Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Performance Laser-based Additive Manufacturing (HIPERLAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Israel,Greece,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Photonics Laser-based production (H2020-FOF-2016, 2016)
Start date: 2016-11-01
End date: 2020-01-31
Duration (months): 39.0
Total project cost (EUR): 3756256.25
EU funding (EUR): 3756256.0
Participants: 9
Project status: CLOSED

HIPERLAM is an SME driven Research and Innovation Action (RIA) well-aligned to the Factories of the Future (FoF) Initiative with a strong emphasis upon demonstrating superior cost and speed performance in end-to-end processes featuring laser-based additive manufacturing in two key applications requiring high resolution printed conductive metallic lines, namely laser printed RFID antenna and laser printed Fingerprint sensors. Existing subtractive top-down process will be replaced by HIPERLAM’s additive process for both Applications. Process maps illustrate the existing multiple processing steps compared to HIPERLAM’s significantly fewer steps. Real-time diagnostics are included and Modelling investigations will be undertaken to support optimisation. The promise of HIPERLAM’s high resolution laser based additive manufacturing solutions is to transform the manufacturing processing speed by 10x for laser printed RFID antenna (Application 1) and 5x in the case of the lead-time for laser printed fingerprint sensor design (Application 2). Similarly, HIPERLAM promises to reduce costs by 20x and 50% respectively for Application 1 and Application 2. HIPERLAM features high resolution LIFT Printing and Laser Sintering utilising novel high viscous inks to achieve printed conductive metallic structures down to 10 µm resolution over large areas (10 to 1000 cm2) suitable for scale-up to full production. The targeted applications address global market needs and will support mainstream adoption of AM processes in EU industry by displacing existing processes with smart, flexible, digitally enabled manufacturing technology. HIPERLAM business cases promise significant revenue growth in both application spaces and in the potential for consortium partners to establish themselves in pre-eminent positions in high resolution, low cost, high throughput AM technology.

Keywords: laser based additive manufacturing,laser printing
Elimination of Senescent Cells Approach for treatment of COPD (ESCAPE_COPD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chronic Obstructive Pulmonary Disease (COPD) is estimated to affect up to 600 million people worldwide and by 2020 it will become the third most frequent cause of death. In Europe alone, COPD affects up to 10% of people (i.e. more people than breast cancer and diabetes) and it takes the life of around 300,000 Europeans each year. Current therapies are associated with a variety of side effects some of which can be acute and even life threatening. Moreover, none of the existing medications for COPD has been shown conclusively to modify the long-term decline in lung function thus, COPD remains a disease with a significant unmet medical need. Our approach is focusing on the pharmacological elimination of senescent cells (i.e. cells that have stopped dividing, but do affect their microenvironment) which accumulate in tissues with age and contribute to multiple age-related diseases, including COPD. In particular, we recently discovered that with the use of a particular molecule, we could efficiently target the molecular mechanisms that are responsible for the viability of senescent cells, leading to specific elimination of these cells from tissues. In turn, the goal of the PoC project is two-fold. (1) The first goal is to establish the technical feasibility of our idea by testing the effect of the identified molecule on the disease development and progression using the COPD mouse model we developed. (2) The second goal is to establish the business feasibility of our revolutionary approach by taking the necessary steps towards its commercialization, focusing on the creation of strategic alliances with key private sector companies.

Keywords: cellular senescence,lung,copd
Microstructured Topological Materials: A novel route towards topological electronics (MiTopMat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-12-01
End date: 2023-03-31
Duration (months): 64.0
Total project cost (EUR): 1836070.0
EU funding (EUR): 183607.0
Participants: 2
Project status: CLOSED

Topological semi-metals such as Cd3As2 or TaAs are characterized by two bands crossing at isolated points in momentum space and a linear electronic dispersion around these crossing points. This linear dispersion can be mapped onto the Dirac- or Weyl-Hamiltonian, describing relativistic massless fermions, and thus relativistic phenomena from high-energy physics may appear in these materials. For example, the chirality, χ=±1, is a conserved quantity for massless fermions, separating the electrons into two distinct chiral species. A new class of topological electronics has been proposed based on chirality imbalance and chiral currents taking the role of charge imbalance and charge currents in electronics. Such devices promise technological advances in speed, energy efficiency, and quantum coherent processes at elevated temperatures. We will research the basic physical phenomena on which topological electronics is based: 1) The ability to interact electrically with the chiral states in a topological semi-metal is an essential prerequisite for their application. We will investigate whether currents in the Fermi arc surface states can be induced by charge currents and selectively detected by voltage measurements. 2) Weyl materials are more robust against defects and therefore of interest for industrial fabrication. We will experimentally test this topological protection in high-field transport experiments in a wide range of Weyl materials. 3) Recently, topological processes leading to fast, tuneable and efficient voltage inversion were predicted. We will investigate the phenomenon, fabricate and characterize such inverters, and assess their performance. MiTopMat thus aims to build the first prototype of a topological voltage inverter. These goals are challenging but achievable: MiTopMat’s research plan is based on Focused Ion Beam microfabrication, which we have successfully shown to be a promising route to fabricate chiral devices.

Keywords: topological matter,dirac,weyl
Participatory Communication of Science (ParCos)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Belgium,Belgium,Finland,United Kingdom
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 1379772.5
EU funding (EUR): 1379772.5
Participants: 4
Project status: CLOSED

The main objective of ParCos is to improve science communication by creating participatory science stories that link to source evidence that the public can interpret for themselves to scaffold new science activities, and to deliver them through popular media forms of broadcast media and VR/AR technologies. The project will adopt a participatory approach in the creation of tools and methods to support citizens to take part in conducting, communicating and discussing science. Supported through the Bristol Approach, a framework that supports a people and issue-led process for citizen science and engagement, the project will explore issues such as a) ensuring diversity and inclusion in science participation and communication b) creating engaging stories for the public that both communicate and include the public in undertaking science activities and interpreting outcomes, and which account for different interpretations c). To support this, the project outcomes will be as follows. The ParCos Curator will support Open Science practices via methods for curation and re-use of science data. The ParCos Data Explorer and Storyteller will work together with arts-based methods to support participatory sense-making, interpretation and storytelling from data that can reveal a diversity of views and interpretations of the meaning in local contexts. The communication of stories alongside evidence will support the audience to judge the validity of evidence and interpretations, to find their own evidence and tell their own stories, using ParCos tools and methods to support them. ParCos outcomes will be evaluated through three distinct case studies, supported by the ParCos Trainer that supports learning of the methods and tools. Fostering an environment where evidence can be included and promoting the idea that it should be expected will make it harder for the voices of people who make unsubstantiated claims to dominate in public science discourse.

Keywords: science communication,curation,participatory sense making,participatory science stories,broadcast media,virtual reality,augmented reality
Transforming the hazardous waste of the metallurgical industry into a valuable raw material (ALSiment)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Iceland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The metal industry is generating every year millions of tons (Mt) of waste that in most of the cases is not re-used. Spent pot lining (SPL) is a waste material generated in the Al-smelting industry and has been classified as hazardous. For each ton of Al produced about 25 kg of SPL are generated and the Al- industry pays €520-1,560 million annually for recycling that waste with processes that do not bring much added-value. The ferrosilicon industry, whose annual production in 2013 was 8.1 million Mt is also generating an important amount of waste, mostly in the form of slag whose further treatment is both not optimized and expensive. On the other hand it appears the urgent need of minimizing the usage of cement as binding material (with the building industry as main consumer) due to the very severe environmental disadvantages: cement is the most produced and used raw material in the world with a global production in 2015 of 4.6 billion tonnes and it is responsible for 8% of the global CO2 emissions (3 billion tons of CO2 in 2015).Gerosion, an Icelandic SME founded in 2014, is finishing the development of Alsiment, an environmentally friendly cement-free binder able to bind SPL and other industrial waste, thus converting it into raw material valuable for energy-intensive industrial processes such as mineral wool production. With Alsiment Gerosion is supporting the metal industry to achieve their standards of sustainability by closing the material loop (re-use of all generated waste) while also enabling industries that currently rely on cementitious binders to reduce their use of cement.. Gerosion expects to obtain a cumulative revenue of €42 million in the period 2019-2021 achieving a 100% of the market share in Iceland and creating up to 11 new positions. This project is strategic for Gerosion as (i) it will position them at the centre of the Icelandic metal-waste recycling market, and (ii) it will boost their internationalization.

Keywords: hazardous waste from metallurgical industry,closing al and si cycle,environmentally friendly binder
Role of protein crystallization in type 2 immunity and asthma (ASTHMACRYSTALCLEAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2023-07-31
Duration (months): 60.0
Total project cost (EUR): 2499846.0
EU funding (EUR): 2499846.0
Participants: 1
Project status: SIGNED

Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitinase-like proteins Ym1 and Ym2, produced by alternatively activated macrophages. Here we challenge the current view that these crystals are just markers of eosinophil demise or macrophages activation. We hypothesize that protein crystallization serves an active role in immunoregulation of type 2 immunity. On the one hand, crystallization might turn a harmless protein into a danger signal. On the other hand, crystallization might sequester and eliminate the physiological function of soluble Galectin-10 and Ym1, or prolong it via slow release elution. For full understanding, we therefore need to understand the function of the proteins in a soluble and crystalline state. Our program at the frontline of immunology, molecular structural biology and clinical science combines innovative tool creation and integrative research to investigate the structure, function, and physiology of galectin-10 and related protein crystals. We chose to study asthma as the crystallizing proteins are abundantly present in human and murine disease. There is still a large medical need for novel therapies that could benefit patients with chronic steroid-resistant disease, and are alternatives to eosinophil-depleting antibodies whose long term effects are unknown.

Keywords: asthma,allergy,protein crystallization
Pre-leukemic B cell repertoire alterations in patients with familial chronic lymphocytic leukemia: looking for evidence of a genetically-inherited defect in tolerance induction (REPTOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

B-cell chronic lymphocytic leukemia (CLL) is a frequent B-cell leukemia of unknown etiology with the strongest familial inheritance among lymphoproliferative disorder. A key finding about CLL cells is that derive from autoreactive B lymphocytes, exhibit stereotyped Abs structures, and poly/auto-reactivity. Our long term goal is to prevent CLL by understanding the biology at the basis of CLL ontogeny. Our hypothesis is that an inherited CLL predisposition causes alterations in pre-leukemic B cells due to compromised immune tolerance, promoting, eventually, transformation event(s) that give rise to CLL. Such alterations skew the IG repertoires leading to enrichment of specific B- cell rearrangements with abnormal Ab reactivity. The overall goal of this study is to understand the role of inherited CLL predisposition in altering the IG structural repertoire and to determine the maturation step(s) and B-cell subset(s) at which these occur. Aim: Define a CLL-related BCR repertoire by analyzing the non-leukemic B-cells from patients with CLL. We will perform high-throughput BCR IG sequencing of non-leukemic B-cells of patients with familial and sporadic CLL. We will identify alterations in patient IGH repertoires compared controls to define a CLL-related repertoire. We expect to define an IGH repertoire difference in CLL patients that will result in the emergence of a mature B-cells with specific rearrangements normally not present. This approach to study CLL in a familial hierarchy diverges significantly from previous studies since it does not try to identify genetic alterations but focuses on structural and functional uniqueness of non-leukemic B-cells, we also avoid the background noise from the alterations specific for the leukemic clone. This study will unveil basic B-cell functional aberrations leading to the development of CLL, and its cellular origin, thereby providing the basis for the development of novel prevention and therapeutic strategies.

Keywords: immunoglobulin,repertoire,chronic lymphocytic leukemia,deep sequencing
A novel cost-efficient hydroponic technology to grow high value plant roots for nutraceuticals, pharmaceuticals & cosmetics (Rhizomia)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-03-01
End date: 2021-05-31
Duration (months): 27.0
Total project cost (EUR): 3150000.0
EU funding (EUR): 2205000.0
Participants: 1
Project status: CLOSED

Out of 391,000 plants known to science only 31,000 have practical applications. 18,000 are classified as medicinal plants, which means they have a documented medicinal effect. But only 150 plants are cultivated industrially. Medicinal plants are a huge global market, conservatively estimated at €70bn+ in 2015. Plant roots provide many of the important biologically active ingredients found in nutraceuticals, pharmaceuticals, cosmetics, food additives & other products. Production of such active ingredients from plants (cultivated by horticultural means or harvested in the wild) is not sufficient to meet the growing market demand. New sustainable production methods revolve around in-vitro cultivation in bioreactors. The main limiting factor of the current solutions is the plant biomass growth rate. Existing bioreactors are unable to produce sufficient amounts of biomass & active ingredients at economically attractive speeds, limiting their use. Rhizomia from Botalys is a novel technology that enables a 2x faster biomass growth (reaching doubling time of 6-8 days for ginseng roots) and a 2-3x boost in active ingredient elicitation level (10-12% concentration of the top 7 ginsenosides instead of 4% concentration of the top 7 ginsenosides in harvested wild ginseng). There is an annual market of ~80,000 tons of dry ginseng matter, growing at ~8% per year. It is dominated by non-European producers. With Rhizomia we are able to produce best-in-class red (post-processed) ginseng with unmatched profile of ginsenosides—active ingredients. With Rhizomia-produced ginseng we are aiming to take 30-35% market share already by 2030 by building a large-scale production facility and putting EU back on the map of major ginseng exporters.

Keywords: hydroponic technology,roots,in vitro,cultivation
Sewage Sludge to Oil Process (SSOP)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Israel,Germany,Spain
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-05-01
End date: 2019-10-31
Duration (months): 30.0
Total project cost (EUR): 2827977.5
EU funding (EUR): 1979584.25
Participants: 4
Project status: CLOSED

SSOP is a profitable green technology that transforms 95% of the solids of sewage sludge into fuel (oil + gas + char) and reduces the disposed sludge volume down to 5%. SSOP minimizes the environmental impact and disposal costs of the sludge and valorises this residue transforming it into a fully renewable source of energy (bio-crude). The users of SSOP (municipal WWTPs) will reduce their sludge treatment costs 75% (current annual operation expenses for SSOP are € 1 million for a 15,000 population equivalent/year plant whilst they are around € 4 million for conventional sludge disposal methods). Furthermore, the energy obtained will plenty cover the energy requirements of the plant (10%-30% of operation costs), leading to a global 50 % increase in profit thanks to savings. Our technology will also open a new business line for increasing profit: selling bio-crude.

Keywords: sewage sludge treatment,bio crude,bio oil,wastewater treatment plant,valorization of wastes