Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative nanoparticle formulation for a miR-133 based treatment of cardiac hypertrophy (miRCaP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Innovative nanoparticle formulation for a miR-133 based treatment of cardiac hypertrophy Cardiovascular diseases (CDs) are growing problems worldwide, affecting as much as 1% of the population. The causes include ischemic, toxic, genetic, post-inflammatory and structural defects; often multiple etiologies are present within an individual patient germane to the contraction failing, resulting in a mortality of ca. 50% within 5 years from diagnosis. Unexpected roles have been unveiled for microRNAs, important key-players in such pathogenesis, able to regulate levels of genes that govern cell remodeling. In line with this, development of microRNA-based drugs aimed at preventing stress-induced dysregulations of microRNA levels has attracted remarkable attention as potential candidates for therapeutic applications. Particular attention is paid to the miR-133, a muscle-specific microRNA, which has been found inversely related to pathological cardiac hypertrophy. However, a key challenge of microRNA-based drugs relies on delivery efficiency, toxicity and specificity. Here, we propose to generate innovative and effective therapeutic strategies based on the development of novel biocompatible and bioresorbable calcium phosphate nanoparticles (CaP-NP) for carrying miR-133 selectively to the heart. Our aim is to functionalize CaP-NPs for a selective delivery of the therapeutic miR133 to the pathological heart. The development of a novel approach based on CaP-NPs might be an efficient cardiac drug-delivery system for a specific release of miR-133. The successful outcome of this proposal will provide a relevant preclinical proof-of-concept necessary for 1) the development of additional Intellectual Properties, 2) the translation into a commercial strategy and business case, and 3) the identification of strategic partners and venture capitalist.

Keywords: microrna,nanotherapy,cardiovascular diseases,cardiac hypertrophy
Multiplex qPCR detection and chemical analysis towards multifunctional diagnosis (MULTIDET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-15
End date: 2018-09-14
Duration (months): 12.0
Total project cost (EUR): 87500.0
EU funding (EUR): 87500.0
Participants: 1
Project status: CLOSED

Kidney Disease in England costs more than breast, lung, colon and skin cancer combined. In particular, chronic kidney disease (CDK) affects 10% of the population worldwide. This is bound to increase as our population ages and, if CKD is not detected early enough, the patient may progress to kidney failure which requires therapies (dialysis or transplantation) that are extremely costly and weighs heavily on healthcare budgets. Even though several cheap traditional tests already exist based on a diagnosis of urinal or blood samples, there is no technology available to measure both key RNA biomarkers of kidney diseases and perform traditional chemical analysis. The development of fast multiplex quantitative PCR (qPCR) technologies offers a unique opportunity to propose a Point of Care Test (PoCT) able to perform new multifunctional cheap diagnostics. By hiring an Innovation Associate with an expertise in microbiology and chemistry, ELVESYS wants to develop the first multifunctional, fast and affordable PoCT device for kidney disease diagnostics. This system will enable any practitioner to propose a diagnosis based on the simultaneous analysis of urinal and blood samples in a single test during the time of a visit to the doctor’s office. The Innovation Associate will benefit from ELVESYS expertise in the world fastest multiplex qPCR system to develop this first prototype. The MULTIDET project is relevant to bring a PoCT system to the market within the next couple of years. This system will bring ELVESYS to a pioneering position for multifunctional PoCT systems to solve medical and social issues of kidney diseases that weigh severely on the EU healthcare systems. This project will also allow ELVESYS to train an Innovation Associate in entrepreneurship so that they can later become part of the team or start their own spin-off company to commercialize the PoCT system developed.

Keywords: kidney disease,diagnosis and monitoring,ultrafast multiplex rt qpcr,urinal analysis,device,point of care test,kidney disease biomarkers
Next-generation equipment tools and mission-critical strategies for First Responders (RESPOND-A)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Italy,Italy,Cyprus,Bulgaria,Greece,Greece,Bulgaria,Greece,Belgium,Greece,Sweden,France,Netherlands,Netherlands,Montenegro,Portugal,United Kingdom,United Kingdom
Call: Technologies for first responders (H2020-SU-SEC-2019, 2019)
Start date: 2020-06-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 7666225.3
EU funding (EUR): 7666225.0
Participants: 35
Project status: SIGNED

With the evolving threat of climate change and the consequences of industrial accidents to becoming more severe, there is an increasing need for First Responders to access reliable and agile information management systems that offer as higher Situational Awareness and better Common Operational Picture. To match with current trends, the RESPOND-A project aims at developing holistic and easy-to-use solutions for First Responders by bringing together the complementary strengths of its Investigators in 5G wireless communications, Augmented and Virtual Reality, autonomous robot and unmanned aerial vehicle coordination, intelligent wearable sensors and smart monitoring, geovisual analytics and immersive geospatial data analysis, passive and active localisation and tracking, and interactive multi-view 360o video streaming. The synergy of such cutting-edge technological advancements is likely to provide high-end and continuous flows of data, voice and video information to First Responders and their Command & Control Centres for predicting and assessing the various incidents readily and reliably, and saving lives more efficiently and effectively, while maximising the safeguarding of themselves, before, during and after disasters. To this end, RESPOND-A envisions at exercising First Responders for getting familiar with the project technological outcomes, and demonstrating their real-world performance and effectiveness in the classified training facilities of our Responder Partners under hydrometeorological, geophysical and technological disaster scenarios.

Keywords: common operational picture,mission critical,first responders,situational awareness,natural and man made hazards
Participatory Urban Governance between Democracy and Clientelism: Brokers and (In)formal Politics (BROKERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2022-01-31
Duration (months): 66.0
Total project cost (EUR): 1497570.0
EU funding (EUR): 1497570.0
Participants: 1
Project status: CLOSED

The emergence of participatory governance has resulted in the delegation of governmental responsibilities to citizens. Individuals position themselves as voluntary mediators, or brokers, between the government and their fellow citizens. This research asks: what are the roles of such brokers in participatory urban governance, and how do they influence democratic governance? This study will investigate ethnographically how brokers position themselves in administrative schemes, and examine the formal and informal dimensions of their performance. It will analyse the practices, discourses and networks, both in and out of officially sanctioned channels and government institutions. The research approaches brokers as ‘assemblers’, connective agents who actively bring together different governmental and citizen actors, institutions and resources. The scholarly debate on brokerage within participatory governance is divided into two different arguments: first, an argument about neoliberal deregulation located in the Global North, which encourages the practices of active citizen-mediators, and second, a modernization argument in the Global South, which sees brokers as remnants of a clientelist political system. This research will combine these arguments to study settings in both the North and the South. It employs a comparative urbanism design to study four cities that are recognized as pioneers in democratic participatory governance, two in the North and two in the South: Rotterdam (NL), Manchester (UK), Cochabamba (Bolivia) and Recife (Brazil). This research builds upon theories from political anthropology, urban studies, citizenship studies and public administration to develop a new framework for analysing brokerage in participatory urban governance. Understanding how the formal and informal dimensions of participatory governance are entwined will contribute to our ability to theorize the conditions under which this type of governance can give rise to more democratic cities.

Keywords: anthropology of the state,brokerage,brazil,informal politics,informality
Individualised COgnitive and Motor learning for the Elderly (ICOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2023-01-28
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

This project aims to create a method with high efficacy aimed at providing an individualised approach to motor sequence learning in elder adults. The current problem is that the provision of motor learning programs have little/no consideration of individual cognitive and motor differences, and therefore varying levels of improvements. The innovation is to provide a management solution to the ageing demographics across Europe by creating an evidence-based approach targeting cognitive and motor learning parameters for elder adults to improve their overall motor function using an ecological dancelike sequence learning task. We propose a three-stage approach to investigate and provide a viable solution. In the first stage, we will address historical and current theoretical issues with the quantification of motor learning development in elder adults. Addressing topics such as dynamical systems and the aggregation of performance analyses in the face of a large range of baseline physical differences in the elderly will shed new light in a theoretically driven perspective. In the second stage, we will create an integrated neurocognitive model of motor learning representation for the elderly using advanced supervised machine learning with real EEG and behavioural data. Lastly, we will create and pilot an individualised intervention based on the model in the second stage, that targets cognitive control using meditation, and physical parameters with progressive chunk scaling approaches to drive greater learning outcomes in a shorter timeframe for the elderly. The results from this project have the potential to change health management policies and future applications of advanced brain computer interfaces.

Keywords: motor sequence learning,attention,memory,cognitive control,meditation,cognitive states,discrete sequence task production,representational similarity analysis
Develop and validate appropriate and acceptable outcome measures in intermediate age-related macular degeneration for future interventional clinical trials - Sofia ref.: 116076 (MACUSTAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Switzerland,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal
Call: DRY AGE-RELATED MACULAR DEGENERATION: DEVELOPMENT OF NOVEL CLINICAL ENDPOINTS FOR CLINICAL TRIALS WITH A REGULATORY AND PATIENT ACCESS INTENTION (H2020-JTI-IMI2-2015-07-two-stage, 2015)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 16218917.97
EU funding (EUR): 8025000.0
Participants: 19
Project status: SIGNED

Despite significant advances in the treatment and understanding of late stage age-related macular degeneration (AMD), it continues to be the main cause of irreversible severe visual loss in Europe and its prevalence and incidence will increase with current demographic trends. In order to reduce the significant burden of late stage AMD, novel interventions should aim at stopping or delaying progression from the preceding disease stage intermediate AMD (iAMD) to late stage AMD. As a prerequisite, validated clinical endpoints for iAMD are needed. These should be acceptable to regulatory agencies, health technology assessment (HTA) bodies, and payers. Currently such endpoints do not exist for iAMD clinical trials (CTs). In addition, there is good evidence indicating that patients with iAMD experience some impairment of visual function yet it is unknown to what extend this impacts the patients’ life nor can it be reliably measured and quantified. It is also unknown whether there are specific risk factors in the population of iAMD patients which identify those with more rapid progression to late stages of the disease. Therefore, to enable successful development of iAMD interventions validated functional, morphological and patient--reported endpoints for CTs, which are clinically meaningful and accepted by regulatory agencies, are required. In addition, functional decline in iAMD, as well as, specific risk factors for iAMD progression to late stage AMD need to be better characterized to inform and improve conduct of future iAMD CTs. Against this background, the major objective of MACUSTAR is to develop novel clinical endpoints for CTs with a regulatory and patient access intention in patients with iAMD. Additional objectives are to characterize visual impairment in iAMD and its progression, as well as, identify risk factors for progression. For clinical endpoint development, functional, structural and patient-reported outcome measures will be assessed with regards to

Keywords: age related macular degeneration,clinical endpoint,validation,retinal imaging,functional testing,patient reported outcome
NEXT GENERATION BPM TO MAKE AUTOMATIC DECISIONS (FlowForma BPM-CDL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FlowForma is an Irish SME leading provider of Business Process Management (BPM) tools for Microsoft Office 365® developing BPM products that empower users to get work done, smarter and faster, on the familiar SharePoint platform, without any coding. FlowForma BPM-CDL has been conceived as the next generation of their award-winning FlowForma BPM (Business Process Management) that supports Collaborative Decision Learning (CDL). FlowForma BPM is a no-code, Microsoft Office 365 Add-In that enables business users and Heads of Departments to quickly and flexibly implement processes such as Human Resources (HR) on-boarding, new product development and clinical trials, making processes 10x more efficient and increasing productivity. Sitting on the SharePoint platform, the FlowForma BPM tool incorporates forms, workflow, document generation and decision making all in one place. FlowForma BPM-CDL functionalities will leverage the latest technologies of machine learning to assist decision-makers in considering different courses of thinking and learn from the decisions already taken. The goal is providing informed insights to aid the final decision process by learning from trends on business decisions over a given period of time. This will help reduce the risk of human errors and increase the efficacy of group decisions. FlowForma BPM-CDL will include new Digital Process Groups which will assist business end-users to maximize the efficacy of decisions (40%) and reduce human error (33%), while at the same time facilitating to increase process efficiency (10x) and productivity (50%). FlowForma BPM-CDL fits perfectly the market strategy of FlowForma, allowing us to reach outstanding market turnover figures during the period 2020-2024. Our initial estimated global sales in that period will reach a figure of €7.5 Million, obtaining a ROI of 1.148% and a CAGR of 63% in five years.

Keywords: business process management,collaborative decision learning,platform,decisions,process
Genome sequences from extinct hominins (100 Archaic Genomes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 2350000.0
EU funding (EUR): 2350000.0
Participants: 1
Project status: CLOSED

Neandertals and Denisovans, an Asian group distantly related to Neandertals, are the closest evolutionary relatives of present-day humans. They are thus of direct relevance for understanding the origin of modern humans and how modern humans differ from their closest relatives. We will generate genome-wide data from a large number of Neandertal and Denisovan individuals from across their geographical and temporal range as well as from other extinct hominin groups which we may discover. This will be possible by automating highly sensitive approaches to ancient DNA extraction and DNA libraries construction that we have developed so that they can be applied to many specimens from many sites in order to identify those that contain retrievable DNA. Whenever possible we will sequence whole genomes and in other cases use DNA capture methods to generate high-quality data from representative parts of the genome. This will allow us to study the population history of Neandertals and Denisovans, elucidate how many times and where these extinct hominins contributed genes to present-day people, and the extent to which modern humans and archaic groups contributed genetically to Neandertals and Denisovans. By retrieving DNA from specimens that go back to the Middle Pleistocene we will furthermore shed light on the early history and origins of Neandertals and Denisovans.

Keywords: genomics,ancient dna,neandertal,denisovan,population genetics
Citizens exposed to dissimilar views in the media: investigating backfire effects (EXPO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1499384.0
EU funding (EUR): 1499384.0
Participants: 1
Project status: SIGNED

In Europe, understanding and respect for those who hold different opinions are needed more than ever. In this context, exposure to dissimilar content in the media is crucial because encountering views that challenge one’s beliefs is hoped to foster tolerance. More and more scholars are interested in media diversity and more and more policymakers encourage citizens to see dissimilar views in the media. However, exposure to difference can also do harm, increasing conflict among citizens with different opinions (backfire effects). Despite these dangers, we lack a comprehensive model that explains when and why exposure to dissimilar views amplifies or attenuates hostilities. What encourages people to see dissimilar political content, on which issues, and in which media? Under what conditions, for whom, and why does exposure to dissimilar views backfire? What can be done to minimize the harms and maximize the benefits of encountering difference? This project addresses these questions. It will advance an evidence-based theoretical model that identifies the individual, social, and system factors that together drive dissimilar exposure and its effects on understanding and respect between citizens with different views. This model accounts for old and new media, various political issues, and intended and incidental exposure.The model will be tested in four projects, each offering methodological breakthroughs. I will use latest techniques in ‘big data’ research, automated content analyses, panel surveys, qualitative work, and experiments; the first project to use this necessary variety of cutting-edge techniques conjointly and comparatively. This project will advance academic knowledge. Its findings are crucial for scholars across disciplines, policymakers who optimize media diversity policies, and media and campaign designers. Only if we know when, how, and why citizens are affected by dissimilar media will we be able to enhance respect and understanding in diverse societies.