Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic and environmental factors that control inflammation-driven colon cancer (INCA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: United Kingdom
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-03-01
End date: 2019-02-28
Duration (months): 60.0
Total project cost (EUR): 2484620.0
EU funding (EUR): 2484620.0
Participants: 1
Project status: CLOSED

The human gastrointestinal tract is colonized by an abundant and diverse bacterial microbiota that exist in a mutualistic relationship with the host that promotes intestinal health. Maladaptation in this host microbial dialogue leads to a deranged inflammatory response and inflammatory bowel disease (IBD) that can progress to colon cancer. The complex interplay between genetic and environmental factors and their impact on intestinal inflammation are starting to be deciphered in IBD, however little is known about how they influence the transition from colitis to cancer. We recently established a relevant model of bacteria-driven invasive colon cancer and have mapped both genetic and immune pathways that perpetuate disease. Genetic susceptibility maps to a 1.7mb region on chromosome 3 containing the candidate gene Alpk1, an alpha-kinase. This locus mediates its effects through the IL-23 driven innate lymphoid cell response and we have identified the cytokine IL-22 as a key player in driving the tumour cell response. We will use a multi-disciplinary approach to probe the interaction between genetics, microbial drivers and inflammatory pathways that promote colon cancer. BAC transgenics and cell-type specific knock-out mice will be used to establish the function of Alpk1 in bacteria driven colon cancer. In vivo models will be complemented by novel 3D colonic organoid and crypt cultures generated from epithelial stem cells from normal or tumor tissue allowing analysis of microbial and cytokine signals that influence intestinal epithelial cell and stem cell function. Deep sequencing combined with bacterial cell culture will identify changes in the intestinal microbiota that drive tumourigenesis. Results from mouse models will be translated to analysis of human colorectal cancer. These studies will uncover new pathways involved in bacterial interaction, intestinal inflammation and tumour formation that may offer new therapeutic targets in IBD and colon cancer.
Plasmon-based Functional and Quantum Nanophotonics (PLAQNAP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Denmark
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2020-01-31
Duration (months): 72.0
Total project cost (EUR): 2278636.0
EU funding (EUR): 2278636.0
Participants: 1
Project status: CLOSED

Plasmon-based nanophotnics, an explosively growing research field concerned with surface-plasmon waveguides and circuitry, is oriented towards exploiting unique perspectives opened for radiation guiding along metal surfaces: extreme mode confinement (i.e., far beyond the diffraction limit) and seamless interfacing of electronic and photonic circuits (that both utilize the same metal circuitry). At the same time, unavoidable radiation absorption by metals results in the fundamental trade-off between the mode confinement and propagation loss, so that the problem of making the most of the above unique features becomes of paramount importance. The proposal encompasses two ground-breaking research directions in plasmonics that explore and utilize extremely confined plasmon-waveguide modes for functional and quantum nanophotonics. These directions of in-depth investigations concentrate within two interrelated and largely unexplored research areas within plasmonics: development of ultra-compact plasmonic configurations exhibiting unique functionalities and realization of strong coupling between extremely confined plasmonic modes and individual quantum emitters. Fundamental studies of ultimate mode confinement and coupling to quantum emitters would evolve into investigations carried out within forefront topics including (i) dynamic control of plasmon-waveguide modes using the same metal circuitry for both radiation guiding and its control with electrical signals; (ii) moulding the radiation flow by gradually varying waveguide cross sections in order to realize efficient nanofocusing of radiation, miniature ultra-dispersive wavelength-selective components and table-top models of plasmonic black holes, and (iii) quantum plasmonics with individual quantum emitters being strongly coupled to deep subwavelength surface plasmon modes, targeting the realization of a saturable waveguide mirror, single-photon transistor and long-distance entanglement of two remote quantum emitters.

Keywords: nanoplasmonics,plasmonic waveguide components,quantum plasmonics
Unraveling sex determination and parthenocarpy mechanisms to improve crops (SEXYPARTH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: France
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-04-01
End date: 2020-03-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

In the last century, the use of high-yielding F1-hybrid varieties, mechanization and irrigation have insured yield improvement for major crops. In the post-genomic era, one would expect that the discovery and the optimization of the gene networks controlling key agronomic traits could contribute to another level of yield improvement. In this scenario, leader alleles will be identified and combined to produce new plant prototypes. Our proposal aims to investigate unisexual flowers development and parthenocarpy in Cucurbitaceae species and to produce new plant prototypes adapted to specific growing conditions. The rationale behind choosing plants from this family as a model system is justified by the widespread of sex morphs and the major role of many species of this family in food security. Our recent work on sex determination which led to the isolation of the first naturally occurring sex determination genes in plants, has set the ground for this project. The proposal relies on integrative analyses of datasets that will be obtained from the combination of different “omics” and genetic tools. Specific objectives include the (i) Determination of the gene networks controlling unisexual flower development and fruit shape, (ii) Comparative analysis of the sex genes in Cucurbitaceae species of different sexual morphs (iii) Determination of the gene networks controlling parthenocarpy and (iv) Production of new plant prototypes of major and orphan cucurbits and detailed phenotyping for yield. Outcomes will be transferred to the major Cucurbitaceae, melon, watermelon, cucumber and zucchini, as well as the orphan crop, bottle gourd. Cucurbitaceae in this project are considered not only as plant to improve but also as a model system to bring new insights to two breeding traits, unisexual flower development and fruit setting.

Keywords: molecular plant breeding,cucurbitaceae,sex determination,parthenocarpy
Hydrodynamical simulations of protoplanetary discs in the era of ALMA imaging (DISCSIM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: United Kingdom
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2019-01-31
Duration (months): 60.0
Total project cost (EUR): 1892844.0
EU funding (EUR): 1892844.0
Participants: 1
Project status: CLOSED

This is a proposal for an ambitious programme of state of the art hydrodynamical simulations, designed to answer some key questions about the role of disc self-gravity in planet formation. The programme is also designed so as to maximize the synergy with the new observational constraints from high resolution imaging data from the Atacama Large Millimetre Array that will become available over the timescale of the grant. The five year programme should provide definitive answers about whether planet formation is able to get going during the early, self-gravitating phase of disc evolution and how, if so, it would affect the further evolution of the disc. The topic of gravitational disc fragmentation as a route to planet formation is currently in a state of crisis, with recent simulations undermining what had become a consensus view on the subject. A dedicated and carefully constructed approach, as detailed here, is required to solve this problem.

Keywords: hydrodynamic and radiative transfer modeling
Optical Ultra-Sensor (OPUS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Sweden
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-11-01
End date: 2021-02-28
Duration (months): 76.0
Total project cost (EUR): 2499958.0
EU funding (EUR): 2499958.0
Participants: 2
Project status: CLOSED

This project aims at pushing the limits of optical sensing on a microchip by orders of magnitude, thereby allowing for ultra-high sensitivity in optical detection and enabling first-time-ever demonstrations of several optical sensing principles on a microchip. My idea is based upon our distributed-feedback lasers in rare-earth-ion-doped aluminum oxide waveguides on a silicon chip with ultra-narrow linewidths of 1 kHz, corresponding to Q-factors exceeding 10^11, intra-cavity laser intensities of several watts over a waveguide cross-section of 2 micrometer, and light interaction lengths reaching 20 km. Optical read-out of the laser frequency and linewidth is achieved by frequency down-conversion via detection of the GHz beat signal of two such lasers positioned in the same waveguide or in parallel waveguides on the same microchip. The sensitivity of optical detection is related to the laser linewidth, interaction length, and transverse mode overlap with the measurand; its potential of optically exciting ions or molecules and its optical trapping force are related to the laser intensity. By applying novel concepts, we will decrease the laser linewidth to 1 Hz (Q-factor > 10^14), thereby also significantly increasing the intra-cavity intensity and light interaction length, simplify the read-out by reducing the line-width separation between two lasers to the MHz regime, and increase the mode interaction with the environment by either increasing its evanescent field or perpendicularly intersecting a nanofluidic channel with the optical waveguide, thereby allowing for unprecedented sensitivity of optical detection on a microchip. We will exploit this dual-wavelength distributed-feedback laser sensor for the first-ever demonstrations of intra-laser-cavity (ILC) optical trapping and detection of nano-sized biological objects in an optofluidic chip, ILC trace-gas detection on a microchip, ILC Raman spectrometry on a microchip, and ILC spectroscopy of single rare-earth ions.

Keywords: optical sensor,intra-laser-cavity sensor,distributed-feedback laser,optofluidics,trace-gas sensing,raman spectroscopy,single-ion spectroscopy
Fusion Technology Transfer Action (FUTTA)

Framework: FP7 — Euratom
Programme: Fusion Energy
Destination: Support Actions
Action type: Coordination and support actions
Countries involved: France
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 306492.82
EU funding (EUR): 250000.0
Participants: 1
Project status: CLOSED

EFDA continues to drive the development of a range of technologies that will be central to the ultimate goal of power generation from nuclear fusion, namely plasma physics, materials and diagnostics. The EU recognizes the potential of these EFDA technologies, and is looking to record and maximize the potential from technology transfer. It addition the EU wishes to create a dedicated in house Technology Transfer capability based on best practice. This proposal is presented by the Technoloy Transfer Programme Office of the European Space Agency. The objectives of the activity are: To capture, record and publicise the successes from Technology Transfer that have to date been created as a consequence of EFDA technology development. To increase the amount of Technology Transfer from EFDA Associates to industry and society in general. To assist the EU in the establishment of a Technology Transfer capability dedicated to EFDA activities. To ensure maximum synergy in technology transfer between EFDA and other EIROFORUM members such as ESA and CERN.

Keywords: technology transfer fusion brokerage
Organising and delivery of the Irish Presidency Conference on the European Strategic Energy Technology Plan ("SET-Plan") (SET_IRELAND)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy
Action type: Coordination and support actions
Countries involved: Ireland
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-02-01
End date: 2013-07-31
Duration (months): 6.0
Total project cost (EUR): 248010.0
EU funding (EUR): 124005.0
Participants: 1
Project status: CLOSED

This project focuses on organising and delivery of the Irish Presidency Conference on the European Strategic Energy Technology Plan (SET-Plan).

Keywords: set plan,ireland
Support to the Chair and Vice-Chairs of the ERC Scientific Council 2013 (ERCSC-CHAIRS-SUP2013)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Austria
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 323600.0
EU funding (EUR): 299485.0
Participants: 1
Project status: CLOSED

The proposed Action will provide the necessary support to the Chair and Vice-Chairs of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required in the fifth year of implementation of the Ideas specific programme. The proposed project aims to support the ScC Chair and Vice-Chairs, who, like other ScC members, are acting in a part-time capacity, in the efficient and timely achievement of the ScC’s objectives in 2013. It will support and assist Professor Helga Nowotny, Chair of the ERC’s ScC, Professor Pavel Exner, and Professor Carl-Henrik Heldin, Vice-Chairs of the ERC’s ScC, in their diverse responsibilities which include the achievement of efficient and effective functioning of the ScC, its integrated operation together with the ERC Executive Agency (ERCEA), and effective interfacing with the scientific community, other funding agencies and the political institutions of the European Union. The project will provide administrative and research support ranging from secretarial tasks to assistance in developing policy papers related to the work of the Chair and Vice-Chairs of the ERC ScC for a period of one year.

Keywords: european research council,scientific council chair
Energy management and decision support systems for Energy Positive neighbourhoods (EEPOS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for a low carbon economy
Action type: Collaborative project
Countries involved: Finland,Austria,Germany,Germany,Spain,Spain
Call:  (FP7-2012-NMP-ENV-ENERGY-ICT-EeB, 2012)
Start date: 2012-10-01
End date: 2015-09-30
Duration (months): 36.0
Total project cost (EUR): 4152984.0
EU funding (EUR): 2872594.0
Participants: 9
Project status: CLOSED

EEPOS focuses on neighbourhood energy management and decision support systems that will integrate local consumers & producers (prosumers) with the main electrical and heating grids. The objectives are to develop: • Visionary scenarios and business models for neighbourhood energy services for energy trading between prosumers in neighbourhoods and the grid. • Management systems for energy positive neighbourhoods. • Information and decision support system for optimising the use of energy beyond the buildings. • Methods for end-user engagement and interfaces to support them with relevant information. • Validation in real environments and virtual simulations. The expected progress beyond the state-of-the-art includes e.g.: • New business models and services. • Neighbourhood level energy management system with open interfaces to the grids and local prosumers. • Tools for engagement and motivation of users tool utilising new approaches like gaming, social networking, crowd sourcing etc. • Simulation based evaluations of alternative energy efficiency strategies. The S/T methodology is to: • Identify business models and ICT requirements for supporting energy positive neighbourhoods. • Develop and integrate energy management and decision support systems between three levels: grids, neighbourhoods and local prosumers. • Validate the systems in real environments and complementary virtual simulations. The consortium includes 8 academic, industrial and public organisations from 4 countries in different EU climate zones. They combine unique expertise in building services, building management systems, energy efficiency services, end-user needs and interfaces, renewable energy systems, monitoring and energy efficiency focused productivity tools. The consortium will engage with relevant stakeholders in an early stage of the projects in order to ensure acceptability and impact of the results, and disseminate its findings to them.

Keywords: neighbourhood,energy management,decision support,user engagement,information model,predictive control,gateway.
Energy Positive Neighbourhoods Infrastructure Middleware based on Energy-Hub Concept (EPIC-HUB)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for a low carbon economy
Action type: Collaborative project
Countries involved: Italy,Italy,Switzerland,Serbia,Spain,Spain,Czechia,Israel,Spain
Call:  (FP7-2012-NMP-ENV-ENERGY-ICT-EeB, 2012)
Start date: 2012-10-01
End date: 2016-04-30
Duration (months): 43.0
Total project cost (EUR): 6720937.0
EU funding (EUR): 4212340.0
Participants: 11
Project status: CLOSED

The goal of EPIC-HUB is to develop a new methodology, an extended architecture and services able to provide improved Energy Performances to Neighbourhoods (NBH). By combining powerful Energy-Hub-based Energy Optimization capabilities with seamless integration of pre-existing and new ICT systems, EPIC-HUB will contribute to achieve the global objective of the Energy-positive Neighbourhood. EPIC-HUB covers all the aspects directly or indirectly connected to efficient Energy-based Management, Control and Decision-Support at neighbourhood-level, and defines a Fully-Interoperable Middleware solution able to provide integration and a structured vision of the overall infrastructure, friendly usable by all the involved stakeholders (e.g. the energy managers and utilities). By exploiting the concept of Energy Hub, EPIC-HUB Middleware will focus on energy usage optimization at neighbourhood level: EPIC-HUB will define a “neighbourhood-aware” energy trading platform that will improve Energy Efficiency and reduce the energy cost, taking into account Renewable Energy Sources as well as the Electricity Distribution Grid. The adaptability of the EPIC-HUB approach will be demonstrated by the implementation of different pilots with highly motivated communities: As a matter of fact the Genoa Port (Italy), Belgrade Airport (Serbia) and Bilbao Exhibition/Fair Centre (Spain) will host very challenging pilots, involving their respective neighbourhood use-cases, and demonstrating how critical infrastructures can benefit from innovative Energy Management. The involvement of the neighbourhoods operators, the Energy utilities and the local Public Authorities will allow EPIC-HUB to effectively tackle the development of innovative Business Models, with a clear validation of the project results including impacts on economic and business development, as well as carbon reduction.

Keywords: energy hub,middleware,ict integration,neighbourhood,energy positive,energy market trading,near-zero carbon emissions,res integration
International Post-Doc Initiative of the Technische Universität Berlin (IPODI) (IPODI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-COFUND, 2012)
Start date: 2013-07-01
End date: 2018-06-30
Duration (months): 60.0
Total project cost (EUR): 3405990.0
EU funding (EUR): 1362396.0
Participants: 1
Project status: CLOSED

The International Post-Doc Initiative of the Technische Universität Berlin (IPODI) aims to promote the career development of experienced female researchers within ERA. IPODI offers in total 21 fellowship positions which will be allocated in three internationally open selection rounds with international peer review. A 24 months employment contract including social security insurance, pension coverage, as well as travel and training allowances will be offered to the successful candidates. IPODI seeks not only to increase the number of women in higher qualification levels of science, in particular in engineering science or natural science – as the Marie Curie Programme do. Above all, its main objective is to prepare highly qualified women for leadership positions in science. Thus, the challenging demand of the European Commission in implementing sustainable gender equality in science shall be realised. On the basis of scientific excellence and innovation – reflected by the excellent research environment of TU Berlin - the fellows are free to choose their own research project in one of the 7 faculties. A transparent selection process guarantees a high quality standard by international peer review. Moreover, intersectoral cooperation will be guaranteed by a close network with the private sector. Fellows will profit from these collaborations and can integrate intersectoral elements to their research career. Mentoring as a cross-generational coalition is another main element of IPODI. Therefore, a senior researcher of TU Berlin will give support as mentor. Qualified staff will ensure an open information policy by managing 3 internationally advertised calls, releasing the selection criteria and communicating the rationale behind the final decisions. IPODI will make a contribution to advancing the scientific potential of female researcher within ERA by combining intersectorality, mentoring and transdisciplinarity.

Keywords: training through research,mentoring,international science networks,intersectoral cooperation,women in science,mobility,training for leadership positions,transdisciplinary research