Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social Mobility and Inequality across Italy and Europe: 1300-1800 (SMITE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: CLOSED

The goal of SMITE is to improve our knowledge of long-term trends in social mobility, from the decades immediately preceding the Black Death of 1347-49 up until the eve of Industrialization. The objective is not only to measure mobility, but also to understand its consequences for the economy and society at large. Very few data about preindustrial social mobility are available today, especially for southern Europe. SMITE will collect an extensive database about social mobility, measured in different ways including: economic mobility across wealth classes and occupational mobility. Archival research will be concentrated on Italy where excellent sources exist, but the Italian case will be placed in the wider European context. The few existing databases from all over the continent will be collected for comparison and direct research will be done on some regions of Europe beyond Italy, especially in France, Spain and the Low Countries. SMITE will reconstruct social mobility trends both in growing and in declining areas of Europe. The connection between social mobility and economic growth will be assessed. SMITE will also analyse in detail the connection between long-term changes in social mobility and in economic inequality, which is a novel and potentially very important research avenue. It will receive from an earlier ERC project (EINITE) the largest existing database on preindustrial inequality. It will study whether the growth in economic inequality, which seems to have characterized both northern and southern Europe during the early modern period, went hand in hand with an increase in upward social mobility or whether there were differences across the continent. In fact, upward social mobility might have slowed down in southern Europe from ca. 1600 (as some literature suggests) but not in the North, thus determining in the South a particularly unfavourable combination of high inequality and a closed society which might have contributed to the North-South divergence

Keywords: social mobility,economic inequality,preindustrial europe
Sustainable. Clean. Uncompromising. The Internal Combustion Engine Becomes Green (H2Engine)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 2191253.76
EU funding (EUR): 1533877.63
Participants: 1
Project status: CLOSED

The combustion engine is the most widespread energy conversion machine and the most important drive system for vehicles, construction machinery, agricultural machinery and even ships. It is not replaceable as a form of drive. Especially for transport vehicles that have to carry heavy weights. As a result of that fact, the combustion of fossil fuels in engines generates 23% of the global CO2. With the EIC project, we want to make the combustion engine environmentally friendly and bring the KEYOU-inside- technology (TRL6) to the market. KEYOU-inside- are components that can be integrated into new or existing combustion engines and enables the engine to run on hydrogen. The product defines a leap in terms of current capabilities and qualities and addresses a gigantic market. Our starting market alone, the bus and truck industry, has a volume of €350 bn. In principle, our customers are all OEMs and end customers in the conversion business. We are open to manufacturers and therefore extremely scalable. In the future, even large generators, ship engines etc. can be made hydrogen capable with our system. Hydrogen combustion engines offer many advantages: the same availability and service life as Euro 6 vehicles, higher customer value than alternative drive concepts (payload, number of passengers, range), low susceptibility to maintenance and the existence of an service infrastructure. Although various manufacturers have recognised the potential of an H2engine, they have never been able to resolve the conflict between zero emissions, efficiency and economy. KEYOU can meet this demand: An emission-free vehicle that, in comparison to the Euro 6 vehicle, can be operated with high performance, customer benefit and at the same time with unchanged total costs. The technology is the key factor of KEYOU and leads to a significant growth in sales and employees (Target: 162.9 Mio by 2024) and to a zero reduction of CO2 emissions in mobility. KEYOU - emission-free technology.

Keywords: hydrogen combustion engine,zero emission technology,emission free vehicle
Scrap dealing in the digital age: a transparent and efficient platform for price and supply chain management (Schrott24)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Schrott24 is a digital platform, available as a web-based platform and mobile application that helps scrap metal sellers to maximise their financial returns and scrap metal recyclers to operate at full capacity. Schrott24 brings the old-fashioned, regional and offline industry of scrap dealing online where dealers can trade anywhere and anytime for the best price. Our technology brings transparency to this marketplace that has historically been untrustworthy and difficult to navigate. Sellers simply select the scrap they want to trade, choose their method of transport, and get paid accordingly. This is a radical shift from the time consuming options that are currently available. Best prices are guaranteed for customers as we take care of the negotiation with the scrap recycler. Our scrap metal prices are updated daily to align with the current market standard. The SME Instrument project aligns itself perfectly with the innovation strategy and mission of Schrott24: to commercialise a novel, easy-to use, transparent and trustworthy platform for trading scrap metal that guarantees best price for sellers and maximum returns for recyclers and smelters. While it has enormous economic and environmental potential, funding is required to achieve our objectives in order to reach full commercialisation. Funding to date has allowed us to develop our technology into a working prototype that is operational in Germany and Austria. The SME Instrument would enable us to complete the development of our technology and fully commercialise throughout Europe and subsequently worldwide. By leveraging our extensive network in the scrap industry, in tandem with our developed software, we have a clear advantage over existing solutions.

Keywords: minerals,scrap metals,optmisation,supply chain management,recycle
Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy (qBioNano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-21
End date: 2019-08-20
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

As a Marie Skłodowska-Curie Fellow in “qBioNano: Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy”, I will combine three emerging fields—layer-by-layer (LbL) assembly of nanoparticles (NPs), microfluidics, and live cell Raman spectroscopy (RS)—to enable 3D imaging and quantification of how NPs and cells interact under physiological conditions. This will allow, for the first time, non-invasive, non-destructive, label-free, spatiotemporally resolved study of a range of biomolecules (e.g., lipids and proteins) and biostructures (e.g., nuclei and mitochondria) at the same time as LbL assembled NPs to answer long-standing questions on particle-induced changes in cellular states and processes. The NPs will be produced through LbL assembly of alkyne-containing polymers (having Raman spectra clearly visible in biological environments), and—using microfluidic devices (where cells can be introduced and maintained in physiologically relevant environments)—I will study how these NPs affect both healthy and diseased cells and tissues (e.g., at cell-cell interfaces and using spheroids). This project will provide: (i) the first detailed view into the biology underlying cellular responses to LbL assembled NPs under physiological conditions, and (ii) a new platform offering insight into key cellular processes and responses governing how cells and tissues interact with, and respond to, engineered NPs. By combining my expertise in developing NPs, microfluidic systems and investigating bio-nano interactions, with the supervision of Prof. Molly Stevens at Imperial College London (ICL), who runs a world-class interdisciplinary biomaterials group with extensive experience in RS, materials science, and cell and tissue biology, this project is uniquely situated to address these urgent—but challenging—topics and deliver the highest quality results.

Keywords: bio nano interactions,cell particle interactions,nanoparticles,materials science,live cell raman spectroscopy,microfluidics,layer by layer assembly
PAPRAT (Predictive Algorithm for Pre-Rheumatoid Arthritis Treatment). The new and most efficient multiple biomarkers-based system for an early selection of RA treatment intensity (PAPRAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Rheumatoid arthritis (RA) affects 1% of world population (17.6 M) and it is a relevant economic burden (€45 Bn spent yearly in Europe). It is a degenerative disease that affects bone health, cause joints’ deformity, impact other organs and cause disability. An early and personalized treatment can greatly improve its outcome, achieve remission and reduce pain, thus an accurate prognosis is critical for its efficient management. However, this is difficult for the lack of good prognosis factors (currently rheumatoid factor-RF or anti-citrullinated protein antibodies-ACPA), which at present are very few, poorly accurate and leave 40% of patients unclassified (suffering health complications due to an unnecessary aggressive treatment or from deterioration due to delays in proper treatment). Making Genetics is a Spanish start-up focused in personalized medicine through genomic approaches. We have designed and developed a prognostics test for RA based on a blood test and the use of our new PAPRAT algorithm, with 82.4% accuracy. PAPRAT is a multiple biomarker-based system capable of classifying pre-rheumatoid arthritis patients, discerning which will need a more aggressive treatment. It combines unique genomic markers (genetic and epigenetic), as well as clinical and demographical variables, to calculate a predictive index and classify patients’ RA severity as HIGH (needing early administration of a combined therapy with biological DMARDs) or LOW and MEDIUM (non-biological DMARDs are enough). It is at a TRL6 and now we aim to optimize it, further validate it, develop a software platform and prepare its market launch. RA is expected to grow by drivers such as an ageing population or the continued uptake of biosimilars, and we have currently a total addressable market of 17.6 M patients globally and of around 3M in Europe. We will offer a complete prognosis service, including the blood testing, as well as the licensing of our software platform once it is finished.

Keywords: rheumatoid arthritis,biomarkers,epigenetics,prognosis,dmards,prognosis software,personalized medicine
Understanding and predicting PATHOgen COMmunities (PATHOCOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,France,France,United States
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-07-01
End date: 2027-06-30
Duration (months): 72.0
Total project cost (EUR): 9945744.0
EU funding (EUR): 9945744.0
Participants: 5
Project status: SIGNED

Infectious disease is often the major selective agent in nature, and we cannot understand how populations evolve without understanding their pathogenic microbes. Beyond host immunity, an important factor determining the ability of pathogens to invade and proliferate in a host is the resident microbiota, but we are only beginning to glimpse its multifarious impacts. We know even less about interactions among pathogenic microbes themselves. Any effort to explain how pathogen communities, or pathobiota, develop within a host requires knowledge about the extent to which pathogens engage in competition, commensalism and cooperation, both with other pathogens and the rest of the microbiota. To date, studies of plant-pathogen interactions in the lab and descriptive work in the field have focused on pairwise interactions between one plant host and one pathogen, leaving a large gap in our understanding of how different types of interactions between microbes, and especially pathogens, determine the outcome of host-pathogen interactions in the real world. In PATHOCOM, we will implement a program that integrates large-scale field observations of microbes in the plant Arabidopsis thaliana with ultra-high-throughput experimental tests of host-dependent interactions among microbes, allowing experiment-informed modeling of pathogenic microbe-microbe interactions. These models, which will be improved through an iterative process of data collection with synthetic communities, will illuminate how interactions, from pairwise to higher-order, shape microbial community composition and structure. In the final step, the resulting models will be tested against and refined with field data. Together, these efforts will transform the study of plant pathogens by applying deep analyses of microbial interactions in an ecological context to explain patterns in nature. Ultimately, PATHOCOM will play an essential role in refashioning plant-pathogen-microbiome studies into a predictive science.

Keywords: arabidopsis thaliana,ecological genomics,pathogen pathogen interactions,host microbiota interactions,ecology community structure,community modeling
Gamete and embryo cryobanking for the preservation of threatened endemic fish (CRYO-FISH)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Populations of fish species endemic to the Iberian Peninsula have been declining since the mid-20th century due to several factors such as habitat loss, water quality deterioration or presence of alien fish species. Furthermore, with the tendency for global warming, the typical summer droughts in Iberia are expected to become more intense and extended in time, so this fact could pose an additional extinction risk factor for the native fish. In this regard, from the 26 native species of the Portuguese freshwater fish, around 70% are already under threat according to the IUCN. Cryo-Fish will progress on basic knowledge of the reproductive biology of endemic freshwater ichthyofauna, assessing for the first-time gamete quality throughout the breeding season. New techniques for gamete assay and protocols for cryopreservation will the purpose of creating a genetic resource bank for biodiversity preservation. From the point of view of basic research, Cryo-Gamete is going to reveal unknown aspects of breeding cycle of the most endangered cyprinids, providing data that will help ex situ conservation captivity programs. The data that will be systematically collected and analysed will create knowledge on the right timing to collect gametes and how to manage them to assure artificial propagation of species in captivity. On the other hand, this proposal wishes to lay the groundwork for making a genetic resource bank of the most endangered fish species at national level. In this regard, new gamete cryopreservation protocols will be designed for the project goal species, being possible to have a wild-phenotypic backup of each population. Finally, Cryo-Fish is going to approach a novel technique located on the frontier of scientific knowledge: fish embryo cryopreservation. This technique will be addressed based on a laser gold nanotechnology, and it will be applied for the first time in freshwater endangered species within the topic of preserving biodiversity.

Keywords: gamete quality,cryobanking,cryopresevation,ex situ conservation
TAPEMELT: Recyclable thermal activated tape system (TAPEMELT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain,Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Packaging tapes are the most widely used pressure sensitive adhesive tapes with global production in excess of 10 billion sq. meters per year . Their primary application is corrugated carton closure. However, existing solutions for this application present 3 key constrains: 1.RECYBLABILITY – WASTE MANAGEMENT: One of the major issues for the label printing industry is the waste the process leaves behind, particularly the much maligned release liner. With consumption of self-adhesive label materials in Europe in 2010 totalling 5.3 billion square metres, translating into some 360,000 tonnes of paper liner waste emerging from end users. 2.TAMPER-EVIDENT: Cartons sealed with PSA or many of the water-activated adhesives are not secure and are not easily accessed without revealing any signs of tampering. 3.TAPE SEALING PROBLEM IN REFRIGERATED PACKAGES: Both PSAs and Water-Activated lack adherence depending on temperatures. They typically reduce or lose their tack at low temperatures and reduce their shear holding ability at high temperatures; special adhesives are made to function at high or low temperatures. We have developed a product that provides a proper answer to this 3 needs: TAPEMELT: an adhesive system thermal activated that cover the existing constrains in the carton packing industry. It is 1) Low-cost; 2) Fast to apply 3) Strong: the integrity and safety of the goods are not compromised 3) Allows custom printing; 4) Theft-protection – Tamper evident 5) it is made of paper: 100% recyclable, repulpable and biodegradable.

Keywords: blue ocean,high growth,gazelle,business innovation,disruptive innovation
Integrating Research Infrastructure for European expertise on Inclusive Growth from data to policy (InGRID-2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Slovakia,Belgium,Greece,Sweden,Belgium,Poland,Hungary,Belgium,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-05-01
End date: 2021-10-31
Duration (months): 54.0
Total project cost (EUR): 9345420.5
EU funding (EUR): 9345420.5
Participants: 19
Project status: CLOSED

Referring to the increasingly challenging EU2020-ambitions of Inclusive Growth , the objectives of the InGRID-2 project are to advance the integration and innovation of distributed social sciences research infrastructures (RI) on ‘povety, living conditions and social policies’ as well as ‘working conditions, vulnerability and labour policies’. InGRID-2 will extend transnational on-site and virtual access, organize mutual learning and discussions of innovations, and improve data services and facilities of comparative research. The focus areas are a) integrated and harmonized data, (b) links between policy and practice, and (c) indicator-building tools. Lead users are social scientist involved in comparative research to provide new evidence for European policy innovations. Key science actors and their stakeholders are coupled in the consortium to provide expert services to users of comparative research infrastructures by investing in collaborative efforts to better integrate micro-data, identify new ways of collecting data, establish and improve harmonized classification tools, extend available policy databases, optimize statistical quality, and set-up microsimulation environments and indicator-building tools as important means of valorization. Helping scientists to enhance their expertise from data to policy is the advanced mission of InGRID-2. A research portal will be the gateway to this IRI. Networking activities will provide initiation (summer schools), in-depth discussions (expert workshops), and help to promote necessary innovations for sustainable inclusive growth. Extending the RI to all EU countries is an important mission on the agenda for InGRID-2. Based on surveyed users’ needs, joint research activities are conducted in the focus areas and concentrate on extending data integrations, exploring new data linkage and sources, innovating microsimulation tools, improving comparative policy data, and investigating new high-quality indicators.

Keywords: research infrastructure,poverty,living conditions,working,conditions,vulnerability,social policy,employment policy,inclusive growth,integration