Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the role of scleral events on a novel treatment for Myopia using microscopy techniques (MYOMICRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-16
End date: 2023-09-15
Duration (months): 36.0
Total project cost (EUR): 263732.16
EU funding (EUR): 263732.16
Participants: 2
Project status: CLOSED

Myopia prevalence has increased dramatically in the last few decades. It has reached 30% among young population in Europe and U.S.A. and over 80% in Asia. However, refractive correction remains the only option for treatment. Myopia has been linked to the shifting balance between far- and near-vision activities and the resulting abnormal axial growth of the eye, but many key questions remain unanswered, which are critical for exploring new treatments. The goal of my research is to advance our understanding of myopic eyes and help to develop new treatments for myopia. As an important step, I propose to develop new innovative optical instruments with which we can characterize myopic eyes in unprecedented details to gain novel insights, and also to assess treatment effects objectively and comprehensively beyond conventional vision tests. Specifically, I aim to accomplish the following: (a) substantial advances in the understanding of physical changes underlying myopia, (b) quantitative assessment of optical, structural, and mechanical properties of the eye during myopia development, and (c) anatomical- and structural-level assessment of novel interventions to stop myopia progression. The applicant will lead this proposed project, termed MYOMICRO, as a collaborative project between the EU beneficiary (VioBio Lab, CSIC, Spain), and the partner organization (Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, USA). A short research stay (Visual Sciences group, University of Newcastle, Australia) in a secondary partner organization is included. The outcome of this project will enhance the EU leading position in vision care.

Keywords: myopia,microscopy,second harmonic generation,brillouin,adaptive optics,sclera,cross linking,animal eye model
A sensor-equipped seat cushion to support office workers and teach a healthy lifestyle depending on physiological signals gathered unobtrusively. (SitSmart)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 102500.0
EU funding (EUR): 102500.0
Participants: 1
Project status: CLOSED

Sedentary posture at work is very common for office workers throughout the world. This creates a major health risk that may lead to organ damage, muscle degeneration, or back problems. SitSmart - a sensor-equipped seat cushion detects various physiological signals to break the cycle for customers interested in this self-assessment.

Keywords: lifestyle change,workplace,sensor cushion,coaching
Smart Integration of Energy Storages in Local Multi Energy Systems for maximising the Share of Renewables in Europe’s Energy Mix (SmILES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: New knowledge and technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Belgium,Belgium,France,Denmark
Call: European Common Research and Innovation Agendas (ECRIAs) in support of the implementation of the SET Action Plan (H2020-LCE-2016-ERA, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 2440682.5
EU funding (EUR): 2440682.5
Participants: 7
Project status: CLOSED

SmILES zooms in simulation and optimisation of smart storage in local energy systems for increasing the understanding and transparency of innovative multi-energy projects. Setting up a shared data and information platform and effective dissemination of related results will contribute to competence building. The objective is to obtain fundamental knowledge about linking and optimising heterogeneous energy carriers and systems including storage and renewable energy technologies from local to national level. Furthermore guidelines for modelling and optimising such systems on European level are developed. These guidelines are derived from knowledge of different energy system configurations (SC), which combine heat and electrical power with storage. The SCs are selected to favour a high relevance for replication throughout Europe including e.g. urban quarters, rural township or industrial environment. This requires the development of a harmonised rich format describing hybrid energy systems and study cases for various scenarios. Different technologies are used to exchange models, allow cross-checks and validate results of simulation and optimisation. A catalogue of best practices of modelling, operating and integrating multi-energy systems is compiled and intended to serve as guideline for stakeholders. Key success factors and barriers from a socio-technical point of view are identified aiming at the reduction of technological gaps and successful implementation of best practices in a socio-economic context. Thus, SmILES will proof the benefit of a hybrid combined heat- and electrical power systems with storage capabilities and deploy the added value of storage integration in future energy systems. Supplementing the research activities, a long-lasting framework across EERA JP borders is set up by the consortium for extending storage integration technologies by linking other EERA members, stakeholders, energy supplier and industry.

Keywords: storage integration,hybrid energy systems,renewables
Systematic Design and Testing of Advanced Rotating Packed Bed Processes and Phase-Change Solvents for Intensified Post-Combustion CO2 Capture (ROLINCAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Korea, Republic of,Greece,Greece,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: International Cooperation with South Korea on new generation high-efficiency capture processes (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 3212587.5
EU funding (EUR): 3089845.0
Participants: 12
Project status: CLOSED

ROLINCAP will search, identify and test novel phase-change solvents, including aqueous and non-aqueous options, as well as phase-change packed bed and Rotating Packed Bed processes for post-combustion CO2 capture. These are high-potential technologies, still in their infancy, with initial evidence pointing to regeneration energy requirements below 2.0 GJ/ton CO2 and considerable reduction of the equipment size, several times compared to conventional processes . These goals will be approached through a holistic decision making framework consisting of methods for modeling and design that have the potential for real breakthroughs in CO2 capture research. The tools proposed in ROLINCAP will cover a vast space of solvent and process options going far beyond the capabilities of existing simulators. ROLINCAP follows a radically new path by proposing one predictive modelling framework, in the form of the SAFT-γ equation of state, for both physical and chemical equilibrium, for a wide range of phase behaviours and of molecular structures. The envisaged thermodynamic model will be used in optimization-based Computer-aided Molecular Design of phase-change solvents in order to identify options beyond the very few previously identified phase-change solvents. Advanced process design approaches will be used for the development of highly intensified Rotating Packed Bed processes. Phase-change solvents will be considered with respect to their economic and operability RPB process characteristics. The sustainability of both the new solvents and the packed-bed and RPB processes will be investigated considering holistic Life Cycle Assessment analysis and Safety Health and Environmental Hazard assessment. Selected phase-change solvents, new RPB column concepts and packing materials will be tested at TRL 4 and 5 pilot plants. Software in the form of a new SAFT-γ equation of state will be tested at TRL 5 in the gPROMS process simulator.

Keywords: solvents,rotating packed beds,absorption desorption,process design
Data-driven decision making for a more efficient society (BiggerDecisions)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Estonia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-03-31
Duration (months): 19.0
Total project cost (EUR): 1830625.0
EU funding (EUR): 1281437.0
Participants: 1
Project status: CLOSED

The rapid diffusion of digital information technologies has created an explosive growth in the amount of digital data. 90% of the world’s data today has been created in the last two years alone. The availability of this data has opened up an opportunity to create significant value on all levels of the society. More extensive use of this data for data-driven decision-making (by companies, governments, researchers) could improve European GDP by more than €120 billion by 2020. However, this opportunity is currently restricted by privacy regulations, distrust and business secrets. Sharemind is the first technology that truly enables the use of confidential data for data-driven decision-making, and thereby fundamentally enhances the potential value of big data. The novelty of Sharemind lies in its ability to extract useful information from private data without even seeing the data. Sharemind makes new types and more data available for sharing/analysis and simplifies the data analysis process, and thereby enables applications that have been impossible before. Users of Sharemind gain new insights that can be used for making decisions, improving productivity, optimising marketing, developing new products and services and implementing new business models. Sharemind has been validated in an operational environment with five piloting customers (TRL7). Our go-to-market action plan foresees approaching our existing list of interested prospects as soon as the limitations to Sharemind global scale-up have been removed in the BiggerDecisions project. We have identified 250 customer leads, of which 30 are currently in sales negotiations with us. One of the main factors supporting our commercialization efforts is the enforcement of General Data Protection Regulation in 2018, requiring a level of data privacy and security that is beyond what most organisations are currently equipped to manage. We will execute a business strategy yielding over €94 million in revenues in 2021.

Keywords: big data,cybersecurity,privacy,gdpr,analytics,counter fraud,location data,personal medicine
Efficient and connected rain-gun sprinkler irrigator (ELEKTRORAIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Despite sprinkler automated irrigation has made significant breakthroughs at the time, irrigation still face several and important challenges as: 1) Field’s obstacles as electricity pylons, buildings, rocks etc. 2) Irregular field shapes 3) Field corners/borders, making the farmer use fixed sprinklers to irrigate this area, 4) Wrong irrigation speed. All together provoke a big water loss of more than the 25% of the fresh water needed (depending on the crop and field size), an increase of the irrigation time of the 30%, (depending on the flow and speed) and as a consequence, the increase of the carbon foot print that this extra time provokes, as the motor pumps are powered by the fuel. This can be translated into thousand litres of freshwater lost and hours from farmer/operator time, as a continuous sprinkler supervision is needed. SIME Idromeccanica SRL, a company located at the Reggio Emilia region in Italy, with more than 50 years’ experience regarding irrigation systems, developed ELEKTRORAIN: a unique travelling rain-gun irrigation system avoiding a water loss of the 25%, and a reduction of the time needed of the 30%. ELEKTRORAIN is provided with a programable and attached control mechanism able to provide a more uniform irrigation changing the speed and angle overcoming water loss in borders/corners and avoiding obstacles and different field shapes/sizes without manually adjusting the gun. Sprinkler irrigation systems market is projected to reach € 2.4 billion by 2025, from € 2.1 billion in 2019, at a CAGR of 2% during the forecast period. Also, the European agricultural sector is responsible for about 24 % of the global water use. Hence, the Micro-irrigation System market in the region is expected to continue to grow to 14.06% CAGR over the forecast period of 2019-2027

Keywords: field irrigation,raingun,farming,agriculture,water depletion
Dissecting and leveraging glucagon-like peptide-1 brain pathways in obesity (Ob_GLP1)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Obesity is a major health challenge in the EU and globally, and yet the best drug therapies achieve only modest reductions in weight loss and require life-long treatment. To prevent and treat obesity it is crucial we understand the neural pathways controlling appetite and how they can be ‘hijacked’ therapeutically. The brain glucagon-like peptide-1 (GLP1) system is a promising target. GLP1 receptor agonists (GLP1RAs) decrease food intake and bodyweight in obese patients, effects which are mediated by two brain regions: the arcuate nucleus of the hypothalamus (Arc) and the nucleus of the solitary tract (NTS). This project, Ob_GLP1, combines the neuroscience background of Dr Holt with the next-generation technology and imaging expertise of Dr Hodson to test the hypothesis that obesity disrupts the function of GLP1RA-responsive Arc and NTS circuits and that obesity can be rescued by selectively targeting intracellular signalling in GLP1RA-activated neurons. This hypothesis will be tested through the completion of four independent, yet complementary work packages. Work package 1-3 will determine the effect of obesity on 1) GLP1RA access to the Arc and NTS measured using fluorescently labelled GLP1R antagonist and whole-brain light-sheet microscopy; 2) the molecular distribution and oligomerisation state of GLP1Rs in the Arc and NTS; and 3) the innervation pattern and synaptic density of Arc and NTS GLP1R neurons. Work package 4 will assess the potential of a novel GLP1-conjugated antisense nucleotide as an effective anti-obesity treatment. Ob_GLP1 will advance our knowledge of the brain’s control over obesity, while allowing Dr Holt to reintegrate into the European research environment and will facilitate substantial two-way transfer of knowledge between the host lab and Dr Holt, ultimately benefitting both parties, as well as society as a whole.

Keywords: obesity,metabolism,neuroanatomy,appetite,feeding
Holographic 3D Display for visualising volumetric images from medical scanners (HoloMedical3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2015-12-01
End date: 2018-08-31
Duration (months): 33.0
Total project cost (EUR): 1286812.5
EU funding (EUR): 900768.75
Participants: 1
Project status: CLOSED

Medical imaging technology has been improving at a rapid pace over the past decades with Ultrasound, CT, PET and MRI scanners increasing in performance. This is driven by the need to deliver faster, high quality, efficient and cost-effective healthcare. These machines generate 3D volumetric imagery as a series of 2D slices scanned through the body using radiation (ionising & non-ionising) or ultrasound. These data are presented directly to viewer(s) as full 3D images via the holographic volumetric display. The display essentially performs the inverse operation and converts the radiation into a photonic representation, showing the 2D slices as a series of “light sheets” suspended in free space. Holoxica has pioneered a series of motion holographic video displays over the past few years. The award-winning technology produces excellent results with large, bright images floating in mid-air without the need for cumbersome glasses. The display system comprises state of the art optical components (patented Holographic Optical Element, lasers, high speed projection), embedded electronics and image processing with software. The basic principles have been proven (TRL4/5) in a series of national projects and successful completion of the project will result in a TRL7 prototype validated within realistic medical scenarios. The benefits of the holographic volumetric display include quicker interpretation of 3D scan images, faster surgery and better quality surgical procedures. The breakthrough innovation will meet an urgent demand from medical professionals for a 3D visualisation solution that can match the performance of scanning devices. Applications include teaching/training, diagnostics/planning and live surgery. Medical Imaging 3D Displays is a global $4.3B market by 2020, growing at 42.2% CAGR. This disruptive innovation may be used across many other multi-billion euro industries including airport security, computer monitors and consumer TV or video gaming.

Keywords: holography 3d display imaging optics photonics
Unlocking the hidden information in char to create a new quantitative toolkit for use in forensic fire investigations (FORCHAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-11-01
End date: 2022-03-31
Duration (months): 29.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Fire Investigations are undertaken to determine the origin and cause of fires in housing or commercial properties, to identify whether there may be a need for criminal investigation, to provide information on financial loss and in the case of loss of life to design protocols to protect society. Charring is one of the most obvious products of fire and fire investigators have long attempted to utilise patterns of charring to determine fire origin and cause. However, these have often had to rely on qualitative descriptions of charring as there is no quantitative tool that allows them to measure the degree of charring of wood materials. My ERC StG developed a quantitative method that allows the amount of light reflected from charcoals to be measured toward estimating wildfire behaviour. In FORCHAR (forensic char) I aim to adapt this approach and develop it into an essential tool for use in the fire investigator’s forensic toolkit. Its strength is that it allows quantitative measurements of char properties to be used to interpret the origin and source of fires. The FORCHAR tool will be taken through a series of phases of validation testing to that 1) will provide proof of concept that the approach can be transferred from wildfires to fires in the built environment, 2) will allow real-world testing where FORCHAR will be utilised in real fire scene investigations via collaborations with industry partners. The aim being to develop a new tool that can be used to improving fire safety protocols toward preventing the loss of life.

Keywords: fire investigation,forensic science,charring,charcoal,fire damage,fire patterns,fire effects
Ultra Low emission Technology Innovations for Mid-century Aircraft Turbine Engines (ULTIMATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Greece,Sweden,France,France,United Kingdom,United Kingdom
Call: Breakthrough innovation for European Aviation (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 3138121.88
EU funding (EUR): 3138121.88
Participants: 10
Project status: CLOSED

With the ULTIMATE project five experienced research groups and four major European engine manufacturers will develop innovative propulsion systems to fulfill the SRIA 2050 key challenges. One of the most challenging targets is the 75% reduction in energy consumption and CO2-emissions. Technologies currently at TRL 3-5, cannot achieve this aim. It is estimated that around a 30% reduction must come from radical innovations now being at lower TRL. Thus, European industry needs synergetic breakthrough technologies for every part of the air transport system, including the airframe, propulsion and power. The ULTIMATE project singles out the major loss sources in a state of the art turbofan (combustor irreversibility, core exhaust heat, bypass exhaust kinetic energy). These are then used to categorize breakthrough technologies (e.g. piston topping, intercooling & exhaust heat exchangers, and advanced propulsor & integration concepts). This classification approach gives a structured way to combine and explore synergies between the technologies in the search for ultralow CO2, NOx and noise emissions. The most promising combinations of radical technologies will then be developed for a short range European and a long range intercontinental advanced tube and wing aircraft. Through the EU projects VITAL, NEWAC, DREAM, LEMCOTEC, E-BREAK and ENOVAL, the ULTIMATE partners have gained the most comprehensive experience in Europe on conception and evaluation of advanced aero engine architectures. Existing tools, knowledge and models will be used to perform optimization and evaluation against the SRIA targets to mature the technologies to TRL 2. Road maps will be set up to outline the steps to develop the technologies into products and bring them onto the market. These road maps will also provide a way forward for future European propulsion and aviation research.

Keywords: radical powerplant technology