Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Age of Moderation: Liberal Patriotism in the Mediterranean, 1814-1848 (MODiterranean)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: CLOSED

This project will investigate the transnational conceptualisation and diffusion of moderate liberal thought in Mediterranean Europe in the first half of the nineteenth century. It will explore moderate thinkers’ formulation of a third political way for the future of Europe between revolution and reaction, by focussing on their transnational correspondence across France, Switzerland, Italy, Greece and Spain. While historians have largely neglected the study of moderation theory by regarding it as an unoriginal and self-serving strand of thought, this project’s overarching argument is that moderation theory was an original strand of liberalism, which southern Europeans, in dialogue with their northern neighbours, conceptualised and implemented as an alternative to the political challenges of the revolutionary age. The proposed research presents two new dimensions. First, while historians have recently studied moderation theory in national contexts, this project will be the first transnational history of moderation theory in nineteenth-century Europe. The international scope of moderate liberalism and its application in different national contexts are revealing of its significance in post-revolutionary Europe. The second original dimension is that this project will use moderation theory to investigate the transnationalism of nations-in-the-making in the nineteenth-century Mediterranean. As scholars have recently started studying the modern Mediterranean as a transnational zone of contact, this project will add a further dimension, by focussing on moderation theory as a primary trigger for intellectual encounters in the Mediterranean in the nineteenth century.
On-site biological sensing for aquatic pollutants and biohazards (AquaBioSens)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Greece,Ireland,Denmark,Italy,Austria,United Kingdom
Call: Biosensors and user-friendly diagnostic tools for environmental services (HORIZON-CL6-2023-ZEROPOLLUTION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2470992.5
EU funding (EUR): 2470992.5
Participants: 8
Project status: SIGNED

AquaBioSens aims to drive the decentralisation of tools for the measurement of aquatic hazards and pollution. We will produce and demonstrate new handheld devices to measure contaminants of emerging concern, microbial biohazards and heavy metals. The aim is to make monitoring more efficient and widely accessible, supporting the EU Mission to “Restore our ocean and waters by 2030” Mission, and specifically the Destination “Clean Environment and Zero Pollution”, as well the Water Framework Directive and Marine Strategy Framework Directive. We will achieve this by developing novel analytics based on cutting-edge techniques: i) immunoassays to measure organic contaminants, ii) isothermal environmental RNA quantification for harmful microalgae and fecal coliform bacteria, and iii) two novel whole cell biosensors based on genetically modified diatom microalgae and fish gill epithelia for multiplexed heavy metals quantification and toxicity assessment. These will be coupled with state-of-the art sensors such as acoustic biosensors, multichannel fluorimetry and organ-on-chip microfluidic devices. Low-cost fabrication strategies will ensure that the developed technologies are accessible to end-users, such as industry operators and government inspection agencies responsible for environmental monitoring. New digital real-time data feeds will enable seamless data flows from sensors to the web, including a dedicated live dashboard. The prototype devices will be demonstrated and validated in potentially polluted coastal and freshwater environments in the UK, Ireland and Greece, with the support of local government inspection agencies. Together with measures to disseminate results widely to the international community, stakeholders and citizen science groups, we will maximize exploitation with a view to commercialize the new technologies in future.

Keywords: aquatic pollution,monitoring systems,handheld devices,microfluidics,biosensors,whole cell biosensors,environmental rna,immunoassays,hab,organic contaminants,heavy metals,digital data feeds
The stress granule machinery controls metabolic signalling through mTOR at steady-state (BEYOND STRESS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2220750.0
EU funding (EUR): 2220750.0
Participants: 2
Project status: SIGNED

mTOR kinase is an oncogenic master regulator of metabolism and cell growth and is known to reside in two multiprotein complexes. Upon stress, mTOR is inhibited by stress granules (SGs), which recruit mRNAs and signaling factors to promote survival. Current work largely addresses the functions of SG proteins under stress, focusing on their RNA binding properties and SG assembly. However, non-stress functions are emerging. I propose that SG proteins have prime functions in mTOR signaling at metabolic steady-state, in the absence of SGs. Our preliminary data show that core SG proteins bind mTOR at steady-state and suggest that they are key controllers of mTOR. In BEYOND STRESS, we will investigate SG proteins as a novel class of mTOR regulators at steady-state. By means of deep proteomics, proteo-metabo-flux, RNASeq, systems modelling, mechanistic and cell bio-logical studies, we will identify and functionally characterize the SG interactome of the mTOR complexes. We will delineate the steady-state inputs that signal through SG proteins to mTOR, and we will unravel the mechanistic interplay through which SG assembly impinges on metabolic signaling upon stress. As levels of core SG proteins correlate with cancer outcome, we will explore their linkage with metabolic signaling, prognosis and drug response in breast cancer. BEYOND STRESS is ground-breaking as (i) it links SG protein research in stress to steady-state mTOR signaling; (ii) a unifying paradigm of mTOR regulation at steady-state and stress will open new horizons for research on metabolic signaling; and (iii) SG proteins are emerging as markers and targets for oncogenic signaling through mTOR. While focusing on mTOR and breast cancer, BEYOND STRESS will likely translate to further networks and tumor entities, opening new avenues to signaling and cancer research.

Keywords: metabolic signaling,mtor,lysosomes,granules,nutrients,stress,translation
eddy Retention of Eggs and LArvae in the Catalan Shelf (RELACS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 4
Project status: SIGNED

In the Northwestern Mediterranean Sea (NWMED), anticyclonic eddies (clockwise spinning flows) increase fishes’ eggs and larvae (ichthyoplankton, IP) survival rate by providing protection and nutrients. However, the underlying dynamics of this retention and nursing mechanism remain not fully understood, preventing us from anticipating climate change effects on early life stages of strategic fish. RELACS aims to understand if and how climate change will impact the role of eddies in the survival of IP. Combining three novel tools to quantify the presence of these oceanic structures and I will identify the mechanisms by which these eddies retain and nurse IP. I will explore whether expected changes in future climate change scenarios could affect this mechanism. My interdisciplinary knowledge in physical and biological oceanography will be enhanced by addressing this challenge with data from two novel observing systems that will be available for the NWMED (namely, an array of High-Frequency coastal radars (HFR) and the recently launched Surface Water Ocean Topography (SWOT) altimetry mission), and by using an unprecedented set of NWMED numerical simulations. From the observational side, I will leverage my knowledge on the SWOT altimetry data, and gain skills on HFR during my first secondment at Dr. A. Rubio’s team. I will expand my modelling skills at the hosting institution and during a second secondment with Dr. L. Renault. Then, with the help of Coupled Model Intercomparison Project climate projections, I will develop a series of scenarios for the evolution of the early stages of fishes at the region to contribute to predict the expected changes in fisheries due to changes in the environment. Finally, I will transfer the knowledge of the outcomes to society by creating a report evaluating the risks of climate change for Catalan fisheries, and the need for climate adaptation during my non-academic placement at the Catalan Research Institute for Sea Governance.

Keywords: ocean mesoscale and submesoscale,ichthyoplankton,climate adaptation
European Circular Economy Innovation Valley: the European “dance floor” for circular regions (ECIV)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: COFUND actions
Countries involved: Spain,Netherlands,Sweden,France,Bulgaria,Belgium,Lithuania,Finland,United Kingdom
Call: Implementing co-funded action plans for connected regional innovation valleys (HORIZON-EIE-2023-CONNECT-03, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 27162498.0
EU funding (EUR): 13579061.51
Participants: 19
Project status: SIGNED

ECIV is a dynamic project aiming to boost circular solutions in different European industrial value chains to increase connectivity inside and between different innovation ecosystems. This transformation is essential for achieving the EU's climate neutrality goals and enhancing industrial autonomy while addressing green transformation ECIV aims to create a lively "dance floor" where innovation stakeholders can connect to propose solutions to different challenges of common interest for the regions to achieve circularity in their main industrial value chains. It connects regions in Europe that share interest in CE development, emphasizing collaboration among stakeholders like public bodies, industries, RTOs, etc. The consortium is composed of nine territories from nine countries joining 17 regions. It has been selected based on their innovation capacity, keen interest in the circular economy, and potential synergies within their regional industrial value chains Objectives: To make significant progress in transitioning participating regions and Europe toward a circular economy To generate sustainable growth and development in the participating regions and Europe by capitalising on the economic opportunities presented in the transition to circular economy. Methodology:1)Analysis of the regional contexts and challenges, including policy aspects, strategic planning, and actors in the circular economy. 2)Mission-Oriented Plans: defining specific missions and sub-missions to address the circular economy's transformational goals 3)Connecting the Ecosystems (the Dance Floor): focusing on facilitating connections and collaboration among stakeholders from different regions. It creates a dialogue space, challenges space, and development space to mobilize, engage, and connect regional actors, to solve specific challenges.4)Solving the Challenges by implementing deep tech projects to the proposed challenges selected in a cascade funding 5)Transferring and replication

Keywords: circular innovation ecosystems,circular innovation solutions,interconecting innovation ecosystems,interconecting circular innovatio stakeholders
Development of a groundbreaking additive manufacturing process to scale up the next-generation high-frequency antennas (monoHFA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Northern Waves is a Swedish deep-tech company specialising in additive manufacturing for high-performance microwave components. We aim to accelerate the adoption of next-generation high-frequency antennas by industrialising scalable, additive manufacturing for compact, complex designed antennas, enabling state-of-the-art performance and durability. By 2028, we aim to be Europe's top advanced antenna supplier, expanding globally by 2032. Northern Waves addresses critical needs in high-frequency antenna systems for automotive, aerospace, telecom, and defence. Due to manufacturing limitations, existing solutions are bulky, inefficient, fragile, and hinder innovation. Traditional multi-part antennas are heavy, complex, and unreliable. Plastic additive manufacturing lacks robustness, and metal additive manufacturing has design constraints. Northern Waves' monolithic, fully metallic additive manufacturing simplifies production, boosts performance, improves energy efficiency, and reduces weight by up to 86% and cost by 50%. This allows for conformal shapes, integrated thermal management, and enhanced durability. Northern Waves sells patented B2B monolithic metallic antennas and offers design services. We have supplied 500+ antennas to 59 clients, mainly in Europe and North America. The company is now developing next-generation antennas with 1 µm surface precision for high-resolution automotive radar, satellite payloads, and 5G/6G telecom. The monoHFA (monolithicHighFrequencyAntenna) project aims to advance antenna performance and manufacturability by expanding production to over 1,000 units/month, automating post-processing and inspection for high-frequency applications (300 GHz+), and achieving in-house ISO 9001 and EN9100 certification. The EIC Accelerator funding provides a valuable opportunity for Northern Waves to enhance the company’s leadership in the automotive, aerospace, telecom, and defence industries by scaling production and advancing antenna technologies.

Keywords: additive manufacturing,high frequency antennas,scale production,advanced microwave components,automotive,telecom,aerospace,defence,future of connectivity
Early identification and remediation of literacy, numeracy, and social-emotional difficulties in kindergarten: an examination of the efficacy of a multi-tiered system of support (MTSS) (MTSS-K)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Luxembourg,Belgium,France,Italy,Germany,Switzerland,Cyprus
Call: Efficiency and effectiveness of investment in high-quality education and training (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3483780.0
EU funding (EUR): 3483780.0
Participants: 8
Project status: SIGNED

Quality education for all is one of the EU’s top priorities. However, several European education systems are regularly pointed out as being underperforming, inequitable or segregated. The core objective of the 4-year MTSS-K project is to adapt, implement and assess the effectiveness and efficiency of a promising American educational approach for kindergarten in five European countries. The so-called Multi-Tiered System of Support (MTSS) aims at reducing inequalities by training teachers to improve the socio-emotional, literacy and numeracy skills of all students and more particularly of the most vulnerable ones. This model calls to adopt evidence-based teaching practices and to regularly and monitor students’ progress on the basis of objective data (Tier 1); to provide early and more intensive group interventions to students who do not progress as expected (Tier 2); and to provide even more intensive interventions to students who continue to need it (Tier 3). This model has been shown to improve equal opportunities of school success and inclusion by significantly diminishing the number of students with learning and behavior difficulties and referred to special education services. However, data is missing as regards comprehensive implementation of this model, its efficacy in kindergarten, its applicability in the European educative systems, and the cost-benefit ratio of this measure. In addition to fill these gaps, the MTSS-K project also aims at making accessible for stakeholders, schools and teachers on a dedicated free-access website evidence-based syntheses, intervention tools, and skills’ assessment instruments developed for the study, to disseminate the results and data in the perspective of the open-science framework, and to make policy recommendations for EU and national authorities.

Keywords: multi tiered system of support,literacy,numeracy,and social emotional difficulties
Automated solutions for sustainable and circular construction and demolition waste management (RECONMATIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Countries involved: Czechia,United Kingdom,Italy,Spain,Greece,China,Cyprus
Call: Automated tools for the valorisation of construction waste (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 6091960.0
EU funding (EUR): 6091958.0
Participants: 23
Project status: SIGNED

A suite of innovative tools, solutions and techniques to build bridges through "bottom-up" construction and demolition waste (CDW) prevention and handling to reach "top-down" European waste reduction goals is proposed. The project's agenda reflects the HORIZON-CL4-2021-TWIN-TRANSITION-01-11 call objectives, with a focus on integrated decision making that would allow considering all aspects of CDW generation and involving all stakeholders within the construction industry. Current practices in CDW management, from prevention and minimization of waste to its reuse, will be evaluated and markets to support the supply chains and circular economies will be identified. Consequently, a digital information management system for stakeholders' collaboration and waste traceability will be developed, tested and demonstrated. It is envisaged that the CDW minimization will be achieved by empowering BIM and integrating waste management relevant data into the information models. Processes of converting different formats of construction information to the digital twins will be automated, as well as the decision-making system for repurposing, deconstruction and demolition. Automation will be employed for AI-assisted CDW classification and robotic segregation off-site. The methodology for CDW logistics in regard to the automatic and more efficient CDW sorting and distribution will be proposed, along with methodologies to provide new added-value uses to CDW. The consortium involves 7 research institutions, 10 small to medium enterprises, 5 large companies and 1 association, representing 5 EU countries, UK and China. The feasibility and efficiency of the developed solutions will be evaluated using 6 demonstrators. This consortium composition will enable us to tackle the whole life-cycle CDW management, propose beyond-state-of-the-art technologies, and contribute to reaching the zero-waste construction industry in Europe in the near future.

Keywords: cdw life cycle waste management end of service life digital twin bim secondary material deconstruction material databank laser scanning sustainability sorting robot waste prediction
Synthesis of Multi-Silencing Polymerized RNA Nanoparticles for Enhanced Cardiac Transdifferentiation via Microneedle Delivery (Multi-R-NPs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

My research aims to advance drug delivery by developing multi-silencing polymerized RNA nanoparticles (Multi-R-NPs) for customized treatments across a wide range of diseases, using engineered microneedles to enhance efficacy. This versatile platform can be adapted for applications such as stem cell differentiation and biosensing, with immediate potential to treat fibrotic diseases like cardiac and pulmonary fibrosis, reducing preventable mortality and improving patient quality of life. Therapeutic transdifferentiation of cardiac fibroblasts into induced cardiomyocyte-like cells could address the limitations of conventional cardiac fibrosis therapies, which typically only manage symptoms and do not prevent the progression of the disease. However, current transdifferentiation strategies face challenges such as low transfection efficiency, uncontrolled gene expressions, and immune responses to viral vectors. This proposal aims to develop multi-silencing polymerized RNA nanoparticles (Multi-R-NPs) through rolling circle transcription (RCT) to enable unique combination therapies that synergize multiple nucleic acid therapeutics. Moreover, to minimize the side effects of untargeted delivery and overcome barriers to cardiac delivery, we will use microneedles to enable local Multi-R-NP transfection. I anticipate that combining two state-of-the-art technologies, RCT and microneedles, will enable the delivery of synergistic nucleic acid therapeutics and promote more optimal cardiac repair through efficient transdifferentiation. During my fellowship at the University of Oxford in Professor Dame Molly Stevens’ lab, I will apply precise control polymerization of therapeutic RNAs and formulate multi-layered polyplex structures. The strong collaborative networks with the British Heart Foundation Centre for Research Excellence and the co-supervision of Prof. Stevens and Prof. Riley will bring out the full translational potential of this project.

Keywords: nucleic acid engineering,rolling circle transcription,cardiac fibrosis,transdifferentiation,microneedle,cardiac organoid