Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A new postdoctoral fellowship to address grand societal challenges (EPFLeaders4impact)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Switzerland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 8827200.0
EU funding (EUR): 4413600.0
Participants: 1
Project status: SIGNED

EPFL is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. Its mission is to provide first-rate education, foster pioneering research, and promote cutting-edge technological innovation.As one of the world’s top technical universities and as a leading actor driving disruptive innovation in Switzerland and beyond, EPFL is playing a critical role in the transition towards a sustainable society. Such transition requires not only new knowledge and technology but also responsible scientific leaders with an ability to think across boundaries, to envision all-encompassing solutions to critical societal problems, and to communicate their research to policymakers. EPFL has been integrating sustainability into the training of Bachelor, Master, and PhD students. The EPFLinnovators4impact programme will go one step further by integrating sustainable innovation into the training of postdoctoral researchers who wish to be part of the next generation of sustainable science leaders. Given that the majority of PhD holders eventually choose to pursue another career path than academia, it is crucial to build their entrepreneurial and leadership skills and to focus on sustainable entrepreneurship for those who have developed the required skills and knowledge to address global sustainability challenges during their PhDs. EPFLinnovators4impact is is intended for experienced researchers who have the ambition and the potential to provide innovative solutions addressing one or several of the United Nations Sustainable Development Goals. This innovative programme will provide postdoctoral fellows with funding, training, lab facilities, and expert advice allowing them to develop a novel and impactful product or service. In the course of the programme, they will be able to evaluate the potential for the commercialization of this product or service before founding a startup or licensing intellectual property to an existing company.

Keywords: postdoctoral fellowship,sdgs,impact,innovation,entrepreneurship,startups,technology transfer,training
Infinite-dimensional symmetries, black holes, and holography (HoloBH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

The study of infinite-dimensional symmetries has become a very important theoretical tool in high energy physics. Playing a fundamental role within the context of AdS/CFT holographic correspondence, infinite-dimensional symmetries and their associated mathematical structures have recently reappeared with renewed forms and in a large variety of setups, suggesting an expansion of the scope of the holographic paradigm. Carrying extremely rich information, the algebraic architecture of field theories with infinite symmetries has led to disclose unexpected interrelations between seemingly disconnected results of theoretical physics; such as the relation between soft graviton theorems and the asymptotic symmetries of flat spacetimes, or the conformal invariance governing the near horizon physics of highly spinning black holes. This research project is aimed at investigating different applications of infinite-dimensional symmetries and holography in theoretical physics, with the main attention focused on black hole physics. Specific problems to be addressed include: a) the microscopic computation of non-supersymmetric black holes thermodynamics in non-AdS spaces; b) the exploration of viable extensions of AdS/CFT correspondence to non-AdS spaces, including both warped deformations of AdS, alternative asymptotics for Kerr/CFT, and asymptotically flat spacetimes at null infinity; c) infinite-dimensional symmetries emerging at the near horizon region of non-extremal black holes. This project includes both the transfer of knowledge and skills to the host institution and the training of the researcher in new advanced techniques in the field. As major impacts, the proposal will enhance the future career prospects of the researcher, due to the outstanding training provided by the host, as well as foment further collaborations between the host and other European institutions in the field.

Keywords: gravitation holography,black holes,asymptotic symmetries
Bio-Imaging of Zoonotic and Emerging Bunyaviruses (BIZEB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Finland,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1998375.0
EU funding (EUR): 652741.26
Participants: 2
Project status: CLOSED

We aim to understand host cell entry of enveloped viruses at molecular level. A crucial step in this process is when the viral membrane fuses with the cell membrane. Similarly to cell–cell fusion, this step is mediated by fusion proteins (classes I–III). Several medically important viruses, notably dengue and many bunyaviruses, harbour a class II fusion protein. Class II fusion protein structures have been solved in pre- and post-fusion conformation and in some cases different factors promoting fusion have been determined. However, questions about the most important steps of this key process remain unanswered. I will focus on the entry mechanism of bunyaviruses by using cutting-edge, high spatial and temporal resolution bio-imaging techniques. These viruses have been chosen as a model system to maximise the significance of the project: they form an emerging viral threat to humans and animals, no approved vaccines or antivirals exist for human use and they are less studied than other class II fusion protein systems. Cryo-electron microscopy and tomography will be used to solve high-resolution structures (up to ~3 Å) of viruses, in addition to virus–receptor and virus–membrane complexes. Advanced fluorescence microscopy techniques will be used to probe the dynamics of virus entry and fusion in vivo and in vitro. Deciphering key steps in virus entry is expected to contribute to rational vaccine and drug design. During this project I aim to establish a world-class laboratory in structural and cellular biology of emerging viruses. The project greatly benefits from our unique biosafety level 3 laboratory offering advanced bio-imaging techniques. Furthermore it will also pave way for similar projects on other infectious viruses. Finally the novel computational image processing methods developed in this project will be broadly applicable for the analysis of flexible biological structures, which often pose the most challenging yet interesting questions in structural biology.
Connecting Statistical Mechanics and Conformal Field Theory: an Ising Model Perspective (CONSTAMIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 998005.0
EU funding (EUR): 998005.0
Participants: 1
Project status: CLOSED

The developments of Statistical Mechanics and Quantum Field Theory are among the major achievements of the 20th century's science. During the second half of the century, these two subjects started to converge. In two dimensions, this resulted in a most remarkable chapter of mathematical physics: Conformal Field Theory (CFT) reveals deep structures allowing for extremely precise investigations, making such theories powerful building blocks of many subjects of mathematics and physics. Unfortunately, this convergence has remained non-rigorous, leaving most of the spectacular field-theoretic applications to Statistical Mechanics conjectural. About 15 years ago, several mathematical breakthroughs shed new light on this picture. The development of SLE curves and discrete complex analysis has enabled one to connect various statistical mechanics models with conformally symmetric processes. Recently, major progress was made on a key statistical mechanics model, the Ising model: the connection with SLE was established, and many formulae predicted by CFT were proven. Important advances towards connecting Statistical Mechanics and CFT now appear possible. This is the goal of this proposal, which is organized in three objectives: (I) Build a deep correspondence between the Ising model and CFT: reveal clear links between the objects and structures arising in the Ising and CFT frameworks. (II) Gather the insights of (I) to study new connections to CFT, particularly for minimal models, current algebras and parafermions. (III) Combine (I) and (II) to go beyond conformal symmetry: link the Ising model with massive integrable field theories. The aim is to build one of the first rigorous bridges between Statistical Mechanics and CFT. It will help to close the gap between physical derivations and mathematical theorems. By linking the deep structures of CFT to concrete models that are applicable in many subjects, it will be potentially useful to theoretical and applied scientists.

Keywords: statistical mechanics,conformal field theory,ising model,schramm loewner evolution,discrete complex analysis,representation theory
Smart Transition of EU cities towards a new concept of smart Life and Economy (mySMARTLife)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Germany,Spain,Spain,Finland,Bulgaria,Croatia,Poland,France,France,France,France,France,France,France,France
Call: Smart Cities and Communities lighthouse projects (H2020-SCC-2016, 2016)
Start date: 2016-12-01
End date: 2022-09-30
Duration (months): 70.0
Total project cost (EUR): 21156114.61
EU funding (EUR): 18656102.41
Participants: 49
Project status: SIGNED

mySMARTLife project aims at the development of an Urban Transformation Strategy to support cities in the definition of transition models, as a suitable path to reach high level of excellence in its development process, addressing the main city challenges and progressing to the smart people and smart economy concepts. The main instrument to achieve this very ambitious strategy will be the definition of the Advanced Urban Planning, consisting of an integrated approach of the planned city interventions on the basis of a rigorous impact assessment, an active citizen engagement in the decision-making process and a structured business approach, from the city business model perspective, to the economic framework for big companies and local SMEs and Start-Ups. Nantes (France), Hamburg (Germany) and Helsinki (Finland) are the lighthouse cities and Varna (Bulgaria), Bydgoszcz (Poland), Rijeka (Croatia) and Palencia (Spain) the followers. All of them will be involved in the overall project development assuming different and complementary roles. Energy and Climate mitigation plans in the lighthouse cities are completely compliant with the objectives of Covenant of Mayors initiative, as it is reflected; first regarding the early participation of the cities in Covenant of Mayors and second, considering the ambition of their SEAPs, that were submitted, evaluated, approved and are monitored by Covenant of Mayors. Aligned with these objectives, the commitment of the lighthouses is the deployment of a big set of large scale interventions and at least two years of data collection to make a depth analysis of the results, calculating standard KPIs, evaluating the associated impacts and disseminating the results. Followers will be very close to this demonstration, collaborating in the definition and deployment, analysing the problem from the point of view of their own city challenges and extracting knowledge, best practices and lessons learnt for a further replication.

Keywords: smart people,smart economy,integrated planning,urban transformation strategy,lighthouse cities,follower cities,demonstration,replication
PatIent specific bONE RepositionING (PIONEeRING)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Netherlands
Call: SME business model innovation (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The goal is to develop and commercialise an innovative and easy to use online portal and 3D surgical planning software, and two new patient-specific radius implant products to correct bone deformities. Both products will revolutionise future reconstructive surgery and planning since they enable accurate bone reconstruction with minimum surgical effort. Results for the: Consortium: A completely new online portal and 3D surgical planning software will be developed based on patient-specific anatomy from a standard CT-scan of the affected bone and the contralateral bone. The software enables accurate planning of reconstructive surgery for each patient. It helps designing the implant products semiautomatically. The implant manufacturing procedure will be developed using 3D metal and polymer printing. 3D printing gives full freedom of design, allowing to optimise the implant’s (internal) shape and mechanical load transfer and may render the surgical procedure minimally invasive. Surgeon and patient: With the new online 3D surgical planning portal, surgeons will have worldwide access to an implant design service. Once designed, the implants are manufactured and shipped to the surgeon in 36 hours. Implant design happens online in close cooperation between surgeon and biomedical engineer. This approach and the new implant products renders surgery simpler and yields objective bone positioning. Patient discomfort due to residual malpositioning will be prevented since positioning is accurate, which improves the outcome. The cosmetic result is better. The improvements enable a quick return to daily activities. Hospitals: Our solution will provide top referent care while reducing health-care costs. Based on Amsterdam's Academic Medical Center’s first experience and publications [Dobbe,Vroemen] surgeons expect a reduction of: 30% in surgery time, 40% in reoperation rate and 35% in hospital stay.

Keywords: patient specific implants
AmyloAge: balancing proteostasis and metabolism in age-related muscular degeneration (AmyloAge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

After the age of 30, our muscle strength declines by ~14% per decade. In up to 40% of the elderly, this decline culminates in sarcopenia (SP), critically low muscle mass, causing impaired mobility and longer hospitalizations. Muscle decline rates vary greatly between individuals due to genetic and environmental factors. Yet, our lack of insight into these factors impedes developing effective measures against SP. SP is clinically similar to inclusion body myositis (IBM), the most common myopathy in the elderly, and their molecular phenotypes are very similar. Preliminary data from my host lab, the Laboratory of Integrative Systems Physiology (LISP), show that high-fat diet induces amyloid-containing aggregates in the muscles of aging mice. Such aggregates are hallmarks of muscle proteinopathies such as IBM. Hence, these diseases may be the pathological extremes of natural protein aggregation in the muscle. LISP recently described the protective, therapeutic role of activating mitochondrial stress responses in aggregation diseases. Activating these pathways prevents aggregate formation in cells, worms and transgenic Alzheimer’s mice. I thus hypothesize that mitochondrial dysfunction worsens the pathology of muscle aggregation diseases and SP. My project AmyloAge will explore natural aging in muscle in large, genetically diverse populations of worms, mice and humans. I will use my expertise in proteomics to study the evolution of muscle protein composition and find the genetic determinants associated with unhealthy protein aggregation and muscle decline. With my expertise in biostatistics, I will build an analysis pipeline to find the genes and molecular pathways responsible for protein aggregation and metabolic dysfunction in the muscle. AmyloAge will increase our knowledge of the molecular and physiological variability in muscle aging. This will lay the groundwork for preventive interventions against SP and protein aggregation diseases like IBM.

Keywords: muscle proteinopathies,genetic reference populations,systems genetics
JOINing of copper to aluminium by ElectroMagnetic fields (JOIN-EM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Italy,Austria,Spain,Italy,Germany,Belgium,Belgium,Belgium,France,France,France,France,France
Call: Industrial technologies for advanced joining and assembly processes for multi-materials (H2020-FoF-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 4715912.5
EU funding (EUR): 4127029.0
Participants: 16
Project status: CLOSED

Global trends force industry to manufacture lighter, safer, more environmentally-friendly, more performant, and cheaper products. Due to its excellent thermal and electrical conductivity, copper is widely used in heating and cooling equipment and electrical devices. The rising demand caused the copper price to increase significantly. Solving the conflict between the technological benefits arising from the excellent properties of copper and the disadvantages regarding cost and weight is possible by substituting current full copper parts by copper-aluminium hybrid parts. Within JOIN’EM, such components will be produced by electromagnetic pulse welding (EMW). EMW is a high-speed joining technology using pulsed magnetic fields. The joint is formed without heat, but due to the impact of the joining partners. Disadvantages associated with conventional technologies are avoided and high-quality dissimilar material combinations can be joint. In JOIN’EM, strategies for the process and tool design shall be developed for joining copper-aluminium connections and for 2 other specific material combinations. Profile-shaped components as well as sheet metal applications will be regarded. For joint optimisation, surface preparation, design of the joint geometry, and other aspects will be investigated. A multi scale simulation strategy will be developed for determination of acting loads, deformation, impacting conditions, joint formation, and load capacity of the joint. Designing durable and efficient tools is an indispensable prerequisite for the industrial implementation of the technology and will be addressed in the project. The applicability of the process design strategy shall be validated based on industrial applications. Process and equipment design strategies will be evaluated in an industrial setting. This includes automation and quality control, economic efficiency calculations, life-cycle, and recycling issues, to demonstrate and quantify the advantages of EMW.

Keywords: joining by electromagnetic forming,aluminium,copper,joining technologies,mechanical engineering,heating and cooling applications,electrical applications,magnetic pulse welding
The listening challenge: How ageing brains adapt (AUDADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 1967000.0
EU funding (EUR): 1967000.0
Participants: 1
Project status: CLOSED

Humans in principle adapt well to sensory degradations. In order to do so, our cognitive strategies need to adjust accordingly (a process we term “adaptive control”).The auditory sensory modality poses an excellent, although under-utilised, research model to understand these adjustments, their neural basis, and their large variation amongst individuals. Hearing abilities begin to decline already in the fourth life decade, and our guiding hypothesis is that individuals differ in the extent to which they are neurally, cognitively, and psychologically equipped to adapt to this sensory decline. The project will pursue three specific aims: (1) We will first specify the neural dynamics of “adaptive control” in the under-studied target group of middle-aged listeners compared to young listeners. We will employ advanced multi-modal neuroimaging (EEG and fMRI) markers and a flexible experimental design of listening challenges. (2) Based on the parameters established in (1), we will explain interindividual differences in adaptive control in a large-scale sample of middle-aged listeners, and aim to re-test each individual again after approximately two years. These data will lead to (3) where we will employ statistical models that incorporate a broader context of audiological, cognitive skill, and personality markers and reconstructs longitudinal “trajectories of change” in adaptive control over the middle-age life span. Pursuing these aims will help establish a new theoretical framework for the adaptive ageing brain. The project will further break new ground for future classification and treatment of hearing difficulties, and for developing individualised hearing solutions. Profiting from an excellent research environment and the principle investigator’s pre-established laboratory, this research has the potential to challenge and to transform current understanding and concepts of the ageing human individual.

Keywords: audition,cognition,fmri,speech,neural oscillations,hearing,psychology,ageing,longitudinal