Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Valuing Public Goods in a Populist World: A Comparative Analysis of Network Dynamics and Societal Outcomes (VALPOP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Denmark,Poland,Türkiye,Italy,New Zealand
Call: What is the long-term impact of rule of law and other European values on socio-economic outcomes? (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 2994425.0
EU funding (EUR): 2994425.0
Participants: 9
Project status: SIGNED

The EU strives to create socio-economic wealth for its citizens by ensuring fair and equal access to public goods. These goods are nonexcludable and non-rivalrous utilities that benefit society. Countries are the primary providers of these goods, but private firms, NGOs, politicians, and the media also play a role. A central challenge is to govern the creation and fair distribution of public goods as actors interact and collaborate in their creation. Institutions ensure fair and equal access to public goods, as purely market-based supply would result in misallocations. The rule of law corrects such misallocation by stipulating subsidies, taxes, regulations, or monopolies for certain public goods. However, populism has gained momentum globally, challenging democracy and the rule of law. It involves gaining and maintaining power by targeting formal and informal institutions, including the rule of law. Populist politics typically create an in-group and an out-group, interfering in creating and distributing public goods. This creates countervailing pressures between the rule of law and populism, affecting the distribution of public goods. We study how the rule of law and populism impact the creation and distribution of public goods by societal actors. Our analysis takes a network perspective and considers actors' interactions, collaborations, and potential collusions for a multi-dimensional view of socio-economic outcomes. We investigate how the structure of these networks and their degree of populism, a construct we define as “networked populism,” affect the contribution of societal actors to socio-economic outcomes. In summary, our study analyses how the rule of law and populism impact the creation and distribution of public goods by societal actors.

Keywords: public goods,rule of law,populism,network perspective,socio economic outcomes
Sub-Neptunes as Predecessors for Earth-like planets Atmospheres Research for Habitability with the ELTs (SPEAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2453750.0
EU funding (EUR): 2453750.0
Participants: 1
Project status: SIGNED

One of the most significant discoveries of the past decades is the realization that there are more planets than stars in our Galaxy, with a planet diversity that has far surpassed our expectations. A major focus of 21st-century astronomy is the characterization of Earth-sized planets in the habitable zones (HZPs) around nearby M dwarfs and the search for possible biomarkers in their atmospheres. This is driving the development of advanced, dedicated space missions and ground-based Extremely Large Telescopes (ELTs). These upcoming ELTs, equipped with instruments like the ANDES high-resolution spectrograph, aim to probe the atmospheres of HZPs in detail, moving beyond basic parameters to explore their atmospheric composition. Current techniques, like transmission spectroscopy, have been successful in characterizing larger planets but will face significant challenges when applied to small, rocky HZPs. Correcting for stellar, planetary, and systematic signals which are undetectable with current instruments will become crucial, as their signatures will be of the same size or larger than the planetary signals we will be looking for. Moreover, the habitability of these planets is under debate due to their susceptibility to atmospheric loss from intense stellar radiation. To address these challenges, the SPEAR project proposes a multi-faceted approach to develop new simulations and data analysis methodologies that can solve or mitigate the key observational limitations of the ELTs. The project will also develop advanced simulation tools, conduct empirical studies on sub-Neptune planets as benchmarks targets for habitability studies, design optimal observational strategies for the ELTs, and create a prioritized list of targets that expand the parameter space to search for habitability and biomarkers. By the time the ELTs become operational, SPEAR will provide the missing essential tools needed to fully exploit these powerful observatories in the search for habitable world

Keywords: exoplanet transits,extremely large telescopes,habitability,life,atmospheres,simulations
Collaborative development and dissemination of workflows and techniques for using Correlative Light, Electron and X-ray Microscopy to progress research into the understanding and treatment of diseases (CLEXM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,France,Spain,Ireland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2724529.37
EU funding (EUR): 2480594.4
Participants: 12
Project status: SIGNED

Correlative multimode imaging is the only way to reveal a composite view of a biological sample with the multidimensional information about its macro-, meso- and microscopic structure, dynamics, function and chemical composition that is required in order to understand biomedical processes and diseases. Project CLEXM addresses an urgent need to demonstrate, promote and disseminate the benefits of this technique in the fields of disease and drug therapy research and especially to early-career researchers. The premise of project CLEXM is that there is a growing need for disease and drug therapy researchers to understand the linkages between structural and functional changes that occur in a cell and to be able to observe these from the cellular (micrometre) to the molecular (nanometre) scale. Correlative Light and Electron Microscopy (CLEM) is the current state-of-the-art for achieving this, but the technique is extremely complex and slow. CLEXM postulates that the integration of a third imaging modality, Soft X-ray Tomography (SXT), into CLEM will make it easier and faster for researchers to correlate cellular structure with cellular function. Correlative Light, Electron and X-ray Microscopy (CLEXM) can be combined in a number of ways and the benefits will be demonstrated in a number of different use cases. This would be too difficult and too much to achieve as a single research project or as a single MSCA Postdoctoral Fellowship, however, it lends itself to be most easily achieved as a network of complementary individual projects, under an MSCA Doctoral Network action. The overarching objective of project CLEXM is to provide high-level training in the field of correlative multimode imaging to a new generation of doctoral candidates to provide them with the transferrable skills necessary for thriving careers in a high-growth area that will aid researchers in their quest to understand disease and to develop effective therapies.

Keywords: correlative multimode imaging,cell structural imaging,disease research,therapeutics research,soft x ray tomography,nano tomography,fluorescence,transmission scanning electron microscopy,fibsem
Confidential Computing and Privacy-preserving Technologies for 6G (CONFIDENTIAL6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,France,Netherlands,Serbia,Finland,Spain,Austria,Ireland
Call: Secure Service development and Smart Security (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 5263864.5
EU funding (EUR): 4999153.0
Participants: 18
Project status: SIGNED

6G infrastructures must ensure reliability, trust and resilience on a globally connected continuum of heterogeneous environments supported by the convergence of networks and IT systems to enable new future digital services. The substantial increase of coverage and network heterogeneity, raises severe concerns that 6G security and privacy can be worse than the previous generations. The 6G network should be a deep integration of emerging AI tools, new hardware components and accelerators, compute and networking functions, IoT and edge nodes. Contemporary security is not designed for serving a massive number of connected and high-mobility heterogeneous devices. CONFIDENTIAL6G emphasizes on privacy preservation and security of sensitive data by focusing on protection of data: • In use. This is an unsolved issue with solutions just emerging with Confidential Computing. • In transit. CONFIDENTIAL6G will enhance communication protection with post-quantum cryptography, blockchain technologies and secure data access control and traceability platforms. • At the Edge. CONFIDENTIAL6G will work on specifying the post-quantum cryptographic approach most appropriate to cater for constrained Edge and IoT devices. Additionally, in order to avoid data movement from the Edge and increase trust and security, Federated AI/ML will be researched. CONFIDENTIAL6G will base its research on 3 pillars: Post-quantum cryptography, Confidential Computing and Confidential Communication. CONFIDENTIAL6G will test and validate the developed solutions in three use cases: 1) Predictive maintenance for airline consortium using blockchain-based data sharing platform and federated AI/ML orchestration, 2) Privacy-preserving confidential computing platform that enables mitigation of internal threats for telecom cloud providers and 3) Intelligent connected vehicle, mission-critical services, OTA updates, FL/ML and vehicle to infrastructure communication.

Keywords: 6g,confidential computing,homomorphic encryption,cryptography,collaborative and federated ai ml,blockchain,smart contracts,confidential orchestration
ASYNO2: Providing unprecedented concepts for the access of enantiopure Nitrogen-containing molecules (ASYNO2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 332506.56
EU funding (EUR): 332506.56
Participants: 2
Project status: CLOSED

Organic synthesis, the culminating point of many areas, is greatly beneficial to European development of emerging technologies and asymmetric catalysis is amongst the most challenging but very powerful method to access enantiopure molecules. Provide new methods to access enantiopure compounds is of high interest when it comes, for instance, to drug delivery. More than 40% of the new drugs approved by the FDA in 2015 bear chiral amine (20% in 2005). This increasing need to access chiral amines and its precursors resonates as a call to chemists to pave new routes for the elaboration of these derivatives. Despite the versatile nature of the nitro group, readily converted into amines or many other pharmaceutically relevant functionalities, no direct asymmetric nitrative process has been reported to date. Herein, ASYNO2 aims to merge photoredox or electrochemical with asymmetric organo- or acid-catalysis for the development of the first asymmetric nitration reactions. Despite this synthetic challenge, novel and very promising routes, along with the support of computational studies are considered and discussed in details in this research plan. Preliminary results provided proof of concept at the synopsis of this collaborative work between the Laboratory of Catalysis and Organic Synthesis of the University of Fribourg (UniFr, photo- and electrochemistry, asymmetric synthesis expertise, Outgoing phase) and the Institute of Chemistry of Poitiers (IC2MP – UMR CNRS 7285 – France, Superacid and NMR expertise, return phase). Superacid chemistry is only mastered by very few research groups in the world and is a European specificity of the group at Poitiers and will be applied for the first time to asymmetric catalysis. Furthermore, this program will provide a prolific fellow with an internationally competitive training, with the aim of advancing the career of an autonomous scientist in the EU and the next generation of multidisciplinary researchers in pharmaceutical sciences.

Keywords: asymmetric,nitration,photochemistry,electrochemistry,superacid
Breaking down aging phenomena in Resistive Plate Chambers operated with eco-friendly gas mixtures (EcoRPCchem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Switzerland,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-20
End date: 2028-06-19
Duration (months): 36.0
Total project cost (EUR): 388940.52
EU funding (EUR): 388940.52
Participants: 4
Project status: SIGNED

With the enforcement of EU regulations 2024/573, the production and usage of Tetrafluoroethane (R134a) has been strongly regulated. This gas is a key component in the gas mixture of Resistive Plate Chambers, a detector technology widely employed in high-energy physics. A potential, more environment-friendly, substitute for this gas is Tetrafluoropropene (HFO) and several promising HFO-based mixtures have been proposed. The long-term behavior (aging) of RPCs operated with these mixtures is typically studied by exposing several detectors flushed with an HFO-based gas mixture to a radioactive source and by studying the stability of the absorbed current and RPC performance over time Experimental tests are crucial to spot and quantify aging effects, but can rarely provide an explanation for their origin. This requires a deeper understanding of the microscopical modifications of the materials induced by the HFO decomposition when exposed to irradiation. This project aims at breaking down the aging phenomena of several RPC components in their basic building blocks by comparing the chemical (EDX spectroscopy and SEM analyses) and electrical (resistivity) features of new and aged samples of RPC materials. The results of these analyses will be used to formulate a model to describe the observed effects and develop a simulation code, allowing for a systematic test of the aging properties of different HFO-based gas mixtures. I will carry out my research at the High Voltage Laboratory of the ETH Zurich University and at the Physics Department at the University of Torino, with the guidance of Prof. Christian Franck and Martino Gagliardi, leading experts on eco-friendly high-voltage gaseous insulation and RPC detectors respectively, while the chemical analyses will be performed at the CERN chemical laboratory. On a personal level, this project will strengthen my academic profile significantly and provide an ideal training ground for my project- and time-management skills.

Keywords: resistive plate chambers,eco friendly gas mixtures,edx spectroscopy,aging studies,material compatibility
Empowering Community-Led Action in the Atlantic & Arctic (BlueActionAA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Research and Innovation actions
Countries involved: Ireland,Portugal,France,Norway,Spain,Denmark
Call: Community-led actions to restore our ocean, seas and waters (HORIZON-MISS-2024-OCEAN-02, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 12499786.25
EU funding (EUR): 12499786.25
Participants: 8
Project status: SIGNED

Empowering Community Led Action in the Atlantic & Arctic (ACT-AA) aims to mobilise and engage communities across the Atlantic and Arctic regions in ambitious efforts to restore and protect marine and freshwater ecosystems. By fostering community-led initiatives, the project seeks to make significant progress toward the objectives of the EU Mission “Restore our Ocean and Waters by 2030.” ACT-AA will provide comprehensive support to local stakeholders, including financial aid through cascading grants, technical assistance, and capacity-building resources to ensure effective and sustainable ecosystem restoration actions. ACT-AA’s key components include: 1. Cascading Grants for Community-Led Pilot Actions: Awarding at least 5 grants ranging from EUR 200,000 to EUR 2 million each to innovative projects addressing local ecological and socio-economic challenges. 2. Support for Transition Agendas: Funding at least 20 strategic roadmaps, each up to EUR 100,000, to guide communities in achieving the Mission’s objectives and ensuring long-term sustainability. 3. Technical Assistance: Providing tailored support, including business plan development, impact assessments, and capacity-building programs, to enhance local stakeholders’ ability to implement and scale innovative solutions. Expected outcomes include: 1. Demonstrable, measurable progress towards the Mission’s objectives through well-managed, community-led actions. 2. Support for EU member states and stakeholders in implementing marine and freshwater ecosystem related legislation. 3. Increased engagement and resource mobilization from communities to restore oceans, seas, and waters. 4. Enhanced readiness at the local level to deploy innovative restoration solutions. ACT-AA will ensure broad participation, leveraging local knowledge and fostering long-term commitment to ecosystem protection, thus contributing significantly to the European Green Deal’s biodiversity, pollution, and climate targets.

Keywords: community led pilot actions,transition agenda,mission ocean and waters,atlantic and arctic,provision of technical assistance,cascade call grant management
Development of a universal fluorescence sybody-based biosensor for the in-vivo study of protein dynamics (UniverSy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

The development of genetically-encoded fluorescence sensors revolutionized the monitoring of biochemical processes in living cell by reporting a change in their fluorescence properties in response to a specific aspect of their environment. However, the design of such biosensors is not trivial and available tools only target a limited set of phenomena. Current limitations prevent the monitoring of crucial processes such as the activity of membrane associated receptors which are a rich target for drug development. Simple binders are much easier to develop than biosensors, for instance nanobodies can bind a plethora of targets with high affinity and specificity, sometimes for a particular conformation. The host research group recently developed a molecular design to convert nanobodies into fluorescent biosensors. To elicite a fluorescent signal in presence of the target, this NanoBlock sensors require the development of an intracellular blocking peptide that will be displaced upon binding to the target. This limiting step prevent the application of the NanoBlock design to a large number of targets. This objective of this proposal is to develop an entirely new class of fluorescent biosensors by engineering the NanoBlock technology so that nanobodies can be converted into fluorescent biosensors without the need for a distinct blocking peptide creating a ‘plug and play’ system. This UniverSy technology will open the possibilities to visualize many more cellular processes to gain fundamental insight on protein activity and the development of therapeutics targeting these processes. The development of the UniverSy sensor will consist in the generation of dual affinity nanobodies binding their original target and a specific peptide sequence; the demonstration of the versatility of the UniverSy framework to target various proteins in vitro and in living cell and the use of UniverSy in a fluorescence assay to quantify the activation of GPCR for drug screening applications.

Keywords: protein dynamics,genetically encoded fluorescence protein,nanobody,membrane receptor