Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Studying the role of Quiescent Cancer Stem Cells in GBM development using a novel in vivo cell cycle-based approach (QuiescStemGBM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Glioblastoma (GBM) is the most common and aggressive high-grade primary brain tumour in adults. More than 90% of the patients shows recurrence of the disease with a survival of 2 years despite a multitherapeutic approach consisting of a first surgical resection of the brain lesion followed by radio- and chemo-therapy. GBM patients die because of the cancer relapse that evolve becoming not sensitive to the classical therapies. A sub-population of quiescent/slow cycling cancer stem cells (CSCs) has been proposed to be the origin of the cancer relapse. The features and role of that specific population of CSCs within GBM is still not well characterised. The aim of the proposed project is to first clarify the cell cycle state of CSCs within GBM induced in mouse models in addition to their contribution and role in cancer development. To achieve this goal, I will use a cell cycle-based approach together GBM mouse models to: characterise the cell cycle state of CSCs within tumour (Aim 1); analyse the contribution of quiescent and proliferating CSCs during cancer development and their molecular features using a novel cell cycle-based lineage tracing approach (Aim 2); analyse the effect of selective ablation of each CSCs sub-subpopulation in cancer growth a novel cell cycle-based cellular ablation (Aim 3). Using a cell cycle point of view, the obtained results will be fundamental for the definition and the role of the different CSCs co-existing within glioma. In particular, the findings will open new avenue in the study of the role of quiescent or proliferating cells within GBM and give the possibility to others in the field for testing for example which cells contribute to cancer relapse after the initial tumour treatment (mass debulking and following radio- and chemo-therapy) or even design new drugs targeting specific CSC types.

Keywords: glioblastoma multiforme,mouse,cancer stem cells,quiescence,cell cycle
Supported organocatalysts and their applications in the upgrade of bioderived polyols: desymmetrisation of glycerol to obtain building blocks for fine and pharmaceutical chemicals prod (SOCUPols)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Cooperative nucleophilic-electrophilic catalysis by ionic liquids (IL) has been recognised as a powerful tool for sustainable chemical transformations. Some of these transformations proved to be suitable for biomass derived chemicals upgrade. The SOCUPols project aims at preparing novel organo-catalysts based on supported IL-like fragments for the upgrading of biomass derived polyols such as diols and glycerol. Unlike ionic liquids and other organic salts, these heterogeneous catalytic systems will be fully recyclable and suitable for continuous flow operation. Project development will focus on the overall process sustainability: (a) by developing new polymer supported catalysts for environmentally friendly transformations; (b) by using these catalysts for the selective chemical upgrading of diols and glycerol (transesterification/acetalisation reactions) using green solvents and reactants; (c) by using carbonate formation as a CO2 fixation strategy; (d) by modifying the catalytically active sites to carry out asymmetric transformations, thus achieving the desymmetrisation of glycerol towards chiral synthons for fine and pharmaceutical chemistry; (e) implementing the most promising transformations in continuous flow (CF). This approach will be used for the design of simple and feasible strategies for the exploitation of renewable biogenic resources by retaining molecular complexity of biomass-derived material to prepare added value molecules and materials. This will represent a better alternative to low oxygen containing petroleum-derived feedstocks. Through SOCUPols, Dr. Marco Noè, Experienced Researcher (ER) interested in sustainable chemistry and fine and pharmaceutical chemical synthesis, will pursue academic career development through a specific technical training and project managing expertise, integrated with complementary added-value non-scientific skills.

Keywords: sustainable chemistry,organocatalysis,ionic liquids,continuous flow,asymmetric transformations,polymer supported,glycerol,onium salt,process intensification
POLY-stakeholders for integrated CARE for chronic patients in acute phases (POLYCARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Spain,France,France,France,Portugal
Call: Advanced ICT systems and services for integrated care (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 4440652.5
EU funding (EUR): 4440651.5
Participants: 10
Project status: CLOSED

Nowadays, chronic diseases and co-morbidities have to be managed during a long period of time among health and social care systems, thus a big amount of budget and resources should be destined to them. If these patients could stay at home during their illnesses exacerbations, a big amount of resources could be saved, a more independent like and a higher quality of life for these patients could be reached due to fewer hospitalizations, more remote control of their health status by care services and by self- knowledge of their own disease. For this purpose POLYCARE will provide ICT solutions that will foster real integrated care between health and social care following a new methodology that will be defined with European focus. These ICT solutions will be based on a collaborative environment between health and social care services that will help to share information between them and a Decision Support System will provide alerts, recommendations and adverse effects due to medicaments interaction in the case of poly-medicated patients. On the other hand, we will take care of patients by providing devices and personalized apps for being involved at their self-health management and fostering interaction with medical and social care services.The project will be focused on home hospitalization (patient treatment at as in the hospital). The target patients are chronic patient in acute phases, who are usually elderly people. Thus, patients’ apps will be based on gamification basis in order to be more attractive and accessible; to measure vital signals to control their health status will be provided by optimized wearables devices so that they not need any specific knowledge. Besides, informal care givers and social professionals will support patients on these new tools and will include additional data to monitor. These innovation features will be carried out by a strong consortium headed by a company leading ICT solutions for health fostering business opportunities to all.

Keywords: integrated care,gamification,home hospitalization,chronic diseases,acute phases,wearables,self management,empowerment,methodology
Studying, Measuring and Altering Consciousness through information theory in the electrical brain (LUMINOUS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Spain,Belgium,France,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3925588.75
EU funding (EUR): 3925588.5
Participants: 8
Project status: CLOSED

What is consciousness? Can it be measured? While humankind has struggled with these questions for millennia, our project will focus on more modest but nonetheless ambitious and related goals. Inspired by recent developments in neuroscience and the potential role of fundamental concepts such as information integration and algorithmic complexity, we will study, model, quantify, and alter observable aspects of consciousness. Our vision is that consciousness will someday be electromagnetically measured and altered, and that the associated needed insights will prove crucial to the development cognitive sciences. The conceptual framework of the project rests on information theoretic developments that link consciousness to the amount of information that a physical system can represent and generate as an integrated whole, and from the related idea that consciousness can be quantified by metrics reflecting information processing and representation complexity. Supported by computational neuroscience models, we aim to create non-invasive consciousness-probing technologies integrating electro- and magneto-encephalography, peripheral and non-invasive brain stimulation (NIBS) with advanced techniques to analyse brain activity – including functional and effective connectivity. Based on the derived brain activity metrics, we will explore intervention, ie the use of NIBS to alter consciousness. To achieve these goals we will pursue computational neuroscience models and human studies – in perception, sleep, anaesthesia, locked-in syndrome, disorders of consciousness, and in utero – supported by machine learning to disentangle the essential aspects of consciousness. The project will also explore the ethical implications of such technologies and the prospects for clinical translation. If successful, this paradigm-shifting work will have profound social and clinical impact and provide key insights in fundamental neuroscience and artificial cognition research.

Keywords: consciousness theories,cognitive sciences,consciousness correlates,disorders of consciousness,sleep,anaesthesia,info theory,complexity,connectivity,weak artificial conscious
Ecology and Evolution of Prospecting Strategies (EcoEvoProspectS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Prospecting behaviours allow individuals to gather personal and social information on the local quality of potential future breeding sites and help them make dispersal and settlement decisions. As it can have multiple consequences on individual distribution, fitness and population dynamics, exploring the ecology and evolution of prospecting strategies is essential in a context of climate change. Yet, studies dealing with this topic are scarce because of methodological and technological challenges. In this project, I will develop and apply novel theoretical and statistical approaches to deliver major new insights into the adaptive, ecological and evolutionary importance of prospecting strategies in individual and population responses to environmental change. First, I will develop a spatially-explicit individual-based model to quantify the effects of local environmental conditions, life history traits and range margins on the evolution of prospecting strategies. I will also test how inter-individual variation in these strategies may help or hinder populations in responding to rapid environmental change. Second, I will extend a state-space model to robustly quantify prospecting movements from GPS tracking data. This will provide an innovative and powerful tool that will give new insights into the behavioural mechanisms involved in breeding habitat selection. Finally, I will integrate the underpinning knowledge gained from the theoretical and empirical results to add new functionality to the existing platform RangeShifter. The multidisciplinary nature of the project is strong, involving a combination of evolutionary biology, behavioural ecology, movement ecology and conservation biology. The project will open new perspectives in our fundamental understanding of breeding habitat selection and dispersal processes and will be essential to better predict and effectively manage species’ responses to climate change.

Keywords: social information use,informed dispersal,breeding habitat selection
Conversion of Low Grade Heat to Power through closed loop Reverse Electro-Dialysis (RED-Heat-to-Power)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: New knowledge and technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Germany,Netherlands,Netherlands,United Kingdom
Call: New knowledge and technologies (H2020-LCE-2014-1, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 3992402.5
EU funding (EUR): 3992402.25
Participants: 9
Project status: CLOSED

The concept is based on the generation of electricity from salinity gradient using Reverse Electrodialysis with artificial saline solutions operating in a closed-loop. The original salinity gradient is regenerated by a separation step that uses heat at 40 - 100 C. The regenerated solutions can be stored at very low costs and the stack can react within seconds, providing flexibility to the power system. It is a quiet technology operating under normal pressures and temperatures imposing no risks. The industrial partners ensures the MRL will be kept aligned with the advances in TRL. The overall objective is to prove this revolutionary concept, develop the necessary materials, components and know-how for bringing it to the level of a lab prototype generating electricity from low-grade heat at higher efficiencies and lower costs than ever achieved to date. Specific objectives: Select the most suitable technologies for the regeneration process and the combinations of salts and solvents that can maximise the system performance. Create new knowledge for developing: membranes for the selected solutions; membrane manufacturing concepts that can be scaled-up for high volume and low-cost production; efficient stacks suitable for this application; energy efficient regeneration processes. Implement and validate a process simulation tool to analyse the performance under different configurations and operating conditions. Evaluate and improve the performance of the overall system through tests on a lab-prototype, identifying potential up-scaling and operational issues (System efficiencies reaching 15% and power densities of 25 W/m2 of cell pair). Define a development roadmap, taking into account environmental, social and regulatory issues, leading to levelised cost of electricity below 0.03 Euro/kWh by 2025 to 2030. Involve target group representatives to the Advisory Board and communicate the key results in order to initiate a dialogue and facilitate the engagement of key actors.

Keywords: low grade heat,reverse electrodialysis,salinity gradient power,renewable electricity,ion exchange membranes,desalination,azeotropic mixtures,adsorption,desorption,thermolytic salts
European Consortium for Lithium-Sulfur Power for Space Environments (ECLIPSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Belgium,France,France,France,Czechia,United Kingdom,United Kingdom
Call: Bottom-up space technologies at low TRL (H2020-COMPET-2015, 2015)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 999953.75
EU funding (EUR): 999953.75
Participants: 12
Project status: CLOSED

For space missions, the energy density of batteries is a key factor of systems mass. A recent battery technology, based on this Lithium-Sulfur chemistry and developed by OXIS Energy, has shown promising results, particularly in terms of specific energy and cycling performances. Lithium-Sulfur batteries could become the next breakthrough technology for space batteries, with a factor of two on the specific energy compared to the current Lithium-Ion products. ECLIPSE ambition is to channel the research activities in Europe and, as a spinning-in effort, ensure that the harsh space constraints are taken into account for the further improvements of the Li-S technology. This research action aimed at developing Li-S technology for space applications focusing on three levels: - Cell level studies, including research to optimise the four main cells components: anode, cathode, separator and electrolyte to achieve 400Wh/kg cells compatible with space cycling profiles. - Battery and encapsulation level, including prototyping and theoretical studies. - System level studies for integration in satellite and launcher architectures, taking into account the economic constraints and the future technical challenges. The expected outcomes of ECLIPSE are: - Mass reduction of batteries by a factor two. - Costs reduction at all levels: subsystem, system and launching costs. - Maturation of the technology (TRL 5 expected at the end of the project). The main impacts of this research are related to competitiveness (lighter is cheaper), non-dependency and innovation: beyond current markets, this breakthrough can enable new challenging missions. The impact of the project is secured by the composition of the consortium led by Airbus Defence and Space with the main European actors of the Lithium-Sulfur electrochemistry and space batteries: ECLIPSE will contribute to the consolidation of an independent European industrial supply chain for Lithium-Sulfur batteries. Project duration is 24 months.

Keywords: battery,electrochemistry,lithium sulfur,space systems,satellite,launcher,lifetime,energy density
International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley (IberusTalent)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 5650560.0
EU funding (EUR): 2825280.0
Participants: 1
Project status: SIGNED

International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley (IberusTalent) is a step forward from the Campus Iberus aimed at boosting the R&I capacity and high quality human resources of the University in the field of Agrofood and Health technologies. IberusTalent is a Doctoral Programme for Early Stage Researchers (ESRs) aimed at attracting 36 pre-doctoral excellent researchers to develop individual and freely selected project in the field of Agrofood and Health Technologies in order to produce a positive effect in terms of excellent science and talent attraction, especially at the regional level. IberusTalent will offer attractive conditions for doctoral training based on the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers, as well as the EU Principles for Innovative Doctorate Training. The IberusTalent Programme will be based on the scientific and technological capabilities of the four Recruiting Universities (UdL, UPNA, UR & UNIZAR) within Agrofood and Technologies for Health, and the participation of their excellent research groups with investigation lines related to these areas. Additionally, the involvement of international Universities and non-academic participating organisations (companies, research centres and hospitals) with strong expertise on the Programme specific areas will guarantee attractive ecosystem for incoming researchers by offering secondments, short stays, and training at industry.

Keywords: talent attraction,campus of international excellence,campus iberus,doctoral programme,phd programme,health tech,agrifood,health technologies
Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles (OBSERVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

RNA-based therapeutics, including siRNA, miRNA, mRNA and CRISPR/Cas9 components, have unprecedented therapeutic potential and hold the promise of treating any disease with a genetic component. However, inefficient delivery into diseased cells hinders their clinical progress. Consequently, there is an urgent need for novel, original approaches to overcome the delivery challenges. Recently, an endogenous RNA transport system has emerged, based on the release and uptake of extracellular vesicles (EVs). EVs are naturally equipped to transfer RNA molecules to other cells in a functional and selective manner. Furthermore, I have recently demonstrated that EVs deliver RNA more efficiently than state-of-the-art synthetic RNA nanocarriers. Thus, EVs hold promise as a new paradigm for RNA delivery. However, the mechanisms underlying EV-mediated RNA transfer are unknown, and reproducible methods for efficient loading of EVs with therapeutic RNA are lacking. The aim of my proposal is to (1) elucidate the mechanisms underlying EV internalization and processing that lead to the functional delivery of their RNA content and (2) radically improve the loading efficiency of EVs for therapeutic RNA delivery. To realize this, I will: 1) Identify genes and pathways involved in EV-mediated RNA transfer using a novel CRISPR/Cas9-based RNA delivery reporter system. 2) Systematically compare uptake and intracellular trafficking of EVs and synthetic nanocarriers. 3) Design a novel and improved method to load EVs with therapeutic RNA. 4) Demonstrate the effect of EV-mediated delivery of therapeutic RNA in a murine model of myocardial infarction. The outcome of this research will fundamentally advance our understanding of the cellular processes enabling EV-mediated RNA transfer, which is of crucial importance for the development of EV-based and EV-inspired delivery systems. This research will accelerate clinical translation of an entire new class of therapeutics based on EVs and RNA.

Keywords: extracellular vesicles,exosomes,rna therapeutics