Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Glottalizations in German and Czech English (GECZENGLOTT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

The aims of this project are to analyse: 1) the extent of glottalization before word-initial vowels in German English productions and compare results with Czech English and British English productions, 2) the influence of glottalizations on word-recognition by Germans in comparison to Czech and native English subjects, 3) the influence of glottalizations on the perception of foreign accent by native English speakers. Research will be based on my previous work on glottalizations in Czech English. Glottalizations are sounds produced by the closing and abrupt opening of the vocal folds. In German and Czech, glottalizations are frequent before word-initial vowels and are a salient word-linking technique. In English glottalizations are less frequent. My previous analyses have shown that Czech speakers transfer this word-linking habit to their English productions and that glottalizations influence word recognition differently for Czech, English and Spanish subjects. Glottalizations will be analysed in German English productions and perception experiments will be carried out with German subjects, to investigate the influence of glottalizations on word recognition. Results will be compared to those previously obtained for Czech speakers. To test the influence of glottalizations on the perception of foreign accent, German English and Czech English data will be presented to native English subjects in perceptual experiments. If glottalizations contribute to the perception of accentedness, it would be useful to develop methods to teach non-natives how to overcome this characteristic in their pronunciation. At the Institute of Acoustics and Speech Communication of the Technical University in Dresden, I will be able to acquire new research competences on the resynthesis of speech, necessary to create the stimuli for the planned perception experiments. The project will reinforce my research abilities and be beneficial for my research career in the field of second language speech.

Keywords: second language,foreign accent,glottalization,speech perception,speech production
West and East: Textile technologies and identities in the 1st millennium B.C. South Italy and Cyprus (DIASPORA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 318514.6
EU funding (EUR): 318514.6
Participants: 1
Project status: CLOSED

Textile tools in the archaeological record provide significant yet so far unacknowledged information at three levels: (1) their shape and decorations highlight interaction between different cultural communities, (2) their findspots testify to the individuals' personal, occupational or gendered space in households and graves, and (3) textile tools' functional features illuminate the type of textiles that were once manufactured and thus visualise what has today been lost in the archaeological record. Textile tools are thus my key to the exploration of textile technologies and cultural identities in Iron Age contexts in South Italy and Cyprus, regions that have a mixed cultural heritage with Greek and Phoenician influx. The project utilises new textile tool analyses based on systematic experimental archaeology and introduces social agency theory for the first time in a textile context; this analysis of the textile producers and their tools will provide new knowledge to the discussion of socio-cultural dynamics and technologies in culturally mixed areas.

Keywords: humanities,iron age,textile tools,south italy,cyprus,hybridity,agency theory,textile technology
Predicting impacts of anthropogenic disturbance and biodiversity loss on emerging infectious diseases (DISTURBED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Emerging infectious diseases have substantial ecological, socio-economic and human health implications, yet factors determining their emergence and virulence are poorly understood. Recent studies have suggested ecosystem degradation and biodiversity loss significantly increase the emergence and prevalence of infectious diseases in animal communities. This is allied to global patterns of biodiversity which show substantial declines in response to anthropogenic pressures such as habitat loss and pollution. Thus, the proposed fellowship will investigate this theory that anthropogenic pressures results in biodiversity loss which then leads to increased disease emergence and transmission in animal communities. The research will utilise freshwater ponds, as these function as transmission foci for disease pathogens, respond quickly to anthropogenic disturbances, and have naturally high levels of biodiversity; disease emergence will be investigated in their fish communities. Objectives are to quantify measures of anthropogenic pressures and their impacts on pond biodiversity; identify how impacted biodiversity influences the emergence, transmission and virulence of infectious diseases in the pond fish community, and quantify the pathological and fitness consequences; and predict the patterns of emergence and transmission of infectious diseases according to current and future anthropogenic pressures. These objectives will be met through three research approaches: a field study conducted on natural ponds under different levels of anthropogenic disturbance; a field experiment using a gradient of fish biodiversity to identify its role in disease emergence; and predictive statistical modelling. The fellowship will provide invaluable research training and professional development of the applicant to support his future career as a European researcher.

Keywords: anthropogenic disturbance,aquatic biodiversity,emergence of infectious diseases,parasite community structure,pond ecology,north norfolk (uk),field and experimental research,predictive modelling
Design and synthesis of selective inhibitors of human lactate dehydrogenase 5 targeting the peculiar metabolism of glucose in tumours (LACTABLOCK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 193726.8
EU funding (EUR): 193726.8
Participants: 1
Project status: CLOSED

Highly invasive tumour phenotypes show a metabolic switch (“Warburg effect”) from oxidative phosphorylation to an increased glycolysis. This change in glucose metabolism, in favour of a less efficient process for production of energy and anabolites, confers several advantages on the tumour cells, such as the ability to grow in poorly oxygenated conditions, which are typical of invasive hypoxic tumours. One of the key enzymes actively involved in anaerobic glycolysis, the muscle isoform of human lactate dehydrogenase (hLDH5), was shown to be overexpressed by metastatic cancer cells, and has been linked to the vitality of tumours in hypoxia. This enzyme is currently being considered as a valid target for new anticancer agents, since its inhibition leads to a cut in cancer energy supply, thus reducing its metastatic and invasive potential. A validation of hLDH5 as a safe target derives from the observation that in humans, hereditary hLDH5 deficiency causes a certain level of myopathy only after intense anaerobic exercise, whereas it does not provoke any symptoms under ordinary circumstances. This project will support a qualified international researcher in the management of a research line including molecular design and synthesis of a series of new compounds, as well as in the participation in the biological evaluation of their properties. The host institution has already discovered a suitable structural scaffold, based on N-hydroxyheterocycles (NHIs), which has furnished some efficient hLDH5-inhibitors, possessing “first-in-class” potency and isoform selectivity. This scaffold will constitute the basis for the development of larger series of optimized NHI-analogues, as well as for appropriate variations of the central NHI-scaffold, leading to completely new classes of hLDH5-inhibitors, which will constitute more suitable pre-clinical candidates for the treatment of metastatic cancer.

Keywords: anticancer therapy,medicinal chemistry,pharmaceutical chemistry,chemical synthesis,organic chemistry,glycolysis,warburg effect,lactate dehydrogenase,enzyme inhibition,carbohydrate,metabolism
EVALUATING SUCCESS OF FLOODPLAIN FOREST RESTORATION (ESFFORES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-05-01
End date: 2016-04-30
Duration (months): 36.0
Total project cost (EUR): 268555.2
EU funding (EUR): 268555.2
Participants: 1
Project status: CLOSED

The acknowledgment of the importance of floodplain forests and their vulnerability to human impacts has raised them as an increasing focus of interest by the environmental legislation in Europe and across the globe. As a result, huge amounts of money are being invested worldwide in their restoration. However, very few studies have reviewed the success or failure of those efforts, which raises alarming uncertainties about their effectiveness and seriously jeopardizes the fulfillment of legislation objectives. The aim of this project is to develop tools to evaluate the success of past floodplain forest restoration projects according to ecologically-based quantitative criteria, with the ultimate purpose of giving experience-based prescriptions to land managers to optimize the resources devoted to the implementation of the current environmental legislation. To achieve this goal, a multi-scale field observation approach is proposed. Data on environmental, management and vegetation variables will be recorded in a series of restored, degraded and reference sites distributed across 2 semi-arid eco-regions of Western US and Southern Europe, with paired climatic gradients that cover different reaches of 6 large river basins (Middle Rio Grande, Arkansas, Upper Colorado, Tagus, Ebro and Garonne). For these sites, the capacity of abiotic variables as success predictors will be assessed on the base of different criteria representing ecological functionality, using cutting-edge multivariate statistical techniques. Leading scientists in the field of riparian restoration ecology will supervise the project in Europe and the US, within the context of well established research institutions well-suited to support the work. Given Dr. Eduardo González’s strong background and history of success, there is no doubt that with IOF fellowship support, the proposed project will greatly enrich his career, positioning him to make substantial contributions to environmental sustainability in Europe.

Keywords: habitat and species restoration and rehabilitation,riparian plant ecology,environmental policies,forest ecosystems,revegetation,river management,invasive species
A Dual Approach to Many-Valued Semantics (ADAMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-08-01
End date: 2015-07-31
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

Mathematical logic plays a crucial role in the 21st century society, indeed, in an era where information has become a key aspect of our lives, it provides a powerful mathematical framework for the study of the structure and the dynamics of information. A particularly interesting aspect of mathematical logic is that it allows to take in account uncertainty, vagueness or subjectivity, yet in the rigorous setting proper to mathematics. Drawn from the applications, disciplines like many-valued logic, modal logic, reasoning under uncertainty, etc. have quickly developed a weaponry of sophisticated investigation tools that enabled the disclosure of a number of substantial facts about their expressiveness, functionality and scope. Nonetheless the investigations in these topics are far from being concluded, rather they are ready to be shifted to another level which could take into account inter-relations between those topics and offer an exchange of knowledge and methodology among their practitioners. This project fits into this tendency shift, proposing an investigation of new semantics for many-valued logic with tools traditionally developed in modal and intuitionistic logic. Indeed, while the algebraic approach has enabled a fine comprehension of many-valued logic, leading in few years to a very reasonable framework of study, the time is mature for seeking new interpretations and concrete representations of these logical systems. As recent results put in evidence, the instruments developed in fifty years of studies on modal and intuitionistic logic, ranging from dualities to correspondence theory, are certainly the most qualified to help addressing this issues. The applicant has a strong background in many-valued logic and has already shown independency and vocation to research. The host institution, widely considered a pivotal research centre in modal and intuitionistic logic, is probably the best place in Europe to carry out such a research.

Keywords: mathematical logic,many-valued logics,algebraic logic,substructural logics,residuated lattices,modal logics,mv-algebras,canonical dualities,algebraic proof theory
Micro- and Macrocirculation Coupling: a cross sectional investigation of the cross-talk between the two circuits in insulin resistance states (MMC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 255069.4
EU funding (EUR): 255069.4
Participants: 1
Project status: CLOSED

Background: The human micro- and macrocirculation have distinct vital roles in the homeostasis of the cardiovascular system. There is a cross-talk between the two circuits to achieve the adequate vascular adaptations. Reciprocal transduction of ills signal between the micro- and macrocirculation may impair their optimal coupling and further accelerate vascular disease. In Europe the prevalence of insulin resistance (IR) (obesity and diabetes type 2) states and the related vascular damage and mortality is increasing rapidly. Main Scientific objective: to identify the early events in the natural history of chronic vascular disease of the micro- and macrocirculation in IR states and to investigate of the adaptive process of each circuit to the other in order to maintain optimal coupling. Specific scientific objectives: investigation of the cross-talk between wave reflections, pressure amplification, blood pressure phenotypes and blood flow patterns (conduit arteries, skin, muscle, retina) and their relation to the function and structure of large/small arteries, arterioles and cappilaries, endothelial function. Main training Objective: trained-through-research under supervision and hands-on training on microcirculation novel techniques; supervision of the investigations on macrocirculation. Study design: observational, population-based cross sectional study. Study population: random sample (1200 subjects) of Maastricht's area population with and without IR states, age 40-75. Microcirculation: skin videomicroscopy, retinamicroscopy, skin laser doppler and fourier analyses, muscle contrast-enhanced ultrasound,Macrocirculation: pulse wave analysis (mathematic applications-wave separation analysis), pulse wave velocity, carotid/brachial ultrasound, Other methods: All participants will be phenotyped by means of questionnaire, biood, urine, anthropometry, electrocardiogran and echocardiography. Expected results: to identify the very early events and the adaptive processes

Keywords: clinical medicine,microcirculation,macrocirculation,arteriosclerosis,blood pressure,blood flow,arterial properies,endothelial funcrion,remodelling,stiffness,amplification,wave reflections
Paris-Cracow-Venice. The European Festivals for Henri de Valois, King of Poland, 1573–74 (PARIS-CRACOW-VENICE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

The aim of the project is to provide the first multidisciplinary monograph and comparative analysis of one of the most splendid celebration in early modern Europe: the festivals staged for Henri de Valois, as king of Poland, in France, Poland and Italy before his accession to the French throne as Henri III. These lavish displays of the wealth and power of the monarchy were produced by the most acclaimed artists, musicians and dancers, working under the guidance of poets and humanists who were responsible for devising elaborate and erudite programmes. Carefully described and commented upon, the festivals provide us with incomparably rich resources to investigate the cultural and intellectual history of the early modern period. The festivals for Henri de Valois have been examined by many of the foremost scholars working on the Valois court. Until this time, however, no studies have given a comprehensive reconstruction and analysis of these festivals or provided a satisfactory interpretation of them. This survey, based on mostly unpublished primary sources in Latin, French, Polish and Italian, will engage with political history, art history, dance history, music history, and history of science and will be centred in literary history. The study will contribute to an understanding of how royal imagery was shaped and perceived in different parts of the continent, and they offer a new model for the study of Renaissance festivals, their meanings and their purposes. It will also raise the issues of the artistic, intellectual and political exchanges between France and Italy as well as between Western and Central Europe. The candidate, a Polish art historian specialised in French art, will be based at the Warburg Institute where she will receive an advanced training in interdisciplinary research on the European Renaissance, with a special reference to the sixteenth-century Italian culture and language.

Keywords: festivals,renaissance,art history,european literature,france,poland,italy,valois,history,humanities,history of dancing
Reconstruction of the post ’Little Ice Age’ geomorphological processes in glacial environments - sedimentological and morphological record of glacial landsystems’ reactions to environmental changes (GLACIRECON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-01-01
End date: 2014-12-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Sediments and landforms on recently deglaciated terrains are valuable archives of geomorphological processes. Thus, they can be used for reconstructions of the past and present behaviours of glaciers and ice sheets, which are very important indicators of environmental change. The GlaciRecon project focuses on deciphering of geomorphological process in marginal zones of selected modern glaciers, based on morphological and sedimentological evidences. The main scientific objectives of the project are: (1) Recognition and analysis of patterns of depositional and reworking processes of ice-marginal sediments and landforms; (2) Determination which factors have had the most significant impact on the transformation of glacial sediments and landforms since the end of the Little Ice Age (LIA); (3) Reconstruction of the evolution and assessment of preservation potential of modern ice-marginal sediments and landforms. Implementation of the project will help to identify the evolution of the glacial marginal zones at varied temporal and spatial scales. Analysis of different factors and their impacts on glacial landsystems’ transformations provide interpretations concerning the rate and style of glacial retreat linked with wider climatic implications. The realization of the GlaciRecon project improve the quality of local and regional stratigraphy, paleogeography and paleoclimate reconstructions concerning modern and the last glaciation in Europe and the rest of the world. The results of these reconstructions will contribute to the assessment of the impact of further climate changes on glacier/ice-sheet behaviour and global sea-level changes, which are important from a socio-economic point of view as they are used in quantification of resources threatened by sea-level rises. GlaciRecon is a multidisciplinary project linking varied geomorphological and geological methods with remote sensing and Geographical Information Systems (GIS).

Keywords: environmental science,earth science,environmental changes,glaciers,climate change impact (climate change),geomorphology,sedimentology,geoinformation