Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding and Preserving Early Islamic Jericho: Towards a Management Plan for the Site of Khirbet el-Mafjar (Palestine). (JERICHO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-08-01
End date: 2016-07-31
Duration (months): 24.0
Total project cost (EUR): 308587.8
EU funding (EUR): 308587.8
Participants: 1
Project status: CLOSED

Khirbet al-Mafjar is the most outstanding and best preserved Umayyad palace in the Near East and represents the first steps in the development of early Islamic architecture. It was built by the Umayyad Caliphs in their pursuit of a new visual culture and a theatre for their protocol apparatus, reinforcing their political identity, while establishing an instrument for territorial control in the making of the newly established Caliphate. It stands nowadays as an essential component of the Palestinian identity, and a basic landmark of their Cultural Heritage. The main objective of the project is to conduct interdisciplinary research on this complex, assessing its present condition and reviewing previous research, in order to draft a Management Plan which will guarantee its preservation and public enjoyment. The project involves researching how Cultural Heritage can become an engine of socio-economic development, a tool to reinforce the cultural identity of the local population and in the establishment of intercommunity dialogue that might help in the resolution of the current conflict.The fragmentary character of previous research was due mainly to approaches applied, as well as to political vicissitudes related to its location. This proposal intends to make an important step forward by building up an analytical strategy based on the methodological principles of Archaeology of Architecture, using the monument as a document, a stratified repository of material and social information about its transformation and change of use, gathering all sources of information into interdisciplinary interpretative models. This integration of archaeological, technological and historical research of the built heritage with its preservation and management provides the chance of finding in the material culture sources of historical and technological information which offer simultaneously the choice to understand its History and to provide technical knowledge required for its preservation.

Keywords: early islamic architecture & archaeology,building archaeology,landscape archaeology,documentation,digital media,preservation & management of cultural heritage,cult.heritage and development aid
Functional Imaging and Robotics for Sensorimotor Transformation (FIRST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-03
End date: 2016-04-02
Duration (months): 24.0
Total project cost (EUR): 277296.8
EU funding (EUR): 277296.8
Participants: 1
Project status: CLOSED

This proposed research addresses the question of how the brain transforms somatosensory information from the hand into motor commands to control the hand during tasks such as object manipulation and dexterous finger movements. Understanding the sensorimotor transformations performed by the brain to control upper limb movement is fundamental for a variety of fields, including motor development, athletic and artistic performance, sensorimotor rehabilitation, assistive technology and humanoid robotics. This project will investigate and model the computational processes underlying the sensorimotor transformations taking place in the brain during dexterous movements of the hand in neurologically normal individuals and individuals with impaired hand function following a stroke. This will be achieved by creating a set of novel haptic tasks implemented on state-of-the-art high fidelity haptic devices and quantifying the changes in performance and brain activity that occur as the tasks are learned. The changes in functional connectivity within brain networks as the tasks are learned will be used to determine how sensorimotor transformations are carried out in the brain. The performance measures and the way in which haptic features such as texture, compliance and shape are related to changes in motion and force during learning of the haptic tasks will be used to develop a computational model of how somatosensory information is transformed into commands to muscles that control the hand. Differences in changes in functional connectivity in brain networks between neurologically normal individual and post-stroke subjects during learning of haptic tasks will be used to advance our understanding of changes to the sensorimotor network of the brain following stroke. The computational model will be used to investigate the mechanisms responsible for differences in performance.

Keywords: hand,haptic interface,tactile discrimination,somatosensory system,fmri,resting-state networks,functional connectivity,diffusion tensor imaging,communicability,stroke
Plasticity and adaptation of hydraulic traits to overcome climate change (HYDROPIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 375597.5
EU funding (EUR): 375597.5
Participants: 1
Project status: CLOSED

The increase in CO2 concentration and globalscale trends of rising temperature will have progressive and cumulative effects on especially forested ecosystems. It is largely debated whether forest trees will be able to adapt in situ fast enough to outstrip the higher frequency of extreme phenomena. In this sense, the long-term acclimation of the structure-function relations of the hydraulic system seems to play a key role to assure tree resilience. In HYDROPIT we will identify which hydraulic traits involved in adaptation are likely to show important plastic responses to particular changing environmental conditions and to develop predictors to enable us to generalize about the sorts of species likely to exhibit these plastic responses. Those traits will be then examined in the light of projected climate conditions: experimentally raised CO2 concentration. To achieve these objectives the project will be implemented in three stages: 1) the study of phenotypic variability in natural populations growing in contrasted climatic conditions; 2) the disentanglement between genetic and environmental effects in hydraulic traits using a common garden and 3) the assessment of acclimation in the first-ever full FACE (i.e. free-air CO2 enrichment). This project will contribute to a consistent worldwide quality reference for the development of strategies that may be useful for public administrators, forest owners, industry and non-governmental organisations in order to enhance integration of adaptive strategies in forest management planning.

Keywords: climate change,drought,forest resilience,phenotypic plasticity,acclimation,plant hydraulics,xylem structure and function
Chemistry of Marine Natural Products from the Mediterranean. (CHIMICAMARINAANAPOLI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-12
End date: 2017-02-11
Duration (months): 24.0
Total project cost (EUR): 249242.8
EU funding (EUR): 249242.8
Participants: 1
Project status: CLOSED

Bioactive marine natural products from nudibranchs and other marine organisms from the bay of Naples – Marine natural product chemistry is a dynamic field of research with most of the compounds currently known having only been discovered since 1990 and with an ever increasing number of newly discovered compounds per year. Marine invertebrates including organisms that are vulnerable to predators are a particularly interesting source of bioactive natural products, which often constitute their most important means of defence. Apart from the sheer numbers still to be discovered, newly discovered marine natural products also encompass unexpected new carbon skeletons partially featuring new bioactivities based on formerly unknown modes of action. Equally interesting as the elucidation of the structure of marine natural products is the elucidation of their ecological role for the organisms producing them. These studies are made more complex because of emerging evidence that microbes associated with marine invertebrates may be the true producers of many of the natural products that were previously assumed to be produced by their invertebrate host. In the course of the proposed project, marine natural products from the Mediterranean and the Bay of Naples in particular, will be isolated and their structures elucidated by modern spectroscopic techniques. Pharmacological activities of these compounds will be tested in collaboration with other groups in fields of bioactivity which will be based on the structure of the isolated compounds and on some preliminary in-silico screenings. The focus of the investigations will be on nudibranchs but will also include other not yet studied marine organisms, in particular if ecological considerations make them interesting objects of study. In this respect, the focus will be on species which have been introduced or migrated to the Mediterranean only recently.

Keywords: natural products,marine natural products,nudibranches
Identifying Inflammatory Bowel Disease causative genes through trans-eQTLs mapping within GWAS loci (TRANS_CEDAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

Life-time prevalence of inflammatory bowel disease (IBD) is reaching an alarming rate of > 1/400 in industrialized societies. Improved understanding of disease pathogenesis is essential to develop more effective preventive, diagnostic and therapeutic measures. Genome-wide association studies (GWAS) have identified ~ 160 risk loci contributing to inherited predisposition to Crohn's disease and/or ulcerative colitis. While this has already led to the identification of new perturbed pathways and potential drug targets, causative genes and variants remain unknown for the vast majority of risk loci. Moreover, the identified risk loci only account for an estimated 25% of inherited risk. GWAS loci are likely to be regulatory and therefore alter expression levels of other genes. In the present project we propose to apply an integrated genomic and transcriptomic approach to identify novel genes and pathways that are causally involved in inherited prediposition to IBD. We aim to detect causative genes implicated in IBD’s susceptibility through the evaluation of trans-eQTLs within GWAS loci. Trans_CEDAR is based on the generation of an integrated dataset of nine cell/tissue types collected on 350 healthy caucasians individuals, as well as on the use of next generation sequencing to identify rare variants in functionally-incriminated candidate genes. We expect to detect new causative variants that may constitute new drug targets. The present project will also generate a map of trans-eQTL in different tissues, equally useful for the study of other diseases, to be shared with the scientific community.

Keywords: inflammatory bowel disease,trans-eqtl,causative genes,rare variants
Infinite-dimensional Lie theory and Kac-Moody groups (KMLIEGROUPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

Lie theory was created at the end of the 19th century, and rapidly became a central chapter of contemporary mathematics. Finite-dimensional Lie groups and Lie algebras were extensively studied for more than a century, and are well understood. In attempting to generalise the finite-dimensional objects, one can roughly distinguish two general approaches, one "analytic" (keeping the smooth manifold structure of Lie groups) and the other “algebraic” (which is best represented by the algebraic constructions of Kac-Moody groups). Although intensively studied, Kac–Moody groups and Lie groups beyond the affine case remain mysterious to a large extent, and many questions concerning their structure remain open. In my Ph.-D. thesis, I established several structure results concerning topological Kac–Moody groups of indefinite type, and part of this research project carries on this study further. The main goal of this research project is to get a better understanding of Kac–Moody groups beyond the affine case, from both the analytic and algebraic approaches, and to try to construct “concrete realisations” of these groups (at least for hyperbolic types), by studying the unitary representations of their Lie algebra. More precisely, my method would be to try to construct certain “concrete” representations of a distinguished class of Lie algebras that include all symmetrisable Kac–Moody algebras; it should then be possible to construct “concrete realisations” of the corresponding groups by integrating these representations, hopefully allowing for an in-depth study of these groups. This research project would allow me to significantly broaden and diversify my mathematical knowledge and experience, as I would study Kac-Moody groups and algebras from a wholly different perspective (the "analytic" one) and investigate its applications to theoretical physics, thus placing my research in an interdisciplinary context.

Keywords: kac-moody groups and algebras,infinite-dimensional lie groups,representation theory of infinite-dimensional lie algebras and groups,locally compact kac--moody groups
The Privacy Policies of Internet Intermediaries: High-tech Responsibility in the Multi-stakeholder Nexus (INTERNET PRIVACY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-12-01
End date: 2016-11-30
Duration (months): 24.0
Total project cost (EUR): 308587.8
EU funding (EUR): 308587.8
Participants: 1
Project status: CLOSED

This project advances and interrelates two new conceptual insights – i.e. the ‘high-tech responsibility’ and ‘multi-stakeholder nexus’ concepts – and uses these concepts to conduct an empirical analysis of the privacy policies, and broader political context, of the four internet intermediaries (IIs) that dominate the European search engine and social media market: i.e. Facebook, Google, Microsoft and Yahoo! The project employs inductive top down theorizing to construct the two concepts that provide a ‘sensegiving’ function to the project’s problem domain, and uses archival (internet) research, network analysis, and automated semantic network analysis, to empirically analyse the project’s problem domain. The project is at the cutting-edge of research in corporate social responsibility (CSR)/organization studies and internet governance/privacy, and addresses a problem domain of pressing importance to European Union states and citizens. The project contributes to Europe’s research excellence by strengthening ties between leading European scholars and research centres; by contributing to the development of a new field of interdisciplinary scholarship of broad societal importance; and by providing European researchers with ‘first mover’ advantage in this interdisciplinary field. The project will support the researcher’s career development through significantly advancing his long-term career plan to elaborate political understandings of CSR and multi-national corporations (MNCs). It will develop his research approach/methodology, and advance his interdisciplinary knowledge of internet governance/privacy and MNCs. Copenhagen Business School (CBS) – the host institution – has interdisciplinary expertise in CSR/organization studies, internet governance/privacy, and communicative research methods. Accordingly, and given CBS’s ‘business in society’ research strategy more generally, CBS provides the perfect work environment for the project.

Keywords: business ethics,corporate social responsibility,global governance,internet governance,internet privacy,multinational corporations,organization studies,multi-stakeholder.
Functional Genomics Analysis of Neisseria meningitidis interactions with human dermal blood vessels in vivo (HUVASC-SEQ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

Neisseria meningitidis is still the major cause of bacterial meningitis and septicemia worldwide. The septic shock caused by Neisserial invasive disease is characterized by the presence of skin lesions (petecchial rashes and purpura). Despite the strong association of meningococcal disease and purpura as well as the serious prognosis associated with it, the bacterial factors and physiological processes underlying these events at molecular and cellular level are still largely undescribed. Here we propose to use a recently developed humanized-mouse model of meningococcal purpura to study by functional genomics (Transcriptome analysis and gene fitness analysis by High-throuput insertion track sequencing, HITS) the host-bacteria interactions during the process of vascular colonization by N.meningitidis in vivo. We expect that combination of these two approaches would highlight bacterial and host mechanisms important for vascular colonization. By the combination of cellular and biochemical approaches we expect to dissect these mechanisms and elicit bacterial determinants used to colonize and proliferate in human blood vessels and host molecular mechanisms that participates in causing vascular damage and purpura fulminans in response to bacterial infection. Understanding the details of vascular leakage may also give indications as to how N. meningitidis are able to cross the Blood Brain Barrier and cause meningitis. This experimental approach could have the potential to highlight suitable targets for future innovative meningococcal therapeutics and vaccines development. Futhermore, this project will give to the fellow the opportunity to learn scientific, technical and complementary skills, which could support his career development to become an independent researcher in the field of host-pathogen interactions.

Keywords: health sciences,infections,neisseria meningitidis,humanized mouse model,in vivo model,blood vessels,transposon mutants,functional genomics,vascular biology
How spontaneous telomeric fusions occur: unravelling new pathways required for end protection (TELOSCREEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-01
End date: 2016-08-27
Duration (months): 24.0
Total project cost (EUR): 196510.0
EU funding (EUR): 196510.0
Participants: 1
Project status: CLOSED

Telomeres are DNA-protein complexes that reside at the end of the chromosomes. These are key structures in order to prevent loss of genetic information and DNA damage activation at the chromosome termini, thus avoiding genomic instability, which can potentiate tumorigenesis. When a telomere became dysfunctional, for example by loss of telomeric proteins or due to telomere shortening, the DNA damage machinery is activated and the chromosome ends are processed as DNA breaks. This leads to checkpoint activation and repair through chromosome end-joining. Although many have studied how telomere fusions arise in the absence of key telomeric components, the formation of spontaneous end-to-end fusions is still poorly understood. Here we propose to dissect how spontaneous telomere fusions arise. For that we will use as model organism Schizosaccharomyces pombe, which telomeres have great similarities with the mammalian ones. Using a state-of-the-art plasmid assay we will conduct a transposon-based genetic screen in order to unravel new proteins required for the formation of telomeric fusions in a wild-type and unperturbed system. We will then focus on the clearest candidates from the screen and determine their role in telomere biology. Moreover, and in order to further understand how spontaneous telomeric fusions arise, we also aim to investigate the role of telomeric replication in this process. The fact the telomeres are long stretches of repetitive DNA sequences and also due to the formation of secondary structures, replication can be a challenging event, potentiating loss of telomere integrity. Altogether, we foresee that this project will make a key contribution to our understanding of telomere dysfunction. Importantly, studying how spontaneous fusions arise and finding new components required for end-joining will also give new insights on how a normal cell can become tumorigenic.

Keywords: yeast,replication stress,genetic screen,telomere,telomerase,end-to-end fusions,shelterin complex,deep sequencing,s. pombe,end replication problem,dna damage,checkpoint activation