Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INDUCTION HARDENING WITH INTEGRATED ATOMIZED SPRAY QUENCHING FOR HIGH QUALITY MATERIALS (HARDATOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our Company, TERMOMACCHINE, is specialized in design, manufacturing and sale of electromagnetic induction systems and installations (from medium to high frequency, from 15 to 600kW generators). With more than 35 years of experience, we have developed a range of innovative machines that can operate in various industrial fields, such as automotive, tube & pipe, railways or oil & gas. To sustainably grow in the manufacturing world where the competition with the low-cost countries is particularly strong, our philosophy has always been to set the bar with high quality and reliable products and superior post sale services. Moreover, with the export representing 90% of our business (€5.8M in 2012), we pride ourselves in being very reactive to the markets, always targeting new niche markets with turnkey solutions to consolidate our leadership while ensuring our development. In this regard, based on feedbacks of our customers from the automotive, machine, metalworking and manufacturing (e.g. TRW, GKN, FPT, Profiltubi S.p.A) about problems of geometric and metallurgical distortions present in their hardened components and complex parts, we have acted and have been working on HARDAtom: technology integrating a new quenching system, using atomized spray, within our induction hardening systems. This innovative solution for high quality hardened metals (deformation and residual stress delta < 5%), being price-competitive (about €200,000 for the whole induction hardening + quenching solution, while market prices average around €150,000 to €500,000 for only hardening) and environmental friendly (no use of polymer quenchants), will enable our company to consolidate new sustainable niche markets in the tube & pipe, automotive and machinery sectors, thus subsequently increasing our sales by 25% within 5 years.

Keywords: hardening,induction,quenching,atomized spray,metal
Design and Manufacture of Scaled up 50 kg capacity Plasma Melt Overflow (PMO) system for the commercial production of titanium and iron-chrome-aluminium alloy fibres. (PlasMelt)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A previously funded FP7 project MEMLAB has opened new business opportunity for the mass scale titanium fibre application to a novel lead acid battery market. 75.2 million lead acid batteries are used in Europe. Capturing 4% of this market by titanium fibre substrate technology will require 3 million of these batteries and 301 tonnes of titanium fibre production yearly. Currently titanium fibre is used only for very specific applications due to the complexity of the production process and high price. In order to satisfy the new market opportunity, a melting and casting process capable of producing fibres directly from a melt using scrap as a source is required to reduce costs of the fibres. We have developed a 200g prototype PMO system through a new process by integrating plasma arc melting to our unique melt over flow process. This is capable to produce titanium fibre from titanium scrap with specific shape required for the battery. Our system is 41 times cheaper and will create several new titanium fibre market applications. In order to be commercially viable, we would need to upgrade our PMO system from 200g to 50kg capacity, which would be able to produce 550 tonnes of titanium fibres per year. The PMO process can be applied to produce other metallic fibres e.g. FeCrAl alloy fibres to be used as the advanced catalyst coating substrate material for self-regenerative Diesel Particulate Filters (DPFs). FeCrAl alloy substrate is a good candidate for the next generation of DPFs due to its advantages of reduced cost and superior performance in filtration efficiency (more than 90%) and passive regeneration through soot burn-off. This has a huge business potential and is timely, especially as Euro VII legislation will require zero particulate emissions from diesel vehicles in cities by 2020. The project will help Fibretech to become a leader in the metallic fibre industry.

Keywords: plasma melt over flow system,titanium fibre,plasma torch,metallic fibre,lead acid battery,diesel particulate filter
TRapped ENSembles of Circular RYdBErg atoms for quantum simulation (TRENSCRYBE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 2240000.0
EU funding (EUR): 2240000.0
Participants: 3
Project status: SIGNED

TRENSCRYBE proposes a groundbreaking concept for a quantum simulator (QS) of spin systems. QSs aim at an in-depth understanding of many-body physics, important for fundamental issues (quantum transport, phase transitions), but also for the development of engineered materials. A QS transcribes the system of interest into another with the same dynamics but with a fully controlled Hamitlonian parameter set. It provides a complete access to all the systems observables and allows the exploration of regimes, in which numerical simulations are difficult or impossible due to the huge size of the Hilbert space. QSs of spin systems are the focus of an intense activity, e.g. with trapped ions, superconducting devices, atoms in optical lattices or low-angular-momentum Rydberg atoms. I propose with TRENSCRYBE a disruptive QS using trapped circular Rydberg atoms. Their microwave spontaneous emission can be inhibited, extending their lifetime in the minute range. In contrast with ordinary Rydberg states, they can be trapped in optical lattices, allowing one to take full benefit from such exceptional lifetimes. I propose an innovative preparation method of ultra-cold defect-free chains with a few tens of atoms. The QS realizes a Nearest-Neighbor XXZ spin-1/2 Hamiltonian in a transverse field, the spin states being coded on circular levels. Its parameters are fully tunable by adjusting a static electric field and a microwave dressing applied on the atoms. I will first benchmark this QS by adiabatic evolutions through the phase diagram of a 1-D chain in a regime where numerical results are available. I will explore quenches through quantum phase transitions and the generation of defects in a regime where numerical or theoretical predictions are difficult. I will realize a first step towards 2-D arrays with spin ladders and explore their topological phases. The realization of TRENSCRYBE will open a whole realm of new possibilities for quantum simulation of spin systems.

Keywords: quantum simulator,ultracold rydberg atoms,spin chain
BotsAndUs - First Assistant Robot for Retail, Hospitality, Aiports and Real Estate Buildings (BOTSANDUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2021-06-30
Duration (months): 28.0
Total project cost (EUR): 2649687.5
EU funding (EUR): 1854781.25
Participants: 1
Project status: CLOSED

Bad customer service leads to losses of over £37Bn for companies in the UK and $87Bn in the US alone each year. The companies from retail, hospitality, airports and real estate-buildings, which are our four key business verticals, are facing issues of understaffing, lack of insights and in-store inconsistencies, leading to a high degree of customer unsatisfaction. Therefore, there is an urgent need of introducing new technologies to boost customer service quality and sales. BotsAndUs created Bo, a robot easy-to-use, able to autonomously approach and engage in conversation, reacting to emotions, with the best Human-Robot-Interaction features. This innovative breakthrough technology combines social sciences, human-centred design and cutting-edge engineering. The robot is unique, complex and superior to all other product on the market, leading to a cut of 70% of losses caused by bad customer service, yet at an affordable price. Bo was tested and presented to various international events and companies and there is currently a demand of over 1,000 units to be deployed immediately. Bo has been proven to work in prototype trials (TRL6), raising high interest from customers, receiving orders of about €300K. Our potential clients are from Europe, Middle East and USA. The technology is highly scalable and can be deployed easily within existing distribution systems. During Phase 2, BotsAndUs will develop a fully working demonstrator (WP2), install a production infrastructure (WP3), carry out full-scale trials with pilot partners (WP4) and prepare the business plan and commercialization strategy (WP5). BotsAndUs targets the global serviceable market currently worth about €5Bn annually, which thanks to technological advances is likely to explode. The goal is to reach a turnover of over €144Mil. in 5 years after Phase 2 implementation, creating multiple jobs within EU, while leading to a wealth of follow-on applications in the service robotics and autonomous technology industry.

Keywords: assistant robot,retail,hospitality and airport customer service,human robot interaction
Regenerative treatment of complete Traumatic Spinal Cord injury with a surgical implantation of a biodegradable device with FGF1 and nerve grafts (SC0806)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Estonia,Norway,Finland,Sweden,Denmark,Denmark
Call: Clinical research on regenerative medicine (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 13981411.0
EU funding (EUR): 6397077.0
Participants: 8
Project status: CLOSED

Today there is no regenerative therapy available for treatment of complete spinal cord injuries (SCI). BioArctic Neuroscience develops a novel treatment of complete SCI. The method is based on the regeneration of functional nerves in the injured spinal cord. Nerve grafts are transplanted into the injured spinal cord, by using a biodegradable device, loaded with a growth factor and nerve grafts (these three components are abbreviated SC0806). Efficacy and safety of the treatment has been demonstrated in an in vivo model of SCI. The therapy has been designated Orphan Drug status in Europe and in USA. Ethical approval to commence into clinical trial in Sweden was recently granted. The proposed project is the first clinical trial of the treatment of complete spinal cord injury. Following surgery at the Karolinska University Hospital, patients will receive rehabilitation in their home countries, with state of the art robotics equipment, at clinics in Denmark, Finland and Sweden. This clinical study will be the first in-human trial with this new treatment concept. Several interim analyses are included in the study design to secure the safety of the patients. This is a single dose study in up to 3 sequences (A, B and C) in 27 subjects with complete traumatic SCI. In the first sequence (A), 6 subjects will be randomized to a surgical procedure where SC0806 will be implanted at the spinal cord, and receive robotics assisted walking training for 18 months, and 3 subjects will be randomized to specific walking training only. For safety reasons, the first three subjects will be operated on and implanted with at least 1 month in between. If efficacy is demonstrated, control subjects from (A) and (B) and (C) will later be given the opportunity to receive treatment with SC0806.The proposed project spans a period of 42 months and will start nov 2014 with screening, inclusion and treatment of patients in Sweden.

Keywords: spinal cord injury,growth factor,rehabilitation,physiotherapy,robotic training,device,nerve grafts,surgery
Carrier for Cure: tailored combination drug delivery solutions for oncology (CfC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-11-01
End date: 2019-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chemotherapy, often given in conjunction with other therapies is infamous for its off target associated side effects. Recent studies have shown that drugs combinations can act synergistically at certain ratios and are more effective and less toxic than single drug therapies. Despite promising in vitro results, combination drug therapy for Oncology has not been successfully translated to the clinic due to lack of efficient delivery systems that can maintain the desired synergistic drug concentrations in the body as each drug has a different pharmacokinetics and toxicity profile. The objective of this project is to develop a universal platform for simultaneous delivery of multiple drugs to specific cells in vivo using a protein cage that was developed in our laboratory for encapsulation of diverse cargoes.

Keywords: protein cage,protein design,drug delivery,protein therapeutics,cancer therapy,combination chemotherapy
Nano-OptoMechanical Systems for Biological Sensors (NOMBIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2019-01-14
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The emergence of antibiotic resistance is one of the major challenges in microbiology and medicine today. Early identification of the pathogens causing an infection and the rapid identification of antibiotic resistance is critical to provide the most effective drugs to the patient and to avoid costly and inefficient treatments that can potentially lead to the development of further resistances. This project proposes application of nano-optomechanical disk resonators to face this challenge. We expect to achieve ultra-sensitive and ultrafast gene-based pathogen detection with subzeptogram (10-21g) mass resolution, beating current techniques. The development of arrays of 100s of microdrum devices per chip will weigh complementary DNA strands to those immobilized on the microdrum surface, so tens of different pathogens in a sample can be identified, along with antibiotic resistances, which are also marked by mutations. The devices will be challenged with a proof-of-principle application to identify sepsis-causing pathogens from blood samples and their resistance to the most commonly used antibiotics. The proposed devices provide a large binding area to reduce the analysis time while preserving extreme sensitivity, down to a few biomolecules (DNA strands). We will be able to screen for tens of different pathogens per chip, with sensitivity good enough to target early infection stages from a standard blood extraction. This multidisciplinary and intersectorial project promotes the collaboration of well-recognized academic research groups expert in the optomechanics field and in the development of novel biosensing tools, a clinical laboratory and an industrial partner, pursuing to generate greater economic and social impact; as well as a highly effective training program for the benefit of the researcher.

Keywords: nanomechanical biosensors,optomechanics,nanomechanics,nanomechanical mass sensing,biosensors,microbiology
Artificial endosymbiosis (ARTISYM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Living organisms have acquired new functionalities by uptake and integration of species to create symbiotic life-forms. This process of endosymbiosis has intrigued scientists over the years, albeit mostly from an evolution biology perspective. With the advance of chemical and synthetic biology, our ability to create molecular-life-like systems has increased tremendously, which enables us to build cell and organelle-like structures. However, these advances have not been taken to a level to study comprehensively if endosymbiosis can be applied to non-living systems or to integrate living with non-living matter. The aim of the research described in the ARTISYM proposal is to establish the field of artificial endosymbiosis. Two lines of research will be followed. First, we will incorporate artificial organelles in living cells to design hybrid cells with acquired functionality. This investigation is scientifically of great interest, as it will show us how to introduce novel compartmentalized pathways into living organisms. It also serves an important societal goal, as with these compartments dysfunctional cellular processes can be corrected. We will follow both a transient and a permanent approach. With the transient route biodegradable nanoreactors are introduced to supply living cells temporarily with novel function. Functionality is permanently introduced using genetic engineering to express protein-based nanoreactors in living cells, or via organelle transplantation of healthy mitochondria in diseased living cells. Secondly I aim to create artificial cells with the ability to perform endosymbiosis; the uptake and presence of artificial organelles in synthetic vesicles allows them to dynamically respond to their environment. Responses that are envisaged are shape changes, motility, and growth and division. Furthermore, the incorporation of natural organelles in liposomes provides biocatalytic cascades with the necessary cofactors to function in an artificial cell

Keywords: polymersomes,nanoreactors,biomimetic,artificial organelles
Styles of Objectivity: Agency, Alignment, and Automation in Image-Guided Surgery (IMAGUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Advanced imaging technologies are currently transforming operating rooms into sophisticated augmented reality studios that explore recent developments in computer visualization, navigation applications, and robotic systems. The new imaging methods promise to increase precision and improve health outcomes. However, as medical diagnosis and therapy grow more dependent on images, the status and roles of these images become increasingly controversial. Image-guided applications reshape clinical practices, impact medical decisions, and transform the relationship between physician and patient. The objective of the project is to develop a new framework that accounts for the active role of images in surgical contexts, providing a systematic basis for handling the impact of these images and assessing their controversial aspects. The project pursues its goal through a collaborative and interdisciplinary effort that involves medical practitioners. It articulates the visual knowledge of medical practitioners by undertaking in-depth operational analyses of three image-guided technologies in current use: the 3D Slicer software application, the da Vinci surgical system, and the CyberKnife robotic radiosurgery system. The analyses introduce the notion of styles of objectivity, which accounts for the key features of these applications, including agency, alignment, and automation, while acknowledging that images have a certain agency and that there is an inner connection between aesthetic and epistemic factors. A second objective of the project is to contribute to conceptual and methodological innovation through a two-way transfer of visual literacies across medicine and humanities/social science domains, by operationalising the visual knowledge of surgical practitioners so that it can be fed into visual/media/science studies, and vice versa. This includes developing concepts for new ways of teaching the visual knowledge of medicine.

Keywords: visual studies,scientific images,science studies,medical imaging,image theory,visualisation,image guided interventions,philosophy of technology,medical humanities,relational ontology