Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
International Human Microbiome Coordination and Support Action (IHMCSA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Italy,Germany,Spain,Italy,Belgium,France,France,France,Netherlands,Denmark,Denmark,Luxembourg
Call: Coordinating and supporting research on the human microbiome in Europe and beyond (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 1999370.0
EU funding (EUR): 1999370.0
Participants: 17
Project status: SIGNED

Humans are microbial, living in close functional interaction with their skin and mucosal microbiomes. Human-microbes interplay has proven essential for the maintenance of health and well-being and profiling of microbiomes will become an essential feature of the personalized preventive nutrition and medicine of tomorrow. Europe has gained a leading position in microbiome science and yet to fulfill societal expectations, an international consensus will be essential on key aspects. These include i) clinical trial design as well as analytical standards, ii) definitions of healthy microbiomes as a function of numerous factors, accounting for confounders, iii) means of demonstrating causality of altered host-microbes interactions in diseases and iv) processes for the development of clinically relevant, validated biomarkers. The International Human Microbiome Concertation and Support Action (IHMCSA) will tackle all necessary steps to open the perspective of managing nutrition and health of the microbial human. Involving key stakeholders representing the multiplicity of actors concerned, including citizens, IHMCSA will map existing material, delineate necessary steps and pathways for innovation and build consensus on priorities and means for the future of microbiome science and its translation. This will lead to recommendations, validated by an international Strategic Steering Committee as well as academies of medicine of the world, directed to the European Commission, international research programmes, funding and regulatory agencies and decision makers of health systems. To ensure sustainability of the proposed measures, IHMCSA will promote unified repositories for sharing standards, SOPs and data, and contribute to the structuration of the European Microbiome Centers Consortium with a role in gathering world microbiome networks of excellence. With IHMCSA, human-associated microbiomes will be recognized for their true value in contributing to secure the future of mankind.

Keywords: microbiome,human health,standards,international cooperation,health data science,clinical trials,consensus building,personalized medicine
Principles of Graph Data Integration (GraphInt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-08-01
End date: 2021-07-31
Duration (months): 60.0
Total project cost (EUR): 1998339.0
EU funding (EUR): 1998339.0
Participants: 1
Project status: CLOSED

The present proposal tackles fundamental problems in data management, leveraging expressive, large-scale and heterogeneous graph structures in order to integrate both unstructured (e.g., text) and structured (e.g., relational) content. Integrating heterogeneous content has become a key hurdle in the deployment of Big Data applications, due to the meteoric rise of both machine and user-generated data storing information in a variety of formats. Traditional integration techniques cleaning up, fusing and then mapping heterogeneous data onto rigid abstractions fall short of accurately capturing the complexity and wild heterogeneity of today’s information. Having closely followed the emergence of heterogeneous information sources online, I am convinced that only an interdisciplinary approach drawing both from classical data management and from large-scale Web information processing techniques can solve the formidable data integration challenges that they pose. The following project proposes an ambitious overhaul of information integration techniques embracing the scale and heterogeneity of today’s data. I propose the use of expressive and heterogeneous graphs of entities to continuously and dynamically interrelate disparate pieces of content while capturing their idiosyncrasies. The following project focuses on three core issues related to large-scale and heterogeneous information graphs: i) the effective extraction of fined-grained information from unstructured sources and their proper integration into large-scale heterogeneous and probabilistic graphs, ii) the creation of novel physical storage structures and primitives to durably and efficiently manage the profusion of data considered by such graphs using clusters of commodity machines, and iii) the development of logical data abstraction mechanisms facilitating the effective and efficient resolution of complex analytic and data integration queries on top of the physical layer.

Keywords: graph data integration,emergent semantics
Highly Efficient and Thermotolerant Wheat (HEAT-WHEAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 2
Project status: CLOSED

Meeting the needs for a growing food security in a changing climate is currently one the key challenges for agricultural research, particularly the impact of heat waves on food production. Photosynthesis is arguably the greatest contributor to crop yield and its reduction will severely affect food production. Photosynthesis is highly susceptible to even moderately elevated temperatures and susceptibility can be in large part attributed to the enzyme Rubisco activase (RCA), one of the least thermostable photosynthesis proteins and the principal activation partner for the photosynthetic core enzyme Rubisco, that drives carbon fixation and hence growth. Considering the susceptibility of RCA to moderate and severe heat stress and its important role in photosynthesis, the need to improve its thermostability is paramount. In this project, we intend to manipulate RCA in order to enhance the photosynthetic performance, and therefore yield potential, of wheat. We intend to achieve this through sourcing and transfer of heatstable variants of RCA from relatives of wheat that have evolved in hot climates. We will identify the genetic diversity responsible for improving the thermostability of RCA through a combination of comparative bioinformatics, newly developed and refined high throughput Rubisco activation assays. State-of-the-art mutational techniques will be used to further modify wheat RCA to create RCA variants with superior thermostability and optimal activity. Improved variants of wheat RCA will be incorporated into elite wheat germplasm by means of genetic modification and breeding programs. This highly refined, technologically advanced and interdisciplinary approach has the potential to dramatically improve yield production in wheat under future climate scenarios. Furthermore, gains to the technical skill-set and the industrial setting of the research will further the fellow`s objective of having a successful scientific research career in industry.

Keywords: photosynthesis,wheat,heat stress
Dissection of Glycan Function by Engineered Tissue Models (GlycoSkin)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2023-11-30
Duration (months): 69.0
Total project cost (EUR): 1995199.0
EU funding (EUR): 1995199.0
Participants: 1
Project status: SIGNED

Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been severely hampered by the complexity and technical difficulties with analyzing glycans. While, the glycome (all glycans in a cell or organism) is a difficult entry point for discovery, the glycogenome (all genes involved in glycosylation) in contrast is a feasible entry point, because most of the genes controlling glycosylation are now known, and there are fewer technical barriers especially with the emergence of gene editing technologies. Our research group has pioneered the “glycogenome entry” to functional glycomics using gene editing to simplify glycosylation in cells. My research group has pioneered a next generation approach using organotypic tissue models in combination with sophisticated mass spectrometry to decipher glycan functions. The tissue model has provided the first evidence that aberrant glycosylation in cancer directly induce oncogenic features, and that glycosylation of Herpes virus is essential for viral propagation. In this proposal, I will use step-by-step genetic deconstruction of glycosylation capacities in organotypic tissue models for broad discovery and dissection of specific structure-function relationships driving normal epithelial formation, transformation and interaction with the microbiome. Specifically, I will address: 1. How glycosylation affect and shape epithelial homeostasis and transformation 2. How regulation of glycosylation fine-tunes protein functions 3. How glycans influence host-pathogen interactions in “real” epithelial tissue models

Keywords: tissue models,epithelia,skin,differentiation,mass spectrometry,crispr,cas9,genome,editing,cell cell interactions,cell matrix,glycoproteomics,glycobiology,pathogen host,envelope virus
RESpECT - Public Actions, Private Rules at the Margins: Ensuring Respect for Human Rights by Private Security Companies (RESpECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 328968.0
EU funding (EUR): 328968.0
Participants: 1
Project status: SIGNED

Private Security Companies (PSCs) have a bad reputation, with well-known allegations of human rights abuses in Iraq and Afghanistan and in other conflict zones. The International Code of Conduct for Private Security Providers, created to deal with these problems, merges public and private governance by using auditing to measure human rights compliance by PSCs. Nationally, States responded via public and private legislative and policy options to regulate PSCs operating in conflict zones including licensing, authorisation and contracts. However, there is a major problem with these regulatory regimes. The international market for security is expanding due to increased privatisation and outsourcing of public functions and services. PSCs are now offering international security services that are: (a) often in non-conflict zones; and (b) in areas that have been traditionally within the sole domain of the State e.g. prisons, immigration detention centres. Thus the current regulatory regime does not fit current needs. It is not known or understood how effective these private governance approaches can be in ensuring public roles, in this case, safeguarding human rights for marginalised groups, in particular women, children and migrants. The objective of RESpECT is to assess the perceptions, understanding and effectiveness of current international and national regulatory and policy frameworks that deal with PSC-related human rights violations against marginalised groups, using desk-top normative analysis and social research methods to gather empirical data to provide new insights into the area. These insights in turn will generate outputs and alternative regulatory models to help policymakers, governments, PSCs, auditors, and civil society actors to understand and improve public and private regulatory frameworks for international PSCs with the aim of securing tangible benefits for those vulnerable and marginalised groups worst affected – women, children and migrants.

Keywords: private security companies,security,international regulation,human rights,business and human rights,marginalised groups women,children,migrants,public,private regulation,new governance
REcycling of waste ACrylic Textiles (REACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Belgium,Switzerland,Switzerland,Hungary,France
Call: Methods to remove hazardous substances and contaminants from secondary raw materials (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-09-30
Duration (months): 40.0
Total project cost (EUR): 3267696.25
EU funding (EUR): 3267696.25
Participants: 8
Project status: CLOSED

Recycle is a common word used always more and more but continues to be low in the EU, while landfill and incineration rates remain high. One of the major problems is to have secondary raw material similar to virgin one. This is because of contamination, treatments, and so on, that lowen product performance. The REACT proposal will address the management of waste acrylic textiles coming from outdoor awnings and furnishing. A clue issue is the analysis and removal of finishing substances (fluorocarbons, melamine and acrylic resins, anti-mold agents) that affect the secondary raw material purity and their management. Then a mechanical recycling process will be implemented to obtain second life fiber and fabrics, which performance will be tested for best application. A full environment friendly process to remove hazardous materials on finishing of waste acrylic textile will be investigated and developed to enhance their recycling, improve sustainability and reduce environmental and health risk. The removing of finishing products via chemical reaction will involve the combination of many factors and has never been studied in this sector. Final goal is a fully compatible recycled acrylic textile for reuse and guidelines for hazardous chemicals removing from finished textile with innovative investigation techniques. The main objectives of this proposal, 36 months long, are therefore: to remove those substances up to 93%; re-use the acrylic textiles as raw material for other production cycles, also in combination with virgin fibres to reach 3,300 tons total of waste prevented from disposal; reduce the amount of landfill and incineration of acrylic textiles of at least 30% for the outdoor sector (awnings and furnishing). At the end of the project, we aim to set recommendations on the design and manufacturing of materials for recyclability and on the recycling process for standardization of the whole process, that would be applied on other sectors.

Keywords: acrylic fabric,circular economy,sustainable innovation,environment,resources and sustainability,awnings,legacy substances,investigation techniques,furnishing,finishing removal
Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections (LIGHT4LUNGS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Spain,France,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-12-01
End date: 2024-05-31
Duration (months): 54.0
Total project cost (EUR): 3493625.0
EU funding (EUR): 3493625.0
Participants: 9
Project status: SIGNED

Light4lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, which are the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The goal is to develop a novel therapeutic scheme for the treatment of the infections, whereby antibiotics will be replaced by inhalable light sources that will excite bacterial endogenous photosensitisers (e.g., iron-free porphyrins), eliminating the pathogenic bacteria by the photodynamic effect (local production of cytotoxic reactive oxygen species by the combined action of light, a photosensitiser and oxygen) irrespective of its multidrug resistance profile. The treatment will be safe for the host tissue because of its lack of self-photosensitising ability. Light4Lungs departs from current paradigms: (1) bacterial infections will be treated without antibiotics, which will be replaced by breathable light sources; (2) bacteria will be eliminated without any externally-added drug, taking advantage of endogenous photosensitisers; (3) a breathable light source will be used to elicit the therapeutic action, avoiding the use of invasive physical tethers to deliver light to the lungs. The project encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. The project combines several different scientific expertise from photonics to medicine. The results will be useful for patients with recalcitrant respiratory tract bacterial infections and will eventually be extended to other diseases in the lungs and in other internal organs. The impact reaches beyond antimicrobial resistance itself and will affect many other fields such as healthcare, nanomedicine, materials science and nanotechnology and lightning

Keywords: phototherapy,antimicrobial therapy,difficult to treat lung infections,antibiotic resistance,biofilm,aerosol,phosphorescence,nanoparticles
Self-sufficient humidity to electricity Innovative Radiant Adsorption System Toward Net Zero Energy Buildings (SSHARE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ukraine,Spain,Azerbaijan,Uzbekistan,Belarus,Russian Federation,Poland,Tajikistan,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2019-11-01
End date: 2023-10-31
Duration (months): 48.0
Total project cost (EUR): 1426000.0
EU funding (EUR): 1426000.0
Participants: 14
Project status: SIGNED

The SSHARE project will develop innovative self-sufficient envelope for buildings aimed at net zero energy, thereby contributing to the European technology and creativity through joint R&D and R&I multisectoral and international cooperation activities supported by knowledge sharing. Envelope is a combination of two breaking through technologies HUNTER-Humidity to Electricity Convertor and Advanced Radiant Panel for Buildings that will cool or heat the building depending on the time of year imitating perspiration of living beings using only atmospheric humidity as both thermal and electric energy supply. Successful realization of the project is assured by implementing a coordinated network of knowledge sharing in materials science, chemistry and mechanical engineering; by solidifying the state-of-the-art understanding in nanoelectronics and energy efficiency, and by applying bottom-up nanoengineering approaches via an international and inter-sector collaboration of highly qualified researchers from Portugal, Spain, Ukraine, Belarus, Tajikistan, Uzbekistan, Azerbaijan and intergovernmental organization Joint Institute for Nuclear Research Russian Federation. Both technological (panels fabrication) and fundamental (renewable energy) issues will be assessed by this multidisciplinary consortium. The successful realization of the project will lead to substantiated principles for the development of a new generation of building materials and hence to the creation of net zero building. Within the SSHARE project, the consortium will implement research/innovation activities by means of secondments and organizing training courses, workshops and summer schools aimed at sharing knowledge, acquiring new skills and developing the careers of the consortium members. Sharing the culture of research and innovation, the SSHARE project will allow applying recent advancements in nanotechnology science and mechanical engineering to address "Plus Energy Houses" EU 2050 concept.

Keywords: humidity to electricity,net zero energy building,radiant adsorption system,energy transfer,cool,heat