Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic and behavioral solutions to the nutritional challenges of life in freshwater (FADSEVOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

When invading nutritionally-poor environments, species can expand their functional metabolic niche, by evolving the capacity to synthesize essential compounds, and/or their dietary niche, by evolving new behavioral or morphological traits that enable them to use either novel or rare resources. The relative value of behavioral versus metabolic means for resolving mismatches remains unresolved because these have not been examined concurrently. Omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) are important for consumers, but are scarce in freshwaters compared to marine ecosystems, presenting a challenge for species invading freshwaters. The proposed study will be the first to examine both metabolic and behavioral means for regulating nutritional composition and fitness when invading freshwaters from marine ecosystems. We will examine the dietary niche of threespine stickleback (Gasterosteus aculeatus) in terms of diet variation and foraging preferences, and the metabolic functional niche in terms of genotypes and n-3 LCPUFA synthesis ability. FADSEVOL will be especially innovative by building upon the recently-identified genetic basis of variation in stickleback fatty acid metabolism: FADS2 copy number variation. We will characterize the fatty-acid composition of prey and tissues of lineages that vary widely in their FADS2 copy numbers and history of adaption to freshwater (WP1). Next, we will examine foraging preferences of common garden fish for prey that vary in nutritional composition (WP2). Finally, we will evaluate n-3 LCPUFA synthesis ability, FADS2 expression, and life history traits of lineages in common-garden conditions with high or low dietary n-3 LCPUFA availability (WP3). These approaches will allow us to understand variation in both the functional metabolic niche and the dietary niche, providing insights into how foraging behavior and metabolic evolution can enable consumers to invade nutritionally-challenging ecosystems.

Keywords: fatty acids,fish
Safe Real-Time Systems: Certification Everywhere (Certywhere)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

We trust computers with our lives: they steer our aircrafts, control cardiac pacemakers, insulin pumps, ventilators, and other medical devices, and will soon drive our cars. All these software systems are safety critical: an error in the software may lead to a catastrophe such as the loss of life or the explosion of a rocket. Unfortunately, safety-critical systems have been plagued by fatal software failures from their early days until today. In computer science, verification is the discipline of constructing software and systems that are correct by design. It proves that a computer system works correctly under all given circumstances with mathematical rigor. As real software is far too complex to be analyzed by hand, today, verification itself uses computers to get the job done, i.e. it is understood to be computer-aided verification. With this, the following question immediately arises: If we use a piece of software, say, the verifier, to guarantee that another computer system works correctly, how can we trust the result of the verification process if the verifier itself could have a bug? In my opinion, this is an extremely important question to answer if we are serious about applying computer-aided verification to real-life safety-critical systems. However, surprisingly little has been done to answer it. The goal of Certywhere is to significantly advance the state-of-the-art on this question by marrying the two popular verification methods of automated model checking and interactive theorem proving by means of certification. In this approach, model checkers produce certificates, which can be efficiently checked against the model and formula by an independent formally verified certifier. I want to apply the certification approach to a large range of model checking methods from the important areas of symbolic model checking and partial-order reduction. In particular, I want to target timed automata, which are a popular formalism for verifying real-time systems.

Keywords: certification,model checking,timed automata,interactive theorem proving,isabelle
Fine-Grained Cryptography (FGC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Italy
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2493750.0
EU funding (EUR): 2493750.0
Participants: 1
Project status: SIGNED

Encryption and authentication have long been the workhorse of secure systems, but with the shift towards a decentralized mode of data processing, contemporary cryptographic tools such as secure computation and homomorphic encryption are taking center stage. Unlike their “private-key” counterparts, for which efficient candidate instantiations abound, these “public-key” types of primitives rely on a remarkably narrow base of computational hardness assumptions. Developing and understanding new assumptions upon which such primitives can be based is a necessity; the Fine-Grained Cryptography project aims to do exactly that. Traditionally, cryptography has been based on problems for which there is a conjectured exponential complexity gap between the “easy” and “hard” directions; in contrast, we propose to investigate alternatives where the underlying gap is a sufficiently large polynomial. Practically speaking, fixed polynomial gaps should suffice for concrete security parameter instantiations. From a theoretical standpoint, they yield meaningful results even if P = NP -- a scenario in which most cryptography is (asymptotically) broken. While a rich “fine-grained” complexity theory of moderately hard problems has been developed in the past two decades, its consequences to cryptography remain relatively unexplored. Moderately hard problems abound, and many of them enjoy algebraic and combinatorial structure. This, combined with the existence of tools for average-case analysis, points to their promise as a new base for advanced cryptographic applications. Our initial focus will be on lower-level cryptographic primitives, such as one-way functions and public-key encryption. However, we expect our approach to also have direct impact on the feasibility and practical efficiency of higher-level cryptographic tasks, including advanced forms of encryption and even obfuscation.

Keywords: cryptography,fine grained complexity,average case hardness,public key encryption,obfuscation
Youth negotiation of tourism-based employment in Goa and Lisbon (YouthExistInTourism)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-12-02
End date: 2022-03-02
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

This research focuses on how within two contexts –in the Global North in Lisbon, and in the Global South in Goa – young people negotiate landscapes of touristification and neoliberalisation that relate to their futures. Exponential urban redevelopment, climate change and heightened capitalism manifest in both places through changes made to accommodate an economy focused on tourism-boosting. Austerity in Portugal, and a boost to tourism-centred jobs in Goa has resulted in young people leaving in search of jobs elsewhere. However, a large portion continue to stay back in these geographies and are employed by the tourism industry which paradoxically gentrifies them. This research will aim to understand how young people make sense of their futures through new, gig economies in rapidly changing job landscapes, whilst simultaneously making space for themselves by negotiating this very environment - they therefore resist while also existing. It will consider potential conflicts and shared understandings, while making sense of the entanglements of youth job cultures, future considerations, and the relationship to a sense of place. Sharing a history, albeit of colonialism, (Portugal colonised Goa from 1510 until 1961 after which the latter was taken over by India) makes for a novel perspective of Global North-South as well as a post-colonial dynamic which is missing from existing knowledge. The project will use a cross-cultural case study approach, with qualitative research methods in line with critical ethnography. The project will be strengthened by the multi-disciplinary background of the researcher in sociology and geography, alongside contribution from other disciplinary perspectives through researchers at the host institution. It aims to create both academic outputs as well as material and content for public engagement and dissemination.

Keywords: youth studies,tourism in society,youth career futures,young people in work
GluCl as an epileptic seizure autoregulatory Gene therapeutic approach (AutoStopS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-15
End date: 2018-01-14
Duration (months): 18.0
Total project cost (EUR): 137591.1
EU funding (EUR): 137591.1
Participants: 1
Project status: CLOSED

This Horizon2020 – Marie Sklodowska Curie Actions – Individual Fellowship grant proposal focuses on the development of a new gene therapy approach targeting intractable epilepsy, with the major aim to achieve autoregulation of seizure detection and termination. For this purpose, a glutamate-gated chloride channel (GluCl; cloned from C. elegans) will be expressed in excitatory neurons in the rodent brain using a viral vector and a human CamKIIα promoter. In response to increased glutamate levels, as present during epileptic seizures, the channel activates and opens a Cl- conductance. This, in turn, inhibits excitatory neurons and causes seizure suppression. As a further advantage, an “add-on” therapeutic approach with the GluCl agonist ivermectin, an approved antihelminthic drug, is available. In principle, the gene therapy could therefore confer both an autoregulatory effect to the transduced brain region and have an external “gain control” exerted by pharmacological modulation. Taken together, my Fellowship proposal aims to develop a radically new antiepileptic strategy to treat drug-resistant, refractory epilepsy, which affects approximately 1 million people in Europe.
Aerial Release of Mosquitoes (MOSQUAREL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-05-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

MOSQUAREL (Aerial Release of Mosquitoes) The REVOLINC project (ERC Consolidator grant no. 682387) aims at developing environmentally-friendly alternatives to fight insects invasions through the development of biological technologies to control three types of pest insects (mosquitoes, tsetse flies and Mediterranean fruit flies), two of which are presently invading Europe. We want to improve the « sterile insect technique » which consists in mass rearing male insects, sterilizing them by radiation and releasing them into the environment, where they compete with their wild, non-sterile counterparts to reproduce. The « boosted sterile insect technique » consists in ensuring that the males also transmit biopesticides to the females that kill them or their progeny. It is mandatory to develop alternative methods to insecticides that raise concern for their toxicity for health and environment, particularly against mosquito vectors in the context of Zika virus epidemics. The proposed technology necessitates the release of sterile males, preferably by air. There is presently no aerial system to release mosquitoes which are all released by ground using obsolete methods (cages open at the back of a vehicle…). In the proposed PoC, we want to (1) initiate collaboration with a private company to produce two versions of mosquito releasing drones compliant with EU regulations (C1 and C2 classes), (2) confirm the efficiency of these systems to release sterile male Aedes albopictus in three sites (La Réunion island and Montpellier in France and Valencia in Spain) and (3) start the commercialization process for these drones. The system will become available for other mosquito control technologies involving the release of mosquitoes transfected with symbionts blocking virus transmission or transgenic mosquitoes.

Keywords: drone,automatic release,human health,vector borne diseases,aedes,tiger mosquito
Transferring Activomics into the Clinical Setting (TACTICS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Transferring Activomics into the Clinical Setting (TACTICS). Advancing our proprietary biomarker discovery tool, Activomics, into the clinical laboratory represents an exciting milestone in the introduction of this disruptive technology to the global diagnostics market. Unlike current protein-concentration focussed diagnostics, such as ELISA and MS proteomics, our approach switches the emphasis towards the enzymatic activities of a subset of these proteins, vital cell-signalling enzymes inextricably linked to disease and its progression. We have developed highly sensitive methods to detect Activomic biomarkers in blood. Screening of sera obtained from large patient cohorts led us to identify a novel Activomic biomarker that can differentiate IBD (Inflammatory Bowel Disease) patients from healthy and unhealthy controls with high accuracy (86%) and sensitivity (86%). This first effective serological marker for IBD promises to be a major breakthrough in the diagnostics and/or prognostics of this debilitating disease that counts millions of sufferers worldwide. In Europe alone, over 1 million people currently have the disease, bringing with it a major toll on public health and a concomitant heavy economic burden for the healthcare system and taxpayer. Better diagnosis and targeted therapy of IBD would reduce suffering and costs alike. We participate in this call in order to achieve this goal, allowing us to devise a comprehensive business plan that will act as a roadmap to bring our biomarker into clinical diagnostic laboratories. SME-phase 2 funding and/or further private investment will be sought using the detailed business plan in order to fully validate clinical utility.

Keywords: inflammation chronic disease ibd enzyme activity cell signal disruptive omics
In praise of community: shared creativity in arts and politics in Italy (1959-1979) (INCOMMON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy,Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2022-03-31
Duration (months): 70.0
Total project cost (EUR): 1452685.91
EU funding (EUR): 1398685.91
Participants: 2
Project status: CLOSED

INCOMMON will be the first study to systematically analyse the field of performing arts as resulting from the practice of commonality both theorized and experienced over the 1960s and the 1970s.In particular, the project is aimed to study the history of the ‘laboratory Italy’ as the place where artistic counterculture expressed by performing arts arose in a milieu characterized by a profound relation between philosophy, politics, and revolutionary practices. The overall objectives of INCOMMON are i) to study, collect and contextualize those encounters between theatre, music, visual arts, cinema and video art that assumed the form of performances, especially those created as collaborations between artists; ii) to apply the concept of ‘will-to-the-common’ to the art field of the counterculture; iii) to underline the significance of artistic communities in the local and international scene; iv) to create a digital archive of the performances of the Italian artists of the period. The project will connect historical, philosophical and artistic debates to those in other sciences, sociology and in particular Social Network Theory,in order to reveal significant structures of meanings in the artistic community and to reveal the peculiar characteristics of shared creative processes.The methodology that will be developed is meant 1) to produce new ways of modelling the knowledge and interpretation of performing arts and 2) to create an innovative form of digital archive visualization, where rich interfaces will sustain and improve the understanding of the context and relationships analysed. INCOMMON will produce a comprehensive approach, oriented toward collection, digitization, restoration and dissemination of direct documentation and related materials of the Italian performing arts production of the great creative, political, existential wave of the counterculture, preserving and making accessible a patrimony that otherwise will continue to be lost to future generations.

Keywords: networking between artists,counterculture,intangible heritage,digital archives
Transported cultural landscapes: the role of colonization processes in cultural landscape shaping (ULISSES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-01-20
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

European landscapes are the result of millennia of socio-cultural exchange through trading, migratory and colonial processes. Societies largely dependent to their local ecosystems and when societies move their landscapes move with them, creating in this way the ‘so called’ transported landscapes. The Mediterranean Sea has been the cradle and contact route of ancient and influential civilizations, but little is known about how cultural exchanges, migratory and colonial processes contributed to the cultural landscape shaping of Mediterranean environments. This ancient Mediterranean cultural landscape development achieved a universal importance when, during the colonization of America, the transport of European agro-pastoral landscapes configured a shared cultural landscape heritage between both World regions. Despite its significance in cultural landscape shaping, the study of transported landscapes has been poorly addressed so far. ULISSES project is designed to (1)identify the environmental impacts, land-uses and landscape changes involved in migratory and colonization processes during the Holocene and (2) evaluate the role of transported landscapes in the shaping of cultural landscapes both in Europe and overseas. An integrated approach joining multi-proxy palaeoenvironmental analyses (eg. pollen, non-pollen palynomorphs, charcoal analysis, sedimentology), and the study of archaeo-historical sources will be applied in Mediterranean areas of Spain and California (USA). These have been selected for having ancient colonial relationships and for accounting for a long and intense history of colonial, migratory and socio-economic exchanges. By analyzing the cultural dimension of landscapes and the mobility of cultural landscapes, ULISSES will significantly contribute to 1)a better understanding of the European Mediterranean cultural landscape heritage, 2) the formation of European identities and cultures and 3) the influence of European culture and societies in the World

Keywords: transported cultural landscapes,colonization,human environmental relationships,mediterranean coast,multi proxy palaeoecological analyses,pollen,late holocene,spain,california