Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the role of microbiome-fibroblast crosstalk in intestinal immune development, homeostasis and inflammation (FibroBiomeCrosstalk)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

The microbiome plays an essential role in intestinal immune development, homeostasis and inflammatory bowel diseases (IBD), however, our understanding of the underlying mechanisms by which it regulates these processes remains incomplete. Intestinal fibroblasts (iFB) are a heterogeneous population of tissue-resident cells increasingly recognized for their role in immune regulation. In preliminary studies, the host group and a collaborator found that human and mouse iFB express distinct arrays of microbial sensors and immune mediators and that iFB transcription is altered in germ-free mice. In my proposed project, I will combine state-of-the-art high dimensional flow cytometry, single cell (sc)RNA-seq, CITE-seq, spatial transcriptomics and bioinformatics analysis with animal models and analysis of human intestinal datasets to test the hypothesis that microbiome-iFB crosstalk plays a key role in intestinal immune system development, homeostasis and inflammation. Microbiome impact on iFB and intestinal immune system development will be assessed throughout the weaning period by treating mice with broad-spectrum antibiotics and/or antifungals. The importance of direct iFB-microbiome sensing for immune homeostasis and inflammation will be assessed as above as well as in dextran sulphate sodium (DSS)-induced colitis model in mice whose FB are deficient in either the Toll-like receptor signaling adaptor Myd88 or the C-type lectin receptor-Syk mediated antifungal response adaptor CARD9. Finally, translational aspects will be assessed through extensive bioinformatics analysis of iFB scRNA-seq datasets to map microbial sensor expression in human iFB subsets, evidence of downstream signaling through such sensors and their alterations in IBD. Collectively, this project uses a multi-systems approach to obtain novel insights into the importance of microbiome-iFB interactions in intestinal immune system homeostasis and disease with potential relevance for IBD management.

Keywords: gut microbiome fungi immune system development connective tissue inflammatory bowel diseases gene expression
Housing Precarity Pathways, Meanings, Influences and Responses among South Asian Migrants to Dublin (HOUSING PRECARITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-09-30
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Housing affordability and homelessness have been persistent problems both for Irish nationals and migrants over the last decade, but these problems are particularly acute among the latter. With the exception of those who are seeking asylum in Ireland, non-EEA migrants’ housing challenges have been largely ignored by policymakers in this country. The housing situation of non-EEA migrants has also received little attention from researchers and the factors which shape their particular housing problems are not well understood. In particular neither the interaction between housing precarity and other socio-economic precarities which are more common among migrants (e.g. relating to labour market discrimination or legal status) has not been explored in depth, nor have migrants’ responses to these challenges and their agency in trying to shape pathways through these precarities. This research will fill these critical knowledge gaps by examining South Asian migrants’ lived experiences of housing precarity in Dublin, Ireland’s capital and largest city. The project aims to investigate South Asian migrants’ to Dublin lived experience of precariousness in terms of housing, labour market activity and immigration status and the interaction between these. The project marries the concepts of housing precarity, multiple precarities and structure-agency integration to guide a ground-breaking, multi-method anthropological study of these migrants’ precarity. This innovative analytical framework goes well beyond the current state-of-the-art and has the potential to illuminate the precarity pathways of other marginalised groups in Ireland and internationally. By employing mixed methods (quantitative and qualitative), this project will examine the interaction between housing-related structures and migrants’ everyday agency and the role this plays in shaping their access to affordable and suitable homes and housing precarity.

Keywords: housing precarity pathways,south asian migrants,structure agency,dublin
Innovating Sediment Oxygen Consumption Quantification: A Novel Proxy Utilizing Marine Bacterial Tetraether Lipids (SOCGDGT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Marine sediments serve as Earth's primary repository for organic matter, playing a pivotal role in the global carbon and oxygen cycles. Sediment oxygen consumption (SOC) is a key metric for assessing the degradation and preservation of sedimentary organic matter and for gauging the activity levels of benthic communities. However, current methods for measuring SOC face limitations, notably their reliance on specialized, costly instrumentation and their lack of applicability in geological contexts. Here, we propose a novel, lipid-based approach for quantifying SOC using branched glycerol dialkyl glycerol tetraethers (brGDGTs). These bacterial membrane lipids have been extensively used in paleoclimate reconstructions. Recent advances highlight the widespread production of brGDGTs by benthic marine bacteria and the significant role of oxygen in brGDGT production and distribution. Our preliminary data indicate strong correlations between brGDGTs and SOC, hinting at a potential tool for assessing SOC in both modern and paleo marine sediments. To thoroughly address the scientific question, "How can brGDGTs be used to assess modern and paleo SOC?" this proposal sets forth to: 1) establish a robust, quantitative proxy for SOC by rigorously investigating the linkage between brGDGTs and SOC, utilizing multidisciplinary methodologies encompassing biomarker lipids, oxygen microprofiles, microbial communities, and geochemical analyses in geographically diverse sediments; 2) evaluate the proxy’s effectiveness and limitations through laboratory incubations; and 3) assess the proxy’s applicability for paleo SOC reconstructions. This research will broaden our knowledge of the ecophysiological behaviours of marine brGDGT-producing bacteria, enhance the precision of brGDGT applications in paleoclimate reconstructions, and pioneer an innovative molecular proxy for SOC quantification across diverse spatiotemporal scales.

Keywords: biogeochemistry,marine sediment,sediment oxygen consumption,brgdgts,quantitative proxy
Novel microsensing platform for remote patient monitoring (FORESEE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2499051.25
EU funding (EUR): 2499051.25
Participants: 1
Project status: SIGNED

We have developed and in-human validated a new generation of implantable microstimulators for neuroprosthetics, accomplishing very thin (< 1 mm) and flexible devices with an unprecedented level of miniaturization as they lack batteries and bulky components. Our microstimulators are powered by an external system using an innovative wireless power transfer method that uses the human body as an electrical conductor of innocuous high frequency currents. While developing the microstimulators, we realized that this technology could also be used to create minimally invasive implants capable of sensing relevant biomedical parameters for remote patient monitoring (RPM). Our technology has the potential to revolutionize RPM, as it allows to combine different sensing capabilities in a single device and to create a network of implants for multi-site sensing. After analysing several opportunities, we decided to focus the applicability of our sensing platform to chronic heart failure (HF) monitoring. Chronic HF is a long-term, persistent condition in which the heart is not able to efficiently pump blood to the body, causing symptoms such as limited physical activity and swelling. With time, the patient decompensates, leading to repeated costly hospitalizations with an annual cost of caring of US$30,000 per patient in US, and a 5-years mortality rate of 50%. RPM using implanted sensors is an emerging clinical reality for HF patients, as it optimizes medical management and treatment, improving their quality of life and outcomes. The objective of FORESEE is to bring the implantable microsensing platform for RPM of HF patients from TRL3 up to completion of TRL5, and to develop a successful business strategy to ensure its future market access, benefiting almost 10.5 million HF patients in EU and US that are candidates for RPM. The technological and business activities developed by our team with strong scientific and business expertise will ensure tech-to-market transition.

Keywords: implantable medical device,pulmonary artery pressure,remote patient monitoring,miniaturized sensor,heart failure,cardiovascular diseases,aimd
Functionalized porous organic cages for adsorption and photodegradation of per- and polyfluoroalkyl substances (PFAS) (PhotoClean)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Increasing energy consumption, depletion of natural resources, and environmental pollution are nowadays among the biggest economic and social challenges. Per- and polyfluoroalkyl substances (PFAS), also known as forever chemicals, are persistent emerging pollutants not naturally degraded in the environment. PFAS are anthropogenic compounds with harmful health effects, inert and resistant to heat, and nowadays found in water, air, and soil, thus posing a heavy impact on our environment. Adsorption on activated carbon, ion-exchange resins, cyclodextrins, and nanofiltration are the methods currently used or under study for PFAS removal from water. However, critical gaps, such as the adsorbent regeneration, affinity, production of secondary waste, analytical method limitations, and efficient PFAS degradation pathways are major challenges. PhotoClean aims to synthesize novel palladium functionalized, solvent-responsive nanocage adsorbents able to remove PFAS from water. The nanocages will promote rapid PFAS photodegradation, being excited by visible-light to a photoexcited state able to interact with PFAS through a single electron transfer. Depending on the energy of the photoexcited state, PFAS decomposition is expected to be initiated either through oxidative or reductive events and be sustained by the formation of radicals. The new approach proposed by PhotoClean is based on the development of reusable adsorbent cages and the exploitation of visible-light as the energy source to activate PFAS decomposition; it thus constitutes an environmentally sustainable strategy for PFAS removal and degradation. The project will contribute to understand fundamental structure-property relationships of PFAS adsorption on nanoporous organic cages and integrate photodegradation of PFAS with catalytic activity. The action has the potential to revolutionize methods for PFAS removal from water and tackles a variety of scientific and societal challenges of environmental importance.

Keywords: per and polyfluoroalkyl substances,porous organic cages,water pollution,adsorption kinetics,adsorption isotherms,photocatalysis,photodegradation,decomposition
Doctoral Network on Energy Geostructures Integration: Buildings, Infrastructure and Underground Storage (GENIUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,France,Italy,Norway,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4809251.88
EU funding (EUR): 4809251.88
Participants: 21
Project status: SIGNED

GENIUS pioneers a comprehensive approach to address the biggest global challenge the energy sector is facing: the transition to renewable-based, energy-efficient heating and cooling systems. Space heating and cooling currently makes up the world's largest energy sector, accounting for approximately 50% of the final energy consumption. This figure is expected to grow rapidly over the coming decades due to economic and population growth, and inevitable increase in urbanisation. At the same time, the world is experiencing one of the most severe global energy crises in history, impacting the fossil fuels’ availability and cost. More than ever, there is an urgent need for innovative technologies to harvest renewable energy resources, to decrease our dependence on fossil fuels. Energy geostructures represent an effective means to meet the world request of less dependence on unsustainable resources by being designed as dual-purpose elements targeting geothermal heat exchange and structural support for buildings. Yet, their wider use has been hindered by the lack of (i) sustainable expertise pipeline in the field of energy geotechnology, (ii) technical knowledge regarding the integration of energy geostructures to buildings and infrastructure, (iii) scientific knowledge for the integration of energy geostructures with other underground structures. GENIUS will address all three challenges by developing advanced analysis and design tools for energy geostructures (WP-1) and by advancing practical and scientific knowledge for their integration with buildings, infrastructure and other energy resources (WP-2 and WP-3). Furthermore, the holistic approach of GENIUS will train the ESRs to become pioneering experts in conceptualization, design and implementation of energy geostructure applications. Networking with their peers, industry and stakeholders will give them highly attractive skills for transforming their ideas to implementation.

Keywords: geothermal energy,energy geostructures,thermal energy storage
Development of a new generation detailed hydrogen combustion mechanism (DCMH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Hungary
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 157622.4
EU funding (EUR): 157622.4
Participants: 1
Project status: SIGNED

The most promising carbonless fuels are hydrogen and H2/NH3 mixtures. Burners, reciprocating engines and gas turbines using these fuels can be designed by computational fluid dynamics (CFD) tools, provided that an accurate chemical submodel (detailed reaction mechanism) is available. A comprehensive collection of hydrogen combustion experimental data was created 10 years ago by the hosting laboratory and published on the ReSpecTh.hu website. The initial aim of the project is to extend this data collection with all newly published experimental data. Also, further types of laboratory measurement results, like extinction limits will be added to the database. Then, a new base chemical kinetics mechanism for hydrogen combustion is set up, that uses the latest directly measured and theoretically calculated rate coefficients of the H/O system, and also takes into account the newly proposed mechanistic approaches, like new third-body efficiency parameters and a non-linear mixing model for these parameters, new diffusion parameters, and reactive termolecular reactions. The base model will be optimized using the updated data collection. The base model, the optimized model and all recently published hydrogen combustion mechanisms will be tested together using the whole data collection. It is expected that the obtained new generation detailed hydrogen combustion mechanism will provide more accurate simulation results compared to the currently available ones, especially under problematic conditions like high pressure, lean combustion and high water vapour concentration in the initial mixture. This mechanism will be an important ingredient of the CFD design of devices using hydrogen and H2/NH3 and H2/natural gas fuel mixtures.

Keywords: hydrogen combustion detailed chemical kinetic mechanisms mechanism optimization database of experimental data
A Mesoscopic approach to Cross-diffusion Modelling in population dynamics (MesoCroMo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Cross-diffusion aims at modelling the influence of one species on the diffusion of another one and can be seen as an extension of the standard diffusion described by the Laplacian. It finds application in several fields like physics, chemistry and biology. Of particular interest in the literature is the macroscopic cross-diffusion Shigesada–Kawasaki–Teramoto (SKT) system which is considered the prototypical model to describe the dispersive movement of cross-interacting species in population dynamics, leading to the formation of spatial patterns (front invasions, segregation effects). Despite their importance and large use in the scientific community, their derivation from a mesoscopic formulation is still missing in the literature and the admissible ranges for the relevant macroscopic coefficients that would be needed for application purposes have not been yet identified. The novel challenge of MesoCroMo is to introduce new biologically meaningful multi-species Boltzmann-type models for competitive dynamics, obtain the first derivation of the SKT system from these kinetic equations in some suitable hydrodynamic limit, from a theoretical and a numerical point of view, and provide explicit relations for the cross-diffusion and reaction coefficients in terms of the mesoscopic parameters. This will be done by redesigning well-known tools and methods from the kinetic theory of reactive gases and creating an innovative bridge between the concept of relaxation to thermodynamic equilibrium for distribution functions in kinetic theory and that of quasi steady state approximation for fast-reaction limits in dynamical systems. The action will be able to gather mathematicians from different communities, give an impulse to existing lines of research and identify new long-term directions. Combined with the experience of the supervisor, the excellent training and the rich environment provided by the host, it will enhance the researcher towards an outstanding career in academia.

Keywords: kinetic theory,mesoscopic modelling,hydrodynamic limits,asymptotic preserving schemes,fast reaction,cross diffusion,population dynamics,skt system
High efficiency bifacial thin film chalcogenide solar cells (Hi-BITS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Portugal,France,Germany,Sweden,Poland,Switzerland,Luxembourg,Spain,Austria
Call: Novel Thin Film (TF) technologies targeting high efficiencies (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 4962618.54
EU funding (EUR): 4962618.54
Participants: 16
Project status: SIGNED

CIGS solar cells currently reach 23% efficiency with a metallic back contact and a >2µm thick absorber layer as well as excellent stability. Hi-BITS partners will introduce a disruptive device structure that allows a high degree of bifaciality and photon recycling. The efficiency will be improved beyond 25% by the innovative high quality CIGS absorbers and passivation at the back contact, which allows to remove compositional gradients and reduce absorber thickness. Hi-BITS will explore four different applications, that all use these features, including bi-faciality, flexible and reflective, semi-transparency and suitability for tandems. While the bi-faciality will harvest stray light reflected from the ground, and thereby increase the yearly yield, the reflective and flexible will enable photon recycling for light-weight modules. The necessary back reflector is easily integrated into the bifacial Hi-BITS cells. To close the gap in efficiency between large area modules and record cells, Hi-BITS will improve monolithic integration to increase the productive area of the module, and the semi-conductor quality by fast-feed-back methods fit for industrial processes. The applications foreseen as results from Hi-BITS respond to market demands and are particularly well suited for building or vehicle integration or agri-photovoltaics. Modules for these new applications will be out-door tested in three different European climates demonstrating higher energy yield and stability. Life cycle analysis and costing, taking aspects of circularity into account, will underline the superior sustainability of these new modules. Hi-BITS includes 5 European PV manufacturers, will improve a technology that does not depend on imports of ingots or wafers, reinforcing the European PV value chain. The results will boost thin-film manufacturing by higher efficiency, lower raw material consumption, shorter and well-controlled processes, better module technologies and novel applications.

Keywords: bifacial reduced absorber thickness reflective back contacts semi transparent solar cells cu in,ga se2 cigs