Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Holistic Approach to enhance the Recyclability of rare-earth permanent Magnets Obtained from aNY waste stream (HARMONY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Italy,Germany,Belgium,United Kingdom,Slovenia
Call: Recyclability and resource efficiency of Rare Earth based magnets (IA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 7082502.5
EU funding (EUR): 6372570.51
Participants: 21
Project status: SIGNED

HARMONY project aims at strengthening the independency and the competitiveness of European industry, enabling a resilience value chain of raw materials by developing and validating at pilot scale an innovative, green and safe closed-loop recycling process of Rare Earth Elements (REEs) from End-of-Life (EoL) NdFeB permanent magnets. The recycling loop encompasses the collection and dismantling of EoL NdFeB magnets and WEEE scrap, the recovery of REE metals through an indirect recycling process, the production of recycled NdFeB powder via three direct recycling methods, the manufacturing of magnets from the recycled powder, and the validation of the recycled magnets in end-user applications. Collection and recycling steps will be implemented in 8 pilot plans reaching a final TRL of 6-7. The combination of direct and indirect recycling technologies will allow dealing with any scrap containing NdFeB in any form (sintered or bonded magnets). The recycled NdFeB magnets will be used in the same applications as the magnets made from primary powder, since they will exhibit comparable properties. Additionally, they will be recyclable via the same routes. A Dissemination, Exploitation, and communication Master Plan (DECMP) will be developed to maximize the impact beyond the lifetime of HARMONY project. HARMONY will build upon existing standards during the development of the novel products, ensuring compatibility with market conditions and increasing transparency for prospective customers. The economic, environmental and social viability of these processes will be demonstrated via Life Cycle Assessment (LCA), Social Life Cycle Assessment (S-LCA) and Life-Cycle Cost Analysis (LCCA). Furthermore, social innovation including citizen dialogue, policy issues, standardization and ethics will be considered to overcome the non-technological barriers that make difficult to introduce these novel technologies at the short term in the market.

Keywords: weee,eol ndfeb magnets,pyrometallurgy,leaching,solvent extraction,electrowinning,melt spinning,gas atomization,compaction,sintering,compression molding,hip,hot deformation,injection molding
Philosophical Foundations of the Edge of the Universe (EDGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1994721.0
EU funding (EUR): 1994721.0
Participants: 2
Project status: SIGNED

The EDGE project is a philosophical study of the concept of an edge or boundary as it relates to the universe on the largest scale. But what does an edge refer to when the region is the entire universe? Despite widespread use of this boundary, there is little agreement about how to interpret it: some have called it “heuristic”; others “incoherent’; and still others a “law of nature”. There is no unified perspective on the general nature of boundary conditions in physics, and no agreed-upon conceptual foundation for how they apply to the entire universe. We propose an ambitious but credible programme to overcome this challenging problem. We begin with a classification of the properties, uses, and epistemology of boundaries as they are generally used in physics, from the separation of mind and world to the interaction of two coupled systems, and over a wide range of theories. We then turn to cases in which the boundary of the entire universe plays a substantial role in the frontiers of physics. These threads will form the basis for a general framework for understanding boundaries in physics, establishing shared features as well as the dimensions along which they differ. This will finally allow us to produce the first general analysis of what the edge of the universe means in physics: its ontology, its uses, and how we know about it. The pay-off of this project is a path-breaking new analysis in philosophy, which establishes a major new account of our universe at its farthest fringes. In physics, it stands to help clarify the pathway for those physicists actively developing the frontiers of science by using boundaries of this kind. More generally, it will establish a novel, accessible account of our place in the universe in comparison to the farthest reaches of our imagination. The ambition of the EDGE project is to produce such an account that is philosophically rigorous, scientifically sound, and still manages to capture a sense of wonder about the cosmos.

Keywords: philosophy of science,philosophy of physics,boundary conditions,cosmology
DiAMonD - DIscovering Active MicroOrgaNisms implicated in adverse Drug effects (DiAMonD)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Spain
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 2
Project status: TERMINATED

The microbiome plays relevant functions on human health and disease, including roles in the efficacy and security of drug treatments. Capecitabine is a pro-drug of 5-fluorouracil, which is an active metabolite that targets tumor cells. This treatment is used for diverse cancers, including colon tumors, and is commonly associated with diverse adverse reactions such as the hand-foot syndrome (HFS), a skin deterioration for which there has not been discovered its causal mechanism. Preliminary data suggest that some skin microbes interact with 5-flourouracil. Here, I aim to study the dynamics and features of the skin microbiome of patients treated with capecitabine. Using massive parallel sequencing methods, I will look for microbial taxa, genes and/or functions associated with the presence/absence of HFS adverse reaction. Based on those data, I will select appropriate conditions to isolate microbial taxa likely implicated in HFS and I will study their ability to metabolize capecitabine and 5-florouracil. Then, with those microbes showing this activity, I will analyze their genomes and transcriptomes in presence/absence of these drugs to select candidate genes involved in this drug metabolism. Afterwards, I will perform docking methods to decipher more precisely the likelihood of the encoded protein to interact with the drug. Finally, I will validate this data with the phenotypic study of knock-out mutants lacking selected genes likely implicated in the drug metabolism. This project will provide understanding related with the roles of the skin microbiome in the appearance or protection against a skin adverse drug reaction. This knowledge may be used for the advance of a precise and personalized medicine in which the individual microbiome can be considered. The proposed project will allow me to gain skills in novel methods of microbiome studies and in project management, and will extend my research network boosting my career towards a mature and independent stage.

Keywords: microbiome host microbe interactions microbial skin communities drugs metabolism
A sustainable small scale model for formulation absorption screening (SMARTA)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Sweden
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

In this project our aim is to validate a small scale absorption model for sustainable and animal-free screening of pharmaceutical formulations intended for oral use. The model will use small volumes and low quantities of drugs and excipients, contributing to the sustainable approach taken. The advanced model will enable companies to early on identify the best formulation which enable and increase absorption after oral intake. The model can replace animal models, directing the research to few proof-of-concept studies in vivo in higher preclinical species rather than making use of formulation screens in rodents and higher species. Hence, our technology is a game-changer in the drug development process and significantly contributing to the reduce and replace focus areas of the 3R principles. The company has a strong scientific foundation, and the key people of Enphasys AB have extensive network with leading pharma and biotech companies as well as scientific key opinion leaders. Currently the company has validated its business with regard to our services to customers making use of prime examples from big pharma. In this Women Tech EU project, our aims are to explore a new small scale innovation building on the knowledge acquired on the patented technology own by Enphasys AB. Here, we will analyse the market value, extend and validate our business plan including the new small scale innovation, analyse the IP landscape for the new innovation, and identify sustainable manufacturer(s), preferably located in Europe.

Keywords: drug development,animal free models,formulation design and optimization,improved absorption,oral medicines,3r
Bridging Academia and Industry for Sustainable Agri-Food Solutions (LETSGROW)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal,Bulgaria,Lithuania,Poland,Slovenia,Germany,Spain
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 2743076.25
EU funding (EUR): 2743076.25
Participants: 11
Project status: SIGNED

The European agri-food sector faces pressing global challenges, including food security, climate change, and sustainability. To address these, it must adopt a knowledge-driven strategy rooted in cutting-edge research and innovations towards a sustainable food system. Promoting interoperable R&I careers that bridge academic and non-academic (NA) sectors is essential for fostering new solutions. LETSGROW is based on three pillars: training, mobility of talents and policy development to support this effort. These aim to foster collaboration between sectors, ensuring knowledge and resource exchange that mutual benefits. This mutualistic approach can nurture a fertile environment for R&I talents. Training focuses on equipping R&I talents with the evolving competencies of both sectors. LETSGROW addresses current gaps by building up talents’ skills as well as the institutional competence to support talents and their careers, offering a set of 37 training activities. Mobilities play a critical role in preparing R&I talents to work across sectors. LETSGROW offers: quality-based talent selection, a mentoring system, a return plan to maximise impact, and mobilities coupled with training. The cross-sectoral exchanges will allow NA talents to gain practical, industry-related experience, while gaining insights from academic research. Mobilities are designed so R&I talents gain critical competencies while involved entities establish and promote future collaborations. Evidence-based and needs-based policy is essential to enable positive change, and lessons learned from both training and mobility activities will feed co-creation of policy recommendations to enhance R&I talents career interoperability and employability. LETSGROW’s combined impact of targeted training, cross-sector mobilities, and supportive policy development will promote competitiveness of the R&I talents and the consortium, which gathers 11 Partners (7 from 5 Widening countries), including 4 NA entities.

Keywords: career development interoperable careers,cross sector collaboration sustainability agri food sector
Documentation of intergenerational transmission in Zoroastrian women's silk weaving (DocZow)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

Zoroastrian women's silk weaving has all the characteristics of intangible cultural heritage; because it is both traditional, contemporary and alive at the same time, which has been continued through inter generational-transmission. For this reason, this project complements Iran's global registration under the title "Sericulture and traditional production of silk for weaving " by UNESCO in 2022. Chinese silk was imported to Iran through the Silk Road in the Sassanid era, and it led to the establishment of silk textile workshops to supply silk textiles inside and outside of Iran. The official religion during the Sassanid era was Zoroastrianism, but from the beginning of Arab Muslim rule until today, few Zoroastrians have remained. The non-alphabetic language of Zoroastrians is called Dari-Behdini and half of the speakers are Zoroastrian women, who played the role of bearers and preservers of intangible heritage, oral literature and traditions related to silk textiles from the Sassanid era to the contemporary period and localized the heritage of Chinese silk using the positive aspect of Cultural appropriateness and founded a new form of it. The silk textiles of Zoroastrian women are important from social, cultural and religious aspects: 1-The producers and consumers of silk textiles are only women and women have spread and taught it through inter generational-transmission until today. Women have not only been highly successful in retaining and transmitting traditional methods and practices, but also in adapting them in innovative ways with high levels of technical competency. 2-Although silk is a non-native product that came to Iran from another culture, Zoroastrian women turned silk textile products into their cultural capitals and used it as a symbol of cultural identity. 3-Although silk dyeing and using it is associated with obstacles based on the importance of purity in Zoroastrian religion, but until now, it is used as the only type of Traditional clothes.

Keywords: zoroastrian women s silk weaving,inter generational transmission,intangible cultural heritage,
Design of efficient catalytic nanomaterials as a pillar of a sustainable economy (ADVCATALNANOMAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-10-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 5
Project status: SIGNED

The ADVCATALNANOMAT project covers one important topic “the decarbonization of the energy sector” as the core for a sustainable economy. In this direction, the synthesis of methanol and higher alcohols from CO2 and renewable H2 is considered, aiming to increase process efficiency in order to accelerate the deployment of CO2 based technologies. To achieve this, the specific objectives of the project are: i) the design of new catalytic systems based on non-layered 2D metal oxides through topochemical transformation using ultrathin layer double hydroxides (LDH) precursors, ii) optimize the reaction conditions through kinetic studies, iii) establish a relationship between structure and activity to achieve a better understanding of the nature of the active site and its reaction mechanism, supported by mathematical models and theoretical studies, and iv) test and evaluate the performance of catalysts at semi-industrial scale, bridging the gap from the laboratory to a pilot plant. Innovative materials, with particular surface properties that relates to the coordination number of metal cations, defect sites, high surface area and high metal dispersion will be prepared targeting high alcohol selectivity (C1-C5) in the hydrogenation of CO2. In this direction, multifunctional catalysts containing Cu (for non-dissociative C-O bond activation), Ni (for dissociative C-O activation), and Co (for C-C coupling) will be explored. The success of this proposal lies in the interaction of several disciplines, including material science, the use of advanced spectroscopic characterization tools including Synchrotron Light Radiation tools, chemical engineering and theoretical simulation. All these will support the proposed research and provide the necessary knowledge for the design of new catalysts. It is a very ambitious project with significant scientific, social and environmental impact, contributing to strength the know-how in the field of catalyst design and CO2 valorization.

Keywords: co2 hydrogenation,synthesis of nanomaterials
Identification of bat antiviral innate immune effectors (batAVIRPro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Numerous recent disease outbreaks have been linked to zoonotic viruses originating from bats, including Marburg, Nipah, and the severe acute respiratory viruses like SARS-CoV-2. Countless virus-host encounters during bat evolution have shaped chiropteran immunity to balance defense and tolerance to viral infections, ultimately participating in bats current interplay with viruses and capacity as a viral reservoir. One of the first barriers against invading pathogens is the innate immunity, which notably includes antiviral factors that directly or indirectly inhibit the replication of invading viruses in the host cell. Recent research on bats showed the functional diversification of several antiviral effectors underscoring their pivotal role in bat immunity. However, because only a handful have been studied, my goal is to identify key and novel antiviral effectors within bat genomes, employing a bioinformatics-driven approach coupled with cellular and molecular virology techniques. First, I will perform genomic, transcriptomic and phylogenomic analyses to identify the genes expressed in immune pathways and under strong positive selection during bat evolution (denoting their in vivo importance). Second, I will characterize the most promising candidates, by genetic knockout and overexpression of variants in bat and human cell lines. Finally, the antiviral activity of the candidates will be tested against a broad spectrum of viruses: retroviruses, positive- and negative-strand RNA viruses. Taken together, the proposed project will not only identify novel antiviral factors in bats, which are also active in human cells, but will also shed light on the adaptive processes of chiropteran innate immunity, which occurred during bat evolution.

Keywords: bats,innate immunity,antiviral immunity,virus host coevolution,species barriers,comparative genomics
Next-Generation Front End Readout Electronics for Particle Physics Experiments (NexGenRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2026-08-31
Duration (months): 12.0
Total project cost (EUR): 101062.56
EU funding (EUR): 101062.56
Participants: 1
Project status: SIGNED

As outlined in the European Strategy for Particle Physics, the field is entering a pivotal era with major initiatives such as the completion of the LHC, the proposal for a "Higgs factory," and the development of next-generation hadron collider. This project responds to these advancements by focusing on the design and development of state-of-the-art readout electronics, specifically innovative Analog-to-Digital Converters (ADCs). These ADCs are critical for enhancing data acquisition systems in high-energy physics (HEP) experiments, impacting the precision and reliability of experimental data. By tackling the challenges of achieving high resolution, speed, compactness, and low power consumption, this project aims to advance detector technology and support the exploration of fundamental physics. Additionally, the proposed advancements will have broad applicability in nuclear physics, medical imaging, and other fields that utilize advanced particle detection technologies.

Keywords: detector readout,readout electronics