Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TINY LIGHT ENGINE FOR LARGE SCALE LED LIGHTING (LEDLUM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Ireland,Austria,Ireland,Austria,France,Denmark
Call: Photonics KET 2016 (H2020-ICT-2016-1, 2016)
Start date: 2016-11-01
End date: 2020-04-30
Duration (months): 42.0
Total project cost (EUR): 4118521.25
EU funding (EUR): 4118521.25
Participants: 7
Project status: CLOSED

LEDLUM develops a highly integrated very cost competitive light engine technology platform for Solid State Lighting (SSL) connected directly to the electrical power grid. The new platform reduces size by 90%, material cost by more than 50% and losses by 20% compared to state-of-the-art solutions. Further LED-Drivers are the limiting factor for SSL Engines in reliability, lifetime and maintenance. The root cause is the electrolytic capacitor; whose removal is essential to increase the lifetime of LED drivers to match the LEDs (100.000 hrs). This is not practically possible with existing components and circuits, but combining the very high frequency (VHF=30-300MHz) technology with innovative energy-storage-concepts enable LEDLUM to achieve this. Based on this new VHF-approach LEDLUM uses embedding technology for both magnetic and capacitive components, hence enabling integration of light-source and driver/control-electronics on the same substrate. In 2020 the European LED-luminaire market will grow to €9B. and the corresponding LED-driver market to approx. €820M. LEDLUM addresses the size-driven and low-to-medium power luminaires with a potential of €90M. This will generate additional business and employees in Europe, as the LEDLUM-approach replaces the older technology made in other countries, which increasingly swash into Europe. The impact is even bigger if the European companies address the potential of €350M worldwide. To achieve these highly ambitious goals, LEDLUM unites leading players in the field of VHF, integration, LED-Driver and light-fixture-design from science and industry in a well-balanced and intensive collaboration. The drastic size reduction enabled by the innovative technology platform in LEDLUM is a direct response to the “Breakthrough in miniaturization of SSL light engines and systems” contained in the RIA of the ICT29 call. By developing the world’s smallest Light Engine, LEDLUM establish Europe as the world leading innovator in SSL solutions.

Keywords: switch mode power supplies,industrial lighting,monolithically integrated passive components,semiconductors
Cost Effective Wireless Electrical Transportation (CEWET)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Israel
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The multi-billion dollar public transit buses and train industry is under increasing regulatory and public policy pressure to adopt clean transportation solutions, that reduce CO2 emissions and noise pollution. ElectRoad has developed the technology that makes possible the first electrical vehicle that is directly powered by wireless energy with no need for a battery or costly infrastructure. This unique technology eliminates the need for fuelling or charging a battery to put an electrical vehicle in motion by removing the energy source from the vehicle and transmitting the power wirelessly directly from the road during the drive. The solution is generic and universal, can be used by all types of electric vehicles without any structural changes to the electrical vehicle. This technology is now at TRL level 6. ElectRoad has already achieved high energy transmission efficiency (above 80%), high value for money and zero emissions. ElectRoad electric buses are lighter (no battery), require less maintenance, and are more economical than electric buses of the competitors. The infrastructure is much cheaper than other electric transport alternatives such as trolleys or trams, making them attractive to public transport regulators, operators, and to the general public. CEWET will: – Perform a feasibility study in preparation for a full demonstration and pilot (planned for Phase II), including Business and commercialization Plans. – Prepare for the validation of the system on a road segment of approximately 200 m. - Perform a comprehensive Market Research and Risk Mitigation Plan – Prepare a Phase II proposal. Several stakeholders have been approached (Public Transport Operators, Municipalities, Government Authorities, Utilities companies, etc) and expressed enthusiasm about the breakthrough technology, as well as their readiness to participate in pilots and willingness to buy the product once in production.

Keywords: wireless,public transport,electrical vehicle,energy,emissions
Mechanisms of cellular fatty acid homeostasis (TGDNL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-01
End date: 2020-07-31
Duration (months): 36.0
Total project cost (EUR): 265059.0
EU funding (EUR): 265059.0
Participants: 2
Project status: CLOSED

The ability of cells to precisely maintain an internal steady state of lipids is essential for life. While homeostatic mechanisms controlling specific lipids such as sterols are well characterized, the regulation and coordination of fatty acid (FA) and triacylglycerol (TG) synthesis remains largely unknown. Several common metabolic disorders, including obesity and type 2 diabetes, lead to nonalcoholic fatty liver disease (NAFLD), a condition characterized by increased accumulation of hepatic TGs. Since a significant proportion of subjects with NAFLD develop potentially fatal complications, e.g. non-alcoholic steatohepatitis (NASH) and cirrhosis, it is of fundamental importance to study the mechanisms that promote hepatic lipid accumulation. By combining advanced molecular techniques with state-of-the-art clinical research, a translational approach will be applied herein to uncover how cells coordinate glycerolipid and FA synthesis. The studies focus on acyl-CoA:diacylglycerol O-transferase 2 (DGAT2), an enzyme catalysing the final step of TG biosynthesis and a drug target for NAFLD, which according to recent data may play an important role in FA synthesis regulation. The results generated in this project may uncover novel mechanisms controlling cellular lipid homeostasis and provide new therapeutic avenues to treat NAFLD and NASH.

Keywords: lipid metabolism,glycerolipid synthesis,de novo lipogenesis
Hyperpolarized Nuclear Magnetic Resonance Spectroscopy for Time-Resolved Monitoring of Interactions of Intrinsically Disordered Breast-Cancer Proteins (HYPROTIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 1990728.0
EU funding (EUR): 1990728.0
Participants: 1
Project status: SIGNED

HYPROTIN proposes a pioneering research platform for hyperpolarized magnetic resonance of breast-cancer related proteins that will revolutionize our view on tumorigenesis at the atomic level, through bottom-up reconstitution of medicinal relevant interaction pathways involving the breast cancer susceptibility protein 1 (BRCA1). The risk to develop a hereditary breast or ovarian cancer (HBOC) increases to 55-65 % upon mutation of the BRCA1 gene. Yet, little is known about the biochemistry of tumorigenesis, so that drugs directed towards molecular targets are not satisfactory. To date, mastectomy remains the only preventive treatment. This dramatic lack of knowledge is a consequence of BRCA1 being an intrinsically disordered protein (IDP). Recognizing the importance of IDPs has revolutionized structural biology in the last decade, but this also represents a huge experimental challenge. To date, nuclear magnetic resonance (NMR) is the only technique available to study IDPs at high resolution. However, several limits of the technique must be overcome. Its low sensitivity impedes investigations under biologically meaningful conditions, so that new approaches are required. The HYPROTIN project aims to achieve two methodological goals: 1) Residue-resolved studies of the BRCA1 IDP under physiological conditions; and 2) real-time monitoring of BRCA1-ligand binding, thereby adding a time-resolved dimension to the NMR characterization of IDPs. This systematic approach will provide unprecedented insight into the BRCA1 interactome, provide medically relevant data and residue-resolved protein interaction kinetics. This will open a new knowledge base for rational drug design. The project will employ cutting-edge equipment that is unique worldwide, and will represent the first facility in Europe suited for these ground-breaking experiments. The PI has unique interdisciplinary experience enabling the demanding hyperpolarization approach to IDPs.

Keywords: nuclear magnetic resonance,intrinsically disordered proteins,hyperpolarization,dissolution dynamic nuclear polarization,bottom up reconstitution of medicinal relevant biochemistry
Circulating Gender in the Global Enlightenment: Ideas, Networks, Agencies (CIRGEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-09-30
Duration (months): 69.0
Total project cost (EUR): 2499415.0
EU funding (EUR): 2499415.0
Participants: 1
Project status: SIGNED

Research on the role played by women as actors and by gender as a cultural category has crucially contributed to historiographical revision of the Enlightenment and its legacy to the modern world. However, the perspective adopted has been national or, if comparative, mostly radial. A leap forward is urgent because current circulationist approaches to the Enlightenment tend to forget its key gender dimension and to underplay contributions from Southern Europe. This projects offers, for the first time in the field, a systematic,truly transnational and transatlantic approach, which knits together cultural, intellectual, gender and postcolonial history, literary, philosophical and visual studies. It looks at the cultural transfer of gender notions in global perspective around five axes: translation, learned sociability, travel, reading and sensibility, to be explored through textual and iconographic analysis and archival research. Adopting the vantage point of Spain and its empire will allow to question approaches based either on the “national context” or the centre-periphery dichotomy, to reassess the role of the Catholic Enlightenment in the making of modernity and to highlight the mediating roles played by local actors, male and female, in processes of sociocultural change. CIRGEN’s specific objectives are: to challenge dichotomous visions of Enlightenment discourses of gender by stressing their plural (and often conflictive) contribution to modernity; to decenter customary radial perspectives by stressing multilateral dialogues both within Europe and beyond; to better understand the role played by gender in the cultural geography of Enlightenment, particularly in the construction of the South/North symbolic divide; to produce empirically grounded evidence of the practical and iconic role of women in the making of modern reading publics; to foster innovative scholarship on the gendering of emotions in defining national identities and moral standards of civilization.

Keywords: women,cultural transfer,translation,communication,hybridism,centres and peripheries,european south,transatlantic history,postcolonial studies,individual agency,sensibility,sociability
Metabolism of a cell pictured by single-cell approach (METACELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-07-01
End date: 2024-04-30
Duration (months): 70.0
Total project cost (EUR): 2330628.0
EU funding (EUR): 2330628.0
Participants: 1
Project status: SIGNED

Every cell is unique. Metabolites define the composition of each cell and play key roles in essential intracellular processes of energy production and uptake, signaling, regulation, and cell death. Obtaining metabolite signatures of individual cells and linking them to cellular phenotypes is of paramount importance for a holistic understanding of these processes. This requires high-throughput single-cell metabolomics that is not generally attainable due to the limited sensitivity, low throughput, and disruptiveness of state-of-the-art metabolomics methods. I propose to develop a spatial single-cell metabolomics approach for human cell culture systems. The approach will be based on using metabolite imaging mass spectrometry and will provide metabolite profiles of individual cells and metabolite signatures of single-cell phenotypes identified by light microscopy. With this approach developed, I will investigate the link between the intracellular metabolism and single-cell phenotype and focus on the following questions: How is the intracellular metabolism linked to cellular heterogeneity? How high is the variation of essential metabolites in a cell population? How do the energy metabolism and lipids biosynthesis change through the cell cycle and infection stages? What is the metabolic response to inflammatory signals? I will scale up the analysis to discover novel cell phenotypes both in the cell culture systems and in big metabolite imaging mass spectrometry data from various biological systems provided to us by our collaborators and the community, and representing billions of cells. My project will enable spatial single-cell metabolomics on a large scale and will provide yet lacking capacity for investigating and visualizing the intracellular metabolism on a single-cell level. It will advance our molecular understanding of key biological processes and pave the way to discoveries of molecular mechanisms of inflammation, cancer, and infection.

Keywords: single cell analysis,imaging,big data
Optimizing Bio-based Fertilisers in Agriculture – Knowledgebase for New Policies (LEX4BIO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Germany,Austria,Belgium,Finland,Hungary,Hungary,Bulgaria,Switzerland,Norway,Finland,Poland,Lithuania,France,Netherlands,Netherlands,Denmark,Denmark
Call: Closing nutrient cycles (H2020-RUR-2018-2, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 6000137.5
EU funding (EUR): 5999968.75
Participants: 23
Project status: SIGNED

Imported mineral phosphate and fossil energy-intensive nitrogen fertilisers cause major detrimental impacts on the environment, whilst nutrient-rich side-streams/organic waste remain under-utilised. By optimising usage of bio-based fertilisers (BBF) from side-streams, ensuring their safety, building evidence-based trust in their usage and developing legislative framework for their use, it will be possible to reduce dependence upon mineral/fossil fertilisers, benefiting the environment and the EU’s economy. LEX4BIO aims to achieve this by collecting and processing regional nutrient stock, flow, surplus and deficiency data, and reviewing and assessing the required technological solutions. Furthermore, socioeconomic benefits and limitations to increase substitution of mineral fertiliser for BBFs will be analysed. A key result of LEX4BIO will be a universal, science-based toolkit for optimising the use of BBFs in agriculture and to assess their environmental impact in terms of non-renewable energy use, greenhouse gas emissions and other LCA impact categories. LEX4BIO provides for the first time connection between production technologies of BBFs and regional requirements for the safe use of BBFs. The large variation between EU regions in nutrient flows and regional requirements for fertilisers will be estimated by harmonised methods to produce the knowledge basis needed to set up feasible ways to redirect the nutrient flows where needed. This will be followed by classifying the best available technologies for producing regionally tailored BBFs to secure high agricultural productivity, as well as environmental protection, food safety and human health. In LEX4BIO, the knowledge basis and recommendations will be gathered and processed together with stakeholders across Europe, providing best solutions for decreasing the dependency on imported fertilisers, closing the nutrient cycles and improving sustainability of European farming systems.

Keywords: policy requirements
Catching in action a novel bacterial chaperone for respiratory complexes (Chap4Resp)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2022-03-31
Duration (months): 78.0
Total project cost (EUR): 1999956.0
EU funding (EUR): 1999956.0
Participants: 1
Project status: CLOSED

Cellular respiration provides energy to power essential processes of life. Respiratory complexes are macromolecular batteries coupling electron flow through a wire of metal clusters and cofactors with proton transfer across the inner membrane of mitochondria and bacteria. Waste products of these cellular factories are reactive oxygen species causing ageing and diseases. Assembly and maturation mechanisms of respiratory complexes remain enigmatic because of their membrane location, multisubunit composition and cofactor insertion. E. coli Complex I, one of the largest membrane proteins, composed of 14 conserved subunits with 9 Fe/S clusters and a flavin, is a minimal model for its 45-subunit human homologue. When proton pumping by respiratory complexes is affected, bacteria become resistant to antibiotics requiring proton gradient for uptake. Based on the latest genetic data, we realize that the huge E. coli macromolecular cage, the structure of which we recently solved by cryo-electron microscopy (cryoEM), in conjunction with a novel protein cofactor, is a specific chaperone for Fe/S cluster biogenesis and assembly of respiratory complexes. This integrated multidisciplinary project combines cryoEM and other structural, biophysical and spectroscopic techniques, to uncover the functional mechanism of this emerging chaperone. The structural plasticity of the chaperone fuelled by ATP hydrolysis, and its interaction with Fe/S cluster biogenesis systems and the main respiratory complexes as a function of stresses, will be scrutinized to gain quasiatomic insights into the way the chaperone operates on its substrates. A novel technology for synergetic in situ investigation of protein complexes in the bacterial cytoplasm by optical imaging, state-of-the-art cryogenic correlative light and electron microscopy, and subtomogram analysis, will be developed and used to obtain snapshots of the chaperone-substrate interactions in the cellular context.

Keywords: cryo electron microscopy,correlative light electron microscopy,chaperone substrate interaction,assembly of bacterial nuo complex,bacterial iron sulfur cluster biogenesis
Atom-by-Atom Quantum Control of Fermions in Arbitrary Potentials (FermiTrap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The behavior of many-body quantum systems is one of the most difficult problems in modern physics. An interesting and open question is how the properties of a complex many-body system depend on its constituents, and how collective behavior emerges from the underlying few-particle building blocks. Ultracold atoms offer the unique possibility to realize well-controlled quantum systems and study this question directly in the laboratory. We propose a highly adaptable approach to assembling systems of few ultracold fermions in optical micro traps. Using a spatial light modulator, we will implement arbitrary trapping potentials and small optical lattices with novel geometries. A near-deterministic loading scheme will initialize states with extremely low entropies and realize previously inaccessible quantum states. We will perform detailed measurements of static and dynamic spin orderings on small Mott insulating plaquettes and realize unusual cylindrical optical lattices with periodic boundary conditions. Our approach is complementary to many traditional optical lattice experiments and will generate wide interest in mesoscopic Fermi systems.

Keywords: ultracold fermions experiment,arbitrary potentials,optical tweezers