Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nutrient sensing by parasites (PARASITENUTRISENSING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Portugal
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-12-01
End date: 2017-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its metabolism. Our preliminary data provides unequivocal evidence that Plasmodium has the ability to sense the host low-nutrient status and adapt to it by decreasing its multiplication rate. Thus, the overall goal of the present proposal is to unveil the molecular mechanisms by which parasites are capable to sense and adapt to environmental signals originated from nutrients and to determine its impact on the course and virulence of infection. To that end we propose to: (i) Identify Plasmodium pathway(s) that sense (host) nutritional changes; (ii) Uncover which molecules are sensed by Plasmodium during its intracellular development; (iii) Study the impact of the parasite’s nutrient sensing pathways activity on the course of infection; and (iv) Evaluate host nutritional status sensing as a common feature in parasites. The present proposal moves towards a change of paradigm on how host-parasite interactions are viewed. By definition, since a parasite requires a host in order to survive, a decrease in the availability of an essential molecule obtained from the host will weaken the parasite and render it incapable of succeeding in its life cycle. The rationale behind this proposal is that parasites monitor host nutritional environment and, prior to any nutrient(s) becoming limiting, are able to respond and adapt to the sensed alteration(s). Multidisciplinary approaches that combine genetic, genomic, cell biological and physiological methodologies will be used. Results arising from the present proposal will provide novel insights into the cell biology of these parasites and will increase our understanding of the interactions that these parasites maintain with their hosts.

Keywords: nutrient sensing,parasites,plasmodium,malaria,trypanosoma,host-parasite interactions,sirtuins,ampk,tor,glucose sensing,virulence.
Lab-in-a-tube and Nanorobotic biosensors (LT-NRBS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Germany,Germany
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1499880.0
EU funding (EUR): 1499880.0
Participants: 3
Project status: CLOSED

The goal of this project is to develop new types of biosensors based on two different approaches: (i) a new bioanalytic microsystem platform for cell growth, manipulation and analysis using on-chip integrated microtubes and (ii) the use of synthetic self-propelled nanomotors for bioanalytical and biosensing applications. Based on the novel “Lab-in-a-tube” concept, we will design a multifunctional device for the capturing, growth and sensing of single cell behaviours inside “glass” microtubes to be employed for diverse biological applications. We will decorate the walls of the microtubes with proteins from the extracellular matrix enabling the long-term study of cellular changes such as mitosis time, spindle reorientation, DNA damage and cellular differentiation. These microtubes are fabricated by the well-established rolled-up nanotechnology developed in the host institution. Moreover, the multifunctionality of the “Lab-in-a-tube” platform will be extended by integrating different modules into a single microtubular unit, bringing up several applications such as optofluidics(bio)sensors, electrodes for electrochemical control and sensing, and magnetic biodetection. At the IIN institute in IFW Dresden, we are pioneers on the fabrication of catalytic microjet engines (microbots) and their use for transporting different kinds of objects in vitro into a fluid. The remote controlled motion of these autonomous microbots and the transport of microobjects and cells to specific targets within lab-on-a-chip systems is possible. Their walls can be biofunctionalized with enzymes, antibodies or DNA, the catalytic microbots representing a novel and unique tool for biosensing, environmental and biomedical applications. Our next step is to use biocompatible fuels to propel these microbots with the final aim of transporting and delivering drugs in vivo.The separation of cancer cells, bacteria and other biomaterials to build up new tissues or to replace disease cells are also aimed.

Keywords: micromotors,lab-on-a-chip
Electrochemical LEctin and glycan biochips integrated with NAnostructures (ELENA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Slovakia
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1155970.0
EU funding (EUR): 1155970.0
Participants: 1
Project status: CLOSED

Glycomics is currently one of the most progressively evolving scientific fields due to ever growing evidence glycans (sugars) are involved in many aspects of cell physiology and pathology. Glycans are information-rich molecules responsible for sophisticated storage and coding “commands” the cell has to perform to stay “fit” and to deal with uninvited pathogens. Thus, it is very important the “glycocode” is correctly deciphered by the cell to stay healthy, but pathogens developed nasty tricks how to crack the “glycocode“ to their benefit by stealing glycan identity of the host to stay unrecognised until it is too late. A better understanding of these processes can help to develop new, potent and nature-based vaccines and drugs. Glycomics stayed behind advances in genomics and proteomics, but due to advent of high-throughput biochips glycomics is catching up very quickly. Two biochip formats available to study challenging and complex field of glycomics are either based on immobilised glycans (glycan biochips) or glycan recognising molecules – lectins (lectin biochips). Both technologies proved to be a success story to reveal amazing, precisely tuned “glycocode” reading, but so far biochips do not work under conditions resembling natural process of glycan deciphering. The aim of the project is to develop biochips for fundamental study of the effect of precisely tuned ligand (glycan and lectin) density, presence of mixed glycans and the length of glycans on the glycan biorecognition. This task will be executed with the aid of nanotechnology to control these aspects at the nanoscale. Moreover, novel label-free electrochemical detection strategies will be used to mimic natural glycan recognition performing without any label. Finally, advanced patterning protocols and novel detection platforms will be integrated to develop fully robust biochips for functional assay of samples from people having some disease with a search for a particular biomarker of the disease.

Keywords: electrochemistry,nanotechnology,nanoparticles,carbon nanotubes,graphene,self-assembled monolayers,lectin biochips,glycan biochips,glycomics
Mechanisms of homeostatic plasticity in the intact mouse visual cortex (HOMEOSTASIS_IN_VIVO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2018-12-31
Duration (months): 72.0
Total project cost (EUR): 1494473.93
EU funding (EUR): 1494473.93
Participants: 2
Project status: CLOSED

Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeostatic mechanisms in the intact mouse visual cortex following sensory deprivation. We will use this paradigm together with chronic two-photon imaging of synaptic structures and function, via genetically encoded calcium indicators in awake behaving animals. These techniques allow us to measure the structure and function from the same synapses and cells over a period of weeks to months, both before and after sensory deprivation. In the work proposed here, we will investigate two basic principles of homeostatic plasticity: 1) the spatial scale at which homeostatic mechanisms occur – is it at the level of individual dendrites or are all changes implemented cell-wide? and 2) the relationship between homeostatic plasticity and the degree of changing activity levels in cells and networks of cells – is the degree of resulting homeostatic plasticity dependent on the level of deprivation? If so, can changes in dendritic activity, cellular activity or network activity drive these changes? We will investigate these questions for both excitatory and inhibitory neurons in the intact mouse visual cortex for two forms of homeostatic plasticity – synaptic scaling and the balance between excitation and inhibition.
Genetic and Epigenetic Determinants of Paget's Disease of bone (GENEPAD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-10-01
End date: 2018-03-31
Duration (months): 66.0
Total project cost (EUR): 1493543.6
EU funding (EUR): 1493543.6
Participants: 1
Project status: CLOSED

Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are responsible for ~10% of PDB cases with high penetrance. We have recently identified seven additional susceptibility loci for PDB using genome-wide association studies (Albagha et al, 2011; Nat Genet). These recently identified loci have a combined effect that explained about 13% of familial risk suggesting that other genetic factors remain to be identified. The aims of this project are three fold: 1) to define the functional variants in the recently identified susceptibility loci using targeted DNA sequencing, 2) To identify novel genetic variants for disease susceptibility using exome sequencing in PDB patients without SQSTM1 mutations, 3) To investigate the role of epigenetic factors and their interaction with genetic factors in the pathogenesis of PDB. We will study genome-wide DNA methylation patterns in PDB patients and controls to identify differentially methylated sites associated with PDB. The contribution of epigenetic factors to the focal nature of PDB will be studied using an animal model of PDB to assess if epigenetic changes are specific to bone lesions and to determine if these changes contribute to disease development or occur as a consequence of the disease. Identification of genetic and epigenetic factors that predispose to PDB will increase our understanding of disease mechanisms and could also identify novel molecular pathways that could form targets for new therapeutic treatment not only for Paget’s disease, but also other diseases associated with increased bone turnover. These factors could be used as markers for disease susceptibility to assess people at risk of developing PDB later in life and target those with the highest risk for early treatment.

Keywords: disease,bone
Elucidating early pathogenic mechanisms of neurodegeneration in Parkinson's disease through a humanized dynamic in vitro model (PD-HUMMODEL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Spain
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-07-01
End date: 2019-06-30
Duration (months): 72.0
Total project cost (EUR): 1324802.0
EU funding (EUR): 1324802.0
Participants: 1
Project status: CLOSED

Our understanding of Parkinson’s disease (PD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic, most frequent, form of PD. It may be possible to overcome these challenges by reprogramming somatic cells from patients into induced pluripotent stem cells (iPSC). In preliminary studies, we have generated a collection of 50 iPSC lines representing both sporadic PD and familial PD patients, and identified distinct PD-related neurodegeneration phenotypes arising, upon long-term culture, in DAn differentiated from these PD-iPSC. Here, I propose to take advantage of this genuinely human PD model to investigate: i) mechanistic insights responsible for the PD phenotype identified in our model (by combining molecular and biochemical analyses to study mitochondrial function and redox profile, as well as genome-wide transcriptional profile of control versus PD-patient specific iPSC-derived DAn); ii) early functional alterations in patient-specific iPSC-derived DAn, which would predate neurodegeneration signs and provide valuable information as to ways to prevent, rather than rescue, neurodegeneration in PD patients (by electrophysiological recordings in in vitro reconstructed neuronal/glial networks to assess synaptic dynamics together with neuronal excitability); iii) further refinements in our iPSC-based PD model, including the generation of iPSC lines representing asymptomatic patients carrying pathogenic mutations, and the correction of known mutations by gene edition, all of which will allow exploring the relationship between pathogenic mutations and the genetic makeup of patients; and iv) whether DAn degeneration in PD is solely a cell-autonomous phenomenon, or whether it is influenced by an altered cross-talk between DAn and glial cells. These studies may impact significantly on our understanding of PD pathogenesis and on the development of new therapy strategy.

Keywords: parkinson's disease,ips cells,in vitro model
Mediterranean Science, Policy, Research & Innovation Gateway (MED-SPRING)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Bi-regional coordination of S&T cooperation including priority setting and definition of S&T cooperation policies
Action type: Coordination and support actions
Countries involved: Italy,Egypt,Spain,France,Germany,Italy,Greece,Malta,Portugal,Cyprus,Türkiye,Morocco,Algeria,Tunisia,Jordan,Israel,Palestine, State of,Lebanon,France,Belgium,Italy
Call:  (FP7-INCO-2012-1, 2012)
Start date: 2013-02-01
End date: 2017-07-31
Duration (months): 54.0
Total project cost (EUR): 4480222.0
EU funding (EUR): 3999944.85
Participants: 29
Project status: CLOSED

The main aim of the Project is to contribute to the quality of the Euro-Mediterranean research area, with a particular focus on the bi-regional Euro-Mediterranean S&T cooperation, research & innovation, policy dialogue and cooperation monitoring. The proposal aims at tackling the key issues and policy objectives outlined in the Work Programme by creating a dialogue and coordination platform of governmental institutions, research organizations, associations and NGOs helping integrate society in the institutional dialogue. To this end, the Project foresees a comprehensive analysis of selected societal challenges and will address capacity building to increase research capacity, shared knowledge and cooperation. It will also support synergies and networking to strengthen joint activities and EU- MS-MPCs cooperation in EU programmes, as well as a monitoring of regional RTD cooperation and policies. In particular, the proposal is structured to address three societal challenges: energy, high quality affordable food, scarcity of resources. These challenges have been selected on the basis of the result of the long-standing and ongoing EU-MPCs policy dialogue and represent the most significant areas of common interest in current Euro-Mediterranean cooperation. The specific objectives of the Project are thus: enhancing EU-MPCs co-ownership in research cooperation; creating synergies in order to reduce fragmentation of research actions; involving the civil society in the institutional dialogue on research and innovation; developing cooperation instruments to tackle societal challenges with a view to sustainability; supporting research and innovation capacity building through comprehensive training and contributing build an Euro-Mediterranean shared knowledge space in order to develop common EU-MPCs planning capacity and a sustainable regional RDT policy and cooperation.

Keywords: research and innovation policy,euro-mediterranean resarch cooperation,rtd dialogue,food,energy,scarcity of resouces
Advancement of the bilateral Partnership in scientific Research and Innovation with the Russian Federation (BILAT-RUS-ADVANCED)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Bilateral coordination for the enhancement and development of S&T Partnerships
Action type: Coordination and support actions
Countries involved: Germany,Russian Federation,France,Austria,Greece,France,Germany
Call:  (FP7-INCO-2012-2, 2012)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 1787511.85
EU funding (EUR): 1497798.0
Participants: 17
Project status: CLOSED

The overall strategy of BILAT-RUS 2 puts the three main issues of the Capacities work programme into practice. It will provide input for the EU-Commission on the state of EU-Russian STI cooperation; contribute to coordinate research policies and programmes of European Member States, Associated Countries and the EU-Commission; enhance information collection and dissemination as regards STI between Russia and the EU; raise awareness of researchers in Russia and the EU for cooperation potentials; monitor the existing STI cooperation praxis and facilitate the implementation of a sustainable cooperation support system; analyse the Russian innovation system and provide support for enhanced implementation of R&D results; deliver a feasibility study for a common representation of European scientific institutions in Russia. One of the major success factors is the close continuous dialogue and the coordination of activities with Russian and European authorities, addressing in particular the Ministry of Education and Science of the Russian Federation (MON), responsible Ministries/Agencies in EU Member States and the EU Commission. The individual activities and tasks that are proposed in the work packages of the project cover a wide array of activities. They include general information and awareness raising activities, the maintenance of the established web-portal with data and knowledge bases on STI issues as well as a inventory and analysis of existing cooperation instruments, the preparation of three yearly analytical reports on the state of EU-Russian STI cooperation, the publication of guidelines for better implementation of R&D results, a feasibility study for a common representation of European scientific organisations in Russia, as well as a mobility grant scheme. Also, activities include the establishment of an external quality control body and an Advisory Board.

Keywords: support for eu-russian sti policy dialogue,coordination of research policies and programmes of european ms and the eu-commission towards russia,analysis and support for the russian innovation system
Protecting the health of Europeans by improving methods for the detection of pathogens in drinking water and water used in food preparation (AQUAVALENS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: United Kingdom,Spain,Germany,United Kingdom,Denmark,Sweden,United Kingdom,France,Germany,Portugal,Ireland,Iceland,Spain,United Kingdom,Austria,Germany,Italy,Finland,United Kingdom,Serbia,Germany,United Kingdom,United Kingdom,Switzerland,Spain,Austria,Denmark,Ireland,Denmark,United Kingdom,Netherlands
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 11909166.46
EU funding (EUR): 8963425.0
Participants: 43
Project status: CLOSED

The AQUAVALENS consortium has brought together SMEs, Industries, Universities and Research Institutes with the mission of protecting the health of European Citizens from contaminated drinking water and water used in food processing. We will achieve this by developing sustainable technologies to enable water system managers whether in large or small water systems or within food growers or manufacturers to better control the safety of their water supplies. The work of the project is divided into four main clusters of work packages that sequentially lead to the development of appropriate technologies. These four clusters are: 1. Platform targets, 2. Platform development, 3. Field studies in European drinking water systems, and 4. Improving Public Health through safer water. In cluster 1 we shall generate new knowledge on the molecular genetics of viral, bacterial and parasitic waterborne pathogens. This will enable us to identify gene targets for the identification, and characterisation of these pathogens, that will also enable the determination of their virulence for humans. In cluster 2 we shall use the knowledge gained to develop new technologies that integrate sample preparation and detection into a single platform. These platforms will then be subject to a rigorous process of validation and standardisation. In cluster 3 we will use the validated platforms to undertake a series of field studies in large and small drinking water systems, and in food production. These field studies will generate new knowledge about the risk to public health from waterborne pathogens in Europe and also test the value of the technologies in the field. Finally in cluster 4 we test how these technologies can be used to protect human health, though improving the effectiveness of Water Safety Plans, adaptation to climate change, and control of outbreaks of infectious disease. We will also determine the sustainability and potential economic impacts of these technologies.

Keywords: waterborne pathogens,water safety plans,sensors,integrated platforms,climate change,sustainable,source tracking,virulence,gene targets,food production,water treatment