Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Auctions with Investments: Timing and Information (AUCTIONS AND INVEST.)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Auctions are important and widely used trading mechanisms. Bidders often undertake investments in relation to an auction they participate in. For example, firms may invest in research and development prior to bidding for public procurement in order to reduce their costs or improve the quality of the goods and services they are offering. The main objective of the proposed research project is to further understand bidders’ incentives for these types of investments and how these incentives interact with the auction rules, and the consequences in terms of efficiency and the seller’s revenue (or the cost of procurement). This understanding will have both theoretical and practical implications in terms of auction design. The project will also be a contribution to the endogenous entry literature. One of the distinguishing features of the project in comparison to the previous literature is allowing firms to have private information at the time of investment, which is quite natural, as firms know more about their own profitability than their competitors. Second, the question of the timing of investments will be addressed, since firms can invest after as well as before the auction. Finally, the issue of observability of investments (at the auction stage) will be tackled. In this general framework, it will be possible to study the firms’ incentives to invest and investigate the performance of commonly used auction formats in terms of efficiency and the revenue of the seller under various specifications. In addition, optimal auctions will be studied using the mechanism design approach. The proposed research project is theoretical. It also aims to help future empirical studies of investments and entry in auctions. It will also be of interest to policy makers, given that auctions are commonly used in government procurement and in selling public assets, and that investment opportunities are ubiquitous in these settings.

Keywords: microeconomic theory,information economics,auctions,investment,r&d,endogenous entry,procurement
Nanoscale Operation and Dynamics of small GTPases - Identification of novel Isoform specifying Determinants (NANODYGP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Small GTPases of the Ras superfamily, a major class of signalling proteins, control critical cellular functions, such as proliferation, differentiation, migration and trafficking. Their misregulation is associated with severe diseases, such as cancer or neurodegenerative diseases. More than 150 Ras-like GTPase are known, which are divided into four major subfamilies, each containing between 22 to 63 structurally related, but functionally distinct isoforms. A fundamental unresolved biological question in the field is the structure-based mechanism, which guides isoform specific functions. Recently, we provided new structural insight on how Ras operates in the context of the membrane. We showed that Ras adopts isoform specific orientations on the membrane, which in turn critically regulate Ras activity. These orientations are guided by a new switch III region and are stabilized by the amphipathic helix α4 and the membrane anchoring, C-terminal HyperVariable Region (HVR). Intriguingly, these structural elements vary from one isoform to another also in other subfamilies, suggesting that this mechanism is also operative in them. We will therefore study, whether this mechanism that involves helix α4 and the HVR also define isoforms of the Rho- and Rab-subfamily. In parallel, we will investigate the molecular mechanisms that are relevant for the overall membrane organisation of GTPases. This includes studies on the dynamics of the orientation, as well as on the mechanism of the formation of nanoscale assemblies (nanoclusters) of GTPases on the membrane. We expect that our results have the potential to substantially transform the current understanding of GTPase functioning and answer a long-standing fundamental biological question. Moreover, both mechanisms represent new, specific targets for pharmacological interventions.

Keywords: small gtpase,nanocluster,structure,ras,fret,single molecule,sted,fcs,signal transduction
System level modelling of metastasis from signalling to cell motility (METASTASIS SYS MOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-12-07
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The most intriguing phenomenon in cancer research is the ability of tumour cells to spontaneously migrate away from the primary tumour and metastasize. Metastases are strongly related to poor prognosis and reduced patient survival. Therefore, studying motility properties of cancer cells may benefit the development of therapeutic methods, and can hopefully contribute to improved survival. Cancer cell motility is achieved by motility structures such as lamellipodia, filopodia and blebs. Blebs are large, round deformations of the cell, mostly driven by hydrostatic pressure that involve changes in the actomyosin cortex. While the mechanical process of bleb formation and retraction is pretty much known, its dependence on internal and external signalling is still missing. In this research we focus on the relations between signalling, blebbing and cell migration, using both experimental data and system-level modelling. The Met tyrosine kinase is an endogenous receptor that normally initiates directional motion, needed for various homeostatic tasks such as embryogenesis and wound healing. High levels of Met were shown to be related to malignancy and metastases. In the proposed research we will study Met amplifications and activating mutations, and their influence on cell shape, motility, tumourigenesis and metastasis, both in vitro and in vivo, using advanced imaging modalities. The experimental results will be used to construct a mathematical model. which couples membrane signalling to actual membrane protruding forces such as hydrostatic pressure and cortical tension, and to the overall cell motion. This allows us to learn how directional motion is achieved by apparently random blebbing and how they are both connected to cellular signalling. This model can also be used to test and predict the effects of different genetic, epigenetic and environmental conditions on the cell’s shape and motility, and will hopefully advance new strategies in metastasis prevention.

Keywords: medical microbiology,systems biology,biophysics
Establishment of a Research and Training Centre in Urban Security and Facility Management (URBAN CRIMINOLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-10-01
End date: 2014-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This ERG will be used to establish a new Centre for Urban Security and Facility Management in the Department of Building and Environment at Danube University Krems (A). The Centre will be a multi-disciplinary knowledge hub at the interface of urban sociology, criminology, real estate and facility management, which will be unique in European academia. The new Centre for Urban Security and Facility Management will be conceived as a research & training site founded on three pillars: Research, education and innovation will be integrated in an approach that follows the concept of “Crime Prevention through Environmental Design (CPTED)”. With special emphasis on crime opportunity structures, research will support a human-centred understanding of crime prevention. In a holistic approach physical, infrastructural and social conditions in combination with management of the built environment are studied with the aim to contribute to the knowledge transfer between practitioners in the building professions, security management and science. Social Area Analyses will help understand the conditions for public order, Crime Hot Spot Analysis will study opportunities for crime in urban space, and studies on private policing in shopping centres will help understand new cultures of control in mass private properties. Crowd monitoring will be used as an instrument to study correlations between crowding and security. Together these research fields will reinforce an innovative approach to crime prevention that looks beyond punitive strategies and blind trust in security technology, but takes into account conditions in the built environment to avoid opportunities for crime, while at the same time designing attractive places in urban structures. Insights from these core fields of research will provide the basis for a certified Masters Programme that will be developed in an international consortium for practitioners and stakeholders who study at the University for Continuous Education.

Keywords: social sciences,crime prevention through environmental design,research and training centre,architecture,facility management,criminology
Femto- and attosecond imaging of molecular multiple ionization: Time-resolved electron and nuclear dynamics using free electron lasers and ultra-short pulses (ATTOTREND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2015-02-22
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The advent of ultrafast laser technology in the xuv and x-ray domains, by means of free-electron lasers and high harmonic generation, has opened the path to novel experiments at femto and attosecond time scales with direct applications on Chemistry and Atomic and Molecular Physics. These advances allow one to track in real time ultrafast electronic and nuclear dynamics induced by electromagnetic radiation. This largely unknown dynamics is at the focus of the proposal. Interpretation of ultrafast time-resolved experiments necessarily involves state-of-the-art time-dependent theoretical methods, together with advanced supercomputing resources. This remains a challenge due to the computational difficulty to include all electronic and vibrational degrees of freedom and the added complexity related to a multi-body Coulomb break up problem. ATTOTREND aims to develop a new theoretical tool based on time-dependent ab initio methods to account for the full dimensionality of the problem. Numerical methods combined with recently developed techniques to extract information from time-propagated wave-packets will be implemented. In particular, we seek to perform the first ever ab initio calculations on multiphoton double ionization of the hydrogen molecule including the dissociative channel. The second aim of this proposal is to carry out XUV attosecond pump-probe studies on molecules leading to single and double ionization. Double ionization processes are ideal to explore electron correlation and dynamics, and therefore to acquire a deeper knowledge of the basic mechanisms that governs the physics arising at the attosecond time scale. Finally, by combining these time-dependent methods with existing quantum chemistry tools, ATTOTREND also aims to explore these processes on more complex molecules of chemical interest.

Keywords: physical sciences,atomic and molecular physcis,double ionization,ultra-short xuv pulses,free electron lasers,molecular ionization,electron dynamics
DOT/MRI Dual-Modality Cancer Imaging Using a Bifunctional Contrast Agent (UNLU_IRG2010)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

New exogenous molecular probes have been used in the optical imaging field. We have already developed a multi-frequency & multispectral optical tomography animal imaging system. The system has been integrated to a magnetic resonance imaging (MRI) system. In this project, we will expand our hybrid system to measure dynamic information from exogenous probes. This system would measure the enhancement kinetics of the bi-functional optical/MR or mono-functional optical contrast agents and the endogenous contrast due to hemoglobin contents and scattering properties. There are two parts of the proposal. In the first part, we will development a novel multi-modality dynamic imaging system. Inthe second part, we will develop polymer based bi-functional and mono-functional optical agents. Such a hybrid system would facilitate the development of new contrast agents for biomedical imaging and that the development of polymer based molecular agents will provide a potential new molecular platform for these new contrast agents. At the end of this project, we will be able to test our hypothesis that “the parameters obtained bymacromolecular optical agent together with total hemoglobin, oxygen saturation and tissue scattering parameters can achieve a higher specificity in differentiating between ENU induced malignant and benign tumors compared to MRI parameters measured by low molecular weight extracellular MRI agents”.

Keywords: biomedical engineering,computational physics
Dispersal and Speciation in Micrometazoans. Geographic Barriers, Phylogeography and Phylogeny in Limnoterrestrial Tardigrades (DSM.GBPP.LT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2012-12-31
Duration (months): 27.0
Total project cost (EUR): 33750.0
EU funding (EUR): 33750.0
Participants: 1
Project status: CLOSED

Micrometazoans could be an intermediate status, in terms of speciation process, between larger animals (above 2 mm), because they have multicelullar conditions, and unicellular organisms, since they share habitats, resources, small size, and some biological aspects. Morphological and molecular information, needed for speciation approaches, are complementary data for population genetic, biodiversity and phylogenetic analyses among different taxonomic levels. The “Everything is Everywhere” hypothesis assumed for unicellular organisms to have wider distributions than larger animals, and more restricted distributions are explained by environmental selection, being historical events irrelevant (opposite to larger animals where are explained by historical together with ecological events). We will test speciation processes hypothesis (such as Everything is Everywhere) in micrometazoans studying Tardigrada phylum. Tardigrades are multicellular organisms phylogenetically closely related with larger animals, but with microscopic sizes (under 2 mm even hydrated/active forms), dormant stages easily dispersed, and high population numbers (like unicellular organisms). We will study patterns and processes in two environments (terrestrial and freshwater) with different dispersal ways, ecological conditions and habitat patch connections to understand speciation in Tardigrada. We will analyze with morphological and molecular information: (1) genetic populations of wide distributed species in both slopes of ancient mountains (older than tardigrade fossil record) in central Iberian Peninsula and at different elevation points along rivers within the area, (2) biodiversity patterns related with environmental, phylogenetic and taxonomic features, (3) influence of geographic barriers on population genetic structure and biodiversity patterns, and (4) phylogenetic relationships at high taxonomic levels (needed for lower taxonomic levels) since its lack of information for tardigrades.

Keywords: biodiversity,evolutionary biology,phylogeny,population genetics,taxonomy,systematic zoology
Light assisted single electron manipulation (LASEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The aim of this project is to develop new technique that allows single electron manipulation by the light. The novelty of the project is to take advantage of the unique capabilities of carbon nanotubes for single electron detection to study electronic properties of various types of molecular systems subjected to external light source. To do this a novel nanodevice layout consisting of the carbon nanotube (CNT) combined with quantum dots or molecules is proposed. In the device layout the CNT is acting as a ultra-sensitive detector for single electron detection and the quantum dot is attached to only one electrode – a nanotube. Two configurations of the device layout are proposed. In the first scenario the nanotube and the probed molecule are laying on an insulating oxide surface and in second scenario the device is suspended. This layout overcomes problem seen in standard devices where a molecular system is placed between two electrodes and very often it turns out that it is impossible to pass any measurable current through the system. Detection scheme is based on the fact that electrons can tunnel between the quantum dot and the tube detector. Electron transport between these nanoobjects will be controlled by light illumination and it will be detected by means of electron counting spectroscopy technique. The proposed idea represents a new strategy to study the separation in energy between the electronic discrete levels of the quantum systems subjected to the light illumination. Another aim of the project would be to investigate the effect of light on the transport properties of molecules that can undergo structural and electronic modification upon light exposure. Upon light exposure some molecules can undergo a process that results in change of the shape of the molecule. This will modify the molecule-tube tunnel barrier in the device. Light can also change the separation between energy levels of the molecule. Both cases can be monitored by proposed technique.

Keywords: experimental physics,nanoelectronics,electron-based nano-devices,optoelectronics,carbon nanotubes,quantum transport,quantum dots,molecular electronics,single electron detection
Planning cultures in the USA and in Germany in comparison - the example of shrinking cities (PLANSHRINKING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Current debates show a rising awareness that several cities in Europe and the US have to deal with challenges of long-term demographic and economic changes leading to urban shrinkage associated with housing vacancies, underused infrastructure and other negative impacts. On an international scale, it is still not clear if or in what way planning paradigms, planning systems, planning strategies, and planning cultures are adapting when faced with urban shrinkage. Bridging both the US and European discussion on planning cultures by means of an evidence-based comparative research work is a new and innovative approach in spatial research. In this context the following two aims and respective research questions will be investigated: 1. Identify paradigm shifts, and possible changes in planning systems and planning cultures in view of shrinking cities in Germany and the USA (Which assumptions and values regarding planning have changed or have been adjusted?, What are the options for a shrinking city? ) 2. Develop a toolset to evaluate planning strategies for shrinking cites (Which requirements for future oriented planning from the international comparison can be utilized for shrinking cities?, What are major benchmarks for the perception of shrinkage, which could be utilized as an early warning system?). The project makes use of an embedded case study approach. This will facilitate in-depth investigations of the stakeholders involved in shrinking cities - their motivations, actions, and the limits they are confronted with. Four case studies will be selected: two cities from Germany, and two cities from the USA. In order to provide the basis of a comparative analysis, two analytical approaches of planning systems will be synthesized: the culturized planning model (Knieling and Othengrafen, 2009), and a typology of planning strategies (Pallagst, 2007).

Keywords: urban and regional development,shrinking cities,planning cultures