Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deep-Red/NIR Multi-Resonance Delayed Fluorescence Emitters for Efficient OLEDs (DRNIRMRDF)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Lithuania
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 158597.76
EU funding (EUR): 158597.76
Participants: 1
Project status: CLOSED

Multiple-resonance (MR) thermally activated delayed fluorescence (TADF) materials are the current research hotspot in organic light-emitting diodes (OLEDs) due to their ability to deliver remarkable color purity with full-width-at-half maximum (FWHM < 30 nm) and high efficiency. However, emission of the majority of reported MR-TADF emitters fell in the blue/green region because of their intrinsic triangulene geometry and limited scope for structural diversity, while examples of emitters addressing the other primary colors required for displays are either rarely (red) or not (Near-Infra Red (NIR)) reported. In addition, most MR-TADF OLEDs show severe efficiency roll-off and poor operational stability. Therefore, it is urgent need to make the new molecular designs for producing long-wavelength (> 600 nm) MR-TADF emitters i.e. pure-red/NIR MR-TADF emitters without compromising the emission color purity (FWHM < 25 nm) and efficiency roll-off of OLEDs. These materials are not only applicable in OLEDs, but also useful in night vision displays, sensors and information-secured displays. To this end, here we proposed two new MR-TADF emitter designs to circumvent the aforementioned drawbacks. In the first approach, we have designed linearly π-extended boron (B)/Nitrogen (N)-based polyaromatic hydrocarbon (PAHs) for shifting the emission into deep-red region. In the second approach, we have proposed a simple, yet versatile design for constructing narrowband NIR emitters. The rationality of the proposed designs were validated by the preliminary computational studies. This is a highly interdisciplinary project that covers the fields of organic synthesis, computational modelling, physical and optoelectronic characterization, OLED fabrication and testing. This proposal exploits the two-way transfer of knowledge between the host and the applicant, and the state-of-the-art facilities of the host organization.

Keywords: mr tadf narrowband emission deep red nir efficiency roll off stability oleds
STORYBOX (STORYBOX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 1981000.0
EU funding (EUR): 1981000.0
Participants: 1
Project status: SIGNED

StoryBox is a revolutionary AI-powered operating platform that unlocks the power of video content creation for corporates around the world. It eliminates the barriers for corporates to create video content as well as facilitates the integration of video solutions to help them achieve their business goals. StoryBox is an AI-driven operating platform that serves the full value chain from planning, creation, and collaboration to distribution for a variety of use cases (HR, know-how transfer, social media and corporate communications). StoryBox is Built-in enablement and compliance and brings stunning user enablement through AI-driven software for authentic video communication at scale. StoryBox is an operating system powered by the latest deep-tech technologies, to disrupt the current video content creation industry. It is currently a TRL7 Pilot system, ready for the market in 2 years.

Keywords: video content creation,hr,know how transfer,social media,corporate communications,ai driven software,
Augmented local therapy to transform the lives of gout patients (PKM-01)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Gout, a prevalent form of arthritis affecting millions globally, causes excruciatingly painful flares primarily in the lower limb joints. Current treatments, including oral Non-Steroidal Anti-Inflammatory Drugs, oral Colchicine, and glucocorticoids, offer limited efficacy and present significant side effects and safety concerns. There is an urgent need for more effective and safer therapeutic options. PK MED, a preclinical-stage biotech company, introduces PKM-01, a pioneering intra-articular colchicine product for local injection in joints, targeting gout flares. This innovative approach combines drug repurposing with advanced drug delivery systems to ensure controlled pharmacokinetics through proprietary formulations and technologies. PKM-01 is expected to revolutionize gout flare management and become a new standard in local therapy for joint diseases. It is the only solution offering rapid onset of action, significantly higher efficacy in pain reduction, and minimal systemic side effects or drug-drug interactions. PKM-01 has demonstrated remarkable results in preclinical models, achieving a local effective concentration of colchicine over 7 to 10 days while maintaining very low plasma concentrations. This project will perform the Phase 2 clinical validation of PKM-01 and accelerate its time to market for the benefit of the patients. The global burden of disease and treatment will be alleviated with a substantial reduction of healthcare costs and economic impact. Once validated in gout, PKM-01 holds promise for other indications, such as Pseudo-gout and Osteoarthritis. The projected market potential, particularly with the extension to additional indications, positions PKM-01 as a catalyst for PK MED's scale-up as a European leader in local therapies.

Keywords: gout,arthritis,preclinical,clinical,pharmacokinetics,local,targeted,therapy
Batteries reuse and direct production of high performances cathodic and anodic materials and other raw materials from batteries recycling using low cost and environmentally friendly technologies (RHINOCEROS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Spain,Germany,Belgium,Italy,France,Sweden,Norway,Türkiye,United Kingdom
Call: Sustainable, safe and efficient recycling processes (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 8943026.25
EU funding (EUR): 8943025.75
Participants: 17
Project status: SIGNED

Rhinoceros will develop, improve and demonstrate, in an industrially relevant environment, an economically and environmentally viable route for re-using, re-purposing, re-conditioning and recycling of EoL EV and stationary batteries. Rhinoceros will first develop a smart sorting and dismantling system enabling the automated classification and dismantling of LIBs and the reassembly of still working modules in new repurposed batteries for second life applications such as batteries for energy storage systems. When direct reuse and repurpose of batteries is not possible, a circular recycling route of all the materials present in LIBs (e.g., metals, graphite, fluorinated compounds and polymers, active materials) will be followed to close the materials loop. This route is based on a set of cost efficient, flexible and environmentally friendly routes targeting the pre-treatment, refining and the recovery of materials. Through product qualification by industrial end-users, Rhinoceros will demonstrate the direct production of high performances cathodic and anodic materials and other raw materials at competitive costs from battery recycling. The achievements will bring Europe to an increased independence level from foreigner manufacturers and raw materials suppliers.

Keywords: end of life batteries,electric vehicles,stationary battery,automated dismantling,repurposing,recycling
ONE HEALTH PREVENTIVE INTERVENTIONS, CITIZEN PERSPECTIVES AND COMMUNITY EMPOWERMENT INITIATIVES TO UNDERSTAND THE COMMUNITY JOURNEY TOWARDS PANDEMIC PREVENTION (PANDASIA-NOVA) (PANDASIA-NOVA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 498087.5
EU funding (EUR): 498087.5
Participants: 2
Project status: SIGNED

Pandemic prevention requires a multiple-perspective approach for understanding of potential preventive One Health interventions, including social, ecological, and economic dimensions. The overall objective of the PANDASIA-NOVA project is to expand and deepen scientific evidence on potential interventions that target zoonotic diseases in Thailand and explore their driving factors at the level of the general population but also at a decision-makers level. To reach this goal, Universidade Nova de Lisboa (NOVA) will support, collaborate and contribute to the ongoing Horizon Europe project PANDASIA in identifying and understanding those driving factors, as well as other potential One Health interventions, and include analyses of the citizen perspective along their journey. In this regard, we propose to investigate citizen behaviour from several dimensions to better understand what can determine their engagement in prevention interventions (initial stage) and later identify how the proposed interventions can affect the social and humanistic dimensions (final stage). NOVA will collaborate with and support PANDASIAs work packages on Society and Spillover Risk and Pandemic Prevention and Preparedness Literacy Intervention (3PL) building on the knowledge produced in these WPs. The project will contribute to the expected outcomes and impacts of the Hop on Facility call. NOVA will contribute to the specific objectives, outcomes and impacts of PANDASIA, specifically in relation to human and social factors impacting zoonotic spillover risk, such as human behaviours, structural drivers and barriers, and policies; and in creating and testing a critical public health measure (the 3PL) to reduce zoonotic transmission and pandemic risk. The outreach of these research actions and the collaboration with other consortium partners will mobilize expertise and excellence and improve knowledge sharing for NOVA as a widening partner.

Keywords: citizen behaviour engagement social outcomes humanistic outcomes structural equation modeling
Exploiting plasmid–bacteria interactions to fight the evolution of antimicrobial resistance (PLAS-FIGHTER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1999573.0
EU funding (EUR): 1999573.0
Participants: 1
Project status: SIGNED

The discovery of antibiotics revolutionised the fight against infectious diseases and paved the way for modern medicine. However, widespread use of antibiotics has driven rampant evolution of antimicrobial resistance (AMR) in bacteria. The main route for AMR acquisition in clinically important bacteria is the horizontal transfer of plasmids (conjugation-competent mobile genetic elements) carrying resistance genes. AMR plasmids allow bacteria to survive antibiotics, but they also entail physiological alterations in the host cell. Recent results from my group and others reveal that AMR plasmids (i) produce a shared set of physiological alterations in the bacterial host and (ii) induce changes in host antibiotic susceptibility profiles. The goal of PLAS-FIGHTER is to exploit plasmid-induced physiological effects in bacteria to develop new ecology- and evolution-informed strategies against plasmid-mediated AMR. First, we will use genome-wide CRISPRi screening technology to dissect the molecular basis and functional consequences of plasmid-induced physiological effects in clinical bacteria at an unprecedented level of resolution, revealing new specific targets in AMR plasmid-carrying cells. Second, we will perform high-throughput susceptibility assays, using inhibitors of the targets revealed in the first objective and a wide range of antibiotics in a collection of paired isogenic plasmid-carrying & plasmid-free bacterial strains of the highest clinical relevance. Crucially, we will perform experiments and test candidate treatments in a gradient of increasing ecological complexity, in terms both of community composition (from monocultures to human gut communities) and habitat structure (from in vitro lab cultures to the mouse gut). In PLAS-FIGHTER, I will build on my established expertise and pioneering results to develop a novel, multidisciplinary, ground-breaking project that will open up new research avenues towards ecology- and evolution-informed anti-AMR strategies.

Keywords: mobile genetic elements,plasmid biology
Envisioning an integrated quadruple helix and RRI framework for food system transformation and regional innovation ecosystem enhancement (VISION4FOOD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Belgium,Spain,Greece,Netherlands,Denmark,Poland,Italy,Finland
Call: Regional ecosystems of innovation to foster food system transformation (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3952416.18
EU funding (EUR): 3499019.45
Participants: 13
Project status: SIGNED

VISION4FOOD aims to enhance the sustainability and resilience of EU food systems through the development of innovative governance models that contribute to better informed decision-making processes while promoting social engagement and innovation in 5 European regions (Finland, Spain, Italy, Greece, Poland) with different innovation ecosystem maturity levels. Through the project, our regions will be supported to strengthen their role in the creation of Food Innovation Platforms (FIPs), fostering collaboration among Quadruple Helix stakeholders and facilitating the identification, and scaling of innovations for food system transformation. The methodology involves co-creating R&I strategies, emphasizing open science, and Responsible Research Innovation (RRI). Through VISION4FOOD multi-stakeholder approach and the integration of tools and services we will provide them all the necessary support for knowledge exchange, networking and priority setting in the form of an acceleration agenda tailored to each region’s priorities and needs while facilitating the transition to an innovative and inclusive food system. We will closely monitor and evaluate the performance of the governance models’ operation, providing evidence of its impacts.

Keywords: rri tools,new governance models,open innovation,cross regional knowledge transfer,awareness and empowerment,quadruple helix models,food innovation platforms,healthy and sustainable food systems
Countering Oppositional Political Extremism through Attuned Dialogue: Track, Attune, Limit. (OppAttune)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Greece,Slovenia,Portugal,Serbia,Kosovo,Iraq,Bosnia and Herzegovina,United Kingdom,France,Sweden,Germany,Austria,Malta,Türkiye,Cyprus
Call: Evolution of political extremism and its influence on contemporary social and political dialogue (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 2091735.19
EU funding (EUR): 2091735.19
Participants: 17
Project status: SIGNED

OppAttune tracks the evolution of oppositional extreme ideologies and protectionist decision-making, develops an innovative attunement model and tests a series of interventions at the national and transnational levels which limit the spread of extremism. OppAttune revitalises trust in key democratic institutions. Its actions involve an on-line I-Attune self-test interactive to build democratic capacity across diverse publics. OppAttune will create an OppAttune Summer Academy for students and researchers (2025) and an OppAttune Winter Academy for practitioners and policymakers (2026). OppAttune provides micro, meso and macro level evidence-based recommendations and strategies designed to counter the potential of extreme narratives to disrupt democratic growth. It delivers this via a multi-disciplinary consortium of 17 countries across the EU and its periphery. Democracies and the European project are under threat by extremism and lack of political and social dialogue. Existential insecurities arising out of economic and refugee-related crises have been exacerbated by Covid-19 to create re-bordering e.g., xenophobic-nationalism and re-shoring e.g., the localisation of production. Oppositional worldviews, narratives and dissensus within public debate are all vital to a functioning democracy. However destructive polarisation of oppositional us/them logic is at the core of the rise of extremist narratives. Disruptive actors polarise oppositional logic using disinformation, emotions, hot cognitions, conspiracy theories and mistrust to create new forms of direct action. This direct action is understood to many as direct democracy. This direct action cultivates unlikely coalitions creating attractive alternative on-line/off-line worlds which spread extreme narratives into the mainstream via deep rooted sociological and historical pathways. OppAttune will track, attune and limit extreme narratives to foreground EU transnational freedoms and multilateralism.

Keywords: political dialogue,extreme narratives,democracy,human rights,discursive governance,social dialogue
Theoretical Foundations of Advanced Synthesis (ADVANSYNT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2328750.0
EU funding (EUR): 2328750.0
Participants: 1
Project status: SIGNED

The rapid development of complex and safety-critical systems requires reliable verification methods. In automated synthesis, we transform a specification into a correct-by-construction system. In recent years, there have been significant advances in the algorithmic front of synthesis. Still, the integration of synthesis in industry has been slow. This project addresses two critical reasons why synthesis has been hindered. First, while verification offers designers a tool to check their designs, synthesis aims to replace manual design. Designers will give up manual design only after being convinced that the automatic process replacing it indeed generates systems of comparable quality, which current definitions of synthesis ignores. Second, designers can cope manually with simple settings. Thus, automated synthesis is needed in complex settings, which are not covered by current definitions of the problem. My overarching objective is to develop the theoretical foundations of advanced synthesis, namely the next generation of synthesis concepts and algorithms, taking into account the complex settings in which synthesis is needed and the many considerations that are abstracted in current definitions of the problem. I will formalize and study the following three aspects of advanced synthesis: (1) Quality and complexity measures: behavioral quality as well as complexity measures that refer to resources needed by the synthesized system. (2) Game-theoretic considerations: settings with components that may or may not collaborate in order to cooperatively or selfishly achieve individual and common objectives. (3) Evolving and unpredictable environments: behavioral, structural, and conceptual assumptions on the environment. The research will be based on clean mathematical foundations and will combine the above methodological contributions with advances in the theory and applications of automata on infinite objects.

Keywords: automated synthesis,automata on infinite objects,game theory,temporal logic