Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A smart, energy autonomous, universal and cost-effective dynamic passenger information system (E-APIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Poland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PIXEL is a Polish B2B SME, a pioneer and market leader in the development and delivery of passenger information system in the Transport Sector. We operate in an industry that is expected to growth to $20.34 Billion by 2019 at a CAGR of 26.5%. We develop all our innovative products with the belief and values of freedom of mobility. Due to language barriers and the fact that only 19% of Europeans are bilingual the Public Transport needs to be innovative and leverage advances in Smart City and Intelligent Transport System technologies to attract more citizens and foreigners to use the Public Transport and facilitate freedom of mobility. To solve this problem we have created E-APIS, a smart, energy-autonomous, universal and cost-effective dynamic passenger information system that removes all communication barriers and radically improves freedom-of-movement in public transport across the EU Member States. The innovation lies in the integration of advanced displays and mobile communications that are able to provide real-time information in any chosen language and low-power technologies that allow 24/7 365 days of autonomous power through renewable energy sources. Our solution provides a high economic impact to Transport Operators since it removes energy bills and installation costs and gives them a new revenue stream. These qualities will shorten payback periods and make the investment sustainable and profitable. We foresee that E-APIS will add over €10 Million to our annual revenue by 2023, increase our annual profits by 25% and grow direct employment by 30% by 2021 (5 year ROI 14). Phase 1 of this innovative project is to carry out an elaborate Feasibility Study and Business Plan to get E-APIS from TRL6 to TRL9 and commercialise it.

Keywords: autonomous,smart,renewable energy
Mediterranean Coastal Resources: benefits and constraints for Prehistoric hunters-gatherers (MedCoRes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The Project “Mediterranean Coastal Resources: benefits and constraints for Prehistoric hunters-gatherers” aims to investigate how Mediterranean coastal ecosystems and climatic changes over the last 19,000 years have affected settlement and subsistence patterns during the Mesolithic-Neolithic transition. Studying past human adaptation in coastal zones is a key research topic to understand processes of economic intensification and human resilience to environmental change. We propose to reconstruct the evolution of coastal landscapes around a well-known Mesolithic settlement area through the multi-proxy analysis of sediment cores of Pego lagoon (Gulf of Valencia, Spain). The objectives are: (a) the reconstruction of environmental changes through geomorphological, sedimentological and geochemical analysis and fossils of aquatic fauna in a well-constrain chronology, (b) the identification of vegetation cover changes through the analysis of pollen, spore and charcoal, which are linked to climatic change and human land-use, (c) the reconstruction of the frequency of storm surge marine events using sedimentological analysis, and (d) the evaluation of ecosystems services and vulnerability to human pressures through a comparison of the inferred palaeoenvironmental dynamics with archaeological datasets from the same study area. The hosting laboratory IPHES (University Rovira i Virgili, Spain) is the ideal institutional environment to develop the proposed research during the course of the fellowship and beyond. The researcher will be integrated within, and trained, in a strong collaborative and multidisciplinary network. This fellowship will reinforce the research experience, transferrable skills and audience and outreach of the candidate, and will thus be crucial for her future career.

Keywords: landscape archaeology,coastal environments,sedimentary archives,multiproxy analysis,mesolithic,neolithic
Continuous Observation of Embedded Multicore Systems (COEMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Norway,Romania
Call: Software Technologies (H2020-ICT-2016-1, 2016)
Start date: 2016-11-01
End date: 2020-04-30
Duration (months): 42.0
Total project cost (EUR): 3961082.5
EU funding (EUR): 3961082.5
Participants: 8
Project status: CLOSED

The ability to observe the internals of an execution of a computer-based system is a fundamental requirement for ultimately ensuring correctness and safe behaviour. Within COEMS (Continuous Observation of Embedded Multicore Systems) a novel observer platform with supporting verification methods for software systems is created. COEMS tackles the issues of detection and identification of non-deterministic software failures caused by race conditions and access to inconsistent data. It gives insight to the system’s actual behaviour without affecting it allowing new verification methods. An efficient real-time access and analysis as a critical element for operating safe systems will be developed and validated by COEMS. Moreover, a cross-layer programming approach supporting failure detection will be proposed. COEMS aims at shortening the development cycle by considerably increased test efficiency and effectivity, by increased debug efficiency (especially for non-deterministically occurring failures) and by supporting performance optimization. COEMS improves the reliability of delivered systems, enabling software developers to identify, understand, and remove software defects before release, as well as improving efficiency of software for multi/many-core computing systems in terms of performance, real-time behaviour, and energy consumption. The two Global Players Thales Group and Airbus Group, both active in safety-critical domains, will validate the COEMS approach by suitable demonstrators, i.e. testing and debugging of real-world multicore applications. In addition to these two domains, we will address the domains of safety-critical medical applications, automation and automotive industry, as well as the Internet of Things. Technologically, COEMS will provide the world-wide first comprehensive online observation approach that is non-intrusive allowing improved testing and debugging. Altogether, COEMS will define a new state-of-the-art for software systems development.

Keywords: embedded systems,runtime verification,multicore,observation,debug,trace,safety critical,failures,software quality
Fatigue life prediction on Inco 718 part subjected to service induced damage (FLECTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,United Kingdom
Call: Fatigue life prediction on Inco 718 part subject to service induced damages (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 793628.75
EU funding (EUR): 649242.88
Participants: 3
Project status: SIGNED

FLECTION will (1) develop a state-of-the-art experimental methodology for a controlled experimental generation of NDS according to their type and geometrical morphology; facilities such as light gas gun, Hopkinson bar and drop weight will be used for the scope (2) characterise different type of NDS generated at different impact energies, sizes and morphology by means of micro-analysis facilities; (3) characterise the residual stresses and the microstructure around the NDS and will correlate them with the principal features of the NDS; (4) determine the effect of residual stresses and microstructure due to NDS on the fatigue performance of IN718; the material will be thorough characterise and a complex fatigue test campaign of the damaged material will be carried out to highlight the main parameters affect fatigue life; (5) develop, calibrate and validate state-of-the-art multi-scale computational models for the prediction of residual stresses around NDS and for the prediction of fatigue life of damaged material; (6) develop an uncertainty analysis to identify the key parameter affecting fatigue life and to quantify the uncertainty in the predictions of the computational models; (7) develop a comprehensive statistically robust numerical-experimental approach for the prediction of safe life in IN718 components; the experimental methodologies and the computational models will be integrated together. FLECTION will contribute to Clean Sky LPA by providing an approach to validate the selected blade design of the CROR engine. Furthermore, FLECTION contributes to the European objectives of: development of technology product differentiator from non-EU developers; reduction of green house emissions through increased fuel efficiency and weight reduction; enhanced mobility by creating cost-effective transport.

Keywords: safe life prediction,multi scale fatigue model,surface damage,control damage generation,impact,design of experiment
Safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS) (TUDCA-ALS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Italy,Belgium,France,Netherlands,United Kingdom,United Kingdom
Call: New therapies for rare diseases (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 5596928.0
EU funding (EUR): 5596928.0
Participants: 10
Project status: SIGNED

TUDCA-ALS will focus on amyotrophic lateral sclerosis (ALS) a rare neurodegenerative disorder, that affects motor neurons in the brain, brainstem and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. ALS has an estimated prevalence of 5.40 cases per 100.000 population corresponding at about 40.000 patients at European level. Treatments are modestly effective at best, and the majority of patients die within 3-5 years of diagnosis, often from respiratory failure. TUDCA-ALS is based on the results of a successful proof-of-concept trial and has the ambition to develop a novel therapy in patients with ALS, based on administration of tauroursodeoxycholic acid (TUDCA) in addition to riluzole. TUDCA-ALS aims to perform a state-of-art randomized control trial on safety and efficacy of TUDCA in patients with sporadic ALS, without cognitive involvement and to exploit the project results into a novel therapeutic treatment for ALS. The trial primary endpoint is deterioration of function measured with the ALS Functional Rating Scale Revised. The secondary endpoints are: (1) Survival time to invasive ventilation (tracheostomy) or death; (2) changes in quality of life parameters measured by the ALSAQ-40 questionnaire; (3) functional changes measured by Forced Vital Capacity, and the EQ-5D scale. Muscle force will be assessed by the MRC scale and a correlated analysis of function and survival will be performed. Two biomarkers will be measured: neurofilament levels in the CSF and serum and MMP-9 expression in serum. The latter is a possible biomarker of TUDCA efficacy. TUDCA-ALS is grounded on promising phase IIb clinical data and is expected to impact positively on the international research efforts on ALS. TUDCA-ALS aims to obtain concrete benefits for patients with ALS. If the trial will prove successful, the consortium will support the development of this treatment at European level by combining expert knowledge and patient cooperation.

Keywords: amyotrophic lateral sclerosis,disease modifying treatment,neuroprotection,deoxycholic acids
Security Assurance FramEwoRk for neTworked vEhicular teChnology (SAFERtec)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Israel,Greece,Hungary,Greece,France,Netherlands
Call: Assurance and Certification for Trustworthy and Secure ICT systems, services and components (H2020-DS-LEIT-2016, 2016)
Start date: 2017-01-01
End date: 2020-03-31
Duration (months): 39.0
Total project cost (EUR): 3819380.0
EU funding (EUR): 3819380.0
Participants: 12
Project status: CLOSED

The assurance of security, privacy, reliability and safety features is key-point to unlock the enormous potential that the connected vehicles systems paradigm i.e., the dynamic Cyberphysical system of highly-equipped infrastructure-connected vehicles with numerous third-party components, can offer towards safer transportation. The emerging systems expose a variety of wireless-communication and hardware interfaces which result in a large attack surface; thus, attempts to assess the degree of confidence that security needs are satisfied come with prohibited cost for automotive stakeholders and OEMs. SAFERtec project will leverage a highly-skilled consortium to first model the varying exposure of a prototype connected vehicle system to numerous threats appearing under two generic instances of the increasingly pervasive V2I setting. One relates to road-side unit communication while the other involves the interaction with cloud application and passengers' smart devices. Then, adopting a systematic vertical approach SAFERtec will obtain an in-depth look of the possible vulnerabilities performing penetration-testing on individual hardware components and upper-layer V2I applications. Considering the available security mechanisms a third party provider already applies to each module, SAFERtec will determine a corresponding protection profile as a summary of the identified risks. An innovative framework appropriately designed for unified and thus, cost-effective use across all modules will employ statistical tools and security metrics to quantify the involved security assurance levels and also feed the incomplete automotive standards. Research on dependability methods will then allow the framework's transition from individual modules to the connected vehicle system. All above results will be incorporated and made available through an open-access toolkit that will pave the way towards the cost-effective identification of security assurance levels for connected vehicle systems.

Keywords: standardized security assurance levels,connected vehicle systems,vehicular to infrastructure communication,threat analysis and attack modeling,risk level calculation,assurance framework toolkit
Multi-functionalization of hydroxyapatite for restoration and preventive conservation of marble artworks (HAP4MARBLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

The HAP4MARBLE Project is aimed at developing a new multi-functional treatment for conservation of marble artworks in Cultural Heritage (CH) and validating it in the field. Marble has been widely used in architecture and sculpture since antiquity, but it is subject to several weathering processes, predicted to be worsened by future climate change. Because not fully satisfying treatment currently exists against these weathering processes, the project will be aimed at multi-functionalizing a recently proposed biomimetic treatment based on hydroxyapatite (HAP), to make it able to tackle all the main marble degradation processes (sugaring, soiling, dissolution and bowing). This target requires a multi-disciplinary reserach activity, combining materials science, biomaterials, micro-mechanics, petrophysics and CH conservation. Such an approach will be possible by merging competences and laboratory facilities of the 3 involved Organizations: Princeton University (outgoing phase, supervisor Prof. G.W. Scherer and co-supervisor Prof. W.O. Soboyejo, world-renowned experts in materials science and micro-mechanics, respectively), the University of Göttingen (secondment, supervisor Prof. S. Siegesmund, international expert in marble deterioration) and the University of Bologna (return phase, supervisor Dr. E. Franzoni and co-supervisor Prof. N. Roveri, international experts in materials for CH conservation and HAP for bio-medical applications, respectively). Under the guidance of these experts, the Experienced Researcher (ER) will receive high-level training-through-research and will considerably deepen and diversify his knowledge, by also attending academic and training courses, thus developing a multi-disciplinary expertise. This new expertise and the publication of research results in high-level journals will enable the ER to achieve a fundamental advancement towards the fulfilment of his career development objective, which is to become a tenured researcher in EU academia.

Keywords: hydroxyapatite,marble,stone,building materials,cultural heritage,inorganic consolidants,sugaring,soiling,dissolution,bowing,self cleaning,thermal behaviour,field testing
InvisiblesPlus (InvisiblesPlus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Spain,Spain,India,Germany,Spain,Italy,Iran, Islamic Republic of,Egypt,Switzerland,Switzerland,China,Korea, Republic of,Colombia,France,United States,United Kingdom,United Kingdom,Japan,Costa Rica,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 2322000.0
EU funding (EUR): 2070000.0
Participants: 27
Project status: CLOSED

NEUTRINOS (Ns) and DARK MATTER (DM) are the most abundant particles in the universe. Their couplings to ordinary matter are so tenuous that they remained undiscovered -invisible- until very recently. N masses and DM constitute the first evidence ever of physics beyond the Standard Model of particle physics. The path to build the New Standard Model must confront the fundamental nature of the particles in the invisible sector at large. Furthermore, for each particle there is a mirror image with identical mass and opposite charge(s): its antiparticle. The laws of physics are almost particle-antiparticle symmetric: an asymmetry in Ns and/or DM properties may be the required seed that explains why the universe is made of matter and not antimatter, i.e. how come we are here, a fact unexplained by standard physics. In turn, the unnaturally symmetric behavior of strong interactions points to a new particle, the axion, a superb dark matter candidate. Very timely, an ambitious international experimental search has been launched on Ns, axions, other DM and Higgs physics with major breakthroughs expected soon. InvisiblesPlus will be the first transnational program addressing the N and DM properties at large, their interfaces, and in addition the connections of their particle/antiparticle asymmetries with those of the visible universe. It will also complement, continue and specially extend to a new qualitative realm the knowledge sharing and long-term collaboration of the well-established ITN Invisibles. InvisiblesPlus is ideally suited to the task: i) World leadership in all relevant areas; ii) Multidisciplinarity; iii) Key theorists and experimentalists; iv) XENON, Fermilab, CERN, SuperKamiokande and ADMX participate; iv) Innovative virtual institute; v) Top quality expertise from emerging countries; vi) Outstanding outreach, vii) Excellent junior/senior ratio in secondments; viii) Optimal in gender balance with over 50% female scientists in charge, plus the coordinator.

Keywords: neutrinos,dark matter,phenomenology
Modulating and Profiling Receptor Tyrosine Kinase S-palmitoylation in Breast Cancer (RTKPalm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Breast cancer is one of the most diagnosed cancers and the leading cause of cancer death in women worldwide. Breast cancer cells need activated receptor tyrosine kinases (RTKs) to invade, proliferate, and metastasize. Increased activity and overexpression of RTKs is associated with poor prognosis for breast cancer patients. Therefore, multiple RTKs have emerged as attractive therapeutic targets. However, resistance to therapies is a persistent problem for the development of therapeutics targeting RTKs. New and innovative approaches to effectively target these receptors are required. Recently S-palmitoylation has been identified as an important post-translational modification that regulates signal transduction, protein trafficking and degradation of specific RTKs in breast cancer. The substrate scope, role, extent of dysregulation and the enzymes responsible for the S-palmitoylation of specific substrates in breast cancer is largely unknown. In this context, the aim of the proposed project is to implement novel chemical biological tools and methods, to gain insight in the extent, regulation and role of S-palmitoylation of RTKs in breast cancer. This insight will facilitate the identification of new approaches to therapeutically target RTKs in breast cancer.

Keywords: s palmitoylation,postt ranslational modification,receptor tyrosine kinase,chemoproteomics,cellular genetics,organic synthesis,cancer biology