Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cellular and molecular regulators of the pleiotropic activities of gamma delta T cells in the tumor microenvironment (GammaDeltaTME)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2021-01-15
End date: 2023-01-14
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Immune cells constitute a major component of the tumor microenvironment (TME) that influence several aspects of cancer progression and outcome. The host laboratory has identified two distinct γδ T-cell subsets with opposing roles in tumor progression: whereas interferon-γ (IFN-γ)-producing γδ T-cells stimulate anti-tumor responses, IL-17A-secreting γδ T-cells promote angiogenesis and tumor growth. However, the cellular and molecular factors controlling the critical balance between these antagonistic subsets remain unknown. The present proposal builds on subsequent relevant findings of the host laboratory, namely that neutrophils suppress IL-17A+ γδ T-cell proliferation, revealing an unanticipated neutrophil/γδ T-cell crosstalk in TME, and that on another side the metabolic resources may also play a critical role in γδ T-cell subsets. Based on these foundations, within the present proposal we will: a) identify TME cellular partners that determine the balance between IFN-γ+ and IL-17A+ γδ T-cells in several experimental models of cancer. b) study the metabolic pathways employed by γδ T-cell subsets and the impact of manipulating those pathways on their balance within the TME c) analyze the impact of immune crosstalk and metabolic resources on γδ T-cell subsets both at transcriptomic and epigenetic levels. Overall, this project will provide conceptual advances that will foster innovative strategies to promote anti-tumor γδ cell functions at the expense of their pro-tumoral activities.
Care of the Self and Ethics for the Other: From a Genealogy of Asceticisms to the Critique of the Subject (MSCALI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

This fellowship will draw together Western and Chinese theories and literatures to develop a truly comprehensive genealogy of asceticism, and will explore how this expanded understanding of ascetic practice can enhance contemporary therapeutic practices. It will examine the relationship between the idea of the “care of the self,” whose early Western genealogy was explored by 20th Century thinker Michel Foucault, and an ethics of concern for the other as developed in Chinese traditions, with a view to surmounting the solipsism that seems to plague Foucault’s ethics of transgression. This fellowship will be hosted by Royal Holloway University of London (RHUL) under the supervision of Prof. Nathan Widder.

Keywords: asceticism,care,self,other,subjectivity,psychotherapy
Extremes in logarithmically correlated fields (LogCorrelatedFields)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-06-01
End date: 2022-06-30
Duration (months): 73.0
Total project cost (EUR): 1292500.0
EU funding (EUR): 1292500.0
Participants: 1
Project status: CLOSED

The proposed research deals with the extremes of logarithmically correlated fields, in both the Gaussian and non-Gaussian setups. Examples of such fields are branching random walks, the (discrete) two dimensional Gaussian free field, the set of points left uncovered by a random walk on the two dimensional torus at times close to the cover time of the torus, the (absolute) values of the characteristic polynomial of random matrices, Ginzburg-Landau models, and more. The proposal builds on recent progress in the study of the maximum and of the extremal process of the two dimensional Gaussian free field, which was made possible by Gaussian comparisons and the introduction of a refined version of the second moment method. The proposed research will develop the tools needed for building a general and flexible theory applicable to general logarithmically correlated fields. Applications to the multiplicative chaos will also be considered.

Keywords: logarithmically correlated fields gaussian free field extremal process
Mapping Interoperable EU PPDR Broadband Communication Applications and Technology (BROADMAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Germany,Spain,Ireland,Italy,Israel,Finland,Bosnia and Herzegovina,Norway,Belgium,Finland,Romania,Sweden,Sweden,Greece,Croatia,France,Netherlands
Call: Communication technologies and interoperability topic 1: interoperable next generation of broadband radio communication system for public safety and security (H2020-DRS-2015, 2015)
Start date: 2016-05-01
End date: 2017-04-30
Duration (months): 12.0
Total project cost (EUR): 2169138.0
EU funding (EUR): 2169137.5
Participants: 21
Project status: CLOSED

The BROADMAP project will take the first steps towards future procurement of ‘interoperable next generation of broadband radio communication systems for public safety and security’ (DRS-18) to improve PPDR’s service to Europe’s citizens and enhance interoperability across borders. The primary goal of this project is to: Collect and validate the PPDR (Public Protection and Disaster Relief) organisations’ existing requirements with the aim to establish a core set of specifications, and roadmap for procurement, to achieve future evolution of EU broadband applications and interoperable radio communication solutions This project implements a Coordination and Support Action (CSA) with the purpose to inform and guide the future procurement of research and development, networks and devices and their deployment to realise new interoperable broadband networks, and the ecosystems of applications and services to support the PPDR and critical communications community. Project BROADMAP addresses the following goals: – To collect, assess and validate the PPDR’s wireless broadband communication requirements – To establish a core set of specifications to fulfil the requirements – To define transition roadmaps for research and standardisation for future evolution of European interoperable radio communication solutions, within legal procurement constraints – To prepare the ground for a new eco-system to catalyse new applications, services and processes making use of broadband capabilities for public safety and security – To utilise the strength of the PPDR community through our partners, their expertise, knowledge, networks and relations with the aim to achieving interoperability across Europe. This importantly includes nuances of societal differences, including different cultures, geography, processes and legal frameworks BROADMAP integrates 15 potential buyers/end users from 15 countries, 8 of which are responsible ministries. 48 further end users provide initial support.
Trade Agreements and Supply Chains (TRASC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Belgium,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 1817096.25
EU funding (EUR): 623942.16
Participants: 2
Project status: SIGNED

Recent decades have witnessed two major trends in international trade. The first is the increasing fragmentation of production processes across countries: advances in information and communication technology and falling trade barriers have allowed firms to retain in their domestic economies only a subset of production stages, leading to a surge of trade in intermediate goods. The second trend is the proliferation of regional trade agreements (RTAs), which have risen in number and have become “deeper”, encompassing many provisions that go beyond traditional trade policy. RTAs have contributed to the creation of regional supply chains (e.g. “Factory Europe”, “Factory North America”), shaping firms’ sourcing decisions through preferential tariffs and rules of origin. The recent backlash against RTAs, exemplified by Brexit and President Trump’s decision to renegotiate the North American Free Trade Agreement, could have dramatic consequences for supply chains in Europe and North America. I propose an ambitious research agenda that will develop new theoretical models and use exceptionally rich new data for pathbreaking analysis of the RTAs-supply chains nexus. First, I will study the impact of RTAs on firms’ sourcing decisions, productivity, and welfare, breaking from the literature on global sourcing, which neglects the role of trade agreements. Second, I will examine how large corporations with international supply chains shape the content and political support for deep RTAs, breaking from a vast literature in political economy, which studies agreements covering trade provisions only and neglects the role of firms. I will address novel and timely questions about the RTAs-supply chains nexus, emphasizing the key role played by firms and the interplay between economics, law, and politics. This is an extraordinarily high-return agenda, given the importance of understanding the consequences and determinants of trade agreements for economic policy and academic research.

Keywords: trade agreements,supply chains,firms,sourcing,tariffs,rules of origin,lobbying,voting
EXaSCale smArt pLatform Against paThogEns for Corona Virus (EXSCALATE4CoV)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Germany,Germany,Spain,Italy,Italy,Belgium,Sweden,Switzerland,Poland,Switzerland
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2021-09-30
Duration (months): 18.0
Total project cost (EUR): 2970875.0
EU funding (EUR): 2970875.0
Participants: 18
Project status: CLOSED

The EXSCALATE4CoV (E4C) project aims to exploit the most powerful computing resources currently based in Europe to empower smart in-silico drug design. Advanced Computer-Aided Drug Design (CADD) in combination with the high throughput biochemical and phenotypic screening will allow the rapid evaluation of the simulations results and the reduction of time for the discovery of new drugs. Against a pandemic crisis, the immediate identification of effective treatments have a paramount importance. First, E4C will select through the EXSCALATE platform, the most promising commercialized and developing drugs safe in man. Second, select from >500 billion molecules new pan coronavirus inhibitors. The huge computational resource, therefore the activities will be supported and empowered by three of the most powerful computer centers in Europe: CINECA, BSC and JÜLICH. The Swiss Institute of Bioinformatics (SIB) will provide the homology 3D models for the viral proteins. The Fraunhofer IME will provide the BROAD Repurposing Library and biochemical assays. Phenotypic screenings will be run by KU LUEVEN to identify molecules capable of blocking virus replication in in vitro models. IIMCB and ELECTRA will determine the crystal structure of at least one coronavirus functional proteins to evaluate the structural similarities with other viral proteins. EXSCALATE4CoV consortium will identify safe in man drugs repurposed as 2019-nCoV antiviral and will propose to the EMA innovation task force (ITF) to define a preliminary development strategy and a proposal for a registration path. The E4C project will share promptly its scientific outcomes with the research community by using established channels: ChEMBL portal for the biochemical data, the SWISS-MODEL portal for the homology models of viral proteins WT and mutants, the Protein Data Bank for the experimentally resolved protein structures, the EUDAT for the data generated by in-silico simulations and the E4C project website.

Keywords: coronavirus,drug design,drug discovery,drug repurposing,biochemical screening,phenotypic screening,structural biology,crystallography,cryo em,mechanism of action,genomics
Environmental subjects, conflicts and commodity frontiers (ASUNDER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

The fellowship aims at establishing the applicant an expert in the study of environmental conflicts through training in the interdisciplinary fields of political ecology and environmental history at the University of Wisconsin-Madison (UW). Training will consist in courses on environmental history at the Centre for Culture, History & Environment and research under the guidance of the Nelson Institute for Environmental Studies Director Prof Paul Robbins. The research project will mobilise political ecology theory on environmental subjects and environmental history research methods to investigate the understudied phenomenon of acceptance of environmental harm occurring in the course of environmental conflicts. This will be examined through a case study of a conflict over silica sand mining – an activity necessary to obtain sand for use in the controversial process of shale gas extraction (fracking) – in Wisconsin, the larger silica producer in the US. The project will advance theory and analysis of ecological distribution conflicts. The fellow will benefit from interactions with UW’s Geography department political ecology experts and complementary skills training in science communication via digital media technologies (podcasts) and radio. The fellow will expand his network and expertise by attending specialised seminars and benefit from UW’s world-class library facilities. Project findings will be integrated in European research networks working on environmental conflicts, ecological economics and political ecology and contribute to making the European Research Area a centre of excellence in those fields. Knowledge from the outgoing period will be reintegrated in the Institute of Environmental Science & Technology of Universitat Autònoma de Barcelona through postgraduate teaching and supervision, and by establishing a distinctive line of research on subjects and environmental conflict. Long-term collaboration between host institutions is envisaged through the project

Keywords: environmental conflict,political ecology,environmental history,mining,silica sand
Rapid Data Communication Network for Connected Cars (CarNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2018-03-31
Duration (months): 36.0
Total project cost (EUR): 1917731.0
EU funding (EUR): 1342411.7
Participants: 1
Project status: CLOSED

Demand for data in cars has grown at a rapid rate. Connected cars now want to communicate between the different areas of the car to understand the status of the car, the environment around it and then communicate this information to the driver. Many Advanced Driver Assisted System applications wish to make use of this data to support the driver to drive safely and to save lives. However, current in-car data communications networks cannot supply this day in a fast, reliable way so that it can be used. The physical environment of the car is challenging, with vibrations, heat and Electro Magnetic interference all meaning that traditional communications networks are unsuitable. They are also not capable of reaching above speeds of 150Mbps, meaning all information is too slow to be useful. KDPOF has developed and patented a breakthrough low-cost technology which allows data transmission at rates of up to 1Gbps. Furthermore, as this technology uses Plastic Optical Fiber, it overcomes all the challenges of the in-car environment. KDPOF have recently launched this product for the consumer and professional markets. The CarNet project aims to support KDPOF to adjust, test and demonstrate the benefits of KDPOF’s Giga technology to the Automotive market. As this market is complex, with a long product development process, the CarNet project will also look to understand fully the business strategy to ensure that the product’s commercial potential is maximized and to ensure that KDPOF is at the forefront of developing the standards that will shape the future in-car data communications market. As a result of this project, KDPOF will grow considerably, doubling their employees by five years after the project and earning a return on investment of over 80%. It will also reduce the costs of in-car data communication networks and improve the competitiveness of the European Automobile sector in general, and the in-car data and ADAS sector in particular.

Keywords: plastic optical fiber,smart car,communication network,ethernet,data transmission,gigabit technology,automotive sector,standardisation,validation,advance driver assistance service
Plasmonic Enhancement and Directionality of Emission for Advanced Luminescent Solar Devices (PEDAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-09-30
Duration (months): 78.0
Total project cost (EUR): 1447410.0
EU funding (EUR): 1447410.0
Participants: 1
Project status: CLOSED

Applying photovoltaic (PV) panels to buildings is an important application for wider PV deployment and to achieving our 20% Renewable Energy EU targets by 2020. PEDAL will develop a disruptive PV technology where record increases in efficiency are achieved and costs dramatically reduced; (1) Diffuse solar radiation will be captured to produce higher efficiencies with concentration ratios over 3 in plasmonically enhanced luminescent solar concentrators (PLSC). Current LSC efficiency achieved is 7.1%, [1]. This proposal will boost efficiency utilising metal nanoparticles (MNP) tuned to luminescent material type in LSCs, to induce plasmonic enhancement of emission (PI and team have achieved 53% emission enhancement). MNP will be aligned to enable directional emission within the LSC (being patented by PI and team). These are both huge steps in the reduction of loss mechanisms within the device and towards major increases in efficiency. (2) Plasmonically enhanced luminescent downshifting thin-films (PLDS) will be tailored to increase efficiency of solar cells independent of material composition. MNP will be used, where the plasmonic resonance will be tailored to the luminescent species to downshift UV. MNP will be aligned to enable directional emission within the PLDS layer, reducing losses enabling dramatic increases in a layer adaptable to all solar cells. (3) These novel systems will be designed, up-scaled and a building integrated component fabricated, with the ability not only to generate power but with options for demand side management. Previous work has been limited by quantum efficiency of luminescent species, with this breakthrough in both the use of MNP for plasmonic emission enhancement and alignment inducing directionality of emission, will lead to efficiencies of both PLSC and PLDS being radically improved. PEDAL is a project based on new phenomena that will allow far reaching technological impacts in solar energy conversion and lighting.

Keywords: solar energy systems
Scalable Quantum Photonics with Ultra Bright Photon Sources (SQuaPh)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The development of quantum networks relies on true single-photon sources and deterministic quantum logic gates. Photons are the most promising flying qubits, capable to propagate long distances without decoherence. However, until now, quantum communications protocols and optical quantum computation have been implemented using defective single-photon sources and probabilistic quantum gates. For a long time, the best single-photon sources have been heralded non-linear crystals where photon-pairs are generated. Such sources can present high coherence properties although they are intrinsically limited to a very low photon flux. This project builds up on major steps obtained in the host team, Laboratoire de Photonique et de Nanostructures, in terms of true single-photon generation and control. By deterministically inserting a quantum dot (QD) in a semiconductor microcavity pillar, the host team fabricated photon sources with quantum properties as good as the currently used sources, but with an unprecedented brightness of 2 orders of magnitude larger. The cavity not only enhances the interaction of the incident photons with the QD state but also the subsequent photon extraction of the device. The Purcell effect diminishes the decoherence processes, constituting an ultrabright source of highly indistinguishable, single-photons. Based on the unique technological, experimental and conceptual knowledge developed by the host team, and on the background of the applicant, our successive objectives is to realize scalable quantum entanglement: to entangle two-photon states with our ultrabright QD-cavity systems at high rates, to use them to perform high fidelity teleportation with long coherence times between 2 different sources, and finally to controllably swap the entanglement between 2 entangled photon-pairs.

Keywords: solid state quantum networks,linear quantum optics,generation and distribution of entanglement