Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ADvanced Reactor Initiative And Network Arrangement (ADRIANA)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Coordination and support actions
Countries involved: Czechia,France,Italy,Germany,Belgium,Hungary,Germany,Romania,France,European organisations area,Netherlands,Slovakia,Latvia
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-02-01
End date: 2011-07-31
Duration (months): 18.0
Total project cost (EUR): 1429911.2
EU funding (EUR): 992650.0
Participants: 15
Project status: CLOSED

The coordinating action ADRIANA (ADvanced Reactor Initiative And Network Arrangement) is proposed to setting up the network dedicated to the construction and operation of research infrastructures in support of developments for the European Industrial Initiative for sustainable nuclear fission. The project as the base for the current long-term taking place coordination activities of Euroatom under financial support of the European Commission for construction of research infrastructure in the frame of Structural funds of the European Union suggests the program of utilization of built-up facilities for the given purpose. The project for this purpose defines in detail the new needed research infrastructures, defines and provides legal and financial structures for major refurbishment or upgrading of existing facilities, the construction of new ones and considers the trans-national access to these experimental facilities. Assurance of long-term reliable and competitive energy resources has been an indispensable request for sustainable development of EU communities and their competition’s positions in the frame of the worldwide economic development and political influence in the process of global governance. The Project solves the above given objectives for reactor systems and connecting technologies: · Sodium Fast Reactor (SFR) · Lead Fast Reactor (LFR) · Gas Fast Reactor (GFR, including very high temperature technologies) · Instrumentation, diagnostics and experimental devices · Irradiation facilities and hot laboratories · Zero power reactors · Road map of research infrastructures.

Keywords: demonstrator,diagnostics,experimental reactor,fast neutron,framework programme,gas cooled reactor,hot cells,instrumentation,integration,irradiation,knowledge dissemination,lead cooled react
Containment thermal-hydraulics of current and future LWRs for severe accident management (ERCOSAM)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Cooperation with Third Countries
Destination: Cooperation with Third Countries
Action type: Collaborative project
Countries involved: Switzerland,France,France,Germany,Netherlands,Canada,Germany,United States
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 3056625.3
EU funding (EUR): 1000000.0
Participants: 8
Project status: CLOSED

The presence of a stratification in a NPP containment is a source of concern, as pockets of hydrogen in high concentration could lead to a deflagration or detonation risk. The objectives of the project are two folds: one is to establish whether in a test sequence representative of a severe accident in a LWR a hydrogen (helium) stratification can be established during part of the transient starting from the initiation of the loss of coolant accident (LOCA) blowdown until the end of bulk hydrogen release from the reactor vessel into the containment, and the second is how this stratification can be broken down by the operation of Severe Accident Management systems (SAMs); sprays, coolers and Passive Auto-catalytic Recombiners. Experiments will be performed in the “smaller scale” TOSQAN (IRSN, Saclay), "medium scale" in the MISTRA (CEA, Saclay) and PANDA (PSI, Villigen) facilities. The specifications of the counterpart tests to be designed for the desired tests in the KMS facility (NITI, St Petersburg) will provide basis for code benchmarking at "nearly prototypical scale”. State of art tools, lump parameter to CFD codes, are planned for pre- and post-test calculations and scenario analyses. A synthesis report to be produced will integrate the outcome of test results from the facilities as well as the code analysis in view of highlighting the anticipated behaviour in a LWR and point out to strengths and deficiencies in the predictive capabilities of the tools. To be coupled at the technical and administrative levels, the research will be conducted by two parallel running projects. One project consortium is composed of PSI (Switzerland), IRSN and CEA (France), KIT (Germany), NRG (The Netherlands) and AECL (Canada) and the second project to be run by the Russian organizations: IBRAE, SPbAEP, IPPE, and NITI (the Russian Federation). These two strongly interlinked and coordinated research projects will foster cooperation and provide means to reach a common safety goal.

Keywords: hydrogen,mixing,distribution,stratification,break-up,containment,lwr,sprays,coolers,par
Role of Quorum Sensing mechanisms in the Immune System s regulation (QSIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2105950.0
EU funding (EUR): 2105950.0
Participants: 1
Project status: CLOSED

The homeostatic control of lymphocyte numbers provides the immune system with a basic mechanism that shapes the repertoire of the immune-competent cells and therefore, the capacity to respond to exogenous antigens as well as to maintain self-tolerance. Homeostatic mechanisms will also enable the re-establishment of the immune system following disruption (irradiation or chemotherapy). During the process of restoration, the immune system can be reset at a new equilibrium overcoming any of its previous malfunctions. This capacity of homeostatic regulation may therefore be used in potential therapeutic strategies to radically modify lymphocyte repertoires, immune responses, autoimmune disease and allergy. We now postulate that control of lymphocyte numbers may be achieved by the ability of lymphocytes to perceive the density of their own populations. Lymphocytes may use quorum-sensing mechanisms to coordinate their gene expression according to the density of their population, as long as lymphocytes have (a) a mean of assessing the number of components they interact with and (b) a standard response once a threshold number of components is detected. To address the role of quorum-sensing in the Immune System this project aims: 1) To study the role of quorum-sensing mechanisms in the homeostasis of natural activated IgM-secreting and memory B cell populations, by studying the role of secreted IgG in these processes. 2) To determine the role of quorum-sensing mechanisms associated with the homeostasis of naïve and regulatory CD4+ T cells, by studying the role of IL-2 titers in T cell homeostasis. This project has a major potential impact in medical care, addresses new lines of research and uses original experimental strategies and models that we devised in the laboratory.

Keywords: immune system homeostasis
Meeting the Materials and Manufacturing Challenge for Ultra High Efficiency PF Power Plants with CCS (NEXTGENPOWER)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Clean coal technologies
Action type: Collaborative project
Countries involved: Netherlands,United Kingdom,United Kingdom,Switzerland,United Kingdom,France,Finland,Slovakia,Germany,Czechia,Netherlands,United Kingdom,Germany,United Kingdom
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 10262367.76
EU funding (EUR): 5996880.0
Participants: 15
Project status: CLOSED

Carbon Capture and Sequestration has become an important technology to comply with the CO2 reduction targets set by the EC. However CCS has the drawback that the electrical efficiency of the coal fired power plant will drop significantly. To overcome this drawback, one has to increase the base efficiency of the power plant or increase the biomass co-firing share as this is a CO2 neutral energy source. Increasing the base efficiency of new plants or increasing the share of biomass are both limited due to quality of the present available coatings and materials. The presently used materials in the boiler, interconnecting pipework and steam turbine can not withstand operating temperatures higher than 620°C. Live steam temperatures higher than 750°C are needed to compensate the efficiency loss caused by CCS and achieve a net efficiency of 45%. NEXTGENPOWER is a unique integrated project as it will demonstrate new alloys and coatings in boiler, turbine and the interconnecting pipework, which can be integrated in existing and new power plants. This proposal is aimed at the highest priority challenges for new plants and will focus on selecting and demonstrating precipitated hardened Ni alloys, and advanced protective coatings. The challenges for NEXTGENPOWER are to demonstrate that we can: • overcome the limited creep and fatigue properties of state-of-the-art materials, • overcome boiler fireside corrosion of high temperature parts, • overcome steam-side oxidation and non-allowable thermal cycling stresses of the interconnecting pipe work using Ni alloys, • manufacture steam turbine components in precipitation hardened Ni alloy steam turbine parts.

Keywords: materials,coatings,advanced power plant,boiler,turbine,corrosion,usc,biomass co-firing,ccs
Develop of a new and highly effective modeling and monitoring Energy Management System technique in order to improve Energy Efficiency and move to a low CO2 emission in the energy intensive non-metal (EE-QUARRY)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy efficiency and savings
Action type: Collaborative project
Countries involved: Spain,Italy,United Kingdom,France,United Kingdom,Poland,Spain,Spain,Greece
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 6144990.25
EU funding (EUR): 3775282.52
Participants: 12
Project status: CLOSED

The EE-QUARRY project emerges from the necessity to control a very demanding energy-intensive industry, which characterizes from its high energy demands and enormous CO2 emissions. The goal is to improve energy efficiency and to reduce CO2 on quarries, through the develop of a new and highly effective modeling and monitoring Energy Management System technique. The use of crushed stone could increase at a quicker rate than any other major material use. Given the market size, ample resources and stable growth potential of this industry, the understanding and dissemination of energy efficiency opportunities is paramount for European energy efficiency goals. Further, since there are literally several thousands facilities throughout Europe, there is a huge opportunity for replicability of identified energy efficiency measures. This project will first review the stone mining and crushing production processes. It is also important to show that energy use is focused in rock blasting, shot-rock transportation, rock crushing, conveying and screening. As such, standard building energy efficiency measures such as lighting retrofits and support system optimization have small impacts on overall plant energy use. The identification of energy opportunities thus relies heavily on systems optimization. System optimization not only encourages energy efficiency, but typically benefits production as well. Coupled with productivity improvements, the economic incentives for energy efficiency measures in this industry have the magnitude and quick payback that could facilitate industry-wide replication. Once the whole extracting industry process is over, and the quarry plant arrives to the end of its life cycle, many CO2 neutralizing activities will take place. The goal is to generate EE opportunities and CO2 compensation activities due to the environmental impact created in its life time cycle.

Keywords: quarry,innovative,solution,modeling,monitoring,energy,efficiency,low co2 emission,energy intensive industry,non-metallic mineral industry.
Transmission system operation with large penetration of Wind and other renewable Electricity sources in Networks by means of innovative Tools and Integrated Energy Solutions. (TWENTIES)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: Spain,Spain,France,Belgium,Denmark,Denmark,France,United Kingdom,Netherlands,Germany,Norway,Spain,Denmark,Portugal,Ireland,Italy,United Kingdom,Belgium,Belgium,Spain,Germany
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-04-01
End date: 2013-09-30
Duration (months): 42.0
Total project cost (EUR): 56701862.35
EU funding (EUR): 31774565.49
Participants: 29
Project status: CLOSED

A group of 6 Transmission System Operators (Belgium, Denmark, France, Germany The Netherlands and Spain) with 2 generator companies, 5 manufacturers and research organisations, propose 6 demonstration projects to remove, in 3 years, several barriers which prevent the electric system from welcoming more wind electricity, and wind electricity from contributing more to the electric system. The full scale demonstrations aim at proving the benefits of novel technologies (most of them available from manufacturers) coupled with innovative system management approaches. The contribution of wind energy to the system will show how aggregated wind farms can provide system services (voltage and frequency control) in Spain. The aggregation of wind farms with flexible generation and loads will be demonstrated in Denmark using a scalable IT platform developed by a generator. Increasing the flexibility of transmission networks will be tested in Belgium (existing sensors and coordinated power flow control devices avoiding possible large scale instabilities induced by wind farms in the CWE region) and in Spain (dynamic wind power evacuation capacity using real-time computations based on short-term generation forecasts and use of a mobile Overload Line Controller). Off-shore wind farms are addressed from a security viewpoint. Secure HVDC meshed networks will be validated in France using simulations and full scale experiments of two different HVDC circuit breaker technologies. Off-shore wind farm shut downs under stormy conditions will be demonstrated in Denmark using the world largest off-shore wind farm with balancing power provided by the Norwegian hydro capacities through a HVDC link. The experimental results will be integrated into European impact analyses to show the scalability of the solutions: routes for replication will be provided with benefits for the pan European transmission network and the European electricity market as soon as 2014, in line with the SET plan objectives.

Keywords: grid integration,renewables,set-plan
Molecular characterization of genetic factors in the pig under selection during speciation, domestication and breeding (SELSWEEP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Netherlands
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-03-01
End date: 2015-02-28
Duration (months): 60.0
Total project cost (EUR): 2496381.0
EU funding (EUR): 2496381.0
Participants: 1
Project status: CLOSED

I will analyze the changes in the genome of the pig during speciation, domestication and selection at the molecular level. Domestication and selection have resulted in a large number of distinct breeds worldwide with very distinct characteristics. Unique are also the availability of 12 closely related pig species that have diverged over a time span of 1 to 10 million years. Furthermore, the availability of a high quality genome sequence of the pig by the end of 2009 and the recent advances in next generation sequencing technology makes the SelSweep proposal extremely timely. Within the SelSweep project I will explore the genes and genomic regions that are and have been under strong selection during speciation, early domestication and during subsequent development of specific breeds in the pig. The results of the project will substantially advance our knowledge of evolutionary biology at the molecular level. Moreover, knowledge about the genes affected by selection opens up new directions for further improvement of this important livestock species. The direct sequencing of individuals from a variety of populations using next generation sequencing enables an unbiased capture of the full breadth of genetic variation in the porcine genome addressing both single nucleotide polymorphisms (SNPs) as well as copy number variants (CNVs). The analysis will be done using a previously established porcine HapMap population consisting of domestic breeds from China, Europe and the US, wild boar populations from across the world as well as museum samples representing ancient pig populations. Also included in the panel are other Suidae enabling the identification of the ancestral alleles further strengthening the identification of selective sweeps in the porcine genome.

Keywords: snp,cnv,genome,sequencing,population
Corals and global warming: The Mediterranean versus the Red Sea (CORALWARM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: Israel,Italy
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2016-05-31
Duration (months): 72.0
Total project cost (EUR): 3332032.0
EU funding (EUR): 3332032.0
Participants: 2
Project status: CLOSED

CoralWarm will generate for the first time projections of temperate and subtropical coral survival by integrating sublethal temperature increase effects on metabolic and skeletal processes in Mediterranean and Red Sea key species. CoralWarm unique approach is from the nano- to the macro-scale, correlating molecular events to environmental processes. This will show new pathways to future investigations on cellular mechanisms linking environmental factors to final phenotype, potentially improving prediction powers and paleoclimatological interpretation. Biological and chemical expertise will merge, producing new interdisciplinary approaches for ecophysiology and biomineralization. Field transplantations will be combined with controlled experiments under IPCC scenarios. Corals will be grown in aquaria, exposing the Mediterranean species native to cooler waters to higher temperatures, and the Red Sea ones to gradually increasing above ambient warming seawater. Virtually all state-of-the-art methods will be used, by uniquely combining the investigators expertise. Expected results include responses of algal symbionts photosynthesis, host, symbiont and holobiont respiration, biomineralization rates and patterns, including colony architecture, and reproduction to temperature and pH gradients and combinations. Integration of molecular aspects of potential replacement of symbiont clades, changes in skeletal crystallography, with biochemical and physiological aspects of temperature response, will lead to a novel mechanistic model predicting changes in coral ecology and survival prospect. High-temperature tolerant clades and species will be revealed, allowing future bioremediation actions and establishment of coral refuges, saving corals and coral reefs for future generations.

Keywords: corals,acidification,global warming,mediterranean,red sea,metabolism,skeletal crystallography,growth,sst,irradiance,population ecology,calcification,gene expression,reproductive biology
Building The Vertebrate Body (BODYBUILT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2015-03-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

My lab is interested in the development of the tissue that gives rise to vertebrae and skeletal muscles called the paraxial mesoderm. A striking feature of this tissue is its segmental organization and we have made major contributions to the understanding of the molecular control of the segmentation process. We identified a molecular oscillator associated to the rhythmic production of somites and proposed a model for vertebrate segmentation based on the integration of a rhythmic signaling pulse gated spatially by a system of traveling FGF and Wnt signaling gradients. We are also studying the differentiation of paraxial mesoderm precursors into the muscle, cartilage and dermis lineages. Our work identified the Wnt, FGF and Notch pathways as playing a prominent role in the patterning and differentiation of paraxial mesoderm. In this application, we largely focus on the molecular control of paraxial mesoderm development. Using microarray and high throughput sequencing-based approaches and bioinformatics, we will characterize the transcriptional network acting downstream of Wnt, FGF and Notch in the presomitic mesoderm (PSM). We will also use genetic and pharmacological approaches utilizing real-time imaging reporters to characterize the pacemaker of the segmentation clock in vivo, and also in vitro using differentiated embryonic stem cells. We further propose to characterize in detail a novel RA-dependent pathway that we identified and which controls the somite left-right symmetry. Our work is expected to have a strong impact in the field of congenital spine anomalies, currently an understudied biomedical problem, and will be of utility in elucidating the etiology and eventual prevention of these disorders. This work is also expected to further our understanding of the Notch, Wnt, FGF and RA signalling pathways which are involved in segmentation and in the establishment of the vertebrate body plan, and which play important roles in a wide array of human diseases.

Keywords: paraxial mesoderm,clock,fgf wnt notch,retinoic acid,vertebra muscle