Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoscale Analysis of Inter-Organelle Interactions and their Role in Neuronal Plasticity (ComOrganellesAnalyt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2499861.0
EU funding (EUR): 2499861.0
Participants: 1
Project status: SIGNED

Cellular communication is mediated by nanometer-sized organelles (vesicles, stress granules, exosomes) that are potentially responsible for carrying and releasing signalling molecules. I propose to use my extensive background in electroanalytical chemistry and mass spectrometry imaging to develop new technologies to chemically dissect vesicles, exosomes, and stress granules both dynamically and in fixed samples with spatial discrimination across living cells - the next frontier in cell analysis. The following four aims are proposed. I will develop 1) methods to chemically dissect and dynamically determine chemical species at and in nanometer organelles and suborganelles, 2) methods to spatially measure and evaluate the chemistry of organelles across cells, 3) analytical approaches to measure exchange of transmitters and metabolites between organelles and the role of this exchange in cellular communication, and 4) experiments in organoids and fly brain leading to a unified theory of the chemical interaction between organelles involved in cellular communication and plasticity. My group has pioneered the discovery that most regular exocytosis is partial, adding a third release mode to kiss n run or full vesicle distention. This opens a window of discovery concerning the structural and dynamical mechanisms of organelles that regulate neural communication. Ultimately, this will allow me to discern the chemical mechanisms of initial plasticity and brain cellular disease as it is likely that the different organelles in the cell related to communication interact chemically to regulate this process. This proposal is to develop and apply analytical methods to discover the interconnections between these organelles, and to relate them to the chemical events initiating plasticity.

Keywords: nano organelle analysis,amperometry,mass spectrometry imaging,sted super resolution microscopy
Green Engineering, Analysis, & Reskilling for Unbounded Production (GEAR-UP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Sweden,Norway,Spain,Germany,United Kingdom,France,Italy
Call: Technologies/solutions to support circularity for manufacturing (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 5999683.75
EU funding (EUR): 5999683.75
Participants: 13
Project status: SIGNED

The GEAR-UP proposal, is a comprehensive initiative to revolutionize the manufacturing sector through sustainable practices and advanced technologies. The project's central objective is to develop digital tools and methodologies that address recycled materials variability. It covers stainless steel, aluminum alloys, and fiber-reinforced plastics for additive manufacturing (AM). It employs simulation-driven approaches for optimizing various AM processes, including laser beam-directed energy deposition, metal laser beam powder bed fusion, and fiber-reinforced polymer material extrusion. GEAR-UP also emphasizes environmental conservation by using recycled materials in engineering design, significantly reducing virgin resources, energy consumption, and greenhouse gas emissions. The project intends to overcome challenges associated with secondary materials, such as performance variability, through resilient design and life-cycle environmental impact assessment. Moreover, the proposal outlines ambitious objectives for enhancing sustainable product design using innovative simulation and modeling software. It also implements the Digital Product Passport initiative and fosters human involvement in advancing circularity and sustainable technology adoption. This is done through training and global collaborative networks. GEAR-UP's approach represents a paradigm shift in engineering design, focusing on the circular value chain and developing universally adaptable AM technologies resilient to material variability. This endeavor is expected to directly impact the high-performance consumer products, green energy, & high-tech robotics markets. The key outcomes are: Cost savings: 25 % Increased productivity: 20-50 % Extended fatigue life: 50-80 % Defects reduced: 50-80 % Material waste reduced: 25-30 % CO2 emissions reduced: 25-50 % Reduced quality failures: 70-90 % Reduced design time: 20-50 % Reduced component weight: 25-30%

Keywords: circularity,explainable artificial intelligence,additive manufacturing
Smart Immune ProTcell: first-in-class allogeneic thymus empowered T cell therapy platform for fast and durable immune system reconstitution (Smart ProTcell)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-06-01
End date: 2025-11-30
Duration (months): 30.0
Total project cost (EUR): 3565625.0
EU funding (EUR): 2495937.5
Participants: 1
Project status: SUSPENDED

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in immunodeficiencies & blood malignancies though costly, hard-to-access & linked to many severe complications. Smart Immune puts forth a high-profile solution to solve this gap: ProTcell platform supplies clinical-grade, allogeneic lymphoid progenitor cells produced in just 7 days ex-vivo. These are made into tolerant polyclonal mature T cells by the patient’s own thymus in a record <3 months (vs. 15-24 months naturally), & reducing complications since infused in our 1st patient (June 2020). With strong IP, orphan drug label secured & traction across eminent KOLs in >7 countries, we face a window opportunity. With the EIC’s support, we pursue the less attractive-to-VC’s SCID indication, as part of our Series A, to become a front row T-cell therapy player, with future chimeric antigen receptor (CAR) therapies in mind. We project to treat >40k patients by 2030 & recover a ROI of 5,28 over our target Series A.

Keywords: regenerative medicine,allogeneic therapies,car t therapies,nk cells,car t cells,immunodeficiency,immuno oncology,lymphoid progenitors,cellular therapies
New pathway and small-molecule compounds for Parkinson’s disease therapy (PARTHECOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-11-30
Duration (months): 27.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

Parkinson’s disease (PD) is a neurodegenerative disease with growing incidence. More than 10 million people worldwide are affected by this condition. In addition to decline in the patients’ quality of life, the economic burden of PD is estimated to exceed 13,9 billion EUR in EU annually. Considering this, novel and more efficient therapeutic options are needed, as current PD treatments alleviate symptoms without stopping neurodegeneration and progression of the disease. Although the etiology of PD is unclear, degeneration of dopamine (DA) neurons has been shown to result from certain genetic mutations, toxins and pathological protein aggregation among others. Importantly, recent evidence points to decrease in mRNA methylation at adenosine N6 (m6A) in PD. Data also indicate that m6A reduction may induce DA neuron apoptosis. Prof. Mart Saarma and collaborators have discovered that m6A methylation is a crucial regulator of neuronal apoptosis. They developed novel m6A methyltransferase activators and demethylase inhibitors that potently enhance mRNA m6A levels. Importantly, preliminary data show that these compounds protect DA neurons from neurotoxin-induced death in culture at nanomolar concentration. Moreover, one compound tested thus far remarkably improves motor behavior, protects and regenerates DA neurons and their axons in rat PD model more potently than “gold standard” GDNF. Considering this, the current project aims to elucidate the mechanisms how m6A regulates DA neuron survival and axonal regeneration. We will identify for the first time the mRNAs with increased/decreased methylation at adenosine N6 that regulate the life and death of DA neurons, thereby potentially opening new directions in PD research. In addition, we aim to provide completely new lead molecules for PD treatment. In conclusion, the current project aims to broaden our understanding on the mechanisms of Parkinson’s disease and provide new drug candidates for novel PD therapeutic avenues.

Keywords: parkinson s disease,neurodegeneration,neuroregeneration,dopamine neurons,mrna methylation,n6 methyladenosine
Deciphering the molecular mechanisms of skeletal muscle fiber fusion (RegenerFuse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1999855.0
EU funding (EUR): 1999855.0
Participants: 1
Project status: SIGNED

Skeletal muscle fibers are highly organized multinucleated cells that grow and regenerate by fusing with myocytes derived from their resident stem cells. The fusion between myocytes and mature muscle fibers, which underpins the remarkable adaptability of muscles, is molecularly distinct from the fusion events that occur during development. This secondary fusion process, also known as myonuclear accretion, integrates mononucleated myocytes into immature myotubes or mature fibers, supporting muscle growth, repair, and regeneration throughout life. Despite its critical physiological importance, the mechanisms governing secondary fusion and the active role of myofibers in this process remain poorly understood. Leveraging the development and application of high-content screening, advanced biochemistry, genetics, cell biology, transcriptomics, and cutting-edge imaging techniques, including 3D correlative light and electron microscopy (CLEM), we aim to provide groundbreaking insights into the molecular and cellular processes of secondary fusion. To achieve this, we will address three independent but interconnected aims: Aim 1: Screen for regulators of secondary fusion and determine their effects using high-content imaging together with exploratory molecular studies. Aim 2: Elucidate the molecular mechanisms and cellular dynamics underpinning fusion hotspots. Aim 3: Establish the physiological relevance of myonuclear accretion in vivo by visualizing fusion hotspots and evaluating the impact of enhanced myoblast transplantation on muscle regeneration and function. This synergistic approach will transform our understanding of muscle physiology, bridging the molecular mechanisms with their functional outcomes. The findings promise to uncover new principles of cell fusion, organelle dynamics, and tissue adaptability, offering profound implications for muscle biology and novel therapeutic strategies for muscle-wasting diseases.

Keywords: myocyte to myofiber fusion,cell fusion,myonuclear accretion,skeletal muscle,correlative light and electron microscopy clem
Understanding the Maintenance and Heritability of Hematopoietic Stem Cell Memories: High-Throughput Drug Screening Meets Single-Cell Barcoding (EpiHTStem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

During the development of multicellular organisms, cells from the same niche can be stochastically exposed to different signals and stimuli, and this variability has the potential to create epigenetic heterogeneity across cell populations. Importantly, this heterogeneity can confer individual cells different functional properties or different capacities to respond to the same stimuli. During the last decade, multiple laboratories have reported the existence of hematopoietic stem cell (HSC) clones with different functional behaviors that are transmitted to daughter cells. Very interestingly, these behaviors are transmitted to their progeny even after transplantation, suggesting that heritable epigenetic components are required to establish and maintain them. In this regard, some questions arise: Which epigenetic regulators are involved in the maintenance of these memories? Which regions associate with specific HSC fate memories? And, how heritable are different chromatin states in dividing HSCs? Until recently, we were very limited by the current technologies to answer these questions. Now, recent advances in single-cell lineage tracing, single-cell multiomics and ex-vivo HSC expansion cultures can be leveraged to provide a robust mechanistic understanding of clonal heritability of HSC fates and states. Consequently, this proposal aims to combine new lineage tracing techniques, multimodal single-cell sequencing and functional assays to: (1) create an atlas of clonally-heritable epigenetic states associated to specific functional HSC behaviors and (2) to identify epigenetic regulators that are required to maintain and transmit HSC memories associated with specific HSC fates.

Keywords: cellular barcoding cell memory single cell analysis drug screening hematopoietic stem cells functional heterogeneity clonal analysis
Speckle Technology and Digital Biomarkers of Microvascular Function for Monitoring Cardiovascular Diseases (STIMULUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Finland,Netherlands,Denmark,France,Germany,Greece
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4613881.5
EU funding (EUR): 4578881.5
Participants: 7
Project status: SIGNED

Over 60 million people in the EU live with cardiovascular diseases (CVDs), at an annual economic cost of +210B€. Despite being largely preventable, CVDs cause more than 18.5 million deaths every year. To combat this, we develop new instruments for assessing adverse changes in microcirculatory status linked to hypertension, chronic kidney disease (CKD) and heart failure (HF), leading to earlier detection of CVDs. The instruments are developed and validated in clinical trials. We integrate two state-of-the-art technologies leading to a novel innovation, 3D speckle tissue monitoring. In addition, we demonstrate a direct use-case for unobtrusive monitoring in a smart-toilet application. Global remote patient monitoring (RPM) systems market is expected to surpass 5 B$ by 2030 with CAGR of 20%. The demand for the RPM systems is rapidly growing among the old age population. Monitoring innovations targeting this group can reduce hospitalization and costly chronic conditions. Furthermore, the technology is closely linked to wearable remote monitoring. The global wearable technology market is expected to grow to 392 B$ by 2030 with CAGR of 13.9%. The opportunity is significant as the number of wearable users currently exceeds 1 billion globally and the developed technology targets similar markets. We currently estimate that with the new instrument and digital biomarkers we can reduce the healthcare burden by over 30% by preventing CVDs. Additionally, we are aiming to identify citizens at risk of developing hypertension, CKD and/or HF and by timely intervention, we expect to reduce indirect healthcare costs by over 20%. In conclusion, our solution will integrate two existing state-of-the-art methods and provide clearly new monitoring techniques to assess the microcirculatory status, revealing early signs of CVDs. We will provide an innovative solution to emerging digital unobtrusive health markets while helping the over 60 million Europeans suffering from CVDs.

Keywords: unobtrusive monitoring,remote patient monitoring,speckle plethysmography,digital biomarkers
On the Spot: Materializing Knowledge, Gender, and Scientific Identities in Eighteenth-century Naturalists' Travel Journals (ON THE SPOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

This two-years project proposes the first material, social, and gender history of eighteenth-century naturalists’ travel journals. The project is particularly timely now that mobility is at the heart of social, cultural, intellectual, gender history and the history of science, and that travel narratives have been recognised as important sources for historical analysis. However, so far only a few studies have been devoted to the travel journal, that very object in which naturalists used to record their observations while travelling. ON THE SPOT will fill this gap, by focusing on the various and still ill-explored archival materials assembled by two famous married collaborators, Antoine Laurent Lavoisier (1743-1794) and Marie-Anne Paulze-Lavoisier (1758-1836) while travelling in the French provinces in the second half of the eighteenth century. Through an interdisciplinary approach, the project will unfold the variety of social, intellectual, and cultural values and emotions operating in the production and use of the travel journal. The project’s broader aim is to provide a theotherical and methodological framework that will allow to understand naturalists’ travel practices as collective and gendered endeavours. The action will be undertaken under the supervision of Prof. Mónica Bolufer at the University of Valencia (UVEG). It will comprise a transversal training in gender history and the acquisition of transferable skills, as well as a targeted program of dissemination and communication activities. Prof. Bolufer’s ERC-funded research project “Circulating Gender in the Global Enlightenment: Ideas, Networks, Agencies (CIRGEN)”, which focuses on transnational approaches to gender, identities, and cultural mediations in Enlightenment societies and cultures, is highly complementary to my experience as an historian of eighteenth-century science, making UVEG the perfect locus for my project.

Keywords: gender and science material history of science paper technologies history of travel
Correlation-driven metallic topology (CorMeTop)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 3356483.0
EU funding (EUR): 3356483.0
Participants: 1
Project status: SIGNED

Developments in the past decade have shaped the term topological quantum matter. In the solid state, much progress has been made on non- and weakly-interacting systems and correlated insulators, but gapless topological phases governed by strong correlations are a completely open challenge. They are of great interest because a wealth of new quantum phases with new properties and functionalities are expected. The PI and her collaborators have recently discovered one such phase - the Weyl-Kondo semimetal - and brought to light its extreme topological responses as well as the feasibility of genuine topology control by external parameters. This sets the stage for the present project. In CorMeTop new correlation-driven gapless topological phases shall be discovered and design principles for such phases established. New signatures of these phases shall be revealed and their potential for quantum devices assessed. To achieve these objectives, the versatile platform of heavy fermion compounds will be used. Four different design principles - symmetry, emergence, engineered platforms, and parameter tuning - will be followed, and a combination of recently established and entirely new experimental probes will be used. The basis for these studies will be high-quality bulk single crystals and thin films grown by molecular beam epitaxy. Among the questions to be addressed are: To which extent does symmetry dictate the fate of topological states in the limit of strong correlations? What is the connection between quantum criticality or other emergent phenomena, long-range entanglement, and topology? Can entirely new platforms based on heavy fermion systems stabilize robust and even braidable Majorana bound states? Which theoretical parameters control topology and how can one vary them experimentally? Which functionalities bear potential for quantum applications? We expect the project to establish an emerging field, and provide guidance to a larger community to boost progress.

Keywords: heavy fermion compounds,electronic topology,weyl semimetal,quantum criticality,emergence,topological superconductivity,low temperature physics,single crystal growth,molecular beam epitaxy,electrical and thermal transport,microwave experiments,entanglement