Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High performance yarn for public transport, home textiles and protective wear (HIPER-YARN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project represents a breakthrough innovation for EGARFIL as it aims to introduce to the market HIPER-YARN, a new product, which represents a technological advance in the field, not comparable with state-of-the-art solutions. HIPER-YARNs are advanced composite textile materials that EGARFIL developed driven by the market need of yarns resistant to cutting for anti-vandal applications, in particular for public transportation seating upholstery. Bus and train operators spend millions each year to repair vandal acts across the EU that could be reduced by using high resistance and cut-proof yarns in their textile seating upholstery. HIPER-YARN has a performance outclassing current yarns available in the market (50% more resistance, 40% more durable). It is manufactured by using the worsted spinning process while current products are made of filament yarns or by using the cotton spinning process. The unique selling points of HIPER-YARN are: (a) high performance surpassing those of continuous filament yarns, (b) better aesthetics and touch feeling, (c) increased durability and (d) significantly lower cost both by the composition and due to its easier downstream processing ability HIPER-YARN has the potential to enter several high-end markets (MOBILTECH, HOMETECH and PROTECH). A total of 9 current customers (national and EU) are interested in HIPER-YARN and there are 21 more identified which are not customers at this moment, but are potential consumers. Estimated target sales for HIPER-YARN are to reach 8.4M€ in 2024 in this sector with a profit of 1M€ based on a 12% gross profit margin after an additional investment of 550k€ (3.7 ROI). This expansion will create 9 full-time jobs in EGARFIL from 2021 to 2024. The main result of phase 1 will be the feasibility study including a business plan. This will enable EGARFIL better assess the market opportunity, technical requirements and viability, identify key players and establish initial contacts with key stakeholders.

Keywords: yarn,advanced materials,composites,vandal proof,technical textiles,textiles,fibres
The Evolutionary and Developmental Origins of Inquiring Minds: Studies of Causal Reasoning; Curiosity and Executive Control (INQMINDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Human technology is vastly superior to that of other apes: human tools from telescopes to the Large Hadron Collider exploit causal relationships but also explore them. What change over the brief course of hominid evolution made for such a big difference? One theory implicates a single cognitive distinction: the ability to reinterpret the world in abstract terms. In contrast, in several studies, chimpanzees seemed to rely on surface appearances, as if for the apes there was no more to the situation than met the eye. The theory is seductively simple, but this proposal argues that it is too early to rule out deep evolutionary roots for inquiring minds. Experiments designed specifically to compare humans and other primates are proposed covering two broad lines of study: causal cognition and executive function. To disentangle causal reasoning from simpler mechanisms three approaches are planned. The first will look at intervention: will subjects use exploration to seek hidden causes? The second will focus on natural mechanics: do subjects reason about physical properties or rely on perceptual correlates? The third examines causal learning from observation when the task’s mechanics are opaque. The second line of study explores executive functions. An inquiring primate mind could flourish if more information could be held in mind and manipulated. But we know little about how executive functions compare across primates. A new test battery will explore levels of working memory, inhibition, and attention shifting. Executive functions undergo radical development in human childhood, and individual differences correlate with performance on tests of physical and social reasoning. The intersection between these skills may therefore be particularly revealing. This proposal aims to use cross-sectional testing of causal cognition and executive control in the same individuals to explore how these cognitive skills interact to produce inquiring minds.

Keywords: cognition,causal learning,developmental psychology,comparative psychology,executive function
MUltiSectoral Integrative approaches to CArdiac care (MUSICARE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Italy,Italy,Belgium,Belgium,Belgium,Netherlands,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3835204.56
EU funding (EUR): 3835204.56
Participants: 15
Project status: CLOSED

MUltiSectoral Integrative approaches to CArdiac care – MUSICARE - is proposed by a team of universities, companies and hospitals from 4 EU countries (Italy, United Kingdom, The Netherlands, Belgium). The main scope of MUSICACARE is to structure a new trans-sectoral and multidisciplinary network capable of developing research and technology with no barriers between academia, industries and clinicians in the cardiac arena, and of shaping young researchers with a novel and truly multidisciplinary mindset, capable of developing clinical- and business-oriented technology including tools for the advancement of base knowledge. MUSICARE activity will impact on the field of cardiac surgery in three ways: i) from a scientific standpoint, new knowledge will be gained regarding the response of tissues to their surgical reshaping, to the implantation of devices and to drugs; ii) from a technological standpoint, new technologies will be developed to improve the design and generation of new clinical solutions, the clinical training, and image-based diagnosis and prognosis; iii) from an educational standpoint, a new paradigm of PhD track will be implemented, which will combine academic research in the field of biomedical engineering with industrial research activities and with on-the-field activity within clinical infrastructures. This novel PhD track will be accessed by 15 Early Stage Researchers (ESRs) recruited in the project by universities (7) and companies (8).

Keywords: percutaneus treatment,trascatheter procedures,patient specific imaging,tissue modelling
Characterising the spatial organisation and regulation of the Wnt receptor complex in stem cells and cancer (WntTraffic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Wnts are a family of secreted glycoproteins that control maintenance and proliferation of stem cell reservoirs during tissue homeostasis and regeneration after injury. Deregulated Wnt signalling due to mutations in important signalling intermediates is strongly linked to disease. The complex molecular mechanisms mediating Wnt-induced cell responses are therefore of wide interest and the underlying protein interactions provide attractive drug targets, particularly in regenerative medicine and cancer treatment. The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. The key objective of this proposal is to resolve critical molecular events that drive initiation of the Wnt cascade in stem and cancer cells. By using a novel tool developed in the Maurice laboratory to detect endogenous Wnt-bound complexes, The Applicant will focus on the following central objectives: 1. To elucidate Wnt receptor localisation in sub-cellular compartments 2. To examine the regulation of Wnt receptor trafficking and turnover in response to Wnt signalling 3. To investigate how cancer cells exploit Wnt receptor trafficking to drive tumour growth To meet these objectives, The Applicant will be trained to employ an integrated approach combining biochemistry and genome editing in intestinal organoid cultures with advanced imaging including immuno-electron microscopy to develop a unique set of tools to study Wnt receptor trafficking and turnover at the endogenous level. The expected insights will be vital to understand how pathway activation is controlled and for strategies to interfere with Wnt signalling in disease.

Keywords: wnt signalling,protein trafficking,endocytosis,ultrastructural analysis electron microscopy,protein engineering,genomic editing,cancer
Race-based health care: A comparative study of the use of race-based diagnostics in Europe (RaceCareEurope)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 267480.0
EU funding (EUR): 267480.0
Participants: 1
Project status: TERMINATED

Inclusion and diversity are currently topical subjects in health research, care and policy in Europe. In recent years there have been calls at the national and EU-level for health care professionals, health researchers and policymakers to attend to diversity and inclusion in health care, research and policy. Here, in addition to gender, migration, sex, religion, language, SES, education, and sexuality, ethnicity and race have become focus points within this so-called inclusion paradigm. With regard to race, one way in which inclusion and diversity has been approached in health care is to introduce race-based health diagnostics. These are diagnostic techniques, tools, and calculations in which different actions are included for different 'racial' groups. 'Race' is, however, a highly contested construct, of which the use in research and medicine has been highly debated, especially in the US. The recent introduction and use of race-based health diagnostics in Europe has to date not been critically examined. The proposed fellowship, RaceCareEurope, will be the first comparative multi-country investigation of the recent introduction and use of race based health diagnostics in general practice (GP) in three different European countries (France, Belgium and the Netherlands), and the effects and consequences of using such race-based diagnostics in Europe. Ultimately, the aim of the proposed research project is to understand the knowledge sources and scientific considerations by which race-based health technologies are coming to be included in Europe, how such race-based diagnostics are used in daily general practice, and what the individual and societal consequences of this use are. The insights generated with the proposed project will provide for a much needed foundation to critically reflect on the contemporary use of the construct of race in care and medicine in Europe.

Keywords: race based care,science and technology studies,postcolonial science studies,health inequalities
Towards a unified mechanistic model of oceanic island biogeography (UNISLAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-16
End date: 2020-09-15
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

Understanding how ecological and evolutionary processes shape patterns of biodiversity remains a central challenge for ecological and biogeographic theory. Oceanic islands, because of their spatiotemporal properties, provide the most promising arena to address this challenge. UNISLAND will advance general theory by applying novel ecological, evolutionary and genomics approaches to explicitly test mechanistic predictions derived from the recently developed General Dynamic Model (GDM). The GDM, while an island focused model, is of broad ecological relevance, because it encompasses generally held ecological relationships, such as the species area relationship (SAR) and the species abundance distribution (SAD). Two key mechanistic predictions derived from the GDM have so far been untested, and are the focus of UNISLAND. The first is that the older an island is, the more old are the single island endemic species (SIEs) that evolved on that island. The second is that single island endemic species (SIEs) have higher extinction probabilities that other species. UNISLAND is embedded in a multidisciplinary framework involving: comparative phylogenetics; community-level modeling; ‘museum’ genomics; and spatially-explicit coalescent-based analysis. Data generated by UNISLAND will evaluate the range shift and extinction risk (species-level and ecosystem-level), thus addressing international and European-level research priorities. Through the collaborative phase between the ER and OPS, UNISLAND will provide the ER with state of the art skills in historical DNA genomics and ecological modelling that will be transferred to the CSIC during the return phase. The complementary research profiles of the OPS, RPS and ER, their mutual interests in the spatial structuring of biodiversity, and the application of modern fit for purpose methodology, underpin the strength of UNISLAND.

Keywords: angiosperms,arthropods,canary islands,extinction,general dynamic model,global change,hawaii,historical demography,islands,oceanic island biogeography,single island endemic species
Sustainable Consumer engagement and demand response (SENDER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Austria,Austria,Austria,Italy,Spain,Spain,Norway,Finland,Norway,Greece,Greece,France
Call: Consumer engagement and demand response (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 6619688.73
EU funding (EUR): 5836574.96
Participants: 17
Project status: SIGNED

SENDER will develop the next generation of energy service applications for demand-response, home-automation, -convenience and -security. It puts consumers at the heart of the energy market by engaging them in a co-creation process with other actors from the energy domain during the specification of pro-active DR mechanisms to cater for the consumers’ long-term incentivization. Grid operators are the 2nd group of SENDER core beneficiaries. The project results will increase the efficiency/hosting capacity of distribution networks by improving the quality of load forecasts and providing access to load flexibility, which will allow to improve frequency stability, congestion management and increased RES integration. In addition, monetarization on the flexibility potential will be provided by the participation in balancing/regulatory power markets. SENDER shifts DR from a reactive to a pro-active approach. Consumer data will be collected and processed by means of sensor data from its premises in a cyber-secure way to identify typical consumption patterns, mirror them by digital twins (DT) based on artificial intelligence technologies and aggregate the DTs supply/demand characteristics. The clustering of the consumer DTs will be conducted based on societal science approaches at three demonstration sites. Allowing interoperability with legacy systems and third-party applications, SENDER envisions business models (BM) that base on the condition that the consumer receives a fair share of the DSOs profit from flexibility use. BMs will focus on the role of the DSO as a facilitator, but also on energy communities/cooperatives as local actors that will manage their members´ flexibility assets. Based on the co-creation process, consumers will also be actively involved into the BM design. The SENDER wider roll-out after the project will be prepared by exploitation plans and implementation guides for the co-creation process and the SENDER soft- and hardware.
Catalytic foldamers from dynamic combinatorial libraries using high-throughput methods (CF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Enzymes perform essential reactions that sustain life with un-matched specificity and selectivity. Foldamers provide an opportunity to mimic Nature’s best catalysts as they are conformationally ordered structures that resemble proteins or enzymes. However, costly and time-consuming synthetic efforts have yielded only a small set of foldamers that exhibit poor catalytic activity in water. Here, we propose to combine for the first time Dynamic Combinatorial Chemistry (expertise of the host) and high-throughput screening methods (expertise of the ER) to identify a catalytically active foldamer that operates fully in aqueous solutions. The catalytic foldamer will emerge, with little synthetic effort, from a Dynamic Combinatorial Library (DCL) which contains building blocks that display key catalytic centers. The emerging foldamers will be tested for catalytic activity (e.g. hydrazone formation, ester hydrolysis) using newly-developed UPLC/UV-vis/fluorescence high-throughput protocols. This will allow rapid screening across a large substrate scope and range of experimental conditions, leading to the identification of foldamers that exhibit weak catalytic function. The activity of these hit foldamers will be optimized by combining different building blocks with optimized structures. Screening will be done in an iterative fashion to quickly survey the possible foldamer structural landscape generated from a mixture of two (or more) building blocks. The resulting data will allow essential design rules to be formulated regarding the relationship between building block structure/library components and catalytic activity. The three-dimensional structure of the discovered catalytic foldamers will be confirmed by X-ray crystallography (expertise of the secondment host).

Keywords: foldamer chemistry,dynamic combinatorial library,systems chemistry,high throughput screening,analytical chemistry,organocatalysts,click chemistry
YOurDigitalAgent: First fully automated tool for the optimisation of digital advertising for drastically increasing SMEs competitiveness and online promotion (YODA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Internet advertising is a fast growing market that in 2014 generated €120bn and it is expected that it will grow to €213bn in 2020. Its efficiency is attracting investments from traditional marketing channels as well as many new entrants, mostly SMEs, that see in online marketing an efficient tool to promote their businesses. Nonetheless, there are challenges to be overcome that are particularly relevant to new entrants, such as increasing complexity, fraudulent traffic, multi-channel possibilities and other aspects that make extremely complex to optimise online marketing strategies without the specialised support from advertising agencies. JOT intends to bring to the market the first low cost solution (multi-device, cross-channel, multi-language and cross-border) for automating the optimisation of online advertisement investments of SMEs. The virtual Advertisement Agent YODA will integrate automatic bidding and optimisation modules based on a big data analytics module that permanently monitors and analysis traffic data. Our ambition is to become the preferred advertising tool for SMEs not requiring any knowledge on online marketing. Some of the main benefits that YODA will offer are: Time reduction up to 90%, Increase of 70% in ROI (conversion rate), 25% increased efficiency due to fraudulent traffic filters and reduction of intermediary fees. According to our estimations, by 2022, 5 years after commercial launch, total revenues generated by YODA will reach 50M€ and more than 8M€ in EBITDA. JOT is one of the three largest worldwide players in internet traffic brokerage and currently manages campaigns in 61 countries and 17 languages, generating a turnover of over €39 million in 2014. Therefore, the business opportunity for JOT is crystal-clear since we are in an excellent position (technical knowledge, company size, international presence and market positioning) to successfully bring to the market, commercialise and exploit the above mentioned solution.

Keywords: online advertisement,automatic optimisation,traffic data,big data,automatic bidding,moment of truth