Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural analysis of Rad51 paralogues involved in recombinational DNA repair (SARPBAXZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Homologous recombination (HR) is a major mechanism for repairing DNA double-strand breaks (DSBs). A DSB converts one normal chromosome into two pathological chromosomes, making it the severest form of DNA damage. Accordingly, defects in HR lead to genome instability, a potent driver of tumorigenesis. Although Rad51 is the central enzyme involved in HR, several auxiliary factors promote HR by stimulating Rad51. Rad51 paralogs comprise one family of evolutionarily conserved auxiliary factor. Unlike other auxiliary factors, Rad51 paralogs are notorious for their biochemical intractability, a trait that has greatly hindered progress in understanding their function, which in turn has precluded a more complete understanding of HR as a whole. This proposal aims to uncover the molecular mechanisms underlying Rad51 potentiation by Rad51 paralogs. To achieve this, we will employ an interdisciplinary approach combining structural biology, biophysics, biochemistry, and genetics. This proposal is particularly well-placed to deliver novel insights because the historical obstacle in the analysis of Rad51 paralogs—the native purification of functional protein of sufficient yield and quantity—has already been overcome by the Researcher. Furthermore, the Supervisor has extensive expertise in cryo-electron microscopy, which is now a viable approach to visualise the finer structural features of proteins that have been recalcitrant to classical techniques such as X-ray crystallography. Thus, by uniting the experiences of the Researcher and Supervisor, this fellowship has the potential to answer long-standing and significant questions in the field of HR. In addition to maintaining genome stability, HR plays critical roles in gametogenesis, chromosomal biology, and evolution. If awarded, this proposal therefore has the potential to impact several disciplines within the life sciences, and this is especially true given the interdisciplinary nature of the proposed research.

Keywords: rad51,reca,homologous recombination,genetic recombination,genome stability
The Politicisation of Economic Inequality: The Impact of Welfare Regimes, Elites’ Discourse and Media Frames on Citizens’ Perceptions, Justice Evaluations and Political Behaviour (POLINEQUAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1846875.0
EU funding (EUR): 1835625.0
Participants: 3
Project status: SIGNED

POLINEQUAL aims to investigate the causes and mechanisms that motivate citizens to respond to economic inequality. Conceptually, it is based on the assumptions that 1) perceptions of economic inequality are biased as they are mediated by justice evaluations and, thus, do not mirror objective levels of economic inequality, 2) perceptions of economic inequality are informed by facts, ideological cues, media representations or personal heuristics, 3) perceptions and evaluations are malleable to the extent that economic inequality is being politicized and becomes politically salient, and 4) politically salient perceptions and evaluations of economic inequality evoke emotional, attitudinal and behavioural responses. In my conceptualization, perceptions of inequality – and justice evaluations that instil them - originate from social norms that are deeply rooted in the ‘moral economies’ of welfare regimes and are malleable as a function of individual exposure to and receptivity of facts, ideological cues, representations and heuristics of economic inequality. POLINEQUAL pursues two paths. First, it investigates the nature of interrelationship between media representations, ideological cues and individual perceptions and evaluations of economic inequality and to what extent the latter are conditioned by collectively shared distributive justice norms. Second, it investigates the impact of politically salient individual perceptions and evaluations of inequality on emotions and political behavior. Its aim is to develop a theoretical framework which explains the causes and mechanisms of individual perceptions of income inequality being contingent on national institutional arrangements, ideological cues, media frames and personal heuristics and destabilizing democracies. The research design is based on a mixed-methods approach, organized in different stages and combining data derived from focus groups, discourse and content analysis, an online survey and an experimental study

Keywords: perceptions of inequality,justice evaluations,politicization,discourse,framing
Physiognomics as Philosophy: Reconceiving an Early Modern Science (PHYSIOGNOMONICA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-15
End date: 2023-10-14
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

My project aims to uncover the hitherto unrecognised centrality of physiognomics within early modern philosophy. Physiognomics is the theory, stemming from Aristotle and other ancient sources, that body and soul are connected in such a way that it is possible to gain access to the soul by learning to read bodily signs. Building on fresh interest in medieval physiognomy, the project focuses on the richest yet least-studied period for the development of the discipline: from the late 15th century, when physiognomic texts started to circulate in print, to the early 17th century, when Cartesian dualism reconceived the body-mind relationship. I will define the corpus of philosophical physiognomic literature, with special attention to Venice and Paris, two fulcrums of the revival, where the majority of my archival research will take place. The project’s objectives reflect the intrinsic interdisciplinarity of physiognomics in the period, investigating its practitioners’ approaches to: 1) the interrelation between science and magic; 2) the differentiation between humans and animals; and 3) the conceptual distinction between mind and body. Topical issues of gender and race in physiognomic theories will be addressed. The outputs will include a monograph, an edition of a primary text, and an online, open-access anthology of sources. This ambitious dissemination plan is enabled by Ca’ Foscari’s programme Marie Curie+1, together with my advanced research skills and publication record. At Ca’ Foscari and during my secondment at the Centre Koyré in Paris I will expand my areas of competence, especially in the history of science and in iconography. I will improve my French, a crucial language for my field. I will develop my palaeographical skills to produce a critical edition that will help to restore physiognomics to the intellectual map of early modernity. The project will thus greatly enhance the independence I need to secure my main career goal, a permanent academic post.

Keywords: early modern philosophy,physiognomics,science and magic,human animal differentiation,mind body relation,aristotle
Child prodigies: on giftedness and child celebrities in modern France (ChildPro)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Although there is no scholarly agreement on how to define “giftedness”, there is a consensus on why it is important: understanding giftedness, and especially, gifted children, means understanding human potential and development. Conceptions of giftedness affect education and parenting, and can create unrealistic expectations in adults and children. Child prodigies manifest an extreme form of giftedness. Research on giftedness is chiefly developed within psychology, and remains quite ahistorical. Meanwhile, historical research on prodigies focused on case studies, failing to account for today’s interest in gifted children. This project aims to go beyond these two approaches. It will explore how the history of child prodigies can help to explain the current fascination with giftedness. To do so, it will examine child prodigies in cultural and scientific settings (such as the theatre and the laboratory) in 19th and early 20th century France, mainly Paris. The project will address child prodigies as a cultural phenomenon that: a) influenced the western scientific interest in giftedness, and b) built a long-lasting entertainment culture around gifted children. The study will build upon past and current psychological research on giftedness, and contribute to fields such as the history of science, and childhood and celebrity studies. With my postdoctoral experience in an ERC project, and with a promising track record, I am prepared to move a step further. The MSCA will help me improve my skills in teaching and project management. In addition, I will be able to provide a historical background to a socially sensitive and timely topic. Overall, it will solidify my career, preparing me to apply for funding and academic positions to reach independence.

Keywords: history of psychology,child prodigies,giftedness,celebrity studies,history of childhood,childhood studies
Leap-to-Lead platform for expanding Drug Discovery beyond its current limits (L2L)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Health and wellbeing are among the basic and most important needs of humanity. Medicines have a major impact on the quality of life and are essential for treating various diseases. Despite the numerous achievements of the pharmaceutical industry, there are still diseases without effective treatment. Pharmaceutical industry is continuously searching for new compounds that can become drug candidates against such diseases. Development of one new drug can take about 15 years, cost up to 2-5 billion USD and includes several steps of research and development. The first step of the process is called drug discovery. Our company, BioBlocks is a collaborative medicinal chemistry research organization focused on drug discovery from initial lead discovery to development candidates, serving the needs of our clients: pharmaceutical and biotech companies. Answering to our identified clients’ need, using our experiences, we have developed and patented the Leap-to-Lead™ (L2L) concept, with the aim to expand Drug Discovery beyond its current limits. L2L consists of two major components that work in concert a Comprehensive Fragment Library (CFL), a proprietary collection of available fragments, and Syntheverse™, >500 Billion compound database. The next phase of platform development will expand its scope towards meeting its full potential: making it routine to identify viable new chemical matter for biological pathways that do not have a traditional target. We aim to speed up adding novel physical scaffolds to the CFL, for which we need to improve our internal chemical technology tools, and increase our resources for the project. Thus, we need to get external funding, such as investment and/or grant, e.g. SME Instrument Phase 2. We intend to make a convincing, detailed business plan that will increase our chances for obtaining such subsidy. The objective of this Phase 1 project is to prepare a feasibility study for these activities.

Keywords: medicinal chemistry,early stage drug discovery,lead generation
Galileo/GNSS-based Autonomous Mobile Mapping System (GAMMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Switzerland,Finland,France,Portugal
Call: EGNSS applications fostering societal resilience and protecting the environment (H2020-SPACE-EGNSS-2020, 2020)
Start date: 2021-07-01
End date: 2023-12-31
Duration (months): 30.0
Total project cost (EUR): 1929285.28
EU funding (EUR): 1383762.0
Participants: 8
Project status: SIGNED

In GAMMS we will develop an autonomous terrestrial mobile mapping system; i.e. a mobile mapping system (MMS) robot for geodata acquisition and an AI-based highly automated mapping software. In contrast to today’s manned MMS whose cost is dominated by 2- to 3-people crews, we envision fleets of low-cost, autonomous, electrically-powered land vehicles, carrying mobile mapping systems (MMS) and collecting geodata in a massive, continuous way. Although we will develop generalpurpose geodata acquisition and processing techniques, in GAMMS we focus on the rapidly growing market of the High Definition (HD) maps for the autonomous vehicles (AVs), a.k.a. self-driving cars. Because of the enormous task of mapping the world roads for AVs we will develop highly automated software to produce HD maps from the MMS remote sensing data. Because of the safety requirements of AVs, we will also develop map certification methods and quasi real-time, online techniques to continuously update the HD maps. The building blocks of GAMMS are: an electrically-powered AV, a MMS, a GNSS/Galileo receiver, multi-sensor trajectory determination software, multispectral laser scanners, vehicle dynamic models, automated mapping software and mission risk analysis methods. A keystone of GAMMS –which encompasses the extension of the Galileo receiver and the development of ultra-safe, ubiquitous navigation methods at the 5 cm error level– is the use of Galileo features (e.g. E5 AltBOC signal) and new services: navigation message authentication (NMA), high-accuracy serive (HAS) and signal authentication. Galileo and our trajectory determination methods enable the GAMMS concept. Our market value proposition is the production of high-accuracy high-reliable maps at a fraction of today’s cost. In a first fielding of the AMMS technology we will focus on the skyrocketing market of HD maps and, for this particular application, our value proposition includes the quasi real-time, continuous online

Keywords: autonomous vehicles,e5 altboc,galileo,gnss,high accuracy service,hd maps,navigation,navigation message authentication,trajectory determination,mobile mapping systems,vehicle,dynamic models
Development of an innovative gene therapy platform to cure rare hereditary muscle disorders (MYOCURE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Belgium,France,France,United Kingdom
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5998937.5
EU funding (EUR): 5998937.5
Participants: 9
Project status: CLOSED

The objective of MYOCURE is to develop an innovative gene therapy platform to cure rare hereditary muscle disorders, specifically focusing on myotubular myopathy (MTM) and glycogen storage disorder (GSD) type II. These are attractive diseases for gene therapy since they compromise a diverse family of rare genetic diseases typically caused by single gene defects that often provoke significant morbidity and mortality due to skeletal muscle, cardiac and/or diaphragm dysfunction. There are no effective cures and current treatment is suboptimal. MYOCURE focuses specifically on overcoming the key bottlenecks that hamper muscle-directed gene therapy by (i) boosting gene transfer using muscle-specific adeno-associated viral vectors (AAV) generated de novo by directed molecular evolution (ii) increasing expression by using robust computationally designed muscle-specific promoters that are 400-fold more efficient than the state of the art, allowing the use of lower and thus safer therapeutic vector doses (iii) minimize undesirable immune reactions against the vector, gene-modified muscle cells and therapeutic proteins. The efficacy and safety of this advanced therapy medical product (ATMP) will be validated in preclinical MTM and GSD II animal models. A scalable manufacturing process will be developed for subsequent toxicology studies and an orphan drug designation will be applied for. MYOCURE will consolidate a roadmap towards clinical development and economic valorisation and maximize dissemination to the relevant stakeholders. The outcome of MYOCURE will constitute the basis of a Phase I gene therapy clinical trial in MTM and GSD patients consistent with the IRDiRC objectives to provide 200 therapies for rare disease by 2020. MYOCURE applies to 'PHC14 New Therapies for Rare Diseases' and advances the development of a new therapeutic option for patients suffering from these rare inherited muscle diseases, as well as related preclinical research and animal model development.

Keywords: gene therapy,adeno associated viral vector,myotubular myopathy,pompe,glycogen storage disease,atmp,molecular evolution,computational design,muscle,heart
Superconducting memristors for memory and neuromorphic applications (SUPERMEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France,France
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-10-01
End date: 2023-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The concept we aim a proving is a novel type of electronic device, a redox superconducting memristor, whose functionality is beyond that of binary memories: it shows a continuum of states (instead of just two), and the switching between them can be driven by a sequence of voltage pulses or by visible light illumination. Furthermore, it is based on high-temperature superconductors, allowing for low-dissipation devices. This concept stems from recent work in the frame of an ERC consolidator grant, which has demonstrated the physical mechanism that produces the memristive behavior: a controlled red-ox reaction. The structural simplicity of the proposed memristor radically improves scalability and facilitates fabrication as compared to the existing approaches. The new functionalities it brings, particularly photosensitivity and the superconductivity, open new avenues in the areas of application, which include neuromorphic computing and superconducting electronics.

Keywords: high tc superconductors,memristors,oxide interfaces,redox
Global-Warming-Optimized Aircraft Design (GLOWOPT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Netherlands
Call: Aircraft Design Optimisation providing optimum performance towards limiting aviation’s contribution towards Global Warming (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-09-01
End date: 2022-12-31
Duration (months): 40.0
Total project cost (EUR): 917500.0
EU funding (EUR): 915250.0
Participants: 2
Project status: SIGNED

The high-level objective of the proposed GLOWOPT project is the development and validation of Climate Cost Functions (CCFs) with respect to minimizing global warming and their application to the multidisciplinary design optimization of next-generation aircraft for relevant market segments. Several objectives are set in order to reach this target. The first objective is to provide an overview of the state of the art on the scientific background of the relation between aircraft design and operation and its climate impact. The second objective is to derive characteristic aircraft design requirements, primarily payload and range, based on statistical data analysis of the worldwide aircraft fleet and route structure for future entries into Service using a comprehensive air traffic forecast model. The third objective is to develop climate cost functions for the use in the aircraft design optimisation, which reliably represent the climate impact of CO2, NOx, H2O emissions, as well as contrail-cirrus effects. The fourth objective is to perform a Multidisciplinary Design Optimization with respect to the climate cost function to find a set of operational parameters, design parameters and aircraft technologies that minimize the climate impact of the aircraft design using an existing MDO environment that applies the developed CCFs as objective function. The fifth and final objective is to perform an assessment of the aircraft designs chosen in order to quantify their impact on important metrics such as landing and take-off noise, emissions and cash operating cost. For this purpose, a higher-fidelity simulation integrating existing flight performance, emission and climate impact models is adapted and applied to simulate the aircraft design solution in an operational environment.

Keywords: aircraft design,climate impact,global warming,non co2 effects,contrails,water vapor,nitrogen oxides,climate cost functions