Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Facade of Industrial Internet (PGplant)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Industrial Internet of Things is expected to disrupt entire industries. The market related to IIoT is forecasted to add trillions of dollars to the global economy by 2030. This new and lucrative market opportunity attracts a variety of players, among them large established business system providers as well as innovative newcomers with emerging technologies. The current situation is that many large industrial organizations are stuck with current IT infrastructure and are therefore sluggish in implementing IIoT solutions. This situation is at the moment rapidly changing and will open an opportunity window for innovative SMEs, which create new services and disruptive practices in close cooperation with forward looking industrial partners. Process Genius Ltd (PG) is one of those newcomers changing the way industrial companies are managed. We offer a new approach to visualize corporate data and empower the decision making. We do it by providing customers with a revolutionary multi-layered 3D user interface, which replaces multiple UI's of current business systems. This so called Digital Twin technology has appeared in the latest Gartner’s Hype Cycle for the Internet of Things among Top 10 Strategic Technology Trends for 2017 with transformational impact on the industry. According to Gartner’s definition, Digital Twin is “a dynamic software model of a physical thing or system”. So PG’s approach brings additional value on top of the basic concept. We give to industrial internet an attractive 3D facade. PG’s main objective for the near future is to make our business scalable and ready for expansion to the global market. Since technically our solution is already well scalable, we should focus on the scalability of our business model as well as its validity outside the domestic market. Actions described in this proposal will provide proper grounds for expansion in EU market. The main industrial focus of Phase 1 and Phase 2 projects will be in manufacturing industry.

Keywords: industrial internet,digital twin,data visualization,virtual process model,business intelligence,decision making,digitalization,gamification
PT-symmetric electronic structure theory (PTEROSOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-11-30
Duration (months): 66.0
Total project cost (EUR): 1895636.0
EU funding (EUR): 1895636.0
Participants: 1
Project status: SIGNED

Processes related to electronically excited states are central in chemistry, physics, and biology, playing a key role in ubiquitous processes such as photochemistry, catalysis, and solar cell technology. However, defining an effective method that reliably provides accurate excited-state energies remains a major challenge in theoretical chemistry. In PTEROSOR, we aim at developing a totally novel approach to obtain excited-state energies and wave functions in molecular sys- tems thanks to the properties of non-Hermitian Hamiltonians. Our key idea is to perform an analytic continuation of conventional computational chemistry methods. Indeed, through the complex plane, ground and excited states can be naturally connected. In a non-Hermitian complex picture, the energy levels are sheets of a more complicated topological manifold called Riemann surface and they are smooth and continuous analytic continuation of one another. PTEROSOR’s main goal is to develop a new theoretical approach allowing to connect, through the complex plane, electronic states. Instead of Hermitian Hamiltonians, we propose to use a more general class of Hamiltonians which have the property of being PT-symmetric, i.e., invariant with respect to combined parity reflection P and time reversal T. This weaker condition ensures a real energy spectrum in unbroken PT-symmetric regions. PT-symmetric Hamiltonians can be seen as analytic continuation of conventional Hermitian Hamiltonians. Using PT-symmetric quantum theory, an Hermitian Hamiltonian can be analytically continued into the complex plane, becoming non-Hermitian in the process and exposing the fundamental topology of eigenstates. Our gateway between ground and excited states are provided by exceptional points which lie at the boundary between broken and unbroken PT-symmetric regions.
The first bioherbicide blocking germination of herbicide-resistant weeds (SteriWeed)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Weeds cause more than 35 Billion € annual global losses, equivalent to 34% of crop yield. If weeds were uncontrolled, about 50% of the crops would be lost. Therefore, synthetic (chemical) herbicides have been used since the late 1940s. However, herbicide’s use has resulted in weed’s evolution. Hence, the most persistent challenge of modern agriculture is the increasing incidence of weed resistance. Bioherbicides have been introduced as an efficient, yet environmentally-friendly alternative to synthetic herbicides. However, they perform inconsistently, have limited shelf-life, have potential adverse effects for humans and are not economically viable. Therefore, there is an urgent need to develop new technological methods of weed control and management that do not depend on synthetic herbicide use. We are developing SteriWeed, a novel biological herbicide based on treated pollen and designed to target the resistant-weed and not the crop. It is non-toxic, not chemical engineered, easy to apply and cost-effective. Our innovation lies in its simplicity as the SteriWeed production method consists of only two steps: natural pollen harvesting and irradiation. The results are inviable weeds, unable to produce seeds in the next season. Today, our team of 6 employees with interdisciplinary background have reached the proof of concept of our technology for A. palmeri, one of the most threaten weeds in the US, reaching outstanding weed control results. The goal of this project is to expand our technology towards the control of the main resistant weeds threatening the European crops. We estimate that in five years after launching the commercialization phase, SteriWeed will cover over 1.5 million ha across Europe, Israel and USA. We will reach €42 million in cumulative revenues (cumulative profit of €15.5 million – ROI 7.15). We estimate the payback time in beginning of 2023. We plan to hire 11 new professionals, technical experts as well as professionals in business.

Keywords: resisitant weeds,bioherbicides,weed management,food security,chemical free treatment,weed control
Development of Innovative Therapeutic Strategies for beta-hemoglobinopathies (DITSB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Beta-thalassemia and sickle cell disease (SCD) are caused by mutations affecting the synthesis or the structure of the adult hemoglobin (Hb) beta-chain. The only definitive cure is transplantation of allogeneic hematopoietic stem cells (HSCs) from an HLA-matched donor, an option available to <30% of the patients. The clinical severity of beta-hemoglobinopathies is alleviated by the co-inheritance of mutations causing expression of fetal gamma-globin in adult life - a condition termed hereditary persistence of fetal hemoglobin (HPFH). Transplantation of autologous, genetically modified HSCs is an attractive therapeutic option for patients lacking a suitable donor. To this aim, genome editing approaches based on the use of site-specific nucleases have been explored by many groups, including ours. These approaches may either revert the single point mutation causing SCD or reactivate fetal globin expression, by mimicking HPFH mutations or by decreasing the level of BCL11A, a master repressor of fetal Hb synthesis. Site-specific nucleases, however, generate double-strand breaks (DSBs) in the genome and raise safety concerns for clinical applications, particularly when used in DSB-sensitive HSCs. In this proposal, we aim at exploiting targeted base-editing to develop novel, efficacious and safe strategies for beta-hemoglobinopathies without generating DSBs. This will be attempted by (i) correcting the SCD-causing mutation, (ii) mimicking HPFH mutations in the gamma-globin promoters, or (iii) modulating the activity of a BCL11A erythroid-specific enhancer. These approaches will be tested in human adult erythroid cell lines and patient HSCs, differentiated in vitro and in vivo into mature red cells to evaluate editing efficiency, fetal Hb expression, phenotypic cell correction and biosafety. The ultimate goal of the project is to provide sufficient proof of efficacy and safety to enable the clinical development of base-edited HSCs for the therapy of beta-hemoglobinopathies.

Keywords: editing,crispr,cas9,beta hemoglobinopathies
Weighted Spintronic-Nano-Oscillator-based Neuromorphic Computing System Assisted by laser for Cognitive Computing (SpinAge)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Spain,Sweden,Portugal,Denmark
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4382118.75
EU funding (EUR): 4382118.75
Participants: 7
Project status: SIGNED

The brain is a highly complex, high performance and low energy computing system due to its massive parallelism and intertwined network, which outperforms the current computers by orders of magnitudes, especially for cognitive computing applications. A large effort has been made into understanding the computing and mimicking the brain into an artificial implementation, so-called neuromorphic computing that has received much attention thanks to the advances in novel nanoscale technologies. The current implementation of the neuromorphic computing systems (NCS) using Complementary Metal-Oxide-Semiconductor (CMOS) technologies has 5-6 orders of magnitude lower performance (operation/sec/Watt/cm3) compared to the brain. Spintronic devices, using the spin of the electron instead of its charge, have been considered one of the most promising approaches for implementing not only memories but also NCSs leading to a high density, high speed, and energy-efficiency. The main goal of SpinAge is to realize a novel NCS enabling large-scale development of brain-inspired devices outclassing the performance of current computing machines. This will be achieved by the novel structures using spintronics and memristors, on-chip laser technology, nano electronics and finally advanced integration of all these technologies. We expect this unprecedented combination of emerging technologies will lead to at least 4-5 orders of magnitude better performance than the state-of-the-art CMOS-based NCSs. The approach taken in SpinAge is to implement synaptic neurons using novel nanoscale weighted spin-based nano-oscillators, assisted by a low-energy laser pulse irradiation from an integrated plasmonic laser chip, integrated all with the CMOS interfacing electronics for a proof-of-concept of a 16x16 NCS for cognitive computing applications. Our breakthrough platform technology will demonstrate EU leadership of advanced neuromorphic computing.
Understanding mechanisms and functions of miRNA oscillations during development (miRhythm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-08-02
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Successful development of an organism relies on careful temporal orchestration of a large number of diverse events. Although processes such as cell proliferation, migration and differentiation are thus under precise temporal control, molecular mechanisms of the relevant biological timers have remained largely enigmatic. I propose to exploit the repetitive development and robust oscillatory gene expression of the nematode C. elegans to identify fundamental principles of temporal control of organismal development through rhythmic gene expression. High temporal reproducibility of developmental progression and genetic tractability are additional major assets of this novel experimental paradigm. Previous work in my host-lab uncovered high-amplitude oscillatory expression of ~2700 genes peaking exactly once per larval stage, with an ~8-hr period. These oscillations appear to orchestrate periodic developmental events encompassing synthesis and shedding of the cuticle, cell proliferation and differentiation. A small set of regulatory miRNAs also exhibit oscillations with large amplitudes. This is surprising given that miRNAs are generally quite stable, and that the transcript level oscillations appear to be rely mostly on rhythmic transcription. Here, I propose to delineate the function of oscillatory miRNAs in rhythmic gene expression and development, and the mechanisms that render them sufficiently unstable to facilitate oscillation. Thus, through a combination of high-throughput developmental tracking, single-cell sequencing, bioinformatics, and biophysics approaches, I expect to uncover molecular mechanisms that control developmental timing and miRNA metabolism.

Keywords: oscillation,developmental timing,c elegans,mirna
New Enhanced Acoustic Damping Composite Materials (NEODAMP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,United Kingdom
Call: New enhanced acoustic damping composite material (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 350012.5
EU funding (EUR): 350012.5
Participants: 2
Project status: CLOSED

NEODAMP is marked in the ITD Airframe part B, oriented to highly integrated innovative structural components, for the Large Passenger Aircraft. NEODAMP will develop new prepreg composite materials for structural purposes in the aircraft, able to support structural loads and other additional functions. The project is focused on acoustic damping and complemented with electrical conductivity studies while using techniques related to additional embedded and/or integrated functionality. Composite materials will be chosen among those provided by a widely experienced manufacturer, to meet the future needs and requirements given by the topic manager. Activities are distributed along 36 months, and tasks are associated to 3 main topics: material development, screening and process ability. In order to find the optimal material, a series of key characteristics will be selected, such as acoustic damping, structural and mechanical properties, HSE requirements, Fire, Smoke&Toxicity resistance for fuselage applications, resistance to environmental factors, automatic manufacturing and costs. The damping material will be improved and modified to adjusts properties such as tacking or curing parameters. All the cited features will be deeply studied through a test campaign, at coupon level using raw damping material and the embedded damping prepreg composite material. The wide variety of tests will include from damping behavior and vibro-acoustic performance to lightning strike protection, including aging, common mechanical properties and physicochemical tests. Needed panels and embedded design will be done and manufactured by the partners. Results of the cited works altogether will guide to the optimal design and manufacturing of trials, which will reach to material improvements also. The production of demonstrators will be oriented to automatic fuselage production by using automatic fiber placement techniques and always considering possible solutions for industrialization.

Keywords: damping,prepreg composite,vibro acoustic performance,structural load
Hybrid INDustrial CONstruction through a 3D printing “all-in-one” machine for large-scale advanced manufacturing and building processes (HINDCON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Greece,Romania,Norway,France,France,France,Denmark
Call: Novel hybrid approaches for additive and subtractive manufacturing machines (H2020-FOF-2016, 2016)
Start date: 2016-09-15
End date: 2019-09-14
Duration (months): 36.0
Total project cost (EUR): 4798205.0
EU funding (EUR): 4798205.0
Participants: 14
Project status: CLOSED

Advanced Manufacturing has been highlighted by the EU as one of the key enablers to support and promotion of business research and innovation in key enabling technologies. Therefore, a number of objectives, aligned with pursuing the large scale targets, have been set for advanced manufacturing through four pillars: technology, economic, social and environment. Thus, HINDCON project aims to adapt manufacturing technologies to the construction sector, advancing towards industrialisation and overcoming the limitations of actual approach for introducing Additive and Subtractive Manufacturing in construction activities. The project has a duration of 36 months. The main aim of the HINDCON project is to develop and demonstrate a hybrid machine regarding 3D printing technologies with concrete materials focused on the industrialization of the Construction Industry, delivering to this sector an innovative technology that reduces environmental impact at the same time it reduces dramatically economic costs. The collaborative structure of the project will help to: 1) Integrate different technologies that converge in a hybrid solution. HINDCON “all-in-one" machine will integrate Additive Manufacturing concrete extruder and Subtractive Manufacturing tool kit with the use of cementitious materials including mass materials with alternatives in concrete and additives, and reinforced with composites. 2) Cover the different aspects concerned (technology, economic, social and environment) and demonstrate the hybrid machine from different perspectives. On the one hand, it includes testing basic capabilities of the integrated prototype in laboratory. On the other hand, it involves the demonstration of the manufacturing system in a relevant environment.

Keywords: additive manufacturing,subtractive manufacturing,3d printing,hybrid machine,concrete materials,cable robot system,software,customization,sustainable manufacturing,construction,building
Novel Nanoengineered Optoelectronic Biointerfaces (NOVELNOBI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Türkiye
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Interfacing with neural tissues is an important scientific goal to understand cellular processes and to combat nervous-system related diseases. Nanotechnology has a significant potential for the development of new neural interfaces. The atomic-level design and control of the nanostructures for neural interfacing can revolutionize the junction between neurons and nanomaterials. In this project, we propose a totally new approach for understanding fundamental requirements and from this knowledge designing customised nanomaterials with optimised characteristics. These will be used to develop and demonstrate unconventional neural interfaces that are ultimately designed, controlled and constructed at the nanoscale. Hence, the key objectives of this proposal are: (1) to use quantum mechanics in a new way to control and explore the neural photostimulation mechanism, (2) to explore, design and synthesize new biocompatible colloidal nanocrystals for neural photostimulation, to overcome the limitations in terms of toxic material contents (e.g., cadmium, lead, mercury, etc.), (3) to demonstrate novel biocompatible neural interfaces with exciton and quantum funnels, and plasmonic nanostructures for enhanced spectral sensitivity and dynamic range. This new approach from quantum mechanical design to nanocrystal assembly will enable exploring, tuning and controlling the underlying physical mechanisms of neural photostimulation. Furthermore, the biocompatible nanomaterials will result in a more reliable nanobiojunction. The funnel and plasmon structures will lead to unprecedented spectral sensitivities and dynamic ranges that are far beyond the state-of-the-art optoelectronic interfaces. The project is therefore expected to have high impact and may herald a new paradigm in neural interfacing. NOVELNOBI is expected to attract significant attention of researchers from diverse fields such as photonics, nanomaterials, photomedicine and neuroscience.

Keywords: nanocrystal,photostimulation,neuron,energy transfer,exciton,plasmon