Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Probabilistic Non-Rigid Registration for Safe Brain Tumor Resection (SafeREG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Brain tumors strike people in the prime of life. Surgical resection is the initial treatment for nearly all brain tumors and aims at maximizing the extent of tumor resection while preserving the patient's cognitive function. To optimize this tradeoff, neuronavigation systems have been developed to provide intraoperative guidance to surgeons. These systems allow for the visualization of the position of surgeons' surgical tools relative to the tumor and critical brain areas visible in preoperative Magnetic Resonance Imaging. However, these systems become inaccurate as the surgery progresses since they do not account for brain deformation and tissue resection occurring during surgery. In an interdisciplinary effort, project SafeREG combines the researcher's background to the expertise of computational scientists from INRIA and clinicians from Parisian hospitals. Its objective is to invent a novel image registration methodology with intraoperative ultrasound that is rich enough to capture complex deformations occurring at the tumor and resection cavity boundaries, fast enough to be employable clinically, and interpretable enough for informed decision-making by neurosurgeons. This will be accomplished by pushing the envelope of scientific knowledge in (1) cross-modality domain adaptation for weakly- and unsupervised image segmentation; (2) modality-invariance representation learning using contrastive learning; (3) non-rigid registration with discrete probabilistic methods; (4) simulated-based variational inference for registration uncertainty quantification that leverages biomechanical knowledge. This research has the potential to deliver accurate and informed image-guided surgery, conferring a lower risk of new neurologic deficits and improved patient prognosis. Beyond neurosurgery, it has broad applications to additional areas of image-guided therapy, including spine, liver, and prostate surgery.

Keywords: surgery
Seeing in the New Light: Photoreceptor Expression System for Cyanobacteria (PhotoCyX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

Cyanobacteria, the green microbial factories, are able to produce important biochemicals such as biofuel and bioplastics that offer a timely solution to many of the environmental challenges of our time, such as pollution and fuel security. The stability of the process and production yield, however, are dependent on the optimum synthesis of the enzymes involved in their metabolic processes. The goal of this research is to create a cyanobacterial expression tool that responds to red light based on a phytochrome photoreceptor. This tool will enable precise and highly tunable control of cyanobacterial gene expression with two wavelengths of red light. While the study is expected to show the potential of photoswitches for controlling biological processes, it will likely disclose distinct obstacles in the search for an ideal cyanobacterial expression system. The project will start with the construction of expression plasmids and their application to the cyanobacterium Synechocystis sp. PCC 6803. The light responses of the resulting expression strains will then be tested by illumination experiments, where the increased expression of the reporter (green fluorescent protein) will be detected with fluorescence spectroscopy. The proposed 24-month project will take place at the University of Jyvaskyla (Finland) under the supervision of Dr. Heikki Takala. The project also includes a two-month secondment training session at the laboratory of Prof. Andreas Möglich at the University of Bayreuth (Germany). This project is designed to combine the skills of the researcher in cyanobacterial studies and the expertise of the supervisor in phytochrome biology. Overall, the planned activity is methodically structured to nurture new abilities while addressing knowledge gaps. The project will provide the applicant with academic excellence, leading to higher prospects for a tenured academic position in Europe.

Keywords: photoreceptor,cyanobacteria,phytochrome,gene expression
Nano-imprint lithography of titania-based metaoptics (METAPRINT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 3533214.29
EU funding (EUR): 2473250.0
Participants: 1
Project status: SIGNED

METAPRINT "Nano-imprint lithography of titania-based metaoptics" targets the nano-fabrication of near eye displays for augmented reality (AR) smart-glasses by direct printing hard ceramics (e.g. TiO2). It will deliver Photonic Metasurfaces capable of redirecting virtual images from a microdisplay to the eyes. SOLNIL’s patented technology leverages: 1) printable inks based on sol-gel chemistry delivering a superior TiO2 material having a record high refractive index (up to 2.7) and transparency to increase the field of view of the virtual images by 40% with respect to current offers; 2) a deposition process, spin- or dip-coating performed at room temperature and pressure (avoiding slow and costly ultra-high vacuum approaches currently used for TiO2, e.g. atomic layer deposition); 3) a direct printing method of the liquid inks to produce 3D patterns (avoiding toxic resists for lithography, lift-off steps, and etching steps). Thus, beyond the superior performances of our material, we provide a massive reduction of both CapEx (>50 times) and CoO (>4 times) with respect to the incumbent top-down lithographic methods. SOLNIL has freedom to operate in this field and is already servicing several leading actors in the AR market by providing the technology for near eye displays based on diffractive waveguides (currently the leading method). METAPRINT will go beyond this common approach adopting Photonic Metasurfaces to: 1) enhance the light management efficiency (extending the battery lifetime), 2) improve spatial resolution of the virtual images and 3) the colour brightness. METAPRINT will showcase the viability of our approach by building a pilot-production line of near eye displays over 200 mm flat wafers and on 100 mm curved ones in order to define their performances and reproducibility and to estimate the costs of the process. The commercial goal is to license this technology either to our existing customers or to new ones scouted through the action.

Keywords: ar vr,near eye displays,nano fabrication,sol gel inks
SPACETIME: Simulating Palaeoconnectivity and Evolutionary Trends Impacting the Marine Environment (SPACETIME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Japan
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-17
End date: 2028-11-16
Duration (months): 36.0
Total project cost (EUR): 389156.16
EU funding (EUR): 389156.16
Participants: 2
Project status: CLOSED

Population structure in marine ecosystems is set by historical gene flow, often driven by larval dispersal through ocean currents. While state-of-the-art larval dispersal models contribute to our understanding of contemporary gene flow and population dynamics, they are limited by their failure to incorporate past connectivity, reducing our ability to understand population structure and assess models against palaeoecological data. The interdisciplinary SPACETIME project will address these major knowledge gaps by (i) quantifying palaeoconnectivity among all major coral reef systems since the Last Glacial Maximum, and (ii) advancing predictive ecological and genetic models for coral reef taxa by incorporating palaeoconnectivity and assessing model performance against the geological archive. SPACETIME will achieve these objectives through an ensemble of coupled hydrodynamic and biophysical simulations under past environmental conditions over the past 26,000 years, hindcasting the effects of changing climate and bathymetry on the physical oceanographic environment at a scale relevant to larval dispersal. The resulting palaeoconnectivity data will then be integrated into dynamical metacommunity and genetic models, which will be used to investigate the role of palaeoconnectivity in deglacial reef dynamics and population structure. Through these diverse simulations, and a comprehensive assessment against past and present genetic, ecological & oceanographic data, SPACETIME will generate valuable connectivity data for ecologists and evolutionary biologists to aid hypothesis generation and testing. The project directly supports impacts 21, 27 & 28 of the Horizon Europe 2025-2027 Key Strategic Orientation by improving models guiding biodiversity conservation activities. Finally, the training programme will train me in population genetics, model-data integration, and project management & supervision, supporting my development as a leader in interdisciplinary marine science.

Keywords: oceanography,palaeoceanography,marine dispersal,connectivity,glacial,lgm,coral reef,cmip,pmip,historical ecology
European Social Innovation Advisory and Funders Network in support of EU Mission Objectives (SI-Mission-Facility)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Coordination and support actions
Countries involved: Austria,Germany,Netherlands,Slovenia,Greece,Romania,Sweden,Italy,United Kingdom,Portugal
Call: A European Social Innovation Advisory Network in support of EU Mission Objectives (HORIZON-MISS-2024-CROSS-01, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 2499522.5
EU funding (EUR): 2499522.5
Participants: 11
Project status: SIGNED

The overall objective of the project is to unlock the untapped potentials of social innovations (SIs) to boost the EU Missions by promoting, activating, scaling and mainstreaming SIs and by engaging and advising SI funders, investors, social innovators and R&I policymakers at European, national and local level through a series of interconnected measures. To attain this objective, we will address four Key Actions: 1. Identify an evidence base of successful and - regarding the EU Missions - auspicious SIs and co-create suitable impact pathways and anchor points for the integration of SIs in future calls and topics of the EU Missions. 2. Provide training and advice through our Training and Scaling Lab about the opportunities provided by the EU Missions, by upgrading the skills of social innovators and support organisations for successful scaling and participation in calls of the EU and of private and public funders dealing with mission related themes. 3. Create a SI Funding and Investors’ Network to advise and engage private and public funding authorities in supporting, financing and scaling powerful SIs for the EU Missions’ purposes and by expanding the range of financial instruments with the help of a SI Investment Lab. 4. Establish a Community of Practice (CoP) to implement regular exchange and learning between EU Missions, the SI Funders and Investors’ Network and social innovators to meet demand and supply and to co-create a Research Agenda to make the best use of SI for the EU Missions. The Key Exploitable Results (KERs) of the project are a Catalogue of SI impact pathways (KER-1); Operational Training and Scaling Lab (KER-2); 30 credible scaling plans (KER-3); a committed funding network to support EU Missions established (KER-4); one financial Framework Partnership Agreement for a networked catalytic fund prepared (KER-5); A co-designed research agenda (KER-6) and >200 organisations engage in exchange and dialogue (KER-6).

Keywords: social innovation,eu missions,investment,funding,scaling,social entrepreneurship
Spatial arrangement and interactions of HSV-1 cell entry associated proteins on the native viral envelope (HSV1ENTRYPROTEINMAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Herpesviruses are a family of large, complex, DNA viruses that are highly prevalent across the global human population, causing life-long infections and cycle between latent and active disease. The severity of diseases caused by this viral family ranges from cold sores, genital ulcers and blisters to blindness, meningitis, cancer, and congenital defects. Herpesviruses present a significant public health concern due to high prevalence, ease of transmission, severity of associated diseases, lack of vaccines for most species, and toxicity of available medical interventions. There remains a pressing requirement to develop novel antiviral drugs to prevent diseases associated with Herpesvirus infections. Entry of HSV-1, the focus of the proposed research, is dependent on membrane fusion mediated by virally encoded glycoproteins gB, gD, gH, and gL found on the viral envelope. Although all four glycoproteins are known to be necessary for membrane fusion, the molecular details and stoichiometry of the interactions as well as how the interactions regulate or influence the fusion process remains unknown. The proposed project aims to uncover the spatial arrangement and interactions of the HSV-1 cell entry proteins. I will employ a multidisciplinary approach combining methods and data from structural biology, biochemistry as well as biophysics to solve the mechanistic details of a virology question. The proposed research is highly innovative as it is designed to push current technological barriers by taking advantage of recent methodological advances to answer specific key biological questions in herpesvirus entry. I will determine at molecular resolution, the spatial arrangement and temporal interactions between essential entry proteins required at the onset of the HSV-1 infection. This project has the potential to unveil the detailed mechanism of action of viral glycoproteins in their native environment that ultimately lead to HSV-1 fusion.

Keywords: herpes simplex virus 1,viral entry,host pathogen interactions,electron cryotomography,sub volume averaging,correlative light and electron microscopy,fluorescence microscopy
Quantifying fault response to enhanced climate-driven erosion using cosmogenic nuclides and geomechanical models (CosMechNuclides)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Mountain topography embeds a signal of past climate-driven erosion and tectonic evolution. Numerical models are powerful tools to characterize this delicate interplay and outputs can be used as a framework to understand the current climate or forecast future fault behavior and earthquakes. To validate models of climate and tectonic interactions during mountain building requires high-resolution records of erosion rates, sedimentation rates, climate variability, and fault activity. However, sites with detailed Quaternary records of all these variables are rare, which hinders our ability to validate model outputs. A multi-system approach, using field data to calibrate models, is required to enhance the predictive power of models and their capacity to tackle major unresolved tectonic and climatic problems, like how climate-enhanced erosion affects rates of faulting. This project will: 1) develop cutting-edge, data-driven, geomechanical models that integrate tectonics, climate, and erosion during mountain building; 2) collect new field data (10Be boulder ages and high-resolution topographic data) to generate a high-resolution record of Quaternary fault activity in the Andean foreland and supplement this data with existing erosion rates, rock exhumation rates, and sedimentation records; and 3) calibrate and apply the models using the field data to quantify the extent that climate-driven erosion affects rates of tectonic processes. This project will push the boundaries of our understanding of how tectonic and climatic variables influence landscape evolution whilst developing data-driven geomechanical modelling techniques with powerful applications to widespread tectonic, climatic, and sedimentological processes. The project will also give the researcher experience in a pioneering modelling field, whilst fostering intra-European and global collaborations and helping the researcher achieve their career goal of becoming an independent academic in Europe.

Keywords: active tectonics,climate and tectonics,landscape evolution modelling,geodynamic modelling,cosmogenic nuclides,topographic analysis,fault scarps,geomorphology
Pushing forward the market potential and business models of waste heat valorisation by full-scale demonstration of next-gen heat upgrade technologies in various industrial contexts. (PUSH2HEAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Germany,Italy,Switzerland,Belgium
Call: Full-scale demonstration of heat upgrade technologies with supply temperature in the range 90 - 160°C (HORIZON-CL5-2021-D4-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 9739703.38
EU funding (EUR): 7840312.9
Participants: 20
Project status: SIGNED

As part of the EU strategic agenda to build a climate-neutral and green Europe, increasing energy efficiency of industry is among the priorities of the Green Deal. Process heat has a significant weight in the total energy demand of the European industry and increased energy efficiency of industry through the recovery and upgrade of waste heat is one of the first steps towards decarbonization in the industrial sector. Although different heat upgrade technologies exist, their wide deployment is not taking place due to different technical and non-technical barriers hindering the uptake. PUSH2HEAT will aim to overcome these implementation barriers and push forward the market potential and business models of heat upgrade technologies by real full scale demonstration of different heat upgrade systems in relevant industrial sectors with high waste heat recovery and upgrading potential, with supply temperature in the range 90-160ºC. Different heat upgrade technologies will be scaled-up to optimize their efficiency and economic performance and demonstrated in selected industrial demo-sites covering a representative sample of the most relevant industrial processes with heat recovery potential. Economic and country specific regulatory barriers, summed up to the technical ones, greatly influence the deployment of the heat upgrade technologies. To tackle this, PUSH2HEAT intends to demonstrate suitable busines models and dedicated exploitation roadmaps for a higher penetration of heat upgrade systems aiming to contribute to meet the industry decarbonization targets. For achieving its ambitions, PUSH2HEAT consortium gathers different heat upgrade technology manufacturers, industrial end-users where demonstrations will take place, engineering and business oriented companies as well as expert RTD partners in the field, together with the European association representing the heat upgrade technologies stakeholders.

Keywords: heat pumps,heat transformers,heat upgrade,heat valorisation,waste heat,energy efficiency,industrial demonstration,business models,impact assessment