Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lyfta: an immersive educational storyworld platform (Lyfta)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Finland
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We need encouraging stories to help us better understand our world and each other. Lyfta aims to become a leading distributor of engaging, 21st Century learning content through its own platform, and answer to the growing need of interaction in teaching and 21st Century skills-based learning. Lyfta, an innovative SME, designs and produces high-quality, immersive learning environments, using virtual reality & augmented reality (VR&AR) and interactive 360⁰ storytelling combined with Finnish pedagogic expertise to suit the global needs of learning in the future. Lyfta is made by educators, for educators. Lyfta has a very experienced, passionate team with proven track records in the media and education technology (EdTech) industries. All the products offered through Lyfta’s platform include extensive teaching materials suited to modern, Western curricula. Lyfta’s products have already been piloted in schools in the UK and Finland. Strong growth potential has led to rapid growth of the software and services segment of the EdTech market. Education has been estimated to be the most growing sector in the global market of VR & AR. Lyfta already has a solid position in the VR and interactive storytelling industry, and is set to make a change in the way people learn. In this project Lyfta aims to develop new business models and concepts for its educational platform. In its vision, Lyfta will be the Netflix of 21st Century learning, where educational institutions and organisations across the world use the platform to purchase high quality off-the-shelf educational resources.

Keywords: education,technology,learning,environments,virtual reality vr,augmented reality ar,pedagogy
Re-evaluating the Eleventh Century through Linked Events and Entities (RELEVEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1944816.0
EU funding (EUR): 1561372.25
Participants: 2
Project status: SIGNED

The aim of the RELEVEN project is to develop and test new ways for digital data about historical phenomena to be created and curated so that it is most useful to historians, and to apply these methods to a methodologically challenging yet very significant aspect of medieval history. The approach is to re-frame both existing and new historical data as assertions, often sourced but always linked to an authority; this allows data to be manipulated according to source and authority, and also allows assertions themselves to be linked depending on whether they corroborate, depend on, or conflict with each other. The novel aspect of this methodology is that it takes to its logical conclusion something that historians all readily acknowledge and that is especially apparent for pre-modern history: that there are very few, if any, simple and undisputed facts. A related challenge is the contextualisation and reuse of existing online data for the period, to avoid its going to waste. The approach is tested by taking a broad trans-regional approach to the history of the late 11th century (c. 1030–1095), centred broadly in the eastern half of Christendom but incorporating developments elsewhere, especially in the newly Christianised kingdoms of central Europe. The looming weight of the First Crusade at the century's end means that while certain regional or proto-national narratives—particularly for western Europe—are well-developed, they tend to obscure the larger trans-regional trends of communication and contact, particularly in eastern Christendom. By drawing upon the depth of scholarship and the plethora of digital resources that have emerged for this period in sub-disciplines such as prosopography, textual scholarship, corpus-based research, and archaeology, and by framing this scholarship in terms of assertions whose authority is traceable, it will become possible to look at the history not just from "the eastern perspective", but from several.

Keywords: data modeling,linked open data,trans regional studies,christian near east,medieval studies
Dynamic EU building stock knowledge hub (BUILTHUB)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Spain,Spain,Germany,Italy,Belgium,Sweden,Greece
Call: European building stock data 4.0 (H2020-LC-SC3-EE-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 2197088.75
EU funding (EUR): 2197088.75
Participants: 8
Project status: SIGNED

The detailed knowledge of building stock features and performances has a potential positive disruptive effect on the ability of the EC to design effective policies targeting buildings in view of the 2050 strategy and the European Green Deal. Given the lack of comprehensive and reliable data on the EU building stock, BuiltHub will develop a structured and inclusive data collection approach, as well as an easy to access & use datahub, in the shape of a structured web-based platform (IT infrastructure, analytics and user-friendly dashboard), which will be fed into thanks to a benefits-based engagement strategy targeted to data and metadata providers, as well as simple users. The mentioned benefits-based engagement strategy will be implemented by developing added value information services tailored to lead-users of the platform and other main beneficiaries (end-users). The main premise behind the BuiltHub community building proposal is that data owners will be willing to feed-in data/information to the BuiltHub platform, in exchange for the added value information/knowledge that will be put out by the platform through its operation. In addition, “multipliers” will disseminate the BuiltHub achievements for enlarging the related community. The BuiltHub consortium will also develop different data processes and service schemes to cover possible users, based on their needs and potential use of data & analytics, as well as the benefits they could enjoy from cooperating with BuiltHub. The project aims to build upon the building stock observatory database and related analytics for making the data flow easier, resilient and safe. However, the BuiltHub consortium is also ready for a development approach which stands on its own, as a back-up plan. It also aims to work in close collaboration with mirror and sister projects and in particular B4E-6 MATRYCS by sharing data collection approach and a standard definition of each elements at different level (country to single building).

Keywords: long lasting building data flow,engaged building stakeholders benefits,building stock analysis,agile web based building knowledge platform
Catchments under Pressure: Ecosystem Service Solutions (CuPESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Catchments are under pressure from impacts on demand and supply and within these constraints water resource managers are challenged to meet multiple and often competing values. The ecosystem services (ES) approach has attracted policy interest as it connects natural capital and the ES flows it supports with human wellbeing. There exists a policy window to translate detailed case study assessment into workable solutions for catchment management in times of change in Europe and beyond. ES research to protect and foster sustainable management of natural resources and ecosystems and the multiple ES they supply fits within the Horizon 2020 programme on Societal Challenges. The U.K. is emerging as a world leader in applying the ES approach to inform and improve natural capital planning and management in land and water resources management practice. The proposed interdisciplinary research would align with these initiatives to examine pragmatic planning solutions adopted in U.K. Water Framework Directive River Basin Districts. The objective of ‘Catchments under Pressure: ES Solutions’ (CuPESS) is to understand how catchment managers are using the ES approach to provide local, adaptive and integrative management solutions in flood prone catchments and what are the opportunities and barriers to wider adoption. This Individual Fellowship will provide opportunity for knowledge exchange, with the fellow returning to Europe and bringing her research expertise on the the ES approach and its use in water resources management in the U.S. and Australia. It will also allow the fellow to build on this research experience in an interdisciplinary research environment, to learn from a new context which will contribute to greater understanding of land-water interconnections, ES innovations and implementation strategies that work in practice. Lessons generated will be of wider relevance for flood risk management in other northern European countries and beyond.

Keywords: ecosystem services approach,water planning,water management,comparative analysis,interdisciplinary research
Atomic Gauge and Entanglement Theories (AGEnTh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-05-01
End date: 2023-04-30
Duration (months): 60.0
Total project cost (EUR): 1055317.0
EU funding (EUR): 1055317.0
Participants: 1
Project status: CLOSED

AGEnTh is an interdisciplinary proposal which aims at theoretically investigating atomic many-body systems (cold atoms and trapped ions) in close connection to concepts from quantum information, condensed matter, and high energy physics. The main goals of this programme are to: I) find to scalable schemes for the measurements of entanglement properties, and in particular entanglement spectra, by proposing a shifting paradigm to access entanglement focused on entanglement Hamiltonians and field theories instead of probing density matrices; II) show how atomic gauge theories (including dynamical gauge fields) are ideal candidates for the realization of long-sought, highly-entangled states of matter, in particular topological superconductors supporting parafermion edge modes, and novel classes of quantum spin liquids emerging from clustering; III) develop new implementation strategies for the realization of gauge symmetries of paramount importance, such as discrete and SU(N)xSU(2)xU(1) groups, and establish a theoretical framework for the understanding of atomic physics experiments within the light-from-chaos scenario pioneered in particle physics. These objectives are at the cutting-edge of fundamental science, and represent a coherent effort aimed at underpinning unprecedented regimes of strongly interacting quantum matter by addressing the basic aspects of probing, many-body physics, and implementations. The results are expected to (i) build up and establish qualitatively new synergies between the aforementioned communities, and (ii) stimulate an intense theoretical and experimental activity focused on both entanglement and atomic gauge theories. In order to achieve those, AGEnTh builds: (1) on my background working at the interface between atomic physics and quantum optics from one side, and many-body theory on the other, and (2) on exploratory studies which I carried out to mitigate the conceptual risks associated with its high-risk/high-gain goals.

Keywords: topological matter,low dimensional systems,gauge theories
Opening Synchrotron Light for Experimental Science and Applications in the Middle East (OPEN SESAME)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Germany,Italy,Italy,Cyprus,Switzerland,Jordan,France,France,France,United Kingdom
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 2100823.75
EU funding (EUR): 1957323.75
Participants: 11
Project status: CLOSED

The OPEN SESAME project will ensure optimal exploitation of the Synchrotron light for Experimental Science and Applications in the Middle East (SESAME) light source. With this aim, OPEN SESAME has three key objectives: 1. To train SESAME staff in the storage ring and beamline instrumentation technology, research techniques and administration for optimal use of a modern light source facility. 2. To build-up human capacity in Middle East researchers to optimally exploit SESAME’s infrastructure. 3. To train SESAME staff and its user community in public outreach and corporate communications, and to support SESAME and its stakeholders in building awareness and demonstrating its socio-economic impact to assure longer term exploitation. Each objective is tackled by a work package. Firstly, SESAME staff training is addressed by 65 staff exchanges planned between SESAME and the European partners. Secondly, capacity-building is targeted by five training schools, a short-term fellowship programme and an industrial workshop. Finally, a proactive communications strategy will be created, including an educational “roadshow” to all of the SESAME Members, and a training programme in research infrastructure administration and their economic role and impact for young science managers of SESAME Member stakeholders. The project directly addresses the INFRASUPP-2016-2017 call to support SESAME. OPEN SESAME is well aligned to the broader scope of the work programme with activities that will have a lasting impact on a reinforced European Research Area, and particularly in strengthening international cooperation for research infrastructures with a key Region located close to Europe. The project has been developed closely with SESAME, its Directors and international Training Advisory Committee. The OPEN SESAME consortium is composed of ten European institutes (six light sources, The Cyprus Institute, CERN, CNRS and Instruct) along with SESAME itself.

Keywords: training,staff exchange,environmental science,cultural heritage,life sciences,structural biology,outreach,public awareness,stakeholder awareness
Modelling Nonlinear Aerodynamics of Lifting Surfaces (MONNALISA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,France
Call: Development and validation of a method to predict non-linear aerodynamic characteristics of lifting surfaces with controls (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-03-31
Duration (months): 27.0
Total project cost (EUR): 1001267.5
EU funding (EUR): 895130.0
Participants: 3
Project status: SIGNED

The performance-improvement objectives sought in the Clean Sky 2 Joint Undertaking requires a departure from conventional empennage configurations and technologies that constitute the current state of the art in aircraft design. An “Advanced Rear End” component for the forthcoming generation of ultra-efficient aircraft might consist of a very compact rear fuselage and tail surfaces with planforms significantly different from those currently used in terms of aspect ratio, taper ratio and sweep angle. In this project, we aim at developing and validating an innovative, physics-based low-order method to predict the non-linear aerodynamic characteristics of lifting surfaces with controls whose geometry could significantly differ from the usual ones. The development and validation of the method relies on a high-resolution database scanning the extensive space of design parameters required in the call: sweep angle, aspect ratio, taper ratio, dihedral angle, shape of the leading edge and presence of ice. A recently validated approach, based on the most advanced techniques of uncertainty quantification, guarantees the reliability of the database of the aerodynamic characteristics that will drive the development of the method. The aerodynamic database will efficiently mix highly accurate experimental results with state-of-the-art, high-fidelity numerical simulations and lower fidelity simulations. The success of the project is guaranteed by the scientific quality and reliability of the partners in the consortium that have extensive experience in aerospace research projects, by state-of-the-art experimental facilities and aerodynamic-simulation open-source codes, and by a judicious use of subcontracting.

Keywords: advanced rear end,low oerder modelling,uncertainty quantification,wind tunnel testing
Therapeutic hijacking of E3 Ligases (Glue2Degrade)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1331340.0
EU funding (EUR): 1331340.0
Participants: 1
Project status: SIGNED

Traditional drug design relies on inhibition of enzymes or receptors with accessible hydrophobic pockets. The concept of proteolysis targeting chimeras (PROTACs) promised to overcome this limitation. Following our discovery of the first PROTAC that induced selective protein degradation in vivo, this technology has seen a boost in academia and industry. Despite global research efforts, advances are so far incremental: (i) most focus is on degrading targets that can be liganded and are druggable with conventional inhibitors; (ii) currently, only 3 out of 600 E3 ligases can be exploited. Glue2Degrade aims to transform the pharmacologically targetable space of the proteome. The project is built on the hypothesis that molecular glues (MGs), non-chimeric small molecules that degrade target proteins by inducing cooperative binding to E3 ligases, are much more prevalent than anticipated. Lenalidomide and related immunomodulatory drugs (IMiDs) are prime examples of the potential of MGs. Without a specific targeting moiety, IMiDs induce cooperative binding of the E3 ligase CRBN to undruggable proteins like IKZF1/3, thereby inducing their degradation. However, no technologies exist to rationally develop MGs that hijack other E3 ligases. ERC-funding would allow us to address this limitation. Based on data generated in my laboratory, we will systematically identify novel MGs and their E3 ligases by innovating (i) phenotypic discovery strategies, and (ii) an orthogonal chemical genetics pipeline. To elucidate the mechanisms of novel MGs, we will (iii) conduct target identification via unbiased proteomics followed by (iv) chemical optimization and initial translational characterization. Glue2Degrade, if successful, will transform the engageable E3 space and identify novel MGs, thereby opening up the potential for therapeutic development of cell-, tissue-, and cancer-type specific chemical degraders for undruggable proteins.

Keywords: protein degradation,molecular glues,chemical biology,undruggable proteins,chemical genetics,e3 ligases
Nano Engineered Injectable Biomaterials for Osteoporotic Bone Treatment (NanoBOOST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: SIGNED

My aim as an MSCA Individual Fellow is to tackle a devastating clinical orthopaedic challenge for which there is currently no reparative treatment, specifically osteoporotic vertebral fractures (OVFs), by developing an advanced biomaterial technology to restore structural integrity and function of disease-damaged bone. The scientific goal of this proposal is to develop a novel therapeutic injectable nanomaterial technology for OVFs repair. This will be achieved through an innovative research project that aims to implement a transformative strategy utilising antioxidant-ion substituted nano-particles (a-NPs) to target disease impaired osteoblast function and drive bone regeneration. In addition, an innovative biomaterial strategy will be employed, combining mechanically robust nano-silicates with a bioresorbable collagen matrix for local controlled release of therapeutic a-NPs, as a pioneering advance for OVFs treatment. As an ambitious postdoctoral fellow, the training objective of this fellowship is to attain the requisite scientific and complementary skills to successfully achieve my long-term goal of establishing an independent research programme that will contribute to Europe’s research & innovation capacity and reputation. This will be achieved through the expert supervision and input of Dr Ciara Murphy (Royal College of Surgeons in Ireland –RCSI), her colleagues in RCSI and collaborative research centre AMBER, and through research secondment with Prof Boccaccini (Friedrich-Alexander Universität Erlangen-Nürnberg). In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management and dissemination. I will also avail of opportunities to supervise students in related projects. In summary, this Fellowship will provide invaluable help to establish an independent research niche in regenerative biomaterial development, while equipping me with the skills needed to embark on my independent research career.

Keywords: bone regeneration,antioxidant nanoparticles,collagen hydrogels,osteoporotic vertebral fractures