Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Force, Motion and Positioning of Microtubule Asters (FORCASTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 2199310.0
EU funding (EUR): 2199310.0
Participants: 1
Project status: CLOSED

Cells must move and position internal components to perform their function. We here focus on the physical designs which allow microtubule (MT) asters to exert forces in order to move and position themselves in vivo. These are arrays of MTs radiating from the centrosome, which fill up large portions of cells. They orchestrate nuclear positioning and spindle orientation for polarity, division and development. Forces that move asters are generated at nanometer and second scales by MT-associated motors from sites in the cytoplasm or at the cell surface. How MTs and force-generators self-organize to control aster motion and position at millimeter and hour scales is not known. We will use a suit of biophysical experiments and models to address how aster micro-mechanics contribute to aster migration, centration, de-centration and orientation in a single in vivo system, using the early stages of Sea urchin development as a quantitative model. We aim to: 1) Elucidate mechanisms that drive aster large-scale motion, using sperm aster migration after fertilization during which asters grow and move rapidly and persistently to the large-egg center. We will investigate how speeds and trajectories depend on boundary conditions and on the dynamic spatial organization of force-generators. 2) Implement magnetic-based subcellular force measurements of MT asters. We will use this to understand how single force-events are integrated at the scale of asters, how global forces may evolve will aster size, shape, in centration and de-centration processes, using various stages of development, and cell manipulation; and to compute aster friction. 3) Couple computational models and 3D imaging to understand and predict stereotyped division patterns driven by subsequent aster positioning and aster-pairs orientation in the early divisions of Sea urchin embryos and in other tissues. This framework bridging multiple scales will bring unprecedented insights on the physics of living active matter.

Keywords: cytoskeleton,microtubules,cell shape,cell mechanics,microfabrication,modelling
Applying circular economy solutions in industrial wastewater management: request of SME Associate to develop the necessary energy simulation tools for recovery of waste heat from industrial operations (BRINE MINING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 82000.0
EU funding (EUR): 82000.0
Participants: 1
Project status: CLOSED

Global competition for water is increasing and is expected to lead to social, economic, environmental and geo-political consequences. Desalination provides a promising solution for the water crisis. However, current desalination technologies cause serious environmental impacts, due to the wastewater effluent called "brine". At the same time, this brine contains valuable materials which can, if recovered, create significant value and job opportunities for our economies. BRINE-MINING project aims to develop the 1st Circular Economy Plan for closing the loop of desalination wastewater, by applying an eco-innovative technology developed in previous EU projects in industrial environment, while exploiting waste heat available.The company is commercializing an eco-innovative technology that was demonstrated successfully at pilot scale, within the European project SOL-BRINE (BEST LIFE 2015 ENVIRONMENT project). The research was further advanced through a second EU funding, to elaborate a feasibility study (SME Project No. 674455). To do so, our company needs expertise in advanced simulation tools that will allow integration of our technology in the industrial environment, by making optimal use of the waste heat available. This is expected to reduce drastically the operating expenditure of the solution provided, achieving competitive prices and thus empowering our unique selling proposition. The ultimate goal will be to recruit a talented researcher in the position of Senior Software Development Engineer, who will be able to apply his expertise in order to realize our innovation potential. This is expected to contribute significantly to the growth of our company, creating approximately 6 new job positions and the possibility to collaborate with the SME Associate on a permanent basis towards our game changing path of making desalination circular.

Keywords: brine,management,waste heat,simulation,energy recovery,circular economy,resource efficiency
Roto-Hybrid Process® Cylinders for Green Gravure Printing (Green Gravure)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-05-31
Duration (months): 30.0
Total project cost (EUR): 3071603.75
EU funding (EUR): 2150122.64
Participants: 5
Project status: CLOSED

The Green Gravure project aims to bring to the market the state-of-the-art Roto-Hybrid Process which combines two novel pre-press gravure printing cylinder process technologies; Hybrid Cylinder technology to enable size variable printing cylinder production and a Diamond-Like Carbon coating process to replace chrome plating and other electrolytic processes like copper or nickel plating. The Roto-Hybrid Process provides a unique solution to help address key challenges facing the global gravure printing industry, enabling faster, more cost effective and environmentally friendly cylinder production and processing to help strengthen the competitiveness and sustainability of Europe's gravure printing industry. Through the collaboration of the Green Gravure project partners, this FTI Pilot project will advance the Roto-Hybrid Process to market, developing a final prototype system in an operational environment (TRL 8) and through trials with end users, the partners will demonstrate the key benefits of the solution and the business opportunity which is supported by comprehensive market and competitor analysis and a robust business plan. In cooperation with a number of cylinder engravers and gravure printing firms already engaged with the project partners, the added value this project will demonstrate within the global gravure market will attract further interest from target users, which will enable the technology owners within the consortium to establish joint ventures and licensing deals for wider market uptake and to boost global market penetration and turnover for the benefit of all industry partners involved in this project.

Keywords: gravure printing cylinders
Refugees are Migrants: Refugee Mobility, Recognition and Rights (REF-MIG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1499611.0
EU funding (EUR): 749283.89
Participants: 2
Project status: SIGNED

This project begins with the basic premise that refugees are migrants: by legal definition and political conception, they have left their home countries to seek refuge. This project aims to re-assess refugee protection through a lens of mobility and migration, locating the study of refugee law in the context of the refugee regime. It examines the three key aspects of refugee law – access to protection, refugee status determination, and refugee rights – bringing them into conversation with the refugee regime’s norms and practices on responsibility-sharing and solutions. Crucially, the project takes a long and broad view of refugee protection, in order to open up new possibilities and trajectories. It also integrates a legal assessment of the role of non-state actors in refugee protection. Using the broad notion of ‘intermediary’ in the migration process, it will assess the regulatory environment on access to protection, so-called ‘secondary movement’ and onward migration. It will provide an important legal assessment of the role of the International Organisation for Migration (IOM) and the duties of humanitarian actors in refugee protection. It addresses the EU, not as a singularity, but as an actor in the global regime. The project is methodologically ground-breaking. It identifies practices that determine access to and the quality of refugee protection, and how these practices have developed across jurisdictions and over time, thereby historicizing and reframing the practices in question. As well as rigorous doctrinal (‘black letter’) legal analysis, it will use go beyond doctrine, and draw on theoretical conceptions of legality to explore the particular modes of regulating mobility and migration that are now central to refugee protection. It will also develop new inter-disciplinary methods, using comparative legal, historical and political-scientific tools.

Keywords: international refugee law,global refugee regime,migration,refugees as migrants
Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis (Host-TB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-06-01
End date: 2025-08-31
Duration (months): 75.0
Total project cost (EUR): 2160926.0
EU funding (EUR): 1366940.49
Participants: 2
Project status: SIGNED

With more than 10 million cases annually, tuberculosis (TB) remains a global health problem. TB epidemic is exacerbated by the spread of multidrug-resistant TB. Host-directed therapies (HDTs) can improve immune mechanisms by augmenting the ability of host cells to kill M. tuberculosis (Mtb) or by modulating the immune response to prevent excessive inflammation, cell death and tissue damage. Progress with HDT development has been slowed down by the limited understanding of host-pathogen interactions during Mtb infection. Screens of the whole human genome can identify novel genes involved in the immune responses to Mtb infection and susceptibility to TB. Previously, we successfully used genome-wide association studies to identify human genes associated with susceptibility to TB. Here, we will for the first time use the groundbreaking CRISPR technology to screen the human genome in macrophages infected with Mtb and discover genes that are critically involved in host-pathogen interactions. Then, we will comprehensively characterise pathways that mediate impacts of these genes on both the human macrophage and the intracellular Mtb bacilli using dual transcriptome analyses and high-throughput microscopy assays. This novel approach will dissect crucial mechanisms of host-pathogen interaction during Mtb infection and will point to new targets for HDTs of TB.

Keywords: tuberculosis
first and euRopEAn siC eigTh Inches pilOt liNe (REACTION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Spain,Italy,Italy,Italy,Italy,Italy,Italy,Austria,Germany,Germany,Germany,Germany,Ireland,Italy,Italy,Italy,Israel,Spain,Italy,Belgium,Romania,Slovakia,Sweden,Switzerland,Sweden,Poland,Poland,France,United States
Call: IA (H2020-ECSEL-2017-1-IA-two-stage, 2017)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 49767672.5
EU funding (EUR): 10401952.25
Participants: 37
Project status: SIGNED

REACTION will push through the first worldwide 200mm Silicon Carbide (SiC) Pilot Line Facility for Power technology. This will enable the European industry to set the world reference of innovative and competitive solutions for critical societal challenges, like Energy saving and CO2 Reduction as well as Sustainable Environment through electric mobility and industrial power efficiency. Establishing the first 200mm SiC Pilot Line in the world and developing the most innovative and cost competitive technology, this project will address mass-market applications like smart energy and smart mobility, and industrial. It will allow to meet the more and more increasing demand of requirements in terms of quality and cost constraint for next decade generation’s power electronics. The Project strength is the complete Pilot Line value chain implementation, integrating and optimizing partnership in the fields of SiC equipment developers, SiC process technologists, RTOs, and end users partners till the final applications context. This will allow to develop a full 8” SiC line ecosystem enhancing the competitiveness of EU- Industries down to the value chain in a market context where other countries today, such as the USA or Japan, are just starting to play on 6” SiC market. Innovative SiC power device Performances improvements, together with cost and size reductions, are the most relevant challenges addressed in the project that are expected to lead to a new stronger European supply chain for very compact SiC converters, from 600V to 2.2kV range, ideal for the addressed applications; the ambition is therefore to play a primary role towards excellence in Europe by a first generations of 8” SiC profitable Smart Mobility and Smart Energy products and components, primary access to IPs for the relevant essential capabilities, competitiveness of manufacturing in Europe.

Keywords: silicon carbide,8 inches wafer,pilot line
Carpel evolution: a walk in the rice side (RiceStyle)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,China
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 223120.8
EU funding (EUR): 223120.8
Participants: 2
Project status: CLOSED

Flowering plants (angiosperms) protect their female reproductive structure, the ovule, within a carpel. After the embryo sac in fertilized by the pollen tube, the ovule gradually turns into a seed, and the carpel becomes a fruit. The carpel is thus an evolutionary conserved structure, but showing an outstanding variability in shapes and function. Several transcription factors directing the main aspects of carpel formation and morphogenesis, are quite well characterized in the model eudicot plant Arabidopsis thaliana. More recent evo-devo studies suggest that some of these transcription factors are functionally, conserved, at least in eudicot plants. However, this knowledge is far to be complete, especially if we consider the basal angiosperm taxa and monocots. This proposal aims to investigate more in depth these phenomena, using as main model species rice (Oryza sativa), and subsequently to do comparative studies in other evolutionary significant species. The final goal is to achieve a broader knowledge about the transcriptional machinery ruling carpel development, and its degree of functional conservation among the most relevant angiosperm taxa, by means of innovative techniques. The proposal will also allow us to address new evidence about the molecular pathways acting downstream this transcriptional network. The proposal will have a significant impact in basic and future applied research, addressing the Horizon 2020 objective to invest in future jobs and strengthen EU position in research, innovation and technology, sustainable development climate change excellent science.

Keywords: oryza sativa,angiosperms,evo devo,carpel,style,stigma,transcription factors
Support to aerodynamic analysis and design of propellers of a compound helicopter (PROPTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Netherlands,Netherlands
Call: Support to the aerodynamic analysis and design of propellers of a compound helicopter (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2015-12-01
End date: 2019-03-31
Duration (months): 40.0
Total project cost (EUR): 409252.5
EU funding (EUR): 409252.5
Participants: 2
Project status: CLOSED

PROPTER addresses the analysis and design of propellers operating in the complex flow field around a compound helicopter where a strong interaction with airframe and lifting rotor occurs. The objectives are well-thought out to ensure (i) sound understanding of the physics of the interactional flow, (ii) appropriate advancement and deployment of high-fidelity CFD methods for obtaining high confidence results, and (iii) smooth integration of the generated knowledge into the industrial environment. These objectives are referenced throughout the proposal giving a coherent chain from concept to implementation formulated to achieve the main project goal: propeller design optimized for implementation in a compound helicopter. PROPTER encompasses an analysis and design process with a wide range of physical complexity and method fidelity, from a rather simple configuration (isolated propeller) but challenging task (propeller design for multiple flight cases), to a complex configuration (propeller-rotor-airframe) involving a complex unsteady interactional flow. It deploys the best of two worlds of CFD software: (i) ENFLOW, a research code developed at NLR in various European and national research programmes, and (ii) ANSYS-FLUENT, a commercial code used at the topic leader. A code-to-code comparison, both for analysis results and design results, will give a sound understanding of the modelling and best practices applied. This forms the basis to achieve high confidence for the numerical results and their integration in the industrial environment. PROPTER consortium, National Aerospace Laboratory (NLR) and Delft University of Technology (TUD), provides complementary expertise, skill and infrastructure vital to the project’s success. To be executed in good coordination with the topic leader, PROPTER is essential to the success of the LifeRCraft project in opening up new mobility roles that neither conventional helicopters nor fixed wing aircraft can currently cover.

Keywords: compound helicopter,propeller interaction,aerodynamic design
Safe and secure mixed-criticality systems with low power requirements (SAFEPOWER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Sweden,Sweden,United Kingdom
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 4003625.0
EU funding (EUR): 3621050.0
Participants: 8
Project status: CLOSED

Critical Real-Time Embedded Systems (CRTES) such as railway, aerospace, automotive and energy generation systems face a disruptive challenge caused by the massive irruption of mixed-criticality systems based on multicore processors. At the same time low-power is an intensifying demand in many market segments, a competitive advantage for CRTES that have to operate with limited energy (e.g., battery powered systems), an enabler for higher availability and a desired feature towards near-zero emission in systems with tens/hundreds of devices. Power is also a key aspect in mixed-criticality systems as another resource (together with time and space) that has to be shared among different applications and has to be strictly controlled not to cause undesired interferences. The main objective of SAFEPOWER is to enable the development of mixed-criticality systems with low power, energy and temperature in combination with safety, real-time and security support by a reference architecture orchestrating different local power-management techniques. SAFEPOWER builds a comprehensive suite of multi-core platform technologies as well as analysis, simulation and verification tools for low-power mixed-criticality systems, including hardware and software reference platforms assisting the implementation, observation and test of such applications. SAFEPOWER will demonstrate the benefits through two industrial use-cases and a cross-domain public demonstrator. The safety concept of SAFEPOWER will be assessed by an external certification authority and consider reference domains and safety standards (e.g. industrial IEC-61508, railway, automotive, aerospace). SAFEPOWE brings significant improvements w.r.t. power, energy, temperature, availability and lifetime of CRTES as well as new types of competitive products operating with limited energy. Impact and exploitation will also be facilitated by the strong collaboration with other related projects in the cluster of mixed-criticality systems.

Keywords: safety critical systems,mixed criticality,low power,power management techniques,power aware,reference architecture,cross domain,certification,use cases,demonstrator