Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Low-dimensional topology in Oxford (OXTOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1497422.0
EU funding (EUR): 1497422.0
Participants: 1
Project status: CLOSED

This project aims to build a group that brings together experts in gauge-theoretic, geometric, and group-theoretic techniques. It consists of 4 branches. 1. Cobordism maps in knot Floer homology (HFK). Defined by the PI, these should yield invariants of surfaces in 4-manifolds. Hence, they could be used to bound the 4-ball genus and the unknotting number, providing a tool for finding a counterexample to the smooth 4-dimensional Poincaré conjecture, and to decide whether a given slice knot bounds a ribbon surface. The cobordism maps seem to yield a spectral sequence from Khovanov homology to HFK. An important biological application is an obstruction for two links to be related by a band surgery. 2. TQFTs. We use our classification of (2+1)-dimensional TQFTs in terms of GNF*-algebras and MCG representations to find new examples of such TQFTs. First, we simplify the algebraic structure, then determine when a GNF*-algebra corresponds to a (1+1+1)-dimensional TQFT. This would allow us to find a (2+1)-dimensional TQFT that is not (1+1+1)-dimensional. 3. Heegaard Floer (HF) homology and geometrization. There are currently few links known between Floer-theoretic invariants of 3-manifolds and the geometric structures they admit. We propose to study the Floer homology of arithmetic 3-manifolds. These are often L-spaces; the question is when this happens, and whether the HF correction terms contain any number-theoretic information. The next step is studying the relationship between HF and the Thurston geometries, and then gluing along tori via bordered Floer homology. An important step is to understand the behaviour of HF under covering maps. 4. The Fox conjecture. This states that the absolute values of the coefficients of the Alexander polynomial of an alternating knot form a unimodal sequence. We propose a strategy for attacking this conjecture via the graph-theoretic description of the Alexander polynomial due to Kálmán, and the test of log-concavity of Huh.

Keywords: manifolds,heegaard floer homology,tqft
“Microelectromechanical System wake-up receiver for Zero-Power sensor nodes” (MEMS0P)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

This project aims to design and fabricate a new fully passive microelectromechanical (MEM) wake-up receiver to be used in next-generation wireless sensing nodes. The metric for success will be to achieve the figures that are given by preliminary simulations (see later in the text). Specifically, this would be near-zero stand-by power (Psb<1 pW,DC) and ultra-low threshold power (Pth<-50 dBm,RF). Both of these values are orders of magnitude lower than what demonstrated through current state of the art WURs based on solid-state components.

Keywords: wake up radios,micro electromechanical devices,mems,piezoelectric resonators,alscn,electrostatic resonators
SDN - microgrid reSilient Electrical eNergy SystEm (SDN-microSENSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Spain,Germany,Cyprus,Norway,Greece,Bulgaria,Greece,Greece,Greece,Serbia,Bulgaria,Sweden,France,France,United Kingdom,United Kingdom,Luxembourg
Call: Cybersecurity in the Electrical Power and Energy System (EPES): an armour against cyber and privacy attacks and data breaches (H2020-SU-DS-2018, 2018)
Start date: 2019-05-01
End date: 2022-10-31
Duration (months): 42.0
Total project cost (EUR): 10100963.21
EU funding (EUR): 7992462.5
Participants: 39
Project status: CLOSED

The smart energy ecosystem constitutes the next technological leap of the conventional electrical grid, providing multiple benefits such as increased reliability, better service quality and efficient utilization of the existing infrastructures. However, despite the fact that it brings beneficial environmental, economic and social changes, it also generates significant security and privacy challenges, as it includes a combination of heterogeneous, co-existing smart and legacy technologies. Based on this reality, the SDN-microSENSE project intends to provide a set of secure, privacy-enabled and resilient to cyberattacks tools, thus ensuring the normal operation of EPES as well as the integrity and the confidentiality of communications. In particular, adopting an SDN-based technology, SDN-microSENSE will develop a three-layer security architecture, by deploying and implementing risk assessment processes, self-healing capabilities, large-scale distributed detection and prevention mechanisms, as well as an overlay privacy protection framework. Firstly, the risk assessment framework will identify the risk level of each component of EPES, identifying the possible threats and vulnerabilities. Accordingly, in the context of self-healing, islanding schemes and energy management processes will be deployed, isolating the critical parts of the network in the case of emergency. Furthermore, collaborative intrusion detection tools will be capable of detecting and preventing possible threats and anomalies timely. Finally, the overlay privacy protection framework will focus on the privacy issues, including homomorphic encryption and anonymity processes

Keywords: electrical power and energy systems
A Disruptive AntimicrobialSmart Photocatalytic Glass: A Disruptive Antimicrobial Coating for the Protection of Glass Surfaces & Designed to Tackle the Emergent Crisis of Resistant Microbes and Viruses (SPYGLASS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 2873511.25
EU funding (EUR): 1609166.0
Participants: 1
Project status: CLOSED

Kastus® is an Award-Winning surface innovation company founded in 2014 with global headquarters and manufacturing based in Ireland. Our patented range of antimicrobial (AM) and hydrophilic coatings are designed to enhance surfaces across our 2 core Industries, Glass (TRL 8) and Ceramics. In relation to the antimicrobial coatings, the technology is designed to eliminate up to 99.99% of harmful bacteria and viruses such as Corona, C. Diff, MRSA and E. Coli. Kastus® has also been funded by Atlantic Bridge (VC) to get the technology from TRL 3 to 8 and funding is now required to get to get the glass formulation to TRL 9. Kastus® needs the EIC support to accelerate the technology into full production and allow us to expand our disruptive technology offering into the entire touchscreen and glass AM sectors. We have built the momentum and the funding and support from the EIC will enable us to expand and build a global European company with forecasted revenues in 2025 of over €42m. Without the funding, the risk of losing first to market advantage is high due to the large cost needed to commercialise. Previous submission to SME Instrument in July 2019, Kastus® was awarded the Seal of Excellence.

Keywords: covid 19,corona,antimicrobial coating,antiviral coating
A Better Life for the Children of Exile: Intergenerational Adaptation of the Descendants of Refugees (REFU-GEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1406237.0
EU funding (EUR): 1406237.0
Participants: 1
Project status: SIGNED

More than 2.5 million refugees have been granted residence in Europe over the last ten years and their long-run adaptation is a fundamental societal challenge. Adaptation can only be evaluated over the long-run by making intergenerational comparisons between immigrants and their descendants, yet research has almost entirely overlooked this topic for refugees, not least because most countries lack both data and significant numbers of descendants of refugees. Prior studies focus on isolated domains of life and are limited by small-samples, methodological weaknesses, and a failure to compare the descendants of refugees and non-refugees. This proposal represents the first comprehensive intergenerational study of the descendants of refugees. My aim is to establish a new framework for the adaptation of refugee’s descendants across four domains of life: socio-economic status, health, family formation and residential context. I will use cutting-edge research methods to analyse longitudinal data for the whole population of Sweden from 1968-2019. Thanks to the unique combination of this comprehensive data, and Sweden’s long history as a refugee-receiving country, I will be able to make ground-breaking contributions: [1] To reveal the diverse nature of intergenerational adaptation for the second-generation children of refugees, and establish to what extent this is determined by their parents’ adaptation [2] To uncover the mechanisms of intergenerational adaptation for the second-generation children of refugees [3] To establish the nature and extent of intergenerational adaptation beyond the second generation, for third-generation grandchildren of refugees Answers to these questions have the potential to generate enormous gains in understanding, and establish a much-needed holistic evidence base concerning the long-run adaptation of the descendants of refugees. I will use Sweden as a laboratory to develop theories that can be generalised to other European countries.

Keywords: intergenerational adaptation,migration,refugees,demography,quantitative methods,register data
Metal-Organic Frameworks as Chemical Reactors for the Synthesis of Well-Defined Sub-Nanometer Metal Clusters (MOF-reactors)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-12-31
Duration (months): 70.0
Total project cost (EUR): 1886000.0
EU funding (EUR): 1886000.0
Participants: 1
Project status: SIGNED

Humankind advancement is connected to the use and development of metal forms. Recent works have unveiled exceptional properties –such as luminescence, biocompatibility, antitumoral activity or a superlative catalytic activity– for small aggregations of metal atoms, so–called sub–nanometer metal clusters (SNMCs). Despite this importance, the gram-scale synthesis of structurally and electronically well–defined SNMCs is still far from being a reality. The present proposal situates at the centre of such weakness and aims at making a breakthrough step-change on the use of metal-organic frameworks (MOFs) as chemical reactors for the in–situ synthesis of stable ligand-free SNMCs with such unique properties. This challenging synthetic strategy, which is assisted by striking published and inedited preliminary results, has solid foundations. Firstly, the design and large-scale preparation of cheap and novel families of highly robust and crystalline MOFs with tailor-made functional channels to be used as chemical reactors. Secondly, the application of solid-state post-synthetic methods to drive the multigram-scale preparation of unique ligand-free homo- and heterometallic SNMCs, which are, in the best-case scenario, very difficult to be obtained and stabilised outside the channels. Last but not least, single-crystal X-Ray diffraction will be used as the definitive tool for the characterisation, at the atomic level, of such ultrasmall species offering unprecedented snapshots about their real structures and formation mechanisms. The ultimate goal will be upscaling this synthetic strategy aiming at the large-scale fabrication of SNMCs and their industrial application will be then evaluated. A successful achievement of all the aforementioned objectives of this ground-breaking project would open new routes for the use of MOFs as chemical reactors to manufacture, at competitive prices, MOF-driven, structurally and electronically well–defined, ligand–free SNMCs in a multigram-scale.

Keywords: metal organic frameworks mofs,subnanometric metal clusters,heterogeneous catalysis,chemical reactors,single crystal x ray diffraction,postsynthetic methods
Artificial evolution of a novel multifunctional human polymerase (EVOPRIMPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The product of the human gene ccdc111, PrimPol, has been recently identified and characterized by the group of Professor Luis Blanco (CBMSO, Madrid, Spain). This protein is capable of performing both priming and polymerase activities in human cells, contributing to DNA integrity and maintenance during its replication. As an enzyme involved in tolerance to DNA damage, its malfunction gives rise to human diseases. Thus, it might become a target for cancer therapy. In order to exploit the benefits derived from knowledge of PrimPol, a deeper structure-function study must be done. These studies can not be accomplished using standard site-directed mutagenesis protocols and further characterization due to variety activities that this protein displays, the novelty of its discovery and the absence of a solved crystal structure. Thus, EVOPRIMPOL will be a novel, fast and reliable approach to study the role of critical amino acids involved in the different activities shown by the enzyme. This approach is based on the in vitro directed evolution of human gene ccdc111, but unlike other directed studies performed in polymerases, where genes are mutated randomly, in EVOPRIMPOL we will use a new rational design to select those residues that will be randomised; selecting them after the phylogenetic study of all members of the protein superfamily containing PrimPols as well as by homology sequence studies using different DNA polymerases and primases from other superfamilies. Chosen residues will be randomised following an iterative mutagenesis scheme, where evolved variants are subjected to new rounds of mutagenesis mimicking the natural evolution. Thus, improved PrimPols will be obtained with better catalytic properties. Biochemical study of these variants will provide us information about the role of critical residues in the control and regulation of the PrimPol activities, which might be used to generate PrimPols variants with potential biotechnological uses.

Keywords: directed evolution,protein engineering,dna polymerase
A revolutionary blood test to easily diagnose and prevent deadly complications of organs and tissue transplants. (IRIS Phase-1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Transplantations are life-saving treatments, often representing the only option for people with severe disease such as blood cancers. Unfortunately, complications linked to transplants are so high that they are current limiting the increase of adoption of transplantations. Specifically, Graft versus Host Disease occurs in up to 80% cases after receiving bone marrow from a donour and poses a serious threat to the life of patients already in critical condition. Graft versus Host Disease, today, can only be suspected when it is already at an advanced state, i.e. when clinical symptoms appear. However, symptoms are not unique, thus invasive biopsies are needed for a certain diagnosis. At this stage, even more time has been wasted before starting an effective drug treatment: the mortality risk can reach 95%, the hospitalization period lasts months instead than weeks and so drug treatments, that have to be stronger and more aggressive. MarxBio for the first time in the world was able to link a particular enzyme called GSK-3beta to the onset of Graft versus Host Disease and, specifically, to the proliferation of donor’s T-cells that attack the host. The Company has the unique knowhow to monitor the complex pathways of GSK-3beta to diagnose and monitor the progression of the disease, through the use of tens of different, specific antibodies. All of this know-how has been enclosed in a disposable protein chip, so a simple blood test, instead of a biopsy, is required to detect the disease: results can be obtained in every laboratory, with the use of a standard fluorescence scanner. Scientific results have been published and intellectual property has been protected with a patent portfolio. During Phase 1 project the Company will assess the scale-up plan and the clinical trials to be conducted to validate the diagnostic kit, and will establish a sound go-to-market strategy to ensure a swift market uptake of the proposed solution.

Keywords: graft versus host disease,advanced process,protein kit,transplant,bone marrow,hematopoietic,cell,gsk 3 beta,nano biotechnology,antibodies,diagnosis,blood cancer,t cell,clinical symptoms
Portable electrochemical assay system for on-chip quantitative estimation of bladder cancer biomarkers in real samples (BlaC E-assay)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-05
End date: 2017-10-04
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cancer is a leading cause of death worldwide and the best approaches to improve cancer survival rate is to diagnose it at an early stage. In spite of the rapid explosion of new technology platforms, traditional optical ELISA is used in clinical practice, which is laborious, time-consuming, require large sample volume and suffer from low sensitivity. On the other hand, recently proposed electrochemical sensors which promise easy operation, accuracy, high sensitivity, low cost and compact size mainly suffer from background signals, non-specificity and selectivity in clinical samples. Therefore, there is an urgent need to solve the key issues in the development of clinically relevant and commercially viable technologies that enable screening of high-risk individuals for cancer at an early stage. The proposed program is to develop a reliable point-of-care (POC) diagnostic system based on a multidisciplinary approach of integrated microfluidic and electrochemistry for multiple biomarker detection in clinical samples. The proposal aims at finding solutions for key issues of non-specificity, sensitivity and selectivity in clinical samples for sensitive and multiplexed detection. The proposal will address the above mentioned challenges, via separation of assay chamber and detection chamber with innovative surface chemistry and microfluidic design with electrochemical detection techniques. Work will be focused on bladder cancer as a test model to solve the above mentioned issues. The proposed device will be of bench top size and have capabilities to detect a panel of 3 or more biomarkers simultaneously. The successful outcome of the project will result in high impact publications, technology know-how and IP, which will be used to design and develop a prototype device. A secondment at Applied Enzyme Technology Ltd, Gwent Group (GWENT) will be used to study optimization of sensor shelf life and to ensure the developed system meets industrial standards.

Keywords: biosensors,cancer diagnosis devices,electrochemical sensors