Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Seven Nanometer Technology (SeNaTe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Israel,Germany,Germany,Germany,Germany,Germany,Belgium,Hungary,France,France,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,United States,Netherlands,United Kingdom
Call: ECSEL Key Applications and Essential Technologies (IA) (ECSEL-2014-2, 2014)
Start date: 2015-04-01
End date: 2018-03-31
Duration (months): 36.0
Total project cost (EUR): 177731624.33
EU funding (EUR): 31816386.93
Participants: 52
Project status: CLOSED

The SeNaTe project is the next in a chain of thematically connected ENIAC JU KET pilot line projects which are associated with 450mm/300mm development for the 12nm and 10nm technology nodes. The main objective is the demonstration of the 7nm IC technology integration in line with the industry needs and the ITRS roadmap on real devices in the Advanced Patterning Center at imec using innovative device architecture and comprising demonstration of a lithographic platform for EUV and immersion technology, advanced process and holistic metrology platforms, new materials and mask infrastructure. A lithography scanner will be developed based on EUV technology to achieve the 7nm module patterning specification. Metrology platforms need to be qualified for N7’s 1D, 2D and 3D geometries with the appropriate precision and accuracy. For the 7nm technology modules a large number of new materials will need to be introduced. The introduction of these new materials brings challenges for all involved processes and the related equipment set. Next to new deposition processes also the interaction of the involved materials with subsequent etch, clean and planarization steps will be studied. Major European stakeholders in EUV mask development will collaboratively work together on a number of key remaining EUV mask issues. The first two years of the project will be dedicated to find the best options for patterning, device performance, and integration. In the last year a full N7 integration with electrical measurements will be performed to enable the validation of the 7nm process options for a High Volume Manufacturing. The SeNaTe project relates to the ECSEL work program topic Process technologies – More Moore. It addresses and targets as set out in the MASP at the discovery of new Semiconductor Process, Equipment and Materials solutions for advanced CMOS processes that enable the nano-structuring of electronic devices with 7nm resolution in high-volume manufacturing and fast prototyping.

Keywords: semiconductor process,equipment and materials
A unique life-saving smart-watch for high quality, not-invasive, continuous blood pressure monitoring. (BP24)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Human body tries to keep blood pressure as stable and constant as possible, so its instabilities are indicators of systemic problems. Among 1 B people affected by hypertension, however, blood pressure monitoring is ineffective at least in 47% of them, leading to 9 M deaths/year globally. Current monitors for self blood pressure monitoring show main drawbacks: they interfere with daily activities, often lack of reliability and standards, and only allow to measure the blood pressure intermittently, so information on the blood pressure trend is not available. BP24 is a wearable medical device for noninvasive, continuous and highly accurate blood pressure monitoring, specifically targeting patients with hypertension and inpatients. Vita Sentry’s proprietary core technology enables a unique approach that takes into account the vascular tone to compute the value of BP, instead of simply estimating it from the measure of the blood flow. By detecting the diameter of arteries and arterioles with an accuracy of 0.5 μm over a measurement range, BP24 is the unique wearable intended for highly accurate -golden-standard comparable- BP monitoring. Therefore, not only it can be used by patients with hypertension, but in the future it will be used in patients undergoing surgeries – and the company’s efforts are directed towards that objective. Vita Sentry’s technology is enabling: being vasodilation and vasoconstriction in a number of physiological processes, knowing the arteries and arteriole diameters will allow to measure the metabolic rate and the stress level of a person. While this is a long-term objective, going to the market with BP24 for self-monitoring of people with hypertension is the goal of the innovation project. During Phase 1 project the Company will assess the scale-up industrialization plan, the trials needed to demonstrate the validity of the proposed solution and will evaluate a sound go-tomarket strategy to ensure successful commercialization of the device.

Keywords: wearable,smartwatch,blood pressure,hypertension,cardiovascular disease,e health,monitor
Cosmological Dark Energy Condensate (CosmoDEC): A unified description of the Dark Universe (CosmoDEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

A staggering amount of observational evidence, ranging from the study of the distribution of matter at large scales to galactic rotation curves, suggests the existence of an exotic form of matter. This alleged new component, which accounts for around a quarter of the energy content of our universe, is usually referred to as dark matter. The existence of this dark sector was also strongly supported by the fact that the sole gravitational interaction sourced by ordinary visible matter largely fails to account for structure formation in the early universe. Furthermore, redshift measurements of Type Ia Supernovae have shown that the universe is expanding at an accelerating rate, hence supporting the need for an additional dark energy component in the present-day observable universe. Thus, our current understanding of fundamental physics, encoded in the Standard Model of Particle Physics and the theory of General Relativity (GR), seems to suggest that we can only account for roughly 5% of the matter content of the cosmos, while the rest of it remains almost uncharted territory. The corpuscular theory of gravity offers a way to describe gravity in the strong coupling regime according to which GR completes itself in the UV through the process of classicalization. This pictures allows one to conceive the current cosmic expansion as driven by a ''cosmological condensate'' of gravitons. Besides, if one adds some ''baryonic impurities'' (galaxies and clusters) to this ''cosmological condensate'', then Milgrom's Modified Newtonian Dynamics (MOND) naturally emerges, in the corpuscular framework, as the response of the condensate to the local presence of ordinary matter. The scope of the proposed research is to build on these premises by combining the general wisdom of effective field theories of gravity, focusing on its ultra-violet (UV) self-completion, and the idea that that the two dark components can interact and source one another.
EMpowering transatlantic PlatfOrms for advanced WirEless Research (EMPOWER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Germany,Greece,Norway,France,France,France,United Kingdom
Call: EU-US Collaboration for advanced wireless platforms (H2020-ICT-2018-2, 2018)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 1999120.0
EU funding (EUR): 1999120.0
Participants: 11
Project status: CLOSED

EMPOWER ambitions to accelerate the joint development between the EU and the US on advanced wireless platforms targeting the new connectivity frontiers beyond 5G. EMPOWER targets the creation of a joint EU-US advanced wireless ecosystem for (i) bridging the relevant EU-US Wireless communities and stakeholders, such as scientific researchers, platform engineers, standardization experts, regulators, and product incubators; and (ii) developing a strategic EU-US collaboration agenda and supporting its execution ahead of worldwide competition for beyond 5G connectivity standards. EMPOWER foresees twinning with the best researchers and practitioners involved in projects funded by USA, especially with entities participating in the PAWR programme (https://www.advancedwireless.org/). EMPOWER will provide instruments for inducing collaboration between ongoing and forthcoming 5G and beyond initiatives targeting at wireless networks experimentation on both ends of the Atlantic. Through the EMPOWER instruments we aim to create an efficient means for stimulating the circulation of ideas and people between European and similar American experimental wireless platform initiatives. We also aim at encouraging stronger collaboration between fundamental and experimental wireless researchers by making access to platform tools and data exchange simpler. EMPOWER instruments will also provide a wealth of information for global and regional standards and regulatory organizations (e.g. ITU-R, ETSI) and industry fora (e.g. NGMN). An important additional output of EMPOWER will be in the form of recommendations on technologies and experimentation methodologies for future wireless experimentation objectives. This will assist in providing coordination between EU (Horizon Europe) and US NSF programmes for future individual and joint calls.

Keywords: wireless networking,advanced wireless platforms,us collaboration,networking community,experimentation and experimental research,nsf pawr
Physical Activities of Older Adults: Longitudinal Interdisciplinary Analysis (PAOLInA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The PAOLInA-project focuses on physical activities of older citizens of European countries. It begins with the analysis of the phenomenon “physical activities”, and their change in the course of the late and latest years of life. The goal is to show what is covered by the term “physical activities” (PAs), and to differentiate PAs into domains according to their purpose (e.g. sports in leisure time, PA for self-care, PA as form of transportation). The Experienced Researcher (ER) hypothesizes that the overall involvement of older adults in PA does not necessarily decline as the individuals are getting older, but that some types of activities may even increase or replace others. If these interdependencies are neglected in the measurement older adults may appear as more sedentary than they actually are. The ER will also examine the factors that influence the change of the PAs. She will look at the interplay between individual characteristics and the attributes of people’s living environments. As a result, patterns of PA promoting factors will be carved out. The research will be based on secondary analysis of various longitudinal data sets, such as the German Socioeconomic Panel (SOEP) and the Survey of Health and Retirement in Europe (SHARE). Multilevel modelling will be applied in the statistical analyses. Thus, the PAOLInA-project is innovative in several respects: It will differentiate the PAs, which – according to the state of the existing research – has rarely been the case. It will reveal the long-term developments in older adults’ engagement and involvement in PAs. It will match individual characteristics with environmental and regional indicators. The ER will introduce her perspective of health psychology into an institute that does not have this specialization yet. She will benefit from the excellent methodological expertise of her prospective supervisor, additional training and support from the partners, and get access to a European network of collaborators.
Transcriptional Adaptation and Genetic Compensation (TAaGC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Organisms utilize several mechanisms to compensate for the damaging consequences of genetic perturbations. One such mechanism is the newly identified process of transcriptional adaptation (TA): in this process, certain deleterious mutations trigger the transcriptional modulation of so-called adapting genes. In some cases, e.g., when one of the upregulated genes is functionally redundant with the mutated gene, TA leads to functional compensation. Notably, unlike other modes of compensation, TA is not triggered by the loss of protein function. This unexpected observation has prompted studies into the machinery of TA and the contexts in which it functions. Following our discovery of TA (Rossi et al., 2015), we have shown that in zebrafish embryos and mouse cell lines, mutant mRNA degradation triggers this process (El-Brolosy et al., 2019). We also observed TA in C. elegans and found that small RNA biogenesis, in addition to mutant mRNA degradation, is required for this process (Serobyan et al., 2020). While these and other studies have documented the importance of TA and its occurrence across phylogenetically distant organisms, several key questions remain in terms of how TA arises and how prevalent it is. In this proposal, we aim to investigate the mechanisms that underlie TA, including 1) what determines which genes are targeted as adapting genes during TA, and 2) how the expression of these genes is modulated during TA. These studies will be carried out in zebrafish, C. elegans, mice, and multiple mouse and human cell lines, capitalizing on the genetic and biochemical approaches available in each model system, while simultaneously allowing us to analyze the conservation of the mechanisms underlying TA. In addition, we will investigate the relevance of TA in human health and disease. Ultimately, this work will further our understanding of the mechanisms that modulate genetic and phenotypic robustness in humans.

Keywords: transcriptional adaptation,genetic compensation,robustness,zebrafish,c elegans,mouse,human,small rnas,mutant mrna degradation
Personalized intelligent platform enabling interaction with digital services to individuals with profound and multiple learning disabilities (INSENSION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Slovenia,Poland
Call: Interfaces for accessibility (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-10-31
Duration (months): 46.0
Total project cost (EUR): 2255875.0
EU funding (EUR): 2255875.0
Participants: 6
Project status: CLOSED

The INSENSION project will create an ICT platform that enables persons with profound and multiple learning disabilities (PMLD) to use digital applications and services that can enhance the quality of their lives, increase their ability to self-determination and enrich their lives. The target end users of the proposed solution are capable of using only nonconventional, nonsymbolic means of interaction with their environment. Therefore, the platform aims to provide technological means for seamless, and adaptable recognition of a range of highly individual nonsymbolic behavioral signals of people with PMLD to detect behavioral patterns happening in the context of specific situations. These patterns are translated into the affective ‘intents’ of the end user (their approval or disapproval to the given situation) and allow to communicate them to assistive services. This way an individual with PMLD gains a possibility to seamlessly influence their living environment, through new means of communication with other people, changing conditions of their environment or use new types of assistive digital applications. The project employs recent advances in a range of ICT disciplines equipping the proposed assistive ICT platform with natural behavior recognition mechanisms based on gesture, facial expression and vocalization recognition technologies. This is complemented by novel techniques of artificial intelligence and state-of-the-art Internet of Things models. The research and development of the project is conducted within the inclusive design paradigm, with individual with PMLD and their caregivers directly participating in the R+D process throughout the whole duration of the project. This process links a highly interdisciplinary team of experts of ICT specialists and researchers and practitioners of disability studies and care, with due participation of an assistive technology industry representatives.

Keywords: profound and multiple learning disabilities
Mediterranean Gypsies. A forgotten history beyond diaspora, nomadism, marginality in three Western Mediterranean areas of the Spanish Crown (Andalusia, Sicily, Sardinia, 16th- early 18th century) (MediterraneanGypsies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-10
End date: 2021-01-10
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Thanks to the collaboration in Leeds between an expert in Gypsy and Italian history (the fellow, Dr Aresu, who will restart his academic career) and a scholar in modern Spanish history (the supervisor, Dr Alonso), MediterraneanGypsies aims at a rethinking of the way the history of Gypsy people has been framed to date. It proposes an innovative interpretative paradigm, which it applies to a specific study case: Gypsy mobility in three Western-Mediterranean areas of the Spanish Crown (Andalusia, Sicily, Sardinia) in the modern era (16th, 17th and early 18th century). Traditional reconstructions, based mainly on institutional repressive documents (e.g. acts of the Inquisition), have privileged a reductive vision of the Gypsies as a diasporic, nomadic, marginal minority that was relentlessly persecuted. By building on his previous researches, Dr Aresu will analyse instead a broad range of primary sources, mostly unpublished - from custom records to notarial deeds and parish funds -, that he will collect via an extensive archival search in Madrid, Sevilla, Palermo, Cagliari and in the Romani Collection of the University of Leeds. With an interdisciplinary approach that intersects transnational history, micro-history and historical anthropology, the project will investigate the economic and social relations of Gypsy groups both among themselves and with the other residents, scrutinise their articulated relationships with the local and state institutions, and insert their mobility strategies within the broader circulation processes existing throughout the Mediterranean as a whole. A special focus will be on the role of women, in order to challenge the mono-dimensional image of the Gypsy fortune-teller and enchantress. Beyond its scholarly value, the project will produce and disseminate alternative narratives on Gyspy history, which can potentially counter the worrying anty-gypsyist discourses that still have currency in parts of contemporary European society.

Keywords: gypsies,mediterranean sea,spanish empire,andalusia,sicily,sardinia,mobility,diaspora,nomadism,marginality
The Molecular Basis of Somatic Nuclear Reprogramming (ReachingCompleteness)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The direct conversion approach and the generation of induced pluripotent stem cells (iPSCs) provide an invaluable resource of cells for disease modelling, drug screening, and patient-specific cell-based therapy. However, the directly converted cells are not stable, and the vast majority of iPSCs exhibit poor developmental potential as measured by stringent pluripotency tests. This suggests that the prevailing method of reprogramming is not ideal and leads to aberrant/incomplete conversion. To improve the quality of the converted cells, efforts should be focused on uncovering the molecular mechanisms that characterize the nuclear reprogramming process. There are two critical hurdles that hinder the progress of deciphering the elements that dictate successful reprogramming: (1) The ability to detect and capture solely the rare cells that eventually will be converted and (2) to monitor the transcriptional profile of cells at the single-cell level. Single-cell technology is in its infancy and many of the methods used today are characterized by high noise to signal ratio. In this grant proposal we intend to overcome these limitations by (1) establishing a complex fluorescent knock-in reporter system using the CRISPR/Cas9 method to capture the early rare reprogrammable cells and by (2) employing several cutting-edge single-cell technologies, RNA-Seq, Fluidigm BioMark and single-molecule mRNA-FISH, to segregate the real signal from the noise. To identify common and more global elements that facilitate nuclear reprogramming at large, we will trace in parallel, reprogrammable cells from two different somatic cell conversion models that reach high degree of nuclear reprogramming, and analyse their transcriptome using sophisticated bioinformatic tools. This study will provide a general overview of the changes that occur during the conversion of various cell types and will uncover the basic features that are essential to reach safe and complete conversion.

Keywords: trophoblast stem cells,induced pluripotent stem cells,reprogramming,direct conversion approach,single cell technology