Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Maritime Integrated Surveillance Awareness (MARISA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Italy,Germany,Finland,Belgium,Greece,Belgium,Greece,France,France,Netherlands,Portugal,Portugal
Call: Data fusion for maritime security applications (H2020-SEC-2016-2017-1, 2016)
Start date: 2017-05-01
End date: 2020-02-29
Duration (months): 34.0
Total project cost (EUR): 9765658.75
EU funding (EUR): 7997492.5
Participants: 23
Project status: CLOSED

Combating irregular migration, human smuggling, terrorism at sea, piracy, as well as arms and drug trafficking has become a high priority on Europe’s security agenda. Securing the sea requires a day-to-day collaboration activities among European actors of maritime surveillance, Member States’ administrations and European agencies principally, and a significant number of initiatives are being taken at EU level to address this challenge. The large amount of ‘raw data’ available today are not usable by systems supporting maritime security since they are not accessible at the same time and, often, they are not interoperable. Therefore, the overarching goal of MARISA project is to provide the security communities operating at sea with a data fusion toolkit, which makes available a suite of methods, techniques and modules to correlate and fuse various heterogeneous and homogeneous data and information from different sources, including Internet and social networks, with the aim to improve information exchange, situational awareness, decision-making and reaction capabilities. The proposed solution will provide mechanisms to get insights from any big data source, perform analysis of a variety of data based on geographical and spatial representation, use techniques to search for typical and new patterns that identify possible connections between events, explore predictive analysis models to represent the effect of relationships of observed object at sea. Enterprise and ad-hoc reporting and services, within the CISE context, will be provided to support users and operational systems in their daily activities, as well as presentation tools for navigating and visualizing results of data fusion processing. The involvement of 5 practitioners as full partners will allow on the one hand to align innovation to user needs, on the other hand to validate the toolkit through a number of trials addressing cross country/cross domain applications.

Keywords: enhanced data fusion,innovative data fusion services,end user driven validation,operational trials,cross border,cross national collaboration,big data sources,cise compliance,agile
Quantum Energy Conditions and Singularity Theorems (QuEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed project explores an important open question in mathematical physics today: the occurrence of singularities in spacetime - places where the usual understanding of physics breaks down. For example, singularities may exist at the center of black holes, or have occurred at the beginning of the universe. Singularity theorems, developed over the past 50 years following pioneering work of Penrose and Hawking, are mathematically rigorous results that imply that singularities are inevitable provided the matter content of the universe obeys a suitable energy conditions. Although forms of matter described by quantum field theory can violate the original energy conditions, recent developments provide hope that singularity theorems can be proved even in this case. To date, however, no known singularity theorem fully corresponds to the behaviour of quantum fields or takes into account the backreaction of the quantum field on the spacetime. The goal of this project is to establish singularity theorems for quantised matter using recent work by the researcher and the supervisor as a base. This will be approached in several ways (a) new quantum energy inequalities will be proved that are suitable for use in singularity theorems; (b) new singularity theorems will be proved using a transversely smeared version of the averaged null energy condition; (c) analogues of singularity theorems will be investigated in the context of semiclassical gravity. The combination of the complementary expertise of the researcher and the supervisor is essential to the success of this project. Moreover the researcher will receive training from the supervisor in mathematically rigorous approaches to quantum field theory and relativity, which will broaden her knowledge and expertise. This project will help to resolve a major problem in mathematical physics today and provide insight into how the universe works.

Keywords: quantum fields in curved spacetime,singularity theorems,quantum energy inequalities,semiclassical gravity
Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Action type: Specific Grant agreement
Countries involved: Austria,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Italy,Italy,Italy,Italy,Israel,Austria,Germany,Italy,Italy,Italy,Switzerland,Switzerland,Switzerland,Switzerland,Switzerland,Norway,Norway,Türkiye,Belgium,Belgium,Belgium,Belgium,Finland,Finland,Greece,Greece,Hungary,Sweden,Sweden,Sweden,Switzerland,Hungary,Slovenia,France,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,Portugal
Call: FETFLAGSHIP (H2020-Adhoc-2014-20, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 89000000.0
EU funding (EUR): 89000000.0
Participants: 140
Project status: CLOSED

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBP’s first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.

Keywords: mouse brain,human brain,transcriptome,simulation,reconstruction,neuroinformatics,biological,signatures of disease,high performance computing,neuromorphic computing,neurorobotics
Interplay of plant one-carbon metabolism and redox homeostasis in the context of dynamic DNA methylation (DYNAMET) (DYNAMET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

DNA methylation patterns in natural population are influenced by environmental factors and may be involved in selection of complex traits. Accordingly, there is growing interest to exploit epigenetic variation for crop improvement, a goal of utmost social importance considering the rapidly expanding world population and agricultural challenges from climate change. To better assess the use of epigenetic variation for crop improvement, it is crucial to know more about the dynamics of DNA methylation and the involved mechanisms. DNA methylation is stably maintained during DNA replication to faithfully silence transposable elements and thereby ensure genome integrity. However, recent studies indicate that DNA methylation changes in plants that have been caused by environmental factors, including pathogens, heat, and drought may contribute to resistance against recurring stress. The aim of this proposal is to further elucidate the regulatory mechanisms of dynamic DNA methylation and their effects on plant fitness under environmental stress. We will address this aim by studying the interaction of one-carbon (C1) metabolism, redox homeostasis, and epigenetic regulation. C1 metabolism provides the methyl donor S-adenosylmethionine required for DNA methylation. Accordingly, perturbations in C1 metabolism can drastically affect genome-wide DNA methylation patterns and transcriptional gene silencing. C1 metabolism is tightly connected to redox homeostasis and key enzymes in C1 metabolism are regulated by redox-dependent post-translational modifications. Notably, redox changes are hallmarks of stress responses. Therefore, our objective is to investigate how stress-induced redox changes are linked to alterations in C1 metabolism and epigenetic regulation in the model plant Arabidopsis thaliana and in barley. The interdisciplinary approach will facilitate the discovery of new regulatory mechanisms involved in plant acclimation and reveal their potential in crop improvement.

Keywords: dna methylation,nitric oxide signaling,one carbon metabolism,redox,plants,stress,arabidopsis,barley
Novel recycling and reprocessing of permanent magnets (OCARINA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-04-19
Duration (months): 24.0
Total project cost (EUR): 150040.32
EU funding (EUR): 150040.32
Participants: 1
Project status: SIGNED

The transition to a low carbon society and energy efficiency by 2050 (“The EUs Green Deal”) will require radical solutions, especially in order to reduce greenhouse gas emissions, which have to be reduced by 80%. The major contributing segments are the development of e-mobility and eco-power generation, which will need highly efficient electric motors to meet the target. This can only be achieved by using high-performance rare earths-transition metal permanent magnets (RE-TM PMs) like Nd-Fe-B in such motors and generators. From this perspective, RE-TM PMs are an important subject of further research with aiming at even improved properties and performances. However, REs are on the EU's list of most critical raw materials, which requires holistic measures encompassing their recycling that will in the future accompany their primal development. There is already a large pool of RE-TM PMs based applications that are already at their end of life (EOL) (hard disk drives for example), the new e-applications like electric vehicles and wind turbines that are about to come to their end of life in the near future. However, the current recycling is too expensive for the EUs to conduct so, that is why the proposed project “nOvel reCycling And ReprocessIng of permaNent mAgnets”- OCARINA proposes a new feasible recycling technology of EOL magnets that would reduce EU dependence of RE imports. With this we are killing two flies in one run, as the new recycling route offers to tailor and improve the magnetic properties inside out, that was up to now impossible. ER is to tackle the proposed thematic is hosted by the Jožef Stefan Institute (JSI), Department for Nanostructured (K7) materials, where the complementary and synergetic knowledge are used for the project success.

Keywords: permanent magnets,nd fe b,end of life,recycling,reprocessing
Nanoscale 3D Printing of a Lithium Ion Battery: Rethinking the Fabrication Concept for a Revolution in Energy Storage (NANO-3D-LION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2027-01-31
Duration (months): 72.0
Total project cost (EUR): 2255055.0
EU funding (EUR): 2255055.0
Participants: 1
Project status: SIGNED

One of the greatest technological challenges of today is efficient storage of electrical energy for portable applications, including electric vehicles, mobile electronic devices, and robotic systems. Further progress in these areas, however, is often hindered by the limitations of current rechargeable lithium ion battery technologies, which are among the most common power sources for these systems. Despite tremendous progress in electrode materials, the intrinsic drawbacks of current batteries are related to their planar two-dimensional design, which restrains the performance in terms of output power and charging speed. NANO-3D-LION is aimed to make a breakthrough in these major battery characteristics by a paradigm shift in battery engineering: the goal is to develop and employ advanced nanoscale 3D printing techniques to fabricate active battery materials with ultrasmall structural features, which will provide almost a thousand-fold increase in the surface area of the battery enabled by nanoscale spacing between its electrodes without compromising the battery capacity. To reach this, high-aspect ratio metal features will be fabricated and further converted into the active material of the cathode and the anode. This will enable unprecedented level of control of the battery architecture, allowing groundbreaking improvement of the key battery performance characteristics, including higher output power and charging times of only several seconds. NANO-3D-LION will establish a unique engineering approach with a potential to completely change the future landscape in research and industry related to portable electronic devices and electric vehicles and will also benefit many technologies beyond battery research, where nanoscale 3D printing opens new unparalleled capacity, therefore ensuring its broad scientific, economical and societal impact.

Keywords: additive manufacturing,nanoscale printing,lithium ion battery
Mechanical Aspects of Hydra Morphogenesis (HydraMechanics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Morphogenesis is one of the most remarkable examples of biological pattern formation. Despite substantial progress in the field, we still do not understand the organizational principles responsible for the robust convergence of the morphogenesis process, across scales, to form viable organisms under variable conditions. We focus here on the less-studied mechanical aspects of this problem, and aim to uncover how mechanical forces and feedback contribute to the formation and stabilization of the body plan. Regenerating Hydra offer a powerful platform to explore this direction, thanks to their simple body plan, extraordinary regeneration capabilities, and the accessibility and flexibility of their tissues. We propose to follow the regeneration of excised tissue segments, which inherit an aligned supra-cellular cytoskeletal organization from the parent Hydra, as well as cell aggregates, which lack any prior organization. We will employ advanced microscopy techniques and develop elaborate image analysis tools to track cytoskeletal organization and collective cell migration and correlate them with global tissue morphology, from the onset of regeneration all the way to the formation of complete animals. Furthermore, to directly probe the influence of mechanics on Hydra morphogenesis, we propose to apply various mechanical perturbations, and intervene with the axis formation process using external forces and mechanical constraints. Overall, the proposed work seeks to develop an effective phenomenological description of morphogenesis during Hydra regeneration, at the level of cells and tissues, and reveal the mechanical basis of this process. More generally, our research will shed light on the role of mechanics in animal morphogenesis, and inspire new approaches for using external forces to direct tissue engineering and advance regenerative medicine.

Keywords: morphogenesis,active matter,active nematics,actomyosin cytoskeleton,collective cell migration,mechanical feedback,mechanical self organization
The industrialization and market entry of a novel bioengineered hydrogel grid to standardize stem cell cultures for precision medicine. (Gri3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Switzerland
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ability to generate miniature organ models in a dish, termed organoids, from patient stem cells has opened endless possibilities for applications in precision medicine. SUN bioscience SA, a spin-off company of EPFL in Switzerland, was founded in 2016 with the ambition to move these organoid cultures from basic research to the Health Care industry. To reach this goal, SUN bioscience has developed Gri3D, a microstructured biocompatible hydrogel platform, and aims to establish this technology as a new standard for growing organoids at industrial scale and precision. Gri3D prototypes have been field tested with over 30 European academic and pharmaceutical R&D groups. In addition, SUN bioscience has developed an industrial automated manufacturing mechanism for Gri3D that is now being translated into the world-wide first machine, Hydra I, that auomates liquid handling with hydrogel microembossing. The objective of this feasibility study is to verify the technical, economical and practical viability of Gri3D and to ensure its successful market entry in Europe. Specifically, the first step is to validate the production capacity of Hydra I by producing 1’000 Gri3D units, which corresponds to one tenth of the total annual target production volume. In a second step, SUN bioscience aims to validate the market by commercializing these 1’000 Gri3D units to existing customers and to expand its customer base to a total of 20-40 recurrent clients. According to our current strategy, SUN bioscience will run at maximum single line production capacity with cumulative revenues of >€2M within 3 years after market introduction of Gri3D. The 3D technologies market is expected to reach €600M by 2021. The long-term business objective is to implement organoid assays on Gri3D and to establish SUN bioscience as a leader in clinical diagnostics with the intention to initiate a phase 2 SME instrument project along this path.

Keywords: microstructured biocompatible hydrogels,microembossing,stem cell organoids
Improving the Treatment of Head and Neck Cancer without Additional Side Effects (HyperCollar3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Head and Neck (H&N) cancer is the 6th most frequent cancer and the average 5-year survival following the diagnosis is below 50%. Radiation therapy (at times combined with chemotherapy) is currently the most common method to tackle H&N cancer. Yet, its effectiveness goes hand in hand with its toxicity levels, and hence its side effects. Our mission at Sensius is making the treatment of H&N cancer more effective without undesirable additional side effects. And the key innovation to achieve this mission is hyperthermia. There are numerous scientific evidences that warming up the tumor to about 42 °C improves its sensitivity to the radiotherapy treatment. In fact, there are already multiple solutions of the market offering devices for hyperthermia working on several types of cancer, but not for H&N cancer. Our HyperCollar3D is the first device based on hyperthermia for H&N cancer. The HyperCollar3D has been tested by over 70 patients at the Erasmus Medical Center in Rotterdam with excellent results: patients have a 50% higher chance to be cured when hyperthermia is used as a complement of radiotherapy. These results have been validated by the scientific community, published on peer- reviewed medical journals and presented at scientific conferences. This innovation has a huge business potential: only in EU & USA markets we could have about 50,000 new users every year. Other manufacturers already commercialize hyperthermia solutions for cancer treatment, but none of them focuses on H&N cancer because this area is complicated to treat. The IP of the HyperCollar3D has been protected with a European patent. The team behind the HyperCollar3d is top notch: the five founders of Sensius are a mix of medical, technical, and business expertise and they together wield decades of experience in high-tech product development, marketing of medical technology, and medical solutions based on hyperthermia.

Keywords: head and neck cancer,hyperthermia,adjuvant cancer treatment