Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Superconductor-Based Readiness Enhanced Magnetoplasmadynamic Electric Propulsion (SUPREME)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Netherlands,Austria,Germany
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-06-01
End date: 2025-11-30
Duration (months): 30.0
Total project cost (EUR): 2499995.75
EU funding (EUR): 2499995.75
Participants: 5
Project status: SIGNED

High-power electric propulsion technology is needed to enable the sustainable realisation of emerging market applications such as On-Orbit Servicing, in-space cloud computing, debris removal and cis-lunar infrastructure. However, relevant technologies, in terms of cost-effectiveness, sustainability, and performance, are not yet available. The commercialisation of new markets requires more scalable and flexible propulsion solutions. Applied-Field Magnetoplasmadynamic (AF-MPD) thrusters are a robust, efficient, and scalable Electric Propulsion technology, especially suited for high-power operations thanks to their high thrust levels and power densities. These benefits have motivated their widespread research since the 1960s. The main development limitations have been the thruster lifetime and flight readiness imposed by the use of conventional copper magnets for generating the applied field. These problems can be overcome with the use of High-Temperature Superconductors (HTS), which can provide the required magnetic field for AF-MPD operation in a compact and lightweight system. Under the leadership of NSS, a start-up commercialising HTS applications in space, SUPREME aims at increasing the flight proficiency of AFMPD by demonstrating the integration of HTS coils and all necessary supporting subsystems in a relevant environment, and the corresponding increase in thruster performance and lifetime. SUPREME also aims to validate the commercialisation potential of the technology by generating a well-defined business model for achieving sustainable revenues and upscaling of production. The consortium is completed by 2 RIs, an innovative SME, and an OEM. On the academic side, both USTUTT and UT are institutes working at the forefront of disruptive R&D in the key areas of EP, space cryogenics, and HTS systems. PEAK represent a key part of the supply chain for propellant tanks, and Airbus’ will contribute as both a supplier and potential first adopter of the technology.

Keywords: electric propulsion,high temperature superconductors,magnetoplasmadynamic thrusters,cryogenics,space propulsion,on orbit servicing,plasma,orbital debris mitigation,interplanetary spacecraft,
Taming dynamic complex media for imaging, communications and photonic computing (ModeMixer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2269619.0
EU funding (EUR): 2269619.0
Participants: 1
Project status: SIGNED

The turbulent atmosphere, flexible optical fibres, and living tissue, are all examples of opaque materials that change in time. Light propagating through these moving complex media is subject to intricate dynamic scattering effects: transmitted optical fields are unrecognisably distorted in space and time. Such phenomena permeate real-world imaging and communications technologies. They prevent microscopy deep into living tissue and hinder both free-space and fibre-optic data transmission. My vision is the realisation of optical technology that automatically configures itself to dynamically ‘cloak’ unwanted scattering effects of any opaque medium it is coupled to – making it possible to look through to an unobstructed view of scenes on the other side. The multimodal nature of this challenge calls for a raft of new sensing and light control techniques. The aim of this proposal is to develop these technologies. I have begun to take some of the first experimental steps to achieve these goals: I have developed a new form of adaptive optics that suppresses temporal rather than spatial light distortion. I have also implemented prototype adaptive optical inverters, capable of all-optically unscrambling light propagation through multimode optical fibres (MMFs) supporting ~30 modes. My project builds on these concepts, and is delivered through 3 overarching objectives: 1. Real-time monitoring of spatio-temporal scattering in dynamic complex media: Creating dynamic digital twins of complex media that evolve in real-time. 2. All-optically unscrambling dynamically scattered light: Building new types of programmable optical circuit driven by our digital twins to cloak spatio-temporal scattering effects. 3. Applications: reversing the scattering effects of MMFs and atmospheric turbulence; enabling transmission of quantum entangled photons through noisy channels; and finally, investigating the broader implications of our technology to hybrid opto-electronic neural networks.

Keywords: spatial light modulation multiplane light conversion direct laser writing
HYdroGen High pressure supply chain for innovative and cost Efficient distRibution (HYGHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,France,Italy,Slovenia
Call: Demonstration of high pressure (500-700 bar) supply chain (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6769096.25
EU funding (EUR): 4991009.88
Participants: 8
Project status: SIGNED

HYGHER HYGHER aims to improve gaseous hydrogen delivery infrastructure for hydrogen mobility, developing innovative solutions and integrating them optimally along the supply chain steps. These include an innovative filling center able to compress and fill over 2t/day of H2 from green electrolysis, two new high pressure trailers (featuring novel cascading concepts for optimized filling/unloading) each able to transport 1.25 tons of H2 at 500 bar, and HRS adaptations for full valorization of high pressure H2, increasing economic and technical advantages. The 14-month demonstration will take place in the region of Paris to supply the HYPE fleet of hundreds of FCEV taxis with locally produced H2 via a network of HRS, reinforcing EU H2 infrastructure along TEN-T corridors. A strong reduction in CAPEX, OPEX and footprint will be demonstrated, thus reducing the price of hydrogen at the nozzle. The project will pave the way for replication of the solution via standardization efforts including a generic design of component interfaces, as well as recommendations on regulations and standards to simplify future implementations. Safety will play a central role, through the involvement of H2 safety experts. Circularity aspects will be studied and applied to progress toward a sustainable supply chain. Throughout the project, a future upscale of the solution to higher pressures and capacities will be prepared and all requirements regarding design, safety, economic, and regulatory aspects identified. Related requirements and challenges will be discussed with an Advisory Committee and with a wide panel of stakeholders. This will strengthen collaboration, raise awareness about potentials and benefits of the high pressure HYGHER solution, and accelerate replication and scale-up. To foster market uptake, 6 replications will be initiated in the scope of the project. HYGHER will accelerate the development of 3 SMEs, thus contributing to consolidation of EU leadership in H2 technologies.

Keywords: hydrogen,hydrogen distribution,hydrogen refuelling station,hydrogen mobility,hydrogen infrastructure,hydrogen compression,metal hydride compressor,hydrogen trailer,high pressure,demonstration
Gas-Phase Sono-Photonics (GASONIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Over the past decades, modern photonics has evolved from a niche activity to a field of utmost scientific and economic importance. Strikingly, photonic devices ranging from lenses and fibres to complex machines such as lasers and microscopes rely almost exclusively on tailored interactions of light with solid matter. This fundamental principle imposes constraints, limiting e.g. the wavelength range of photonic devices due to absorption and the optical power due to damage. In a ground-breaking effort, we recently opened up an entirely new route to transfer photonic methods from solids to the gas phase: using intense ultrasound (sono) waves, gases can be tailored to enable light control. Building on this pioneering work, I will consolidate a new research field: Gas-Phase Sono-Photonics. Within GASONIC, I will develop solid-state free light guiding concepts ranging from simple light deflection in density-modulated gases to all-gas-phase damage-immune sono-photonic waveguides shaped by intense acoustic waves. Gas-phase light deflectors will enable innovative ultrafast optical switches to modulate, sample and stack laser pulses approaching the terawatt regime. Sono-photonic fibres will enable a whole new field for guided optical wave control, complementing established wave-guiding concepts. Moreover, by providing a direct link between advanced optics and electronics mediated by gas phase acoustics, sono-photonic methods will open up new degrees of freedom for light control including adaptive control schemes leveraged by intelligent optimisation routines. The proposed efforts will thus extend photonic methods into entirely new regimes, opening the door to adaptive light control at unprecedented power levels and in unexplored spectral regions. GASONIC thereby addresses key limitations in several fields including high-field physics, imaging, attosecond and accelerator sciences while prospectively opening new opportunities for fibre lasers and power-over-fibre methods.

Keywords: acousto optics,ultrasound technology
Mechanical Characterisation of Nucleic Acids using Single Molecule Methods (MeCHaNiSM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,Netherlands,Ireland,Spain,Belgium,Germany
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4085935.2
EU funding (EUR): 4085935.2
Participants: 13
Project status: SIGNED

Nucleic acid (NAs)-based therapies have started to yield major advances in the treatment of human disease. New approaches for understanding NA structure and function are required to extend the boundaries of today’s gene editing technologies, cancer therapies, and mRNA vaccines. Single-molecule techniques have revolutionised our understanding of NAs and their interactions with therapeutic oligonucleotides, small molecules, and proteins. However, for Europe to remain competitive in this area, new expertise is urgently required in single-molecule NA analysis, which intersects the fields of physical chemistry, biophysics, NA synthesis, and computation. MeChaNiSM will train the next generation of European scientific leaders in the development and use of single-molecule biophysics techniques where they will investigate critical interrelated question regarding the structure, dynamics, function, and interactions of NAs. To do this, our Doctoral Candidates (DCs) will: - Unravel high-resolution NA structures and intramolecular forces with modified bases - Understand the conformation and dynamics of NAs at the single-molecule level - Develop next-generation therapeutics for treating genetic diseases MeChaNiSM connects world-leading researchers working in the fields of single-molecule biophysics, NA chemistry, and computational modeling with outstanding industrial partners working in complementary fields. In addition to conducting world-class research, our DCs will understand industrial needs, have know-how in running multidisciplinary research, and will be immersed in a broad collaborative network connecting academia and industry. Our DCs will provide vital future breakthrough applications in NAs and single-molecule analysis to pharmaceutical and biotechnological industries where the design of new drugs - including NA-based therapeutics and vaccine technologies - will provide major improvements to human health.

Keywords: single molecule analysis,nucleic acids,drug development,rna,dna,modified nucleobases,fluorescence,conformational dynamics
Exploiting Transcriptional Adaptation to Develop New Genetic Compensation-based Therapies (TA2TRSQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Organisms display various mechanisms to compensate for the deleterious effects of harmful mutations. One such mechanism is transcriptional adaptation (TA), a recently identified mode of gene regulation whereby mutant mRNA decay triggers the transcriptional modulation of so-called adapting genes, independently of protein loss (Rossi et al., Nature 2015; El-Brolosy et al., Nature 2019). In some cases, TA can lead to functional compensation by upregulating genes that are functionally redundant with the mutated gene. In our funded project, Transcriptional Adaptation and Genetic Compensation (TAaGC), we are investigating the mechanisms underlying TA and its relevance to human health and disease. We have now observed TA in human cells and found that splice-switching antisense oligonucleotides (ASOs) can be used as tools to induce TA (Falcucci et al., Nature 2025). By causing the skipping of out-of-frame exons, these ASOs disrupt the reading frame, thereby triggering mutant mRNA decay and the upregulation of functional paralogs. Using this approach, we have induced the upregulation of functional paralogs for both the DMD and LMNA genes, mutations in which cause Duchenne muscular dystrophy and laminopathies, respectively. ASOs have been approved by regulatory agencies, including the FDA, for the treatment of multiple diseases, altogether suggesting that splice-switching ASOs constitute a viable therapeutic approach to induce functional compensation via TA. In this PoC project, we first aim to further optimize the sequence of TA-inducing ASOs for DMD and LMNA in human and mouse cells in culture. The optimized human ASOs will then be fully investigated in relevant human cells in regards to their effect on the transcriptome and proteome; the optimized mouse ASOs will be tested in wild-type and mutant mice. Together, these studies will identify lead ASO candidates ready for further preclinical and clinical development in the treatment of DMD and laminopathies.
Neuronal control of fascia (NEUROFASCIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

The fascia is the largest tissue in the body, yet most of us never heard of it. This connective tissue delineates the skin, surrounds muscles, and closely envelops all organs. Clinically, it is mainly considered a mechanical barrier separating organs and muscles. But why should a simple barrier be populated with immune cells and receive extensive innervation by sensory and sympathetic neurons? Here we propose that the fascia generates a sensory platform that detects damage to the tissues it envelops and communicates this information to the brain which in turn, initiates corrective programs and modulates immune activity. Our preliminary results support this hypothesis indicating that chronic depression in mice and direct optogenetic activation of sympathetic fascia innervations induce immune changes in the fascia. We propose three major aims: A) Characterization: Identify the anatomical and genetic characteristics of fascia innervation and fascia resident immune cells B) Function: Determine how fascia inflammation is represented in the brain and how it affects pain responses C) Modulation: Demonstrate how neural control of the fascia affects this tissue and its immune state My multidisciplinary background uniquely positions me to study this novel aspect of brain-body communication. We will use viral tracing and spatial transcriptomics to characterize the fascia’s innervation; optogenetics to locally control neurons in the fascia; chemogenetics to manipulate brain activity; and high-dimensional immune characterization to establish the immunological outcomes in the fascia. NEUROFASCIA has the potential to transform our understanding of brain-immune communication and open new therapeutic avenues for disease such as myofascial pain syndrome, endometriosis, and fibromyalgia, which are accompanied by low-grade inflammation and altered fascia innervation.

Keywords: connective tissue,sympathetic nervous system,interoception
Adaptive strategies for enhancing threat-agnostic resilience of port ecosystems (PORTAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Italy,Greece,Germany,Portugal,Spain,Ireland,United States
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 2138554.29
EU funding (EUR): 1803600.0
Participants: 11
Project status: SIGNED

PORTAL is pioneering an innovative, threat-agnostic framework to pre-empt cascading losses and establish resilience benchmarks with fit-for-purpose adaptation measures to proactively mitigate negative impacts on Port Infrastructure and interdependent Socio-eCOlogical systems (PISCO). PORTAL’s vision is important as ports handle 75% of the EU's trade, and face rising climate challenges, with $7.5 billion in global annual losses due to multi-hazard risks. In doing so, we deliver more resilient, inclusive and environmentally friendly PISCO. We do this through innovation, as we will deliver an interdisciplinary, multi-stakeholder inclusive, and scalable approach to optimise PISCO’s resilience and sustainability, with emphasis on people’s needs and environmental benefits. PORTAL integrates cutting-edge technologies such as digital twins and generative AI (GenAI) to enhance sustainable adaptation strategies. This is achieved through tailored designs of win-win solutions, e.g. Nature-Based Solutions (NBS), in inclusive and gamified PISCO. To achieve this vision, PORTAL includes a comprehensive training and capacity building programme embedded within its research, innovation, and dissemination activities. PORTAL leverages interdisciplinary and inter-sectoral secondments to enhance the skills of researchers and professionals through knowledge transfer. We facilitate decision-making to incentivise resilience strategies of PISCO operators, foster a safer environment and advance career development of participants, in line with EU policy goals for digital and green transition. PORTAL outputs include an advanced communication platform empowered by predictive tools, immersive training environments using augmented and virtual reality, and a library of actionable adaptation measures. These tools will empower diverse stakeholders identified through the empirical analysis of Socio-Ecological System (SES) to collaboratively improve environmental sustainability and strengthen resilience

Keywords: climate resilience,critical infrastructure,proactive adaptation,digitalisation,ports
PROMISERS: PFAS FREE POLYMER MATERIALS FOR PROTON EXCHANGE MEMBRANE (PEM)-BASED FUEL CELLS AND ELECTROLYSERS. (PROMISERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,Italy,Sweden,France,Netherlands,Germany
Call: Development of non-fluorinated components for fuel cells and electrolysers (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3853010.6
EU funding (EUR): 2997579.89
Participants: 12
Project status: SIGNED

The PROMISERS project goal lies in the advancement of new non per- and polyfluoroalkyl substances (PFAS) components for PEMFCs and PEMELs utilizing materials based on hydrocarbons and cellulose. The project will achieve this objective by focusing on developing multiple disruptive approaches for ionomers, membranes, electrode inks and MEAs which are free of PFAS. The project is aligned with sustainability principles, with no projected environmental barriers. Sustainable-by-design approaches and non-harmful materials will be targeted to ensure the environmental compatibility. Besides sustainability and zero pollution for the material fabrication also aspects such as safe-by-design, scalability and processing routes will be taken in account. PROMISERS represents a powerhouse consortium, including four major multinational companies: Syensqo (SOF, Chemicals and Polymers), Fumatech (innovative membranes for energy applications), Industrie De Nora (electrochemical industry) and RINA Consulting, two SMEs: Cellfion (sustainable membrane solutions) and Hysytech (engineering), two international research and technology organisations: Leitat, TNO, and an European university: IIT. PROMISERS will deliver and validate short stacks of PEMFC and PEMEL, targeting performances of > 1.5 Wcm-2 at 0.65 V for PEMFC and 3.0 Acm-2 at 1.8 V for PEMEL and with a degradation rate < 5 µV/hr. A techno-economic evaluation and exploitation plan will be executed to move from the technological concept (TRL2) to a laboratory scale multicell-stack (TRL4) PEMFC and PEMEL to ensure a fast-track for its commercialisation.

Keywords: pemfc,pemel,non fluorinated,sustainable,clean hydrogen