Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Origin, fate and function of wheat genes noncollinear with the other cereal genomes (NONCOLLINEARGENES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-08-01
End date: 2013-07-31
Duration (months): 24.0
Total project cost (EUR): 186748.0
EU funding (EUR): 186748.0
Participants: 1
Project status: CLOSED

In the framework of studies of the organization and evolution of the bread wheat genome, the host team has developed a large project aiming to characterize its largest chromosome, 3B, at the molecular level. A physical map of this giant chromosome (about the size of the soybean genome) was established in 2008 (Paux et al., 2008). Recently, in a pilot study prior to the complete chromosome sequencing (3BSEQ project), the host group produced and analyzed precisely 18 Mb of contiguous sequences representing the first large sample sequences available for the hexaploid wheat genome. The results showed that about 50% of the genes and pseudogenes identified in wheat are not collinear with the other grass genomes raising several questions about their origin, fate and expression in the wheat genome. The objectives of this project are to select a number of non collinear genes in different structural contexts and (i) determine whether these genes originate from interchromosomal duplications of genes ancestrally present at distant loci, (ii) investigate the molecular mechanisms and evolutionary forces involved in the shuffling of the gene content, including transposable elements, and (iii) analyze their expression patterns relative to collinear genes through qRT-PCR experiments and analysis of RNA Seq data that will be produced in the 3BSEQ project on 15 different RNA samples. We will investigate the molecular evolution of their sequences in a hexaploid context where homoeologous and paralogous gene copies are maintained.

Keywords: crop genetics,wheat,bioinformatics,non collinear,genes,evolution,synteny,interchromosomal duplications,sequence
The dynamic between airlines and high-speed trains in Europe (DATE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 201392.8
EU funding (EUR): 201392.8
Participants: 1
Project status: CLOSED

At a time when the EU attempts to reduce transport negative impact on the environment, meeting demand for long distance travel becomes more and more problematic. To address this problem, EU and some national governments have opted for a revitalization of European railways and the development of new lines for high-speed trains (HSTs) with the hope that mode substitution (from air to rail) will allow to meet demand for long distance travel at a lower environmental cost. Yet there is little known about the interaction between HSTs and air services. Most of the scientific literature focuses either on air or on rail transport, but almost not on the relationships between both. Moreover, research up to now does not take into account the impact of air transport liberalization on the quantitative and geographical development of air services and on their increasing affordability, particularly with the boom of low-cost airlines. Yet, this dynamic is changing in terms of competition and complementarity between rail and air services. In this context, the aim of this research is to investigate the Dynamic between Airplanes and high-speed Train modes in Europe (DATE) in order to evaluate the potential for HST development to cut air transport flows and the conditions required to support it. By refusing the traditional premise according to which HSTs reduce air supply out of hand, four objectives are set. First, leading a critical analysis of the literature on the relationships between HSTs and air services, providing a new vision linking both modes. Second, analysing all European HSTs services to determine the extent to which HSTs were able to reduce the supply of air services from 1981 to 2010. Third, analysing the factors determining the extent to which HST services can reduce air transport services, accounting also for regulatory frameworks. And finally determining the policy and planning implications of the results for the future development of European air and HST networks.

Keywords: transport geography,transport policy,environment,air transport,rail transport,liberalisation,low-cost airlines
Crystallography-assisted synthesis of zeolites with tailored acid site distributions (CRYSTALZEO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-11-01
End date: 2013-10-31
Duration (months): 24.0
Total project cost (EUR): 178601.6
EU funding (EUR): 178601.6
Participants: 1
Project status: CLOSED

This research deals with a long-term objective in zeolite science: the control of acid site distribution by varying synthesis parameters. In most catalytic reactions, the performance of zeolite-based catalysts depends on the distribution of the acid sites at the nanoscale level. The aluminium atoms in the zeolite framework structure are responsible for the formation of the acid sites, so if their distribution can be tailored so can that of the acid sites. In spite of intense interest, no method for controlling the distribution of acid sites has yet been developed. The synthesis strategy I developed during my PhD research has allowed, for the first time, the distribution of acid sites in the zeolite ferrierite to be modified as a function of the organic structure directing agents (SDAs) employed in its synthesis. With the aim of converting this synthesis strategy into a general methodology applicable to any zeolite, an in-depth understanding of the interactions that are established between the organic SDA molecules and the oxygen atoms of the framework is required. This will allow the SDAs appropriate for the control of aluminium distribution in other zeolites to be chosen rationally. Crystallography is a powerful technique for this purpose, as it can provide detailed information about the location of the organic SDAs within the pores of the zeolite, as well as about the location of the framework silicon and oxygen atoms. This innovative use of crystallography, not just to study the zeolites obtained, but also as a tool to facilitate the design of optimal synthesis conditions for other zeolites, ensures that these syntheses will not be carried out in a trial and error basis. The candidate will perform crystallographic studies at the ETH Zürich (host institution), and this training will be a key to the development of her scientific career, as the expertise in structural characterisation of zeolites will be a perfect complement to her solid synthesis background.

Keywords: technological sciences: zeolites,crystallography,rietveld,structure,tailored,aluminium,acid sites distribution,catalysis,structure directing agents
Mass Career Customization -a flexible career approach : effects on women's career advancement and wellbeing. (GENDERMASSCAREER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 169485.6
EU funding (EUR): 169485.6
Participants: 2
Project status: CLOSED

During my IEF I will investigate on the effects of a new innovative career tool on the career advancement of women inside a multinational Accountancy firm. The overall objective is to examine how organisations by the use of more flexible career models can create inclusive organisational cultures that promote equal treatment and health and well-being among their female workforce. In this regard, I follow an important request of the EU – the promotion of gender equality and employability. To address this question I will apply an interdisciplinary approach using theories and methods from the field of organisational behaviour, applied psychology, sociology and management. Data originates from an existing dataset (n= 1043) that will be complemented by (1) a follow up employee survey and (2) a survey directed to employees’ supervisor. Data is obtained in two points of time in order to observe changes in objective and subjective careers success and other individual outcomes such as wellbeing, job satisfaction, career satisfaction, work-family conflict, stress, turnover intentions. Furthermore, objective data on career advancement of women in comparison to men will be derived from company data (e.g. entry assessments, performance ratings, promotions, salary level data, and turnover rates). The project will be carried out in cooperation with an industry-academic partnership between the Amsterdam Center for Career Research (ACCR), VU (Vrije Universiteit) Amsterdam and a multinational Accountancy firm in the Netherlands.

Keywords: human resource management,organisational behaviour,management,gender,careers
Deciphering the functions of Sox6 and myosin-encoded microRNAs in heart failure and hypertrophy (ROLE OF CARDIAC SOX6)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2012-01-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 221920.0
EU funding (EUR): 221920.0
Participants: 1
Project status: CLOSED

MicroRNAs (miRNAs) negatively regulate gene expression by promoting mRNA degradation and inhibiting mRNA translation. Recent studies have uncovered key roles of miRNAs as mediators of cardiovascular development and disease, but much remains to be learned about their mechanisms of action and regulation. Dr. Olson's lab has described a family of muscle-specific miRNAs, referred to as MyomiRs, which are encoded by introns of myosin heavy chain genes. These three miRNAs (miR-208a, miR-208b, miR-499) control pathological cardiac remodeling, muscle myosin content, myofiber identity, and muscle performance. Each of these miRNAs regulates the expression of Sox6, a transcriptional repressor. Consistent with a role for Sox6 as a mediator of the actions of MyomiRs, over-expression of Sox6 in skeletal muscle mimics the effects of MyomiR gene deletion and deletion of Sox6 in skeletal muscle recapitulates the phenotype of MyomiR over-expression. These findings have revealed a previously unrecognized role for Sox6 as a mediator of skeletal muscle gene expression, but nothing is known of its potential role in the control of cardiac gene expression or function. Given the importance of MyomiRs in regulating cardiac stress responses, and the regulation of Sox6 expression by MyomiRs, we postulate that Sox6 is a central regulator of cardiac hypertrophy and heart failure. The goal of this project is to define the mechanisms whereby Sox6 controls cardiac gene expression by idenfication of its downstream target genes and transcriptional cofactors and to explore its role as a mediator of the actions of myosin-encoded cardiac miRNAs. The project will benefit from a strong foundation of preliminary data and unique mouse strains (e.g. Sox6 knockout and transgenic mice) already established in the lab. These studies promise to provide important new insights into the gene regulatory mechanisms in heart disease and to potentially reveal new therapeutic targets for modulation of cardiac function.

Keywords: cardiology,cell biology,molecular genetics
Regulation of mammary epithelial morphogenesis by microtubule plus-end tracking proteins (3D HMEC-MT-TIP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 176685.6
EU funding (EUR): 176685.6
Participants: 1
Project status: CLOSED

The mammary gland functional unit develops as a result of a complex morphogenetic process organizing polarized epithelial cells into a branched network of ducts terminating in acini. Most of human breast cancers originate from transformation of epithelial cells and induce breakdown of this structure. Studies in cells grown in two-dimensional (2D) cultures have shown that microtubules target and regulate actin network and adhesion complexes, which are also known to be essential components of three-dimensional (3D) tissue architecture. Here, I propose to address microtubule functions and behavior in a more relevant system to model physiological morphogenesis. For this purpose, I intend to investigate mechanisms underlying the regulation of microtubule dynamics and their biological impact in an in vitro reconstituted acinar model of untransformed mammary epithelial cells grown in 3D. My project aims at addressing the role of the growing family of microtubule plus-end tracking proteins (+TIPs) in the control of microtubule functions during 3D mammary epithelial morphogenesis. Special focus will be given to +TIP-dependent microtubule cross-talk with key structural components of acinar architecture. Imaging of microtubules in 3D mammary epithelial culture will be used to analyze microtubule behavior during epithelial-mesenchymal transition and the role of +TIPs in this process.

Keywords: microtubule,3d imaging,human mammary epithelium,morphogenesis,breast cancer
Paricle Flow in Heavy-Ion Collisions with CMS (PF4CMSHI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 116402.4
EU funding (EUR): 116402.4
Participants: 1
Project status: CLOSED

The proposed research entails the study of the Quark-Gluon Plasma (QGP) which will be created in heavy-ion collisions at the Large Hadron Collider (LHC). We propose to apply particle-flow event reconstruction, a powerful technique shown to improve the capabilities of the CMS (Compact Muon Solenoid) detector in p+p collisions, to heavy-ion collisions for the first time. Using this method, the researcher will study parton energy loss in the QGP by full reconstruction of jets in heavy-ion collisions, a challenging measurement which stands to benefit from the particle-flow methodology. We further propose to improve the electron reconstruction capabilities at low transverse momentum and large occupancy, again using particle flow. Doing so will contribute to the measurement of the Z boson, a first in heavy-ion collisions, as well as the measurement of the Upsilon family of bottomonium states, which are expected to act as a thermometer of the system via their sequential disassociation with temperature. Finally, the researcher will devise measurement strategies for upcoming high-luminosity data-taking by designing and testing triggering algorithms for jets and electrons in heavy-ion collisions. The applicant is an experienced researcher stationed at CERN for the last year. His previous research was carried out in the U.S. at the RHIC facility. He seeks to further integrate into the European scientific community through a fellowship at one of the premier institutes for nuclear and particle physics research, the Laboratoire Leprince Ringuet. This fellowship will serve to reinforce the CMS heavy-ion program, increasing European excellence by providing a complimentary and competing effort to the ALICE experiment. Further, the fellowship will serve to strengthen European participation in the CMS heavy-ion program, which is currently dominated by non-European institutes.

Keywords: physical sciences,physics
The interplay between astrocytes and neurons in the progression of stress-induced cognitive disorders (STRESSEDASTROCYTES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-12-03
End date: 2014-12-29
Duration (months): 24.0
Total project cost (EUR): 153047.2
EU funding (EUR): 153047.2
Participants: 1
Project status: CLOSED

Stress exposure sets primarily a response to restore physiological homeostasis and promote behavioural adaptation. However, prolonged stressful experience may trigger maladaptive responses that lead to severe manifestations such as depressive-like behaviour, learning and memory deficits. Indeed, advances in neurobiology reported clear morphological deficits in neurons of both hippocampus and prefrontal cortex (PFC) after chronic-stress exposure. However, the classical paradigm that brain information processing is exclusively a neuronal process has been challenged by an emerging body of evidence. In fact, there is a lack of information regarding stress effects on glial cells, whose importance is rising due to exciting data supporting dynamic neuron-glia interactions. Blockade of neurotransmitter release from astrocytes in vivo contributed to unexpected behaviour modulation, namely affecting sleep control. Moreover, ex vivo immunohistochemistry pointed out astrocytic loss in regions affected by stress exposure. In light of these thrilling observations, it is predictable that astrocyte function may be implicated in stress-induced cognitive impairments. Therefore, we propose here the multidisciplinary and innovative dissection of the astrocytic contribution to the progression of stress-related cognitive disorders across the PFC and hippocampus by: (1) assessing the extent of the stress-induced effects, through a battery of behaviour tests for cognitive and depressive-like behaviour, after conditioned genetic or pharmacological blockade of astrocytic function; (2) combining three complementary electrophysiological in vivo techniques and producing a thorough characterization of the astrocytic contribution to stress-induced changes throughout time; and (3) associating ex vivo patch-clamp recordings and a comprehensive immunohistochemical analysis to reveal specific morphological implications in the disorder progression, both in neurons and astrocytes.

Keywords: neurophysiology
Revealing the response of the coral and its endosymbiotic algae to climate changes by molecular techniques (CORALCLIMRESPONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 225006.4
EU funding (EUR): 225006.4
Participants: 1
Project status: CLOSED

Tropical coral reefs shelter a high rate of marine biodiversity and provide a sizeable amount of ecological services. These ecosystems of interest face tremendous and pervasive challenges from human demography sky-rockets and inherent development pressures, as well as climate change and associated sea level rise. Prospects of coral reefs conservation, critically inevitable, will achieve through the growth of understanding their ecological mechanisms. The basis for the existence of tropical coral reefs is a mutualistic relationship between the coral polyp and its endosymbiotic dinoflagellates, the Zooxanthellae (Symbiodinium spp.). Due to the consequence of global warming coral bleaching became one of the most important threats to coral reefs in the last decade. The higher temperatures and solar radiation disrupt photosynthesis in the coral’s symbiotic algae and result in the production of toxic free oxygen radicals that cause the corals to eject the algae. These stressed corals have lost their major source of energy and are effectively starving. Some corals can regain their algae and recover; but the increased stress often results in lethal coral diseases or reduced coral reproduction and growth during the next year. Surprisingly although bleaching events have been intensively studied worldwide little is known about the origin of algal rejection or the involved signalling pathways. The main objective of this innovative and original proposal is to investigate for the first time the role of the organelles of host and symbiont in coral bleaching via immunoflourescence during stress experiments. In addition, gene expression analysis will elucidate candidate genes that might be involved. This original project will lead to a better understanding of mechanism taking place during bleaching of the coral holobiont and will therefore enhance the European excellence in coral scientific community while studying this so far unknown field.

Keywords: corals reefs,french-polynesia,dinoflagellates,gene expression,cytology,organelles,communication,coral bleaching,marine biodiversity,climate change,oxidative stress,symbiont
QUANTUM DYNAMICS AND ENTANGLEMENT IN COMPLEX MANY-BODY SYSTEMS (QUANTUM DEMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 161663.2
EU funding (EUR): 161663.2
Participants: 1
Project status: CLOSED

Quantum information science is a relatively young scientific discipline. However, the concepts and tools initially developed within this rapidly expanding field for the implementation of quantum computation have turned out very useful to provide both new physical insight and novel computational techniques relevant to different disciplines of physics. In this research project, we will extend these concepts and tools to the study of complex many-body systems, including condensed matter systems and chemical/biological complexes, from the perspective of identifying processes exhibiting quantum speedup and entanglement-based enhancement. We will investigate the relations between entanglement and the speedup of a quantum computation in condensed matter systems. Our aim is to characterize the possible functional role of coherence and entanglement for quantum enhancement in certain chemical/biological processes.

Keywords: quantum mechanics,chemical physics,quantum entanglement,quantum computation,quantum speedup,quantum biology,condensed matter physics