Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards a computational account of natural sequential behavior (ACTOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1964000.0
EU funding (EUR): 1964000.0
Participants: 1
Project status: SIGNED

Imagine navigating through your kitchen, walking around your table and chairs, reaching the counter, sliding a cup on the countertop, pouring yourself some coffee, and preparing a sandwich. Such an every-day situation requires a sequence of behaviors involving the sophisticated interplay of perception, attention, cognition, planning, and action, all unfolding in an ambiguous and uncertain world. Yet, although past research in the behavioral sciences has revealed many properties of these constituent faculties, the understanding of how humans coordinate these cognitive abilities when carrying out every-day tasks is still rudimentary. The goal of this project is to carry out behavioral experiments and develop computational models to identify and characterize perception, cognition, and action in the wild. Our hypothesis is, that sequential actions involving perceptual uncertainty, action variability, internal and external costs and benefits can be understood and modeled in the unified framework of optimal sequential decision making under uncertainty. To achieve this goal, we integrate ideas and methods from psychophysics, statistical decision theory, active vision, intuitive physics, optimal control under uncertainty, navigation, and inverse reinforcement learning. The proposal is structured in such a way that subsequent work packages consider tasks with increasing naturalness, from classical psychophysical production tasks, visuomtor control, to navigation and sandwich making. We will develop methods that allow recovering subjects’ perceptual uncertainties, beliefs about tasks, their subjective costs and benefits including effort, and action variability. Based on our previous experimental work on visuomotor behavior and theoretical work in modeling such behavior on an individual-by-individual and trial-by-trial basis, we seek to elucidate, how perception, cognition, and action are inseparably intertwined in extended, sequential behavior.
Reassessing Bacterial Cell Cycle Regulation: Revealing Novel Regulatory Principles in Realistic Environments (REalCYCLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499926.0
EU funding (EUR): 1499926.0
Participants: 1
Project status: SIGNED

Antibiotic resistance is quickly becoming one of the greatest healthcare challenges of our time. It is soon expected to claim more lives annually than the COVID-19 pandemic or cancer. Yet, the urgency of this problem is not reflected in our efforts to solve it. Because blocking bacterial growth is key in treating disease, greater insight into the bacterial cell cycle is needed. Currently, the bacterial cell cycle is primarily studied under optimal lab conditions. This is equivalent to studying the behaviour of an animal kept prisoner in a zoo. Although valuable observations can be made, essential information will be missed. To obtain a more accurate view of bacterial growth, I will investigate the cell cycle of the major human pathogen Streptococcus pneumoniae while applying clinically relevant stresses. Based on my first-hand experience with the S. pneumoniae cell cycle, I hypothesize that many cell cycle regulatory mechanisms have been overlooked thus far because of their relatively low importance in optimal growth conditions, which are rarely encountered in reality. I will identify genes involved in such cell cycle regulatory mechanisms at a genome-wide scale using an innovative approach I developed for this purpose. In contrast to fitness-based nonspecific read-outs, I will perform FACS-seq (fluorescence-activated cell sorting-based sequencing) to select mutants in which specific cell cycle processes are altered based on appropriate fluorescent read-outs. After identifying the selected mutants, I will characterize the molecular mechanisms involved and investigate their level of conservation. My research will substantially advance our understanding of how bacteria regulate their cell cycle when exposed to real-life stresses. My results can therefore provide a starting point for the development of new antimicrobial therapies that target mechanisms important for growth in vivo. Given the emerging antibiotic resistance crisis, such efforts are urgently needed.

Keywords: cell cycle regulation,stress response,bacteria,streptococcus pneumoniae
EUROPEAN TECHNOLOGY AND INNOVATION PLATFORM BIOENERGY - SUPPORT OF RENEWABLE FUELS AND ADVANCED BIOENERGY STAKEHOLDERS 2022-2025 (ETIP-B2022-2025)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Austria,Sweden,Belgium,Italy,Bulgaria
Call: Support to the activities of the ETIPs and technology areas of the SET Plan (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 997988.13
EU funding (EUR): 997988.13
Participants: 5
Project status: CLOSED

The European Technology and Innovation Platform Bioenergy - Support of Renewable Fuels and Advanced Bioenergy Stakeholders 2022-2025 (ETIP-B2022-2025) project aims at triggering collaborative efforts of stakeholders from research to innovation to implementation in the field of renewable fuels and bioenergy. The project will support and empower stakeholders´ contributions to the Green Deal and the Strategic Energy Technology (SET)-Plan. The European Technology and Innovation Platfrom Bioenergy (ETIP Bioenergy) aims to actively engage with stakeholders and civil society, link their needs to policy making of the European Union and Member States, and to provide advice to industry. The ETIP-B2022-2025 project´s objective is to support ETIP Bioenergy in this task. To achieve these objectives, the project will facilitate Steering Committee and Working Group meetings for ETIP Bioenergy, provide information on research and innovation activities, related technologies and policies on the ETIP Bioenergy website, engage with stakeholders from all involved sectors for information exchange and to provide a basis for ETIP Bioenergy documents, form citizen´s panels to develop citizen´s visions on the role of renewable fuels and bioenergy, and develop policy recommendations. Specific features will include facilitating an update of the Strategic Research and Innovation Agenda (SRIA), a biofuels and bioenergy innovation challenge (BBIC), a policy workshop, two Stakeholder Plenary Meetings (SPM) and the development of a financial independence plan for ETIP Bioenergy. All activities will be widely communicated through newsletters, social media postings and dissemination events.

Keywords: multi stakeholder support bioenergy,renewable fuels,biofuels,set plan,stakeholder engagement,outreach to civil society
(RE)Using Empty Buildings: Adaptive Architectural Types as an Instrument of Social Inclusion for Youth Homeless (ReYouth_Types)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-28
End date: 2028-03-27
Duration (months): 28.0
Total project cost (EUR): 225917.16
EU funding (EUR): 225917.16
Participants: 3
Project status: SIGNED

In 2020, the OECD estimated that circa 38 million buildings in Europe were empty, exposing underlying governance weaknesses for adapting and reusing empty buildings. This needs to be put into perspective with circa 700,000 homeless youth living rough or in emergency lodging each night in Europe. An obvious societal paradox, therefore, exists between the high availability of empty buildings and youth homelessness, calling for a more inclusive and cohesive social dwelling model. These challenges are not new, and architecture has long attempted to solve them through, for example, segregated clustering of architectural types-buildings such as Montagu Burgoyne youth pastoral colony (1829, Potton, UK). My research project, however, aims to critically compare successful contemporary architectural types-buildings of So Stay Hotel (2016, Gdańsk, Poland), Intersectional City House (2016, Wien, Austria), Rukkila (2008, Helsinki, Finland) and Pieter de Raadtstraat 35 & 37 (2014, Rotterdam, Netherlands), their morphologies, programmes of activities, design processes, experiences, ownership structures, governances offering novel socially inclusive collective dwelling-work-trainings models for homeless youth through the use of empty buildings. Through a 2-year fellowship at Polimi - under the supervision of Prof Carolina Pacchi, a leading expert in European cities’ development, a 3-month secondment at TU Delft and a 4-month non-academic placement with ‘Avanzi’ - involving on-site archival research, post-occupancy, semi-structured qualitative interview and co-design methods, I intend to conceive a theoretical framework on ‘ReYouth Types’ and to implement ‘ReYouth Types toolkit’, a new set of design principles. Thus, I will provide European educators, urban and architectural designers, local authorities and civil society with a research and design instrument to reduce the social exclusion of homeless youth while increasing awareness through the adaptive reuse of empty buildings.

Keywords: adaptive reuse of empty buildings architectural types
Effect of bioactive compounds from novel tomato on glycaemia - short title (Bioactive compounds Impact on Glycaemia) (BIG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 169118.96
EU funding (EUR): 169118.96
Participants: 1
Project status: SIGNED

Combining nutrients that act synergistically and have potential to lower postprandial glycaemia is an important dietary strategy that can reduce the risk of developing non-communicable diseases. Within a starch-based food matrix, like bread, the presence of bioactive compounds (polyphenols and carotenoids) can lower or delay starch digestion, and therefore the postprandial glycaemic response. This shows potential for development of bioactive-rich starchy foods, as an alternative to conventional high-glycaemic foods. Variations in dose, form and processing can result in bioactive-rich functional foods with different glycaemic potencies, thus further studies are needed to determine the role of polyphenols and carotenoids from tomato during digestion. The aim of this project is to determine the impact of polyphenols and carotenoids from tomato (naringenin and lycopene, respectively) on nutrient accessibility and impact on glycaemia. I will investigate the interaction of naringenin and lycopene from an organically grown tomato paste enriched with tomato skin, previously developed by the host group, with starch and starchy foods. Nutrient release from a food matrix and digestion will be measured in vitro at a micro- and macrostructural level, using a single-enzyme digestion system and the INFOGEST standardised static digestion model. To determine the effect of naringenin and lycopene on glycaemia, I will use biological samples from healthy study participants collected before and after 4-week intake of tomato enriched paste, from an ongoing dietary intervention study in the host group. The use of tomato by-products (skin) is a sustainable option to fortify foods, providing added value to scraps without post-harvest extraction of bioactive compounds. Results from this study will provide new mechanistic insight into how tomato bioactive compounds modulate starch digestion and new fundamental evidence on their influence on glycaemia.

Keywords: polyphenols,carotenoids,starch,digestibility,glycaemia
METAcommunities and tHE ROle of habitat networks in safeguarding against biodiversity loss under fragmentation and environmental strESs (Meta-Heroes)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Hungary
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 141782.4
EU funding (EUR): 141782.4
Participants: 1
Project status: SIGNED

Aquatic ecosystems are currently facing an unprecedented biodiversity crisis linked to human activities and with even worse future scenarios. Among many potential drivers, habitat fragmentation still remains as one of the least understood due to its complexity. Furthermore, its interaction with other local stressors such as salinity remains as a major knowledge gap that hinders long-term conservation. Ponds host high local and regional biodiversity and contribute to important ecosystem functions and services. At the same time, the networks of these priority habitats are disappearing worldwide (50-90% of habitat already lost). However, the impacts of fragmentation and salinity increase on their biodiversity are yet to be unfolded. Meta-Heroes aims to shed light on the role of network connectivity in safeguarding biodiversity against environmental stressors by analysing pond communities in a multidisciplinary approach, combining experimental work (mesocosms), empirical data (long-term dataset) and a simulation framework to asses future scenarios (graph-based models). My supervisor, Dr. Zsófia Horváth, has an excellent background in metacommunity ecology and her and the host offer the most up-to-date EU level facilities for carrying out the proposed research with a unique large-scale mesocosm facility, a long-term biodiversity database, and access to cutting-edge techniques (eDNA-based methods). Meta-Heroes will also benefit from collaboration of top international experts. I will bring my taxonomical and modelling skills as part of the two-way transfer of knowledge. The combination of all these will result in robust novel results, informative for both basic ecology and conservation. Both will be disseminated and communicated to different audiences (scientists, practitioners, general public). Overall, meta-Heroes will represent a key milestone to expand my professional network and scientific toolsets enhancing the development of my career as an independent researcher.

Keywords: salinization metacommunity ecology pond ecosystem global change network fragmentation habitat loss community ecology aquatic ecology
Climate change in high latitude fairy shrimps: preventing extinction through landscape genomics and ecological niche modelling (FAIRYSCAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

In climate change scenarios, species become highly dependent on their traits to adapt and survive to new environmental conditions. In species distributed along a wide latitudinal range, selection against immigrants from areas subject to different climate conditions may lead to strong genetic isolation. Genetic isolation minimises the probability of evolutionary rescue, reducing the chances to overcome future climate change effects. In addition, while climate change leads to changes in species distributions, range continuity largely depends on successful migration from the current geographic range. This project aims to combine landscape genomics and ecological niche modelling to predict climate change vulnerability in two fairy shrimp species (Anostraca) from Northern Europe: Branchinecta paludosa and Polyartemia forcipata. These approaches will allow me to detect warm-adapted and cold-adapted populations across the distribution range of the species, characterise these adaptations at the genomic level, identify environmental features that promote population connectivity and evolutionary rescue, and predict future climatically suitable areas and migration success. Project outputs will guide the design of conservation measures that enable the survival of these two fairy shrimp species under current and future climate change conditions. These species account for almost the entire known diversity of high latitude fairy shrimps in the Palearctic, and constitute an essential anchor in the functioning of freshwater ecosystems. Developing this project will drive my training in landscape genomics and ecology, which is essential to route my scientific specialisation towards conservation genomics of invertebrate taxa.

Keywords: adaptive genomic variation,neutral genomic variation,landscape genomics,fairy shrimps,anostraca,branchiopoda,freshwater,temporary wetlands,enm,climate change
MEET RESEARCH TO CONNECT SCIENCE AND SOCIETY (Co.Science)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 314397.15
EU funding (EUR): 314397.15
Participants: 6
Project status: SIGNED

The role of science in our societies is strongly related to the creation of new knowledge to face the big challenges of our modern world, the improvement of education, and the increment of life quality. However, science and technology are often hidden from non-expert eyes, generating a gap between citizens and scientists. To thrive, science requires support, communication, and discussion. The Co.Science project aims to connect science to society by promoting the importance of research and innovation, by making science education attractive for youngsters, and by providing researchers with effective communication tools, bringing them closer to the citizens. The way to achieve these goals will go through 1. the implementation of public spaces where researchers and citizens meet face to face; 2. the empowerment of researchers in their communication skills; 3. the establishment of an ecosystem of people and institutions working together to engage citizens in science and 4. the public recognition's boosting of research and science education. The proposal is supported by a consortium of formal and informal learning institutions working together with institutional and civil stakeholders for effective and lasting public engagement and new and appealing opportunities to interact with citizens. The Co.Science project will specifically train researchers on the enhancement of their communication skills and it will organize two ERN editions, implementing educational initiatives in the schools. ERNs will be implemented in six important cities of Lombardy in Italy (Milano, Como, Varese, Busto Arsizio, Lodi, and Lecco) creating cross-disciplinary and multi-topic diffuse events on STEAM fields and promoting the European scientific culture. During the related school years, we will propose active learning actions in the schools owing to the presence of researchers among the students, thus re-building confidence, which is fundamental for our communities.

Keywords: education,steam,communication skills,divulgation,research,science,collaboration,inclusiveness,citizens,engagement,students
Early detection of treatment response in breast cancer (RESPONSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Denmark,Israel,Germany
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-06-01
End date: 2027-09-30
Duration (months): 40.0
Total project cost (EUR): 2499230.0
EU funding (EUR): 2499229.75
Participants: 5
Project status: SIGNED

Breast cancer is the prominent cancer among women globally, with over 2 million women diagnosed annually. Even though early detection and advancements in treatment have led to improved outcomes and survival rates, still, 685,000 women died in 2020. It is thus fundamental to select the best treatment for the individual patient (precision medicine) to improve outcome and reduce side effects (personalized healthcare). The challenge is that predicting how well a patient responds to the therapy takes many months and is uncertain. With this trial-and-error approach, patients can be subjected to treatments that have no or very little effect and suffer from side effects. Importantly, precious time can be lost in finding the right treatment. The proposed solution is Hyperpolarized Magnetic Resonance (HypMR) imaging that may be able to detect non-responders to chemotherapy after the first treatments, much earlier than the current 3-4 months of a full treatment cycle. Thus, it may allow clinicians to adjust the therapy to the individual patient to improve the outcome significantly. HypMR is a novel molecular imaging modality that promises to revolutionize diagnostic radiology with a much wider perspective. The project team comprises world-leading academic, public, and industrial partners in the field of HypMR that will conduct the necessary R&D towards multicenter clinical studies and commercialization of the technique, starting with breast cancer as the first use case. RESPONSE will have significant impacts for the SME Polarize. It will represent a major milestone to raise capital and investments needed for the final steps to market (clinical studies). Commercialization of the clinical polarizer and consumables, incl. the contrast agent, is expected to generate cumulative revenues of more than 250M€, 5 years post-market entry. The societal cost savings on treatments, hospitalization and quality-of-life far outweigh the cost of the diagnostic test.

Keywords: hyperpolarized magnetic resonance breast cancer personalized medicine