Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Driving the functional characterization of intrinsically disordered proteins (IDPfun)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Argentina,Germany,Italy,Belgium,Hungary
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1291500.0
EU funding (EUR): 1291500.0
Participants: 8
Project status: SIGNED

Intrinsically disordered proteins (IDPs), characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. However, functional knowledge for IDPs remains very limited. IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics.

Keywords: intrinsic disorder in proteins,databases,prediction,ontology,protein structure
Patroller monocytes as modulators of diabetic retinopathy (PAMpeR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-16
End date: 2020-05-15
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that its natural history could incorporate a phase of vascular repair, active after short duration of diabetes and eventually losing efficacy over time. “Patroller” monocytes, a discrete subpopulation of circulating monocytes, patrol healthy vessels by “crawling” on the endothelium at a speed that is order of magnitude lower than rolling, and at variance with the "classic" monocyte subset produce preferentially housekeeping and trophic factors rather than inflammatory cytokines. Our preliminary data strongly support a role of patrollers, in protecting and repairing retinal vessels in diabetes; suggest that the beneficial activities are delivered during leukostasis; and indicate that 5 months of diabetes duration activates a healing/protective transcriptional program in patrollers. I seek to learn whether the biosynthetic profile of patrollers changes in relation to increasing duration of diabetes and evolving retinal vascular damage; and, most importantly, I seek to bring the study of patrollers to clinical investigation. The Objectives are to: 1. Learn if circulating patrollers adapt their biosynthetic profile to different diabetes duration (3 and 9 months) and to the evolving vascular damage 2. Bring the project to clinical applicability by start setting up a human study that aims to compare and contrast the number of circulating patrollers, as well as selected biosynthetic and functional characteristics of these cells, in T1DM patients with no DR after 4-8 years of DM, in T1DM patients with initial nonproliferative DR, and in healthy control subjects. The expectation is to capture from endogenous systems the types of molecular actions that protect the vessels in early diabetes; and thus be enabled to mimic, complement, or leverage

Keywords: diabetes,diabetic microvascular disease,diabetic retinopathy,vascular repair,patroller monocytes
First-Principles Spectroscopies in Realistic Electrochemical Environments (SPECTROCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Electrocatalysis will play a central role in achieving the goal of a clean-energy cycle that goes from energy harvesting to storage and delivery. Challenges abound, but many efforts are taking place in the experimental and computational communities. We believe that in order to unravel the elementary steps of electrocatalytic reactions a unique and powerful drive will come from the development of computational techniques able to predict in-operando spectroscopic data. In fact, experimental spectroscopic techniques can offer exquisitely precise data, that nevertheless requires accurate, predictive computational models to be interpreted and translated into an atomistic mechanism. This proposal will be dedicated to the development of first-principles modelling of realistic electrochemical environments, and to the calculation of in-operando computational spectra. In particular, during this fellowship I will: (i) apply novel strategies to account for the presence of the solvent, the electrolyte and the electrode potential in quantum mechanical simulations; (ii) implement computational approaches that will enable the accurate prediction and interpretation of infrared- and X-ray-based spectroscopies; (iii) investigate the carbon dioxide reduction on model copper catalysts, advancing the current understanding of this relevant electrochemical process. This Marie Skłodowska-Curie fellowship will allow me to work in a group that is at the forefront of computational materials science and materials design, and in tight partnership with world class experimental efforts. This proposal entails numerous measures that will allow me to enlarge my collaboration network and develop new interdisciplinary skills, boosting in the process my career as independent researcher.

Keywords: first principles simulations,computational electrochemistry,density functional theory,carbon dioxide reduction,in operando spectroscopies
Visually guided grasping and its effects on visual representations (VisualGrasping)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-02
End date: 2020-07-02
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

I ask how vision guides grasping, and conversely, how learning to grasp objects constrains visual processing. Grasping an object feels effortless, yet the computations underlying grasp planning are nontrivial and there is an extensive literature describing the multifaceted features of visually guided grasping. I aim to bind this fragmented body of knowledge into a unified framework for understanding how humans visually select grasps. To do so I will use motion-tracking hardware (already in place at the University of Giessen) to measure and model human grasping patterns to 3D objects. I will rely on Dr. Fleming’s unique expertise with physical simulation to simulate human grasping with objects varying in shape and material. Joining behavioral measurements with computer simulations will provide a powerful data- and theory-driven approach to fully map out the space of human grasping behavior. The complementary goal of this proposal is to understand how grasping constrains visual processing of object shape and material. I plan to tackle this goal by building a computational model of visual processing for grasp planning. Both Dr. Fleming and I have previous experience with computational modelling of visual function. I will exploit powerful machine learning techniques to infer what kinds of visual representations are necessary for grasp planning. I will train Deep Neural Nets (for which the hardware and software is already in place and in use by the Fleming lab) using extensive physics simulations. Dissecting the learned network architecture and comparing the network’s performance to human behavior will tell us what information about shapes, material, and objects the human visual system encodes to plan motor actions. In short, with this research I aim to determine how processing within the human visual system is shaped by and guides hand motor action.

Keywords: visual perception,visual representations of shape and material,perception and action,grasping,deep learning
From the Expression of Disagreeement to New Foundations for Expressivist Semantics (EXPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1499750.0
Participants: 1
Project status: SIGNED

Disagreement is a pervasive feature of human life, which finds linguistic expression in the speech-act of rejection. If you assert that Amsterdam is in Belgium, I can express my dissent by responding 'No', thereby rejecting your assertion. In the study of human language, assertion has taken centre stage and the investigation of rejection traditionally regarded as a chapter in the study of assertion. Thus, the orthodox treatment of rejection equates it with negative assertion, so that rejecting that Amsterdam is in Belgium is tantamount to asserting that Amsterdam is not in Belgium. However, recent theories of truth have employed a notion of rejection not reducible to negative assertion. Moreover, linguistic evidence shows that rejections and negative assertions have different functions in discourse. So what is rejection? And how does it behave? The EXPRESS project will articulate a full-fledged theory of rejection as a speech-act not reducible to negative assertion. This theory will be incorporated into extant models of conversation and used to develop a novel logic of rejection faithful to the linguistic phenomena. The basic logical framework is that of a calculus containing formulae accompanied by signs for assertion and rejection. This bilateral framework will be modified to accommodate both weak and strong forms of rejection and extended into a unified multilateral framework capable of also handling weak forms of assertion. The theory and logical framework developed will be used to establish a novel approach to expressivist semantics which will be applied to the case of negation and epistemic modals. This approach will lead to distinctive hypotheses about language evolution which will be tested using computational methods. Based at the ILLC and advised by a board of researchers from Europe and the US, EXPRESS will deliver momentous advances in speech-act theory, its logic and semantics.

Keywords: rejection,disagreement,multilateral logic,weak assertion,epistemic modality
Europe at War in Post-war Europe. Performing Greek Tragedies, Comedies and European Identity. (EWPWE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

This project will examine the multiple ways in which contemporary western European theatre directors (in the UK, Germany, France, Belgium and Switzerland) have staged and continue to stage war with the help of ancient Greek dramatic scripts from the WW2 onwards. I will argue that such performances question and try to understand European identity. The three strands of this interdisciplinary project (in between Classical Reception Studies and Theatre Studies and mixing practice and theory) will cover past, present and prospective dramatic approaches of this question: 1/ academic research (archives, libraries, interviews) to analyse past performances; 2/ observation of contemporary productions in rehearsals; 3/ creative labs with students from Oxford, Paris and Liège to highlight how young Europeans are dealing with those materials. This will allow to propose a history of war on stage in post-war Europe, told through productions of ancient plays that seek, sometimes consciously indeed, to build a distinctly European identity. The fellowship will take place at the APGRD (Archive of Performances of Greek and Roman Drama, Faculty of Classics, UOXF) that is the best environment to manage such a project given its world-class database and archive of performances of Greek and Roman Drama that I will use and contribute to. This indisciplinary project will grant me the opportunity to work with some of the best researchers in Classical Reception Studies in the world (particularly with my supervisor Fiona Macintosh), strenghtening my academic network. I will improve my skills in this field and also in general European research management to become a mature researcher in Classical Reception Studies (since I have a PhD in Theatre Studies). Moreover, since I already have an extended experienc as a stage-director, this research-as-creation project will bridge my academic and artistic carreers and put me at the forefront of Theatre Studies.

Keywords: contemporary performances,theatre studies,classical reception,research as practice,greek tragedy,greek comedy,european identity,france,germany,belgium,switzerland
Cohomology and Singularities (CohoSing)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 1466124.0
EU funding (EUR): 1466124.0
Participants: 1
Project status: SIGNED

The singularities of algebraic varieties and, more generally, Noetherian schemes, tend to be reflected in the structural properties of cohomology. The goal of the project is to study this interplay, with a particular focus on positive and mixed characteristic---arithmetic settings in which the recently developed perfectoid techniques are especially relevant. The project highlights several interrelated conjectures, for instance, purity for flat cohomology, that would further our understanding of basic properties of Noetherian schemes. It proposes to develop the aforementioned interplay further by searching for invariants of singularities in cohomology.

Keywords: cohomology,perfectoid spaces,purity,resolution of singularities,weil conjectures
Advanced TeChnologies and PlatfoRm fOr Smarter ASsisted LivING (ACROSSING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Spain,Ireland,Germany,Italy,Spain,Spain,Austria,Switzerland,Belgium,Sweden,China,Greece,Greece,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3759345.47
EU funding (EUR): 3759345.4699999997
Participants: 28
Project status: CLOSED

Smart Home (SH) provides a promising approach to assisted living for the ageing population. Yet it still remains a challenge to develop and deploy such solutions in a large scale due to the lack of an easy-to-use technology infrastructure and application exemplars. This problem arises from the nature of the SH field: multidisciplinary, diverse in its applications, and with multiple stakeholders. Whilst a one-size-fits-all technology infrastructure seems unlikely, alternatives are still missing. In addition, an effective approach to cross-discipline, cross-sector understanding for best practices has so far not been seen. ACROSSING addresses this problem by implementing a multidisciplinary cross-sector pan-European training network to knock down barriers between disciplines and sectors and providing the ESRs with a broad training experience. ACROSSING develops 15 topically complementary research projects covering four core research themes, and four main application categories. By multidisciplinary collaborations and cross-sector interactions, the ESRs will develop flexible, interoperable underlying technologies which are then applied to and evaluated in multiple real application scenarios, leading to four specialised technology infrastructures and four best-practice application demonstrators. ACROSSING also deliver comprehensive blended training by combining campus-based and industrial practice training, and perspectives on personal development and social issues by well-established researchers and practitioners from academic, industry and user organisations. Whilst the scientific focus is to challenge the traditional way of SH research to develop advanced technologies and platforms, the training will train ESRs to establish links between research, real-world problems, innovation and personal career. ACROSSING will share software and datasets using open source technologies, and promote findings and impact through a number of measures, e.g. online, outreach events.

Keywords: smart home,ambient assisted living,technology infrastructure,open platform,sensing,context inference,behaviour analysis,human system interaction,service architecture
Self-organisation of microbial soil organic matter turnover (SomSOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 1896129.0
EU funding (EUR): 1896129.0
Participants: 1
Project status: SIGNED

Microbial turnover of soil organic matter (SOM) is key for the terrestrial carbon (C) cycle. Its underlying mechanisms, however, are not fully understood. The role of soil microbes for organic matter turnover has so far been studied mainly from the point of view of microbial physiology, stoichiometry or community composition. I propose to shed new light on it from the perspective of complex systems science. Microbial decomposition of organic matter requires the concerted action of functionally different microbes interacting with each other in a spatially structured environment. From complex systems theory, it is known that interactions among individuals at the microscale can lead to an ‘emergent’ system behavior, or ‘self-organisation’, at the macroscale, which adds a new quality to the system that cannot be derived from the traits of the interacting agents. Importantly, if microbial decomposer systems are self-organised, they may behave in a different way as currently assumed, especially under changing environmental conditions. The aim of this project is thus to investigate i) if microbial decomposition of organic matter is driven by emergent behaviour, and ii) what consequences this has for soil C and nitrogen cycling. Combining state-of-the-art methods from soil biogeochemistry, microbial ecology, and complex systems science I will • Investigate mechanisms of spatial self-organization of microbial decomposer communities by linking microscale observations from experimental microcosms to mathematical, individual-based modelling, • Elucidate microbial interaction networks across the soil’s microarchitecture by linking microbial community composition, process rates and chemical composition of spatially explicit soil micro-units at an unprecedented small and pertinent scale. • Explore fundamental patterns of self-organisation by applying the framework of complex systems science to high-resolution spatial and temporal data of soil microstructure and process rates.

Keywords: soil,soil organic matter turnover,terrestrial carbon cycle,self organisation,emergent properties,complex systems,microbial interaction networks