Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Melanoma Early Warning System (MERWIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

However, there are several tools and solutions for aiding the melanoma detection (variable dermatoscopes, full-body mapping tools and Applications), they were not able to achieve breakthrough in the early diagnosis phase. It comes from the wrong methodologies. There are two types of available tools: 1) diagnostic tools, whit the aim of diagnosing skin-cancer without human intervention, and 2) medical equipment, which help the work of dermatologist during the examination in a doctor’s office. The problem with first methodology (artificial based skin-cancer diagnosis) is that these do not work reliable or do not work at all. The main problem of the second methodology is the very rare examination frequency. An average health conscious European adult visits skin-cancer screening in every 3-7 years. In contrast with these, MERWIS offers a solution that focuses on increasing the examination frequency, where the system does not need to establish a full diagnosis. MERWIS only looks for evolution (change) of every single monitored mole, but with high or very high frequency. The validated and demonstrated MERWIS prototype is based on the fact that most clinical signs of melanoma are all visible. Through using the combination of a special body-mapping cabin, a mobile application based “self dermoscopy”, and a computer assisted qualitative data analysis software we can detect all the visible changes of melanoma ABCDE. Furthermore our system uses a custom made distributed ledger technology-based network cloud solution. Based on this framework it is possible to build the MERWIS decentralized database on a maximum security level and ensure scalability. The aim of this Phase 1 project is to carry out an extended feasibility study consisting of market assessment, business model validation, risk and IP strategy assessment, up-date and advancement of the business plan, and international pilot location selection to support the global commercialisation of our technology.

Keywords: early cancer detection,melanoma,image analysis,decentralized network,new prevention protocol
Supporting deep-tech based innovative market players to uptake opportunities, upgrade performance and upscale their business (STARTUP3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Greece,Slovenia,Serbia,Latvia,France,France
Call: Startup Europe for Growth and Innovation Radar (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 1555921.16
EU funding (EUR): 1283644.81
Participants: 7
Project status: CLOSED

For the EU deep-tech startup scene to grow sustainably and achieve its potential impact, access to real market problems and test beds is required. Driven by real market needs, or as STARTUP3 defines it, Key Performance Areas, the project builds and facilitates an open and collaborative ecosystem for high impact deep-tech innovators and corporates and acts as a cross-border/sectoral market-maker. The project aims to generate, take up, ensure market penetration and further capitalize on the growth and impact potential of profound research by providing access to dynamic and 3-phase across the board growth support framework UPTAKE-UPGRADE-UPSCALE. The catalysation is aimed at creating synergies across the Europe, networking, raising understanding of the benefits of deep-tech technology and stimulating their uptake - Cluster Missions and Clusters-Corporate Assembly. The STARTU3 consortium is a fusion between geographically scattered Clusters (POLE SCS, LITC, ITC) international innovation and Tech-transfer specialists (INO and EKT), SME focused on upscaling research and technology (AGENSO), startup studio (HOLA-UP).

Keywords: open innovation,startup europe,innovation radar,deep tech
Growth balance regulation by SnRK1 under ABA-stress conditions (ABA-GrowthBalance)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-10-01
End date: 2021-11-04
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

In response to adverse environmental conditions, such as water scarcity, extreme temperatures or salinity plants trigger responses that promote stress tolerance and survival at the expense of growth. Despite the negative impact of stress on crop productivity how growth is modified by stress signalling pathways is largely unknown. One major component of the response to the most devastating stresses is ABA, a hormone that triggers cellular and whole-plant adaptive mechanisms via the activation of SnRK2 protein kinases. Another major player is the energy sensing SnRK1 protein kinase, which promotes plant stress tolerance and survival through the vast regulation of metabolism and gene expression. Preliminary results in the host lab have revealed deficient ABA responses in a partial SnRK1 loss-of-function mutant as well as the physical interaction between SnRK1 and the ABA-activated SnRK2 kinases, suggesting a functional connection between these two pathways. Furthermore, SnRK1 and SnRK2 have recently been implicated in the repression of a central growth regulator, the TOR (Target of Rapamycin) protein kinase. The aim of this proposal is to investigate the interaction between these two major stress-related kinases (SnRK1 and SnRK2) and to elucidate the mechanism(s) by which they modulate growth-promoting signalling pathways in response to ABA. To tackle the functional relevance of the SnRK1-SnRK2 connection, a combination of biochemical approaches, genetics, microscopy, cell-based assays and chemical genomics will be used. To identify growth regulators downstream of the SnRK axis, targeted analyses of TOR readouts will be employed in combination with unbiased analyses of SnRK1 interactors and substrates in ABA. Altogether this project will provide novel molecular insight on the trade-offs between stress tolerance and growth/yield that may potentially contribute to more successful crop improvement.

Keywords: abiotic stress,sugar signaling,snrk1,abscisic acid aba,snrk2,growth balance,target of rapamycin tor
Scattering-Based X-ray Imaging and Tomography (S-BaXIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2212913.75
EU funding (EUR): 1600413.75
Participants: 2
Project status: SIGNED

This research project will create new ways of doing X-ray imaging based on scattering and data redundancy. Many X-ray imaging techniques are based on simple models that fail to capture important phenomena, such as small-angle or incoherent scattering. Far from being a nuisance, scattering signals often hold valuable information on the finest structure of the investigated sample. For instance X-ray scattering can reveal fibre orientations in a carbon-fibre composite or the early formation of cancerous tissues in mammography. To exploit scattering, adapting data acquisition is often necessary. Collecting diverse but partly redundant datasets is a powerful way to encode information so that it can be subsequently decoded with appropriate software. For this purpose one can, for instance, displace the sample in a non-uniform illumination profile. Another often overlooked source of redundancy is tomography itself, where projection images from different view angles are strongly correlated. The central achievements of this research project will be the introduction of a new formalism that offers a complete picture of scattering in the context of imaging, and the development of techniques that exploit explicitly measurement diversity - in particular tomographic redundancy - to extract complementary information. These new paradigms will be implemented and demonstrated with a range of X-ray imaging techniques: ptychography for high-resolution imaging, speckle-based imaging for lab-based phase-contrast and dark-field, and conventional transmission microCT, for scattering signal extraction. The expected results of this research project will leave a lasting impact on the research community. The full exploitation of data redundancy and scattering-aware models will create imaging modalities that can reveal features that could not be seen before for a broad range of applications, from advanced materials to fragile biological samples, to valuable heritage and archaeological artefacts.

Keywords: x ray imaging,x ray nano computed tomography,scattering,ptychography,reconstruction algorithms,diffraction
How our expectations can make us hallucinate: the neural mechanisms underlying perception (EXPECTPERCEPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1484575.0
EU funding (EUR): 1484575.0
Participants: 1
Project status: SIGNED

The way we perceive the world is strongly influenced by our expectations about what we are likely to see at any given moment. In certain situations – namely when sensory signals are very weak or noisy and expectations are very strong – expectations can even induce hallucinations: seeing an expected stimulus despite its absence. However, the neural mechanisms by which the brain integrates sensory inputs and expectations, and thereby generates the contents of perception, have yet to be established. Previous work, including my own, has demonstrated that processing in the visual cortex is strongly modulated by prior expectations. However, perhaps surprisingly, previous studies have not yet explained how these modulations relate to subjective perception, leading to a lacuna in our knowledge of how the brain supports perception. Here, I propose to study the neural mechanisms underlying subjective perception by using strong visual expectations to induce hallucinations in healthy human participants. I hypothesise that, upon presentation of a predictive cue (e.g., a siren), memory systems pre-activate templates of expected stimuli (an ambulance) in the deep layers of visual cortex, leading to biased processing of sensory inputs from the very moment they arrive. I will test this proposal by addressing three complimentary questions: 1) How do expectations filter perception? 2) What is the computational architecture underlying perceptual inference? 3) What is the neural source of expectations? I will combine psychophysical tasks probing participants’ perception with neuroimaging tools with exquisite spatial (high-field fMRI) and temporal (MEG) resolution to address these questions. The overarching aim of my research is to provide a mechanistic account of subjective perception. Ultimately, these insights may improve our understanding of clinical disorders characterised by aberrations in perception, such as psychosis.

Keywords: neuroimaging,perception,prediction,predictive coding,memory,expectation
Friends or foes? The role of Biofilm microbiomes in industrial anaerobic membrane bioreactors to MAXimise bioenergy production (BioMAX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Transforming the European Union into a competitive low-carbon economy by 2050 requires the industry sector to continue implementing energy-efficient processes, especially for the valorisation of biodegradable waste and wastewater. Anaerobic digestion membrane bioreactors (AnMBR) is an emerging technology combining the production of methane-rich bioenergy and high-quality effluents free of particles, colloids and pathogens. However, the presence of biocidal or inhibitory compounds found in many industrial wastewaters hinders the implementation of AnMBR associated to low process efficiencies and instability. Additionally, the adhesion of particles and formation microbial biofilms into the membrane surface results in increased operational energy requirements. Biofilm formation may be exacerbated when treating industrial wastewaters containing high concentrations of inhibitory compounds since biofilm formation is a widespread microbial survival strategy to thrive under unfavourable conditions. However, are biofilms friend or foe? A controlled biofilm formation may be beneficial to improve AnMBR robustness and methane yields since the protection given by the biofilm structure allows microorganisms to function in harsher conditions. Understanding the interaction between biofilm formation and functionality in anaerobic biotechnologies is key for the success of AnMBR technology and the valorisation of heavily polluted industrial wastewaters. To this aim, I will systematically study the identity, dynamics and ecophysiology of planktonic and biofilm microbiomes occurring in AnMBR treating pharmaceutical wastewater. Harnessing this knowledge will allow the quantification of the role and potential of microbial biofilms to improve AnMBR performance, robustness and economic feasibility. The experience gained from combining microbial and engineering approaches will lay the foundations to develop and improve biofilm management strategies for a successful AnMBR implementation.

Keywords: wastewater,microbial ecophysiology,anaerobic digestion
Resilience Strategies for Regions (REGILIENCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: Germany,Austria,Ireland,Germany,Belgium,Croatia,Netherlands,Netherlands,Portugal,United Kingdom
Call: Climate-resilient Innovation Packages for EU regions (H2020-LC-GD-2020-2, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 2994472.5
EU funding (EUR): 2994472.5
Participants: 10
Project status: SIGNED

REGILIENCE aims to foster the adoption and wide dissemination of regional climate resilience pathways, following a demand-driven approach and bearing in mind the expertise and knowledge acquired, as well as the solutions available from Innovation Packages and other sources. It will implement the LC-GD-1-3-2020 RIA project results on the Innovation Packages. REGILIENCE will provide coordination by developing a needs survey covering the 50 most vulnerable regions in the EU, which will be shared and matched with Innovation Package projects, 2 citizen surveys and the development of an indicator set for regional resilience, including its testing. We will furthermore review and foster synergies of 30 online platforms to improve their performance and usability for regions and communities. In terms of support, REGILIENCE will provide wide dissemination of the solutions and approaches within networks, regional authorities and key stakeholders, including civil society organisations and citizens. Overall, we plan for almost 700 specific activities with an estimated audience of 100,000 individuals, including 8 large network events, 52 workshops/webinars, 30 twinning, 300 helpdesk, 10 testing, and 40 media activities, amongst others. These aim to share experiences, learn from failure, provide guidance and disseminate knowledge and tools which will be developed by REGILIENCE, such as the Resilience Fundamentals Course, a citizen Resilience Scan Tool, information about resilience funding and financing, including recommendations for the inclusion of climate resilience in the national and regional plans for the EU Recovery Package and the Multiannual Finance Framework, on overcoming barriers and obstacles, maladaptation and the running of 10 tests for innovative public-private partnership approaches. Complementary to wide dissemination, we plan to facilitate the replication of Innovation Packages in 10 additional vulnerable and low-capacity regions.

Keywords: resilience strategies,climate adaptation,innovation packages
Establishing SME Innovation Management Services in the Austrian Enterprise Europe Network (SMEINNOAUSTRIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Austria,Austria,Austria,Austria,Austria,Austria
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 113007.5
EU funding (EUR): 90406.0
Participants: 9
Project status: CLOSED

The Horizon 2020 work programme names the lack of innovation management capacity as “…an important barrier to creating economic impact…” and accordingly as a significant challenge for innovative SMEs. The problem is exacerbated by the fact that consulting services to address these gaps are either not sufficiently available in certain regions, not affordable or not sufficiently tailored to the specific needs of SMEs. In the course of this action, the Austrian consortium will support SMEs in addressing these factors hindering successful innovation cycles. Activities will be targeted at enhancing the innovation management capacity (EIMC) of SMEs and at providing substantial consulting and support services in the form of key account management (KAM) to beneficiaries of the Horizon 2020 SME instrument. The support will be delivered by experts well experienced in innovation related issues, working for the major innovation and research promotion agencies in Austria. Services will be provided in close cooperation and coordination with the National Contact Points and major regional and national stakeholders, guaranteeing a holistic approach and a high quality of services promoting the successful introduction of Austrian innovations to the European and international market.

Keywords: innovation services,key account management,enhancing the innovation capacities of smes
Optimodal European Travel Ecosystem (EuTravel)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Italy,Spain,Germany,Cyprus,Belgium,Greece,Belgium,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Towards seamless mobility addressing fragmentation in ITS deployment in Europe (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2017-10-31
Duration (months): 30.0
Total project cost (EUR): 3873992.5
EU funding (EUR): 3873992.5
Participants: 19
Project status: CLOSED

EuTravel aims to: 1. Support the EU agenda towards an open and single market for mobility services by enabling travellers to organise a multimodal trip in accordance with their own criteria including environmental performance, providing multimodal travel service providers an effective way to deliver customised services addressing any type of specialised travel needs and facilitating fact-based EU policy making. 2. Promote the creation of content, open and linked data for travellers enriching the travelling experience. 3. Support travel industry players join forces towards realising an EU shared seamless mobility strategy and architecture. EuTravel will research and demonstrate Inter-modal travel optimised with respect to synchronisation between modes, passenger experience and rights and environmental performance (Optimodal Travel). The project objectives will be realised by: 1. Developing an open and readily usable Optimodality Framework aimed at integrating processes, data, and systems in a manner that eliminates interoperability barriers to the marketplace emergence of truly Optimodal travel services: from planning through booking and the full range of related travel support solutions. 2. Delivering Optimodality Ecosystem Enablers, offering an open infrastructure that allows organisations to set up cost-effective integration of existing systems and to create value added multimodal travel services. 3. Organising and developing a Living Lab to experiment and evaluate new concepts and prototype solutions in real life multimodal travel scenarios and obtain data to quantify impact. 4. Taking actions towards sustainable development including a Stakeholder Engagement Strategy and wide dissemination. EuTravel, unlike other projects/initiatives, will deliver an Ecosystem promoting and supporting Optimodal travel that will have higher chances of success as it will be populated with tools that tap into existing mainstream IT travel reservation systems and sources of data.

Keywords: optimodal travel,mobility,intermodal travelling,multimodal journey,ecosystem,interoperability standards,door to door trip