Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Automation and INtelligence solutions for Automated Road trAnsport systems (AINARA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France,France
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-10-31
Duration (months): 30.0
Total project cost (EUR): 2312320.0
EU funding (EUR): 1618623.0
Participants: 2
Project status: CLOSED

With an expertise of the highest European level in robotics, +10 years of experience in the field of autonomous vehicles and several proofs of concept in operational environment (TRL6/7), RDS (spin off of ROBOSOFT) is the only European company to master all of the software components allowing Autonomous Road Transport Systems to reach the levels of robustness and reliability required for passenger transport. Without waiting for the legal framework, which is being implemented thanks to the efforts of the CityMobil2 project, the market study conducted as part of the TAXISAT project revealed that the 1st wave of user demand would emerge in Europe in 2015 for autonomous transport services in pedestrian city centres and private sites such as industrial or theme parks. These markets will grow even faster that the vehicle manufacturers, Transport Organising Authorities or Operators will be able to adapt their services to future mobility challenges. For this, they will need key skills in robotics, intelligence and fleet management. RDS has the means to satisfy them by providing off-the-shelf ARTS AUTOMATION and INTELLIGENCE solutions. Current solutions are highly customized in an engineering mode and are not compatible with a wider uptake of its technology. To take a solid position on the emerging global autonomous vehicles market and acquire an industrial dimension, RDS is convinced that best strategy is to deliver Commercial Off-the-Shelf software packages, which will offer recurring revenues and promising growth and profitability prospects thanks to software licences sales. The objective for RDS is now to industrialise its software offer, to be fully compliant with the new EU Directive under development and to test the relevance of the associated business model with the ultimate ambition to become a leader in the provision of software solutions for vehicle automation and fleet management, for passengers and goods transportation.

Keywords: autonomous road transport systems,arts automation and intelligence software,software industrialisation,testing and certification,demonstration in real conditions
Confronting sexual pluralism: the regulatory dilemmas and policy challenges of non-monogamous family formations (CONFAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project addresses the question of how the state should deal with radical sexual pluralism, and in particular how it should take up the challenges and difficulties raised for law and public policy in accommodating non-monogamous relationships and family formations. This is a multidisciplinary project drawing on diverse research sources (political philosophy, normative theory, social science data, doctrinal analysis, face-to-face in-depth interviews, and focus groups). It will explore models of non-monogamy – particularly polyamory and polygamy – in the UK to understand how they might pose a both legal and social challenge to traditional family law and regulation. This study thus provides a lens and case-study through which a core question for contemporary public policy is addressed: what legal and public policy instruments could and should the state adopt to deal with sexual and socio-cultural difference? The research will be conducted in four Work Packages (WPs). WP1 will critically assess the available literature on the social character, public relevance and legal status of non-monogamous relationships and family formations vis-à-vis monogamous ones. WP2 will involve in-depth semi-structured interviews with members of polyamorous and polygamous relationships and families to understand how law in its current form is experienced and the problems complex family forms face. WP3 will offer a philosophical-political analysis of the question of if and how the state should devise policy measures for the recognition of polyamorous and polygamous relationships and whether the best strategy is the production of a new relationship-recognition model, defined by specific legal provisions, or, conversely, the recognition of the contractual will of the parties. WP4 will involve members of relevant civil society organisations and state institutions in two focus groups to review the findings and indicate research gaps, potential biases, and areas for further development.

Keywords: pluralism,sexual pluralism,monogamy,family,family law
Low Cost Onshore Power Supply (LoCOPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 3537931.25
EU funding (EUR): 2476551.88
Participants: 1
Project status: CLOSED

PowerCon aims to pursue a major market opportunity by demonstrating and further commercializing a competitive Onshore Power Supply (OPS), to provide electricity for large sea-going vessels when at quayside in port. The OPS system not only reduces the consumption of fuel and the associated air pollution but also eliminates acoustic noise and vibrations from the running engines. The structures behind the unfavourable operational and capital expenses have been hindering the deployment of OPS. Today’s high operational expenses are due to a tax disadvantage on shore side electricity compared with tax-free bunkerfuel available for ships. Because of this, the European Commission in 2007 opened up for exemptions from energy taxes for onshore power and some European countries (e.g. Denmark, Sweden and Germany) can now provide shore side electricity at reduced rate. The high capital expenses are seen as a consequence of the low competition and relatively few capable suppliers on the market causing a high bargaining power of the suppliers. Comparable trends have been seen within the wind power segment in the past where, over time, the total cost of wind turbines has been lowered with great success to compete with fossil fuels. Danish SME PowerCon (PC) have for the last 7 years been part of this success, by adding significant savings into the wind power industry with competitive power solutions. More specifically, we have developed and are successfully commercializing a frequency converter for wind turbines, which is up to 50% cheaper than competing solutions. Now, we aim at bringing the same savings for the maritime sector by introducing a low cost OPS for ships, based on the technology we developed for wind turbines. In LoCOPS Ph 2 project, we aim to demonstrate our technology in operational environment at the Port of Kristiansand,in Norway to prove that our technology will result in a positive business case for ports.

Keywords: competitive onshore power supply,cruise ship ops,high power frequency conversion
The Western European Acheulian Project (WEAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The Western European Acheulean Project (WEAP) aims to characterize the occupational pattern of western Europe during the Middle Pleistocene (MP) –700 to 300Ka–, through the study of Acheulean technology. Recent research has shown that the Atlantic seaboard is the most likely route for colonisation due to the more oceanic climate compared to eastern Europe and to the richer range of resources in coastal areas. Due to cyclical changes in climate with glaciations and interglacials, northern Europe was frequently depopulated and then recolonized through this period probably from source areas in southern France and Iberia. This route-way should therefore bear witness to the cultural links between north and south. From 1 million to 600,000 years ago there is evidence of brief pioneering events in north-west Europe with a small number of sites and small numbers of stone tool artefacts. After 600,000 year ago more sustained occupation is shown by the increase in sites and the much large stone tool assemblages. They also show technological innovation in the form handaxes and possibly in the use of fire, clothing and shelter, which led to the first sustained occupation of northern latitudes. Although there has been much research and new sites excavated over the last twenty years, there has been little integration between the work in Spain, Britain and France. Based on the applicant’s previous experience, WEAP proposes to create a common method of analysis for the study of six Middle Pleistocene sites from UK and France –in agreement with three Middle Pleistocene technologists–, the use of the experimental technology to complete the archaeological record, and the use of new methodological approaches, such as the 3D scanning technology as the most appropriated statistical analysis, to improve understanding of behavioural patterns in order to build models of human dispersals from south-west to north-west Europe.

Keywords: prehistory,lower palaeolithic,western europe,acheulian,handaxe
Partioning Tree Methane Emissions (PaTreME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: CLOSED

The role of plants in the global methane (CH4) cycle remains poorly understood. Plants can emit CH4 from aerobic methane production (AMP), microbial methanogenesis within plants (MMP), and the export soil methane (SM) via plant tissues. These plants-associated CH4 emissions may be quantitatively significant (15-65% of all natural CH4 emissions) but remain poorly constrained. So far, field studies have only quantified the sum of all these plant-atmosphere CH4 fluxes, limiting the degree to which each process can be mathematically described and incorporated into CH4 budgets and models. I am an experienced stable isotope biogeochemist. The MSCA fellowship will allow me to work a world leading group focused on the measurement and modeling of plant-atmosphere trace gas fluxes. Together, we will (a) develop a method to separately quantify AMP, MMP, and SM emissions from plants based on the CH4 isotope values (δ13C, δ2H, and Δ14C) and methanol co-emissions (MeOH:CH4), and (b) apply this method to methane emissions from boreal forest trees at the SMEAR II research site in Southern Finland. Reaching these goals will require (1) adapting stem and shoot enclosure chambers to collect CH4 for offline analysis; (2) identifying characteristic CH4 isotope and MeOH:CH4 values of AMP, MMP, and SM; (3) measuring isotope and MeOH:CH4 values of plant CH4 emissions at SMEAR II, and (4) developing a Bayesian petitioning model for plant CH4 emissions.

Keywords: methane cycle,isotope biogeochemistry,plant methane emissions
Investigating genotype-phenotype correlations in SOX10 neurocristopathies (SOX10mutants)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2018-02-17
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Neural crest formation is a critical event in development, giving rise multiple cell types including melanocytes, neurons and glia. This complex process is governed by a network of transcription factors, such as PAX3 and SOX10 and mutations in these genes have been associated with developmental syndromes. Waardenburg syndrome (WS) and Hirshsprung disease are examples of these neurocristopathies and patients suffer symptoms ranging from sensorineural hearing loss and pigmentation defects to intestinal aganglionosis. Over 50 case studies of WS have been reported in Europe and the incidence is estimated to be 1 in 42 000 people. Recent investigations into the molecular basis of WS have failed to identify genotype-phenotype correlations between gene mutations and symptoms, likely due to the in vitro nature of these studies. It has therefore become clear that new tools are needed to better understand the genotype-phenotype relationship in neurocristopathies in an in vivo context. The SOX10mutants project proposes to address this using a novel zebrafish rescue assay to investigate the effects of SOX10 mutations on the development of cell types deriving from the neural crest. Results from this study would impact significantly on genetic counselling and pre-natal screening of WS patients and provide proof-of-concept data for the use of zebrafish as a tool for studying neurocristopathies. This project is the basis of a multi-disciplinary collaboration between Prof. Robert Kelsh (University of Bath, UK) and Dr Nadège Bondurand (INSERM, France), bringing together zebrafish expertise with WS clinical genetics experience. The research fellow, Dr Deeya Ballim, contributes transcription factor knowledge and a diverse skill set. Deeya aims to establish an independent research group and this fellowship will be a key step in her career development, by expanding her research and academic training, supported by Prof. Kelsh and the University of Bath.

Keywords: zebrafish,novel rescue assay,sox10 transcription factor,waardenburg syndrome,genotype phenotype correlations
Fall in Love wIth Research Tonight (FLIRT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia,Serbia
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-11-30
Duration (months): 19.0
Total project cost (EUR): 181679.0
EU funding (EUR): 144143.0
Participants: 5
Project status: CLOSED

The FLIRT proposes a project that is based on the idea that falling in love with science is just as exciting as falling in love with a real person, and shows how a passionate “crush” can develop into real love. Massive awareness campaign will include continuous coverage and media sponsorship of tens of media outlets, visits to schools, and a development complex interactive RN Community Hub. The RN activities will address to different target groups – the most important being youth aged 13 to 19. It will offer a wide range of indoor and outdoor activities, lasting from early afternoon until midnight, for different age groups, and a variety of personal tastes and interests. All of the activities will, however, evolve around the central point of the event – and that is Love. The project team will undertake a comprehensive impact assessment, aimed at measuring the baseline data indicating the public recognition of research and researchers in Serbia, and the popularity of scientific careers, and then measuring any changes that might occur over the course of the project.

Keywords: science,communication,science communication,public recognition of researchers
Translational regulation in the persistence and drug susceptibility of Mycobacterium tuberculosis (MtbTransReg)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2021-11-30
Duration (months): 78.0
Total project cost (EUR): 1495625.0
EU funding (EUR): 1495625.0
Participants: 1
Project status: CLOSED

Mycobacterium tuberculosis causes human tuberculosis but can also persist for decades as an asymptomatic latent infection. The mechanisms underlying persistence are poorly understood, and the emergence of drug-resistant tuberculosis makes the development of effective new treatments an urgent challenge. Understanding the ability of M. tuberculosis to switch between replicating and non-replicating states during infection and disease is central to the search for improved treatments. The number of copies of a protein produced by a cell is generally viewed as being determined by the number of mRNA transcripts, but recent findings suggest that ‘specialised ribosomes’ can modify proteome profiles by preferential translation of particular mRNA subsets, particularly in response to stress. mRNA molecules contain specific signals that optimise their interaction with ribosomes; known as leader sequences, these include the Shine-Dalgarno (SD) sequence required for canonical translation initiation in bacteria. I recently demonstrated that M. tuberculosis expresses an unexpected number of leaderless mRNA transcripts that lack the SD sequence. In Escherichia coli, only a few leaderless transcripts have been described and they are selectively translated by specialised ribosomes. I propose to test the hypothesis that differential translation of mRNA subsets contributes to M. tuberculosis persistence and drug susceptibility. I will investigate the importance of selective translation of leaderless and SD mRNAs in the context of adaptation to stress and drug resistance in M. tuberculosis, using cutting-edge experimental techniques combined with bioinformatic analyses. The proposed project addresses the fundamental systems biology challenge of establishing quantitative correlations between transcriptome and proteome data, and beyond contributing to the rational design of novel treatments to cure tuberculosis, could help to re-shape classical paradigms of bacterial gene regulation.
Detection of Chromatin Bridges during Cytokinesis (NoCut)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Duplication of the genome and its division into two daughter cells during mitosis is vital for survival of the organism. Cells have multiple mechanisms to ensure that this process is accomplished correctly thereby preserving the integrity of the genome. The final check before cell division is made by the NoCut abscission pathway. In yeast and animal cells, this mechanism monitors completion of chromosome separation, delaying abscission when chromosome bridges spanning the division site are detected. Aurora B is essential for NoCut function, and several of its targets in this pathway have been identified. In budding yeast, NoCut can be triggered by bridges caused by defects in chromosome condensation, decatenation and replication but importantly not by dicentric chromosome bridges. This suggests that structural features of chromatin bridges are essential to generate the NoCut signal. We will investigate the molecular basis of this differential bridge recognition and the signalling pathway acting upstream of Aurora B. We will define the composition of fine and ultra-fine chromatin bridges during cytokinesis in human cells at unprecedented resolution by super-resolution microscopy using dSTORM imaging. In parallel, we will use budding yeast to investigate the role of DNA binding proteins as sensors in the NoCut pathway. We will then establish the significance of these findings in human cells, by assaying the function of putative homologs in NoCut, and their localization in chromatin bridges by dSTORM. By combining approaches in two model systems we will define both the molecular and physical constrains for NoCut activation upstream of the established components of the NoCut pathway. Chromosome instability is associated with many human tumours and in some cases with advanced disease making the detailed characterization of this pathway relevant in our understanding of both basic cellular processes and human disease.

Keywords: cytokinesis,chromosome segregation