Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First application and market introduction of combined wastewater treatment and reuse technology for agricultural purposes (RichWater)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Spain,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-02-01
End date: 2018-10-31
Duration (months): 33.0
Total project cost (EUR): 2083866.2
EU funding (EUR): 1658703.13
Participants: 6
Project status: CLOSED

In recent years, a growing concern has been expressed throughout the EU regarding water scarcity problems and the significant impacts on freshwater resources by agricultural activities. The concept presented in this project is an advancement of the TREAT&USE system, a successful EU research project (FP7) approaching the safe reuse of wastewater in agriculture production with excellent technical and scientific results. The upscale of TREAT&USE prototype will permit to overcome main barriers to reach the market and adapt the technology to intensive agriculture production. The result will be a commercial system thoroughly demonstrated and tested in its operational environment. RichWater system is composed of a low-cost and energy-efficient MBR (to produce pathogen-free and nutrient rich irrigation water), a mixing module (for tailor-made mixing with freshwater and additional fertilizers), the fertigation unit and a monitoring / control module including soil sensors to guarantee demand-driven and case sensitive fertigation. By combining these developed modules a complete and turn-key system for safe wastewater reuse in agriculture is available covering all topics relevant to farmers and the market. In TREAT&USE, a prototype system has already been tested and implemented in a small-scale tomato plantation in Southern Spain. It is RichWater project ambition to develop an up-scaled commercial prototype (min. 100 m³ treatment capacity/day) and pursue the goal of implementing it in a real scale food producer in Southern Spain to reuse local community wastewater for irrigation purposes. The aim is to create a win-win situation between two sectors (the wastewater treatment and the agricultural sector) by turning public wastewater into a valuable end-product. A detailed life cycle assessment and business plan will help to precisely assess the ecologic, technological and economic benefits enabling an effective market strategy.

Keywords: water reuse,reclaimed water,sustainable agriculture,water management,smart irrigation
Enhanced Qualitative and Multi-Method Research in Political Science (ENHANCEDQMMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1125575.0
EU funding (EUR): 940262.5
Participants: 2
Project status: CLOSED

Over the last 20 years, qualitative methods in political science have developed rapidly on three dimen-sions. First, set theory was formulated as an alternative to what is called the quantitative worldview. Second, process tracing for the analysis of mechanisms evolved as a complement to the estimation of marginal effects. Process tracing has also been tied to Bayesianism as opposed to frequentism. Third, process tracing became an element of multi-method research (MMR), integrating it with frequentist statistics or Qualitative Comparative Analysis (QCA). An important element of the development of qualitative methods is its contrast with quantitative methods. At the same time, quantitative researchers critically commented on that development. The constant exchange has contributed to the progress of qualitative methods, but the debate has reached an impasse in some respects, or has pursued one line of development while neglecting others. Building on state-of-the-art qualitative methods, ENHANCEDQMMR seeks to overcome this impasse and to explore new ground.It makes four significant contributions to the progress of standalone qualitative methods and as part of MMR. First, it examines experimentally how researchers decide between a set-relational and correlational view on causation and whether they can realize designs in accord with their initial decision. Second, it develops tools for sensitivity analyses, diagnostics, and the modeling of diverse data structures via QCA for strengthening QCA-based inference. Third, it com-pares the performance of QCA and regression analyses under simulated data-generating processes with the goal of generating comparative diagnostics, possibly allowing one to adjudicate between both methods in observational research. Fourth, it formulates standards for Bayesian MMR by combining Bayesian process tracing with Bayesian statistics and Bayesian QCA, respectively. The insights of the project will be implemented in freely available software.

Keywords: alphabetically case studies,causal inference,multi method designs,nested analysis,political science methods,process tracing,qualitative comparative analysis qca,research design,set theory
miRNA biomarkers of Osseous Metastases in Serum from breast cancer patients (miROMeS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-09-20
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.

Keywords: mirna,biomarker,serum,exosomes,bone metastasis,breast cancer,metastasis
Development of an Intelligent Onshore Pipeline Integrity Monitoring System (iPIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Greece,United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2014, 2014)
Start date: 2015-10-01
End date: 2018-03-31
Duration (months): 30.0
Total project cost (EUR): 1343975.5
EU funding (EUR): 940782.0
Participants: 2
Project status: CLOSED

In iPIM a developed prototype of sophisticated non-destructive technique (NDT) for structural health monitoring system (SHM) of oil and gas (O&G) pipelines will be further modified so that the system can be made available for commercialization. iPIM will continuously monitor the pipeline for cracks, corrosion and other faults and send the information over a wireless communication system to the network monitoring centre where the fault will be displayed over a 3D map of the pipeline. This will help the pipeline operators to take preventive and corrective measures before any accident stemmed from pipeline failure occurs. A low profile wireless Acoustic Emission (AE) and Long Range Ultrasonic (LRU) dual mode sensors will be permanently attached on the pipeline with a collar installed 100m apart from each other that can monitor 50m of pipeline in either side. The sensors will act in passive AE mode in normal operation and on detection of an anomaly will switch to LRU mode to locate and determine the characteristics of the anomaly. An artificial neural network (ANN) and data fusion system will intelligently manage data acquisition and analysis functions based on data received from the installed sensor nodes. An energy harvesting system will be developed to power the onsite electronics. A new software will be developed that will enable advanced signal processing with improved signal/noise separation in handling sensor data, thus supporting more sensitive measurement and more effective analysis. iPIM will ensure onshore pipeline safety and reduce cost due to pipeline failure in the Europe. The expected profit to the SMEs generated through the exploitation of the iPIM system is in the order of €56 Million, representing a return on investment (RoI) of 612%. With revenue per capita in the sector of €100,000 per employee, the creation of some 600 new, high-skilled, high-technology jobs in Europe has been anticipated.

Keywords: ndt non destructive testing,shm structural health monitoring,lru long range ultrasonic,oil and gas,pipelines
Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs (InterTAU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Argentina,Indonesia,Austria,Slovakia,Latvia,Czechia,United States,Canada
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1058000.0
EU funding (EUR): 1058000.0
Participants: 13
Project status: SIGNED

There is an enormous and unmet medical need to find efficient methods of prevention, diagnosis and disease- modifying therapies for neurodegenerative disorders, including Alzheimer’s disease (AD), other tauopathies and Parkinson’s disease (PD). The common molecular denominator of tauopathies are pathological forms of tau protein, and in Parkinson’s disease these are pathological forms of -synuclein. Moreover, -synuclein has a distinct role in pathophysiology of tauopathies, mainly in tau hyperphosphorylation and aggregation, and vice versa. Tau pathology relates to conformational changes during oligomerization and assembly resulting in toxicity. Given their role in the pathogenesis, conformationally altered and assembled tau or -synuclein would be a promising molecular target for disease-modifying therapies. However, the field is still lacking a deeper understanding of associated structural changes in the course of assembly and their inducers on the pathway towards pathological forms of these proteins; therefore, the pharma development is hampered. The main aim of the InterTau project is the detailed structural and biophysical characterization of tau and -synuclein -synuclein protein and their variants in monomeric, oligomeric and fibrillar states relevant for AD, other tauopathies. The InterTAU consortium is composed and academic partners with cutting- edge methodologies suitable for functional and structural characterization of the tau assembly pathway by solution and solid-state nuclear magnetic resonance (NMR), cryo-electron microscopy and cellular assays corroborated by bioinformatics. The mutual transfer of complementary expertise envisaged in the project will facilitate academic outcome and biotechnological development. Specific expertise will be transferred from three institutions in North America and one institution from Argentina. The results of InterTAU will be directly translated into innovation in biotech through the non-academic partner. The platform for sharing knowledge will be a foundation of sustainable cooperation beyond the InterTau project.

Keywords: solid state nmr,solution nmr,cryo em,protein protein interactions,immunology,tauopathies
Feasibility of Salmon and Kingfish Land-Based Aquaculture Systems, Phase 1 (SAKLAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Norway
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SAKLAS will mature and validate a disruptive, cost-effective, and 100% sustainable Recirculating Aquaculture System [RAS] concept for farming two high-value fish species, Atlantic Salmon [AS] and Yellowtail Kingfish [YK], solving critical production problems related to current RAS-based farming methods. SAKLAS is a major operational and technical advance in the EU, offering reductions in investment and operational costs of 20-50% and 15% (respectively) higher and stable biomass densities (60-90 kg/m3) with lower mortality rates (8%) and reduced environmental impact (e.g. phosphorous release is minimized to 1.5 mg in 100 m3/h outlet water flow). These numbers make SAKLAS the unbeatable and first profitable RAS solution for AS and YK grow-out worldwide, opening doors for farming warm water fish species (such as YK) in northern latitudes for the first time. We estimate that by the end of 2023 (5 years after project completion) we will have reached an accumulated revenue and profits of €95.6m and €26.3m, and generated at least 18 new full time employments [FTE]. At this state, a Phase 1 grant is sought to verify SAKLAS market potential, as well as its technical and economic viability. The main activities of our Feasibility Study are: - To elaborate a market, competitor and IPR analysis. - To perform cost assessment for optimal positioning of our products (AS and YK) in the market. - To establish the requirements (technical, legal, etc.) for final the integration and testing of SAKLAS in a real operational environment, and to formulate a Project Execution Plan for implementation of the envisaged Phase 2 project. - To evaluate investment requirements post Phase 2 project, secure financing sources, and develop a detailed Business Plan.

Keywords: recirculating aquaculture systems,atlantic salmon,yellowtail kingfish,sustainable aquaculture,fish health,water quality,product quality
Wind Turbine Shearography Robotic Inspection On-blade System (SheaRIOS) (SheaRIOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Spain,Greece,Greece,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Advanced robot capabilities research and take-up (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-03-31
Duration (months): 51.0
Total project cost (EUR): 3242788.61
EU funding (EUR): 2716906.62
Participants: 11
Project status: CLOSED

SheaRIOS is a solution for the Wind Turbine Blade (WTB) inspection industry that enables easier, faster and more accurate inspection utilising robotics and shearography, a high-quality method that is applied outside of the laboratory for the first time. A deployment platform will ascend on the wind turbine tower and deploy a work climber on the base of the blade. The climber will move on the blade by means of air-suction and carry out inspection with a shearography kit on a cantilever. The deployment platform will also act as the power and data link. Operational modelling is done by EDF, the end-user that drives this Innovation Action. Preliminary testing and validation of the market-readiness of the SheaRIOS robotic application will take place at their on-shore wind turbine facilities. Three competitive small and mid-scale technology companies from three European countries will contribute so Europe will (1) integrate more wind power, (2) reduce operational costs, (3) keep the technology lead, and (4) remain a major export. As per Wind Europe, these are the targets for enabling wind to become the backbone of our electricity generation system. Based on our analysis, the non-destructive testing service provider would save 1,055€ per wind turbine inspection and payback of SheaRIOS investment will be achieved after 152 inspections, or the first 2 years. The wind farm operator will save more than 1 full day per wind turbine inspection, because of the reduced inspection time, which directly translates to less revenue lost due to idle wind turbines. Finally, the cumulative savings for a period of the first 5 years will translate to €92.74m, assuming SheaRIOS will be successful in averting just 20% of the unforeseen WTB failures and contributing to increased health and safety for the rope access workers that are involved in hundreds of accidents each year. [1] Wind Europe, “Making transition work”, September 2016

Keywords: renewables,wind,turbines blade inspection,shearography,robotics,crawler,renewable energy
Lab-on-a-chip microfluidic device based on plasmonicdriven thermal sensing for rapid detection of Salmonella typhimurium in agro-food field. (HEATSENS_S)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NANOIMMUNOTECH (NIT), a leading company in nanobiotechnology with know-how that has been applied to the field of nanobiosensing and especially the agro-food sector introduces HEATSENS in the poultry industry: a solution that transforms into a portable and easy-to-use device with its most cutting-edge know-how in biosensors. HEATSENS is based on a revolutionary nanobiosensing technology owned by the company, whose main characteristics (highly sensitive, rapid detection and simplicity) are the ideal response to a clear need in this sector to test for Salmonella. Salmonella is the second most commonly reported gastrointestinal infection, requiring hospitalisation in many cases, and it can be fatal. One of the most common ways of contracting it is by eating contaminated chicken meat; thus meat companies are required to carry out periodic tests, for which they send samples to specialist laboratories that have a response time of up to 7 days for the analyses, which may mean financial losses. Given that this technology fits into the NIT development strategy, it was decided to perform proofs of concept with several companies in the sector, which clearly showed that HEATSENS_S detects Salmonella at a higher sensitivity in only 3 hours. In light of these results, these potential customers have already shown their keen interest in HEATSENS_S. Now, its conversion into an easy-to-use portable device makes performing in-house testing possible throughout the production chain, providing companies with greater control over product quality and avoiding losses associated with contamination not detected in time, all at a lower cost than current tests today. NIT Management considers this to be the optimum catalyst for the growth of the company and its expansion worldwide and HEATSENS, the flagship product, to make their efforts profitable in nanobiosensing.

Keywords: nanobiosensing,salmonella,rapid detection,ultrafast high sensitivity
Decoding planetary compositions using observations and modelling of planet-forming disks (DISCO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-03
End date: 2019-07-02
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Our sun is host to eight planets, and recent discoveries have revealed that there is at least one planet per star in the Galaxy. Moreover, small, rocky planets like the Earth outnumber the Jupiter-like gas giants. The bulk elemental composition of most planets is not yet known, but evidence from the solar system and some extrasolar (proto-)planetary systems suggests there are considerable variations in the abundance of elements such as carbon, chlorine, iron and others. Some of these variations are seen in the rocky planets, others apply to atmospheres of giant planets. Understanding this diversity is important, as the Earth's elemental budget is key to various aspects of its habitability. Therefore, we must understand the origin of planetary compositions if we are to scientifically estimate the number of habitable worlds. In the DISCO project, I will study the elemental abundances in the inner and outer regions of planet-forming disks around young stars and will build models to capture the main processes that affect the gas-ice-refractory balance of specific elements. These analytical models will be implemented in a chemically-based planet population synthesis calculation which can be compared with known planetary compositions and will allow to predict the distribution of elemental compositions of exoplanets.

Keywords: sub millimetre astronomy,astrochemistry