Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mathematical Insights into Dynamics of Incompressible Turbulence (MIND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1497540.0
EU funding (EUR): 1497540.0
Participants: 1
Project status: SIGNED

The unifying goal of the MIND project is to enhance the mathematical understanding of turbulence in incompressible fluid mechanics. Turbulence represents one of the most profound unsolved problems in classical physics, giving rise to numerous deep mathematical challenges. The research is structured around two major interconnected objectives. The first focuses on linear advection-diffusion equations with singular velocity fields, exploring key quantitative aspects such as mixing, enhanced dissipation, and anomalous dissipation. These mechanisms, often easier to isolate and study in linear systems, are crucial for understanding energy transfer and the development of small-scale structures in turbulent fluids. The second goal addresses nonlinear dynamics in incompressible fluid systems, particularly the Euler, Navier-Stokes equations and the Surface Quasi-Geostrophic (SQG) equation. The main focus will be on the study of weak solutions in relevant function classes and their behavior. We will concentrate on qualitative aspects such as well-posedness and uniqueness, as well as quantitative aspects like gradient growth and anomalous dissipation.

Keywords: flows associated with nonsmooth velocity fields convex integration in fluid dynamics
Out-of-field neutron dosimetry for FLASH therapy based on SiC sensors (SiCNeutronFlash)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: SIGNED

Cancer is a major public health problem worldwide. According to the latest research, 20% of people will develop cancer at some point during their lifetime. Radiotherapy (RT) is the medical use of ionizing radiation to treat cancer. About 52% of cancer patients receive RT at least once during their treatment. During the last years, new RT treatment modalities are rapidly being researched, one of the most promising is the Ultra High Dose-Rate Radiotherapy (UHDR) or FLASH therapy, where the delivered dose rate is several orders of magnitude higher than the conventional one. This approach has been found to elicit significant sparing of healthy tissues with equal probability of tumor control. One of the challenges to validate and enable the clinical implementation of FLASH is the development of active dosimetry systems that allow accurate dose measurements and beam monitoring. The experience gained in RT traditional treatments shows that secondary neutrons can produce a not insignificant undesirable parasitic dose to healthy tissue and critical organs that can induce late effects. Therefore, the measurement of neutron flux and its spectrum is key to determining potential risks in FLASH therapy. The goal of this project is the development of a novel matrix of active neutron dosimeters based on Silicon Carbide (SiC) diodes covered with different types of neutron conversion layers and moderators for characterizing the neutron contribution out-of-field in FLASH conditions. SiC has many advantages, e.g., low noise, insensitivity to visible light and temperature variations, higher radiation hardness than silicon. The host group has been the first worldwide in obtaining a SiC detector with a linear relationship between the charge collected and the dose up to 11 Gy/pulse (1.5 um pulse). To the best of our knowledge, there are no active neutron dosimeters to measure out-of-field neutron doses in FLASH conditions. We propose to create the first one in the field.

Keywords: flash therapy,sic radiation detectors,neutron dosimetry
Improvising Europe: Jazz, Cultural Globalisation and the Reinvention of Multiethnic Identities (IEJCGRMI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

The research project focuses on issues of musical socialisation, cultural assimilation, financial strategies and gender inequalities within the jazz scenes of three major European cities: Barcelona, Budapest and Manchester. These three cities are illustrative of fundamental changes in the way that contemporary music scenes in Europe are responding to challenges of globalisation and cultural assimilation. This is most apparent in the many hybrid musical forms being developed by Europe’s traditional (Gypsies) and current (immigrant diasporas) ‘quintessential others’ to express cultural identities. Given that each selected scene’s functioning is closely linked to peculiar ethnic and racial characteristics, the three scenes provide compelling examples of the way in which jazz-related cultural practices reflect, shape and reinvent Europe’s cultural landscape. This interdisciplinary research project of transnational comparative scope is expected to generate new knowledge on the contemporary musical expressions of cultural diversity and assimilation strategies through music in Europe, which is essential to design projects that enhance intercultural dialogue. The following questions will guide the project: How do musicians construct the trajectory of their musical (dis)tastes and how it relates to their socioeconomic status? How does improvised music function to achieve cultural assimilation and (at the same time) to maintain distinctions linked to ethnicity, race and gender? How does gender become a relevant factor in acquiring prestige? What types of economic and artistic strategies do musicians develop to achieve artistic autonomy? Throughout the fellowship, the ER will conduct 35 in-depth interviews with mixed-background jazz musicians, undertake ethnographic fieldwork at eight venues, submit two articles, present at five conferences, organize academic workshops and design an international series of popular science events to further disseminate the results.

Keywords: jazz diasporas,transnational distinctions,hybridity,cultural diversity,cultural difference,musical socialisation,multi ethnic relations,assimilation,
Clinical readiness of a live biotherapeutic for treatment of Non-Small Cell Lung Cancer (NSCLC) (PB_LC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2025-08-31
Duration (months): 32.0
Total project cost (EUR): 1881875.0
EU funding (EUR): 1881875.0
Participants: 1
Project status: SIGNED

Non-small-cNon-small-cell carcinomas (NSCLC) represent 80-85% of the worldwide lung cancer cases, which are the leading cause of cancer-related death. Several clinical trials have indicated better survival rates in NSCLC patients treated with immune checkpoint inhibitor (ICI) antibodies targeting PD-1/PD-L1 or CTLA4. However, since many patients display innate or acquired resistance to these therapies, there is a pressing need to discover methods to help them overcome the resistance. Founders of Pulmobiotics, a spin-off created as a result of an ERC PoC project, have shown their ability to engineer and produce a non-pathogenic strain of the mild human lung pathogen Mycoplasma pneumoniae (the MycoChassis), used to stimulate the immune system to promote T cell infiltration in the tumor. The developed MycoChassis also secretes different immunomodulators (IL2, IL12, and Flt3L) in a sustained and local manner directly to the lung tumor, overcoming their high systemic doses of toxicity in patients. Pulmobiotics has further optimized the MycoChassis to meet safety requirements, engineered a development candidate product (PB_LC) for lung cancer treatment, and developed analytical methods to analyse its replication and biodistribution in vivo, critical regulatory requirements. The specific objectives of this EIC Transition proposal are to establish processes for manufacturing, formulation, and inhalation delivery of the product that meet GMP standards; to do preclinical regulatory activities (including efficacy, safety, and pharmacokinetics/ pharmacodynamics), as well as to advance the market and business preparation for the commercial exploitation of the first product of the company, PB_LC. Achieving the project objectives will pave the way to take PB_LC into first-in-human clinical trials and license the product to reach the market. The use of PB_LC will positively impact the quality of life of NSCLC patients by increasing the efficiency of currently used immunotherapies.

Keywords: lung cancer,synthetic biology,bio engineering,business development,bacterial therapy,live biotherapeutic products,mycoplasma pneumoniae,cold tumors rescue,immune checkpoint inhibitors
Quantum Annealing for Fluid Antenna MIMO Systems (QUARTO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Cyprus
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Multiple-input multiple-output (MIMO) technology transformed wireless communications. However, the extreme requirements of the envisioned 6G services and the highly complex and dynamic radio environments of next-generation wireless networks call for better exploitation of the spatial channel dynamics and adaptation to rapid channel variations. Fluid antenna systems (FAS) have been recently proposed in response to these issues. They leverage liquid antennas whose position can be adjusted in real-time to enhance reconfigurability and, therefore, improve capacity, reliability, energy harvesting, and interference management. Nevertheless, antenna positions optimization is a particularly challenging problem that cannot be efficiently tacked by conventional means, especially given the excess of possible positions required to unlock FAS potential. Quantum computing alleviates this processing bottleneck. Based on the above, QUARTO Proof-of-Concept (PoC) aims at developing and validating through D-WAVE experimentation a novel FAS-based and Quantum Annealing (QA)-enabled MIMO communication paradigm. QUARTO focuses on establishing the effectiveness of a proposed pre-processing technique for large-scale quadratic unconstrained binary optimization (QUBO) problems, experimentally validating the QA-based antenna configuration solution for FAS-based MIMO systems, demonstrating its benefits in comparison to the state of the art, and exploring its commercial potential. The project will benchmark the pre-processing technique on classical graph problems, such as MaxCut, scaling from 100 up to 2,000 variables, and will test the QA-based solution on MIMO configurations with up to 100 liquid antennas and ports. The proposed solution provides new R&D directions in quantum computing and 6G wireless communication technologies. By integrating QA with FAS-based MIMO systems, QUARTO aims to deliver superior performance and pave the way for future technological breakthroughs.

Keywords: quantum computing,wireless communications,6g,mimo,quantum annealing,quantum optimization
TWINNING COORDINATION FOR ENHANCED SCIENTIFIC CAPACITY IN WATER QUALITY, FOOD SAFETY, TRACEABILITY, AND AUTHENTICITY BY USING INNOVATIVE APPROACHES (SPECTRA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Greece,Italy,Slovenia,Spain,Ireland
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1559340.07
EU funding (EUR): 1492415.43
Participants: 5
Project status: SIGNED

SPECTRA aims to improve AUTH R&I capacities to strengthen its scientific reputation, attractiveness, visibility, and networking channels. SPECTRA will stimulate scientific excellence and innovation in key research areas of Water Quality and Food Safety, Quality & Traceability (WQ&FSAT) for addressing the challenges that emanate from ongoing and accelerating climate changes in Greece. SPECTRA approach will be achieved by a unique combination of research activities, “hands-on” training, academic and non-academic mobilities /courses and workshops on scientific and complementary transferable skills facilitated by the academic-non-academic composition of the consortium. It will reinforce R&I and knowledge transfer capacity of AUTH’s research staff, including its permanent scientists and Early-Stage Researchers (ESR), fostering collaboration between academia, industry, and stakeholders in Greece within a sustainable research framework, promoting international networking, mobility, and integration into the European Research Area (ERA). At scientific level, it is expected to enlarge the community of competitive prestigious researchers at AUTH in WQ&FSAT, stronger and better-connected to a core of international and relevant R&I systems, supported by skilled R&I managers with their international networks. At social level, it is expected an improvement in WQ&FSAT by providing new breakthrough scientific knowledge on quality of water resources, advancing food safety supervision performance, increasing consumer and market confidence in Greek food product safety, facilitating monitoring, inspections, decision-making by competent authorities, and supply chain actors and policymakers and enhancing networking, and engaging with food safety high-level experts. At an economic level, the project will contribute to the development of an innovative WQ&FSAT industry and the profitability of regional companies through new product development, approaches and tools, innovation support, and job creation.

Keywords: water quality,food safety,traceability,and authenticity,mass spectrometry,spectroscopy,capacity building,excellence,
Tools and Instruments for standardized user experimentation (HEARTS-Hop)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Switzerland,Slovenia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 33.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 2
Project status: SIGNED

The main purpose of the HEARTS-HOP proposal is to provide to the HEARTS project standardized tools and instruments for dosimetry and user experimentation and lifecycle management throughout and by the end of the HEARTS project. These developments carried out by Cosylab will provide a significant boost to the activities of preparation of the facilities at CERN and GSI so that they can achieve the foreseen TRL6-7 and, at the same time, pave the way for reaching an even higher TRL right after the project. As a first objective, tools that allow users to have control of the beam during experimentation by acting on a single centralized interface will improve the quality of the service provided at each facility and potentilly increase the scientific and insustrial throughput. Finally, the user lifecycle tool will also boost the TRL of the all HEARTS initiative at a global service level.

Keywords: radiation,electronics,shielding,radiobiology,space,heavy ions,galactic cosmic rays,high energy accelerators
Building individual and community RESilience thrOugh NATurE-based therapies (RESONATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Sweden,Denmark,Netherlands,United Kingdom,Italy,Belgium,Bulgaria
Call: Developing nature-based therapy for health and well-being (HORIZON-CL6-2022-COMMUNITIES-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 5579672.5
EU funding (EUR): 5579672.25
Participants: 14
Project status: SIGNED

RESONATE will bring together a consortium of world leaders in Nature-based Therapy (NbT) research, practice, policy, and innovation with stakeholders in the health, environmental, economic, and societal sectors to: a) build a stronger causal evidence base of the links between nature, health, and well-being by demonstrating nature’s biopsychosocial resilience building capacities; b) demonstrate how multi-sectoral stakeholders can collaborate to implement locally acceptable and inclusive NbTs; c) increase awareness and acceptance of these benefits among the public, multi-sectoral stakeholders, and policy makers; and d) ensure wider utilisation of cost-effective NbTs, to help build more resilient individuals and communities in urban, rural, and coastal settings. This will be achieved through an on-line Global Systematic Map of existing NbTs, and nine Case Studies (CSs) using longitudinal cohorts, Randomised Controlled Trials, and a Community of Practice trial, spanning 8 countries, urban, rural, and coastal settings, and all three levels of the health promotion/disease prevention pyramid. CSs will collect sector-specific and process-related data spanning four sectors: health, environment, economy, and society. Outcomes will include effectiveness, mechanisms, equity (fairness/inclusivity), environmental sustainability, cost-effectiveness, and social acceptability. Selected CSs will develop Social Innovation Action “Nature-based Resilience Hubs” to demonstrate best practice cross-sectoral collaboration and market potential. Results will be synthesised to give insights into scaling-up/scaling-out potential, and summarised in a Toolbox of practical Guides and Tutorials aimed at different end-users, as well as an overall “What Works Nature-based Therapy Guide” for NbT implementation at scale (i.e. Impact). An International Expert Advisory Board of world leaders in NbTs will support integrated communication, dissemination, and exploitation activities for maximum reach.

Keywords: public health and well being nature based therapies biopsychosocial resilience social innovation actions network nature task force
Untapping multiparametric 2D luminescence sensing through MACHine LEarning and Spectral Sorting (MAtCHLESS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain,Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Cellular organisms are complex machines whose health and functioning are dictated by parameters including temperature, oxygen concentration, and pH. Luminescence nanosensing is a technology that promises all the features required to reliably monitor these parameters at the intracellular level: minimal invasiveness, remote working principle, and submicrometric spatial resolution. These features are ensured by the use of sub-micrometric sensors (particles) whose luminescence is sensitive to changes in the parameters to be sensed. Yet, despite the hype about luminescence nanosensing, its reliability in the study of cells is limited by interparticle variability in optical properties and sensing performance, simultaneous response to several parameters (cross-sensitivity), and lack of a measurement technology that enables fast 2D mapping of multiple parameters with sub-second temporal resolution. MAtCHLESS tackles heads on these limitations to develop a reliable luminescence sensing technology for multiparameteric sensing in cell studies. This project entails: design of a novel family of composite submicrometric luminescent sensors, elimination of interparticle fluctuations in optical properties using a spectral sorting strategy, introduction of the paradigm shift of making cross-sensitivity a desirable feature via machine learning, and use of a novel optical technology to build a setup for 2D mapping of multiple parameters with high temporal and spatial resolution. MAtCHLESS will test the reliability of the sensing approach in mammalian cell lines and extremophiles – microorganisms that can withstand extreme conditions of, e.g., temperature, oxygen concentration, and pH. These investigations will show the potential of the developed technology to monitor both slight and extreme changes in biological parameters, towards a deeper understanding of, e.g., how cancer can be more effectively treated, as well as how Life evolved on Earth and can be adapted beyond our planet.

Keywords: luminescence sensing,submicroparticles,machine learning,intracellular