Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lassie: The first-ever painless breath analyser for people with diabetes, a breakthrough in blood glucose monitoring (Lassie)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-08-01
End date: 2025-12-31
Duration (months): 41.0
Total project cost (EUR): 8710500.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Today, dogs are used to detect high and low blood glucose, cancers and are tested for coronavirus. The new Lassie breath analyser BOYDSense will put the power of a dog’s nose into people’s hands and give them access to gentle health monitoring. Lassie starts with diabetes as it is an immense burden for 40 million people in Europe. Current glucose monitoring technologies are underused because they are highly invasive, expensive, stigmatising and generate a lot of waste. Lassie will transform this situation by making measurements painless, simple, discreet and cost-effective without any consumables. By analysing Volatile Organic Compounds (VOCs) in the breath, Lassie will calculate blood glucose value within current accuracy standard. As a result, Lassie users will test earlier in the disease and more frequently, leading to better diabetes management and significant cost savings. EIC Accelerator will put BOYDSense on track to become a global leader in non-invasive diabetes monitoring.

Keywords: diabetes,non invasive monitoring,breath,vocs,volatile organic comppunds,biomarkers,glucose monitoring,sensor,chronic disease,digital health
Mapping and Conceptualizing a Legal Framework for Maternal Rights during Pregnancy, Birth, and Early Motherhood (MaMas) (MaMas)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499955.0
EU funding (EUR): 1499955.0
Participants: 1
Project status: SIGNED

Many mothers in Western Europe experience some distress during the times of pregnancy, birth and postpartum, a period called “matrescence”. Although health, social and welfare laws offer some protection and accommodation to women during matrescence, the approach is fragmented and incomplete. The law has yet to address issues such as early pregnancy loss, obstetric violence, and the “motherhood penalty” at work. These experiences have been under-explored and under-theorised in law and feminist legal theory, despite their implications for the rights to health, non-discrimination, dignity, autonomy, work and equality. The lack of a holistic approach to maternal rights during matrescence represents a major problem for women’s rights and gender equity in Europe. The overall aim of MaMas is to develop a first legal framework of maternal rights during matrescence, anchored in women’s embodied experiences of matrescence, and to re-imagine rights from their vantage point. Using legal comparative methods and socio-legal methods, MaMas maps and analyzes health, labor, and welfare laws at national, regional and international levels to uncover which rights women have during this transition. Through qualitative methods, it investigates women’s experiences of matrescence, including their experience of rights. Based on the legal and qualitative analyses, the project identifies gaps in the current legal approach, develops new legal language and concepts to translate women’s experiences into law, and explores risks of essentialization. MaMas breaks new theoretical ground by constructing a legal theory of maternal rights during matrescence. Using a gender embodiment lens, it explores for the first time new pathways for the recognition of women’s rights during matrescence. This includes the development of new legal concepts and language, such as inter-dependency rights, right to time, respectful corporal rights, and the interrogation of the legal status of unpaid childcare work.

Keywords: rights pregnancy birth postpartum motherhood health law labor law,welfare law feminist legal theory gender embodiment
Neural markers of social brain activation in human-robot interaction (NeuroMarkerHRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2026-04-30
Duration (months): 35.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

With the imminent introduction of artificial agents into our digital future, robots will become teammates, companions and counterparts. However, it remains unclear whether people would interact with humanoid robots as social partners or use them as mere tools. NeuroMarkerHRI seeks to identify neural markers of the activation of social cognitive mechanisms with robots based on hemodynamic responses using supervised ML models. This will determine whether the human brain interprets the behavior from a humanoid robot using social (e.g., mirror neuron system, theory of mind) or general domain cognitive mechanisms (e.g., attention, cognitive control). With a hypothesis-driven and stepwise approach, the project will measure hemodynamic responses with functional near-infrared spectroscopy (fNIRS) in brain regions associated with social cognition, theory of mind and perception of mental states during collaborative interactions with humanoid robots. Hemodynamic signal features will be included in the machine learning models to identify predictors of social or general domain cognitive mechanisms. The project's interdisciplinary nature integrates well-documented methods of cognitive neuroscience, advancements in robotics, and state-of-the-art machine learning techniques to thoroughly evaluate the factors that modulate the activation of the social brain exposed to humanoid robots. Outcomes will set standards for future research in human-robot interaction, offer a reliable tool for designers to measure the effect of robot behavior on the users, and boost the development and improvement of efficient human-robot collaboration. The current project contributes to creating a human-centered development of technology and would help towards the digital transition in Europe, allowing to unlock the potential of social, industrial, and commercial human-robot collaboration.

Keywords: social cognition in human robot interaction,neuroimaging and computational neuroscience
Mechanisms of dormancy, activation and sexual conversion in pre-erythrocytic malaria parasites (DEXES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Malaria remains a devastating public health burden – the estimated death toll in 2020 was over 600,000. Its eradication is a desirable goal; however, the development of novel intervention strategies is hampered by limited current understanding of the biology of Plasmodium, the causative agent of malaria, and of its complex interactions with mammalian and mosquito hosts. In the liver, inside hepatocytes, Plasmodium parasites can either 1) replicate, forming new parasites that will infect erythrocytes and cause disease, or 2) remain dormant, which can lead to chronic, relapsing disease weeks to years after the original infection. I recently discovered new hepatic outcomes using a novel pipeline for single-cell hepatocyte-pathogen sequencing. I have identified sub-populations of sexually committed parasite forms, previously thought to appear only during erythrocytic infection. This groundbreaking insight into the Plasmodium life cycle can change our understanding of malaria transmission, yet it remains unknown how malaria parasites commit to these different developmental outcomes in hepatocytes. DEXES will test the hypothesis that Plasmodium liver infection outcomes depend upon the metabolic state of the host hepatocyte. Using engineered human microlivers, new humanized mouse models, trans-species studies and single-cell technologies, I will: 1) identify parasite-encoded molecular mechanisms implicated in the induction and maintenance of dormancy, activation, and sexual conversion in the liver, and 2) establish the bidirectional relationships between host metabolism and distinct parasite cell fates and their impact on treatment outcomes. This project will uncover the molecular mechanisms underpinning dormancy, relapsing and transmission of malaria parasites, and lay the groundwork for the future development of new therapies targeting the liver infection reservoirs.

Keywords: malaria,plasmodium,plasmodium vivax,hypnozoites,dormancy,relapse,sexual commitment,transmission,single cell,transcriptomics,host parasite interactions,metabolism,liver,hepatocytes,gametocytes
Neuro-encoded electronic skin (NEUCODES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-18
End date: 2026-12-17
Duration (months): 39.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 3
Project status: SIGNED

Electronic skin (e-skin) is a fast-emerging soft system to provide tactile sensations like our own skin. However, most of the prototypes today focus on the integration of various sensors on flexible substrates, which can hardly be integrated neurologically onto biological systems nor used over a large area as sensing components for robots: this is mainly because of their mismatch in various aspects including mechanical softness, computing/encoding capability, power consumption. This proposal aims to bring a step-change by developing an e-skin truly rooted in biological systems: the proposed e-Skin will respond to external stimuli (e.g., force) and encode the sensory information in the form of action potentials, just as the biological systems (i.e., sensory neurons) do. This will be achieved by innovative fabrication of neuron circuit arrays over a large area using nanomaterials, and further interfaced with tactile sensors, all on the soft substrate. Such “bio-like” localised processing, offered by the soft system, greatly decreases the latency of the sensory data, necessary for the upscaling of the sensing pixels to achieve human-level tactile sensation. Furthermore, this paves the way for the interfacing between soft electronics and biology, triggering transformations in the next generation of neurorobotics, neuroprosthesis and interactive systems.

Keywords: electronic skin,flexible electronics,neuromorphic hardware,tactile sensing,robotics,nanowires,
MOF and COF hybrid ultrathin films: A surface templated and scanning probe nanolithography approach (SURF-2DHYB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-03-08
End date: 2026-03-07
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Single organic molecules can be joined together to form extended frameworks. Materials that use metal-ligand coordination or direct covalent bonding as the ‘glue’ between organic subunits, termed metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), respectively, are being developed for a huge variety of applications. Hybrid materials, containing two, or in some cases more, distinct types of MOF and COF often have an observed enhancement in their properties compared with the constituent pristine MOF and COF materials. Thin films of MOFs and COFs have emerged as promising materials for incorporation into electronic devices, such as transistors and detectors. It could be envisaged that in a similar manner to the bulk materials, hybrid thin films containing multiple distinct types of MOF and COF could provide a route to improving the performance of already promising MOF and COF thin films. Instead of layering the different materials on top of one another (z-direction), here it is proposed that mixing the materials in the plane of growth (x/y plane) would enable the increase in the number of constituent MOFs and/or COFs without increasing the film thickness. The proposed project aims to pioneer methodologies to prepare such hybrid ultrathin films. In the first instance, scanning probe nanolithography will underpin the approach. Regions with diameters of up to 100 nm will be etched into surface mounted MOF or COF ultrathin films, followed by the formation of distinct COF and/or MOF types within these confined spaces. When the hybrid films have been thoroughly characterized by scanning probe microscopy and the processes by which they assemble have been established, a more scalable synthetic strategy to fabricate the materials will be developed. An approach which employs covalent surface functionalisation as opposed to scanning probe nanolithography to direct the selective incorporation of the different constituent materials will be taken.

Keywords: scanning tunneling microscopy,scanning probe nanolithography,metal organic framework,covalent organic framework
A quantum approach to symbolic dynamics (SDQI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

This project in pure mathematics aims to solve problems in symbolic dynamics (a mature branch of dynamics with important connections to coding theory, information theory, and operator algebras) using tools from the modern theories of quantum information and quantum groups. The central challenge dating back to at least the 1970s is to classify symbolic dynamical systems. My proposal pioneers a highly interdisciplinary and novel approach using the uniquely quantum phenomena of ‘entanglement’ and ‘noncommutativity’ as they appear in quantum information/quantum groups. The main objective is therefore to establish a fruitful connection between symbolic dynamics, quantum information theory and quantum groups to the benefit of all three communities. The proposal is based around two central open problems: how do we classify symbolic systems, and what are the symmetries of symbolic systems? A novel approach to these problems builds on the recent advances made in part by the supervisor that connect graph theory with quantum information/quantum groups. I introduce a new nonlocal game (the Conjugacy Game) that will define ‘quantum conjugacies’, and a notion of quantum automorphism that will define ‘quantum symmetries’ of symbolic systems. This marks the first interaction between quantum information/quantum groups and symbolic dynamics. The ideas are therefore very timely, will have high impact, and set a precedent for future uses of quantum mathematics in other domains and specifically other classes of dynamics (e.g. multidimensional subshifts and algebraic actions). The fellowship will strengthen my academic career via the opportunity to learn new tools in quantum mathematics and apply them to solve important problems in dynamics. It will also allow me to establish new collaborations with leading experts in dynamics and quantum information/quantum groups that will play a key role in my goal of obtaining a permanent academic job and an investigator grant to build a research g

Keywords: symbolic dynamics,quantum information theory,quantum groups,operator algebras
Carbon-neutral pathways of recycling marine plastic waste (CUPOLA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: China,Poland,Malaysia,Hong Kong,United Kingdom,Ireland
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 257600.0
EU funding (EUR): 257600.0
Participants: 18
Project status: SIGNED

Plastic pollution in the ocean causes severe damage to marine life and raises growing global environmental concerns. The harm to marine life and pollution to the ecosystem is devastating our oceans and is causing negative connections to human health. According to EU Legislation Research, an estimated 9 to 23 million tonnes of plastic enter the oceans every year, and the associated cost is between €485 million and €1,259 million. The recent Covid-19 pandemic has led to a significant increase in demand for single-use plastic, aggravating the long-lasting marine waste problem with an estimated 1.56 billion face masks have entered oceans in 2020 and even more in 2021. This project aims to develop sustainable, scalable, and profitable waste management processes for marine plastics. The automated plastic waste management and product innovation processes aim for environmental sustainability. Extensive training and knowledge exchange activities will be carried out among the world-leading scientist group through a total of 160 person-months of structured staff exchanges between 15 research institutes. The scientists in this group share the common objective to develop the CUPOLA processes for marine plastic waste recycling. Thermal and thermochemical conversion technologies will be applied to produce high-value marketable products. Full process modelling, techno-economic and life cycle analysis will be carried out to provide vital information about the feasibility of the novel process. CUPOLA will create a multi-disciplinary consortium consisting of process engineers, chemists, environmental scientists, and process modellers, and develop the innovative and economic waste-to-product process, closing the gap in the circular economy. It will produce multiple avenues for career development, cross-sectorial experience, and academic training in a multi-cultural, interdisciplinary and intersectoral environment, and lead to achieving SDGs 3, 12 and 14.

Keywords: marine plastic litter,chemical recycling
Detection of Chronic Toxicity of Xenobiotes using PANDORA-seq of small non-conding RNAs (XENOSEQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

The XENOSEQ project aims to develop tools for detecting epigenetic changes caused by chronic toxicity of chemicals by sequencing small non-coding RNA (sncRNA) profiles. Xenobiotics, including herbicides like glyphosate, have raised concerns regarding their possible effects on human and environmental health, but chronic and especially transgenerational effects are often ignored due to limitations of time and resources. This research project seeks to study whether the newly developed PANDORA-seq unveils subtle changes in sncRNA profiles that may serve as early indicators of chronic toxicity. PANDORA-seq utilizes two RNA modifying enzymes, T4 polynucleotide kinase and AlkB demethylase, to extend the repertoire of detected sncRNAs to an unprecedented world. Comprehensive sequencing of sncRNA profiles may reveal chronic toxicity associated with xenobiotic exposure. Here, we aim to 1) characterize baseline sncRNA profiles in healthy systems, offering a reference point for comparison; 2) expose biological systems to potentially toxic agents and track changes in sncRNA expression using PANDORA-seq; and 3) detect early indicators of chronic toxicity, allowing the development of a complementary tool for the assessment of chemical toxicity. PANDORA-seq's precision and sensitivity make it a promising tool for studying epigenetic regulation, which may cause chronic and transgenerational diseases. As this MSCA project is a first effort to use sncRNA for chronic ecotoxicology, we open the research field by using the fruit fly as a model organism, but the technique can be easily adapted for studying other relevant organisms, such as honey bees and mammals.

Keywords: sncrna profile,pandora seq,chronic toxicity