Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Micro-physiological circadian platform for safety and efficacy assessment of drugs and cosmetics (mP-CSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tissue Dynamics Ltd. is a groundbreaking biotechnology company focused on developing smart microphysiological platform technologies for drug, food, and cosmetic development. Pharmaceutical and cosmetic companies face huge costs of developing and testing new products (an average of €2.5B to develop a single drug), which is increasing over the years. Traditionally, these tests have been carried out in animal models whose limitations in predicting human responses are significant (70% of drugs toxic to humans are not toxic to animals). These limitations lead to the withdrawal of many drugs in the market, making drug development a costly risky process. Organ-on-chip platforms, developed in recent years, have proven to be a better alternative to current laboratory models, offering more physiological and similar characteristics to the human body. Tissue Dynamics goal is to provide a functionally scaled Multi Organ-on-Chip (MOC) platform that uses real-time sensing of tissue function to detect the effect of drug-induced physiological stress in multiple 3D vascular organs (liver, heart, brain, kidney). Our latest innovation has been the incorporation of factors that mimic circadian rhythms in the organs, which is essential to test the physiological impact of the compounds tested. On the other hand, the incorporation of the circadian rhythm in our chips enhances the development of treatment schemes, adjusting in a more precise way the dose and the time of administration of the medications, seeking the maximum efficacy of them. The global Organ-on-Chip market is a rapidly-growing, estimated to reach $6.13 Billion by 2025, with an expected growth rate of CAGR 69.4%. Our platform will reduce the cost of new drugs development ultimately, helping patients by making more safe and effective medicines reach the market. In turn we expect ROI of 5 after five years of commercialization and hire 10 new employees.

Keywords: organ on chip,pharmacology,chronopharmacology
Removing endotoxins during sepsis: a blood purification platform using magnetic nanoparticles (MagnoBeads)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hemotune is a Swiss academic spin-off company founded in 2017 to commercialize proprietary blood purification technology using uniquely designed magnetic nanoparticles, developed at ETH Zürich. Hemotune is financially supported by Wyss Zurich and the Gebert Rüf foundation to develop a product to treat sepsis. Sepsis affects 19 million people each year, and with a mortality rate of 30% it is the most common cause of death in intensive care units. Currently, no cure for sepsis exists, and treatment focuses on relieving symptoms. Therefore, a huge market opportunity exists for curative sepsis treatments, which is estimated to reach €4.3 billion by 2026. Using its proprietary blood purification technology, hemotune aims to capitalize on this market opportunity by developing a dialysis-like device that removes endotoxins (molecules responsible for sepsis) from the blood. This device employs magnetic nanoparticles to selectively capture endotoxins, which are subsequently filtered out of the blood by a magnetic filter. By removing these endotoxins, the septic response is halted, stabilizing the patient. This technology was successfully tested in small-scale animal models, and now R&D activities will focus on developing a human-sized prototype product, ready for clinical evaluation. Financial support from the SMEi phase 1 will be used to assess the technical and commercial feasibility of the nanoparticle-based blood purification platform as a treatment strategy for sepsis. Technical feasibility includes usability engineering, and feasibility studies into the upscaling, and into regulatory feasibility to receive market authorization. Commercial feasibility entails a freedom to operate analysis, and composition of solid IP and commercialization strategies. This SMEi phase 1 feasibility study, combined with the ongoing R&D delivering the prototype product, put hemotune in an excellent position to rapidly move forward towards clinical trials.

Keywords: sepsis,septic shock,endotoxins,blood purification,magnetic,therapy
Graph convolutional neural networks for neutrino telescopes (GraphNeT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2025-08-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: TERMINATED

While it is currently undergoing rapid developments, the neutrino sector still has many open questions: the neutrino mass hierarchy is not known, several parameters of the PMNS matrix are poorly constrained, and the inability to explain the nonzero neutrino masses is a clear indication of physics beyond the Standard Model. Neutrino oscillation experiments at the IceCube Neutrino Observatory may be able to address these fundamental questions, but the reconstruction of neutrino interactions in the detector is a challenge which urgently needs to be addressed: the current reconstruction algorithm is prohibitively time-consuming, cannot account for all known optical anisotropies in the ice, and cannot make full use of all of the information from new modules in the IceCube Upgrade due to excessive computing time and memory requirements. This project proposes graph convolutional neural networks (GCN) as a machine learning paradigm excellently suited for neutrino telescope experiments, with potential to revolutionise reconstruction in IceCube. GCNs impose no structural requirements on data, requiring only a concept of adjacency, naturally afforded by the spatial, temporal, and causal separation of hits in the detector. With expected improvements in particle identification of a factor of 10 compared to analytical methods and a factor 10,000 speed-up in reconstruction, GCN-based reconstruction will be developed and implemented in the IceCube-DeepCore oscillation analysis, to better measure PMNS parameters by improving the atmospheric muon background rejection and performing per-flavour event categorisation. Powerful and fast GCN-based reconstruction will benefit several physics analyses in IceCube --- and possibly ANTARES, KM3NeT, and Baikal-GVD --- and help answer the open questions in the neutrino sector. Finally, the possibility for private and public sector partners to benefit from these high-performance GCN tools will be explored through intersectional partnerships.

Keywords: icecube,deepcore,very large volume neutrino telescopes,graph convolutional neural networks,neural networks,deep learning
SOIR instrument Open science of the Venus upper atmosphere (SOIROpenVenus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-28
End date: 2023-05-21
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Venus, our closest neighbour after the Moon, is an important planet to study: although it is very similar in size and Sun-distance when compared to the Earth, both planets evolved in very different manners. For this reason, studying the structure, dynamics, composition and chemistry of the Venus atmosphere is an major aspect of planetary science, as it helps to understand more about our Solar System in general. Indeed, many Venus atmosphere related questions remain unanswered, and this projects aims to address important open key questions. This project proposes a study of the Venus mesosphere and thermosphere at the terminator region, using solar occultation transmittance spectra that were measured by the SOIR instrument on board the ESA Venus Express spacecraft (2006-2014). The objectives of the proposed research project are (i) to characterize the two main Venus chemistry cycles, i.e. the sulfur and the carbon oxide cycles, and the deuterium/hydrogen ratio, and (ii) to study the wave dynamics, while (iii) making the results available to the community based on an open-science approach. Even though many species and temperature vertical profiles were retrieved during the mission timeframe using the SOIR spectra (CO2, CO, H2O, HDO, HCl, HF, SO2), some species absorbing in the SOIR wavenumber range were not studied (OCS, H2S, DCl, DF, NH3, HBr and HI); no cross-correlations between these species, which are involved in the different Venus chemical cycles, were examined. Furthermore, the observed short-term extreme variability in terms of species relative abundances and thermal structure was never characterized. We propose here (1) to complete the SOIR profiles molecular database, (2) to study the dependence between the species that contribute to the same chemical cycles and to characterize the variability, (3) to release the data products using existing open-base solutions and to disseminate the results through outreach activities.

Keywords: venus,retrieval,atmosphere composition,atmopshere dynamics,open science
Improving Market Access for Farmers: Evidence from East Africa (AGRIMKT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499913.0
EU funding (EUR): 1499913.0
Participants: 1
Project status: SIGNED

Agriculture employs the majority of the labor force in many developing countries, particularly in Sub-Saharan Africa. Increasing efficiency of agricultural production is a crucial step to foster economic development. Limited access to both input and output markets is widely considered a major obstacle to technology adoption and, in turn, to agricultural productivity. In this proposal, I outline a research program that focuses on improving farmers’ market access in East Africa. The research builds on the expertise I have developed on these topics over the last ten years. The research program consists of three related projects. In Project A, we will use a randomized experiment to evaluate the impact of a holistic approach to improve market access: contract farming. The prevalence of contract farming arrangements in the developing world is growing. However, so far, there is no experimental evidence on their impact. We have established a partnership with a large contract farming company in Kenya, which has agreed to randomize the order in which it will expand to new villages. In Project B, we will study how to increase demand for crop insurance among smallholders. Building on previous successful experimental work, we will test i) whether offering pay-at-harvest insurance, as opposed to upfront premium pay, raises take-up, ii) which behavioral mechanisms may drive such response, and iii) whether pay-at-harvest can foster sustained insurance demand over multiple crop seasons. In Project C, we will combine parcel-level proprietary data for three decades that we obtained from a large agribusiness company with land registry data to study the determinants and impact of land market access for smallholders. The research program will generate new insights on how to improve access to key markets for agricultural producers. We expect the findings of the study will generate high interest among academics, development practitioners, and policymakers.

Keywords: agricultural markets in africa,contract farming,agricultural insurance
A user-friendly approach to widespread gas monitoring (Stick-n-Sense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Stick&Sense aims at making gas monitoring technology accessible to everyone. In a moment when society is more and more aware about the risks related to airborne pollution, the market is failing at providing a gas monitoring solution suitable for a massive, widespread use. Stick&Sense addresses, all-in-one, the main limitations of existing technologies: it is a disruptive one-stop solution capable of offering low cost, low complexity, high selectivity, good durability and broad detection range. Stick&Sense is a new colorimetric-electronic device consisting of a new low-cost optical reader and a new gas-specific colorimetric sticker designed to change its colour in presence of a target gas, that will operate together just attaching the sticker to the reader. With this genuine concept, Stick&Sense will offer an easy-to-use system for a wide range of gas sensing and monitoring applications, enabling a rapid expansion, not only among the traditional industry users, but also towards new, non-exploited mass consumers applications with millions of potential users. In short, Stick&Sense can revolutionize how people know the risks around them and relate with their environment to improve life-quality, safety and health. In this project, we will design and produce the first minimum viable demonstrator of the technology that will serve us to validate the Stick&Sense effectiveness both at a technical and at a commercial level. The team hosts all the expertise needed to implement this PoC from a technical and from a business points of view and counts with an extensive network of industry contacts to partner with in customer discovery, validation and eventual tech transfer agreements. The key innovations of the Stick&Sense solution have been recently discovered in ERC-funded activities and its technological core (the reader chip) patented; thus, all its innovation potential can be captured if the here-proposed test, validation and knowledge transfer activities are carried out now.

Keywords: gas sensors,colorimetry,disposable
Provision of specialist office equipment for a ESR with a physical disability (INIA - ESR2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2020, 2020)
Start date: 2021-03-01
End date: 2024-08-31
Duration (months): 42.0
Total project cost (EUR): 3615.0
EU funding (EUR): 3615.0
Participants: 1
Project status: SIGNED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: cubital tunnel syndrome,disability,ergonomic equipment
Innovative highly concentrated Omega 3 food supplement (LIFEOMEGA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project aims to develop an innovative food supplement consisting on a high concentrated emulsion of Omega-3 fatty acid EPA. Omega-3 is utilized as a treatment in psoriasis, arthritis, asthma, multiple sclerosis, chronic inflammatory, cancer, high TGs, retinal diseases and cardiovascular failure. It consists of 15 ml liquid concentration of EPA, minimizing the level of saturated fats. It’s high concentrated -3 grams EPA/ sachet–, so it allows meeting the nutritional requirements in fewer dosages. Similar products in the market are constituted of maximum 1 gr. EPA, in which a higher concentration means higher level of saturated fats. Liquid form permits the dilution in other liquids, as milk, soup, or juice. These features permit the following applications: 1) Clinical nutrition: most of cancer patients suffer cachexia or anorexia. EPA supports weight management, reduce the pro-inflammatory response and improve quality of life. 2) Dietary supplement: EPA helps maintaining the musculature and protecting the joints, so it is ideal for competition athletes. Innovation is present in all aspects: application, as the multiple emulsions technology is applied to food products – normally it is applied in cosmetic or pharma-; product, as there are no products in the market offering such a high EPA concentration in liquid form minimizing the saturated fats; design, as it has liquid form; and solution, as the mentioned features constitute a solution for people having an extra requirement of fatty acids. Goal in phase I is to develop a feasibility study, including a business plan which will cover all aspects of commercialization of LIFEOMEGA: technical, economical, risk assessment, IP, regulatory, bottle necks, market study, partner search, among others. LIFEOMEGA has a great potential, as it is estimated that cancer patients receiving chemotherapy unfortunately won’t be less than 1 million/year during the next 11 years, in USA, Spain, France, Germany, UK and Italy.

Keywords: food supplement,dietary supplement,nutritional requirement,dietary management,oncological,patient,fatty acids,cancer,omega 3,high concentration,multiple emulsion,clinical nutrition
Demonstration of a cloud-based precision farming management system for a sustainable and intensive agriculture to secure long-term food supply in Europe - Phase II (AgriCloud P2)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Germany,Hungary,Poland,Latvia
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2016-05-01
End date: 2018-08-31
Duration (months): 28.0
Total project cost (EUR): 1359000.0
EU funding (EUR): 951300.0
Participants: 4
Project status: CLOSED

This phase 2 proposal targets the pilot application and market introduction of AgriCloud, a cloud-based precision farming (PF) management system for more efficient, sustainable production of crops in Europe. The objectives are: final technical development, product demonstration through field trials with six pilot customers, market launch in five selected EU countries and market replication leading to a turnover of 28 m € within 5 years after launch. Today, most farmers manage their crop by gut feeling, leading to inappropriate fertilization, plant damage and unnecessary environmental impact. AgriCloud is the first holistic FP approach, processing all available data from agronomic sensors, machinery and service companies and, backed by plant nutrition expert knowledge, facilitates a targeted use of fertilisers and herbicides, efficient machinery utilisation and workflow management. Farmers are operating a mixed stock of stand-alone agricultural machinery. AgriCloud meets their need for integrated solutions with only one data infrastructure for a coordinated, easy-to-use machinery control from one user interface. By using AgriCloud, they will increase yield production between 3-10%, reduce lodging to 50-100%, reduce fertilisers by 12-20% and improve harvest efficiency by 12-20%. Their annual savings amount to approx. 130€/ha, which enables amortization of the AgriCloud invest within 1-1.5 years. The EU agricultural industry faces the challenge of responding to an increasing demand for food whilst at the same time having to ensure the sustainable use of resources. The Commission already identified PF as a key technology to solve this problem. However, European farmers have not yet adopted PF due to draw backs of existing solutions. AgriCloud is able to solve those bottlenecks and contributes to Europe’s drive towards more competitiveness and long-term sustainability in agriculture as well as towards the recent EU Common Agriculture Policy (CAP).

Keywords: intensive agriculture,precision farming,variable rate application,cloud based precision farming,management,farm management
Checking Assumptions aND promoting responsibility In smart Development projects (CANDID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Norway,United Kingdom,United Kingdom
Call: Enabling responsible ICT-related research and innovation (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2017-12-31
Duration (months): 12.0
Total project cost (EUR): 566290.0
EU funding (EUR): 566290.0
Participants: 5
Project status: CLOSED

This project will study aspects of the 'smart' agenda in which practitioners from the Social and Human Sciences (SSH) offer unique and valuable insights of relevance to innovators and researchers in the ICT - LEIT[1] areas. Centred on topics concerning of users, design, digital rights and critical infrastructures, CANDID will engage SSH and ICT - LEIT researchers in ‘extended peer communications’ aiming at Responsible Innovation.

Keywords: smart,users,digital rights,infrastructures,social and human sciences,anticipatory governance,ethics,smart city,smart home,ict design