Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering and Exploiting the chemical features of Silent Lipopolysaccharides: a gift from gut microbiota (DEBUGGING-LPS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2028-09-30
Duration (months): 72.0
Total project cost (EUR): 1954308.0
EU funding (EUR): 1954308.0
Participants: 1
Project status: SIGNED

Gut Microbiota is a key actor for human health, driving many physiological and pathological processes, including immune system development and modulation. How this massive population of microorganisms, most of which are bacteria, establishes commensal, mutualistic or pathogenic interactions with the human host despite the vigilance of the immune system, is still obscure and requires an in-depth study. The story gets more intricate considering that gut is home for a myriad of Gram-negative bacteria whose outer membrane main constituent is the lipopolysaccharide (LPS). Due to its chemical structure, LPS is considered a potent elicitor of immune inflammatory reactions in mammals, being usually associated to perilous bacteria and detrimental outcomes for human health. Nevertheless, LPS also decorates the membrane of harmless and beneficial Gram-negatives of gut microbiota. How LPS is tolerated and remains (apparently) silent in the gut is a major unsolved question representing a frontier in our understanding of innate immunity. DEBUGGING-LPS project will contribute to answer this question, starting from the assumption that the chemistry of LPS is the real message taken from human host of the bacterial interaction, either beneficial or harmful. Strategically based on my expertise in organic chemistry, and integrating synthetic chemistry and cellular immunology studies, DEBUGGING-LPS will decrypt the 'chemical language' spoken by LPS in the gut. This project will deliver a clear picture of the chemistry at the basis of the difference between 'good' and 'bad' LPS, providing tools for the exploitation of the acquired knowledge to create novel therapeutics for resolving/mitigating immune disorders. DEBUGGING-LPS has been conceived to go beyond the state-of-the-art, breaking the dogma of LPS as an enemy, leaving space for a new vision of this glycomolecule: i.e. no longer as a toxic bacterial product rather as an immune signal vital for the proper functioning of our body.

Keywords: structural glycoscience,glyco immunology,chemical and chemoenzymatic synthesis,gut microbiota,immune modulators,microglia,neural differentiated induced pluripotent stem cells
Beyond Low-Rank Factorizations (eLinoR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1982515.0
EU funding (EUR): 1982515.0
Participants: 1
Project status: SIGNED

Low-rank matrix factorizations (LRMFs), such as principal component analysis, nonnegative matrix factorization and sparse component analysis, are linear dimensionality reduction techniques and are powerful unsupervised models to represent and analyze high-dimensional data sets. They are used in a wide variety of areas such as machine learning, signal processing, and data mining. Many LRMFs have been proposed in the literature, in particular in the last two decades, and used extensively in many applications, such as recommender systems, blind source separation, and text mining. Although LRMFs have known and still know tremendous success, they have several limitations. Two key limitations are that they are linear models, and that they only learn one layer of features. In this project, we go beyond LRMFs, considering generalized LRMFs (G-LRMFs) that overcome these limitations, considering non-linear and deep LRMFs. These generalizations have been introduced more recently, and they have hardly been explored compared to LRMFs. In particular, eLinoR will focus on three fundamental aspects: (1) Theory: understand G-LRMFs with a focus on computational complexity and identifiability (uniqueness of the decompositions), (2) Algorithms: solve G-LRMFs via provably correct and heuristic algorithms, and (3) Models: design new G-LRMFs for specific applications. This unified approach will enable us to understand these problems better, to develop and analyze algorithms, and to then use them for applications. The novelty and ground-breaking nature of this project also lies in the methodology, exploring G-LRMFs from different but complementary perspectives, bringing together ideas from different fields. The ultimate goal of eLinoR is to provide practitioners with theoretical and algorithmic tools for G-LRMFs, allowing them to decide which model and algorithm to use in which situation and what kind of outcome to expect, leading to a widespread and reliable use of G-LRMFs.

Keywords: linear dimensionality reduction,low rank matrix factorization,nonnegative matrix factorization,deep matrix factorization,nonlinear matrix factorization
Liquefaction-proof design of houses: key insights and tools (LiqproofHouses)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 3
Project status: SIGNED

Soil liquefaction during earthquakes has been a problem of great concern in earthquake engineering for more than half a century. Yet, many small-scale structures, such as low-rise houses, are still designed without consideration of the effect of liquefaction and have thus suffered extensive damage in several recent earthquakes. Liquefaction mitigation measures involving pile foundations or extensive ground improvement are expensive solutions for residential properties underlain by deep liquefiable deposits. Such structures can be more efficiently designed with partial-depth ground improvement, i.e. allowing limited extent of liquefaction at larger depths. This idea is less costly and more sensible for residential buildings, but it requires reliable assessment of the liquefaction response to ensure that any induced deformations can be well-tolerated by the structure. Also, this assessment should consider the entire range of earthquake loads occurring during the life of the structure. The proposed project aims to provide the means for such a holistic assessment of the liquefaction performance of low-rise buildings. Specific emphasis will be placed on quantification of ejecta-induced damage resulting from a discharge of liquefied soils at the ground surface. This quantification will be based on an integration of insights and data from nonlinear dynamic analyses, seismic centrifuge tests, and case-history observations. A procedure for estimating ejecta-induced settlement will be developed and used alongside existing shear-induced settlement models within a novel framework for holistic evaluation of the liquefaction performance. The key objective of this framework is to guide the design process by providing an in-depth understanding of the characteristics of the liquefaction-building system response and the effect of ground improvement for different levels of shaking. The proposed project will contribute to improved physical and societal resilience to earthquakes.

Keywords: soil liquefaction earthquake engineering geotechnical engineering geotechnical centrifuge performance based design settlement
Strengthening CBRNE Talent Development and Cross-Sector Innovation for a Safer Future (SPARKUP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Serbia,Hungary,Italy,Netherlands,France,Slovakia,Romania,Switzerland
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 2284706.25
EU funding (EUR): 2284706.25
Participants: 10
Project status: SIGNED

SPARKUP proposal is motivated by the pressing need to address the increasing risks posed by CBRNE threats, particularly in the Southern CEE region. This region faces unique challenges due to its proximity to the ongoing conflict in Ukraine and other geopolitical instabilities. The urgency to strengthen the region's preparedness and response capabilities is paramount, necessitating a robust approach to research and innovation in the field. SPARKUP seeks to bridge gaps in the European Research Area (ERA) by enhancing the interoperability of careers across academic and non-academic sectors, thereby improving the employability of R&I talents. By fostering greater collaboration and knowledge exchange SPARKUP aims to create a more dynamic and integrated research ecosystem. By enhancing career prospects SPARKUP not only contributes to the retention of top talents within Europe but also ensures that researchers are better equipped to address the complex challenges posed by CBRNE threats. The project aims to deliver a strategy that includes a targeted upskilling programme designed to equip researchers and innovators with the necessary skills to excel in their careers. This approach not only boosts employability but also ensures that the next generation of CBRNE experts is capable of responding effectively to the specific risks faced by the Southern CEE region. The project is structured around three main pillars: (1) Comprehensive talent development and circulation activities will be launched to swiftly force collaborations of academic and non-academic sector. (2) The project will establish the groundwork for sustainable talent management and R&I capabilities within the region's leading CBRNE academies through organized knowledge transfers and shared infrastructure. (3) A Center of Excellence will be established at UCPS, positioning it as a flagship institution in the Southern CEE region for talent development, R&I support, and cross-sectoral knowledge exchange.

Keywords: cbrne,talent management,training programme
Boosting Societal Adaptation and Mental Health in a Rapidly Digitalizing, Post-Pandemic Europe (Bootstrap)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Germany,Hungary,Portugal,United Kingdom,Spain,Netherlands,France,Italy,Switzerland,Gibraltar,Israel,Estonia,Lithuania,Australia
Call: Boosting mental health in Europe in times of change (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 5416580.34
EU funding (EUR): 5416580.34
Participants: 26
Project status: SIGNED

BACKGROUND: Adolescents are at particularly high risk for digital technology overuse, including in response to the COVID pandemic, and are therefore vulnerable for its potential harmful effects on mental health. Problematic usage of the internet (PUI) is thought to represent a marker of disrupted self-management, with major consequences for individual and societal health and wellbeing. AIM: Bootstrap brings together a multidisciplinary consortium aiming to initiate health and social policy and practice change designed to reduce the harmful effects of digitalization on mental health, particularly for young people. APPROACH: We will co-create a digital screening and assessment platform to understand which individuals are at-risk for developing PUI. Algorithm-based models will be used to predict which individual will benefit from which type of self-management intervention, and these preventative behavioral interventions will be tested for their (cost)effectiveness. Finally, we will develop a policy toolkit in co-design with stakeholders, to promote human digital rights accountability at the local, national, and European level. IMPACT: Bootstrap will provide unprecedented scientific knowledge on the psychological mechanisms underlying (risk for) PUI and potential interventions. Improved self-management and tools to optimize healthy internet usage will promote mental health and prevent mental ill health in adolescents, and contribute to reducing stigma. In addition, our policy toolkit will empower policy makers and private companies to (self)regulate with the intent to protect vulnerable groups. In the long run, Bootstrap will thus contribute to improving mental wellbeing across Europe and beyond.

Keywords: problematic usage of the internet risk assessment self management personalised prevention digital intervention policy change adolescent mental health digital human rights
Nonlocal integrable equations: blow-up phenomena and beyond (NIEB-PHAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: SIGNED

I will carry out this fellowship at the University of Oslo, under the supervision of Professor Kenneth Karlsen at the Department of Mathematics. The project is devoted to study existence and blow-up properties of the solutions of initial value problems (IVPs) for nonlocal nonlinear integrable PDEs. Nonlocal integrable equations were introduced by M. Ablowitz and Z. Musslimani in 2013 and have become a hot topic in the theory of integrable systems. By applying inverse scattering transform (IST) method it was shown that soliton solutions of nonlocal equations blow-up in isolated points in x,t plane. Therefore the natural question is to study the existence and blow-up properties of the general IVPs for such equations. To this end we will use the mixture of the IST method and PDE techniques. The former will be used for predicting the presence and the form of the blow-up of the solution, while the PDE approaches will be used for describing the blow-up of the solution of the general IVP and for finding a suitable concept of a weak solution, which exists even after the collapse. Also by the IST method it was shown that apart from zeros, which correspond to solitons, the associated to the initial data spectral functions have the new type of singularities. These singularities correspond to the winding of the argument of the spectral function and play a significant role in long-time asymptotic behavior of the solutions ? they are responsible for a transition between qualitatively different asymptotic zones in x,t plane. It is a challenging open problem to describe analytically the nonlinear effects corresponding to these new singularities and in the framework of the project we are going to investigate this phenomena numerically. The fellowship will allow me to expand my skills in PDE methods, which is different, but related to my present expertise field. Also it will enable me to become an established interdisciplinary researcher, who could pursue top academic positions.

Keywords: nonlinear integrable pdes,blow up phenomena,well posedness theory,inverse scattering transform method
Diagnostic Tools and Risk Protocols To Accelerate Underground Hydrogen Storage (HyDRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,United Kingdom,Italy,Spain,Germany,New Zealand,Austria
Call: Investigation of microbial interaction for underground hydrogen porous media storage (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2028-02-29
Duration (months): 38.0
Total project cost (EUR): 3160555.4
EU funding (EUR): 3016110.22
Participants: 20
Project status: SIGNED

The overall goal of the HyDRA project is the “Characterisation of hydrogen-consuming microbial activity and interaction with the storage formation to determine guiding principles that mitigate risk and enable fast-tracking of porous media underground storage as part of the European hydrogen ecosystem”. Our goal is achieved through 10 quantifiable key objectives, including: standardized field sampling protocols and bio-geochemical laboratory methods, mapping microbial taxonomic and functional diversity across Europe, deriving models that enhance and upscale laboratory bio-geochemical findings for site-specific microbial risk assessment, delivering a fast-track site selection tool with predictive microbial risk index, updating guidelines to support storage site operators (SSOs) in their site-specific risk identification and management. Targeting the full diversity of geology and subsurface conditions encountered across the different European storage sites, the interdisciplinary HyDRA research partners and associated SSOs will assess microbial risks associated with the storage of hydrogen in porous reservoirs. Across 12 work packages, the HyDRA project will generate new fundamental understanding of microbial risk and mitigation in the context of underground hydrogen storage. With an interdependent workflow across relevant disciplines (microbiology, geosciences, geophysics and -chemistry, porous media modelling, and safety/risk assessment), HyDRA research focuses on the elusive interplay between microbiology, geochemistry, and hydrogen flow during underground hydrogen storage in porous media. Addressing this knowledge gap – across the full spectrum of site- and operational conditions for active and future hydrogen storage sites, amplified by natural hydrogen seeps – will support the development and standardization of site-specific and general guidelines and regulation codes for an accelerated and widespread European underground hydrogen storage deployment.

Keywords: underground hydrogen storage,microbial risk,bio geochemical processes,porous media,microbial kinetics dynamics,bio geochemical modelling,risk identification management,natural hydrogen seeps
Deciphering the newly discovered branchial cavity immune surveillance system to protect fish against infectious diseases in aquaculture. (Fish-S.H.I.E.L.D.)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2499205.0
EU funding (EUR): 2499205.0
Participants: 1
Project status: SIGNED

The sustainability of aquaculture, an important food source for human, is severely challenged by infectious diseases. Unfortunately, the development of new therapies and vaccines is hindered by our incomplete understanding of the fish immune system. The lack of knowledge of the mechanisms governing immune responses in the branchial cavity is particularly alarming considering that it represents a main port of entry for pathogens and is involved in many pathologies affecting farmed fish. Recent findings of new lymphoid tissues, bound together by a previously unknown tonsil-like organ inside an even larger lymphoid network revealed the branchial cavity as an unsuspected important region of the fish immune system. The main objective of this project is to characterize this newly discovered branchial cavity immune surveillance system to harness its potential against infectious diseases in aquaculture. Toward this goal, the project will take advantage of the zebrafish model to achieve the following objectives: 1) Characterize the newly discovered lymphoid tissues and tonsil-like organ. 2) Decipher the rules of antigen sampling and transport in the branchial cavity. 3) Characterize the development of the branchial cavity lymphoid architecture. 4) Decipher the roles of the branchial cavity immune surveillance system in immune responses to infection and vaccines. In a comparative effort, the project will then study the branchial cavity immune system in Atlantic salmon and other fish species relevant for aquaculture. The methodology will combine sophisticated immunohistology, nanotechnologies, state-of-the-art transcriptomic analysis, antibody-assays, and advanced 3D microscopy. The project will progress far beyond the current knowledge in fish immunology, which could drastically impact current paradigms in the field, open new perspectives for fish vaccination and diseases monitoring in aquaculture, and has the potential, in the long term, to positively impact human health.

Keywords: fish immunology,aquaculture