Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of Environmentally Friendly Flue Gas Purification Solution (DEFLUG)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Estonia
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The DEFLUG project will develop and commercialise a fully automatic flue gas filtration system for industrial and private customers. MyCapital OÜ in cooperation with its scientific, technical and marketing partners will introduce a very cost-effective and environmentally friendly flue gas purification solution that is based on the company´s patented substance. The substance can be mixed with regular pure water or seawater to form a purification dilution. The cleaning of flue gases is based on chemical reaction by which the flue gases will be purified from harmful substances like NOx, SO2, CO2, particulate matter, etc. The used dilution is completely harmful to humans and the environment. MyCapital´s innovative solution eliminates current problems with utilisation of waste filters and polluted water. In addition, the filtration system operates fully automatic and it has significantly lower life-cycle costs than all the alternative solutions at the market. MyCapital´s flue gas filtration systems are in first order commercialised to industrial boiler houses and large shipping vessels. Especially large market potential is seen at shipping industry. Today, of total global air emissions, shipping accounts for 18 to 30 percent of the nitrogen oxide and 9 percent of the sulphur oxides. Air pollution from international shipping accounts approximately for 50,000 premature deaths per year in Europe, at an annual cost to society of more than €58 billion according to recent scientific studies. Besides enhanced emission control of SO2 and NOx, the EU has committed to decrease maritime transport emissions 50% of 2005 levels by 2050. MyCapital´s solution main advantage over alternative technologies is that the used dilution can be directed straight into the sea, diminishing the need for costly utilisation of the wastes. The innovation is also easily scalable, being suitable for large variety of ships, other industrial applications and for private household´s heating systems.

Keywords: flue gas,purification,acidic gases,desulphurization,de nox,filtration
Modular Approach to Hybrid Electric Propulsion Architecture (MAHEPA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Slovenia,Slovenia,Netherlands
Call: Reducing energy consumption and environmental impact of aviation (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-05-01
End date: 2021-10-31
Duration (months): 54.0
Total project cost (EUR): 8979178.75
EU funding (EUR): 8979178.75
Participants: 10
Project status: CLOSED

The overall objective of MAHEPA is to bridge the gap between the research and product stage of a low emission propulsion technology to meet the environmental goals for aviation towards the year 2050. Two variants of a low emission, high efficiency, serial-hybrid-electric propulsion architecture will be advanced to TRL 6: the first uses a hydrocarbon fuelled internal combustion engine and an electric generator as primary power source, while in the second a hydrogen fuel cell is used to produce power showcasing the flexibility of the architecture. Common to both variants is the power control module, used to implement advanced power management methods to optimize mission, range and emissions of hybrid electric aircraft, and the new power electronic devices namely a highly efficient, airborne qualified electric propulsion motor and next-generation inverter technology. The modular approach is further demonstrated by integration and flight testing of each variant on a different small aircraft to showcase flexibility and scalability of the powertrain. A visionary implementation study towards commercial/transport category aircraft rounds up the project. The core value of MAHEPA is to build-up technological know-how and use flight test data to validate performance, efficiency and emission reduction capabilities of above technologies. This will allow to make conclusions about the suitability of these solutions towards megawatt-scale hydrocarbon driven hybrids and zero-emission hydrogen-powered solutions. For small aircraft this propulsion system development can be the door opener for a commercialized, new, low emission, highly efficient airplane category.

Keywords: hybrid electric powertrain,fuel cell,zero emission,aircraft electric powertrain components,hybrid aircraft,small electric hybrid aircraft
The role of danger signal and cellular competition in the elimination of B cells lacking the B cell receptor. (BCRdangerCOMPETITION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-10-01
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

B cells represent a specialized population of lymphocytes responsible for adaptive immune responses and life-long immune memory. All mature B cells carry B cell receptors (BCRs) on the surface and it is through the BCR that B cells recognize foreign antigens and subsequently provide antibody responses. Acute ablation of the BCR in resting mature naïve B cells in mice leads to a fast disappearance of Immunoglobulin negative (Ig-) B cells from peripheral lymphoid system. This phenomenon has been mainly explained by a “tonic” signal provided by the BCR, essential for B cell survival. However, there are at least two other possible, not mutually exclusive, mechanisms. In this proposal I hypothesize that i) loss of the BCR structure provides a “danger” signal leading to apoptosis of Ig- B cells; ii) Ig- B cells are eliminated as a result of cellular competition with the Ig+ B cells. I will test these 2 hypothesis by i) addressing the unfolded protein response (UPR) in Ig- B cells as a possible “danger signal” followed by in vivo genetic rescue experiments testing for its causality in Ig- B cell depletion; ii) I will produce pure Ig- B cell cultures, exploiting the novel system of genome editing of primary B cells, and address - in vitro and in vivo - the fitness, proliferation and differentiation capacity of Ig- B cells in presence and absence of cellular competition with Ig+ B cells. By addressing these points my work might provide a first-time evidence for the existence of “a danger signal” initiated in a B cell upon BCR ablation and prove its causality in Ig- B cell disappearance. On the other hand, elimination of Ig- B cells as a result of cellular competition with Ig+ B cells is a novel concept with important implications for lymphoma biology and potential clinical applications.

Keywords: b cell receptor bcr,immunoglobulin,cellular competition,unfolded protein response,crispr,cas9 mediated genome editing,in vitro derived germinal center b cells igb
TRANSversal Actions for Tritium (TRANSAT)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Fission/fusion cross-cutting actions
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Italy,Italy,Romania,Belgium,Romania,Slovenia,France,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Cross-cutting support to improved knowledge on tritium management in fission and fusion facilities (NFRP-2016-2017-1, 2016)
Start date: 2017-09-01
End date: 2022-02-28
Duration (months): 54.0
Total project cost (EUR): 5092616.1
EU funding (EUR): 3999259.69
Participants: 19
Project status: CLOSED

TRANSAT (TRANSversal Actions for Tritium) is a 4-year multidisciplinary project built to contribute to Research and Innovation on "cross-cutting activities" needed to "improve knowledge on tritium management in fission and fusion facilities". It proposes actions answering the following main challenges addressed by the call: i) tritium release mitigation strategies, ii) waste management improvement, iii) refinement of the knowledge in the field of radiotoxicity, radiobiology, and dosimetry. To evaluate the scientific tasks to be covered by TRANSAT, all the open issues of the tritium cycle that are not yet tackled by European research activities or former studies have been determined. This general picture has been constrained to crosscutting fusion and fission activities. Concerning release mechanism, tritium migration/permeation in massive samples are studied in dedicated rigs. Associated modelling takes place in the project in order to improve the level of confidence in predictive tools developed for tritium behavior in reactors. A special insight is also put in the release of tritium from tritiated particles coming from dismantling activities. Permeation barriers (active barriers and coating concepts) as well as treatment of the operational tritiated gases are assessed and their applicability to fusion and fission purposes is analyzed. Improvement in waste management is also covered by means of new concept studies for tritiated waste confining packages and by new accurate methodologies for tritium inventory assessment in metallic and soft house-keeping waste. Finally, a dedicated part of the project focuses on radiotoxicity, radioecology, radiobiology and dosimetry on tritiated particles produced during dismantling whose impacts have not yet been addressed. 18 Partners are participating in TRANSAT from all the European countries involved in tritium activities.

Keywords: tritium fission fusion
Random Graph Geometry and Convergence (RGGC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2021-04-30
Duration (months): 72.0
Total project cost (EUR): 1177905.0
EU funding (EUR): 1177905.0
Participants: 1
Project status: CLOSED

We propose an intradisciplinary research programme in pure mathematics, with graph theory at the epicenter and rich connections to other fields. Although the bonds between graph theory and other branches of mathematics have been growing in recent years, large parts of graph theory are still almost isolated from the rest of mathematics, and conversely, there are fields based on graphs that still make hardly any use of graph-theoretic machinery: the study of Cayley graphs in combinatorial group theory, the recent notion of Benjamini– Schramm convergence, and the many instances of approximating continuous spaces by graphs in various contexts are such examples. The RGGC project offers concrete graph theoretic approaches to important challenges in the afore- mentioned fields. At the same time, advances in graph theory using group theoretic and analytic machinery will be achieved. The project comprises 4 research Themes overarching a wide mathematical scenery. Theme 1 unites the worlds of Benjamini–Schramm convergence and graph minor theory using tech- niques from enumerative and analytic combinatorics that were applied for the first time in this context by the PI. Theme 2 builds on the deepest part of the PI’s past work to offer a new perspective to geometric random graphs profiting from a sophisticated theory triggered by Kesten’s random walks on groups. Theme 3 aims at deepening the understanding of cover time of graphs by exploring its extremal and typical behaviour using the concept of cover cost, an approach pioneered by the PI. Theme 4 introduces diffusions on continuous, graph-like spaces in the sense of Thomassen & Vella motivated by both theoretic and applied considerations. The proposed research not only attacks challenging questions in each of thease areas, it also creates bridges for transferring knowledge and tools among them, through concrete novel approaches of the PI that have already achieved initial success.

Keywords: random graphs,random walk,benjamini schramm convergence,cover time,diffusions
Unraveling the Photobehavior of Novel Mixed-metal MOFs for Efficient New Photocatalysts (MMOF4PPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-08
End date: 2023-07-07
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Research and development on high performance (in terms of stability and robustness) and conceptually innovative catalysts is essential to answer the increasing demand of sustainable chemicals and to achieve the European goal of energy consumption reduction, energy security improvement and competitiveness. In this regard multi-molecular catalyst with efficient electronic conductivity is emerging as a prominent research area. Mixed-metal metal organic frameworks (MM-MOFs) indeed exhibit excellent ability to deliver superior photocatalytic activity with improved temperature stability and robustness in harsh conditions, compared to homometallic systems. However, the understanding of these materials is still in its infancy. It is thus crucial to couple the synthesis of tailor-made multi-material systems with high-resolution characterization techniques and reliable surface science models, to obtain a deep understanding of emergent chemical and physical phenomena that are otherwise inaccessible with a single material catalyst. The main objectives and actions of MMOF4PPS will thus be to: (a) explore and optimize synthetic procedures for MM-MOFs, (b) decipher the ultrafast photo-processes inside MM-MOFs, (c) study the effect of varying ratio of metal clusters on the photocatalytic performance, (d) gain detailed knowledge of the effectiveness of MM-MOFs over single metal MOFs in photocatalysis and (e) develop structure–(photocatalytic) activity relationship. Such information represents a steppingstone for the optimization and acceleration in the development of sustainable catalysis, and is thus expected to have significant industrial and socio-economic impacts. In addition, both experienced researcher and host will benefit from establishing interdisciplinary research and deliver research excellence to academia and industry.

Keywords: mofs,photochemistry,femtochemistry,photocatalysis,laser spectroscopy and microscopy
Light-REsponsive Nanomachines for Targeted Eradication of BactErial Pathogens in LocaLised InfectIONs (REBELLION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-06
End date: 2023-04-05
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens. REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR. The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials. REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA). I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.

Keywords: antimicrobial resistance,infection,nanotechnology
COCOA In Vitro PROpagation (COCOAPRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Portugal
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In long-term, cocoa production is faced with serious challenges. Changing weather conditions, low and decreasing yields, ageing cocoa farmers, competition with other cash crops, volatile prices and pest-related diseases are threatening the future supply of cocoa. Around 4 million tonnes of cocoa beans are required each year just to keep up with current demand. About 500 million new cocoa plants (5%) are required each year. With demand for cocoa on the rise, cocoa production is set to receive special attention in the next few years. Micropropagation has emerged as an important global agro-technology routinely used for rapid generation of high quality, uniform and disease-free planting material. Boereboom Invitro Portugal is a SME specialized in in vitro plant micropropagation that will be pioneer in in vitro cocoa plants micropropagation worldwide, aiming at enhancing profitability and growth performance through innovative and competitive products seizing Europe and global markets opportunities. The SME can answer the increase on demand by presenting a maximum production capacity of 1 million cocoa plants and a net profit of €600,000, enable a corporate growth of a total net profit of €1,200 million by 2020. Boereboom already has a two years agreement with Theobroma, to whom will sell the product initially. Nowadays, the main commercial available solution for cocoa propagation is seedling. In vitro micropropagation offers several advantages over seed propagation, resulting in reduced costs, improved market access and sustainable increases of consumption. A competing solution to Boereboom’s product is cocoa plant propagation by somatic embryogenesis. However the application of this method is still in a development phase. Boereboom’s team has the relevant know-how to implement the business, having created a project management structure that can ensure a competent management and a solid integration and communication throughout the whole project lifecycle.

Keywords: in vitro,micropropagation,eu cocoa market,profitability,sustainability
“Tracking nano-bioprocesses using Super-Resolution Microscopy Techniques” (NANO-SUPREMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Italy,Italy,Cuba,Czechia,United States,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 873000.0
EU funding (EUR): 724500.0
Participants: 7
Project status: CLOSED

Long-range research and innovation goal: The long-range goal of Nano-Supremi is to develop case studies to enable the advanced super-resolution microscopy to investigate nanoscale synthetic and biological structures and to probe nanoscale dynamic processes. Long-range biomedical research and technology goal: The implementation of Nano-Supremi will allow for tracking nanometer-scale bioprocesses such as (i) nanomedicines cellular uptake and trafficking and (ii) single-molecule dynamic processes of DNA-protein, (iii) protein-membrane interactions. Key Research Goals: The objective of Nano-Supremi is to turn the following creative research ideas into advanced microscopy technologies and services. This will ultimately results in the evaluation of in vitro protein and DNA activity and therapeutic efficacy of nanomedicines plugging the gap between innovative research and its exploitation in clinical setting. Scientific impact: We identified a few innovative case studies to explore the potentiality of super resolution microscopy techniques in solving nanoscale bio-structures and dynamic processes. Impact on early-stage researchers: Nano-Supremi involves key participation of junior researchers with outstanding record of achievements in education and research, providing strong support for the development of their careers. Intersectoral dimension: A synergistic approach in using advanced technologies developed by microscope manufacturers to answer fundamental and applied questions on bioprocesses will be pursued. Interdisciplinary dimension: A complementary research program, ranging from nanophotonics, materials science, to molecular biology and bio-analytical chemistry, will drive the implementation of research tasks towards the full achievement of the objectives. International dimension: Funding of this program will enable long-term, transformative research collaborations between groups settled in European Countries and in four non-EU Countries (AU, US, Brazil, Cu)

Keywords: super resolution microscopy,dna switch,trascriptiom factors,nanomedicine,stem cells