Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoscale self-assembled epitaxial nucleation controlled by interference lithography (NanoStencil)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Finland,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2021-07-31
Duration (months): 46.0
Total project cost (EUR): 3208740.0
EU funding (EUR): 3208740.0
Participants: 6
Project status: CLOSED

By overcoming all the limitations of conventional top-down nanostructuring, the NanoStencil project seeks to initiate a new process paradigm for the production of dense arrays of identical nanostructures of precise size, shape and composition. It achieves this by combining the simplicity of structuring with light, with the advantages of molecular self-assembly, to provide a single step, cost effective and state of the art capability for next-generation ordered arrays of nanostructures. New methods to achieve such structures are a vital requirement for the exploitation of devices in the quantum regime. In our approach, laser interference patterning is applied by means of ultrashort pulses to material surfaces at the nanostructure formation phase, where it acts to modify local reaction processes providing energetically favourable sites for the nucleation of self-assembly. The approach is based on some established principles and prior art gained within the consortium, but is yet to be demonstrated at the device scale. To achieve in-situ nanostructuring, precision laser interference optics and state of the art pulsed lasers are integrated within materials reactors producing concentrated light patterns with a pitch of fractions of the laser wavelength which then induce local photothermal or photochemical modifications on the growing surface, creating sites for self-assembly. The science objectives of the project are to develop a comprehensive understanding of the absorption of concentrated pulsed light at the nanoscale to understand how this impacts on a growing or reactive surface. The technological objectives are to demonstrate large scale highly ordered arrays of identical nanostructures within four diverse materials systems (InAs quantum dot arrays, patterned SiO2/metallic nanostructures, ZnO nanowires and functional metal oxide nanospots), each of potentially transformative impact within the themes of semiconductor electronic and photonics, sensing and biomaterials.

Keywords: nanomaterials,nanotechnology,lithography,optics,lasers,semiconductors,epitaxy,deposition,processing,quantum dots,nanowires,biomaterials,functionalisation,quantum technology
High precision and scalable indoor positioning system (GT POSITION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Denmark
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Danish SME GamesOnTrack will target a major market opportunity through the development of an innovative high precision indoor positioning system (GT POSITION). The GT POSITION system will address the current market need for indoor positioning systems with high precision and scalability, being of particular interest for the indoor robotics and tracking systems industries. The GT POSITION system is capable of indoor positioning of static and mobile objects with extremely high precision – 10 mm. Also, GT POSITION has high scalability i.e. the location of thousands of objects in a vast area could be determined at same time, without losing the high precision capacity. By ensuring and demonstrating a maximum level of precision, scalability and simplicity at an affordable price, we will attain a key differentiating factors in order to gain access to the market. Initially, this will require a Phase 1 feasibility study that will give us a clear direction for our demonstration and market replication strategies. Later, based on proven feasibility, in the Innovation Project (Phase 2) we will need to generate full-scale showcases, which demonstrate the technical and economic benefits of our solution, to generate enough consumer confidence and facilitate broader market uptake. If objectives for Phases 1 and 2 are successfully achieved, we will be favourably positioned towards a very large opportunity for GamesOnTrack. Accordingly, we foresee a cumulative revenue of more than €18.5 million, 5 years after commercialization of the novel GT POSITION system.

Keywords: indoor positioning,high precision,scalability,robotics,indoor drones,tracking systems
Development of an electrochemical multiSEnsor platform for the simultaneous detection of emerging bREast caNcer biomArkers in a blood droplet (SERENA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood. Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy. My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies. An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine. This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications. Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions. The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI.

Keywords: artificial nucleic acids,biosensors,point of care device,printing technology
EGNOS-GPS/GALILEO-based high-resolution terrestrial-aerial sensing system. (mapKITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Spain,Switzerland,Brazil,Portugal,Portugal
Call: Small and Medium Enterprise (SME) based EGNSS applications (H2020-Galileo-2014-1, 2014)
Start date: 2015-03-01
End date: 2017-04-30
Duration (months): 26.0
Total project cost (EUR): 1530268.75
EU funding (EUR): 872191.26
Participants: 10
Project status: CLOSED

The first objective is to build a mature prototype of a novel tandem terrestrial-aerial mapping system based on a terrestrial vehicle (TV) and on an unmanned aircraft (UA), both equipped with remote sensing payloads. The UA will follow the TV at a constant flying height above ground while geodata are acquired simultaneously from the TV and the UA. The final product is high resolution, oriented, calibrated and integrated images of a corridor and its environment. The second objective is to demonstrate services; i.e., the technical/commercial feasibility of the concept. The third objective is to develop the market: at the end of the project, contracts or negotiations shall be in place so the prototype can be used in operational conditions. MapKITE targets corridor mapping. It is a terrestrial-aerial surveying system that combines the advantages of the terrestrial and airborne (manned or unmanned) ones. It responds to corridor mapping market needs only fulfilled by much more expensive separate terrestrial and aerial missions. An enabling component is the navigation payload based on EGNOS and the E5 AltBOC Galileo signal, superior to existing/planned GPS signals and of particular interest for robustness/integrity. An octocopter of UAVision will be modified and equipped with the avoidance collision system of CATUAV. Due to the low weight of the UA (less than 5 kg), to its low flying altitude (range between 30 m and maximum allowed height) and to its inbuilt line of sight [TV to UA] keeping feature, mapKITE does not suffer from the regulations affecting UAS civilian use. Its design is dominated by safety and abidance to current and foreseeable rules for small UA. Unrestricted testing will be conducted in a segregated airspace area that has been recently awarded by the Spanish aviation authorities. MapKITE is highly innovative: new surveying paradigms, new mathematical models, new ways of fusing sensors and a new “map” product. It is protected by the Spanish patent 2012312

Keywords: novel product,egnos,galileo e5 altboc,terrestrial and aerial surveying,corridor mapping,rpas,robust navigation
Bogomolov Multiplier (BogomolovMultiplier)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This project is dedicated to studying a geometric invariant called the Bogomolov multiplier. The main objectives of the proposed project are threefold. First of all, we wish to understand how the structure of the Bogomolov multiplier depends on the structure of the underlying group. To this end, we set to inspect the behavior of the Bogomolov multiplier with respect to another group theoretical invariant, the coclass. In turn, this will require thoroughly developing a theory of Bogomolov multipliers associated to profinite groups. A particular instance of these are $p$-adic Lie groups. We aim to enrich our understanding of their Bogomolov multipliers by translating the study to their associated Lie algebras. Secondly, we are interested in applications of our knowledge about the Bogomolov multiplier. Our focus here will be to strengthen the visible connections between the Bogomolov multiplier and automorphism groups. Kang and Kunyavskii recently noted a link between the Bogomolov multiplier and the Tate-Shafarevich set. This relation is expressible in terms of outer automorphisms of a given group. We aim to prove the implication that groups possessing special outer automorphisms must have nontrivial Bogomolov multipliers. Further evidence of this interplay between automorphisms and Bogomolov multipliers can be seen in the category of representations of a given group as shown by Davydov, and we intend to look into these more abstract aspects as well. Lastly, we propose to explore some extensions of the Bogomolov multiplier to higher dimensions. Our intentions here are to find algebraic descriptions of higher dimensional unramified cohomology groups and of Ekedahl invariants akin to the combinatorial description of the Bogomolov multiplier. Peyre has shown that this can be achieved for unramified cohomology groups of degree three for a special class of groups. We see a possible extension of these results in terms of higher dimensional combinatorial objects.

Keywords: bogomolov multiplier,rationality problem,coclass,p adic lie group,rigidity,outer automorphism,automorphism of monoidal category,unramified cohomology,ekedahl invariants
Innovative machine for surface finishing of wire-drawn products (SURFWIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current hard wire rod applications are rising, demanding a higher mechanical strength, perfect straightening and improved surface finishing quality. Current machinery for improving rod surface finishing is a combination on several machines in series (straightening +grinding+ cutting+ tumbling) that work on soft wire (9-110 daN/mm2) thus do not reach demanding product requirements (160-220 daN/mm², surface finishing -Ra 0.2). Additionally, mentioned machines in series have a high energy consumption (186kW), high pollution & waste (oil, gas and water), limited safety, and high operation & maintenance (O&M) cost as they need a high number of operators. To overcome those limitations, Delta Composants, a French company with more than 35-years-experience team in tailor-made metallurgic solutions transforming wire & metal strips (e.g. mechanical/ electrical cutting, stamping, tumbling), has developed SurfWire, the first machine for surface finishing of hard wire rod to provide new hard rod products for demanding applications in a wide variety of industrial sectors, from medical to aerospace. SurfWire is a sustainable & efficient machine solution: compared to standard finishing processes in series, SurfWire saves 45% energy consumption, has lower O&M cost, reduced waste & emissions (80% less waste water); it is fully automatic and therefore safer. Surfwire machine adaptability & flexibility manufactures rod products for several applications (e.g. automobile injectors or furniture hinges) with unmatchable surface finishing quality (Ra 0.2), high mechanical strength (160-220 daN/mm²), perfectly straight pieces, and a competitive price of 45€/1000 pieces. SurfWire successful launch will be by 2020, boosting our revenues and gross profits to respectively €9.2 M and €4.8 M by the 5th year. Even considering a conservative sales scenario, selling 205M pieces, we would obtain a profitable ROI of 200% after 5 years and will create 7 new job opportunities.

Keywords: metal drawing,wire drawn,hard wire rod,stainless steel,nickel,surface finishing,manufacturing,product quality,hardness
A microfluidic chip for non-invasive, early detection of pancreatic cancer – liquid biopsy (ExoSonic)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-02-01
End date: 2019-07-31
Duration (months): 18.0
Total project cost (EUR): 149997.5
EU funding (EUR): 149996.0
Participants: 1
Project status: CLOSED

Pancreatic cancer is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is only 3% in the UK and this figure has not changed over the past four decades due to lack of specific therapies and inability to detect it early. Several years often elapses from the beginning of the disease to the patient’s diagnosis, suggesting a window of opportunity for early detection. Recently, tiny nanometre-sized vesicles (exosomes) shed by the tumour in the bloodstream, have emerged as powerful circulating biomarkers possessing extremely high sensitivity and specificity, thus paving the way for a new era of non-invasive cancer diagnostics. However, currently the process of exosome isolation and detection is not only highly inefficient, but also technically challenging and inaccessible to hospital laboratories, clinical facilities and resource-poor settings. To address technological constraints of exosome utilisation, we are developing a microfluidic device that leverages cutting-edge microfabrication technology to enable isolation and detection of tumour exosomes from the blood for screening and detecting early-stage pancreatic cancer with unprecedented precision. This chip will have two components, a separation module where exosomes will be isolated from all other blood particles, and a detection chamber that will incorporate technology to achieve ultralow resolution. The first stage of development will be concerned with the fabrication of all components necessary to harness the sensitivity of the exosome biomarker. Following initial testing, we plan to take steps towards commercialisation of the device.

Keywords: exosomes isolation and purification,microfluidic chip,acoustophoresis,graphene based sensor,liquid biopsy technology,early detection of pancreatic cancer
SCIENCE MEETS CITY: SCIENCE HOTEL and SCIENCE OPEN (SCIENCECITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2018-11-30
Duration (months): 7.0
Total project cost (EUR): 112700.0
EU funding (EUR): 40000.0
Participants: 1
Project status: CLOSED

SCIENCE MEETS CITY Science Meets City is a two-day festival, where the general public in Rotterdam and its region meets with scientists and are introduced in their research and its relevance for daily life. The festival facilitates personal encounters between the audience and researchers within an interactive environment. It invites the audience to step in the daily life of researchers and discuss research and its perception by societal stakeholders. This dialogue will be stimulated and enriched with interventions by artists. Special attention will be given to cultural heritage: the work and ideas of Erasmus. The first part of the program on Friday night is Science Hotel, which takes place in the spectacular architecture of the Nhow Hotel on the Rotterdam waterfront. The hotel is scene of a scientific conference on ‘urban related’ research topics, where researchers present and discuss their latest work. This can be either fundamental or applied, but has implications for the great societal challenges in an urbanized context and lead to innovations that improve the quality of daily life, e.g.: life science & health, sustainability, digitalization, logistics & infrastructure, social sciences, economy & lifestyle and philosophy. Entering Science Hotel, visitors from the general public become the delegates of the conference. The visitors will find the researchers who are participating in the conference to be in the process of preparing their talks; meeting peers and societal stakeholders; giving presentations; and participating in debates. Within this context visitors are involved in all these activities. The second part of the program (Saturday morning and afternoon) is Science Open, the actual conference on the campuses of Erasmus University Rotterdam. Visitors are invited to lectures and presentations, ask questions and participate in debates. During daytime, it will enable school pupils in primary and secondary school, students and parents to attend.

Keywords: responsible research and innovation,co creation,general public,stakeholders
Comparative analysis of planarian regeneration - why some worms regenerate while others don’t (RegEvolve)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The ability to regenerate lost body parts is widespread amongst animals, yet humans, for example, can only regenerate specific organs. Why some animals regenerate while others hardly do remains a fascinating conundrum, especially so in face of “survival of the fittest”. Even amongst planarian flatworms, famous for their ability to regenerate from random tissue fragments, species exist that have completely lost the ability to regenerate. This proposal will exploit the unique diversity of planarian regenerative abilities amongst to ask why some worms regenerate while others do not. We and others have established that planarian Wnt signalling acts as critical node in the evolution of regeneration defects. Using this finding as strategic focus for comparisons between regenerating and non-regenerating species, we will investigate i) the cell biological mechanisms that shape Wnt pathway activity; ii) the genomic mechanisms that differentially deploy critical pathway regulators; and iii) evolutionary mechanisms in form of life history trait trade-offs as possible driving force behind the drift of regenerative abilities. Key to the project is a diverse collection of regenerating and regeneration-deficient species that my lab has established. Focused comparisons between our two primary model species D. lacteum and S. mediterranea, employing pan-planarian antibodies and functional genomics, will allow us to understand the detailed causes of altered pathway activity. Comparisons amongst the entire collection of 50 species will provide the necessary breadth for identifying and studying the evolutionary principles that “naturally select” regeneration-deficient planarians. The comparative approach of RegEvolve will thus uniquely bridge the proximate (molecular)- with the ultimate (evolutionary) causes of regeneration defects and such interdisciplinary endeavour between molecular and evolutionary regeneration research will lead to new and profound insights into both fields.

Keywords: planaria,evolution,regeneration