Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY (AFFECT-EU)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Ireland,Italy,Australia,Germany,Ireland,Spain,Germany,Norway,Serbia,Sweden,Sweden,Sweden,Switzerland,Finland,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Canada,Denmark
Call: Towards risk-based screening strategies for non-communicable diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-03-31
Duration (months): 51.0
Total project cost (EUR): 8028631.25
EU funding (EUR): 5947925.0
Participants: 26
Project status: SIGNED

Atrial fibrillation (AF) is an increasingly common arrhythmia in the aging European population. Its prevalence will more than double by the year 2050 affecting 5% of EU women and men aged ≥65 years. AF carries a high risk of stroke, heart failure, and dementia, which result in a significant loss of quality-adjusted life years and high mortality. The EU guiding principles for active aging (no. 17468/12) recommend disease prevention to maximise healthy life, and early detection of AF is recommended by the European Society of Cardiology (ESC). Nonetheless, to date, a risked-based screening strategy is lacking. AFFECT-EU’s major goal is the development of a risk-based, accurate, and ready for implementation AF screening algorithm, using digital devices, for early AF detection in the community. For this objective we will (1) Develop a risk-based AF screening algorithm, by combining the available information from the largest outcome trials (Danish LOOP, STROKESTOP, SAFER) and multiple screening studies across Europe (Ntotal>100,000) including health modifiers and biomarkers; (2) Refine the stratification of high-risk populations in a personalised approach through exploration of distinct digital screening methods and multiple health determinants in deeply-phenotyped population cohorts; (3) Validate the AFFECT-EU risked-based screening recommendations in a meta-analysis of European and world-wide studies; (4) Demonstrate cost benefits and acceptability of AF screening across different European healthcare systems; (5) Identify the AF screening potential to be taken up by differing healthcare systems; (6) Foster the dissemination of results and adoption of the risked-based AF screening algorithm in the ESC (an AFFECT-EU partner) guidelines. AFFECT-EU will develop the first targeted, risk-based AF screening algorithm, and thus contribute to the reduction of AF-related health inequities, morbidity and mortality in Europe.

Keywords: atrial fibrillation screening,stroke prevention,biomarker,risk stratification,digital screening,health determinants,population health outcomes
Explore the potentialities of biostealth coatings for tissue engineering and reconstructive medicine (BioStealth)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

BioStealth production of implant coatings provides an exciting business opportunity. BioStealth offers unique advantages of societal and economic importance, such as public health and sick leave. Biocompatible materials, i.e. materials with proper cell response upon implantation, are attractive for restoring body function. Conventional implant coating methods lack in quality and therefore the majority, if not all, bio-coatings fail in proper interaction with host tissue, either caused by absence of biological triggers, biofouling or unwanted chemistry. This lack of proper interaction occurs fast upon implantation and disturbs specific cell interaction, eventually causing infections. Mostly, patients need rehospitalization which increase health care costs. BioStealth produces easy and cheap implant coatings by dipping or spraying lipids. BioStealth lipid coatings are air-stable and suitable for in-vivo use. BioStealth can be applied to FDA approved implant materials without changing the mechanical properties, which is key for tissue engineering and reconstructive medicine. BioStealth coatings have a tunable composition which makes them an ideal coating to improve interactions with cells. These factors greatly enhance application potential. Non-fouling lipids were suggested before, but as hydrogels are used for preconditioning implants, air-stability, fast procedures, tunable capability and the range of materials that can be coated and used in-vivo is very limited. In BioStealth innovative, robust conditioning of implants with plasma is used for lipid attachment, creating a breakthrough in integration of implants with tissue. A business case will be developed for BioStealth, covering different markets and routes for market introduction. Results of market analysis and financing needs will be combined with science-based technology comparison and used for discussions with potential industry partners. Several companies have already expressed interest in BioStealth.

Keywords: biological coatings
Support to the Vice-Presidents of the ErC Scientific Council 2015 (ERCSC-VPRES-SUP2015)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Spain
Call: European Research Council (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2015-12-31
Duration (months): 12.0
Total project cost (EUR): 276125.0
EU funding (EUR): 276125.0
Participants: 1
Project status: CLOSED

The proposed Action will provide the necessary support to the Vice-Presidents of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required under the Horizon 2020 framework programme.

Keywords: erc vice president support
Thermal Energy Storage Systems for Energy Efficient Buildings. An integrated solution for residential building energy storage by solar and geothermal resources (TESSe2b)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Austria,Cyprus,Greece,Greece,Greece,Poland,Greece,United Kingdom,Portugal
Call: Integrated solutions of thermal energy storage for building applications (H2020-EeB-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 4311700.0
EU funding (EUR): 4311700.0
Participants: 11
Project status: CLOSED

There is a compelling need of encouraging energy efficiency in buildings, enhance green technologies and promote advance thermal energy storage solutions. TESSe2b will enable the optimal use of renewable energy and provide one of the most advantageous solutions for correcting the mismatch that often occurs between the supply and demand of energy in residential buildings. The target of TESSe2b is to design, develop, validate and demonstrate a modular and low cost thermal storage technology based on solar collectors and highly efficient heat pumps for heating, cooling and domestic hot water (DHW) production. The idea is to develop advanced compact integrated PCM TES tanks exploiting RES (solar and geothermal) in an efficient manner coupled with enhanced PCM borehole heat exchangers (BHEs) that will take advantage of the increased underground thermal storage and maximize the efficiency of the ground coupled heat pumps (GCHP). The two TES tanks developed within TESSe2b project will be integrated with different PCM materials; (i) enhanced paraffin PCM, (ii) salt-hydrates PCM, while in both of them a highly efficient heat exchanger will be included. Even if the concept of phase change thermal stores has been demonstrated, TESSe2b project discriminates itself through incorporating; (i) PCM materials innovation, (ii) advanced energy management through self-learning model-based control system, (iii) enhanced PCM BHEs (v) compact modular design of thermal storage tank. Since the lifetime of TESSe2b solution is among the most critical factors determining its acceptability, reliability and success the on the long run, special emphasis will be given in the life-expectancy of the involved components.

Keywords: thermal energy storage,energy efficient buildings,solar energy,geothermal heat pumps
'Total E-field Reconstruction using a MIchelson TEmporal Scan' for spatio-temporal metrology of ultrashort laser beams (TERMITES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The technology of femtosecond lasers now makes it possible to reach enormous light intensities with only moderate amounts of energy. These so-called Ultra-High Intensity (UHI) lasers have led to the development of a very active research field, which studies the interaction of light with matter at these extreme intensities. This field is largely motivated by the prospects of generating compact sources of high-energy particles and short-wavelength light, which are being foreseen for applications in particle physics, material science, nuclear fusion technology, medicine. The actual feasibility of the promising applications of UHI lasers will largely depend on the availability of more reliable and controlled laser systems. In this context, the recent results obtained in the framework of the ERC project PLASMOPT have shown that both major obstacles and great prospects towards this goal are related to space-time couplings (STC) – i.e. a spatial dependence of the laser pulse temporal structure. Yet, there is still no device capable of measuring these STC. The goal of the present project is thus to bring up on the market the first STC measurement device, called TERMITES. This will allow identifying the source of the residual STC, and then eliminating them to reach optimal performances, thus reducing the cost needed to reach a given laser peak intensity by hundreds of k€ or more. It will also have indirect societal benefits, by contributing to the maturation of the technology of UHI lasers, and thus favouring their foreseen societal and industrial applications. Two key tasks of this project are 1- building two to three industrial demonstrators of TERMITES and 2- using these demonstrators to perform a test and validation campaign on a representative set of fs lasers. Depending on the findings of this campaign, this device will be commercialized either through a technology transfer through licensing to an existing company, or through a start-up creation.

Keywords: optics,ultrafast optics,metrology,ultraintense lasers,femtosecond lasers,interferometry,fourier spectroscopy
Savanna water and carbon fluxes modelling integrating Earth Observation data (SWATCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2018-02-01
End date: 2021-01-31
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

The aim of SWATCH is to develop a unique information system for quantifying savanna water use and biomass production on a regional scale, with the ultimate objective of supporting decision-making processes. This effort directly addresses the European H2020 priorities of sustainable rural development and food security. Savannas are among the most complex, variable and extensive agrosilvopastoral systems on Earth (~20%). One fifth of the world's population depend upon them, although they are extremely vulnerable to changes in land use and climate. These changes affect not only ecosystem functioning, but also the land-atmosphere linkages and regional carbon cycle, in ways still unknown. Since savannas are greatly influenced by human activities, private/institutional practices play a key role in their conservation. The integration of Earth Observation data into process-based models will enable us to map the evolution of the ecosystem health, improving their management, productivity and resilience. However, to map savanna fluxes, besides the mechanistic understanding of how the climate (dry periods) and the canopy structure (patched multiple canopy layers) interact with land-atmospheric processes, robust techniques to upscale the ecosystem parameters and fluxes over space and time are needed. This project intends to bridge this gap and contribute to: 1) a better mechanistic understanding of savanna water/energy/carbon fluxes, using long-term eddy covariance and ground measurements 2) more accurately modelling these fluxes on a regional scale with different-scale EO data 3) the development of an operational information system to be integrated into decision-making processes, evaluating a pilot experience located over dehesa (Spanish productive savanna).The outgoing phase with Prof. Baldocchi's group (UC Berkeley, USA) intends to cover first and second objectives, while the third one will be address on the return phase, with Dr. Gonzalez-Dugo's group (IFAPA, Spain).

Keywords: environmental science,ecosystem modelling,water and carbon fluxes,savanna ecosystem,food security
NORmalize MusculoskeletAL LOadings to Avoid bony Deformities in children with cerebral palsy (NORMAL-LOAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Muscle contractions in children with cerebral palsy (CP) cause abnormal musculoskeletal loading, which can lead to bony deformities. Deformities of the femur are commonly corrected by de-rotation osteotomies. In children, early clinical interventions, which aim to normalize the loading of the musculoskeletal system, could influence bone growth and prevent the development of bony deformities. To investigate this assumption, I will use musculoskeletal (MSK) models to calculate the loading conditions of the femur before and after Botulinum Toxin-A injections (BTI) in lower limb muscles. The obtained loading conditions will then be used as input for a mechanobiological finite element analysis (FEA) model to assess the impact of altered loading conditions on femoral bone growth. With this simulation platform, I will use the patient’s gait pattern and BTI treatment history to relate the loading conditions to the femoral deformities and compare these to the measured deformities from medical images. If BTI or similar load-modifying clinical interventions can be used to reduce the number of surgical corrections, it will decrease the burden on the child as well as decrease the socio-economic costs related to the treatment of children with CP. During my PhD at Griffith University (Australia), I compared different methods and models for clinical gait analysis and showed that MSK models can be confidentially used in children with CP. With this project, I strive to go one-step further and show that MSK loadings in combination with a mechanobiological model can be used to enhance our understanding of the impact of clinical interventions and, therefore, improve the treatment planning in children with CP. I am highly motivated to take on the challenge and acquire the new scientific and transferable skills, which will strengthen my profile for future grant proposals and increase my opportunities for a permanent position after the fellowship.

Keywords: biomechanics,musculoskeletal modelling,gait analysis,multi body simulations
Cloud-based Visibility Service for Software Defined Networks (SDN-Polygraph)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-10-31
Duration (months): 7.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today, enterprises depend on the Internet and computer networks. Costs associated to network malfunctions are huge, estimated around 30K€/hour; companies average 175 hours of downtime per year, which yields losses above 5 M€/year per company. To avoid these huge costs, network administrators require network visibility: the ability to understand what happens in a network. Thus, companies are investing in visibility tools; the market of Network Performance Monitoring (NPM) is currently estimated at $2.4Bn, growing at >11% yearly. However, enterprises today are still not investing as much as they should in network visibility, because of (1) deployment complexity, which requires expert technicians and planned interventions, and (2) high upfront costs of both hardware and software-based solutions. A revolution in the networking world called SDN is currently undergoing. This new technology allows software components to alter the network, which becomes almost “programmable”. This opens a window of opportunity to create a SDN visibility product that removes both barriers: it can be deployed with one click, offered cheaply from the cloud at scale, and billed on a subscription basis. The market of SDN is currently $3.5Bn and will grow 10x until 2018. We believe that by combining SDN and network visibility we can at least double the market of our segment, increasing it by $2.4Bn. The objective of this project is to refine our current Business Plan and reduce the uncertainties in the project. By reducing risk, we will consolidate it and open it to further investment. In particular, we will seek an early adopter and refine the value proposition of our first version of the product. We are a company that commercializes network visibility solutions; our product (unrelated to SDN) is currently in commercialization stage, with many large-scale deployments. We therefore have the technical and business expertise to build and commercialize a novel network visibility product.

Keywords: software defined networks,network visibility,network management,software as a service
Light-controlled bright and stable plexcitonic quantum emitters operating in both single-photon and entangled-photon-pair emission modes (QESPEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-12
End date: 2023-07-11
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: TERMINATED

The emerging field of quantum information offers significant opportunities in quantum key distribution, quantum simulation and computation, metrology, and imaging. However, these applications require the use of quantum emitters that can generate single photons and pairs of entangled photons on demand. Perovskite quantum dots (PQDs), which can produce a highly coherent single-photon emission, are very promising as quantum emitters with a high single-photon purity, indistinguishability, and brightness. A unique property of PQDs is that, in contrast to many other emitters, biexciton states can be effectively generated in PQD. Two-photon photoluminescence (PL) resulting from biexciton recombination is one of effective ways of generating entangled photon pairs. However, the use of the full potential of PQDs as quantum emitters is hindered by the limitations associated with the instability of the PL signal and the low biexciton PL quantum yield. Nanoscale plasmon–exciton interaction can significantly stabilize and improve the PL properties of PQDs due to the appearance of hybrid plasmon–exciton (plexciton) states serving as quantum emitters, thus overcoming the aforementioned limitations of PQDs. The main goal of the present QESPEM project is to design highly efficient plexcitonic quantum emitters operating as on-demand sources of pure single indistinguishable photons and pairs of entangled photons. To achieve this goal, the following objectives will be fulfilled: (1) to design quantum emitters based on the PQDs and plasmon nanostructures with implemented synergistic combination of plasmon-induces effects; (2) to develop new approaches and methods to control different regimes of plasmon–exciton interaction in the designed structures; (3) to optimize the conditions of light–matter coupling to achieve the highest values of the generation efficiency, single-photon purity, and indistinguishability for the single-photon mode and entanglement fidelity for the photon-pair mode.

Keywords: quantum emitter,light matter coupling,nanohybrid material,plasmon exciton,plasmon nanoparticle,quantum dot,perovskite nanoparticle,single photon emission,entangled photons,quantum tomography