Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cooperative Multipoint Transmission for Interference Coordination (COMIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 209248.3
EU funding (EUR): 209248.3
Participants: 1
Project status: CLOSED

COMIC aims at defining Cooperative Multipoint (CoMP) techniques focused on interference mitigation based on efficient scheduling design and beamforming. These techniques will be divided into two groups. In a first phase a set of ideal techniques will be proposed assuming a perfect knowledge of the system state (users’ location, speed, bit error rates, etc.). A huge number of variables will be taken into account, thus increasing the complexity of these optimization problems. This group of techniques will be used as a reference to test the performance of a second group of more realistic techniques defined in a second phase. For these techniques, not all variables will be known and, moreover, there may be errors in measurements. Comparing the first and second group, the best realistic technique will be identified depending on their behaviour, errors impact and complexity. The design of all these algorithms will be carried out at Carleton University (CARLETON) during the first two years of fellowship. The mathematical requirements for completing this task compel to closely work with an expert group in telecommunications and applied mathematics like CARLETON. During the return phase at the Polytechnic University of Valencia (UPVLC), COMIC will focus on implementation aspects of the best algorithms. Therefore, COMIC not only aims at studying theory aspects but also at evaluating practical implementation problems. Hence, all conclusions arisen from the outgoing phase will be experimentally validated using the simulation and radio-over-fiber platforms available at UPVLC. The interdisciplinary aspects of the outgoing and return phases correspond with the expertise of each host. Thanks to the theoretical and practical aspects that will be studied in COMIC, the results of this project are expected to have a huge impact.

Keywords: wireless systems,networks beyond 3g,cooperative multipoint transmission,interference coordination
Active liquid crystal colloids (ACTOIDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 180603.2
EU funding (EUR): 180603.2
Participants: 1
Project status: CLOSED

ACTOIDS aim at a vibrant multidisciplinary scientific field of complex soft matter materials, intertwining fundamental questions of activity generated dynamics and technologically attractive self-assembled structuring of colloids in complex fluids. We propose novel materials - active liquid crystal colloids – which possess a unique combination of active, self-propelled, material flow and the discrete ordering of inactive colloidal particles. The subtle coupling of the active flow to the particle dynamics suggests strong potency for interesting material characteristics and applications, such as particle-controllable microfluidic flow-patterns, self-assembly of colloidal structures by material flow, and controllable steering of the flow by external fields. The questions raised range from fundamental and applied material science to transport in living cells. The materials will be approached by continuum mesoscopic modelling based on generalized liquid crystalline dynamics, combined with collaborative experiments. The wide outreach of the proposed research will offer training for the fellow in diversity of skills and competencies building upon his scientific excellence. The fellow will train also on non-scientific issues, including communication and presentation skills, intellectual property rights, ethical issues, language proficiency and cultural awareness. ACTOIDS will be implemented at University of Oxford, an experienced host institution, renown for its ingenuity and highest scientific standards. Mobility of the fellow will create cohesion and institutional connections at bi-lateral and Community level. Strong ties with European and global scientific community, will put the fellow at the cutting edge of the ‘frontier research’ as well as create links to commercialise high-tech research results.

Keywords: natural sciences,activity,liquid crystals,colloids,flow,self-assembly,micro-fluidics
Rational Decision-Making in Adaptation to Climate Change (CLIMADAPT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 173403.2
EU funding (EUR): 173403.2
Participants: 1
Project status: CLOSED

Climate change is considered one of the most severe challenges facing humankind. Warming of the climate is expected to have profound global impacts, not only on the Earth as a physical system, but also on the well-being of humans, and on societies and economies. Two fundamental policy approaches exist to reduce the environmental, economic and social threats posed by climate change: mitigation (greenhouse gas emission reduction) and adaptation. Both policies involve significant theoretical and policy challenges that need to be addressed to secure the development of efficient and well-advised climate strategies. The overall aim of this research project is to improve European climate policy by addressing a set of decision theoretical and ethical questions that arise as society adapts to climate change. More specifically, the research objectives of the proposal are to: i) provide a decision theoretical analysis of the timing of different climate adaptation measures, ii) investigate a set of philosophical problems associated with the valuation of future consequences of climate adaptation policies, and iii) assess the usefulness of multi-objective decision support tools in the management of goal conflicts arising in the context of climate adaptation. The project will be carried out at the Department of Philosophy at the London School of Economics and Political Science (LSE), which is currently ranked number one in the philosophy of social science according to the Philosophical Gourmet Report. An important part of the research will consist in analysing different policy approaches to climate adaptation in Sweden and the UK, the understanding of which will make a strong contribution to future EU adaptation initiatives and strengthen European competitiveness in the field of philosophically informed climate policy research.

Keywords: climate change,adaptation,decision-making,rationality,ethics,time frame,discounting,future consequences,goal conflicts,multi-criteria analysis
Studying the dynamic structural interactions between neurons and glial cells at synapses of the central nervous system by using novel technical approaches (DMANDYB ASTROMORPH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 181970.8
EU funding (EUR): 181970.8
Participants: 1
Project status: CLOSED

Neuron-glial communication in the Central Nervous System is fundamentally important for many brain processes including synaptic transmission and plasticity. Intracellular calcium signaling appears to be a key event occurring in astrocytes, a subtype of glial cells, during their interactions with neurons. Astrocytes extend fine processes to enwrap synapses and form tripartite complexes with neuronal synaptic structures. The morphology of both neuronal and glial processes shows rapid and continuous structural remodeling in the hippocampus. These physical modifications are likely to have a significant functional impact upon neurotransmission and suggest that the remodeling of astrocytic morphology might be crucial for the dynamic regulation of the synapse and its microenvironment. Here, we will determine how neuronal activity regulates the morphological interplay between astrocytic processes and synapses. We will also investigate a new role for the astrocytic calcium excitability in controlling astrocytic process motility. In situ studies on neuron-glia interactions are technically challenging due to the difficulty of obtaining cell specificity and accurately reproducing the complex calcium excitability of astrocytes. To overcome those difficulties, new tools and approaches are needed. The present proposal will transfer novel strategies based on molecular tools, which have been recently developed by the applicant in his present position at the third country, into the host institution. The applicant will bring his knowledge on glia into a host laboratory with expertise in the field of neuronal synaptic morphology and plasticity. We believe that a novel experimental approach will allow answering previously inaccessible questions and help elucidate the role of neuron-astrocyte morphological interactions in regulating synapses that may be important for understanding synaptic physiology, behavior and brain disease.

Keywords: biological sciences,neuroscience,hippocampus,synapse,astrocytes,morphology,neuron-glia interaction,viral gene delivery,channelrhodopsin,intracellular calcium,fluorescent microscopy,plasticity
Glypican5-supported endocytic control of BMP4 signaling. (GPC IN BMP SIGNALING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 159100.0
EU funding (EUR): 159100.0
Participants: 1
Project status: CLOSED

Increasingly, the glypicans, major membrane proteins that supply heparan sulfate at the surface of cells, emerge as essential for the reception and dissemination of morphogenetic signals. While the best recognized role of endocytosis in signaling is to down-regulate the signal by sending the receptor and/or the ligand to degradative compartments such as lysosomes, it has now become clear that endocytosis also contributes to activation of signalling. In this project, we propose to explore the importance of glypicans for mechanisms of endocytic/exocytic trafficking and fine-tuning of signalling. We suspect that, by associating with specific protein sorting and trafficking machineries, glypicans control the formation of distinctive ‘signalling endosomes’, involved in the transcytosis of HS-cargo and its recycling to the cell surface, influencing what signal-transduction machineries are activated, where they are activated, and for how long. This working hypothesis is explored, concentrating on the effect of Glypican-5 on Bmp-4 signaling, in vitro, by cellular and biochemical assays, tracing glypican and glypican-interacting proteins, and by functional interference, using siRNA, and in vivo, in zebra fish embryos, using the injection of anti-sense morpholinos and mRNAs. Using these combined and integrated approaches in test tubes, cells and model organisms, we expect identifying novel mechanisms of vesicular trafficking that are important for development, developmental disorders, and acquired disease. In general, this project proposed will support the career development of the researcher by enhancing her competence diversification through a complete training. This fellowship is an opportunity for the applicant to attain a leading independent position.

Keywords: health sciences,proteoglycan,glypican,bmp4,trafficking,recycling,signaling,endosome,exosome,zebrafish,membrane organization
New Methodology for the Synthesis of Bioactive Pyrrolidines and Pyrrolidinones (BIOPYRR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2011-08-31
Duration (months): 18.0
Total project cost (EUR): 130430.6
EU funding (EUR): 130430.6
Participants: 1
Project status: CLOSED

The development of new and efficient methodology for the synthesis of privileged structures of biological importance is an ever important goal for organic chemists. Natural products continue to provide a source of such important chemical entities for the treatment of human diseases. In particular the pyrrolidine and pyrrolidinone motif are biologically privileged structures which are present in over 9000 natural products, many of which possess important biological activity. The aim of this proposal is to develop a range of new transition metal mediated and transition metal catalysed synthetic methodologies for the efficient synthesis of pyrrolidines and pyrrolidinones which will be applied to the total synthesis of a biologically important natural product which contains a lactone-pyrrolidinone as its core heterocyclic motif. The developed synthetic methodology will also be applicable to the synthesis of a wide range of biologically active natural product targets.

Keywords: organic chemistry,organic synthesis,methodology,pyrrolidines,pyrrolidinones
Enabling the interoperability of cytometric data – a novel bioinformatics approach for revealing systems level understanding of cell cycle dynamics (CELLULAR INFORMATICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-04-01
End date: 2012-09-30
Duration (months): 30.0
Total project cost (EUR): 279783.7
EU funding (EUR): 279783.7
Participants: 1
Project status: CLOSED

The fellowship addresses a growing area of the life sciences interests of the EU community – understanding biological processes at the system level. Availability of high-quality quantitative data constitutes a bottleneck in this area and the fellowship addresses a specific problem. Ongoing efforts to converge genomic and proteomic data aiming to enlarge the systems view through bioinformatics. There is increasing recognition that at the cellular level heterogeneity and dynamic changes are complicating factors demanding cellular informatics solutions. This is highlighted in cell-based analyses, using cytometry platforms, where informatics solutions are limited and bespoke. The scientific objective of this multidisciplinary fellowship is to permit a seamless exchange – interoperability - between data derived from cellular analysis technologies ranging from fluid flow systems to advanced imaging - so that such data is within accessible structures for hypothesis testing. This will be achieved by permitting temporal links between dynamic (eg timelapse imaging) and static (eg flow cytometry or high content screen) measurements. Outcomes are applicable to multiple areas - our focus is on cancer biology and the cell cycle - exploiting data originating from existing cell analysis platforms and novel molecular reporters. The biological challenge is to study the pharmacological modulation of the mammalian cell cycle. The bioinformatics challenge is to develop a coherent infrastructure for revealing subtleties in drug responses. The fellow will spend altogether 18 months at Broad Institute USA (outgoing) and 12 months at Cardiff (reintegration). Work packages will address the design and development of the infrastructure for cytometry data interoperability and interpretation, utilising existing data acquisition tools and real experimental data sets developed at these host institutes. Future plans include the dissemination of research and roll-out to the wider community.

Keywords: cell cycle,cancer,bioinformatics,cytometry,data interoperability,multidisciplinary collaboration,systems biology,drug discovery
Asymmetric Organocatalysed Diels-Alder/Fragmentation Cascades (ASODAFCA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

The intramolecular Diels-Alder reaction of 2-amino-furan derivatives is a powerful tool for the rapid synthesis of complex polycyclic compounds. The reaction has been used as a key step in the preparation of biologically relevant molecules such as natural products and pharmaceuticals. However, despite the great potential of this kind of Diels-Alder reaction, no catalytic asymmetric version has been reported so far. During this Fellowship we wish to develop new, asymmetric, organocatalysed cyclisation reactions of substrates bearing an amino-furan derivative and an enone functionality. In the presence of primary or secondary chiral amines, alpha,beta-unsaturated compounds undergo LUMO-lowering activation via the reversible formation of transient iminium ions. The concept of our proposal is to apply the iminium ion activation of enones to induce asymmetry in the Diels-Alder cycloaddition with appended amino-furan moieties. Furthermore, it is known that stereocenters at the gamma-position of enones can be racemised in the presence of primary/secondary amines via the formation of dienamine intermediates. Therefore, a further target will be the development of a tandem transformation involving a Dynamic Kinetic Resolution (DKR) and an Intramolecular Diels-Alder reaction of 2-amino-furan derivatives with enones presenting a stereogenic centre at the gamma-carbon. This would constitute a new, powerful and broadly applicable organocatalytic asymmetric strategy to target, in the first instance, alkaloids of the Daphniphyllum family. In particular, we are interested in the enantioselective synthesis Daphniyunnine D (IC50 0.6 μM against A549 cancer cell line). The Fellowship will therefore involve different branches of modern chemical research, such as asymmetric methodology, catalysis, target oriented synthesis of bioactive compounds.

Keywords: physical sciences,organic chemistry,homogeneous catalysis
Dynamic study of shape and force generation by clathrin polymerization onto lipid membranes in vitro. (CLATHPOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 176065.2
EU funding (EUR): 176065.2
Participants: 1
Project status: CLOSED

The “CLATHPOL” project focuses upon a fundamental aspect of Clathrin Coat Vesicle formation. The critical biochemical (clathrin/adaptor interactions, membrane composition) and physical parameters (deformation forces, role of pre-induced curvature) controlling the shape and polymerization rate of clathrin coats will be determined and the forces applied on the membrane by clathrin polymerization will be measured. The “CLATHPOL” project will investigate the complex interactions driving clathrin coat assembly by developing improved bio-mimetic model systems to capture the complexity of biological membranes. The kinetics of clathrin polymerization and the dynamics of membrane shape generation will be studied by fast videomicroscopy using a membrane sheet assay to track coat formation on membranes exposed to various mixtures of clathrin and adaptor proteins. Membrane deformations will also be visualized using fluorescently labeled proteins. In the second stage, the forces on the membrane caused by clathrin polymerization will be measured using Giant Unilamellar Vesicles (GUVs). The membrane tension of the GUVs will be modulated by micropipette aspiration while membrane rigidity will be varied by changing lipid composition. Finally, the influence of membrane curvature on the dynamics and structure/geometry of the clathrin lattice will be determined using nano-patterned substrates with controllable and well-defined surface curvature. Membrane binding and lattice formation will be followed by Total internal reflection fluorescence (TIRF) microscopy and high speed atomic force microscopy.

Keywords: biophysics,membrane biophysics,clathrin,adaptors,clathrin polymerization,lipid membrane,rigidity,tension,membrane curvature,model systems
Functional and genetical characterization of Ccbe1, a novel regulator of lymphangiogenesis (CCBE1 AND LYMPHATICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 161248.8
EU funding (EUR): 161248.8
Participants: 1
Project status: CLOSED

Ccbe1 has recently been identified as an essential regulator of lymphangiogenesis in zebrafish. Loss of function of this secreted factor leads to a failure of lymphangioblast budding and a complete lack of lymphatics. Intriguingly, mutations in human CCBE1 are causative for a congenital lymphatic malformation disease, termed Hennekam syndrome (HS). The main goal of this project is to understand the function of Ccbe1 in development and disease. Firstly, since the mode of action of Ccbe1 is completely unknown, we will focus on identifying interaction partners for this secreted protein by three different approaches: (1) I will test the interactions between Ccbe1 and one potential binding partner identified in a yeast-two-hybrid assay (2) I will perform IP experiments with myc-tagged Ccbe1 protein, followed by Mass Spectrometry for protein identification. (3) I will analyze an additional gene causing HS, identified in the human clinic. For all three approaches, candidate genes will be validated further through expression pattern analysis in zebrafish and mouse, in conjunction with functional tests through morpholino injections and co-IP studies with Ccbe1 in zebrafish. Secondly, I will focus on analyzing Ccbe1 conditional mouse knock out models. Using inducible and constitutive tissue specific Cre-recombinase lines, I will identify those tissues and cell types which require Ccbe1 activity for their normal physiological functioning. Particular attention will be on the role of Ccbe1 in those organ systems that are affected in HS patients, i.e. the lymphatic system and the brain. Furthermore, the inducible knockout of Ccbe1 in adult mice will answer the key question whether Ccbe1 is also required during adult stages for lymphangiogenesis. CCBE1 is one of very few genes known to be essential for lymphatic function. The proposed project will help to better understand the mode of action of this recently identified, critical factor in human lymphangiogenesis.

Keywords: natural sciences,developmental biology,lymphangiogenesis