Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoengineered magnetoresponsive diagnosis and personalized treatment of pediatric inflammatory bowel disease (MAGNETO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Inflammatory bowel disease (IBD) is an incurable, inflammatory condition of the gastrointestinal tract (GIT) that affects millions of patients worldwide and places an enormous economic burden on society. Most alarmingly, children account for one quarter of all IBD cases with steadily increasing incidence. Current clinical practices for IBD diagnosis and therapy are demanding and ineffective in terms of treatment outcome, patient compliance and cost and by far not optimized for children. Our aim is to establish a theranostic platform for diagnosis and personalized treatment of pediatric IBD by an interdisciplinary approach bridging discovery of disease biomarkers, nanomaterial and drug delivery system engineering to manufacture of personalized dosage forms. We will capitalize on scalable and reproducible flame engineering to tailor the properties of superparamagnetic iron oxide nanoparticles (SPION) and achieve functionalities beyond their current use in the clinic. This multifunctional material will serve as contrast agent in magnetic resonance imaging, tracer particle in magnetic particle imaging and for hyperthermia-triggered drug release. Ligands for disease biomarkers identified by global protein quantification will ensure targeted delivery of the theranostic SPION. We will push the frontiers of magnetic bioimaging for non-invasive and accurate diagnosis of IBD to guide stimuli-responsive drug delivery. To optimize the treatment of sick children, we will design personalized oral dosage forms incorporating our targeted drug carriers by additive manufacturing. The nanoengineering approach along with industrially relevant microencapsulation and 3D printing technologies will provide fundamental insight into physicochemical properties that govern the targeted use of nanomaterials in the challenging GIT environment. The outcome of this research will support personalized therapy of pediatric IBD, improving patient quality of life and reduce the healthcare burden.
Understanding the discourse-semantic shift towards risk in the UK and Germany (UnRi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-12-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project aims to advance our understanding of the forces that have driven the proliferation of risk discourses in the UK and Germany since World War Two. Working at the boundaries of risk sociology and corpus linguistics, this is a highly innovative enterprise, both theoretically and methodologically. It will examine the contribution made by main-stream risk theories to explaining the increasing use of the risk semantic in media coverage during the last 50 years, and it will develop an empirically grounded theory of the observable shift towards risk. The Fellow will utilise cutting-edge corpus-based research strategies to systematically reconstruct the changing use of the discourse-semantics of risk and will complement these with interviews of media experts to examine how these changes are linked to institutional and socio-cultural changes and historically significant events. The Fellow is an outstanding scholar in risk studies who will further develop his skills and expand his networks among eminent European sociologists and corpus linguists. The IF will be placed with Prof McEnery, a leading scholar in corpus research at Lancaster University, who is the Director of the ESRC Centre for Corpus Approaches to Social Science (CASS). This will be complemented by a secondment with Prof Kämper, an expert in historical linguistic change, at the Institute of German Language (IDS) in Mannheim. Both these opportunities will allow the Fellow to build on existing networks with scholars working in the maturing domain of corpus-driven social science research. Working with corpus based discourse analysts and computational linguists at CASS and IDS will allow the Fellow to firmly establish his skills in the application of corpus based discourse analysis within the social sciences and will enhance his opportunities to reintegrate into the European academic community.

Keywords: risk,social change,international comparison,discourse semantics,corpus linguistics,computational linguistics
medical Diagnosis Support Armchair project (DISA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The “Diagnosis Support Armchair” project aims at collecting, in a very short time (7minutes max.), all medical data from the elderly person’s body and send them to the nearest medical center or doctor. This could allow an easy follow-up of chronical diseases in nursing or elderly residential homes and give all necessary elements to establish a diagnosis and make a quick decision. Beyond the elderly population, this type of connected e-health armchair can be used with any age population in all medical and emergency centers. The specific objective of the feasibility study is to evaluate the armchair interests for patients and get support from medical professionals at French and European level. With the development of many non-invasive sensors on a mobile and easy-to- use armchair, StreamVision wants to facilitate the work of many medical helpers by bringing in a very easy, quick and accurate manner an answer to medical deserts in remote regions or countries. To do so, StreamVision proposes to work with emergency hospitals and nursing homes so as to define and validate the various non-invasive sensors necessary to make the chair useful. This feasibility study with medical players must help Streamvision to develop scenarios of industrialization and commercialization at EU level. Several steps must be accurately designed such as : protocols, user and medical players involvement and acceptance, standardization and certification process, business model and obviously security in the medical environment. This study will comply with the French national law (the CNIL) and there is no specific ethics issues excepted the elements mentioned in the proposal.

Keywords: silver economy,health,medical diagnosis,support,new product,new device,non invasive sensors,autonomy of elderly people,easy and remote follow up of chronical diseases,nursing home
UltraCLEAN thermoforming equipment for ultraclean PACKaging of foods, and in-situ production of aseptic trays. (CLEANPACK)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With this CLEANPACK project we, TECSELOR, will put in the market a thermoforming machine that manufactures ultraclean packaging trays, oriented to fresh food products. The machine can be used for aseptic tray manufacturing or for the whole process of food packaging, coupling the adequate module (vacuum, modified atmosphere, etc). Our aim is to reduce the presence of pathogens and spoilage organisms in fresh packed foods, having the biggest impact in foods that are consumed without a cooking step, offering a cost-effective, eco-innovative and energy saving alternative to clean rooms, which are very useful in food industry but expensive to build and maintain. TECSELOR is a Spanish SME founded in 2003 settled in Murcia, dedicated to the design and production of several kinds of food packaging machinery –thermoformers, thermosealers, shrink wrappers vacuum packaging-. Our SME is composed by highly educated personnel, with a vast experience of 12 years in average. We are 37 employees, and our revenue in 2013 (last registered financial data) was €4,250,811.59. The general objective of this project is to bring to the market a thermoforming food packaging machine for in-situ production of aseptic trays oriented to diminishing food borne diseases and food waste, and increasing shelf life in fresh foods products. CLEANPACK will render in the first five commercialisation years an accumulated revenue of €26,800,000 and an accumulated profit of €8,275,000 by selling 67 machines.

Keywords: food packaging machinery,ultraclean,aseptic,food safety,fresh food,food waste,food borne disease
Second funding line in 2015 for the establishment of a European SST Service provision function (2SST2015)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Spain,Italy,Germany,France,United Kingdom,United Kingdom
Call: SPACE (H2020-Adhoc-2014-20, 2015)
Start date: 2016-01-01
End date: 2017-06-30
Duration (months): 18.0
Total project cost (EUR): 3199997.75
EU funding (EUR): 3199997.75
Participants: 11
Project status: CLOSED

The main objectives of 2SST2015 are the initial networking of SST assets and preparation of the establishment of a European SST Service provision function. The project is the first of a series in the upcoming years and has to be seen in context with two parallel projects for initial service provision and for SST roadmapping and infrastructure.

Keywords: space surveillance and tracking,space debris,reentry monitoring,cooperation of member states
Identification of novel genes and mechanisms for PCD and male infertility (PCDfert)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-11-22
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Human health issues due to genetic causes induce prominent costs for the society and cause serious health problems. Therefore, this project aims to train the Experienced Researcher in human molecular genetic studies to identify genetic causes for inherited defects and utilize the previous knowledge of the Researcher in molecular genetics of spermatogenesis to establish causes of human male infertility. Specifically this study uses a unique Primary Ciliary Dyskinesia (PCD) patient cohort for identification of novel causative mutations and their roles in cilia. PCD is characterized by recurrent infections of the respiratory tracts starting soon after birth, which without early intervention will develop into severe respiratory disease. The functionally similar microtubular core structure (‘axoneme’) of cilia and sperm tails required for their motility means that compromised ciliary function may also be a cause of male infertility. For the first time the effect of PCD mutations on sperm development will be examined, which is crucial for consultation of PCD patients for their fertility status. These experiments will also provide data for genetic causes of male infertility and allow development of a gene panel for specific sperm defects. To further gain expertise in state-of-the-art methods and research objectives, the Researcher will familiarize in high resolution imaging and investigates the transition zone (TZ) structure in developing sperm. TZ has been recently shown to be indispensable structure controlling the protein transport to cilia, but its role is poorly understood and not known in sperm. Thus, this project will produce novel insights into the mechanisms of cilia and sperm tail formation and enhance the career prospect of the Researcher through extensive training and state-of-the-art research plan. The fellowship enables integration of the Researcher within the Cilia research group in UCL and future senior fellowship application to UK based foundations.
Mathematical study of Boundary Layers in Oceanic Motions (BLOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1267500.0
EU funding (EUR): 1267500.0
Participants: 2
Project status: CLOSED

Boundary layer theory is a large component of fluid dynamics. It is ubiquitous in Oceanography, where boundary layer currents, such as the Gulf Stream, play an important role in the global circulation. Comprehending the underlying mechanisms in the formation of boundary layers is therefore crucial for applications. However, the treatment of boundary layers in ocean dynamics remains poorly understood at a theoretical level, due to the variety and complexity of the forces at stake. The goal of this project is to develop several tools to bridge the gap between the mathematical state of the art and the physical reality of oceanic motion. There are four points on which we will mainly focus: degeneracy issues, including the treatment Stewartson boundary layers near the equator; rough boundaries (meaning boundaries with small amplitude and high frequency variations); the inclusion of the advection term in the construction of stationary boundary layers; and the linear and nonlinear stability of the boundary layers. We will address separately Ekman layers and western boundary layers, since they are ruled by equations whose mathematical behaviour is very different. This project will allow us to have a better understanding of small scale phenomena in fluid mechanics, and in particular of the inviscid limit of incompressible fluids. The team will be composed of the PI, two PhD students and three two-year postdocs over the whole period. We will also rely on the historical expertise of the host institution on fluid mechanics and asymptotic methods.

Keywords: boundary layers,fluid mechanics,mathematical analysis of oceanographic models
Structural and biochemical studies of an ancestral enzyme with dual dehalogenase and luciferase activity (Ancestral)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 142720.8
EU funding (EUR): 142720.8
Participants: 1
Project status: CLOSED

Haloalkane dehalogenases (HLDs) catalyse the cleavage of the carbon-halogen bond of industrial organohalogen compounds and are interesting subjects to study molecular evolution. Strikingly, HLDs display remarkable sequence and structural similarity with luciferase from the marine invertebrate Renilla reniformis (RLuc), which reflects their common evolutionary history. Unlike HLDs, which are α/β hydrolases (EC 3.8.1.5), the RLuc luciferase is cofactor-independent monooxygenase (EC 1.13.12.5) that converts coelenterazine into coelenteramide and carbon dioxide, followed by an emission of blue light. Yet, the evolutionary steps driving their functional divergence remain poorly understood. Our proof-of-concept data show the feasibility of the reconstruction of an ancestral enzyme, which existed prior to the functional divergence of the modern-day HLD and RLuc homologues, and that this in-lab resurrected enzyme exhibits so-far unobserved dual dehalogenase/luciferase activity. This project aims to dissect structural and biochemical basis of this unusual biocatalytic behaviour of the ancestral enzyme. Specifically, X-ray crystallography, including time-resolved studies with photo-switchable substrate analogues, and advanced mass spectrometry techniques will be employed to probe enzyme-substrate complexes in order to get molecular insights into the inner organization and workings of the catalytically promiscuous enzyme. Complementary site-directed mutagenesis and molecular dynamics simulations will explore the contributions of individual amino acid residues to the dual-function activity. The gained knowledge will extend our in-depth understanding of the evolution of underlying biocatalytic reaction mechanisms. Furthermore, it will pave the way for the development of novel software tools for the rational engineering of next-generation biocatalysts for specific uses in biotechnology and biomedicine.

Keywords: haloalkane dehalogenase,renilla luciferase,molecular evolution,ancestral sequence reconstruction,promiscuous catalysis,structural biology,crystallography,protein engineering
The Application of Advanced Raman Spectroscopies to the Quantitative Analysis of Industrial Chromatography Columns (RICC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Dr. Kevin Buckley (KB) was awarded his PhD from University College London (UCL) in 2011. At UCL he had worked to develop Raman spectroscopy as a tool for bone-disease diagnosis and he subsequently took a position as a Laser Spectroscopy Scientist, at the Rutherford Appleton Lab (RAL) in Oxfordshire, England, to continue this work. After leaving RAL, KB moved to the University of British Columbia (UBC) in Vancouver, Canada. At UBC he worked to develop a Raman spectroscopy-based instrument for detecting chemical changes in (donated) human red blood cells as they age in plastic blood-bags. He has recently (Aug 2015) returned to his home country of Ireland and the primary aim of the proposed Marie Skłodowska-Curie Fellowship is to reintegrate him with the research community there. The primary scientific objectives of the fellowship to develop novel analytical methods based on Spatially Offset Raman Spectroscopy (SORS) for applications in biopharmaceutical manufacturing. It is proposed that this interdisciplinary research take place under the supervision of Dr. Alan Ryder (AR) in the Nanoscale Biophotonics Lab (NBL) at the National University of Ireland, Galway. The combination of KB’s SORS expertise with AR’s biopharma expertise has the potential to deliver innovative science; KB is one of the few researchers in the world who has years of experience with SORS of complex materials (he trained under the inventor of SORS, Prof. P. Matousek FRSC, at RAL) and AR is an international leader in the development of quantitative analytical methods for biopharmaceutical manufacturing processes. In addition to scientific objectives, the fellowship programme has been designed to develop KB’s career and enhance his ability as a scientist. He will be provided with opportunities to develop academic teaching skills and will prepare a specific career development strategy. AR will also mentor KB as he prepares post-fellowship grant proposals and begins his independent academic career.

Keywords: raman spectroscopy,spatially offset raman spectroscopy sors,biopharmaceutical manufacturing
NK receptors and disease (KIRANDIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 1735205.0
EU funding (EUR): 1735205.0
Participants: 1
Project status: SIGNED

NK cells are relevant to many kinds of disease, including viral infection, autoimmunity, cancer, transplantation and reproduction. The behavior of NK cells is controlled by a large number of different cell surface receptors, in a region on chromosome 19 called the LRC. Some of these receptors, such as KIR, are highly variable in gene number and allele sequence in different individuals. Many of them interact with HLA class I molecules, which are also highly polymorphic. To understand and exploit NK receptors and disease this project has three aims: 1. To investigate how variation in receptors encoded in the LRC influences viral infection and disease course. My laboratory is known for high-throughput KIR copy number and allele typing. Highly polymorphic KIR receptors are refractory to analysis by SNP typing and next generation sequencing (NGS) methods, so interrogation of large numbers of samples for accurate disease determination is not feasible. To overcome this problem we propose to develop digital PCR, sequence-based allele typing, imputation and NGS after sequence capture. Once underway, a large number of disease cohorts and matched controls will be investigated, spanning autoimmunity, infection and birth-weight, in collaboration with other laboratories. 2. To investigate mechanisms viruses use to evade NK cells. To facilitate this we have generated reporter cells that permit weak interaction of receptors with their ligands to be detected by production of Green Fluorescent Protein (GFP). The evasion of NK cells by HCMV, vaccinia and HPV viruses will be studied. This work will be in conjunction with expert virology groups in the UK. 3. To identify novel ligands for LRC-encoded receptors. We will use the reporter cells to screen for ligands, initially by blocking binding with monoclonal antibodies. We intend to identify ligands for KIR and LILR, where these are unknown, especially focusing on activating receptors.

Keywords: natural killer cell