Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Representing Evolution (REVOLT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1592522.0
EU funding (EUR): 1592522.0
Participants: 1
Project status: SIGNED

A central part of scientific enquiry involves constructing representations of the world. Representations can take many forms, including diagrams, taxonomies, verbal descriptions, physical models, and abstract mathematical models. Thus a diagram of the solar system, a taxonomy of Alpine flora, a ball-and-stick model of a chemical substance, and a mathematical model of the spread of a disease are all examples of representations. Different though they are, each of these scientific constructs aims to represent some system in the world (the “target system”) and can be assessed for how well they achieve this aim. The aim of my project is to examine how biological evolution has been represented – diagrammatically, verbally and mathematically – in the scientific literature, past and present. A further aim is to examine representations of evolution in the context of pedagogy and science communication. “Biological evolution” is taken to include the process of descent with modification that Darwin first described; the mechanisms that drive the evolutionary process such as natural selection; and the products to which the process has given rise, such as adaptation and diversity. Scientists have constructed representations of each of these elements in their quest to understand how evolution works. My project will offer a systematic study of these representations from an overarching philosophical perspective. The importance of the project lies in its integrative ambition. The project will bring together philosophical ideas about the nature of representation and idealization, linguistic ideas about metaphor and analogy, psychological ideas about reasoning and cognitive biases, and educational ideas about science communication. By drawing on such a diverse range of ideas, the project will deepen our understanding of how evolution is, has been, and should be represented. The results will of interest to both philosophers of science and scientific practitioners.
Development of mesosphere in-situ measurement tools: Atmosphere Analyser (DAA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Portugal
Call: SME Instrument (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Mesosphere and Lower Thermosphere (MLT) are the most poorly known stages of the Earth’s atmosphere. Knowledge of the events on the MLT region are linked to better prediction of events on surface weather and thus improve weather forecasting, reduce insurance costs via better data and predictions, deliver fresh data for climate disasters prevention D-Orbit Atmosphere Analyser (DAA) is an innovative system based on nanosatellite technology that promises to deliver insitu real-time data on any geographical area of the MLT. DAA exploits recent advancement in space technology to provide services for Earth entities and commercial businesses. Our goal is to provide to commercial businesses and research entities fast, low cost, reliable and “fresh” data related to our planet, its atmosphere and the near space environment, via innovative systems independent from geographical locations and launchers’ cost. DAA offers real-time, geo-localized and fresh MLT data for catastrophe prevention and especially for insurance companies, improving their forecasts reliability, reducing their financial risk and thus increasing their margin on insurance products sold. DAA is scalable and easily upgradable to extend the sensors capabilities and thus enter in different “big data” market. This project will contribute to the generation of Climate Data Records being a support feature to efforts undertaken by ESA under the LEIT Space programme. Furthermore, DAA is a disruptive and competitive solution that will seize European and global business opportunities by transferring this advanced and low cost technology from the space industry to non-space areas.

Keywords: mesosphere,lower thermosphere,space,big data,nanosatellite,atmospheric data,real time,geo localized data
Protecting consumer and industrial products against counterfeiting with unforgeable nanoscale security elements (Morphotonix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Counterfeiting is a major global problem that affects virtually all industries. Globalization, lowering of trade barriers & improvements in technology have created attractive opportunities for counterfeiters to manufacture, distribute & sell fake products worldwide. Shrewd counterfeiters attempt to fake both the packaging of the products & products themselves. To prevent them from succeeding, product manufacturers are constantly looking for new copy- & tamper-proof security solutions for their products, which boosts the market. Only the hologram protection market (one of the most-widely used security products) was €16bn+ in 2015. The market is in dire need of a solution that will be able to make counterfeiting so expensive that it will no longer be economically viable. Our technology produces holographic‐like effects & hidden nanosecurity codes that get embedded directly into the products during the process of plastic moulding. Our technology is unique in nanoengraving on flat & curved surfaces of moulds. It can be used in mass production of plastic-based products without prohibitive CAPEX investments. Morphotonix protection is embedded into the product without violating its purity—we use no additives. We delivered 36 orders & prototypes to 26 different customers & carried out a number of industry trial cases. We are aiming to start scale up of our technology in 2019, targeting €15.3m in revenues by 2022 with 55+ FTEs. In this Phase 1 project we will investigate the new target market segments & develop a strategy to scale.

Keywords: product security
Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Switzerland,Sweden,Sweden,Sweden,France,France,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3129428.16
EU funding (EUR): 3129428.16
Participants: 14
Project status: CLOSED

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be implemented in 6 academic centres and 2 SMEs representing a comprehensive, highly interactive and multidisciplinary partnership.

Keywords: neurodegenerative diseases,synapse,ageing,alzheimer s disease,parkinson s disease,huntington s disease,synaptic plasticity,endosomes,neuropathology
TEMPORAL IMG: Temporal radiation imager for nuclear equipment dismantling and nuclear medicine (TEMPORAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Damavan imaging is developing a breakthrough innovation in gamma ray imaging: Temporal imaging. This innovation can be used for various applications, mostly in medical imaging. The most advanced application in term of development (TRL6) is a Portable Compton Camera for nuclear decommissioning, subject of this proposal. We absolutely need this launch market, but most of our long term value potential is in medical imaging. Our innovation is based on using both spatial and time distribution of photons in monolithic and fast scintillators. It allows better localization of gamma photons in space, time and energy. This innovation is protected by 7 patents claims so far and has been presented in international conferences. Our technology brings better angular resolution, sensitivity and reduced cost to Compton camera. We are currently testing our prototype in the field and have obtained first orders from major actors. The “binocular” Compton camera evolution we are proposing here, will produce a 3D Map of radioactivity in one image allowing cost reduction and a safety improvement for operators in nuclear decommissioning operations. The market for this type of imagers today is 20 M$ but growing quickly (>20%/ year). Our approach is to partner with companies in nuclear instrumentation to overcome heavy barriers to entry in the field, selling them a nearly finished product. Temporal imaging is a generic solution: the biggest existing potential is PET scanners (1,5 G$ +7%/year growth). But developing this business will take 5 years! We have identified new potential markets for our Compton camera where no credible imaging solution exists. We believe we can make strong margin there, with easier entry than in PET but we need a market study to be sure. World is our playground, Europe is our base: more than 80% of our sales are and will be abroad. By being selected for this call we would get critical market information and enhance our credibility for fundraising in Europe.

Keywords: imaging camera nuclear medical export
Biobased self-functionalised self-reinforced composite materials based on high performance nanofibrillar PLA fibres (BIO4SELF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Italy,Germany,Germany,Türkiye,Belgium,Belgium,Greece,Slovakia,Romania,Belgium,Netherlands,Denmark,Denmark,United Kingdom
Call: Fibre-based materials for non-clothing applications (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-03-01
End date: 2019-06-30
Duration (months): 40.0
Total project cost (EUR): 8051688.75
EU funding (EUR): 6772639.25
Participants: 18
Project status: CLOSED

BIO4SELF aims at fully biobased self-reinforced polymer composites (SRPC). To produce the SRPCs two polylactic acid (PLA) grades are required: a low melting temperature (Tm) one to form the matrix and an ultra high stiffness and high Tm one to form the reinforcing fibres. To reach unprecedented stiffness in the reinforcing PLA fibres, we will combine PLA with bio-LCP (liquid crystalline polymer) for nanofibril formation. Further, we will increase the temperature resistance of PLA and improve its durability. This way, BIO4SELF will exploit recent progress in PLA fibre technology. We will add inherent self-functionalization via photocatalytic fibres (self-cleaning properties), tailored microcapsules (self-healing properties) and deformation detecting fibres (self-sensing). Prototype composite parts for luggage, automotive and home appliances will be demonstrators to illustrate the much broader range of industrial applications, e.g. furniture, construction and sports goods. Our developments will enable to use biobased composites for high end applications, thus contributing to using sustainable and renewable raw materials. Being able to produce, process and sell these novel SRPCs and related composite intermediates will be a clear competitive advantage. First estimates predict a market of at least 35 kton/year, corresponding to ca. 165 M€, within 5 years. Using the PLA SRPCs, BIO4SELF will demonstrate the first fully biobased suitcase, which partner SAMSONITE intends to commercialise to renew its top selling high end line (currently based on self-reinforced polypropylene). BIO4SELF is a well balanced mix of end-users (large enterprises to maximise impact), technology providers (mainly R&D driven SMEs), R&D actors (RTDs and universities) and innovation support (specialised SMEs). It covers the required expertise, infrastructure, and industrial know-how to realise the innovation potential of the novel high performance biobased SRPCs, both during and beyond the project.

Keywords: self reinforced composites,bio lcp,self cleaning,self healing,self sensing
Design, test, and manufacturing of robust fluidic actuators (DECOROUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Design, test and manufacturing of robust fluidic actuators (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 388750.0
EU funding (EUR): 388750.0
Participants: 1
Project status: CLOSED

This project adresses the development of two-stage no-moving-parts fluidic actuator systems for use in active flow control applications. The work is based on the actuator technology created in the EC-funded Clean Sky projects DT-FA-AFC, FloCoSys, and robustAFC, but goes vastly beyond the scope of those projects, by broadening the view to include real-aircraft constraints and considerations from other-than-aerodynamics disciplines. The project will enable higher TRL experiments to thoroughly validate the concept of local active flow control by pulsed air blowing and will provide a flow control system, which fulfils real-aircraft integration requirements. Through detailed research, it will further the understanding of this flow control actuator concept. Finally, the proposed research, innovation, and development work on the two-stage fluidic actuators of this project will beneficially impact the industrialization of local active flow control by contributing substantially to making such a flow control actuators available on aircraft system level.

Keywords: two stage fluidic actuator,robust actuator
Topological Materials: New Fermions, Realization of Single Crystals and their Physical Properties (TOPMAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-07-01
End date: 2022-06-30
Duration (months): 60.0
Total project cost (EUR): 2070000.0
EU funding (EUR): 2070000.0
Participants: 1
Project status: CLOSED

The topologies of the electronic and magnetic structure in reciprocal and real space underlies much of condensed matter physics. Moreover, the properties of single crystals with particular topological electronic structures can mimic phenomena found in high energy physics and cosmology. New classes of quantum materials are found in insulators and semimetals that exhibit non-trivial topologies: they display a plethora of novel phenomena including: topological surface states; new Fermions such as Weyl, Dirac or Majorana; and non-collinear spin textures such as Skyrmions. A hallmark of many of these new quantum properties that are derived from fundamental symmetries of the bulk, is that they are topologically protected. Just recently a general scheme to identify novel Fermions was proposed that is based on the symmetries and the Wyckhoff positions of relevant space groups. These new types of Fermions are a groundbreaking concept beyond the known Dirac and Weyl and have no high-energy counterparts. The translation of these theoretical concepts into realizable materials is one focus of this proposal. The next step is to apply this approach to magnetic space groups so as to identify new magnetic Fermions. We will engineer these topological materials via synthesising high quality single crystals and by applying for example high magnetic fields and high pressure, to tune topological phase transitions, electrical transport properties and surface states. Particularly high-pressure Hall measurements will be developed. Hall measurements allow the investigation of the fundamental electrical transport properties of topological materials such as their carrier densities, oscillation frequencies, mobilities, and anomalous and topological Hall effects. The PI and her team have already synthesized more than 50 different topological materials as single crystals. To boost topological science in Europe even further a single crystal platform will be established within the proposed project.

Keywords: topological materials,hall effect,single crystals
Informatics approaches for the rational selection of personalized cancer drug combinations (DrugComb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Making cancer treatment more personalized and effective is one of the grand challenges in our health care system. However, many drugs have entered clinical trials but so far showed limited efficacy or induced rapid development of resistance. We critically need multi-targeted drug combinations, which shall selectively inhibit the cancer cells and block the emergence of drug resistance. This project will develop mathematical and computational tools to identify drug combinations that can be used to provide personalized and more effective therapeutic strategies that may prevent acquired resistance. Utilizing molecular profiling and pharmacological screening data from patient-derived leukaemia and ovarian cancer samples, I will develop model-based clustering methods for identification of patient subgroups that are differentially responsive to first-line chemotherapy. For patients resistant to chemotherapy, I will develop network modelling approaches to predict the most potential drug combinations by understanding the underlying drug target interactions. The drug combination prediction will be made for each patient and will be validated using a preclinical drug testing platform on patient samples. I will explore the drug combination screen data to identify significant synergy at the therapeutically relevant doses. The drug combination hits will be mapped into signalling networks to infer their mechanisms. Drug combinations with selective efficacy in individual patient samples or in sample subgroups will be further translated into in treatment options by clinical collaborators. This will lead to novel and personalized strategies to treat cancer patients.

Keywords: drug combinations,personalized cancer medicine