Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effects of contaminants on seabirds: an energetics approach (ECOSEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-12-04
End date: 2019-12-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The pace of change in the World oceans is ever quickening. For instance, increasing quantities of contaminants are found in marine food webs, exposing top predators to high doses of them through food ingestion. Contaminants decrease fitness in vertebrates, but the underlying mechanisms are poorly understood, which limits the ability to predict potential long-term effects on their populations. Contaminant accumulation is thought to impose direct and indirect costs to vertebrates, through increased energy demands for detoxification mechanisms, or disruption of energy metabolism. Other impacts could be mediated via increased susceptibility to disease. Yet, the energetic consequences of contaminants on vertebrates have been largely neglected in wild animals, especially in combination with disease. This project will quantify the effects of natural (mercury, Hg) and man-made (perfluorinated compounds, PFCs) contaminants on the energy expenditure of a seabird species that frequently suffers from severe infections of gastro-intestinal parasites: the European shag. Hg and PFCs concentrations will be measured in blood of individuals with different parasite loads, and their free-ranging energy expenditure quantified using miniaturised data loggers. This project is the first mechanistic investigation of the potentially interactive effects of contaminants and disease on energetics of free-living seabirds. My knowledge in ecotoxicology, together with expert mentorship of the Host and Partner Organisations in seabird bioenergetics and parasitology, will guarantee high-quality results. The combination of cutting-edge techniques in bioenergetics and parasitology with ecotoxicology will greatly enhance my research profile. This multidisciplinary project is highly relevant for the EU Marine Directive and is a priority under Horizon 2020. Ultimately, it will disentangle how contaminants may act in association with disease and impact animal populations through a hidden energetic cost.

Keywords: mercury,perfluorinated compounds,bioenergetics,energy expenditure,stable isotopes,parasitism,disease,biologging,phalacrocorax aristotelis
Engineering of a minimal bacterial therapeutic chassis (MYCOCHASSIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 2454522.0
EU funding (EUR): 2454522.0
Participants: 1
Project status: CLOSED

Engineering bacteria to deliver therapeutic agents or to present antigens for vaccination is an emerging area of research with great clinical potential. The most challenging issue in this field is the selection of the right bacteria to engineer, commonly known as “chassis”. The best chassis depends on the application but there is a common drawback in bacteria used nowadays: their complexity and the lack of quantitative information for many reactions which limits genome engineering to classical trial and error approaches. In this project, we want to engineer the genome-reduced bacterium M. pneumoniae using a whole-cell model that will drive the rational to create a chassis for human and animal therapy. Its small size (816 Kbases), the lack of cell wall, and the vast amount of comprehensive quantitative –omics datasets makes this bacterium one of the best candidates for chassis design. By combining bioinformatics, -omics, and biochemistry approaches with genome engineering tools, systems biology analyses, and computational whole-cell models, MYCOCHASSIS aims to: i) develop a whole cell-model based on organism-specific experimental data that will be validated experimentally and that can predict the impact of genome modifications; ii) implement genome engineering tools to delete non-essential pathogenic and virulent elements predicted by the whole-cell model to engineer a therapeutical chassis; iii) using the whole-cell model design and engineer genes and circuits to improve growth rate in a defined medium. iv) as a proof of concept introduce orthogonal gene circuits to secrete peptides and enzymes capable of dissolving in vitro biofilms made by the lung pathogens Pseudomonas aeruginosa and Staphylococus aureus. This project will validate the usefulness of whole-cell models for synthetic biology by modelling multiple genomic modifications orientated to facilitate engineering of biological systems.

Keywords: minimal cell,therapeutic chassis
A groundbreaking no contact, roll to roll, modular transportation and fluid delivery technology that enables faster and more uniform chemical reaction of any feature size without risk of damage. (Fluid Foil)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A major problem with current chemical processing tools is that they use rollers to transport and support foil (any thin roll-to-roll substrate) through chemical treatment chambers located between un-winding and re-winding mechanisms. Roller transport limits and potentially prohibits fine detail treatment and reduces yield (to 10% in extreme cases) due to damage caused by contact with such rollers. Current technology employs long process tanks and slow speeds to minimise contact damage. In applications where contact is of less concern rollers still limit capability as the force required to turn them results stretching or breaking of the foil limiting foil type, thickness, and process residence times. Fluid Foil will provide frictionless, non-contact, modular transportation and fluid delivery technologies that enable chemical processing of any feature size without risk of damage to the web. Extremely low re-wind tensions enable processing of thin delicate and porous materials. Web processing density of 30 meters of web per linier meter of system dramatically increases processing speeds and most importantly places no limit on web length. Modular control software will complete activities such as data logging and real time fault analysis. Fluid Foil will have the capacity to accelerate innovation printed, organic & flexible electronics as well as enabling potential new markets to emerge (e.g. graphene, e-textiles and paper products). This will be achieved via the provision of low cost and adaptable machinery to fabricators, opening up chemical processing to SMEs. The commercial aim of the project is to limit the time-intensive work that goes into the customisation of machines and software and reduce the lead time and cost to the customer while increasing our output.Our goal for the overall project is to develop and build a suite of demonstrator modules which will help generate customer confidence and gain orders from early adopters before we go on to license the system.

Keywords: chemical,processing,rollers,modular,reel to reel,transportation,machines,flexible,circuits
Neutrinos at High Energies: Disentangling Galactic and Extra-galactic components (nuHEDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

In 2013 the IceCube South Pole Neutrino Observatory has received the Physics World award for the Breakthrough of the Year for the first observations of high-energy cosmic neutrinos. The discovery, indeed, represents the birth of a new research field, the neutrino astronomy, that can definitively shed light on the sources of high-energy cosmic-rays and on the mechanisms through which they are produced. The origin of all of the detected neutrinos is still to be correctly identified. Just recently evidence for emission from the direction of the blazar TXS 0506+056 has been reported. The most important point to understand is if the neutrino events are all of extra-galactic origin or a galactic component is present, and which are the specific characteristics, like size of the acceleration region and magnetic field, of the possible sources. To achieve this goal a multi-messenger approach is necessary. In particular, it is important to compare the single point sources available in the current gamma-ray catalogues with the IceCube data, considering their spatial, timing and energy distribution. After identifying specific plausible candidates for the IceCube events, it is possible to consider the sensitivity of gamma-ray experiments, like the High-Altitude Water Cherenkov Observatory and the planned Cherenkov Telescope Array Project, to verify the origin of the IceCube events. For the final correct identification of the IceCube neutrinos, the detection of the events from different experiments will be fundamental. In this regard, the estimation of the prospects for ANTARES, for the possible extension of IceCube and for the planned cubic kilometre neutrino telescope in the Northern Hemisphere, KM3NeT, is mandatory.

Keywords: high energy neutrinos,gamma rays,cosmic rays
Twinning Open Data Operational (TODO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Croatia,Croatia,Netherlands
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 799988.75
EU funding (EUR): 799988.75
Participants: 8
Project status: CLOSED

The project "Twinning Open Data Operational" (TODO) aims to leverage the interdisciplinary scientific excellence and innovation capacity of the University of Zagreb (UNIZG) in the field of open data to boost the supply and use of open government data in Croatia and beyond. Open data initiatives have resulted in greater availability of data, thereby realising ambitions such as improved efficiency and effectiveness of public services, increased transparency, accountability and citizen participation, and economic and social value creation. Open data research is a crucial component in creating and accelerating sustainable and innovative open data ecosystems. However, open data and open data research in Croatia are still in its infancy. With the support of key organizations in the Croatian open data ecosystem and esteemed national and international experts, TODO will enhance the research capacity and research excellence in open data research of UNIZG and its staff through the partnership with two leading universities in the open data domain, University of the Aegean (UAEGEAN) and Delft University of Technology (TUDELFT). TODO will develop and implement an interdisciplinary multi-domain open data research approach to increase the maturity of the concept and impact of the open data ecosystem in Croatia and beyond. The activities directed at training, knowledge exchange, collaboration, outreach and long-term sustainability should establish an internationally leading open data research ecosystem at the UNIZG. Through research, TODO will explore the gaps between supply and demand of open data and build understanding of an open data ecosystem in Croatia. Participation in existing international networks, together with the newly built scientific excellence and innovation capacity and increased mobility of UNIZG staff, will stimulate success in attracting research and education funding and the establishment of a sustainable academic open data research ecosystem in the UNIZG.

Keywords: open data research,interdisciplinary research,multidomain research,scientific excellence,economic value,social value
Edge AI-deployed DIGItal Twins for PREDICTing disease progression and need for early intervention in infectious and cardiovascular diseases beyond COVID-19 (DIGIPREDICT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Cyprus,Switzerland,Switzerland,Belgium,Switzerland,Sweden,Netherlands,Netherlands
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 5978343.5
EU funding (EUR): 5978343.5
Participants: 10
Project status: SIGNED

The interplay between viral infection, host response, development of (hyper)inflammation and cardiovascular injury in COVID-19 is currently poorly understood which makes it difficult to predict which patients remain with mild symptoms only and which patients rapidly develop multi organ failure. The solution offered by DIGIPREDICT is an Edge Artificial Intelligence (AI) based, high-tech personalized computational and physical Digital Twin vehicle representing patient-specific (patho)physiology, with embedded disease progression prediction capability, focusing on COVID-19 and beyond. DIGIPREDICT proposes the first of its kind Digital Twin, designed, developed and calibrated on i) patient measurements of various Digital Biomarkers and their interaction, ii) Organ-On-Chips (OoCs) as physical counterpart using patient blood for personalized screening and iii) integration of those physiological readouts using AI at Edge technologies. The final goal is to identify and validate patient-specific dynamic digital fingerprints of complex disease state and prediction of the progression as a basis for assistive tools for medical doctors and patients. Using and improving state-of-the-art OoCs and Digital Biomarkers (for physiology and biomarkers in interstitial fluid) we will measure detailed response to viral infection. By closely monitoring the response with wearable multi-modal Edge AI patches, we aim to predict in near real-time the progression of the disease, support early clinical decision and to propose patient-specific therapy using existing drugs. We will combine scientific and technical excellence in a highly multi- and inter-disciplinary project, bringing together medical, biological, electronical, computer, signal processing and social science communities around Europe to setup Digital Twin at Edge. We will enable an Edge-to-Cloud vision, significantly advancing current state of the art and setting up a new European community for researching and applying Digital Twins.

Keywords: digital twin,edge ai,organs on chip,digital biomarkers,wearables,covid 19,coronavirus,ai aided clinical prediction,personalized medicine,interstitial fluid,hyperinflamation,drug repurposing
The reception of ancient Greece in pre-modern French literature and illustrations of manuscripts and printed books (1320-1550): how invented memories shaped the identity of European communities (AGRELITA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2499202.5
EU funding (EUR): 2499202.0
Participants: 2
Project status: SIGNED

Until now the reception history of ancient Greece in pre-modern Western Europe has focussed almost exclusively on the transmission of Greek texts. Yet well before the revival of Greek’s teaching, numerous vernacular works, often illustrated, contained elaborate representations of ancient Greece. AGRELITA will study a large corpus of French-language literary works (historical, fictional, poetic, didactic) produced from 1320 to the 1550s in France and Europe, before the first direct translations from Greek to French, as well as the images of their manuscripts and printed books. It thus aims to challenge one of the great narratives that still prevails in European history: that the revival of interest in ancient Greece only took place through the first direct contacts with Greek works. It will change our perception of the Renaissance. The study of these works and their illustrations (text and image’s dialogue and powers of each) will analyze the representations of ancient Greece from the unexplored perspective of the elaboration of a new memory. It will reveal its structure, its meanings, and the various uses that authors made of it with respect to national, regional or European communities they depicted in their works. It will allow to better understand how, at a time which inherited negative preconceptions about the Greeks, Europe nevertheless began to claim ancient Greece as one of its legacies; and lead to a reassessment of the role played by Greece in Western European identities shaping processes. This promises considerable advances in our understanding of the new representations of these communities in this period. AGRELITA also aims to contribute to a general reflexion on the formation of heritages and identities. Its results will provide new insights on our perception on the issue of identity building, at different levels, local, national and European. They will be able to irrigate the research on modern times in history, sociology, memory and European studies.

Keywords: literary studies,medieval and early modern french literature,ancient greece,classical reception studies,book history,text and image,cultural memory studies,national,regional and european identities
Validation of SimVis Technology (SimVisTec)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-12-31
Duration (months): 16.0
Total project cost (EUR): 77500.0
EU funding (EUR): 77500.0
Participants: 1
Project status: CLOSED

2Eyes Vision is a streamline and dynamic company, specialized in optics and visual corrections. At present, the main project of the company is the creation of a new product, called SimVis Gekko, a visual simulator device that allows the surgeon to take personalized decisions on the lens to be implanted based on the patient’s preference. 2Eyes Vision has scarce human resources to continue developing the SimVis technology due to several barriers: - Optical engineers are a rare breed. There are less than 10,000 optical engineers worldwide compare to an estimated 150,000 mechanical engineers and 250,000 electrical engineers. In Spain, in particular, where 2Eyes is based, Optical Engineering Programs does not exist, but is does in EU countries such as France and the Netherlands. The development of the Sim Vis technology requires high level skills and knowledge in optical engineering and it is difficult to find this talent in Spain. - 2Eyes Vision is a young company, with a great potential, but which may be not very attractive to a experienced PhD. The company needs an external support, such as the offered by the EU sponsorship, trough funding programs, in order to consolidate its position as a reliable company for the attraction of talent and foreign entrepreneurial human capital. - There is an unquestionable relationship between development of the product and incomes. 2Eyes Vision is having difficulties, due to the lack of human resources, to develop the SimVis Gekko and, therefore, the incomes have also been low. And this makes difficult the recruitment of new high qualified employees. This vicious circle can be broken by means of EU support, institutionally and financially. The main aim of the SimVisTec project is the recruitment of a highly qualified international PhD, who will be in charge of the development of the SimVis Technology. The company will establish with him/her a long-term contractual relationship, based on mutual training and sharing of experience

Keywords: intraocular lenses,visual simulator,presbyopia,talent recruitment,innovation potential