Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IMPLEMENTING INNOVATIVE METHODS FOR SAFETY AND SUSTAINABILITY ASSESSMENTS OF CHEMICALS AND MATERIALS PARTICULARLY AT NANO LEVEL IN THE EUROPEAN UNION (CheMatSustain)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Germany,Poland,Netherlands,Denmark,Italy,Spain,United Kingdom,Sweden
Call: Innovative methods for safety and sustainability assessments of chemicals and materials (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4924128.75
EU funding (EUR): 4924128.5
Participants: 11
Project status: SIGNED

The Chemicals Strategy for Sustainability (CSS) has been adopted, which aims to tackle the challenge of producing and using chemicals to address societal needs while respecting the planetary boundaries and safeguarding people and ecosystems, by dealing with pollution from all sources (EC, 2019 or COM(2019)640final, COM(2020)667 final, JRC report). This CSS challenge gets operationalised through the development/implementation of two key R&I actions: 1) the Strategic Research and Innovation Plan (SRIP), and 2) the Safe and Sustainable by Design (SSbD) framework. Consistent with the aims of the Call HORIZON-CL4-2023-RESILIENCE-01-21 and bearing in the mind the pressing need to develop new methods or improve current ones, to support the improvement of safety and sustainability assessments of chemicals, the project “IMPLEMENTING INNOVATIVE METHODS FOR SAFETY AND SUSTAINABILITY ASSESSMENTS OF CHEMICALS AND MATERIALS PARTICULARLY AT NANO LEVEL IN THE EUROPEAN UNION (CheMatSustain)” will not only study the quantum effects from a fundamental point-of-view (by DFT means) but also by identifying and measuring them through experimental techniques (high-resolution analysis, XPS and UPS), and determining the specific molecular recognition through their interaction with the environment, which is a quantum mechanical effect (in-vitro, microfluidic in-vitro, and in-vivo models and proteomics and transcriptomics and methods). The obtained information on these descriptors will then be integrated for the development of novel in silico models for prediction (eco)toxicity properties of advanced materials. Finally, in-silico model prediction results will be combined to develop a new methodology for the complementary use of Risk Assessment and LCA to improve criteria for the SSbD implementation framework. The work has been divided in eight work packages and the duration of the project is 48 months.

Keywords: chemicals nanomaterials sustainability safety assessment in silico
Efficient Stable Multilevel Ferroelectric Tunnel Junctions Enabled by Layered 2D van der Waals Heterostructures (ESTRELLA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Through ESTRELLA I aim to develop energy efficient (i.e. field-driven), stable (retention time > 10 years), multilevel (16 state/4-bit) two-terminal devices based on 2D ferroelectric CuInP2S6 (CIPS). The project will provide a comprehensive investigation of CIPS material properties both as an exfoliated film and when integrated in ferroelectric tunnel junction (FTJ) devices through multilayer vdW epitaxy. The final devices aim to exploit the atomically sharp interfaces of vdW heterostructures, small domain wall energy and slow but stable switching of CIPS in order to produce a ferroelectric memory suitable for neuromorphic applications. Furthermore, I will investigate the impact of different electrodes on tunnelling electroresistance (TER) and switching voltages in order to design an optimal CIPS-based FTJ. This draws together my experience in the fields of ferroelectric devices and materials characterisation with that of the supervisor (Prof. Luis Hueso, CIC nanoGUNE), who is an expert on 2D materials and van der Waals (vdW) heterointegration. ESTRELLA will target areas of materials science - heterointegration techniques, 2D film characterisation; physics - understanding of domain dynamics and 2D material interfacial interactions; and electrical engineering - targeting FTJ devices as building blocks for neuromorphic computing. Parallel to my scientific work, with ESTRELLA I will develop skills as an independent researcher through publication and dissemination of my work, supervision, collaboration and project organisation.

Keywords: ferroelectrics,2d materials,van der waals heterostructures,neuromorphic,nanodevices
Scaling Enzymatic Recycling of blended PA6 Textile Waste (BIOPA6)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Epoch Biodesign is pioneering a breakthrough solution to the global challenge of plastic and textile waste through its proprietary enzymatic recycling platform. Our project focuses on the development and scale-up of an advanced process for the circular recycling of polyamide 6 (PA6), which represents over 50 % of the global polyamide market and is widely used in textiles, carpets, and packaging. Leveraging state-of-the-art enzyme engineering, artificial intelligence, and custom reaction conditions, our platform efficiently depolymerises even complex, contaminated PA6 waste streams at ambient temperature and pressure, reducing CO2 emissions by up to 80 % compared to conventional methods. This project will deliver the first dedicated enzymatic PA6 recycling line, producing high-purity monomers for in-house repolymerisation into virgin-quality, textile-grade rPA6. Our approach enables true textile-to-textile circularity, unlocks new value from previously unrecyclable waste, and positions Europe as a global leader in sustainable polyamide recycling. With EIC Accelerator support, Epoch will accelerate technical validation, de-risk scale-up, and demonstrate commercial viability, paving the way for a first-of-a-kind 10 000 t/year facility by 2030 and global expansion through strategic partnerships and licensing.

Keywords: depolymerisation,enzymatic recycling,polyamide,nylon
Hunting sub-GeV Dark Sectors (DarkSHunt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2470366.0
EU funding (EUR): 2470366.0
Participants: 1
Project status: SIGNED

There is incontrovertible evidence that the Standard Model is not the ultimate theory of particles and interactions: it cannot explain neutrino masses, dark matter, our own existence (i.e. the Universe baryon asymmetry). A New Standard Theory must exist. The key question is: what is the new physics scale? In the past decades, a formidable effort took place to explore the TeV scale, culminating in the LHC experiments, but no evidence of new physics has been found. A change of paradigm may be required. New physics at low masses, the so-called dark sectors, offers a viable alternative. Their theoretical study and experimental searches are blooming. The next 5 years offer a unique window of opportunity. New experiments will be taking data opening the possibility to search for dark sectors with unprecedented sensitivity and novel strategies: from the SBN programme, to ProtoDUNE, NA64, KM3Net, complemented by beam-dump, collider, sub-GeV dark matter, high energy neutrinos and gravitational wave searches. DarkSHunt ultimate aim is to exploit this opportunity to uncover hints (or evidence) of Dark Sectors, collaborating directly with leading experimentalists to perform dedicated analysis. It will focus on the most promising experimental strategies to search for heavy neutral leptons, dark photons, sub-GeV dark matter. It will adopt a phenomenological approach, necessary to combine information from diverse experiments, and will complement it with theoretical and astroparticle/cosmological considerations. It will focus specifically on rich (i.e. non-minimal) dark sectors at the GeV scale. Thanks to their multiple particles and interactions, they have strong theoretical motivation, can explain the 2023 discovery of nanoHertz gravitational waves and have nearly-unexplored phenomenology. If DarkSHunt achieves its ultimate goal, it would have a groundbreaking impact on our understanding of fundamental particles and interactions, paving the way to new research directions.

Keywords: dark or hidden sectors,neutrinos,neutrino and dark sector phenomenology,feebly interacting particles
Social Inequalities in the Risk and Aftermath of Miscarriage (SOC-MISC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: France,Finland,United Kingdom
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1256107.5
EU funding (EUR): 1256107.5
Participants: 4
Project status: SIGNED

One in four women experience a miscarriage. Loss of pregnancy may affect fertility intentions and lead to adverse mental and physical health. Yet, we know little about how social inequalities affect the risk of miscarriage; how miscarriages may exacerbate existing social inequalities in population health; or how context shapes these experiences. One reason for this is poor quality of data, as miscarriages are often either underreported in surveys or only included in health registers if they require hospital care. Moreover, to date, sexual and reproductive health has often been ignored in life course epidemiology. This proposal goes beyond the state-of-the-art by being the first comprehensive study of the patterns of social inequality in miscarriage and its outcomes. It reaches this goal by assessing the patterns of miscarriage underreporting in surveys before obtaining its estimates. It will make ground-breaking contributions by: 1) Analysing underreporting patterns of miscarriage and using this in further analyses to obtain more reliable results than before. 2) Showing how individual and family-level social inequalities affect miscarriage risk over the life course. 3) Establishing how mental and physical health consequences of miscarriage depend on one’s social background and may widen social inequalities in health. 4) Uncovering the role of national and sub-national context in social inequalities in miscarriage. Unlike many previous studies based on small and outdated samples, I use longitudinal population registers and large representative surveys in Finland, France and the UK that are exceptionally rich in miscarriage, socioeconomic, other reproductive and health data, and can be triangulated to obtain more reliable results. The project will lead to a significantly better understanding of a common reproductive experience affecting mental and physical wellbeing, and can help policy makers improve reproductive and population health.

Keywords: miscarriage,sexual and reproductive health,social demography,sociology,social epidemiology,pregnancy,social inequalities in health
Isotope iMAGing for Ice Core Science (IMAGICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

The "Isotope iMAGing for Ice Core Science" (IMAGICS) project aims at pushing the resolution of water stable isotopes analysis of ice cores down to the millimiter-scale for detecting fast and abrupt climate signals imprinted in the 3D isotopic features of the ice. Recent studies on shallow cores and on snowfalls showed large variability of the snow isotopic composition during buildup of the snowpack. Such spatial and temporal features are then archived in the cross sectional and longitudinal components of the ice core. However, there are no published attempt aimed at investigating whether and how different climate conditions imprint both the horizontal and vertical isotopic composition variability of ice cores. Indeed, such high-resolution features can't be detected with current state-of-the-art techniques like Continuous Flow Analsys coupled to Cavity Ring-Down Spectroscopy (CRDS), because the analysis can be performed only on the longitudinal component of the core with limited resolution. Instead, an innovative combination of CRDS and the micro-destructive technique Laser Ablation (LA) can be used to probe the isotopic composition of the ice both vertically and horizontally. An important feature given by LA is that almost the entire sample can be retained after analysis, allowing preservation of the ice for future analysis. IMAGICS will bridge CRDS and LA technologies to develop an innovative analytical framework to study ice cores. After an initial phase focused on coupling optimisation between the instruments, the project will be focused on detecting spatial features of the isotopic composition of real ice core samples from different historical periods. The results of IMAGICS will not only impact on the glaciology and paleoclimate research communities, by providing a better tool to identify past abrupt climate changes, but will also open the possibility to use different CRDS gas analysers with LA systems on different matrixes, such as speleothems and meteorites.

Keywords: ice core imaging,water stable isotopes,laser ablation,cavity ring down spectroscopy
Compositional Higher-Order Reasoning about Distributed Systems (CHORDS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2470023.0
EU funding (EUR): 2470023.0
Participants: 1
Project status: SIGNED

Software systems are critical for the infrastructure of modern society and software errors and security breaches pose enormous costs and risks. The traditional method of testing software systems is famously inadequate for guaranteeing the absence of errors and security breaches since not all execution paths are covered by testing. This is espcially true for concurrent and distributed systems, where there are simply too many execution paths to test, and it has motivated research in formal methods for program verification that can offer mathematical proofs that all system behaviors meet some desirable property. To formally analyze and reason about software systems it is important to consider models at many different levels of abstraction. Since many real software errors and security breaches stem from subtle problems in implementations of software systems, we focus on detailed, so-called semantic, models of program execution. While there has been much research on abstract models for reasoning about distributed systems, there has been very little work on compositional verification of implementations of distributed systems. Compositional verification enables specification and verification of individual software modules and their composition, and is key to achieving scalable methods that apply to large programs, but the devel- opment of logics and methods for compositional reasoning is hard. For concurrent, non-distributed, programs there has been tremendous progress in the last decade on program logics for compositional verification, in particular through the development of so-called higher- order concurrent separation logics. Leveraging this progress, CHORDS will research and develop new theories, program logics, and methods for mathematically rigorous compositional reasoning about implementations of distributed systems and thus lay the foundation for tools that will help programmers make more correct and secure distributed systems.

Keywords: program verification,separation logic,distributed systems
The Bootstrap Program for Quantum Field Theory (QFTinAdS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1930051.25
EU funding (EUR): 1930051.0
Participants: 1
Project status: SIGNED

The importance of quantum field theory (QFT) in modern theoretical physics is hard to overstate. Nevertheless a proper mathematical framework to describe field theories is still lacking. This is felt most concretely in the world of scattering amplitudes, whose general properties are difficult to define from existing axioms. This hampers our ability to make progress in understanding strongly coupled field theories. In contrast, for conformal field theories (CFTs) there has been remarkable progress in recent years. The key ingredient here is the operator product expansion, which both significantly constrains correlation functions and whose associativity conditions can be analyzed numerically. These techniques are however only suitable for theories with a conformal symmetry, which normally only emerges at the endpoints of finely tuned RG flows. To advance the non-perturbative understanding of strongly coupled non-conformal QFTs new methods are needed. Among other things it is imperative to grasp the non-perturbative structure of scattering amplitudes. I propose to follow two interlinked paths based on recent results. The first approach concerns the flat-space limit of a QFT in a fixed hyperbolic background known as Anti de-Sitter (AdS) space. The second approach can be called the numerical S-matrix bootstrap. Both approaches hold great promise, but by pursuing them jointly I will be able to optimally leverage insights from one approach into the other.

Keywords: quantum field theory
A novel phase-1/2a clinical trial for a next-generation oncolytic therapy targeting treatment of platinum-resistant high-grade serous ovarian cancer (OCTOPOD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 30.0
Total project cost (EUR): 2499951.0
EU funding (EUR): 2499951.0
Participants: 1
Project status: SIGNED

Annually 87,894 EU citizens are diagnosed with ovarian cancer (OC). >75% are diagnosed at an advanced stage with poor long-term outcomes (<25% 5-year survival). Standard-of-care first-line treatments combine cytoreductive surgery, platinum-based chemotherapies, and paclitaxel. Although initially effective, most patients relapse (>70% within 3-years) and become resistant to treatment. The are no effective treatments for platinum-resistant OC and patients have a life expectancy of <12-months. Emerging immunotherapies have demonstrated disappointing results for OC. This is believed to result from the heterogeneous and immune suppressed nature of the tumour microenvironment, and high volume of cancer-associated fibroblasts (CAFs), that create physical barriers to therapeutic penetration and promote tumour survival mechanisms. Oncolytic viruses (OVs) are an emerging immunotherapy class that selectively infect cancer cells and induce immunogenic cell death, leading to tumour reduction, modulation of the tumour microenvironment (lifting immune suppression), and stimulation of adaptive immune responses. Importantly, OVs demonstrate phenotypic selectivity, overcoming challenges of heterogeneity. However, existing OVs are developed from seroprevelant wild-type viruses (requiring intratumoural delivery) that are not evolved for oncolytic use (suboptimal efficacy and systemic activity). THEO-260 is a next-generation OV-therapeutic demonstrating: • world-first dual efficacy, targeting both CAF- and cancer- cells, • high tumour selectivity (low toxicity), • strong TME modulation (immune cell infiltration) and adaptive immune responses, • low seroprevalence (intravenous delivery via standard-of-care practices), and • high systemic activity (treatment of metastatic tumours/ascites). THEO-260 is anticipated to deliver a step-advancement in PROC treatment, extending patient survival (>36-months) and quality-of-life, and doubling 5-year survival rates for advanced stage disease.

Keywords: ovarian cancer oncolytic virus therapy tumour microenvironment cancer associated fibroblast immune suppression heterogeneity bioselection diversification transgene arming