Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Future Advanced system for an on-demand Insurance Reliable product based on driving behaviour analysis (FAIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Italy,Italy,Italy
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 2507878.75
EU funding (EUR): 1755515.13
Participants: 4
Project status: CLOSED

The world is shifting to a new business model, were customers have changed their purchasing path: they are happier subscribing to the outcomes they want, when they want, rather than purchasing a product with the burden of ownership. Consumers today have new expectations; they want to achieve outcomes, not ownership; customization, not generalization. The car insurance market is traditionally linked to the old bonus-malus model, a system that penalizes the ones who make accidents and rewards those who do not incur in them. In a consumer oriented world, insurance becomes a tool for the driver and not just a mandatory cost. What do you think about a relevant cost reduction (up to 40%) but also an added value according to driver behaviors? And what about a system connected with your necessity? A free coffee when you are tired? Gasoline discounts? A free coverage for your weekend because you are a good driver? FAIR meets such requirements, developing a cloud-based ecosystem to commercialize big data and machine learning based insurance, turning customers into subscribers. The coordinating partner in cooperation with an insurance broker and a multimedia company is launching an on-demand insurance service for connected cars. The new insurance policy is revolutionizing the traditional sector with a Pay-Per-Mile and Pay-how-you drive approach, introducing access to discount/cash back opportunities, setting-up and managing insurance packages via app and accessing new safety and reporting functionalities. The new model will be coupled with a service for car dealers and fleets that will bring advantages in terms of car health remote monitoring, knowledge of customers’ experience and advertising tailored service. The competitive advantages: superior risk selections and loss control; analytics to support digital underwriting process through a war room based on driving and crash data; better pricing and cost claims reduction and reporting functionalities to government facilities.

Keywords: car insurance,subscription economy,telemetry,connected cars,on demand services,car market
TURBOmachinery REtrofits enabling FLEXible back-up capacity for the transition of the European energy system (TURBO-REFLEX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Germany,Germany,Spain,Spain,Italy,Germany,Germany,Sweden,Switzerland,Poland,Poland,Poland,France,Czechia,Czechia,United Kingdom,United Kingdom
Call: Highly flexible and efficient fossil fuel power plants (H2020-LCE-2017-RES-CCS-RIA, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 8414830.0
EU funding (EUR): 7212095.0
Participants: 31
Project status: CLOSED

The energy sector accounts for two thirds of the global CO2 emissions and is therefore crucial to ensure future green growth and to achieve the global emission reduction targets. Substantial reduction of CO2 emissions can only be achieved by large scale deployment of renewable energy sources, including in particular the most abundant energy sources, wind and sun. Their intermittent nature however poses significant challenges for the energy system as peak demand from the system and peak production form those intermittent sources do not overlap. As there are no large scale storage solutions available yet, other backup capacities are needed. The installed fossil capacity is large enough to provide this back-up power. However, the plants were designed for baseload operation, which results in increased wear and costs through cyclic operation and unnecessarily high emissions in the start-up phase. Providing technology upgrades to retrofit the installed power plants to enable flexible operation without penalties on life, cost and emissions is an opportunity to quickly provide the necessary backup capacity to keep the energy system stable and resilient and at the same time enabling higher renewable shares. TURBO-REFLEX will follow this approach and has selected technologies for retrofitting critical parts of thermal power plants which have already seen experimental proof-of-concept and are expected to significantly contribute to flexible operation. The technologies will reduce the minimum load, increase the ramp rates and reduce the costs per cycle. This will be achieved by new compressor designs for off-design operability, technologies in the hot gas path, in combustor and turbine, and by new materials, models and sensors to monitor and ensure the mechanical integrity in flexible operation. An integrated assessment will provide not only the technological but also the economic benefits for plant operators, thus ensuring a swift implementation of TURBO-REFLEX technologies.

Keywords: retrofittable technology,flexible backup power generation,grid stability,robust turbomachinery design,ccgt,power plant optimisation,load ramping,analytics,condition based monitoring
How does a need turn to a want: using Drosophila melanogaster to identify how the gut-brain axis mediates protein appetite (Body2Mind)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-10-01
End date: 2024-04-27
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: SIGNED

The quality and quantity of consumed nutrients, including proteins, has a significant impact on health and lifespan across phyla. Essential amino acids (eAAs) are an extreme case, as many animals, including humans and Drosophila, cannot efficiently synthesize them, and thus relay solely on protein intake to obtain them. Thus, understanding the molecular changes mediating the organism´s response to such an imbalance is highly important. It is established, that animals respond to a single eAA deficiency behaviorally and metabolically. Evidently, the organism recognizes eAAs-imbalance and translates it into a specific foraging behavior and feeding decisions appropriate for compensating for such specific nutrient deficiency (i.e increased protein preference and feeding). How this is done however remains elusive. We hypothesize that this nutrient imbalance drives molecular changes that are "mirrored" in gene transcription in order to drive the response to eAA imbalance, in a tissue specific manner. In this project we will unravel molecular mechanisms involved in the metabolic and behavioral responses to eAAs imbalance , while focusing on protein appetite, in a comprehensive manner. To achieve this, we propose to employ a novel high-throughput RNA sequencing method to decipher tissue specific translational changes following eAAs deprivation. Using a bioinformatic approach, we will look into the processes underlying these transcriptional changes. Interestingly, preliminary data already reveals common biological pathways underlying the response to all eAA deficiencies the fly gut. We will genetic approaches to test the relevance of these pathways to protein feeding and to the physiological response to eAA deficiencies. We foresee this project to open an essential next step in nutritional- neuroscience research, with potential to further our knowledge about the link between stomach, gut and brain signals in driving nutrient homeostasis.

Keywords: drosophila feeding,gut brain axis,protein appetite,nutrition
Automatic Scalable VM Management for Data Centre Optimisation (FishDirector)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Estonia
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall vision of the FishDirector project is to bring to market our innovative software solution for real time live optimization of cloud data centres to enable optimum use of server resources and reduce overall energy use by at least 30%. To reduce the number of servers needed to deliver services and reduce overall energy consumption data centres have adopted virtualization, running VMs (virtual machines) on each server. VM workload is dynamic, varying in response to user demand. However, data centre operators do not currently have a comprehensive automated system for optimally placing VMs and allocating the optimal number of servers to meet the workload requirements. This results in sub-optimal hardware utilization (typically 18% whilst consuming 60% - 90% of their maximum system power), a larger number of servers than is necessary, higher energy consumption and a poorer end user experience due to lower response time and/or intermittent availability. FishDirector works with OpenStack to address this problem by providing a scalable software solution for automating VM placement in a highly dynamic environment and consolidating live VMs data centre-wide, ensuring continuous operation and load balancing. Unlike existing solutions, it allows data centre operators to automatically optimize resources for VM instances across multiple servers in a scalable manner and with no practical limit to the number of servers that can be managed. FishDirector has been successfully demonstrated in small server installations and is thus at TRL6. We seek funding for the Phase I Feasibility Study to explore the viability of moving FishDirector to TRL 9 through a Phase 2 project to demonstrate and validate FishDirector in a large data centre (> 100 servers). The expected outcome is the technical and economic validation of the FishDirector software solution with data and documentation ready for commercialization across European and US markets.

Keywords: data centre,optimisation,energy consumption,server,virtual machine,scalable,openstack
Envisioning a New Governance Architecture for a Global Europe (ENGAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Poland,Türkiye,Belgium,Finland,Belgium,Slovakia,France,Netherlands,United Kingdom
Call: The Common Foreign and Security Policy and the expanding scope of the EU's external engagement (H2020-SC6-GOVERNANCE-2020, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 2999973.75
EU funding (EUR): 2999973.75
Participants: 13
Project status: SIGNED

The ENGAGE (“Envisioning a New Governance Architecture for a Global Europe”) project will advance the goals that are aligned with the European Commission’s push to have a stronger and more united European voice in the world. ENGAGE will answer how the EU can effectively and sustainably harness all of its tools in a joined-up external action, with an eye to meeting key strategic challenges and becoming a stronger global actor. Our contribution to this ambitious quest will be anchored to a comprehensive and detailed analysis of all dimensions of EU external action, which will go even beyond the call’s requirements. ENGAGE brings together a consortium that provides first-class academic expertise of European and international scholars who cover the entire scope of the EU’s external action, involving many practitioners with vast experience in relevant governmental bodies. Our project will be based on 11 Work Packages (WPs). Two initial WPs will provide an analytical grip on the contextual hurdles, both international and domestic, that the EU faces in the implementation of its external policy. This will in turn inform the other core research WPs of ENGAGE, which are divided into two interconnected clusters. The first cluster will aim to revamp the governance architecture of CSDP, CFSP as a whole, and other dimensions of EU external action (including peripheral and sectoral diplomacies), while the second cluster will aim to improve the performance of the EU’s external action when engaging with strategic partners, its neighbourhood and conflict scenarios. The contextual WPs and the two clusters will converge in a strategic WP – the cornerstone of ENGAGE – that will produce a White Paper for Joined-up, Coherent, Sustainable, and Effective External Action. All of ENGAGE’s deliverables and recommendations will be targeted at policymakers across the EU, and seek to spark an inclusive and representative EU-wide conversation.

Keywords: coherence,international organizations,global strategy
Bootstrapping Time: Colliders, Shocks, Strings, and Black Holes (KAIROS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland,Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1455000.0
EU funding (EUR): 1306250.0
Participants: 2
Project status: SIGNED

Two pillars of modern physics are Quantum Field Theory (QFT) and General Relativity (GR). Together they describe a vast corpus of phenomena ranging from the smallest scales accessible with modern accelerators to the largest distances observed with modern telescopes. Establishing these frameworks is a triumph of 20th-century physics. Our understanding of both is not satisfactory. On the QFT side, we lack tools to analyze the strong coupling regime. On the GR side, we do not understand how to make it quantum. The insight of holography is that these two problems are deeply connected, in other words, QFT and Quantum Gravity (QG) are different realizations of the same underlying mathematical structure and physical principles. Providing us with this fundamental insight, holography does not tell us what the underlying structure is. The challenge for 21st-century physics is to understand it. The aim of the present proposal is to establish a research team at CERN that: a) will {\it develop new nonperturbative Lorentzian bootstrap methods} as a part of a larger quest of revealing the unifying mathematical structure and physical principles that underlie both QFT and QG; b) use these methods for state-of-the-art {\it computations of real-time physical observables} which are not accessible using conventional methods. This will lead to new insights into the fundamental properties of QFT, QG, and holography which relates the two. The principal novelty of the project is in its focus on the nonperturbative real-time dynamics, as opposed to Euclidean observables which are typically studied using the current bootstrap or other methods. Bootstrap takes fundamental principles of physics, such as causality, locality, and unitarity, and pushes their consequences to the extreme. Combined with insights from holography, bootstrap methods offer an unprecedented set of tools for diving into uncharted territories of QFT and QG.

Keywords: conformal bootstrap,s matrix,holography,quantum gravity
Novel senolytic drugs for the treatment of lung and kidney fibrosis (SENFIB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

SENFIB aims to deliver new drugs for the treatment of fibrotic diseases. Nearly one quarter of the global population will be over the age of 65 by 2050. Populations over 65 suffer from multiple degenerative diseases including tissue fibrosis, estimated to account for upwards of 45% of all-cause mortality. Animal models have demonstrated that senescent cells are causative in many fibrotic diseases including lung (i.e. idiopathic pulmonary fibrosis, IPF), and chronic kidney disease (CKD). Senescent cells have experienced damage or stress and have permanently exited the cell cycle, yet remain viable and long-lived, generating a persistent, sterile inflammation. Selective elimination of senescent cells in animal models of IPF, CKD, and aging demonstrated improved organ function and viability. Senolytics, molecules that induce preferential killing of senescent cells while leaving healthy cells intact, have emerged as a promising approach for tackling age-associated diseases; this was named one of the “10 Breakthrough Technologies” of 2020 by the MIT Technology Review. Thus far, few senolytics have been identified; their mode of action is often unknown, some present serious toxicities, and none has yet been demonstrated to have therapeutic activity in clinical trials. We propose to launch a drug discovery program based on a prioritized novel genetic target for senolysis, which we have already validated as senolytic using a tool compound in an in vivo model of IPF. We will deliver a lead series of molecules with IPR that meet all typical drug requirements plus in vivo Proof-of-Concept data in different mouse models of IPF and CKD. The ultimate goal of this project is to develop candidates for translation into clinical use to ameliorate fibrotic diseases via the selective elimination of senescent cells.

Keywords: senescence,fibrosis,senolytics,degenerative disease,aging
Innovative eco-friendly crosslinker for leather and textile finishing (Green-linker)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 1488412.5
EU funding (EUR): 1041888.75
Participants: 1
Project status: CLOSED

Green-Linker is a crosslinker, a type of chemical product used by tanneries in the leather sector and dyers in the textile sector as a finishing agent. The ranges of chemicals used today are often toxic and potentially harmful to the environment. Tanneries and textile dyers are looking for cost-effective and eco-friendly solutions that would allow them to comply with stringent regulations on harmful chemicals, and with the strong request by consumers of environmentally sustainable leather garments and accessories. The market for leather and textile chemicals is projected to grow steadily (4% CAGR) until 2024 following these market trends. Current crosslinkers in the market cover only partially client’s needs since they have limitations in terms of quality, toxicity and environmental sustainability. Italkem has developed, in a single product, an innovative crosslinker with superior characteristics. Green-Linker offers technical, environmental, and economic advantages over its competitors. Green-Linker results as the best performing in terms of highest temperature tolerance, fastest reaction time and longest pot-life, and colour fastness while its eco-friendliness level equals the best option in the market. Green-Linker meets the severe constraints imposed on the environment and toxicity of chemicals, being the ideal candidate to be recognized with Eco-Label as a sustainable and green product. In addition, its competitive price (37% saving respect the highest technical performance) is strongly supported by an improved storability, transport and logistic capacity. From Italkem we have been trading since 2002 serving global markets from Italy. We plan to introduce this novel product in the market after final validation with industrial end users and up-scaling production. This will allow us to grow our turnover from crosslinkers and create new jobs.

Keywords: crosslinker,finishing agent,tannery,leather,textile,reach,chemicals
Green and Resilient Europe: What role for nano-enabled industries? (EuroNanoForum 2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Belgium,Portugal,Portugal,Portugal
Call: Presidency event (conference) in Portugal: EuroNanoForum 2021 (H2020-IBA-LEIT-NMBP-Portugal-Presidency-2020, 2020)
Start date: 2020-11-04
End date: 2021-07-03
Duration (months): 8.0
Total project cost (EUR): 99813.02
EU funding (EUR): 99813.02
Participants: 4
Project status: CLOSED

Nanotechnology and Advanced Materials play a major role in our daily life as they guarantee the functioning, long term durability, safety, and environmental compatibility of many devices, machinery and services. Advanced materials can boost the transition to greener technologies, with improved characteristics and enhanced performance, contributing to a more sustainable future and contributing to the objectives set by the European Green Deal. Giving this central role of nanotechnology and advance materials and its relevance for a sustainable, social- and environmental-friendly growth, the EuroNanoForum 2021 will be addressing the role of nano-enabled industries in the drive towards a green and resilient Europe. Nanotechnology and advanced materials play a pivotal role in advancing technologies that can offer efficient solutions to societal challenges of our time and important issues that continue to haunt the global industrial supply chains. They exert a great impact on a large range of industrial sectors and are cornerstone to build a sustainable and green economy. Supporting this industrial transformation towards the EU prosperity requires reinvigorating the research and industrial ecosystem, establish new communities and involve all groups in society in identifying nano-enabled technological priorities. The EuroNanoForum 2021 conference will be addressing the role of nano-enabled industries in this transformation towards the EU prosperity. The event will bring together experts across different sectors to identify policy options and priorities, to share insight on technical, industrial and social challenges, their views and ideas about the role of nanotechnology and advanced materials. This will be achieved with the collective effort of several actors encompassing researchers, innovators, industries, regions, public authorities, investors and civil society, in the co-creation of innovative solutions.

Keywords: nanotechnology,advanced materials,european green deal,nextgenerationeu,horizon europe