Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sensor based adaptive laser micromachining using ultrashort pulse lasers for zero-failure manufacturing (ADALAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Sweden,Switzerland,Netherlands,Netherlands
Call: Process optimisation of manufacturing assets (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 4201510.0
EU funding (EUR): 3764635.0
Participants: 19
Project status: CLOSED

Miniaturization, advanced high performance materials and functional surface structures are all drivers behind key enabling technologies in high added value production. It is in such areas that ultrashort pulse lasers have enabled completely new machining concepts, where the big advantages of laser machining are combined with a quasi non-thermal and therefore mild process, which can be used to machine any material with high precision. An important obstacle however that hinders the full exploitation of the unique process characteristics, is the lack of a smart / adaptive machining technology. The laser process in principle is very accurate, but small deviations, e.g. in the materials to be processed, can compromise the accuracy to a very large extend. Therefore feedback systems are needed to keep the process accurate. Within this project the goal is to develop an adaptive laser micromachining system, based on ultrashort pulsed laser ablation and a novel depth measurement sensor, together with advanced data analysis software and automated system calibration routines. The sensor can be used inline with the laser ablation process, enabling adaptive processes by fast and accurate 3D surface measurements. The integrated sensor can be used to: • measure the surface topography while machining a part, in order to adapt the micromachining process, leading to highly increased machining accuracies and no defects, • measure the surface topography before machining, to scan for existing surface defects that can be removed in an automatically generated machining process, • measure complex shaped objects prior to machining, to precisely align the machining pattern to the workpiece, • quickly validate results after machining. Therefore, the main objective of this project is to develop a sensor based adaptive micro machining system using ultra short pulsed lasers for zero failure manufacturing.

Keywords: ultrashort pulsed laser ablation,manufacturing,3d analysis,micro manufacturing,zero defects,micromachining,in line,topography sensor,adaptative process
The ER located master regulation of endosomal positioning and further movements (ERCOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2383625.0
EU funding (EUR): 2383625.0
Participants: 1
Project status: CLOSED

The endo-lysosomal system is critical to diverse processes, including protein homeostasis, signaling and antigen presentation. The vesicular compartment is organized as a collective unit wherein the bulk of endosomes derived from disparate origins resides in a cloud in the perinuclear region and extends outwards to include quickly moving vesicles in the periphery. At this busy intersection between the endocytic and biosynthetic pathways, lies the late endosomal compartment, responsible for protein degradation and antigen processing. In dendritic and other immune cells, this major constituent of the perinuclear cloud serves as a hub for MHC class II antigen loading. Previous work by us and others has elucidated key elements of MHC class II biology through the study of late endosomal transport to and from the cell periphery. It is clear that cell biology of endosomes is modulated by their proximity to other membrane compartments during transport, maturation, cargo selection and delivery and even during cytokinesis in cell division. However, how endosomal positioning in the perinuclear cloud and how their release for further transport is controlled remains largely unknown. The aim of this proposal is to define the molecular basis for endosomal positioning and then to interrogate the relationship between spatial regulation of the endocytic compartment and its functions with respect to i) MHC class II antigen presentation, ii) bacterial infection and iii) mitotic resolution. From a genome-wide siRNA screen for factors influencing MHC class II biology, we have identified a unique and previously uncharacterized ubiquitin ligase that resides in the ER membrane, from where it controls endosomal positioning and times their arrivals and departures as a function of its catalytic activity. On this basis, the work proposed herein is poised to resolve an entirely new molecular network in control of endosomal biology with implications for diverse biological processes.

Keywords: endosomal positioning,vesicle transport,mhc class ii
Metabolites as immunomodulatory additives for biomaterials (Met4Bone)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Latvia
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 152202.24
EU funding (EUR): 152202.24
Participants: 1
Project status: CLOSED

The biomaterials are crucial for the surgical remediation of bone defects caused by various diseases e.g. osteoporosis and traumatic fractures. However, there are several risks associated with this treatment; first, the surgical procedure itself carries a potential risk of inflammation and bone infection, second, the bone replacement can fail requiring revision surgery. In fact, the host immune response to implanted materials and devices is the main factor that will determine a long-term functional outcome of the biomaterial mediated treatment. Therefore, the bone biomaterial ability to modulate the local immune environment for favorable treatment outcomes has to be considered. The usage of bioactive metabolites has emerged as one of the most novel and potent approach for immune response modulation. The incorporation of metabolites with immune regulatory properties seems an especially attractive option for biomaterials as it would ensure site-specific delivery system and allow modulation of the microenvironment. The goal of this project is to develop novel biomaterials with incorporated metabolites as a potentially effective and safe strategy to modulate local immune response towards favorable outcomes of surgical bone remediation. To achieve it, the recent concept of metabolomics with the state of the art biomaterial design and research will be combined in this project. This proposal includes the transfer of knowledge to the host institution and the training of the researcher in new techniques and skills. The multidisciplinary nature of the project is strong, combining materials science, biochemistry, and molecular biology. Results have the potential to pave the way for novel biomaterials significantly improving clinical outcomes for patients suffering from bone injuries.

Keywords: bioceramics,metabolite,immune response
Fluvial Meta-Ecosystem Functioning: Unravelling Regional Ecological Controls Behind Fluvial Carbon Fluxes (FLUFLUX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Austria,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1487171.0
EU funding (EUR): 721821.2
Participants: 2
Project status: SIGNED

Fluvial ecosystems are an important element in the global carbon cycle metabolizing large amounts of terrigenous organic matter (tOM). This contributes to CO2 evasion fluxes that are under continuous reevaluation at the global scale. In contrast, research on the underlying processes is concentrated at the local ecosystem scale. This scale-gap seriously hampers process understanding across scales, limits upscaling accuracy, and reduces our scope of reaction strategies. Here, I suggest ground-breaking research on ecological processes at the intermediate ‘regional’ scale of the ‘fluvial network‘ to create a deeper mechanistic understanding of biogeochemically relevant carbon fluxes. My starting point is trifold: (1) detrital tOM has extremely high molecular-level diversity that requires consumers of equally high biodiversity for efficient respiration; (2) exactly this biodiversity of heterotrophic microbes, fungi and insects is constrained by metacommunity dynamics unfolding at a larger regional scale; and (3) the rules by which the conspicuously dendritic structure of the fluvial network shapes a metacommunity differ fundamentally from those governing regional diversity patterns of tOM resources. I hypothesize regional carbon dissimilation in ‘fluvial metaecosystems’ to be the interactive product of spatially partitioned resource and consumer diversities. I posit that this coupling of metacommunity structure to metaecosystem function is influenced by fluvial network topology, anthropogenic network fragmentation, and terrestrial matrix variation. Research will combine experiments in innovative lab-scale metaecosystems, spatially explicit modelling using cellular automata, and field studies spanning gradients of regional anthropogenic impact in real fluvial networks. I expect this cross-disciplinary research at the crucial landscape scale to generate novel mechanistic process understanding behind fluvial carbon fluxes in a world changing at ever faster pace.

Keywords: metacommunity,metaecosystem,limnology,biodiversity,spatial ecology
Slavery, Work and Freedom: What Can Cash Transfers Contribute to the Fight for Decent Work? (WorkFREE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: India,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499203.0
EU funding (EUR): 1239953.0
Participants: 3
Project status: SIGNED

WorkFREE builds on the widespread empirical observation that everywhere people who are stuck in indecent, exploitative or ‘unfree’ work nevertheless choose that work because doing so represents their best available option, and asks a simple yet potentially revolutionary question: What happens if we just give them money? It will answer this question by creating a world-first social experiment. This will involve a community in the Indian city of Hyderabad typically associated with indecent or exploitative work – waste picking. Members of this community will receive 18 months of unconditional cash transfers (UCTs) and also engage in Participatory Action Research (PAR) with the WorkFREE team. WorkFREE will thus become the first project anywhere to combine research on cash transfers (CTs), PAR and labour (un)freedom. It will also innovate methodologically, employing a unique combination of ethnography, surveys, and participatory qualitative techniques. This will allow the WorkFREE team – myself (the PI), the in-country Research Manager, a post-doctoral evaluation specialist, two anthropology PhD students, and a number of junior researchers at the project’s Indian partner research university – to answer a question at the heart of the UN Sustainable Development Goals (SDGs): What can cash transfers contribute to the fight for decent work? It will further enable the co-creation of grounded theory around concepts central to the SDGs, including freedom, slavery, consent, coercion, vulnerability, exploitation, emancipation and (in)decent work. This, in turn, could call into question prevailing, hegemonic theorisations of these concepts, along with mainstream approaches to generating those theorisations and the policies with which they are associated. In this way, WorkFREE will push the empirical, theoretical and political boundaries at the intersection of development studies, labour studies, social theory and social policy. Given its focus and approach, it will also contribute to cognate debates around Social Protection (SP) and Unconditional Basic Income (UBI), positioning Europe at the forefront of contemporary efforts to achieve social justice in globalised market society.

Keywords: modern slavery,unconditional cash transfers,participatory research,unfree labour,labour exploitation,social experiment,development,sdg 8
Next-generation control system to enhance performance of commercial fishing trawlers (SMART TRAWLING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Trawl fishing is one of the most common commercial fishing techniques in the world. Large nets are towed behind a boat and catch massive amounts of fish before being pulled onto the vessel. However, this technique has major drawbacks for those companies using it: as the movement of the nets is extremely difficult to control, captains are required to drastically change the vessels movement and continuously adjust winch control knobs to accommodate the nets position. Thus, they cannot focus efforts on guiding ships, and as a result, there is a waste of fuel in unnecessary, inefficient manoeuvres, and damage to the equipment, which requires constant maintenance. Moreover, the poor ability to control trawl placement also has a negative impact on the environment, as the nets catch unwanted fish or disturb the ecosystems, (e.g. when trawl nets touch the ocean floor as controls do not adjust to maintain a specific depth). Hence, there is a global need for better tools to control trawl nets and vessels in an efficient manner. We, Naust Marine ehf, count with 24 years of experience in the design and development of winch and trawl control systems for fishing vessels. Our latest development is Smart Trawling, an intelligent control platform that will help address the problems of current trawlers. Smart Trawling utilizes 18 data inputs from the trawl net, vessel, and winches to automatically adjust the nets and vessel to the optimum operating conditions. In this way, with the automated control of Smart Trawling, vessels run more efficiently, without wasting time or fuel compensating for missing the targeted fish or fighting ocean currents: Iceland’s Ministry of Environment determined a 15% reduction of fuel consumption for vessels using Smart Trawling. Additionally, trawling equipment like winches and cables will last longer due to the active management of their forces. With Smart Trawling, European companies will be able to compete in the global fishing industry.

Keywords: trawler,trawling,trawl,control,fishing,vessel,nets,smart,fuel consumption
KINETICfinder: A disruptive method to determine kinetic profiles in drug discoveries (KINETICfinder)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bringing Bringing a new drug to the market costs 2,600 M€ and it takes 12 years. In addition, around 80% of drugs under research do not reach clinical trials (due to toxicity or lack of efficacy). ENZYMLOGIC was created with the aim of being a company in the niche of kinetic analysis. They have developed KINETICfinder: an experimental, robust, accurate and reproducible methodology that provides drug kinetic analyses in a massive way and at affordable cost, so it is possible to utilise it in early research stages, when thousands of drugs are involved. ENZYMLOGIC has been focused on providing auxiliar external analysis having pharmaceutical companies as customers. Nowadays, there are no comparable technologies capables of generating this amount of information with this level of processivity (number of drugs analysed at the same time). Currently, this analysis is extremely slow and costly, thus it is carried out in the final stages of the research, with just a small number of drugs. Otherwise, the number of different drugs they can analyse is 10 times higher and 10 times faster than other kinetic analysis (processivity). KINETICfinder can reduce the time and cost by 50% from the research phase of a new drug to the market phase. KINETICfinder already makes it possible to analyse 30 kinase targets (involved in cancer), and the next step is to work with GPCRs (neurodegenerative disorders, inflammation, pain, cardiovascular diseases and diabetes). 40% of the existing drugs are aimed at GPCRs. ENZYMLOGIC has obtained several prizes recognizing innovation and potential growth. The objective in phase I will be the validation of the use of KINETICfinder for working with GPCRs having as a base the previous work performed with kinases. To achieve this, the associated tasks shall be: validation of the method working with GPCRs having as a base the previous work performed with kinases, detailed market study & business plan elaboration and validation of commercialization strategy.

Keywords: drug discovery,kinetics,residence time
Modelling the Influence of Cannabinoids on the Embodied Mind (CANNABODIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1498192.0
EU funding (EUR): 1498192.0
Participants: 1
Project status: SIGNED

The world is in the midst of a cannabis craze. After decades of criminalization, cannabinoids such as tetrahydrocannabinol (THC) and cannabidiol (CBD) are suddenly everywhere – in new medicines, in the media, and even in food and cosmetics. But how do cannabinoids influence our brain and body? Much of what we currently know about these compounds comes from neurobiological studies of the endocannabinoid system in animals. Additionally, clinical research suggests that cannabinoids offer promising new treatments for mood and affective disorders, addiction, chronic pain and fatigue, and inflammatory illnesses. However, little is known about how these compounds influence the neural or embodied processes which underlie conscious feelings of emotion, pain, or motivation. This not only limits our ability to design effective cannabinoid-based treatments, but also to negotiate the rising influence of cannabis in our society. To address this gap, in this project I will develop a novel interoceptive self-inference framework which explains how cannabinoids alter the neural mechanisms underlying our embodied and affective selves. To do so, I will use a combination of computational modelling, neuroimaging, subjective measures, and physiological recordings to map the influence of cannabinoids on brain-body interaction in four key psychological domains: interoception, emotion, motivation, and pain. This will enable me to reveal the computational mechanisms by which cannabinoids influence each of these domains. Further, by pooling data across all projects, I will deliver the largest single neuroimaging study of cannabinoid mechanisms to date. This project will answer questions such as: what is the computational basis of cannabinoid effects on brain and behavior? Do THC and CBD exert opposing or complementary effects on neural and visceral signals? What are the exact phenomenological effects of these drugs, and do they depend on idiosyncrasies in brain-body dynamics?
Prostate cancer diagnostic assay based on protein kinase activity profiling in exosomes (ProCanEx)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Estonia
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the innovation project is the development of novel biomarker-based non-invasive assay for prostate cancer (PCa) detection. 417 000 Europeans were diagnosed with PCa in 2012, about 12% of all new cancer cases of European men. The diagnosis and screening of PCa totalled 12 billion USD in 2012 and will reach 17.4 billion USD in 2017 since the PSA test is performed for men over 50 years of age annually. The PCa diagnostics market is mainly covered by the Prostate-Specific Antigen (PSA) test, the practicality of which is debated. The low specificity of the test means a high number of false positives, leading to unnecessary and painful procedures (biopsies, treatment, etc.). More than 45 million PSA tests are performed annually worldwide, while more than 9 million of those are positive, with around 70% false positives. Our assay is built on an innovative technological platform based on quantitative profiling of protein kinases in circulating exosomes. Recent scientific literature supports the potential of exosomes as diagnostic markers. Our assay combines two innovative approaches - newly discovered changes in exosome composition in cancer and probes for measuring altered levels of several protein kinases in exosomes originating from the cancer tissue. We will use the phase I of the SME instrument to make a detailed business plan, market research and evaluate technological, technical and practical issues. Collaboration with a potential licensee and complementary sources of financing for Phase II are sought. A detailed research plan will be conducted. Cancer diagnostics is among the main concerns for healthcare as cancer is among the deadliest diseases. Our proposal aims at development of innovative, non-invasive, highly reliable and cost-effective test for PCa, which would contribute to the sustainability of European health care system. Our strategy will enable patient stratification and/or prognosis of disease leading to the improved clinical decisions.

Keywords: prostate cancer,in vitro diagnostics,protein kinase,exosome,assay,pca3