Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Resurgent and monogenic functions in dynamical systems and number theory (RESMON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-11-01
End date: 2011-10-31
Duration (months): 24.0
Total project cost (EUR): 226974.0
EU funding (EUR): 226974.0
Participants: 1
Project status: CLOSED

This is a mobility project for Dr David Sauzin, a most experienced French CNRS researcher in mathematics, for two years in Pisa, at the SNS (CRM research center E. de Giorgi), to collaborate with prof. Stefano Marmi. The goal of the project is to develope innovative applications of Ecalle&apos;s theory of resurgent functions and Borel&apos;s theory of monogenic functions in various problems of asymptotic analysis: especially in holomorphic dynamical systems (small divisor problems) and number theory (modular forms and elliptic functions). Few mathematicians have a command of these two powerful theories, which were up to now mostly French specialities and of which Dr. Sauzin has become a recognized expert. This project will be the occasion of a synergy between French and Italian competencies. Dr Sauzin will participate to the activities of the CRM&apos;s research group &quot;Holomorphic dynamical systems and arithmetic&quot;, developing also scientific relations with prof. Marco Abate. He will also benefit from the unique scientific environment provided by Pisa&apos;s SNS, in mathematics as well as physics, e.g. appropriating tools from variational methods and geometric measure theory and developing his interest in perturbative Quantum Field Theory. In Pisa, Dr Sauzin will himself teach a course on resurgent functions and related topics at the SNS, tutor master students and PhD students, and organize an international conference in October 2009 and another one at the end of his stay. This project will contribute to enhance European scientific excellence and enrich the scientific life of one of the best poles in Italy, with interesting prospects in terms of exchanges of students between Pisa and Paris after Dr. Sauzin&apos;s re-establishment in France, where this added value to his career will help him to reach a higher position in CNRS.

Keywords: dynamical systems,differential equations,asymptotic analysis,functions,number theory,modular forms
Rich Interfaces for Verifiable Aspect Reuse (RIVAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2010-10-31
Duration (months): 13.0
Total project cost (EUR): 172618.8
EU funding (EUR): 172618.8
Participants: 1
Project status: CLOSED

Aspect-Oriented Programming (AOP) has been recognised as an important contribution to the research on modularisation techniques for software development, especially of large and complex systems. However, to date once written aspects cannot be reused safely in new contexts and applications. The proposed project aims to study techniques for extending aspect specification so that they can be safely and verifiably reused across application borders. In particular, current aspect specifications define an aspect&apos;s interface (using so-called pointcut definitions) only based on syntactic information about the structure of a base program. To enable verifiably safe aspect reuse, these interface specifications need to be extended to provide semantically rich means of expressing aspect developers’ assumptions about the context in which an aspect is to be used and the guarantees that the aspect will make to the program into which it is woven. The proposed project first uses empirical and ethnographic techniques for building a taxonomy of assumptions and guarantees aspect developers typically make. Based on this taxonomy, extensions to common AOP languages are developed and integrated into existing aspect tooling from AOSD Europe. Where possible, also automatic or semi-automatic verification techniques for such aspect specifications will be studied.

Keywords: software technology,aspect-oriented software development,aspect reuse
Integrated protein evolution model (EVOLUTIONMODEL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-07-07
End date: 2011-04-06
Duration (months): 21.0
Total project cost (EUR): 173568.66
EU funding (EUR): 173568.66
Participants: 1
Project status: CLOSED

Proteins evolve to highly diverged sequence, function and structure. The dynamics of protein evolution is fundamental for understanding how natural protein evolve, and also for creating new proteins in the laboratory for medical and industrial use. “Epistasis”, which is the interaction between the effects of mutations, is often observed in nature and is the central to understand the dynamics of evolution, because it shapes the passages in the evolution. However, epistasis has been considered to be a quite complicated phenomenon and difficult to predict, thus it seemed that the dynamics of protein evolution was difficult to understand. In this project, I propose a new integrated protein evolution model which describes the fitness of protein from the physico-chemical properties of proteins. In this model, the structure of the fitness cause of epistasis of the fitness even though there is no interaction between the effects of mutations in physico-chemical properties; The fitness of protein (enzymatic activity in the cell: v0) is multiplication of function (enzymatic activity: kcat/KM) and fraction of functional expression level of protein (enzyme concentration: [E]). And the fraction of functional expression level is non-linearly correlated to the stability of proteins (∆∆G) due to unfolding, aggregation, degradation of proteins. This model will provide a new insight of epistasis and enable us to predict and understand the dynamics of protein evolution. I will validate and refine the model comparing the experimental evolution experiments. Furthermore, I will apply this model to analyze mono-genetic disease related proteins to establish the way to diagnose potential patients. This integrated protein evolution model will revolutionize the way how we study the dynamics of protein evolution, innovate the methodology of directed evolution, and make significant impact on the study of the network and biological evolution.

Keywords: molecular evolution,protein engineering,directed evolution,clinical genetics
Understanding Notch function in cell architecture regulation (NOTCH AND CELL ARCH.)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 170733.61
EU funding (EUR): 170733.61
Participants: 1
Project status: CLOSED

Notch signalling, a cell communication pathway conserved throughout the animal kingdom, is involved in many developmental processes and linked to many diseases including cancers. While Notch signalling is well known for its function in cell fate control, it has also been implicated in regulating cytoskeleton and cell morphology. For example, Notch is required in Drosophila for the formation of an actin-myosin fence between dorsal and ventral compartments in the wing, for the migration of border cells in the ovary and for correct axon connectivity in the nervous system. However, although the regulation of cell architecture and behaviour is a key process during morphogenesis and tissue formation, it is unclear how Notch exerts its effects on these processes. The aim of this proposal is to identify and analyse new Notch target genes involved in cell architecture regulation. Amongst direct Notch targets identified through genome-wide expression array and chromatin immunoprecipitation are a cohort of genes implicated in cytoarchitecture regulation. Using a combination of genetic approaches, I intend to investigate the function of these novel genes in wing disc formation, border cell migration and axon pathfinding to elucidate their contribution to these morphogenetic processes regulated by Notch. In addition, biochemical, molecular and cellular analyses will be used to assess their functions. Through these approaches I aim to determine which genes play a role in directly transducing the consequences of Notch activation into changes in cell behaviours. Discovering genes that mediate effects of Notch on cell architecture should provide new insights not only for the understanding of Notch function in development but also for the understanding of tissue morphogenesis in general. Besides, given the importance of both Notch signalling and cell organisation integrity in many cancers these new identified factors might be of particular importance in therapeutic research.

Keywords: developmental biology,drosophila,notch,cell architecture,cytoskeleton
The effect of physical activity on muscle biology and health in statin-treated older individuals (ACTIVEAGING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 153665.69
EU funding (EUR): 153665.69
Participants: 1
Project status: CLOSED

There is a great need in today’s Europe for well trained researchers in the field of aging exercise biology. This is greatly boosted by the large increase in life expectancy and the pandemic incidence of obesity, diabetes 2 and dyslipidemias. Statins are the most effective drugs for the treatment of high cholesterol levels. However, statins are associated with several muscle problems, including rhabdomyolysis, muscle pain, weakness and cramps. These side-effects warrant attention because they limit the use of statins, decrease functional fitness and mobility as well as increase the risk of injury. This situation is particularly exacerbated in older individuals who are the major consumers of statins and who already suffer to some degree from muscle weakness. Therefore, the aim of the present study is to determine the effect of exercise –with or without prior statin administration– on skeletal muscle mass and function, physical performance, energy metabolism, blood and muscle lipid profile and oxidative stress, gait biomechanics, proprioception and quality of life. The proposed study will be the first to try to connect statins with muscle damage from molecular to organism level in an exercise context. Given the fact that taking statins combined with exercise is a very common practice, the results of this study may reveal evidence whether treatment with statins exerts beneficial, detrimental or no effects on human biology and health, particularly for the older exercising people. The fellow researcher has performed postgraduate studies in the field of exercise biology and is already director of a university-based exercise biology lab in his home country. The host institution is one of the few research institutes in Europe specializing on human biology and exercise. The scientist in charge is research lecturer in the host institute with strong experience in the field of exercise and muscle biology.

Keywords: statins,exercise,dyslipidemias,muscle damage,aging
Supersymmetry, supergravity and geometry in particle physics and string theory (SUSY SUGRA GEOMETRY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 167270.31
EU funding (EUR): 167270.31
Participants: 1
Project status: CLOSED

The Standard Model of particle physics, which has so far provided a successful description of elementary particles, is believed to be an incomplete theory. New experiments are starting to probe physics beyond the Standard Model. Supersymmetry, supergravity, and string theory are the theoretical tools that are expected to describe the new physics proposing solutions to fundamental problems such as the nature of dark matter, the unification of forces and the formulation of quantum gravity. Moreover, a symbiotic relation between string theory and mathematics has proven to be central for both fields. The present project aims at a deeper understanding of challenging features of supersymmetry, supergravity and string theories in the intersection of physics and mathematics. The applicant has recently developed a projective superspace approach to off-shell matter-coupled supergravity with eight supercharges in four- and five-dimensions. The main line of research we are proposing will focus on the application and extension of this approach. As a major application we will construct new quaternionic-Kahler geometries. The new techniques will be used to achieve a better understanding of 4D effective-actions in compactified string theory. Superspace approaches to supergravity theories are also relevant in studying extra-dimensional phenomenological scenarios in dimensions less than six. A second goal of the project concerns the study of 2D supersymmetric sigma-models having generalized complex manifolds as target spaces. Generalized complex geometry naturally arises in string theory and a better knowledge of the underlying mathematics will lead to powerful tools for the physicists. Using superspace techniques we will study the topological sectors of these theories that could give new insights on mirror symmetry, T-duality and related topics in the case of generalized-Kahler manifolds. Most importantly, applications to string compactifications with fluxes will be analyzed.

Keywords: quantum field theory,mathematical physics,relativity,geometry,supersymmetry,supergravity,string theory,superspace
Protoplanetary disks in regions of massive star formation: coupling advanced observations to models (3DPROPLYDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-06-01
End date: 2012-07-31
Duration (months): 26.0
Total project cost (EUR): 152831.96
EU funding (EUR): 152831.96
Participants: 1
Project status: CLOSED

For the last 30 years astronomers have been grappling with issues pertaining to the elemental abundance measurements of star-forming regions, since these nebulae are key to probing the chemical composition of distant galaxies. Pressing problems remain, however, in our interpretation and understanding of the emission line spectra of Galactic and extragalactic regions of massive star formation. The most important of these is the so-called abundance anomaly problem which casts considerable uncertainty on our knowledge of the composition of the local, and hence most easily measurable, regions and thus has repercussions for chemical enrichment in the more distant Universe. This proposal has the ambitious, but realistic, goal to resolve this problem in the context of an innovative study of protoplanetary disks and young stellar objects in star-forming regions. Using multi-waveband observations from the latest ground- and spaced-based techniques, and advanced numerical models, the tomography of the targets will be undertaken and new diagnostics of their physical properties and chemical element composition will be developed. Such a detailed study is essential if the long-standing ambiguity surrounding established methods in deriving chemical abundances out to distant galaxies is to be removed, and it will promote a new understanding of protoplanetary disks and the small-scale structure of the interstellar medium. The proposed research will provide first-class training to an experienced researcher in advanced observational and modelling methods, and contribute to the solution of one of the most debated problems of nebular astrophysics. In the process, it will boost his career towards scientific independence, maturity, and excellence.

Keywords: astrophysics,protoplanetary disks,nebulae,abundances,orion nebula
Evolution of Form and Function on a Unique Eukaryotic Organism (Dictyostelia) (DICTYTOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-03-01
End date: 2012-08-29
Duration (months): 24.0
Total project cost (EUR): 173167.22
EU funding (EUR): 173167.22
Participants: 1
Project status: CLOSED

The dictyostelids (social amoebae) are a major group of soil microbes that hover at the borderline of true multicellularity. With the completion of the Dictyostelium discoideum genome in late 2005 and the publication of the first molecular phylogeny in late 2006, Dictyostelia is gaining increasing importance as an evolutionary model system. It is a powerful and unique system for studying the evolution of fundamental eukaryotic cell biology, from cell-cell signalling to the origin and evolution of complexity and the evolution of cooperation in social amoebae. As bacterial predators, dictyostelid amoebas also play important roles in the ecology and health of soils. The first molecular phylogeny of Dictyostelia showed that the traditional taxonomy of the group is deeply flawed, as are the evolutionary theories upon which it is based. However, this is only a first glimpse of dictyostelid evolution, and many questions about the deeper trends in dictyostelid evolution cannot yet be addressed. These include the identity of the some of the deepest branches in the tree, and the position of the root. We will develop the dictyostelid phylogeny in three important ways by (i) incorporating &gt;50 newly identified taxa, (ii) identifying additional new taxa by culture-independent sampling, and (iii) defining the root of the tree with a multigene dataset. This proposal describes a program to characterize the biodiversity, molecular and morphological evolution of the Dictyostelia, and lay the groundwork for the study of larger trends in their ecology and role in the soil. It will be the first comprehensive studies of a group of eukaryotic amoebas.

Keywords: natural sciences,social moeba,microbes,dictyostelids,soil quality markers
Documenting old Abruzzese (ANCABR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-10-31
Duration (months): 26.0
Total project cost (EUR): 221986.8
EU funding (EUR): 221986.8
Participants: 1
Project status: CLOSED

The aim of this research is to detect and study selected documents in Old Abruzzese, a southern Italian dialect spoken in a central region of Italy. Through the study of spontaneous writings in substandard and regional Italian and Abruzzese, I wish to reconstruct the linguistic profile of this highly endangered variety and to provide the linguistic community with a corpus of novel data which will enrich the European linguistic descriptive scenario. The writings that I consider risk being destroyed by the recent cataloguing procedures that are being implemented at present at several archives/libraries. It is therefore urgent to collect and document this material which can serve as the basis for both theoretical and typological linguistic analyses as well as for socio-cultural studies on this part of Europe.

Keywords: humanities,endagered languages,southern italian dialects,archivistic documenting
Climatic forcing and local controlling factors in the sedimentary evolution of high-latitude continental margins (CLIFORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-02-01
End date: 2012-01-31
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

This project focuses on the application of the “source-to-sink” approach to the study of paleo-ice streams with the main objective of analysing and comparing the climatic forcing and its interaction with local factors in high-latitude continental margins (Southern and Northern hemispheres) during the last glacial cycle, from morphological and sedimentological studies. The “source-to-sink” approach is a novel concept that considers the continental margin as an entire system and allows the interpretation of sedimentary processes and controlling factors from the morphology and sedimentary record. The application of this approach to the study of high-latitude margins, through the identification of sedimentary systems, processes and controlling factors during the last glacial cycle, will give information on how global (climate) and local factors have interacted in the sedimentary evolution of these margins during the last glacial cycle. Thus, the proposed work will enable the comparison of a variety of systems in the Northern and Southern Hemisphere, having a great potential to the interpretation of the climatic forcing in a world-scale and providing a basis for assessing the investigation on Climate Change, which is a topic of growing international importance because of its effects on the natural systems of the planet Earth. This project will be carried out employing different datasets that include swath bathymetries, seismic reflection profiles and sediment samples. New data will be obtained in a geophysical cruise off West Greenland, and a broad database available at the SPRI will be integrated in the study.

Keywords: climate variability (climate change),geomorphology,erosion,sedimentology,source-to-sink