Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Co-culture System with Microfluidics and Onboard Sensors for Breast Cancer study (CoSMOS-BC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

Breast cancer (BC) remains one of the leading causes of cancer-related deaths among women worldwide, with incidence rates rising and a significant economic burden. The disease is characterized by its dynamic and heterogeneous nature, involving complex molecular, genetic, and cellular changes. The tumor microenvironment (TME), particularly its inflammatory components such as cytokines, plays a crucial role in BC progression and treatment response. While targeted therapies have improved outcomes for some BC subtypes, significant challenges persist especially in treating triple-negative breast cancer (TNBC), which lacks specific molecular targets. The development of microfluidics devices that enable precise spatiotemporal control in cell culture offers new opportunities to simulate and study the TME more effectively than conventional methods. Such devices are crucial for modeling cancer progression and deepening our understanding of its biology. By mimicking human physiology, they provide a controlled platform for testing new therapies, reducing animal testing, and accelerating drug development. Additionally, they facilitate personalized medicine by recreating patient-specific tumor microenvironments and supporting tailored treatments. These advancements also bridge the gap between in vitro studies and clinical applications, driving oncology research forward and offering hope to millions of people. Aiming this, CoSMOS-BC proposes a microfluidic co-culture system with integrated sensors for real-time cytokine detection at the cellular level, designed to provide insights into intercellular communication and understand cellular dynamics within the TME. CoSMOS-BC has the potential to make significant strides in both the diagnosis and personalized treatment of breast cancer, paving the way for more effective and targeted therapeutic strategies.

Keywords: breast cancer,microfluidics,sensors,lab on chip devices,cytokines,conductive polymers
Sustainable, High-throughput, Industry-ready, Next-generation technology for European manufacturing leadership in PV (SHINE PV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Belgium,France,Austria,Estonia,Slovenia,Italy,Germany,Netherlands,Czechia,Switzerland,Ireland
Call: Alternative equipment and processes for advanced manufacturing of PV technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 14444024.78
EU funding (EUR): 12052018.1
Participants: 23
Project status: SIGNED

SHINE PV will develop alternative technological routes to PV production for Silicon Heterojunction and TOPCon solar cells, covering the three key steps in the back-end manufacturing: metallization, post-processing and interconnection. SHINE PV will demonstrate different flows and down-select the most promising ones in terms of cost of ownership and high volume manufacturing readiness. Advanced equipment at TRL7 with Industry 4.0 dedicated features, innovative materials and solutions will be developed. For the metallization, SHINE PV will introduce parallel dispensing and plating as High Volume Manufacturing (HVM) alternative processes to incumbent screen printing, with the objective of demonstrating the complete or partial replacement of Ag with Cu, a fundamental step to enable Tera-Watt scale production levels. Moreover, SHINE PV will increase the efficiency through cell post-processing by applying Light Soaking process in HVM and recover the cutting-induced losses by Edge Re-Passivation. For the module making step, the innovations in interconnection proposed are Twill and Shingling processes and HVM equipment. Both will leverage on the optimization of the metallization and post-processing steps and will demonstrate their potential in terms of superior electrical properties, aesthetics, reliability, and compatibility with premium module designs. The expectation of the project is to enable an increase of solar cell (or module) efficiency of 0.5% absolute versus the reference process with a simultaneous CoO reduction of 20%, due to reduced material costs and increased equipment productivity. SHINE PV project will demonstrate the integrated innovative processes and novel equipment both virtually and within physical pilots at industrial partners at TRL7. To our knowledge for all these technologies no production equipment is available for HVM worldwide, and we envision a great potential for a PV supply chain revamping in EU.

Keywords: metallization,interconnection,manufacturing,automation
“Molecular dissection of cytotoxic lymphocyte exocytosis (CL_Exocytosis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

My PhD experience in the field of immunology focused on deciphering vesicular pathways underlying T cell activation profoundly motivated my move to Dr. Bryceson’s lab, which offers a unique opportunity to explore cytotoxic lymphocyte (CL) exocytosis in the context of human disease. Cytotoxic lymphocyte exocytosis is critical for life, with mutations in genes required for cytotoxicity causative of severe, early-onset hyperinflammatory syndromes. Genetic studies have identified several cytosolic proteins required for CL exocytosis. However, understanding of how these proteins cooperate for exocytosis, their interaction partners and how their activities are regulated is still limited. I propose strategies to gain insight to the molecular regulation of human CL exocytosis. First, prompted by genetic studies, I aim to study the contribution of two distinct Munc13-4 isoforms to lymphocyte cytotoxicity by dissecting their role in cytotoxic granule (CG) exocytosis using advanced live-cell imaging as well as identifying their interaction partners using quantitative mass spectrometry (MS). Second, recycling endosome (RE) have recently been implicated in CG exocytosis, delivering syntaxin-11, an effector molecule required for CG fusion, to the plasma membrane. I plan to use a high-throughput MS approach to identify RE constituents and cargo in order to define new components that may be critical for CG exocytosis. Results will provide novel mechanistic insights to CL exocytosis, which will also be relevant for other exocytic systems. Providing detailed molecular understanding of lymphocyte cytotoxicity in both healthy and pathological conditions, insights promise to guide improved diagnosis and therapy of immune disorders associated with defects in lymphocyte cytotoxicity. Yearning to build a successful academic career, the excellence of the host laboratory will allow me to successfully purse this project and expand technical expertise and my scientific horizon.

Keywords: lymphocyte cytotoxicity,vesicular traffic,cytotoxic immune synapse,primary immunodeficiency,mass spectrometry analysis,advanced live cell imaging
Development of SmarT Eco-friendly anticontamination technologies for LAminaR wings (STELLAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Belgium,Belgium,Belgium,Belgium,France,France
Call: Anticontamination Coatings and Cleaning Solutions for Laminar Wings (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2023-10-31
Duration (months): 49.0
Total project cost (EUR): 1999771.25
EU funding (EUR): 1999771.25
Participants: 9
Project status: SIGNED

The aircraft industry is facing issues with the increase of drag directly impacting the fuel consumption of the fleet. Achieving natural laminar flow requires high surface quality. Tiny air flow disturbances at the surface can indeed cause an early transition from laminar to turbulent flow. The accumulation of insect debris on the leading edge of laminar wings has been recognized as one of the most significant operational concerns associated with laminar flow. The main objective of STELLAR is to develop efficient and durable anticontamination coating and cleaning solutions designed following a deep understanding of the insect residues properties. Hence, STELLAR project seeks to gain insight on the understanding of the biochemical transformation of hemolymph during flight phases and the consequent physico-chemical modification and interaction with the aircraft surface. In order to meet these goals, the project consortium gathers cutting edge multidisciplinary knowledge and the needed facilities to provide a deep understanding of the insect contamination issues. STELLAR approach has the potential to significantly enhance the current understanding of the key issues and highlight which surface characteristics have the greatest influence on insect residue adhesion. From this approach, new coating and cleaning solutions will be developed. The knowledge acquired and the coating and cleaning solutions developed will be evaluated through large scale tests: 1) wind tunnel tests will allow the simulation of the extreme conditions occuring during flights and 2) real aircraft tests, including short flight tests (on test aircraft) and long flight tests (on commercial aircraft), operating at higher altitudes will allow a full validation of the new solutions developed by the STELLAR project.

Keywords: aircraft,laminar flow,turbulence,insect,anticontamination coatings,self healing,slippery,hemolymph,fuel consumption,ecodesign
Mathematical analysis of fluid flows: the challenge of randomness (FluFloRan)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The main goal of the present project is to make substantial contributions to the understanding of fundamental problems in the mathematical theory of fluid flows. This theory is formulated in terms of systems of nonlinear partial differential equations (PDEs). Major attention has been paid to the iconic example, the Navier-Stokes system for incompressible fluids, and the corresponding Millennium Problem. Despite joint efforts and a substantial progress for various models in fluid dynamics, fundamental questions concerning existence and uniqueness of solutions as well as long time behavior remain unsolved. This project is based on the conviction that a probabilistic description is indispensable in modeling of fluid flows to capture the chaotic behavior of deterministic systems after blow-up, and to describe model uncertainties due to high sensitivity to input data or parameter reduction. For a set of selected models, we investigate different aspects of the underlying deterministic and stochastic PDE dynamics. In particular, we are concerned with the question of solvability and well-posedness or alternatively ill-posedness. For some models including the incompressible stochastic Navier-Stokes system we investigate non-uniqueness in law. For the compressible counterpart we aim to prove existence of a unique ergodic invariant measure. The guiding theme of this research program is a core question in the field, namely, how to select physically relevant solutions to PDEs in fluid dynamics. The project lies at the challenging frontiers of PDE theory and probability theory and it will tackle several long standing open problems. The results will have an impact in the deterministic PDE theory, stochastic partial differential equations and from a wider perspective also in mathematical physics.

Keywords: fluid dynamics,stochastic partial differential equations,navier stokes system,solvability,non uniqueness in law,ergodicity
Adolescents’ education transitions: Multiple insights into the process dynamics of goal-construction and youth actions over time (TeenEduGoals)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

The literature recognizes (1) that to date little is known about how individuals change and where differences between them come from; (2) the need to deepen our understanding and ability to intervene in the manifest, social and subjective processes occurring during adolescence. This requires the adoption of more radical approaches to the study of development allowing the field to move beyond its current emphasis on individual processes and ease in the adoption of a more holistic, dynamic understanding of how young people build meaning across time and in certain contexts. It is the aim of our research to bring together 3 perspectives (developmental life span psychology, dynamic systems approach, contextual action theory) allowing complementary insights into the process dynamics of goal-construction and youth actions over time during adolescence. The specific domains of observation will be peer relationships and youth education transitions from early to late adolescence and young adulthood in Finland. The achievement of the work package objectives will entail (1) learning by research and hands-on training activities, (2) involvement with the research and financial planning of the study, (3) me expanding my network of collaborations. The project will help me improve my career prospects and employability, thus to progress from the early career stage to a consolidated position in a competitive academic institution. It will also help me assert myself as an expert (1) on the theoretical and methodological approaches informing the research project, (2) on adolescents’ education transitions and related interventions. We will (1) derive implications for future research, intervention and policy, (2) disseminate and communicate our findings as widely as possible to effectively transfer the knowledge acquired with the project to other researchers, sectors and disciplines (e.g., through scholarly publications, media briefs, workshops, seminars/meetings with community members).

Keywords: adolescents,education pathways and transitions,goal construction,change patterns,individual change process,joint actions and projects,peers,integrative framework
Past, Present, and Future Lives of Soviet Housing Estates in the Baltic States (Baltic Mikrorayon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Estonia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 148582.8
EU funding (EUR): 148582.8
Participants: 1
Project status: CLOSED

In Central and Eastern Europe (CEE), modernist housing estates, built between the 1950s and 1990s to meet housing demand and rebuild cities after World War II, introduced revolutionary changes in urbanization. Today, overcoming the challenges posed by vast housing estates presents one of the greatest challenges faced in post-Socialist cities. To address a gap in knowledge about socialist urban planning implementation (especially the construction of mikrorayon) in the Baltic States, I propose to interview planners and architects who were active practitioners during the Soviet era (as well as those practicing more recently) to analyse past, present, and future lives of housing estates in Estonia, Latvia and Lithuania. The project proposed for this IF is not only a natural progression of my research trajectory, it is also transformative because it applies my expertise to multi-disciplinary research that covers a range of research questions and avenues of inquiry. The project will produce broad impacts on research methods (interviews of original “actors” in residential settlements), new knowledge on the history of urbanization, and recommendations for present-day urban planning in cities in CEE. This Individual Fellowship requires a 24-month academic stay at the University of Tartu (UT), Estonia where I will engage in training-through-research supervised by Prof. Tiit Tammaru, Professor and Senior Research Fellow in the Institute of Human Geography at UT. The project will give me new hands-on experience in interviewing and archival research and I will produce important publications that will (1) help me establish myself as the pre-eminent North American scholar on architecture, town planning, and urban geography in the Baltic States, and (2) assist my career advancement (from Associate Professor to Professor) at my home institution, the University at Buffalo.

Keywords: architecture,town planning,urban history,urban planning,urbanization
At the crossroad of molecular physics, quantum optics and spectroscopy: ultra-high-precision molecular spectroscopy for fundamental physics (PREMOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2025-08-31
Duration (months): 84.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Molecules have an enormous potential in the field of frequency metrology-based fundamental physics, yet have so far not played an important role, due to difficult experimental challenges. The goal of this project is to overcome these difficulties by developing new techniques, thus opening a new chapter in precision molecular spectroscopy. Furthermore, it will have far-reaching impact in fundamental physics: (1) A 500-fold improved limit to the existence of a “fifth force” with range on the 0.1 nm scale. (2) An independently determined set of the fundamental constants me/mp, me/md, and the Rydberg constant R∞. Their uncertainties will be reduced compared to CODATA2014 by up to a factor of 23 for me/mp, 4 for me/md, and 2 for R∞; (3) A test of the current muonic atom discrepancies of proton and deuteron charge radii rp and rd at the 30% and 50% level, respectively; (4) Achieve a precision 1×10-16 in molecular ion spectroscopy, thus exploring the feasibility of using, in the future, molecular ions for testing the time-dependence of me/mp and mp/md. Molecular hydrogen ions (MHIs) are the systems in principle suitable for providing these results: indeed, the required ab initio theory has made outstanding advances, reaching the 8×10-12 inaccuracy level. To date, experimental results are orders of magnitude less precise. In order to achieve an accuracy surpassing the theoretical one, this project shall develop new quantum optical techniques, including: - Doppler-free spectroscopy, rotational and ro-vibrational; - preparation of a single molecular ion in a single internal quantum state; - resolution and control of systematic shifts at levels from 1×10-12 to 1×10-16; - novel spectroscopy laser systems. These techniques will be of general applicability in the field of molecular ion spectroscopy. The proposed work is based on the wide experience of the PI in precision measurements and will make a strong and overdue contribution to spectroscopy and fundamental physics.

Keywords: ion trap,laser cooling,sympathetic cooling,quantum three body problem,molecular hydrogen ion,fundamental constants,rydberg constant,electron mass,deuteron mass,proton mass
PROPOSAL FOR FUNDING RESEARCH DEVELOPMENT AND MANUFACTURING OF VACCINE AGAINST COVID-19 (COVID-19 VACCINES)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Specific Grant agreement
Countries involved: Norway
Call: Grant to the Coalition for Epidemic Preparedness Innovations (CEPI) (H2020-SGA-SC1-CEPI-2020, 2020)
Start date: 2020-07-24
End date: 2026-01-23
Duration (months): 66.0
Total project cost (EUR): 150000000.0
EU funding (EUR): 100000000.0
Participants: 1
Project status: SIGNED

Funding of research and innovation programmes for the development of novel SARS-CoV-2 vaccine against COVID-19 disease The overall objective is to leverage co-funding from the European Commission to support CEPI’s COVID-19 vaccine programme development efforts. The COVID-19 outbreak has in a short timeframe grown to a global pandemic of historic proportions, with detrimental humanitarian and economic consequences. All evidence now suggests that eradication of COVID-19 is not feasible and that we face a global public health crisis which is unprecedented in modern times. Investing in vaccine development now is an investment in the future health for all in our societies and a return to social and economic development – both in Europe and in the rest of the globe. CEPI is seeking to support scientifically excellent research and development vaccine development programmes of a nature that will allow the broadest global access of the vaccines that are ultimately developed both within the current pandemic crisis and beyond. This will help curb the current ongoing outbreak, that is resulting in human suffering and a grave global economic crisis. CEPI was set up to respond to the crisis, where our vision is a world in which epidemics are no longer a threat to humanity. Our strategic objectives are further aligned with the sustainable development goals 3, 8 and 17. Of particular importance to CEPI’s work is to try and ensure that low- and low-middle income countries (LICs and LMICs, respectively) will have access to the vaccines to protect their most vulnerable population, as soon as a vaccine is made available and irrespective of their ability to pay. As the current pandemic has shown, viruses respect no borders. To successfully curb the COVID-19 pandemic and beyond, we must ensure that all countries have the necessary tools to control the outbreak domestically. No-one is safe until everyone is safe.

Keywords: covid 19,vaccine development,clinical trials,randd,epidemiology,sars cov 2