Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Barcoding gene expression dynamics at single-molecule resolution (DYNOME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-02-01
End date: 2025-07-31
Duration (months): 66.0
Total project cost (EUR): 2368531.0
EU funding (EUR): 2368531.0
Participants: 1
Project status: SIGNED

Gene expression is an inherently stochastic process. Random expression bursts cause tremendous cell-to-cell variations in mRNA and protein levels. The consequences are beneficial in some instances, e.g., in cell differentiation, and harmful in others, e.g., in bacterial drug tolerance. A key interest in biology is therefore to decipher the kinetics that characterise this noise. What is the distribution of transcription rates in a cell population? Are gene expression dynamics heritable? Do gene networks communicate via the ‘Morse code’ of expression burst? Detailed answers to these questions are pending due to insufficient methods to temporally resolve gene expression noise at single-molecule resolution. A ‘transparent cell’ is needed for which transcription and translation kinetics is accessible for many genes in parallel. DYNOME is my answer to this challenge. DYNOME combines (i) a super-resolution detect-and-bleach strategy, (ii) multi-colour barcoding to monitor up to six genes in parallel, (iii) a lineage tracking tool, and (iv), lab-on-a-chip bioreactors to steer growth conditions. Using this innovative bio-dynamics platform, I will monitor gene expression dynamics at the single-molecule level for many genes in single cells at the same time over many generations. My targets for DYNOME are stochastic decision-making events in bacteria and in eukaryotic cells that include (i) a stochastic phenotype switch (B. subtilis), (ii) the development of non-genetic drug resistance (E. coli), and (iii) cell cycle control (S. cerevisiae). The results will reach far beyond these organisms. Decrypting cell-individuality with kinetic models will be a breakthrough both in basic and in applied sciences with impacts on the development of drugs against bacterial invasions, the design of new and useful functionalities in cells, and on our understanding of how biological variability arises from the laws of statistical physics.

Keywords: single molecule tracking,gene expression dynamics,photon counting,kinetic models
Women’s Economic and Psychological Empowerment (EMPOWER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-10-01
End date: 2024-02-03
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Women’s Economic Empowerment has become a mainstream gender and development policy and practice. UN Women states that “investing in women’s economic empowerment sets a direct path towards gender equality, poverty eradication and inclusive economic growth”. But as leading gender and development academics ask, is it really that simple? In the light of gender inequalities worldwide, feminist economists and gender and development experts, demand a more nuanced understanding of transformation processes. The Women’s Economic and Psychological Empowerment- EMPOWER project brings together feminist economics, gender and development, and social psychology to understand how to ensure personal empowerment processes through the promotion of women’s access to productive resources in specific contexts. EMPOWER will answer the research question for which women, with which economic activities and in which contexts can access to productive resources allow for economic and social transformations that lead to women’s psychological empowerment. EMPOWER aims to look at the psychological empowerment process in relation to programmes that target to give women access to different economic resources with a critical analysis of how development programmes work, engaging insight from academia as well as insights from gender and development policy. I will be hosted by CARE Netherlands, one of the major non-academic international organisations in the development sector that has an extensive database of women’s empowerment programmes with the aim of creating gender transformative change across different geographic and socio-political settings. Furthermore, I will carry out a secondment at the International Institute for Social Sciences, a major European academic institution of policy-oriented social science. The proposed research and training programme is carefully designed to advance my professional goal of becoming a researcher and policy advisor in women’s empowerment and gender equality.

Keywords: women s economic empowerment,psychological empowerment,gender equality
Commercial assessment of a novel protocol for epilepsy characterisation with temporally interfering electric fields (CONECTIF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The ERC StG project “Epilepsy Controlled with Electronic Neurotransmitter Delivery (EPI-Centrd)” is focused on improved therapeutic intervention in drug-resistant patients with surgically-complicated forms of epilepsy. These patients represent a large demographic needing new commercial solutions, as there are fifty million people in the world with epilepsy and up to 50 cases of new-onset epilepsy per 100,000 people each year, where 30% of these cases are patients with drug-resistant epilepsy. Although EPI-Centrd provides state-of-the-art treatments for epileptic zones in the brain of drug-resistant patients, it does not include technology for improved identification of such epileptic zones. This ERC PoC project “The Commercial Assessment of a Novel Protocol for Epilepsy Characterisation with Temporally Interfering Electric Fields (CONECTIF)” dramatically improves the traditional limitations in the identification of epileptic zones in the brain of patients by providing a simplified, less-invasive method capable of localizing epileptic tissue, including the ability to non-invasively investigate previously inaccessibility and surgically-complicated brain regions. The new method utilizing temporally interfering electric fields could have a massive commercial potential and, if successful, would dramatically improve the therapeutic targets for technologies developed in the EPI-Centrd project and for the identification of epileptic zones in other forms of epilepsy, not only in drug-resistant patients.

Keywords: epilepsy,electrophysiology,identification of epileptogenic zones,novel protocols in epilepsy
Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes (HYMADE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Armenia,Germany,Argentina,Austria,Spain,France,United States
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 1219500.0
EU funding (EUR): 1219500.0
Participants: 10
Project status: CLOSED

HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. The project is based on the secondments of Early Stage Researchers and Experienced Researchers and networking and training activities between European and non European academic institutions. HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. The project also aims to gain understanding of the self assembly process of hybrid materials and the transport properties of the drug delivery systems.The biological fate, drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. To achieve these goals we have gathered an international multidisciplinary team with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Biophysics and Imaging from Germany, Austria, France and Spain on the European side and from United States of America, Argentina and Armenia on the non European side.

Keywords: drug delivery,polyelectrolytes,virus like nanoparticles,transport,imaging,hybrid materials
Earth Resilience in the Anthropocene (ERA) Integrating non-linear biophysical and social determinants of Earth-system stability for global sustainability through a novel community modelling platform (ERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Sweden
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 2492834.0
EU funding (EUR): 2222267.75
Participants: 2
Project status: SIGNED

In 2015, the UN Sustainable Development Goals (SDGs) and the Paris Agreement on climate recognised the deteriorating resilience of the Earth system in the Anthropocene. Maintaining Earth in the interglacial state that enabled the world’s societies to evolve over the past 12,000 years will require industrialised societies to embark on global-scale social transformations. Otherwise, there is a real risk of crossing tipping points in the Earth system triggering abrupt and irreversible changes. A critical gap is that although nonlinear social and biophysical dynamics are recognized, we remain trapped in linear thinking. Global modelling and analyses – despite much progress – do not adequately represent nonlinear processes and abrupt changes, and social responses to sustainable development are incremental. The goal of this project is to fill this gap, by exploring the biophysical and social determinants of the Earth’s long-term stability, building up a novel community modelling platform for analysis of nonlinearity and abrupt shifts, and informing global sustainability policy processes. The project will investigate two hypotheses: 1) Interactions, feedbacks and tipping points in the biosphere could, even in the absence of continued high emissions from fossil-fuel burning, tip Earth into a new state, committing to global warming over 2C and possibly beyond 4C; and 2) Only nonlinear societal transformations that aggregate to the global scale can assure long-term stability of the Earth and keep it in a manageable interglacial state. The five research tasks are Task 1: analysis of nonlinear biosphere dynamics governing Earth resilience. Task 2: integrating nonlinear dynamics in World-Earth models. Task 3: exploring tipping points in social systems for large-scale transformation. Task 4: backcasting pathways for achieving the SDGs. Task 5: integrating World-Earth dynamics into online learning and virtual-reality games, e.g. Planet3 and Minecraft.

Keywords: earth system modelling,global sustainability science,resilience,scenarios,transformations
Detecting and quantifying CH4 emissions from scarab larvae using stable carbon isotopes (CH4ScarabDetect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The increase of the average global atmospheric methane (CH4) concentration from about 700 ppb to 1800 ppb since 1750 is the result of a global imbalance between CH4 sources and sinks. Even small changes in source or sink strength are expected to have a rapid impact on the atmospheric CH4 concentration, making CH4 an excellent candidate for short-term climate change mitigation strategies. However, this mitigation potential can only be accessed if we can accurately quantify all sinks and sources contributing to the global CH4 budget. One of the poorly understood aspects of the global CH4 budget is the effect of land-use change and soil management on the CH4 budget of soils which themselves can be either sinks or sources of atmospheric CH4. The central drawback in our understanding of the mechanisms controlling net soil CH4 fluxes is our insufficient knowledge on gross CH4 fluxes and the involved organisms. The project “CH4ScarabDetect” aims to provide the first quantitative estimate of the importance of soil-dwelling cockchafer larvae for net soil CH4 fluxes. These important European agricultural and forest pests are qualitatively known to emit CH4, but have thus far been neglected in terrestrial CH4 cycle research. To reach its aim, “CH4ScarabDetect” will develop a new non-invasive field monitoring method for separating gross CH4 production and gross CH4 oxidation in soils in general, and for detecting larvae infestations in particular, by combining for the very first time the well-known chamber flux method with a 13CH4 isotope pool dilution technique and acoustic measurements of larvae sounds. This novel approach will not only further our understanding of the role of cockchafer larvae in the terrestrial CH4 cycle and provide a new tool for soil CH4 flux and soil insect studies, but promises to also improve the monitoring of cockchafer infestations, thus generating new knowledge of major relevance for both scientific and practical reasons.

Keywords: soil methane cycle,cockchafer larvae,non invasive field monitoring,chamber method,stable carbon isotope signature
Places of Remembrance in Muslim Russia: Islamic Heritage and Moral Landscapes (MeMuRu)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 3
Project status: CLOSED

The goal of this project is to map Islamic places of remembrance in Central Russia’s Volga region, and analyse their social, political, and affective life. The post-Soviet Islamic boom has raised acute concerns and generated debates on the place of Islam in Russia, home to an ancient Muslim community. So far, little fine-grained anthropological scholarship about Russia’s Muslim population has been produced. My project seeks to fill this gap in our knowledge by looking at the concrete places where the post-Soviet Islamic revival manifests itself. The past few years have witnessed the rediscovery – sometimes reconstruction – of numerous Islamic sites throughout the Russian Federation, along with the emergence of numerous locales where self-cultivation, ethnically inflected civic engagement, conflict, and compromise are played out by Muslims through the prism of remembrance. Anthropological methods of investigation shall be utilised to analyse how both institutional initiative and grassroots creativity are involved in the production of multi-scalar moral landscapes at the intersection of the nation-state, the ethnic community, and the ummah. Special attention will be devoted to social memory dispositifs, from institutional heritage projects to intimate practices of remembering. This project, built upon specialised skills and experiences I acquired as a graduate student, will offer fresh contributions to ongoing debates on post-socialist and Islamic personhood; memory, state-Muslim relations in Russia; and the spatial manifestations of religious life amongst Eurasian Muslims. This Fellowship will give me a unique chance to complete my maturation as a social scientist. At the Universities of Berkeley and Venice, I will undertake specialised training, broadening my area expertise, my methodological repertoire, and my theoretical competencies across disciplines such as social and historical anthropology, Russian studies, and Islamic studies.

Keywords: islam in russia,islamic places of remembrance,moral landscapes and heritage,postcoloniality and postsocialism,muslim civil society in russia,volga region and tatarstan,anthropology of memory
High throughput computing for accelerated photovoltaic material discovery: From material database to the new generation of photovoltaic materials. (HT PHOTO DB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 2
Project status: CLOSED

This proposal combines synergistically the predictive power of quantum mechanical calculations with a high throughput framework for the accelerated photovoltaic material discovery. The main objective of the project is the creation of a material database that contains no crystalline-complex materials, which can be potential candidate for the development of a new generation of photovoltaic material. The robustness of the project is reinforced by the secondment of Onyx solar which will synthesis and characterize the most promising candidates to validate the methodology and optimize the process. The collaboration between ICCRAM researchers and facilities and the experience of the fellow in this multidisciplinary field guarantee the ideal conditions for the success of the research and the development of new methodologies, infrastructures and knowledge that are highly linked to the roadmap described in Horizon 2020

Keywords: material database,high throughput,photovoltaic material
Building the fully European supplY chain on RFSOI, enabling New RF Domains for Sensing, Communication, 5G and beyond (BEYOND5)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Israel,Türkiye,Belgium,Poland,Romania,Sweden,Sweden,Türkiye,Belgium,Switzerland,Türkiye,France,France,France,France,France,Netherlands,Netherlands,Netherlands
Call: ECSEL-2019-1-IA (H2020-ECSEL-2019-1-IA, 2019)
Start date: 2020-06-01
End date: 2024-02-29
Duration (months): 45.0
Total project cost (EUR): 94171544.4
EU funding (EUR): 24361637.23
Participants: 42
Project status: SIGNED

The overarching goal of BEYOND5 is to build a completely European supply chain for Radio-Frequency Electronics enabling new RF domains for sensing, communication, 5G radio infrastructure and beyond. BEYOND5 is first and foremost a technology project gathering most significant European actors covering the entire value chain from materials, semiconductor technologies, designs and components up to the systems. BEYOND5 will drive industrial roadmaps in More than Moore (MtM) in adding connectivity features on existing CMOS Technology. The ambition is to accomplish sustainable Radio Frequency SOI platforms to cover the frequency range from 0.7GHz to more than 100GHz, and to demonstrate the technical advantage of SOI, which allows combining large scale integration, low power consumption, cost competitiveness and higher reliability; thus, resulting in high volume production of trusted components with low environmental impact in Europe. This objective will be achieved in a “Time to Market” approach using the 3 major work streams: 1. Technology enhancement in three European industrial pilot lines: • 300mm RF SOI substrates pilot line in Soitec, supported by the “Substrate Innovation Center” in CEA LETI to prepare future generations. • RF-SOI 65nm pilot line for 5G FEM in ST addressing both sub-6GHz and 28GHz domains. • 22FDX pilot line addressing Digital Signal Processing of radio module and RF reliability, in GF 2. European RF design ecosystem strengthening, based on a large fabless community using FD-SOI and RF-SOI platforms 3. Six Leading edge systems aggregating the value chain to demonstrate added-value of the technology at the user level: • NB IoT for Smart Asset Tracking, • Contactless USB for high-data rate communication, • V2X for autonomous connected trucks, • 5G Low Power Digital Beamforming Base Station for Indoor dense spaces, • Automotive MIMO Radar with embedded AI, • Car Interior Radar for passenger monitoring.

Keywords: silicon on insulator,fdsoi,rfsoi,energy efficiency,power consumption,radio frequency domains,millimeter wave connectivity,low power,cmos radar