Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Photo-electro Integrated Next-Generation energy technologies (PHOENIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Spain,Austria,Poland,France,Switzerland
Call: Next generation of renewable energy technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 2966261.26
EU funding (EUR): 2966261.25
Participants: 10
Project status: SIGNED

To combat global warming, achieving net-zero or net-negative CO2 emissions is imperative. The EU, aligning with the Paris Agreement, aims to reduce emissions by 40% and increase renewables share to 32% by 2030. Another challenge that the globe faces is the massive accumulation of PET plastic waste, prompting the EU to seek innovative recycling solutions. Solar-powered systems offer a clean, cost-effective alternative by converting CO2 into fuels while simultaneously recycling PET waste into high-value products. Moreover, integrating PET oxidation also aims to overcome the substantial overpotential loss associated with conventional reactions, making the process more efficient. The project PHOENIX seeks to facilitate the step-wise conversion of CO2 (initially from CO2 to CO, followed by converting CO into propanol) and simultaneously transform PET plastic waste into glycolic acid through an innovative strategy. The proposed concept stems from designing a multi-reactor CO2 reduction pathway that smoothly integrates photovoltaic-electrolyzer (PV-EC) and photoelectrochemical (PEC) technologies. To facilitate these processes, PHOENIX will develop and integrate an advanced tandem photovoltaic system that generates> 2 V, novel electrocatalysts that convert CO to n-PrOH and PET to glycolic acid and efficient photoelectrodes. Finally, the PHOENIX concept will also be validated to TRL 3-4 through a lab-scale demonstration, identifying and tackling the environmental impact through Life Cycle Assessment and evaluating the materials' recyclability. PHOENIX addresses two pressing global issues in a high-risk/high-return kind of approach, ultimately promoting a breakthrough in the renewable energy sector.

Keywords: solar fuels,co2 reduction,waste plastic recycling,catalysts,life cycle analysis
Ultrathin Two-Dimensional Polymer Heterostructure Membranes Enabling Unidirectional Ion Transport (2DPolyMembrane)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Netherlands
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 3
Project status: SIGNED

Current separation technology is crucial for many aspects of human life and accounts for ~15% of the world’s energy consumption. While the particle flow through separation columns is directional at the atomistic scale, undirected Brownian motion dominates in state-of-the-art membranes. 2D membranes have the potential to overcome this intrinsic deficiency and shift the paradigm of particle transport from disordered Brownian motion to unidirectional flow. We will develop unprecedented 2D polymer heterostructure membranes (2DHMs) combined with functionalized graphene. They offer ultimate thinness (leading to shortest diffusion lengths), precision pore geometry/size (resulting in high size-selectivity, even for hydrogen isotopes), and high functionality (fostering chemical/charge selectivity and ionic gating), making them ideal membrane materials to realize selective and unidirectional ion transport. We will combine our complementary expertise in theory and prediction, chemical design, and on-water/liquid surface synthesis, as well as in-situ ion transport investigations to develop robust 2DHMs. We will synthesize 2DHMs in the form of horizontal and vertical heterostructures, for which reliable structure-property correlations will be established. We will take advantage of lattice vibrations, nuclear quantum, and electrochemical effects, and consequently reformulate classical diffusion theory to consider these game changers. As a result, we will achieve innovative 2DHMs for selective proton and ion transport with high permeance, laying the foundations for the next-generation membrane technologies. 2DPolymembrane will unlock the unique opportunities of 2DHMs for innovative energy device integrations (proton/aqueous metal batteries, fuel cells, and reverse osmotic power generators), where the merits of ultrathin precision 2DHMs will result in the highest selectivity and highest particle flow, and thus a fundamental device performance beyond the state-of-art.

Keywords: interfacial synthesis two dimensional polymer heterostructures hydron sieving ion transport separation membranes
Mutational atlas of dengue virus non-structural protein 1 (NS1) in cell culture and mosquitos: mapping infection at single-cell resolution (MOSAIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-02
End date: 2028-02-01
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Dengue virus (DENV) is the most prevalent arbovirus worldwide and its ability to rapidly evolve and adapt complicates efforts to control its spread. A key factor in the replication cycle of DENV is the multifunctional non-structural protein 1 (NS1), which is involved in viral replication, transmission, and pathogenesis. Despite its importance, the evolutionary constraints and host-specific functions of NS1 remain poorly understood. To address this gap, I propose MOSAIC: a comprehensive approach to map the impact of NS1 variants on DENV infection. Using deep mutational scanning (DMS), I will generate diverse viral populations to assess the fitness effects of DENV NS1 variants in mosquito and human cell lines, uncovering host-specific selective pressures. These diverse populations will then be used for in vivo mosquito infection to generate a detailed atlas of NS1 variant distribution across mosquito cells and map the corresponding mosquito transcriptome at single-cell resolution. By combining my expertise in virus evolution with the leading work of the host lab on insect immunity, MOSAIC will uniquely integrate DMS and single-cell transcriptomics, establishing the foundation for novel ways to understand virus evolution at high resolution. MOSAIC will reveal insights into the evolutionary constraints of DENV NS1, identify transmission bottlenecks in distinct mosquito organs and cell types, and explore the interaction between DENV and mosquito immunity. This work will advance our understanding of flavivirus biology and host-virus interactions from a novel perspective, informing the development of new vector control strategies, vaccines, and therapeutics to combat DENV and other arboviral diseases in line with EU global health priorities. Finally, MOSAIC will provide me with multidisciplinary training in advanced genomics, vector biology and bioinformatics, strengthening my expertise in infectious disease research and preparing me to become an independent researcher.

Keywords: dengue virus,deep mutational scanning,single cell transcriptomics,flaviviruses,virus evolution,host virus interaction,insect immunity,mosquito infections
A molecular basis of kinetoplastids SL trans-splicing (TranSplice)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1765625.0
EU funding (EUR): 1765625.0
Participants: 1
Project status: SIGNED

Kinetoplastids are unicellular eukaryotic parasites responsible for severe human pathologies, such as sleeping sickness, Chagas disease and leishmaniasis. Kinetoplastids have diverged early during evolution and harbor many intriguing cellular and molecular peculiarities. Among these is their remarkably streamlined nuclear genome characterized by a high gene density and significantly divergent and specialized gene expression systems. A main example of such divergence is the polycistronic transcription of all their genes producing long messenger RNA precursors (pre-mRNAs) containing tens to hundreds of coding sequences. These pre-mRNAs are dissected into monocistronic mRNAs by SL trans-splicing, a process during which a spliced leader (SL) RNA is intermolecularly fused to the 5’end of all mRNAs by the trans-spliceosome. Although this machinery is essential for gene expression, the lack of structural information and the high divergence of its RNA and protein elements have hindered a mechanistic understanding of how kinetoplastids employ SL trans-splicing to generate their entire mRNA transcriptome. Here, we will use innovative approaches to provide the structural and mechanistic basis of SL trans-splicing in kinetoplastids by using cutting-edge structural biology techniques and state-of-the-art genetic and in silico tools. By combining genome editing, purification of endogenous trans-splicing machineries, high-resolution cryo-electron microscopy, AI-based interactome approaches, and novel in vivo assays, we will reveal the mechanism of SL snRNP biogenesis, the molecular basis for SL snRNP intermolecular recognition and activation by the trans-spliceosome, and the central mechanism of trans-splicing orchestrated by the highly divergent kinetoplastids trans-spliceosome. The outcome of this research will transform our understanding of RNA trans-splicing in eukaryotes and will pave the way for developing new drugs that specifically target this unique and essential pathway.

Keywords: trans spliceosome cryo em trans splicing ribonucleoprotein gene expression regulation kinetoplastids parasites
Optical imaging platform for high-throughput longitudinal studies of the eye in disease models (OPTIMEYEZ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Loss of vision is frequently related to disorders of the retina that may be either primary or secondary such as involvement in metabolic or neurologic disorders. Since the retina constitutes an easily accessible outpost of the brain, it emerged as top research target for non-invasive diagnostics of neurological diseases such as Alzheimer’s disease. Preclinical testing in rodents is an essential element in the process of exploring novel therapeutic compounds. The gold standard for such research and development read-out relies on histological confirmation, which, however, requires the animals to be sacrificed. In contrast, optical imaging methods enable rapid identification of pathologic tissue structures based on intrinsic contrast. In ERC Starting Grant OPTIMALZ, we have developed a novel multi-contrast optical imaging platform for longitudinal studies of the retina. Based on high-speed optical coherence tomography (OCT) technology, our prototype provides 3D images based on the light backscattered from the retina as well as polarization contrast for the identification of pigmented lesions, and OCT angiography for visualizing the microvasculature without the need for contrast-agent. Unlike histology, our platform allows for repeated, non-invasive imaging of live rodents’ eyes and thereby greatly reduces the number of animals required for a study. We have successfully demonstrated the powerful potential of our technology in rodent models of primary retinal degeneration and Alzheimer’s disease. The PoC project OPTIMEYEZ shall now expand our imaging portfolio to include additional models, improve technological aspects, and make our imaging platform accessible to key players in pharmaceutical industry. By securing intellectual property, developing business strategies, and establishing further commercialization concepts together with users from pharmaceutical industry, this project will take our technology from our lab to next generation biomedical eye/brain research.
Digital environment for management of permits and compliance in building and construction (DigiChecks)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Countries involved: Spain,Belgium,Netherlands,France,Austria
Call: Digital permits and compliance checks for buildings and infrastructure (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 6532900.0
EU funding (EUR): 5063743.75
Participants: 15
Project status: CLOSED

DigiChecks proposes to build a digital framework that implements the following steps to overcome the challenges mentioned and pave the way to a more streamlined approach to manage and process permits: Step 1: Standardized Permit Ontology. The first step is to create a shared language for permitting. This language, formalized in a permit ontology, enables the framework to map data from various sources into a common structure and make it processable by a computer in a repeatable manner. Step 2: Digitizing Permit Processes. To deal with the many different actors and their respective processes for permitting, DigiChecks proposes to develop a tool, based on OMG standards, where these actors can model their processes into DigiChecks. These process models can be updated and or removed when the processess change. Step 3: Building Permit Rules. DigiChecks' proposed solution contains the ability for permitting authorities to build their own rules. These rules are used as a base for an automated compliancy checker. Step 4: Integration of the previous steps into a Permit Service (API). To transform the solution into a service, DigiChecks combines steps one (Permit Ontology), two (Permit Process) and three (Permit Rules) into a service offered through an (Open) API. The DigiChecks Permit Service API implements the concepts from the ontology to defined rules and these rules are mapped to a process, thus digitizing the permit workflow. By having an accessible Permit Service, third party developers will be enabled to create new, innovative and reliable permitting applications. The ultimate objective of the solution is to provide flexibility, ease-of-use and efficiency to the permit validation and approval system in the construction project environments. A solution framework is thus required that allows - regardless of the country, region or municipality -, an easy interoperability with the tools commonly used in construction.

Keywords: digital permits,framework,semantic interoperability,ontology,data sovereignty,privacy,blockchain,ids,data space,gaia x,bim,trusted networks
Treating Liver Metastasis (TREATLIVMETS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,France,Italy
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-07-01
End date: 2030-06-30
Duration (months): 72.0
Total project cost (EUR): 10180358.0
EU funding (EUR): 10180358.0
Participants: 6
Project status: SIGNED

Liver metastases commonly develop in up to 50% of patients with various cancer types. The most common cancer that metastasizes to the liver is colorectal cancer (CRC). At least 25% of CRC patients develop colorectal liver metastases (CRLM) during their illness. CRLM represent the major unmet clinical need for this malignancy, as the 5-year survival rate of patients with unresectable disease does not exceed 2%. New therapies that promote antitumor immunity have been recently developed, mostly focusing on enhancing T cell responses. Although these therapies have led to unprecedented successes, only a minority of patients benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in next generation immunotherapies. Given the crucial role of innate immune responses in immunity, targeting these responses opens up new possibilities for tumour control. We hypothesize that the immunotherapy of liver metastases can be significantly improved through harnessing the biology of innate lymphoid cells (ILC), such as Natural Killer (NK) cells and ILC1s, and myeloid cells such as macrophages and DCs. Our team brings together experts in the biology of tissue-resident myeloid (Ginhoux, PI4) and lymphoid (Gasteiger, cPI) cells, in liver immunology (Fumagalli, PI3), and in the development of novel immunotherapeutic strategies that modulate immune cells in the fight against cancer (Vivier, PI2). By combining cutting-edge single cell and spatial transcriptomics of human patient samples with cross-species analyses in advanced genetic mouse models, we aim (1) to identify cellular interactions defining the metastatic tumor microenvironment across murine and human tissue-specimens, (2) to investigate immune cell functions regulating metastatic disease using a unique combination of advanced genetic mouse and human tissue models, and (3) to harness the anti-tumoral functions of innate immune cells via next generation cell engagers.

Keywords: liver immunology,liver metastasis
Towards a World Integrated and Socio-economically Balanced European Economic Development Scenario (TWIN SEEDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Netherlands,Spain,Denmark,Poland,France,Belgium
Call: Towards a new normal? Employment and social impacts of changing supply chains and declining trade intensities (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2707496.5
EU funding (EUR): 2707496.5
Participants: 11
Project status: SIGNED

The objective of the TWIN SEEDS project is to investigate changes in international trade and production patterns, specifically in global value chains (GVCs), both those of a longer-term nature (driven by the "twin seeds": technological developments and geo-political changes) and those that are taking place in the wake of the Covid-19 pandemic. The project will examine the impacts of these changes on employment, job quality, social and regional cohesion, on patterns of growth and competitiveness, as well as their environmental implications. The analysis will provide the basis to map out forward-looking policy scenarios (including trade and investment, industrial, regional, education/training and social policies) that allow Europe to secure decent work and working conditions, rapid progress towards resource-efficiency and decarbonisation, security of supply for strategic goods and sustainable, inclusive and competitive growth in the years to come. The research will be based on a thorough multi-level (global, national, regional, sectoral, firm level) research framework, relying on a mix of quantitative and qualitative methods, on multidisciplinary knowledge (international economists and trade policy experts, regional economists, international business and organisational experts, political scientists) and on an extensive stakeholder engagement.
Systemic approaches to improve cardiometabolic and brain health during lifespan (SYS-LIFE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland,Belgium,Germany
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 3152160.0
EU funding (EUR): 3152160.0
Participants: 5
Project status: SIGNED

Systemic approaches to improve cardiometabolic and brain health during lifespan (SYS-LIFE) is an exciting new postdoctoral fellowship programme that seeks to deliver urgently-needed breakthroughs in the field of cardiometabolic and brain diseases (e.g. heart attacks, strokes, depression and diabetes), promote scientific renewal in this field and develop its future leaders of tomorrow. It is based at the University of Turku (UTU) in Finland and supported by partners in different sectors. UTU’s Collegia have a record for excellence in research and for developing their researchers for leadership roles. SYS-LIFE applies their bottom-up, 'Institute for Advanced Study' model to build on UTU’s outstanding expertise and unique facilities for cardiometabolic and brain health research. It will recruit 11 experienced postdoctoral researchers (ERs) in 2023 and 2024 (22 in total), each for 36 months, through an open, international, competitive, merit-based selection process dependent on external peer-review, in line with the European Charter and Code. Projects that are interdisciplinary, intersectoral, longitudinal or systemic are encouraged. At UTU, such approaches have resulted in major advances in cardiometabolic and brain health. SYS-LIFE offers • Scientific excellence: Fellows will be free to design and pursue novel, high-quality research projects that seek to improve health outcomes in this area, connecting and strengthening research and resources at UTU and beyond; • Career development: SYS-LIFE offers mentoring and a new range of options for non-tenured researchers to develop as future leaders, enabling them to move freely between sectors to acquire unique skills and experiences; • Innovation: SYS-LIFE (i) enables knowledge and technology to circulate freely at regional, national and international levels, (ii) connects intellectual excellence with the practical know-how and infrastructure needed to realise new concepts; (iii) offers dedicated Proof-of-Concept funds.

Keywords: health cardiometabolic brain interdisciplinary intersectoral excellence medicine science technology systemic longitudinal knowledge exchange imaging ai biotechnology mentors fellowship