Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Laser Nanoscale Manufacturing (LASERNAMI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland,United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 347400.0
EU funding (EUR): 347400.0
Participants: 3
Project status: CLOSED

The project “Laser Nanoscale Manufacturing (LaserNaMi)” focuses on staff exchanging between the partners, especially between the partners of EU and China, on researching and developing new maskless laser nanoscale manufacturing technologies for low cost, simple and high speed manufacturing of nano structured surfaces and components including periodic structures (nano gratings, anti-counterfeiting security markers, nanoimprint templates, self-cleaning and antireflection surface nano-structures) and other arbitrary features. LaserNaMi has the following objectives : (1) To exchange ideas and technology concepts to further development on the new maskless laser nanoscale manufacturing technologies. (2) To complement fabrication and characterization technologies with other technologies of partners in the LaserNaMi consortium to produce nanostructures in thin-films. (3) To explore novel applications for the laser nanoscale manufacturing from the combination of the different backgrounds and disciplines of the partners of LaserNaMi. (4) To strengthen research partnerships through staff exchanges and networking activities between European research organisations and organisations from China. (5) To establish long-term research cooperation through the proposed coordinated joint programme of exchange of researchers for short periods during the project. LaserNaMi meets the objectives and requirements of the Marie Curie Action: International Research Staff Exchange Scheme (IRSES), and it will provide support to the consortium members to establish and reinforce long-term research cooperation in laser nanoscale manufacturing through a coordinated joint programme of exchange of researchers.

Keywords: nanotechnology,nanodevices,nanosystems
Support to policy dialogues and strengthening of cooperation with Southeast Asia (SEALING)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Horizontal support actions
Action type: Coordination and support actions
Countries involved: France,Philippines,Indonesia,Singapore,Thailand,Brunei Darussalam,Myanmar,Malaysia,Lao People's Democratic Republic,Viet Nam,Cambodia
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 954500.0
EU funding (EUR): 643000.0
Participants: 11
Project status: CLOSED

The SEALING project, targeting the objective 9.1a of the FP7 ICT work programme, aims at supporting the development of Information Society policy dialogues and the strengthening of cooperation on ICT research with the ASEAN region in general (a region of strategic importance for the EU), and with Singapore in particular (a country with which a MoU on ICT has been signed). It builds on the results achieved and the experience gained through the FP7 SEACOOP project, which has already supported, over the period 2007-2009, the development of S&T cooperation in ICT between the two regions. On the Southeast Asian side, the SEALING partnership includes the organisation managing ICT research in each of the ten ASEAN countries and is formally supported by the ASEAN Secretariat. On the European side, the project involves, through a Project Advisory Committee, over 20 leading companies, research institutes and academia. The project is also supported by the main European Technology Platforms and Joint Technology Initiatives in the ICT area, and by key European initiatives in Southeast Asia, namely the EU-SEA-NET INCO-Net project and the TEIN3 initiative. The SEALING project will develop its activities over a 2-year period: • Organization of at least 6 cooperation events in Europe and in Southeast Asia to be synchronised with policy dialogue meetings, • Identification and analysis of ICT policy and research priorities, at bilateral and regional levels, and provision of recommendations for future cooperation initiatives, • Development of synergies with dialogues and activities launched under EU-funded programmes (EU-SEA-NET, TEIN3, Marie Curie, etc.), at the initiative of EU Member States and Associated States, and at the ASEAN level (SCMIT), • Development of promotion, dissemination and awareness-raising activities.

Keywords: international cooperation - southeast asia - asean - ict research
Transport studies on polymer based nanodevices and assemblies for delivery and sensing (TRASNADE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Germany
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-12-01
End date: 2014-05-31
Duration (months): 42.0
Total project cost (EUR): 306000.0
EU funding (EUR): 306000.0
Participants: 2
Project status: CLOSED

TRANSNADE is designated for the study of the transport properties of nanoscale assemblies and devices fabricated from polymers and polyelectrolytes, such as polyelectrolyte multilayers, polyelectrolyte brushes, polymer micelles, and polymersomes. Transport properties are fundamental for the rational design of delivery devices since the mechanism of transport will finally define release properties. For most of the mentioned nanodevices, transport properties are adjusted in an empirical way. A deeper understanding of the underlying principles and mechanisms of transport of matter is highly desirable. Polymer nanoassemblies in aqueous environments are heterogeneous and at least partly random systems. A complex scenario of interactions for the diffusing species with the nanomaterial can be expected resulting in unusual transport properties. Measuring transport properties at the nanoscale requires novel experimental and theoretical approaches. A multidisciplinary approach is needed, ranging from synthesis, self assembly, to physical chemistry and theoretical physics. TRANSNADE is formed by an international team with the required and complementary expertise. The expertise of Prof. Gao, from Zhejian University , in synthetic chemistry and self assembly together with the expertise of Dr. Moya, from CIC biomaGUNE, in materials science will be paramount for the creation of polymer with specific functions to be integrated on devices and assemblies. Prof. Donath from the University of Leipzig will develop a novel reaction-diffusion approach for diffusion measurements in nanoassemblies. Electrochemical measurements of transport will be performed by Dr.O.Azzaroni, from INIFTA and Dr.Moya will focus on solvent transport by designing an optical setup combined with QCM. Prof.V.Arakelyan from the Yerevan State University and Prof. Donath will join together their expertise in theoretical and soft matter physics to model experimental data and establish a mechanism for transport.

Keywords: transport,nanodevices,drug delivery,soft matter physics,polymer chemestry,self assemblies,electro chemestry,fluorescense techniques
Petahertz Quantum Optoelectronic Communication (PETACom)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Hungary,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 3922730.75
EU funding (EUR): 3922730.0
Participants: 9
Project status: SIGNED

Today, switching speeds in the multi gigahertz range are technologically mastered and terahertz electronics is at its birth. Soon electronic components will push forward towards the petahertz range. It is however unknown how the movement of electrons can be controlled at such frequencies. 2D and 3D semiconductors exhibit properties of high electron mobility that allows to drive intense electron currents coherently in the conduction band when submitted to terawatt laser fields. A strong electron current oscillates at petahertz frequencies in the conduction band with a momentum that depends on the laser field frequency, intensity, polarization and career envelope phase. In addition, high order harmonic radiation is emitted when those electrons recombine to the valence band. The strong electron current from which HHG originate can be manipulated in space and time and be the very first elementary blocks of novel petahertz frequency electronic devices, thus operating orders of magnitude faster than the state-of-the-art terahertz devices. The PETACom project proposes to create future optoelectronic device commutating at petahertz frequencies, bridging the gap between electronics and photonics. We will establish: 1) Petahertz electron switching in 2D and 3D systems using intense femtosecond IR to mid-IR laser excitation. 2) Optoelectronic devices from laser induced petahertz electron oscillation. 3) A new paradigm for future electronics and ultrahigh speed communication and computation.

Keywords: ultrafast electronics attosecond laser petahertz terahertz
Netherlandish Paintings in Ledreborg Palace: A Multi-Disciplinary Research of circa 600 Paintings (NePLeP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-25
End date: 2019-04-24
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

More than 600 Netherlandish seventeenth century paintings decorate the walls of Ledreborg Palace (Lejre, Denmark). The painting collection, of which a large share presumably was brought together in the first half of the eighteenth-century, consists mostly of mass-produced paintings, a novel commodity of the seventeenth century. Fascinatingly, Ledreborg Palace is not the only collection in Denmark which displays a strong emphasis on Netherlandish paintings: at least 2 other (also not disclosed) collections are known. However, the question why the Danish seem to have had a strong interest in Netherlandish paintings remains unanswered. This research will contribute to understanding the strong interest in Netherlandish paintings in Denmark during the seventeenth through eighteenth centuries by focusing on the collection of Ledreborg Palace. All the paintings will be thoroughly examined from an art historical viewpoint, however, also technical studies such as infrared and X-ray images will be carried out in order to understand also the artists working methods in their mass-production endavours to supply the entire European continent with affordable paintings. The overall result will be an improved understanding of the spread of Netherlandish art and the means by which this could be done. All the achieved data will be accessible for researchers and the public through an open-access database with 600 annotated paintings including an art historical and technical study of a carefully selected part of these hitherto undocumented and unstudied paintings. Simultaneously the latest expertise in socio economic art history will be employed to situate the paintings in a European framework of the seventeenth century and their importance to the society of today. The project will provide the young professional researcher with new and essential training to become an expert in the application both technical instruments and socio-economical study of Netherlandish paintings.

Keywords: netherlandish art,denmark,examination of paintings,multidisciplinary research
Higher Order Polar calculus and Euclidean distance degree (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Polar varieties are central objects in algebraic geometry. Every subvariety in a projective space has an associated list of polar varieties, encoding its tangential properties. Their degrees determine codimension and degree of the dual variety. Moreover, under mild generality assumptions, the polar degrees sum up to the Euclidean distance degree. This quantity is the algebraic degree of the distance of the given variety to a generic point in projective space. It plays an important role in the context of variety learning and algebraic sampling. Recently it has been shown that the polar degrees of a projective variety coincide with the degrees of its coisotropic hypersurfaces. These hypersurfaces live inside Grassmannians and appear naturally in computer vision. Many of the above objects have been generalized to higher order analogues. Our goal is to extend this generalization to polar geometry to capture higher tangency properties of projective varieties. Projective duality has been expanded to higher order duality by allowing higher order contact, called osculation. Coisotropic hypersurfaces have been generalized to coisotropic varieties, which have arbitrary codimension in their ambient Grassmannian. We will introduce a new notion of higher order polar varieties to create the missing link between higher order duality and coisotropic varieties. We will also study higher order Euclidean distance degrees, describe our new concepts especially for toric varieties, and analyze their tropicalizations. This project is foundational research within algebraic geometry with a view towards computations and applications in computer vision and algebraic sampling. In addition to algebro-geometric methods (such as intersection theory or the study of resultants and discriminants) it requires techniques from a variety of other disciplines, such as combinatorics, convex geometry, statistics, computer vision, tropical geometry, and both symbolic and numerical computations.

Keywords: polar variety,projective duality,osculating space,chern class,euclidean distance degree,coisotropic variety,grassmannian,toric embedding,tropicalization,computer vision,algebraic sampling
Exploring the market potential of photoporation as the next generation of intracellular delivery technology for the R&D and cell therapy markets (INTRACYTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-02-01
End date: 2022-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Delivering macromolecular compounds into living cells in vitro or ex vivo is a common requirement for both fundamental biological research as well as biomedical applications. Examples include the intracellular delivery of gene editing molecules to unravel molecular pathways or to create engineered therapeutic cells. Irrespective of the application, the common challenge is to combine efficient intracellular delivery with flexibility, high throughput and low cytotoxicity. Photoporation, which combines laser irradiation with light-sensitive nanomaterials, is an upcoming physical intracellular delivery technology that offers these benefits. Over several years of research in the principal investigator’s group, photoporation has proven its worth to deliver a variety of molecules into a broad range of cell types, including primary hard-to-transfect cells. Offering high delivery efficiency, low cytotoxicity, single cell precision and minimal hands-on time, it holds great promise to become the next generation of intracellular delivery technologies. Having developed prototype devices which already have been validated by several independent partners, the time has come to fully explore the technology's market potential. The first aim of the INTRACYTE project is to further confirm interest from the academic and industrial R&D market by installing the technology at selected international Key Opinion Leaders (KOLs) for an extensive validation in variety of topics. The second aim is to explore the cell therapy market by initiating discussions with interested companies in order to fine-tune the technology’s value proposition and to define technical requirements for use in a cell production facility. Thirdly, upscaling of nanomaterial production will be investigated, apart from the design of a low-cost bench-top photoporation instrument. Together this should lay the foundation bring this exciting new technology to the market within the next 12 months.

Keywords: drug delivery,cell therapy,transfection,intracellular delivery,biophotonics,valorization,spin off
Universal regulatory library for any cell type (UNILIB)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Israel
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-07-01
End date: 2020-12-31
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project. As part of the results of MRG-Grammar, we have developed a universal regulatory library that is made of binding sites motifs that have been shown to be highly active in every cell type that we have tested from yeast to mammalians. The library is synthesized with a new composite-base technology that was also developed in MRG-Grammar. In this study, we propose to explore the application space for the universal library and resultant market potential. Requested funding will be used to complete the universal library proto-type and to demonstrate that expression of a biologic can be optimized with this tool. In addition, we will explore a potential service model, business model, and a licensing mechanism for the dissemination of the universal library for various stake-holders in the academia and private sectors.

Keywords: synthetic enhancers,cis regulatory modules,regulatory grammar,transcription factor binding sites
Regulation of antibody responses by B cell mechanical activity (BCELLMECHANICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-05-31
Duration (months): 81.0
Total project cost (EUR): 1999386.0
EU funding (EUR): 703510.36
Participants: 2
Project status: CLOSED

The production of antibodies against pathogens is an effective mechanism of protection against a wide range of infections. However, some pathogens evade antibody responses by rapidly changing their composition. Designing vaccines that elicit antibody responses against invariant parts of the pathogen is a rational strategy to combat existing and emerging pathogens. Production of antibodies is initiated by binding of B cell receptors (BCRs) to foreign antigens presented on the surfaces of antigen presenting cells. This binding induces B cell signalling and internalisation of the antigens for presentation to helper T cells. Although it is known that T cell help controls B cell expansion and differentiation into antibody-secreting and memory B cells, how the strength of antigen binding to the BCR regulates antigen internalisation remains poorly understood. As a result, the response and the affinity maturation of individual B cell clones are difficult to predict, posing a problem for the design of next-generation vaccines. My aim is to develop an understanding of the cellular mechanisms that underlie critical B cell activation steps. My laboratory has recently described that B cells use mechanical forces to extract antigens from antigen presenting cells. We hypothesise that application of mechanical forces tests BCR binding strength and thereby regulates B cell clonal selection during antibody affinity maturation and responses to pathogen evasion. We propose to test this hypothesis by (1) determining the magnitude and timing of the forces generated by B cells, and (2) determining the role of the mechanical properties of BCR-antigen bonds in affinity maturation and (3) in the development of broadly neutralising antibodies. We expect that the results of these studies will contribute to our understanding of the mechanisms that regulate the antibody repertoire in response to infections and have practical implications for the development of vaccines.

Keywords: b cell,antibody,immune synapse,antigen,endocytosis,signalling,single molecule,force,affinity maturation