Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional and structural studies of the U12-dependent splicing in human cells (MinorSplice)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1479277.0
EU funding (EUR): 1479277.0
Participants: 1
Project status: SIGNED

Introns are non-coding segment of eukaryotic genes, which are removed from precursors of messenger RNAs (pre-mRNAs) by a large and dynamic RNA-protein complex known as the spliceosome. In human cells, most of the introns are processed by the canonical U2-dependent, major spliceosome. Around 0.5% of human introns utilise an alternative splicing pathway, catalysed by the minor spliceosome, which depends on the U12 small nuclear RNA (snRNA). While U12-dependent introns are rare, often they are located in genes with critical cellular functions and mutations in the minor spliceosome components lead to several genetic disorders. MinorSplice project aims to perform a comprehensive structural and functional characterization of the U12-dependent splicing pathway. The functional studies will be focused on the proteomic characterization of the minor spliceosome assembly intermediates and the involvement of the conserved spliceosomal RNA helicases in the U12-dependent splicing pathway. By combining cell-based assays, proteomics and next generation sequencing methods we will create a detailed picture of the minor spliceosome composition and associated regulatory mechanisms. The core of the projects aims to determine a series of minor spliceosome’s structures using single particle electron cryo microscopy (cryo-EM). We expect that high-resolution structural information will answer some of the fundamental mechanistic questions about the minor spliceosome assembly, U12-dependent intron recognition and will shed a light on structural similarities and differences between the major and minor splicing pathways. The last part of the project will aim to visualise spliceosomes in the native cellular environment using electron cryo tomography (cryo-ET). By doing so, we anticipate to obtain functional insights into the coupling between different nuclear processes.

Keywords: pre mrna splicing,minor spliceosome,snrnp,helicase,cryo em
Societal Attitudes to Urban Novel Ecosystems (NovelEco)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999941.0
EU funding (EUR): 1999941.0
Participants: 1
Project status: SIGNED

Novel ecosystems are unmanaged wild areas that are anthropogenic in composition and can never be restored to their original ecological status. Though relatively new, novel ecosystem theory challenges our fundamental relationships with ‘new’ nature and what this means for the future of biodiversity conservation and societal progress. This has resulted in much polarised debate among the ecology community where novel ecosystem theory is highly contested, but there has been no engagement with human communities on the implications of novel ecosystems. The aim of NovelEco is explore novel ecosystem theory as a bridging concept and a conduit for rewilding urban society. NovelEco will be a shift in theoretical exploration and will redefine ‘new’ nature, and how it may be perceived and valued. Urban novel ecosystems have been chosen because they are the most likely spaces where many citizens will encounter what appears to be ‘wild’ nature, particularly people and communities with little financial resources to visit wild nature in a remote setting. Indeed, we know little of the implications of novel wild nature in urban communities. NovelEco is a citizen science project that will measure for the first time the societal attitudes to urban wild spaces by asking citizens to study them. It will first of all engage citizens in co-creating an online instrument to enable ecological data collection within urban novel ecosystems. During data collection the citizen scientists will also record their attitudes to novel ecosystems and reveal whether engagement with them alters their values and perhaps even their environmental behaviour. Comparing these data with the wider community this project will be the first to quantify the social and ecological values of novel ecosystems. NovelEco will refine and redefine the novel ecosystem concept and create a new awareness of the transformative potential of urban wild spaces.

Keywords: novel ecosystems,rewilding,attitudes,citizen science
Non-coding RNA and Intercellular Communication in Cardiac Ageing (NICCA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1999690.0
EU funding (EUR): 1999690.0
Participants: 1
Project status: SIGNED

Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. The main clinical presentation of age-induced cardiovascular disease is heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease involving different cell types and mechanisms that contribute to impaired relaxation of cardiomyocytes. Currently there is no appropriate treatment for HFpEF. This proposal aims to better understand the molecular mechanisms behind intercellular communication and ageing that lead to HFpEF. Long non-coding RNAs (lncRNAs) are emerging as novel key regulators of cellular functions and we hypothesize that lncRNAs contribute to ageing-induced cardiac dysfunction, including HFpEF. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are differentially regulated during cardiac ageing, including the cardiomyocyte-enriched lncRNA Sarrah that is essential for cardiomyocyte survival. We propose to extensively characterize the role of Sarrah in HFpEF and to identify other lncRNAs that are involved in cardiac ageing. Importantly, we will focus those lncRNAs that are also affected in a cohort of human HFpEF patients. Furthermore, since disturbed intercellular communication is a hallmark of both ageing and HFpEF, we will identify lncRNAs that regulate endothelial cell-cardiomyocyte crosstalk. We will use state-of-the-art in vitro and in vivo models to assess cardiac ageing and function upon gain-of-function and loss-of-function of lncRNAs in a cell-type specific manner. Understanding the role that Sarrah and other lncRNAs play in cardiac ageing and HFpEF will highlight novel potential therapeutic targets to attenuate age-induced cardiac dysfunction and will increase our knowledge of the underlying mechanisms controlling intercellular communication and cardiac function.
Social Influence and Disruptive Low Carbon Innovations (SILCI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-05-31
Duration (months): 57.0
Total project cost (EUR): 1198136.0
EU funding (EUR): 1198136.0
Participants: 1
Project status: CLOSED

A low carbon transition requires disruptive innovations to challenge prevailing technologies and practices. Many disruptive low carbon innovations have been adopted, but in small numbers. Examples include car sharing networks, car-free communities, and net zero energy buildings. To mitigate climate change, these and other innovations must diffuse or spread into the mass market. In the absence of strong policy incentives, social communication from adopters to non-adopters is the means by which innovations spread. But we do not understand how the different mechanisms of social influence work for disruptive low carbon innovations, and whether they can be harnessed to accelerate change. In this project, I aim to address this critical knowledge gap by asking: what role can social influence play in driving the diffusion of disruptive innovations as part of a low carbon transition? This project will open up a new scientific field on disruptive low carbon innovations using rigorous scientific methods applied to a wide range of novel data. Objective 1. To understand the attributes of disruptive low carbon innovations valued by actual and potential users. -> By using secondary data, structured elicitation exercises, and a large-scale cross-national survey, I will evaluate innovation attributes and their potential acceptability to mass market adopters. Objective 2. To assess the strength and mechanisms of social influence in the diffusion of disruptive low carbon innovations. -> By analysing social network structures, online activity, and the spatial distribution of early adopters, I will quantify the relative strength of social influence in diffusion processes. Objective 3. To test strategies and actions for using social influence to accelerate a low carbon transition. -> By modelling social influence effects in global climate mitigation models, I will test the effectiveness of long-term strategies and actionable policies for accelerating low carbon transitions.

Keywords: energy transitions,disruptive innovations,social influence
Establishing a Multi-purpose Biorefinery for the Recycling of the organic content of AHP waste in a Circular Economy Domain (EMBRACED)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Spain,Italy,Italy,Germany,Spain,Italy,Italy,Switzerland,Croatia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Valorisation of the organic content of Municipal Solid Waste and contributing to the renewable circular economy (H2020-BBI-JTI-2016, 2016)
Start date: 2017-06-01
End date: 2022-12-31
Duration (months): 67.0
Total project cost (EUR): 15821700.0
EU funding (EUR): 10494611.74
Participants: 18
Project status: CLOSED

A sizeable category in terms of organic content within MSW is represented by Absorbent Hygiene Products (AHPs; e.g. nappies, adult incontinence products, feminine hygiene items, wipes, etc.) waste, which is currently considered as non-recyclable fraction of MSW and finds its way to landfills or incineration, leading to important environmental concerns. Indeed, each year 8,500,000 tons of such waste are incinerated or landfilled in Europe (the equivalent of almost 30 landfills every year), and over 30,000,000 tons in the world. AHP are mainly composed of a mix of natural fibres (cellulose) and polymers (PP/PE and superabsorbent polymer), valuable materials that currently don’t find a proper valorization. Within EMBRACED project, a first-of-its-kind multi-purpose integrated biorefinery will be established in order to valorize in a relevant environment scenario the cellulosic fractions obtained from AHP waste towards the production of bio-products of significant commercial interest, and – concurrently – high added-value co-products, such polyolefinic plastics and SAP (superabsorbent polymers). This innovative biorefinery model will involve all the main actors of the whole value chain, from AHP consumers and local population to waste management and logistic companies, leading AHP producers and bioprocess developers, as well as final products developers. In a view of circular economy, all the fractions obtained from the processed AHP waste will be reused through valorization into final products, and in particular the high-quality cellulosic fraction of AHP (ca. 1,275,000 ton/y in Europe), which has significant advantages vs. traditional 2nd generation lignocellulosic feedstocks in terms of homogeneity and downstream bioprocessing costs, will be converted and valorized in two parallel value chains, leading to the production of biobased building blocks, polymers and fertilizers.

Keywords: multi purpose biorefinery,circular economy,post consumer absorbent hygiene products waste
INNOVATIVE AND DISRUPTIVE DRY-VERMICOMPOSTING TOILET CONCEIVED FOR EU STOREYS BUILDINGS (SANIBUILDING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today, sanitation systems at western countries are based on flushing toilets and its subsequent treatment of waste waters. This method implies a huge amount of water used per person as well as a lot of energy that is used for waste water treatment plants. This method does not always comply with the standards, polluting soils and watercourses. On top, the extension of Europe dry regions could increase to 26% if the average temperature rises 2 degrees Celsius. New flushing toilets incorporating less litres at their tank still don’t solve the problem. For the reasons expressed above, new approaches of feces and urine management at urban level need to be considered in order to ensure natural areas’ preservation, improve water/energy management and reduce its consumption. Dry toilets are a part of the solution, but most of them are conceived for individual houses or isolated cabins but not for storey buildings. In response, SANISPHERE, a French SME leader at dry toilets with a patented urine and feces separation system and composting method based on earthworms created SANIBUILDING, an unique method able to be used at storey buildings no matter the number of storey, with a negligible use of water and electricity with the possibility to transform feces in high quality compost used for gardening, with a very easy maintenance. SANIBUILDING project aims to finalise now its technical development and market preparation. To achieve these objectives first we need to prepare a Feasibility Study that help us warrant our project from all technical, financial and commercial points of view. This study will allow us to set the plan to push our technology forward, from TRL6 to TRL9. Once completed, this project will bring key advantages to society and the environment while boosting the growth of our company. Indeed, we estimate to gain €5.7 million in profits and reach a ROI of €3 from this project after 5 years, with a positive impact regarding employments with 31 job creation.

Keywords: sanitation systems,toilets,treatment,waste waters,energy,polluting soils,feces,urine,dry toilets,management
ORganic thermoelectric GEnerators to power precision VIticulture sensor NEtworks (ORGEVINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-02-01
End date: 2022-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

ORGEVINE aims to reduce water and phytosanitary chemicals usage as well as enhancing production yield in the wine industry by developing a network of wireless autonomous sensors that will provide real time images of key field parameters such as temperature and humidity. This will be achieved by taking our patented non-toxic thermoelectric materials into prototype organic thermoelectric generators (OTEGs) that will power the low-cost sensors. By taking advantage of the ubiquitous renewable energy source that is the temperature difference between soil and air, the sensors will become self-powered, thus avoiding a major bottleneck in the Internet of Things, i.e. the costly battery replacement. This interdisciplinary project will constitute a key enabling step in the broad field of precision agriculture, as well as environment conservation (e.g. through forestry fire prevention).

Keywords: organic thermoelectrics,self powered sensors,precision agriculture,renewable energy,viticulture
Automatic Design of Robot Swarms (DEMIURGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The scope of this project is the automatic design of robot swarms. Swarm robotics is an appealing approach to the coordination of large groups of robots. Up to now, robot swarms have been designed via some labor-intensive process. My goal is to advance the state of the art in swarm robotics by developing the DEMIURGE: an intelligent system that is able to design and realize robot swarms in a totally integrated and automatic way The DEMIURGE is a novel concept. Starting from requirements expressed in a specification language that I will define, the DEMIURGE will design all aspects of a robot swarm - hardware and control software. The DEMIURGE will cast a design problem into an optimization problem and will tackle it in a computation-intensive way. In this project, I will study different control software structures, optimization algorithms, ways to specify requirements, validation protocols, on-line adaptation mechanisms and techniques for re-design at run time.

Keywords: swarm robotics,automatic design
Cities Cooperating for Circular Economy (FORCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Germany,Italy,Portugal,Denmark,Denmark,Denmark,Denmark,Denmark
Call: Eco-innovative solutions (H2020-WASTE-2015-two-stage, 2015)
Start date: 2016-09-01
End date: 2021-02-28
Duration (months): 54.0
Total project cost (EUR): 10840530.0
EU funding (EUR): 9724969.129999999
Participants: 24
Project status: CLOSED

The overall objective is to minimise the leakage of materials from the linear economy and work towards a circular economy. Specific objectives are to: • Engage cities, enterprises, citizens and academia in 16 participatory value chain based partnerships to create and develop eco-innovative solutions together. • Develop 10 viable end-markets by demonstrating new applications for plastic waste, metals (EEE devices), biowaste and wood waste. • Develop a governance model for cities based on value chain based partnerships. • Develop decision support tools and assess the actual impact by use of Big Data. • Ensure replication through the FORCE Academy aiming at enterprises, citizens and policy makers. The eco-innovative solutions will be demonstrated across four cities (Copenhagen, Hamburg, Lisbon and Genoa) and using the four materials: Flexible plastics: Recycling and upgrade of 5,000 tonnes of flexible plastic from enterprises and private households will enable virgin material substitution, corresponding to preventing emissions of 12,500 tonnes of CO2. Metals: Citizens will be mobilised to reclaim an additional 2 kg/capita of WEEE (app. 3,600 tonnes). A communication campaign will reach 100,000 citizens and support at least five SME’s that repair damaged EEE devices so that 10-20% of the collected WEEE can be redistributed. Wood waste: additional 12,000 tonnes wood waste from urban and mountain areas will be collected. 8-10,000 tonnes of brushwood will be used for compost production, and 14-16,000 tonnes will be processed into wood particles. Biowaste: around 7,000 tonnes of biowaste from the municipal mixed waste stream will be recovered: 3,000 tonnes coming from restaurants and hotels, and 4,000 tonnes coming from households. The partnerships will result in the creation of viable eco-innovative market solutions, exploited by the partners. Replication in other cities will be incentivised thus ensuring competitiveness of European Circular Economy and green growth.

Keywords: circular economy,partnerships,value chain,end markets,governance models,big data,metals from electronic and electrical equipment,plastic waste,wood waste,biowaste