Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Catalytic cascade reactions. From fundamentals of nanozymes to applications based on gas-diffusion electrodes (CASCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-05-31
Duration (months): 69.0
Total project cost (EUR): 2499462.0
EU funding (EUR): 2499462.0
Participants: 1
Project status: SIGNED

Nanoparticles with etched substrate channels are proposed as a simplified enzyme mimic, nanozymes, for electrocatalysis providing concave catalytically active sites together with the local modulation of electrolyte composition. This concept will be extended to bimetallic core-shell structures with etched channels to provide locally confined catalyst surfaces with varying selectivity. The first catalytic reaction at the channel entrance selectively generates a product, which is further converted in a follow-up reaction catalysed at the core material at the bottom of the channel. The endeavour to locally assemble catalysts with different properties in nano-confined reaction volumes to actualise cascade reaction pathways will be extended to layered nanoparticle structures. Together with an anisotropic provision of a gaseous reactant through a hydrophobic/hydrophilic phase boundary of specifically designed gas diffusion electrodes multi-step catalytic cascade reactions become feasible. The development and extensive evaluation of multi-catalyst gas-diffusion electrodes using operando electrochemistry/spectroscopy and nano-electrochemical tools as well as multi flow-through electrolysers will provide the fundamental knowledge concerning the relative location of different catalyst particles, which synergistically perform chemical cascade reaction with high selectivity and at high current densities. These gas-diffusion electrodes will be integrated in novel electrolyser concepts targeting CO2 recycling at high current density in alkaline solution under suppression of H2 competition with previously unprecedented selectivity for the formation of higher hydrocarbons envisioning contributions to a closed carbon cycle economy and a substantial decrease of CO2 emission. Additionally, a novel tree-type rotating electrolyser design is proposed for the removal of hazardous gaseous pollutants from air e.g. at street crossings in cities as exemplified by NOx reduction to N2 or NH3.

Keywords: electrocatalysis,nanoelectrochemistry,nanoparticles,etched nanoparticles,enzyme analogues,selectivity,substrate channel,gas diffusion electrodes,co2 reduction,nox reduction
Genomics, epigenomics and transcriptomics of Yakutian horses, a unique domestic breed adapted to life in the Arctic (YAKUT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-15
End date: 2017-09-14
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Yakutia (Sakha Republic, Russian Federation) is the coldest country in the Northern hemisphere with winter record temperatures as low as -70ºC. Despite such extreme conditions, the Yakut people succeeded in developing an economy based on extensive horse and cattle breeding. In contrast to cattle, that are parked in stables at winter, horses do not receive much human care, living all the year in the open air and grazing on vegetation that is under deep snow cover for 7-8 months. Unsurprisingly, Yakutian horses developed amazing adaptations to life in the cold Arctic, including exceptional hair densities for domestic horses and spectacular capacities for regulating their metabolism. The origin of Yakutian horses is controversial. In the YAKUT project, we will use cutting-edge genomic tools including genomics, transcriptomics and epigenomics, together with state-of-the-art methods in ancient DNA research, to reconstruct the evolutionary history of Yakutian horses from its mysterious origins to its adaptation to life in the Arctic. Our extensive genomic dataset will provide essential information to foster efforts for developing sound management strategies to preserve this unique genetic heritage. Following seasonal gene expression levels and associated epigenetic modifications at the whole genome scale, we will reveal for the first time the mechanisms responsible for the exceptional metabolic adaptations found in Yakutian horses. Overall, the YAKUT project aims at understanding the process of natural selection underlying the adaptation of a domestic breed to life in an extreme environment.

Keywords: palaeogenomics,ancient dna,horse,adaptation to cold
Co-Creating Misinformation-Resilient Societies (Co-Inform)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Spain,Cyprus,Greece,Sweden,United Kingdom,United Kingdom
Call: Policy-development in the age of big data: data-driven policy-making, policy-modelling and policy-implementation (H2020-SC6-CO-CREATION-2017, 2017)
Start date: 2018-04-01
End date: 2021-07-31
Duration (months): 40.0
Total project cost (EUR): 4110758.75
EU funding (EUR): 4110758.75
Participants: 12
Project status: CLOSED

Misinformation generates misperceptions, which have affected policies in many domains, including economy, health, environment, and foreign policy. Co-Inform is about empowering citizens, journalists, and policymakers with co-created socio-technical solutions, to increase resilience to misinformation, and to generate more informed behaviors and policies. The aim of Co-Inform is to co-create these solutions, with citizens, journalists, and policymakers, for (a) detecting and combating a variety of misinforming posts and articles on social media, (b) supporting, persuading, and nourishing misinformation-resilient behavior, (c) bridging between the public on social media, external fact checking journalists, and policymakers, (d) understanding and predicting which misinforming news and content are likely to spread across which parts of the network and demographic sectors, (e) infiltrating echo-chambers on social media, to expose confirmation-biased networks to different perceptions and corrective information, and (f) providing policymakers with advanced misinformation analysis to support their policy making process and validation. To achieve these goals, Co-Inform will bring together a multidisciplinary team of scientists and practitioners, to foster co-creational methodologies and practices for engaging stakeholders in combating misinformation posts and news articles, combined with advanced intelligent methods for misinformation detection, misinformation flow prediction, and real-time processing and measurement of crowds' acceptance or refusal of misinformation. Co-Inform tools and platform will be made freely available and open sourced to maximize benefit and reuse. Three main stakeholder groups will be directly engaged throughout this process; citizens, journalists, and policymakers.

Keywords: co creation,big data,policy making,misinformation,citizens,journalists,policymakers,resilience
Centre of Excellence in IT Science and Technology (InnoITeam)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Lithuania,Sweden,Sweden,Lithuania
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399167.5
EU funding (EUR): 399167.5
Participants: 5
Project status: CLOSED

To address and promote growth in several technological sectors in Lithuania and encourage EU teaming in ICT-related research and innovation, the overall objective of the project is to create a new Centre of Excellence (CoE) in IT Science and Technology for the Internet of Things and Smart Living Systems, which will be referred to as “InnoITeam”. The long-term vision for InnoITeam is to: ● Become the leading provider of innovative technologies for IoT and Big Data for the improvement of the growing technological personal and industry needs in Europe; ● Consolidate research and development, education and training, and networking and promotion resources activities in Information and Communications Technology (ICT); ● Coordinate, integrate and support research excellence and innovation development in Lithuania, the Baltic Sea region, and Europe; ● Support researchers, academics, industry partners and entrepreneurs in the field of ICT, particularly in IoT, to produce innovations beneficial for the society and economy of Lithuania and beyond. To achieve this long-term vision, the CoE will leverage the knowledge, experience and resources of three Lithuanian institutions – KTU, VGTU and SECR- with the support of two advanced EU partners from Sweden – LiU and TII – in four strategic research and innovation (R&D) topics: R&D Topic 1: User interfacing and interaction design approaches for Smart Environments based on IoT; R&D Topic 2: Cybersecurity aspects in the Smart Environments based on IoT; R&D Topic 3: Data analysis and visualization approaches for data intensive IoT environments; R&D Topic 4: Cognitive IoT technologies for Smart Home Environments. This project has the full support of the Lithuanian Government because it fits perfectly with several of the national priorities within the SMART Specialisation Strategy approved by the Government, and, will allow an enhanced usage and further growth of the recently upgraded infrastructure for ICT research in Lithuania.

Keywords: internet of things,human computer interaction,cyber security,privacy,data analysis,visualization,smart,home,environments,connected living,cognitive,artificial intelligence
Super-Resolution Imaging and Mapping of Epigenetic Modifications (SRIMEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Epigenetic marks are posttranslational modifications of chromatin that act as gene regulators. Although every cell-type contains the same DNA sequence, the epigenetic marks dictate specific function of each cell-type. Epigenetic modifications are both heritable and dynamic, and can be treated enzymatically to reverse. The dynamic marks sometimes lead to aberrant gene regulation in cells, causing diseases such as cancer, Alzheimer’s, and diabetes. Therefore, epigenetic state of individual genes can be used to identify the aberrant genes to reverse them. In this project, a novel assay for simultaneous identification of epigenetic marks and their genomic position is proposed. State-of-the-art DNA-PAINT super-resolution microscopy, developed by Prof. Jungmann, in combination with immunofluorescence in situ hybridization (iFISH) will be used to identify the epigenetic marks in human cells with very high precision (<5 nm). The novelty of this assay is that, for the first time, it will allow to read the epigenetic marks, their genomic and 3D position in the nucleus simultaneously, for precise mapping of the epigenetic state of genes in individual cells. The assay can be used as a tool to identify aberrant marks in cells for diagnosing diseases caused by these modifications. Therefore, it has a high potential for both research in biotechnology and diagnostics.

Keywords: epigenetics,dna paint,super resolution imaging,fluorescence,dna origami,chromatin
On-chip optical communication with transformation optics (CHIPTRANSFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-06-01
End date: 2019-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Transformation optics grew out of ideas for invisibility cloaking and exploits connections between electromagnetism in media and in geometries. This Proof of Concept project uses transformation optics for improving on-chip optical communication in silicon photonics. The goal is reaching a performance that matches industry standards such that the idea becomes sufficiently convincing to be commercialized.

Keywords: silicon photonics,transformation optics,electronics
Defect Simulation and Material Growth of III-V Nanostructures- European Industrial Doctorate Program (DESIGN-EID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 878988.96
EU funding (EUR): 878988.96
Participants: 3
Project status: SIGNED

In semiconductor technology and applications today, we are increasingly observing a shift from the pure silicon CMOS technology towards hybridisation of function in terms of bringing in sensors, power, memory and photonics functionality on the same chip. In particular, there is a great interest in the heterogeneous and monolithic integration of III-V materials and other complex semiconductors, such as III-Nitrides and SiC on Si substrate. However, the direct growth of III-V materials on silicon inevitably will lead to crystal defects that significantly decreases performance of novel devices. To overcome this main technological challenge and to make this new technology financially viable, the most cost-effective and time-effective approach is to combine experimental and simulation work, which indeed is the main aim on this project – DESING-EID. This will be achieved by addressing the following objectives. The first objective of DESIGN-EID is to train three young ESRs who will bridge the gap between predictive simulations, experimental materials and device development by developing simulation tools for prediction of crystal growth as a function of process conditions. Secondly, completely eliminating defects in compound semiconductors is likely not achievable, therefore a simulation framework providing an accurate evaluation of their impact on device performance will be essential for designing devices and materials minimizing their impact. Furthermore, semiconductor defects in semiconductors may be exploited for their unique electronic properties if their presence and properties are controlled. For example, vacancies might be used to implement Qu-bits, whereas extended defects, such as dislocations, can provide unique transport properties. Hence, the last objective of the DESIGN-EID project focuses on experimental control and accurate simulation of the impact of defects on electronic and photonic device performance.

Keywords: material growth,iii v materials,semiconductors,device modelling,material simulations,electronics,optoelectronics
Custom-designed gene editing of induced epidermal stem cells for gene therapy of genetic diseases of squamous epithelia (Holo-GT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Italy
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2462375.0
EU funding (EUR): 2243125.0
Participants: 3
Project status: SIGNED

Holo-GT will define innovative ex vivo gene therapy of dominant genetic skin disease, by using Epidermolysis Bullosa (EB) as a model system. EB is a group of dominantly or recessively inherited, devastating, incurable diseases marked by structural fragility of the integuments. The applicant has shown that combined ex vivo cell and gene therapy can cure the skin of recessive LAMB3-Junctional EB. This lifesaving procedure unveiled that the human epidermis is sustained solely by long-lived stem cells, detected as holoclone-forming cells, which generate transient progenitors referred to as meroclones and paraclones. However, over 50% of EB are dominantly inherited, making gene addition unsuitable. Gene editing does not efficiently correct epidermal stem cells, which define a small proportion of clonogenic keratinocytes and cannot be prospectively isolated. Holo-GT aims at designing a safe and efficacious protocol for dominant forms of EB through: • Molecular characterization of the keratinocyte clonal types and pathways sustaining holoclone-forming cells by single-cell RNA profiling. • Generation of induced holoclone-forming cells (iHolo) by transient expression of specific sets of transcription factors (identified in aim 1) able to reprogram progenitors into holoclone-forming cells. • Development of custom-engineered CRISPR/Cas nucleases, based on selection-based directed evolution or structure-guided mutagenesis, able to fully distinguish wild type and mutant alleles. • Using this newly developed CRISPR/Cas system, gene editing of iHolo prepared from keratinocyte cultures initiated from patients with dominant forms of EB. Holo-GT could tackle not only dominant EBs but also other dominant genetic diseases of the epidermis and other squamous epithelia, as well as recessive forms of EB, particularly those characterized by the well-known depletion of stem cells, which could be rescued by the reprogramming of transient progenitors into holoclone-forming cells (iHolo).

Keywords: epidermal stem cells,regenerative medicine,cell therapy,gene therapy,gene editing,genetic skin diseases,epidermolysis bullosa
Square Kilometre Array: Infrastructure Detailed Design for SKA Phase 1 (IN-SKA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Australia,South Africa,United Kingdom
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2016-01-01
End date: 2018-02-28
Duration (months): 26.0
Total project cost (EUR): 4955475.0
EU funding (EUR): 4955475.0
Participants: 4
Project status: SIGNED

The Square Kilometre Array (SKA) is an international project to construct the largest and most sensitive radio telescope ever conceived. The SKA will use hundreds of thousands of radio telescopes receivers, in three unique configurations, which will enable astronomers to monitor the sky in unprecedented detail and survey the entire sky thousands of times faster than any system currently in existence. The SKA telescopes will be co-located in Africa and in Australia. South Africa’s Karoo desert will cover the core of the high and mid frequencies of the radio spectrum which will have telescopes spread all over the continent, with Australia’s Murchison region covering the low frequency range and hosting the survey instrument. The objective of the IN-SKA proposal is to support the implementation of the SKA, enabling the start of construction in 2018 and delivery of first science around 2020. To achieve this, the proposal plans to provide resources to complete the Detailed Design of the core SKA Infrastructure required in South Africa and Australia. The proposed programme will address the design of roads and civil works, power distribution to run the telescope and supporting computing facilities, antenna foundations and the specialist design of new buildings; buildings that will be suitable for maintaining a pristine radio-quiet environment needed to ensure that SKA is able to achieve its science goals. In addition to driving innovation in many areas, and supporting the SKA as an inspirational vehicle for skills, industry and outreach, the ultimate deliverables of tender documentation ready for construction will place European and other national industry in leading positions to benefit directly from implementation of the SKA in 2018.

Keywords: radio telescope,astronomy,astrophysics,esfri,infrastructure,big data