Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbiome Based Therapeutics for Cancer Immunotherapy (BMC128)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Immune-Checkpoint inhibitors (ICI) have transformed treatment of solid tumors, specifically in cutaneous melanoma, clear cell renal cell carcinoma (ccRCC) and non-small cell lung cancer (NSCLC). Despite advancements, resistance to ICI eventually occurs in many patients, leading to limited survival rates. Depending on the indication, 40-80% of patients fail to respond to ICI therapy, highlighting the need for innovative therapies. Recent reports found patients showing poor response to ICI are characterized by reduced gut microbiome diversity, suggesting the gut microbiome’s role in immune activation and ICI response. No microbiome-based cancer drugs are approved yet, though several are in the pipeline. Leveraging Biomica's Computational Predictive Biology platform that enables high-resolution functional microbiome analysis, BMC128 was developed: a rationally designed live bacterial consortium of four microbial strains, designed to induce anti-tumor immune function in conjunction with ICI. Strains were identified by analysing microbiome & clinical data from cancer patients. In pre-clinical studies, treatment with BMC128 potentiated the ICI efficacy in various models, reducing tumor volume, raising the number of responders, and demonstrating an increase in infiltrating immune cells. BMC128 has shown positive preliminary results in First-in-Human trials in combination with nivolumab, an anti-PD1 ICI, in patients with NSCLC, melanoma, and ccRCC. BMC128 offers superior reproducibility and safety as well as a well-controlled manufacturing process. We project market share of 22% 5 years post product launch in 2030, which presents a SOM of €3.1B. In the EIC project, we will conduct a phase 2 study in the EU and US with 70 participants with prior resistance to ICI therapy. The primary goal is to establish BMC128’s clinical benefit rate based on complete or partial response, or at least 24 weeks of stable disease using the Response Evaluation criteria in Solid Tumors criteria.

Keywords: rationally designed live bacterial consortium,cancer immunotherapy,microbiome pharmaceuticals,computational predictive biology platform,improved clinical outcomes
Microbiome Identification and Application with SPARK-biomSCAN (SPARK-MIDAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

SPARK-MIDAS is focused on the critical challenge of organism identification, integrating Next-Gen Sequencing, custom molecular probes and bioinformatics algorithms to revolutionize diagnostic solutions across diverse applications, from healthcare to agriculture. The microbiome is incredibly diverse and encompasses a countless variety of organisms, including millions of viruses, bacteria, parasites, insects, and even large animals. Microbiome identification is applicable for: 1) patient care through precise, personalized treatment plans, benefiting doctors, dietitians, and veterinarians; 2) researchers, by simplifying complex methodologies, enabling a focus on groundbreaking discoveries, and 3) industries by enabling rigorous product testing and validation, ensuring consumer safety in food, probiotics, cosmetics, and feed. The demand for microbiome sequencing services is accelerating, reflecting in the market's expanding valuation. This growth is propelled by the increasing recognition of microbiomes' role in health, disease, and environmental processes, coupled with technological advancements in sequencing and data analysis. The microbiome sequencing market, is expected to grow: from USD 1.26 billion in 2021 to USD 3.13 billion by 2030 at a 10.7% Compound Annual Growth Rate (CAGR) by SKYQUEST- or from USD 1.5 billion in 2022 to USD 6.7 billion by 2032 at a 18% CAGR - by,MARKET RESEARCH FUTURE. SPARK-MIDAS addresses the urgent need for broad, accurate, rapid and affordable microbiome identification methods. The goal of the project, is to expand and globally disseminate microbiological diagnostics in the European and global markets, based on continuous development of the SPARK-biomSCAN test. Service is already available for clinical, veterinary, and R&D at Spark-Tech clinical laboratory. This comprehensive application spectrum underscores project contribution to advancing health, agriculture, and environmental sustainability.

Keywords: microbiome,next gen sequencing,bioinformatics,microbiological diagnostics,microbiome sequencing,healthcare,agriculture
Collaborative Open Platform for PILOTing services across energing smart IoT and Edge computing environments (COP-PILOT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Innovation actions
Countries involved: Luxembourg,Greece,United Kingdom,Portugal,Cyprus,Germany,Ireland,Netherlands,Sweden,Spain,Italy,Switzerland
Call: Piloting emerging Smart IoT Platforms and decentralized intelligence (IA) (HORIZON-CL4-2024-DATA-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 27710415.0
EU funding (EUR): 22499384.25
Participants: 47
Project status: SIGNED

The integration of edge computing, advanced 5G connectivity, and decentralized processing drives the widespread deployment of private edge ecosystems capable to reshape numerous industry sectors. However, unlocking the full potentials of edge-level intelligent management requires concerted efforts in platform development and cross-sector collaboration. COP-PILOT, develops a Collaborative Open Platform framework geared towards orchestrating end-to-end services across diverse industry domains. In crafting an open platform, COP-PILOT provides a flexible solution designed to effectively manage various industry sectors while ensuring robust security, automation, and intelligence features. Regarding interoperability, the framework seamlessly integrates with underlying technologies, ranging from IoT platforms to core infrastructure, facilitating collaboration across the compute continuum. Furthermore, COP-PILOT empowers the development of advanced cross-sector applications by offering support for cutting-edge network services, thereby enabling heightened security, resource management, and automation capabilities. The implementation strategy revolves around two primary directions: enabling platform implementation and real environment integration. For the former, COP-PILOT adopts a modular orchestration approach, simplifying the onboarding of complex applications through a user-friendly generative AI interface. This approach includes integration with multi-tiered data processing, policy-driven optimization, and dynamic reasoning capabilities, ensuring alignment with prevailing industry standards. In terms of real environment integration, the platform is deployed across four large piloting clusters, addressing a diverse array of edge paradigms. These use cases span across energy, smart city, agriculture, and industrial manufacturing sectors, fostering the development of cross-sector applications in mobility, logistics, and resource management.

Keywords: interoperability,validation blueprints,pilot manufacturing,open calls testbed,internet of things,smart buildings,agriculture,energy,mobility,logistics
GRAPHENE PHOTONIC FREQUENCY MIXER (GRAPH-X) (GRAPH-X-HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Spain
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 18.0
Total project cost (EUR): 459687.5
EU funding (EUR): 459687.5
Participants: 2
Project status: SIGNED

The objective of GRAPH-X is to develop a revolutionary hardware platform based on graphene-based Photonic Integrated Circuits (PICs) for use in the next generation of wireless communication technology. The project’s key component is a novel optoelectronic frequency mixer able to mix two optical wavelengths to access the D and WR4 frequency bands (from 110 to 260 GHz) in order to provide a solution for ultra-high speed and scalable sub-THz wireless links. The successful development of this technology has the potential to revolutionize the telecommunications industry, enabling faster and more reliable communication, which will facilitate the growth of emerging technologies such as 6G. In this context, the ability to generate those optical wavelengths with high-quality, tunability, and broad bandwidth capabilities in a compact form factor becomes a highly interesting opportunity that aligns well with the main goal of the project. The addition of ARC as a new partner, with wide expertise in developing miniaturized solutions for sub-THz generation, is expected to significantly enhance the GRAPH-X's objectives. We will develop a new miniaturized architecture on a photonic chip for the generation of sub-THz signals based on photonic techniques such as Optical Frequency Combs (OFC) and advanced filtering mechanisms that leverage on-chip laser devices. The system's interest lies in the fact that it combines the advantages of both electronic and photonic approaches for the generation of optical wavelengths that could readily synthesize sub-THz waves, giving rise to a new generation of systems with all the aforementioned characteristics. Furthermore, the architecture will be designed and implemented using PIC technology with the objective of offering a smaller size and lower power consumption while also addressing problems beyond the reach of traditional bulk, tabletop photonics.

Keywords: photonic integration,photonic integrated circuits,graphene photonic devices,electronic and photonic integrated circuits,sub thz links
Porous poly(ionic liquid)s for CO2 capture and simultaneous conversion under ambient conditions (PARIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1999444.0
EU funding (EUR): 1999444.0
Participants: 1
Project status: SIGNED

CO2 capture, storage and utilization is judged critical to mitigate the rapid rise in the atmospheric CO2 concentration. A key problem is the gigantic mass of CO2 emitted, which asks for robust, efficient and economically viable approaches that are currently missing and limited by the lack of suitable materials. To break through this barrier, I aim to develop metal-free dual-function porous poly(ionic liquid)s (DPPs) to capture and convert CO2 under ambient conditions into cyclic carbonates with high efficiency, and to apply them in model reactors for cost-effective processing of CO2. Poly(ionic liquid)s (PILs) are innovative ionic materials, in which ionic liquids (ILs) are covalently joined by a macromolecular backbone. ILs are known CO2-philes, and IL-derived PILs are naturally in favour of CO2 sorption, while their ions can be tailor-made for catalytic CO2 transformation. Such dual-function as sorbent and catalyst is the intrinsic merit of PILs to address the CO2 challenge, but unfortunately has been long impeded by the mismatched chemical structures in each function. Our preliminary work proved that the newly emerging 1,2,4-triazolium PILs were catalytic active and drastically more CO2-philic than common polyimidazoliums, and are believed as the game-changer materials. We envision that by structuring chemically tailor-made 1,2,4-triazolium PILs into highly porous materials, they will be able to capture and convert CO2 under ambient conditions. This ground-breaking materials concept will circumvent the complicated, harsh conditions for CO2 fixation, and cut the cost to an affordably low level. This project will radically advance scientific knowledge and technology to fixate and convert CO2 at scale into value-added chemicals that further reduces the consumption of fossil resources. Its outcome will expedite the research in PIL and dual-function materials to revolutionize the CCU routes and equip us with powerful materials tools to mitigate the global CO2 rise.

Keywords: poly ionic liquid,co2 capture and utilization
Pollinator-assisted plant natural selection and breeding under climate change pressure (DARkWIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,France
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 2911722.5
EU funding (EUR): 2911722.5
Participants: 5
Project status: SIGNED

Food security is threatened by climate change, with heat and drought being the main stresses affecting crop physiology and ecosystem services, such as plant-pollinator interactions. Despite the increasing relevance of flowers in sensing the stress, phenotyping platforms aim at identifying genetic traits of resilience by assessing the physiological status of the plants, usually through remote sensing-assisted vegetative indexes, but find strong bottlenecks in quantifying flower traits and in accurate genotype-to-phenotype prediction. However, as the transport of photoassimilates from leaves (sources) to flowers (sinks) is reduced in low-resilient plants, flowers are better indicators than leaves of plant well-being. Indeed, the chemical composition of flowers changes in response to heat and drought, as it does the amount of pollen and nectar that flowers produce, which ultimately serve as food recourses for the pollinators. DARkWIN proposes to track and rank pollinators’ preferences for flowers of a tomato mapping population exposed to heat and drought as a measure of functional source-to-sink relationships. To achieve this goal, DARkWIN will develop a pollinator-assisted selection and phenotyping platform for automated quantification of Genotype x Pollinator x Environment interactions through a bumblebee geo-positioning system. Pollinator-assisted selection for agriculture will be validated by a multi-omics dataset of unprecedented dimensions in a mapping population of tomato, including floral metabolic, transcriptomic, and ionomic traits, as well as mapping candidate genes, linking floral traits, pollinator preferences, and plant resilience. Moreover, DARkWIN will deliver tomato F1 pre-commercial varieties based on the natural biological process of pollinatordriven selection under climate change conditions. This radical new approach can change the current paradigm of plant phenotyping and find new paths for crop breeding assisted by ecological decisions.

Keywords: plant breeding plant phenotyping stress resilience geo positioning plant x pollinator x environment flower metabolism natural selection multi omics ecosystem services source sink relations
Interplay of Blending and Interfacial Zones in Sustainable Recycled Asphalt Materials: A Comprehensive Mechanical Characterization and Modeling Study (BIZ-SRAMCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 3
Project status: SIGNED

The "Interplay of Blending and Interfacial Zones in Sustainable Recycled Asphalt Materials: A Comprehensive Mechanical Characterization and Modeling Study" (BIZ-SRAMCS) aims to equip a promising young researcher, Dr. Yi Li, with advanced skills in interdisciplinary research. This project endeavors to advance the sustainability of Recycled Asphalt Materials (RAMs) by enabling precise durability predictions through comprehensive microstructural and mechanical characterization of the Blending Zone (BZ) and Interfacial Transition Zone (ITZ). The main research objectives include 1) a profound understanding of RAMs' microstructure, 2) enhanced lab assessment and modeling approaches for the mechanical behavior of BZ and ITZ, and 3) the development of an accurate numerical tool for predicting the response and cracking behaviors of RAMs. This work, carried out in collaboration with TU Delft, RWTH, and TotalEnergies, is poised to strengthen the EU's scientific and industrial leadership in RAM innovation. Moreover, BIZ-SRAMCS will provide Dr. Yi Li with a broad spectrum of learning opportunities, including project management, intellectual property rights, and teaching and supervising. Under the mentorship of Dr. Liu, an experienced scientist at TU Delft, the Fellow will gain diverse knowledge and skills, setting the stage for a successful career as an independent researcher in sustainable infrastructure.

Keywords: road infrastructure recycled asphalt materials blending zone interfacial transition zone advanced numerical tool
Deciphering the molecular mechanisms of Ectopic pregnancy using Transcriptomics and Exploring Cellular Trophoblast invasion (DETECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Ectopic pregnancy affects ~2% of pregnancies and is the leading cause of death in the first trimester. It occurs when the embryo implants outside the uterus, often in the fallopian tube. Placentation, a critical process for pregnancy success, is severely disrupted in ectopic pregnancy. The dysregulated trophoblast invasion in an unsuitable environment can lead to tissue rupture and life-threatening maternal bleeding. Despite its severity, the molecular mechanisms underlying placentation and its dysregulation in ectopic pregnancy are poorly understood. This proposal aims to uncover these mechanisms by combining cutting-edge transcriptomics technologies and computational methods. The project involves three main objectives: [1] Generate the first single-cell and spatial transcriptome atlas of ectopic pregnancy, profiling uterine and fallopian tube samples from donors with typical (eutopic) and ectopic pregnancies between 5-8 post-conceptional weeks. [2] Develop a novel computational framework, MultiCell, to identify differences between eutopic and ectopic pregnancies in molecular mechanisms supporting trophoblast invasion, integrating cellular metabolism, cell-cell communication, and signaling. [3] Validate the effect of identified molecules on trophoblast invasion using trophoblast organoid models. By comprehensively profiling cell types and their spatial organization in both conditions, and developing new computational tools to analyze these data, this research will provide unprecedented insights into the molecular basis of placentation and trophoblast invasion in eutopic and ectopic pregnancies. The project's findings could lead to improved preventive tools and treatments in multiple pregnancy complications where trophoblast invasion is dysregulated, contributing to reducing the incidence of this life-threatening condition and advancing our understanding of the female reproductive system and early pregnancy.

Keywords: ectopic pregnancy first trimester pregnancy placentation trophoblast invasion single cell transcriptomics spatial transcriptomics bioinformatics cell cell communication signaling metabolism
CitiObs – Enhancing Citizen Observatories for healthy, sustainable, resilient and inclusive cities (CitiObs)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Norway,Ukraine,Netherlands,Ireland,Greece,Belgium,Spain,Poland,Germany,France
Call: Uptake and validation of citizen observations to complement authoritative measurement within the urban environment and boost related citizen engagement (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5272950.0
EU funding (EUR): 4991205.0
Participants: 16
Project status: SIGNED

CitiObs will consolidate and apply tools and practice-based knowledge for co-creating data, knowledge and local action via Citizen Observatories (COs): these tools will enhance existing and new citizen observatories to engage citizens and marginalised communities, add value to environmental observations in the urban context, increase and validate citizen observations of the urban environment as part of the existing in-situ Earth Observation systems, co-create inclusive local actions for sustainability and ensure that CO data contributes to research and policy development towards the objectives of the European Green Deal. To ensure broad use, the CitiObs tools and approaches will be developed in co-creation with COs in 5 Frontrunner cities, finetuned with 30 Implementer cities and showcased to 50 Fellow cities. The pressure on cities to speed up the process of emissions reduction from pollutants and climate gases is overwhelming. The required measures are likely to be found not only in technological development but also in the required social transformations. Theseis transformations includes increasing citizen involvement and engagement with science and policy, increasing awareness of the underlying issues and promoting societal actions to protect the urban environment. Technological innovations need to be considered within the context of multi-level vertical and horizontal governance structures where citizen participation is recognized and included. CitiObs will support citizen observatories in distinct cities to create/enhance/or scale up inclusive and diverse citizen observatories, fostering in particular an active role of citizens in the observation of the urban environment using low-cost sensor technologies and wearables, with a particular focus on air quality and related environmental measures. CitiObs will formalise, valorise and legitimise the role of citizen observations.

Keywords: citizen observatories urban environment citizen science socio technological approach co creation