Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A scientifically proven, safe, naturally derived drug for the effective treatment of liver damage - an innovative solution for a significant unmet medical need (SULIPRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat builds up in the liver causing inflammation and eventually lead to permanent scarring (cirrhosis), which can seriously impair the liver’s ability to functions. NAFLD can progress to non-alcoholic steatohepatitis (NASH), and then to liver failure resulting in death unless there is a liver transplant. The prevalence of NAFLD in Europe is estimated to be between 26 and 33% of the general population. Currently, there is no available therapeutic treatment for patients with NAFLD and NASH. Natural Shield have developed a specialised oral therapeutic, called SULIPRO, which is a combination of soy derived compounds, that has been proposed as a novel scientifically proven safe treatment for patients in the early stages of NAFLD and NASH. Current drugs produced for liver diseases have a large amount of side effects and high financial costs that may preclude their long-term use in patients with NAFLD or the early stages of NASH. SULIPRO has already undergone positive clinical trials in animal models and successful Phase I clinical trials in humans showing demonstrating no side effects and high efficacy. The company now requires funding for a small Phase II trial. Once commercialised SULIPRO will be made available to consumers at an affordable price, as an over the counter (OTC) drug, available in shops/pharmacies and on the web, using an online distributor, such as Amazon. Natural Shield maintains its own research program involved in developing in parallel OTC food supplements, physician-prescribed medical foods, and FDA-approved botanical drugs. The company expects to reach the market with its first products within 24 months and thus far has raised over 5 million EUR in private funds.

Keywords: liver disease,nash,nafld,natural drug,over the counter drug,clinical trial
Allostery in Drug Discovery (ALLODD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Spain,Italy,Germany,Germany,Hungary,Sweden,Belgium,Greece,France,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 3627680.76
EU funding (EUR): 3627680.76
Participants: 14
Project status: SIGNED

Most current drugs are designed to bind directly to the primary active sites (also known as orthosteric sites) of their biological targets. Allosteric modulators offer a powerful yet underexploited therapeutic approach. They can elicit a richer variety of biological responses and, since they target less conserved binding sites, higher selectivity and less adverse effects may be obtained (Changeux, Drug Disc Today 2013). This proposal aims to train a new generation of scientists in exploiting the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems. Our approach is based on a combination of experimental and simulation techniques, including fragment Screening with structural characterization (X-ray, NMR, H/D exchange), proteomics (MS/MS), ITC, DNA encoding libraries, Virtual Screening, Molecular Dynamics simulations-based methods, Synthetic Chemistry, and in vitro and cellular assays for the verification of results. It should also be noted that allosteric targeting need not be achieved solely through the design of synthetic small molecules but also can also be reached via conformationally specific allosteric antibodies, which represents an important field of future research. There are already clear examples of monoclonal antibodies that allosterically target ion channels (Lee et al., 2014b), GPCRs (Mukund et al., 2013), and RTKs (De Smet et al., 2014), as well as cytokine and integrin receptors (Rizk et al., 2015; Schwarz et al., 2006).

Keywords: allostery,allosteric inhibitors,structure based drug design
Advancing the European Long-Term Ecosystem, critical zone and socio-ecological Research Infrastructure towards ESFRI (Advance_eLTER)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Israel,Germany,Germany,Italy,Germany,Bulgaria,Finland,Greece,Romania,Slovakia,Sweden,Switzerland,Norway,Serbia,Belgium,Hungary,Poland,Slovenia,Latvia,France,Czechia,Netherlands,Denmark,United Kingdom,Portugal
Call: Preparatory Phase and support to early phase of ESFRI projects (H2020-INFRADEV-2016-2, 2016)
Start date: 2017-01-01
End date: 2017-12-31
Duration (months): 12.0
Total project cost (EUR): 899820.01
EU funding (EUR): 899820.0
Participants: 29
Project status: CLOSED

Advance_eLTER marks a crucial step in building the distributed European Research Infrastructure of Long-Term Ecosystem Research sites and socio-ecological research platforms (eLTER RI) to provide highest quality data and services complementary to the European and global environmental RIs. The project will conduct important conceptual work and preparatory steps towards enabling European-scale investigation of the “Critical Zone”, major ecosystems and socio-ecological systems, targeted at supporting knowledge-based decision making at various levels concerning ecosystem services and biodiversity. The review of the eLTER ESFRI proposal submitted by Germany in March 2015 noted the HIGH to VERY HIGH scientific value and necessity of the eLTER RI and was designated as an ‘Emerging’ ESFRI RI. The objectives of Advance_eLTER are firmly anchored in the strategic long-term goals of the eLTER RI, but strictly focus on the challenges identified by the ESFRI review: ● Detailed design study (WP1), including an in-depth analysis of the scientific questions driving the eLTER RI physical site network design and instrumentation; ● Prioritization of eLTER services for key user groups (WP2), and a plan for eLTER RI services at all service provider levels (central, cross-site, individual site); ● Cost analysis and Business plan, for the future eLTER RI operation (WP3); ● Organisational framework of eLTER RI (WP4), comprising the development of a robust governance scheme, enabling shareholder negotiations and identifying the most suitable legal framework; ● Consulting, communication and team-building (WP5), advancing the national eLTER ESFRI processes, specifying the role of eLTER in the environmental RI landscape and developing staff capacity for the eLTER ESFRI process. Advance_eLTER will closely cooperate with all LTER related processes and projects and will result in a 2017 eLTER ESFRI proposal.

Keywords: long term ecosystem research,lter,critical zone,socio ecological research,ltser,services,environmental research infrastructure,in situ,research site,design study,business plan
Smart and Networking UnderWAter Robots in Cooperation Meshes (SWARMs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Italy,Germany,Spain,Italy,Spain,Spain,Germany,Spain,Norway,Türkiye,Sweden,Romania,Türkiye,Sweden,France,France,France,Netherlands,Netherlands,Portugal,Portugal
Call: ECSEL Key Applications and Essential Technologies (RIA) (ECSEL-2014-1, 2014)
Start date: 2015-07-01
End date: 2018-07-31
Duration (months): 37.0
Total project cost (EUR): 17168626.68
EU funding (EUR): 6389046.38
Participants: 32
Project status: CLOSED

Nowadays, the major part of offshore operations is done by divers in dangerous missions. Since their number is limited, the dependency on their work represents a real threat to the offshore industry. The extended use of unmanned underwater vehicles (AUVs/ROVs) could solve this problem but since they are usually tailor-made for a specific task and difficult to operate their deployment is very expensive. The overall goal of the SWARMs project is to expand the use of AUVs/ROVs and facilitate the creation, planning and execution of maritime and offshore operations. This will reduce the operational cost and increase the safety of tasks assigned to divers. The SWARMs project aims to make AUVs/ROVs accessible to more users by: • Enabling AUVs/ROVs to work in a cooperative mesh thus opening up new applications and ensuring re-usability as no specialized vehicles are needed but heterogeneous standard vehicles can combine their capabilities, • Increasing the autonomy of AUVs and improving the usability of ROVs The approach is to design and develop an integrated platform (a set of Software/Hardware components), incorporated into the current generation of underwater vehicles in order to improve autonomy, cooperation, robustness, cost-effectiveness, and reliability of the offshore operations. SWARMs’ achievements will be demonstrated in two field tests in different scenarios: • Inspection, maintenance and repair of offshore infrastructure • Pollution monitoring • Offshore construction operations SWARMs is an industry-led project: big technology companies will collaborate with SMEs specialized in the subsea, robotics and communication sectors and universities and research institutions to ensure that the newest innovations in subsea robotics will arrive fast to market. As voice of the customer, two end-users are also part of the consortium.

Keywords: maritime and offshore operations,autonomy and cooperation,autonomous underwater vehicles,remotely operated vehicles
Deciphering the cellular origin and evolution of malignant rhabdoid tumors (RhabdoEvo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Introduction How tumors adapt to changing environmental conditions and treatment is a major unsolved problem frustrating effective therapy. Rhabdoid tumors are highly aggressive pediatric tumors with a low survival rate. They occur in multiple tissues, including brain and kidney, and likely originate as a consequence of aberrant differentiation during development. Understanding the origin of rhabdoid tumors and the relationship with normal development is crucial for investigating new treatment options. The almost certain appearance of therapy resistance, low mutation burden, and recent epigenetic profiling suggest the existence of epigenetic heterogeneity within rhabdoid tumors. We hypothesize that epigenetic heterogeneity within rhabdoid tumors underlies their aggressive behavior. Goal I previously exploited organoid models and CRISPR technology to study colorectal cancer progression. My lab now developed a protocol to, for the first time, efficiently grow rhabdoid tumor organoids from patient tissue. We are in the unique position to identify the cellular origin of rhabdoid tumors and the key molecular mechanisms driving disease progression and therapy resistance. Approach We will I) apply single-cell epigenomic and transcriptomic analyses on tumor tissue for in-depth characterization of the cellular identity and heterogeneity within rhabdoid tumors II) combine our unique rhabdoid tumor organoids with genetic lineage tracing technology to reveal clonal dynamics in rhabdoid tumor progression and therapy resistance III) perform retrospective lineage tracing using somatic mutations to track down the cell-of-origin of rhabdoid tumors. Innovation Our integrative use of state-of-the-art technologies on unique patient-derived tissue and tumor organoids will provide comprehensive insights into the origin, heterogeneity and progression of rhabdoid tumors. This will also establish novel approaches for other cancer research as well as new concepts for improving therapy.

Keywords: intratumor heterogeneity,epigenetics,tumor origin,progression and therapy resistance,lineage tracing
Feasibility demonstration of 3D printing for a new efficient production method of mm-wave waveGUIDE antenna (3DGUIDE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain,Switzerland
Call: New Efficient production methods for 94 GHz (W-band) waveguide antennas (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 594950.0
EU funding (EUR): 530975.0
Participants: 3
Project status: SIGNED

Flight delays are costing billions of Euros yearly to the air transportation industry yearly. A large part of delays being linked to low visibility, Enhanced Flight Vision Systems are slowly coming to civil aircrafts and will eventually support pilots to land in any visibility condition. The Systems ITD of Clean Sky 2 aims to accelerate the development of new functions in cockpit systems for flight optimization in all conditions, increased crew awareness and efficiency. These new solution must however remain competitive in an industry under increasing cost pressure. To address these challenges, the 3DGUIDE project intends to demonstrate an affordable production method for high precision mm-wave waveguide antennas with Additive manufacturing (AM). AM is a promising candidate to produce antennas with complex 3D shapes, reduce assembly steps and decrease overall production costs. The selected process, Laser Powder bed fusion (L-PBF), a metal AM technology, is optimized by CSEM for high printing resolutions and will be benchmarked against traditional manufacturing processes through the manufacturing, testing and performances comparison of printed mm-wave slotted antenna array elements (e.g. WG, single slotted WG array). An inductive iris waveguide bandpass filter operating at 94 GHz is suggested as 3D printed phase shifter and dummy MEMS will be integrated into the phase shifter element structure for the project. Furthermore, a later integration of MEMS biasing lines printed in the WG structure will be tested. The project will target a TRL4. To reach these objectives, 3DGUIDE brings together an interdisciplinary team of experts including world-class researchers on radiofrequency and antennas (UPM), an industry expert in development and deployment of high frequency antennas in challenging environments (TTI), and finally an industry oriented research and technology organization well versed in leading and managing interdisciplinary international projects (CSEM).

Keywords: waveguide w band antenna radar 3d printing additive manufacturing efvs
Control of Bacterial Multidrug Tolerance and Stress Response by Alarmone Synthetase SpoT (STRINGENCY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1494042.0
EU funding (EUR): 1494042.0
Participants: 1
Project status: CLOSED

Difficult-to-treat chronic and recurrent bacterial infections are often caused by bacteria that are sensitive to commonly used antibiotics. The reasons for this recalcitrance are frequently unknown. However, when grown in the laboratory, all bacteria, including major pathogens form persister cells that are multidrug tolerant, a phenomenon thought to be a major factor underlying recalcitrant infections. We observed that the general bacterial stress response, known as “the stringent response”, plays a key role in persister cell maintenance. Indeed, stochastic variation of the stringent response regulator ppGpp triggers persister cell formation. However, the molecular mechanisms by which environmental cues activate the stringent response are still largely unknown and represent one of the most fundamental, unsolved problems in prokaryotic molecular biology. Importantly the stringent response is also required for virulence of almost all bacterial pathogens, strongly arguing that novel insights into ppGpp biology will lead to novel methods to combat infections. We recently observed that the ppGpp synthetase II activity encoded by SpoT is responsible for persister cell formation in Escherichia. coli. Therefore, I propose a research program that builds on the pivotal role of SpoT in bacterial persistence, with the goal of dissecting the molecular mechanisms by which environmental stimuli trigger SpoT-dependent ppGpp synthesis. This project has three main objectives: (i) To unravel how spoT expression is regulated (ii) To reveal how ppGpp synthetase II activity is mechanistically controlled and (iii) To decipher the physiological role of SpoT in persister cell decision-making. The program is ambitious and will provide a significant step forward for the persistence field and offer novel, fundamental insights into ppGpp biology. Moreover, it may represent an invaluable resource to improve biotechnological processes and how bacterial infections are treated.

Keywords: p ppgpp,stringent response,spot,bacterial persistence,bacterial virulence,multidrug tolerance,bacterial stress response
Development and experimental validation of computational models for cavitating flows, surface erosion damage and material loss (CaFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Austria,Singapore,Switzerland,Sweden,France,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3939999.12
EU funding (EUR): 3939999.12
Participants: 14
Project status: CLOSED

Cavitation, described as the formation of vapour/gas bubbles of a flowing liquid in a region where the pressure of the liquid falls below its vapour pressure, often leads to vibration and damage of mechanical components, for example, bearings, fuel injectors, valves, propellers and rudders, impellers, pumps and hydro turbines. Cavitation erosion when experienced, normally leads to significant additional repair and maintenance costs or component replacement. Even if erosion problems can be avoided by design or operation, most often the performance of the systems is sub-optimal because countermeasures by design are needed to prevent cavitation problems. Despite the long-lasting problems associated with cavitation, computational models that could simulate cavitation and identify locations of erosion are still not thoroughly developed. The proposed interdisciplinary training and research programme aims to provide new experimental data and an open-source simulation tool for hydrodynamic cavitation and induced erosion. Insight into the detailed bubble collapse mechanism leading to surface erosion will be realised through DNS simulations, which are now feasible by the significant progress in fluid flow computational methods and parallel simulations. Information from such models will be implemented as sub-grid scale models of URANS and LES approaches, typically employed for cavitation simulation at engineering scales. Model validation will be performed against new advanced X-ray, laser diagnostics and high speed imaging measurements to be performed as part of this project. Application of the developed models to cases of industrial interest includes fuel injectors, marine propellers, hydro-turbines, pumps and mechanical heart valves. From this understanding the development of methodologies for design of cavitation-free or remedial measures and operation of devices suffering from cavitation erosion can then be established for the benefit of the relevant communities.

Keywords: cavitation erosion simulation dns,urans,bem experiments x ray,spiv,imaging,pressures fuel injectors tubrines propellers pumps mechanical heart valves