Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Photonics and Quantum Technologies for Sustainable Industry (PhotonQBoost)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: Portugal,Germany,Poland,Austria,Czechia,Finland,Lithuania,France,Spain
Call: 'Innovate to transform' support for SME's sustainability transition (CSA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 6609217.71
EU funding (EUR): 4999665.11
Participants: 15
Project status: SIGNED

PhotonQBoost is committed to empowering European SMEs to achieve sustainability, resilience, and global competitiveness by harnessing the transformative potential of Photonics and Quantum solutions. Recognizing, firstly, the challenges SMEs face in accessing and integrating these advanced technologies due to limited awareness and resource constraints, and, secondly, the potential that technology deployment represents to boost the sustainability and competitiveness of European industry, PhotonQBoost aims to serve as a gateway for European SMEs to match their sustainability and resilience challenges with the solutions offered by Photonics and Quantum technologies. This will be done through a comprehensive pipeline of services, comprising advisory-driven innovation support, technology support and sustainability transition activities, complemented by piloting-driven projects funded under three FSTP open calls. More than €3,6 million will be spent on direct support services to the 600 SMEs that will be onboarded into PhotonQBoost service pipeline. These SMEs will achieve improved KPIs in terms of resource consumption, enhanced productivity and derisked supply chain disruptions. The initiative is also dedicated to fostering cross-fertilization across countries and ecosystems, through matchmaking activities and delegation visits, thereby facilitating market access for SMEs and bridging gaps in knowledge, networks and infrastructure. PhotonQBoost is a strong alliance of seven experienced European Photonics and Quantum clusters, four specialised consultancies and two Research and Technology Organisations, spread across nine EU Member States, that gathers a broad array of competencies. Altogether, PhotonQBoost members will help to consolidate an EU-wide Photonics and Quantum technological innovation ecosystem, ultimately contributing to Europe’s global leadership in both fields and to securing its strategic autonomy in critical technologies.

Keywords: photonics,quantum,sustainability transition,resilience,global competitiveness,service pipeline,innovation support,technology support,resource efficiency,community building
Collision Avoidance and Space Surveillance Innovations for Orbital Protection in Earth Environment (CASSIOPEE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 3071428.75
EU funding (EUR): 2150000.0
Participants: 1
Project status: CLOSED

Through CASSIOPEE, SMS tackles the ever pressing challenge of collision risk management the space industry stakeholders are currently facing. SMS aims to disrupt space surveillance, thanks to its in-novative offering, optical observation stations - based on a patented architecture and proprietary satellite collision prediction algorithms. SMS ambition is to become the first player offering an inde-pendent catalogue of more than 100,000 space debris smaller than 10 cm, and therefore challenge US Air Force monopolistic position. Having access to such cartography is critical to improve space safety in a currently fast-developing landscape in orbital activities. SMS’s catalogue and services address all space actor’s needs : New Space players, satellite operators, industry majors, Space Agencies. SMS purpose is protect opera-tors from of assets losses and performance variations, preserve modern way of life, and ultimately guarantee space exploration remains possible.
Spirocyclic CAMs as novel and ultrapotent anti-HBV drugs (S-CAM) (S-CAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This PoC project aims to advance the development of next-generation direct-acting antivirals (DAAs) against hepatitis B virus (HBV), namely capsid assembly modulators (CAMs) with a novel spirocyclic scaffold chemotype described in our proprietary patent (WO2021/160617). The identification of next-generation spirocyclic CAMs (S-CAMs) during the funding period of ERC CoG 725038 (FATE) represents a potentially important step towards the cure of chronic HBV infection, one of the major uncontrolled medical challenges of our time with a huge economic and social burden worldwide. The novel spirocyclic scaffold represents a major advantage for the progression towards the clinic, thanks to its greatly improved synthetic process and excellent stability in mouse and human hepatocytes. Fewer synthetic steps and a reduced need for costly and hard-to-find intermediates provide a price-competitive production process compared to any other CAM, such as our previous generation non-spirocyclic series (patent WO2020/234483) sold to a US-based biotech company. In addition, our novel S-CAMs have an effective dose in the lower pM range, making these new molecules ultrapotent. In this project we will confirm the technical and commercial viability of the ultrapotent novel S-CAMs that are called to out-compete previous generation non-spirocyclic series still in preclinical and first clinical phases as follows: 1) evaluate the pharmacological properties of the best candidates in normal inbred mice and assess their safety, efficacy and immunostimulatory potential in HBV-replicating transgenic mice; 2) perform a comparative analysis of the main competing CAM solutions; 3) establish the IP strategy and stakeholder mapping; 4) prepare a business plan and commercialization roadmap for in-licensing to a spin-off and mid-term out-licensing to potential strategic partners to bring the best ultrapotent S-CAMs candidates to the market.
Artificial Intelligence Guided Develpment of Vanillin-based Flow Batteries (VanillaFlow)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Austria,Germany,Spain,Türkiye
Call: EIC Pathfinder Challenge: Mid to long term and systems integrated energy storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 4853593.75
EU funding (EUR): 4853593.75
Participants: 6
Project status: SIGNED

The Grand Challenge ahead is to shift fossil-dominated centralized energy systems towards regenerative integrated multi-vector grids. This requires also sustainable electrical energy storage, including the related raw material supply, processes and systems. A real impact on economy, society and ecology is only created if materials, processes and products can be potentially transferred to large scale. This represents a particular challenge for mid to long term, systems-integrated energy storage, also because the EU strongly depends on critical raw materials from politically instable regions. In VanillaFlow, we develop radically new approaches for integrated energy storage which combine artificial intelligence (AI) and machine learning (ML) with flow battery technology to replace currently employed, non-sustainable, and critical raw materials (i.e. redox-active molecules, membranes) in flow batteries by readily-available renewable materials based on starch and lignocellulosics. VanillaFlow will use AI and ML techniques such as physics-informed modeling, causal discovery, and representation learning, and makes use of deep learning and symbolic regression. These approaches are used in designing redox active quinones, and to optimize their interplay with the other components of a battery on single and multi-cell level. The whole research will be guided by toxicology investigations to ensure that sustainable and inherently safe materials will be obtained in the project. Today, the innovation capacity of European scientists and industry in the area of renewable materials makes them already the leading global players in the field. VanillaFlow will further support the European technological leadership in the area by cross-fertilization of different fields (artificial intelligence, battery technology, pulp and paper, biotechnology, polymer technology, toxicity) while addressing needs of sustainable materials in mid to long term energy storage.

Keywords: artificial intelligence,machine learning,organic flow battery
Who Counts? Incorporating a ‘Missing Minority’ to Re-examine the Profile, Drivers and Depth of Poverty across Europe (WHOCOUNTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499584.0
EU funding (EUR): 1499584.0
Participants: 1
Project status: SIGNED

A non-trivial minority of the de facto population are currently ‘missing’ from income surveys used to construct official statistics on poverty across Europe. WHOCOUNTS will correct for noncoverage error in official EU statistics to better understand the changing profile, drivers and depth of poverty across Europe. Whilst those living outside of private households are often part of the inferential population in poverty debates, they are not part of the target population and thus sampling frame of European Union Statistics on Income and Living Conditions (EU-SILC). This undermines our ability to examine the full incidence, composition and causes of poverty because many of this ‘missing minority’ exhibit some of the worst social outcomes across Europe. Much more than merely technical or pragmatic, such practices reflect a set of theoretical and normative judgments about who counts when it comes to researching poverty and social policy. Through novel analysis of hitherto fragmented data, WHOCOUNTS will re-examine poverty across 8 European countries that differ in their noncoverage, demographics, low-income dynamics, and policy interventions. Drawing on adjusted and unadjusted EU-SILC datasets, this project will improve the accuracy of poverty estimates and nuance explanations of (extreme) poverty across divergent welfare regimes, by complementing multivariate regression techniques with (fuzzy set) qualitative comparative analyses. Capitalising on the analytical potential of set-theoretic approaches, the project will transform our understanding of the overall shape and conjunctural causes of poverty across Europe, providing new and necessary information on the social groups often rendered invisible through official statistics. As such, this project promises a step change in our conceptual, methodological and substantive analysis of (extreme) poverty, and will offer future lessons on how poverty statistics can be improved to support better-informed policy interventions.

Keywords: official poverty statistics noncoverage error non private household populations qualitative comparative analysis epistemic erasure
Public Health in Transition. Health Care at the dawn of the Habsburg Empire (1918–1924) (PH in Transition)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovenia,Italy,Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 3
Project status: CLOSED

This project will investigate the transition of the public health system of the multinational Habsburg Empire in successor national states during and after the Empire’s collapse at the end of WWI. The project’s aim is to analyse how health institutions dealt with epidemic diseases and mental illnesses resulting from the war and geopolitical upheavals which reshaped the sense of self and created identity disorientation. As a case study, it will focus on the macro-area between the former imperial capital city Vienna, the main Slovenian urban centre Ljubljana, and the main Habsburg port-city Trieste. The fragmentation of this common space will be observed by comparing three models of transition of the common Habsburg public healthcare system in the three corresponding successor national states: the Austrian Republic, the Kingdom of Serbs, Croats and Slovenes (abbreviated to SHS-Kingdom), and the Italian Kingdom. Three models of adapting strategies will be examined simultaneously from a regional, a national and an international perspective. The research spans from the summer of 1918 until the middle of 1924 – that is, from the establishment of national councils in the different regions of the collapsing Monarchy until the final diplomatic adjustments between Italy and the SHS-Kingdom with the Treaty of Rome, which brought to an end the international crisis concerning the free city of Fiume/Rijeka and established the geopolitical shape of the whole North-Eastern Adriatic area. The project will be developed with the Faculty of Arts at the University of Ljubljana.

Keywords: public health,post ww1 transition,central south europe,gender history,cultural diversity,international health organisations
SOil Innovation Labs: Co-Regenerating And Transforming European Soils (SOILCRATES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Netherlands,France,Spain,Ireland,Italy,Greece
Call: Co-creating solutions for soil health in Living Labs (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 11987357.5
EU funding (EUR): 11987316.25
Participants: 21
Project status: SIGNED

Today, an estimated 60-70% of soils in the EU are (severely) degraded due to unsustainable land use practices and pollution. The SOILCRATES consortium includes 21 partners from across the quadruple helix that fully acknowledge the importance of healthy soils and wish to work together on the tasks defined by the EU Mission ‘A Soil Deal for Europe’. The ambition of SOILCRATES is to create four sustainable and dynamic Living Labs (LLs), to monitor soil health and biodiversity beyond the state-of-the-art, to enhance soil structure and health, and to increase soil literacy in society. During the project lifetime, four LLs based in the Netherlands, France, Ireland, and Spain, will be improving and monitoring the soil structure, soil life, and crop-growing conditions of mineral soils. In these LLs, stakeholders will work with the experimental sites (ESs) land managers to foster innovations and practices suited for the local context. Through co-creation and co-learning, the LLs will increase their knowledge of soils and the underlying soil processes. Special attention would be given to exploring crop diversity and vegetative cover, the application of organic soil amendments and irrigation techniques, and combining these practices at the farm level. By using various educational tools, SOILCRATES will make this knowledge available to the wider public and use it further to inform science, practices, and policy briefs to reduce pressures on soils. By the end of the project, four regional LLs would be fully sustainable and operational. The initial partnership would be enlarged with 40 sub-grantees – ESs and lighthouses (LHs) testing and demonstrating good practices developed through the project (EUR 1,600,000 budget allocated for FSTP). Collaboration will also be established with other LLs, sister projects, JRC, and EUSO. Proposed solutions are expected to spark further regional innovation, uptake of practices and monitoring solutions, and increase the impact of the project.

Keywords: living labs,agricultural mineral soils,soil health and biodiversity monitoring,soil literacy
Light-Frozen Dynamic Covalent Synthesis of Organic Semiconducting Materials (PhotoFreeze)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Designing the materials of tomorrow requires the development of conceptually different synthetic methodology. Creating large conjugated molecular scaffolds often requires many synthetic steps, hindering their exploration and the discovery of new organic semiconductors. PhotoFreeze is a synthetic methodology that combines the best features of dynamic covalent chemistry and conventional covalent synthesis. With this novel chemical approach, a wide range of new functional materials will be developed, namely underrepresented electron-poor organic semiconductors, studied for their important optoelectronic properties. These materials have become essential to the development of organic electronic devices such as Organic Light Emitting Diodes (OLEDs), Organic Solar Cells (OSCs) or Organic Field Effect Transistors (OFETs) among others. The key advantage of PhotoFreeze is that a complex dynamic covalent library of nanographene-based polyimines in exchange can be quickly and irreversibly “frozen” by visible-light irradiation via photocyclization. Such reaction retains and even strengthens the electronic conjugation between the starting materials. This method holds a great promise in the development of a wide variety of imide-based complex conjugated molecular architectures. By varying the reactants stoichiometry, composition, geometry and reaction conditions, a specific target molecule can be prepared in a one pot-sequence. PhotoFreeze will be applied to synthesize various architectures including linear, helical, cyclic graphene nanoribbons, conjugated macrocycles and covalent organic framework. The methodology described here allows the synthesis of otherwise inaccessible or very tedious to prepare large and tuneable structures, and solves fundamental synthetic challenges. The proposed materials hold a great promise for novel high performances organic electronics and will be integrated into relevant devices, guiding the design of future n-type organic semiconductors.

Keywords: conjugated materials,n type organic semiconductors,perylenediimide,organic materials,polyaromatic hydrocarbons,dynamic covalent chemistry
Modular Targeted Nanoplatform for Immune Cell Regulation and Therapy (ImmuNovation)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cancer is a major cause of disability and mortality worldwide. The striking rise of immunotherapies has transformed the way we prevent and treat cancer. Nevertheless, despite the promising clinical results of immunotherapies, they suffer from multiple limitations, including manufacturing challenges, limited efficacy, toxicity, and high costs. Recent data highlight the promising role of personalized cancer vaccines in inducing effective antitumor immunity in patients suffering from aggressive forms of cancer. However, systems suitable for targeted delivery of multiple agents required for long-lasting patient immunity are required. ImmuNovation is focused on TNM (Targeted Nano-immunoModulator), a multifunctional dendritic cell-targeted nanovaccine designed to regulate the function and phenotype of immune cells with a pivotal role in the induction of an effective, specific, and long-lasting antitumor immunity. Here, we will evaluate the technical and commercial viability of our novel nanoplatform (developed during my ERC Advanced Grant, 3DBrainStrom) for the targeted therapy of various cancer types. As proof of concept, we will focus on immunotherapy for CEACAM5+ gastrointestinal (GI) cancers, which affect more than 4.8 million new cases per year and cause 3.4 million related deaths worldwide. The nanovaccine will introduce CEACAM5 antigens and various immune modulators with synergistic mechanisms of action to dendritic cells, thus boosting the immune system’s ability to recognize and destroy GI cancer cells. The proposed nanoplatform represents an affordable alternative to current immunotherapies, with enhanced tumour selectivity, efficacy, and safety profile. My vision is that our nanovaccines will change the landscape of the standard of care for many cancer types. Our platform offers a highly attractive business case, as biotechnology and pharmaceutical companies heavily invest in cancer vaccines due to the need for cancer prevention and therapeutic strategies.