Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mems based Appliance for GYro Compassing in general aviation and unmanned aircraft applications (MAGYCO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-07-01
End date: 2017-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the future the demand for air traffic services will increase and will shift towards more unscheduled operations for air taxi, charter, fractional ownership, and on-demand small low-cost aircraft (A/C). Many players of the aviation community are planning to make significant investments in the specific Communication, Navigation and Surveillance (CNS) systems improvements over the next years, in order to enhance efficiency, safety, capacity and security. Inertial Systems, core component of CNS systems, are used to measure the attitude of an A/C with respect to local reference frame (heading, pitch, roll angles) and are composed by a set of inertial sensors called gyros and accelerometers. The existing commercial solutions perform aiding through non-inertial sensors, usually magnetometers, which can suffer from external interference that produce non-nominal performance in terms of accuracy. For pitch and roll angles self-initialization can be effectively realized by exploiting accelerometer measurement. Regarding the heading term, it can be estimated by sensing the local horizontal component of Earth Rate using gyros. This self-initialization technique is called “gyrocompassing” or “northfinding”, since the function of the compass is performed by gyros. Earth Rate is in the order of 15°/hour. As a consequence, very accurate gyros must be adopted. Recently, the development of miniaturized vibratory gyros, such as Micro Electro Mechanical Sensors (MEMS), allowed to attain a bias instability levels better than 1°/hour. However, this limit does not ensure that initial heading is determined with accuracy in the range 1°-0.1° (1σ). MAGYCO project aims at the development of an innovative aerospace grade Inertial Unit based on miniaturized vibratory gyros with autonomous northfinding capabilities that can be used to improve the overall navigation capabilities of General Aviation (GA) aircraft and Unmanned Aircraft Vehicles (UAV) at affordable costs for the manufacturers.

Keywords: inertial system,navigation system,mems,northfinding,gyrocompassing,general aviation,unmanned aircraft,cns system,magnetometers,gyros,accelerometers
A lab-on-chip platform for blood cell counting and identification at the point-of-care (pocL-CI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Greece
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-07-01
End date: 2017-12-31
Duration (months): 18.0
Total project cost (EUR): 148250.0
EU funding (EUR): 148250.0
Participants: 1
Project status: CLOSED

Blood cell counting/identification is the most powerful and widespread approach throughout the world for assessing an individual’s health status. The diagnosis and monitoring of an infection (e.g. HIV, malaria, bacterial infection), the monitor of a chemotherapy outcome (e.g. in cancer patients) or even the diagnosis of rare diseases (e.g. sickle cell disease, non-Hodgkin lymphomas), relies on analysing the number and/or the morphology of different types of blood cells. Here, we aim to validate a portable, single-cell counting/identification platform that can be used to diagnose and monitor diseases at the point-of-care. The platform consists of a low-cost, handheld, battery-operated, scanner and a disposable microfluidic biochip. The underlying technology, termed ‘Label-free Cell Identification (L-CI) technology’, is based on the integration of novel, microfabricated components that enable to simultaneously image and count thousands of cells at high spatial resolution. If successfully commercialized, the L-CI platform will be the first medical instrument to perform a blood cell counting test by the end user at home, in few minutes. The potential is enormous as the L-CI platform will replace millions of blood cell tests that routinely performed by trained personnel in clinics and hospitals in the developed world but it will also make blood cell tests available in the developing wold.

Keywords: lab on chip,microfluidics,cell counting
Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections (GLYCOSWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1994117.5
EU funding (EUR): 1994117.0
Participants: 1
Project status: SIGNED

Glycans are directly involved in the normal physiology and in the etiology of several major diseases, spanning from bacterial and viral infections through to cancer and autoimmune disorders. Thus, deciphering the glycome holds huge promise to provide new targets and diagnostics for human health. Despite the tremendous advance of knowledge in the field of Glycoscience during the last decade, the comprehension at high resolution of the molecular basis of many pathogen-mediated diseases is still incomplete. GLYCOSWITCH will significantly contribute to fill this gap, providing a holistic picture of the manifold mechanisms of host responses to microbial infections, with a special focus on Gram-negative bacteria. I propose to address bacterial glycans recognition by host immune proteins by using a multidisciplinary approach, combining state-of-the-art synthetic organic chemistry, molecular biology, biochemistry and biophysics techniques, massively including NMR spectroscopy. I will apply them in an innovative integrated chemical biology approach in order to decipher key glycan recognition aspects beyond current knowledge. Understanding of molecular mechanisms of detection of invasive virulent bacteria by host organisms will allow to reach the ultimate goal of GLYCOSWITCH project: the design and development of novel and effective glycomimetics able to modulate the function of host immune receptor proteins. The success of GLYCOSWITCH will unlock attractive opportunities for the development of host-directed strategies to boost the immune response or reverse pathogen-induced immunosuppression. My unique approach to this project, as an organic chemist with wide expertise in NMR and bacterial glycans, will provide groundbreaking information on protein-glycan interaction systems of paramount importance in biology and biomedicine, opening new avenues for approaching bacterial diseases and their secondary effects.

Keywords: structural glycoscience,molecular recognition,host pathogen interactions
Quantum sensing of two-dimensional magnets (QS2DM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 2317521.0
EU funding (EUR): 2317521.0
Participants: 1
Project status: SIGNED

Van der Waals (vdW) materials are layered compounds that can be readily exfoliated down to the monolayer limit. Magnetic order has recently been observed in such atomic monolayers. This milestone discovery could launch a new era in nano-magnetism, in, which the exceptional cleanliness and tunability of these truly two-dimensional magnets may enable fundamental discoveries and novel technologies based on atomic-scale functional magnetic elements. Direct, quantitative sensing of nanoscale properties of these systems is a key ingredient for further progress. My group has recently demonstrated their power through the first nanoscale imaging of magnetism in atomic-scale vdW magnets. This major advance was enabled by quantitative, nanoscale magnetometry with a single spin - a unique quantum technology, which I have pioneered. I propose to leverage this progress to bring groundbreaking advances to the field of vdW magnetism. Non-collinear, engineered spin textures, such as Skyrmions of helimagnetism, offer a current frontier that I will address, with possibly far-reaching impact for the field of spintronics. I will further harness the high-frequency sensing capabilities of our quantum sensors to address microwave-domain spin-waves in vdW magnets. This completely uncharted domain offers insight into still poorly understood spin interactions and has technological potential through the field of "vdW magnonics", which I plan to establish. This challenging project combines advanced materials engineering with an emerging, and highly promising quantum sensing technology. It is thereby highly interdisciplinary and goes well beyond the state-of-the-art in the fields of vdW magnetism and quantum-sensing. I will thereby further strengthen Europe's position at the forefront of these flourishing research areas. My project requires a commitment of several years, a team of two graduate students and two postdoctoral fellows, and significant investment in instrumentation.

Keywords: 2d magnetism,van der waals crystals,spin textures,magnons,quantum sensing,nanoscale magnetometry
Discrete Groups and Geometric Structures (DiGGeS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2023-12-31
Duration (months): 76.0
Total project cost (EUR): 1049182.0
EU funding (EUR): 1049182.0
Participants: 1
Project status: SIGNED

Discrete subgroups of Lie groups, whose study originated in Fuchsian differential equations and crystallography at the end of the 19th century, are the basis of a large aspect of modern geometry. They are the object of fundamental theories such as Teichmüller theory, Kleinian groups, rigidity theories for lattices, homogeneous dynamics, and most recently Higher Teichmüller theory. They are closely related to the notion of a geometric structure on a manifold, which has played a crucial role in geometry since Thurston. In summary, discrete subgroups are a meeting point of geometry with Lie theory, differential equations, complex analysis, ergodic theory, representation theory, algebraic geometry, number theory, and mathematical physics, and these fascinating interactions make the subject extremely rich. In real rank one, important classes of discrete subgroups of semisimple Lie groups are known for their good geometric, topological, and dynamical properties, such as convex cocompact or geometrically finite subgroups. In higher real rank, discrete groups beyond lattices remain quite mysterious. The goal of the project is to work towards a classification of discrete subgroups of semisimple Lie groups in higher real rank, from two complementary points of view. The first is actions on Riemannian symmetric spaces and their boundaries: important recent developments, in particular in the theory of Anosov representations, give hope to identify a number of meaningful classes of discrete groups which generalise in various ways the notions of convex cocompactness and geometric finiteness. The second point of view is actions on pseudo-Riemannian symmetric spaces: some very interesting geometric examples are now well understood, and recent links with the first point of view give hope to transfer progress from one side to the other. We expect powerful applications, both to the construction of proper actions on affine spaces and to the spectral theory of pseudo-Riemannian manifolds

Keywords: discrete subgroups of lie groups
Transformational uses of dye Plants on Linear B tablets. New approaches to cultural identity and technologies in the Bronze Age Aegean (Trans-PLANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-08-08
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

At the cutting-edge of the scientific scene for their being the first written attestations from Europe, Bronze Age Aegean scripts are crucial to define the linguistic roots of Europe. To achieve this, Linear B is the key area to analyse since it is the only Aegean script embedding elements of different cultures and origins. My research takes on the first systematic study of Bronze Age Aegean cultural identities by way of a very telling case study: processes transforming dyeing plants into finished goods (dyed textiles and perfumes). My aim is to show how the knowledge coming from the transformational uses of dyeing plants transcends how the final product is perceived visually to address what is being communicated culturally. Also, this study will provide ground-breaking information for the history of dyeing processes and bring new data to the use of natural and renewable resources, one of today’s most relevant and timely challenges. It will also implement studies on gender by examining the social construction of gender identities through dyed goods. This project will bring together Mycenaean studies and Indo-European linguistic perspectives and methods, material culture studies and Aegean epigraphy expertise, experimental textile archaeological knowledge and ancient technologies awareness to develop new understandings of linguistic and cultural interactions. I will complete this project in a leading multi-disciplinary research team, with solid scientific expertise and a worldwide network in the topics involved. I will bring philological and linguistic skills that will facilitate research in the group and the transfer of ideas. The proposed work will expand my experience, research competencies, and professional networks. The training and the knowledge transfer as well as the new soft skills I will acquire will be the winning combination for achieving the goals of my project and enhancing the development of my career as an independent researcher.

Keywords: mycenaean,indo european,linguistics,etymology,bronze age,aegean epigraphy,textile,dyes plants,ancient technologies and perfumes,experimental archaeology,archaeobotany,material culture
Advanced Tools and Research Strategies for Parasite Control in European farmed fish (ParaFishControl)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Spain,Italy,Spain,Ireland,Germany,Norway,Norway,Greece,Greece,Croatia,Hungary,Greece,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Scientific basis and tools for preventing and mitigating parasitic diseases of European farmed fish (H2020-SFS-2014-2, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 8104133.75
EU funding (EUR): 7800000.0
Participants: 31
Project status: CLOSED

European aquaculture production provides direct employment to 80,000 people and a 3-billion € annual turnover. Parasites cause severe disease outbreaks and high economic losses in finfish aquaculture. The overarching goal of ParaFishControl is to increase the sustainability and competitiveness of European Aquaculture by improving understanding of fish-parasite interactions and by developing innovative solutions and tools for the prevention, control and mitigation of the major parasites affecting Atlantic salmon, rainbow trout, common carp, European sea bass, gilthead sea bream and turbot. To achieve these objectives, ParaFishControl brings together a multidisciplinary consortium comprising 28 partners possessing world-leading, complementary, cross-cutting expertise and drawn from public and private research organisations, and the aquaculture industry. The consortium has access to excellent research facilities, diverse biological resources including host-parasite models, and state-of-the-art vaccinology, genomic, proteomic and transcriptomic technologies. The project will: 1) generate new scientific knowledge on key fish parasites, including genomics, life-cycle, invasion strategy and host-parasite interaction data, with special emphasis on host immunity, pathogen virulence and immunomodulation, providing a scientific basis for improved prophylaxis; 2) determine the transfer of parasites between farmed and wild host populations; 3) develop a wide range of novel prophylactic measures, including vaccines and functional feeds; 4) provide a range of advanced or alternative treatments for parasitic diseases; 5) develop cost-effective, specific and sensitive diagnostic tools for key parasitic diseases; 6) assess the risk factors involved in the emergence, transmission and pathogenesis of parasitic diseases; 7) map the zoonotic risks due to fish helminths and; 8) provide a catalogue of good husbandry practices to obtain safe and high-quality fish products.

Keywords: teleostei,host parasite interactions,immunology,food safety,vaccination,protistans,metazoans,diagnostic kits,epidemiology,integrated pest management strategies,food security,sustainability
Multi-scale analysis of the interplay between cell morphology and cell-cell signaling (MorphoNotch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Signaling, genetic regulatory circuits, and tissue morphology are inherently coupled to each other during embryonic development. Although changes in cellular and tissue morphology are commonly treated as a downstream consequence of cell fate decision processes, there are multiple examples where morphological changes occur concurrently with the differentiation processes. This suggests that a feedback between cell morphology and regulatory processes can play an important role in coordinating tissue development. Currently, however, we lack the experimental, theoretical, and conceptual tools to understand this interplay between cell morphology, signaling, and regulatory circuits. In particular, we need to understand (1) how intercellular signaling depends on the cellular morphology and on the properties of the boundary between cells, and (2) how intercellular signaling, genetic circuits, and cell morphology integrate to generate robust differentiation patterns. Here, I propose to combine quantitative in-vitro and in-vivo experiments with mathematical modeling to address these questions in the context of Notch signaling and Notch mediated patterning, typically used for coordinating differentiation between neighboring cells during development. We will utilize novel reporters and micropatterning technology to analyze Notch signaling between pairs of cells. We will elucidate how the geometry and the molecular composition of the boundary between cells affect signaling. At the tissue level, we will study how the interplay between cell morphology and Notch signaling gives rise to robust patterning in the mammalian inner ear. We will use cochlear inner ear explant imaging to track the transition from disordered undifferentiated state to ordered pattern of hair and supporting cells in the cochlea. Together with a novel hybrid modeling approach, we will provide the foundation for a systems level understanding of development that interconnects morphology and regulatory circuits.

Keywords: notch signaling,inner ear,cell morphology,developmental patterning
Sexual Selection and Sleep in Arctic Shorebirds (SSIAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-15
End date: 2023-02-14
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

What is the best way to attract and pursue a mate? This question is central for understanding how animal behaviour evolves through sexual selection. In the arctic, some male shorebirds almost entirely forgo sleep during the breeding season, and males that sleep least have the most offspring. These findings defy our understanding of the importance of sleep for optimal performance. So which specific behaviours are key to the success of these birds? Here, we propose using state-of-the-art accelerometers and machine learning models, together with conventional field methods, to explore how behaviour affects reproductive success in arctic shorebirds. Specifically, we will investigate whether the duration and frequency of courtship and territorial behaviours predicts number of offspring, and whether these behaviours vary with time spent awake. This unique research will focus on two species: polygynous pectoral sandpipers and sex-role-reversed red phalaropes. The research will combine the supervisor’s well-established methods for studying arctic shorebirds, the supervisor’s expertise in sexual selection, the researcher’s experience collecting and analysing large accelerometry datasets, and the researcher’s expertise in avian sleep. The proposed research will have four key implications. First, it will reveal whether overall time spent active is most important for reproductive success, as implied by previous research in pectoral sandpipers, or whether specific behaviours are key. Second, it will examine how extreme sleep loss relates to behaviour in wild birds, which might offer insights into sleep’s functions. Third, it will elucidate the behavioural strategies of males and females in a novel sex-role-reversed mating system, and compare these with a polygynous species in the same environment. Finally, the research will test the extent to which accelerometry can distinguish behaviour in a natural context, which has broader value for behavioural research.

Keywords: sexual selection,reproductive success,fitness,ornithology,sleep,mating systems,courtship,activity,accelerometry,competition,arctic,sex role reversal,rhythms,data loggers,performance