Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modulating Tregs in liver disease for therapeutic benefit (MOD-REG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 269414.4
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Regulatory T cells (Tregs) are important for maintaining tolerance to self and are known to contribute to appropriate priming in the case of foreign challenges, however, their role in liver homeostasis and disease remains to be determined. Liver disease represents a significant global health issue with Hepatitis B Virus (HBV), Metabolic dysfunction-associated Steatotic Liver Disease (MASLD), and Hepatocellular Carcinoma (HCC) resulting in considerable morbidity and mortality worldwide and limited treatments are available to address these conditions. This project aims to identify novel mechanisms of targeting Tregs in liver disease to suggest methods to manipulate these cells for therapeutic benefit. Cutting-edge mouse models of HBV, MASLD, and HCC will be used to determine the phenotypes, kinetics, and localisation of Tregs in the liver under homeostasis and during disease. High parameter flow cytometry, spatial transcriptomics, and state-of-the-art intravital imaging will allow us to investigate high-resolution spatiotemporal dynamics of liver Tregs to identify novel molecules, interactions, and functions of these cells. Tissue samples from human patient HBV and HCC cohorts are available to the host lab and can be used to screen and refine the molecules of interest identified in mouse liver Tregs to focus further investigation on clinically relevant molecules. The role of Tregs in T cell priming in HBV, and effects on MASLD progression, and HCC development will be determined using mouse models to specifically deplete Tregs, or delete molecules of interest in Tregs, at defined disease stages. Overall, this project will significantly advance our understanding of Tregs in the liver and has the potential to reveal promising clinical targets. The training in experimental techniques, research communication, and transfer of knowledge my career will be developed towards my goal of becoming an independent researcher.

Keywords: tregs,hepatitis b virus,non alcoholic fatty liver disease,hepatocellular carcinoma
Discovering the causes of three poorly understood cancers in Europe (DISCERN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: France,Netherlands,Czechia,Spain,Belgium,Italy,Poland,Norway,United Kingdom,Sweden,Estonia
Call: Better understanding of the impact of risk factors and health determinants on the development and progression of cancer (HORIZON-MISS-2021-CANCER-02, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 8857814.0
EU funding (EUR): 8857813.0
Participants: 20
Project status: SIGNED

The overall goal of DISCERN is to understand the causes of three poorly understood cancers in Europe; renal, pancreatic and colorectal cancer, and help to explain their geographical distribution, including their high incidence in central and eastern Europe. This will be achieved by combining large-scale European biorepositories comprising population-based cohorts and tumour case-series with state-of-the-art molecular profiling techniques and machine learning approaches. In particular, DISCERN will identify potential new causal risk factors for the three cancers using novel exposomics and proteomics scans, as well detailed geospatial and environmental exposure information from 16 large-scale epidemiological cohorts including almost 900,000 individuals. It will also explore biological mechanisms on how these risk factors are potentially causing these cancer types with a focus on promoting factors in normal tissues using deep sequencing, single cell multi-omics and spatial proteomics. The causal effects of identified cancer risk factors and the cellular signalling responses they trigger will be further evaluated using a panel of stem cells and colon, renal and pancreatic 3D organoids. The results from DISCERN will be disseminated to citizens, patients and policy makers through collaborating patient and participant organizations. DISCERN will provide the critical evidence base required to develop new prevention strategies to tackle the growing burden of renal, pancreatic and colorectal cancer in Europe. This action is part of the Cancer Mission cluster of projects on "Understanding".

Keywords: cohorts,exposome,biobanks,disease determinants,risk factors,proteomics,genomics,patient advocacy,mechanistic studies,colorectum,pancreas,kidney
Evidence and Solutions for improving SPONGE Functioning at LandSCAPE Scale in European Catchments for increased Resilience of Communities against Hydrometeorological Extreme Events (SpongeScapes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Netherlands,United Kingdom,France,Italy,Slovenia,Poland,Greece,Germany
Call: Boost the sponge function of landscape as a way to improve climate-resilience to water management challenges (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2613856.25
EU funding (EUR): 2613856.25
Participants: 11
Project status: SIGNED

SpongeScapes aims to consolidate, expand and disseminate scientific knowledge to improve the sponge function of soil, groundwater and surface water systems to accelerate the appropriation by all stakeholders. SpongeScapes will contribute to enhancing climate resilience against hydrological extremes at landscape scale: We will review and demonstrate the effectiveness of solutions in 140 existing cases, further detail process understanding in X individual case studies, and upscale this knowledge together with stakeholders by co-designing sponge strategies on landscape scale. We bring individual solutions and strategies for upscaling closer to the market by providing realistic evaluations of their effectiveness under different hydrometeorological extreme events in current conditions and future scenarios. We provide stakeholders with methods to map opportunities and self-assess the potential for increasing sponge functioning of groundwater, soils and surface water systems within the local context, taking climate, geology, topography, soil characteristics and land-use into account. The wide variety of sponge measures and strategies provided by the X case studies enables assessments of their primary functioning, co-benefits and potential trade-offs, and suitable governance and policy environments for implementation. Using validation data from case studies, SpongeScapes improves state-of-the-art, open source (geo-)hydrological modelling tools and enhances the quantification of sponge strategy impact assessments linking detailed process understanding to landscape scale evaluations. In the case studies we will collaborate with a various public and private stakeholders directly impacted by, or involved in, changes relating ot improving sponge functioning at the landscape scale. Stakteholders include local decision-makers and community groups, who are directly impacted by changes related to sponge functioning on landscape scale.
SPIKING PHOTONIC-ELECTRONIC IC FOR QUICK AND EFFICIENT PROCESSING (SPIKEPro)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Germany,Belgium,United Kingdom,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2632778.75
EU funding (EUR): 2632778.75
Participants: 6
Project status: SIGNED

Rapid advances in artificial intelligence technologies have led to powerful models and algorithms that have revolutionized many applications across all fields of science and technology. Deep learning performed within artificial neural networks has yielded new ways to process data, leading to sophisticated systems with impressive functionality and benefits. However, conventional computing hardware is reaching its limits in terms of energy efficiency and speed. A new approach to computing hardware is needed. Novel brain-inspired or neuromorphic chips working with biologically-inspired spiking neural networks have gained attention as they promise highly efficient ways to process data. Important research effort has been dedicated to develop such neuromorphic systems in electronic or photonic hardware separately, each with its drawbacks and limitations. SPIKEPro proposes a science-towards-technology breakthrough by combining low-energy electrical and photonic neurons into a joint spiking neural network on an integrated circuit. SPIKEPro’s chip integration approach is based on a common technology platform, connecting ultrafast laser optical neurons with efficient electrical spiking diodes through non-volatile synaptic weights. This enables to simultaneously capitalise on the advantages of both electronics and photonics to deliver efficient and high-speed SNNs going beyond existing implementations. In addition to reducing the energy consumption per spike in the network, SPIKEPro will also develop novel learning strategies and algorithms able to work with reduced number of synaptic connections. These will be possible by exploiting the hardware parameters of the electrical and photonic spiking devices. The outcome of SPIKEPro will have lasting economic, societal and scientific impact. The project will bring ultra-fast and efficient neuromorphic hardware into the disparate fields of edge computing, sensor data processing, high-speed control and computational neuroscience.

Keywords: neuromorphic computing,spiking neural network hardware,brain inspired computing
Choice, necessity or chance? Understanding behaviouR chanGE iN Transport (URGENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2028-09-30
Duration (months): 72.0
Total project cost (EUR): 1936613.0
EU funding (EUR): 1936613.0
Participants: 1
Project status: SIGNED

Despite various soft and hard measures as well as improved transport technologies, carbon emissions from transport are not decreasing. URGENT will provide the knowledge base for more effective intervention strategies. To this end, the project examines under which individual and contextual circumstances people change their mobility behaviour and what mental mechanisms are involved in these behaviour change processes. The project uses a holistic interdisciplinary approach based on a unique longitudinal dataset. Over a 3-year period, data will be collected via a bi-annual survey combined with case studies including sub-samples of survey participants. Based on the survey, in-depth interviews and an intelligent mobility diary app, the case studies examine how people adapt their mobility behaviour in prospect and response to: (1) residential relocation, (2) anticipated vs. sudden life events and (3) transport technology adoption. Applying causal machine learning methods, the project will uncover which personal, social, technical or spatial factors are most relevant initiators of behaviour change and will specify the causal relations between involved factors, informed by the case studies. URGENT will additionally examine rebound effects of changed mobility behaviour (e.g. car use reduction, electric vehicle adoption) and reveal under which conditions, and to what extent, behaviour change in one area (e.g. commuting) positively or negatively spills over to other areas (e.g. air travel, food consumption). URGENT applies a novel analytical strategy that cross-fertilizes concepts from psychology (behaviour change models), human geography (mobility biographies approach), sociology (mobility cultures) and machine learning (causal discovery and causal inference). The project will not only fundamentally increase the understanding of behaviour change in transport, but also bears the potential to lead to a breakthrough in studying causality in transport research at large.

Keywords: behaviour change mobility behaviour sustainable transport modal shift causality attitude behaviour relationship transport technology adoption mobility biographies mobility culture travel socialisation life event retirement,e bike,electric vehicles
Human-specific modifiers of synapses in development, plasticity and disorders (synMODIFIERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The function of the brain relies on an intricate network of neurons connected by synapses that enable us to feel, think, learn, act, communicate and adapt our behavior to the ever-changing world. Although the molecular composition and organization of synapses are overall conserved across mammals, a large body of evidence indicates that synapses are differentially regulated in humans. This specialization of human synapses is at the heart of what makes us human. It contributes to the increase in connectivity that characterizes the human neocortex. It also extends the period of synaptic maturation during which cognitive and social experiences sculpt developing cortical circuits and many neurodevelopmental disorders manifest. In this project, we will test the hypothesis that human-specific genetic innovations enhance the role of the environment in the development of synapses in cortical circuits and impact the pathophysiology of neurodisorders. Building on recent advances in our understanding of the human genome, we will determine how human-specific genetic innovations modify the cell biology of synapses, from synaptic connectivity and maturation to synaptic plasticity and pathological dysfunctions. We will combine cutting-edge mouse and human models compatible with investigation of synapse cell biology in integrated circuits together with a multidisciplinary approach based on in vivo molecular manipulations, electrophysiology, microscopy and omics technologies. This will allow us to gain a comprehensive understanding of fundamental mechanisms and illuminate species differences between mouse and human at the synapse and in neurodisorders, in a way not previously possible and with broad implications for the development of therapeutic strategies.

Keywords: molecular and cellular neurobiology,synapse,synaptogenesis,synaptic plasticity,dendritic spines,trans synaptic interactions,atypical neurotransmitter receptors,synaptic organizers,protein synthesis,translation,neuronal morphogenesis,axonal development,assembly of cortical circuits,human specific genes,human brain evolution,neurodevelopmental disorders
Geometric and Low-regularity Integrators for the Matching and Preservation of Structure in the computation of dispersive Equations (GLIMPSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 156088.16
EU funding (EUR): 156088.16
Participants: 1
Project status: CLOSED

If mathematics is the language of physical sciences, differential equations are their grammar. Yet, to understand them, we need computational algorithms. Some of the most intriguing phenomena in nature arise when the underlying physical laws can be described using nonlinear dispersive partial differential equations. This means that waves of different frequencies travel at different speeds -- a mechanism that is, for instance, responsible for the breaking of ocean waves near the shore. When a computer is asked to approximate solutions that exhibit discontinuities (low-regularity), as is the case for instance in shock waves, these nonlinear frequency interactions pose a significant challenge which has recently been addressed by the development of so-called resonance-based numerical schemes. In many applications, it is desirable to apply geometric numerical integrators -- algorithms that preserve geometric structure of the underlying equation such as conservation of energy or time reversibility. However, there is only a very limited set of methods available that can address both challenges in unison, i.e. perform well in low-regularity regimes and preserve geometric structure of the underlying differential equation. Such algorithms, if more widely developed, would provide a valuable tool for a range of applications, including extreme events in ocean waves and atmospheric models. The goal of this proposed research is to address this need for structure-preserving low-regularity integrators for dispersive partial differential equations. The proposed project lies at the interface of computational mathematics, analysis and physical applications and, if successful, the results of this proposal have the potential to enhance both our current understanding of numerics for dispersive equations and, in the medium term, improve practical simulations which are used in weather forecasting and efficient disaster prevention from extreme ocean events.

Keywords: nonlinear dispersive partial differential equations time evolution equations low regularity phenomena geometric structure preservation simulation of wave phenomena
A multiscale approach to unsaturated flow in porous media with Preisach hysteresis (MulPHys)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Czechia,Germany,Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 3
Project status: SIGNED

Experimental evidence indicates that fluid filtration through unsaturated porous media exhibits a hysteretic behavior, originating at a microscopic level from surface tension at the point of contact between water and air in the pores. As a result, the pressure-saturation constitutive relation turns out to be of hysteresis type, accurately described with the Preisach operator by a thorough fitting procedure. The main objective of the MulPHys project is to expand the knowledge about Preisach hysteresis for fluid filtration and build new mathematical models for unsaturated porous media, employing a multiscale approach. The suitability of the Preisach operator in describing the hysteretic behavior of unsaturated porous solids sparked an intense research effort in the community of experts in PDEs with hysteresis, with the goal of including the Preisach operator in mathematical models. In these endeavors, the presence of a microstructure was neglected, with the approach being directly macroscopic. Another branch of research has considered porous media as objects with a microstructure, and has derived the macroscopic description of fluid flow from local behavior. In this body of research, however, porous media are often assumed to be completely saturated so that no hysteresis can occur. With MulPHys, we will fill the gap between these two research areas, employing homogenization techniques to provide a justification of the Preisach operator as the correct tool for describing filtration. Particular attention will be paid to including gravity effects and understanding solid-liquid interactions at the microscopic level. Numerical simulations and experimental data will be instrumental in achieving these objectives. Potential applications in the preservation of historic buildings are foreseen, thus addressing a European priority and implying significant impact not only for the scientific community, but also for the professional sectors and society as a whole.

Keywords: hysteresis,homogenization,microstructure,unsaturated flow