Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Location, location, location: the (re-)positioning of regulatory elements in the mammalian genome. (RE_LOCATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2493875.0
EU funding (EUR): 2493875.0
Participants: 1
Project status: SIGNED

In mammalian genomes, the enhancers (E) that control a promoter (P) are often scattered over tens to hundreds of kb, and frequently interdigitate with Es that control other nearby Ps. How such apparently haphazard linear arrangements can result in specific gene regulation is a major puzzle. Three main constraints are thought to be involved. First, biochemical compatibility of Es and Ps may ensure that not all Ps respond equally strongly to a given E. Second, chromatin loops may either facilitate or curb particular E-P interactions. Third, Es and Ps are controlled by the local landscape of chromatin modifications. Much is still to be learned about these constraints and their interplay. To unravel the logic of this linear arrangement of Ps and Es, it is necessary to systematically alter the positions of Es, Ps, and elements that control looping. So far, no efficient method has been available for this purpose. We propose to develop and apply RElocate, a scalable, broadly applicable technology to transplant selected DNA elements to hundreds of alternative positions within a ~2 Mb region, and track the functional consequences. We will employ RElocate in combination with a high-throughput combinatorial reporter assay to systematically study how biochemical compatibility may dictate how Es "choose" and activate the correct target P(s). Furthermore, we will adapt RElocate to precisely map how loop extrusion shapes E-P interactions, by insertion of hundreds of unidirectional “road blocks” throughout a locus. Finally, we will use the method to fine-map the repressive/activating chromatin landscape of selected regions at high resolution, and elucidate how Es and Ps may respond differently when inserted throughout this landscape. This work will reveal how the ordering and spacing of regulatory elements along the genome contributes to optimal gene regulation, and will yield a powerful perturbation tool with many applications in genome biology and human genetics.

Keywords: regulatory elements method development enhancer promoter interactions linear genome organization chromatin looping large scale perturbations
Towards Green Hydrogen by Layered Metal Halide Perovskite Heterostructures (TOGETHER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-16
End date: 2025-01-15
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Green hydrogen is feedstock, fuel, energy carrier, and storage at the same time, and one of the important cornerstones to decarbonize industrial and economic sectors on the European continent. The proposed action ‘Towards Green Hydrogen by Layered Metal Halide Perovskite Heterostructures - TOGETHER’ will deliver a highly tunable material platform by integrating lateral heterostructures in two-dimensional layered metal halide perovskites (2DLP) to overcome the high exciton binding energy and ultimately enable long-distance charge separation for photocatalytic generation of green hydrogen. The structures developed in TOGETHER will provide a spatially confined directional flow of electrons to the edge of the semiconducting layer in 2DLPs, where they can be extracted by protons to form hydrogen. The unique flexibility of the materials platform architecture will result in a large degree of freedom to tune each step in the photocatalytic cycle to increase the solar-to-fuel conversion efficiency. The formation of lateral heterostructures in 2DLPs will be achieved through tailored consecutive ion exchange, which is a powerful tool to manipulate the composition while maintaining the crystal structure, size, and shape of the parent object. TOGETHER is a highly interdisciplinary effort that builds on cutting-edge research in material science with chemistry, physics, and engineering.

Keywords: perovskites
Collaborative Actions to Bring Novel Biofuels Thermochemical Routes into Industrial Scale (BioTheRoS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Spain,Germany,Austria
Call: Best international practice for scaling up sustainable biofuels (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2998625.0
EU funding (EUR): 2998625.0
Participants: 6
Project status: SIGNED

BioTheRoS Project aims at developing a holistic methodology that will boost the scale-up of sustainable biofuels via thermochemical conversion technologies. These are pyrolysis upgrading through hydrodeoxygenation and Fischer-Tropsch synthesis from biomass gasification. The project will bring together key actors at a both European and International level, such as technological and social experts, renewable energy-oriented associations along with industrial experts that will bring and exchange their knowledge in order to reach the project targets. Within the project, several non-food biomass feedstock will be analyzed and optimized across their entire value chain. Barriers linked with the selected feedstocks supply and pretreatment will be identified. Furthermore, AI-based predictive models will be developed, in order to be adapted to the scale-up cases. Then, the most promising biomass feedstock will be tested experimentally in the studied thermochemical reactors. At this point of the project, technical constraints and opportunities for the scale-up of the sustainable biofuels thermochemical processes will be identified. Possible synergies of blending pyrolysis oil and gasification based advanced biofuels will be investigated by a potential end-user (petroleum company). The selected data will be used as an input for advanced modelling tools, including process modelling, CFD tools and LCA/LCC/sLCA tools results of which will feed a multi-criteria analysis to derive generalized up-scaling rules and guidelines of the produced biofuels. The engagement of several stakeholders in the planning of the scaling-up of sustainable biofuels production will be crucial at this point, since they will review the project results and assess if a biofuel production technology can be delivered from the lab/pilot to a larger-scale, by taking into account operational difficulties, plant cost and plant capacity limitations (technological barriers).

Keywords: thermochemical processes,sustainability,scale up,gasification,pyrolysis
European Advanced Reusable Satellite (EARS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Italy,Lithuania,Belgium,Spain
Call: New space transportation solutions and services (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 1296158.75
EU funding (EUR): 1296157.0
Participants: 6
Project status: CLOSED

This program proposes to design and build a low-cost spacecraft capable of supporting a variety of small experiments for orbital periods potentially longer than a year. The vehicle is to be designed to operate and return to Earth autonomously, to be reusable with minimal refurbishment, and to be compatible with common launch vehicles secondary payload attachments. The spacecraft is based on a current microsatellite platform with the addition of a heat shield, a powerful propulsion system and a recover system. The spacecraft is launched in LEO and perform its mission, which can be IOD/IOV, microgravity scientific experiments, or commercial activities like microgravity manufacturing. Thanks to its own propulsion system the spacecraft can re-position itself and perform a controlled reentry. After reentry and when the vehicle slows to the designated Mach number, a drogue parachute will be deployed which will decelerate the vehicle to a condition permitting deployment of the steerable gliding parachute. Terminal descent on the main parachute is controlled so that the vehicle soft-lands at a designated landing site. The reusability feature has four main advantages: - Recover of the payload for usage/inspection/analysis - Possibility to reuse the satellite for different missions - Possibility to abort a mission without loss of the payload - Limited pollution, debris mitigation both on ground and in orbit This platform follows the call indications as it deals with re-entry technologies, green propulsion, advanced GNC. Marketing surveys have indicated that there is considerable user interest for such a platform.

Keywords: satellite,reusability,spacecraft
Diagnostic model and assay for personalized vaccine (DiMoVac)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Seasonal influenza poses a major global public health challenge, causing 3-5 million cases of severe illness and 290,000-650,000 deaths annually. Influenza vaccines are crucial for preventing illness, reducing severity of infection, and limiting virus transmission; however, their efficacy varies across populations due to factors such as immune status and pre-existing comorbidities. Immunocompromised patients (e.g. rheumatoid arthritis, HIV or organ transplant recipients) are particularly vulnerable to influenza and consequent complications include hospitalization and death, as their immune systems often fail to mount adequate responses to standard vaccines. Leveraging data from our previous ERC-St grant-funded studies, we analyzed the serological and multi-omics profiles of various cohorts across 5 time points over 4 influenza seasons. This analysis, covering multiple virus strains, identified robust molecular biomarkers linked to vaccine responses, which were validated through wet-lab experiments. Machine learning models based on pre-vaccination biomarkers were able to predict vaccine response in independent samples. Building on these findings, we propose to develop a diagnostic assay to measure these biomarkers and apply our established prediction model to stratify patients based on their responsiveness to the influenza vaccine. Samples from various patient cohorts, provided by our collaboration partners, will be used for verification and validation. Once validated, these biomarkers will be integrated into an innovative, fast, and reliable diagnostic test to predict vaccine responsiveness, through collaboration of an experienced industrial partner. Additionally, our team will create a user-interface app to translate biomarker measurements into diagnostic outcome. By enabling personalized vaccine strategies particularly for patients, this project has the potential to significantly improve influenza vaccine efficacy, reduce disease burden and ultimately save lives.
EXPANDing the value of Extracellular Vesicles as carriers of biomarker and therapy in precision healthcare (EXPAND-EV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Serbia,Germany,Greece,Croatia,Spain,Slovenia
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1473314.29
EU funding (EUR): 1357000.0
Participants: 13
Project status: SIGNED

Extracellular vesicles (EVs) have been identified as important signaling mediators in a myriad of physiological and pathological processes. There is an emerging effort to advance the exploitation of EVs in precision healthcare, with special emphasis on drug delivery and liquid biopsy. However, the current technology readiness level in the field and lack of standardized methodology guidelines are limiting the exploitation of EVs, so a significant leap toward the establishment of novel tools has to be made. EXPAND-EV’s main goal is to provide a unique solution for advancing the current diagnostic and therapeutic potential of EVs by developing and implementing versatile, scalable, cost-effective and reproducible purification systems, based on single-domain antibody affinity technology for high-performance scalable EVs capture, in two parallel lines of research: (I) the system will be validated in clinical laboratory settings on breast (BC), liver (HC) and lung cancer (LC) by analyzing differential expression of multi -omics (proteomic, glycomic and transcriptomic) EVs-related features, with the goal to develop a panel of biomarkers that would contribute in timely diagnostics, enable a convenient and non-invasive prognosis assessment and tailored therapy. (II) development of GMP-compliant protocol for producing edible plant EVs as carriers of therapeutic siRNA molecules. Their safety profile and therapeutic potential will be tested on BC, HC and LC cell lines and mouse models. By establishing a consortium composed of excellent research groups and SMEs across Europe, EXPAND-EV will bring forth the needed paradigm shift in EVs research by solving the major bottleneck issue in the field. Creating a simple, robust, cheap, scalable and reproducible EVs purification system will provide much-needed technology for application of EVs in personalized medicine, leading the transition of EVs use from a promising laboratory concept to a feasible and applicable theranostic agent.

Keywords: extracellular vesicles nanoantibodies breast cancer liver cancer lumg cancer liquid biopsy drug delivery
In silico modelling of cold atmospheric pressure plasma on cholangiocarcinoma (InSilicoCAPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-02
End date: 2028-01-01
Duration (months): 24.0
Total project cost (EUR): 190219.44
EU funding (EUR): 190219.44
Participants: 3
Project status: SIGNED

Cholangiocarcinoma (CCA) is an aggressive cancer with a poor prognosis, requiring complete resection for a chance at a cure. Cold atmospheric pressure plasma (CAPP) has emerged as a promising, localized treatment that minimizes damage to healthy tissue, unlike chemo- and radiotherapy. However, the interaction between CAPP and tumors remains poorly understood, particularly in controlling electric fields and reactive species during treatment. Current plasma flow models are largely 1D, 2D, or axisymmetric, while 3D in silico models can better capture tumor heterogeneity and physiological conditions. This project aims to develop a novel, open-source, full 3D multiphysics and multiscale in silico modeling platform to optimize CAPP treatment for CCA. The framework will enhance our understanding of plasma-tumor interactions, enabling precise control of treatment parameters and maximizing therapeutic efficacy while minimizing damage to surrounding healthy tissue.

Keywords: computational fluid dynamics in silico cold atmospheric pressure plasma optimization methods cholangiocarcinoma
Market analysis of the hydrogen sector for anion exchange membrane electrolysis and fuel cells (MarketHy)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Ireland,Slovenia
Call: EIC Booster grant for EIC Pathfinder and EIC Transition grants (HORIZON-EIC-2024-BOOSTER-IBA-01, 2024)
Start date: 2024-12-01
End date: 2025-11-30
Duration (months): 12.0
Total project cost (EUR): 60714.29
EU funding (EUR): 50000.0
Participants: 2
Project status: SIGNED

The hydrogen market is growing exponentially with the increasing needs to displace fossil fuels from the energy, transport and manufacturing sectors. With the demanding targets set by the EU, innovative technologies for hydrogen production and use need to be accelerated. Anion exchange membrane systems offers a more economic alternative compared to the more established proton exchange membranes, by avoiding the use of perfluorinated substances, as well as working in environments that allow the utilisation of low or platinum group metal (PGM)-free electrocatalysts. In addition, saline electrolytes can serve as models for more stringent wastewater or seawater that can be used directly in electrolysers. However, further innovation is required on stable components operating under these conditions. The technical solutions to these problems are the main goals of the EIC funded projects ANEMEL and ENABLER, but a dedicated work looking at the exploitation was not considered in the individual projects. Therefore, this projects aims at developing a common strategy for innovation in the hydrogen market sector. Relevant research questions to answer are the understanding on the market size for anion exchange membrane water electrolysers and fuel cells, the value chain, the techno-economic analysis of different resources for the manufacturing of the devices, and the identification of the barriers to commercialisation. Overall, the expected outcome is a roadmap that serves as an initial exploitation strategy for the innovations developed as part of the ANEMEL and ENABLER projects.

Keywords: hydrogen water electrolysis,fuel cells,anion exchange membranes,low and pgm free electrocatalysts
Multi-modal, configurable optical lab-on-chip platform for low-cost multipurpose diagnostics & monitoring (MultiLab)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Cyprus,Greece,Germany,Belgium,Spain,Austria,Ireland,Switzerland,France
Call: Pervasive photonics - multi-technology integration for digital infrastructure, sensors and internet of things (Photonics partnership)(RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4856697.5
EU funding (EUR): 4856697.5
Participants: 14
Project status: SIGNED

There is an increasing need for miniaturised, multifunctional sensors providing simultaneous access to diverse chemical & biochemical information, required in various applications. Nowadays, such information, is routinely obtained by centralized laboratories and the use of analytical techniques. Although such methods will remain important when an immediate response is not necessary, easy-to-use, rapid point-of-need sensors that can be used by non-specialized personnel or even operate in a completely automated (unattended) manner could be a game-changer in a diverse range of fields such as disease management, robotics or for the early detection of environmental threats. Nanophotonic devices that precisely control light in subwavelength volumes and enhance light–matter interactions, have opened up new prospects for sensing applications, addressing the limitations of current analytical methods in terms of sensitivity, ease-of-use and miniaturization. There are, though, challenges to be overcome. MultiLab addresses these challenges by developing a highly flexible multi-sensing platform compatible with wafer scale manufacturing that will integrate multiple sensing modalities to simultaneously detect biological, chemical, microorganism and molecular targets for medical diagnostics & IoT-based environmental monitoring. The sensing modalities integrated in the MultiLab platform are a) plasmonic augmented, Arrayed Waveguide Grating sensing on a Si3N4 photonic platform for true & scalable multiplexed detection, b) mid-IR PTS employing the same SiN photonic platform for on-chip interferometric sensing by means of MZIs including also the same plasmonic devices and optical read-out as for the PA-AWG, c) graphite-based electro-chemiluminescence sensing. The system will be demonstrated in two applications: a) IoT-enabled, early warning of harmful algae blooms in fresh water sources, b) diagnosis & prognosis of fever without an apparent source.

Keywords: photonics biosensors,photothermal spectroscopy,electrogenerated chemiluminescence,plasmonic augmented arrayed waveguide grating