Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revolutionary HE3DA battery technology boasts an unmatched safety, longer lifespan and recyclability, revolutionizing the energy storage industry and driving the future of sustainable energetics. (MES a.s.)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 99.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Magna Energy Storage a.s. (MES), established in the Czech Republic in 2017, is poised to revolutionize the energy storage industry with its proprietary HE3DA® nano-technology. The ambition is to construct a state-of-the-art production facility dedicated to high-capacity, sustainable battery solutions. The innovative HE3DA battery design transcends the limitations of traditional lithium-ion systems, providing enhanced safety, extended operational lifespan, and complete recyclability, reflecting a commitment to environmental stewardship and technological advancement. HE3DA technology stands at the forefront of the energy sector, achieving a synergy between advanced nanomaterial properties and optimized electrode morphology. The adaptability of electrode thickness allows for customizable battery capacity and charge-discharge rates, offering a versatile solution to a variety of energy storage needs. Furthermore, material selection flexibility supports a transition towards alternative, non-lithium chemistries. With a portfolio of 128 principal patents, HE3DA solidifies its leadership in the battery domain. Holding all critical patents within a European entity underscores MES's strategic autonomy and its contribution to the EU's economic landscape. MES's exclusive production license in Europe is a testament to its potential to deliver cutting-edge energy solutions while fostering regional development. As a candidate for Horizon Accelerator funding, MES demonstrates a profound capacity to address some of the most pressing challenges in energy storage. The HE3DA® technology aligns with the European Green Deal, promising to enhance the integration of renewable energy sources and bolster the EU's transition towards a resilient and sustainable energy ecosystem. The proposed project not only exhibits robust commercial viability but also embodies the transformative impact essential for Horizon Europe's mission to stimulate industrial leadership and innovation excellence.

Keywords: battery,battery storage,energy storage,stationary battery storage,energetics,res,renewable energy,renewables,sustainability,circularity,circular economy,safety,solar energy,wind energy
Digitisation of cultural heritage of minority communities for equity and renewed engagement (DIGICHer)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Lithuania,Netherlands,Germany,Finland,Italy,Belgium,Austria
Call: Re-visiting the digitisation of cultural heritage: What, how and why? (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 3899812.5
EU funding (EUR): 3899812.5
Participants: 11
Project status: SIGNED

Cultural heritage (CH) digitisation brought great opportunities to preserve, maintain and promote it. Yet, it also triggers challenges in terms of representation and content exhibition. This becomes particularly pressing in the context of CH of minorities. Overall, this reduces participation and inclusion of minorities, hindering equitable representations of diverse values in digitisation, leading to increased risks of misuse of digital CH. DIGICHer tackles these challenges by providing new understanding on key legal and policy, socio-economic and technological factors governing digitisation of minorities’ CH. Following the citizen science and co-creation approach DIGICHer develops a novel scalable framework and methods to promote equitable, diverse and inclusive practices, verified via user-centric approaches through pilots with three minority groups in the EU: the Sámi, the Jewish and the Ladin people with a further exploitation in other minorities groups. On these bases, it develops recommendations for policy and decision makers, as well as CH institutions, and delivers methods for decision support to monitor the field of digital heritage with specific regards to its diversity long-term. The DIGICHer interdisciplinary consortium will lead to several actions and outcomes that will increase minorities’ involvement in the digitisation and usage of their CH, contributing to a more responsive and democratic cultural sector, whose digital activities reflect the plurality of minorities’ worldviews in Europe. Minority heritage will be represented in a way which respects minorities’ values, ensuring better understanding and enhanced engagement with minority heritage collections by the general public and professional heritage users, leading to more resilient European cultural institutions with a pluralistic offer that is appealing to a diverse future generation of audiences.

Keywords: digitisation,cultural heritage,minority groups,indigenous minorities,engagement,digital heritage,citizen science,intangible
Enhancing the Potential of Enzymatic Catalysis with Light (PHOTOZYME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2945000.0
EU funding (EUR): 2945000.0
Participants: 1
Project status: SIGNED

One pressing challenge of chemical research is to develop new processes that responsibly use natural resources to produce added-value chiral molecules. PHOTOZYME seeks to provide solutions by combining photocatalysis, biocatalysis, and organocatalysis. These three modern strategies offer powerful tools for the sustainable preparation of chiral molecules. To date, however, they have remained largely unconnected. This proposal aims to bridge these fields in order to address major problems in asymmetric synthesis for which there is no general solution with established methods. Specifically, we will focus on native organocatalytic intermediates formed in the enzymes’ active sites, exploring their potential ability to reach an excited state upon visible light absorption and thus enable new-to-nature radical reactions. Here, light will be used to program entirely new mechanisms of catalysis within enzymes with an established ground-state reactivity, thus allowing them to catalyse completely different processes than those for which they evolved. The resulting photoenzymes will be powered by absorption of photons at each catalytic cycle and will serve to infer high enantioselectivity in important radical chemistries. Our artificial photoenzymes will be applied in four “challenge areas”, each representing crucial yet unsolved synthetic problems. We will develop methods to convert simple feedstock chemicals (e.g. fatty acids) into chiral building blocks. Additionally, our goal is to control the formation of multiple stereocentres in intermolecular radical processes and at remote positions of linear substrates, objectives that are exceptionally difficult to achieve with existing small-molecule systems. We also envision the design of biocatalytic radical cascades for the rapid synthesis of biorelevant chiral scaffolds directly from abundant substrates. Overall, we aim to provide new photobiocatalytic tools that drive the sustainable production of chiral molecules.

Keywords: asymmetric catalysis radical chemistry enzymatic catalysis photocatalysis organocatalysis
Curing ovarian cancer through autoantibody-based therapy (OVCure)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-08-01
End date: 2026-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Ovarian cancer (OC) is a malignant tumor with poor prognosis and limited treatment options, responsible for 4.4% of cancer-related mortality in women. There is an urgent need for innovative therapeutic approaches for OC. Antibody drug conjugates (ADCs) represent one of the most promising therapeutic approaches, but their efficacy has been hindered by identification of suitable tumor-associated antigens. For example, ADCs targeting MUC16, the best diagnostic marker for OC, have thus far failed in clinical trials due to shedding of MUC16 from the tumor. Our breakthrough lies in the identification and characterization of a MUC16-specific autoantibody clone – 2B5, which specifically targets the non-shed and highly conserved epitope of MUC16 that stays associated with the tumor. This consequently, dramatically increases the efficacy of the cytotoxic payload delivery to the tumor, and overcomes limitations of similar ADCs that have failed in the past. By directly and selectively targeting MUC16 on OC, while sparing healthy tissues, our ADC has the potential to revolutionize OC therapy by finally offering a precise and effective ADC cancer treatment. Thus, for this PoC, we aim to demonstrate the effectivity of our 2B5-based ADC, as a leading candidate for OC therapy in humans. In order to increase its therapeutic and commercial potential, the 2B5-based ADC will be developed further to identify the most suitable payload, as well as to validate its tumor killing efficacy in pre-clinical animal models, which will be developed in frame of this project. By the end of this PoC, we aim to be ready to develop our 2B5-ADC to human grade towards phase 1 clinical trials. Simultaneously, we will define the innovation commercial feasibility and business model and will validate the business opportunities and go-to-market strategies with relevant stakeholders. Furthermore, we have already initiated the process of patenting our innovation and aim to finalize it during the PoC.
Information-based Strategies for LAND Remediation (ISLANDR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Finland,France,Netherlands,Greece,Sweden,Portugal,Italy,Poland,Belgium,Kosovo,Switzerland,United Kingdom
Call: Remediation strategies, methods and financial models for decontamination and reuse of land in urban and rural areas (HORIZON-MISS-2022-SOIL-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 5804677.75
EU funding (EUR): 5804677.5
Participants: 15
Project status: SIGNED

The Information-based Strategies for LAND Remediation (ISLANDR) project is cross-disciplinary and multi-actor and aims to promote the delivery of Green Deal objectives, in particular achieving Zero Pollution by reducing soil pollution and enhancing restoration. ISLANDR will provide a series of tools and methods to support: (1) the delineation of soil pollution sources, (2) the assessment of risks, (3) the implementation of sustainable and risk-based land management (SRBLM), (4) the inclusion of wider valuation approach in financial and investment cases, (5) closer integration of land contamination and spatial planning decision-making and (6) key policy relevant findings related to the Soil Strategy, proposed soil health law and other areas of policy where soil is a crucial consideration. ISLANDR takes a carefully targeted approach in view of the large existing knowledge base, and has designed its outcomes be easily assimilated by multiple target groups (incl: policy interests, planners and regulators, site managers and their service providers). Care is taken to ensure support for capacity building and also to service the needs of long term repositories (e.g EUSO). Innovations include using CBA to provide robust valuation for parallel benefits to improve business cases; a technical basis for soil functionality as a “soil health” receptor, and operating window analyses of NBS and other low input remediation. ISLANDR makes use of 7 test areas across Europe to provide real world research context and road-test findings, including areas impacted by green transition consequences. Roundtables in these areas provide active local stakeholder dialogue and a basis for rapid implementation and new project roll-out. A key focus of ISLANDR is to facilitate soil remediation in situations where the case is economically marginal or negative, by providing a more thorough understanding of low input approaches and a wider value proposition for investment cases and financial planning.

Keywords: information based strategies,sustainable and risk based land management,assessment of costs and benefits,
Systemic delivery of oncolytic herpes simplex viruses retargeted to cancer-specific receptors. Virus optimization and business planning. (Syst-Onco-Herpes)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Solid tumors, in particular metastatic ones, represent unmet clinical needs and the second cause of death worldwide. Oncolytic viruses (OVs) kill tumors and spare normal cells. They are a distinct class of novel anti-cancer agents, frequently administered by intratumoral injection. A Holy Grail in the innovation of OVs is the possibility to administer them by systemic, e.g. intravenous injection, so that in the human body OVs search for metastases and scavenge them. The systemic delivery of OVs tackles societal challenges as it meets the needs of metastatic patients, those who die of cancer and need innovative therapies most. The Principal Investigator has generated a family of innovative oncolytic herpesviruses (ReHVs) which specifically target HER2-positive tumors (HER2-ReHVs). In preclinical studies HER2-ReHVs exhibit high specificity for HER2-positive cancers, high anti-tumor efficacy also against metastatic tumors, vaccinate against metastatic-like tumors, and are highly safe. These properties position ReHVs for systemic delivery. The ReHV technology is protected by a portfolio of patents. The objectives of this Proposal are twofold. Firstly, to improve the systemic delivery of ReHVs by identifying the obstacles that constrain such administration, to develop novel strategies to overcome them, including high-risk high-gain modifications that make ReHVs better suited for the systemic delivery. Secondly, to carry out initiatives for the technological transfer, i.e. development and commercialization of ReHVs. These include the detailed planning of activities to take ReHVs to the authorization for a First-in-Human clinical experimentation, to develop a business plan and carry out OV market analysis and search for investors. By combining the Development and commercialization initiatives with the technological advancements, this POC is expected to achieve the broader objective of progressing ReHVs into clinical experimentation and ultimately to bring them to patients
ENHANCING NON-COMMUNICABLE DISEASE RESEARCH EXCELLENCE THROUGH ZEBRAFISH CAPACITY BUILDING (ZeNCure)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Serbia,Germany,Portugal,Latvia,United Kingdom
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1307275.0
EU funding (EUR): 1307275.0
Participants: 5
Project status: SIGNED

ZeNCure aims to foster collaborative research and enhance scientific excellence at the Institute of Molecular Genetics and Genetic Engineering, University of Belgrade (IMGGE) in Serbia. This ambitious initiative brings together IMGGE with world-renowned research institutions in Germany (MPG), Portugal (CF) and the United Kingdom (UoS) along with an associated partner from Latvia (BGI RFL). The overarching goal is to elevate IMGGE's research profile by strengthening its capabilities in zebrafish (ZF) research, particularly in the context of non-communicable diseases (NCDs). NCDs pose a significant global health challenge, accounting for over 74% of all deaths worldwide. These diseases are influenced by a complex interplay of genetic, physiological, environmental, and behavioral factors. Recognizing the gravity of the situation, the EU has prioritized NCD research under the Cluster 1: Health of Horizon Europe. ZeNCure focuses on the critical role of in vivo models in NCD research, ranging from identifying genetic and environmental risk factors to testing innovative therapeutics. It leverages cutting-edge technologies, including next-generation sequencing (NGS) and bioinformatics, to enhance IMGGE's capabilities in this field. ZeNCure is poised to accelerate the professional development of both early-stage and senior researchers, as well as administrative staff. This holistic approach will not only enhance IMGGE's competitiveness in European research funding schemes but also create an inspiring and supportive research environment. ZeNCure represents a transformative endeavor that aims to strengthen scientific collaboration, improve research capabilities, and contribute to the global fight against NCDs. By bridging the gap between IMGGE and leading European research institutions, the project aspires to elevate IMGGE into a competitive and internationally recognized research institution in the Western Balkans, fostering regional integration and convergence with the EU.

Keywords: capacity building,project administration,research management,transgenic zebrafish lines,transgenerational studies,zebrafish xenograft model,non communicable diseases,bioinformatics
Advanced moDelling of MEMS In Routine and Extreme (ADMIRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-15
End date: 2027-07-14
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

Key sensors for advanced and everyday technology, such as smartphones and drones, rely on inertial micro-electro-mechanical systems (MEMS). In some extreme applications they cannot yet be used, in others they cannot be substituted upon failure. Contrarily, in consumer applications they are not exploited to the end of life, in a wasteful planned obsolescence cycle. Advanced moDelling of MEMS In Routine and Extreme (ADMIRE) plans to tackle both problems by disrupting the current design practice that relies on empirical approaches based on phenomenological material properties. ADMIRE proposes a multiscale modelling framework rooted in atomistic simulations, which are cleverly extrapolated to the microscale and interpreted using Machine Learning, all to predict material degradation under a wide range of operating conditions. The result will be a new class of smart constitutive laws that will seamlessly integrate in continuum models to quantify the degradation of MEMS during prolonged use or extreme loads. A key advantage is that the effect of defects, microstructure and loads becomes transparent and mechanistic predictions become possible. Materials, engineering and computer sciences are tightly intertwined in this challenging framework. Its probability of success is maximised by reflecting the same mix in the research team and by teaming up with a world leader company in MEMS technology. Impacts will propagate to society, supporting the eco-efficient reusability paradigm, to technology, opening new applications for MEMS, to economic growth, boosting the strategic market of advanced sensors that is already on the rise, and to the leadership of Europe in this competitive field.

Keywords: atomistic simulations,multiscale modelling,machine learning,mems