Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Controversies in Childbirth: from Epistemology to Practices (VOICEs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

VOICEs addresses some current debates on obstetrics from engaged philosophy and medical humanities. It applies the epistemological theory of controversies to the values embedded in decision-making in the field aiming at developing a particular section of values-based practice to be used in a variety of clinical contexts around childbirth. VOICEs is directed to individuals and organizations representing the three key stakeholder groups involved: users, professionals, and policymakers. Most current obstetric debates should be seen as ‘controversies’ in the following technical sense: they reflect deep disagreements in factual, methodological, or conceptual matters. Interpreting obstetric debates as controversies is a key element in changing medical practices. VOICEs will advance scientific knowledge in this area using the realist research frameworks of situated epistemology and values-based practice of what works, for whom, and in what circumstances. The action searches for applied and measurable consequences of critical epistemology on childbirth. Obstetric controversies are a perfect experimental space for evaluating the gender, epistemic, and evaluative biases that are present in dominant discourses on childbirth. The research will assess the emancipatory interest displayed in obstetric controversies. The kind of knowledge that serves this interest will be explored with the use of Wittgenstein’s language games, feminist standpoint theory, and epistemology of resistance. Understanding the epistemic basis of emancipatory action is the core motivation of this proposal. Women throughout Europe are demanding less medicalized care in childbirth that makes fuller use of midwifery skills. Other women request elective cesareans for non-medical reasons. The action addresses the autonomy, agency and multiplicity of women’s voices on childbirth; as shown in its acronym, ‘VOICEs’.

Keywords: controversies,chidlbirth,argumentation theory,values based medical practice,critical theory,emancipatory interest,feminist theory,gender,philosophy of medicine,medical humanities
United Europe – United Science – United Culture – United Night (UNIGHTED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-06-01
End date: 2019-12-31
Duration (months): 19.0
Total project cost (EUR): 150500.0
EU funding (EUR): 143500.0
Participants: 6
Project status: CLOSED

Researchers’ Night in Poznan is back! UNIGHTED is “United Europe – United Science – United Culture – United Night”! The project is a unique undertaking of science united, an opportunity to see in action scientists from different fields working together. Discover the interdisciplinary character of science, check out how various areas of science complement each other to make our life better. Take part in an innovative interdisciplinary event “Where sciences converge” and observe how scientists in various areas of science collaborate for the common good. Have a glance into research laboratories and see up close the nature of researchers’ work; observe how robots help in telemedicine, enter FutureSmartSpace and see how new technologies influence interpersonal relationships; carry out experiments in a biotechnology laboratory; uncover the mysteries of meteorites, join in dance and sports. Find out that people of science are ordinary people and their work is simply fascinating. In the context of “United Europe – United Science – United Culture” learn how common European heritage has been influencing a variety of sciences, and how researchers have been working for the common good of entire Europe. And all that thanks to science presented in a fun and straightforward way (edutainment). The UNIGHTED project contains a continuation of projects from previous 11 editions as well as many new ideas. Year after year more participants are attracted to Researchers’ Night as new generations grow up, interested in science and people of science. Every year new venues are opened and programmes are enlarged in order to accept all those interested. This year’s project aims to build on the previous ones and to shed light on novel aspects of science: its interdisciplinary character, common research work for Europe and Europeans. Researchers’ Night both in 2018 and 2019 shall be a great celebration of science, a family fun as well as an alternative to traditional Friday night activities.

Keywords: researchers night,unighted,united europe,united science,united culture,united night,wielkopolska region,poznan
DNA-origami frame platform for co-evolution ligand selection (APTAFRAME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Affinity reagents such as antibodies and aptamers are of paramount importance as tools in biotechnology and the treatment of a wide range of diseases. However, despite their scientific and economAffinity reagents such as antibodies and aptamers are of paramount importance as tools in biotechnology and the treatment of a wide range of diseases. However, despite their scientific and economic impact it remains challenging to systematically generate high-affinity ligands to cover all epitopes of a given target. Here I propose a strategy to provide spatial control over ligand discovery process leveraging the power of in vitro evolution in conjunction with the spatial addressability of DNA nanotechnology methods. Together they form a new discovery platform for the systematic and parallel generation of ligands, specifically aptamers and single-chain Fv antibody fragments (scFv), to provide coverage of epitopes at predefined targets. The proposed strategy exploits cooperative binding (avidity), by co-evolution of the affinity reagents, in the context of a defined molecular three-dimensional framework provided by DNA origami structures. This further expedites structure determination of ligand-target complexes by cryo-electron microscopy (cryo-EM). The combination of rational framework design, in vitro evolution and structural feedback provided by cryo-EM reconstructions will provide a toolbox for the systematic generation of ligands to all accessible epitopes. Our approach also provides a tool for electron microscopy reconstruction of smaller (< 100kDa) biomolecules and their molecular interactions by enhancing contrast and providing context. Once established, this approach will provide a transformational technology platform that enables the parallel interrogation of multidimensional, spatially resolved libraries, yielding cooperative ligands for highly specific target recognition, with direct applications in biosensor development, proteome analysis, diagnostics and therapy.

Keywords: dna origami,in vitro selection,dna nanotechnology,aptamers,antibody production,structural biology
Better and faster innovations with PhantoMinds’ instant automated recruiting tool for open innovators (PhantoMinds)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

70-90 percent innovatin flops- The avoidable bad investments of 10 billion euros a year! This is highly related by the innovation methods in use which are not able to deal with the fast-changing markets nowadays. In the innovation race between countries and companies, the biggest challenge for companies is to build and identify executable ideas and innovations, especially ideas and new products their customers want and buy. PHANTOMINDS is a start-up from Hamburg, which was founded with the goal to become the No. 1 crowdsourcing provider for collaborative innovation development in Europe. We focus on the needs of companies to respond more flexibly and quickly to changing markets and conditions. PhantoMinds offers companies an open, digital and iterative innovation process via a crowdsourcing approach to SMEs and large companies. By doing so, PhantoMinds enables SMEs to use the crowdsourcing community platform to develop ideas and innovations by using the perspectives, expertise and knowledge from the creative community and/or in combination with external experts and the company’s clients.We have already designed and implemented a new module as a "big data" solution named "open innovator/lead user internet screening for companies" on twitter, facebook and linkedin. The key market of our solution is the market for Innovation Management. This market with a volume of 379 M€ in 2017 is developing extremely rapid with a CAGR (2017-2022) of 29%. Our goal is to achieve a mar-ket share of approximately 10% in Europe within the next 5 years, which is about 8,7M€.

Keywords: agile innovation,open innovation,user recruiting,innovation management,idea management,crowdsourcing innovation
Is rodenticide use disrupting the natural autoregulation of vole populations? (VOLES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-16
End date: 2017-11-15
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Humans modify ecosystems to maximise benefits from natural resources and as a result wildlife adapts ecological relationships. For instance, voles show multiannual population cycles and predators respond numerically, possibly limiting vole populations. Voles also damage crops and reduce food available for livestock. Subsequently, farmers respond using anticoagulant rodenticides (ARs) to control voles. That means indirect control of predators by secondary exposure or by reduction of food sources. Therefore, ARs will be acting analogously as a superpredator, impeding the natural autoregulation of vole populations. Here the Experienced Researcher will become an ecologist and ecotoxicologist and learn to use cutting-edge Bayesian state space models to determine the superpredator role of ARs in both predator and prey dynamics. To do that, he will work in the Universities of Franche-Comté (UFC, France) and Aberdeen (UNIABDN, UK), the Doubs Hunting Federation (FDC25), but also work hand-in-hand with farmers, stakeholders, etc. about vole populations in western Europe. He will also collaborate with small mammal work groups involved in research about small mammal surges. By combining multidisciplinary and intersectoral knowledge, the project will address the deleterious effect of pest control by poisoning ecosystems. In addition, it will show predation as one underestimated tool for pest control. By direct contact with interested parties, the Experienced Researcher will become fully involved with groups related to the hunting industry, among others, which will enable him to develop consultancy services about small mammal pests and control methods. He will also boost his research carrier and become a senior post-doc dealing with strongly applied issues of ecology and ecotoxicology with strong links between international research institutions, maximising the chances to get a permanent position.

Keywords: arvicola terrestris,cyclic dynamics,microtus spp,mustela spp,pest control,top down and bottom up processes,secondary exposure,superpredation,vulpes vulpes,western europe
Exploit population imaging to unravel resistance to Alzheimer's disease (DIVERT-AD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2025-03-25
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: SIGNED

Preventing or delaying late life cognitive impairment and dementia through lifestyle interventions is one of the greatest global challenges of the 21st century. The long preclinical phase of dementia offers an ideal time window for prevention measures, but the best timing and target group is not known. In this regard, it will become essential to understand why some elderly at-risk individuals are resistant to developing significant brain pathology and why in those with manifested brain pathology, some individuals are resilient against cognitive decline. In DIVERT-AD, I aim to unravel how modifiable lifestyle factors contribute to resistance and resilience to dementia by exploiting longitudinal population brain imaging. The key objectives are to determine whether a favourable lifestyle profile in mid- and late-life can attenuate (1) higher early-life risk of developing neuropathology, and/or (2) the adverse effect of neuropathology on cognition and then (3) to apply this knowledge to one of the first population-based positron emission tomography investigations of amyloid pathology, the key hallmark of Alzheimer’s disease. To achieve these goals, I will combine genetics, lifestyle, neuropsychology and brain imaging data from three large population-based cohorts, the Rotterdam Study, Framingham Heart Study and UK Biobank, including a total of ~47,000 participants. Neuropathology will be first determined by magnetic resonance imaging techniques measuring neurodegenerative and vascular pathologies and will be later refined by molecular imaging of amyloid plaques (~700 participants). Advanced epidemiological methods will be used to account for time-varying effects of lifestyle measures and confounders. Results from DIVERT-AD will provide unique insights into the impact of lifestyle factors on the brain and cognition in the preclinical phase of dementia. In turn, these insights are of major importance for developing targeted prevention strategies.

Keywords: population imaging
Insights from Population Genomics to the Evolution of Host Specificity in Insect Fungi (GenoSpec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-16
End date: 2017-11-15
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

GenoSpec” aims at understanding the genomic processes underlying host adaptations of the ants-specific fungi from the species complex Ophiocordyceps unilateralis sensu lato by using a population genomics approach. This knowledge will contribute to the understanding of adaptive evolution, which is a major topic in evolutionary biology, and has potential applications in the development of fungal biological control agents against insect pests. Strains of O. unilateralis specific to three different ant species will be isolated from Thailand and their genomes will be sequenced, to identify the genomic changes involved in adaptation, e.g., the genes with signatures of positive selection or specific to particular hosts. Various sampling sites will allow inferences on the recent demographic history that could blur the footprint of positive selection. Dr. Noppol Kobmoo will bring his knowledge and skill on these particular fungi to enrich the expertise and the panel of biological models of the host institution (ESE laboratory, Université Paris-Sud, FRANCE) while gaining new expertise on population genetics at a genomic level. This project will start a fruitful collaboration between the host institution and BIOTEC (THAILAND) where the Fellow will return permanently after the project.
Realization of water permeation kinetics in two-dimensional nanocapillaries to develop desalination and energy harvesting membranes (GraFludicDevices)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Exploration of molecular transport in nanometre (nm) and sub-nm capillaries has big implications in the emergence of novel nanofluidic phenomena with interesting applications, including desalination, water purification, energy harvesting and smart membrane technologies. Recent advances in graphene and other two-dimensional (2D) materials based membranes with interlayer gallery of nanochannels have witnessed high water-ion selectivity and fast water permeation—manifesting their potential for desalination and smart membrane applications. However, a systematic and extensive experimental investigation of water permeation kinetics, including the demonstration of slip effects, in these atomically smooth 2D nanochannels is still lacking. Therefore, the main objective of the current research proposal is to gain a complete mechanistic understanding of water transport in nanochannels made of different 2D materials, which is crucial for the rational design of functional membranes for energy and environmental applications. This will be achieved by employing the state-of-the-art fabrication and experimental techniques based on van der Waals assembly, Landau-Squire flow measurement set-up and ultrasonic force microscopy. In this project, atomically smooth angstrom-scale 2D nanochannel devices will be prepared to investigate the flow dynamics of water using a custom-made ultrasensitive flow measurement technique. Throughout the project, advanced modelling techniques will be utilized to fundamentally understand transport and further optimize the system. Building on these findings, a scale-up methodology will be developed for the large-scale production of membranes for desalination and energy harvesting applications. The proposed research action will address Horizon 2020 Societal Challenges related to water security and resource efficiency while advancing the field of nanofluidics and membrane technology through the development of new fabrication and flow measurement methods.

Keywords: nanofluidics,molecular transport,two dimensional materials,graphene,graphene oxide,fluid dynamics,membrane technology,desalination,water energy nexus
Simplifying Aerial Intelligence (DroneGrid)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-01-31
Duration (months): 29.0
Total project cost (EUR): 2595063.75
EU funding (EUR): 1816544.63
Participants: 1
Project status: CLOSED

The drone industry faces several key challenges that prevent fast adoption of drone technology by mainstream enterprises. Amongst the main challenges are: complex drone regulations, high upfront cost and inadequate drone experience. In general, there is a real need for an end-to-end solution that would enable transforming data collected by drones into actionable aerial intelligence data. DroneGrid is an enterprise platform that enables 2D and 3D aerial inspections of assets using drones, including automated analysis of actionable data. Without needing their own drone fleet, our customers can easily access commercial drone technologies through DroneGrid to gather aerial intelligence and to easily integrate them into their existing processes. We take care of subcontracting the best drone operators for our clients. This enables enterprises to take better decisions, improve staff safety, increase asset efficiency and digitise their field information. DroneGrid consists of an industrial customer app/web platform, backend AI engine and an API layer that integrates with commercial drone software, various third-party services such as weather, regulatory, operational services and enterprise ERPs. On the other side, the platform can be used by certified and pre-approved drone pilots to perform missions on ordered customer operations. DroneGrid is already available in a functional commercial version in several markets: renewable energy (solar inspections), construction and mining. In order to enter additional industries, we need to improve 3D capabilities (vertical) as well as enhance its intelligence abilities. DroneGrid was established in August 2016 and is a pioneer developer of a smart cloud-based drone solution. DroneGrid has achieved significant growth and now has an international customer base and operations in 22 countries. In 2018, DroneGrid has already secured a €1 million cash investment from Chroma Impact investment fund.

Keywords: aerial inspection,aerial intelligence,drone data platform