Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Designer recombinases for efficient and safe genome surgery (GENSURGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 2380425.0
EU funding (EUR): 2380425.0
Participants: 1
Project status: SIGNED

Recent breakthroughs in the field of genome editing provide a genuine opportunity to establish innovative approaches to repair DNA mutations to replace, engineer or regenerate malfunctioning cells in vitro or in vivo. However, most of the recently developed technologies introduce double-strand DNA breaks at a target locus as the first step to gene correction. These breaks are subsequently repaired by one of the cell intrinsic DNA repair pathways, typically inducing an abundance of insertions and deletions (indels). Ideally, for many applications genome editing should, however, be efficient and specific, without the introduction of indels. Site-specific recombinases (SSRs) allow precise genome editing without triggering endogenous DNA repair pathways and possess the unique ability to fulfill both cleavage and immediate resealing of the processed DNA in vivo. However, customizing the DNA binding specificity of SSRs is not straightforward. With this project, we propose to solve this shortcoming. We have already demonstrated that by applying substrate-linked directed evolution, SSRs can be generated that specifically recognize therapeutic targets. The objective of this project is the development of a universal genome editing platform that allows flexible, efficient and safe gene corrections in cells of any origin without triggering cell intrinsic DNA repair. GenSurge aims to: i) sequence an unprecedented, comprehensive compendium of evolved SSRs to understand the directed molecular evolution process at nucleotide resolution; ii) integrate the knowledge obtained in i) to develop a unique SSR-based approach to correct genomic inversions; iii) develop a universal SSR-based strategy that allows flawless, precise and safe genome editing to correct any gene defect in human, animal or plant cells. The successful implementation of this project will deliver a comprehensive, safe and efficient platform from which genome surgery-based cure strategies can be initiated.

Keywords: genetic engineering,genome editing,side specific recombination
Autoantibodies and chronic pain - Unraveling new mechanisms contributing to pain in rheumatic disease (ANTIBODYPAIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1993763.0
EU funding (EUR): 1993763.0
Participants: 1
Project status: SIGNED

Pain is one of the most problematic symptoms of rheumatic disease such as rheumatoid arthritis (RA) and fibromyalgia (FM). We have earlier discovered that antibodies (immunoglobulin, IgG) purified from blood of seropositive rheumatoid arthritis (RA) patients induce pain-like behavior when transferred to mice, independent of inflammatory reactions. Even though FM is not considered an autoimmune disease, it has been suggested that neuroimmune dysregulation contribute to the pathogenesis. Therefore, we purified IgG from FM patients and found that also IgG from FM patients, but not healthy controls, have pronociceptive properties in mice, and surprisingly, bind to satellite glial cells in dorsal root ganglia. Our findings highlights the importance of expanding our view on which chronic pain conditions that could have an underlying autoimmunity as part of the pain pathology. Thus, the overall objective of this project is to investigate both general, and disease specific, pain-inducing mechanisms mediated by RA and FM IgG. Objective 1. Investigate how IgG from RA and FM patients induce pain-like behavior after transfer to mice Objective 2. Search for RA and FM IgG induced maladaptive changes in sensory neurons that mediate hyperexcitability and long-term pain-like behavior Using patient and healthy control samples, in vivo mouse behavioral assays, primary neuronal and non-neuronal cell cultures together with stat-of-the-art methodology, we will investigate how RA and FM-associated autoantibodies alter sensory neuronal excitability. If successful our project will not only challenge the view of how antibodies can contribute to pain but also pin-point specific mechanisms by which disease-relevant antibodies induce and maintain pain independent of previously described inflammatory mechanisms. Such findings promise to resolve currently unanswered questions concerning symptoms of pain in RA and FM, and to pave the way for the development of new pain-relieving therapies.

Keywords: pain,osteoclasts,satellite glial cells,autoantibodies,immune complex,fc receptors,nerve injury,calcium imaging,electrophysiology,transcriptional regulation,microrna,circrna,smfish
Deciphering and reversing the consequences of mitochondrial DNA damage (RevMito)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Türkiye,Finland
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1497160.0
EU funding (EUR): 1033640.93
Participants: 2
Project status: CLOSED

Mitochondrial DNA (mtDNA) encodes several proteins playing key roles in bioenergetics. Pathological mutations of mtDNA can be inherited or may accumulate following treatment for viral infections or cancer. Furthermore, many organisms, including humans, accumulate significant mtDNA damage during their lifespan, and it is therefore possible that mtDNA mutations can promote the aging process. There are no effective treatments for most diseases caused by mtDNA mutation. An understanding of the cellular consequences of mtDNA damage is clearly imperative. Toward this goal, we use the budding yeast Saccharomyces cerevisiae as a cellular model of mitochondrial dysfunction. Genetic manipulation and biochemical study of this organism is easily achieved, and many proteins and processes important for mitochondrial biogenesis were first uncovered and best characterized using this experimental system. Importantly, current evidence suggests that processes required for survival of cells lacking a mitochondrial genome are widely conserved between yeast and other organisms, making likely the application of our findings to human health. We will study the repercussions of mtDNA damage by three different strategies. First, we will investigate the link between a conserved, nutrient-sensitive signalling pathway and the outcome of mtDNA loss, since much recent evidence points to modulation of such pathways as a potential approach to increase the fitness of cells with mtDNA damage. Second, we will explore the possibility that defects in cytosolic proteostasis are precipitated by mtDNA mutation. Third, we will apply the knowledge and concepts gained in S. cerevisiae to both candidate-based and unbiased searches for genes that determine the aftermath of severe mtDNA damage in human cells. Beyond the mechanistic knowledge of mitochondrial dysfunction that will emerge from this project, we expect to identify new avenues toward the treatment of mitochondrial disease.

Keywords: yeast,mitochondrial dna,mitochondrial disease,proteostasis,molecular genetics,model organisms,unbiased screens and selections
Production harmonizEd Reconfiguration of Flexible Robots and Machinery (PERFoRM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Italy,Germany,Germany,Italy,Germany,Sweden,Switzerland,United Kingdom,Portugal,Portugal,United Kingdom
Call: Flexible production systems based on integrated tools for rapid reconfiguration of machinery and robots (H2020-FoF-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 9162025.0
EU funding (EUR): 7094095.0
Participants: 19
Project status: CLOSED

PERFoRM - Production harmonizEd Reconfiguration of Flexible Robots and Machinery aims to the conceptual transformation of existing Production Systems towards plug&produce production systems in order to achieve a flexible manufacturing environments based on rapid and seamless reconfiguration of machinery and robots as response to operational or business events. These objectives require research activities to implement a solid Manufacturing middleware based on encapsulation of production resources and assets according existing paradigms (e.g. CPS, Service based architectures, Cloud services, etc.), the development of advanced and modular global monitoring and optimization algorithms for reconfiguration of machinery, robots and processes and, finally, to ensure the full interoperability, the harmonization and standardization of methods and protocols to enable the plug-and-produce readiness in heterogeneous environments. On the other hand, real industrial and business impacts, can be achieved by careful consideration of migration of legacy environments to the new approach and, where standard devices and/or applications remain, the coexistence and integration of existing systems. Implementing a robust and consistent KPI based operational and performance measuring approach, to really drive the behavior of the system according to the business and operational objectives, will ensure the achievement of measurable results. To such purpose PERFoRM project will deploy in four industrial testbeds belonging to different industrial domains to ensure a broad and sound validation of the concept and the platform. A successful deployment will be achieved not only by focusing on migration planning and deployment, but will also encompass the deployment in at least two designated industry driven experimental testbeds to optimize the deployment strategy and so minimize risks.

Keywords: industrial middleware,plugandproduce,harmonization,standardization,reconfigurability,flexible production systems,kpi based production control
A Unified Integrated Remain Well Clear Concept in Airspace D-G Class (URClearED)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Germany,Germany,Italy,Italy,Sweden,Belgium,United Kingdom
Call: Remain Well Clear for IFR RPAS Integration in Class D-G Airspace (H2020-SESAR-2019-2, 2019)
Start date: 2020-05-01
End date: 2022-10-31
Duration (months): 30.0
Total project cost (EUR): 1945801.25
EU funding (EUR): 1631767.5
Participants: 8
Project status: CLOSED

In the URClearED project, starting from a clear knowledge of the current status of the activities that are currently on-going, relevant steps to support the RWC functions of such a DAA system are intended to be carried out, strictly interacting with the projects on-going and those that will start in the time frame of the present project. In short, the project aims to support current study activities on the RWC functionalities by defining and analyzing operational scenarios which allow to assess requirements and assumptions made in current standards and applicable documents, and then paving the way to future industrial level activities on such system. the above overall objective will be pursued through: - define a set of operational scenarios which are peculiar to integration of an IFR RPAS into Class D-G airspaces, by taking into account current assumptions and requirements as defined in the EUROCAE-OSED [REF-1] (but also draft OPA, OSA, MASPS under development), also analyzing input from all other relevant focus groups and projects; - develop a full Remain Well Clear (RWC) functionality of a DAA system, which supports evaluation for the operational conditions in integrating RPAS in Class D-G airspaces; - define a set of scenarios for verification activities; - carry out both Fast-Time Simulation and Real-Time simulation-Human in the Loop (both Remote Pilots and Air Traffic Control Officers) which allow to analyze such scenarios and provide validation and possible enhancements/amendments to EUROCAE OSED, as long as performance, safety (including Human Factors) and interoperability requirements; - assess Surveillance Sensors performance requirements; - Integrate the most advanced CA system available, as developed in relevant European projects (MIDCAS, MIDCAS SSP, SESAR PJ10-05 Wave 1, SESAR PJ111 & 117 Wave 2) for the full evaluation of the DAA system. - Dissemination to the relevant stakeholder groups, including participation to standardization activities.

Keywords: integration of rpas,detect and avoid,separation management
NEW PATHWAYS TO GENDER AND EQUALITY IN RESEARCH AND INNOVATION IN THE EUROPEAN UNION (NEWPATHWAYS)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Finland
Call: Stocktaking of 20 years of Gender equality in Research and Innovation (H2020-SC5-IBA-GENDER-2018, 2018)
Start date: 2019-06-01
End date: 2020-05-31
Duration (months): 12.0
Total project cost (EUR): 238750.0
EU funding (EUR): 191000.0
Participants: 1
Project status: CLOSED

This is a proposal for a two-day conference to be held in 23-24 October 2019 in Helsinki under the topic of gender equality in research and innovation. The among the objectives of the conference are the following: 1. The proposed Conference will hold discussions that provide the basis for future action under four general themes: • Institutional or structural change of gender equality in research and innovation. • Intersectionality, diversity and other dimensions of equality in research and innovation to complement the gender equality dimension. • Gender equality dimension in the fields of digitalization, artificial intelligence and robotics. • Gender equality in innovation activities, especially in the private sector. These themes connect the conference to the ongoing discussions and developments in the research and innovation area. 2. Another important objective is to focus on the future of equality in research and innovation and the next steps necessary to ensure progress for the future strategy and actions at national EU and global level. 3. The Conference will also look at the achievements of the past 20 years and lessons learned in European gender equality policy development in particular with established instruments, involvement and collaboration. One of the main focus of the Conference will be to discuss how to utilize what we have learned in bringing forth a new and improved vision for gender issues in research and innovation.

Keywords: gender,equality,research,innovation,conference
Mereological Reconstruction of the Metaphysical System in the Daodejing (Mereodao)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Poland,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2023-03-31
Duration (months): 36.0
Total project cost (EUR): 229500.0
EU funding (EUR): 229500.0
Participants: 2
Project status: CLOSED

The project is a mereological reconstruction of the metaphysical system in the Daodejing. The general motivation for the project is to fill the gap in Chinese and comparative philosophy the state of the art, where mereological as well as analytic reconstructions are scarce. The specific motivation is that mereological approach enables precise reconstruction that (a) offers a comprehensive conceptualization of Daoist metaphysical system and (b) allows to generate the issues and plausibly debates that so far have not been present in Chinese metaphysics. My project begins with the conceptualization of the Daoist system as monistic-materialistic one, after which I proceed to the mereological reconstruction. By resorting to the latest mereological research, I will analyze the status of the two fundamental elements of Daoist metaphysics, dao and you. Accordingly, I will show that these two ontic subregions should be reconstructed as two different mereological sums determined by atemporal unrestricted composition and temporal restricted composition respectively. Next, I will proceed to reconstructing the relation between the two sums, which will be conceptualized within the framework of Chinese causation theory. I will show that causality applies to the relations between parts that that the two mereological sums overlap. Next, I will proceed to a detailed reconstruction of the whole system, which will involve among others proving that with regard to parthood, the “atomless gunk” conception is more plausible than that of mereological singles. I will also discuss how the reconstruction is related to location, an issue that has been under intense discussion in contemporary mereological literature.

Keywords: chinese philosophy,comparative philosophy,daoism
The trusted solution for issuing certified documents to the blockchain, checkable in just a click (Smart Certificate)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Like in many other sectors, fraud in the recruitment industry is estimated to play part in more than a third of employment applications. In a world where all parties can no longer trust each other, the whole system is being undermined. Trust is thus an essential but complicated concept to build, which remains fragile to maintain, and so easy to destroy. To tackle above mentioned challenges, we have developed Smart Certificate™, a secure platform to generate and share any kind of certified document and make its verification accessible online with one click. Our core innovation lies on the patented method and security architecture about how to create, share and check any kind of certified documents safely. From the personal data privacy point of view, institution, wanting to verify credential for recipient, needs first authorization from the person. This is a key issue proven by the market, where our platform solves it in the smartest way: by generating the credentials at the source and provide them with easy to use service directly to graduates and citizens. We foresee our closest benchmark for our entry market value proposition as a sub segment of education technology - the Learning Management Systems (LMS) market. The LMS market is expected to grow from €4.3 Billion in 2016 to €12.9 Billion by 2021, at a CAGR of 24.7%. CV Trust was launched in 2010. We are an international team of seasoned entrepreneurs with validated vision to create a true label of trust for the education world, job market and beyond. We have already serviced over 70 customers in the education sector. Upon completion of the project, we expect to reach project ROI of 9.79 by 2025.

Keywords: credentials,fraud,blockchain,education technology,security
Populism And Civic Engagement – a fine-grained, dynamic, context-sensitive and forward-looking response to negative populist tendencies (PaCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Iceland,Ireland,Finland,Bulgaria,Belgium,United Kingdom,United Kingdom
Call: Addressing populism and boosting civic and democratic engagement (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-02-01
End date: 2022-04-30
Duration (months): 39.0
Total project cost (EUR): 3003308.75
EU funding (EUR): 2998558.75
Participants: 10
Project status: CLOSED

Across Europe there is a rise of political movements that claim to challenge liberal elites and speak for the 'ordinary person' - movements that can be loosely categorised as 'populist'. Many of these movements have undesirable tendencies. The Populism and Civic Engagement project (PACE), with others, aims to combat the negative tendencies of populist movements, to build upon the lessons of positive examples (such as Reykjavik), and hence play a part in constructing a firmer democratic and institutional foundation for the citizens of Europe. PACE will analyse, in detail, the type, growth and consequences of such movements in terms of their particular characteristics and context. From this, it will analyse the causes of these movements and their specific challenges to liberal democracy a possibilistic analysis to complement survey/statistical approaches. In particular, it will focus on transitions in these movements (especially changes in leadership) as well as how they relate to other kinds of movements and the liberal reaction. PACE will propose responses to these challenges, developing risk-analyses for each kind of response, each kind of movement and the type of transition. For this, it will employ the agent-based simulation of political processes and attitudes to allow for thorough risk analyses to be made. Throughout the project, it will engage with citizens and policy actors, especially groups under-represented in public affairs, face-face and via new forms of democratic participation appropriate to our digital age to help guide the project and to comment on its outputs. It will develop new tools, based on machine-learning algorithms for identifying and tracking populist narratives and to aid online consultation. It will result in specific interventions aimed at: the public, politicians, activists and educators. It will look further into the future, developing new visions concerning how we could respond to populism and it will warn about longer-term trends.

Keywords: populism,agent based simulation,policy analysis,narratives,machine learning,public engagement,causal analysis,nativist,democracy,liberal,anti elitist,scenario development