Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
History of the Tocharian Texts of the Pelliot Collection (HisTochText)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-03-31
Duration (months): 66.0
Total project cost (EUR): 1833103.0
EU funding (EUR): 1833103.0
Participants: 1
Project status: SIGNED

HisTochText addresses written Buddhist culture of the northern Silk Road in an innovative and path-breaking way, by going beyond the frontier of disciplines which have been cultivated separately: philology, digital humanities and in-depth analysis of materials, edition of Tocharian texts and comparative Buddhist literature, Sanskrit poetics and narratology, texts and social contexts. The flourishing Buddhist culture of the northern Silk Road during the 1st millennium CE in the Tarim Basin in present-day Xinjiang (NW China) is known by archaeological findings, artifacts and manuscripts in various languages. Since Buddhism was introduced from India, Sanskrit was the dominant religious language. By contrast, Tocharian belongs to the few local languages that are known to us thanks to Buddhist written culture. The two closely related Tocharian languages (Tocharian A and Tocharian B) were deciphered in 1908 on the basis of manuscripts discovered at the beginning of the past century in Buddhist sites of this region, together with Sanskrit manuscripts. The collection of the Bibliothèque nationale de France issued from the Pelliot expedition is a major collection of Tocharian manuscripts, counting around 2,000 fragments, second only to the Berlin collection, but in comparison hardly investigated, despite its containing numerous unique masterpieces and the broadest cross-section of manuscript and document styles and types. Only one fourth has been edited, mostly in a provisional manner, without translation nor commentary. Many texts of the Pelliot collection, literary and non-literary, are of the utmost importance because they have no match in any other collection of Tocharian manuscripts, nor in Buddhist corpora in other languages. As most Pelliot manuscripts in Sanskrit and in Tocharian were found in Buddhist sites of the Kucha region, the comprehensive edition and analysis of the texts will provide precious information about an important centre of Central Asian Buddhism.
Multiphoton Microscopy and Ultrafast Spectroscopy: Imaging meets Quantum (MUSIQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Germany,Spain,Germany,Germany,Lithuania,Switzerland,France,Netherlands,Netherlands,Luxembourg,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 4034446.92
EU funding (EUR): 4034446.92
Participants: 16
Project status: SIGNED

In the quest to decipher the chain of life from molecules to cells, the biophysical questions being asked increasingly demand techniques that are capable of identifying specific biomolecules in their native environment at the smallest possible scale, and measuring their interactions quantitatively without perturbing the system under observation. Laser-based optical microscopy is a key technology to drive this progress in the 21st century. Still, many challenges remain in particular toward i) achieving imaging with biomolecular specificity without the artefacts from sample staining, ii) quantitative imaging, and iii) single molecule sensitivity. Progress toward biomolecular specificity at very high temporal resolution has been brought by the development of ultrafast two-dimensional electronic spectroscopy, able to address the importance of quantum coherences with the potential to unravel the fundamental machinery of Nature. Yet, measuring quantum phenomena with an optical microscope is technically challenging, and far from real-world biological applications. MUSIQ is designed as an innovative research and training network, where we will recruit 15 Early Stage Researchers to work toward the central ambitious goal of developing the next-generation optical microscopy exploiting quantum coherent nonlinear phenomena. The network brings together a unique team of 7 world-leading academics and 6 high tech companies at the forefront of optical microscopy and ultrafast laser technology developments merged with fundamental understanding of coherent light-matter interaction phenomena, development of quantitative image analysis tools, and biomedical/pharmaceutical real-world applications. MUSIQ will establish an intersectoral training and research programme at the physics/chemistry/life science interface with partners from 9 European countries, aimed at creating the next generation of skilled well-connected scientists that will pioneer the ‘quantum microscopes of tomorrow’.

Keywords: optical microscopy,nonlinear optics,ultrafast spectroscopy,biophotonics,nanophotonics,coherent light matter interaction,vibrational microscopy,plasmonics
Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation (CANCERPREV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Italy,Switzerland,Finland,Sweden,Belgium
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-02-29
Duration (months): 52.0
Total project cost (EUR): 4096014.48
EU funding (EUR): 4096014.48
Participants: 7
Project status: SIGNED

Incidence and prevalence of many cancer types are significantly increasing worldwide, with substantial differences between the sexes. Environmental influences in concert with genetic and epigenetic factors are still poorly understood. Simultaneously, more sophisticated and expensive treatments cannot be afforded by society, increasing urgency of efforts in cancer prevention. CANCERPREV is an innovative interdisciplinary research and training program gathering seven academic beneficiaries and nine partner organizations : (one leading pharmaceutical company, one leading technology company, a health insurance, an internationally known nursing school, three foundations and two universities) in nine European countries. CANCERPREV aims to establish new strategies in cancer prevention, with a focus on two key determinants of cancer risk: sex hormone signaling and chronic inflammation, in breast and skin as benchmarks of early steps of cancer development in organs with reproductive and non-reproductive functions, respectively. Fifteen Early Stage Researchers (ESRs) will benefit from the complementary expertise of participating organizations and Principal Investigators in: basic cancer research, xenografts and genetic mouse models, bioinformatics and mathematical algorithms, epidemiology / human genetics, biomarkers, pharmacological approaches, behavioral / societal issues and outreach. This network provides ESRs with unique future career opportunities in both academic and private sectors, through research training for PhD thesis projects with secondments and short and long visits to other participating research institutions, and yearly courses / formal lectures on various aspects of cancer prevention, including global health and occupational / behavioral issues. CANCERPREV will ensure that more knowledge and ideas are converted into products and services, and that a new generation of scientists is trained to contribute to the knowledge-based economy and society.

Keywords: cancer prevention,sex hormones,inflammation,tumor stroma,breast cancer,skin cancer,xenografts,mouse models,population genetics,biomarkers,drug development,epigenetics,gene regulation
Collaboration to develop a business plan for the Centre of Agriculture and Forestry (SMARTAgriFor)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Netherlands,Portugal,Portugal,Portugal,Portugal,Portugal,Portugal,Portugal
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 494515.0
EU funding (EUR): 494515.0
Participants: 13
Project status: CLOSED

The Portuguese national funding agency for Science and Technology - Fundação para a Ciência e a Tecnologia - proposes an investment (>45 million Euros) whose ultimate objective is to develop a new centre of excellence on Smart Agriculture and Forestry (SMARTAgriFor) by teaming with the Wageningen University and Research Centre in a long-term sustainable partnership. This centre is to become an international reference in the field, with the critical mass of competence to engage Portugal strategically in a path of innovative growth and also for global impact. Due to the strategic importance and leverage value envisaged for SMARTAgriFor, there is already strong support from important stakeholders including regional development authorities ensuring access to European structural funds. Further, 10 universities and 1 public research institute – representing the top performing organizations in the selected scientific domain in Portugal - will support FCT by helping develop SMARTAgriFor’s business plan in collaboration with WUR. This plan will demonstrate the centre’s potential value as a radical new approach to the topics in question. Through dynamic interaction with stakeholders, strategic partnerships will be established, funding secured, and commitments formalised to transfer infrastructure/ staff in exchange for a share in its ownership, ensuring its sustainability and financial autonomy in the long run. Clear choices have been made regarding SMARTAgriFor’s scientific focus and innovation strategy. Topics have been selected for maximum positive societal, economic and scientific impact, leveraging strategic advantage from the centre’s location in Portugal. International benchmarking will identify the optimum approach for SMARTAgriFor. Further, innovative management practices will ensure feasible implementation. Further its innovative and impact focused RTD management will allow it to connect effectively at national and international level for the application of results.

Keywords: agriculture,forestry,centre of excellence
Increasing reproductive success in crops under high ambient temperature (REPROHEAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-12
End date: 2019-02-11
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

High ambient temperatures represent an obstacle for reproductive development in plants. Our own preliminary data indicate that mutations affecting auxin methylation facilitate pollen tube growth and confer increased reproductive capacity under higher temperatures in the model plant Arabidopsis thaliana. We propose to explore the benefit of reducing auxin methylation in temperature-sensitive crops like tomato and rice to maintain higher fruit/grain yields under heat and drought stress conditions. The research program includes field testing of new tomato varieties generated in this project, in conjunction with a crop company. The combined approach using CRISPR/Cas9 genome editing technology and chemical genetics, together with the thorough training program that we have devised, is targeted at complementing Dr. Resentini’s strong experience in plant molecular and cellular biology. By the end of the term, she will have an advantageous professional position at the interphase between Academy and European Industry.

Keywords: plant,temperature stress,plant hormone,tomato,reproductive development
Network Of practitioners For Emergency medicAl systems and cRitical care (NO FEAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Austria,Germany,Italy,Spain,Ireland,Israel,Ireland,Italy,Norway,Belgium,Romania,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Pan European Networks of practitioners and other actors in the field of security (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 3495957.5
EU funding (EUR): 3495957.5
Participants: 19
Project status: SIGNED

The emergency medical care in the EU is a fragmented chain including population, emergency medical services, volunteers, hospitals and cooperation with fire services, police and authorities. It needs to prepare to respond to new threats and assist casualties after security incidents. In response to this challenge, NO-FEAR proposes to bring together a pan-European network of practitioners, decision and policy makers in the medical and security fields. They will collaborate to achieve a common understanding of needs, as well as - in collaboration with academia and industries – increase the EU innovation potential that could better fill the operational gaps and recommend areas for future innovations. NO-FEAR main objectives are to: - create a long-lasting community of practitioners, interacting with a network of suppliers and academia, - elaborate an innovation roadmap, with practical recommendations for uptake, - advise relevant Research and Innovation projects, - support market uptake of EU research results, - issue policy and regulatory recommendations enabling collective procurement, - indicate priorities for standardisation; - support quick wins and practical short term results, - implement a transactional dynamic portal providing fora, a catalogue, market place and flexibility to address new threats. The project will be conducted by a consortium of 18 partners, of which 11 and the coordinator are practitioners, under the advice of the EC Community of Users. It aggregates the various dimensions of the project (acute care, operations and training), supported by the already large networks. To disseminate and exploit the NO-FEAR recommendations, an ambitious strategy will be implemented, including workshops, demonstrations and communication events every 6 months. This will enable knowledge sharing, build a common understanding and promote innovation uptake by organising technology showcases and demonstrations in a real practitioner environment.

Keywords: network of practitioners,emergency medical services,patients critical care,acute care operations,security incidents,new health threats,training,education,innovation uptake,project monitoring,standards
Tumor-Targeting Nanoengineered Bioorthogonal Technologies to Fight Metastatic Cancers (NANOBOTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-19
End date: 2020-11-18
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of the pioneers of the Bioorthogonal Organometallic Chemistry field. This will certainly promote the translation of the results and enhance my professional growth towards my research independence.

Keywords: nanotechnology,bioorthogonal catalysis,palladium activated prodrugs,chemotherapy,metastatic cancer
Negotiating gender across online and offline social spaces. A study of cyber-mediated gendered norms, practices and aspirations among women of Moroccan and Turkish descent in France and Germany. (CYBERGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-06-21
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The social landslide provoked by the #metoo movement demonstrated the transnational role of digital communication tools in major societal changes. At the same time, women of Muslim background face gendered forms of othering within media and popular discourses in Western Europe. Innovative research is needed to advance our understanding of how women shape gender norms and practices through appropriation and contestation across virtual and non-virtual spaces. Yet, no empirical study has focused on the post-migration generations with the combined lenses of gender and digital studies. CyberGen examines the everyday uses of digital spaces and social media by women of Moroccan and Turkish descent, in France and Germany, in relation to gendered norms, practices and aspirations through an original methodology combining a netnography (data mining of publicly available social media data) with ethnographic methods. CyberGen breaks new ground for understanding how gendered norms, attitudes and practices fluctuate across digital and non-digital social spaces. CyberGen objectives are (1) to conceptualise patterns of engagement with digital spaces by women of Turkish and Moroccan backgrounds in European contexts; (2) to advance our understanding of transnational and local dimensions of gendered digital engagements within post-migration communities; (3) to understand the articulation between the online circulation of gendered ideas and everyday practices through a doubly comparative case-study of two communities in two different national settings; (4) to produce original and timely data for academic and policy-making realms on gendered norms and attitudes allowing for the de-construction of essentialising accounts; and (5) to contribute to the development of the emerging field of digital migration studies by theorising gendered digital engagements and setting up a new research path. CyberGen promises to inform several EU programmes in the fields of integration and gender equality.

Keywords: post migration,gender equality,diversity,transnationalism
Immobilized proteins in porous materials – Structural studies by Pulse EPR dipolar spectroscopY (iSPY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Nature is by far the most versatile chemist and modern research efforts have harnessed the power of Nature by using biomolecules such as proteins as building blocks or targets for various technological applications. In many cases the immobilization of a protein in a synthetic matrix is essential. In particular protein-porous material hybrids have received much attention but their preparation have been non-trivial, often limited by the size compatibility between the pore and the protein and the surface properties. The quest for a suitable protein-matrix combination not only requires extensive synthetic optimization, but also the development of appropriate methodologies that can be used to determine the effect of the matrix on the structure and stability of the protein. In this multidisciplinary action, the stabilities, structures and dynamics of heme proteins (globins) immobilized in mesoporous silica or titania will be studied by EPR. This class of hybrid materials are themselves also of great interest because of potential electrochemical biosensing and biocatalysis applications. Novel orthogonally spin-labeled globins will be prepared and incorporated into (modified) mesoporous silica and titania. Pulse dipolar spectroscopy will be used to measure nanometric distance constraints within the free and immobilized globins. Combined with computational models, these measurements will provide unique insights into effects of incorporation on the tertiary structures and conformational flexibilities of the proteins. This action will not only result in the development of a generic analytical toolbox, based on spin-label EPR, for the characterization of proteins immobilized in matrices, but also lead to advances in the understanding and preparation of protein-porous material hybrids.

Keywords: electron paramagetic resonance