Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification of the cellular sites of cytomegalovirus latency that contribute to the induction of inflationary CD8 T cell memory against the virus. (MISTRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

T cell memory is the cornerstone of protective immunity and the key determinant of the efficacy of vaccination approaches. Memory inflation (MI) is a unique type of CD8+ T cell memory characterized by the induction of robust and durable populations of functional effector/effector memory CD8+ T cells that is elicited by latently persistent cytomegalovirus (CMV) infections. Accumulating evidence argues that inflationary T cells can provide exceptionally strong immune protection. Hence, several translational approaches involving MI, such as CMV vector-based vaccines, are subject of ongoing pre-clinical and clinical projects. Despite this, little is known about the cellular and molecular mechanisms governing the induction and maintenance of MI. In this proposal, I aim to identify and characterize the latently infected cell type/-s, which sustain CMV-specific inflationary CD8+ T-cells. To this end, I will combine state-of-the-art stromal cell characterization and isolation techniques with generation of novel recombinant virus-based in vivo models enabling (1) tracking of latently infected cells, (2) conditional ablation of viral peptide processing in selected cell types. The results of this action are expected to improve our understanding of the mechanisms and requirements for MI, laying the basis for the development of improved vaccination strategies. Furthermore, identification of the sites of CMV latency in vivo will have implications for development of future clinical strategies aimed at harnessing the ability of CMV to reactivate in immune suppressed patients. Thus, this proposal explores a basic biological question of broad general interest, but also has robust translational potential for applications in human medicine.

Keywords: cytomegalovirus infection,cytomegalovirus latency,cytomegalovirus specific memory inflation,memory cd8 t cells,lymphoid organ stroma
Ownership, competition, innovation, and antitrust (OCIAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2023-06-30
Duration (months): 60.0
Total project cost (EUR): 1071947.5
EU funding (EUR): 1071947.0
Participants: 1
Project status: SIGNED

The project intends to study the effect of the ownership structure of firms on competition in product markets, innovation, and aggregate outcomes, and derive welfare and policy implications. The rise of institutional investment, with the profound changes occurred in the asset management industry in the last decades, has implied important variations in the ownership structure of firms. Among them, there has been a formidable increase in common ownership of firms in the same industry, which has raised antitrust concerns, mostly in the US but also in the EU. At the same time, a lack of dynamism in terms of entry and exit, investment and innovation, linked to potential secular stagnation of advanced economies, has been perceived, and blamed on the rise of market power. The proposed research will develop mostly theoretical models to study the effects of changes in the investment industry and firms’ ownership patterns on product markets and the general equilibrium macroeconomic consequences. The proposal consists of five strands. The first three purport to study the effect of changes of the market structure of the investment industry and ownership structure of firms on: i) market power in product markets; ii) investment and innovation incentives in the presence of technological spillovers among firms; and iii) aggregate output, investment, labour supply and income distribution. The fourth strand aims to develop empirical assessments of the developed theory. The final strand of the proposal will derive the antitrust and regulatory implications of the results. Particular attention will be devoted to the impact of changes in the network of control rights and cash flow rights of firms’ owners. The novelty of the approach lies in the integration of the perspectives and tools of industrial organization, corporate finance, and network theory to provide a global view of the relationship between ownership structure, competition and innovation.

Keywords: minority shareholdings,corporate governance,networks,investment,randd,spillovers,collusion,competition policy
Mannan-related enzymes of wheat endosperm (MANAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

European society and economy relies on the productivity of staple food, such as wheat. Plant cell walls are a centrepiece of plant development and tuning their biosynthesis could improve the productivity and the quality of wheat grain. Although the structure of cell wall polysaccharides is relatively well-documented, little is known about their biosynthesis. The project proposes for the first time 1) to explore the structure, organisation and function of mannan, a cell wall polysaccharide that impacts on wheat grain development, and 2) to investigate the function of four putative genes involved in the mannan biosynthesis, using a combination of well established and new methodologies (enzymatic fingerprinting, FT-IR microspectroscopy and MALDI-MS imaging). This research is of potential interest to various industrial sectors (e.g., plant breeding, milling and biofuel industries) active in Europe and represents a good opportunity to improve competitiveness of European agriculture. Within the host institute (INRA, France), which is a World leader for agricultural sciences, the supervisor is internationally renowned for its contribution in the general understanding of plant cell walls. The host will offer the opportunity to the fellow to develop a sound knowledge in biochemistry and molecular biology and will contribute to improve his managerial skills. In return, the fellow who has a strong expertise in microscopy and enzymatic activity assays will implement these techniques in the host institution. The fellow will have the opportunity to disseminate his knowledge during various events towards audiences of scientists, students and the general public. The fellow will access to all the facilities, logistics, and equipment necessary for the good implementation of his project. In summary, this innovative project will contribute to European excellence and will offer the training the fellow needs to pursue his career as an independent principal investigator in plant science.

Keywords: plant cell wall glycosyltransferase wheat polysaccharide
Socialising Sensori-Motor Contingencies (socSMCs)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Germany,Sweden,United Kingdom
Call: Knowing, doing, being: cognition beyond problem solving (H2020-FETPROACT-2014, 2014)
Start date: 2015-01-01
End date: 2019-09-30
Duration (months): 57.0
Total project cost (EUR): 3778125.0
EU funding (EUR): 3778125.0
Participants: 9
Project status: CLOSED

As robots become more omnipresent in our society, we are facing the challenge of making them more socially competent. However, in order to safely and meaningfully cooperate with humans, robots must be able to interact in ways that humans find intuitive and understandable. Addressing this challenge, we propose a novel approach for understanding and modelling social behaviour and implementing social coupling in robots. Our approach presents a radical departure from the classical view of social cognition as mind-reading, mentalising or maintaining internal rep-resentations of other agents. This project is based on the view that even complex modes of social interaction are grounded in basic sensorimotor interaction patterns. SensoriMotor Contingencies (SMCs) are known to be highly relevant in cognition. Our key hypothesis is that learning and mastery of action-effect contingencies are also critical to enable effective coupling of agents in social contexts. We use “socSMCs” as a shorthand for such socially rele-vant action-effect contingencies. We will investigate socSMCs in human-human and human-robot social interaction scenarios. The main objectives of the project are to elaborate and investigate the concept of socSMCs in terms of information-theoretic and neurocomputational models, to deploy them in the control of humanoid robots (PR2, REEM-C) for social entrainment with humans, to elucidate the mechanisms for sustaining and exercising socSMCs in the human brain, to study their breakdown in patients with autism spectrum disorders, and to benchmark the socSMCs approach in several demonstrator scenarios. Our long term vision is to realize a new socially competent robot technology grounded in novel insights into mechanisms of functional and dysfunctional social behavior, and to test novel aspects and strategies for human-robot interaction and cooperation that can be applied in a multitude of assistive roles relying on highly compact computational solutions.

Keywords: implicit social cognition,embodied social interaction,dynamic agent coupling,shared action,we mode,social emotions,interactionism
Generalized bin picking system for automatic handling of unsorted parts in industrial applications (BINPICKING 3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project is based on developing a generic and universal bin picking solution enabling industrial robots to see,find and grip components randomly placed in bins.In contrast to traditional approaches,our innovative approach boosts the perception performance to a manufacturing level by locating the sensor in the robot’s gripper.The technical innovative aspects of this solution comprise:Use of intelligent and adaptive exploration trajectories;Use of hundreds of images of the scene;Estimation of robot encoders permitting a robot independent solution Our universal bin picking solution (for any robot and any part) will cover Spanish’s 3% market in the first 2 years and gradually extend its coverage to Europe.We have signed two strategic alliances with two world’s leading robot manufacturers to jointly provide bin picking solutions.This is due to the universality of our bin picking solution Robot cell builders are our primary customers since they manufacture automated lines.The current lack of a reliable competitive bin picking solution implies that robot cell builders must develop their own custom solutions,which is not always possible since it requires of highly skilled computer vision abilities.Our product will be crucial for robot cell builders to spot new robot cell users generating new markets and solving customer needs Our goal is to bring our universal bin picking solution from its present TRL6 demonstrator to TRL9 competitive in manufacturing ready to market product.SME instrument phase 1 aims to determine the technological,practical and economic viability of our business idea,together with the resources needed to implement it.This study must assure the success of the business idea.The financial needs to achieve a final TRL9 product (phase 2) are 1.5M€ We expect to develop TRL7/TRL8 demonstrators in 2016 and 2017 in the Spanish market jumping to Europe in 2018 with an estimated market size of ~3.500 bin picking units and a forecasted penetration of 2%-3%

Keywords: bin picking,3d vision,machine vision,robot vision,object recognition
Variation on a theme: evolutionary-developmental insights into the Asteraceae flower head (CAPITULA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Plant reproduction relies on flowers and their arrangement into inflorescence –two interrelated traits that exhibit impressive variation between plant lineages and constrain crop yields and horticultural forms. A key aim in evolutionary biology is to unravel how the modification of genetic networks has led to the diversification of reproductive plant architecture and floral form. This project addresses this aim by seeking to understand how two fundamental biological processes, floral architecture and symmetry, have evolved in the daisy family Asteraceae, with unique combinations of these traits. Much of the research on Asteraceae has concentrated on model plant systems with simple heterogamous capitula (e.g. gerbera, sunflower). We propose an original and novel evolutionary-developmental (evo-devo) approach to floral evolution, by bringing to this field the species of Asteraceae with secondary heads (=syncephalia). This unique capitulum architecture has arisen from two rounds of capitulescence (i.e. inflorescence condensation followed by simplification) during their evolution. Syncephalous species which comprise ca. 70 genera from 11 tribes provide an invaluable source of material for deciphering the genetic basis of capitulum evolution since their genomes bear the signature of two inflorescence shifts toward capitulescence. Our approach, integrating the most recent experimental and theoretical developments in evo-devo and genomics fields, provides a unique opportunity to ask fundamental questions relating to coordinated trait evolution, and to increase our understanding of how genetic pathways have been altered or co-opted during the evolutionary diversification of flowers. The knowledge gained has the potential to open up novel molecular breeding strategies for developing improved varieties of horticultural and crop plants in this family of great economical importance (e.g. artichoke, chrysanthemum, gerbera, knapweeds, lettuce, sunflower).

Keywords: floral and inflorescence structures,genetic pathways,polyploidisation,asteraceae
Venom Evolution in Nemerteans: Connecting Functional Morphology, Gene Expression and Proteome through Spatial Omics (Finding VENomS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-10-02
Duration (months): 24.0
Total project cost (EUR): 209612.01
EU funding (EUR): 209612.01
Participants: 2
Project status: CLOSED

Animal venoms are key adaptations that have evolved independently in many taxa to assist in defence, predation and competition. Venoms are some of the most complex biochemical secretions known in nature, but despite this complexity, there is a high degree of convergence in toxin structure and targets, making venomous organisms great model systems to investigate areas as diverse as molecular evolution, functional convergence and drug discovery. However, the processes underlying toxin and venom evolution remain poorly understood, particularly in invertebrates. With recent advancements in sequencing and analytical techniques these neglected taxa are being increasingly investigated, revealing a high genetic and functional diversity of venom compounds and challenging traditional views about venom evolution. Still, many phyla such as ribbon worms (Nemertea), active predators that use toxins for defense and predation, remain understudied. This project aims to investigate venom evolution in Nemertea using an integrative evolutionary venomics approach. I propose to use a transcriptomics-proteomics approach referred to as proteogenomics, combining RNA-seq differential gene expression analysis (DGE) and tandem mass spectrometry-based proteomics (MS/MS) to determine venom composition, and integrate these data with expression and functional morphology data derived from spatial omics, both spatial transcriptomics (ST) and spatial proteomics (MALDI-IMS), transmission and scanning electron microscopy (TEM and SEM). This will advance our understanding of ribbon worm venom systems, and shed new light into the true diversity of animal venoms and their evolution. Additionally, this research will likely uncover novel bioactive compounds, with great potential as drug leads and biotechnological tools, making this project’s findings highly relevant to the H2020 focus area Blue Growth objective of developing new bio-based products, including pharmaceuticals.

Keywords: rna seq,gene expression,transcriptomics,proteomics,proteogenomics,spatial transcriptomics,maldi ims,venomics,venom,toxins,ribbon worms,nemerteans,nemertea
Innovation activity to develop technologies to enable a pan-European interoperable broadband mobile system for PPDR, validated by sustainable testing facilities (BroadWay)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Enhance stadardisation and interoperability of systems, including for emergency purposes
Action type: Pre-Commercial Procurement
Countries involved: Estonia,Germany,Germany,Spain,Ireland,Italy,Belgium,Finland,Romania,Greece,France,Czechia,Netherlands,United Kingdom
Call: Broadband communication systems (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-05-01
End date: 2023-01-31
Duration (months): 57.0
Total project cost (EUR): 13131438.56
EU funding (EUR): 11818294.7
Participants: 20
Project status: SIGNED

The BroadWay project will take the first procurement steps to enable ‘interoperable next generation of broadband radio communication systems for public safety and security’ to improve Public Safety and Disaster relief organisation’s (PPDR’s) service to Europe’s citizens, and enhance interoperability across borders. The primary goal of this project is to: ‘Procure Innovation activity to develop and demonstrate TRL8 technologies that will enable a pan-European interoperable broadband mobile system for PPDR, validated by sustainable testing facilities’ This project implements a Pre-Commercial Procurement (PCP) with the purpose to realise innovative solutions for the implementation of the ‘SpiceNet Reference’ architecture as defined by the BroadMap project. A pan-European pilot system will be developed within the timeframe 2021, validated by sustainable test capabilities, and to the satisfaction of a European wide team of public safety practitioners. The BroadWay partnership is comprised of 11 buyers in 11 countries, who represent the organisations with responsibility for transition to broadband for Public Safety Communication within their country. All buyer partners are from EU member states. 4 are the direct responsible Ministry within their country, and 7 are the delegated authority in their country, responsible to operate public safety communication networks. Our buyers represent the operation of public safety communication for 1.4Million public safety practitioners in their respective countries. 49 practitioner organisations from a total of 19 countries have offered to take part in the pilot validation/evaluation activities as members of our Practitioner team. A total of 60 additional organisations have expressed their support for the BroadWay project. The BroadWay team, plus this additional support, covers a total of 23 European Countries with 7 additional countries represented by their ministries responsible for public safety communication.

Keywords: public safety communication,mobile broadband,mission critical