Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ka-band GaN-based SSPA for flexible payloads and multicarrier operation for 5G satellite concept (FLEXGAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,France,France
Call: Satellite communication technologies (H2020-SPACE-2018, 2018)
Start date: 2018-11-01
End date: 2023-02-28
Duration (months): 52.0
Total project cost (EUR): 2133410.0
EU funding (EUR): 2133410.0
Participants: 5
Project status: CLOSED

5G demand requires the deployment of Very High Throughput Satellites (vHTS) than can satisfy the expected needs implying a growth opportunity for GEO satellites. This kind of spacecraft offers high capacity, large number of users and communication volumes (1 Terabit/s per satellite), with lower cost per GBPS, increasing the flexibility since the satellite capacity is allocated where it is needed. Future vHTS satellites will make use of Ka/Q/V gateways where the forward payload link will operate in K-band. Traditionally, demand for power at high frequencies has resulted in TWTAs as the logical amplifier of choice; this is due to the fact that traditional SSPA technology was unavailable at similar performance levels. However, technological advancements such as linearization, miniaturisation, and the use of different materials such as GaN, have levelled the playing field for SSPAs. The objective of FLEXGAN is to design, develop and test in a representative space environment (TRL 5) a low cost high power and efficient Ka-band GaN SSPA with RF output power varying capability, with high innovative & low loss recombination schemes and able to operate in multicarrier operation mode for on-board 5G satellite applications. The operational frequency band is 17.3-20.2 GHz and the objective output power 125W. The main innovations that FLEXGAN brings are: 1) Bring known terrestrial technologies by TTI to space; 2) SSPA able to provide the required output power maximising the power added efficiency to compensate the downlink fading losses; 3) SSPA able to transmit in multicarrier mode w/o memory effect; 4) Implementation of highly innovative linearization techniques; 5) use of lighweight composite structures to decrease the weight of the overall SSPA. In order to have a 100% European SSPA an MMIC based on D01GH technology from OMMIC will be designed, manufactured and tested. FLEXGAN will allow to reinforce and corroborate the use of GaN technology for space applications.

Keywords: vhts,sspa,gan technology,flexibility,ka band,multicarrier operation,memory effects,trl5
Understanding the identity of the amniotic fluid stem cells (AmnioticID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The amniotic fluid surrounds and protects the foetus during development, providing trophic and mechanical support to its growth. This liquid contains a variety of cells shedding from embryonic and extra-embryonic tissues that have long been utilised for prenatal diagnosis. In a seminal 2007 article, Professor De Coppi identified in the amniotic fluid, a small population of cells with broad multi-lineage differentiation ability defined as Amniotic Fluid Stem Cells (AFSCs). AFSCs can be isolated, expanded and differentiated during gestation, making them ideal for the development of pre-/perinatal autologous regenerative medicine strategies. In the last decade, a series of studies focused on investigating the therapeutic relevance of the AFSCs for various tissue compartments, such as skeletal and cardiac muscle, lung and liver. However, very little is known about the AFSCs origin, lineage identity and role during human development. This knowledge gaps have relevant impact on these cells' clinical translation and a list of important questions remains to be addressed: Which tissue releases the AFSCs? Are these cells constantly generated, or part of a self-renewing niche? What is the function of the AFSCs during human development? This proposal aims at addressing these questions, by using a combination of next generation sequencing analyses, cell biology assays and in vivo linage tracing approaches. Ultimately defining the origin and identity of the AFSCs will not only increase our knowledge of their physiological role, but will also allow to better direct future studies on their therapeutic implications. Thanks to this project, I will gain a comprehensive, multi-faceted understanding of the biology and regenerative potential of AFSCs. This will open up new research agendas, foster international collaborations and provide me valuable transferrable skills of crucial relevance to develop my independent career, in line with the mission of the Marie Curie action.

Keywords: amniotic fluid,lineage tracing,cell identity,next generation sequencing,in vivo imaging mammalian,development
Brain Networks in Learning (BNL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 165085.44
EU funding (EUR): 165085.44
Participants: 1
Project status: CLOSED

The primary visual cortex of the mouse is an ideal model system in which we can study network restructuring during learning, due to the well-described functional properties of its neurons, the existence of a robust learning paradigm, and the feasibility of recording large populations of neurons. Here we aim to identify functional groups of cortical neurons based on the robust estimation of their correlations and observe the topological re-structuring of the network they form. We will build comprehensive Bayesian multi-level models that respect the multidimensional structure of the data for estimation and interpretation of our results. We hypothesize that we will observe major re- structuring of functional cortical sub-networks upon learning.

Keywords: cortex learning in vivo excitatory inhibitory networks graph theory
Not another history of Platonism. The role of Aristotle's criticisms of Plato in the development of ancient Platonism (PlatoViaAristotle)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2335911.25
EU funding (EUR): 2335911.0
Participants: 1
Project status: SIGNED

The conventional historiography of ancient Platonism follows patterns that ultimately go back to Antiquity itself. While these traditional doxographical accounts are not per se inaccurate, they do overlook continuities across different phases of this thousand-year history as well as some unexpected discontinuities. The reason for these shortcomings lies in the fact that certain philosophical debates are being ignored. Some omissions could be detected by searching for the philosophical reasons explaining doctrinal developments. This project chooses an unorthodox approach in that it does not try to reflect the issues emphasised in the sources, but instead selects one particular angle of approach: Aristotle’s critical discussion of Platonic views. By analysing Platonic responses to Aristotle’s criticisms and using these as a heuristic tool, the project pursues a twofold aim: to uncover debates that have hitherto not been picked up in scholarship; and to examine the philosophical reasons for doctrinal varieties and developments. The research hypothesis guiding this project is that Aristotle’s criticism of Platonic philosophy was a driving force for many developments in Platonism. The aims of the project can only be achieved through a large-scale investigation spanning the entire history of Platonism, searching for Platonic responses in all relevant philosophical domains. Since scholarship has been selective in its choice of topics, it cannot be predicted whether we can find sufficient traces of pertinent discussions in all subdomains. Despite the methodological difficulties and the uncertainty of the results the project is more than worth pursuing, as the pay-off is highly significant: it will radically change the way in which we understand the history of Platonism and add a whole new dimension to our historiographical accounts. If successful, it will uncover new debates and allow us to understand philosophical justifications for many philosophical developments.
Light to Store chemical Energy in reduced Graphene Oxide for electricity generation (LESGO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Israel,Spain,Italy,Italy,Spain,Finland,Denmark
Call: FET Proactive: emerging paradigms and communities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-11-01
End date: 2024-04-30
Duration (months): 42.0
Total project cost (EUR): 4193488.75
EU funding (EUR): 4193488.75
Participants: 11
Project status: SIGNED

Hydrogen is being pursued as a promising route to store energy, potentially mitigating the unpredictability of electricity generation based on renewables. Provided that more than 95% of H2 produced comes from breaking the C-H bond in hydrocarbons, it is natural to think that storing H bound to C may provide a long-term solution to this challenge. However, liquid hydrocarbons are not an optimal solution given that the process of extracting H from them involves CO2 emissions. LESGO proposes to store energy in the C-H bond of reduced graphene oxide (rGO-H). rGO-H can be stored safely, exhibits an energy density more than 100 times larger than that of H2 gas, and can be easily transported wherever the electricity generation is needed. LESGO will demonstrate that rGO-H can become an ideal energy stock at an affordable cost and used to supply electrical power on demand where it is required. In the complete cycle from sun light to electrical power the raw material for storage evolves from graphite back to graphite with no CO2 emissions in any intermediate step. LESGO’s consortium has been structured to bring together a highly interdisciplinary community that will enable the emergence of an ecosystem around a circular economy relying on the use of: widely available raw materials, storing energy in chemical bonds, using it in applications that require electrical power, and finally recovering the materials for a second or multiple lives. Industrial (GRAPHENEA, HST, GENCELL and CRF), academic (UDE and AALTO) or research center (IREC and ICFO) activities are completely interwoven throughout the entire implementation of LESGO. Within the duration of LESGO, CRF will develop an application in the transport sector where rGO-H will be tested as the fuel in a support battery providing a fast charging for current electric vehicles. When looking ahead beyond the consortium, DBT will foster the engagement of a wider stakeholder/public community to consolidate the ecosystem around rGO-H.

Keywords: electricity generation,hydrogen storage,electric vehicle,electro catalysis,materials science,nanomaterials,renewal energy,photovoltaics,density functional theory
Emergent Complexity from strong Interactions (EXOTIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 2269197.5
EU funding (EUR): 2269197.0
Participants: 1
Project status: SIGNED

The least understood part of the so successful Standard Model of the strong and electroweak forces is the formation of strongly interacting composites, like hadrons, atomic nuclei and hypernuclei. In addition, the nucleosynthesis in the Big Bang and in stars is fine-tuned at various places, which immediately leads to the question how much these fine-tunings can be offset to still lead to an habitable universe? Over the last decade, the PI and his collaborators have further improved the chiral effective field theory for two- and three-nucleon forces, have pioneered and refined the extension of this approach to baryon-baryon interactions and, most importantly, have developed nuclear lattice effective field theory, which enabled them to solve longstanding problems in nuclear physics, like the ab initio calculation of the Hoyle state in 12C. Based on these achievements, this proposal will provide answers to: i) where are the limits of nuclear stability? ii) what hypernuclei can exist, what are their properties and how is the equation of state of neutron matter modied by the presence of strange quarks? and iii) what limits on the fundamental parameters of the Standard Model are set by the fine-tunings in nucleosynthesis in the Big Bang and in stars? Apart from answering these big science questions, the proposal will, as a by-product, develop methods in effective field theories and Monte Carlo simulations that will be of use in other fields, such as cold atom and condensed matter physics.

Keywords: nuclear stability,hypernuclei,fine tunings in element generation,chiral effective field theory,nuclear lattice effective field theory,monte carlo simulations
Single Molecule Study of Protease Mechano-Specificity (MECHANOPROTEASES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Single-molecule enzymology offers new possibilities to dissect catalytic reactions that were previously unapproachable using biochemistry techniques conducted in the bulk. In particular, recent discoveries conducted at the single molecule level, such as the unanticipated force-mediated protein degradation pathway in the proteasome, highlight the close relation between mechanical forces and proteolysis in vivo. While much has been discovered about protein enzymology in the recent decades, the question of how mechanical force affects enzymatic catalysis remains vastly elusive. The main goal of this proposal is to understand the mechanobiology of proteolysis at the single molecule level. We will use the newly developed force-clamp spectroscopy technique, together with molecular biology engineering techniques and bioinformatics structural analysis to elucidate the molecular mechanisms that underlie protease catalysis under mechanical force. Successful enzymatic activity relies on the enzyme:substrate (E:S) assembly. Upon mechanical unfolding, proteins unveil their buried substrate sites, also called cryptic sites, thus favoring the formation of the E:S complex and ultimately permitting the subsequent chemical reaction. A key feature of recent mechano-chemistry experiments at the single bond level is that the rate at which the reduction of a protein disulfide bond occurs in the presence of a nucleophile is exponentially dependent on the stretching force. Hence, it is tempting to speculate that, in the case of an enzymatic reaction, the catalytic rate will be also force-dependent. We anticipate that the curved geometry of the bound substrate inhibits the E:S assembly at high-forces, implying a novel mechano-specificity character of proteases. Within a multidisciplinary approach, here we propose a series of innovative experiments to directly probe the effect of force on the kinetics of protease hydrolysis.

Keywords: single molecule force spectroscopy,proteases
Bio-strategies of mineral nutrient extraction from silicates by selected microorganisms (Bio-Strategies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project will investigate the mutual influence between minerals, microorganisms and lower land plants and their strategies to release and assimilate metal nutrients from minerals. The study encompasses (1) the habitability of silicate mineral substrates for microbes, (2) the strategies used by microorganisms to obtain metal nutrients from minerals of different nutrient content and resilience to nutrient release, (3) the routes of the metal nutrient from the mineral to the microorganisms and plants. Individual microbes will be inoculated on individual silicate minerals with different resilience to weathering and mineral nutrient content, representing a series of progressively degraded soils or sediments. After these experiments, bathing solutions will be transferred to (1) moss cultures and (2) liverwort cultures with and without fungus symbionts. Microscopic techniques will investigate mineral-microbe interaction, topographic and chemical alteration features in the mineral grains. Chemical analyses will investigate siderophore production, cations dissolved and adsorbed on biofilms, and pH at the mineral-biofilm interface. The bioavailability of leached metals to bryophytes will be measured by chemical analysis of the plants and morphological indications of nutrient stress. Results from bryophytes with and without fungal symbionts will indicate the route of metal assimilation by plant.

Keywords: bacteria,bryophytes,fungi,metal bioavailability,mineral bio weathering
CID (CID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2020, 2020)
Start date: 2021-05-30
End date: 2024-05-29
Duration (months): 36.0
Total project cost (EUR): 12250.0
EU funding (EUR): 12250.0
Participants: 1
Project status: SIGNED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.
Tribbles Research and Innovation Network (TRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Spain,Germany,Spain,Spain,Hungary,France,France,Netherlands,United States,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-11-30
Duration (months): 51.0
Total project cost (EUR): 3818969.68
EU funding (EUR): 3818969.6799999997
Participants: 18
Project status: CLOSED

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects described in the proposal will investigate regulators of these pathways with a focus on a recently described family of pseudokinases, namely tribbles proteins, which have a key role in controlling immunity, metabolism and cancer, and which here will serve as prototypical examples for integrative metabolocentric cancer research. Tribbles are envisaged to contribute directly to the development and progression of prostate cancer, the prognosis of which is substantially worsened in individuals with immuno-metabolic disease. We therefore propose a multidisciplinary research-training programme with an overall objective to uncover cell-specific aspects of tribbles-mediated control of immuno-metabolism and their impact on prostate cancer progression. We will approach this by integrating cell biology and sophisticated in vivo models of both immuno-metabolic disease and prostate cancer, complemented by specialist human disease biobanks, cutting-edge genomics approaches, plus a drug discovery pipeline. This will be carried out by an alliance of leading academic research groups and specialist SMEs with complementary backgrounds in inflammation, adipose tissue biology, tumourigenesis, genomics, translational models of human disease, medicinal chemistry and drug discovery. This will provide a unique opportunity for a cohort of PhD students to undertake Research Training at the interface of several disciplines and sectors, thereby gaining a diverse portfolio of R&D expertise and transferrable skills as well as exposure to several non-academic career pathways.

Keywords: tribbles,adipose,immunity,tregs,macrophages,prostate cancer