Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protection of cardiometabolic inflammation by modulation of myeloid glutamine homeostasis (PROGLUTASIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2023-09-30
Duration (months): 78.0
Total project cost (EUR): 2091338.0
EU funding (EUR): 2091338.0
Participants: 1
Project status: SIGNED

The metabolic syndrome (MetS) represents one of the major public health challenges worldwide. It reflects a combination of medical disorders that, when occurring together, increase the risk of developing diabetes and cardiovascular disease. The prevalence in the USA is estimated at 30% of the population and the European community follows this trajectory. It is now recognized that the state of chronic low-grade inflammation may favor the onset and progression of the MetS. While the notion of metabolic flexibility in hematopoietic cells has recently emerged in several inflammatory diseases, the origin of this immunometabolic alteration in the MetS remains elusive. There is a growing appreciation that the apportioning of nutrients into different metabolic pathways can support or direct functional immune and hematopoietic changes. Glutamine is the most abundant amino acid in the plasma and an important energy source through glutaminolysis. Despite its potential proliferative and/or immunosuppressive function and the strong association between high glutamine-to-glutamate ratio with cardiometabolic traits, the underlying mechanisms are poorly understood. Thus, there is a considerable therapeutic interest in better understanding the mechanisms linking glutamine to cardiometabolic risks and in particular cardiometabolic inflammation. In PROGLUTASIS, we will investigate the metabolic and immune regulation of glutamine homeostasis in the metabolic syndrome. We will validate the contribution of glutaminolysis in cardiometabolic inflammation, including obesity, diabetes and atherosclerosis through its role on hematopoiesis and macrophage dynamics. Given the ubiquitous association between glutamine and chronic metabolic stress, we expect that identifying the underlying molecular mechanism will offer novel therapeutic perspective on how to intervene in this pathway. This will ultimately allow for tailored strategies aimed at dampening cardiometabolic inflammation in the MetS.

Keywords: cardiometabolic diseases,glutamine,glutaminolysis,immunometabolism,low grade inflammation,macrophages,efferocytosis,hematopoiesis,hematopoietic stem cells,proliferation,redox,obesity
Innovation capacity building in Ukrainian SMEs and enhancing cooperation with European SMEs (EEN-Ukraine)

Framework: Horizon 2020 — EC Treaty
Action type: Specific Grant agreement
Countries involved: Ukraine
Call: EEN H2020 SGA2 2D BATCH (H2020-EEN-SGA2-2017-1, 2017)
Start date: 2017-05-01
End date: 2018-12-31
Duration (months): 20.0
Total project cost (EUR): 75750.0
EU funding (EUR): 75750.0
Participants: 8
Project status: CLOSED

The overall / general objective of this proposal is to increase innovation potential and innovation management skills within SMEs in the all regions of Ukraine and to assist SMEs with potential for international growth via product, process, service or business model support. The project will follow a defined methodology to help regional businesses to increase their innovation capacity, to innovate profitably and also to successfully implement their innovative ideas on the competitive market. The EEN-Ukraine Consortium intends to enhance innovation capacity of SMEs by encouragement their participation in Horizon 2020 projects and provision of key account manager services to SMEs which implement H2020 SME Instrument projects. The secondary target group will be R&D organisations that will benefit from EEN services as well. The specific objectives for reaching the overall / general objective are as follows: - promote and support SMEs from Ukraine in participation on the H2020 SME Instrument and other H2020 programmes; - identify weaknesses in the innovation capacities of the beneficiary that hinder the realization of growth opportunities and of the full commercial potential of SME Instrument participants; - identify suitable coaches to address the identified weaknesses and moderating the coach-client relationship; - increase the innovation potential of SMEs lacking professional support in the field of innovation management; - help SMEs to select the most appropriate coach; - explain and sell the benefits of the SME Instrument's coaching service to potential beneficiaries; - facilitate the SME- coach relationship and ensure the effective teamwork and co-operation between the SME; - secure close cooperation links between the Consortium and the H2020 National Contact Point, regional stakeholders and other business and research support institutions; - accompany the beneficiary through the SME instrument project; - make the innovation system of Ukrainian SME more effective.

Keywords: industry,smes,academia,technology transfer,innovations,kam scheme
Representational Mechanisms of Neural Location Encoding of Real-life Sounds in Normal and Hearing Impaired Listeners. (SOLOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 182419.2
EU funding (EUR): 182419.2
Participants: 2
Project status: CLOSED

With the rise of urbanization, silence has become a rarity. Sound is all around us, and our hearing skills are essential in everyday life. Spatial hearing is one of these skills: We use sound localization to determine where something is happening in our surroundings, or to ‘zoom in’ on a friend’s voice and filter out the noise background in the bar. But how does the brain compute the location of real-life, complex sounds such as a voice? Knowledge of these neural computational mechanisms is crucial to develop remedies for when spatial hearing fails, such as in hearing loss (>34 million EU citizens). Hearing impaired (HI) listeners experience great difficulties with understanding speech in everyday, noisy environments despite the use of an assistive hearing device like a cochlear implant (CI). Their difficulties are partially caused by reduced spatial hearing, which hampers filtering out a specific sound such as a voice based on its position. The resulting communication problems impact personal wellbeing as well as the economy (e.g. higher unemployment rates). In SOLOC, I use an innovative, intersectional approach combining cutting-edge computational modelling (deep neural networks) with state-of-the-art neuroscience and clinical audiology to gain insight into the brain mechanisms underpinning sound localization. Using this knowledge, I explore signal processing strategies for CIs that boost spatial encoding in the brain to improve speech-in-noise understanding. Through this Global Fellowship, I connect the unique computational expertise of Prof. Mesgarani (Columbia University) and his experience with translating computational neuroscience into clinical applications, to the exceptional medical expertise on hearing loss and CIs of Prof. Kremer (Maastricht University). Hence, by implementing SOLOC I will diversify myself into a multidisciplinary, independent researcher operating at the interface of neuroscience, computational modelling, and clinical audiology.

Keywords: sound localization,hearing loss,fmri,ecog
Twinning foR indUstrial SustainabiliTy (TRUST)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Sweden,United Kingdom,Portugal
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-10-01
End date: 2022-06-30
Duration (months): 45.0
Total project cost (EUR): 996390.0
EU funding (EUR): 996390.0
Participants: 3
Project status: CLOSED

The TRUST project aims to boost research excellence in the area of INDUSTRIAL SUSTAINABILITY by increasing the scientific and technical capacities. This will allow to support and engage European industries in their pathway to the achievement of the Sustainable Development Goals. TRUST partnership brings together ISQ, a Portuguese research institution and two internationally-leading universities - University of Cambridge and Chalmers University. In TRUST, ISQ will be building upon their experience and development potential it has demonstrated in this area to address their issues related to the lack of both scientific culture to systematize/theorize of their project results (leading to poor scientific productivity) as well as lack of specialized training in emerging sustainability assessment and management tools. The TRUST concept will be achieved following an approach based on an active shared learning strategy, based on: 1) Training of staff on-campus, on-line courses and webinars; 2) joint initiatives including staff exchange, joint supervision, experience of different research & organizational cultures, scientific review, organization of biannual summer schools and joint scientific publications and 3) dissemination and communication strategy allowing the engagement of relevant stakeholders, namely by TRUST workshops and annual stakeholder exchange forums, to foster the identification of new partnerships and industrial driven research opportunities. The TRUST partnership will not only improve the scientific and technical capacities of ISQ but will also set the basis for a long lasting cooperation for the development of excellence research in service of the European industry. This initiative will create a Joint Research Agenda beyond TRUST project lifetime, aiming to contribute to a more balanced development of the European Research. This twining initiatives are aligned with the European Commission strategy for the creation of “stairways to excellence”.

Keywords: industrial sustainability,resource efficiency,industry driven research,active shared learning,collaborative research
Model-based biomarkers for the characterization and quantification of global states of consciousness (MBMsforDOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Studying the brain mechanisms behind consciousness is a major challenge for neuroscience and medicine. Yet so far, there is no such thing as a unique biomarker that can precisely define the state of consciousness of a disorders of consciousness (DOC) patient. All the biomarkers proposed so far are theory-based but empirically defined (EBM; empirical biomarkers): the thresholds that separate categories are set in a data-driven way. In this project, we propose a novel approach using model-based biomarkers (MBM). This new family of biomarkers (MBMs) will not only complement the EBMs but mainly will naturally address the knowledge gaps associated with the understanding of the underlying causal mechanisms behind the different states of consciousness. The modelling of the structural and functional connectivity will be combined with novel, systematic perturbational approaches that can provide new insights into the human brain’s ability to integrate and segregate information over time. In particular, with this approach we will address the hypothesis that MBMs provide functional fingerprinting of conscious states and insights into the underlying necessary and sufficient brain networks as well as their neural mechanisms. To address the development of these biomarkers, we propose a highly interdisciplinary project that combines basic and clinical neuroscience with whole-brain computational modelling proposing a synergy between two groups with large expertise in each area to address a common question We will develop computational whole-brain models based on single-patient neuroimaging data. We will extract MBM from the adjusted model parameters and from in-silico simulations. We will test the utility of these biomarkers for the diagnosis of patients with chronic DOC. Then, we will contrast the MBM with a set of previously developed EBM. Finally, we will analyze the diagnostic and prognostic capacity of these biomarkers in DOC patients in both chronic and acute stages.

Keywords: disorders of consciousness,consciousness,biomarkers,computational modelling,fmri,vegetative state,minimally conscious state
Multi-actor design of low-waste food value chains through the demonstration of innovative solutions to reduce food loss and waste (LOWINFOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Italy,Austria,Germany,Italy,Germany,Italy,Germany,Germany,Spain,Finland,Greece,Sweden,Switzerland,Belgium,Bulgaria,Greece,Greece,France,United Kingdom
Call: Reducing food losses and waste along the agri-food value chain (H2020-RUR-2020-1, 2020)
Start date: 2020-11-01
End date: 2025-02-28
Duration (months): 52.0
Total project cost (EUR): 5979816.09
EU funding (EUR): 5534161.8
Participants: 27
Project status: SIGNED

LOWINFOOD supports the reduction of food loss and waste in European Union by demonstrating innovative solutions following a multi-actor approach that involves actors along the entire value chains. The main objective of the project is to co-design, together with actors of the food chain, low-waste value chains by supporting the demonstration of a portfolio of innovations in the fruits & vegetables, bakery products and fish value chains, as well as in a-home and out-of-home consumption. Proposed solutions are already tested as prototype in lab or in relevant environment but are waiting to be validated and demonstrated to TRL 7/8. The impact of the innovations will be evaluated by providing evidence of (i) their efficacy in reducing food loss and waste in different food value chains, (ii) improving the socio-economic performance of these value chains, and (iii) reducing the environmental impact of the value chains concerned. LOWINFOOD comprises seven interrelated work packages, among which four deal with the demonstration and market replication of the innovations addressed by the project (WP2-5), one to be started before the demonstration of innovations, and seeking to implement a multi-actor approach to support the evaluation of the innovations and including the identification of the methodology, the definition of the Key Performance Indicators (KPIs) and the actual evaluation (WP1), one to communication, dissemination and market replication (WP6) and one for project coordination management (WP7). The LOWINFOOD consortium includes universities, research institutes, start-ups, foundations, associations and companies working in the food sector with expertise in all relevant scientific and technical areas covered by the project: innovation, demonstration, knowledge transfer, dissemination, policy advice and marketing strategy.

Keywords: multi actor process,food value chain,innovation demonstration,stakeholder engagement
Interrogating the diversity of gut colonization strategies in multidrug-resistant E. coli to deduce robust competitive exclusion-based treatments (ECOSTRAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1993191.0
EU funding (EUR): 1993191.0
Participants: 1
Project status: SIGNED

The rise of multidrug-resistant bacteria limits the options to treat critically ill patients. In 2015, Escherichia coli producing Extended Spectrum β-Lactamases (ESBL) were the leading cause of death attributable to antibiotic resistant bacteria in Europe. The failure to address these infections using standard antibiotherapy calls for better understanding of how these bacteria evolve in order to develop new treatments. Presence of resistance and virulence genes correlates with high prevalence in ESBL clones. Since the intestinal tract of mammals represents a major ecological niche for E. coli, gut colonization ability must have predisposed certain clones to evolutionary success during the antibiotic era. In particular, competition against the gut microbiota should select for colonization factors that predate the acquisition of resistance. To test this hypothesis, we will compare strategies for gut colonization in ESBL clones of different prevalence in absence of antibiotics. Using mice, we will be able to modulate selective pressures exerted by the intestinal microbiota. We will compare gut colonization factors in ESBL clones by performing parallel high-throughput genetic screening in conventional mice (aim 1). We will analyze adaptability and the stability of resistance and virulence genes during long-term colonization (aim 2). Subsequent competitions in gnotobiotic mice harboring permissive microbiota will allow us to deduce functions needed for colonization in the presence of a competitive microbiota. In aim 3, we will measure the impact of competitors transmitted from cohabitant to infected mice on the duration of ESBL E. coli carriage and assess potential synergies with the adaptive immunity in vaccinated hosts. Overall, we will unravel with unprecedented depth the general principles of intestinal colonization in ESBL E. coli, shed new light on the global success of prevalent clones and conceptualize robust antibiotic-free competition-based treatments.

Keywords: gut microbiota,vaccines,transmission,horizontal gene transfers
Repeat polymorphisms as genetic modifiers of brain function in healthy subjects and Huntington disease mutation carriers (BRAIN REPEATS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2017-09-30
Duration (months): 12.0
Total project cost (EUR): 97727.4
EU funding (EUR): 97727.4
Participants: 1
Project status: CLOSED

Neuropsychiatric disorders such as dementia and depression are among the leading causes of disability and exert a dramatic burden on Europe’s healthcare systems. In order to devise more effective therapies it is essential to elucidate their genetic basis. However, to date genetic association studies have only identified a small fraction of the genetic determinants, possibly due to neglect of some important genomic variations, especially DNA repeat expansions. Expanded DNA repeats above a certain threshold are associated with various neurological disorders, the most common of which are polyglutamine diseases caused by exonic triplet (cytosine-adenine-guanine (CAG)) repeat expansions leading to a range of cognitive and psychiatric abnormalities. Emerging findings indicate that even CAG repeat length variations in the normal range in polyglutamine disease-associated genes (PDAGs) can affect mental health and cognition. Nevertheless, virtually nothing is known about the biological mechanisms through which these genetic variations affect brain structure and function. Therefore, the key objective of this proposal is to evaluate the effects of CAG repeat polymorphisms in PDAGs on brain structure and function, both in healthy controls and carriers of the mutation for Huntington disease (HD), the most common polyglutamine disease. To this end I will: 1) Systematically assess the association between these genetic polymorphisms and mental health, cognition and brain morphometric and functional MRI imaging in a large cohort of well-characterized control subjects and HD mutation carriers, and 2) Perform pathway analysis using gene expression data already available from these participants in order to elucidate the underlying molecular pathways. This proposal is unique as it translates novel insights into the pathophysiology of polyglutamine diseases to those of more common, complex disorders, thereby accelerating development of effective therapies for all patient groups.

Keywords: huntington disease,cag repeats,polyglutamine disorders,depression,dementia