Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VISUALIZATION OF TOPOLGICAL STATES IN PRISTINE NANOWIRES (TOPO-NW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: CLOSED

Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass lower dimensional topological systems. The main reason is surface contamination which is disruptive both for STM and for the fragile electronic states. We propose to study topological states of matter in pristine epitaxial nanowires by combining growth, fabrication and STM, all in a single modular ultra-high vacuum space. This platform will uniquely allow us to observe well anticipated topological phenomena in one dimension such as the Majorana end-modes in semiconducting nanowires. On a broader view, the nanowire configuration intertwines dimensionality and geometry with topology giving rise to novel topological systems with high tunability. A vivid instance is given by topological crystalline insulator nanowires in which the topological symmetry protection can be broken by a variety of perturbations. We will selectively tune the surface states band structure and study the local response of massless and massive surface Dirac electrons. Tunability provides a higher degree of control. We will utilize this to realize topological nanowire-based electronic and spintronic devices such as a Z2 pump and spin-based Mach-Zehnder interferometer for Dirac electrons. The low dimensionality of the nanowire alongside various singularities in the electronic spectra of different topological phases enhance interaction effects, serving as a cradle for novel correlated topological states. This new paradigm of topological nanowires will allow us to elucidate deep notions in topological matter as well as to explore new concepts and novel states, thus providing ample experimental prospects.

Keywords: topological insulators,topological crystalline insulators,nanowire,majorana
TRUck Suistanable Transport - Innovative project for management of Contract Logistics (TRUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FOOD WASTE is a significant problem. The United Nations Food and Agriculture Organization estimates that one third of human food production is lost or wasted globally for around 1.3 billion tonnes per year. A relevant part of the waste originates upstream in the supply chain and COLD CHAIN (temperature controlled supply chain of perishable goods) plays a pivotal role in the distribution process as it preserves and extends the shelf life of various products. As an answer to the increasing demand for an Europe-wide transport solutions which are able to guarantee product integrity, TRUST platform provides an INTEGRATED COLLABORATIVE ecosystem to the OPERATORS involved in transporting temperature sensitive products, both production companies with delivery monitoring needs and transport services supplier. TRUST project have the aim to make available an INNOVATIVE complete solution that overtakes the fragmented nature of the products available today by integrating best-in-class components for the specifics processes into a modular environment to cover the market’s requirement for the cold chain sector: ROUTE PLANNING and optimization, MONITORING and control of delivery, transport’s QUALITY CERTIFICATION. In Europe, over 400.000 companies operate in logistic sector and TRUST solution is targeting medium and large companies with a FLEET BIGGER THAN 50 vehicles. Strong economic environment and augmented global trade are predominantly driving the cold chain market and the market addressed for TRUST initial exploitation will be FRANCE, ITALY, SPAIN and POLAND, some of the key contributors to the cold chain market in the region, with a total of over 2.200 targeted companies. The feasibility assessment of the overall TRUST innovation project will be: 1. To validate MARKET ACCEPTANCE of the product by carrying out an extensive study 2. To define the BUSINESS and INNOVATION PROGRAM. 3. To carry out the required improvements for FINAL DISTRIBUTION of the solution on the market.

Keywords: cloud web based application,cold chain,temperature controlled supply chain in real time,food sectors,smart ict solution,truck exchange,charge bays,design of optimal routes
Plastic nanoscale electronics via novel fabrication paradigms (A-LITHIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Nanogap electrodes have been a highly attractive research area for over 25 years. This is mainly due to their potential for realising next generation nanodevices and circuit elements with lower power consumption, faster speed, and higher level of integration, as well as investigating the fundamental properties of materials at the nano- or even molecular level. However, the lack of a facile, inexpensive, high throughput technique for the manufacturing of dissimilar nanogap electrodes has hindered their commercial and scientific exploitation. It is exactly at this junction that I strive to make significant advances with this proposal, by first implementing a novel patterning technique, adhesion lithography (a-Lith), to manufacture large aspect ratio (>100,000) metal electrode nanogaps (<50 nm) on a variety of substrates and then by fabricating and fully characterising nanoscale devices that will allow both understanding of the relevant device physics, alongside, advancing in device performance. Herein, I will firstly further develop the a-Lith key processing steps in order to establish a reliable protocol for the controlled geometry and uniform nanogap formation. Then I will follow a multidisciplinary research trajectory aiming at the development of high performance co-planar nano-scale electronic devices. Targeted proof-of-concept applications include radio frequency rectifying Schottky diodes, non-volatile ferroelectric tunnel junction memories, light-emitting diodes (LEDs), photodetectors, piezoelectric nanogenerators and molecular nano-junctions, the architectures and dimensions of which would be difficult or far too expensive to obtain with traditional patterning techniques (e.g. e-beam lithography). Finally, during my secondment, I will pursue the successful demonstration of fully functional non-volatile ferroelectric tunnel memory array over large area flexible substrates that will pave the way to the industrial deployment of this highly promising technology.

Keywords: nanofabrication,oleds,ferroelectric tunnel junctions,photodetectors
Simulation of metal Solidification in Additive Manufacturing processes (SimSolidAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-15
End date: 2019-03-14
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The project is aimed to the enhancement of numerical simulation tools for the Additive Manufacturing process, focusing on analysis of temperature evolution and solidification behaviour of material during the Metal Deposition process. A novel approach to the thermal FEM simulation of Metal Deposition processes is proposed, with the implementation of an innovative solidification model in COMET (a Finite Element (FE)-based framework for the solution of engineering problems). The proposed solidification model directly describes the evolution of solid fraction in function of time and depend from some empirical parameter. Examples of simplified AM processes will be studied in order to calibrate the model and evaluate advantages in terms of CPU costs and accuracy. Dedicated semi-empirical models for evaluation of local microstructures in function of temperature history of metal during the AM process will be also developed, implemented and experimentally calibrated. Mechanical properties will be evaluated by means of direct empirical correlation with local microstructures. Finally, real cases of complete AM processes will be studied in order to validate the overall AM simulation tool. The final objective is to develop an innovative, useful and quick simulation tool for the optimization of the AM process. End users such as software houses and mechanical industries are strongly interested the enhancing of simulation accuracy and CPU time. The impact of process optimization in terms of time, cost and product quality leads to clear benefits not only for end-users but also for society in general.

Keywords: process simulation,additive manufacturing,metal deposition,solidification,microstructures,mechanical properties,process optimisation,quality control
Collagen in Cancer: from the regulatory fibril forming function of collagen V in development to its implication in tumor progression (CoCa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Molecular mechanisms that determine survival, differentiation and movement in multicellular organisms depend on extracellular matrix (ECM) integrity and cells interacting with the ECM. Collagens are the most abundant proteins in the ECM. Their primary function is to provide structural support to cells and to maintain biomechanical integrity of tissues. However, collagens are not just structural proteins. They act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. It’s increasingly important to understand these mechanisms in cancer biology. Disruption or imbalance in collagen dynamics is associated to tumor formation and progression by directly acting on the development of tumoral stroma, cancer-associated fibroblasts and angiogenesis. Hence, targeting aberrant ECM may provide an effective avenue to combat cancer. Fibrillar collagens are among the first components to be compromised in cancers. This research proposal focuses on the role of the regulatory fibril forming collagen V whose upregulation has been reported in several types of human tumors. Combining my skills in cancer biology with the expertise of the host lab in ECM biology, I will investigate the versatile regulatory roles of collagens in ECM dynamics. I will focus in particular on the formation of the tumoral microenvironment and the complex mechanisms by which the properties of ECM instruct the development of cancer.
Industrial implementation of adaptive computational methods for turbulent flow and fluid-structure interaction (ADAPTIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 146897.0
EU funding (EUR): 146897.0
Participants: 1
Project status: CLOSED

The ERC StG project UNICON (Project ID 202984) was completed in July 2013. The goal of UNICON was to develop new adaptive finite element methods for computer simulation of fluid-structure interaction, in particular for problems involving turbulent flow. Simulation of turbulent flow is an outstanding computational challenge, where the UNICON project made significant progress beyond the state of the art. The scientific results of the UNICON project include a new theoretical and methodological framework, and a computer implementation of the methods as open source software, published as part of the FEniCS project, co-founded by the PI (Hoffman) in 2003. FEniCS is today a world leading open source software for computer simulation based on differential equations, with an estimated 50 000 downloads per year, and the PI today leads the PRACE Tier-0 project FEniCS-HPC, in which algorithms and software are developed for the most powerful supercomputers in Europe. Compared to competing simulation software, free as well as commercial, UNICON computational technology has proven to exhibit unique features with respect to accuracy and efficiency. The idea of this ERC PoC project is to commercialize the UNICON simulation technology. In particular, ADAPTIVE targets civil (non-military) industry, with a focus on subsonic fluid dynamics. The strategy is to deliver services and products tailored to each customer, from deliverance of a simulation result, to education and support for integration of the simulation tools in the workflow of a customer.

Keywords: adaptive finite element method,turbulent flow,fluid structure interaction,industrial application,open source software
Regeneration of the adult zebrafish brain (ZF-BrainReg)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The goal of this research proposal is to unravel the cellular and molecular mechanisms for the ability of the adult zebrafish brain to regenerate itself after a lesion, and to compare these mechanisms in the non-regenerating mammalian brain. The corresponding mechanisms, if reactivated, may rekindle regeneration also in mammalian brains. Specifically, we focus on identifying the endogeneous stem and progenitor cells that contribute to neural regeneration in zebrafish, by genetic lineage tracing experiments under conditions of regeneration. We have begun to identify the genes and mechanisms controlling regeneration ability in these cells by transcriptome analysis of specific cell types isolated by FACS sorting and transcriptome analysis, which has revealed a key positive role for inflammation as a trigger in regeneration. The resulting candidate genes are functionally tested in adult zebrafish brains for their requirement and sufficiency to elicit or contribute to brain regeneration. If confirmed, we will test for the function of such genes and mechanism in mammalian tissue culture models of regeneration, and determine in adult mouse brain in vivo whether they are candidates to be tested in mammalian brain regeneration. Functional knock-out, knock-in and viral expression tests of such genes and mechanisms in vivo in mice will determine their ability to rekindle regeneration in the lesioned mammalian brain. This research proposal will provide fundamental insights into the cellular and molecular mechanisms controlling the process of brain regeneration in vertebrates, and will thus suggest avenues for future progenitor cell-based therapies of the injured or diseased human brain.

Keywords: regeneration,zebrafish
Virocellular hybrids and epigenomic changes as driving factors of infection driven cancers. (METHYVIREVOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-14
End date: 2021-03-13
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Human Papillomavirus (HPV) is the cause of the most common sexually transmitted diseases that the majority of adults will contract during their lifetime. Although most HPV infections are cleared by the immune system within several months, persistent HPV can lead to severe cancers of the oropharynx and anogenital tract. Consequently this DNA virus is a major public health burden accounting for 5% of all cancers worldwide and 7.5% of all female cancer deaths yearly. It is well established that both viral and host genomes undergo significant epigenetic changes during the infectious process. However, the link between the genomic status of the HPV (episomal or integrated), the aberrant methylation patterns of cancer cells and the disease severity remain poorly understood. In addition, the early stages of HPV infection are less studied and viral DNA methylation changes during the progression towards persistent infection is largely unknown. This proposal aims to tackle both problems. In the first workpackage, I will use the publically available data generated by The Cancer Genome Atlas project to study methylation status of the HPV genome focusing in particular on a newly identified HPV-human hybrid episomes. Recently discovered in oropharynx cancer, the biological impact of this form of HPVs on cervical cancer development and the clinical outcome have never been characterized so far. In the second workpackage, I will be using a novel and unique longitudinal clinical study, developed by the host laboratory, following young women infected with HPV. This original data will allow me to decipher DNA methylation changes occurring during the early stage of the HPV infection and their role in disease progression. Together, the data and discoveries generated from this project will answer clinically-relevant questions that will allow the development of new diagnostic approaches of HPV-associated cancers.

Keywords: human papillomavirus,dna methylation,cervical cancer,the cancer genome atlas,human hpv hybrid episome
X5gon: Cross Modal, Cross Cultural, Cross Lingual, Cross Domain, and Cross Site Global OER Network (X5gon)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Slovenia,Slovenia,France,United Kingdom,United Kingdom
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-09-01
End date: 2020-12-31
Duration (months): 40.0
Total project cost (EUR): 3120957.5
EU funding (EUR): 2995145.0
Participants: 8
Project status: CLOSED

The proposal X5gon stands for easily implemented freely available innovative technology elements converging currently scattered Open Educational Resources (OER) available in various modalities across Europe and the globe. X5gon combines content understanding, user modelling quality assurance methods and tools to boost a homogenous network of (OER) sites and provides users (teachers, learners) with a common learning experience. X5gon deploys open technologies for recommendation, learning analytics and learning personalisation services that works across various OER sites, independent of languages, modalities, scientific domains, and socio-cultural contexts. It develops services OER media convergence including full courses, course materials, modules, textbooks, videos, tests, software, related events, tools, materials, techniques used to support access to knowledge. Fivefold solutions are offered to OER sites: • Cross-modal: technologies for multimodal content understanding; • Cross-site: technologies to transparently accompany and analyse users across sites; • Cross-domain: technologies for cross domain content analytics; • Cross-language: technologies for cross lingual content recommendation; • Cross-cultural: technologies for cross cultural learning personalisation. X5gon collects and index OER resources, track data of users progress and feed an analytics engine driven by state-of-the-art machine learning, improve recommendations via user understanding and match with knowledge resources of all types. The project will create three services X5oerfeed, X5analytics and X5recommend and run a series of pilot case studies that enable the measurement of the broader goals of delivering a useful and enjoyable educational experience to learners in different domains, at different levels and from different cultures. Two exploitation scenarios are planned: (i) free use of services for OER, (ii) commercial exploitation of the multimodal, big data, real-time analytics pipeline.

Keywords: open educational resources,machine learning,cross site,cross domain,cross modal,cross language,cross cultural,cross social,adaptive learning,policy making