Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lands of Meaning. A Geographical Information System Study of Space and Social Praxis in Ancient Attika, Greece, from the Mycenaean Age to the birth of Democracy (1200-480 BC) (LandsOfMeaning)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The proposal aims at considering space in Ancient Greece as a true ‘land of meaning’. Ancient Attika, in particular, constitutes a highly heuristic observatory of the continually evolving social identities during the period from the final period of the Mycenaean palaces until the Classical Age (1200-480 BC). In fact, many aspects of these historical processes are currently poorly understood, because no strong link to spatial analysis has ever been attempted. We are dealing with a period during which material investment leads to the creation of spaces for living that are less mobile, thus increasing the advantages of clustered ‘urban’ life and enabling a changing economy with wider opportunities for regular exchange in networks of contacts with the outer world by exploiting a well-known landscape. Subject of the research are space, places and social patterns in this area of Ancient Greece, of a paramount importance for the history of the ancient Mediterranean and the modern world. Important questions are still present as ever, concerning the birth, evolution and negotiation in time of regional and sub-regional identities, the formation of territorial compounds, monumental public and religious architecture, along with the subjacent societal constructions, such as the birth of citizenship and democracy. A new approach is much needed. The use of cutting-edge digital mapping technologies (Geographical Information System, GIS) and still under-exploited innovative theoretical frameworks such as spatiology will enable a new systemic contextualisation of the available archaeological and textual evidence. The outcome will be a better understanding of the cultural, political and symbolic dynamics, in their continuous reiterations and reinventions through space and time as evolved in ancient Athens, which still inspires the European imaginary. Therefore, the project owes its timely conception to similar concerns of the modern world, which is ill at ease in its priorities.

Keywords: ancient greece,attika,archaeology,history,geographical informaton system,regional study,evolution of complex societies,settlements,social processes,bronze,iron,archaic and classical age
Industrial Design Easy Assembly Kit (IDEA.k)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Italy
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

China is the main worldwide manufacturer of packaging machinery with around the 23% of the market share and almost a complete control of the affordable machinery sector. Its competitiveness is based on low prices supported by its inherent minor labour costs. This situation has pushed the reduction of the European market share from around 45% by 2007 to the current 20% nowadays with a total loss of the low-end segment. In order to recover this lost of competitiveness, Mac Due has been developing a new business model for the packaging machinery sector which pivots on the sales of equipment as assembling kits. This manner, the assembling cost are transfered to the regional dealers and automatically adjusted to the destiny country, circumventing the labour cost issue while it keeps the manufacturer margin profit. Besides, the dealers' role is upgraded to become the providers of post-sale services and maintenance, generating new revenues streams for them. This impact is finally translated to the end-user which can obtain savings of up 35% thanks to the previous cuts. With this project, Mac Due aims to offer a reliable alternative to the European packaging machinery sector whose success will open new opportunities to the whole machinery industry.

Keywords: packaging,machinery,assembling,business,model
Imperial Queers, Republican Subjects: The Politics of Queer Historiography in Turkey (IQRS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 145355.52
EU funding (EUR): 145355.52
Participants: 1
Project status: CLOSED

Historiography has played a crucial role in nation-building projects across the world and Turkey presents a striking example of this phenomenon. In the country’s formative years (1923-1938), while the government took measures to create an official formulation of Ottoman and Turkish history, dissident groups across the political spectrum produced its alternatives. In both hegemonic and alternative historiography projects, gender and sexuality were of key significance. This research analyzes the politics of queer historiography and archival practice in this period by focusing on the works of three intellectuals: Hüseyin Rahmi Gürpınar (1864-1944), Reşad Ekrem Koçu (1905-1975), and Rıza Nur (1879-1942). The project examines how these prominent queer figures, who were born in the Ottoman Empire and witnessed the emergence of the nation-state, produced alternative and queer formulations of the past in the service of Marxist, neo-Imperialist, and fascist ideologies as they negotiated the politics of citizenship and belonging. To understand these processes, the project uses multi-sited archival research, and presents critical biographies of the authors together with close readings of the texts and performances they created. As the first comprehensive study on queer historiography and archival practice in Turkey, this research brings a new perspective to the sexual dimensions of nation-building. With the aid of ethnography, the project also analyzes the current efforts to redefine the official formulation of Turkey’s history, and how the works of queer intellectuals continue to influence both mainstream and alternative historiographical projects in the country. The project thus challenges some of the popular trends in Ottoman and Turkish historiography, especially the gendered and sexualized aspects of oral history projects as well as their ramifications on the current historical justice efforts—including the Armenian Genocide.

Keywords: sexuality,gender,turkey,historiography,citizenship
HOME INTEGRATED RENOVATION ONE-STOP-SHOP FOR VULNERABLE DISTRICTS (HIROSS4all)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Belgium
Call: Integrated home renovation services (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-05-10
End date: 2023-01-09
Duration (months): 44.0
Total project cost (EUR): 1786766.25
EU funding (EUR): 1786766.25
Participants: 9
Project status: CLOSED

HIROSS4all Project will develop and implement an innovative integrated home renovation service (IHRS) for private residential buildings in two districts in the Basque Country (Spain) and subsequently replicated within the region. The project develops an economically viable business model that brings together active citizen engagement and an innovative financial instrument, making the service suitable for vulnerable populations. The local one-stop-shop pilots will be managed and coordinated by the Basque Government. Specific objectives: -Foster energy efficiency building upgrades, on vulnerable districts. -Minimize logistical, financial, administrative and legal burdens caused by a complex and multi-stakeholder home renovation process -Ensure that building retrofits consider the social dimension by incorporating security, comfort, and improved accessibility for Basque citizens to further improve the quality of life of vulnerable population. -Design a scalable operating model to the district offices, and ensure the replicability of the one-stop-shop service, at both the Basque Country and the EU-level. -Create strong and reliable public-private partnerships for the provision of the service. - Identify and overcome regional-local collaboration barriers inherent to home renovation services. -Increase homeowner and regional partner awareness of the multiple benefits of energy efficiency, including health, wellbeing, comfort, job creation and energy poverty alleviation. For achieving this issue a consortium consisting on 9 partners (GV, EVE, GNE, DEBEGESA, VVMM, FEDARENE, ZABALA, G6 and HOUSING-EU) has been assigned. It is a well-balanced group with different backgrounds and complementary expertise and skills, covering the full value chain.
Development of Kinetoplastida Flap Endonuclease Inhibitors in Search for Novel Therapeutics (FEN INHIBITORS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2023-01-31
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: CLOSED

We are searching for Kinetoplastida flap endonuclease (FEN) inhibitors as a base for potential therapeutics for parasite infections, for which there is significant unmet clinical need. Kinetoplastida are flagellated protists responsible for 3 neglected human diseases. We will target the FEN enzymes from Trypanasoma cruzi and Leishmania species, the organisms causing Chagas disease and leishmaniaisis respectively. FEN activity is crucial for the survival of all organisms tested so far from mouse to bacteria, including Trypanosoma. We will identify specific inhibitors of Kinetoplastida FENs as the basis for future development of urgently needed new therapeutics. This multidisciplinary structure-based inhibitor design project will involve in vitro and in silico screening, protein crystallization, rounds of inhibitor design and finally in vivo potency and toxicity experiments. The project will be overseen by Prof Sayers who has 30 years of experience with nucleases and who has founded two spin-out companies. His group is complemented through collaboration with a parasitologist Dr Helen Price (20 years research experience), who has been actively involved in developing antiparasitic agents. The experienced researcher, who has a strong protein biochemistry and crystallography background, is returning to academic research after almost 4 years outside science. Ultimately, the experienced researcher is aspiring to an academic career in translational medicine rooted in state-of-the-art basic research but with the skills and experience to synergise with the pharmaceutical sector.

Keywords: inhibitor assay screening,docking,virtual high throughput screening,nuclease inhibitors,mechanistic enzymology,in vivo toxicity experiments,antiparasitic agents,neglected tropical diseases
The Quest of the Argonautes - from Myth to Reality (ARGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 2177157.5
EU funding (EUR): 2177157.5
Participants: 1
Project status: SIGNED

Argonaute nucleases are key players of the eukaryotic RNA interference (RNAi) system. Using small RNA guides, these Argonaute (Ago) proteins specifically target complementary RNA molecules, resulting in regulation of a wide range of crucial processes, including chromosome organization, gene expression and anti-virus defence. Since 2010, my research team has studied closely-related prokaryotic Argonaute (pAgo) variants. This has revealed spectacular mechanistic variations: several thermophilic pAgos catalyse DNA-guided cleavage of double stranded DNA, but only at elevated temperatures. Interestingly, a recently discovered mesophilic Argonaute (CbAgo) can generate double strand DNA breaks at moderate temperatures, providing an excellent basis for this ARGO project. In addition, genome analysis has revealed many distantly-related Argonaute variants, often with unique domain architectures. Hence, the currently known Argonaute homologs are just the tip of the iceberg, and the stage is set for making a big leap in the exploration of the Argonaute family. Initially we will dissect the molecular basis of functional and mechanistic features of uncharacterized natural Argonaute variants, both in eukaryotes (the presence of an Ago-like subunit in the Mediator complex, strongly suggests a regulatory role of an elusive non-coding RNA ligand) and in prokaryotes (selected Ago variants possess distinct domains indicating novel functionalities). After their thorough biochemical characterization, I aim at engineering the functionality of the aforementioned CbAgo through an integrated rational & random approach, i.e. by tinkering of domains, and by an unprecedented in vitro laboratory evolution approach. Eventually, natural & synthetic Argonautes will be selected for their exploitation, and used for developing original genome editing applications (from silencing to base editing). Embarking on this ambitious ARGO expedition will lead us to many exciting discoveries.

Keywords: argonaute,rna interference,rnai,crispr,mediator,protein design,laboratory evolution,genome editing
Cerebellar circuits for locomotor learning in space and time (LOCOLEARN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Portugal
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

Every movement we make requires us to coordinate our actions precisely in space and time. This proposal aims to understand how that remarkable coordination is achieved by neural circuits controlling movement. The cerebellum plays a critical role in keeping movements calibrated and coordinated, and it is thought to do this in part through a motor learning process in which predictable perturbations of movement are gradually compensated. Cerebellum-dependent forms of motor learning have been identified for a variety of behaviors, including locomotion, and locomotor learning is used as a rehabilitative therapy in human patients. We recently established locomotor learning in mice, using a custom-built, transparent split-belt treadmill that controls the speeds of the two sides of the body independently and allows for high-resolution behavioral readouts. Here, we will combine quantitative analysis of locomotor behavior with genetic circuit dissection to answer two fundamental questions: How are cerebellar outputs read out by downstream circuits, to calibrate spatial and temporal components of movement? and How are instructive signals for spatial and temporal learning encoded by cerebellar inputs? Specifically, we will: 1) Use circuit tracing combined with manipulation of specific cerebellar outputs to identify downstream pathways for spatial and temporal locomotor learning, 2) Investigate the role of error signals for cerebellar learning via optogenetic perturbation of climbing fiber inputs to the cerebellum, and 3) Image complex spike activity from populations of Purkinje cells during locomotion and learning, to ask how spatial and temporal error signals are encoded within the cerebellum. These studies will allow us to bridge levels of analysis to understand how cerebellar learning mechanisms convert behaviorally-relevant sensorimotor error signals into calibration signals that ensure accurate and coordinated movements in space and time for a wide range of behaviors.

Keywords: cerebellum,motor learning,neural circuits,locomotion,mouse
Modulating ice nucleation and growth with bio-inspired protein-polymers for cryopreservation (PROTECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1999535.0
EU funding (EUR): 1999535.0
Participants: 1
Project status: SIGNED

Efficient, non-toxic cryoprotectants, that allow long-term storage of viable therapeutic cells and tissues, are the tool that regenerative medicine requires for its successful realization into a viable therapeutic option. A remarkable class of biopolymers known as ice-binding proteins (IBPs) alleviate the risk of freeze injury throughout the Kingdoms of Life by keeping the nucleation and growth of ice crystals in check. Yet, the application potential of IBP analogues (IBPAs) as cryoprotectants has remained underexploited. This is because we are yet to unravel and utilize the structure-function relations, which govern the activity of IBPAs as inhibitors of ice recrystallization and promoters of ice nucleation at the single-molecule level in vitro and within a complex biological environment. I propose to develop uniquely modular IBPAs to perform the quantitative single-molecule and physico-chemical experiments essential to bridge this knowledge gap and to engineer ice-binders optimized for cryopreservation. Our first aim is the biosynthesis of a novel class of ice-binding protein-polymers (iPP) with systematic variations in composition and size. Ice nucleators with a broad range of sizes will be created from iPPs of variable chain length by dissolution, self-assembly and surface-tethering to nanoparticles of variable dimensions. Super-resolution microscopy experiments of iPP ice-binding will deliver high-resolution maps of spatiotemporal distribution and dynamics. These will be related to iPP structure, physico-chemical properties, ice recrystallization inhibition (IRI) and ice nucleation (IN) activity. These insights will translate into the next generation of bioactive iPPs tailored to maximize both IRI and IN. Their impact on heart cell and tissue cryopreservation will be examined to advance our fundamental understanding of freeze injury and dramatically improve post-thaw recovery as well as structural and functional integrity without adverse effects.

Keywords: soft matter,protein polymers,ice nucleation,ice binding,cryopreservation,cardiomyocytes,single molecule localization microscopy,self assembly,biopolymers,antifreeze proteins,single molecule dynamics,ice recrystallization inhibition,thermal hysteresis,protein engineering
Gender, Migration and Illiteracy. Policy and Practice for Social Integration. (GEMILLI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-04-09
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

GEMILLI – Gender, Migration and Illiteracy. Policy and Practice for Social Integration aims to analyse the intersections of gender, migration and illiteracy in contemporary European societies, and to give evidence on policy and practice developments for the social integration of migrant women with low literacy in Europe. Building on the existing literature and research evidence, GEMILLI proposes an intersectional, comprehensive and integrated approach, able to advance knowledge further and to inform social policy in the context of the European Union. Considering the present trends of international migration in Europe and the political and scientific challenges brought by the so-called migration crisis and by the increasing inflows of migrants from countries with high illiteracy, this project proposes a comparative, cross-country and multi-scope analysis of policy and practice between old and new immigration countries, taking Spain and France as case studies. GEMILLI will give evidence on a) the main country-differences regarding the social integration of migrant women with low literacy levels; b) the nature, characteristics and functioning of the local organisations working directly with migrant women with low literacy levels and in charge of training, alphabetisation, language learning, and social integration actions; c) the impacts of the intersections of gender, migration and illiteracy for the life trajectories of women. The research design contemplates both the qualitative and quantitative dimensions of the phenomenon and considers macro (institutional/policy), meso (organisation/practice) and micro (individuals/biographies) levels of analysis. It uses a mix-method methodology, combining complementary research strategies such as policy and institutional analysis, organisational case studies and life stories. The project foresees two short-visits for fieldwork in local organisations in the France and in Spain, and a Secondment in The Council of Europe.

Keywords: women,migration,adult illiteracy,intersectionalities