Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Control, Process and Green Solvent Design for Biorefinery Process (GreenSolProCon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 2
Project status: SIGNED

This project proposes a comprehensive approach to design future biorefinery and biobased chemical plants by integrating green solvent, process, and control design. Green solvents, such as Ionic Liquids (ILs), Deep Eutectic Solvents (DESs), and biobased solvents, offer a sustainable alternative to conventional toxic solvents. Despite their potential, their application in chemical process plant design remains underexplored. This project aims to develop a holistic framework that addresses the unique properties of green solvents, focusing on mathematical modeling, solvent regeneration design, dynamic process analysis, control system design, and experimental validation. By advancing green chemistry practices, the project aspires to pave the way for sustainable, commercial-scale biorefinery plants, aligning with the goals of a circular economy and contributing to a green transformation of the chemical industry. The project will model solvent properties, optimize process efficiency, and ensure safe and sustainable chemical processes, ultimately setting a new standard for the biobased industry.

Keywords: green solvents,integrated design,solvent regeneration,biobased economy,green chemistry,sustainability
SMART ENERGY HARVESTING AND TRANSMISSION FOR A RELIABLE EUROPEAN ELECTRICITY GRID BASED ON DYNAMIC LINE RATING (DLR) MODEL FOR HIGH TEMPERATURE LOW-SAG (HTLS) POWERLINES (HEROGRID)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,Denmark,Germany
Call: Emerging energy technologies for a climate neutral Europe (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 2494207.25
EU funding (EUR): 2494206.25
Participants: 6
Project status: SIGNED

To meet the European Green Deal transformation for the European power sector, electricity demand is expected to jump from 20% to nearly 50%. Distributed and intermittent energy renewable resources has introduced bidirectional and complex power flows, leading to numerous bottlenecks and stability challenges. To address these challenges, the EU’s Energy Digitalization Action Plan outlines the need for substantial investments focused on the distribution grid. October 2023 saw the introduction of the EU Action Plan for Grids, which emphasizes the optimization and smarter utilization of existing grid infrastructures. A key innovation is Dynamic Line Rating (DLR) systems, which use IoT networks on power lines to make real-time adjustments, maximizing capacity and reducing congestion. However, these systems have mainly been used in traditional grids and haven't fully integrated innovative approaches like High-Temperature Low-Sag (HTLS) conductors, operating at higher temperatures with minimal sag, offer up to 33% enhanced transmission capacities and are increasingly seen as replacements for traditional conductors. Nonetheless, the integration of HTLS technologies with advanced DLR systems. HEROGRID aims to bridge with new AI-based DLR models specifically designed for HTLS powerlines. Additionally, the project seeks to pioneer IoT devices that are not only compatible with HTLS environments but are also self-powered through innovative energy harvesting technologies including piezoelectric and thermoelectric systems combined with efficient power management system. HEROGRID enhances operational efficiency and cuts maintenance costs for renewable energy infrastructures. By integrating advanced technologies into the European power grid, it supports the EU's transition to sustainable energy, enabling new business models for grid operators. Aligned with Horizon-Cl5-2024-D2-01-04, HEROGRID promises substantial contributions to energy distribution and transmission.

Keywords: dynamic line rating iot smart grid high temperature log sag powerlines artificial intelligence energy harvesting
Harmonisation and monitoring platform for certification schemes and labels to advance the sustainability of bio-based systems (HARMONITOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Netherlands,Germany,Italy,Denmark,Austria,Estonia
Call: International and EU sustainability certification schemes for bio-based systems (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 11
Project status: CLOSED

The HARMONITOR project will improve the effectiveness of certification schemes and labels (CSLs) in different sectors of the EU Bioeconomy and therewith strengthen their use as a co-regulation instrument. Effective and robust CSLs can cope with some of the difficulties that public regulation faces and fill in policy gaps. The HARMONITOR project will also establish and test a participative review platform concept that allows CSLs to find commonalities and cooperation when operating in bio-based value chains within and across EU borders. This platform is based on the innovative ‘Sustainability Certification Tools’ proposed by the Horizon 2020 project STAR-ProBio to promote continuous improvement of CSLs and continuous knowledge of these dynamic developments by market actors. The specific objectives of the HARMONITOR project are: 1. To establish a review platform to capture the dynamic development of CSLs and encourage their harmonisation and continuous improvement through the exchange of information and promotion of best practices. 2. To provide quantitative, transparent data on bio-based value chains through analysis and dissemination of trade flows (certified and non-certified), and quantification of direct and indirect costs and benefits of certification. 3. To review and compare performance requirements and assurance and governance systems of CSLs. 4. To develop and apply a monitoring system on the effectiveness and robustness of CSLs. 5. To improve the understanding of the opportunities and limitations of using CSLs in co-regulation. The HARMONITOR approach aims to achieve the following outcomes: • Enhanced transparency and traceability of environmental impacts along value chains through improved CSLs. • Higher levels of effectiveness and robustness of CSLs through systematic monitoring. • Increased awareness of trade flows and their impacts. • Possible use of CSLs as a co-regulation instrument as part of the EU Bioeconomy policy framework.
The origin of living wild equids (zebras and asses): Fossils and molecules fill the gap in the evolutionary history of the genus Equus. (STRIPES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

The evolutionary history of the genus Equus is a paradigmatic case of adaptation to different environments through time. Modern equids may be divided in two large groups based on genomic and morphologic evidence: the caballine horses (Przewalski’s and domesticated horses) and the stenonian wild equids (zebras and asses). Although molecular studies have clarified the evolutionary history of the caballine horses, the origin and evolution of the wild zebras and asses remains enigmatic, despite their well deciphered genomes. STRIPES aims to resolve the phylogeny of the genus Equus, with emphasis on extant zebras as well as African and Asian asses. To do so, I plan to study the fossil horses collections housed at the ICP (Sabadell, Spain), of the the MNHN (Paris, France) and of the NHMUK (London, England). These institutions have important collections from key sites in Eurasia and Africa, with ages matching with the estimated divergence time interval between zebras and asses at ca. 1.8 Ma. I will use 2D and 3D geometric morphometric approaches to more accurately characterize the anatomy of the fossil and living Equus species, and I will further integrate morphological information with genomic (paleoproteomic and molecular) data to perform the first Bayesian total evidence (tip dating) phylogenetic analysis of the genus Equus, which will enable to refine the branching topology and estimated divergence dates of its main lineages. The combination of paleontological and neontologial data, both morphological and molecular, represents a transverse approach of this study between Paleontology, Zoology, and Molecular Biology. The results of this project will yield the most complete phylogeny of the genus Equus thus far, pushing forward the current state-of-the-art and clarifying the evolution and origin of the living zebras and asses. Moreover, this project will also provide important information for the Conservation (Paleo)biology of these threatened and endangered wild animals.

Keywords: vertebrate paleontology paleoproteomics equids geometric morphometrics phylogeny
Connected, Cooperative and Automated MoBility Assessment & Stakeholder Dedicated and Operational awareness Raising (CCAMbassador)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Coordination and support actions
Partnership: CCAM (co-programmed)
Countries involved: Belgium,Austria,Netherlands,Greece,Spain,Norway,Czechia,Croatia,Germany,France,Sweden,Finland,Switzerland
Call: Robust Knowledge and Know-How transfer for Key-Deployment Pathways and implementation of the EU-CEM (CCAM Partnership) (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 4937051.73
EU funding (EUR): 4499846.19
Participants: 22
Project status: SIGNED

CCAMbassador complements the coordination and alignment efforts of the CCAM Partnership by expanding stakeholder engagement beyond research, innovation and experts’ communities. CCAMbassador aims at supporting stakeholders to move into operations by identifying key building blocks for deploying services, strengthening cooperation between all CCAM stakeholders, specifically between the EU Member States/Associated countries, ensure the wide use of the EU-CEM, as well as to expand the existing EU-wide Knowledge Base on CCAM and further adapt it to the needs of targeted stakeholder groups, namely implementers and citizens.

Keywords: ccam,coordination,cooperation,concertation,exchange,knowledge base,lessons learnt,harmonisation,methodology,implementer,citizen,research,innovation,deployment
Delivery of three new antibiotics to the market to address World Health Organisation's 5 areas of greatest need. (Helperby Antibiotics)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 7500000.0
EU funding (EUR): 7500000.0
Participants: 1
Project status: CLOSED

-Anti Microbial Resistance (AMR) is reducing the effectiveness of most established antibiotics, leading to rapidly escalating deaths and hospitalisations; -New Chemical entities are costly (c€600m) and take 10+ years to develop; -Helperby was spun out of St George's Hospital and the University of London to address the AMR crisis. -Helperby has a programme to deliver three new antibiotics to the market for c€25m each and within 3-5years each; -All antibiotics are novel combinations of existing approved antimicrobial drugs, greatly reducing cost and increasing the chance of regulatory approval; -Within 10 years of securing €80m we can create revenues of €2.6BN with profits of €1.8BN, all at globally affordable prices; -This process will create a platform for the discovery and development of an extensive range of new antimicrobial combinations, providing sustainable solutions to the growing problem of Antimicrobial Resistance (AMR); -These products will save lives and will create a platform that will resolve the AMR crisis in the long term.

Keywords: novel combinations of existing antibiotics at 5 of the cost and half the time of new chemical entities
Splicing Fidelity: Enforcement, Modulation and Impairment. (SPLIFEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499513.0
EU funding (EUR): 1499513.0
Participants: 2
Project status: SIGNED

In eukaryotes, the spliceosome removes non-coding introns from precursor messenger RNAs during pre-mRNA splicing. Crucially, many pre-mRNAs are spliced differently depending on cellular status or external stimuli. This “alternative splicing” reshapes the genetic information from a given mRNA to encode several protein isoforms and greatly diversifies proteomes. Splicing must be extremely precise as errors produce aberrant mRNA encoding potentially toxic proteins. Splicing fidelity relies on the accuracy of the spliceosome that assembles de novo on each pre-mRNA in a cotranscriptional manner, gets activated and selects the precise boundaries of introns to catalyse their excision. The spliceosome is endowed with two apparently conflicting properties: it must be very accurate to avoid splicing errors while being tolerant to accommodate alternative splicing changes. I. aim to unveil the molecular basis of splicing fidelity’s enforcement and modulation by the spliceosome. Due to its extreme complexity, the spliceosome has long been a major challenge for molecular and structural investigations. Recent progresses in cryo-EM allow the structural analysis of very dynamic and low-abundance biological objects such as spliceosomes. Hence, it is now possible to explore the most elusive aspects of RNA splicing, provided that the biochemical challenges of trapping and stabilising transient spliceosome intermediates are overcome beforehand. I will use innovative methods to capture spliceosomes from cell extracts and cryo-EM to investigate how splicing fidelity is: • enforced by molecular checkpoints during spliceosome activation • maintained/modulated by other cellular processes • impaired during viral infection The outcome of this research will bring us closer to answering a fundamental question of biology: how does the spliceosome give rise to the immense combinatorial space of alternative splicing without errors and allow the 20,000 human genes to yield 200,000 proteins.

Keywords: spliceosome cryo em splicing fidelity ribonucleoprotein remodelling
Integrative science, Intelligent data platform for Individualized LUNG cancer care with Immunotherapy (I3LUNG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Italy,Switzerland,Israel,Belgium,Sweden,United States,Denmark,Germany,Spain,Greece
Call: Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 9996697.5
EU funding (EUR): 9996695.0
Participants: 16
Project status: SIGNED

Immunotherapy (IO) is the new standard of care for many patients with advanced Non-Small Cell Lung Cancer (aNSCLC), yet only around 30-50% of treated patients benefit from IO in the long term. Programmed Death-Ligand 1 (PD-L1) remains the only biomarker used to predict patient outcome to IO, though its efficacy is limited. Other potential biomarkers have been identified, yet not validated in prospective randomized clinical trials, providing only partial evidence. Due to the dynamic complexity of the immune system-tumour microenvironment, its interaction with the host and patient behaviour, it?s unlikely for a single biomarker to accurately predict patient outcome. Artificial Intelligence (AI) and machine learning (ML) frameworks, that synthetize and correlate information from multiple sources, are essential to develop powerful decision-making tools able to deal with this highly complex context and provide individualized predictions to improve patient outcomes reducing the economic burden of health care systems in NSCLC. The aim of the I3LUNG project is to develop such AI-based tools to assist in improving survival and quality of life, preventing undue toxicity, and reducing treatment costs. I3LUNG adopts a two-pronged approach: setting up a transnational platform of available data from 2000 patients in order to validate the AI models, and generating a multi-omics prospective data collection in 200 NSCLC patients integrating diverse -omic information then validate its usefulness in leading IO therapeutic decisions. A psychological study will help in defining the impact of AI-guided decisions on patients, eliciting their preference, and physicians comparing AI with Human Intuition. The final goal is the construction of a novel integrated AI-assisted Data Storage and Elaboration Platform backed up by Trustworthy Explainable AI methodology, ensuring its accessibility and ease of use by healthcare providers and patients alike.

Keywords: lung cancer,nsclc,immunotherapy,artificial intelligence,machine learning,predictive model,prognostic,tool,radiomics,multi omics,biomarkers,co decision making,e health,medical informatics
The sympatric lifestyle of giant viruses: contact tracing and fitness through mobile genetic elements (CHIMERA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1499899.0
EU funding (EUR): 1499899.0
Participants: 1
Project status: SIGNED

Giant viruses appear to be ubiquitous in soil and aquatic environments, infecting a wide range of protist hosts. As lytic viruses, they are important regulators in nutrient and energy cycles and key influencers of microbial community composition. The recent discovery of giant viruses challenged previous assumptions and blurred the sharp division between viruses and cellular life. Besides large particle sizes, giant viruses possess complex "chimeric" genomes, including genes that were likely acquired from their hosts and bacteria that parasitise the same hosts. Unique is the presence of prokaryotic-like mobile genetic elements (MGEs) that are speculated to aid giant viruses in defence against the host immune system or in direct competition for resources with other viruses or bacteria. Contrarily, bacteria may use MGEs to help the hosts counteract viral infections. Our current knowledge on the factors promoting giant virus diversity and maintenance of the virus-host balance in nature, are largely unknown. In the proposed project, I will investigate the role of MGEs in the evolution and ecology of giant viruses. I postulate that the presence of MGEs plays a crucial role in the competition between giant viruses and other parasites infecting the same hosts. Using co-infection experiments, as well as cutting-edge molecular, microscopy, and sequencing techniques, I will investigate viral competitive fitness as well as physical and molecular interactions between selected partners. By developing a highly specific giant virus genome editing tool, I will rigorously test whether MGEs can provide giant viruses with higher fitness. Moreover, I will combine cell sorting with metagenome analysis of two selected habitats, to unravel how MGEs are distributed in a natural ecosystem. My overarching goal is to elucidate the molecular dialogue between viruses, bacteria, and their hosts, and to use MGEs as a tool to trace the evolutionary history of this unique group of viruses.

Keywords: virus evolution,giant viruses,virus interactions,mobile genetic elements,fitness competition and defence