Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
3D-printed boNes and Tendon-inspired Hierarchical Electrospun Scaffolds strategies to enhance the Enthesis regeneration via Stem cells (3NTHESES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

3NTHESES will bring together innovative additive manufacturing (AM) and electrospinning (ES) biofabrication strategies, to produce a new generation of multi-layer hierarchical multi-material scaffolds (MLHMMS) able to faithfully mimic the multiscale morphology and the mechanical performances of the enthesis tissue. MLHMMS will be designed to drive the stem cells fate. Starting from the morphological study of an animal model, several imaging techniques will be used to acquire and measure all the morphological features of the tendon, the fibrocartilage and the bone tissue. The bone images will be used to produce bone-inspired AM mineralized scaffolds that will be directly printed on ES hierarchical nanofibrous tendon-inspired partially mineralized scaffolds, reproducing the whole enthesis. The mechanical performances of the MLHMMS will be compared with the natural tissue using mechanical tests matched with imaging strain analysis. The optimized MLHMMS, will be seeded with stem cells in comparative static and dynamic cultures in bioreactor following their proliferation, differentiation in tenocyte, fibrochondrocytes, osteocytes and the production of different biological markers, using imaging and biological characterizations. Finally, the cellularized constructs will be mechanically compared with the natural tissue using biomechanical tests. The applicant (Dr. Alberto Sensini) is a research fellow in biofabrication and biomechanics. He will apply the tendon-inspired ES hierarchical scaffold, developed during his Ph.D., and his imaging/biomechanical skills to enhance the biomimicry of these constructs. Moreover, thanks to the supervision, mentoring and training activities provided by the host organization (Maastricht University) on bone AM, stem cells cultures and biological characterizations, he will complete his interdisciplinary biofabrication expert profile.

Keywords: enthesis regeneration additive manufacturing electrospinning stem cells differentiation bioreactors biological characterizations high resolution x ray tomography biomechanical tests
Tracing Visual Computations from the Retina to Behavior (Eye to Action)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1871465.0
EU funding (EUR): 1871465.0
Participants: 1
Project status: SIGNED

Every second, millions of bits of information enter our eyes. How does the brain identify task-relevant information from this gigantic input stream? This key challenge of the visual system is tackled by substantially processing the sensory input for behavioral relevance. Already in the retina, the front-end of the visual system, neuronal circuits extract multiple features from the environment and form up to 40 channels to the brain. So far, however, one of the basic principles underlying vision, namely how the brain processes these multiple channels from the eye, remains fundamentally unclear. In this proposal, I will focus on the superior colliculus, an evolutionary conserved retino-recipient brain area critically involved in visuomotor transformations, and solve the following problem: How do neuronal circuits in mouse superior colliculus integrate retinal signals to drive behavior? I will implement an interdisciplinary approach that combines population imaging of neuronal activity in behaving mice with optogenetic manipulations, deep neural network modeling, and quantitative behavioral analysis. By modeling a defined brain area all the way from the retinal input to its role in behavior in an ecological setting, I will mechanistically dissect the behavioral relevance of retinal circuits. My work will uncover general principles of how diverse retinal channels are represented in downstream targets, identify elemental convergence rules of feedforward retinal signals in postsynaptic neurons, and causally link retinal function to distinct behaviors. If successful, my proposal will reveal fundamental neuronal and computational mechanisms used by the visual system to convert a complex visual input into action. My approach can be adapted to other sensory modalities, guiding the design of innovative experiments and analyses. The identified mechanisms of efficient information processing will also contribute to the development of robust neuro-inspired artificial intelligence.

Keywords: visual system retina visually guided behavior superior colliculus functional two photon imaging retinal ganglion cells deep neural network models
Augmented Social Play (ASP): smartphone-enabled group psychotherapeutic interventions that boost adolescent mental health by supporting real-world connection and sense of belonging (ASP-belong)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Austria,United Kingdom,Czechia,Portugal,Ireland,Norway
Call: Boosting mental health in Europe in times of change (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2186730.0
EU funding (EUR): 2186730.0
Participants: 11
Project status: SIGNED

In our fast-changing society, poor mental health and social isolation are increasing among young people, exacerbated by the pandemic. Belonging – feeling connected to and accepted by others through supportive interpersonal relationships – is key to boosting mental health and overcoming loneliness. There is a lack of evidence-based interventions addressing belonging, particularly in schools, which remains a central space for adolescent socialisation. Digital technologies, while disrupting the social landscape, offer enormous potential for adolescent health management. This project develops Augmented Social Play (ASP), a pioneering digital mental health intervention format whose feasibility has been established through proof-of-concept prototype. ASP uses smartphones to deliver real-world group experiences that combine immersive storytelling, augmented reality, collaborative face-to-face gameplay and evidence-based psychotherapeutic methodologies to boost individuals’ mental health while fostering a greater sense of belonging within the group. Collaborating across academia, industry, education, health and the arts, and working with young people, we will co-develop ASP #1, a full-scale, multi-session intervention. We will implement this intervention in schools in Portugal, Czechia, and the UK, using strategies informed by policy review, and evaluate its efficacy, cost-effectiveness and implementation in order to present an evidence base to stakeholders including policy-makers, practitioners and media, stimulating wide uptake. We will further evolve ASP by collaborating with vulnerable adolescents to ensure we meet the widest spectrum of needs; by prototyping additional ASP interventions aimed at different populations and threats to mental health; and by creating comprehensive ethical guidelines. Our long-term goal is wide-scale adoption of ASP, making multiple smartphone-delivered group mental health interventions freely accessible to diverse populations and settings.

Keywords: belonging adolescents augmented reality creative arts social connectedness co development smartphone school education social disadvantage social psychology digital intervention
Project Regulus: Reducing EU health and economic burden of chronic inflammatory diseases with a selective and effective JAK1 inhibitor (Regulus)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Addressing the rising socioeconomic challenges of chronic inflammatory and immune-mediated disorders in the EU through more targeted pharmacological approaches is crucial to reach higher efficiency, safety and affordability. Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by esophageal inflammation and dysfunction, also known as allergic esophagitis or "eczema" of the esophagus, with difficulties and anxiety around swollowing. EoE is diagnosed in 1 in 2,000 individuals, with an increasing incidence. The EoE market is growing with a double-digit CAGR, reaching $5-10B by 2038. The current reliance on non-selective PPIs and corticosteroids, or the expensive alternative of biologics (Dupixent), highlights the urgent need for targeted and more selective treatments grounded in the principles of precision medicine and a thorough understanding of diseases. A transition to more selective small molecule drugs not only improves drug efficacy and safety, but also carries economic promise by curbing overall healthcare costs. Aqilion’s clinical program, Regulus, involves the development of AQ280, a highly selective JAK1 inhibitor, that has a broader cytokine inhibiton profile than Dupixent. Besides the improved efficacy and safety profile, the Regulus project involves a fast-dissolving small molecule formulation as innovation for patient convenience as EoE patients have problems swallowing. As AQ280 will be of lower cost in pricing and production, it will provide a strong health-economy case to the EU and could become first-line treatment for EoE. We have recently completed a successful phase 1 clinical trial and are continuing our formulation development and producing GMP material, as well as preparing IND application and supplementary toxicology studies. To continue with phase 2 clinical trial and bolster investor confidence, we seek EIC blended finance support.

Keywords: eosinophilic esophagitis
IENAI SPACE; Space mobility solutions for the next generation of small satellites. (SCORREYERO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: EU Prize for Women Innovators
Action type: Recognition Prize
Countries involved: Spain
Call: Rising Innovators Category (HORIZON-EIC-EIT-2023-WomenInnovatorsPrize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

In the past decade, the space industry has seen remarkable growth, driven by the emergence of "Small Satellites" weighing less than 1kg. These small satellites gained popularity due to their lower costs, technological miniaturization, and the adoption of distributed satellite architectures. Currently, they have very limited access to efficient on-board propulsion solutions, which is vital for collision avoidance, space traffic management, and compliance with space debris mitigation guidelines. In response to these challenges, IENAI SPACE was founded in 2019 and introduced the "Space Mobility Store," featuring ATHENA, a customizable electric propulsion system, complemented by AI-powered space mobility SaaS. The company's innovative "in-space mobility" philosophy centers on co-engineering propulsion solutions tailored to specific satellite platforms. This approach enhances flexibility, optimizes maneuvers, and promotes the seamless integration of propulsion systems into spacecraft. ATHENA-π, a pico-satellite version of the thruster, successfully launched in 2022, marking a significant milestone for the company. Sara Correyero, the company's COO, has played a pivotal role in driving technical development, overseeing daily operations, and securing funding. Additionally, she actively promotes STEM education, particularly for women, aiming to inspire future generations of scientists and engineers. Correyero's contributions to the space industry have garnered numerous accolades, including the "Young Engineer of the Year" award, recognition in a periodic table highlighting Spanish women in STEAM fields, and the "Inspiring Women Leader in the Digital Era" prize. Her work epitomizes entrepreneurship and STEM advocacy within Spain's space sector, ensuring a brighter future for space exploration and technology.

Keywords: propulsion spacetech mobility electric rocket science
Bio2Skin, the first clinically skin-preserving biomaterial replacing silicones/acrylate as medical skin adhesives (Bio2Skin)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 3560815.71
EU funding (EUR): 2492571.0
Participants: 1
Project status: SIGNED

External medical devices, such as ostomy pouches, wound dressings or wearable electronic devices, require the use of medical adhesives for their attachment to the skin. However, prolonged use of current medical adhesives is associated with serious adverse skin reactions, MARSI (Medical Adhesives-Related Skin Injuries). This underreported issue is prevalent in 25% of wound care cases and is associated with enormous health care and economic burdens. BH4U aims to address this challenge with Bio2Skin. A patented revolutionary glueless medical adhesive that uses the natural features of the skin to establish a water-based link and overcomes the disadvantages of acrylic/silicone adhesives. Bio2Skin is a bio-based, cost-effective, recyclable solution offering gentle, safe adhesion and kind removal. The product, with a potential of >250M EUR by 2030, will be sold under license to medical adhesive manufacturers and external medical devices manufacturers.

Keywords: medical skin adhesives,medical adhesives,skin injuries,chronic wounds,polymers,biomaterials
Real-time wave and ship motion prediction to enhance safety and operability of critical offshore vessel operations (WavePredictor)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

The workability of various types of offshore operations – such as crew transfer from CTV (crew transfer vessels) or SOV (service operation vessels) to offshore platforms or wind turbines - is highly affected by waves and wave induced motions. Sea waves behave in an irregular and unpredictable way; occasionally exceeding certain operational limits, but we do not know when and where such waves occur. Thus, predicting severe wave events is crucial. Nowadays the operability of offshore operations is assessed from a statistical point of view. This involves determining limiting wave conditions for an offshore operation to take place based on statistics and applying huge safety margins in operational limits, leading to excessive downtime: wave conditions are considered unworkable because of events that very rarely occur. Next Ocean aims to radically transform how wave analysis and forecasting works, by introducing WavePredictor, the first in-site, deterministic, wave and ship motion prediction technology. Next Ocean’s approach focuses on considering the sea surface elevation from a deterministic point of view. Advanced software able to provide real-time information on when and where high waves or high motion response occurs instead of taking their probability into account. Next Ocean has developed an onboard real-time decision support system that enables to: • Predict Wave & Ship Motions: Predict quiescent periods and extreme motion events up to 3.5 minutes ahead; onboard and in real-time. • Decision Support: Provide the crew, the information they need to perfectly time the most critical offshore operations by getting a warning when upcoming ship motions are likely to cross operational limits. • Less Risk: As a result, it reduces operational risk up to 10x compared to operating without WavePredictor. • More Uptime: Operate safely in seas up to 20% above the conventional operational limits (i.e. based on significant wave height – Hs), without reducing operational

Keywords: wave propagation,predictive algorithms,offshore operations,real time prediction of approaching waves,ship motion prediction,maritime engineering,offshore wind,wave energy conversion
TranscULturality and social innovation in frontier AReas of pre-Roman Italy (TULAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2026-03-31
Duration (months): 33.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Fundamental transitions in societies can be caused by several factors; amongst those, human connectivity can have a pivotal role. The TULAR project focuses on human mobility and transculturality (the coexistence of diverse culture) in archaeological sites, investigating their impact on cultural and political dynamics in ancient populations of pre-Roman Italy. The project will combine traditional archaeology (the analysis of funerary ritual and material culture) and cutting-edge scientific tools (multi-isotope, aDNA and data analysis) to provide a new understanding and novel instruments for interpreting the dynamic of interaction, formation, and development of emerging complex society in the Mediterranean. The Etruscans of pre-Roman Italy are optimally suited to exploring this phenomenon, having woven webs of networks across the peninsula and experienced considerable socio-political changes (e.g., the passage from villages to cities) in their formative phases. TULAR (Etruscan for border) examines principal proto-Etruscan frontier sites, where fluctuation in transculturality is commonplace. Despite all being initially part of the same network, those sites experience diverse cultural and political outcomes, suggesting variation in network development and offering the optimal dataset for the study. TULAR will revise the traditional narrative of the Etruscan civilisation, so important for contacts in temperate and Mediterranean Europe, providing a compelling reworking of our understanding of the European Iron Age. Meanwhile, it will offer a methodological blueprint for studying transculturality and socio-political development globally, framing new directions in research on mobility and its impact on ancient societies.

Keywords: mediterranean archaeology iron age italy etruscans human mobility multi isotope analysis 87sr 86sr,18o,34s,13c,15n cross disciplinary approach
Radiation Effects in Data-carrying Nanostructures (NEO Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 480425.0
EU funding (EUR): 480425.0
Participants: 2
Project status: SIGNED

The present hop-on project focuses on the testing and improvement of the radiation resistance of the novel data-carrying nanostructures developed in the NEO project. NEO nanostructures are aimed for high data write density with cell size in the nm range and for long-term data storage on thousands of years' timescales. Damage induced by natural radiation exposure will be an important contributor to the data loss on the aimed bit densities and storage timescales, particularly considering that the nanostructures will be made of DNA, a molecule with known susceptibility to radiation damage. The stability of the nanostructures will be evaluated to test the hypotheses posed in the original NEO proposal and the measures to improve long-term data preservation will be implemented to improve the readiness level of the developed technology. The main contribution of the new partner is the expertise in studies of radiation damage to DNA and DNA nanostructures, which is lacking in the NEO consortium. For several years the researchers at HIPC have developed a complex methodology to evaluate radiation damage to DNA nanostructures and DNA extensions of the nanostructures, such as the ones that will be used for data writing in the NEO project and will provide the methodology to the consortium within the present project. HIPC will profit from a completely new collaboration with top groups in the field of DNA data storage, which is an emerging field of nanotechnology in Europe. The visibility of the group's expertise and infrastructure will be improved making a promise for higher involvement of the group in future collaborative projects in this research domain. The foundation of this field of nanotechnology in Czechia also improves its research alignment with European Research Area objectives conforming with the goals of the Widening scheme program.

Keywords: dna storage,dna origami,dna radiation damage,long term data storage