Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LIGHTWIND: A DISRUPTIVE DRIVE-TRAIN FOR ULTRALIGHT AND LOWER COST WIND TURBINES (LIGHTWIND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Germany,Poland,Greece,Norway,Denmark
Call: Next generation of renewable energy technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 2994871.98
EU funding (EUR): 2994871.69
Participants: 9
Project status: SIGNED

The current drive-train solutions for bottom-fixed offshore wind turbines do not necessarily work well for floating wind turbines, especially when it comes to increasing the size of the turbines beyond the current state of the art. The increasing nacelle weight makes it difficult to develop floating platforms that are both technically and economically viable beyond 15 MW. Also, high repair costs of current drive-train solutions are making sites far off coast (which would be technically viable for floating wind turbines) economically unacceptable. Innovation is needed to develop new solutions for floating wind turbines that can reduce the weight of nacelle and rotor and subsequently also of the supporting structures, while maintaining or increasing energy production and decreasing repair costs. This project proposes to develop a disruptive, compact and lightweight drive-train solution, that offers significant advantages in terms of mass, turbine and repair costs, scalability, critical materials usage, and social and environmental impacts. The LIGHTWIND project aims at demonstrating the technical feasibility of the concept and at evaluating the economic, social, and environmental benefits by comparing it to existing 15 MW turbine reference models. Additionally, the project will demonstrate that these benefits allow the scaling of floating offshore wind turbines to 22 and 30 MW.

Keywords: wind energy,floating offshore wind,drive train,rotor,lcoe,weight reduction
Comprehensive Surveillance of High-risk Individuals and Health Integration for Early detection of Pancreatic cancer utilising innovative multiplex immunoassays (SHIELD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Innovation actions
Countries involved: Slovenia,Greece,Italy,Sweden,Cyprus,Spain,Denmark,Luxembourg,Belgium,Lithuania,Germany,United Kingdom,Switzerland
Call: Accessible and affordable tests to advance early detection of heritable cancers in European regions (HORIZON-MISS-2024-CANCER-01, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 14066895.07
EU funding (EUR): 11646387.66
Participants: 27
Project status: SIGNED

The SHIELD project seeks to revolutionise early detection of pancreatic cancer, focusing on individuals with high heritable genetic risk. Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 10%, primarily due to late-stage diagnosis. Consequently, 85% of PDAC cases are identified too late for curative treatment. However, early detection can significantly improve outcomes, increasing the survival rate to 42% with surgical intervention. There is a pressing need for better early detection methods, especially for those with familial or genetic predispositions. The only FDA-approved biomarker, CA19-9, is limited to monitoring treatment response due to its lack of sensitivity and specificity, while imaging methods ofter fail to detect early-stage cancers and cause a strain to the healthcare system due to their cost and limited availability. SHIELD aims to validate a new blood-based diagnostic test designed for early PDAC detection in high-risk individuals and pilot an early detection programme in Greece, Slovenia and Lithuania. Developed by partner Reccan, this test uses a 5-plex multiple immunoassay to analyze protein readouts and provides a probability score for pancreatic cancer. Initial studies with over 450 samples showed excellent performance with >91% sensitivity and >96% specificity. The project will validate the test's clinical performance in a prospective multi-center study across seven EU countries, targeting individuals with familial or genetic predispositions. It will also identify new protein biomarkers for other high-risk indications, such as new-onset diabetes (NOD). Collaboration with national screening authorities will help integrate this test into existing programs, and partnerships with patient organizations will enhance recruitment. SHIELD envisions transforming pancreatic cancer diagnostics by increasing the 5-year survival rate to 30% by 2035 in Europe. This action is part of the Cancer Mission cluster of projects on “Prevention & early detection (early detection heritable cancers)

Keywords: pancreatic cancer early detection,multiplex immunoassays,heritable genetic risk,cancer screening
Liposomes as nanoreactors for the bottom-up assembly of supramolecular structures in confined space (LipoNanoReactors)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

Nanoreactors are attractive systems for emerging technologies because they allow the manipulation of matter on a molecular scale to fabricate macroscale products. Consequently, nanoreactors have been used to carry out molecular synthesis and catalysis, where such processes are controlled and stimulated by confined space. However, the current nanoreactors suffer from a lack in the flow-control of substrate that can access their interior and they have not been used to build large supramolecular structures. To overcomes these disadvantages and improve the application of nanoreactors, in this project we propose a novel design of a nanoreactor based on the combination of liposomes and molecular transporters (LipoNanoReactors). We envisage that by a controlled transport of ions (metal cations or organic anions) through phospholipid membranes, we will be able to build supramolecular structures inside liposomes, where the final structure could be modulated by the rate of ion flow and confinement effects. As a result, this strategy will allow us to control the physical and chemical properties of such structures on a nanometric scale. Further than achieving supramolecular assembly inside liposomes, the present proposal looks to facing challenges as supramolecular isomerism, crystalline phase purity, and particle size control. Accordingly, this project opens new horizons in the field of crystal engineering, solid-state chemistry, and material sciences.

Keywords: liposomes,transmembrane ion transport
Proportional Algorithms for Democratic Decisions (PRO-DEMOCRATIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1479938.0
EU funding (EUR): 1479938.0
Participants: 1
Project status: SIGNED

The project is set in the field of computational social choice. We will focus on formal models describing scenarios, where a group of individuals, called voters, disagrees on certain matters, yet needs to make a collective decision. The decision must truly represents a compromise. We focus on group fairness understood as proportionality. There are numerous real-life scenarios that involve collective (public) decisions, and where our solutions could be applied. Examples include: elections of representative bodies (such as parliaments, faculty boards, etc.), participatory budgeting elections (where citizens decide how to allocate a part of a municipal budget), or scenarios where certain local communities (say, housing cooperatives) make series of decisions. In addition, proportional algorithms for making collective decisions can be used for selecting nominees for an award, for constructing rankings of movies or books, for selecting validators in consensus protocols, such as the blockchain, for constructing rankings of web-pages in response to user queries, for locating public facilities, or for improving genetic algorithms. The goal of this project is to develop generic methods of reasoning about equity of treatment of voters, and to design new algorithms that satisfy the most demanding criteria of proportionality. The new methods should be applicable to a number of specific models that concern public decisions. We will (1) prove theorems specifying whether and under which conditions our notions of proportionality are satisfiable, and (2) we will analyse various rules and algorithms with respect to our criteria of proportionality and other important desiderata that are commonly considered in social choice theory. We plan to (3) determine the computational complexity of the problem of finding proportional public decisions, and to (4) develop exact, approximation, fixed-parameter-tractable, and heuristic algorithms for this and related computational problems.

Keywords: computational social choice,participatory budgeting,committee elections
Ecocritical Approach to Land Subsidence in Italy's Po Delta region (EarthSea)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-25
End date: 2025-09-24
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: SIGNED

The phenomenon of land subsidence in river deltas, the sinking of delta’s land surface due to the removal of underground resources, has become a global challenge due to the rise of sea levels, recurrent droughts, and invasive human activities, to the point that by 2040 it will affect almost one fifth of the global population. The accelerating land subsidence in river deltas has been the subject of renewed interest in hydrogeology and environmental policy, in response to a growing concern with the increasing exploitation of the subsoil, further aggravated by the natural gas crisis in Europe. Scientific studies have mostly analysed this phenomenon by focusing on hydrogeological and physical characteristics of the deltaic land. Meanwhile, recent environmental humanities scholars have noted the inadequacy of governmental institutions in managing precarious ecosystems affected by land subsidence. Few researchers, however, have thoroughly examined land subsidence through an interdisciplinary approach to analyse the role of cultural productions – such as cinema and literature – in shaping and giving voice to public understandings of land subsidence. Indeed, a comprehensive ecocritical study of land subsidence has not yet been done. As a result, the scholarship tends to consider the “natural” or “human” aspects of land subsidence in isolation, thus overlooking key, more comprehensive insights for environmental policy and river delta conservation. EarthSea will provide the first comprehensive ecocritical analysis of the ways in which contemporary literature, cinema, and media have actively shaped and contributed to past and present debates over land subsidence. The theoretical and methodological research portions of EarthSea will use Italy’s Po Delta as a case study. The Po Delta represents one of the most important anthropogenic river deltas in Europe and is the largest in Italy, covering 180 km2 and hosting hundreds of animal and vegetable species.

Keywords: environmental humanities,italy
Ecologies of indigenous filmmaking in the Democratic Republic of Congo. (Ind. Eco Film DRC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2026-05-31
Duration (months): 45.0
Total project cost (EUR): 254330.4
EU funding (EUR): 254330.4
Participants: 3
Project status: SIGNED

Environmental films by indigenous filmmakers are circulating increasingly widely on small screens and at major film festivals. They have proved empowering thanks to their potential to rethink the environmental crisis from experience-based perspectives. Despite this, they remain largely unexamined among scholars. This goes especially for indigenous filmmaking in the DR Congo, where communities living in mineral-rich areas crucial for the transition to green economies are being instrumentalised for greenwashing purposes and subjected to environmental racism. Their filmmaking exposes these abuses and reflects upon the environmental crisis’s uneven effects. They contribute to the environmental imagination and their worldviews are crucial for the animist turn in contemporary film studies. This action explores these neglected mediations of the environmental crisis and aims to enrich film studies and the environmental humanities by studying ecological imaginaries. Through critical content analysis, fieldwork involving participative action research and practice-based analyses of audio-visual practices, I probe how these films articulate indigenous perspectives and build agency. The action will be embedded in the Amsterdam School of Cultural Analysis at the University of Amsterdam. Prof. Patricia Pisters, the project’s supervisor, is a leading voice in film studies and the ASCA’s research groups stand to enhance the research significantly. It will benefit from a secondment for additional training at Munich’s Rachel Carson Centre for Environment and Society, ensuring that the project is informed and debated. A non-academic placement at Cobra Films will allow me to build on my participative action research method to deliver a documentary that bridges theory and practice. The project will enable the transfer of scientific knowledge and skills among these three institutions, leverage my future academic career, and facilitate further research, publication, and outreach.

Keywords: film,media,anthropocene,visual culture,ecology,environment,colonialism,cinema studies,indigenous,decolonial,postcolonial,activism,climate,global south,environmental humanities,animism
Revolutionizing AI in drug discovery via innovative molecular representation paradigms (ReMINDER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1494006.25
EU funding (EUR): 1494006.0
Participants: 1
Project status: SIGNED

Artificial intelligence (AI) in the form of deep learning is driving unprecedented progress in numerous fields, e.g., for protein structure prediction and organic reaction planning. In drug discovery and chemical biology, such progress is an “evolution” rather than a revolution: several tasks still await to be solved by AI, e.g., accurate structure-activity and activity-cliff prediction, and design of structurally innovative chemical matter. Increasingly complex deep learning approaches are leading to progressively smaller gains in model capabilities, calling for a revolution in AI for drug discovery. The springboard for this project is a striking observation: while novel deep learning algorithms are in continuous development, the input ‘raw’ molecular representations they rely on (e.g., SMILES strings and molecular graphs) have not considerably changed in the last four decades – limiting the amount and quality of chemical information learnable by AI. The potential of capturing more sophisticated chemical information better into a new ‘molecular language’ is still untapped and bears promise to revolutionize molecular AI. ReMINDER will break with traditional approaches and shift the object of study from increasingly complex algorithms to novel molecular representation paradigms for AI. ReMINDER will be an agent of change in the molecular AI landscape, by developing a new representation framework at the interface between method development and experimental validation. ReMINDER will disrupt the potential of AI to (a) navigate complex structure-activity landscapes, (b) design innovative bioactive molecules from scratch, (c) leverage binding pocket information for molecule discovery. By transforming the chemical information captured for AI, we open opportunities to develop more efficient models and solve open scientific challenges. ReMINDER will create the basis for exciting new technology in the field of deep learning for drug discovery, and chemistry at large.

Keywords: drug discovery,chemoinformatics,molecular representation,ai
Anthropology of Global Climate Urgency (C-Urge)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Mauritius,United Kingdom,Sweden,Germany,Italy,United States
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2674670.4
EU funding (EUR): 2674670.4
Participants: 13
Project status: SIGNED

The overarching objective of this DN is to respond to a growing urgency expressed by European research councils and funding agencies, as well as by governments, publics and students, that the social sciences should contribute to our understanding of and engagement with climate change. We propose that the need for urgent action demands that social science attends to the notion of 'urgency' itself. We want to train doctoral candidates in understanding different perceptions on environmental and climatological urgency, their temporalities, and the political and environmental implications these understandings may have. 10 PhD students will carry out ethnographic research in Africa, Latin-America, Asia or Europe. The researchers will gain non-academic transferable skills in organisations that either disseminate scientific findings, or that work in political or development-related contexts. Experts of 5 European universities (KU Leuven University, University of Edinburgh, Halle University, Uppsala University, and the University of Catania) team up with 6 non-academic partners, and 10 members of the interdisciplinary advisory board in order to ensure that the 10 PhD candidates will receive excellent training opportunities both in academia and outside academia. This ensures the formation of a cohort of junior experts who will be able to contribute to the struggle against the disruptive effects of climate change. C-urge responds to the invitation described in the European Climate Pact to connect and share knowledge about climate change as well as develop, implement and scale up possible solutions and offers a qualitative, innovative, multi-sectoral as well as trans-disciplinary approach to the various degrees of urgency that global climate change inspires. The on-the-ground insights and knowledge that C-urge produces will ultimately strengthen European policy, innovation and responsiveness to climate change and its impacts across the globe.
Doctoral training network TAu imMunE: strategies for innovative diagnosis and therapies in dementia (TAME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Greece,Belgium,Netherlands,Sweden,France,Taiwan, Province of China,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2673698.4
EU funding (EUR): 2431389.6
Participants: 22
Project status: SIGNED

There is an urgent medical need for efficient diagnostics for Alzheimer’s disease and related tauopathies, as well as disease modifying treatments, due to the heavy burden of the disease on patients, families and society. To address this public health issue, TAME R&I training network gathers leading academic and industrial experts in tau research with the ambition to keep older people active and independent for longer. TAME aims to provide better understanding of tau-related diseases and supports the development of new, safer, personalised and more effective diagnosis and interventions for AD and the less common tauopathies. The beneficiaries and partners bring together resources and knowledge across different fields and technologies to provide a multidisciplinary approach necessary to take on the challenge. They have teamed-up to combine molecular and cellular neuroscience with computing, chemical and bio-engineering and their technology expertise. The first tau network of Europe, TAME, will focus on novel approaches using nanobodies, which have emerged as very promising antibody formats in tau research. The primary objective of the TAME is to train 9 fellows to deliver the next generation of talented life scientists. The program will be a combination of training in research, in personal and professional development and in open science, achieved by conducting research projects, attending courses and benefiting from internal mobility within TAME. The research training is based on cutting-edge technologies and advanced models for medical research, emphasizing the need for more human-based research, gender-personalised models and reduction in the use of animals. Consequently, through intense collaboration with all partners and the relevant industrial experience, these 9 fellows can anticipate improved career prospects and higher employability. TAME will provide an innovation-friendly framework in which scientific results can mature and be developed into products.

Keywords: tauopathies,alzheimer s disease,nanobodies,diagnostics,immunotherapy,imaging