Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
6G eXperimental Research infrastructure to enable next-generation XR services (6G-XR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Finland,Spain,Slovakia,Germany,Belgium,Portugal,Switzerland,United Kingdom
Call: SNS experimental Infrastructure (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 9421131.75
EU funding (EUR): 9024623.0
Participants: 18
Project status: SIGNED

6G eXperimental research infRastructure to enable next-generation XR services (6G-XR) will develop an evolvable experimental infrastructure for the duration of the SNS programme that covers demonstrating the performance of key B5G/6G candidate technologies, components, and architectures to keep the infrastuctures valid now, in mid-term and in long-term. It will demonstrate technological feasibility of “better than 5G” KPIs, innovative radio spectrum technologies and the use and sharing applicable to beyond 5G and 6G spectrum, validate a representative end-to-end beyond 5G architecture (and later 6G) including end-to-end service provisioning with slicing capabilities, and at cloud implementation level (Open RAN). Furthermore, 6G-XR shall validate multi access edge computing scenarios and their integration into a complete cloud continuum, support innovative use cases with vertical actors, beyond 5G capabilities, and support showcasing events. In addition, 6G-XR demonstrates and validates performance of innovative 6G applications with a focus on demanding immersive applications such as holographics, digital twins and XR/VR. 6G-XR will support impactful contribution to standards and demonstrate the technological feasibility of key societal requirements and objectives such as energy reduction at both platform and network levels.

Keywords: b5g,6g experimental platform,network enablers,ran enablers,holography,xr,digital twin
What does your blood remember? The memory of hematopoietic stem cells. (StemMemo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Human organism produces over a million new blood cells each second. The hematopoietic system dynamically reacts to environmental stress and forms adaptive immunity to memorize and effectively fight the encounter pathogens. However, based on our recent studies and preliminary results, we propose that the adaptive capabilities and memory of the hematopoietic system reach far beyond the classical adaptive antigen-specific immunity. We hypothesize that hematopoietic stress induces clonal expansion of lineage-biased hematopoietic stem cells (HSCs) with epigenetic memory that faster and more effectively respond to secondary stimulation with a given stress factor. We propose that lineage-biased HSCs accumulating during aging provide a broad adaptive memory of the hematopoietic system, that is not restricted to immune cells, but includes all blood cell lineages. The aim of our proposal is to understand how the HSC-stored memory is created, maintained and recalled, and to clarify the underlying mechanisms. First, we will selectively stimulate granulopoiesis, erythropoiesis and thrombopoiesis to define the specificity and physiological role of hematopoietic memory provided by HSCs, both in vitro and in vivo. Second, we will use single-cell level fate mapping and sequencing to investigate clonal and epigenetic mechanisms driving the HSCs-based memory in mice. Third, we will test if aging pool of human HSCs consists of lineage-biased HSCs that store memory of the previously encountered stimuli. The humanized mice models will determine the clonal expansion of human HSCs upon primary and secondary stimulation with stress factors. Altogether, the expected outcome of the project is to understand how and why hematopoietic system adjusts to the environmental challenges upon aging. The proposed novel concept of the hematopoietic system adaptivity may help to design strategies to train patients' hematopoiesis and improve the transplantations of HSCs.

Keywords: aging,hematopoietic stem cells,bone marrow transplantation,hematology,
FLIARA: Female-Led Innovation in Agriculture and Rural Areas (FLIARA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Ireland,Netherlands,Italy,Finland,Slovenia,Spain,Germany,Belgium,Czechia,Sweden
Call: Boosting women-led innovation in farming and rural areas (HORIZON-CL6-2022-COMMUNITIES-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2999913.75
EU funding (EUR): 2999913.5
Participants: 16
Project status: SIGNED

Key contemporary trends, such as climate change, gender inequalities and the COVID-19 pandemic, bring new challenges to European rural areas. Change also brings opportunities to foster more resilient, inclusive and sustainable rural regions, such as created by the digital and ecological transitions. However, there is a need for all individuals and communities to participate in rural innovation. Traditionally, however, rural women’s employment opportunities and contribution to innovation has been overshadowed, and often suppressed, by for example a patriarchal ethos. FLIARA (Female-Led Innovation in Agriculture and Rural Areas) uniquely proposes a transdisciplinary, innovative methodology to improve understanding, awareness and recognition of women’s role in a more sustainable rural future, as well as develop proposals for how more effective policy and governance frameworks can support this and enhance women’s capacity to contribute to it. FLIARA will combine futures and case study methods, alongside network building and policy benchmarking, while being underpinned by a co-created conceptual and assessment framework. Using a unique foresight approach, FLIARA will identify visions for sustainable farm and rural futures and the sustainability innovations needed to realise these visions. Using a thematic case-study approach, project partners will investigate women-led innovations on farms and in wider rural areas looking at their pathways in the innovation ecosystem. Building on the power of social networks, a Community of Practice will be developed with women identified throughout the case studies networking alongside key innovation policy and governance stakeholders. The Community of Practice Network will occur in conjunction with a Campaign of Visibility for women-led rural innovations, spotlighting women as key innovation actors. Project outcomes will result in end-user ready resources, including policy proposals and practical tools supporting women-led innovation.

Keywords: innovation,gender,agriculture,rural development,sustainability
circUlar Low Trophic oFfshore Aquaculture in wind farms and Restoration of Marine Space (ULTFARMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Netherlands,Germany,Belgium,Denmark,Sweden,Portugal,Ireland,Faroe Islands,Spain
Call: Lighthouse in the Baltic and the North Sea basins - Low impact marine aquaculture and multi-purpose use of marine space (HORIZON-MISS-2021-OCEAN-04, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 10312249.51
EU funding (EUR): 9590770.66
Participants: 25
Project status: SIGNED

ULTFARMS aims to move beyond the current application of Low-Trophic Aquaculture (LTA) systems with novel engineering, technical, ecological and biological processes to optimise production in harsh offshore conditions, low-salinities, and their integration within Offshore Wind Farms (OWFs). ULTFARMS will be covering the whole value chain expertise for LTA production in OWFs. Co-development and co-management by research and industry realises novel designs and operations unique to offshore in six Low-Trophic Aquaculture Pilots (LTAPs) in as many OWF locations across the North and Baltic Seas. These six pilots are implemented in: Belgium-Belwind (Seaweed-Mussels-Oysters), the Netherlands-Borssele (Mussels), Germany-FINO2 (Seaweed) & FINO3 (Seaweed-Mussels-Oysters), and Denmark-Anholt (Seaweed-Mussels) & Samsø (Seaweed-Mussels). X This approach involves stakeholders from across the value chains of OWF and LTA to ensure environmentally sound, low-carbon, and safe LTA products from design to commercialisation. New cultivation structures, grow-out systems, and both nature restoration and eco-friendly design measures are advanced through the proposed work. Drawing on existing open databases and operational forecasting systems, such as CMEMS and SeaDATANET, within integrated monitoring and management platforms, such as the HiSea service platform, the planning and operation of LTAs can be effectively supported via an enhanced technical service. ULTFARMS will offer services to aquaculture producers for monitoring and minimizing diseases and alien species, managing inputs, optimizing sustainable production and demand management including risk analysis. Furthermore, through the inclusion of 5 Associate Regions (ARs) throughout the lifetime of the project, lessons learnt and innovations developed will be shared through comprehensive communication and dissemination activities and underpinned by the ARs active inclusions in work undertaken with partners throughout the project.
The Missing Piece: Euphratesia as a Hub of Sacred Architecture within the Cultural Landscape of Late Antique Northern Syria (EASy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2026-09-30
Duration (months): 12.0
Total project cost (EUR): 81583.08
EU funding (EUR): 81583.08
Participants: 1
Project status: SIGNED

This project aims to unlock a crucial yet overlooked chapter of Late Antique history by exploring the Christian architecture of Euphratesia, a region largely forgotten in modern archaeological research. While nearby regions like Northern Syria have been extensively studied, Euphratesia remains a blank spot on the map of Late Antique scholarship. Through this fellowship, I will address this gap by conducting the first comprehensive analysis of the province’s church buildings, which played a pivotal role in the spread of early Christian practices and architecture. My research will involve recording and studying these churches, examining their construction, design, liturgical elements, and put it into context. This will not only reveal how Euphratesia connected culturally and architecturally to its neighbors like Antioch and Northern Mesopotamia, but also how it contributed to the development of Christian rituals. The project is timely, given recent discoveries in the region, and promises to provide new insights into how early Christian communities shaped their cultural landscapes. The impact will be far-reaching: it will fill a major gap in our understanding of early Christianity, contribute to the academic community. The fellowship at the University of Warsaw will expand my expertise as a leading researcher in the field and offers a unique opportunity to pioneer a study that will influence future scholarship in archaeology, religious studies, and history.

Keywords: late antiquity,sacral architecture,liturgy,byzantine archaeology,near east,northern syria,cult and society
Fostering Digital Civics Research and Innovation in Lisbon (DCitizens)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Portugal,Italy,Germany,United Kingdom
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 1074653.75
EU funding (EUR): 1074653.0
Participants: 4
Project status: SIGNED

While governments act as transactional providers of uniform and static services, the challenges of contemporary society require different models of service design and delivery that are built on long-term engagement, participation, and co-creation with local communities and citizens. Digital Civics posits the use of technology in the provision of relational models of public services by empowering citizens and non-state actors to co-create, take an active role in shaping agendas, making decisions about service provision, and making such provisions sustainable and resilient. DCitizens builds on those principles to achieve 5 main objectives: O1) Enhance ITI research profile and innovation competence in Digital Civics; O2) Provide training to Staff and Early Stage Researchers to build critical mass at the interface of research, local government, and the private/third sectors; O3) Establish a leading pole of excellence in Digital Civics; O4) Strengthen and expand the collaborative network between the Twinning partners; and O5) Establish a Digital Civics Research and Innovation Agenda in line with the SMART Specialization Strategy for Lisbon. We identified four interconnected Strategic Areas in Digital Civics to be strengthened with the Twinning partners’ support that provide solid ground to establish the methodology and action plan to reach these objectives. The Strategic Areas are: 1) Community-based Research Methods, 2) Emerging Technologies, 3) Design Justice, and 4) Civics, Policy, and Economic Models. Based on these areas, the project’s work plan includes a staff-exchange programme, organisation of joint scientific/training events, activities to enhance the profile of young researchers, training of research management staff, and a small citizen-led research project. The consortium includes partners from one widening country (ITI - Portugal), and three leading institutions in the field: IIT (Italy), University of Siegen (Germany), and University of Northumbria (UK).

Keywords: civics,digital services,digital technologies,design,human computer interaction,participatory design methods,action based research,citizen engagement,relational models,civic commissioning
Novel ultrafast fiber microlaser for applications in Microwave Photonics and Communication Networks (MicroLight)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

The presented proposal concerns the theoretical investigation, experimental realization, characterization and optimization of a novel compact ultrafast fiber microlaser (EDPPF-m) for Microwave Photonics (MWP) applications. The EDPPF-m is a nonlinear Fabry-Perot (F-P) resonator based on a novel technological platform consisting in an erbium doped periodically poled fiber (EDPPF) which combines in a single device the second and third order nonlinearities of a periodically poled fiber with the optical gain of an erbium doped fiber to generate very stable and high-power active cavity soliton pulses (and their related frequency combs). The EDPPF-m will be used as a MWP source, capable to generate electronic signals with repetition rates typical of microwaves (1 - 300 GHz) through a technique called remote heterodyning detection (RHD). The EDPPF-m will allow to overcome the drawbacks of existing MWP sources, such as fluctuations of spectral linewidth and intensity (mode-locked lasers) or low nonlinear conversion efficiency and low power handling capacity (microresonators) and will embody the ideal characteristics of a MWP source (low optical loss, tunable high repetition rate, low phase noise, high power handling capacity, high nonlinear conversion efficiency, ease of coupling with optical fibers). The proposal is divided into three work packages (WPs). The first two WPs are dedicated to the fabrication and miniaturization to the centimeter scale of the fiber microlaser proposed in two different configurations, one based on a commercial erbium doped fiber (EDF) (where only the third order nonlinearity is exploited) and the other one based on the EDPPF (where both the second and third order nonlinearities are used to generate solitons). The third WP describes the experimental procedure (RHD) adopted to implement the MWP source for applications in Communication Networks starting from the two versions of the fiber microlaser presented in the first two WPs.
Turbulence-On-a-Chip: Supercritically Overcoming the Energy Frontier in Microfluidics (SCRAMBLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

The technological opportunities enabled by understanding and controlling the microscale world have not yet been capitalized to disruptively improve energy processes, especially heat transfer and power generation. This is mainly due to the laminar flows typically encountered in microdevices resulting in low mixing and transfer rates. This is a central unsolved problem in the thermal-fluid sciences, in what some researchers refer to as lab-on-a-chip and energy - the microfluidic frontier. Therefore, the overarching goal of the SCRAMBLE project is to overcome this long-standing frontier by (i) discovering the fundamentals of inducing turbulent flow in microchips by means of utilizing high-pressure supercritical fluids, (ii) finding the critical conditions to drastically enhance and control mixing and transfer processes, and (iii) designing, fabricating and testing a disruptive first-ever series of turbulence-on-a-chip prototypes for transferring energy with a hundredfold performance improvement with respect to standard microsystems. Achieving microconfined turbulence has deep scientific and engineering implications for disruptively advancing microfluidic-intensive applications, like for example in chemistry and biomedicine, and to open a new research avenue to develop and apply groundbreaking turbulent flow solutions to microfluidic energy conversion and power generation technologies (these consume an aggregated 70% of the European Union?s energy). In the medium- to long-term future, the technology proposed could enable (i) the efficient miniaturization of thermodynamic cycles for power generation, (ii) reconceptualization of the next-generation of computer processors based on remarkably powerful microfluidic-based cooling, and (iii) the adoption of novel microfluidic solutions in fuel cells for transportation and propulsion. These advances, together with many other potential breakthroughs, could help drive the transition toward a greener energy economy.

Keywords: microfluidics,supercritical fluids,turbulence
Chemical biology of intracellular cholesterol transport (ChemBioChol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499786.0
EU funding (EUR): 1499786.0
Participants: 1
Project status: SIGNED

Cholesterol transport proteins (CTPs) regulate cellular metabolism, hormone biosynthesis, and organelle contacts, with profound consequences for human health and disease. Despite this, almost no small molecule CTP modulators have been reported, and no methods for determining selectivity across the broader protein class exist. Selective CTP inhibition is conceptually challenging as all CTPs are structurally similar and bind cholesterol. Furthermore, due to redundancy among several CTPs, deciphering the biological roles of their individual cholesterol transport activity has been difficult. ChemBioChol aims to unravel the functions of individual CTPs by developing selective small molecule modulators. Based on seminal work from my lab, I propose employing a sterol-inspired compound design strategy consisting of a primary sterol fragment as “anchor” for CTP binding, fused to secondary natural product fragments to engineer selectivity of the compounds for individual CTPs. My group will develop bio-physical and -chemical tools to determine lipid selectivity of CTPs and optimise selective molecules against them. Preliminary data on the Aster CTP family provides a proof-of-principle that selective and potent chemical tools are attainable, and that the concept is applicable to further CTP families. To determine cellular selectivity of CTP inhibitors against all cholesterol-binding proteins, I will also develop a mass spectrometry-based chemical proteomic approach with a universal cholesterol probe. Optimised CTP inhibitors will be used to determine how CTPs mediate lipid metabolism and trafficking, and their effect on sterol-mediated processes including mTOR signaling and autophagy, with potential applications in neurodegenerative disorders and cancer. A general approach for selectively modulating CTPs is ground-breaking and will have impact beyond this set of proteins by providing a blueprint for studying and targeting other families of lipid-binding proteins in the future.

Keywords: cholesterol transport proteins,lipids,natural products,tool compounds