Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Red-Med Marine Bioinvasion (REDMEDINV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Biological invasions constitute a major global threat to indigenous communities. Marine ecosystems are particularly vulnerable as organisms can spread rapidly and are harder to detect. The invasion of Red Sea species into the Mediterranean Sea is among the most extensively documented marine bioinvasion phenomena. The proximity of the Red Sea tropical environment and the Israeli Mediterranean rocky shore, together with the opening of the Suez Canal, present a unique geographic advantage for studying marine bioinvasion along the coasts of Israel. Comparative studies of introduced organisms from ecological, physiological, and genetic aspects can be performed readily in their native and introduced ranges. The proposed project aims to I) develop an early detection monitoring system for sessile introduced species in the Mediterranean and Red Sea, II) develop models of the dispersal patterns of non-indigenous species based on field and experimental data investigating the salinity and temperature thresholds of introduced species, and III) enhance regional sharing of information by establishing a database of marine introduced species, and by contributing scientific data to open-access databases such as The World Register of Marine Species and the Open Biogeographic Information System. Voucher specimens for future molecular and morphological work will be made available to the public. Ascidians (Phylum: Chordata) form the focus of the project due to their increasing role in altering biodiversity in fouling communities around the world, and the global rapid spread of non-indigenous ascidians. The results of this project will provide essential information to develop strategies by which to manage biological invasions in coastal marine environments, and will produce a solid essential base from which to embark on future studies on marine bioinvasion in the region.

Keywords: v306 environmental and marine biology,v305 ecology
The spatiotemporal organization of T cell signaling as a regulator of T cell function (T CELL SIGNALING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Understanding how cellular activation occurs in complex signaling networks is an important challenge in particular in multi-genic diseases such as autoimmune disease, type II diabetes, and cancer. A critical component of signaling complexity is that proteins inside live cells enrich at particular locations and times. Co-enrichment of two proteins enhances their interaction efficiency. At the systems scale, such patterning thus determines how regulatory information flows through signaling networks. We have developed approaches to harness the regulatory information encoded in systems scale spatiotemporal distributions to understand cell function, using live cell time-lapse fluorescence microscopy in imaging of the activation of primary T cells (> 50 signaling intermediates, > 10,000 cell couples). Upon transfer to the University of Bristol, we will further develop these unique approaches and apply them to understand T cell function in health and disease with two objectives. The first, methodological objective is to further develop quantitative systems scale imaging approaches, including computational image analysis and mathematical modeling, resulting in generally applicable tools for the analysis of complex signaling systems. The second, biological objective is to elucidate how the spatiotemporal organization of T cell signaling regulates lymphocyte function. By causally linking the spatiotemporal organization of signaling to cell function, we will investigate roles of the tyrosine kinases Itk and Tec as established regulators of the spatiotemporal organization of T cell signaling (Singleton et al., Sci. Signal., 2011) in cytokine secretion, primary immunodeficiency, and Leishmania infection, T cell actin regulation by the central costimulatory receptor CD28, signaling in the killing of virally-infected and tumor target cells by cytotoxic T cells and natural killer cells, and SLAM receptors in susceptibility to the autoimmune disease systemic lupus erythematosus.

Keywords: l308 signal transduction,l604 immunosignalling,l213 systems biology,l301 morphology and functional imaging of cells
WoodWisdom-Net+ Pacing Innovation in the Forest-Based Sector (WOODWISDOM-NET+)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Partnership: WOODWISDOM-NET+ (ERA-NET)
Countries involved: Finland,Sweden,Sweden,Norway,Germany,France,France,Latvia,Latvia,Austria,Switzerland,Slovenia,United Kingdom,Ireland,Slovakia
Call:  (FP7-ERANET-2012-RTD, 2012)
Start date: 2012-11-15
End date: 2017-11-14
Duration (months): 60.0
Total project cost (EUR): 23026658.0
EU funding (EUR): 7598797.0
Participants: 20
Project status: CLOSED

The overall objective of the WoodWisdom-Net+ is to support the transformation of the European F-BI and sustainable forest management for increasing resource efficiency and adapting to and mitigating climate change effects. This will be achieved by integrating knowledge and technologies of large-scale industrial products and processes, as well as primary production. The aim is to plan a single joint call for proposals for research, development and innovation in the forest sector with a clear financial commitment from the participating national (or regional) research programmes and the EU. The estimated total funding volume of the joint call is expected to ca. 30 MEUR (share of industry funding 5-10 MEUR). The main approach in the WW-Net+ is the substitution of non-renewable resources (e.g. materials or fossil fuels), by renewable forest-based solutions to reduce carbon emissions and waste. The joint trans-national call will address the whole forest-based value chain in four areas. These are: 1) the sustainable management of forest resources through 2) their efficient utilisation in industrial processes to 3) value added products and 4) competitive customer solutions. The exact scope will be defined during the project. WW-Net+ will base its research, development and innovation funding activities on the processes and experience developed during the preceding ERA-Nets towards streamlined and efficient processes. The preceding ERA-Nets WoodWisdom-Net (2004-08) and WoodWisdom-Net 2 (2009-12) form the transnational WoodWisdom-Net Research Programme (total funding volume of the launched 3 calls ca. 50 MEUR) which provides the planned ERA-NET Plus Action with a solid foundation. Looking to the future, the WW-Net+ will continue to improve the delivery of joint activities and has ambitious goals for funding trans-national research and offering access to the resources of other countries.

Keywords: wood,forest,forestry
LNG-BC: Liquefied Natural Gas Blue Corridors (LNG BLUE CORRIDORS)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Spain,Italy,Croatia,Italy,Spain,France,Germany,France,Belgium,Sweden,Netherlands,Portugal,Belgium,Slovenia,Germany,Belgium,United Kingdom,United Kingdom,Spain,Spain,Spain,Sweden
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 14500143.86
EU funding (EUR): 7962696.4
Participants: 67
Project status: CLOSED

LNG Blue Corridors unites/mobilizes the critical mass of experience (know-how, expertise, (industrial) parties and stakeholders) in LNG transport and infrastructure technology. It involves cooperation between heavy duty vehicle manufacturers, fuel suppliers, fuel distributors and fleet operators. The project includes a first definition of European LNG Blue Corridors, with strategic LNG refuelling points in order to guarantee LNG availability for road transport in a simple and cost effective way. The core of the project is the roll out and demonstration of the first stage of the roadmap of four LNG Blue Corridors involves the building of approx. 13 new LNG or L-CNG stations on critical points/locations in the Blue Corridors and the building up of a fleet of approx. 100 LNG Heavy Duty Vehicles and/or DF vehicles operating along the corridors. The project that is scheduled for 5 years has the ambition to connect over 12 Member States, to align to existing demonstrations running at national level, and to improve the knowledge and general awareness of LNG as alternative fuel for medium and long distance road transport.

Keywords: demonstration of heavy duty vehicles running wiht liquefied methane. blue corridors. lng. liquied natural gas.
Characterising the role of mammalian Target Of Rapamcyin Complex 1 (mTORC1)/Srebp1c signaling in directing the differentiation and function of T lymphocytes (SREBP1C_FN_CTL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Modulating immune responses by shifting the balance of effector versus regulatory/memory T cells has significant potential as therapy for various autoimmune diseases and preventing organ transplant rejection. The mammalian Target Of Rapamycin Complex 1 (mTORC1) has diverse effects in T cells and can function to direct T cell fate. Direct mTORC1 inhibition provides potent immunosuppression but is associated with significant toxicity. Dissecting the mechanisms that account for the multiple mTORC1 effects on T cell differentiation is required to develop targeted therapies that provide desirable immunomodulatory effects without the toxicity associated with rapamycin treatment. The function of activated T cells is closely linked to their elevated metabolic state. Thus, inhibition of T cell metabolism via disruption of glucose metabolism or amino acid availability can alter T cell function. mTORC1 activity is acutely sensitive to the metabolic cues and has established roles in regulating cellular metabolism in other systems, through the control of Hypoxia Inducible Factor 1α (HIF1α) and Sterol Response Element Binding Protein 1c (Srebp1c) transcriptional activity. Based on the hypothesis that mTORC1 integrates the control of T cell metabolism and differentiation via common pathways, our data reveals a dual role for mTORC1/HIF1α in controlling glucose metabolism and CD8 T cell function. Lipid metabolism, controlled by mTORC1/Srebp1c in other cellular systems, has also been linked to T cell differentiation. Preliminary results demonstrate that activated T cells contain active mTORC1/Srebp1c signaling and suggest mTORC1 activity controls Srebp1c target genes, supporting a potential role for mTORC1/Srebp1c in the control of T cell function. This project aims to characterize the role for mTORC1/Srebp1c in the activation, differentiation and function of T lymphocytes using complementary pharmacological and genetic approaches and using state of the art in vivo technologies.

Keywords: l405 metabolism,l605 immunological memory and tolerance,l308 signal transduction,l602 adaptive immunity,t lymphocytes,mtorc1,srebp1c,autoimmunity,organ transplant.
Strategic high-level transport model (HIGH-TOOL)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: HORIZONTAL ACTIVITIES for implementation of the TRANSPORT PROGRAMME
Action type: Coordination and support actions
Countries involved: Germany,Spain,Netherlands,Netherlands,Belgium,Hungary
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-04-15
End date: 2016-08-14
Duration (months): 40.0
Total project cost (EUR): 3294849.4
EU funding (EUR): 2499060.64
Participants: 8
Project status: CLOSED

The HIGH-TOOL project aims at developing a free and open high-level strategic transport model to assess economic, social and environmental impacts of transport policy. The HIGH-TOOL model will allow quick scanning of transport policy options by the European Commission (EC). Input and output indicators of the model will be based on policy targets of the White Paper 2011 and the Roadmap for moving to a low-carbon economy in 2050, but may also be relevant to other areas of transport policy. The EC’s Impact Assessment Guidelines will serve as an important reference to define the model’s output variables. The HIGH-TOOL model will be largely based on equations and elasticity developed in previous or ongoing research projects. The model will serve as a pre-selection tool of policy options that will be further evaluated by more detailed models such as TRANSTOOLS and TREMOVE. High attention will be attached to obtain consistency between HIGH-TOOL and the EU Reference Scenario 2013. The model will be introduced successively during the project in order to facilitate the participation of potential users: The prototype version will be provided at an early stage, and will be largely based on existing and previous meta-models such as EXPEDITE, SUMMA or TRANSVISIONS. This prototype will be extended continuously by substituting and/ or refining the modelling formulation and adding further functionalities. This evolution process will be carried out under involvement of users, and under consideration of results from testing and validation processes. The development of the model will be accompanied by a Scientific Advisory Board, assembling distinguished experts that represent model users and model developers. The HIGH-TOOL model will provide a web interface allowing users to assess policy options via the Internet. A carefully elaborated, reader-friendly User Guide and the organisation of a User Training Course will complement the provision of the HIGH-TOOL model.

Keywords: transport,transport model,transport policy,transport planning
Structural biology of Legionella’s effectors and secretion system (STRUCT4LEG)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 2475317.2
EU funding (EUR): 2475317.2
Participants: 1
Project status: CLOSED

Legionella pneumophila is the causative agent of a severe form of pneumonia known as Legionnaires’ disease. Legionella utilizes a type IV secretion system, encoded by the dot/icm gene cluster, to secrete circa 300 effectors that highjack host cellular function to allow the bacterium to live intracellularly inside macrophages. Although the molecular basis of effector function has been elucidated for a small number of effectors, there remain a large number of effectors for which no function has been ascribed. Moreover, when function is known, the host target to which the effector binds has not always been identified. Finally, when effector function and target are known, the molecular basis of effector-target interaction often remains to be determined. This proposal aims to address these issues using a structural biology approach. Another issue addressed by this proposal is the structural and molecular characterisation of the Dot/Icm type IV secretion system responsible for effector secretion through the double membrane of Legionella. Therefore, we propose here three complementary lines of research: i- using a structural biology approach, we will determine the structures of functionally-uncharacterised Legionella effectors in order to derive their function; any function derived from structure will be validated by Professor Craig Roy, a leading researcher in the field of Legionella infection. ii- when/once the effector’s target is known, we will investigate the molecular basis of effector-target interaction by determining the structure of the binary effector-target complexes. iii- we will investigate the structure of the secretion apparatus that is responsible for secreting effectors through the Legionnella membrane. This proposal will greatly enhance our knowledge of the various mechanisms used by pathogenic bacteria to develop intra-cellularly in humans, and provide the basis for drug design efforts aiming at neutralizing Legionella infection.

Keywords: bacterial pathogenesis,legionella,secretion system,effector
The role of viral photosynthetic proteins in oceanic photosynthesis (PHOTOPHAGE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: Israel
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 1933800.0
EU funding (EUR): 1933800.0
Participants: 1
Project status: CLOSED

Cyanobacteria play a key role in marine photosynthesis, contributing almost 50% of primary production in oligotrophic regions of the ocean. Marine cyanophages were recently discovered to carry photosystem II (PSII) genes, and it was suggested that these genes increase phage fitness by helping the phages to maintain photosynthesis in the infected bacterial cells. We recently showed evidence for the presence of photosystem I (PSI) genes in genomes of marine cyanophages [Sharon et al. 2009 Nature 461, 258-262]. Cyanobacterial core PSI gene cassettes, containing psaJFABCDEK, or psaDCAB gene cassettes forms unique clusters in cyanophage genomes, suggestive of selection for a distinct function in virus reproduction. Potentially, the proteins encoded by the viral genes are sufficient for forming intact monomeric PSI complexes. Projection of viral predicted peptides on the cyanobacterial PSI crystal structure suggests that the viral PSI components provide a unique way for funneling reducing power from respiratory and other electron transfer chains to PSI, therefore bypassing the need to rely solely on reducing power from the photosystem electron transfer chain. The main goals of this proposal are: (1) To determine how much of oceanic photosynthesis is actually performed with viral proteins. (2) To establish a model system to understand the role of modified photosynthetic viral proteins in photosynthesis We hypothesize that viral photosynthetic peptides are integrated into the bacterial photosynthetic membranes in order to maintain photosynthesis in infected cells, that otherwise stop to photosynthesize, and that changes are introduced to the system as a whole. The proposed research will integrate concepts and techniques from metagenomics, metaproteomics and bioinformatics techniques to explore the interaction of viral PSII and PSI proteins with their host reaction center complexes, and to examine their influence on global marine photosynthesis production

Keywords: phages,viruses,photosynthesis,cyanobacteria
Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of Biological Interest (ANION_CAGES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient synthetic receptors for anionic entities in aqueous solution have attracted lesser attention than ligands for cationic or neutral species. The intrinsic physicochemical problems of anion binding and the molecular diversity of anionic species have often hampered this research field. In this project, the identification and synthesis of new molecular receptors for anions with biological relevance is proposed. To this aim, we will use a constitutional dynamic chemistry approach, a conceptually new methodology based on the molecular evolution idea. Thus, we will prepare a dynamic library of components interconnected through exchange by chemical equilibriums. These building blocks will bear a molecular recognition moiety able to bind anions, and the required functional group(s) for the establishment of a covalent bond under reversible conditions. In the presence of the target entity (an anionic template), the dynamic system will evolve to efficiently interact with the template and the best binder will be amplified and identified. As the building blocks, we will use peptide-like molecular architectures, since they can bear different potential anion binding functions (amide, ammonium, etc…), show large molecular and structural diversity and, in general, display good biological tolerance. Additionally, their synthetic, isolation and characterization procedures are quite straightforward. Using this rationale with anionic templates of biological importance, this methodology will allow us to synthesize new receptors of biologically interesting molecules with increased binding abilities, which will be finally tested for the corresponding biological functions. Therefore, if successful, this project will mean an important methodological breakthrough in anion recognition chemistry.

Keywords: c102 nanochemistry,c104 molecular architecture and structure,c110 combinatorial chemistry,c140 supramolecular chemistry,c141 organic chemistry