Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rational design of scaffold architecture and functionalization to induce healing and tissue regeneration (DESIGN2HEAL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Products and Processes Engineering
Countries involved: Germany
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-03-01
End date: 2019-02-28
Duration (months): 60.0
Total project cost (EUR): 1994200.0
EU funding (EUR): 1994200.0
Participants: 1
Project status: CLOSED

When materials are implanted into the body they initiate an inflammatory response that is difficult to control. Consequently medical implants are tolerated by the body rather than fully integrated; the material is often sealed off from the body in a fibrotic capsule. Most recent research suggests that morphology is a decisive immunomodulatory trigger and may favor a healing-like reaction of the innate immune system, especially of macrophages. I have pioneered a single-step method to generate non-woven fibrous scaffolds with surface chemistry control that allows specific cell adhesion. Additionally, my laboratory recently established melt electrospinning writing (MEW) that allows automated scaffold production by solvent-free electrostatic drawing with precise morphology control through rational deposition of polymer filaments in micrometer resolution. Design2Heal is based on this world-wide unique combination of technologies and proposes to combine form (scaffold morphology) with function (surface chemistry) to generate biomaterials that are designed to heal and improve implant integration. Pioneering and ground breaking research within Design2Heal includes: • A single-step procedure to fabricate MEW scaffolds with controlled surface functionalities for specific bioactivation. • Unraveling the immunomodulatory potential of generic scaffold parameters (diameter, morphology) and surface functionalization (peptides, sugars, glycosaminoglycans) for rationally designed scaffolds in vitro with primary human innate immune cells. • Resolve the immunomodulatory effects of cellular cross-talk and interaction between human immune cells, mesenchymal stem cells and endothelial progenitor cells in defined geometric confinements. • In vivo proof-of-principle in the murine model In case of success, Design2Heal will be a ground breaking first step towards actively healing implants independently of the affected tissue, with tremendous impact on healthcare worldwide.
Bioenergy Sustaining the Future 2 (BESTF2)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Horizontal programme actions
Action type: Coordination and support actions
Partnership: BESTF2 (ERA-NET)
Countries involved: Germany,Sweden,Netherlands,Spain,Switzerland,Denmark,United Kingdom,United Kingdom
Call:  (FP7-ERANET-2013-RTD, 2013)
Start date: 2013-12-01
End date: 2019-05-31
Duration (months): 66.0
Total project cost (EUR): 14553269.0
EU funding (EUR): 3714216.0
Participants: 10
Project status: CLOSED

This ERA-NET_Plus Coordination and Support Action, BESTF, will bring together a number of national and transnational initiatives in the field of bioenergy. It follows on from the first BESTF call that launched in January 2013 and, like its predecessor, aims to kick-start large scale investment in close-to-market implementation of bioenergy thereby helping to achieve the key objectives of the European Industrial Bioenergy Initiative (EIBI) Implementation Plan. This project is aligned to the wider strategic European requirement to increase the security and sustainability of energy supply. The key objectives of this second BESTF initiative are: 1.To implement a single collaborative funding call that will support projects focused on the generation of bioenergy. 2.To maintain and enhance coherence and networking between national bioenergy programmes across the EU. 3.To further the demonstration of enhanced bioenergy technologies in order to help develop robust project plans for a range of demonstrator and flagship plants, that will help Europe to make progress towards achieving its 2016 and 2020 energy targets. 4.To disseminate knowledge gained from the programme and individual projects across the EU. The BESTF programme will support bioenergy demonstration projects that: •Address one or more of the seven EIBI bioenergy value chains detailed above. •Provide an innovative process or step within the value chain (see detail below). •Are at an appropriate stage of development (see detail on TRLs below), and will move into demonstration phase within the timeframe of the programme. •Are industry-led and will enable confidence to be confirmed in commercial scale application.

Keywords: bioenergy,bestf,demonstrator,eibi,value chains,eranet plus
Sketching Audio Technologies using Vocalizations and Gestures (SKAT-VG)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and Emerging Technologies
Action type: Collaborative project
Countries involved: Italy,France,Sweden,France
Call:  (FP7-ICT-2013-C, 2013)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 3168299.0
EU funding (EUR): 2435491.0
Participants: 4
Project status: CLOSED

Sketching is at the root of any design activity. In visual design, hand and pencil are still the primary tools used to produce a large variety of initial concepts in a very short time. However, in product and media design the sonic behavior of objects is also of primary importance, as sounds may afford seamless and aesthetically pleasing interactions. But how might one sketch the auditory aspects and sonic behavior of objects, in the early stages of the design process? Non-verbal sounds, more than speech, are naturally and spontaneously used in everyday life to describe and imitate sonic events, often accompanied by manual expressive gestures that complement, qualify, or emphasize them. The SkAT-VG project aims at enabling designers to use their voice and hands, directly, to sketch the auditory aspects of an object, thereby making it easier to exploit the functional and aesthetic possibilities of sound. The core of this framework is a system able to interpret users’ intentions trough gestures and vocalizations, to select appropriate sound synthesis modules, and to enable iterative refinement and sharing, as it is commonly done with drawn sketches in the early stages of the design process. To reach its goal, the SkAT-VG project is based on an original mixture of complementary expertise: voice production, gesture analysis, cognitive psychology, machine learning, interaction design, and audio application development. The project tasks include case studies of how people naturally use vocalizations and gestures to communicate sounds, evaluation of current practices of sound designers, basic studies of sound identification trough vocalizations and gestural production, gesture analysis and machine learning, and development of the sketching tools.

Keywords: voice,sound analysis and classification,gesture analysis,sound synthesis,sonic interaction design
Speed of Adaptation in Population Genetics and Evolutionary Computation (SAGE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and Emerging Technologies
Action type: Collaborative project
Countries involved: United Kingdom,Austria,Germany,United Kingdom,Germany
Call:  (FP7-ICT-2013-C, 2013)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 2041400.0
EU funding (EUR): 1578080.0
Participants: 5
Project status: CLOSED

Biological evolution has produced an extraordinary diversity of organisms, even the simplest of which is highly adapted, with multiple complex structures. Evolutionary computation has found that many innovative solutions to optimisation and design problems can be achieved by artificial evolution via random variation and selection. Despite the centrality of evolution to biology and the usefulness of evolutionary algorithms in optimisation, the dynamics of evolution are not well understood. Consequently, population genetics theory can only make quantitative predictions about short-term, simple biological evolution, and the design and parameter tuning of evolutionary algorithms is mostly done ad-hoc in a laborious and cost-intensive process. Both fields have studied the speed of adaptation independently, and with orthogonal approaches. Our project brings together an interdisciplinary consortium of ambitious researchers from the theory of evolutionary computation and theoretical population genetics to synergise these complementary approaches and to create the foundation of a unified quantitative theory describing the speed of adaptation in both biological and artificial evolution. The transformative impact of this unified theory will lie in enabling long-term predictions about the efficiency of evolution in settings that are highly relevant for both fields and related sciences. Our approach will reveal how this efficiency is fundamentally determined by evolutionary and environmental parameters. Tuning these parameters will allow researchers from biology and computation to increase the efficiency of evolutionary processes, revolutionising applications ranging from evolutionary algorithms to experimental evolution and synthetic biology.

Keywords: evolutionary computation,population genetics,heuristic optimisation,computational intelligence
smart Walk with Autonomous Localisation Knowhow (SMARTWALK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The capacity of surveying and analysing personal mobility in indoor and outdoor spaces is a critical driver of the innovation towad sustainable and responsible mobility which is a challenge for the 21st century. But there is no practical, affordable, reliable, accurate and ethical technological solution for mapping pedestrian traffic. The good functioning of existing solutions is strongly limited by the availability and density of dedicated telecommunication network. Not only are they mainly working outdoors but they often force the user to choose a particular device, to adopt a specific behaviour and to share private data. Consequently there is a need for innovative geolocalisation processes. The project smartWALK, for smart Walk with Autonomous Localisation Knowhow, aims at developing new localisation algorithms based on data recorded with units already available in daily life following an autonomous processing strategy. New systems and methods will be investigated for filtering data from a handheld smartphone and estimate pedestrian’s displacement irrespective of the surroundings. The research includes a smart processing of walking features with MEMS signals collected during naturalistic walk. Thanks to the design and production of a multi-sensors pedestrian navigation platform, a dead reckoning strategy will be followed for proposing adaptive step length estimation and walking direction computation with temporal and frequency analysis, quaternion based filtering and computational geometry. The quality of the research outcomes will be assessed with realistic data collections. The nature of the proposed research is a safeguard for possible misuse of geolocation information, which will drastically change the strategy for addressing large public mobility issues. It will provide innovative algorithms for processing handheld signals and initiate new research ideas. The scientific results will provide a leading role to Europe in the market of personal navigation.

Keywords: pedestrian navigation system,pedestrian mobility,indoor navigation,dead reckoning,inertial mems,geolocalisation,location based services,signal processing,walk
Leakage-Resilient Cryptography (LRC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cryptography aims at designing schemes that are resilient to adversarial behavior. Although notions of adversarial behavior have significantly evolved over the years, the vast majority of cryptographic schemes are still analyzed in rather traditional adversarial models which do not capture various forms of unintendedly leakage of information (usually referred to as ``side channels''). Typical examples include electromagnetic measurements, timing information, and many more. Over the years side-channel attacks exposed crucial vulnerabilities in a large number of schemes that are in fact considered secure in the traditional models. Extensive research has been devoted to protecting against side-channels attacks, where traditional countermeasures aim at making the physical world as similar as possible to the abstract models by preventing unintended leakage of information (e.g., building ``tamper-proof'' devices). This approach, however, is typically inefficient, and even impossible to realize in many cases. Quite recently, research in cryptography has put forward a complementing approach, arguing that side channels should be taken into consideration, as much as possible, already in the initial design of systems, and not only during their implementation. Specifically, extensive research has been devoted to designing systems that are robust to realistic modifications of the traditional models. Despite this recent progress, however, research in cryptography is still quite far from obtaining a sufficiently good understanding of side channels. The main objectives of this proposal are to study the drawbacks and limitations of the current models and systems that have been developed so far, and to propose new approaches and techniques for realizing better, more realistic, ones. Accomplishing these objectives would minimize the gap between theory and practice in combating side channels, and as a result, increase the deployment of newly-developed leakage-resilient systems.

Keywords: cryptography,foundations of computer science,security,side channel attacks
Genetic interaction networks in a self-renewing human tissue (TISSUECONTROLNETWORK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Both epigenetic factors and microRNAs have the potential to control transcript levels of large sets of genes through transcriptional and post-transcriptional mechanisms. Faithful stem cell function is crucial for tissue maintenance and repair throughout life and requires these machineries to establish specific and dynamic transcription programs. However, how miRNAs and chromatin-factors cooperate to achieve this is poorly characterized. I previously developed genetic screening and computational approaches to determine the contribution of functional interplay among 332 chromatin-factors to epidermal differentiation. Now, I will pioneer the concept of genetic interactions between coding (chromatin-factors) and non-coding RNAs (miRNAs) using primary human epidermal stem cells as a well-characterised and clinically relevant model system. My lab will: (1) silence all individual miRNAs expressed in these cells to measure their contribution to stem cell renewal and differentiation. Innovative Bayesian statistics will then be employed to predict which miRNAs and chromatin-factors function together in functional/genetic interactions. (2) We will investigate the mechanism underlying these interactions using genomic, proteomic and cell biological approaches with particular attention to direct cooperation of nuclear miRNAs and chromatin-modifiers in transcription regulation. Together, understanding which genes in the genome cooperate, and how they do so, will not only deepen our understanding of normal biology, it will also help rationalise targeted (combination) therapies for disease, a major goal in modern clinical medicine.

Keywords: epigenetics,mirna,chromatin,genetic interaction,epidermal stem cell,keratinocyte,transcription regulation,ago2,chip,proteomics,genomics.
Demography, Politics and Conflict: The Case of India (TOFTCIG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2018-06-08
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: TERMINATED

This proposal seeks support for research on demography and conflict dynamics that builds on the principal investigator’s current work and expertise. The core focus of the research is an historical and statistical examination of the interaction of demographic factors and their impact on political conflict and violence, with a particular focus on India. The main objectives are theoretical and empirical: to develop a framework for understanding how demographic dynamics influence political conflict and violence, and a data set of conflict episodes and demographic variables. It will use state-of-the-art statistical methods to study important questions related to demography and politics. This project brings together a number of disciplines, including political science, history, statistics, economics and demography. Three main factors relating to political violence will be analysed: differential population growth and youth bulges, and then how these are related to horizontal inequality. Although this project initially focuses on India, the implications will be broadened to include other areas of world, in particular Europe. Consider the case of former Yugoslavia in the 1970s and 1980s, a case I explored in my first book. This country underwent profound ethnic shifts particularly between ethnic Albanians and ethnic Serbs in the Kosovo as result of fertility rates and migration. Similar dynamics are at work more broadly in Europe as fertility rates continue to decline in a fair number of countries (in some there is a bit of recovery, e.g. France and Sweden), putting pressure on these countries in terms of labour forces and immigration. These are the same dynamics I be examining in India and expect to explore them more broadly across the states of Europe and beyond.

Keywords: demography,politics,conflict,violence,youth bulges,inequality,development,civil war
International Protection of Human Rights as a Constitutional Issue: Promises, Problems and Prospects (HUMCONST2013)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2016-06-30
Duration (months): 34.0
Total project cost (EUR): 70833.33
EU funding (EUR): 70833.33
Participants: 1
Project status: CLOSED

International law is distinguished from other branches of law by the fact that States as its principal subjects are not only the addressees of law, but also creators of legal rules and guarantors of their enforcement. The idea of international constitutionalism attempts to place some constraints on the power exercised by States. Human rights form today a core of any Western constitutional order. However, the role of international human rights within international constitutionalism is articulated only rudimentarily. The project aims at filling this gap by analyzing current discourses on international constitutionalism and human rights in literature and jurisprudence of the International Court of Justice through an interdisciplinary and critical lens. Theoretically sound, practice- and policy- oriented proposals as to the more adequate articulation of the relationship between human rights and international constitutionalism will be formulated. In order to fulfill the aims of the project methodological tool developed in history, philosophy and sociology will be used. In order to seek new avenues for a more adequate fulfillment of human rights’ promise of protection the project will seek inspiration in non-western (Islamic law) and extra-legal (ancient Greece) normative orders. Through funding of research the grant will support successful integration of a promising academic into European research community and her establishment as a leading specialist in the field of human rights. It will also promote establishment of a research team and widening of the international network of the researcher. The Grant will thus contribute to the growing excellence of European research community and establishment of lasting collaboration with extra-European academic institutions.

Keywords: human rights,international constitutionalism,islam,philosophy
Probing Fundamental Physics with the Large-Scale Structure of the Universe (FUNDPHYSICSANDLSS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Over the past decade, cosmology, the study of the origin and evolution of the Universe and structure within it, has evolved into a precision science. While we have learned much about the evolution and history of the Universe, many of the most pressing questions remain unanswered, such as: Why is the Universe accelerating ? What is dark matter ? Does General Relativity correctly describe the Universe as a whole ? How did the Universe begin, and what is the origin of structure in the Universe ? The overarching goal of the proposed research is to make progress on these fronts through studies of the large-scale structure of the Universe. In particular, the research will attempt to probe our theory of gravity, and unravel the nature and origin of the initial seed fluctuations out of which all structure in the Universe formed. Beyond these two science goals, the proposed research includes new ways of measuring weak gravitational lensing, which is the most promising tool to study the "dark" ingredients of the cosmos that do not interact with light (such as dark matter and neutrinos). These research goals will be pursued on all three fronts of numerical simulations, analytical modeling, and confrontation with data. With its significant investment in cosmology space missions such as Planck and Euclid, as well as ground-based surveys, Europe is poised to assume a leadership role in experimental and observational cosmology. The proposed research will make significant contributions towards maximizing the science output of these experiments and thus contribute to European scientific excellence.

Keywords: cosmology,large-scale structure,galaxy redshift surveys,general relativity,gravitational lensing,galaxy clusters,inflation,planck mission,euclid mission