Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel nanosized GDNF mimetics for the treatment of Parkinson’s disease: focus onto non-dopaminergic features (NeuroCure)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-08
End date: 2026-09-07
Duration (months): 32.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

PD is the most common age-related neurodegenerative disorder that is characterized by four pathognomonic hallmarks: 1) motor and non-motor deficits; 2) progressive loss of nigrostriatal dopamine neurons; 3) pathological aggregates of the α-synuclein (α-syn) protein; 4) neuroinflammation and oxidative stress. There is no single treatment currently available (or being tested) that can affect mechanisms of the disease, promote regeneration or at least protection of dopamine (and other affected neurons), and alleviate both motor and non-motor symptoms. Importantly, non-motor symptoms severely alter the quality of life of the patients since they are even more debilitating than the motor ones and do not respond to dopaminergic-based therapies. One of the therapeutically potent approaches to combat PD is neurotrophic factors (NTFs)-based therapies, particularly the glial cell line-derived neurotrophic factor (GDNF). GDNF demonstrated encouraging survival-promoting effects on dopamine neurons in diverse PD animal models and held a great hope as a neuroprotective treatment. Also, GDNF has positive impact in a number of other neurons such as sensory, enteric, olfactory, etc., which degeneration or dysfunction is associated with the appearance of non-motor symptoms. Despite of the promising results, GDNF due to poor tissue distribution and inability to pass through the blood brain barrier should be delivered to the brain through a risky surgery. To overcome the delivery problems and finally utilize the potential of GDNF in PD management proposed project combines neurobiology, translational biology, and experimental pharmacology to develop nanosized GDNF mimetic-based drug candidate that will 1) positively impact the disease progression through mitigation of the pathogenesis associated with α-syn aggregations and neuroinflammation, 2) support the survival of human dopamine neurons in vitro and 3) alleviate motor and non-motor symptoms of PD in vivo.

Keywords: parkinson s disease,alpha synuclein,neuroinflammation,glial cell line derived neurotrophic factor gdnf,small molecules
Objects of Contention: Art and Craft in the French Penal Colony of New Caledonia (ObCo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

In recent years, the creative practices of individuals subjected to various forms of captivity have become a vibrant field of study known as carceral aesthetics. However, despite the long and far-reaching history of penal transportation, the art and craft produced in penal colonies around the world have received little attention. My project, Objects of Contention: Art and Craft in the French Penal Colony of New Caledonia (ObCo), will contribute to these debates and offer new perspectives on the relationship between creation and oppression in colonial New Caledonia (1853–1946). Yet this research will not solely focus on the art and craft produced by some of the 30,000 common law prisoners, repeat offenders, and political prisoners transported to the Pacific archipelago in an effort to rid metropolitan France from its so-called dangerous class. It will also include the study of the creative practices of the Kanak, the Indigenous people of New Caledonia whose land France seized to establish the colony and whose history has typically been told in isolation. In addition to facing similar forms of detention, exile, and extractive labor, ObCo will show how the stringent control measures experienced by the Kanak and their progressive confinement to reservations expand the study of art and captivity well beyond the confines of the prison’ walls. In doing so, ObCo will not only fill a critical gap in the history of carceral aesthetics but also deepen our understanding of the historical conditions that fuel New Caledonia’s current waves of political and civil unrest. I will pursue this interdisciplinary research project under the guidance of Benoît Trépied, an anthropologist specializing in the history of citizenship in New Caledonia, in program co-led by Prof. Trépied called “Ethnography of domination: theoretical and methodological practices” at the École des Hautes Études en Sciences Sociales (EHESS) in Paris.

Keywords: penal colonies,prison studies,carceral aesthetics,pacific studies,anthropology,material culture
Renewable and Environmental-Sustainable Kit for building INtegration (RE-SKIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Italy,Spain,Netherlands,Luxembourg,Denmark,Bulgaria,Croatia,France,Austria,Belgium
Call: Cost-effective, sustainable multi-functional and/or prefabricated holistic renovation packages, integrating RES and including re-used and recycled materials (Built4People) (HORIZON-CL5-2021-D4-02, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 13162311.66
EU funding (EUR): 9615236.9
Participants: 21
Project status: SIGNED

The RE-SKIN project aims at developing an integrated and multifunctional system for energy retrofit of existing buildings, organised in two main subsystems, roof and façade, combined with the building's HVAC system. The roof is equipped with a hybrid photovoltaic-thermal system, which produces electricity and heat and at the same time thermally and acoustically insulates the slab beneath. Electricity, from retrofitted photovoltaic modules, powers the building's loads, which interacts with the grid and EV charging stations. Heat is used by a heat pump for heating and hot water preparation. Solar modules form the outer skin of the roof and replace traditional materials such as tiles and sheets. Through a special treatment, they can take on different colours, depending on the aesthetic and architectural identity of the building. The façade is a thermal cladding with self-supporting panels and bio-based insulation, optimised for quick assembly without scaffolding, inside which the wiring for the new installations and earthquake sensors are housed. Retrofit techniques/components of existing windows are also included. Both the roof and the façade are particularly resistant to weather and extreme climatic phenomena, as they use materials that are more resistant and waterproof than traditional ones. The HVAC system consists of a solar-assisted DC air-water heat pump, connected to smart-fancoils, which are designed to be connected to the building’s heating piping, but can provide both heating and cooling. The whole system is designed according to a circular economy logic, using mostly recycled/bio-based/repurposed/refurbished materials, and is supported by a lifecycle cloud-based DSS and energy management tool, in order to maximise energy performance while reducing environmental impacts. The system can be applied all over Europe, as it provides renewable energy and participates actively and passively in the energy performance of buildings, both in summer and winter.

Keywords: circular economy,resilient buildings,energy renovation,renewable energy sources,biosourced and recycled materials,refurbished and repurposed components,hybrid technical solutions
Advancing global SMEFT fits in the LHC precision era (EFT4ward)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

After more than a decade of data-taking, no direct evidence of new particles has been found at the LHC, suggesting that new physics (NP) might be heavier than the energies currently probed. Heavy particles can alter interactions among known particles, causing subtle deviations from the Standard Model (SM) predictions. The Standard Model Effective Field Theory (SMEFT) is a robust framework that allows for a model-independent parametrisation of new interactions, providing us with the tools needed for a successful indirect discovery program. In particular, the peculiar structure of the theory dictates correlations between different observables, motivating global analyses. In this proposal, I develop a strategy to advance global SMEFT interpretations in three key directions. Firstly, I will expand the comprehensiveness of the dataset by including low-energy observables in current global fit methodologies. To accomplish this, renormalization group equations mixing effects must be included in theoretical predictions, as they prescribe how different energy regimes are connected. Secondly, the research project aims to advance the design of optimal observables for global fits by using machine learning techniques, with the goal of maximising sensitivity to NP. Lastly, the ultimate objective of indirect searches is the identification of heavy new particles responsible for the modified interactions; the SMEFT is simply an intermediate step in this endeavour. I will provide the particle physics community with an open-source software that will interface with the output of global SMEFT fits and indicate which heavy particles are disfavoured by the data and which are still viable. The combination of my expertise in SMEFT analyses and collider phenomenology, along with the host institute's proficiency in advanced statistical methods, flavour physics, and UV matching, provides an ideal setting to successfully execute the proposed tasks and significantly advance indirect searches.

Keywords: collider phenomenology,effective field theory,global fit,machine learning
Developing a novel, biobased coating from agricultural waste and seaweed with high barrier properties and heat sealability for the production of single-use cups to displace and eradicate plastic cups (NO-PLASTI-CUPS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Italy,Spain,France,Portugal,United Kingdom,Sweden,Ghana,Finland
Call: Programmed biodegradation capability of bio-based materials and products, validated in specific environments (HORIZON-CL6-2024-CIRCBIO-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 4816789.51
EU funding (EUR): 4038686.05
Participants: 14
Project status: SIGNED

The NO-PLASTI-CUPS project is an industry-led consortium backed up by multi-disciplined academic partners which will develop a hydrophobic coating (‘the coating’) made entirely from biobased feedstocks (agricultural waste, seaweed and plants) which can be applied onto paperboard for conversion into disposable packaging focused on cups for hot and cold beverages (e.g. coffee or beer) as well as diverse applications such as takeaway containers for wet food e.g. soup. It brings together 14 organisations (businesses, universities, RTOs and NGOs) who cover all industry verticals involved in the production of coated packaging, alongside complementary academic and research expertise and an end user/purchaser, to ensure the required performance and sustainability profile of the end product as well as market fit. The coating and end products will have an evidenced biodegradation profile verifying that it biodegrades as programmed, is recyclable and home compostable and leaves no negative environmental impact in a range of real world settings. The process to manufacture the coating and products will be optimised in order to minimise inputs and achieve the carbon footprint targeted by the LCA. Behavioural research and intelligent design will improve understanding of consumer behaviour at end of life and upon disposal as well as demand for sustainable, renewable, natural packaging products. The working industry relationships required to advance the coating and packaging products to the industrial stage beyond TRL 5 will have been set in place by project end. The project will provide a concrete use case of the potential of the biobased, Green Economy in Europe and a model for the switch from fossil-based inputs and products to biobased inputs and products, tackling the growing problem of plastic packaging pollution by replacing them with truly circular, natural, biodegradable and recyclable packaging alternatives.

Keywords: packaging
Harnessing Hematopoietic Stem Cell Breakthroughs to Pioneer Advances in Transplantation Therapies (eHSCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Hematopoietic stem cell transplantation (HSCT) is a groundbreaking therapy that has transformed the treatment of severe hematological and immune disorders. It involves infusing healthy or corrected hematopoietic stem cells (HSCs) into a patient to restore their blood cell production. Despite its remarkable success, HSCT is currently limited to the most severe cases due to several key challenges. These bottlenecks include inefficient HSC mobilization, limited engraftment leading to insufficient clonal diversity, and the toxicity of chemotherapy-based conditioning regimens. This comprehensive proposal outlines a transformative approach to address these limitations head-on, enhancing both the efficacy and safety of HSCT. The project aims to: 1. Uncover the key factors governing HSC engraftment and egress: Using optimized genome-wide gain- and loss-of-function in vivo screening in HSCs, I will identify the pivotal players responsible for HSC engraftment and egress. These insights will inform the development of innovative mobilization strategies and the engineering of HSCs to confer a transient engraftment advantage. 2. Establish a mobilization-based conditioning regimen: I will exploit the temporary niche depletion induced by mobilizers to optimize a genotoxic-free regimen. By harnessing cell surface profiling data and potentially using mobilizer-resistant variants generated through directed evolution, I will tilt the competitive balance between freshly mobilized and infused HSCs, favoring the engraftment of infused cells. This project seeks to pioneer avant-garde methods that enhance mobilization and engraftment while avoiding the use of toxic conditioning regimens, thereby addressing major HSCT limitations. These advancements hold the potential to transform HSCT into a safer, more broadly applicable therapy, extending its benefits to a wider demographic and diverse healthcare settings. This aligns with the ultimate objective of achieving global health equity.

Keywords: hematopoietic stem cell,engraftment,transplantation,mobilization,chemotherapy free,conditioning,gene editing
Developing a web-based sexual health support program (AURORAS) for urogenital cancer survivors (AURORAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

Urogenital neoplasms, common in middle-aged patients, cause pelvic pain and sexual dysfunction. limited access to specialized services for urogenital cancer survivors (UGCS), necessitating alternative ways. Using a mixed-methods design and participatory design approach, this project will integrate 3 studies and aim to develop a web-based sexual health support program (WBSHP) based on survivors’ unmet psychosexual needs and to determine its acceptability, feasibility, and preliminary efficacy in managing pelvic pain and sexual function difficulties, ultimately intended to promote pelvic, mental, and sexual health and QoL in UGCS and their partners. Study 1 is a systematic literature review, following PRISMA guidelines, and will inform studies 2 and 3. Aims to summarize existing literature on online and e-mental and sexual health care services for promoting pelvic, mental, and sexual health of UGCS. Study 2 is a qualitative thematic analysis, conducted via in-depth interviews with a group of UGCS and their partners with maximum variation and focus groups with health care providers to explore the impact of UG cancers on survivors’ QoL and their unmet psychosexual care needs and to develop an evidence-based intervention program, integrated with the systematic literature review results, tailored to their needs. Study 3 is a pilot study assessing the acceptability, feasibility, and preliminary efficacy of a co-developed WBSHP intervention (AURORAS) among UGCS and their partners. Eligible participants, recruited from 3 research sites in Iran, after ethical approval, informed consent, and pre-test assessment will be randomized to either the experimental group receiving intervention (N = 30) or the waiting list group receiving treatment as usual (N = 30). Mid-test, post-test assessments, and follow-up at 3 months after program completion will be conducted. The waiting list group will receive AURORAS access and the same treatment protocol after 8 weeks of randomization.

Keywords: sexual dysfunction,urogenital neoplasm,neoplasm,cancer,pelvic,internet interventions
An Application for leveraging large-scale historical textbases (Histtext)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

HistText is a groundbreaking application developed to address the complex challenges of large-scale data mining in textual corpora, with a particular focus on historical documents. Created in the context of the ERC-funded ENP-China project, which aims to study the evolution of Chinese elites from the 19th century to 1949, HistText is the result of a synergistic collaboration between historians and computer scientists exploring machine learning applications for extensive text archives. Designed to manage databases containing billions of words across millions of multilingual documents, HistText offers a robust and versatile platform that streamlines the process of extracting and visualizing valuable insights. The application features a user-friendly interface, advanced text analysis techniques, and powerful data visualization capabilities. It provides a simplified approach for novice users to conduct complex data queries and analyses, while also offering a comprehensive R-library for more expert users. The main challenge that the proof of concept aims to tackle is to make HistText a fully packageable and transferable tool that can cater to the specialized needs of scholars and institutions holding vast digital repositories. With its focus on advanced text analysis and user accessibility, HistText stands as an invaluable resource not only for academics in the digital humanities but also for students and the general public. In terms of broader applications, HistText has the potential to be integrated into a wide range of institutions (libraries, digital content providers, etc.). The platform is exceptionally well-suited for analyzing a wide range of text genres, including newspapers, periodicals, directories, and diaries, among others. By offering a scalable, user-friendly, and methodologically rigorous tool, HistText aims to revolutionize how we approach large-scale textual analysis, providing a new pathway for understanding historical documents.
Diffractive Optical Element Fabrication based on 3D Printing (3D-Optics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Diffractive Optical Elements (DOEs) are used to shape the wavefront of incident light in complex patterns, and are ubiquitous across optical applications, ranging from laser processing through lithography to communication and imaging. Despite their popularity, fabricating DOEs is non-trivial, mostly due to their nanoscale-precision requirements, necessitating highly precise, expensive and cumbersome fabrication methods (typically using photolithography), which are also limited in the design flexibility they allow. During the PI’s ERC-StG, we developed a method to enable simple, fast, and high-quality fabrication of DOEs, by combining 3D printing with near-index matching by liquid-immersion. This results in DOEs comparable in performance to the state-of-the art, yet manufactured at a fraction of the cost and time. Still, at this point, these DOEs need to be immersed in a small liquid-containing chamber to operate, which prevents mass adoption of the technique by the market. Hence the main goals of this PoC: We will adapt our 3D-printing based near-index matching technique to yield fully solid DOEs, fabricate and demonstrate several proof-of-concept industry-relevant elements, and explore various strategies to bring our technique to the market. Our technology has the potential to transform the world of DOE fabrication by drastically simplifying the fabrication process, shifting the relevant scales from weeks to hours, from thousands of dollars to a few dollars per element, and finally – alleviating the need for a cleanroom environment, which will significantly democratize the process of DOE fabrication, making it available in low-resource settings.