Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chemical interrogation of microtubule eraser enzymes (CHEMTUBIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1668750.0
EU funding (EUR): 1668750.0
Participants: 1
Project status: SIGNED

Erasers of protein post-translational modifications are ubiquitous regulatory enzymes that control cellular function and are targeted for the treatment of disease. One key example are erasers of histone acetylation, where inhibitors have reached the clinic as cancer chemotherapy. Currently, however, multiple other erasers lack tools of study to determine their relevance and generate clinical candidate molecules. One main reason for this limitation is that erasers display multivalent substrate recognition mechanisms that are difficult to replicate with standard assays in vitro and can jeopardise data translation. I have recently developed a solution to detect histone deacetylase activity in situ not on peptides, as it commonly done, but on semi-synthetic protein substrates and complexes, and still applicable to in vitro screening. My preliminary data supports that this methodology can be applied as a more general strategy, enabling studies and drug development on erasers currently inaccessible. Moreover, it holds great potential to localise eraser activity in living systems and generate maps of enzyme action on endogenous biological structures. CHEMTUBIO aims to generalise in situ eraser activity detection through application to the erasers of tubulin tail detyrosination. These enzymes generate gradients of detyrosination across the cytoskeleton lattice through mechanisms unknown and, even though inhibitors are attractive to treat cardiac and neuronal disorders, no probes are available for further investigation. Here, we will address these knowledge gaps and provide in situ sensors and chemical probes to advance the therapeutic application of detyrosinase inhibition. Furthermore, CHEMTUBIO will develop semi-synthesis methods to allow the study of microtubule lumen modifications. Erasers of luminal acetylation are attractive targets against neuromuscular disease and cancer, and we will provide key mechanistic knowledge to boost future therapeutic developments.

Keywords: post translational modification,fluorogenic assay,peptide medicinal chemistry,protein semi synthesis,tubulin
An open access knowledge and data repository to safeguard soils (SoilWise)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Belgium,Netherlands,Czechia,Serbia,Germany,Italy,France,Greece
Call: Building the mission's knowledge repository and advancing the European Soil Observatory (HORIZON-MISS-2022-SOIL-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 6305443.75
EU funding (EUR): 5999968.75
Participants: 15
Project status: SIGNED

More than ever, soil health is an issue, as recent assessments state that 60-70% of European soils can be considered unhealthy. The Soil Deal for Europe aims to have 75% of EU soils healthy or significantly improved by 2030. Reaching such an ambition requires, among others, access to reliable, harmonised existing and new data and knowledge collected at local, national and EU levels to allow informed decision-making at all scales to support the Soil Health Law and the EU Soil Strategy. SoilWise will provide an integrated and actionable access point to scattered and heterogeneous soil data and knowledge in Europe, making them FAIR (Findable, Accessible, Interoperable and Reusable) and improve trust, willingness, and ability to share and re-use soil data and knowledge. In three project development cycles, co-creation and co-validation by multi-stakeholder groups are the centre of project activities. SoilWise recognises existing workflows and repositories for specific user needs and aims to work with them to enhance their discoverability, approachability and interconnection. An open, modular, scalable and extensible knowledge and data repository building on existing and new technologies will be provided while respecting data ownership, access policies and privacy. AI- and ML- techniques will be employed to interlink scattered data and knowledge, automatise the processes, infer new knowledge and increase FAIRness. SoilWise applies infrastructure thinking instead of project thinking to design a repository for at least a decade to support EUSO evolvement accordingly. The SoilWise repository and community are designed to be a joint starting point and common ground for countries, the European Commission and other stakeholders to jointly guide soil and related spatial policy and informed decision-making towards the 2030 goals of the Green Deal, achieve healthy soils in 2050 and ensure broad uptake and implementation by land managers, policy, research and industry.
Sensorbees are ENhanced Self-ORganizing Bio-hybrids for Ecological and Environmental Surveillance (SENSORBEES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Czechia,Austria,Italy,Bulgaria,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2359068.75
EU funding (EUR): 2359068.75
Participants: 5
Project status: SIGNED

SENSORBEES aims at using honeybee colonies as a sensor network for tracking a set of important but undersampled ecological status variables 1) the level of pollination service in the surrounding region and 2) the level of diversity of blossoming plants. The pollination of plants is not only significant for human society in agriculture but it is also the trophic basis of the food webs that support all the other trophic layers of animals that are currently endangered in the 6th mass extinction that we are currently facing. We will equip a honeycomb that fits into a conventional beehive with a micro-robotic system that can reach every single cell on the comb. Thus, we will be able to inspect the content of each cell selectively and store its assessment into a database, containing the history of each single comb cell over years. The robot will photograph the brood in the cell at full-size from a short distance, allowing its size and health measurement. SENSORBEES will perform specific manipulations on these comb cells, for maximizing and ensuring pollination service to the environment, to favor and support plant diversity, and to defend itself against detrimental developments. Moreover, we will equip the hive with a smart pollen trap capable of selective collection and visual analysis of the pollen brought into the hive by the bees. The pollen influx, along with the data collected by the robotic agents in the hive will provide information about the health of the colony as well as on the diversity of plants within the foraging area of the bees, i.e. 5-10 km around the hive, thus sample areas of 78-314 sq km. Health estimates on the colony level can be made by looking for anomalies in brood growth and breeding success and by comparing the data streams from the hive entrance, local weather data and brood dynamics. Data fusion will be applied to several colonies to e.g. locate potential problematic feeding sites.

Keywords: environmental monitoring systems,cyber physical systems,robotic sensors
An innovative and versatile Additive Manufacturing Process: Dynamic Molding (Dynamic Molding (DM))

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2025-10-31
Duration (months): 30.0
Total project cost (EUR): 4159028.16
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

3D printing technology is marred by various challenges including but not limited to longer production time, restricted design, production wastage and also lack of materials compatible with 3D printing device. 3Deus Dynamics is designed to accelerate innovative technology disrupting the 3D printing process to push the limits of manufacturing by combining the advantages of injection molding and 3D. Our Dynamic Molding technology is a new radical concept of Additive Manufacturing (AM) in which the building environment is composed of a controlled granular phase (powder), behaving like a dynamic molding system in which manufacturing materials (inks) are dispensed. Our technology has successfully produced silicones solutions for medical industry, and personal medical equipment’s. The fund from EIC will be utilized to finalize the development for Silicone, extrapolate to other materials and accelerate the commercial development.

Keywords: injection molding,3d printing,additive manufacturing process,dynamic molding
SecQdevOps- Trustworthy Quantum DevOps for Secure Software and Hardware Quantum Engineering (SecQdevOps)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Germany,Greece,Ireland,Cyprus,Bulgaria,Portugal,Spain,Switzerland
Call: Approaches and tools for security in software and hardware development and assessment (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 7711776.21
EU funding (EUR): 5962342.35
Participants: 18
Project status: SIGNED

The emergence of quantum computing as a transformative technology has made secure hardware and software development an imperative. Quantum computing’s potential depends on robust, secure infrastructures that support quantum algorithms while addressing vulnerabilities. However, rapid development often prioritizes functionality and speed over security, creating gaps in comprehensive quantum-specific security practices, as highlighted by agencies like ENISA and NIST. Such gaps pose risks due to quantum algorithms' complex attack surfaces, which traditional security solutions cannot adequately address. This challenge is especially pertinent in the European Union (EU), where it is essential to integrate security engineering in both software and hardware development, ensuring compliance with EU standards and providing auditable quantum systems. The SecQdevOps project tackles these critical issues by creating a secure, continuous DevOps pipeline explicitly designed for quantum software and hardware development. Leveraging quantum high-level programming languages like Qiskit and Eclipse QRISP, alongside secure hardware-aware compilers, SecQdevOps provides automated security assessments and real-time vulnerability detection to build efficient, trustworthy quantum applications resilient to cyber threats. A unique aspect of SecQdevOps is the Internet of Quantum Things (IoQT), a distributed platform that connects emulated quantum devices across multiple secure nodes for collaborative testing and development, offering a secure “playground” for next-generation developers.
Attenuation of ethological traumatic memories (EthoFearless)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1497500.0
EU funding (EUR): 1497500.0
Participants: 2
Project status: SIGNED

Traumatic experiences generate among the strongest memories that can result in trauma-related disorders. Despite the high prevalence of these disorders, effective treatment options are scarce, calling for a deterministic understanding of the neuronal mechanisms underlying traumatic memory attenuation. For this, rodent studies classically use fear extinction paradigms where aversive experiences are modeled with the exposure to an electrical foot shock. However, the simple nature of this stimulus does not mirror the complexity of traumatic events in humans which is likely to be processed by equally complex networks. Here, I propose to investigate for the first time the neural circuits underlying the extinction of traumatic memories induced by exposure to naturalistic threats, namely, predators and aggressive conspecifics. First, we will compile a comprehensive atlas of brain activity underlying extinction of these ethological traumas and generate network organization models, which will be causally probed by pathway-specific chemogenetic manipulations. Second, we will characterize the functional input-output connectome of ethological extinction centers using a combination of viral tracing, neuronal activity and optogenetically assisted circuit mapping. This set of data will, third, provide the substrate for the study of the neurophysiological and molecular mechanisms underlying efficient extinction of ethological traumas, which will be analyzed by pathway-specific in-vivo Ca2+ imaging, closed-loop optogenetics, ex-vivo electrophysiology and RNA sequencing. Lastly, we will investigate whether impairments at the level of these newly identified networks underlie extinction deficits at the basis of trauma-related disorders. Together, these results will pave the way for the identification of novel therapeutical targets for trauma-related disorders and shed light on how the brain can flexibly update complex memories.

Keywords: fear extinction,ptsd,neuroethology,learning and memory
Hidden Legacies How discontinued International Organizations have shaped European governance since the 1910s (InechO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2497395.0
EU funding (EUR): 2497395.0
Participants: 1
Project status: SIGNED

What happens after international organizations (IOs) cease to exist? While IOs’ ends are occasionally discussed in political science and legal studies, we know very little about the legacy of IOs, and hence the subsequent role and impact of people, ideas, practices and objects (including buildings and budg-ets) that once filled such organizations with life and meaning. InechO hypothesizes that for a full un-derstanding of international history and questions of political governance more broadly, it is indispen-sable to consider the legacy and impact of liquidated IOs. New beginnings frequently echo the work of earlier IOs, even if existing interpretations and narratives ignore or downplay such links. Using largely neglected public and private sources as well as interviews, InechO will break new ground for interna-tional and European history by focusing on the “afterlives” of European International Organizations since the 1910s. It highlights five empirical case-studies representing the whole spectrum of possible options. Informed by and contributing to an interdisciplinary state of the art, InechO builds on an in-novative set of concepts and methods to address these issues. InechO will thus establish a new con-ceptual framework that will help research to rethink the nature of international cooperation and interna-tionalism. Its approach and its findings are also highly relevant for the analysis of other world regions and their international history and for audiences beyond academia.

Keywords: european history,international history
High energy Intelligence (HeI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal,Spain,France,Italy,Canada,United States,Netherlands,Brazil,Switzerland
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 671600.0
EU funding (EUR): 671600.0
Participants: 11
Project status: SIGNED

Understanding the basic building blocks of Nature has led to the Standard Model, a non abelian quantum field theory with particles and glue that explains within a single framework the forces between the basic constituents of matter. However, the description of strongly coupled emergent phenomena has remained a hard problem to solve, especially with traditional methods. In recent years, new techniques have challenged this difficulty by showing that an optimized knowledge of symmetries and consistency conditions actually leads to unprecedented quantitative results. Both the conformal and the amplitude bootstrap have proven this idea to be successful. A first objective of the High-energy Intelligence -HeI- project is to extend the horizon of applicability of bootstrap methods by finding better constraints and more rigorous predictions, eg. as path towards quantum chromodynamics (QCD) study the conformal window of QCD-like theories, study integrable and supersymmetric theories, and for quantum gravity, study those theories that have a gravitational dual within string theory. A second objective of the HeI project, specific and original, is to push the boundaries of our understanding of QCD physics, by obtaining the most refined partonic distribution functions of quarks and gluons in nuclear matter. A third objective, timely and novel in the proposed approach, is to combine an Artificial Intelligence and Machine Learning training with cutting-edge research in theoretical physics, having in mind neural networks designs that can be trained on partial data sets, and at the same time, solve the non-perturbative constraint equations coming from theory. The HeI project, for the first time, brings together many scientists working on related aspects of high-energy physics but with different areas of specializations, to make a collaborative scientific breakthrough, through secondments to leading research institutes in Brazil, Canada, Switzerland, and the Jefferson Laboratories.

Keywords: quantum field theories effective field theories of qcd factorization and rg parton distributions cft s matrix integrable field theories supersymmetric theories
Tribo-Reactor for fluorine circularity by urban mining (TriFluorium)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria,Spain,Germany,Belgium
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 2913913.75
EU funding (EUR): 2913913.75
Participants: 5
Project status: SIGNED

TriFluorium largely expands current circular economy capabilities for highly stable organofluoride waste (PFAS, including fluoropolymers) and provides safe, sustainable and efficient regeneration of fluorine into safe, stable inorganic fluorides as industrial resource, such as fluorspar. Fluoropolymers are indispensable for many critical (e.g., semiconductors) and green (e.g, hydrogen production, fuel cells, EVs) applications and their disposal options are very limited. Needed fluorspar resource is listed as EU’s critical raw material and is acquired outside of the EU with recycling rate at 1% due to the lack of proper technologies. TriFluorium wants to achieve proof of the tribolysis recycling principle for organofluorides (TRL 3) irrespective of particular chemical structure, molecular weight, or liquid/solid form under properly designed controllable tribocontact site, which promotes chemical reactions initiated by mechanical stimuli. Tribolysis shall within one processing step generate local dense-energy spots to initiate decomposition of very stable organofluorides, including the perfluorinated ones, and to activate safe reactants, such as alkaline earth metal (Group II) salts or oxides to efficiently convert organofluorides into safe, stable inorganic products (mineralization). TriFluorium will also develop a dedicated Tribo-Reactor for laboratory scale validation of tribolysis F-recycling (TRL 4) for process scaling and enhancement of tribolysis technology development towards industrial application. The locally initiated reactions with benign reactants have inherently safe operational and energy-efficiency features. Supporting toxicological and LCA assessments will be carried out to comprehensively evaluate tribolysis recycling process and Tribo-Reactor performance from all relevant perspectives. The foundation of tribolysis recycling for organofluorides answers urgent technological needs and contributes to current environmental, economic, and social goals.

Keywords: tribochemistry,mechanochemistry,tribolysis,tribo reactor,pfas,fluoropolymers,fluorine recycling,urban mining,circular economy,sustainability,critical raw material crm