Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Missions: Engagement and Education for Tomorrow (MEET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 310081.74
EU funding (EUR): 284313.88
Participants: 9
Project status: SIGNED

MEET - Missions: Engagement and Education for Tomorrow - is the proposed “European Researchers Night” event and “Researcher at School” programme in Milano and Lombardy (Italy), for the 2024 and 2025 editions of the Night, and for the school years 2024/25 and (partly) 2025/26. Firmly rooted on a mission-oriented approach and bringing together top R&I and institutional players in Milano area, MEET has the challenging goal to reduce the gap between research and citizens, increasing their sense of trust in science and fostering a participatory approach in which everyone feels involved and benefits from the opportunities offered by scientific citizenship, in an inclusive way. The project combines a captivating science festival format for the Nights, targeting the public at large, with a two-years structured programme devoted specifically to the schools. During the Nights, science-based entertainment initiatives, interactive exhibitions, talks and participated moments, such as real-life workshops and science matches, will involve citizens in a journey to discover that R&I could and should be acted and enjoyed by everybody. At school, MEET brings public engagement initiatives and innovative education approaches, with researchers first-hand experimenting citizen science with pupils, engaging them preferably but not exclusively on the themes of the EU Missions. The acquisition and recognition by the research community of the role of citizen science as a research methodology will become a lever for an institutional change, supported by MEET. Overall, MEET will permanently work to stimulate proactive scientific citizenship to engage society and schools, through different tools and methods, in reflecting on grand societal challenges and on how science could shape culture and future habits, finally discovering how much impact could be produced by science in people's daily lives.

Keywords: citizen science,participatory approach,public engagement,education,missions,sustainability,inclusion,responsibility
Circadian rhythm: from preclinical to post-diagnosis dementia (RHYTHM IN DEMENTIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 1999982.5
EU funding (EUR): 1999982.5
Participants: 2
Project status: SIGNED

Circadian rhythm (CR) regulates body functions over the 24-hour day/night period; sleep/wake cycle is its most visible manifestation. CR disruptions have long been observed in patients with dementia and emerging evidence points to their presence in the preclinical period of dementia. This suggests that certain aspects of CR could be useful in identification of high-risk individuals and could serve as potential targets for interventions to delay dementia onset and progression. This requires an in-depth understanding of the role of CR in dementia pathogenesis. As population ageing increases dementia burden, it is critical to find strategies to identify patients at risk of dementia with precision, prevent, and slow its progression. Building on recent advances in accelerometery (to assess CR features comprehensively) and dementia biomarkers (deep-phenotyping of dementia pathogenesis), RHYTHM IN DEMENTIA will make a decisive step-change in knowledge by determining CR features involved in dementia processes along the course of the disease. The aims are: 1) identify core CR features that shape 10-year risk of dementia in a community-dwelling cohort of 4000 older adults; 2) uncover specific CR disruptions that characterise major dementia subtypes and stages of Alzheimer’s disease (determined by biomarkers) in a new cohort of 1500 patients recruited from two memory clinics in Paris; and 3) ascertain how CR affects dementia prognosis in the patient cohort by examining cognitive and functional decline, hospitalisation, institutionalisation, and mortality. This project will yield new insight into the nature of the association between CR and dementia progression. These findings will ultimately inform the potential for a cost-effective and easy to use tool to assess CR features to facilitate both identification of patients at risk of dementia and tailored secondary prevention interventions that address CR disruptions in dementia patients and slow progression of dementia.

Keywords: circadian rhythm,dementia,alzheimer s disease,accelerometer
Integrated Decision Support Tool for Reliable and Affordable Application of Manage Aquifer Recharge with Alternative Water Resources in River Basin and Drought Management Plans (MARCLAIMED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Spain,Poland,France,Austria,Portugal,Netherlands,Belgium
Call: Improve the reliability and effectiveness of alternative water resources supply systems and technologies (HORIZON-CL6-2023-CLIMATE-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 3731820.01
EU funding (EUR): 3209652.75
Participants: 14
Project status: SIGNED

MARCLAIMED will be a breakthrough addressing in an efficient, sustainable, and trustworthy way the water scarcity and water stress mitigation. MARCLAIMED will support decision makers to integrate Managed Aquifer Recharge (MAR) with Alternative Water Resources (AWR) in River Basin and Drought Management Plans supporting the adaptation and resilience of structural supply systems in the context of climate change. The main outcome will be the MARCLAIMED Integrated Decision Support Tool (IDST) that will provide solutions to tackle existing and emerging threats and support decision making and adaptation policies. MARCLAIMED IDST will ensure I) high level operational performance through 3 AI-based tools to: i) monitor and control AWR quality, ii) forecast the water resources availability and iii) provide health, environmental and performance risk indicators; II) economic sustainability under uncertainty providing: i) a municipal scale water scarcity indicator, ii) water security economic value of MAR with AWR and iii) a cost recovery-based system; and III) social acceptance, strengthen the engagement of national and EU policy makers in collaboration with a Community of Practice and the definition of EU MAR-lines, as rules and guidelines, to promote policy recommendations and boost regulatory framework. MARCLAIMED results will be implemented and validated in 3 demo sites in southern (PT, ES) and western Europe (NL) chosen by their wide range of settings in terms of climatic conditions, alternative water sources, MAR scheme or MAR potential, as well as political and socio-cultural context. In addition, to cover a wide spectrum of economic sectors and activities, an industrial feasibility study (in the mining sector) will be carried out in central (PL) and eastern Europe RIS countries.

Keywords: managed aquifer recharge,alternative water resources,water quality,resilience,decision support tool,artificial intelligence,economic sustainability,social acceptance,regulatory framework
Circular REDesign for a Resource-efficient, Innovative, and Transformative Built Environment (CRedIBlE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Lithuania,Greece,Spain,Italy,Cyprus,Romania,France,Netherlands,Switzerland
Call: Design for adaptability, re-use and deconstruction of buildings, in line with the principles of circular economy (Built4People Partnership) (HORIZON-CL5-2024-D4-02, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 3950037.5
EU funding (EUR): 3950037.5
Participants: 18
Project status: SIGNED

The Circular REDesign for a Resource-efficient, Innovative, and Transformative Built Environment (CRedIBlE) project aims to enable the design, adaptability, reuse, and deconstruction of buildings through a fully interoperable digital ecosystem. By integrating AI-driven decision-support tools, Digital Product Passports (DPPs), modular building components, and pre-dictive analytics, CRedIBlE provides a systematic framework for circular construction, material traceability, and lifecycle optimization. At its core, the CRedIBlE digital ecosystem will connect Building Information Modeling (BIM), Life Cycle Assessment (LCA), Digital Twin technologies, and AI-powered analytics, allowing stakeholders to make data-driven decisions on material reuse and circular renovation strategies. CRedIBlE will deliver: ▪ AI-powered Decision Support System (DSS) for material reuse prediction, modular construction, and renovation planning. ▪ Digital Product Passport (DPP) framework, ensuring traceability, embodied carbon tracking, and compliance with circular economy regulations. ▪ BIM-LCA integration tools, allowing real-time sustainability assessment of building components. ▪ A Digital Twin-based monitoring system, optimizing predictive analytics for adaptability and deconstruction. ▪ Modular and disassemblable building components, promoting low-carbon and circular construction methodologies. ▪ A Marketplace for secondary materials and components (HVAC, PV, solar collectors), facilitating material exchanges, refurbishment, upcycling and industry-wide circularity adoption. Additionally, CRedIBlE will introduce: ▪A policy framework for integrating Digital Product Passports into EU regulations. ▪AI-driven material flow simulations, optimizing deconstruction and material reuse scenarios. ▪Training programs and knowledge-sharing platforms, equipping industry professionals and policymakers with circular skills. ▪ Standardized modular construction guidelines, aligned with existing EU regulations

Keywords: circular economy digital ecosystem digital product passport reused building material buildings adaptability
REMOTE MICROSCOPY, NANOSCOPY AND PICOSCOPY BY HYPERSPECTRAL LIDAR (HyperSense)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2597500.0
EU funding (EUR): 2597500.0
Participants: 1
Project status: SIGNED

HyperSense will spearhead hyperspectral lidars expanded to exotic spectral regions outside the imaginable by lidar community, and demonstrate stand-off biosensing beyond what can be resolved by existing methods by employing plasma and supercontinuum light sources. Leveraging my patented hyperspectral Scheimpflug lidar concept, adding an uncontested number of spectral bands, spatio-temporal resolution and sensitivity, We will reveal aspects of our biosphere inaccessible by existing lidars. Active remote sensing of our biosphere uncovers details that cannot be resolved in space and time by sunlight, e.g. protein absorbance shielded by the ozone layer, life in dark ocean depths, narrow oxygen lines in a breath or nocturnal movements of disease vectors. Lidar constitute an efficient measurement technique where the same light transilluminates a volume until it interacts with the sample and simultaneously reports range and backscatter quantitatively, whereas hyperspectral lidar also provide microscopic absorption pathlengths, nano-features on biological surfaces, and deformations of electron shells on the picometer scale. HyperSense will explode multiple boundaries of current lidar, demonstrate and revolutionize biomonitoring, by my inexpensive, robust, compact and portable Scheimpflug method. HyperSense comprise 4 novel hyperspectral lidars with short, long, narrow and broad spectral coverage, applied to 8 biological challenges, showcasing light-biology interactions on the micro, nano and picoscopic level: A) DUV lidar (220-440 nm) Biomolecules specificity for classification of pollen and lichen B) Aquatic lidar (400-800 nm) Profile plankton biodiversity using both oscillatory and spectral properties C) Hires NIR lidar (760-762 nm) Resolving O2 and temperature in breath to understand host seeking and hill-topping in insects D) SWIR lidar (900-2500 nm) Quantify the surface nanostructures, internal tissue microstructure and molecular composition of vegetation and aerofauna

Keywords: laser remote sensing,lidar,hyperspectral,environmental monitoring,biophotonics,tissue spectroscopy,supercontinuum,plasma sources,instrumentation,infrared,ultraviolet
Actin-based motility of intracellular human pathogens (ACTIN in ACTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 2312500.0
EU funding (EUR): 2312500.0
Participants: 1
Project status: SIGNED

Actin and its associated regulatory proteins are fundamental components of the cytoskeleton, playing a central role in nearly every process in eukaryotes. Remarkably, the intracellular pathogens Shigella and Listeria have evolved specialized proteins, known as effectors, to hijack this crucial system of the host. These effectors induce actin polymerization on the bacterial surface, allowing the pathogens to propel themselves within and between host cells through a process called actin-based motility (ABM). Despite the critical role of ABM in bacterial infections, the mechanism by which ABM effectors interact with and activate host cell proteins is not understood at the atomic level. In addition, the regulation mechanisms of ABM and the host cell response to the cytoskeletal manipulation remain unclear. I therefore propose to elucidate the mechanisms of actin regulation during intoxication by ABM effectors. Using single-particle cryo-EM and cryo-electron tomography — techniques that have only become widely accessible in the past decade — I will determine the first high-resolution structures of ABM effectors and their complexes with actin-regulatory proteins. Building on my extensive expertise in studying actin and its associated proteins with these cutting-edge methods, I will develop a detailed mechanistic model of how ABM effectors orchestrate and regulate the host cytoskeleton, as well as how host cell proteins influence ABM within the cellular environment. Hypothesizing that cytoskeletal modulation by ABM effectors triggers cellular responses, I will employ a combination of proteomics and transcriptomics analyses to decipher how this manipulation of the actin cytoskeleton impacts host cell response pathways. This study will provide atomic-level insights into actin cytoskeleton regulation during bacterial infection, laying the groundwork for developing targeted therapies against diseases like shigellosis and listeriosis, which pose major medical challenges.

Keywords: actin cytoskeleton,bacterial toxins,cryo em,molecular pathogenesis
Integrated Multi-vector-borne diseases Platform to Assess how global Change impacts Transmission using Innovative systems modeling, Novel monitoring tools, and transmission blockinG micro-organisms (IMPACTING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,Kenya,Portugal,Mozambique,Cameroon
Call: New tools, technologies and approaches for vector control in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 6153640.63
EU funding (EUR): 6113862.5
Participants: 11
Project status: SIGNED

Determining how climate and global change are driving the geographical variation of vector-borne diseases (VBDs) transmission dynamics is essential to measure current and future risks and to effectively roll out innovative surveillance and vector control strategies aiming at reducing the burden for the most vulnerable populations, especially in Sub-Saharan Africa (SSA). IMPACTING aims to: 1) model the risk of VBDs spread under global change focusing on mosquitoes (malaria, dengue, chikungunya, yellow fever), tsetse (human African trypanosomiasis), blackflies (onchocerciasis) and ticks (Crimean-Congo haemorrhagic fever); 2) develop vector monitoring and pathogen diagnostic tools for improved surveillance; 3) develop robust pipelines to identify transmission blocking micro-organisms within vectors and define innovative VBD control strategies; 4) engage local rural and urban communities to co-develop solutions for VBD monitoring and control, bypassing current community level barriers; 5) develop a multi-VBD risk prediction dashboard to facilitate evidence-based policy making focused on innovative control strategies resilient to climate change. IMPACTING is built on a consortium of eight research institutes, three universities and one SME - based in Kenya, Cameroon, Mozambique, France and Portugal. It gathers expertise in social sciences, entomology, ecology, epidemiology, genomics, bioinformatics, modelling and software development, fostering an interdisciplinary approach. IMPACTING draws on extensive experience in other EU projects and strong fruitful collaborations to fill the gap in knowledge and innovation for VBDs and vector control in SSA and globally. IMPACTING aligns with the Africa CDC Strategic Plan 2023-27 and EU global health strategy. It focuses on improving health security through African leadership in research and innovation, combining digital and biological sciences, capacity building, and engagement with African communities and public health actors.

Keywords: systems dynamics,global change,cascading effects,species distribution,surveillance,vector traps,attractants,microbiome,symbionts,malaria,cchf,trypanosomiasis,arboviruses,onchocerciasis
Novel approaches for halogen-free and sustainable etching of Silicon and Glass (HaloFreeEtch)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Czechia,Belgium,Austria,Italy,Netherlands
Call: EIC Pathfinder Challenge: Responsible Electronics (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3997735.0
EU funding (EUR): 3997735.0
Participants: 7
Project status: SIGNED

Current industrial plasma etching processes are not sustainable because they make use of halogens. HaloFreeEtch will take a fundamental, interdisciplinary and systematic approach to find new halogen-free etching processes. HaloFreeEtch aims to identify new, halogen-free and sustainable etching processes for sustainable semiconductor manufacturing, applied to deep etching of silicon and silicon oxide. The novel etching processes we aim for shall be clean (in terms of harmful chemicals), efficient (in terms of processing speed and manufacturability) and precise (in terms of the desired shapes). HaloFreeEtch will provide a novel model- and data-based methodology for sustainability and life cycle analysis of plasma-etching to quantify the carbon-footprint of all novel etching processes. HaloFreeEtch combines lab-scale research on three innovative technological routes with computational screening of novel and promising etchants, a comprehensive multi-scale modeling approach to predict potential working points and a model-based life cycle and sustainability analysis. Hydrogen (H)-based, metal catalyst-assisted as well as approaches inspired by atomic layer etching (ALE) will be studied. State-of-the-art plasma etching machines will be modified and combined with innovative features and advanced analytics. Besides getting rid of halogens, we will address more dimensions of sustainability such as the high energy consumption of the established plasma etching processes. HaloFreeEtch will implement a novel, sustainability-driven process development scheme which might serve as a blueprint for sustainability-driven process development in electronics and many other industries. The project will focus on the semiconductor industry, where plasma etching is a standard industrial process used for many applications. Taking the lead in the development of innovative halogen-free processes will strengthen the long-term position of the EU in the global chips industry.

Keywords: halogen free,etching,plasma,drie,icp,ccp,magnetron,magnetized icp,magnetized ccp,merie,silicon,glass,semiconductor,mems,microfluidics,life cycle analysis,process modeling