Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Information Day for Hungarian students and young researchers on career possibilities in the European Research Area (CARERA)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Hungary
Call: ERA Mobility and Career Day (H2020-SwafS-2016-1, 2016)
Start date: 2017-03-01
End date: 2018-02-28
Duration (months): 12.0
Total project cost (EUR): 81483.75
EU funding (EUR): 81483.75
Participants: 3
Project status: CLOSED

The Hungarian higher education system is renowned for its excellence, both in technical and social sciences. However, many graduates do not find appropriate jobs in the country. Young researchers are often employed in poorly paid temporary positions with a low chance of finding stable employment in a reasearch institution. For them, information and assistance with European opportunities is crucial and can be instrumental in the continuation of their career as a researcher. The Association of Hungarian Women in Science – a Civil Society Organisation – together with EURAXESS Bridgehead Bay Zoltan Ltd. and the Central European University (CEU) will jointly organise a series of Inspiring Science Workshops and a large-scale ERA Mobility and Career Day in Budapest to enhance the career prospects of graduate students and young researchers from all fields of science. The events will be hosted by the partners with the latter taking place in the campus of CEU. Research organisations from several countries, international organisations and multinational companies will be invited to inform the participants on European research funding and career opportunities offered by them in a job fair format. Pre-arranged interactive meetings between the employers and potential employees will complement the fair. Practical workshops on career development (CV drafting, interview tactics, presentation skills), information sessions addressing the EURAXESS portal, career resources, personalized assistance tools to overcome the barriers of researchers’ mobility will maximize the knowledge of young researchers and students and help them starting a career in European research institutions. A workshop on Responsible Research and Innovation, with special regard to gender issues, will target all participants.The project will offer students and young researchers in Hungary better knowledge about European job and funding opportunities, and will contribute to providing more researchers for ERA.

Keywords: researchers career,young researchers,mobility
Interfacing interacting Rydberg polaritons: From few- to many-body interactions (InterPol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Rydberg quantum optics (RQO) is a very promising approach to achieve effective interactions at the level of individual photons. It maps the strong interactions between ultracold Rydberg atoms onto light fields to create strongly interacting Rydberg polaritons. RQO enables single photon generation, exotic photon bound states, and effective interactions between spatially separated photons. Based on RQO, various quantum optical devices can be implemented, e.g. a deterministic gate for optical quantum information processing. Experiments to date have mostly used 1D interaction geometries and not yet investigated interactions between more than 2 or 3 polaritons or in a quantum network of interaction nodes. InterPol will implement controlled interactions between multiple Rydberg polaritons based on two complementary approaches. One will cascade multiple devices such as single-photon transistors and subtractors to implement multi-polariton logic circuits and demonstrate a network that coherently interfaces entangled Rydberg excitations with photons for quantum state transfer. The second will use adaptive optics to realize a novel, highly flexible platform to study simultaneous interactions between multiple polaritons in arbitrary spatial geometries to study the transition regime from few- to many-body interactions. This has fundamental impact beyond quantum optics as it will allow highly controlled experimental tests of many-body interactions and non-perturbative effects in quantum field theories with quasi-particles in a tabletop setting. Collaborating with leading theorists to experimentally benchmark field-theoretical descriptions, the applicant will further deepen his theoretical understanding of RQO to complement his excellent experimental skills. In charge of a comprehensive research action, he will enhance his independence and possess the skill set required to develop and conduct innovative quantum optics experiments as an independent researcher at its end.

Keywords: rydberg non linear optics,rydberg atoms,quantum non linear optics,dipolar interactions,optical quantum information processing
Principles of Learning in a Recurrent Neural Network (LeaRNN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2350000.0
EU funding (EUR): 1635240.15
Participants: 2
Project status: SIGNED

Forming memories, generating predictions based on memories, and updating memories when predictions no longer match actual experience are fundamental brain functions. Dopaminergic neurons provide a so-called “teaching signal” that drives the formation and updates of associative memories across the animal kingdom. Many theoretical models propose how neural circuits could compute the teaching signals, but the actual implementation of this computation in real nervous systems is unknown. This project will discover the basic principles by which neural circuits compute the teaching signals that drive memory formation and updates using a tractable insect model system, the Drosophila larva. We will generate, for the first time in any animal, the following essential datasets for a distributed, multilayered, recurrent learning circuit, the mushroom body-related circuitry in the larval brain. First, building on our preliminary work that provides the synaptic-resolution connectome of the circuit, including all feedforward and feedback pathways upstream of all dopaminergic neurons, we will generate a map of functional monosynaptic connections. Second, we will obtain cellular-resolution whole-nervous system activity maps in intact living animals, as they form, extinguish, or consolidate memories to discover the features represented in each layer of the circuit (e.g. predictions, actual reinforcement, and prediction errors), the learning algorithms, and the candidate circuit motifs that implement them. Finally, we will develop a model of the circuit constrained by these datasets and test the predictions about the necessity and sufficiency of uniquely identified circuit elements for implementing learning algorithms by selectively manipulating their activity. Understanding the basic functional principles of an entire multilayered recurrent learning circuit in an animal has the potential to revolutionize, not only neuroscience and medicine, but also machine-learning and robotics.

Keywords: memory formation,memory updates,extinction,circuit mechanisms,dopamine,whole brain imaging of neural activity,drosophila,mushroom body
Toxin-antidote selfish elements in animals: from gene drive to speciation (TOX-ANT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1498428.0
EU funding (EUR): 1498428.0
Participants: 1
Project status: SIGNED

Toxin-antidote (TA) elements are a class of selfish elements that spread in natural populations by subverting the laws of Mendelian segregation (gene drive activity). For a decade, the only known TA element in animals was a paternal-acting element discovered in the nematode C. elegans. The lack of other examples perpetuated the idea that TA elements were extremely rare in animals. However, I recently challenged this view with two key findings 1) I genetically dissected a second TA element in C. elegans, the element sup-35/pha-1, and 2) I identified five novel TA elements in C. tropicalis, a close relative of C. elegans. Surprisingly, some of these novel TA elements can affect the fitness of adults and can antagonize each other mimicking the effect of balancing selection. Overall, my research strongly suggests that TA elements are much more common in animals than previously anticipated and raises critical questions about their origin, prevalence, mechanism of action, and contribution to speciation, all of which are largely unknown. This proposal has three main objectives: 1. To dissect the molecular mechanisms underlying an animal TA element for the first time. 2. To identify and characterize novel TA elements in diverse nematode species. 3. To screen for TA elements in medaka fish. My team and I will achieve these objectives by leveraging my multidisciplinary expertise in genomics, evo-devo, and biochemistry, as well as a state-of-the-art bulk QTL mapping method that I recently developed. Dissecting the molecular mechanisms used by natural selfish elements will help us design more efficient and specific synthetic drive elements that could target mosquito vectors spreading diseases such as malaria and Zika virus - global health burdens. I predict that we will discover and characterize many novel TA selfish elements in diverse species from nematodes to vertebrates. Our findings will stimulate new research areas in genetics, evolutionary biology, and medicine.

Keywords: gene drive,selfish gene,natural variation,speciation
Harnessing solid-state thermal cycling to Guide microstructure evolution of Additively Manufactured Metallic Alloys (GAMMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1499877.0
EU funding (EUR): 1499877.0
Participants: 1
Project status: SIGNED

Additive manufacturing (AM) holds the potential to revolutionize the alloy manufacturing sector through its ability to provide unprecedented control over the design of alloy microstructures during manufacturing. However, the main roadblock preventing its widespread adoption is the inability to design microstructures with desired mechanical responses. An AM process results in the formation of hierarchical microstructures that are extremely sensitive to the process parameters. Minor changes to these parameters can result in very different microstructures that exhibit significant differences in their mechanical response at multiple length scales. Controlling the mechanical response of hierarchical microstructures requires first understanding their formation during the AM process. Current experimental and modeling research efforts are heavily focused on studying the role of melt-pool dynamics and rapid solidification during the AM process. This project aims at tackling the crucial missing link, which is the microstructure evolution occurring during the long period after solidification and till the end of an AM process, i.e. during Solid-State Thermal Cycling (SSTC), at varying temperature rates and amplitudes. Using novel experimental procedures involving electron microscopy and x-ray synchrotron studies, I will quantify microstructural changes and identify micro-mechanisms caused by SSTC. This will be complemented with development of novel models at intragranular and polycrystalline levels to gain a comprehensive understanding of the role of transient thermal gradients on microstructure evolution. The experiment-modeling synergy will then be harnessed to tailor AM process parameters and suggest in-process/post-process routes to engineer AM microstructures. The approaches developed and the knowledge gained from this project will have far reaching benefits including, but not limited to, guiding emerging solid-state AM technologies such as additive friction stir.
THE VISUAL CULTURE OF SUFISM IN FRANCE AND GERMANY (SufiVisual)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Sufism, the mystical path within Islam, is spreading extensively throughout European society. However, despite its growing significance, we know little about the religious visual culture of ‘mystical Islam’ or Sufism, and no comprehensive study for the visual culture of Sufi orders in Europe exists, constituting a major gap in our knowledge. The proposed two-year research project SufiVisual will fill this gap. Combining anthropology, ethnography, religious studies, gender studies, and art history, the study will apply an innovative interdisciplinary approach to generate unprecedented insights into the visual culture of three key Sufi-based organizations. In combination these create a balanced case study in two research fields, France and Germany, which can be seen as paradigmatic for the European situation and beyond, narrowing the scope of the project so that it is feasible within the timeframe proposed while establishing a foundation for future projects to expand and build upon. The project will break new ground by being the first comprehensive interdisciplinary study on Sufi visual culture in a transnational context. It will produce pioneering work on gender-specific Sufi visual culture and contribute important scientific data on Sufi visualizations of belief and piety. The research findings will identify the ways in which visual culture actively constructs and shapes religious concepts and impacts our understanding of Islam, secularism, and European identity. A central working hypothesis of this project is that visual culture and religious practice is a counter movement to religious fundamentalism and a driving force for religious pluralism.

Keywords: sufismus,islam,visual culture,figural imagery,vision,image,iconoclasm,religious practice,mysticism,european identity,religious pluralism,fundamentalism,france,germany,piety,ritual
NON INVASIVE DIAGNOSTIC TEST SERVICE FOR “NON ALCOHOLIC FATTY LIVER DISEASE” MANAGEMENT (DeMILI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the project as a whole is to provide to the global clinical community a non-invasive diagnostic tool for the management of the NAFLD (Non Alcoholic Fatty Liver Disease) through an ON-LINE SERVICE OF DIAGNOSTIC TEST as alternative to Liver Biopsy. This project innovative approach is based on two verified proprietary imaging biomarkers linked to the evidence of NASH existence (Non Alcoholic Steatohepatitis) and fibrosis staging in patients with NAFLD, as well as a robust analytical method based on the optical analysis of a liver MRI (Magnetic Resonance Imaging) for the evaluation of these biomarkers. Currently, no validated non-invasive tests are available to differentiate simple steatosis from NASH. Unmet need for NAFLD management is the development of non-invasive methods able to detect NASH and predict advanced fibrosis in a cost-effective, immediate, widely available, and accurate way. This project faces a global unmet need and proposes a solution with ambitions of global scope based on a business and operational model that can afford this approach from an European perspective. With this proposal, Radiologists, Gastroenterologists, Hepatic doctors as well as primary care Doctors, will have access to an early screening of patients with NASH and therefore to an early and cost-saver approach to its treatment strategy, through an accurate on-line service of diagnostic tests based on a business model that anticipate a higher cost-effectiveness ratio compare to liver biopsy. Our feasibility assessment under Phase I work expect to validate that the business idea is achievable by the analysis of the technical and economic related aspects with the proposal and, at the same time, identifying those key issues to face in Phase II, jointly to the clinic validation and regulatory process necessary of being developed.

Keywords: liver diseases,nash,nafld,imaging biomarkers,steatosis,diagnostics,online services,diagnostic tests,dicom,liver biopsy,noninvasive,optical analysis,teleradiology
Aligning Research & Innovation for Connected and Automated Driving in Europe (ARCADE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Austria,Germany,Italy,Switzerland,Sweden,Finland,Greece,Belgium,France,France,France,France,Netherlands,United Kingdom
Call: Support for networking activities and impact assessment for road automation (H2020-DT-ART-2018, 2018)
Start date: 2018-10-01
End date: 2022-07-31
Duration (months): 46.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 26
Project status: SIGNED

The mission of ARCADE is to coordinate consensus-building across stakeholders for sound and harmonised deployment of Connected, Cooperative and Automated Driving (CAD) in Europe and beyond. ARCADE supports the commitment of the European Commission, the European Member States and the industry to develop a common approach to development, testing, validation and deployment of CAD in Europe and beyond. ARCADE involves 23 partners, 43 associated partners and over 500 subscribers, jointly forming the CAD network of European experts and stakeholders from the public, industry and research sectors, with international outreach. ARCADE uses a dual approach to identify and overcome bottlenecks and in parallel maximise consensus and synergy between stakeholders. Using a road metaphor, ARCADE focusses on “removing road blocks, paving the road, prevent traffic jams and providing navigation to a common destination”. In an annual cycle, ARCADE positions the CAD Network (WP2) centrally which brings together the CAD community at national, European and International levels. The Thematic Areas (WP3) work on content creation leading to consensus-based positions, needs and scenarios. The Knowledge Base (WP4) consolidates the CAD knowhow baseline and serves as public one-stop shop overview of CAD. The main results of ARCADE will be: · Knowledge Base on CAD regulations and policy, on organisations & projects, on standards, on testing methodologies & data and lessons learned · Scenarios, positions, gap analysis and recommendations on 12 thematic CAD areas · Updates of CAD roadmaps · Common Research & Innovation approaches across EU, US, Japan and other countries involved · Web and news flash promotion of national, European and international CAD activities

Keywords: network,knowledge sharing,exchange
Metal-Organic Hydrogels for Efficient Drug Delivery (MOHEDD) (MOHEDD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2023-04-30
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The treatment of glioblastoma – the most common, aggressive and lethal type of brain cancer with survival rated below 14% – requires novel and improved drug delivery systems to overcome the drawback of state-of-the-art local chemotherapy by using Gliadel wafers. MOHEDD aims to evaluate the feasibility of advanced nanoMOFs and hydrogel hybrids for controlled drug delivery into the commercial stage, with the idea of accelerating their access to the market as highly efficient delivery vehicles for glioblastoma. The novelty of MOHEDD’s technology lies on the synergistic potential of integrating nanoMOF particles, loaded with cancer drugs, within a hydrogel network to create a biocompatible, processible, tailorable system for efficient controlled drug delivery in glioblastoma. We use 3D sponge-like networks of hydrogels to promote the dispersibility of MOFs in their matrices, using the MOFs as high capacity drug vehicles as well as to tune the properties of the hydrogels. Through validation of drug loading and release with MOF@hydrogels, we will evaluate such composites for human (rat) glioma models. We expect to achieve pharmaceutical, clinical, academic and public impact throughout MOHEDD project by a close collaboration of industrial partners and clinical advisers. The industrial consortium stems from a successful spin-out of the academic group (Immaterial Labs), chemical manufacturers (BASF) and pharma companies (AstraZeneca) as well as clinicians. The success of MOHEDD will result in the translation of MOF@hydrogel systems to pharma industry through collaboration with Immaterial Labs.

Keywords: metal organic frameworks,adsorption technologies,drug delivery