Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pattern formation in systems of magnetic spinners (Pattspin)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Latvia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-08-15
End date: 2026-08-14
Duration (months): 24.0
Total project cost (EUR): 162499.2
EU funding (EUR): 162499.2
Participants: 1
Project status: SIGNED

The collective behavior of magnetic particles in rotating fields opens challenging physical questions and suggests their role as model systems for nonlinear behavior in soft matter physics. Their non-equilibrium phase diagrams show a wide range of patterns. From the experimental perspective, the control by an external magnetic field of collective dynamics of particles with permanent dipoles, namely magnetic spinners, offers a promising route for applications such as chiral fluids, cargo transport, and targeted delivery. However, the full comprehensive understanding of pattern control of the magnetic-responsive aggregates remains challenging and it lacks a profound investigation, which is crucial for future applications. This proposal aims to investigate the pattern formation in systems of magnetic spinners by theoretical approaches, which are compared to experimental data, to find characteristic parameters and rules. Studies will make use, of particle-resolved computer simulations such as Langevin Dynamics Simulation, based on Langevin equations to investigate the interplay among magnetic, hydrodynamics, and lubrication interaction.

Keywords: softmatter,molecular dynamics simulations,magnetic particles
Optical circuit switched time sensitive network architecture for high-speed passive optical networks and next generation ultra-dynamic and reconfigurable central office environments (OCTAPUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Greece,Italy,France,Germany,Denmark,United Kingdom,Israel,Netherlands,Belgium
Call: Advanced optical communication components (Photonics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 5883941.25
EU funding (EUR): 4789661.0
Participants: 12
Project status: SIGNED

Skyrocketing capacity demands and emerging 5G and industrial internet URLLC applications currently pose a new strict latency-oriented framework calling urgently for new radical architectural changes at the key aggregation infrastructure being in local proximity to the subscribers: the Central Offices (COs). A careful look into the CO reveals a capacity-latency predicament underlining the need for the employment of innovative technological solutions, with photonics emerging as the key enabling technology, that will establish a new NGCO ecosystem where component-level advancements can yield unparallel architectural benefits. OCTAPUS aims to deliver an agile, low-cost and energy-efficient PIC technology framework that will re-architect the NGCO ecosystem, transparently upgrading its capacity to 51.2Tb/s and beyond, through an innovative optically-switched backplane and transceiver toolkit. To realize its ambitious goals, OCTAPUS will leverage the novel integration of antimony-based Phase Change Materials (PCM) on the low-cost SiN to develop for the first time a non-volatile ns-scale optical switch technology for developing an ultra-high capacity optical backplane. OCTAPUS will also deploy a versatile portfolio of InP-based O-band optical components that will enable the realization of 50G low-power board-to-board and long-reach PON transceivers, securing 4x and 8x energy saving to existing state-of-the-art solutions, while reaching up to 37.5% cost improvement against conventional EML solutions, through its monolithic fabrication approach. Moreover, OCTAPUS will equip its novel PICs with low loss and compact interfaces to fibers, through advanced glass diplexer-embedded-interposers. Finally, OCTAPUS will synergize the developed optical components in a novel NGCO architecture, supporting 3 layers of traffic with deterministic latency guarantees for URLLC services, through the incorporation of reconfigurable express light paths along with TSN functionality.

Keywords: optical switches,optical transceivers,pon transceiver,optical backplane,central office
Social Economy Transition Skills (SETS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Belgium,Italy,France,Slovenia
Call: Green and digital skills and training needs for a just transition (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 521068.02
EU funding (EUR): 489873.38
Participants: 7
Project status: SIGNED

SETS Project aims at developing, testing and disseminating suitable skills development programmes and training modules, to foster the Green and Digital transition of Social Economy Organisations (SEOs). The project activities will also prepare, through a specific ICT-driven impact assessment & management methodology, future scale-up of the project outcomes through other funds (Cohesion Funds, EIT, Interprofessional funds) and leverage its potential among private and public stakeholders. SETS will also support the skills development of companies providing digital solutions and innovative technologies and VET providers for SEOs. The project will follow a work plan based on seven interconnected work packages: management and coordination (WP1), Skill gap analysis (WP2), Development of trainings (WP3), Piloting and testing (WP4), Certification and recognition (WP5), Assessment, promotion and scale-up of the project impact (WP6), Dissemination and communication (WP7). The rationale for formulating the SETS consortium is based on the creation of a value chain at two levels, national level and European level. The partnership covers 4 countries (BE, IT, FR, SI), but the skill gap analysis will be run at pan-European level as 2 of the beneficiaries are EU-level umbrella organisations or support structures, while the testing and implementing of skills development programmes and training will be carried out in France and Slovenia The consortium combines: • DIESIS: A EU Level support structure for SEOs • ALL DIGITAL: a pan-European association working to enhance digital skills • TIRESIA Politecnico di Milano: a technology, innovation and research centre for social impact, in Italy • OPEN IMPACT: an innovative start-up and accredited spin-off of the University of Milano-Bicocca • SOGA: a French think-tank engaged in the digital transition of SEOs • PRIZMA: a Slovenian non-profit organisation that develops programmes and projects related to lifelong career orientation.

Keywords: digital transition green transition skills,social economy social innovation training programmes
Regulation Of Stress and Early-life Brain Development (ROSEBuD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 311292.48
EU funding (EUR): 311292.48
Participants: 2
Project status: CLOSED

Early-life stress and its regulation define adult resilience on stress, well-being, and mental health. Previous research shows that the presence of a caregiver during early life is important for stress regulation, enabling safety feelings, exploratory behaviour, and regulation-related brain development. However, real-time stress experiences have not been examined in those studies and only selective parameters of the stress regulation mechanism have been considered, rather than multiple modalities and their complex interaction. ROSEBuD aims to describe the mechanisms of early-life stress and stress regulation, with and without the presence of a caregiver, in terms of physiological and endocrine synchrony (O1), brain structure and functional connectivity (O2), as well as on effects on memory formation (O3). The project tackles the limitations of existing research with the innovative combination of (a) a naturalistic experimental setting, i.e. real-time exposure to mild, school-like stressors and similar to real-life presence of a caregiver,(b) multi-modal data acquisition, incl. cutting-edge neuroimaging techniques (Diffusion Tensor Imaging, DTI-MRI, and magnetoencephalography, MEG) for optimal spatial and temporal resolution in the study of structural and functional connectivity, (c) state-of-the-art measures of neuroendocrine and physiological synchrony and memory, and (d) advanced analytical methods. Bridging interdisciplinary expertise in stress and memory research (outgoing phase, CISA, Geneva; supervised by Prof. Rimmele) and multilevel and MEG analyses (return phase, FORTH, Heraklion; supervised by Prof. Simos), ROSEBuD project aspires to make an important, timely and impactful contribution to basic and applied research, as well as to the society, informing about the crucial role of early-life stress regulation. Lastly, this work will enable me to synthesize and expand my research interests and skills, and promote my academic or non-academic career prospects.

Keywords: stress regulation,stress,early life,childhood,development,brain,neural correlates,neuroendocrine,physiology,memory
Enabling personalised diagnosis, treatment, and stratification through whole-body metabolic modelling of an individual’s genome, metabolome, and metagenome. (AVATAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1999991.0
EU funding (EUR): 1999991.0
Participants: 1
Project status: SIGNED

The increasing availability of whole-genome sequences will ultimately transform medicine into personalised medicine. To realise this potential, we need to understand which of the millions of genetic variants in a person’s genome can alter a phenotype. Genome-wide association studies (GWAS) have associated many genetic variants with thousands of phenotypic traits. Metabolomics has further informed GWAS. However, these methods do generally not consider the biochemical network connecting genetic variants with the metabolic phenotype. Additionally, extrinsic factors, such as diet and the microbiome, also modulate the metabolic phenotype. A computational systems approach is required to untangle this complex interplay. In AVATAR, I shall develop and apply a novel mechanistic computational modelling framework that will significantly expand cutting-edge computational models of whole-body metabolism. The novel in silico models will mechanistically describe the network of genetic variants, genes, proteins, and biochemical reactions, as well as underlying physiological processes that are influenced by microbial and nutrient metabolism. I shall devise a novel algorithm to predict phenotypically relevant genetic variants based on a person’s genome and metabolome. The validated algorithm and the modelling framework shall then be used for two distinct biomedical proof-of-concept studies: the diagnosis and diet-based treatment of inherited metabolic diseases and the metabolic pathway-based stratification of individuals with cognitive impairment. AVATAR will enable novel insights into the genotype-phenotype-environment relationship by enabling systematic mechanism-based analyses of genetic variants, diet, and the microbiome. This ground-breaking, innovative, multidisciplinary project will influence precision medicine by providing a personalisable modelling analysis framework that may ultimately provide a foundation for computer-guided diagnosis and treatment strategies.

Keywords: computational modelling human metabolism inherited metabolic diseases cognitive impairment microbiome
High-Purity Lithium Hydroxide Recovery via Anti-Solvent Crystallisation (HiLi) (HiLi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 2
Project status: SIGNED

The transition to a climate-neutral Europe relies on securing a continuous and sustainable supply of lithium, a key component in electric vehicle (EV) batteries and renewable energy storage systems. However, Europe's dependence on lithium imports, compounded by the environmentally harmful and complex extraction processes used globally, present major risks to the continent's energy and economic security. This proposal addresses the urgent need for a cost-effective, selective and sustainable method for high purity lithium hydroxide recovery for a advanced battery technology from hard-rock-ore-derived lithium sulfate (Li2SO₄) solutions. Our innovative approach leverages antisolvent crystallization to efficiently and selectively recover lithium hydroxide while minimizing environmental impact. Unlike conventional methods, which are costly, and produce significant chemical waste, our process streamlines recovery, improving yield, purity, and control over crystal size, phase, and morphology. By directly crystallizing lithium hydroxide monohydrate and sodium sulfate decahydrate, this method reduces processing steps and eliminates the need for intermediate lithium carbonate production, providing a more sustainable and cost-effective alternative. The proposal is timely and aligns with the Europe's strategic objective to strengthen its battery industry and reduce dependency on critical raw materials. As demand for lithium increases, our method offers a scalable solution that can be commercialized to benefit the entire EU battery ecosystem. With extensive experience in crystallization of pharmaceuticals and critical metals, I am well-equipped to work on this project, ensuring that the innovative process not only meets technical and environmental benchmarks but also adds significant value to Europe's industrial landscape. Our project will enhance Europe's technological sovereignty, reduce environmental impacts, and contribute to the sustainable growth of EV battery sector.

Keywords: battery metals,critical raw materials,extractive metallurgy,hydrometallurgy,lithium,sustainable metallurgy,antisolvent crystallization
Simulating non-Hermitian many-body topological phases with giant atoms (SING-ATOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-16
End date: 2026-08-15
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Non-Hermitian many-body topological phases are drawing substantial attention due to their potential for novel quantum technology. In particular, these phases hold promise for large-scale quantum computations, a technology with substantial scientific and economic impact. However, due to computational difficulties, it remains a remarkable challenge to investigate these phases. Quantum simulation offers a path to overcome this challenge. Yet, efficient simulation of non-Hermitian many-body topological phases is absent. In this project, I will address this gap by theoretically designing novel protocols to simulate non-Hermitian many-body topological phases with giant atoms, a newly prominent quantum optics platform. Notably, giant atoms offer greater control over interactions compared to their smaller counterparts, thus making them versatile for quantum simulation. To achieve the project's goal, I will first design a novel protocol for quantum simulation within the simplest regime of 2 giant atoms, and subsequently generalize it to an advanced protocol for simulating a non-Hermitian topological spin chain. I will perform the theoretical analyses combining many-body methods and quantum simulation methods. This multidisciplinary approach will maximize the outcomes: i) a novel protocol for quantum simulation with giant atoms and ii) an efficient simulation of non-Hermitian many-body topological phases. Consequently, this research project will open up an interdisciplinary research field between non-Hermitian many-body physics and giant atoms, and pave the way toward the long-term goal of realizing large-scale quantum computations. My expertise in non-Hermitian many-body topology and my host's expertise in giant atoms are complementary for carrying out this project. I will establish a detailed dissemination plan to maximize the impact of this project, and a detailed training and transfer plan to benefit the host group and to promote my career to the next level.

Keywords: non hermitian physics,many body physics,giant atoms,quantum simulation
Isolation of bacteria and extracellular vesicles from body fluids for improved diagnostics (PREVAID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: SIGNED

This project aims to deliver a microfluidic platform capable of isolating bacteria and Extracellular Vesicles (EVs) at high throughput and high recovery rates from clinical samples, and perform the necessary downstream analysis for the diagnosis of diseases requiring earlier/urgent treatment. Currently, long incubation steps required for identification and susceptibility testing of pathogens make clinicians to prescribe broad-spectrum antibiotic treatments in sepsis cases upon hospital admission, and in nearly half of cases this treatment fails. On a different timescale, the lack of symptoms until late stages of some cancer types such as pancreatic cancer means a high mortality rate. Profiling molecules contained in EVs —most importantly DNA, RNA, proteins and lipids— promises a powerful diagnostic tool as biomarkers for cancer, but current EV isolation methods relying on ultracentrifugation are lengthy and can potentially damage the information enclosed. Microfluidics could provide a high yield, high throughput solution for isolation and enrichment of such particles. However, current approaches do not meet requirements of throughput and/or detection limit, and lack insightful physical understanding. I propose to use novel fluid dynamic and electrokinetic models for particle manipulation in microfluidics, with state-of-the-art fabrication methods to deliver a device capable of rapidly isolating and enriching samples containing (a) bacteria at low concentration (few hundreds per mL) to be integrated in a platform with the potential to identify and perform ASTs in possible bacterial infections in body fluids that avoid culture steps in current gold standards and potentially allow a ten-fold time reduction from sample to answer; (b) EVs to replace current ultracentrifugation methods. Thus, a future clinical implementation of the project outcomes will have large economic and societal impact.

Keywords: bioparticle separation,lab chip,fluid dynamics,electrokinetics,bacteraemia,extracellular vesicles
AI-based clinical software for fully automated Cardiac Magnetic Resonance reporting (AI4CMR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 2505488.57
EU funding (EUR): 1753842.0
Participants: 1
Project status: SIGNED

AI4MedImaging is developing a disruptive clinical software - AI4CMR.Plus - for fully automated assessment of heart function and structure based on Cardiac Magnetic Resonance (CMR), with the potential to disrupt the current state of art of cardiovascular disease (CVD). By simplifying, accelerating, and enhancing CMR assessment, AI4CMR.Plus is the long-sought key to unlock the full potential of magnetic resonance as routine and gold-standard heart imaging tool, towards a new era of high-precision CVD diagnosis. To sooner-than later gain visibility, market traction, and consolidate our value chain, we have launched an MVP version of our software - AI4CMR - to the EU market, early this year. With EIC support, we now aim at accelerating AI4CMR.Plus development and preparing its market launch for 2025. Commercial exploitation of AI4CMR.Plus will prompt a steady company growth, strengthen the EU digital sovereignty and, importantly, have life-changing impact to millions threatened by CVD.

Keywords: cmr reporting,automatic triage,diagnostic tool,cardiac resonance image,software medical device