Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DEVELOPMENT OF ANTIMICROBIAL, ANTIVIRAL, AND ANTIFUNGAL NANOCOATINGS FOR EVERYDAY SURFACES (MIRIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Poland,Sweden,Finland,Czechia,France,Germany
Call: Antimicrobial, Antiviral, and Antifungal Nanocoatings (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 5845858.5
EU funding (EUR): 5845857.0
Participants: 15
Project status: SIGNED

Since the end of 2019, the spread of COVID has deeply changed our lifestyle, resulting in historical events and decisions, such as the EU block of non-essential travel among countries (COMM (2020) 499), affecting the whole EU society economically and psychologically. However, as reported in the HERA target priorities, the persistence of the emergency status requires daily actions that tackle the spread of COVID. In this economical, societal and clinical context, the project MIRIA aims to develop wide-range-antimicrobial nanocoatings to be used in hospitals and other environments where cross-contamination and contagion risk are significant issues. In the wake of the covid outbreak, there has been large concern about infection spread of pathogens (i.e., bacteria, fungi, virus, and specifically SARS-CoV-2) via high traffic surfaces (i.e., medical equipment). State of the art and commercial products coating solutions that both target a range of mixed pathogens and different surfaces (e.g., glass, metal, textile) are unfortunately scant. MIRIA solutions aim to fill this void, impacting on EU health, both directly (by creating public safe environments) and indirectly (by reducing COVID spreading and decreasing ill-related work absences and psychological pathologies). A reduction of the work absence of at least 5% with respect to the 2020 value (15M in EU) is expected. MIRIA main challenging ambition is to develop nanocoatings with a 99.99% effectiveness against a wide range of pathogens, especially SARS-CoV-2. This will be based on a four pieces puzzle: the knowledge in anti-microbial materials, nanopowders, nanocoating and pilot plant conduction. These nanocoatings will be brought to pilot scale (TRL6) and, within 3 years after the end of the project, they are foreseen to enter the market (TRL9). The exploitation of MIRIA outputs deeply involves SMEs and the dissemination plan will follow a spill-over strategy in order to involve public and private stakeholders.
Cognitive deficits resulting from selective vulnerability of septal inhibitory neurons: mitochondrial dysfunction as a driver? (VulnerableInhibition)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Septal GABAergic projection neurons are considered “pacemaker” cells as they enable the temporal organization of neuronal spike firing in hippocampal and entorhinal networks that support spatial- and object-coding. Accordingly, medial septum inactivation is associated with cognitive impairments, but the specific role of the septal-entorhinal GABAergic projections therein has remained unexplored. This is a pressing question, as we have evidence that septal GABAergic projections exhibit enhanced vulnerability. In mouse models with neurodegeneration, we found that septal GABAergic axons exhibit signs of degeneration when target cells in the entorhinal cortices are not yet impaired. Furthermore, we have evidence for mitochondrial pathology in the degenerating axons. These results prompt the following questions: How does malfunction of septal GABAergic projections translate into dysfunction of downstream networks involved in episodic memory and spatial navigation? What are the mechanisms that render septal GABAergic projections prone to vulnerability? Employing in vivo electrophysiology combined with optogenetics, behavioral studies, 2-photon imaging of axons and mitochondria in live mice and spatial transcriptomics, we will tackle the following issues: (A) assess how impaired septal GABAergic projections affect spatial- and object-coding in the medial and lateral entorhinal cortex (MEC and LEC), (B) assess the functional consequence thereof on spatial and associative memory in the LEC (C) gauge putative cellular mechanisms, with focus on mitochondria, that render septal long-range GABAergic projections vulnerable and (D) identify genes/gene networks whose expression is involved in degeneration of septal GABAergic neuron axons. With these studies we will elucidate how septal neurons contribute to cognition, reveal common mechanisms for axonal degeneration, and ideally identify novel biomarkers and therapeutic targets for “mitochondropathies”.

Keywords: mithocondria dynamics,axon degeneration,spatial coding,object coding,path integration,spatial transcriptomics
Host-virus interactions in marine diatoms across environmental and ecophysiological gradients (InterDiVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1868196.0
EU funding (EUR): 1868196.0
Participants: 1
Project status: SIGNED

Diatoms shape the global carbon cycle, contributing ~20% of primary production on the planet and nearly half of the carbon sequestration in the ocean. Marine viruses transform ecological, evolutionary and biogeochemical processes, yet the impact of viral infection on diatoms remains a fundamental gap in our understanding of microbial dynamics in the ocean. The landmark discovery of diatom-infecting viruses, together with advances in high throughput sequencing and imaging technologies now enable the exploration of diatom host-virus interactions at unprecedented resolution. We know very little about when, where and how viruses impact diatom populations, despite the potential for viral infection to radically alter diatom ecology and diatom-mediated biogeochemistry. Proposed work seeks to elucidate how virus infection of diatoms manifests along environmental and ecophysiological gradients in the ocean. Our team will pursue three complementary aims: (1) Characterize the impacts of environmental stress on virus production and virus-mediated mortality in diatoms; (2) Determine the ecophysiological frameworks that drive diatom host-virus dynamics; (3) Capture and contextualize diverse host-virus interactions throughout a diatom bloom. Using a multi-tiered and interdisciplinary approach that draws upon molecular biology, biogeochemistry and biological oceanography, we will interrogate diatom host-virus interactions across environmental gradients in model systems and natural communities. Amidst the urgency to decipher how ocean processes respond to global climate change, InterDiVE will provide invaluable ecological, ecophysiological, and molecular insight into how environmental conditions regulate diatom host-virus interactions, advancing our understanding of the microscale dynamics that underpin primary production and biogeochemical cycling in the global ocean.

Keywords: biological oceanography,host virus interactions,marine microbes,environmental stress,phytoplankton,diatoms,primary production
Accelerating Differentiable Robot Dynamics Simulation for Advanced Control (ExTRAORDiNary)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Differentiable robot dynamics simulation is a crucial enabler of advanced robot control. It is at the heart of both model predictive control (MPC) and learning-based approaches (e.g. reinforcement learning [RL]), which are among the most successful and actively researched robot control algorithms. Increased usage of the computationally demanding MPC/RL controllers has led to a growing need for efficient dynamics simulators. However, existing simulators internally use inefficient high-complexity (worst-case cubic) constrained dynamics algorithms (CDA) and are often inefficiently implemented leading to a slowdown of several factors compared to a fast simulator like Pinocchio. Addressing these concerns, we will accelerate the differentiable simulation through three complementary strategies. We will 1) leverage low-complexity CDAs, 2) use Pinocchio's proven efficient software design patterns and explore further acceleration via code generation computations, and 3) derive efficient algorithms for differentiating through contact simulation. Furthermore, our simulator will solve the nonlinear complementarity problem of frictional contact without making physics-compromising relaxations like existing simulators and will be publicly available as part of the widely used open-source Pinocchio library. By adding key enhancements to Pinocchio, we will make it a viable alternative to the inefficient, but feature-rich software simulators. The visibility, impact and usability of our simulator will be enhanced by addressing some low-hanging fruits in MPC, RL and physics identification applications. This project’s contributions will not only pave the way towards fast whole-body controllers and faster and more sustainable RL training (important a time surge of RL research activity), but will also impact adjacent fields like bio-mechanics and computer graphics in the long term

Keywords: efficient algorithms,rigid body dynamics,contact dynamics,robot dynamics,model predictive control,reinforcement learning,open source software
Center of Excellence for Exascale CFD (CEEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Sweden,Greece,Spain,Germany,Denmark
Call: Centres of Excellence preparing applications in the Exascale era (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7812711.25
EU funding (EUR): 3906355.38
Participants: 8
Project status: SIGNED

For many centuries, scientific discovery relied on performing experiments and the subsequent deduction of new theoretical models. The advent of powerful computers, coupled with new and ever more efficient numerical algorithms, makes it possible to simulate complex systems with increasing realism, and to automatize even model discovery using artificial intelligence (AI) technologies. Computational Fluid DynFor many centuries, scientific discovery relied on performing experiments and the subsequent deduction of new theoretical models. The advent of powerful computers, coupled with new and ever more efficient numerical algorithms, makes it possible to simulate complex systems with increasing realism, and to automatize even model discovery using AI technologies. Computational Fluid Dynamics (CFD) is one of the most prominent areas that clearly requires, and even motivate exascale computing to be part of the engineering and academic workflows. Given the physical scaling and the availability of highly efficient simulation codes, CFD has the potential of reaching exascale performance, as one of the few application areas. This center will implement exascale ready workflows for addressing relevant challenges for future exascale systems, including those procured by EuroHPC. The significant improvement in energy efficiency will be facilitated through efficient exploitation of accelerated hardware architectures (GPUs) and novel adaptive mixed-precision calculations. Emphasis is furthermore given to new or improved algorithms that are needed to exploit upcoming exascale architectures. The efforts of the center are driven by a collection of five different lighthouse cases of physical and engineering interest, ranging from aeronautical to atmospheric flows, with the goal of reaching TRL 4 and even 5 for selected cases. All development is done in five European HPC codes which span the entire spectrum of CFD applications, including compressible, incompressible and multiphase flows.

Keywords: cfd,exascale,algorithms
Towards a sustainable wine industry: Application of blue economy concept (BluWine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,France,Germany,Portugal,Botswana,South Africa,Chile,Australia
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 701400.0
EU funding (EUR): 701400.0
Participants: 9
Project status: SIGNED

The BluWine project will encompass the entire wine production chain through a Blue Economy approach, where the vineyard, winemaking process, winery, and its residuals will be interactively linked and strengthened as part of a sustainable strategy. The wine industry is an important sector contributing to the economies of many countries, especially in Europe, which has a long history of wine production, as well as in emerging wine-producing regions in Africa, Asia, South America, and Oceania. From a global perspective, the collaboration of productive forces from different countries can be mutually beneficial. With a strong focus on environmental respect and sustainability, the BluWine project will be a collective effort to drive innovation in viticulture, winemaking, and winery operations, as well as in the management of its residuals. This will include improving grape resistance, managing wine ethanol content, recovering carbon dioxide, optimizing water usage, and recycling grape pomace, among other initiatives. The project will evaluate both the economic and environmental impacts, conducting a thorough analysis of barriers and socioeconomic drivers for successful implementation. The ultimate goal of the BluWine project is to ensure the control and maintenance of wine quality, which will be achieved by creating a new network dedicated to applying the Blue Economy in the wine industry. This will be supported through a strategic staff exchange program, bringing together both early-career and experienced researchers with expertise relevant to the BluWine project. Through this exchange, skills and knowledge will be shared across the Consortium. The project is organized into nine work packages, to be completed over four years, involving 13 ESRs (8 ESRs to be enrolled) and 50 ERs, for a total of 140 months of staff secondments. This will provide training in an international setting, further enhancing the skills and expertise of the participants.

Keywords: wine production chain,blue economy,chemical use,analytical methods,winemaking wastes,water management,carbon dioxide release,life cycle assessment
Exploratory Program Synthesis (EXPLOSYN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Our goal is to create Program Synthesis that can be used during Exploratory Programming to boost productivity and reliability when programmers write code. Program synthesis generates code for programmers so they can focus on the problem-solving aspects of their work. This often requires programmers to write a specification for the desired code, but this specification may not exist. Many aspects are initially undecided: implementation details, the division into subtasks, and at times even what the result should be. This leads programmers to use Exploratory Programming: refining their understanding of the code by writing the code. User studies we conducted to evaluate previous synthesis tools highlighted the chasm between what programmers know before writing code and the specifications program synthesis needs. We will develop Exploratory Program Synthesis: tools that can support the programmer even when their initial specification of the task is lacking. Exploratory Program Synthesis will hinge on finding non-disruptive ways for the programmer to use synthesis while still using specifications so that results retain a notion of correctness. This will require a better understanding of both exploratory programming and existing user-centric challenges in program synthesis, and will produce new synthesis interaction models backed by new synthesis algorithms. The conceptual leap is finding ways for programmers to interact with synthesis that are designed for the needs of both programmer and synthesizer by better understanding both, forming an interface between the two that is mutually beneficial. Exploratory Program Synthesis will revolutionize programming by letting the wealth of synthesis research be integrated into programmers' day-to-day work, allowing programmers to generate code that is attuned to their work trajectory. The algorithms and interaction models developed in this research will significantly improve programmers' ability to write correct code quickly.

Keywords: program synthesis,interactive synthesis,exploratory programming
Segregation of Opportunities: Pathways to Marginalization through Neighborhoods and Peers (SEGOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1499606.0
EU funding (EUR): 1499606.0
Participants: 1
Project status: SIGNED

Social and economic exclusion is a major challenge worldwide, attracting substantial research efforts across various disciplines. Yet, research has been largely unsuccessful in providing robust knowledge that can promote inclusion. One key reason is that marginalization is a multifaceted challenge that cannot be tackled within disciplinary boundaries. SEGOP will push the research frontier by integrating perspectives and methods from sociology, psychology, behavioral genetics, and economics. My main objective is to provide nuanced knowledge about how marginalization processes unfold through interactions between family background, individual characteristics, and neighborhood and peer characteristics. With SEGOP, I will lead an interdisciplinary team of researchers. We will leverage uniquely rich population-wide register data linked with large-scale survey data on nuanced developmental mechanisms and outcomes, as well as molecular genetic data. Together we will: 1. Investigate stability and persistence across different aspects of marginalization, and forecast which children and youth will experience persistent long-term marginalization. 2. Discover when, why, and for whom neighborhood and peer processes during childhood and youth lead to marginalization. 3. Uncover whether intergenerational transmission of disadvantage occurs through segregated opportunities. With surging inequality, growing socioeconomic achievement gaps, and increasing neighborhood segregation, there is an urgent need to understand pathways leading to marginalization. My interdisciplinary research profile, broad research background, and expertise in quantitative methods make me uniquely suited to lead this timely project. By integrating fragmented disciplinary perspectives, I have the groundbreaking opportunity to unravel mechanisms leading to marginalization. This knowledge will inform policy with the potential to reduce barriers to inclusion and give all children equal chances to succeed.

Keywords: neighborhood effects,peer effects,causal inference,quantitative methods,social stratification