Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Observational Signatures of planet formation in externally IRradiated dIScs (OSIRIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 4
Project status: CLOSED

Star and planet formation typically occurs in star forming regions more massive than the nearby, low-mass regions that have been the main focus of observational studies of protoplanetary discs. In massive regions, irradiation by neighbouring massive stars can heat this protoplanetary disc of dust and gas, from which planets form. This heating drives thermal winds that extract dust and gas, reducing the mass available for planet formation. In typical star and planet forming environments, these winds are sufficient to drastically change the outcome of planet formation. However, this consideration is currently missing from models. Further, we are yet to find observational evidence of planet formation in the strongly externally irradiated discs that are the most common. These advances are essential steps in understanding the properties of exoplanets, and in uncovering the key processes that govern their formation. During this project, I will make new calculations of the mass-loss rates for irradiated discs as small dust grains are processed into planets. I will then use semi-analytic computational modelling to investigate how the process of planet formation differs in externally irradiated environments compared to non-irradiated environments. I will compare these models to state of the art observations of protoplanetary discs, putting constraints on the physics of disc evolution. Finally, I will run hydrodynamic and radiative transfer calculations to make predictions for observational searches for planets in irradiated environments. These efforts are essential for understanding how planet formation proceeds in typical star formation environments. In this way, I will unveil how the star formation environment sculpts the observed exoplanet population.

Keywords: planet formation,star forming regions,external photoevaporation,exoplanets
Dynamic system strategies for climate social tipping points (DARETOTIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: SIGNED

Society is currently struggling to manage a complex set of socio-ecological challenges related to climate change. Solutions range from reducing our consumption to novel technology used to decouple the economy from its impacts. Regardless of the strategy, materialising the green transition into a low carbon society means crossing a social tipping point (STP). An STP occurs when the collective action of a population reaches leads to wide-ranging systemic change. STPs can be triggered by bottom-up approaches like consumer boycotts, or top-down interventions like policies, tax disincentives, and trade agreements. The problem is that, so far, STP have only been described qualitatively and the mechanisms beyond their emergence remain poorly understood. The overall project goal is to provide a deeper understanding of which types of change allow society to move towards a more sustainable status, specifically by unveiling the role of social tipping points in reaching sustainability. I intend to use system dynamics (SD) to study social tipping points quantitatively. SD is a modelling approach to simulate feedback loops between variables in a system. SD is a perfect fit to the quantitative study of STPs for two reasons. First, it is a flexible tool to model coupled human and natural systems (CHANS), whereby ecological processes exhibit changes over time under the influence of human drivers. Second, it allows one to determine when changes in elements of the system lead to the crossing of a tipping point and to a different system configuration. My combined expertise in CHANS and SD, supported by my supervisor’s background in sustainability assessment make us an ideal team to conduct this research. Not only that, this fellowship will improve my research profile providing a steppingstone towards my career goals.

Keywords: system dynamics,sustainability,climate change,life cycle assessment
Clinical validation of a novel non-opioid analgesic derived from the Portuguese sea for treating chronic pain (Sea4Market)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 3570051.25
EU funding (EUR): 2499035.8
Participants: 1
Project status: SIGNED

Sea4Us is a world-class biotechnology company with a focus on translating marine-derived compounds with therapeutic potential for unmet medical needs into pharmaceutical assets. Sea4Us has developed a platform focused on drug discovery and development of novel pharmaceuticals based on its core expertise in ion channels and marine biology. Sea4Us is particularly focussed on developing and commercialising therapies for chronic pain. Sea4Us has developed a ground-breaking therapeutic drug to treat chronic pain in patients. Chronic pain affects 100 million people across Europe, 1.6bn globally, and has a devastating impact on quality of life. Pain is the most common reason people visit their doctors and a leading cause of disability. It is a source of enormous social and economic burden, costing Europe alone over 500 billion Euros a year. There are many medications on the market for treating chronic pain, but they are either ineffective for most types of chronic pain and/or have adverse side-effects. Opioid drugs are the most effective treatment but also inflict drug addiction, habituation and other noxious side-effects. Our novel analgesic molecule, Sea4Pain, has a novel mechanism of action meaning it is highly effective at treating chronic pain and without any known side effects unlike current drugs on the market. Sea4Pain is a first-in-class drug and has the potential to ease the suffering of billions of people globally. This EIC Accelerator project, called Sea4Market, will enable us to clinically validate our novel analgesic through completion of First-in-Human trials and out-license our technology to make a rapid entry into the multi-billion Euro Chronic Pain market. EIC support is essential to deliver this high-risk, high reward project and will enable the sustainable growth of our business. We will re-invest revenues from our licencing deal back into our project pipeline to solve other unmet medical needs and ensure the sustainable growth of our company.

Keywords: drugs,marine biology,pharmaceutical deals,licensing agreement drug development,preclinical development,pain treatment,non opioid analgesic,marine biotechnology,marine derived compounds
HYBRID BIOMETHANE PRODUCTION FROM INTEGRATED BIOMASS CONVERSION (HYFUELUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Portugal,Germany,Switzerland,United Kingdom,Greece,Spain
Call: Innovative biomethane production as an energy carrier and a fuel (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 11573443.92
EU funding (EUR): 10294334.44
Participants: 11
Project status: SIGNED

The ongoing decarbonisation of the energy and transport systems is a current challenge in Europe. As the rising prices of fossil natural gas make evident, the need to increase renewable gas capacity is undeniable and goes hand in hand with solving bottlenecks that current biomethane production technologies cannot effectively address. The HYFUELUP project aims to demonstrate a flexible and hybrid pathway for the efficient and cost-effective production of biomethane through thermochemical technologies combined with renewable hydrogen. A complete deployment value chain, including biomethane offtake and distribution, will also be demonstrated to contribute to the market penetration of biomethane in key sectors. Thanks to the broad composition of the consortium, the project will blend market knowledge with advanced academic and industrial perspectives to demonstrate the production of biomethane at scale. First, the flexible conversion of low-grade feedstocks via sorption-enhanced gasification will be validated, coupled with syngas or flue gas clean-up, in a demonstrator at TRL6. Then, a second demonstrator will also validate fluidised-bed methanation of either syngas or flue gas with the dynamic addition of hydrogen at TRL6, before both technologies are integrated into a third demonstrator to produce biomethane at scale and reach TRL7. Together, such developments work toward reaching the impacts of the work programme and lead to relevant changes in action and practice via two well-defined impact pathways (“technological development and adoption”, and “enhancing capacity”) that will ultimately help strengthen the European scientific leadership for the development of a highly competitive renewable gas industry, widen the technology portfolio of biomethane production technologies, and improve citizen well-being via reduced climate and social risks.

Keywords: biomethane seg oxy seg digestate low value feedstock fb methanation
Anode-Free Li-ion Batteries (AF-LIBs): Investigating Electrochemical Performance and Scalability for Next-Generation Energy Storage (AF-LIBs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Anode-free lithium batteries (AF-LIBs) have emerged as a promising alternative to conventional lithium-metal batteries due to their potential for higher energy densities, improved safety, and simplified manufacturing processes. However, their rapid development is hindered by poor charge/discharge cycles. This is due to the side reactions of the conventional battery electrolytes to form dead/inactive lithium, thereby leading to dendritic Li plating. I propose to investigate the use of High Concentrated Electrolytes (HCEs) and Multi-salt Electrolytes (MSEs) as novel approaches to achieve a robust and efficient plating and stripping of Li in AF-LIBs. The high concentration and/or presence of additives in these proposed electrolytes can regulate the thermodynamics and kinetics of the Li deposition/striping process, thereby overcoming dendritic Li growth. To achieve this objective, I will prepare novel HCEs, and MSEs and use various in-situ and operando structural and spectroscopic techniques to gain insights into the effects of the electrolyte types (different types of anion and cation) and composition on the lithium deposition and formation of SEI in AF-LIBs. These fundamental insights will facilitate the development of AF-LIBs, which are among the next-generation advanced energy storage technologies that are pivotal to the realization of energy and environmental sustainability.

Keywords: anode free batteries interphase engineering high concentrated electrolytes electrolyte additives artificial interphase engineering lithiophilic host
Capturing the potential of Gene editing for a sustainable BioEconomy (GeneBEcon)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Sweden,Cyprus,Latvia,France,Belgium,Denmark,Slovakia,Netherlands,Germany,Portugal,Switzerland
Call: New genomic techniques (NGT): understanding benefits and risks – focus on bio-based innovation (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 5032777.02
EU funding (EUR): 5032777.0
Participants: 19
Project status: SIGNED

New genomic techniques (NGTs) can contribute to an energy-efficient, low-input and zero-pollution agricultural production and industrial processing. Despite rapid recent progress, this toolbox is still in its infancy and substantial investments are needed to optimise the methods. Also, the innovation potential is fully exploited only if economic, social, and regulatory drivers coalesce and are accompanied by transparent communication and inclusive stakeholder engagement. A problem facing NGT innovation in Europe is that regulatory uncertainty restricts investment at all levels – research, innovation and scaling up – and the impacts of NGTs, both positive and negative, are not fully assessed. It also remains to be seen if public and stakeholder acceptance of NGT products will enable their application. The consequence is that NGTs do not yet reach their full potential. The research in GeneBEcon has two facets. First, the technical potential is explored by applying gene editing to develop 1) a virus-resistant potato with an industrial tuber starch quality, and 2) microalgae-based production of industrially relevant mycosporin-like amino acids. Second, the risk-regulatory aspects, economic incentives, and social perceptions are investigated. In the latter, comparative analyses are enabled by our approach with two different production systems: open-field agricultural crop and contained-system microalgae. The results will enable technical innovations as well as allow stakeholders (incl researchers, breeders, primary producers, value chain actors, risk assessors and decision makers) to take informed decisions on the safe and responsible use of NGT-derived products. GeneBEcon has a multi-sectoral consortium and the project links to relevant stakeholders through a Stakeholder Advisory Board. This will, through communication and inclusive engagement, enable an improved understanding and awareness of the risks and benefits of NGT-derived products through societal dialogue.

Keywords: gene editing,potato,microalgae,bioeconomy,innovation,risks,benefits,perceptions,systems approach
Monsoon Asia as the Nexus for the Transfer of Tantra along the Maritime routes (MANTRATANTRAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1972125.0
EU funding (EUR): 1972125.0
Participants: 1
Project status: SIGNED

Tantra dominated the Hindu and Buddhist socio-religious landscape across much of southeastern Asia from ca. the 7th to the 13th century. Once perceived ambivalently by scholars, and often still misrepresented in global pop culture as a form of sexual practice, the study of Tantra has now become a burgeoning academic subfield. However, the impact of Tantra on the religio-cultural history of Asia is still underappreciated, and disciplinary limitations as well as the Area Studies paradigm, fragmenting Asia into discrete areas, hamper our global understanding of this translocal phenomenon. Transcending these boundaries, the project will study Tantra from the perspective of cultural contact between different communities across the geo-environmental region referred to as ‘Monsoon Asia’, approaching the phenomenon in a global manner and in terms of ‘connected histories’ rather than in isolation according to distinct regional contexts. Taking the ‘medieval’ as its chronological framework, it will investigate textual corpora in Sanskrit, vernacular, and non-Indo-Aryan languages that have seldom been studied in a comparative manner, and complement the textual data with art historical evidence. In so doing, it will frame the emergence, transfer, and transformation of Tantra as a mobile and multi-centric network of people, languages, and objects that circulated across a vast interconnected region sharing common geo-environmental factors (e.g., the periodical monsoon winds). Besides uncovering the interactions between elite and nonelite socio-cultural milieus in the constitution of tantric traditions, it will also transcend the asymmetrical framing of premodern cultural relations between South Asia and the remainder of the wider Indic world, and highlight the shared religious heritage in a vast region that hosted the majority of the world population both historically and in the present, which has been artificially fragmented by national and global geopolitical configurations.

Keywords: tantra,tantrism,shaivism,hinduism,buddhism,south asia,southeast asia,east asia,monsoon asia,maritime silk roads
Spectroscopy and Geochemistry of chert. Reconstructing human mobility in the Pyrenees from the first Modern Humans to the last Pleistocene hunter-gatherers (SPEGEOCHERT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

In Palaeolithic archaeology, steep mountain ranges have been perceived as geographical barriers, impeding human mobility from the territories that flank them on both sides. This is the case of the Pyrenean mountain chain, a key area for studying mobility and territoriality of prehistoric hunter-gatherers, especially during the last glaciation (c. 120.000 – 11.000 BP), due to its geographic location and harsh environmental conditions. The Pyrenees were until recently considered by archaeologists as a complete hindrance to human mobility and the only possibility, it was thought, was through the less abrupt extremes. However, in my earlier work I was able to suggest that humans may have crossed over the mountains by several alternative itineraries, proposing that the classic view is most probably wrong. These works were based on a new approach to the analysis of prehistoric chert tools using geochemical methods and it is in this context that the SPEGEOCHERT project aims to investigate. The project will innovatively employ an array of interdisciplinary methods to explore the possible routeways humans followed through the Pyrenees to overcome the rough milieu. This pioneering approach will be based on portable, low-cost, non-destructive, fast and accurate techniques consisting on the use of reflectance spectroscopy combined with geochemistry and the application of multi-variate statistics and GIS to develop predictive modelling. Through the analysis of large series of materials directly at the museums, the SPEGEOCHERT project will create a novel data corpus with accurate information related to the geological chert sources exploited by Palaeolithic groups. The results obtained in this project will not only significantly broaden our knowledge on human adaptations to harsh ecological conditions and the understanding of mobility through mountains, but will also radically change the archaeological approach to the analysis of lithic raw materials.

Keywords: chert procurement,human mobility in mountain environments,upper palaeolithic
SyntAIr - IMPROVED ATM AUTOMATION AND SIMULATION THROUGH AI-BASED UNIVERSAL MODELS FOR SYNTHETIC DATA GENERATION (SynthAIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Norway,Italy,Belgium,Netherlands
Call: Fundamental Science and Outreach for Artificial Intelligence (AI) for Aviation (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 1215003.75
EU funding (EUR): 993550.0
Participants: 4
Project status: SIGNED

The main objective of SynthAIR is to explore and define AI-based methods for synthetic data generation in the domain of ATM system due to the limitation of AI-based tools development by the lack of enough data available (e.g., safety-related data) and the problem of generalization of those AI-based models. We want to explore data-driven methods for synthetic data generation, since they require 1) less user knowledge expertise (no need to derive the explicit model of the distribution), 2) better generalization capabilities. More in detail, inspired by recent advancement in Computer vision and Language Technology, we propose the concept of Universal Time Series Generator (UTG). A UTG, is a model trained on several different time series, and able to generate a synthetic dataset representing a new dataset, simply conditioned by a compressed representation of it. In aviation domain, this generator can be trained on a certain set of data related, for example to few airports, and be used to generate synthetic data from a new airport. The same principle can be applied to define a universal time series forecaster (UTF) able to do prediction to a new environment (I.e., data from a new airport) without any new training.

Keywords: aritificial intelligence synthetic data generation