Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rethink, Reduce and Refuse: Can the Food Industry change fundamentally to meet UN Sustainable Development Goal 12? (FOODRED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

FOODRED examines whether food systems can be rethought and activities that lead to oversupply and overproduction reduced or refused. This would require boards of major food companies to direct their businesses to make substantial changes, which is difficult when profit margins are very narrow in many food businesses. This would require leadership from Boards and Executive Officers, and so there is a need to understand how Boards and Executives might influence the adoption of more radical 'reduce' and 'refuse' principles in their corporations, and which persons in those roles have the greater influence to drive change. Unless businesses are prepared to consider changing the prevailing business models, the food systems will be vulnerable to collapse in supply even more damaging than that seen in Europe during the 2019-21 Covid pandemic. We ask what it would take for corporations to explore the potential for increased profits through savings and for enhanced corporate responsibility through reducing wasteful activities, and which members of the Board are likely to drive that change. There is also the question of whether better Economic and Social Governance (ESG) would enhance the reputation and therefore drive customer growth, if these more difficult steps were taken. Furthermore, FOODRED would examine the role of women board members and executives in the drive for CE principles within firms, investigating whether there are links between SDG12 and SDG5.5.2. This also tests whether the OECD findings on the roles of women in achieving a CE are evident at the highest levels in corporations. There are very few studies that currently address these questions and as well as contributing to academic knowledge, our work has high potential for making a contribution to policy making in corporations, government and supra-international level for those looking for how to persuade corporations to do business for purpose rather than profit.

Keywords: food supply chain,sustainability,strategic management,diversity,gender
Career Advancement, Policy Impact, and Networking for the MSCA Community (CAPTAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to the Marie Curie Alumni Association (HORIZON-MSCA-2024-ALUMNI-IBA, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 3998998.75
EU funding (EUR): 3998998.75
Participants: 1
Project status: SIGNED

The CAPTAIN project aims to bolster the impact of the Marie Skłodowska-Curie Actions (MSCA) by supporting the operations and goals of the Marie Curie Alumni Association (MCAA) while introducing enhanced services. With over 22,000 current and former MSCA fellows, the MCAA serves as a pivotal international non-profit organisation facilitating networking, career advancement, and policy influence within the MSCA community. By harnessing the expertise and experiences of its diverse membership, the MCAA not only fosters professional connections but also contributes to shaping EU policies, particularly those related to MSCA programmes. Building on the successes and insights gained from the MCAA-New-Horizon project (2022-2024), the CAPTAIN project focuses on three core areas of activity aligned with the objectives outlined in the Horizon Europe Work Programme. Through strategic initiatives, it seeks to empower MSCA professionals, elevate the visibility of MSCA initiatives globally, and inform policy development to further enhance the impact of MSCA programmes.

Keywords: mcaa,career development,policy,msca impact
Building decentralIsed, DistributEd And Local micro-GRids for dEcarbonisation Electrification challeNge (IDEAL4GREEN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,France,Germany,Greece,Norway,Sweden,Denmark,Finland,United Kingdom
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4083364.8
EU funding (EUR): 4083364.8
Participants: 19
Project status: SIGNED

The IDEAL4GREEN project addresses the urgent challenges of climate change and the global shift towards sustainable energy systems. It focuses on developing and integrating microgrids, which are crucial in managing the variability of renewable resources and achieving decarbonisation targets. The project aligns with the EC's commitment to carbon neutrality by 2050 by empowering energy communities and optimising local supply and demand. The project proposes a comprehensive doctoral training network aimed at developing skilled engineers with interdisciplinary and inter-sectoral expertise. This network diverges from conventional university-based research, maintaining strong industry links and emphasising practical implementation. IDEAL4GREEN consists of 8 beneficiaries and 11 partner organisations, recruiting 15 doctoral candidates to undertake research on microgrids' planning, design, operation, control, and impact assessment. The research encompasses innovative frameworks and methodologies for integrating microgrids and transforming traditional grids into sustainable energy systems. This includes developing advanced control algorithms, cybersecurity, improving mechanisms for microgrid islanding and reconnection, and enhancing the resilience and reliability of interconnected microgrid systems. The project also explores the planning, policy, and economic feasibility of interconnected grids and microgrids. It emphasises creating complete and integrated microgrid design frameworks, utilising integrated energy system modelling, and investigating regulatory policies. In terms of training, the DCs will engage in a mix of academic and industrial experiences, including secondments and networking meetings, ensuring their exposure to both theoretical knowledge and practical skills. The training program covers various aspects, such as advanced technical skills, collaborative communication, critical thinking, problem-solving, and adaptability.

Keywords: microgrids,electrification,renewable energy,electrical grids,distribution systems
Assessing efficacy and safety of genome EDITing approaches for Sickle Cell Disease (EDITSCD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: France,Italy,Germany,Israel,Sweden,Netherlands,Switzerland,Poland
Call: Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 6532000.0
EU funding (EUR): 6532000.0
Participants: 9
Project status: SIGNED

Sickle cell disease (SCD) is one of the most prevalent monogenic diseases in Europe. A single amino acid substitution in the beta-globin chain of the adult hemoglobin (Hb) drives red blood cell sickling and multi-organ damage. The clinical severity of SCD is alleviated by the co-inheritance of mutations causing expression of fetal gamma-globin in adult life ? a condition termed hereditary persistence of fetal hemoglobin (HPFH). Transplantation of autologous, genetically modified hematopoietic stem/progenitor cells (HSPCs) is an attractive therapeutic option for SCD patients. To this end, genome editing approaches based on the use of site-specific nucleases or, more recently, base editors have been explored by many groups, including teams in our consortium. These approaches either correct the single point mutation causing SCD or reactivate fetal gamma-globin expression by mimicking HPFH mutations. On the other hand, (pre)clinical data from SCD patients or SCD mouse models, as well as preliminary data from our labs suggest that SCD HSPCs are characterized by a high mutational burden, oxidative stress and expression of inflammatory genes. This can alter HSPC properties as well as their interactions within the bone marrow niche. In the context of gene therapy, it is essential to understand the mechanisms underlying SCD HSPC dysfunction and assess the impact of genome editing approaches on SCD HSPCs. In this proposal, we have assembled a multidisciplinary team to: (i) understand the molecular and cellular mechanisms underlying SCD HSPC autonomous and non-cell-autonomous dysfunctions and (ii) evaluate the impact of established and novel genome editing approaches on SCD HSPC properties and genome integrity. This study will lay the foundation of an improved gene therapy strategy to treat SCD and provide best practice tools and protocols for genome editing-based therapies in HSPCs.

Keywords: genome editing,crispr cas9,safety
IMPACT OF ALTERNATIVE PROTEIN SOURCES TO IMPROVE NUTRITION (PROTEIN4IMPACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Germany,Bulgaria,France,Austria,Sweden,Cyprus,Czechia,Italy,Spain,Greece,Portugal,Denmark,Malta
Call: Impact of the development of novel foods based on alternative sources of proteins (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 5273375.0
EU funding (EUR): 5273375.0
Participants: 18
Project status: SIGNED

PROTEIN4IMPACT aims at evaluating the nutritional, health, safety and quality aspects together with the environmental and socio-economic impacts of protein novel foods (NFs) obtained from unconventional sources. In order to close the project loop by maximizing the positive impact on the transition towards healthier, protein NFs, the overall approach to alternative protein production in PROTEIN4IMPACT is based on utilization of selected agri-food and fisheries & acquaculture by-products as primary feedstock as well as on the utilization of natural protein producers, i.e. fungi, bacteria, insects micro- and macroalgae. The secondary by-products formed along the value chain will be up-cycled for their use in the food production cycle or for the production of process energy. The obtained proteins will undergo modification and functionalization followed by a sensory evaluation and testing in food human trials and in aquaculture as feed ingredients. The project will also test the feasibility of producing NF products by simulating realistic industrial scale, using different methods and tools such as LCA, LCC, RA, and TEA as well as Digital Twins and real time AI-driven monitoring and DSS tools. The optimization of parameters affecting the protein NF production will be evaluated at the end to increase protein content and the impact assessment evaluated on each single stage (extraction, characterization, modification/functionalization of protein rich fraction, production of NFs) and on the integrated processes. PROTEIN4IMPACT NF acceptance and social relevance –also through sensory evaluation actions- will be assessed in four markets (Europe, USA, Africa and Asia) to benchmark the European scenario with the rest of the world. Only by using an integrated approach like the one proposed in PROTEIN4IMPACT will it be possible to evaluate the correct feasibility in the use of alternative proteins in the food sector with a realistic sustainable approach.

Keywords: protein novel foods,social impact of novel foods,sustainable approach,environmental impact assessment,economic impact assessment,by product valorizations,closing the loop on food production
How European Big Cities and Legal Systems Trigger Urban Inequality: An Inquiry into Law and Economics (HABITAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1497340.0
EU funding (EUR): 1497340.0
Participants: 1
Project status: SIGNED

HABITAT is based on a groundbreaking research hypothesis (GbRH): socioeconomic inequality in major European cities is largely due to a history of regulatory failures of urban legal systems. Urban legal systems have played a central causal role in concentrating wealth and, conversely, they have failed as much as the economic system in protecting vulnerable residents from growing socioeconomic inequality in major EU cities. To test this GbRH, the Principal Investigator (PI) and his team address the main forms of urban inequality from a law and economics perspective. HABITAT measures the impact of laws and judicial decisions that, by hypothesis, have triggered urban inequalities. European urban legal systems made middle and bottom deciles, underprivileged minorities, migrants, and women worse. HABITAT tests this GbRH through a case study approach, considering Berlin, London, Milan, and Paris. The PI proposes unprecedented and unique legal research, grounded on rigorous data analysis and a robust, cutting-edge methodology that combines: a) the evolutionary analysis of legal orders, with a focus on the legal determinants of the built environment; b) the comparative analysis of the common core of urban legal systems; c) a regulatory impact assessment through econometrics, statistics, and data analysis; d) an evidence- and process- based normative model, for the design of just cities from a legal and conceptual perspective, tested through scenario analysis.

Keywords: urban inequality socioeconomic inequality legal systems law and economics
Housing, Inequality, and Price-Setting: Theory, Evidence, and Ramifications for the Macroeconomy (HIPSTERMacro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1504353.0
EU funding (EUR): 1504353.0
Participants: 1
Project status: SIGNED

This project will develop macroeconomic models with household and firm heterogeneity to investigate the importance of housing, inequality, and price-setting in macroeconomic fluctuations and the transmission and efficacy of policy. The objective is to provide a modeling framework that is consistent with both empirical microeconomic evidence on household and firm behavior and macro evidence on the response of the aggregate economy to economic shocks. A central theme will be on non-linearities and large shocks. Computational methods for solving heterogeneous agent models non-linearly in the sequence space will be developed. The ultimate goal is to help make these models the new standard for the study of fluctuations and policy evaluation in macro. Inequality and incomplete markets will be a central theme. The first objective is to quantify how changes in monetary policy redistribute resources across households and demographic groups, including gender, race, and ethnicity. The project will also focus on the price-setting behavior of firms by studying state-dependent pricing models. It will show how shifts in nominal demand can lead to shifts in the New Keynesian Phillips Curve. Next, the project will study monetary and fiscal policy in a high-inflation environment when incomplete markets and state-dependent pricing interact. The project will also focus on housing and mortgage debt as an amplification and propagation mechanism. The project will develop a rich benchmark model of housing for policy evaluation. First, the project will investigate how housing and debt heterogeneity affect monetary policy transmission. Next, the state-dependent pricing model will be integrated into the housing model to perform a cross-country analysis to quantify the importance of different arrangements in the mortgage market for the economy's response to the inflationary episode post-COVID pandemic.

Keywords: heterogeneity,incomplete markets,housing,inequality,monetary policy,fiscal policy,phillips curve
Business strategy of nanofluidic chips for next-generation bioanalysis solutions to develop future medicines (Envue)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Sweden
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-04-30
Duration (months): 10.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Envue Technologies is a Swedish deep-tech spin-out developing next-generation optical microscopy technology to achieve a deeper understanding of the building blocks of life - biomolecules such as proteins, DNA and RNA. Using a state-of-the-art combination of nanotechnology, light, and data analysis, we are at the forefront of studying single biological nanoobjects that are fundamental in life science segments such as drug discovery and development. Our patent-pending innovation, Nanofluidic Scattering Microscopy (NSM), enables a unique ability to visualize and analyze biomolecules in their native and natural state, without making any modifications to them to improve the efficiency and precision of future drugs. The core of our NSM solution is to use nanochannels in our fluidic chips as tiny optical sensors. The objectives of this proposal are to evaluate and develop our (i) production process, (ii) business model, and (iii) IP protection related to our nanofluidic NSM chips and to define the best business track and strategy for the company. This is accomplished by evaluating three options for nanofabricating the chips, establishing a maximum volume in-house production process, conducting a market analysis to understand stakeholders, conducting a patent search, and an FTO analysis related to the design and/or the function of the chips. Our goal is to commercialize NSM for a global audience, which requires long and expensive R&D processes with technical expertise. This project will therefore provide the resources and support for the next essential step in our innovation development, to significantly strengthen our position towards investors and to prepare the first round of investments to further develop and grow the company.

Keywords: bioanalytics,biopharma,life science,nanotechnology,pharmaceutical,science
Conserved develoPmentaL trAjectories chaNnelling laTeral root prImorDium morphogenesis (PLANTID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Switzerland,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 308746.56
EU funding (EUR): 308746.56
Participants: 3
Project status: SIGNED

The root system anchors the plant to the ground and absorbs water and nutrients to sustain plant development. Understanding root development and its adaptative behaviours to changing environments is a major goal of the 21st century. This interdisciplinary project aims to identify a conserved developmental program between a non-domesticated model plant, Brachypodium, and a cultivated legume crop, Lupin. Secondary root formations such as lateral root (LR) and cluster root (CR) are significant contributors to the adaptative nature of the root system’s architecture. This work will initiate five new collaborations and reciprocal expertise transfers that will benefit both the host labs and the researcher. Preliminary results from the hosting labs showed that Brachypodium LR and Lupin CR organogenesis share common developmental stages. The objectives of PLANTID are (i) investigating the developmental trajectories of LR cells in Brachypodium and (ii) identifying key cell wall (CW) regulators required for LR/CR development in Brachypodium and Lupin. The first phase of PLANTID will be conducted in the Laboratory of Cell and Molecular Biology at the University of Neuchâtel (CH) and the second phase at the IPSiM (Institut for Plant Sciences of Montpellier), Montpellier (FR). The two research labs have complementary experiences in the root development of those organisms. Secondment at MPIMP Laboratory in Potsdam will generate the first CW atlas in LR morphogenesis for the two species. I will lead this fellowship with my strong expertise in CW biology and LR development. I will identify genetic regulators that impact nutrients and water uptake with a high potential for agricultural applications in cereal species (e.g biofuel and crop productivity). The project objectives support the strategic plan for research and innovation in the Horizon EU 2021-24 and the EU Green Deal: Restoring EU’s ecosystems and biodiversity to manage sustainable agriculture (Cluster 6).

Keywords: brachypodium distachyon lupinus albus secondary root morphogenesis spatial accommodation mechanisms conserved genetic regulators cell wall atlas lateral root specific single nuclei rnaseq