Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
iRhom2 in neuroinflammation and pathogenesis of Alzheimer’s Disease (iRhom2 in AD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, a syndrome characterized by loss of memory and cognitive decline. AD has a dramatic socio-economical impact that is foreseen to worsen in the near future unless a cure is found. The pathology is triggered by the accumulation of Aβ oligomers that begins a cascade culminating with the formation of neurofibrillary tangles within the neuron and cell death. Neuroinflammation is emerging to play a key role in this process and it has been associated with the progression of the disease. The rhomboid-like protein iRhom2 has been recently identified as a genetic risk factor for AD, even though the underlying mechanism remains to be characterized. iRhom2 recently emerged as a novel pro-inflammatory protein required to traffic TACE (tumor necrosis factor-α converting enzyme) towards the plasma membrane and guide its maturation, thereby regulating the release of TNFα, a cytokine implicated in several inflammatory diseases. Consequently, iRhom2-/- mice are protected from sepsis and rheumatoid arthritis, which involve TNFα-dependent inflammation. In addition, the concept is emerging that iRhom2 may regulate trafficking of additional clients other than TACE, thus controlling other signalling events in neuroinflammation. The main objective of this proposal is to characterize the role of iRhom2 in neuroinflammation and in the progression of AD. I plan to cross an AD mouse model with iRhom2-/- mice and evaluate role of iRhom2 in the progression of the disease. In addition, I will use avant-garde proteomic approaches to identify novel iRhom2 clients in primary macrophages. Candidates relevant in neuroinflammation and AD will be further validated using an array of biochemical and functional assays. From this research I aim to identify new targets to develop therapies for treatment of AD, in line with the objectives of H2020 Work Programme to promote healthy ageing of the EU citizens.

Keywords: neurodegeneration,neuroinflammation,secretome,endoplasmic reticulum trafficking
Homotopy theory of spaces of homomorphisms (HOTHSPOH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

In this project we propose to study homotopy theoretic properties of spaces of commuting elements in compact Lie groups. These spaces play an essential role in mathematical physics and geometry, but only in the last decade a systematic study by homotopy theoretic methods has been initiated. Important open questions in the field concern the homology as well as the (stable) homotopy type. In the first part of the project, we attempt to prove a conjectural stable splitting theorem, which would establish an intriguing relationship between spaces of commuting elements and commuting varieties in Lie algebras, an object of classical interest in algebraic geometry. In the second part, we propose to investigate the phenomenon of homology stability for spaces of commuting elements in the unitary and orthogonal groups. Building on recent work of the experienced researcher, an approach to calculate the stable homology is presented. This is expected to uncover a wealth of previously unknown homology groups of these interesting spaces. The research conducted to achieve the project goals, together with the training in teaching and management received during the fellowship, will have a major positive impact on the career development of the experienced researcher. On the research level, this impact is through the acquisition of knowledge in new research areas, in particular in homology stability and the homotopy theory of Lie group actions. The project will be carried out in an exceptionally active and successful scientific community at the University of Copenhagen, supervised by a world expert in the homotopy theory of Lie groups. Completion of the project will serve as a springboard to build new collaborations and to enter further advanced projects in a range of areas. It is thus a perfect preparation for a high-level research career in mathematics.

Keywords: homotopy theory,homology,lie groups,homology stability,representations,stable homotopy theory,equivariant homotopy theory
Unlocking the potential of EU cultivated quinoa through the production of protein-rich quinoa flour and functional quinoa starch (QUINNOVA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The European Union is seeking solutions for reducing its dependency on protein imports, while consumers shift from animal to plant-based proteins. As an example, the global plant protein ingredients market is expected to reach more than €11bn by 2025. Currently 98% of the protein in this market comes from soy and wheat. Soy is mainly imported from non-EU countries (where GMO crops are authorised) and its intensive cultivation causes severe environmental issues e.g. deforestation and land-use changes. On the other hand, wheat protein needs to find a gluten-free replacer. Thus, EU food manufacturers are searching for alternative plant-based sources for their protein-fortified food products, which leads to an urgent need to scale-up the production of plant-based protein from alternative sources. Quinoa is recognised as an excellent crop with an outstanding protein quality and an amino acid score of 100% for adults. Its production in the EU has significantly grown in the last decade. However, commercial exploitation of quinoa-protein and its co-ingredients is not carried out because of the lack of breakthrough fractionation technology adapted to the special nature of quinoa seeds. We are GreenFood50, a Dutch company devoted to the production and commercialisation of quinoa-derived ingredients. We have developed QUINNOVA, an innovative dry fractionation technology that allows to unlock the full potential of quinoa. QUINNOVA food ingredients are in line with consumer demands and their functional properties are ideal for being used in tasty bakery, health, sports, vegetarian/vegan and gluten free applications. The process is environmentally friendly, with a reduced energy and water demand compared to alternative technologies. Our goal is to scale-up QUINNOVA to industrial level, contributing to cover the EU demand for high-quality plant-based protein. This will represent a quantum leap for GreenFood50, which will make food systems healthier and more sustainable.

Keywords: quinoa,vegetal protein,sustainable protein,fractionation,gluten free,starch,food ingredients,infant nutrition,sports nutrition,health nutrition,plant based,gluten replacement,amino acids
Predicting the Evolution of Antibiotic Resistance in Streptococcus pneumoniae (PEARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Streptococcus pneumoniae (the pneumococcus) is a bacterial species generally commensal to humans, but which occasionally causes infections responsible for the death of 800, 000 infants each year worldwide. Multiple genotypes exhibiting resistance to antibiotics have emerged in past years. Intriguingly, despite extensive antibiotic consumption operating strong selection for resistance, the latter remains at a stable frequency, 15% on average over the last 20 years in Europe. This is paradoxical, as robust coexistence of resistant and sensitive strains is unexpected under the simplest epidemiological models. In this project, I will investigate the possibility that coexistence is instead maintained by a more complex mechanism, relying on local adaptation to several niches characterized by different rates of antibiotic administration. I will develop a series of novel models with increasing realism and relevance to the context of S. pneumoniae, drawing from the often separate fields of population genetics and epidemiology. Starting with simple but general two- and multiple-niches models that allow for analytical solutions to provide initial insights, I will then build a more complex simulation model parameterized with biologically realistic contact and treatment structures. Output of this model will be confronted to large-scale patterns of spatial variation in resistance observed in epidemiological datasets. The analysis of these models will help us understand what factors facilitate the maintenance of coexistence in S. pneumoniae. This work may lead to better treatment policies to manage antibiotic resistance in this major pathogen.

Keywords: streptococcus pneumoniae,antibiotics,heterogeneous environment,local adaptation,age structure
Building a research infrastructure and synergies for highest scientific impact on ESS (BrightnESS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Sweden,Sweden,Switzerland,Switzerland,Hungary,France,France,Czechia,Netherlands,Denmark,Denmark,United Kingdom
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 19941964.0
EU funding (EUR): 19941964.0
Participants: 20
Project status: CLOSED

The science of materials has always been at the centre of scientific and technological progress in human development. The tools to understand materials that fashion them to meet our societal needs have been just as important. Thermal neutrons are one of the most powerful probes that look directly at the structure and dynamics of materials from the macro- to the microscopic scale and from nano-seconds to seconds. It is therefore natural that a group of 17 European Partner Countries have joined together to construct the world’s most powerful neutron source, the European Spallation Source (ESS). The importance of ESS has been recognised by ESFRI who have prioritised it as one of three Research Infrastructures (RIs) for this INFRADEV-3 call. However, simply constructing the most powerful spallation neutron source will not, by itself, ensure the maximum scientific or technological impact. What is needed is an integrated program that ensures that key challenges are met in order to build an ESS that can deliver high impact scientific and technological knowledge. With a timeline of 36 months, involving 18 Consortium Partners and a budget of € 19.941.964, the BrightnESS proposal will ensure that (A) the extensive knowledge and skills of European companies, and institutes, are best deployed in the form of In-Kind Contributions to ESS for its construction and operation, (B) that technology transfer both to, and from, the ESS to European institutions and companies is optimised and, (C) that the maximum technical performance is obtained from the ESS target, moderators and detectors in order to deliver world class science and insights for materials technology and innovation.

Keywords: ikc coordination,innovation,eric,key neutronic technologies,detectors,helium 3 crisis,moderators,realtime data management,enlargement of membership
3D Printing of Novel 2D Nanomaterials: Adding Advanced 2D Functionalities to Revolutionary Tailored 3D Manufacturing (3D2DPrint)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2023-03-31
Duration (months): 78.0
Total project cost (EUR): 2499942.0
EU funding (EUR): 2499942.0
Participants: 1
Project status: CLOSED

My vision is to establish, within the framework of an ERC CoG, a multidisciplinary group which will work in concert towards pioneering the integration of novel 2-Dimensional nanomaterials with novel additive fabrication techniques to develop a unique class of energy storage devices. Batteries and supercapacitors are two very complementary types of energy storage devices. Batteries store much higher energy densities; supercapacitors, on the other hand, hold one tenth of the electricity per unit of volume or weight as compared to batteries but can achieve much higher power densities. Technology is currently striving to improve the power density of batteries and the energy density of supercapacitors. To do so it is imperative to develop new materials, chemistries and manufacturing strategies. 3D2DPrint aims to develop micro-energy devices (both supercapacitors and batteries), technologies particularly relevant in the context of the emergent industry of micro-electro-mechanical systems and constantly downsized electronics. We plan to use novel two-dimensional (2D) nanomaterials obtained by liquid-phase exfoliation. This method offers a new, economic and easy way to prepare ink of a variety of 2D systems, allowing to produce wide device performance window through elegant and simple constituent control at the point of fabrication. 3D2DPrint will use our expertise and know-how to allow development of advanced AM methods to integrate dissimilar nanomaterial blends and/or “hybrids” into fully embedded 3D printed energy storage devices, with the ultimate objective to realise a range of products that contain the above described nanomaterials subcomponent devices, electrical connections and traditional micro-fabricated subcomponents (if needed) ideally using a single tool.

Keywords: additive manufacturing,3d printing,nanomaterials,2 dimensional nanosheets,supercapacitors,batteries,hybrids
SHARING A GENOME: CASTE ANTAGONISM AND COADAPTATION IN SOCIAL INSECTS (CASTECON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2023-06-30
Duration (months): 78.0
Total project cost (EUR): 2424263.0
EU funding (EUR): 2424263.0
Participants: 2
Project status: SIGNED

Eusociality, in which workers sacrifice their own reproduction to rear the offspring of queens, is a major focus of interest in evolutionary biology. A key aim during recent decades has been to understand the conflicts of interest within eusocial groups. In contrast, however, little is known about the underlying genetic architecture. In this proposal, we will use a mixture of field experiments and transcriptomics to address novel questions about the evolutionary dynamics of queen-worker interactions. Borrowing concepts from the field of sexual conflict, we will investigate a new idea: that the productivity of social groups is limited because castes are constrained by inter-caste genetic correlations from simultaneously reaching their optimal (dimorphic) phenotypes. We will also quantify caste dimorphism across an environmental gradient, and investigate the plasticity of dimorphism using transplants and social manipulations. In addition, we will cross-foster individuals between nests to test for coadaptation between queens and workers. And we will test a long-standing hypothesis experimentally for the first time: that queens manipulate worker phenotype in their own interests. The proposed research will force us to look at eusociality in a completely new way. How caste dimorphism can evolve, the possibility that its evolution could be limited by genetic constraints, and the processes that could resolve those constraints, are topics that have hardly been considered. Recent research has strongly emphasized conflict between queens and workers, but the coadaptation of complementary phenotypes may be just as important. Our approach will be multidisciplinary: we will capitalize on state-of-the-art transcriptomic technology in combination with innovative field methods, and use study systems that allow exceptional sample sizes to be obtained in the wild, where natural selection operates. The overall result will be a new and exciting perspective on queen-worker coevolution.

Keywords: transcriptomic and quantitative genetic approach to conflict in social groups
The Demonstration of Waste Biomass to Synthetic Fuels and Green Hydrogen (TO-SYN-FUEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Innovation actions
Countries involved: Italy,Germany,Italy,Spain,Germany,Germany,Italy,Germany,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Demonstration of the most promising advanced biofuel pathways (H2020-LCE-2016-RES-IA, 2016)
Start date: 2017-05-01
End date: 2022-09-30
Duration (months): 65.0
Total project cost (EUR): 14196108.72
EU funding (EUR): 12250528.13
Participants: 13
Project status: CLOSED

TO-SYN-FUEL will demonstrate the conversion of organic waste biomass (Sewage Sludge) into biofuels. The project implements a new integrated process combining Thermo-Catalytic Reforming (TCR©), with hydrogen separation through pressure swing adsorption (PSA), and hydro deoxygenation (HDO), to produce a fully equivalent gasoline and diesel substitute (compliant with EN228 and EN590 European Standards) and green hydrogen for use in transport . The TO-SYN-FUEL project consortium has undoubtedly bought together the leading researchers, industrial technology providers and renewable energy experts from across Europe, in a combined, committed and dedicated research effort to deliver the overarching ambition. Building and extending from previous framework funding this project is designed to set the benchmark for future sustainable development and growth within Europe and will provide a real example to the rest of the world of how sustainable energy, economic, social and environmental needs can successfully be addressed. This project will be the platform for deployment of a subsequent commercial scale facility. This will be the first of its kind to be built anywhere in the world, processing organic industrial wastes directly into transportation grade biofuels fuels which will be a demonstration showcase for future sustainable investment and economic growth across Europe. This project will mark the first pre-commercial scale deployment of the technology processing up to 2100 tonnes per year of dried sewage sludge into 210,000 litres per year of liquid biofuels and up to 30,000 kg of green hydrogen. The scale up of 100 of such plants installed throughout Europe would be sufficient to convert up to 32 million tonnes per year of organic wastes into sustainable biofuels, contributing towards 35 million tonnes of GHG savings and diversion of organic wastes from landfill. This proposal is responding to the European Innovation Call LCE-19.

Keywords: organic waste,thermal conversion,fuel upgrading,hydro de oxygenation,green hydrogen
New Market: an exploration into the changing nature of business environments, informal barriers and emerging markets in the post-Soviet region (NEW MARKETS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Estonia,Uzbekistan,Ukraine,Ireland,Finland,Sweden,Belarus,Georgia,Latvia,France,Kazakhstan,Kyrgyzstan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1104000.0
EU funding (EUR): 1104000.0
Participants: 12
Project status: SIGNED

The past ten years have seen several changes in post-USSR business environments. From Kazakhstan to Belarus, and eventually Uzbekistan in 2016, a growing number of post-USSR republics have gradually begun economic reforms to allow foreign businesses to operate in their territory. These declared intentions, however, are sometimes contrasted by non-official, or informal, barriers into domestic and regional markets. Indeed, from rampant corruption to the necessity to get protection from local oligarchs, entering post-Soviet markets involves several risks. New Markets addresses the current limited existence of clear instructions that could enable new, and existing economic actors to gain an overview into the hidden risks associated with business activities in the post-Soviet region. Our research follows a three stage approach: First, we will conduct a review of policy measures adopted in the past 10 years (2008-2018) to liberalize the markets in our target countries. Our analysis will compare three countries that have fully opened to foreign investors already in the early 2000 – Estonia, Georgia and Kyrgyzstan - with three countries that have only recently shown a more cooperative attitude - Belarus, Kazakhstan, Uzbekistan. We will survey the major mechanisms, and policies, adopted in these six countries to evaluate how they have ended up affecting the business environment. Second, we will conduct an empirical evaluation of the measures adopted for improving the business climate in the target countries. This will be done through a national survey of core business actors in each country Third, building upon results of the second stage, we will map challenges and opportunities in the region comparing macro and micro perspectives and testing government-led decisions against their results.

Keywords: caucasus,central asia,eastern europe,post ussr,informality,barriers,new markets