Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human cardiac microtissues for studying lamin cardiomyopathy (ACCURACY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Lamin A/C cardiomyopathy (LMNA-CM) is a rare genetic disorder caused by mutations in the nuclear lamin gene LMNA. Affected patients typically exhibit dilated cardiomyopathy and reduced life expectancy, due to sudden cardiac death or accelerated functional decay requiring the heart transplant. Intriguingly, carriers of the same LMNA mutation show a wide spectrum of genotype-phenotype discrepancy, however a clear mechanistical understanding remains elusive. Recently, the host laboratory has developed an innovative multicellular three-dimensional (3D) human induced pluripotent stem cells (hiPSC)-cardiac microtissue (MT) model where hiPSC-derived cardiomyocytes display post-natal maturation allowing more faithful investigation of normal and pathological cardiac physiology. I will leverage this model and combine it with my strong background in molecular and cellular cardiology to advance the understanding of LMNA-related pathologies. Specifically, I will use patient-derived hiPSC from two family members with a severe and less severe form of LMNA-CM and their isogenic controls to generate 3D MT models. Next, I plan to 1) characterize structural and functional properties and the transcriptome profile of multicellular LMNA MT models and their controls, 2) investigate cell-cell (cardiomyocytes, endothelial cells, cardiac fibroblasts and macrophages) interactions relevant to the disease development and progression, and 3) correct the identified molecular targets by pharmacological treatment or by CRISPR-mediated gene editing. The scientific, industrial and economic community will profit from this project twofold. First, I will establish a cost-effective model that provides better understanding of LMNA-CM pathogenesis, avoids cross-species variability and reduces the need for animal research and second, I will test the implementation of potential treatment options with the ambition to achieve a step forward in developing personalized therapeutic approach for the end users.

Keywords: human induced pluripotent stem cells hipsc,cardiac microtissue,cardiac organoid,lmna,lamin a c cardiomyopathy,familial dilated cardiomyopathy,crispr cas9 gene editing
Gaze ID: Oculomotoric Biometric Authentification (Gaze ID)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1714677.0
EU funding (EUR): 1714677.0
Participants: 1
Project status: SIGNED

Secure user authentication is needed to authorize payments, and to control access to information spaces and physical sites. Known biometric modalities are vulnerable to presentation ("spoofing") attacks; for instance, by 3D-printed finger replicas, 3D-printed or theatrical masks, or contact lenses with a person's iris printed onto them. At Amphiprion, we address the market need for biometric authentication that is resilient against even high-effort presentation attacks. We develop Gaze ID: biometric authentication technology that leverages unique dynamics characteristics of saccadic eye movements and subconscious, high‐frequency micro‐movements. Gaze ID offers unique resilience against attacks, because it involves a subconscious challenge‐response mechanism: A potential attacker would have to simulate how a target person’s brain subconsciously controls the eye movements in response to a visual stimulus. Dead‐man attacks with incapacitated users are not possible, because functioning vision is required for authentication. Gaze ID is also the only biometric modality that even allows users to signal coercion attacks by executing pre‐defined patterns of deliberate, macroscopic eye movements. Gaze ID can distinguish identical twins, and it can be combined with face recognition using the same sensor. Our current product tablet-based prototype reaches TRL4. Our customers are OEMs of access control systems and of smartphones. Our business proposition for smartphones is that Gaze ID and face recognition can be combined using the selfie camera, which achieves the highest level of security and resilience and allows OEMs to remove the expensive, dedicated sensor for 3D face recognition. With 1.2 bn smartphones sold per year this creates an annual SOM of 380 m Euros. We have established relationships and sales leads to 6 of the 10 largest smartphone OEMs.

Keywords: biometrics,machine learning,access control
Eigenvalue optimisation and Minimal surfaces (EOaMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1442198.0
EU funding (EUR): 1442198.0
Participants: 1
Project status: SIGNED

This project is positioned on the interface between spectral theory and geometric analysis, and is concerned with the relation between certain analytic invariants of objects (called spectra) and the shape (or geometry) of these objects. A classical example of a spectrum is a Laplacian spectrum. It is a sequence of numbers encoding the information about many physical properties of an object such as elasticity, heat and sound propagations and many others. Specifically, this project deals with the geometry of special shapes such as soap films. The geometry of soap films (the so-called minimal surfaces) is a central subject of modern geometric analysis with applications far beyond the one suggested by their name, most prominently to topology and theory of general relativity. More precisely, the project is devoted to the study of two classical topics: sharp inequalities for eigenvalues of geometric operators on manifolds and minimal surfaces. The underlying principle of the field is the correspondence between minimal surfaces and optimal metrics for such inequalities. This correspondence is both a source of many fascinating intradisciplinary connections (e.g. with analysis, geometry, algebra and theory of integrable systems) and a powerful methodological tool. A variety of methods from across mathematics can be applied to this problem and recent advances have resulted in a resolution of several classical problems on either side of the correspondence. The present project aims to build on this success story by targeting long-standing conjectures in the following directions: 1) Using the correspondence to construct many novel examples of minimal surfaces, study their geometry, and look for new patterns and phenomena; 2) Applying methods of geometric analysis to find sharp eigenvalue inequalities for classical eigenvalues problems; 3) Extending the realm of potential applications by exploring different eigenvalue problems for similar connections to geometric analysis.

Keywords: laplacian,eigenvalue optimisation,dirichlet to neumann map,minimal surfaces,harmonic maps
Precision Nutrition to optimize immune response for metabolic health (NUTRIMMUNE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France,Germany,Switzerland,Netherlands
Call: EIC Pathfinder Challenge: Precision Nutrition (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 4318432.5
EU funding (EUR): 4318432.5
Participants: 7
Project status: SIGNED

NUTRIMMUNE examines how dietary factors affect immune responses across varying degrees of obesity-related Noncommunicable Disease (NCD) severity. This focus is crucial given obesity’s link to NCDs and infection risks. The project gathers 6 academic groups and 1 SME across 4 European countries over 4 years and a €4.3M grant to evaluate the interplay between nutrition, glycome, microbiome, and immune health in obesity and immune impairment. NUTRIMMUNE leverages partners: i) Access to European databases and biobanks, enabling in-depth analysis at cellular and molecular levels, ii) Proficiency in conducting dietary intervention studies in human subjects, and iii) Experience in mechanistic and functional diet-glycome-microbiome interactions. In WP1, the project deciphers phenotypic, multi-omics, and dietary factors responsible for variability in Immune Checkpoint (ICP) expression and immune impairment in existing cohorts. WP2 focuses on a 24-week precision nutritional intervention to assess the potential of a pro-immune diet to restore T cell fitness in obese subjects. WP3 conducts comprehensive profiling before and after the dietary intervention, examining innate and adaptive responses, cytokine patterns, alongside ICP labeling. WP4 provides mechanistic aspects on how the diet, glycome, microbiome influence immune health. WP5 employs machine learning models to identify predictive markers and signatures for ICP expression and altered immunity, to identify dietary patterns and food affecting immune function. WP6 ensures efficient project management and effective coordination, ethics compliance, dissemination, and exploitation. WP7 explores synergies with portfolio projects for challenge goals. The project’s goal is to move from our novel idea that precision nutrition influences immunity via microbiome and glycome, and present validated proof-of-concept evidence for nutritional recommendations and future food development.

Keywords: immune health,metabolism,nutrition,microbiome,glycome,precision nutrition
Detecting the world's most accurate field boundaries (CropCloud)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 2531250.0
EU funding (EUR): 1767500.0
Participants: 1
Project status: CLOSED

DigiFarm detects the world’s most accurate field boundaries and seeded acres to power precision agriculture. Leveraging the latest advancements in Artificial Intelligence technology and super-resolution of Satellite data, our object detection algorithm achieves higher accuracy than the human eye, resulting in 12-15% higher accuracy than existing solutions.
Explaining and Predicting the Ocean Conveyor (EPOC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: United States,United Kingdom,France,Germany,Norway,Spain,Faroe Islands,Canada
Call: Key oceanic and polar processes driving regional & global climate change (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 5294019.25
EU funding (EUR): 5294019.25
Participants: 25
Project status: SIGNED

EPOC will generate a new conceptual framework for the Atlantic meridional overturning circulation, to understand how it functions in the Earth system and impacts weather and climate. The AMOC is a key component of the climate system, responsible for ocean heat and freshwater transport, associated with the ventilation of anthropogenic carbon, and anticipated to experience or drive climate tipping points. However, the link between ocean transport, ventilation and tipping points relies on the common conceptual view of the AMOC as a ‘great ocean conveyor’ which was developed to explain very long timescale (glacial-interglacial) fluctuations in climate. The conveyor-belt schematic conflates millennial timescales with human timescales (days to 100 years), leading to misconceptions by the observing and modelling communities, and misplaced expectations about the AMOC’s role in climate. EPOC will capitalise on new understanding about the AMOC variability and coherence from two decades of AMOC observations and advances in ocean observing technology and climate modelling, to develop new tools and approaches to quantify and explain past AMOC change and how its connectivity or lack thereof imprint on the Earth system. Through joined-up observational and model experiments, focussing on next generation high resolution coupled models, machine learning techniques and critical re-assessment of paleo proxies, EPOC will generate a new conceptual framework for the AMOC, its meridional connectivity, feedbacks and the relationship between ventilation and overturning on human timescales. This will lead to better predictions of the AMOC and related climate evolution, including the risk of rapid change.

Keywords: amoc,conveyor belt,high resolution models,proxy records,ocean physics,coupled model intercomparison
Preparatory Phase for the Einstein Telescope Gravitational Wave Observatory (ET-PP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Hungary,Austria,Switzerland,United Kingdom,Italy,Poland,France,Netherlands,Belgium,Germany
Call: Preparatory phase of new ESFRI research infrastructure projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 11915820.0
EU funding (EUR): 3450000.0
Participants: 16
Project status: SIGNED

Einstein Telescope (ET) will be the European Third-Generation (3G) Gravitational Wave (GW) Observatory, designed to observe the Universe by covering the whole spectrum observable from Earth with interferometric GW detectors. ET will put Europe at the forefront of the GW research being the first and most advanced 3G GW observatory. Europe will take the lead in the newborn multi-messenger astronomy by combining information delivered by ET with optical, IR, UV, gamma, cosmic ray and neutrino telescopes observations. ET will impact on our fundamental physics knowledge, and our understanding of the fundamental interactions governing the evolution of black-holes and neutron stars. The ET preparatory phase (ET-PP) will address a number of fundamental prerequisites for the approval, construction and operation of ET: the enlargement of the ET consortium, the legal framework, governance schemes, and financial regulations under which ET will be constructed and operated; the detailed technical design and costing of the ET observatory; the preparation of the ET site selection; detailing and cost-estimation of the required site infrastructure, and its socioeconomic and environmental impacts; the schemes for technology transfer, procurement and industry involvement in the technical design and construction of ET; the required linking with relevant science communities regarding the detailed definition of the science program, and the user services and data access model. For ET-PP, support is sought for work on the legal, governance and financial issues, for the installation of a project office coordinating and supporting management of ET-PP as well as the design of ET and the planning of the implementation, for site-related work, for studies regarding the optimization and production of ET components by industry, for linking with science communities and for increasing social awareness. Hence, ET-PP will deliver a detailed implementation plan for the ET infrastructure.

Keywords: einstein telescope consortium,governance,finances,project office,site selection,technical design,industry,sustainability,science program,multi messenger,data access,social awareness,impact
Understanding groundwater Pollution to protect and enhance WATERquality (UPWATER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Denmark,France,Greece,Netherlands,Portugal,Australia,Germany
Call: Preventing groundwater contamination and protecting its quality against harmful impacts of global and climate change (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 3993637.25
EU funding (EUR): 3993637.25
Participants: 14
Project status: SIGNED

Among the available freshwater resources, groundwater (GW) plays a key role in providing water supplies and livelihoods to respond the pronounced water scarcity. GW pollution by chemicals (organic and inorganic) and biological agents (viruses and bacteria) originating from human activities is a widespread worldwide problem. The scientific and technological goals of the UPWATER project are (1) to provide scientific knowledge on identification, occurrence and fate of pollutants in the GW with cost-efficient sampling methods based on passive samplers for chemicals and pathogens; (2) to develop sources apportionment methods to identify and quantify the pollution sources, including Compound Specific Isotopic Analysis (CSIA) and (3) to validate and assess the performance of bio-based engineered natural treatment systems designed as mitigation solutions. The monitoring and mitigation solutions will be validated in 3 case studies (DK, GR and ES), representing different EU climate conditions and a combination of rural, industrial and urban pollution sources. The existing hydrogeological models will be updated with innovative water quality modelling tools, allowing the simulation of decision-making scenarios under multiple stressors and climate change projections. The scenarios will also include the expected impacts of scaling-up the mitigation solutions and the adoption of other non-technological preventive measures devoted to minimise the release of chemicals at source (chemicals regulation, taxation, consumption campaigns, public procurement, etc). The exploitation of specific UPWATER results will lead to expected mid-term outcomes including among others: updating the EU chemical priority lists, scaling-up the pilot bio-based solutions to demonstration scale, the adoption of some preventive measures in the case studies and the close-to-market development of the passive sampling devices.
NEXt generation of sUstainable perovskite-Silicon tandem cells (NEXUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Netherlands,Spain,Switzerland,France,United Kingdom,Belgium,Türkiye
Call: Novel tandem, high efficiency Photovoltaic technologies targeting low cost production with earth abundant materials (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 3865826.7
EU funding (EUR): 3865826.7
Participants: 15
Project status: SIGNED

NEXUS will accelerate Europe’s transition to clean energy by development of perovskite-Si tandem photovoltaics, via a new European paradigm: a global eco-design approach based on efficiency, cost, sustainability, circularity and social aspects, using abundant materials in the whole value chain. Our innovations will improve the PV Energy Yield per area, using sustainable, coherent and competitive European PV production, guaranteeing a clean energy transition and ensuring a secure and affordable EU energy supply. NEXUS will develop stable, 2-terminal perovskite-Si tandem solar cells with power conversion efficiencies >33% (modules >30%) and stabilities like state of the art single junction Silicon PV modules. We will develop these challenging targets following an innovative eco-design approach: employing solvent-free perovskite deposition, circularity, recyclability, improved simple manufacturing processes, to create a viable economic pathway for the European commercialization of this sustainable technology. Advances are based on development of high-performance, solvent-free, perovskite top absorbers, of conductive oxides based on earth abundant materials for different applications and the implementation of eco-design criteria for development of the bottom PV-Si cell, reducing its CO2 footprint. Thus we will achieve perovskite-Si cells and modules with a maximized power output of 210 kWh/m2. We will increase durability and sustainability in a novel silicon technology, while developing new approaches to deliver very high voltage perovskite solar cells with unprecedented resilience to environmental stress factors. We will demonstrate scalability and proof-of-concept equipment set for each step. NEXUS is a multi-disciplinary consortium: 12 partners from 9 European countries; 5 industrial partners (2 SMEs) & 7 Research & Technology organizations, covering the whole value chain of innovation from research centers to technology providers, end-users and market and policies.

Keywords: photovoltaics,perovskite,tandem,silicon,solar,sustainability,terawatt