Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
KiWi Power Limited’s Revolutionary, Low Cost, Demand Response Platform (KDRP) (KDRP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CHALLENGE: Demand response (DR) is central to the successful evolution of a new low carbon electricity system in order to deliver grid flexibility & stability, however it is progressing slowly in the EU due to technological barriers which prevent widespread uptake: high in cost hardware (€4.000 - €6.000); not specifically designed for DR → lack critical functionality (e.g. wireless communication, integration of renewables); & not sufficiently open for wider industry participation. PROPOSED SOLUTION: To address the need for innovations that overcome principal barriers to DR, this project seeks to advance KPLs Energy Management Platform, KEMP, from a prototype demonstrated in a relevant environment (TRL6) to complete & qualified commercial prototype (TRL8). KEMP is a low cost, automated ancillary services platform which consists of: [1] Unique hardware: multi-asset control; first platform to integrate renewable assets; wireless communication between assets → reduced installation cost; & sec. by sec. meter readings – requirement for Frequency Response programmes. [2] Innovative software: cloud based – for greater scalability; flexibility & remote monitoring, forecasting model - for integration of renewables; & optimisation engine - to max. revenues. END USERS: [1] Initial target = large scale commercial & industrial (C&I) orgs with high MW capacity (>1MW) e.g. financial, telecoms, hospitals, hotels etc. Asset types: DRUPS systems & HVAC. [2] Secondary target = SMEs with low MW capacity (50kW< capacity < 1MW) incl. Water Pump Stations, Small Data Centres, Retail Stores. Asset types: Variable Speed Motors, HVAC, UPS systems etc. STUDY OBJECTIVES: tech validation, market analysis, economic & business assessment, operational capacity analysis. Activities will be delivered within a 4 month period, & result in a comprehensive feasibility report detailing the next steps towards development & commercialisation, forming the basis of the SMEI Phase II Business Plan.

Keywords: demand response,cloud computing,smart metering,renewable energy,energy efficiency,eu energy roadmap
Selective glycoimmuno-targeting for cancer therapy (SweetAim)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 1479995.0
EU funding (EUR): 1479995.0
Participants: 1
Project status: CLOSED

Immunotherapy recently became an important alternative to conventional treatment regimes, yet cancer remains a universal leading cause of death. Thus, novel cancer theranostic approaches are still much desired. Although altered cell surface glycosylation is one of the hallmarks of cancer, targeting this ‘sweet aim’ for cancer therapy has been elusive, largely due to carbohydrates poor immunogenicity and the low affinity of antibodies against them. A red meat-derived carbohydrate antigen is a novel immunogenic moiety providing a key to unlock the theranostic potential of tumor-associated carbohydrate antigens. This foreign non-human sugar can be acquired only through the diet and subsequently appears on diverse cell surface glycoconjugates as ‘self’, accumulating mostly on carcinomas, and resulting in a polyclonal xeno-autoantibodies response. I have shown that such antibodies have both diagnostic and therapeutic potential, although basic understanding of their specificity and potency is scarce. The primary objective of this proposal is to design a novel personalized cancer therapeutic approach based on xeno-autoantibodies against the dietary sugar antigen. We propose an innovative interdisciplinary approach crossing the boundaries of cancer research, glycosciences, immunology and nanotechnology, with cutting-edge technologies, to design, engineer, screen and fully investigate potent targeting of ‘SweetAim’ moieties. Our discovery line is based on a two-arms platform to generate optimized antibodies for passive/active therapy, together with refined tumor cells through glyco-engineering/reprogramming for unveiling novel theranostics, finally evaluated both in vitro and in vivo. I expect our groundbreaking achievements will lead to promising new clinical tools, particularly for cancer, but also for other chronic inflammation-mediated diseases. Importantly, it will establish fundamental new concepts regarding carbohydrate recognition and response by the immune system.

Keywords: tumor associated carbohydrate antigen,sialic acid,neu5gc,antibody,xeno autoantibodies,immunotherapy,cancer,cancer vaccine
Linguistic Dimensions of Sexual Normativity (LIDISNO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2020-10-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

LIDISNO is the first large-scale research project that analyses the role of language in the discursive formation of sexual normativity. Based on poststructuralist and Queer Linguistic theorisations of language and sexuality as discursively shaped, the project highlights the historical relativity and variability of sexual normativity by adducing empirical linguistic evidence from various time periods. In contrast to earlier work, which has largely postulated sexuality-related discursive shifts without verifying them in larger amounts of linguistic data, LIDISNO uses corpus linguistically informed critical discourse analysis to study the linguistic corollaries of three sexuality-related normative shifts: 1. language use about a person before and after their public coming out, with US Latino pop singer Ricky Martin as a case study, 2. language use to express same-sex experiences pre- vs. post-Stonewall, and 3. sexuality-related language use before and after 1890, i.e. the time of the oft-cited desire-to-identity shift in the conceptualisation of sexuality. Each of these shifts is studied through comparisons of pairs of text corpora pre- and post-dating the respective shift, while drawing on quantitative and qualitative corpus linguistic methods (frequency of sexuality-related features, frequency lists, keyword lists, semantic keyness, concordances, collocations, colligations) with the help of the tools AntConc and Wmatrix. These linguistic analyses are complemented by a comparison of findings across corpus pairs and comparisons with various types of supplementary data (interviews, personal narratives, major English reference corpora). LIDISNO will improve our understanding how linguistic practices shape sexual normativity. Its findings will be used to advance the theorisation of normativity as an analytical tool in critical discourse studies and to devise language policies that foster greater tolerance and inclusion of non-heterosexual individuals.

Keywords: language and sexuality,critical discourse studies,sexual normativity,corpus linguistics
Carbonyl Sulphide: new ways of Observing the Climate System (COS-OCS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands,Netherlands,Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2462135.0
EU funding (EUR): 927624.53
Participants: 3
Project status: SIGNED

The future climate of our planet strongly depends on the capacity of the biosphere to sequester atmospheric CO2, and on the abundance of stratospheric sulphate aerosols (SSA). These aerosols form a layer that resides at about 16 km altitude that, contrary to CO2, has a cooling effect on climate. These two climate-regulating mechanisms are intricately linked to the atmospheric trace gas carbonyl sulphide (COS). COS is the most abundant sulphur compound in our atmosphere. The dominant COS source is biogenic activity in the ocean, while uptake by the terrestrial biosphere, and a small amount of destruction in the stratosphere, contribute to its removal. The COS loss to the biosphere could potentially be used to quantify photosynthetic CO2 uptake, while its stratospheric destruction is an important precursor for the formation of SSA. A deeper understanding of atmospheric COS variations would therefore signal a major step forward in our ability to diagnose CO2 uptake and SSA formation. With this research program, I aim to fundamentally improve our limited understanding of the COS budget. The program combines innovative modelling and measurements. I aim to collect samples from aircraft, ship cruises, and stations across all latitudes, on which highly challenging analyses of COS and its isotopologues will be performed. To characterise the important transition to the stratosphere, vertical COS profiles up to 30 km will be sampled with so-called “AirCores”. A larger spatial coverage will come from currently untapped satellite data of COS isotopologues. My program will integrate these measurements into the first multispecies and isotope-enabled inverse modelling framework for COS, building on techniques I developed during the past decade. The measurements and model together will allow breakthroughs in the coupled COS and CO2 budgets, and unlock the potential of COS as new climate diagnostic.

Keywords: isotopes carbonyl sulphide climate
Resolving Effects of particle Shape and Inertia in Scalar Transport (RESIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

When small, rigid particles are immersed in a turbulent fluid, they tumble, slip, concentrate and re-orientate themselves amidst a chaotic flow. Simultaneously, material or heat (passive scalars) may be transferred from the surface by convection and diffusion. Nature and engineering are replete with examples: planktonic osmotrophs absorb nutrients from turbulent ocean waters, and industrial processes grow crystals in agitated suspension, to name but two. Such particles are rarely ever spherical. Yet, present approaches overlook this, neglecting the convective transport mechanisms governed by shape and inertia and fail to predict their consequences, for example, in the adaptation strategies of marine diatoms. To address this problem, this project pairs a researcher with experience of fundamental turbulence physics from working in Germany with an expert in applied experimental fluid mechanics at a UK university, achieving a mutually beneficial exchange of knowledge. The Fellow will parametrically survey the effects of aspect ratio and inertia in the mass transfer to ellipsoidal particles, by reacting deformed ion-exchange resin beads in a turbulent solution to determine transport rates as a function of turbulence, fluid and particle properties. This will be followed by a detailed investigation of the underlying flow physics using state-of-the-art laser induced fluorescence and velocimetry techniques, allowing cause-and-effect mechanisms to be established between macro- and micro-scale effects. The project will target its dissemination activities at scientific communities where immediate impact is expected, including chemical and energy engineering and oceanography. This pairing and choice of project, together with the host’s capabilities and track record, will ensure successful completion of this ambitious research project and maximally support the Fellow’s career development.

Keywords: mass transfer,heat transfer,scalar transport,multi phase flow,turbulence,experimental fluid mechanics,particle image velocimetry,laser induced fluorescence
Understanding the global effect of corporate tax reforms (TAXGLOBAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-15
End date: 2022-10-27
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

Despite the wide-spread cross-border operations of firms, the lack of appropriate data has so far precluded a knowledge-based understanding of the international repercussions of corporate tax policies. TAXGLOBAL provides novel insights into the cross-border effect of firm taxation on economic activity. Given the recent tax reform in the United States and a surge of corporate tax reforms to be expected in Europe in the near future (e.g. France, the United Kingdom), such insights are now needed more than ever. It is essential to fully understand and quantify the cross-border impact of corporate tax policy in order to enhance job creation, sustainable investment and productivity growth in a globalized economy. TAXGLOBAL will provide a new understanding of the issue by compiling detailed high-quality data from Norway and analysing it in a quasi-experimental research design. In particular, I will (i) merge several administrative data sets on the domestic and foreign operations of companies which are obtained directly from the administrative and statistical authorities to which they report. This new and unique database will provide an unprecedented opportunity to study in detail the cross-border links on the level of the individual firm. I will (ii) compile a comprehensive and complementary database of all corporate tax reforms in a broad selection of countries to which firms are exposed via foreign affiliates. The information will then (iii) be combined and analysed using state-of-the-art regression models. This integral study of cross-border tax effects using administrative data for multinational firms will advance the research field with new insights into the global effect of tax policy on real business activity, as well as providing policy makers with a novel understanding of the implications of their decisions in integrated economies such as the EU.

Keywords: multinational companies,taxation,globalization
Cellular control of membrane protein density in the endoplasmic reticulum via the unfolded protein response (MemDense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1934065.0
EU funding (EUR): 1934065.0
Participants: 1
Project status: SIGNED

All cells must balance the production of proteins and lipids to maintain membrane functions. Imbalances in protein folding and lipid metabolism cause endoplasmic reticulum (ER) stress associated with a wide range of complex diseases including diabetes, neurodegeneration, and viral infections. The central homeostatic program of the ER is the unfolded protein response (UPR), which senses unfolded proteins in the ER to control protein synthesis, chaperone abundance, and lipid metabolism. Through these mechanisms, the UPR centrally controls decisions between cell survival, adaptation, and apoptosis. The field has focused almost exclusively on soluble proteins as triggers of the UPR, while the more abundant membrane proteins have been neglected. Our finding of UPR activation by membrane aberrancies provides a radically new perspective and allows us to address central questions in membrane and cell biology: How is the density of ER membrane proteins sensed and controlled? How are misfolded membrane proteins recognized to mount adaptive responses? Focusing on the conceptual advance that UPR transducers sense signals from the membrane, we will 1) establish and reconstitute the machinery for sensing membrane protein crowding, 2) identify mechanisms coordinating protein and lipid homeostasis between organelles, 3) study the molecular recognition of misfolded membrane proteins by the UPR. Key to this endeavor is our unique combination of genetic, biochemical, and biophysical tools for parallel characterization of the UPR in vivo and in vitro. Combining this framework with novel strategies for an immuno-isolation of organelles, we are primed to answer how membrane aberrancies cause chronic ER stress. By establishing the UPR as a quality control system for membrane proteins, and providing novel tools and valuable resources to the community, MemDense will have wide impact on our molecular and cellular understanding of ER homeostasis and the many diseases related to ER stress.

Keywords: membrane quality control,unfolded protein response,membrane protein crowding,lipid bilayer stress
PLATform for Operation of distribution NEtworks (PlatOne)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Germany,Italy,Germany,Belgium,Greece
Call: Flexibility and retail market options for the distribution grid (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 9600957.58
EU funding (EUR): 7535148.02
Participants: 12
Project status: SIGNED

To manage energy transition, DSOs require innovative tools. Volatile renewable energy sources in combination with less predictable consumption patterns call for higher levels of observability and exploitation of flexibility. While these two challenges are traditionally treated with separate means, PlatOne proposes an innovative approach to a joint data management for both. Fully respecting the existing regulatory framework, a layered set of platforms will allow to meet the needs of system operators, aggregators and end users. A blockchain based platform is the access layer to generators’ and customers’ flexibilities able to break traditional access barriers by providing certified measures to all the players. In conjunction, certified data and signals will be used for an innovative DSO platform to locally maintain system integrity fostering confidence in flexibility operations. An upper layer will implement a new concept of blockchain-based open market platform to link the local system to the TSO domains and enhance the overall system cost efficiency. Because flexibility means customer involvement, PlatOne puts the grid users at the centre, investigates their needs and expectations and uses the underlying blockchain to unlock the potentials of higher dynamics of response. The platforms will be tested in 3 large pilots in Europe and analysed in cooperation with a large research initiative in Canada. Thanks to strategic partnerships and a unique consortium structure with an excellent network, PlatOne can offer an unprecedented effort of dissemination and exploitation with focus on DSO experts and final users.

Keywords: data platform,flexibility management,blockchain,energy markets
An induced pluripotent stem cell-based neuronal model of Spinocerebellar ataxia (iPSCAtaxia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-01-23
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders defined by a loss of motor coordination. No effective treatments exist, and there is thus a pressing need for suitable models in which to study disease progression and to screen potential therapies. Induced pluripotent stem cells (iPSCs), which are capable of differentiation into any cell type of the body, offer the opportunity to study neurodegeneration in vitro. The proposed study aims to be the first in Europe to establish an iPSC-derived model of cerebellar disease, focusing on two genetic subtypes of SCA - SCA14 and 41. Increasing evidence points towards common pathological pathways shared across multiple SCA subtypes, which could provide novel therapeutic targets. There is also evidence to suggest that abnormalities in Purkinje cell development may contribute to the pathogenesis of the SCAs. This model will thus be used to elucidate the molecular mechanisms underlying common SCA-causing disease pathways, and to unravel the neurodevelopmental aspects of these diseases, in order to develop early-intervention therapies. Preliminary results indicate successful differentiation of iPSCs into cerebellar progenitor cells, using a protocol I have optimised. Following terminal differentiation, these cells will be investigated for common disease phenotypes and developmental defects, using a combination of transcriptomic, biochemical, and electrophysiological methods. Results will be validated by comparison with post-mortem brain samples and ataxic mouse models. By adapting this differentiation strategy to a format amenable to high-throughput screening, a pipeline will be established for the identification of novel therapeutic compounds. This groundbreaking study will enable the investigation of mechanisms which render the cells of the cerebellum particularly sensitive to degeneration, as well as providing a platform for pre-clinical screening of therapeutics for neurodegenerative conditions.

Keywords: induced pluripotent stem cells,cerebellum,neurodegenerative disease,ataxia