Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Collaborative Radio - Light Detection And Ranging (CoRaLi-DAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Austria,Germany,Netherlands,Belgium
Call: Advanced multi-sensing systems (Photonics Partnership) (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2027-06-30
Duration (months): 54.0
Total project cost (EUR): 4997148.25
EU funding (EUR): 4997148.0
Participants: 6
Project status: SIGNED

This proposal aims at developing an advanced detection and ranging sensor system based on a collaborative scheme, integrating on the same module both radio and light-based sensing. The module will consist of: a silicon photonics solid-state light detection and ranging (LiDAR) chip, with integrated laser source and driver electronics; a CMOS radio detection and ranging (RADAR) chip connected to a single transmitting (Tx) and receiving (Rx) set of antennas; a processing unit (PU) to actively control the two sensors and process the generated data. The LiDAR and RADAR chip will be integrated on the same printed circuit board (PCB) avoiding any use of free space optics. The proposed architecture will allow an active cooperation of the two sensors through an advanced algorithm installed on the PU. CoRaLi-DAR advanced sensor system will exploit LiDAR’s high-resolution capabilities, and RADAR’s strong reliability in adverse weather conditions, to deliver an automotive compatible detection and ranging system. The use of fully integrated photonics and electronics will reduce packaging size, manufacturing cost and ultimately operational power. With CoRaLi-DAR we plan to create a low-cost, low power and reliable sensor system that can be used as a platform for the automotive market and beyond.

Keywords: lidar radar automotive integrated circuits silicon photonics data fusion packaging
Low-Carbon Concrete Structures Prestressed with Geogrids – Flexural Behaviour at Ambient and Elevated Temperatures (SUPERIOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-15
End date: 2028-01-14
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Currently, two main challenges in Civil Engineering are CO2 emissions and energy shortage, as buildings' construction, demolition, and reconstruction consume 10% of the world's total energy, resulting in high CO2 emissions. Reducing the use of steel rebars can significantly improve the sustainability of construction, as the production of steel rebars is highly energy-intensive, polluting, and costly; and mild steel rebars are heavily susceptible to corrosion limiting concrete structures' lifespan by about 40 to 80 years. Unlike steel rebars, geogrids are not vulnerable to corrosion, improve earthquake resistance by increasing concrete structures' ductility/energy absorption abilities and cyclic loading resistance, and have lower weight-to-strength ratios. So, these potentially increase the concrete structures' lifespan and strength-to-weight ratios; and lower the CO2 emissions, energy/resources usage, and cost, making geogrids a low-carbon alternative to steel rebars. This project aims to contribute to the development of low-carbon concrete structures prestressed with geogrids; which are expected to reduce the CO2 emissions at least by 79% per ton of steel rebars replaced and reduce the global CO2 emissions by approximately 4% if disseminated. To promote and expedite the impact and usage of this new innovative prestressing methodology in the construction market, the research project includes: (1) Detailed flexural behavior analysis, (2) Suggesting suitable mitigation methods against high-temperatures, (3) Developing finite element models, (4) Developing design method including strength reduction factors due to aging, and (5) Value engineering study. In addition, this new innovative prestressing methodology expects to minimize excessive plastic deformation, exploit mechanical properties, and increase performance (such as; loading capacity, ductility, and energy absorption) to cost ratios. So, it's a/an sustainable, eco-friendly, economical, and practical choice.

Keywords: flexural concrete beams concrete reinforcement prestressed uniaxial geogrids sustainable concrete structures co2 emissions
Elevating the Future of Cancer care with Alpha Theranostics (Accelerate.EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Belgium,France,Netherlands,Germany,Poland,Denmark,Portugal,Spain,United Kingdom
Call: Development and proof of principle of new clinical applications of theranostics solutions (HORIZON-JU-IHI-2023-05, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 16115520.0
EU funding (EUR): 8007322.5
Participants: 17
Project status: SIGNED

Accelerate.EU, a collaborative European initiative, envisions revolutionising theranostics through innovative targeted alpha-therapies (TATs) using astatine-211. A unique consortium will combine diagnostics with potent cytotoxic effects of alpha-particles to enable precise tumour radiation while minimising side effects. Accelerate.EU's core objectives are: Innovate theranostic solutions based on therapeutic and diagnostic pairs for hard-to-treat cancers, exploring the potential for simultaneous preclinical studies and early-phase clinical trials (i.e. co-clinical approach) to showcase the enhanced benefits of these approaches for cancer patients. • Establish a robust and sustainable EU manufacturing and treatment infrastructure for astatine-211, ensuring compliance with quality assurance and regulatory guidelines while streamlining the supply chain across the EU. • Produce comprehensive educational and training content to support the deployment of theranostic solutions, fostering knowledge dissemination, transfer and longevity/durability Accelerate.EU strategically develop TATs to address unmet clinical needs in pancreatic, breast, and brain cancers. The co-clinical approach, incorporating concurrent clinical and preclinical studies, adds a breakthrough dimension to theranostics. Accelerate.EU pioneers 211At-theranostics establishing a resilient EU scale-up production network and empowering healthcare providers to offer TATs to cancer patients. Through the collaboration of experts from academia, industry and regulatory agencies, Accelerate.EU's implements a visionary approach addressing clinical gaps, accelerating TAT theranostic development, supporting EU global leadership, with primary target to improve patient outcomes for lasting impact on EU cancer care.

Keywords: targeted alpha therapy,tat,co clinical,astatine 211,cyclotron,tnbc,gbm,pdac,substance p,fapi,ntr1i
CellCourier: programmable drug delivery via combinatorial cell targeting and generative design of tailored binding peptides (CellCourier)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

CellCourier aims to revolutionize mRNA delivery by enabling precise cell-type-specific targeting through a data-driven platform that integrates single-cell genomics, computational modeling, and generative AI. Conventional approaches often suffer from off-target effects, leading to unintended side effects. To address this, CellCourier leverages combinatorial peptide binder design to achieve precise cell-type recognition, enabling next-generation delivery modalities such as LNPs or STVs. At the core of CellCourier is a computational pipeline that defines unique surface codes for target cells using single-cell transcriptomic data from the Human Cell Atlas (HCA). This process is enhanced by Nicheformer, a model for predicting cell-cell interactions, and Prophet, a deep-learning model for multi-omics perturbation prediction—both key outcomes of the ERC AdG DeepCell grant. Using these refined surface codes, we apply our all-atom generative model to design peptide binders optimized for high specificity and stability. A competitive binding pipeline, which has shown a threefold increase in hit rates, further refines peptide selection. The process is validated both in silico and in vitro. During the ERC Proof of Concept (PoC) period, we will focus on demonstrating feasibility by targeting the lung using insights from the Human Lung Cell Atlas (HLCA), paving the way for novel treatments for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and lung cancer. Beyond technical validation, we will implement intellectual property (IP) protection strategies, securing patents for advanced peptide binders and their integration into innovative delivery systems. We will also explore commercialization pathways, including spin-off formation and pharmaceutical partnerships for out-license protected IP. By providing the critical tools for precise, cell-type-specific mRNA delivery, CellCourier will establish a scalable and versatile platform, unlocking next-generation targeted therapeutics and transforming personalized medicine.
Archibiome tattoo for resistant, responsive, and resilient cities (REMEDY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Slovenia,Austria,Netherlands,Slovakia
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 2998122.5
EU funding (EUR): 2998122.5
Participants: 7
Project status: SIGNED

The REMEDY project proposes a game-changing technology in the form of an archibiome tattoo that will allow bespoke and high-resolution decoration and functionalisation of new and existing buildings. Our ambition is to achieve a breakthrough in fundamental research in microbiology and synthetic biology, transfer the know-how to materials science in the form of engineered living materials, and develop compatible biofabrication processes that allow personalised design in the architectural context. We propose the customisation of building appearance with living and active interkingdom microbial inks that will act similarly to probiotic skincare products, enhancing biotherapeutic architecture. The tailored and engineered microbial consortia will create a beneficial microbiome, providing resilience and resistance against pathogenic microorganisms, allowing carbon sequestration, oxygen production, and bioremediation among others. We will use the latest metagenomic tools to evaluate the functionome of the created microbial consortia along every step in the development of living inks. In silico analysis will be applied to predict combinations of microorganisms based on genome-scale models of metabolism. Machine learning models will be implemented for predictive analysis of growth patterns and structural outcomes, providing insights for further optimising ink formulations and printing parameters. REMEDY will introduce metabolic thinking in the circular building industry, boost probiotic architecture, and initiate a microbial revolution that aims to change the negative perception of microorganisms in architecture. The “high-risk” idea proposed by the interdisciplinary consortium will deliver a “high-gain” solution in the form of probiotic architecture. REMEDY will provide a new dimension that has not yet existed for conventional materials – life. It will change the way we perceive, experience, understand, design, use, and transform materials.

Keywords: living ink,engineered living materials,biofabrication,microbiome
Implementation of an Integrated Digital Health System for Infectious Diseases in Maternal and Child Health In East Africa (LINDA-FAMILIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Ireland,Tanzania, United Republic of,Norway,United Kingdom,Ethiopia,Rwanda,Uganda
Call: Innovative digital health solutions for sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-08-01
End date: 2029-07-31
Duration (months): 48.0
Total project cost (EUR): 4998562.5
EU funding (EUR): 4998562.5
Participants: 11
Project status: SIGNED

The adverse consequences of infectious diseases, including HIB, hepatitis B, malaria, tuberculosis, syphilis, sepsis, and other poverty-related infectious diseases on pregnant and breastfeeding women and children are well recognised. We aim to scale up the LINDA-FAMILIA eRegistries, an innovative, interoperable, and adaptable open-source digital health information system within the DHIS2 platform (District Health Information Software), replacing paper-based systems in maternal and child health units in the following four regions in East Africa: Addis Ababa Region, Ethiopia; Eastern Province, Rwanda; Kilimanjaro, Tanzania; and Lango sub-Region, Uganda. The four regions have varying clinical and digital readiness needs and challenges. The system is designed to strengthen the health systems using 11 digital health interventions which were selected following WHO guidelines. The system will support clinical research by gathering harmonised longitudinal maternal and child data. The system will support epidemiological clinical research such as trialling vaccines at a low cost by using the real-world routinely collected data. This will speed up the production process of effective vaccines, other preventive measures and allow patients to access treatment and interventions and inform the development/improvement of clinical guidelines and health policies. The LINDA-FAMILIA proposal is in line with national digital health strategies in the four countries and the East Africa Digital REACH Initiative. Our proposal addresses the relevant public health short- and mid-term actions of the AU-EU Innovation Agenda 2023, including enabling improved equitable access to essential healthcare and providing the opportunities to create an international research hub and enhance sustainable global scientific collaborations. To achieve the expected impacts, we are partnering with the Ministry of Health in each country and will provide a country-specific LINDA-FAMILIA sustainability strategy.

Keywords: infectious disease,poverty related disease,maternal and child health,digital health
Noble-Gas Compounds meet X-ray Charge Density and High-Pressure Research (NgCHEM)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia,Italy
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 85699.68
EU funding (EUR): 85699.68
Participants: 2
Project status: CLOSED

This project aims to study noble-gas compounds by X-ray charge-density analysis and explore the structural behavior of selected noble-gas species under high-pressure in GPa range. Experimental electron-density distribution of reactive fluorides is rarely studied and no experimental charge-density analysis on noble-gas compounds has been reported to this date. Moreover, there is a genuine interest in noble-gas chemistry under extreme conditions of high pressure. However, the vast majority of studies are computational predictions and experiment significantly lags behind the theory. The project results would constitute the first X-ray charge density analysis on noble-gas compounds. This would provide new insights into the chemical bonding of noble-gas compounds and nature of their intermolecular interactions. Moreover, diamond anvil cell experiments would significantly advance our understanding of the hitherto unknown high-pressure chemical and structural behavior of noble-gas compounds. An ambitious, but challenging, experimental charge-density analysis of noble-gas compound under high pressure in diamond anvil cell will also be undertaken. Special experimental methods and techniques will be employed for the synthesis and structural characterization of reactive and air-sensitive noble-gas compounds. The two-way transfer of knowledge and skills, therefore represents an important aspect of this project.

Keywords: noble gas compounds,charge density analysis,high pressure research,diamond anvil cell,fluorine,fluorides,crystal structure
TWINNING FOR SMART WATER- THINKING AND RETHINKING WASTEWATER MANAGEMENT IN CIRCULAR ECONOMY FRAME (SmartWaterTwin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,France,Spain
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2025-11-30
Duration (months): 39.0
Total project cost (EUR): 997530.0
EU funding (EUR): 997280.0
Participants: 3
Project status: SIGNED

The Green Agenda for the Western Balkans, through its pillars, addresses the initiatives to support the region in developing circular economy (CE) strategies and fighting pollution of air, water and soil. Driven by increased demands in water, energy and food, and simultaneously with the necessity to reduce environmental impact, the water treatment sector urges for innovative solutions. According to this wastewater can potentially contribute to the nexus of water, energy and material recovery, concerning the circular-economy design. The SmartWaterTwin project aims to boost knowledge and research excellence in the area of sustainable wastewater treatment and management by increasing the scientific and technical capacities of widening institutions. In the long run, SmartWaterTwin will initiate the paradigm-shifting from linear (traditional) toward a circular (future) model in the water sector in The Republic of Serbia. In addition, it will serve as a “soft instrument” for assessing the boundary conditions for circularity by influencing knowledge levels, collaboration and policy creation. Analysis assessment for the potential benefits of the circular economy for Serbia will be performed and can be extrapolated for WB region. Indicators measuring performance towards the development of CE are competitiveness and innovation, which will be unleashed throughout the project objectives. The project will provide an opportunity for twinning in a coherent international approach to the circular economy through developing a comparative analysis from two perspectives - "thinking and rethinking" of circular economy in the water sector. The project will change the perception of wastewater- do not think about waste but about the source.

Keywords: circular economy,wastewater management,sustainability,advanced wastewater treatment
Restoring balance: how axolotls regenerate otoconia for gravity sensing (OTOREG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1977302.0
EU funding (EUR): 1977302.0
Participants: 1
Project status: SIGNED

Gravity deeply impacts all life on Earth. Organisms sense its directionality and use it for orientation. In tetrapods, the gravitational sense relies on biomineral crystals, known as otoconia, in our inner ear. Their movement is detected by sensory cells, transduced into a neural output, and interpreted by the brain. Deterioration of the otoconia can cause severe balance issues, contributing to diseases collectively referred to as vestibular disorders. Yet, the processes driving both otoconia formation and degradation remain unclear. Limitations in diagnosis of balance disorders in humans stem from the inaccessibility of the inner ear for studying which components are functioning deficiently. In this context there is a need to develop models of vestibular function, disease and restoration. The ultimate goal of OTOREG is to uncover fundamental mechanisms underlying gravity sensation, using the axolotl as a model of regeneration and balance disorders. The morphology of the salamander inner ear is strikingly similar to mammals and my preliminary data indicates that removal of otoconia leads to a balance disorder phenotype. Otoconia then regenerate in the axolotl, restoring correct swimming behaviour and providing a functional readout. This system thus permits a holistic, multilevel approach to understand gravity sensation: I) At the biomaterial level, using structural methods to investigate crystal development and regeneration; II) at the molecular and cellular level, to characterize the genes and cells that drive the formation of the sensory apparatus; and III) at the organismal level, using the behavioural readout to test compounds which might contribute to the degeneration or restoration of otoconia. This detailed understanding of the gravity sensation organ can provide a platform for studying and developing therapeutical approaches for balance disorders to improve people’s quality of life, as well as to probe the fascinating biology of our most ancient sense.

Keywords: regeneration,biomineralization,otolith,gravity,sensory organs,grn,salamanders,balance disorders