Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coordinated Development of Inhibitors and Biomarkers for Resistance to Antiangiogenics in Cancer - AngioResist (AngioResist)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 149931.68
EU funding (EUR): 149931.68
Participants: 1
Project status: CLOSED

Many anti-angiogenic drugs are clinically used in several types of cancer to block angiogenesis, impair tumor growth, progression and dissemination. Nevertheless, clinical trials report emergence of resistance to treatment and a failure in long-lasting effects of these therapies. To date, resistant patients do not currently have any established, proven alternative therapeutic possibility and the medical field is moving towards a careful selection of subgroups or subtypes of patients that have to be treated with each one of the available second-line targeted drugs. For this relevant unmet medical need, many laboratories and pharmaceutical companies have focused on developing new biomarkers and new drugs to fight anti-angiogenic resistance, but up to date, there is no proven established biomarker or method to predict which patient’s tumor is resistant to antiangiogenic therapies and which drug is capable of blocking this resistance to therapy. AngioResist PoC aims at solving the existing patient selection gap in the treatment of cancer that is therapeutically resistant to antiangiogenic drugs. Based on data generated from our ERC project and two filed European Patent applications, AngioResist PoC will transform the acquired basic knowledge into an Innovation project, to validate a novel biomarker of response/resistance to antiangiogenics together with a new inhibitor for the treatment of these selected patients. The project will coordinately perform the preclinical phases of development of the drug compound and the biomarker, with the final aim of licensing them both to a selected partner during the clinical phases. Together with our licensee, we aim at the final distribution of a therapeutic drug that will be delivered with a biomarker kit for the selection and treatment of cancer patients resistant to antiangiogenic drugs.

Keywords: cancer,targeted therapies,anti angiogenic therapies,therapeutic resistance,biomarkers,predictive factors of response,patient selection for treatment
European Research and Innovation Centre of Excellence in ChiNA (ERICENA)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,China,Norway,Greece,Belgium,Switzerland,Portugal
Call: Centres/Networks of European research and innovation (H2020-SC6-ENG-GLOBALLY-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 3589000.0
EU funding (EUR): 2997600.0
Participants: 14
Project status: CLOSED

Europe actively engages internationally to strengthen its leadership in the field of Science, Technology and Innovation (STI) in the global scene and improve synergies between Member States. Europe aims to foster international cooperation and strengthen its STI presence in China due to its growing importance and STI opportunities for European actors. ERICENA (European Research Innovation Centre of Excellence in China), a 48 month initiative implemented by 8 European and 5 Chinese partners, proposes to set up a Centre and its networks in China to promote European STI interests in China, creating synergies with existing STI structures. ERICENA will connect and support European researchers, entrepreneurs and other STI stakeholders, while providing and facilitating provision of STI services (e.g. networking, advice and support, training, among others) to private and public clients. The Centre will be implemented along 4 stages (initial set-up, pilot, full operational and self-sustainable stages), in which all mechanisms will be structured and established to ensure the Centre’s long-term sustainable operation in China. The Centre will be established through the implementation of 6 strategic WPs, which are structured along 4 key pillars – strategy, operational, financial and implementation – as well as two cross-cutting supporting WPs. ERICENA will effectively contribute to improve cooperation between European STI organisations and researchers and their Chinese counterparts, strengthen the presence of European STI excellence in the Chinese market, maximize the impact of European STI actors in China, improve the framework conditions for EU-China cooperation, and expand the impact of results from existing European STI projects and initiatives in China. This vision will be closely supported and empowered through the wide involvement of stakeholders, including the consortium and more than 100 STI stakeholders in the EU and China involved as Associated Partners.

Keywords: science,technology and innovation sti,entrepreneurship,startup,business plan,sustainability,eu china cooperation,centre,services,technology transfer,research and innovation,stakeholders
Structural studies of Na,K-ATPase isoforms and mutants (NaKStruc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Isoform complexes of Na,K-ATPase , an αβ-heterooligomer, have recently been identified as crucial regulators of muscle and neural physiology and were furthermore identified as the primary cause of neurological diseases. Of particular interest are α2β2 & α2β3, which are expressed in muscle and astrocytes (α2β2) and the ciliary body (α2β3). Both exhibit a significantly lower affinity for K-ions and a steeper voltage dependence than the housekeeping α1β1 complex. These features keep α2-isoforms inactive at resting conditions but allow to respond to transient elevations of extracellular K after muscle and neuronal activity. Moreover, both complexes can be selectively inhibited by cardiac steroids, making them promising drug targets for the treatment of heart failure (α2β2) and glaucoma (α2β3). Differences in affinity for K and cardiac steroids were attributed to the β-subunit recently, yet the root cause and molecular details remained elusive. Hence, I propose to investigate the structure of α2-isoforms purified from the yeast Pichia pastoris by x-ray crystallography and cryo electron microscopy. In addition to its physiological and pharmacological role mutations of Na,K-ATPase cause severe neurological diseases, e.g. Alternating Hemiplegia of Childhhod. Disease mutations typically inactivate the Na-pump causing severe motor and cognitive disorder. However, the effects of mutations on the ATPase’s reaction cycle have not been investigated in detail, leaving the cause of inactivation in the dark. Part two of the proposal addresses this gap of knowledge. The two most common mutations E815K and D801N will be expressed in P. pastoris and the effect of mutations on partial reactions of the Na,K-ATPase’s reaction cycle will be investigated and subsequently, structural studies will be carried out. This work will promote our understanding of Na,K-ATPase in health and disease and lay the foundation for the development of new drugs.

Keywords: k atpase,2 isoforms,atp1a3,alternating hemiplegia of childhood,cradiotonic steroids,cryo em,x ray crystallography,pichia pastoris
Antidepressant discontinuation during pregnancy and relapse risk in the perinatal period (PregnancyAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 201392.64
EU funding (EUR): 201392.64
Participants: 2
Project status: CLOSED

Antidepressants are the mainstay of pharmacological treatment for depressive and anxiety disorders in the perinatal period, and up to one in ten pregnant women take them. Among these women, over 50% discontinue antidepressants during pregnancy due to fear of possible adverse fetal effects. However, discontinuation may increase the risk of relapse, which can also have profound negative impacts. Evidence on perinatal relapse risk following antidepressant discontinuation during pregnancy is sparse and limited to highly selected populations. Moreover, the only factors considered in studies so far have been simple demographics and clinical features, while genetic profiling is conspicuously absent. The project aims to address knowledge gaps which urgently need to be understood in order for clinical care to provide personalized antidepressant treatment recommendations around pregnancy. This overarching objective will identify women at low or high relapse risk after discontinuing antidepressants during pregnancy and determine risk factors of relapse to enable personal risk estimates for the first time, in a large representative population, combining demographics, clinical features and genetic data retrieved from Danish national registers and the Integrative Psychiatric Research (iPSYCH) cohort. The project will provide a unique opportunity due to its multidisciplinary nature and innovative combinations of genetics and epidemiology. The proposed research will benefit from the expertise in genetics, genomics, and psychiatric epidemiology of the supervisors, and the fellow’s multidisciplinary skills in epidemiology and biostatistics applied on large, highly complicated datasets. The fellow will acquire state-of-the-art skills in the analysis of genetic data, planning, and management by training-through-research along with coursework. This project will form a fundamental leap towards her future independent career as a leading and international recognized epidemiologist.

Keywords: antidepressant treatment,polygenic,genetic risk score,relapse,reproductive epidemiology,pharmacoepidemiology,psychiatric epidemiology,pregnancy,perinatal,population based study,cohort study
A Molecular Framework for Plant Cell Totipotency (POTENTIATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

This proposal aims to unravel to signalling pathways that underlie induced plant cell totipotency, by combining cell and molecular techniques to chart the changes that take place as differentiated pollen cells are induced to switch developmental pathways and form embryos in culture. Immature male gametophytes can be induced to change their developmental fate from pollen to haploid embryo development when exposed to stress treatments in vitro. This process (microspore embryogenesis) is widely exploited in plant breeding to generate homozygous (doubled-haploid) lines in a single generation, and also provides a unique system to understand plant totipotency and early cell fate decisions. In this proposal, I aim to understand the molecular basis for this switch in developmental pathways in Brassica napus. I will combine cell tracking, cell sorting of fluorescently tagged cells and high-throughput transcriptome sequencing to chart the changes that take place as immature pollen are converted into haploid embryos, and will also determine the function of a selection of genes in the model plant, arabidopsis. The project will advance my career by broadening my existing cell biology expertise, by providing training in a new field, molecular biology, and by allowing me to work with the plant model, arabidopsis. In addition, my network will be expanded to include a large group of internationally active scientists and seed companies. This novel combination of classical and state-of the-art skills, combined with the experience of working with top international groups and a plant breeding company, will place me in a solid position for a career in academia or industry.

Keywords: totipotency
Advanced Braking Module with Cyclic Energy Recovery System (CERS) for enhanced reliability and performance of Wave Energy Converters (WaveBoost)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Sweden,Sweden,Sweden,Sweden,United Kingdom,Portugal,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 3988744.0
EU funding (EUR): 3988744.0
Participants: 9
Project status: CLOSED

WaveBoost aims at providing a step-change improvement to the reliability and performance of PTOs (Power-Take-Offs), by developing and validating an innovative braking module with a Cyclic Energy Recovery System (CERS). While built and tested on the platform of the existing CorPower technology, the CERS braking module can be integrated in many types of Wave Energy Converters (WECs). Especially for point absorbers - undisputedly the WEC type with best prospects for large-scale development - WaveBoost will solve a central reliability challenge, the so-called 'end-stop' problem (excessive, uncontrolled forces when linear movement reaches end of stroke). Further, dedicated reliability assessment methods will be developed and applied. CERS is an energy redistribution system that will allow WECs to absorb more energy from high energy wave cycles, temporarily storing excessive energy in the first step of the PTO chain, then releasing it for conversion through the remaining steps of the PTO in low energy wave cycles. Similar systems are being used in other sectors (e.g. automotive) but have not been applied to ocean energy. The additional damping force required to safely stop the motion of WECs in storm waves may be several times larger than the PTO force used to convert wave motion into electricity. By providing the extra damping needed from the CERS module, system survivability and reliability of critical components are significantly improved. Another consequence is a size reduction of the PTO for the same power rating, and an increase of the Annual Electricity Production (AEP). The technology allows WECS to operate at higher average loading, increasing average conversion efficiency. Further, the grid compliance of electricity produced is significantly improved through this new energy storage concept. The improvements described above are expected to significantly reduce shock loads on WECs, increase in AEP of 25% and reduce LCOE more than 30% compared to the state of art.

Keywords: wave energy,reliability,end stop,performance improvement,pto improvement,ocean energy,grid integration,grid compliance
Passive seismic scanning of the preparation phase of damaging earthquakes (FaultScan)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,United States
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-05-31
Duration (months): 72.0
Total project cost (EUR): 2524630.0
EU funding (EUR): 1974630.0
Participants: 3
Project status: SIGNED

The recent September 2017, magnitude 7.1, central Mexico earthquake that caused 370 casualties reminds us that earthquakes are among the most dramatic natural disasters worldwide. Causal physical processes are not instantaneous and laboratory and numerical experiments predict that earthquakes should be preceded by a detectable slow preparation phase. Despite considerable efforts, however, robust geophysical precursors have not yet been observed before damaging earthquakes. My FaultScan project will revolutionize our ability to directly observe transient deformation within the core of active faults and provide unprecedented accuracy in the detection of earthquake precursors. My ambition is to develop a new, noise-based, high resolution, seismic monitoring approach. I intend to grasp the opportunity of a recent step change in seismic instrumentation and data processing capabilities to achieve a dream for seismologists: reproduce repeatable, daily, virtual seismic sources that can probe the core of active faults at seismogenic depths using only passive seismic records. I plan to target the San Jacinto Fault (a branch of the San Andreas Fault system) that is currently believed to pose one of the largest seismic risks in California. It is an ideal fault for this project because it is very active, already extensively studied and easily accessible for the pilot field data acquisition work. This project is in collaboration with the Univ. of South. California, the Univ. of Cal. San Diego and specialists in earthquake mechanics and will include earthquake preparation processes and seismic modeling that will guide us for our long-term (3 years), breakthrough, passive seismic experiment and further data analysis and interpretation. I strongly believe that this project has a very high potential for providing fundamental results on the physics of earthquakes and faults and that it will have a major impact on earthquake prediction worldwide in the near future.

Keywords: noise based seismology,earthquake monitoring and prediction
Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration (Disc4All)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Switzerland,Belgium,Finland,Greece,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 3996776.52
EU funding (EUR): 3996776.52
Participants: 11
Project status: SIGNED

The European community requires early stage researchers (ESRs) who can work across the boundaries of traditional disciplines, integrating experimental and in silico approaches to understand and manage complex multifactorial disorders. This training network utilises intervertebral disc degeneration (LDD) leading to low back pain (LBP) as a relevant application for data integration and computational simulations in translational medicine. LBP is the largest cause of morbidity worldwide, yet there remains controversy as to the specific cause leading to poor treatment options and prognosis. LDD is reported to account for 50% of LBP in young adults, but the interplay of factors from genetics, environmental, cellular responses and social and psychological factors is poorly understood. Unfortunately, the integration of such data into a holistic and rational map of degenerative processes and risk factors has not been achieved, requiring creation of professional crosscompetencies, which current training programmes fail to address. Disc4All aims to tackle this issue through collaborative expertise of clinicians; computational physicists and biologists; geneticists; computer scientists; cell and molecular biologists; microbiologists; bioinformaticians; and industrial partners. It provides interdisciplinary training in data curation and integration; experimental and theoretical/computational modelling; computer algorithm development; tool generation; and model and simulation platforms to transparently integrate primary data for enhanced clinical interpretations through models and simulations. Complementary training is offered in dissemination; project management; research integrity; ethics; regulation; policy; business strategy; and public and patient engagement. The Disc4All ESRs will provide a new generation of internationally mobile professionals with unique skill sets for the development of thriving careers in translational research applied to multifactorial disorders.

Keywords: multiscale modelling,bioinformatics,intervertebral disc,translational research,mechanobiology