Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Euro-Argo ERIC scaling up for OneArgo Network Extension (Euro-Argo ONE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: France,Germany,Italy,Denmark,Finland,Greece,Spain,Norway,Bulgaria,Poland,Netherlands,United Kingdom
Call: Consolidation of the RI landscape – Individual support for evolution, long term sustainability and emerging needs of pan-European research infrastructures (HORIZON-INFRA-2024-DEV-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4998288.75
EU funding (EUR): 3998631.0
Participants: 23
Project status: SIGNED

OneArgo is the new global, full-depth and multidisciplinary design of the International Argo Programme, the most prominent global in situ ocean observing network. OneArgo will advance climate change and ocean health research capabilities. Furthermore, by allowing more complete and accurate ocean and climate projections, OneArgo will strengthen the potential of operational users to deliver services for the monitoring, adaptation and mitigation of climate change, including at policy level. The Euro-Argo ONE project will allow Euro-Argo ERIC, the legal and organisational framework supporting and coordinating the European contribution to the Argo programme, to align with the OneArgo ambition. Its overarching objective is scale-up Euro-Argo ERIC’s capabilities, sustainability and resilience to ensure Europe’s ability to take its share of the global OneArgo array implementation. To this end, the 23 partners of Euro-Argo ONE will: - Tailor a comprehensive design of OneArgo for its European implementation; - Escalate Euro-Argo ERIC’s efficacy in delivering OneArgo data and services; - Address the environmental challenges of OneArgo operations and engage with the supplier industry; - Improve OneArgo products and services and maximise their impact for operational users and broader scientific communities; - Consolidate Euro-Argo ERIC leadership and collaborations within the international and European ocean observation landscape; and, - Demonstrate and promote the value of OneArgo for societal challenges. Euro-Argo ONE will considerably accelerate the consolidation of Euro-Argo ERIC, thereby allowing the research infrastructure to deliver on its mission to develop a long-term, sustainable European contribution to the OneArgo global ocean monitoring system, to better understand and predict the ocean, its role in the climate system and its health.

Keywords: ocean observations,oneargo,eric,climate change,ocean health
In situ structural biology of human immune defence (InSituImmuno)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1976553.0
EU funding (EUR): 1976553.0
Participants: 1
Project status: SIGNED

Structural biology provides insights into protein function but generally requires purified complexes, which necessitates removing the protein from its native context. We therefore lose in situ information. Cryo-electron tomography (cryoET) provides this information, but finding a specific protein in a cell is akin to searching for a needle in a haystack 50 m tall. We are at the forefront of developing a technique to solve this problem; by combining super-resolution (SR) light microscopy on samples prepared for cryoET we can locate specific proteins and events within whole mammalian cells. This information can be correlated with 3D cryoET volumes to perform in situ structural biology. We call this technique super-resolution cryo-correlative light and electron microscopy (SRcryoCLEM). Here, I describe how we will enhance SRcryoCLEM and use it to image antibody-activated aspects of human immunity, enabling the development of cutting-edge immunotherapeutics. The first aim of this proposal is to augment SRcryoCLEM with multicolour imaging and automated data analysis. Spectrally-distinct fluorescent proteins will be identified that are ideal for cryoSR imaging, and AI-based volume segmentation and automated particle picking will help to democratise in situ structural biology. The second aim is to deliver in situ structural data to explain discrepancies in antibody effector functions with an unknown structural cause, which will be used to perform structure guided antibody design to further enhance their effector functions for the benefit of human health. The third aim is to discover the structural determinants orchestrating antibody-mediated phagocytosis by macrophages using SRcryoCLEM. This immunologically-pivotal mechanism is poorly understood, but is being exploited as a next-generation therapeutic. Our data will provide crucial insights into the fundamental biological processes underlying macrophage function, allowing therapeutic gain.

Keywords: cryoem,in situ structural biology,cryo microscopy,correlative microscopy,clem
Diaminodicyanoanthroquinodimethanes: Electrically driven molecular micromotors (electorsDDADM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

Electric field-powered Micro/Nano motors (e-MNMs) are tiny devices that convert electric energy into mechanical movements. e-MNMs are the potential candidates for the range of applications from physics to biology. Most of the existing e-MNMs have been shown to propel in various fuel media, like H2O2, hydrazine, and hydroquinone, limiting their toxicity applications. The majority of their fabrication processes are expensive, time-consuming, and complicated, highlighting the need for a simple fabrication approach to devise eco-friendly e-MNMs. This proposal aims to develop a new strategy for fabricating electric field responsive asymmetric molecular microparticles using a simple fabrication technique and analyzing their motions in the presence of the electric field without an additional fuel medium. For the first time, we will employ the simple ‘reprecipitation technique’ to incorporate the gold nanoparticles into the asymmetric crystals of strongly zwitterionic diaminodicyanoanthroquinodimethane (DDADM) derivatives and employ them as micromotors under the electric field. The essential determinants for developing asymmetric morphologies will be a non-centrosymmetric assembly of dipolar molecules, non-equilibrium conditions, and local supersaturation during the reprecipitation technique; further examples will need to establish it conclusively. Molecular e-MNMs will be expected to exhibit high-speed motions (~ 30 to 100 times of the body length S-1) under a low electric field (50-180 V/cm). It will be proposed that the concentration gradient of the polar DDADM molecules and trapped gold nanoparticles across the asymmetric crystal can induce charge dielectrophoresis force in the presence of an electric field that could facilitate the mechanical motions of e-MNMs in the water. An empirical model will be developed for the mechanistic understanding of the actuation process and insight into the response of the DDADM molecules under the electric field.

Keywords: aggregation induced emission,zwitterionic,colloids,asymmetric particles,molecular micromotors,electric field,
Inhibiting resistance to immunotherapy in Oncology by targeting Netrin-1 (ImmunoNet)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-09-01
End date: 2025-09-30
Duration (months): 37.0
Total project cost (EUR): 8327233.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Immune Checkpoint Inhibitors (ICPIs) have recently revolutionized the treatment and management of cancer. Yet, progress recorded and impact on long-term survival affect only a limited fraction of patients, as most of the cancer patients do not or incompletely respond to ICPIs due to primary or secondary resistance to these treatments. NETRIS Pharma is an innovative biotech company based in Lyon. The company has developed NP137, a humanized monoclonal antibody targeting NETRIN-1, able to drive tumor growth inhibition and alleviate resistance to ICPIs, both impacts already confirmed in preclinical models. The objective of the IMMUNONET project is to conduct a proof-of-efficacy clinical trial assessing the efficacy of NP137 to alleviate suspected resistance to ICPIs. The increased response rate to ICPIs with NP137 would have a major impact on patients having limited treatment options beyond immunotherapies and create significant growth opportunities for NETRIS.

Keywords: immune resistance,immuno therapy,immune check point inhibitors,solid tumors,dependence receptors,humanized monoclonal antibody,clinical trial
Ultra-sensitive Field-resolved Infrared Spectroscopy for Early Disease Detection (UFRISED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Early detection is one of the most effective ways to improve the survival rate for diseases like cancer. However, current diagnoses often rely on invasive procedures and specialized tests, posing challenges for regular monitoring. Field-resolved infrared spectroscopy, which probes the "molecular fingerprint" of human blood, has achieved remarkable detection sensitivity by combining ultrafast laser technology with electric-field infrared detection. Despite its potential, the technique has yet to meet the stringent requirements of early screening, including single nanogram per millilitre sensitivity, 10^12 dynamic range, and long-term stability. The proposed project — 'Ultra-sensitive field-resolved infrared spectroscopy for early disease detection' aims to overcome these challenges by developing a ground-breaking instrument for field-resolved infrared fingerprinting of human blood plasma samples and demonstrate its performance for health monitoring. In particular, the researcher intends to develop: (i) a multi-kHz delay scanning system based on two Cr:ZnS lasers, synchronized down to single-femtosecond timing precision which aims to record measurements faster than most laser noise contributions, (ii) super-octave-spanning field-resolved infrared detection with a dynamic range exceeding 10^12, and (iii) an ultra-rapid referencing scheme that simultaneously records reference infrared electric fields with the measurement to realize standardization of the infrared molecular fingerprints and the long-term reproducibility. By addressing these limitations, the project will achieve unprecedented levels of sensitivity, dynamic range and stability. It provides an avenue for analyzing serum and plasma samples across a wide range of individuals and time frames, potentially uncovering spectral markers for different diseases. The system will be a minimally invasive and cost-effective method of early disease detection to improve patient prognosis and overall healthcare outcomes.

Keywords: field resolved infrared spectroscopy,early disease detection,ultrafast laser,electro optic sampling,molecular fingerprint
Relational Harm: Targeting the Family in War and Oppression (Relational harm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1990933.0
EU funding (EUR): 1990933.0
Participants: 1
Project status: SIGNED

This project will examine the novel concept of ‘relational harm’ (defined in the project as harm that individuals and communities experience through the targeting and control of their intimate relationships). The project will focus on ‘forced separation’ as a specific and topical manifestation of relational harm. While existing research has examined the specific vulnerability of children on their own and the long-term impact of familial separation on minors, little has been written about the experience and impact of forced separation on families and communities left behind. Additionally, less is known about why states carry out forced separation and how and why states target the family during war and counter-insurgency. This interdisciplinary and mixed methods project will map state practices of forced separation and the targeting of youth. It will anchor relational harm in a range of historical contexts and will conduct archival research on longer-standing cases of forced separation and reunification, particularly during the Second World War. Examining the case studies of Sri Lanka, the Rohingya (living in Bangladesh), and Peru, the project will focus on the political, social, and economic legacies of familial separation and the lived everyday experiences and consequences of ‘ambiguous loss’. The project will study the extent to which evolving international law and transitional justice practices address relational harms and forced separation. It will examine legal frameworks on the right to family and family life in relation to forced separation. The project will focus on gendered aspects and legacies of relational harm. Engaging with a wide multidisciplinary literature, the project will examine family as both a realm of meaning and security and as a site of vulnerability and harm. The project will make a significant contribution through its critical examination of family and family life as fundamental to the waging and experience of war.

Keywords: harm,separation,war,youth,displacement,law
Evolutionary Origins of Cognition in Crocodiles (EvOCRO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,Mexico
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 2
Project status: SIGNED

Crocodiles, known to be dangerous predators with powerful jaws and agile inhabitants of aquatic environments, may hide surprisingly high cognitive abilities. Previous studies have revealed that crocodiles can learn quickly and have effective short-term memory, strong spatial memory and cognitive flexibility in communication. However, these insights remain sporadic, hampered by the logistical challenges of their remote habitats, financial constraints, and less public and scientific interest than more charismatic species. With the support of the Marie Skłodowska-Curie Actions programme, EvOCRO aims to change the game by proposing these reptiles as a non-traditional model species to explore their cognitive abilities in more detail. This project seeks to understand the evolution of cognitive plasticity by studying crocodile cognition at different life stages, considering individual differences and comparing it with other species. By integrating methodologies from behavioural ecology, comparative psychology, animal cognition and evolutionary biology, EvOCRO will provide a holistic understanding of crocodile cognition. The project involves a major collaboration with Mexican research institutions, leading to an interdisciplinary approach to advance scientific knowledge and real-world applications in conservation strategies and animal welfare. Among the key aspects of EvOCRO we find not only the communication of results through publications and conferences to involve the scientific community but also the participation in public awareness events and conferences to engage and educate the wider community. EvOCRO sheds light on the cognitive abilities of crocodiles, aiming to provide valuable insights into cognitive evolution and inform conservation efforts by highlighting the importance, impact and timeliness of this research.

Keywords: animal cognition,reptiles,crocodiles behaviour,individual differences,personality,ontogeny,learning,cognition
Occurrence, Regulation, and Function of Bacterial mRNA Editing Under Diverse Environments (REDBAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1749998.0
EU funding (EUR): 1749998.0
Participants: 1
Project status: SIGNED

Bacteria are haploid, having a single copy of each gene. We suggest a paradigm shift in bacterial genetics: bacteria can have two RNA versions of the same gene, encoding protein isoforms at the single-bacterium and population level. These protein isoforms can have altered activity, which could be advantageous under different conditions. Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and the function of translated proteins because the ribosome identifies inosine as guanosine. We discovered that A-to-I mRNA editing occurs in bacteria (Escherichia coli), identified the mediating enzyme, and showed that it could affect protein function. Moreover, we discovered that environmental cues experienced during growth in culture affect bacterial mRNA editing. However, the prevalence and regulation of A-to-I mRNA editing across bacteria and the importance of editing for protein function and bacterial physiology in different environments are still unknown. Here, we will test the hypothesis that mRNA editing is widespread in bacteria, producing two RNA "alleles" (pseudo-heterozygosity). Subsequently, these RNA "alleles" may co-exist in the same bacterial cell or population of cells. Thus, mRNA editing may enable the translation of protein isoforms, making bacteria better adapted to changing environments. We suggest (1) identifying mRNA editing events across environmental conditions in hundreds of species, (2) uncovering the regulatory genetic factors governing bacterial mRNA editing occurrence, and (3) determining the effect of mRNA editing on the proteome and its functional role in bacteria. Our work could shed light on a new mechanism bacteria employ to grow and survive in different environments. Furthermore, bacterial mRNA editing—invisible to DNA sequencing—may account for unsolved problems or phenomena that current genetic and proteomic data cannot explain, affecting bacterial biology and human health.

Keywords: rna editing,trna editing,inosine,tada,bacteria
Diagnosing Infections with Multi-Drug Resistant Microorganisms using AI-powered Genomic Antibiotic Susceptibility Prediction from Long-Read Sequencing Data (DRAIGON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Germany,Netherlands,Austria,Albania,Switzerland,United States,United Kingdom
Call: Pandemic preparedness and response: In vitro diagnostic devices to tackle cross-border health threats (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6522484.25
EU funding (EUR): 6348099.88
Participants: 9
Project status: SIGNED

The silent pandemic of antimicrobial resistance (AMR) is a growing global health crisis with a projected annual mortality rate of 10 million by 2050. Addressing this crisis critically depends on fast, accessible and precise diagnostics to improve detection and prevention of infection and guide antibiotic therapy. Current diagnostics often have insufficient turnaround time or data for timely detection and prevention of outbreaks or precision antibiotic therapy guidance, and accessibility is often limited due to the required infrastructure and expert personnel. To overcome these shortcomings, and address AMR, we are developing a diagnostic based on accelerated whole genome sequencing linked with AI-assisted data analysis. This project termed “DRAIGON” includes a consortium of internationally recognized experts in sequencing platform and assay development, bioinformatics and machine learning, clinical microbiology, infection prevention and control, antibiotic therapy and stewardship, and health economics to jointly develop our in vitro diagnostic solution to target virtually any pathogen-antibiotic combination. We propose to validate and demonstrate the clinical utility of DRAIGON focusing on bloodstream and prosthetic joint infections at five independent sites, including one located in a medium income country representative of areas with a high AMR burden and reduced access to laboratory infrastructure. The diagnostic will be easy to implement and functions as an early detection system to prevent the cross-border spread of pathogens. In rapidly and accurately providing pathogen ID and type, a comprehensive antibiogram, and outbreak cluster information directly from genome data and in a single assay, this innovative high-resolution diagnostic aims to reinforce the global fight against AMR infections and enable the antibiotic stewardship goals of “right antibiotic, at the right dose, for the right patient, and at the right time”.

Keywords: whole genome sequencing wgs pathogen detection,antimicrobial resistance amr antibiotic susceptibility testing ast bloodstream infections prosthetic joint infections,artificial intelligence