Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coping with decline: Comparative social-historical analysis of depopulation and community welfare in Europe, 1950-2022 (DEPOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1496854.0
EU funding (EUR): 1496854.0
Participants: 1
Project status: SIGNED

The shrinking population and closure of schools and hospitals are among the main signs of regional depopulation. Although this phenomenon has been widespread in Europe since the 1950s, affecting both rural and urban communities, historical studies of depopulation are still scarce. How communities have responded, and indeed coped, with the decline in population and welfare over the past 70 years is uncharted territory. DEPOP will break new ground by illuminating regional depopulation as a potent example of a slow burn crisis, occurring over extended periods of time. We will: map out demographic trajectories of depopulation and their links to welfare provision; investigate community strategies to cope with depopulation; and develop a new framework to study community welfare in the slow burn crises as depopulation. Slow burn crises occur over extended periods and may thus be less visible than one-time shocks and disasters. There is currently no approach to examine how communities cope with slow burn crises. DEPOP will develop a novel multi-level approach by drawing on and developing methodologies in compositional demography, which is rooted in the historical concept of communication communities. DEPOP will look at communities in depopulating regions in Finland, the Netherlands, and Ukraine. We will analyse: (macro-level) population trajectories and state welfare provision data, available as reports and regional statistics; (meso-level) collective coping strategies through social organisations, collected through their archives and witness seminars, and (micro-level) individual coping strategies, examined through oral histories. DEPOP’s historical approach and findings will offer the first-of-its-kind comparative framework to study communities affected by the slow burn crisis of depopulation. This will help us to advance our understanding of why some communities have historically been more resilient than others when faced with slow burn crises.

Keywords: regional depopulation,decline,welfare,social history,comparative history,communities,slow burn crises,lived experiences,oral history,social organisations,state,kin,gender,age,finland,the netherlands,ukraine
Tracking the Intestinal Permeation and Circulation Effects of Environmental MicroPlastics (TRACE-MP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 292073.4
EU funding (EUR): 292073.4
Participants: 2
Project status: SIGNED

Plastic pollution poses a significant threat to human health, particularly through the infiltration of microplastics (MPs) into the body. Emerging studies have detected MPs in various organs, with food and drinking water identified as major sources of exposure. While clinical studies suggest potential links between MPs and conditions such as thrombosis, liver cirrhosis, and endometriosis, a critical gap remains in understanding how the physicochemical properties of MPs, altered by environmental weathering, influence their ability to permeate biological barriers like the intestinal lining—a key gateway to systemic exposure. The TRACE-MP project (Tracking the Penetration and Circulation Effects of Environmental MicroPlastics) addresses this gap by investigating how environmentally relevant MPs, specifically those prepared by artificial weathering and with bio-coronas (BC) formed through interactions with proteins and lipids in the gastrointestinal tract and blood, permeate the intestinal barrier and induce vascular endothelial leakiness. This research will utilise advanced in vitro models, including static and dynamic systems, to simulate realistic biological conditions. The project’s objectives include: (1) characterising bio-coronas on MPs in the gastrointestinal and blood environments, (2) evaluating the permeation of MPs-BC complexes through the intestinal barrier, (3) assessing their potential to induce endothelial leakiness, and (4) correlating these findings with the physicochemical properties of MPs to perform a comprehensive risk assessment. By advancing our understanding of the mechanisms underlying MPs' systemic distribution and impact on human health, TRACE-MP will inform regulatory policies and mitigation strategies to protect public health from plastic pollution. This interdisciplinary approach, combining chemistry, toxicology, and medical biology, is timely and crucial given the growing evidence of MPs in human tissues and their potential health risks.

Keywords: microplastic,toxicology,intestinal barrier,endothelial leakiness,biocorona,artificial weathering,environmental toxicology,plastic pollution
The GEne Therapy INnovation Training Network (GET-IN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Germany,France,Italy,Greece,Netherlands,United States,United Kingdom
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2938363.71
EU funding (EUR): 2615796.0
Participants: 15
Project status: SIGNED

Gene therapy has transitioned from a distant hope to reality. To date 3 rAAV gene therapies are approved in the EU, >30 phase III clinical trials ongoing, and exciting developments in therapeutic gene editing in the pipeline. However, fundamental limitations in the bioprocessing of gene therapy vectors limit broader application. Manufacturing is not automated, with an open process environment, limited scalability and robustness, and inefficient downstream processing, resulting in huge footprint and exceedingly high cost of goods. The field requires scalable manufacturing technology with modular design to produce high doses for large patient groups at a fraction of cost. Improved delivery approaches with increased specificity and efficacy at lower doses are needed to overcome emerging safety concerns observed in clinical trials. Prediction of therapeutic efficacy in man is challenging due to a species barrier, underlining the need for humanized models to reduce attrition rates in the development pipeline. To overcome these challenges, innovation driven by multidisciplinary approaches is direly needed. GET-IN is a doctoral network of 7 academic and 8 non-academic partners, with expertise in vectorology, genome editing, process engineering, biomanufacturing and innovative humanized models. Together, they provide an excellent training framework for 10 Doctoral Candidates (DCs) who will be the future innovators in the gene therapy field. Research in GET-IN will investigate disruptive innovations including optimised bioprocessing, digital simulation, novel and improved vectors and genome editors, targeted delivery systems, and human organ-on-chip models for more relevant safety and efficacy evaluation. The joint training programme will emphasise responsible, cooperative research and innovation, creativity, and entrepreneurship to maximize the career potential of the DCs.

Keywords: genome editing,raav,virus like particles,viral vector production,producer cell lines,process optimization,digital twin,crispr cas9,targeted delivery,humanized organ on chip models
Regenerative engineering innovation in early intervention of osteoarthritis (RENOVATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Portugal,United Kingdom,Italy,Romania,Poland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 2881646.64
EU funding (EUR): 2881646.64
Participants: 11
Project status: SIGNED

Recent breakthroughs in tissue engineering are helping to overcome some severe limitations of osteoarthritis (OA) treatment strategies. Although the latest advances to regenerate cartilage lesions to a healthier state have opened a promising way to prevent joint replacement, current solutions still have a number of challenges ahead to effectively promote satisfactory durable regeneration along the disease progression. With these perspectives, the biomedical engineering market is rapidly growing and demands new knowledge, new skills and new approaches to adapt to the technological evolution of the sector while providing robust products, solutions and treatment strategies which only find a partial match in existing doctoral programmes. RENOVATE addresses this challenge by delivering an innovative multinational, multi sectoral, and multidisciplinary research and training programme in new technologies and novel strategies to produce a new generation of multi-material graded osteochondral scaffolds with a focus on large OC defects. From the research point of view, RENOVATE will integrate data and knowledge to: 1) define patient-specific key functional and mechanical requirements for large osteochondral scaffolds and deliver new therapeutic schemes; 2) enhance the physicochemical and biological behaviour and the mechanical fixation scaffolds; and 3) produce Functionally Graded large osteochondral scaffolds evolving existing 3D printing equipment. With this purpose, RENOVATE’s partnership aggregates relevant scientists from the academic and clinical worlds that will be involved in a high-level personalised training programme that will guarantee fellows and future PhD students outstanding Career Opportunities in the biomedical engineering, orthopaedic sectors and beyond. RENOVATE will disseminate results to a wide spectrum of stakeholders, create awareness in the general public about OA and encourage vocational careers among students.

Keywords: scaffolds,additive manufacturing,tissue engineering,biomaterials,osteoarthritis
Ecosystemic Resilience against Platformization (ERAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Digital platforms can massively erode the social environment in which they operate. For instance, short-term rental platforms (STRs) such as Airbnb dislodge vulnerable locals from their homes, escalate gentrification, and further fuel overtourism. Urban ecosystems develop organized responses to such disruptions ranging from local social movements to international city alliances, which take action to address extensive ‘platformization’. While the knowledge of the systemic effects of the ‘platformization’ of society is increasing, we still know little about the emergent resilient responses and the further effects they set in gear. This project titled "Ecosystem Resilience against Platformization" (ERAP) fills the gap by exploring and theorizing the efforts to counter the negative effects caused by STRs. ERAP employs case study methodology to zoom in on four EU cities where the negative effects of STRs are particularly visible, but the responses are vastly different. The fieldwork focuses especially on giving voice to and learning from underprivileged groups, e.g., tenants at risk of losing housing and housing movements. Complementing that is a longitudinal study tracking the efforts to establish EU-wide STR regulations. Leveraging the novel interdisciplinary field of digital ecology, ERAP will trace patterns of ecosystemic intensifications (e.g., the loss of affordable housing) and the emergent organised resilient responses. The analytical emphasis will be on the configurations of social actors mobilised in those processes, their tactics, the use of digital technology, and interconnections (e.g., alliances), with the goal of explaining the systemic dynamics of digital resilience. ERAP will contribute to the growing field of digital ecology and inform EU's policy on next-generation sustainable digitalisation, emphasising that the future of digitalization is negotiated among a broad range of stakeholders and across levels (from local to transnational).

Keywords: digital ecosystem ecosystemic resilience digital platform social mobilisation digital short term rentals overtourism digital ecology
From Hodge theory to combinatorics and geometry (HodgeGeoComb)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France,Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1948125.0
EU funding (EUR): 1948125.0
Participants: 3
Project status: SIGNED

We propose an approach to the Dodziuk-Singer conjecture, a central conjecture in geometric topology, specifically concerning the great challenge that understanding aspherical manifolds can pose, based on newly developed tools from combinatorial commutative algebra and combinatorial Hodge Theory, and discuss several intermediate problems along the way. The main idea is based on a connection to commutative algebra via the partition complex, an interpretation of local cohomology that allows for a translation between data contained in the L2 cohomology of a manifold and Lefschetz properties of toric varieties associated to them. Additionally, we outline connections to other approaches to the Dodziuk-Singer conjecture as well as special cases, such as the Hopf and Charney-Davis conjectures, and propose ideas to connect the different aspects of the viewpoints into one. Finally, we discuss problems related to the methods proposed, in particular focussing on unrealised and unexploited relations between combinatorics, Hodge theory and geometry. We discuss in particular deformations of polyhedra and metrics, as well as expansion and connectivity.
Seeing Waste Like a City: Towards Just Circular Economies in Glasgow and Mexico City (URBANWASTE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Mexico
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

This 2-year project combines innovation in urban theory with comparative research on two cities to advance knowledge on how circular economy and urban waste policy can be made more effective and just. Increasing municipal solid waste is leading to mounting environmental and social risks, especially in urban areas. Local governments are urgently trying to reduce waste generation, notably through the model of the circular economy. Yet, so far, policies have failed to achieve sustainable change in urban economies because the circular economy overlooks the multiple entanglements of waste within urbanites’ everyday lives and its embeddedness in the uneven global economy. In short, the decidedly urban nature of waste is neglected in circular economy initiatives. URBANWASTE will therefore see waste like a city, to demonstrate how waste is generated, handled and potentially reduced in the multiple processes and places of urban collective life as they interconnect with supralocal political-economic processes. Through an original blend of qualitative methods and approaches in urban political theory, urban political ecology and urban political economy, it will conduct studies of waste in Glasgow and Mexico City and place these in a global-comparativist frame. The project will build on the researcher’s research expertise and language skills to advance her theoretical and methodological skills in new empirical contexts. This will contribute to her ambition of becoming an expert in urban and sustainability studies. She will benefit greatly from two leading urban scholars: the main supervisor, Dr Beveridge, who will host her at the University of Glasgow, and the secondment supervisor, Dr Boudreau, who will support a 5-months secondment at the National Autonomous University of Mexico during the fieldwork in Mexico City. The project will produce novel insights in theory and practice to advance debates on circular urban waste policy in Europe and globally.

Keywords: urban politics,urban waste,urban political ecology,global urban comparativism,circular economy
Digital Discovery Platform for Organic Electronics Materials (DiaDEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Hungary,Germany,United Kingdom
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-05-01
End date: 2025-04-30
Duration (months): 36.0
Total project cost (EUR): 1294000.0
EU funding (EUR): 1294000.0
Participants: 3
Project status: CLOSED

We propose to develop and commercialize a digital platform to accelerate the discovery and deployment of molecular materials in the broad sector of organic and printed electronics. This sector, with enormous market potential, is limited by the slow and inefficient development of new materials. Using this platform, functional materials for a specific purpose are discovered through virtual screening with predictions benchmarked against a continuously growing number of experimental data. The technology samples the space of all molecules that are commercially available and their synthetically feasible analogues. The platform provides a one-stop-shop solution from digital discovery to experimental verification by linking the candidates identified via virtual screening with the chemical supply chain and the procurement of such candidates. The size of the chemical space explored, the validation of screening methods against experiments and the link with the supply chain are all unprecedented in organic electronics. This project is brought together by the University of Liverpool, who developed the database and the underlying validation methodology, NANOMATCH, provider of modelling solutions to the organic electronics sector, and MCULE, aggregating one of the largest purchasable chemical spaces for organic compounds

Keywords: industry 4 0 virtual screening device physics
Circular BIOeconomy TRANSFORMation for regions by enabling resource and governance networks (BIOTRANSFORM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Coordination and support actions
Countries involved: Luxembourg,Belgium,Spain,Greece,Germany,Czechia,Finland
Call: Benefits of the transition towards sustainable circular bio-based systems from linear fossil-based (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-10-01
End date: 2025-05-31
Duration (months): 32.0
Total project cost (EUR): 1999973.75
EU funding (EUR): 1999973.75
Participants: 10
Project status: CLOSED

BIOTRANSFORM provides European policymakers with an adequate assessment and policy development framework, knowledge base and expert support ecosystem to accelerate the transition from linear fossil-based systems to circular bio-based systems. It is therefore operating at the interface between the circular economy and the bioeconomy transitions. In this way, BIOTRANSFORM equips policymakers with the tools to set informed priorities that serve environmental, economic, and social goals, being actionable, future-proof, and align with supply-and-demand trends in related industries and value chains. BIOTRANSFORM’s “assessment package” will be tested by and provided for European policymakers, which will include 3 complementary tools: (i) resource flow analysis tool including circular innovations, (ii) a cutting-edge quick environmental, social and economic assessment tool, and (iii) a logistics management tool. To achieve this, BIOTRANSFORM develops and tests its framework to establish and roll out circular bio-based systems by applying a multi-actor approach around 6 regional cases: Andalusia (Spain), Northern Burgenland (Austria), Western Macedonia (Greece), Finland, Charles Spa Region (Czech Repulic) and North Rhine-Westphalia (Germany). These regional case studies represent several important industries and scenarios for Europe such as: forestry, agri-food, lake ecosystems, lignite and minerals, and chemicals. Action roadmaps will consider specific regional available resources and infrastructures, conversion pathways, logistics, current policies, strategies, and access to finance. In other words, BIOTRANSFORM builds on the concept of regenerative bioeconomy value cycles by tapping into what is there already and connecting the dots. In this concept, carbon is stored and nutrients are recovered. This concept shall be upscaled and replicated to many further European regions to achieve Europe's ambitious goals.

Keywords: circular bioeconomy,transition,policymakers,assessment tools,bioeconomy value cycles,bio cascading,connected biorefineries,green transition,digitalisation