Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Virtual reality-Treadmill combined Intervention for enhancing Mobility and reducing falls in the Elderly (V-TIME)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Israel,Belgium,United Kingdom,Italy,Netherlands,Italy,United Kingdom,Czechia
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 7477391.2
EU funding (EUR): 5781956.8
Participants: 9
Project status: CLOSED

Falls are a major public health concern that directly affects millions of elderly Europeans, the healthcare system, and the adult children and caregivers of older people. The V-TIME approach combines cutting edge technology with emerging concepts from gerontology, neuroscience and rehabilitation to reduce fall risk in a unique way. The V-TIME multi-modal intervention consists of treadmill training (TT) that promotes walking abilities and physical fitness. A key novel addition is the simultaneous use of a virtual reality (VR) environment that challenges, implicitly teaches and enhances cognitive skills that facilitate the safe execution of many activities of daily living: visual scanning, planning, dual tasking abilities, and obstacle negotiation. Exciting pilot studies support the idea that TT augmented with VR (TT+VR) addresses the limitations of existing fall prevention interventions. Via TT+VR, V-TIME offers task-specific training in a motivating and safe environment that can readily be reproduced and standardized. The major goal of the current proposal is to establish the beneficial effects of V-TIME training in a large (n=300) and diverse group of elderly via a multi-centre, prospective randomized controlled trial. Outcomes include post-training 6 month fall incidence rates (the primary outcome), gait, physical activity (e.g., steps walked in 7 days), cognitive function, quality of life, and neuroimaging measures (fNIRS, fMRI). The effects of dosing and an extension phase will be examined (n=60). The consortium brings together world leaders in ageing, neuroscience, rehabilitation and VR technology to test a new therapy that may dramatically reduce the negative costs of falls, financial and other. The RCT is designed to show that V-TIME offers a significant and clinically relevant greater benefit compared to current clinical management; to probe brain plasticity; and to establish efficacy on fall risk, mobility, cognitive function, and functional independence.

Keywords: falls,ageing,interventions,multi-modal,brain plasticity,rehabilitation,virtual reality,executive function,parkinson's disease,mild cognitive impairment,active ageing,guidelines
Chiral Nanostructured Surfaces and Colloidal Microbots (CHIRALMICROBOTS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-02-01
End date: 2018-01-31
Duration (months): 72.0
Total project cost (EUR): 1479760.0
EU funding (EUR): 1479760.0
Participants: 1
Project status: CLOSED

From scientific publications to the popular media, there have been numerous speculations about wirelessly controlled microrobots (microbots) navigating the human body. Microbots have the potential to revolutionize analytics, targeted drug delivery, and microsurgery, but until now there has not been any untethered microscopic system that could be properly moved let alone controlled in fluidic environments. Using glancing angle (physical vapor deposition) we will grow billions of micron-sized colloidal screw-propellers on a wafer. These chiral mesoscopic screws can be magnetized and moved through solution under computer control. The screw-propellers resemble artificial flagella and are the only ‘microbots’ to date that can be fully controlled in solution at micron length scales. The proposed work will advance the fabrication so that active microbots can be applied in rheological measurements and analytics. We will use these novel probes in bio-microrheology with the potential to probe the viscoelastic properties of membranes and tissues, and to explore questions of micro-hydrodynamics. At the same time we will develop these structures as "colloidal molecules" and grow asymmetric mesoscopic particles with tailored shapes and properties. We propose experiments that allow the observation of fundamental effects, such as chiral Brownian motion, something that exist at the molecular scale, but has never been observed to date. Similarly, we will be able to demonstrate for the first time chiral separations based purely on physical fields. The proposed technical advances of the growth of nanostructured surfaces will at the same time permit wafer-scale 3-D nano-structuring for photonic and plasmonic applications, which we plan to demonstrate. We will develop a system for targeted drug delivery, study the interaction of swarms of microbots and devise techniques to control and image these swarms.

Keywords: nanostructured surfaces,physical chemistry of chirality,multifunctional particles,low reynolds numbers,micro-robotics,metamaterials,chiral colloids,magnetically actuated artificial flagella
High Efficiency Fuel Pumping (ADEPT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-01-04
End date: 2013-01-03
Duration (months): 24.0
Total project cost (EUR): 1423216.0
EU funding (EUR): 711607.0
Participants: 1
Project status: CLOSED

The concept of this project is the TRL 6 demonstration of a high speed, light weight, large capacity variable displacement piston pump for medium and large aero-engine fuel system applications, capable of high efficiency performance at fuel flows of up to 40,000 pounds per hour and pressures up to 2200 pounds per square inch. Piston pumps currently find application on the fuel systems of small and medium engines. This project aims to build on AEC’s pedigree and inherent high reliability in this market while addressing the speed limitations of the current piston pumps. By increasing the maximum speed capability the large flow output can be achieved with a smaller displacement pump, to meet the required mass target of 50 lbs. Higher speed requires a greatly increased duty, a term used to compare the relative levels of stress and velocities of the pumping elements. This higher duty performance will be achieved through application of modern materials, coatings, manufacturing technologies and advanced analysis methods. The pump shall be designed to retain the current high mean time before failure of 300,000 hours, with an overhaul life of 30,000 hours. The project is split into eight work packages, with the overall aim being to design and manufacture a variety of options for the high duty pump’s internal components to be tested within a flexible demonstrator vehicle. The optimum combination will then be identified and subjected to further testing to demonstrate TRL6, resulting in a final design proposal for a large engine application. AEC has in-house pump design, manufacture and performance and environmental test capability. However, this technology programme will require external capabilities relating to specific design and manufacturing processes and capabilities, and materials technology. Therefore, the overall strategy is for AEC to integrate the research establishments and the SMEs’ capabilities to design, make and evaluate the key component technologies.

Keywords: piston pump,aero-engine fuel system,mathematical analysis,advanced materials and coatings,test vehicle,trl6
Flight Algorithms for Disaggregated Space Architectures (FADER)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Israel
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1499999.6
EU funding (EUR): 1499999.6
Participants: 1
Project status: CLOSED

Standard spacecraft designs comprise modules assembled in a single monolithic structure. When unexpected situations occur, the spacecraft are unable to adequately respond, and significant functional and financial losses are unavoidable. For instance, if the payload of a spacecraft fails, the whole system becomes unserviceable and substitution of the entire spacecraft is required. It would be much easier to replace the payload module only than launch a completely new satellite. This idea gives rise to an emerging concept in space engineering termed disaggregated spacecraft. Disaggregated space architectures (DSA) consist of several physically-separated modules, interacting through wireless communication links to form a single virtual platform. Each module has one or more pre-determined functions: Navigation, attitude control, power generation and payload operation. The free-flying modules, capable of resource sharing, do not have to operate in a tightly-controlled formation, but are rather required to remain in bounded relative position and attitude, termed cluster flying. DSA enables novel space system architectures, which are expected to be much more efficient, adaptable, robust and responsive. The main goal of the proposed research is to develop beyond the state-of-the-art technologies in order to enable operational flight of DSA, by (i) developing algorithms for semi-autonomous long-duration maintenance of a cluster and cluster network, capable of adding and removing spacecraft modules to/from the cluster and cluster network; (ii) finding methods so as to autonomously reconfigure the cluster to retain safety- and mission-critical functionality in the face of network degradation or component failures; (iii) designing semi-autonomous cluster scatter and re-gather maneuvesr to rapidly evade a debris-like threat; and (iv) validating the said algorithms and methods in the Distributed Space Systems Laboratory in which the PI serves as a Principal Investigator.

Keywords: space systems,satellite engineering,astrodynamics
Markers for Sub-Clinical Cardiovascular Risk Assessemnt (EU-MASCARA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Austria,Belgium,Germany,Germany,Italy,Netherlands,Spain,Spain,United Kingdom,Germany,Austria,United Kingdom
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2016-05-31
Duration (months): 54.0
Total project cost (EUR): 8113788.2
EU funding (EUR): 5990880.0
Participants: 16
Project status: CLOSED

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores. The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice. EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples. The most robust biomarkers will be implemented in novel biochip based assays for clinical use.

Keywords: stratified cardiovascular medicine
Metal supported SOFC technology for stationary and mobile applications (METSAPP)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Denmark,Sweden,Austria,Sweden,Germany,United Kingdom,European organisations area,Germany,Austria
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-11-01
End date: 2015-12-31
Duration (months): 50.0
Total project cost (EUR): 8021949.67
EU funding (EUR): 3366631.24
Participants: 10
Project status: CLOSED

State of the art SOFC technology for stationary as well as for transportation application is to date being demonstrated with either planar or tubular ceramic anode-supported or electrolyte-supported SOFC cells. However, the SOFC technology faces many challenges when it comes to commercialization, since cost reduction, reliability and extended lifetime is required. In order to improve durability and cost efficiency of the cells the stacks and the system much of the development has in the past been focused on lower operation temperature, increased power density and material savings based on reduced cell and stack component thickness. Nevertheless, most of the demonstrations with ceramic cells in real system operation have until now revealed problems regarding these issues in combination with low robustness. Attention to these issues has especially been paid in connection with SOFC technology for mobile application, such as in APUs. Modelling studies as well as recent practical experience has proved how up-scaling of cells and stacks to larger more industrially relevant sizes generally leads to lower reliability in real system operation and intolerance towards system abuse and operation failures. These observations conform to the statistical distribution of mechanical properties governing the probability of failure of cells based on ceramic materials, whether it is for mobile or for stationary applications. The aim of the METSAPP project is to develop novel cells and stacks based on a robust and reliable up-scale-able metal supported technology with the following primary objectives: 1. Robust metal-supported cell design, ASRcell < 0.5 Ohmcm2, 650 C; 2. Cell optimized and fabrication upscaled for various sizes; 3. Improved durability for stationary applications, degradation < 0.25%/kh; 4. Modular, up-scaled stack design, stack ASRstack < 0.6 Ohmcm2, 650 C; 5. Robustness of 1-3 kW stack verified; 6. Cost effectiveness, industrially relevance, up-scale-ability illustrated.

Keywords: sofc,metal support,stationary applications,chp,mobile applications,apu
Biodegradable Magnetic Stent for Coronary Artery Luminal Regeneration (BIOMAGSCAR)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,Finland,United Kingdom,United States,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 6799137.64
EU funding (EUR): 5299478.0
Participants: 8
Project status: CLOSED

By 2010 1.5 million stents per year will be deployed in Europe. Although outcome for patients has improved, stents still fail because of the occurrence of restenosis and thrombosis at the site of implantation. While drug eluting stents have helped to reduce the problem of restenosis, neointimal proliferation causing restenosis can still occur. Additional concerns exist regarding drug eluting stents as there appears to be a small but real increase in late and very late stent thrombosis, particularly after discontinuation of antiplatelet therapy. The novel concept we propose is use of a biodegradable magnetised stent (BMS) to deliver a novel biological therapy offering regenerative medicine solutions to the coronary artery vessel wall. Specifically we will develop the stent technology as a platform to attract autologous progenitor cells tagged in vitro with iron nanoparticles. Once deployed, the cells will be attracted to the already implanted BMS and proliferate to form a new endothelium. We will also use over-expression of the NRP1 gene in the artery wall where it will dimerise with NRP1 receptors on the deployed cells. The NRP1 gene will be transfected by adenovirus delivered from the wall of the BMS. Over time the BMS will undergo a predictable degradation to leave a wholly biological artery through regeneration of native tissues. Currently, about 12,000 European Citizens a year suffer from late in-stent thrombosis and 120,000 from restenosis. With the knowledge and technologies developed through the BIOMAGSCAR project we aim to halve this number of patients and save 66,000 people from unnecessary suffering, saving the European healthcare system €275 million p.a. in direct costs, only 10% of the total associated costs. Our consortium includes a vascular disease therapy company, a stent research and manufacturing company, four universities and a specialist in innovative technology investment, all of whom believe our technology will dramatically change this field.

Keywords: biodegradable magnetised stent,endothelial cells,stem cell magnetic labelling,restenosis
Theory of optomechanical circuits (OPTOMECH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1499000.0
EU funding (EUR): 1499000.0
Participants: 1
Project status: CLOSED

The interaction between light and mechanical motion in nanostructures has become a research topic with significant impact and promise recently. This rapidly developing area at the intersection between nanophysics and quantum optics is also known as “cavity optomechanics”. Fundamental investigations in quantum physics and possible applications like ultrasensitive detection of small displacements, forces and masses drive this field. By now, the basic features have been demonstrated in various experiments worldwide during the past five years. These include displacement detection with precisions down to the standard quantum limit, nonlinear dynamics in optomechanical self-oscillations, and cavity-assisted optomechanical laser-cooling of vibrational modes. The concepts involved are general enough to be applicable to a large variety of different setups, extending to variants such as nanomechanical resonators in superconducting microwave circuits and clouds of cold atoms. It is now time to put these basic elements together and investigate the design of structures containing multiple interacting optical and mechanical modes. These could be used to form optomechanical “circuits” or “arrays”. Recently demonstrated nanofabricated photonic-phononic crystal structures provide one essential platform in which to realize these ideas. On the applied side, integrated optomechanical circuits might combine several functions, such as detection, amplification and general signal processing, or contribute to quantum information processing by converting information to and from the light field. On the fundamental side, arrays of optomechanical elements could be used to study the collective many-body dynamics (both classical and quantum) of these novel nonequilibrium systems. We propose to explore theoretically these possibilities, providing a guide-line for experiments and thereby unlocking the potential of such devices.

Keywords: nanomechanics,light-matter interaction,optomechanics,photonic crystals,many-body dynamics,nonlinear dynamics,quantum measurement and amplification,quantum information processing
Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Czechia,France,Austria,United Kingdom,Netherlands,Germany,Sweden,Germany,Italy,Spain,Denmark,Switzerland,Sweden,Finland,United Kingdom
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-10-01
End date: 2015-09-30
Duration (months): 48.0
Total project cost (EUR): 9958633.19
EU funding (EUR): 5999998.0
Participants: 21
Project status: CLOSED

The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen…, Enerbäck & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (“diabesity”), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.

Keywords: brown adipocyte,type 2 diabetes,brown adipose tissue,obesity,thermogenesis,beta cell