Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multi-omics characterization of immune triggers in Moyamoya disease (MULTIMOYA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1981593.75
EU funding (EUR): 1981593.75
Participants: 1
Project status: SIGNED

This project aims to characterize a recently discovered link between a rare genetic disorder of the brain, called Moyamoya disease (MMD), and the cellular immune response against microbial infections. MMD is characterized by a progressive occlusion of arteries at the base of the brain leading to stroke. Mutations in Ring Finger Protein 213 (RNF213) represent the most common genetic cause of MMD, however, it is suggested that environmental stimuli are needed to trigger disease onset in genetic carriers. Intriguingly, we recently discovered RNF213 as a novel antibacterial protein that can target intracellular Listeria (Gram+), providing strong protection to Listeria both in vitro and in vivo. Similarly, RNF213 can bind intracellular Salmonella (Gram-), mediating its ubiquitin-dependent degradation. Moreover, we also identified RNF213 as a cellular sensor for proteins modified by ISG15 (ISGylated proteins), a ubiquitin-like modification of the immune system induced by interferon. These observations not only uncover RNF213 as a novel key antimicrobial protein, they also suggest an important role for the immune system in triggering MMD. MULTIMOYA starts from the hypothesis that dysregulated immune responses to infections might trigger MMD disease onset in patients carrying mutations in RNF213. To investigate this hypothesis, we will determine whether MMD patient-derived immune cells respond differently to interferon, LPS or bacterial infection by mapping altered pathways using a multi-omics approach, combining genomics, transcriptomics, proteomics and (tracer) metabolomics data. Results will be validated by biochemical and imaging analysis in relevant patient-derived/like cellular models as well as in mouse models of MMD that we will establish. Together, these experiments will provide unprecedented insight into MMD-related immune responses and fundamental processes that link cellular immunity with vascular disease.

Keywords: stroke,infection,immune response,transcriptomics,proteomics,metabolomics
Post-Repatriation: Collaborative Methodologies to Enhance Multivocality (Collab4Multi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-15
End date: 2025-04-14
Duration (months): 31.0
Total project cost (EUR): 263638.8
EU funding (EUR): 263638.8
Participants: 3
Project status: CLOSED

The research project ‘Post-Repatriation: Collaborative Methodologies to Enhance Multivocality’ (acronym: Collab4Multi) speaks to the Indigenous research methodologies and partnerships in community-based research in academia and beyond. It strives to explore the recently recovered archaeological material from the Nunalleq site (1400-1675 AD) in southwest Alaska in close collaboration with non-academic research partners, including Indigenous artists and young culture bearers. The pre-colonial history of the Yup'ik is poorly known from the archaeological point of view: most of what we know about it comes from the Nunalleq site. It is therefore important that the interpretations of the Nunalleq collection be multivocal and produced combining the strengths of Western archaeological science with Indigenous knowledge systems and worldviews. Advocating for multivocality and decolonisation of academic research, this project will critically analyse the re-socialisation of cultural heritage in and by the living community. The research programme of the project rests on a series of arts-based workshops to study this world-class collection of Yup’ik people and (re)create the life-stories of its artefacts together with Indigenous research partners. The project will also explore the collaborative ways of knowledge co-production and dissemination by developing and piloting co-writing methods informed by Indigenous epistemologies. The practical outcomes will contribute to the advancement of collaborative methodologies in archaeological and museological research with and for Indigenous communities across the Arctic region.

Keywords: community based archaeology,indigenous people,indigenous knowledge,decolonising methodologies,repatriation,cultural heritage
quantum electro-optic amplifiers for the next generation quantum and supercomputers (Q-AMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1930736.0
EU funding (EUR): 1930736.0
Participants: 1
Project status: SIGNED

Quantum computers face many bottlenecks towards upscaling the number of qubits and increasing their computational power. One of them is the radio frequency (RF) -bottleneck between the qubit processor inside the cryostat and the room temperature control and readout electronics. And like for their classical counterparts, hope lies in replacing the RF-links by optical fibers, resulting in a hybrid situation where RF-qubits will be used for computation and optical qubits will serve for remote communication. However, electro-optical (EO) devices that parametrically amplify RF-qubits directly to optical qubits and vice versa have thus far remained elusive. Q-Amp will demonstrate a new class of EO-amplifiers that realize the required unity efficiency to achieve this goal. This is impossible with current EO-architectures which suffer from a deleterious trade-off between EO interaction strength (g) and EO losses (Q-factors). This originates from their device design and enhancing g requires bringing the RF-superconducting circuit in close vicinity of the optical waveguide, which comes at the expanse of excess EO losses. To cope with this, we will pioneer a transparent EO device technology that enhances g without the need of bringing superconductors and optical waveguides in close vicinity of each other. We will do so by concentrating the RF- and the optical field in the same nanoscale interaction volume via dipolar screening in ferroelectrics and/or ballistic transport in graphene. Confining both fields within next generation EO-materials will enable an increase of g from 100s of Hz (prior art) to Megahertz-levels. Simultaneously, light is kept away from the lossy superconducting electrodes enabling moderate Q-values of 1E5..1E6. Q-amp’s EO-amplifiers will finally overcome the scaling limitations of current superconducting quantum computers and will provide classical superconducting supercomputers with high-speed EO gateways they desperately need.

Keywords: integrated electro optical transducers integrated electro optical parametric amplifiers single photon conversion
centRe of Excellence in AerosoL remote rensIng technology and Science in The Indian oCean (REALISTIC)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: France,Spain
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2494375.0
EU funding (EUR): 2494375.0
Participants: 2
Project status: SIGNED

The overarching goal of REALISTIC is to develop a Centre of Excellence in aerosol remote sensing technology and science in the Indian Ocean, through the creation of a Chair, with La Réunion, a European Outermost region, as a strategic pivot point of the European Research Area. REALISTIC aims at attracting and maintaining a high-profile researcher (ERA Chair holder) to lead a high profile supporting team with excellent research and technical capabilities in the aerosol remote sensing domain. In particular, specific applications and research endeavours will be conducted in the area of quantifying the impact of wildfire and volcanic emissions on the tropical atmosphere composition and on the Earth-Atmosphere radiative balance. REALISTIC is designed to catalyse and maximise the impact of the ERA Chair in order to raise the research, technical and innovation excellence of the Laboratory of Atmosphere and Cyclones (LACy), the Observatory of Atmospheric Physics of La Réunion (OPAR), the Observatory of the Universe Sciences of La Réunion (OSU-R), and the University of La Réunion (UR) to a level that makes them unique and essential references in the local R&I ecosystem, at the Indian Ocean-level as well as to the overall international community, and thus filling the R&I gap on atmospheric systems. REALISTIC will contribute to better integrate UR within the European Research Area, and better align with European standards and priorities.

Keywords: brain gain,capacity building,better use of infrastructure,institutional reforms,mobility,la r union
Bridging Risks to an Inclusive Digital and Green future by Enhancing workforce Skills for industry 5.0 (BRIDGES 5.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Austria,Greece,France,Spain,Lithuania,Italy,Norway,Ireland,United Kingdom,Germany
Call: Workforce skills for industry 5.0 (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4604616.25
EU funding (EUR): 4604616.25
Participants: 21
Project status: SIGNED

BRIDGES 5.0 bridges risks to an inclusive digital and green future by enhancing workforce skills for Industry 5.0. To achieve this ambition, four objectives are central: (1) Quantitatively map how jobs are transforming and what new green and digital jobs are emerging in Industry 4.0; and qualitatively understand Industry 5.0 requirements (human- and socio-centric, sustainable and resilience) for these jobs and company practices; (2) Map Industry 5.0 skills and skill gaps at the EU-level and five EU-institutional contexts for emerging green and digital jobs; and enable monitoring of skill gaps using skills taxonomies/standards; (3) Set up learning trajectories and training pathways, using the enriched Teaching and Learning Factories concepts, and experiment with these interventions to reduce skill gaps for four target groups, i.e. managers, employees, jobseekers and students; (4) Engage a range of industry and related stakeholders at regional, national and EU levels and co-produce a web platform called Industry 5.0 Platform. The platform facilitates social innovation in the learning field and provides these stakeholders and target groups with recommendations and instruments for new learning and training systems. The outcomes contribute to the right supply of skilled workers who will enable companies to optimise the gains from digital technology and the right skills to deal with the digital and green transition to achieve a sustainable, resilient and fairer future for Europe. Stakeholders commitment is crucial to the success of Industry 5.0 and BRIDGES 5.0 creates a unique consortium collaboration between researchers, 8 EU-industrial companies, 9 Industry 4.0 ecosystems and the main EU social partners. An interactive process is created between stakeholders to align with their differing interests and the research results, produced in 7 steps, will be a vital resource for the stakeholders. A business plan supports the sustainability of the Industry 5.0 Platform.

Keywords: technological transformation industry 5 0 digital skills workplace innovation
The STE(A)M Education European Roadmap (The SEER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Belgium,Italy,Cyprus,Greece,Netherlands,Germany
Call: Developing a STE(A)M roadmap for Science Education in Horizon Europe (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1749035.0
EU funding (EUR): 1749035.0
Participants: 6
Project status: SIGNED

The SEER - The STE(A)M Education European Roadmap, is an improvement journey with different stages associated to intervention steps based on research and proven experiences with recommendations, to get more STE(A)M-happy motivated and connected citizens. The SEER will be at the intersection of four major dimensions: (1) the need to collect all that currently is in place (such as STE(A)M education policies, innovative STE(A)M teaching practices, and feedback on how existing STE(A)M programs were implemented so far), (2) the importance to foster exchange and dialogue among all STEAM education stakeholders, (3) the necessity to permanently carry out needs analysis activities that would identify gaps, as well as impact analysis of initiatives and policies and (4) provide guidance for future actions and get the buy-in of citizens and particularly major stakeholders (Ministries, schools, parents, teachers) through outreach mechanisms. The SEER will deliver: a) The SEER process: including focus groups, seminars and case studies with supporting surveys, polls, and results, leading to the identification of gaps and the STE(A)M Education European Roadmap; b) The STE(A)M Education European Roadmap: The Atlas of roadmaps that will help improve STE(A)M Education from different stakeholders starting point and using a myriad of paths depending on the goal to achieve; c) The STE(A)M Education European Roadmap Impact Strategy providing a standard impact assessment mechanism for new STEM plans, projects, and initiatives; d) A proposal of how an Integrated STE(A)M education certification framework could contribute to educational reform, why it is relevant for students, teachers, citizens and MoEs, and how schools can self-evaluate. Additionally, to continuously engage the community at large on the options and benefits of STE(A)M in our lives and their connection to a better / greener world, and future degrees and careers, SEER will run an ambitious series of dissemination actions.

Keywords: contextualization of stem teaching,stem careers,education continuum,policy makers,ministries of education,teachers,researchers,industry,ste a m,integrated ste a m teaching
Barium in the Southern Ocean Indian Sector (BaSIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Barium (Ba) has been proven to be a particular useful tool to estimate organic carbon remineralization in various areas of the world’s ocean. To date, however, the Ba cycle and its budgets in the ocean are not well constrained. Indeed, in the ocean, sources of Ba from hydrothermal alteration and deep-sea sediments, but also the internal Ba cycle are hard to constrain with Ba concentrations alone. The use of Ba isotopic composition (138Ba) measurements can provide meaningful insights on these sources and processes. Specifically, different inputs and different biological processes influencing the Ba distribution in the ocean have distinct 138Ba. However, surveys of 138Ba, in seawater and particles in the Southern Ocean (SO) has never been made. It is particularly important to understand the impact of the SO on the Ba cycle, as any preformed Ba or other sources of Ba in the SO would have a large impact on its use as a remineralization tracer in the global ocean. BaSIS is thus a unique opportunity to enhance knowledge on the Ba cycling in this key oceanic region by studying 138Ba in seawater and marine particles from the GEOTRACES cruise SWINGS in the SO. The fellow will spend the first two years at the Laboratoire de l’Envionnement Marin (LEMAR) under the supervision of Dr. Planquette. This fellowship will allow her to come back to Europe with the technical expertise she acquired outside of the EU in the past years. She will implement a new technic and will acquire a unique overview of the Ba cycle in the global Ocean. Research results will be of interest to worldwide researchers working on the study of the impact of the global carbon cycle, promoting European excellence and competitiveness in dedicated European and international carbon export projects.

Keywords: oceanography,marine chemistry
Beyond the hydrodynamics horizon in the evolution of small and large colliding systems at colliders (KineticTheoryQGP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark,Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

A hot expanding environment is produced in heavy-ion (e.g., lead-lead or gold-gold) collisions in the Large Hadron Collider (LHC) and Relativistic Heavy Ion Collider (RHIC). The produced system expands and cools down, turning from a phase with liberated quarks and gluons, called quark-gluon plasma (QGP), to hadrons, detectable in the detectors. The QGP behaves like a nearly perfect fluid that can be modeled via relativistic hydrodynamics with the smallest observed shear and bulk viscosity over entropy density. In the course of the collective expansion, the degrees-of-freedom interaction develops correlation, reflected in the correlation among final hadrons. Models based on hydrodynamics successfully describe the observed correlations in the experiments. Observing a similar correlation among final hadrons emitted from much smaller collision systems, e.g., proton-proton and proton-lead, has triggered debates about the nature of the collectivity in such scenarios. Studies show that the models based on hydrodynamics become less predictive in smaller system collisions. In these systems, one does not expect a thermalized medium, and a framework beyond hydrodynamics is required to explain the true underlying mechanism in collective expansion. The main objective of the current project is to prepare a computational tool in the form of an event generator based on the kinetic theory with isotropization time approximation. Among an extensive list of heavy-ion collective models, this event generator will be unique in explaining small systems that behave particle-like and large systems that act fluid-like in a single framework. The model can bridge the experimental measurements and theoretical studies to quantitatively analyze the fluid-like/particle-like nature of large and small system collisions.

Keywords: relativistic heavy ion collision,quark gluon plasma,kinetic theory
Risks, Resources and Inequalities: Increasing Resilience in European Families (rEUsilience)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Belgium,Sweden,Poland,Spain,Croatia,United Kingdom
Call: Providing support in a changing world of work and social protection (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 2317925.5
EU funding (EUR): 2317925.5
Participants: 7
Project status: SIGNED

The problem that rEUsilience tackles is of lack of adaptive capacities or resilience in some families. The context is of fast-paced changes in labour markets to which families are key responsive mechanisms, cushioning potentially negative impacts and enabling/disabling risk-taking. But some families cannot respond. The project answers 2 research questions: What challenges and difficulties are created or exacerbated for families by labour markets in the ‘new world of work’ and how do families try to overcome them? How do policies contribute to family resilience especially in terms of their inclusiveness, flexibility and complementarity? To answer these questions rEUsilience looks at what different families actually do in situations calling for adaptiveness (e.g., need to change labour supply, need to engage in training) and places this in a social and policy context through both pan-European analyses of existing data and new focus group research in 6 different countries (BE, ES, HR, PL, SE, UK). The project will identify the level of risk and socio-economic insecurity faced by families across Europe, their relative capacity to absorb socio-economic shocks and the role of policy. The project is organised in 2 pillars: a Stocktaking pillar and a Policy Lab. The pillars are designed to closely interlink in terms of evidence flow and mission, to share some methodologies and to have inbuilt pathways to impact. The Lab involves citizens and experts directly in policy review and problem solution and also uses simulations and other methods to road-test policy solutions. Among the outputs are: a compendium of the risk situation of Europe's families, a series of dynamic analyses of actual risk behaviour, accounts from families about how they view risk-taking and trade-offs between work and care, critical reviews of policies, a questionnaire on family resilience taken to proof of concept stage, a set of policy proposals and roadmaps for their implementation.

Keywords: family resilience,labour market risks,intersectional inequalities,diversity,policy effectiveness,care,gender,