Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MAterials design at the eXascale. European Centre of Excellence in materials modelling, simulations, and design (MaX)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Partnership: HPC PPP (cPPP)
Countries involved: Italy,Germany,Spain,Spain,Italy,Italy,Italy,Italy,Switzerland,Switzerland,Belgium,France,United Kingdom
Call: HPC PPP - Centres of Excellence on HPC (H2020-INFRAEDI-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-09-30
Duration (months): 46.0
Total project cost (EUR): 8496557.5
EU funding (EUR): 8496557.5
Participants: 16
Project status: CLOSED

The main goal of MaX is to allow the pre-exascale and exascale computers expected in Europe in the 2020’s to meet the demands from a large and growing base of researchers committed to materials discovery and design. This goal will be achieved by: i) an innovative software development model, based on the concept of separation of concerns, that will enable performance of the community codes on heterogeneous hardware architectures, without disrupting their internal structure, the richness of their simulation capabilities, and their distributed and open development model. In this way, the most important community codes for quantum mechanical materials modelling will be ready for pre-exascale machines by the completion of MaX programme, and prepared to be ported to new architectures as they will become available; ii) an integrated ecosystem enabling the convergence of high performance and high throughput computing, that will allow steering the millions to hundreds of millions of simulations that are needed to optimise the properties and performances of a material or a device, with robust and reproducible workflows, all contributing to an ever growing repository of curated data; iii) a new approach to scientific computing in which hardware and software are co-designed and co-developed taking into mutual account the constraints and goals; iv) innovative measures for easy access to materials science applications, for engaging academic and industrial communities and fostering a broader and diverse pool of well trained users and developers. All this is made possible by the coordinated effort of a team involving developers of the leading EU open source community codes in the materials domain, five leading European HPC centres, two technology partners, and training and communication experts. MaX is fully aligned with the long term European HPC strategy and community, and to the work program call INFRAEDI-02-2018 – Subtopic (a), area 5 (Materials …).

Keywords: materials science,high performance computing,high throughput computing,co design,first principles calculations,electronic structure,extreme scale computing
Modular and Integrated Digital Probe for SAT Aircraft Air Data System (MIDAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy
Call: Development of Digital Integrated Multifunction Probe for Air Data Sensing [SAT] (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 1154375.0
EU funding (EUR): 948687.5
Participants: 3
Project status: CLOSED

The main objective of the MIDAS project is to design and manufacture a smart and fully integrated air data probe (ADP) for SAT applications, characterized by the following features: • reduced size and weight; • reduced power consumption; • improved reliability; • fully-integrated with the onboard communication bus; • fault tolerant, thanks to the health monitoring functionalities: The ADP will be delivered after: • a thorough test campaign for verification and validation of the manufactured system; • environmental requirement verification (Temperature, Vibration, Icing, EMI/EMC). Quality is ensured by the documented traceability of measurement results. In order to achieve these targets, the solution will include key enabling innovative technologies such as: • single Line-Replaceable Unit (LRU) with the capability of communicating with other FBW control system devices through a standard legacy (e.g. Arinc429, CanBUS Arinc825) and innovative communication bus (e.g. AFDX). As a further step it may be evaluated the introduction of a AFDX over fibre link channel to furtherly drastically reduce wiring weight on the aircraft, signals crosstalk and susceptibility and to increase the overall system reliability; • optimized fail-safe architecture; • innovative air data strategies to implement virtual sensors with the aim to reduce the use of physical probes; • redundant power supply and advanced health monitoring (hardware and software) based on previous partners’ experience exploiting power-up, initiatial and continuous built-in test; • advanced air data algorithms focused on air data system optimization, based on partners’ previous experience; • anti-ice capability using automatic heater in order to avoid holes occlusion due to ice formation; • complete sensors characterisation, calibration and target uncertainty evaluation.

Keywords: air data probe,fully integrated,qualified
Rituximab in patients with acute myocardial infarction: a phase 2 placebo-controlled randomised clinical trial (RITA-MI 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Israel,Sweden,France,France,Czechia,Netherlands,United Kingdom,United Kingdom
Call: New interventions for Non-Communicable Diseases (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 6583216.5
EU funding (EUR): 6583215.75
Participants: 14
Project status: SIGNED

RITA-MI 2 will assess the impact of a novel therapeutic strategy targeting patients’ immune response on the recovery of heart function after myocardial infarction (MI) in a phase 2 clinical trial. Cardiovascular diseases (CVD) represent a major cause of morbidity and mortality worldwide. Despite important advances in the treatment of acute MI, the occurrence of MI still results in left ventricular dysfunction in up to 50% of patients, which leads to the development of heart failure. Left ventricular dysfunction is the strongest predictor of adverse outcome after acute MI, and is associated with a 3 to 4-fold increase in mortality risk. In Westernised countries, heart failure is responsible for 1-2% of all health expenditure, which is mostly driven by repeated hospital admissions. Therefore, there is a considerable need for new therapies to limit the burden of CVD. This application builds on a ground-breaking discovery by a unique team of clinicians and scientists who provided extensive validation for their findings through a series of basic, pre-clinical and translational research. Our goal is to translate this discovery into benefit for patients. The new therapy is based on selective targeting of a specific immune cell subset, mature B lymphocytes, with the aim to limit deleterious cardiac remodelling and improve heart function recovery post-MI. Of note, the drug that targets this pathway, i.e., CD20 monoclonal antibody (mAb) rituximab, is available for testing in a re-purposing scheme, allowing for rapid initiation of proof-of-concept clinical trials. The PIs of the present proposal have successfully completed a phase 1/2a clinical trial (RITA-MI, NCT03072199), which established the safety of rituximab treatment at the acute phase of MI. RITA-MI 2 will conduct a phase 2b randomised double-blind placebo-controlled CT to assess the impact of B cell depletion with the CD20 mAb rituximab on left ventricular dysfunction and cardiac remodelling after acute MI.

Keywords: cardiovascular,myocardial infarction,immunotherapy,phase 2 clinical trial,drug repurposing,rituximab,left ventricular dysfunction,cd20 mab,mature b lymphocyte,single infusion treatment
Hydrothermal synthesis of ThermoElectric Chalcogenide-based Nanocomposites (HyTeChaN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Thermoelectric modules enable the direct conversion of waste heat into electrical power and could therefore represent a powerful in the energy transition and the move towards a more sustainable society, if we can find efficient and non-toxic materials scalable at the industrial level. The host team has recently developed two promising families of materials, namely p-type BiCuSeO-based and n-type AgBiCh2-based materials, which are among the best lead-free materials in their temperature range. Further improvements of their performances would pave the way towards applications. In the past few years, nanostructuration has revealed itself a powerful tool for the enhancement of the thermoelectric materials performances. In that framework, the use of this technique to improve the performances of BiCuSeO-based and AgBiCh2-based materials appears appealing. Therefore, the main goal of this project is to use hydrothermal chemistry, an easily scalable synthesis process, in order to synthesize bulk pellets of BiCuSeO/graphene and AgBiCh2/graphene nanocomposites, with improved thermoelectric performances. Besides its scalable character, the use of hydrothermal synthesis has many advantages, including a very fine control of the materials size, morphology and composition. Besides synthesis, the project will include a precise characterization of the chemical composition, crystal structure and microstructure of the materials, as well as an optimization of their thermoelectric performances. Besides scientific research, several outreach activities will be implemented in order to make thermoelectricity better known by the public, including the design of demonstration kits that will be made freely available.

Keywords: thermoelectric materials,hydrothermal synthesis
Hopfield neural network dynamics in open quantum systems (HopeQNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-03
End date: 2019-11-02
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Understanding how quantum effects can improve the performance of actual computing devices is an exciting and growing research area. However their role in neural networks (NNs), the complementary information process paradigm of classical computation is largely unexplored. The full translation of this paradigm at the quantum level ultimately requires to combine disordered spin-systems techniques, widely used in the study of classical NNs, together with the open quantum systems (OQSs) framework, in order to achieve their irreversible and non-linear dynamics. HopeQNet is the first step of an ambitious program that will lead, in a long term effort, to a new generation of quantum computing architectures, and is designed to deliver a first initial theoretical framework to investigate quantum effects in NNs, by considering the open quantum generalization of one of the most celebrated paradigms of NNs, the Hopfield model. This workhorse model will be simple and rich enough to: (i) apply well-developed tools from the theory of OQSs and establish a meaningful framework for a quantum NN; (ii) evaluate the potential gain due to quantum effects in this specific quantum NN architecture; (iii) engineering and modeling a proof-of-principle experiment of a Rydberg quantum simulator implementing it. HopeQNet combines the knowledge of the Applicant, who pioneered the use of disordered spin-systems in quantum many-body optical systems during his PhD (and will provide to the Host this unique expertise), together with the internationally recognized experience of the Supervisor in open quantum many-body systems and Rydberg atoms (who will mentor the Applicant throughout the training-through-research activity proposed here). This interdisciplinary combination of expertise is uniquely suited to carry out this first step of an ambitious 5-to-10 years program that will lead the Applicant to join one of the major EU institution working on quantum theory as an independent scientist.
The diffusion and nanoclustering of a polarity module in the lipid environment (Lipid and Polarity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Cellular polarity is a universal feature of eukaryotic biology. Failure to control cell orientation has dramatic consequences on embryogenesis and diseases including cancer. The establishment of cellular polarity often entails the asymmetric distribution of plasma membrane (PM) lipids signaling proteins and vesicle trafficking. The function of Rho proteins in cell polarity has been demonstrated from mammalian cells to yeast. The small GTPase Cdc42 is a pivotal regulator of polarity establishment and maintenance. A central feature of Cdc42 function is its ability to interact with membrane. In budding yeast, Cdc42 localizes asymmetrically at the PM, at the pole of the cell, along with the scaffold protein Bem1 and the Cdc42 activating GEF Cdc24. The asymmetric distribution of lipids in the internal leaflet of the membrane play a crucial role in the regulation of Cdc42 activity and localization, though the mechanisms are not completely understood. The organization of lipids in the PM influences the spatial distribution and activity of key signaling proteins as Ras family proteins. Ras forms nanoclusters in cell membranes that are essential for signaling and Phosphatidylserine lipids have been shown to play a role in the assembly of K-Ras nanoclusters in mammalian cells. In this work, we will study Cdc42, Cdc24 and Bem1 dynamics in the membrane and particularly at the polar cap. To address these challenging questions, we will be using lipid mutants (cho1∆, psd1∆ psd2∆…) in Saccharomyces cerevisiae. We are tracking Cdc42 polarity module components in these mutants at the single molecule level by super-resolution imaging in live cells. This system enables the quantification of the diffusion and clustering of individual molecules at the PM, and the contribution that the lipid environment imparts in vivo. In addition, using this powerful system, we will analyze the nano-organization of different phospholipids involved in signaling (PS, PE, P(I4,5)P2, PI4P).

Keywords: lipids,polarity,single molecule tracking,super reolution,palm,saccharomyces cerevisiae
Stilbene and entomopathogenic nematodes: Unlocking the potential (STEPN-UP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Bacteria frequently form intimate associations with a eukaryotic host where they may have critical roles in the development, behavior, and/or functions of their animal symbiont. While the underlying molecular mechanisms are poorly understood there is increasing evidence that the bacteria are employing proteins or molecules to send signals to their host. My goal is to understand the inter-kingdom signalling that occurs between a bacterium and its animal host using, as a model, the interaction between an entomopathogenic nematode (EPN) called Heterorhabditis and its symbiotic bacterium, Photorhabdus. EPNs are soil-dwelling organisms that utilize a bacterial symbiont to kill their insect targets. Photorhabdus produces a bioactive secondary metabolite called stilbene (ST). ST is used as an antibiotic and a virulence factor. Furthermore, ST is required for nematode growth and development suggesting that ST may be an important inter-kingdom signalling molecule. In this vein, the proposed project will investigate fundamental aspects pertaining to host-symbiont evolution and interactions by: 1) investigating the evolutionary history of ST synthesis proteins, 2) determining the nematode response to ST, and 3) engineering increased ST production. Aside from scientific advances, this fellowship would enable me to attend University College Cork (UCC) where beneficial training and knowledge will be obtained. For example, UCC provides training workshops on presentation skills, project management, and grant writing among others and aids in career management plans. Furthermore, I will learn new laboratory techniques and knowledge from this project. On the other hand, I will be able to bring my expertise in bacterial research to the host laboratory. This fellowship will have a significant impact on my career as an independent research scientist and will provide me opportunities to interact with the general public to enhance an overall knowledge of science.

Keywords: inter kingdom signalling,entomopathogenic nematodes,photorhabdus
Large Passenger Aircraft Innovative Aircraft Demonstrator Platform (GAM-2020-LPA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Spain,Italy,Germany,Germany,Italy,Norway,Norway,Belgium,Poland,Poland,Romania,Sweden,Sweden,France,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Large Passenger Aircraft ITD GAM 2020 (H2020-IBA-CS2-GAMS-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 228776991.75
EU funding (EUR): 170619810.19
Participants: 74
Project status: SIGNED

Main objective for the Clean Sky 2 Large Passenger Aircraft Programme (LPA) is to further mature and validate key technologies such as advanced wings and empennages design, making use of hybrid laminar airflow wing developments, the integration of most advanced engines into the large passenger aicraft aircraft design as well as an all-new next generation fuselage cabin and cockpit-navigation. Dedicated demonstrators are dealing with Research on best opportunities to combine radical propulsion concepts, and the opportunities to use scalled flight testing for the maturation and validation of these concepts via scaled flight testing. Components of Hybrid electric propulsion concepts are developed and tested in a major ground based test rig. The LPA program is also contributing with a major workpackage to the E-Fan X program. The R&T activities in the LPA program is split in 21 so-called demonstrators. In the project period 2020 and 2021 a substantial number of hardware items ground and flight test items will be manufactured, assembled tested. For some large items like the Multifunctional Fuselage demonstrators or the HLFC wing ground demonstrator the detailed design and manufacturing of test items will be commenced. For the great majority of contributing technologies a Technology Readyness level (TRL) 3 or 4 will be accomplished or even exceeded. Based on data generated for each key technology contributing to the LPA program inputs will be provided to the CleanSky Technology Evaluator via the integration in agreed concept aircraft models in order to conduct the overall CS2 assessement. LPA is also contributing to conduct Eco Design Life Cycle assessements for selected LPA technologies.

Keywords: large aircraft,large scale demonstration,integration of innovative propulsion concepts,hlfc,multifunctional fuselage demonstrator,wing design,advanced cabin design,disruptive cockpit
The molecular drivers of deep-sea adaptation in brittle stars (DEEPADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2022-01-20
Duration (months): 36.0
Total project cost (EUR): 270918.0
EU funding (EUR): 270918.0
Participants: 2
Project status: CLOSED

The deep-sea covers about two-thirds of the world’s ocean bottoms; yet, it is one of the least known environments of the planet. Given its harsh environmental conditions, life in high depths requires several specific metabolic adaptations. Surprisingly, little is known about the molecular mechanisms underlying adaptation to such environments. Which and how many genes are involved in adaptation? What is the extent of convergent evolution across distantly related taxa? Brittle stars (Ophiuroidea) are a useful group of marine invertebrates to study for this purpose, as they are abundant in the deep-sea and they colonized this environment several times independently, thus highlighting their strong adaptive abilities. Here, I intend to investigate deep-sea adaptation using a comparative genomics approach and state of the art analytic tools. I will first use an existing dataset to examine adaptive protein evolution (genealogical discordance and positive selection), by comparing 400 genes across 800 species of shallow- and deep-water brittle stars spanning the entire Ophiuroidea diversity. I will then focus on five cryptic species complexes representative of the major bathymetric transitions, by analyzing >10,000 genes generated from exon-capture and focusing on specific candidate genes. Finally, I will investigate allele frequency shifts among depths for two species displaying a wide bathymetric range using a genome scan approach (generation of two high-quality reference genomes; whole genome resequencing for 120 individuals). With these three approaches spanning a wide phylogenetic range, I intend to decipher the molecular mechanisms underlying deep-sea adaptation. This is of high importance because deciphering mechanisms of stress-driven adaptation may provide hints on the resilience of deep marine biodiversity to the ongoing environmental changes. Keywords: deep-sea; adaptation; phylogenomics; genome scan; positive selection; exon capture; Ophiuroidea; echinoderms

Keywords: deep sea,adaptation,phylogenomics,genome scan,positive selection,exon capture,ophiuroidea,echinoderms