Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Zygotic Cell Fate and Parent-Biased Gene Expression in Fission Yeast (ZygoticFate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-12-01
End date: 2026-11-30
Duration (months): 72.0
Total project cost (EUR): 1702705.0
EU funding (EUR): 1702705.0
Participants: 1
Project status: SIGNED

As two gametes fuse, the newly formed zygote immediately represses mating, to prevent polyploid formation, and triggers the developmental program that gives rise to a new individual. My work showed that zygotes of fission yeast and higher eukaryotes bare striking similarities, and here I propose to use this powerful model system to explore the basic mechanisms of gamete-to-zygote transition. Working in fission yeast, where gametes and zygotes are well-defined and accessible to outstanding plethora of experimental approaches, will show how different regulatory mechanisms synergize to execute this key cell fate switch. Our first aim explores zygotic regulation of gene expression and mating blocks. First, to show how zygote-specific signaling propagates, we will identify its targets using biochemical screens. Second, we will analyse how zygotes alter gene expression. High-throughput sequencing will show transcriptional dynamics and genetics approaches will test its regulation and relevance. Third, we will combine microscopy and genetics to reveal the workings of fungal re-fertilization blocks. Our second aim explores roles and regulation of the parent-biased allele expression in fungal zygotes that I recently discovered. While biochemical and sequencing-based screens will identify genes asymmetrically expressed from parental genomes, genetics strategies will test their roles. A structural biology workpackage will show how a simple homeodomain transcription factor drives the bias between parental genomes. Similarities between zygotes of fission yeast and higher eukaryotes hint to the relevance of our work for other developmental systems. By understanding fungal blocks to re-fertilization, which have been previously completely overlooked, we may identify their conserved principles, as increasingly evident for other sexual processes. Finally, exploring the bias in expression of parental alleles in yeast may help explain its recurrence in distant plant and animal lineages.

Keywords: cell fate,gamete to zygote transition,re fertilization blocks,parent biased allelic expression,homeodomain transcription factors,micropeptides
The value of mothers to society: responses to motherhood and child rearing practices in prehistoric Europe (VAMOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1499680.0
EU funding (EUR): 1499680.0
Participants: 1
Project status: CLOSED

Analysing the link between reproduction and women’s social status, this project explores social responses to pregnancy, birth and childrearing from the late Neolithic to the late Iron Age (c.3000-15 BC) through case studies in central Europe. Motherhood and childrearing, often seen as natural, mundane and inevitable parts of women’s lives, are also cultural and historically contingent practices that build the foundations of societies. Exploring the value of mothers to society will aid in understanding important long-term developments such as social stratification, increasing population density and the entrenching of gender roles during the three millennia under investigation. Bringing together the latest developments in archaeological science, including palaeo-pathology, ancient DNA and isotope analyses, with innovative interpretative approaches, this project will explore if all women were expected to become mothers, highlight alternative lifeways, evaluate risks and consequences of becoming a mother and analyse the social value of reproductive success. It is the first study that aims to systematically predict the probability of whether or not a woman has given birth using palaeo-pathological markers combined with individual age information and population-specific demographic data. It will contextualize the findings with an in-depth status analysis of women’s graves. Graves of pregnant women, double burials of women and children as well as infant burials will provide further data. The study extends to childrearing (care, feeding, but also abuse, neglect and infanticide) and explores how children were treated after death for insights into their significance. Current political discourses about mothers in society and workforce frequently refer to ‘natural’ and ‘ancient’ childrearing practices. This project will contribute significantly to our understanding of motherhood and counter naive narratives of childrearing in prehistory with science-based information.
Improving and professionalizing the Health NCP service across Europe. (HNN 2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Coordination and support actions
Countries involved: Austria,Israel,Germany,Italy,Spain,Switzerland,Belgium,Croatia,Greece,Poland,France,Portugal,Portugal,United Kingdom
Call: National contact points (H2020-HCO-2014, 2014)
Start date: 2014-12-01
End date: 2019-11-30
Duration (months): 60.0
Total project cost (EUR): 2082673.75
EU funding (EUR): 1999548.75
Participants: 17
Project status: CLOSED

Health NCP Net 2.0 aims at improving and professionalizing the NCP service, thus achieving a more consistent level of NCP support services across Europe with the final goal to better support applicants and raise the average quality of proposals submitted. HNN 2.0 builds upon the experience and results of the previous Health NCP Net project with the objective of responding to the new challenges that the “Health, Demographic Change and Wellbeing” NCPs face in the new programme Horizon 2020, such as the broadened thematic scope of the Societal Challenge 1, and the enlarged mandate of the “Health” NCPs. An objective of the HNN 2.0 project is to satisfy the needs and priorities of all different types of NCPs, notably newcomers, NCPs with fewer resources, NCPs from EU-13 and NCPs in Third Countries so as to face the challenge of the current heterogeneity of the network The enlarged mandate of “Health” NCPs and the holistic focus of H2020 imply that NCPs need to create expert knowledge and look for it outside the SC1 Network by having a holistic approach and liaising and collaborating with other support structures, projects and programmes. HNN 2.0 will therefore have a real structured coordination with the other NCP and support networks such as Ideal-IST, EEN and Fit for Health 2.0, where collaboration for joint activities like training courses, meet and exchange workshops and brokerage events is established. Main tools towards the objectives: - support and information materials - comprehensive training programme - mentoring programme (staff exchanges, mentoring programme for EU-13, twinning with the European Commission) - Meet and Exchange workshops with NCPs from other disciplines - system of email alert for NCPs about research funding and related policies - information and communication hub for SC1-NCPs (easy access to information and services , exchange of information and opinions between SC1-NCPs) - International brokerage events

Keywords: health research,ncps,societal challenge 1,horizon 2020,training,mentoring,brockerage events,networking,information materials
First effective targeted therapy for T-cell acute lymphoblastic leukemia (T-ALL) and other NOTCH pathway driven cancers (CB-103)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive NOTCH-dependent cancer that affects the blood and bone marrow especially in children aged 0-14 years, and currently has no effective cure. T-ALL accounts for about 25% of the total cases of Lymphoblastic Leukemia (ALL); additionally, an estimated 250,000 people are afflicted by NOTCH-dependent cancers every year. Chemotherapy, the standard-of-care treatment for T-ALL, can reduce tumor growth, but it is ineffective at killing the cancer stem cells that drive tumor progression. Moreover, it can lead to adverse toxicological effects as a result of off-target toxicity, as the drug cannot discriminate between healthy and cancerous cells. Small molecule drugs help to solve this issue thanks to their high efficiency in targeting tumor cells. Cellestia may have found the answer. Its novel approach targets a tumor development pathway, the NOTCH, which play crucial oncogenic roles in tumorigenesis, tumor expansion and survival. By inhibiting the NOTCH signaling in its most downstream part, Cellestia’s small molecule compound, CB-103, blocks the problem at the roots (i.e. specifically at the level of the NOTCH transcription complex) stopping cancer cells growth and survival. Pre-clinical results show CB-103 to have a high therapeutic index relative to conventional cancer drugs. Most importantly, it significantly prolongs survival rates (median improvement of 75%) with no adverse side effects or dose-limiting toxicity (DLT). Results indicate it may have benefit for other cancers too – any in which NOTCH pathway is highly activated, including forms of leukemia and other cancers such as lung, breast and colorectal. The Phase 1 project will be focused on establishing a complete and scalable supply chain, verifying the business model and commercialization strategy, planning new collaborations and partnerships, including the ones to implement the next clinical trials stage.

Keywords: cancer,targeted therapy,notch inhibitor,orphan drug,drug development,small molecule
Monitoring the Bioeconomy (BioMonitor)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Germany,Spain,Germany,Slovakia,Belgium,Finland,Sweden,Latvia,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Towards a method for the collection of statistical data on bio-based industries and bio-based products (H2020-BB-2017-2, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 5983857.52
EU funding (EUR): 5983857.5
Participants: 19
Project status: SIGNED

The overall objective of the Monitoring the Bioeconomy (BioMonitor) project is to establish a sustainable data and modelling framework for the bioeconomy. This will be achieved by developing and implementing a data and modelling framework that is effective (supported by a stakeholders’ platform) and robust (implementable in existing systems of statistical and customs offices, laboratories and industries). The framework will enable quantification of the bioeconomy and its economic, environmental and social impacts in the EU and its Member States. Interlinks with current CEN standardisation work related to bio-based products will be established from the outset of the project. The contributions of BioMonitor are threefold. First, the project will close the data gaps in measuring the bioeconomy by updating and enhancing currently used data sets. BioMonitor will assure the inclusion of new emerging bio-based products and industries by developing appropriate tools and strategies. Second, the improved data will be used to enhance established and new modelling tools, linked in the BioMonitor toolbox, to guide industries and governments responsible for the execution of consistent, coherent and longer term strategies with desirable consequences for multiple objectives. Third, a BioMonitor platform for stakeholder engagement and training will be created to design, test (by industry-based and country-level case studies) and disseminate results of the improved datasets and modelling capacity. The platform will inform the formulation of strategies and policies directing the bioeconomy to achieve its economic, environmental and social policy objectives according to the EC Bioeconomy Strategy and Action Plan. The awareness about the importance of measuring the bioeconomy within the industry will be raised through tailored training on bioeconomy standards and measurement of sustainability indicators targeted towards SMEs within the sector.

Keywords: bioeconomy,monitoring,methodology,data gaps,stakeholders
An emancipation device to increase mobility for disabled people (SIRENA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TGR is an Italian company with more than 35 years of tradition and innovation in the field of stair climbers. During our activity more than 50,000 people have benefit of our products improving their condition. With Sirena project we aim to be a technology and market leader in the mobility sector improving the living conditions of millions of citizens in Europe and around the world. Sirena is a technological breakthrough offering a universal solution able to climb stairs for people with limited physical abilities. For the first time the market will see a stair climber able to: 1) adapt to any type of stairs and steps; 2) be quick and comfortable, avoiding the nuisance vertical movements that characterize all other competing products; 3) be easily transported anywhere. We will help people -disabled, elderly or anyone who could find difficult or too tiring climbing stairs- to break down the boundaries of their isolation. We will reach them throughout our consolidated commercial network and with new commercial channels: disabled associations, nursing homes, pharmacies etc. The feasibility study will provide an assessment of the viability of our established technical objectives and a marketing analysis to find the best strategy to disseminate and exploit the results. Special care will be put on the evaluation of eventually existing related patents and to protect our unique mechanical climbing system. As TGR is a solid and well established company, Phase 2 will be funded through its current profit. With Sirena everyone will obtain benefits: TGR and the satellite activities will greatly expand their business opportunities and turnover, private buildings will not require expensive infrastructures to overcome architectonical barriers, meaning great savings for the landlords and avoiding possible conflict situations, but most importantly, disabled and elderly will be more integrated into the society finally accessing to a fully developed social life.

Keywords: mobility,stair climber,comfort,universal solution,wheelchair,architectonic barriers,disability,disabled
Modelling the Impact of Human Behaviours on Infections Spread (IMMUNE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1986437.0
EU funding (EUR): 1986437.0
Participants: 1
Project status: SIGNED

Aim: The IMMUNE project will provide a ground-breaking interdisciplinary modelling framework that will explore the dynamics of human behavior on infections’ spread, through the lens of social sciences, integrating risk perceptions on diseases and vaccines, (mis)information campaigns, social peers influence and digitalisation. Background: Vaccines represent one of the most significant, cost-effective and safe public health interventions ever introduced. However, vaccine hesitancy has become alarmingly widespread over the last two decades, especially in Europe where vaccine refusal has steadily increased and serious outbreaks of vaccine preventable diseases have re-emerged. Method: A combination of quantitative approaches and research methodologies will be used to extend the current state-of-the-art epidemiological models. Digital records on individuals’ use of the Internet and social media will be analysed to study the interplay between health communications, risk perception and vaccine uptake in different contexts. Experimental and field surveys will be conducted in three selected EU countries to generate data on individuals’ social interactions, both physical and virtual. Agent-Based and mechanistic compartmental models will be developed to unravel the complex relationship between the determinants of human behaviour, vaccination decision and infection spread. Impact: The IMMUNE project provides a step forward in the understanding of the relationship between human behaviour and the demand for vaccines, and how these two aspects are intertwined with the way infections spread in our communities. The proposed activities will integrate different perspectives and strategies in a novel and comprehensive framework where human contagion is at the centre of a multidimensional approach that stands at the intersection of epidemiology, demography, sociology, social psychology and public health.

Keywords: infection,infectious disease,vaccines,vaccination,vaccine hesitancy,vaccine refusal,immunisation,human behaviour,population dynamics,health,epidemiology,demography,modelling,agent based model,digitalisation,social media,computational epidemiology,digital demography
Fast and accurate enantiomeric and chemical analysis (FastEE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France,France
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Chiral molecules exist as two forms, called enantiomers, which are mirror images of each other but which are not superimposable. Living organisms are built upon chiral elementary blocks. Biological processes can thus be extremely sensitive to chirality. Two enantiomers can have different smells or tastes. More critically, a chiral molecule can have healing properties while its mirror image is a poison. This makes the measurement of enantiomeric excess (EE), which quantifies the relative composition of the two images in a mixture, crucial for many industrial sectors: fragrance and food industry, pharmaceutics, agrochemistry. To improve product quality, lower health risks, and optimize processes to reduce chemical waste, it would be necessary to monitor EE continuously. Yet, this task is currently impossible because there is no fast and accurate enough EE measurement method. The FastEE project aims at solving this issue by using a new physical process which is extremely sensitive to chirality. By investigating the photoionization of chiral molecules by elliptically polarized light, we found out that the angular distribution of the ejected electrons carried rich information on the ionized molecules as well as their enantiomeric purity. Continuously modulating the ellipticity of the ionizing radiation while recording images of the photoelectron distribution enables the chemical composition and EE of mixtures to be followed in in real-time. FastEE aims at: (i) designing a demonstrator instrument using this method, optimized for an applicative environment, (ii) optimizing the method for the accurate analysis of complex chiral mixtures in real-time, (iii) investigating transfer and commercialization strategies. After completion of the three phases, we will be able to offer a new solution (instrument and methodology) for chiral analysis, enabling fast and continuous measurements with excellent accuracy - which is not possible with current technologies.

Keywords: enantiomeric excess measurements,chiral analysis,photoelectron circular dichroism