Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tra_Med - patterns of pastoral migrations in the Mediterranean region (TRA_MED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-09-01
End date: 2017-11-01
Duration (months): 24.0
Total project cost (EUR): 187414.8
EU funding (EUR): 187414.8
Participants: 1
Project status: CLOSED

The proposed research addresses an important knowledge gap affecting the scientific as well as the policy making communities in the EU and its neighbours. It looks at the interface between migration dynamics and EU policies on agriculture and rural development, two domains that are raising concern amongst EU public opinion and institutions. While it is recognised that different migrant communities play nowadays an important role in agricultural activities throughout the EU, the implications of this trend are rarely assessed. A better understanding of the dynamics reshaping the EU countryside in socio-economic terms - and specifically the implications of a growing presence of foreign migrants - is needed to inform policy-making accordingly. The research proposes to analyse a specific segment of this domain, that of pastoralism – extensive livestock rearing – which importantly contributes to manage marginal territories and fragile ecosystems, which are of increasing concern for many EU policies. The research hypothesis is that the highly specialised skills of migrant pastoralists are hardly acknowledged by the wider society. The research will look into these dynamics in the Mediterranean region, so to have a coherent and integrated geographical framework. In the last two decades it is mostly young migrants coming from pastoral areas of the Maghreb and the Balkans that are taking over from old shepherds in southern EU countries. The research proposes to assess the patterns of these migrating pastoralists and to critically analyse the underpinning drivers, strategies and networks. Research outcomes will consist of a comprehensive picture of migrants' contribution to sustainable rural development in southern EU, with an analysis of the implications for the whole region. By contributing to disentangle the different aspects of these processes the research aims to contribute to adequately inform policy decision-making at EU level in a number of relevant domains.

Keywords: migration,mediterranean,rural sociology,sustainable agriculture,gender,pastoralism
Hybrid polymer-peptide hydrogels for Cell Therapy (HYCELT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

This project, entitled “Hybrid polymer-peptide hydrogels for Cell Therapy” (HYCELT) will produce cost-effective neuronal stem cell (NSC) scaffolds for central nervous system regeneration using a fibrous gel that has all the necessary requisites for fast clinical translation: cell-instructive, biocompatible, injectable and biodegradable. Finding a perfect methodology to heal spinal cord damage is a challenge of current times. Peptides are used for this purpose because they are biocompatible, biodegradable and will produce suitable gelatinous environments for cell growth at extremely low concentrations. The target of HYCELT is to demonstrate this technology in vitro, with follow-on work focussed on in vivo studies in appropriate animal models and in collaboration with clinical scientists to produce a global therapy that will change the lives of thousands of people suffering from irreparable spinal cord injury. HYCELT brings together a talented young fellow with a background in polymer hydrogels with an internationally blossoming group in polymer nanotechnology and well-established UK groups in peptide/materials science and biomaterials. HYCELTs multidisciplinary solution will exploit polymer-peptide hydrogel system also be applied in the vast field of drug delivery. Moreover as it will be developed in concert with Merck Serono (Italy), the biotechnology world-leaders in the field of therapeutics, it will be immediately applicable to living system. The supervisory team has been selected from experts at Aston, Sheffield and Merck (Rome) to provide a multidisciplinary training programme for the fellow and to ensure success of the ambitious research targets of HYCELT.

Keywords: peptide,polymer,hydrogel,injectable,cell scaffold
In the frame of party competition: citizenship, voting rights and nation-building in the post-Yugoslav space (COMPCITXU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 179739.6
EU funding (EUR): 179739.6
Participants: 1
Project status: CLOSED

The conflict in the post-Yugoslav space has been given considerable scholarly attention. Yet, many political processes in these states, deeply affected by the dynamics of EU accession and membership, have been neglected by the mainstream political science. Having this analytical gap in mind, this cross-disciplinary Marie Curie project analyses the effects of party competition on the relationship between citizenship and voting rights in post-Yugoslav countries with consolidated (Slovenia, Croatia, Serbia, Kosovo) and conflictual (Bosnia and Herzegovina, Macedonia, Montenegro) politics of national identity. Conceptually, it first challenges Kitschelt’s (1997) paradigm for understanding party competition in post-communist countries, as it is inapplicable in polities that have undergone both partition and conflict. In addition, by studying the link between the transformations of citizenship and voting rights in the context of party competition, the project adds to Brubaker’s (1992) observations that the image of politics captured in the underlying legislation is not only ideal but also practical. Empirically, by tracing processes of change in citizenship and franchise legislation, it complements the existing research on the policy output in Europe’s new states. Through its key aims, the project thus has relevance for three research priorities outlined in the 2012 Work Programme. It explores how the different countries define 'insiders' and 'outsiders' in their political spaces, and helps to unveil major trends in society and their implications. Moreover, it looks at how the interplay between citizenship and franchise is changed and shaped by party competition in post-Yugoslav space, and contributes to the understanding of Europe’s role in its neighbourhood, and the broader issues related to citizens in the EU and its immediate surroundings.

Keywords: s109 political systems - legitimacy of governance,s107 transformation of societies - democratization - social movements,citizenship,voting rights,party competition,former yugoslavia
An investigation into the differential mechanisms and regulation of leukocyte clearance from the human lung across two distinct barriers: the bronchial epithelium versus the alveolar epithelium (LUNG INFLAMMATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-02
End date: 2015-09-01
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Inflammation of the lung is central to the pathogenesis of most respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), cystic fibrosis (CF) and pneumonia. Leukocytes traffic through normal lung for immune surveillance; but these numbers increase in response to toxins or pathogens and can be overwhelming. Leukocytes can exit from the lung interstitium across the bronchial epithelium, into the airway lumen by a mechanism called “luminal clearance”. This mechanism is dependent on the co-ordinated leukocyte adhesion to sequential epithelial cell surface molecules and prevent excessive airway inflammation. In contrast, migration of leukocytes across the alveolar epithelium is hazardous. Leukocyte migration into the alveolar space underlies the pathogenesis of lung diseases such as pneumonia and PF. However, despite their importance very little is known of these two distinct trans-epithelial pathways. This project will examine the distinc regulation of leukocyte clearance across these two epithelial barriers (bronchial and alveolar) using a novel in vitro human model system. This work will then be extended to animal models of human disease, and in particular a murine model of PF, well established at UCL. Finally, confirmatory findings will be sought in human patient studies. An IEF will allow Dr Rebeyrol to bring her expertise on lung epithelial inflammation gained during her studies in CF, to our UCL laboratory, and she will, in turn, acquire a working knowledge of in vitro and in vivo models of leukocyte migration in the healthy and diseased lung. An IEF will be central to her developing the foundation to establish her own laboratory to continue important work into novel therapies for CF and other inflammatory lung diseases.

Keywords: lung - pulmonary diseases - resolution of inflammation - bronchial and alveolar epithelia - neutrophils - adhesion molecules - transepithelial migration - copd - cystic fibrosis - pulmonary fibrosis
Flavour Violation in Supersymmetric Extensions of the Standard Model (SUSYFLAVOUR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

This research belongs to the field of theoretical flavour physics, which is a branch of particle physics. It is carried out as a 2-year fellowship in the Theory group of European Organization for Nuclear Research (CERN) in Geneva, Switzerland. The standard model of particles physics (SM) describes three fundamental interactions acting between the fundamental constituents of matter, the quarks and leptons. The matter particles, distinguished by their `flavour' quantum number are grouped into three different generations. Flavour physics studies the transitions between these three generations. In the current LHC era the focus of particle physics is the discovery of new laws of physics beyond the SM. Since flavour changes are highly suppressed in the SM, flavour physics is an excellent tool to probe this new physics. Recently observed anomalies in B physics (Bs mixing, Bs->mumu and B->tau nu) and in the anomalous magnetic moment of the muon challenge the SM and call for an explanation in models of new physics. Together with the high energy results from the LHC, these decays can help to clarify which model of new physics could lie beyond the SM. SUSYFLAVOUR focuses on flavour-changing effects in the minimal supersymmetric standard model (MSSM) which is the best motivated extension of the SM. The MSSM possesses many new sources of flavour and CP violation stemming from the supersymmetry-breaking sector. A lot of theoretical effort is devoted to the understanding of the mechanism governing the flavour structure of these supersymmetry-breaking terms. The research pursues several avenues to map out this structure. All lines of research will be phenomenology-driven, using the upcoming data from the CERN experiment LHCb, Atlas and CMS.

Keywords: p102 particle physics,p101 fundamental interactions and fields
Ultrafast dynamics of chemical reactions in solution (MPGMC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The field of gas-phase reaction dynamics is well developed, facilitated by a vast array of sophisticated experimental and theoretical techniques. Gas-phase studies have proved vital for developing our understanding of chemical reactivity, but most reactions in nature and practical chemical synthesis occur in the liquid phase. Reaction dynamics in the liquid phase are far less understood, but recent improvements in ultrafast laser technology now make the kinds of time-dependent study required to probe such dynamics possible. Interactions with solvent molecules may, for example, alter the relative energies of reactants and products, or affect the stability of intermediate structures, and dampen their motion through solvent friction. MPGMC seeks to quantify such effects, and establish ‘rules’ that describe the effects of solvent on a chemical reaction by comparative studies in the gas and liquid phases. The Bristol group has acquired a state-of-the art, ultrafast laser system for probing liquid phase reactions in real time using transient pump/probe IR and UV spectrometry. Photodissociative and bimolecular reactions will be studied, in a range of solvents, and the results compared to those from previous and on-going gas-phase studies of the same reactions. By observing the evolving electronic state populations (in the parent and products), and/or active vibrational modes in the products, mode-specific dynamics can be extracted and conclusions drawn about the transition state structure and the solvent’s effect on the reaction-path. The time-dependence of the absorption spectra also provides insights into the way product internal motions couple to the degrees of freedom of the solvent bath (distinguishing, for example, interactions within the initial solvent cage and those occurring after the products diffuse into the bulk solvent). In this way, MPGMC seeks to provide a molecular level understanding of the effect of solvent on reaction mechanisms.

Keywords: c101 physical chemistry,c103 spectroscopic and spectrometric techniques,c107 chemical physics,ultrafast,solvent effects,reaction dynamics in liquids
Evaluation of the synergy between tamoxifen chemotherapy and hypericin photodynamic action, following mitochondrial complex III photo-inhibition: Towards a combinatorial anticancer treatment modality (HYPERTAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-07
End date: 2015-07-22
Duration (months): 24.0
Total project cost (EUR): 301250.6
EU funding (EUR): 301250.6
Participants: 1
Project status: CLOSED

In the present Marie Curie Intra European Fellowship application, HYPERTAM, we propose to combine our recent complementary findings in two separate anticancer therapeutic modalities, namely, photodynamic therapy of cancer (PDT) with hypericin or other phototoxins and tamoxifen chemotherapy, fusing them in one combinatorial treatment predicted to demonstrate enhanced antitumoural potency through synergy of tamoxifen action with hypericin photo-inactivation (inhibition) of mitochondrial complex III quinoloxidizing centre. The main points to be addressed by HYPERTAM are summarized as follows: (i) Revisit and expound the tamoxifen - complex III inhibitor cytotoxic interplay findings. (ii) Explore the predicted hypericin PDT-tamoxifen synergistic action in selected cell models. (iii) Evaluate other photosensitizers with high clinical relevance. (iv) Investigate the cell death pathways implicated in the most striking in-vitro results (v) translate the most important in-vitro combinatorial treatment results to corresponding animal models for a pilot preclinical assessment. The fellowship is expected give the applicant a unique opportunity to acquire key skills and knowledge like: (i) competences in molecular biology including evaluation of cell death mechanisms and pathways (ii) competencies in the use of novel lab techniques and instrumentation (iii) certified competencies in animal tumour models. (iv) competencies in management, administration and entrepreneurial activities. The possibility to run HYPERTAM represents a unique opportunity for the applicant to perfect his professional profile, and at a very critical juncture, steer his career towards independent research. The expected result of the proposed project, a cross-disciplinary bimodal anticancer treatment modality with high potency, is of high socioeconomic value, and is expected to greatly contribute to European excellence and competitiveness.

Keywords: photodynamic therapy,chemotherapy,lif,tamoxifen,hypericin,photosensitizers,mitochondria,complex iii,quinoloxidizing centre,combinatorial treatments,cell death,cells,animal models.
Novel Delivery Platform for Hydrophobic Drugs ("RTILS-GELS")

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-01-15
End date: 2016-01-14
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Underpinned by pharmaceutical-industry estimates that approximately 40% of lipophilic therapeutic molecules are rejected because of their poor aqueous solubility and formulation-stability issues, one of the main challenges facing modern pharmaceutical science is the development of carrier vehicles for the extended delivery of such drug candidates. Additional impetus for such research activities is provided by the potential of such carriers to improve the therapeutic profiles of many of the widely used hydrophobic chemotherapeutants. Nowday, carrier vehicles for the delivery of hydrophobic drugs are associated with several disadvantages: conventional emulsions, micelles and liposomes are thermodynamically unstable; lipophilic carriers cluster in blood flow and are rapidly opsonized and massively cleared by liver and spleen; loading capacity of hydrophobic drugs into hydrophilic carriers is limited. Rationalised in the terms of thermodynamic stability, capability to move through blood capillaries, imrpoved drug loading capacity, surface-charged hydrophilicity, and capacity to effect controlled drug release, one of the approaches towards addressing these issues involves the use of superabsorbent polyelectrolytes-based nanogels with affinity for both water and organic liquids. Towards the development of biomaterials for the delivery of hydrophobic drugs, in this project, biocompatible, polymerisable Room Temperature Ionic Liquids (RTILs) based on 1-vinylimidazole and amino acids, as well as nanoparticulate co-polymeric gels of the same RTILs and 2-hydroxyethyl methacrylate (HEMA)/1-vinyl-2-pyrrolidone (NVP) with superabsorbency for both water and several organic liquids will be synthesized and characterised. The suitability of the nanogels to be a novel delivery platform for hydrophobic/aqueously unstable drugs will be assessed in vitro in the terms of biocompatibility, drug uploading and release profiles.

Keywords: c129 biomaterials synthesis,c128 nanomaterials,c125 ionic liquids
Novel Alpha-Helix Mimetics as Anti-Cancer Leads (NHELMIMACANL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-06
End date: 2016-01-05
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer in women in the western world, and 80% of breast cancers express the estrogen receptor (ER). Whilst inhibitors of ER action such as Tamoxifen and inhibitors of estrogen biosynthesis (e.g. aromatase inhibitors such as Anastrozole) have contributed to reductions in breast cancer mortality, resistance to these agents is a major problem. Such resistance could potentially be minimised by switching therapy with endocrine agents and as such there is an urgent clinical need to identify potent inhibitors of novel targets focused on countering endocrine resistance. Liver receptor homologue 1 (LRH-1) is a nuclear receptor (NR) protein whose transcriptional activity is critical for aromatase expression in tissue surrounding the tumour. Moreover, LRH-1 also directly regulates breast cancer cell growth acting in concert with ER. Development of selective LRH-1 inhibitors would therefore provide a potent means of inhibiting ER activity in breast cancer cells, by direct down-regulation of ER levels and prevention of its activation by inhibiting local estrogen biosynthesis. In this project, we plan to develop selective LRH-1 inhibitors by synthesising small molecule Coactivator Binding Inhibitors (CBIs) that will block the protein-protein interaction between LRH-1 and its coactivator proteins (e.g. SHP-1). This interaction is an obligatory prerequisite for transcriptional activity. The critical binding interface comprises an alpha-helical secondary structural motif presented on the surface of the coactivator and a complimentary surface exposed groove in the AF-2 domain of LRH-1. Five key residues on the alpha-helix are required for potent and selective binding. Thus the molecules we will prepare by organic synthesis and evaluate initially in both FRET binding and cell-based gene-reporter assays as LRH-1 antagonists will comprise of structurally novel 5-residue-presenting alpha-helix mimetics.

Keywords: c111 method development in chemistry,c134 biological chemistry,c141 organic chemistry