Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A structural and functional understanding Influenza virus mRNA production in the context of the transcriptionally functional ribonucleoprotein (RNP) particle. (Influenza RNP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Influenza is a major public health burden, with seasonal outbreaks contributing significantly to mortality worldwide, and the emergence of pandemic strains remaining an ever-present threat. Influenza drug and vaccine conception efforts are aided by a thorough understanding of its molecular biology. A key aspect of the influenza lifecycle is the production of capped and poly-adenylated messenger RNA by the heterotrimeric influenza polymerase (FluPol). Ground-breaking work performed by the Cusack lab, has described with residue-resolution detail, the FluPol structures that form during transcription of short, non-nucleoprotein (NP) bound viral RNAs (vRNAs). However, influenza transcription in vivo occurs within the ribonucleoprotein (RNP) particle and does not utilise naked genome segments. The viral RNP (vRNP) is a super-helical complex composed FluPol bound at the conserved 3′ and 5′ ends of a vRNA, which is coated with NP. The current low-resolution structures provide little information about the molecular details of vRNP function, particularly, how NPs interact with FluPol and the vRNA template. Via an inter-disciplinary approach, I will utilise cryo-electron microscopy methods, transcription assays and single-molecule fluorescence, to obtain the first high resolution structure of a dynamic influenza vRNP, with a particular focus on the spatial organisation of NPs relative to FluPol. In addition to this work facilitating future influenza drug research, it will provide a basis to investigate the vRNP during other lifecycle stages and act as proof-of-principle for study of other viral protein-RNA complexes, such as those from corona-, arena- and bunyaviruses. Work will be performed in the groups of Stephen Cusack and Olivier Duss based at EMBL Grenoble and Heidelberg, respectively. Here, I will have access to world-leading facilities and training opportunities, supporting my growth as an independent researcher and an expert in RNA virus structural biology.

Keywords: transcription,ribonucleoprotein,influenza virus,cryo electron microscopy,single molecule fluorescence
Boosting the scientific excellence and innovation capacity in digital holographic microscopy of the Institute of Applied Physics of the Academy of Sciences of Moldova (HOLO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Finland,Moldova, Republic of,Luxembourg
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999926.25
EU funding (EUR): 999926.25
Participants: 5
Project status: CLOSED

The overall aim of the HOLO project is to boost the scientific excellence and innovation capacity in digital holographic microscopy of the Institute of Applied Physics of the Academy of Sciences of Moldova (IAP-ASM) by creating a network with the high-quality Twinning partners: Universität Stuttgart (USTUTT), Tampere University of Technology (TUT) and Intelligentsia Consultants (Intelligentsia). To achieve this aim, the 3 year project will build upon the existing strong research and innovation base of IAP-ASM and its Twinning partners. To boost their scientific excellence and innovation capacity in digital holographic microscopy, the partners will implement a science and innovation strategy focused on two sub-topics: 1. Design and optimization of diffractive optical elements (DOE) to improve digital holographic microscopy (DHM), and 2. Development of advanced image processing algorithms for digital holographic microscopy (DHM) using diffractive optical elements (DOE) The science and innovation strategy takes into account the recent SWOT analysis of IAP-ASM and has the following objectives: • Objective 1: Strengthen IAP-ASM’s research excellence in DHM • Objective 2: Enhance the research and innovation capacity of IAP-ASM and the Twinning partners • Objective 3: Raise the research profile of IAP-ASM and the Twinning Partners • Objective 4: Contribute to the research and innovation priorities of Moldova • Objective 5: Support research and innovation on a European level In order to achieve these objectives, the consortium partners will implement a comprehensive set of measures via the project’s work packages: • Short term staff exchanges (WP1); • Training workshops, conferences and summer schools (WP2); • Dissemination and outreach (WP3).

Keywords: digital holographic microscopy,diffractive optical elements,image processing algorithms,sparse phase and amplitude reconstruction
The Inflammasome: a novel therapeutic target for the treatment of Hypoxic Brain Injury in Neonates (OxyBaby)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

Following 4.5 years abroad I hope to work as a MSCA Fellow to tackle the issue of deleterious neuroinflammation following hypoxic injury in newborns. Hypoxic Ischemic Encephalopathy (HIE) describes brain injury that occurs when an infant’s brain does not receive enough oxygen & blood. Approximately 15-25% of patients die, 1 in 4 develop severe and permanent neurological disorders including, Cerebral Palsy & later-life Epilepsy. There are currently no successful treatment options & HIE has withstood attempts to improve outcome. A critical immune complex, the inflammasome was discovered in 2002 that senses ‘danger’ & processes potent inflammatory cytokines to bioactive forms. I have generated novel data demonstrating a role for the inflammasome & specifically targeting it for treatment of hypoxic brain injury. This study advances this by assessing the exact contribution of its activity on a cellular level & temporally targeting the complex as a novel treatment. I will employ established preclinical models of hypoxic brain injury, advanced imaging techniques (2- photon) & novel small molecule inhibitors of the complex. I will work at the Royal College of Surgeons in Ireland (RCSI) with supervisor Prof David Henshall, Director of the FutureNeuro Centre, a multi-institutional national centre for chronic & rare neurological disease research. Ultimately, our proposal will aid design & improvement of current clinical care strategies for infant patients with HIE. I will work with top neuroscientists within FutureNeuro & Europe (Prof Mallard, Sweden), the leading inflammasome company, Inflazome & its CSO Prof O’ Neill and Neonatologists including Prof Murray (Cork, Ireland). My collaboration with these leaders across multiple sectors will expand my competencies/transferable skills & allow advanced multidisciplinary training from experts. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

Keywords: inflammasome,innate immunity,hypoxic ischemic encephalopathy hie,small molecule inhibitors
Cetacean Use of Representational Acoustic Signals (CURAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-25
End date: 2017-08-24
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project will determine if dolphins possess representational understanding of individual-specific signature whistles (SW). Dolphin SWs are a created and learned social signal and are thought to function similar to human names. We will examine parallels between dolphin use of SW and human use of acoustic labels which will give us an understanding of representational signalling systems outside of human communication. Research from the host organization has demonstrated that dolphins use innovated and learned contours to address specific individuals, and research conducted by the fellowship applicant has shown that dolphins maintain the memory of these contours for over 20 years. The next step for both programs is to determine if SWs are representational (i.e. do the SWs elicit a mental image of the caller in the minds of the receiver). Establishing this would show that SWs do function similarly to human names and that long-term memory for these whistles is tantamount to long-term memory for social partners. Furthermore, demonstrating a representational relationship between a signaller and signal in SWs would provide a true understanding of mental representations elicited by signals in a non-humans animal species, something that is extremely difficult to demonstrate in animal communication. To do this, we will first assess the dolphins’ ability to identify conspecifics by gustatory recognition of excreta. Then, using the practice of cross-modal playbacks of sound and chemical cues, we will look for response differences between matches and mismatches of individual identity coded through the two modalities.

Keywords: dolphin communication,chemical signaling,cognition,referential communication,representational communication
Selective glycan recognition using molecularly imprinted liposomes (GLYCANLIPO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-03
End date: 2021-03-15
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Glycans, also referred to as carbohydrates, occur as simple or complex structures in free form or in many different kinds of glycoconjugates, which include glycoproteins, glycolipids and proteoglycans. Glycans carry information in biological systems that make them an important source of biomarkers for wide range of diseases, including neurodegenerative diseases, hereditary disorders, immune deficiencies, cardiovascular diseases and many types of cancers. While recognition of glycans by other molecules with high affinity and exquisite specificity is at the heart of the early and accurate detection of such diseases, selective glycan recognition remains a daunting task due to their inherent diversity and complexity. The aim of this innovative Fellowship is to use concepts and tools from lipid membrane biophysics and molecular imprinting to provide synthetic recognition platforms with high sensitivity and specificity for glycans. For the first time, we will exploit (i) lateral mobility of polymerizable lipids functionalized with carbohydrate receptors in a fluid bilayer and, (ii) multivalent interactions between the target glycan and multiple carbohydrate receptors to produce liposome surfaces with high affinity binding sites that can sharply discriminate between different glycans, including tumour-associated glycans that contain sialylation, fucosylation and biantennary structures. Owing to great clinical importance of cancer-associated glycans for early detection and targeted therapies, the work will have significant economic and societal impacts, assisting the meeting of EU Directive requirements whilst providing an exceptional training opportunity for the ER.

Keywords: liposomes,glycan sensing,molecular imprinting,polymerizable lipids,lipid bilayer,colorimetric assays,polydiacetylene,single liposome analysis
Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways (FitteR-CATABOLIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-03-31
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Since a few decades, human patients who suffer from severe illnesses or multiple trauma, conditions that were previously lethal, are being treated in intensive care units (ICUs). Modern intensive care medicine bridges patients from life-threatening conditions to recovery with use of mechanical devices, vasoactive drugs and powerful anti-microbial agents. By postponing death, a new unnatural condition, intensive-care-dependent prolonged (>1 week) critical illness, has been created. About 25% of ICU patients today require prolonged intensive care, sometimes for weeks or months, and these patients are at high risk of death while consuming 75% of resources. Although the primary insult was adequately dealt with, many long-stay patients typically suffer from hypercatabolism, ICU-acquired brain dysfunction and polyneuropathy/myopathy leading to severe muscle weakness, further increasing the risk of late death. As hypercatabolism was considered the culprit, several anabolic interventions were tested, but these showed harm instead of benefit. We previously showed that fasting early during illness is superior to forceful feeding, pointing to certain benefits of catabolic responses. In healthy humans, fasting activates catabolism to provide substrates essential to protect and maintain brain and muscle function. This proposal aims to investigate whether evolutionary conserved catabolic fasting pathways, specifically lipolysis and ketogenesis, can be exploited in the search for prevention of brain dysfunction and muscle weakness in long-stay ICU patients, with the goal to identify a new metabolic intervention to enhance their recovery. The project builds further on our experience with bi-directional translational research - using human material whenever possible and a validated mouse model of sepsis-induced critical illness for objectives that cannot be addressed in patients - and aims to close the loop, from a novel concept to a large randomized controlled trial in patients.

Keywords: ketone,fatty acid,ppar,muscle,neuron,astrocyte,sepsis,fasting,fasting mimicking,ketogenic diet
INNOVATION MANAGEMENT SERVICE SUPPORT OF EAST MARMARA NETWORK (INNOV-EM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye,Türkiye,Türkiye
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 100125.0
EU funding (EUR): 100125.0
Participants: 6
Project status: CLOSED

INNOV-EM Consortium composed of six partners with different type of structures like public, semi-public and private institutions and their different internal procedure struggled to achieve its targets by performing activities as projected in work plan.KOSGEB Bursa , ABİGEM DM, ULUTEK and KOU Techno park are main partners while BCCI and ECI are only supporting inactive partners of the project proposed. The project aimed to offer integrated SME services of enhancing capacity of managing innovation processes and 'key account management' of successful SME Instrument applicants .Under this project mentoring and coaching services offered to SME’s. Horizon2020 (H2020) programmes and the project aims to assist the SMEs to cope with challenges of competitiveness, Related to the Key Account Management for beneficiaries of the SME Instrument (KAM) services only two partners proposed targets which are KOU Technopark and ULUTEK and since there are SME Instrument beneficiaries could be determined in the region, the consortium would like to provide KAM services for the project. Consortium focused on raising the number of companies that will be able to apply for the SME Instrument in the region via services enhancing innovation management capacities of SMEs as projected in 2020-2021 period.In the second period of the project, the SMEs which are defined as suitable for innovation management service support diagnosed with the IMP³rove. The SMEs’ gaps, weak points and bottleneck identified with the IMP³rove diagnostic tool and jointly agreed action plan will be prepared for the innovative SMEs developing their innovation management capacity.

Keywords: innovation,sme instrument
Image Enhancement & Page Standardisation Solution for Error-free Printing and 35% Ink Saving (ColorBOX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As Pico Technology & Solutions we are a Value-Added Distributor based in Reggio Emilia distributing technology, software and IT solutions since 1987. Amongst our clients are Apple Premium Resellers, Corporate Resellers, Value Added Resellers and Systems Integrators. We have developed a solution (ColorBOX) under the Publishing, Prepress and printing business unit. We are focussing on the prepress colour management segment of the printing industry set to grow from €71.7B in 2017 to €131.4B in 2025. ColorBOX is an all-in-one solution that automatically optimizes the printing properties of PDF and image files in the printing workflow. It also enhances the images according to International Color Consortium (ICC) standards and colour profiles for typical prepress workflow. Target user include digital printers, commercial printers, WIDE Format Digital Printers, newspapers as well as editorial companies. Our solution offers the following benefits: * Reduction in raw material needs [35% ink savings, 0% printing error] * 90% Reduction in disposal costs * Reduction in operational costs [50% faster printing time, 10% reduction personnel cost, 30min starting time] * Easier compliance to industry standards and regulations [ICC optimized image colour profile] Having invested €0.5M to produce a technically viable prototype, we are progressing our development to a commercial version. We will undertake a Phase 1 project to finalise functionality and specifications for the dashboard, the specific end-user demographics as well as search for development and commercial partners for technical and commercial success. In addition to developing a detailed Intellectual Property strategy and dissemination plan, we will also outline the activities and timelines we will adhere in the Phase 2 project towards a 2019 market launch. We anticipate that ColorBOX will yield a turnover of €17.2M and cumulative profit of €7.5M by the 5th year on the market.

Keywords: printing,prepress,workflow,image,colour management,colour,soft proofing,image enhancement,pdf optimisation,page standardisation
Automatic System Testing (AST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Verifying the correctness of software systems requires extensive and expensive testing sessions. While there are tools and methodologies to efficiently address unit and integration testing, system testing is still largely the result of manual effort. Testing software applications at the system level requires executing the applications through their interfaces to verify the correctness of their functionalities and stimulate all their layers and components. Automating just part of this process can dramatically improve the effectiveness of verification activities and significantly reduce development costs, relevantly alleviating developers from their verification effort. This project addresses the development of a pre-commercial tool that has the unique capability of efficiently and automatically generating semantically-relevant system test cases equipped with functional oracles. This capability derives from the AUGUSTO technique, which is an outcome of the Learn ERC project. The idea behind Augusto is to exploit the common-sense knowledge, that is, the background knowledge that every computer user has and that normally lets her/him use software applications without the need of accessing any documentation or manual. Once this knowledge is represented abstractly and then embedded in AUGUSTO, the technique can automatically adapt its definition to the software under test every time a program is tested. This development work will be performed jointly with A company that produces and markets testing tools.

Keywords: software testing