Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Recentering Friction Floor Dissipater for Resilient-based Design of Steel Structures (RFFD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-03-29
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

In regions of moderate and high seismicity such as Europe, steel concentrically braced frames (CBFs) are considered a cost-effective lateral force resisting system to withstand seismic and/or wind loading. Comprehensive building-specific economic loss assessment suggests that the expected annual losses of steel CBF buildings are mainly associated with repairs of acceleration-sensitive building components, which in turn results into building functionality disruption after an earthquake. Higher building vibration mode effects and the complex asymmetric inelastic behaviour of steel braces make it challenging to prevent soft-storey mechanisms that potentially lead to global collapse even in capacity-designed steel CBF buildings. The proposed project aims to address the aforementioned issues by developing an innovative dissipation device, named Recentring Friction Floor Dissipator (RFFD) to control the earthquake-induced vibration and demands in steel CBF buildings through its diaphragm response instead of the lateral load resisting system that is traditionally attempted. This will minimize the variability of the inertia force demands along with the earthquake-induced life-cycle costs. The device realization will be achieved through physics-based computational simulation-based design validated to full-scale testing. Macro-models will be developed to facilitate, for the first time, time-dependent nonlinear building simulations that will be benchmarked to a landmark system-level experiment. A graphics-based design tool will be developed that will combine in a single format economic loss metrics with multiple building performance indicators to aid decision-making for enhanced building service life in seismic regions. After having acquired extended experience in the field of earthquake engineering in New Zealand and Japan, the applicant wants to reintegrate to Europe to consolidate his career in a leading European University.

Keywords: earthquake engineering
Factories of the Future Resources, Technology, Infrastructure and Services for Simulation and Modelling 2 (Fortissimo 2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Spain,Spain,Italy,Italy,Germany,Spain,Italy,Germany,Germany,Spain,Italy,Italy,Italy,Norway,Belgium,Slovenia,Slovenia,Slovenia,Sweden,Sweden,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: ICT Innovation for Manufacturing SMEs (I4MS) (H2020-FoF-2015, 2015)
Start date: 2015-11-01
End date: 2018-12-31
Duration (months): 38.0
Total project cost (EUR): 11423985.45
EU funding (EUR): 9999775.89
Participants: 40
Project status: CLOSED

Fortissimo 2 will drive the uptake of advanced modelling, simulation and data analytics by European engineering and manufacturing SMEs and mid-caps. Such an uptake will deliver improved design processes, better products and services, and improved competitiveness. For the European Union as a whole this means improved employment opportunities and economic growth. The importance of advanced ICT to the competitiveness of both large and small companies in the engineering and manufacturing domain is well established. Despite early successes in this area, there are still many barriers to the uptake of such solutions, not least of which are the initial cost and complexity of adoption, particularly in the context of challenging trading conditions. This proposal targets the ICT Innovation for Manufacturing SMEs (I4MS) action line (Phase 2) and builds on Phase 1 of that initiative. Phase 2 addresses the adoption of next generation ICT advances in the manufacturing domain. At the core of Fortissimo 2 are three tranches of Application Experiments (~35 in total). An initial set is included in this proposal and two further sets will be obtained through Open Calls for proposals. These experiments will be driven by the requirements of first-time users (predominately SMEs) and will bring together actors from across the value chain, from cycle providers to domain experts via the Fortissimo Marketplace. This will enable innovative solutions to manufacturing challenges, leading to new and improved design processes, products and services. A key feature of Fortissimo 2 will be the adaption of the Marketplace to meet the needs of end-users. It will offer a responsive and reliable service to companies which want to access HPC and Big resources and expertise. Fortissimo 2 initially involves 732 months of effort, a total cost of €11.1m and EC funding of €10m over a duration of three years, commensurate with achieving its ambitious goals.

Keywords: cloud marketplace innovation
Resilience in ant societies (resiliANT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2499969.0
EU funding (EUR): 2499969.0
Participants: 1
Project status: TERMINATED

Complex systems are found at all levels of biological organisation, from molecules to ecosystems. Despite the huge differences in scale, each of them has evolved homeostatic processes conferring resilience to external perturbations. Ants provide an ideal system to identify behavioural responses allowing biological systems to recover from disturbance. The overall aim of this proposal is to identify the collective mechanisms responsible for this resilience. This will be achieved by conducting both abiotic and biotic perturbations. Abiotic perturbations such as flooding frequently have major effects on the demography of the workforce, for example by whipping out all the foragers. We will therefore perform highly controlled perturbations (e.g., targeted removal of worker groups) designed to induce compensatory changes in the behavioural trajectories of the remaining ants to test whether ants can deviate from their baseline behavioural trajectory to mitigate the effect of external perturbations A major biotic challenge faced by all highly social species is the rapid spread of disease between closely-packed conspecifics. Because the kinetics of disease transmission in social groups depends upon the structure of the interaction network, we will investigate how the prophylactic properties of the social interaction network emerge from the individual-level behaviours. Finally, we will perform controlled inoculations with a generalist fungal pathogen to identify active individual-level behavioural responses that further hinder pathogen transmission. The proposed studies which capitalise on two recent methodological advancements (the development of sophisticated network analysis tools and, a tracking system which allows unprecedented collection of behavioural data (e.g., millions of pairwise interactions) will make important contributions to our understanding of processes involved in resilience of complex systems and how animal societies respond to stochastic environments.

Keywords: social behaviour,disease transmission,ants
Making national identity. The construction of Germanic Mythology in 19th century. (MYTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

We are witnessing today a renewed mythologisation of the political sphere: myth has returned to occupy a persuasive and central role in modern political and cultural life, taking on the form of fictional narratives, “false myths” and ideologies, which are dangerously replacing rational debate. The process of demythologization (Entmythologisierung) of religious, political, cultural and social dynamics that began after the Second World War seems to have reached a standstill, revealing the unresolved contradictions inherent to the cult of reason and the Dialectic of Enlightenment. The question of the need for myth in every culture, modern culture not excluded, is still unanswered. Critical awareness of myth and its function as a cultural agent in today’s climate is critical, although the all too obvious demonization of myth should not be supplanted by the facile—and equally mythical—valorization of reason. As Jan Assmann argues, the function of myth in the modern world goes beyond a simple elaboration of the past. Indeed, all mythopoetic activity has immediate productive value and can be characterized as a dominant historical agent. A critical-historical study of the origins and development of the modern concepts of myth and mythology is of capital importance if we are to redefine our categories of thought and understand the pervasive phenomena that have dominated European culture for the last two centuries. My research takes on the first systematic study of mythology by way of a very telling case study: the birth of German Mythology studies. My aim is to show how German intellectuals created a system of Germanic mythology based on materials appropriated from Nordic myth and the model prevalent in European culture at the time: Greco-Roman mythology. This newly established Germanic myth imposed itself as an alternative model to the classical one, providing a new foundation for the construction of nationalistic cultural and political identities.

Keywords: myth,culture,civilisation,national identity,mythology,intellectual history,18th 20th century,germany,grimm,nordic mythology,german mythology,comparativism,ideology
Multivalent Molecular Systems for Innovative Applications (MULTI-APP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Germany,Italy,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2321096.4
EU funding (EUR): 2321096.4
Participants: 9
Project status: CLOSED

This network brings together the major academic players active in Europe on the fundamentals and application of multivalency and cooperativity. The network is complemented by industrial partners ranging in scale from a small spin-off to a large multinational. The main objective of this consortium is to raise a new generation of researchers able to develop complex chemical systems that harness cooperativity for enhanced functional properties. Multivalency is one of Nature’s governing principles for achieving strong and selective biomolecular recognition. Many biological processes rely on the cooperative effects associated with the occurrence of multivalent interactions. Consequently, there is an enormous interest in the development of chemical multivalent systems that display similar features for innovative applications in fields as various as diagnostics, drug discovery, materials science and nanotechnology. The central theme of multivalency and cooperativity is used to connect partners from academia and industry with a common interest in understanding how multivalency works, but for very different scopes and using very different approaches. This network is thus uniquely positioned to train the next generation of European researchers in all multidisciplinary aspects related to multivalency. A broad training program has been developed that comprises top-level individual research projects, both general and specific network-wide dedicated courses, secondments, personalized scientific training and a broad package of complementary skill training. The industrial partners contribute in the form of training, supervision, technical contributions, and perspectives on the commercialisation of multivalent systems. After completion of the program, the ESRs will be the first generation of researchers able to fully exploit the potential of multivalent chemical systems. Their unrivalled career profiles will enable them to compete successfully for positions in academia or industry.

Keywords: multivalency,cooperativity
Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications (BETASCREEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-02-01
End date: 2018-07-31
Duration (months): 18.0
Total project cost (EUR): 149365.0
EU funding (EUR): 149365.0
Participants: 1
Project status: CLOSED

Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant pancreatic islets into the anterior chamber of the eye (ACE) of mice for functional microscopic imaging. In the ACE islets become vascularized and innervated, and various aspects of β-cell function and survival can be readily imaged. Functional studies demonstrate that engrafted islets in the eye serve as representative reporters of endogenous islets in the pancreas of the same animal. We have extensively in vitro tested fluorescent biosensors that reflect key-events in β-cell function and survival. Following intraocular transplantation of human islets expressing biosensors in their β-cells into healthy or diabetic mice, they will allow non-invasive, longitudinal in vivo monitoring of 1) Ca2+ handling, 2) functional β-cell mass, 3) apoptosis and 4) proliferation. Based on the in vitro tested biosensors, the major objective is to establish a robust pharma-industry in vivo platform for validating newly developed diabetes treatment lead-compounds in early drug development. This screening service shall be performed on a commercial basis. The milestone of this proposal, to be achieved within 18 months, is the validation of the in vivo platform for testing the effects of new potential diabetes medicines on human β-cell function and survival in normal and diabetic mice.

Keywords: diabetes mellitus pancreatic beta cell,in vivo imaging,drug screening,fluorescence microscopy
Exploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease (FatTryp)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Portugal
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Background: The study of protozoan pathogens has been extensively explored often motivated to find suitable targets for new intervention strategies. However these studies have been mostly limited to those life-cycle stages that can be cultivated in vitro. Using a mouse model of African trypanosomiasis, we have recently discovered that the adipose tissue (fat) is a major reservoir for the extracellular protozoan Trypanosoma brucei and that, within this environment, parasites become phenotypically different from those in the blood. Our study exposed novel biology of the T. brucei life cycle, yet it remains unknown how parasites adapt to the fat and how parasite fat tropism affects disease. Our first aim is to determine the molecular and cellular mechanisms underlying T. brucei fat tropism. We will perform a genetic screen in mice to identify key parasite genes required for establishing and maintaining chronic infection in the fat. Together with the information of the transcriptome and proteome, we will identify the mechanistic steps underlying parasite tissue-adaptation. Our second aim is to identify the consequences of T. brucei fat tropism for the host and the importance for disease. We will first investigate if parasites can egress from the fat. We will also determine if parasites induce lipid breakdown in the host, leading to loss of fat mass. Finally, we will measure the impact of fat tropism in general traits of disease, including host survival and transmission potential. Impact: This project represents a completely novel research avenue built on recent work from my laboratory. By uncovering fundamental aspects of the biology of T. brucei, we will also improve the understanding of clinically relevant features of African trypanosomiasis, including relapses and weight loss. In addition, since parasite fat tropism has also been observed in malaria and Chagas’ disease, our findings will help elucidate disease mechanisms relevant to other infectious diseases.

Keywords: adipose tissue,gene expression,metabolism,trypanosoma brucei,tropism
Solution sets for the Cost reduction of new Nearly Zero-Energy Buildings - CoNZEBs (CoNZEBs)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Italy,Italy,Germany,Slovenia,Denmark,Denmark
Call: Cost reduction of new Nearly Zero-Energy buildings (H2020-EE-2016-CSA, 2016)
Start date: 2017-06-01
End date: 2019-11-30
Duration (months): 30.0
Total project cost (EUR): 1561651.25
EU funding (EUR): 1561651.25
Participants: 9
Project status: CLOSED

CoNZEBs will identify and assess technology solution sets that lead to significant cost reductions of new Nearly Zero-Energy Buildings. The focus of the project is on multi-family houses. Close cooperation with housing associations allows for an intensive interaction with stakeholders and tenants. The project will start by setting baseline costs for conventional new buildings, currently available NZEBs and buildings that go beyond the NZEB level based on the experience of the consortium. It will analyse planning and construction processes to identify possible cost reductions. An investigation of end-users' experiences and expectations together with a guide on co-benefits of NZEBs will promote living in these buildings and enhance the energy performance by conducive user behaviour. The technology solution sets will include approaches that can reduce costs for installations or generation systems, pre-fabrication and construction acceleration, local low temperature district heating including RES, and many more. Examples are pure electrical heating in combination with PV, PV/T in conjunction with a heat pump so that no earth coupling is required, ventilation supply through the walls to reduce the costs for ducts, larger bricks including insulation, decentral domestic hot water generation (fresh-water stations), etc. All solution sets will be assessed regarding cost savings, energy performance and applicability in multi-family houses. A life cycle assessment of different building levels and NZEBs using the solution sets will provide a longer term perspective. Communication to stakeholders and dissemination of the project results will include events and discussions with the national housing associations. The project consortium is comprised of the leading national research organisations in the field of high performance buildings in 4 countries incl. the core theme leaders of the Concerted Action EPBD working areas “Nearly Zero-Energy Buildings” and “Cost-optimal levels”.

Keywords: nzeb,cost reduction,multi family houses,solution sets,end user,processes
Smart Industrial innovation as enabler to drive new value chains for textiles and aerospace (GALACTICA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Italy,Spain,Spain,Greece,Belgium,France,Portugal
Call: Cluster facilitated projects for new industrial value chains (H2020-INNOSUP-2019-01-two-stage, 2019)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 4999848.75
EU funding (EUR): 4999848.75
Participants: 10
Project status: CLOSED

GALACTICA aims to bring Europe to the forefront of textile and aerospace GALACTICA aims to support the creation of new industrial value chains around textile and aerospace based on advanced manufacturing across EU to throttle growth and employment of the future by the development of long-term internationally competitive goods and services that require combining different competences and innovative solutions. This way, GALACTICA will empower Industrial intelligent systems or Industrial Internet of Things as part of the strategic alignment with President Juncker priorities on strategic emerging value chains for Europe towards 2030 as outcome of the High-level industrial roundtable. GALACTICA’s strategy is: 1. Cultivation within an open collaboration space focused on supporting SMEs to change the mindset about digitalization and empower them to start partnerships. 2. A set of dedicated grants complemented with coaching to assess the feasibility and small technical tests aimed at minimum viable products of a new value chain. 3. Large scale demo of the new value chain with dedicated grant for SME consortia with coaching and technological support. 4. Scale-up support to leverage additional funds. GALACTICA will connect successful SMEs with private investors and other initiatives for scaling up the innovations. In total, 4M€ (79% of budget) will be dedicated to SMEs through diverse vouchers to support technological innovation and value chain creation. New value chains will find synergies with RIS3 policies through partners’ active participation in different S3 Thematic platforms on industrial modernization and S3 Vanguard Initiative pilots (3DP, ESM and RegioTex). GALACTICA partnership will allow to reach directly (as cluster members) 1.400 SMEs, 170 large companies and over 200 research facilities across 8 EU-countries, and indirectly over 7.000 SMEs across 38+ countries though EU-wide networks and European Strategic Cluster Partnerships.

Keywords: advanced manufacturing,textile,aerospace,new value chains,cross sectoral,cross border,innovation management,smart industry,industrial iot,cluster,ris3,vanguard initiative