Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engine INSTallation And INtegration (EINSTAIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy
Call: Engine Installation Optimization (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 1463500.0
EU funding (EUR): 1060900.0
Participants: 2
Project status: CLOSED

Nowadays, almost all General Aviation piston-powered aircrafts are powered by Avgas fuel. For decades, piston engines like Lycoming and Continental were allowed to burn only this type of fuel, which is characterized by high-octane values, very low vapor pressure indexes and high costs because of its poor production quantity, tracked and certified production and high performances. The “compression ignition” engine can provide a fuel consumption reduction from 30% to 50% compared to Avgas engine. An additional benefit of the replacement of Avgas piston engine with a diesel engine is obtained due to the reduced fuel price. This “compression ignition” piston engines are able and certified to operate with kerosene and/or Jet fuels, so their use is justified in areas, such as Europe, Africa, Russia, China and many others, where aviation gasoline (Avgas, also known as 100LL) cost is significantly higher than jet fuels. Therefore the objective of this project is to demonstrate the feasibility of an efficient “diesel” engine installation on a FAR/EASA Part23, 9 to 11 seats twin engine aircraft configuration and reduce as much as possible the related increase in drag, respect to a conventional engine, by using Computational Fluid Dynamics (CFD) in the design phase. In order to achieve this goal the SR460, a six-cylinders, air/oil-cooled turbo-diesel engine produced by SMA, will be used as reference and installed on the TECNAM P2012 TRAVELLER aircraft. The main advantages are reported as following: • The average fuel consumption will be of around 45kg/hr/engine against an average of 130kg/hr of a turboprop engine; • P2012 will be the first twin engine aircraft available in both "Avgas" and "kerosene" capable variants; • P2012 with SR460 will have a very competitive acquisition cost, comparable to the same-passengers’ capability of the single engine turboprop.

Keywords: engine,compression ignition,avgas,diesel,aircraft,nacelle aerodynamic drag,installation weight,radiator,intercooler cooling
Type 1 reyanodine receptor Structure and regulation by post-translational modifications and small molecules. (channelopathies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

This proposal is aiming at understanding the structural basis of the type 1 ryanodine receptor (RyR1) regulation by post-translational modifications and by small molecules. RyR1 is present on the sarcoplasmic and endoplasmic reticuli of many mammalian cell types, most notably, in skeletal muscles. RyR channels are required for calcium release from intracellular stores, a process essential for excitation-contraction (EC) coupling in skeletal (RyR1) and cardiac (RyR2) muscles. They are amongst the largest ion channels, comprised of the four identical ~565 kDa channel-forming protomers. RyRs channel activity is regulated by post-translational modifications through multiple signaling pathways including adrenergic stimulation. We have obtained a 4.3 Å resolution cryo-electron microscopy (Cryo-EM) structure of RyR1 in the closed state and a 3.6 Å structure in an activated state. An atomic model was built, defining the transmembrane pore, placing all cytosolic domains as tertiary folds and unambiguously identifying small ligands including calcium, ATP, caffeine and the ryanodine in unprecedented details. In both data sets obtained, 3-D classification of particles revealed multiple distinct conformations providing a broad detailed picture of the dynamic process of RyR1 gating. Here, I aim at improving and completing the atomic model of RyR1 and at determining the structural basis for RyR1 regulation by post-translational modifications and by small molecules. I will use X-ray crystallography to determine the high-resolution structure of the full length RyR1 as well as small fragments including the transmembrane pore and drug binding sites. Cryo–EM and 3-D classification will be used to identify structural changes induced by post-translational modifications and by native ligands and drugs binding. The mechanism of drugs targeting RyRs such as dantrolene and rycals can lead to structure-based design of more potent/safer drugs for malignant hyperthermia and muscular dystrophy.

Keywords: ryanodine receptor,calcium release channels,ion channels,protein structure,cryo electron microscopy,excitation contraction coupling,post translational modifications
Identifying the building blocks of episodic memory: how the hippocampus parses boundless experience into discrete events (HippBoundariesPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-18
End date: 2018-08-17
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

Life provides us with a continuous stream of information that ends up being organized in long-term memory as distinct events. How does this occur? Leading theories posit that surprising occurrences (when prediction of the immediate future fails) are interpreted by the system as event boundaries that segment ongoing experience. Will any type of surprise induce such segmentation? Moreover, how are these segments then laid down in memory as discrete units? The proposed research addresses these key issues in a two phase study, combining fMRI of healthy individuals with a neuropsychological study of amnesic patients, and using tailored film clips designed to dissociate between distinct forms of prediction error (PE) – low-level PE (salient perceptual changes) and high-level PE (explicit expectancy of an upcoming change). We hypothesize that the key region in this process may be the hippocampus, a region strongly linked to formation of episodic memory. Combining a 7T fMRI study (enabling distinction between hippocampal subfields) with a study of patients with focal hippocampal lesions will enable us to elucidate the nature and necessity of hippocampal involvement in segmentation. The significance of this study lays first in its potential to illuminate how real-life events are registered to memory, a process which is likely to differ significantly from the encoding of brief, simple stimuli that have been employed previously. The importance of studying encoding of complex events has recently received increasing recognition, yet this is still only at its infancy, with very few studies employing this approach. Combining the complementary expertise of the researcher and the host, the proposed research aims to identify what constitutes an event boundary in mnemonic processing. Through future collaborations, this has the potential to lead to applicable interventions for improving normal memory and ameliorating mnemonic disorders.

Keywords: fmri,episodic encoding,long term memory,event boundaries,amnesia,hippocampus
String topology and group (co)homology (StringHom)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The goal of the project is to use string topology to understand the homology and cohomology of certain highly interesting groups: automorphism groups of free groups and finite groups of Lie type. The project consists of two parts. In the first, the Experienced Researcher (ER) aims to use string topological techniques he has pioneered and proven effective elsewhere to prove the nontriviality of the Morita and Eisenstein cycles in the homology of automorphism groups of free groups, thereby solving one of the big open questions concerning the homology of these groups. In the second part, the ER and the main supervisor will develop the "string topology of finite groups of Lie type" they have recently discovered connecting the cohomology of the free loop space of the classifying space of a compact connected Lie group G and the cohomology of the finite groups of Lie type associated with G with the aim of using it to shed light on the hitherto mysterious Tezuka conjecture asserting that the two cohomologies frequently agree. Hosted at one of the major centres for algebraic topology in the world and supervised by a world leader in homotopical group theory, the project will have a substantial impact on the ER's career by deepening and broadening his research expertise, especially concerning p-compact groups and cohomology of finite groups; by significantly broadening his research network; and by solidifying his position as a trailblazer and leader in applying techniques from string topology to tackle difficult problems in group homology and cohomology.

Keywords: string topology,group co homology,classifying spaces,automorphism groups of free groups,p compact groups,finite groups of lie type,morita cycles,eisenstein cycles,tezuka conjecture
Molecular mechanisms of interferon-induced antiviral restriction and signalling (ANTIViR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2023-11-30
Duration (months): 72.0
Total project cost (EUR): 1499793.77
EU funding (EUR): 1499793.77
Participants: 1
Project status: SIGNED

Interferons (IFNs), which are signalling proteins produced by infected cells, are the first line of defence against viral infections. IFNs induce, in infected and neighbouring cells, the expression of hundreds of IFN-stimulated genes (ISGs). The ISGs in turn induce in cells a potent antiviral state, capable of preventing replication of most viruses, including Human Immunodeficiency Virus type 1 (HIV-1) and influenza A virus (FLUAV). Identifying the antiviral ISGs and understanding their mechanisms of action is therefore crucial to progress in the fight against viruses. ISGs playing a role in the antiviral state have been identified, such as human MX1, a well-known antiviral factor able to restrict numerous viruses including FLUAV, and MX2, an HIV-1 inhibitor. Both proteins bind to viral components but their detailed mechanisms of action, as well as the consequences of restriction on the activation of the innate immune system, remain unclear. Moreover, our preliminary work shows that additional anti-HIV-1 and anti-FLUAV ISGs remain to identify. In this context, this proposal seeks an ERC StG funding to explore 3 major aims: 1) unravelling the mechanisms of antiviral action of MX proteins, by taking advantage of their similar structure and engineered chimeric proteins, and by using functional genetic screens to identify their cofactors; 2) investigating the consequences of incoming virus recognition by MX proteins on innate immune signalling, by altering their expression in target cells and measuring the cell response in terms of gene induction and cytokine production; 3) identifying and characterizing new ISGs able to inhibit viral replication with a combination of powerful approaches, including a whole-genome CRISPR/Cas9 knock-out screen. Overall, this proposal will provide a better understanding of the molecular mechanisms involved in the antiviral effect of IFN, and may guide future efforts to identify novel therapeutic targets against major pathogenic viruses.

Keywords: interferon,antiviral restriction,hiv 1,influenza virus,genetic screens,innate immune signalling
SKilled, Innovative & Entrepreneurial Scientists (SKIES)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: South Africa,Germany,Poland,Netherlands,Netherlands,Portugal
Call: Research innovation needs & skills training in PhD programmes (H2020-SwafS-2020-1, 2020)
Start date: 2021-03-01
End date: 2022-08-31
Duration (months): 18.0
Total project cost (EUR): 312887.5
EU funding (EUR): 312887.5
Participants: 7
Project status: CLOSED

Through the SKIES project, the consortium partners will provide PhD and 1st year postdoctoral researchers in the field of astronomy with a new set of skills integrating open science, innovation and entrepreneurship, thereby equipping them for a career that allows them to fulfill their potential and contribute to society and economy. A Train the Trainer programme builds the capacity of the teaching staff, so that they have the training and tools to continue the programme beyond the life of the project. Online training will be made available to support the partner as well as other organisations interested to run similar courses.
EEN InnoSupp BG-4 (EEN InnoSupp BG-4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 95389.99
EU funding (EUR): 95389.99
Participants: 12
Project status: CLOSED

The main objective of this project is to contribute to the implementation of the European policies in the field of innovation management capacity building in SMEs and their implementation in Bulgaria, resulting in effective and efficient investments in novelties leading to growth and quality jobs. As a major tool for improving global competitiveness of European companies, implementation of novelties in products, processes and society needs specially devoted attention and resources. This project will contribute to the better filtering and acceleration of innovation processes in Bulgarian SMEs, thus supporting growth and jobs. Supported companies are supposed to be better prepared for using Access to Finance instruments and attract investments in innovation.

Keywords: innovation management,internationalisation
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans (MingleIFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-06-15
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.

Keywords: fluorescence,intracellular transport,intraflagellar transport,cilia,kinesin,dynein,single molecule imaging,multi color imaging,chemotaxis,signal transduction,signal response,c elagans
Behaviour, perceptions, cognition, knowledge, organizations. Relational contracting approach to design of contractual forms when information is imprecise. (RelImprecision)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 163099.2
EU funding (EUR): 163099.2
Participants: 2
Project status: CLOSED

This project aims to provide the first analysis of relational contracting when the parties do not (initially) have precise information about the various courses of actions, and experiment them through the relationship. Examples include innovative activeties such as book publishing, research and development, technology adoption in developing countries, and drafting rules and laws in bureaucratic setting. We introduce in relational contracts framework imprecision about the prospects of actions. Imprecision is formulated as ‘ambiguity’ by building on recent developments in decision theoretic literature. The aim in this project is to explore how the interaction of imprecise perceptions about the consequences of actions and moral hazard introduce new conceptual and analytical issues and how such an interaction plays a role in shaping dynamic relational incentives. An understanding of these questions is relevant not only for motivating research and development, but also for diverse applications including technology adoption in developing countries, book publishing, as well as drafting new policies and rules of law. In publishing an author will typically have some imprecise information about the new project as previous experience is only partly relevant for new venture, and possibly better information in writing the book than the publisher. Technology adoption in developing countries is similarly dynamic process of experimentation and learning via relationship. Local entrepreneurs have better yet imprecise ideas about new technologies and new practices than development agencies. In policy making and drafting new rules of laws, uncertainty about various acts can shape the optimal degree of delegation implied by the moral hazard between politicians and between bureaucrats so that evidence-based policy-making can be achieved in a healthy democracy.

Keywords: relational contracts,ambiguity,experimentation,learning
Smart Augmented and Virtual Reality Marketplace for Furniture Customisation (FURNIT-SAVER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Slovenia,Slovenia
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2016-03-31
Duration (months): 14.0
Total project cost (EUR): 1103843.75
EU funding (EUR): 952437.5
Participants: 7
Project status: CLOSED

The European furniture market has undergone dramatic changes in the recent past, with a relatively cottage industry populated by many small companies becoming increasingly dominated by the growth of bulk retailers. The traditional nature of the furniture industry and the limited incorporation of ICT tools, have further reduced the ability of SMEs in the sector to innovate and respond to the competition. These small companies have been unable to compete with the economies of scale advantages that larger retailers can offer. These scale advantages come from offering a wide range of standardised products and selling them to many people. These larger companies also tend to offer relatively cheap and impermanent products that can be replaced if they do not fit the customer's needs. A potential competitive advantages for smaller furniture companies is the ability to provide customised goods that meet the customers' demands and are of greater quality and durability. However, as it is impossible to envisage how the furniture will look and fit into the customers home, customised furniture also bears an expensive risk if the final piece of furniture does not meet the customer's needs. Recent developments in virtual and augmented reality technologies offer furniture SMEs the opportunity to remove these risks. Allowing the customers to see the customised furniture in their home environment and to adapt it to their own particular tastes and needs by using an automatic recommender system, will give creative SMEs a competitive advantage over larger companies. The FURNIT-SAVER project will make use of VR/AR technologies, recommendation engines and a user interface to produce a smart marketplace for furniture customisation. It will enable customers to make accurate 3D plans of the rooms they wish to design, recommend, customise and visualise different furniture, before visualising it in their home environment using Augmented Reality.

Keywords: furniture,creative industries,design,wood,augmented reality,virtual reality,job creation,competition,customisation,marketplace