Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating the Conjectures of Fine-Grained Complexity (CONJEXITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2022-12-01
End date: 2028-05-31
Duration (months): 66.0
Total project cost (EUR): 1499250.0
EU funding (EUR): 1499250.0
Participants: 1
Project status: SIGNED

Fine-grained complexity theory identifies a small set of conjectures under which a large number of hardness results hold. The fast-growing list of such conditional hardness results already spans many diverse areas of computer science. Improved algorithms for some of the most central problems in these domains are deemed impossible unless one of the core conjectures turns out to be false, terminating decades-long quests for faster algorithms. Much research is going into closing the remaining gaps, addressing more domains, and achieving beyond-worst-case results. But should these conjectures, that are the foundation of this entire theory, really be treated as laws of nature? In addition to three primary conjectures, the community has put forth about ten others. These ``secondary conjectures'' are often stronger variants of the primary conjectures, stating that the core problems remain hard despite introducing new assumptions on the input; they let us prove more hardness results but are also less extensively studied (and less likely to be true) compared to the original conjectures. Stepping away from current research that is hustling towards achieving tight bounds for all important problems under such conjectures, this project aims to investigate the conjectures themselves. Our main objective is to resolve the secondary conjectures; either by falsifying them or by establishing their equivalence to a primary conjecture. Either of these two outcomes would be satisfying: Refuting a conjecture must involve disruptive algorithmic techniques, impacting numerous other problems. Unifying a secondary conjecture with an original (primary) conjecture reinforces the validity of the conjecture and all its implications, solidifying the very foundations of Fine-Grained Complexity. We believe that there is a pressing need for such an investigation of this rapidly growing theory.

Keywords: fine grained complexity,conditional lower bounds,reductions,graph algorithms
Development and trafficking of type 1 and type 17 mucosal-associated invariant T cells (MAIT-TraDe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites presented by MHC-related protein 1 (MR1) on thymocytes thereby acquiring an effector phenotype (type 1 or 17). This project aims at elucidating mechanisms that regulate the last stages of thymic MAIT cell development, including their egress, and identify cues necessary for tissue colonization. Specifically, we will couple transcriptomics and thymus transplantation models to analyze canonical thymic MAIT cell development, thereby identifying new regulators of the MAIT1/17 fates, as well as to identify MAIT cells that recently exited the thymus and seeded mucosal organs, thereby identifying new regulators of tissue adaptation. These targets will be functionally tested in models combining CRISPR/Cas9 encoded by lentivirus with bone-marrow chimeras or adoptive transfers. Additionally, we will determine the identity and dynamics of MAIT cells exiting the thymus to colonize tissues by combining different experimental approaches including in vivo EdU/biotin labeling, thymectomy and blockage of thymus egress. Lastly, we will address whether MR1–microbial metabolites are required for the maintenance of MAIT cells in tissues at steady-state using mono-colonization/decolonization of germ-free mice and by conditionally ablating Mr1. Overall, this work will uncover fundamental mechanisms underlying MAIT cell development and tissue colonization. Albeit outside the scope of this work, it is possible that the mechanisms uncovered here may have implications in other innate-like T cells or for the establishment of mainstream tissue-resident T cells.

Keywords: mucosal associated invariant t cells innate like t cells t cell development thymus mucosal immunology
Explorations in polar question meaning and its variation (EPOQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

This project addresses polar question meaning and its variation by documenting and analyzing nuanced polar question meanings and their expressions across languages. Under current models of polar question meaning, meaning nuances across languages are heavily undergenerated and certain effects such as negative polarity licensing and forms of bias remain elusive. We use the idea of the Duality of primary polar question meanings introduced in the applicant’s recent work as a departure point, which defends a separation between polar and other propositional alternatives. This view makes correct predictions in the treatment of existing problems and generates hypotheses as to the limits and structural correlates of variation. The project will generate a crosslinguistically viable semantic model of polar question meaning and a framework of its variation based on a sizeable empirical contribution detailing polar question usage profiles from a diverse set of languages, elicited with a state-of-the-art twin questionnaire. The project combines advanced insights and techniques from the semantics and pragmatics of questions, semantic variation, and linguistic documentation, and is particularly timely in the context of the applicant’s recent work. The applicant and the host possess crucial, complementary skills in addressing these issues. The applicant is an expert in syntax, intonation and linguistic variation. The entire host institute and in particular the supervisors are world-renowned for their work on semantics and pragmatics, with a strong focus on questions. Their collaboration will thus create a unique opportunity to thoroughly reanalyze a central topic from multiple theoretical and empirical angles while furnishing the applicant with skills in semantics, pragmatics and advanced empirical methods with which she intends to launch further crossmodular linguistic variation projects and position herself as a leader in this domain of research.

Keywords: polar questions,semantics,pragmatics,linguistic variation,negation,bias,alternatives,nuanced meanings
AI-Driven Rapid Condition Assessment for Masonry Arch Bridges (AIdaMArch)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Masonry Arch Bridge (MAB) still plays a critical role within railway and roadway networks in Europe and worldwide. MABs constitute the majority of the European bridge stock. These structures were mainly built following empirical rules and were not designed to resist current traffic loading. Furthermore, nowadays, MABs are confronting the challenges of climate change and severe environmental conditions that degrade their performance. An accurate assessment of these complex structural systems represents a crucial step to preventing future failures and preserving them for the next generations. AIdaMArch introduces a tailored structural health monitoring approach that leverages a two-step data-driven methodology based on Long Short Term Memory (LSTM) models. The LSTM model enhances structural health monitoring by rapidly analyzing large amounts of sequential sensor data for real-time, continuous and adaptive monitoring of structures. MAB sensor measurements are not able to be analyzed by data-driven methods due to a lack of proper training data. To simulate the structural behaviour, a novel numerical model will be developed, and the data set will be augmented by a cyclic generative adversarial network for a higher level of applicability. AIdaMArch possesses the versatility of using a two-step data-driven method to not only detect anomalies (damage detection) but also extend its application to identify the severity of damage in MABs by the small number of measurements. The main goal of this proposal is a continuous, rapid, and accurate methodology for the health monitoring of MABs. To ensure the successful implementation of the project, Dr Emadi will conduct research at the Imperial College of London, with the guidance of Prof. Macorini, a leading scholar in the field, as a main supervisor. This project will prepare Dr Emadi to become a tenured scholar and obtain advanced funding, strengthening his academic profile and allowing him to establish his own research group.

Keywords: masonry arch bridges,condition assessment,structural health monitoring,artificial intelligence,heritage conservation,
Terahertz HyperSpectral low-Cost fAst GrapheNe Camera (TeraScan)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2026-03-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

‘TeraScan’ aims to increase the technology readiness level of the state-of-the-art, ultrafast single layer graphene (SLG) detectors operating at terahertz (THz) frequencies, devised under the ERC consolidator grant ‘SPRINT’, and develop a hyperspectral imaging demonstrator suitable to the translation of this technology to industrial end-users. The focus is on providing a compact, hyperspectral (HS) SLG camera which is low-cost (<40k€), fast (individual pixel response time < 10 ns), with low power consumption (<20W) and scalable, operating at room temperature, with NEP < 100 pW/√Hz, (frequency independent) suitable for real-time detection, in particular at operating frequencies > 2.5 THz, far exceeding the performances of commercial THz cameras. Once integrated with multiwavelength high-power quantum cascade lasers, the resulting far-field hyperspectral imaging system is plan to exceed by orders of magnitude the cost reduction, speed and resolution performances of commercial time-domain spectroscopy systems. Specific objectives are to manufacture a compact, portable and user-friendly THz SLG camera, integrate it, on a portable optical bench, with THz QCLs, validate its core technology with commercial end-users and at trade-shows and evaluate opportunities by identifying novel end-user applications, with a detailed market, IPR and regulatory compliance study. By the end of this programme, I plan to identify a solid exploitation route by directly cooperating with THz instrument producers and with targeted commercial end-users. Endorsing a solid commercial exploitation route, TeraScan prospects new directions and long-term impacts, in a frontier frequency domain, on many interdisciplinary fields crossing engineering, biology, medicine, cultural heritage and quantum communications.
Intra-party politics in the past and the present (INTRAPOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1533887.0
EU funding (EUR): 1533887.0
Participants: 1
Project status: SIGNED

The INTRAPOL project aims to understand the processes that determine who get elected into positions of political power and whether who is in power is important for citizens’ welfare. A well-performing system is able to select competent and honest leaders who are representative of the citizens’, and who have incentives or the will to make decisions to the benefit of the people. We study these fundamental aspects of political selection in representative democracies from an intra-party perspective. We consider the party and its various actors as separate entities. We aim to understand the role of insiders in representative democracy by carrying out a thorough analysis of how political parties operate, connect to voters, organize their internal structure, and recruit their political personnel, and to study the policy effects of these choices. The first work package travels far to the past to the origins of the modern party system in Victorian England. We build a remarkable data set of real-life voting choice that is possible due to studying pre-secret-ballot era. This allows us to apply quasi-experimental designs study whether voters identify with parties or candidates. Are voters motivated by changes in their economic interests? How does the entry and exit of candidates affect the fortunes of the parties and voter flows between the candidates? What was the political geography of Victorian England? The second work package studies the internal organization of parties by analyzing the objectives and role of party leaders and internal conflicts within parties by developing and estimate structurally an equilibrium model of party organizations. We test our model using both quasi-experimental and survey experimental designs and data from modern UK and Finland. Third work package uses The Finnish Defense Forces draft data on cognitive competence and personality traits to analyze their role in political selection and its policy effects using quasi-experimental research designs.

Keywords: political geography,political psychology,political selection,quantitative analysis
Twinning with ISMA to develop innovative calorimeters for high energy physics based upon advanced scintillation materials (TWISMA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Ukraine,Switzerland,France
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1499545.0
EU funding (EUR): 1499545.0
Participants: 4
Project status: SIGNED

TWISMA’s overall aim is to boost the scientific excellence and innovation capacity of the Institute for Scintillation Materials (ISMA) and its high-quality Twinning partners - CERN and Institute of Light and Matter – to develop innovative calorimeters for high energy physics (HEP) based upon advanced scintillation materials. To achieve this aim, TWISMA will implement a research and innovation strategy over three years based upon five objectives implemented via five corresponding WPs. Objective 1: Conduct exploratory research on innovative calorimeters for HEP based upon advanced scintillation materials The objective is to develop a prototype homogeneous calorimeter based upon bismuth germinate-silicate oxides plus a prototype sampling calorimeter based upon Ce-doped garnet fibres. Both calorimeters for application in HEP. Objective 2: Transfer knowledge between experienced researchers (ERs) of ISMA and Twinning partners The objective is to organise short term staff exchanges, trainings and seminars for ISMA’s ER’s and the Twinning partners’ ERs to complement the preparatory research undertaken in Objective 1. Objective 3: Enhance career prospects of early-stage researchers (ESRs) of ISMA and Twinning partners The objective is to enhance the career prospects of ISMA’s ESRs and the Twinning partners’ ESRs by organising short- and medium-term exchanges, training workshops/seminars, summer schools, and a joint PhD programme. Objective 4: Improve ISMA’s management & administrative capacity for European R&D programmes The objective is to improve the skills of ISMA’s Planning Department in proposal preparation, project management and innovation management for European R&D funding programmes. Objective 5: Raise the research profile of ISMA & the Twinning partners The objective is to raise the research profile and scientific reputation of ISMA and the Twinning partners through a comprehensive range of dissemination, exploitation, communication and outreach activities.

Keywords: advanced scintillation materials,bismuth germanate silicate oxides,ce doped garnet fibres,homogeneous calorimeter,sampling calorimeter,high energy physics
2D-Pilot Line (2D-PL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Austria,Sweden,Spain,France,United Kingdom,Finland,Netherlands,Switzerland
Call: Pilot line(s) for 2D materials-based devices (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01-CNECT, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 32997565.75
EU funding (EUR): 32997565.75
Participants: 16
Project status: SIGNED

Building on the foundation of the 2D-Experimental Pilot line project (2D-EPL), the 2D-Pilot line project, 2D-PL, has the ambition to further strengthen the European ecosystem in the development of the relevant integration modules for offering prototyping services in the field of photonics and electronics, working on the maturation of the technology, and providing essential information aiding industrial uptake. The main objective of the pilot line is to further mature 2DM fabrication in an industrially relevant FAB environment to secure the 2D pilot line access. The service offerings include the preparation of relevant process design kits (PDKs) and multi-project wafer (MPW) run offerings, which are an essential part of this project's outreach plan. The large application space for 2DM and the broad differentiation for material property requirements make the development of such a pilot line very challenging. Therefore, within the scope of the 2D-PL project, the focus for module maturation is tailored towards the photonic and electronic devices and circuits reaching academic institutions, research centres, SMEs, and larger businesses.

Keywords: materials engineering,nano materials,integration,equipment development,materials development,pilot line service,pdk
Collaborative Action and Research for Engagement, Persistence and Adherence in Treatment & Health (CAREPATH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Sweden,Israel,Netherlands,Spain,Germany,Ireland,Poland,Belgium,Denmark,France,Italy,United States,Switzerland,United Kingdom
Call: Support healthcare system resilience through a focus on persistency in the treatment of chronic diseases (HORIZON-JU-IHI-2024-06-two-stage, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 19802965.0
EU funding (EUR): 11300000.0
Participants: 41
Project status: SIGNED

CAREPATH aims to improve chronic disease management and medication persistence by transforming the care ecosystem, ensuring personalised support for better health outcomes, and reducing healthcare costs. We focus on improving medication adherence and persistence for three prevalent chronic conditions: Obesity (BMI ≥ 30 kg/m2), Type 2 Diabetes Mellitus (T2DM), and cardiovascular diseases (CVD), including chronic heart failure (CHF), across six diverse European countries: Germany, Israel, the Netherlands, Poland, Spain, and Sweden. These countries represent various EU healthcare environments and economic statuses, emphasising the need for tailored approaches to patient care. Our strategy involves integrating localised non-digital and digital health solutions to address the unique healthcare delivery challenges in each region. The CAREPATH toolbox collects, combines, and customises existing solutions into adaptable modules for broad application in both primary and secondary care settings. This toolbox will be tested in four studies across two settings in all six countries in both primary and secondary care. Three pilot studies in different regions as well as a proof-of-concept study in Germany will be conducted. This comprehensive evaluation, including HTA, aims to assess the toolbox's implementation and effectiveness, with a strong focus on learning what works for what groups of patients in which setting. Recognizing the significant impact of obesity, particular emphasis is placed on treatment adherence and persistence of medications that facilitate weight loss, such as dual GIP/GLP-1 receptor agonists, but CAREPATH studies also include patients using lipid-lowering drugs, insulin, and SGLT2 inhibitors. Our goal is to empower patients by improving communication and data sharing among patients, healthcare providers, and other stakeholders, thereby supporting the entire ecosystem and alleviating the burden on healthcare systems.

Keywords: obesity,diabetes,cardiovascular diseases