Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multilingual sentence processing in real-time (INSPIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: SIGNED

The project INSPIRE (multilINgual Sentence Processing In Real-timE) will investigate two potential factors that influence multilingual sentence processing, cross-linguistic influence and language dominance, to shed light on the ongoing debate about how the language systems in a multilingual speaker's mind/brain interact. We will employ two time-sensitive methods, eye-tracking and mouse-tracking, to investigate how German native speakers living in Norway and non-native speakers of German whose native language is Norwegian process German case marking in different sentence structures (transitive structures, ditransitive structures); the findings will be compared to those obtained from a group of German native speakers in Germany. The language combination was chosen because it enables us to test whether the groups differ in how they use morphological case and word order to identify who did what to whom in a sentence. Unlike German, Norwegian has no morphological case on full noun phrases, but mostly relies on word order for sentence interpretation. Our experimental design not only enables us to investigate whether non-native speakers are affected by cross-linguistic influence from their first language (Norwegian) when processing German (and rely more on word order than case), but also how a change in language dominance affects sentence processing in German native speakers, i.e., whether they show a processing pattern that is more similar to that of the non-native group after longer exposure to and usage of Norwegian. Thus, unlike previous studies, INSPIRE will reveal whether cross-linguistic influence is bidirectional. The project will fill a gap in current research on language attrition by investigating real-time processing and will inform us how the lack of input and use can affect the processing of the first language. INSPIRE addresses aspects that are relevant for all who have to deal with multilingualism in their daily life (e.g., language therapists and teachers).

Keywords: multilingualism,cross linguistic influence,language processing,prediction
TRAF-STOP therapy to reduCe inflammation in athERosclerosis. (TRACER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Atherosclerosis, the underlying cause of the majority of cardiovascular diseases, is a lipid driven, inflammatory disease of the large arteries. Despite a 25% relative risk reduction achieved by lipid-lowering treatment, the vast majority of atherosclerosis induced cardiovascular disease risk remains unaddressed. Therefore, characterizing mediators of the inflammatory aspect of atherosclerosis is a widely recognized scientific goal with great therapeutic implications. Blocking the co-stimulatory CD40L-CD40 dyad reduces atherosclerosis. However, long-term inhibition of CD40L or its receptor CD40 results in suppression of the immune system and poses a risk for thromboembolic events. Therefore, we focused on the downstream signaling pathways of CD40, and found that the interaction between CD40 and TNF-receptor-associated factor 6 (TRAF6) is the driving force for atherosclerosis. Using virtual ligand screening, we identified several small molecule inhibitors termed TRAF-STOPs that were modeled to bind to the CD40-binding domain of TRAF6. TRAF-STOPs significantly reduce (existing) atherosclerosis and treatment was well tolerated. The first toxicology results in mice show that there are no side effects. Here we pursue the hypothesis that TRAF-STOPs are excellent candidates to pass the translational pipeline towards a clinical application to treat atherosclerotic cardiovascular disease. Prof. Lutgens is one of the founders of the recently established start-up company Cartesio Therapeutics to be able to valorise our novel TRAF-STOPs. By the end of the PoC grant, we expect to have an oral drug available and to have completed toxicology and bio-distribution analysis in a large animal model (mini-pig) and have tested TRAF-STOPs in a pig model of atherosclerosis. This way, we hold a solid business case in our hands. The resulting business- and (pre-)clinical development plan and patent portfolio will then be ready for seed investment and venture capital funding.

Keywords: cardiovascular disease,atherosclerosis,inflammation,small molecule inhibitors
The Intersectional Politics of Antagonism in Peacebuilding (IPAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The Colombian peace process signed in 2016 has shown that even when peace agreements include comprehensive measures to tackle structural inequalities seen as the root causes of the conflict, they may still be rejected by the very societal groups meant to benefit from such transformative provisions. IPAP addresses this dilemma by exploring how peacebuilding institutions can implement a peace agreement that is contested and work to include groups who have engaged in antagonistic actions against the peace accord. The research counters a tendency in the literature to treat resistance against peacebuilding as deviance or abnormality or as a mere manifestation of political and economic elites’ fear of losing power, by including the intersectional politics which explains these groups’ undermining or rejection of the peace process. The objectives of IPAP are: 1) to identify the fabric of antagonistic forces to peace and map their relations with political actors; 2) to examine the intersectional systems of power differentials through which antagonistic subject positions emerge and analyse how they transform into agonistic, i.e. constructively conflictive, relations with the work of peacebuilding institutions; 3) to explore possibilities for peacebuilding institutions to gain sustained legitimacy among the local population; 4) to identify ways in which peace institutions might engage with difference and create spaces where adversaries can engage in agonistic dialogue. To achieve these objectives, IPAP uses a feminist intersectional lens to peacebuilding, and an ethnographic fieldwork approach, to empirically study Colombia as a rich case of antagonism to peacebuilding. The innovative approach of IPAP consists in advancing the notion of antagonistic subject positions to peace to identify the intersecting relations of power through which groups of population who resist peacebuilding processes are organized and how they can commit to agonistic dialogue.

Keywords: feminist intersectionality,post conflict transition,colombia,agonistic pluralism
Functional connectome of brainstem circuits that control locomotion (LocomotorIntegration)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Sweden,Denmark
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2021-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 1125130.1
Participants: 2
Project status: CLOSED

Locomotion is a complex motor act that is used in many daily life activities and is the output measures of a plethora of brain behaviors. The planning and initiation of locomotion take place in the brain and brainstem, while the execution is accomplished by activity in neuronal networks in the spinal cord itself. Recent experiments have provided significant insight to the organization of the executive spinal locomotor networks. However, little is known about the brainstem control of these networks. Here, I propose to provide a unified understanding of the functional connectome of the key brainstem networks that control locomotion in mammals needed to select appropriate locomotor outputs. To obtain these goals we will develop a suite of transgenic mouse models with optogenetic or chemogenetic switches in defined populations of brainstem neurons combined with the possibility to use state-of-the-art cell-specific electrophysiological and anatomical connectivity studies. We will reveal the functional organization of ‘go’ and ‘stop’ command systems in the brainstem that are directly upstream from the spinal locomotor networks and the mechanisms for how spinal networks are selected. We will further functionally deconstruct the next network layer in midbrain structures that control the ‘go’ and ‘stop’ command systems. Our research takes a specific approach to provide mechanistic insight to the integrated movement function by building the motor matrix in a functional chain from the locomotor–related spinal cord neurons that have been identified to midbrain neurons. A segment of our research will link these networks to locomotor impairments after basal ganglia dysfunction. The work has the potential to make a breakthrough in our understanding of how complex movements are generated by the brain and has translational implications for patients with movement disorders. It will push boundaries in the universal effort that aims to comprehend how brain networks create behaviors.

Keywords: motor control,brainstem,spinal cord,basal ganglia,neurons,optogenetics
Real time Optoelectronic Sensors for Electro-Actuator Hydraulic Fluid Contamination Monitoring (FluidER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Health Monitoring for Electro-Hydraulic Actuator fluid (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-09-30
Duration (months): 30.0
Total project cost (EUR): 560982.5
EU funding (EUR): 498451.25
Participants: 2
Project status: CLOSED

FluidER project aims to deliver fully integrated and autonomous sensor for in-line sensing and diagnosis of aviation hydraulic fluids (HF) used in electro Hydraulic Actuators (EHA). The proposed diagnosis approach is based on the combination of hydraulic fluid physic-chemic parameter sensors and fluid contamination sensors and, with the aim of achieving an early warning of degradation signs, especially in terms of particulate count and water contamination, before the hydraulic fluids exceeds the service limits. The combination of a set of heterogeneous sensor technologies is motivated by the lack of accuracy achieved by single devices, especially when dealing with multi-source contaminations and when an early identification of degradation evidences is targeted. FluidER proposal merges two types of approaches: (i) Sensors delivering measurements of physical and chemical parameters of the Hydraulic Fluid as the Viscosity, Density, Moisture, Dielectric Constant, Colour or Temperature, and (ii) sensors specifically designed to monitorize different contamination sources as the particulate matter concentration, presence of air or water. Specifically, FluidER will address the analysis of physical contaminants (metallic and non-metallic particulate count, air bubbles, etc.) through in-line microscopic imaging and machine vision proprietary techniques. Additionally, chemical contaminants (water content, acidity) will be estimated through VIS-IR spectroscopic inspection and chemometric algorithms. The information obtained from the different sensors will be used to generate a Diagnosis of the status of both, the fluid itself and the EHA equipment, through new health monitoring algorithms. The different hardware and software components included in the FluidER solution will be gradually tested in different test beds, ranging from controlled laboratory hydraulic test beds to a complete EHA test bed and different standardized aircraft tests.

Keywords: in line fluid sensors,condition monitoring,optoelectronic sensors,hydraulic fluids,electro hydraulic actuators,aerospace
PulseHaler: Improving the Lives of COPD Patients (PulseHaler)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Israel
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic obstructive pulmonary disease (COPD) is a group of progressive, debilitating respiratory conditions, including emphysema and chronic bronchitis, characterized by difficulty breathing, lung airflow limitations, cough, and markedly reduced functional capacity. COPD often is associated with a history of cigarette smoking or exposure to pollutants. It kills approximately 270,000 people in the EU annually, equivalent to the size of the entire city of Venice. It affects 4% and 10% of adults in Europe (Halbert et al., 2003). World-wide 5-10% are affected and 3 million die each year (source: WHO). In the developing countries, COPD has been growing dramatically due to increased air pollution, smoking and massive use of biomass fuels for cooking. Respinova has developed a novel non-invasive technology and medical device named the PulseHaler™, that aims to treat the core of the COPD pathophysiology – small airway collapse. The technology was successfully validated in two clinical studies. In the first study, PulseHaler was evaluated for its ability to open small airways. Clinical results demonstrated unprecedented improvements in the 6 minute walk test (6MW), spirometry lung functions tests and in the feeling of dyspnoea. All of these effects were above and beyond the effect of standard pharmaceutical care. In the second study, PulseHaler™ was successfully used as a new means for improved delivery of inhaled drugs to the terminal bronchioles and the alveolar zone in COPD patients. It resulted in three-fold enhancement of penetration index, a measure of efficiency of drug delivery. By improving the drug delivery, PulseHaler technology can enhance efficacy & safety of drug delivery. It can reduce the amount of drug required, ensure less drug goes to non-lung areas (mouth, stomach etc.), and reduce time required to deliver the drugs.

Keywords: pulmonar diseases,respiratory disease,copd,device,innovation
How evaluation shapes ocean science. A multi-scale ethnography of fluid knowledge. (FluidKnowledge)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

New forms of evaluation are reconfiguring science in ways we are only beginning to understand. Through the rich case of ocean science, this project addresses a key challenge in social-scientific research regarding how evaluations are implicated in scientific understandings of the world. Ocean science is increasingly multivalent. Not only is it expected to contribute to a more systemic understanding of the ocean as an ecosystem, it is also called on to analyze environmental effects of climate change, and help fight effects of intensified exploitation. At the same time, it operates in a highly research-focused and efficiency-oriented academic system whose norms partly work against societal relevance. The ambition of FluidKnowledge is to 1) investigate how research agendas are shaped in ocean scientific research; 2) analyze how the value of ocean science is enacted in European and national science policy contexts; 3) develop concepts on the basis of the outcomes of 1) and 2), to theoretically grasp how research evaluation shapes knowledge making. Ocean science provides a planet-critical research site in which to analyze how steering efforts toward interdisciplinary engagement and societal relevance relate to other norms and criteria of scientific quality (e.g. excellence) in actual practice. This project creates a new interface between longitudinal scientometric analysis and rich ethnographic studies. This paves the way for a new interdisciplinary field. A second contribution is conceptual. Whereas many evaluation experts treat the heterogeneity of practice as a problem, I engage such heterogeneity as a resource. The project will build theory that encourages a more comprehensive understanding of how evolving evaluation and knowledge production are mutually implicated. A third novelty is the focus on ocean science. Systematic analysis of its workings and policy implications is crucial for understanding a world in which trust in scientific knowledge is no longer obvious.
“The Emergence of Autonomist Politics: European Radicalism after the Extreme Left, 1976-1985” (AutPo) (AutPo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

“The Emergence of Autonomist Politics: European Radicalism after the Extreme Left, 1976-1985” (AutPo) Abstract This project will produce an original, comparative, and transnational study of the European autonomist movements of the late 1970s and 1980s, the most significant youth movement in the contemporary history of Western Europe after that of 1968. The study will focus on autonomist currents in the major metropolitan centers of Paris, Milan, Rome, Zurich, Frankfurt, and West Berlin, focusing particularly on autonomist ideologies and practices and the response of institutions, including the far left, radical feminist movements, and the state, and on examining issues of protest and political violence. The objectives of the project will be achieved by archival research in both state and social movement archives in France, West Germany, Switzerland, and Italy, including a secondment in Rome, but will also be amplified by the constitution of an oral history interview base and the use of questionnaires informed by the most recent sociological methods. The study is relevant to the MSC-IF program because of the enduring impact of autonomism on radical political culture in Europe and because it will examine dynamics of political violence in protest movements, moving beyond the typical focus of studies of violence in the 1970s on terrorism and armed movements. In so doing, it will facilitate better understanding of the dynamics of violence in contemporary protest by helping to identify the historical transformations of protest cultures and the interactions between protest movements and state institutions in a comparative and transnational lens focused on recent European history.

Keywords: autonomism,political radicalization,protest,violence,governance,1977,transnational and comparative history,oral history
Next generation urban mining - Automated disassembly, separation and recovery of valuable materials from electronic equipment (ADIR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Austria,Germany,Italy,Poland,France
Call: Recovery technologies for metals and other minerals (H2020-SPIRE-2015, 2015)
Start date: 2015-09-01
End date: 2019-12-31
Duration (months): 52.0
Total project cost (EUR): 6244936.59
EU funding (EUR): 5262198.87
Participants: 11
Project status: CLOSED

Specific raw materials become increasingly important to manufacture high level industrial products. Especially electronic equipment contains precious metals and a series of strategic raw materials. To date the material specific recycling is focused on mass stream concepts such as shredder processes and metallurgy to extract the high-value metallic constituents, i.e. copper, gold, silver. However, a series of critical elements cannot be recovered efficiently or is even lost in dust or residual fractions. The goal of ADIR is to demonstrate the feasibility of a key technology for next generation urban mining. An automated disassembly of electronic equipment will be worked out to separate and recover valuable materials. The concept is based on image processing, robotic handling, pulsed power technology, 3D laser measurement, real-time laser material identification (to detect materials), laser processing (to access components, to selectively unsolder these; to cut off parts of a printed circuit board), and automatic separation into different sorting fractions. A machine concept will be worked out being capable to selectively disassemble printed circuit boards and mobile phones with short cycle times to gain sorting fractions containing high amounts of valuable materials. Examples are those materials with high economic importance and significant supply risk such as tantalum, rare earth elements, germanium, cobalt, palladium, gallium and tungsten. A demonstrator will be developed and evaluated in field tests at a recycling company. The obtained sorting fractions will be studied with respect to their further processing and recovery potential for raw materials. Refining companies will define requirements and test the processing of sorting fractions with specific material enrichments. An advisory board will be established incorporating three telecommunication enterprises.

Keywords: urban mining,automatic disassembly,identification and separation,recovery of valuable materials,technology metals,recycling,printed circuit boards,mobile phones,reverse production