Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the infectome of Candida albicans (CAINFECTOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 166982.27
EU funding (EUR): 166982.27
Participants: 1
Project status: CLOSED

The opportunistic human fungal pathogen, Candida albicans causes a wide range of serious disease manifestations, especially in individuals with an impaired immune system. The ability of C. albicans to successfully infect almost every anatomical niche of the human host is both a serious medical problem and an interesting biological property. It is known from in vitro transcriptional profiling that the organism rapidly alters gene expression in response to changing environments; however, very little is known of gene expression patterns in vivo. In addition, a significant proportion of C. albicans genes expressed during infection have no known function. This study will address these two problems in the following ways. Firstly, the transcriptional profile of C. albicans interaction with the host during three distinct models of infection (oral, liver and blood) will be analysed to determine whether C. albicans responds using general transcriptional mechanisms during infection or whether responses are specific depending on the anatomical niche. This transcriptional analysis will then form the basis of a systematic disruption strategy to elucidate the function and role of unknown function genes. Relevant deletion mutants will be generated using a rapid PCR based method and tested for host-interaction using established models of infection. This characterisation will elucidate the function of unknown function genes during infection and describe de novo properties of C. albicans biology. Furthermore, by testing mutants in more than one model of infection it will be shown whether a gene upregulated specifically during one type of infection has significance in another.

Keywords: candida albicans,infection biology,transcriptional profiling,alternative infection models
FLUID-STRUCTURE INTERACTIONS IN OFFSHORE ENGINEERING (OFFSHORE FSI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-08-01
End date: 2010-11-30
Duration (months): 28.0
Total project cost (EUR): 179860.2
EU funding (EUR): 179860.2
Participants: 1
Project status: CLOSED

Fluid-structure interaction (FSI) is a multidisciplinary field which involves fluid mechanics, structural mechanics and vibrations, complex techniques for instrumentation and data analysis and numerical methods applied to computational fluid and solid mechanics. Two main FSI topics will be investigated during the course of the fellowship: Wave impact mechanics and vortex-induced vibrations (VIV) on offshore structures. There is a need for data collection regarding deformation of bluff body shapes under wave impacts, for different wave heights, lengths, steepness, and the geometry and immersion of the impacted structures. Surface vessels, floating production systems, and new offshore energy generation devices (wind turbines, wave energy devices,…) are the main applications. On the other hand, there are still major concerns about the VIV of flexible structures: sheared flows, the effect of surface waves and motions on the structural response, array configurations and the effect of developed wakes on downstream structures, are problems that definitely need further study. The same facilities and measurement techniques can be used to study such engineering problems. This fellowship provides the perfect opportunity to master all these techniques and to investigate at the same time, the physics governing that phenomena, with the final objective of being able to understand, characterize, control, suppress or minimize VIV and wave impact loading on marine structures. It is expected that the results of this research will have major impact on design tools and guidelines of marine structures, contributing to increase their safety and reliability. Laboratory experiments are planned for the outgoing phase at Prof. Gharib’s group in the Graduate Aeronautical Laboratories at the CalTech. More experiments in combination with computations are planned for the re-integration phase, at the Dept. of Mechanical Engineering of Universitat Rovira i Virgili.

Keywords: fluid-structure interactions,flow-induced vibrations,vortex-induced vibrations,wake-induced vibrations,wave impact,wave slap,bluff bodies,vortex wake,offshore structures,flexible risers
Europe against Cancer: Optimisation of the Use of Registries for Scientific Excellence in research (EUROCOURSE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Partnership: EUROCOURSE (ERA-NET)
Countries involved: Romania,Estonia,Belgium,Denmark,Finland,Italy,Sweden,United Kingdom,Ireland,Spain,Sweden,Netherlands,Austria,Iceland
Call:  (FP7-ERANET-2007-RTD, 2007)
Start date: 2009-04-01
End date: 2012-09-30
Duration (months): 42.0
Total project cost (EUR): 2200443.71
EU funding (EUR): 1999408.0
Participants: 15
Project status: CLOSED

EUROCOURSE will tackle fragmentation in the funding and usage of cancer registries in Europe. It will do so by exploring ways to link and integrate national/regional programmes aimed at supporting cancer registries and research carried out using registry data. At the same time EUROCOURSE is seeking to optimize the use of cancer registration data for the amelioration of cancer control and the strengthening of population-based cancer research in Europe. EUROCOURSE will therefore adopt a two-pronged approach. Firstly, funding organisations, will exchange information, best practice and technical know-how in order to harmonise the way cancer registries are funded and organised. Secondly, cancer registries will be provided with the infrastructure necessary for harmonizing their data through exchange of technical know-how, best practices and the development of recommendations. Additionally, the process of data collection will be streamlined in order to provide comparable, accurate and timely statistics at the European level. EUROCOURSE’s consortium represents a significant coverage of the European Cancer Registry landscape. Given the large number of cancer registries and funding organizations supporting the registry network however, the project envisages a flexible structure, including the introduction of new parties during its lifetime. This will be done essentially through the working groups that are firmly embedded in the workpackages. EUROCOURSE’s inclusive approach will culminate in the FIRST EUROPEAN CANCER SUMMIT, which will aim to bring for the first time all stakeholders in the cancer control community in Europe – including funders, researchers and other interested parties – around one table to sketch out the future of European Cancer Registration in Cancer Control. EUROCOURSE will therefore expand as a direct consequence of the planned activities and therefore will have a major and sustained impact on cancer control and research in Europe.

Keywords: cancer,cancer registries,harmonization of funding,optimization of registry data usage
Wealth and poverty in Shakespeare and Dickens (WEALTHANDPOVERTYKP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 161225.98
EU funding (EUR): 161225.98
Participants: 1
Project status: CLOSED

The research aims to analyse the representation of money and poverty in England in the period of the first and second Poor Laws. It will focus on two specific moments in the history of the representation of money and poverty and the policies relative to the latter: the literary representation of wealth and poverty in 16th –17th century and 19th century England in the work of William Shakespeare and Charles Dickens and the corresponding policies regarding poverty (the first and second Poor Laws). The research objective is to explore the relation between the representation of money and the concept of poverty in these two crucial moments for the legislation on poverty, in order to extrapolate a theoretical model for the analysis of the relation between the representation of poverty and knowledge production. This project will allow the researcher to consolidate and expand her area of expertise. In previous work the researcher has focused on 13th century French-Italian, 17th century Holland and 19th and 20th century German philosophical production regarding the concept of money and the concept of poverty in relation to knowledge. In this project the researcher will analyse 16th–17th century and 19th century England, with a focus on the literary representation of money and poverty and the governmental techniques of management of poverty issues. This research will contribute to the formation of a complete framework for the conceptualisation of money and poverty in Europe from the Middle Ages to the present day, a framework which she will use to address the critical issue of the representation of wealth and poverty in current debates in European Philosophy, thus strengthening her position in the European scientific community. A dissemination strategy has been devised to ensure that findings will lead to new publications, new resources for research, team work and for the production of thought.

Keywords: poverty wealth money value representation knowledge production shakespeare dickens foucault poor laws techniques of power governmental management force epistemological break europe
The Limits of Peaceful Co-existence: Jewish-Arab Relations, Urban Space and State Violence in Palestinian-Israeli Mixed Towns, 1882 to the Present (EMT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-01
End date: 2011-08-31
Duration (months): 32.0
Total project cost (EUR): 163304.41
EU funding (EUR): 163304.41
Participants: 1
Project status: CLOSED

As part of a larger project on ethnic relations in Mediterranean Cities, this research examines how urban space, violent conflict and national identities have been both represented and produced in ethnically mixed cities in Israel/Palestine. Against the background of a century-long conflict between the Jewish and Palestinian national movements, this project studies the relations between opposing “projects of nativization” and community building efforts in a contested urban setting. While most scholars conceptualize these collective identities as separate projects – defined only by the exclusion and negation of the other – I focus instead on the relations of mutual determination between local communities often rendered invisible in Palestinian-Israeli studies. Thus, the study posits mixed towns as a challenge to the ethno-nationalist guiding principles of the Israeli state, which ultimately fails to maintain segregated and ethnically stable spaces. This failure results in the parallel existence of heteronomous spaces in these cities – operating through multiple, often contradictory logics of space, class, nation and governance. Analyzed relationally, these spaces produce a peculiar form of quotidian social relations between Arabs and Jews as well as new forms of local identities that challenge both Palestinian and Jewish nationalisms. Focusing on cities like Jaffa, Haifa, Acre, Lydda and Ramla, I historicize the problematic place they occupy in the Israeli and Palestinian popular, political and sociological imagination. Through ethnographic, statistical and historical analysis I show how Jewish and Palestinian citizens, implicated in relations of interdependence, strive to define their respective collective identity. These processes serve as a lens through which the research engages a wider set of questions in political sociology and urban anthropology regarding ethnicity, citizenship, and identity-making as embedded in practices of “making place.”

Keywords: ethnically mixed towns,palestine,israel,state violence,ethnic conflict,bi-nationalism,coexistence,conflict resolution,urban space,nationalism,mediterranean cities.
REGULATION OF GLUCOSE-STIMULATED SECRETORY VESICLE MOBILISATION IN PANCREATIC BETA-CELLS (INSULIN SECRETION.)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-11-30
Duration (months): 30.0
Total project cost (EUR): 168256.91
EU funding (EUR): 168256.91
Participants: 1
Project status: CLOSED

During meals our bodies break food down into glucose which then moves from the bloodstream into cells to be utilised. This process requires insulin production by the pancreatic beta-cells. Impaired function of these cells leads to inadequate insulin output and elevated blood glucose level. The failure of beta-cells is the main reason for the development of diabetes which affects 22.5 million people in the European Region. We are interested in the mechanisms by which beta-cells respond to changes in blood glucose concentration with insulin release. In beta-cells insulin is carried in vesicles, called large dense core vesicles (LDCVs). The mechanics of the transport and fusion of LDCVs are one of the steps that go wrong in type 2 diabetes. Our recent studies have revealed that LDCVs move along their tracks driven by motor proteins such as conventional kinesin. This project aims to understand how the activity of these proteins is regulated by glucose. The spatial-temporal relationship between LDCVs and conventional kinesin movements in response to nutrients will be studied using real time imaging. The role of glucose-stimulated protein kinases and phosphatases in controlling LDCV and kinesin movements and their impact on the association of kinesin with vesicles will be investigated. Novel beta-cell specific kinesin interacting proteins, that link kinesin to LDCVs, will be identified together with the signalling pathway(s) involved in the mobilisation of LDCVs. This multidisciplinary project will reveal fundamental information on the molecular mechanism and regulation of glucose-stimulated LDCV mobilisation. Stimulation of this process may provide novel strategies for the treatment of type 2 diabetes.

Keywords: biological sciences,cell biology,medical sciences,insulin secretion,endocrine function
Modelling Ultra Wide Band Radio Propagation in Human Body (HUMANITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-03-15
End date: 2010-03-14
Duration (months): 12.0
Total project cost (EUR): 85829.48
EU funding (EUR): 85829.48
Participants: 1
Project status: CLOSED

Ultra Wide Band (UWB) Wireless bio-medical sensors is a promising new application made possible by recent advances in ultra low power technology. Each sensor measures parameters of interest and sends the data in short bursts to a central device. In developing these sensors, detailed knowledge of the communication channel is essential. Moreover, UWB has a wide variety of applications in medical imaging. The aim of this work is to study the interaction of the UWB signals with tissue of human body and develop appropriate channel modelling tools to be used either for communications or for UWB medical imaging. In particular, propagation characteristics of the different tissue will be investigated, with the purpose of providing an insight into precise relation of these quantities to frequency. Beneficiaries will include, at the beginning, the wireless communication and the bioengineering communities, but the real aim is that the results of the proposed research can contribute to the evolution of communication systems which can dramatically change the future of healthcare with many benefits for patients.

Keywords: technological sciences,communication engineering,biomedical engineering,electronic engineering
Pyramidal neuron polarity decisions during migration and axonal outgrowth in the developing mammalian cerebral cortex (NEURONAL POLARITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 228652.58
EU funding (EUR): 228652.58
Participants: 1
Project status: CLOSED

During embryonic brain development, pyramidal projection neurons are born in the ventricular zone and migrate radially towards the upper part of the cortex to form the cortical plate. These neurons also have to develop dendrites and axons in order to make connections. Several brain diseases and mental illness derive from defects in neuronal migration and positioning or in axon-target interactions for the establishment of synaptic circuitry. Studies with cultured pyramidal neurons have shown that similar polarity decisions, and many of the same proteins, specify the direction of migration and the orientation of axon outgrowth. However, in vivo, in developing brain, it appears that axons start growing before the completion of neuronal migration, and the axon is always positioned at the opposite side to the migration front. An important open question is to understand how the neuron is able to distinguish spatially and temporally these two opposite polarity signals by using the same polarity proteins in vivo. The results suggest that the situation in a polarized epithelium in vivo is different to that observed in vitro. Indeed, in non-mammalian organism such as the fly, some polarity proteins seem to be dispensable for polarized neuronal migration. We propose to determine the position of the apical pole of a pyramidal neuron during its migration and differentiation in vivo during mouse brain development. We will identify the timing of possible switches in cell polarity relative to the timing of axon emergence, and identify molecules involved in these decisions. Importantly, our studies will be done in vivo and in a living brain slice culture assay.

Keywords: developmental neurobiology,tissue culture,neuronal migration,axonal specification,cell polarity
As seen from North-East Asia: Potential and limits of the EU as a strategic actor (EU-NORTHEASTASIA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 24.0
Total project cost (EUR): 138981.03
EU funding (EUR): 138981.03
Participants: 1
Project status: CLOSED

This research project explores the potential, and the limits, of the EU as a strategic actor in North-East Asia. It does so by focusing on a comparative analysis between EU motivations and aspirations towards China on space and defence matters and the perceptions and reactions of Chinese on the one hand and of Japanese, Taiwanese, South Korean and American policy makers on the other hand. The project is informed by and relates to the literatures on European foreign policy and the international politics of North-East Asia. It is innovative as it links these two broad areas of research. The study engages with the major viewpoints in these literatures and uses the method of structured, focused comparison for the purposes of examining both intended and inadvertent consequences of European foreign policy towards a country (China) for the surrounding regional system (North-East Asia) and the US’ strategic interests in the area. This would lend itself to a wider analysis of the potential, and of the limits, of European foreign policy and of the EU as a novel strategic actor. The research findings would provide both empirical knowledge on the determinants for the promotion of EU space and defence interests in China and on the perceptions and reactions of North-East Asian and American policy makers as well as theoretical insights into EU strategic actorness. The project would contribute to revisit current views in the literatures on European foreign policy and the international politics of North-East Asia by adding the analysis and discussion of the EU as a novel strategic actor in the region. The research findings would also be of use for EU policy-makers in developing a more precise set of policies tailored to China and North-East Asia in order to better promote EU interests and values in a part of the world that has become increasingly important for the socio-economic welfare of the EU.