Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ThrombUS+: Wearable Continuous Point-of-Care Monitoring, Risk Estimation and Prevention for Deep Vein Thrombosis (ThrombUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Greece,Lithuania,France,Germany,United States,Italy,Finland,Spain
Call: Harnessing the potential of real-time data analysis and secure Point-of-Care computing for the benefit of person-centred health and care delivery (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 9565763.75
EU funding (EUR): 8141251.25
Participants: 18
Project status: SIGNED

Deep vein thrombosis (DVT) is the formation of a blood clot within the deep veins, most commonly those of the lower limbs, causing obstruction of blood flow. In 50% of people with DVT, the clot eventually breaks off and travels to the lung to cause pulmonary embolism. Clinical assessment of DVT is notoriously unreliable because up to 2/3 of DVT episodes are clinically silent and patients are symptom free even when pulmonary embolism has developed. Early diagnosis of DVT is crucial and despite the progress made in ultrasound imaging and plethysmography techniques, there is a need for new methods to enable continuous monitoring DVT diagnosis at the point of care. ThrombUS+ brings together an interdisciplinary team of industrial, technology, regulatory, social science and clinical trial experts to develop a novel wearable diagnostic device for point-of-care, operator free, continuous monitoring in patients with high DVT risk. The device will combine autonomous, AI driven DVT detection based on a novel wearable ultrasound hardware, impedance plethysmography and light reflection rheography for immediate detection of blood clot formation in the lower limb. Activity and other physiological measurements will be used to provide a continuous assessment of DVT risk and support DVT prevention via serious gaming. The aggregated data will drive an intelligence decision support unit that will provide accurate monitoring and alerts. Extended reality will be used to guide experts to design exercises and patients to use the device optimally. ThrombUS+ is intended for use by postoperative patients in the ward, during long surgical operations, cancer patients or otherwise bedridden patients at home or in care units, and women during pregnancy and postpartum. ThrombUS+ will use big data sets for AI training collected in the project via 3 large scale clinical studies and will validate the outcome in the clinical setting via 1 early feasibility study and 1 multi-center clinical trial.

Keywords: deep vein thrombosis detection,deep vein thrombosis risk estimation,artificial intelligence,smart wearables,smart garments,body sensor networks,extended reality,serious games
Eco-evolutionary dynamics in urban ponds under artificial light at night (ECO-EVO ALAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Artificial light at night (ALAN) is a ubiquitous feature of urbanization, and increases globally. Recent work, mainly conducted on terrestrial systems, reveals negative biological impacts of ALAN. If experienced in aquatic systems, ALAN may disrupt the delicate food web dynamics in urban ponds, with potentially detrimental consequences such as the occurrence of (toxic) algal blooms, which can cause serious harm to animals, including humans. Zooplankton, key components of freshwater systems, exert strong control over algal growth, but this crucially depends on their diel vertical migration (DVM) patterns (i.e. migrating to the bottom during day, and to the surface during night) – a dynamic known to be disrupted by ALAN. To date, very little is known about potential evolutionary adaptations in response to ALAN, whereas is has never been studied whether such adaptations can shape the ecology of ponds, e.g. top-down control of algae (so-called ‘eco-evolutionary feedbacks’). With the proposed project, I aim to study whether i) ALAN influences trait distributions and DVM of water flea zooplankton communities in urban ponds, ii) water fleas originating from these ponds have evolved genetic adaptations to ALAN in key ecologically relevant traits, and iii) ALAN-driven genetic trait changes influence the ecology of urban ponds (i.e. top-down control of algae). To achieve these aims, I will conduct a comprehensive field study, followed by laboratory common-garden experiments with ALAN-manipulation, and finally a field transplant DVM experiment. By integrating these results within an eco-evolutionary modelling framework, I will test for ecological consequences of evolutionary adaptations in one or multiple water flea species to ALAN. Given the rapid rate of urbanization, findings of the proposed research will be highly relevant in predicting the often-complex effects of (evolution towards) global change on ecosystems, with direct socioecological and socioeconomic consequences.

Keywords: urbanization,eco evolutionary dynamics,urban evolution,light pollution,ecosystem services,common garden,zooplankton community,top down control,food webs,daphnia,urban ponds,urban ecology
Visitor monitoring and management in protected and recreational areas: new challenges, novel solutions for the Anthropocene (VIMAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Denmark,Finland,Iceland,Latvia,France,United States,Sweden,Germany
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 2892664.8
EU funding (EUR): 2892664.8
Participants: 21
Project status: SIGNED

Visitor management of protected and recreational areas in the Anthropocene Loved by many, practised by even more. Recreation in the outdoors provides large benefits to individuals and societies, but with increased participation also follows challenges with sustainable management of nature areas. VIMAS’ primary objective is to develop more efficient governance of nature areas for tourism and recreation, in the best way possible for biodiversity, people’s quality of life and business development. This will be achieved through research about smarter monitoring methods, improved visitor management and more inclusive governance. Recreation in the outdoors has transformed in several ways; besides the increase in volume of visitors, the behaviour of visitors has diversified; visitors partake in a wider set of activities, visit more remote places, take more diversified trips in nature, have different motivations for visitation as well as levels of experience and skills. New monitoring and management tools honed for the Anthropocene must address the cumulative social and ecological impacts from increased tourism and recreation while striking a balance with ethics, privacy, and equal opportunities. To do this successfully, VIMAS focuses on novel monitoring techniques based on digital data developed and tested in the Nordic-Baltic region to address the contemporary challenges of increased demand, socio-economic inequality, and uncertain climate futures. The innovations of VIMAS are to realise potential from new knowledge developed in the intersection between quantitative and qualitative social sciences, ecology, and geo-informatics technology based on inclusive approaches for non-agency stakeholders and citizens. Through this, VIMAS will develop new, effective evidence-based tools towards smart governance and planning for recreational and protected natural areas for the next generation, optimising the delivery of public health, community well-being, business success as well as other ecosystem services while protecting environmental values.

Keywords: tourism,recreation,protected areas
RENEWABLE METHANOL-BASED SYNTHETIC MULTIFUEL PRODUCTION (METHCESFUEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Germany
Call: Development of next generation synthetic renewable fuel technologies (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 3996062.5
EU funding (EUR): 3996062.5
Participants: 10
Project status: SIGNED

The METHCESFUEL project pioneers next-generation synthetic renewable fuel technologies, contributing to Europe’s climate neutrality, energy security, and industrial resilience. By integrating carbon capture, green hydrogen, and thermochemical energy storage (TCES), the project enables the cost-effective production of drop-in fuels, including renewable methanol, synthetic methane, and dimethyl ether (DME). The project contributes to replace fossil fuels in transport, power generation, and industrial applications, utilizing existing infrastructure and ensuring energy system stability. The project directly addresses the REPowerEU strategy by reducing dependency on Russian fossil fuels, diversifying Europe’s gas supply, and enhancing energy storage solutions. By leveraging renewable energy inputs such as solar, wind, and biomass-derived hydrogen, METHCESFUEL ensures carbon-neutral fuel production, effectively mitigating greenhouse gas (GHG) emissions. The project also strengthens Europe’s open strategic autonomy by driving cutting-edge digital process optimization, multi-scale system modelling, and advanced catalysis, increasing conversion efficiencies and economic viability. The innovation builds on a three-step conversion system: (1) Green methanol production from CO2 and hydrogen, (2) Methanol-to-syngas conversion, and (3) Syngas transformation into methane and DME, integrating high-temperature heat recovery to improve overall system efficiency. This TRL4 laboratory-scale demonstrator will validate feasibility, scalability, and sustainability, laying the foundation for industrial-scale deployment. By integrating renewable fuels with smart grids, carbon markets, and flexible energy systems, METHCESFUEL accelerates the EU’s green and digital transition. It reinforces Europe’s leadership in sustainable fuel technologies, ensuring a resilient, decarbonized energy future while enabling economic growth and sectoral transformation.
Timing of Early Solar System Isotopic Evolution: Resolving Temporal Discrepancies and Isotopic Variability in Chondrules through Multi-Element Analysis (TESSIE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

This project aims to resolve longstanding uncertainties in the early solar system’s history by analyzing chondrules—millimeter-sized particles found in meteorites. Chondrules, formed in the protoplanetary disk that surrounded the young Sun, hold key insights into early solar system evolution and planetary formation. However, discrepancies in the dating of these objects using different chronometric systems have led to debates about their formation timeline. This research will employ high-precision isotope analysis of magnesium, silicon, and chromium in chondrules from both inner and outer solar system meteorites. By examining mass-independent isotopic heterogeneity, the project seeks to refine our understanding of the conditions and processes that shaped the early solar system, ultimately enhancing astrophysical models of mass distribution and migration within the protoplanetary disk.

Keywords: cosmochemistry,isotopes,solar system evolution,meteorites,mass transport,chondrule formation
Genetically anchored drug target discovery for neglected diseases (GenDrug)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1498089.0
EU funding (EUR): 1498089.0
Participants: 1
Project status: SIGNED

There are thousands of common non-communicable diseases (NCDs) that lack safe and effective drugs despite accounting for most health care expenses and years lived with disability. Me and my team will address this unmet clinical need by developing innovative algorithms that generate and integrate evidence from massive scale genomic studies with real-world data based on millions of patients from electronic health records (EHRs) to identify potent drug targets and opportunities for drug repurposing. To achieve this aim, we will 1) harness ethnically diverse biobanks (>500,000 participants) with whole-exome/genome sequencing and EHR linkage powered by deep learning models to gain new insights into the aetiology of neglected NCDs that are needed for rational drug design, 2) create a genetically anchored biomedical knowledge graph that incorporates rich functional genomic data from single-cell studies with drug characteristics to predict promising drug targets using deep graph neural networks, and 3) establish convergence of genetic and real-world evidence of proposed drug targets by emulating clinical trials in multiple large EHR datasets (>50 million patients). Unique access to diverse hospital cohorts and a clinical trial unit at one of the largest European hospitals, the Charité Universitätsmedizin Berlin, will further accelerate clinical translation for selected examples. With GenDrug, we aim to build a community resource to enable and accelerate drug development using ‘big data’ for hundreds to thousands of diseases that currently lack safe and effective treatments.

Keywords: causal inference,electronic health records,drug repurposing
Hormone-microbiome interactions as a key-player in female health (HEROINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1499485.0
EU funding (EUR): 1499485.0
Participants: 1
Project status: SIGNED

Incidence rates of inflammatory and autoimmune diseases are increasing dramatically and a clear sex bias exists in disease presentation and progression. While the underlying reasons are largely unknown, hormones are hypothesized to play a central role in these discrepancies and the microbiome is linked to disease pathology. However, a key understudied player is the interplay between hormones and the microbiome in human health. Crucially, hormone-microbiome interactions in the human body are poorly understood. Microbes produce hormone-like signals and play a role in hormone metabolism and regulation, while hormones influence bacterial growth. It is currently unknown how the menstrual cycle impacts the microbiome and how disruptions of this natural cycle impact female health. I have identified unique fluctuations in microbial diversity in healthy women that are absent in men and altered in women on hormonal contraceptives. There is a lack of medical research focusing on female physiology, particularly investigating endocrinological changes and disruptions. Understanding the consequences of endocrine-related disruptions and how hormone-microbiome interactions contribute to them is a fundamental step towards precision medicine that will benefit both women and men. Therefore, I will systematically investigate hormone-microbiome interactions in (1) healthy women on and off hormonal contraceptives, (2) women at menopause and (3) infertile women receiving fertility treatment. I will integrate clinical data with state-of-the-art multi-omics profiles using computational approaches and I will combine these with mechanistic validation using bacterial strains isolated from the female subjects. At the end of my project, we will know how exogenous and endogenous hormones interact with the microbiome and how they impact female health. Further, we will identify biomarkers for optimal treatment of infertility and propose new microbiome-based therapeutic strategies for this disorder.

Keywords: microbiome
Regulation of hormone-sensitive lipase in neurons (RELINEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Several lipids and lipid-derived molecules play crucial roles in regulating brain function, affecting synaptic activity and plasticity, cerebral blood flow regulation, and neuroinflammatory processes. Outside of the central nervous system, the hormone-sensitive lipase (HSL) mediates the actions of catecholamines, glucagon, and insulin on lipolysis. While HSL is present in the brain, its role in brain lipid metabolism remains unknown. Recent findings from the host lab demonstrate that HSL is abundant in neurons and enriched in synapses. Additionally, genetic deletion of HSL in mice leads to memory impairment when exposed to aging or metabolic stress (e.g., high-fat diet feeding). Suggested mechanisms by which HSL deletion leads to brain dysfunction include the production of eicosanoids and endocannabinoids, and control over energy metabolism and neurovascular coupling. However, the mechanisms regulating HSL activity in neurons remain unknown. We propose here that HSL is a relay between neuronal activity and the production of bioactive lipids that control brain physiology. This pioneering project aims to explore the physiological regulation of neuronal HSL and its neurophysiological implications in neuronal cells. The research will be conducted at Lund University, supervised by Dr. João Duarte, combining his expertise in brain metabolism and behavior with my background in biochemistry and cell biology. This project holds immense potential for advancing our understanding of brain lipid regulation and its relevance to brain function.

Keywords: neurochemistry,cell signaling,bioactive lipids
End-of-Life MAGnet Recycling for an EU INdependent Economy (EMAGINE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Greece
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

EMAGINE commercialises a breakthrough circular solution for the recovery and reuse of rare earth elements (REEs) from end-of-life (EoL) permanent magnets - primarily NdFeB and SmCo - used in emerging applications such as electric vehicles, wind turbines, and electronic devices. Europe currently depends on imports for over 98% of its REE materials and respective magnet supply, predominantly from China, exposing its green and digital transitions to major supply and geopolitical risks. Moreover, current European recycling initiatives have limited capacity and production rates, producing rare earth oxides that require energy-intensive reprocessing to reach magnet-grade quality. EMAGINE disrupts this landscape by deploying the first industrial-scale, zero-waste, hydrometallurgical process capable of directly producing six high-value, magnet-grade alloys and oxides from multiple waste streams. The process achieves over 95% recovery yields, reduces CO2 emissions of magnet making by 77% compared to using materials coming from primary mining, and eliminates hazardous waste generation. Having reached TRL 7, the project aims to upscale its pilot facility to TRL 8 and beyond, achieving full-scale production with the recycling of 615 tn of EoL permanent magnets per year to produce 433 tn/year of magnet precursors. Under this capacity, the project will become a strategic supplier of sustainable magnetic materials to European OEMs, including STELLANTIS and MAGNETI Ljubliana. Commercial agreements have been reached with both OEMs for the supply of permanent magnet materials. EMAGINE’s innovation combines cost efficiency, modular scalability, and sustainability, offering at least 15% price reduction over commercial materials. The initiative supports EU strategic goals under the Green Deal, Critical Raw Materials Act (2023), and Net Zero Industry Act (2024) by strengthening regional autonomy, industrial competitiveness, and clean-tech manufacturing capacity.

Keywords: permanent magnets,sustainability,recycling,rare earths,hydrometallurgy