Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrafast Chirality for Life and Technology (TRILOGY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,France,Belgium,Italy,Israel,United Kingdom,Sweden,Switzerland,Netherlands,Austria
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4737902.14
EU funding (EUR): 4613499.72
Participants: 29
Project status: SIGNED

TRILOGY establishes the interface between the emerging field of Ultrafast Chirality and its Life and Technology applications by using attosecond electronic response to light, the fastest agent in mediating electric signals, highlighted by the 2023 Physics Nobel Prize. Chirality, a dissymmetry between a molecule and its mirror image, is a synonym of life: it enables metabolic reactions and stability of proteins. Abnormal chirality is an indicator for cancer cells, brain or kidney diseases, but its accurate detection requires a combination of high precision and speed, where attosecond response to light gives clear advantage to optical methods. Standard chiro-optical methods are fundamentally limited in accuracy by a ratio of molecular size to the light wavelength. Resolving ultrafast electron dynamics we remove this limitation and break into a new regime with chiral signals outperforming standard methods by several orders of magnitude. We will take advantage of this paradigm shift in chiral measurements and develop new efficient ultrafast spectroscopies for discriminating medium sized chiral biomolecules and elucidating charge and spin transport in chiral media at the most fundamental level: the level of electrons. We overlap the training and innovation landscapes in a unique way inspired by a common drive to bring cutting-edge scientific developments to applications, enabled by strong involvement of industry. We will (i) integrate our methods with existing analytics for quick market adaptation, working with the market leader for mass spectrometry (ThermoFisher), (ii) further them to unprecedentedly high throughput enabled by laser technology (Amplitude) and state-of-the-art imaging (PIimaging). We will make a difference, motivate and inspire young minds, training a new generation of researchers at the interface of fundamental science, technology and high-tech industry to bring cutting edge research through industrial applications to the benefit of the society.

Keywords: attosecond physics,molecular chirality,high harmonic generation,time resolved photoelectron spectroscopy
Smart pathology slide scanner for diagnosis and patient-specific treatment recommendation in oncology (CancerScan)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal,Spain,Italy,Germany,Austria,Serbia
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-08-01
End date: 2028-07-31
Duration (months): 36.0
Total project cost (EUR): 2980916.25
EU funding (EUR): 2980916.25
Participants: 8
Project status: SIGNED

Our long-term vision is to develop a smart digital pathology slide scanner that can (semi)automatically generate a patient-specific tumour digital twin and simulate various drug treatments on such twin. The digital twin will be generated by combining slide-level multi-omics profiling of patients’ biopsies with other standard clinical data and will be hardware-embedded within a slide scanner. This foundational architecture involves five pillars: experimental mapping of tumor communication, reconstruction of Biomedical Knowledge Graphs (KG) based on experimental data, identification of structural and temporal properties of communication networks, development of a mathematical framework for modeling treatment effects on a tumor, and the design of a novel hardware acceleration architecture for a medical digital twin. As a model system, we will use pancreatic cancer, combining in vitro experiments with clinical data. We will analyze how tumor microenvironment composition affects cellular crosstalk and drug efficacy by developing, growing, and treating a series of tumor organoids with different TME compositions, and performing a detailed molecular analysis of samples. Clinical validation will involve matching organoid and patient biopsy structures, ensuring relevance and applicability of our findings. This project is the initial step towards a platform assisting doctors in improving the diagnosis and assessment of drug treatment efficacy for individual cancer patients so that each patient gets the best possible drug, with the best possible treatment regimen.

Keywords: tumor microenvironment,cellular crosstalk,ai,digital slide scanner,tumor proto communication,digital twin
Highly multiplexed, quantitative protein biomarker profiling (hmqPro) (hmqPro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 201428.57
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The project will develop a multipurpose, highly multiplexed, quantitative protein profiling (hmqPro) platform that can be adapted to a wide range of applications, particularly biomarker discovery. Biomarkers are a 43 Billion USD market spanning applications in diagnostics, drug discovery & development, personalized medicine, disease risk assessment. The method comprises an antibody-based profiling of a large number of proteins or protein posttranslational modifications against a large number of samples irrespective of source. Unlike competitor methods, hmqPro does not require platform-specific assay or detection equipment. Dual multiplexing implemented in a variant method, hmqPro-2D, will make the platform competitive against existing protein profiling methods in per-assay cost, flexibility and scalability. The hmqPro platform uniquely complements the technology portfolio of Epigenica AB and we will chart out two commercialization routes: first, hmqPro will be integrated into a service laboratory offering high-throughput sample-to-result epigenome and protein profiling services to academia, pharma and biotech industries. Second, we will package the method in a kit format distributed to R&D and clinical end users. In summary, the proposed project will deliver a new quantitative protein profiling platform that will have the capacity to impact the biomarker discovery market by combining unique flexibility with high-throughput.
History, Archaeology, and Botany of Pacific Islands: assessing the Impacts of Early European colonialism on Peoples and Forests (PacificPeopleForest)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Netherlands,Belgium,Mexico,Singapore,Northern Mariana Islands,Guam
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 1752027.84
EU funding (EUR): 1752027.84
Participants: 12
Project status: SIGNED

PacificPeopleForest provides a critical new perspective on early Modern colonialism in the Pacific. Against mainstream assumptions that the 19th century marks the beginning of European impacts in the region, we rely on preliminary archaeological and historical evidence to propose that European contact in the 16th century had large demographic consequences undescribed so far, shifting the weight of human settlement from the inland areas to the coast until today. Early European colonialism also had unknown environmental impacts since the 16th and 17th centuries. As fluctuating demography led to the abandonment of inland areas, these were subsequently recolonized by forest. Thus, forests recognized today as native, might in fact be fairly recent, and heavily modified. Europeans introduced a very large number of plants that are nowadays not only staples, but also socially and symbolically key to most Pacific societies. These species had an unknown role in shaping the island ecosystems, and led to changes in sustainable agricultural practices. Both the early colonial demographic and environmental impacts remain largely unaddressed for the Pacific. The project will focus on the Mariana Islands to weave historical, archaeological, and plant-based scientific lines of evidence that uncover the history, extent and chronology of the impacts of European colonialism in the Pacific Islands. We will examine its influence on island demography, settlement patterns and vegetation dynamics, as plants are key elements of Pacific ecosystems. By integrating interdisciplinary perspectives in an innovative doctoral programme, this project seeks to offer empirically-based insights into the interplay between human populations and forest dynamics, around European contact. Providing fine-grained chronologies for demographic shifts and plant introductions can address current vulnerabilities in the archipelago, ie. exposure to climate change and demographic challenges faced by Pacific peoples.

Keywords: pacific islands,early modern colonialism,historical archaeology,ethnobotany,multi technique botany,demographic impacts,digital humanities
EBRAINS Preparatory Phase (EBRAINS PREP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Belgium,Norway,Spain,Netherlands,Switzerland,Sweden,Germany,France,Greece,Italy
Call: Preparatory phase of new ESFRI research infrastructure projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 21
Project status: CLOSED

This ESFRI Preparation Phase Project will place the EBRAINS research infrastructure (RI) developed by the Human Brain Project (HBP) on a sustainable footing. The new organisational framework will allow EBRAINS to evolve from the largely EC-funded, HBP-developed RI into a sustainable “Hub-and-Node” RI on the ESFRI Roadmap. The Operation Phase EBRAINS RI will serve the whole brain research community, rather than the needs of a subset of users within that community; this will be reflected in a broader offering of tools and services by the RI. The Operation Phase RI will focus more on the processing, managing and sharing of data of all sorts, even those generated outside the RI, but will retain an important role in providing cutting-edge data-generating tools and services. While staying true to its roots in supporting basic research, it will expand its activities to support clinical research and innovative exploitation of brain-related technologies. The evolving RI offering will be determined with the help of a new governance structure, which focuses on determining the priority needs of the broad brain research community. The Operation Phase EBRAINS will be funded primarily by long-term commitments by the EU Member States and Associated Countries that are home to a Node in the EBRAINS RI. Objective 1: To put in place a financial, legal and governance framework for EBRAINS and prepare a plan to ensure the sustainable offering of the Service Capability by the Central Hub and the Nodes. Objective 2: To obtain the legally binding commitment of EBRAINS Consortium Partners to offer services needed by the brain research community by setting up EBRAINS Nodes. Objective 3: To deliver a complete overall technical design and associated cost estimate for the Service Capability. Objective 4: To decide the legal structure that EBRAINS will adopt for the Operation Phase and produce draft statutes for EBRAINS in that structure.

Keywords: esfri,preparation phase,research infrastructure,organisational framework,governance,research community,brain science,neuroscience,neurotechnology,central hub,node,data,tools,services
The Formalist Tradition in Late Scholastic Philosophy: a Renaissance Forerunner of Formal Ontology (FORMALITAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

In this UCLouvain-based project, Claus A. Andersen will demonstrate the philosophical and historical importance of the “Formalist tradition” in Renaissance philosophy (esp. in the time span ca. 1480–1620). The concepts of identity and distinction are the key components in the “Formalist treatises” that enjoyed vast diffusion during the Renaissance, had roots in Late Medieval scholasticism, esp. in the works of the Franciscan Duns Scotus, and played a significant role in textbooks of scholastic philosophy in the 17th and 18th centuries. The Formalists discussed whether their doctrines constituted a discipline of its own, a “science of the formalities” that would correspond to what to-day goes by the name of “formal ontology”. The rise of a new metaphysical discipline needs to be part of what we know about the intellectual culture of the Renaissance. The Formalist tradition has mainly been studied through its strains of influence upon other scholastic currents of the Renaissance, but has not itself attracted the attention it merits. This project is innovative in its identification and elimination of this gap in our knowledge and in its focus on scholastic metaphysics during the Renaissance. The project will be supervised by Prof. Jacob Schmutz (UCLouvain); it is conceived as a part of an endeavor to establish an internationally attractive milieu for studies in Early Modern scholastic philosophy at UCLouvain and thus opens rich opportunities for future cooperation. The applicant and the supervisor share a deep interest in the intellectual culture in Early Modern religious orders and will together curate an exhibition in the Maurits Sabbe Library in Leuven that documents the intellectual culture of the Franciscans in Early Modern Leuven on the background of the wider Franciscan scholastic tradition. The project further includes a practical training programme, research articles, an online catalogue of Formalist literature, and a conference with a proceedings publication.

Keywords: formal distinction,scotism,scotist tradition,scholastic philosophy,metaphysics,ontology,renaissance studies,15th and 16th centuries,john duns scotus,franciscans,incunabula
Bone, Brain, Breast and Axillary Medical Microwave Imaging Twinning (3BAtwin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Portugal,Ireland,Italy
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1499999.26
EU funding (EUR): 1499999.26
Participants: 4
Project status: SIGNED

Medical Microwave Imaging (MMWI) is an alternative type of medical imaging which has shown promising results in a handful medical applications for the past 20+ years. The applications addressed in this twinning project are Bone, Brain, Breast & Axillary region (3BAtwin) diagnosis. MMWI is an attractive imaging modality due to its non-invasiveness, use of non-ionising radiation, no need for compression, low power and comparatively low-cost, when comparing to other imaging modalities. All these characteristics make MMWI an attractive imaging modality for screening of several diseases or conditions. In this twinning project, the main goal for the partners is to ultimately capacitate the coordinator with the various specific/fine knowledge and tools which will allow to accelerate MMWI from the research bench to the patient bedside. Researchers in FC.ID+CIENCIAS possess general knowledge within the MMWI field of research that allowed them to attain their current standing. However, their journey to establish a laboratory and reach their current position has been a lengthy process. The overarching objective of 3BAtwin is for FC.ID+CIENCIAS to gain excellence capacity in all sub-fields related to MMWI research, and become strong competitors in translating their unique breast and axillary region device to the hospital, which will be possible by further establishing a solid collaboration with project partners: University of Galway (GALWAY) in Ireland, and Politecnico di Torino (POLITO) in Italy. GALWAY and POLITO are two excellent research institutes, also working on MMWI projects with excellent knowledge in specific fields that are of interest to raise the profile of FC.ID+CIENCIAS. By leading 3BAtwin, gaining key knowledge and working alongside the excellent project partners, FC.ID+CIENCIAS will be well poised to achieve excellency, boost their research and innovation capacity and become a competitive national and international reference in the area of medical microwave imaging.

Keywords: medical microwave imaging,dielectric properties,antenna design,medical microwave systems,radar and tomography microwave imaging,clinical trials,scouting and technology transfer
Next generation HPC/QC in silico drug discovery platform for de novo design (ATLAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 4249375.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

ATLAS is a powerful in silico drug discovery platform leveraging the latest advances in high-performance and quantum computing. The platform is the result of decades of research by leading experts in molecular dynamics. The technology is grounded on over 100 peer-reviewed papers and two ERC grants. Our beta code has gathered important accolades like the prestigious ATOS-Joseph Fourier prize and first place at the foremost rational drug design competition—the SAMPL challenge. ATLAS can replace costly and laborious experiments. It can even run entire drug discovery campaigns in silico, reducing cycle times and cost by at least 50%. By 2027, we will have a 35-project portfolio, and the first ATLAS-generated compound will reach the clinic. Thereafter, our objective is to generate a new candidate every 18 months. That year, our team will surpass 50 people and we’ll expand into the US market. We aim at securing a leadership position in the nascent in-silico drug discovery market.

Keywords: drug discovery,molecular dynamics,quantum physics
Music that produces racial inequality? The impact of racist ideas on the conditions of existence of Afro-diasporic musicians in Peru (RACISMUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-07
End date: 2025-08-06
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

Racism permeates the everyday musical practices of Afro-Peruvian musicians, impacting their living conditions across class, gender, and phenotype. Informed by a colonial racist framework, Peruvian musicians, scholars, and aficionados have historically conceptualized Afro-Peruvian musical practices in terms of essentialist connections with Africa and black bodies; racial prejudices; and colonial social hierarchies. Such racialization of Afro-Peruvian musical practices entails that its practitioners must routinely address racist expectations and stereotypes, and the way they do so has material and emotional consequences for them. RACISMUS analyzes how racist ideas about Afro-Peruvian musical practices affect the living conditions of its practitioners, as well as the strategies they employ to resist or mitigate such impacts. Drawing on scholarship in ethnomusicology, historical musicology, and critical race theory, RACISMUS objectives are to produce empirical knowledge about: (a) the historical foundations of racist ideas that currently shape the artistic practice of Afro-Peruvian music; (b) how, in shaping their practice, those racist ideas impact the conditions of existence Afro-Peruvian music practitioners across class, gender, and color in a context of racial inequality and mestizaje; and (c) the agency of Afro-Peruvian music practitioners in addressing those racist ideas and their impact in their practice, including their decision-making processes, strategies, and resources.

Keywords: racism,race,peru,blackness,african diaspora