Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery (PHOTO-FLUOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-09
End date: 2020-05-08
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The unique properties of the carbon-fluorine (C-F) bond explain why organofluorine compounds play a central role in biopharmaceuticals. One current challenge in drug discovery is the selective installation of C-F stereogenicity within the active site of lead candidates, such molecular editing may greatly help in increasing potency and understanding metabolic degradation paths. However, the limited C-F bond formation techniques complicate this approach and providing new versatile catalytic techniques, which can expand the substrate pool amenable to C-F bond formation, would greatly boost the impact of fluorine chemistry in drug discovery. We aim at developing methods that require feedstock materials as substrates, such as alkene and alkane derivatives. The new methods will combine the potential of enantioselective organocatalysis or metal-mediated processes with visible light photocatalysis. The PHOTO-FLUOR project is unique in that it provides training in “enantioselective fluorination” and “catalysis applied to drug discovery”, areas that contribute to European excellence. The resulting techniques may immediately impact the EU Health sector. PHOTO-FLUOR will merge the expertise of the host group in photochemical enantioselective reactions with the background of the applicant in transition metal catalysis, to reach the desired deliverables and milestones. In addition, a secondment at an internationally recognized pharma-company has been included in the work plan for conducting biological study of the fluorine-edited bioactive molecules. The applicant will transfer knowledge to both host groups creating a link between them to forge future collaborations. Finally, an ambitious training program, which includes a number of new scientific and soft skills to be transferred to the applicant, is also envisaged. The multi-cultural nature of this project will greatly broaden the fellow competencies and will place him in an excellent position for the next career move.

Keywords: organic chemistry,catalysis,enantioselective catalysis,photochemistry,transition metal catalysis,c f bond formation
HIstory and IMpact of NEUROimaging on SOCIETY (HI_IM_NEUROSOCIETY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The development of neuroimaging techniques, such as computed axial tomography (CAT scanning), functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), has been one of the major biomedical achievements of the past hundred years. These techniques allow the in vivo visualisation of the brain and gave new impetus to medicine, neurology, psychiatry, psychology, philosophy, economics and related fields by providing two unprecedented types of insight. Nations worldwide are making unprecedented investments in neuroimaging-related research: key projects include the European Human Brain Project, which is a H2020 FET Flagship Project (started in 2013, $1.2 billion), the US BRAIN Initiative (2013, $1 billion) and the Japanese Brain/MINDS (2014, $310m). Neuroimaging breakthroughs are making history, but the history of neuroimaging needs to be comprehensively assessed and the impact of neuroimaging on our society still needs to be properly defined. These are the key aims of this MSC Action, which is aimed at developing the first interdisciplinary platform worldwide on the history and impact of neuroimaging. Investigating neuroimaging in a historical perspective will fundamentally contribute to an integrated understanding of how neuroimaging has been shaping and is shaping biomedicine, culture and society. A critical history of the ways in which we see and study the brain is also crucial to increase the awareness about past and current research with neuroimaging, to involve the general public in a constructive debate about neuroscientific and societal challenges, and to promote a scientific culture about neuroimaging techniques and their applications.

Keywords: neuroimaging,neuroscience,history of neuroscience,history of neuroimaging,history of neurology,medical humanities
Teaming to Upgrade to Excellence in Environmental Biology, Ecosystem Research and AgroBiodiversity (BIOPOLIS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: France,France,France,France,Portugal
Call: Teaming Phase 2 (H2020-WIDESPREAD-2018-01, 2018)
Start date: 2019-10-01
End date: 2027-09-30
Duration (months): 96.0
Total project cost (EUR): 14988525.0
EU funding (EUR): 14988525.0
Participants: 11
Project status: SIGNED

The BIOPOLIS proposal of ICETA (Institute for Research in Agroenvironmental Sciences and Technologies), an institution from a Widening Member Country (Portugal), addresses the upgrade of its research unit CIBIO (Research Centre in Biodiversity and Genetic Resources) to a Centre of Excellence (CoE) for R&D&I, through a teaming with a leading scientific institution, the University of Montpellier (France), and with the participation of a business partner, the Porto Business School (PBS; Portugal). The proposal results from a successful application to the call H2020-WIDESPREAD-2016-2017, under the topic WIDESPREAD-04-2017. Rooted on an ambitious Business Plan, the project envisions to establish BIOPOLIS as one of the best international Centres of Excellence in Environmental Biology, Ecosystem Research and AgroBiodiversity, with the capacity for spreading excellence towards innovation in the areas of Environment, Biodiversity and Agriculture, and thereby contributing to socioeconomic development at the regional and national levels. The CoE will advance biological understanding from genes to ecosystems, and to use this knowledge to address pressing societal challenges through the development of world-leading research, the establishment of long-term strategic partnerships, the engagement of stakeholders, and the transfer and exploitation of research outputs. This will be achieved by attracting talented researchers, providing excellent conditions for research, training, internationalisation and networking, aligning research with societal challenges and smart specialisation strategies, engaging in ambitious advanced training programmes, developing strong communication, dissemination and exploitation activities, and setting a strong affiliates programme and other mechanisms to promote the translation of research and innovation into applications and business opportunities. BIOPOLIS will thus upgrade excellence in a widening country and promote sustainable economic development.

Keywords: new biology,omics based science,next gen sequencing,biodiversity,biomonitoring,ecosystem services
Stimulating effects of Future and Emerging Technologies through communication and outreach (FETFX)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Austria,Spain,Italy,Belgium
Call: FET-Open Coordination and Support Actions (H2020-FETOPEN-2018-02, 2018)
Start date: 2019-01-01
End date: 2021-06-30
Duration (months): 30.0
Total project cost (EUR): 699840.0
EU funding (EUR): 699840.0
Participants: 5
Project status: CLOSED

The strategic objective of the “FETFX - Stimulating effects in Future and Emerging Technologies through communication and outreach” project is to promote FET research among a wide range of actors (researchers and innovation community, policy makers, and general public) a through dedicated community building and multi-stakeholder engagement actions. FETFX proposes an innovative and customized communication and outreach strategy, based on the previous efforts made by the EFFECT project and taking advantage from the experience gathered by other Coordination and Support Actions, such as COFET and FEAT, funded under the FET programme in both FP7 and H2020. The FETFX communication activities will be based on the implementation of an innovative communication model, based on a content-centric and challenge-based approach. The FETFX project will be developed exploiting the connection with the former EFFECT project, based on novel and former communication channels (website and social media) and formats (different video formats, articles, news releases, multimedia storytelling, interviews), distribution mechanisms and contents classification. FETFX engagement actions will be implemented through different initiatives around the following key elements: (i) innovation potential (FET START Cup competition), (ii) communication potential (journalists in-the-lab), (iii) communication gaps on high-risk research (policy workshop and Recommendation Paper), (iv) engagement of the civil society (FETFX Photo Contest), (v) increase FET researchers communication skills (webinars and training sessions), (vi) foster the emergence of the FET community around its achievements (FET Day and Booklet). Thanks to its inclusive and creative approach, FETFX will stimulate the awareness and the engagement of a broader community around the mission-oriented scope of the FET Programme and the future and emerging technologies capable to renew European growth in terms of innovation and benefit for society.

Keywords: media communication,social media,stakeholders relations,public awareness,outreach,citizen engagement
From colloidal joints to reconfigurable matter (RECONFMATTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2023-01-31
Duration (months): 64.0
Total project cost (EUR): 1499956.0
EU funding (EUR): 1499956.0
Participants: 1
Project status: CLOSED

Self-assembly of colloidal particles has emerged as the most promising strategy to obtain fundamental insights into otherwise prohibitively complex systems as well as to create new functional materials from the bottom up. However, most self-assembled colloidal structures are static and thus limited in their functionality. Building on our recent discovery of colloidal joints, which enable a hinging-like motion between linked particles, I propose to unravel how such flexible bonds can be leveraged to obtain reconfigurable materials with unprecedented properties. I will investigate the impact of bond flexibility on the self-assembly, (multi-) stable configurations and phase behaviour of reconfigurable colloidal structures, and use these insights to create next generation materials that adapt their shape and thus functionality to external cues. To reach these goals, the project will consist of three work packages: 1) I will elucidate how bond flexibility can be exploited to create and understand reconfigurable structures. 2) I will unravel the phase behaviour and hierarchical assembly of flexible colloidal molecules. 3) I will introduce active and actuatable elements to control switching between different configurations and create shape-changing and self-propelled structures. Taking the concept of reconfigurability to the colloidal length scale will not only allow us to investigate the principles and consequences of structural flexibility on thermally excited objects, but also to develop the next generation of smart materials: materials with an adaptable shape and thus properties. These reconfigurable and actuatable structures have great potential for materials science and in biomedicine as they may feature switchable optical and acoustic properties, and ultimately could be employed in sensors, actuators, advanced coatings, and more complex functional devices such as micro-robots.

Keywords: self assembly,colloidal molecules,active matter,dna coated colloids,reconfigurable colloidal structures,patchy particles,colloidal crystals
Transcriptional controls over cerebellar neuron differentiation and circuit assembly (CERDEV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1499885.0
EU funding (EUR): 1499885.0
Participants: 1
Project status: CLOSED

The cerebellum is a critical regulator of motor function, which acts to integrate ongoing body states, sensory inputs and desired outcomes to adjust motor output. This motor control is achieved by a relatively small number of neuron types receiving two main sources of inputs and forming a single output pathway, the axons of Purkinje cells. Although the cerebellum is one of the first structures of the brain to differentiate, it undergoes a prolonged differentiation period such that mature cellular and circuit configuration is achieved only late after birth. Despite the functional importance of this structure, the molecular mechanisms that control type-specific cerebellar neurons generation, differentiation, and circuit assembly are poorly understood and are the topic of the present study. In my research program, I propose to investigate the transcriptional programs that control the generation of distinct subtypes of cerebellar neurons from progenitors, including Purkinje cells, granule cells and molecular layer interneurons (Work Package 1); the diversity of Purkinje cells across cerebellar regions (Work Package 2) and the postnatal differentiation and circuit integration of granule cells and molecular layer interneurons (Work Package 3). The general bases of the approach I propose consist in: i) specifically label cerebellar neuron progenitors and their progeny at sequential developmental time points pre- and post-natally using birthdate-based tagging, ii) FAC-sort these distinct cell types, iii) isolate these cells and identify their transcriptional signatures with single-cell resolution, iv) functionally interrogate top candidate genes and associated transcriptional programs using in vivo gain- and loss-of-function approaches. Together, these experiments aim at deciphering the cell-intrinsic processes controlling cerebellar circuit formation, towards a better understanding of the molecular mechanisms underlying cerebellar function and dysfunction.

Keywords: cerebellar development,single cell rna seq
New Approaches in the Conservation of Contemporary Art (NACCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Italy,Poland,Netherlands,Netherlands,United Kingdom,Portugal,Portugal,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 3812140.8
EU funding (EUR): 3812140.8
Participants: 10
Project status: CLOSED

The importance of European cultural heritage has been generally acknowledged. A significant part of this heritage, however, modern and contemporary art, runs a great risk of getting lost for future generations, because it is particularly difficult to preserve. Proper care requires resolving fundamental questions concerning the identity and authenticity of modern and contemporary artworks and the consequences for their conservation, rethinking historically grown professional distinctions as those between the curator and the conservator, re-organizing the institutional ecosystem, and establishing frameworks for international, interdisciplinary and intersectoral research and training collaboration. The aim of this Marie Curie Innovative Training Network is to educate a new generation of professional curators, conservators and academic researchers who are properly equipped to face these challenges. The key notion guiding the research and training programmes will be the notion of reflective practice. Starting from the theoretical framework of practice theory, the research programme will investigate conservation practices through the comparative analysis of their impact on modern and contemporary artworks’ biographies. The training programme will focus on the development of a reflective professional attitude, which is a pre-requisite in this increasingly complex and collaborative field.

Keywords: cultural heritage,contemporary art,conservation theory and ethics,reflective practice,authenticity,valuation,artist intentions,documentation,professional roles,stakeholders and audiences
Smart Energy Solutions for Africa (SESA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Germany,Germany,South Africa,Spain,Spain,Spain,Germany,Ireland,Germany,Germany,Norway,Tanzania, United Republic of,Sweden,Namibia,Sweden,Sweden,Netherlands,Kenya,Denmark,Denmark,Ghana,Rwanda,Morocco,United Kingdom,Malawi
Call: Accelerating the green transition and energy access Partnership with Africa (H2020-LC-GD-2020-1, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 10209987.5
EU funding (EUR): 9989133.13
Participants: 31
Project status: SIGNED

SESA will facilitate a structured co-development process, which starts with the co-development of energy access innovations that have a high potential for take-up and are tested, validated and later replicated. Each technology will be demonstrated in the living lab, and a corresponding information and training package is created. Each of the living lab team will consist of technology experts, local implementation partners (members of the consortium) along with local authorities (associated partners) and innovators (recruited through the seed-funding call), guided by business development, finance and policy experts. Demonstration actions will aim to test innovative technologies and services in different contexts that have a high level of replicability and a high potential for long-term sustainability. The project aims to achieve a high level of replicability of actions. As part of an effort to go beyond the state of the art and maximise the project?s impact, the project will co-develop innovations with local partners and cooperate closely with sister projects to exploit synergies. Solutions that will be tested in this project have been selected on their basis of their replication potential. Demonstration concepts aim to integrate several solutions to provide essential energy services to rural and urban communities and create easily replicable business opportunities for local entrepreneurs. The co-developed demonstration actions will be initially tested in the Kenya living lab and based on the initial learnings, various aspects of the tested innovations will be validated in living labs in different socio-economic operating environments (Ghana, South Africa, Malawi and Morocco). The learning from the validation living labs will strengthen the applicability and replicability of the technologies as well as the basic business concepts, which will be shared in the SESA toolbox and incubator programme.

Keywords: system integration,sector links
Thermocatalytic conversion of Cellulosic biomass to Furan-2,5-dicarboxylic acid (FDCA) over Single-atom based catalyst (Cell2Carbox)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2021-02-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 162040.32
EU funding (EUR): 162040.32
Participants: 1
Project status: CLOSED

Furan-2,5-dicarboxylic acid (FDCA) is a biobased product and an important chemical building block. It has a huge potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid. It is highly important for the pharma industry as it is being used in biopolymer industries to make polyesters, polyurethanes, and polyamides. Currently, avantium process is the only established industrial process consisting of the catalytic dehydration of carbohydrates to alkoxymethylfurfural (RMF) which is further oxidized to the sodium salt of FDCA using homogenous catalytic system. Using the homogeneous catalytic system for oxidation process followed by the alkaline solution for separation process makes the process more expensive and less eco-friendly. However, base-free systems lead to low yield and selectivity, therefore extensive research is required for exploring a new heterogenous catalytic system. Direct utilization of cellulosic biomass as a feedstock over the multifunctional heterogeneous catalytic system will improve the economic feasibility with optimized production technologies, as these are abundantly available at a low cost. I will achieve this goal by designing a multifunctional catalyst with the combined effect of acid, base and metal sites as a single atomic site. Cell2Carbox project aims to develop unique and sustainable catalytic processes for FDCA production from an inexpensive and highly abundant cellulosic biomass using multifunctional heterogeneous SACs (Single-atom based catalyst) system. Besides, the project comprises a program for my professional growth by training-through-research in heterogeneous catalysis and for the development of complementary skills. Strengthened by this experience, I will become independent expert in the process development for biomass valorization, as of major scientific importance in the coming decades as it is postulated in the EU Vision The circular bio-society in 2050.

Keywords: single atom based heterogeneous catalysis,cellulosic biomass,furan 2,5 dicarboxylic acid,bio based derived chemicals,chemical reaction kinetics,conversion process optimization