Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Biomic_AUTh, Center of Excellence in Metabolomics research (BiACEM)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Spain,United Kingdom,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-12-01
End date: 2026-02-28
Duration (months): 39.0
Total project cost (EUR): 1226702.5
EU funding (EUR): 1226702.5
Participants: 4
Project status: SIGNED

BiACEM aims to link Biomic_AUTBiACEM aims to link Biomic_AUTh an interdisciplinary laboratory of the Aristotle University Thessaloniki, with three world leading metabolomics research groups: the bioinformatics team of Imperial College London, the metabolomics/lipidomics research team Fundación Universitaria San Pablo CEU (Madrid) and HMGU. Via the realization of the project, strategic partnership and networking will be developed, promoting the research status and capacity of Biomic researchers and covering existing gaps in know-how and technology. Long term aim of Biomic is to lead, develop new concepts, analytical methods, and ways to produce or analyze comprehensive datasets, furthering the application of metabolomics in life science and biomarker discovery. To reach this level, existing pinch points should be addressed. Themes identified as strengths of the advanced partners and key areas of Biomic improvement include: development and organisation of lipidomics experimentation in LC-MS, exploitation of advanced mass spectrometry acquisition and ion mobility spectrometry data, metabolite identification, effective mining and use of multiple data sets, data management, artificial intelligence tools for metabolomics data and for text mining (natural language processing), data fusion, effective biochemical interpretation. Transfer of knowledge is organised as a series of training events, webinars, e-meetings, staff exchanges and collaborative research with the advanced partners. Emphasis is also put on training on research management and setting a research management unit in Biomic. Three clinical biomarker discovery demonstration projects constitute the research element of BiACEM. Realization of the project will have major impact on Biomic, their collaborators and the Greek metabolomics ecosystem as it will remedy weaknesses, and provide new, timely and necessary technological solutions for the first time to Greek scientists, promoting level or research and innovation.

Keywords: disease biomarkers,data mining,biomarker discovery,metabolite identification,metabolic profiling
Rational development of nanocrystalline drugs for skin administration (Crystals4Skin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Brazil
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 2
Project status: CLOSED

Alternative drug delivery is one of the most promising solutions for an increasing number of geriatric and cancer patients heavily challenged by the oral route treatment. Crystals4Skin project targets skin as a pathway for local/systemic therapeutics, bringing ground-breaking approach at the cutting edge of biotechnologies. So far, only particle-size nanomaterials have been explored and used for the skin application. Extreme potential of the crystal form and surface diversity has not been considered as the source of a product innovation for healthier society yet. Crystals4Skin aims to fill the gap in current state of knowledge by the innovative research of nanocrystals-skin interaction through the integration of structure-to-property-to-function principles bridging chemical matter and biology. With cocrystals selected as the models allowing the study of different composition, bulk and surface characteristics, the research will employ the highest knowledge from the fields of crystal structure analysis, simulations, synthesis, physical-chemical characterisation, permeation, and toxicity studies. Targeting Beating Cancer Plan, one of the EU´s flagship initiatives, together with the United Nation´s Good Health and Well-Being sustainable development goal, Crystals4Skin brings together experts in crystal engineering, pharmaceutical technology, and nanomaterials for biomedical applications to answer the burning question: Is it only the size that makes the nanocrystals an extremely promising material of the future or are there other structural attributes driving their performance within the skin? Crystals4Skin aims to find the answer and meet the current discussions between regulators, academics and industrial parties on the control and use of safe and efficient nanomedicines.

Keywords: skin drug delivery,nanomaterials,nanocrystals,crystal engineering,nanomedicine,permeation,cytotoxicity
Sustainable, decarbonised vanadium, titanium and iron extraction from Europe’s low-grade vanadium-bearing titanomagnetite deposits (AVANTIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Belgium,Finland,Norway,Greece,Poland,Spain
Call: Innovative technologies for sustainable and decarbonised extraction (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5392257.45
EU funding (EUR): 5113069.95
Participants: 13
Project status: SIGNED

The EC’s Critical Raw Materials (CRM) Act sets multiple benchmarks for reducing Europe’s dependency on a few unlike-minded third countries for strategic/critical raw materials. Through the domestic extraction of two CRMs – “vanadium” (V) and “titanium metal” (Ti metal) – AVANTIS addresses the first target of the Act (> 10% domestic extraction, for V & Ti). AVANTIS’ rationale lies in the fact that Europe has a multitude of unexploited, low-grade V-bearing titanomagnetite deposits in Finland, Sweden, Greenland, Norway, Poland, Ukraine… However, these deposits have a complex “spiderweb-like” mineral assemblage. Without selective blasting, selective fragmentation and pre-concentration technologies to separate the Ti-rich ilmenite grains from the V-bearing magnetite, it is uneconomic to exploit these deposits. Supported by a bespoke forensic geometallurgy approach, AVANTIS develops a novel selective blasting approach that allows for rock excavation in view of increased mineral liberation at the blasting stage, and reduced energy demand in the crushing & grinding stages. Likewise, AVANTIS designs tailored, water-free and water-lean pre-concentration technologies that allow to produce two distinct pre-concentrates ((1) ilmenite-rich, Ti-pre-concentrate and (2) ilmenite-free, V-pre-concentrate). The water-lean method is also tailored to process V/Ti-bearing mining wastes from historical/on-going operations. The resulting flowsheets have a low net water consumption (> 70% water recycling) and reduced GHG intensity of extraction (reduction of 60–700 g CO2,eq per t ore hauled to the crushing plant). A preliminary analysis of the potential European reserves that are unlocked, yields a total of 154 Mt Ti & 3.5 Mt V (still excluding Ukraine), to be compared with current levels of EU consumption (1.5 Mt/y Ti; 12.7 kt/y V). AVANTIS strengthens the “responsible mining in Europe”-paradigm, increasing society’s trust in domestic CRM production.

Keywords: critical raw materials,extraction,selective blasting,selective fragmentation,advanced pre concentration,vanadium,titanium,phosphate,rees,lca,tea
Digging Deep into the Sequence Space of Electrochemical Debonding of Peptides to Impact Next Generation Polymer Adhesives (IDefix)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 2499995.0
EU funding (EUR): 2499995.0
Participants: 1
Project status: SIGNED

Generating novel polymer functions based on rational design criteria, derived from deep statistical analysis of massive experimental data sets, would fundamentally impact materials development and represent the next evolutionary step in macromolecular engineering. The IDefix project establishes a generic information-based design strategy to define polymer–surface interactions that represent the key property in various applications. The project focuses on advancing adhesives, to facilitate material-specific adsorption and triggerable desorption by distinct electrochemical transformations. The rationale of engineering such polymers is extracted from peptide phage display (PD) biopanning with an advanced selection scenario and using next-generation sequencing (NGS). This allows to screen 10^9 sequences and readout of 10^6, providing the data sets to feed machine learning (ML) tools. A new software tool “SurPhage” is developed and tailored to the material-oriented biopanning. Leveraging ML concepts, sequence data interpretation and feature abstraction are combined with sequence-function data of a broad analysis pipeline to learn on the rationale that feeds generative models for in-silico design. The underlying chemistry relies on peptides with L-3,4-Dihydroxyphenylalanin (Dopa)-residues that show potent catechol anchors and a unique debonding mechanism on quinone oxidation. However, the strategy enables to identify hidden champions and discover novel Dopa-free mechanisms. Employing the design rationale an IDefix platform is developed, covering polymers from artificial adhesive proteins to copolymers. These enable the electrochemical manipulation of adhesives, coatings or membranes, facilitating applications of debonding on command or dimming of permeability. Combining IDefix materials with piezoelectric elements leads to self-reinforcing mechano-responsive composites and integrating in near-field communication devices enables remote controlled drug release patches.
Demonstration of CAPEX- and OPEX-efficient hydrogen fuel cell-powered inland shipping using swappable H2Tank-Tainers and building an H2 ecosystem in and around ports (CleanH2Shipping)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Italy,Germany,Netherlands,Belgium,France
Call: Demonstration of hydrogen fuel cell-powered inland or short sea shipping (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 7194985.51
EU funding (EUR): 5770214.33
Participants: 11
Project status: SIGNED

The ambitious CleanH2shipping project unites ports, research organisations, technology providers and a ship operator, with the aim of developing and implementing a viable hydrogen ecosystem and showcasing the potential of hydrogen fuel-cell-powered inland and short sea shipping. Our vision extends beyond mere demonstration; we aspire to catalyse widespread adoption across Europe and beyond. Unlike land-based hydrogen applications for vehicles, there are no international regulations for safe use of hydrogen at sea, rivers or in ports. The volume required to power marine vessels is of an entirely different magnitude compared to road transport vehicles, and any potential accident could have far-reaching consequences. This lack of regulations is one of the main barriers to implementing hydrogen at scale, as shipbuilders, ports, shipowners, and logistics providers require clarity before committing to a new technology. Another major barrier are high investment costs for the production and port infrastructure and high operating costs of hydrogen-powered vessels. To realise the vision of hydrogen-powered shipping, CleanH2Shipping will engage policy makers and authorities to advocate for harmonised regulations, demonstrate the complete hydrogen supply chain and create a blueprint for replication in other European ports and ships. Innovative swappable hydrogen fuel tank containers, "H2Tank-Tainers," will be used, hence no investment in port infrastructure is required. Our demonstration with the 610 TEU inland container ship Letitia, featuring a 1.2MW fuel-cell main drive, will showcase sustainable shipping. Further standardisation, efficiency enhancements, scaling and AI-based container logistics will further decrease CAPEX and OPEX costs to build an H2 ecosystem. With our goal to lay the foundation of a H2 ecosystem in and around the European ports, this project can make a significant contribution to achieve the “Fit for 55” goals and significantly reduce CO2 emissions

Keywords: fuel cell,hydrogen,hydrogen based shipping,inland water transport,short sea shipping,decarbonisation h2 ecosystem,h2tank tainer,swappable fuel tank container
MODular and EXpandable multi-locus Transcranial Magnetic Stimulation (MODEX-mTMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

We aim to develop and validate a versatile and affordable transcranial magnetic stimulation (TMS) system that can perform adaptive and automated brain stimulation. TMS is performed routinely in thousands of hospitals worldwide for diagnostics (e.g., to measure corticospinal excitability), for presurgical planning (to locate eloquent brain areas that should not be harmed), and for treating severe depression and neuropathic pain. Unfortunately, only about 50% of patients benefit from the treatment; the treatments are also very time-consuming. Current TMS protocols are user-dependent, non-personalized, and stimulate only one brain target at a time; furthermore, target searches can take up to 10 minutes. When only one cortical node is stimulated, networks are difficult to modulate. Therefore, we need stimulus sequences that activate precise cortical nodes in specific networks involved in different disorders such as depression, addiction, or neuropathic pain. This can be done with so-called multi-locus TMS (mTMS), which we have developed in the ongoing ERC Synergy project ConnectToBrain, but the barrier to users purchasing mTMS is often the high cost. In this project, we will introduce a minimum viable prototype, an affordable 3-channel entry system for mTMS that enables efficient clinical protocols, provides operator independence, and saves time in patient care, with the potential to improve the clinical outcome. We aim to demonstrate the viability and value of this 3-channel device, which can later be expanded to a larger one simply by adding electronic modules and new coil sets. We intend to demonstrate the speeding up of motor cortex hotspot search by a factor of 5–10 and to show experimentally that the new multi-locus technology will markedly improve the efficacy of inducing plastic changes in the target network.
Design and Characterization of a Compton Camera Using 3D-CZT Detector Modules with Advanced Signal Processing and Polarimetry for MeV Astrophysics (COMPOL-3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-04
End date: 2028-05-03
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

The energy range between 0.1 MeV and 10 MeV is called as “MeV gap” in astronomy, primarily due to the low sensitivity of the instruments in this energy range. Compton imaging is the key technique proposed to overcome this challenge. The goal of this project is to design a cost-efficient Compton Imager. CZT detectors have the potential to be game changers when used in a Compton Imager, since they offer good energy resolution at room temperatures. Hence in this project, we plan to design, simulate and calibrate a Compton Camera based on the 3D-CZT Drift Strip Detectors, developed previously at DTU Space, Technical University of Denmark. An additional advantage is that the Compton Imager could be used as a hard X-ray polarimeter, as azhimuthal angle of the Compton scattering depends on the polarization of the incoming photon. Recent observations from the Imaging X-ray Polarimetry Explorer (IXPE) have attracted massive interest from the high-energy astrophysical community towards X-ray polarimetry. However, IXPE operates in the soft X-ray band of 2-8 keV, where the thermal processes interlap with non-thermal processes. Hence, a polarimeter in the MeV band where the non-thermal radiative process dominates is of large interest. We plan to design a laboratory model of the Compton telescope using a stacked configuration of 3D CZT detectors and evaluate its imaging and polarimetry performance through simulations followed by experimental validation. The recent development of this detector includes using Artificial Neural Networks for sensor Signal Processing and Real-time measurement of radiation interactions which would also be ideal for this project. The immense expertise of the host supervisor and group in semiconductor detectors would complement the candidate's experience in X-ray polarimetry to accomplish the project.

Keywords: x ray detectors,space instrumentation,x ray polarimetry,high energy astrophysics
Novel optical display technology based on MEMS and metasurface structural colors targeting sustainable displays for consuming electronics (OPTICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: CLOSED

The OPTICS project aims to improve the recent reported display technique of MEMS (Microelectromechanical systems) metasurface structural colors (applicant’s previous work), through re-designing the color filers and the MEMS cantilevers, for practical display applications for consuming electronics. The proposed technology combines transmission-based plasmonic structural colors with MEMS micro cantilevers to realise full range RGB displays, while using only two common earth-abundant materials: Aluminum (Al) and silicon oxide (SiO2), potentially for cost effective products and fast operation performance. Optical displays play a ubiquitous role in daily life, being an essential component of smartphones, computers, televisions, etc. However, these devices make up roughly half of the 50 million tons of e-waste produced globally every year. In estimate, 40 million tons are generally ending up in burn pits or landfills in developing countries, causing environment and health problems. There is an urgent need for alternative display technologies which are easier to recycle and are financially feasible to be incorporated into sustainable consumer electronics. Structural colors could be an ideal technology for next-generation optical displays. Several reports have been published on controllable / tunable structural colors towards optical displays. However, none of them meet the basic requirements, namely: control individual pixel by voltage, control color of individual pixels, and control brightness of individual pixels. We will examine a new type of optical display technology based on structural colors and MEMS to meet the above requirements. Implemented at the University of Southern Denmark, this project will allow the fellow to enhance both scientific and communication skills, through a well-designed training program (courses, workshops, regular meeting with supervisors), a data management plan, as well as measures for knowledge exchange and dissemination/communication.

Keywords: mems,metasurface,structural colors,optical display,micro nano fabrication
MODULAR ELECTRICAL GENERATOR PTO SYSTEM FOR WAVE - MEGA PTO WAVE (MEGA WAVE PTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Greece,Portugal,United Kingdom,Italy,Germany,Belgium,Ireland
Call: Development of innovative power take-off and control systems for wave energy devices (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 2205635.88
EU funding (EUR): 2105638.08
Participants: 12
Project status: SIGNED

The world faces the challenges of transitioning to net zero emissions to combat climate change, requiring a shift from fossil fuels to renewable energy sources, like wave energy. Yet, the integration of wave energy into the global energy mix is not without hurdles. Harnessing the power of ocean waves requires innovative and reliable technologies that can withstand the harsh marine environment while ensuring consistent energy generation. Moreover, the pursuit of sustainable energy production extends beyond emissions reduction, to embrace circular economies. Circular economies advocate for a holistic approach where resources are continually reused, repurposed, and recycled, thus minimising waste and maximising resource efficiency. For the wave energy sector, this means not only developing efficient power take-off systems but also considering the lifecycle impacts of materials, manufacturing, installation, operation, and decommissioning. The MEGA PTO Wave project aims to provide an enabling technology to transform ocean waves into clean, reliable energy. Through this project, a smart, scalable system will be created that adapts to changing conditions and keeps working even if a part of the system experiences a fault. By designing all aspects of the MEGA PTO to be highly modular, incorporating novel axial flux magnetic gear, electrical generator technology and adaptable power electronics, the project will make energy production more efficient and eco-friendly. This modularity creates a system that is easier to manufacture, transport, install, maintain, remove and recycle, than alternatives. The MEGA PTO Wave project brings together expertise from all over the EU to create a PTO linked to sustainable supply chains, to accelerate wave energy commercialisation to capture vast amounts of predictable energy in a sustainable and cost effective manner, in order to meet EU NetZero targets by 2050.

Keywords: magnetic gears,permanent magnet generator,power electronics,condition monitoring,control systems,