Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploiting Flexible pErovskites Solar technOlogies (EFESO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States,Poland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-26
End date: 2026-06-25
Duration (months): 36.0
Total project cost (EUR): 288112.44
EU funding (EUR): 288112.44
Participants: 3
Project status: SIGNED

EFESO, acronym of "Exploiting Flexible pErovskites Solar technOlogies" aims to bring perovskite technology on flexible substrates towards commercialization. This project aims at upscaling stable Flexible Perovskite Solar Modules (FPSMs) by optimizing their fabrication process on flexible substrates, reducing inactive areas on modules, and by working on lead (Pb) trapping intrinsically, using doping and interface engineering, and extrinsically by encapsulation strategies. The proposed project is divided into 3 main parts: 1. Materials: assessment of the flexible substrates, additives, and interface layers to get the best and stable layer to be used for device fabrication; 2. Device: fabrication and characterization of devices, focusing on lead trapping strategies by encapsulation and interface engineering; 3. Upscaling: optimization of the design and laser processes of P1-P2-P3 for indoor and outdoor applications (standard procedures to create a series connection of cells, to reduce losses encountered for large-area devices). The principal objective of this action will be the fabrication of Flexible Perovskite Solar Cells with performances of 23% and 35% on small area devices at 1 Sun and 1000lx intensity respectively, FPSMs with power conversion efficiency (PCE) of 21% and 18% on an area greater than 10cm2 and 200cm2 respectively. All devices fabricated will pass the ISOS D-L-T-1 tests and they will show a reduction of lead leakage by 4-5 orders of magnitude A final product demonstrator will be fabricated showing the applicability of these devices into the market. The action will bring new materials, additives, sealants, polymers, solvent concentrations used to limit lead leakage, and build a stable and highly efficient device on a flexible substrate, from cell to module size. For these reasons, this action will grab the attention of the scientific community that will recognize this work as a potential path for prompt commercialization.

Keywords: perovskites,flexible substrates,perovskite solar technologies,solar technologies,perovskite solar modules,commercialization,iot,semiconductors,interface engineering,solution processes
SHARE: a remote tool for automated speech and language language assessment of children and personalised interventions. (SHARE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Ireland
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2022-11-30
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Speech and language development is one of the most critical developmental phases in early childhood. Children with poor vocabulary skills at age 5 were four times more likely to have reading difficulties, three times as likely to have mental health problems, and twice as likely to be unemployed when they reached adulthood. Yet it’s one of the most overlooked industries in terms of innovation, the way speech and language development is managed by parents, teachers and healthcare providers has not changed in DECADES. There is an over-reliance on the clinical speech and language therapists as the only means to get an assessment of a child’s speech and language skills. The result of this is children sitting on waiting lists or having early signs of delays missed, all resulting in missing out on reaching critical speech and language developmental milestones. We are developing SHARE, a radical, data driven and digitally-delivered solution to address the problems in understanding children’s speech and language development. Delivering accurate, in-home assessment of speech skills is the key to disrupting this industry, empowering the other stakeholders in this story to understand when a child’s speech skills are on track and when they are not. Our goal is to reduce the over reliance on costly face to face therapy by developing solutions that don’t just replicate existing practice but are developed around data and evidence and reflect the abilities and lifestyles of families. This is a relatively new market segment that crosses several markets and stakeholders across Speech therapy, Digital Health and the emerging New Mom Economy. We will use Women TechEU support to liaise with these stakeholders, develop commercial relations with them and build a regulatory compliance strategy for SHARE. All of these will be leveraged to get contact with and secure the investment needed to complete SHARE development and bring it to the market.

Keywords: digital health,early childhood development,voice technology
LysoIP based-lysosomal signatures in Parkinson's Disease (LEGEND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 2
Project status: SIGNED

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting 10 million people worldwide. No curative treatments are currently available, but only symptomatic ones. Emerging evidence highlights lysosomal dysfunction as a key mechanism in PD pathogenesis, with associated mutations in the LRRK2 and SNCA genes, both linked to lysosomal pathways. This proposal aims to identify common lysosomal biomarkers associated with PD progression. By employing the innovative LysoIP method, which enables precise lysosome isolation, we will analyse lysosomal profiles in two PD mouse models of LRRK2 and alpha-synuclein across different ages. Our objectives include (1) setting up and validating the LysoIP method in wild-type mice, (2) identifying potential lysobiomarkers in PD mouse models, and (3) validating these biomarkers in cellular models of PD. This project directly aligns with the EU Work Programme under Horizon Europe, which focuses on advancing our understanding of neurodegenerative diseases and accelerating the discovery of disease-modifying therapies. Identifying lysosomal biomarkers will not only improve our understanding of PD mechanisms but also support the development of novel therapeutic approaches targeting lysosomal dysfunction.

Keywords: parkinson s disease,lysosomes purification,protein trafficking,mouse brain,human ipscs
Poly(ionic liquid)s assist diatomic catalysts in achieving highly efficient CO2 conversion in Li-CO2 batteries (PASSION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-16
End date: 2027-01-15
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

The rising CO2 emission has underscored the need for innovative approaches toward CO2 management. Li-CO2 batteries provide a promising strategy for direct CO2 fixation in energy storage devices with a high theoretical specific energy of 1876 Wh/kg, highlighting in effective CO2 management. A key challenge in Li-CO2 batteries is that the sluggish CO2 conversion including CO2 reduction reaction (CRR) and evolution reaction (CER) in cathode seriously deteriorates battery performance. In this project, we propose an integrated cathode design with combined pre-activator molecules and bidirectional atomic catalytic materials in cathode for improving CO2 conversion efficiency. Poly(ionic liquid)s (PILs) with high CO2 affinity, good compatibility to lithium salt and wide electrochemical window, are designed with amine groups as pre-activators in cathode for achieving CO2 activation before electroreduction on catalysts. The diatomic catalysts (DACs) with highly active dual metal centres and theoretical 100% atom utilization, are screened out as bidirectional catalysts for improving CRR/CER simultaneously. Such PILs-modified DACs will be 3D printed into self-supporting integrated cathode with designed open channels and interconnected conductive skeleton, to grant enough solid products support and effective transportation of CO2, Li ion and electron in cathode. Consequently, Li-CO2 batteries with long cycle life (over 1000 cycles) and high energy density (500 Wh/kg or above) will be targeted. In combination with in situ electrochemical characterizations and DFT calculations, mechanism of CO2 conversion in designed cathode will be clarified in this project. Results from this project will inspire cathode design of Li-CO2 batteries on pre-activator and catalytic conversion beyond direct electroreduction on catalysts. It will broaden the perspective on atomically dispersed catalysts and promote the development of energy storage devices accompanied by CO2 utilization.

Keywords: poly ionic liquid s,diatomic catalysts,co2 conversion,batteries
Novel metal-organic framework adsorbents for efficient storage of hydrogen (MOST-H2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Germany,United Kingdom,France,Spain,Morocco,Austria
Call: Advanced materials for hydrogen storage (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 4917262.5
EU funding (EUR): 4917262.5
Participants: 16
Project status: SIGNED

Widespread use of hydrogen as an energy carrier is a key priority for the EU, in order to achieve its climate and energy transition targets. Developing sustainable, efficient and safe hydrogen storage technologies has, however, proved challenging. MOST-H2, in full alignment with the requirements of HORIZON-CL4-2021-RESILIENCE-01-17, proposes an integrated multiscale lab-to-tank approach to develop, validate and demonstrate innovative, low cost cryo-adsorptive hydrogen storage, using monolithic Metal-Organic Framework (MOF) adsorbents, with an optimal combination of volumetric and gravimetric capacity, but also a small environmental footprint. Advanced synthetic strategies and sophisticated computational techniques, including molecular simulation and machine learning, will be combined in a cyclic materials development approach, to deliver new high performance, sustainable-by-design MOF adsorbents. The main aim is to computationally design, then synthesise and validate experimentally, ultra porous MOFs with usable storage capacities above 10 wt% and 50 g/L on a materials basis, at an operating pressure below 100 bar. This represents an essential step towards more efficient, intrinsically safer and cost effective storage solutions, compared to conventional hydrogen storage technologies. An important part of the project will be devoted to developing and upscaling monolithic forms of optimal MOF materials to allow easy integration into a cryo-adsorption storage tank, specifically designed for this purpose, which will be tested in a TRL 5 environment. The outcomes, coupled with full life cycle analysis and techno-economic assessment of MOST-H2 technology, with a view to selected end uses (rail and road applications), will form the basis for elaborating future market penetration plans through a solid horizontal dissemination and exploitation strategy.

Keywords: metal organic frameworks porous materials hydrogen storage adsorption computational chemistry machine learning
UNified archITecture for Open RAN-enabled Distributed, Scalable and SustainabilitY-enhanced 6G Networks (UNITY-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Spain,Denmark,France,Germany,Ireland,Greece,Romania,Italy,Belgium,Switzerland,Poland
Call: System Architecture - Standardisation and Follow-up/PoCs (HORIZON-JU-SNS-2024, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 8515314.83
EU funding (EUR): 7978392.01
Participants: 21
Project status: SIGNED

UNITY-6G aims to create a highly sustainable and scalable integrated AI-native architecture that can support the diverse requirements of 6G networks by relying on advanced technologies, such as distributed ledger technology, semantic communications, digital network twinning to enhance the performance, cost-efficiency and trustworthiness of integrated 6G network services and applications. The focus is on scalability and sustainability for integrated networks (Non-Terrestrial and Terrestrial Networks, xHaul, Open RAN, Non-Public Networks, Edge, Core and Cloud). Furthermore, UNITY-6G aims to evolve to real-time distributed and network state-aware Open RAN that can leverage the integration of distributed applications in the integrated architecture. This will enable fine-grained data-driven management and control via incorporating dApps, distributed applications that complement existing xApps/rApps and use cases with stricter timing requirements in an integrated network. Common interfaces and protocols will be defined so that different heterogenous domains can communicate seamlessly. To better guide the design, UNITY-6G will use the principles of service-based architecture for integrated networks and leverage digital twins for network evaluation. UNITY-6G considers four use cases targeting: i) Sustainable networks for disaster handling, (ii) Immersive Experience with Real-time XR/holographic communications, (iii) Digital Twin for Integrated 6G Network Evaluation, (iv) Multi-RAT O-RAN enabled NPN for supporting time sensitive applications for Industry 4.0.

Keywords: distributed ai,network management,time sensitive networks,integrated 6g architecture,sustainable networks
International Training for Doctoral Research on Advanced Gene and Cell Therapies (RAREFIND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2613600.0
EU funding (EUR): 2613600.0
Participants: 1
Project status: SIGNED

The RAREFIND project is an innovative doctoral training program designed to meet the growing need for specialized education in advanced gene and cell therapies. Coordinated by Fondazione Telethon (FTELE) with the School of Advanced Studies (IUSS) as implementing partner, RAREFIND offers a dynamic interdisciplinary and intersectoral training environment. The program encourages international mobility and promotes excellence in research across FTELE’s leading institutes, TIGEM and SR-TIGET, both recognized for their pioneering contributions to genetic research and therapy development. RAREFIND aims to train 22 doctoral candidates (DCs) through cutting-edge research projects on gene therapy, gene editing, and related fields. Participants, selected through a rigorous and competitive process, will receive comprehensive education combining scientific expertise with transferable skills. They will gain hands-on experience in leading laboratories, collaborate closely with non-academic entities, and benefit from secondments and specialized training. This approach ensures exposure to a broad range of perspectives, preparing DCs to advance the development of personalized therapies for rare genetic diseases. A key pillar of the program is its emphasis on career development. RAREFIND offers tailored mentorship, targeted professional skills training, and opportunities to engage with leaders from academia, industry, and regulatory bodies. This holistic approach ensures that graduates are equipped not only for academic research careers but also for leadership roles in biotechnology, pharmaceutical companies, and other sectors in gene and cell therapies. By integrating translational research with real-world applications, RAREFIND accelerates the transformation of scientific discoveries into therapeutic solutions, strengthening Europe’s biomedical landscape.

Keywords: gene therapy training cell therapy doctoral network
An AI-Powered Visual Assistive Design IoT Pathway Platform to implement fast and optimal automated patient pathways and healthcare demand planning projects (PATHMAKER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Spain
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 2586500.0
EU funding (EUR): 1810550.0
Participants: 1
Project status: CLOSED

MYSPHERA has rolled out a game changing IoT location solution to track and manage patient pathways in real time. It automates the surgical process by means of tailored applications that empower staff with live patient-flow data and notifications. As a result, the solution has obtained references in several EU countries that note a significant capacity increase. Deploying this solution takes few months of co-design work with the hospital, which limits its scale-up potential. We aim to reduce the effort and time by an order of magnitude, falling from months to just a few days. An AI-Powered Visual Assistive Design IoT Pathway Platform based on Spatial Process Mining and Machine Learning technologies has been prototyped to complete this radical leap by streamlining the design, tailoring and deployment of optimal pathways and elective care planning projects, for any hospital, unit, and in a matter of days.

Keywords: efficient clinical pathways,hospital productivity,cutting waiting lists,improving staff,patient and family experience,cutting installation times dramatically
Dissecting long non-coding RNA function using in vivo synthetic biology (SynLncRNAs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Precise spatiotemporal regulation of gene expression is essential for healthy embryonic development. Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression. However, our current understanding of lncRNAs derives mostly from in vitro studies, with little known about their function in vivo. The core aim of this action is to dissect mechanisms of gene regulation by lncRNAs in vivo. The lncRNA Maenli is a perfect model to gain insight into lncRNA function as it activates a specific target gene in a tissue-specific manner during mouse embryonic development. This enables a quantitative in vivo read-out without compounding genome-wide effects. My hypothesis is that Maenli function is restricted to its 3D chromatin domain where it activates its target gene through transcription-associated processes, and not via the mature lncRNA transcript. To test this, I require methods that enable manipulation of the entire ~25kb locus and site-specific insertion in the genome. I will use cutting-edge synthetic biology to re-construct and manipulate Maenli, insert it in specific genomic regions, and examine its effect on target gene expression and phenotype in the mouse embryo. I will use low-input CUT&RUN to assess the functional chromatin state associated with Maenli. This interdisciplinary approach will go beyond the state of the art to illuminate specific mechanisms of cis-acting lncRNA function in vivo. This has not been possible until now due to technical limitations in conventional gene editing and challenges associated with studying lncRNAs in vivo. I anticipate that SynLncRNAs will set a new standard to study lncRNA function in vivo; impacting fundamental, disease and evolutionary research on gene regulation, as well as society and education. With expertise in the non-coding genome and in vivo synthetic biology, the Mundlos laboratory is the perfect environment for me to execute this action and train to become an independent group leader in the future.

Keywords: long non coding rnas,lncrnas,epigenetics,gene regulation,developmental biology,synthetic biology,genomics