Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolism of Novel Strains of Arctic Algae (MONSTAA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-04-30
Duration (months): 32.0
Total project cost (EUR): 231642.2
EU funding (EUR): 231642.2
Participants: 2
Project status: CLOSED

Due to increasing environmental and economic pressures, there is a need to develop more efficient and sustainable food, feed and fuel production systems. Microalgae have substantial potential as single-cell molecular factories for producing high quality lipids, proteins and carbohydrates. They are capable of faster growth rates than crop plants and synthesize valuable metabolites that do not occur naturally in other primary producers. However, a major bottleneck that currently limits widespread microalgae production are the low yields achieved by commercial strains in cold climates. This project will develop new varieties of microalgae isolated from Arctic and Antarctic environments for applied bioprocesses. The work will include studying the metabolism of novel microalgae in low temperature bioreactors using functional genomics. The researcher will spend the outgoing phase at an established microalgae metabolism laboratory in the USA, where complete and very high quality training will be given in cutting-edge Next Generation Sequencing (NGS) technology. Genomic and transcriptomic work will be paired with metabolomics to give new insights into the regulation of metabolism in non-model microalgae species. The research will also include integrating data together into metabolic flux model frameworks. The major research outcomes will be (1) Genome-scale characterization of brand-new varieties of microalgae (2) Development of novel microalgae bioprocesses for high yields of lipids, proteins and carbohydrates in cold climates (3) Predictive metabolic models for maximizing yields of products of interest in non-model varieties of microalgae. In addition, comprehensive work and dissemination plans are presented that will target scientists, industry and the public.

Keywords: microalgae photobioreactor,food,feed,functional genomics,transcriptomics,metabolomics,metabolic networks,biofuel,arctic bioscience,aquaculture
What does it take to build an artificial virus? (GENESHUTTLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 2495310.0
EU funding (EUR): 2495310.0
Participants: 1
Project status: SIGNED

Using rational design with DNA origami, we propose to create synthetic virus-like assemblies capable of accomplishing cell-invading and gene expression functionalities known so far only from natural viruses. We envision these assemblies to be useful for studying and testing viral import mechanisms, and also for gene delivery, enabling fundamental studies and potential medical applications. The objectives include selecting and invading a target cell type, systematically solving the challenges of endosomal escape and nuclear delivery, and inducing the expression of user-defined genetic information in the nucleus. To achieve these objectives, we will recreate and experimentally test mechanisms believed to be used by viruses, including receptor-mediated endocytosis, stimulus-dependent lipid membrane penetration, membrane fusion, active cytosolic transport, and nuclear import. We foresee building synthetic shells carrying genetic information stored in nucleic acids, which we refer to as the “gene shuttle”. The particles will optionally include a membrane envelope and user-defined surface features to mediate receptor-ligand interactions with cell membranes, and they will be capable of stimulus-dependent conformational changes to trigger membrane fusion or membrane penetration. They will shed structural elements on the path to the nucleus, similar to viruses. In addition to delivering genes for fluorescent markers, as a proof of concept demonstration we plan to use the gene shuttle to deliver the genetic information for expressing chimeric antigen receptors (CAR) in a T cell line, which promises to be of use in cancer immunotherapy. The project promises to yield a gene delivery system with capabilities beyond current synthetic vectors, which struggle to overcome the many cellular barriers to deliver and express genetic cargo. For safety reasons, the gene shuttle will by design be unable to assemble in the context of a cell to prevent uncontrolled autonomous replication.

Keywords: self assembly,dna origami,dna nanotechnology,gene delivery,endocytosis,endosomal escape,nuclear import,biophysics,bottom up,synthetic biology
Highly Conductive Graphene Ink (HiGRAPHINK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 149949.0
EU funding (EUR): 149949.0
Participants: 1
Project status: CLOSED

Graphene's unique electrical and optical properties make it ideal for a variety of applications, in particular for flexible (opto)electronic devices, such as mobile phones, tablets etc. Current flexible electronic devices are based on organic semiconducting materials with excellent current switching but poor charge carrier mobility, which result in a slow response. HiGRAPHINK aims to unlock this limitation by demonstrating the viability of graphene as additive to printed organic semiconducting materials, aiming to improve their mobility. The devices will be made into flexible active matrix arrays to drive proof of concept Organic Light Emitting Diode (OLED) displays. Combining graphene and organic semiconducting materials may significantly improve the performance of flexible active matrix arrays, enabling a range of foldable and portable consumer electronic devices

Keywords: graphene,printed electronics,flexible electronics
Flexible smart metering for multiple energy vectors with active prosumers (FLEXMETER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Italy,Italy,Italy,Romania,Sweden,Belgium,France
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3869607.25
EU funding (EUR): 3197791.38
Participants: 15
Project status: CLOSED

The introduction of the electricity market, the widespread diffusion of distributed generation from renewable and non-programmable energy sources and the need for storage are quickly changing the problems that Transmission and Distribution system operators have to face in their activity and are requiring a “smarter” grid. A first step in this direction is the development and installation of a flexible smart metering architecture for multiple energy vectors. Up to now the smart meters that in some countries are being installed at the users are nearly only devoted to billing improvements. The new metering systems must go much further to provide their contribution to various objectives such as end-user affordability of electricity, energy and market efficiency improvement, CO2 emissions and pollutants reduction. In the FLEXMETER project a flexible, multi-utility, multi-service metering architecture will be designed and deployed in two demonstrators. Simple off-the-shelf meters will be placed at the users for electric, thermal and gas metering; they will communicate with a building concentrator, where the “smartness” of the metering system will reside. A central cloud system will collect data from the building concentrators and from MV/LV substation meters. Data collection, fusion and mining algorithms will be adopted. The proposed architecture will allow for innovative services for the prosumers (e.g. analysis of the energy consumption), for the Distribution System Operators (DSOs) (e.g. fault detection, network balancing and storage integration) and for the retail market. Also demand side management devices could be plugged into the system. In the FLEXMETER project two pilot applications in two different countries (Italy and Sweden), on real systems, with the involvement of the local DSOs and volunteer prosumers will be demonstrated. The results on the demonstrators will then be scaled up to the size of the cities in order to evaluate the advantages on a real scale.

Keywords: smart metering,multiservice,interoperability,energy data communication,load profiling
Software Testing AMPlification (STAMP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Türkiye,Norway,Norway,Romania,Sweden,France,France,France,France,France,Netherlands
Call: Software Technologies (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 4307070.0
EU funding (EUR): 4307070.0
Participants: 16
Project status: CLOSED

Release early, release often. Such is the mantra of IT giants like Twitter or Netflix. Pioneers in the engineering of applications that run in the cloud now routinely perform hundreds of code updates per day in what has become a thrust of continuous delivery around the clock. This stunning agility is a decisive competitive edge. It cuts time-to-market and hikes revenue. Behind the feat lies DevOps. This powerful development methodology brings high degrees of automation at all steps of construction and deployment. DevOps has gained more traction in the USA than in Europe and concern is raised that European companies may be “missing the train”. Their disinclination is thought to reflect a different cultural attitude toward risk. Indeed, a hasty deployment may propagate a regression bug into production due to lack of sufficient testing. Fear of breaking things is all the more justified as testing in DevOps mostly relies on manual effort. Leveraging advanced research in automatic test generation, STAMP aims at pushing automation in DevOps one step further through innovative methods of test amplification. It will reuse existing assets (test cases, API descriptions, dependency models), in order to generate more test cases and test configurations each time the application is updated. Acting at all steps of development cycle, it will bring amplification services at unit level, configuration level and production stage. STAMP will raise confidence and foster adoption of DevOps by the European IT industry. The project gathers 3 academic partners with strong software testing expertise, 5 software companies (in: e-Health, Content Management, Smart Cities and Public Administration), and an open source consortium. This industry-near research addresses concrete, business-oriented objectives. All solutions are open source and developed as microservices to facilitate exploitation, with a target at TRL 6.

Keywords: software testing,program analysis,microservice architecture,open source development
Development of the flow through bioreactor of 3D-structured bacteria for biodegradation of aromatic chloroderivatives from contaminated water (cryo-bacteria-reactor)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-15
End date: 2018-09-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Polychlorinated biphenyls PCBs, are a group of chemicals now considered among the most hazardous pollutants in the world. The presence of these extremely stable compounds in trace concentrations in water have been linked to an increased risk in frequency of cancer. PCBs were used for production of various industrial capacitors, pesticides and herbicides over a number of years; and still appear in ground and water. Existing multistep water purification processes for PCBs and other chlorinated contaminants are expensive mostly due to usage of different chemicals. Bioremediation processes utilising bacteria represents an alternative to existing chemical methods. Immobilisation of bacteria on a substrate reveals many benefit over free bacteria systems, such as higher biomass content, high metabolic activity, resistance to toxic chemicals, allowing continuous process operating and avoiding the biomass- liquid separation requirements. The immobilised bacteria can be reused several times opening opportunities for developing cost-effective processes for wastewater treatment. In this project Dr. Berillo will apply a cutting-edge technology, he developed the direct cross-linking of the bacteria cells into a 3D-structured macroporous, highly permeable system that will be used for selective and efficient purification of contaminated water from aromatic chloro derivatives (chlorophenols etc.). Advantages of the novel system are: one step immobilisation, high density of immobilised cells; no diffusion restriction of contaminant to the cells and possibility to exploit the system as a flow through bioreactor. This is an inter- and intra-disciplinary proposal involving the combination of knowledge and expertise in microbiology, cryotechnology, organic, polymer, physical, analytical, environmental and surface chemistry. The project intends to solve sophisticated problems of Environmental remediation through combination of microbiology and polymer chemistry.

Keywords: cryogel,chlorophenols,biodegradation,water treatment,cross linking of bacteria
Next-Generation Energy-Management Upgrading Energy Management Systems with a Next-generation, smarter, resource-saving software with unique automatic pattern recognition of energy consumption data (Next-EMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Company IngSoft GmbH has developed an innovative Energy Management System (EMS) with the up to this day unique feature of automatic recognition of energy consumption patterns. The technology named IngSoft InterWatt has a broad application potential at large organisations and companies in sectors where energy management requires the monitoring of a large variety of energy consumers (e.g. energy-intensive factories, municipalities, public utilities, food/ supermarket chains). The algorithms developed by IngSoft provide transparency over several 10.000 energy consumption data and automatically detect and classify captured data anomalies. Conventional EMS methods are not able to detect certain classes of errors and require considerable effort for energy managers, who must find, define and maintain threshold values in energy consumption. IngSoft InterWatt allows users to quickly resolve defects leading to unnecessary energy consumption with the impact of realising up to 10% more latent energy savings with 50% lower staff effort than with conventional EMS. IngSoft addresses the market of EMS with a global volume of $31.3 billion and growing demand since the introduction of ISO 50001 standard for EMS in 2011. However, only about 50% of these certifications have been obtained outside Germany. This represents a considerable latent market potential for IngSoft InterWatt – and at the same time energy and CO2 saving – in other European countries. Aim of this phase 1 project is to identify the potential of the innovative solution in predefined European markets and the elaboration of a business plan for its successful market introduction. The demand for the software is guaranteed by the strong interest of beta-test customers and of interested customers (currently in DACH countries). According to preliminary calculations, IngSoft expects to reach, just with the Next-EMS innovation project, a turnover of €9.22 million in 2024 and a staff growth of additional 42 employees.

Keywords: energy management system,software,energy efficiency,energy intensive industry,public utilities,municipalities,food,supermarket sector,iso 50001,energy consumption pattern recognition
Exploring the dynamics and causes of prehistoric land use change in the cradle of European farming (EXPLO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Switzerland,Greece,United Kingdom
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 6403199.0
EU funding (EUR): 6403199.0
Participants: 3
Project status: SIGNED

European societies today face unprecedented environmental change. Understanding how human societies responded to past challenges of environmental change relates to the interface between culture and environment. The EXPLO project proposes a novel interdisciplinary approach to investigate key questions regarding the interaction between past human ways of life, land use and the wider environment through a unique combination of archaeological, biological and dynamic mathematical modelling approaches. Archaeological prehistoric sites in lakes of northern Greece and the southern Balkans provide an excellent opportunity to investigate rich archives of societal and environmental change in the cradle of European farming. Natural lake sediments and submerged prehistoric settlements offer exceptional preservation conditions and uniquely holistic insights into past anthroposphere, biosphere and geosphere dynamics. More than 8,000 years ago, technological and social breakthroughs allowed the introduction of farming from western Asia to Greece and thus for the first time to Europe; however, so far there is no high-resolution picture of how this revolutionary innovation interacted with the environment, including its long-term consequences. New underwater archaeological research will allow the construction of highly precise settlement chronologies on the basis of dendrochronology, radiocarbon dating and Bayesian modelling. On-site information from excavations will be combined with off-site palaeoenvironmental data from the same lakes to investigate past adaptation strategies to the environment as well as the effects of past societies on their environments. Dynamic models integrating archaeological contexts and palaeoenvironmental data will open up the opportunity to investigate vulnerability, resilience, tipping points and thresholds of ancient agrarian economies, with implications for future food systems under a rapidly changing climate.

Keywords: neolithic,bronze age,paleoecology,bioarchaeology,balkans,northern greece,wetlands,underwater archaeology,early agropastoral societies,lande use,anthropogenic land cover land use change
New technology for improved food security and food safety to meet the increasing demand from consumers (TriQ)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will develop a business plan for the international expansion of BoMill’s TriQ technology – a revolutionary single kernel grain sorting technology based on near-infrared (NIR) analysis in transmittance mode. In the modern agriculture economy, the availability and quality of grain, and the knowledge of their different quality fractions are recognized as determinants of the sustained food security and food safety. Any changes in the numbers, size, or quality of grains are important because they influence the yield. Grain sorting equipment is used to remove the offending material (e.g. fusarium infested kernels) from the batch to boost the economic value of the remaining grain fraction. However, the grain industry is still lacking an efficient method of achieving this goal. Today, the main technology used is optical sorter (sorting by visible surface properties). The low accuracy of this method results in unmotivated downgrading of a large part of the grain produced, lower yield from the harvested area and lost revenue for the producer. The TriQ system is the first technology enabling sorting beyond visible surface properties. With TriQ, every single kernel of an entire batch is analysed and sorted according to its internal quality. This means that high quality fractions can be segregated out of batches that have an inferior average quality, allowing the user to maximize yields and capture the hidden value. TriQ fulfils thus a clear unmet market need and has the potential to revolutionize the grain sorting industry. With its unique sorting capabilities, the TriQ system contributes to food security and food safety in different places in the value chain from “farm to fork”. BoMill’s strategy is to establish the company on an international level as the “first of choice” provider of grain sorting technologies. The project is the key step towards realising this vision.

Keywords: grain sorting technology,fusarium infestation,precision agriculture,yield maximisation,single,kernel sorting using near infrared nir light in transmittance mode