Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrophobic Eutectic Solvents for Tailored Metal Separation and Recycling (DESignSX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1499851.0
EU funding (EUR): 1499851.0
Participants: 1
Project status: SIGNED

DESignSX proposes the application of bio-inspired non-ionic hydrophobic eutectic solvents (DES) to the solvent extraction (SX) separation of lanthanides (Ln) based on the understanding of these complex mixtures that are defined by hydrogen-bonded supramolecular self-assembly. Sustainable metallurgy stands uniquely poised to reduce the environmental impact of existing processes whilst recovering the metal value in end-of-life devices, thereby closing the resource loop. Despite their growing demand and geopolitical criticality, Ln separation remains technologically challenging due to the small monotonic variation in their properties, negatively affecting the economics of their recycling. DESignX seeks to exacerbate the steric factors defining the interactions between Ln and ligands, dictating the ensuing complex geometries and mutual separation selectivity, through the inclusion of complexing agents as components of molecularly crowded DES. By carefully selecting the DES phase binary components, the energy penalty associated with the structuration of the apolar phase may be rationally adjusted to increase the selectivity between adjacent Ln versus the same extractant in conventional SX. Given that the separation of adjacent Ln occurs over dozens of counter-current extraction stages, even seemingly small increases in the separation factors yield measurable environmental and economic gains. DESignSX rely on a tandem experimental-computational approach spanning multiple time and size scales, from a molecular description of pair-wise interactions to laboratory-scale process optimisation. DESignSX will overcome the traditional SX issues of complex flowsheets, third-phase formation, toxicity of the organic diluent through the inclusion of bio-derived components, and entrainment losses, whilst improving the selectivity of the separation. DESignSX outcomes are expected to be transferable to other critical SX separations.

Keywords: hydrometallurgy solvent extraction lanthanide separation deep eutectic solvents circular economy
Unraveling mechanisms of drug resistance: APOBEC3A as a genomic and post-transcriptional driver of treatment resistance in pancreatic cancer (ADRIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1880615.0
EU funding (EUR): 1880615.0
Participants: 1
Project status: SIGNED

Pancreatic cancer is predicted to become the third leading cause of cancer-related death in Europe. Drug resistance to even the most effective anti-cancer-targeted therapies constitutes a major contributor to poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Kirsten rat sarcoma virus (KRAS) mutations are found in >90% of PDAC, being an important oncogenic driver. Although KRAS-targeted therapies have the potential to transform the clinical management of PDAC drastically, only a subset of patients respond, and resistance is frequent. The extent to which genomic and post-translational processes drive drug resistance remains largely unknown. Genomic analyses have identified the APOBEC family as a key driver of mutagenesis in cancer, including PDAC. Among family members, APOBEC3A (A3A) is involved in genomic alteration and post-transcriptional RNA editing, both mechanisms causative for intra-tumoral heterogeneity (ITH) and drug resistance. My preliminary data reveal that A3A induces chromosomal instability and likely ITH. In addition, I found that A3A-mediated RNA editing is prevalent in human PDACs and a mouse model for A3A. Importantly, I observed that A3A expression increases during KrasG12D targeted therapy, reduces sensitivity, and facilitates clonal outgrowth, and thus, is likely to drive drug resistance in PDAC. The ADRIP study will utilize murine and human models for A3A, to unravel for the first time whether A3A plays a dominant role in increasing ITH in PDAC (Aim1). Second, it will elucidate whether A3A-mediated genomic or post-translational modifications (Aim2) drive pre-existing and acquired KRAS inhibitor resistance. Applying a multi-omics approach, the ADRIP study aims to identify novel regulators of A3A that could serve as therapeutic targets (Aim3). Importantly, the ADRIP study may have direct clinical implications as the basis for future pre-clinical/clinical intervention trials that target A3A to prevent drug resistance in KRAS mutant cancers.

Keywords: kras inhibitor drug resistance,rna editing,tumor heterogeneity,genomic alterations,mutagenesis,mouse models
Enabling Innovative Space-driven Services for Energy Efficient Buildings and Climate Resilient Cities (BUILDSPACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: Greece,United Kingdom,Belgium,France,Poland,Slovenia,Latvia,Spain
Call: EGNSS and Copernicus applications fostering the European Green deal (HORIZON-EUSPA-2021-SPACE, 2021)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2968525.0
EU funding (EUR): 2632367.5
Participants: 14
Project status: SIGNED

BUILDSPACE aims to couple terrestrial data from buildings (collected by IoT platforms, BIM solutions and other) with aerial imaging from drones equipped with thermal cameras and location annotated data from satellite services (i.e., EGNSS and Copernicus) to deliver innovative services for the building and urban stakeholders and support informed decision making towards energy-efficient buildings and climate resilient cities. The platform will allow integration of these heterogeneous data and will offer services at building scale, enabling the generation of high fidelity multi-modal digital twins and at city scale providing decision support services for energy demand prediction, urban heat and urban flood analysis. The services will enable the identification of environmental hotspots that increase pressure to local city ecosystems and raise probability for natural disasters (such as flooding) and will issue alerts and recommendations for action to local governments and regions (such as the support of policies for building renovation in specific vulnerable areas). BUILDSPACE services will be validated and assessed in four European cities with different climate profiles. The digital twin services at building level will be tested during the construction of a new building in Poland, and the city services validating the link to digital twin of buildings will be tested in 3 cities (Piraeus, Riga, Ljubljana) across EU. BUILDSPACE will create a set of replication guidelines and blueprints for the adoption of the proposed applications in building resilient cities at large.

Keywords: digital twin,bim,iot,egnss,copernicus,blue green infrastructure
PHONONIC CIRCUITS WITH NONLINEAR NANOMECHANICAL OSCILLATORS (PIONEER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal,Finland,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 3
Project status: SIGNED

Phononic integrated circuits (PnICs) have significant potential in information and communication technology (ICT), with a key challenge being the reduction of phonon transmission losses. Energy or information propagation without losses, as predicted by the Fermi-Pasta-Ulam-Tsingou Recurrence (FPUT-R), has not yet been experimentally demonstrated in nanomechanical oscillators due to three key challenges: the dominance of linear interactions in PnICs, sensitivity to dissipation, and the difficulty of measuring small displacements necessary for FPUT-R analysis. To address these challenges, PIONEER will leverage recent advancements in nonlinear phononic resonators and nanophononic crystal structures. Building on the applicant’s theoretical predictions and the cutting-edge nanotechnology available at the host institution, PIONEER will design, construct, and test FPUT-R in phononic circuits using nonlinear nanomechanical oscillators. The project is driven by the EU's urgent need to reduce energy consumption in ICT and nanoelectronics for energy-efficient smart edge devices, while also aligning with the goals of shaping Europe’s Digital Future. PIONEER represents an extraordinary training opportunity on complementary scientific and soft skills for the applicant and has the potential to enable phononic and photonic integrated energy-efficient smart edge devices for optical data processing, quantum technologies, and Shaping Europe’s digital future and beyond.

Keywords: nanophononic crystals,fermi pasta ulam tsingou recurrence,nonlinear coupled resonators
Old Books, New Worlds: Early Modern English Printed Drama in Australia and New Zealand (EMPDANZ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Australia,New Zealand
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 3
Project status: SIGNED

The proposed research project has a two-pronged aim. Firstly, it examines copies of sixteenth- and seventeenth-century playbooks held in Australian and New Zealand libraries in order to bring a transnational framing to the reception history of the culturally influential literary genre of early modern English drama. Secondly, it examines how data relating to these copies can be presented to the international scientific community in a way that foregrounds these copies’ specific geographic and political contexts, in line with approaches to the decolonisation of knowledge that reflect the books’ Southern Hemisphere settler colonial locations. Scholars in the field of book history are beginning to confront this field’s reliance on material artefacts (i.e. rare books) that were acquired and preserved with the aid of wealth obtained in problematic circumstances, but thus far the focus of such confrontations has been Northern Hemisphere copies and collections. In creating outputs focused instead on data drawn from inspections of Southern Hemisphere collections of rare books, and in developing an online resource that provides an international model for how to acknowledge problematic acquisition histories in culturally sensitive ways, “Old Books, New Worlds: Early Modern English Printed Drama in Australia and New Zealand” offers a significant and transformative intervention in the field of book history. It is relevant both to the 2023-2024 Work Programme to produce “Innovative research on the European cultural heritage and the cultural and creative industries – building our future from our past” and also to the 2023-2024 Work Programme to facilitate “A human-centred and ethical development of digital technologies”.

Keywords: book history,early modern drama,digital humanities,australia,new zealand,settler colonial history,decolonisation,critical bibliography,critical archival studies,critical librarianship
STRATOSPHERIC BALLOON-BASED LASER ABLATION SYSTEM FOR SPACE DEBRIS REMOVAL (STRATOLASER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,United Kingdom,Czechia,Germany,Italy
Call: Strengthening the sustainability and resilience of EU space infrastructure (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 4569059.29
EU funding (EUR): 3996754.0
Participants: 7
Project status: SIGNED

STRATOLASER aims to strengthen the protection of EU space infrastructure by developing a breakthrough, cost-effective active debris removal system based on the de-orbiting of space debris ranging from a few centimeters to several tens of centimeters in size, using direct laser ablation technology fired from a stratospheric balloon. By eliminating atmospheric attenuation and scattering of the laser beam, the system drastically reduces the laser's power requirements, while offering a much lower cost, maintenance capacity, greater versatility, and wider orbital access compared to spaceborne solutions. This project will conduct the first experimental campaign to demonstrate proof-of-concept for stratospheric laser-ablative debris removal, achieving TRL 4 and establishing foundational technology. Using two stratospheric balloons—one with a debris fragment and the other with a small-scale pulsed laser and relay mirrors—experiments will monitor ablation under varied distances. Additional tests will involve laser scanning on orbital debris, focusing on signal return without reaching the ablation threshold due to power constraints. Complementary lab work will optimize the laser for stratospheric conditions, enhance UV conversion, and explore scalability. Mission analysis will evaluate post-ablation trajectories, aiming for a €2.5K cost per debris object removed.

Keywords: laser ablation,stratospheric balloon
Democracy dies in darkness without Official Data. (DEMSTAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Malta,Lithuania,Chile
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 201764.4
EU funding (EUR): 201764.4
Participants: 3
Project status: SIGNED

My main ambitious is to put at the centre of the debate the Official Statistics in Democracy for Policy-Makers, Researchers and all the citizens. In my experience, I noticed that at times also within the National Statistics Offices (NSOs) they do not know the importance that NSO has for democracy and policy-makers. Democracy dies in darkness without Official Data. Official Statistics is a public good, it is vital for democracy. I want to analyze the empirical and theoretical relation between Official Statistics and Democracy and formalize ten new variables that Official Statistics should produce and disseminate to improve society, economy and the relationship among countries. A key word in my project is the word: ‘multidisciplinary’. Those disciplines are, among others, Statistics, Economics and Political Science. The relation between democracy and Official Statistics is an almost unexplored scientific topic with economical and societal worldwide impact. Media and policy-makers use the official data everyday, because National Statistics Offices (NSOs) are in every single country. The official statistics are produced and disseminated by the NSO. Every day, we listen to the news about the employment rate, the GDP, mortality rate, car accidents, etc. All these statistics are collected, produced and then disseminated by the NSOs around the world. Also, COVID data should be produced and disseminated by NSOs as I explained in one of the top journals on Official Statistics, see Di Gennaro (2020) . Can we organize political elections without an independent and trustable official data produced and disseminated by the National Official Statistics Offices? For instance, trustable data on employment rate and national economic growth (Gross Domestic Product, GDP) are critical for the voters that want to evaluate the government. My research is in line with the value of the European Union and United Nations, and the Sustainable Development Goals.

Keywords: official statistics,democracy,national statistic office,sustainable development goal,european union values
Ion Mobility Mass Spectrometry Training Network (MobiliTraIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,France,Switzerland,United States,Belgium,United Kingdom,Sweden
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2828558.06
EU funding (EUR): 2716898.4
Participants: 23
Project status: SIGNED

Ion mobility-high resolution mass spectrometry (IM-HRMS) is the next-generation analytical platform in research and industry. Unlocking its full potential across applications as varied as biotherapeutics, environment and food safety requires not only pushing back the frontiers of instrumentation, fundamental understanding and applications – but harmonisation is essential. To achieve this, current shortcomings in data collection, analysis and reporting across instrument types, laboratories and research areas need to be scrutinised and overcome. The MobiliTraIN Doctoral Network will form 13 Doctoral Candidates (DCs) who will bring a new fundamental understanding of IM-HRMS, provide reference materials and guidelines for standardisation, develop state-of-the-art methods for the application of IM-HRMS in biopharmaceutical development, biological ‘omics studies, and nontarget screening of contaminants, and lay the foundations for IM-HRMS adoption in industry. Through an interdisciplinary research programme, including an open science approach and training in technical, business and transferable skills, the MobiliTraIN DCs will become leading experts in ion mobility with a unique skill set to successfully advance their careers while supporting Europe’s innovation capacity. Building on existing collaborations and research excellence covering the entire innovation chain of IM-HRMS development and application, MobiliTraIN unites 10 academic institutions, 3 leading instrumentation companies, 1 regulatory agency, 1 pharma industry leader and 5 SMEs from 8 countries. With complementary expertise, know-how and mentoring experience, our consortium is ideally suited to unveil the potential of IM-HRMS as a key technology for safer therapeutics, better understanding of complex disease progression and improved monitoring of food, water and public health safety.

Keywords: biotherapeutics,collision cross section ccs,mass spectrometry,ion mobility,ion mobility mass spectrometry,lipidomics,metrology,molecular structure,nontarget contaminant screening,proteomic
Small Area Estimation Methods to Monitor the Progress towards the Sustainable Development Goals at the Subnational Level in the European Union (SAESDGs-EU) (SAESDGs-EU)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499841.0
EU funding (EUR): 1499841.0
Participants: 1
Project status: SIGNED

The United Nations (UN) General Assembly highlights the need to disaggregate Sustainable Development Goals (SDGs) indicators by different socio-economic characteristics e.g., income, sex, age, race, ethnicity, migratory status, disability, and small geographic location, or other relevant characteristics (General Assembly resolution 68/261). However, large scale national sample surveys, i.e., the EU Statistics on Income and Leaving Conditions (EUSILC), which collect variables that are needed to produce such indicators, are not designed to be reliable at those disaggregation levels. Small area estimation (SAE) methods are thus needed to produce accurate and precise estimates at a subnational level. SAE methods combine different auxiliary data sources (e.g., the Census with survey data), thus ‘borrowing strength’ from related areas to make a better-quality small area estimates. The focus of SAESDGs-EU is on economic well-being, which is closely related to the SDGs, as improving quality of life is a core objective of sustainable development. Many of the 17 SDGs explicitly target well-being by addressing economic, social, and environmental factors. Economic well-being is multidimensional, hence a variety of indicators should be considered when measuring it. In this project, we will develop a single-step method to produce small area composite indicators of economic well-being based on the EUSILC. This is a ground-breaking innovation, since currently first composite indicators are produced and then SAE methods are applied (or vice-versa), in a two-step approach. The literature has highlighted problems with this approach which impact the data quality of the final estimates. Given that SAE requires auxiliary information, we will also explore pitfalls and potentials of using non-traditional data sources as auxiliary information (e.g., web-data, satellite data). These are well known data sources that provide granular spatial information.

Keywords: survey methodology,survey statistics,small area estimation,well being,composite indicators