Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EU-CHINA Lever for IPM Demonstration (EUCLID)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Italy,Spain,Belgium,China,Sweden,France,France,France,France,United Kingdom,United Kingdom
Call: EU-China cooperation on IPM in agriculture (H2020-SFS-2014-2, 2014)
Start date: 2015-09-15
End date: 2019-11-14
Duration (months): 50.0
Total project cost (EUR): 3245538.19
EU funding (EUR): 3000000.0
Participants: 20
Project status: CLOSED

More sustainable pest management methods are needed in order to reduce the negative effects of pesticides on human health and the environment. The overall goal of EUCLID is to contribute to secure the production of food for the increasing worldwide population while developing sustainable production approaches to be used in the European and Chinese agriculture. The choice of the crops of interest in EUCLID, i.e. fresh tomatoes, table and wine grapes, and leafy vegetables (lettuces, cabbages, etc.), is based on their economic importance for both European and Chinese fruit and vegetable production, but also for their exemplarity in representing different production systems (field + greenhouse vegetables and ligneous perennial). This means that the solutions of the project could be used models for developing similar actions for other crops. The project is structured in 3 R&D work packages (WP), one WP dedicated to demonstration in field, one for dissemination and a WP devoted to project management. The project will exploit the thorough knowledge developed in the last years on IPM to adapt and optimize those tools and approaches which did not reach the field/market (yet). In addition, the consortium will work on the further development of high potential innovation pest management solutions. The consortium has been selected in order to integrate in the research process, from the very beginning, the main end-users of the project’s results: farmers associations, SMEs, economists, experts in policy. The consortium also has a good coverage of both European and Chinese experts, in order to take advantage of the experience of each region and to more efficiently adapt the pest management solutions to the specific problems of European and Chinese farmers.

Keywords: genetic resistance,biofumigation,biopesticides,rnai,sit related methods,banker plants,pest management oriented crop assemblages,microclimate dss,community ecology based approaches
IFMIF-DONES Preparatory Phase (DONES-PreP)

Framework: Horizon 2020 — Euratom
Programme: Euratom other actions
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Italy,Poland,Belgium,Croatia,Hungary,Poland,France,Portugal,United Kingdom
Call: Support for the preparatory phase for the DEMO Orientated Early Neutron Source IFMIF/DONES (H2020-IBA-EURATOM-DONES-2019, 2019)
Start date: 2019-10-01
End date: 2021-12-31
Duration (months): 27.0
Total project cost (EUR): 4246325.63
EU funding (EUR): 3988290.0
Participants: 16
Project status: CLOSED

The International Fusion Materials Irradiation Facility - Demo Oriented NEutron Source (IFMIF-DONES) is a novel Research Infrastructure based on a unique neutron source with energy spectrum and flux tuned to those expected for the first wall in future fusion reactors, to investigate radiation damage phenomena and to characterize materials irradiated under such conditions. It will also develop a unique high-current high duty-cycle accelerator technology, liquid metal target technology and advanced control systems. Since 2007, the original IFMIF project has been pursued by Japan and the European Union under the Broader Approach Agreement in the field of fusion energy research and in December 2017 Fusion for Energy (F4E)positively evaluated the Spain-Croatia joint proposal to site DONES in Granada (Spain) and at this moment a wide international collaboration is being fostered to design and build the facility. The primary goal of the IFMIF-DONES Preparatory Phase project is to elaborate and draft the consortium agreement allowing for the construction of the facility. During the Preparatory Phase, the Project will deal with the financial, legal and organisational issues related to the international character of the facility during its construction and operation phases. The Preparatory Phase is also the ideal framework to attract other partners, also to ensure the operation and exploitation of the project, such as the already confirmed Andalucía Region Authority and the Spanish Government, EUROfusion and F4E that cover about 75 % of construction costs.
B cell receptor engagement and signalling in chronic lymphocytic leukemia: identify the structural and functional requirements for disease development and progression. (BCRES-CLL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-31
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

B-cell chronic lymphocytic leukemia (CLL), the most prevalent leukemia among adult Caucasians, is a disease characterized by the clonal expansion of B lymphocytes expressing CD5. The B-cell receptor (BCR) plays a critical role in CLL development and progression as indicated by the efficacy of drugs blocking BCR signaling. However, the mechanism(s) underneath BCR responsiveness are not well-defined and CLL remains incurable. In the classical view, an interaction between BCR and extrinsic antigen is responsible for such signalling. The discovery that CLL BCRs can self-associate and signal in the absence of extrinsic antigens (intrinsic binding) highlighted a novel mechanism for BCR engagement and signalling. Growing amount of evidences suggest that both extrinsic and intrinsic engagement are required for leukemia development and progression. Herein, we aim to better define the selectiveness of the two BCR engagement mechanisms and their association with specific biological and clinical characteristics. To better define such elusive associations, machine learning algorithms will be developed and used to define the specific links among the biological data. Specifically, we will i) assess BCR engagement features associated with CLL clinical aggressiveness and responsiveness to stimuli; ii) identify normal B cells expressing CLL-like BCRs and evaluate their engagement features and similarity with CLL B cells; iii) identify genes and genetic pathways distinctly associated with either mechanism of BCR engagement and/or CLL aggressiveness. The successful outcome of this proposal would generate biologically and clinically relevant information for prevention, prognosis and therapy of CLL.

Keywords: chronic lymphocytic leukemia,b cell receptor,immunoglobulin,signalling
Reducing empiricism in luminescence geochronology: Understanding the origins of luminescence from individual sand grains (RELOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Denmark,Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-12-31
Duration (months): 64.0
Total project cost (EUR): 1314963.0
EU funding (EUR): 1116648.0
Participants: 2
Project status: CLOSED

Sediments preserve a history of the evolution of the Earth’s surface and its response to a changing climate – a history that can only be read reliably if we know the age of the sediments. Luminescence dating is widely used in quaternary geology and archaeology, and is applicable to almost all sediments from the last 0.5 Ma – it dates the last time the sediment grains were exposed to daylight. RELOS will improve the reliability of luminescence dating by determining the sources of unexpected spread (over-dispersion) in measured doses derived from sand-sized grains. New hypotheses concerning charge imbalance, charge transport and dose calibration of luminescence signals will be tested by: (i) quantifying the effect of grain size and irradiation geometry/quality on grain-to-grain dose dispersion, and particularly the importance of charge particle equilibrium at these scales; (ii) quantifying dispersion arising from grain-to-grain variations in environmental dose rate; (iii) developing measurement procedures giving the same luminescence response per unit dose as in nature; (iv) developing a dispersion budget and new conceptual/numerical models for luminescence production based on (i) to (iii); and (v) testing the results of these investigations using well-defined natural samples. This project investigates fundamental issues of charge (de)trapping and recombination at small scales that have been completely ignored in previous studies, and problems of luminescence response that are sidestepped in the literature, in part by the unsatisfactory approach of arbitrary data rejection. These studies will result in major improvements in our understanding of the small-scale dosimetry of mixed radiation fields and a step change in the reliability of single-grain luminescence ages. The project links these fundamental studies to clear outcomes of considerable potential value to a variety of fields including earth sciences, archaeology and palaeoanthropology.

Keywords: luminescence dating,charge movement,charge trapping,single grain,quartz,feldspar,exo electrons,natural radioactivity,micro xrf,minimum age model,finite mixture model
Mechanism of Chromatin Replication (MeChroRep)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1723514.0
EU funding (EUR): 1723514.0
Participants: 1
Project status: SIGNED

Each time a human cell divides, it must make an exact copy of its 46 chromosomes. This requires precise duplication of ~6 billion base pairs of genomic DNA and all its associated proteins. Mistakes in this process can lead to developmental defects and cancer. Chromatin is packaged as nucleosomes comprising 147bp of DNA wrapped around a core of eight histone proteins. The nucleosome is a stable structure which must be disrupted each time the double helix is accessed during replication. ‘Epigenetic’ information in the form of covalent histone modifications must be re-established on both daughter strands immediately behind the replication fork. Inheritance of parental histones with their covalent marks must be coordinated with deposition of new histones into nucleosomes. And repressive heterochromatin must be replicated and immediately re-established after replication. Our goal is to achieve a deep understanding of how DNA replication is coordinated with the disassembly and reassembly of chromatin to ensure accurate chromosome duplication. We will use in vitro reconstitution of chromatin replication along with molecular genetics and structural biology to: • Generate a molecular view of how the budding yeast replication machinery, with other key factors, disrupts parental nucleosomes during replication. • Determine how parental nucleosomes are transferred to the nascent daughter strands. • Understand how deposition of new histones is coordinated with the inheritance of parental histones. • Characterise how budding yeast heterochromatin is disrupted and re-established during replication. • Begin studying this process using human proteins, focussing on areas where human replication mechanisms diverge from yeast. This work will underpin our long-term goal of reconstituting functional chromosomes from defined components to understand how DNA replication interacts with gene expression, DNA repair and chromosome segregation.

Keywords: chromatin replication
Added Value for Oral Care (ADVOCATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Ireland,Hungary,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Developing and comparing new models for safe and efficient, prevention oriented health and care systems (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 5993032.75
EU funding (EUR): 5993032.5
Participants: 11
Project status: CLOSED

ADVOCATE brings together top principal investigators from prestigious universities, the public sector, and the private sector to address the most common diseases affecting humanity, as measured by the recent Global Burden of Disease Study. ADVOCATE strives to optimise delivery of oral health and wellbeing to the population in EU Member States. This requires a change in oral health care delivery towards prevention. The change will be achieved by developing a model that promotes a preventive rather than restorative oral health care system: The oral health care model 2020. As the oral health care delivery system is not as overly complex as other health care systems, the oral health care model 2020 may serve as a blueprint for other health care system reforms. The development of this model requires intensive information exchange and engagement of stakeholders to establish a set of key-indicators. These indicators will be used to benchmark health care performance on practice as well as system level. Two types of evidence-based indicators will be selected: Quantitative and qualitative indicators that allow measuring and influencing of either intrinsic motivation or extrinsic motivation incentives towards a patient centred, resilient and prevention oriented oral health care system. ADVOCATE will test this model in a natural environment, and provide evidence-informed policy measures towards its implementation, both for oral health care systems as well as other health care systems. Given the comprehensiveness of the topic, ADVOCATE uses a targeted approach that is entirely focused on the five major root-causes underlying the current suboptimal performance of oral health care systems. Moreover, ADVOCATE has confirmed access to data of eight European oral health care databases; it is well connected to existing initiatives and networks, and has ample support from preventive oriented industry, as exemplified by the financial support provided for the final conference.

Keywords: oral health,prevention,efficiency,services,value,outcomes,health care,system,remuneration
StructUral ProtEins foR Biomedical materials (SUPERB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The SUPERB project will train an experienced researcher (ER), Dr. Diego López Barreiro, in the modelling and manufacture of protein-based polymers for healthcare materials. The ER will combine building blocks of structural proteins like elastin or collagen into de novo fusion protein polymers. The healthcare community is becoming increasingly interested in these polymers as a source of advanced healthcare materials, due to their natural abundance, tuneable degradation, easy processability, cytocompatibility, or controllable physicochemical properties. This project will study how polymer features and processing conditions determine the nanostructure of the materials derived thereof, and hence their macroscopic properties. This will be done through an interdisciplinary approach that will (i) use molecular dynamics simulations to select protein sequences and processing conditions for material manufacture; (ii) biosynthesise selected proteins via fermentative processes; and (iii) fabricate, test and characterise hydrogels or thin film materials for model validation. The excellent knowledge and expertise of the host institution in this crucial field for the EU will ensure the success of this proposal. This project will develop a methodology to improve the rationality and decrease the time needed to develop new protein healthcare materials, reducing animal use and experimental costs. Moreover, while the proposed approach is used here on a limited suite of protein building blocks, it can be applied to any other peptide sequences or biopolymers (e.g., bioactive peptides, bioplastics, nanocellulose), becoming a valuable tool to accelerate the discovery of healthcare materials. Furthermore, the project will support the ER in deepening his expertise in protein materials and expose him to the industrial field. This will also enhance his research, project and IPR management skills, acquiring necessary competences for professional maturity and an independent career.

Keywords: protein biomaterials,healthcare biomaterials,bioreactors,downstream processing,computational modelling
Baryonic operators in conformal field theories (BOICFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

The current theoretical description of the fundamental constituents of matter is the Standard Model of particle physics. Despite the unprecedented experimental verification, most of its predictive power is limited to the regime where particles interact weakly, hence impeding the study of bound states, such as baryons, where interactions are strong. This proposal aims to study suitable generalizations of these particle excitations – "baryonic" operators composed of a number N of fundamental fields at a common point in spacetime – in quantum field theories that possess conformal symmetry and admit a large-N limit. These conditions are essential for the methods used in this proposal, which are based on quantum integrability of the relevant theory and on techniques for analytic resummation of Feynman diagrams. The proposed research will extend in a non-trivial way the recent progress in solving correlation functions at finite coupling in maximally supersymmetric Yang-Mills theory. Specifically, we plan to advance the state of the art of integrability, in the form of the Quantum Spectral Curve formalism originally designed for two-point correlators, to describe a class of three-point correlators involving baryonic (also known as determinant or giant-graviton) operators. We also strive to achieve a finite-coupling description of baryonic correlators through an appropriate diagrammatical methodology. Specifically, we plan to realize this goal in the non-supersymmetric gamma-deformation of the Yang-Mills theory and, finally, to adapt it to the quantum mechanical model proposed by Sachdev, Ye and Kitaev. The complicated perturbative description of baryons is both the challenge and the novelty, compared to earlier works for single-trace operators in the same theories. This proposal details a plan for dissemination and communication of its results to specialists and the general public, as well as training for the benefit of the experienced researcher.

Keywords: baryonic operators,cft correspondence,integrability,conformal field theory,feynman diagrams
Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception (OptoVision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-12-01
End date: 2021-05-31
Duration (months): 66.0
Total project cost (EUR): 1405000.0
EU funding (EUR): 1405000.0
Participants: 1
Project status: CLOSED

In order to achieve a more complete understanding of neocortical brain functions in health and disease, we need to delineate the computations of specific cell populations and how they dynamically exert their impact on connected target neurons. Here, I propose to investigate the functions of neurons in layer-6 of primary visual cortex (V1) and their influence on connected neurons, i) in the lateral geniculate nucleus (LGN) of thalamus, and ii) to more superficially located V1 cells, during visual perception in non-human primates (NHP). My core hypothesis is that due to their unique connectivity with LGN on one hand and layer-4 of V1 on the other hand, layer-6 neurons are in an ideal position to facilitate the transmission of visual information from LGN to V1 when spatial attention is allocated to specific visual targets. The central aim of my investigations will be to delineate how the computations and network interactions of layer-6 neurons dynamically change during attention and ultimately lead to improved behavioral performance. To this end, selective targeting and manipulation of LGN projecting V1 layer-6 neurons will be enabled using the methods of optogenetics (ChR2) and viral delivery techniques. Methods to measure brain activity and assess the impact of optogenetic stimulation will include behavioral assessment, functional magnetic resonance imaging (fMRI) and extra-cellular multi-electrode electrophysiology. Data analysis will include measures of directed (functional and effective) connectivity and en-/decoding approaches using a (predictive coding) Bayesian inference framework. With this approach we will gain new insights into the basic principles of information flow in the visual system. Beyond their immediate impact on basic science, the results of the experiments will be contributing towards a better understanding of the diseased brain such as in schizophrenia or attention-deficit-hyperactivity (ADHD) syndrome.

Keywords: vision,attention,optogenetics,neurophysiology,cortex,thalamus