Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unobtrusive Continuous Multi-Metabolite Monitoring for a Physiological Care of Insulin-treated Diabetes (MuSiC4Diabetes)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Italy,France,Belgium
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 3885462.5
EU funding (EUR): 3885462.5
Participants: 7
Project status: SIGNED

It will be a radically new approach for long-term continuous monitoring of insulin-treated persons with diabetes (ITD) moving from a glucose-only to a multi-metabolite monitoring - glucose, lactate and 3 ß OH-butyrate– paradigm. Multi-metabolite monitoring will also lead to a diabetes therapy breakthrough by algorithmically driving a continuous physiologic insulin delivery by a maintenance-free implanted MEMS pump using the peritoneal route enabling an optimal therapy for subjects with ITD. Our vision is a fully implantable artificial organ to replace insulin secretion loss by targeting metabolic health instead of mere glucose control and mimicking physiological insulin action. While offering a really burden-free life for insulin-treated children and adults, it is expected to allow a dramatic reduction of metabolic variations, hence a minimization of acute and long-term complications and an abating of the still high mortality of T1D patients. Unobtrusive living with diabetes will be reached by the calibration-free, implantable, long-term multi-metabolite monitoring solution connected wirelessly to a novel highly miniaturized silicon MEMS micropump, with down to 50 nl stroke volume, able to operate a newly developed U1000 insulin and enabling reservoir refill cycles of 180 days up to 365 days. Both devices hold durable battery operating life of more than 8 years without recharge and are suitable for children. Newly designed control algorithms based upon multiple signal inputs will drive automated insulin delivery without the need of obtrusive meal and physical exercise announcements.

Keywords: biomedical engineering,diabetes technology,multi metabolite sensors,micropump,peritoneal insulin delivery,control algorithm,closed loop systems,patient outcomes
Easy to use, contactless Dual-Mode Ultrasound Technology for high accuracy treatment of Atrial Fibrillation, improving outcomes (DMUT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 11369502.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Our mission is to radically change the landscape of cardiac ablation. Our products, based on proprietary ultrasound technology, allow contactless tissue ablation with real-time lesion monitoring, bringing Healium to the forefront of the cardiac ablation market. Our team, backed by scientific and business advisors, includes Dr. Eckhouse, Chairman, leading medical entrepreneur who has founded >20 companies, and cumulated >€1B in exits (Ventor for $325M, Synron and Lumenis both IPO > $1B). Ran Sela, CEO and co-founder, >15 years of medical device development and project management. Dr. Megel, CTO, and co-founder, >25 years in ultrasound-based medical devices. Now, we are at the top-risk phase of our development journey: the transition from preclinical to clinical studies. Leveraging an EC investment of €12.75M we can demonstrate the efficacy and safety of our product, establish a manufacturing line and regulatory framework, and access the market as a self-sustained company.

Keywords: electrophysiology,microelectronics,ultrasound,catheter ablation,cardiology,engineering and technology,atrial fibrilation
Identifying and developing adaptive skills for facing transformation (Birth of Core-Skill)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

This groundbreaking solution in the field of skills development enables for the first time a qualitative analysis of soft-skills and optimise it’s development. Rising Up provides an integrated software solution called THE LAB for identifying and developing the soft (core)skills that are needed to access the job market.

Keywords: softskills,education,webapp,react,personalization,smartdata,employability
Reinventing Symmetric Cryptography for Arithmetization over Large fiElds (ReSCALE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1488988.0
EU funding (EUR): 1488988.0
Participants: 1
Project status: SIGNED

Symmetric cryptography is finding new uses because of the emergence of novel and more complex (e.g. distributed) computing environments. These are based on sophisticated zero-knowledge and Multi-Party Computation (MPC) protocols, and they aim to provide strong security guarantees of types that were unthinkable before. In particular, they make it theoretically possible to prove that a computation was done as claimed by those performing it without revealing its inputs or outputs. This would make it possible e.g. for e-governance algorithms to prove that they are run honestly; and overall would increase the trust we can have in various automated processes. The security techniques providing these guarantees are sequences of operations in a large finite field GF(q), where typically q>2^64. However, these procedures also rely on hash functions and other "symmetric" cryptographic algorithms that are defined over GF(2}={0,1}. But encoding GF(2) operations using GF(q) operations is very costly: relying on standard hash functions leads to significant performance overhead, to the point were the protocols mentioned before are unusable in practice. In order to alleviate this bottleneck, it is necessary to devise symmetric algorithms that are natively described in GF(q). This change requires great care: some hash functions described in GF(q) have already been presented, and subsequently exhibited significant flaws. The inherent structural differences between GF(2) and GF(q) are the cause behind these problems: our understanding of the construction of symmetric primitives in GF(2) does not carry over to GF(q). With this project, I will bring symmetric cryptography into GF(q) in a safe and efficient way. To this end, I will rebuild the analysis tools and methods that are used both by designers and attackers. This project will naturally lead to the design of new algorithms whose adoption will be simplified by the efficient and easy-to-use software libraries we will provide.

Keywords: symmetric cryptography,zero knowledge protocols,arithmetization friendly,hash function,cryptanalysis
Rebuilding governance and resilience out of the pandemic (REGROUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,Italy,France,Spain,Ireland,Belgium,Cyprus,Poland,Austria,Germany,Norway
Call: Politics and governance in a post-pandemic world (HORIZON-CL2-2021-DEMOCRACY-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3060653.75
EU funding (EUR): 2999996.75
Participants: 14
Project status: SIGNED

Culminating more than a decade of crisis in Europe, the Covid-19 pandemic has opened an unprecedented window of opportunity for institutional and policy change, not only at the “reactive” level of emergency responses, but also to tackle more broadly the many socio-political challenges caused or exacerbated by Covid-19. Building on this premise, REGROUP (Rebuilding governance and resilience out of the pandemic) aims to: 1) provide the European Union with a body of actionable advice on how to rebuild post-pandemic governance and public policies in an effective and democratic way; anchored to 2) a map of the socio-political dynamics and consequences of Covid-19; and 3) an empirically-informed normative evaluation of the pandemic. REGROUP pursues this threefold objective via a multi-level (national, supranational, international) and multi-sphere (political, societal, ideational, digital) research approach, and guided by three overarching analytical themes: “reordering”; “risk”; “resilience”. We operate in nine collaborative work packages—grouped in three blocks: “diagnosis”, “evaluation”, and “prescription”—bringing together expertise and methods from a range of social sciences and humanities. Doing so, we advance the state of the art conceptually, theoretically, and methodologically. REGROUP is conducted by a consortium of 13 internationally renowned institutions, committed to scholarly excellence, inclusiveness, and open science. The project is designed to achieve a high degree of policy, societal, and scientific impact, which it will achieve via a multi-pronged dissemination and communication strategy. This includes links to some of the EU’s main debates and events, such as the Health Union, the Green Deal, the Digital Decade, the Economic Governance Review, the Conference on the Future of Europe, and the 2024 European Parliament elections.

Keywords: covid 19 european union crisis critical juncture institutional change liberal democracy deliberation multi level governance global governance risk resilience disinformation digitalisation
Boosting QCD Studies with Bootstrap Tools (QCD-BOOST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: TERMINATED

In this project we are embarking on the ambitious and exciting journey to advance our understanding of Quantum Chromodynamics (QCD) in 4d, a fundamental theory that describes interactions among quarks and gluons. Our primary focus will be on studying QCD in two different regimes: in the physical regime with two flavours of quarks and in the conformal window. In the physical regime QCD is the theory of Strong interactions responsible for the existence of mesons, baryons and nuclei. QCD in the conformal window holds significant relevance from the purely theoretical prospective and might describe physics beyond the standard model. Although significant progress has been made in studying QCD, its complete understanding remains a challenge. In the last decade there has been an incredible development of bootstrap tools which we will use in this project to obtain a series of groundbreaking results about QCD which are difficult or impossible to obtain by other means. We will use the S-matrix bootstrap to study QCD in the physical regime. Our main goal is to find numerically crossing symmetric, analytic and unitary expressions for scattering amplitudes of pions, protons and neutrons, and perform spectral analysis of resonances described by complex energies. As a secondary goal we will compute non-perturbatively the scattering amplitude in the 3d phi4 model. We will use the conformal bootstrap to study QCD in the left part of the conformal window and perturbation theory to study QCD in the right part of the conformal window in the Veneziano limit. We will attempt to determine the spectrum of Caswell-Banks-Zaks fixed points on both sides. As a secondary goal we will also obtain rigorous bounds on the trace anomalies in generic 4d conformal field theories. Since the bootstrap tools are model independent, in order to study QCD we will augment them with QCD model dependent data which comes from experiments, numerical simulations and ('t Hooft and trace) anomalies.

Keywords: qcd,s matrix bootstrap,conformal bootstrap,pions scattering,resonances,conformal window
The role of SOcial ecoNomY in Addressing social exclusion, providing quality jobs and greater sustainability (SONYA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: France,Spain,Italy,Bulgaria,Australia
Call: The role of social economy in addressing social exclusion, providing quality jobs and greater sustainability (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 2965081.25
EU funding (EUR): 2965081.25
Participants: 9
Project status: SIGNED

With a growing aging population, the EU faces increased demand for quality social elderly care. However, intricate legal and policy landscapes for Social Economy organizations (SEs) contribute to poor working conditions, gender bias and innovation challenges, hindering the provision of sustainable and inclusive social services by SEs. This is particularly exacerbated in rural areas, where access to facilities and technology deployment and logistics is complicated. The EU context is facing the urgent need for affordable services and to rethink the dominant recipient model of social care, which challenges the sense of dignity, identity and quality of life of both elderly people and care givers. SONYA emerges as a pioneering initiative to assess the role of SEs in retaining and attracting social elderly care workers to foster social innovation effectiveness in rural areas. Our vision seeks to scale up SEs successful activities beyond tool, support services and methods development by empowering SEs to develop participatory multi-actor networks and social and environmental community initiatives, identifying and transferring social innovations for inclusive employment and better working conditions while measuring impact with scientific precision for improving legal and policy frameworks supporting SEs. SONYA is implemented by a consortium of scientific partners with expertise in operationalising multi-actor participatory models, sustainability assessment, workers' rights and effective representation, and policy making; enabling entities representing 3 EU SEs models varying in size, network development and national context; and support actors. SONYA will facilitate a transition towards more respected, inclusive and valued social elderly care services, beyond medical care. Targeted SEs will be able to efficiently create quality jobs, contribute to equal opportunities and socioeconomic inclusion of disadvantaged groups and help revitalise EU’s rural and depopulated areas.

Keywords: social elderly care rural areas participatory network models sustainability and impact assessment frameworks
A right to repair for a post-growth society: Controversies, opportunities and challenges (R2R4postgrowth)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

The need to continuously stimulate consumer demand within saturated capitalist markets has driven manufacturers of electronic equipment to adopt dubious marketing practices associated with planned obsolescence (e.g. they might artificially shorten the lifespan of their products, downplay issues of durability and maintenance during the design stage, and on). The social and ecological costs of these trends are enormous, and the world is currently on track to produce 74 million tonnes of e-waste by 2030. In this context, there is mounting pressure on manufacturers and policy-makers to facilitate consumers the "right to repair" (R2R) their electronic devices, rather than relying on the manufacturer to make/authorise repairs with proprietary components. This demand has sparked a controversy concerning the limits of the R2R, with large multinational corporations such as Apple, Microsoft, Amazon, or John Deere disputing this concept on economic, technical, legal or safety grounds. In this regard, the present project aims at elucidating how ongoing debates and policies about the "right to repair" can be conceptualised and implemented to support a transition towards a postgrowth society. The methodology adopted will be based on controversy mapping, which is widely used in the field of Science and Technology Studies. First, a controversy map will be elaborated, showing the different stakeholders and their evolving positions (both for and against) regarding the R2R. Next, fieldwork will be conducted with grassroots organisations and technology activists involved in the R2R campaign. Finally, I will analyse the R2R in light of contemporary postgrowth frameworks to establish key challenges/opportunities for transforming society-technology relations in more sustainable ways. By doing so, this project pushes forward the boundaries of current knowledge and advances our understanding of the role of technology and innovation in postgrowth transitions.

Keywords: postgrowth,right to repair,e waste
Revealing the fundamental principles of picobodies with broad-spectrum and redox-responsive antibacterial activity (PicoBody)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1493750.0
EU funding (EUR): 1493750.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance is a burning global issue. The available antimicrobials are losing efficacy as resistant bacteria arise, but the industry does not invest enough into antibiotic discovery due to low expected revenues. Natural antimicrobial peptides (AMPs) hold great promise as blueprints for new antibiotics. However, there are few known natural AMPs with sufficiently high potency and low toxicity that enable applications in veterinary and human medicine. As a result, the research on natural peptide antibiotics has been obstructed. New natural AMPs are needed urgently. I propose for the first time that picobodies, recently discovered peptides part of natural cow antibodies, have potent antibacterial activity. In contrast to known mammalian AMPs, picobodies are exceptionally diverse due to the unique bovine immune system. Moreover, all picobodies contain disulfide bonds that enable a redox regulation of their activity (unlike common antibiotics). I suggest that redox-activated picobodies target bacteria in infection sites characterized by a reducing environment such as persistent bacterial biofilms. In PicoBody, I have 4 major objectives: (i) interrogate natural picobody repertoires for antibacterial activity, (ii) investigate if cows can develop antibacterial picobodies against essential bacterial targets, (iii) understand how the redox environment regulates the antibacterial picobody activity, and (iv) evaluate the activity of antibacterial picobodies using in vitro and in vivo models. To achieve my goals, I will employ a multidisciplinary approach based on protein science, molecular biology, microbiology, machine learning, and lab automation. The project will establish key methods for the identification of antibacterial proteins, reveal basic insights about the fascinating bovine immune system, validate picobodies as previously unknown natural AMPs and open new research directions into the discovery of very much needed new peptide antibiotics.

Keywords: bovine antibodies antibacterial peptides picobodies antibodies ultra long cdrs
The causes and consequences of firms’ focus on artificial intelligence (AIFocus)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

The European Union (EU) attaches critical importance to AI. With its new strategy, called the “European approach to AI”, the EU aims to boost investment to foster the uptake of AI by EU firms. While the potential of AI is widely acknowledged, it is not evident that the focus on AI will translate into the targeted economic benefits. To date, we lack empirical evidence about the firm-level consequences of firms’ increasing focus on AI. The reason for this lack of knowledge is a paucity of firm-level data. In this project, I contribute to our understanding of the causes and consequences of firms’ increasing focus on AI by using a large firm-level dataset. First, I use automated textual analysis to create a unique measure that captures firms’ focus on AI. The measure is based on publicly available documents and allows separating between different AI capabilities. Second, I investigate what causes firms to focus on AI. The answer to this question will be of critical importance to policymakers. It helps them to use the most effective mechanisms to increase AI uptake. Third, I investigate the effect of firms’ AI focus on (a) efficiency, (b) innovation, and (c) employment. Understanding the consequences of firms’ increasing focus on AI is crucial for policymakers. The findings of this project guide them in making efficient investments and designing policies that benefit the workforce.

Keywords: information management,firms ai focus,ai capabilities,firm level consequences,efficiency,innovation,employment,automated textual analysis