Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vascular Engineering on chip using differentiated Stem Cells (VESCEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: CLOSED

Organs-on-chip hold great promise for the creation of complex and realistic disease models while having the potential to refine, reduce and (partly) replace existing animal models (3R principle). Of all organs, vasculature is extremely well-suited to realize on-chip since it pervades the whole organism, is present in all other organs, its malfunctioning plays a role in many diseases and finally is ideally suited to approach with microfabrication and microfluidic technologies. In the VESCEL program we propose the development of innovative technologies enabling the use of differentiated human induced pluripotent stem cells (hiPSC) to engineer blood vessels on chip that constitute realistic disease models for thrombosis and neurodegenerative (ND) diseases. The use of differentiated hiPSC allows the realization of blood vessels based upon patient-specific material, without the need for biopsies, while development of integrated microsensors for small molecules (pH, O2, NO) offers the possibility of on-line monitoring. To optimize the hiPSC differentiation conditions we propose the use of a microdroplet platform, that combines high-throughput capability (up to 1000 cells/s) with control of single cell microenvironment. We will also develop a new flexible technology for real 3D vasculature realization using advanced 3D printing technologies. These four innovative technology developments will be integrated in two biomedical applications to study two important classes of diseases, thrombosis and neurodegenerative (ND) diseases. For thrombosis we focus on the study of parameters such as blood pressure and stenosis as well as effects of drugs on thrombus formation, while for ND diseases study we will use a blood brain barrier (BBB) model to investigate nanoparticle and peptide transport across the BBB for a form of Alzheimer’s disease, as well as leukocyte extravasation for multiple sclerosis (MS).

Keywords: organ on chip,microfluidics,droplet microfluidics,sensing
Foundations for Fair Social Computing (FairSocialComputing)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2023-06-30
Duration (months): 60.0
Total project cost (EUR): 2487500.0
EU funding (EUR): 2487500.0
Participants: 1
Project status: SIGNED

Social computing represents a societal-scale symbiosis of humans and computational systems, where humans interact via and with computers, actively providing inputs to influence and being influenced by, the outputs of the computations. Recently, several concerns have been raised about the unfairness of social computations pervading our lives ranging from the potential for discrimination in machine learning based predictive analytics and implicit biases in online search and recommendations to their general lack of transparency on what sensitive data about users they use or how they use them. In this proposal, I propose ten fairness principles for social computations. They span across all three main categories of organizational justice, including distributive (fairness of the outcomes or ends of computations), procedural (fairness of the process or means of computations), and informational fairness (transparency of the outcomes and process of computations) and they cover a variety of unfairness perceptions about social computations. I describe the fundamental and novel technical challenges that arise when applying these principles to social computations. These challenges are related to operationalization (measurement), synthesis and analysis of fairness in computations. Tackling these requires applying methodologies from a number of sub-areas within CS, including learning, datamining, IR, game-theory, privacy, and distributed systems. I discuss our recent breakthroughs in tackling some of these challenges, particularly our idea of fairness constraints, a flexible mechanism that allows us to constrain learning models to synthesize fair computations that are non-discriminatory, the first of our ten principles. I outline our plans to build upon our results to tackle the challenges that arise from the other nine fairness principles. Successful execution of the proposal will provide the foundations for fair social computing in the future.

Keywords: social computing,computational social science,fairness,accountability,and transparency in ml
Unraveling the role of anisotropy in material failure (QUANTIFY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel,Spain,Poland,France,United States
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 153000.0
EU funding (EUR): 153000.0
Participants: 8
Project status: SIGNED

The overall objective of the QUANTIFY action is to form an international network of 8 organisations, working on a joint research programme in the field of Solid Mechanics. The 8 organisations (4 European beneficiaries and 4 US partner organisations) will exchange and share skills and knowledge with the view to understand and model the effect of anisotropy in the dynamic mechanical failure of lightweight metallic materials used in the transportation and civilian-security industries. Breakthroughs in this field will allow lightweight metals fabricated with microstructure optimization techniques and additive manufacturing to replace steel and heavy alloys in manufacturing high structural responsibility components for automobiles, ships, aircrafts and civil infrastructures, all sectors of crucial importance for the European economy and society. The staff members who participate in the project will be exposed to new research environments and develop new skills, thus contributing to their increased employability and supporting research in Europe. The 8 organisations will further strengthen their knowledge base, and (further) develop lasting collaborations.

Keywords: solid mechanics,lightweight alloys,mechanical anisotropy,mechanical failure,modelling
Earth-like Planet Imaging with Cognitive computing (EPIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Belgium,Sweden
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2025-04-30
Duration (months): 72.0
Total project cost (EUR): 2178125.0
EU funding (EUR): 2078125.0
Participants: 2
Project status: SIGNED

One of the most ambitious goals of modern astrophysics is to characterise the physical and chemical properties of rocky planets orbiting in the habitable zone of nearby Sun-like stars. Although the observation of planetary transits could in a few limited cases be used to reach such a goal, it is widely recognised that only direct imaging techniques will enable such a feat on a statistically significant sample of planetary systems. Direct imaging of Earth-like exoplanets is however a formidable challenge due to the huge contrast and minute angular separation between such planets and their host star. The proposed EPIC project aims to enable the direct detection and characterisation of terrestrial planets located in the habitable zone of nearby stars using ground-based high-contrast imaging in the thermal infrared domain. To reach that ambitious goal, the project will focus on two main research directions: (i) the development and implementation of high-contrast imaging techniques and technologies addressing the smallest possible angular separations from bright, nearby stars, and (ii) the adaptation of state-of-the-art machine learning techniques to the problem of image processing in high-contrast imaging. While the ultimate goal of this research can likely only be reached with the advent of giant telescopes such as the Extremely Large Telescope (ELT) around 2025, the EPIC project will lay the stepping stones towards that goal and produce several high-impact results along the way, e.g. by re-assessing the occurrence rate of giant planets in direct imaging surveys at the most relevant angular separations (i.e., close to the snow line), by conducting the deepest high-contrast imaging search for rocky planets in the alpha Centauri system, by preparing the scientific exploitation of the ELT, and by providing the first open-source high-contrast image processing toolbox relying on supervised machine learning techniques.

Keywords: exoplanets,high contrast imaging,image processing,deep learning,stellar coronagraphy,wavefront control,infrared instrumentation
Tracking our ancestors across the Devonian world: a new multidisciplinary approach to the origin of tetrapods (Tetrapod Origin)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Sweden
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2450143.0
EU funding (EUR): 2450143.0
Participants: 1
Project status: SIGNED

The origin of tetrapods (land vertebrates) during the Devonian period, a key event for the terrestrial ecosystem, is illuminated by splendid fossil discoveries but very ill-served by the dominant theoretical framework. This framework has two weaknesses: the persistence of a simplistic evolutionary scenario that has already been falsified, and a failure to properly consider the place of tetrapods in the developing terrestrial ecosystem. The scenario envisages tetrapods evolving from ‘elpistostegids’ like Tiktaalik in an aquatic environment during the Late Devonian, but fails to account for the existence of tetrapod trackways that are older than the elpistostegids, and cannot explain the evolution of structures such as a sacrum (link between pelvis and vertebral column) that lack inherent value for aquatic locomotion. The extraordinary value of the trackways as behavioural records of living animals is ignored. Environmental contexts like ‘flooded forests’ are proposed for the evolution of tetrapods without analysis of the environments where their tracks are preserved. Unless this situation is remedied the subject cannot progress. To solve these problems, I will combine my world-leading expertise on Devonian tetrapods with the skills of a team of world-class experts on trace fossils, morphometrics, geochemistry, sedimentology, Devonian land plants, and synchrotron tomography. This approach is unprecedented in the study of the origin of tetrapods. We will undertake a bold fieldwork program, coupled with cutting-edge, high-precision, multidisciplinary analysis, which will power the first-ever analysis of the fish-tetrapod transition in a fully elaborated environmental and ecological context. This will at last allow us to fully integrate tetrapods into the vibrant research area of terrestrial ecosystem evolution. We will also search systematically for the still-missing holy grail of early tetrapod research: body fossils contemporary with the earliest tetrapod trackways.

Keywords: ecosystem reconstruction
European food chain supply to reduce GHG emissions by 2050 (ENOUGH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Austria,Italy,Italy,Italy,Norway,Belgium,Lithuania,Poland,Norway,Türkiye,Hungary,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Testing and demonstrating systemic innovations in support of the Farm-to-Fork Strategy (H2020-LC-GD-2020-4, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 11692895.65
EU funding (EUR): 11022995.27
Participants: 31
Project status: SIGNED

The ENOUGH project will provide technologies, tools and methods to contribute to the EU Farm to Fork strategy to achieve climate neutral food businesses. The ENOUGH objectives are: i) Reducing GHG-emissions by at least 50% by 2050 ii) Reducing energy use and increasing energy efficiency by 2030. iii) Increasing the overall sustainability of food systems iv) Providing selected innovative technological systemic solutions and their potential for uptake at EU. The project brings together 30 partners from 9 EU nations, Norway, Turkey and the UK, who have in depth expertise across the whole food chain (refrigeration, cooking, baking, drying). The ENOUGH project is constructed around 11 work packages (WP): WP1 will identify 1990 and 2020 baselines for GHG emissions and will then forecast how emissions will change moving forward to 2030 and 2050. In WP2, we will identify what are the energy efficient measures and new technologies that are vital to achieve the maximum reductions in emissions. In WP4 we will use all the information and models from WP1 and 2 to develop a web-based tool that will identify the benefits of thermal integration heating and cooling and provide information on potential global emission reductions across the whole food chain. In WP5, data from food process and the food supply chain will be used to optimize and better control operations and technologies to minimize emissions. In WP3 and 7 we will examine how social behaviour, policy and finance can add to the GHG reductions target. In WP6, the more relevant and promising technologies will be demonstrated. A set of the most promising technologies TRL (5-7) have been pre-selected for demonstration based on their relevance and readiness. Additional technologies/operational adaptations will be added during the project and will be selected using a robust process managed by the coordinator and demonstrated in real life. Work from the ENOUGH project will be widely disseminated with an ambitious communication plan in WP8. WP9 includes all project management. WP10 oversees the ethics compliance of the project and WP11 includes communication with European Commission.

Keywords: thermal processes,refrigeration,energy use,ghg emissions,food transport,food storage,retail
ALBATROSS: The most energy efficient flying bird (ALBATROSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Switzerland,Sweden,Sweden,Belgium,France,France,France,France,Czechia,Netherlands,United States,United Kingdom
Call: Environmental sustainability (H2020-SESAR-2020-1, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 6940247.86
EU funding (EUR): 3996330.63
Participants: 20
Project status: SIGNED

Mobility and transportation are at the heart of our society which facilitate access to jobs, goods and services. And because air travel is one of the fastest and most progressive branches of the transportation sector it is also exposed to large visibility and strong European and worldwide pressure on sustainability. ALBATROSS is a wide scale initiative of major European aviation stakeholder groups to demonstrate how the technical and operational R&D achievements of the past years can transform the current fuel intensive aviation to an environment-friendly industry sector. To reach this goal ALBATROSS follows a holistic approach by covering all flight phases, directly involving all relevant stakeholder groups (such as Airlines, ANSPs, Network Manager, Airports and Industries) and addressing both operational and technological aspects of aviation and Air Traffic Management (ATM). The project will demonstrate the complementary of some solutions, from alternative aircraft fuel to enhanced ATM and Airspace Users operations on the ground, TMA and en-route. To foster increased flexibility and scalability the demonstrated approaches will also leverage cutting-edge technologies, such modern as air-ground connectivity means, and novel highly collaborative ATM procedures. The possibilities of implementing a “Flight with Zero waste of Fuel and CO2 emissions” will be explored and extensively demonstrated in real conditions, through a series of live trials in various European operating environments. The demonstrations will span through a period of several months and will utilize over 1000 demonstration flights, which will be supported by Air France, Novair, Lufthansa, Wizz Air and Swiss on Airbus and Boeing aircraft, 2 Airports and major ANSPs. During this effort a strong pressure will be put on objective measurability and representativeness of the results, built on systematic data collection, utilizing Big Data Analytics, Machine Learning and Artificial Intelligence.

Keywords: green flight,green trajectory,flight efficiency,co2 emission reduction,sustainable aviation
Point-of-care instrument for diagnosis and image-guided intervention of Colo-Rectal Cancer (PROSCOPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Austria,Germany,Germany,Germany,Germany,Ireland,United Kingdom,United Kingdom,Denmark
Call: Application driven Photonics components (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 5999383.75
EU funding (EUR): 5999383.75
Participants: 11
Project status: SIGNED

Colorectal cancer (CRC) is the second most common cause of cancer death in Europe, yet survival rates rise dramatically when caught early. A contributing factor is that current colonoscopy, i.e., white light video or optical narrow band imaging, is inadequate for in-vivo detection and characterisation of the various types of (pre-)cancerous lesions found in the colon. Point-of-care, real-time polyp diagnosis and image guided intervention has the potential to save huge healthcare costs by enabling early onset of treatment; thus reduced recurrence rate, by improving interval screening, and by reducing pathology costs incurred during colonoscopy. A complete, reliable optical diagnosis is sensitive to morphological and biochemical changes. Unfortunately, no single optical method provides both. PROSCOPE provides unique combination of label-free, non-ionizing, proven optical imaging modalities that provides higher sensitivity and specificity compared to current colonoscopy thus enabling a step-change in point-of-care management of CRC. PROSCOPE develops and integrates recent advances in optical imaging and optical probe technology into one platform. The concept is validated in clinical settings using existing endoscopes providing minimally invasive optical imaging that fits into current clinical procedures. A leading medical device manufacturer and clinicians are involved at every stage of the development and validation. PROSCOPE is driven by unmet clinical needs in the field of gastroenterological diagnosis with a clear business case: Combination of optical imaging techniques offers the potential to vastly improve early diagnosis of CRC achieving specificity and sensitivity above 90%, reducing the number of excisional biopsies by 50%, and improving interval screening planning, thereby reducing healthcare costs drastically and benefitting patients. The consortium includes five leading academics, including hospital clinics, and four SMEs covering the entire value chain.

Keywords: multimodal optical imaging,optical coherence tomography,raman spectroscopy,two photon light sheet microscopy,colo rectal cancer,gastroenterology,endoscopy,colonoscopy
Exploring the Terascale at LHC with Novel Highly Granular Calorimeters (Novel Calorimetry)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2022-03-31
Duration (months): 78.0
Total project cost (EUR): 3034107.0
EU funding (EUR): 3034107.0
Participants: 1
Project status: SIGNED

The recent discovery of a Higgs boson by the ATLAS and CMS Collaborations at the Large Hadron Collider at CERN, Geneva, has undoubtedly opened a portal to widely expected new physics, anticipated to manifest itself in the Tera-electron-Volt range: the Terascale. New physics is needed to understand some of the deepest mysteries of our universe, that include its composition, where dark matter and dark energy seem to comprise 95% of its energy/matter density, and its evolution from the Big Bang to today, where we see much structure and where matter dominates over antimatter, and whether we live in more dimensions than the familiar four. Substantial improvements to the current experiments at the LHC are planned, and new experiments are being proposed or discussed at future new energy frontier accelerators to tackle these scientific issues. A key element of the improved and newer generation detectors is the use of very high performance calorimeters for the measurement of the energies of particles produced in the high-energy collisions at colliders. At the upgraded LHC these must operate in an unprecedentedly challenging experimental environment. This proposal deals with a novel, yet untested, high-risk approach to calorimetry that combines state of the art techniques so far only used independently either in charged particle tracking or conventional calorimeters. New technologies will have to be developed for such a ground-breaking calorimeter. These include very fine feature size, powerful, radiation hard electronics in emerging technologies using feature sizes of 130 nm or 65 nm; low-cost silicon sensors in the emerging technology using 8” silicon wafers, also in Europe; environmentally-friendly cooling technologies using liquid carbondioxide; high performance and fast decision making logic using new more powerful FPGA, all to be produced at an industrial scale.

Keywords: lhc cms calorimetry