Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ex vivo Re-vascularization in Porcine Liver Bioengineering - A Critical First Step Towards Effective Transplantation of Bioengineered Livers (Liver Bioengineering)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Liver transplantation is currently the only proven therapy to extend life of patients with terminal liver disease. Organ bioengineering and regenerative medicine are promising new technologies that can help reduce the burden of liver shortage by increasing the number of organs available for transplantation. However, current bioengineered livers lack a functional vascular network that can readily allow their transplantation into a living host. Previous studies by the candidate have shown successful recellularization of acellular liver scaffolds using endothelial cells and hepatic cells in a perfusion bioreactor, creating a vascularized human liver organoid. However, its vascular network was unable to maintain vascular patency under constant blood flow for long periods of time. Hence, better understanding of how experimental cell seeding conditions of porcine liver scaffolds influence their re-vascularization efficiency is critical to achieve sustainable vascular patency after transplantation. In order to accomplish this, the impact of fluid flow pressure and the seeded cell number will be investigated in re-endothelialization efficiency of an acellular porcine liver scaffold. Furthermore, bioreactor pre-conditioning with fluid flow pressure ramping and sequential cycles of vascular growth and maturation will be used to induce re-vascularization, maturation, and enhanced function to potentially increase vascular patency. Finally, re-vascularized liver scaffolds will be transplanted into 5-10Kg pigs and short and long-term vascular patency will be investigated. Hence, the long-term objective of this project is to create a functional re-vascularized porcine liver scaffold, a critical first step towards the effective transplantation of bioengineered livers.

Keywords: organ bioengineering,decellularized liver scaffold,scaffold re vascularization,perfusion bioreactor,endothelial cells,pericytes
Centre for Europe-Brazil Business and Innovation Cooperation (CEBRABIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Austria,Spain,Germany,Germany,Türkiye,Belgium,Hungary,Brazil,Portugal
Call: Centres/Networks of European research and innovation (H2020-SC6-ENG-GLOBALLY-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 2997457.5
EU funding (EUR): 2997457.5
Participants: 12
Project status: CLOSED

This CSA intends to establish and deploy the Centre for Europe-Brazil Business Innovation Cooperation (CEBRABIC). The Centre will connect and support European Research & Innovation & Business (R&I&B) organizations in the Brazilian market, while strengthening the European Union’s position as a world leader in Science, Technology and Innovation. The Centre will achieve these goals by sustainably offering a diverse set of services, including networking and partnering; business consultancy; pooling and sharing resources; investment attraction; capacity building and awareness raising. The proposed methodology for setting up CEBRABIC relies upon a pillar-based approach – each corresponding to different chapters of a Business Plan: Strategic pillar (market analysis – Work Package (WP) 1 and strategic planning (WP2)); Marketing pillar (WP3); Operational pillar (WP4); and Financial pillar (WP5). The business model implementation (WP6) and the monitoring and evaluation (WP7) are also further pillars in the CEBRABIC methodological approach. The implementation of CEBRABIC will follow a three-staged strategy: the planning stage (from M1 to M12), in which the Centre’s business model (WP1-WP5) will be developed; the piloting stage (M12 to M24), focused on delivering services on an experimental basis (WP6); and the full implementation stage (M24-M48), in which CEBRABIC will be established as an independent legal entity and as a financially self-sustainable organization. As an open and dynamic Centre, CEBRABIC will build upon synergies and complementarities with relevant R&I&B organizations, particularly with European R&I&B organizations with presence in Brazil and SENAI Innovation Institutes, aiming to increase, diversify and consolidate the CEBRABIC service demand and offer. The project is implemented by a partnership of 12 organizations, led by Fraunhofer Gesellschaft, and including leading R&I&B organizations from Brazil, Portugal, Spain, Austria, Belgium, Hungary and Turkey.

Keywords: business innovation corporation,innovation and research network,european union,brazil
AirEx - Smart Ventilation Control (AirEx)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The AirEx innovation project is led by the U-Floor Technologies Ltd. (“UT”), a UK-based small start-up, focusing on the development and rapid scale-up of fabric efficiency technologies in homes, to tackle energy efficiency and fuel poverty. Problem identified: Buildings are responsible for 36% of the EU’s CO2 emissions . While new builds are constructed to a higher energy efficiency (EE) standard, 42% of the North-, and Western-European housing stock was built pre-1960 with drastically lower efficiency. Energy efficiency measures can broadly be divided into 2 categories: a) those with an attractive payback that are already widely adopted and there is little room for incremental gains (e.g. loft insulation); b) those with prohibitive capex (long payback), where take-up is dependent on government support schemes (e.g. solid wall insulation, double-glazing funded by the Energy Company Obligation), that have been progressively withdrawn. Landlords and homeowners with constrained budget to spend on energy upgrades, will be looking for the next ‘low hanging fruit’: a low-cost, high-impact intervention. We identified a huge untapped potential in the energy saving impact of controlling air-vents (air-bricks). 1) If these air-vents are left permanently open, that leads to enormous energy waste 2) In other cases, these vents are permanently blocked by occupants, causing unintended consequences, such as mould, condensation, jeopardising occupants' health. It has become clear, that a technology which solves the problem, must balance the need for thermal efficiency and sufficient air-exchange. To exploit this opportunity, we have developed a prototype design for a cloud-based, intelligent ventilation control (AirEx), to enable significant savings on heating energy bills for residents without compromising air quality. We aim to have AirEx deployed in 75,000 homes by year 5, providing additional revenue stream of £21.7m to UT with an IRR of over 50% to seed investors.

Keywords: energy efficiency,air quality,climate change,fuel poverty,smart homes
Treat severe cases of infection at COV with XAV-19 (BRIGHT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-12-31
Duration (months): 29.0
Total project cost (EUR): 3127625.0
EU funding (EUR): 2162650.0
Participants: 1
Project status: CLOSED

Since 2014 XENOTHERA has developed a platform for producing Glyco-Humanized Polyclonal Antibodies (GH-pAb) with high efficiency and optimized safety. It has been known for decades that polyclonal antibodies are very efficient weapons in infectious diseases, either bacterial or viral, and they are established as superior to monoclonal in various viral infections. Since the beginning of the pandemic XENOTHERA has initiated a project to develop a new treatment against COVID-19 based on its technology. The product is named XAV-19 and is expected to treat patients suffering from moderate to severe pneumonia. The purpose of BRIGHT is to prepare the product, run all necessary investigation so that we can safely run a clinical trial demonstrating the efficacy of the product. This will be a phase 2 double-blind clinical trial of XAV19 versus placebo. The endpoint will be the quick recovery of patients admitted at the hospital.
Photoinduced Decarboxylative Phosphorylations (PhotoPhos)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

This proposed Fellowship brings together an Experienced Researcher from India (Ph.D. in Germany and Postdoc in Japan with an excellent academic and research background), with expertise in photocatalysis, methodology, and total synthesis, with an internationally recognized Host Laboratory in the UK under the expert supervision of Prof. Varinder K. Aggarwal FRS. His research interests focus on total synthesis, asymmetric synthesis, photoredox-driven processes, and the development of new reactivity in organic chemistry, in particular, boron chemistry. The successful realization of this highly interdisciplinary project will: ➢Enhance European excellence in organic synthesis and catalysis, which are fundamentally important branches of chemistry. ➢Enable the ER to acquire new skills in the field of organophosphorus chemistry, EDA complexes, metal-free reactions, and to develop new drug candidates in collaboration with a partner pharmaceutical company, which will expand his scientific knowledge and network. This proposed phosphorylation project is based on a new synthetic method recently developed in the host laboratory for photoinduced C-B bond formation under photocatalyst- and metal-free conditions. The proposed methodology will access highly valuable α-aminophosphonic acids from feedstock α-amino carboxylic acids, through a decarboxylative phosphorylation process driven by visible light. α-Aminophosphonic acids are used as antibiotics, herbicides, antitumor agents, and enzyme inhibitors, with broad applications in many areas of agriculture and medicine. To maximize the impact and application of the proposed decarboxylative phosphorylation in organic synthesis, enantioselective variants will also be developed to provide highly valuable enantioenriched α-aminophosphonic acids. Initially, an auxiliary approach with a chiral phosphorylating reagent will be used, before the extension to an enantioselective catalytic process using a chiral Brønsted acid catalyst.

Keywords: phosphorylation,decarboxylation,electron donor acceptor eda complexes,visible light photocatalysis
Emergence of Surface Roughness in Shaping, Finishing and Wear Processes (ShapingRoughness)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1499101.0
EU funding (EUR): 1499101.0
Participants: 1
Project status: CLOSED

Roughness on most natural and man-made surfaces shares a common fractal character from the atomic to the kilometer scale, but there is no agreed-upon understanding of its physical origin. Yet, roughness controls many aspects of engineered devices, such as friction, adhesion, wear and fatigue. Engineering roughness in surface finishing processes is costly and resource intensive. Eliminating finishing steps by controlling roughness in primary shaping or in subsequent wear processes could therefore revolutionize the way we manufacture, but this requires a deep understanding of the relevant processes that is presently lacking. Roughness emerges during mechanical deformation in processes such as folding, scratching or chipping that shape surfaces. Deformation occurs in the form of avalanches, individual bursts of irreversible motion of atoms. The central hypothesis of this project is that roughness is intrinsically linked to these deformation avalanches, which themselves are well-documented to be fractal objects. This hypothesis will be tested in large-scale atomic- and mesoscale simulations of plastic forming and fracture on state of the art high performance computing platforms. Results of these calculations will be used to develop process models for evolving the topography of large surface areas under the action of an external mechanical force, such as experienced in shaping, finishing or wear. In addition to these simulations, a public repository for sharing topography data will be build. This repository is the connection to experiments: It is a database of experimental topographies whose contents will be mined for features identified in simulations. Beyond the present project, this web-repository will advance sharing, visualization and analysis of topography data, and aid researchers to correlate surface topography with surface functionality and processing. Simulations and database lay the foundation for a rational design of surface functionality in manufacturing.

Keywords: surface topography,self affine roughness,deformation,avalanches
An alternative development of analytic number theory and applications (1stProposal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 2011742.0
EU funding (EUR): 2011742.0
Participants: 1
Project status: CLOSED

The traditional (Riemann) approach to analytic number theory uses the zeros of zeta functions. This requires the associated multiplicative function, say f(n), to have special enough properties that the associated Dirichlet series may be analytically continued. In this proposal we continue to develop an approach which requires less of the multiplicative function, linking the original question with the mean value of f. Such techniques have been around for a long time but have generally been regarded as “ad hoc”. In this project we aim to show that one can develop a coherent approach to the whole subject, not only reproving all of the old results, but also many new ones that appear inaccessible to traditional methods. Our first goal is to complete a monograph yielding a reworking of all the classical theory using these new methods and then to push forward in new directions. The most important is to extend these techniques to GL(n) L-functions, which we hope will now be feasible having found the correct framework in which to proceed. Since we rarely know how to analytically continue such L-functions this could be of great benefit to the subject. We are developing the large sieve so that it can be used for individual moduli, and will determine a strong form of that. Also a new method to give asymptotics for mean values, when they are not too small. We wish to incorporate techniques of analytic number theory into our theory, for example recent advances on mean values of Dirichlet polynomials. Also the recent breakthroughs on the sieve suggest strong links that need further exploration. Additive combinatorics yields important results in many areas. There are strong analogies between its results, and those for multiplicative functions, especially in large value spectrum theory, and its applications. We hope to develop these further. Much of this is joint work with K Soundararajan of Stanford University.

Keywords: multiplicative functions,l functions
Dynamics of modified chromatin domains (DYMOCHRO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-07-01
End date: 2024-12-31
Duration (months): 66.0
Total project cost (EUR): 1447860.0
EU funding (EUR): 1447860.0
Participants: 1
Project status: SIGNED

Cellular identity is defined by complex patterns of DNA and histone modifications, which partition our chromosomes and determine how cells interpret the genetic information. For cells to remember who they are, these modifications have to be tightly regulated over time and through cell division. Loss of cellular identity promotes different types of disease including neurological disorders and cancer. Histone modifications can spread along chromatin and can be transmitted through cell division, giving rise to chromatin position effects and cellular memory. However, the underlying molecular mechanisms are not understood. In particular, we do not know how the size and stability of modified domains is controlled, and we currently lack techniques to study these processes in real-time. Here, I propose to develop the single-molecule ‘chromatin curtains’ platform to directly visualize spreading and maintenance of histone methylation in a reconstituted system and to compare the resulting domains to those found on individual chromatin fibers isolated from cells. In a complementary approach, I will devise and set up a tunable synthetic circuit that installs and reinforces orthogonal epigenetic modifications in living cells to define the functional modules that are necessary and sufficient for chromatin position effects and cellular memory. My project combines molecular biophysics with synthetic biology to elucidate the fundamental principles that govern the dynamics of histone modifications to establish and preserve cellular identity. The chromatin curtains platform I will develop complements sequencing-based methods and will make it for the first time possible to directly assess the dynamics of histone modification patterns on single chromatin fibers under native conditions. I anticipate that the insights gained in my project will aid in the design of future strategies to control histone modifications in disease.

Keywords: chromatin,histone methylation,position effect,cellular memory,nucleation and spreading,microfluidics
Excellence in the research area of Combating and evaluation of mixed biofilms. (CEMBO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Slovakia,Netherlands
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 899985.0
EU funding (EUR): 899985.0
Participants: 4
Project status: SIGNED

CEMBO aims at developing Excellence in the Research Area of Combating and Evaluation of Mixed Biofilms. This will be achieved by twinning the Comenius University in Bratislava (CU), Faculty of Natural Sciences (FNS) with outstanding EU institutions with high expertise in the areas of anti-biofilm strategies and biofilm visualisation. The team from FNS CU has an established scientific reputation and has exploited its expertise in the development of novel future technologies. The goal of the CEMBO project is to provide CU the opportunity to learn from partners, strengthen the research potential on CU with emphasis on building a Centre of Excellence in the field, concerning different aspects of mixed biofilms spanning from basic research over dissemination of knowledge to possible applications in industry. CEMBO will allow the excellence development required for a consolidated strategic research approach and designing a set of guidelines including methodological route implemented through scientific events leading to exploitation and commercialization of the results that will have a strong regional, national, and European impact. The objectives are in line with the specific challenge and scope of the topic H2020-WIDESPREAD-2020 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. This challenge is addressed by twinning CU with 2 leading EU research institutions: Academic Medical Center at the University of Amsterdam, The Netherlands, a global leader in the development and invention of novel antimicrobial strategies to combat biomaterial-associated infections; Charité Universitätsmedizin Berlin (CHAR), Germany, one of the largest and most prestigious university hospitals in Europe, is home to the Biofilmcenter, a laboratory internationally-recognized for its excellence in the field of diagnostics in biofilm infections.

Keywords: excellence centre,building cu prestige,promotion human sources,talent development,strengthening international cooperation,university enterprise partnership