Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease (UPRECON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 134462.4
EU funding (EUR): 134462.4
Participants: 2
Project status: CLOSED

Projections indicate that, by 2050, every person aged 85 years or more will be diagnosed with a cognition-related disease. While there is currently no clear strategy for curing such diseases, there are promising developments in the early diagnosis of disease and the inhibition of worsening symptoms. Building on results obtained during my post-doctoral work regarding laser technology for amyloid aggregates detection, I propose to use an advanced ultrafast spectroscopy for structural analyses of the peptides and proteins that form the different fibril architectures in the brains of patients with pathogenic aggregates. In combination with multiphoton absorption, this laser technique has the potential to detect and diagnose in a non-invasive modality the early forms of toxic oligomeric intermediates in the brains of persons with suspected Alzheimer´s or Parkinson´s disease. This methodology has potentially enormous benefits for patients and society. Importantly, the proposed approach of using high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and it reduces the need for surgical intervention, as it is non-invasive and safe for human health. I will transfer the knowledge and expertise on biophotonics of amyloid fibrils to Europe and the Host laboratory at the Polish Academy of Science will provide me with advanced training in time-resolved ultrafast laser spectroscopy and access to newly designed setups, as well as supplementary career path-specific training in ancillary skills.

Keywords: amyloid fibrils,peptides aggregation,laser detection,biophotonics,structure recognition
Changing Energy Efficiency Technology Adoption in Households (CHEETAH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Sweden,France,Netherlands,United Kingdom
Call: Socio-economic research on consumer's behaviour related to energy efficiency (H2020-EE-2016-RIA-IA, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 1498708.75
EU funding (EUR): 1498708.75
Participants: 9
Project status: CLOSED

Modelling analyses typically suggest that policies accelerating the adoption of energy-efficient technologies (EETs) by overcoming barriers to energy efficiency in the residential sector provide benefits for individual households, the energy system and for society as a whole. Yet, implicit discount rates, employed to reflect households’ decision criteria and response to policy, are disputed in policy and academic circles. CHEETAH (CHanging Energy Efficiency Technology Adoption in Households) provides evidence-based input to energy efficiency policy design and evaluation, thereby supporting the market uptake of EETs in the EU residential sector. It contributes to the work programme by addressing the interrelations between microeconomic factors, sectoral energy demand and macroeconomic effects, relying on a consistent methodological framework. CHEETAH: • Provides empirical evidence on household response to established and new energy-efficiency policies and on factors driving adoption of EETs, accounting for differences across households, technologies, and countries. A multi-country survey (2000 interviews per country) will be carried out and analyzed econometrically • Assesses the impact of established and new policies energy demand in the EU residential sector until 2030 (meso-level). Established vintage stock energy models will be employed for appliances (FORECAST) and for buildings (Invert/EE-Lab) and linked with an agent-based modelling approach (ABM) • Explores the macro-level impacts of changes in microeconomic decision-making and energy-efficiency policy on employment, GDP and exports until 2030, relying on simulations with a recognized macroeconomic model for the EU (ASTRA) • Offers evidence-based recommendations for key energy efficiency policies and input for impact assessments and policy analysis at the three levels of analysis. • Communicates empirical findings to policy makers, national experts, the re-search community and the general public

Keywords: investment behaviour,policy response,implicit discount rates
Longitudinal employer–employee perspectives on the role of human capital investments for retirement transitions (LEEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

European and national ageing policies give high priority to increasing retirement age and employability of older people, but no effective solution exists. The project aims to provide practical recommendations based on evidence on the role of human capital investments (at individual and company level) for retirement transitions. This is still an understudied area in ageing research. It is also neglected by policy-makers who miss the fact that employees must be willing and able to work longer, and employers must be willing and able to provide adequate opportunities for extended employment. The project offers an innovative and comprehensive approach to integrate individual and company perspectives theoretically and empirically in a system-level context. It compares two countries that differ greatly across many aspects relevant to retirement decisions, this is Poland and the Netherlands. Empirical evidence is based on longitudinal (panel) data of individuals and employers (supplemented by cross-sectional data). The research adopts a lifecourse approach, considering employment situation and retirement decisions of individuals as a part of life-trajectory. The results will be intensively disseminated among scientist, experts, and policy-makers. They will be also communicated to older people, employers, training and development organisations. The researcher will be based in the 'Work & Retirement' group in NIDI (Netherlands Interdisciplinary Demographic Institute, part of KNAW) – a leading international institute for population studies, particularly for research on employers’ attitudes and behaviours towards ageing workforce. Professor Kène Henkens, a renowned expert in research on ageing labour markets and retirement, will be the supervisor. Training and two-way knowledge transfer will focus in particular on skills in longitudinal statistics and writing, and on knowhow of project management.

Keywords: retirment,lifelong learning,human capital
Controlling interfacial spin effects in magnetic devices through applied electric fields (Magintlec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 191325.6
EU funding (EUR): 191325.6
Participants: 1
Project status: CLOSED

Sandwiching ultra-thin out-of-plane magnetized materials between heavy metal and oxide layers in multilayer heterostructures has led to important new discoveries which offer a path to fast, non-volatile, low power electronics. The first important effect, the Dzyaloshinskii-Moriya interaction (DMI), favours orthogonal alignment of neighbouring spins, causing stable Néel domain walls of well-defined chirality. The second, spin-orbit torques (SOTs), are torques on the magnetization caused by spin accumulation under applied in-plane currents. In combination these effects lead to very high domain wall velocities and allow the creation of mobile topological objects called skyrmions, both suitable for technological applications. While DMI and SOTs are dominated by the interfaces, their precise microscopic origins are not well understood. This proposal takes advantage of newly developed techniques to control magnetic interfaces with electric fields. Through strain effects, created by electric fields on a ferroelectric layer, or through electrical fields across an insulating oxide or through electric field-induced oxygen migration in an ionic conductor, the interfacial properties of suitable devices will be altered. All these effects change the filling of hybridized interfacial electronic orbitals, which allows the strength of the DMI and SOTs to be tuned for applications and lead to a better understanding of the underlying mechanisms. Magintlec will be conducted at Aalto University where the host group provides frontier expertise and state-of-the-art experimental facilities for electric-field controlled magnetism (film growth, lithography, magnetic and magnetotransport characterization). The applicant, Dr Rhodri Mansell, brings an excellent track record in nanomagnetism and spintronics. For the last five years, he worked as a postdoctoral research associate at Cambridge University focusing on spin-orbit effects and logic devices in out-of-plane magnetized multilayers.

Keywords: spin orbit coupling,electrical control of magnetism
Methyl Donating artificial organelles to support liver cells in Non-alcoholic fatty liver disease (MetD-AO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, encompassing a spectrum of liver damage. Multiple issues are involved on the cellular level in failing liver often including enzyme deficiencies such as reduced biosynthesis of S-adenosylmethionine (SAMe). Preserving SAMe homeostasis has only recently started to be considered as a potential therapeutic target in liver-related medical conditions. However, employing the required enzyme, SAMe synthetase (SAMe-synth), as a pharmaceutical, is challenging due to the general issues involved in intact (functional) protein delivery. The aim of the MetD-AO project is to assemble organic SAMe-synth activity mimicking polymer nanoparticles as artificial organelles (AO) and their in vitro characterization of intracellular function in hepatocytes. AOs are typically nano-sized single compartment reactors, aimed to perform a specific encapsulated biocatalytic reaction within a cell to substitute for missing or lost function. The AO will be based on amphiphilic copolymers consisting of a methyl-donating unit, cholesterol methacrylate and poly(5-carboxypentyl acrylate) as membranolytic hydrophilic tail. The latter two will aim at facilitating self-assembly and lysosomal escape, respectively. To allow structurally intact AO to escape the lysosome is unique since typically, the carrier is destroyed and only the therapeutic cargo is release into the cytosol. The proposed AOs with methyl-donating ability are highly advanced because the few prior reported AOs with intracellular activity all considered reactive oxygen related aspects at best. The successful outcome of MetD-AO has the potential to open up entirely new therapeutic opportunities in NAFLD. The complementary expertise of my host Dr. Stadler and me, a trained polymer chemist, will ensure a successful conduction of MetD-AO while it will enhance my future career prospects gaining experience in colloidal science and cell biology.

Keywords: cell mimicry,biocatalytic polymer
From Network Verification to Synthesis: Breaking New Ground in Network Automation (SyNET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Nearly half of Japan without Internet for hours; thousands of airline passengers grounded; 600+ emergency calls not received. These are just three recent illustrations of the consequences of human-induced network misconfigurations. Such errors are caused by a fundamental gap: distilling the high-level requirements network operators have in mind into complex, low-level device configurations. In 2018, network operators are still trying to bridge this gap manually. The goal of this proposal is to address this gap by automatically synthesizing low-level configurations out of high-level requirements. This is a hard, inter-disciplinary challenge requiring development of new fundamental methods spanning multiple scientific fields including computer networks, programming languages, and probabilistic reasoning. Our vision is akin to program synthesis, a new programming paradigm in which “one tells the computer what to do, not how to do it”. We propose to address this challenge via three work packages: (i) user-aware synthesis where we develop techniques to facilitate how operators communicate their intents and define the space of configurations to search over; (ii) robustness-aware synthesis where we develop synthesis techniques that can enforce probabilistic properties (e.g., minimum reliability level) in uncertain network environments; and (iii) performance-aware synthesis where we develop methods to synthesize more performant configurations (e.g., to make the network converge faster). We believe SyNET will trigger a paradigm shift and spearhead the next generation of network management tools blending formal methods, probabilistic models, and user-intuitive interfaces. By alleviating the need to configure networks, SyNET promises to avoid the vast majority of downtimes plaguing today’s networks and to make tomorrow’s networks more flexible and, ultimately, more efficient.

Keywords: network control algorithms,network reliability,network management,synthesis,compilation,fault tolerance,distributed systems,configuration synthesis,network verification,routing,internet
Functions And Mechanisms Of Ultraosund In Soy Protein Isolate (SPI)-Pectin Nannoemulsion Preparation (FamousSPNP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-03-28
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: SIGNED

According to the European Commission, in 2050, functional foods will constitute a substantial part of foods on the EU market, which will largely rely on the innovation in improved additives. Nanoemulsions are under investigation as a mechanism for the delivery of bioactives to food systems, and are found to have benefits such as improving the taste and bioavailability of numerous ingredients. Recently, protein-polysaccharide complexes and conjugates are being developed for use in the creation of nanoemulsions. However, poor functionality and low production efficiency greatly limit their industrialisation. Therefore, this study proposes to introduce ultrasound technology to complexes/conjugates preparation, aiming at obtaining innovative nanoscale additives with strengthened efficiency and properties. This project will be carried out during a 2-year period at Teagasc with a 3-month secondment in Trinity College Dublin. Soy protein isolate (SPI) and pectin are selected as wall materials for nanoemulsion preparation. Firstly, they will be modified to generate simpler segments for electrostatic or Maillard reaction and the optimum structures for different reactions will be determined (WP1). Then, ultrasound will be applied respectively to electrostatic and Maillard reaction; its free radical and mechanical effects will be studied (WP2). Finally, the delivery properties of ultrasound-prepared SPI-pectin complexes/conjugates will be investigated with β-carotene as a core material, and the effect of the formation mechanisms of nanoemulsions on their functionalities will be analysed (WP3). Results of this study will contribute to the industrial applications of ultrasound in food additive production, thus promoting the development of high-tech functional foods in the EU, and advancing the goal of “sustainable production of food” proposed in Horizon 2020.

Keywords: ultrasound,soy protein isolate,pectin,nanoemulsion,electrostatic interaction,maillard reaction,structural modification,structure,functional property,delivery property
Developing the next generation Macro-Algae based biofuels for transportation via advanced bio-refinery processes (MacroFuels)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Research and Innovation actions
Countries involved: Iceland,Austria,Belgium,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark,Denmark
Call: Developing next generation technologies for biofuels and sustainable alternative fuels (H2020-LCE-2015-1-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5999892.5
EU funding (EUR): 5999892.5
Participants: 13
Project status: CLOSED

MacroFuels aims to produce advanced biofuels from seaweed or macro-algae. The targeted biofuels are ethanol, butanol, furanics and biogas. The project will achieve a breakthrough in biofuel production from macroalgae by: • Increasing the biomass supply by developing a rotating crop scheme for cultivation of seaweed, using native, highly productive brown, red and green seaweeds. Combined with the use of advanced textile substrates these breakthroughs will result in a year round biomass yield of 25 kg seaweeds (wet weight) per m2 per year harvested at 1000m2/hr; • Improving the pre-treatment and storage of seaweed and to yield fermentable and convertible sugars at economically relevant concentrations (10-30%); • Increasing the bio-ethanol production to economically viable concentrations of > 4%/l and; • Increasing the bio-butanol yield to 15 g./l by developing novel fermenting organisms which metabolize all sugars at 90% efficiency for ethanol and butanol; • Increasing the biogas yield to convert 90% of the available carbon in the residues by adapting the organisms to seaweed; • Developing the thermochemical conversion of sugars to fuels from the mg. scale to the kg. scale; • Performing an integral techno-economic, sustainability and risk assessment of the entire seaweed to biofuel chain. MacroFuels will develop technology for the production of fuels which are suitable as liquid fuels or precursor thereof for the heavy transport sector as well as potentially for the aviation sector. The technology will be taken from TRL3 to TRL 4/5. MacroFuels will expand the biomass available for the production of advanced biofuels. Seaweed does not need fresh water, arable land or fertilizers to grow, which provides environmental benefits, and in addition has a high carbon dioxide reduction potential as well as reduces the demand for natural resources on land. The technology offers many novel opportunities for employment along the entire value chain.

Keywords: macro algae,cultivation,rotating crops,biofuel production,ethanol,butanol,furanics,biogas,proteins,system assessments,risk mitigation,transport fuels
European Joint Doctorate in Teacher Education (EDiTE-EJD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Austria,Hungary,Poland,Hungary,Poland,Romania,Romania,Czechia,Portugal,Portugal
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2020-02-29
Duration (months): 53.0
Total project cost (EUR): 3472230.3
EU funding (EUR): 3472230.24
Participants: 24
Project status: CLOSED

The EDiTE joint research programme is a response to the current challenges in the complex processes of transformation of education professionals' career development. Particularly in focus is the teaching profession as central to all education systems. In the research area it is essential that typical national or regional perspective found in TE programmes are extended to include transnational perspectives. A European perspective on the academic level can only be fostered through joint European research. The EDiTE programme is a PhD programme for professionals, which determines the philosophy and values of the curriculum. The most important implication is that researchers/PhD candidates are initiated into academia and versed in high-quality research, co-constructing research questions and applying appropriate methodology in response to practical and theoretical questions emerging from and in practice. Because the field of education is multi-disciplinary and involves different levels the EDiTE programme is targeted at professionals involved in teaching and learning at all points in their professional lives (lifelong learning) including qualified teachers and other professionals. The doctoral candidates will be involved in collaborative research, with individual approaches contributing to the transnational knowledge base within a common framework. A key aspect of the joint research activities is ensuring institutional and transnational knowledge sharing and transfer between universities and schools or other educational institutions. The overarching research theme “European perspective on transformative professional learning in relation to the impact of teaching” includes not only the issues of “European teacher” and “Europeanness” in education systems, but it also focuses on learning which is transformative in a professional context.

Keywords: teacher education,teacher professional development,education policy,school management and leadership,school and teacher education research,european school education systems