Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT) (MULTIMOT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Belgium,Sweden,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Advancing bioinformatics to meet biomedical and clinical needs (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 2999354.0
EU funding (EUR): 2999354.0
Participants: 11
Project status: CLOSED

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Keywords: standardization,repository,integration,meta analaysis,cell migration,clinical applications
Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing (Drug-Seq)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1999900.0
EU funding (EUR): 1999900.0
Participants: 2
Project status: CLOSED

This proposal is centred on the development of small molecule probes derived from DNA damaging agents to identify their genomic targets using a novel unbiased approach. Although, several genotoxic drugs have been used for decades to treat cancers, the exact mechanisms by which they operate are not fully understood. It is established that these compounds interfere with the processes of transcription and replication, thereby promoting genomic instability and cell death. However, there is as yet no genome-wide map of the exact location of sites that are putative targets for these drugs in vivo. This information is critical to understand and rationalize cellular responses to genotoxic agents. Here, we propose to develop an innovative discovery- based methodology that will combine click chemistry in situ, affinity pull-down techniques and high throughput DNA sequencing (Drug-Seq), to identify the genomic interactome of DNA damaging drugs in order to elucidate their cellular activity at the molecular level. Two independent lines of enquiry will be followed. Firstly, we will establish the genomic interacting landscape of landmark drugs including etoposide, camptothecin and cisplatin using Drug-Seq. Secondly, we will perform regular chromatin immuno- precipitation sequencing (ChIP-Seq) of selected proteins linked to the cellular response of interest to validate Drug-Seq and further identify druggable genomic sites. An important aim of this proposal is to establish a universal methodology to decipher small molecule/genome interactions in vivo that trigger a particular response in disease-relevant models. We also seek to interrogate the role of chromatin in regulating drug/genome interactions and to define whether it is possible to act on the epigenome to modulate the activity and specificity of these drugs. Collectively, we anticipate our study will lay down the foundation for personalized medicine with the implementation of rational rather than empirical clinical protocols.

Keywords: organic synthesis,chromatin,cell biology,nucleic acids,dna damage and repair
EXPLORATHON 2020 (EXPLORATHON 2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-03-31
Duration (months): 10.0
Total project cost (EUR): 348039.5
EU funding (EUR): 215892.0
Participants: 5
Project status: CLOSED

Our proposal builds on the success of EXPLORATHON in Scotland from 2014 to date and will deliver a blockbuster edition of the NIGHT across all of Scotland. We will engage with audiences in the main urban centres in Scotland as well as in hard to reach audiences in rural areas and geographically isolated communities in the Highlands and Islands. We will use our full expertise of marketing, social media and styles of engagement to mobilise our researchers and train them to engage with the public. We will use a variety of different styles of engagement from comedy to drama, to online and fun hands-on science experiments to enthuse the public about research and researchers. Working with key partners across Scotland we will showcase to secondary and upper primary aged school children the array of research careers that are on offer and bust myths about researchers.

Keywords: public engagement with research,inspiring young minds,reaching new audiences,innovative engagement,promoting research careers
Development and application of hybrid joining in lightweight integral aircraft structures (DAHLIAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Belgium,France,France
Call: Optimization of hybrid joining (Refill Friction Stir Spot Welding + adhesive bond) for increasing mechanical properties and corrosion protection of the joints [SAT] (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 1033987.5
EU funding (EUR): 953887.5
Participants: 5
Project status: CLOSED

The main objective of the DAHLIAS project is to optimise hybrid joining (Refill Friction Stir Spot Welding, RFSSW, with an adhesive sealant bond) for application in aircraft structures. RFSSW is a solid-state joining technology especially applicable to lightweight alloys in similar and dissimilar configurations. The process has been successfully applied to difficult-to-weld and non-weldable alloys and is considered a potential replacement of mechanical fastening. Overlap joints in aircraft structures require the use of sealants for corrosion protection reasons. Using sealants with an adhesive function would complement the high quality joints produced by RFSSW by not only protecting against corrosion but also contributing to the overall mechanical performance of the structure. To achieve the main goal of this project a work plan consisting of eight work packages has been devised. Two work packages are focused on the RFSSW process development using standard samples with and without adhesive sealant. In parallel the adhesive sealant technology, including surface pre-treatment will be developed. The hybrid joining solution developed in this project will be compared to conventional joining technologies to define its potential. Hybrid joining brings a number of advantages to production and performance of aircraft structures. The change from differential to integral design introduces new challenges in the analysis of mechanical performance. Hence, the damage tolerance behaviour of hybrid joints is also investigated in this project. Quality control methods will be investigated by selecting NDT methods and by process control based on online monitoring of parameters. In the last phase of this project technology demonstrators will be produced to evaluate the capabilities of the proposed technology in actual aircraft structures. The consortium (3 R&D and 2 industrial partners) has the exact fitting, prooven expertise and high excellence. HZG (coordinator) holds key patents.

Keywords: refill friction stir spot welding,rfssw,adhesive sealant,online process control,damage tolerance,technology demonstrators
Innovative Antibiotics to target drug-resistant microbes (D_Bug)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-11-01
End date: 2019-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Antibiotic resistance has become a major public health threat in Europe and the United States where resistant bacteria are directly responsible for ten of thousands deaths per year. The D_Bug project aims to develop innovative antibiotics to target drug-resistant microbes.

Keywords: antibiotics,natural products,enyzme mechanism
superbright, photostabLe and mUlticolour novel fluoresCent mEtal quaNtum clusters for super-resoluTion imaging (LUCENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The breakthrough of super resolution imaging has revolutionized biology and nanomedicine, allowing to visualize synthetic or biological structures with nanometric accuracy and providing a deeper understanding of complex molecular systems. The key idea at the basis of these methods is the use of novel fluorescent markers endowed with specific properties such as photoswitching, reversible binding, stimulated emission and single molecule imaging capabilities. In this emergent framework the fluorescent markers play a role as important as the optical setup utilized for imaging. Therefore, among the prerequisites for successful nanoscopic imaging the selection of the suitable fluorophore is essential. Despite the recent advances in the development of super-resolution microscopy techniques, fluorescent probes with high brightness, high photostability and low toxicity remains an unmet need. This proposal aims at developing ultrasmall photoluminescent atomic metal quantum clusters as new generation of advanced optical probes for super-resolution microscopy. To this purpose, we will apply a combination of property-designed nanochemistry routes and surface engineered strategies for producing multicolour atomic metal clusters that will provide novel model systems for single molecule imaging. The strategy will focus at three important levels: synthesis, biocompatibility and preliminary cellular imaging, application in super-resolution microscopy. The research activity here proposed could realistically lead to live, multicolour, three-dimensional images with an even higher resolution – down to the molecular level – with applications in biology and nanotechnology. To this end, LUCENT will employ a multidiscicplinary approach whose strength resides in the combination of the complementary expertise of the experienced researcher –design of new probes - and the host institution - nanoscopy.

Keywords: luminescent metal quantum clusters,ultrasmall fluorescent probes,super resolution microscopy,multicolour cellular imaging,single molecule imaging
A Consolidated Library of Anglo-Saxon Poetry (CLASP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2443640.0
EU funding (EUR): 2443640.0
Participants: 1
Project status: SIGNED

As elsewhere in Europe, Anglo-Saxon England saw a development from an oral, vernacular, native, and pagan culture to one that was primarily literate, Latinate, imported, and Christian; and such a transition is clearest in Anglo-Saxon verse. CLASP will focus on all surviving verse of Anglo-Saxon England, composed in Old English and Anglo-Latin over a period of over four centuries (c. 670–1100 CE), and produce for the first time an online and interactive consolidated library, marked up through TEI P5 XML to facilitate the identification of idiosyncratic features of sound, metre, spellings, diction, syntax, formulas, themes, and genres across the entire corpus, so forging connections and suggesting more certain chains of influence both within and between the two main literary languages of Anglo-Saxon England. The bilingual corpus comprises almost 60,000 lines of poetry, with about half surviving in each language, and mostly appearing in only a single witness, usually in manuscript. More than fifty named poets are identified, many of them dateable with more or less precision, whose influence on each other can be closely documented, while in the case of anonymous verse, most of which is in Old English, the focus will be on tracing potential influence between texts, to establish a comparative rather than an absolute chronology. CLASP will use the full panoply of digital resources, including sound- and image-files where relevant, to make the oldest surviving poetry in England available to a modern audience for unprecedented kinds of exploration, comprehensive analysis, and interrogation, and in a series of conferences, workshops, and other publications will show the potential of such a comprehensive multilingual corpus to revolutionize perspectives not only on Anglo-Saxon England, but elsewhere in Europe, where Latin and the vernacular likewise co-existed in a Christian context across centuries.
Obsidian Trade at the Onset of the Neolithic in the Near East. Assessing Obsidian Tool Use and Modelling Exchange Networks. (OBSTRADE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

ObsTrade is designed to understand obsidian trade at the onset of the Neolithic in the Near East. Long distance exchange is considered the marker of emergent social networks allowing interactions between distant villages. ObsTrade assumes that these networks improved modes of cultural accumulation of prehistoric societies. This was fundamental for the emergence and transmission of innovations during the transition to farming. For understanding obsidian trade, ObsTrade will investigate what traded obsidian tools were used for and how they were exchanged. The project proposes an original, innovative and interdisciplinary approach, by analysing Neolithic obsidian tool function and geographical distribution. Two cutting-edge methodologies will be applied: 1) the high-precision surface texture analysis through Confocal Scanning Microscopy (CSM) and metrology software for the identification of tool use; 2) the Complex Systems theory and modelling for characterising the obsidian exchange networks and their involvement in the emergence and spread of innovations. An Open Access database (ObsTrade database) containing all data about obsidian presence, geological origins, distribution and use in Near Eastern Neolithic sites will be created. Project results will be made available to the general public through the creation of a graphic novel, and through several outreach activities. The ObsTrade project will allow gaining a better understanding of the mechanisms underlying the formation of the first complex farming societies, using innovative methodologies that will contribute notably to European excellence and competitiveness.

Keywords: use wear analysis,confocal scanning microscopy,obsidian trade,complexe network analysis,diffusion of innovations,prehistoric technology,experimental archaeology
Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes (PROTECT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Ireland,Italy,Israel,Germany,Italy,Spain,Spain,Italy,Germany,Italy,Italy,Italy,Spain,Russian Federation,France,France,Portugal,Portugal
Call: Pilot Line Manufacturing of Nanostructured Antimicrobial Surfaces using Advanced Nanosurface Functionalization Technologies (H2020-NMBP-PILOTS-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 9441862.5
EU funding (EUR): 7478985.0
Participants: 23
Project status: CLOSED

PROTECT aims to introduce to the market One step antimicrobial finish processes for polymeric materials used in i) specialty textiles for public areas and hospitals, ii) water treatment membranes, and iii) implantable medical devices. Compared to main existing manufacturing routes, the proposed one-step coating technologies are simple, fast, and reproducible. For this, PROTECT uses as a starting point four existing pilot lines emanated from high successful FP7 projects SONO, NOVO and BioElectricSurface. PROTECT will upgrade the nanocoating One step process platform comprising: two roll to roll (R2R) pilots (sonochemical and spray coating) for functional textiles production, a R2R thermo-embedding pilot for antibacterial/biofilm preventing water treatment membranes, and a batch sonochemical pilot for antibacterial/antibiofilm/biocompatible medical devices. This platform will cover a wide range of applications due to their specific characteristics by the following objectives: a) Incorporating ‘antibacterial antibiofilm biocompatible novel nanoparticles’(NPs) of the following categories: inorganic (CuxZn1-xO ,5 Ga@C-dots, Si/TiO2 composite) polymer (polypyrrole, PPy)) and biologicals (antibacterial enzymes, functionalized lipids (FSLs), hybrid antibacterials) to obtain ‘biocompatible nanostructured surfaces with antimicrobial and anti-adhesive’ properties. b) Implementing real time characterization methods for monitoring at the nanoscale to characterise relevant materials, process properties and product features for ‘real-time nanoscale characterization’ to ensure ‘reproducibility’ and ‘quality’ of the nano-coated products c) Improving ‘coating efficiency, production capacity, reproducibility, robustness, cost-effectiveness, safety and sustainability’ of the processes in relation to the targeted applications. d) Introducing a Labs Network (PLN) that will include also lab scale processes of the proposed technologies for ‘training and knowledge dissemination.

Keywords: antibacterial textiles,anti biofilmmedical devices,multifunction polymers
Nucleation of Organic Crystals onto 2D materials (NOC2D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-01-31
Duration (months): 77.0
Total project cost (EUR): 1922451.0
EU funding (EUR): 1922451.0
Participants: 1
Project status: CLOSED

The formation of crystalline solids from liquid-phase precursor is a central idea in materials chemistry. Organic crystal structures can be found in a large number of products, including food, explosives, pigments and pharmaceuticals. Control of molecular assembly is therefore a fundamental problem for both research and industry and it involves substantial scientific and economic challenges. For example, polymorphism is crucial for drug manufacturers because the crystal structure, morphology and size, can all affect the stability, efficacy and production cost of the drug. Therefore, it is essential to achieve a deep understanding on the molecular processes happening at the early stage of crystallization. Although important results have been obtained, our understanding on how a crystal of organic molecules nucleates on a surface is still poor. To go beyond state-of-the art we need techniques able to probe rare nucleation events with nanoscale resolution and very high sensitivity, providing direct insights on the structure of the nuclei and their interaction with the environment. The aim of this proposal is to use 2D crystals to open new horizons in the understanding of nucleation of organic crystals by using a multi-disciplinary approach, which combines chemical engineering, material chemistry, graphene physics and sensors technology. Graphene, a single layer of graphite, will allow preparing advanced surface templates and to perform nucleation experiments that would be impossible or too difficult to achieve with other templates. In particular, graphene will be used both as surface template and as sensor to probe nucleation events in real time. We will combine electrical and optical readouts to investigate molecular interactions during nucleation with chemical recognition and nanoscale resolution. This will strongly improve our understanding of the basic phenomena which control heterogeneous nucleation from liquid-phase precursor.

Keywords: graphene,2d crystals,sensors