Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting how the Drosophila brain regulates behavioral sequences of feeding to ensure protein homeostasis (P-appetite)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-11-03
End date: 2021-11-02
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Balanced intake of nutritional amino acids is a key determinant of fitness across animal phyla including Drosophila, mice and humans. Imbalanced protein intake have severe implications for health, lifespan and fecundity. To maintain protein homeostasis, animals evolved physiological, neuronal and behavioral strategies that secure balanced intake of dietary amino acids. Altogether, these strategies give rise to protein-specific appetite where deficiency of a dietary amino acids subsequently triggers increased consumption of food sources rich in protein. Drosophila feeding behavior, like many animals including humans, comprises hierarchically-organized behavioral sequences that are tightly regulated by the protein state of the fruit fly. These behavioral sequences include meals that are organized into feeding bursts composed of multiple sips of the food source (the feeding microstructure). It has been shown that deprivation of dietary amino acids specifically modulate the duration of the feeding bursts to trigger compensatory consumption of protein-rich sources. However, the modulatory pathways and neural circuits that ensure protein homeostasis by regulating the feeding microstructure with such specificity remain elusive. In the proposed project we aim to identify and characterize modulatory pathways and neural circuits controlling protein-specific appetite. To achieve this, we will combine high-resolution behavioral analysis of feeding with unprecedented neurogenetic toolkit of Drosophila to monitor and manipulate activity in defined subsets of neurons. By using anatomical and functional neural-circuit mapping strategies, we will provide a circuit-level explanation for the regulation of behavioral sequences underlying protein-specific appetite.

Keywords: drosophila,feeding behavior,nutrient homeostasis,behavioral sequences,neural circuit mapping
COupling data and techniques for BReakthroughs in EXoplanetary systems exploration (COBREX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2495266.0
EU funding (EUR): 2495266.0
Participants: 1
Project status: SIGNED

Exoplanetology has become a major topic in astronomy over the last 30 years. New observing capabilities and modelling have revolutionised the understanding of how planetary systems form and evolve. Yet, the 5-20 au region, where the giant planets formed by accretion of gas on to a solid core are supposed to form predominantly, remains barely explored due to instrumental limitations. GAIA and the E-ELT instruments will be well suited to explore planetary systems at this scale. However, I believe that exploring this region is possible right now, at a small cost, with the use of recent innovative signal processing developments applied to current High Contrast Imaging (HCI) data and/or the use of high-performance, AO-fed medium/high resolution spectrographs. With COBREX, I want to apply such new data processing techniques on the largest library of SPHERE and GPI HCI data to gain at least one order of magnitude (hence a gain of ~3 in mass/separation) on current planet and disk detection limits in the 5-20 au region. This will allow witnessing, for the first time, analogues of our Solar System Giants at early ages, and constraining the distribution of GPs in the 5-20 au. Combining in different ways various data (HCI, GAIA, RV) will allow exploring the demography of young giant planets at all separations. Then, I want to couple HCI with medium/high resolution spectroscopy, to find and study planet properties into exquisite details, and investigate in an unprecedented way the link between disks and planets. Finally, I wish to explore the possibility of imaging remote magmatic super-Earths in the near future thanks to such improvements.

Keywords: exoplanets,formation of planetary systems,high contrast imaging,spectroscopy
Pollutants and greenhouse gases in the atmosphere - understanding gas-gas and gas-solid interactions towards a cleaner atmosphere (ATMOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,Algeria,Spain,China,France,France,United Kingdom,Chile,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-04-01
End date: 2026-01-31
Duration (months): 70.0
Total project cost (EUR): 892400.0
EU funding (EUR): 892400.0
Participants: 12
Project status: SIGNED

ATMOS denotes a consortium of eleven scientific institutions, six beneficiaries and five partners which main objective is to establish a collaborative effort for the study of scientific problems related to the atmosphere pollution elements, with an emphasis on training students in atmospheric sciences. This project points to: 1) create a network of highly qualified multidisciplinary researchers which strengthens the collaboration among researchers from EU and third countries; 2) develop novel approaches aiming at characterizing the atmospherical pollutants and their interactions, and communicating the results to the general public; 3) share and disseminate scientific information which contributes to atmosphere pollutants detection and the development of innovative gas capture techniques; 4) enhance the academic prospects of the participants, in particular, of female researchers from third countries. ATMOS provides a novel multifaceted approach. The key advances are highlighted in three scientific packages. The main novelties of the project are: a) The spectroscopic description of rather complex uncharacterized organic volatil compounds focused to their detection by the large scale and local instruments; b) the study of reactive processes to understand in detail the connection between VOCs and atmospheric radicals and to describe the relevant role of radicals; c) the exploitation of some pollutants as reagents towards the preparation of innovative materials, contributing to the reduction of their presence in the environment. ATMOS employs laboratory techniques for spectroscopy and molecular fluid dynamics, atmosphere simulation chambers, and technical tools (air monitoring station or synthesis of new capture materials), combined with quantum chemical calculations and theoretical developments. Secondments and networking activities, such as two workshops, a winter school, and an international conference, are designed to facilitate the interdisciplinary work.

Keywords: atmosphere,spectroscopy,pollutants,radicals,photochemistry,gas capture
Centre of Excellence in Production Informatics and Control (EPIC)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Austria,Germany,Hungary
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 489375.0
EU funding (EUR): 489375.0
Participants: 6
Project status: CLOSED

The main, overall objective of the proposal is to establish the Centre of Excellence in Production Informatics and Control (EPIC) as a leading, internationally acknowledged focus point in the field of production informatics, management and control representing excellence in R&D&I. EPIC will be constituted and run through the cooperation of the Institute for Computer Science and Control, Hungarian Academy of Sciences (MTA SZTAKI), two faculties of the Budapest University of Technology and Economics (BME) and four institutions of the Fraunhofer-Gesellschaft (FhG) under the coordination of the National Innovation Office (NIH), Hungary as a governmental decision maker. The EPIC project will lead to: 1. The upgrade of MTA SZTAKI as existing Centre of Excellence of the EU. 2. The further development of the Fraunhofer-SZTAKI Project Centre for Production Management and Informatics (PMI), a joint initiative of FhG and the Hungarian Academy of Sciences (MTA), established in 2010. (The cooperating Fraunhofer institutions have been the Fraunhofer Institute for Manufacturing Engineering and Automation (IPA), Stuttgart and Fraunhofer Austria (FhA)). 3. The extension of the present cooperation with two faculties of BME, i.e., the Faculty of Mechanical Engineering (GPK) and the Faculty of Transportation Engineering and Vehicle Engineering (KJK), on the one hand, and with two additional institutes of FhG, i.e., the Institute for Production Technology (IPT), Aachen and the Institute for Production Systems and Design Technology (IPK), Berlin. 4. The close cooperation with SMEs as well as with large industrial firms. Due to direct, institutionalized and supported interactions with Fraunhofer, not only the scientific capabilities of the Hungarian partners but also their ability to transfer scientific results to industry-relevant applications will be greatly enhanced. By this way a “high speed lift” to innovation culture and performance in Hungary and the CEE region will be provided.

Keywords: production informatics and control,cyber physical production systems,robust,cooperative systems,innovation,technology transfer
Exploring the role of the mitochondrial alternative respiration in carotenoid biosynthesis during tomato fruit ripening (ARCATOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-10-01
End date: 2020-12-15
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Tomato is one of the most economically relevant crops in the world and is the main model system for fruit ripening studies at biochemical, genetic and molecular levels. In this climacteric fruit, a sudden increase in respiration takes place at the onset of ripening, usually in concert with increased production of ethylene that eventually impacts fruit color, firmness, taste, and flavor. During ripening, tomato accumulates high contents of health-promoting carotenoids (pro-vitamin A, antioxidants), which require a high production of carbon precursors and ATP. In this respect, both mitochondrial and chromoplast respiration have been proposed to play important roles in fruit ripening and carotenoid metabolism. The general aim of this project is to determine the contribution of mitochondrial respiration to the supply of energy and carbon for the production of carotenoids in tomato fruit during ripening. In particular, we will perform metabolomics of genetically modified tomatoes with altered mitochondrial and chromoplast respiration at different ripening stages. Furthermore, 13C- and 14C-labelling experiments will be performed to trace the fate of carbon from primary to secondary metabolites. In parallel, we will measure the relative glycolytic and TCA cycle fluxes and, for the first time in tomato, the in vivo activities of mitochondrial electron transport chain pathways by using the 18O fractionation technique. Combining these data with the analysis of transcript and protein levels of the main components of respiratory and carotenoid pathways and mathematical modelling will unveil novel metabolic checkpoints and connections between primary and secondary metabolism during fruit ripening. The generated new insights should contribute to the implementation of new biotechnological approaches to produce fruits with enhanced levels of carotenoids and other health-promoting secondary metabolites.

Keywords: health promoting carotenoids,metabolomics,alternative respiration,tomato
Sacrificial Thermoplastic Injection Moulding platform for manufacturing small and complex metal and ceramic components (STIM-MC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2018-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

AddiFab has developed the first sacrificial thermoplastic injection moulding platform to support the manufacturing of small/medium size, complex and traceable metal and ceramic components with high precison – STIM-MC. AddiFab’s innovative solution is the first to remove the costly and time-consuming gap between prototyping and commercialization ramp-up. This is only possible due to AddiFab’s proprietary material and process which uses printed objects as intermediary process tools (moulds). It runs in a single platform which integrates the automatic production and post-processing of moulds. With single-use moulds produced automatically, prototypes and components with mould-like quality can be launched for in-market validation and easily modified. Thus, the STIM-MC platform reduces development costs, mitigates the risks of product failure and increases process efficiency, while enabling wider benefits for the healthcare, consumer products and automobile industry through new cost-effective materials. Through the successful development and implementation of the STIM-MC project, AddiFab will be in a strong position to exploit the micro and powder injection moulding markets and enhance its profitability by the stream of the sales, with an expected cumulated revenue of €71 million, 5 years after project completion.

Keywords: precision plastic moulds,ceramic,metals,advanced manufacturing
Indicator Monitoring for a new railway PAradigm in seamlessly integrated Cross modal Transport chains – Phase 2 (IMPACT-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Germany,Sweden,Türkiye,Sweden,Sweden,Sweden,Sweden,France,United Kingdom,Portugal,Portugal
Call: Improving railway services for users and operators (H2020-S2RJU-CFM-2017, 2017)
Start date: 2017-09-01
End date: 2022-12-31
Duration (months): 64.0
Total project cost (EUR): 3153652.5
EU funding (EUR): 3153652.5
Participants: 26
Project status: SIGNED

This Project aims to perform the socio-economic Research for Shift2Rail, to develop the SPD Scenarios and the KPI integrated assessment. Smart Maintenance, Standardisation, Integrated Mobility Management and Human Ressources are cross-cutting activities of Shift2Rail as well and consequently topics of the Project, too. The objectives of this proposal IMPACT-2 are: - Evaluating the effects for mobility, society and environment induced by new technology solutions and developments, - Introducing relevant targets and needs to create a more attractive, a more competitive and more sustainable rail system - Defining System Platform Demonstrators (SPD) that represent future application use cases - Defining Key Performance Indicators (KPIs) that enable the monitoring and assessment of the Shift2Rail overall target achievement. - Smart Maintenance - Prepare an efficient process for bringing Shift2Rail results into standardisation - Develop a common platform for the intelligent mobility management - Human ressources The project IMPACT-2 is planned to fulfil all respective topics of the Shift2Rail Annual Work Plan 2017.

Keywords: intelligent mobility management,socio economic impact,key performance indicators,smart maintenance,human capital,standardsiation
Chemical Reaction Networks: signal amplification, spatiotemporal control, and materials (CReaNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Israel,Germany,Sweden,Switzerland,France,France,Netherlands,United States,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 3939065.5
EU funding (EUR): 3939065.5
Participants: 14
Project status: SIGNED

Chemical reaction networks are ubiquitous in living systems, and hold great promise for the generation of future ultrasensitive sensors, for finding advanced production schemes towards high value chemicals and for enabling future autonomous and adaptive materials. To become a technology leader in this area, it is imperative for EU to invest in i) training highly skilled researchers and ii) conducting research interfacing fundamental sciences and technologically relevant applications. This ETN focuses on strengthening EU’s innovation capacity via an integrative EU doctoral training on “Chemical Reaction Networks: signal amplification, spatiotemporal control, and materials”. It brings together an interdisciplinary team of 6 proven academic experts and 4 non-academic partners to inspire and educate a new generation of ESRs (early stage researchers) to become leaders in this emerging research area of chemical reaction networks – a subject which is not specifically taught at EU universities. We provide the ESRs with a comprehensive, structured, interdisciplinary and intersectorial training, and bridge fundamental research and applications with a cutting-edge research program. The objective of the research program is to unravel design principles for chemical reaction networks, find pathways to modulate them from the outside, and develop them towards applications for ultrasensitive sensors and autonomous materials with time-programmed operation. The close interaction between academia and private sector will ensure a multifaceted view, and a swift transfer of fundamental discoveries to applications. The intersectorial partner setting, together with the balanced training of research-related and transferable skills, will enhance the career perspectives of the ESRs in both the academic and non-academic sectors. This ETN will form ESRs with highest levels of creativity, innovation capabilities and entrepreneurial mindsets, and thus promote EU leadership in nanosciences.

Keywords: reaction networks,feedback,ultrasensitivity,non equilibrium,dissipative self assembly,detection
Feasibility study for Titan Fire System S.L. (TFS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-04-01
End date: 2018-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The number of fires per inhabitant has increased over a 250% in the world from 2008 to 2015. Only in 2015, the number of deaths almost reached the 45,000 people in over 3.5 million of fires attended. Infrastructures and vehicles fires account for over a 50% of the total. The economic cost of fire is also relevant. Only in the US, the total cost of fire in 2011 was estimated at $329 billion, or roughly 2.1 percent of U.S. GDP. This cost represents a 34% increase over 1980. Prevention measures for fires are based on devices like CO2 or temperature detectors, alarms and mechanical items like extinguishers, firefighting fixtures or pumping groups. These mechanical components are subject to visual inspections from time to time which in the mid-term is a major danger. These old-fashioned procedures for inspection and maintenance may cause major damages in the case of the fire, and have a high-cost in terms of money but also lives. A simple malfunction of the mechanical items can quickly turn fatal. Titan Fire System (TFS) has created and patented a technology to better monitor, analyse and prevent fires is all sorts of facilities, with a special focus in critical infrastructure. This technology will disrupt the market of fire prevention systems as they are now conceived worldwide. TFS is comprised by a (1) Patented digital manometer or smart manometer; (2) Patented module to receive/transmit the signals from/to the manometers to/from the alarm receiving system (3) Software including a desktop application and an app; (4) Titan cloud to analyse and alert about incidences. TFS will allow to improve safety against fires, to significantly reduce costs in a security installation and to modernise a very traditional sector. TFS has already signed their first agreement with a distributor in Spain to start their installation next year.Initial estimations of the company indicate they expect reaching over €17m sales with a net benefit of €5.5m in 2021.

Keywords: fire security,smart manometer,fire extinguishing system,cloud,security,critical infrastructure