Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Repurposing of CAST Systems as Next-Generation Tools for Genome Engineering of Mammalian Cells (INTETOOLS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2475491.0
EU funding (EUR): 2475491.0
Participants: 1
Project status: SIGNED

Genome editing using RNA-guided CRISPR-Cas nucleases (Clustered Regularly Interspaced Short Palindromic Repeats that associate with CRISPR associated proteins) has radically altered life sciences, enabling genome manipulation in living organisms. However, their use is limited by dependence on DNA Damage Response (DDR), which restricts genome editing to dividing cells. Further, these nucleases cannot handle DNA cargos large enough to harbour regulatory DNA circuitry, thus precluding genome engineering. In INTETOOLS, I will overcome these limitations by dissecting and repurposing CRISPR Associated Transposon (CAST) systems into genome engineering tools. CASTs are naturally occurring prokaryotic protein–RNA machineries consisting of an inactive CRISPR effector complex, which associate with Tn7 family transposons to insert large DNA cargos. Knowledge of their molecular mechanisms is scarce, which prevents their practical application in genome engineering. Accordingly, in Objective 1, I will investigate the architecture of different CASTs to obtain fundamental knowledge of their RNA-guided integration. I will then use this knowledge in Objective 2, to dissect their mechanism underpinnings whereby CRISPR-Cas complexes associate with transposition complexes to insert with nucleotide accuracy DNA cargos. This will inform Objective 3, where I will design new CAST tools that will allow RNA-guided transposition in eukaryotic genomes. These revamped CASTs will be capable of inserting large DNAs with high precision, harbouring regulatory regions into eukaryotic genomes, enabling genome engineering in eukaryotes. I will test the redesigned CASTs in mammalian cell lines and at the organismal level by rescuing the eyeless mutant phenotype in Drosophila melanogaster. INTETOOLS will catalyse a conceptual leap propelling the field into a new era of genome engineering, with major biomedical and biotechnological applications especially in synthetic biology.

Keywords: gene editing,protein design,cryoem,crispr,genome engineering,protein structure
Integrating Innovations for the Protection and Restoration of European Lakes (FutureLakes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Norway,Denmark,Greece,France,Finland,Italy,Netherlands,United Kingdom,Poland
Call: European natural lakes: demonstration of integrated approaches for protection and restoration of natural lake ecosystems and their biodiversity (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 3786147.12
EU funding (EUR): 3720566.5
Participants: 11
Project status: SIGNED

The overarching objective of FutureLakes is to demonstrate innovative solutions needed to transform lake restoration, integrated into lake management. These aim to significantly improve ecological and chemical status of European lakes, restore biodiversity, recover valuable resources, enhance the services that lakes provide and make society more resilient to climate change. FutureLakes aims to deliver this through an integrated framework for lake protection and restoration that demonstrates a range of technical solutions that include innovations in Nature-based Solutions, Circular Blue Economy Solutions and Biodiversity-focused Solutions. Demonstrating integration of these solutions in operational lake management in six large European lakes (Demo Basins) which will deliver a Blueprint for lake protection and restoration. The FutureLakes Blueprint will incorporate a catalogue of innovations and guidance on the enabling environment needed to turn promising technical innovations from niche measures to become mainstream approaches in lake basin management planning. This includes demonstrating more effective and inclusive collaboration in water governance and showcasing innovations in policy implementation and green financing. FutureLakes will also develop a Roadmap for Upscaling European Lake Restoration in support of the Mission Restore our Ocean and Waters deployment and upscaling phase. Upscaling of measures across Europe will be tested through activities aimed at replicating the FutureLakes approach in three associated regions. FutureLakes will not only contribute to delivering to the three objectives of the Mission (to protect and restore freshwater ecosystems and their biodiversity; to reduce pollution; and to build a sustainable carbon-neutral and circular blue economy) but it includes specific objectives to develop the Mission’s two enablers: creating a European Lakes Digital Innovation Hub and demonstrating innovative approaches to enhancing public engagement.

Keywords: lake restoration
Ferroic Materials for Dynamic Heat Flow Control (DYNAMHEAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1495000.0
EU funding (EUR): 1495000.0
Participants: 1
Project status: SIGNED

Tackling climate change is one of the most pressing challenges of our modern society and requires researching new refrigeration and renewable energy systems. Performances of all these systems could be significantly improved if they were combined with solid-state thermal switches and diodes. Current strategies that require to nanostructure materials or to operate in the vicinity of a phase transition, lead to thermal switches or thermal diodes with low efficiencies or not suitable for applications where space is limited. Furthermore, once designed, thermal properties of these elements are set and cannot be modified. My objective is to investigate a fundamentally new mechanism to design compact and efficient thermal switches and diodes. My strategy exploits, in ferroelectric and ferroelastic oxides, the interactions between phonons and spontaneously occurring planar defects known as domain walls. Domain walls can be easily generated, moved, and oriented by application of a small voltage or a small uniaxial pressure, and interact with phonons as defects do. They are thus perfect interfaces to achieve large and reconfigurable anisotropies in thermal conductivities in controlled directions in a fast and reversible way. In this ambitious project, I develop a novel approach to demonstrate a dynamic heat flow control through (i) the reversible engineering of the density of domain walls in desired directions, and (ii) the development of advanced experimental techniques for in-operando thermal characterizations. My multidisciplinary strategy will unravel the interactions between phonons and domain walls to reach higher thermal conductivity variations, and lead to ground-breaking thermal switches and diodes. These thermal switches and diodes will be compatible with a large range of devices and have an impact in many fields critical for our transition toward a sustainable future (e.g. solid-state refrigeration, solar panels, thermoelectric devices).

Keywords: ferroelectric,domain wall,thermal diode
RCSI Gender Equality Champions for Innovative Inclusion Category 3 Submission (RCSI)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: EU prize
Destination: EU Award for Gender Equality Champions
Action type: Recognition Prize
Countries involved: Ireland
Call: Inclusive Gender Equality Champions (HORIZON-WIDERA-2024-GENDER-Prize, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

This submission outlines RCSI's application to Horizon Europe's Gender Equality Champion Award for the Inclusive Gender Equality Champions Category. RCSI established a dedicated Equality, Diversity and Inclusion Office in 2017. This application reflects the actions and achievements realised during our first Gender Equality Plan 2018 - 2023 and incorporates all five of the EU GEP thematic areas: (1) Work-life balance and organisational culture; (2) Gender balance in leadership and decision-making; (3) Gender equality in recruitment and career progression; (4) Integration of the gender dimension into research and teaching content; and (5) Measures against gender-based violence including sexual harassment.

Keywords: gender equality,intersectionality,innovative inclusiveness,higher education
Flexible Lightweight AI-Aided Receivers (FLAIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Artificial intelligence (AI) is envisioned to play a key role in future wireless technologies, with deep neural networks (DNNs) enabling digital receivers to learn to operate in challenging communication scenarios. However, wireless receiver design poses unique challenges that fundamentally differ from those encountered in traditional deep learning domains. The main challenges arise from the dynamic nature of wireless communications, which causes continual changes to the data distribution, combined with the limited power and computational resources of wireless devices. These challenges impair conventional AI based on offline trained massive DNNs. Our ambitious goal is to introduce a new form of flexible lightweight AI that is particularly tailored for wireless communications. Our approach is based on a holistically revisiting the three fundamental pillars of AI – the architecture, dictating the family of learned mappings; the training algorithm that tunes the architecture; and the data based on which learning is carried out. Accordingly, we focus on three objectives – 1) design trainable receiver architectures that are lightweight and support adaptation to rapid channel variations; 2) establish a new learning paradigm that deviates from conventional training, and is based on viewing continual learning as a dynamic system; and 3) propose techniques to accumulate online data sets that are sufficiently informative for learning purposes while being small enough not to induce notable complexity in training. This is a fundamental depart from conventional deep learning, based on highly-parameterized DNNs trained with massive data sets using lengthy learning procedures. Our preliminary data show that this paradigm shift achieves substantial performance, robustness, and complexity gains over conventional deep receivers. The project will transform how communications systems are studied, and profoundly impact a multitude of applications that rely on wireless communications.

Keywords: wireless communications,deep learning,dynamic channels,receivers
The first broad-spectrum treatment against pandemic-prone flaviviral infections: Dengue, West-Nile and Zika (ATLAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2026-08-31
Duration (months): 42.0
Total project cost (EUR): 14465988.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

WHO, governments and health institutes are urgently seeking methods to prevent future catastrophic flavivirus outbreaks affecting millions (annually >40% of the global population at risk, resulting in ~395M infections, >25,000 deaths of which mainly children, 750.000 disability-adjusted life years and >€9B direct & indirect costs). As there are no effective treatments or vaccines available, ATLAS will provide a breakthrough in broad-spectrum antivirals: the first-in-class drug to combat the global health emergency of flaviviral infections. In the ATLAS project, Protinhi will finalize clinical trial-enabling studies and pharmaceutical development and obtain proof-of-concept in humans by conducting Phase I and Phase IIa clinical trials against the most common flavivirus: dengue. This will put the company in an excellent position to attract interest from pharmaceutical companies (e.g. Gilead, J&J, MSD) for a strategic partnership for late clinical development and commercialization.

Keywords: pandemic preparedness,west nile,dengue,prophylaxis,therapeutics,drug development,peptidomimetic,outbreak management,flavivirus,antivirals,zika
Assessing and Consolidating Recent Advances on Freshwater Ecosystem Restoration (EcoAdvance)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Coordination and support actions
Countries involved: France,Hungary,Czechia,Austria,Israel
Call: Assessing and consolidating recent scientific advances on freshwater ecosystem restoration. (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-08-01
End date: 2025-07-31
Duration (months): 36.0
Total project cost (EUR): 499995.0
EU funding (EUR): 499995.0
Participants: 5
Project status: SIGNED

The alarming state of freshwater ecosystems today: Freshwater ecosystems degraded due to barriers / other morphological changes; loss of wetlands / floodplains; over abstraction of surface / ground waters; land management that reduces infiltration / generates pollution! Millions of euros and hours in ecosystem restoration works have made improvements, yet not stemmed the tide of biodiversity loss. The overwhelming complexity and diversity of approaches, the sheer mass of sometimes contradictory data, the frighteningly heavy toll that failures take on public perception of the potential for Europe to succeed, the lack of media understanding of the challenges and our potential to deal with them – all of these demand a multi-pronged, country-by country campaign to consolidate recent scientific advances and innovations and to train the media to communicate them and the evidence that Europe can indeed halt biodiversity loss. EcoAdvance will co-create, through broad consultations and crowdsourcing, a user-friendly Prone2Success Checklist cataloguing the climate, environmental, economic, scientific, technological and human factors, country by country, that can make a difference and how to duplicate them. EcoAdvance will consolidate recent scientific advances, drive media messaging and put a persuasive human face on freshwater ecosystem restoration successes - all from the perspectives of the people who did them, pursued, supported, tested, modified, demonstrated or evaluated them. By identifying and showcasing successful people, science and solutions that are “bending the curve”, EcoAdvance will bring guidance from personal journeys to support current leaders, scientists and decisionmakers who face some of the same challenges and dilemmas the successful have already navigated, as they try to figure out: Will this work? Is it worth the money, time and effort? Is it the right thing to do for our community and our circumstances?

Keywords: showcasing successful solutions
OBSERVING AND MAPPING MARINE ECOSYSTEMS – NEXT GENERATION TOOLS (OBAMA-NEXT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Denmark,Norway,Spain,Finland,Germany,Italy,Netherlands,Estonia,Romania,Bulgaria,Portugal,United Kingdom,Greece,France,Belgium
Call: Observing and mapping biodiversity and ecosystems, with particular focus on coastal and marine ecosystems (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 8612070.5
EU funding (EUR): 8612068.5
Participants: 23
Project status: SIGNED

OBAMA-NEXT aims to develop a toolbox for generating accurate, precise and relevant information characterising marine ecosystems and their biodiversity. This will be achieved by integrating new/emerging technologies, including remote sensing, eDNA, optical instruments and citizen science, with existing marine monitoring techniques for improving our capacity to describe ecosystem function and biodiversity with higher spatial and temporal resolution. The project will contribute to shaping next generation monitoring programs and defining Essential Ocean/Biodiversity Variables (EOVs/EBVs). Stakeholders will be involved from the onset of the project to identify products needed in an iterative co-creating and specification process. These specifications will guide the application of algorithms, including advanced statistical analyses and artificial intelligence, which combine and translate different data sources into information products (i.e., maps and indicators) to fulfil stakeholders’ needs. Routines for visualisation and methods for uncertainty assessment are also important components of the toolbox development. The toolbox will be evaluated and improved based on 12 selected Learning Sites (LS), representing diverse ecosystems and data sources within the four European regional seas. The applicability of the information products, compiled with the toolbox on LS data, will be evaluated as input to models for predicting biodiversity and as support for environmental and biodiversity policies. The project will also assess the usefulness of the products with respect to the EU objective of designating an ecologically coherent MPA network and the applicability of C-burial rates in angiosperm habitats for carbon offsetting and Nationally Determined Contributions. OBAMA-NEXT will strengthen Europe’s capability in acquiring and utilising biological ocean observations for better management of marine resources through strong public outreach and active stakeholder communication.

Keywords: biodiversity invasive species monitoring eov ebv edna remote sensing citizen science mapping algorithms machine learning environmental policies habitats mpas blue carbon governance
Multi-material additive manufacturing for lightweight and thermal management (MULTHEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Luxembourg,Netherlands,Ireland,Italy,France,United Kingdom
Call: Functional multi-material components and structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 4071977.25
EU funding (EUR): 4071977.0
Participants: 10
Project status: SIGNED

The 26th Climate Change Conference has highlighted the urgent need to reduce global carbon dioxide emissions to limit global warming. The transport sector accounts for approx. 16% of the global carbon emissions and has identified fleet electrification as the primary route to achieving climate neutrality. However, the main challenges are the current weight of components and the cost of new systems to ensure efficiency and long-term sustainability. As a result, the industry has recognised the need for transformative technologies and production methods to develop lighter, more efficient, and cost-effective solutions to enable this transition and achieve climate neutrality. With their outstanding mechanical strength, Carbon Fibre Composites (CFC) have been increasingly used to replace metals in products requiring lightweight features, such as aircraft or high-performance vehicles. However, due to the traditional manufacturing process and poor thermal conductivity, the use of CFC has been limited to structural applications. For example, batteries, electrical motors, and power electronics, where power losses need to be efficiently dissipated, typically require separate heat exchangers, resulting in heavier and less cost-effective solutions that still utilize bulky designs and heavy materials. The vision of MULTHEM is to develop a reliable and validated Additively Manufactured (AM) CFC process with enhanced thermal conductivity with different material combinations and nanotechnology. This innovative approach will allow the development of components, such as battery and motor housings with dual functionality comprising structural and cooling features and with a more cost-effective approach than traditional methods. This solution will enhance the product performance, first by the weight reduction achieved by designs that only AM enables, and second, by using CFC-metal structures with enhanced thermal conductivity strategies, lighter and stronger than aluminium or steel.

Keywords: additive manufacturing,multi material,material extrusion,carbon fiber reinforced polymers,laser melting deposition,robotic fsw,joining technologies