Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING (NAMDIATREAM)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Ireland,Spain,Austria,Switzerland,Germany,France,France,Germany,France,Germany,France,France,Spain,Italy,France,Germany,France,United Kingdom,United Kingdom,Ireland
Call:  (FP7-NMP-2009-LARGE-3, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 16519663.2
EU funding (EUR): 11999205.0
Participants: 23
Project status: CLOSED

NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highly specific “lab-on-a-bead”, “lab-on-a-chip” and “lab-on-a-wire” nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver •Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment •Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell •Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires •Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. •OECD-compliant nanomaterials with improved stability, signal strength and biocompatibility Direct lead users of the results will be the diagnostic and medical imaging device companies involved in the consortium, clinical and academic partners

Keywords: nanomedicine,diagnostics,imaging,lab-on-a-bead,lab-on-a-chip,nanoparticles,biomarkers,shg,plasmag
Developing a leading-edge European Micro- and nanoelectronics cluster for energy efficient ICT (SILICON EUROPE)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Transnational cooperation between regional research-driven clusters
Action type: Coordination and support actions
Countries involved: France,Netherlands,Belgium,Germany,Netherlands,Netherlands,Belgium
Call:  (FP7-REGIONS-2012-2013-1, 2012)
Start date: 2012-10-01
End date: 2015-10-31
Duration (months): 37.0
Total project cost (EUR): 3049682.96
EU funding (EUR): 2771334.0
Participants: 11
Project status: CLOSED

Four of the leading European micro- and nanoelectronics regions are joining their research, development and production expertise to form the transnational, research-driven cluster “Silicon Europe”. Involved in this national “triple-helix” consortia are the following high-potential mature clusters: the German Silicon Saxony, centred in Dresden, the Dutch High Tech NL, centred around Eindhoven in the South Eastern part of the Netherlands, France’s Minalogic, centred in Grenoble, and Belgium’s DSP Valley, centred at Leuven. The Silicon Europe partners are linked by a common goal: to make Europe the world’s leading centre for energy efficient electronics – Silicon Europe – The Leaders for Energy Efficient ICT Electronics The involved clusters in total have nearly 800 members , most of them (more than 75%) are SMEs, and count for more than 150.000 jobs (covering thereby more than 60% of the respective jobs in Europe) . They combine highly relevant research actors such as imec, CEA-Leti and Fraunhofer as well as large companies such as Philips, NXP, Globalfoundries, Infineon, STMicroelectronics and Thales. All involved clusters cover the full triple helix. Within Silicon Europe, following an in-depth analysis, joint action plans will be developed for concerted research in the field including the development of regional smart specialisation strategies and a internationalisation strategy for the involved clusters. Silicon Europe has as its ambition to place Europe in a leading position in research and development for the key enabling technology of Micro- and Nanoelectronics by using the full potential of synergy and complementarities of the existing high-potential clusters in France, Germany, Belgium and the Netherlands and potentially other European clusters. The extension of the collaboration between the clusters towards a Joint Action Plan on local as well as on European level and its implementation will have a major impact on the competiveness of the entire sector.

Keywords: cluster cooperation,micro- and nanoelectronics,energy-efficiency,ict,semiconductor,dresden,grenoble,leuven,eindhoven,minalogic,silicon saxony,dsp valley,point-one
European North Sea Energy Alliance (ENSEA)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Transnational cooperation between regional research-driven clusters
Action type: Coordination and support actions
Countries involved: Norway,United Kingdom,Netherlands,Germany,United Kingdom
Call:  (FP7-REGIONS-2012-2013-1, 2012)
Start date: 2012-10-01
End date: 2015-12-31
Duration (months): 39.0
Total project cost (EUR): 3193829.6
EU funding (EUR): 2889692.0
Participants: 8
Project status: CLOSED

The European North Sea Energy Alliance (ENSEA) aims to increase the competitiveness of research-driven energy clusters through better coordination and exploitation of research. A key driver for cluster policy definition in ENSEA will be the adoption of an energy system approach by all four partner regions, focusing on how to handle the rising share of renewable energy production in the existing energy system. ENSEA regions capitalise on the current successful collaboration between the Northern Netherlands and North Western Germany (Hansa Energy Corridor) extending this approach to Scotland and Norway. ENSEA brings together 4 high growth potential research-driven energy clusters (>20 research institutes and > 90 billion Euro investments within the regions) combines Europe’s largest players within the field of production and distribution of natural gas and electricity (Energy Valley), fossil gas and oil exploration (Scottish region), supplier of clean energy (Rogaland) and renewables (Ems-Achse). The interaction between these activities create a highly advanced energy system. Increased transnational coordination of efficient knowledge development is necessary to prevent inefficient resource use and speed up the implementation of a resource efficient Europe. By facilitating highly directed knowledge development ENSEA aims to: 1) align extensive research and education programs; 2) build a transnational network of large and small businesses; 3) measure and monitor our network developments through social network interaction; 4) build upon existing partnerships such as the Sichuan region in China to open up new markets. The balancing function of the ENSEA regions combined is not only a crucial precondition for sufficient and affordable sustainable energy, it will prevent inefficient use of public and private funding while contributing to the development of a competitive and innovative energy economy throughout the North Sea region.

Keywords: energy system integration,formalized transnational collaboration,north sea region,renewables,triple helix establishment,efficient knowledge development
Making Persons with Disabilities Full Citizens - New Knowledge for an Inclusive and Sustainable European Social Model (DISCIT)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Major trends in society and their implications
Action type: Collaborative project
Countries involved: Norway,Germany,Czechia,Ireland,Italy,Sweden,Switzerland,United Kingdom,Belgium,Serbia
Call:  (FP7-SSH-2012-2, 2012)
Start date: 2013-02-01
End date: 2016-01-31
Duration (months): 36.0
Total project cost (EUR): 3057647.2
EU funding (EUR): 2463304.0
Participants: 11
Project status: CLOSED

DISCIT aims to produce new knowledge enabling Member States, affiliated European countries and the European Union to achieve full and effective participation of persons with disabilities in society and the economy. In investigating the social and political conditions for making such participation a reality, the project adopts a multifaceted understanding of Active Citizenship. Adopting a multilevel and institutional perspective, DISCIT examines how different types of policies (social benefits, social services and social regulation instruments) can be mutually supportive in enhancing Active Citizenship for persons with disabilities. Using the UN Convention on the Rights of Persons with Disabilities (CRPD) as a framework of reference, DISCIT identifies more effective ways to remove and prevent physical, attitudinal, social and organisational barriers to Active Citizenship and participation on an equal basis with others, in a context of rapid social and economic change and evolving conceptions of disability across European societies. DISCIT synthesises policy lessons from a strategic sample of European states: ‘Liberal’ (Ireland, United Kingdom), ‘Conservative’ (Germany, Italy), ‘Social Democratic’ (Norway, Sweden) and ‘Post-Communist’ (Czech Republic, Serbia) regimes. DISCIT involves consortium members from all these countries in addition to Switzerland and Belgium. DISCIT’s results provide new insight into how the European Union can support Member States and affiliated European countries in working towards the realization of the rights of persons with disabilities as expressed in the Fundamental Rights under the EC Treaty and the CRPD. By clarifying the possibilities for a strengthened synergy between policies at diverse levels of governance, DISCIT contributes to knowledge for realizing the ambitions of the EU Disability Strategy 2010-2020 and the Europe 2020 Strategy for Smart, Sustainable and Inclusive Growth. DISCIT has a duration of 36 months; is coordinated by Norwegian Social Research (NOVA); the consortium members are universities, research institutes and two civil society organisations (EDF and MDRI-S). The consortium is supported by a Scientific Advisory Committee with distinguished members mainly from countries not covered by the consortium members, a European Stakeholder Committee and eight National Stakeholder Committees. www.discit.eu

Keywords: active citizenship,disability,european social model,multi-level governance,multi-policy system,multi-stakeholders,life-course,changing social inequalities,ageing demographics,innovation
All Rights Reserved? Barriers towards EUropean CITIZENship. (BEUCITIZEN)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: The Citizen in the European Union
Action type: Collaborative project
Countries involved: Netherlands,Belgium,Croatia,Czechia,Estonia,Denmark,Denmark,France,Germany,Germany,Greece,Hungary,Ireland,Israel,Italy,Italy,Poland,Spain,Spain,Sweden,Switzerland,Türkiye,United Kingdom,United Kingdom,Germany
Call:  (FP7-SSH-2012-1, 2012)
Start date: 2013-05-01
End date: 2017-04-30
Duration (months): 48.0
Total project cost (EUR): 8429336.6
EU funding (EUR): 6490312.0
Participants: 26
Project status: CLOSED

The European Court of Justice expects European citizenship to become the fundamental status of nationals of the Member States. It ‘lies at the heart of the European integration process’. The treaties, legislation, and case law have given Europeans an increasing number of rights. Yet the European Commission complains that these remain underused. Therefore, it has included in FP7 a call for a large-scale IP, identifying and analyzing ‘barriers’ to exercising such European citizenship rights. Utrecht University is initiating a response to this call. In its project proposal it identifies research questions and several categories of potential hindrances as answers to some of them: contradictions between different rights, ‘multilevel’ rights, and differences in priorities Member States accord these rights; differences in political, administrative, and legal institutions; financial restraints; lack of sufficient solidarity; administrative and bureaucratic hurdles; language problems; and other practical barriers to claiming and exercising rights - and related duties. Furthermore we distinguish citizenship rights by the types of rights - economic, social, political, and civil - and by the ascribed characteristics of the subjects of these rights: male and female, young and old, native and immigrant. We believe multidisciplinarity will help in identifying and analyzing barriers to the exercise of European citizenship. We can learn from other times and places; therefore we add a historical and comparative dimension to the analysis. And we aim to combine insights from the historical, legal, and social sciences. Overall we want to investigate the options for a multilayered citizenship true to the EU's motto 'In Varietate Concordia'. The research questions and theoretically identified barriers will be investigated in 12 different work packages, each containing specific research objectives, tasks, roles of the participants, and deliverables

Keywords: mutilayered citizenship,multidimensional citizenship,multidisciplinarity,legal rights and social practices,citizenship claims
Conference WIRE 2012. Delivering the Innovation Union at Regional Level. (WIRE 2012)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Regions of Knowledge
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2012-02-10
End date: 2013-02-09
Duration (months): 12.0
Total project cost (EUR): 263470.0
EU funding (EUR): 249085.0
Participants: 1
Project status: CLOSED

The WIRE 2012 project aims at organising the conference “Week of Innovative Regions in Europe”. The general concept of the WIRE2012 conference is to present both grand challenges and main barriers concerning the development of innovativeness in regions as well as to elaborate the recommendations for European and regional innovation policy makers. The Conference shall be focused on the issue of how to implement the Innovation Union at the Regional level. The leitmotiv of the WIRE2012 - delivering the Innovation Union at Regional Level – will be discussed within three main thematic pillars - the sections of the event: • Smart regions in the Horizon 2020 will investigate the issues of regions, regional smart specialization, cities as innovation hubs, regional infrastructure and regional innovation ecosystems in particular within the Horizon 2020; • Stairway to Excellence will focus on future of regional dimension of research and innovation, synergy between the Horizon 2020 and the Cohesion Policy, smart specialization of convergence regions and Centres of Excellence; • Networking for ERA at the Regional Level will discuss the European Territorial Cooperation, networks of clusters, European Groupings of Territorial Cooperation, networks of research infrastructure and Multiregional Knowledge Partnerships (e.g. Danube, Baltic).

Keywords: regional development innovation union regional policy stairway to excellent smart regions networking of era
Recognition of bacteria by NK cells (BACNK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Israel
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-03-01
End date: 2018-02-28
Duration (months): 60.0
Total project cost (EUR): 2499800.0
EU funding (EUR): 2499800.0
Participants: 1
Project status: CLOSED

NK cells that are well known by their ability to recognize and eliminate virus infected and tumor cells were also implicated in the defence against bacteria. However, the recognition of bacteria by NK cells is only poorly understood. we do not know how bacteria are recognized and the functional consequences of such recognition are also weakly understood. In the current proposal we aimed at determining the “NK cell receptor-bacterial interactome”. We will examine the hypothesis that NK inhibitory and activating receptors are directly involved in bacterial recognition. This ground breaking hypothesis is based on our preliminary results in which we show that several NK cell receptors directly recognize various bacterial strains as well as on a few other publications. We will generate various mice knockouts for NCR1 (a major NK killer receptor) and determine their microbiota to understand the physiological function of NCR1 and whether certain bacterial strains affects its activity. We will use different human and mouse NK killer and inhibitory receptors fused to IgG1 to pull-down bacteria from saliva and fecal samples and then use 16S rRNA analysis and next generation sequencing to determine the nature of the bacteria species isolated. We will identify the bacterial ligands that are recognized by the relevant NK cell receptors, using bacterial random transposon insertion mutagenesis approach. We will end this research with functional assays. In the wake of the emerging threat of bacterial drug resistance and the involvement of bacteria in the pathogenesis of many different chronic diseases and in shaping the immune response, the completion of this study will open a new field of research; the direct recognition of bacteria by NK cell receptors.

Keywords: nk cell receptors,bacteria
The Hidden Frontier: Quantitative Exploration of Physical and Ecological Origins of Microbial Diversity in Soil (SOILLIFE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Switzerland
Call:  (ERC-2012-ADG_20120216, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 2196632.0
EU funding (EUR): 2196632.0
Participants: 1
Project status: CLOSED

By some accounts exploring the origins of soil microbial diversity represents a scientific frontier similar to that of space exploration in its scope, described by Curtis and Sloan (2004) as ”an immense and unexplored frontier in science of astronomical dimensions and of astonishing complexity”. The complexity is attributed to soil ecological heterogeneity reflecting interplay of spatio-temporal, physical, and nutritional variables delineating spheres of influence that define microbial habitats and function. Key to microbial life in soil is a flickering aqueous network that defines nutrient diffusional pathways and shapes microbial dispersion and interactions. We propose to develop an individual-based and spatially resolved modeling platform that explicitly considers soil pore structure and aqueous phase configuration and associated biophysical processes forming a virtual soil microcosm. The assembly of these complex ingredients into a computational platform will enable systematic hypotheses testing concerning central questions in microbial ecology that are neither addressed by present ecological theories nor emerge from standard continuum models. Specifically, the project will provide quantitative insights into effects of hydration extremes on survival strategies, the roles of space and diffusional heterogeneity, aspects of dispersion and trophic interactions, self-organization of consortia, and emergence of temporal niches in soil. The research will transform quantitative understanding of soil biophysical processes, a gap that presently limits coherent interpretation of the rapidly growing molecular-based estimates of soil biodiversity, and is essential for guiding future data collection. The research lies at the interface between environmental microbiology and soil physics cutting across disciplinary boundaries and addressing broad issues impacting soil and water quality, the functioning of global bio-geochemical cycles, and the fate of anthropogenic pollutants.

Keywords: soil microbial diversity,hydration,coexistence,dispersion,diffusion fields
Geometric analysis in the Euclidean space (ANGEOM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Spain
Call:  (ERC-2012-ADG_20120216, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 1105930.0
EU funding (EUR): 1105930.0
Participants: 1
Project status: CLOSED

We propose to study different questions in the area of the so called geometric analysis. Most of the topics we are interested in deal with the connection between the behavior of singular integrals and the geometry of sets and measures. The study of this connection has been shown to be extremely helpful in the solution of certain long standing problems in the last years, such as the solution of the Painlev\'e problem or the obtaining of the optimal distortion bounds for quasiconformal mappings by Astala. More specifically, we would like to study the relationship between the L^2 boundedness of singular integrals associated with Riesz and other related kernels, and rectifiability and other geometric notions. The so called David-Semmes problem is probably the main open problem in this area. Up to now, the techniques used to deal with this problem come from multiscale analysis and involve ideas from Littlewood-Paley theory and quantitative techniques of rectifiability. We propose to apply new ideas that combine variational arguments with other techniques which have connections with mass transportation. Further, we think that it is worth to explore in more detail the connection among mass transportation, singular integrals, and uniform rectifiability. We are also interested in the field of quasiconformal mappings. We plan to study a problem regarding the quasiconformal distortion of quasicircles. This problem consists in proving that the bounds obtained recently by S. Smirnov on the dimension of K-quasicircles are optimal. We want to apply techniques from quantitative geometric measure theory to deal with this question. Another question that we intend to explore lies in the interplay of harmonic analysis, geometric measure theory and partial differential equations. This concerns an old problem on the unique continuation of harmonic functions at the boundary open C^1 or Lipschitz domain. All the results known by now deal with smoother Dini domains.

Keywords: harmonic analysis,geometric measure theory,quasiconformal mappings,geometric function theory