Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How do drug-associated contexts drive behaviour? The role of entorhinal circuitry in addiction (DrugsAndMemory)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1498475.0
EU funding (EUR): 1498475.0
Participants: 1
Project status: SIGNED

Addiction to drugs is a ubiquitous neuropathological disease that inflicts immense societal costs. A core aspect of addiction that poses a major challenge for treatment is the propensity to relapse in environmental contexts that are associated with drug use. Identification and mechanistic characterization of novel addiction-relevant circuitry linking the motivation to take drugs to the complex spatial and non-spatial features that constitute a drug-associated context are at the core of this proposal. These insights will be used to identify the best constellation of anatomical targets to prevent and reverse the expression of context-triggered drug-seeking. The medial and lateral entorhinal cortex (MEC and LEC) are two central components of the episodic memory system integrating all features relevant for the formation of contextual memory. Crucially, MEC and LEC receive strong bottom-up dopaminergic input from the midbrain and send top-down projections to the nucleus accumbens (NAc). The dopaminergic system is the primary target of all addictive drugs. We will 1) study how bottom-up dopaminergic projections are implemented into drug-context associations in MEC and LEC and 2) determine how these associations influence NAc-mediated drug-seeking behaviour. We will utilize a multidisciplinary approach by developing electrophysiological in vivo recording paradigms in behaving mice that allow the assessment of complex spatial, contextual and non-spatial codes in conditioned place preference and self-administration paradigms typically used to model addiction in rodents. This will be combined with optogenetically-assisted circuit analysis of molecularly-defined pathways to link identified functions to the underlying circuitry. Pathway-specific optogenetic silencing will be used to prevent and reverse the manifestations of drug use on a neuronal and behavioural level. This will guide the evidence-based development of therapies in the future, such as deep-brain stimulation.

Keywords: episodic memory,contextual memory,entorhinal cortex,reward,addiction,drugs,ventral tegmental area,motivation,nucleus accumbens,circuitry,optogenetics,behaviour,in vivo electrophysiological recordings
Pro-Kurdish Mevlid Commemorations in Turkey: Contested Understandings of a Popular Islamic Practice among Rival Ethno-Political Actors (HOLYBIRTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

This project is an inquiry into how actors strategically utilize religious repertoires and practices to articulate their political subjectivities. It mainly focuses on alternative mevlid celebrations organized by the rival factions of the Kurdish movement in Turkey, the Sunni Islamist Hizbullah and the secular ethnonationalist Kurdistan Workers’ Party (PKK), to commemorate the birth of Prophet Muhammad. Based on ethnographic fieldwork in Diyarbakir, the project will investigate how a local Islamic practice has become a contested political arena in Turkey’s predominantly Kurdish region, where rival nationalist interests and imaginaries compete for political dominance and legitimacy. Particular attention will be given to the conditions embedded in local power structures and everyday practices, which shape actors’ sense of identity and belonging. Drawing upon Bell’s theoretical exposition on "ritualization" and Connerton’s commemorative ritual theory, this project will offer a new perspective to investigate the intersection between religion and politics by analyzing a politicized ritual environment, in which various public expressions of Kurdish and Muslim identities are produced and disseminated. The methodological novelty of this project lies in its attempt to combine ethnographic inquiry with political science to shift the analytical focus from organizational and structural level explorations to daily human practice and interaction in social contexts.

Keywords: religion and politics,kurds,turkey,muslim rituals,identity,ethnicity,ethnography
Finding the Identifiable Species in Shagreen: multidisciplinary perspectives on marine shagreen and historical elasmobranch exploitation in Europe’s early modern period (FINS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: SIGNED

Marine shagreen is a luxurious, storied leather material made from the skins of elasmobranchs (sharks, rays, skates). Admired for being visually striking, waterproof, and conveying a sense of worldliness, shagreen became coveted by the wealthy and elites of 17th-19th century northwestern Europe. Crafted from shark or ray skin, once turned into shagreen, more precise taxonomic identifications are not possible. Provided the multinational origins, the elasmobranch species targeted span the Atlantic Ocean to the Indo-Pacific. Finding the Identifiable Species in Shagreen (FINS) aims to use a multimethodological approach to analyse museum objects and unveil which species of elasmobranchs were targeted for marine shagreen production in Europe’s early modern period. Historical archival research will be undertaken to refine our knowledge of anticipated target species while non-destructive and minimally destructive methods will be employed to directly analyse shagreen objects for taxonomic identifications. Understanding the historical exploitation, trade, and demand for elasmobranch skins in this time period, which coincides with the rise of industrialised fishing efforts, is critical and a timely endeavour to establish the ecohistory of these keystone taxa. One third of all elasmobranch species are classified as being threatened with extinction by the International Union for the Conservation of Nature. A key challenge to ongoing elasmobranch conservation efforts is the lack of historical data and ecological baselines. Through a combination of biocodicology, historical analysis, ecological research, interdisciplinary collaboration, and innovative approaches, we aim to provide valuable insights into the material culture, environmental history, and ecological dynamics related to elasmobranch exploitation during this period.

Keywords: historical ecology,elasmobranchs,early modern period,marine ecology,historical fisheries,marine conservation,marine resource exploitation
Scalable quantum algorithms in highly noisy environments (QSPEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 139953.6
EU funding (EUR): 139953.6
Participants: 1
Project status: SIGNED

Quantum computers bring the promise of solving efficiently problems that would take a considerable amount of time on the best classical computers. This is called the quantum speedup. However, an experimental proof of a quantum speedup on a problem useful for society remains to be shown. One of the main issues preventing it to occur is the noise: the hardware is too noisy which makes the algorithms outputs unreliable. These algorithms are usually designed under the assumption that the qubits are perfect, and the errors are corrected or mitigated “afterwards”. However, mitigation techniques are typically not scalable (they stop working if the algorithm is too large). Quantum error correction is scalable but very challenging to implement as it requires very high quality qubits. This project aims to design quantum algorithms that, by construction, would efficiently work in highly noisy regimes, because of a noise-aware design without the need for error correction or error mitigation techniques. Our first objective will be to see if it is possible to carefully design quantum algorithms (by looking at how errors propagate in the circuits) for which the consequences of the noise will be that the experimentalist has only to re-run the algorithm a polynomial number of times, naturally preserving any exponential speedup. Our second objective will be to study the possibility to design algorithms operating on mixed-states that do not introduce any entanglement but nonetheless provide an exponential speedup. Because such algorithms would work with mixed-states without entanglement, they could also lead to interesting noise-resilience properties. For both of our objectives, we will aim to find useful applications for our algorithms, beyond the mere proof of concepts. Overall, our project could lead to a new class of quantum algorithms, noise-resilient from their very design, and would provide fundamental insights on the necessary ingredients allowing a speedup to occur.

Keywords: algorithms,noise,nisq,scalability,entanglement,quantum error correction
New & improved EUSST Missions and Services. Horizon Europe TOP1 (HE_EUSST_MS_TOP1)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: Austria,Latvia,Netherlands,Poland,Portugal,Romania,Sweden,Czechia,Germany,Denmark,Finland,France,Greece,Italy,Spain
Call: HORIZON-CL4-SSA-SST-MS - New & improved EUSST Missions and Services (HORIZON-CL4-2023-SSA-SST-ART195, 2023)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 8000002.5
EU funding (EUR): 8000000.0
Participants: 21
Project status: SIGNED

This Horizon Europe grant is to be understood within a wider context on EUSST, where other grants are being executed simultaneously with the common objective of improving the EU autonomy on Space Surveillance and Tracking. In particular, this TOP focuses on: - Keep the knowledge and capabilities of Europe on the Space Surveillance and Tracking domain at the leading edge. - Adapt, improve and evolve the current EUSST initial services (Collision Avoidance; Fragmentation; Re-entry) portfolio to future user needs and space environment. - Improve the overall performance of the EUSST services and ensure, in the long-term, a high level of performance and appropriate autonomy at Union level. - Identify and define new missions and services (e.g. debris mitigation; debris remediation). - Explore the implementation of new services, in complement of the three existing ones. - Support the pre-developments and end-to-end early demonstration of new SST services. The starting point of these activities is the output of 2-3SST2018-20, which constitutes the state of the art on SST matters.

Keywords: eusst,sst,partnership,front desk,services,assets,sensors,radars,telescopes,lasers,catalogue,users,collision avoidance,re entry,fragmentation,survey,tracking,autonomy
A Sustainable Biocatalytic Alternative for Paracetamol Production (BioParacetamol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Current paracetamol production relies on century-old chemical methods that have significant environmental drawbacks, including high energy consumption, low process efficiency, and substantial waste generation. The BioParacetamol solution offers a more sustainable alternative by using enzymes to catalyse reactions at lower temperatures, producing fewer toxic by-products. This innovative process utilises a simplified one-pot, two-step synthesis, reducing energy demands, increasing efficiency, and minimising waste, particularly harmful by-products. Designed to be both scalable and commercially viable, BioParacetamol presents a major opportunity for the pharmaceutical industry to adopt greener chemistry practices. The BioParacetamol innovation is still in the early stages of development, with a technology readiness level (TRL) of 2, but aims to reach higher TRLs through rigorous testing and optimisation. The project’s primary goal is to demonstrate the feasibility of this process at an industrial scale, alongside a comprehensive business feasibility study to evaluate its commercial potential. BioParacetamol represents a high-risk, high-gain opportunity with the potential to not only improve the environmental footprint of paracetamol production but also position Europe as a leader in sustainable pharmaceutical manufacturing.

Keywords: aromatic hydroxylation,paracetamol,peroxygenase,
Startup of the SOILL support structure for SOIL Living Labs (SOILL-Startup)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Belgium,Italy,France,Denmark,Hungary,Spain,Sweden,Finland,Serbia,Poland,Greece,Netherlands,United Kingdom
Call: SGA: Specific Grant Agreement for a Living Lab Support Structure (HORIZON-MISS-2023-SOIL-SGA-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3200000.0
EU funding (EUR): 3200000.0
Participants: 30
Project status: SIGNED

The "A Soil Deal for Europe" Mission aims to accelerate the transition to healthy soils by 2030 through the establishment of 100 Soil Health Living Labs and Lighthouses (SHLL/LHs) that will drive the development and adoption of solutions. The Framework Partnership SOILL, led by ENoLL (the international association of certified Living Labs), has been created to coordinate, support, expand, and promote the network of 100 SHLL/LHs. During the initial two years of SOILL, the SOILL-Startup project will collaborate with the first waves of SHLL/LHs and key stakeholders to launch the SOILL one-stop structure. This involves: 1) Establishing a high-quality structure for SHLL/LHs with clear processes and procedures. A web-based Hub will be created to facilitate outreach, collaboration, support, and monitoring within and beyond the 100 SHLL/LHs network. 2) Providing comprehensive support to SHLL/LHs for a harmonized and sustainable approach within the network. This includes capacity building through training and supporting tools on methodologies, technical aspects, and cross-cutting areas. Regular monitoring and evaluation of SHLL/LHs will be conducted based on a consolidated assessment framework. 3) Supporting network expansion by promoting, engaging, matchmaking, and advising applicants to Mission calls. Events will be organized to showcase funding opportunities, provide examples, and disseminate information on the SHLL/LH concept and its implementation. Webinars, coaching, and matchmaking will assist applicants in conceptualization and consortia creation for their applications. 4) Facilitating knowledge exchange, collaboration, and synergy creation within the SHLL/LHs network and the wider community. SOILL-Startup will enhance the visibility and accessibility of the SHLL/LHs, their work, and achievements. Mutual-learning events, collaborative platforms, mutual visits, and matchmaking will facilitate collaboration opportunities, knowledge sharing, and solution uptake.

Keywords: one stop shop support structure,capacity building,engagement,promotion,support,knowledge exchange,matchmaking,synergies,collaboration,uptake,soil health living labs and lighthouses,launch
Immune Cell Death Zonation Regulated by Protein Hubs in Plants (ImmunoZoneHubs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: TERMINATED

Agriculture, which underpins the livelihoods of over 2.5 billion people, is nowadays confronted with an array of new threats including plant pests. This project tackles the urgent need to develop new, technology-based sustainable strategies to combat the constant agricultural losses and economic drain derived from plant pests, which have been worsened because of climate change. The understanding of the molecular and cellular mechanisms underlaying plant pathogen interaction and defence responses is not only a fundamental scientific challenge, but it is also relevant to practical applications. Despite decades of research on host-pathogen interactions, knowledge on fundamental aspects of the plant immune system is still missing. This proposal provides an excellent opportunity to help filling this gap of knowledge as it targets the question of how cells translate molecular pathogen recognition into immune cell death, and how dying cells and their neighbours communicate to tightly control this process and ensure the proper balance in between defence responses and plant growth and fitness. To address this question, I have designed a multidisciplinary and international project using Arabidopsis thaliana plant as a model system to study the molecular determinants of plant immune cell death zonation and the involvement of plant metacaspases, distant relatives of animal caspases, in cell death. A plethora of techniques including molecular and biochemistry techniques, plant phenotyping and engineering, FACS and cell biology microscopy techniques will be used for the proper execution of this project. In addition to generate high-impact knowledge in plant immunity that will ultimately impact on society, this proposal will provide me with the expertise, resources, training, and network to become extremely competitive in the field of molecular plant pathology, helping me to progress in my scientific career and to achieve my scientific goals.

Keywords: arabidopsis thaliana,immune cell death,cell death zonation,plant protein hubs,plant metacaspases,bacterial diseases and plant cell death,plant cell signalling,immune cell death facs
Bridging Greek Philosophy, Christianity, and Islam: An Edition of the Late Antique Testimonies of Heraclitus (BridgHe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

The chief objective of the project is to produce the first complete collection of the Late Antique testimonies concerning the early Greek philosopher Heraclitus. This source collection will include an English translation of the texts in the various relevant languages (mainly Greek and Arabic, but also Latin, Coptic, and Syriac) and a running commentary of the testimonies, highlighting both the philological and the philosophical importance of the Late Antique afterlife of Heraclitus. The project will thus also provide the very first in-depth study of the reception of the thought and the tenets of Heraclitus in this fundamental period. The name of Heraclitus was still resonating in third century Rome, fifth century Alexandria, and ninth century Baghdad, but no one has put together the existing evidence to tell that story yet. The main philosophical and exegetical objective of the project thus consists not only in the analysis of the various ways in which different authors have expounded the views and the sayings of Heraclitus, but also in the assessment of the remarkable patterns of continuity and change that characterise the Heraclitean interpretations in the broad chronological span of Late Antiquity. The figure of Heraclitus lies, indeed, at the intersection of historical periods and exegetical traditions that tend to be considered separately. My project aims to challenge this approach by showing that the literary and philosophical production pertaining to research fields such as Greek Philosophy, Christianity, and Islam has to be jointly taken into account if we want to understand both the interpretative history and the theoretical relevance of the tenets of Heraclitus. For this reason, the project includes not only the Greek reception of Heraclitus but also domains neglected by scholarly research such as the Gnostic writings of the Nag Hammadi library and the texts produced in the framework of the translation movement from Greek into Syriac and Arabic.

Keywords: ancient philosophy,classics,graeco arabic studies,islamic philosophy,presocratic philosophy,late antiquity,neoplatonism,christianity,gnosticism,religious studies