Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A circular economy approach for lifecycles of products and services (CIRC4Life)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Spain,Spain,Belgium,Finland,Greece,Poland,Sweden,Sweden,United Kingdom,United Kingdom,United Kingdom
Call: Systemic, eco-innovative approaches for the circular economy: large-scale demonstration projects (H2020-CIRC-2017TwoStage, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 7228773.75
EU funding (EUR): 6294033.39
Participants: 17
Project status: CLOSED

This project aims to develop and implement a circular economy approach for sustainable products and services through their value and supply chains. Three new circular economy business models will be developed including (i) co-creation of products and services, (ii) sustainable consumption, and (iii) collaborative recycling and reuse. The Co-creation of Products/Services model will bring end-users closer to the design and manufacturing phases by identifying consumer preferences via Big-data online mining product reviews and evaluating product specifications and prototypes via Living Lab to customise the end-user requirements. Benefited from the co-creation features, sets of sustainable production methods will be implemented and new products/services will be created. The Sustainable Consumption model will develop a method to calculate the eco-points of products based on the outcome of FP7 myEcoCost project, assess product environment footprints (PEF), provide a traceability solution to monitor product’s sustainability along the value chain, and support end-users and stakeholders to actively implement the circular economy via awareness raising and knowledge sharing activities. The Collaborative Recycling/Reuse model will develop a system for stakeholders to interact with each other to facilitate the use/reuse of end-of-life products and reduce waste, and implement the eco-credits awarding scheme to encourage people to recycle/reuse. This project will be demonstrated at a large scale in electrical and electronic products and farming/agri-foods sectors, provide an effective means to communicate with wide communities to disseminate the project outcome, and involve a large number of stakeholders along value and supply chains throughout the project lifetime, including end-users, producers, researchers and civil society. An ICT platform will be developed to support the development, implementation, demonstration, communication and dissemination.
Oxide Nanoelectromechanical Systems for Ultrasensitive and Robust Sensing of Biomagnetic Fields (OXiNEMS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Sweden,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-05-01
End date: 2024-01-31
Duration (months): 57.0
Total project cost (EUR): 3176802.5
EU funding (EUR): 3176802.5
Participants: 6
Project status: SIGNED

In this project, we develop a new class of nanoelectromechanical systems (NEMS) based on integrated multifunctional oxides. With these devices, we will construct ultrasensitive and robust detectors for biomagnetism and apply them as transducers for applications in the field of human brain imaging. OXiNEMS will exploit advanced multifunctional materials, namely transition metal oxides (TMOs) to create new types of NEMS and MEMS devices based on crystalline heterostructures and revolutionize the field of M/NEMS across many areas of technology. As proof-of-concept of this innovative vision, OXiNEMS targets breakthrough research for developing nanomechanical sensors for measuring weak magnetic fields, in particular those found in Magnetoencephalography (MEG) and Ultralow-Field/Very-Low-Field (ULF/VLF) Magnetic Resonance Imaging (MRI). Presently available instruments are based on Low Temperature SQUID detectors which are extremely sensitive, but are mildly robust to static and pulsed magnetic fields, such as the ones used in ULF/VLF MRI and Transcranial Magnetic Stimulation (TMS), still not integrated with MEG. SQUIDs require expensive operation and maintenance costs, as they work in a liquid helium (4K) bath. OXiNEMS will develop robust magnetic field sensors based on nanomechanical resonators with all-optical readout, working in a simplified cryogenics setup at the liquid nitrogen temperature (77K). This allows for a much smaller working distance which enables biomagnetic detection with unprecedented spatial resolution. The success of OXiNEMS will thus both revolutionize the NEMS and MEMS field by introducing a new class of multifunctional sensors/actuators, and also it will open new directions in the field of human brain imaging by facing one of the most critical current challenges of neuroscience and the clinical community: to image brain activity and connectivity with high spatial and temporal resolution combining MEG with MRI and TMS on the same system.

Keywords: oxide electronics,mems,nems,optomechanics,magnetic field sensors,biomagnetism,thin,films,resonators,magnetoencephalography,ultra low field magnetic resonance imaging
Pine protection against Pitch canker through genetic resistance and plant immunization (PLIMPine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Pinus is one of the most ecologically and economically significant tree genera in the world having an extreme economic importance to wood and paper industries. Pine pitch canker, caused by the fungus Fusarium circinatum, is an introduced non-native pine disease in natural and planted stands of Europe subject to quarantine measures. To date, there are no suitable approaches available to control this threat, being associated with elevated economic losses to the forestry sector. “Plant immunization” or priming, is pointed as the safest and most effective biotechnological approach to boost the endogenous plant immune system. Phosphites (Phi) have been shown to activate plant resistance acting in a dual way, both at the host and fungus level. PlimPine project has been built on the basis of ecological, industrial and socioeconomic importance of European pine forests, combined with the fact that short research is conducted on F. circinatum in Europe. We propose a substantially cross-disciplinary (from physiology to Omics) and ambitious, but feasible, project to create knowledge and tools to explore the intricate defence system against pathogens for forest trees, having Pinus-Fusarium interaction as a model. This project aims to characterize and identify markers of resistance (natural or induced) to pitch canker disease based on solid and exciting preliminary results. Deciphering the mode of action of Phi will help in the preventive application as a viable alternative for the pitch canker management, contributing to the European forest management.

Keywords: pinus,pitch canker,plant immunization,system biology
Third Sector Involvement in Higher Education for Refugees - a Forum Theatre Approach (HEforR Forum)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

This project analyses access to and involvement in Higher Education (HE) for refugees via charitable organisations in Ireland and Germany. Based at Sutherland School of Law at University College Dublin for 24 months, under the supervision of Dr Oonagh Breen, I will compare the national legal framework for non-profit organisations (npos) to provide support for refugees in entering HE. The research is flanked by a secondment at the unit "Higher Education for Refugees" at DAAD in Bonn. I will improve interview skills, academic writing skills in English and project management skills via the fellowship which will allow me to take up a permanent and senior post at a HE institution within the ERA after the fellowship. The project follows an innovative methodology mix which has not been used before. Apart from the comparative legal study, the project uses a combination of problem-centred interviews (PCIs) and narrative interviews with refugees to collect and analyse data on how they were helped to access HE institutions via npos. The data analysis from the PCIs will lead to transcribing the data from the interviews to a script which is used as the basis for Forum Theatre. Forum Theatre provides the opportunity for the interviewees to interrupt and alter the play at any time to secure the validity of their narrative. The play will be shown publicly. Via the use of Forum Theatre, refugees will be able to provide their narrative of support, inclusion/exclusion, empowerment and agency and hence offer a counter narrative to our binary notions of refugees. There will be a strong focus on the gender aspect of refugee girls and women being excluded from higher education and the socio-political implications this has for participation and integration, and the future within ERA. The project will lead to a new approach in understanding the importance of access to tertiary education for refugees in the ERA and influence policy-makers, legislators and the private sector within ERA.

Keywords: forum theatre,refugees,higher education access,non profit organisations,agency,participation,bottom up approach,soft law,hard law,democratisation,collaborative partnerships,diversity
Chromosome-based mechanisms of transcriptional inactivation during mitosis (ChromoSilence)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 1
Project status: SIGNED

Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity. While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now. My lab has pioneered the use of acute perturbation approaches to dissect cellular process with unprecedented temporal resolution, which hold the prospect of surpassing current limitations on the identification and manipulation of multiple MTI layers. Using these novel approaches, ChromoSilence aims to test the hypothesis that MTI is a vital process for proper genome partitioning and transcriptional control. We will focus our analysis on chromosome-based events, that we propose as key contributors for MTI regulation, and test how classic chromosome assembly factors impact on mitotic transcriptional shutdown. In parallel, and supported by strong preliminary observations for a putative candidate, we will identify and reveal the function of novel players involved in chromosome-based mechanisms to drive MTI. New knowledge on the MTI mechanisms will be used to develop tools to uncover the role of this transcriptional shutdown in the fidelity of nuclear division and thereby identify novel routes to maintenance of genome stability. We will additionally uncover how the transcriptional silencing during mitosis may impact on maintenance of transcriptional programs in various developmental contexts. Collectively, ChromoSilence will reveal that MTI is not a by-product of passage through mitosis but instead an essential process for accurate chromosome segregation, maintenance of cell identity and organism development.

Keywords: mitosis,chromosome condensation,transcription,drosophila
War and the Supernatural in Early Modern Europe (War and Supernature)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-02-28
Duration (months): 60.0
Total project cost (EUR): 1324885.0
EU funding (EUR): 1324885.0
Participants: 1
Project status: CLOSED

The debates of intellectuals both Catholic and Protestant have much to tell us about the nature of religious warfare in early modern Europe. In the seventeenth century, the small numbers of radical Catholics and Protestants who favoured imposing their own version of Christianity on others by force were accused by moderates (no less religiously sincere) within their own communities of promoting wars incompatible with Christian orthodoxy. Religious faith, the moderates insisted, was a supernatural thing, a gift of God, rather than a natural thing, a creation of rational humans, and thus could not be imposed by force. Arguments for religious war in the sense of evangelisation by force were thus resisted by most of the educated European elite. These debates among university-based Catholic and Protestant intellectuals took place in the Latin language and are insufficiently known to political historians of early modern Europe. Political historians examining the phenomenon of early modern religious war impose the modern categories of sacred (which they associate with the irrational) and secular (which they posit must be drained of the divine) on the past, mistakenly assuming that those who opposed evangelisation by force were somehow more secular than their opponents and composing a false history of secularisation. This project will analyse, translate, edit, and publish these scholastic debates between religious militants and religious moderates on the role of force in religious life in order to inform and re-shape arguments among political historians on the nature of religious warfare. One focus of the project will be the Franciscan intellectual tradition which favoured evangelisation by force. But some Protestants and especially Calvinists also brought the supernatural very far into human life, and the project will insist on the utility of that distinction between natural and supernatural in composing a trans-confessional history of religious militancy.

Keywords: scholasticism,history of universities,religious and holy war,neo latin,franciscans,calvinists,sacred,secular,natural,supernatural
SANZ Telematics: Wireless Innovation for Smart Maintenance in Industrial Vehicles (SANZ Clima)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SANZ Telematics offers an opportunity to make more efficient urban transport, helping fleet managers to increase availability of their vehicles, reduce stock costs and manage maintenance parts in a faster and more accurate way. Having telematics data available wirelessly, bus manufacturers, transit agencies and maintenance enterprises can benefit from a real-time knowledge of the status of their units, planning in advance daily operations and services. Custumer satisfaction will be boosted due to the fact that probability of failure will be reduced. Preventive maintenance will be done in a precise way using custom and predictive algorithms through smart statistics. SANZ Clima Telematics reduces 75% of installation costs, 40% of stock control and working capital in purchasing parts and 50% of maintenance costs. The overall objective is to adapt our existing products to include sensors that will let us know the status of the units remotely, improve our current maintenance service and boost performance of Bus Systems in all of its life cycle. Moreover, we will include telematics in all of our transportation. In the feasibility study we will analyze the technical viability of the proposed solution tested in a prototype on its real environment (Public bus), study the patentability of the product and analyse the development of new software techniques related to a smart preventive maintenance, smart cities and Internet of Things.

Keywords: fleet management throught telematics,predictive and preventive maintenance,cost reduction,wireless data,smart statistics,customizable maintenance,modern industrial vehicles,internet of things
GPCR Exploitation To Unlock the Power of Brown/Beige Adipose Tissue (GET-UP BAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2018-08-31
Duration (months): 11.0
Total project cost (EUR): 149986.0
EU funding (EUR): 149986.0
Participants: 1
Project status: CLOSED

Hundreds of millions of people suffer from obesity and diabetes worldwide. These diseases diminish both life quality and expectancy and new treatment strategies are desperately needed. One possible approach is to target the calorie-burning and glucose-consuming functions of brown and beige adipose tissue (B/BAT). Previous attempts to harness the therapeutic potential of B/BAT have largely focused on the β-adrenergic class of G protein-coupled receptors (GCPRs). Unfortunately, these methods are hindered by adverse cardiovascular side effects linked to adrenergic activation. Therefore, uncovering non-adrenergic alternatives to exploit B/BAT for treating metabolic disease holds the potential for enormous societal and economic benefit. Here, we propose the activation of one such non-adrenergic GPCR on B/BAT as a means to treat obesity and diabetes. We identified this GPCR from a screen of B/BAT receptors performed in my ERC Starting Grant project, aCROBAT. We found that treating brown adipose cells with the peptide ligand for this GPCR increased oxygen consumption. We recognized the therapeutic potential after observing that ligand administration in vivo lowered bodyweight and improved insulin sensitivity in obese mice. However, the resources required to develop this discovery into a tangible innovation extend beyond the scope of aCROBAT. Consequently, I’m applying for an ERC PoC grant for critical support to take the initial steps to commercial application. Specifically, we seek to strengthen our IP position by developing patentable, longer-lived analogues of the ligand. Importantly, we will test these lead compounds head-to-head and in combination with current treatment options. We have assembled a team of experts to address key aspects from peptide design and pharmacology to IPR strategy and commercial development. Combined with our validated in vitro and in vivo testing platforms, we are ideally poised to maximize innovation potential.

Keywords: brown and beige adipose tissue,g protein coupled receptor,obesity and diabetes,peptide based therapeutics
ComFyt, the revolution in compression therapy. A novel Electro-Active Polymers technology applied to a smart stocking that mimics rhythmic calf muscle contractions and stimulates the blood flow. (ComFyt)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2020-06-30
Duration (months): 25.0
Total project cost (EUR): 1908775.0
EU funding (EUR): 1336142.5
Participants: 1
Project status: CLOSED

The innovation consists in the proprietary method and mechanism for maintaining the smart material- Electroactive Polymers (EAP) - in a pre-stretch state. This revolutionary technology manipulates the EAP film into thin, linear actuators, for integration in numerous healthcare devices. Highly suitable for wearable devices, the EAPs expand and contract when stimulated by an electric field. ComFyt - the first application of our innovation - is a smart stocking designed for venous disease patients. ComFyt can be worn throughout the day everywhere. It massages the leg mimicking calf muscle contractions and treating potentially life threatening circulatory conditions. Its agility and flexibility solves the problem of low compliance and comfort of the current compression therapy devices. Blood circulation is a crucial part of the human anatomy, ensuring nutrient and oxygen delivery to all the cells in the body. Poor circulation can cause painful VDs, such as edema, varicose veins, lymphedema, and multiple sports injuries, which greatly affect the patient’s quality of life. Life threatening disorders, such as Chronic Venous Insufficiency and Deep Vein Thrombosis (DVT) are serious conditions caused by compromised circulation too. Every year, approximately 10 million people suffer from DVT worldwide.

Keywords: medical device,venous diseases