Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The innovative wastewater-based epidemiology approach with the advances of high resolution mass spectrometry as a complementary biomonitoring tool for assessing the health status of a population (NTS-EXPOSURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,Greece
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 248016.0
EU funding (EUR): 248016.0
Participants: 2
Project status: SIGNED

Humans are continuously exposed to toxicants by different routes, with potentially adverse effects on human health. Monitoring population exposure is a crucial part of public health programs and human biomonitoring (HBM) is the most widely used and powerful tool to evaluate the exposure of a population. These data are vital for health impact assessment and to support environmental and health policy-making in public health programs. However, novel approaches are needed in order to give additional information on exposure at population level and overcome the limitations of HBM studies. In this project, an innovative approach, called Wastewater-Based Epidemiology (WBE), is proposed as an alternative “biomonitoring tool” for the retrieval of epidemiological information from wastewater through the analysis of specific human urinary metabolites (biomarkers). Although WBE has been studied the last fifteen years, its application has been limited to target analytical methods and a few classes of compounds (i.e. illicit drugs). New methodologies such as the powerful high resolution mass spectrometry (HRMS) technique can opens new perspectives in the WBE field. The unique characteristics of HRMS combined with the potential of the WBE approach can give us the capability to provide valuable information for public health. Indeed, influent wastewater contains a wide range of chemical information about biological processes of the human body, which can be explored by the latest advances of HRMS and provide crucial data. The main objective is to develop non-target screening analytical methods based on HRMS coupled to liquid and gas chromatography that can detect new wastewater biomarkers and assess the collective consumption or exposure to toxicants. This project can establish and implement an integrated chemical analytical-epidemiological approach for the acquirement of crucial information and inform authorities and public health organizations on community health status.
Market Uptake Support for Intermediate Bioenergy Carriers (MUSIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Italy,Germany,Italy,Germany,Belgium,Belgium,Greece,Greece,Greece,Finland,Sweden,Netherlands,Netherlands,Netherlands
Call: Market Uptake support (H2020-LC-SC3-2019-RES-IA-CSA, 2019)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 2999871.25
EU funding (EUR): 2999871.25
Participants: 17
Project status: SIGNED

Intermediate bioenergy carriers (IBC) are formed when biomass is processed to energetically denser, storable and transportable intermediary products analogous to coal, oil and gaseous fossil energy carriers. IBCs can be used directly for heat or power generation or further refined to final bioenergy or bio-based products. MUSIC aims to facilitate further market uptake of three types of IBC (pyrolysis oil, torrefied biomass and microbial oil) by developing feedstock mobilisation strategies, improving logistics and development of IBC trade centres. First an evaluation is made of framework conditions to identify barriers and enablers. This will constitute the basis for core project actions i.e. development of (a) regional feedstock mobilisation strategies (b) tools for mobilising biomass and optimising size and location of trade centres, (c) industry-driven advanced and strategic case studies (one each per region; eight in total) yielding (d) optimised, cost-effective solutions for logistics along the entire IBC value chain. Two dedicated work packages targeting (i) regional stakeholders and (ii) industrial market actors, from the primary sector, industry and beyond, will build platforms for regional discourse and industry dialogue in the four target regions (Greece, Italy, Sweden/Finland and International). Project results are to include – besides direct market uptake due to the case studies, practical guidance to market actors and advice to policy makers serving as input for more informed policy, market support and financial frameworks, . The MUSIC consortium is characterised by strong industrial involvement, broad coverage across Europe, and top-level experience developing logistics for IBC. It comprises Europe’s leading technology developers for the three IBC types targeted. MUSIC consortium partners have wide networks in industry and industry platforms, ensuring relevance and transferability of all results.

Keywords: pyrolysis,torrefaction,microbial oil
Innovative modelling approaches for predicting Socio-environMentAl evolution in highly anthRopized coasTal LAGOONs (SMARTLAGOON)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Sweden,Norway,Switzerland,Denmark
Call: Environmental Intelligence (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3981907.5
EU funding (EUR): 3972313.71
Participants: 8
Project status: SIGNED

Coastal lagoons are ecosystems with great environmental and socioeconomic value. However, these natural systems are especially vulnerable to climatic and anthropogenic pressures, such as intensive agriculture and extensive urbanization as a consequence of the tourist development. Despite the vulnerability and complexity of these ecosystems, there has been limited development of novel techniques which can provide real-time monitoring, analysis and management of these critical resources. Beyond being useful for policy-making procedures at multiple levels of granularity, these tools can increase local and citizen awareness of environmental impacts. SMARTLAGOON project intends to develop a digital twin to build a systemic understanding of the socio-environmental inter-relationships affecting costal lagoons and their ecosystem. It will digitally replicate the policy-making procedure of these complex socio-environmental systems by combining, analyzing and interpreting data from different sources; including efficient in-situ IoT infrastructures with edge computing capabilities that reduce the overall system’s carbon footprint, remote sensing technologies, social media sensing, open-data repositories and data from human behavior, economics and the social sciences, by making recourse to advanced AI, NLP, physically-based and citizen science models. As a case study, SMARTLAGOON focuses on the Europe’s largest salt water coastal lagoon, i.e., Mar Menor (Murcia, Spain), which has suffered serious environmental degradation due to several socio/environmental reasons. We will jointly develop our tool with citizens, stakeholders and policy-makers of this area to address their needs and requirements, following an agile methodology to ensure practical and useful results for this particular scenario in the first instance and extend to other coastal lagoons in the second instance.

Keywords: artificial intelligence,forecasting,edge computing,crowdsensing,citizen science
Transcriptional RegulAtory Network controlling Strawberry Fruit Ripening and Quality (TRANSFR-Q)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2021-11-30
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Ripening is the critical step for the development of flavour quality in fruit. This character has significantly declined in many fleshy fruits over recent decades, primarily due to the focus of current breeding programs on agronomic traits such as production, firmness, and postharvest shelf life. This strategy has caused a tunnelling effect on genetic variability in many crops. This is particularly significant in strawberry, where current cultivars are derived from a narrow germplasm stock. A notable feature of strawberry fruit is that undergoes a non-climacteric ripening program independent of the hormone ethylene, in contrast to well studied climacteric fruits such as tomato, where ethylene plays a central role. Therefore, improving fruit flavour in present strawberry varieties requires two important breakthroughs: 1) a precise understanding of non-climacteric fruit ripening regulation that will allow the targeting of relevant quality genes, and 2) the identification of unexploited allelic variants from wild germplasm to be introgressed through the generation of novel breeding lines. The first objective will be achieved by (i) focusing on the sequenced, diploid Fragaria vesca, a wild relative of the cultivated strawberry that will serve as a model, (ii) identifying key transcription factors (TFs) regulating fruit ripening by generating a stage- and tissue-specific gene expression map, (iii) using a candidate gene approach and reverse genetics based on gene silencing and TILLING to verify the role of these TFs, and (iv) defining the gene regulatory networks controlling the ripening process via integration of transcriptomic, metabolomic and ChIP-Seq data obtained from the stably silenced and/or TILLED lines. Finally, TRANSFR-Q plans to use this knowledge, combined with the identification of novel alleles from a core collection of Fragaria germplasm, to transfer flavour quality characters into current strawberry cultivars.

Keywords: plant,strawberry,fragaria vesca,fruit ripening,fruit quality,transcription factor,gene regulatory network,rna seq,chip seq,metabolomics,tilling,natural variation
gender CLImate Migration: innOvatiVe European Union socio-legal avenues (CLIMOVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2023-03-31
Duration (months): 12.0
Total project cost (EUR): 85736.64
EU funding (EUR): 85736.64
Participants: 1
Project status: CLOSED

The overall aim of this fellowship is to provide a comprehensive and innovative socio-legal analysis of climate change-induced migration in the EU from a gender perspective. The migration policies and laws existing within the EU and its member States ignore the climate change and gender as causes of migration flows, although the EU is among the world's top three CO2 emitters after China and the United States, responsible of climate change induced migration. Ignoring such dimensions, gender and climate, impede first to protect those who are the most vulnerable, in particular women and girls as migrants; second, to prevent social conflicts, discrimination and human rights violations within the EU; and third to consider the beneficial labor and economic effect of female migration for host societies. Responding to this legal and policy gap, this multi-disciplinary project aims to accomplish the following two objectives: 1) to develop a comparative analysis on the comprehensive legal framework of the EU member states on migration, climate change and gender, including the identification of good practices and regulatory improvements and 2) to exploring all the possible regulatory improvements at EU level and at the domestic level to cope with the insufficient commitment and protection of EU towards climate migration from a gender perspective. To accomplish these objective, the applicant will obtained advanced training in methodological and doctrinal training in migration and climate studies, using an innovative feminist methodology, contributing to acquire new skills to problematize the deficiencies and to propose new EU legal avenues. The project’s scientific importance, operationalised through its 5 work packages and associated scholarly impact and dissemination activities, lies in its original contribution as the first multi-disciplinary study to propose these new socio-legal avenues at EU level, necessary to properly recognize and protect climate gendered migration.

Keywords: gender climate migration,migration crisis,climate change emergency,climate migration,eu migration policy,eu socio legal avenues
A coordinated framework for cyber resilient supply chain systems over complex ICT infrastructures (FISHY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Italy,Switzerland,Greece,Greece,Slovenia,Portugal,Portugal,Portugal
Call: Building blocks for resilience in evolving ICT systems (H2020-SU-ICT-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 4999400.0
EU funding (EUR): 4999400.0
Participants: 17
Project status: SIGNED

Project FISHY aims at designing, developing, validating and demonstrating a coordinated framework for cyber resilience provisioning to guarantee a trusted supply chain of ICT systems, built upon distributed, dynamic, and often fundamentally insecure and heterogeneous ICT infrastructures. We propose to design a novel FISHY platform able to securely orchestrate a supply chain consisting of complex ICT systems end-to-end, - from the IoT ecosystem and the edge and cloud infrastructure over to the networking infrastructure connecting -, and enabling functionalities related to risks and vulnerabilities management, accountability and mitigation strategies as well as security metrics and evidence-based security assurance. Conceptually, FISHY platform uses intent-based interfaces to orchestrate both existing and beyond state-of-the-art security appliances in composed ICT scenarios leveraging capabilities of programmable network and IT infrastructure through a coordinated management. FISHY implements new strategies to leveraging data analytics, distributed ledger technology, intent-based security service orchestration, artificial intelligence and programmable network infrastructure. The platform is envisioned not only to facilitating adaptive system reconfigurations, but also reacting to and defying the effects of cyber attacks in real time of the ICT supply chain end-to-end, and in particular in the IoT domain. Finally, the FISHY proposes a comprehensive validation and demonstration strategy built upon three use cases from different sectors, including agriculture, manufacturing and transportation. The expected project outcome is a Proof-of-Concept (PoC) of the FISHY platform, along with the dissemination and ambitious exploitation strategies.

Keywords: cyber resilience,trusted supply chains,edge computing,privacy,risk management,evidence based security assurance,network security orchestration,vulnerability forecast
A novel rapid environmental test for the human pathogen Legionella (Bio-LP-1)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Ireland
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-04-01
End date: 2022-07-31
Duration (months): 28.0
Total project cost (EUR): 2826040.0
EU funding (EUR): 1978228.0
Participants: 4
Project status: CLOSED

Traditional microbiological culture for Legionella bacteria takes up to 14 days to provide a result. While some rapid methodologies have been developed they require 2-3 tests to be completed meaning it can take 3 days for a result and they also require capital investments in costly specialised equipment. Bio-LP-1 is a novel rapid test which has the capacity to transform the environmental global testing landscape for the human pathogen Legionella. Bio-LP-1’s unique selling point is that it provides a complete identification of Legionella to the serogroup level in a single test using molecular technologies. This is a diagnostic breakthrough, as all existing competitors can only offer 2 or 3 stage molecular tests to generate the equivalent result. The single test Bio-LP-1 product format is 5 x FASTER than the nearest competitor, Offers €319,200 pa savings for large test laboratories conducting at least 50,000 tests per year. Bio-LP-1 – offers a faster time to result; yields more robust information; requires less hands on time; requires no specialised equipment and ultimately has the potential for significant cost savings. Current estimates predict that the global legionella testing market will reach $352.6 million by 2025 and that the water testing market is the fastest growing sector. We have a best in class consortium: BPD - European experts in development and commercialisation of rapid microbial diagnostic solutions. myPOLs - leader in molecular biology reagent manufacturing. Genaxxon - European leader in sales of innovative molecular IVD products) Control Microbiológico - ENAC accredited large environmental testing laboratory.) BPD and myPOLS have previously collaborated in the development of Bio-Lp-1, over past 12 months to bring Bio-LP-1 to TRL 6

Keywords: human pathogen legionella environmental testing
Evolution of the honey bee gut microbiome through bacterial diversification (MicroBeeOme)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1499462.0
EU funding (EUR): 1499462.0
Participants: 1
Project status: CLOSED

Animals harbor specialized bacterial communities in their guts, typically referred to as gut microbiomes. Despite the importance of gut microbiomes for host health, surprisingly little is known about their evolution. There is evidence that the complexity of the mammalian gut microbiome has emerged through the diversification of a few founder lineages. However, how lineages have diversified into discrete species and which underlying mechanisms maintain the diversity in the gut remains elusive. The current project will address these questions by studying the gut microbiome of honey bees. We have recently found that the eight dominant bacterial lineages in the honey bee gut have substantially diversified, which is a striking parallelism to the evolution of the mammalian gut microbiome. Moreover, we have established experiments to colonize microbiota-free bees with cultured isolates of divergent bee gut bacteria. This provides us with unique opportunities to study bacterial evolution in the gut in a simple and experimentally amenable system. The project is divided into four work packages addressing interconnected research questions of current biology: We will (i) determine the population genomic landscape of divergent gut bacteria, (ii) investigate whether bacterial diversification has resulted in competition or cooperation, (iii) discover novel mechanisms of bacterial interactions, and (iv) reveal how bacterial diversification impacts the symbiosis with the host. To this end, we will use a multidisciplinary approach combining comparative metagenomics, transcriptomics, metabolomics, bee colonization experiments, microscopy, bacterial genetics, and automated bee tracking. This project situated at the forefront of microbial symbiosis will provide groundbreaking insights into microbial evolution and ecology, gut microbiology, and honey bee health and biology.

Keywords: microbial symbiosis,microbial diversity,gut microbiota,metagenomics,honey bee
Nonlinear Optomechanics for Verification, Utility and Sensing (NOVUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-07-30
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: SIGNED

Quantum optomechanical systems (QOMSs) are comprised of light that interacts with a small mechanical element. Their relatively high mass compared with other quantum systems and excellent sensitivity to small displacements makes them an ideal candidate for quantum sensing and tests of fundamental physics. Yet, due to the lack of analytical solutions for their nonlinear evolution, which is challenging to treat both analytically and numerically, many aspects of nonlinear QOMSs remain unexplored. The goal of this research project entitled Nonlinear Optomechanics for Utility, Verification and Sensing (NOVUS) is to develop theoretical tools for modelling nonlinear QOMSs, which will pave the way for a number of application-oriented and fundamental studies that have thus far been unavailable. Most importantly, it will bridge the gap between theory and experiments at a time when nonlinear features are becoming increasingly accessible in the laboratory. This key focus on foundations as well as experimental applications has been reflected in the choice of host group and secondments. Using the developed tools, I will consider some of the most promising applications of QOMSs, including gravity sensing, tests of the overlap between quantum physics and gravity, as well as fundamental questions for mesoscopic quantum systems. Precision metrology of gravitational fields have a number of fundamental and technological applications, including gravitational-wave astronomy and small-mass sensing, as well as improved earthquake detection arrays and geological surveys. Regarding low-energy tests of quantum gravity, the prospect of detecting gravity-mediated entanglement or noise signatures of quantised gravitational fields has the potential to shed light on some of the most fundamental questions in physics. The developed tools will allow me to carefully analyse the required experimental conditions, from which I can propose novel protocols and identify the optimal parameter regimes.

Keywords: quantum optomechanics,nonlinear optomechanics,gravity sensing,tests of fundamental physics