Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Making Complex Gas Analytics Friendly and Available ASAP (GasApp)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 149962.5
EU funding (EUR): 149962.0
Participants: 1
Project status: CLOSED

GasApp aims at bringing the capability to detect gases to every existing smartphone in just a few months. Carrying out a gas measurement will be as simple as taking a snapshot with the phone’s camera. Technically, we will rely on colorimetry methods to turn the presence of chemical substances into colour changes. GasApp wants to take a fast track towards accurate, highly specific, and highly accessible measurements by rethinking the concept of “ubiquitous sensing”. Instead of developing new complex electronic devices, our approach builds upon existing ubiquitous devices (i.e. smartphones), a new software App and inexpensive Tags based on knowledge produced in an ERC-funded project to achieve a user friendly gas-sensing product ASAP, and making business out of this opportunity. GasApp has the potential to impact on the 2.6 billion smartphones existing today. In the short-term, GasApp will be ready to satisfy existing customer needs in mature and well stablished markets, due to the readiness of the technologies involved, such as safety at work or at home, emissions control, personal healthcare, marketing, societal involvement, etc. In the midterm, being a part of the fertile ecosystem of the Internet of Things (IoT) will certainly foster the development of new uses of gas sensors, as occurred before with cameras, GPS, touch sensors, etc. In this PoC project, we will 1) implement the first App/Tag proof-of-concept prototype aimed at relevant gas sensing scenarios outdoors, and 2) define the exploitation strategy of this technology, including full a market survey, IPR positioning, business model, and fund raising. The proposal is implemented in a 18 months workplan and 2 work packages, devoted to develop the prototype and to define the exploitation strategy, in close interaction.

Keywords: sensors,internet of things,low cost,gas analysis
Engineering Bio-Inspired Systems for the Conversion of Solar Energy to Hydrogen (BioInspired_SolarH2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-09-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

With this proposal, I aim to achieve the efficient conversion of solar energy to hydrogen. The overall objective is to engineer bio-inspired systems able to convert solar energy into a separation of charges and to construct devices by coupling these systems to catalysts in order to drive sustainable and effective water oxidation and hydrogen production. The global energy crisis requires an urgent solution, we must replace fossil fuels for a renewable energy source: Solar energy. However, the efficient and inexpensive conversion and storage of solar energy into fuel remains a fundamental challenge. Currently, solar-energy conversion devices suffer from energy losses mainly caused by disorder in the materials used. The solution to this problem is to learn from nature. In photosynthesis, the photosystem II reaction centre (PSII RC) is a pigment-protein complex able to overcome disorder and convert solar photons into a separation of charges with near 100% efficiency. Crucially, the generated charges have enough potential to drive water oxidation and hydrogen production. Previously, I have investigated the charge separation process in the PSII RC by a collection of spectroscopic techniques, which allowed me to formulate the design principles of photosynthetic charge separation, where coherence plays a crucial role. Here I will put these knowledge into action to design efficient and robust chromophore-protein assemblies for the collection and conversion of solar energy, employ organic chemistry and synthetic biology tools to construct these well defined and fully controllable assemblies, and apply a complete set of spectroscopic methods to investigate these engineered systems. Following the approach Understand, Engineer, Implement, I will create a new generation of bio-inspired devices based on abundant and biodegradable materials that will drive the transformation of solar energy and water into hydrogen, an energy-rich molecule that can be stored and transported.

Keywords: electronic properties,molecular architecture,structure properties relations,coherence enhanced function
DEAD-box ATPases as master regulators of phase-separated compartments to control cellular RNA flux and the remodeling of RNA-protein complexes (DDX TRANSIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499845.0
EU funding (EUR): 1499845.0
Participants: 1
Project status: SIGNED

Life ultimately depends on the tight control of gene expression, which requires an ordered and efficient processing of various RNA molecules. Messenger RNAs (mRNAs) – bound by a constantly changing coat of passenger proteins - transit from transcription in the nucleus to translation and ultimately decay in the cytoplasm. Similarly, ribosomal rRNAs migrate through the nucleolus where they gradually en-counter ribosomal proteins to assemble functional ribosomes. Still, we know very little about the pro-cesses that orchestrate this flux of RNA in a temporal and spatial manner. Intriguingly, many RNA processing steps occur in membraneless organelles formed by liquid-liquid phase separation, e.g. nuclear speckles or the nucleolus, but the function of condensate formation in RNA processing is not known. I have discovered that the family of DEAD-box ATPases (DDXs) are master regulators of RNA-containing membraneless organelles, from bacteria to man. DDXs use their low-complexity domains and ATPase activity to regulate condensate dynamics and RNA flux through these compartments. I propose that cells use DDX-controlled condensate ‘stations’ to establish an RNA ‘transit map’ to reg-ulate the cellular flux of mRNA and rRNA molecules and to spatially and temporally control RNA pro-cessing. In three work packages, I will (1) characterize central DDXs that control mRNA flux and use DDX mutants as unique tools to map passenger protein changes along the life of an mRNA; (2) charac-terize how DDXs regulate the formation of the phase-separated nucleolar environment and facilitate the flux of rRNA during ribosome assembly; (3) dissect how DDX condensates function as biomolecular filters to selectively enrich or exclude proteins, and how selectivity contributes to the remodeling of the RNA protein coat and directional RNA flux. Our research will provide key novel insight into our understanding of RNA processing and uncover novel layers of gene expression regulation.

Keywords: dead box atpases,liquid liquid phase separation,membraneless organelles,mrna,rrna,rna protein complexes,rna flux
Evolution of multicellular life cycles (EVOLIFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Life cycles are central to all living organisms on Earth -- every living being is born, grows, and eventually reproduces. There is a great diversity of life cycles even among species we consider ``simple'': unicellular and primitive multicellular life forms. They reproduce in a number of ways: by fragmentation of the colony in multicellular pieces, by emission of unicellular propagules, and by dissolution of the organism into solitary cells. The choice of life cycle has a strong impact on the evolution of complex traits on the way to advanced multicellularity. But what drives the evolution of life cycles in the first place? The proposed research project will develop theoretical foundations for the evolution of multicellular life cycles. We will investigate the evolution of reproduction via a single-cell bottleneck (WP1), the impact of cell colony structure on the evolution of reproduction modes (WP2), the eco-evolutionary dynamics of multicellular life cycles (WP3), and generalise over previous findings to reveal the interplay of factors driving the evolution of multicellular life cycles (WP4). To do so, we will combine methods and insights from mathematics, physics, demography and classical biology. The proposed research program will cast light on the fundamental principles behind one of the most fascinating events in the history of life - the transition from simple solitary cells to complex multicellular existence. As such, the research results will be of interest not only to academics but also the general public. In addition, the Researcher will further enhance his knowledge and skills by working in an internationally renowned institution alongside experts in the field.

Keywords: evolutionary theory,emergence of multicellularity,life cycles evolution
Developing Fish Skin as a sustainable raw material for the fashion industry (FISHSkin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Iceland,Italy,Iceland,Italy,Israel,Italy,Switzerland,Japan,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 552000.0
EU funding (EUR): 552000.0
Participants: 12
Project status: SIGNED

The Fashion industry is currently going through a significant change in its approach towards sustainability, aiming to transform from a wasteful and polluting industry into the into a cleaner and more circular sector. In FISHSkin, our research concentrates on developing a new category of raw material for fashion – fish leather. we aim to amalgamate the Mariculture and Fashion industry by using both the fish flesh and skin as viable, economically useful products. While fish leather was used for centuries by indigenous people in Northern Europe and Asia, it was pushed aside by hides which offered better characteristics. Today, however, circular economy principles combined with state-of-the-art technology and changing consumer tastes – allow us to challenge existing fashion assumptions and explore the viability of fish leather is this industry. Through secondments and network training events we will generate knowledge cohesion from different disciplines: Fashion design, Material science and Marine biology where academic and industrial experts will strive to develop new techniques and methodologies for a market take up of fish leather at an industrial scale.

Keywords: fashion design,tanning,fish skin,sustainable fashion,design based materials,textile printing,surface treatment,circular economy,responsible sourcing,renewable raw materials
AUTOMATED DIAGNOSTICS AND RADIOLOGICAL READING FROM LUMBAR SPINE MRI (CoLumbo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Bulgaria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CoLumbo is an innovative AI online platform for diagnosing herniated disc and other spinal pathologies, capable of MRI reading, and medical history analysis. The innovation is based on fully convolutional neural networks (FCNN) for MRI reading, and uses a specially designed patent pending algorithm to compensate for a smaller number of training datasets without loss of accuracy or reliability.
Delivering next generation Transport Management System to European transport SMEs (INTRANSYS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Lithuania
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2016-04-01
End date: 2018-04-30
Duration (months): 25.0
Total project cost (EUR): 1706605.0
EU funding (EUR): 1194623.5
Participants: 1
Project status: CLOSED

State-of-the-art Transport Management Systems conceived in modular approaches do not provide an all-in-one solution to answer SME business-related needs more broadly. To own a holistic TMS requires a long and expensive integration and customization process which makes TMSs not affordable by SMEs who generally lack resources for it. Additionally, none of the current solutions are able to gather real time data to support real time optimization decisions. At Ruptela we are committed to developing a new, highly competitive and integrated platform providing all the necessary information to transport SMEs and representing an affordable solution for them: INTRANSYS. INTRANSYS will use our award-winning fleet tracking and management platform TrustTrack as a foundation to integrate continuously updated traffic data, tracking services, rich communication with driver and eco-driving tools into a single cloud-based application. This real-time integration will allow transport companies to optimize operations on the go 24/7. As we will offer the system as an “all-inclusive” solution, we will drastically reduce the customization and set-up process both in terms of time and costs. We will achieve this goals by providing a SaaS based pricing model adapted to SME size and usage. INTRANSYS’ ease of use, combined with our extremely competitive pricing strategy opens the door for the widespread commercial adoption by SME transport companies who dominates the European transport market. Note that we will allow massive savings on European transport SMEs (up to 19% of all transportation processes) while contributing to the EC’s goal of forcing the reduction of CO2 emissions of the transport industry.

Keywords: transport management system tms,fleet tracking,fleet management,eco driving,real time,route optimization,decision support tool,integrated tms,real time data gathering
From the understanding of KRAS-RAF membrane dynamics to new therapeutic strategies in cancer (KARMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1996853.0
EU funding (EUR): 1996853.0
Participants: 1
Project status: SIGNED

Cellular homeostasis is controlled by the RAS-MAPK pathway. This pathway is dysregulated in human diseases, especially cancer, in which more than 50% of cases carry aberrations that hyperactivate RAS-MAPK signaling. In this context, KRAS mutations are the most frequent oncogenic drivers. Therapeutic suppression of pathogenic KRAS-RAF-MAPK signaling to achieve disease control in cancer patients still represents a challenging target. KRAS dimers and multimers at the membrane (collectively referred, together with adaptors and effectors, as to “KRAS signalosome”) influence the activation of KRAS signaling. I provided the first biological evidence that dimerization is required for the function of oncogenic KRAS (Ambrogio et al, Cell, 2018). Indeed, one fascinating and still largely unexplored aspect of KRAS biology is the functional impact of KRAS complexes at the membrane for signaling and drug sensitivity. No inhibitors of oncogenic KRAS clustering have been identified so far. Interestingly, wild-type KRAS antagonizes oncogenic KRAS, resulting in reduced oncogenic signaling. The overarching goal of this proposal is the characterization in vitro and in vivo of the “KRAS signalosome” in terms of functional dynamics and related actionable vulnerabilities. My strong background in KRAS biology provides me with the expertise to propose an ambitious, yet feasible plan to understand the tumor suppressor effect of wild-type KRAS protomers in mutant KRAS-driven complexes by identifying and validating membrane interactors differentially recruited by wild-type and mutant KRAS (Work package 1). In parallel, I will study the relevance of RAF kinases localization at the membrane as key feature to sustain oncogenic MAPK activity in vivo (Work package 2). Finally, I will screen new compounds to interfere with RAFs function at the cell membrane and will determine the therapeutic impact of disrupting mutant KRAS signalosome using mouse models in vivo (Work package 3).

Keywords: kras oncogene,mapk signaling pathway,genetically engineered mouse models,kras dimerization,raf kinases,novel therapeutic approaches
Low-latency and private edge computing in random-access networks (LANTERN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

We are living in a world where connected devices outnumber human population, and this trend keeps growing: around 24.6 billion connections are forecasted in 2025—more than three times the estimated population. This gives rise to the Internet of Things (IoT) in which virtually all devices are interconnected and continuously share data. The IoT is a key enabler for a host of applications, such as intelligent transportation systems, smart cities, and smart grids. Thus it promises to transform the way we live. To realize the IoT, it is crucial and timely to develop a communication and computation infrastructure that is able to support the processing of a vast amount of time-sensitive data, for which a centralized computation is inadequate. Edge computing has emerged as a novel paradigm to guarantee very low-latency and high-bandwidth computing services. It involves moving the computation power from the cloud to where data is generated, by pooling the available resources at the network edge. In this project, we investigate how low-latency and private edge computing protocols can be developed in wireless random-access networks. Relying on tools from information theory and coding theory, we will tackle the two following challenging objectives: i) to establish a foundation for privacy and reliability in latency-critical, multi-client and multi-server edge computing in random-access networks; and ii) to devise resilient coding schemes together with energy-efficient and scalable wireless random-access protocols to achieve low latency and preserve privacy in distributed edge computing. The results of this project will help paving the way to the full realization of the IoT in the near future.

Keywords: internet of things,edge computing,computation,latency,privacy,random access networks,wireless communications,information theory,coding theory
Integration of PEF in food processing for improving food quality, safety and competitiveness (FieldFOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Germany,Ireland,Spain,Italy,Germany,Ireland,Netherlands,Denmark,Portugal
Call: Innovative solutions for sustainable novel food processing (H2020-SFS-2014-2, 2014)
Start date: 2015-04-01
End date: 2018-03-31
Duration (months): 36.0
Total project cost (EUR): 2242660.0
EU funding (EUR): 1994301.25
Participants: 13
Project status: CLOSED

Pulsed electric field technology (PEF) represents an innovative solution for sustainable processing in order to improve the competitiveness of the European food industry. Currently, in spite of the many advantages deriving from the introduction of the PEF technology in the food industry and the existence of different PEF manufactures at industrial-scale, applications of PEF in the food industry is still limited. FieldFOOD project is based on a preliminary analysis addressed to identify the bottlenecks that cause such limited application with the objective of providing SME companies (food producers, pulse power producers, equipment manufactures) with a clear competitive edge, as well as opportunities for growing, diversification and job creation but also of responding to consumer demand for foods with fresh characteristics or novel foods that contribute to individual health and wellbeing. This broad objective will be achieved by: a) a systematic process analysis of different specific applications (fruit juice processing, tomato product processing, winemaking, olive oil extraction and cider-making) for a successful integration of the PEF technology in order to replace or complement existing traditional food processing technologies and b) the design of modular, portable, low-cost pulse generators. The main deliverable of FieldFOOD project will be to validate and demonstrate, in co-operation with SMEs, implementation of modular, portable, low-cost pulse generators for different applications. The efforts needed to introduce this technology in the food industry for different applications are necessary to be multidisciplinary. Therefore, to be efficient and successful, strong links needs to be established between research institutions with a well-established expertise in PEF technology (4 partners), manufactures of PEF generator (1 SME partner) and food companies (5 SMEs partners) that represent the final users of the technology.

Keywords: pulsed electric fields