Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE (rEnDOx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy,Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-07-01
End date: 2022-12-31
Duration (months): 78.0
Total project cost (EUR): 1999827.0
EU funding (EUR): 1696074.54
Participants: 2
Project status: CLOSED

Endothelial cells (ECs) exhibit a remarkable and unique plasticity in terms of redox biology and metabolism. They can quickly adapt to oxygen, nitric oxide and metabolic variations. Therefore, EC must be equipped with a selective and unique repertoire of redox and metabolic mechanisms, that play a crucial role to preserve redox balance, and adjust metabolic conditions in both normal and pathological angiogenesis. The identification of such redox signaling and metabolic pathways is crucial to the gaining of better insights in endothelial biology and dysfunction. More importantly, these insights could be used to establish innovative therapeutic approaches for the treatment of those conditions where aberrant or excessive angiogenesis is the underlying cause of the disease itself. However, the formation, actions, key molecular interactions, and physiological and pathological relevance of redox signals in ECs remain unclear. Here, by using cutting-edge real-time redox imaging platforms, and innovative molecular and genetic approaches in different in vivo animal models, we will (1) reveal the working of redox signaling in EC in health and disease, (2) shed light on the novel role for the mevalonate metabolic pathway in angiogenesis and (3) provide solid evidence, that manipulation of endothelial redox and metabolic state by genetic alteration of the redox rheostat UBIAD1, is a valuable strategy by which to block pathological angiogenesis in vivo. The ultimate objective is to open the way for the development of innovative (cancer) therapeutic strategies and complement the existing ones based on genetic or pharmacological manipulation of redox rheostats to balance oxidative or reductive stress in angiogenic processes. The success of this project is built upon our major expertise in the field of angiogenesis in small vertebrate animal models as well as on the collaborations with leading laboratories that are active in research on the pre-clinical stages for angiogenesis-rel

Keywords: redox signaling,zebrafish model,tumor angiogenesis
International IST Doctoral Program (ISTScholar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 8789760.0
EU funding (EUR): 4394880.0
Participants: 1
Project status: CLOSED

The Institute of Science and Technology Austria (IST Austria) is an English language PhD-granting research institute with focus on basic research in the natural and mathematical sciences. ISTScholar offers PhD training in biology, neuroscience, computer science, mathematics, physics and relevant interdisciplinary areas. The program is divided into two distinct phases: Phase 1 is dedicated to course work and rotations. The curriculum is designed to provide a foundation both broad and deep enough to support thesis research across a wide spectrum of cutting-edge research problems. Students have to fulfill a breadth requirement by taking courses outside their own field. Throughout the courses, interdisciplinary approaches will be encouraged through the formation of mixed teams of students. The translation between vocabularies in different disciplines will be emphasized. Students will not be directly affiliated to any research group, but will be supported through a mentor during the first phase. This uncommitted period offers the student the opportunity to work closely with several professors and make an informed choice about his or her future career path. Phase 2 is the period in which the student will primarily work on completing a thesis project. The scientific training will be accompanied by the Career Development Program. Workshop topics include science communication, career planning, time and self-management, and interpersonal skills. ISTScholar therefore offers courses in teaching didactics and there is a teaching requirement for all students. Intersectoral exposure will be guaranteed through the ISTInnovation program with workshops and talks to help translate research findings into innovations. The aim of ISTScholar is to educate a new generation of researchers who are able to approach scientific questions from different angles and are fluent in the languages of both the experimental sciences and analytical sciences.

Keywords: international scholars,phd granting research institute,basic research,new generation of researchers,scientific training and career development program,mentoring program
The First Global Renewable Trading Platform (Pexaconnect)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With Feed-in-Tariffs being replaced and grid parity achieved in many regions, today renewables are traded in the open market and have become investments that are significantly more complex, technical and volatile. Thus, the post-tariff market has created a major issue for many investors, who are having difficulty measuring and supervise the revenues of their assets. Corporate Power Purchase Agreements (PPAs) has emerged as an effective and vital new route to finance renewable energy assets, however structuring PPAs is quite complex, resulting to high search and transaction costs for market participants. In a market that is volatile, non-transparent and dependent on variables such as weather, renewable investors are in need of solutions to help them manage revenue and risks of their power sales. PEXA®connect disrupts how renewable energy markets are organized today. It introduces the first renewable energy trading platform that provides all pre-sales preparation services, as well as after-sales services to facilitate energy sales/PPA transactions at a fingertip. It introduces a new business model that accompanies investors through the entire PPA process and offers them an all-in-one solution to take control of their assets. In summary, it substantially increases market efficiency by reducing the currently very high search (counterpart) and transaction costs.

Keywords: renewable energy,fintech,energy trading,saas
Design Customized Support for Innovative SMEs (DCS-iSMEs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Greece
Call: Supporting experimentation in innovation agencies (H2020-INNOSUP-2018-06-two-stage, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 60000.0
EU funding (EUR): 60000.0
Participants: 1
Project status: CLOSED

The aim of this specific project is to set up a brand-new innovation support service –a service that will enable both the country make profit out of its investments on SMEs and the SMEs further develop their operations by enhancing the use of Design. Two closed groups will be developed; the first one will be a traditional group of 5 beneficiaries of previously implemented programmes, which will run the common procedure after finishing the implementation of their project –the Comparison Group. This group, just like all those beneficiaries till today, will have no contact/support by our organisation, after finishing their project. The second closed group will make use of the new innovation support scheme. A closed group of 5 SMEs –the “Treatment Group”– will be selected and they will be offered a Design Clinic service, a service that through which, they will fully understand their future challenges and which are their opportunities. They will be also offered some introductory workshops in order to understand the value of Design and its mindset. After the introductory workshops, they will receive a Design Customized Mentoring service –a service through which they will be provided guidance on how to strategically integrate design thinking in their products, services and operations. This is a new innovation support scheme, which seems more than needed. A call for expression of interest will be published targeting to SMEs that have already made use of a financial support programme. After selecting the Treatment Group, the project will directly call SMEs that will be monitored regarding their business indicators, and will not receive the new service, formatting the Comparison Group. This way, the project will assure that the two groups will be equivalent. The project will monitor both groups development rates and will come up with a feasibility study regarding the provision if the specific scheme, which intends to make permanent.

Keywords: design for innovation,smes support,smes sustainability,competitiveness
Uncovering and engineering the principles governing evolution and cellular control of bioenergetic organelles (EvoConBiO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Norway,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1417862.0
EU funding (EUR): 1417862.0
Participants: 2
Project status: SIGNED

Complex life on Earth is powered by bioenergetic organelles -- mitochondria and chloroplasts. Originally independent organisms, these organelles have retained their own genomes (mtDNA and cpDNA), which have been dramatically reduced through evolutionary history. Organelle genomes form dynamic populations within present-day eukaryotic cells, akin to individuals co-evolving in a "cellular ecosystem". The structure of these populations is central to eukaryotic life. However, the processes shaping the content of these genomes through history, and maintaining their integrity in modern organisms, are poorly understood. This challenges our understanding of eukaryotic evolution and our ability to design rational strategies to engineer bioenergetic performance. EvoConBiO will address these questions using a unique and unprecedented interdisciplinary approach, combining experimental characterisation and manipulation of organelle genomes with mathematical modelling and cutting-edge statistics. This highly novel combination of experiment and theory will drive the field in a new direction, for the first time uncovering the universal principles underlying the evolution and cellular control of mitochondria and chloroplasts. Our groundbreaking recent work on mtDNA suggests a common tension underlying organelle evolution, between genetic robustness (transferring genes to the nucleus) and the control and maintenance of organelles (retaining genes in organelles). EvoConBiO will reveal the pathways underlying organelle evolution, why organisms adapt to different points on these pathways, and how they resolve this underlying tension. In addition to these "blue sky" scientific insights into a process of central evolutionary importance, we will harness our findings to "learn from evolution" in high-risk high-reward development of new experimental strategies to engineer chloroplast performance in plants and algae of importance in EU agriculture, biofuel production, and bioengineering.

Keywords: mitochondria,chloroplasts,organelles,organelle genomes,genome evolution,genome engineering,mathematical biology,evolutionary pathways
Innovative nanocellulose bioplastic film from fruit waste (EcoFLEXY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cellugy has developed EcoFLEXY, a biopolymer from fruit waste. EcoFLEXY ready-to-use packaging films can be produced at a comparable cost to fossil plastics, due to an innovative “white biotechnology” production process: aerobic fermentation produces a unique, 100% pure, nanomaterial combining the positive attributes of cellulose with qualities such as extraordinary mechanical strength. Most food packaging solutions made from fossil-based plastics are produced and consumed in an unsustainable manner. They emit greenhouse gases during production and degradation; the majority of food packaging is intended for single-use, while it takes hundreds of years for the material to degrade; large volumes of food plastic packaging ends up as litter, resulting in high waste management costs and the pollution of our ecosystem; and plastics are entering the food chain with potential harmful effects on human health. There is an urgent need for bio-based alternatives. Given the emphasis that policy makers and consumers are placing on environmental issues, bio- based food packaging is likely to grow by 28.3% between 2018 and 2024. Related to the UN Sustainable Development Goals 2 and 12, Cellugy is taking action and facilitating the transition towards more sustainable food packaging solutions. EcoFLEXY is: produced from food waste (second-generation feedstocks); simple and cheap to produce through a near carbon-neutral production process; avoids microplastics pollution in the ocean; is home compostable and is recyclable in the existing system. By 2026, Cellugy aims to be a leading player in the €0.9bn global market for flexible packaging for the food industry with a market share of 2.4%. This feasibility study will permit Cellugy to confirm customer requirements for sustainable packaging, explore different food applications and specify target markets, validate the production process and identify the resources required to support growth.

Keywords: biopolymer,recyclable plastics
INNOVATION SERVICES FOR SMEs INNOVATION CAPACITIES ENHANCEMENT IN MADRID REGION (INNMADRIMASD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 70000.0
EU funding (EUR): 56000.0
Participants: 4
Project status: CLOSED

Lack of innovation management capacity is recognised as an important barrier to creating economic impact (competitiveness, growth and jobs) from innovation activities in SMEs. Consulting services in that area are not available to SMEs in many European regions as a result of lack of offer, unaffordable market prices or poor quality. To address this, this action shall provide specialized consulting services addressing innovation management capacity to SMEs which possess significant innovation activities. Beneficiaries of the SME instrument shall as well receive support to enhance their innovation management capacity through this action.

Keywords: innovation management,innovation services,business coaching,innovation support
Cosmic Fireworks Première: Unravelling Enigmas of Type Ia Supernova Progenitor and Cosmology through Strong Lensing (LENSNOVA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1992500.0
EU funding (EUR): 0.0
Participants: 2
Project status: SIGNED

The LENSNOVA project proposes a breakthrough both in cosmology and stellar physics, capitalising on 10 years of experience in the field of strong lensing time delays. Type Ia supernovae (SNe Ia) can now be watched on prime seats through strong lensing, where multiple images of the same SN appear at different times/locations around a foreground lens galaxy. After the first SN appears, the next SN occurrence (of the same SN event) can be predicted and observed in its entirety for the first time in history and with unprecedented temporal sampling. Observations of the beginning of SN explosions are key to revealing SN progenitors, that have been under debate for decades. Strongly lensed SNe Ia also allow an independent measurement of the Hubble constant (H0) that sets the cosmic expansion rate. The independent measurement is important to ascertain the possible need of new physics beyond the standard cosmological model, given the tensions in current H0 measurements. Capitalising on the PI’s expertise in strong lensing and success in predicting the reappearance of the first strongly lensed core-collapse SN, the objectives of LENSNOVA are to (1) place the best constraints on SNe Ia progenitors, and (2) pioneer the use of strongly lensed SNe Ia as a new cosmological probe. This will shed light on the natures of SNe Ia progenitors and dark energy, two of the greatest puzzles in the present era. The advent of the Large Synoptic Survey Telescope and the Euclid mission makes LENSNOVA particularly timely for building the first sample of ~5 strongly lensed SNe Ia. Accurate predictions of the time delays in lensed SNe Ia will allow multiwavelength observations of the reappearances of SNe, especially in the earliest days of explosion for the first time, to place the best constraints on SN progenitors. These lensed SNe Ia will also potentially yield an H0 measurement with 2% uncertainty. LENSNOVA has thus the potential to revolutionise both fields of stellar physics and cosmology.
Modern approaches for developing antivirals against SARS-CoV 2 (MAD-CoV 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Austria,Spain,Sweden,Sweden,France,United Kingdom
Call: Development of therapeutics and diagnostics combatting coronavirus infections (H2020-JTI-IMI2-2020-21-single-stage, 2020)
Start date: 2020-08-01
End date: 2024-07-31
Duration (months): 48.0
Total project cost (EUR): 6405168.75
EU funding (EUR): 3749668.75
Participants: 9
Project status: SIGNED

The SARS-CoV-2 pandemic has become an unprecedented burden to public health, our civil societies and the global economy. To provide frontline therapies for COVID-19 and future corona virus outbreaks requires a concerted effort of different disciplines, technologies, high security labs, and rapid translation of scientific findings to highly innovative and “hungry” SME partners. For the MAD-CoV-2 project we have assembled a multidisciplinary team of world-leading researchers and innovative industry partners to unlock the Achille’s heels of the virus infections in host cells and rapidly translate such knowledge into disruptive new medicines and public health measures. Our team members have been on the ground of the first SARS and Ebola outbreaks, head containment facilities to study highly infectious viruses, are world-leading in engineering human tissues, developed breakthrough technologies that allow us to find host factors for viral infections at unmatched speed and resolution, and discovered ACE2 and made the first in vivo link between ACE2, SARS, and lung injury, leading to rational drug development which is imminent to be tested in European COVID-19 patients. ACE2 is also the key receptor for SARS-CoV-2 Spike protein and has got centre stage for novel therapies and a fundamental understanding of COVID-19. The aims of MAD-CoV-2 are 1. to engineer human tissues to test novel therapies and vaccines; 2. to provide critical evidence on the role of clinical grade ACE2 in viral replication and COVID-19 pathogenesis; 3. to perform high-throughput screens to genetically map, at a single amino acid resolution, essential host factor that are critical for SARS-CoV-2 replication; and 4. to rapidly translate this knowledge into novel therapies to fight the current and, importantly, future corona virus outbreaks. Our data and unique tissue reagents will be made available to the entire community for drug testing and development, supporting all other efforts.

Keywords: covid 19,sars cov 2,haploid cells,3d organoid,ace 2