Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploring Natural Immunity in Retinal Neovascular Disease (NK InSight)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1999681.0
EU funding (EUR): 1999681.0
Participants: 1
Project status: SIGNED

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the world. The number of people with AMD has reached 196 million, with ~1 in 10 people over 55 years already showing early signs of the condition. 70% of those who progress to late-stage disease will develop neovascular (nv)AMD due to uncontrolled growth of blood vessels behind the retina. In fact, aberrant growth of retinal or choroidal vasculature is a hallmark of diabetic retinopathy and nvAMD. Collectively, these are the most common causes of central vision loss globally. Identification of new biological processes that regulate neovascularization are urgently needed to open new therapeutic options for patients. This is a challenge; but with recent longitudinal studies showing unequivocally that current gold-standard care has a therapeutic ceiling, it presents a critical unmet clinical need. I have recently discovered that natural killer cells (NKs) are found in neovascular lesions in human AMD and our mouse model data suggests that these innate lymphoid cells (ILCs) play a role in inhibiting pathology. Using scRNAsequencing I discovered a defined subset of NKs in neovascular lesions in a model of resolving nvAMD. I now hypothesize that, in contrast to expectations, these ILCs play a critical role in remodelling neovascular lesions, limiting pathology as opposed to exacerbating it. NK cells are completely unstudied in the retina. Here, I propose that manipulating NK cells may represent a novel therapeutic strategy for the prevention and treatment of neovascular eye disease. Objectives: 1) Examine NK cell function in models of retinal neovascular disease 2) Profile NK cells in AMD pathology in a human study 3) Develop microfluidic “neovascular retina-on-a-chip” model to examine NK cell mechanism-of-action 4) Determine if NK cell therapy can ameliorate neovascular eye disease Goal: To harness the power of NK cell activity to treat neovascular eye diseases

Keywords: natural killer cell,retinal neovascular disease,age related macular degeneration amd
enhanced manufacturing of broadly potent equine polyclonal Fab with a Rational Immunization strategy against Coronaviruses (e-FabRIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Belgium,Spain,United Kingdom
Call: Pandemic preparedness and response: Broad spectrum anti-viral therapeutics for infectious diseases with epidemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 7666548.75
EU funding (EUR): 7666548.75
Participants: 6
Project status: SIGNED

e-FabRIC will develop a new hyperimmunization strategy for generating high titers equine immunoglobulins having a broad neutralizing specificity against viral targets belonging to same subfamily phylogenic tree. The viral subfamily selected to demonstrate the unique benefits of this innovative way to induce highly anti-viral active antibodies is the sarbecovirus subfamily. The equine antibodies will be processed as purified F(ab’)2 fragments, a well-known pharmaceutical product with a strong historical safety record in human patients. The F(ab’)2 antibody fragments generated by e-FabRIC are expected to display a unique and very wide neutralizing activity spectrum. This new property will be the synergistic outcome of the immunization with a nanoparticle co-displaying 8 different sarbecovirus RBD subunits (designated as “mosaic antigen”) and the natural immunogenetic diversity present in individual horses. In each individual horse, the mosaic antigen immunization will drive the generation and maturation of antibodies highly focused on conserved epitope structures shared by the different sarbecovirus RBD subunits and associated with viral neutralization. As each horse's own immunogenetics will mature the mosaic antigen-specific antibodies in a different way, several equine individual antibody specificities will be pooled in order to expand the overall broad viral neutralizing activity of the final pharmaceutical product. The combined multiplicity of individual antibody response diversities and the highly focused antibody responses induced by the mosaic antigen will be the basis of a broadly potent, immunotherapy pharmaceutical F(ab’)2-based product able to significantly reduce the clinical and societal impact of any emergence of a new human sarbecovirus outbreak. The scientific and technical learnings of this new and powerful immunization strategy will be applicable to other viral families from which human infectious threats may arise.

Keywords: mosaic 8 antigen,equine polyclonal antibodies,anti viral active antibodies,sarbecovirus subfamily,viral neutralization,3r qc compliance
Expanding FAIR Solutions across EOSC (FAIR-IMPACT)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Coordination and support actions
Partnership: EOSC (co-programmed)
Countries involved: Netherlands,France,Germany,Norway,Spain,Italy,Belgium,Romania,United Kingdom,Finland,Denmark
Call: Enabling discovery and interoperability of federated research objects across scientific communities (HORIZON-INFRA-2021-EOSC-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 8011446.25
EU funding (EUR): 8011443.0
Participants: 28
Project status: CLOSED

FAIR-IMPACT focuses on expanding FAIR solutions across the EOSC. It builds on the results of FAIRsFAIR and other relevant projects and initiatives. The project aims to realise a FAIR EOSC, that is an EOSC of FAIR data and services. FAIR-IMPACT will identify proven domain solutions and facilitate the interoperable uptake of these solutions across scientific domains and for different types of research output. This includes the overall FAIRification of various research objects from assigning and managing identifiers, describing them with shared and common semantics to making them interoperable and reusable, as well as the challenge of projecting the FAIR principles to other types of research objects such as software. FAIR-IMPACT meets these challenges through three work packages which identify and adapt candidate approaches, tools and solutions suitable for wider adoption, and two work packages focussing on interoperability, adoption and support. Scientific communities are included in the consortium as integrated use case partners. This will ensure that viable and tested solutions from one domain can be piloted in others and help to achieve wider uptake, adoption, implementation of, and compliance with the FAIR principles. As the project unfolds, additional support mechanisms (cascading grants, in-kind support) will be introduced. The FAIR-IMPACT ambition is to build a web of FAIR data and related services together with the scientific community and relevant stakeholder groups, and to take steps towards realising the ambition of a web of Open Science. FAIR-IMPACT will contribute to transforming the way researchers share and exploit research outputs within and across research disciplines? and to the facilitation of scientific multi-disciplinary cooperation. With its focus on increasing FAIRness, FAIR-IMPACT will contribute to improving public trust and reproducibility in science.

Keywords: fair,eosc,implementation,adoption,support,coordination,engagement,data,software,metadata,identifiers,metrics,certification,domains,interoperability,cross disciplinary,use cases
Solutions to prevent and mitigate the impacts of HABs in Aquaculture and Fisheries, in the context of global warming (BlueShellfish)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal,Sweden,Spain,China,Brazil,Chile,Italy,France,Cuba,Mozambique,Australia
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 333171.43
EU funding (EUR): 331200.0
Participants: 13
Project status: SIGNED

Harmful algal blooms (HABs) are considered a threat to the environment and to human health. Major concerns are addressed to the increasing occurrence of these natural events in certain regions of the world, driven by global warming and anthropogenic pressure. Human illnesses related to the intake of contaminated seafood have been attributed to these events. Furthermore, HABs have a significant impact in economic activities such as aquaculture and fisheries. The occurrence of HABs in natural areas utilized for aquaculture (or harvesting/fishing), can affect species growth and nutritional parameters, or even cause mass mortalities, causing huge losses in the industry. The regulation of toxin levels in seafood and other measures (e.g. forced closures to seafood harvest during the occurrence of HABs) have been contributing to protecting humans from serious intoxications. On the other hand, the impacts on the industry lack mitigation measures. This project aims to contribute to the development of solutions for the aquaculture and fisheries sector, through the development of efficient methods for the detection of HABs (early warning), and the development of farming and depuration systems for shellfish to reduce the toxin load. The project also aims to advance in the understanding of regulated and emerging toxins (chemical and toxicological evaluation) and their global expansion, and toxin incidence and persistence in seafood (traditional and non-traditional vectors, species not yet investigated). For the implementation of the project, an interdisciplinary consortium was built, which brings together specialists from different areas of knowledge and who will develop joint research and innovation activities which, collectively, will contribute to the technological innovation of the aquaculture and fisheries and sustainable growth of this sector and to environmental monitoring.

Keywords: harmful algae,marine biotoxins,environmental monitoring,early warning,seafood contamination
On-demand generation of multi-photon linear cluster state (ODeLiCs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Photonic quantum devices promise a scalable way to realize real-world applications of quantum communication and computation. An integral part of this vision comprises utilizing cluster states, i.e., a type of highly entangled multi-qubit state which provides the fault tolerance needed in almost all quantum protocols. I plan to demonstrate the first on-demand multi-photon cluster state source. Although the realization of an efficient cluster state source has been a long-standing challenge, recent improvements in quantum dot spin control and the collection efficiency in photonic crystal waveguides have made this ambitious goal feasible. I will use a recently established technique to prepare and cool the nuclear spins surrounding the quantum dot. Cooling down the nuclear spins will improve the electron spin dephasing time by 20 folds to 50 ns, which corresponds to above 99% spin rotation fidelity. To improve the photon collection efficiency, I will utilize a one-sided photonic crystal waveguide which provides a near-unity coupling to a single waveguide mode. Moreover, I will use an inverse design method to improve the chip-to-fiber coupling efficiency to above 90%. The cluster state generation will be implemented with a time-bin protocol, which entangles the quantum dot spin states with the emission time of single photons. Using realistic experimental parameters, the estimated three-photon cluster state fidelity in this protocol is above 80%. The project will achieve a cluster state production rate at 5 orders of magnitude higher than the current state-of-the-art devices. The successful demonstration of an on-demand cluster state source is a critical step towards scalable and practical photonic quantum architecture.
Schelling’s philosophy of nature and the environmental challenge (SCHELLEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 190242.0
EU funding (EUR): 190242.0
Participants: 2
Project status: CLOSED

The contemporary environmental crisis has triggered a revival of discussions on the concept of nature. Among scientists, philosophers, policy makers and citizens questions regarding environmental practices and the overall state of nature have become a matter of central concern. But what exactly is nature beyond the specific phenomena studied by specialized natural sciences, such as physics, chemistry or biology? Is there something else beyond these particular phenomena? What is the relationship between these phenomena and humanity? Do humans have a special status in relation to nature? On my account, these questions are at the core of the philosophy of nature that Schelling developed at the turn of the 19th century in response to the increasing instrumentalization of nature. More precisely, I take Schelling’s philosophy of nature to address versions of these same questions, especially as regards (a) the unity of nature beyond the phenomena studied by emerging scientific disciplines such as chemistry and biology, and (b) the status of humanity in relation to this unity. The overall aim of the project is to bring out the contemporary relevance of Schelling’s philosophy of nature by investigating it as an attempt to address these challenges. Counteracting mystical readings of Schelling’s project, I will argue (1) that he is concerned with the elaboration of a unified account of the phenomena studied in the natural sciences; (2) that his theory of self-organization aims to provide such an account; (3) that he conceives of the distinction between humans and non-human forms of nature as a distinction of degree; and (4) that this conception of nature as the manifestation of different degrees of self-organization is relevant to contemporary debates in that it forges a middle path between anthropocentric and non-anthropocentric approaches to nature.

Keywords: schelling,philosophy of nature,history of science,self organization,environmental ethics
ClimAte Policy AcceptaBiLity Economic framework (CAPABLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Italy,Switzerland,France,Germany,Spain,Czechia,Netherlands
Call: Improved economic methods for decision-making on climate and environmental policies (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2999430.94
EU funding (EUR): 2999428.0
Participants: 11
Project status: SIGNED

CAPABLE will provide robust, resilient and actionable recommendations for the design of socially and economically acceptable climate policy measures for 2030 and beyond. We will examine past experience, policy design and implementation solutions to identify strategies that can enable a successful transition. We will achieve this by addressing climate, economic, and social challenges. In order to do so, we will draw on economic methods of decision making and policy evaluation, and sociology, political sciences and psychology to capture the multidimensional outcomes and implications of different climate policy instruments. Moreover, we will produce a number of new datasets, and apply state-of-the-art methods to produce new insights on policy perception and performance. Finally, we will integrate the scientific evidence, an interactive stakeholder dialogue, and various dissemination channels including a new online policy tool as a user-oriented service for climate policy-makers at the EU, national, and local level. Taken together, the methodological and empirical advancements will provide broader evidence for desirable climate strategies in Europe, along with lessons for the rest of the world.

Keywords: climate policy,acceptability,feasibility,evaluation,multidisciplinarity
Beyond the current: Improving European flowing waters in an era of global change (BEYOND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Ireland,Germany,Austria,Spain,United Kingdom,Norway,Poland,France,Finland,United States
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2192760.0
EU funding (EUR): 2192760.0
Participants: 37
Project status: SIGNED

BEYOND will train the next generation of water professionals who will deliver scientific and technological innovation across disciplines, institutions and countries needed to solve European water quality problems in an era of global change. In the last decade, some improvement in understanding of water pollution has been achieved but there are still significant knowledge gaps, especially in the context of climate change and emerging contaminants, coupled with a lack of systems approach and operational tools required by water management. To address water quality pressures, we need to better target heterogeneity in the land-water continuum, accounting for recipient-specific sensitivity to pollution pressures and the spatial and temporal variation in sources, pathways, and impacts on stream ecology and ecosystem services, now and under future climatic conditions. BEYOND will equip Researchers with critical technical and communication skills needed to provide evidence-based management of landscapes and river networks under current and future conditions. They will gain expertise in interdisciplinary catchment science, novel high-resolution water quality sensors and models, gain access to cutting-edge water quality instrumentation in experimental catchments in Europe and through secondments to SMEs, and skills in citizen science. BEYOND Researchers will become leaders in innovation and knowledge exchange needed to achieve water quality improvements, through effective interactions with public and private stakeholders during secondments and short visits.

Keywords: streams and rivers,water quality,catchment science,multiple pollutants,global change,hydrological extremes
INCLUSIVE, AFFORDABLE AND SUSTAINABLE HOUSING FOR MARGINALIZED COMMUNITIES (HouseInc)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Czechia,Italy,Romania,United Kingdom,Belgium
Call: Addressing housing inequalities in a sustainable, inclusive and affordable way (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2626566.25
EU funding (EUR): 2626566.25
Participants: 14
Project status: SIGNED

The objective of HouseInc is to apply innovative methodology to deeply analyse interlinked dimensions of housing inequalities in the context of marginalized communities. HouseInc will empirically examine economic, social and ecological drivers and assess impacts of various indicators on housing inequality to derive policy recommendations that foster the adoption of effective measures addressing housing inequality across Europe. With a transdisciplinary dialogue, the project develops innovative social, financial and digital solutions that can be up-scaled and thus, contribute to a better socio-economic and sustainable integration of vulnerable groups in European societies. HouseInc takes a systemic view and assesses interlinkages of housing inequalities - emphasizing energy and mobility poverty, digital dimensions, employment opportunities, family and socio-demographic conditions, energy-efficiency and health - on a micro-, meso- and macro-level. The interdisciplinary HouseInc consortium - consisting of research institutes and universities, policy think tanks, NGOs and practitioners on the ground - involves case studies to engage directly with members of four marginalized communities in or from Eastern Europe. Besides a mix-method approach, including modelling and a GIS-based analysis depicting geographical and future housing inequality, we implement a multinational survey to better understand housing inequality in light of recent events such as COVID-19 and Russia's invasion in the Ukraine. The research results will be assessed, mapped and scaled up using Living Labs and various stakeholder engagement activities to provide innovative solutions addressing housing inequalities and translating them into valid local, regional, national and EU policy recommendations impacting EU and national funding programs and providing a comprehensive overview and guidance for policymakers to mitigate housing inequalities.

Keywords: housing inequalities,energy and mobility poverty,public health,diversity,vulnerable communities,policy,co design methods,social and digital innovations