Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of membrane potential Instabilities in Irritable Bowel Dysease (RIIBS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders with a prevalence of 4-10% worldwide, characterized by recurrent abdominal pain. Pain is tightly related with noxious stimulus detection carried out by peripheral sensory neurons (PSNs). However, how those neurons generate ongoing activity, encoding constant or slow stimuli is still uncertain, and the current textbook model for sensory transduction and encoding fails to explain it. During the last years, many authors have proposed membrane potential instabilities (MPIs), a voltage dependent phenomenon that consists in subthreshold membrane potential fluctuations, as the mechanism underlying ongoing activity and demonstrated its upregulation in pathologies coursing with neuropathic and bone cancer pain, both in animal models and patients. Nevertheless, the role of MPIs in visceral pain remains completely unexplored. In this project we aim to characterize the role of MPIs and excitability changes in the development of IBS pain, as well as its underlying mechanisms. Furthermore, we will develop a new model to study the subcellular distribution of MPIs and action potential encoding in this pathology, using voltage optical recordings. Finally, to assure the translatability of our results, we will study sensory neurons from IBS patients and the possibility to treat them through MPIs pharmacological disruption, opening new treatment approaches. In the long-term, RIIBS action will lead to increased insight in sensory information encoding, the pathophysiology of IBS and ultimately to improved clinical management of visceral pain. This is the adequate moment to carry this action, as the host institution counts with top-notch facilities to make it feasible, the host supervisors have recently generated a novel animal model reproducing IBS and have access to clinical patients, and voltage optical recordings have been living an exponential refinement in the last years.

Keywords: visceral pain,irritable bowel disease,optical voltage recording,intracellular recording,action potential firing,membrane potential instabilities
Building REsilience against MEntal illness during ENDocrine-sensitive life stages (Re-MEND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Sweden,Germany,Italy,United States,Bangladesh,United Kingdom,Finland,Portugal
Call: Towards a molecular and neurobiological understanding of mental health and mental illness for the benefit of citizens and patients (HORIZON-HLTH-2021-STAYHLTH-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 10868225.26
EU funding (EUR): 10868221.25
Participants: 18
Project status: SIGNED

Mental illnesses represent a huge burden for society, the economy, and the aMental illnesses represent a huge burden for society, the economy, and the affected individuals. To significantly increase citizens? mental health, today?s symptom-based diagnoses need to be complemented by biological criteria accounting for individual and sex differences. Furthermore, early detection and prevention measures need to be improved. RE-MEND addresses the current gaps and challenges with an interdisciplinary approach by: i) focussing on four critical life stages in which an individual?s susceptibility to mental illness is strongly influenced by changes in endocrine signalling, including sex hormones, namely early life, puberty, peripartum, and transition into old age; ii) integrating data from large population-based longitudinal cohort studies allowing for discovery of risk and protective factors as well as biological patterns that influence mental states in the general population across these life stages; iii) complementing epidemiological with experimental studies to establish correlative and causative links leading to mechanistic understanding; iv) using advanced biostatistics as well as machine learning and artificial intelligence for data integration and biomarker and drug target discovery; v) combining the biological approaches with communication science studies to efficiently translate its results to societal impact. Ultemately, RE-MEND will result in: i) Significantly increased mental health literacy among stakeholders and citizens; ii) Validated biomarkers for assessing mental health state and its predisposition as well as more accurate diagnoses and personalised preventive and therapeutic measures; iii) Recommendations for early detection, better prevention, and drug design strategies to protect vulnerable individuals from mental illness in sensitive life stages; and iv) strategies on how these advances can be used to decrease stigma and increase prevention behaviour.

Keywords: endocrine signalling,gene environment interaction,population based data,brain organoids,multi omics,artificial intelligence,drug repurposing,mental health literacy,stigma,depression,anxiety
Journal Poetics - Literature and Media in the Age of Goethe (Journal Poetics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Austria,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: CLOSED

"Journal Poetics – Literature and Media in the Age of Goethe" Historians of literature consider the so-called Age of Goethe (“Goethezeit”) (ca.1770–ca.1830) an era of male highbrow literature following the idea of the autonomy of art. The project aims at broadening of this perspective. The key to this reassessment is the media of the epoch: the journal became the principal literary medium from the 1770s onwards. The project focusses on three main aspects: (1) a broadening of the concept of literature to include journal literature, thus enabling a consideration of works beyond book publications, (2) a broadening of the circle of authors, since many authors of the time - especially female authors - published precisely in periodicals, and (3) a relativisation of the distinction between Highbrow and Popular Culture in the Age of Goethe. Combining literary history with Periodical and Gender Studies, the project will examine these aspects by developing a new heuristic concept: “Journal Poetics”. The results will be a literary-historical monograph offering a first systematic and in-depth investigation of the subject and a website (FEMJOUR) that address a broader audience providing data and information on the topic. The University of Verona with its research focus, its infrastructure and experience in conducting international fellowships is the ideal location for this two-year interdisciplinary project. The supervisor, Prof. Laura Anna Macor, is an expert on the research topic and a former Marie Sklodowska-Curie fellow. Secondments at the Universities of Queen Mary London (Prof. Dr. Görner) and Vienna (Prof. Dr. Norbert Christian Wolf) complement the fellowship.

Keywords: age of goethe,german literature,schiller,journals,periodical studies,female writer,popular culture
Impact Monitor (Impact Monitor)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Germany,France,Netherlands,Italy,United Kingdom,Belgium,Greece,Spain
Call: European Aviation Research Policy in support to EU policies and initiatives (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 2247520.0
EU funding (EUR): 2247519.75
Participants: 11
Project status: CLOSED

Impact Monitor is a proposal to deliver a coherent and holistic framework and toolbox that aim to become the reference choice for technology and policy assessment of the environmental-, economic- and societal-impact of European aviation R&I. Bolstered by its profound knowledge and multidisciplinary expertise, a consortium consisting of 10 research establishments and academic institutes develop this framework and toolbox by advancing credible and successfully-applied approaches beyond state of the art. In particular, Impact Monitor rests on and advances the approaches used in EC Better Regulation guidelines and toolbox and in the EC projects TEAM_Play, Clean Sky TE, and AGILE/AGILE 4.0. Further, capabilities of the framework and toolbox are demonstrated through three use cases addressing exemplary innovations in European aviation R&I, and are made accessible to educate students and broader community via “Impact Monitor Academy”.

Keywords: aircraft design,impact assessment,randi initiatives,clean sky,digitalization
NetworkNature+ - Scaling up nature-based solutions to achieve 2030 policy goals (NetworkNaturePLUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Coordination and support actions
Countries involved: Germany,Belgium,France,Ireland,Netherlands,United Kingdom
Call: Network for nature: multi-stakeholder dialogue platform to promote nature-based solutions (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2023-08-01
End date: 2027-07-31
Duration (months): 48.0
Total project cost (EUR): 5165041.25
EU funding (EUR): 5165041.0
Participants: 11
Project status: SIGNED

NetworkNature+ will continue NetworkNature’s legacy as a ‘network of networks’ and expand it to engage new audiences in addressing the societal challenges outlined by the EU. It will maintain and enhance the established evidence/demand/policy-driven multi-stakeholder platform for NBS, strengthening partnerships and fostering new relationships around a clear strategic framework for action, underpinned by an updated EU Research & Innovation NBS Roadmap and complementary analysis of policy opportunities for integrating NBS at EU, Member State, regional and local level in view of EU 2030 policy targets and EU Missions. NetworkNature+ will provide scientific NBS insights across selected policy priorities and different European and international contexts. This will guide our work around dialogue, stakeholder interactions, knowledge sharing and awareness raising, resulting in products, standards and advisory services that support the growing NBS community of innovators, practitioners and developers. A targeted training and capacity building programme will promote a step change from siloed, project-based thinking towards an integrated, systemic and stakeholder-led approach to NBS planning, design and investment, while leveraging the role of ecosystems as critical infrastructure that support regenerative economic activities and help reduce biodiversity loss. We will enable regional and Europe-wide transdisciplinary collaboration to answer identified R&I needs for NBS via knowledge exchange between EU-funded NBS R&I projects and stakeholders, together with skills development and capacity building for target groups from science, policy, business and society. International collaboration with key strategic partners (e.g. UNCBD, IPBES, IPCC, UNFCCC, UNEP, UNDRR) and selected regions will enable European expertise to inform the global NBS discourse, contributing to the EC’s vision of “a stronger Europe in the world” and supporting new investments for NBS.

Keywords: sustainable development
Dynamical Recurrent Visual Perceiver (DRVis)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Real-life applications of computer vision often require high-quality visual sensors. With current technology, such sensors are expensive. Empirical evidence from our ERC-funded research of biological vision suggests that eye motion enhances recognition capabilities beyond what could be expected if the eye was functioning as a static camera. Motivated by these findings, here we aim to perform the major computer vision tasks required for many real-life applications, including segmentation, classification and identification, with low-resolution cameras. The idea is to use a series of low-resolution frames from a moving camera, rather than using a single high-resolution image. This novel algorithm, termed here DRVis, can be implemented in software or hardware. Unlike existing solutions that use multiple frames to reconstruct a high resolution image from low resolution ones, DRVis does not need to learn all the particularities needed for reconstruction; instead, it focuses on extracting the necessary features per the given task. The goals of the PoC project are to scale up and diversify our current software system, implement the system in hardware and demonstrate its performance in field conditions and develop the IPR strategy and explore the commercialization potential of our solution. We expect it will be applicable to a wide spectrum of image processing tasks in settings where sensor quality is low but multiple time samples are available including smart agriculture, drone navigation and visual aid devices.
Dynamic Megabar Chemistry (MEGACHEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1998106.0
EU funding (EUR): 1998106.0
Participants: 1
Project status: SIGNED

Pressures above 1 Mbar, equivalent to energy densities stored in chemical bonds, are predicted to severely reshape the periodic table of the elements as we know it. Such extreme conditions can radically alter the electronic structure and chemical properties of materials, especially when heating these to temperatures of several thousand kelvins, which suggests new approaches for the synthesis of so-far unknown material structures and compounds. However, due to a lack of predictive modelling and experimental challenges, exploration and exploitation of new chemistry above one megabar has remained a dark spot in our understanding of matter. Unprecedented experimental capabilities provided by large-scale laser facilities and X-ray free electron lasers, also supported by new theoretical and computational tools, now drastically change this situation and I am at the forefront of these revolutionary developments. With MEGACHEM, I will establish the research direction of dynamic megabar chemistry, motivated by my pioneering studies on light elements mixtures. Performing exploratory experiments in close interplay with theory, I will investigate novel routes to two interlinked “holy grail” cases: a) the synthesis of the long sought but still speculative BC-8 structure of carbon and b) a new approach to an efficient formation of ultrasmall nanodiamonds of tailored size and dopant level. Indeed, for reaching both goals, the pressure-driven insulator-metal transition of liquid hydrogen may play a central role. By investigating these cases, MEGACHEM will cover new ground and test state-of-the-art theoretical models by combining studies at my university labs with experiments at large-scale research infrastructures: hard X-ray free electron lasers such as the European XFEL, and the largest optical laser systems, such as the National Ignition Facility and the Extreme Light Infrastructure. By doing so, MEGACHEM can impact various areas, ranging from astrophysics to photocatalysis.

Keywords: high pressure,high temperature,shock compression,x ray free electron lasers,high energy lasers,carbon phase diagram,nanodiamonds
Reinventing the Theory of Machine Learning on Graphs (MALAGA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1479643.0
EU funding (EUR): 1479643.0
Participants: 1
Project status: SIGNED

In many scientic domains, graphs are the objects of choice to represent structured data: from molecules to social networks, power grids, the internet, and so on. The exploitation of graph data represents a major scientic and industrial challenge. Graph Machine Learning (GML) is thus a fast-growing eld, with so-called Graph Neural Networks (GNN) at the forefront. However, in sharp contrast with traditional ML, the eld of GML has somewhat jumped from early methods to deep learning, without the decades-long development of well- established notions to compare, analyze and improve algorithms. As a result, 1) GNNs, all based on the so-called message-passing paradigm, have signicant limitations both practical and theoretical, and it is not clear how to address them, and 2) GNNs do not take into account the specicities of graphs coming from domains as dierent as biology or the social sciences. Thus, practical results may vary wildly from one case to the other, with no guidelines on how to design reliable GNNs in each case. Overall, these are the symptoms of an overlooked major issue: GML is hitting a glass ceiling due to its severe lack of a grand, foundational theory. The ambition of project MALAGA is to develop such a theory. Solving the crucial limitations of the current theory is highly challenging: current mathematical tools cannot analyze the learning capabilities of GML methods in a unied way, existing statistical graph models do not faithfully represent the many characteristics of modern graph data, computational complexity becomes problematic on large graphs. MALAGA will develop a radically new understanding of GML problems, and of the strengths and limitations of a large panel of algorithms. Our goal is to signicantly boost the performance, reliability and adaptivity of GNNs, with a signicant impact on three types of graph data that exhibit very dierent but representative behaviors: biological networks, social networks, and online recommender systems.

Keywords: graph machine learning graph neural networks random graphs theory
Community-based engagement and intervenTions to stem the spread of antimicrobial resistance in the aqUatic environments catalysed by cLImate change and Plastic pollution interactions (TULIP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Philippines,Monaco,Netherlands,Italy,Spain
Call: Planetary health: understanding the links between environmental degradation and health impacts (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2024-01-01
End date: 2028-06-30
Duration (months): 54.0
Total project cost (EUR): 6283534.25
EU funding (EUR): 6283534.0
Participants: 11
Project status: SIGNED

Interconnections between ecological and societal systems facilitate compounding impacts of climate change, environmental plastic pollution and proliferation of antimicrobial resistance (AMR) on the health of people, animals and ecosystems on a planetary scale. Current knowledge on interactions between these three crises in the Earth’s natural systems and their impact on health is highly restricted. TULIP will apply a transdisciplinary socio-ecological systems thinking approach, robust environmental science methods, epidemiology, modelling, sampling design and state-of-the-art molecular tools to generate scientific evidence on plastic-AMR interactions. It will describe spatio-temporal dynamics and patterns of plastic-associated AMR under a changing climate and the compounding health and ecological impacts. It will employ the methodology of intervention and social sciences to explore social driving factors and current policies and design and evaluate community-based interventions and nature-based solutions. TULIP will convert created evidence to modelling-based decision-supporting tools that approximate co-benefits to human and ecosystem health, indicators and environmental policy recommendations highlighting triple-win solutions and foster the science-policy translation using an integrated knowledge translation framework. Aiming to ignite a lasting societal change toward health-promoting environments, TULIP will engage communities, citizen scientists, policymakers and experts from multiple sectors in research, co-design, co-implementation, communication and dissemination processes. TULIP will focus on aquatic environments as they create a milieu for interactions, transport pathways and exposure interface and showcase its approach in the Philippines and Italy and translate to a pan-European scale.

Keywords: amr,plastic pollution,climate change,ocean health,one health,hydrology,aquatic ecology,interventions,social sciences,policy,citizen science