Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Impact of Neutrino-Nucleus Interactions on DUNE's CP-Violation Measurement (ARNU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The question of why matter is able to exist in abundance in our Universe is one of the most exciting open questions in physics today. One possible source of a matter-antimatter asymmetry is an as yet undiscovered difference between neutrino and antineutrino oscillations (CP-violation). DUNE is a next generation long-baseline neutrino oscillation experiment that aims to discover CP-violation in neutrino oscillations for the first time. An intense accelerator (anti)neutrino beam from Fermilab will be directed at far detectors 1300 km away. In order to observe this difference, the experiment must contend with the fact that our planet and detectors are made of matter and not antimatter. Any differences between the way neutrinos and antineutrinos interact with atomic matter must therefore be well understood in order to disentangle these differences from CP-violation in the neutrino oscillations themselves. In this action I will work to reduce the systematic errors on DUNE's CP-violation measurement caused by uncertainties in our understanding of neutrino-nucleus interactions. The work will be centered around DUNE's currently operating prototype detectors. This work is essential to conduct now since DUNE will use argon as its neutrino interaction target nucleus, resulting in more complex nuclear effects than experienced by the current generation of long-baseline neutrino oscillation experiments, which use lighter nuclei. In particular I will simulate the effects of different nuclear models on the interaction probabilities for neutrinos and antineutrinos and apply new analysis techniques to better distinguish between different nuclear models, ultimately improving DUNE's sensitivity to CP-violation in neutrino oscillations.

Keywords: cp violation,liquid argon tpcs,neutrino nucleus interactions,convolutional neural networks,simulating particle interactions in matter,deep learning,neutrino interaction generators
Mucosal antibody and B cell responses during Tuberculosis (MART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-04-14
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), kills up to 1.5 million people every year. Despite sustained scientific attention, there is no effective vaccine, multidrug-resistant Mtb strains are on the rise, and impoverished people with little access to long, expensive treatments continue to bear the brunt of disease. A critical barrier to the development of an effective TB vaccine is our incomplete understanding of what constitutes a protective immune response. Accumulating evidence suggests a role for B cells and antibodies in preventing and alleviating TB. Existing studies show that some Mtb-specific antibodies found in blood may confer protection against infection. However, whether such protective antibodies exist at the site of infection and in what quantity remains unknown. The goal of this project is to characterise antibody responses in the lung mucosa of mycobacteria-infected mice and humans, and to assess their relationship to protection versus disease. First, I will identify the antigenic targets of antibodies isolated from lung and lymphoid organs of infected mice by proteomics. Then I will use tetramer-based enrichment and single cell RNA sequencing to investigate the dynamics, transcriptional regulation and B cell receptor repertoires of lung-resident, antigen-specific B cells – the source of lung mucosal antibodies. Finally, I will translate these findings from the mouse model to humans, using bronchoalveolar lavage fluid from a clinical study of TB patients with different grades of TB susceptibility. This approach will allow me to assess the existence of these mucosal antibodies in humans and to investigate their function and protective potential. Combining the mouse infection model with this unique TB patient cohort represents a unique opportunity to address the impact of humoral immunity in the lung mucosa, thus providing a sound basis for the development of mucosal airway vaccines against TB.

Keywords: tuberculosis,antibodies,b cells,mucosal immunity,vaccine targets
Volcanoes' Night III. - Researchers' Night of the Canary Islands (Volcanoes Night III)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 227225.0
EU funding (EUR): 153000.0
Participants: 2
Project status: CLOSED

People have been fascinated by volcanoes ever since the dawn of mankind and treated them with utmost respect. The rapid development of converging technological areas, such as informatics, material science or space research multiplied our knowledge of earth processes and created some highly specialised fields within volcanology. At the same time a dramatic gap has formed between the professionals and the public. As a result, in today’s world, the work of volcanologists is nearly as mythical as the work of volcanoes in ancient times. The objective of this project is therefore to address this issue and bridge the gap between science and the general public of different ages. Participating scientists will not only talk about their field of research, but will also share their experience on how students can approach science and research institutions, providing perfect scenario to attract young people to science careers. During Volcanoes Night participants will be provided to access research facilities, and a complementary scheme of workshops, science cafés, excursions, presentations and challenge games will be arranged all to fuel the public’s curiosity, interest and understanding of research activities. As a backdrop to the Night volcanoes will be used not only to explain the work of volcanologists but also to explain what science is about and what scientists and researchers do during their daily work.

Keywords: geosciences,geology,volcanology,environment,earth sciences,science communication,canary islands
Shot noise scanning probe microscopy: probing the dynamics at the atomic scale (SN-STM_FM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The dynamics of exotic systems such as high-temperature superconductors and heavy fermion materials is gaining ever increasing interest as it contains important clues to the mechanism driving the often unanticipated and technologically very relevant properties. Shot noise spectroscopy is a very powerful technique to study the dynamics of electronic correlations in such quantum electron systems, but to date has been limited to mesoscopic systems. We propose to set up, test and use an experimental probe that can perform shot noise measurements on the atomic scale, thereby gaining access to crucial information on the scale where all the action occurs: the atoms, the electrons, and – in combination with spin resolved tunneling spectroscopy – the spins. We will achieve this by developing a low temperature, high frequency compatible scanning tunneling microscope. This project will combine expertise on shot noise spectroscopy at CNRS in Paris and low temperature scanning tunneling spectroscopy expertise of the experienced researcher, and will bring important new insights into the time domain properties of correlated electron systems.

Keywords: scanning probe microscopy,shot noise,low temperature,high frequency
KAIRÓS - Key Account services and Innovation management support for TRivenetO SME’s (KAIROS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 371408.75
EU funding (EUR): 371408.75
Participants: 13
Project status: CLOSED

Following the previous projects KANT ( ID: 643327) and MAKEOVER ( ID: 674860) and KAIROS (1) (ID743797) KAIRÓS aims at improving the innovation capacity of SMEs in Triveneto area. In particular KAIRÓS: · will support an accurately selected group of SME’s of Triveneto macro region inclined to innovation, in order to design, create and maintain an Innovation Management System (IMS). Enterprises receiving KAIRÓS services will be selected taking into account their innovation potential.These companies will be provided with a specific service for enhancing the innovation management capacity (EIMC), in order to include a systematic innovation approach as an asset for growth and competitiveness; · will support beneficiaries of SME Instrument, FET Open and Fast Track to Innovation with a Key Account Management service focused on helping the companies to better exploit the opportunities offered by these EU-Programmes and reduce time to market; KAIRÓS activities and results will be exploited through Friend Europe-Enterprise Europe Network for animating local events and debates for rising the awareness of the local stakeholders about the European Standard for Innovation Management CEN/TS 16555-1. KAIRÓS will deliver up to 7/10-day service packages according to the invitation from EASME

Keywords: innovation,sme instrument,competitiveness,sme support,integrated support,growth,horizon2020
Topological superfluidity in ultracold gas of Dysprosium atoms (Topological superfluidity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

In the last decade experimental and theoretical studies in condensed matter demonstrated that materials with strong spin-orbit coupling can host a new state of matter for the electron gas - a topological insulator. More recently the concept of topological matter was generalized theoretically to superconducting systems with strong spin-orbit coupling. The topological character manifests itself in the presence of quantum states bound to edges or defects that exhibit exotic physical properties. In topological superconductors, edge states are described as Majorana fermions. These exotic particles - originally predicted in high-energy physics - are non-abelian anyons: their quantum statistics is neither bosonic nor fermionic. Observing Majorana fermions would be the first demonstration of such exotic particles. The field of ultracold atoms seems well suited for the realization of superfluid systems with strong spin-orbit coupling. As shown in recent experimental works, manipulating manipulating atomic internal states with lasers can mimick spin-orbit couplings of strong amplitude. We have constructed at College de france a new experimental setup producing ultracold Dysprosium atomic gases. This atomic species exhibits narrow electronic transitions that should allow one to create such a spin-orbit coupling without substantial heating, which is the main requisite for creating a superfluid state. Combining spin-orbit coupling and strong interactions should lead to the formation of a topological superfluid. We will investigate the structure of quasi-particle excitations of this superfluid, which should exhibit edge modes described as Majorana fermions.

Keywords: topological superfluidity,fermi gas,spin orbit coupling,majorana fermion,dysprosium
Characterization of the mechanism of inter-organ communication coordinating tissue growth and developmental timing (CoordinGrowthDev)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-06-20
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Over the recent years, research in developmental biology has stumbled upon the problem of how development ensures that organisms achieve appropriate body and organ size. The coordination of organ growth with the developmental program is essential for the emergence of adults with proper body size and proportions. These species-specific features condition many traits of adult life such as fitness and survival. Studies on fruit flies have allowed setting up the conceptual frame for this research. Our current understanding is that tissue growth and the developmental program are synchronized by feedback control mechanisms that block the transition to the next developmental period until all tissues have completed growth. Recent work in Drosophila has started unraveling the nature of the signals that couple tissue growth with developmental progression. A newly discovered Drosophila insulin-like peptide called Dilp8 is key in this coupling, raising the possibility that peptides with similar roles may exist in vertebrates. The current project aims at characterizing the molecular mechanisms by which Dilp8 coordinates development of the different body parts. First, I will conduct a biased genetic screen to identify the receptor for Dilp8. This will allow a better characterization of the biological functions of Dilp8. On one hand, I will unravel the target tissues of Dilp8 mediating regulation of steroid hormone and developmental transitions. On the other hand, I will investigate the role of Dilp8 signaling in coordinating growth among developing organs. The project will shed light on the mechanisms of inter-organ communication that ensure the coordination of growth between tissues and with the developmental timing. The expertise of the host laboratory, combined the conceptual frame and experimental approaches of the project, will allow me to gain new skills and scientific knowledge, and to develop a successful research career in the field of growth control.

Keywords: growth control,coordination,inter organ communication,developmental timing,dilp8,insulin,steroid hormone,drosophila
Regulation and Function of Endocrine-Specific Splicing Programs in Pancreas and their Role in Diabetes (ePANC-SPLICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Pancreatic beta cells are highly specialized cells that play a key role in maintaining glucose homeostasis by secreting insulin. Dysfunction or loss of beta cells results in diabetes, a worldwide growing epidemic. Extensive research has started to uncover the signals and transcriptional networks that control specification, differentiation and maturity of the different pancreatic cell lineages, and in particular of beta cells. However, posttranscriptional regulation during pancreas development has remained mostly unexplored. Alternative splicing (AS) is the main posttranscriptional mechanism that generates transcriptomic and proteomic diversity, playing essential roles in cell specification and functional specialization. My previous data suggest that beta cells activate neuron-related splicing programs involved in the regulation of insulin secretion. Moreover, pro-inflammatory cytokines (mediators of beta cell failure in type 1 diabetes) affect the splicing of signaling and pro-apoptotic genes that determine beta cell survival. However, the presence of beta- or endocrine-specific splicing programs and their role in diabetes remains to be clarified. In this project, we will investigate the regulation and function of endocrine-specific alternative exons. I will combine comparative transcriptomics, biochemical and functional studies, iPCS reprogramming and zebrafish knock-outs to: (i) comprehensively identify endocrine-AS exons, and study their regulation during beta cell differentiation and pancreas development; (ii) probe the phenotypic impact of endocrine-AS programs on beta cell differentiation and function; and (iii) Investigate the role of ENDO-AS exons in remodeling transcriptional and signaling networks involved in diabetes. We foresee that this project will provide new insights into beta cell pathophysiology and generate valuable knowledge for the development of splicing-modulating therapies and disease biomarkers.

Keywords: alternative splicing,microexons,rna binding proteins,pancreatic beta cells,diabetes,insulin secretion,pancreas development,endocrine cells
Impact of climate on mountain denudation (ICED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-10-01
End date: 2026-03-31
Duration (months): 78.0
Total project cost (EUR): 1431285.0
EU funding (EUR): 1431285.0
Participants: 1
Project status: SIGNED

Mountain ranges evolve in response to tectonic uplift, erosion and climatic change, but decoupling the feedbacks between these processes remains one of the most active debates in Earth Science. Resolving this debate is fundamental for successful projection of Earth’s surface response under a changing climate. The Impact of ClimatE on mountain Denudation remains highly contested because no technique is available to resolve changes in erosion rates over the timescale of glacial-interglacial cycles i.e. 10^3-6 years, a key time range for quantifying the role that silicate weathering and denudation plays in modulating global climatic change. ICED will resolve this debate through establishing time-series of rock erosion over 10^3-6 years, allowing erosion rate changes to be related to specific climatic changes, and specific processes, for the first time. These data will show whether tectonics or climatic feedbacks on surface processes are dominant in determining rates of surface denudation, providing insights into the influence of the lithosphere on global climatic change throughout the Quaternary period (ice age). The objective of ICED will be achieved through the development and application of recently established thermochronometers based on the luminescence and electron spin resonance of quartz and feldspar minerals. Thermochronometers measure the rate of rock cooling, from which rates of rock exhumation and thus erosion rates can be calculated. Unlike existing methods, the new techniques developed within ICED are capable of resolving changes in erosion over timescales of between 10^3-6 years. Combining these new methods with cosmogenic nuclide data, using numerical models developed within ICED, will allow the generation of high-resolution time-series of erosion. The strategic application of these new techniques to the western European Alps will allow the Impact of ClimatE on mountain Denudation rates to be resolved for the first time.

Keywords: geochronology,quaternary,electron spin resonance dating,luminescence dating,geomorphology
Revolutionary projector platform for virtual and augmented reality eyewear (REALITY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 3195000.0
EU funding (EUR): 2236500.0
Participants: 1
Project status: CLOSED

Augmented reality (AR) and virtual reality (VR) technologies are finally starting to emerge from the lab into applications for everyday life. Researchers agree that the industry is only beginning its global triumph and will grow significantly in the next years – global AR/VR revenues are forecasted to hit €144 billion by 2020. The potential of AR/VR market cannot, however, be fully realised unless eyewear with an appearance of regular glasses become available. So far, it has been impossible to build proper AR/VR eyewear because of the large size and complexity of the required electronics. The biggest unsolved issue in the industry has been the imaging component which would generate excellent image quality and be small enough to enable production of AR/VR eyewear that consumers are willing to wear continuously. Finnish SME Brighterwave has created a revolutionary laser light source that is 97% smaller than its closest competitor, enabling a mass-producible ultra-compact projector engine providing the best image quality in AR/VR eyewear. We have successfully completed SME Instrument Phase 1 project NOVLASE that confirmed the technological, practical and economic feasibility of our projector engine. The REALITY project will focus on miniaturisation and productisation of the existing technology. The specific objectives of the project are: • Optimise and fabricate a laser light source and a projector engine for AR/VR eyewear; • Demonstrate the projector engine in AR and VR applications in cooperation with customers (large consumer electronics manufacturers); • Promote the technology to potential new clients to ensure commercial success. Successful completion of the project will result in the world’s smallest projector engine that enables building the first consumer-friendly AR/VR eyewear, and make Brighterwave the preferred laser projector provider in the AR/VR market by 2020.

Keywords: augmented and virtual reality eyewear,projector engine,laser light source