Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cartilage progenitor cells for growth plate regeneration (Grolaries)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2022-04-02
Duration (months): 30.0
Total project cost (EUR): 204415.68
EU funding (EUR): 204415.68
Participants: 2
Project status: CLOSED

Growth plate injuries result in growth arrest, formation of a “bony bar” and angular limb deformities in children. Novel therapeutic approaches directed towards prevention of bone formation and growth arrest have to integrate cellular grafts, biomaterials and growth factors with the ultimate goal of recapitulating the complex zonal organization of the growth plate. One endogenous source of cartilage progenitor cells is thought to be the resting zone of the growth plate. Until now, the lack of specific marker(s) for the resting zone restricted the examination of this population. In the proposed research, I aim to label and trace these cells during postnatal growth and in reaction to trauma, and I aim to understand: whether resting zone cells express skeletal stem cells characteristics (Aim 1), whether they are expandable and multi-potent (Aim 2) and whether they contribute to regeneration of the growth plate in a physeal fracture model (Aim 3). Clinical translation of chondrocyte stem cell regeneration necessitates basic validation in human tissue of the cell surface markers found in mouse stem cells. This last step in the project will be performed in collaboration with Dr. Fernando Santos Laboratory at University of Oviedo, Spain. Altogether, these results will provide a strong basis for development of bioengineering strategies for growth plate cartilage restoration. Finally, this collaboration between Dr Andreia Ionescu Lab and Dr Laboratory would provide not only an interchange between American and European laboratories, basic and clinical science, but also a robust criterion for identification of a stem cell population instrumental for the development of future therapeutics.

Keywords: growth plate,stem cell,regeneration,mouse
Forward-looking socio-economic research on Energy Efficiency in EU countries. (HERON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Italy,Estonia,Germany,Serbia,Belgium,Bulgaria,Greece,United Kingdom
Call: Socioeconomic research on energy efficiency (H2020-EE-2014-2-RIA, 2014)
Start date: 2015-05-01
End date: 2017-11-30
Duration (months): 31.0
Total project cost (EUR): 958750.0
EU funding (EUR): 958750.0
Participants: 8
Project status: CLOSED

HERON aims at facilitating policy makers of multi-level governance in EU, to develop and monitor energy efficiency policies in building and transport sectors, through forward-looking socio-economic research in seven EU and one candidate countries. The objectives are: i. the impact of socio-economic and institutional factors on implementing energy efficiency policies and measures, ii. the development of energy-efficient pathways to the horizon 2030 and beyond taking into account the socio-economic drivers and the updated energy efficiency measures, iii. the contribution to improving energy modeling by incorporating social, educational and cultural factors so as to reflect the end-user behavior, iv. the establishment of communication channels between researchers, decision makers of different governance levels and social and market stakeholders. These objectives will be achieved through: (1) Mapping of energy efficiency policy instruments, available technologies and social, economic, cultural and educational barriers in transport and buildings, (2) Assessment of the evidenced barriers and the main driving factors, in order to define their weight/importance for the implementation of energy efficiency policies, (3) Determination of linkages between the factors and the energy efficiency, (4) Forward-looking scenario analysis, focusing on macro- and micro-economic impacts of energy efficiency policy options, (5) Policy recommendations through multi-criteria evaluation and feedback mechanisms with policy makers and market stakeholders from EU (member states, Covenant of Mayors) and neighboring countries (Business Council of BSEC). HERON will develop an innovative decision support tool to incorporate non-economic and non-market elements, such as social, educational and cultural, into scenario analysis.

Keywords: buildings,transport,policy tool,socio economics
eXclusions of Environmental vibrations affected by Railway Operations using metamaterials (XeRo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-21
End date: 2025-12-30
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

With the rapid development of high speed rail system, ground vibration mitigation solutions are desperately needed. As a novel vibration mitigation method, metamaterial can theoretically yield excellent performance in shielding dynamic waves in broad frequency bands. However, the application of metamaterials in railway-induced vibration mitigation is a very recent and ongoing topic. Therefore, the XeRo project aims to establish new and practical contribution towards a better understanding of the mitigation effects by metamaterials for railway-induced environmental vibrations. The experienced researcher (ER) will: 1) investigate the dominant frequencies of railway environment based on a 3D coupled train-track-soil interaction model; 2) design and develop the metamaterial based on the locally resonant mechanism; 3) characterize and optimize the metamaterial with respect to viscoelastic multi-layered soils; and 4) demonstrate the mitigation effect of the metamaterial on railway environmental vibration. Implemented at the University of Porto, and supervised by Prof Rui Calcada, the XeRo project will allow the ER to diversify her individual competence by developing skills in railway dynamics, academic dissemination and networking; student supervision; and research management and leadership. The XeRo project will also strongly benefit the ER’s inter-sectoral and interdisciplinary expertise and strengthen her international network considering a secondment will be carried out at the University of Birmingham. A two-way transfer of knowledge is guaranteed since the XeRo project combines the ER’s expertise in metamaterial design and railway vibration evaluation and the host’s expertise in the numerical modelling and dynamic analysis of train-induced ground vibrations. Therefore, the XeRo project will contribute to Europe’s knowledge-based society, policy makers and rail industries by providing invaluable knowledge on the novel vibration mitigation solution in railways.

Keywords: railway dynamics,metamaterial,ground vibration mitigation,train track soil interaction
Commercial service platform for user-relevant coastal water monitoring services based on Earth observation (CoastObs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Italy,Hungary,France,Netherlands,Netherlands,United Kingdom
Call: Downstream applications (H2020-EO-2017, 2017)
Start date: 2017-11-01
End date: 2021-04-30
Duration (months): 42.0
Total project cost (EUR): 2306911.25
EU funding (EUR): 1968614.38
Participants: 8
Project status: CLOSED

Coastal zones are very productive areas, offering many valuable habitats and ecosystems services and attracting human settlements and activities. The intensive concentration of population and excessive exploitation of natural resources puts high pressure on coastal ecosystems leading to biodiversity loss, habitat destruction, pollution as well as conflicts between potential uses and space competition. Several European directives aim at sustainable management of coastal waters, retaining or restoring a high ecological status and safeguarding ecosystem services. Increasing pressure and stricter regulations increase the need for efficient monitoring solutions. Where traditional in situ sampling is insufficient to characterise the highly dynamic coastal environments, Earth Observation (EO) provides a synoptic view and frequent coverage. With the launch of the Copernicus Sentinel satellites, operational water quality services become a business opportunity. CoastObs will develop a service platform for coastal water monitoring with validated products derived from EO. In dialogue with users from various sectors, CoastObs will develop innovative EO-based products: monitoring of seagrass and macro-algae, phytoplankton size classes, primary production, and harmful algae as well as higher level products such as indicators and integration with predictive models. CoastObs will establish sustainable supply chains that can be directly integrated into the users’ systems. The CoastObs consortium has the knowledge and ambition to develop services that are commercially viable, grow in capacity and thus create new jobs. The business case is to define user groups with common requirements, so tailored products can be developed at highly reduced costs per user. Setup of efficient data structures (array database) for smart (re)processing of data is part of this ambition. The commitment of 13 users to CoastObs demonstrates the need for such user-friendly and affordable coastal water services

Keywords: water quality,coastal areas,coastal zone management,aquaculture,environmental monitorin and reporting,marine engineering,ecological indicators,operational services
Bringing Quality of Service to Blockchain-Based Clouds (STARCloud)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-10
End date: 2021-06-09
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

Today the cloud market is restricted to few providers, which entails higher prices, vendor lock-in and lower service quality. Smart Contracts (SC) and blockchain could reshape this market since they lower costs and provide trust without resorting to intermediaries. This paradigm, named blockchain-based clouds, prevents vendor lock-in and has the potential to make market's barriers so low that anyone with idle or spare computational resources can offer cloud services. The STARCloud project systematically utilises formal methods for the static analysis and runtime control of the next generation clouds for creating support for Quality of Service (QoS). To this aim, since the state-of-the-art solutions cannot be used in this domain, this project provides novel approaches and tools, including consensus mechanisms, a domain specific language for QoS definitions and QoS formal analysis tools, and a framework for the matchmaking and negotiation of SCs. Supporting QoS will boost the adoption of decentralised clouds; thus reducing prices and environmental impact; and improving QoS, which make the cloud providers and consumers that use blockchain-based clouds more competitive, specially in Europe, where the most advanced commercial solutions are located. Moreover, these solutions will enable geographically sparse micro and traditional cloud providers to join the market, which will leverage cloud and edge computing in Europe. The project is timely and, besides involving collaborators from many of the best European research institutes, it is supervised by I. Brandic, one of the main cloud experts in the world and actively involves one of the main players in the market: iExec. Overall, the solutions proposed here will contribute to the disruptive blockchain-based cloud paradigm and find immediate use in industry and academia by addressing the fundamental requirement of most cloud consumers, in particular business: QoS definition and enforcement in completely distributed systems.

Keywords: quality of service,blockchain based systems,cloud computing,distributed systems,smart contracts
Enabling Smart Computations to study space RADiation effects (ESC2RAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,France,United Kingdom
Call: Space Weather (H2020-COMPET-2017, 2017)
Start date: 2018-05-01
End date: 2021-08-31
Duration (months): 40.0
Total project cost (EUR): 1262763.75
EU funding (EUR): 1262763.75
Participants: 5
Project status: CLOSED

This project aims at establishing a fundamental and applied research program via the set up of a new “virtual modeling lab” which will open the path towards a change of paradigm in the modelling of Space Weather impact. The project indeed aims at putting forward a next-generation of space radiation predictive tool, based on the combination of Space environment tools and high performance, parameter free (first-principles) approaches from the materials science/chemical-physics community, able to calculate with predictive power both the materials’ and the DNA damag In particular, by combining the SPENVIS tool with a highly efficient first-principles materials modelling tool (SIESTA), the new approach will be used to study the degradation of solar cells and the DNA damage for a LEO orbit and an interplanetary travel, under different worst-case Space Weather scenarios. On the basis of the new results, which can disentangle different microscopic effects contrary to the often overall response split out by particles transport tools, we will be able to redefine in detail the “worst case scenarios” in Space Weather, for each sub-parts of a solar cell and different DNA segments, with respect to current definitions. By applying data-mining/smart search algorithms we will be able to propose possible radiation-resistant materials and, on the basis of a new DNA damage descriptor, possible mitigating agents acting on specific parts of the DNA. A first-principles database of key quantities for the interaction of space radiation and materials/biological samples will be set up, to be used both for future, first-principles-only, studies or for current studies improving the input to Monte Carlo tools. The study will pose the basis to enable smart future architectures, based on high performance computing, to better understand the risks posed by Space Weather and to search, with predictive power, possible game-changing solutions to enhance the lifetime of space missions.

Keywords: space weather worst case scenarios,impact on solar cells,biological damage,generation of first principles data,mitigation strategies
Monitoring EU energy efficiency first principle and policy implementation (ODYSSEE-MURE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Spain,Ireland,Germany,Italy,Cyprus,Malta,Switzerland,Switzerland,Serbia,Finland,Poland,Belgium,Bulgaria,Hungary,Romania,Slovakia,Sweden,Norway,Greece,Croatia,Lithuania,Slovenia,Sweden,Latvia,France,France,Czechia,Netherlands,Luxembourg,Portugal,United Kingdom,Denmark
Call: Supporting public authorities to implement the Energy Union (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2021-11-30
Duration (months): 30.0
Total project cost (EUR): 1780358.09
EU funding (EUR): 1737592.46
Participants: 37
Project status: CLOSED

The ODYSSEE-MURE project aims to support policy makers in EU Member States to fulfill their obligations in the framework of the EU Energy Efficiency Directive (EED). In particular, it provides user-friendly databases and web-tools for monitoring and evaluating the impact of energy efficiency policies. The ODYSSEE database and facilities contain and analyse latest available energy consumption and energy efficiency indicators by sector, end-use in households and services, by mode in transport. The MURE database and facilities contain and analyse energy efficiency policies and measures by sector. These tools have been conceived in the past and will be extended under this project by an experienced team comprising national energy efficiency agencies from 28 EU Member States (plus Norway, Switzerland and Serbia), and a strong technical coordination. Future inclusion of Balkan countries will be prepared under this project. We enhance, update and modernise these tools for support to the Member States through regional and national training events as well as dissemination products such as country/sector profiles, newsletters, policy briefs and webinars. In addition, we focus on operationalising the Energy Efficiency First Principle (EE1-P) for the MS, which is a key requirement in the EU Energy Union Governance Regulation . We will develop an indicator-based approach to EE1, considering wider aspects such as (1) New Societal Trends (e.g. the Shared Economy) which may increase or reduce energy demand, (2) Energy poverty, (3) the multiple benefits of energy efficiency. We will disseminate the analysis developed in this project to national bodies, inter alia by dissmeinating the outputs at key conferences (such as the eceee conferences).

Keywords: policy evaluation,monitoring,energy consumption,experience sharing
Single Cell EPigenomic, Transcriptomic, and structural Rearrangement profiling to investigate Evolution in prostate cancer (SCEPTRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-10
End date: 2023-04-09
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Prostate cancer (PrCa) is the most frequently diagnosed cancer in men in the European Union (EU), and is a molecularly and clinically heterogeneous disease. Although the genomic and transcriptomic landscapes of PrCa have been characterized deeply, the genome-wide epigenetic landscape and its contribution to tumor heterogeneity has received less attention. The lack of single-cell methylation (with parallel single-cell transcriptomic) datasets in solid tumors (and none in PrCA) has stunted inference on clonal evolution. Consequently, the understanding of the coordinated relationship between methylation and transcriptome remains tenuous at best. Structural variants have also not been able to be accurately resolved in cancer due to the reliance on short-read sequencing, and their interplay with DNA methylation is still poorly understood. I present the project, SCEPTRE which is tightly connected to and builds upon ample expertise in the laboratories of Prof. Christoph Plass, Division Chair of Cancer Epigenomics, DKFZ, and Dr. Oliver Stegle, Division Chair of Computational Genomics, DKFZ. Within this project, I will drive the generation of novel ‘single-cell’ and ‘single-molecule long-read’ PrCa datasets, and exploit existing data resources to comprehensively assess the epigenetic and joint transcriptomic and genomic dimensions of human PrCa with the aim to examine cancer evolution. To realize this aim, I will also derive a comprehensive computational toolbox for the analysis of single-cell (and single-molecule) DNA methylation and joint multi-omic profiles. This project will deliver novel innovative ways to identify epigenetic drivers; as well as link DNA methylation for lineage tracing as a biomarker for disease progression. Moreover, the project will uncover putative relationships between the DNA methylome and transcriptome as well as between structural genetic aberrations and epigenetic changes.

Keywords: bioinformatics,single cell,nanopore,multi omics
HYPERNEX: IGNITION OF THE EUROPEAN HYPERLOOP ECOSYSTEM (HYPERNEX)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Coordination and support actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Italy,Spain,Spain,Norway,Greece,Poland,France,France,Netherlands,United Kingdom
Call: Innovation in guided transport (H2020-S2RJU-OC-2020, 2020)
Start date: 2020-12-01
End date: 2022-02-28
Duration (months): 15.0
Total project cost (EUR): 250000.0
EU funding (EUR): 250000.0
Participants: 13
Project status: CLOSED

HYPERNEX addresses the need for a catalyst to accelerate the development of the fifth mean of transport, hyperloop, in Europe. A convergence of R&D entities, industry players, regulators and society needs to be aligned with hyperloop developers. While regulators and standardization bodies need to understand the operation and specification of the new transport mode, the industry and R&D ecosystem need a better understanding on how they can provide value to enhance hyperloop technical development. Therefore, HYPERNEX will cover the ignition of this work, bringing the relevant information into a monolithic asset, creating a ground of understanding among hyperloop developers and providing also the inertia to make the movement sustainable and durable in the coming years.

Keywords: hyperloop,european transport network,roadmap,specifications