Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synthetic Lethal Phenotype Identification through Cancer Evolution Analysis (SPICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 1996428.0
EU funding (EUR): 1996428.0
Participants: 1
Project status: CLOSED

Prostate cancer (PCA) is a genetically heterogeneous disease. Advances in targeted hormonal therapy (second generation anti-androgens) have led to more effective management of castration-resistant prostate cancer (CRPC). Despite these highly potent drugs, disease recurs with new genomic and epigenetic alterations. In this ERC proposal, I will leverage my expertise in cancer genomics and a new computational methodology to unravel the landscape of lethal PCA, with a focus on determining the Achilles’ heel of these aggressive tumours. In Aim 1, I will take advantage of DNA sequencing data from over 1000 patient-derived tumour samples and use highly innovative mathematical algorithms to create a detailed evolution chart for each tumour and identify driver events leading to CRPC. After nominating candidate drivers, we propose testing 10 using in vitro gain- and loss-of-function validations experiments (i.e., CRISPR/Cas9, shRNA, and Tet-On assays) in PCA cell lines using migration, invasion, and cell cycle as readouts. In Aim 2, I will focus on genomic events that occur in recalcitrant CRPC, positing that genetic alterations occurring prior or secondary to treatment harbour clues into resistance. In vitro validations will be performed on the top 10 biomarkers. In Aim 3, I will nominate synthetic lethality combinations by mining CRPC genomic data taken from Stand Up 2 Cancer CRPC clinical trials. I will prioritize mutually exclusive genomic alterations in genes for which approved drugs exist. The top 5-10 candidates will be validated in a prostate lineage-specific manner. In summary, this ERC proposal will leverage my many years of expertise in PCA genomics and emerging public and private CRPC datasets to uncover driver mutations that will enhance our understanding of recalcitrant CRPC. Successful completion of this study should lead to novel treatment approaches for CRPC and to a computational model that may transform our approach to evaluating other cancers.

Keywords: castration resistant prostate cancer,tumor heterogeneity
Integration of processes and moDules for the 2 nm node meeting Power Performance Area and Cost requirements (ID2PPAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Austria,Germany,Germany,Israel,Germany,Germany,Spain,Germany,Belgium,France,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands
Call: ECSEL-IA (H2020-ECSEL-2020-1-IA-two-stage, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 107273167.38
EU funding (EUR): 24842000.23
Participants: 27
Project status: SIGNED

In the ID2PPAC project the technology solutions for the 2nm node identified in the preceding project IT2 will be consolidated and integrated with the objective to demonstrate that Performance Power Area and Cost (PPAC) requirements for this generation of leading edge logic technology can be achieved. To continue the Moore’s law trajectory to the 2nm node, while meeting PPAC requirements, the combination of further advancements in EUV lithography & masks, 3D device structures, materials and metrology is required. The strength of the project pivots on the focused engagement of leading expert partners in these key interlocking areas and a shared pilot line. The ID2PPAC project, is expected to enable IC-fabs to do EUV-based, single-print, High Volume Manufacturing for the 2nm node by 2025. This technology evolution is driven by the growing demand for compute power which increases more than exponentially with time and has made the world migrate from 1 billion interconnected devices in the “PC era” to 10 billion in the “Mobile + cloud era” to the future “Intelligence era” in which there will be over 100 billion intelligent connected devices. To enable this growth, the semiconductor industry is continuously pursuing technology innovations to realize this progress as has been predicted by Moore’s Law and will continue to do so. The project will also help to expand Europe's technological capacity to act in this field, which is crucial for digitization, (edge) AI and for solving national, European and global societal challenges and will strengthen the consortium of leading European companies and institutes active in this sector.

Keywords: semiconductor,process,lithography,metrology,mask,equipment,nano,technology,materials,moore s,heterogeneous,system engineering,dtco,stco,edge computing
Spinal Exoskeletal Robot for Low Back Pain Prevention and Vocational Reintegration (SPEXOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Austria,Germany,Belgium,Slovenia,Netherlands,Netherlands
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3989025.0
EU funding (EUR): 3989025.0
Participants: 8
Project status: CLOSED

Low-back pain is the leading cause of worker absenteeism after the common cold, accounting for 15% of sick leaves and hundreds of millions of lost work days annually [Walking 2.0, Nature, 2015]. Most of today's robotic assistive devices are in forms of exoskeletons that augment the motion of legs and arms and neglect the role of spinal column in transferring load from the upper body and arms to the legs. In SPEXOR we will fill this gap and design a novel and revolutionary spinal exoskeleton to prevent low-back pain in able bodied workers and to support workers with low-back pain in vocational rehabilitation. The concept to realize the objectives of SPEXOR is driven by several interdisciplinary ideas that push current understanding of low-back pain intervention through several innovative research and technological stages. First, robot-centred requirements for low-back pain prevention are determined and a musculoskeletal stress monitoring system is developed to unobtrusively measure the associated key variables. Then, optimal design parameters and sensorimotor strategies are provided with respect to the robot-centred requirements and their associated key variables. Based on these aspects, a spinal exoskeleton mechanism and its actuation is developed and adaptive control architecture is employed. Such research and development cycle is enclosed by multi-phase end-user evaluation, usability and satisfaction studies. The project builds upon the partner's extensive experience with work ergonomics, modelling and optimization of human movement, design, control and evaluation of exoskeletons. Several beyond-the-state-of-art scientific approaches and technologies will be employed through a colourful mixture of research, industrial, SME and end-user partners of the consortium. Ultimately, the results of SPEXOR will have a significant impact well beyond the current scientific understanding and technological capabilities of assistive robots used in daily life and health care.

Keywords: spinal exoskeleton,active orthosis,compliant actuators,low back pain,musculoskeletal stress
Studying the Effect of Geometrical Features on Megathrust Earthquakes using Natural Observations and Seismotectonic Numerical Models (SEGMENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: TERMINATED

Earthquakes and associated tsunamis cause extensive human and economic losses and severe property damage in densely populated areas. The largest earthquakes occur in subduction zones, regions where one tectonic plate dives below another. To better prepare society, it is crucial to understand what controls the spatial and temporal occurrence of those largest earthquakes. Geometrical features on the seafloor that subduct with the downgoing plate, like seamounts and ridges, are thought to play an important role by segmenting the plate interface into seismic and aseismic regions. However, a physical and quantitative understanding of the role of geometrical features on the occurrence of earthquakes remains elusive due to limitations in observation time and space, as well as in modelling of crustal deformation mechanisms in 2D and 3D. SEGMENT will overcome these limitations through integrating the latest advanced forward and inverse modelling tools to study how and how much subducting geometrical features influence subduction earthquakes. Seismotectonic numerical models will be combined with probabilistic natural observations from geodesy and seafloor roughness to optimally extract complementary information and quantify elusive links. As these necessary tools are only now ready for exploration this proposal is highly timely. It will address important open questions related to how geometrical features influence the deformation at and around the plate interface, how this varies throughout multiple earthquake cycles and their role in rupture nucleation, propagation and arrest. SEGMENT thus places me in the position to make a breakthrough in a long-standing debate through providing a novel conceptual model describing the relationship between geometrical features along the subduction interface and the occurrence of earthquakes. This is crucial for improving seismic hazard assessment and our comprehension of subduction dynamics at all timescales.

Keywords: subduction zones,earthquakes,seismotectonics,seafloor features,numerical modelling,geodesy
Literary Communities and Literary Worlds (LCLW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

What part does context play in the making of literary works and their meanings? What, precisely, do literary scholars mean when they speak of context? These two fundamental questions are at the heart of Literary Communities and Literary Worlds (LCLW), which seeks to answer these questions by addressing the careers of several literary exiles of the mid-twentieth century: Vladimir Nabokov, Stefan Heym, Richard Wright, and Peter Abrahams. Each of these authors was forced to move abroad mid-career, at a time of global conflict and intense migration not dissimilar to our own. Moreover, each sought to gain entry to a new literary culture. It is by studying their strategies of entry and integration that we are able to reveal the special importance of literary context, and, indeed, literary community in the shaping of works; and it is by focusing on border-crossing and belonging that we are able to advance current conceptions of the literary world, and, indeed, world literature, and thereby respond to the trans-national turn across the humanities, which has tended to stress dislocation and displacement over location and embeddedness. LCLW will ask: How are literary communities constituted? What are the conditions of entry, departure and belonging? And how important is literary practice, rather than physical presence, in determining membership? Its method is innovative in combining formal analysis with book history and the sociology of literature. It builds on the ER’s previous research experience, especially his work on the ‘literary field’, and will be greatly augmented through the supervision of Professor Nicholas Brown at the University of Illinois-Chicago, a leading expert in theorising the field; and of Dr Danielle Fuller at the University of Birmingham, , whose own work has advanced understandings of twentieth-century book history and communities of readership. A secondment at the George Padmore Institute will give the project an inter-sectoral dimension.

Keywords: literary community,literary field,world literature,cold war,exile,vladimir nabokov,stefan heym,richard wright,peter abrahams,pierre bourdieu,context of intelligibility
HLG - chair support (HLG - chair support)

Framework: Horizon 2020 — Societal Challenges
Action type: Coordination and support actions
Countries involved: France
Call: Grant to identified beneficiary to support the Chair of the High Level Expert Group on the interim evaluation of Horizon 2020 * (H2020-IBA-19-CHAIR-2017, 2017)
Start date: 2017-03-15
End date: 2017-07-14
Duration (months): 4.0
Total project cost (EUR): 40000.0
EU funding (EUR): 40000.0
Participants: 1
Project status: CLOSED

Support to the Chair of the High Level Group High Level Expert Group on maximising the impact of EU Research and Innovation programmes as part of the interim evaluation of Horizon 2020.

Keywords: analytical,administrative support
High tech Inliner for ISO tank containers (Mega-Inliner)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global tank container fleet has grown almost 50% from 2013, reaching 508,000 units by the end of 2016 since bulk shipping made possible is much more efficient compared to traditional transport methods. Thus, ISO tank containers have developed for intermodal carriage of bulk liquids ranging from non-hazardous to hazardous liquids, eliminating the risk of spillages through transferring liquids from one vessel to another providing an extremely safe, secure, and versatile mode of transportation. Nevertheless, nowadays the intensive use of ISO tank containers is constrained by the need of cleaning after each use to be ready for its next load. This task coupled with the insufficient number of cleaning stations entails higher direct costs (€250-1200/cleaning) but also indirect ones since the containers are stocked several days limiting their availability. These lead towards logistic inefficiencies, such as empty return journeys due to prior cargo constraints. Moreover, the lifetime of ISO tank containers, is highly dependent on the cargo being shipped and frequency of cleaning. On the other hand, flexitanks-an alternative solution-poses serious concerns regarding the possibility of spillages, unused space and their installation is expensive. Mega-Inliner® aims to revolutionize the bulk liquid transportation industry by introducing the first one-use high-tech Inliner for ISO tank containers designed for intermodal transport. Removing the need for cleaning the tank after discharge, it eliminates all the concerns associated with the use of ISO tank containers. Thus, a huge optimization of logistics is realized allowing for transport costs reductions of 20-75% depending on type of current packaging used, liquid cargo and volume transported. Having set brewery sector as our initial target market, we are currently running operational test of our prototype with water and beer cargos in ISO tank containers which has demonstrated our technology in a relevant environment.

Keywords: inliner,iso tank,liquid bulk,logistics
An innovative tool for non-invasive evaluation of myocardial stiffness (ElastoCardioScope)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

Heart failure (HF) affects 14 million people in Europe, and this number is expected to increase to 30 million by 2020. Early diagnosis of HF is essential for successfully addressing underlying causes. However, initial diagnosis is difficult in many situations so that HF is correctly diagnosed in only half of patients. Diastolic HF, that accounts for more than 50% of all HF patients, is due to abnormal ventricular stiffness which remains very difficult to diagnose. The characterization of myocardial properties remains today a challenge and there is no technique that can assess myocardial stiffness in clinical practice. Shear Wave Imaging (SWI), a novel ultrasound technique, has been shown capable of quantifying myocardial stiffness. The development of SWI for transthoracic evaluation of myocardial stiffness in patients is one of the major goal of ULTRAECHOCARDIO, the related ERC-funded project. To achieve this goal, ultrafast ultrasound imaging is developed in order to provide thousands of images per second of the heart requiring the development of complex equipment and imaging methodology. In ElastoCardioScope, a novel portable ultrasound device will be developed for non-invasive quantification of myocardial stiffness. The idea of ElastoCardioScope is to develop a simple and innovative approach for SWI that 1) quantifies myocardial stiffness transthoracically, 2) evaluates myocardial function through time-varying stiffness and 3) is cost effective. In contrast with SWI that requires costly and complex multichannel electronics and transducers, this project aims to develop a low cost and portable approach which does not rely on ultrafast imaging of the heart. The clinical proof of concept of this technology will be performed on patients with diastolic HF. This simple and low cost innovative technology will provide a clear solution to unmet medical needs and thus has great potential for take-up and use by clinicians at hospital but also in other points of cares.

Keywords: heart failure,myocardial stiffness,ultrasound
Micro-botanical Analyses at Cenozoic fossil localities from East Africa: new insights into the evolution of savannas in Africa from 50 million years (MACEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 246668.4
EU funding (EUR): 246668.4
Participants: 2
Project status: CLOSED

Today, the savanna biome occupies ~50% of Africa’s land surface, and is associated with many mammal species specifically adapted to life in the savanna environment. The present project, MACEA, aims to document the appearance and expansion of savannas in Africa’s geologic past, and to evaluate their relationship with the evolution of modern mammals. Precisely, MACEA will assess savanna history in Africa via phytoliths, microscopic particles of amorphous hydrated silica produced in plant tissues and conserved in sediments post-mortem. A unique aspect of this study is that it will apply phytolith analyses for the first time to document paleoenvironments older than ~15 Ma in Africa, and to bring the great potential of phytoliths to bear on the question of savanna origins in Africa. The MACEA project consists of two phases: an outgoing phase at the University of Washington (Seattle, USA), and a return phase at CEREGE (Aix en Provence, France). Both labs will provide all needed equipment, training, and expertise. Upon its completion, MACEA will have created new modem and fossil phytolith datasets, new modern phytolith calibrations, as well as new paleovegetation reconstructions at the scale of tropical Africa. Publications resulting from this study will be of interest to paleobotanists, paleomammalogists, paleoclimatologists, and those concerned with conservation of modem biodiversity in Africa.

Keywords: africa,savanna,grass,mammals,biodiversity,evolution,phytoliths,paleovegetation,paleoclimate
Cultures of Disaster Resilience among children and young people (CUIDAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Italy,Spain,Greece,United Kingdom,Portugal,United Kingdom
Call: Ethical/Societal Dimension topic 2: Better understanding the links between culture, risk perception and disaster management (H2020-DRS-2014, 2014)
Start date: 2015-07-01
End date: 2018-06-30
Duration (months): 36.0
Total project cost (EUR): 2009653.5
EU funding (EUR): 2009653.5
Participants: 6
Project status: CLOSED

Cultural sensitivity is essential to effective disaster management and disaster risk reduction, yet disaster plans still largely ignore the needs and capacities of children and young people. Addressing Topic 2 of this call, the ‘given cultural group’ is therefore children, not viewed as a homogenous group, but one which offers diverse cultural perspectives and diverse experiences of roles taken on in disasters. By ‘culture’ we mean more than ethnicity, important though that is; we also refer to social class, vulnerability, age, gender, disability and migration status. Cultures of Recovery and Resilience among children and young people in Disasters (CUiDAR) will address the exclusion of children and young people from the disaster planning and management process; it will provide innovative and creative communication channels for children’s voices to be heard and it will develop a child centred disasters management framework for use by policy/decision makers in participating countries, the EU and beyond. To achieve the objectives we have designed a suite of activities: scoping; dialogues with children (consultative workshops); regional level mutual learning exercises; national level awareness and communication events; framework design/building, and an in-depth ongoing approach to dissemination. Our unique partnership with the major children’s charity Save the Children enables the Consortium to work closely with children to achieve our objectives. Our strong existing links with emergency planners and authorities enables us to access key audiences. Each workpackage is designed to create stronger awareness of needs and capacities of children and will enable enhanced local, national and EU institutional and policy response for what is a growing and urgent societal problem: how to develop meaningful and effective disaster management (including response, recovery and resilience).

Keywords: children,disasters,resilience,preparedness,cultural sensitivity,emergency management,urban vulnerability,risk perception