Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human-centric Digital Twin Approaches to Trustworthy AI and Robotics for Improved Working Conditions (AI4Work)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Germany,Italy,Finland,Greece,Portugal,United Kingdom,Netherlands,Belgium
Call: Large Scale pilots on trustworthy AI data and robotics addressing key societal challenges (AI Data and Robotics Partnership) (IA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 8197154.38
EU funding (EUR): 6818658.38
Participants: 18
Project status: SIGNED

AI4Work will investigate practical methods and tools for optimal sharing of work between humans and AI/robots. AI and robotics are likely to be most powerful means for radical improvement of working conditions in diverse domains, as they can support human operators in diverse tasks starting from difficult and tedious manual labor tasks up to complex decision-making tasks. The vision of the AI4Work project is to improve communication and collaboration between humans, AI and robots, allowing for an improvement of the working conditions within different processes in organisations in several domains in terms of increased efficiency of work, reduction in stress upon employees, increased confidence in decision-making process etc. Due to the high level of uncertainty in modern organisations an appropriate balance between human and machine activities must be found. The key assumption is that to cope with the required flexibility and dynamics, Sliding Work Sharing (SWS), where this balance varies during the operation depending on the situational context, machine-based confidence levels and human interactions, is likely to be the most appropriate for modern organisations. The key challenge of the project is to develop a set of common methods and tools (methodology framework, digital twin service platform, SW building blocks for SWS) that can be applied in diverse sectors and with different AI/robotics services, allowing for an effective experience exchange. The project will make use of living digital twins of working systems as a mean to increase efficiency and trustworthiness of AI/robotics solutions. By this, the project, aiming at improved quality of jobs and creating more decent work for human operators, will contribute to the acceptance of the AI/robots support of work in diverse domains. The project will be driven by six pilots in different sectors: logistics, manufacturing industry, construction, healthcare, education and agriculture.

Keywords: human centered ai,human ai robot work sharing,context sensitivity,digital twin,industrial ai
Light Induced Mechanical and multiphoton phEnomena in atomic arrays (LIME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: SIGNED

Atom-photon interactions are one of the most studied interactions in physics. These interactions are critical to the realization of several quantum technologies and the investigation of fundamental phenomena in many-body quantum physics. Yet controlling them at the quantum level in an efficient way is still one of the central challenges in contemporary physics. Subwavelength atomic arrays are emerging as a novel paradigm to realize efficient atoms-photons interactions. They are periodic arrangements of atoms with an interatomic separation smaller than their dipole transition wavelength. Atomic arrays harness dissipation as a resource, improving the control of atom-photon interactions over standard light-matter interfaces. However, most of the current theoretical and experimental effort has been devoted to the single excitation response of atomic arrays, thus neglecting the role of quantum correlations. Exploring these effects is timely as several experiments with subwavelength arrays can access this uncharted domain. This project aims at investigating the correlated many-body dynamics of subwavelength arrays and at studying their potential application in quantum technologies. Combining the fellow expertise in optomechanics, the US Host's deep knowledge of subwavelength arrays and open systems, and the EU Host's mastery of numerical methods for many-body physics, the goal of this research proposal is to establish subwavelength atomic arrays as efficient atom-photon interfaces and carefully model their experimental realization with atoms in optical lattices.

Keywords: open quantum systems,optomechanics,many body physics
Supervised morphogenesis in gastruloids (SUMO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Norway,Germany,Israel,United Kingdom
Call: Engineered Living Materials (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 3438217.68
EU funding (EUR): 3337725.0
Participants: 8
Project status: SIGNED

The lack of realistic in vitro organ models that can faithfully represent in vivo physiological processes is a major obstacle affecting the biological and medical sciences. The current gold standard is animal experiments, but it is increasingly clear that these models mostly fail to recapitulate the human physiology. Moreover, animal experiments are controversial, and it is a common goal in the scientific community to minimize the use of animals to a strictly necessary minimum. The emergence of stem cell engineered organ models called organoids represents the only viable alternative to animal research. However, current organoid technology is yet to produce the larger physiologically relevant organmodels that the medical sciences really need. Specifically, current organoids are too small, not vascularized and lack the 3-dimensional organization found in vivo. In this interdisciplinary project we aim to challenge all these limitations by using the recently developed gastruloid technology guided by cutting edge bioengineering and artificial intelligence. Gastruloids are formed by initiating the very early developmental processes and develops along a highly coordinated three axial process that closely resembles mammalian embryogenesis. Moreover, gastruloids can develop several organ precursors simultaneously and thus constitutes important improvements over conventional single-tissue organoids. To harvest the potential of gastruloid technology we will first implement large sequencing and imaging experiments to optimize the developmental trajectory of gastruloids for organ inductions. We will then build these datasets into a multimodal data matrix to identify gastruloid candidates for cardiovascular and foregut development. Specifically, we will identify candidates that show strong vasculogenesis as candidates for later vascularisation by anastomose with endothelial cells.

Keywords: gastruloids,artificial intelligence,closed loop system,organotypic modelling,microfluidic chips,multimodal imaging,raman spectroscopic imaging,microfluidics,interdisciplinary science
BIO-BASED LONG LASTING SAFE AND SUSTAINABLE BY DESIGN SURFACE COATINGS FOR DEMANDING AND EXTREME CONDITIONS (BLUECOAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: United Kingdom,Norway,Greece,Canada,Sweden,Italy,Belgium,France,Ireland,Austria,Switzerland
Call: SSbD bio-based coating materials for applications under demanding and/or extreme conditions (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 3503122.5
EU funding (EUR): 3503122.5
Participants: 17
Project status: SIGNED

Surface coatings are essential for protecting materials and enhancing their functionality, but the reliance on fossil resources necessitates safer, sustainable alternatives that maintain high performance while reducing environmental impact. To address these challenges, BLUECOAT will develop 12 safe, sustainable, bio-based, and low-carbon emission coating formulations for the marine, textile, and construction sectors that are challenging and demanding conditions for coatings. The project will explore 4 bio-based feedstocks: bio-derived polymers, natural fibres, bioplastics, and plant-based proteins, to develop 6 optimized coatings consisting of bio-based PU, bio-based silicone, PLA, natural fibres with antimicrobial agents (such as chitosan and curcumin), and encapsulates with Phase Change Materials (PCM). BLUECOAT formulations will cut GHG emissions by 45% and minimize Volatile Organic Compounds (VOC) while delivering superior performance under industrially relevant conditions (TRL 5). BLUECOAT solutions will provide antifouling and anti-corrosion protection for ship hulls, weatherproof, antimicrobial, and durable features for outdoor technical garments, and flame-retardant and antifungal for insulation boards in marine, textile, and construction sectors, respectively. The BLUECOAT’s vision is to establish a suite of comprehensive Safe-and-Sustainable-by-Design criteria guiding the development of bio-based coatings throughout their lifecycle, emphasizing circularity, energy and resource efficiency. The project will conduct the ex-post environmental assessment, techno-economic feasibility of scaling potential products, socioeconomic impact analysis for ensuring sustainable market adoption and long-term viability of the developed coatings. It will also explore End-of-Life strategies like biodegradability and recycling to extend material utility and support sustainable practices.

Keywords: safe and sustainable by design,bio based coatings,circularity,antifouling coatings,anticorrosion coatings,antimicrobial coatings,flame retardant coatings,thermoregulatory coatings
Bioactive reinforcing bioink for hybrid bioprinting of implantable bone (BioForceInk)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

3D bioprinting is an emerging technique that offers promise for fabricating implantable tissues. Despite significant advancements, the field struggles to replicate the mechanical robustness and biological complexity of native tissues, particularly in applications requiring high mechanical strength such as bone. This proposal introduces 'BioForceInk,' a bioactive reinforcing bioink designed for direct bioprinting alongside a cell-laden hydrogel within a cell-conductive environment. The microparticle-based bioink is printable at room temperature and solidifies at 37°C, forming a stiff, porous scaffold within the construct. Our preliminary studies demonstrated its excellent printability, mechanical properties, and osteoconductive capabilities in a hybrid bioprinting context. To enhance vascularized bone differentiation in vitro and support bioprinted implant integration and bone recovery in vivo, the bioink will be enriched with osteogenic and vasculogenic factors. Throughout this project, we aim to develop the growth factor-loaded BioForceInk and utilize it for creating vascularized bone implants by hybrid bioprinting in tandem with cell-laden soft bioink. We will then evaluate the regenerative potential of the bioprinted vascularized bone implants in a critical-size bone loss model. Additionally, we plan to test the technology with industrial partners and prepare it for commercialization by the end of the project. BioForceInk offers a unique combination of mechanical support and biological activity that facilitates the single-step fabrication of physiologically relevant bone implants. This innovation has the potential to significantly narrow the gap between bioprinting technology and clinical application, contributing to the development of personalized, mechanically robust, and biologically functional bone implants. With its tunable properties, BioForceInk could be further adapted for bioprinting of various tissues, reflecting its broad potential across the field.
Psychiatric partitions: the politics of mental illness in states of collapse (PSYPARTITIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1499832.0
EU funding (EUR): 1499832.0
Participants: 1
Project status: SIGNED

Psychiatric Partitions will transform our understanding of the relationship between politics and psychiatry in the twentieth century. Through its distinctive focus on the global phenomenon of partition – the practice of dividing and redistributing territory, population, and sovereignty – since the First World War, it will contribute the first systematic account of how questions around mental health and psychiatry mattered in these times of acute political and social crisis spanning decades and continents. Often described as ‘traumatic’, the psychiatric history of these cataclysms is more complex than trauma alone, encompassing tussles between departing and emergent states about responsibility for psychiatric populations; interventions by humanitarian organisations to prop up institutions and safeguard patients; the dilemmas faced by families around the care of unwell relatives. By identifying three cross-cutting research strands – responsibility, experience, knowledge – this project pioneers a framework for analysing the interaction between politics and psychiatry in times of crisis, and reimagines the history of partition from the perspective of a profoundly marginalised group: psychiatric patients. Interweaving archival and oral historical research into a carefully selected set of case studies across the century with longitudinal analysis of the history of international efforts to manage mental health in partition times, the project models an innovative contrapuntal approach to global history. Psychiatric Partitions matters not simply because it will drive forward the scholarship on partition, psychiatry, and global history, but because neither the legacies nor logics of partition thinking have left us today. It will allow for a fuller appreciation of the human stakes when partition is proposed and debated today, and sound a warning: that humanitarian interventions made in the name of care can end up implicated in the violent politics of population reordering.

Keywords: history of medicine,history of psychiatry,partition,population exchange,mental health,international humanitarianism,greece,turkey,india,pakistan,yugoslavia,serbia,croatia,bosnia and herzegovina
FantastiCOF: Fabricating and Implementing Exotic Materials from Covalent Organic Frameworks (FantastiCOF)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Portugal,Belgium,Switzerland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-11-01
End date: 2026-07-31
Duration (months): 45.0
Total project cost (EUR): 2383360.0
EU funding (EUR): 2383360.0
Participants: 7
Project status: SIGNED

Superconducting devices based on Josephson Junctions (JJs) are among the most versatile devices in superconducting electronics. Yet challenges remain because conventional JJs are created using a variety of materials that have been identified as a source of noise, dissipation and dephasing, and also, that raise compatibility problems during the fabrication process. FantastiCOF aims at developing a disruptive methodology to prepare exotic highly crystalline superconducting moiré materials, which will exceed the current challenges and limitations of existing materials and methods. Achieving this would represent an important step forward in the fabrication of low-noise JJ devices that will accelerate the development of the next generation of superconducting electronic devices with enhanced performance and sensitivity. FantastiCOF is an archetype of a perfectly balanced high risk/high gain project. It proposes visionary research to tackle the challenges in the synthesis of moiré materials and in the fabrication of low-noise JJs (ambitious and beyond the state-of-the-art), through the development of novel synthetic concepts (bottom-up) and the use of materials (2D covalent organic frameworks) with no precedents in the field, opening the door to a totally unexplored terrain (high risk), but providing tangible pathways towards achievements (solid risk assessment). The inherent high-risk is countered by a strongly interdisciplinary research team composed of 6 partners (5 academics + 1 SME) with different yet highly complementary backgrounds and demonstrated experience in their corresponding fields. Furthermore, FantastiCOF will have a high impact on a broad range of existing and emerging technologies that employ JJs (high gain), such as metrology, medicine, and quantum information technologies.
How the physical environment shapes the human brain (BrainScape)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1999600.0
EU funding (EUR): 1999600.0
Participants: 2
Project status: SIGNED

BrainScape constitutes a timely approach to study a widely unexplored aspect in the neurosciences, namely whether and how the physical environment that surrounds us day in, day out impacts our brain, well-being and mental health. BrainScape aims to spearhead the emerging field of Environmental Neuroscience and will make an impact by building a knowledge base for evidence-based urban planning to promote healthy living environments with significant practical implications. Given that our environment is undergoing rapid changes (urbanization, climate change), understanding how these changes may impact humanity is a crucial challenge of our time. First evidence suggests that long-term as well as day-to-day variations in exposure to solitary environmental factors (e.g. air pollution) may be relevant. The goal of BrainScape is twofold: (1) to identify the “active ingredients” of the environment by introducing a more holistic understanding of the environment, as a multi-layered complex phenomenon and (2) to gain insight into the pathways and mechanisms by which the environment affects the brain and mental health. To accomplish this, BrainScape will utilize existing large-scale cross-sectional and longitudinal neuroimaging data sets (UK Biobank, NAKO, HCHS, IMAGEN) to identify the most important features of the physical environment. These features will be at the core of prospective controlled studies, including a discordant monozygotic twin study. Here we will combine the assessment of objectively experienced (e.g., wearable sensors) and subjectively perceived environment with brain plasticity measured using 7 T MRI. The identification of the most influential environmental salutogenic features will inform a targeted intervention study and experiments in highly controlled lab environments using innovative VR technology combined with fMRI and fNIRS. The results will unravel the “active ingredients” of nature and the neural mechanisms by which they affect human beings.

Keywords: brain plasticity,environmental psychology,environmental neuroscience
An enhanced drug delivery system for brain cancer treatment which will be tested by human cell-based 3D in vitro microfluidic system (Enhanced-DDS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-08-31
Duration (months): 26.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: CLOSED

Cancer treatment by current clinical methods has many side effects, which result from the non-specificity of these methods. Moreover, treatment of some cancers, such as brain tumors, is extremely difficult because the brain barriers (blood-brain barrier (BBB) and blood tumor barrier (BTB)) prevents more than 98% of drugs from entering the brain. The use of stimuli-responsive nanomaterials for cancer therapy is more efficient than conventional ones due to access to targeting tissues, deep molecular targets, lower side effects, and controlled drug release. Mesoporous silica nanoparticles (MSNs) are widely used nanocarrier for drug delivery due to their unique physicochemical properties. However, the lack of consideration of the economic efficiency of MSNs synthesis, their surface modification methods, and the lack of use of physiologically relevant systems to test the efficacy and safety of MSNs, have caused that an effective and definitive cancer treatment method by MSNs has not been provided so far. In this project we aim to solve these problems and make the use of MSNs for therapeutic approaches realistic. The goal of this project is to develop a biosource-derived stimuli-responsive MSN for combined PDT/ chemotherapy of brain tumors to be evaluated in a physiologically relevant human cell-based 3D in vitro brain tumor microfluidic system. This project will be the first to investigate a combination therapeutic agent based on natural products modified with advanced plasma technology and evaluated in a novel human cell-based 3D microfluidic in vitro system that includes the BBB. Outcomes of this project will enhance the existing knowledge and technologies for MSNs’ synthesis, modification, and their cancer treatment performance evaluation, which will yield high-impact journal publications, as well as potential commercial product in the long term.

Keywords: drug delivery,stimuli responsive nanoparticles,biosources,cancer treatment,surface modification,dielectric barrier discharge plasma,microfluidic device design,organ on a chip,stem cell