Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
in-built Triggered Enzymes to Recycle Multi-layers: an INnovation for USes in plastic-packaging (TERMINUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Switzerland,Sweden,Norway,Lithuania,Belgium,Belgium,France,France,France,France,France
Call: Smart plastic materials with intrinsic recycling properties by design (RIA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-07-31
Duration (months): 55.0
Total project cost (EUR): 5737013.75
EU funding (EUR): 5737013.75
Participants: 15
Project status: SIGNED

TERMINUS addresses the challenge of unlocking recycling and reuse of flexible multi-layer and multi-compounds packaging materials used for food, beverages, cosmetics, pet food, fertilisers, any perishable goods in general. It will develop a range of smart enzyme-containing polymers with triggered intrinsic self-biodegradation properties, acting as adhesives or tie layers in the design and manufacturing of multi-layer plastics for food and non-food applications. The technology will be applied to biodegradable PUR-based adhesives for adhesive lamination and extrusion coating lamination, and polymers and tie layers (PBS, PLA, PPC or PCL) in blown extrusion. TERMINUS will base its innovative and challenging objectives on a cross-disciplinary team of renowned organizations with expertise in enzymatic biodegradation of polymers, thermal protection of enzymes using nm organosilica and layered double hydroxide, cyclodextrins, UV and water triggered enzymatic activity, formulation of advanced polymers, manufacturing of multilayer plastic packaging, plastics recycling. TERMINUS is based on TRL3 technologies and will reach TRL5. It will result in major market opportunities for European industrials in several well established markets ready for market opportunities: plastic packaging (TPPS, STTP), industrial enzyme applications (BIOPOX), PUR adhesives (COVESTRO), biodegradable plastics (IPC), biotech plants (OWS), mechanical recycling (SIGMA). At least 15% of improvement of economic efficiency vs. current solutions (landfilling, incineration) are expected. A reduction of landfilling for multi-layer plastic packaging over 80% together with a reduction of overall plastic landfilling by 55% will be achieved with a minimum decrease by 65% of the overall CO2 footprint. TERMINUS will be a breakthrough in reaching the 2030 European Commission objective to recycle 100% plastic packaging.

Keywords: enzymes,pur adhesives,multilayers,packaging,biodegradable polymers,polymer formulation,smart additives,bio based polymers,life cycle analysis,polymer compounding,plastics recycling
From Kurdistan to Europe: Kurdish Literary, Artistic and Cultural Activism by Kurdish Women Intellectuals (KurdishWomen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2021-11-12
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Kurdish women have been involved in film production, radio broadcasts and exhibitions, as well as in the production of a substantial number of books, journals and other publications in both Kurdish and national languages of the European states. However, the aesthetic and intellectual production of Kurdish women, which leads to the empowerment of women and advancement of gender equality in the Kurdish diaspora, has not been the subject of any notable research yet. By going beyond stereotypical portrayals of Kurdish women, presented as either victim of honour-based violence or someone who suffers violent conflict, this research will deal with the gendered experiences of Kurdish diaspora from the four regions of Kurdistan (Iran, Iraq, Syria and Turkey) in terms of the growth of aesthetic, literary and cultural practices by migrant Kurdish women in five nation-states (Belgium, France, Sweden, Germany, UK) along with their impacts on larger societal debates within a comparative approach. It will also investigate the varying migrant incorporation regimes of selected European countries, including the impacts of the recent influx of Syrian Kurdish refugees. It includes ethnographic fieldwork, along with multi-sited research techniques carried out in the capitals of selected European states, data collection of both primary sources (creative, literary and cultural productions) and secondary sources (EU documents, annual progress reports, press releases). This study has a potential to encourage the maximization of networks of educational and intellectual revitalization in European states. It will also encourage other Kurdish migrant women to become factors of change and reach others. This is an interdisciplinary project aiming to fill in a significant gap in the relevant socio-political, gender, migration and cultural academic studies and policy debates within the European Research Area. It is in line with the EC’s strategy for gender equality provision.

Keywords: kurdish migrant women,feminization of migration,cultural productions,kurdish transnational structures
Reference Certification and Commercialisation of “Universal” Mass Spectrometry Calibration Standards (SpheriCal)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mass spectrometry (MS) is an established benchmark analytical technique to analyse biomolecules, organic molecules and synthetic polymers. MS techniques such as MALDI, IM-MS and ESI (electrospray ionization) are widely used in a range of fields such as biochemistry, clinical microbiology, medicine and drug discovery. Its prominence in these fields is due to the ability to accurately measure the absolute mass, and therefore species present, in complex analytes such as raw biological media, in high throughput experiments. For example, MALDI is used clinically to identify the nature of bacterial infection through the unique biological fingerprint of each bacteria type. Critically, due to small and continuous changes in the various system components, data recorded exhibits a significant drift over time and between analysis runs, leading to peak miss-assignment and misleading data such as false positives. Therefore, mass spectrometers require regular calibration with a set of known standards in order to provide accurate and meaningful data. Without accurate calibration, MS instrumentation will not produce reliable data, limiting the advancement and efficiency of biomedical and clinical industries and environmental monitoring organizations. Existing calibrants have disadvantages such as time-consuming preparation, poor resolution, cover an insufficient mass range and lack Certified Reference Material (CRM) status. To overcome these shortcomings of the existing calibrants, PF aim to commercialize a set of cutting-edge synthetic calibration standards called SpheriCal®. We are now attempting to reinforce SpheriCal® as a calibration system with CRM status – allowing access to additional lucrative markets such as clinical diagnostics and other markets with strict regulatory requirements. Building upon successful development and validation through preliminary end-user trials, through this 6month Phase 1 project we aim to confirm the techno-economic feasibility of SpheriCal

Keywords: mass spectrometry,calibration standards,reference materials,maldi
Multphysics SIMulations of COrrosion-FATigue (SIMCOFAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Nearly all engineering structures are exposed to harmful environments and alternating mechanical loads during their service life. The combination of these two factors, corrosion and fatigue, accelerates damage and frequently leads to catastrophic failures much before the expected lifespan of the component. Understanding and predicting corrosion fatigue is considered the ultimate challenge in mechanics of materials, due to its complex multi-disciplinary and multi-scale nature. This proposal aims at achieving a breakthrough by developing new ultra-efficient computational tools that will enable resolving the microstructural character of the problem. Advanced multi-physics and damage (phase field) models will be combined with a new class of algorithms, so-called Fast Fourier Transforms (FFT), that can reduce the computational cost of resolving the microstructural behaviour of materials by several orders of magnitude. The predictions from this new generation of physically-based models will be compared with the outcome of a complementary experimental campaign and ultimately used to predict corrosion fatigue in an industrial context. The feasibility of this Action is strengthened by the applicant's pioneering work in fatigue FFT modelling and the complementary expertise of the host group in environmentally assisted damage, phase field modelling and experimental characterisation.

Keywords: multiphysics modelling,corrosion,fatigue
Transnational Maghreb and the International Prize for Arabic Fiction: Pluralism, inclusiveness, and peaceful coexistence in the contemporary Maghrebi novel (TRANSECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Morocco
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2024-11-30
Duration (months): 36.0
Total project cost (EUR): 223245.12
EU funding (EUR): 223245.12
Participants: 2
Project status: SIGNED

TRANSECT is a research project aiming to explore how the cultural and religious pluralism of the Maghreb is represented in the contemporary Maghrebi novel in Arabic and disseminated globally by means of the International Prize of Arabic Fiction (IPAF). The definition of Maghreb adopted by TRANSECT is a restricted one, only including Morocco, Algeria and Tunisia, the three States which were encompassed by the French colonial project. TRANSECT aims to explore the ways in which the national and regional identity of the Maghrebi countries has been re-constructed into multi-faceted paradigms, codes and modes of literary production. The scope of the research has been narrowed to a coherent and homogeneous corpus of selected novels drawn from the longlists of the IPAF from 2009 to 2020. The common thread of interest among these novels is both geographic and thematic, since they are all centred around the themes of inter- and intra-religious dialogue, peaceful coexistence and pluralism in the Maghreb. TRANSECT addresses two clusters of questions: 1) Which idea of the Maghreb is shaped by the novels longlisted at IPAF and sold by Abu Dhabi? How is this “Maghreb pluriel” appropriated and marketed by the Emirati cultural policymakers? Which purposes of cultural diplomacy does it serve? 2) To what extent and how do these novels address national issues before aspiring to become pieces of World literature? How do they contribute to reposition the image of the Maghreb within the Arab region? How does this literature dialogue with national reconciliation processes, contributing to cultural peacebuilding through the construction of a non-exclusionary national identity?

Keywords: maghreb,arabic novel,book prizes,postcolonialism,pluralism,religion,intellectual history,diversity,nationalism,gulf,united arab emirates,morocco,tunisia,algeria,pacific coexistence
Development and evaluation of miniaturized biosensors for diagnosis of pathogens in aquaculture (AQUASENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-16
End date: 2024-06-15
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

The aquaculture industry is essential to meet the dietary needs of the growing world population and an important contributor to the European economy and to the people’s health and welfare. However, its expansion has been limited by the great variety of diseases that affect farmed species and cause great economic losses. There is an urgent need to find new methodologies that allow cost-effective and early-detection that can be easily applied in decentralized settings or points-of-care. The main goal of AQUASENSE is the development of a new biosensor for early molecular diagnosis of aquaculture pathogens and to evaluate the use of third generation sequencing to monitor potential reservoirs of pathogens. To perform this, the turbot aquaculture will be used as a study case. A miniaturized device based on microscale solid phase extraction (µSPE) and microfluidics will be developed and optimized to perform universal highly efficient DNA extraction and purification from aquaculture samples. Then this system will be integrated with a novel biosensing module, based on isothermal amplification and CRISPR/Cas system, to develop a micro total analysis system (µTAS) suitable for resource-limited analysis. This device will be evaluated for the detection of two of the most problematic pathogens in turbot. In parallel, a miniaturized nanopore sequencer will be used to monitor the microbiome present in the samples and the potential reservoirs of pathogens, with the aid of the universal highly efficient DNA extraction device. This technology will allow more targeted treatments and reduce mortality and the use of antibiotics, improving the profitability of the sector. These objectives fit with important goals included in the Farm to Fork European Strategy (European Green Deal), such as reduce dependency on antimicrobials, improve the knowledge about microbiome and reach a more sustainable aquaculture production, all of them aimed at achieving a robust and resilient food system.

Keywords: biosensing,molecular diagnosis,miniaturized analytical devices,microfluidics,microbiology,fast dna analysis
Evolution of neuroanatomical diversity: A phylogenetic comparative analysis across vertebrates using MRI. (BrainTree)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The study of the evolution of the brain across species provides a unique perspective on the sources of normal and pathological variability in the human brain – a major challenge for neurosciences today. I propose a project to study the evolution of the vertebrate brain with unprecedented detail. I have a strong background in neuroimaging, computational neuroanatomy and the creation of platforms for real time collaboration in neuroimaging. During the last years I have worked on the analysis of the neuroanatomical development of the human brain and the evolution of primate brain folding, as well as in the development of Web tools to allow distributed collaboration among scientists. I propose to use this expertise to build the largest, open database of magnetic resonance imaging data of vertebrate brains. I will use state of the art computational neuroanatomy methods to build precise brain reconstructions and automatically extract a series of neuroanatomical measurements of regional brain volume, surface-based shape information and brain folding. In addition, I will develop new methods to capture the variability in shape and folding patterns using graph theory and deep learning algorithms. I will test different evolutionary scenarios using phylogenetic comparative methods, to estimate ancestral phenotypes, evolutionary changes, and the emergence of multivariate relationships across brain structures. My project will be developed in collaboration between the Group of Theoretical and Applied Neuroanatomy at Institut Pasteur, the National Natural History Museum in Paris and the Institute of Biology of the École Normal Supérieur. This collaboration will provide the ideal framework for my project, combining the availability of one of the world’s largest vertebrate brain collections, with leading expertise in computational neuroanatomy and phylogenetic comparative methods, crucial for my future career goal of becoming a leading researcher in brain evolution.

Keywords: computational neuroanatomy,brain evolution,phylogenetic comparative methods,open science,open data,citizen science
Investigating the microRNA-chromatin remodelling circuitry in cardiac development (MIR-CHROM-C)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Future treatments of cardiovascular conditions will benefit from our ability to harness progenitor cells or stem cells for therapeutic purpose. To achieve this promising goal the objective of this Marie-SkŁodowska-Curie Action is to dissect the molecular mechanisms that govern fundamental cellular differentiation processes in their normal physiological setting, the developing embryo. One such fundamental process is the control of cell lineage determination. This is important during both stem cell differentiation and embryo development, including heart development. In the heart, many of the diffusible signalling molecules, transcription factors and more recently non-coding RNAs and epigenetic factors that contribute to this process have been identified. This has facilitated rapid advances in our understanding of the molecular mechanisms underlying the control of cell fate choice, however many details remain to be elucidated. This Action will focus on enzyme complexes that remodel chromatin during the epigenetic changes that occur during heart development. These complexes, which consist of different BAF-subunits and a core enzyme called Brg1, determine whether or not chromatin is accessible to transcriptional regulators, and they form an important nexus governing lineage decisions. The Action will address an important gap in our understanding concerning the regulation of subunit composition of the complexes and how subunit composition affects their function. This project builds on recent pilot data and will use in vivo methods to investigate the regulation of chromatin remodelling factors by microRNAs during cardiac development in experimentally accessible chick embryos. Mechanistic gain- and loss-of-function experiments in embryos (WP1, WP2) will be complemented by genomic approaches (WP3) to determine the genome-wide dynamic coverage of BAF/Brg1 complexes during heart development.

Keywords: cardiogenesis,chromatin regulation,micrornas
Tree growth, forest carbon storage and climate change in a Canadian boreal region using a model-data fusion approach (MAIDEN-SPRUCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The boreal forest is one of the most important global carbon sinks but its carbon fluxes and total amount of sequestered carbon depend on the regional climate variability. Because of this sensitivity to climate, boreal trees are also important natural archives of current and past climate change. During this project, we will use a data-model approach to improve our understanding of the links between forests and climate in a Canadian boreal region over the last millennium. More specifically, we will adapt the process-based ecophysiological model MAIDENiso to investigate factors influencing the growth and underlying biogeochemical processes of black spruce (Picea mariana (Mill.) B.S.P.), the most representative species of the North American boreal biome. This will give an insight into carbon storage in the taiga and will provide the first multiproxy (ring widths and δ18O and δ13C in tree-ring cellulose) regional climate reconstruction in Eastern North America over the last millennium. MAIDENiso will be calibrated on a recently developed network of tree-ring data from the taiga of Quebec. This project will have important implications. First, we will get information on the capacity of black spruce forests to adapt to climate change and to act as carbon sink using an innovative approach that can be transferred to study European boreal ecosystems as well. Second, we will reduce the uncertainties on the estimates of the climate variability of the last millennium in a region that has historically been under-represented in the Northern Hemisphere network of climate reconstructions (see IPCC AR5). Finally, we will be able to analyze the impact of each climate forcing (volcanism, solar activity, CO2 concentration) on the regional climate and carbon sink variability. An important aspect of this project is its multidisciplinarity. Climatology, geochemistry, dendrochronology, tree physiology and numerical modelling will be used linking together European and Canadian scientists.

Keywords: black spruce,boreal zone,carbon storage,climate forcings,dendroclimatology,ecophysiology,forest climate relationship,multiproxy reconstruction,process based model,co2 concentration