Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing the EFAS Smart Services Initiative to introduce a game -changer in the digital tachograph market (ESSI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Austria
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Truck transport is crucial for carrying European products from the production site or from ports to distributors and end consumers. By legislation drivers need to record their driving and rest times and those of the vehicle in EU and AETR countries. Since May 2006, all newly registered commercial vehicles > 3.5t carrying more than 9 persons are obliged to be equipped with a digital tachograph (reg. 561/2006). From June 2019 onwards, the so called "smart tachographs" are obligatory with enhanced obligatory technical features as per Annex 1C (reg. 165/2014). Despite high entry barriers Intellic managed to enter the high-growth market and is now one of only three worldwide suppliers of digital tachographs. But Intellic's EFAS Smart solution goes further than their global competitors Stoneridge or VDO: Intellic´s EFAS Smart solution integrates Software-as-a-Service cloud applications for industry 4.0 based on an Open Vehicle Platform with an Open Source strategy. So, in addition to the obligatory functions (abiding to national law like digital tachograph), EFAS Smart integrates key regulated functions and further optional functions developped by Intellic or 3rd party service providers. Our main target markets are OEMs for new registration of trucks and buses and After-market organizations for replacement and retrofitting. Intellic provides already EFAS versions to OEM production lines in Turkey and Russia. For the AMO market Intellic counts with an already established dealers network of 3.500 workshops all over Europe, Russia and Turkey. In 2020 the EFAS Smart Tachograph will be the central telematics device in the commercial vehicle sector in Europe. Intellic together with an up- and down-streamed partner network will be the innovation leader in the development of new "trusted services" in the field of logistics, fleet management and infrastructure optimization.

Keywords: tachograph,commercial vehicles,software as a service,industry 4 0
A Scalable Quantum Network based on Individual Erbium Ions (QuantumNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1477500.0
EU funding (EUR): 0.0
Participants: 2
Project status: SIGNED

A future quantum network will consist of quantum processors that are connected by quantum channels, just like conventional computers are wired up to form the Internet. In contrast to classical devices, however, the entanglement and non-local correlations available in a quantum-controlled system facilitate novel fundamental tests of quantum theory and numerous applications in distributed quantum information processing, quantum communication, and precision measurement. While pioneering experiments have demonstrated the entanglement of two quantum nodes separated by up to 1.3 km, accessing the full potential of quantum networks requires scaling of these prototypes to more nodes and larger distances. To this end, a new technology that overcomes the bottlenecks of existing physical systems has to be developed. Here, I propose to harness the exceptional properties of individual Erbium ions embedded in Yttrium crystals to increase the size of quantum networks via implementation of the seminal quantum repeater proposal, which is one of the most intensively pursued research topics in current quantum science. The key proposed steps to this goal are (I) implementation of a quantum spin-photon interface at a telecommunication wavelength, (II) multiplexing of many quantum bits in one device via frequency-selective addressing, and (III) implementation of remote entanglement swapping and purification to increase the range of quantum-secure communication beyond its current fundamental limit. These goals have been out of reach for any experimental platform until now. They become feasible by combining the powerful concepts developed in cavity quantum electrodynamics using cold atoms with the exceptional coherence of spins in specific host crystals. Successful implementation will demonstrate the feasibility of quantum networks over global distances, a milestone advancement for quantum communication and quantum science in general.

Keywords: quantum networks,quantum repeaters,spin based quantum information processing,cavity quantum electrodynamics,remote entanglement,quantum communication
Microfluidic bubble JET flow CELL sorter for cell therapy (JetCell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 149379.0
EU funding (EUR): 149379.0
Participants: 1
Project status: CLOSED

'T cell based cancer therapy has been recognized as one of the most promising future cancer therapy methods. In a typical T cell therapy course, relevant T cells are isolated from the patient’s blood, modified against certain cancer markers, and infused back into the patient’s body where the engineered T cells direct the immune system to attack and finally eliminate the malignant tumor cells and tissues. Recent clinical research demonstrated that purified T cell subsets could greatly improve the therapy efficacy. However, currently available T cell enrichment techniques including fluorescence activated cell sorting and immunomagnetic isolation are either too expensive and risky, or they lack the multi-marker support. Therefore, there is a need for safe, affordable and multi-marker based T cell enrichment methods for cell therapy applications. In ERC-SCALPEL project, we developed a thermal vapor bubble jet flow technique for high speed fluorescence cell sorting. The bubble jet flow sorter was based on a precisely fabricated metal heater in a silicon chip. A short current pulse applied to this metal heater induced an array of micro vapor bubbles and consequently a jet flow for high speed aerosol-free cell sorting at 4,000 cells/sec. The bubble jet sorter has shown promise to serve the cell therapy demand: high throughput, high flexibility, guaranteed biosafety and affordability. The JetCell project aims at carrying out a feasibility study of bubble jet sorting technology for the enrichment of T cells as the first step of a typical cell manufacturing process for cancer cell therapy. With a prototype setup, the bubble jet sorter will be assessed in typical pre-clinical cell manufacturing models, from human cell lines to primary blood cells. Meanwhile, the cell therapy manufacturing market will be further analyzed and an initial business development strategy will be investigated.

Keywords: cancer therapy,t cell isolation,t cell engineering,high speed cell sorting,cell manufacturing,microfluidic chip platform
Metacognition and bilingualism in linguistic and non-linguistic domains (MetaBil)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Over the last decades a great deal of studies have been done to explore the cognitive benefits of bilingualism, or to challenge the bilingual advantage in cognitive control. But almost nothing is known about the effect of bilingualism on metacognition, namely, the ability to monitor one’s own cognitive performance and the outcome of the cognitive processes across different task domains (linguistic and non-linguistic). Metacognitive processing may be influenced by the experience of a given individual in a specific domain. Consequently, bilinguals might display improved metacognitive awareness in tasks that are linguistic in nature. As they have more experience in linguistic tasks, error-detection and monitoring mechanism may be enhanced in bilinguals compared to monolinguals in these sort of tasks. Yet we still lack empirical evidence whether individual experience in language processing can also lead to enhanced metacognitive processing in linguistic domain, and whether it can be transferred to non-linguistic tasks. Building upon preliminary evidence presented in this proposal, this project will address for the first time how the bilingual experience and environment interact with metacognitive processing at both behavioral and neural levels. Within the framework of the proposed project, I plan to address the following questions: 1. How does bilingualism influence metacognitive sensitivity, efficiency and bias in performing linguistic and non-linguistic tasks in visual and auditory modalities? 2. Which brain circuits are involved in metacognitive processing in linguistic (as opposed to non-linguistic tasks), and how they are affected by bilingualism and environment? To address these issues, I propose a series of behavioral experiments followed by an fMRI study to define the brain networks and substrates involved into metacognitive processing, and to explore how individual differences in long-term experience affect these networks and modulate metacognitive processing.

Keywords: metacognition,confidence,decision making,bilingualism,bilingual environment
Massive MIMO Localization for 5G Networks (MassLOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Next-generation 5G wireless data networks promise significant gains in terms of offering the ability to accommodate more users at higher data rates with better reliability while consuming less power. To meet such a challenge, massive MIMO systems have been proposed to allow for orders of magnitude improvement in spectral and energy efficiency using relatively simple processing. The basic idea is equipping cellular base stations with rectangular arrays, each of them is consisted of very large number of antennas. The extra antennas help focusing energy into ever smaller regions of space to bring huge improvements in throughput and radiated energy efficiency. Other benefits include reduced latency, simplification of the media access control layer, and robustness against intentional jamming. An unexplored and unintentional side-effect of using a very large number of antennas combined with high carrier frequencies, is the ability to pinpoint the location of the user with high accuracy. This project aims to develop several analytical tools in order to model, design, and analyze massive MIMO-OFDM systems from the localization point of view, and ascertain their validity via experimental datasets. Ultimately, our broad goal is to conceptualize an engineering research idea, and then transition it into innovative applications that can be replicated for real-world cellular networks operated by established service providers and mobile manufacturers. In parallel, the project will allow the fellow to achieve several knowledge transfer objectives and increase prominence in his research field.

Keywords: 5g networks,positioning,massive mimo
Computational Design of Novel Functional Proteins for Immunoengineering (DeNovoImmunoDesign)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-12-31
Duration (months): 70.0
Total project cost (EUR): 1695489.0
EU funding (EUR): 1695489.0
Participants: 1
Project status: CLOSED

Finely orchestrated protein activities are at the heart of the most fundamental cellular processes. The rational and structure-based design of novel functional proteins holds the promise to revolutionize many important aspects in biology, medicine and biotechnology. Computational protein design has led the way on rational protein engineering, however many of these designed proteins were solely focused on structural accuracy and completely impaired of function. DeNovoImmunoDesign proposes novel computational design strategies centered on the exploration of de novo protein topologies and the use of structural flexibility with the ultimate goal of designing functional proteins. The proposed methodologies aim to solve a prevalent problem in computational design that relates to the lack of optimal design templates for the optimization of function. By expanding beyond the known protein structural space, our approaches represent new paradigms on the design of de novo functional proteins. DeNovoImmunoDesign will leverage our new methodologies to design functional proteins with rational approaches for two crucial biomedical endeavors - vaccine design and cancer immunotherapy. Our strategy for vaccine design is to engineer structure-based epitope-focused immunogens to elicit potent neutralizing antibodies – a requirement for vaccine protection. The underlying basis of cancer immunotherapy is the inhibition of key protein-protein interactions - an arena where rational design is lagging. To meet this central need we will develop innovative approaches to design new protein binders for cancer immunotherapy applications. DeNovoImmunoDesign is a multidisciplinary proposal where computation is intertwined with experimentation (biochemistry, structural biology and immunology). Our unique competences and groundbreaking research have all the components to translate into transformative advances for both basic and applied biology through innovations in rational protein design.

Keywords: structure based computational design,protein engineering,vaccine design,de novo design
Bidirectional Hyper-Connected Neural System (EXTEND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Iceland,Spain,Spain,Germany,United States,United Kingdom
Call: Interfaces for accessibility (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3143851.25
EU funding (EUR): 2943811.25
Participants: 9
Project status: CLOSED

Current brain and neural interfacing technologies still face significant limitations to become accessibility tools that can benefit people. On the one hand, non-invasive neural interface technology (e.g. EEG, EMG) is intrinsically unidirectional and of limited capacity. On the other hand, invasive technology (e.g. percutaneous EMG, implanted nerve electrodes or intracranial electroencephalography) while allowing two-directionality and better performance still relies on complex surgical procedures. EXTEND aims at developing the novel concept of Bidirectional Hyper-Connected Neural Systems (BHNS) to extend the capabilities of neural interfaces with minimally invasive communication links between multiple nerves in the body and multiple external devices. EXTEND will realise BHNS by developing disruptive wireless neuromuscular (injectable) interface technology that enables distributed stimulation, sensing, processing and analysis of neuromuscular activity, the ultimate stance of the neural code of movement. The EXTEND project will showcase the advantages of this new technology in two applications: (1) tremor management in essential tremor (ET) and Parkinson disease (PD), and (2) neural interfaced assistive wearable robots for spinal cord injury (SCI). EXTEND will also work towards a community hub that brings together stakeholders to create an innovation ecosystem that can nurture the fast development of neural interfaces around the new concept.

Keywords: implantable neural interface,neural recording,neural stimulation,bnci
Making container shipping more sustainable and efficient through digital technologies and data science (Next Gen Bluetech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2020-02-29
Duration (months): 21.0
Total project cost (EUR): 2032250.0
EU funding (EUR): 1422575.0
Participants: 1
Project status: CLOSED

Portchain is a company of data scientists, software engineers, shipping professionals and management consultants founded in 2017 to realize the huge digitization potential in global container shipping and help create a greener, more efficient industry. Our solutions use advanced analytics of operational data and next generation web technologies to optimize key planning processes in the shipping value chain. For example, we can improve the utilization of a typical container terminal by +5% and increase the speed and accuracy of multi-stakeholder port call coordination. The end result is significant bottom line impact for carriers and terminal operators and a potential annual saving of 15 million tonnes of CO2 emissions. Portchain is already used by carriers and terminals in live planning operations in one of Europe’s largest ports, but the vision is to connect the leading European ports in a regional cluster. The 18-month Horizon 2020 project supports the testing and replication of the solution across the continent and beyond. The development of Portchain was funded by the Danish Innovation Fund and the Danish Maritime Fund.

Keywords: data science,digital,container shipping,emissions,sustainable,value creation,intelligent solutions
Molecular Motors, powering dynamic functional molecular systems (MMDYNASYS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 2499524.0
EU funding (EUR): 2499524.0
Participants: 1
Project status: SIGNED

In this proposal the unique properties of unidirectional light driven molecular rotary motors will be built upon to achieve dynamic control of function and develop responsive systems with a particular focus on systems in water. Light-driven molecular rotary motors are distinct from the majority of molecular switches, as they allow sequential access to multiple functional states in a responsive system through non-invasive stimulation. Importantly, continuous irradiation induces continuous rotary motion which provides a unique opportunity to design dynamic systems and responsive materials that can be driven out-of-equilibrium. The research program is divided in four work-packages: a) chemical and redox driven unidirectional motors; here we will develop processive unidirectional motors that can use (electro)chemical energy in a continuous manner, b) amplification of motion; here rotary motors operate in assemblies to amplify mechanical function over a wide range of length scales. Specifically we will use liquid crystal-water interfaces as a unique platform to control motion and organization. c) dissipative self-assembly: molecular motors offer fantastic opportunities to control self-assembly and drive such systems out-of-equilibrium. We aim at metastable aggregate formation (hydrogels) and the design of amphiphilic motors for responsive self-assembled nanostructures; d)triggering biomolecular function; the goal is to use rotary motors to regulate DNA transcription and ultimately as genuine powering device to control cardiac cell function. In the emerging field of photopharmacology, we take advantage of non-invasive high spatio-temporal control that switching with light provides. The proposed research program is highly challenging but provides the comprehensive effort required to achieve control of complex nanomechanical systems and will opening a bright future for applications ranging from stimuli responsive materials to spatio-temporal control of biomolecular systems

Keywords: photochemistry,molecular motor