Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting 5-lipoxygenase in the context of Acute Myeloid Leukemia (Target5LO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Drug efficacy is cornerstone for successful drug discovery programs. Considering that, on average, FDA-approved drugs modulate dozens of off-targets it remains imperative to find strategies to overcome adverse drug reactions correlated with pernicious polypharmacology. In fact, several chemical entities displaying promising anticancer are discontinued from drug development pipelines due to narrow therapeutic windows in pre-clinical models. Here, we propose the development of antibody-drug conjugates exploring the unique bioactivity profile of the naphthoquinone natural product-lapachone (Lp) against acute myeloid leukemia (AML), an unmet medical need. Using a machine learning method, we disclosed Lp as an allosteric modulator of 5-lipoxygenase (5-LO), correlated its anticancer activity with 5-LO expression in blood cancers and showed its efficacy in a disseminated mouse model of AML. In this project, a comprehensive investigation of novel means for the targeted delivery of Lp to leukaemia cells is sought after, considering both the promising bioactivity profile but also the significant toxicity in untargeted dosage forms. We apply state-of-the-art synthetic medicinal chemistry to design and access cleavable linkers, and site-specifically conjugate Lp to an anti-IL7R antibody, a validated biomarker in AML and other leukaemia’s. We aim at employing biophysical and chemical biology approaches to validate quantitative and fast release of Lp with accurate spatiotemporal control in in vitro disease models. Finally, we will validate the deployment of the constructs through preclinical in vivo models of AML. We foresee broad applicability of the developed technology, which may have profound implications in drug discovery. Upon successful completion of this research program, we hope to yield a new targeted drug to treat AML patients with improved efficacy and reduced side-effects.

Keywords: antibody drug conjugates,5 lipoxygenase,lapachone,acute myeloid leukemia,bioconjugation
External Stimuli Triggered Self-assembly of Dynamic Nanomaterials (ESTIMABLeNANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The emerging interest in hybrid materials whose properties can be significantly changed in a controllable fashion by external stimuli (ES) is the result from their increasing potential applications in a variety of areas including energy conversion, drug-delivery systems, hybrid electronics and catalysis. The external control of self-assembling systems has attracted considerable interest, as it does not require additional components and triggering can be easily achieved in a completely remote manner where and when required. The main goal of this proposal comprises the development of multi-stimuli (i.e. light, electrochemical, temperature) responsive supramolecular systems based on semiconducting and metal nanoparticles (NPs) and their subsequent use in the reversible, controlled assembly of organic-inorganic architectures in water. This will be accomplished by employing one of the most promising self-assembly motifs based on the barrel-shaped cyclic oligomer of cucurbit[8]uril (CB[8]) that can bind within its cavity ES-responsive molecules, i.e. derivatives of viologen (MV) and/or photochromic second guest molecules displaying light-control binding affinity for a MV•CB[8] complex. In the first stage of the project a variety of NPs functionalized by ES-sensitive derivatives will be prepared, which will be further used as nanostructured building units for ES-triggered self-assembly/dissembly of supramolecular discrete NPs systems and complex organic-inorganic networks. The inherent part of the research will be characterization of properties and phenomena occurring within the obtained nanoparticulate assemblies. The initiatives of the project encompass problems across the fields of inorganic chemistry, host-quest interactions, self-assembly processes, materials science, as well as interface and colloid chemistry. The results of the project hold potential applications in materials science, energy conversion, drug-delivery systems, hybrid electronics and catalysis.

Keywords: dynamic nanomaterials,external stimuli,host guest systems,nanoparticles,self assembly,supramolecular chemistry
Modern Geospatial Practices for Ancient Movement Praxis (GeoMOP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-22
End date: 2020-01-21
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Ancient roads cross-culturally reflect motivations and needs behind social, economic, political and religious relations of past societies; they imposed spatial order on agricultural production, enabled transportation of bulk-goods, mediated hegemonic power, and facilitated urban fabric. Everyday actions of past individuals must have had contributed to the formation of roads. And, in return roads must have had sustained individual (and societal) connectivity. Therefore, considered not only as the container of action, but also the action itself, the road has much more to say on the ancient movement praxis. GeoMOP investigates Early Bronze Age roads (also called hollow ways) in Upper Mesopotamia. At this space-time continuum, the movement praxis of the political economy contributed to the formation of roads. In realization of this, GeoMOP will construct an exceptionally detailed typology of hollow ways. The methodology axiomatizes that variations in the volumes of ancient movement resulted in quantifiable differences in soil compaction which in return variably changed soil composition and structure. GeoMOP will explore these differences via satellite remote sensing under the sensor fusion paradigm. In following, an Agent Based Model will be constructed to estimate numbers of moving agents (e.g. herd animals and wheeled carts). Results of the study will far surpass the current archaeological knowledge on locations and dimensions of hollow ways —the container, and will build an analytical model for the ancient traffic —the action. In return, movement praxis will provide details of EBA political economy; including land ownership, urban-rural relationships, and nodes of economic complexity. In particular, GeoMOP will investigate questions, such as: if the spatial configuration and use intensity of roads can describe variations in economies and reflect conflicting economic interests of different social groups.

Keywords: satellite remote sensing,agent based modelling,sensor fusion,ancient traffic,hollow ways,early bronze age,upper mesopotamia
Towards a typology of Visigothic script: the Beatus British Library Add. 11695 and its potential for dating and localising Visigothic script manuscripts (ViGOTHIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The main aim of the proposal is to establish a point of reference for the analysis of Visigothic script, the primary carrier of Latin writing in the Iberian Peninsula from the 8th to the 14th centuries. To date, most palaeographical analysis of Visigothic script has been conducted using a traditional methodology and following heterogeneous criteria, which has led to subjective results difficult to share or evaluate. In contrast, my research will create a computerised database of quantitative data by applying a specially designed method, a starting point that will allow codices written in Visigothic script to be described, compared and placed in their socio-cultural context. Innovative techniques for digital analysis of manuscript sources that will be acquired in the host institution will allow me to gain new insights into the analysis of the script while opening new avenues of research by applying digital tools to its study. The knowledge thus generated will be of great practical importance for future palaeographical and textual research establishing criteria upon which advanced studies can build. It will offer a means of understanding the script, its manuscripts, and its cultural context. The study builds on the systematic analysis of one of the few codices written in this script that can be dated and geographically located with certainty: the copy of the Apocalypse of Beatus of Liébana kept at the British Library (Add. 11695). I aim to achieve six specific objectives: A) Manual palaeographical study: (1) to determine how many scribes intervened in the copy of the codex, their graphic characteristics, (2) evolution, and (3) cultural context. B) Digital palaeographical study: (4) to apply and evaluate computer-assisted techniques to the study of Visigothic script, (5) their viability and benefits, (6) to establish a point of reference for computerised analysis of Visigothic script codices by providing accurate graphic foundations to foster historical research.

Keywords: medieval palaeography,visigothic script,british library,codices,digital analysis
PROMOTING ENERGIESPRONG RENOVATIONS AND ONE-STOP-SHOP RETROFIT CONCEPTS IN HIGHLY EFFICIENT NZEBS IN ENERPHIT STANDARD, TO MAKE RENOVATION MORE RELIABLE, FASTER AND COST-EFFECTIVE (outPHit)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Austria,Germany,Spain,Germany,Bulgaria,Greece,France,Netherlands
Call: Towards highly energy efficient and decarbonised buildings (H2020-LC-SC3-EE-2020-1, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 2561729.36
EU funding (EUR): 2561729.36
Participants: 10
Project status: SIGNED

The outPHit project aims to support building owners and housing companies in performing reliable, quicker and more cost-effective deep retrofits. Working on and collecting findings from real refurbishment projects, outPHit will promote renovation concepts like the Energiesprong approach or one-stop-shop solutions, but in highly efficient quality to NZEBs in EnerPHit standard, to stakeholders among neighbourhoods, municipalities, financing institutions and the building supply chain. It will lay the ground for regional players, particularly SMEs, to enter the market as providers of innovative out-of-the-box solutions, either consisting of conventional renovation concepts or of highly efficient prefabricated systems. While the focus is on residential buildings, most of the proposed approaches will also apply to non-residential buildings, thus widening the scope to educational and office buildings.

Keywords: enerphit,deep retrofits,res implementation,pre fabrication,passive house principles,quality assurance,success monitoring,case study projects,certification schemes
Functional Improvement & Validation of next Generation Equipment - Pulsed Laser Deposition for High Volume Manufacturing of enhanced piezo thin film materials enabling 5G data communication (FIVE-G)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2020-12-31
Duration (months): 20.0
Total project cost (EUR): 2452500.0
EU funding (EUR): 1716750.0
Participants: 1
Project status: CLOSED

The next generation of mobile technology, known as 5G, offers enormous potential for businesses and the wider public as it will facilitate faster downloads, reduce latency and improve energy efficiency – crucial attributes to achieving the Internet of Things (IoT) and the use of mobile networks to connect and operate autonomous cars, remotely controlled industrial robots, telehealth systems, and smart city infrastructure. However, the technology and ability to manufacture the components that are crucial to 5Gs success are currently not at a level where this potential can become a reality at a cost that would make its widespread roll out viable. Without urgent investment in 5G component manufacturing Europe seriously risks being left behind and allowing the US and Asia to take the lead in this crucial technology. The Solmates team has taken their PLD technology from initial concept to commercial equipment installed at institutes such as Imec, EPFL and Sintef i.e. for low volume production and R&D uses. The processes that run on the equipment currently are positioned at TRL 6. Funding is required to further develop Solmates’ PLD equipment and processes and ensure they are ready for entering the 200mm 5G component market. The FIVE-G project will therefore focus on four objectives to bring PLD into high volume manufacturing: 1. Establish requirements of manufacturers and develop the technology to meet these. 2. Reduce particle inclusion to the level required for the identified 5G applications 3. Adapt Solmates' PLD to cluster manufacturing. 4. Establish a distribution agreement and prepare for launch The introduction of high volume manufacturing PLD will advance the market, by providing more reliable deposition that is able to meet the technical needs of a future 5G network at a cost and throughput that is truly market leading.

Keywords: material science innovations,nanomanufacturing,pulsed laser deposition,large potential for,growth,bulk acoustic wave filter
Asymmetric Photochemical Reactions in confined Chiral space (A-PREACH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The stereochemical control of a reaction is a crucial goal that spans numerous fields of research, ranging from drug discovery to materials science. In this context, photochemistry will play a key role, given the variety of transformations it can afford. In particular, supramolecular photochirogenesis, hence the control of the chiral outcome of a photochemical reaction afforded by the weak non-transient interactions between the guest and its chiral host, represents a promising yet not fully explored field. The aim of the proposal is to deepen the knowledge on photochirogenesis from a theoretical point of view and apply this knowledge to develop novel asymmetric photochemical protocols. This will combine the advantages of photochemistry (access to thermally not allowed reaction pathways and generation of high-energy intermediates among many) with the ones enabled by supramolecular host-guest interactions (such as the presence of a confined chiral space, the stabilization of reactive intermediates and the possibility to use the host itself as an antenna to excite the guest for the reaction to occur). The final goal of the proposal is represented by the use of chiral molecular motors to control the stereochemical information of the host. In this way, dynamic control of the enantioselective outcome of a (photo)chemical reaction will be achieved.
A Diffusion Maps workflow enabled by Neural Networks and Equation-free calculations for multi scale material and process modelling (DataProMat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Luxembourg
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

The ambition of this fellowship, hosted by Professor S.P.A. Bordas (UL), is to propose a nonlinear manifold learning framework, in particular to implement the Diffusion Maps methodology, enabled by “equation-free” calculations and Artificial Neural Networks, in the context of multi-scale materials and process modeling and design. The goal is to push the boundaries of the “Digital Twins” paradigm beyond the current-state-of-the-art and to establish a methodological framework that links macro-scale process parameters and conditions to properties of complex materials, in an effort to meet the current market-driven demands for efficiency, scalability, safety, sustainability and innovation. The proposed approach is based on the current trends in materials and process modeling, on which the host is in the best possible position to advise as a world leading expert. Effectively, the fellowship sets the stage for interdisciplinary integration: Starting from the requirement for a specific set of properties, we must be able to predict the appropriate material structure, its capabilities and limitations and to propose ideal processing steps that will enable large-scale production. In this context, machine learning in the form of Diffusion Maps will be implemented for dimensionality reduction aiming to the reach the maximum possible size compression. The equation-free approach will be integrated with Diffusion Maps, in order to efficiently explore the, typically large, parameter space and Artificial Neural Networks will be applied as a means of leveraging the abundantly available digitized images to “learn” the long-term dynamics of the material behavior.
Healthcare Encounters in Immigrants’ Everyday Lives (HEIEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

The main goal of HEIEL is to examine how Chinese immigrants in Italy perceive their bodies, manage their health, and experience the local healthcare system in the context of national austerity, rising anti-immigrant sentiments, and on-going political, social, and demographic transformations and how these perceptions and experiences affect their identity formation. This ethnographic study will be based on 12 months of fieldwork mainly involving in-depth interviews and participant observation in Bologna and Rome. It will provide a new bottom-up narrative of immigrant health amid ambiguous power dynamics in which immigrant subjects are simultaneously economically privileged and socially vulnerable. It is a timely research project that locates immigrant subjects' everyday healthcare practices at the intersection of their transnational migration process, dynamic political and social realities, and geopolitics. It is a comparative study that examines structural considerations and investigates how immigrants negotiate and choose among formal and informal healthcare providers in a multi-ethnic EU welfare state and why informal medical treatments are often preferred over formally legitimate and cheaper public services. It is a multi-sited ethnography of encounters that examines healthcare seekers' interactions with various types of healthcare providers, institutions, and authorities, which may affect their healthcare choices and practices. It is an interdisciplinary project at the intersection of anthropology, sociology of migration, and public health. This project will inspire healthcare and immigration policymaking, as well as contributing to theoretical debates surrounding immigrant health, as well as biopolitics and identity. The HEIEL will ultimately contribute to the ER’s career development plan of becoming a leading interdisciplinary scholar of Chinese migration to Europe.

Keywords: immigrant health,informal medical treatment,integration of immigrants,immigrant everyday life,healthcare practice,ethnic encounters,social inclusion and exclusion,ethnography of encounters