Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Alkali-Metal-Mediated Metallation (MEDIATED METALLATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

The metal-hydrogen exchange reaction (metallation) is one of the most fundamental synthetic tools. Traditionally, bases such as lithium alkyls have been used for the deprotonative metallation of aromatic rings; however, their high nucleophilicity restrict their use with certain sensitive functional groups. Professor Mulvey’s group have shown that special synergic effects can be induced by mixing an alkali metal base with certain magnesium or zinc reagents, leading to revolutionary new mixed-metal reagents that can perform reactions impossible with traditional single metal reagents; introducing the new concepts of alkali-metal-mediated magnesiation (AMMM) and alkali-metal-mediated zincation (AMMZ). For example, toluene can be regioselectively twofold deprotonated at the 2,5-ring positions in a reaction with a mixed-metal Na/Mg compound, that is outside the scope of conventional organometallic bases, which generally attack the more acidic Me group. Recently, this novel chemistry has been extended to a transition metal (manganese) thus pioneering the idea of alkali-metal-mediated manganation (AMMMn). This project will investigate the AMMMn of a variety of organic substrates and the extension of this synergic methodology to other transition metals (cobalt, chromium, iron and nickel) or indeed other main group metals such as tin. Some of these synergic complexes have been described as “inverse crowns”, most of them involving alkali metal-magnesium partnerships. New chemical opportunities can be opened (redox chemistry, catalysis, magnetochemistry and anion complexation) if inverse crowns could be synthesised in which magnesium is replaced by any divalent transition metal. The final aim of this project will therefore be to synthesise and structurally characterise a series of transition metal host inverse crowns. The project will provide an excellent training (air- and moisture- sensitive synthesis) combining aspects of inorganic, organic and supramolecular chemistry.

Keywords: inorganic chemistry,organometallic chemistry,alkali-metal-mediated metallation,chemical synergy,main group chemistry,structural chemistry,synthetic chemistry,inverse crowns
Quantum dynamics at conical intersections (QDYNCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-07
End date: 2010-04-06
Duration (months): 24.0
Total project cost (EUR): 178874.06
EU funding (EUR): 178874.06
Participants: 1
Project status: CLOSED

We aim to understand better the effect of conical intersections on chemical reaction mechanisms. Our approach will be to investigate the conditions under which resonance states can be induced in which the wave function is temporarily trapped in the upper cone of the intersection. Such ‘Slonczewski resonances’ are very likely to occur in a variety of chemical reactions, although very little is yet understood about the conditions under which they form. By trapping the system in such a state, one can expect to enhance certain reaction pathways over others, and to generate quantum interference which could favour particular outcomes of a reaction. We will carry out calculations in close collaboration with experimental groups, including the Zare group at Stanford. We will concentrate on two reactions (the hydrogen-exchange reaction, and the non-adiabatic quenching reaction of OH + H2) in which there is a strong chance of finding Slonczewski resonances. The challenging wave packet calculations will use the codes developed over the past 6 years in the Althorpe group, which use a system of absorbing and reflecting potentials to evaluate the propagations efficiently. The results will be analysed using a newly developed topological method, which has already proved very powerful in explaining the (experimentally observed) disappearance of Geometric Phase effects in the hydrogen-exchange reaction. This research provides excellent and apt training for the Marie-Curie Fellow, allowing him to extend his expertise on the electronic structure side of conical intersections to the quantum dynamics side. The EU is without doubt leading the world in the area of non-adiabatic dynamics and control, and hence the Fellow will be in a good position to develop further an exciting scientific research career within the EU.

Keywords: conical intersections,quantum reaction dynamics,quantum control
Hierarchical self-assembly of electroactive supramolecular systems on pRe-patterned surfaces: multifunctional architectures for organic FETs (HESPERUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-08
End date: 2010-04-07
Duration (months): 24.0
Total project cost (EUR): 162985.98
EU funding (EUR): 162985.98
Participants: 1
Project status: CLOSED

HESPERUS aims at enabling cross-disciplinary training and research at the interface between Electrical Engineering, Supramolecular Chemistry, Materials- and Nano-Science and Physics. The overall goal of HESPERUS is to generate new scientific and technological knowledge by combining supramolecularly engineered nanostructures (SENs), mostly based on organic semiconductors, with tailor-made interfaces to textured solid substrates and electrodes, for fabricating prototypes of two-terminal devices (supramolecular wires) and three-terminal devices (field-effect transistors). The training and research objectives of HESPERUS are: 1. Surface texturing: derivatization of electrically conductive solid substrates and metallic nanostructures to achieve a full control over the surface work-function, wettability and adhesion, thus ultimately to be able to tune the self-assembly of electroactive molecules at surfaces into pre-programmed supramolecular assemblies. 2. Hierarchical self-organization on textured surface of multifunctional SENs based on electrically/optically active functionalized carbon-based (I) 2D nano-objects such as n- and p-type discotics (perylenediimide and hexabenzocoronene derivatives) and (II) polymeric multichromophoric architectures at surfaces on the functionalized substrates. 3. Nanochemistry and nanoprobes: Scanning probes (AFM, STM, KPFM, C-AFM) quantitative time and space resolved characterization of various physico chemical properties of SENs, in particular correlation between structural and electronic properties. 4. Fabrication of supramolecular wires and transistors: Measurement of charge mobility in SENs two- and three-terminal devices varying systematically the wire’s (1) chemical composition, (2) conformation, (3) length and (4) doping.

Keywords: chemical engineering,physical chemistry,nanoelectronics,macromolecular chemistry
SUstainable PROduction of GALanthamine by both in vitro and agricultural crops of highly galanthamine-containing plants (SUPROGAL)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Spain,Bulgaria,Poland,Netherlands,Germany
Call:  (FP7-SME-2007-1, 2007)
Start date: 2009-02-01
End date: 2011-03-31
Duration (months): 26.0
Total project cost (EUR): 1343680.0
EU funding (EUR): 787160.0
Participants: 7
Project status: CLOSED

Galanthamine is an alkaloid produced exclusively by plants of the family Amaryllidaceae, mainly belonging to the genus Galanthus, Leucojum and Narcissus. Owing to its acetylcholinesterase inhibitory activity, galanthamine is used and marketed for the treatment of the Alzheimer’s disease, among others. Although it is obtained by organic synthesis, galanthamine is also being extracted from natural sources. Both Galanthus and Leucojum plants are very widespread in the Eastern European countries, whereas Narcissus plants are mainly distributed in the Mediterranean region. For industrial purposes, Leucojum aestivum plants are gathered from wild populations in their natural habitat, which causes increasing problems regarding quality of the plant material as well as depletion pressure on the natural populations of L. aestivum. By development of an in vitro production method, both problems will be overcome. Narcissus confusus, an endemic species growing in Spain, was found to produce around two-fold higher amount of galanthamine than L. aestivum. Both plant species will also be propagated and subjected to further agronomic studies for the initiation of new crops of highly galanthamine-containing plants. Integrating both research approaches, the initiation of new crops of L. aestivum and N. confusus and the establishment of the in vitro production method, will result in the development of a sustainable production method of galanthamine. Since galanthamine in Europe is produced by highly specialised SMEs, significant improvement in this field can only be achieved by cooperation on European level. The co-operative research implemented in the SUPROGAL project will thus markedly improve the competitiveness of the involved SMEs.

Keywords: leucojum aestivum,narcissus confusus,amaryllidaceae alkaloids
Crystallographic and biochemical studies of the human TBX5-Nkx2-5-DNA complex (TBX5-NKX2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-01
End date: 2010-12-31
Duration (months): 24.0
Total project cost (EUR): 158127.84
EU funding (EUR): 158127.84
Participants: 1
Project status: CLOSED

Holt Oram syndrome (HOS) is a heart and limb syndrome, which manifests itself in 1 of 100000 live births. HOS syndrome is an autosomal-dominant disease, where forelimb and cardiac congenital abnormalities are observed. The syndrome is connected to mutations in the T-box transcription factor TBX5 gene. Similar symptoms are observed when mutations in the homeobox transcription factor human Nkx2-5 are present. TBX5 and Nkx2-5 interact with each other and synergistically activate the promoters of the cardiac-specific natriuretic peptide precursor type A (ANF) and connexin (cx40). The project goal is the biochemical characterization and crystal structure solution of the ternary TBX5-Nkx2-5-DNA complex. The crystal structure of the ternary complex will allow a comprehensive structural analysis of the interaction mechanism between TBX5 and Nkx2-5 and their DNA binding sites and will elucidate the synergistic promoter activation of TBX5 and Nkx2-5 on a molecular level. Such insight is of broad interest for cardiovascular biologist because it opens the ultimate perspective to use this knowledge for influencing cardiac growth and for cardiac regeneration. The results of this project will contribute to the European quality and competitiveness in cardio vascular research. The project uses the full portfolio of structural biological research and requires interdisciplinary knowledge in molecular biology, biochemistry, biophysics, protein crystallography and bioinformatical techniques. Thus, the researcher has the possibility to gain skills in all techniques necessary for doing successful research in structural biology. In addition, the multidisciplinary environment at the EMBL will give the researcher the possibility to interact and communicate with scientists in fields other than crystallography. All mentioned points will allow the scientist to gain professional maturity and to develop an independent research career.

Keywords: cardiovascular diseases,holt oram syndrom,transcription factor,ternary protein-dna complex,structural biology,protein crystallography,biophysics,protein biochemistry,molecular biology
Space and Time Resolved Ultrafast Dynamics of Few Porphyrins Derivatives in Nanosystems (FENASY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-02
End date: 2009-12-01
Duration (months): 18.0
Total project cost (EUR): 120934.23
EU funding (EUR): 120934.23
Participants: 1
Project status: CLOSED

In this project (FENASY), we wish to study fast (picosecond regime, ps) and ultrafast (femtosecond regime, fs) dynamics of some (guests) porphyrins derivatives in solutions and confined in chemical and biological nanocavities and nanochannels provided by cyclodextrins, Human Serum Albumin protein, and MCM-41 zeolite. The guests and hosts are being used in different fields of Science and Technology. We will interrogate their photoreaction and relaxation dynamics and study the effect of nanoconfinement on the related and subsequent elementary events at both ps and fs time scales. Powerful techniques based on ultrafast laser and single molecule technologies will be our tools to carry out FENASY. We will then focus on studying the relationship between the photodynamics (time domain) and nature and size of the formed nanostructure (space domain, nano to micrometer domain). The expected results will allow explaining the relaxation behaviour of these important molecules upon excitation to Soret and Q- bands, and the relationship to their photochemistry in solution and for the first time within chemical and biological nanocavities and nanochannels. We believe that the expected results will be of great interest to the scientific community in designing new derivatives of these and other systems for use in nanotechnology (nanoLED’s, nanostwitches, etc), nanodrugs (nanophotodynamics therapy of cancer), and environmental science (heavy metal nanocleaning). Key words. Femtochemistry, single molecule fluorescence microscopy, porphyrins, nanocavity, cyclodextrins, protein, zeolites, dynamics, emission, absorption, nanotechnology, biotechnology, environmental science, photodynamic therapy.

Keywords: physical sciences,chemistry,femtochemistry,photochemistry,nanomaterials,nanostructures,confined media,ultrafast dynamics
Production of hypoallergenic soy products exhibiting bioactive peptides throughout fermentation technology (BIOPEPCURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-06-01
End date: 2011-03-22
Duration (months): 30.0
Total project cost (EUR): 187221.13
EU funding (EUR): 187221.13
Participants: 1
Project status: CLOSED

With respect to allergenicity, soybean ranks in the “big 8” of the most allergenic foods and the incidence rate is projected to markedly increase with increasing consumption. The aim of this research is to provide an adequate fermentation process that will allow reducing allergenicity enhancing the safety and availability of soy-derived products to sensitive individuals providing at the same time new bioactive peptides that may prevent age-related chronic diseases. These approaches will be of significant relevance to the community, decreasing health care costs by preventing allergic reactions and age-related chronic diseases. Moreover, the knowledge gained from this study will help to improve future soy products transferring the results of this project to the food industry. Identifying bioactive proteins and peptides in fermented soy products will give soy food manufacturers the ability to increase value-added to soy products. This multidisciplinary Project will provide the candidate with a high knowledge of food chemistry, nutrition, proteomics and cell biology and will contribute to her complementary skills. The benefits gained will be the final requirements for becoming and independent and mature professional in food, nutrition and biosciences.

Keywords: food safety,food quality,food products,food technology
Constitutional Law in the Age of Circulation of Factors of Production (CONCIRCLAW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 161225.98
EU funding (EUR): 161225.98
Participants: 1
Project status: CLOSED

The aim of the research proposal ‘Constitutional Law in the Age of Circulation of Factors of Production’ (CONCIRCLAW) is to test how and to what extent EU law of free movement a) is transforming some of the key concepts of member states’ constitutionalism such as citizenship, equality, political participation and judicial review of legislation b) is developing a form of constitutional law at supranational level which, both substantively and procedurally, maintains important elements of divergence from the states’ traditional template. By this research, it is expected to contribute to the ongoing debate on European integration and constitutionalism by bridging the gap existing in the constitutional scholarship on the relationships between comparative constitutionalism and the law of free movement. The training profile of the research is oriented at strengthening the skills of the applicant in both the fields of comparative constitutional and free movement law. To this purpose. a programme of training through research is devised according to an empirical approach based on selected case-studies in which the intersections between the two disciplinary fields at issue become evident.

Keywords: comparative constitutional law,law of free movement,european integration
Enlarging the ERA-MORE network: the Mobility Centre Luxembourg (MOC LUXEMBOURG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Luxembourg
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2008-05-01
End date: 2011-10-31
Duration (months): 42.0
Total project cost (EUR): 395220.0
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

The Mobility Centre Luxembourg aims at being a new link in the ERA-MORE network, setting up procedures, services and networking in order to help incoming researchers organise their research stay in Luxembourg. The project amounts to structuring comprehensive information on all aspects involved in a research stay and making it available through an Internet Portal linked to the European Researchers' Mobility Portal, a help desk and communication tools. The Minister for Culture, higher education and Research has entrusted the University of Luxembourg with this task. With the help of a steering group involving the main public research institutions of Luxembourg, it will coordinate all actions towards welcoming researchers on a national level and will also help coordinate actions on a European level.

Keywords: researchers' mobility era-more european network
Language contact in the eastern Mediterranean in the Late Middle Ages : Greek in a multilingual society (GREEK IN CONTACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 161398.35
EU funding (EUR): 161398.35
Participants: 1
Project status: CLOSED

The project aims to investigate the extent of language contact in the eastern Mediterranean in the Late Middle Ages (13th – 17th c.).It focuses on Medieval Greek,which became a locus point of multilingualism,because of the socio-political environment,i.e. the contact between Greek- and Romance-speaking populations developed in large parts of eastern Mediterranean after the fall of Constantinople to the Franks (1204).Consequently,the main emphasis of the investigation will be placed on language contact phenomena between Greek and Romance languages,as manifested predominantly in Greek.The project aspires not only to describe developments of Greek,but also to determine the wider language contact situation.It comes to address a long awaited desideratum of the relevant research,since the issue of multilingualism in the medieval Mediterranean has only been examined in relation to the notorious ‘lingua franca’ and the various loanwords incorporated into different languages,while the proposed research focuses instead on the almost totally unexplored morphosyntactic level.The research will be carried out on the basis of a corpus compiled of literary and non-literary texts (the latter mostly unknown to the linguistic research so far) written in Greek,with a view to control for the register factor on the data evaluation.The philological expertise necessary for the examination of the texts and their authors,as well as the essential knowledge of the socio-political environment in which the texts were produced speak for the multidisciplinary character of the project,even beyond the linguistic borders.The examination of language contact in such a multi-ethnic environment can become relevant for the current political state of affairs,because of the mobility of the population in EU;the linguistic outcome of roughly similar situations in the past can prove to be helpful not only in the evaluation of current linguistic developments,but also in language planning at the political level.

Keywords: historical linguistics,comparative linguistics,medieval greek,language contact,late middle ages,eastern mediterranean,romance,morphosyntactic level,multilingualism,non-literary texts