Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CONSORTIUM FOR DEVELOPING REGULATORY CAPACITY FOR CLINICAL TRIALS USING GENE THERAPY PRODUCTS AND STRENGTHENING PHARMACOVIGILANCE IN THE CONDUCT OF CLINICAL TRIALS IN EAST AFRICA (CAPACITY 2023)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Uganda,Tanzania, United Republic of,Portugal
Call: Strengthening ethics and regulatory capacity (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 999315.35
EU funding (EUR): 999315.35
Participants: 5
Project status: SIGNED

Gene therapy advancements have shown promise in treating chronic conditions like HIV and Sickle cell Anaemia and have the potential to greatly reduce the burden of disease in Sub-Saharan Africa which is plagued with a double burden of communicable and non-communicable diseases. These treatments have the potential to reduce the burden of disease for the populations for which they are targeted and the cost of treatments for governments. In Sub-Saharan Africa, there are largely no or unclear regulatory frameworks for clinical trials using Gene Therapy products. As pioneers setting up frameworks for regulatory oversight of clinical trials using Gene and cell-based therapy products, Uganda and Tanzania will be able to share this knowledge through regional platforms to support other countries in the region to put in place similar regulatory frameworks. Additionally researcher workshops and course developed on Gene Therapy Products will build capacity among researcher, regulators and the public. Pharmacovigilance in clinical trials for safety of trial participants and to accurately characterize the safety profile of the drug for the targeted patient population. Safety monitoring in clinical trials in the region, currently faces challenges associated with health system challenges, investigator awareness, poverty and limited access to diagnostic tools. Additionally, there is limited investigator awareness of of their responsibility to the patients with regard to monitoring and treating and accurate reporting of serious adverse events during clinical trials. The results of this project will also provide a basis to sensitize investigators/sponsors and engage policymakers on the requisite health systems reforms to create a safe environment for the conduct of clinical trials with the ultimate goal of accelerating research, registration and access to these new medicine technologies.

Keywords: gene therapy,regulatory framework,capacity building,pharmacovigilance,clinical trials
Forecast of Actionable Radiation Belt Scenarios (FARBES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Hungary,France,United States,Czechia,Greece,United Kingdom
Call: Space Weather (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 816236.25
EU funding (EUR): 816236.0
Participants: 6
Project status: SIGNED

Forecast in Space Weather modeling mostly ignore the fact everything is driven by the sun, that is basically unpredictable. Propagating observed solar dynamics to Earth is questionable, it depends on models whose boundary conditions we are incapable of constraining. We are limited to data at L1, giving a one hour lead time and neural net type forecasts of controlling parameters ( e.g. Kp) that govern the physics of our best models. Nowcasts are better: advanced data assimilation techniques with physics based models show great fidelity in reproducing the real radiation belt (RB) environment. Operational use of such Nowcasts is limited by lack of high quality real-time data beyond GEOS. The FARBES project is different: it limits its ambition to simple, achievable prediction goals that are of utility to satellite operators, while avoiding the pitfalls of past projects. We hold that while it may be impossible to accurately predict the break of a space weather event, once an event has started we have the tools to predict subsequent behavior and to update our predictions during the event. While we may not be able to globally predict in detail the subsequent dynamic behavior, we can provide actionable forecasts for satellite operators on a few key event characteristics: a. Time to most severe environment b. Most severe Flux reached c. Time to the end of event These characteristics were deemed most useful by spacecraft operator representatives at ESWW16 [http://www.stce.be/esww13/contributions/public/S5-O1/S5-O1-03-PitchfordDave/FORECASTINGTHEPERFECTSTORM.ppt]. We overcome the data-assimilation nowcast limitations by using physics based models driven by simple, affordable and reliable ground-based real-time inputs only, we overcome our inability to accurately forecast magnetospheric drivers by using a scenario-driven forecast approach for RB dynamics starting with nowcast and is constantly refined during an event by the ongoing availability of real-time model inputs

Keywords: protection of assets in and from space,space security,space weather,space situational awareness,typical scenario forecast,radiation belt,real time ground based drivers,spacecraft operators
Memory and Populism from Below (MEMPOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1492268.0
EU funding (EUR): 1492268.0
Participants: 1
Project status: SIGNED

Political polarisation with rising support for populist movements is one of the most pressing global issues that we are facing worldwide. Yet, it is usually Central and Eastern Europe that are singled out for examples of unprecedented resurgences of populism, illiberal nationalism, and increasingly authoritarian forms of government. However, considering how divergent the so-called populist regimes of Central and Eastern Europe are, as well as the types of mnemonic populism they employ, ‘populism’ has become a label that is as empty as it is fashionable. To scrutinise the notion of Central and Eastern European populism and provide a novel perspective on this phenomenon, the project proposes a radical shift from the two units of analysis that are taken for granted in populism studies: the temporal unit that presumes Central and Eastern European populism is a post-socialist consequence; and the geographical unit that essentialises contemporary nation-states of Central and Eastern Europe. By adopting a bottom-up approach and investigating the everyday mnemonic practices and populist sentiments of ordinary people living in the transnational borderland periphery, namely, Burgenland, Galicia, Istria, and Silesia, this pioneering study moves away from the elite, top-down investigation of populism as well as the tendency to treat the state as the primary unit of analysis. Instead, it shifts the centre of focus to the post-imperial transnational borderlands where, in fact, both antagonistic memories and support for populist movements are arguably the strongest.

Keywords: collective memory,populism,transnational borderlands,political anthropology,ethnography,central and eastern europe
Enabling Unobtrusive Real-World Monitoring of Brain-Networks with Wearable Neurotechnology and Multimodal Machine Learning (INTEGRAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1654850.0
EU funding (EUR): 1654850.0
Participants: 1
Project status: SIGNED

Measuring and linking brain network activity to human physiology and behavior in natural everyday situations promises profound new insights into healthy brain function and disorders. However, the absence of suitable mobile neurotechnology presents a significant roadblock. Functional magnetic resonance imaging (fMRI) has greatly advanced our understanding of brain function and networks, but it is limited to single-snapshot experiments in constrained lab settings. Electroencephalography (EEG), while mobile, cannot directly be linked to brain networks captured by fMRI. To overcome these roadblocks and to advance neuro-inspired treatments and discoveries to natural environments, a hybrid wearable platform is required that combines innovations in hardware and analysis methods to enable continuous and stable measurements of brain network activity maps in the everyday world. Advancing high-density diffuse optical tomography (HD-DOT) can provide such a suitable alternative to fMRI. With a unique systems engineering concept, INTEGRAL aims to miniaturize and integrate DOT, EEG, and physiological sensors with advanced multimodal machine learning to improve spatio-temporal contrast in mobile brain-imaging. To this end, Objective 1 (Instruments) will develop hardware for unobtrusive and continuous wearable brain-body imaging with HD-DOT-EEG. Objective 2 (Experiments) will collect extensive multimodal data for measuring brain networks while controlling for environmental and physiological artifacts. Objective 3 (Analysis) will enable estimation of brain network activity with multimodal sensor fusion and machine learning and Objective 4 (Integration) will provide validation of robust brain-networks imaging in ecologically valid everyday world environments. If successful, this new platform will provide unprecedented opportunities to study brain function with global impact on neurotechnology applications and research from Neuroscience of the Everyday World to digital health.

Keywords: functional near infrared spectroscopy,fnirs,diffuse optical tomography,dot,multimodal signal processing,multimodal machine learning,electroencephalography,physiological sensors,neuroimaging,wearables,brain networks,neuroscience of the everyday world
IMPROVing lifElong health and development for children and adults born very PRETERM – observational studies to enhance randomised trials for comparative effectiveness research (IMPROVE PRETERM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,United Kingdom,Norway,Germany,Portugal,Sweden,Denmark,Belgium,Italy,Estonia,Finland,Poland,Switzerland
Call: Comparative effectiveness research for healthcare interventions in areas of high public health need (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7873924.44
EU funding (EUR): 7668747.89
Participants: 20
Project status: SIGNED

IMPROVE PRETERM aims to optimise the discovery and use of cost-effective, affordable and accessible interventions at birth and in early childhood to mitigate the adverse consequences of very preterm birth (VPT; <32 weeks of gestation). These include cerebral palsy, motor and cognitive impairment, visual/auditory deficits, respiratory illnesses, and psychiatric disorders and affect lifelong health and wellbeing. The VPT population is of high public health need as long-term outcomes are not improving despite increased survival, due to logistic and ethical challenges in generating evidence on effective interventions, leading to unstandardised and suboptimal care. Multidisciplinary, geographically diverse (13 country) research teams, working with key stakeholders (families, patients, health professionals and policymakers) will leverage advances in causal inference methods and optimise existing data sources (trials, cohort studies, birth registers, neonatal networks) within an established European federated platform for Comparative Effectiveness Research (CER). Use Cases will compare high-priority interventions: 1) antenatal and postnatal corticosteroid treatment, 2) follow-up and intervention programmes and 3) vaccine strategies. Capacity-building outputs will be: 1) a generalisable Lifecourse CER Framework (core outcome sets, methodological guidelines for causal inference and economic evaluation); 2) an open-source validated and standardised parent-report tool for assessing child development; 3) data sources (>30) and analytic methods on a sustainable, privacy-preserving FAIR platform. IMPROVE PRETERM will consider a broad range of patient-valued outcomes, extending current assessment periods beyond infancy, to provide holistic, cost-effective solutions for high-quality CER. Outputs will improve the use of evidence-based care by clinicians and policymakers, reduce the preventable health burden and promote better quality of life for VPT individuals and their families.

Keywords: very preterm birth,neonatal intensive care,neurodevelopment,comparative effectivness research,patient valued outcomes,causal inference,observationnal data
Climate-resilient management for safe disinfected and non-disinfected water supply systems (SafeCREW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Netherlands,Spain,United Kingdom,Ukraine
Call: Securing drinking water quality by protecting water sources against pollution, providing innovative monitoring and treatment solutions and ensuring safe distribution (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 4186197.5
EU funding (EUR): 4186197.25
Participants: 12
Project status: SIGNED

Safe and affordable supply of drinking water (DW) in the EU under the pressure of climate change is a key priority. Despite long-term experience with the reliable operation of disinfected and non-disinfected drinking water supply systems (DWSS), a number of challenges around microbial stability, the (future) need for disinfection and the consequences of disinfection by-products (DBPs) formation for human health remain open, directly deriving from climate change impacts such as increasing water temperature and higher levels of natural organic matter (NOM). SafeCREW aims to support the novel EU DW Directive by generating advanced knowledge and developing tools and guidelines for disinfected and non-disinfected DWSS and addresses improved comprehensive water quality characterization, novel treatment solutions to actively respond to identified threats, and the management of distribution networks to avoid water quality deterioration up to consumers. Novel data sets on the occurrence and concentration of so far unknown DBPs will be created, and commercial actors stimulated to further develop tools for DBP quantification and mitigation. Transferable tools will be provided to end-users (water utilities, national/EU regulators, researchers, SMEs), including: (I) reliable methods to evaluate microbial stability, characterise NOM, detect DBPs and account for DBP human health toxicity, (II) protocols to select proper materials in contact with disinfected water, (III) monitoring and modelling tools, also exploiting machine learning, for real-time optimisation of DWSS management, and (IV) an integrated risk assessment framework to guide future interventions which ensure that both disinfected and non-disinfected DWSS can continue providing safe DW in the face of climate change. SafeCREW will increase the preparedness of the EU water sector to challenges arising from climate change and will support the EU’s leading position in science-based policy making for DW consumer protection.
m4mining: Multi-scale, Multi-sensor Mapping and dynamic Monitoring for sustainable extraction and safe closure in Mining environments (m4mining)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Norway,Germany,Sweden,Cyprus,Greece,Australia,Switzerland
Call: Earth observation technologies for the mining life cycle in support of EU autonomy and transition to a climate-neutral economy (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4696629.74
EU funding (EUR): 4499512.13
Participants: 9
Project status: SIGNED

The m4mining project aims to provide an integrated remote sensing approach for mapping and monitoring active and inactive mining sites. Hyper- and multispectral imaging combined with 3D surface measurement will be utilised for material identification from the detailed mine face to the site scale using unmanned aerial vehicles (UAVs) and satellite sensors. Central to the proposed work is a synergistic unification of UAV and satellite-based processing algorithms, workflows and decision-making tools at timescales required to impact active operations and environmental and risk management of tailings and waste sites. A novel UAV system will combine hyperspectral, lidar, navigation, on-board computing systems and telemetry to acquire high-resolution oblique datasets from mine faces and tailings. Key innovations will be dynamic processing of spectral and lidar data, communicating initial results to on-site users, allowing interactive presentation and decision-making while the UAV is in flight. In addition, high quality results be rapidly available for integration with site-scale satellite workflows and enhanced classification algorithms. This combined approach offers a step-change in active mine operations and tailings management, paving the way for novel products and services. New applications include improved sorting of material during extraction, material quality assessment, re-mining of secondary raw materials, as well as monitoring environmental impact. m4mining will contribute to reduced energy consumption through faster response times for mine operators and will impact digitalisation of mining. The main result will be technology validation in operational environments: three sites in EU and key EU raw materials import markets will be used, in Cyprus, Greece and Australia. The project consortium is established from internationally leading commercial hardware and software providers, research groups in technology and applications in mining, and public stakeholders.

Keywords: hyperspectral,drone,lidar,real time,visualisation,satellite,tailings,mine face,data fusion,geology,risk
Driving inclusive care: economic democracy and social economy (DICES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Belgium,Ireland,Bulgaria,Norway,Greece,Germany,Austria
Call: The role of social economy in addressing social exclusion, providing quality jobs and greater sustainability (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3438252.5
EU funding (EUR): 3438252.5
Participants: 10
Project status: SIGNED

Social economy organisations play a crucial role in tackling social exclusion. However, the development of social economy governance frameworks and their impact on social inclusion remains insufficiently explored. The DICES project aims to bridge this gap with a threefold objective: (i) Enhance understanding of Europe's social economy and identify factors driving its uneven development; (ii) Evaluate the role of social economy organisations in addressing social exclusion and improving services and workplaces; (iii) Recommend policy measures and governance frameworks to unlock the social economy's potential, including strategies for identifying and promoting best practices. DICES, first, establishes a conceptual and empirical framework and conducts a mapping, examining the social economy's integration into welfare governance frameworks. Second, DICES uses 'deep dives' to investigate contributions at local, including in left behind places, and organisational levels, including in the provision of care. This work builds on case studies and pilot actions, a survey, small-scale experiments and other innovative methods. This approach is connected through the identification of conditions that would allow organisational experiments to scale up into institutional experiments. DICES uses interdisciplinary methods across EU and non-EU countries. The project engages stakeholders through co-design of pilot actions and peer review cycles, complementing quantitative and qualitative studies. Stakeholder input helps develop concrete policy proposals. DICES disseminates findings through research papers policy briefs, a digital storyboard, webinars, and toolboxes for policymakers and practitioners to maximise impact on policymakers, stakeholders, and the public.

Keywords: social inclusion,social economy,economic democracy,left behind places,care sector,inclusive care,governance frameworks,welfare states
ContraBand: the only heart failure medical device that is placed outside the heart (Contraband)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 3850718.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Worldwide 26 million people suffer from Congestive Heart Failure (CHF), a chronic condition that worsens with time and leads to staggering healthcare costs and a significant reduction of quality of life. ContraBand is an implantable device aiming to restore heart function in patient suffering from left ventricle failure. ContraBand’s benefits include built-in fail-safe for full reversibility of functionality, tremendous ease of use due to its proprietary stеnt-within-a-stеnt design and transcatheter delivery system, and full clinical flexibility to be compatible with pharmacotherapies and other CHF devices. In the project, we will finalise clinical development and introduce ContraBand into clinical routines in Europe. We expect to launch ContraBand in 2024, generate €15M in revenues in 2025 and €60M in 2026. Before market launch, we will create >95 jobs at the company in strategic locations in Europe.

Keywords: congestive heart failure