Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coiled-coil mediated exonuclease tethering technology for the enhancement of CRISPR gene editing (CCedit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Slovenia
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The discovery and implementation of CRISPR technology represents a milestone for biotechnology and life sciences in general as the genomes of virtually all organisms can be modified by this technology and have already resulted in billions of euros of added value. With this technique, selected genes can be rather easily inactivated (knock out), which is one of the key applications of CRISPR for cell-based therapy and industrial biotechnology. Any improvement of the efficiency of CRISPR therefore has very high value and potential impact. Recently we designed Cas9 DNA targeting and cleavage complex to be tethered to the ExoIII exonuclease via an engineered coiled-coil (CC) dimer, developed in the ERC AdG project MaCChines. We found that it strongly improved inactivation of target genes, even better than direct genetic fusion of Cas9-ExoIII. Since this invention has a substantial translation potential we recently filed a patent application (priority number EP19192490). The strategic frontier of CCedit is to maximise the value of this enhancement of Cas9/CRISPR technology and establish the innovation potential arising from the ERC project MaCChines in the pre-demonstration phase. Specific objectives are to: • Refine the components of the CCedit technology and its implementation for specific applications; • Establish technological viability and its placement within the framework of Cas9/CRISPR technology; • Demonstrate and select most promising implementations of this technology for applications; • Investigate the IP, FTO and policy regulations landscape and further develop the IP portfolio; • Develop the business plan and commercialisation strategy for the technology; • Disseminate information on this technology and raise the interest of companies and other potential users of this technology and obtain links to early stage funding. • Train members of the project team and local community on entrepreneurial skills in biotech

Keywords: crispr,gene editing,designed proteins,synthetic biology,coile coil dimer
Genomic Selection for Potato Improvement (GenSPI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-21
End date: 2017-09-20
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Ireland produces potatoes locally to satisfy its indigenous crisping industry. However, over 50,000 tonnes of potatoes still need to be imported each year due to problems with the long term storage of locally produced product. Potatoes destined for crisping are normally stored at 8 degrees, below this glucose accumulates leading to very dark fry colours and potential acrylamide build up. Unfortunately, sprouting occurs above 8 degrees and impacts product quality. This necessitates the use of sprout suppressant chemicals such as chlorpropham. The EU is moving to phase out the use of such chemicals due to health concerns, and it is therefore necessary to develop potatoes that can be stored below 8 degrees without suffering from low temperature sweetening (LTS). LTS is under polygenic control and therefore challenging for traditional breeding programmes, particularly when it needs to be combined with other traits such as yield and disease resistance. This is where new breeding methodologies such as genomic selection (GS) can assist traditional programmes. GS is a form of marker assisted selection that simultaneously estimates all loci, haplotype, or marker effects across the entire genome to calculate Genomic Estimated Breeding Values (GEBVs). GEBVs are then used to select individuals for advancement in the breeding cycle without direct phenotyping. GEBVs for characteristics such as resistance to LTS would radically enhance potato breeding and lead to the development of more suitable processing varieties. This proposal involves directly aligning a pilot GS programme to a traditional breeding programme to evaluate the potential for GS in potato breeding. We envisage that GS will enable the screening of an extremely large number of individuals at a seedling stage, ensuring that only the most valuable material is advanced for extensive and expensive phenotyping. This will enable a dramatic increase in the genetic progress for the development of improved potato varieties.

Keywords: plant breeding,genomic selection
IND2016: KETs as drivers for the future of industry (IND2016)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Coordination and support actions
Countries involved: Netherlands,Netherlands,Netherlands
Call: Presidency events (H2020-NMP-CSA-2015, 2015)
Start date: 2015-07-01
End date: 2016-10-31
Duration (months): 16.0
Total project cost (EUR): 1112838.75
EU funding (EUR): 623000.0
Participants: 6
Project status: CLOSED

The European Key Enabling Technologies (KETs) strategy is important for the European global competitiveness, the creation of jobs and the European growth. Focusing on the development and valorisation of these KETs is crucial to this strategy. The industry-centred LEIT-NMBP part of Horizon 2020 is instrumental to the support of four of the six KETs: Nanotechnologies, Advanced Materials, Biotechnology, Advanced Manufacturing and Processing. The Work Programme (2016-2017), LEIT-NMBP focus on the valorisation of KETs. One of the activities supported by the European Commission are “events of a major strategic nature” such as conferences organised within the framework of the EU presidencies to create better synergy between initiatives launched by the Commission and by the Member States. This proposal is developed within the framework of the Dutch EU-Presidency (2016) and aims at the organisation of an international conference on Industrial Technologies. The main focus of the conference is the impact of KETs on the future of industry, that emphasizes the application of new and innovative technologies in the field of manufacturing to prepare the European industry for the future. Within this conference, the Dutch strategy on Smart Industry will act as the focal point to enhance the momentum to enter into a new manufacturing era in Europe. The overall aim of the conference is to co-develop the European agenda for the new industrial revolution and review the EU research agenda(s), to enhance the competitiveness of the European manufacturing industries. The conference will be held in the Netherlands in 2016 and last 3 days with an expected number 1250 participants over 30 nationalities from divers target groups (research, industry, private investors, policymakers and education). Specific attention will be paid to stimulate the gender balance at the conference and within the target groups. The conference will be international with an EU wide geographical spread.

Keywords: smart industries,conference
Monitoring platform for scoliosis treatment to empower kids, parents, physicians and orthotists (ScoliosisManager)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scoliosis is a three-dimensional (3D) deformity of the human spinal column and ribcage, caused by lateral curvature deviating from the midline. It has been calculated that 10% of all children have scoliosis, 2.5% requiring treatment (80% girls, 20% boys): it is of paramount importance for the health and self-esteem of these adolescents. As core of conservative treatments, braces have been used for decades with the aim of halting and possibly reversing the progressive nature of the deformity. The overall objective of ScoliosisManager is to provide monitoring mHealth services for the kids to help them to comply with the therapy: ScoliosisManager is a tool for patient empowerment and self-management of the treatment. Additionally, mHealth services are also provided to parents so that they can quickly identify non-compliant and abnormal behavioural patterns in order to provide timely help and, at the same time, a powerful tool for physicians and orthotists. As business opportunity, it is estimated a potential global market of € 252 million per year.

Keywords: spinal deformities,brace treatment,compliance,seas,mhealth,adherence to treatment,monitoring,patient empowerment,predictive model,over treatment,wearable technology,apps,sensoring
Computer Simulation of the Dissolution and Regeneration of Cellulose from Ionic Liquids (DiReC-IL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

The technological importance of cellulose, the most abundant and most widely used organic material on Earth is paramount with a very versatile range of applications. It constitutes the basis, among others, for paper and textile industries. Two emerging applications have been gaining importance and substantial attention: one is developing new fiber reinforced nanocomposites. The other novel application is as a carbon-neutral and renewable source for the production of biofuels. Due to its recalcitrance, cellulose fibers always need pre-treatment before actual applications. Traditional techniques work with harmful compounds constituting great environmental risk. In line with the Europe 2020 strategy, cheap and environmentally friendly technologies need to be promoted to achieve a more sustainable and resource efficient economy. Ionic liquids, a novel class of complex solvents with unique properties and a great potential to revolutionize chemical technologies, have been applied as dissolution media for processing cellulose, which has already led to cheaper and “greener” methods. To further develop these technologies, a thorough understanding of the molecular details of the dissolution and recrystallization processes is needed. Although considerable efforts have been dedicated to it, this has not yet been achieved. In this project we propose a new molecular simulation based approach by using enhanced sampling techniques to elucidate the molecular details of the slow and intricate dissolution and recrystallization processes. Unlike previous studies, we will start by investigating glucose and then increase the complexity of the system through larger oligomers enabling us to extrapolate our results eventually to cellulose fibers. This new systematic bottom-up approach will decrease the arbitrariness which previous studies suffered from. We expect the long-term impact of this project immense leading to new innovations and more efficient green technologies.
Algeria, antifascism, and Third Worldism: An anticolonial genealogy of the Western European New Left (Algeria, France, Italy, 1957-1975) (The Damned)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Italy,Algeria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-20
End date: 2023-01-19
Duration (months): 36.0
Total project cost (EUR): 221605.44
EU funding (EUR): 221605.44
Participants: 3
Project status: CLOSED

THE DAMNED proposes a new study of the genealogy of the New Left in Western Europe from the mid-1950s to the mid-1970s. Breaking with current interpretations, the project reframes the European political geography to include the (post)colonial space, and reassesses the historical influence of the Algerian War of Independence (1954–1962) – and Third Worldism more generally – in the genealogy of the new political cultures that flourished during the ‘long 1960s’, associating a renewed antifascism with anticolonial struggles. Bringing together disciplines and methodologies from across a number of humanities and social sciences, THE DAMNED will produce a case study (focusing on Algeria, France and Italy) setting out new approaches to understanding the emerging of the New Left as a complex process encompassing local, national and transnational dynamics; a process shaped by, but also shaping, decolonisation. The goal is to contribute – at least – to complicating the Western narrative of the global 1960s, by shifting the focus from Berkeley and Paris to Algiers. THE DAMNED is to be carried out mostly in Algeria, with a secondment in France and a return phase in Italy. Working with leading experts in each of these countries, the aim is to develop a truly transnational, interdisciplinary network exploring anew the global 1960s. By means of an extensive oral history project interviewing anticolonial activists, THE DAMNED will create a repository of sources for researchers, with a selection of interviews accessible online. THE DAMNED has been designed to ensure a mutually beneficial exchange of knowledge between the researcher and the third country (Algeria): ‘The challenge is to improve the design of cultural experiences by enhancing participatory and collaborative approaches and by fostering mutual cultural understanding and resilient strategies’, as stated in the H2020 Work Programme 2018–20.

Keywords: global 1960s,algerian war of independence,new left,antifascism,anticolonialism,third worldism
Unveiling the Hidden: A Search for Light Dark Matter with CCDs (DAMIC-M)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 3349563.0
EU funding (EUR): 3349563.0
Participants: 1
Project status: SIGNED

Dark matter (DM) is a ubiquitous yet invisible presence in our universe. It dictated how galaxies formed in the first place, and now moves stars around them at puzzling speeds. The DM mass in the universe is known to be five times that of ordinary matter; yet its true nature remains elusive. Weakly interacting massive particles (WIMPs), relics from the early universe, are a compelling explanation chased by sensitive experiments in deep underground laboratories. However, searches for heavy WIMPs (≈100 times the proton mass), the most theoretically natural candidates, have been so far unsuccessful. Nor has evidence for such heavy particles yet been found at the CERN Large Hadron Collider. Alternative scenarios are now under scrutiny, such as the existence of a hidden sector of lighter DM particles that interact, differently than WIMPs, also with electrons. DAMIC-M (Dark Matter In CCDs at Modane) will search beyond the heavy WIMP paradigm by detecting nuclear recoils and electrons induced by light DM in charge-coupled devices (CCDs). The 0.5 kg detector will be installed at the Laboratoire Souterrain de Modane, France. In this novel and unconventional use of CCDs, which are commonly employed for digital imaging in astronomical telescopes, the ionization charge will be detected in the most massive CCDs ever built with exquisite spatial resolution (15 μm x 15 μm pixel). The crucial innovation in these devices is the non-destructive, repetitive measurement of the pixel charge, which results in the high-resolution detection of a single electron and unprecedented sensitivity to light DM (≈ eV energies are enough to free an electron in silicon). By counting individual charges in a detector with extremely low leakage current – a combination unmatched by any other DM experiment – DAMIC-M will take a leap forward of several orders of magnitude in the exploration of the hidden sector, a jump that may be rewarded by serendipitous discovery.

Keywords: dark matter,hidden sector
Surface Acoustic Waves Stimulated Brillouin Scattering (SAW-SBS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Stimulated interactions between light and hypersonic elastic waves, known as stimulated Brillouin scattering (SBS), provide opportunities far beyond what is possible using light alone: From basic research of light-matter interactions and quantum mechanics, to ultra-narrow laser sources, spectroscopy, communication, signal processing and sensors. The realization of SBS in photonic integrated platforms provides large freedom of design, and would support mass production. The objectives of the proposed research program are to reveal, investigate and employ SBS processes on the most technologically-significant integration platform: silicon-on-insulator (SOI). Such interactions are largely considered out of reach. The silicon device layer of SOI does not guide acoustic modes, which leak away to the underlying bulk. Previous studies of SBS in silicon relied on suspended membranes and waveguides, in which the underlying silicon dioxide layer has been etched away. Suspended devices become fragile, and their subsequent processing is difficult. In addition, SBS in silicon has been restricted to the forward direction only. Forward scattering interactions are inherently difficult to localize. To overcome this challenge, I propose to rely on surface acoustic waves (SAWs) that are guided by the upper interface between the solid substrate and the air above. The propagation of SAWs is supported by SOI, however they were not yet considered towards SBS in this platform before. Backwards SBS will be realised between guided light in a standard SOI waveguide, with an underlying oxide layer, and a surface acoustic mode. Analysis shows that the effect should be strong enough to be observed, and also employed in signal processing and sensing applications. Additional objectives include SAW-photonic chips with tuneable acoustic frequency and SAW spectroscopy on-chip. The program outcomes could add another dimension to standard silicon-photonics, that of acoustics.

Keywords: silicon photonics,opto mechanics,brillouin scattering,optical signal processing,microwave photonics,photonic integrated circuits,acoustic spectroscopy
Evolving FIRE into a 5G-Oriented Experimental Playground for Vertical industries (5GINFIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Greece,France,France,United Kingdom,Brazil,Portugal
Call: Future Internet Experimentation - Building a European experimental Infrastructure (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 5382782.5
EU funding (EUR): 4999970.0
Participants: 11
Project status: CLOSED

Key industrial sectors e.g. automotive, are rapidly transformed by digital and communication technologies leading to the fourth industrial revolution. New ones are in the making, e.g. Smart Cities, which inspire a new breed of applications and services. The salient characteristic of these sectors, known as verticals, is that they are rapidly becoming open ecosystems built on top of common physical infrastructures and resources. This requires a high degree of technological convergence among vertical industries empowering them with enhanced technical capacity to trigger the development of new, innovative products, applications and services. 5G network infrastructures and embodied technologies are destined to “become a stakeholder driven, holistic environment for technical and business innovation integrating networking, computing and storage resources into one programmable and unified infrastructure”. It is this 5G vision that when it is further projected to accommodate verticals raises a number of technical issues Motivated by them, 5GinFIRE project aspires to address two interlinked questions: - Q1: How such a holistic and unified environment should look like? - Q2: How can 5GinFIRE host and integrate verticals and concurrently deal with reconciling their competing and opposing requirements? Addressing these key questions, 5GinFIRE main technical objective is to build and operate an Open, and Extensible 5G NFV-based Reference (Open5G-NFV) ecosystem of Experimental Facilities that integrates existing FIRE facilities with new vertical-specific ones and enables experimentation of vertical industries. In order to guarantee architectural and technological convergence the proposed environment will be built in alignment with on-going standardization and open source activities. Accordingly, the Open5G-NFV FIRE ecosystem may serve as the forerunner experimental playground wherein innovations may be proposed before they are ported to emerging “mainstream” 5G networks.

Keywords: 5g experimental facilities in fire,5g experimentation,fire and 5g for vertical application sectors