Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Long Way to a New Cosmology: Theories of Tides in Pre-Modern Thought (TIDES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

This project offers the first comprehensive study of pre-modern engagement with the relatively neglected yet highly problematic natural phenomenon of tides. It argues that the flow and ebb effect was an essential component of cosmological discussions in pre-modern Europe and attracted the attention of all major scholars whom we currently associate with the so-called Scientific Revolution. The competition amongst prominent thinkers involved in the study of astronomy and mathematics left its mark on a considerable number of works on tides, while the contesting solutions were believed to constitute a valid argument in favor of the respective cosmological theories. This also implies that the issue of determining the flow and ebb of water formed part of a larger discourse that went beyond strict mathematization of natural knowledge and reflected, on a more general level, a peculiar understanding of the cosmos and all it contains. Furthermore, the project makes an addition to a field of study that has been burgeoning in past years considering the current climate crisis. Several studies have recently devoted attention to pre-modern reflections on nature, especially with regard to various types of calamities. Despite not being considered a disaster because of their recurring and predictable character, tides were nonetheless seen as potentially devastating if not controlled and properly understood. Although inevitably put in relation with a discourse of the Flood, tidal accounts were largely devoid of metaphysical features, instead seeking out plausible mechanistic interpretations of the motion of water. At the same time, contrary to what has been suggested in scholarship, establishing the origin of tides was never regarded as a mere physico-mathematical exercise, but generally presented a matter of environmental concern. Thus, this project provides a synthetic account of pre-modern discourses of tides in their cosmological and environmental dimensions.

Keywords: history of science,renaissance and early modern intellectual history,astronomy and cosmology,environmental humanities,pre modern europe,mathematization of knowledge,natural philosophy
Illuminating body-brain communication channels at the choroid plexus and their impact on brain physiology. (BrainGate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1499514.0
EU funding (EUR): 1499514.0
Participants: 1
Project status: SIGNED

In contrast to other organs, the brain is surrounded by a system of specialized anatomical barriers isolating it from direct contact with immune cells and microbial products present in the blood. However, such factors do dynamically shape brain function in homeostasis and disease. Because of this unusual anatomy, the pathways of blood-brain communication are still poorly understood, while this understanding would provide a fundamental insight into brain function regulation, and enrich the current knowledge of neurological disease mechanisms. My previous work suggests that the choroid plexus (CP) is a central player mediating the influence of immune and microbial signals on the brain. The CP epithelium is a monolayer barrier tissue, which on the side facing the blood has the ability to sense such peripheral factors, and on the side facing the brain, produces the cerebrospinal fluid (CSF)–a liquid carrying nutrients and signaling molecules, which contacts nearly all brain cells, and ensures brain homeostasis. I therefore hypothesize that peripheral immune and microbial factors may shape brain function indirectly, via regulation of the CSF properties at the CP epithelium. Based on our preliminary data, and building on my past expertise in CP biology, neuroscience and immunogenomics, here I propose an interdisciplinary project BrainGate, striving to illuminate the physiological mechanisms and roles of gut-blood-CP-brain communication axis during post-natal development (Aim 1), under conditions of microbiota perturbation (Aim 2) and along the circadian cycles (Aim 3). By developing new tools for CP-specific genetic perturbation and combining them with approaches of spatial transcriptomics and behavioral readouts in mouse models, this project will reveal fundamental principles of physiological regulation of brain development, function and maintenance and pave the way for future investigation of the gut-blood-CP-brain communication circuit in neurological disease.

Keywords: choroid plexus,cerebrospinal fluid,behavior,immunogenomics,immune stromal interactions,
Just Central Banking (JUSTCB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

The recent financial crisis, and the ongoing ecological crisis, call for an urgent examination of the central banks’ place in society, both as a cause of harm and as a potential agent of justice. The central aim of this project is to determine what role central banks can play in the transition towards a more just and sustainable economy. First, this project will attempt to uncover what, if anything, is wrong with current central banking practices. The financial ethics literature is divided on whether their core problem is their lack of legitimacy, or their negative effects on justice and environmental sustainability. The first part of the project aims to show that all these problems stem from the unfair and inefficient division of political and epistemic labor between states, central banks, and commercial banks. Second, this project will delineate and defend potential reforms, which are able to improve the fairness and sustainability of central bank’s practices. The project will focus on new monetary policy instruments that central banks could use to target firms, banks, and citizens more directly. It will investigate how these policy tools can achieve a fairer balance of power between central banks, states, and commercial banks. In sum, by producing a unified theory that is able to account for the diversity of harms and benefits of central banking, this project aims to provide guidance on the ethical role of central banks and the necessary reforms of central banking.

Keywords: central banks,economic ethics,financial ethics,theories of justice,theories of legitimacy
Land use, Sustainability, and Democratic Backsliding (LUDEMO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2490723.0
EU funding (EUR): 2490723.0
Participants: 1
Project status: SIGNED

Land use and land systems, i.e. how human societies manage and interact with land through social-ecological systems, are at the core of sustainability issues. Democratic backsliding, i.e. the decline or degradation of the institutions and social norms that sustain democratic societies, is a widespread and impactful trend, with strong but understudied two-ways linkages with land use dynamics. In LUDEMO, we will make key contributions to understanding the linkages between these issues, with (i) explicit articulation and embedding of democratic backsliding concerns and knowledge within land system and sustainability science – moving beyond a focus of democratic backsliding research on social, economic and political aspects, and beyond a focus of sustainability science on policy rather than politics – ; (ii) spatial, quantitative causal analyses of linkages between multiple forms of democratic backsliding and land use changes and related environmental impacts – moving beyond mostly qualitative, political analyses – ; (iii) syntheses and theory building on these two-way interactions. We will investigate these issues through cross-country studies as well as the three focal cases of reactionary forces and agrarianism in Europe’s consolidated rural areas, extractive populism in Canada’s Northern frontiers, and agrarian authoritarianism in Mozambique’s smallholder landscapes.

Keywords: land system democracy social ecological systems earth observation
AI in Stroke Neurorehabilitation - Expansion and National Uptake in Romania (AISN-ENUR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Romania
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 35.0
Total project cost (EUR): 667937.5
EU funding (EUR): 599000.0
Participants: 2
Project status: SIGNED

The AISN Horizon Europe project will extend its consortium to include the Neuroscience Department of the Iuliu Hatieganu University of Medicine and Pharmacy (UMF) Cluj, scaling up the implementation and impact within the immediate and long-term scope. The action will enhance research and AI in Stroke Neurorehabilitation capacity at the medical facilities of Romania to accelerate the Romanian deployment of trustworthy AI-enhanced technologies in health services. Through the integration of Iuliu Hatieganu University of Medicine and Pharmacy into the AISN project consortium, the participating institutions will access large patient cohorts and legacy data to improve the reliability of the AISN digital twin and prognostics models; a broader set of medical facilities and target groups will be mobilized; and the validation of the impact of AISN technology in clinical decision-making will significantly expand. AISN-ENUR will develop a pilot neurorehabilitation ward adopting the full solution of AISN, representing a model in Romanian neurorehabilitation health facilities to be duplicated and expanded. The new widening partner will add tangible outputs related to their expertise in health economics, evidence-based tools for AI integration in clinical practice, and health policy and regulatory experience. The new team will develop a tool for economic evaluation to assess the viability and impact of interventions and an evidence-based clinical practice guideline to complement the operating procedures for implementing the AISN solution and uptaking it among clinicians. The project will establish the first European national adoption of AI in Stroke Neurorehabilitation through a collaborative framework developed with the national health authorities, local associations and Romanian stakeholders.

Keywords: health economics,clinical expansion guidelines,national adoption,cost effectiveness tools,patient cohort,legacy data
Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models. (EMPATIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cardiovascular diseases are the major cause of mortality worldwide, making the demand for new therapies an urgent need. Additionally, unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Such issues could be addressed by relevant in vitro human cardiac tissue models reproducing in vivo-like pharmacological response. However, most in vitro cardiac tissue models developed so far have been limited by complex design to enhance cardiomyocyte maturation, and poor ability to provide real-time functional assessment, making them poorly robust, reproducible, scalable and user-friendly. In EMPATIC I will overcome such limitations, through synergistic exploitation of biochemical and biophysical stimuli for cardiomyocyte phenotype maturation, studied in ERC project BIORECAR (772168). EMPATIC will provide a novel user-friendly and versatile multi-well plate platform for the in vitro modeling of mature functional human cardiac tissues and the non-invasive label-free monitoring of electrophysiological properties. EMPATIC platform will combine: (i) tailor-designed multi-well components, imparting biochemical and biophysical cues to in vitro cultured cells, and (ii) bioelectronic components enabling controlled electrical stimulation (ES) and biosensing. Collaboration with major experts in bioelectronics, cardiac regenerative medicine and electrophysiology, and companies will support EMPATIC innovation. My previous experience as coordinator of basic and applied research projects and co-founder of academic spin-off companies, and the entrepreneurship experience of 50% of EMPATIC team will support the process of technology development and validation.

Keywords: cardiac tissue models,in vitro testing,multi well platforms
Understanding kilonova diversity using radiative transfer simulations with realistic binary neutron star merger ejecta (KN-TRANSFER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

The merging of binary neutron stars produces an explosive kilonova transient, recently confirmed by the first ever detection of a kilonova, AT2017gfo, coincident with a gravitational wave signal, GW170817. The wealth of observations provided by AT2017gfo offers the opportunity to probe the fundamental physics of binary neutron star mergers, including the incompletely known Equation of State of dense nuclear matter and rapid neutron capture nucleosynthesis (the r-process), which produces half of all elements heavier than iron in the Universe. With the detection of AT2017gfo and the new gravitational wave observing run of LIGO, VIRGO and KAGRA (O4) the demand for kilonova simulations has never been so great. The aim of this research is to produce sophisticated, three-dimensional kilonova radiative transfer simulations from binary neutron star merger ejecta with detailed r-process calculations, allowing simulations to be directly compared to observations. I am uniquely placed to combine these complex simulations to self-consistently model kilonovae, enabling powerful constraints to be placed on the underlying physics through interpreting kilonova observations. I will carry out the first three-dimensional kilonova parameter space study based on realistic hydrodynamical neutron star merger simulations with a range of neutron star masses and Equations of State. The simulations will predict spectra using a state of the art line-by-line opacity treatment for millions of line transitions of r-process elements, which allows spectral features to be directly associated with the ions responsible for forming the features. This multi-disciplinary approach will constrain and improve hydrodynamical neutron star merger modelling, kilonova radiative transfer simulations, the high density Equation of State and r-process nucleosynthesis, which are critical to move our knowledge of kilonovae and their role in producing heavy elements in the Universe beyond the state of the art.

Keywords: kilonova,radiative transfer,spectral synthesis,binary neutron star mergers
INTEGRATE - Interdisciplinary Network for Training, Education, and Growing Research into Applications of and Therapeutic Expertise around Psychedelics (INTEGRATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Sweden,Czechia,Greece,Denmark,France,Portugal,Germany,Switzerland,United Kingdom,United States,Australia
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4300707.24
EU funding (EUR): 4300707.24
Participants: 34
Project status: SIGNED

Late-stage clinical trials show that psychedelic therapy (PT) has the potential to revolutionize mental disorder treatments, answering a huge and increasing unmet need. INTEGRATE is a multidisciplinary, multi-sectoral Doctoral Network (DN) for training and educating future leaders/experts in implementation of PT in society and healthcare. Four key challenges are identified: 1) The mechanisms of action of PT remain elusive, 2) Lack of clinical gold standards, 3) Legal, financial, and regulatory obstacles for PT access, and 4) Hype, hope, and ethical challenges. Through interdisciplinary research, training, and collaboration, INTEGRATE aims to advance psychedelic science, optimize treatment protocols, and address ethical and regulatory challenges to improve mental healthcare. It addresses the urgent need for well-trained experts to navigate the complex landscape of PT in healthcare. The project will train 16 Doctoral Candidates (DCs) to become T-shaped professionals, equipped with deep disciplinary knowledge and broad interdisciplinary skills. Through collaborative research, innovative training, and strategic secondments, INTEGRATE will tackle the key challenges in PT research with matching research and innovation objectives. The network brings together leading academic institutions, industry partners, and non-profit organizations across Europe, fostering a collaborative environment for advancing psychedelic science and improving mental healthcare.

Keywords: psychedelic therapy
Neural basis of rhythm categorization: how does the brain make sense of musical rhythm? (CATEGORHYTHM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

When we listen to music, recognizing a well-known rhythmic pattern and moving our body along seems like a natural and effortless task. Yet, these widespread human abilities are far from trivial, due to the sheer diversity and variability of possible rhythmic inputs that may stimulate our sensory organs. How does the brain categorize a particular sensory input as an instance of a particular rhythmic pattern? One view, which dates back to Darwin, is that rhythm categorization is driven by fixed mechanisms anchored in the ancient subcortical parts of the brain. However, recent behavioral research argues that categorical perception of rhythm is a complex flexible function, possibly relying on evolutionarily newer plastic cortical networks. The current project scrutinizes these views by combining an innovative methodological approach with high-resolution neuroimaging techniques (electroencephalography and magnetoencephalography). This novel approach will be used to unravel how different brain regions contribute to the transformation from faithful encoding of stimulus’ physical properties towards internal rhythmic categories. Moreover, neural categorization processes will be probed in participants with developmental dyslexia to assess their contribution to generalized rhythmic abilities, which are impaired in this population. The results are expected to provide key insights into the neurobiological mechanisms underlying perceptual categorization of rhythm, and their role in driving the universality, yet remarkable diversity of musical rhythms observed across cultures. Likewise, the outcomes of this project are expected to improve our understanding of the role of rhythm categorization processes in language development and its disorders, such as developmental dyslexia, with implications for the improvement of diagnostic and therapeutic tools.

Keywords: perceptual categorization,rhythm,music,meg,brainstem,cerebral cortex,frequency tagging,rsa