Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SoBigData RI Preparatory Phase Project (SoBigData RI PPP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,United Kingdom,Greece,Belgium,Austria,Spain,Bulgaria,Sweden,Netherlands,Poland,Germany,Estonia,Finland,France
Call: Preparatory phase of new ESFRI research infrastructure projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3222266.25
EU funding (EUR): 3222266.0
Participants: 32
Project status: SIGNED

SoBigData RI, with its tools and services, empowers researchers and innovators through a platform for the design and execution of large-scale data science and social mining experiments, open to users with diverse backgrounds, accessible on cloud (aligned with EOSC guidelines), and also exploiting supercomputing facilities. SoBigData RI will render social mining experiments more efficiently designed, adjusted, and repeatable by non-data scientists' domain experts by pushing the FAIR (Findable, Accessible, Interoperable) and FACT (Fair, Accountable, Confidential and Transparent) principles. SoBigData RI will orient resources from multiple perspectives: e-infrastructures and online services developers; big data analytics and AI; complex systems focussed on modelling social phenomena; ELSEC (Ethical, Legal, SocioEconomic and Cultural) aspects of data protection (as defined by the HLEG-AI); privacy-preserving techniques. SoBigData RI PPP will move our RI forward from the simple awareness of ethical and legal challenges in social mining to the development of concrete tools that operationalize ethics with value-sensitive design, incorporating values and norms for privacy protection, fairness, transparency, and pluralism.

Keywords: research infrastructure,esfri,social mining,big data,artificial intelligence,data science
Intermediation and Trust in the Regulatory State: More Regulation, Less Trust? (RegTrust)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel,Belgium,Switzerland,Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2499625.0
EU funding (EUR): 2499625.0
Participants: 4
Project status: SIGNED

Regulation is sometimes a manifestation of distrust, but on other times it is a manifestation of trust. When do trust and regulation compete, substitute for and mutually-support each other? How can we maximize the benefits of both? Is the proliferation of rules around us a manifestation of growing distrust or trust? Is the regulatory state necessarily a low-trust state? To answer these questions, RegTrust introduces intermediation as a governance mechanism and intermediaries as third parties in trust and regulatory interactions. Intermediaries certify products, report compliance, rank organizations, label products, monitor performance, screen behavior, whistle-blow misbehavior, and audit organizations. The regulation literature treats them as regulatory actors; the trust literature, as trustees. Yet intermediaries are both trustees and regulatees, both subjects and objects of trust and regulation. Most importantly, they may determine successes and failures, winners and losers, of trust and regulation. At their best, intermediaries reinforce regulation and trust, and promote polycentric (pluralist) structures of governance. At their worst, they undermine trust in regulation, leading to vicious cycles of failure and re/centralization (monocentric governance). RegTrust examines under which conditions, why, how, and to what effects trust and regulation compete, substitute for, or mutually-support each other. We problematize the role of intermediaries, develop a three-actor (triadic) model of governance, and assess its institutional macro-political consequences. Going beyond the state of the art, this project sheds light on the multiple interactions of trust and regulation in policy and politics. It advances the theory of intermediation; advances the interaction of trust and regulation as a central element of the governance literature; And explores the conditions that may make a regulatory state into a high-trust state.

Keywords: regulation,trust,governance,intermediaries
A new generation of injectable implants based on Cell-Assembled extracellular Matrix (CAM) (CAMFLAKES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-07-01
End date: 2027-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Injectable implants are widely used to treat numerous medical conditions, such as stress urinary incontinence, which affects 1 in 5 women. They also represent a large fraction of aesthetic procedures (e.g., wrinkle correction). The efficacy of current products is hampered by the fact that they create a chronic inflammatory response called the Foreign Body Reaction (FBR). As a result, implants have limited durability, requiring repeated procedures, and are associated with complications such as chronic pain and tissue erosion. We propose a new paradigm that avoids the FBR by providing a tissue-engineered injectable implant that is completely biological and human. This non-living product will support the creation of an actual living tissue that will be long-lasting without chronic inflammation. Our strategy is based on a unique material described in the project. The potential of this implants will be demonstrated through two work packages described in the project. Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4 work packages. These outcomes will justify optimizing production methods, expanding in vivo analysis, and will support a commercial endeavor targeting multiple clinical applications.
KARST: Predicting flow and transport in complex Karst systems (KARST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,France,Slovenia,Switzerland,Canada
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 9884611.25
EU funding (EUR): 9884611.0
Participants: 6
Project status: SIGNED

Karst aquifers are a treasure and a threat: while up to 25% of the world population depends on them for drinking water, they also have capabilities for extremely fast conduction of water and contaminants. In the light of climate change, we need to prepare for extreme flooding and understand the consequences for karst aquifers. Despite their socio-economic importance, decades of research, and high-profile disasters, karst structures and processes remain notoriously difficult to assess. Because of the complexity of karst and its lack of accessibility, the foundations of flow and transport modeling in karst systems are weak. Key phenomena related to extreme events such as flash floods and heavy tails in tracer recovery are still beyond current modeling capabilities. KARST will establish the next generation of coupled stochastic modeling frameworks to predict karst processes, assess the vulnerability of karst aquifers, and forecast their response to extreme events. Our approach will bridge structures and processes on all scales, far beyond the capabilities of current theories and computer simulations. This will be achieved by targeting three key objec- tives: (i) Identification and quantification of flow and transport dynamics at the conduit scale. (ii) Characterization and modeling of karst network structure at the catchment scale. (iii) Derivation of a new upscaled approach to predict karst processes at different resolution scales. Together, this will result in an unprecedented multiscale modeling framework for the prediction of flow and transport in karst. Solving this long-standing problem is possible thanks to the synergy of the KARST PI team combining the set of skills and knowledge (hydrogeology, physics, mathematics) required to make a ground-breaking step in this field. Beyond that, the new approach is expected to impact other real-world systems in medicine (capillary networks), neuroscience (brain microcirculation) or glaciology (meltwater flow in glaciers).

Keywords: karst,networks,upscaling,flow,transport,graphs,structure,anomalous transport,continuous time random walks,lagrangian analysis,particle methods,dispersion,turbulent transport,groundwater,contamination,floods
Implicit Learning in Addiction (ILiAd)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-06-30
Duration (months): 29.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Alcohol Use Disorders (AUD) affect more than 11 million people in Europe (~3.4% of the population). Basic research in the field is conducted in animal models, using conditioning tasks, and then translated to humans. However, this translation is limited by multiple factors, and one reason is that animal research uses objective behavioral and physiological measures, which is very different from human research based on conscious subjective reports (i.e., craving). A solution to this disconnect is to study human conditioned responses implicitly, without participants’ conscious cognitive control. In my previous research, I have developed novel procedures to measure implicit Pavlovian conditioning. Through 3 experiments I will use these techniques to study implicit reward and aversive sensitivity across the alcohol use spectrum. The first objective is to study the implicit processes characterizing hazardous drinkers and students diagnosed with AUD (WP1). The second objective is to better understand the neural and behavioral correlates of implicit learning (WP2). As part of this multidisciplinary project, I will develop my skills as a scientist; I will learn new experimental techniques (i.e., EEG) and obtain experience in longitudinal research. I will also gain leadership and management skills as an independent researcher. Prof. Wiers, the supervisor of this project, is a leading expert in addiction and implicit processing. Under his mentorship, I will increase my knowledge about addiction research and create academic relationships with his network of collaborators. The findings and publications generated through this project can significantly impact the addiction field, increasing theoretical understanding of AUD and providing us with novel clinical and diagnostic tools with large societal and clinical impact. I will use this project as foundation to gain the skills and experiences necessary to in the future lead my own laboratory on cognitive psychology and addiction.

Keywords: addiction,alcohol use disorder,implicit learning,consciousness
Road to Friday of Science and Art (ReFocuS Art)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Serbia
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-01
End date: 2023-12-31
Duration (months): 20.0
Total project cost (EUR): 267050.0
EU funding (EUR): 267050.0
Participants: 4
Project status: CLOSED

ReFocuS Art (Road to Friday of Science and Art) project aims to substantially raise public awareness about the importance and positive role of science for and in society by bringing the researchers into the focus of the general public. The 2020 year demonstrated the necessity for the state of the art of science in everyday life and large creativity in the research process to respond to contemporary challenges. Skills, such as creativity, problem-solving and critical thinking will be fundamental for the carriers of today's generations. We argue the same skills are crucial for the researcher career, and instrumental in art as well. Science and art may have different subjects and different audiences but share the investigative spirit, motivation and skills. Both artists and researchers strive to see the world in new ways, and when they succeed in those endeavours, the general public acquires a novel perspective and new knowledge. Both are based on the process which can lead to encouraging to use creativity and critical thinking, and questioning the world around us. This year, by using Science is art as an overall theme, we want to promote the creativity, critical thinking and problem-solving skills of researchers and artists as an imperative for the development of science and society. In this way, we want to inspire and stimulate young people to be innovative and to seek creative solutions to different problems and challenges. The activities will take place in the 14 cities and 46 diverse venues through Serbia, including research institutes, old streets and houses, museums, archaeological sites, fortress, science clubs, shopping malls, city parks and libraries. Some of the activities will be exclusively online, allowing reaching the public outside proposed cities. The diversity of partners in the project, both cultural and scientific institutions, will expand the general image of how and why science and researchers are important for society.

Keywords: skills,creativity,critical thinking,problem solving,science,art
Multi-kingdom biodiversity in residential environments and immune-mediated diseases in children (Residents)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1730426.0
EU funding (EUR): 1730426.0
Participants: 1
Project status: SIGNED

All organisms constantly shed traces of their DNA in the environment. Scientists can collect this DNA and explore who is or was there, across kingdoms of life. Our immune system is also aware of organisms in the environment as it screens everything it faces. During the first months of life, the immune system adapts to its current environment. Limited exposure to bacteria or fungi during this sensitive developmental period can lead to misdirected immune responses and development of immune-mediated diseases such as asthma. Yet, the health-impacts of other organisms have not been addressed. The major reason is a lack of data and methods to quantify total biodiversity exposure. In Residents, I will quantify human exposure to multi-kingdom biodiversity, i.e., to organisms from all six kingdoms of life, and link it to immune function development during the first year of life. I study if the potential linkage can affect the later risk of immune-mediated diseases. I bring together recently matured DNA-based biodiversity monitoring, longitudinal immune profiling, and register-based diagnoses of immune-mediated diseases. I hypothesize that multi-kingdom biodiversity exposure benefits immune system development and health. Therefore, ongoing biodiversity loss can seriously hamper human health. I study associations between biodiversity loss and children’s immune-mediated diseases at unprecedented spatial and temporal resolutions encompassing a whole nation and four decades of unique biodiversity and registered health data. My transdisciplinary project brings together ecological and immunological research. It takes a leap in the resolution at which biodiversity potentially affecting our health is quantified in our residential environments. This multi-kingdom biodiversity monitoring can open a new frontier in health research due to possibility to study both positive and negative health impacts of various organisms.

Keywords: targeted metabarcoding asthma and atopic diseases proteomics epidemiology ecoimmunology biodiversity hypothesis hygiene hypothesis
UnderstandiNg fraIlty tOwards a future of healthy ageiNg (UNION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,Germany,United States,Belgium,United Kingdom,Sweden,Austria
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 3534427.54
EU funding (EUR): 3423240.0
Participants: 23
Project status: SIGNED

With falling birth rates and increasing life expectancy we are an ageing society. 20% of boys and 25% of girls born in 2019 are expected to reach their 100th birthday. This would be good news if it were not for the fact that healthy life span has not kept pace with increasing longevity and now on average adults spend the last 15-20 years of life in ill health. Frailty is a major component of ill health in old age and refers to an enhanced vulnerability to stressors, such as falls, surgery or infections, which was demonstrated clearly in the mortality data for the COVID19 pandemic. The transition from robust health to frailty is a critical factor in the loss of independence and places increased pressure on health and social care. All of this has led governments to prioritise the enhancement of healthspan. The Doctorate Network on UnderstandiNg fraIlty tOwards a future of healthy ageiNg (UNION) is a multi-partner joint doctoral research training network with the overall aims of educating 13 Early Stage Researchers (DCs), advancing the current understanding of frailty, and providing innovative solutions on how healthy ageing can be achieved. UNION brings together world leaders in a range of relevant disciplines (frailty, ageing biology and ageing medicine, inflammation, immunosenescence, immunometabolism, stem cell biology) with state-of-the art technologies including mass spectrometry metabolomics, advanced imaging, artificial intelligence, CRISPR-CAS9 libraries, SPECTRA 35-colour flow cytometry, global and conditional knockout mice. This technological excellence is applied to the clinical situation through unique longitudinal human ageing and frailty cohorts, longitudinal assessment of age-related multimorbidity in animal models and innovative multidimensional frailty indices in humans. Together this integrated activity will provide the highest quality training and research environment in our rapidly ageing society.

Keywords: frailty,immune senescence,sarcopenia,epidemiology,interventions,computational science
Improving cereal yield predictions under drought: root diameter as a predictor of plant water uptake across scales. (DROOGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1996749.0
EU funding (EUR): 1996749.0
Participants: 1
Project status: SIGNED

As droughts are becoming more frequent and severe, there is a call for adaptation strategies that enhance the crop’s resilience to these climate conditions. One pathway to do so is to select crops whose root system optimize the soil water uptake. However, the identification of adequate ideotypes is compromised by the limited understanding of the structural drivers controlling the water uptake from the root to crop scales. This knowledge gap is attributable to the multiscale and nonlinear nature of the soil-plant interactions. DROOGHT aims to address these gaps by identifying the dominant drivers of the complex below-ground processes in cereal crops. Based on suggestive pieces of evidence, the project builds on the primary hypothesis that the distribution of the root diameter within a cereal root system is an indicator of its structure and functions at the organ and field scales. The value and groundbreaking nature of such an indicator would lie in its simplicity: diameters are one of the easiest root traits to measure in any field set-up and at large scales. I will test this hypothesis and identify the dominant structural root traits controlling plant water uptake dynamics under water-limited conditions using complementary in silico and in vivo approaches. The outputs of this project will be (i) a novel multiscale computational framework that links local root structures to plant and crop functions; (ii) a phenotyping pipeline that links root structure to function; and (iii) the identification of cereal root properties favorable to higher yields across European pedoclimatic conditions and climate change scenarios. More broadly, this project will allow a significant step forward in our understanding of the role of root systems' structural traits on water uptake dynamics. It will provide practical insight for breeders and simpler, more elegant below-ground processes model components to insert into crop models.

Keywords: root,drought,diameter,model,phenotyping,wheat