Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantifying ageing related cognitive decline and mild cognitive impairment (COGDEC)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Belgium,Slovenia
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 799811.25
EU funding (EUR): 799801.25
Participants: 3
Project status: CLOSED

University of Ljubljana, located in a low R&I performing country, will partner with two internationally-leading organisations, the Medical University of Graz and KU Leuven, to expand the support and coordination capacity for national and European research in ageing-related decrease in brain functions leading to dementia. By 2025 more than 25% of European population will be over 60 years old, with people over 80 increasing most rapidly. Cognitive function declines with ageing, but unpredictably, remaining practically stable over time or progress rapidly to dementia, when a person loses the ability to live independently and enjoy a reasonable quality of life. Detection of the transition from a pattern of normal, ageing-related decline to a state associated with the beginning of mild cognitive impairment is crucial for providing long term effective medical support and a better quality of life to ageing people. Several advanced brain imaging methods are used to detect mild cognitive impairment. As no single method is optimal for the early detection, there is an urgent need for further improvement/refinement of these methods. Through this proposed project we will transfer current state-of the art methods in brain imaging, including magnetic resonance imaging, electroencephalography and positron emission tomography, from the two internationally-leading organisations to Ljubljana. This will be achieved by mentored training of early stage researchers and other researchers through workshops, summer schools, short-term on-site training and expert visits. With the two internationally-leading organisations, we will prepare joint collaborative grant proposals and PhD projects during the life time of the Twinning project. These will enable further development of advanced brain imaging methods to study cognitive decline at the University of Ljubljana and sustain the newly formed research and technology network for the foreseeable future.

Keywords: mr imaging,mild cognitive decline,ageing related cognitive decline,brain biomarkers for mild cognitive decline
Extending the attractiveness of transport for end user and extending IP4 to SaaS solutions. (ExtenSive)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Germany,Spain,Italy,Poland,Sweden,France,France,United Kingdom,Portugal
Call: Enhancing IP4 Ecosystem (H2020-S2RJU-CFM-2020, 2020)
Start date: 2020-12-01
End date: 2023-09-30
Duration (months): 34.0
Total project cost (EUR): 7112270.36
EU funding (EUR): 5025512.62
Participants: 16
Project status: SIGNED

ExtenSive project will be part of Shift2Rail (S2R), the first rail joint technology initiative focused on accelerating the integration of new and advanced technologies into innovative rail product solutions. It is framed within the innovation Program 4 (IP4), which addresses “IT solutions for attractive Railway services”. ExtenSive provides complementary and continuous solutions already started within previous projects, MaaSive, ATTRACkTIVE and CO-ACTIVE, to enhance traveller experience and improve the travel services (in the areas of travel shopping, trip tracking, booking and ticketing) and deal with Software as a Service approach. ExtenSive will improve and enhance the current functionalities of IP4 and create synergies with the other S2R IPs to enhance services for users and operators and facilitate information flow among IP4 services and other railway systems.

Keywords: traveller experience,maas,saas
Priscian’s Ars grammatica in European Scriptoria. A Millennium of Latin and Greek Scholarship (PAGES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2486375.0
EU funding (EUR): 2486375.0
Participants: 1
Project status: SIGNED

Written at the beginning of the 6th century AD in the bilingual context of Constantinople, the Ars Prisciani, in 18 books, is the last and greatest Latin grammar handbook of Antiquity. Bringing together the inheritance of Latin and Greek grammatical traditions, it stands as a milestone in the history of linguistic speculation and is an important source of fragments of lost literary works. The deep impact of this text on European culture falls beyond its original scope. Conceived to teach Latin to Greek speakers, in the early Middle Ages (8th-10th centuries) and during the Renaissance (15th-16th centuries) the Ars turned out, due to its great amount of Greek passages, to stimulate the study of Greek by Western scholars. The peculiar East-Western transmission of the Ars can now be exploited and thoroughly illustrated thanks to the progress of digital philology. PAGES aims both to supersede Hertz’s outdated and unreliable edition (1855-59) and, in a broader perspective, to reconstruct Priscian’s key role not only in the revival of Latin in 9th-century Europe but also in the practice of Greek script and language in Carolingian scriptoria, in the renaissance of Greek philological studies in the Humanistic Age, and in the history of linguistic education in Europe. The project tackles these challenges with a multidisciplinary approach, gathering experts in textual criticism, digital humanities, palaeography and multispectral imaging, history of linguistics, and medieval and humanistic scholarship. PAGES will build an open source digital scholarly resource on the text, the tradition, and the reception of Priscian. The infrastructure will make available the results of the systematic census of medieval manuscripts and early printed editions, including the comprehensive inquiry about the Greek script and glosses in Priscian’s 8th-10th-centuries manuscripts as well as about the emendations and interpolations in 15th-16th-centuries manuscripts and printed editions.

Keywords: ancient grammarians,digital philology,late antiquity,latin language and literature,greek and latin fragmentary texts,ancient and medieval bilingualism,carolingian studies,renaissance studies,history of scholarship,history of linguistics
Biophysical Changes in the Sahel: Ground and Satellite Based Evidence Across Scales and Disciplines (BICSA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Human and climate induced desertification has been a major issue for livelihoods and food security in drylands. In this context, the Sahel has been subject to various controversial studies. Earth Observation (EO) studies show a positive trend in vegetation greenness over the last decades, which has been interpreted as an increase in biomass and contradicts prevailing narratives of widespread degradation. However, new scientific outcome suggests a massive loss in biodiversity, which again contradicts the beneficial effects of the greening theory. These apparent oppositions result from little investment that has been made in studying long-term ground data. Thus, the overall purpose of this project is to assess the opposing trends of biomass increase and species decline in the Sahel. By combining a range of long-term in-situ field data records (1980s-today) with EO time series and Very High Resolution (VHR) satellite imagery, an improved understanding on the role of trees, herbs and species on the greening Sahel will be achieved. Trends will be translated in ecosystem services and beneficial effects on livelihoods. Knowing the underlying biophysical mechanisms of the Sahel greening will resolve contradictions regarding the greening/desertification paradigms and thus be basis for future studies. Furthermore, the scientific understanding of linkages between ground and satellite data and their applicability across scales will be improved. New monitoring methods of biophysical variables address challenges in land management and food security. To achieve this, I will be trained in cutting edge skills (EO time series; object based mapping; field monitoring of vegetation productivity/biodiversity; socializing pixels; ecological services). My major mobility activity will be to bring together technically advanced EO studies from the European host and field campaigns from African scientists enforcing a research network to advance our understanding of the re-greening phenomenon.

Keywords: sahel,earth observation,biodiversity,degradation
Tissue-resident Lymphocytes: Development and Function in “real-life” Contexts (TissueLymphoContexts)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-10-31
Duration (months): 68.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8+ T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

Keywords: enviromental shaping of immune responses
Investigating the predictors of intimate partner violence: A mixed method longitudinal study in Tanzania (IPV_Tanzania)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany,Tanzania, United Republic of,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2023-05-31
Duration (months): 69.0
Total project cost (EUR): 1499094.0
EU funding (EUR): 528904.79
Participants: 4
Project status: SIGNED

This study proposes a major advance in research on intimate partner violence (IPV), a prominent public health and human rights issue. Worldwide, it is estimated that one in three women experience physical and/or sexual violence by a partner in their lifetime, with even higher rates reported in sub-Saharan Africa (WHO 2013). Cross-sectional surveys have documented the adverse health impacts of IPV and the factors that increase risk of female victimisation and male perpetration. Nonetheless, theoretical and programmatic development has stalled due to lack of clarity on the temporality of identified associations: do documented associations represent risk factors for violence or do they reflect the consequences of abuse? This deficit of understanding is especially pressing in low and middle income countries (LMICs) where few longitudinal cohort studies with IPV as an outcome exist. This study seeks to address this gap by following forward in time a cohort of 1200 Tanzanian women, using state of the art methods to measure violence, encourage disclosure and ensure participant safety. Both quantitative and qualitative data will be collected at 4 discrete time points over 5 years, making this the largest longitudinal study of IPV ever undertaken in the developing world. In addition, an in-depth study of 40 men and a cross-sectional survey of 600 men will be conducted. The goal of the research is to advance our understanding of the predictors and consequences of IPV to better inform the design of interventions to reduce violence in LMICs. Specifically the study aims to: 1) advance the theoretical frameworks of intimate partner violence; 2) investigate the temporality of key factors linked to IPV; 3) map the dynamics of partner violence over time; 4) and investigate pathways leading to intimate partner violence. This research is of immediate necessity to address a vital public health challenge of our time and has the strong potential to have a long lasting impact on shaping the research agenda on intimate partner violence.

Keywords: violence against women
Bacterial regulation of Apis neurophysiology (BRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Gut microbes are known to affect the neurophysiology of their hosts and genome sequencing now easily allows metabolic characterization of elusive microbial diversity that cannot be cultured. While investigations on the neurological and behavioural consequences of mammalian gut symbionts have grown exponentially in recent years, little is known about the ‘gut microbiota–brain axis’ in insects of major economic interest. The applicant is a molecular evolutionary ecologist who previously used gene expression data to predict physiological modifications in the honeybee after insemination and published a comparative analysis of bacterial symbionts across ants. He now aims to realize an inter-disciplinary program to map the neurological and behavioural extended phenotypes of gut symbionts in bees. Through experimental approaches of microbiome manipulation, neurotranscriptomics, behavioural-tracking, FISH, and isotope-labelling of bacterial metabolites, the project seeks to understand: (i) the extent to which Apis mellifera gut symbionts affect host brain function by identifying the specific bacteria, their metabolic products, and the brain regions involved in host-symbiont interactions, and (ii) assess whether these processes affect behavioural traits relevant for the social organization of bees. None of these objectives have been addressed before and achieving them has high potential to change the way in which biologists think about bacterial symbioses and animal behaviour. The project includes training-through-research for the applicant in microbiology, behavioural ecology, microscopy and bioinformatics, and considerable knowledge transfer in transcriptomics and conceptual symbiosis theory from the applicant to the host groups. Although challenging in its ambitions, the project is synergistic and feasible, and will allow the European Research Area to harvest tangible benefits to improve the health of a domesticated species of primary importance to secure food production.

Keywords: microbiota,apis mellifera,rna sequencing,neurobiology,pollinator health
Virtual Energy Trading IT System to couple photovoltaic production and electric vehicles charging. (Solar Bank)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Solar Bank is a virtual energy trading IT platform that links the solar energy produced by photovoltaic energy plant and the electricity consumed in Electric Vehicles charging stations. Solar Bank is the basis for the issuing of Guarantees of Origin (GO), that are bought by Solar Bank from the producer and sold to the consumers. Algorithms are implemented on the platform to connect the production to the consumption in the most efficient way (proximity logic) and to dynamically assess the PV electricity and GO costs, perfectly matching the needs of both PV plant owners and EV charging station managers. Solar Bank is conceived at a "city-scale" and its proximity logic allows a steep reduction of Transmission and Distribution inefficiency by 50%. The IT platform has been validated in the city of Uppsala (Sweden), where 14 production nodes and 248 charging nodes are connected to the platform, attesting its potentiality and the appreciation of the End-Users. Moreover, Solelia IT solution is covered by copyright protection as a computer programme, and the "Solar Bank" brand is protected. Now, the technology owner Solelia intends to develop the final product implementing a block-chain functionality for GO trading and extending the solution validation in two medium sized European cities (> 300,000 inhabitants), in order to definitely enter in the European market. During the SME-Instrument Phase 1 project, Solelia will deliver a complete Business Plan, confirming the yearly subscription fee for end-users (photovoltaic plants and Electric Vehicles charging equipment owners) through a Customer Validation, extending the GO mechanisms analysis in all European countries, involving private investors, key stakeholders and potential customers, closing agreements with two European cities municipalities for the final product full validation.

Keywords: city scale it platform for electricity trading,guarantees of origin,photovoltaic production
COHErent Setup and Demonstration of Integrated Travel SerVices (COHESIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Spain,Sweden,France,United Kingdom,Portugal
Call: IP4 overall integration and demonstration (H2020-S2RJU-CFM-2017, 2017)
Start date: 2017-09-01
End date: 2022-12-31
Duration (months): 64.0
Total project cost (EUR): 2564500.0
EU funding (EUR): 1795150.0
Participants: 8
Project status: SIGNED

Coordination and demonstration embracing all areas of IP4 and targets aiming to assist support ensure and promote a common technical approach across the IP4 to allow integrated and coherent Technical Demonstrations as outlined on Shift2Rail master plan. Te objective will be achieved through different activities involving and promoting the collaborative participation of associated projects (for members of Shit2Rail and from open calls) and the partners involved, through the close technical interface with the different projects and the coordination of the integration activities activities to support and achieve consistency and convergence amongst the different projects, feeding a reliable set of technical packages.