Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Higher-Order Networks and Dynamics (BeyondTheEdge)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands,Hungary,Portugal,Germany,Italy,France,Spain,Türkiye,Brazil,United States,United Kingdom
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2664926.74
EU funding (EUR): 2553739.2
Participants: 19
Project status: SIGNED

Many systems that govern our everyday lives—from communication networks to the human brain—can be seen as networks of interconnected units. Traditionally, networks are equated with graphs where edges give pairwise relations between two units. However, in network dynamical systems, nonlinear higher-order interactions between more than two units often play a critical role in shaping the collective dynamical behaviour of all units: For example, the spread of a disease depends not only on our behaviour as pairs of individuals but also how we behave in groups of more than two. Thus, elucidating the role of these higher-order interactions is critical to understand and control the dynamics of complex systems that determine our lives and livelihoods, whether it is the spreading of a disease or the proper functioning of the human brain as a network of billions of neurons. The doctoral network BeyondTheEdge will identify the role of nonpairwise higher-order interactions in the emergence of complex dynamical behaviour of networks of interacting units. BeyondTheEdge brings together key researchers in an international network that is interdisciplinary (from mathematics to neuroscience) and intersectorial (including academia, private research institutes, and industry) to develop new mathematical insights relevant for real-world problems. BeyondTheEdge will train a cohort of 10 PhD students through research, education, and complementary skills training. This will enable the PhD students to innovate, collaborate, and become leading professionals in academia, industry, or the public sector: Innovative training activities will ensure that all PhD students can apply their skills beyond the academic context and put them in perspective of the wider world. Supervisor training activities ensure that the more junior project partners can shape the PhD education of the future. Thus, BeyondTheEdge will make a lasting contribution that will far outlive the duration of the project.

Keywords: dynamical systems,networks,higher order interactions
Accelerating TRAnsformation through Capitals Knowledge (A-TRACK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Spain,Belgium,United Kingdom,Switzerland,Netherlands,Germany,Ireland
Call: Natural capital accounting: Measuring the biodiversity footprint of products and organizations (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 6485805.09
EU funding (EUR): 6332130.09
Participants: 11
Project status: SIGNED

The overall goal of A-Track is to consolidate and mainstream activities to accelerate transformation in organisations, such that, by end of project, a critical mass of businesses, financial institutions, and governments, integrate the value of natural capital in their decision-making, helping to halt and reverse biodiversity loss. In doing so, A-Track will contribute to delivery of the European Green Deal. A-Track builds on existing initiatives and best practice to develop, pilot, test, demonstrate and scale innovations in this space. Specifically, A-Track will: (1) develop and demonstrate the use of robust information pathways that facilitate flows of biodiversity information for use in business and financial decisions, and the compilation of public and private sector natural capital accounts; (2) strengthen the life cycle assessment of biodiversity and ecosystem services footprints for products and organisations, integrating and further mainstreaming these with natural capital approaches and materiality assessment practices; (3) mainstream and advance natural capital assessment and accounting in businesses and their integration in decision-making across key sectors and business functions; (4) facilitate and incentivize the adoption and scaling of nature-positive business models; (5) nurture financial innovations to scale nature-positive finance based on reliable natural capital data and practice. Emphasis is placed on integration, synthesis and wide engagement across this work. This will deliver wider impacts, in Europe and beyond (through global value chains), in terms of enhanced natural capital and biodiversity, enhanced competitivity of European businesses in the new nature economy, and improved wellbeing derived from enhanced ecosystem services. A-Track brings together an intersectoral and interdisciplinary consortium of leading players who are involved in many of the key related front-runner initiatives across this space, ensuring appropriate synergies.

Keywords: natural capital assessment,natural capital accounting,ecosystem accounts,environmental footprint,nature positive business models,nature positive investment,european green deal transition
Psychiatric disorders and Comorbidities caused by pollution in the Mediterranean area (PsyCoMed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Malta,Italy,Poland,Spain,Tunisia,Egypt,Lebanon,Australia,Morocco
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1220314.29
EU funding (EUR): 1159200.0
Participants: 14
Project status: SIGNED

The PSYchiatric disorders and COmorbidities caused by pollution in the MEDiterranean area (PsyCoMed) project proposes a MSCA-Staff Exchange program that aims to characterise the role of anthropogenic pollutants in the Mediterranean area as a risk factor of neuropsychiatric disorders and associated pathologies, and the role of neuroinflammatory responses in the disease progression. The consortium comprises 11 beneficiaries (8 academic, 3 SMEs) and 3 TC partners putting together complementary expertises in environmental and life sciences (academics) and analytical biology or natural therapeutic phytocompounds (SMEs). Through a multi-scale (from molecular to clinical science), multi-modal (from mechanistic to behavioural approaches), and inter-sectoral strategy, PsyCoMed will correlate the effects of pollutants on psychiatric symptoms with alterations of inflammatory pathways in animal models and psychiatric patients. We will investigate neural mechanisms underlying pathological changes in vitro and in in vivo preclinical models. Natural substances with therapeutic potential will be tested for their ability to restore healthy mechanisms and alleviate pathological symptoms in animal models. PsyCoMed offers a unique framework to build a network synergy by bringing together themes and scientific practises in the Mediterranean area. The partners will share knowledge/know-how through secondments and workshops in support of PsyCoMed scientific objectives. This will improve the skills of staff members and their opening to the academic and private sectors. By proposing common protocols and experimental design, the participants will foster standardization of experimental procedures and diffusion of good laboratory practise. At a global level, the consortium will acquire the capacity to tackle complex neurobiological challenges, while building long-lasting collaborations. PsyCoMed will provide decision-makers with the ground for public health orientations with societal impact.

Keywords: pollutant mediterranean basin animal models psychiatric patients anxiety depression substance abuse epilepsy pain inflammation brain neuronal activity neural networks therapeutic agents
Games Realising Effective and Affective Transformation (societal and cultural domains) (GREAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Austria,Spain,Cyprus,China,South Africa,United Kingdom
Call: Games and culture shaping our society (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 1743947.5
EU funding (EUR): 1743947.5
Participants: 9
Project status: SIGNED

Games Realising Effective & Affective Transformation (in Societal and cultural domains) Research and innovation in the GREAT project will generate new knowledge of the actual and potential impact of games on European society and new understandings of the innovative uses of games to support the social engagement of citizens. Leveraging the central role of games in contemporary culture, it combines academic studies and practical experimentation with novel applications of games. Using collaborative design and citizen science methods, it brings together researchers with expertise in the areas of games, data analytics, and policy in an integrated investigation, articulated by case studies of the use of games in facilitating dialogue between citizens and policy stakeholders (policy makers, policy implementers, political parties, campaigning organisations and affected citizens). The context for the research is the climate emergency, and each case study is a research cycle addressing a policy issue and research questions, with multiple pilots and quantitative and qualitative research activities. An important aspect of the method is to place games in an authentic context, so that players are aware that their activities have real-world implications, and to close the loop by including interactions with policy stakeholders. Agile methods are applied to adapt games from existing platforms, for use as research tools: (a) short games deployed at scale in hit mobile games, generating quantitative data and reaching 3 million players, and (b) longer collaborative games based around social dilemmas with small groups, generating in-depth qualitative data. Research outcomes include publication of research findings in journal papers, a method for using games to rapidly obtain data and insight for policy stakeholders, technical resources and guidance for adoption, and implementation of the method.
TELLchloroplasts - Trafficking of news on Extracellular Latest Likely danger to chloroplasts (TELLchloroplasts)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Plants have evolved a sophisticated system to perceive and transmit external stimuli to the cell interior and inform growth and defense. The host lab discovered a new pathway linking the PM to chloroplasts and regulating defence, based on inducible protein re-localization, co-opted by pathogens during evolution. Both the plant protein CALCIUM DEPENDENT PROTEIN KINASE 16 (CPK16) and the viral protein C4 from tomato yellow leaf curl virus re-localize from the PM to chloroplasts upon activation of pathogen associated molecular pattern (PAMP)-triggered immunity (PTI); from the organelle, CPK16 acts as a positive regulator of downstream defence responses, while C4 acts as a suppressor. However, the molecular and cellular events enabling and regulating protein trafficking from PM to chloroplasts remain elusive. Preliminary data in the host lab found the colocalization of C4 with SYP61- and Ara7-positive compartments upon flg22 treatment; among them, C4 colocalizes with Ara7 at the periphery of chloroplasts. Upon flg22 treatment, CPK16 was also able to form mobile dots in the cytoplasm. These results suggest that endocytosis is likely to be involved in C4/CPK16 trafficking from the PM to chloroplasts. In addition, phosphorylation regulation and N-terminal cleavage could also regulate the PM-to-chloroplast protein trafficking as evidenced by mass spectrometry analyses. In this project, I will utilize both CPK16 and C4 to investigate the molecular determinants underlying the protein trafficking from the cell surface to chloroplasts, including how proteins are transported from the PM to chloroplasts (Objective 1) and how N-myristoylated C4 and CPK16 are released from membrane compartments prior to chloroplast import (Objectives 2). By using cell biology, protein biochemistry, molecular biology, and plant genetic methods, this project will expand our understanding of the PM-to-chloroplast protein trafficking and serve as stepping stone for the engineering of immune responses.

Keywords: geminivirus plant defense membrane trafficking endocytosis chloroplast
EquestRian OffIcers as an Innovative Tool for Developing a MiDdle-out Approach to Roman ImpERial EliteS (1st-3rd AD) (RIDERS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Roman society is elitist by nature and is thus represented by most available sources. Roman imperial elites have been long investigated, however scholars usually focused only on the two extremes of elites, either the top level (elites employed in high imperial administration), or the bottom one (civic elites). No attention was devoted to investigating the existence of a “middle-elite”. The RIDERS project offers an innovative investigation of Roman imperial elites with the ambitious purpose of changing traditional models of interpretation, moving beyond a top-down approach (i.e. focusing on the top level) and a bottom-up one (i.e. focusing on the bottom level), by developing a ground-breaking middle-out approach. After over three decades since the last complete work devoted to equestrian officers, the RIDERS project re-addresses the entire corpus of the 2,500 equestrian officers currently known, to develop an innovative tool for an in-depth investigation of imperial middle-elites. By applying a multidisciplinary methodology, based on traditional prosopography integrated with sociological methods and supported by digital humanities, the RIDERS project will develop, as its main outcomes, the first database devoted to equestrian officers and the first monograph on imperial middle-elites. The ambition of the RIDERS project consists in applying also to elites the social concept of “middle”, usually employed only for the remaining part of society. Suggesting that even elites had a “middle”, not only a top or a bottom, will ambitiously contribute to improving our knowledge of Roman society, which was much more complex and variegated than studies have hitherto highlighted.

Keywords: equestrian officers ordo equester roman imperial elites roman imperial administration roman imperial society
Espoo – leading a tide of systemic innovation (Espoo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Capital of Innovation Awards
Action type: Recognition Prize
Countries involved: Finland
Call: The European Capital of Innovation Awards (iCapital) (HORIZON-EIC-2024-ICAPITAL-PRIZE-02, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Espoo –Innovation isn’t just about creating something new, it should be about opening streams of wellbeing for the people and planet, developing into smarter solutions and better living – happiness. What the world needs is a systemic change that organically spreads social inclusion and equity for all. That gives everyone safety and a place to belong. Simply leaning towards a more sustainable way of life for the people and planet. That’s what Espoo is about: a leading innovation hub that creates the kind of innovation the world needs. This is true in Espoo where we quite probably 1) have the world’s most concentrated district for systemic innovation. The place to be is the greater Otaniemi district which may be a small area but that throws sparks of innovation all over our culture. It is a dense hub of over 400 R&D units, top-tier universities in business, design, and technology, and leading companies. Together with Aalto University and VTT, Espoo fosters systemic innovation by uniting startups, students, researchers, and citizens to innovate for a better future.a2) We have an area with the highest positive handprint per capita on the planet’s future, meaning regardless of their line of work, people here are continuously contributing to saving the world. And 3), we maintain the smallest gap between organizations' and individual values. Ideas flow through our innovation community like tides, carrying the excitement of people and leading to better quality of life. We do have another reason to stay ahead of the curve. Finland shares a 1,340 km border with Russia, the longest in the EU. The war in Ukraine, instigated by Russia, has raised serious concerns about the state of security throughout Europe. Our quest to defend the well-being of people is our utmost incentive to be innovative.

Keywords: icapital24
Climate-aware Resilience for Sustainable Critical and interdependent Infrastructure Systems enhanced by emerging Digital Technologies (ReCharged)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Switzerland,United Kingdom,Netherlands,Italy,Cyprus,Romania,Portugal,Spain,United States
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1381971.43
EU funding (EUR): 1117800.0
Participants: 15
Project status: SIGNED

ReCharged is a transformative project that has the vision to develop a new integrated framework toward a practical visualisation platform in order to optimise and streamline climate resilience and whole-life carbon emission assessments for interdependent Transport and Energy Systems, Lifelines and Assets (iTESLA). To achieve this, ReCharged harnesses the power of digital technologies and data to quantify the functionality and recovery of iTESLA after hazards. This is in response to the lack of methods of assessment and communicable visualisations of consolidated climate resilience and whole-life carbon emission metrics for iTESLA. ReCharged will account for interdependencies that lead to failure propagation in transport and energy systems, to accelerate post-hazard recovery, mitigate losses and societal ramifications due to climate change. In doing so, ReCharged underpins synergies and participatory decision-making to combat siloed thinking in infrastructure management. This project will lead to 50% faster decision-making in iTESLA management, 50% reduction of carbon emissions for the two case studies analysed, create new jobs, and make Europeans fit for the Digital Age. ReCharged is a synergy that combines the exchange of interdisciplinary knowledge and tailored training of staff, through an alliance between leading academic institutions, industrial partners, SMEs, and a research and technology center. All beneficiaries are committed to exploiting and transferring their skills and knowledge, to incentivise data-driven resilience toward climate adaptation and reduce emissions in critical infrastructure. ReCharged will augment researchers’ skills and career perspectives, create a community of practitioners, improve critical infrastructure, and ultimately make people feel safer.

Keywords: climate resilience sustainability critical infrastructure digital technologies fragility risk transport energy social impact
Unlocking the Redox Code: Mapping the Molecular Mechanisms of Hypoxia Tolerance (URC-Hypoxia)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

Hypoxia, the condition of inadequate oxygen availability, has profound implications for life on Earth. It contributes to biodiversity loss and is a key factor in many human diseases, including stroke and other chronic diseases, such as heart disease, cancer and neurodegenerative disorders, which are leading causes of death and disability in the EU. The URC-Hypoxia project aims to explore the molecular mechanisms that enable certain organisms, like the waxworm Galleria mellonella, to be resilient to hypoxia. By studying how these organisms survive hypoxia through the "Preparation for Oxidative Stress" (POS) adaptive response, the project seeks to characterize the molecular mechanisms underlying POS. This knowledge might be relevant in finding biomarkers and putative target molecules to improve hypoxia-related human diseases. The project will test the hypothesis that early reactive oxygen species (ROS) production under hypoxia triggers redox-sensitive signaling pathways, leading to POS as part of the cellular stress response. This will be explored using transcriptomics, proteomics, and oxidative modification mapping techniques. Key objectives include: (1) Characterizing anoxia tolerance in Galleria mellonella and identifying key windows for redox signaling events; (2) Quantifying ROS production and pinpointing redox imbalance; (3) Identifying transcripts, gene networks, proteins, and oxidative modifications involved in the hypoxia response; and (4) Testing the feasibility of targeting these mechanisms to enhance hypoxia resilience in human cells. The methodology employs advanced tools like mass spectrometry, RNA sequencing, and imaging techniques, leveraging the host institution (i3S) specialized scientific platforms. The project is expected to provide new insights into the molecular basis of hypoxia tolerance, which could lead to innovative treatments for hypoxia-related diseases. It aligns with EU health priorities by addressing chronic disease management.

Keywords: anoxia,free radicals,glutathione,hypoxia,ischemia,neurodegeneration,oxygen,oxidative stress,reactive oxygen species,redox balance,stroke