Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable Nitrite Biosensor for Food Safety monitoring (SOON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-04
End date: 2022-08-03
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

SOON is a career development scientific project aimed at offering an experience researcher (Dr. Oscar Andrés Loaiza) high quality research training in the field of Sustainable Biosensors for Food Safety monitoring, linking the knowledge of multidisciplinary fields of the bioelectroanalytical chemistry and advanced manufacturing technologies. Combining the researcher’s previous experience in analytical chemistry, nanomaterial fabrication and biosensors based on screen-printing technologies, and the hosting institution (BIOLAN Microbiosensores S.L.) proven expertise in developing electrochemical biosensors for food industry, in the framework of SOON we will research on the design and development of a future new generation of sustainable single-use biosensors for nitrite monitoring applied to food safety. Along with these scientific objectives, the project also focuses on developing the researcher’s transferable skills by strengthening communication, scientific writing, supervision and international mobility, preparing him to become an independent well-established scientist. SOON will link both basic research and industry thanks to the scientific excellence and industrial environment of the hosting organization (BIOLAN) and of the technological research centre during the secondment institution (NAITEC). In this sense, the researcher will be given a promising opportunity to transfer knowledge and results between academia and industry. After all, SOON aims at providing excellent working conditions to an ambitious international scientific talent in a high-level industrial and research environment, helping him to build his research career in Europe.

Keywords: food safety,food additives,nitrite,paper based biosensor,sustainable,eco friendly,portable,water based inks
Do Pathogen Extracellular Vesicles Deliver Crop Disease? (PathEVome)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2468260.0
EU funding (EUR): 2130541.0
Participants: 2
Project status: SIGNED

Filamentous plant pathogens (fungi and oomycetes) cause the most devastating crop diseases and thus significantly threaten global food security. Essential components of their virulence arsenal are proteins called cytoplasmic effectors that are delivered inside plant cells to suppress immunity. One of the major scientific challenges in this field is understanding how effectors are secreted and translocated into host cells; a question that is hotly debated. An exciting breakthrough in my laboratory revealed that cytoplasmic effectors accumulate in extracellular vesicles (EVs), implicating this as a delivery route. This critical discovery establishes a vital need to address: • What proteins reside in EVs and how do EVs traffic them between pathogen and host cells? • How are EVs formed and how are effectors packaged into them? • What are the routes for uptake of cytoplasmic effectors into host cells and how do they reach their destination? Each question will be answered by a corresponding workpackage (WP) that brings challenging, innovative approaches to the study of molecular plant pathology. In WP1 proteomics and transgenic approaches will allow the EV proteome to be determined and high-throughput automated electron microscopy will resolve the 3-dimensional organisation of the interface between plant and pathogen. In WP2, new molecular cell biological approaches and genome editing will facilitate an understanding of effector secretory routes and EV biogenesis. In WP3, fusion or endocytosis of EVs with plant cells will be studied and the endocytic routes to delivery of effectors to their final destination will be defined. PathEVome will develop a ground-breaking understanding of effector delivery from filamentous pathogens to the inside of living plant cells. It will provide tools and approaches beyond the current state-of-the-art in infection cell biology that can be broadly adopted to study the roles of vesicular transport in causing disease.

Keywords: cell biology,molecular transport systems,microbiology
The role of cell-to-cell variability in pneumococcal virulence and antibiotic resistance (PneumoCaTChER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 1999735.0
EU funding (EUR): 1999735.0
Participants: 1
Project status: SIGNED

Within clonal bacterial populations not all cells exhibit the same phenotype, even though they grow in the same environment. The molecular sources contributing to phenotypic variation are diverse and can originate from noise in gene expression to heterogeneity in growth rates or cell cycle state. Phenotypic variation helps pathogenic bacteria to elude the host immune response or resist antibiotic pressure. Vice versa, there is cell-to-cell variability in the host’s response towards pathogens that can be exploited by bacteria. How the combined cellular heterogeneity of both host and microbe contribute to infection outcome is poorly understood. The role of phenotypic variation on antibiotic resistance development is also unclear. Recently, we developed novel single cell imaging systems as well as genetic engineering and screening platforms for application to the important opportunistic human pathogen Streptococcus pneumoniae. In addition, we generated a dual-transcriptomics overview of pneumococcal infection of human lung epithelial cells and setup collaborations to perform several infection models. This now places us in an excellent position to investigate the mechanisms and the importance of single cell behaviour for pneumococcal virulence and antibiotic resistance. The driving hypothesis of this application is that the combined heterogeneity of host cells and pneumococci influences infection and antibiotic therapy outcome. To test this, we will use innovative approaches for infection biology by combining synthetic biology and quantitative single cell biology including single cell RNA-seq, CRISPRi, engineered bistable switches and microfluidics. We will reveal the molecular mechanisms underlying cell-to-cell variability and its importance in virulence and antibiotic resistance. Insights obtained in this project will lead to a better understanding of phenotypic variation and might result in new treatment strategies for pneumococcal infections.

Keywords: streptococcus pneumoniae,stochasticity,bistability,host microbe interaction,antibiotic resistance,heteroresistance,rna seq,single cell analysis,noise,microfluidics,crispri
Social Preferences, Well-Being and Policy (SOWELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1569820.0
EU funding (EUR): 1569820.0
Participants: 1
Project status: CLOSED

The goal of my project is to develop advanced research into the foundations of social preferences and well-being. If high value is placed on social cooperation and well-being for human development, then it becomes an urgent task to elaborate appropriate theories and measures, to understand their foundations, and to identify policies that will enhance them. I will advance this research in three steps: 1) The first stage will break new ground in the theory and measurement of social preferences and well-being, by exploiting the "Big Data" revolution and exporting behavioral economics into the field with online representative samples of societies and organizations. 2) The next stage will exploit those new large-scale behavioral measures to analyze the foundations of social preferences, sorting out the role of social cognition, individual life experience and social norms. 3) The third step will be to evaluate how policy affects social preferences and well-being, and in particular in the realms of education, employment and institutions. This project will yield proposals for a new agenda in the assessment of policies, by integrating criteria based on their impact on social cooperation and happiness. I will propose cutting-edge methods to carry out this research. First I will use the revolutionary possibilities of Big Data to test theories of happiness by exploiting high-frequency behavioral measurements of well-being from Web 2.0. Second I will use computational sciences to develop an online laboratory aimed at studying social behaviors on representative samples of the population and how they relate with real world production and policy, thus addressing the lack of external validity that currently hampers experimental economics. Last, I will combine these new measurements of behavior with randomized trials, in order to assess policy within a new paradigm based on social preferences and well-being. My research is both theoretical, empirical and trans-disciplinary.

Keywords: social preferences,well being,behavioral economics,psychology,big data,organizations,policy
Cryptography for Privacy and Integrity of Computation on Untrusted Machines (PICOCRYPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999873.0
EU funding (EUR): 1999873.0
Participants: 1
Project status: SIGNED

Due to phenomena like the ubiquity of the Internet and cloud computing it is increasingly common to store and process data on third-party machines. In spite of its attractive aspects, this trend raises a number of security concerns, including: How to ensure that the results computed by third parties are correct (integrity) and no unauthorized information is leaked (privacy)? The current way to deal with these problems is to trust third parties under legislation guarantees. This approach assumes that third-party machines stay honest all time, even if they get hacked! This is unrealistic and contradicted by the numerous security incidents that are regularly reported. In contrast, our vision is that any computing device must be able to store and process data on untrusted machines without risking for privacy and integrity and without the need of trusting these machines. Recent trends in cryptography promise solutions to realize our vision but the existing generation of protocols is limited due to its high costs and its poor support of emerging applications such as data streams processing. The grand challenge of this project is to invent a new generation of cryptographic protocols for computing securely on untrusted machines in a way that is cost-effective and suitable for future application scenarios. Towards this goal we will design new methods to scale up the applicability of cryptographic protocols. One of our key approaches will be trading generality for efficiency. While existing solutions are either general but impractical or efficient but of limited applicability, in PICOCRYPT we will look for protocols that support a wide range of applications while staying efficient. The PICOCRYPT solutions will enable a paradigm shift in the way privacy and integrity will be enforced and will have impact in the IT world by making remote computing safer not only for citizens but also for public and private organizations that due to the current risks renounce to these services.

Keywords: cryptography,privacy,integrity,cloud computing,data protection
Dynamics of Supersymmetry in Curved Space (CurvedSusy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Sweden,Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1145879.0
EU funding (EUR): 1122866.25
Participants: 2
Project status: CLOSED

Quantum field theory provides a theoretical framework to explain quantitatively natural phenomena as diverse as the fluctuations in the cosmic microwave background, superconductivity, and elementary particle interactions in colliders. Even if we use quantum field theories in different settings, their structure and dynamics are still largely mysterious. Weakly coupled systems can be studied perturbatively, however many natural phenomena are characterized by strong self-interactions (e.g. high T superconductors, nuclear forces) and their analysis requires going beyond perturbation theory. Supersymmetric field theories are very interesting in this respect because they can be studied exactly even at strong coupling and their dynamics displays phenomena like confinement or the breaking of chiral symmetries that occur in nature and are very difficult to study analytically. Recently it was realized that many interesting insights on the dynamics of supersymmetric field theories can be obtained by placing these theories in curved space preserving supersymmetry. These advances have opened new research avenues but also left many important questions unanswered. The aim of our research programme will be to clarify the dynamics of supersymmetric field theories in curved space and use this knowledge to establish new exact results for strongly coupled supersymmetric gauge theories. The novelty of our approach resides in the systematic use of the interplay between the physical properties of a supersymmetric theory and the geometrical properties of the space-time it lives in. The analytical results we will obtain, while derived for very symmetric theories, can be used as a guide in understanding the dynamics of many physical systems. Besides providing new tools to address the dynamics of quantum field theory at strong coupling this line of investigation could lead to new connections between Physics and Mathematics.

Keywords: quantum field theory,supersymmetry
Innovative training in methods for future data (IMforFUTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Croatia,Croatia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-04-01
End date: 2021-07-31
Duration (months): 52.0
Total project cost (EUR): 2864761.2
EU funding (EUR): 2864761.2
Participants: 9
Project status: CLOSED

IMforFUTURE is an innovative multidisciplinary and intersectoral research training programme which addresses current shortcomings in omics research. We aim to open the new research horizon in integration of genetics, glycomics, and epigenomics datasets into systems biology by developing innovative methods for high throughput omics and for integrative analysis of omics data. We focus on ageing, which is the biggest single risk factor for many diseases. By application of our novel methods to emerging datasets representing inflammation and immunology, IMforFUTURE will contribute to understanding of the underlying biological processes involved in diseases and ageing. To be successful in future multidisciplinary environments in Academia or Industry, ESRs need to be able to act as bridge between several diverse disciplines. Our ESRs need to overview all steps from data production via data analysis to data interpretation. In our consortium 7 academic and 4 industrial partners - experimental and theoretical - participate in research and training via teaching, offering secondments and hosting ESRs. We offer courses in high throughput methodology, genomics and statistics. Secondments will be to partners with complementary disciplines and intersectoral. Emphasis will be data management, data stewardship, entrepreneurship, and complementary skills. Interdisciplinary collaborations among ESRs will be stimulated by working on the same studies, in which new data will be generated, integrated with other datasets, analyzed with novel methods and interpreted. At the end of the project the ESRs will present and discuss their research in an integrated workshop. Our ESRs will be ready and equipped for new-generation multidisciplinary researchers. They will significantly contribute to omics research in relationship to human disease and health and knowledge translation. A conference to disseminate our work to researchers in Academia and Industry, and to stakeholders will be organized.

Keywords: integrated analysis,network,mass spectrometry,high througput,epigenetics,metagenomics,bioinformatics
Non-trAditioNal sTable mEtaL isotOPE (Fe, Mg, Zn) fractionation: a case study from the Bushveld Complex, South Africa (ANTELOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-23
End date: 2020-06-16
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Mafic layered intrusions, formed by the slow cooling and differentiation of basaltic magmas within the crust often contain enormous metallic ore resources, of vital importance for industrial and societal applications. The ca. 2.0 Ga Bushveld Complex in South Africa is by far the largest mafic layered intrusion on Earth, and contains > 80% of the world’s Platinum-Group Elements (PGE) and huge quantities of Cr, hosted within a few nearly monomineralic dense oxide layers which are continuous over 100’s of kilometers. Despite many decades of scientific research, the processes that resulted in the formation of these magnificent layering features and the accumulation of precious metals to such high concentrations are heavily debated. Part of the problem arises from the fact that compositional data suggests the influence of post-magmatic processes and fluid circulation operating in the magma chamber. Such processes are likely to have modified the primary cumulate pile and influenced precious metal distribution, but the extent to which these rocks have been subjected to subsolidus modification is not known. I propose to develop new geochemical tools to quantify the influence of these processes, using an unprecedented precise approach of Fe, Mg and Zn isotope measurements on ferromagnesian sililcates, oxides and sulfides. Not only will the results support further precious metal exploitation by expanding our understanding of the formation and evolution of mineralized oxide layers in the Bushveld, but they will also be of high scientific relevance for all applications of high-temperature stable isotope geochemistry across the fields of igneous and metamorphic petrology as well as geo- and cosmochemistry.
FIOLENCE: A New Research Space at the Food/Violence Nexus (FIOLENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-15
End date: 2023-09-14
Duration (months): 36.0
Total project cost (EUR): 241398.72
EU funding (EUR): 241398.72
Participants: 1
Project status: CLOSED

Food and violence are two major themes in 2019, together figuring in five of the EU’s six research priorities. Given two themes of such contemporaneity, purchase, and formalized priority, the following gap is surprising: There is almost no work that attempts to understand the relationship between food and violence. The goal of this project is to breach that gap, lay the first bricks in the foundation of a new research line at the food/violence nexus, and set the trajectory for what I expect to become a thriving area of work at the scholarship/society interface over the next decade. This project disrupts the facile approaches to both food and violence that predominate in mainstream attention and policy action. It will open a new research space at the food/violence nexus; amplify the reach and impact of food studies as a field; create operationalizable methodological and theoretical models at the underexploited anthropology/philosophy interface; forge continuable bonds among researchers, universities, civil society organizations, and UN bodies across Europe and the Americas; and introduce cutting-edge critical research into active human rights deliberations. It will also restart the career and renew the capacity for intellectual and policy contribution of a tenacious ER disabled and disembedded by a catastrophic medical error. The ER will be supervised by Dr. F.X.Medina in UOC’s world-renowned FoodLab research group, carry out a secondment with Dr. E. Pérez in CSIC’s pioneering Science, Technology, and Gender (STG) research group, and perform three study visits to the UN Office of the High Commission for Human Rights (OHCHR).

Keywords: autoethnography,critical discourse analysis,food studies,philosophy of praxis,critical ethical philosophy,feminist philosophy,science and technology studies sts,force feeding