Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Whole-of-Society Conflict Prevention and Peacebuilding (WOSCAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Ukraine,Spain,Germany,Georgia,France,Netherlands,Netherlands,Yemen,United Kingdom,Mali
Call: Conflict prevention and peace building topic 1: Enhancing the civilian conflict prevention and peace building capabilities of the EU (H2020-BES-2014, 2014)
Start date: 2015-06-01
End date: 2017-11-30
Duration (months): 30.0
Total project cost (EUR): 2018034.75
EU funding (EUR): 1990114.25
Participants: 10
Project status: CLOSED

This proposal seeks to enhance the capabilities of the EU for implementing conflict prevention and peacebuilding interventions through sustainable, comprehensive and innovative civilian means. It intends to address some of the dilemmas and paradoxes of external interventions that aim for local ownership in third countries, by exploring principles, processes and tools that can enhance EU capabilities. This will be achieved through the project’s Review, Reflect, Recommend and Innovate objectives. ‘Review’ will assess past and ongoing conflict prevention and peacebuilding initiatives of the EU and its partners, focusing on three types of EU interventions: multi-track diplomacy, security sector reform, and governance reform. The assessment will be based on field research in Georgia, Mali, Ukraine and Yemen, and desk reviews looking beyond these countries. ‘Reflect’ will create a ‘community of practice’ providing forums for dialogue that will bring together policymakers, civilian and military practitioners, academic experts and beneficiaries of EU interventions. These will validate and apply the evidence base by focusing on cross-cutting themes: local ownership, gender, multi-stakeholder coherence, civil-military synergies and ICTs. ‘Recommend’ will elaborate the project findings into a tailored set of recommendations and enhance their impact through direct policy engagement and an international dissemination strategy. ‘Innovate’ will contribute significantly to civilian conflict prevention and peacebuilding by identifying research priorities and tools, and enhancing the potential of ICTs. The project Whole-of-Society Approach to Conflict Prevention and Peacebuilding is a conscious attempt to address the relationships of peacebuilding actors within a wider cultural and institutional context. It deals with issues of coordination, synergies and inclusivity of peacebuilding efforts, where diverse stakeholders have a role to play in the process.

Keywords: conflict prevention,peace building,inclusivity,local ownership,civil military,security sector reform,governance,mediation and dialogue
New circular polarized light-emitting electrochemical cells. (NEWCPLECS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Light emitting electrochemical cells (LECs) are key devices in the future development of lighting technologies as they are much more competitive than OLEDs from an economic/manufacturing point of view. In addition, the compatibility of LECs with metal free electrodes allow the design of flexible/printable/customizable devices. Despite their potential to overcome the OLEDs, this technology has been limited by the sparse number of emissive complexes that have produced good performing LECs and the prize of them. Besides, these good performing LECs are limited to the yellow/green spectral region. The use of Cu-iTMC in LECs technology is a promising approach to access to cheap and easy to manufacture LECs that cover the whole Visible-NearIR region. However, Cu-iTMC show an inherent lack of stability that inhibits their implementation. We propose the synthesis of mesogenic Cu-iTMC to enhance their stability. Besides, this will be the first incursion of Cu-iTMC in the design of flexible/printable LECs. From the other side, while circular polarized (CP) devices are crucial in display technology and there are a good number of CP-OLEDs, there are no precedents of CP-LECs. In this proposal, we also establish a simple and approachable strategy to design the very first family of intrinsically polarized LECs. In summary, we present synthetic routes and chemical tools to prepare functionalized Cu-iTMC that will be used in the manufacture of a whole new generation of LECs with a) High stabilities b) Polarized emission b) Flexible mechanical properties.

Keywords: light emitting electrochemical cells,circular polarized emission,quasi solid state devices
Silicon Alloying Anodes for High Energy Density Batteries comprising Lithium Rich Cathodes and Safe Ionic Liquid based Electrolytes for Enhanced High VoltagE Performance. (Si-DRIVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Germany,Germany,Spain,Italy,Ireland,Switzerland,Belgium,France,Netherlands
Call: Materials for future highly performant electrified vehicle batteries (RIA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-07-31
Duration (months): 55.0
Total project cost (EUR): 7999492.5
EU funding (EUR): 7999492.5
Participants: 18
Project status: SIGNED

Si-DRIVE will develop the next generation of rechargeable Li-ion batteries, allowing for cost competitive mass market EVs by transformative materials and cell chemistry innovations, delivering enhanced safety with superior energy density, cycle life and fast charging capability using sustainable and recyclable components.The technology encompasses amorphous Si coated onto a conductive copper silicide network as the anode with polymer/ionic liquid electrolytes and Li-rich high voltage (Co-free) cathodes via processes that are scalable and demonstrably manufacturable within Europe.The components have been demonstrated at TRL3 through preliminary lab-scale analysis, with a clear component improvement strategy to arrive at a TRL5 prototype demonstration by the end of Si-DRIVE. Comprehensive theoretical and experimental studies will probe and control interfacial processes that have heretofore limited Li-ion technologies to incremental gains, guiding materials design and eliminating capacity fade mechanisms.The Si-DRIVE technology will exceed the stringent demands of EV batteries where safety is paramount, by dramatically improving each component within the accepted Li-ion platform and achieving this in a market competitive process with whole of life considerations. The technology will also demonstrate suitability for 2nd life applications at reduced energy density beyond the primary EV lifetime, prior to cost effective materials recycling, consistent with a circular economy.The Si-DRIVE consortium boasts the required academic and industrial partner expertise to deliver this technology and spans material design and synthesis, electrochemical testing, prototype formation and production method validation, life cycle assessment and recycling process development.

Keywords: silicon,ionic liquids,lithium rich cathodes
Controllability of biological networks (NETCONTROLOGY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-06
End date: 2023-01-05
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: CLOSED

A dynamic system is controllable if, given suitable inputs, it can be driven from any initial state to any desired final state in finite time. Despite the advances in network science, computational approaches that can be used to characterize the dynamics of complex, biological systems are still lacking. This project aims at determining how biological networks can be controlled with focus on two cutting-edge case studies from medicine. Existing controllability approaches work essentially on graphs and do not consider other constraints typically arising in biological systems (e.g. steady-state). This strengthens the need for development of such methods. In this project, nonlinear, quantitative and dynamic network models will be developed for biological networks with multiple regulatory mechanisms. In these networks, it is vital to identify the subset of key components and regulatory interactions whose perturbation leads to the desirable functional changes. However, it is typically neither feasible, nor necessary to control the whole network. Instead, for many practical applications, it would suffice to control a preselected subsystem of target nodes. Besides full controllability, target controllability of the networks will also be addressed. Different measures will be developed to compare networks based on their controllability. The established network control principles will be exploited to (a) reprogram cancer networks through their druggable vulnerabilities to improve anticancer therapeutics (case study 1), and (b) target the enzymatic sources of relevant oxidative stress to support neuroprotection in stroke (case study 2).

Keywords: full and target controllability,biological networks,computational models,cancer,multi target drugs,stroke,reactive oxygen species
Social Chemosignaling as a Factor in Human Behavior in both Health and Disease (SocioSmell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-01-31
Duration (months): 65.0
Total project cost (EUR): 2074206.0
EU funding (EUR): 2074206.0
Participants: 1
Project status: CLOSED

We test the working hypothesis that humans are constantly engaging in social chemosignaling, and that this serves as a major yet underappreciated force in shaping human social behavior. A major component of social chemosignaling in macrosmatic mammals is conveying of social status, namely dominance/submissiveness. We start by testing the novel hypothesis that humans similarly share information on social status through chemosignals. In support of this, we provide pilot data for a "smell of dominance". Next, we ask how do humans sample these social chemosignals? We hypothesize that handshaking serves subliminal sampling of social chemosignaling, and provide comprehensive pilot data implying that humans indeed subliminally sniff their own hands after shaking. Given the importance we attribute to social chemosignaling, one may ask why aren't anosmic individuals significantly socially impaired? We test the hypothesis that social chemosignals are processed by brain mechanisms independent of the main olfactory system. In support of this, we provide pilot data implying a brain response to social chemosignals in individuals with congenital anosmia. Finally, we ask what happens if social chemosignaling is selectively impaired? Given the social impairment we would predict following such social anosmia, we hypothesize that it may be a component of autism spectrum disorder. In support of this hypothesis we provide pilot data of altered social chemosignaling in high functioning adults with autism, and altered olfactory responses in children just diagnosed with autism. The latter implies a potential non-verbal non-task dependent diagnostic measure for autism. Together, this combines to a radically different perspective on human social behavior. We argue that humans are constantly chemosignaling, and that uncovering these effects will provide for better understanding of human social behavior, and potential diagnosis and treatments for diseases involving altered social performance.

Keywords: social chemosignaling
Tissue Cytokines at the Nexus of Immune Cell-Cardiac Stromal Cell Interaction (CardiacStroma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2424000.0
EU funding (EUR): 2424000.0
Participants: 1
Project status: SIGNED

Myocarditis is an acute inflammatory heart disease that can progress to chronic cardiomyopathy and heart failure. Since there is no specific treatment recommendation available for myocarditis and subsequent inflammatory cardiomyopathy, there is an urgent need to dissect the pathological principles underlying cardiac inflammation and to target those molecular pathways that are at the core of the pathological process. My recent research places cross-reactive CD4+ T cells at the center of inflammatory cardiomyopathy pathogenesis. The activation and sustenance of cardiotropic T cells is controlled in immune cell-nurturing niches that are generated by fibroblastic stromal cells through the provision of tissue cytokines of the TGF-beta superfamily. The overarching goal of this project is therefore to decipher the molecular pathways that govern the interaction of immune cells with stromal cells in the cardiac tissue through the combination of state-of-the-art pre-clinical models, novel methods from quantitative systems biology, functional validation by antibody blockade, and assessment of the translational relevance through the analysis of cardiac biopsies from human patients. The generation of antibodies that neutralize a distinct set of tissue cytokines or their inhibitors will not only serve as functional validation, but will open possibilities for future translational development. Moreover, the utilization of spatial transcriptomics for the analysis of human heart samples will open new avenues for innovative research both in immunology and in cardiology. Overall, I expect that the planned research program will deliver (i) novel targets for the treatment of myocarditis and inflammatory cardiomyopathy, (ii) validated prototype antibodies that ameliorate cardiac inflammation through the manipulation of stromal cell-immune cell interaction, and (iii) a comprehensive analysis of the changes in the cellular and molecular landscape during cardiac inflammation in humans.

Keywords: fibroblastic stromal cells,myocarditis,inflammatory cardiomyopathy,cd4 t cells
Creating a Panoramic View of Emotion Communication (PAVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 269998.08
EU funding (EUR): 269998.08
Participants: 2
Project status: SIGNED

People communicate emotions constantly. They express their emotions, intentionally and unintentionally, through their behaviour, language, and body; perceivers readily observe and interpret those expressions in others. These emotion communication dynamics are key to successful social interaction. The proposed project will capture these dynamics by adopting a panoramic, multi-modal approach to emotional communication: looking at how the same emotional experience is expressed in multiple streams (e.g., face-to-face and on social media), and is perceived by multiple observers (e.g., friends, romantic partners, and automated algorithms). This approach can go beyond existing research on emotion communication, which is stymied by attempts to isolate specific unimodal communication streams. The outgoing phase, which will take place at Princeton University, supervised by Prof. Diana Tamir, will use this integrated approach to examine whether the positive outcomes generally associated with emotional disclosure requires the disclosee to gain accurate understanding of the discloser’s emotions; to identify when different perceivers will be accurate vs. inaccurate; and to develop new algorithms for automated multi-modal emotion perception. The incoming phase, which will take place at the University of Haifa, supervised by Prof. Simone Shamay-Tsoory, will examine the neural mechanisms supporting the emotion communication processes studied in the outgoing phase. The project has the capacity to advance basic science in psychology, neuroscience and computer science, with multiple real world applications: distinguishing the roles of disclosure and accuracy, can help encourage healthy, beneficial disclosure; identifying relative strengths and weaknesses of communication modalities can help improve interpersonal accuracy, which can lead to better relationships; improved automated emotion assessment can help emotion research, clinical treatment, and emotion-aware software development.
energy services demonstrations of demand response, FLEXibility and energy effICIENCY based on metering data (FLEXICIENCY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Italy,Italy,Spain,Spain,Belgium,Slovenia,Sweden,Finland,Finland,France,United Kingdom
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 19010417.26
EU funding (EUR): 13946741.0
Participants: 30
Project status: CLOSED

Four major Distribution System Operators (in Italy, France, Spain and Sweden) with smart metering infrastructure in place, associated with electricity retailers, aggregators, software providers, research organizations and one large consumer, propose five large-scale demonstrations to show that the deployment of novel services in the electricity retail markets (ranging from advanced monitoring to local energy control, and flexibility services) can be accelerated thanks to an open European Market Place for standardized interactions among all the electricity stakeholders, opening up the energy market also to new players at EU level. The proposed virtual environment will empower real customers with higher quality and quantity of information on their energy consumptions (and generation in case of prosumers), addressing more efficient energy behaviours and usage as through advanced energy monitoring and control services. Accessibility of metering data, close to real time, made available by DSOs in a standardized and non-discriminatory way to all the players of electricity retail markets (e.g. electricity retailers, aggregators, ESCOs and end consumers), will facilitate the emergence of new markets for energy services, enhancing competitiveness and encouraging the entry of new players, benefitting the customers. Economic models of these new services will be proposed and assessed. Based on the five demonstrations, while connecting with parallel projects funded at EU or national levels on novel services provision, the dissemination activities will support the preparation of the Market Place exploitation strategies, as well as the promotion of the use cases tested during the demonstration activities.

Keywords: distribution network,electricity retail market,demand response,energy efficiency,metering data,flexibility
Noncoding RNA MEG3 inhibitor for Heart Failure Treatment (MEGFIB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-07-01
End date: 2021-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cardiac fibrosis is a hallmark of and mechanistically involved in heart failure; a disease will high clinical unmet need and fundamental socioeconomic importance. Specific treatments of cardiac fibrosis are lacking. RNAs that do not code for proteins comprise a large portion of the human genome. These so-called noncoding RNAs are emerging as important players in disease pathogenesis, yet their functional roles are ill understood. Our group currently pioneered first clinical testings on noncoding RNA inhibitors in heart failure patients showing the enormous clinical translational potential of such next-generation therapeutics. We now aim to develop a new approach to treat selected heart failure patients, which show increased signs of cardiac fibrosis. Within the ERC grant LONGHEART we have identified a lncRNA meg3 to be a novel and innovative target in heart failure pathologies with fibrosis (Circ Res. 2017 Aug 18;121(5):575-583; Fig. 1). Importantly meg3 is well conserved between rodents and humans allowing translational development. Oligonucleotide-mediated silencing of Meg3 in human cardiac fibroblasts and in vivo in mice resulted in decreased cardiac fibrosis and improved diastolic performance of the heart. Within MEGFIB, we now aim to advance these valuable research results on meg3-based improvements of cardiac fibrosis in mice towards commercial proof-of-concept. Important next steps are a) translation of the efficacy to human cells and tissues and b) sophisticated market analysis, c) IP strategy development and d) business development activities to maximize the value of the projects’ results. The outcome of our activities will be consolidated into a business plan for presenting our proposition to strategic partners, such as Cardior Pharmaceuticals or venture capitalists (VCs). We are proposing a unique RNA-based approach that offers a new opportunity to revolutionize medical practice, improve patient care and will reduce costs in the heart failure care.

Keywords: noncoding rnas,heart failure,new therapies