Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fundamental Limits of Quantum Mechanics and Physical Laws in a Non-deterministic World (FLQuant)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2223065.0
EU funding (EUR): 2223065.0
Participants: 1
Project status: SIGNED

Quantum mechanics is fundamentally different from all that came before in almost every aspect. But, as far as I can see now, there is one property that stands above all when we try to understand what quantum mechanics is all about: quantum mechanics is our first theory of Nature that is non-deterministic at a fundamental level. Long considered an unpleasant aspect, non-determinism is anything but: Non-determinism enables new freedoms. Phenomena that could not occur in deterministic theories because they would violate some basic laws of nature become possible in non-deterministic theories, under the cover of randomness. A famous example is nonlocality. In a deterministic world, if something acting in one place would instantaneously produce effects somewhere else, it would violate relativity; non-determinism allows it. As in recent years nonlocality/entanglement came to be viewed as one of the main aspects of nature, and as its existence implies non- determinism but not vice-versa, non-determinism itself was seen as secondary. But non-determinism allows many more freedoms. The vision of this project is to change the paradigm, and put non-determinism at the core. The aim is to go well beyond the insights gained from nonlocality and focus on the other freedoms. It will explore very recently discovered situations with indefinite causal order; situations in which the future can affect the past without leading to paradoxes; evolutions subjected to both initial and final conditions; implications for conservations laws, and thermodynamics, the hitherto ignored dynamic nonlocality, etc. – all fundamental aspects of nature in which non-determinism is the key. Finally, quantum mechanics may not be the ultimate theory of nature. The project aims to explore the full extent of the freedoms allowed by non-determinism in quantum mechanics as well as in arbitrary theories. By comparing what is possible in general to what is specifically quantum, I hope to better understand both.

Keywords: quantum mechanics,fundamental aspects,quantum information,time in quantum mechanics,non locality,conservation laws
Early Medieval Glosses And The Question Of Their Genesis: A Case Study On The Vienna Bede (GLOSS-VIBE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

The early medieval period is marked by constant interchange and multicultural relationships, and has significantly shaped Western intellectual history. During this time Irish scholars started to annotate texts, i.e. underlining, highlighting, glossing etc. – techniques that quickly spread across the European continent and are still used today. Gloss-ViBe will research the early medieval Celtic glossing tradition on the Venerable Bede’s De Temporum Ratione. Its main research question is: “Are vernacular glosses original compositions or translations from original Latin glosses?” The present project will investigate the Celtic and Latin glosses found in the manuscript Vienna, Österreichische Nationalbibliothek, Codex 15298 (olim Suppl. 2698) from different angles including methodology from the digital humanities, philology, linguistics and translational studies. Since there is a lack of comprehensive editions of early medieval glossed manuscripts, this study is a pioneering and challenging task. One of its main deliverables will be the first such comprehensive digital documentary edition. It will include the primary text and all the glosses and annotations found in the Vienna Bede. Because of the fragile nature of the manuscript and recent advances in digital humanities in conjecture with a simultaneously arising interest on how to annotate (digital) documents caused by the recent shift from paper to digital media, the proposed research is highly topical at this time. It offers insights into how information has been processed that can be directly applied to modern annotation systems. Additionally, researching the multicultural environment in which early medieval manuscripts were composed also has impact for understanding modern migration patterns, especially in a scholarly environment.

Keywords: digital editions,early medieval glosses,multilingualism,language contact
Enhanced real time services for an optimized multimodal mobility relying on cooperative networks and open data (TIMON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Spain,Slovenia,Belgium,Hungary,Netherlands,United Kingdom
Call: Cooperative ITS for safe, congestion-free and sustainable mobility (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-11-30
Duration (months): 42.0
Total project cost (EUR): 5605213.0
EU funding (EUR): 5605213.0
Participants: 13
Project status: CLOSED

Europe would be close to solving problems related to congestion, traffic safety and environmental challenges if people, vehicles, infrastructure and business were connected into one cooperative ecosystem combining integrated traffic and transport management with new elements of ubiquitous data collection and system self-management. The main objective is increasing the safety, sustainability, flexibility and efficiency of road transport systems by taking advantage of cooperative communication and by processing open data related to travel through a cooperative open web based platform and mobile application, developed with the purpose of delivering information and services to drivers, businesses and Vulnerable Road Users in real time. The operative objectives will be to: - Analyse stakeholder’s needs incorporating them in the specification of the transport services delivered by the platform; - Identify transport open data sources of information and harmonizing this data to be used as real-time information; - Define and implement and fully distributed global architecture to enable cooperative sensing in ITS; - Leverage the information gathered from vehicular communications, GNSS and open data by means of artificial intelligence techniques; - Develop hybrid networks, supporting 802.11p and mobile communications, which will allow assuring a stable communication channel between vehicles and VRU (usually bringing smartphone). - Empower drivers to deliver data to the platform by leveraging the information generated by their mobile phones exponentially increasing the information available on traffic status. - Implement ITS services arranged in the following main areas: driver assistance, vulnerable users and multimodal dynamic commuter, enhanced real time traffic information API and TIMON collaborative ecosystem; - Design two validation environments, a test bed site and another located in an (inter)urban area;

Keywords: vulnerable road users,802 11p,gnss,artificial intelligence,ghg reduction,crashes reduction,open platform,open data,services and applications,cooperative networks,c its
Exercise training in metastatic colorectal cancer patients – effects on tumor recurrence, physiological adaptations and disease progression. (POET-mCRC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2025-02-28
Duration (months): 36.0
Total project cost (EUR): 328968.0
EU funding (EUR): 328968.0
Participants: 1
Project status: SIGNED

Every year nearly 228,000 individuals die from colorectal cancer (CRC) in Europe, the second most common cancer in Europe. Around 30% of the CRC patients develop liver metastases and these are the main cause of death. Removal of liver metastatic tumors is the primary treatment method for CRC, however, 50-75% of the patients experience a relapse of the metastases within two years, rendering adjunct treatment strategies necessary for these patients. Preclinical work has demonstrated that exercise exerts anti-tumor effects as it is indeed able to inhibit tumor growth. Thus, exercise constitutes an excellent candidate as a complementary to the pharmacological treatment approach for CRC metastatic patients (mCRC). My primary aim is to investigate the effects of chronic exercise on tumor recurrence after liver metastasis removal. Secondary aims are to identify the “optimal dose” of exercise to obtain the largest beneficial effect and explore the changes on circulating tumor DNA (ctDNA) as a marker of disease progression. I hypothesize that exercise training will delay or ameliorate disease recurrence in mCRC patients. Patients will be randomized to 3 groups: control, group 1(300 min/week), group 2 (150 min/week) of combined aerobic and strength exercise training for 6 months. Study endpoints will be tumor recurrence, inflammation and immune markers, physiological adaptations and ctDNA changes. The outcomes will provide essential knowledge about how to optimize the guidelines for exercise prescription as part of the treatment plan for mCRC patients. The fellowship will be vital for my reintegration into academia and for me to evolve as a lead researcher. It also constitutes an ideal means of knowledge transfer between myself and the host organization as I will gain knowledge in the oncology area and advance my skills in molecular biology techniques while I convey my experience in dose-response methodology and the conduct of large-scale human exercise trials.

Keywords: colorectal cancer,liver metastasis,aerobic exercise,resistance exercise
Quick Sepsis Test (QUIST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Netherlands
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In QUIST, a protein will be validated as a biomarker for early detection and prognosis of sepsis in combination with several other surrogate sepsis biomarkers. Specific objective is: • To perform a feasibility study in order to gain better insight in the risks and potential hurdles for the validation study in Phase 2 and future exploitation of the project’s results. This study will contain technical, commercial and economical issues. Expected outcomes: • A solid businessplan as a result of the feasibility study. This businessplan will contain information that is currently incomplete or lacking about the market (identification of potential customers, competitors, distributors and competing technologies), regulations and industrial partners for the commercial development of a POCT for sepsis. Based on this information, also a strategy will be defined for IP management. • A research plan for the validation study, addressing technical hurdles defined in the feasibility study.

Keywords: sepsis,point of care,clinical diagnostics,mass spectrometry,immunoassay
Seismogenic COmpression in southern Italy? – High-resolution topography (Lidar) and mOrphotectonic analySis to test the active nature of the Southern ApenninE Outer Thrust Front (COLOSSEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

Over the past decade (1999-2009), earthquakes proved to be the deadliest of all European disasters. Italy is one of the most seismically active countries in Europe and, Southern Italy, is recognized as the most seismically active sector of the peninsula. The sector is traversed by the Apennine fold-and-thrust belt which is seismogenic, along the Outer Front, in northern-central Italy and in Sicily. On the contrary, it is considered often inactive in southern Italy. Nevertheless, historical seismicity reports several destructive earthquakes and geological-geomorphological indications of recent deformation have been recently pointed out. The geological setting contrasts the recognition of the seismogenic sources since the Apennine Outer Front is buried under Plio-Quaternary foredeep successions. It is urgent to develop new approaches to investigate the active deformation in this sector. This research aims to detect evidence of Late Quaternary active compressional faulting along the Southern Apennine Outer Front. The peculiar geological setting of the sector necessarily requires a multidisciplinary approach. The research plan envisages the integration of HRT (high resolution topography) data analysis, morphotectonic analysis in GIS/Matlab environments, geochronologic dating and classical methodologies of analysis belonging the seismotectonics. Airborne lidar topographic data are able to capture fault offsets and landscape properties recording the complexity and sensitivity of deformation. The drainage pattern analysis and morphometric indices computed using GIS (Geographic Information System) and Matlab programming language are suitable for evaluating the effects of active tectonics on the topography or morphological features. These novel approaches are exploding worldwide. Exploiting them in order to investigate the active deformation represents an excellent chance to improve the knowledge on the southern Apennines seismotectonic setting.

Keywords: active tectonics,earthquake hazards,lidar,geomorphic metrics,tectonic geomorphology,southern,apennines,italy
Dynamically Reconfigurable Optical-Wireless Backhaul/Fronthaul with Cognitive Control Plane for Small Cells and Cloud-RANs (5G-XHaul)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Germany,Spain,Germany,Greece,Greece,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2018-06-30
Duration (months): 36.0
Total project cost (EUR): 7233887.5
EU funding (EUR): 7233887.5
Participants: 13
Project status: CLOSED

Small Cells, Cloud-Radio Access Networks (C-RAN), Software Defined Networks (SDN) and Network Function Virtualization (NVF) are key enablers to address the demand for broadband connectivity with low cost and flexible implementations. Small Cells, in conjunction with C-RAN, SDN, NVF pose very stringent requirements on the transport network. Here flexible wireless solutions are required for dynamic backhaul and fronthaul architectures alongside very high capacity optical interconnects. However, there is no consensus on how both technologies can be most efficiently combined. 5G-XHaul proposes a converged optical and wireless network solution able to flexibly connect Small Cells to the core network. Exploiting user mobility, our solution allows the dynamic allocation of network resources to predicted and actual hotspots. To support these novel concepts, we will develop: 1) Dynamically programmable, high capacity, low latency, point-to-multipoint mm-Wave transceivers, cooperating with sub-6-GHz systems; 2) A Time Shared Optical Network offering elastic and fine granular bandwidth allocation, cooperating with advanced passive optical networks; 3) A software-defined cognitive control plane, able to forecast traffic demand in time and space, and the ability to reconfigure network components. The well balanced 5G-XHaul consortium of industrial and research partners with unique expertise and skills across the constituent domains of communication systems and networks will create impact through: a) Developing novel converged optical/wireless architectures and network management algorithms for mobile scenarios; b) Introduce advanced mm-Wave and optical transceivers and control functions; c) Support the development of international standards through technical and techno-economic contributions. 5G-XHaul technologies will be integrated in a city-wide testbed in Bristol (UK). This will uniquely support the evaluation of novel optical and wireless elements and end-to-end performance.

Keywords: c ran,network management,backhaul,fronthaul,mm wave,wdm pon,localization,beamsteering,mimo
DEVELOPMENT OF OMEGA-3 NANODELIVERY SYSTEMS USING ELECTROSPINNING PROCESSING (ELECTRONANOMEGA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-24
End date: 2017-08-23
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Functional foods containing omega-3 lipids, which have approved health claims by EFSA, have resulted in one of the fastest-growing food product categories in Europe. However, to successfully develop foods enriched with omega-3 PUFA, lipid oxidation of these highly unsaturated fatty acids must be prevented in order to avoid both the loss of nutritional value and the formation of unpleasant off-flavors. Omega-3 PUFA can be added to foods as neat oils or as a “delivery system” such as microencapsulated oil powders and oil-in-water emulsions. Nevertheless, delivery of omega-3 lipids in the form of emulsions reduces the oxidative stability of omega-3 PUFA in some products. Furthermore, microencapsulates are less suitable for liquid or semi-liquid foods than emulsified omega-3 oils due to handling/mixing issues. Therefore, the development of alternative omega-3 PUFA delivery systems, which are easy to disperse and which will lead to improved oxidative stability of omega-3 enriched food products, is urgently required. One of the more promising delivery systems can be functional nano-microstructures obtained by electrospinning technology, which is possible to up-scale. In light of the above, the aim of this research project is to develop advanced omega-3 delivery systems such as electrospun nano-microstructures. To this end, the specific objectives are: 1) Development of physically and oxidatively stable nano-microstructures with omega-3 PUFA and natural antioxidants using electrospinning processing. 2) Production of food enriched with the nano-microstructures having appropriate structural-functional properties and being oxidatively stable. The success of the research proposed will lead to an important advance in the protection of omega-3 PUFA against oxidation when incorporated into food. Thus, the knowledge generated by this study has the potential to being exploited by companies devoted to the production of functional foods containing omega-3 lipids.

Keywords: food technology,omega 3 fortification,nano microstructures,electrospinning processing,oxidative stability,physical structure,technological properties,antioxidants evaluation
Proteasome-Mediated Gene Expression in Plant Immunity (IMMUNE-EXPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1499960.0
EU funding (EUR): 1499960.0
Participants: 1
Project status: CLOSED

Plants are continuously exposed to a wide variety of pathogenic attackers that cause major crop losses to agriculture worldwide. Unlike vertebrates that use specialized immune cells to detect non-self, each individual plant cell is thought to be capable of launching an effective immune response. Plant immune responses are largely orchestrated by the immune hormone, salicylic acid (SA), which accumulates upon infection and establishes both local and broad-spectrum systemic immunity. SA induces the reprogramming of thousands of genes to prioritize immune responses over normal cellular growth functions. Consequently, commercial SA mimics have been developed and applied as crop protection agents worldwide. Nonetheless, how SA reprograms the transcriptome remains poorly understood yet is critical for the design of improved crop protection strategies that avoid plant growth and yield penalties. SA-induced transcription reprogramming is largely mediated by NPR1, a master coactivator of gene expression. We recently reported that direct perception of SA by a Cullin3-RING ubiquitin ligase (CRL3) in the nucleus regulates the transcriptional activity of NPR1 by targeting it for degradation via the ubiquitin proteasome system (UPS). Our latest data suggest that ubiquitination by CRL3 and other ubiquitin chain modifying enzymes may be processive and establishes a transcriptional timer for NPR1 activity. This proposal aims to understand the flexibility and necessity of this transcriptional ubiquitin timer in meeting cellular demands for dynamic gene expression during SA-mediated plant immune responses. Moreover, we will uncover the full substrate ranges of SA-induced ubiquitin ligases and their post-translational regulation to precisely chart the intimate roles the UPS plays in coordinating plant immune gene expression. Importantly, these findings will provide novel chemical and genetic targets that can be harnessed in future crop improvement strategies.

Keywords: salicylic acid,plant immunity,gene expression,ubiquitin,proteasome,redox