Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generative Pre-Training on MEDical event streams in Intensive Care (GPT-MEDIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1491267.5
EU funding (EUR): 1491267.0
Participants: 1
Project status: SIGNED

Background: Artificial intelligence (AI) holds great promise for improving patient care, but challenges related to data irregularity and complexity have hindered its translation into clinical practice. Modelling rich longitudinal electronic health records (EHRs) such as those found in intensive care units (ICUs) remains especially difficult, as they represent a complex interplay between the patient’s health and clinical decisions made in response. Objectives: We aim to develop a robust AI framework for flexible prediction of any outcome in the ICU and beyond. We will pioneer a class of generative pre-trained models optimised for complex EHR data (Objective 1). Our approach will be rigorously benchmarked across outcomes and hospitals (Objective 2) on a secure, federated infrastructure that ensures data privacy (Objective 3). Methods: Our approach treats EHR data as a stream of clinical events in continuous time and uses generative pre-training to learn both the likely time and the content of the next event. From generated sequences of future events, we will derive explainable predictions for any clinical outcome, including those not encountered before (zero-shot learning). Our approach will be powered by the largest set of harmonised multicentre ICU data to date, covering up to 1 million patients with 33 billion clinical events. We will refine existing methods in federated learning to allow for secure decentralised training of our models at scale. Innovation & Impact: Our work will introduce a novel paradigm for AI-based clinical risk prediction, setting the stage for a new era of flexible, general-purpose AI in medicine. Our unprecedented multicentre benchmarks will provide an urgently needed baseline for meaningful innovations in the field, while our federated approach will facilitate secure model building across institutions and borders.

Keywords: intensive care medicine reproducibility
RISE. Transfeminist resistance against heteroactivism and the antigender movement in stateless nations (RISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

Transfeminist resistance is critically under-investigated yet increasingly required in an era marked by a strong manifestation of heteroactivism and antigender mobilisations, often co-opted by far-right populisms to advocate for a nativist national identity. Stateless nations (groups with a distinct cultural, linguistic, and historical identity, without recognition as a sovereign state) are an ideal context to investigate how transfeminist resistance enables new insights into the intersection of legislation, lived experiences, and spatial struggles across scales. In the last decade, heteroactivism and antigender mobilisations have grown. Despite Europe’s strides in recognizing sexual/gender rights, studies reveal persistent state-based sexism and homophobia. In the stateless nations of Sardinia and Corsica, heteroactivist and antigender discourses are resisted by local transfeminist groups which see them as tools used to justify internal colonialism, turning these regions into sacrifice zones for military, energy, and carceral exploitation. RISE is based on two observations: (1) transfeminist resistance against the threats posed by heteroactivist and antigender mobilisation to inclusive societies is underexplored; (2) stateless nations where heteroactivist and antigender discourses on national identity and gender equality are contested remain overlooked. RISE will be the first project to examine transfeminist resistance to heteroactivism and antigender mobilisations in stateless nations to develop an intersectional understanding of gender equality in relation to national identity. I will bridge my experience as a transfeminist activist with theoretical reflection collaborating with Prof Browne, the geographer who defined the field of heteroactivism and antigender. Cited in 8000 works, she holds major influence across social sciences. With her and the UCD network engaged in related projects, I will complete RISE, contributing to future more inclusive EU societies.

Keywords: queer geographies trans geographies transfeminist activism feminist geographies collaborative research heteroactivism
Chip scaLE terAheRtz dual-comb system (CLEAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2026-04-01
End date: 2027-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

‘Clear’ aims to increase the technology readiness level of the state-of-the-art miniaturized frequency comb (FC) and harmonic frequency comb (HFC) quantum cascade lasers (QCLs), operating at terahertz (THz) frequencies, devised under the ERC Consolidator grant ‘SPRINT’, and develop a portable dual-comb sensing/imaging demonstrator apt to the translation of this technology to industrial end-users. The project aims to provide a compact, low-cost, small in production volume, size, weight and power consumption, dual-comb spectrometer (DCS) which provides short-term precision and long-term stability, superb signal-to-noise ratios, large spectral resolution, mW optical power/mode, and >1.3THz spectral coverage, employing the not-invasive broadband THz-frequency light of metrological FC sources without the need of neither complex moving parts nor gratings to separate optical frequencies and spread the optical spectrum. Both optical paths can easily be implemented on photonic chips, significantly reducing the design complexity and with excellent compensation for external perturbations, ensuring fast acquisition rates. The envisioned DCS performance far exceeds those of commercial time-domain or asynchronous optical sampling spectroscopy systems. Key objectives are: i) developing a compact, portable and accessible THz DCS; ii) validating its core technology with commercial end-users and at exhibitions; iii) evaluating opportunities by identifying new end-user applications, with a systematic market, IPR and regulatory compliance study. By the end of this programme, I plan to identify a solid exploitation route by directly collaborating with THz instrument producers and with targeted commercial end-users. Seeking new exploitation opportunities, ‘Clear’ prospects new directions and long-term impacts on many interdisciplinary fields crossing engineering, chemistry, biology, medicine, cultural heritage, quantum and optical communications.
Waste as Valuable Elements for Europe (WAVEE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Portugal,Croatia,Argentina,Germany,Spain,Greece,France
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 1230312.86
EU funding (EUR): 1082160.0
Participants: 12
Project status: SIGNED

WAVEE, Waste As Valuable Elements for Europe, aims at valorise skills and know-how coming from academic and industrial scientists operating in the field of waste treatment and material science by the development of cutting-edge and low impact recovery methods for critical raw materials, CRMs from spent Li-ion batteries. The adoption of microwave radiation and mechanochemical approaches, in combination with mild organic/metal-organic compounds to replace conventional pyrometallurgy and strong and hazardous acids will provide a leap forward safer and greener recovery. The developed protocols will be scaled-up to pre-industrial level, to assess the overall efficiency of the innovative recycling processes and the quality of recovered RMs. Lastly, recovered materials will be tested in brand-new devices, such as batteries, catalysts, sensors and nanoelectronics. The outcomes of the project WAVE are relevant in key sectors for EU economy and for EU citizens, tackling the challenge of sourcing rare elements and properly dealing with waste valorisation and circular economy. This will result in improved efficiency and sustainability of the whole industrial chain of battery recycling, while ensuring a solid and reliable source of key RMs within EU. WAVEE Action pursue its main objectives through an intersectoral secondment plan, training activities, workshops and seminars for academic, SME and public audience. The consortium created for the project WAVEE represents a solid combination of internationally-recognised academic organisations possessing a wide experience on protocols related to the synthesis and treatment of materials for energy applications and advanced characterizations that is benchmarked by track record in both research publications and implemented projects.

Keywords: battery recycling,critical raw materials,metals recovery,process scaling up
miRNA regulation of developmental sodium channel isoform transition and its implications for Dravet syndrome (miRSodium)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Netherlands,Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 3
Project status: CLOSED

Dravet syndrome (DS) is a rare epileptic encephalopathy affecting ~1:20000 children, who suffer from infantile seizures and lifelong deficits in cognitive, motor, behavioural, and social skills. DS can cause premature mortality with up to 21% of patients not reaching adulthood. Despite the known genetic origin – 80% of patients carry a mutation in the SCN1A gene encoding the alpha1 subunit of the sodium voltage gated channel – there is no cure for this disease. The symptoms of DS start at ~ six months of age, shortly after the transition from the developmental Nav1.3 (SCN3A gene) to the postnatal Nav1.1 (SCN1A) channel isoform carrying the mutation. The mechanism of this transition remains unexplained, which hinders the Nav1.3 isoform-based DS therapy. I will build upon the recently discovered miRNAs’ (short, non-coding RNA) regulatory effect on SCN1A and 3A genes to elucidate regulation of the isoform transition. My ULTIMATE AIM is to harness the protective effect of the Nav1.3 isoform via miRNA regulation as a DS treatment. I will untangle the miRNA profile of DS from birth to the symptom onset in a well-established mouse model. Through miRNA expression manipulation, I will resolve miRNA function in SCN1A and 3A regulation, its impact on the brain, and ultimately on DS symptoms. My skills in developmental epilepsy models will combine with Prof Henshall’s expertise in miRNA function and use in treatment (shown by miRNA-based treatments for epilepsy in pre-clinical development) to deliver novel treatment options for devastating DS and advance the field of miRNA regulation in the brain. This training & collaboration with top neurobiologists at three excellent institutions – RCSI (host), UA & UMCU (secondment partners) – will advance my skills & employability and propel my career in developmental neurobiology. It will also contribute to the quality of Europe's research and innovation, increasing its competitiveness and attractiveness as a leading research destination.

Keywords: mirna,sodium channel,epilepsy,dravet syndrome,animal models,mirna therapy
Fictional and Impossible objects, Counterpossible reasoning and Thought experiments. A study of medieval theories of impossibility and their contemporary relevance. (FICTA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1481523.0
EU funding (EUR): 1481523.0
Participants: 1
Project status: SIGNED

Medieval philosophical and scientific language, for many centuries and across different traditions, has been overcrowded with entities and scenarios that are – or were thought to be – fictitious or utterly impossible. These are entities like chimeras, flying men, golden mountains, but also atoms, infinite lines, bodies moving in a void space or at an infinite speed. Incorporating these impossibilities in standard theories of inference, showing how impossible statements can be manageable through valid reasoning while producing interesting conclusions, is one of the greatest achievements of the medieval thought. FICTA proposes an innovative, comparative and interdisciplinary approach to investigate the notion of impossibility and its epistemic value in medieval logic, philosophy and science. The project’s main aim is to systematically assess the various ways in which philosophers and scientists in the medieval and post-medieval period theorized the use of counterpossible reasoning – that is, reasoning involving entities, assumptions or scenarios that are physically, metaphysically, or logically impossible. The project also aims to explore the parallels between these historical developments and the thriving contemporary debate related to the use of impossibility, fiction and imagination for epistemic purposes. FICTA’s approach will cross disciplinary boundaries, intersecting the history of medieval and postmedieval logic, medieval literature and art; the history of medieval and early-modern science, and contemporary logic and epistemology. The project’s guiding questions will be the following: How can we obtain new knowledge by starting from impossible assumptions? Which role do impossible entities and impossible assumptions have in the (history of) sciences and in our epistemic endeavor?

Keywords: medieval logic impossibility counterpossibles imagination thought experiments medieval philosophy fiction epistemology of fiction hypothetical reasoning reasoning style medieval literature medieval science history of science
Innovative solutions to prevent, reduce and remediate nutrient pollution along the land-river-sea system in the Mediterranean basin (SEACURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Spain,Italy,Greece,Belgium,Austria
Call: Mission Ocean and Waters and Mission A Soil Deal for Europe – Joint demonstration of approaches and solutions to address nutrient pollution in the landscape-river-sea system in the Mediterranean sea basin (HORIZON-MISS-2023-OCEAN-SOIL-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 8513317.5
EU funding (EUR): 7937485.13
Participants: 25
Project status: SIGNED

The overwhelming scientific evidence provided by the academic corpus indicates that to tackle the origin and negative impacts of nutrient pollution on water, soil and biodiversity, a wide landscape-river-sea system approach needs to be used. This should work on sustainable land management practices (especially, agricultural ones), improved wastewater treatment, and feasible nature restoration strategies. The project SEACURE will aim at demonstrating, scaling up and replicating effective innovations for the systemic prevention and reduction of nutrient pollution in the Mediterranean Sea basin, in line with the innovation ecosystem framework provided by the ongoing Mediterranean Lighthouse projects (as BlueMissionMed) and in close cooperation with related activities implemented by regional soil health living labs in the area. The project is dedicating resources for the regional upscale and replication of successful nutrient management strategies devoted to: i) reduce soil pollution and enhance its restoration; ii) reduce fertilizers use and nutrient losses; and iii) prevent, minimize and remediate nutrients pollution in freshwater and marine ecosystems, in six territorial units (Mar Menor and Central Catalunya in Spain, Po delta and Esino river in Italy, and Axios river delta and Thessaly Plain in Greece). On one hand, the viability and impact will be evaluated. On the other hand, partners will act on innovation levers: policy uptake, societal awareness, capacity building and funding availability. Regional business plans for upscaling the effective strategies in the territorial units will be crafted, taking advantage of the regional mobilisation of innovation ecosystems already carried out during the project. Finally, the replication of knowledge will be encouraged thanks to the technical assistance to Associated Regions through FSTP grants. In summary, the project is embracing the Missions’ impact-driven approach, working with actors to maximise its results’ uptake.

Keywords: nutrient pollution,nutrient management,nitrogen,phosphorus,agriculture,nature based solutions,wastewater treatment,governance
VOICE-CONTROLLED FOOD PROCESSING AND COMPLIANCE ERP SYSTEM FOR THE HOSPITALITY INDUSTRY BASED ON GENERATIVE AI (iFlares)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The food service industry, encompassing restaurants, fast food joints, and cafés, grapples with high staff turnover, labour shortages, significant food waste, and frequent foodborne disease outbreaks. These factors contribute to the industry's low margins and high failure rates. Traditionally, restaurants have struggled to digitalize backend operations due to the hands-on nature of the tasks, rising training costs, the need for extensive customization, and hygiene concerns with using electronic devices near food preparation. To address these operational complexities and ensure consistent quality and compliance across many locations, iFlares has developed a food processing and compliance ERP system. It combines full backend operation digitalization, real-time, on-the-job training, and proactive management through a voice-driven interface that seamlessly integrates into daily activities. This allows iFlares to achieve brand consistency in operations, quality, and safety standards across all locations at significantly lower costs in the set-up and operation of control systems and personnel training. iFlares not only helps mitigate traditional industry challenges but also sets new standards for integrating digital technologies in fast-paced, hands-on work environments, ultimately supporting businesses in maintaining consistency and reducing operational risks.

Keywords: hospitality industry,digital transformation,restaurant back end processes,food processing and compliance erp system,continuous on the job training system for restaurants
Wingcopter Medical Drone Delivery (WMDD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Wingcopter was founded in 2017 when the founders received the EXIST grant from the German government that financed the spin off from the Technical University of Darmstadt. Our purpose is to improve and save lives, by creating efficient and sustainable Unmanned Aerial Vehicles (“UAVs”) delivery solutions targeting healthcare logistics applications starting with the medical courier market. We design, manufacture, distribute, and operate innovative UAVs in the <25kg category that fly autonomously Beyond Visual Line Of Sight (BVLOS) to address delivery challenges faced in the medical courier market, which arise from the current delivery systems served by a combination of trucks and helicopters, which are expensive to operate and maintain. The product development and production of UAVs takes place at our headquarters in Weiterstadt, Germany. The sale, delivery, and operation of UAVs will take place on the global stage. We have 157 employees worldwide, with 145 based in our primary facilities in, Germany, where our main office and production space is, we also have testing facilities in, Spain, Malawi, and the US. Chronic diseases are the leading cause of deaths in the EU. Globally the number of people suffering from chronic diseases will rise from 426m in 2022 to 535m in 2030, increasing the burden of care on struggling health systems. Our UAVs provide a reliable, fast and environmentally-friendly supply and cold chain solution independent of weather, topography, road-infrastructure, and congestion. This solution integrates into existing local and regional medical supply chains to deploy in a hub and spoke model connecting hospitals, laboratories, and remote health care centres. Our UAV solutions have the potential to improve quality health care access of patients and to increase the efficient usage of medical supplies and services, while reducing the carbon emissions of the logistics industry and contributing the EU tech sovereignty and jobs growth.

Keywords: logistics,sustainable transport,transport aviation,network infrastructures,distribution and logistics,supply chain management