Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting Smart Regional Innovation Ecosystems (BOOST)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Romania,Bulgaria,Estonia,Denmark,Spain
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 499968.0
EU funding (EUR): 499968.0
Participants: 6
Project status: CLOSED

Our vision is to “co-create Europe'' through a 21st century mindset, methodology, skills and tools, closing the innovation gap between “innovation leaders” and “moderate/modest innovators”. We rely on inclusion and active participation of actors, institutions and places that collaborate to maximize the value of innovation to society and ensure equitable diffusion of its benefits. BOOST project proposes a systemic approach, both inclusive and collaborative, to strengthen innovation ecosystems in Europe. The main aim of BOOST project is to increase the scope and efficiency of interregional collaboration among project partners and their regional innovation ecosystems, in the following thematic areas: Industry 4.0, Cleantech and Green Transition, Health & Well-being, and ICT & Digital Transformation, by designing a structural (multi-dimensional) Interregional Collaboration Framework (ICF), develop tools and mechanisms that enable and support the operationalization and scale up of the ICF among Smart Regions, and contribute to the transition towards Green and Digital Regional development models and policies in Europe. BOOST proposes a two-phase implementation process: (1) first the co-design and co-development of project’s core concepts: Vision, mission, ICF and Unique Selling Proposition, and initiating the BOOST community and collaboration Corridor; and (2) second to set up and mature the ICF among Smart Regions by developing a joint 5-year Innovation Action Plan, aligned with regional/national/EU innovation policies and synchronized with innovation funding mechanisms across partner regions and EU. The consortium brings together 4 partners (TIT, NWRDA, BBF and CLDI) from 3 modest and moderate innovator countries Bulgaria, Romania, and Spain, and 2 partners (VK and TSP) from 2 lead innovator countries Denmark and Estonia, enhancing exchange of innovation and boost best practices at the level of public and private stakeholders.

Keywords: regional innovation ecosystems,interregional collaboration framework,co design,co development,smart specializations,industry 4 0,cleantech,health and well being,ict and digitalization
Listening to the Queer Diaspora: A Cartography of the Psychosocial Care Provided to Queer Refugees (LISTENINGS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The care of refugees is a pressing issue in light of the geopolitical context in both the UK and EU. Refugees, particularly those facing intersecting vulnerabilities related to gender and sexuality, are frequently subjected to various forms of violence, as shown in both academic and societal discourses. The project LINSTENINGS proposes an innovative interdisciplinary study in the field of psychosocial care for queer refugees, integrating art, psychoanalysis, and clinical writing. The aim is to enhance psychosocial listening practices through writing workshops with clinicians working with this population across public and private mental health services in the UK. In an interdisciplinary manner, the project seeks to map and analyze artworks created by queer refugees in the UK, creating a comprehensive portfolio and public archive. This archive will serve as interpretive material for symbolic analysis and a foundational resource for future writing workshops. Moreover, the project will develop an innovative methodology of "psychosocial cartography" through these workshops, promoting collective reflection on care practices while moving beyond the individualistic focus of traditional psychoanalytic methods. The research further aims to advance the study of gender and sexuality in psychoanalysis from a decolonial and intersectional perspective, focusing on the queer diaspora. With three primary research objectives and six work packages, this proposal merges artistic practices with clinical methodologies to establish a network of professionals and create an alternative counter-archive of care. Ethical and legal considerations regarding using images and sensitive data will be addressed, ensuring confidentiality and proper credit to the artists and participants. This project's anticipated impact is theoretical and practical, broadening psychosocial approaches and developing new ways of caring for marginalized populations through the integration of art and clinical care.

Keywords: psychosocial psychoanalysis refugee care queer
Proton, electron And Neutron sources for non-destructive Testing ANd Investigations and treatment of materials (PANTANI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The main goal of the PANTANI project is to complete the design of an innovative laser-driven radiation source suitable for applications in materials science, inspection and treatment, as well as the development of some of its key components. Accelerators are exploited to produce particles and radiation needed for applications of high industrial and social relevance, like analysis of objects of historical, artistic and environmental interest, sterilisation of medical instrumentation, inspection of cargos and goods. Large-scale diffusion of these applications is prevented by the intrinsic limits of the available particle sources in terms of costs, dimensions and flexibility. In this frame, laser-driven particle sources represent an appealing solution to overcome these limitations. They are potentially cheaper and more compact compared to conventional accelerators. Moreover, they can provide several kinds of particles to perform multiple applications with the same source. These novel sources are subject to active research, but no industrial applications are currently available. Starting from the results obtained with the ERC CoG ENSURE and ERC PoC INTER projects, PANTANI aims to address key aspects, never considered before, to develop a laser-driven particle source dedicated for the applications: 1) the development of an application-oriented design of the entire acceleration system; 2) the identification of commercial laser solutions compatible with the source requirements; 3) the production and test of a prototype radiation detector; 4) radiation protection assessment of the designed system, also from the legislative point of view. All these results achieved by exploiting the expertise from both academy (Politecnico di Milano, Host Institution) and industry (the RayLAB and SourceLAB partners) will allow bridging the gap between fundamental research and the development of a realistic, multi-purpose laser-driven particle source suitable for applications.
Leveraging Sacrifice to Strengthen Relationships: The Importance of Couples’ Sacrifice Communication (SAYcrifice)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

Romantic relationships are essential for health and well-being. In fact, a poor-quality relationship is a more powerful predictor of increased mortality than smoking. Yet, divorce rates have more than doubled among the 27 EU countries in the last five decades. One reason why relationships are hard to maintain is because couples face difficulties navigating challenging interactions, such as when one partner sacrifices their preferences for the other. Sacrifice occurs regularly and can fuel resentment, thus putting relationships at risk. Yet, sacrifice also may convey that the sacrificer cares about the recipient, and thus has the potential to strengthen relationships. Given the profound impact of relationships on health and well-being, it is crucial to identify how couples can reduce the costs and reap the benefits of sacrifice to maintain satisfying relationships. Existing research examining the impact of sacrifice has focused on individuals’ internal feelings and motivations. Prior work, however, overlooks how individuals express their feelings and thoughts about the sacrifice, and neglects the dyadic interaction between the sacrificer and recipient. SAYcrifice aims to address these critical gaps by examining (1) how both partners communicate about sacrifice and (2) how sacrifice communication styles shape personal and relationship outcomes. SAYcrifice will integrate across different fields (relationship science, communication, social cognition) and combine state-of-the-art methods (dyadic, observational, diary, and longitudinal methods; implicit and explicit measures) to provide the first comprehensive investigation of couples’ sacrifice communication in close relationships. The findings will reveal effective ways for couples to communicate about sacrifice, which can be used to develop interventions to promote satisfying relationships. Transforming sacrifice into a catalyst for building happier relationships will in turn improve societal health and well-being.

Keywords: close relationships,sacrifice,communication,emotions,implicit attitudes,relationship satisfaction,personal well being,dyadic,observational,diary,longitudinal
An Insulin-Gold Nanoplatform as Enhanced Antibody-Drug Conjugate Cancer Therapy (Golden-ADC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Antibody-drug conjugates (ADCs) have emerged as promising therapies by combining the precision targeting abilities of antibodies with the potency of chemotherapy drugs, to directly attack cancer cells and minimize damage to healthy tissue. However, approved ADCs show low efficacies in treating solid tumours, due to inherent challenges. These include design challenges, which limit the drug-antibody ratio and the ability to integrate multiple drug types, and delivery challenges, in which pharmacokinetics and tumor barriers limit ADC accumulation and distribution within tumours. In the framework of the ERC-CoG project, we are developing gold nanoparticles (GNPs) that harness insulin for delivery of large therapeutics, including antibodies, across biological barriers. As part of this research, we have recently revealed that these insulin-GNPs can be further developed as an ADC nanoplatform. This Golden-ADC nanoplatform enables simple conjugation of large payloads of multiple antibodies and drug types, shows efficacy in cancer cell models, and enhances in vivo tumor accumulation, together with deep penetration and wide distribution throughout the tumour. In this PoC proposal, we will test our Golden-ADC nanoplatform for effective and safe treatment of triple negative breast cancer, due to the potential high benefits that our nanoplatform can provide for this hard-to-treat cancer, which has a long-standing paucity of effective therapies. Within GOLDEN ADC, we aim to acheive significant progress in the technology development process, by proof of concept demonstration of efficacy and safety of the Golden-ADC conjugated with multiple drugs in in-vivo triple negative breast cancer models. We also intend to achieve business readiness, via consolidating the IP strategy, undertaking a comprehensive market analysis, end-user engagement and developing the business strategy.
RECYCLE, REPURPOSE AND REUSE END-OF-LIFE WIND BLADE COMPOSITES – A COUPLED PRE- AND CO-PROCESSING DEMONSTRATION PLANT (Blades2Build)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Denmark,Spain,France,Greece,Netherlands,Germany,Türkiye,Norway
Call: Demonstration of innovative materials, supply cycles, recycling technologies to increase the overall circularity of wind energy technology and to reduce the primary use of critical raw materials (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 15490034.0
EU funding (EUR): 12362239.68
Participants: 14
Project status: SIGNED

By 2030, renewable Energy Sources (RES), and its infrastructures, are expected to increase 40% in Europe. Parts of RES strategies are onshore and offshore wind energy. The investment into new RES infrastructure implies an update of the current wind turbines, resulting in waste of the composite materials that constitute blades. To turn RES into the most promising and economically viable sources of renewable energy, we need to provide clean renewable energy without any emissions during operation. The blades, among the most important components in the wind turbines, made with composite, are currently regarded as unrecyclable. It is estimated that by 2050 the end-of-life (EOL) blades waste will generate more than 2 Mt annually, and cumulative blade waste in 2050 will lie between 21.4 Mt and 69.4 Mt, worldwide. EOL options for decommissioning wind turbine blades should be explored with the aim of providing environmentally favorable guidelines for managing wind turbine blade waste, and the possibility for material recovery and recycling is crucial if circular economy is the goal in the wind power sector. One possibility to avoid the accumulation of EOL blades in the environment is to convert the composite blades into new environmentally friendly building materials such as green cement. This option would demand some processing of the composite waste. Another option could be the reuse of the blades directly without much processing, e.g. . as new blades or as other products. Furthermore, the composite waste from blades could be combined with similar waste from other industrial sectors to enlarge the potential of a composite wind blade recycling process. Therefore, the general scope of the proposed project is to evaluate and demonstrate in large scale the possibility of recycling or resource recovery from blades and similar waste materials in a large consortium with some of Europe's key players in areas of importance for the project.

Keywords: recycling of windblades
Colouring the Dark in Fluorescence Light (CoDaFlight)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,Greece,Norway,Germany,France
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2999300.0
EU funding (EUR): 2999300.0
Participants: 6
Project status: SIGNED

Abstract The radical vision of CoDaFlight (Colouring the Dark in Fluorescence light) is the development of a next-generation imaging platform capable of revealing in real-time new and more accurate information related to a patient’s body and its diseases through an innovative time-domain fluorescence imaging (tdFLI) technology. Real-time imaging of fluorescence lifetime, deep into the patient, permits the unlocking of rich information, where today’s medical imaging systems remain in the dark. This novel, breakthrough technology is expected to find in first instance broad applicability during medical surgery, where it will influence intraoperative decision-making on a per patient basis. The consortium encompasses unique, complementary and multidisciplinary expertise, by bringing electronic and biomedical engineers, physicists, chemists, medical scientists and medical doctors together. In a multidisciplinary, holistic approach they allow both parallel and integrated research progression, on semiconductor image sensors, mathematical algorithms, fluorescent dyes, and biological proof of concepts under medical guidance. CoDaFlight will kickstart a new biomedical research field, the development of new solutions towards unmet clinical needs and addresses the growing need for safe diagnostic tools that can interrogate molecular and/or physiological parameters in real-time for immediate feedback during medical interventions or for continuous health monitoring. The objectives of CoDaFlight are to develop the technological foundations that are needed to enable real-time in vivo tdFLI in medical practice and to integrate these foundations into a complete working imaging system. CoDaFight will demonstrate and disseminate the capabilities and potentials of this novel technology through real in vivo proof-of-concepts with the goal to facilitate technology acceptance by end-users and uptake in new markets and applications.

Keywords: time domain fluorescence imaging real time fluorescence guided surgery fluorescent dyes semiconductor image sensors mathematical algorithms biological proof of concept
Thermally-Activated Delayed Fluorescence Nanoparticle Assemblies for Photodynamic Therapy (TADF-PDT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Photodynamic Therapy (PDT) is a non-invasive cancer treatment that uses light-activated, photosensitising dyes to generate highly reactive oxygen species (ROS) within a localised biological environment, leading to the destruction of cancer cells, while sparing surrounding healthy tissue. The PDT process comprises two stages: administration of a dye, followed by irradiation with light. Since ROS is only generated at the light-activated sites, tissue destruction is highly localised and side effects are significantly reduced. The potential for PDT is clear. However, for all this potential, widespread adoption has stagnated: only three dyes have been approved for cancer treatment globally, while the dye most commonly studied in clinical trials - Photofrin - is a statistical mixture of oligomeric porphyrins. Dye design for many years has focussed on porphyrins derived from Photofrin, and more recently phosphorescent ruthenium(II) polypyridyl complexes. However, in this proposal, a new design strategy is proposed: thermally-activated delayed fluorescence (TADF) dyes are the targets of interest. These are all-organic compounds that have small singlet-triplet energy gaps, which causes them to undergo rapid intersystem crossing and reverse intersystem crossing between the singlet and triplet states. By accessing the triplet state, they can readily generate singlet oxygen, which is one form of ROS, marking their potential for PDT. These compounds have been widely used organic device applications, but their uses in biological applications such as imaging and particularly PDT are much less. This proposal addresses this gap, using novel, cationic, near-IR emitting, TADF dyes. Their delivery to cells will be achieved using biocompatible, Extracellular Vesicles (EVs), which have been shown to be improved PDT delivery agents over other methods.

Keywords: chemistry,luminescence,nanomaterials,therapeutics
IFR RPAS Integration into EuropeaN Airspace (IRINA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Belgium,Spain,France,Czechia,Sweden
Call: Industrial Research & Validation for Master Plan Phase C Air-ground Integration and Autonomy (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 8631551.95
EU funding (EUR): 4979600.01
Participants: 12
Project status: SIGNED

The project aims to continue the research work done in SESAR 2020 PJ 13 ERICA. It will finalize the effort for the ATM infrastructure and services and DAA regarding IFR RPAS integration in Airspace Class A to C. Also it will in an additional working package newly address the ATM infrastructure and services and DAA regarding IFR RPAS accommodation in Airspace Class D to G. Both Work Packages aim to support the full integration of RPAS into European Airspace and to address the transition between ATM and UTM airspaces.

Keywords: rpas,integration,airspace a c,airspace d g,daa,accommodation