Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Interactions, Spins and Edges in Optical Lattices with Topological Band Structures (ISOTOP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-01
End date: 2018-07-29
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Electrons in a magnetic field experience a drift transverse to their velocity, which gives rise to intriguing effects such as the whole family of Hall Effects. Interestingly, this drift can also appear without a charged particle and without magnetic field, i.e. for ultra-cold quantum gases in optical lattices with non-trivial topology, described by a Berry curvature. This enables researchers to use the tunability of quantum gases and allow for studies beyond the possibilities of condensed matter systems. Furthermore, it allows to mimic and study in great detail fascinating effects such as topological insulators and edge-states. Especially, the interplay between topology and interactions is not well understood and the existence of many interesting states, such as topological insulators, fractional Chern insulators and topological superfluids, is predicted, but have not yet been observed. In recent years, great progress has been made in engineering topological band structures for quantum gases. Whereas theoretical proposals are well developed, so far there are only few experimental realizations of topological band structures, especially for fermionic quantum gases. In this action, we want to create non-trivial topological band structures and explore (many-body) phases that can emerge for fermions and mixtures of bosons and fermions. We will map out the Berry curvature and study the detection of edge states, which provides a clear signature of a non-trivial topology. For the first time, we will realize a new creation and detection method for topological band structures and study high spin Fermi systems in topological optical lattices.

Keywords: ultra cold atoms,quantum gases,fermions,optical lattices,band structure,topological band structure,berry phase,berry curvature,edge states,high spin
USE OF LACTIC ACID BACTERIA AS DELIVERY VEHICLE FOR ORAL VACCINATION OF FISH (LABVaccFish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-04
End date: 2018-01-03
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

This project will provide a proof of principle that food-grade lactic acid bacteria (LAB) can be used as vehicle for oral vaccination of fish and will unravel the underlying mechanisms of memory formation in zebrafish. We will engineer Lactococcus lactis to deliver a DNA- or protein-based prototype vaccine against spring viraemia of carp virus (SVCV). The choice of virus and antigen is based on work showing that injection vaccination with DNA plasmids encoding the G protein of SVCV is highly successful. This vaccination route however, is less suitable for mass delivery and alternative strategies aiming at delivering the vaccine via the oral route are required. Food-grade lactic acid bacteria as vaccine vehicle are an attractive strategy to deliver vaccines at mucosal surfaces that has never been investigated in fish. We will use zebrafish as animal model to monitor real-time vaccine uptake and kinetics of immune responses. Already available knock-out and transgenic zebrafish lines expressing reporter genes under the control of cell- or cytokine-specific promotors will help dissect the contribution of innate and adaptive immune responses induced by vaccination. We will develop novel transgenic zebrafish lines for the controlled ablation of zebrafish cytotoxic T lymphocytes (CTL), to test the hypothesis that long term protective immunity to SVCV is mainly CTL-mediated. Altogether, this project will provide a proof of principle for the development of mucosal vaccines suitable for mass delivery in fish using commensal bacteria, supported by the unravelling of immune mechanisms important for memory formation using zebrafish as animal model. This project will familiarize the candidate with mucosal immunology using state-of-the-art techniques such as transgenesis and live microscopy in an animal model of high interest to the Life Sciences; this will promote his development as independent researcher and facilitate the acquisition of a stable research position in Europe

Keywords: zebrafish,vaccination,immunology,mucosal immunity,microbiology,virology,dna vaccin
Torsion units of integral group rings (ZC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2017-10-31
Duration (months): 18.0
Total project cost (EUR): 118591.2
EU funding (EUR): 118591.2
Participants: 1
Project status: CLOSED

Group rings form one of the most significant classes of rings. They encode group and ring theoretical information. The study of the group of units of integral group rings was initiated in the 1940's by Higman in connection with the Isomorphism Problem. One of the main problems still unsolved is the description of its torsion units of the the torsion elements of the group V(ZG) formed by the units of augmentation 1. The Zassenhaus Conjecture, possed in the 1960's by Hans Zassenhaus, predicts that all the torsion units of V(ZG) are conjugate in the rational group algebra of the elements of G. This has been proved for some classes of groups, as for example, nilpotent or cyclic-by-abelian groups and for some special groups. A weaker conjecture stablishes that the orders of the torsion units of V(ZG) and G are the same, or the even weaker Prime Conjecture which states that V(ZG) and G have the same prime graph. The aim of this proposal is to make significant contributions on this questions. More precisely, we will concentrate in studying the above questions for G metabelian and for some series of simple groups as, for example, the projective linear groups. We intent to develope new techniques which surpasses some of the obstacles founded using the existing methods as for example the HeLP Method. Some recent progress obtained recently by the applying researcher, as the Lattice Method introduced in his Ph.D. Thesis and a software developed in cooperation with A. Bächle implementing the HeLP Method, would be very useful to obtain the goals of the project.

Keywords: group rings,units
Reasoning about Physical properties Of security Protocols with an Application To contactless Systems (POPSTAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1499750.0
Participants: 1
Project status: CLOSED

The shrinking size of microprocessors as well as the ubiquity of wireless communication have led to the proliferation of portable computing devices with novel security requirements. Whereas traditional security protocols achieve their security goals relying solely on cryptographic primitives like encryptions and hash functions, the protocols employed to secure these devices establish and rely in addition on properties of the physical world. For instance, they may use, as basic building blocks, protocols for ensuring physical proximity, secure localisation, or secure neighbourhood discovery. Unfortunately, we often hear about ill-conceived systems, and portable computing devices raise some serious concerns about privacy.To draw meaningful conclusions, the security analysis of these systems has to be done taking into account physical properties, such as transmission delay, network topology, and node positions. This contrasts sharply with standard models used to analyse traditional protocols. The main objective of the POPSTAR project is to develop foundations and practical tools to analyse modern security protocols that establish and rely on physical properties. In particular, we will: - devise models and develop techniques to make possible a rigorous analysis of cryptographic protocols that establish and rely on physical properties; - develop foundations and practical tools for formally verifying security properties, as well as privacy properties that play a prominent role is many applications; - experiment the developed techniques for analysing the security of modern contactless systems. The POPSTAR project will significantly advance the use of formal verification to contribute to the security analysis of protocols that rely on physical properties. This project is bold and ambitious, and answers the forthcoming expectation from consumers and citizens for high level of trust and confidence about contactless nomadic devices.

Keywords: formal methods,symbolic models,verification,cryptographic protocols
Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials (PePiPOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Antimicrobial resistance is an increasingly serious threat to global public health and immediate action must be taken to prevent its ever-increasing spread. One approach to overcome this problem is the development of new materials and coatings with bactericidal action; in particular those which tackle biofilm formation specifically. By inhibiting the growth of biofilms, bacteria become more sensitive to treatment and resistance diminishes. The applicant has designed PePiPOM to develop peptide-functionalized polyoxometales (POMs) that possess synergic bactericidal activity. The PePiPOM materials combine the anti-aggregation activity of POM molecules (key to tackling growth of biofilm matrix) with the bactericidal effect of POMs + antimicrobial peptides (to rupture bacterial cell membranes and/or internalise and destroy bacterial cells). Central to the success of this proposal is a novel approach for the synthesis of POM-hybrids whereby an “on-POM polymerisation” will be used to produce peptide-POM hybrids. The design of the antimicrobial peptides will also play a key role in the success of the project, since they will provide the required properties for an improved and synergistic activity. The resulting PePiPOM biofilm inhibitors will be tested for both their anti-aggregation and antibacterial activity, and the most effective candidates will be evaluated as anti-biofilm agents on plastic and metal surfaces. The fundamental academic aspects of these results will be of interest to the chemistry and microbiology communities and their application of great relevance to industry and the general public. The PePiPOM MCSA will open new research horizons for hybrid materials with synergic antimicrobial properties, but also importantly, will offer a real boost in the career development of the applicant on her route to achieving her professional career objectives.

Keywords: polyoxometalate,hybrid materials,biofilm,antimicrobial resistance,peptide engineering
Establishment of P-element silencing in Drosophila simulans dysgenic males (P-MaleReg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-16
End date: 2021-04-15
Duration (months): 27.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Transposable elements (TEs) are mobile genetic parasites infecting the genomes of most organisms, so abundantly as to be a major determinant of genome size in eukaryotes. They can be harmful, as their ability to mobilise makes them highly mutagenic and a threat to host genome integrity. Hence, organisms have evolved several TE repression mechanisms, especially in the germline, where new mutations can be transmitted to progeny. TEs challenge these silencing strategies by invading new genomes through horizontal transfer, but hosts appear to rapidly adapt to these new TEs. The classic example is the invasion of the Drosophila melanogaster genome by the P-element: TE repression in this system evolved so quickly that the P-element and its repressors (recently discovered to be due to a small RNA pathway) appeared almost simultaneously. The selective pressure may have been intense: crosses between D. melanogaster males containing P-elements and females devoid of it lead to frequent F1 sterility and other aberrant traits. This phenomenon, associated with uncontrolled P-element mobilization, is named “hybrid dysgenesis”. Due in part to its rapidity, little is known about the early stages of TE repression evolution. In this work, we propose to take advantage of a rare opportunity to study the adaptation to a TE invasion in real time. Less than a decade ago, the P-element invaded the genome of D. simulans, a sister species of the genetic model. We aim to disentangle the molecular mechanisms involved in the establishment of P-element silencing in D. simulans. In particular, we will study the effects of dysgenesis and repression in males, which have been largely neglected to date. As a result, their role in the rapid spread of the P-element remains elusive. This work will contribute to deciphering how TE silencing is established during novel TE invasions, a crucial part of understanding the dynamics between TEs and their hosts.

Keywords: drosophila,transposable elements,evolutionary genetics,host parasite coevolution
A new clinically proven and reliable medical solution for continuous heart arrhythmia and blood pressure monitoring (CARDIACSENSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Atrial fibrillation (AF) is the most common heart arrhythmia in adults and a major risk factor for ischaemic stroke (increased by 500%), costing globally around €500Bn/year. On the other hand, Hypertension (HTN) is a condition, mostly encountered in patients suffering from AF, although only half of these individuals have this condition under control, and only 20% are unaware that they have HTN. Besides the health risks associated with these conditions, there is a lack of non-obtrusive, non-inflating, non-invasive, small, precise, easy-to-use devices for continuous monitoring of vital signs, including AF and blood pressure. Cardiac Sense Ltd is an Israeli start-up established in 2009, with a vision of developing innovative non-invasive technology for monitoring vital signs. We are developing CardiacSense (TRL6), a clinically-proven medical solution that reliably delivers non-invasive and non-inflating heart arrhythmia and blood pressure monitoring, 23/365 for as long as needed. It mainly consists of a wearable (a watch), highly sensitive, error-free (introducing an artefact sensor), real-time measuring device, that is non-invasive (no surgery needed), easy to use (no training needed) and allows for a great connectivity (providing easy data storage and sharing). Our solution is based on optical PPG sensor technology to monitor heart AF and BP. In addition, we are the first company to develop a unique artefact sensor that detects finger and wrist movements that affect the PPG signal by increasing false positive results. Our solution thus has a medical grade accuracy level of pulse measurement. Through this project we aim to finalize its development and launch it to the market, with a potential to save around €800M to EU healthcare and save up to 5,000 lives yearly, and to boost our company's growth to +€7.5M revenues, and +20 new jobs by 2025.

Keywords: e health,digital health,wearable,medical device,monitoring vital signs,heart arrhythmia,atrial fibrillation,blood pressure,hypertension,cardiac disease
CHronic exposure scenarios driving enviRONmental rIsks of Chemicals (CHRONIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Switzerland,Belgium,France,Netherlands,Netherlands,Denmark,Portugal,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 3627872.64
EU funding (EUR): 3627872.64
Participants: 10
Project status: SIGNED

CHRONIC aims at delivering a cohort of highly-skilled and informed future research leaders trained in understanding and integrating, into risk-assessment practice, the long-term, low-dose chronic chemical exposure and their interactions with other environmental stressors. CHRONIC research will support improved decision-making in risk assessment based on uncertain and potentially conflicting information, and in the development of scientifically-based monitoring strategies. The focus on low chronic exposure to contaminants in different environmental organisms (macrophytes, invertebrates, vertebrates) and end-of-line systems (freshwater, sediment, soil) allow for a training that is broader than that achieved from conventional narrower one-system concept generally included in PhD-programmes and in standard protection goals. Thus, CHRONIC represents a paradigm shift in ERA methods and practices needed to deal with current and future contaminant challenges. CHRONIC will include 13 PhD projects aimed at developing tools and approaches to identify relevant nonstandard modes of toxicity for low chronic chemical exposure and integrate these with environmental stressors. CHRONIC includes academic institutions, research centres, government institutions, SMEs, and an NGO all with extensive experience in education and training and a high state-of-the-art scientific and technical expertise and infrastructure. The program will therefore lay the basis for an integrated approach to environmental risk assessment that includes non-standard yet ecologically relevant endpoints and low chronic exposure as key elements. CHRONIC include training-by-research, joint courses covering technical, scientific, ethical, and transferable skills. Students will also engage actively in communication to scientific and public communities and be enrolled in an ambitious intersectional networking exchange plan to increase employability and provide a broad perspective to their future career plan.

Keywords: long term low contaminant exposure,non standard endpoints,behavioral,immuno modulation,genotoxicity,adverse output pathway aop,transgenerational impact,epigenetics,environmental,stressors
BIO-Based pESTicides production for sustainable agriculture management plan (BIOBESTicide)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Italy,Italy,Spain,Poland,France,France,France,France,France
Call: Demonstrate bio-based pesticides and/or biostimulant agents for sustainable increase in agricultural productivity (H2020-BBI-JTI-2019, 2019)
Start date: 2020-05-01
End date: 2023-10-31
Duration (months): 42.0
Total project cost (EUR): 4402772.5
EU funding (EUR): 3069653.0
Participants: 11
Project status: SIGNED

The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. GREENCELL, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. BIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). The BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas. To assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. A Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products. The adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.

Keywords: biopesticide,grapevine trunk diseases,biomass,p oligandrum