Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SUSTAINABLE ENERGY HARVESTING SYSTEMS BASED ON INNOVATIVE MINE WASTE RECYCLING (START)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Portugal,Spain,Germany,Belgium,Poland,Italy,Netherlands,Slovakia,Norway,Denmark,Austria
Call: Building innovative value chains from raw materials to sustainable products (IA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 9194441.25
EU funding (EUR): 7667878.0
Participants: 17
Project status: SIGNED

START project primary objective is to build an innovation ecosystem in the European Union (EU) based on the development of sustainable and economically viable thermoelectric (TE) waste heat harvesting systems to be applied in heavy industry and in maritime industry as well as primary power source for off-grid sensors and IoT devices. This objective will be achieved by incorporating abundant sulphides (mainly tetrahedrite mineral series), at present an environment hazard in mine tailings, collected in five European countries, in the production of advanced sulphide p-type TE thermoelements. In contrast, current commercial TE devices incorporate p-type and n-type TE thermoelements that are produced from expensive and rare elements, namely tellurium, which is predominantly sourced in China. The impact of START project approach on endorsing a more sustainable and resilient EU comes from three inputs. First, by reducing EU?s dependence on primary critical raw materials. Secondly, through the promotion of circular economy processes that will create value in EU by building a strategic ecosystem based on a high-abundant mineral. Just recently, it was demonstrated by our team that the mineral was amenable to processing to single phase p-type tetrahedrite. Thirdly, by the production of TE energy harvesting systems offering a contribution to the reduction of fossil fuels consumption with a great impact on the increase of the overall efficiency of energy production and consumption systems, as well as on the reduction of the greenhouse gas emissions. For that, START project aggregates research organizations, with strong background and knowledge on geology, materials science and renewable energies, and industrial organizations that guarantee the entire production and exploitation supply chain.

Keywords: secondary raw materials,circular economy,tellurium free thermoelectric devices,mine wastes recycling
Enhancing Social Stability and Cohesion to Reduce Conflict Risks in the MENA Region (AMIN_MENA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Jordan,United Kingdom,Lebanon
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-07-31
Duration (months): 35.0
Total project cost (EUR): 302052.2
EU funding (EUR): 302052.2
Participants: 4
Project status: SIGNED

The project has the overall objective to provide a broader understanding of conflict dynamics in Jordan and Lebanon and improve international organizations and EU programming on social cohesion and stability reducing the risks of internal social conflict outbreak in these countries. The action aims at assessing social cohesion in Jordan and social stability in Lebanon, by exploring internal conflict dynamics and identifying similar patterns and systematic differences. Moreover, it has the goal to identify concrete measures to increase social cohesion and stability in Lebanon and Jordan to reduce the risk of internal social conflict. Given the current state of affairs in the MENA region, the relevance and urgency of this study are paramount in terms of both timing and scope. This project is intended to provide crucial insights pertaining to social cohesion and stability to the EU for its external endeavors in the Middle East, with a particular emphasis on Jordan and Lebanon. This research not only addresses the existing gap in literature but also explores two case studies from both a top-down and bottom-up approach. It will employ a mixed-method methodology, with a significant focus on Participatory Action Research to ensure the inclusion of key stakeholder viewpoints in the research findings.

Keywords: eu external action participatory action research social cohesion and stability
Understanding outer membrane protein biogenesis in Bacteroidota bacteria (BactOMPbuild)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 2490791.75
EU funding (EUR): 2490791.75
Participants: 1
Project status: SIGNED

Gram-negative bacteria are distinguished by the presence of an outer membrane (OM) at the cell periphery. This membrane is the site at which the bacterium interacts with its environment (or host if a pathogen), and provides the first line of defence against antibiotics, mechanical stresses, and immunological attacks. These functions depend on the presence of proteins that either span the outer membrane (Outer Membrane Proteins, or OMPs) or are anchored to the membrane by a lipid tail (lipoproteins). Sophisticated machinery is required to target, insert, and fold these proteins. Although this machinery is well-characterised in Escherichia coli and related organisms, it remains unclear how OM proteins are assembled in other major Gram-negative phyla. In this project we aim to elucidate novel features of OM protein biogenesis in bacteria of the phylum Bacteroidota (formerly Bacteroidetes). The Bacteriodota are key human commensals, but also include major anaerobic pathogens, and are environmentally abundant. The pathways for OM protein biogenesis in the Bacteroidota differ from the E. coli paradigm in at least two major ways that we will investigate. First, we have discovered that the Bam complex that is responsible for inserting OMPs into the OM has a very different composition from the E. coli paradigm and includes novel extracellular subunits. We now seek to identify the function(s) of these additional subunits and elucidate their molecular mechanism. Second, in contrast to E. coli, the cell surface of Bacteroidota bacteria is coated with abundant lipoproteins (surface lipoproteins, or SLPs) that must be exported across the OM by a currently unknown mechanism. We aim to identify and characterise this SLP transporter as well as the novel pathway that our work has shown is needed for delivering SLPs to the OM. To carry out these tasks we will employ in vivo and in vitro protein biochemistry, bacterial genetics, and structural analysis by cryoEM.

Keywords: bacterial outer membrane,periplasm,bacteroidota,bacteroidetes,bam complex,surface lipoprotein biogenesis,bacteria,membrane protein biogenesis,protein transport,periplasmic chaperones,skp,tam,omp85 family
VALorisarion of fUngAl Biomass using noveL Enzymatic technology (VALUABLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Germany,Norway,Greece,Spain
Call: Novel, non-plant biomass feedstocks for industrial applications (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 6964868.25
EU funding (EUR): 5972375.03
Participants: 9
Project status: SIGNED

Biomass is at the core of the bioeconomy and the demand for it is increasing worldwide as we transition to a low-carbon economy. Biomass is predominantly used for feed and food products (~55% of global biomass available) followed by bioenergy, with only 8% to date used for bio-based materials despite offering an alternative to fossil-derived chemicals. To promote the development and commercialisation of bio-based materials, an abundance of feedstocks (i.e., sugar, starch, vegetable oil and ethanol) are required. However, this may lead to biodiversity and land use change as potentially more land would be needed to enable the replacement of fossil raw materials, estimated at an additional 2.8 billion tonnes (Bt) Dry Matter (DM) biomass per year, which competes with food and feed production. To achieve a sizeable and economically feasible bioeconomy, new technologies are therefore needed in order to diversify and deliver processes that can use available, underutilised and more sustainable biomass feedstocks to leave more land available for biodiversity protection and food production, whilst facilitating the substitution of fossil-based resources with bio-based ones. VALUABLE will focus on the demonstration of a platform non-plant-based biomass valorisation process for the production of yeast oils as a viable substitute for fossil-based and plant-based products (such as palm oil) in applications such as cosmetics, adhesives and resins. More specifically, the VALUABLE process will valorise Aspergillus niger biomass feedstock to demonstrate: 1. Techno-economic viability of producing oils as a substitute for fossil based and plant-based products for applications in cosmetics and bio-based chemicals (e.g., resins for coatings) markets. 2. Better valorisation of fungal biomass waste streams rich in chitin for the production of non-animal derived chitosan and chitosan oligomers for use in applications such as cosmetics and bio-based chemicals (e.g., adhesives) markets.

Keywords: biomass,fungi,upcycling,cascading use,valorisation,
RESTORING CARDIAC CONDUCTIVITY IN ATRIAL FIBRILLATION AND LEFT BUNDLE BRANCH BLOCKS WITH NOBLE METAL-BASED NANO-BIOMATERIALS (NANOBEAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Germany,Netherlands,Austria,Ireland,Belgium
Call: Advanced biomaterials for the Health Care (IA) (HORIZON-CL4-2024-RESILIENCE-01-TWO-STAGE, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 7288095.79
EU funding (EUR): 6664937.47
Participants: 8
Project status: SIGNED

The NANOBEAT consortium is focused on addressing the significant issue of impaired cardiac conductivity and its associated cardiac arrhythmias in the European Union. These conditions affect around 13-22 million people in the European Union alone. Two of the most important arrhythmias in this context are Atrial Fibrillation (AF) and Left Bundle Branch Blocks (LBBB The debilitating consequences of LBBB and AF include stroke, HF, and death and also contribute greater than 2.6% of the annual healthcare expenditure in the EU. Currently available therapies for AF and LBBB have limited effectiveness, with efficacy rates ranging from 35-60% in patients. These therapies are also associated with low biocompatibility and require costly follow-up treatment. The NANOBEAT consortium aims to develop a new medical device called CardioINK - a composite biomaterial composed of noble metal-based nanowires in a collagen-alginate hydrogel delivered to damaged cardiac tissue using specialized minimally invasive catheters. The nanowires self-assemble in the damaged areas, restoring cardiac signaling conductivity and resolving the negative effects of AF and LBBB. Preliminary results from porcine animal models treated with CardioINK have shown 100% efficacy in diminishing the negative effects of LBBB and AF. The ultimate goal of the consortium is to ready CardioINK for first-in-human trials by project end. NANOBEAT will also develop a commercialization and regulatory strategy to introduce CardioINK to both the EU and US markets. Recognizing the importance of including the patient perspective in the development process, NANOBEAT will establish patient advisory boards to ensure that the patient voice and needs are integrated into the development of CardioINK in all stages. Overall, the NANOBEAT consortium's efforts to develop CardioINK have the potential to revolutionize treatment options for individuals with impaired cardiac conductivity and significantly improve patient outcomes.

Keywords: cardiology biomaterial atrial fibrillation left branch bundle block medical device biomaterial nanowires,
Growing Long Distance - RNA Control of Neuronal Extension (GrowthSINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Neurons are the longest cells, extending axons over distances that can reach four orders of magnitude larger than their cell body diameters. How can they achieve such long distance growth? After initial engagement with target cells, neurons undergo stretch-induced elongation as the nervous system matures with the growth of the organism. The molecular mechanisms enabling such prodigious growth are unknown. Based on strong preliminary evidence, we tested the hypothesis that both the initial elongating and later stretch-induced axon growth act via a shared RNA localization mechanism. Very strikingly, we identified a specific subset of polyadenylated repeat element RNAs, hereby termed growth-inducing SINEs (GI-SINEs), as key growth regulators. GI-SINEs are induced from AP-1 promoter-associated extragenic loci, and interact with ribosomal proteins and the axon growth regulating RNA binding protein nucleolin, in neuronal cytoplasm. We will elucidate how this intrinsic mechanism controls neuron growth, determining (1) how known elongating growth regulators affect stretch-induced growth; (2) how local and global protein synthesis regulate neuron growth control; and (3) how growth regulates the GI-SINEs and how they regulate different growth modalities. We will apply a multidisciplinary suite of techniques and approaches to these challenges, including a new technology for characterization of nascent proteomes developed in-house. The proposed project will provide ground-breaking and fundamental mechanistic insights on neuronal growth, and will establish novel methods that will be widely applicable. Moreover, establishing that a repeat element RNA is an intrinsic effector linking AP-1 transcription to translation regulation is a breakthrough finding that opens new horizons for cell biology and neuroscience.

Keywords: axon growth,axonal transport,rna localization,local translation,neuronal length sensing
Bayesian tools for one-dimensional and three-dimensional hadron structure (Bayhadron)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Parton Distribution Functions (PDFs) and Transverse-Momentum-Dependent PDFs (TMDs) encode our knowledge of the nucleon internal structure in terms of their elementary constituents, quarks and gluons. They are determined by means of global analyses of experimental data which require the development of suitable fitting methodologies. PDFs and TMDs represent an important input for precision studies at current and future accelerator facilities. The development of reliable fitting methodologies and their subsequent validation, in order to ensure the soundness of the corresponding results, is therefore a crucial problem in high-energy physics. Thanks to the wealth of new data and fitting methodologies, the accuracy to which PDFs and TMDs are known is rapidly improving. With the reduction of the uncertainties, an increasing tension has been observed among results from different groups, making the discussion around the determination of faithful uncertainties all the more urgent. This research proposal, Bayesian tools for one-dimensional and three-dimensional hadron structure (Bayhadron), develops a new methodology based on Bayesian inference and a set of statistical validation tools for PDF and TMD determination. The main goals of Bayhadron are two. 1) The development of a fully Bayesian methodology for PDF determination, providing a valid alternative to the methodologies based on parametric regression currently used within the community, and the release of a first PDF set based on it. 2) The application of validation tools developed within the PDF community to validate the fitting methodologies currently used for TMD determinations and their possible improvement by means of a Bayesian approach. Both goals of Bayhadron concur to a faithful determination of PDF and TMD errors, introducing a set of innovative statistical tools in the field and making the proposal particularly timely in light of current and future experimental and phenomenological efforts.

Keywords: parton distribution functions,transverse momentum dependent functions,global fits,gaussian processes,bayesian inference
UPscaling WIND turbines using digital twins technologies. Repowering design, validation and monitoring. (UPWIND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 181423.68
EU funding (EUR): 181423.68
Participants: 2
Project status: SIGNED

Clean energy production needs to expand in order for Europe to achieve its net-zero emission goals of 2050. UPWIND aims at the “massive” and “rapid” upscaling of the current onshore wind turbine stock in order to address the highly challenging sustainable energy targets and mitigate climate crisis. 38GW of existing onshore wind structures will reach their end-of-life in Europe by 2025 and new wind farms typically take about 13 years from concept to operation. Upscaling existing structures is the only reliable strategy to immediately increase wind energy installations as it can double generation capacity (in MW) of existing onshore wind farms within a very short period. UPWIND aims to develop an innovative machine learning-assisted upscaling framework for existing onshore wind structures to be converted to new-age powerful ones. This will be achieved by replacing old turbines with more efficient and powerful new-age turbines, increasing the height of the existing onshore tubular steel wind turbine towers, enhancing the load-bearing capacity of the towers and by extending their operational life. The research output of UPWIND will enable decision-making for innovative repowering strategies focusing on upscaling the existing support towers to bear the new loads (increased self-weight, fatigue vibrations) caused by heightening and new turbines installation, by selecting suitable strengthening schemes. New upscaling methods and strengthening schemes will be implemented and a new digitalized decision-making framework for repowering old wind turbine towers will be developed. UPWIND will introduce a gamechanger strategy that will directly increase energy production from wind structures, taking advantage of the already used best onshore locations and existing permissions, avoiding non-economic and non-environmental friendly total tower replacements, thus significantly contributing to a fully circular net-zero future for the european energy sector.

Keywords: steel structures,structural engineering,civil engineering,wind energy structures,wind turbine tower design,sustainable design,sustainable energy production,economical design,net zero economy
Interconnected Innovation Ecosystems – Reduce, Reuse and Rethink (3R - Connect)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Belgium,Portugal,Denmark
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 499644.0
EU funding (EUR): 499644.0
Participants: 6
Project status: CLOSED

The proposed project seeks to support the development of interconnected innovation ecosystems across the EU with a starting point in three focus regions; the Greater Copenhagen region, Flanders and Northern Portugal. To this end, the partners will apply the S3-Innovation Model for development of Transformational Actions towards a circular economy, specifically focusing on actions for Reducing, Reusing and Rethinking resources within three sectors; plastics, textiles and construction. This methodology will be employed to map and analyse regional capacities and potentials for transformation through the involvement of quadruple helix focus groups to include priorities from different actors in the innovation ecosystems. Based on these mappings, the partners will identify cross-regional actions with potential to drive circular transformation across European innovation ecosystems. To enable concrete collaborations, the partners will develop one joint cross-regional action plan for collaborative actions in each of the three focus sectors, particularly focusing on actions for ‘reusing’, ‘reducing' and ‘rethinking’ resources. To prepare the ground for future implementation of the joint action plans, the partners will focus heavily on dissemination across EU territories and capacity building for ecosystem stakeholders. Moerover, the consortium will establish dedicated virtual collaboration spaces and communities on an already existing virtual platform to convene ecosystem stakeholders around project activities concerning circularity within plastics, textiles and construction. Upon the post-project implementation of the action plans, the proposed project is expected to contribute to increased market uptake and adoption of innovative solutions through concrete actions for connecting innovators to public buyers. Moreover, the project is expected to facilitate an infrastructure which enables closer connections between research institutions and innovators.

Keywords: action plans for circular transformation,ecosystem mapping and analysis,interconnected ecosystems