Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular and cellular determinants of cell monolayer mechanics (MolCellTissMech)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Epithelial monolayers are amongst the simplest tissues in the body, yet they play fundamental roles in adult organisms where they separate the internal environment from the external environment and in development when the intrinsic forces generated by cells within the monolayer drive tissue morphogenesis. The mechanics of these simple tissues is dictated by the cytoskeletal and adhesive proteins that interface the constituent cells into a tissue-scale mechanical syncitium. Mutations in these proteins lead to diseases with fragilised epithelia. However, a quantitative understanding of how subcellular structures govern monolayer mechanics, how cells sense their mechanical environment and what mechanical forces participate in tissue morphogenesis is lacking. To overcome these challenges, my lab devised a new technique to study the mechanics of load-bearing monolayers under well-controlled mechanical conditions while allowing imaging at subcellular, cellular and tissue resolutions. Using this instrument, my proposal aims to understand the molecular determinants of monolayer mechanics as well as the cellular behaviours that drive tissue morphogenesis. I will focus on four objectives: 1) discover the molecular determinants of monolayer mechanics, 2) characterise monolayer mechanics, 3) dissect how tension is sensed by monolayers, and 4) investigate the biophysics of individual cell behaviours participating in tissue morphogenesis. Together these studies will enable us to understand how monolayer mechanics is affected by changes in single cell behaviour, subcellular organisation, and molecular turnover. This multi-scale characterisation of monolayer mechanics will set the stage for new theoretical descriptions of living tissues involving both molecular-scale phenomena (cytoskeletal turnover, contractility, and protein unfolding) operating on short time-scales and rearrangements due to cell-scale phenomena (cell intercalation, cell division) acting on longer times.

Keywords: epithelium,cytoskeleton,f actin,intermediate filaments,adherens junctions,desmosomes,intercellular adhesion,actin cortex,biophysics,cell mechanics,tissue mechanics,optogenetics,fret
Not all minds that wander are lost: A neurocognitive test of mind-wandering state’s contribution to human cognition. (WANDERINGMINDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-12-01
End date: 2020-05-31
Duration (months): 54.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: CLOSED

Experience does not always arise from the events in the immediate environment; research has shown that states such as mind-wandering occupy almost half of our waking thought. Although mind-wandering has gained a foothold in cognitive science, our understanding of this core form of cognition is piecemeal and disjointed, making it a regular topic of theoretical debates in high-profile journals (e.g. Science and Psychological Bulletin). I have argued that these controversies are due to the lack of a coherent framework in which to explore mind-wandering’s role in cognition. In particular, a key problem is overcoming simple views that propose that mind wandering is merely a state that leads to errors, or unhappiness; accounts that persist in the face of evidence that it contributes foresight and originality to human thought. This project will allow me to assemble a team of researchers and develop an account of how mind-wandering contributes to creative and novel thinking and how it can be regulated to prevent interference with ongoing action. We will explore the experiential categories of the state using novel experience-sampling methods I have developed and explore its neural basis using functional Magnetic Resonance Imaging (fMRI). Using these measures, we will: (i) identify the neural correlates of different categories of mind-wandering experiences, (ii) use these metrics to explore the mechanisms that underlie the creative properties of thinking during mind-wandering, (iii) identify how this creative mode of thought is managed so as not to disrupt important goals in the here and now (such as learning) and (iv) explore these processes in the context of both controlled laboratory studies and longitudinally in the real world by assessing their beneficial role in academic performance. This project will redefine our understanding of mind-wandering as a vital and dynamic element of the mental lives of every member of our species.

Keywords: mind wandering,neurophenomenology,creativity,prospection
Social Vulnerability and its Intersections: The role of gender in a comparative perspective (VINe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

VINE seeks to disentangle the multidimensionality of the risk of social exclusion, focusing on vulnerable populations; specifically, those individuals who are in a fragile condition with regard to integration into the domains of well-being (family, labour market, welfare state). Using EU-SILC microdata, the project analyses the interactions between social vulnerability and different individual characteristics that might magnify it. Secondly, the project intends to study how, and in what ways, these individual characteristics combine to determine economic insecurity at household level. The main contribution of this project is proposing an analysis of how the institutional context as well as individual characteristics affects individual risk of living in vulnerable households, from a comparative and multidimensional perspective. By comparing six European countries, as representatives of different institutional environments, the VINE project aims to deliver a better understanding of the causes and mechanisms that determine both men and women’s exposure to social vulnerability. The innovation herein is the assumption that gender is the main analytical dimension in interactions, when theorised according to the intersectional perspective. With a multi-dimensional explorative analysis, and multinomial logistic regression, the analysis will lead to the development of a synthetic indicator of economic insecurity at the household level, permitting assessment of its interactions with specific individual vulnerability profiles. The final aim is to disentangle factors informing individual’s exposure to different degrees of social vulnerability, analysing their consequences and household’s economic insecurity, and possible influences from the institutional context. Thanks to this project, the ER will fill her gap in quantitative research analysis and she will be able to empower her professional profile compete for tenure-track position in the international academic labour market.

Keywords: social vulnerability,intersectionality,gender
Investigating the mechanisms that shape galaxies in and around massive clusters (ClusterGal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

For decades, astronomers have known that some galaxies are living in dense associations known as “galaxy clusters”, and that many of their properties, e.g. their morphology, colour, and gas content, differ from those of galaxies living in more isolated parts of the Universe (like our Milky Way). However, understanding the physical origin of these differences has so far proved elusive, constituting a major gap in our understanding of galaxy formation. My proposed research will deliver ground-breaking new insight into this long-standing problem, based on detailed analyses of a tailor-made set of hydrodynamical cosmological simulations - the “Hydrangea” suite - that has been completed under my leadership during the last two years. Specifically, I will investigate 1.) the transformation of spiral discs into elliptical galaxies; 2.) the processes by which gas is accreted in the far outskirts of clusters; 3.) the stripping of gas from galaxies and the resulting quenching of star formation after infall into the cluster. Furthermore, I will use the insight gained in addressing these questions to improve simulation codes beyond the current state of the art, in preparation for even more accurate future simulations. This research has become possible only now, as a result of successful efforts to improve and calibrate simulation codes so that they produce realistic galaxies, computers becoming powerful enough for large simulations like Hydrangea, and the availability of multi-epoch, multi-wavelength observational data sets to test the validity of the simulations in detail. The combination of my experience in simulation analysis and the world-leading expertise at my host, Leiden Observatory, in the development of simulation models and observations of the real Universe, provide the ideal setting to make this project a success and equip me with the skills required to lead independent academic research.
A.dditive MA.nufacturing for T.iltrotor HO.using (AMATHO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Switzerland
Call: Development and validation of an optimised gearbox housing structural design and manufacturing process, based on additive layer manufacturing concept leading to a flight cleared demonstrator. (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-12-01
End date: 2022-08-31
Duration (months): 69.0
Total project cost (EUR): 3321160.0
EU funding (EUR): 1749999.5
Participants: 3
Project status: SIGNED

AMATHO (A.dditive MA.nufacturing T.iltrotor HO.using) is aimed to design, assess and manufacture a novel tiltrotor drive system housing exploiting the features of additive manufacturing techniques. Preliminarily, functional, structural and technological peculiarities of rotorcraft main gearbox housings are analysed and relevant requirements are issued. In the meantime, viable AM processes are reviewed, on the basis of specific suitability, technological potential and degree of maturity. In particular, powder feed direct energy deposition techniques (Direct Laser Deposition - DLD) and powder bed fusion techniques (Selective Laser Melting - SLM and Electron Beam Meelting - EBM) are considered. The powder precursors are investigated as well, in terms of chemical nature (magnesium, aluminium, titanium alloy, stainless steel), particles granulometry and morphology. Static, fatigue, fracture mechanics, damage tolerance, corrosion endurance, chemical compatibility, machinability, weldability and heat-treatability testing are worked out and final trade-off process accomplished for choosing optimal materials and processes. Characterisation methodologies and NDI techniques are assessed as well. In addition to test activity on dedicated specimens, smaller, but fully representative, full-scale gearbox housing components (to be considered as proof of concept) are manufactured through the traded-off technologies and tested to check the compliance with general functional aspects of r/c drive system housing. In parallel, design rules and methodologies for detail design, optimisation and structural substantiation of AM components are defined and supporting numerical tools are set-up. Full-scale housing is manufactured and structural and functional tests are performed to support flight clearance on the NextGenCTR Demonstrator and procedures (engineering cost and industrial capability assessment) for the start-up of high-volume production are defined

Keywords: additive manufacturing,tiltrotor,monolithic housing,helicopter drive system,mechatronic,real time control,metal powder,testing,3d vision,welding,laser
Researcher's Night 2016-2017 in Estonia (RNEst16-17)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Estonia,Estonia,Estonia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-06-01
End date: 2017-11-30
Duration (months): 18.0
Total project cost (EUR): 177250.0
EU funding (EUR): 164000.0
Participants: 3
Project status: CLOSED

The main aim of the Estonian Researchers’ Nights 2016-2017 (RNEst16-17) is to highlight the most recent and important accomplishments of Estonian researchers and scientists. The Researchers’ Night also aims to encourage young people to choose careers in research, engineering and STEM-related areas, and to introduce these professions through numerous entertaining hands-on activities. The topic of RNEst16 is pointing out the links between scientific discoveries and the creation of plausible fictional scenarios. Events of RNEst16 involve talking about science as a creative process, the limits of science, interplay of literature and film. Wide range of subtopics, include time travel, wormholes, teleportation, extra-terrestrial intelligence, artificial intelligence, synthetic biology, genetic engineering, developing nanotechnologies, consciousness and mind manipulation etc. The theme of RNEst17 is ethics and responsibility in science and research. The focus is on elaborating on the topic of responsibility in research and ethical aspects of the present and future innovations. Events of RNEst17 involve talking about collaboration between society and researchers, citizen science, crowdsourcing, stereotypes in research field, how research and innovation take place within our society, how everybody should have a voice in science issues, ethical and socially acceptable innovation etc. To stress the importance of collaboration in the pan-European Researchers’ Night, joint events are going to take place in cooperation with other Researchers’ Night organisers from across Europe. Special events in English and Russian are also being held, most notably science cafes, workshops and science shows.

Keywords: researcher s night,science,ahhaa,science fiction,ethics,stem,science communication,innovation,public engagement
TowaRd market-based skills for sustAINable Energy Efficient construction (TRAINEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,North Macedonia
Call: Construction skills (H2020-EE-2017-CSA-PPI, 2017)
Start date: 2018-05-01
End date: 2020-10-31
Duration (months): 30.0
Total project cost (EUR): 877006.25
EU funding (EUR): 877006.25
Participants: 6
Project status: CLOSED

The overall objective is to increase the number of skilled building professionals according to recommendations from national qualification roadmap concerning two priorities, training of 4.500 building professionals and blue collar workers and overcoming barriers for implementation of EE measures in operation and maintenance. Specific objectives (SO) are -Upgrading two qualification schemes for technicians, building managers and engineers and development of large scale of training schemes for 5 blue collar qualifications and two RES occupations (designers and installers) by establishing the Knowledge Centre for support in development of sustainable EE market-based construction skills with annual capacity to replicate it to 10 training providers and 600 qualified construction workers (200 through training and 400 through recognition of previous learning): -Increasing awareness of building professionals for use of Building Information Modeling (BIM) tools, in order to achieve the desired multidisciplinary approach in construction that should result with reduction in the gap between designed and actual energy performance through improved quality of construction in specific projects and to achieve measurable energy savings and improved quality of indoor environment; -Improved market recognition of skills in the building sector and enhancing collaboration across different professional groups.

Keywords: vocational training,developed voluntary qualification schemes vqs
Molecular mechanisms regulating cardiovascular remodeling by Adamts1 (MERC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2019-11-15
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1+/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aortic disease. They have also found that nitric oxide synthase (NOS) inhibitors reverse aortic dilation and medial degeneration in Marfan mice and Adamts1-deficient mice. The objective of my project is to study the molecular mechanisms mediating these aortic diseases in mice, and to specifically assess the role of nitric oxide (NO) and related signaling pathways, including those of Adamts1 and its substrates, in the medial degeneration and aortic dilation in both mouse models. I plan to identify potential targets common to both aortopathies and analyze them in patients with syndromic and non-syndromic aortic diseases. I think this project has a strong potential to identify therapeutic targets and prognostic or diagnostic markers for human cardiovascular diseases that constitute one of the major causes of mortality worldwide.

Keywords: adamts1,molecular regulation of vascular remodeling,nitric oxide synthase nos,aorta,signaling
Energy balancing and resilience solutions to unlock the flexibility and increase market options for distribution grid (ebalance-plus)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Spain,Poland,Türkiye,Greece,France,Denmark,Portugal,Denmark,United Kingdom
Call: Flexibility and retail market options for the distribution grid (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 9481533.75
EU funding (EUR): 7999082.25
Participants: 16
Project status: SIGNED

The ebalance+ project applies to the ‘Flexibility and retail market options for the distribution grid’ by addressing flexibility solutions, smart-grids technologies to increase the distribution grid resilience and defining and testing market mechanisms and tools incentivising the energy flexibility. In this context, the ebalance+ project aims to increase energy flexibility of distribution grids, predict available flexibility, increase distribution grid resilience and design and test new ancillary models to promote new markets based on energy flexibility. These objectives allow unlocking the energy flexibility market in distribution grids to support energy prosumers and electric operators. The ebalance+ proposal is an ICT platform that assure the integration and interoperability at any electricity domain, providing an effective market framework where electric operators and stakeholders benefit with new business models. The system is composed of units that implements algorithms to forecast and manage the available flexibility to incentivise demand response programmes and increase the distribution grid capacity to avoid congestions and advise optimization strategies. Besides, it allows integrating the flexibility solutions (developed and tested in the project): electric storage, V2G systems, SiC power inverters, power to heat, control of CHP and management of building devices with IoT-based systems. Smart-gird automation and control solutions will be integrated to enhance the grid observability and use the available flexibility to increase the resilience under critical events. The consortium is composed of 15 entities from 8 EU countries, which the participation of research centres, SME and industry. The solutions are tested in 4 real-life pilots (Spain, Italy, France and Denmark) with specific scopes and objectives. In addition, and in-Lab demo is developed to test critical use cases. Innovative market models regarding flexibility market for DSO-TSO will be simulated

Keywords: grid resilience,grid flexibility,energy market,consumers engagement,prosumers,distributed energy resources,electric smart storage,smart grid