Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Culturally Composite Elites, Regime Changes and Social Crises in Multi-Ethnic and Multi-Confessional Eastern Europe. (The Carpathian Basin and the Baltics in Comparison - cc. 1900-1950). (ELITES08)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The study of the human past
Countries involved: Hungary
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2012-03-31
Duration (months): 39.0
Total project cost (EUR): 771628.0
EU funding (EUR): 771628.0
Participants: 2
Project status: CLOSED

The project is multi-disciplinary by character. It focuses upon socio-historical processes of the transformation and 'circulation' of educated and ruling elites in several uniquely composite (both multi-ethnic and multi-confessional) East European regional or national societies, having experienced a number of radical changes of social and political regime as well as state souvereignty in the first half of the 20th century. The historical scope of the study extends from post-feudalism to communism. Societies involved comprise Hungary, Slovakia, Transylvania, Voivodina in the Carpathian Basin, Latvia and Estonia in the Baltics. The study draws upon sociological survey methods applied to historically successive elite brackets in form of exhaustive or quasi-exhaustive computerized prosopographical data banks, based on standardized individual biographies of elite members (as permitted by mostly archival sources to be exploited). The main targets would include secondary school graduates, students and graduates of higher education, the main intellectual professions (like doctors and lawyers.), the political power elites as well as 'reputational elites' - those cited in biographical dictionaries. The information fed into our data banks help to clarify thanks to various procedures of multi-variate statistical schemes the contrasting socio-cultural selection and recruitment of elite members, their educational path from primary to higher education, their professional career, intellectual creativity as well as socio-political standing and orientation. This is the first time that large region- or country-wide elite clusters are submitted to systematic socio-historical analyses, covering simultaneously all or most markets of activity and self-assertion of educated clusters in a vast international and comparative perspective related to culturally composite societal formations.

Keywords: sociology of education,social history of elites,prosopography,etchnicity,confessions,minorities,ruling class,middle class,intellectuals,professions,baltics,central europe
The Landscape and Isobars of European Values in Relation to Science and New Technology (VALUE ISOBARS)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: A more dynamic governance of the science and society relationship
Action type: Collaborative project
Countries involved: Norway,United Kingdom,Germany,Netherlands,Austria,Portugal
Call:  (FP7-SCIENCE-IN-SOCIETY-2008-1, 2008)
Start date: 2009-06-01
End date: 2011-11-30
Duration (months): 30.0
Total project cost (EUR): 1085295.4
EU funding (EUR): 819971.0
Participants: 6
Project status: CLOSED

The goal of this project is to provide the blueprints for a value-based and value-informed new and flexible governance of the science-society relation in Europe. Furthermore, the study shall identify necessary research tasks in order to move from a generic understanding of value-based and value-informed governance to more specific mechanisms of governance that improve current practice. Emerging biotechnologies with dual use problematic and security technologies (biometrics) shall serve as pilots to test the validity of the framework. The key research challenges are: understanding the very concept of social/ethical values, improving the methodology for the study of values, identifying innovative mechanisms of platforms for value-based dialogue in civil society and citizen consultation, and assessing the potential of legal and regulatory instruments, including soft-law, to provide value-oriented framework orientation for scientific and technological development. Two specific technologies will be analyzed in these respects closely: biotechnology dealing with pathogens with a pandemic potential (biosafety and biosecurity issue), and biometrics as a security technology. The project shall result in a multi-disciplinary report that summarizes existing knowledge on social values and their relevance for attitudes to science and technology, and that furthermore sketches the blueprint of a more coherent, flexible and dynamic conception of a value-based governance of science and technology. The report is aimed at policy makers and researchers concerned about ethical issues in current or upcoming scientific and technological developments and policies. An additional report shall suggest and specify more concrete research topics within “Science in Society” and FP7 generally. Specific attention shall be given to dual-use problematic and security technologies. Feedback on the draft of the report shall be sought through an interactive website and a selected group of European experts.

Keywords: ethics of science / technology,value studies,social values,governance,soft law,biosafety,biosecurity,biometrics,participative methods,privacy
Molecular Dissection of Melanoma Progression: An integrated Pan-European Approach (TARGET-MELANOMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,Netherlands,Belgium,Sweden,Spain
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-08-01
End date: 2013-07-31
Duration (months): 48.0
Total project cost (EUR): 1736483.0
EU funding (EUR): 1736483.0
Participants: 9
Project status: CLOSED

Transformed melanocytes use several strategies to enable their progression to advanced melanoma and metastasis, including genetic and epigenetic alterations, along with disruptions to gene and protein expression. This consortium aims to identify novel biomarkers for predicting the progression and prognosis of melanoma. To achieve this, a concerted collaborative effort is proposed here between key academic and industrial partners, centred on intersectorial training of experienced researchers. Our first goal is to identify novel methylated genes via several complementary screening methods, followed by validation extensive melanoma cohorts available to the consortium. We will use the following strategies to identify methylated genes: (1) an array-based technique called MeDIP-ON-CHIP, (2) a high-throughput bisulphite-based technique developed by Illumina (to simultaneously analyse up to 800 genes over 96 samples) and (3) in silico analysis of DNA microarray data. To validate these methylation targets, we will use both qualitative and quantitative methylation-specific PCR (MSP) and determine if these methylation events correlate with melanoma progression, i.e. from benign and atypical nevi to primary and metastatic tumours. Our second goal is to validate genes that associate with melanoma progression and prognosis. For this aspect of the project, we will concentrate on the application of tissue microarray technology and associated image analysis approaches to validate molecular determinants of melanoma progression. Prioritised targets will then be functionally validated by a unique in vitro assay that models extravasation, or exit of cancer cells out of the blood stream, a key step in the metastatic process. Overall, these studies will give clues to melanoma progression, and may identify important targets for melanoma treatment. In addition, this industry-academic partnership will provide a valuable cross-disciplinary training ground for emerging researchers.

Keywords: melanoma,dna methylation,tissue-microarrays,image analysis,in-vitro studies,extravasation,biomarkers,clinical analysis,targeted therapy
Design of froths and foams with entailed durability. (DEFFED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Bulgaria
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

This proposal aims at creating a methodology for the design of froths and foams of pre-conditioned durability. Such a methodology is greatly needed nowadays, because of the numerous applications of the froths and foams. The life-time of single foam films and the durability of froths/foams will be investigated under matching conditions. The effects of the bubble speed and bubble sizes on the durability of froths/foams will be studied for a wide range of Gibbs elasticity values. Furthermore, the durability of foam films and froths/foams containing nano– and micro-hydrophilic and/or hydrophobic particles will be studied as well. The effect of the material of the foam column on the lifetime of froths and foams will be investigated additionally. In addition, a link will be established between the behaviour under identical conditions of the single foam films and the respective foam column. There is still a drastic lack of linkage in the literature between the results for foam films and foams, due to their isolated studying. Ultimately, the main factors affecting the durability of froths and foams will be brought together in a methodology for the design of foams of a wide scope of durability – from seconds to hours.

Keywords: surface chemistry,chemical engineering
Selected peptides as drug candidates directed to pain and neurodegeneration (PEP2BRAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal,Spain,Germany
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-03-01
End date: 2013-02-28
Duration (months): 48.0
Total project cost (EUR): 659895.0
EU funding (EUR): 659895.0
Participants: 5
Project status: CLOSED

BLV200703/4 is a small molecule discovered jointly by groups from the University of Lisbon (Portugal) and Girona (Spain) that proved its efficacy in analgesia from behavioural tests in rats. The same molecule was tested in a platform that screens potential pharmacological molecules/compounds for neurodegenerative diseases with positive results. The platform is owned by Bioalvo, SA (Portugal). The preliminary results so far obtained regarding efficacy and toxicology of the molecule are encouraging and the academic inventors and the industrial developers are committed to take it into preclinical tests. However, a previous phase of lead optimisation is needed where a well devised strategy will make use of medicinal chemistry methodologies combined with robust in vitro and in vivo assays, in order to achieve the best pharmacological and ADME/toxicity characteristics for our lead molecule. This requires technology, knowledge and innovation transfer since the inventors and Bioalvo are unable to perform this endeavour on their own. Synovo, a German company expert in ADME/tox tests and the University of Tuebingen, with a group expert in Medicinal Chemistry, joined Bioalvo and the Universities of Lisbon and Girona to transfer all knowledge, technology and innovation necessary to make possible that BLV200703 or one of its future derivatives reaches pre-clinical stage. This project fits the "Developability Assessment Logic Plan" of BLV200703 as established with a consulting company expert in drug development. Not only all the participants are committed to the success of this product development, they are also committed to two-ways exchange of information and technology that strength their activity in the future. For instance, in the end of this project Bioalvo SA will have a MedChem unit that will strength future development of new products and the Universities of Lisbon and Girona will be able to carry out basic early toxicology tests as part of their research.

Keywords: pain,neurodegenerative diseases,pre-clinical,early toxicity,lead
Foldamers against protein-protein interactions (FOLDAPPI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,Belgium,Germany,United Kingdom
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-02-01
End date: 2014-01-31
Duration (months): 60.0
Total project cost (EUR): 1089570.0
EU funding (EUR): 1089570.0
Participants: 5
Project status: CLOSED

The Foldappi proposal aims to investigate the potential of aromatic amide Foldamers to disrupt protein-protein interactions. The scientific goals of the project include: 1. development of synthetic methods to build foldamers with different R-group chemistries 2. development of strategies to target foldamers to protein surfaces 3. measuring in vitro properties of foldamer(s) to assess ADME profiles of these molecules In this proposal we propose to explore the use of quinoline-derived aromatic amide foldamers developed at the University of Bordeaux to inhibit protein-protein interactions, namely the interaction between interleukin 4 (IL-4) and its receptor. These foldamers have a very well defined structure that lends itself to the rational design of substituents and the production of focused combinatorial libraries of foldamers capable of interacting with the IL4/IL-4R binding epitope. They are also large enough to block a protein-protein interaction, a feat that is not possible with small molecules. The cytokine IL-4 is a key regulator of the immune system determining the formation of immune cells and immunoglobulin class switching. IL-4 is critically involved in misguided immune reactions during atopic diseases as allergy and asthma. In spite of its importance as a drug target, no small molecule inhibitor of the Il-4/IL-4R has been reported so far, warranting the use of foldamers to do the same. The three partners involved in this cooperation, namely UCB Pharma, Université Bordeaux I and Universität Würzburg each have unique expertises necessary to bring this project to completion. This combination will produce breakthrough knowledge and insights into developing chemistries that can impact in health and medical fields. Moreover, this project will contribute to the personal development of the scientists involved by improving their interdisciplinary knowledge, as well as their communication and experimental skills.

Keywords: foldamers,synthetic chemistry,combichem,computational chemistry,protein-protein interactions,il-4,allergy,structure-based design
CARBOSORB - Carbon (Nano) Sorbents for Environmental Remediation (CARBOSORB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Sweden,Spain,United Kingdom
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-05-01
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 1284892.0
EU funding (EUR): 1284892.0
Participants: 5
Project status: CLOSED

The aim of this project is to develop and manufacture permeable composite “filters” in which carbon-rich nanoparticles (or nanoporous materials) will be embedded (and contained in a recyclable 3D structure), and use these as the basis of recyclable, high performance water clean-up devices, for application in the environmental and industrial sectors. It brings together a multidisciplinary consortium of specialists in different areas of environmental (geo)chemistry, nanotechnology, and physical, analytical, synthetic, polymer and surface chemistry, working with a common aim of developing new and efficient methods of contaminant removal from surface and groundwaters, drinking waters, and trade and industrial effluents.

Keywords: environmental protection,environmental technology
Turning Wind Energy Meteorology into System Integration Services for Energy Market Participants (METEORES SERVICES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium,Germany
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 512318.0
EU funding (EUR): 512318.0
Participants: 2
Project status: CLOSED

The consortium performs research and development in energy meteorology targeting the short-term forecasting of wind power production and electric loads. This includes day-ahead forecasts,regular intra-day forecasts, uncertainty estimates, ensemble forecasting and load forecasting. Moreover the integration of energy services with wind farm SCADA systems and the remote controlling of loads are covered. The objective of the project is the development of integrated forecasting methods for wind power generation and electric demand reaching beyond the state of the art. The results should allow an efficient integration of wind power into the power system, in both economic and technical terms. They should enable the implementation of respective services to market participants in the EU internal electricity market.

Keywords: wind power forecasting,load forecasting,meteorology,decentralised power generation,demand side management,scada systems,energy economics,power transmission,database management,software engineering
Biocompatability of carbon nanoparticles with tissues of the neuromuscular system (NMS-CNT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Poland
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-05-01
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 633648.0
EU funding (EUR): 633648.0
Participants: 3
Project status: CLOSED

The partners wish to build a long-term European, industry-academia consortium, to work on the problem of repairing tissue damage in the neuromuscular system (NS). We initially seek to determine the biocompatibility of carbon nanoparticles with tissues of the NS as an essential prelude to our medium to long-term goal of developing marketable novel carbon nanotube-based implants for tissue repair of the NS. Presently, there is no satisfactory method for repairing extensive damage of the different tissues of the NS namely, nerves, muscles, ligaments and tendons. In the case of nerve lesions, the major problem associated with most of the recently developed implants is their limited capacity for organising regenerating axons appropriately for functional tissue re-innervation. We believe that CNTs due to their unique combination of physico-chemical properties could play a major role in overcoming these problems and therefore enhance tissue integration and nerve repair. In the case of damaged skeletal muscles and tendons, we envisage that CNTs could play a key role in strengthening and repair of these types of NS tissues.

Keywords: tissue regeneration,neuromuscular system,carbon nanoparticles,nanochemistry
Study of Innovative GNSS Multiconstellation Algorithms (SIGMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Netherlands,Belgium
Call:  (FP7-PEOPLE-IAPP-2008, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 596204.0
EU funding (EUR): 596204.0
Participants: 5
Project status: CLOSED

This project aims to develop innovative positioning and integrity algorithms for demanding applications. SIGMA will investigate and implement different positioning techniques based on satellite navigation, mainly focusing on the integration of signals from two different satellites systems: GPS and Galileo. Galileo, the most important technological project initiated by Europe, is expected to be ready by 2013. SIGMA will benefit from the opportunities that a multiconstellation environment offers for the evolution of high accuracy and high-integrity demanding applications. The different expertises of the participants will be exploited through joint research teams creating the ideal environment for innovation. Pildo Labs will provide is expertise on GNSS application for aviation and the requirements for this kind of systems in terms of navigation performance. Septentrio will provide its expertise on optimising GNSS algorithms for use in commercial products with limitation on memory and processor capabilities, and defining the requirements for high-accuracy demanding applications. TU Delft will support both companies with its expertise on precise positioning and advanced RAIM techniques, while CTAE will support the project through deep analysis on multipath and interference effects.

Keywords: technological sciences,aerospace engineering,gnss,galileo,multiconstellation,raim,ppp
Design and Synthesis of Novel Polymeric Materials by ROMP (SYNTOPTOMATER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The new technologies and applications, e.g. in optoelectronics, microelectronics, biotechnology and medicine necessitate accessibility of quite modern synthetic polymeric materials with continuously more sophisticated, well-defined properties and structures. One of the most challenging tasks in current chemical research is the creation of catalytic system which allows to obtain stereo-regular linear polymers with defined units. Functionalized norbornenes (NBEs), such as: exo-n(alkyl/arylene)-norbornene dicarboxyimides, 5-norbornene-exo,exo-2,3-dimethanol or 5-norbornene-exo,exo-2,3-dicarboxylic acid will be extensively used to construct ‘designer’ ROMP materials with controlled architectures (homopolymers, diblock and triblock copolymers) via well established living polymerisation (ring opening metathesis polymerisation - ROMP) in the presence of Grubbs ruthenium initiators. NBE-based ROMP materials including supported definite and reactive groups for organic synthesis (-hydroxy, -carboxy or -silyloxy), specific chromophores for photo- and optoelectronic devices will be synthesised. After that, the advanced study of photophysical and mechanical properties of all polymeric materials will be explored. This project may deliver a new approach for production of new functional macromolecules and the final results will permit to find practical applications in manufacturing.

Keywords: chemistry,polymer chemistry,homogeneous catalysis,macromolecular chemistry,organometallic chemistry,photochemistry,surface chemistry