Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Training in European Asset Health Management (TEAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,United Kingdom,Switzerland,Denmark,France,Austria
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 3249341.0
EU funding (EUR): 3249341.0
Participants: 7
Project status: CLOSED

Transport demand, both for passengers and freight, is growing strongly. To meet the economic growth targets of the Lisbon Agenda and to facilitate the economic integration of the European Union, European transportation needs to cater for a continuing medium term growth in demand. However, transport growth using the technologies of today is unsustainable. New technologies and processes need to be developed which deliver cheap transport which is sustainable. In the past two decades there has been a revolution in electronic sensor and processing technologies. Sensors and the associated multiplexing electronics and software tools are now cheap and reliable which creates potential for new innovative uses in all kinds of ways. The TEAM proposal will exploit the benefits of new sensor and processing technologies, methodologies, models and algorithms to monitor the condition and safety of transport infrastructure. These new sources of asset health data, combined with new computer models and algorithms, will achieve a step change gain in the accuracy of condition and safety assessments. Knowing exactly the processes, parameters, implications and state of health of transport infrastructure assets, will extend their safe working lives and reduce costs. It will prevent premature and sub-optimal repair, rehabilitation and replacement of assets without compromising safety. The TEAM project will not just achieve these technological advances but will also develop training structures for a new generation of PhD students with the specialist and complementary skills necessary to develop the transport infrastructure of tomorrow.

Keywords: technological sciences,road transport technology,bridge engineering,sensor technology,concrete engineering,road engineering,materials engineering
Sustainable Hydrogen Generation (SUSHGEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,France,Norway,Bulgaria,Greece,United Kingdom,Spain,Greece
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 1736940.0
EU funding (EUR): 1736940.0
Participants: 8
Project status: CLOSED

Water arguably is the only true renewable source of hydrogen fuel. However extraction of the hydrogen requires significant energy input; either thermal, electrical or light. By utilizing a renewable electrical energy source, water electrolysis offers a practical route to sustainable hydrogen production. The coupling of electrolysis with renewable electrical energy (e.g. from wind) enables the full available energy to be stored as fuel (hydrogen) when there is low electrical energy demand. In addition water electrolysis offers a convenient method of localised hydrogen supply which overcomes problems and issues of its distribution. The use of a proton exchange membrane (PEM) or solid polymer electrolyte (SPE) in water electrolysis enables hydrogen production from pure (demineralised) water and electricity. PEM water electrolysis systems offer advantages over traditional technologies; greater energy efficiency, higher production rates (per unit electrode area), and more compact design. A restricting aspect of water electrolysis is the relatively high cost of the electrical energy. This programme is targeted at reducing this electrical energy requirement and reducing electrolyser cost by researching new materials for electrodes and membranes in PEM electrolysers that function at higher temperatures; thereby reducing thermodynamic energy requirements and accelerating electrode kinetics. Thus the aim of this research is to form a collaborative training programme that focuses on hydrogen production from water using advanced, medium temperature proton exchange membrane electrolysers. By operating cells at higher temperatures the free energy of the cell reaction falls and thus lower standard potentials are required. In addition, moving to the higher temperatures can enable reduction in Pt catalyst use and/or use of non-Pt catalysts for electrodes. In these ways we can reduce the capital and operating costs of PEM hydrogen electrolysers. Although high temperature elec

Keywords: physical sciences,chemical engineering,energy technology,hydrogen production
Hybrid Models for Tailoring Nano-Architectures of polymers (NANOPOLY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Portugal,Czechia,Germany,Netherlands,Spain,Switzerland,Netherlands,Germany
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 2702706.0
EU funding (EUR): 2702706.0
Participants: 9
Project status: CLOSED

The large scale production of commodity polymers is increasingly shifting overseas. Europe still plays a major role in polymer processing and product development, but the competition with the US and Asia requires distinctive efforts to sustain this leadership. Thus, it is decisive for European researchers and companies to design innovative, specialised commodities and optimise current production strategies. NANOPOLY’s main scientific objective is to further create, exchange and spread-out such know-how systematically within a European network in order to make this progress available and exploitable for European industries and coming generations of researchers. NANOPOLY will be unique in combining the strengths of applied mathematics/software engineering on the one hand and macro-molecular chemistry/reaction engineering on the other hand. These two sets of competences are currently rather unrelated but represent an important source of innovation for creating new models and associated software tools that permit new rational designs of polymer materials. NANOPOLY’s main training objective is the education of a new generation of researchers who are able to bridge the still significant gap between the two mentioned sets of competences. The job market urgently calls for researchers with suchlike sophisticated knowledge and interdisciplinary training. These prospects will make participation in the network a rewarding career option. Through superior training, intense cooperation, and outreach the network will build-up an exeptional multi-disciplinary, European-based community that is able to achieve the crucial transfer of knowledge between the associated fields and thus permit major innovation in improving technological processes that allow tailoring nano-architectures of polymers to specific requirements.

Keywords: polymerisation process technology,stochastic-deterministic hybrid models,nano-architectures of polymers,polymeric materials,gelation,emulsion,morphology,monte-carlo,software engineering
Environmental Chemoinformatics (ECO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Netherlands,Germany,Netherlands,Sweden,Spain,Italy
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 3386676.0
EU funding (EUR): 3386676.0
Participants: 7
Project status: CLOSED

The implementation of the new EU legislation concerning the registration, evaluation, authorization and restriction of chemicals (REACH) requires demonstration of the safe manufacture of chemicals and their safe use throughout the supply chain. REACH encourages development of new in vitro test methods and replacement of animal tests wherever possible by alternative methods. These goals are not achievable without well-trained personnel with a broad expertise and knowledge in both experimental and computational areas of environmental sciences. The requirements for such scientists, however, are not limited to the REACH implementation itself. Large companies and SMEs could be interested to employ such specialists to perform risk assessment and prioritization of molecules in the development stage. Therefore, the primary objective of this ITN (http://www.eco-itn.eu) is to contribute to the education of a new generation of scientists, environmental chemoinformaticans, who will receive advanced training in both environmental and computational methods. To achieve this goal the ITN will train the fellows using expertise and knowledge of its partners in various complementary computational and experimental areas of environmental sciences. The additional training will also be offered by means of Winter and Summer Schools and will include both theoretical and practical courses. The internships to the laboratories of associated partners will allow fellows to learn new methods and to broaden their knowledge in the field. A flexible system of Short Term Fellowships will offer additional targeted training to researchers originally not associated with the network. Given the potentially great business impact of evaluating more than 120,000 industrial chemicals in the European market within the next decade, the fellows of this network may have a significant economic dimension with regard to the hazard evaluation of chemicals in Europe.

Keywords: environmental protection,environmental risk assessment,ecotoxicology,environmental risks,biodegradation,computational chemistry,qsar,qspr,modelling (environmental risks),chemoinformatics
SCALing by means of Ubiquitous Storage (SCALUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Spain,United Kingdom,Germany,Greece,Spain,France,France,Slovenia,Germany,Germany,United Kingdom
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 3298114.0
EU funding (EUR): 3298114.0
Participants: 12
Project status: CLOSED

Storage research increasingly gains importance based on the tremendous need for storage capacity and I/O performance. Over the past years, several trends have considerably changed the design of storage systems, starting from new storage media over the widespread use of storage area networks, up to grid and cloud storage concepts. Furthermore, to achieve cost efficiency, storage systems are increasingly assembled from commodity components. Thus, we are in the middle of an evolution towards a new storage architecture made of many decentralized commodity components with increased processing and communication capabilities, which requires the introduction of new concepts to benefit from the resulting architectural opportunities. The consortium of this Marie Curie Initial Training Network (MCITN) „SCALing by means of Ubiquitous Storage (SCALUS)“ aims at elevating education, research, and development inside this exciting area with a focus on cluster, grid, and cloud storage. The vision of this MCITN is to deliver the foundation for ubiquitous storage systems, which can be scaled in arbitrary directions (capacity, performance, distance, security) Providing ubiquitous storage will become a major demand for future IT systems and leadership in this area can have significant impact on European competitiveness in IT technology. To get this leadership, it is necessary to invest into storage education and research and to bridge the current gap between local storage, cluster storage, grid storage, and cloud storage. The consortium will proceed into the direction by building the first interdisciplinary teaching and research network on storage issues. It consists of top European institutes and companies in storage and cluster technology, building a demanding but rewarding interdisciplinary environment for young researchers.

Keywords: computer engineering,software technology,systems networks,storage systems
Geometric Phenomena in High-Dimensional Probability Distributions (GPHDPD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-01
End date: 2013-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project lies at the cross-roads of Convex Geometry, Probability Theory and the local theory of Banach spaces. We will study large classes probability distributions of geometric origin on spaces of a very high dimension, tending to infinity. A particular, important case is the uniform measure on an arbitrary high-dimensional convex body. Even though the latter class of probability distributions is quite diverse, we observe that some non-trivial principles persist. For instance, any uniform measure on a high-dimensional convex set necessarily has some approximately gaussian marginals. The recent years have seen progress in the analysis of such high-dimensional measures. The proposed project intends to deepen and extend these first signs of understanding, to contribute towards a comprehensive theory of convexity-related measures, and to develop new methods for the study of high-dimensional distributions in general.

Keywords: convex geometry,functional analysis,probability theory,high-dimensional phenomena
An Integrative Model for Nuclear Receptor Signaling: towards understanding of NR signaling in health and disease (NR INTEGRATIVE MODEL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-09-01
End date: 2011-08-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Nuclear receptors (NR) are transcription factors activated by nuclear hormones, dietary components and xenobiotics. Nucleo-cytoplasmic shuttling is an important part of NR signalling: NR nucleo-cytoplasmic shuttling is regulated by external NR ligands and different intra-cellular processes. In close collaboration with experimental groups within the Marie Curie RTN NucSys (Sept 2007-Sept 2009) we have build a mechanism based kinetic model, integrating nucleo-cytoplasmic shuttling and signalling processes. This model was created for one class of nuclear receptors, i.e., steroid hormone receptors, and is presently used for systems biological studies of the role of nucleo-cytoplasmic shuttling in steroid hormone receptor signalling. However, other groups of nuclear receptors have similar network structures. We here propose that the steroid hormone receptor signalling model can be used as canonical model and re-parameterised so as to become relevant for any of the most important nuclear receptor groups. In the project proposed in this application for a European Reintegration Grant, the canonical model of NR signalling will be adapted to several most important classes of nuclear receptors. Then, models of different nuclear receptor signalling pathways will be integrated in a bigger NR Signalling Integrative Model in order to begin to study the role of the entire network in health and disease. In particular, the research will be focused on the process of integration of different signals impinging the same NR signalling pathway and on crosstalk between different NRs. Taking into account the crucial role of both phenomena in the development of aging-related syndromes and many systems diseases such as cancer and osteoporosis, we anticipate substantial biomedical relevance of our study. In addition, our NR signaling integrative model may contribute significantly towards the “Digital Human”, i.e. the quantitative, molecules to human whole body model.

Keywords: natural sciences,systems biology,nuclear receptors,modelling,integration,cross-talk
Vascular niche and tumor microenvironment (VNTME-GAVARD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-06-01
End date: 2013-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cancer progression is a complex process where cells acquire aberrant proliferative, survival and migratory properties, as well as the ability to trigger the formation of a dedicated tumour blood supply. There is now compelling evidence that the bulk of the malignant cells in cancers contained a rare fraction of self-renewing, multi-potent, and tumour-initiating cells, termed stem-like cancer cells (SLCCs), that constitute a reservoir to generate and/or maintain the tumours. Such as developmental or normal stem cells, cancer stem cells reside within a stem cell niche, which heterogeneous composition always contains a vascular structure. Therefore, in addition to the delivery of nutrients and oxygen, and to provide a circulating option for metastatic cells, the tumour blood vessels may also form a specific and confined microenvironment where endothelial cells from the vascular wall and tumour stem cells from the tumour mass may interact. Indeed, these SLCCs reside in close proximity of tumour blood. In line with these recent observations and hypothesis, we propose to explore the nature of the interactions between “cancer” stem cells and brain endothelium, and how this niche may impact both stemness properties and endothelial barrier function. My research program involved 3 major aims: - Influence of the endothelium/cancer stem cell interactions on their transcriptome - Modulation of mTor signalling axis in the tumour vascular niche - Semaphorin signalling in the vascular niche Through the combination of innovative technologies and approaches, such as transcriptome analysis, cell imagery, in vivo model of angiogenesis, we have here a unique opportunity to better understand the basis for molecular and cellular interactions within the tumour microenvironment. Overall, I expect my proposal research to provide the molecular basis for the development of novel therapeutic targets designed to impede on deregulation of the vascular niche or to promote its normalization.

Keywords: stem cell,angiogenesis,adhesion,glioma,cancer
Effects of hypoxia and hypercapnia on thermoregulatory function (THERMOPHYSIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2010-02-01
End date: 2012-01-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Appropriate changes in skin blood flow and sweat rate are critical for humans to regulate internal temperature, especially during heat or cold stress. Limited previous research suggests that reductions in oxygen (hypoxia) and elevations in carbon dioxide (hypercapnia) concentrations affect skin blood flow and sweat rate. Up to now, however, the effects of hypoxia and hypercapnia on skin blood flow and sweating during heat or cold stress have not been thoroughly examined and are largely unknown. Research suggests that hypoxia and hypercapnia cause subtle elevations in skin blood flow and sweat rate but it is unknown if hypoxia or hypercapnia alters critical skin blood flow and/or sweat rate elevations during heat stress. Therefore, specific aims #1 and #2 of this project are to examine the effect of hypoxia and hypercapnia, respectively, on skin blood flow and sweat rate responses to whole body heating. Lower internal temperatures are evident during cold stress and hypercapnia or hypoxia, suggesting that hypoxia and hypercapnia could impair vital decreases in skin blood flow required to conserve heat during cold stress. Therefore, specific aim #3 of this project is to examine the effect of hypoxia and hypercapnia on the skin blood flow response to whole body cooling. These aims will be achieved using the latest and previously acquired research techniques, to gain further insight into thermoregulatory function by assessing skin blood flow/sweat rate and body temperature relationships during whole body heating and cooling under normal, hypoxic and hypercapnic conditions. This award will allow the effective reintegration of an ambitious researcher back into the EU by significantly improving their research environment, providing key foundations for career development and allowing the transfer of significant skills to the U.K and across Europe. Furthermore, the proposed work will enhance European scientific excellence and the world-wide recognition of European science.

Keywords: physiology,core temperature,skin blood flow,sweating,heating,cooling,oxygen,carbon dioxide