Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding long-term FLOOD pattern variability in Western Mediterranean using natural ARChives (FLOODARC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 2
Project status: CLOSED

Society is becoming more vulnerable to natural climate variability through increasing exposure of people and infrastructure. Notably, floods are among the most destructive natural hazards causing widespread loss of life, damage to infrastructure and economic deprivation. Robust knowledge about their future trends is therefore crucial for the sustainable development of societies worldwide, particularly in sensitive areas such as Western Mediterranean. This Marie Sklodowska-Curie Action (MSCA) aims to provide a more comprehensive understanding of the long-term variability of hazardous (high-impact) floods at different temporal and spatial scales. Through this action the Experienced Researcher (ER) will work within the Hydro-Meteorology, Climate and Society Interactions (HMCIS) group at the Host Institution (IGE) to develop a high-impact flood database in Western Mediterranean. State-of-the art statistical tools applied to the flood database will allow the ER i) to evaluate, for the first time, the causes of non-stationarity in the long-term flood pattern evolution at a sub-continental scale and; ii) to investigate the role of the climate variability on the high-impact flood patterns at centennial to millennial time-scales in W Mediterranean. The ER has expertise in high-resolution proxies of flood events contained in lacustrine and fluvial sediments. He aims to obtain specific training in geo-statistical tools applied to Flood Hydrology at the Host Organization. This MSCA project will significantly contribute to the career development of the researcher and will enhance our current understanding of the natural variability of floods and its trace in the sedimentary record. Therefore, this study will help to address major concerns in relation to flood hazards and adaptation strategies in line with the European engagement with climate change (EU report 2012, Horizon 2020, Climate Action) and the EU Floods directive (2007/60/EC).

Keywords: paleoflood,western mediterranean,statistics of extremes,paleohydrology
Solution-Based Engineering of Nanodimensional Phase-Change Materials and Memory Devices (NanoMMs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1604600.0
EU funding (EUR): 1604600.0
Participants: 1
Project status: SIGNED

Phase-change memory (PCM) is a recently-commercialized next-generation memory storage technology that provides a sustainable solution to exponentially-growing memory storage demands of modern society. It is based on resistively switched structural changes of memory cell upon local crystallization and melting phase transitions, resulting in amorphous or crystalline atomic structures with distinctly different “0” and “1” resistance states. PCM is faster and more durable than state-of-the-art non-volatile memory devices like silicon-based solid-state drives (SSD), and it can furthermore be scaled in all three dimensions. However, there are open challenges for PCM technology, such as large power consumption and high price of PCM devices, which stem from large dimensions of memory cells, complex fabrication process, and from use of material-inefficient sputtering and etching fabrication steps for the expensive PCM layer. This proposal addresses the open challenges and enables further development of PCM technology by applying solution-based engineering. Our goals are (i) to develop robust synthetic approaches for PCM materials, such as ternary tellurides and antimony-rich compositions, in the form of colloidal nanoparticles and molecular ink precursors; (ii) to thoroughly study how PCM properties change at the nanoscale as a function of size, thickness, and composition; and (iii) to employ these phase-change nanomaterials in solution-processed PCM arrays to build new, ultrasmall PCM configurations as well as multilayer PCM cells and to reduce their price and power consumption.
Re(defining) CD4+ T Cell Identities One Cell at a Time (ThDEFINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 1980685.0
EU funding (EUR): 1778456.25
Participants: 2
Project status: CLOSED

The immune system consists of a complex continuum of cell types that communicate with each other and non-immune tissues in homeostasis, and during infections, autoimmunity and cancer. Conventional transcriptional and functional profiling enabled by cell surface marker sorting has revealed a great deal about how specific cell types operate en masse, yet important transcriptional heterogeneity that exists within cell populations remains unexplored. High-throughput single cell RNA-seq can overcome this limitation by profiling entire transcriptomes of thousands of individual cells, revealing cell-to-cell variation by decoding patterns within populations masked in bulk transcriptomes. We will exploit this to dissect the mouse CD4+ T cell compartment, a heterogeneous white blood cell population that initiates adaptive immune responses. In AIM 1, we will chart the dynamics of in vivo CD4+ cell states in mouse before, during and after immune response challenges. By sequencing thousands of single cell transcriptomes, we will map the landscape of CD4+ T cell states in an unbiased, quantitative and comprehensive way. In AIM 2, we will predict key transcription factors, cell surface markers, and signalling molecules, including cytokines/chemokines in each cell state through novel computational approaches. Furthermore, our analyses will establish regulatory modules and networks of gene-gene interactions active in immune responses. In AIM 3, we will (a) confirm the in vivo impact of new cell states by performing adoptive cell transfer assays; and (b) validate our predictions of regulatory molecules and interactions using a massively parallel CRISPR/Cas knockout screen in vitro. This powerful integrated approach combines single cell RNA-sequencing, bioinformatics and genetic engineering to dissect CD4+ T cell states, a central compartment of mammalian adaptive immunity, and reveal basic principles of gene regulation.

Keywords: single cell genomics,bioinformatics,t helper cells
Reliability-oriented Lightweight Optimization Framework for Intelligent Design of Material-structure Integration (ROFiDMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

This project will develop novel topology optimization (TO) methods for the design of multi-scale lattice structures built using additive manufacturing (AM) from porous materials to achieve multiple performance criteria (e.g. stiffness and strength, mass and safety factors, static and dynamic performance). To this end, an intelligent lightweight design concept which combines a novel non-probabilistic reliability-based topology optimization (RBTO) framework and efficient solution algorithms, will be developed for integrated material-structure design (IMSD). The action will, for the first time, address a number of technical challenges in the integrated RBTO design of multi-scale lattice structures manufactured from porous materials, (e.g. accurate evaluation of the mechanical properties of high-porosity microstructures incorporating uncertainties, dynamic reliability prediction of multi-scale lattice structures, and non-probabilistic reliability-based design strategies). The applicant, working with the team at CU will deliver internationally recognized knowledge and techniques in the research field of IMSD

Keywords: uncertainty,reliability based topology optimization,integrated material structure design,non probabilistic reliability,additive manufacturing
In Situ Observation of Batteries for Extending Lifetime (ISOBEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Lithium-ion batteries (LIBs) are a key technology in enabling the transition from a dependence on fossil fuels towards renewable energy sources. However, increased energy density, cycle life, and recyclability are still needed. The different degradation processes in the LIBs are hard to disentangle from post-mortem measurements alone, as intermediate species cannot be detected and changes may occur during cell disassembly. This project aims to apply novel in situ techniques to directly observe the processes involved in transition metal (TM) dissolution, how this affects electrolyte decomposition at the cathode and anode, and the effect on the stability of the solid electrolyte interphase layer. This will be achieved via novel in-situ X-ray photoelectron spectroscopy (XPS) and x-ray absorption spectroscopy (XAS) measurements that allow electrodes and electrolyte to be simultaneously observed during cycling. This understanding will be used to develop solutions to mitigate TM-dissolution and its impact on cycle life. The focus will be LiNixMn(1-x)/2Co(1-x)/2O2 (NMC) electrodes used in many commercial LIBs, where larger energy densities can be achieved by increasing the nickel content. However, this is accompanied by higher levels of side-reactions from the more reactive surfaces. The electrolyte degradation products coming from NMC materials with different nickel content will be identified and prevented from reaching the graphite electrode by using lithium-ion conducting glass to separate the electrodes. This will help finding out how Ni-rich NMC materials can be stabilized and the extent to which cross talk products contribute to ageing. The project will also investigate new ways to recycling aged NMC to enable their re-use in new cells, decreasing the energy consumption in the recycling and avoiding the disposal of costly and toxic elements. This will include developing heat treatment protocols for replenishing lithium content and restoring the initial structure.

Keywords: lithium ion batteries,ageing,recycling,photoelectron spectrometry
Image-based High-resolution In-silico Modeling of Total Cardiac Function (InsiliCardio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-08-31
Duration (months): 30.0
Total project cost (EUR): 218176.2
EU funding (EUR): 218176.2
Participants: 2
Project status: CLOSED

Advances in medical imaging have enabled unprecedented ability to image cardiac anatomy and function. So far these technologies have had relatively modest clinical impact as the analysis of such rich multi-modal datasets has proven challenging. In silico models hold vast potential to better harness such datasets by enabling their integration into quantitative frameworks that can aid in gaining better mechanistic insight into cardiac function in health and disease, and thus paving the way towards optimal therapeutic strategies. Our objective is to develop the most advanced biophysically detailed in-silico model of total electro-mechano-fluidic function of the heart. This model will be parametrized, verified and used to study cause-effect relationships between flow and pressure and their impact upon pumping performance. A novel set of features such as combined models of both heart and attached outflow vessels and the computational efficiency will provide a unique platform for translational research. This ambitious endeavor is feasible only by combining the expertise of the applicant in modeling soft tissue mechanics and his supervisors in modeling electrophysiology (Gernot Plank, MUG) and blood flow (Shawn Shadden, UC Berkeley). Clinical input and datasets for model parametrization and validation are provided by Titus Kühne (DHZ Berlin) and by clinical collaborators of Prof. Shadden at UCSF. During the return-phase, the applicant will use the infrastructure of Prof. Plank’s lab and the large network of academic and industrial collaborations as an incubator for building up his own research group in computational hemodynamics. This is ideal in many regards, as the expertise of the applicant's group will be entirely orthogonal to the expertise in Prof. Plank's lab, thus promoting a fast pathway towards full indepence, and core expertise necessary for further developing and maintaining a highly complex computing environment is synergistically shared between the labs.

Keywords: whole heart model,parallel high performance computing,image based validation studies,anatomically accurate high resolution models,multiphysics simulations
Revealing the cell biology of a predatory bacterium in space and time (PREDATOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1499688.0
EU funding (EUR): 1499688.0
Participants: 1
Project status: SIGNED

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious. My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

Keywords: bacterial cell biology,chromosome replication and segregation,protein subcellular localization,live imaging of bacterial cells,bacterial predation,quantitative fluorescence microscopy
Hearing Matters: European Industrial Doctorate to train experts in auditory implants for minimised outcome spread and maximized participation in society (MOSAICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 1043879.76
EU funding (EUR): 1043879.76
Participants: 3
Project status: SIGNED

The World Health Organisation (WHO) states that 6.1% of the world’s population – 466 million people – has disabling hearing loss, and approximately one-third of people over 65 years of age are affected by it. For people with severe to profound hearing loss, a cochlear implant (CI) is the preferred treatment. However, one of the hallmarks of adult CI outcomes is the enormous variability reported in auditory, speech and language functioning after implantation. Enhanced performance in adult CI users will increase quality of life and allow them to engage more in society, uphold social bonds, independency and jobs. The scope of the MOSAICS European Industrial Doctorate (EID) is to understand, predict, identify, and intervene within in the variation of adult CI users by making use of a holistic and multi-disciplinary approach, bringing together experts from engineering, neuroscience, biophysics, psychology and sociology. Research will be targeted at levels ranging from cochlea to brainstem and auditory cortex, in order to assess the effect of cognition on the performance with CI and vice versa. In addition, societal effects of improving audition and communication after implantation will be investigated. The MOSAICS research and training programme is jointly managedan EID driven by Cochlear, the largest global manufacturer of hearing implants, and the Radboud University Medical Centre, hosting Europe’s leading academic groups in hearing related research, as beneficiaries. Their expertise is complemented by several partner organisations, including four other research groups, two highly specialized SMEs and the European patient organization for cochlear implant users. Synergiesy between both industry and academic partners will enable four early stage researchers ESRs to contribute to the hearing-related innovations and to face the challenges within adult CI care during the entire hearing journey within a highly productive, engaging, and exciting training network.

Keywords: hearing,cochlear implants,holistic framework,participation to society,maximizing outcome in speech perception outcomes,medical engineering,neurocognition,objective measures
Scale-up of an Advanced Manufacturing process to produce a Pharmaceutical product Application (SAMPA). (SAMPA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Ireland
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2020-04-30
Duration (months): 58.0
Total project cost (EUR): 2307500.0
EU funding (EUR): 1600000.0
Participants: 1
Project status: CLOSED

Sublimity Therapeutics has developed an innovative product, ST-0529, to treat patients with moderate-severe Ulcerative Colitis, a disease that affects 1 million patients in Europe. ST-0529 is enabled using Sublimity Therapeutics ’s proprietary SmPill® nanoemulsion-based technology to target a known and powerful drug, Cyclosporine, directly to inflamed colons. In Phase II human studies, ST-0529 was proven to be effective and safe. ST-0529, an oral product, will compete with injected, expensive drugs that have a risk of serious side effects. Successful development and commercialisation of ST-0529 will pivot on development of a stable ST-0529 product and a positive outcome of the clinical trials. Overall, the project will involve leading EU-based specialist SME, technology and equipment suppliers as well as a number of knowledge providers. The budget is €1.6M and will be completed in 58 months. Successful completion of this project will retain and enhance intellectual property and know-how in Sublimity Therapeutics, increase long term high skill jobs. In parallel, the project will unlock the value inherent not only of ST-0529, but also the underlying SmPill® technology platform. Furthermore, the project will increase the probability of overall company success and increase significantly the NPV to more than €500M.

Keywords: advanced manufacturing,nano emulsion,process scale up,process analytical technologies,smpill,cycol,particle visual measurement,raman spectroscopy