Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A remote and price efficient tool for jaundice screening (Picterus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Worldwide, 135 million children are born each year and neonatal jaundice, a common condition caused by elevated levels of bilirubin, affects approximately 60 to 80% of newborns; 114.000 of these newborns die yearly and 63.000 children will survive with kernicterus (severe brain damage) due to undiagnosed or late detection of jaundice. Just in Europe and USA, we estimate that neonatal jaundice costs healthcare systems €1.684 million per year. Current solutions for jaundice diagnosis require expensive hospital laboratory facilities for blood testing and newborn monitoring by professional healthcare workers. Additionally, low-income countries cannot afford blood tests and longer hospital stays to detect and treat jaundice properly. To solve this problem, Picterus has created a remote, reliable and low-cost tool with an innovative Smartphone-based system to provide remote diagnosis and monitoring of neonatal jaundice. Our unique technology based in biomedical optics and photonics detects bilirubin levels by taking babies ́ skin pictures, automatically interpreting the results. Picterus can be included in the routine newborn tests at hospitals worldwide and can also be used by parents and midwives at home to monitor the baby, thus reducing healthcare system costs in three ways: reducing extra days at hospital after birth for jaundice monitoring, reducing outpatient follow-up of patients and reducing the number of cases of permanent brain damages due to failed or missing diagnosis. H2020 funding will allow us to leverage the development of Picterus and successfully commercialize it in the European market first, and worldwide afterwards.

Keywords: mhealth,mobil health,smartphone based diagnosis,image based diagnosis,jaundice diagnosis,remote diagnosis,remote monitoring,biomedical optics and photonics,artificial intelligence
Satellite-based Observation of Land Infrastructure Deformations (SOLID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: SME Instrument (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of our project is therefore to design, build and run an innovative end-to-end service for continuous and automatic GNSS deformation monitoring based on a new generation of low-cost GNSS receivers (Global Navigation Satellite System, including GPS and Galileo), prototypes of which are currently being developed by GReD and selected partners. The objective of the feasibility study is the development of a business plan to confirm the potential market and benefits, identify application fields and to estimate the investments needed for designing, building and running an operative end-to-end monitoring service. The business plan will also consider intellectual property management, sales channels to reach the market and economic metrics for the service pricing and delivering. The overall activities of the project are foreseen to be completed within 6 months.

Keywords: gnss,galileo,deformation,monitoring,receiver,service,landslide
Artificial Oxidation Enzymes for Highly Selective Waste Free Hydroxylation of Alkanes (ArtOxiZymes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

One of the major challenges facing the chemical industries is the sustainable production of chemicals from natural resources. The challenge includes making sure that chemical processes are as ‘green’ and economical as possible, and that sustainable and abundant resources are used where possible. One type of reaction that lends itself to sustainable processes is the direct functionalization of C-H to C-X (X = O, N, C) bonds, as it generates far less chemical waste and leads to tremendous reduction of energy use than methods relying on prefunctionalized materials. The objective of this project is to achieve the C1-selective hydroxylation of n-alkanes to give n-alcohols e.g. octane to octan-1-ol, using mild reaction conditions and green oxidants such as oxygen or hydrogen peroxide, which is currently an unsolved problem. Linear alcohols are of interest as they form some of the major building blocks used in the chemical industries, for example C8-C10 alcohols for the synthesis of plasticisers and detergents. We will achieve this aim by combining traditional homogenous catalysis and biocatalysis for the development of artificial metalloenzymes as catalysts, which utilise the molecular recognition concepts of nature to bind substrates selectively in protein pockets. The target substrate will thus be bound in the correct orientation enabling selective oxidation at the target position, in contrast to traditional chemocatalysts which give a highly unfavourable product distribution. This will lead to more efficient use of valuable feedstocks and large reductions in chemical waste production and energy consumption, compared to the traditional methods for forming C1-alcohols, all contributing to a green and sustainable society. The researcher will diversify her competence, build new collaborations and gain interdisciplinary mobility through this creative and highly innovative project allowing her to maximise her contribution to the knowledge-based economy and society.

Keywords: artificial metalloenzymes,oxidation catalysis,c h functionalisation
Augmented Reality and Indoor Navigation for Enhanced ASSembly (ARIESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Hardware demonstrator development and deployment on Future Industrial Human Machine Interface (HMI) and Connected factory technologies (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-09-01
End date: 2021-10-31
Duration (months): 50.0
Total project cost (EUR): 495534.5
EU funding (EUR): 495534.5
Participants: 2
Project status: CLOSED

The future of the aeronautical industry is tied inevitably to the development of enabling technologies that make it possible the coming of the Factory of the Future. Technology advances like those on Geoposition and Navigation, the Internet of Things (IoT), Virtual and Augmented reality (VR/AR), speech and handwriting recognition, biometrics, wearable technology, drones, etc. are being widely implanted in many industries. However, aircraft manufacturing has been traditionally reluctant to the introduction of technology leaps in the production process, even those considered game changers in other sectors. This is mainly due to the complexity and the strict safety assurance requirements involving the aeronautical sector but it is that here’s a tremendous bias against taking any sort of risks, and any innovation is seen as a risk in this industry. Therefore, any improvement must guarantee the highest quality and safety standards. The final assembly of an aircraft is identified as a field with a lot of room for improvement. The introduction of some of the aforementioned technologies in the modern Final Assembly Line (FAL) can definitely impact the factory’s lean manufacturing and the environmental sustainability of the whole process. Implantation of new assembly procedures can take advantage of commercially available technology, but also actual methods and procedures like the moving assembly line, visual control systems, point-of-use staging, just-in-time delivery systems, etc. can be significantly improved. The General Objective of the current proposal (ARIESS, Augmented Reality Indoor Enhanced aSSembling for factory of the future industry) is the introduction of cutting-edge Human-Machine Interfaces (HMI) and the supporting infrastructure for indoor positioning and navigation, augmented reality techniques and real-time data integration to improve the productivity, competitiveness, and sustainability of a FAL, paving the way for the modern Industry 4.0.

Keywords: future industrial human machine interface,connected factory,internet of things iot,virtual and augmented reality vr,final assembling line fal
The Role of Cortico-Hippocampal Interactions during Memory Encoding (CHIME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-09-30
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

This research proposal’s goal is to investigate the role of cortico-hippocampal interactions during the encoding and consolidation of a memory. Current memory consolidation models postulate that memory storage in our brains occurs by a dynamic process- a recent episodic experience is initially encoded in the hippocampus, and during off-line states such as sleep, the encoded memory is gradually transferred to neocortex for long-term storage. One potential neural mechanism by which this could occur is replay, a phenomenon where neural activity patterns in the hippocampus evoked by a previous experience reactivate spontaneously during non-REM sleep, leading to coordinated cortical reactivation. While previous work suggests that hippocampal replay is important for encoding new memories, how memory consolidation is accomplished through cortico-hippocampal interactions is not well understood. This research project has three major aims- 1) examine how cortical feedback influences which spatial trajectory is replayed by the hippocampus, 2) investigate how the hippocampal replay of a behavioural episode modifies cortical circuits, 3) measure the causal role of cortico-hippocampal interactions in consolidating memories. We will record ensemble activity from freely moving rats during an auditory-spatial association task and during post-behavioural sleep sessions. We will focus our ensemble recordings on two brain regions: 1) the dorsal CA1 region of the hippocampus, where the phenomenon of sleep replay has been most extensively examined, and 2) auditory cortex, a region of the brain critical for both auditory perception and long-term memory storage. This work will use behavioral and molecular-genetic techniques in combination with large-scale electrophysiological recordings, to help elucidate the role of cortico-hippocampal interactions in memory encoding and consolidation.

Keywords: hippocampus,memory consolidation,auditory cortex,replay
Zero-CO2 cement concept evaluated with novel Nuclear Magnetic Resonance (NMR) (NMRCement)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: TERMINATED

The production of cement is predicted to account for 25% of anthropogenic CO2 emissions by 2025. There is a need to produce novel reduced CO2 cement materials to reduce global carbon emissions. This project aims to characterise a novel silicate glass material for the production of reduced CO2 cement. The novel silicate glass utilises nanoscale phase separations to enhance the reactivity. The goal of this work is two fold: first, to systematically study the tuneability of the reactivity and nanoscale phase separations in the silicate glass and second, to characterise the glass and cement samples with advanced nuclear magnetic resonance (NMR) methods. First, enhanced reactivity of glasses has previously been observed but has not been systematically studied. The composition of the silicate glass will be changed to study the tuneability of the reactivity and phase separations. The studies will be conducted using standard experiments such as solid state NMR for studying the chemical bonding and scanning electron microscopy (SEM) for visualising phase separations. The results of these studies will contribute to knowledge in glass science and produce a reduced CO2 cement material. Second, the glass and cement will be studied with advanced NMR methods. NMR is a research tool that has previously proven successful in studying the pore structures of glasses and cements. This proposal will utilise breakthroughs in NMR technology, ultrafast Laplace NMR (LNMR) and hyperpolarisaton, to gain further insight into the microstructure of samples. Ultrafast LNMR enhances the time sensitivity of LNMR scans by 2-4 magnitudes and reduces scan time by 1-2 orders of magnitude. Hyperpolarisation enhances the sensitivity of NMR scans by 2-5 orders of magnitude. Together these methods will be used to enhance the time resolution and sensitivity of NMR methods. The results of these studies will produce new NMR methodology and provide novel data in glass and cement samples.

Keywords: cement,glass,hyperpolarisation
Towards the Sustainable Development of the Atlantic Ocean: Mapping and Assessing the present and future status of Atlantic marine ecosystems under the influence of climate change and exploitation (MISSION ATLANTIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Research and Innovation actions
Countries involved: Germany,Germany,South Africa,Spain,Iceland,Spain,Spain,Ireland,Ireland,Sweden,Sweden,Norway,Norway,Belgium,Belgium,France,France,United Kingdom,United Kingdom,United Kingdom,Portugal,Canada,Brazil,Denmark,United Kingdom,Portugal,Denmark
Call: All Atlantic Ocean Research Alliance Flagship (H2020-BG-2019-2, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 11564092.5
EU funding (EUR): 11501717.5
Participants: 34
Project status: SIGNED

MISSION ATLANTIC develops and systematically applies Atlantic Integrated Ecosystem Assessments (IEAs). IEAs enable identification of ecosystem components most at risk from natural hazards and the consequences of human activities. The project employs all available information on those sources, the pressures they impose and the ecosystem components are affected, to identify the most important risk factors influencing sustainable development. IEAs are developed at basin and regional scales, using a nested approach with key case study (CS) areas including sub-Arctic and Tropical regions in the Atlantic Ocean. To support IEAs we map, model and assess Atlantic Ocean ecosystems including resilience and responses to cumulative pressures. Regional indicators are provided for both pelagic and benthic components, using existing and new data from monitoring programs, including information from new glider technology. Coupled end-to-end physical-biological models are developed and validated at the basin scale to simulate ecosystem dynamics, defining new biogeographical regions and resolving connectivity between CSs. Ecosystem state indicators are then evaluated under four future climate projections of the models, to identify future risks of crossing identified tipping points into undesirable ecosystem states. In support of the Bélem Statement, the project brings together scientists, managers and stakeholders from Brazil, S.Africa and the EU as well as US & Canada. Regional stakeholder platforms are established to support the IEAs and the interactions between researchers, industries, policy makers and authorities across the Atlantic. The platforms are delivered via partners with recognized experience in “science to governance” interfacing. Training and professional development opportunities across the Atlantic are provided via mobility, PhD and MsC programmes building around IEA theory and using an adaptive e-learning platform and examples to ensure program legacy.
Multi-omics molecular treatment targets for Prostate Cancer (PCaProTreat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The PCaProTreat Project targets on improving the Prostate Cancer (PCa) management and focuses on the identification of novel therapeutic targets for patients with an advanced disease stage. It has been demonstrated that the current medical practice has led to frequent over-treatment of patients exhibiting slow growing PCa (unlikely to progress in the absence of treatment), while for metastatic castration resistant patients that immediate treatment is required, no effective strategies are available. Therefore, new therapeutic options are required for advanced PCa. To address this clinical demand, PCaProTreat is focused on the comprehensive characterisation of the molecular background of PCa progression, based on which molecularly-driven therapeutic targets can be defined. Towards that end, PCaProTreat includes: a) multi-layer analysis (different types of specimens: tissue, urine, seminal plasma) and multi-omics profiling (proteomics, peptidomics, transcriptomics), supplemented with literature-mined data, b) establishment of the PCa knowledge database, c) data integration into Systems Biology workflow to identify key-regulatory elements responsible for disease progression (best suited drug targets) and d) validation of the selected targets using immunohistochemistry. This multi-dimensional approach represents a substantial advancement over the standards currently applied in drug discovery process, allowing to overcome the challenges associated with tumour heterogeneity and thus reveal optimal drug targets. In parallel to the research activities, a multi-disciplinary and multi-sectorial training program will be implemented to increase the competitiveness of the ER within the research community, to become a recognised researcher. Activities will be carried out in the industrial sector, with Mosaiques Diagnostics a leader in clinical proteomics and Systems Medicine, being a Host institution.

Keywords: cancer,omics technologies,proteomics,drug targets,drug development
Tumor cell death supports recurrence of cancer (Cancer-Recurrence)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1564393.6
Participants: 2
Project status: CLOSED

Introduction: Current anti-cancer treatments are often inefficient, while many patients initially benefit from anti-cancer drugs eventually experience relapse of resistant tumors throughout the body. Current clinical strategies mainly aim at inducing tumor cell death, but this induction may have unintentional and unwanted side effects on surviving tumor cells. Preliminary data: We show that after chemotherapy-induced initial regression, PyMT mammary tumors reappear. During regression, we observe an increased number of cells that have undergone epithelial-mesenchymal transition (EMT) and become migratory. We show that migration can be induced upon uptake of extracellular vesicles (e.g. apoptotic bodies). Our findings suggest that EMT is induced upon chemotherapy, through e.g. EV uptake, potentially leading to migration and growth of surviving cells. Hypothesis and main aim: Based on preliminary data, we hypothesize that tumor cell death induces migration and growth of the surviving tumor cells. We aim to identify the key cell types and mechanisms that mediate this effect, and establish whether interference with these cells and mechanisms can reduce recurrence of tumors after chemotherapy. Approach: We have developed unique intravital imaging tools and genetically engineered fluorescent mice to visualize and characterize if and how dying tumor cells can affect surrounding surviving tumor and stromal cells. We will test whether dying tumor cells can influence the growth, migration, dissemination and metastasis of surviving tumor cells directly or indirectly through stromal cells. We will identify potential targets to block the influence of the dying tumor cells, and test whether this blockade inhibits the unintended side-effects of tumor cell death. Conclusion: With the studies proposed in this grant, we will gain fundamental insights on how induction of tumor cell death, the universal aim of therapy, could play a role in growth and spread of surviving tumor cells.

Keywords: intravital imaging,cancer imaging