Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms regulating pulmonary neuroendocrine cell (PNEC) growth and tumorigenesis (PNECtumor)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The ultimate goal of my research is to elucidate pathways involved in lung neuroendocrine tumor (LNET) formation. LNETs arise from a rare lung cell population, called pulmonary neuroendocrine cells (PNECs) and account for 20- to 25% of all lung cancers. Despite their involvement in LNETs and a number of other respiratory diseases, relatively little is known about the normal function of PNECs or their contribution to cancer development and progression. Utilizing a novel organoid based strategy for in vitro isolation and analysis of PNECs, I will develop a model of LNE tumorigenesis with a focus on two LNET subtypes, small cell lung cancer (SCLC) and atypical carcinoids (AC). Altogether, the experiments outlined in this proposal are focused on the functional characterization of PNECs and the elucidation of the pathways involved in the transformation of this cell type during LNET formation.

Keywords: lung neuroendocrine tumors,lung cancer,pulmonary neuroendocrine cells,organoids,small cell lung cancer
Blocknetwork - Fusing Big Data and Implementing Novel Cyber Security Solutions (Blocknetwork)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Data science is a driving force in today's information age. As per IDC, global revenues for Big Data and business analytics will grow from $bn 151 in 2017 to more than $bn 210 in 2020, a CAGR of 11.9%. The constant discovery of vulnerabilities in ICT components, applications, services and systems is placing the entire digital society at risk. As private and public stakeholders are becoming increasingly dependent on critical cyber-infrastructure, new solutions are needed to increase detection and response capabilities. Collecting, transferring, processing, analyzing and eventually fusing Big Data remains a complex R&D topic for even the most advanced organization. Those that can surpass the challenges and extract business value will gain significant competitive advantages. Distributed data fusion based on DataUniTor’s Blocknetwork scheme enables a highly secure but still “lightweight” solution capable of handling flowing petabytes (10^15) of data. Blocknetwork is DataUniTor’s unique implementation of blockchain schemes. DataUniTor believes that a self-organized cryptographic Blocknetwork with an evolutionary extension model is the next logical step for blockchain to track complex transactions. The Blocknetwork fuses data sources while also offering additional security features - handling larger volumes, taking fewer instructions and providing a simpler and faster response. The proprietary solution can integrate modules independently of the product provider, allowing for highly flexible structures. Based on technology demonstrations, we assess to be at TRL 6. The overriding objective of the Feasibility Study is to map out the full development and commercialization of the Blocknetwork scheme. We will analyse the technical and economic feasibility of achieving a fast market uptake to exploit a near-term € 133 mill. business opportunity (revenue 2019E-2022E) based on targeting sophisticated medium to large private and public enterprises (B2B).

Keywords: big data fusion,blockchain,cyber security
C-H Activation for Industrial Renewal (CHAIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Germany,Switzerland,Switzerland,Sweden,Poland,Hungary,France,Netherlands,Netherlands,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-07-01
End date: 2024-12-31
Duration (months): 54.0
Total project cost (EUR): 3938269.68
EU funding (EUR): 3938269.68
Participants: 14
Project status: SIGNED

C-H activation is one of the most rapidly expanding areas of molecular chemistry and has emerged as an increasingly viable tool. Despite clear benefits offered by the C-H activation for sustainable and eco-responsible synthesis, its industrial applications are scarce. The lack of its widespread implementation in the industrial sector is due to multiple factors, amongst which the major reasons are a) the limited interactions between academia and industrial practitioners, and b) a limited number of young scientists with a strong expertise in the domain. CHAIR is aimed to specifically address these issues. CHAIR represents a unique European Research Network, combining nine renowned academic research groups and six industrial partners, strongly motivated to settle a solid basement for profound embedment of the C-H activation in an industrial environment. To achieve this ambitious goal 15 ESRs and 15 advanced scientists will be mobilized to implement direct C-H functionalization in industry, including both lead development and process chemistry. Fundamental research projects will be conducted to showcase the potential of the C-H activation to 1) speed up lead-to-hit optimization in pharmaceutical industries; 2) rapidly access molecular diversity; 3) assemble advanced materials; 4) convert raw materials into valuable building blocks; 5) bring new techniques to easily implement C-H activation based protocols for large-scale production. Development of these projects, combined with the scientific training and close collaborations within the CHAIR consortiums through specific secondments will provide 15 ESRs with unique competences in this edge-cutting field. Trainings on personal development, career development and societal/business aspects will complement their unique education, providing them with far-reaching and complementary competences to become future key actors of chemical industries in charge of the modernization of chemical and pharmaceutical industries.

Keywords: c h activation,late stage functionalization,transition metals,biomass valorization,drug,development,functional materials
COst REduction and increase performance of floating WIND technology (COREWIND)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Germany,Germany,Germany,Spain,Belgium,Norway,France,Denmark,Denmark,United Kingdom,United Kingdom
Call: Developing solutions to reduce the cost and increase performance of renewable technologies (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-09-01
End date: 2023-05-31
Duration (months): 45.0
Total project cost (EUR): 5031858.75
EU funding (EUR): 5031858.75
Participants: 19
Project status: SIGNED

Floating offshore wind is still a nascent technology and its LCOE is substantially higher than onshore and bottom-fixed offshore wind, and thus requires to be drastically reduced. The COREWIND project aims to achieve significant cost reductions and enhance performance of floating wind technology through the research and optimization of mooring and anchoring systems and dynamic cables. These enhancements arisen within the project will be validated by means of simulations and experimental testing both in the wave basin tanks and the wind tunnel by taking as reference two concrete-based floater concepts (semi-submersible and spar) supporting large wind turbines (15 MW), installed at water depths greater than 40 m and 90 m for the semi-submersible and spar concept, respectively. Special focus is given to develop and validate innovative solutions to improve installation techniques and operation and maintenance (O&M) activities. They will prove the benefits of concrete structures to substantially reduce the LCOE by at least15% compared to the baseline case of bottom-fixed offshore wind, both in terms of CAPEX and OPEX. Additionally, the project will provide guidelines and best design practices, as well as open data models to accelerate the further development of concrete-based semi-submersible and spar FOWTs, based on findings from innovative cost-effective and reliable solutions for the aforementioned key aspects. It is aimed that the resulting recommendations will facilitate the cost-competitiveness of floating offshore wind energy, reducing risks and uncertainties and contributing to lower LCOE estimates. COREWIND aims to strength the European Leadership on wind power technology (and specially floating). To do so, the project consortium has been designed to ensure proper collaboration between all stakeholders (users, developers, suppliers, academia, etc.) which is essential to accelerate commercialization of the innovations carried out in the project.

Keywords: floating offshore wind energy,mooring and anchoring systems,dynamic cables,oandm,installation techniques,floaters design,lcoe reduction,research,innovation and validation
An innovative fruit ripeness checker, to offer non-destructive testing in order to ensure resource efficient fruit processing - Ripesense (Ripesense)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: United Kingdom
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fresh’ fruits for the consumer market can only be sold as such if they are shown to be a certain standard of ‘ripeness’, as judged by the sugar content and firmness. There is great commercial pressure on producers to provide produce which is of the appropriate standard. Apples which do not meet this standard can be sold to the wholesale market or juiced with losses to market value of 50% and 95% respectively, but apples & citrus fruits which are destructively tested are sold as animal feed, composted or sent to landfill. As a result, fruits are tested many times during the production cycle, both in harvesting and distribution. Unfortunately, the most widely used tests for both are destructive tests. This leads to the destruction of between 6 – 8% of harvested apples and approximately 5% of citrus fruits for testing purposes. Worldwide, this would amount to 4.6 – 6.1 million tonnes of apples and 6.6 million tonnes of citrus fruit annually. At average European prices, this represents a combined economic loss of €6.3 – 7.2 billion every year. Ripesense is an innovative solution to this problem. The objective of our project is to develop and produce an automated system capable of non-destructively testing both the firmness and sugar content of fruits, initially apples and citrus fruits. The main benefits of these performance objectives are to provide a system that can: • Replace destructive test methods with non-destructive ‘Ripesense’, reducing waste fruit going to landfill by 50% • Reduce greenhouse gas emissions produced by waste fruit sent to landfill • Reduce customer complaints 30% by using Ripesense frequently to minimise risk of overripe fruit reaching consumer • Reduce time & labour testing fruits for ripeness, enabling a 50% reduction in QC staff for more advantageous deployment • Allow fruits to be optimally distributed to retailers with different quality criteria, further increasing yield efficiency by ~10% apples

Keywords: fruit sweet landfill non destructive testing apples citrus
PCM-based cold storage as peak shaving for air conditioning units (ColdPeak)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The project deals with the design, customization, fabrication and testing of an innovative Phase Change Material (PCM) – based cold storage system, able to store cold energy as liquid/solid latent heat of a proper material and based on a patent recently developed by Upgrading Services. Thanks to the high charge/discharge cold power of the proposed storage technology due to an innovative heat exchanging strategy, ColdPeak device can be integrated in a Air Conditioning (AC) system as a peak shaving able to: 1- reduce the chiller size and, consequently, its market cost (-20%); 2- allow an almost constant operation of the AC system at its optimal power in terms of COP, improving the system efficiency (+20% at least). Moreover, charging the storage during night hours, when the electricity cost is lower and the outdoor temperature (wet bulb temperature) is colder, the chiller production COP is further improved. The feasibility study performed in Phase 1 will provide a business plan to reach commercialization, including a market study, risk analysis, economic and financial analysis, outlining the business concept and confirming it offers a viable solution to improve AC systems performance. The study will confirm any IPR issues and create a Consortium including agreements with a HVAC manufacturer and a PCM producer.

Keywords: cold storage,energy peak shaving,energy efficiency,air conditioning systems
Probing Physics beyond the Standard Model from Molecules (NEWPHYS-MOLECULES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-11-30
Duration (months): 75.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The Standard Model of physics is incomplete. Gravity is not understood at the quantum level, dark matter and dark energy are not explained, and (string)-theories searching to cover these shortcomings are only consistent in higher-dimensional spaces, while only four of those dimensions are observed. The mystery of finely tuned strengths of the fundamental forces, providing us with a Universe of complexity, remains unexplained. This calls for new physics that can also be explored at the atomic scale in the low energy domain. That is the paradigm underlying the present proposal: Effects of new physics – either related to hitherto unknown particles or to symmetry-breaking phenomena – will manifest themselves as minute shifts in the quantum level structures of atoms and molecules, in minute drifts over time or dependencies on environmental conditions. I propose to perform precision metrology measurements on the H2 molecule in a search for new physics. Deviations between experimental results and QED-theory will scan unexplored territory beyond the Standard Model. Molecular metrology results of the fundamental ground tone vibration in H2 will be confronted with QED-theory calculations to search for the existence of new forces at the Angström length scale. If extra dimensions beyond the known 3+1 would be compactified at the same length scale of 1 Å, this would lead to strongly enhanced gravitational effects, measurable in a molecule. Our current research on experimental probes for varying constants on a cosmological time scale, is redirected into the investigation of chameleon scenarios: by studying H2 molecules in white dwarf stars by uv-astronomy, and by studying methanol molecules in our own galaxy by radio astronomy, searching for a possible dependence of fundamental constants on strong gravity or on density. If any of these targeted phenomena could be uncovered, it would have great impact on science as a whole, and on our view on the Universe and its origin.

Keywords: laser physics,quantum electrodynamics,precision spectroscopy,molecular astrophysics,fith forces,dimensionality of space time
Animals in the Philosophy of the Islamic World (IslamAnimals)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 2343661.0
EU funding (EUR): 2343661.0
Participants: 1
Project status: SIGNED

Are animals conscious? Can they think or feel emotions? What makes them different from humans on the one hand and plants on the other? And how should we treat them? This project will bring to light a rich body of texts written in the Islamic world, which address just such questions about the value and nature of animals. Contrary to common assumptions, such questions were taken seriously in pre-modern thought. Scholars have explored ancient Greek and Indian discussions of animals, but little attention has been paid to the contribution of Islamic culture, which produced e.g. philosophical and scientific works on animals, moralizing fables featuring animal characters, and treatises on veterinary medicine and on the types and uses of animals. We will uncover the changing conceptions of animals revealed in such works, taking an innovative approach which explores the interaction between descriptive and normative accounts of animals. We seek to understand, for instance, how developments in ideas about animal souls impacted ideas about the ethical treatment of animals. We will also investigate the historical genesis of this corpus of texts on animals, by exploring the influence of three literary traditions: Aristotelian zoology, medicine, and the founding religious texts of Islam. An ideal host environment, along with the PI’s expertise in Greek-Arabic cultural transmission and prior work on the interaction between philosophy, medicine, and theology, provide an ideal opportunity to explore the shift in attitudes towards animals that grew out of these three traditions. The impact of the project will be three-fold. It will (1) open up the philosophy of animals as a hitherto neglected field within Islamic studies; (2) provide a generalizable model of research on the interplay between normative and descriptive drivers of conceptual change; and (3) demonstrate that classical Islamic culture can speak to a moral issue that is hotly debated in contemporary European society.

Keywords: animals,zoology,islam,arabic,medicine
Developing perovskite-based solar panels (AlbaSolar)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Hungary
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Silicon based solar panels dominate the photovoltaic (PV) market but it seems they have reached their limits due to three major limiting factors: (1) high manufacturing costs, (2) inflexible shape and (3) not improving efficiency. These factors do not allow PV prices to drop under a theoretical minimum resulting in the fact solar investments have a reasonable ROI only with state subsidies, which is a major obstacle in the way of the further spreading of renewables, although they could be the answer for the world’s energy security and fossil energy reduction issues. The project aims to break these barriers by exchanging the silicon based active layer with perovskite based composites, this innovation offers a solution for all of the 3 aforementioned hindrances. In our revenue model two types of solar panels will be sold through direct (own sales network, webshop) and indirect (distributors) channels. Expected direct/indirect sales ratio will be 50-50% by the end of the initial business period. The overall market (TAM) is global (size ~2.8 bn EUR), the initial market segment is Europe (size: ~ 1/3 of TAM).. Targeted users are companies the with the profile of fulfilling the end users’ (households, public institutions, industry) energy needs by building or installing solar farms or solar based systems. Competitive advantages: (1) significantly cheaper (1/3) price; (2) only slightly less (but rapidly increasing) performance; (3) flexible shape; In Phase 1 focus will be on a technical viability check covering potential material compounds, issues of scaling up the cell, efficiency and lifespan analyses; market survey to support our market concept; conducting an FTO analysis. Project plan of Phase 2 and a detailed business plan will also be elaborated. The TRL-9 level product is being planned to be elaborated in the frame of Phase 2, estimated cost is 1,500,000 EUR.

Keywords: perovskite based composite,solar panels,photovoltaic