Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From co-transcriptional splicing kinetics to the evolutionary impact of exon and intron definition (EvolSpliceKinetics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

The need to preserve correct splicing is a major source of constraint on sequence evolution. This includes selection on the splice sites as well as on regulatory elements in exons and introns. Are all exons and introns constrained similarly by splicing related pressures? This is a crucial problem not only for understanding genome evolution but also for predicting where disease-causing mutations occur. Any variation in the prevalence of splicing information most likely reflects mechanistic variation in how the splicing process unfolds at different introns. Notably, it is often assumed that the relative importance of intronic and exonic splicing information depends on whether the splicing machinery recognizes introns or exons as the initial unit. However, this common model has never been tested directly because it is currently not possible to investigate splicing mechanism at this level of detail genome-wide. Existing studies on the distribution of splicing information are therefore based on proxies of unclear mechanistic significance, such as intron size. My host lab has developed a nascent RNA sequencing technique that allows unprecedented insight into splicing dynamics transcriptome-wide. They have recently applied this method to Drosophila melanogaster, a species thought to use a diversity of splicing strategies. I propose to use this data, combined with a machine learning approach, to conduct the first genome-wide study into exon and intron definition based on direct kinetic evidence. I will then use population genetics methods to determine how the prevalence and strength of selection on different types of splicing information covaries with splicing dynamics.

Keywords: splicing,sequence evolution,exon and intron definition,population genetics,machine learning
Zooarchaeology and Mobility in the Western Mediterranean: husbandry production from the Late Bronze Age to Late Antiquity (ZooMWest)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-01-31
Duration (months): 58.0
Total project cost (EUR): 1199319.0
EU funding (EUR): 952559.36
Participants: 2
Project status: CLOSED

Human survival and success is substantially determined by the ability to move across the landscape and adapt. Consequently, ‘mobility’ is a crucial topic in historical and archaeological research. To overcome the seasonal scarcity of food and the related over-grazing of pastures, it is essential for animal husbandry to move across territories. However, the decision to allow or deny rights of way to mobile people and livestock depends on political judgements. How might these shape animal husbandry production, and society? The period between the Late Bronze Age and Late Antiquity in the Western Mediterranean witnessed the development of complex societies with a high territorial component, the Roman conquest, and the decline of the Western Roman Empire. Animal husbandry reflects human decisions regarding the management of resources, and the study of livestock rearing in specific geographical locations is possible through the isotopic analysis of ancient animal teeth. Consequently, we can analyse whether the nucleation of power occurring during the Bronze and Iron Ages, the centralization in Roman times and the later re-fragmentation in Late Antiquity transformed animal husbandry production. Crucially, we can then understand how political systems and decisions shaped human mobility through investigating animal production. ZooMWest brings together isotopic chemistry, ancient DNA, zooarchaeology and geospatial analysis through four related work packages. Other than elucidating long term debates in archaeology –did transhumance exist in prehistoric Europe?–, this multidisciplinary and innovative project will create an open-access database of strontium and oxygen stable isotopes of the Iberian Peninsula and Italy. This database will enable us to refine geographic provenance to any discipline assessing the origin of matter, including geology, forensic studies, and the alimentary industry, as strontium and oxygen are present in many molecules, including organic tissues.

Keywords: zooarchaeology,geographic information systems gis,stable isotopes,ancient dna
The Rhyme: Theory and History of the rhyme in Italian and European literature (RTHRIEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The objective of the present research proposal is to outline a general theory of the rhyme which might fully explain the meaning of such a device, filling a very significant gap in metrics and literary theory. The research has already started with a forthcoming article and a 3,5 months DAAD scholarship at the Freie Univestität Berlin: the present research proposal aims at developing it into a monograph. The already written chapters concern the general theory (1-Figurative function of the rhyme; 2-Outlines of a semiotics of the rhyme) and the intertextual implications of the rhyme. The new chapters to be written from scratch will concern: 1) the outlines of a general history of the rhyme (still lacking), from its origins up to the 20th Century; 2) the analysis, from the outlined theoretical perspective, of the main traditional rhyming structures (terzina, ottava, sonetto, canzone etc.) and their significance to the text; 3) an account of the partial revival of rhyme in present-day literature, in the attempt to answer the question if rhyme is still possible today and to what extent; 4) the relation of rhyme and psychoanalysis; 5) the question – hardy ever dealt with – of the relation of rhyme and rhyme patterns to music; 6) a survey of the use of rhyme in non-literary text, such as nursery rhymes, pop music lyrics, advertisements, to check the validity and the limits of the theory beyond literature and also to address a wider audience; 7) the outline of a “philosophy of rhyme”, examining the aesthetical conception implied by such a device; 8) an analysis of the use of the word “rhyme” when it appears in rhyme producing a metadiscourse in metrics and poetics. Besides the monograph, an important result will be the development of a refined rhyme-search software for digitized text corpora. The research results will be disseminated also through the web (wikies, websites, high-profile literary blogs) and through participation in workshops and international conferences.

Keywords: rhyme,theory of literature,metrics,stylistics,rhetoric,semiotics,comparative literature,history of literature,intertextuality,psychoanalysis,aesthetics,music theory,advertising
Eco-innovative, frameless wood window with premium design, highest energy saving performance and maximum open area (W2C)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

We, the consortium responsible of W2C, composed by WECO and VIJO will place in the market a triple-glazed, high-performance insulating wood window named W2C “Window to See”. Its unique design has been patented and has received two international recognized awards (Red Dot Award 2015, Architect’s Newspaper ´15). W2C will be the first window in the market that combines the strict energy-saving standards demanded by the Passive House Institute and a frameless design that maximizes the window´s open area. It is oriented to the niche growing market of “Passive Housing”- highly energy efficient buildings-, offering an alternative to current thick framed windows. Its price is 15% cheaper that the average price of the references in this segment and the lighter structure allows us to offer larger sizes, up to 6 x2.75m. With this window we expect to obtain a relevant position in the market and create 16 new jobs.

Keywords: insulated window,energy saving,thermal performance,energy sustainability,nearly zero building
Services to enhance the innovation management capacity of SMEs in the macro-region 1 in Romania (InnoCap Transylvania)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Romania,Romania,Romania,Romania,Romania
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 100590.0
EU funding (EUR): 100590.0
Participants: 6
Project status: CLOSED

The objectives of this proposal are the following:Increase efficiency and effectiveness of innovation processes of local beneficiaries of SME instrument and SMEs with significant innovation activities and high potential for internationalisation;Facilitate SME’s access to consulting services for innovation management to address bottlenecks to creation of economic impact;Support innovative SME’s to raise the company’s profitability and competitiveness on international markets

Keywords: increase the efficiency and effectiveness of innovation processes of local beneficiaries
Women's Epistolary Networks, 1600-1700: Ireland and Beyond (WEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-28
End date: 2022-09-27
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Collaborating with Dr Ramona Wray (RW) of Queen’s University Belfast (QUB), an authority in editing and early modern women’s writing, the experienced researcher, Dr Ann-Maria Walsh (AMW), will undertake a fellowship – Women’s Epistolary Networks, 1600-1700: Ireland and Beyond (WEN) – to examine how one family of seventeenth-century women corresponded across European territories. At the centre of the fellowship are the 350+ manuscript letters produced between 1605 and 1691 by the Boyle women – the wife, daughters, daughters-in-law and grand-daughters of the 1st Earl of Cork. These extant and largely unexplored letters reflect the perspectives of three different generations and coincide with a hugely significant and tumultuous period in Irish, British and European history. Interweaving the disciplines of English, history, gender studies, Irish studies and European Studies, the fellowship will transform understandings of the relationship between literature, history and women’s writing. The fellowship will facilitate AMW’s mobility and produce a website, a major scholarly edition, an interdisciplinary conference and a co-edited volume of essays. Relevant training will run throughout the fellowship. A secondment will ground the fellowship’s archival scholarship in the Public Record Office of Northern Ireland (PRONI) and equip AMW with practical experience of archiving, curatorship and electronic cataloguing. This will allow AMW to develop the skills necessary to work effectively across European archives and embed the intersectoral skills increasingly required of an academic today. In addition, the mentorship of RW will provide an apprenticeship in editing which, alongside a previously published monograph, will establish AMW as a leading scholar of seventeenth century women’s history and literature. In this way, the fellowship will advance AMW in her scholarly achievements and richly enhance her career prospects.

Keywords: women,letters,seventeenth century,ireland,europe,epistolary,network
Fostering Critical Identities Through Social Media Archival Images (IMACTIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The aim of IMACTIS is to stimulate European citizens into using social network images in a way as to manage their identities in a critical manner. Digital media have profoundly changed the meaning of identity through two different shifts pertaining to social interaction. On the one hand, experience-based communication such as the acts of liking, following, and sharing, together with the diffusion of representations such as selfies, point of view shots, and live videos, have led to the dissemination of instinctive forms of identity expression. On the other hand, the profiling of people’s social and political circles (Facebook), entertainment tastes (Netflix), service or product needs (Amazon and AdSense), and even of their sexual partners (Grindr and Tinder), has led to the delegation of behavioural identity management to algorithms. The main hypothesis of IMACTIS is that in order to link experiential representations with algorithmic management in the current communication environment, a reflexive and conscious narrative identity based on one’s own visual archives is required. By approaching images as an everyday language, I will develop two axes of research built on a semio-rhetorical perspective: 1) I will study, by means of big data computer science methods, the heterogeneous and complex European visual cultures to be found on social media: the ethnic and physical variety of people and places, and the most used configurations and themes. 2) I will build another, more complex set of visual corpora, that of found footage videos belonging to the fiction, information, and ludic macro-genres. These corpora will serve as an experimental field: the narration strategies built upon the reuse of visual archives will be adapted to identity narrations on social networks. The resulting repertory of rhetorical strategies will aim to exploit the positive diversity embedded in European Union identity, as stated in the official motto “United in Diversity.”

Keywords: semiotics,rhetoric,social network,identity,images,archive
Ultra-adaptive holographic computational imaging for seeing through random scatter, fibers, and around corners (See-Beyond)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 1
Project status: SIGNED

Optical imaging systems play an instrumental role in our modern life, from smartphones and automotive cameras to microscopes that are critical for clinical diagnostics. However, the penetration depth of even the most advanced systems is still unbearably limited by the inherent random scattering of light in complex samples. Examples span many applicative fields, including scattering in tissues and fog, limiting microscopes and laser-based systems. For decades, the notion of correcting scattering seemed unfeasible since it requires control of billions of optical modes. This conception changed a decade ago with the paradigm-shifting revolution of wavefront-shaping, demonstrating that scattering can be physically corrected using spatial light modulators with a number of pixels orders-of-magnitude smaller than the number of scattered modes. Wavefront-shaping led to astonishing breakthroughs, including my own works, from focusing through visually-opaque barriers to imaging around corners. However, beyond laboratory demonstrations, there is a fundamental gap in applying these revolutionary notions in most practical imaging applications, as wavefront-shaping is based on a physical, inherently 2D, limited-speed correction to a volumetric dynamic scattering problem, and it relies on known ‘guide-stars’ at the target. I propose a radically different route to remove these fundamental barriers and unleash the full applicative potential of wavefront-shaping, by shifting the burden from the physical hardware to a digital, naturally-parallelizable computational process. My approach is based on computationally emulating the optimal 3D wavefront-correction, found using only a few unique rapid holographic measurements. My solution is enabled by our recent discovery of guide-star free wavefront-shaping, where the target themselves serve as guide-stars, and the great increase in computational power. Its impact spans across important domains, from endoscopy to non-line-of-sight imaging.

Keywords: optical wavefront shaping,light in complex media,scattering,optical microscopy,micro endoscopy
Molecular glues for perovskite materials (PerovSAMs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-02-25
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This project aims at optimizing the interface between halide perovskites and different semiconductors through the use of self-assembled monolayers (SAMs). Such interface engineering will be applied to perovskite solar cells where SAMs will play the role of “molecular glues” between the active perovskite layer and charge transport layers (n- and p-type metal oxides as well as organic semiconductors). Through the grafting and self-assembly of short bifunctional molecules, PerovSAMs will ensure a smooth and close contact at the interfaces, favouring charge transfer in the cell, thus minimizing losses and enhancing the power conversion efficiency (PCE). Furthermore, this versatile methodology will also be applied to perovskite nanocrystals (NCs). Surface functionalization of the NCs with SAMs will allow the formation of a perovskite shell with a different chemical composition creating core-shell quantum dots with superior photovoltaic properties, boosting the incipient field of perovskite NC-based solar cells.

Keywords: perovskites,self assembled monolayers,interfaces,optoelectronics,nanocrystals
Functional dissection of the head-direction circuit in mouse retrosplenial cortex. (RSCHD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

Head direction (HD) cells provide directional information during spatial navigation and thus act as an internal compass. The goal of this study is to understand how the HD circuit creates a lasting neural trace of transient directional changes. Cells selective for HD have been identified in several brain regions, including the retrosplenial cortex (RSC), and display persistent activity in response to transient vestibular turning cues. Although a well-established theoretical framework proposes an elegant circuitry for achieving this self-sustaining activity, biological evidence for such a circuit is lacking. Studies of HD circuitry have faced significant challenges due to the necessity of functional monitoring at large and small scales in vivo, and precise stimulus control. This study will take advantage of recent advances allowing the targeting of specific cells and their inputs for chronic two-photon imaging in the awake, head-fixed, and passively rotated mouse. Experiments will aim to (1) determine the spatial and temporal organization of HD-tuned responses in RSC, and (2) functionally characterize the presynaptic inputs of HD cells. This information will validate or reject a prominent theory of neural network organization, and provide unprecedented insight into a poorly understood but critical brain function.

Keywords: navigation,calcium imaging,neural coding