Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Women Entrepreneurs for STEM (WE4STEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Austria,Egypt,Indonesia
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 606542.86
EU funding (EUR): 561200.0
Participants: 7
Project status: CLOSED

The objective of the project is to develop new and lasting international, interdisciplinary and intersectoral collaborations in the research field of entrepreneurial education. The scientific goal is to create an evidence-based outreach intervention that (1) identifies potential candidates for entrepreneurship from among European female graduates and postgraduates in STEM fields, (2) strengthens their entrepreneurial intention and (3) points them to digital entrepreneurial education based on their personal profile. Entrepreneurship drives economic growth, job creation and innovation. In the Entrepreneurship 2020 Action Plan, the European Commission outlines the importance of strengthening Europe’s entrepreneurial potential. However, despite a range of actions entrepreneurial intentions are low in more developed economies. This is especially true for women in STEM fields, and it is particularly true for female students. Although the underrepresentation of women entrepreneurs is determined by socio-cultural and economic factors, studies show that entrepreneurship education can have a positive influence on the development of entrepreneurial intention. However, little research has been conducted to design evidence-based interventions. It is the aim of the proposal to create an evidence-based intervention that identifies candidates for entrepreneurship from among European female graduates and postgraduates within STEM, strengthens their entrepreneurial intention and points them to digital entrepreneurial education. Using data analysis, machine learning tools and Educational Technology we contribute to improving the profile matching that connects female graduates and postgraduates within STEM to entrepreneurship and uses algorithms to match between learner profile and intervention. We believe the intervention can significantly contribute to improving European economic competitiveness, strengthening human capital, and promoting gender equality within STEM entrepreneurship.

Keywords: entrepreneurship women entrepreneurs character computing entrepreneurial education stem
Electrochemistry-enabled Reductive Alkyl Radical Generation from Alcohols (e-AlcToRad)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2026-07-31
Duration (months): 36.0
Total project cost (EUR): 265647.84
EU funding (EUR): 265647.84
Participants: 2
Project status: SIGNED

Transition metal-catalysed cross-coupling reactions are considered landmark achievements in organic synthesis; thus, a modern organic chemist’s toolbox is filled with methods building C(sp2)-C(sp2) bonds. However, the myriad of tetrahedral carbon atoms in organic molecules alongside the ever-growing interest in drug discovery and development to access the tree-dimensional chemical space has encouraged chemists to develop cross-couplings that involve C(sp3) atoms. Despite their ubiquitous nature, the most available sources of functionalised C(sp3) atoms, alcohols, are underutilised in cross-coupling reactions due to the difficulty associated with the C(sp3)-O cleavage step. Their mainstream adaptation for cross-coupling reactions would unlock a previously untapped chemical space by virtue of their structural diversity, stability, and convenience. Furthermore, shifting the focus from halides to more environmentally benign alcohols offers a green and sustainable future by minimising manufacturing costs and toxic waste. Therefore, the overarching goal of this proposed research programme is to devise new, generally applicable, and modular methodologies in organic chemistry to address the long-standing challenge of alkyl radical generation from alcohols; thus, making the C(sp3)-OH bond a mainstream radical cross-coupling handle. Using transition metal catalysis, downstream application of these radicals would construct C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-heteroatom bonds furnishing complex structures from ubiquitous precursors. In order to harness the potential of native alcohols, and to achieve the aims of this proposal, the outgoing phase of this fellowship would take place in Prof. Phil S. Baran’s laboratory at Scripps Research, La Jolla, USA. During the third, final year, the incoming phase would take place at Dr. Josep Cornella’s laboratory at Max-Planck-Institut, Mülheim an der Ruhr, Germany.

Keywords: radical chemistry,alcohol activation,electrosynthesis,transition metal catalysis
Reductive Coupling Reactions via Polar / Radical Crossover (POLARCROSS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

This fellowship project aims to establish a new suite of photocatalytic reductive coupling methodologies using feedstock starting materials that will allow the efficient synthesis of important value-added compounds. Key to this proposal is the design and development of a reductive photocatalytic system comprising a suitable organic reductant and a photocatalyst that upon photoexcitation becomes simultaneously strongly Brønsted acidic and strongly reducing. Under appropriate reaction conditions the novel photon-controlled acidity would catalyse alcohol dehydration and concomitant single electron transfer (SET) to the arising carbocation would generate the free-radical capable of undergoing a broad range of synthetically useful intermolecular and intramolecular carbon-carbon bond forming processes The chemistry is particularly suited for generating fully substituted carbon atoms in a process where only water is the by-product. Based on these results, a new strategy for the synthesis of bioactive complex (alkaloid) natural products will also be developed. We anticipate that further advancement of these findings will revolutionize the synthesis of complex bioactive molecules using feedstock starting materials, and more broadly influence the way chemists design and access such intricate motifs. The POLARCROSS fellowship offers a high-quality and cutting-edge research platform that will enhance the state-of-the-art in European Commission funded research and will complement Dr. Wang's existing skills set. This fellowship will serve as a catalyst for enhancing the competencies needed to realize his career aspiration of securing an academic position at a top-tier institution and embarking on an independent research journey. Furthermore, it will nurture him into a seasoned, versatile researcher equipped with the diverse skill set required for the advancement of science and the betterment of society.

Keywords: new methodology development,polar radical crossover,carbon carbon bond formation,natural product synthesis
Fast-track hybrid testing platform for the development of battery systems (FASTEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,North Macedonia,Spain,Portugal,Slovenia,United Kingdom,Germany,Italy,Finland
Call: Digitalisation of battery testing, from cell to system level, including lifetime assessment (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 4781008.71
EU funding (EUR): 4781008.71
Participants: 18
Project status: SIGNED

Current methods to evaluate Li-ion batteries safety, performance, reliability and lifetime represent a remarkable resource consumption for the overall battery R&D process. The time or number of tests required, the expensive equipment and a generalised trial-error approach are determining factors, together with a lack of understanding of the complex multi-scale and multi-physics phenomena in the battery system. Besides, testing facilities are operated locally, meaning that data management is handled directly in the facility, and that experimentation is done on one test bench. The FASTEST project aims develope and validate a fast-track testing platform able to deliver a strategy based on Design of Experiments (DoE) and robust testing results, combining multi-scale and multi-physics virtual and physical testing. This will enable an accelerated battery system R&D and more reliable, safer and long-lasting battery system designs. The project’s prototype of a fast-track hybrid testing platform aims for a new holistic and interconnected approach. From a global test facility perspective, additional services like smart DoE algorithms, virtualised benches, and DT data are incorporated into the daily facility operation to reach a new level of efficiency. During the project, FASTEST consortium aims to develop up to TRL 6 the platform and its components: the optimal DoE strategies according to three different use cases (automotive, stationary, and off-road); two different cell chemistries, 3b (NMC/Si-C) and 4 solid-state (oxide polymer electrolyte); the development of a complete set of physic-based and data-driven models able to substitute physical characterisation experiments; and the overarching Digital Twin architecture managing the information flows, and the TRL6 proven and integrated prototype of the hybrid testing platform.

Keywords: electrochemical battery,characterisation,virtualisation,li ion battery,solid state battery,digitalisation,modelling
Ancient Battles, New Weapons: Uncovering Germline Defense Innovations and Transposon Invasions in Caenorhabditis species (TEvsRNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 306206.74
EU funding (EUR): 214344.72
Participants: 1
Project status: SIGNED

The germline is the only immortal lineage in animals, making it a target for transposable elements (TEs) to perpetuate themselves at the host's expense. To counter these threats, animals utilize Piwi-interacting RNAs (piRNAs) to suppress TEs and maintain germline integrity. Despite the crucial role of piRNAs, the diversity of mechanisms organisms use to repress parasitic elements remains largely unexplored. To address this, I propose studying an emerging model system, the nematode Caenorhabditis plicata; one of the few Caenorhabditis species that lost the piRNA pathway. Notably, our preliminary results indicate that C. plicata employs novel small RNA (sRNA) classes to silence TEs. My first aim is to dissect the molecular basis of this sRNA pathway and elucidate its evolutionary origins. To do so, I will screen for the underlying molecular component controlling this pathway; firstly by targeting homologs of proteins involved in C. elegans sRNA silencing, and secondly, via EMS mutagenesis to identify mutations that suppress silencing of transgenic reporters. I will then investigate whether the novel sRNA populations are ancestral or a recent innovation by examining independent piRNA loss events across different Caenorhabditis species. Motivated by the natural loss of piRNAs and the widespread transfer of TEs between species, my second aim is to develop an experimental model to study foreign TE invasions in nematodes through heterologous insertions of TEs into mutant worms that are unable to defend against these elements. I will then examine the subsequent impact on genome architecture and explore whether they contribute to genome size expansion. This comprehensive approach will not only teach us how animals protect their germline but also deepen understanding of how biological novelty can arise from the ancient evolutionary arms race between invasive elements and silencing pathways.

Keywords: transposable elements,pirna pathway,invasive elements,genomics,silencing pathways,nematodes,caenorhabditis elegans,evolutionary biology,horizontal gene transfer
Health and Gender Health Inequalities: a longitudinal analysis using the Survey of Health Ageing and Retirement in Europe (SHARE) (HI-GEN-SHARE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 207266.88
EU funding (EUR): 207266.88
Participants: 1
Project status: CLOSED

Health inequalities are a major concern in all European countries, however, these disparities are still marked inside societies. The literature on health inequalities has focused mainly on single-country studies and with a limited time span such as early conditions or late life situation of individuals. However, a cross-country longitudinal approach is fundamental to tackle the origins and evolution of health inequalities and to understand the heterogeneity of these type of disparities with a geographical perspective. In this setting, the focus on gender health disparities has not been addressed exhaustively yet. The main approaches have proposed a biological ground under which male-female differentials in health outcomes occur; or a social approach where different health risks are associated based on the gender. However, the economic discipline can contribute to advance the understanding of gender health inequalities by exploiting individuals and administrative data, along with novel quantitative econometric analysis; to investigate whether gender health disparities take place based on the health services provision. This project aim to address these fundamental issues by taking advantage of the Survey of Health and Retirement in Europe (SHARE), in a cross-countries longitudinal set up. Administrative data about the healthcare supply from EUROSTAT will be linked to understand gender health disparities. The focus of this project is critical, even more in the context of the current COVID-19 Pandemic, which have put the societal welfare under strain. The outcomes of the project will advance the comprehension of health inequalities, help in reducing gender health disparities and support policy reforms in the healthcare systems, all over Europe. This project will provide me with the necessary competences and enforce my econometric skills and management proficiency, to establish myself as an independent research leader in the field of health economics in Europe.

Keywords: health inequalities,gender health inequalities,healthcare systems,share,longitudinal data,causal inference
Mechanisims of nuclear self-assembly (Organelloids)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499974.0
EU funding (EUR): 1499974.0
Participants: 1
Project status: SIGNED

Shape and function of the vertebrate nucleus depend on the choreographed interplay between lipids, proteins, and DNA to form the nuclear envelope. Even small molecular changes, such as point mutations in the proteins of the nuclear envelope (the lamina) cause detrimental human diseases including premature aging, cancer, and heart disease. To date, a clear, mechanistically compelling explanation for the dynamic coupling of lipids, proteins, and DNA to safeguard nuclear shape and function is still missing. We here propose to build minimal, synthetic nuclei (‘Organelloids’) bottom-up as a tool to study the self-assembly of a functional nucleus. We recently discovered the conserved molecular machinery that ensures the assembly of the nuclear envelope in open vertebrate mitosis. Our data point to uncharacterized fundamental mechanisms that couple the fusion of lipid-membrane sheets into a continues nuclear membrane to the formation of the lamina, and the organization of chromatin in the same chain of events. In this proposal, we will leverage our recent advances in reconstitution to build ‘Organelloids’ to recapitulate shape and function of the membrane-lamina-chromatin confluence. Using these nuclear Organelloids we will resolve the nuclear assembly process in high resolution by applying integrated structural biology and determine the unknown biophysical principles that drive the self-organization of individual molecules into one functional organelle. Our strategy will reveal the unknown hierarchical relationship between lipids, proteins, and DNA and produce detailed mechanistic models for the formation and coupling of functional subdomains that are commonly observed in the nuclear membrane, the lamina and chromatin. With cell models and top-down approaches we ultimately aim to define the fundamental principles that govern nuclear biogenesis with implications for health and disease.

Keywords: lipid protein dna self organisation organelle structure and function,biophysics
InceNtivising fuTurE foRest eCosystem sErvices anD incomes in Europe (INTERCEDE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Denmark,Netherlands,Finland,Belgium,Spain,Italy,Germany,Romania,Bulgaria
Call: Capturing market trends and societal perceptions for tailor-made forest services (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 5999675.0
EU funding (EUR): 5999675.0
Participants: 13
Project status: SIGNED

Forests are crucial for climate mitigation, biodiversity protection, water flow regulation, recreational, cultural and health services – and many other forest ecosystem services (FES). Yet, as our key challenge, Europe’s forests at present critically undershoot their potential to deliver FES. Climate change will affect future FES supply. Societal demand for FES will be complex, and highly dynamic. Some FES economic values are ill explored. Facing these challenges, INTERCEDE will help to better match future FES supply and demand from Europe’s forests. First, we will project theory-informed yet evidence-based scenarios for future FES supply and demand. Second, as recognized in the EU Forest Strategy, Market-Based Instruments (MBI) can be key in improving tailored incentives and incomes for forest owners to manage their forest for socially optimal FES provision. MBI can thus help aligning FES supply with multidimensional demand. We will comprehensively map and evaluate Europe’s current MBI landscape, adding new rigorous impact evaluations of Payments for Environmental Services (PES) schemes, while also assessing the EU’s Rural Development Programme (RDP) investments from a PES angle. From this, we will develop effective, adaptable and scalable MBI policies. We can only achieve this by systematically connecting research to policy and practice, creating our multi-actor aligned Transdisciplinary Forum as key interface. Our consortium brings together small and medium-sized enterprises assisting forest owners in FES management practices, organisations representing landowners and environmental interests, and researchers who excel in modelling and valuing FES, in the economics of instrument design, and in governance and policy analysis. The consortium will mid-way in the project set up an Accelerator Service for (new or pre-existing) PES and MBI schemes, piloting new designs and MBI business models to boost the development, outcomes and impacts of targeted interventions.

Keywords: forest policy,valuation of non marketed goods,economics,incentives
oUtcome iNDicators to mEasuRe Progress on climate resIlieNce (UNDERPIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: France,Italy,Spain,Austria,Netherlands,Germany
Call: Develop and refine outcome indicators to measure progress on climate resilience at national, regional and local levels, including knowledge and feedback developed from the Mission (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 2998937.5
EU funding (EUR): 2998937.5
Participants: 9
Project status: SIGNED

UNDERPIN addresses critical gaps in monitoring, evaluation, and learning (MEL) for climate adaptation across Europe. It will design, develop, and validate an outcome-oriented framework that enhances existing frameworks for assessing climate resilience. This framework will include operationalized process and outcome indicators to track adaptation progress at local, regional, and national levels. A major challenge is the lack of standardized indicators capturing the effectiveness of adaptation efforts. Existing frameworks often focus on processes but fail to assess long-term resilience outcomes. UNDERPIN aims to bridge this gap by developing indicators that evaluate both short-term results and long-term impacts, helping stakeholders assess how well adaptation actions reduce vulnerabilities and enhance resilience. To achieve this, UNDERPIN will review existing climate adaptation and disaster risk reduction (DRR) indicators and integrate novel data sources, including Earth observation and citizen science. The project will involve stakeholders in three pilot regions to co-create and refine the framework, ensuring practical relevance and adaptability. A user-friendly dashboard with AI and machine learning tools will provide real-time analysis at the EU and regional level, helping decision-makers track progress, identify gaps, and make data-driven decisions. A citizen science and just climate resilience lens is used throughout the different activities of UNDERPIN. By aligning with EU and global reporting standards, such as the EU Adaptation Strategy and the UNFCCC, UNDERPIN will harmonize climate adaptation monitoring across governance levels, fostering a coordinated approach to resilience-building in Europe.

Keywords: indicators,climate adaptation,eu adaptation mission,earth observation data,citizen science,ai,europe