Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Connected Open Identifiers for Discovery, Access and Use of Research Resources (FREYA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Australia,Germany,Switzerland,United States,Netherlands,United Kingdom,United Kingdom
Call: Platform-driven e-infrastructure innovation (H2020-EINFRA-2017, 2017)
Start date: 2017-12-01
End date: 2020-11-30
Duration (months): 36.0
Total project cost (EUR): 5246117.5
EU funding (EUR): 4998650.0
Participants: 13
Project status: CLOSED

The goal of the FREYA consortium is to iteratively extend a robust environment for Persistent Identifiers (PIDs) into a core component of European and global research e-infrastructures. The resulting FREYA services will cover a wide range of resources in the research and innovation landscape and enhance the links between them so that they can be exploited in many disciplines and research processes. This will provide an essential building block of the European Open Science Cloud (EOSC). Moreover, the FREYA project will establish an open, sustainable, and trusted framework for collaborative self-governance of PIDs and services built on them. FREYA capitalises on the successes of the THOR project and will build on the core services of the existing trusted PID systems of the project partners, developing them in the context of established community-based services and more widely through the EOSC. The FREYA e-infrastructure components will be built on technologies and services that are already well proven. New services, and new PID types, will be introduced and moved up the scale of Technology Readiness Levels, so that the emerging e-infrastructure services are prototyped and positioned for evolution beyond the end of the FREYA project. The vision of FREYA is built on three key ideas: the PID Graph, PID Forum and PID Commons. The PID Graph connects and integrates PID systems to create an information map of relationships across PIDs that provides a basis for new services. The PID Forum is a stakeholder community, whose members collectively oversee the development and deployment of new PID types; it will be strongly linked to the Research Data Alliance (RDA). The sustainability of the PID infrastructure resulting from FREYA beyond the lifetime of the project itself is the concern of the PID Commons, defining the roles, responsibilities and structures for good self-governance based on consensual decision-making.

Keywords: e infrastructure,persistent identifiers,research data
A revolutionary and patented compact device that recovers the majority of the heat from waste water in residential and commercial places (Obox)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hot water costs a lot of energy to heat, yet most of that heat goes down the drain. Due to lack of effective and efficient solutions at small scales in residential buildings and small businesses, still a huge amount of energy is wasted for heating the water. In Europe alone, that’s a €15B waste every year and this is as high as €18B in North America. Current solutions are mostly focusing on more efficient boilers and not heat recovery, and the heat recovery solutions don’t have high efficiency and are suffering steady loss of efficiency therefore their payback periods are so long. EHTech developed and patented a fully automatic filter-less system, Obox®, which recovers 71% of the heat and use it to heat the water again therefore, cuts the hot water bill by 63%. Using Obox® will lead to major saving in energy (264TW/yr) and CO2 emissions (150 million tons of CO2/yr) if every dwelling in EU28 is equipped with an Obox®.

Keywords: heat recovery,green energy,sustainable energy,patented technology
Sources and sinks for excess Xe and Ar on the Moon (XeMoon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Noble gases trace the evolution of reservoirs inside terrestrial planetary bodies because their isotopic signatures are diagnostic of volatile sources. In addition, original compositions can be modified by radioactive decay of rock forming elements, providing constraints on the chemistry of an interior reservoir and the time at which it was isolated (since when noble gases were retained). Some lunar samples are known to preserve signatures in xenon and argon that were degassed from one or more interior sources to the exosphere, then incorporated into the regolith, potentially allowing this record to be read. In this work I will combine (i) my expertise in lunar evolution, sample characterization and the 40Ar-39Ar system, (ii) the University of Manchester’s expertise in xenon isotope systematics, world-leading instrumentation for xenon isotopic analysis and state-of-the-art sample characterisation facilities, and (iii) expertise relevant to the lunar exosphere from a network of collaborators. With this team, I will (i) determine the range of xenon and argon signatures in lunar regolith samples and the times at which they were incorporated, (ii) develop a model of the lunar exosphere to infer source reservoir compositions from those measured in samples and so (iii) investigate the number of contributing lunar reservoirs, their compositions and their histories. The results of this interdisciplinary study will be disseminated to the range of specialist and non-specialist audiences. They will serve to test models of lunar evolution, allow comparison with the Earth and Mars to gain wider understanding of terrestrial planetary bodies, and stimulate engagement with planetary science. Additionally, I will develop my leadership and teaching skills by completing the University of Manchester’s New Academics Programme, equipping me to move to the next stage of my career as a researcher, leader and teacher for the next generation of multidisciplinary planetary scientists.

Keywords: lunar exosphere,xe and ar isotopes,cold traps,polar permanently shadowed regions
Development of photoswitchable ligands for the reversible and selective assembly with RNA (PHOTORNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The proposed project aims at the development of novel functional ligands whose association with ribonucleic acid (RNA) is reversibly activated by light. As several RNA forms are essential key elements in physiological processes, the control of their function or malfunction by the reversible binding of photoswitchable ligands possesses a great potential as a tool in anticancer, antiviral and antimicrobial therapy. Surprisingly, this innovative approach towards a controlled reversible generation of RNA binders was mainly neglected in this highly topical research field. Hence, in this project photochromic hemi-indigo and fulgide derivatives are chosen as a platform for the design of photo-responsive RNA ligands, because i) they exhibit general features of RNA binders; ii) their structure can be reversibly modified by light, iii) the core structures are readily synthesized, and iii) the substitution pattern can be easily varied to enable fine-tuning of binding selectivity based on structure-activity relationships. In addition, conjugates that comprise two photoactive RNA-binding units will be obtained and studied because such bifunctional binders are expected to have very high affinity and selectivity toward RNA. An extensive library of derivatives will be synthesized and tested for their photocontrollable association with RNA. As a special method, real-time NMR-spectroscopic studies with direct irradiation of the sample inside a specifically designed spectrometer will be used to assess in detail the dynamics in the course of the photoinduced ligand–RNA interactions. Overall, it is anticipated that this systematic approach will enable the identification and development of lead structures for controllable RNA-targeting drugs with a great pharmacological potential. Moreover, the high interdisciplinary, innovative character of this challenging project gives the researcher an excellent opportunity to achieve professional maturity and open up best career possibilities.

Keywords: bioorganic chemistry,rna binders,photochromism,photoswitches,hemi indigo,hemithioindigo,fulgide,fulgimide
Engineering Composite Tissues for Facial Reconstruction (VesselNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2025-08-31
Duration (months): 72.0
Total project cost (EUR): 2375000.0
EU funding (EUR): 2375000.0
Participants: 1
Project status: SIGNED

Facial reconstruction usually involves the use of autologous grafts or composite tissue allografts, which are highly complex tissues that pose significant challenges to tissue engineering experts. Tissue engineering of independent facial elements, e.g., bone, adipose, skin and muscle tissues, has been demonstrated. However, to date, no composite soft tissues composed of multiple facial layers have been created. Composite facial tissue engineering will require proper innervation and vascularization, essential to support generation of large thick implants. However, techniques for effective innervation of engineered tissues are currently insufficient and generation of well-vascularized large and thick engineered tissues is still one of the major obstacles limiting their translation to the clinic. Our goal is to engineer thick, composite, human-scale, facial tissues (muscle-adipose-dermis composite, and bone) of a personally adaptable shape, that will be vascularized in-vitro, and innervated upon transplantation. Our concept is to create in-vitro a functional vascular network (VesselNet), composed of both large and small vessels, within engineered constructs, which will allow for the generation of thick engineered tissues under continuous flow conditions. 3D bio-printing techniques will be applied to create the engineered tissues. These tissues will serve as a model to study mechanisms involved in vessel anastomosis, and tissue organization and stabilization. The applicability of the engineered composite soft and bone tissues will be evaluated in facial, breast and abdominal wall defect reconstruction models, and in an open fracture model. Such engineered large-scale composite tissues are expected to have a major impact on reconstructive surgery and will shed light on yet unknown tissue organization mechanisms.

Keywords: engineered thick composite tissues,vascularization,muscle,bone,adipose,innervation,3d bio printing,reconstructive surgery
Global Science Communication and Perception (GlobalSCAPE)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Ireland,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2020-1, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 1199937.5
EU funding (EUR): 1199937.5
Participants: 6
Project status: CLOSED

The principal aim of GlobalSCAPE is to generate a detailed picture of science communication in a global context. Recent research focused on taking stock and re-examining the role of science communication has concentrated primarily on science communication in Europe and the western world. GlobalSCAPE expands outwards from this to take stock of the lesser-heard voices: the science communicators working in non-western countries and in regions where taking stock of science communication is particularly difficult. The experiences of science communication professionals in these regions have traditionally been under-represented. GlobalSCAPE will ensure that a full and accurate picture of global science communication can be established. The central component to the methodology implements a large-scale programme of automated diary studies to gather perspectives of science communication professionals. Those perspectives and variations will be mapped over time, providing a powerful tool for analysis. The landscape and modes of science communication are changing. This is, in large measure, the result of advances in digital communication in combination with ready and widespread access to smart devices. In its methodology, GlobalSCAPE builds on the very technologies that are changing this landscape. It exploits the global ubiquity of smart devices to implement an innovative and large-scale programme of data collection through the use of state-of-the-art methods in automated diary studies and draws on the expertise of a multi-disciplinary and international team of partners. GlobalSCAPE will: 1. Present a more complete and fine-grained picture of global science communication 2. Map that picture over time to identify shifts in priorities and incentives/disincentives 3. Innovate a new and ambitious methodology to measure and assess science communication 4. Maximise the resources of SwafS-19 to support the work of science communicators where it is most needed

Keywords: global science communication,diary studies
Beating Complexity through Selectivity: Excited state Dynamics from Anti-Stokes and non-linear resonant inelastic X-ray scattering (EDAX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany,Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 2496250.0
EU funding (EUR): 1909690.0
Participants: 3
Project status: CLOSED

The key to move from a mere description of static materials properties to the determination and control of functionality and chemistry lies in understanding dynamic pathways through multidimensional energy landscapes. Through my efforts over the last decade my group accomplished breakthroughs towards the required excited states selectivity and to follow dynamic pathways with resonant inelastic soft x-ray scattering (RIXS) in three aspects: Non-linear RIXS for materials science to boost scattering efficiency. Time resolved and Anti-Stokes RIXS for back-ground free detection of excited states. Sub-natural line width RIXS to map out potential energy surfaces at selected atoms. In the ERC research I link these unfolding fields and combine them with ab-initio treatment of excited states to create unprecedented back-ground free X-ray probes of excited states of matter and their dynamics. This will be femtosecond time resolved Anti-Stokes RIXS for excited state selectivity with transform limited pulses and doubly resonant soft X-ray 4 wave mixing to determine multi-center dynamics on atomic scales. The ERC grant will answer long standing questions on the governing principles of functionality, regarding chemical pathways and energy landscapes in molecules as well as phase transitions, driven phases and emergence in functional materials. These novel approaches become only now feasible through the unprecedented brilliance of Free-Electron Lasers and the efforts of my group over the last decade. The ERC grant will establish proof-of-principle at brilliant soft X-ray Free-Electron Lasers that will be followed by world leading, ideal conditions implemented at the European XFEL.

Keywords: soft x ray spectroscopy with free electron lasers and synchrotron radiation,european xfel,non linear x ray matter interaction,ultrafast switching,femtochemistry
Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2 (Pharmcophore-DOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy. The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators. The researcher will acquire novel technologies and develop new skills in both scientific and management aspects, which are important in his professional maturity and career plans; while the host can also be benefitted from his experience in medicinal chemistry. This action will promote the mobility inside the European Research Area and spark lasting cooperation among different European countries.

Keywords: diversity oriented synthesis,pharmacophore model,protein protein interactions,rad51 brca2,cancer,resistance
A disruptive mobile photovoltaic array that can pack up to 20kWp of generating power into a domestic trailer and 100kWp of generating power into an ISO 20-foot shipping container. (RollArray)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Transient power generation in remote locations is cost-intensive and subject to fuel shortages, and renewable alternatives are unable to compete with diesel generators used at these sites, either in terms of durability or generation capacity. The Renovagen RollArray is a rollable thin-film solar array using cutting-edge photovoltaic technology. Each rolling solar array integrates battery banks to provide continuous energy outside of solar peak times, and motorised re-spooling to allow rapid redeployment. RollArray systems are capable of providing up to 100kWp of electrical power, and offer superior low-light performance to contemporary mobile PV solutions. This makes them perfectly suited to exploratory and disaster situations where consistency and stability of power supply are paramount, due to a high financial and potential unacceptably high human cost, respectively. RollArray eliminates the fuel transport costs and environmental concerns of diesel generator use, does not require a solar engineer for set-up, deploys in less than 10 minutes, and provides up to 10x the generating capacity of other mobile PV solutions.

Keywords: solar power,mobile solar power,photovoltaic,emission reduction,renewable energy,green energy,efficiency,remote generation,remote power supply,off grid energy,disaster response
ThermoEye an innovative system for pigs' fever early detection (ThermoEye)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global pork market is worth over €100B. The pigs’ breeders use preventive drugs to reduce risk of illnesses spreading and to increase their profits by 10%. Only in Poland farmers use yearly over 580 tons of pure antibiotics, which we later consume in meat or which pollute the environment causing antimicrobial resistance. Research shows that 80% of drugs are applied to animals therefore the probability that a given bacteria is immune to human drugs is very high. Officially more than 46% pig's farms used the preventive medicines (unofficial data shows that the number is twice higher). Additionally there is a lack of qualified veterinarians on the market who could monitor the farms. Until know there were no complex solution which address these challenges. ThermoEye is game changing innovation. After two years of experiments our engineers have designed a distributed, contactless IoT system for temperature monitoring based on cheap bolometric sensors (currently TRL7 with real tests). ThermoEye detects fever at early stage and helps farmers to protect herds in alternative, ecological friendly way without preventive antibiotics. The farmers' investment in ThermoEye returns in 18 months. The end customers receive antibiotic-free pork, and the vets obtains new tools for herd monitoring. Moreover we provide the statistical analysis for researchers. ThermoEye is a WIN-WIN-WIN solution for stakeholders providing income of €1/pig/month for our company. There are above 760M over the world. Smart Soft Solutions team has started in Poland, but we would like to be a global company. We won several competitions like MIT EF, Young in Lodz, EIT Food and we have seed investors on board who evaluated our product and business model. We presented our solution in Dubai, Bucharest, Hannover and other fairs to create book of orders. First sales was done last month. Recently EU Parliament banned preventive antibiotics usage since 2022 and it will strongly supports our company mission.

Keywords: thermography,illness detection,cloud computing,asf detection,remote monitoring system,bolometric sensors,embedded systems