Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Repair capacity and genome diversity in mammals (ReCAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1997592.92
EU funding (EUR): 1997592.92
Participants: 1
Project status: SIGNED

Genome evolution is driven by the generation of diversity. In mammals, genome diversification occurs in germline during the specialised division (meiosis) in gametes, when chromosomes recombine and assort into new haploid sets as they are passed from parent to offspring. Recently, the traditional view that genome diversification occurs exclusively in the germline has been challenged by findings that mutations in early embryos may cause predisposition to childhood cancers. We are uniquely placed to explore genome diversification in the germline and early embryos due to our breakthroughs in developing single-cell genomics and reproductive technologies. Our strategic aim is to uncover the capacity for genetic diversity in the human genome and investigate how DNA repair capacity in adult oocytes and early embryos facilitates genome stability. This will allow us to identify the selective forces that shape the genomic landscape in humans. Based on preliminary data, we hypothesize that repair capacity determines reproductive fitness of mammalian females, and that impaired repair capacity may underlie infertility, miscarriage, and congenital disorders. In Objective 1 we focus on adult oocytes, their survival in the adult ovary and the maintenance of genetic quality as women age. Objective 2 investigates genome diversification and stability in early embryos and putative ‘self-corrective’ mechanisms that restore the genetic quality of embryos. This proposal will shed light on a poorly understood area of enormous socioeconomic and medical importance.

Keywords: meiosis,dna damage response,chromosome segregation,genomics,human oocytes,genome stability,recombination,evolutionary genetics
Cold Atmospheric Plasma (CAP) sterilization of powdered products: optimization and validation at alimentary and pharmaceutical levels (CAP-SAliPharm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Insight market requirements are leading the R&D at food technology area to provide ready-to-eat products, microbiologically safe, with organoleptic and nutritional added value, and as longest as possible shelf-life guided by international trade search of competitiveness. Powders are worldwide distributed commodities. Valuable properties associated to them are: stability; easy storage and transportation; nutritional compounds integrated in formulas; price; and limited microbial proliferation. In spite of these characteristics, nowadays the sterilization of powders is not completely solved. Spore-forming bacteria are widely capable to survive in powders during long periods of time, initiating after the rehydration process, a rapid germination and proliferative activity with fatal consequences mainly in infant and elderly. The present project aims to analyse the Cold Atmospheric Plasma (CAP) technology application integrating the study of process parameters and reference powders characteristics to optimize the sterilization process of alimentary and pharmaceutical products. Moreover, the optimized conditions will be validated in real matrices, infant powder (milk formula and cereals) and multivitamin and protein complexes. Finally, the optimized conditions at pre-industrial level will be delivered in technical sheets regarding the technological, microbiological and risk-assessment relevant outputs of the project, contributing to provide the methodological basis for the industrial establishment of more sustainable production of a new generation of powdered products. Such system for powders sterilization has not been described previously and is one of the most ambitious points of research in the present MSCA framework. The present project aims to contribute to the cutting-edge of this technology application at International level, making a significant impact on the position of the European Union in the know-how regarding CAP application.

Keywords: powders,sterilization,cold atmospheric plasma,non thermal technology,risk assessment,nutritional compounds
Borelli Galaxy. Visualizing Galileo's Heritage (1635-1700 ca.) (BorGal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-10-16
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

BorGal orbits around the figure of the italian physiologist, physicist, and mathematician Giovanni Alfonso Borelli (1608-1679). He was the only one among the Galileo’s disciples to cross the disciplinary boundaries and to apply the master’s teaching to the different branches of scientific research. Like Galileo’s, his sperimentalism mantained a strong theoretical and ‘ideological’ committment; he pursued with extraordinary energy and method an overall strategy to spread the credo of the new philosophy in all fields of scientific investigation, in all Italian Universities (especially in the Mediterranean area) and even in the ‘public sphere’. Despite his unquestionable value, this figure has not yet been the object of a monographic project. BorGal will accomplish this necessary task to make clear to everybody the importance of B.’s in the making of European scientific thought and community. I aim to achieve these goals by employing and enhancing Borelli’s still neglected correspondence, and in particular: to recover it by merging published, unpublished and still-to-be-discovered letters; to process the correspondance-data through the methodology proposed by the Mapping the Republic of Letters Project sited at Stanford History Department. Once in the US with the support of the GF, thanks to the powerful desktop application and programming languages for data visualization developed by the MRofL team with the support of the Stanford Center for Spatial and Textual Analysis, I will be able to map, chart ‘heuristically’ visualize and make visible to others the spatial multifaceted dimentions of ‘B.’s galaxy’ (places, people, works, letters, instruments, objects, information…), as well as the way ‘Galileo’s heritage’ took shape circulating across it. Last but not least, this B’s epistolary – by means of BorGal - will allow us to connect to the European ‘Republic of Letters’ an alleged marginal area like Spanish Sicily.

Keywords: giovanni alfonso borelli,galileo galilei,galileo s heritage,republic of letters,scientific correspondences,public sphere,digital humanities,data driven historical analysis,data visualization
EMPAPOSTDOCS-II MSCA COFUND International, interdisciplinary, inter-sectoral PostDoc Fellowship Programme at Empa (EMPAPOSTDOCS-II)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Switzerland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-05-01
End date: 2022-11-30
Duration (months): 67.0
Total project cost (EUR): 7080000.0
EU funding (EUR): 3540000.0
Participants: 1
Project status: CLOSED

After successfully applying for a first postdoctoral fellowship programme in 2010, Empa has decided to create a second fellowship programme: It will allow 50 experienced researchers from all over the world to create a research project and get the opportunity to work on their own research idea at one of the 30 research laboratories of Empa, in cooperation with a senior scientist of Empa of his/her choice. The training and mentoring scheme will ensure that the fellows not only enhance their scientific experience but also acquire key long-life skills making them “contributing players” of the research community and society in general. As an interdisciplinary research institution within the Swiss ETH Domain, Empa, the Swiss Federal Laboratories for Materials Science and Technology, conducts cutting-edge materials and technology research. Empa’s activities focus on meeting the requirements of industry and the needs of society, and thus link applications-oriented research to the practical implementation of new ideas in the areas of nanostructured, “smart” materials and surfaces, environmental, energy and sustainable building technologies as well as biotechnology and medical technology. Empa’s five research focal areas and three locations offer a large degree of freedom of research topic and destination for the applicants. The close cooperation of Empa with its industry partners ensures that the fellows will gain sufficient cross-sectorial experiences while being at Empa. Empa’s world-leading expertise in the various research fields and the close ties with industry offers a good balance of academic/research and industrial experience. The applicants will be evaluated by an internal and external selection committee of peer-reviewers according to strict selection criteria focusing on the applicants’ professional, personal, social and leadership skills and his or her research potential. The fellows will be offered an Empa contract of two years.

Keywords: international,interdisciplinary,inter sectoral,postdoctorand,training,mobility
Reliable AI for Marine Robotics (REMARO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Germany,Norway,Netherlands,Denmark,Portugal,Portugal,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-12-01
End date: 2025-04-30
Duration (months): 53.0
Total project cost (EUR): 4076959.2
EU funding (EUR): 4076959.2
Participants: 11
Project status: SIGNED

The underwater industry is an important part of European economy, including wind energy, oil&gas, food, pharma, mining, and bio- and geo- science. A responsible and environmentally-friendly growth of this economy calls for automation of monitoring to prevent unexpected energy blackouts, oil&gas spills, and pollution from food, pharma, and mining. This in turn requires development of reliable AI for underwater robotics. The REMARO ETN brings together recognized robotics AI, software reliability, and safety experts. It shall train 15 ESRs able to realize the vision of reliable autonomy for underwater applications. REMARO attacks one of the most pressing problems of modern computing, the safety of AI, in the well defined context of submarine robotics. The REMARO ESRs will develop the first ever underwater robotics AI methods with quantified reliability, correctness specs, models, tests, and analysis & verification methods. REMARO rests on two founding principles: 1. The submarine robot autonomy requires a comprehensive hybrid deliberative architecture, 2. Safety and reliability must be co-designed simultaneously with cognition, not separately, as an afterthought. The expertise of the consortium allows to deliver a world-class interdisciplinary training-by-research program in computer vision and machine learning, reasoning and planning, model-driven-engineering, testing, verification, and model-checking. The REMARO program includes almost 40 days of intense activities, 3 cross-sector cross-discipline Challenge Camps, and 37 secondments, including 20 at industrial labs. The network will communicate results to two large research communities and to industry via European platforms and its own Industry Follow Group. The training material will be published in the REMARO book and the REMARO online Learning Hub. The software and data will be licensed for open use to accelerate research and maximize the long-lasting impact on European underwater robotics industry.

Keywords: autonomy,safety,underwater robotics,robotics ai,safety of ai,vision,localization,navigation,planning,testing,model checking,verification,probabilistic programming,model driven engineering
Thermal imaging to assess individual physiological state in wild animals (THERMALIMAGING STATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-02-01
End date: 2025-02-18
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: SIGNED

Understanding variation in ability to survive and pass on genes (fitness) is central to evolutionary biology and conservation ecology. Fitness differences are largely explained by physiological state, as physiological processes are dynamically adjusted to maximise fitness in response to environmental variation. However, assessing physiological state in wild animals is usually invasive, requiring trapping and handling. As well as raising ethical concerns, such techniques interrupt natural behaviour, can cause bias toward trappable individuals, and may alter subsequent performance. Welfare limits on repeated invasive sampling also restrict tracking of responses over time. Previously, I provided proof of concept for an innovative alternative approach to overcome these issues – non-invasive thermal imaging of body surface temperature. I showed body surface temperature reflects two physiological processes highly relevant to fitness – acute stress and maintenance of energy reserves. But, the mechanisms underlying these relationships remain unclear, calling for rigorous experimental exploration to build the foundations needed for this method to be applied in research and conservation. Hence, the aim of this proposal is to develop thermal imaging as a powerful new tool to advance understanding of the links between individual state and fitness in natural environments. An initial visit to the world leading wild-vertebrate stress lab (Tufts University, US) will be used to perform detailed physiological validations in captivity. Methods established in the US will then be field-trialled in the EU, guided by the expertise of internationally recognised ecophysiologists at the University of Groningen and Max Planck Institute for Ornithology, ensuring in-depth synthesis of results. Combined, this work will place me at the forefront of the exciting, transformative use of thermal imaging as a novel tool for studying how wild animals cope with changing environments.

Keywords: fight or flight response,acute stress,energy reserves,body surface temperature,stress induced hyperthermia,infrared thermal imaging
Promoting Multi-Stakeholder Contributions to International Cooperation on Sustainable Solutions for Aquaculture Development in South-East Asia (EURASTIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Coordination and support actions
Countries involved: Ireland,Belgium,Belgium,Malaysia,Belgium,Norway,Belgium,Belgium,Netherlands,United Kingdom,Viet Nam
Call: Reinforcing international cooperation on sustainable aquaculture production with countries from South-East Asia (H2020-SFS-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 1998779.0
EU funding (EUR): 1998779.0
Participants: 12
Project status: CLOSED

EURASTIP will evaluate and prepare for the launch of an international multi-stakeholder platform (MSP), so as to provide a new mechanism to create and reinforce international cooperation on sustainable aquaculture between Europe and South-East Asia and will focus on actions that will provide mutual benefit to both regions. EURASTIP, headed by the European Aquaculture Technology and Innovation Platform (EATiP) will create and support 3 National Pilot multi-stakeholder Platforms (NPPs) in major aquaculture producing countries (Thailand, Vietnam and Bangladesh) and develop road-map models for others in the region, providing the foundation for an international MSP. It will create, develop and reinforce the networking needed for the promotion of B2B partnerships, using European and SE Asian networks, realising international brokerage events and promoting cooperation. EURASTIP will identify and address common standards for aquaculture site planning, animal health, food product safety and farm governance, supporting sustainable aquaculture development. Focus is given to reinforcing professional skills and competences in industry and research, using European and SE Asian education networks and industrial apprenticeship opportunities. The NPPs will develop vision documents, strategic research and innovation agendas (SRIAs), priorities and proposed actions; these will feed into EURASTIP impact measurement and including influence on national and regional policies. Attention is given to widespread dissemination actions, promoting EURASTIP in SE Asia and in Europe, encouraging a strong legacy position. URASTIP will provide recommendations and a plan for the establishment of an international MSP, covering its scope and operation further to the project timeline, leading to reinforced long-term international cooperation efforts and opportunities.

Keywords: aquaculture,sustainability,international cooperation,multi stakeholder,capacity building,innovation,efficiency,training,impact,food security
Realising an Applied Gaming Eco-system (RAGE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Germany,Italy,Bulgaria,Romania,France,France,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom
Call: Advanced digital gaming/gamification technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 8999942.5
EU funding (EUR): 8999942.5
Participants: 21
Project status: CLOSED

The EU based industry for non-leisure games (applied games) is an emerging business. As such, it´s still fragmented and needs critical mass to compete globally. Nevertheless its growth potential is widely recognised and even suggested to exceed the growth potential of the leisure games market. RAGE will help to seize these opportunities by making available 1) an interoperable set of advanced technology assets tuned to applied gaming 2) proven practices of using asset-based applied games in various real-world contexts, 3) centralised access to a wide range of applied gaming software modules, services and resources, 4) an online social space (the RAGE Ecosystem) that arranges and facilitates collaboration that underlie progress and innovation, 5) workshops and online training opportunities for both developers and educators, 6) assets-based business cases that support the games industry at seizing new business opportunities, and 7) a business model and launch plan for exploiting the RAGE Ecosystem beyond the project´s duration. Intermediary organisations and education providers anticipate a wider exploitation of RAGE results among their end-users, which add up to over 1 million, and through disseminating RAGE in their partner networks. The game companies in RAGE anticipate adding RAGE-based products to their portfolio, in order to improve their competitive advantage by opening a new product line for applied games and developing new revenue streams. Actual deployment of RAGE results will generate direct impact on the competitive positioning of the few thousand of European SMEs in the Applied Games market. Impacts from RAGE will be visible in terms of fulfilling new client needs by quicker and more challenging methods of skills acquisition, enabling new business models based on the usage of the assets repository and the Ecosystem, and in the strengthening collaboration across the entire Applied Games value chain.

Keywords: games industry,innovation,social skills,employability,gaming assets,interoperability
Quantum Hydrodynamics: Applications to nanoplasmonics (QHYDRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Recent years have witnessed a remarkable surge in interest for the electronic properties of new materials, particularly when excited by electromagnetic radiation. This is a very vast domain of research that encompasses all sorts of nano-objects (metallic films and nanoparticles, carbon nanotubes, semiconductor quantum dots,…), new materials like graphene, as well as metamaterials whose structure can be engineered so as to display some particular optical properties. In this project, we will focus our attention on metallic nano-objects and the composite metamaterials that can be constructed out of them, such as networks of interacting nanoparticles. Standard methods to study the electron response – such as the time-dependent density functional theory or Hartree-Fock equations – are computationally very costly in terms of run time and memory storage. On the other hand, recent approaches rely on much simpler methods based on improvements of the classical Mie theory. Here, we propose to develop and implement a set of quantum hydrodynamic (QHD) models that are sufficiently simple to be run on standard computers (desktop PC or small university cluster), but contain enough physics to study the electron response beyond the Mie model – in particular nonlinear, nonlocal, and quantum effects. The combination of flexibility and accuracy of QHD models makes them an ideal tool to investigate many open problems in the emerging field of nanoplasmonics. Using this approach, several configurations of nano-objects will be studied, including dimers and trimers of metallic nanoparticles and nanorods, metal-dielectric multilayers, nanoparticles in the vicinity of a thin metal film, and arrays of nanoparticles interacting via the dipole force.

Keywords: nanoparticles,plasmonics,quantum fluids,ultrafast electron dynamics