Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Visualizing liver immunopathology progression during hepatitis B infection by liver Intravital Microscopy (IVM) (LIVER IVM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-06
End date: 2015-05-05
Duration (months): 24.0
Total project cost (EUR): 179739.6
EU funding (EUR): 179739.6
Participants: 1
Project status: CLOSED

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infect the liver, and are unique in their capacity to cause persistent infection, cirrhosis, and liver cancer. The lack of experimental approaches to study these infections, due to the limited host range to humans and chimpanzees, have hampered the understanding of fundamental issues regarding their pathogenesis. It is now clear that both infections are very similar, HBV and HCV are non-cytopathic viruses that replicate exclusively in the hepatocytes, thus most of the clinical syndromes are associated to a virus-specific CD8 T cell-mediated immunopathology that fails to clear HBV or HCV infection, creating a chronic necroinflammatory process which results in hepatic fibrosis/cirrhosis and hepatocellular carcinoma (HCC). While some of the rules governing CD8 T cell behavior in the liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8 T cell migration and interaction with other cell types at the single-cell level. For instance,it has been previously shown that the intrahepatic recruitment of virus- specific CTLs is platelet-dependent, and in vitro experiments suggest that specific effector CD8 T cells tightly interact with activated platelets. Advances in the field of live imaging allow us for the first time to answer these questions directly in the living animal, by visualizing liver immunopathology as it progresses in vivo. To this end, the recently developed intravital microscopy (IVM) model in the liver of anesthetized mice, allows to generate time-lapse movies to dissect the interactive behavior of intrahepatic CD8 T cells,to elucidate the cellular and molecular mechanisms by which effector CD8 T cells migrate to the liver,recognizing hepatic antigens in vivo within the normal or fibrotic liver, and how this affects the T-cell mediated immunopathology that finally leads to fibrosis and hepatocellular carcinoma.

Keywords: l406 cancer and its biological basis,l602 adaptive immunity,l608 virology,l213 systems biology,l301 morphology and functional imaging of cells,l611 prevention and treatment of inf
Modeling and Integration of Orchestrated Classrooms through Tangible and paper Interfaces (MIOCTI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Despite the considerable investment on Information and Communication Technology (ICT) infrastructures at local, European and worldwide levels, much of the technology available in our schools and universities remains under-utilized. Although insufficient technical training is often posed as an excuse for such underuse, ICT’s current lack of integration with the rest of the classroom processes (e.g. learning activities using pen and paper, homework, etc) and the inefficiencies that such lack introduces, are a more likely culprit. Thus, these supposedly ICT-enhanced classrooms are currently hard to manage (i.e. to orchestrate) productively, given the current divide between digital media and other analog technologies present in the classroom ecosystem, such as pen and paper. In the current proposal, the prospective fellow will jointly work with the CRAFT group at EPFL (Lausanne, Switzerland), combining bottom-up observation of classroom workflows with top-down theorizing (e.g. based on Shannon’s Information Theory) to produce more complete models of classroom orchestration. Moreover, classroom orchestration itself will be enhanced by the application of tangible and paper user interfaces (through objects already present in most classrooms), and the leveraging of augmented reality (AR) techniques (now available even on inexpensive hardware). The combination of these theoretical and technological contributions will help produce a more efficient classroom, which is at the same time natural to both teachers and students. This proposal not only will help the researcher to attain a more complete set of research and complementary skills (including contacts with startups in the educational technology industry). Also, this project has the potential to increase the impact of ICTs in everyday formal education, a competitive advantage that Europe cannot afford to lose.

Keywords: g105 human computer interaction and interface,s213 education,technology-enhanced learning,classroom orchestration,tangible user interfaces,paper computing
The Winner-Loser Divide?: A Comparative Analysis of Voting Behaviour and Cleavage Formation in Post-Communist Party Systems (WINLOSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The proposed project consists in a comparative analysis of the impact of the ‘transition winner/loser’ divide on political cleavages in four post-communist party systems: Poland, the Czech Republic, Slovakia and Hungary. It has two key purposes: (i) to identify whether winner/loser cleavages emerged in these countries over the first two decades of transition, and (ii) to explain these outcomes in comparative perspective. From the beginning of the post-communist transition, the notion of ‘winners’ and ‘losers’ was commonplace. Observers expected that the new inequalities introduced by the logic of the market society and the differentiated adjustment of social groups would deepen and crystallise social hierarchies, to the benefit of those individuals who possessed the capital to take advantage of new opportunities and the detriment of those who lacked such capital. Many also predicted that the winner/loser divide would form the basis of political divides in the emergent party systems, and that these divides would subsequently harden into lasting political cleavages. Although the winner/loser divide has been employed in a number of country studies, the literature on this topic is lacking in three respects: (i) no studies use a comprehensive theoretical approach that treats the divide as both objective and subjective in nature; (ii) there are currently no comparative, diachronic studies focusing directly on this cleavage that cover the whole of the transition period, and (iii) few studies to date have analysed the regional, aggregate-level dimension of this divide using appropriate methods. The proposed project will fill this research gap. Such research is particularly relevant at present in light of the potentially profound impact of the European economic crisis on the nature of party politics in the region, since the generation of new cohorts of ‘losers’ is likely to have significant implications for the development of the still-nascent party systems of the region.

Keywords: cleavages,central europe,voting behaviour,regional differences,ecological analysis
Dazzle markings and movement as an anti-predator strategy (MOTDAZZ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-11-04
End date: 2015-11-03
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Predation exerts strong selective pressures that have far-reaching effects on prey. As a result, many animals that are vulnerable to predation have evolved colouration or markings to evade capture. Some markings may prevent predators from accurately judging the speed or trajectory of moving prey, decreasing the likelihood of successful capture. Motion dazzle markings are high contrast patterns that may function in this way. The aim of this project is to determine what factors are important in motion dazzle and to test the efficacy of motion dazzle markings using an ecologically relevant predator. The first part of the project will identify what factors are important in motion dazzle using humans as predators. Participants will interact with touch screens and ‘catch’ prey that differ in their shape and colour, to determine whether these factors alter perception of speed or trajectory. The second part of the project will quantify the efficacy of motion dazzle markings using scrub-jays as predators. By using touch screens to test the capture rate of targets that vary in their markings, shape, colour and speed, this project will use a realistic predation scenario to identify whether these factors are important in evading capture. By combining sensory ecology, physiology and cognitive research, this project will test for the first time whether motion dazzle markings can affect prey capture rate, and will determine how perception is altered. Very few studies have investigated the role of anti-predator markings when in motion, and given that the majority of predator-prey interactions occur when prey are moving, this research aims to address an important knowledge gap. The project will identify whether certain markings are more effective than others, and will determine how animals have evolved to protect themselves from attack when moving.

Keywords: l504 sensory systems,l507 cognition,l806 animal behaviour,l801 ecology,l402 comparative physiology
MHD modeling of wind tori and particle acceleration in pulsar wind nebulae (PWNTORI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2014-08-31
Duration (months): 12.0
Total project cost (EUR): 124621.4
EU funding (EUR): 124621.4
Participants: 1
Project status: CLOSED

The proposed research aims to constrain the energy spectrum of accelerated particles in pulsar wind nebulae (PWNe), and their contribution to the recently measured primary cosmic-ray positron spectrum. To this end, observations of synchrotron emission from the inner wind tori of young PWNe, in particular in the infrared domain, will be modeled using relativistic magnetohydrodynamic (MHD) numerical simulations developed at the host institute (Arcetri). The radiative and adiabatic energy losses of the accelerated electrons and positrons prior to their escape into the interstellar medium will be computed using relativistic MHD simulations of PWNe in their later, bow-shock phase, when they are most likely to contribute to the leptonic cosmic ray spectrum. The combination of these two parts of the project will allow more precise predictions of the contribution of PWNe to the primary cosmic-ray positron spectrum, and help quantify the potential necessity for additional, alternative sources of positrons such as the annihilation of dark matter particles. The proposed mobility will give Dr. Gallant the opportunity to reach higher levels and a greater balance of theoretical and observational expertise, through collaboration in state-of-the-art theoretical research, as well as interaction with experts in infrared observation, at Arcetri. The skills acquired, and the longer-term collaborations at the European level which his mobility will foster, will allow Dr. Gallant to continue to play a leading role in the scientific exploitation of future high-energy astrophysical experiments, and in particular the planned ground-based gamma-ray observatory CTA, in which European groups are deeply invested.

Keywords: phy: astronomy,astrophysics and cosmology,acceleration of particles,pulsar wind nebulae,relativistic magnetohydrodynamics (mhd),cosmic rays,synchrotron radiation,infrared,polarisation,x-rays
multimode FIber Radio technology for cost-efficient indoor Mm-WAve REmote antenna systems (FIRMWARE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

FIRMWARE aims to develop technologies and systems to exploit unused capacity in multimode optical fiber to transport ultra-broadband 60GHz wireless signals for indoor networks. The project investigates the low cost, energy efficient and flexible deployment of such networks, using predominantly installed worldwide graded index multimode fiber (GI-MMF), as the indoor optical medium, and integrated novel photonic array antennas, as adaptive transceivers. Based on an innovative methodology of theory and experiments, we aim to achieve 3Gb/s wireless coverage over 10m utilizing GI-MMF transmission at 1550nm, with the aid of a single mode fiber (SMF) to GI-MMF coupling scheme, for short area, indoor, optical lengths of the order of 100m or more. The main challenge of this work is to develop technologies and techniques that over come bandwidth limitations inherent in the multi-mode optical medium while still delivering signals that are appropriate for wireless transmission. To achieve this, concepts including photonic-up conversion and wavelength re-use techniques will be explored, and orthogonal frequency division multiplexing (OFDM), will be deployed to provide the necessary tolerance to the optical/wireless dispersive channels. Finally, a cost-effective hybrid FTTx/60GHz wireless transmission scheme will be exploited based on a SMF/ indoor GI-MMF topology in order to provide adaptable coverage for future converged wired/wireless scenarios.

Keywords: optical communications,radio over fiber technology,60ghz communications
Avant Garde Approaches to Processable multiscale conjugated polymer hybrid materials with enhanced Electronic properties and water-repellency (AGAPE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-12-01
End date: 2015-11-30
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

This project aims to circumvent the most severe flaws of Conjugated Polymers (CPs hereafter), namely their processability and stability, while not compromising or even improving their electronic performance. Approaches are presented that will produce performing, water-repellent and processable CPs to feed the emergent Hydrophobic Electronics. A procedure will be developed to allow the CPs grafting on OH-containing nanoparticles profiting of the applicant’s knowledge on NHC catalysts, acquired along his 2-year stage at Prof. Navarro’s Laboratory in the USA. Nanoparticles are selected to fulfill the double purpose of i) making the solution/suspensions of CPs thixotropic, thus easing processability, and ii) making the final material’s surface rough and so water-repellent. These hybrids will be incorporated into a third component (a polymer, solvent or CPs solution) to produce multiscale water repellent CPs, by taking advantage of the Host Group on surface modification, polymer compounding and superhydrophobicity. This project lies at the interfaces of Polymer Chemistry, Catalysis and Surface Chemistry on one hand, and requires the joint collaboration of Engineering, Chemical Physics and Pure Organic Chemistry. The rare combination of the Applicant’s and Host Group’s expertise allows to reasonably expecting the successful design of novel materials with exciting new properties

Keywords: c112 catalysis,c119 structural properties of materials,c126 new materials,c121 surface modification,c139 polymer chemistry,c138 macromolecular chemistry,c101 physical chemistry
Exploring the phenotypic landscape of nectar yeasts in relation to their genetic background (PHENOGENYEAST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

Nectar inhabiting yeasts are increasingly considered as important third players in plant-pollinator mutualisms. Although it was generally assumed that nectar properties represent intrinsic plant features that are stable in time, it has recently been shown that nectar yeasts, may change nectar chemistry and attractiveness, and consequently pollination success and plant fitness. However, underlying mechanisms how yeasts affect pollinator behaviour and reproductive success are still poorly understood. In order to better understand the role of nectar-inhabiting yeasts in plant-pollinator interactions, physiological characterization of nectar yeasts should be pursued. In a preliminar small-scale study, high phenotypic diversity was observed between different yeast strains from nectar belonging to the same species, according to the origin of the isolates. The major aim of this project is to study the interspecific and intraspecific phenotypic diversity in nectar-dwelling yeast species in relation to their origin, nectar features and their genetic background using a huge collection of over 2000 yeast strains. Focus in the project will be on yeast species that predominate nectar yeast communities along a disparate group of plant species, namely Metschnikowia gruessii and M. reukauffii. We expect that our results will contribute to a better understanding of the phenotypic landscape of nectar yeasts and their impact on pollinator attraction. In addition, we expect that our results on the genetic basis of the phenotypic variation in terms of yeast origin will provide support to the ‘diversifying selection hypothesis’ maintaining high local genotypic diversity in clonal lineages. At the same time, such exploration would help us to unravel the evolutionary mechanisms enabling high phenotypic diversity as presumed in nectar yeast species.

Keywords: v304 conservation biology - ecology - genetics,v305 ecology,yeasts,nectar,pollination biology,phenotypic variation,diversifying selection,genotypic diversity
PERSONAlised Health Monitoring System (PERSONA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-05-05
End date: 2017-07-24
Duration (months): 36.0
Total project cost (EUR): 294693.0
EU funding (EUR): 294693.0
Participants: 1
Project status: CLOSED

Depression is one of the most prevalent health problems in Europe. The current standard for depression diagnosis is still based on subjective clinical rating scales derived from methods that were developed in the early 1960s. In this project, the candidate will exploit the potential of depression monitoring from the continuous measurement of physiological, behavioral and vocal characteristics of an individual. He will research algorithms based on the combination of aforementioned metrics which enable accurate and objective diagnosis. The fellow will implement these algorithms on a lightweight mental health monitoring platform based on a smartphone and body sensor network which can be used during daily life activities. He will use novel methods of Affective Computing thus maintaining and enhancing the candidate’s position at the forefront of advances in this field. This project will provide a new platform that helps to expand mental healthcare into the homecare domain where existing treatment methodologies have not yet demonstrated substantial effectiveness as compared to in-ward settings. Also the ability of long-term monitoring of mental health has the potential to help in the pre-clinical assessment, early diagnosis, and treatment prediction of other than depression severe disorders like bipolar disorder, where a patient exhibits extreme swings in mood related to manic and depressive episodes. This fellowship will facilitate the transfer of the fellow back to academia from an industry-based research environment. The skills acquired during the fellowship and the experience and knowledge gained in industrial research labs would allow the fellow to apply for the tenure position in a European university which is an ultimate goal of his career.

Keywords: multisensory technology,multisensing,biomedical engineering,wireless systems