Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification and manipulation of factors that control Shigella flexneri entrapment in septin cages. (CAGECONTROL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Shigella is a Gram-negative bacterial pathogen and causative agent of bacillary dysentery (also called shigellosis). Shigella kills ∼164 thousand people per year and is recognised by the WHO as a priority pathogen due to the emergence of antibiotic resistant strains. In the laboratory, Shigella is an important model organism used to study cellular microbiology and host response to infection. This proposal will innovate approaches to discover factors underlying the entrapment of Shigella in “septin cages”, a host defence mechanism discovered by Prof. Mostowy. Septins are highly conserved GTP-binding proteins that polymerize into cage-like structures to entrap actively dividing intracellular Shigella, preventing their division and actin-based motility. Here, I will identify and study new host and bacterial factors underlying the formation of septin cages in HeLa cells. For this, I will use a proximity biotinylation assay (split APEX2) specifically localized at sites of Shigella-septin association, followed by mass spectrometry. I will then investigate the identified candidates by siRNA and CRISPR/Cas9 depletion in the case of the host, and by homologous recombination in the case of the bacteria, to monitor the number, morphology and dynamics of septin cages using high-content microscopy. In addition, I will do GFP-fusions to analyse the subcellular localisation of the candidates by high-resolution microscopy. Finally, to control the fate of intracellular Shigella, I will manipulate septin cage formation using nanobodies to artificially deliver septins (and other septin caging factors identified by mass spectrometry) to the surface of Shigella during infection. It is expected that my research will discover fundamental mechanisms underlying the entrapment of Shigella in septin cages, and illuminate issues central to both cell and infection biology. Moreover, my project may translate to human health impact, inspiring new treatments against shigellosis.

Keywords: apex2,autophagy,high content imaging,host pathogen interactions,infection,nanobodies,shigella,septin cage,septins
Smart Hybrid Multimodal Printed Harvesting of Energy (SYMPHONY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Germany,Austria,Germany,Austria,Germany,Sweden,Sweden,France
Call: Smart materials, systems and structures for energy harvesting (RIA) (H2020-NMBP-ST-IND-2019, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 6817527.5
EU funding (EUR): 6817527.5
Participants: 15
Project status: SIGNED

The 21st century has been dominated by an ambient digitalization, a trend that is mirrored by the use of catchwords such as Smart Energy, Smart Homes & Smart Cities and the increasing use of electronics in everyday objects. Current IoT scenarios expect a number of around 75 billion connected devices by 2025, and the powering of these devices by batteries will result in a considerable amount of potentially hazardous waste. The spread of electronic systems in remote locations should thus be accompanied by a change in power generation, making use of dislocated and disordered energy sources. A cost-efficient and environmentally friendly realization of energy harvesting (EH), however, is still a challenge, as the required input of functional material and electronic components in comparison to the energy output is high and often involves lead-based materials, manufacturing methods that consume high amounts of energy and costly assembly steps. SYMPHONY aims for the development of new materials for low-cost and scalable printing and structuring processes to fabricate multimodal EH solutions based on the ferroelectric polymer P(VDF-TrFE) as well as printed energy storage devices and rectifiers not using rare elements and heavy metals. The hybrid integration of these devices on flexible films with low power harvesting ICs will result in a specific cost below 1€/mW (well below the value for piezoceramic and electrodynamic EH). The reduction of hazardous waste and energy consumption in SYMPHONY starts with material selection and manufacturing, but ultimately unfolds its full potential in the most CO2-relevant application areas: renewable energy generation, room heating/cooling and mobility. The innovative EH concept of SYMPHONY used to power distributed sensor nodes will reduce emissions by 50% increasing the efficiency of wind turbines (Smart Energy), making room heating/cooling 20% more efficient (Smart Home) and supporting the transformation of urban mobility (Smart City).

Keywords: energy harvesting,piezoelectric,printed electronics,polymer batteries
Smart and flexible heat and power from biomass derived liquids for small-scale CHP application (SmartCHP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Belgium,Belgium,Greece,France,Netherlands,Netherlands,Netherlands,Denmark
Call: Developing solutions to reduce the cost and increase performance of renewable technologies (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 4042455.0
EU funding (EUR): 4042455.0
Participants: 11
Project status: SIGNED

The objective of SmartCHP is the realization of a cost-effective and flexible energy system by using a liquid bio-energy carrier to fuel an efficient diesel-engine based CHP. It will develop a smart and flexible, small-scale CHP unit (100-1,000 kWe) fueled with fast pyrolysis bio-oil originating from different types of biomasses and/or residues. Fast pyrolysis converts biomass into a uniform liquid intermediate called FPBO, and the process is characterized by a high feedstock flexibility. Nowadays, FPBO is produced on commercial scale in Europe. For small scale biomass CHP systems a standardized fuel, enabling optimization of the conversion units and thus creating a cost competitive value chain, is highly preferred. Moreover, to achieve high resource efficiencies at all times a highly flexible ratio between heat and power generation is desired. A smart, demand driven unit should be capable of dealing with the fluctuating energy demand and/or varying availability of wind/solar power. The SmartCHP system combines a FPBO fueled engine and flue gas boiler to produce electricity and heat at a high efficiency over the whole load range. A dedicated flue gas treatment guarantees low emissions. Moreover, a wide, adjustable heat-to-power ratio is covered which enables to respond directly to actual energy demands. The final result of SmartCHP is an integrated system consisting of an engine, boiler and flue gas treatment system adapted and optimized to run on FPBO (TRL 5). A real-time, predictive, dynamic model will be developed to find the optimal operation point at all energy demands. Techno-economic, socio-economic and environmental assessments will be performed to identify real market opportunities. The SmartCHP unit will be based on standard diesel engines, and specific investment costs are expected to be around 1,200 Eur/kWe; an electricity price below 0.10 Eur/kWh is realistic. Several case studies will be presented to illustrate the opportunities throughout Europe.

Keywords: renewable electricity and heating,biomass intermediates
A dedicated postdoctoral research and training programme fostering impact development and entrepreneurship (IMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Belgium
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2942400.0
EU funding (EUR): 1471200.0
Participants: 1
Project status: SIGNED

BROADER CHALLENGE Europe is currently facing several challenges in its R&I landscape. Studies have shown that the European Union is struggling to keep up in the global race for innovation, and that stronger collaborations between academia, business and civil society are needed to counter this trend. Consequently, the future of innovation leadership in the EU goes hand in hand with knowledge and technology transfer. In addition to this observation, research focusing on the practices of TTOs has identified an underexplored opportunity in knowledge and technology transfer, i.e. the inclusion of postdoctoral researchers in the process. Postdocs can have tremendous potential in triggering economic and social impact, while training in knowledge and technology transfer can significantly expand their career development. OVERALL OBJECTIVE With imπACT, VUB wants to address these challenges on a local scale, by deploying a postdoctoral research and training programme fostering impact development and entrepreneurship. We will deliver 20 postdoctoral researchers equipped with the necessary knowledge and technology transfer skills to take up leadership positions in academia, business and civil society and to deploy intersectoral solutions the European R&I landscape so much needs. This overall objective will be met through a set of specific objectives focusing on the development and implementation of the imπACT structure, more specifically on: - The recruitment of postdoctoral fellows - The impact- and entrepreneurship-driven research - The dedicated training programme fostering impact development and entrepreneurship - The dissemination, exploitation and communication activities

Keywords: postdoc programme,research and training,entrepreneurship
A GLOBAL THEORY OF REFLEXIVE DEBT (DELIBERATION) (RESOLVENCY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1492348.0
EU funding (EUR): 1492348.0
Participants: 1
Project status: SIGNED

Modern capitalism is essentially built on the institution of debt. The unlimited conception of debt reinforces an infinite growth logic and drives economic, political, cultural and ecological unsustainability. A crucial research question is how to constitute debt as more sustainable socio-economic medium. The RESOLVENCY project aims to shape a new (socially) reflexive debt paradigm by rethinking insolvency law as reflexive (democratic) debt deliberation. The project intends to set up a global theory of debt deliberation (for firms, consumers and states), which outlines a new RESOLVENCY paradigm for insolvency law reintegrating over-burdened debtors into the economic system (making them ‘re-solvent’) and incorporating other social (political, cultural, ecological) perspectives. ‘Resolving’ debt conflicts requires a collective procedure including debtor, creditors and all other private (employees, inhabitants) and public (communities, environment) interests involved. Advancing PI’s novel ‘discursive normative grammar’ (DNG) methodology and combining it with empirical methods, the project has four main objectives: (A) to reconstruct a universal argumentative frame (an insolvency DNG) for debt deliberation integrating normative principles (values) from corporate, consumer and sovereign insolvency theories across different jurisdictions; (B) to newly classify insolvency laws worldwide with a global comparative insolvency law theory based on this DNG; (C) to model and experiment with legal designs of reflexive debt deliberation procedures (RESOLVENCY law); and (D) to outline a model of reflexive debt (RE:DEBT) and analyse its ex ante effects on credit markets. The project does not only impact any legal and economic research on insolvency, but also debt theory in all social and sustainability sciences. In advancing PI’s DNG method, it enhances general understanding of deep normative architectures of legal reasoning and its constitutional effects for society at large.

Keywords: comparative insolvency law,debt theory,discourse theory,discourse analysis,systems theory,legal institutionalism,varieties of capitalism,law and development,heterodox economics,critical legal studies,sustainability science,sustainable debt
Geometry of Grassmannian Lagrangian manifolds and their submanifolds, with applications to nonlinear partial differential equations of physical interest (GEOGRAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Poland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

The aim of GEOGRAL is to strengthen the bonds of the geometric theory of nonlinear PDEs (and, in particular, integrable systems and equations of Monge-Ampère type) with the geometry of Lagrangian Grassmannians and their submanifolds. In spite of the evident parallelism between these two disciplines, attempts have been rare, yet sophisticated, to cast a bridge between them, and the Applicant himself already gave his own contribution in this direction: he clarified the structure of the space of non-maximal integral elements of the contact planes in jet spaces and studied 3rd order Monge-Ampère equations (which turn out to be of key relevance in topological field theories) through the so-called meta-symplectic structure on the 1st prolongation of a contact manifold. GEOGRAL has a wide applicative scope, as its theoretical results can be tested on equations and variational problems of key importance for Natural Sciences, Technology and Economy. Tailored to the Applicant's scientific profile and designed in continuity with his previous and current research activities, GEOGRAL consists of four research lines: [MOV] Regard Lagrangian Grassmannians as homogeneous spaces and and use Cartan's method of moving frame to classify their submanifolds, as in D. The's work, and characterise the corresponding invariant equations, in continuity with D. Alekseevsky's work. [HYD] Continue the study of certain rational normal curve bundles on Lagrangian Grassmannians, and their bisecant varieties, which are associated with integrable systems of hydrodynamic type, discovered by E. Ferapontov. [HMA] Geometric study of multi-dimensional and higher-order Monge-Ampère equations, initiated by G. Manno and the Applicant. [FBV] Study some examples of Cauchy problems and variational problems with free boundary values by exploiting the geometric structures on the spaces of isotropic flags and non-maximal isotropic elements of a meta-symplectic space, in continuity with the Applicant's own work.

Keywords: hypersurfaces in lagrangian grassmannian,monge ampe re equations,prolongations of contact manifolds,characteristics of pdes,distributions on manifolds
Observing Emergence (OBSERVE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany
Call: Coordination and Support Activities (H2020-FETOPEN-2014-CSA, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 410093.75
EU funding (EUR): 410093.75
Participants: 1
Project status: CLOSED

In line with the mission of the FET programme the overarching aim of OBSERVE is to support Europe to grasp leadership early on in new and emerging technology areas that promise to renew the basis for European competitiveness and growth and that will make a difference for society in the decades to come. For this purpose OBSERVE addresses the concrete objective of identifying new opportunities and directions for interdisciplinary research towards new and visionary technology of any kind. More specifically OBSERVE will: • Implement a bottom-up Horizon Scanning process using four different and complementary screening methods that will yield a set of emerging topics. • Combine this process with a broadly based participatory multi-stakeholder dialogue in a tailored sequence of face to face anticipatory dialogues which will result in a list of candidates for “Hotspots” i.e. potential topics for “new opportunities and directions for interdisciplinary research towards new and visionary technology of any kind” thus ensuring exploration of radically new avenues on the one hand and sensitivity to society’s needs on the other. • Provide a 360 degree view on both hard and soft aspects embracing all technology areas in line with the new mission of FET for H2020 with providing a clear set of novel “Hotspots” per observation phase. • Establish a rolling process that can be extended throughout H2020 or further by carefully documenting the methodology, lessons learned and concluding recommendations. • Harness the wealth of information incorporated in the FET project portfolio and community as one pillar of the scanning process thereby providing an structured overview of the FET portfolio. • Ensure a maximum of uptake of both the “Hotspots” identified and the observatory methodology, to strengthen futures literacy, responsiveness and resilience for diverse actors across Europe

Keywords: horizon scanning,emerging topics,foresight,scientometrics
Fault Tolerant Aileron Actuation System for Regional Aircraft (TAIRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Czechia,United Kingdom
Call: Aileron Actuation Subsystem using EMAs (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-04-01
End date: 2021-12-31
Duration (months): 57.0
Total project cost (EUR): 1709303.75
EU funding (EUR): 1196452.63
Participants: 2
Project status: CLOSED

The project TAIRA (Fault Tolerant Aileron Actuation System for Regional Aircraft) will deliver a highly innovative, cost-efficient, fault-tolerant, easy to maintain, safe and lightweight Electro-Mechanical Actuation system for the ailerons of regional aircraft, in full compliance to the Call requirements. In fact the project will offer the Topic Manager the chance to influence the selection out of two design strategies, with one of them offering an unprecedented level of robustness. Both solutions will combine Honeywell’s 60 years of EMA design and manufacturing know-how with its extensive expertise in Prognostics and Health Monitoring systems and Flight Control systems design and integration. This will guarantee not only a credible path to TRL5, but also an inherent certainty of product robustness, high aircraft dispatch availability, low maintenance costs, and minimum life cycle costs. Together with well-considered material choices, we are sure to offer a technology that is not only good for business but also for the environment (considering spare parts stocks, scrap value and high recycle-ability). The eventual TAIRA EMA will be manufactured in the Czech Republic and the UK, and will allow achieving up to 4% specific fuel consumption reduction on the aircraft level, thanks to the effective implementation of the More Electric Aircraft concepts. Considering the high levels of robustness, the jam-tolerant and environment-friendly design, exceptional component reliability (80.000 flight hours) and the low production cost, we are sure that this project will help driving the competitiveness of the European industry.

Keywords: electro mechanical actuator,aileron,fault tolerant,highly innovative,cost efficient,predictive health monitoring,easy to maintain,light weight,robust,compact
Manufacturing process for ultimate performance inertial MEMS Gyroscope (MUPIA) (MUPIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Norway,France,United Kingdom
Call: Manufacturing process for ultimate performance inertial MEMS Accelerometer (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-05-31
Duration (months): 39.0
Total project cost (EUR): 1330318.75
EU funding (EUR): 1235723.13
Participants: 3
Project status: CLOSED

The main objective of the MUPIA project is to demonstrate a cost-efficient manufacturing process for a high end MEMS gyroscope for aerospace Applications. Both the sensor element and the packaging process is critical to achieve a precise, long term stable and reliable component. The consortium consist of SINTEF and Cerinnov, which together with sub Suppliers cover both the necessary silicon MEMS processing and the high end ceramic packaging technology needed to reach the goal of the project. SINTEF has worked with industrialisation of MEMS components since the 1960s. Despite being a research industry, SINTEF holds the certifications ISO 9001:2015, ISO 14001:2015 and OHSAS 18001:2007 and have a regular production of MEMS components for the petroleum, medical and aerospace industry. Cerinnov has expertise in laser processes for ablation and sintering. They will collaborate with a sub Suppliers with the development of the package for the gyroscope.

Keywords: mems,accelerometer,high end,aerospace