Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Outcomes of Patients’ Evidence With Novel, Do-It-Yourself Artificial Pancreas Technology (OPEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Australia,Germany,Ireland,Switzerland,Belgium,United States,United Kingdom,Denmark,United Kingdom,Denmark
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-02-01
End date: 2023-04-30
Duration (months): 51.0
Total project cost (EUR): 1021200.0
EU funding (EUR): 1021200.0
Participants: 11
Project status: CLOSED

Type 1 diabetes is a rare but highly challenging chronic condition which often leads to lowered life expectancy and greatly diminished quality of life even amongst those patients who are the most diligent and proactive in the practice of disease self-management. In recent years, there has been a growing movement of ‘patient innovators’ leading the development of self-built or ‘do-it-yourself’ artificial pancreas systems (DIYAPS), which help to automate day-to-day decision making needed for successful self-management. There is prima facie evidence to suggest that such systems can lead to improvements in glucose outcomes that far exceed those offered by the most state-of-the-art commercially available solutions. The aim of this RISE project is to tap into the expertise and knowledge shared by these communities by bringing together an intersectoral and interdisciplinary research team consisting of patient innovators, academic researchers, healthcare professionals (HCPs) and NGOs to establish an empirical evidence base surrounding the impact of DIYAPS. The exciting programme of research includes training and networking for participating staff designed to encourage inter-disciplinary thinking and broaden career horizons, while the dissemination and public outreach activities will ensure that project findings reach key stakeholders, such as policymakers, HCPs and industry, both within Europe and beyond. The key outcomes of this project will include a new model of knowledge co-creation and an evidence-base surrounding the potential scale-up of DIYAPS solutions that will have profound implications for those living with chronic conditions, their families, as well as healthcare systems and European society as a whole.

Keywords: connected health,diabetes,patient public involvement ppi,health inequalities,mixed methods,realist evaluation
Fundamentals and Applications in Magnetism of Extraterrestrial Samples (FAMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Understanding the “conditions for planet formation” is the first item listed on the European Space Agency’s decadal plan for space sciences. This ambitious task is particularly challenging in that asteroid and planet formation in the protoplanetary disk was influenced by a plurality of factors that can no longer be observed. For example, magnetic fields generated by the disk or the first accreted bodies likely contributed to shaping our solar system, but are today extinct. Most experimental data inform us on the dynamics and evolution of the early solar system are collected on meteorites. Meteorites are remnant pieces of the first accreted planetary bodies; their composition and properties hold a unique record of the conditions under which these objects formed. In particular, the magnetization of meteorites provides unique information on the intensity of magnetic fields present in the early solar system. However, reconciling the magnetizations measured in the laboratory with the intensities of ancient fields is one of the most challenging tasks in paleomagnetism. With this proposal, I aim at calibrating the relationship between magnetization and field intensity for three major magnetic minerals found in meteorites. I will subsequently use these calibrated data to build a more accurate record of the protoplanetary disk’s magnetic field. The two-way transfer of knowledge between the host (CEREGE, France) and myself is essential to the realization of this project. I will leverage and share my knowledge of synchrotron-based magnetic microscopy with the host team, while benefitting from their longstanding expertise in paleomagnetism, petrography and meteoritics. After a five-year PhD in the US, I will be returning to France with the ambition to apply for permanent academic positions over the course of the fellowship, and to durably contribute to the influence of European research.

Keywords: paleomagnetism,meteorite,magnetic microscopy,solar nebula,core dynamo,solar system formation
Linking chemistry and physics in the planet-forming zones of disks (MOLDISK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2282440.0
EU funding (EUR): 2282440.0
Participants: 1
Project status: SIGNED

The heavy elements (C, O, N) in exoplanetary atmospheres result from accretion of gas and impacts of icy pebbles and planetesimals in disks around young stars. The gas and dust, in turn, originate from the collapsing cloud that formed the star plus disk, with icy grains growing, settling and drifting in radially to the planet-forming zones. The inner disk (0.1-10 au) is a key region in planet formation, yet its physical and chemical structure is still poorly constrained observationally. The next years offer huge observational improvements at infrared wavelengths, which is the primary regime to study inner disks. Most notably, JWST offers unique diagnostics of gas and ice at unprecedented sensitivity and sharpness. The applicant has been heavily involved in planning and building of JWST-MIRI for the past 25 years, and co-leads GTO programs on protostars and protoplanetary disks. This proposal requests funding for 2 postdocs and 3 PhD students to carry out an interdisciplinary program that analyses MIRI data as soon as they arrive by mid-2022, and makes crucial connections with ALMA and VLT(I) data, state-of-the-art disk models developed by the applicant’s team, and laboratory experiments on ices. The specific goals are to (i) determine the chemical inventory of gas in inner disks, and measure C/O/N/H ratios in exoplanet birth environments; (ii) relate differences in chemical composition between disks to locations of dust traps, icy pebble sublimation at snowlines, and presence of cavities; (iii) compare the chemical properties of young embedded disks with mature disks, and establish the role of accretion shocks may have on their composition; (iv) determine the abundances of ice species, including the presence of more complex icy molecules, as well as their chemistry from envelopes to disks; and (v) find indirect evidence for the presence of young unseen (massive) planets. MOLDISK will train a next generation of mid-IR scientists, important for ELT and SPICA.

Keywords: astrochemistry
Global cellular connectivity for small and medium-sized IoT device makers (IoT4ALL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Estonia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mobi Solutions (MOBI) is a provider of value-adding telecommunication services to enterprises operating world-wide. The company develops a cellular connectivity platform 1oT™ that makes it affordable for every emerging small and medium-sized IoT (Internet of Things) device maker to globally order, set up and manage operator switchable or embedded SIMs (Subscriber Identification Module) via one simple Application Programming Interface (API) platform. The connectivity platform will disrupt current business practices in the IoT connectivity market by implementing a number of technological and business model innovations. The platform will be interoperable with all current and emerging SIM types and will handle seamless switching between multiple carriers. The platform aims at providing the best cellular data rates for each country or a region worldwide. The first prototype of the 1oT™ platform (TRL6) with limited functionality has been made available for pilot customers since August 2016. The expected outcome of the feasibility study will be a confirmation of the technological and economic viability of extending the current prototype to cover a full range of SIM options. Different off-the-shelf hardware components will be tested for assessing technological feasibility. In-depth market study will be carried out to validate user needs. These studies feed into an updated business plan of MOBI for successful exploitation of a planned innovation project. According to the current estimations, Total Addressable Market will be above €10 billion in 2020 as the global number of IoT devices with cellular connectivity will be above 700 million then. MOBI hopes to surpass €10 million in revenue by 2020 and €30 million by 2022. Very positive feedback from the first customers and contacted would-be customers indicates that the service could gain market traction very fast.

Keywords: internet of things,cellular connectivity platform,application programming interface
Feasibility study to evaluate a novel prostate cancer diagnostic (ProstaPalp)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Palpation Diagnostics is developing the ProstaPalp technology, a novel in vivo medical device, which can measure the physical characteristics of the prostate during a routine digital rectal examination. The technology has been developed over the last 17 years in collaboration between clinicians at the Edinburgh Western General Hospital and engineers at Heriot-Watt University. The technology addresses the unmet need of a diagnostic that can be used in the active monitoring and triaging of patients, with suspected prostate cancer. Every year more than 45 million men worldwide are screened for prostate cancer and 8 million men referred for a biopsy – around 1.3m biopsies in the EU. Around 75% of these biopsies are unnecessary. The biopsy procedure is painful and associated with a number of secondary complications, such as erectile dysfunction and incontinence. Our device provides a triage test allowing patients without significant disease to be removed from the clinical care pathway. It can also be used to actively monitor those patients remaining. The commercial potential is significant, with an addressable global market of over £1bn. Palpation Diagnostics will conduct a feasibility study to detail the commercialisation route for the technology. It will further validate the clinical need, regulatory environment, quantify key markets, detail products development costs and route to market. The feasibility will complement an on-going clinical trial in Edinburgh and lead into an application for Phase 2 Horizon funding. This will then be used for further clinical validation and product development. Our device can triage patient from the clinical pathway and provides a low cost approach for active monitoring. The Prostapalp helps addresses the global and European challenge of spiralling healthcare costs, which is largely due to an aging population (EU Ageing Report: Economic and Budgetary Projections, 2012).

Keywords: prostate cancer
'Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis (ProstOmics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Norway
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-03-31
Duration (months): 74.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Overtreatment in prostate cancer (PCa) is a burden for health care economy and for quality of life. Correct diagnosis of early stage PCa is challenging given the limitations of the currently available clinical tools and the biological understanding of PCa. In this inter-disciplinary project, I propose an innovative approach enabling several cutting-edge ‘omics’ technologies (spatial metabolomics, genomics, transcriptomics) as well as histopathology to be performed on the same tissue sample. My goal is to reveal the molecular mechanisms of novel, but also promising metabolite biomarkers (citrate, polyamines, succinate and zinc) and their connection to recurrence, tissue heterogeneity and immune responses in complex human tissues. Such markers can personalize PCa diagnosis, open up new treatment strategies and fundamentally change the view of how to analyze tissue samples in the future. Furthermore, I want to demonstrate that citrate and polyamines are reliable prognostic markers that can be analyzed both in tissue and in patients in vivo by MR spectroscopic imaging. This work is made possible by the availability of high-quality fresh frozen tissue biobanks of prostatectomy biopsies with 5-10 years of follow-up data (N=1000)/slices (N=1000) and targeted in vivo snap-shot biopsies from clinical MR guided procedures (N=100). Among other techniques, I will implement high speed MALDI imaging (RapifleX MALDI TissueTyper) to the multi-omics protocol to study the spatial distribution and provide high resolution metabolic maps for each cell type, and which can be matched to both histopathology and MR Imaging. Multi-disciplinary platforms on large cohorts are needed to explore the clinical potential of the suggested molecular mechanisms. I expect that this ambitious proposal will address the diagnostic challenges of PCa and will further inspire the clinic and scientific community to follow the multi-omics approach within diagnosis and cancer research.

Keywords: diagnosis,prognosis,prostate cancer,biomarkers,maldi imaging,magnetic resonance spectroscopy,citrate,polyamines,zinc,tissue heterogeneity,inflammation,immune responses
SKYTUNEUP: THE ULTIMATE PLATFORM TO OPTIMIZE AND SECURE THE USE OF PUBLIC CLOUD TO ORGANIZATIONS (SKYTUNEUP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2018-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Skytuneup is the first solution for smart management of cloud resources that has been proven to guarantee: - Up to 90% cost reduction, by managing the dynamic pricing of Spot instances (the most beneficial -but still underexploited- purchasing business model in cloud computing, which base costs on the demand), predicting future prices and selecting the most adequate at any given moment and also automating cloud operations, further reducing costs with the optimal scheduler and lowering the manual effort in cloud management task by starting, stopping and resizing the clients’ instances automatically when they are needed. - 100% system availability and minimum complexity: it deploys client’s cloud instances between multiple availability zones and distributes capacity between multiple instances types, so jobs won’t be interrupted. - +100% security increase, via dedicated algorithms to control protection levels and cloud resources, scheduled backups and snapshots of cloud services to define retention plans for automatic deletion of expired backups. Skytuneup manages and optimizes multi-cloud deployments, enabling enterprises to fully realize their cloud potential. Its uniqueness is based on a radically new approach relying on two main elements: novel intelligent algorithm engines capable to manage the dynamic pricing of Spot instances (at the moment only one company in Israel is exploiting such instances for their business) and a new business strategy: opposite to competitors, Skytuneup aims to obtain benefits from the savings of their customers, thus aligning with their business strategy. Enimbos expects that Syktuneup’s total revenue will reach over 55M€ and 500 employees by 2023. Enimbos will address a 3-stage internationalization strategy targeting the UK, Northern Europe and the US, which will position the company as an international reference in cloud optimization and will contribute towards the company’s growth.

Keywords: cloud computing,cloud optimization,spot instances,cloud market,price prediction engine
Adaptive and maladaptive endothelial cell dynamics during blood flow-driven vascular patterning (ADAPT2FLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-01-28
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

The formation of a functional patterned (adaptation) vascular network is essential for development, tissue growth, and organ physiology. Several human vascular disorders arise from the mis-patterning (maladaptation) of blood vessels, such as arteriovenous malformations, aneurysms, and diabetic retinopathy. Blood flow is recognized as the main inducer for vascular patterning, yet very little is known about the molecular mechanisms that vascular patterning. C. Franco and others recently highlighted that endothelial cells polarize and migrate against the blood flow direction. Yet, how this behavior contributes to the overall process of vascular patterning is completely unknown. This project aims to study the dynamics of endothelial cells in vascular patterning during development, homeostasis, and disease. Taking advantage of a unique new transgenic mouse line reporting endothelial cell polarity in vivo, I will investigate endothelial cell behavior in vivo, including endothelial cell polarity, collective and individual migration and cell rearrangements, using 2-photon microscopy. I will extend this analysis to understand the involvement of endothelial flow-dependent polarity in formation and development of arteriovenous malformations. Finally, I will perform an in vivo functional screen to identify novel regulators of endothelial flow-dependent polarity, using a combination of automated image analysis and hemodynamics modelling. This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in adaptive and maladaptive endothelial cell dynamics during blood flow-driven vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.

Keywords: angiogenesis,blood flow,cell polarity and migration,vascular patterning
Lyapunov exponents and rigidity phenomena in dynamical systems and mathematical physics (LYP-RIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-07
End date: 2021-08-06
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This fellowship builds on the success of the applicant’s PhD thesis, where he made breakthroughs in the study of the frequency of hyperbolic behavior, i.e. simplicity and non-vanishing of Lyapunov exponents in dynamical systems. The concept of Lyapunov exponent were introduced in the work of A. M. Lyapunov on the stability of the solutions of differential equations in 1892. The concept plays a central role in most areas of modern theory of dynamical systems, mathematical physics, differential geometry, among others. The problem of the frequency of hyperbolic behavior, in various settings, has been extensively investigated by many leading mathematicians. The main goal of this project is to study the Lyapunov exponents in the most general setting, and investigate its role in rigidity phenomena in dynamical systems. This project specifically aims at applying techniques from modern theories of complex analysis and complex geometry (field in which the supervisor is a world leading expert) to the study of Lyapunov exponents (the applicant’s area of expertise). This proposal has four main objectives: 1 - Explain the frequency of the simplicity of Lyapunov spectrum for symplectic cocycles; 2 - Establish positivity of Lyapunov exponents for the general structure group; 3 - Understand the frequency of hyperbolic behavior for infinite dimensional "symplectic" cocycles; 4 - Employ new techniques from Lyapunov exponents to the rigidity conjectures, in particular, Katok-Spatzier types conjectures.

Keywords: dynamical systems,lyapunov exponents,spectral theory,rigidity phenomena,schr dinger operators