Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting mechanisms of intracellular cholesterol transport using chemical genetic tools (CHOTENICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Cholesterol is a unique lipid, essential for membrane integrity, cell signalling and cell proliferation. Accordingly, mammalian organisms have evolved an elaborate myriad of mechanisms to control cholesterol transport and distribution within cells. However, our understanding of these mechanisms remains incomplete due to (i) the functional redundancy inherent among cholesterol transporters, which limits their study through conventional genetic approaches, and (ii) the general lack of suitable probes. CHOTENICS aims to address this knowledge gap by exploring intracellular cholesterol transport using a novel chemical genetics approach. The project is built on the hypothesis that fast-acting chemical tools can rapidly modulate subcellular cholesterol distribution, enabling direct dissection of transport mechanisms before indirect effects manifest. To accomplish this goal, a high-content screening assay will be first developed to track cholesterol localisation, and then used to identify small molecules that modulate its transport. Chemical optimisation and mass spectrometry-based target identification will provide target hypotheses that will be further tested using biophysical assays and validated via genetic methods. This integrated approach is ground-breaking since it will reveal cholesterol transport pathways, mechanisms, and drug targets, and will uncover the therapeutic potential of targeting cholesterol transport processes. CHOTENICS is designed to complement the current knowledge of the researcher in chemical synthesis and biological assay development, provide specific training in proteomics and genetics, and equip the researcher with new technical and transferable skills to become a well-rounded chemical biologist. The host organisation will gain from the researcher’s expertise in chemistry and biology and find opportunities to expand its network of international collaborations.

Keywords: cholesterol,intracellular cholesterol transport,chemical genetics,target identification,small molecules
Generic regularity of area minimising hypersurfaces and mean curvature flows (GENREG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2412795.0
EU funding (EUR): 2412795.0
Participants: 1
Project status: SIGNED

Major advances in geometry and topology have been achieved by studying critical points and gradient flows for natural energies, but these analytic methods are hindered when singularities occur. In fact, singularities are the main obstacle in the use of area minimisation in the proof of the positive mass theorem up to dimension 7 and the use of Ricci flow with surgery in the proof of the 3-dimensional Poincaré conjecture. A key observation in geometry and physics is that generic solutions, obtained by small perturbations, can exhibit simpler singularities or even none at all. This phenomenon, called generic regularity, can yield outstanding results. The recent generic regularity breakthroughs by the PI-led group will allow to address fundamental open problems in three areas: For area-minimising hypersurfaces, we aim to extend generic regularity to all dimensions, building on the PI's work in up to 10 dimensions. This would establish the positive mass theorem in all dimensions, bypassing technical analysis of the singular set of minimisers. It would also allow the resolution of other well-known problems related to scalar curvature. For mean curvature flow singularities, which are unavoidable, generic flows are expected to encounter only the simplest types. Work of the PI has proven this in 3 and 4 dimensions up to the problem of “multiplicity”. Bamler–Kleiner recently excluded multiplicity in 3 dimensions. Our goal is to prove that multiplicity generically cannot occur in higher dimensions. This would mark major progress towards the Schoenflies conjecture, a main open problem in 4-dimensional topology. For special Lagrangian submanifolds, fundamental objects in symplectic geometry, we would geometrise Lagrangians in Calabi-Yau manifolds by establishing generic Lagrangian mean curvature flows through singularities. The anticipated contributions to mirror symmetry are expected to impact fields spanning algebra, geometry, topology, and theoretical physics.

Keywords: area minimising hypersurfaces,mean curvature flow,lagrangian mean curvature flow,generic regularity
Electricity market Hawkeye - An online surveillance tool to detect distortions in the supply-side of electricity markets (e-Hawk)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

While electricity is a basic commodity that underpins industrialization, progress and the quality of life of human beings, its production, storage and transmission is strongly constrained by physical laws and its demand is utterly inelastic. All of this together exacerbates the vulnerability of a sector that is vital to modern societies. A critical and vulnerable sector is not only easily affected by external supply shocks, but also susceptible to manipulation and abuse. Spurred by the conviction that Science must serve the people, in this project we plan to develop and demonstrate the efficacy and usefulness of a tool to automatically alert about atypical distortions in the supply-side of electricity markets, such as those caused by the exercise of market power by energy companies with a dominant position. The tool combines such features that make it unique and the only one of its kind: it runs online and automatically, is purely data-driven, only fed with publicly available information, computationally cheap and able to learn and explain the context under which the distortion is more likely to occur. The scientific heart of the tool is Functional Statistics, and to build it, we will exploit novel notions and techniques for the identification of functional outliers that we developed within the framework of the ERC-STG project FlexAnalytics – Advanced Analytics to Empower the Small Flexible Consumers of Electricity. Our ambition is to equip market regulators and operators with a powerful instrument that not only brings benefits in terms of money saved for consumers, reduced time and effort in supervision and monitoring, and shorter delays in detecting potential offenders, but also and above all, allows regulators to fulfill their most sacred obligation more effectively and efficiently: to protect the weak.
Edge AI Technologies for Optimised Performance Embedded Processing (EdgeAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Norway,Austria,Belgium,Germany,France,Italy,Latvia,Netherlands,Greece,Switzerland
Call: HORIZON-KDT-JU-2021-2-RIA-Focus Topic 1-Processing solutions for AI at the edge addressing the design stack and middleware (HORIZON-KDT-JU-2021-2-RIA, 2021)
Start date: 2022-12-01
End date: 2026-06-30
Duration (months): 43.0
Total project cost (EUR): 33341524.23
EU funding (EUR): 10171160.41
Participants: 50
Project status: SIGNED

EdgeAI is as a key initiative for the European digital transition towards intelligent processing solutions at the edge. EdgeAI will develop new electronic components and systems, processing architectures, connectivity, software, algorithms, and middleware through the combination of microelectronics, AI, embedded systems, and edge computing. EdgeAI will ensure that Europe has the necessary tools, skills, and technologies to enable edge AI as a viable alternative deployment option to legacy centralised solutions, unlocking the potential of ubiquitous AI deployment, with the long-term objective of Europe taking the lead of Intelligent Edge. EdgeAI will contribute to the Green Deal twin transition with a systemic, cross-sectoral approach, and will deliver enhanced AI-based electronic components and systems, edge processing platforms, AI frameworks and middleware. It will develop methodologies to ease, advance and tailor the design of edge AI technologies by co-ordinating efforts across 48 of the brightest and best R&D organizations across Europe. It will demonstrate the applicability of the developed approaches across a variety of vertical solutions, considering security, trust, and energy efficiency demands inherent in each of these use cases. EdgeAI will significantly contribute to the grand societal challenge to increase the intelligent processing capabilities at the edge.

Keywords: edge processing,artificial intelligence,hardware architectures,neuromorphic,middleware
A political economy of ova banking in Spain and Ukraine (CryOVAlue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

With the growing international demand for donor ova, Spain and Ukraine have developed into leading suppliers of donor ova for the burgeoning ova donation industry in Europe. The banking of ova and their transnational shipping is the subject of fierce political and ethical debate among policymakers and medical professionals in Europe. While selling human ova is illegal, countries interpret the relevant legislation differently and find regulatory loopholes, which results in an emergence of market relations around the exchange of ova. This growing transnational ova market makes Europe a key nodal point for understanding the process of valuation of human reproductive materials. However, a comprehensive research project on the economic value of ova under different regulatory regimes is currently lacking. CryOVAlue addresses the field’s knowledge gap by asking how the model of ova banking in Spain and Ukraine influences the valuation of ova produced for market exchange. While most of the literature on ARTs focuses on the cultural understanding of reproductive technologies, their restrictions, and experiences resulting from them, CryOVAlue develops a political economic approach. By conducting comparative analysis of the ova banking in Spain and Ukraine, CryOVAlue explores how the value of ova is affected by the countries political and economic position in Europe, and how it shapes the well-being of ova donors. Moreover, CryOVAlue investigates how the Spanish and Ukrainian ova banking industries are impacted by the war, and how they generate value within rapidly shifting regulatory regimes, markets, and state borders. This project is based on multi-sited ethnographic fieldwork, employing participatory observations in the ova banks and interviews with medical professionals, coordinators, couriers, and ova providers, in Spain and Ukraine.

Keywords: ova donation,ova banking,ova providers,assisted reproduction,value,reproductive labor,spain,ukraine,war,political economy,altruism,commercialization,reproductive biomaterials,bioeconomy
Reuse of batteries through characterisation, smart logistics, automated pack and module dismantling and repackaging and a blockchain enabled marketplace. (RECIRCULATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Finland,Norway,Germany,Switzerland,Türkiye,Spain
Call: Streamlined collection and reversed logistics, fully automated, safe and cost-efficient sorting, dismantling and second use before recycling (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 4901817.5
EU funding (EUR): 4901817.5
Participants: 14
Project status: SIGNED

RECIRCULATE addresses the needs of European recycling sector by overcoming current challenges relating to automated dismantling and sorting; safe logistics; fast, cost-effective and reliable State of Health and State of Safety characterization. Combining these advances with a blockchain-based platform, that will combine the data collected during dismantling and recycling and the battery provenance, will enable a unique battery passport and virtual marketplace for e-mobility, consumer and stationary Battery Energy Storage Systems. This approach will enable the RECIRCULATE consortium to create a cascade approach that will enable increased end-of-life battery repair, reuse, remanufacture and recycling. The advances in RECIRCULATE will based on best-in-world innovations, including: • Automated dismantling based on Artificial Intelligence with accurate sorting by SoX and battery provenance for recycling. • Fast, cost-effective, reliable SoX characterization; Safe storage and transportation based on smart logistics solutions. • Blockchain-based Battery Passports that tracks key battery data, and enables both a complete circular system for e-mobility batteries and a unique, blockchain-based virtual marketplace. The unique virtual marketplace will allow for the creation of new circular business models for repair, reuse, remanufacture and recycling of second-life batteries, minimizing cost, time, energy and environmental impact whilst maximizing battery value. RECIRCULATE represents a pan-European consortium of world leading organisations that are looking to commercialize these technologies of European origin. The coordinator, Centria, is leading activities in battery dismantling. The consortium is strengthened by very large organisations, including: Ford, who are currently undertaking development for e-mobility, and DHL a global leader in logistics and reverse logistics as well as European SMEs with world leading technologies.

Keywords: automated dismantling state of health,state of safety safe logistics battery passports virtual market place blockchain reuse remanufacture rapair recycling
The role of fungal viruses in shaping fungal pathogenesis and mammalian host responses (MycoViralPath)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1673925.0
EU funding (EUR): 1673925.0
Participants: 1
Project status: SIGNED

Fungal pathogens present a significant threat to global health. As eukaryotes, they share considerable homology with their hosts, necessitating the development of innovative, non-cross-reactive therapies. Mycoviruses, viruses of fungi, can transform fungal virulence. Yet, despite their ubiquity and importance, the underlying mechanisms driving mycoviral infection and their consequences on fungal pathogenesis remain understudied. Using a naturally mycovirus-infected Aspergillus fumigatus strain, a model human fungal pathogen, we found that the mycovirus bestows a survival benefit to the fungus under oxidative stress and in the murine lung. We posit that mycoviral pressure modulates fungal fitness and virulence, thereby shaping the fungal host repertoire and facilitating the emergence of new fungal diseases. The proposed research aims to elucidate the mycoviral, fungal and mammalian determinants governing fungal cell fate during infection. We will:1) determine the molecular details governing mycoviral impact on fungal fitness, virulence, and host adaptation, 2) identify fungal antiviral mechanisms, and 3) determine how mycoviral infection affects the mammalian antifungal response. This complex multipartite pathosystem (mycovirus-fungal host-mammalian host) is highly heterogenous and dynamic, and this diversity can trigger different infection outcomes. To this end, we have developed a suite of fluorescent probes of fungal and mycoviral infection and of fungal physiology that enable tracking of virus-fungus-host interactions at single-cell resolution, and assessment of the physiological state of phagocytosed fungi in the host tissue. We propose the first in vivo interaction map of a virus within a fungus within an animal in the context of in vivo infection. We anticipate that this work will fundamentally shift our paradigms of fungal pathogenesis, and lay the groundwork for the development of novel therapeutics that operate in an entirely unexploited target space.

Keywords: mycoviruses,invasive mycoses,aspergillosis,regulated cell death rcd,antiviral response,fungal pathogenesis
Linking Ketone Metabolism and Signaling in Heart Failure with Preserved Ejection Fraction (KetoCardio)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1809140.0
EU funding (EUR): 1809140.0
Participants: 1
Project status: SIGNED

Heart failure with preserved ejection fraction (HFpEF) is a burgeoning public health problem for which there are little to no evidence-based therapies. This syndrome has proven particularly challenging because of the limited insight into its underlying molecular mechanisms. Metabolic adaptations are critical for cardiomyocyte response to stress. Ketones are metabolites actively produced in heart failure and their role as metabolic rheostat capable of modulating cardiac metabolism and cardiomyocyte signaling pathways has been postulated. However, there is fundamental, open gap in understanding how ketones are utilized as source of energy in HFpEF and how β-hydroxybutyrate (β-OHB) – the most abundant ketone – plays a role as non-energy carrier governing cardiomyocyte function. In this project proposal, I hypothesize that ketones are major regulators of cardiomyocyte biology representing an alternative source of fuel in HFpEF (“energy” role) and act as protein modifiers trough β-hydroxybutyrylation – a lysine-based post-translational modification (PTM) – thereby regulating chromatin architecture, gene transcription and metabolic signaling in cardiomyocytes (“non-energy” role). The overall aim of KetoCardio is to define mechanisms integrating ketone metabolic adaptation with signaling pathways and epigenetic changes in HFpEF-stressed cardiomyocyte. Coupling proteomics, transcriptomics and genomics approaches together with cardiac and systemic metabolic evaluation and rigorous preclinical experimental modeling of HFpEF, I will be able to define the previously unrecognized role(s) of ketones as energy substrates in HFpEF and as substrate for proteins PTM impacting on cardiomyocyte function. In summary, focusing on metabolic pathways that govern cardiomyocyte abnormalities in preclinical HFpEF, this project will provide a transformative molecular understanding of ketones biology in cardiomyocyte fostering innovation in the field and beyond.

Keywords: hfpef ketones ptms
Knowledge hub to leverage existing initiatives and projects to foster the adoption of Circular economy in Cities and Regions In Europe (CCRI Knowledge Hub)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Spain,Poland,Italy,Belgium,France,Finland
Call: Enhancing collaboration between Circular Cities and Regions Initiative's (CCRI) supporting organisations (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2963744.33
EU funding (EUR): 2612932.04
Participants: 12
Project status: SIGNED

CCRI Knowledge Hub aims at increasing the impact of the existing Circular Cities and Regions Initiative (CCRI) by enlarging the network of involved stakeholders, bringing together the knowledge and critical mass already developed around Circular Economy implementation and building upon the CE stakeholder platform. The goal is to promote and make the circular economy concept a reality in EU cities and regions, in particular in those in the early stage of circular economy transition. To reach its objective, CCRI Knowledge Hub will leverage existing initiatives and projects to foster the adoption of circular economy in EU cities and regions. CCRI Knowledge Hub´s formula is based on three principles: (a) easy access to systematized workable knowledge; (b) tailored mentoring according to users’ needs and (c) effective awareness-raising to make the circular economy more desirable, that build upon four main dimensions: (i) Public engagement; (ii) Innovation and technology; (iii) Business models and financial support; and (iv) Impact evaluation. CCRI Knowledge Hub gathers a multidisciplinary expert consortium of 11 partners from 6 EU countries (research and technological centres, universities, research organizations, international networks and associations, regional authorities as well as specialized companies and SMEs) that bring in complementary skills and competences to achieve the project´s objectives.

Keywords: circular economy,circular economy transition,circularity,circular systemic solutions,european green deal,eu circular economy action plan,sustainable,regenerative economy