Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis (BURK-6)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 276107.4
EU funding (EUR): 276107.4
Participants: 2
Project status: CLOSED

Secretion systems are evolved machineries enabling bacteria to deliver toxins and virulence factors, called effectors, into target cells to enable the onset of infectious diseases. Uncovering these effectors is essential for the understanding of bacterial pathogenesis and the establishment of appropriate therapeutic strategies to tackle infectious diseases. The recently identified Type Six Secretion System (T6SS) is conserved in environmental and pathogenic Gram-negative bacteria. The T6SS is an organelle structurally akin to an intracellular and membrane-bound contractile phage tail used for the delivery of toxins into prokaryotic and eukaryotic target cells. The importance of this system in the context of infection is highlighted by its ability to not only target eukaryotic cells during bacterial infection, but additionally to target other bacteria co-infecting mammalian and plant hosts. Despite the recent advances made in understanding the mechanisms underlying the T6SS dynamic, very little is known about the T6SS effectors repertoire used by life-threatening pathogens, such as Burkholderia pseudomallei, and for which, vaccine strategies are currently unavailable. In the proposed research, a combination of high-throughput and cross-disciplinary technologies will be used to uncover and characterise novel T6SS effectors in B. thailandensis, a surrogate organism closely related to B. pseudomallei. This will 1) identify new T6SS effectors targeting eukaryotic cells, using a reporter-based transposon screening and 2) identify novel T6SS toxins targeting prokaryotic cells, using a genome-wide saturation mutagenesis strategy. The outcomes of the proposed research will identify the key cellular stages hijacked by the T6SS during the infection of a host, while exposing potential new bacterial targets exploitable for the development of novel antimicrobial strategies.

Keywords: type six secretion system t6ss,effectors,virulence,burkholderia thailandensis and pseudomallei,antibacterial toxins,high throughput,reporter assay,translocation,tradis
European Research Infrastructure supporting Smart Grid and Smart Energy Systems Research, Technology Development, Validation and Roll Out – Second Edition (ERIGrid 2.0)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Spain,Italy,Austria,Cyprus,Greece,Norway,Belgium,Finland,Greece,France,Netherlands,Netherlands,Denmark,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-04-01
End date: 2024-09-30
Duration (months): 54.0
Total project cost (EUR): 9999988.25
EU funding (EUR): 9999988.25
Participants: 21
Project status: SIGNED

A driving force for the realization of a sustainable energy supply is the integration of renewable energy resources. Due to their stochastic generation behaviour, energy utilities are confronted with a more complex operation of the underlying power grids. Additionally, due to technology developments, controllable loads, integration with other energy sources, changing regulatory rules, and the market liberalization, the system’s operation needs adaptation. Proper operational concepts and intelligent automation provide the basis to turn the existing power system into an intelligent entity, a smart grid. While reaping the benefits that come along with those intelligent behaviours, it is expected that system-level developments and testing will play a significantly larger role in realizing future solutions and technologies. Proper validation approaches, concepts, and tools are partly missing until now. In order to tackle the integration of renewables in a first phase the FP7 RI project DERri focused on the provision of access around distributed energy resources. In a second phase, the provided portfolio of services has been successfully enlarged in the H2020 RI project ERIGrid to the system-level covering mainly electric power system, information and communication issues. However, in order to fulfil the challenging goals of the European Union towards a clean, secure, and efficient energy transition to face climate and energy challenges, additional research services are required. In a third phase ERIGrid 2.0 addresses these challenging energy transition aims by widening and advancing the provided RI access. As a single-entry point for researchers active in smart grids, smart energy systems, and integration of renewables, it offers a broad spectrum of improved services, methods, and tools. This will further strengthen the technical leadership of Europe in the energy domain and foster research and innovation to extend its leading role.

Keywords: smart grids,smart energy systems,research infrastructure ri,renewables,sustainable energy systems,validation
Disrupting the elderly home care with contextual analysis software (KYTERA COMPANION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

KYTERA COMPANION aims to disrupt the current setup in the elderly home care market with a real-time monitoring solution detecting emergency situations based on context analysis for elderly people. Elderly people (+65) are a vulnerable category of citizens, with half of them, who experience a long lie after fall, die within six months even if no direct injury has occurred. Thus, the elders themselves, their families and care givers demand a reliable detection solution of such situations. Currently, there are various technologies as panic buttons, accelerometer-based fall detection systems and motion sensors, but they all provide limited, unreliable detection of emergency situations (including many false alarms) and they lack well-being information, which means that daily routines changes remain unnoticed. KYTERA COMPANION, is a pioneering monitoring solution, consists of a wearable wristband, a mesh-network sensor system and a cloud-based software with a mobile app. Our technology can detect up to 95% of both soft and hard falls, through analyzing the elders’ activity patterns and deducing the activity context. Moreover, our solution provides accurate well-being (hygiene, nutrition, sleep) and location (based on full indoors positioning technology and advanced posture analysis) information, achieving almost zero false alarms. On top of that, we enable collateral financial savings compared to Residential Car Facilities for Elderly (can be up to €1,600/month in countries like UK or France). Kytera Technologies is an expert technology SME, consisting of experts with long-term experience from wireless communication industry.

Keywords: elderly care,mesh network sensor system,wristband,mobile app,contextual analysis,software
Denmark and Russia: Why two Arctic empires developed so differently and continue to diverge?” (DEAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-06-29
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

At a time when public attention is focused on differences rather than similarities, comparative studies of Russia and Europe open new perspectives beyond the familiar dichotomous discourse. In this spirit, my MCSA project “Denmark and Russia: Why two Arctic empires developed so differently and continue to diverge?” (DEAR) examines Russo-Danish relations in the 18th and the 19th centuries. For the entire 18th century the two states were very close in terms of economic and institutional development, but after the abolition of serfdom in Denmark in 1800 their paths diverged significantly. This was most striking with the gradual collapse of the Danish empire, and the subsequent rapid development of the remaining territory, whereas Russia remains relatively “backward”, but with its territory largely intact. From the 1860s until the 1920s a much-reduced Denmark became a teacher to its larger partner through the transfer of knowledge, expertise, and experts – a process which aided Russian development, and emphasizes the links between the two countries. The overarching question motivating DEAR is to explore what accounts for the ultimately divergent pathways of the two empires as well as the rapid disintegration of the Danish Empire and the survival of the Russian Empire, given their initial similarities. DEAR combines the expertise of the Historical Economics and Development Group (HEDG) at the University of Southern Denmark (SDU) in Danish economic history and quantitative methods, my research experience in Russian economic history, and the access of both to unique datasets on the preindustrial and early industrial development of these countries.

Keywords: russian economic history,inequality,danish empire,comparative studies
Art and Brain: An integrated approach to causative analysis of neural function in perception of art using Transcranial Magnetic Stimulation (Art and Brain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

This project will bring Matthew Pelowski to Vienna University to undergo a unique two-way program of knowledge transfer and to conduct an innovative, integrated behavioral/neural study of art perception using causative brain manipulation via TMS (Transcranial Magnetic Stimulation). Art is a unique feature of human life. Uncovering how it affects us requires joint expertise in aesthetics, psychology and neuroscience. Employing TMS, we will systematically manipulate three key brain regions (prefrontal, temporal and parietal), while individuals view a selection of art. Cognitive, emotional and evaluative reactions will be recorded via specially designed survey and assessed via a cognitive model which integrates these factors, both of which were created by Dr. Pelowski and which he will introduce to the Vienna group. Simultaneously, Dr. Pelowski will be supported by leading experts in art’s neural study under guidance of host Dr. Leder, and will receive training in TMS. By comparing responses to a control and using Dr. Pelowski's methodology, we will collect a comprehensive within-subject dataset of specific impact of brain regions on art experience. This research will provide the “next step” for clarifying previous cognitive and neurological findings, achieving their integration. It will clarify general questions of brain role in emotion and evaluation. It will also have wide inter-sectoral application to dementia research and art therapy, which will be explored with experts in Leder’s group, and will be a breakthrough to future study of integrated neuroaesthetics and psychology of art. This project will also create a new research direction, expanding from an established center at University of Vienna, continuing a key tradition in empirical aesthetics. It also creates a point of continuing collaboration between Vienna, US and EU, and will further launch the career of Dr. Pelowsk and extend his proficiency to causative brain research.

Keywords: art perception,brain function,cognition and emotion,causative study
UPSCALE OF ELECTRICAL PULSES TECHNOLOGY CAPABLE OF FRAGMENTING HYDROCARBON CHAINS IN FUEL FOR MARITIME APPLICATIONS (AQUASONIC-diesel)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Marine fuels used in ships are considered of the lowest grade as far as the quality is concerned. Massive engines of the ships consume thousands of litres of fuel each day. Fuel cost is one of the most important factors which shipping companies consider while predicting profits. To achieve maximum profit and to reduce pollution from ships, it is extremely important for the propulsion engines to burn fuel oil efficiently. Current actual solutions on the market to improve the combustion of fuel in engines are mainly chemical surfactants/dispersants used as additives with the purpose to homogenize the fuel. The AQUASONIC-diesel solution offers an environmentally friendly alternative in order to improve the combustion process of fuel before combustion by applying electric pulsed power technology to offer the following benefits: • Lowering fuel consumption by 20%, dropping emissions by up to 60% leading to cost savings. • Foreseen for new builds and retrofit without causing any modifications to the marine diesel engines. • Maintenance free, robust, natural and ecological physical treatment of fuel that does not affect the fuel properties, without the application of chemicals (unlike the state of the art). • Selling price between 2.000-20.000 € depending of the fuel flow. Being Spanish market leaders in in electric pulsed power technology, our company Aquasonic has developed and tested this system on a small scale. Through this project we wish to upscale our successfully tested system, certify it according to maritime standards and take advantage of the huge market opportunity.

Keywords: marine transport,electric pulsed power technology,fuel saving
The impact of small-scale disaster events: an exploration of disaster related losses, extensive risk management and learning at the institutional and community level in Italy (SMALLDIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Unlike extreme disasters, smaller scale disaster events receive relatively little attention in Climate Change and Disaster studies even though they occur more frequently and cause considerable damage and disruption to local economic, social, and environmental systems. This project looks at the impact and response generated by extensive disaster events in three regions in Italy as a means of furthering understanding of vulnerability and risk to recurring natural hazards. The project holds significant policy relevance in the fields of development, disaster risk reduction, and climate change adaptation. Despite their cumulative impact, small disasters are frequently left out of national disaster databases, and do not form the focus of national climate change or disaster management policies. As demonstrated by Marulanda et al (2010), the accumulated economic, social and environmental cost of small scale disasters can be higher in comparison to high impact, low frequency events occurring over the same time period. Small disasters are also important because they reveal underlying local development and planning issues that form the root cause of vulnerability to more extreme events. The objectives of this project include 1) a conceptual assessment of mechanisms for capturing data on disaster losses to analyze how definitions impact data accuracy for measuring extensive risk; 2) using alternative sources to build on existing datasets in order to assess the economic, social, and environmental losses associated with extensive disasters for three regions in Italy; 3) examining how disaster management institutions and communities respond to small scale and recurrent disasters, and if such events trigger changes in risk perception, disaster management, and learning at both institutional and community levels; 4) comparisons between quantitative and qualitative impacts of disaster events, and institutional regimes, hazard contexts, and cultural norms for confronting risk.

Keywords: extensive risk,small scale disasters,disaster losses,disaster databases,risk reduction
Advanced Innovation Support Services for SME (AISS4SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Luxembourg
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 70500.0
EU funding (EUR): 70500.0
Participants: 3
Project status: CLOSED

The AISS4SME project aims at offering new services to enhance the innovation management capacities of luxembourg SMEs. 2 target group of SMEs will be address : first, the beneficiaries of the SME instrument and, second, innovative SMEs. This proposal is a response to the Consultation of Enterprise Europe Network partners on the work programme for 2017-2018 H-2020 activities H2020-EEN-SGA2-2017-2018 “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network”, and concerns the set up of coaching and mentoring services for SMEs. It’s our confidence that the AISS4SME proposal is 100% in line with the challenge and scope defined by the EC. Moreover, by pursuing the defined strategic objectives, the project will automatically produce the expected overall impact of: • Enhancing the commercial potential and impact of SME participation in the dedicated Horizon 2020 instrument by ensuring that the project is aligned with and developed as an integral part of the company's innovation strategy, • Achieving tangible organizational change and improved results, • Improving the skill's levels of managers, leaving a legacy such that the SME is better able to overcome the barriers to growth post-Horizon 2020 participation.

Keywords: innovation management capacity,key account management,smes
ESSENCE: Empathic platform to personally monitor, Stimulate, enrich, and aSsist Elders aNd Children in their Environment (ESSENCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Innovation actions
Countries involved: Italy,Italy,Israel,Spain,Cyprus,Slovenia,France
Call: Medical technologies, Digital tools and Artificial Intelligence (AI) analytics to improve surveillance and care at high Technology Readiness Levels (TRL) (H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT, 2020)
Start date: 2020-11-01
End date: 2023-04-30
Duration (months): 30.0
Total project cost (EUR): 3505385.0
EU funding (EUR): 3204573.5
Participants: 9
Project status: SIGNED

ESSENCE aims at transforming the lessons learnt from the COVID-19 in a huge opportunity that exploits technology toward a deep evolution of the services targeting vulnerable populations: non- or pre-frail seniors, and children of the first years of primary school. To contribute to the public health response in the context of the ongoing epidemic, and preparedness for future emergencies, ESSENCE aims at boosting the creation of a new model of home-based care that relies on stimulation, remote monitoring, tele-assistance, and connection between users, families, and professionals. ESSENCE builds upon the results of MoveCare H2020 and adopts an iterative optimization process between two pillars - technology transfer of a subset of successful modules and feedback received from testing on target users – with the final target of achieving CE mark and promptly entering the mark The ESSENCE system consists of three main components: - the Community-Based Activity Center (CBAC), a holistic platform, based on virtual rooms, providing a series of diverse activities with declared recreational, socialization, educational, and assistive purposes; - the Monitoring Module, that gathers heterogeneous information from the activities mediated by the CBAC, a smart ink pen, and diverse applications to extract cognitive, physical, and emotion-related indicators. AI is exploited to provide personalized feedback, and alerts for deviations from physiological behaviors; - the ESSENCE Manager, that acts as the system control unit to manage user profiling, system configuration, possible system malfunctioning, and delivery of notifications, alerts, or feedback. Through ESSENCE, a multi-level user empowerment will be promoted both by: (i) delivering empathic feedback aimed at maximizing engagement and relieving stress; (ii) producing alerts on potential risks to family members and health and education professionals aimed at fostering early detection of possible weaknesses and anticipation of care.

Keywords: medical device,technology transfer,end users field test,social and game engine,iot smart objects,machine interface,assistive living,ecological monitoring