Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AIAS-COFUND II Fellowship Programme (AIAS-COFUND II)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Denmark
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-10-01
End date: 2024-09-30
Duration (months): 84.0
Total project cost (EUR): 9912000.0
EU funding (EUR): 4956000.0
Participants: 1
Project status: SIGNED

The overall aim of the AIAS-COFUND II Fellowship Programme is to reinforce excellent research by establishing a large scale fellowship programme offering long term fellowships (lasting 6-36 months) in which researchers gain freedom and independence to develop their own ideas with access to excellent facilities. The AIAS-COFUND II Fellowship Programme will enhance fellows’ genuine understanding of the methodologies and approaches of other scientific disciplines at the highest level, and thus make cross-disciplinary inspiration and initiatives possible. The aim is also to establish a multidisciplinary training platform to strengthen researchers’ capabilities to work anywhere in Europe and attract researchers from around the globe to Europe and thereby contributing to the European goals of increasing the numbers of researchers with innovation skills in Europe by 2020. The fellowship programme invites applicants from all scientific fields. The programme is completely bottom-up and the selection of fellows is made on the basis of research proposals from applicants with excellence as the sole selection criterion. The selection process is fair and transparent. Researchers with a minimum of 2 years of postdoctoral research experience can apply for fellowships lasting for up to 3 years. The programme offers full academic freedom to the fellows to pursue their ideas and independently develop ground-breaking ideas in a stimulating scientific environment. The AIAS-COFUND II Programme has a distinct focus on career development for especially young researchers offering both academic mentorship, career development in transferable skills, organised networking with industry and opportunities to plan and carry through large-scale multidisciplinary and international conferences. All fellows have wide opportunities to travel, to do field work, to connect with international networks and to carry out short-term secondment in industry or the non-academic sector locally or abroad.

Keywords: excellent research,multidisciplinary research environment,career development,academic mentorship,bottom up,inter sectoral outlook
Directions in Development (DIRNDL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-05-31
Duration (months): 69.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Cells in multicellular organisms organise along body and tissue axes. Cellular processes, such as division plane orientation, must be aligned with these polarity axes to generate functional 3-dimensional morphology, particularly in plants, where cell walls prevent cell migration. While some polarly localized plant proteins are known, molecular mechanisms of polarity establishment or its translation to division orientation are elusive, in part because regulators in animals and fungi appear to be missing from plant genomes. Cell polarity is first established in the embryo, but this has long been an intractable experimental model. My team has developed the genetic, cell biological and biochemical tools that now render the early Arabidopsis embryo an exquisite model for studying cell polarity and oriented division. Recent efforts already led to the unexpected identification of a novel family of deeply conserved polar plant proteins that share a structural domain with key animal polarity regulators. In the DIRNDL project, we will capitalize upon our unique position and foundational results, and use complementary approaches to discover the plant cell polarity and division orientation system. Firstly, we will address the function of the newly identified conserved polarity proteins, and determine mechanistic convergence of polarity regulators across multicellular kingdoms. Furthermore, we will use proteomic approaches to systematically identify polar proteins, and a genetic approach to identify regulators of polarity and division orientation, essential for embryogenesis. We will functionally analyse polar proteins and regulators both in Arabidopsis and the liverwort Marchantia to help prioritize conserved components, and to facilitate genetic analysis of protein function. Finally, we will use a cell-based system for engineering polarity de novo using the regulators identified in the project, and thus reveal the mechanisms that provide direction in plant development.

Keywords: cell polarity,cell division orientation,plant embryogenesis,arabidopsis thaliana,marchantia polymorpha
Trusted European SiC Value Chain for a greener Economy (TRANSFORM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Spain,Italy,Italy,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Italy,Germany,Germany,Germany,Germany,Germany,Germany,Sweden,France,France,France,France,France,France,Czechia,Czechia,United States
Call: ECSEL-IA (H2020-ECSEL-2020-1-IA-two-stage, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 89315613.51
EU funding (EUR): 20623100.94
Participants: 38
Project status: SIGNED

Silicon Carbide based power electronics use electrical energy significantly more efficient than current silicon-based semiconductors: gains from 6% to 30% are expected depending on application. TRANSFORM will provide European downstream market players with a reliable source of SiC components and systems based on an entirely European value chain - from substrates to energy converters. Its technical excellence strengthens the global competitive position of Europe. TRANSFORM improves current SiC technologies beyond state-of-the-art to serve large emerging markets for electric power conversion in renewable energies, mobility and industry. Substrate manufacturing process innovation will establish a new global standard: smart-cut technology allows high scalability, superior performance and reliability. Substrate and equipment manufacturers plus technology providers cooperate to increase maturity of the new processes from lab demonstration to pilot lines. Device manufacturers develop and tailor processes and device design based on the new substrate process, including adaptation of planarMOS and development of new TrenchMOS technology. Performance and reliability of devices is expected to increase greatly. For exploiting the potential of SiC devices, integration technologies and system design are improved concurrently, including new copper metallization processes for higher reliability and performance, module integration for high reliability and reduction of cost, and dedicated integrated driver technologies to optimize switching modes and parallel operation in high current applications. The project will demonstrate energy savings in applications (DC/AC, DC/DC, AC/DC) in the renewable energy domain, industry and automotive. TRANSFORM contributes to European societal goals and the green economy through significantly increasing energy efficiency by providing a competitive, ready-to-industrialized technology, strengthening Europes technological sovereignty in a critical field.

Keywords: sic power semiconductor value chain inverter emobility smart grid industry automation
Phase Transitions of Quantum Control (PHASEQUANTROL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Bulgaria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 121814.4
EU funding (EUR): 121814.4
Participants: 1
Project status: CLOSED

A particularly useful application of out-of-equilibrium quantum dynamics is the control of quantum matter. High-precision quantum control defines a cutting edge frontier in developing quantum technology: high-fidelity preparation of target states with prescribed properties, experimental studies of novel phases of matter, and reliable quantum computing depend upon our ability to manipulate quantum systems. Recently, it was discovered that optimal quantum control exhibits continuous and discontinuous phase transitions familiar from macroscopic systems: correlated/glassy phases and spontaneous symmetry breaking appear also in the optimization landscape. Despite this progress, much of the physics of this new phenomenon remains unknown. The objectives of this project are to: (1) develop theoretical understanding for phase transitions in the optimization landscapes of nonequilibrium quantum control problems, such as quantum state preparation and entanglement reduction; (2) create a new perspective on quantum many-body control and longstanding optimization problems in many-body physics by investigating the correlations between local minima of the control landscape; (3) reveal limitations of reinforcement learning and optimal control algorithms in correlated optimization landscapes. This unconventional approach to quantum control will allow us to quantify the complexity of nonequilibrium control tasks in terms of properties of the underlying phases of control. We will identify common traits in the space of almost-optimal solutions, and use them to investigate features of the controlled physical systems. The proposed research opens up a new frontier which can point to a mutually beneficial synergy between reinforcement learning, optimal control, condensed matter physics and statistical mechanics. It combines hitherto unrelated concepts to advance our understanding of nonequilibrium quantum many-body dynamics, with applications in ultracold atoms and trapped ions.

Keywords: nonequilibrium quantum dynamics,out of equilibrium quantum dynamics,many body quantum dynamics,phase transitions,reinforcement learning,optimal control
European Migrants in the British Imagination: Victorian and Neo-Victorian Culture (VICTEUR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Ireland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2498126.0
EU funding (EUR): 2498126.0
Participants: 1
Project status: SIGNED

What can the large scale literary datasets now available tell us about the ways in which national cultures develop and the role of migration in that development? This project seeks to push beyond the frontiers of current understanding of the role of migration and migrants in the dynamics of cultural change and continuity, examining intra-European migration in the Victorian period through the ‘macroscope' of text mining and the microscopes of literary scholarship. During the Victorian period Britain was the target destination for large numbers of migrants from across Europe fleeing war, political turmoil and/or economic deprivation. While this period and process has attracted considerable attention from historians, literary studies have primarily focussed on colonial racist and imperialist attitudes or representations of single ethnic groups. VICTEUR will focus on how the intra-European cultural exchange triggered by this movement of population is embedded in Victorian fiction. It will identify persistent and residual narratives and attitudes to a cross-section of European migrants by members of the host community and the cultural output of these migrants across a very large literary data set, the 35,918 volumes of fiction in the British Library Nineteenth Century Corpus operationalised for text mining via UCD’s Curatr data interface. VICTEUR will trace the residual impact of these cultural representations in neo-Victorian fiction, film and television, focussing on the period 2011-2016, combining methodologies from text mining, transmedia and cultural memory studies. The project will examine in detail the relationship between gender and national and ethnic identities within the texts and the impact of authorial gender on representations of migrants by British and migrant writers. It will develop a new transhistorical and intra-national model for understanding migration as a key driver of cultural development at the interface of gender, ethnicity and demography.

Keywords: victorian novel,natural language processing,migration and gender,neo victorianism,adaptation and transmedia,semi supervised machine learning
Commercialization of a novel tool for designing personalized nOvel MelAnoma Therapies (COMbAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Melanoma tumours develop in the pigment cells located in the skin. It is the most aggressive and treatment-resistant type of skin cancer as well as the leading cause of death among skin diseases. Moreover, melanoma’s alarming increase in incidence, especially in the young population, in combination with its propensity for lethal metastasis, illustrates an urgent need for new treatment strategies. In this PoC project, we propose developing an innovative tool, called COMbAT, for designing highly personalized therapies for melanoma patients. Each therapy will be based on existing, already designed drugs and will specifically target the driver mutations present in a patient’s melanoma genome. COMbAT involves the use of novel unique preclinical models designed to express patient-derived mutated genes in melanoma cells in a physiological manner. These models will undergo systematic combinatorial drug screens aiming to target the exact driver mutations present in patients. Such personalized targeting of the patient’s melanoma genetic landscape is key to a significantly improved mortality. Specifically, COMbAT can serve as a unique preclinical tool in the delivery of healthcare, from redefining clinical trials to targeted treatments of melanoma patients to start and a wide range of other cancer types later. Importantly, as COMbAT will allow the increased use of specific targeting of molecular drug targets, it will help to significantly lower the patient’s economic and psychological burden caused by unnecessary chemotherapy. COMbAT also holds the promise of realizing value from enormous past investments in drug candidates that were eliminated due to person-specific toxicities or lack of efficacy. We thus believe that COMbAT will enable the creation of new business models for the pharmaceutical industry which is suffering from patent expirations, threats from biotech companies, regulatory pressures, costly drug development timelines, and backlash from adverse drug reactions.

Keywords: melanoma,somatic mutation,gene knockin,gene knockout,drug screen,targeted therapy
Molecular Imprinting mediated regulation of cell behavior and related biomedical applications (MIP4CELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Tissue engineering or regenerative medicine, with its ultimate aim of developing true human replacement parts, has recently made enormous progress. The field refers to the use of human cells to replace or regenerate tissues or organs. Ideally, biomaterials for tissue engineering should efficiently mimic functionalities of the natural extracellular matrix (ECM). Hence surfaces of biomaterials should be engineered for dynamic control of cell behaviour. The objective of this proposal is to exploit molecular imprinting as a dynamic methodology for biofunctionalization and tissue engineering. Building on our previous proof of concept demonstration of systems for cell sheet harvesting, we expect to hereby obtain dynamic biofunctionalization of surfaces and overcome limitations of currently used methodologies (e.g. ligand leaching in non-covalent approach, loss of bioactivity in covalent approach, and lack of means for dynamic control of cells adhesion in both). The specific objectives of the proposal are as follows: 1) To establish bioimprinted hydrogels with thermo-responsive affinity to bioactive cell adhesive peptide as a generic platform for dynamically regulating cell adhesion and migration. 2) To develop thermo-responsive DNA aptamer imprinted hydrogels for dynamic recognition of specific cells via cell-aptamer interactions, and using as a platform for capture and release tumor cells. Therefore, this proposal will mimic the in vivo dynamic characters of the ECM and allow to obtain controllable cell behaviours in artificial biomaterials, thus having potential applications in medical diagnostic and regenerative medicine. Bringing together a highly talented and creative experienced researcher, who has already contributed decisively to the field, with a leading research group in the field of molecular imprinting and biomedicine will allow for the aforementioned objectives to be successfully accomplished.

Keywords: molecular imprinting,dynamic biofunctionalization,cell adhesion,dna aptamer,capture of circulated tumor cells
The true costs of bird flight: From the laboratory to the field (FLIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-12-31
Duration (months): 81.0
Total project cost (EUR): 1996042.5
EU funding (EUR): 1996042.5
Participants: 1
Project status: SIGNED

Flight is thought to be one of the most energetically costly of bird activities. These costs matter by virtue of their magnitude, as factors affecting flight costs can have a disproportionate impact on the overall energy balance. Flight costs are fundamentally linked to airflows, as well as behavioural responses to them, because birds react to horizontal and vertical currents by changing flight mode (i.e. flapping/ gliding), speed and route. Even minor route adjustments can radically affect the flow conditions that birds experience due to the uniquely dynamic and heterogeneous nature of the aerial environment. Yet our understanding of how airflows impact birds is in its infancy, being constrained by a lack of information on the metabolic costs of flight. Currently, the main methods for measuring flight costs in the laboratory either restrain the bird (thereby increasing energy expenditure) or suffer from low resolution, and field methods do not allow costs to be resolved in relation to fine scale movement paths. FLIGHT will use interdisciplinary approaches, integrating laboratory and field techniques, to address these grand challenges. Breakthrough methodologies will be used to (1) measure the costs of unrestrained bird flight in the laboratory and (2) derive a new proxy for power use in flight that is linked to flight performance, using accelerometry measurements from cutting-edge data loggers. Loggers will then be (3) deployed on wild birds to quantify their responses to airflows and the energetic consequences over fine scales. This will provide completely novel, mechanistic insight into the way the physical environment impacts flight costs, and (4) enable variation in flight–related energy expenditure to be modelled geographically and seasonally in model species. Overall, FLIGHT will provide new macro-ecological insight into relationships between bird distributions and flow conditions and inform assessments of how birds may be affected by changing wind regimes.

Keywords: movement ecology,accelerometry,flight,energy expenditure,wind,seabird,biotelemetry,foraging,birds,metabolic rate,migration,aerodynamics