Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of Tissue Mechanics in Embryonic Self-Organization and Cell Fate Plasticity (MechanoSelfFate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1995334.0
EU funding (EUR): 1995334.0
Participants: 1
Project status: SIGNED

How molecular and mechanical cues interplay to coordinate the morphogenesis and patterning of embryonic structures is an open question in developmental biology. The early avian embryo is an ideal model for the study of such interplay as it exhibits highly regulative development, is greatly amenable to live imaging approaches and can be readily mechanically challenged. Whereas avian embryos have long been known to remarkably adapt and readjust cell fate upon surgical perturbations, such regulative potential has been investigated solely from a molecular standpoint, leaving the role for mechanical forces unexplored. This proposal builds on our recent results and methods characterizing the mechanical control of gastrulation to investigate the role of mechanical forces in embryonic regulation and in cell fate plasticity. Specifically, we propose 1) to develop innovative tools allowing to perturb the mechanical state of early embryos in order characterize the role of forces during development; 2) to test whether a mechanical self-organizing system underlies the remarkable regulative potential avian embryos; 3) to investigate the role of mechanical forces in mesoderm, embryonic and extra-embryonic regional fate allocation. To this end, we will use an interdisciplinary approach combining novel transgenic quail lines, live imaging, and pharmacological/molecular/optogenetic/mechanical perturbations along with theoretical frameworks and modeling approaches. These studies will decipher the interplay between cellular, molecular and mechanical cues that ensures the robust, yet plastic allocation of cell fate in amniote embryos (i.e. reptiles, birds and mammals, including humans).

Keywords: avian,gastrulation,mechanical forces,tissue mechanics
ERA Chair Position for Excellent Research in Oncology (Chaperon)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Czechia
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 2487241.25
EU funding (EUR): 2487241.25
Participants: 1
Project status: SIGNED

The Biomedical Center of the Faculty of Medicine in Pilsen, which has recently been established at the Charles University with support of the European Fund for Regional Development, represents a high-grade regional research infrastructure in the fundamental field of cancer biology and oncology. However, despite its advanced research and innovation performance, the potential of the Center is still not fully exploited, dominantly due to its unsatisfactory attractiveness to top-class researchers, concerning both established experts as well as promising young scientists and PhD students. This represents a major structural weakness of the Center. To directly address this issue, we propose the Chaperon action with the main goal to recruit a world class researcher and research manager to 1) establish and lead new Laboratory of Translational Cancer Genomics filling a thematic gap in the structure of the Center; 2) become the head of Research Programme 2 of the Center, thus strongly boosting its excellence; and 3) take a position in several institutional advisory and supervisory bodies in order to moderate the transformation of human resource policies and managerial processes at the Faculty of Medicine in Pilsen and Charles University on their way to excellence. Attracting high-quality human resources and assuring their sustainability by bringing the institution in close compliance with the ERA priorities and the Regional Smart Specialisation Strategy, the project will substantially increase the research and innovation (R&I) performance of the Center, provide crucial international networking opportunities with respect to all key stakeholders and increase the competitiveness of the institution in obtaining international funding such as ERC. By achieving these goals, the Chaperon ERA Chairs project will help diminish the inequalities in R&I performance within the ERA.

Keywords: research excellence,international funding,era chair,oncology,cancer genomics and epigenomics,institutional changes,translational medicine
European Consortium for Communicating Stem Cell Research (EuroStemCell)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Italy,Italy,Austria,Germany,Spain,Germany,Switzerland,Belgium,Hungary,Poland,Sweden,Sweden,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Health (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2018-03-31
Duration (months): 39.0
Total project cost (EUR): 2251193.23
EU funding (EUR): 600000.0
Participants: 31
Project status: CLOSED

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal www.eurostemcell.org. To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is uniquely placed to maintain and further develop www.eurostemcell.org as a world-leading stem cell information resource, thus meeting the challenge outlined in Topic HOA-6-2014.

Keywords: stem cell research,regenerative medicine,science communication,public engagement,outreach,coordination,network,dissemination
Slovak Academic and Scientific PROgramme for experienced researchers (SASPRO 2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovakia
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 8606520.0
EU funding (EUR): 4303260.0
Participants: 1
Project status: SIGNED

In the proposed project, Slovak Academy of Sciences (SAS), Comenius University in Bratislava (UK BA) and Slovak University of Technology in Bratislava (STU BA) (together participating organisations) intend to build up mobility programme SASPRO 2 for outstanding researchers allowing them to work at their institutions/faculties. It is an extended continuation of the previous successful SASPRO Programme. The main objectives are to create optimal conditions for fellows to perform their research and boost their career as well as to enhance quality of Slovak science and research by increasing excellence of their organisations. Fellows will freely choose from a wide spectrum of host organisations covering technical and natural sciences, life sciences as well as humanities and social sciences. Cross- and intersectoral, multi- and interdisciplinary and international aspects of the individual projects as well as training provided will be strongly emphasized. Top scientists from abroad will be selected for fellowships; fellows will enrich research teams/organisations and they will contribute to raising the quality level of Slovak and European science and research. On the other hand, host/participating organisations will provide all tools for their career and personal development and ensure broadening and deepening of their scientific and non-scientific experience and skills. The results of the programme realisation will be establishing a quality international cooperation network, building and strengthening the bridges between different sectors, finding new approaches to tackle with research topics, training future leading researchers that will transfer the knowledge further and by that strengthen the European science and research position in the world and reduce its fragmentation.

Keywords: mobility,excellence,slovak republic,experienced researchers,incoming,reintegration,multidisciplinarity,intersectorality,transfer of knowledge
The neural basis of path integration memory in insects (PI_Memory_Circuits)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

Many animals make direct trips back to their homes after tortuous foraging trips using a navigational strategy called path integration (PI). During PI, sensory information for direction and distance measurements are used to calculate the straightest path back to home. While PI has been well studied behaviorally, the neural basis of vector memory formation is unknown in any animal. Here, I will combine behavior and physiology to demonstrate PI and the neural basis for vector memory formation in bumblebees. First I will develop real-world behavioral arenas to demonstrate that walking bees use PI. Next, I will use virtual reality to mimic the real-world arenas, demonstrating PI behavior in stationary bees. I will also develop electrophysiological methods to record from neural centers of interest in the brains of restrained bees. Finally I will combine the physiology refined in restrained bees and the PI behaviors in virtual reality to physiologically record from the brains of bees actively performing PI. From these experiments, I will ideally be able to measure the buildup of PI memory and observe how PI memory is used for steering during the homebound part of the foraging trip. From the proposed work, the neural basis of PI will be uncovered for the first time. Navigational feats extending past acquiring and following a home vector may be investigated in the future using the same methods. Results from this work have the potential for gains in applications such as robotics. Finally, during my fellowship, I will gain neuroanatomical and functional tools that will aid in my future research plans to investigate the neural basis of navigation behaviors of mantis shrimp, animals which exhibit similar navigational strategies to those of insects, such as bees, while underwater, with the end goal of uncovering the evolutionary origins of complex, widespread navigational strategies in arthropods and potentially other animals as well.

Keywords: navigation,path integration,insects,central complex,vector navigation,orientation
Cooperate, Communicate and Connect to boost smart Components for tomorrows Industry (Co-FACTOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Coordination and support actions
Partnership: FoF (cPPP)
Countries involved: Germany,Germany,Spain,Germany,United Kingdom,Portugal
Call: Support for the enhancement of the impact of FoF PPP projects (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 319940.0
EU funding (EUR): 319940.0
Participants: 7
Project status: CLOSED

Co-FACTOR aims at speeding-up the industrial up-take of results of the FoF projects I-Ramp3, ReBORN, SelSus, T-Rex, INTEFIX and Power-OM , whose common topic centers around “smart components”. While the prime focus is on gaining benefit for these projects, the proposed measures also seek to link with program level initiatives in a complementary way. Positioning these projects in the core of a larger cluster set-up involving related initiatives as well as the entire stakeholder panorama of the field, Co-FACTOR pursues the 5 major ambitions: Cooperate: establish close partnership among the core cluster to give better visibility to those high-level performing projects among industry, scientific community and policy makers. Communicate: present and promote as a cluster the involved projects and their approaches and achievements among the full range of potential stakeholders as well as public groups and students. Further, to stimulate coherence among “smart components players”. Converge: leverage the impact of the projects by focusing on the cross-cutting issue „smart components“ and assessing reliable and interoperable solutions and standardization opportunities. Connect: facilitate the immediate or short-term exploitation of project results in industrial settings creating a win-win-situation for the technology „push“ and „pull“ site. Consolidate: analyze remaining bottlenecks for „smart components technology“ deployment to formulate thoughtful recommendations for future actions and political framework programs. Co-FACTOR proposes a set of measures spanning from technology assessment, match making among providers and end-user, propelling last-mile exploitation efforts by innovation management and funding outlook, expert workshops, link to research community and roadmapping to outline future R&D&I needs. These will be part of an extensive dissemination campaign featuring intense and strategic communication, organization of events and profound intra-cluster interaction

Keywords: smart components,future manufacturing,i ramp3,reborn,selsus,intefix,t rex,power om,cluster
Establishing stable IRON isotopes of laminated LAKE sediments as novel palaeoclimate proxy (IRONLAKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Under the pressure of human-induced climate change, it is essential to better understand the past natural climate variability. A broader global coverage of high-resolution palaeoclimatic proxy (indicator) data is urgently needed to improve climate projections and adaptation strategies to changing climate and environmental stress. Laminated lake sediments provide invaluable palaeoclimatic information with up to seasonal resolution. The IRONLAKE project aims to develop the innovative methodology of stable iron isotope measurements of laminated lake sediments as a novel proxy for past changes in temperature and wind. Only recently, first studies have hinted that variations in stable iron isotopes of marine and lake sediments reflect changing redox conditions in oceans and lakes, possibly linked to variations in past wind and/or temperature. This project aims to test the hypothesis of a redox-climate-relationship mirrored in iron isotopes. The project will be carried out on existing sediment cores from Lago Fagnano (Tierra del Fuego, Argentina) exhibiting characteristic iron-rich laminae that are most suitable for the approach. In a multidisciplinary perspective, a combination of ultrahigh-resolution micro-facies analysis by thin section microscopy and micro-X-ray-fluorescence elemental scanning will be applied to fully understand the general sedimentological and geochemical processes and, specifically, possible seasonal/climatic variations influencing the formation and deposition of iron-bearing minerals in the lake. The gained knowledge will then be linked with mineral-selective iron isotope measurements to infer the sensitivity of stable iron isotopes to capture climatic variations. The interdisciplinary perspective of this project is designed to advance the innovative field of iron isotope geochemistry and to provide a novel wind/temperature proxy to the palaeoclimate and climate modelling communities .

Keywords: limnogeology,sedimentology,isotope geochemistry in lakes,redox conditions in lakes,high resolution micro facies and xrf analyses,temperature wind redox link
Multi-Use in European Seas (MUSES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Italy,Greece,Poland,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Multi-use of the oceans' marine space, offshore and near-shore: compatibility, regulations, environmental and legal issues (H2020-BG-2016-1, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 1987603.88
EU funding (EUR): 1982104.38
Participants: 10
Project status: CLOSED

The Multi-Use in European Seas (MUSES) project will review existing planning and consenting processes against international quality standards for MSP and compliance with EU Directives used to facilitate marine and coastal development in the EU marine area to ensure that they are robust, efficient and facilitate sustainable multi use of marine resources. The project will build knowledge of the appropriate techniques to minimize barriers, impacts and risks, whilst maximising local benefits, reducing gaps in knowledge to deliver efficiencies through integrated planning, consenting processes and other techniques. MUSES Project - 3 main pillars: 1. Regional overviews which take into account EU sea basins (Baltic Sea, North Sea, Mediterranean Sea, Black Sea and Eastern Atlantic) will be based on an analytical framework to facilitate adoption of a common approach across the sea basins. The progress in implementation of the concept of Multi-Uses in European Sea Basins will be assessed and key obstacles and drivers identified. 2. A comprehensive set of case studies of real and/or potential multi-use will be conducted and analysed to provide a complete spectrum of advantages in combining different uses of the sea. The case studies will create local stakeholder platforms to identify multi-use potentiality, opportunities and limitations. 3. Development of an Action Plan to address the challenges and opportunities for the development of Multi-Uses of oceans identified in the regional overviews and case studies. Provide recommendations for future action, taking into account national, regional and sea basin dimensions. The project will build on work undertaken in other studies including Mermaid, TROPOS, H2Ocean and SUBMARINER. MUSES project partners have direct links with related forums including The Ocean Energy Forum (OEF) which will assist understanding of many issues that need to be addressed at an EU level and could help facilitate and implement the OEF roadmap.

Keywords: multi use,oceans,seas,marine,maritime,spatial,environment,econnomic,societal,planning,blue growth,combined,activities,barriers,benefits,renewable energy,aquaculture
Transforming the future of agriculture through synthetic photorespiration (FutureAgriculture)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Israel,Italy,Germany,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-01-01
End date: 2021-03-31
Duration (months): 63.0
Total project cost (EUR): 4871410.0
EU funding (EUR): 4871410.0
Participants: 5
Project status: CLOSED

For a new green revolution to feed the continually increasing population, agriculture productivity will have to be significantly improved. Photorespiration represents a big challenge in this respect, because it dissipates energy and leads to the futile loss of CO2, thereby limiting plant growth yield. Implementing an efficient metabolic bypass for photorespiration can therefore increase the photosynthetic efficiency of many cultivated crops. Several such routes were previously proposed. However, these routes were limited to existing enzymes and pathways and provided only partial improvement. Here, we propose a radically different approach: to engineer entirely novel CO2-neutral or CO2-positive photorespiration bypasses based on novel enzyme chemistry that support significantly higher agricultural yields. These bypass routes could support 60% higher biomass yield per turn of the Calvin Cycle and >30% higher yield per ATP. Our project innovatively integrates different research disciplines and combines academic research with industrial implementation. In silico studies will integrate biochemical logic and pathway modelling to explore all possible photorespiration pathways and identify the most efficient routes. In vitro research will establish novel enzyme functions via enzyme engineering and directed evolution. Full pathways will be reconstituted and optimized in vitro using a novel mass spectrometry based platform. High in vivo activity will be selected by implementing the pathways in engineered E. coli strains. Enhanced photosynthetic efficiency will be demonstrated in cyanobacteria expressing the synthetic pathways. Finally, the most promising synthetic pathways will be implemented in higher plants and growth phenotypes will be monitored. The proposed project comprises a significant advance in synthetic biology – applying biochemical principles to modify the very core of carbon metabolism with synthetic pathways that carry multiple novel enzymatic functions.

Keywords: photosynthesis,carbon fixation,biological efficiency,enzyme engineering,metabolic engineering,agriculture yield