Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clean Energy Transition Partnership (CETP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: COFUND actions
Partnership: Clean Energy Transition (co-funded)
Countries involved: Austria,Denmark,Estonia,Greece,Spain,Finland,France,Croatia,Hungary,Ireland,Israel,Iceland,Italy,Lithuania,Latvia,Netherlands,Norway,Belgium,Poland,Portugal,Romania,Sweden,Türkiye,Cyprus,Germany,Switzerland,United Kingdom,Morocco,Czechia,Malta,Tunisia
Call: Clean Energy Transition (HORIZON-CL5-2021-D3-01, 2021)
Start date: 2022-05-01
End date: 2030-12-31
Duration (months): 104.0
Total project cost (EUR): 561150162.21
EU funding (EUR): 136317392.84
Participants: 72
Project status: SIGNED

The Clean Energy Transition Partnership (CETP) is a transnational initiative on joint RTDI programming to boost and accelerate the energy transition, building upon regional and national RTDI funding programmes. It aims to empower the energy transition and contribute to the EU’s goal of becoming the first climate-neutral continent by 2050, by pooling national and regional RDTI funding for a broad variety of technologies and system solutions required to make the transition. It will foster transnational innovation ecosystems from the very local and regional level, up to the transnational European level, thus overcoming a fragmented European landscape. The CETP is aiming to enable 70 national and regional RDTI programme owners and managers from 32 countries to align their priorities and implement annual joint calls from 2022 to 2027 (original first proposal as published by the EC on CORDIS). Actually 30 countries and 55 programme owners and managers formally participate in this Initial Grant Agreement. They also organise joint accompanying activities to enable a dynamic learning process, extract strategic knowledge (“Knowledge Community”) and maximise the impact (“Impact Network”) to accelerate the upscaling, replication and market diffusion of innovative solutions. This will foster the up-take of cost-effective clean energy technologies. The common vision of the CETP is already manifested in its Strategic Research and Innovation Agenda (SRIA) that has been co-created in a broad engagement process during 2020, together with the involved countries, the EU SET-Plan Implementation Workin Groups and ETIPs, all energy relevant ERA-Nets as well as the EERA joint programmes (over 500 editors, co-authors, commenters and discussants). The SRIA was endorsed together with the European Commission (DG RTD and ENER) in November 2020 . This articulates the common goal of (1) building a transnational transformative Joint Programming Platform, (2) developing and demonstrating technology and solutions for the transition of energy systems, and finally (3) building innovation ecosystems that support capacity building at all levels.

Keywords: renewables,energy systems,power systems,ccus,heating and cooling,storage,fuels,integrated regional energy systems,industrial energy systems,building integration
Modelling Enlightenment: Reassembling Networks of Modernity through data-driven research (ModERN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1997183.0
EU funding (EUR): 1997183.0
Participants: 2
Project status: SIGNED

The Enlightenment has long been associated with the rise of modern Europe, and more generally with the concept of a typically European Modernity that took root in its wake. What it means to be ‘modern’ is indelibly bound up with our understanding of the Enlightenment’s core concepts: reason, religious toleration, civic virtue, political liberty, and scientific progress, to name but a few. For some, the Enlightenment is an essentially philosophical matter; for others it was and remains deeply political. Whatever the case may be, one thing is certain: for better or worse, it is widely accepted that the Enlightenment ushered in a new, modern era in both politics and philosophy, beginning in the 1790s and continuing today. The role of 18th-century ideas in this modernising process, and by proxy, the books that came to embody them, has long been the subject of intense scholarly debate, primarily concerned with the social and intellectual causes of the French Revolution. As a result, the field of Enlightenment studies today continues to privilege a relatively small canon of writers—primarily those that participated in the more ‘radical’ strains of Enlightenment thought in France. This is only one version, or vision, of the Enlightenment, however, albeit one that tends to dominate contemporary discourse. This project aims to fundamentally re-evaluate this interpretation of the Enlightenment and its actors by expanding the knowledge base on which these previous claims have been made; not only in terms of the diversity of authors and texts included, but also in the development of new digital techniques for identifying and analysing 18th-century information networks and their subsequent reception. In so doing, ModERN will move Enlightenment studies in a decidedly new direction; one that is both more comprehensive and more systematic in terms of its relationship to the existing digital cultural record, and one that likely challenges subsequent narratives of European Modernity.

Keywords: digital humanities,enlightenment studies,intellectual history,book history
The synaptic active zone as a signaling hub for sleep homeostasis and resilience (SynProtect)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2242580.0
EU funding (EUR): 2242580.0
Participants: 1
Project status: SIGNED

Resilience designates the ability of the brain to cope with and adapt to stressful situations. Sleep homeostasis is tightly linked to resilience, and the sleep deficits observed alongside neurodegeneration probably operate as direct “drivers” of neurodegeneration. However, the knowledge gaps still remain huge and causally bridging the molecular/cellular with the behavioral and organismic level remains a challenge, hampering progress equally for biomedical and basic research. Our recent data suggest that a form of presynaptic active zone plasticity (“PreScale”), widely triggered in sleep-deprived Drosophila brains, can enhance the brain resilience to cope with the adverse effects of sleep deprivation. Concretely, genetically fostering PreScale in sleepless mutants rescued them from their reduced lifetime, stress sensitivity, cognitive deficits and hyperexcitability due to too low levels of voltage-gated potassium channels. In SynProtect, we seek to test our hypothesis that PreScale constitutes a globally-operating homeostatic plasticity mechanism remodeling presynaptic terminals comprehensively to tune resilience states. In order to test this idea, we will elucidate the core molecular scenario executing and bidirectionally regulating PreScale and, consequently, decipher how exactly the remodeling of the mere presynaptic active zones and local excitability tuning via potassium channels intersect at the presynaptic terminal. In parallel, we will test whether PreScale is needed to enhance resilience in a brainwide fashion or if its modus operandi is more local. Genetic manipulation of PreScale will allow us to define brain states of high and low resilience, which we will dissect combining super-resolution and in vivo activity imaging and proteomic tools. Thus, we will open the way towards a comprehensive insight into the activity, signaling and metabolic profile of brain resilience.

Keywords: synaptic plasticity presynaptic active zone super resolution microscopy drosophila resilience sleep homeostasis behavioral genetics synapse proteomics
Nuclear Shapes of Heavy Atoms and Proton-Emitting nuclei (NSHAPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

By combining atomic, nuclear and particle physics techniques, I shall perform the experimental study of the shape of key atomic nuclei, to challenge our understanding of the nucleus. This combined effort will reach unprecedented sensitivity, precision and accuracy to determine the shape observables (charge radii, electric quadrupole moments) and compare them to state-of-the-art nuclear models (spherical shell model, density functional theory, ab initio models based on chiral effective field theory). This programme will combine different techniques at various accelerator facilities where I employ and develop unique approaches and instrumentation: - At CERN ISOLDE (Geneva, CH), high-resolution laser resonance ionization spectroscopy will be performed with the Resonant Ionization Laser Ion Source (RILIS) combined with the Perpendicularly-Illuminated Laser Ion Source and Trap (PI-LIST) to study the onset of octupole deformation and proceed towards the proton drip line with selected nuclei. - At GANIL SPIRAL2 (Caen, FR), high-sensitivity laser resonance ionization spectroscopy will be performed in the supersonic gas jet of the gas cell at the focal plane of the Super Separator Spectrometer (S3) to study the most exotic isotopes not available at ISOLDE, reaching proton-unbound nuclei at the drip line. - At PSI (Villigen, CH), muonic x-ray spectroscopy will be performed on key isotopes to measure absolute charge radii that are crucial to complete the analysis of the NSHAPE isotopes. This work will combine a strong experimental development in target production for muX, in the detector array, and in the analysis tools. Combining the high-resolution laser spectroscopy and the high-accuracy from μx-ray spectroscopy is a unique programme that only NSHAPE can fully realize, providing radii and moments with unprecedented accuracy. From those results, I shall obtain a deeper understanding of the strong interaction at work in the nuclear medium.

Keywords: nuclear shapes,nuclear structure,heavy elements,proton emitting nuclei,laser spectroscopy,muonic atoms
A training network on the design of precision therapeutics that target key glycan motifs implicated in cancer (GlyCanDrug)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Portugal,Spain,Denmark,Slovenia,France,Germany,Netherlands,Hungary,United States,Belgium
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 2696457.6
EU funding (EUR): 2696457.6
Participants: 23
Project status: SIGNED

Glycoscience has gained such significant technological advances over the past decade, that it is now poised for giving an unprecedented contribution to high-demanding societal needs. GlyCanDrug is a glycoscience-oriented DN that aims, for the first time, to take a step ahead in the design of precision therapeutics targeting key glycan motifs implicated in cancer. These glycans are fingerprints of many cancers. Thus, their targeting has the striking potential to overcome cancer heterogeneity that limits the current targeted therapies providing new opportunities for the discovery of precision therapeutics. The credibility and high quality of GlyCanDrug are ensured by top-level glycoscientists from 9 academic institutions (8EU & 1US) and 6 SMEs which encompass complementary and intersectoral expertise, and unique state-of-the-art technological tools to train 10 doctoral candidates (DCs). GlyCanDrug focuses on the precise inhibition of the expression of cancer-associated glycans and the development of cutting-edge tools for their targeting. The unique combination of scientific excellence in interdisciplinary fields and industry know-how will cover the entire process from obtaining fundamental insights to the implementation of innovative solutions. GlyCanDrug aims at creating a critical mass of uniquely skilled graduates in glycan-based therapies. To this aim, we will equip DCs with a thorough multifaceted knowledge of the potential of glycoscience in the discovery of cancer precision therapeutics and the necessary transferable skills. This will put DCs in an advantageous position for job opportunities in both academia and industry. Deciphering the glycome expands the frontiers of knowledge and discovery and enables addressing fundamental challenges in cancer. Therefore, GlyCanDrug DN will strengthen the European innovation capacity by bringing new glycoscience concepts in the development of cancer precision therapeutics to market and policy stakeholders.

Keywords: monoclonal antibodies,glycosyltransferases,inhibitors,cancer glycoforms
The Glucocorticoid Receptor in Aging and Circadian Endocrinology (GRACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1997493.75
EU funding (EUR): 1997493.75
Participants: 2
Project status: SIGNED

The pandemic is stressful for many. In response to stress, glucocorticoids are released. They play essential roles as endogenous hormones and clinically as drugs. High levels are associated with cardiometabolic disorders and with aging. In contrast, diets like caloric restriction ameliorate metabolic dysfunction and prolong lifespan. These diets, however, also increase glucocorticoids. Now the open question is: What are the molecular and physiological effects of increased hormone levels, and are these diets beneficial because or in spite of elevated glucocorticoids? We recently found that nutrition reprograms glucocorticoid responses independently of the hormone level and that diurnal glucocorticoid action controls rhythmic gene expression to regulate circulating glucose and triglycerides during day and night. I hypothesize that the benefits of caloric restriction are due to higher glucocorticoid amplitudes, and that their study will uncover transcriptional features prolonging healthspan. I propose to functionally distinguish between diet-induced positive and stress-induced negative glucocorticoid responses. GRACE will identify diet-specific, ‘rejuvenating’ transcriptional complexes and target genes, versus detrimental pathways triggered by excess glucocorticoids such as stress. Glucocorticoid receptor targets unique to caloric restriction will be determined via ChIP- and RNA-seq in Aim 1. The functional impact of diurnal glucocorticoid release will be dissected with a constitutively active receptor allele in Aim 2. I propose to map active transcriptional regulomes in caloric restriction, in youth and old age, by ChIP-MS in Aim 3. I postulate that enhanced glucocorticoid activity at the right time of day may boost circadian rhythms and promote longevity. Ultimately, applying omics to study the molecular mechanisms of stress hormones will identify pathways and genes amenable to pharmacological or nutritional intervention for longer, healthier lives.

Keywords: glucocorticoids,transcription,genomics,nuclear receptors,caloric restriction,aging,liver
Quantum energy storage and transfer (QUEST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Energy management has always been crucial, throughout history, in advancing technology, enhancing productivity and fostering sustainable development. It is thus not surprising that even now, at the verge of the second quantum revolution, the field of quantum thermodynamics is emerging as one of the most vibrant branches of quantum many-body physics. A key focus of this research area is the conversion of heat, work, and information within quantum systems and, as a consequence, the conceptualization of quantum thermal machines, such as quantum thermal engines, refrigerators, and quantum batteries, which leverage quantum effects like superposition, entanglement, and coherence to extract and transfer energy between quantum systems. Among these, quantum batteries stand out for their potential to achieve faster and more efficient charging processes compared to their classical counterparts, as demonstrated by pioneering studies on the realization of the quantum Dicke battery, which showed a collective speedup of the charging process. These outstanding results have motivated a growing interest towards these quantum technologies. However, despite significant progresses, the field still faces numerous challenges, including stabilization of stored energy, optimization of charging protocols, and enhancement of energy transfer. Within this context, the limitations of current simulation techniques, which often rely on exact diagonalization, restrict the exploration of larger and more complex systems, particularly in higher dimensions. Therefore, as energy management continues to be pivotal in technological advancements and sustainable development, QUEST seeks to address the need for breakthroughs in the development of quantum energy devices, advancing the current state-of-the-art in the field of quantum technologies for energy storage and transfer by developing efficient numerical simulations tools for the design and characterization of many-body quantum batteries.
European Action for Social Entrepreneurship Support (CRAFT)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Belgium,Romania,France,Austria,Latvia,Croatia
Call: Integration of social innovation actors in innovation ecosystems (HORIZON-EIE-2022-CONNECT-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 634047.93
EU funding (EUR): 575789.0
Participants: 9
Project status: SIGNED

Through events, summits, gathering of existing tools for best practice and a digital ecosystem for social entrepreneurs, we will strengthen the ecosystem for social innovation in Europe. We will create a European peer-to-peer academy for social & impact entrepreneurship support. Co-owned by European support organizations, we will endeavor to increase the capacities of social entrepreneurship support organizations in Europe. The academy aims to sustainably boost the impact of the European ecosystem for social & impact-driven entrepreneurship. We will gather and promote tools and facilitate locally based events, and facilitate summits where knowledge, methods, best practices, and tools are disseminated. In addition, we will build on existing digital platforms to create a social innovation ecosystem where best practices, knowledge and tools will be granted free of charge for social entrepreneurs. Key output from the project: - Registration of best practice out before and after intervention. The registration forms from the first registration will be used to select relevant tools to be included in the digital ecosystem. - Two social innovation policy summits and a final conference for actors in the social innovation ecosystem. - Collection of tools from actors working with social innovation. The tools may come from relevant accelerators, investors, incubators and public entities such as universities and government. All activities and tools will be free accessible at the digital ecosystem. The digital ecosystem will be built on existing software systems. The digital ecosystem will be a strong European network with various actors within different branches and knowledge from professionals within the field.

Keywords: intervention,registration,eco innovation