Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild (MitoWild)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 2445128.75
EU funding (EUR): 2445128.75
Participants: 1
Project status: SIGNED

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

Keywords: metabolic rate,mitochondria,ecophysiology,ecology,competition
Minimal Model for Pox-Virus Infection (MMXVI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of biological systems including other viruses. Thereby, this proposal looks to advance the field of infection biology into the nanoscale.

Keywords: virus host interaction,membrane organization and dynamics,super resolution microscopy,single particle tracking
Large Passenger Aircraft (LPA GAM 2018)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Spain,Italy,Germany,Germany,Italy,Norway,Norway,Belgium,Poland,Poland,Romania,Sweden,Sweden,France,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Large Passengers Aircraft (H2020-IBA-CS2-GAMS-2017, 2017)
Start date: 2014-01-09
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 247978162.58
EU funding (EUR): 184973049.81
Participants: 73
Project status: CLOSED

The challenge for Clean Sky 2's Large Passenger Aircraft Programme is to further mature and validate key technologies such as advanced wings and empennages design, making use of hybrid laminar airflow wing developments, as well as an all-new next generation fuselage cabin and cockpit-navigation.

Keywords: large aircraft,wing design,cockpit and cabin design
Black Liquor to Fuel by Efficient HydroThermal Application integrated to Pulp Mill (BL2F)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Research and Innovation actions
Countries involved: Germany,Finland,Switzerland,Norway,Finland,France,Czechia,United Kingdom,Portugal,Portugal
Call: Development of next generation biofuel and alternative renewable fuel technologies for aviation and shipping (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 4999623.75
EU funding (EUR): 4999623.75
Participants: 13
Project status: SIGNED

Black Liquor to Fuel (BL2F) process produces drop-in biofuels for aviation and shipping from black liquor, a side stream of chemical pulping industry. 83 % CO2 reduction compared to fossil fuels, and competitive production cost of 0.90 €/l for drop-in sustainable aviation fuel are received. A large deployment, using a variety of biomass, can yield >50 billion liters of advanced biofuels by 2050, then satisfying the EU demand for advanced biofuels for aviation (15 Mtoe) and shipping (30 Mtoe). First-of-a-kind Integrated Hydro Thermal Liquefaction (IHTL) process at pulp mills produces fuel intermediate for further upgrading in oil refineries. Biomass is converted to low oxygen content (< 10 w-%) HTL-oil in water of reductive conditions at up to 400 ˚C, 300 bar. The expected energy yield is >85 %. Integrated hydrothermal HydroDeOxygenation (IHDO) will further upgrade HTL-oil to fuel intermediate (< 5 w-% O2), classifying as bunker-like marine fuel or feedstock for high-quality aviation and marine fuels production. The process innovations of BL2F are: 1) combined salt separation and HTL-reactor, enabling direct upgrading of HTL-oil, 2) reforming of the aqueous phase to hydrogen, decreasing the need for external fossil hydrogen in IHDO, 3) integrating the process to pulp mill, offering cost reductions in treating of the gaseous and solid side streams by existing process installations. The BL2F is supported by CEPI, Avinor, and Rolls Royce and covers the whole value chain: The 6th largest producer in the world of bleached eucalyptus kraft pulp NVG, the leading biorefinery supplier Valmet, catalyst developer Ranido and Neste, the world’s largest producer of renewable diesel collaborate with excellent research partners; VTT, PSI, SINTEF, Tampere University, KIT, Brunel University London. LGI and industrial partners maximize the impact of the project. The ambitious goals and strong consortium strengthens European leadership in renewable biofuels and climate protection.

Keywords: aviation,shipping,drop in advanced biofuel,hydrothermal liquefaction,black liquor,integrated,sustainability
The invisible city. Mapuche mapping of Santiago de Chile. (MAPS-URBE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Chile
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2020-12-08
Duration (months): 36.0
Total project cost (EUR): 233811.0
EU funding (EUR): 233811.0
Participants: 2
Project status: CLOSED

The proposed research explores experiences of urban space among young indigenous Mapuche living in Santiago de Chile, in order to make visible indigenous subjects whose daily lives, collective concerns and social circumstances are often relegated to the margins of policy making and public interest. It seeks to research the impact of displacement and social exclusion on indigenous youth, as well as offer a means of intervention. The project will identify a set of mutually negotiated research aims alongside young Mapuche, developing a series of collaborative and participatory methods, including mapping, video and exhibition making, to offer a better understanding of indigenous experiences of the city as a kind of “in betweeness” - as expressed by the term Mapurbe, from mapu (earth) and urbe (city) - used to symbolize the on-going negotiation of marginality and displacement from the ancestral territory. The outcome of the collaborative research will be used to address the relationship with non-Mapuche citizens through two exhibitions (in Chile and Europe), offering young Mapuche an opportunity to make an active intervention into public discourse. The proposed research thus aims to apply theoretical knowledge, collaborative methods and modes of representation to issues of critical social interest in ways that are directly applicable to other context within Latin America and across Europe. The necessary training-through-research will be at the Instituto de Estudios Urbanos y Territoriales - Pontificia Universidad Católica (Chile), and at the Granada Centre for Visual Anthropology - University of Manchester (UK). This will provide the researcher with theoretical and technical competencies in Urban Studies and Visual Anthropology. The proposed research will contribute to the strengthening of European networking at an interdisciplinary and inter-continental level, building an international dialogue that will have positive and practical impacts on the European Research Area.

Keywords: mapuche,mapurbe,urban indigenous,santiago,chile,biographical method,storytelling,placemaking,walking,participatory mapping,collaborative methods,empowerment,visual anthropology
NEurobehavioural predictiVE and peRsonalised Modelling of depressIve symptoms duriNg primary somatic Diseases with ICT-enabled self-management procedures (NEVERMIND)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Italy,Italy,Sweden,United Kingdom,Portugal,United Kingdom
Call: Self management of health and disease and decision support systems based on predictive computer modelling used by the patient him or herself (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-01-01
End date: 2020-09-30
Duration (months): 57.0
Total project cost (EUR): 4999513.75
EU funding (EUR): 4999513.75
Participants: 9
Project status: CLOSED

Personal health systems for the management of chronic diseases have seen giant leaps in development over recent years. These systems offer vital sign monitoring and therapy delivery at home, focusing on the primary physical disease conditions. However, they do not provide support for early mood assessment or psychological treatment and lack a real-time comprehensive assessment of the patient’s mental status. Depression is the third leading contributor to global diseases, and depressive mood state is also considered to be strictly related to the onset or worsening of a severe primary somatic disease. Indeed effective preventive medicine related to the onset of depressive symptoms as a comorbidity and worsening factor of psychosomatic diseases such as myocardial infarction, leg-amputation, cancer, and kidney failure is lacking. NEVERMIND sets out to empower people who suffer from symptoms of depression related to a serious somatic disease by placing them at the center of their mental healthcare. Equipped with just a smartphone and a lightweight sensitized shirt, patients seeking care and treatment for their mental illnesses interact with these devices that collect data about their mental and physical health, to then get effective feedback. Lifestyle factors, i.e. diet, physical activity and sleep hygiene, play a significant mediating role in the development, progression and treatment of depression, and in NEVERMIND will be monitored by a real-time Decision Support System running locally on the patient’s smartphone, predicting the severity and onset of depressive symptoms, by processing physiological data, body movement, speech, and the recurrence of social interactions. The data will trigger a response encouraging the patient to conduct or alter activities or lifestyle to reduce the occurrence and severity of depressive symptoms. The final aim is to bring this system to the market, giving people the tools to control their depression and unburden their minds.

Keywords: wearable monitoring system,autonomic nervous system dynamics,somatic disorders in comorbidity with depression,biomedical signal processing,mood state prediction,heart rate variability
Alzheimer’s disease and AAV9: Use of a virus-based delivery system for vectored immunoprophylaxis in dementia. (AD-VIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Alzheimer’s disease (AD) is the most common form of dementia in the Western World, representing an economic and social cost of billions of euros a year. Given the changing demographics of society, these costs will only increase over the coming decades. Amyloid plaques, composed of amyloid beta peptide (Abeta), are a defining characteristic of AD. Evidence now suggests that Abeta is central to disease pathogenesis due to its toxicity, which leads to cell loss and eventual cognitive decline. Abeta is generated by proteolytic cleavage of amyloid precursor protein, a process that involves the protein BACE1. Knock-down of BACE1 is sufficient to prevent amyloid pathology and cognitive deficits in transgenic mouse models of AD, so BACE1 is an attractive target for therapeutic intervention. Although many small molecule inhibitors of BACE1 have been developed, many have problems with imperfect selectivity, posing a substantial risk for off-target toxicity in vivo. In contrast, antibody-based therapeutics provide an attractive alternative given their excellent molecular selectivity. However, the success of antibody therapies in AD is limited by the blood brain barrier, which limits antibody entry into the brain from the systemic circulation. Recent studies have shown that adeno-associated virus serotype 9 (AAV9) effectively crosses the blood brain barrier. Here, we propose evaluating the use of AAV9 as a delivery system for a highly specific and potent inhibitory nanobody targeted against BACE1 as a treatment for AD.

Keywords: adeno associated virus aav based vector,blood brain barrier crossing,nanobody,bace1
Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources (MediHealth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: South Africa,Austria,Germany,Switzerland,Switzerland,Tunisia,Belgium,Greece,Greece,France,Chile,Viet Nam
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 1224000.0
EU funding (EUR): 1224000.0
Participants: 13
Project status: CLOSED

The main goal of the MediHealth project is to introduce a novel approach for the discovery of active agents of food plants from Mediterranean diet and other global sources to promote healthy ageing. This will be achieved through an extended and well-balanced scheme of researcher’s secondments between 5 universities and 4 enterprises from EU & Associated countries as well as 4 universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing complementary expertise will be the base of this proposal. Plants from the Mediterranean diet and food plants from TC will be rationally selected and will be subjected to an integrated, interactive and comprehensive platform including in silico, in vitro (advanced cell-based assays), in vivo (flies and mice models) & metabolism assessment. Advanced analytical techniques will embrace the pharmacological evaluation process for the efficient isolation and identification of bioactive plant constituents. Pharmacological profiling of bioactive natural products as well as identification and synthesis of their metabolites will be carried out. Finally, to carry to the stage of development innovative products in the area of nutraceuticals/dietary supplements process-optimization studies will be performed. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). MediHealth aspires to comprise a successful model promoting considerably researchers’ competences and long-lasting collaboration between Industry and Academia generating innovation potential at the European and global levels.

Keywords: food plants,diet,aging,metabolic syndrome,phytochemistry,natural products,metabolism,analytics,extraction,isolation
BigStorage: Storage-based Convergence between HPC and Cloud to handle Big Data (BigStorage)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Spain,Ireland,Germany,Spain,Greece,France,France,France,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3803407.92
EU funding (EUR): 3803407.92
Participants: 13
Project status: CLOSED

The consortium of this European Training Network (ETN) "BigStorage: Storage-based Convergence between HPC and Cloud to handle Big Data” will train future data scientists in order to enable them and us to apply holistic and interdisciplinary approaches for taking advantage of a data-overwhelmed world, which requires HPC and Cloud infrastructures with a redefinition of storage architectures underpinning them - focusing on meeting highly ambitious performance and energy usage objectives. There has been an explosion of digital data, which is changing our knowledge about the world. This huge data collection, which cannot be managed by current data management systems, is known as Big Data. Techniques to address it are gradually combining with what has been traditionally known as High Performance Computing. Therefore, this ETN will focus on the convergence of Big Data, HPC, and Cloud data storage, ist management and analysis. To gain value from Big Data it must be addressed from many different angles: (i) applications, which can exploit this data, (ii) middleware, operating in the cloud and HPC environments, and (iii) infrastructure, which provides the Storage, and Computing capable of handling it. Big Data can only be effectively exploited if techniques and algorithms are available, which help to understand its content, so that it can be processed by decision-making models. This is the main goal of Data Science. We claim that this ETN project will be the ideal means to educate new researchers on the different facets of Data Science (across storage hardware and software architectures, large-scale distributed systems, data management services, data analysis, machine learning, decision making). Such a multifaceted expertise is mandatory to enable researchers to propose appropriate answers to applications requirements, while leveraging advanced data storage solutions unifying cloud and HPC storage facilities.

Keywords: big data,data science,storage,cloud,energy