Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Real-time Chemical Signal Processing for Microfluidic Molecular Communications: Design, Theory, Prototypes, and Applications (REACTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499977.0
EU funding (EUR): 1499977.0
Participants: 1
Project status: SIGNED

Conveying information over a distance has been a problem for decades and is urgently needed across a range of distance scales (from macro to nano) and diverse environments to ensure seamless connectivity everywhere. With the advantages of biocompatibility and energy efficiency, molecular communication (MC) has been proposed to carry information (e.g., text, image, robotic command) over a distance across macro to nanoscales via chemical signals using molecules, which is extremely important for scenarios where electromagnetic (EM) wave-based communications are unsuitable or prohibited, such as in micro- or nanoscales, tunnels, human bodies, or explosive gas environments. Until now, there exists a fundamental and long-standing challenge of the lack of microscale components that can perform real-time signal processing directly over chemical signals, which is crucial for MC transceivers and their applications. REACTION will address this fundamental challenge by drawing theory, methods, and techniques from disciplines, including communication engineering, chemistry, microfluidics, signal processing, and electronic engineering. REACTION aims to design, model, simulate, and prototype microfluidic MC transceivers and systems with complex microfluidic chemical circuits, for information exchange across different scales and environments. These circuits will be capable of performing real-time chemical signal processing across diverse concentration profiles, multiple types of concurrent molecules, and consecutive chemical pulses. The successful implementation of these designs will bring 1) a new solution for multi-robotic communication in microscale via airborne MC prototype, 2) new digital olfactory devices with the capability of gas-phase scent profile detection, transmission, and recreation for the Internet of Senses; and 3) an optimized drug injection design for efficient drug delivery.

Keywords: microfluidic molecular communications chemical signal processing
Infrastructure for Marine and Inland Water Research (AquaINFRA)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: Denmark,Finland,Norway,Estonia,Latvia,Germany,Spain,Malta,Austria,United Kingdom
Call: FAIR and open data sharing in support of healthy oceans, seas, coastal and inland waters (HORIZON-INFRA-2022-EOSC-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7601825.0
EU funding (EUR): 7601825.0
Participants: 21
Project status: SIGNED

The overall objective of the project is to develop a virtual environment equipped with FAIR multi-disciplinary data and services to support marine and freshwater scientists and stakeholders restoring healthy oceans, seas, coastal and inland waters. The AquaINFRA virtual environment will enable the target stakeholders to store, share, access, analyse and process research data and other research digital objects from their own discipline, across research infrastructures, disciplines and national borders leveraging on EOSC and the other existing operational dataspaces. Besides supporting the ongoing development of the EOSC as an overarching research infrastructure, AquaINFRA is addressing the specific need for enabling researchers from the marine and freshwater communities to work and collaborate across those two domains. A specific goal of AquaINFRA will be to develop an EOSC based research infrastructure combining the marine and freshwater domains, which will include the development of a cross domain and cross-country search and discovery mechanism as well as building services for spatio-temporal analysis and modelling through Virtual Research Environments. A set of strategic use cases including a Pan-European use case as well as more focused use cases in the Baltic Sea and the North Sea will provide the setting for co-designing and testing services in the targeted research communities. The AquaINFRA project results are expected to contribute to the utilisation of EOSC as an overarching research infrastructure enabling collaboration across the domains of marine and freshwater scientists and stakeholders working on restoring of healthy oceans, seas, coastal and inland waters.

Keywords: ocean,freshwater,biodiversity
Strategies for Wearable Energy and Thermal Management (SWEET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-02-28
Duration (months): 30.0
Total project cost (EUR): 295425.0
EU funding (EUR): 295425.0
Participants: 3
Project status: SIGNED

The UN's Sustainable Development 2030 report highlights the urgent need for net-zero emission energy to combat climate change. Renewable energy and improved energy efficiency are key, as a significant portion of energy is lost as heat. Thermoelectric generators (TEGs) offer a solution by converting waste heat into electrical power through thermal gradients. Recognising the significance of thermoelectric energy conversion materials, the Henry Royce Institute and the Institute of Physics have identified them as a critical area of materials research to achieve net-zero emissions by 2050. Current ceramic thermoelectric materials face sustainability challenges due to their reliance on scarce, toxic elements. In this context, the search for efficient ceramic materials is a necessity. Moreover, the development of hybrid materials combining ceramics with conductive polymers provides a promising alternative due to their flexibility, cost-effectiveness, and low thermal conductivity Notably, recent developments have yielded printed TEGs based on conductive polymers for energy harvesting. Nonetheless, challenges impede their optimal power output, including limited temperature differentials across the TEG. Conventional cooling solutions like pumped fluids or rigid metal fins are unsuitable for flexible TEGs, hindering their progress. This project aims to enhance flexible TEG efficiency by integrating photothermal materials, which increase the thermal gradient through sunlight-induced photothermal conversion. Comprehensive TEG modelling will guide materials optimization, fabrication, and testing. The project has broad applications, including energy-efficient wearables, remote power sources, and sustainable energy harvesting systems. Improving printed organic TEGs and addressing thermal management aim to contribute significantly to global net-zero efforts, reduce energy waste, and advance sustainable energy solutions for society and the environment.

Keywords: thermal energy harvesting,additive manufacturing,finite element modelling,nano scale chemistry,interface engineering,photothermal materials,conductive polymers,copper chalcogenides,green chem
Cytokine signaling in macrophages: beyond JAK-STAT (CYTOMAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Dysregulated macrophage function underlies many inflammatory diseases. Cytokines, small secreted signaling molecules with immune-modulatory functions, shape the macrophage’s phenotype, thereby affecting disease states. Puzzlingly, many cytokines with opposing functions, utilize highly similar JAK-STAT signaling cascades, leaving it unclear how cytokine-specific responses can occur. In my previous work, I studied enhancer activation in mouse macrophages from genetically different strains. By studying genetic variation, I found that transcription factor (TF) motifs crucial for enhancer activation can be identified. I further developed the bio-informatic tool MAGGIE to study TF motif mutations in different strains of mice, which subsequently enabled me to discover a novel TF important for enhancer activation by the cytokine interleukin-4. Based on my findings, I hypothesize that cytokines require specific, yet unidentified TFs that cooperate with JAK-STAT signaling to mount cytokine-specific effects. CYTOMAC aims to identify these cytokine-specific TFs downstream of JAK-STAT that direct appropriate cell responses. I will exploit the genetic variation across mouse strains and study enhancer activation in macrophages from these strains in response to different disease-related cytokines. Specifically, I will: (1) use genetic diversity between mouse strains to identify specific TFs regulating cytokine-specific responses; to then target these novel TFs in (2) mouse and (3) human macrophages and (4) translate my findings to human disease and inflammatory disease models. Inhibitors targeting JAK-STAT show high potential in clinically treating inflammatory diseases, including rheumatoid arthritis. However, as they affect generic pathways of many cytokines they come with considerable side-effects, limiting applicability. CYTOMAC will reveal novel, cytokine-specific TFs, which will aid in developing better tailored intervention strategies.

Keywords: macrophages,enhancers,cytokines,genetic variation,transcription factors
The i-Thymus: wielding the potential of gene therapy, cell therapy and induced pluripotent stem cells for the regeneration of the thymus and the adaptive immune system (i-THYMUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 3565015.61
EU funding (EUR): 2495510.93
Participants: 2
Project status: SIGNED

Each year, >250 babies are born without a thymus. These babies have a life expectancy of 2-3 years. The only cure is transplantation of thymus tissue, but this has a 30% mortality rate and costs almost >€2.5M. We developed i-Thymus, a revolutionary cure based on the patient’s own cells leveraging innovative gene therapy to generate thymus organoids that can be implanted minimally invasively in the patient (Fig. 1). We have already shown this works in functional proof of concept in vivo. With this EIC Accelerator, we will finalise development to enter the clinic for a Phase I/II trial, to enter the EU market with a pharma partner by 2028. After rapid market entry with ODD for complete DiGeorge syndrome, we will leverage this clinical success and our first revenues to develop i-Thymus for unmet needs of hundreds of thousands of other patients, starting with AML patients who have lost thymus function after high-dose chemotherapy for stem cell transplantation.

Keywords: advanced therapy medicinal product,cell therapy,regenerative medicine,organoid technology,induced pluripotent stem cells,thymus,gene therapy
Investigating the genome and transcriptome dynamics of early interspecific hybridization (EARLYBRID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-01
End date: 2026-02-28
Duration (months): 31.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 3
Project status: SIGNED

Hybridization has shaped the evolution of every kingdom of life. By combining highly diverged genomes, hybridization can drive genetic exchange across lineages. Hybrid genomes often present hallmarks of genome instability, but direct proof of higher rates of mutational events are lacking. What triggers genome instability in hybrids and when it arises remains a mystery. To address this question, I propose to investigate early hybrid history. I seek to conduct a comprehensive characterization of hybrid lethality, genome stability, and gene expression, employing Saccharomyces yeast as a model, due to their tractability and ability to form hybrids despite extreme sequence divergence between parental founders. These studies will focus on the early phases of interspecies hybrid clonal expansion that immediately follow zygote formation. I will first quantify how parental divergence in conjunction with environment influence the genome stability and viability of asexually expanding hybrids. Next, I will combine ultra-long read DNA-sequencing with single-cell RNA-sequencing, to assess the structure and complexity of hybrid genomes, how they evolve over time, and the genomic heterogeneity of hybrid cell populations with single-cell resolution. Finally, by conducting transcriptomic analysis of clonally expanding hybrids, I will determine gene expression dynamics at the onset of hybridization and whether the parental subgenomes converge toward similar gene expression signatures to enter the aforementioned stabilization phase. Mechanistic characterization of the interaction between hybrid viability, genome instability and gene expression phenotypes will provide an unprecedented view of how early hybrid genomes arise, are maintained and evolve.

Keywords: hybridization,hybrid incompatibility,evolution,genome instability,genome evolution,transcriptome evolution
INtegrating PLants for palaeoclimaTe. Interdisciplinary analysis on multiple plant species to reconstruct paleoclimate changes (IN-PLANTe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 2
Project status: SIGNED

Several approaches are available to reconstruct past and present climate conditions from plant material. Stable Carbon Isotope Analysis (SCIA) measures the concentration of carbon-13 (δ13C) in archaeological seeds and charcoal to determine plant water availability and allows the reconstruction of past precipitation oscillations and irrigation practices. SCIA is typically performed on the same type of plant material (wood or seeds) and species to create consistent isotope datasets. Comparing δ13C datasets from different species and plant material (wood vs. seeds) is complex due to the role played by the different species' physiology on δ13C concentrations. Nevertheless, previous studies combining δ13C datasets from multiple plant species have resulted in high-resolution paleoclimatic records. Changes in precipitation can be determined from δ13C in tree rings and by measuring tree ring features (dendromeasurements). A recent approach combines the two measurements to improve the resolution of paleoclimatic records, though their dynamics are still poorly understood. The current research aims to achieve high-resolution paleoclimate proxies from archeological plant remains retrieved in diverse South-West Asia precipitation zones, integrating classic archaeobotanical analysis, SCIA on seeds and charcoal, and tree ring analysis. In addition to providing insights into past climate changes and their effects on ancient human societies and plant-based economies, this research will significantly contribute to the methodologies employed to reconstruct paleoclimatic oscillations from plant species retrieved from archeological sequences. Similar reference measurements on modern plants will contribute to the knowledge of the dynamics between plant and precipitation oscillations. The potential of this research to advance the field of archaeobotany and paleoclimate reconstruction is substantial, making it a crucial and relevant study for the scientific community.

Keywords: upper palaeolithic,epipalaeolithic,southwest asia,archaeobotany,stable carbon isotope analysis,dendroclimatology
CHampioning a European Advanced Manufacturing Pilot Line of ION-traps (CHAMP-ION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Framework Partnership Agreement
Partnership: CHIPS (JU-JTI)
Countries involved: Austria,Germany,Portugal,Finland,Italy,Czechia
Call: Quantum Chip Technology for high-quality Trapped Ions Pilot (HORIZON-JU-Chips-FPA-QAC-2, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 21
Project status: SIGNED

CHAMP-ION aims to leverage EU fabrication capabilities to ensure sovereignty and lead in ion-trap quantum technologies by establishing an inclusive and sustainable, high quality pilot line network across the EU to advance ion-trap chip (ITC) innovation, securing the EU supply chain, supporting SME and Start-Up involvement, and establishing standards for industrialization and mass production. CHAMP-ION focuses on enabling Europe’s first open access pilot production capabilities for ITCs to advance EU’s competitive advantage in this key enabling technology by expanding high-quality industrial production with improved reliability. CHAMP-ION’s technical vision is to provide the entire value chain, from design to microfabrication and testing, for validated fully integrated and mass-producible advanced scalable ITCs exploiting integrated electronic and photonic structures on a chip. CHAMP-ION intends to drive ITC technology transfer from experimental to high yield, high quality production with advanced features for the next 10+ years by: (1) coordinating internal management of the Pilot Line (2) establishing and operating high quality fabrication capabilities for ITCs, including first-mover development of ITC Process Design Kits (PDKs) (3) ensuring mature advanced feature integration enabling scalable and efficient solutions for quantum technologies and (4) fostering inclusive network outreach, including a professionally managed single entry point, to enhance the market of interested target groups who can foster European utilization of ITCs. CHAMP-ION will become a central pivot point and incubator for the EU ion-trap industry, providing a one-stop-shop to high-quality ITCs tailored to user needs, and open to all EU stakeholders. This will empower an efficient, sustainable, competitive and resilient ecosystem of ITC-based quantum technologies that will improve EU strategic autonomy with applications in QU-communication, QU-sensing, QU-simulation and QU-computing.

Keywords: high quality fabrication,ion trap chips,pdks,quantum pilot line,european strategic autonomy,quantum advantage,scalable production,qu communication,qu computing,qu sensing,qu simulation
Green deal inspired correlative imaging-based characterization for safety profiling of 2D materials (ACCORDs)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Slovenia,Germany,United Kingdom,Italy,South Africa,Netherlands,Spain,Switzerland
Call: Advanced characterisation methodologies to assess and predict the health and environmental risks of nanomaterials (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 1674150.0
EU funding (EUR): 1669149.75
Participants: 10
Project status: SIGNED

ACCORDs will develop an imaging-based characterization framework (ACCORDs framework) for the holistic correlative assessment of Graphene Family Materials (GFMs) as a representative of 2D nanomaterials (NMs) to assess and predict 2D NMs health and environmental risks. The ACCORDs framework will operationalise safe and sustainable by design (SSbD) strategies proposed in past or ongoing H2020 projects or within OECD by correlating low-, medium-, and high-resolution physico-chemical-biological imaging-based methods with non-imaging methods in a tiered approach. ACCORDs will deliver the ACCORDs framework and user guidance, new imaging-based characterisation methods (3-6 methods), reference in vitro tests (up to three new tests), new reference 2D NMs (up to three) for different matrices, a new minimum information reporting guideline for FAIR data sharing and reuse of images as well as an atlas with reference images for diagnostics of compromised safety of GFMs / GFM products. The new guidelines and standard proposals will be submitted to standardisation bodies to allow creation of regulatory ready products. The novelty of ACCORDs is in translating the principles of medical imaging-based diagnostics to 2D material hazard diagnostics. ACCORDs will accelerate industrial sectors in the area of aviation, marine construction, drone production, flexible electronics, photovoltaics, photocatalytics and print inks-based sensors. The value ACCORDs proposes to the graphene industry are practical, easy, imaging-based tools for GFM quality monitoring next to the production line with a possibility to be correlated with advanced high-resolution imaging characterization methods in case hazard i.e. deviation from controls (benchmark values) are diagnosed. The ACCORDs framework and tools will contribute to the European Green Deal by addressing the topic: “Graphene: Europe in the lead” and to a new European strategy on standardization, released on 2nd February, 2022.

Keywords: graphene enabled products,imaging based characterization,2d material saftey profiling,standardisation,refercne material