Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pharmacological and gene therapy targeting of NMNAT2 for neuroprotection in glaucoma (TARGET-NMNAT2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2261875.0
EU funding (EUR): 2261875.0
Participants: 1
Project status: SIGNED

The goal of this ERC Advanced Grant is to develop clinically translatable neuroprotective strategies for glaucoma by focusing on NAD metabolism. NMNAT2 is a neuron-specific NAD-generating enzyme and is the upstream enzyme that coordinates axon degeneration. The Williams lab is expert in taking basic biological findings in glaucoma to the clinic, and we will leverage our expertise in this space to develop novel clinically translatable therapeutic interventions for glaucoma based on NMNAT2 biology. In Program 1 my team will further our on-going drug development program developing novel compounds targeting NMNAT2 by: (1) Continuing refining medicinal chemistry to develop an oral and injectable formulation, (2) Confirming NMNAT2 engagement via autoradiography and assessing BBB permeability and distribution via PET radiopharmacology using fluorine-18 radio ligands of these compounds, (3) Assessing the neuroprotective potential of these compounds in proof-of-concept animal models of glaucoma. In Program 2 my team will target neuroprotection and axon regeneration to develop a comprehensive, titratable, single dose treatment for glaucoma via gene therapy by: (1) Combining a regenerative gene therapy (phosphomimetic Protrudin) with neuroprotective treatments (nicotinamide therapy, novel NMNAT2 compounds, NMNAT2 gene therapy), (2) Exploiting the E. coli DHFR and human FKBP destabilising domains to develop a gene therapy product which is rapid, titratable, and switchable (i.e. ON/OFF) and test this in the context of glaucoma. This ERC Advanced Grant will capitalize on my recent findings that targeting NAD can prevent degeneration in animal models and restore vision glaucoma patients and develop crucial in vivo data transitioning this program from TRL 3 to TRL 4. By the end of this funding, we expect to be in a position to perform our regulatory toxicology on our lead drug and gene therapy candidates and file for our IND in preparation for a Phase I clinical trial.

Keywords: novel pharmacology,gene therapy,glaucoma,retina,optic nerve,neuroprotection,neuroregeneration,nad
OLIGOFEED (OLIGOFEED_EU)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Pollinators are vital for global food production, with 85% of cultivated plant species and 40% of human diets depending on them. However, honey bee mortality has reached an alarming rate of 36% annually in Europe, contributing to pollination shortages affecting €22B worth of European crops. Oligofeed, a deep-tech startup spun off from a CNRS research laboratory, develops scientifically validated and health-enhancing micronutrients for animals. Its breakthrough molybdenum-based compound improves pollinator health and significantly reduces bee mortality. This patented solution is the result of 10 years of rigorous academic research, validated through over 1,500 field tests conducted with beekeepers and a multidisciplinary team of researchers across Europe and the United States. With its woman-led team of engineers and PhDs from five nationalities, Oligofeed aims to expand its product application to other animal species, essential for a sustainable food supply. The company pursues its long-term vision of becoming a global leader in functional food ingredients for animals.

Keywords: beekeeping,pollinators,chemistry,feed
Development and clinical evaluation of an end-to-end Heart Failure management solution powered by predictive AI (SignalHF)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 3554799.29
EU funding (EUR): 2488359.5
Participants: 1
Project status: SIGNED

Heart failure is a serious chronic medical condition that impairs the heart’s ability to effectively pump blood. Globally, it has a prevalence of 64 million people. Heart failure patients often have to be hospitalised to manage symptoms exacerbation. These hospitalisations are preventable with data-based insights and tailored therapies. But no holistic data platform for heart failure patients exists today. Implicity is set to change this situation with its suite of data-driven insights for managing heart failure. Implicity already provides a heart failure remote monitoring platform with symptoms-based decompensation detection features. In this project, we are developing a second module that focuses on AI-based prediction of heart failure events based on cardiac implantable electronic devices’ data, combined with an end-to-end software suite managing alerts, treatments, patient engagement and workflow optimisation, enabling better care and decreasing the hospitalisation burden.

Keywords: remote monitoring,ceid,heart failure,digital health
Dating rEcent climaTE Changes To fOrecast the futuRe (DETECTOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Greece,Spain,Cyprus,United States,Argentina
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 1614651.43
EU funding (EUR): 1367730.0
Participants: 12
Project status: SIGNED

Climate change and human history are closely linked. Paleoclimate studies are essential for improving climate models, particularly for the 60–12 ka period, characterized by glacial conditions and rapid millennial-scale climatic fluctuations. Investigating these oscillations is crucial for assessing modern global warming and its impact on extreme weather events and sea level rise. Conversely, the millennial-scale climate shifts after 12 ka drove mass migrations and economic transformations, leaving significant archaeological evidence. Paleoclimate studies and archaeology share methodologies like stratigraphic event definition and absolute dating, which are based mainly on 14C (up to 50 ka for organic materials) and luminescence techniques (up to 1 My for quartz and k-feldspar-rich samples). This study focuses on niche environments like islands and desert regions. The former preserve strong evidence of climate change and human activity, particularly in the Mediterranean, while the latter are considered modern analogues of past glacial arid conditions. Key sites include Sardinia, Crete, Cyprus, Balearic, Canaries islands and deserts in California, Texas and Argentina. DETECTOR builds on the IN-TIME project (IN-SITU INSTRUMENT FOR MARS AND EARTH DATING APPLICATIONS, G.A. 823934), which developed and validated a portable luminescence dating prototype (compared to lab analyses) through Alma Sistemi S.r.l. and the Luminescence Laboratory of the University of Sassari, Italy. Proposed studies will include field campaigns using updated portable instruments for in situ absolute dating. Measurements will be cross-verified with laboratory analyses to assess the instrument’s functionality, operational reliability, and performance, paving the way for a novel scientific instrumentation product. DETECTOR unite the expertise of partners from Italy, Spain, Cyprus, Greece, USA & Argentina.

Keywords: paleo climate study,luminescence,scientific instrumentation,field campaigns
Rewiring gene regulatory circuits to enhance central nervous system repair (EnhanceRegen)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The mammalian central nervous system (CNS) is the epitome of complex cellular architecture. Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower vertebrates. Regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury. These programs are under the control of dedicated regeneration enhancer elements, which grant adult cells transcriptional access to developmental genes. Neural stem cells in the mammalian CNS lack the gene regulatory circuits that dictate when and where to activate the expression of developmental genes for regeneration. Consequently, most of the cells lost to injury are never replaced. This proposal aims to rewire mammalian gene expression circuits to endow neural stem cells with the capacity to activate regenerative responses after injury. First, building on innovative technologies, some of which that I developed, we will identify injury-responsive enhancer elements in the mouse spinal cord with single cell and spatiotemporal resolution. Then, using machine learning, we will decode the rules of injury-sensing DNA elements to design synthetic injury-responsive enhancers for precise gene expression control in neural stem cells. Finally, we will use synthetic enhancers in therapeutically relevant gene delivery systems to rewire gene circuits in order to promote the recruitment resident stem cells for cell replacement through the reactivation of developmental genes that would otherwise remain silent. The proposed research will uncover basic principles of gene regulation after CNS injury and open new avenues for the design of smart gene therapies for regenerative medicine using synthetic regeneration enhancers.

Keywords: spinal cord mouse single cell genomics atac seq machine learning enhancers gene therapy reprogramming
Electron pairs without superconductivity (PairNoise)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1970986.0
EU funding (EUR): 1970986.0
Participants: 2
Project status: SIGNED

My aim with this proposal is to develop an electron pair microscope that can locally detect electron pairs without superconductivity, and to leverage this information to gain unprecedented understanding into quantum materials. The electronic properties of most materials, including metals and insulators, are underpinned by single electrons. Superconductors are a notable exception: here, the charge carriers are electron pairs. It has been proposed, in order to explain quantum materials’ mysterious and potentially useful properties, that electron pairs exist without superconductivity and underpin the properties of materials that are not superconducting. Indeed, tantalizing signatures of electron pairs have been reported in high-temperature and disordered superconductors above their transition temperature Tc. However, experimental evidence of such electron pairing is highly disputed and controversial, because there exists currently no experimental probe to locally distinguish electron pairs without superconductivity from single electrons. With PairNoise, I will develop and build a radically new electron pair microscope – based on a unique proof-of-concept instrument developed in my group – that can unambiguously detect electron pairs with atomic resolution. It combines scanning tunnelling microscopy (STM), microfabrication, and shot-noise spectroscopy. With the electron pair microscope, I will determine the nature of the state above Tc in the most interesting superconductors, conclusively determine whether the pseudogap is due to pairing, and find what limits superconductivity at even higher temperatures in quantum materials. My track record of developing first-of-its-kind STM instruments, and their successful utilization for scientific progress, perfectly positions me to make PairNoise a success and to open up a new research field with further applications in the detection of fractional charges, Majorana modes, and dynamical processes.

Keywords: scanning tunneling microscopy,high temperature superconductivity,disordered superconductors,topological superconductors,shot noise
State-dependent cloud phase feedbacks: enhancing understanding and assessing global effects (STEP-CHANGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2249666.0
EU funding (EUR): 2249666.0
Participants: 1
Project status: SIGNED

The ways in which clouds change with global warming remain elusive, as are the associated cloud-climate feedbacks that govern most of the spread in climate sensitivity simulated by current Earth System Models. This uncertainty in turn limits society's ability to take necessary action to avoid dangerous climate change. Despite considerable research progress in recent decades, additional complexities have been uncovered that further add to the uncertainty. For example, the understanding that many cloud-climate feedbacks change with time, due to their dependence on warming levels or patterns, is relatively recent. Cloud thermodynamic phase changes are the root cause of some of this state-dependence, and new research has revealed that these feedbacks could shift Earth's climate into a state that is more sensitive to greenhouse gas forcing than at present. Understanding and quantifying this state-dependence is therefore critically important, but such progress will require deep understanding of processes on a range of scales, from the microphysics that control cloud phase to large-scale impacts on climate. Furthermore, it has become evident that different cloud-climate feedback regimes are governed by different processes with their own unique state dependence that must be investigated separately. Therefore, the overall objective of STEP-CHANGE is to understand and quantify feedbacks associated with cloud phase changes, including their state-dependence, for three distinct cloud regimes in the following regions: the Arctic, the Tropical deep convective region, and the Southern Hemisphere storm tracks. This will be achieved through a bold and innovative research strategy which includes aircraft measurements, lab experiments, space-borne remote sensing, and a hierarchy of numerical model simulations. STEP-CHANGE builds on recent discoveries and innovations within the PIs research group, and is motivated by key knowledge gaps identified in recent IPCC assessment reports.

Keywords: clouds,precipitation,radiation,feedbacks,sensitivity
Efficient bio-production of next generation dyes for sustainable fashion (NextGen Dyes)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 2782697.5
EU funding (EUR): 1947888.0
Participants: 1
Project status: CLOSED

We are using biotechnology to address three global problems, sustainability, pollution, waste management. We produce eco-friendly, high-performance textile dyes from microorganisms through an efficient bio-production process. Our production is based on the use of our proprietary Synthetic Genomics platform, i.e. computational and genomic tools to engineer bacteria that produce colors from biomass waste streams. Our technologies provide solutions for the problems facing the textile industry, as our bio-produced dyes have the same dyeing performance as synthetic dyes but are cleaner to produce (independent from oil and toxic chemicals), safer to wear and are ready to be used by manufacturers. We will sell our flagship product, indigo blue, to dyeing houses/fabric manufacturers, full range of colors in following years. Achieving 50% market share at one of our large denim targets would be enough to meet 2025 business plan. We will reach €24M revenues with gross margin of 67% in 2026.

Keywords: valorization,aniline free,textile dyes,environmental protection,computational engineering,bioproducts,circular economy,corporate social responsibility,industrial bioengineering,engineering and technology
Autoforestation Mode: ON (Forest Maker)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 3570820.0
EU funding (EUR): 2499574.0
Participants: 1
Project status: CLOSED

At the current deforestation rate, it is estimated that there will be no forests left in between 100 to 200 years. As such, restoring woodlands has become a priority for nations but remains a massive challenge worldwide. Destruction is easy but forest restoration has inherent problems of scale, speed, efficiency, and cost. The modest results of massive reforestation projects show that the current state-of-the-art solutions cannot get the job done fast enough. Forestry is significantly behind, compared to other sectors, in digitalization, precision and efficiency. Forest Maker is a new-generation integrated automated planter platform - an all-in-one solution that performs the entire planting and data collection process without stopping, guided by software for the creation of a digital twin of forest for precise and easy management.

Keywords: precision forestry,survival rate,carbon dioxide absorption,silviculture,reforestation,forestation,service innovation,environmental and green technologies,automation and control systems,automation,engineering and technology
Smart Space Exploration Navigation (SENAV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Slovakia
Call: Space science and exploration technologies (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2022-12-01
End date: 2026-03-31
Duration (months): 40.0
Total project cost (EUR): 1438620.75
EU funding (EUR): 1438620.75
Participants: 4
Project status: SIGNED

Upcoming space exploration missions envisage precise and safe landing on planetary bodies as well as navigating orbiters, landers, space drones, and robots. Such missions will be performed at various distances from Earth, reaching from the vicinity of Earth and Moon out to several astronomical units for targets like Mars, asteroids or the icy moons of Jupiter and Saturn. A reliable execution of the operations mentioned above can only be achieved by implementing spacecraft autonomous operation and utilising the target body as a navigation reference. This brings a novel requirement for the incorporation of a higher-than-before grade of knowledge about the target, based on a-priori data and on measurements collected during the mission. Examples are globally geo-referenced features originating from mapping missions or the 3D structure of the landing area measured by the spacecraft in the final phase of a landing. This introduces the need for significantly improved on-board processing capabilities and smart algorithms for a wide range of space exploration missions with differentiated demands. Thus, SENAV aims to enable breakthroughs in technologies and scientific instrumentation for space science and exploration missions including those described in the Global Exploration Roadmap, with strong focus on optical navigation for orbiters, landers, drones, and robots with respect to fully autonomous navigation even for unknown environments. In order to enable these missions, SENAV will start (at TRL2-3) to develop and advance smart algorithms, optimized software solutions and miniaturized HW modules, all to be validated through analogous test in laboratory environment aiming to achieve TRL4+ for all HW and SW technologies. Consequent optimization of the payload data processing system accompanied by use of COTS components, as well as the miniaturization of high-performance hardware for integration into small space platforms, will contribute to the desired technological breakthroughs.

Keywords: optical navigation,landers,drones,robots,smart algorithms,ai,miniaturisation,high performance payload processing,crater navigation,adaptive robot drone vision concept