Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel ALL-IN-ONE machines, robots and systems for affordable, worldwide and lifetime Distributed 3D hybrid manufacturing and repair operations (4D hybrid)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Italy,Germany,South Africa,Germany,Germany,Italy,Switzerland,Greece,Türkiye,Switzerland,Belgium,France,United States,United Kingdom,United Kingdom
Call: Novel hybrid approaches for additive and subtractive manufacturing machines (H2020-FOF-2016, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 9429875.0
EU funding (EUR): 4990000.0
Participants: 21
Project status: CLOSED

From aeronautics to oil&gas, complex metal parts embrace major challenges across their lifecycles from the green field intensive manufacturing to the numerous maintenance and repairing operations worldwide distributed. The synergic combination of additive and subtractive processes could overcome individual shortcomings, going beyond the simple succession of steps. 'Plug and produce' modular approach is a key factor to success for such hybridization. In this scenario, 4D will deliver 4 disruptive breakthroughs: • A set of four elementary modules specifically designed for AM that embed the control and monitoring systems which can be integrated on new or existing concepts of machines and robots to realize different processes ranging from the DED (powder and wire) to ablation and cold spray; • A new concept of CNC, constituting a high level sw layer which can be integrated on the top of commercial CNCs, and it is conceived as open to embed portions of the 4D modules control; • A validated process model to fully exploit the synergistic interactions among elementary processes; • A dedicated 4D Engineering CAD/CAE/CAM Platform, which covers the lifecycle of the reference product family where multiple processes and hybrid resources are integrated for the (re)manufacturing stage. Innovation will be physically demonstrated at three possible levels of hybridization: • Modules - Small hybrid modules, integrated on new special machines, focusing on portable units for certified in-situ repair operations; • Hybrid Machines – Hybridization on existing robots and machines; • Production lines - Hybridization of a flexible production line focusing on new concepts for AM mass production. Potential impact: >30% lifecycle cost reduction, unprecedented possibility to customise process applications by combining several processes on several different machines, concrete business perspective supported by detailed business plan with deep market and cost analysis: payback 3y ROI>20%

Keywords: additive manufacturing,hybrid technologies,all in one machines and robots,plug and produce cnc,closed loop cax chain
Milis, a novel sweet protein for use as flavouring in the food and beverage industry (Milis)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Excess sugar consumption is a major contributor to the alarming rates of obesity, diabetes, and dental disease that exist in many developed countries. According to the Credit Suisse Research Institute, close to 400M people worldwide are affected by Type II Diabetes. 4.8M people die of chronic disease every year, a number that is quickly rising. Costs to the global healthcare system are estimated at a staggering $470B per year, representing 10% of all the healthcare costs. Artificial sweeteners offer a non-caloric alternative to sugar but have health concerns of their own, and are not always effective in maintenance of a healthy diet. However their use is not totally safe. Saccharine, for example, previously used on a large scale, was abandoned as soon as it was linked with development of bladder cancer. Artificial sweetener consumption modulates the gut microbiota and raises the risk of glucose intolerance. Sweet proteins that occur naturally in some tropical plants can have a sweetness a thousand times that of sucrose. This indicates that proteins potentially represent novel lowcalorie, nutritious sweeteners – superior to either sugar or artificial sweeteners. However, producing naturally occurring sweet proteins on a large scale is challenging and limitations of their physicochemical properties will constrain their application in the food industry. Milis Bio developed “Milis”, a novel protein which will be 200 - 500 times sweeter than sugar per gram. Milis presents low caloric content, no aftertaste, and no unhealthy chemical components. Milis allows the consumer to think only about how great their food tastes, rather than worrying about what’s in it. Using a protein as a flavouring guarantees that the ingredient will be low-calorie, easily digestible, and suitable for diabetics.

Keywords: sugar,sweetener,substitute,proteins,natural,diabetics
Towards a fully decentralized distribution for next generation of travel and tourism distribution (Biztribution)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently, air travel distribution (booking and selling of airline tickets and related products) is dominated by an oligopoly of Global Distribution System (GDS) companies. This system, unchanged for the last 30 years, poses a great pressure into airlines profitability due to elevated transactions fees imposed by the GDSs. This concentrated market has resulted in the commoditization of airline contents by third parties and additionally, this obsolete model lacks the flexibility, due to constrains imposed by GDSs, to convey in an adequate way individual offers, limiting innovation and new markets creation in an evolving industry oriented towards air retailing. biztribution reinvents the industry by creating a new revolutionary automated and simple distribution model for the air travel and tourism sector. Based on blockchain Distributed Ledger Technology, we enable airlines to recover governance over their content and customers, creating a shift of paradigm towards a fully decentralized scenario in which flexibility and de-commoditization are achieved, translating into more efficient operations and significant reduction of distribution costs by avoiding overheads and intermediaries. At biztribution we think forward about new ways to understand travel and tourism industry, leveraging technology to create a customer-centric scenario. Our aim is to enable a truly new distribution model based on a collaborative, shared and decentralized model, in which all actors can provide and access content across a distributed blockchain network, resulting in benefits that percolate to the whole industry For us, the successful implementation of biztribution will have remarkable impact in our company. We estimate, it will bring cumulative revenues of €48,25M by 2023 involving the generation of more than 100 new job positions, achieving a project ROI of 3,88 by 2023.

Keywords: blockchain as a service,new distribution models,air travel distribution,travel,tourism
Understanding the role of lysosomes in the intercellular TNT-mediated spreading of α-synuclein and the impact of lysosomal dysfunction (LySyT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Over the last few decades, neurodegenerative diseases (NDs) became one of the top 10 global causes of death. The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several NDs. Misfolded alpha-synuclein (α-syn) accumulates in Parkinson’s disease (PD), the second most common ND, and recently a “prion-like” mechanism linked to the spreading of α-syn has been suggested for the pathology progression. The Zurzolo group demonstrated that α-syn fibrils spread between neuronal cells inside lysosomes through tunneling nanotubes (TNTs), thin actin-based membrane protrusions mediating intercellular transport of various cargos. As known, lysosomes move along microtubules therefore this research aims to understand how lysosomes can move inside and through actin-based TNTs. The host lab also showed that the transferred α-syn fibrils induce the aggregation of soluble cytosolic α-syn in receiving cells and this project will unravel the mechanism by which α-syn fibrils escape from lysosomes to induce the aggregation of monomers in acceptor cells. In addition, since lysosomal dysfunction is a common feature of NDs, this research will shed light on the functionality and fate of α-syn-loaded lysosomes. Lysosomal dysfunction is also a trait of Lysosomal Storage Diseases (LSDs), a group of about 50 rare inherited metabolic disorders generally caused by the defective function of a specific lysosomal enzyme leading to the lysosomal accumulation of non-degraded materials and neurodegeneration in the forms most severe. This project will investigate the correlation between LSDs and NDs and the possible implications of TNTs in LSDs that represent a new perspective for LSDs etiopathogenesis. By combining my skills in lysosome physiopathology and the host lab expertise in TNTs and PD pathogenesis, this project will provide a deep understanding of the role of lysosomes in NDs pathogenesis and valuable insights to combat these incurable diseases.

Keywords: lysosome,tunneling nanotubes,alpha synuclein,cell cell communication,lysosomal dysfunction,lysosomal storage diseases
Climate Impacts of the Atlantic Meridional Overturning Circulation (CliMOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

CliMOC is a proposal to fund a fellowship to be carried out by the Experienced Researcher (ER) Katinka Bellomo at host institution Polytechnic University of Turin, Italy (POLITO) in the department of Environment, Land and Infrastructure Engineering under the supervision of main host professor Jost von Hardenberg. The aim of the proposed work is to investigate the role of the Atlantic Meridional Overturning Circulation (AMOC) on climate impacts over Europe. Previous studies have shown an important role for the AMOC in modulating global climate change, in particular over the Northern Hemisphere and Europe. An AMOC collapse has been identified as a possible trigger of the initiation of Ice Ages. However, the influence of AMOC in future climate change is still unclear given the large inter-model uncertainty in the decline rate of AMOC, and the concurrent climate changes due to increasing concentrations of well-mixed greenhouse gases in the atmosphere. In this proposal, we advance some hypotheses for the role of AMOC in the current climate and future climate change, and we propose a hierarchy of climate model simulations to separate the role of AMOC from other processes. More specifically, we plan to implement a slab-ocean model component in the EC-Earth global climate model. Using the ocean heat fluxes from a fully-coupled EC-Earth simulation in which the AMOC is artificially weakened, we will be able to run a slab-ocean EC-Earth simulation with a high-resolution atmospheric component, which will let us investigate the role of AMOC in future climate change impacts over Europe. This work will help reduce the uncertainties in projections of future climate change by constraining the influence of AMOC.

Keywords: atlantic ocean,climate models
Open network of hyper connected logistics clusters towards Physical Internet (CLUSTERS 2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Germany,Italy,Spain,Italy,Italy,Germany,Belgium,Belgium,Belgium,Greece,Sweden,Switzerland,Belgium,Greece,France,France,Netherlands,Netherlands,United Kingdom
Call: Networked and efficient logistics clusters (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-05-01
End date: 2020-07-31
Duration (months): 39.0
Total project cost (EUR): 6329618.75
EU funding (EUR): 5998743.75
Participants: 32
Project status: CLOSED

“If we want to reach the EU objective on modal shift for all transportation beyond 300 km and attract and strengthen competitiveness of local industries at the same time, we need to drive the development of a network of hyper connected logistics multimodal clusters and their influence areas”. Clusters 2.0 Consortium Clusters 2.0. vision is to leverage the full potential of European Logistics Clusters for an efficient and fully integrated transport system in Europe making optimal use of an Open Network of Logistics Clusters and hubs starting with. Zaragoza (PLAZA), Duisburg (Duisport), Lille (Dourges), Bologna-Trieste (Interporto/port of Trieste), Brussels (BruCargo), London (Heathrow), Pireaus (PCT), Trelleborg (Port), while keeping neutral the environmental and local impacts such as congestion, noise, land use and local pollution levels. Cluster 2.0 objectives and areas of intervention are: Increase the engagement, performance and coordination of terminals and hubs at cluster level targeting: i) increase by 50% the freight managed in the cluster whit current infrastructure, ii) Double the value added activities and iii) increase economic impact in local economies by 5% yearly while keeping neutral local environmental impacts. Build a hyper connected network of logistics hubs and clusters targeting: i) increase average door-to-door vehicle load factor up to 75%, ii) increase intermodal transport in the network by 40%. Develop low cost, low capital and investment intensive transhipment enhanced solutions to reduce operational costs of transhipment by 30 %. Develop prototypes of New Modular Load Units as enhancers of the above objectives.Develop terminal management systems to increase management capacity of the terminals by 20% and reduce associated congestion by 10%. Establish and run 5 Living Labs (LLs) to test, improve an validate proposed solutions as well as to and Develop Business Models and Robust Business Plans for Clusters 2.0 solutions.

Keywords: load units transhipment network ten t
Organic Light-Emitting Diodes for Optogenetic Control of Neurons (NeurOLED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-07-18
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Optogenetics is an emerging new method in biology for the non-invasive control of neuronal behaviour with light. NeurOLED will develop and validate a novel, biocompatible light source that provides unprecedented high-resolution, real-time optogenetic control of neurons. At the heart of the new devices are organic light-emitting diodes (OLEDs) that are brought into direct contact with neuronal cells. Using microscopic patterning, we will create dense arrays of OLEDs that can stimulate the firing of individual live neurons. Initial proof-of-principle experiments will use the new OLED light source to study neuronal networks in vitro. To fully exploit the potential of OLEDs in optogenetics, neuronal networks will ultimately be investigated in vivo. We will examine the neuronal network that is responsible for locomotion in the model organism Drosophila melanogaster. To maximize spatial resolution in vivo, the light penetration depth in tissue will be optimized by systematic optical design of the spectral and angular emission characteristics of the OLEDs. Furthermore, stacked multi-colour OLEDs will be used to achieve both activation and deactivation of single neurons at very high speed and precision. Atomic layer deposition will be used as an innovative thin-film encapsulation technology to develop OLEDs that can withstand aqueous environments and can thus be brought into direct contact with neurons and biological tissue. Compared to current state-of-the-art optogenetic light sources, OLEDs will significantly advance control of neuronal behaviour thus paving the way to a better understanding of neural networks.

Keywords: organic light emitting diodes,organic electronics,optogenetics,neurons,encapsulation,biophotonics,neuroscience,drosophila
Integration and analysis of heterogeneous big data for precision medicine and suggested treatments for different types of patients (IASIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Greece,United States,United Kingdom,United Kingdom
Call: Big Data supporting Public Health policies (H2020-SC1-2016-CNECT, 2016)
Start date: 2017-04-01
End date: 2020-06-30
Duration (months): 39.0
Total project cost (EUR): 4337475.0
EU funding (EUR): 4337475.0
Participants: 12
Project status: CLOSED

The vision of IASIS is to turn the wave of data heading our way into actionable knowledge for decision makers. This will be achieved by integrating data from disparate sources, including genomics, electronic health records and bibliography, and applying advanced analytics methods to discover useful patterns. Big Data in healthcare is in its early days, and most of the potential for value creation is being unclaimed. One of the main challenges is the analysis of acquired data. While information is becoming ever easier to obtain, the infrastructure to collect, integrate, share, and mine the data remains lacking. These data are an invaluable resource for deriving insights to improve decision and policy making. The goal is to turn these large amounts of data into actionable information to authorities for planning public health activities and policies. The integration and analysis of these heterogeneous sources of information will enable the best decisions to be made, allowing for diagnosis and treatment to be personalised to each individual. IASIS aims to pave the way towards comprehensive access to data from disparate sources and the results of analysis, in the form of actionable knowledge for policy-making. The project will offer a common representation schema for the heterogeneous data sources. The infrastructure will be able to convert clinical notes into usable data, combine them with genomic data, related bibliography, image data and more, and create a global knowledge base. This will facilitate the use of intelligent methods in order to discover useful patterns across different resources. Using semantic integration of data will give the opportunity to generate information that is rich, auditable and reliable. This information can be used to provide better care, reduce errors and create more confidence in sharing data, thus providing more insights and opportunities. Data resources for two different disease categories will be explored, dementia and lung cancer.
TEchnological Consortium TO develop sustaiNabIlity of underwater Cultural heritage (TECTONIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy,Argentina,Italy,Greece,Greece,Greece,Croatia,France,Czechia
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-02-01
End date: 2025-11-30
Duration (months): 70.0
Total project cost (EUR): 1062600.0
EU funding (EUR): 1062600.0
Participants: 14
Project status: SIGNED

Documentation and conservation of Underwater Cultural Heritage (UCH) is crucial to preserve humankind’s history and traditions, safeguarding tangible testimonies of past human life while ensuring its accessibility to present and future generations. TECTONIC project will promote an intersectoral collaboration between academic and non-academic professionals (such as technical experts, archaeologists, conservator, geologists, engineers, computer scientists) working in different topics related to the UCHs to respond and find solutions to the complex issues still existing in the field of UCH. The overall aim is the exchange of skills and expertise, the training activities for the implementation, improvement and assessment of innovative materials, techniques, tools and methodologies to develop solutions and marketable products for the conservation, restoration and management of the UCH (objects, artefacts, structures, remains etc.). To achieve its overall aim, TECTONIC project will undertake innovation and development activities driven by the following objectives: Study, documentation and 3D reconstruction of the selected pilot sites; Decision support tool for UCH risk assessment in a changing environment; Conservation studies, protocols and suitable procedures for preservation/conservation activities; Development of open and low-cost robotic solutions for the inspection, documentation and monitoring of UCH; Raising the public awareness and knowledge about the importance to preserve the underwater historical and archaeological heritage. All the objectives will be devoted to stimulate new ideas that would bring to the development of new marketable products by capitalizing on the research results that will be achieved in the project, creating a link between business, research and higher education.

Keywords: cultural heritage,underwater,preservation,valorization