Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accelerating Research & Development for Advanced Therapies (ARDAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Spain,Spain,Italy,Israel,Finland,Sweden,Switzerland,Switzerland,Belgium,Hungary,France,France,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,Portugal,Portugal,United Kingdom
Call: Accelerating research & innovation for advanced therapy medicinal products (H2020-JTI-IMI2-2019-18-two-stage, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 25490491.75
EU funding (EUR): 11772999.75
Participants: 34
Project status: SIGNED

Major current hurdles for wide clinical use of AAV vectors are attributable primarily to: (i) host elimination by both immune and non-immune sequestering mechanisms – such neutralization by host antibody responses critically limits the possibility of repeated AAV delivery; (ii) AAVs are prevalent in the environment and hence a large proportion of the population carry AAV antibodies (up to 80%)– this pre-existing immunity renders AAV unable to infect target cells forcing substantial patient cohorts to be excluded from clinical trials. The current proposal is founded on compelling track record in the field and brings together a ‘best-with-best’ multidisciplinary team of international leading academic and EFPIA partners with complimentary expertise in gene therapy, immunology, chemistry, engineering, biotechnology, drug safety, viral vector production, regulatory and clinical trials. The overall goal is to analyse the currently available clinical data and then design preclinical and clinical studies to fill the knowledge gaps in advanced therapies development. Our main aims are to: 1) Develop improved model systems for predicting product immunogenicity in humans. This will be achieved by generating human and NHP 3D hepatic models; 2) Enhance our understanding of gene/cell therapy drug metabolism inside a host of cell types. The plan is to define metabolism of the therapeutic vector genome in different cell types to understand whether rates of degradation, episomal maintenance, or integration, and metabolic stress induced by AAV vector transgene expression vary from cell to cell. We will then adopt strategies to mitigate the loss of vector genomes and improve persistence; 3) Use diverse clinical expertise to establish the clinical factors around pre-existing immunity limiting patient access to advanced therapies therapy; 4) Engage regulators to ensure that the concepts and the data generated through this IMI programme will fill the gaps and support furture trials.

Keywords: gene therapy,cell therapy,rare disease
Structural role of protein splicing factors in promoting an active configuration of the spliceosome's RNA catalytic core (SpliceosomeStructure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

The spliceosome is a ribonucleoprotein machine that excises introns from pre-messenger RNAs. During my phD, I identified RNA ligands for the magnesium ions that catalyze these splicing reactions and showed that the spliceosomal U6 and U2 small nuclear RNAs form a structure resembling group II self-splicing intron RNAs. Although the spliceosome's catalytic core is RNA-based, numerous spliceosomal proteins promote the proper catalytic fold of this RNA core, juxtapose the reactive pre-mRNA elements with the U6 metal sites, and regulate spliceosome dynamics during the splicing cycle. Indeed, the Prp8 protein cross-links with the critical nucleotides of the catalytic RNA core and its crystal structure, reported recently by the host laboratory, revealed a cavity that accommodates the catalytic RNA core. Moreover, several helicases, such as Brr2 and Prp16, promote an active configuration of the U2/U6 RNA core and associated proteins and regulate their dynamics. The arrangement of such proteins in the assembled spliceosome and their interactions with the RNA core is presently unknown due to the lack of high-resolution structures of any spliceosomal complexes. I will study biochemically in vitro the interactions between the U2/U6 core and key proteins necessary for an active fold of the RNA core, with the goal of reconstituting and solving the high-resolution structure of a minimal active U2/U6 RNA core in complex with the reactive pre-mRNA sites and surrounding proteins including Prp8. In parallel, I will employ recent advances in cryo-electron microscopy sample preparation, imaging, and data processing, which were pioneered at the host institute, to obtain high-resolution (at least 7 Angstroms) three-dimensional reconstructions of endogenous fully assembled spliceosomes stalled at specific splicing stages. These studies promise to provide unprecedented structural insihgt into the configuration and dynamics of key RNA and protein elements of the spliceosome.

Keywords: rna splicing,rna protein interactions,rna protein complexes,spliceosome,x ray crystallography,cryo electron microscopy
Auctions for Renewable Energy Support: Effective use and efficient implementation options (AURES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Spain,Germany,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark
Call: Market uptake of existing and emerging renewable electricity, heating and cooling technologies (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 1552600.75
EU funding (EUR): 1552600.75
Participants: 10
Project status: CLOSED

Auctions, as a competitive and market-based mechanism, are on the verge of becoming a prevailing feature in support policies for renewable energy in Europe. A comprehensive assessment of auctions and their suitability for renewable support in Europe is urgently needed to facilitate their successful design and cost-efficient implementation. Auctions have the potential to significantly improve the performance of renewable electricity support in Europe, but there are potential pitfalls and difficulties to be avoided. AURES combines dedicated, detailed and target-oriented analysis of auctions and their interactions with other energy policy mechanisms and markets with capacity building of policy makers and market participants. The project will identify and evaluate suitable auction design options and their effects under different market conditions using tailored theoretical, empirical, experimental, and model-based approaches, and so develop best practices and policy recommendations for future auction design. Building on worldwide experiences with auctions in energy policy and other industries and on close cooperation with ongoing auction implementation cases in Europe, a strong knowledge base will be developed, enabling policy makers and market participants to make informed decisions. This knowledge base will be processed in a flexible policy support tool that provides policy makers with tailor-made information suited to their specific situation and policy preferences. By facilitating an intense and continuous stakeholder dialogue and by establishing a knowledge sharing network via workshops, webinars, bilateral meetings, and expert consultations, the project will serve as capacity building platform. The project consortium consists of eight renowned public institutions and private firms representing seven European countries and includes some of the leading energy policy experts in Europe, with an impressive track record of successful research and coordination projects.

Keywords: renewable support policies,auctions,competitive market mechanisms
Rhythms In Social Interaction (INTERHYTHM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Social interactions are ubiquitous and our globalized society challenges us with increasingly complex social environments. Yet, evolution has equipped humans with a unique capacity to navigate our social worlds, namely the capacity for rhythmic interpersonal coordination. Despite its relevance, social neuroscience studies have largely ignored this phenomenon, due to methodological constraints inherent in the nature of social interaction. In light of new technological advancements, however, the overarching aims of the proposed project are: (1) to implement an interdisciplinary psychological and neuroscientific approach and a novel experimental methodology that combines Virtual Reality (VR) and functional Near-Infrared Spectroscopy (fNIRS), in order to (2) understand how social interaction is both expressed in and shaped by rhythmic interpersonal coordination on both a behavioural and a neural level, and to (3) determine whether individuals with autism spectrum disorder (ASD) and typically developed individuals differ in their capacity to rhythmically coordinate their motor actions. Thus, the proposed interdisciplinary project combines social psychology research with technical virtual reality innovations and envisages behavioural (synchroneous tapping paradigm), neuroimaging (fNIRS) and clinical (ASD) implementations. It will result in a high-quality scientific programme with long-term potential, by laying the groundwork for the adoption of the concept of “Social Interaction Rhythms” in social neuroscience.

Keywords: social interaction,neuroimaging,fnirs,virtual reality,interpersonal coordination,rhythm,synchronization
a cyberSecurity Platform for vIrtualiseD 5G cybEr Range services (SPIDER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Italy,Cyprus,Greece,Greece,Romania,Greece,Switzerland,Bulgaria,Greece,Greece,France,United Kingdom,Denmark,United Kingdom
Call: Cybersecurity preparedness - cyber range, simulation and economics (H2020-SU-DS-2018, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 7461352.47
EU funding (EUR): 5746595.0
Participants: 21
Project status: CLOSED

The increasing complexity of the telecommunication domain’s cyber threat landscape intensifies the need for new security solutions and for improving the technical security skills of experts and non-experts in the multi-tenant and multi-service environments coming with the domain’s 5th generation (5G). At the same time, attack mechanisms are increasingly sophisticated, pervading critical infrastructures despite billions of euros invested in cybersecurity measures. To address the above, SPIDER delivers an innovative Cyber Range as a Service platform that extends and combines the capabilities of existing telecommunication testbeds and cyber ranges into a unified facility for (i) testing new security technologies, (ii) training modern cyber defenders in near real-world conditions, and (iii) supporting organisations and relevant stakeholders in making optimal cybersecurity investment decisions. At its core, it is a highly customisable dynamic network modelling instrument that enables real-life virtualisation and real-time emulation of networks and systems. It also offers real-time interaction and information sharing capabilities by acting as a serious gaming repository for multiple stakeholders to share material and maximise efficiency in delivering complex cyber exercises. SPIDER’s gamified learning environment enables trainees to master how to use domain-specific cyber protection technologies and collaboratively improve their ability in handling incidents and risks. Complemented by cyber econometric capabilities, SPIDER also enables users to forecast the evolution of attacks and their associated economic impact through the application of innovative risk analysis methodologies, econometric models and real-time attack emulation. The proposed cyber range model will be validated in five highly realistic pilot use case scenarios aimed at demonstrating its applicability and validity for all requirements of the SU-DS01-2018 Call (simulation, training, and economics).

Keywords: network function virtualisation,attacker emulation,serious games,gamified learning
Modular, scalable, multi-funtional, high power density power controller for electrical taxi (E-TSIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Modular, scalable, multi-function, high power density power controller for electric taxi (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 2121428.75
EU funding (EUR): 1650000.0
Participants: 2
Project status: CLOSED

This proposal presented by Indra Sistemas and CEIT jointly, try to answer in the best way the call JTI-CS2-2014-CFP01-SYS-02-02. The referred call and this associated proposal are framed inside of the packet 4.1.2.4 (Modular power controller for advanced landing system) of the System ITD for the Cleansky2 project. This project will develop a next generation power controller for electric taxi. This controller shall feature increased power density, bidirectional power conversion, modularity, scalability, and multifunctionality to support wide range of aircraft applications. Inside this global project of aircraft electrical moving on ground (e-TAXI), this concrete WP, try to answer the necessity of electrical power converters to: - Supply new electrical motors inside of the landing gear system (getting energy from electrical sources inside the aircraft) - Re-charge dedicated batteries inside the aircraft for the landing gear system. This function will help to have additional power available in batteries to be used when necessary, as in acceleration moments. Moreover, the re-charge will be done when aircraft speed on ground is enough or there is a necessity of braking (producing electrical braking over the motors). Then, proposal solution in this call develops a solution answering both functions and getting a global optimization of the system. This solution is done in accordance with aeronautical standards (environmental constrains), where the participants in this proposal have a vast experience. This proposal is presented by the consortium INDRA & CEIT that have all competences and skills to develop this project in time and performances, based in its experience in bidirectional and modular power electronic converters and well-known aeronautic standards, rules and process, more when Indra base its business in manufacturing of aeronautic equipment and system, totally verified and qualified.

Keywords: power conversion,power density optimization,modular,more electrical aircraft,electrical taxi,power components
Elucidating the molecular mechanism of cohesin-loading (Cohesin loading)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: TERMINATED

The cohesin-complex mediates sister chromatid cohesion from S-phase until mitosis and is involved in the formation of higher-order chromatin structure. To fulfill these vital functions, cohesin is loaded and positioned in the genome by mechanisms that are only poorly understood. In vitro, loading of cohesin on DNA only requires ATP and a loading-complex formed by Scc2-Scc4, while loading in vivo on chromatin is regulated by additional factors. For example, in Xenopus laevis oocytes, cohesin loading strictly depends on pre-replication complexes (pre-RCs), which are formed in telophase/G1. Mechanistic studies are required to understand how cohesin-loading occurs at the molecular level. I will first determine the mechanism by which Scc2-Scc4 loads cohesin on DNA. Using single-molecule FRET and optical tweezers, I will monitor the effect of Scc2-Scc4 on conformational changes of cohesin as it is loaded on a DNA template. After characterizing this minimal loading reaction, I will reconstitute cohesin-loading during telophase/G1 using a purified system. With these experiments I will address why and how loading of cohesin is regulated by the formation of pre-RCs.

Keywords: cohesin,sister chromatid cohesion,chromatin,cohesin loading
Mechanical Chirality: Synthesis, Properties and Applications at a New Horizon in Supramolecular Stereochemistry (MechaniChiral)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1998927.5
EU funding (EUR): 1998927.5
Participants: 1
Project status: CLOSED

Molecular chirality is a central theme in chemistry; in 2015 approximately 13% of publications in J. Am. Chem. Soc. and 12% in Angew. Chem. concerned chirality. All previously studied forms of molecular asymmetry (central, axial, planar and helical chirality) have found applications throughout the sub-disciplines of chemistry including as catalysts, materials and sensors. Mechanically chiral rotaxanes are molecules in which the mechanical bond between a macrocycle and dumbbell-shaped component is the source of asymmetry rather than the covalent structure of the components themselves. These unusual molecules represent a novel and unexplored chiral supramolecular environment as the lack of a scalable synthetic approach for their isolation in enantiopure form has prevented all but the most cursory investigation of their properties. Thus, mechanical chirality remains an unexplored frontier of molecular asymmetry with the potential to deliver novel functions and impact across a range of chemical disciplines from materials chemistry to the synthesis of pharmaceutically active compounds. The Goldup Group has recently demonstrated the first practical method for the synthesis of enantiopure mechanically chiral rotaxanes using a flexible active template methodology and thus the stage is finally set for the study and exploitation of this novel form of supramolecular asymmetry. Within the period of this ERC Consolidator Grant the PI will lead a team to investigate the synthesis, properties and applications of these intriguing mechanically chiral molecules.

Keywords: rotaxane,molecular machines,mechanically interlocked
Kahun - an interactive medical knowledge base, for modeling medical knowledge and managing diagnostic processes, as well medical knowledge related to COVID-19. (Kahun)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 3393568.75
EU funding (EUR): 2375498.13
Participants: 1
Project status: CLOSED

Medical errors are recognized as a world-wide problem - this includes mistakes in performing Differential Diagnosis resulting in sending patients to unnecessary tests, missing vital tests, and additional mistakes along the patient management process. In E.U countries alone, medical errors amount to 750,000 Million errors a year, resulting 3.2 million more hospitalizations, 260,000 permanent disabilities and 95,000 deaths each year. The product is a smartphone application (and a web-based version), designed for doctors and medical students. Inspired by crowd-based platforms, its database is regularly updated using a dedicated editor for inputting medical definitions, concepts, and references from the professional medical literature, and for annotating the knowledge and defining relations between elements. So far, Kahun has already established an exclusive database for Internal Medicine's ontology, comprising of more than 50 thousand elements and relations. Kahun's innovative Bayesian algorithms, identify probabilistic relations between the elements in the database - within the tens of thousands of elements scattered across many layers of depth, it creates a massive knowledge graph of probabilistic relationships within the medical ontology. By now, Kahun generates more than 3 Million insights for relations between medical concepts. Kahun allows users to enter variables such as symptoms and lab test results, and presents them a Differential Diagnosis, along with a clear Path to Evidence – track leading from variables to possible result, presented in a graphical correlations map between all elements and with specific references from the literature, and it provides a series of suggestions for patient management such as which lab tests or imaging are the best next step. The company plans to expand the knowledge graph into additional medical fields and provide even greater value. The company expects to reach total revenues of €207 Million by the end of 2026.

Keywords: bayesian algorithms,medical differential diagnosis,smartphone application,covid 19,corona virus,symptomizers
The Quantum Entropy of Extremal Black Holes (BHLOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The research proposed here is principally aimed at computing the full quantum entropy of black holes in string theory, especially in scenarios with reduced supersymmetry, by using localisation to evaluate supersymmetric path integrals. As an additional feature, we shall also explicate how more refined information about quantum black holes, rather than just the total number of microstates, may be extracted by these means. We shall further explicate the recently noticed appearance of mock modular forms in computations of black hole entropy in string theory.

Keywords: black holes in string theory,cft correspondence