project will focus on innovative upscalable and low-cost SOEL component manufacturing processes with reduced use of Critical Raw Materials (CRM) and waste recycling in the cell production processes, and increase the degree of automation in the stack assembly to reduce manufacturing cost. The project will develop a novel environmentally friendly water-based tape casting process with a reduced number of process steps for half-cell production. Innovative thin protective barrier layers deposited by ALD and PVD, together with microstructural cell optimisation, will reduce the cell resistance, improving the cell performance and durability at high current operation. The dense and thin coating made by PVD will improve the oxidization resistance of the interconnector, allowing the use of cheaper alloys, and ensuring a long stack lifetime. A life-cycle assessment (LCA) and a techno-economic analysis (TEA) will be performed to benchmark the developed processes in PilotSOEL with the SoA SOEL production processes. The project is aiming to improve the SOEL processing MRL from MRL 4 at the beginning of the project to at least MRL 5 at the end of the project. The PilotSOEL consortium is formed by experienced industries and research partners with complementary competences and well-defined roles in the project, including cell and cell component development (DTU, ELCAS, Naco, Beneq), interconnector coating development (Naco, ELCOY), stack development and stack assembly process automation (ELCOY), performance validation (DTU), and finally LCA/TEA (UL) of SOEL manufacture. PilotSOEL will ensure the competitive position of key European industries/SMEs in the rapidly growing world market for electrolysis technology, taking the leadership in this area.

Keywords: soel,soec,solid oxide electrolysis,manufacturing,soel stack
PHYGITAL SOLUTIONS FOR THE CULTURAL AND CREATIVE INDUSTRIES (AMPLIFY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Spain,Portugal,Italy,United Kingdom,Netherlands,Ireland,Norway,France
Call: Leverage the digital transition for competitive European cultural and creative industries (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4304720.89
EU funding (EUR): 3985884.79
Participants: 14
Project status: SIGNED

AMPLIFY is a consortium of artists, technologists and researchers from 8 European countries dedicated to facilitating the digital transition in the Cultural and Creative Industries (CCIs). It rests on three ideas: a) Music is humanity’s universal and transversal non-verbal language, enriching many CCI sectors; b) Physical–digital (phygital) experiences enrich the CCI offer with new opportunities; c) Impactful social value stems from co-creation by both professionals and non-professionals. AMPLIFY will develop, test and pilot two innovative suites of digital technologies empowered by AI and XR for CCIs. AMPLIFY PORTABLE is a cost-effective, easy-to-use tool to facilitate people in different places to play, learn and perform together, especially at community level. AMPLIFY IMMERSIVE enables producers to promote live performance experiences to distributed and remote audiences. Both tools will be open-source and, although focused on music, transferable across the spectrum of CCI sectors. AMPLIFY’s technology will be developed and tested with a diverse range of creative partners and situations in four small-scale pilot trials: 1) RENEWING TRADITION: Remote learning and performance in Gaelic folk culture (UK); 2) MUSIC WITH BABIES: Digitally-enabled music co-creation with families (PT); 3) STAGE DIVING: Augmented Reality concerts connecting artists and audiences (IT); 4) REVEALING OPERA: Immersive experiences of co-creation with communities (ES). The project will involve other CCI sectors from the start, explore their needs, desires and fears about the digital transition, and generate added value as early as feasible. AMPLIFY rests on a human-centric approach that balances the tools and their use, so that the whole project delivers not only innovative technologies, new ways of working and enhanced audience experiences, but also sustainable economic models consistent with the beliefs, values and practices of the creators and audiences for wider societal benefit.

Keywords: cci,digital transformation,ar xr,artificial intelligence,phygital,music
Holistic heat energy management on ships by implementing innovative dynamic calculation models towards maximum waste heat capture and energy efficiency (HEMOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Estonia,Sweden,Italy
Call: Innovative on-board energy saving solutions (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-05-01
End date: 2025-09-30
Duration (months): 41.0
Total project cost (EUR): 4733700.0
EU funding (EUR): 4733699.0
Participants: 4
Project status: SIGNED

The project aims to decarbonize EU’s fleet by improving ship’s heat energy system through optimization of heat flow topology with dynamic calculation model, as well as including latest advancements in heat energized technologies. In this project all major consumers, heat producers and waste heat sources are considered. Furthermore, the calculation model is planned to be validated by real-life on-board prototype, to go further from theoretical calculations and experience. Thus creating a new innovative approach towards design method of heat energy system on the ships. The main target is to reach 14% efficiency increase by the calculation and scale it down to prototype to validate. The project is divided into three phases. First phase is concentrated on researech and development of the calculation tool based on the collected on-board data from the case study ship, with an outcome of new heat energy system topology with best efficiency based on limitations given by the ship owner. The second phase continues with development of process and system engineering for the optimized system arrangement, with an outcome of initial automation and interface principles. Third phase is a practical installation of prototype on board of the case study ship and validation of the calculation model vs real installation. The validation will impact shipowners perception on the possibilities to upgrade their ships. Additionally will provide valuable experience to participating parties to strengthen EU companies position on the market with high-end technology and heat energy efficiency optimization on ships. The efficiency increase will help to reduce ship emissions in CO2; NOx; SOx and particulate matter which is getting critical from EU enviromnental strategies.

Keywords: energy saving,decarbonization,orc,energy efficiency,net zero,vessel
A MISTery of Long Secondary Periods in Pulsating Red Giants - Traces of Exoplanets? (LSP-MIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1380760.0
EU funding (EUR): 1380760.0
Participants: 1
Project status: SIGNED

Exoplanetary science is one of the most studied and challenging areas of modern astrophysics. Various planet detection techniques allowed astronomers to discover over 4,500 extrasolar planets in our Galaxy, providing important constraints for testing planet formation theories. However, with the currently available methods, it is still impossible to find planets in the far regions of the Milky Way and in other galaxies. In consequence, we still cannot answer fundamental questions of exoplanetary science such as: how are planets distributed in our and other galaxies, and how does their occurrence rate depend on the chemical content and density of their environments? Therefore it is urgent to find a new method of planet detection that will allow us to discover faraway planets and thus open new horizons for exoplanetary studies. Here I propose to develop such a method. I will use a class of abundant bright giant stars that exhibit long secondary periods (LSPs) as traces of extrasolar planets. These stars are binary systems, in which the companion is substellar and is submerged in a dusty cloud. The hypothesis is that the companion is a former planet that accreted enough matter from the host star to become a brown dwarf. I will use the high quality photometric and spectroscopic data of LSPs from large-scale surveys and combine them with modern hydrodynamical simulations to verify this hypothesis. If successful, the novel method will revolutionise the field of exoplanet detection, by allowing to find extrasolar planetary systems beyond our neighbourhood, and especially in other galaxies, which is impossible with the current techniques. In the next step, I will apply this novel method to hundreds of thousands of LSP variables from the OGLE catalogs of the Milky Way and the Magellanic Clouds to investigate the distribution of planets in different chemical and dynamical environments, and thus provide completely new constraints for planet formation theories.

Keywords: long period variable stars asymptotic giant branch stars exoplanet detection methods star planet interactions
Static and Dynamic aproaches: A Unified Framework for Predicting Quantum Yields of Excited State Processes (StanDUP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: CLOSED

Light is at the heart of many critical processes, from photon-to-energy conversion to photosynthesis. Common among those fields is that, upon excitation, a molecule has to release energy to return to the ground state. However, deciphering how molecules release this energy is a complex puzzle involving navigating a maze of all the possible deactivation pathways. As more excited states and photoproducts are involved, this puzzle becomes more intricate. All these pathways compete, and the excited-state decay rates dictate the entire photochemistry of the system. To advance light-related applications, we must unravel and map these possibilities. For the same system, we could have thermally and non-thermally equilibrated processes taking place, as well as competing processes spawning from a few femtoseconds up to seconds, thus encompassing this entire spectrum of processes remains a formidable challenge in computational chemistry, demanding radically different approaches: the static and dynamic approaches. In this project, I face this challenge by combining diverse strategies for computing decay rate constants in excited states. The overarching objective is constructing a unified framework that seamlessly merges static and dynamic methodologies. This integration will enable predictions of crucial parameters like fluorescence quantum yields and lifetimes. The roadmap to success involves the development of two distinct protocols. In the integrated-based protocol, I will combine excited-state decay rate theories and nonadiabatic dynamics to accurately compute individual decay rate constants. In the independent-based protocol, I will explore the independent utilization of static and dynamic approaches to compute rates independently, subsequently synthesizing these data to understand photochemical behavior. This proposal is poised to revolutionize our comprehension of photochemical processes, transcending the boundaries of current state-of-the-art methodologies.

Keywords: nonadiabatic dynamics,excited state decay rate theories,wavefunction descriptors
Residual disease assessment in hematologic malignancies to improve patient-relevant outcomes across Europe (RESOLVE) (RESOLVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Italy,Spain,Greece,Israel,France,Poland
Call: Pragmatic clinical trials on minimally invasive diagnostics (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 8000000.0
EU funding (EUR): 8000000.0
Participants: 23
Project status: SIGNED

Measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) has strong prognostic value in patients with the most frequent acute and chronic leukemias, acute myeloid (AML) and chronic lymphocytic leukemia (CLL), but it has not yet been confirmed as a treatment-guiding biomarker. The RESOLVE Consortium will leverage numerous existing expert networks and patient advocacy partnerships to establish the predictive value of MRD in AML/CLL patients, with the expectation that this affordable, minimally-invasive biomarker can be imminently used to guide the intensity of consolidation therapy, improve quality of life (QoL), and reduce costs. This will be achieved through 1) development of a real-world patient registry and data platform; 2) establishment of standardized, decentralized MRD analysis across Europe; and 3) a randomized, controlled multi-national pragmatic trial based on the hypothesis that treatment intensity can be safely reduced in MRD negative AML/CLL patients, to provide evidence for the clinical, personal and societal impact of MRD-guided therapy. These efforts will be supported by RESOLVE’s participatory research pipeline, which will incorporate input from patients, caregivers, and experts in social sciences and health economics. The real-world nature of the study ensures broadly applicable results for all patients regardless of location, socioeconomic status, gender, sex, disability or ethnicity. The findings will then be effectively communicated and disseminated following open science principles through the medical community for uptake in routine clinical practice. The laboratory, clinical, and patient advocacy infrastructures already in place will support rapid adoption of MFC-based MRD assessment to aid in clinical decision-making. The Consortium’s widespread member organizations will work with policymakers and authorities across the EU to provide access to the test in the national health care systems for all AML and CLL patients. This action is part of the Cancer Mission cluster of projects "Diagnostics and Treatment (diagnostics)".

Keywords: mrd,biomarker,aml,cll,pragmatic trial,patient empowerment,hta,digital medicine,living labs