Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel bifunctional HAT catalysts for site-divergent C-H functionalizations mediated by photoredox catalysis (BICACH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The direct catalytic functionalization of C-H bonds, an ubiquitous motif in organic molecules, represents a paradigm shift in the standard logic of organic synthesis. One of the major challenges to render this approach synthetically useful is to control the site-selectivity because most organic molecules exhibit several similar aliphatic C-H bonds. The functionalization of aliphatic C-H bond mediated by photoredox catalysis is a highly active field of research. To date, state-of-the-art site-selective methods in this field rely on substrate control which are inherently restricted to the functionalization of a single C-H bond within the substrate backbone. The innovative aspect of this research program is to target catalyst control to allow the site-selective functionalization of several different C-H bonds of a single substrate. Through this approach, we wish to go beyond the challenging problem of site-selectivity to enable site-divergent functionalizations. Such a breakthrough would provide a new tool for a flexible and streamlined access to molecular complexity from chemical feedstocks. To achieve our objectives, we plan to develop novel bifunctional catalysts incorporating one moiety able to engage into dynamic non-covalent interactions with the substrate and another functional group able to perform Hydrogen Atom Transfer (HAT) processes. These two functional groups are connected by an inert spacer which will position the HAT unit in proximity to a particular C-H bond of the substrate, thus controlling site-selectivity for the C-H activation event. By varying the nature of the spacer, we expect to selectively functionalize several different positions of linear alkyl chains possessing almost undistinguishable methylene C-H bonds. Overall, BICACH aims at using simple bifunctional organocatalysts and light energy to trigger highly challenging C-H functionalization processes. In addition, it offers a unique training to the ER with broad future research perspectives.

Keywords: photoredox catalysis,bifunctional catalysis,c h functionalization
Enabling malaria rhomboid proteases as drug targets: usage of molecular cookie cutters to shape novel activity assays and inhibitors. (RHOMBOSMALPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Rhomboid proteases from P. falciparum, the causative agent of malaria, play a role in invasion of human red blood cells. The exact role of the individual members is challenging to track, because of difficulties in genetic manipulation of the P.falciparum and the inviability of some loss-of-function mutants. Hence, a chemical strategy is an attractive alternative. Unfortunately, the study of these eukaryotic rhomboids (PfROMs) has rendered impractical to date. The bottleneck is that the current purification techniques use detergents that eliminate the physiological membrane, yielding low enzyme stability and activity. In its turn, this rules out the use of activity assays and chemical probes to study their function. Encapsulating these proteins in their lipid environment will address these shortcomings. I will develop a detergent free purification method, based on a styrene maleic acid (SMA) polymer that functions as a “molecular cookie cutter”, creating SMA-lipid-protein nanodiscs, which retain their biological properties upon purification. Using this “molecular cookie cutter” to create lipid nanodiscs, I will isolate PfROMs and develop activity assays in order to identify and optimize novel inhibitors. The most potent and selective candidates will be evaluated in a malaria invasion model to verify the druggability of malaria rhomboids. Furthermore, these novel compounds may serve as leads for a new generation of therapeutic agents. The straightforward expansion of our approach to other intramembrane proteases may be the game-changer for drug discovery and future therapeutics directed against rhomboids from other species.

Keywords: intramembrane proteases,rhomboid,malaria,styrene maleic acid lipid particles,activity based protein profiling
SCIENTISTS FROM VARIOUS FIELDS TEACH US HOW TO CARE FOR THE PLANET ON A DAILY BASIS (NIGHTFOREARTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-07-01
End date: 2021-04-30
Duration (months): 10.0
Total project cost (EUR): 89989.5
EU funding (EUR): 89727.0
Participants: 8
Project status: CLOSED

During Researchers' Night in 2020 in Poznan our researchers will teach us how to care for our planet on a daily basis. Nowadays, ecological issues have become extremely significant. One can see a huge need to educate in ecology issues, but also a great interest of young people in this subject is observed. During the event, we will show how each field of science (technical and engineering, humanities, natural sciences, health sciences) can support ecology. See how scientists are building ecological solar vehicles, visit Sky Lab observatory, which enables observation of space debris, check how eco-friendly supercomputers work, discover what a green city of the future should look like, learn how to create ecological packaging. You will find that scientists are ordinary people and their work is really fascinating. The NIGHTFOREARTH builts on the expierence from the previous ones realised within last 13 years, with 2 new partners on board and new science fields invoved. Topics at individual Partners were selected in terms of the main message of the project which focuses on showing how we can care for the Earth in our every-day -life. Environmentally friendly solutions will be also adapted in the project's promotion and management. During each subsequent Reserachers' Night, public interest has been growing successive and new generations have become interested in science and scientists. This year's project aims to strengthen previous ones and shed light on new aspects of science. We want to spread the idea to the public at large, but specially to the young people that the work of scientists is a noble mission to save the planet, and it is worth learning from them. And all this thanks to science presented in a direct playful way (edutainment). We want Researchers' Night in 2020 to be a great feast of science, family fun (edutainment), as well as an attractive alternative to traditional Friday evenings activities.

Keywords: researchers night,edutainment,ecology matters,eco friendly,care for earth,eco lifestyle,research awareness
European Technology and Innovation Platform Bioenergy – Support of Advanced Bioenergy Stakeholders 2016 - 17 (ETIP Bioenergy-SABS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Italy,Italy,Austria,Germany
Call: Support to the energy stakeholders to contribute to the SET-Plan (H2020-LCE-2016-ETP, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 599105.0
EU funding (EUR): 599105.0
Participants: 4
Project status: CLOSED

The overarching aim of the Energy Union by 2030 and 2050 is a secure, affordable, competitive, efficient and decarbonised European energy system. Bioenergy is flexible and storable has a key role in providing all forms of energy in such a system. This project aims to support the contributions of biofuel and bioenergy stakeholders to the Energy Union and, more specifically, the Strategic Energy Technology (SET)-Plan. The project will assist the European Biofuels Technology Platform (EBTP), which, following decisions taken in the frame of the new SET-Plan governance in 2015, is currently preparing for the transition to a European Technology and Innovation Platform Bioenergy (ETIP Bioenergy), in providing these contributions. Key elements are to facilitate • contributions to the SET-Plan activities and strategy, e.g. on renewable energy integration, technology cost reduction and upscaling • defining priorities, strategies, R&I investment decisions and programmes; • collaboration between stakeholders in addressing energy system integration challenges; • identification of technical and non-technical barriers to the delivery of innovation to the energy market; • assistance to the European Commission and Member States in defining the research programmes, financial instruments, and addressing the mentioned barriers for the areas of advanced biofuels and bioenergy. Building on a 10 year track of support to EBTP, the ETIP Bioenergy-SABS project will aim at an increased cohesion of bioenergy stakeholders by motivating discussion and interaction on hot topics related to advanced and innovative bioenergy. Key instruments to achieve this aim will be the ETIP Bioenergy website, factsheets, reports, newsletters and networking events at different scales. The project will compile scientifically sound, fact based information on technical and non-technical bioenergy issues.

Keywords: biofuels,advanced biofuels,3rd generation,technology platform,bioenergy
European Network of Research Ethics and Research Integrity (ENERI) (ENERI)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Austria,Germany,Norway,Finland,Greece,Lithuania,Netherlands,Netherlands,Denmark
Call: European Ethics and Research Integrity Network (H2020-GARRI-2015-1, 2015)
Start date: 2016-09-01
End date: 2019-10-31
Duration (months): 38.0
Total project cost (EUR): 1499000.0
EU funding (EUR): 1499000.0
Participants: 12
Project status: CLOSED

The “European Network of Research Ethics and Research Integrity” (ENERI) establishes an operable platform of actors in the fields of research ethics and research integrity. The reliability and credibility of research and science do not depend only on its excellence and productivity but also on the players’ awareness of highest standards of ethics in research and commitment to a responsible conduct of research. Research ethics addresses the application of ethical principles to the various fields of research. This includes ethical aspects of the design and conduct of research, the way human participants or animals within research projects are treated, and aspects of scientific misconduct. Research integrity is recognized as the attitude and habit of the researchers to conduct research according to appropriate ethical, legal and professional frameworks and standards. The fields of research ethics and research integrity combine general ethical reflections, ethics and law as academic disciplines addressing research activities, moral attitudes of researchers, normative policies of stakeholders like sponsors or funding organizations, and various ethical expectations of the civil society. ENERI is based on existing networks, projects and infrastructures that already initiated and developed important steps in sharing information, training and capacity building. Research ethics committees, review boards, ombudspersons’ offices, research integrity offices and supporting structures are the established bodies monitoring, accompanying and assisting the process of responsible and justifiable research. Therefore the European Network of Research Integrity Offices (ENRIO) and the European Network of Research Ethics Committees (EUREC) mutually initiated ENERI in collaborations with experts in academic research ethics (RE) and responsible research and innovation (RRI), practitioners in training and education in research ethics, and specialists in e-communication and database design.

Keywords: research ethics committtees,research integrity offices,network,ethical standards,good scientific practise,reliability,transparency,data protection
RESEARCHERS' NIGHT in ROMANIA. Do you speak science? (RoTalkScience)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania,Romania,Romania,Romania,Romania,Romania,Romania
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 118316.25
EU funding (EUR): 118316.0
Participants: 10
Project status: CLOSED

The general objective of the project is to promote scientific research in Romania and to share to general public the enthusiasm of professionals working in this field. Our approach for this national coverage event is to present science and scientists in a non conventional way, employing edutainment methods. The easiest way for the public to learn about science and research is to experience things and to remember amusing scientific experiments or demonstrations. Similar activities, conducted in a regular manner should be a trigger for the pupils and students to consider a career in research following graduation. Our event will take place in 6 cities: Bucharest, Craiova, Cluj-Napoca, Iasi, Sibiu and Timisoara, and are organized by enthusiastic teams from Universities and research Institutes. The gravity point of all proposed activities is represented by various open air activities, organized in an amusing manner by real scientists and students. Furthermore we would like to stress the importance of scientific research for a modern society and to share information on major research infrastructures in Romania (e.g ELI project). European Research Area and the program Horizon2020 will be presented interactively at EU corners. The target audience for all locations include pupils, students, teachers, parents and grand parents, with special attention devoted to gender equality. We will attract pupils and parents from rural regions, kids with special educational needs, kids from the gifted education programme and theirs trainers. Special tours will be organized for policy makers in educational area, science teachers and science journalists. By means of a well developed media plan, including social media tools, during the awareness campaign we expect that more that 700000 people will know precise data about our project: locations, hours, proposed activities. In all proposed locations we expect a total number of participants higher than 20000 people.

Keywords: edutainment,national coverage,eu research area
Proteomic fingerprinting of functionally characterized single synapses (FunctionalProteomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Hungary
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

Our astonishing cognitive abilities are the consequence of complex connectivity within our neuronal networks and the large functional diversity of excitable nerve cells and their synapses. Investigations over the past half a century revealed dramatic diversity in shape, size and functional properties among synapses established by distinct cell types in different brain regions and demonstrated that the functional differences are partly due to different molecular mechanisms. However, synaptic diversity is also observed among synapses established by molecularly and morphologically uniform presynaptic cells on molecularly and morphologically uniform postsynaptic cells. Our hypothesis is that quantitative molecular differences underlie the functional diversity of such synapses. We will focus on hippocampal CA1 pyramidal cell (PC) to mGluR1α+ O-LM cell synapses, which show remarkable functional and molecular heterogeneity. In vitro multiple cell patch-clamp recordings followed by quantal analysis will be performed to quantify well-defined biophysical properties of these synapses. The molecular composition of the functionally characterized single synapses will be determined following the development of a novel postembedding immunolocalization method. Correlations between the molecular content and functional properties will be established and genetic up- and downregulation of individual synaptic proteins will be conducted to reveal causal relationships. Finally, correlations of the activity history and the functional properties of the synapses will be established by performing in vivo two-photon Ca2+ imaging in head-fixed behaving animals followed by in vitro functional characterization of their synapses. Our results will reveal quantitative molecular fingerprints of functional properties, allowing us to render dynamic behaviour to billions of synapses when the connectome of the hippocampal circuit is created using array tomography.

Keywords: synaptic neurotransmission,hippocampus,immunohistochemistry,patch clamp,electrophysiology,two photon imaging
The Sound of Empire in 20th-c. Colonial Cultures: Rethinking History through Music (MUSICOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France,France,France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2026-04-30
Duration (months): 78.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2040141.25
Participants: 5
Project status: SIGNED

To better understand cultural relations in today’s multi-ethnic, multicultural societies, we need to revisit the legacy of modern empires. This project delves into the musical dimension of the French empire and what differences were negotiated through aurality, long-neglected by historians. Focusing on musical life and media from Dakar and Rabat to Saigon, 1900-1962, it studies how music was practiced, heard, and understood in a variety of colonial contexts. Crucially important is the need to investigate the tastes, practices, and interactions of Europeans and natives, usually studied in isolation. Such scope requires an entirely new methodological paradigm: relational, comparative, and integrative-synthetic. Traversing disciplinary boundaries separating musicology from history, media studies, and ethnomusicology, the project has four objectives: (1) To musicalize history, it probes what musical fields of production contribute to current debates on the nature of empire and colonial identities. (2) To historicize aural media, it examines live and recorded music on radio as windows on the dynamic nature of colonial coexistence. (3) To globalize music history, it brings new coherence with its focus on a single empire and without imposing postcolonial models of domination/resistance. (4) To creolize research, it integrates indigenous research and promotes dialogue with collaborators from the former empire. Foundations laid by the PI’s prior research in colonial archives, availability of sources, each team member’s expertise and focus on one field, their shared method, and common purpose insure its feasibility. This pioneering study of the modern French empire through music will generate new insights into its mechanisms and constituencies, taking colonial, media, and music history in unprecedented directions. Only in understanding the aurality of colonialism--what helped their imperialism take hold and last--can Europeans grasp its full nature, meaning, and legacy.

Keywords: colonial radio history,colonial governance,urban spaces,french empire,concerts,musical networks
Body Imagery and Posture Effects in Development and Learning (BIPEDAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-10-10
End date: 2025-10-09
Duration (months): 36.0
Total project cost (EUR): 257561.28
EU funding (EUR): 257561.28
Participants: 2
Project status: SIGNED

This Fellowship aims to study the role of infants' motor and body representations in the development of action perception. Existing research indicates that infants' abilities to predict others' actions and imitate their goals may be precursors to social cognition - the ability to infer the mental states of others. Although the contribution of sensorimotor processes to infants' action perception is the subject of ongoing research, little existing research has explored the inherently embodied nature of sensorimotor action representations in light of the extensive physical and motor development during infancy. The objectives of the proposed research are to examine infants’ sensorimotor representations of the body, how these representations are affected by the development of new motor skills, and how inhibiting access to a mental representation of their own body affects infants’ perception of action. A novel contribution of the research will be the Fellow’s training in and application of magnetoencephalography (MEG) to infant action perception. This method is particularly relevant to the research, as MEG’s spatial resolution enables investigation of topographic neural activation. This will tell us if infant neural sensorimotor responses to observed action involve representations of the parts of the body used in the action. Established methods in developmental psychology (preferential looking, electroencephalography) will also be used, along with a new application of a posture manipulation paradigm to an infant population. The scientific outcome of this fellowship will be improved understanding of early social cognitive development via the incorporation of own-body representation into existing theories of developmental action perception. The impact of the outgoing phase will be to equip the Fellow with specialist technical skills in developmental research, particularly developmental MEG. These skills will be transferred to Europe in the return phase.

Keywords: action perception,infancy