Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technological Choices of Coastal populations : a functional perspective through the use-wear study of knapped lithic tools during the Late Mesolithic (6300-4500 cal BC) in south Norway. (TeCh-Coast)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

TeCh-Coast aims to understand how past populations have used tools and what technological choices they have made to deal with the coastal environment. On the southern Norway seashore, the Late Mesolithic (6300-4500 cal BC) sites constitute a unique knowledge repository of coastal hunter-gatherer populations, in which stone-knapped tools are the most frequent artifacts. However, very little is known about the use of these to exploit coastal resources. How and for what were these tools used? How does their use reflect socially transmitted technological knowledge to exploit coastal resources? Through an innovative and interdisciplinary techno-functional approach, TeCh-Coast aims to bring new functional data on the use of lithic tools to further understand the technological choices of coastal populations. Analyses of the plastic deformations on the surface of the tools due to their use (i.e. use-wears) will be performed on three preselected lithic assemblages. In addition, an experimental analytical program will be set to identify quantifiable wear attributes in lithic tools resulting from the exploitation of marine animal resources by means of confocal scanning microscopy. Finally, by combining observations with a dynamic technological approach and landscape archaeology, the project will aim to identify the technological choices of the coastal groups. More widely, the present project will provide a broader perspective on the Atlantic European seashore, allowing cross-regional comparisons with other coastal groups. The TeCh-Coast project results will have an important impact on the research of the coastal Stone Age hunter-gatherer populations, as well as bring new methodological perspectives to use-wear studies. The results will be disseminated by open-access publications and outreach activities. Through a prehistoric perspective, the project aims to engage in the social debate about the role of technology in the exploitation of environmental resources in the present.

Keywords: coastal hunter gatherers late mesolithic technological choices lithic knapped tools use wear studies functional analyses confocal microscopy
Structural variants impacting peripheral neurodegeneration (STRIPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Many Mendelian diseases have benefited from next-generation sequencing (NGS) technologies for gene discovery and the establishment of molecular diagnosis. However, the technical limitations of NGS pose a challenge for identifying mutational mechanisms in genomic regions impenetrable by these technologies. I hypothesize that complex genomic rearrangements called structural variants in these loci can explain a significant proportion of missing heritability in many monogenic diseases. To this end, I propose to investigate the involvement of structural variants in the pathogenesis of Charcot-Marie-Tooth disease (CMT), the most common genetic affliction of the peripheral nervous system. I will utilize long-read Nanopore sequencing in a unique patient cohort to look for potentially disease-causing structural variants. I will then adopt genetic and functional in vitro and in vivo approaches to characterize the identified genomic variants and ascertain the associated functional genes that most likely underlie molecular pathology. The findings of my pioneering study will highlight the contribution of structural variants in peripheral neurodegeneration, discover non-conventional mutational mechanisms long overlooked by state-of-the-art technologies, and deliver in vivo models that might provide clues for therapeutic approaches for peripheral nerve disorders with common etiology.

Keywords: long read sequencing,structural variation,peripheral neuropathy,charcot marie tooth disease
A dynamic, ultra-stable, random-access RNA retrieval database (DURA-store)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden
Call: EIC Pathfinder Challenge: DNA-based digital data storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1659570.0
EU funding (EUR): 1659570.0
Participants: 1
Project status: SIGNED

In order for DNA to become the information storage medium that serves as an alternative to existing digital storage solution technologies information must be stored stably in it with the means to repeatedly access and manipulate parts of the stored data. Only few in vitro approaches are capable to address some of these requirements, while in vivo approaches still produce largely static data storage libraries, which limits the real-life applicability of these technologies. In this proposal we present a new, regeneratable solid state storage system consisting of beads, where information, encoded in single stranded DNA strands, can be added, selectively accessed and removed using enzymes and nucleic acid strands as inputs for the different data operations in isothermal reactions with no loss of material. To achieve this a strand architecture is proposed, where unique Data ID sequences are used on the targeted data strands for performing the intended data operations via enzymatic reactions: addition, deletion of data and transcription-based data access. Furthermore, a variant of this system is proposed that uses RNA molecules for the selective access of the data strands, which we aim to implement in a bacterial data storage system as well where RNA encoding bacteriophages will be used as a non-invasive way to introduce inputs for the data operations, such as random data access and removal. Finally, we present the use of damage suppressor proteins from extremotolerant organisms complementing the in vitro and in vivo system to provide the long-term stability of DNA observed in resilient biological systems.

Keywords: dna storage,enzymatic reaction engineering,bacteriophage engineering
Researching and Encouraging the Promulgation of European Repertory through Technologies Operating on Records Interrelated Utilising Machines (REPERTORIUM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Italy,Finland,Germany,France,United Kingdom,Lithuania
Call: Europe’s cultural heritage and arts - promoting our values at home and abroad (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2493650.5
EU funding (EUR): 2493650.25
Participants: 13
Project status: SIGNED

Music, as one of the most preeminent European artforms that has impacted worldwide cultural heritage, has an intrinsic value enriching our lives. However, music manuscripts frequently remain private, unshown, or unexploited because they are only available as printed or handwritten in local archives. REPERTORIUM aims to: 1) to provide a technological platform for curating databases of mediaeval and classical European art-music works, linked to other relevant existing databases around the world and fed by automated manuscript digitisation and music information retrieval techniques based on Artificial Intelligence (AI); and, 2) leveraging the above technology to create state-of-the-art audio recording and instrument separation technologies (AI-based, stochastic signal processing, and ambisonics spatial audio) targeted at music education institutions (conservatories), professionals (musicians and orchestras) and the public (streaming services). Combining a novel digitisation tool that leverages AI and Deep Learning solutions to perform Optical Music Recognition and Music Information Retrieval across multiple music datasets opens valuable solutions to problems affecting music businesses while efficiently preserving and rendering accessible European musical heritage. Thus, it is possible to provide cost-effective solutions for immersive streaming and virtual reality experiences by leveraging Sound Source Separation and Spatial Audio technologies. The consortium includes musicologists (ICCMU, MMMO, UOXF), a musical organisation (AHECG), an orchestra (LNP), and a company focused on early music (ODRATEK). Its members have been previously awarded funding by the EC for RIA projects (TUNI, POLIMI, ICCMU, UOXF), UJA has experience in coordinating H2020 projects. It is composed of a balanced combination of research participants and industrial / commercial partners, from 8 European countries (4 universities, 2 RTOs, 2 NGOs, 1 orchestra and 3 companies in the music sector).

Keywords: music,medieval,classical,opera
Investigation of aggregation-prone and phase-separating systems using Pressure-Jump NMR (Pressure-Jump NMR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 217381.68
EU funding (EUR): 217381.68
Participants: 1
Project status: SIGNED

The pioneering work of the Bax/Anfinrud groups saw the development of a pressure-jump system that could reliably, and reversibly, change the pressure of an NMR sample by 2.5 kbar in under 5 milliseconds. The development of the system is currently at a point where tens of thousands of pressure jumps can be performed before maintenence is required, which has opened the door to acquisition of multidimensional NMR datasets, with convolution of pressure and time as a readily-manipulable dimension. This cutting-edge technique is only currently available to a couple of NMR groups in the USA. This project seeks to establish the novel field of pressure-jump NMR within Europe. Initially there will be an implementation phase, followed by further development of pressure-jump NMR methods to investigate aggregation prone and phase separating biological systems. Pressure-jump NMR allows for direct observation of: protein folding pathways, protein aggregation kinetics, phase separation behavior, and both structural and dynamic information about proteins (or small molecules) in a phase-separated or aggretated state and presents the opportunity to re-define the role of NMR in structural biology and biophysical chemistry.

Keywords: pressure jump nmr,protein aggregation,liquid liquid phase separation,protein folding
NeuroLINCS:FIRST-IN-CLASS, NON-INVASIVE, LOW COST & HIGHLY ACCURATE IVD BLOOD-TEST FOR THE PREDICTION AND EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE AND DEMENTIA, BASED ON CIRCULATING LONG NON-CODING RNAs (NeuroLINCS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2499500.0
EU funding (EUR): 2499500.0
Participants: 1
Project status: SIGNED

The escalating prevalence of Alzheimer's Disease (AD) and related dementias necessitates improved diagnostic methods. Over 50 million people globally suffer from dementia, with AD accounting for 60-70% of cases. By 2050, this number is projected to triple, placing immense pressure on healthcare systems and emphasizing the need for early diagnosis to enable timely intervention and personalized treatment plans. Traditional diagnostics like PET scans and CSF tests detect AD only after significant neuronal damage and struggle to efficiently differentiate between various dementia types. Current state-of-the-art IVD blood tests typically focus on amyloid and tau proteins, indicators present only after the disease has progressed significantly. Despite recent advancements introducing new biomarkers such as the p53 protein, commercial tests like AlzoSure® still face limitations in early detection and comprehensive diagnostics. Addressing these challenges, AMONETA has developed the NeuroLINCs IVD diagnostics kit utilizing company-patentented circulating long non-coding RNAs (lncRNAs) to detect AD and five other dementia types up to six years before clinical symptoms manifest. Priced at €200 per test, it offers a non-invasive, cost-effective solution with ≥96% specificity and sensitivity. NeuroLINCs outperforms existing methods by providing a more comprehensive diagnostic tool capable of identifying multiple types of dementia from a single test, a significant advancement over current tests focused primarily on amyloid and tau proteins. Our solution fills a critical gap in the market by offering earlier detection and broader diagnostic coverage. Our commercialization strategy involves strategic partnerships with leading biotechnology and pharmaceutical firms to maximize market penetration and impact. The EIC Accelerator grant will fund design finalization, production, and extensive validation studies across large cohorts, aiming for CE-marking under IVDR and FDA clearance.

Keywords: alzheimer s disease,dementia,ivd blood test,lncrnas,biomarkers,non invasive diagnostic tests
Radiomic Analysis and Data Insights for Enhancing Hepatocellular Carcinoma Immunotherapy Outcomes (RADIANT-HOPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and third leading cause of cancer-related death worldwide. Most patients are diagnosed at an advanced stage. For advanced HCC immunotherapy has been approved as the standard-of-care first-line treatment. However, only about one third of patients respond to immunotherapy. How to predict immunotherapy efficacy and early identify HCC patients who are likely to benefit from it is an urgent clinical problem. RADIANT-HOPE aims to address this problem by developing and externally validating a radiomics model based on clinical routine computed tomography (CT) images. To achieve this, a novel comprehensive framework will be proposed to automatically segment the tumor, expand the tumor margin, and extract radiomics features from intra- and peritumor regions at pretreatment triphasic CT images. These features will be unsupervised clustered into clinically meaningful sub-phenotypes, and patients are stratified into different risk groups of immunotherapy response. Multi-omic data (e.g. mRNA) will be profiled and compared between the sub-phenotypes. Radiogenomic analysis will be performed to evaluate their genomic foundation. The model will be validated in independent international cohorts and developed as software for facilitating clinical utility. This project adopts highly interdisciplinary and intersectoral approaches, integrating oncology, immunology, radiology, artificial intelligence, and bioinformatics. The proposed radiomics model has the potential to provide a non-invasive, accurate, wide accessible imaging biomarker for predicting immunotherapy efficacy and patient stratification. The model implementation in clinic will contribute to HCC personalized treatment, optimize healthcare resources allocation and significantly reduce healthcare costs. As a hepatobiliary surgeon and clinic-oriented researcher, my extensive experience in HCC and radiomics & AI makes me an ideal candidate to conduct this project.

Keywords: hepatocellular carcinoma immunotherapy radiomics machine learning artificial intelligence imaging biomarker
Improve the shelf life of perishable goods through stabilization of vitamins (ImproVITA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-12-01
End date: 2025-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Food processing industries face great pressure to increase the shelf life of goods decreasing the tons of waste generated every year. At the same time consumers are becoming more conscious about their choices and more critical about the use of synthetic preservatives. The most common group of chemical compounds used to preserve the freshness of food are vitamins, also known as antioxidants. Antioxidants are compounds capable to inhibit oxidation which is a chemical reaction that leads to the production of free radicals, involving the possible damage the cells. Antioxidants, such as vitamins (vitamin C - ascorbic acid or vitamin E - tocopherol) end these chain reactions. For that reason, many food supplements and cosmetics are constituted by these vitamins. To prevent their early degradation is of maximum interest and it is the objective of this project to disclose the use of deep eutectic systems (DES) to increase the shelf-time of these compounds. DES are mixtures of two solid species that at particular molar ratio form a new compound with different properties. The team has demonstrated already that the use of this technology enhances the antioxidant activity up to 5 days, and prevents fruit oxidation up to 48 hours, contrarily to what happens with conventional methods which only prevent food oxidation up a couple of hours. Within this proof of concept, the team intends to validate the product in terms of its technical features but also validate the market and evaluate the commercial potential of our solution.
Physics for all (PICO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Greece,Italy,France,Spain
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 322965.71
EU funding (EUR): 305836.25
Participants: 10
Project status: SIGNED

Throughout the past decades, cutting edge research in the frontiers of Physics (astrophysics, gravitational waves, particle physics, astroparticle physics) has provided us with major discoveries and applications and has launched impressive initiatives in the Physics of the very big and the very small. Despite the dissemination effort aiming to inform both the public and the school community about these initiatives and their impact to society, a gap exists between research and society/education which might help to spawn misconceptions about the content, context and mission of science and thus, lead citizens to fall prey to anti-intellectual attitudes and stereotypes. To this end, PhysICs fOr all - PICO - aims to support all citizens to increase their awareness of fundamental, cutting-edge physics and of the impact that discoveries in this field have on their everyday lives with a specific focus on equity, diversity, accessibility, inclusion and gender equality with targeted activities focusing especially on students. By bringing together major European research institutions in the fields of frontier Physics and Science Education as well as partners with high expertise in communication, media and marketing, PICO will forge sustained links between researchers and citizens and coordinate Researchers’ Night and Researchers at schools activities in 2024 and 2025 in 4 countries (Greece, Italy, France, Spain), aiming to engage more than 40,000 citizens and inspire more than 2,000 students in science and attract them to scientific careers.

Keywords: physics,citizen science,gender bias,inclusion