Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CARBON-NEUTRAL PRODUCTION AND DIRECT FUEL-CELL DEPLOYMENT OF ISOPROPANOL AS ENERGY CARRIER (IsoPROPEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Germany,France,Italy,Netherlands,Austria,Norway,Croatia
Call: Development of next generation synthetic renewable fuel technologies (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-11-01
End date: 2029-04-30
Duration (months): 42.0
Total project cost (EUR): 3995636.25
EU funding (EUR): 3995636.25
Participants: 9
Project status: SIGNED

The use of condensed, synthetic energy carriers offers a prominent solution to decarbonizing heavy-duty transport, such as waterborne mobility. Fuel cells offer superior efficiency and emissions reduction over internal combustion engines for onboard energy retrieval. Hydrogen is considered the major contender energy carrier for fuel cell propulsion, but high compression costs and costly infrastructure for safe storage and bunkering in compressed or liquefied forms hinder widespread adoption. Methanol emerged as an alternative, enabling onboard hydrogen generation via reformers integrated with hydrogen fuel cells. However, its use releases significant amounts of CO2. IsoPROPEL aims to revolutionize this paradigm by pioneering the synthesis of isopropyl alcohol (IPA) as a renewable e-fuel of non-biological origin. Leveraging recent breakthroughs by the partners in electrified chemical-looping and tandem catalysis, an innovative process to selectively produce IPA from CO2 and renewable hydrogen will be validated at TRL4. Additionally, IsoPROPEL will advance the direct isopropanol fuel cell (DIFC) to TRL4 after developing fuel cell components with enhanced tolerance to this cell’s unconventional working medium. This emerging fuel cell technology enables direct energy recovery from liquid IPA via selective electro-dehydrogenation to acetone (ACE), eliminating CO2 emissions onboard and the need for alcohol reformers. It also enables seamless cycling between ACE (discharged) and IPA (charged) energy carrier forms via mild hydrogenation “recharging,” without pressurized or liquefied hydrogen throughout fuel synthesis, use, and recycling. Inland waterway transport serves as a test case. IsoPROPEL will optimize e-fuel production, DIFC integration with ship powertrains, and double-liquid fuel logistics. Techno-economic and life-cycle analyses in EU inland shipping corridors will assess the feasibility and sustainability of this renewable energy carrier for DIFC-powered vessels

Keywords: renewable fuels of non biological origin rfnbo rechargeable liquid energy carrier direct alcohol fuel cells zero co2 emissions inland waterways shipping
Enhanced cybersecurity for networked medical devices through optimisation of guidelines, standards, risk management and security by design (CYMEDSEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Greece,Italy,Austria,Switzerland,Portugal,Malta
Call: Enhancing cybersecurity of connected medical devices (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 6146725.0
EU funding (EUR): 6146725.0
Participants: 12
Project status: SIGNED

For the EU health industry to be competitive and to sustainably deliver internationally leading care quality, it is important that EU regulation, guidelines and standards enable effective and interoperable digital health innovation and promote a vibrant entrepreneurial EU sector. Safety and competitiveness are not mutually exclusive. To deliver on them requires a pace and intensity of technological innovation that is matched by intensive regulatory innovation. Smarter, adaptive, dynamic, and evidence-based regulatory approaches are needed, based on real world experience in representative use scenarios. CYMEDSEC has been designed with an optimum consortium of regulatory, cybersecurity, technology, evaluation, and clinical EU experts to address exactly this challenge. It provides close feedback loops between new technological paradigms and recommendation of regulatory approaches, fostering regulatory science fresh thinking. It will deliver novel security-by-design solutions for the oversight of ‘Internet of Medical Things’ (IoMT) devices, including connected in vitro diagnostics. IoMT ‘fleet’ cybersecurity oversight systems will be developed. Use cases explored include remote patient monitoring and critical care scenarios, for which the project will develop novel and highly secure gateway middleware. Our technological and methodological advancement will go hand-in-hand with detailed review of regulations and guidelines, the formal creation of a new IoMT cybersecurity standard, and evidence collection from representative case studies. These objectives are holistically interlinked, with learnings form each work area feeding into development and proposals in other areas. Key to this is the in-project development of a cybersecurity benefit-risk toolbox, which will further develop the state of the art, using qualitative and quantitively approaches, and will make these available as easily usable and findable Open-Source resources for manufactures and regulatory bodies.

Keywords: internet of medical things,in vitro diagnostic medical devices,benefit risk analysis,risk assessment,security by design,edge computing,remote patient monitoring,evidence based regulation
Memories and wellbeing in post-industrial communities. (MemoWb)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

MemoWb will address how current uses and different levels of community engagement with industrial heritage contributes to build practices of memory making that in turn impact on communities’ well-being in contexts of deindustrialisation. Through Community-Based Action Research (CBAR), qualitative analysis, and comparison of case studies in Portugal, Spain, and the UK, MemoWb will bring post-industrial communities’ perspectives to the centre of international debates about well-being, heritage and conservation that have taken place on academic and public policy levels. MemoWb will be conducted at the Institute for Social Movements (ISB) of Ruhr University Bochum (RUB, Germany) under the supervision of Professor Stefan Berger, a well-known specialist on the comparative history of deindustrialisation, industrial heritage, and memory. MemoWb will provide me research-based education on CBAR to address underdeveloped themes in industrial heritage studies, such as well-being, and will make post-industrial communities more visible and active in processes of heritage making. Moreover, it will contribute to the international project Deindustrialisation and the Politics of Our Time (DéPOT) to examine communities’ connections with industrial heritage and memory as experiences of deindustrialisation as well as responses to it.

Keywords: industrial heritage memory connections between heritage and wellbeing post industrial communities collaborative learning from communities
Integrative profiling and engineering of clonal cancer cell behaviours: from the tissue level down to the molecular scale (SpaceClones)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Clonal evolution in tumours, the process by which cancer cells expand, diversify and are selected, is a major determinant of tumour growth and response to therapy. How the co-existence of diverse cancer cell clones shape tumour development is a fundamental question that remains open, in part because of limitations on existing experimental platforms and analytical frameworks. Our expertise inferring multicellular behaviours within tissue microenvironments, together with recent advances in imaging, assay automation, and cell engineering, timely place us in an excellent position to profile and engineer clonal interactions within tumours from the tissue level down to the molecular scale, which enables targeting this important question with unprecedented throughput and spatial resolution. In SpaceClones, we aim to: (1) characterize clonal interactions in genetically engineered tumours at sub-100 nm resolution, (2) characterize clonal signatures under metabolically defined environmental conditions, and (3) examine the cell state of engineered clonal spatial patterns. To overcome a variety of challenges to understanding molecular and cellular mechanisms of clonal behaviours in tumours, I have designed a ground-breaking approach that combines highly-multiplexed imaging, in vitro and in vivo tumour models, cell engineering, super-resolution microscopy, combinatorial low-volume liquid handling, and algorithms for deconstruction of spatial patterns. Altogether, SpaceClones will exemplify how to imply causality on the emergence of clonal spatial patterns in tumours, having far-reaching implications for the study of any other multicellular system. Ultimately, a deeper understanding of clonal evolution will contribute in the design of more effective cancer therapies and tools to predict clinical outcomes.
Linking Intestinal Bacteria and Host Metabolism to Tackle Type 2 Diabetes with Novel Food (DiBaN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Italy,Portugal
Call: EIC Pathfinder Challenge: Precision Nutrition (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3999222.5
EU funding (EUR): 3999222.5
Participants: 6
Project status: SIGNED

Poor nutritional regimes are main drivers of metabolic diseases and intestinal dysbiosis. Type 2 diabetes (T2D) prevalence is expected to reach 7% of the global population by 2023, and to curb its rise is an urgent public health need. Intestinal dysbiosis is a determinant factor in the progression of insulin resistance to T2D, shifting host metabolism though undefined mechanisms whose understanding would be crucial to allow personalized interventions. Advances have been limited by microbiome complexity and inter-individual variance. DiBaN binds together the necessary combination of expertise to address this question, based on the concept that the initial driver of the nutritional effects is the metabolic shift that takes place in the intestinal bacteria which is transduced to the host. In this context, technological breakthrough tools for novel food development, that ensure the promotion of a healthy microbiome-host metabolic interface, are an urgent need to prevent dysbiosis and T2D. DiBaN will overcome current limitations in nutrient-testing by developing advanced ex-vivo platforms that fully recapitulate the in vivo setting of dysbiosis and insulin resistance, that will be validated with in vivo omic data. To warrantee the health promoting effects of novel foods we will test a new concept in the emerging field of insect food technology, that an adequate insect’s metabolic-intestinal health ensures the healthy properties of its derived products. The validation of this idea will also serve to identify biomarkers for the monitorization of the insect’s health status. A. domesticus will be the testing model of choice, due to its excellent nutritional profile, that will be boosted by complementing the insect’s diet with microalgae bioactive-rich extracts. All these data will be integrated for the design of a pilot artificial intelligence (AI)-based application for the prediction of personalized responses to nutritional interventions.

Keywords: insulin resistance,type 2 diabetes,metabolism,microbiome glycome,microalgae,insect,novel foods,organoids,organ on a chip,artificial intelligence
Novel Opaque Scintillator Technology for Nuclear Industry Imaging based on Anti-Matter Detection (AntiMatter-OTech)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Spain,United Kingdom,Germany
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 5722533.53
EU funding (EUR): 5722533.53
Participants: 6
Project status: SUSPENDED

We propose to deliver a novel technology for the nuclear industry to open the possibility of direct monitoring of nuclear reactions inside nuclear power plant cores. The new technology centres on a radically-new and totally counter-intuitive approach to radiation detection that has arisen from neutrino physics research. As of today, direct and rapid in-situ measurement of nuclear reactor fission activity is not possible. Our technology is expected to make this possible by using the copious neutrinos that stream out of nuclear reactors. Achieving this leap relies on the paradigm shifting nature of our approach. Detection of radiation makes extensive use of light emitting materials known as scintillators. These are nearly always transparent, to allow the light to be seen and measured. Our radically-new approach is to use an opaque scintillator, coupled with a lattice of optical fibres to extract the light. This technique naturally provides high-resolution imaging of anti-matter annihilation plus many other types of radiation (e.g. betas, gammas, neutrons), improving the signal to noise ratio of anti-neutrino detection by a factor >10x. Consequently, our technology would be able to tolerate the high background environment close to a reactor. The civil nuclear industry will benefit in a range of ways from safety and societal reassurance to operational efficiencies with a direct economic return. Our technology will also be able to provide remote monitoring and information on any nuclear processes that emit neutrinos, opening many potential new markets. Examples include spent nuclear fuel containers, fuel pools and waste disposal sites as well as nuclear warheads and fusion reactors such as ITER. Our inter-disciplinary consortium pulls together experts from mechanical and electronics engineering, nuclear and particle physics, chemistry and computing with our major industrial partner in the civil nuclear energy industry to make this radical new technology a reality.

Keywords: neutrinos detection nuclear industry reactor liquido
Illuminating radial genome organization in the nucleus (RADIALIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Italy,Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999655.0
EU funding (EUR): 1999655.0
Participants: 2
Project status: SIGNED

In exciting preliminary experiments leveraging our GPSeq method we discovered that the genome of mammalian cells in interphase folds into a steep radial gradient of guanine and cytosine (GC) density, which seems to persist at the level of individual mitotic chromosomes. However, we still lack a fundamental understanding of how this higher-order 3D genome architecture is established and what its functional implications are. Here, I go beyond the state-of-the-art and propose that the observed steep radial GC-gradient is a universal design principle of the radial arrangement of the genome in the nucleus—which I call the radiality principle—that provides a biophysical framework for spatially orchestrating key nuclear processes, beyond gene expression regulation. To test this hypothesis, in this project I pursue five Objectives: (1) First, we develop a novel approach (GP-C) for high-resolution single-cell 3D genome reconstructions to study whether the radial GC-gradient is indeed a universal property of nuclei across different species and cell types. (2) Next, we apply GP-C together with RNA-seq to monitor genome radiality and concurrent gene expression changes as cells undergo karyotype rewiring or significant epigenetic perturbations. (3) In parallel, we develop innovative approaches to probe the internal structure of mitotic chromosomes and model how genome radiality is reorganized as cells traverse mitosis. (4) We then expand our preliminary finding of large-scale DNA-RNA contact hubs that seem to shape cell-type specific radiality landscapes by opposing the radial GC-gradient. (5) Finally, we pioneer methods for profiling nuclear proteins radially and apply them to test the bold hypothesis that the radiality principle provides a blueprint for organizing numerous nuclear processes. This project aims at conclusively addressing long-standing questions in the field of 3D genome biology and proposes novel mechanisms of nuclear function regulation.

Keywords: 3d genome organization chromosomes mitosis dna rna contacts transcription factors fluorescence in situ hybridization high throughput sequencing
Hydrogen for Robust Off-road Application Modules (H2ROAM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Italy,United Kingdom,Belgium,Czechia,Germany,Austria,Netherlands
Call: Configurable Fuel Cell Powertrain for Non-Road Mobile Machinery (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 6683820.08
EU funding (EUR): 4999844.79
Participants: 11
Project status: SIGNED

H2ROAM (Hydrogen for Robust Off-road Application Modules) aims to advance and demonstrate adaptable hydrogen-powered powertrain systems at TRL6, designed to meet diverse fuel cell power demands. The project focuses on two primary configurations: a baseline (110kW) and a multi-configuration (200kW), with varying levels of hybridization to address the operational needs of non-road mobile machinery (NRMM) in agricultural and port activities. Building upon insights from past EU-funded initiatives like H2Ports and H2Mac, H2ROAM emphasizes the promotion and field validation of hydrogen-powered electric NRMM, showcasing their configurability, reliability, environmental sustainability, and economic feasibility. Through rigorous field demonstrations, H2ROAM will evaluate modular powertrain building blocks in dynamic and extreme operational conditions, including exposure to extreme temperatures, high humidity and corrosive environments, heavy vibrations and shocks, dust and debris, water and moisture, high mechanical loads, and continuous high-demand operations. The project also incorporates a comprehensive lifecycle and techno-economic assessment to ensure cost-effectiveness and long-term viability. Collaboration with stakeholders, who have actively endorsed H2ROAM from its conceptual stage, ensures alignment with market trends, regulatory standards, and practical industry needs. These include critical inputs on refueling risk assessments, dust impact on hydrogen infrastructure, and strategies for long-term adoption of fuel cell technology in NRMM. By addressing both technical challenges and market adoption barriers, H2ROAM contributes to the integration of hydrogen technology into industrial ecosystems, accelerating the transition to zero-emission machinery and fostering a cleaner, more sustainable future.

Keywords: hydrogen,fuel cells,nrmm,trl6,modular powertrain,agriculture,ports,harsh environments,hybridization,energy management,emissions,lifecycle,tco,refueling,sustainability,market uptake
Algorithms of information transfer between zebrafish individuals: from perceptual decisions to collective behavior (INTERZEB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Rapid information exchange between individuals is key to coordinated behavior. In a traffic lane, a well-timed brake can signal the presence of an obstacle to the drivers behind, avoiding a vehicle pileup. In a crowd of people, individuals can infer the position of an obscured exit from the movement of their neighbors. How do individual behavioral patterns enable efficient information transfer in a group? Animal biodiversity displays a vast amount of remarkable collective phenomena that can provide us insight into this question, such as the behavior of fish schools, manifesting almost instantaneous information transfer between individuals. The INTERZEB project will use zebrafish as a model system to experimentally establish the behavioral algorithms that enable individuals to transmit information within a group. By employing immersive virtual reality techniques for freely-swimming fish, the project will pursue two objectives: 1) Extracting the functions that enable information transfer from individuals in the front (leaders) to those in the back (followers) arranged in long transmission chains. 2) Establishing how information transfer in the above settings is modulated by feedback sent by followers to leaders. The resulting algorithms will be implemented in agent-based models and tested in collective simulations as well as in hybrid interactions between multiple fish and algorithm-controlled virtual “avatars”. The achievement of the project’s objectives will provide a substantial contribution to linking individual decision-making and collective animal behavior, will foster interdisciplinary exchange, and will offer potential inspiration for biomimetic technologies. The project will also strongly contribute to the Researcher’s professional growth by granting interdisciplinary training, leadership, and mastering of cutting-edge methodologies for the study of behavior.

Keywords: collective behavior,perceptual decision making