Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AUTHENT-NET – Food Authenticity Research Network (AUTHENT-NET)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Italy,Italy,Iceland,Spain,Norway,Belgium,France,France,Czechia,Netherlands,United States,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Authentication of food products (H2020-SFS-2015-1, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 521831.25
EU funding (EUR): 499533.75
Participants: 19
Project status: CLOSED

It is acknowledged that historically anti-food fraud capability within Europe has not been consolidated and lacks the coordination and support structures available to those working in food safety. There are various initiatives underway to redress this balance e.g. DGSanté’s Food Fraud network, DG Research’s FoodIntegrity project, as well as numerous national programmes and industry initiatives. One pivotal area that still needs to be addressed is bringing together national research funding bodies to facilitate the development of transnational research programmes. AUTHENT-NET will address this need by mobilising and coordinating relevant research budget holders in order to facilitate the eventual development of a transnational European funding vehicle that will allow Members States (MS) to jointly fund anti-fraud research. Authent-Net comprises a core group of 19 participants from 10 MS, 1 NGO and the US, who are either National research funding bodies; experts in food authenticity, and/or experts in transnational funding mechanisms. AUTHENT-NET will: 1) Bring together relevant MS R&D budget holders to coordinate inter-disciplinary research effort and build a cohesive and sustainable network 2) Undertake stocktaking of existing national research and assess against the international landscape 3) Establish transnational mechanisms and instruments for collating and exchanging information on food authenticity research 4) Develop a high level research and innovation strategy for transnational research and a rationale for a potential ERANET on food authenticity The two year project will have the following expected impacts: improved coordination and communication between relevant MS research budget holders; enhanced cognisance of existing national research; joint strategy for food fraud R&D; agreed priorities and capability to deliver transnational European research on food fraud.

Keywords: food authenticity,research,member states,mapping,networks,national funding bodies,transnational,standard,food fraud,research and development,food integrity,food safety,data collection
Identification and validation of human proteins that control tau seeding in cell-based and in vivo models (Tau Seeding)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The microtubule-associated protein tau is the most commonly misfolded protein in neurodegenerative disorders including Alzheimer’s disease and other related tauopathies. These neurological illnesses are hypothesized to share a common mechanism of disease progression, where pathogenic aggregates or ‘seeds’ of the tau protein function as templates promoting misfolding of functional, soluble tau protein. Under this premise, therapeutic strategies that modulate the seeding cascade, have high potential to interfere with the disease process. I will apply a recently developed highly sensitive and specific FRET-based biosensor cell assay as well as C.elegans to identify proteins that robustly influence tau seeding to understand the self-propagation process, ultimately aiming to stall disease progression. To this purpose, I will perform an shRNA-based knockdown screen of ~500 target genes preselected from literature, with potential to influence tau seeding. These will include known interactors of tau, proteostasis and tau life cycle regulators, and kinases, which modify tau post-translationally. After systematic validation, hits will be comprehensively investigated to unravel the mechanistic details of how modulation of the seeding activity was induced by the relevant gene. In addition, based on the results from the cellular assay, network models will be generated that delineate the causal relationships between identified target genes and tau seeding. This will help to understand, which proteins are able to directly or indirectly affect tau seeding, based on which new drug screens can be established. Moreover, already known drug targets will be attempted to be linked to cellular pathways, which have been identified to be relevant to tau seeding. In the medium term, this study may not only identify novel target genes and molecular pathways but also lay the important foundation to identify chemical compounds that slow or inhibit tau seeding.

Keywords: tau seeding assay,hek293t biosensor cell line,shrna and crispr,cas 9 mediated genome modification,proteostasis network,chaperones,kinases,c elegans,fret flow cytometry
Social Platform on Cultural Heritage and European Identities (CULTURALBASE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Italy,Spain,Hungary,France,United Kingdom,United Kingdom
Call: Social Platform on Reflective Societies (H2020-REFLECTIVE-SOCIETY-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 1039266.24
EU funding (EUR): 998646.0
Participants: 7
Project status: CLOSED

Through a comprehensive perspective that includes the most relevant social and political connections, the project aims to address the proposed topic from a double standpoint, namely, an analytical as well as a public policy perspective. We start from the idea that since the second half of the last century culture has experienced a profound mutation, through which its position and role in the social dynamics have been transformed. Whereas it was previously confined to a purely superstructural position, it now constitutes an essential basis of today’s society. In the context of cultural digitization and globalization the entire cultural ecosystem has changed, which has radically altered - and at the same time, intensified - the relationship between cultural identity, cultural heritage and cultural expression. This transformation has occurred both at the level of the professional cultural sector as well as in society as a whole. The new challenges and the new potential of culture, where these three pillars - cultural identity, cultural heritage and cultural expression - intertwine, will be considered in the work of the platform along three axes: 1. Cultural memory 2. Cultural inclusion 3. Cultural creativity These are designed to research debates relating to heritage in the institutions and practices of cultural memory; how the focus on diversity and inclusion impacts on the practices of memory institutions, including on stakeholders and networks; what this reconfiguration contributes to new or post-national oriented narratives about identity and European values; and how heritage, cultural diversity and creativity relate in the context of huge cultural transformations such as the ones represented by digitization and cultural globalization.

Keywords: cultural heritage,social identities,minority groups,cultural creativity,european history,cultural memory,cultural policy,art worlds,cultural sector
Knowledge-Based Information Agent with Social Competence and Human Interaction Capabilities (KRISTINA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Greece,France,Netherlands
Call: Multimodal and Natural computer interaction (H2020-ICT-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 3633801.25
EU funding (EUR): 3633801.0
Participants: 9
Project status: CLOSED

In Europe, migration is tradition – and not only since the European legislation changed towards free migration of European citizens. This is not free of challenges. Especially in the case of care, migrants, often face a double challenge: (i) not to speak the language and not to be acquainted with the culture of the resident country, and (ii) be unfamiliar with the care and health administrations of the country. As a consequence, e.g., elderly migrants in care homes suffer from social exclusion, with their relatives also struggling with getting the right information and interacting with the administration, migrants at home are often reluctant to go to see the doctor in case of health issues, a tendency that is often further aggravated by cultural matters. Migrant temporary care workers, who in addition often do not have an adequate professional training, face the problem of isolation, lack of professional background information and deficient communication with both the cared and the supervision personnel. KRISTINA’s overall objective is to research and develop technologies for a human-like socially competent and communicative agent that is run on mobile communication devices and that serves for migrants with language and cultural barriers in the host country as a trusted information provision party and mediator in questions related to basic care and healthcare. To develop such an agent, KRISTINA will advance the state of the art in dialogue management, multimodal (vocal, facial and gestural) communication analysis and multimodal communication. The technologies will be validated in two use cases, in which prolonged trials will be carried out for each prototype that marks the termination of a SW development cycle, with a representative number of migrants recruited as users from the migration circles identified as especially in need: elderly Turkish migrants and their relatives and short term Polish care giving personnel in Germany and North African migrants in Spain.

Keywords: multilingual intelligent embodied agent,social competence,adaptive dialogue,expressive speech recognition and synthesis,discourse generation,vocal,facial and gestural social and emotional cues
Network of Science with and for Society National Contact Points (SiS.net2)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Egypt,Israel,Germany,Spain,Italy,Iceland,Cyprus,Belgium,Croatia,Sweden,Greece,Poland,France,Czechia,Portugal,Portugal
Call: Science with and for Society National Contact Points (NCPs) in H2020 (H2020-GARRI-NCP-2014-1, 2014)
Start date: 2014-11-01
End date: 2018-12-31
Duration (months): 50.0
Total project cost (EUR): 1999593.75
EU funding (EUR): 1999593.75
Participants: 18
Project status: CLOSED

Science with and for Society has a vital role to play in bringing together a wide range of stakeholders in order to build capacities and develop innovative ways to connect science to society through Responsible Research and Innovation measures. This demands that the Science with and for Society National Contact Points (NCPs) are able to orientate in the wide area of policy behind the programme, its topics and research areas as well as in Horizon 2020 rules and regulations and in addition, they need to have extensive knowledge of the different groups of stakeholders, in order to be able to fulfil their job. The proposal focuses on identifying and sharing good practices and raising the standard of proposals by organising joint activities of NCPs. The consortium ensures a balance of experienced NCPs and newcomers in order to build on knowledge and enhance skills and competences of all NCPs within the programme. This will result in more consistent and improved NCP services which will enhance participation in Science with and for Society calls.

Keywords: horizon 2020,science with and for society,national contact points,responsible research and innovation,ethics,open access,gender,governance,education,communication,innovation
Photoswitching molecules for the spatiotemporal control of cancer stem cells with light (PhotoStem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-11-15
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

PhotoStem aims to develop a cutting-edge approach to overcome the main cause of patient relapse in cancer treatment. Cancer stem cells (CSCs) are a small population of cells within a tumour characterised by their ability to self-renew and to induce tumourigenesis. Current chemotherapy acts only on the bulk of the tumour mass, leaving CSCs unaffected; this is thought to be the main cause of resistance to cancer treatment. Despite growing knowledge on the existence of CSCs, similarities to normal stem cells challenges the design of selective inhibitors and modulators. Relapse to cancer treatment is an enormous challenge and there is an urge to identify novel therapeutic approaches to target CSCs. Photopharmacology is an emerging field that seeks to precisely control the activity of bioactive molecules with light, allowing for activation or repression of biological function at a specific space and time. It constitutes a truly disruptive innovation that can represent a new direction in drug therapy. We herein propose to use novel photoactivable molecules to target CSCs with precise spatiotemporal control using light. Initially, we will develop novel photoswitchable versions of known inhibitors, and will study their effect in leukemia stem cells both in vitro and in zebrafish models. We will then expand our learnings to target CSCs of solid tumours. The achievement of such an ambitious objective will only be possible via a network of multidisciplinary researchers. The researcher will combine her expertise in drug discovery and leukemia with state-of-the-art photopharmacology techniques from leaders in the field at the host institution. Training-through-research at the partner organisations that include well-recognised experts in haematological malignancies, myeloid zebrafish models and CSC xenograft models will enable the expansion to in vivo applications. The proposed work will provide both new directions in targeted cancer therapy and powerful tools for cell biology.

Keywords: photopharmacology,cancer stem cells
Screening of small molecules to fight SARS-CoV-2 by combining novel approaches and sustainability (SPOTLESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 257209.92
EU funding (EUR): 257209.92
Participants: 1
Project status: SIGNED

The novel SARS-CoV-2 is a lethal human pathogen with no FDA approved vaccines or drugs. An important step of the virus life-cycle is the viral glycoprotein S activation by Proprotein Convertases (PCs) which are proteases with a broad spectrum of cellular substrates. Inhibition of the processing step locks the virus into a form which eventually is no more pathogenic. Therefore, PCs represent attractive drug targets to fight against SARS-CoV-2. To date, there are no PCs inhibitors available for the in vivo use. Here, I propose three approaches to look for small molecule inhibitors of PCs, exploiting the virus cleavage site. Beside the classical in vitro screening, I aim to exploit novel PCs sensor platforms based on innovative ideas to ameliorate and simplify the readout. One attempt will see the use of luciferase reporters on the blueprint of sensors that I have recently published; following a second method, I will take advantage of the cellular death machinery as an on/off cleavage signal. In turn, these virtuous assays will contribute to a sustainable research approach. Novel PCs inhibitors are of great value against Covid-19 infections. Importantly, the inhibitors can be re-purposed against novel emerging pathogens, if necessary. Indeed, PCs dependence is becoming a distinctive mark of severe pathogenicity.

Keywords: sars cov 2,covid 19,proprotein convertases,screening,inhibitors,cleavage
Widening EU-CELAC policy and research cooperation in Personalised Medicine (EULAC-PerMed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Italy,Israel,Argentina,Uruguay,Germany,Spain,France,Chile,Panama,Brazil
Call: Actions in support of the International Consortium for Personalised Medicine (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 2065618.75
EU funding (EUR): 1999993.75
Participants: 15
Project status: CLOSED

In order to strengthen the global efforts on Personalized Medicine (PerMed) and the cooperation of the EU-CELAC countries to them, a unique Bi-regional consortium of governmental and funding organisations is shaped with the support of leading stakeholders as associated partners. This project has the ambition to engage CELAC countries in the International Consortium on Personalized Medicine (ICPerMed) and in the ERANet ERAPerMed with the aim at advancing in the implementation of the Action Plan of ICPerMed based in the Strategic Research and Innovation Agenda, drafted by PerMed2020. Research on PerMed is a top priority for the EU as a strategy aimed at delivering personalised health and care solutions to benefit citizens. Results of R&I actions will generate and translate knowledge on disease aetiology and technological innovation into personalised health and care solutions. Areas of application include chronic, rare and communicable diseases. Research under this priority will also attempt to develop an outstanding economic impact due to the potential of PerMed to transform health systems. The collaboration of diverse actors from different world regions, disciplines and health-care systems are needed to implement in a holistic way new feasible and cost-effective PerMed approaches. Involvement in ICPerMed of RFOs and policy-making bodies from EU and from other regions, is the best way to push forward the impact of new findings and knowledge in the area. This CSA will be the vehicle for: i) Mapping existing programmes, capacities and expertise and gaps in CELAC countries; ii) Facilitating the incorporation of CELAC countries in ICPerMed and in the ERAPerMed; iii) Fostering the participation of CELAC countries in research mobility and transnational projects on PerMed, and a platform for EU‐CELAC collaboration on clinical trials PerMed focused; iv) Cross-border learning from R&I and ELSA for implementing innovations between research capacities based in EU and CELAC.

Keywords: personalized medicine,international,celac,health research programming,research funding orgaizations,omics,prevention,healthcare
A NOVEL RECONFIGURABLE BY DESIGN HIGHLY DISTRIBUTED APPLICATIONS DEVELOPMENT PARADIGM OVER PROGRAMMABLE INFRASTRUCTURE (ARCADIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Ireland,Cyprus,Slovenia,Norway,Greece,Greece
Call: Tools and Methods for Software Development (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3543864.0
EU funding (EUR): 3543864.0
Participants: 9
Project status: CLOSED

Given the inability of Highly-Distributed-Application-Developers to foresee the changes as well as the heterogeneity on the underlying infrastructure, it is considerable crucial the design and development of novel software paradigms that facilitate application developers to take advantage of the emerging programmability of the underlying infrastructure and therefore develop Reconfigurable-by-Design applications. In parallel, it is crucial to design solutions that are scalable, support high performance, are resilient-to-failure and take into account the conditions of their runtime environment. Towards this direction, the ARCADIA project aims to design and validate a Novel Reconfigurable-By-Design Highly Distributed Applications Development Paradigm over Programmable Infrastructure. The proposed framework will rely on the development of an extensible Context Model which will be used by developers directly at the source-code level. Proper Context-Model will be assisted and validated by IDE-plugins (for many IDEs) in order to re-assure that the generated executable files contain meaningful semantics. According to ARCADIA’s vision, the generated executables should be on-boarded by a Smart Controller which will undertake the tasks of translating annotations to optimal infrastructural configuration. Such a controller will enforce an optimal configuration to the registered programmable resources and will pro-actively adjust the configuration plan based on the Infrastructural State and the Application State. The Context-Model and the aforementioned ARCADIA toolset will be complemented by a Development Methodology that will assure that developed Highly Distributed Applications are Reconfigurable-By-Design. The framework is planned to be validated and evaluated on three use cases that will be deployed over testbeds that host heterogeneous programmable infrastructure.

Keywords: software development paradigm,programmable infrastructure,reconfigurable by design,model driven reconfiguration