Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Strengthening links between technologies and society for european disaster resilience (LINKS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Germany,Belgium,Netherlands,Netherlands,Denmark,Luxembourg
Call: Human factors, and social, societal, and organisational aspects for disaster-resilient societies (H2020-SU-SEC-2019, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 5151777.5
EU funding (EUR): 5151777.5
Participants: 15
Project status: SIGNED

In recent years, social media and crowdsourcing (SMCS) have been integrated into crisis management for improved information gathering and collaboration across European communities. The effectiveness of SMCS on European disaster resilience, however, remains unclear owing to the diversity among disaster risk perception and vulnerability LINKS sets out to understand and assess the effects of social media and crowd-sourcing (SMCS) on European disaster resilience. LINKS will develop a framework which can be used to understand, measure and govern SMCS for disasters, taking into account the diversity among disaster risk perception and vulnerability (DRPV), disaster management processes (DMP) and applied disaster community technologies (DCT) across European communities. The LINKS Framework consists of scientific methods, practical tools, and guidelines addressing researchers, practitioners and policy makers. The Framework will be developed and evaluated through five practitioner-driven European cases, representing different disaster scenarios (earthquake, flood, industrial, terror, drought), cutting across disaster management phases and diverse socioeconomic and cultural settings in four countries (Italy, Germany, Denmark, Netherlands). Furthermore, LINKS sets out to create a community of stakeholders, the LINKS Community, which brings together first-responders, public authorities, civil society organizations, business communities, citizens and researchers across Europe dedicated to improving European disaster resilience through the use of SMCS. The execution and success of the project relies on multiple levels of stakeholder engagement and knowledge exchange within the LINKS Community, facilitated online through the LINKS Community Center and in person through the LINKS Community Workshops. Overall, LINKS will provide sustainable, advanced learning on SMCS in disasters, in order to strengthen links between technologies and society for improved European disaster resilience.

Keywords: social media,disaster technologies,crowdsourcing,diversity awareness,disaster governance,risk perception,european disaster resilience,community resilience,first responders,peer learning
The solution for flexible bike sharing initiatives without fixed stations (BITRIDE BIKE SHARING)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-02-01
End date: 2018-11-30
Duration (months): 22.0
Total project cost (EUR): 3452875.0
EU funding (EUR): 2417012.5
Participants: 1
Project status: CLOSED

We are ZEHUS and represent an European excellence in the field of human-electric transport vehicles. Where we want to get: BITRIDE BIKE SHARING is our pivotal long-term entrepreneurial initiative, expected to boost our business; we aim at developing a new generation of sustainable, hybrid-bike sharing programs, which are keystone for making available zero emission personal transport worldwide. Existing pain points: sharing services of conventional e-bikes are affected by highest installation costs, due to the need for fixed stations (racks, charging stations and kiosks), ranging from 70% to 80% of direct capital costs required to launch a new bike sharing project. Our solution to pain points: the basic idea is to apply in new bike sharing initiatives our award-winning BIKE+ All In One, the first worldwide powertrain for full hybrid bikes that never needs to be recharged from the grid. We gave to our creation a bridge to the cloud, through a seamless Smartphone interface (Bitride App) that uses Bluetooth connectivity. BIKE+ AIO is the factor enabling a revolutionary solution: we are the sole company offering technology and services to create a fleet of hybrid bikes not needing fixed stations. Bike collecting areas and electrified kiosks are no longer necessary: we have designed an advanced info-mobility service offering comprehensive information supports users, who avail of the Bitride App to localise and rent the nearest bikes equipped with ad hoc padlocks (Smart Lock) for bicycle pickup and drop-off. Thanks to the SME Instrument we will enable sustainable bike sharing initiatives cutting down direct capital investment by up to 78% in comparison with conventional e-bike sharing schemes. Turnover: we plan to reach €46,82M of cumulated turnover by 2022 Key partners: Milan and Rozzano municipalities in Italy and Arnhem municipality in the Netherlands have expressed their interest in performing a pilot project and becoming early-adopter of our solution.

Keywords: hybrid bike,flexible bike sharing
Smart Technologies for eneRgy Efficient Active cooling in advanced Microelectronic Systems (STREAMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,France,France,France
Call: Generic micro- and nano-electronic technologies (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-06-30
Duration (months): 42.0
Total project cost (EUR): 3369513.75
EU funding (EUR): 3369513.75
Participants: 8
Project status: CLOSED

The aim of STREAMS is to bring Europe into the new leading thermal management paradigm and maintain EU position at the forefront of ICT development. With a focused consortium gathering complementary experts, STREAMS will develop a generic active cooling thermal management solution (reaching TRL4), to keep nanoelectronic devices and systems performances at their best, while meeting IC future challenges. To successfully integrate Versatile microfluidic actuation, Anticipating thermal map and Thermal energy harvesting in a Si-based interposer, STREAMS will: - Lay-out advanced functionalities for the power efficient cooling control of application use-cases with critical heat load spatial distributions including hotspot areas (150 to 300 W/cm2) and background areas (20W/cm2) and temporal heat load variation in typical sub-second time scale - Develop self-adaptive and controlled micro-fluidic actuators to decrease by 25% both the pressure loss and the fluid flow rate, while controlling the temperature distribution within 15% below the acceptable limits of each component for spatial and temporal heat flux variation scenarios - Integrate IC compatible passive heat flux sensors (sensitivity up to S=100mV/K) at the interposer level to anticipate thermal map variation (time response~200ms, lateral spatial resolution=500µm) - Take advantage of existing thermal gradients to embed high performance nanostructured thermoelectric generator (harvested power up to 10mW) to power local functionalities (microfluidic valves, power management and read-out circuits, control ASIC) - Integrate the developed functionalities into a Si based interposer to demonstrate a smart, adaptable and embedded active cooling thermal management solution with reduced footprint (70% thickness reduction) and reduced consumption (-50%) - Assess reliability and performances of STREAMS thermal management solution in real future high performance applications in micro-servers (P=50W) and network use cases (P=200W)

Keywords: thermal management,active liquid cooling,thermoelectrics,microfluidic,si based interposer,thermal sensor,energy harvesting,microchannel,self adaptive fins,microvalves,variable flow rate pump
Towards a next generation of water systems and services for the circular economy. (NextGen)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Belgium,Switzerland,Greece,Switzerland,Romania,Romania,China,Sweden,Sweden,Korea, Republic of,Greece,Switzerland,Hungary,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Water in the context of the circular economy (H2020-CIRC-2017TwoStage, 2017)
Start date: 2018-07-01
End date: 2022-11-30
Duration (months): 53.0
Total project cost (EUR): 11344256.56
EU funding (EUR): 9965230.51
Participants: 36
Project status: CLOSED

The NextGen initiative will evaluate and champion innovative and transformational circular economy solutions and systems that challenge embedded thinking and practices around resource use in the water sector. We will produce new understandings to underpin the exploitation of techniques and technologies that enhance our ability to recover, refine, reuse, repurpose, capture value from, and extend the use-life of, an ever-increasing range of resources and products, thereby projecting the European water and allied sectors as global circular economy pioneers. NextGen will demonstrate innovative technological, business and governance solutions for water in the circular economy in ten high-profile, large-scale, demonstration cases across Europe, and we will develop the necessary approaches, tools and partnerships, to transfer and upscale. The circular economy transition to be driven by NextGen encompasses a wide range of water-embedded resources: water itself (reuse at multiple scales supported by nature-based storage, optimal management strategies, advanced treatment technologies, engineered ecosystems and compact/mobile/scalable systems); energy (combined water-energy management, treatment plants as energy factories, water-enabled heat transfer, storage and recovery for allied industries and commercial sectors) and materials (nutrient mining and reuse, manufacturing new products from waste streams, regenerating and repurposing membranes to reduce water reuse costs, and producing activated carbon from sludge to minimise costs of micro-pollutant removal). The project mobilises a strong partnership of water companies, industry, specialised SMEs, applied research institutes, technology platforms, city and regional authorities and builds on an impressive portfolio of past research and innovation projects, leveraging multiple European and global networks guaranteeing real impact.

Keywords: circular water systems,water reuse,energy recovery,materials recycling,large scale demonstration,business models,knowledge co creation,marketplace,evidence base
Deep screening of proteins with a next generation sequencing platform (FUNC NGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Next generation sequencing (NGS) has become an indispensable tool for system biology and has recently been adopted in protein engineering science as well. This proposal describes the development of a highly generalizable technique, termed FUNC-NGS, which links in situ functional information of protein activity with the function-determining DNA sequence in a massively parallel manner opening exciting possibilities, e.g., in drug discovery. In this method a cell-free display platform is combined with NGS by modifying protein display units to contain unique homing oligonucleotide sequences. These units are subsequently targeted to bind monoclonal DNA clusters in the flow cell of an Illumina sequencer by complementary DNA hybridization. FUNC-NGS is readily compatible with a paired-end sequencing programme on the Illumina platform and the number of screening units is only limited by the number of DNA clusters on the flow cell. As the first application challenge, a new variant of a modified bacterial adhesin, Spycatcher, will be created with an altered specificity for synthetic biology applications. Novel Spycatcher-SpyTag pairs are intensively desired but their creation is demanding. Solving this problem will be a perfect showcase for this radically novel deep screening technology. At the mature stage FUNC-NGS will be a transformative platform in therapeutic protein development, functional genomics and personalized medicine. The proposed work will be carried out at Dr. Hollfelder´s laboratory at the University of Cambridge with a short secondment at Medimmune. Hollfelder group has developed SNAP display, which is a FUNC-NGS-compatible in vitro protein display system. Furthermore, the University hosts excellent facilities for NGS sequencing and experienced bioinformatics support is available. The planned research programme synergistically combines my expertise in molecular biology method development with the hosts expertise in cell-free display and IVC-techniques.

Keywords: next generation sequencing,protein screening,high throughput,combinatorial libraries,protein engineering
Cooperative, Greener, Multivendor Cognitive Software to Maximize the Performance of Next-Generation Wireless Networks (ECOWIFI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-02-28
Duration (months): 30.0
Total project cost (EUR): 1909028.75
EU funding (EUR): 1336320.13
Participants: 1
Project status: CLOSED

In a wireless world, where users and things demand a growing hyper-connectivity, offering a quality WiFi service for final users is almost impossible. This is due to the fact that the current trends promote a captive market and vendor lock-in. Nobody is facing effectively the problem of high-density, high-interfering, next-generation WiFi networks. Galgus has come to solve this problem, by disaggregating WiFi optimization and management software from hardware, pursuing a collaboration paradigm for APs (Access Points). The technology proposed in ECOWIFI solves the pains of the main players in this sector: Network Owners (easy and affordable operation, maintenance, updating, and analytics), System Integrators (vendor-independence and optimization), and Hardware Manufacturers (cost of developing their own research lines). We have created Cognitive HotspotTM Technology (CHT), a patented, multiplatform, and distributed embedded software for WiFi devices, in order to optimize resources and to bring intelligence to the network. We have shown 12x performance improvement with the same hardware (up to 98% cost reduction), and 2x performance with less hardware (up to 80% cost reduction). CHT pursues a cooperation paradigm for WiFi. Galgus plans to scale up globally by consolidating CHT as best-class technology for WiFi optimization in the niche markets of connected transport and industry, where there is few competition. The SMEi2 will allow Galgus to position Galgus as Industry Leader in front of the main stakeholders in the value chain. This will allow the company to accelerate its market entry and achieve sales of approx. 30.9 M€ in 2023, with an accumulated net margin of 23.5 M€.

Keywords: wifi,spectrum optimisation,saas,connected transport,distributed intelligence,hardware independence,access points
Integration Mapping of refugee and Migrant Children in Schools and Other Experiential Environments in Europe (IMMERSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Ireland,Spain,Spain,Spain,Belgium,Greece,Greece
Call: Mapping and overcoming integration challenges for migrant children (H2020-SC6-MIGRATION-2018, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 2990343.75
EU funding (EUR): 2990343.0
Participants: 11
Project status: SIGNED

The IMMERSE project “Integration Mapping of refugee and Migrant Children in Schools and Other Experiential Environments in Europe” emerges at a time where Europe and its socio-educational system are facing a lot of pressure because the migration flows and the current refugee crisis. In this situation, refugee and migration children are the most vulnerable group and Europe is committed to provide them support and to promote more inclusive European societies. In this sense, IMMERSE aims to enhance the socio-educative inclusion of all refugee and migrant children through the generation of new data and policy recommendations on the integration of refugee and migrant children. An innovative and ICT supported solution has been proposed to carry out research activities in order to create a dashboard of socio-educational indicators that will allow to collect information to be analyzed and become practical policy recommendations. IMMERSE aims to foster the empowerment of children and other relevant stakeholders that impact on their integration and successful transition to adulthood into host societies. IMMERSE follows a whole school approach and aims to implement co-creation methods to involve all the key actors in the achievement of the results.

Keywords: social psychology,social indicators,educational indicators,integration,cocreation,wellbeing,intercultural competences,research,social research
Endothelial Cell Molecular and Metabolic Heterogeneity in Pulmonary Arterial Hypertension (EMPAtHy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

BACKGROUND: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by a dramatic increase in pulmonary arterial pressure and an intense remodeling of small intrapulmonary arteries. With the exception of the lung replacement therapy, PAH remains an incurable disease with poor survival. Recent studies have shown that in PAH, rewiring of the metabolism of the lung endothelial cells (ECs) promotes vascular remodeling. However, these studies overlooked that lung ECs are exposed to diverse microenvironments in vivo (various hemodynamic forces and stimuli), which might result in their phenotypic and metabolic heterogeneity, though this has never been investigated. OBJECTIVES & EXPERIMENTAL APPROACH: In order to characterize, for the 1st time, the lung EC heterogeneity in PAH, identify EC subsets, and determine in an unbiased way the metabolic gene expression profiles of these EC subsets, I will use single-cell RNA-sequencing (scRNA-seq) on freshly isolated lung ECs from PAH patients and from an animal model of PH. As proof-of-concept, I will evaluate the effects of a new metabolic therapy on these EC subsets, in vivo, in comparison to a clinically-used, ameliorative but not curative, PAH therapy. This approach, already validated in the host lab, promises to lay the foundation of a new paradigm in PAH where lung ECs are phenotypically and metabolically heterogeneous. It will yield novel insights into PAH pathophysiology, identify specific EC subpopulations driving the vascular remodeling process as well as new potential metabolic targets. CAREER DEVELOPMENT: Combining my expertise on PAH (PhD thesis) together with state-of-the-art frontline technology (scRNA-seq) and innovative science (EC metabolism) (within the host lab) in a multi-disciplinary project and international research environment will ensure successful achievement of the project goals, enhance my scientific output and offer me a highly competitive basis for my future career in academia.

Keywords: pulmonary hypertension,metabolism,endothelial cell,single cell rna sequencing,vascular remodelling
Instructing Immune System to Regenerate Musculoskeletal Tissues via Structurally Programmable Bio-Inks (ImmunoBioInks)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

The musculoskeletal tissue is the framework of our lives. It holds, shapes and supports freedom of movement of our body and protects the crucial internal organs (brain, heart and lungs). It is responsible for our body’s immunity by providing source of stem cells (bone marrow) that readily transform to immune system cells fighting pathogens, so any damage it poses significant threat to the individual’s quality of life. The patient’s immune system does not only play crucial role in fighting various pathogens but is also vital in inducing normal healing of damaged tissues. Patients, especially with prolonged diseases, ranging from diabetes to HIV tend to have decreasing capacity for healing after injuries due to their compromised immune system. In this project we aim to develop 3D-printed materials instructing the immune systems via the immune cell-material interactions through controlled mechanical properties and biochemical cues organised in 3D manner (i.e. biofabrication using additive manufacturing techniques) for treatment of musculoskeletal defects in patients with immune-system imbalance. Chemical approaches combining synthetic self-assembling peptides and hyaluronic acid together with 2D nanomaterials will be explored for fabrication of such well-defined printable scaffolds with high shape fidelity and gradient-like architecture. In a second step, we hypothesise that reprogramming of patient’s own immune cells (ex-vivo) using the developed printed materials and a microfluidic approach can be achieved through the stimulation of patient’s immune cells interacting with the designed material surfaces to produce the exosomes and signalling molecules (cytokines). Successfully harvested biomolecules would hold potential for personalized therapies in immune-deficient patients and could be re-applied using standard practises and injectable bio-fillers.

Keywords: 3d printing,biofabrication,nanocomposites,2d materials