Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomics and Metabolomics in a Host-Microbe Symbiosis Network (SymbNET)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Switzerland,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2024-08-31
Duration (months): 44.0
Total project cost (EUR): 900000.0
EU funding (EUR): 900000.0
Participants: 5
Project status: SIGNED

Host-Microbe Symbiosis is a growing crucial axis of research in Biology, with impact in Human Health. Research in this field requires multidisciplinary highly skilled teams and collaborative research. To leverage the Host-Microbe Symbiosis research at FCG-IGC (Portugal) we will establish a European network in the use of Genomics and Metabolomics in this field. SymbNET, coordinated by FCG-IGC, will bring together the world leading research institutions EMBL (Germany), Kiel Univ. (Germany), and UNIL (Switzerland) and another local widening partner ITQB NOVA (Portugal), with whom we already collaborate locally. The network will bring together a consortium of leaders in the field that present a wide range of expertise, technological knowledge, scientific questions, and approaches in Host-Microbe Symbiosis. Therefore, SymbNET will be transformative to FCG-IGC and ITQB NOVA research and establish a center of excellence in Host-Microbe Symbiosis research in Portugal. SymbNET will promote transfer of knowledge and collaborations through programs of Researchers and Staff visit exchanges, collaborative projects, sponsoring the use of new technologies, organizing scientific meetings of the network, workshops, PhD Summer Schools, and a European meeting on Host-Microbe Symbiosis. There will be actions targeted at Early Stage Researchers to promote their research, training, mentoring, and networking, and ensuring gender equality in participation. The interaction with these leading institutions will also leverage FCG-IGC Research Management through the capacitation of the new Center for International Collaboration. SymbNET will promote a network for excellence in the field of Host-Microbe Symbiosis, capacitate the widening institutions, raise the profile and research quality of FCG-IGC, ITQB NOVA, and the other participating institutions, and establish an European consortium in this growing crucial area of research.

Keywords: host microbe interaction,microbiota,mutualism
The next generation of forest inventory (forecast)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Accurate mapping of tree species and estimation of wood volume and biomass are important assignments of any forest inventory. However, forestry operations currently rely heavily on field data as a basis for estimating its attributes. This labour-intensive approach provides limited information and has become a costly bottleneck in completing operations. Today, remote sensing data plays a key role to characterize forests. Generation of accurate models combining a huge bunch of data requires the use of advance AI techniques that provides real time information about woods and its resources. fora has pioneered high-resolution and timely forest inventory services which combine state-of-the-art remote sensing technologies and deep learning to produce operational forest inventories that help improving the efficiency of forest management activities. Whether LiDAR, RADAR, and/or optical imagery, airborne or satellite, these sensors able to cover a large area for intensive sampling without the disadvantages inherent to labour-intensive ground sampling schemes done by field crews. However, each remote sensing solution has its own pros and cons, mainly to operate as stand-alone service. FORECAST is at the forefront of how geospatial and remote-sensing data can be harnessed to optimize safety, efficiency and productivity of forest operations. Key to FORECAST innovation is the fora proprietary calibration systems based on a double application of AI algorithms. FORECAST is the solution for forest managers and wood and paper companies, reducing the field plots to a minimum, while maintaining a high quality of information about the state of the forest at the (local) scale of individual plantations. Whether an organisation is concerned with timber, access to mills, recreation or conservation, achieving long term sustainability with an optimal return is of paramount importance for the design and implementation of effective sustainable forest management plans and forest-related policie

Keywords: forest inventory,lidar,satellite images,artificial intelligence
Reconstructing the coordinated self-assembly of a bacterial nanomachine (BacNanoMachine)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1934950.0
EU funding (EUR): 1934950.0
Participants: 1
Project status: SIGNED

Life has evolved diverse protein machines and bacteria provide many fascinating examples. Despite being unicellular organisms of relatively small size, bacteria produce sophisticated nanomachines with a high degree of self-organization. The motility organelle of bacteria, the flagellum, is a prime example of complex bacterial nanomachines. Flagella are by far the most prominent extracellular structures known in bacteria and made through self-assembly of several dozen different kinds of proteins and thus represents an ideal model system to study sub-cellular compartmentalization and self-organization. The flagellum can function as a macromolecular motility machine only if its many building blocks assemble in a coordinated manner. However, previous studies have focused on phenotypic and genetic analyses, or the characterization of isolated sub-components. Crucially, how bacteria orchestrate the many different cellular processes in time and space in order to construct a functional motility organelle remains enigmatic. The present proposal constitutes a comprehensive research program with the aim to obtain a holistic understanding of the underlying principles that allow bacteria to control and coordinate the simultaneous self-assembly processes of several multi-component nanomachines within a single cell. Towards this goal, we will combine for the first time the visualization of the dynamic self-assembly of individual flagella with quantitative single-cell gene expression analyses, re-engineering of the genetic network and biophysical modeling in order to develop a biophysical model of flagella self-assembly. This novel, integrative approach will allow us to move beyond the classical, descriptive characterization of protein complexes towards an engineering-type understanding of the extraordinarily robust and coordinated assembly of a multi-component molecular machine.

Keywords: bacterial flagellum,motility,self assembly,gene regulation,protein secretion,type iii secretion system,fluorescence microscopy,time lapse microscopy,salmonella enterica
Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish (GSTHgNDD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-06-20
End date: 2020-06-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge into the behavioural genetics skills set. This project will also allow Dr. Brennan's group to integrate developmental toxicology into existing behavioural research, and will generate new collaborations.

Keywords: gene environment interactions
For a Better Tomorrow: Social Enterprises on the Move (FAB-MOVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Spain,Italy,Italy,Argentina,Indonesia,South Africa,Italy,Israel,Germany,Germany,Poland,Sweden,China,France,France,United States,Denmark,United Kingdom,Canada,Costa Rica,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1192500.0
EU funding (EUR): 1192500.0
Participants: 28
Project status: CLOSED

The project “For a Better Tomorrow: Social Enterprises on the Move (FAB-MOVE)” brings together researchers and practitioners in order to explore the question of how social enterprises can grow and flourish. These objectives will be achieved through a carefully crafted network of academic and non-academic partner organisations co-operating worldwide. Managers and practitioners of social enterprises often lack an easy access to the frontiers of science. FAB-MOVE will significantly improve the transfer of knowledge between academics and non-academics and thus increase the practical applicability of research findings. For an enduring sustainable impact, FAB-MOVE develops a teaching tool to educate (future) managers of social enterprises on how to set up their enterprise in a specific environment, how to combine business with a social goal, and how to develop strategies for growth and scaling-up. Currently there is a lack of knowledge about the influence of different social and economic environments on social enterprises. Local eco-systems and traditions have a decisive impact on the wellbeing, growth and potentials for scaling-up of social enterprises. FAB-MOVE focuses on the embeddedness of social enterprises and its impact on their evolution. It identifies crucial success factors for a sustainable development of these new and innovative organisations in an internationally comparative perspective. Thoroughly analysed case studies will serve as best practices by highlighting how social enterprises overcome crucial problems and manage to grow in different social areas and various regions around the world. In particular, the cases will shed light on how managers of social enterprises cooperate with stakeholders and how their environment composed of promoting actors and existing (political) structures meet their needs in order to improve social cohesion all over Europe.

Keywords: social enterprises,international comparison,inclusive society,innovation,eco system,stakeholder relations
Cucurbit[8]uril Assisted Supramolecular Architectures of Carbon Materials for Hydrogels, Photocatalysis and Sensing (CASACAMAhyps)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-15
End date: 2020-06-07
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Carbon Materials (CMs: graphene etc.) are known for their light-weight and, excellent mechanical, electrical and thermal properties. However, one of the main challenges for state-of-the-art CM-based composites is the mass manufacture and low-cost production of uniformly distributed composite materials under aqueous conditions to harness these properties for various applications. Moreover, the surface functionalisation of CMs is still a great challenge, attributed to their inert surface and lack of solubility in many solvents including water. Supramolecular host-guest complexation could be a useful technique to produce uniformly distributed CMs-based supramolecular architectures (SAs). Cucurbit[8]uril (CB[8]) is a macrocyclic host molecule with 8 glycoluril units yielding a barrel-like shape macrocycle. It can accommodate 2 guest molecules simultaneously, typically 1 electron-poor (1st guest) and 1 electron-rich (2nd guest), forming a heteroternary complex. CB[8] creates an aqueous dynamic supramolecular system that can help improve the water solubility of guest molecules. Thus, the overall aim of this proposal is to develop SAs based upon host-guest heteroternary complexation between CB[8], CMs and matrices. Two entirely different matrix polymers (organic) and metal NPs (mNPs: inorganic) will be considered. Three CMs will be investigated. i) 2D Graphene(GR), ii) 1D Carbon nanofibers (CNFs) and iii) 0D Carbon dots (C-Dots). Following goals of the project will be achieved in the respective work packages: 1) Surface functionalisation of guest molecules onto CMs (fCMs). 2) To obtain Dynamic Hybrid Supramolecular Hydrogels after the host-guest complexation between fCMs, CB[8] and polymers. 3) Supramolecular heteroternary complexes between fCMs, CB[8] and mNPs to form fCMs-mNPs Supraparticles, and their 4) Applications in photocatalysis and Sensing. Overall, the fundamental investigation of how fCMs will bind to CB[8] and later to polymers or mNPs will be investigated.

Keywords: cucurbit 8 urils,host guest complexations,supramolecular architectures,carbon materials,graphene,carbon dots,hydrogels,metal nanoparticles,supraparticles,photocatalysis,sers,sensing
Resilience of Soil Stoichiometry in subartic soils under Temperature-Induced Soil Carbon Losses: Where does the N go? (StoiCa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Global warming can trigger enormous releases of carbon (C) from soils, with positive feedbacks to climate change. Northern high latitude soils can constitute a major contributor to this positive feedback loop. Climate change predictions are however still largely uncertain, partly due the lack of accurate representation of vegetation and soil microbial feedbacks and C and nitrogen (N) interactions. Warming enhances microbial mineralization of soil organic matter (SOM) (i.e. soil C outputs) to a higher degree than vegetation productivity (i.e. soil C inputs), resulting in large C losses from northern soils. Pioneer results point to proportional N losses in response to warming, which may be the key to this phenomenon. This project will combine the expertise of a multidisciplinary group of leading researchers on ecosystem stoichiometry, stable N isotopic methods and applied biotechnology with the existence of unique and established research sites in geothermal systems in Iceland to reveal the fate of N lost in response to warming, and uncover the mechanisms behind observed soil C losses. StoiCa will elucidate, for first time, three key knowledge gaps: (1) the rates, forms and mechanisms of N losses from arctic soils under warming; (2) the transient- and persistent responses and the warming-induced transitions from a closed to a leaky, open N cycle; (3) the shifts towards a more symbiotic N cycle and role of thermo-adapted mycorrhiza in stimulating plant growth. This proposal directly addresses two cross-cutting priorities of sustainable development and climate action from the H2020 Work Programme. It also represents an exceptional opportunity for the candidate to acquire the essential skills that she lacks and that will convert her into a highly competitive European researcher in climate change biogeochemistry, while obtaining intersectorial capacities that will open new career avenues.

Keywords: global warming,climate change,nitrogen cycle,soil carbon,carbon cycle,vegetation allocation,biomass productivity,plant soil interactions
Restoring of SENSAtions from Lost LeGs for health And qualIty of life augmeNtation in amputees (SensAgain)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Switzerland
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2016)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 99912.5
EU funding (EUR): 99912.5
Participants: 1
Project status: CLOSED

During the FET NEBIAS we developed and clinically validated novel and effective restoration of sensory feedback from missing hand in upper-limb amputees. They felt natural sensations, used to ameliorate control and acceptance of prosthesis, and diminish phantom limb pain. The goal of SensAgain is to exploit these results commercially. In particular, we aim at verifying whether the innovation generated during NEBIAS could be used to provide valuable device for lower-limb amputees. We target them because they represent a larger population and suffer health problems related to absence of sensations from prosthesis. Indeed, because of the lack of sensory feedback from available prostheses, they suffer: falls due to unexpected perturbations, asymmetric walking and balance which induce arthritis, osteoporosis and back pain, higher power consumption (with occasional hearth failures), feeling the prosthesis as a foreign body (with consequent abandonment) and phantom pain. The first step we will perform is the validation with market stakeholders, which will enable the identification of the minimum features of a product accepted by the market, and the development of a strategic partnership with manufacturers, which will speed up the realization of a device compliant with CE standards. Then, we will define a clear market penetration strategy. Together with providing disabled persons with a unique device for rehabilitation, SensAgain will boost prosthetic adoption, with the consequent growth of the prosthetics and rehabilitation industries, which at its turn will create new jobs. Finally, by sharing the results with the members of the NEBIAS consortium, we will train academia personnel to structure their research mind-set toward the resolution of problems tailored by the market needs. On the other hand we will favor the process of creating innovation in industry, offering job positions to people with a background in research, in case of success of our translational project.

Keywords: lower limb amputees,sensory feedback restoration,technology transfer
Participatory Designing with Sound (PaDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Today’s sonic displays play a significant role in threatening the quality of our everyday lives, personal and professional. Consequently, the interest to design sound is shifting from crafting the sound towards collaboratively understanding the role of sound and its position in complex environments, such as healthcare and autonomous driving, in which humans and technology must co-exist. Accordingly, the design process requires more inclusive, human-centered and technology-driven approaches to design sonic experiences. Yet the field of industrial design lacks systematic design methods and tools to empower design teams when they collaboratively express creativity through sound and discover sound-driven engineering solutions. Thus, with the PaDS (Participatory Designing with Sound) project, I aim at advancing the knowledge on sound-driven design thinking in which sonic communication (speaking about sound and experiences, imagining and representing them) is especially required within multistakeholder design teams that consist of expert (sound) designers as well as non-experts (e.g., users, manufacturers, policy makers). The main goal of PaDS is opening sound design practices to participatory approaches, in which stakeholders are involved in the design process as partners. The core of this project is the development of methods and representational tools to empower designers and other stakeholders to collaboratively conceptualise, express, and communicate sound-driven designs. To reach its goal, the PaDS project is based on a mixture of interdisciplinary approaches, including sonic interaction design, design cognition studies, and experimental psychology: Applied research and contextual inquiry of sound issues in complex, socio-technological environments provide relevant case studies of collaborative sound design-thinking, that is investigated through protocol analysis and perceptual experiments.

Keywords: sound design,interaction design,design cognition,multimodal,multisensory,perception,soundscape,complex sonic environments,auditory display