Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative and efficient solution, based on modular, versatile, smart process units for energy and resource flexibility in highly energy intensive processes (CIRMET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Italy,Belgium,Belgium,Poland,France,France,Netherlands
Call: Energy and resource flexibility in highly energy intensive industries (IA 50%) (H2020-NMBP-SPIRE-2018, 2018)
Start date: 2018-10-01
End date: 2022-12-31
Duration (months): 51.0
Total project cost (EUR): 9884901.98
EU funding (EUR): 7012782.85
Participants: 18
Project status: CLOSED

The project aims to design, develop and validate an innovative solution, the CIRMET solution, to provide energy and resource flexibility to Energy Intensive Industries (EIIs) The CIRMET solution will be validated in an operational environment (TRL7) in an existing process plant (non-ferrous sector) while the replicability of the solution will be assessed in three additional energy intensive sectors (steel, cement and water sector). For this purpose, three new demonstrators will be build up, plus the retrofitting of existing industry process unit. The new demonstrators or modules will be: EFFIMELT furnace, a new concept of flexible and modular process unit for industrial wastes treatment, RECUWASTE heat recovery unit, for flue gas heat recovery and transformation into compressed air to re-used in the same plant, having also the possibility of storing the excess energy and AFF40 (Analytic For Factory 4.0) platform, to improve process plant competitiveness, to increase energy and resource efficiency by controlling and optimizing process units. The retrofitting of an existing process unit (Metallo S.L process furnace) will be done to implement and validate the complete CIRMET solution. A well-balanced consortium formed by academia, research organization, SMEs and energy intensive industries ensures the whole value chain needed to achieve project objectives and paves the way for future exploitation of the solution. The effective dissemination of project outcomes to the current and next generation of citizen and employees through the development of learning resources with flexible usage to be carried out by education/training experts within the consortium is eventually also an important objective of the consortium.

Keywords: energy and resource flexibility,valorization of industrial wastes,metallurgy furnace,heat recovery system,advanced control
Deciphering the crosstalk between cancer stem cells-tumor microenvironment and therapeutic implications in intrahepatic cholangiocarcinoma (SteMiCCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Intrahepatic cholangiocarcinoma (iCCA) is the second primary malignancy of the liver with few therapeutic options, late diagnosis, chemotherapy resistance and dismal prognosis. iCCA incidence and mortality increased worldwide in the last decades, linked to the rise of risk factors including non-alcoholic steatohepatitis. iCCA is a highly heterogeneous tumor characterized by a complex and dynamic tumor microenvironment (TME) where stromal cells coexist with cancer and cancer stem cells (CSC). CSCs are a heterogeneous subpopulation of cancer cells capable of tumor initiation, malignant growth and responsible for chemoresistance. The main objective of the “SteMiCCA” project is to identify and target the unexplored CSC-TME interactions in iCCA, aimed to better understand the complex biology and to identify new therapeutic targets for this deadly disease. To achieve this objective, an interdisciplinary approach including in vitro (spheroids and organoids from human and mouse) and in vivo (ICC-models, subcutaneous and xenograft tumor induction) systems; high throughput transcriptomics (scRNA-Seq and RNA-Seq) and bioinformatics will be employed. Considering my strong background and experience in iCCA and TME, and the host institution’s well-recognized expertise in stem cell biology and liver cell plasticity, this proposal envisions a successful reciprocal transfer of knowledge. Moreover, this fellowship will allow me to gain expertise in supervision, intellectual property management, research funding and proposal writing, with the main goal to acquire more competences and reach professional maturity to start my own research line in iCCA. This will also be a first step to strengthen my network and start contributing to European actions such as ESCALON PROJECT 825510 and EURO-CHOLANGIO-NET, created to boost multidisciplinary studies with interest in basic, translational and clinical research in the field of CCA.

Keywords: intrahepatic cholangiocarcinoma,cancer stem cell,tumor microenvironment,cell heterogeneity,ligand receptor interaction,chemoresistance,target therapy
Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans (HITCHIPDIAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 147094.0
EU funding (EUR): 147094.0
Participants: 1
Project status: CLOSED

Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans Heparin, a complex glycosaminoglycan (GAG) carbohydrate, is the most commonly used anticoagulant. Twelve million patients in the EU are treated annually for conditions including acute coronary syndrome, deep-vein thrombosis and cardiopulmonary bypass surgery. Heparin-induced thrombocytopenia (HIT) is a dangerous adverse side effect of heparin administration. HIT-II develops after major surgery or dialysis and results in infarction, multi-organ failure and 20% mortality. In Europe 100,000 patients develop HIT-II annually. Currently, two HIT-II diagnostics are available. The HIPA and MAIPA tests detect antibodies against a complex of heparin and platelet factor 4 but suffer from low diagnostic specificity and accuracy. Faster, more reliable and cheaper methods to diagnose complications after administration of heparin are needed to improve patient wellbeing and reduce costs. The ERC Advanced grant AUTOHEPARIN yielded an instrument for the automated assembly of defined oligosaccharides. GAG glycan microarrays were produced by printing GAG oligosaccharides onto surfaces and used to screen patient blood. Specific glycan markers of high diagnostic value were discovered to detected HIT-II within minutes and reliabilities well above existing tests. The overall goal of the project is to establish the business model for a company that will focus on the production of GAG glycan arrays as HIT diagnostic. Specific activities include: 1) Development of standard protocols to detect HIT-II using GAG glycan microarray; 2) Plan and cost structure for GAG arrays production; 3) Analysis of the IP space and development of an IP strategy; 4) Evaluate potential markets and establish basis for commercial discussion with potential customers; 5) Prepare business plan for discussions with investors; 6) Incorporate company to commercialize GAG arrays as HIT diagnostic

Keywords: glycan arrays,heparin,oligosaccharides,diagnostic,automated synthesis,glycosaminoglycans
Cerebellar Spiking Model For Real-time Closed-loop Sensorimotor Control (SpikeControl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

Understanding how the brain processes and represents information is at the core of experimental studies of the Central Nervous System (CNS). A network of brain subsystems mediates information processing through distributed neural computation and dynamic patterns of neural activity. Over the last decades, studying how these patterns are elicited in the CNS under specific behavioural tasks has become a break through research topic in integrative neuroscience. These specific tasks are related to the concept of embodied cognition, according to which the primary goal of the CNS is to solve and facilitate the body-environment interaction. This project focuses on the cerebellum, a brain region that plays a crucial role in body-environment interaction, with a primary function related to adaptive motor control and coordination. The functional characteristics of the cerebellum make it a perfect candidate to start modelling and building an embodied nervous system. The cerebellar capability of performing adaptive information processing mediating sensorimotor control will be evaluated in specific tasks. Additionally, the emergence of cognitive-like representations will be studied by focusing on how models of the environment/tools can be acquired through a closed-loop sensorimotor interaction. This project sets forth a multidisciplinary methodology combining neuromimetic models and embodied neurorobotics. Simulated neural models and robotic experiments will guarantee full access to the system properties, which will be assessed through both qualitative and quantitative performance indicators to facilitate a constructive cross-validation against neurophysiological data. This approach will also allow us to predict new functional roles of specific cell/network/topology properties. The goal of this project lies on moving forward the knowledge frontiers in integrative neuroscience and biological control, thus boosting the candidate position at the cutting-edge of these fields.

Keywords: spiking cerebellar models,light weight robot,spike timing dependent plasticity,distributed plasticity,embody neuroscience,real time sensorimotor control,neurorobotics
Static and Dynamic Decision Making under Uncertainty: Theory and Applications (SDDM-TEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 667875.0
EU funding (EUR): 667875.0
Participants: 1
Project status: CLOSED

Everyday actions involve an amount of uncertainty in the final outcome they will deliver. Following Knight's view, some of this uncertainty is “measurable” (Risk) while some of it is “not measurable” (Ambiguity). In Economics, understanding agents’ behavior under uncertainty is of fundamental importance. For many years, and in both contexts, the standard model of decision making has been the Expected Utility model. Since the famous thought experiments of Allais and Ellsberg, many alternative approaches and departures from Expected Utility were proposed. Our research agenda has two main goals. First, we aim to show how different approaches and concepts in Decision Theory are connected to each other: namely, incompleteness of preferences, violations of Independence, preference for randomization, the certainty effect, and random choice. Economists have long understood the relevance of these behavioral phenomena, and more and more models are now including them in applications, for example in Macroeconomics and Finance. A deeper understanding of these phenomena and of their relationship would significantly benefit research in several fields of Economics. More practically, it will help in developing comprehensive models in which these biases are linked to each other benefiting more applied research. Second, decision theorists have studied Ambiguity mostly in static (atemporal) contexts that are insufficient for the analysis of the steady state and dynamic decision problems that characterize applications. Thus, for example, as a result, Macro-Finance mostly keeps relying on traditional decision models that cannot properly cope with model uncertainty. We intend to develop a general theory of recursive intertemporal preference models under uncertainty to address this important issue. We expect that the novel theoretical findings of our research agenda will push the research frontier and will be relevant for the analysis of the role of uncertainty in several fields.

Keywords: risk,ambiguity,random choice,incomplete preferences,recursive preferences,certainty effect
NANOmaterials: STRategies for Safety Assessments in advanced Integrated Circuits Manufacturing (NanoStreeM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Ireland,Ireland,Germany,Ireland,Italy,Germany,Belgium,Belgium,France,France,Netherlands,Netherlands
Call: Generic micro- and nano-electronic technologies (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1157621.25
EU funding (EUR): 1157621.25
Participants: 14
Project status: CLOSED

The semiconductor industry uses a growing variety of materials, as companies seek to further improve devices’ performance to meet increasing market demand in a constant process of innovation. Understanding properties of these innovative materials and nanoforms, and how they behave in living systems, such as the human body, often comes years after the materials have been adopted. Such an inherent uncertainty brings about multiple challenges in the governance of the occupational and environmental risks. This is a common challenge of many technology-intensive sectors, which requires a systematic risk reduction approach. So the application of precautionary approach is warranted for the production process. The high level objectives of the NanoStreeM project are to (i) build inventories of materials, and research directions relevant for nanomaterial use and exposure in nano- electronics manufacturing; (ii) identify gaps in knowledge and methodologies to assess the risk of engineered or accidentally produced nanomaterials (iii) promote open communication with stakeholders to support informed decision making and governance of the risks related to handling of nanomaterials in the semiconductor fabrication process. Planned activities aim to identify best practices used within the industry to control emerging hazards and cross-fertilize with emerging academic approaches in nanosafety. The project will also enable the semiconductor industry to share and benchmark its approach with other sectors for mutual benefit.

Keywords: risk assessment,nanohazard,occupational risks
Nano-particle based enhancement of composite and thermoplastic materials (Nafen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Estonia
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2015, 2015)
Start date: 2015-08-01
End date: 2017-01-31
Duration (months): 18.0
Total project cost (EUR): 3558625.0
EU funding (EUR): 2491037.5
Participants: 1
Project status: CLOSED

ANF Development proposes to develop applications for its nano fiber Nafen, that will include Nafen-modified thermoplastics and Nafen-modified composite materials. The new nano materials will possess superior mechanical properties, which will allow weight reduction and durability increase for polymer finished products and replacement of traditional materials from their applications. ANF will sell to the polymer-processing industry worldwide. ANF will address key challenges in using nano materials for polymer modification: difficulty to access nano fiber, which would give effect at low loadings and at the same time can be industrially available at low cost. Existing nano materials, which are currently used for this purpose, are either unavailable on large scale (single wall CNTs) or require high loads in polymer (multi-wall CNTs, nano silicas, nano clays). ANF will install pilot production facilities for modified thermoplastics and modified composite materials, increase the capacity of Nafen production facility, prepare Nafen masterbatches in thermoplastics and composite materials and test masterbatches in house and at the production sites of industrial co-development partners. After that commercial contracts with interested partners will be signed. With this solution, for the first time, applications will be developed for unique crystalline nano fiber Nafen, which is industrially available at low cost and can be used at low loadings (<1%) in polymers. This makes it possible to (1) achieve polymer goods weight reduction by using less material or making more durable goods (2) achieve fuel economy over the lifecycle of airplanes and vehicles (3) replace traditional materials from their applications. ANF receives several inquiries a week from various polymer industry companies and has agreed with number of them to test Nafen in their material or to co-develop Nafen-modified polymers. Hence, interest in Nafen as nano enhancer for polymers can be demonstrated.

Keywords: nano fiber nafen polymer modification thermoplastics composites mechanical properties
Inline/Instant Measurement for PhArma eXtrusion (IMPAX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2019-10-31
Duration (months): 38.0
Total project cost (EUR): 3276387.5
EU funding (EUR): 2293471.25
Participants: 1
Project status: CLOSED

Most pharma companies still rely on the age old batch manufacturing method and today the European Pharma industry faces the major challenge of strong competition from lower cost manufacturers. The trend is disinvestment in Europe or alternatively investment in innovative manufacturing technologies and more advanced and targeted pharmacological products. Batch manufacturing implies inflexibility, high costs and poor biological delivery of more advanced new drugs. New techniques like Continuous Manufacturing, extruder based Hot Melt Extrusion and Wet Granulation are the future, allowing for automation, improved efficiency, and proper bioavailability for poorly soluble molecules. Safety and fulfilment of their potential mean these new processes require much more advanced Process Analytical Technology than is currently available. ColVisTec will extend its unique UV-VIS platform to incorporate NIR and Raman. IMPAX represents the first production monitoring platform to combine three spectra (UV-VIS, NIR and Raman) and will provide extensive, real time, spectroscopy measurements adapted to the extruder environment with pharma software compliant with EMA and FDA regulations. The initial markets will be Europe and the USA, where ColVisTec is already active. IMPAX users like pharma companies, contract manufacturers and universities will benefit from access to lower cost production and an innovative solution for drug delivery. Important pharma stakeholders (AbbVie, Endcap, FCNW, Catalent, BASF and Reutlingen University) have already shown their interest and support in written form and undertaken to test the new IMPAX platform at their facilities. IMPAX will contribute to Europe’s pharma industry adopting “Industry 4.0” digitalisation and automation principles and will facilitate the European market shift towards CM and PAT techniques boosting the uptake of more competitive manufacturing technologies.

Keywords: pharmaceutical,manufacturing,extrusion,hot melt extrusion,wet granulation,spectrometers
The ultimate digital platform for full transparency and efficiency in the fruits and vegetables trade (B2FRESH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The fruits and vegetables (F&V) trade is organized along the supply chain, where multiple actors from different countries and subjected to different trading requirements exchange information and interact. The ultimate goal of the supply chain is to deliver quality and safe products that meet all the trading requirements and the consumers’ demands. However, the diversity of production areas (international scope), the length of the supply chain, the high number of actors and interlinked relationships between them, the multiple different trading requirements (different in each country and per retailer), the market uncertainty (difficult to foresee harvest and prices) and the perishable nature of the produce affects the smooth functioning of the supply chain and cause inefficiencies. With B2Fresh we aim to provide to the F&V operators (producers, traders and retailers) with a digital platform where they can find all the tools that they need to manage their supply chains in a more efficient and convenient way. We provide an ecosystem of interconnected applications that help visualize, analyse, benchmark and share data locked within the supply chain, removing complexity and reducing duplications. Thanks to our solution, we ease the supply chain management by assuring transparency and the fluent transmission of information. The operators can connect with each other through B2Fresh, so they get a complete overview of the supply chain and can share and access documents (analyses results, certifications, QC reports, specifications), send information request, receive purchase orders, etc. In addition, by aggregating and analysing the platform’s data, we provide our users with performance and benchmarking reports, so they can detect points of improvement otherwise not found. Finally, by making use of concepts such as Big Data and Predictive Algorithms, we are able to offer predictive insights to take the adequate long-term decisions.

Keywords: fruits and vegetables,fresh produce,supply chain management,digital platform,transparency,predictive algorithms,data mining,shelf life,quality control,pesticides