Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Twinning to build an industrial ecosystem around the core principles of Industry4.0 and the Digital Twin (Twin4Twin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Spain,Austria,Switzerland
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 4
Project status: SIGNED

CORE Innovation Centre (CORE) is a private non-profit research organisation, based in Greece and founded in 2021 as a full subsidiary of CORE Innovation Technology OE, focusing on Industry4.0 technologies, like machine learning, IoT, edge and cloud computing, Innovation Management and Communication. The vision of CORE is to become the biggest R&I centre in Southeastern Europe in the fields of Industry4.0. CORE aims to create an industrial ecosystem, composed of manufacturing companies and knowledge/research institutions, around the core principles of Industry 4.0 such as automation, zero-defect manufacturing, and flexible production based on a number of core technologies such as Machine Learning, Robotics, Big-Data and Digital Twins. This vision will be materialised through the development of Industry 4.0 Test Labs, which are practical environments where companies and research institutions develop, test and implement Industry 4.0 solutions under realistic conditions, as well as co-design the associated digital processes and new business models. The overall Twin4Twin goal is to raise the research profile of CORE as well as the research profile of its staff in the field of digital twin technologies. In parallel with the objectives, Twin4Twin’s concept approach is divided into four clusters: a. digital twins – scientific excellence b. research and innovation management upskilling, c. business development, and d. exploratory research project. To do that, CORE will run the twinning exercise with leading EU organisations, namely ITA from Spain (Reduced Order Models research in Digital Twins), SCCH from Austria (Big Data real time streaming technologies) and SSF from Switzerland (test and demo platform to be used as use case and provide the replication potential towards the Greek Smart Factory).Twin4Twin aims to reduce the disparity in production between Greece and top-class leading countries through knowledge transfer in smart manufacturing technologies.

Keywords: digital twin,industry 4 0,big data,machine learning,smart factory,manufacturing,upskilling,research and innovation,project management,partnership
Creating a Sustainable Functional Food Chain: A Pathway to EU Climate Neutrality and Improved Health (PATHFOOD)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Poland,Spain,Italy
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1607140.17
EU funding (EUR): 1498925.88
Participants: 4
Project status: SIGNED

PATHFOOD aims to revolutionise the field of selenium-enriched functional food, aligning with the European Union's strategic objectives for sustainable development, public health improvement, and socioeconomic growth, thereby strengthening the University of Warsaw's (UW) standing as a leading institution in this research domain. It is a conduit for knowledge transfer and capacity building with internationally leading partners. The project integrates multiple facets, from selenium sourcing with robust traceability systems to innovative crop cultivation methods that enhance selenium content while minimising environmental impact. Additionally, the project focuses on optimising food processing techniques to preserve selenium content and develop consumer-tailored functional food products. Advanced analytical methods such as high-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) will be utilised to scrutinise selenium content and its speciation. Regulatory compliance forms a cornerstone, ensuring consumer health and instilling confidence in selenium-enriched food products. Adding to these dimensions, PATHFOOD is committed to achieving gender and diversity balance within the consortium throughout the project's activities. All participating partners established policies (GEP) designed to foster gender equality, diversity, and inclusion amongst employees, enriching the project's social impact. Furthermore, the project espouses an Open Science approach, aiming to make the research process more transparent and collaborative. This will facilitate the sharing of methods, data, and findings with the broader scientific community, thereby accelerating the pace of discovery and ensuring that the research benefits are distributed more widely. The collective goal is to advance the frontiers of functional food development and foster global cooperation and innovation in the pursuit of healthier and more sustainable dietary choices.

Keywords: functional food,food chain,sustainable agriculture,nutrition,selenium enriched food,
Chip-based room-temperature terahertz frequency comb spectrometers (TeraERC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: SIGNED

Although visual perception of humans is limited to a fraction of wavelengths spanning the electromagnetic spectrum, technological advances enable us to see in other spectral regions by providing suitable sources and detectors. Of particular interest for many applications is the ability to probe objects in the terahertz (THz) range, which bridges the microwave and infrared domains. THz radiation offers unique opportunities for imaging or sensing due to its high transmission by optically-opaque materials like paper, textiles, ceramics or plastics, while for gas sensing it enables identification of structurally-complex molecules. Unfortunately, access to this region is difficult due to limitations of conventional electronics and photonics, and often involves cryogenic operation. Even the most mature systems operating at room temperature, despite years of advances, still struggle to provide chip-scale miniaturization of the source and detector, and moving-parts-free acquisition of a broadband THz spectrum. Here, to fill this niche and address the critical demand for broadband, chip-based THz spectroscopy without any moving parts, we propose to leverage mid-infrared (3-5 um) semiconductor laser frequency combs based on interband cascade lasers (ICL). We postulate that nonlinear frequency conversion due to the recently discovered second order susceptibility of the ICL medium can be used to obtain microwatt to sub-milliwatt level of THz power at a battery-compatible bias. A complementary mid-infrared photomixer technology envisioned in this proposal will additionally enable coherent detection of broadband THz comb radiation at room temperature. Although the project is inherently risky due to uncertainties in the ultrafast dynamics of semiconductor structures, losses in the terahertz range, and fabrication complexity, it is timely and strongly demanded by the community. It will unlock new opportunities across many disciplines ranging from chemistry to 6G telecommunications.

Keywords: interband cascade laser,nonlinear frequency conversion,difference frequency generation,optical frequency comb,far infrared region,optical spectroscopy
Beyond the chromosome: unravelling the interplay between inter-chromosomal genome architecture and mRNA biogenesis (TRANS-3)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1769998.0
EU funding (EUR): 1769998.0
Participants: 1
Project status: SIGNED

In TRANS-3 we will develop the theoretical and experimental framework to understand inter-chromosomal genome structure and activity. Despite advances in sequencing chromosomes and mapping their three dimensional (3D) organization, a full picture of 3D genome structure that details how the borders of various chromosome territories functionally interface one another is still missing. As an analogy, our world map does not indicate most natural corridors or manmade infrastructure that connect countries to one another. Worse, we barely understand how such connections function. My recent work has identified one of the few functional inter-chromosomal (trans) DNA interactions known to date: a splicing factory involving over ten chromosomes and orchestrated by the muscle-specific protein RBM20 around its key target, the TTN pre-mRNA. I hypothesize that this exemplifies how mRNA biogenesis instructs the formation of trans-interacting chromatin domains (TIDs) around mRNA factories, nuclear compartments that facilitate gene regulation. We will test this general hypothesis by dissecting the mechanisms and function of a specific, disease-relevant model: the RBM20 mRNA splicing factory. We will then explore the global impact of these regulations. First (WP1) we will mechanistically assess how mRNA factories form and act through live imaging of the nuclear positioning and alternative splicing dynamics of an RBM20-regulated locus. Secondly (WP2) we will examine the physiological role of mRNA factories by studying the effects of disease-associated mutations in RBM20 and the TTN regulator GATA4, and of genetic variability in TTN regulatory regions. Finally (WP3) we will develop and deploy a novel pipeline to identify, validate, and study new TIDs and mRNA factories through the combination of molecular biology, bioinformatics, biochemistry, and single cell biology. In all, TRANS-3 will venture beyond the chromosome frontier towards a deeper understanding of nuclear structure-function.

Keywords: chromatin organization splicing transcription dilated cardiomyopathy congenital heart disease human induced pluripotent stem cells genome editing single cell genomics
Diagnostics of aberrant cancer glycosylation signatures (SweetCancerTest)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cancer is a leading cause of death worldwide and novel diagnostic and therapeutic approaches are much needed. All living cells are covered with a dense layer of ‘sugar-coat’ that is altered in cancer. One of the hallmarks of cancer is the expression of aberrant cell surface glycosylation patterns compared to normal cells. Current antibody-based assays against cancer glycans are commonly utilized to monitor clinical response to therapy, however none is useful for early detection or diagnosis due to low sensitivity and specificity. We aim to develop cancer diagnostics based on signatures of carbohydrate-neoantigens. We developed a unique system to generate potent antibodies of high specificity and affinity against various cancer glycans. Such potent antibodies that recognize tumor-associated carbohydrate-neoantigens can potentially be used as novel cancer diagnostics. Such validated tools could be used to identify cancer at an early stage and also for optimizing therapy to patients of unique sugar-code signatures.
MANUFACTURING-AS-A-SERVICE FRAMEWORK EXPLOITING DECENTRALIZED SECURE DATA EXCHANGE PROMOTING SUSTAINABILITY AND CIRCULARITY (MEDUSA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Italy,Austria,France,Sweden,Germany,Netherlands,Bulgaria,Spain,Latvia,Ireland
Call: Manufacturing as a Service: Technologies for customised, flexible, and decentralised production on demand (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-10-01
End date: 2028-03-31
Duration (months): 42.0
Total project cost (EUR): 9091723.24
EU funding (EUR): 6925179.74
Participants: 19
Project status: SIGNED

The project's main objective is to develop a highly innovative, secure-by-design framework that fully exploits the MaaS paradigm. This framework will offer secure data exchange between companies and cutting-edge tools to enhance production efficiency and sustainability. The MEDUSA framework will establish a seamless connection between existing marketplaces, facilitating optimized production by leveraging users' machinery and shared resources from other manufacturers. All resources will be treated as part of a distributed Cyber-Physical System of Systems (CPSoS), maximizing production. The implementation of an automation layer will enable the exchange of real-time production data and asset monitoring, allowing for the tracing and optimization of the product life cycle. The framework will also support the implementation of a DPP and provide AI-based tools for manufacturers to support decision-making for production planning, remanufacturing, and machine reconfiguration, always being energy-aware.

Keywords: manufacturing as a service,automation,edge computing,dpp,lca,circularity,artificial intelligence,digital twin,optimization,llm,blockchain,fault detection
To be or not to be creative: A neurophysiological investigation of musical creativity through time estimation (NEUROMUSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 181423.68
EU funding (EUR): 181423.68
Participants: 1
Project status: SIGNED

Time flies when we are immersed in creative activities, often causing us to lose track of it. Creativity is a complex phenomenon that thrives at the intersection of novelty and usefulness; a golden ratio where innovative ideas meet real-world value. However, most scientific research to date has studied creativity as a single construct. Additionally, previous research neglected to address how the artist’s intention enables creativity. NEUROMUSE will bridge both gaps through an in-depth investigation of the relationship between the feeling of time passage and musical creativity. A novel Instructed Musical Creativity Paradigm (IMCP) is introduced, in which musicians are asked to create their own musical improvisations after being instructed to be or not be creative, followed by an assessment of their improvisations by an audience. IMCP uses time estimation to uncover how creativity alters time perception by affecting neurophysiological dynamics. NEUROMUSE proposes a comprehensive multi-method approach combining neurophysiology (electroencephalography, heart rate, skin conductance) and computational modelling, to reveal the key neurocognitive mechanisms behind the generation and aesthetic appreciation of music. NEUROMUSE involves the Multisensory and Temporal Processing Laboratory at Panteion University and the Psychophysiology Laboratory of the University Mental Health Research Institute in Athens (Greece), led by world-recognized experts and equipped will the relevant physiological instruments. NEUROMUSE will provide me with the key skills to enhance my career prospects, by building a competitive profile in an underfunded area like the arts. Thus, I will be better positioned to pursue funding opportunities and establish my own research group in the future. Ultimately, understanding how we generate and perceive art is crucial in a world where creativity is increasingly imperative, driving productivity and innovation in academia and industry.

Keywords: musical creativity,electrophysiology,time perception,eeg,musicians
Revolutionary high-resolution human 3D brain organoid platform integrating AI-based analytics (3D-BrAIn)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Italy,Switzerland,Germany
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2003347.5
EU funding (EUR): 1998347.0
Participants: 5
Project status: SIGNED

The long-term vision of the 3D-BrAIn consortium is to revolutionize personalized precision medicine for central nervous system (CNS) disorders, by developing an innovative bio-digital twin model of the human brain that is personalized, precise, and predictive. In this pathfinder project we bring together three breakthrough technologies: 1) a novel, highly reproducible human brain modelling technology using robust adherent iPSC-derived 3D cortical organoid cultures, 2) a unique, state-of-the-art 3D multi-electrode array (MEA) technology for non-invasive high-resolution electrophysiological recordings and 3) a novel approach to analyse and interpret the large quantities of functional data using tailored automated machine learning (ML)-based algorithms. With this breakthrough approach we overcome significant hurdles that made it thus far impossible to create a truly representative and functional model of the CNS for personalized medicine, drug screening and neurotoxicity testing. The revolutionary 3D-BrAIn high-precision CNS platform will allow robust and accurate modelling of the CNS for a broad range of neuropsychiatric diseases. Ultimately, the 3D-BrAIn technology will be translatable to multiple other organ systems (cardiomyocytes, pancreatic islets, retina), to non-invasively obtain longitudinal 3D high-resolution electrophysiological recordings and effectively interpret them. In this project a prototype of the 3D-BrAIn platform will be developed by growing functional 3D organoids that faithfully resemble the human cortex on 3D MEA micropillar electrodes, enabling continuous functional monitoring and by developing ML-based algorithms that can process and interpret the large spatiotemporal data sets. Once all individual components are optimized and integrated, proof-of-concept will be obtained by validating the platform for two of the envisaged applications: CNS drug development and neurotoxicity screening.

Keywords: 3d brain organoids,microelectrode arrays,personalized precision medicine,artificial intelligence ai,machine learning
Producing the Next Generation of Hybrid Animal-Free Cheeses (22-WTE-NTP)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-09-04
End date: 2024-09-03
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Nutropy is a French startup that develops the next generation of dairy and cheese alternatives. We produce bioidentical milk ingredients (proteins and fatty acids) to develop premium cheese alternatives that taste as good as conventional cheese but are more sustainable, healthier and better for the animals. This project is dedicated to the development of a new line of hybrid animal-free cheese alternatives containing pulses.

Keywords: animal free dairy,cheese alternatives,hybrid products,precision fermentation,biotechnology
Bioinspired Legged Underwater robots for Ecological monitoring and Exploration (BluE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: SIGNED

A deeper understanding of marine ecosystems is crucial to enforce protective actions and promote a sustainable exploitation of the oceans’ resources. Adequate spatial and temporal coverage of data can be obtained by resorting to a network of fixed and mobile platforms to combine the advantages of different types of units. Existing mobile platforms, such as autonomous underwater vehicles (AUVs) and seabed crawlers, present intrinsic limitations when operating in the benthic environment which can be overcome by underwater legged robots (ULRs). ULRs, with arthropod-like versatile locomotion, are not much affected by currents, drain little power while keeping a fixed position, exhibit a gentler interaction with the seabed and produce a lower acoustic signature in comparison with propeller driven vehicles. The BluE project aims at bringing the advantages of bioinspired ULRs in ecological monitoring applications by combining their capabilities with those of fixed and mobile platforms. This aim will be pursued by (1) demonstrating tethered integration of a bioinspired ULR with a fixed monitoring platform (i.e., underwater cabled observatory) to perform visual census of the ictic community, and by (2) implementing a collaboration between a bioinspired ULR and an AUV to demonstrate obstacle free navigation. To undertake this research, I will join the Marine Science Institute of the Spanish National Research Council, world’s expert in the ecology of the Mediterranean Sea. Additionally, I will carry out two secondments at the University of Girona and at the Polytechnic University of Catalonia to receive training on mobile and fixed monitoring platforms and gain access to unique facilities such as the AUV Girona500 and the OBSEA cabled observatory. This project will contribute to the development of new tools for underwater operations with potential impact in scientific and commercial sectors and will establish the proponent as a prominent researcher in underwater robotics.

Keywords: marine robotics,underwater cabled observatories,ecological monitoring,autonomous underwater vehicles auvs,marine ecology,benthic environment