Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigation and Control of Hydrogen flames Across the Scales (ICHAruS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Australia,France,United Kingdom,Netherlands,Germany,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2923588.8
EU funding (EUR): 2681280.0
Participants: 13
Project status: SIGNED

ICHAruS is a Doctoral Network aimed to train early-stage researchers, able to face current and future challenges in the field of innovative, edge-cutting technologies based on electro-magnetic assist to achieve full control of the hydrogen flames. ICHAruS has been built to provide doctoral training in a collaborative partnership between academic and industry partners who are major European gas turbine manufacturers. The aim of this partnership is thus to understand the physical processes that govern the interaction between hydrogen combustion and electro-magnetic fields at all flow scales to achieve such control and identify the key parameters that would allow for the design of an innovative, ultra-low NOx and flashback-proof combustion device. The behavior of hydrogen flames under plasma discharge and electromagnetic conditioning offer the opportunity to strongly accelerate the path towards zero-carbon energy and transport sectors. Three specific research objectives will be pursued: 1) Investigation and modelling of electromagnetic field effects on the species transport and chemical kinetics to unveil the effect of external electromagnetic fields on the reaction chemistry of hydrogen in both pure oxygen and air, and also determine any effects on the formation of pollutants. The effect of differential diffusion on the flame structure as opposed to electromagnetic drift will be also investigated. 2) Develop turbulence combustion models for low- and high-energy electromagnetic assisted combustion. The competing effects between electromagnetic drift and turbulence transport will be investigated and sub-grid scale closures for large-eddy simulations that consider the effect of electromagnetic fields and plasma will be developed. 3) Experimental and numerical investigation of innovative electromagnetic-assisted control technologies for the stabilisation of flames of practical interest. Both single swirl flames and annular configurations will be investigated

Keywords: hydrogen combustion,plasma assisted combustion,electromagnetic field,large eddy simulations
#StrongerTogether: SSAH and the Future of Evidence-Informed Policymaking (STEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Other Culture, creativity and inclusive society destinations
Action type: Coordination and support actions
Countries involved: Belgium
Call: Presidency event (BE) - Conference ‘Combining SSAH and STEM expertise in evidence-informed policymaking’ (HORIZON-CL2-2023-SSAH-STEM-PRES-IBA, 2023)
Start date: 2024-02-13
End date: 2025-01-12
Duration (months): 11.0
Total project cost (EUR): 341500.0
EU funding (EUR): 300000.0
Participants: 1
Project status: SIGNED

This conference under Belgium Presidency aims at engaging in a dialog with experts in the field of SSAH, knowledge brokers and policymakers with a view to improve the contribution of the SSAH disciplines in evidence-informed policymaking. By way of interactive discussions organised by NIDO (the social innovation lab of the federal government) and using the coaches of LUMEN (the network of coaches of the federal government), the discussions will focus on three main topics: production (of evidence, of evidence-informed policies, of research calls, of brokerage organisations - within government or in academia), professionalisation (where we discuss the roles, the responsibilities, the skilling and rewarding and communication between the actors in the EIPM system) and innovations.

Keywords: eipm,ssah,stem,policy making,knowledge brokers,conference
H2Global's innovative double-auction mechanism to support the global clean hydrogen market ramp-up (H2Global)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Innovation Procurement Awards
Action type: Recognition Prize
Countries involved: Germany
Call: Facing societal challenges category: - “Net Zero Industry Procurement” (HORIZON-EIC-2024-PRIZE-EIPA, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Renewable hydrogen and its derivatives are crucial in the fight against the global climate crisis, providing a carbon-free alternative to fossil fuels. Produced from renewable energy, they are key for decarbonizing hard-to-electrify sectors such as heavy industry and shipping. The H2Global instrument, implemented by Hintco, was created to accelerate the market ramp-up of renewable hydrogen and its derivatives to help meet Europe’s ambitious net-zero goals. The innovative double-auction mechanism connects producers and buyers of renewable hydrogen and its derivatives through competitive auctions where producers offering the lowest and buyers offering the highest price are selected. Hintco bridges the gap between high production costs and low ability to pay, ensuring that projects move from planning to large-scale implementation. By simulating a functioning market through its double-auction mechanism, H2Global solves the "chicken-and-egg" problem of low demand and insufficient supply. The current €900m tender funded by the German Federal Ministry for Economic Affairs and Climate Action is devided into three lots. This application focuses on the H2Global pilot auction on e-ammonia (Lot 1) concluded in July 2024. The procurememt process started with a call for expressions of interest in December 2022. Over 1,000 parties in 65 countries downloaded the tender documents. In June 2023, Hintco invited bidders to submit indicative proposals and entered into contract negotriations with five companies. These companies submitted their final bids and the winner was awarded the contract: Fertiglobe, a large producer of nitrogen fertilizers and a pioneer in sustainable ammonia. H2Global’s flexibility allows governments to design tenders tailored to their own financing, sustainability criteria, and geographical scope. By mobilizing both public and private capital, H2Global offers a scalable solution for driving the green hydrogen market and achieving a net-zero industry.

Keywords: hintco,h2global,renewable hydrogen,renewable ammonia,global energy transition,double auction,market ramp up,net zero,climate change mitigation,carbon free,price signals,european market
MERGING SUSTAINABLE AND DIGITAL CHEMICAL TECHNOLOGIES FOR THE DEVELOPMENT OF GREENER-BY-DESIGN PHARMACEUTICALS (SusPharma)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Belgium,Netherlands,United Kingdom,Portugal
Call: Green pharmaceuticals (HORIZON-HLTH-2021-IND-07, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 6205435.0
EU funding (EUR): 6205434.5
Participants: 10
Project status: SIGNED

Safe- and green-by-design are pre-market design approaches whereby the objectives of minimizing the use of hazardous chemicals, reducing greenhouse gas emissions, and fostering the reuse and recycling of materials in a circular economy are built into product design. SUSPHARMA fits the European need for sustainable development in modern industry and will develop during the action greener routes to prepare molecules, such as therapeutics and diagnostics. The breakthrough innovation will involve: - use of renewable (bio-based) carbon for the building block of scaffolds and motifs for drug synthesis; - cleaner synthetic methodologies for C-X bond formation (that is, C-H functionalization to obtain C-C, C-F, and C-I bond formation); - development of new benchtop continuous purification methods, to remove impurity and recycle synthetic solvents; - integration of digitalization methods. - LCA and TEA assessment for sensibly reducing the impact of pharmaceutical production. The project will thus benefit from an interdisciplinary domain, involving: - recent advances in biomass conversion for drug synthesis; - new developments in heterogeneous catalysis; - cutting-edge flow chemistry technologies (including synthesis and purification); - automation and machine learning. To address the challenge of green and digital transition and proper supply of health technologies and products, SUSPHARMA will focus on research and innovation activities that aim at integrating five breakthrough concepts: CAT-to-PHARMA, WASTE-to-PHARMA, FLOW-to-PHARMA, PUR-to-PHARMA, and DIGITAL to PHARMA. This will deliver results that are directed to pharmaceutical industries, researchers, and innovators, prompting them to develop and produce greener pharmaceuticals that are either greener by design, intrinsically less harmful for the environment, or use greener and economically more sustainable manufacturing processes and technologies.

Keywords: flow chemistry,synthetic chemistry,pharmaceutical synthesis,green chemistry,heterogeneous catalysis,crystallization,chromatography,biomass conversion,process intensification,process chemistry
MultiomIcs based Risk stratification of Atherosclerotic CardiovascuLar disEase (MIRACLE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Finland,Netherlands,Germany,Sweden,Norway,Portugal
Call: EIC Pathfinder Challenge: Cardiogenomics (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4599866.25
EU funding (EUR): 4599866.25
Participants: 9
Project status: SIGNED

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Aside from asymptomatic manifestations, the first sign of clinically significant ASCVD is often a severe clinical event, such as stroke or myocardial infarction (MI). Thus, identifying individuals at high risk is crucial in preventing the fatal consequences of ASCVD. Current risk prediction models based on traditional risk factors, such as SCORE2, have limitations since they do not encompass all mechanisms and intermediary phenotypes leading to ASCVD. Particularly, current risk models fail to consider the disturbance of gene regulatory networks (GRNs) caused by genetic risk factors and diverse longitudinal exposures accumulating during a person's lifetime.Furthermore, the current models predict the combined risk of CAD, PAD and ischemic stroke despite mounting evidence of the heterogeneity of the underlying disease mechanisms. To capture the missing aspects of current ASCVD risk scores, MIRACLE project brings together unique data resources and expertise to provide novel multiomics based prediction models of ASCVD. We aim to (1) Integrate the globally largest CAD, PAD, and stroke GWAS information to identify genetic loci that differ between or are shared by these diseases and their subtypes, (2) Identify sex-specific subtypes of ASCVD patients using transcriptomic phenotyping of plaques and circulating biomarkers, (3) Generate functionally informed polygenic risk scores by combining experimental fine-mapping and gene prioritization approaches with integrative GRN and deep learning modelling. (4) Derive novel risk prediction models incorporating polygenic risk and circulating biomarkers. Providing a new gold standard for prediction models to accurately risk stratify stroke and MI represents a technological breakthrough allowing for earlier diagnoses and treatments of ASCVD.

Keywords: atherosclerotic cardiovascular disease,coronary artery disease,peripheral artery disease,stroke,risk prediction,score2,biomarker,gene regulatory network,transcriptomics,proteomics,metabolomics
Oxytocin regulates marmosets’ affiliation and vocal communication (MarmOTChat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1398750.0
EU funding (EUR): 1398750.0
Participants: 1
Project status: SIGNED

Primate social interactions rely heavily on visual and acoustic signalling. Yet little remains known about how social context affects how vocalisations are perceived and produced, and the neural mechanisms that support this this process. Given the complex dynamics that typify primate societies, addressing such questions remains of critical importance to elucidating the mysteries of the primate social brain. I hypothesize that oxytocin (OT), a neurohormone that regulates social behaviour and a promising therapeutic target for psychiatric disorders, influences context-dependent effects on primate vocal communication, notably by acting in higher order brain regions involved in vocalisations and encoding social information. I propose to explore the neural basis of socially adapted acoustic communication. To do so, I will record vocalisations from marmoset monkeys, a highly vocal primate and promising model for neuroscience, in different social contexts designed to elicit positively or negatively valenced calls between differently affiliated monkeys. Importantly, these experiments will happen in semi-natural conditions, focusing on freely moving animals expressing their normal behaviours within the colony. This is a highly novel approach that starkly contrasts with classical task-based experiments. Additionally, using modern tools including high throughput neurophysiology, chemogenetics and intravenous viruses, I will manipulate OT neurons activity while recording from hundreds of neurons. This will enable analyses focusing on neural populations instead of single units, all wireless and without interfering with the animals’ behaviours. This multidisciplinary approach will allow me to uncover some fundamental aspects of how the primate brain encodes natural conversations and adapts its response accordingly to the social context. Moreover, I will for the first time study how endogenous OT controls social behaviours in primates.

Keywords: oxytocin,marmoset,neurophysiology,acoustic communication,social behaviour
Research Analysis Identifier SystEm (RAISE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: Greece,Spain,Luxembourg,Netherlands,Cyprus,Sweden,Belgium,Italy,United Kingdom,Canada,France
Call: Innovative and customizable services for EOSC (HORIZON-INFRA-2021-EOSC-01, 2021)
Start date: 2022-10-01
End date: 2026-01-31
Duration (months): 40.0
Total project cost (EUR): 4836125.0
EU funding (EUR): 4836125.0
Participants: 21
Project status: SIGNED

The mission of RAISE is to provide the infrastructure for a distributed crowdsourced data processing system, moving from open data to open access data for processing. RAISE will provide the mechanism for sending the algorithm to the dataset instead of sending the data to the algorithm. The real value of open data for the research community is not to access them but to process them as conveniently as possible in order to reduce time-to-result and increase productivity. RAISE aims at promoting a transparent way of sharing and processing data, enabling the research community to publish their work with evidence-based authenticity of the data-analysis performed, ensuring at the same time the accreditation of their work. RAISE will be grounded on the fundamental principle defined in the FAIR Guiding Principles for scientific data management and stewardship (Findability, Accessibility, Interoperability and Reusability). To do so, RAISE brings the processing algorithm (small size) to the dataset (large size) instead of downloading the dataset to the computer where the processing algorithm is. To increase the processing capacity of the dataset repositories, RAISE borrows the crowdsourcing concept where researchers can easily integrate in the existing workflows computers serving both their datasets and the processing capacity. RAISE will produce the following Outputs: 1. A trustworthy crowdsourced network of RAI Certified nodes offering data storing and processing resources 2. The RAI Cloud platform to orchestrate the data sharing, processing and finding. 3. The Research Analysis Identifier ? RAI , a unique identifier of any result along with the dataset information and the processing script, without disclosing any source code or raw data. 4. Dataset plagiarism identification and dataset proof-of-origin services, to maximise the level of trust of the RAISE system. 5. The RAI Synthetic Data Generator

Keywords: crowdsourced data sharing and processing network
Crete Renewable Energy Valley (CRETE VALLEY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Greece,Spain,Portugal,Luxembourg,Slovenia,Germany,France,Ireland,Italy,Denmark,Belgium,Cyprus,Austria
Call: Renewable Energy Valleys to increase energy security while accelerating the green transition in Europe (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 25251083.75
EU funding (EUR): 19960911.88
Participants: 41
Project status: SIGNED

CRETE VALLEY aims to create a Renewable Energy Valley 'Living Lab' (REV-Lab) in Crete. It is envisioned as a decentralised renewable energy system that combines leading-edge ICT technologies, interoperable and open digital solutions (including data sovereignty), social innovation processes, and sound business models that are easy to adopt. CRETE VALLEY will demonstrate a digitalised, distributed, renewable, low carbon landscape that is affordable for all and fully covers the local energy needs on an annual basis, utilizing multiple renewable energy carriers and leveraging energy storage technologies. The REV-Lab will integrate four Community Energy Labs (CELs) located in distinct sites across CRETE VALLEY, conceived as Innovation Hubs. An integrated social, technological & business approach will be deployed, providing: A Social Science Framework for REV-Labs & CELs, innovative multi-level governance models & social-driven mechanisms for involving citizens in the co-design, implementation and exploitation of RES; AI-based market segmentation algorithms, MCDA methods and consensus analysis for REV configuration; Interactive tools for REV planning (REV Readiness Assessment & computation, Augmented Reality applications, decision support tool); Energy Data Space compliant digital backbone for consumer and REV-level data-driven ‘activation’; P2P DLT/Blockchain digital marketplace for tokenised energy and non-energy assets valuation and reciprocal compensation; Data-driven operational analysis, advanced AI/ML tools and flexibility modelling services for optimal operation & resilience of the local energy grid; System-of-system Dig. Twin for multiple carrier grid management & operation; Data-driven services and apps for energy efficiency and activation performance management towards energy autonomy; Enabling RES technologies to increase the power production; REV Business Sandbox and blueprints for REV-Lab setup, upscaling and replication (including 4 Follower Communities).

Keywords: energy citizens ssh consumers activation energy data space marketplace data driven services rev planning multiple carrier grid management demand response business models
Anticancer approach based on the Metabolic Disruption of Cancer Stem Cells with high effectivity across a wide range of solid tumours (MEDiCS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Portugal,Germany
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2894962.77
EU funding (EUR): 2498015.63
Participants: 5
Project status: SIGNED

By combining advanced synthetic chemistry with cancer biology, we have demonstrated the potential of ruthenium complex IGN116 as an effective and tolerable anticancer agent, inhibiting tumour proliferation as early as 1-2 days post treatment in pre-clinical PDX models. Instead of acting as a cytotoxic agent, IGN116 interferes with the key bioenergetic pathway (aerobic oxidative phosphorylation) utilized by Cancer Stem Cells (CSC), drastically effecting their stemness potential whilst keeping other cells essentially unaffected. This mode of action is novel both among organometallic and CSC-targeting drugs, conferring IGN116’s effectivity with unmatched low secondary toxicity. Through its unique mechanism of action, IGN116 provides the opportunity to tackle the specific therapeutic challenges of two particularly concerning cancer types that will be the focus of MEDICS: Therapy resistance in the high incidence CRC (1.9 million new cases and 608,000 deaths/year); and poor prognosis in treatment-refractory PDAC (495,773 cases, 466,003 deaths/year). The current TRL is at 3-4 having demonstrated in vivo efficacy, confirmed mechanism of action, and completed full toxicity pharmacokinetic (PK) studies of the isolated IGN116, both in in-house studies and in external CRO-led validation. In MEDICS, we will further develop IGN116 for CRC and PDAC progressing towards TRL5 through: Development of a scalable manufacturing process amenable to GMP; Advancement towards GLP in-vivo studies; and Creation of a spin-out to take the product development towards commercialization. MEDICS will thus tackle a critical challenge in European healthcare: delivering safe and effective cancer treatments, with the potential of benefitting 43,800 CRC and PDAC patients per year in Europe alone by 2040.

Keywords: cancer stem cells,anticancer agents,metal based therapeutics,colorectal cancer,pancreatic cancer,solid tumours,ruthenium