Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mainstreaming Gender in the European Union after the Financial Crisis (MGINEUAFC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2016-05-01
Duration (months): 24.0
Total project cost (EUR): 175974.6
EU funding (EUR): 175974.6
Participants: 1
Project status: CLOSED

This proposed project aims to contribute to excellence in the field of feminist political science by developing methodologies which help us to understand the gendered political dimensions of recent EU macro economic policies to the Eurozone/financial crisis. Gendered research on this policy area is under developed and difficult to undertake on account of well documented methodological shortcomings in feminist political science. The fellow brings an innovative methodology developed in their recently competed thesis which tackles these shortcomings and will apply it to these under researched policy areas. Activities during the IEF include a period of training and learning on this policy area, which the fellow is not yet expert in and a period of fieldwork in Directorate General for Economic and Financial Affairs (DG ECFIN). This data will provide insights into the processes leading to the implementation, or rejection of gender mainstreaming within DG ECFIN. Empirical findings will be published in specialist EU studies and gender academic journals, as well as in pamphlets for the policy community around DG ECFIN, including policy consultants. The workplan includes several incremental steps to build capacity around this presently very under researched field and to thus achieve maximum benefit for the ERA. These include the production of a methodological article illustrating techniques to undertake gendered analysis in these areas; an initial workshop to explore these methods and themes at the host institution; and a joint edited special edition on the gendered implications and policy making processes of the EU's policy responses to the Eurozone/financial crisis. This will be followed by an ECPR Joint Sessions Workshop a year later. Papers from this workshop will be edited into a a book after the completion of the IEF. These publications and activities will build capacity in the ERA and will help the fellow establish a leading position within this emerging field.

Keywords: s109 political systems - legitimacy of governance,s112 global and transnational governance - international law - human rights
Monitoring of Structural Performance (MOSP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-11-01
End date: 2015-10-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The proposal has symbiotic parallel objectives in career development and technical innovation. On the career development side the objective is to support the fellow in attaining a leading independent position after the fellowship. The technological objective is to develop the next generation of bridge monitoring technology. The fellow has 10 years postgraduate experience in both research and industry. He has completed his PhD in Ireland. The topic of his PhD was the Structural Health Monitoring (SHM) of bridges. A number of novel findings were uncovered in the course of the research, as evidenced by the 4 journal & 3 conference papers resulting from the work. The host organisation is the Vibration Engineering Section (VES) at the University of Sheffield. The Scientist in charge is Professor James Brownjohn who has 25 years experience in structural monitoring, an outstanding publication record and has been principal investigator for more than €2m worth of funding since 2005. The technological aim of the proposal is to develop a technically advanced system to support bridge decisions e.g. need for maintenance, traffic restrictions or closure. This will be achieved by combining the SHM experience of the fellow with the multidisciplinary expertise of the VES, in particular their competency in sensors, field testing and data fusion. In terms of career development the fellow has many of the skills necessary to achieve a position of professional maturity as evidenced by being interviewed for lecturing positions in 4 universities this summer. However for the researcher to make a significant impact internationally, he needs to develop competencies in a number of key areas such as structural instrumentation, data fusion & proposal writing. In VES he will have to learn leading edge technologies very fast in real world conditions. This will be supplemented by specialist training courses to address any remaining skills that have been identified as needing development

Keywords: civil engineering,simulation engineering and modelling
Aiding the Neglected: Meta-Analysis of Emotional Maltreatment Prevention and Intervention Programs (AIDING THE NEGLECTED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-03-01
End date: 2016-10-02
Duration (months): 36.0
Total project cost (EUR): 264711.0
EU funding (EUR): 264711.0
Participants: 1
Project status: CLOSED

Emotional maltreatment has been called the most elusive and damaging of all types of maltreatment for a child, and represents the core issue and most destructive factor across all types of child abuse and neglect. This characteristic of negative parent-child relationship has recently received scientific attention with acknowledgments that such neglect the most frequent forms of maltreatment experienced by children and adolescents and has detrimental mental health consequences. With attention given to employment of evidence-based programs as programs with proven effectiveness, examining the effectiveness of various programs for emotional maltreatment is of high theoretical and practical importance. Programs that target other forms of child maltreatment have been subject to several meta-analyses. However, the effectiveness of programs for emotional maltreatment has not been examined under the lens of meta-analysis, and are thus still under much debate. Implementation of meta-analysis in this stage of saturated research on the emotional maltreatment is a crucial step in the further understanding of this phenomenon, and will enable concluding imperative theoretical and practical implications. Thus, the objective of the proposed research project is to conduct a meta-analysis of the effectiveness of identification, prevention and intervention programs for emotionally maltreated children. Beyond its practical implications (e.g., pointing to identification and treatment programs that are evidence-based), the proposed research may offer a theoretical contribution, heretofore unapplied, to the understanding of parental practices that have the most crucial impact on the child’s holistic well-being: mental and physical. This study will be conducted in the Berkeley School of Public Health, under the guidance of Prof. Ozer and in collaboration with Prof. Lieberman form UCSF and Prof. Katz from U. of Washington.
Numerical Characterization and Modelling of Syngas Combustion (SYNGAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-21
End date: 2015-10-20
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

In order to meet the EU targets on renewable energy and greenhouse gas emissions, there is an urgent need to increase the use of renewable fuels such as syngas and biogas. In the mean time, the low efficiency and emission problems associated with non-premixed combustion systems are also driving the move away from such systems towards lean premixed conditions where fuel is mixed with excess air prior to combustion. Despite substantial progress achieved in turbulent combustion, there still lacks the understanding of the following four phenomena in the context of premixed mode: (i) development of flames (ii) influence of high-pressure on turbulent burning velocities, (iii) preferential diffusion effects which are most pronounced in mixtures that contain free hydrogen, and (iv) flame quenching by very intense turbulence is still poor. The project is aimed at numerically characterizing the burning behaviour of premixed syngas and biogas combustion and developing large eddy simulation (LES) techniques to facilitate the study and design of practical combustion systems for such sustainable fuels. The main objectives are: • To carry out numerical investigations of the aforementioned three important phenomena, i.e. (1) development of syngas premixed flames; (2) influence of high-pressure on turbulent burning velocities; and (3) preferential diffusion effects. • To develop a turbulent reacting flow model that captures the underlying physical and chemical processes in flame development, the pressure and Lewis number effect; and to • To validate the numerical model with published experimental data. The project will result in a validated LES based predictive tool within the frame of open source CFD code OpenFOAM for multidimensional numerical simulations of syngas/biogas premixed flames under elevated pressures as well as a comprehensive database on the values of the time scale, computed for different mixture compositions, pressures, and temperatures.

Keywords: g306 energy systems,g301 aerospace engineering,g302 chemical engineering - technical chemistry
Aerographite as scaffold material for regenerative medicine (GRAPHITE4MED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

We propose an interdisciplinary project with the objective to explore the feasibility of aerographite as scaffold material for tissue engineering in regenerative medicine with special focus on directed cell growth. Aerographite is a novel carbon based material that consists of a seamless interconnected network of microtubes. The project is motivated by promising developments of related carbon materials (carbon nanotubes and graphene) in biomedical applications. Aerographite is a potential candidate for tissue engineering, as it can be fabricated in a highly controllable manner to create various macroscopic 3-D shapes. Tailored microarchitectures can be realized that offer penetrability and accessibility of surfaces. These features are key factors for 3-D tissue growth. The 2-year project will be realized in three stages: 1. Material characterization and chemical surface modification to impart aqueous compatibility, 2. Biofunctionalization for specific cell adhesion, and 3. Quantification of cell adhesion and growth on functionalized scaffolds. All tasks are highly interdisciplinary and combine aspects of materials science, chemistry, biology and biophysics and medicine as evident in the variety of analytical techniques that will be employed. Aerographite structures and their functionalization will be investigates with Raman spectroscopy, scanning electron microscopy (SEM), scanning probe microscopy (SPM), and contact angle measurements. SPM, confocal fluorescence microscopy and environmental SEM will be used to assess cell growth on aerographite. Biological assays will be applied to evaluate biocompatibility and cytotoxicity. For the success of the project the applicant can profit from her previous collaborations with European research groups and the excellent research environment at the host university. New collaborations and acquisition of new skills and knowledge will complement her scientific profile and enable her to start a junior group in the near future

Keywords: g314 medical engineering and technology,materials science,aerographite,biocompatibility,biofunctionalization,cell culture,tissue enigineering
Terahertz Imaging and Spectroscopy for Cultural Heritage (TISCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-02-17
End date: 2016-02-16
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The purpose of this proposed project is to establish terahertz technology as a viable, nondestructive, and noninvasive tool for the study of cultural heritage; which will contribute to the conservation and sustainability of artifacts. Terahertz spectroscopic imaging is a nascent technique—established only in the last 20 years, and developed only in the last five years for cultural heritage applications. As a result, its utility to conservation has not been extensively demonstrated, despite its exhaustive potential. Through this project, decisions can be made related to which terahertz tools provide complementary information to well-established measurement techniques and what information cannot be extracted using any other technique, while preserving the condition of the artifact of interest.

Keywords: p108 optics,s412 cultural heritage,s401 archaeology - archaeometry - landscape archaeology,s310 history of art and architecture,p116 metrology,p109 lasers,g207 signal and image processing
Cone snail toxins as therapeutic agents: Decoding biological mechanisms of conotoxin folding (CONBIOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-05-01
End date: 2017-03-31
Duration (months): 36.0
Total project cost (EUR): 294456.3
EU funding (EUR): 294456.3
Participants: 1
Project status: CLOSED

Predatory marine cone snails use extraordinarily complex venoms to capture prey. Most of the ~500,000 biologically active venom components are small, disulfide-rich peptides called conotoxins. They target receptors and ion channels of the nervous system with remarkable potency and specificity. Due to their enormous diversity and target specificity, conotoxins have become invaluable tools in molecular pharmacology and as therapeutic agents. However, their chemical synthesis is hampered by multiple disulfide bonds and additional post-translational modifications, which result in low folding yields and accumulation of aggregated or misfolded products. Recently observed differences between in vitro and in vivo synthesis strongly indicate that folding and modification of conotoxins in the endoplasmic reticulum of the venom glandular cells are tightly regulated processes. Understanding mechanisms that govern the proper assembly of conotoxins at a molecular level is a prerequisite for designing more efficient production systems for conotoxins and other disulfide-rich peptides of biological and pharmacological importance. By using next-generation sequencing, bottom-up proteomics, protein-protein interaction and molecular silencing technologies, this study will elucidate crucial pathways for the oxidative folding and modification of conotoxins. These results will be used to develop a cell-based expression system for conotoxins that are difficult or impossible to synthesise chemically, thus providing novel agents for pharmacotherapeutic studies. While our knowledge on the proper folding of larger protein substrates is constantly improving, research into the generation of small, disulfide-containing peptides is a newly emerging field. By bringing together world-leading scientists in conotoxin pharmacology and protein folding, this project will develop excellent scientific and leadership competences at a high level for a young talented European scientist.

Keywords: peptide biosynthesis,conotoxin biochemistry,l105 protein synthesis - modification and turnover,l306 organelle biology
Inter-hemispheric Coupling of Abrupt Climate Change (INTERCLIMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-04-14
End date: 2016-04-13
Duration (months): 24.0
Total project cost (EUR): 230809.8
EU funding (EUR): 230809.8
Participants: 1
Project status: CLOSED

The primary goal of the proposal is to advance understanding of the governing mechanisms and inter-hemispheric coupling involved in abrupt climate change. Abrupt climate change involves complex non-linear interactions between all components of the global climate system. Such changes have been caused by natural factors in the past but could in the future be triggered by anthropogenic forcing. The proposal will exploit past abrupt change in order to inform on future risks. We propose to synchronise the Law Dome (Antarctica) ice core record to the state-of-the-art Greenland ice core chronology (GICC05) during the most prominent abrupt climate change within the current interglacial period (the ‘8.2 ka event’) and also during the sequence of abrupt climate changes which preceded the last deglaciation. The core offers unrivalled temporal resolution and dating precision for a southern hemisphere record. Rapid global variations in methane gas concentration will be used as dating ties for these synchronisations. The project will lever from the accurately dated Law Dome record to obtain a broad inter-hemispheric view of abrupt climate change. The palaeoclimate data will be interpreted alongside transient climate model simulations of abrupt climate change and integrated with those simulations. The applicant has strong experience in interpretation of southern hemisphere records and in the synthesis of palaeoclimate data. The modeling component of the project and hosting at the leading European centre for the study of Greenland records of abrupt climate change will broaden his expertise and cement his international research career. The new skills brought to Europe and multidisciplinary approach of the project offer strong potential to catalyse lasting collaborations and advance our ability to model future climate change and project its risks to social, economic and natural systems.

Keywords: v101 environment and sustainability,v201 meteorology - atmospheric physics and dynamics,v201 paleoclimatology - paleoecology,abrupt climate change,tipping points,law dome,greenland,ice core
Role of DNA methylation in the regulation of lincRNAs in Hematological Malignancies (LINCMHEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-09-01
End date: 2016-08-31
Duration (months): 36.0
Total project cost (EUR): 352823.7
EU funding (EUR): 352823.7
Participants: 1
Project status: CLOSED

Traditionally, cancer researchers have focused their best efforts on studying the genetic alterations affecting the coding genes. Subsequently, it was observed that in addition to genetic alterations, epigenetic alterations affecting coding genes play an important role in tumor development. In the last decade, largely due to the ability to sequence the human genome and the observation that much of the genome is transcribed but not translated, genes known as "non-coding RNAs" (ncRNAs) have attracted great interest in relation to their biological functions and their role in human tumors. In addition to the small ncRNAs like miRNAs, is also revealing that the human genome also encodes numerous long non-coding RNAs (lncRNAs). Some of these lncRNAs are being found in the intergenic regions of the genome (long intergenic non-coding RNAs - lincRNAs). It is estimated that there may be more than 8000 lincRNAs in the human genome. The mechanism that regulates these lincRNAs and the functional mechanism of the vast majority of these lincRNAs are not known, but the few that have been studied are known to exert their function in the nucleus and to be involved in chromatin remodeling and transcription regulation. The expression of lincRNAs is altered in cancer, playing an important role in the initiation, prognosis and progression of human neoplasies. In this regard, preliminary results from our group show that DNA methylation may play an important role in the regulation of lincRNAs and probably in the pathogenesis of hematological malignancies. For all these reasons, the objectives of this “LincMHeM” proposal are to determine whether inappropriate DNA methylation is involved in regulating lincRNA expression, and if such deregulated lincRNAs are involved in pathogenesis and are potential therapeutic targets for treating B cell hematological malignancies (multiple myeloma, lymphoma and acute lymphoblastic leukemia).

Keywords: l101 molecular biology and interactions,l208 epigenetics and gene regulation,l406 cancer and its biological basis