Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
vEnturing oN heTERodoped Polycyclic aRomatIc hydrocarbonS to develop smart labEls (ENTERPRISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

The scientific goal of ENTERPRISE is to develop and apply multifunctional chromogenic heteroatom-doped polycyclic aromatic hydrocarbons to produce materials that can empower current packaging technology and elevate electrochromic displays to the age of interactivity. These smart labels can thus provide information to people in an unequivocal and yet appealing way. We plan to produce materials that, through a selective reaction with O2, irreversibly retain an oxidising event and successively communicate it as an irreversible colour change under a human input. To achieve it, we envisage to prepare hybrid O-doped chromogenic polycyclic aromatic hydrocarbons that, in the presence of O2 and light, will act as a photosensitiser producing singlet O2. The reactive O2 will interact with the chromogenic material itself to give endoperoxide species that, under an external stimulus, yield radical species initiating an irreversible coloured polymerisation. Integration of this material into a prototype electrochromic display will result in a label that operates irreversibly after it has been exposed to O2 and reversibly when not exposed to O2. Considering that the leading cause of food-spoilage is related to aerobic oxidations, we expect our results to initiate a series of further technological advancements in the field of labels for smart packaging of food, opening the door to the first O2-sensitive, user-friendly, rapid, flexible and printable label. Through this fellowship, the applicant will enhance her creative and innovative research potential and her multidisciplinary competence of organic materials, with the final goal to become a prime researcher at the interface between fundamental and applied research. This will be made possible by the coordinated effort of a focused and highly motivated young supervising team composed of a leading academic institution and a vibrant enterprise.

Keywords: organic materials,polycyclic aromatic hydrocarbons
Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance (THERMOGUIDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-16
End date: 2021-07-15
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

Keywords: thermotherapy,hyperthermia,medical device,breast cancer,primary breast cancer,chemotherapy
Leveraging online services to enhance the efficiency and transparency of recycling and trading of metal throughout the EU. (Schrott24)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2022-02-28
Duration (months): 30.0
Total project cost (EUR): 1686403.75
EU funding (EUR): 1180482.63
Participants: 1
Project status: CLOSED

The production of primary raw materials, such as metals, requires widespread and large-scale mining. This involves heavy processes and chemicals with harsh labour conditions, substantial transport and pollution emissions. Waste from extractive processes is one of the largest waste streams in the EU (727 million tonnes p.a.), with certain fractions containing high concentrations of toxic substances including heavy metals. The mining and processing of virgin materials is a leading cause of deforestation and requires huge amounts of energy and water. Furthermore, these processes account for 7% of global energy consumption and contribute substantially to carbon emissions. The widespread use of secondary (recycled) raw materials is crucial to addressing this global challenge. The European metal recycling industry has the potential to be a major contributor to a sustainable future for the EU. However, it is outdated, offline, and inefficient, leading to low recycling rates even for valuable commodities. The Schrott24 Platform is an intelligent online marketplace that digitises and automates large parts of the industry for scrap metal and recycled metals. It dynamically matches buyers and sellers to optimise outcomes for both parties, aligning the European scrap trading market with the digital single market. We use advanced pricing and matching algorithms, matching the seller of a certain metal scrap, with a certain logistics need, with the most efficient recycling solution. This can be a local scrap yard for a small electrician with 500kg of copper cable waste, or a specialized aluminium smelter that is in need of a specific alloy in the yard of a scrap dealer unknown to them. With the integration of transport service providers, they are not only matched, but we can facilitate the whole process, to ensure the fulfilment of the clients’ needs. Schrott24 is disrupting the industry, allowing it to deliver a sustainable, circular economy for raw materials in the EU.

Keywords: recycling,scrap metal,platform,digital innovation,waste,environment,energy reduction,emissions,reduction,sustainable,raw materials,resources
Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus (ThymusTolerance)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2220000.0
EU funding (EUR): 2220000.0
Participants: 1
Project status: CLOSED

Central tolerance is shaped in the thymus, a primary lymphoid organ, where immature T lymphocytes are “educated” into mature cells, capable of recognizing foreign antigens, while tolerating the body’s own components. This process is driven mainly by two separate lineages of thymic epithelial cells (TECs), the cortical (cTEC) and the medullary (mTEC). While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T (Treg) cells. Crucial to the key role of mTECs in the screening of self-reactive T cell clones, is their unique capacity to promiscuously express and present almost all self-antigens, including thousands of tissue-specific antigen (TSA) genes. Strikingly, the expression of most of this TSA repertoire in mTECs is regulated by a single transcriptional regulator called Aire. Indeed, Aire deficiency in mice and human patients results to multi-organ autoimmunity. Although there has been dramatic progress in our understanding of how thymic epithelial cells shape and govern the establishment of adaptive immunity and of immunological self-tolerance, there are still several outstanding questions with no comprehensive answers. Therefore, in the research proposed herein, we wish to provide more comprehensive answers to these still elusive, but very fundamental questions. Specifically we will aim at: 1.) Delineation of molecular mechanisms controlling TEC development and thymus organogenesis; 2.) Delineation of molecular mechanisms underlying promiscuous gene expression in the thymus; 3.) Identification and characterization of molecular determinants responsible for the breakdown of thymus-dependent self-tolerance. To this end, we will build upon our recently published data, as well as unpublished preliminary data and utilize several state-of-the-art and interdisciplinary approaches, which have become an integral part of our lab’s toolbox.

Keywords: aire,thymic epithelial cells,thymus,aps 1,central tolerance,autoimmunity
Single-Molecule Studies on Condensin (SMSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy. How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes. Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis. However, the molecular mechanism on how conformational changes of condensin compact DNA is still unknown. Here, the applicant Dr. Je-Kyung Ryu proposes to use two orthogonal single-molecule approaches, “high-speed AFM (HS AFM)” and “single-molecule fluorescent magnetic tweezers” to reveal the molecular mechanism of condensin. HS AFM imaging is a unique technique to record video-rate real-time images for entire structure of a protein in physiological condition with high spatiotemporal resolution (~1nm, ~50ms). In addition, using single-molecule fluorescence microscopy combined with magnetic tweezers, the applicant can understand how the cooperative binding of condensin to DNA correlate with DNA condensation. These two approaches will not only provide most important clues to understand the mechanism of condensin how DNA enters and exits the condensin ring and how condensin shapes chromosome but also include technical advances in single-molecule techniques. This work will be carried out in the laboratory of Prof. Cees Dekker, who is a world leader in HS AFM and single-molecule biophysics of DNA-protein interactions. The applicant’s experts in single-molecule biophysics, fluorescence microscopy, and biochemistry will make synergetic effects with the resources of the Dekker lab to collectively meet the interdisciplinary demands of the innovative effort.

Keywords: condensin,hs afm,single molecule fluorescence,magnetic tweezers,dna condensation
Multimodal hyperspectral system for imaging of biological tissues glycation (MultiBioScan)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-12
End date: 2022-02-11
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The ultimate goal of the MultiBioScan is to train a talented researcher through a research project focused on the development of novel tools for the early in vivo real-time assessment of the diabetes mellitus complications, including diabetic foot syndrome. This will be achieved using the latest methods of hyperspectral imaging, including the measurement of diffuse reflection, fluorescence, speckle patterns and polarization, as well as an advanced data mining approach. The Fellow will be trained in biomedical optics (biophotonics), a fast growing field of science and medical application. He will receive access to a unique training experience at the host – Aston University (UK), and at academic and industrial secondment partners: University of Oulu (Finland), University-Hospital of Padua (Italy), SPECIM, Spectral Imaging Ltd. (Finland). The MultiBioScan outputs will be relevant to the EU life sciences sector by offering new cost-efficient technologies for real-time in vivo diabetes mellitus complications screening. Given the huge and fast-growing market of medical diagnostic equipment, the project results have a good opportunity for successful commercialisation. The Fellow will use his present connections to optical equipment manufacturers in EU to develop commercialisation opportunities, and new connections will be established through this project. The project brings together a talented young Fellow with a strong biomedical science and engineering background, and an internationally growing group of researchers at Aston University with expertise in the area of developing laser-based photonic devices for biomedical research and clinical diagnostics.The Fellow will be further supported by medical and industrial expert co-hosts who will help train the Fellow in key skills and support the translational research process. The translational part of the project will primarily be aimed at adapting results of scientific studies to actual conditions of clinical practice.

Keywords: biomedical engineering,biophotonics,hyperspectral imaging,fluorescence spectroscopy,diffuse reflectance spectroscopy,laser speckle contrast imaging,polarisation
AQUAculture and Agriculture BIOmass side stream PROteins and bioactives for Feed, FITness and health promoting nutritional supplements (AQUABIOPROFIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Spain,Greece,Greece,Norway,Greece,Norway,Bulgaria,Sweden,Norway,France,Netherlands
Call: Proteins and other bioactive ingredients from side streams and residues (H2020-BBI-JTI-2017, 2017)
Start date: 2018-04-01
End date: 2022-12-31
Duration (months): 57.0
Total project cost (EUR): 4057391.99
EU funding (EUR): 3349527.0
Participants: 13
Project status: CLOSED

The AQUABIOPRO-FIT main objective is to promote efficient utilisation of European aquaculture, fisheries and agriculture side streams in feeds and nutritional supplement products promoting fitness and health. To this end, we will develop side stream biomass processing technologies to up-concentrate nutrients and bioactives maintaining product quality and minimising waste. The safety, bioactivity and acceptance of the developed ingredients and products will be documented through cell, animal, taste panel and intervention studies with humans, namely athletes and patient groups. Technical, marketing, economic and environmental studies will complement the documentation portfolio of the AQUABIOPRO-FIT concepts and products. The developed knowledge and principles will be further systematised in net-based training modules, which will follow the intellectual property rights of the developed methods and products. Information material will be created for educating the public and raise awareness of the importance of circular economy and promote acceptance for side stream bio-based products in end markets.

Keywords: aquaculture,fisheries,agriculture,nutrition,side streams,residues,valuable ingredients
Assessing, preserving and restoring man-microbes symbiosis (Homo.symbiosus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2491014.0
EU funding (EUR): 2491014.0
Participants: 2
Project status: SIGNED

The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbiome and host features with auto-aggravating crosstalk signals. The result is increased incidence of incurable immune-mediated diseases of modern societies that affect a third the human population on earth today and for which current therapeutics only address symptoms alleviation, rather than considering man as a holobiont. In this context and its resulting threat for the human species, I will carry out a project geared to open a new era of individualized preventive care and novel gut ecology-based therapeutic approaches. The project will assemble insights and contributions from theoretical to experimental ecology, quantitative and functional microbiomics, preclinical work, cohort studies and clinical trials, so as to: • Validate the concept of critical transition and alternative stable state as it applies to a shift from man-microbes symbiosis to disease-prone man-microbes dysbiosis • Assess the potential of diet alone to promote such a shift • Model the symbiosis-to-dysbiosis transitions and derive predictors of tipping points • Propose counter-measures that may allow to break vicious circles and restore a balanced, health-prone, man-microbes symbiosis by concomitantly acting upon microbiome and host features • Validate strategies to reinforce ecological robustness and restore man-microbes symbiosis Based on a paradigm shift, the proposed work will set the grounds for future personalized preventive nutrition and clinical management considering man as a true holobiont.

Keywords: intestinal ecology,host microbiota symbiosis,critical transition,dysbiosis,microbiotherapy
Deciphering the machinery involved in stability of the transcription factor HOXA9. (HOXA9 degradome)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-07
End date: 2020-09-05
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Transcription factors are often mutated or aberrantly expressed in cancer and drive carcinogenesis. HOXA9 is a master transcription factor that controls a network of genes critical for hematopoiesis. It shows increased expression levels in more than 50% of patients with acute myeloid leukemia (AML), and is strongly associated with poor clinical outcome. Since the initiation and progression of AML depend on elevated HOXA9 levels, it represents an attractive therapeutic target to combat this aggressive malignancy. However, transcription factors are often not amenable to direct pharmacologic inhibition. To overcome this limitation, an alternative strategy aiming at interference with the transcription factor-specific 'degradome' - the degradation machinery regulates HOXA9 stability. To this end, we aim to elucidate the HOXA9 degradome with the goal of identifying its druggable nodes. Specifically, we plan to (1) identify regulatory proteins involved in the degradation of HOXA9 by performing a FACS-based positive selection screen with a focused CRISPR/Cas9 library as perturbation tool, (2) validate candidate proteins involved in the control of HOXA9 stability, and (3) characterize hits suitable for pharmacologic targeting. For the most promising HOXA9 regulators, we will determine their specificity by assessing global changes of protein abundance by proteomics. The potential of employing hits for pharmaceutical targeting will be evaluated by integrating molecular information with clinical data. In summary, this project aims to establish novel strategies for the dissection of the transcription factor HOXA9 degradome by developing a flexible screening platform. Through this project, I will not only acquire new skills but also establish a scientific network, which is expected to intensify the collaboration between DKFZ and Harvard Medical School. Two years’ experience in USA followed by one year in Heidelberg will be undoubtedly a milestone in my career development.

Keywords: functional genomics,molecular biology,translational research,drug target discovery,cancer research