Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Wireless UltraSound Powered Diamond based Neural Stimulators (SonoNeuroS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-11
End date: 2025-01-10
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

The neurodegenerative diseases and neurological disordered in Central nervous system (CNS) are increasingly recognised as major causes of death and disability in the world, which eventually treatment cost is about €800 billion per year. The main reason behind the non-existence of efficient treatment is that unlike young neurons, mature neurons from the CNS lose the ability to regenerate their axons after injury. To understand the detailed mechanisms, remain not only unknown in Neuroscience but represents also a major challenge for public health and society. Neuro-stimulation is technique that stimulate the activity of neuron and provides solutions to fill the knowledge gap. Current neuro-stimulation techniques somehow limited to large neuron brain areas, rely on wires to powering system, and suffers from rejection by body inflammable. The emerging wireless and battery-free technologies based on ultrasonic communication allows to remove electrode connections to external source. The overall goal of SonoNeuroS project is to develop proof of concept of a fully wireless ultrasound-based powering of electrical stimulation technique with in sub-mm range with diamond electrode materials. This research proposal aims to develop and validate the proposed stimulators for sufficient amount fully wireless power communication, battery free with shrinking size for implantable within 100 µm. We will use diamond due to interesting properties for chronic implantation is its high resistance to corrosion, very good biocompatibility. In this idea combining ultrasound powering with Piezoelectric Micro-Machined Ultrasonic Transducer (p-MUT) technology to diamond electrodes, in order to reduce the size results at a smaller scale axial resolution of single neuron activity. After develop wireless neural stimulators, we will have used it to study the effect of electrical stimulation on output of retinal ganglion cells (RGCs), which provides new way towards to visual prostheses.

Keywords: ultrasound,electrical stimulation,instrumentation,micro fabrication,neuro stimulation
Unlocking the Power of Medical Images for Surgeons (AVATAR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-06-01
End date: 2025-08-31
Duration (months): 27.0
Total project cost (EUR): 3560375.0
EU funding (EUR): 2492262.0
Participants: 1
Project status: SIGNED

Surgeons depend on medical images to make difficult decisions. MRIs and CT-scans that are difficult to interpret can lead to unnecessary surgeries, more invasive operations and slower recoveries. The AVATAR surgery solution is a groundbreaking productivity tool for surgeons and medical specialists. It is the first photorealistic XR viewer of 3D medical images, based on innovative machine learning algorithms and data visualization techniques, with the express objective of enhancing medical decision making. Through high-fidelity local or Cloud-based render streaming, AVATAR will be the first solution to meet surgeon expectations for seamless preoperative and intraoperative data integration. Our Clinical Applications will assist surgeons in planning and implementing specific procedures. For hospitals struggling to manage growing demand for surgery, AVATAR promises to provide valuable productivity gains without investing in new equipment or personnel.

Keywords: digital services,surgery,business model innovation,virtual reality,3d images
The emerging role of TARGET OF RAPAMYCIN in regulating the shade-induced pathogen susceptibility in plants (The disease facTOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

In close proximity, plants can sense each other’s presence via a decrease in the red to far-red light ratio (low R:FR) in the nearby surroundings. Low R:FR perception by phytochrome photoreceptors triggers strong and rapid elongation growth allowing plants to grow taller than their neighbors and reach better lit areas. This process, known as shade avoidance is mostly orchestrated by the growth hormone auxin. However, although low R:FR promotes elongation growth, it compromises plant defense against pathogens by dampening defense hormone signaling; a phenomenon referred to as shade-induced susceptibility. Furthermore, I recently found that plants exposed to low R:FR conditions accumulate glucose, which accelerates pathogen development in plants tissue. Yet, the involvement of primary metabolism in regulating the shade-induced susceptibility remains to be explored. In eukaryotes, the TARGET OF RAPAMYCIN (TOR) kinase is a master growth regulator integrating the cell energy and carbohydrate status to regulate growth and defense responses. In plants, TOR activity is promoted by auxin and glucose, both strongly induced by low R:FR. Interestingly, I also found TOR gene expression to be induced by low R:FR in a recent RNA-seq study. In this project, I will study if and how low R:FR regulates TOR signaling to promote growth at the expense of defence. I will use genetic and chemical approaches to (I) identify the spatiotemporal dynamics of TOR gene expression and TOR protein activity in response to shade in the model plant Arabidopsis thaliana, (II) identify the dependency of shade-induced auxin levels and sugar accumulation on TOR dynamics and (III) characterize potential links between TOR signaling and defense hormone signaling. The gained insights will be instrumental for understanding how plants use shade signals to balance growth and defense responses and will help to engineer new pathogen-resilient crop varieties, which can be grown optimally at high densities.

Keywords: target of rapamycin shade avoidance auxin signalling soluble sugars plant defence plant growth
Neuroprosthetic Modulation of Large-Scale Brain Networks for Treating Memory Disorders (MEMOPROSTHETICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

Cognitive deficits caused by ageing, neurodegenerative diseases or brain injury represent a major public health issue. They are associated with a disruption of neural oscillations in large-scale brain networks, which cannot be restored using current treatments. Here, I propose a new neuromodulation framework for manipulating neural oscillations across large-scale brain networks to improve learning and memory. Specifically, I will create a large-scale neuroprosthesis of the hippocampus-prefrontal cortex circuit, which will simultaneously record and stimulate electrically key areas of the episodic memory network. I hypothesize that spatially, spectrally and temporally specific stimulation protocols within this network will enhance the functional interactions between hippocampus and prefrontal cortex, and will improve learning and memory. This conceptual approach will be evaluated in non-human primates trained on a visuospatial learning task. First, I will combine an electrocorticographic grid over the prefrontal cortex with depth macroelectrodes in the hippocampus and entorhinal cortex to create a novel large-scale brain implant. I will use this device to investigate the neural signatures of successful vs failed trials. Next, I will optimize electrical stimulation protocols that replicate successful neural signatures, and will test whether they improve memory in healthy animals. Third, I will induce temporary cognitive deficits in the animals using a cholinergic antagonist, and will assess the effects of stimulation in this pharmacological model of dementia. Finally, I will evaluate the chronic feasibility of this approach by translating these concepts into a fully implantable and wireless platform suited for future clinical applications. MEMOPROSTHETICS will lead to the development of neuroprostheses that palliate memory deficits in preclinical models of ageing and dementia, and will open new avenues for studying and treating a wide range of cognitive impairments.

Keywords: neurostimulation,neuroprosthetics,brain machine interfaces,memory,non human primates
TURBULENCE, PEBBLES AND PLANETESIMALS : THE ORIGIN OF MINOR BODIES IN THE SOLAR SYSTEM (TiPPi)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

The Minor Bodies of the Solar System, Asteroids, Trojans, Comets and Kuiper Belt Objects are left over planetary building bricks called planetesimals once abundant in the solar nebula. Via collisions and accretion of large grains, aka Pebbles, they grew into planets. The efficiency of Planetesimals formation via a gravitational collapse of Pebble clouds and the characteristics of the forming planetesimals are determined by the size distribution and local concentration of the largest grains, both being regulated by gas turbulence. But turbulence itself is dependent on the abundance of small grains, by regulating the ionisation level and the radiative cooling process. In this project we will develop radically new types of numerical experiments of three stages of planetesimal formation, with the goal of a self-consistent turbulence and pebble size distribution: 1. Development of tools to measure the transport, diffusion, and collisions of dust grains for arbitrary MHD or Radiation Hydro disk simulations to derive via an Coagulation Code and Machine Learning Technique a consistent particle size distribution for consistent opacities and ionisation rates to feed back into the turbulence simulation. 2. Implementation of a tree-solver for the gravitational attraction among pebbles in self-consistent turbulence simulations to identify the properties of pebble clouds that can undergo gravitational collapse. 3. Integration of an implicit solver for our Lagrangian Particle scheme to model the collapse of pebble clouds, while not only deriving a mass function and multiplicity, but with a model for elasticity and porosity analyse the spin, shape, and compression for the forming planetesimals, comets and asteroids. In close collaboration with our scientific community we will calibrate our turbulence models and the planetesimal formation process on the observation of disks around young stars as well as observational and laboratory data on Minor Bodies in the Solar System.

Keywords: asteroids,comets,kuiper belt objects,pebbles and planetesimals,turbulence,numerical simulations,magneto and radiation hydro dynamics,n body simulations,lagrangian methods,machine learning
Transformative Living Labs for Soil Health: Advancing Regenerative and Conservation Agriculture Across Europe (TRAILS4SOIL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Spain,Portugal,Ukraine,Slovenia,Germany,Romania,United Kingdom,Austria,Italy,Switzerland,Belgium,Moldova, Republic of
Call: Co-creating solutions for soil health in Living Labs (HORIZON-MISS-2024-SOIL-01, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 11765988.75
EU funding (EUR): 11745988.75
Participants: 22
Project status: SIGNED

TRAILS4SOIL will co-create 5 Living Labs (LLs) across 9 European countries, encompassing 100 experimentation sites including 11 lighthouses. This initiative aims to address the urgent need for sustainable soil management in Europe by fostering stakeholder collaboration and overcoming barriers to the widespread implementation of better soil management farming systems. The project will develop pathways for implementing economic, policy, technical, and social measures to drive the transition towards a resilient and sustainable agri-food system grounded on healthy soils. Through innovative and participatory research in diverse agroecosystems, TRAILS4SOIL will demonstrate the potential of Regenerative and Conservation Agriculture Practices (ReCAP) to achieve the objectives of the EU Soil Mission. By actively engaging local communities in a multi-actor approach process TRAILS4SOIL will provide tailored scientific knowledge and technical guidelines, that will inspire and empower farmers and other stakeholders to promote sustainable land management improving soil health. The interdisciplinary and transdisciplinary expertise of the consortium, which includes 22 partners among universities, research centres and farmer associations, will ensure the achievement of the proposed objective. TRAILS4SOIL will advance the understanding of soil health by integrating cutting-edge technologies to facilitate the widespread adoption of sustainable soil management solutions.

Keywords: soil conservation minimum soil disturbance soil cover crop rotations crop livestock integration living soils biodiversity improvement
Cytostatic compound fate and transport in soil and groundwater (CyTiS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

CyTiS will examine the fate and transport of cytostatic compounds in soil and groundwater from waste infiltration sites to drinking water resources. Cytostatic compounds are emerging contaminants classified as carcinogenic and genotoxic by the EU. They have been identified in surface, ground, and drinking water, but there is no published research on their fate and transport in soils and groundwater. Cytostatic compounds may enter soil via septic systems and waste infiltration beds and then enter groundwater. Since about 75% of Europeans rely on groundwater for drinking water, it is important to know the capacity of soil to retard or degrade cytostatic compounds, and to understand transport characteristics of these compounds through groundwater to drinking water. CyTiS will elucidate how cytostatic compounds move from sources of environmental input to sources of environmental impact. This project will use soil column experiments and stirred batch reactors in a state-of-the-art soil column laboratory to develop sorption, biodegradation, and transport models. Effect-based screening and metagenomics will be used to characterize the effect of cytostatic compounds on microbial communities and to identify resistant organisms that may be useful for bioremediation. Chemical analysis will be performed using the most advanced LC-MS method. The physiochemical data generated will inform risk assessments on how cytostatic compounds are likely to migrate if introduced into soils, will enable improved design of infiltration beds and leaching fields and may identify organisms key for bioremediation. The project results will serve as a launchpad for the researcher in the field of emerging contaminants and groundwater resources within Europe.

Keywords: cytostatic drugs,groundwater transport,emerging contaminants
RObust simulation Systems exploiting AI based turbulence models and hight-fidelity algorithmS (ROSAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: France,Italy,Germany,Spain,Belgium,Sweden,United Kingdom
Call: Competitiveness and digital transformation in aviation – advancing further capabilities, digital approach to design (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 4630603.46
EU funding (EUR): 4630603.46
Participants: 14
Project status: SIGNED

To meet global EU objectives related to aeronautical industry competitiveness and climate-neutrality, highly advanced design technologies are needed to allow fast and reliable evaluations of innovative configurations. ROSAS aims at exploiting Artificial Intelligence (AI)/Machine Learning (ML), coupled with recent advances in Computational Fluid Dynamics (CFD) technology and the underlying turbulence modelling to reduce expensive and time-consuming physical testing and drastically accelerate the whole design optimization process. Partners will build a methodology based on defining test cases, targeting the key flow problems encountered in industrial applications and reproducing them precisely in a controlled environment via Hi-Fi simulations or experiments. The results will be gathered in a database which will serve the development and testing of novel data-driven methodologies (AI-ML) and mesh generation algorithms. Improved turbulence models, including multi-fidelity surrogate models with advanced verification and validation process, will be created with modifications based on new theoretical considerations and AI-ML-based modifications, resulting in hybridization of specific turbulence models. In addition, Application Challenge test cases will be defined in relation to Clean Aviation applications to match closely industrial configurations of interest, to assess and demonstrate the new methodologies developed in the project. ROSAS brings together 14 partners from 8 EU countries and 1 from UK. The consortium comprises 4 leading research organizations, 5 leading university groups, a Super-Computing Centre, and 3 major aeronautical industries. All partners will bring their innovativeness, infrastructures, and long experience in design and aerodynamics modelling, ensuring industrial exploitation of results by exploring new aircraft and engine concepts more effectively. 1 SME will bring experience in project management, communication, and exploitation.

Keywords: artificial intelligence,computational fluid dynamics,turbulence modelling,turbulent flow,high fidelity,surrogate models,green aviation,hybridization
Real-time investigation of alpha-synuclein liquid-liquid phase separation by time-resolved small-angle X-ray scattering and computer simulations (ELSa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

Parkinson's disease (PD) affects 10 million people worldwide and is characterized by the abnormal accumulation of protein aggregates in neuronal cells. Such aggregates are mainly composed of an intrinsically disordered protein called alpha-synuclein (α-syn). Recent evidence suggests that the nucleation event driving α-syn aggregation might be initiated by liquid-liquid phase separation (LLPS). Due to a lack of techniques able to look at the early-stage LLPS the link between α-syn aggregation and LLPS is missing. Current strategies mainly focus on temporal scales where LLPS is already in place (seconds, minutes, hours) and hence there is the need to access the temporal scale of sub-second to shed light on this mechanism. The goal of Elsα (Early-stage LLPS of α-syn) is to elucidate the molecular mechanisms underlying α-syn LLPS and disentangle the contributions at play. To this purpose, I will use an innovative multi-disciplinary approach that combines a cutting-edge time-resolved small-angle X-ray scattering technique with computer simulations. The first enables real-time investigation of LLPS formation with an unprecedented temporal resolution of up to milliseconds. The second will complement the experimental outcomes with a molecular view of the phenomena. By integrating experimental and computational methods, I will identify key factors initiating α-syn LLPS, disentangle their contributions, construct comprehensive phase diagrams for α-syn under various conditions, and eventually unravel the early-stage molecular events in LLPS formation. This research promises to significantly advance our understanding of PD pathogenesis, potentially leading to novel early-phase screening methods and more effective therapeutic strategies for PD neurodegenerative disorder. Further, It will lead to high-impact publications that will increase my visibility in the scientific community boosting my career on the path to becoming a young group leader.

Keywords: proteins,molecular simulations,small angle x ray scattering,microfluidic,coarse grained models