Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Overcoming the Limits of Diffraction with Superresolution Lighting on a Chip (ChipScope)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Spain,Switzerland
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 3759790.0
EU funding (EUR): 3759790.0
Participants: 8
Project status: CLOSED

The physical laws of diffraction generally limit the spatial resolution of optical systems, being about 200 nm for light in the visible range. Within ChipScope we want to overcome this limit by developing the scientific and technological basis for a completely new approach to optical superresolution, based on semiconductor nano Light Emitting Diode (nanoLED) arrays with individual pixel operation. The core idea of ChipScope is to use spatially resolved illumination instead of spatially resolved detection for achieving microscopy functionality with superresolution. This will be made possible by developing chip-based nanoLED arrays with light emitting diode (LED) dimensions and distances much smaller than the wavelength of visible light (i.e. below the Abbe's limit). Thus, ChipScope will develop the highest resolution LED arrays in the world. These new devices will enable novel science in general and superresolution in particular. Making optical superresolution ubiquitously available is expected to lead to foundational breakthroughs in virtually every field of research and technology that makes use of optical microscopes. Within the project, the first chip-sized “ChipScope microscopes” will be developed, tested, calibrated and compared with state-of-the-art microscopy systems. During the course of the project, a game changing real-time imaging device for scientific investigation of living tissue will be used to study the in-cell mechanisms in Chronic Obstructive Pulmonary Disease (COPD) syndrome as a proof-of-concept of the new science and applications that will follow.

Keywords: led technology,superresolution imaging
INnovative Life sCIence Phd Programme in South ITaly (INCIPIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,Italy,Israel,Spain,Italy,Switzerland,Poland,Belgium,Lithuania,United States,United Kingdom,Canada
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 5493600.0
EU funding (EUR): 2746800.0
Participants: 24
Project status: CLOSED

INCIPIT is a novel international PhD programme, which aims at providing innovative multidisciplinary and intersectoral training in Life and Biomaterial Sciences. Currently, there are several nodes of excellence in the South of Italy, capable of providing competitive scientific training. However, comprehensive training programmes addressing multidisciplinarity, transferable skills and internationalization are lacking. INCIPIT addresses this gap by pooling the different and complementary expertise of 8 research institutes (from biology and genetics to statistics, engineering, computer science, chemistry and medicine) of the Consiglio Nazionale delle Ricerche (CNR), as well as the competencies of 3 Doctoral Schools and several academic, non-profit and industrial Partner Organizations. INCIPIT will apply transparent and equitable selection procedures, based on merit and on equal opportunities to recruit 35 Early Stage Researchers. INCIPIT will guarantee 1) a supportive, stimulating and multidisciplinary research environment to carry out the research projects; 2) theoretical and practical courses on developmental/stem cell biology and regenerative medicine, structural biology and biocatalysis, human disease mechanisms, cancer development and treatment, metabolism and inflammation, drug design, discovery and delivery, and computational biology; 3) a comprehensive training on transferable skills on several topics, from communication, project management, clinical trials, the principle of the 3 Rs for the use of animals, to intellectual properties and entrepreneurship; and 3) exposure to the industry sector. The ultimate goal is to train the next generation of researchers to become a very attractive source of employment in both the Italian and European labour markets. INCIPIT will be a pilot project, paving the way to the consolidation in the South of Italy of an international PhD programme, with close collaboration among the CNR, the Universities and the industrial sector.

Keywords: life sciences,biomaterial science,innovative doctorate
House and home: physical and emotional comfort in the country house, England and Sweden c.1680-1820 (HAHPEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Physical comfort and emotional well-being are common expectations and aspirations across 21st-century Europe. This fellowship explores an important episode in the historical development of these cultural and social norms. The 18th century was a time when the wealthy, at least, had access to a growing range of goods, commodities and technologies, and were becoming increasingly aware of their individual identity. The research focuses on the changing relationship between physical and emotional comfort in the context of the country house, and explores a number of key questions about how the desire for comfort related to gender and life course, and to material objects and the growing specialisation of domestic spaces; how it was perceived through different senses and how it was juxtaposed with feelings of discomfort; and how it was conceived and experienced in two contrasting countries within Europe – places with very different societies, economies and climates. The research draws on a wide range of archival sources and material objects, and engages with a variety of social and cultural theories and research methodologies: textual, statistical and artefactual. It is characterised by strong engagement with the heritage sector, through the provision of new interpretive frameworks and materials for selected historic houses, and with the public, who are invited to become actively involved as project associates and contribute to the analysis of objects and archives. Successfully completing of the project will involve knowledge transfer between the researcher and host institution, and will significantly develop the researcher’s career. It will produce a range of tangible outcomes, including academic publications, open access publications on dedicated web-pages, and public workshops and exhibitions, and will build sustainable networks of academics and professionals, thus enriching and integrating the ERA.

Keywords: comfort,gender,consumption,well being,material culture,country house,elite,social relations
The Global-Local Nexus of Armed Conflicts: The interlinkages between resource-fuelled armed conflicts and the EU’s raw materials supply (GLONEXACO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2018-09-10
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

The project GLONEXACO is coordinated by the Institut Barcelona d’Estudis Internacionals (IBEI), an inter-university institute of Barcelona’s public universities (Universitat Autònoma de Barcelona, Universitat Barcelona and Universitat Pompeu Fabra), and will be conducted in collaboration with the Program on Order, Conflict and Violence (OCV) at Yale University. By merging methods of Economic Geography and Conflict Studies, it scrutinises the relationship between local armed conflicts and global market dynamics in the case of natural resource trade. The objective of this research project is to study this illicit trade and to suggest policy options that help to ensure a safe supply of raw materials for Europe’s industry. It brings together two different research fields in an innovative and multidisciplinary analytical framework, called the “Global-Local Nexus of Armed Conflicts” (GLONEXACO). On the one hand, GLONEXACO will incorporate the concept of Global Production Networks (GPN) from the field of Economic Geography to map international trade streams and the role of the involved state and non-state actors. On the other hand GLONEXACO will use elements of conflict studies and look on the microdynamics of civil wars to look on the local dynamics of this trade. In practical terms, the project will use GLONEXACO for the assessment of two case studies (DR Congo and Central African Republic) with the aim of contributing specific policy recommendations both for the EU and other actors about how to curb this trade. The framework potential is not limited to its use with conflict resources, but it will also be applicable to other cases in which global economic dynamics meet local conflicts.

Keywords: eu external policy,natural resources,armed conflicts,civil wars
Organic Knowledge Network Arable (OK-Net Arable)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Italy,Austria,Estonia,Italy,Germany,Belgium,Switzerland,Belgium,Bulgaria,Hungary,Sweden,Latvia,France,Denmark,Denmark,United Kingdom
Call: Closing the research and innovation divide: the crucial role of innovation support services and knowledge exchange (H2020-ISIB-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 2185377.5
EU funding (EUR): 1936627.5
Participants: 20
Project status: CLOSED

The overall aim of the thematic network ‘OK-Net Arable’ is to improve the exchange of innovative and traditional knowledge among farmers, farm advisers and scientists to increase productivity and quality in organic arable cropping all over Europe, in order to satisfy future market demand. To achieve this, 'OK-Net Arable' has three specific objectives: 1) to create a European network of well-functioning farmer innovation groups representing the best examples of co-innovation by farmers and researchers. The network of farmer innovation groups will serve to exchange experiences in the area of arable crop production and test the innovative end-user and education material developed in the project; 2) to digest and synthesize the considerable knowledge available from the reservoir of scientific and practical knowledge in the area of organic arable farming and to identify the best methodology in learning and knowledge exchange. Based on this easily understandable education and end-user material will be developed; 3) to create a platform for knowledge exchange across Europe unique in organic farming, offering both innovative education and end-user material as well as offering opportunities for farmer-to-farmer, advisor-to-advisor or researcher-to-advisor-to-farmer learning. The multi-actor approach is prominent in this proposal: (1) at EU level with scientific partners and farmers' associations jointly coordinating the work packages; (2) on the local level with farmers, farm advisors and scientists cooperating in farmer innovation groups. The whole consortium covers in total 13 countries from all corners of Europe giving a well-balanced representation of different climate, geographical and socio-economic conditions.

Keywords: organic farming,arable cropping,productivity and sustainability,farmer innovation groups,online knowledge platform
Vascular Optical Tomographic Imaging System” We help diabetics keep their feet (VOTIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-03-31
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Epidemiological studies confirm a link between diabetes and increased PAD (Peripheral Arterial Diseases) prevalence, and diabetes is associated with a two- to four-fold increase in PAD compared to non-diabetics. PAD impedes resolution of small surface wounds and is an important predictor of diabetic foot ulcers (DFUs). DFUs are a chronic complication of diabetes. Recent studies suggest that diabetics have a 25% risk of developing a DFU over their lifetime, and when a person with PAD develops a DFU, often the DFU will not heal. Therefore, the physician who examines a patient with diabetes and foot ulcer should always assess the vascular status of lower limbs. Nevertheless, PAD detection and the assessment of its severity is a clinical challenge in diabetic patients with foot disease, due to altered clinical presentation of PAD and limitations of the diagnostic procedures: many methods analyse only the outer surface of the sk VOTIS utilises an innovative, non-invasive and patented methodology to assess the physiological health of the lower limb even before tangible symptoms appear. “Time is tissue.”VOTIS aims to promote necessary changes in the armamentarium for treating peripheral artery disease (PAD), ischaemia and low perfusion rates in diabetics. These changes support detection and preventative healthcare and will improve control over disease progression. This, in turn, will lengthen the path to necessary amputations and reduce associated health consequences and their costs. Our business opportunity is very attractive, considering the growing number of diabetics at risk for foot amputations as well as the limited ability of currently-available solutions to detect, locate, and quantify the severity of peripheral artery disease (PAD). We plan to increase our understanding of international market conditions and related risks. The current feasibility study will help us to deepen both our roll-out plan and our plan to scaleup VOTIS

Keywords: diabetes,foot ulcer,amputation,visual imaging
Sustaining A Regional Screen Ecosystem In A Small Nation: Aarhus and the West Danish Film Fund, 2002-2019 (SARSESNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Since 2010 Danish screen production has enjoyed international attention with the popularity of high-quality films and TV series. Yet these emerge from a specific culture-political milieu that is concentrated in the capital Copenhagen. Current research on Danish production is similarly Copenhagen-centric. This imbalance means that peripheral regions of Denmark like Aarhus are neglected and underdeveloped as production hubs. This project addresses the question of how regional screen industries of small nations can be sustained and strengthened by examining the site-specific activities of the West Danish Film Fund (DVF) and its collaborations with the Aarhus 2017 EU Capital of Culture project. My main objectives are to 1) produce a 'deep map' of the regional screen ecosystem in Aarhus, 2) identify the implications of new funding and support initiatives, and 3) outline strategies on how regional screen production can productively harness geography, heritage, and tourism to strengthen domestic and international ties. I utilise a combination of qualitative and quantitative methodologies in screen studies to achieve these goals. Through a 4-week secondment at DVF and close links between Aarhus University (AU) and industry players, I will interview screen practitioners and policymakers across the region, examine policy and funding practices, analyse quantitative data relating to production and distribution, and evaluate industry innovations. This project includes both transfer of knowledge to AU and the training of the candidate in advanced techniques. This interdisciplinary research will be the first to significantly deepen knowledge on the regional screen industry of Aarhus and provide policy advice, build networks, concepts and tools on how to sustain the regional screen milieu. Results will have strong applicability to other Capitals of Culture and EU regions, enhancing understanding of how regional screen industries balance national cultural policy with local identity.

Keywords: film,television,media ecology,screens,production,funding,peripheral region,cultural policy,sustainability,cultural economy,denmark,capital of culture,creative industries,small nation
Advanced Airspace Management (PJ08 AAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Spain,Italy,Italy,Italy,Ireland,Malta,Poland,Norway,Belgium,Hungary,Lithuania,Slovakia,Sweden,Norway,Belgium,France,France,France,France,France,Czechia,Netherlands,United Kingdom,United Kingdom
Call: Advanced Airspace Management (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 15431292.0
EU funding (EUR): 2738348.92
Participants: 35
Project status: CLOSED

According to EUROCONTROL’s 2013 Challenges of Growth Report, Air traffic in the ECAC region is forecast to increase by 50% between 2012-2035 (most-likely scenario). Air traffic diversity is expected to become even more complex with the emergence of Remotely Piloted aircraft Systems (RPAS) and the multi-task nature of military aerial missions. The extension of free route operations will also imply more complex and dynamic traffic patterns. Network Operations will have to become more flexible and adaptable, allowing effective balance between capacity, mission effectiveness, flight efficiency and environmental requirements on one hand, and the diversity of user requirements on the other. PJ08 Advanced Airspace Management (AAM) brings key European aviation industry partners combining the right expertise and investment to address this challenge. Aligned with the ATM Master Plan, AAM Partners focus on Dynamic Airspace Configurations (DAC) and Dynamic Mobile Areas (DMA). Compared to today’s airspace scenarios, which by their nature are static, DAC/DMA enable flexible solutions that can be dynamically adapted to traffic demand to respond to different regional/local performance objectives, which may vary in time and place. AAM Partners will further elaborate the definition of DAC/DMA, the associated data models and operational processes, validate the operational feasibility and assess the performance impact. The readiness for integration of the DAC operational process in the DCB process will be as well addressed. Automated tools to generate optimum sector design and configurations, as well as DMA optimal location and volume to meet performance targets will be developed. AAM supports the SESAR Deployment regulation and addresses European concerns on economic (more efficient use of ATM Network resources) and environmental sustainability (reduced fuel burn and emissions) of Air Transport system giving Civil and Military Users the ability to optimise their operations.

Keywords: airspace management,airspace design,dynamic airspace configurations,dynamic mobile areas,airspace reservations,airspace sectorisation,network operations plan,network performance,network manager
Nanoscale dynamics in the extracellular space of the brain in vivo (BrainNanoFlow)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2024-11-30
Duration (months): 72.0
Total project cost (EUR): 1552948.0
EU funding (EUR): 1552948.0
Participants: 1
Project status: SIGNED

Aggregates of proteins such as amyloid-beta and alpha-synuclein circulate the extracellular space of the brain (ECS) and are thought to be key players in the development of neurodegenerative diseases. The clearance of these aggregates (among other toxic metabolites) is a fundamental physiological feature of the brain which is poorly understood due to the lack of techniques to study the nanoscale organisation of the ECS. Exciting advances in this field have recently shown that clearance is enhanced during sleep due to a major volume change in the ECS, facilitating the flow of the interstitial fluid. However, this process has only been characterised at a low spatial resolution while the physiological changes occur at the nanoscale. The recently proposed “glymphatic” pathway still remains controversial, as there are no techniques capable of distinguishing between diffusion and bulk flow in the ECS of living animals. Understanding these processes at a higher spatial resolution requires the development of single-molecule imaging techniques that can study the brain in living animals. Taking advantage of the strategies I have recently developed to target single-molecules in the brain in vivo with nanoparticles, we will do “nanoscopy” in living animals. Our proposal will test the glymphatic pathway at the spatial scale in which events happen, and explore how sleep and wake cycles alter the ECS and the diffusion of receptors in neuronal plasma membrane. Overall, BrainNanoFlow aims to understand how nanoscale changes in the ECS facilitate clearance of protein aggregates. We will also provide new insights to the pathological consequences of impaired clearance, focusing on the interactions between these aggregates and their putative receptors. Being able to perform single-molecule studies in vivo in the brain will be a major breakthrough in neurobiology, making possible the study of physiological and pathological processes that cannot be studied in simpler brain preparations.

Keywords: glymphatic pathway,protein aggregates,receptor diffusion