Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Plasma membrane probes for photo-controlled release of signaling molecules (MemCage)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The cell plasma membrane (PM) of eukaryotic cells is a highly dynamic structure, which plays important role in diverse biological processes such as cellular uptake, neural communication, muscle contraction, and cell trafficking and signaling. The PMs are also responsible for communication between cells, especially between neurons. In particular, the exocytosis process leads to liberation of neurotransmitters and neuromodulators. On the other hand, it is a platform for receptors that convert the recognition of neuroactive molecules into ion flux and/or action potential. Therefore, to modulate and monitor the activity of neurons, an attractive approach is to design molecular tools that target cell PMs. In this project, we will combine PM-targeting anchors with photoactive fluorescent cages capable to photo-release signaling molecules. The obtained chemical tools (MemCages) will be applied for 1) imaging the neuronal organization and 2) photo-controlled activation of neurons and brain of mice by photo-uncaging of signaling molecules close to PM. The work is composed of 3 steps. First is synthesis of MemCages for dopamine and glutamate and their validation in solvents and model lipid membranes. Second is application of MemCages in cellular systems, which includes imaging and photo-stimulation of model cancer cell lines and neurons. The first step will be in vivo validation of MemCages, which will be done during the secondment. The applicant and the host laboratory plan extensive two-way knowledge transfer: the applicant will gain knowledge and expertise in membrane probe design, bioimaging in model membranes, cells and animals, whereas he will provide his expertise on design and characterization of molecular photocages for signaling molecules. The successful utility of the developed chemical tools could open new avenues for the biologists and neuroscientists working in the field of cell signaling, neuroscience and diagnosis and prevention of neurological disorders.

Keywords: fluorescent cages,membrane probes,signaling molecules,microscopy,photorelease,neuronal signaling
M80 - an hybrid-electric regional commercial aviation Aircraft (Maeve 01)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3570000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: CLOSED

Sustainable aviation is important for the EU. Denmark and Sweden have set a target to achieve 100% fossil-free domestic flights by 2030. Given that developing a new aircraft typically takes 8-10 years, it is imperative to commence work immediately if the EU intends to meet its environmental and sustainability objectives, including zero-emission aviation. Funded by the European Investment Council, the Maeve M80 project is dedicated to the creation and commercialization of the world’s first hybrid-electric aircraft for the commercial aviation market, capable of decarbonizing existing flight routes in the regional aviation segment. It’s Maeve’s mission to reduce more than 50 MT of CO2 from commercial routes before 2040. M80 can accommodate 80 passengers and cover distances of up to 1.482 km, and is aimed for entry-into-service in 2031.

Keywords: elica,commuter aircraft,electric aircraft,green aviation,passenger aircraft
Habenula molecular and functional Organization in models of Pathological Emotional States (HOPES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Emotions guide humans and animals in the selection of behavioral strategies to optimize outcomes and promote well-being. Repeated or unexpected strong negative stimuli such as stressors impair the processing of emotions and lead to the development of mood disorders such as depression and anxiety. Understanding how individuals control their emotions and cope with stressful events has become a major clinical challenge for the development of new treatments. This project aims to define the circuit mechanisms that control emotional regulation. I will focus on a brain region key in emotional regulation, namely the lateral habenula (LHb). Over the past decades, clinical and preclinical studies have identified the LHb as a major hub in the regulation of negative emotions and in the induction of mood disorders. Recent studies have highlighted that lateral hypothalamic (LHA) excitatory inputs to the LHb drive negative emotions (i.e., aversion) and may play a role in depression. However, how the LHb integrates diverse types of inputs to promote negative emotions remains unknown. The main hypothesis of the project is that the complex regulation of emotions is defined by a discrete organization of inputs to LHb that underlies maladaptive circuit-specific dysfunction in models of stress. I will investigate here the molecular and functional properties of the LHb neurons based on their discrete inputs from the LHA. I will use a multidisciplinary approach combining cutting-edge spatial transcriptomics, neuronal tracing and optogenetics to define for the first time the role of the molecularly-defined discrete LHA-LHb pathways in normal and disease-related behaviours. This project will provide key insights about the regulation of mood by the lateral habenula and how the inputs from the lateral hypothalamus are key in the pathophysiology of depression and anxiety disorders.

Keywords: emotional processing,habenula,hypothalamus,neuronal diversity,mood disorders
NEXTMOL - A virtual lab for safe and sustainable chemicals (NEXTMOL)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Our society and economy are profoundly influenced by chemicals. Chemicals have helped to raise our standard of living, but new challenges steadily emerge and novel chemicals are demanded, representing a key element of the commercial success of tomorrow's industrial products and competitiveness of industry. Up to now, chemicals have been designed and characterized mainly using experimental techniques. However, with today’s increased competition, the experimental trial-and-error approach has become too slow and inefficient. Chemical companies need solutions that reduce the time and cost required to develop new chemicals. Bytelab Solutions develops NEXTMOL (www.nextmol.com), a Software-as-a-Service platform for chemistry R&D. It provides molecular modelling and artificial intelligence tools to speed up the development of safe and sustainable chemicals. NEXTMOL shortens the path to chemical innovation accelerating the development by 10x over traditional approaches based exclusively on the laboratory. Our greatest challenge as a company is to shift from organic growth to scalable growth. Initial sales and grants have allowed us to grow organically, develop our product to an early-adopters beta release, and gain the first customers. However, it is now the time to aim big and build a scalable company able to provide innovative, reliable and secure deep tech solutions to many customers in the chemical industry. This project will prepare us to raise private investment in Q3 2022.

Keywords: digital randd,b2b,deep tech,industry 4 0,saas,cloud computing,high performance computing,safe and sustainable chemicals,specialty chemicals,molecular modeling,artificial intelligence
Reimagining monetary policy as a federal project (FEDMONEY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499199.32
EU funding (EUR): 1499199.0
Participants: 2
Project status: SIGNED

Monetary policy suffers from a “one size fits all” problem. Central banks typically determine monetary policy by setting a headline interest rate uniformly across their jurisdiction. Yet, in large jurisdictions, the optimal monetary policy on average tends to be suboptimal for economically heterogeneous regions. Outside the realm of monetary policy, a solution to this type of governance problem is widely accepted: federalism. But the state of the art has not analyzed federalism as a paradigm of monetary governance. This is curious especially because it is not uncommon for central banks to be structured institutionally according to federalist principles: split into a central headquarters and decentralized branches. Yet even then monetary policy is determined centrally and uniformly across central bank jurisdictions. FEDMONEY’s research hypothesis is that it is desirable to federalize monetary policy by taking advantage of federal central banking structures to modulate monetary policy differently across economically heterogeneous regions. Its central aim is to develop a systematic legal and economic analysis of monetary federalism, which we currently lack. FEDMONEY seeks to verify its research hypothesis by writing the untold legal history of monetary federalism in the United States and Europe. It will contextualize that history in light of constitutional theories of federalism in both jurisdictions, as well as the intellectual history of economic thought. The project is groundbreaking in that it opens up new horizons for research in law, economics and beyond, and creates a powerful new tool for central banks to shape economic growth and development. FEDMONEY is urgent because central banks rediscovered monetary federalism in their responses to the past decade of economic crisis, but lack a theoretical framework grounded in law and economics to assess its costs and benefits. Absent such a framework, interest in monetary federalism is likely to fade soon.

Keywords: monetary policy,federalism
Promoting co-designed sustainable health interventions with young changemakers for reduced risk of non-communicable diseases (NCDs) in urban Burkina Faso, Kenya and Tanzania (Changemaker)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Sweden,United States,Kenya,Finland,Burkina Faso,Tanzania, United Republic of,Germany
Call: Interventions in city environments to reduce risk of non-communicable disease (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3998161.25
EU funding (EUR): 3998161.25
Participants: 13
Project status: SIGNED

Changemaker objective: To implement & evaluate a sustainable health intervention program on health, nutrition, & environmental outcomes for the primary prevention of adolescent obesity & related non-communicable diseases (NCDs) together with adolescents in three rapidly urbanizing cities in Burkina Faso, Kenya, Tanzania. Background: There is an increasing epidemic of adolescent obesity that can contribute to adult obesity, morbidity & NCDs in a broader sense. Sustainable health interventions in urban low- and middle-income countries are critical in addressing lifestyle factors that contribute to obesity, diabetes & hypertension in later life, such as unhealthy dietary habits, inactivity & sedentary behaviors while shaping urban environments. Considering obesity is a complex issue that is influenced by wide range of interconnected factors, such as policy, environment, social, economic, cultural, behavioral, commercial, & biological determinants, a whole-systems approach that converges multiple sectors (i.e., health, education, environment, and agriculture) and stakeholders (i.e., adolescents, caregivers, staff, local government, communities, policymakers & implementers) are needed for obesity prevention in LMICs. Our strategy: Four evidence-based strategies, which will be adapted to context through a co-design process: 1) urban farming in schools with satellite farms and organic waste composting, 2) sustainable health modules for classrooms, 3) linking to healthcare workers through health talks using motivational interviewing techniques and 4) WHO Best Buys: Mass media campaign. Our evaluation: 3 cluster-RCTs in secondary schools, within the framework of urban Health & Demographic Surveillance Systems, implementation, process evaluation & cost-effective evaluation. Our expected results: Evidence of how to implement and scale a sustainable health intervention. Estimate a mean difference in BMI of 0.175 which could lead to reduction of 5% in the prevalence of obesity.
Training Wind Energy Experts on Digitalisation (TWEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Denmark,Norway,Netherlands,Germany,Portugal,Greece,Switzerland,United Kingdom,Belgium
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3132212.91
EU funding (EUR): 2923581.6
Participants: 18
Project status: SIGNED

Training Wind Energy Experts on Digitalisation (TWEED) Doctoral Network (DN) aims to train the next generation of excellent researchers equipped with a full set of technical and complementary skills to develop high-impact careers in wind energy digitalization. This goal will be achieved through an outstanding research-for-innovation programme, and a unique training programme that combines hands-on research training, interactive schools and hackathons, innovation management and placements with non-academic partner organizations An integrated research program will be carried out alongside the development of a Virtual Wind Energy Data Science Hub that facilitates a virtual research environment to foster collaboration, data sharing and testing of innovative solutions seeking drastic cost-of-energy reductions. The network will provide an interdisciplinary and inter-sectoral context to foster creativity in transforming technological challenges into data science problems that can be solved to develop prototypes for commercial exploitation. Researchers will be trained in business innovation to extend their focus beyond the academic context to be able to identify added-value products or services through customer discovery and guidance from established researchers and entrepreneurs. As a result, a research-for-innovation mindset will be developed to provide enhanced career perspectives to the fellows, equipped with a complete set of thematic, technological and innovation skills. Moreover, TWEED network will accomplish the foundation of Wind Energy Data Science (WEDS) as a new research discipline across the EAWE network to raise awareness, exploit synergies, and motivate future career choices. The potential of data-intensive science as a new paradigm will allow reducing the cost of energy by as much as 13% during the project lifetime and 50% by 2050 by intelligent solutions not accessible to traditional wind energy specialists.

Keywords: wind energy,data science,digitalization,energy internet,innovation,machine learnig,artificial intelligence,big data,meteorology
Transparent conductive oxide nanocrYstalline films for eleCtronics and optoelectronics via low-cost solution prOcessing (TCOtronics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

TCOtronics project aims at developing and bridging to the market a revolutionary concept of a low-cost solution process to fabricate transparent conductive oxide-based films optimized for optical, electronic and optoelectronic applications. We will fabricate multilayer photonic structures, for filters and mirrors, and transparent electrodes for visible solar cells and transparent electronic circuits. We will employ only Earth-abundant elements. We will scale-up the fabrication process developing and optimizing nanocrystal inks for printers. Transparent conducting films (TCFs) are very important for many different applications including touch screens, portable and flexible electronics, optics, multifunctional windows or solar cells. The TCF market is anticipated to reach USD 10.2 Billion by 2028 with a CAGR growth of 9.8% in terms of value from 2020 to 2028. It is dominated by transparent conducting oxide (TCOs) thin films for many decades now, as TCOs carefully balance electrical conductivity controlled by doping with other elements and optical transmittance. Nevertheless, the ceramic nature of TCO films make them often brittle and fragile, and also their deposition conditions are not compatible with the printing of electronic components on flexible substrates. This will ultimately affect the flexible and portable electronics sector and hence alternative fabrication protocols are desired. Also the optical properties of thin film oxides are important. In particular the near and mid infrared wavelength range is becoming increasingly important for wireless communication, biophotonics, sensing, or heat shielding. Hence, novel more cost-effective processing techniques are required that replace the current deposition methods of oxides in general and TCOs in particular and that result in similar optical and electric quality as the industrially well-established deposition techniques finding application as transparent electrodes and photonic structures.
Engineered Exosomes for Stimuli-responsive Image-guided Drug delivery for Cancer Theranostic applications. (TheranoXome)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

The primary objective of this project is to engineer a non-immunogenic cell-membrane mimicking drug delivery vehicle for remote-controlled precision drug delivery. This will be achieved by encapsulating stimuli-responsive & contrast enhancing nanoparticles and drug cargo into endogenous exosomes to develop a therapeutic-cum-diagnostic exosomal system viz; TheranoXome for image-guided stimuli-responsive drug delivery. Such bio-mimetic TheranoXomes if realized will have wide applicability as a universal drug-delivery agent. The project entails three steps: (1) Synthesizing TheranoXomes by template assisted loading of chemotherapeutic drugs, light responsive thermoplasmonic gold nanorods and magnetic nanoparticles as magnetic resonance imaging agents into exosomes; (2) (Bio-)Physicochemical characterization of TheranoXomes including colloidal properties, biomimetics, immuno-compatibility, light-triggered drug release, magnetism (imaging and magnetic guided enrichment) and in vitro studies (2D and 3D cell cultures); (3) Application of TheranoXomes in vivo in a breast tumor bearing mice model. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of TheranoXome is to provide me with a solid foundation in biomaterials, which will support my future career endeavours, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research centre at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by one secondment (6 months) focused on in vivo (drug delivery and imaging) studies (Health Research Institute of Santiago de Compostela - IDIS).

Keywords: colloid chemistry theranostics,in vivo bio and medical imaging,nano materials production and properties stem cell biology