Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the impact of vortex-induced vibrations for enhanced wind turbine safety (VIV-WISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-02-28
Duration (months): 30.0
Total project cost (EUR): 262393.2
EU funding (EUR): 262393.2
Participants: 3
Project status: SIGNED

Despite significant advancements in offshore wind turbines (OWTs), effective life cycle assessment remains a critical challenge. An emerging limiting factor in the lifespan of these structures is vortex-induced vibrations (VIV), which may occur during the installation process, before the towers are commissioned in offshore wind farms. Over several weeks, VIV can cause substantial oscillation amplitudes, potentially leading to significant fatigue damage before the OWTs are fully operational. This issue is becoming increasingly crucial as OWTs grow in size and reduce in weight. In this context, the VIV-WISE project aims to develop and verify a new multi-physics numerical framework to address this issue. This tool seeks to (1) surpass the accuracy of current state-of-the-art by integrating novel fluid-structure interaction methodologies with recent advancements in damage mechanics, specifically the Phase Field model for fracture, to provide insights into fatigue damage caused by VIV in metals - particularly cylindrical shells and welds. (2) Establish a guide for identifying cracks induced by VIV in pioneering wind tunnel experiments, and (3) assist in the OWT tower installation process, thereby preventing significant failures before operation. Hence, VIV-WISE addresses a complex, multi-disciplinary phenomenon that encompasses both solid and fluid mechanics. The proposed methodology will not only be valid for OWTs, but also for other industrial sectors where VIV-induced fatigue damage is a concern, such as chimneys, marine risers and bridges.

Keywords: fracture mechanics,vortex induced vibrations,phase field,fluid structure interaction
Indirect optical geometry measurement (InOGeM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1981875.0
EU funding (EUR): 1981875.0
Participants: 1
Project status: SIGNED

Optical metrology is driving our society forward and has strong impacts on manufacturing, mobility, medicine and fundamental science. This is highlighted by the SI revision in 2019 and the Nobel Prize winning microscopy with visible light in the nanometre range in 2014. Optical techniques allow fast and precise geometry measurements, but only if sufficient light energy is reflected from the object’s surface to the photo detection unit. For this reason, specific measurement approaches for each surface type had to be developed such as deflectometry for highly reflective surfaces. To provide one single measurement approach applicable to any surface and with the potential of sub-micrometre resolution, InOGeM will initiate a paradigm shift: instead of measuring the object’s surface, the geometry of the surrounding gas is measured. The surrounding gas is detected optically by using tiny, well-controlled, fluorescent particles or molecules, a confocal microscope and a model-based signal processing, which enables sub-micrometre resolution. This will break new grounds for assessing additively manufactured parts and lightweight components made of fibre-reinforced composites, because the indirect measurement is less sensitive regarding the varying optical properties of the measurement object’s surface and material. Furthermore, indirect optical geometry measurements are possible at strongly curved or translucent objects even through a limited access, which is currently considered impossible. Such challenging conditions occur e.g. for gears and additively manufactured parts, so that InOGeM has a large potential for low-noise gears (e-mobility) and fuel cells (hydrogen). As a result, fast geometry measurements with a today unachievable precision below classical limits are achieved in the nanometre range for a wide range of applications. By developing the framework of a new class of measuring instruments, InOGeM takes the field of optical geometry measurements to the next level.

Keywords: optical measurement system,dimensional metrology,measurement uncertainty
Unlocking the hidden role of Algae in the plant rhizoSphere (AlgaeSphere)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: TERMINATED

In the face of climate change, biodiversity loss and a rapidly growing population, global food security relies on improving agriculture production. However, it is equally crucial to limit or mitigate the environmental impact by developing sustainable and regenerative practices. Plant health strongly depends on plant-associated microbial communities, known as the microbiome, which can increase plant nutrient acquisition, tolerance to environmental stress, and resistance to diseases. Whereas most studies have focused exclusively on bacteria and, to a lesser extent, fungi, other plant-associated microbes like algae remain largely underappreciated in the plant microbiome. However, recent reports support that algae are ubiquitous in plant microbiomes and that (living) algae can improve plant fitness by promoting growth and increasing resistance against pathogens and abiotic stress. However, the underlying mechanisms of beneficial algal-plant interactions remain mostly unknown. Land plants evolved from a green algal ancestor and both, plants and algae, have co-evolved with interacting bacteria using similar mechanisms. Thus, algae, through their interactions with plant-associated bacteria, have the potential to influence the assembly and function of the microbiome itself. The AlgaeSphere project aims to uncover the overlooked potential of algal-bacterial interactions within the plant microbiome to improve plant growth in a circular bioeconomy model. By understanding the underpinnings of algal-bacterial interactions within the context of the plant microbiome, this project aims to reveal new players and emergent functions to improve the design of stable and higher-performing microbial consortia for sustainable agriculture and biotechnological applications for biofuel production and wastewater bioremediation.

Keywords: algae plant microbiome synthetic ecology synthetic microbial communities microbial consortia algae bacteria biotechnology biofertilization wastewater treatment hydrogen production
Cohort Network To be Activated Globally In Outbreaks (CONTAGIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Coordination and support actions
Countries involved: Germany,Netherlands,United States,Colombia,France,Brazil,Venezuela, Bolivarian Republic of,French Polynesia,Malaysia,Sierra Leone,United Kingdom,Guatemala,Ecuador,Peru
Call: Pandemic preparedness and response: Sustaining established coordination mechanisms for European adaptive platform trials and/or for cohort networks (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 1776008.75
EU funding (EUR): 1773508.75
Participants: 18
Project status: SIGNED

CONTAGIO is a consortium of investigators from Europe, North America, Latin America, Asia, and Africa, that aims to create coordination mechanisms to rapidly react to infectious disease (re-)emergence in low- and middle-income countries (LMICs). The Consortium builds on the experience acquired through the EC-funded projects ReCoDiD, ORCHESTRA, ZIKAlliance, and IDAMS. We believe that observational cohorts are essential instruments as they provide much needed information on the natural history of the disease, including transmission routes, vulnerability factors, the proportion of, and risk factors for, severe disease outcomes and therefore lay the ground for intervention studies. CONTAGIO will convene cohort investigators and data/specimen sharing specialists by a) generating a preparedness and interoperability platform (WP1/2); b) enabling a suite of tools and key pathways for data sharing (WP2/3); and c) developing governance for sharing of biological material in the event of emerging infections (WP4). A key step on this path is the investigation of how ongoing cohorts ‘repurpose’ their focus from one infectious disease to another in the event of epidemics (e.g. from dengue to Zika to COVID-19). The open science foreseen in CONTAGIO will create a coordination mechanism and framework for the role of sustainable cohorts in preparedness for (re-)emerging infectious diseases during interepidemic periods, which will be vital for the joint progress towards a better tackling of disease emergence aimed at the protection of citizens in LMICs, Europe and the rest of the world.

Keywords: preparedness,harmonization,data sharing,biorepository
Mechanisms of tissue size regulation in spinal cord development (REGCORD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1993094.0
EU funding (EUR): 1993094.0
Participants: 1
Project status: SIGNED

How the organs of a developing organism achieve their correct size and shape is a fundamental unresolved question in biology. Mammalian embryos possess a remarkable ability to regulate (restore) the correct size of their tissues and organs upon perturbations during early development, yet how this is achieved is unknown. Addressing this question has so far been challenging because it requires a multiscale approach that integrates precise measurements with theoretical frameworks. We are now in an excellent position to unravel the mechanisms by which the mouse spinal cord regulates its size and shape during development by building on our experience with quantitative studies in this system. We previously obtained quantitative spatiotemporal data of growth, pattern and morphogen signalling dynamics in the spinal cord. We showed that there is a critical period during which morphogen signaling is interpreted to specify cell fates, uncovered a mechanism that allows precise pattern formation, and identified a link between the growth rate and tissue anisotropy. Our expertise now enables us to address the following new questions: 1) how is size regulation in the spinal cord achieved at the tissue and cellular level; 2) what is the molecular mechanism of size regulation, in particular the role of morphogen signaling; 3) how is the regulation of spinal cord size linked to the regulation of its shape. To address these questions, we will combine precisely controlled ex vivo assays in organoids and whole embryo culture, and in vivo advanced mouse genetics and mosaic analysis. We will obtain highly resolved dynamic data and interpret it in the context of rigorous theoretical frameworks. The project will advance our understanding of the fundamental mechanisms of tissue size control and the constraints they impose in regeneration and disease. Our results will have implications for in vitro tissue engineering and research on multi-organ coordination and robustness during development.

Keywords: tissue growth neural tube morphogen gradient biophysical models of development
Setting baseline for a PCP Heightening Innovation Procurements in the European security ecosystem and Leveraging synergies through Dissemination activities for CROWD management (SHIELD4CROWD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Coordination and support actions
Countries involved: France,Italy,Poland,Spain,Slovakia,Netherlands,Greece
Call: Stronger grounds for pre-commercial procurement of innovative security technologies (HORIZON-CL3-2022-SSRI-01, 2022)
Start date: 2023-08-01
End date: 2024-07-31
Duration (months): 12.0
Total project cost (EUR): 1102328.43
EU funding (EUR): 910986.65
Participants: 14
Project status: CLOSED

SHIELD4CROWD focuses on enhancing the protection of public spaces in EU cities against security threats related to crowd management. Public spaces are indeed largely exposed to several threats like UAV and UGV attacks, CBRN attacks, cold weapons/ firearms attacks or urban riots, and gatherings are by themselves a potential target for terrorist or criminal attacks. This focus is shared, from the start, by several actors and specifically by security practitioners. 3 ministries of Interior from 3 EU countries, 1 Public Transport Operator and 2 security practitioners from Poland and Slovakia are thus involved as full partners. Many other end-users will also be involved through the User Observatory Group (UOG) and some of them have already expressed official interest for the project. SHIELD4CROWD implements a progressive and iterative process to jointly define one common challenge that can be tackled with identified candidate technology serving the basis for future PCP, for which the buyers group will be created during the project, through the continuous involvement of the UOG. First, 10 jointly defined Common Security Use Cases will fully describe the gaps between available solutions, existing processes and identified needs. A technological analysis of those needs will then be conducted by technological experts, including exploration of legal, societal, ethical, and environmental considerations, to allow the end users to converge to 3 uses cases, from which a SOTA analysis and 4 Open Market Consultations will be conducted. All the results will finally serve to the definition of the common challenge and the elaboration of the first set of Tender Documentation. SHIELD4CROWD includes a Security Advisory Board to manage the sensitive knowledge generated by its activities, and several advisors to guide the elaboration of a Common Challenge fully compliant with Europe’s privacy and data protection regulations.

Keywords: public sector innovation,demand driven innovation,security threats and vulnerabilities,crowd management
Stay home or go beyond: deciphering the mechanisms underlying ARGONAUTE1 loading and sRNA movement in plants (LoAGOding)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Small RNAs (sRNA) are essential regulators of gene expression, controlling development and preserving genome integrity, all across eukaryotic organisms. To execute their final functions, sRNA are loaded into an ARGONAUTE (AGO) protein to guide through sequence complementarity the regulation of target genes. In plants, sRNAs are divided into small interfering RNA (siRNA) and microRNA (miRNA), and both can be loaded into AGO1 for cell-autonomous action, or move out of the cell to act non-cell autonomously. This proposal outlines a series of complementary experiments to mechanistically study the loading of sRNA into AGO1 and to understand how it contributes to the intra- and inter-cellular movement of sRNA in plants. By combining cell biology, RNA biochemistry, deep-sequencing analysis, nuclear fractionation methods, micrografting and super-resolution microscopy, this project aims at: i) characterize the nuclear and cytoplasmic sRNA loading complexes (LCs), ii) decipher the connection between sRNA biogenesis and LCs and, iii) determine how sRNA loading could affect the sRNA movement. The results obtained will advance the state of the art in plants in our understanding of AGO1 loading mechanism, the execution of the AGO1 function and sRNA movement. Studying these pathways goes beyond mere mechanistic knowledge, as sRNA movement is being exploited to modulate plant and pathogen gene expression towards improving crop productivity and enhancing stress/pathogen tolerance, a booming strategy known as Spray-induced gene silencing. Altogether, this project is expected to create a wealth of original information, providing a meaningful contribution to European excellence and competitiveness in the field.

Keywords: rna silencing srna loading srna movement argonaute proteins mirna sirna arabidopsis
Womens' health tech scaleup in Europe (PSE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Norway
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

There is a gender gap in healthcare, and women’s health suffers from lack of prioritization. Preforma AS is a deep tech company wanting to close this gap and improve women's health. Our short term objective is to introduce our product in Europe, develop our platform further, and position ourselves for scaling up with Europe as our home market. Preforma AS has a female founder, and a majority of women in management. Preforma AS is founded by Maria Ræder , a researcher and gynecologist, who over a number of years has systematized best practices and developed tools to improve gynecological examination, diagnosis and treatment. In interaction with more than 40 000 patients and healthcare personnel, we've developed a dynamic medical history collector and started conceptualizing a deep tech platform for a wider range of services. Our main challenges are: Limited international network, Market acceptance, International commercialization experience, People management, Business plan and market entry strategy and Investor relations We propose a work plan with a duration of 12 months, with two work packages: (1) A business work package focusing on product, market, technology and funding, and a (2) people package focusing on talent and network. The work packages will go in parallel, and will have common administrative processes. The main participants from our company are Maria Ræder (founder and CEO) and Madeleine Andresen (CTO). Even if we've come a long way already, we are certain that the Women TechEU programme will enrich our project to include activities that gives us a better insight in the European market, a better understanding of legal and customer requirements, and also of possible competitors and partners. We also need help to improve our internal competences and enhance our network.

Keywords: women s health
Understanding and targeting pathogenic IgG4 responses (IGG4-START)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1493090.0
EU funding (EUR): 1493090.0
Participants: 1
Project status: SIGNED

The predominant autoantibody (sub)class is an important determinant in the pathophysiology of autoimmune diseases (AID). Autoantibodies can be pro-inflammatory, such as IgG1, causing disease by complement-mediated or immune cell-mediated tissue damage. In 2015 I was the first to describe a second group of AID where IgG4 autoantibodies, which are largely unable to activate the immune system, cause disease. Till date at least 29 different diseases classify as IgG4-predominated AID (IgG4-AID). Why certain AID are predominated by IgG4 autoantibodies is not known, but this is confirmed to be critical for precipitation, mechanism and treatment of the disease. In fact selective permissive determinants for class switching to IgG4 in general are not known. Recently, I realized that in contrast to IgG1 autoantigens, IgG4 autoantigens are single pass transmembrane proteins which are continuously shed from the cell. I therefore hypothesize that a key element of the aetiology of IgG4-AID is IgG4-AID antigen shedding resulting in chronic, systemic antigen stimulation in the absence of ‘danger’ signals like bacterial antigens, viral antigens or cellular damage. The goal of this project is therefore to unravel the antigenic and environmental cues that initiate and drive IgG4 (autoreactive) responses following this innovative paradigm, and to find strategies to specifically reduce pathogenic IgG4 responses. I will study this hypothesis using the archetypical IgG4-AID MuSK myasthenia gravis as a model. The combination of state-of-the-art antibody technologies including human lymphoid organoids and AI-based antigen-antibody modelling, with my IgG4 autoimmunity expertise and our set of patient-derived monoclonal antibodies, puts me in an unique position to address the goal of this project. I furthermore aim to provide a first proof of concept for specifically targeting IgG4+ B cells in vitro to pave the way for new therapeutic strategies for IgG4-AID and other IgG4-associated diseases

Keywords: autoimmune disease,igg4,antibodies,myasthenia gravis,class switching