Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reversing metabolic reprogramming in obesity-associated hepatocellular carcinoma by inhibiting receptor protein tyrosine phosphatases (REPRO-PTP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

REPRO-PTP is addressing the critical need for effective treatments in obesity-associated hepatocellular carcinoma (HCC). HCC, which accounts for 90% of primary liver cancers, is refractory to conventional chemotherapy with very low survival rate. As obesity is a major risk factor for HCC, it is imperative to develop new therapeutic approaches. My laboratory has identified receptor protein tyrosine phosphatases (PTPs) as key regulators of glycolysis and lipogenesis, with PTPRK emerging as a particularly promising target. Mechanistically, PTPRK is selectively increased in tumorigenic hepatocytes, inactivating fructose-1,6-bisphosphatase 1 (FBP1) and promoting glycolysis. PTPRK-mediated glycolysis increases peroxisome proliferator-activated receptor (PPAR)γ-dependent lipogenic signalling and HCC progression in obesity. REPRO-PTP aims to optimize and validate new PTPRK inhibitors that exhibit high selectivity, potency, and in vivo activity. By targeting both hepatic glycolysis and lipogenesis, these inhibitors have the unique potential to improve treatment outcomes for HCC in obese patients by reducing cancer progression and relapse risk. We will provide a robust pipeline for the broader development of PTPRK and additional PTP inhibitors for translational applicability, devise an intellectual property strategy, and perform a commercial feasibility analysis. The project represents a collaborative effort involving experts in oncology, biochemistry, and pharmacology, and is expected to yield novel insights into PTPs as drug targets in cancer and metabolic diseases. REPRO-PTP aims to pave the way for the development of innovative therapies that can improve the quality of life and survival rates for patients suffering from HCC and potentially other obesity-related hepatic complications.
Intelligent Design and Experimental Application of Spectral Splitting and Selective Surfaces for Sunlight (IDEA4Sun)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

This project aims to develop advanced materials solutions for next generation solar energy harvesting systems: Concentrated Solar Thermal (CST) technologies, generating heat, can be combined with Photovoltaic (PV), generating low-cost electricity, in compact hybrid PV-CST systems where PV cells replace mirrors on the concentrators. This type of system will maintain current solar electricity production costs while adding simultaneous heat generation for various end users (residential, commercial, industrial), including the option of thermal storage to address solar intermittency and enable on-demand electricity and heat production. For this application, innovative spectrally selective surfaces are necessary, especially “PV mirrors” splitting the solar spectrum, transparent towards the underlying PV cells and reflective towards the thermal absorbers placed at the focus of the concentrators. Highly absorbing, low emissive solar selective coatings adapted to the truncated solar spectrum are also needed for the thermal absorbers. In this project, these selective surface properties will be achieved by developing efficient multilayered thin film architectures. The latter will first be designed by numerical simulations using advanced optimization methods, using in-house SolPOC open source code. Efforts will be put on reducing environmental impacts, by selecting sustainable materials and minimizing development time and cost through extensive optical simulation. The best solutions will be synthesized by vacuum sputtering deposition to validate the coatings feasibility. Thermo-optical characterizations will validate their performance. Comparisons with simulated optical behavior will validate the design methods, providing a reliable and free tool for developing optical surfaces and solar, accessible to all. Doing thus, the researcher will acquire new experimental skills and increase his employability, while applying his own extensive expertise to fulfill our goals.

Keywords: solar,pv,concentrated solar thermal,optical coatings,plasma deposition
A new concept for mid- to long-term storage of electrical energy in ammonia (AELECTRA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Denmark,Norway,Belgium,Netherlands,France,Greenland,Croatia
Call: EIC Pathfinder Challenge: Mid to long term and systems integrated energy storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4003582.5
EU funding (EUR): 4003582.5
Participants: 8
Project status: SIGNED

AELECTRA will develop a groundbreaking system for energy-efficient long-term electrical energy storage in ammonia. The high risk/high gain concept has the potential to outperform conventional thermochemical Haber-Bosch Reactor (HBR) in CAPEX, at similar OPEX. It is suitable for decentralised on-site use, filling a gap in the market for production scales < 1000 kg/h NH3 (1 kW - 10 MW). The heart of the AELECTRA proposal is to deliver a turnkey system that will demonstrate NH3 synthesis and separation at lab scale. The state of the art will be advanced by identification of optimal reactor conditions, developing reactor & system components and AC/DC power supply. The AELECTRA system is suitable for decentralized use and can store the energy there where it is produced, and thus it can address both spatial and temporal variations in renewable energy production. It can disrupt the chemical industry by delivering the same product as Haber-Bosch Process, however at lower capital costs in large part by eliminating the need for expensive heat exchangers and compressors. The AELECTRA system will be relevant for multiple industry sectors, including power production, food, pharma, shipping as well as fertilizer production. To reach these ambitious goals AELECTRA will draw on the complimentary expertise of three research teams (AU, VITO and SINTEF); catalyst manufacturer C2CAT; power to X and X to power industry player ELTRONIC Fueltech; ANORI, a company investing in renewable energy projects in the northern part of the globe (Greenland); and ADISSEO, a French company that produces methionine using ammonia as feedstock.

Keywords: liquid ammonia,electrochemical synthesis,energy efficiency
Towards a new era of representative democracy - Activating European citizens’ trust in times of crises and polarization (ActEU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Belgium,Czechia,Finland,France,Greece,Italy,Poland,Spain
Call: Representative democracy in flux (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 3044120.0
EU funding (EUR): 2999870.0
Participants: 13
Project status: SIGNED

How can we conceptualize and empirically measure political trust and legitimacy beyond the usual survey question “How much trust do you have in the parliament?”? Does the multi-level nature of European representative democracies require an identical level of citizen support at the regional, national and EU levels? How does social polarization on key policy issues of our times –immigration, climate change, and gender inequality– challenge the political trust in, and legitimacy of, democratic political systems? And what can policymakers and civil society do to master these challenges? ActEU aims at finding answers to these questions pursuing two overarching goals: In phase 1, we map and investigate persistent problems of declining trust, legitimacy and representation in Europe with a particular attention to the polarization of societies and the EU’s multi-level structures. Providing an innovative conceptual framework on political attitudes, behavior and representation across Europe, we establish an original empirical infrastructure based on an innovative combination of methods and newly collected quantitative and qualitative empirical data (focus groups, experimental surveys, web scraping). In phase 2, these results will flow directly into the creation of a toolbox of remedial actions to enhance political trust in and legitimacy of European representative democracies. In cooperation with a newly created Civil Society Network, Youth Democracy Labs across 13 European cities and in exchange with political cartoonists “Cartooning for democracy”, we will develop context-sensitive solutions for all polity levels and some of the most polarizing policy areas, and craft tailor-made toolkits for both policymakers and civil society and the educational sector. Finally, we deploy a differentiated dissemination strategy to maximize ActEU’s scientific, policy and societal impact in activating European citizens’ trust and working towards a new era of representative democracy.

Keywords: political trust,legitimacy,participation,representation,polarization,immigration,gender,climate change,experimental survey,web scraping,focus groups,civil society,educational sector
FEAST (FEAST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Germany,Portugal,Greece,Belgium,Denmark,Norway,North Macedonia,Ireland,Austria,France,Netherlands,Italy,Poland,Switzerland,United Kingdom
Call: Transition to healthy and sustainable dietary behaviour (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 11724640.0
EU funding (EUR): 11724640.0
Participants: 36
Project status: SIGNED

FEAST (Food systems that support transitions to hEalthy And Sustainable dieTs) aims to support the EU's just transition to healthy diets produced by sustainable food systems. Using a Multi-Actor Approach, FEAST will leverage current best practice and co-design novel solutions with EU food system stakeholders, including diverse vulnerable groups, to identify how they can be supported and empowered to facilitate and benefit from the transition to healthy and sustainable dietary behaviour at all levels and in all sectors of the food system. FEAST's objectives are: 1.To better understand, describe and measure barriers and facilitators that influence the dietary behaviour of different groups (particularly vulnerable groups), accounting for geographical, socio-economic, behavioural, gender and cultural differences 2.To collaborate with key stakeholders in Europe’s food systems to identify and/or design and test innovative and effective tools, programmes and strategies, including social innovations, that will enable consumers to make informed food choices that promote the self-management of healthy and sustainable dietary behaviours and lifestyles 3.To empower individuals to adopt healthier and more sustainable dietary behaviours, choices and lifestyles by means of evidence-based strategies and tools addressing all food system actors at the level of Member States, EU and wider international community 4.To increase the adoption of food and health policy interventions that aim to drive the transition to healthier and more sustainable diets by all stakeholders within the food system by designing and testing scientifically-informed ommunication strategies, and associated monitoring approaches, that could be used by policymakers All stakeholders will be invited to our FEAST project and we will not accept that anyone is left behind or is left hungry and wanting because we do not believe in zero-sum games - we adhere to the principle that all must ‘Win’.

Keywords: food systems just transition
Electro-thermal energy converter using novel combined thermoacoustic and electrocaloric system (THERMINATOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: France,United Kingdom,Germany,Slovenia,Spain,Switzerland,Romania
Call: Emerging energy technologies for a climate neutral Europe (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2326551.25
EU funding (EUR): 2326551.25
Participants: 9
Project status: SIGNED

Energy and transport are the highest emitters of greenhouse gases in the EU at 25% and 21% respectively of total emissions. Efficient management, conversion and distribution of thermal energy as well as converting excess or wasted heat into electricity presents a major opportunity to reduce greenhouse gas emissions and achieve net zero by 2050 in the energy and transport sectors and beyond e.g. heating and cooling distribution in buildings and districts, improved efficiency in renewables and more efficient, longer range electric vehicles. THERMINATOR will develop a new energy conversion technology in the form of an efficient low profile energy conversion “skin” that can be integrated into the fabric of a building or the wall of a pipe to reduce energy loss through active insulation or to provide temperature conversion in heat networks. It could be applied as a backing to improve efficiency of solar cells or integrated into the structure of a vehicle to support passenger comfort or improved efficiency of structural batteries. This novel technology integrates thermoacoustic and electrocaloric stages and operates at high frequency to achieve high power density (100W/cm2). Model-based smart controls and energy management will provide high efficiency and digital control for optimum performance and reliability and integration into digital networks. A focus on sustainability, circularity and socio-economic factors will ensure products with high environmental and social benefit. Developments will be validated to TRL4 by testing in use cases in thermal networks, solar generation and electric vehicle applications. THERMINATOR disruptive technology will support European companies in developing new high performance sustainable products through consortium members in thermal networks and solar power sectors alongside world-leading expertise in electrocaloric, thermoacoustic and ultrasonic technologies and skills in reliability, environmental assessment and exploitation planning.

Keywords: energy,power,transport,climate neutral,electric vehicles,electronics,electrocaloric,thermoacoustic,pyroelectric,heat engine,heat pump,efficiency
Nanoscale analysis of symmetry and molecular membrane topography (nano-Asymmetry)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

The compositional and structural asymmetry of cell membranes remains one of the greatest knowledge gaps in cell biology. Cells invest significant amount of energy to establish and maintain inter-leaflet asymmetry; however, the physiological roles of bilayer lipids during dynamic cellular processes in eukaryote membranes remain poorly understood, mostly due to the limits of previously available methodologies and the complexity of lipid membranes. Current knowledge originates from indirect and perturbing techniques (i.e. enzymatic digestion and mass spectrometry) which significantly limits the applicability to certain cell types with no internal membranes. Moreover, these bulk methods do not provide spatial information on lipid asymmetry which prevents detailed observation of subcellular changes during dynamics processes such as host-pathogen interactions. In this project, I will develop a method to directly visualize and quantify membrane asymmetry, which will be applicable to study any cell type as well as intracellular membranes. Recent advances in super-resolution microscopy, including my latest publications, paved the way for direct observation and quantification of lipid asymmetry. I will combine state-of-the-art isotropic expansion methods with super-resolution microscopy to visualize membrane lipids in individual leaflets of bilayers. To obtain further insights on the physiological role of membrane asymmetry, I will investigate changes in lipid asymmetry induced by infection with viral particles. The novel methods I will develop will significantly contribute to a better understanding of lipid asymmetry in biological membranes and its impact in cellular physiology and diseases mechanisms.

Keywords: super resolution microscopy,expansion microscopy,dstorm,sted,lipid asymmetry of biological membranes,biomimetic cell models,
DecIphering nucLEar Mechanics in diabetes: a Multi-scAle perspective (DILEMMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

DILEMMA will orient fundamental research to fill a gap in diabetes mellitus (DM) biology, by addressing a relevant biomedical problem in a cross-disciplinary manner, with great societal and economic impact. I will use a unique combination of advanced nanoscopy with protein biochemistry and cell biology. Clinical studies identified stiffening in vascular, muscle and connecting tissues as particular mechanical fingerprints for DM. In diabetic patients advanced glycation end products are clinical biomarkers of DM that correlate with increased heart failure risk, but the mechanism of action bridging the mechanical alterations at molecular and tissue levels remains elusive. Current techniques used to inspect biochemical regulation of proteins fall short at describing the interplay between their dynamics under force and biological function. An in-depth multiscale characterization of the mechanical landscape in DM is a promising approach to identify new mechanical biomarkers able to advance therapeutic and diagnostic strategies. DILEMMA will study the fundamental link between tissue stiffening and protein glycation modifications in DM at multiple scales relevant for mechanobiology. I will explore the hypothesis that in diabetic patients lamin proteins are modified by glycation, which disrupts nuclear mechanical homeostasis. DILEMMA will have a strong impact in DM biology by providing new tools to understand how protein glycation and nuclear mechanics set the mechanical properties of cells and tissues in pathophysiological conditions. I will receive training and education to acquire or strengthen my technical, scientific, and soft skills. This action will impact my career, representing a jump that will advance my future goal of becoming an independent young leader and establishing a unique research line at national level. DILEMMA could improve future clinical practice and reduce economic burden on the health system.

Keywords: nanomechanics,cell mechanics,single molecule,atomic force microscopy,magnetic tweezers,nucleus,diabetes
Medieval Serbian Charters Action - Towards a Digital Edition of the Royal Charters of Medieval Serbia (MeSeCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

The aim of the proposal is the improvement of substantial, technical and software aspects of the digital database of Serbian medieval charters named Diplomatarium Serbicum Digitale (DSD) in cooperation with the Zentrum für Informationsmodellierung (ZIM) of the Graz University. The main objectives are to complete the database material, containing of edited document texts, metadata and images, and to conclude its transformation into a scholarly digital edition according to the current standards of Digital humanities. The DSD project has been established by me and my colleagues from Belgrade in order to fill the void in the research left by the lack of a comprehensive edition of Serbian medieval charters. As its growing digitized material was accessible within the online-database only until mid-2020, when the respective domain expired after the funding by the EU in frames of an international project had been concluded, the future of the undertaking is now depending on the possibilities of its digital transformation and continuing of the research work on editing texts and diplomatic analysis. The best opportunity for achieving those goals would be my longer stay in Graz, continuing the fruitful partnership with the director of the ZIM, professor Georg Vogeler, belonging to the European leading experts in Digital diplomatics, and his colleagues. The cooperation with the ZIM is a necessary step in order to make a digital edition possible and solid performable, especially concerning application of XML standards, publication strategies and long-term archiving. During the stay in Graz I will also firm up my competences in the field of Digital humanities, which are still missing in the Serbian universitary landscape. In that way I would like to give a contribution to the medieval research of my region, but also to present myself as a candidate for a programme in Digital diplomatics, being introduced at the Philosophical faculty in Belgrade.

Keywords: medieval charters scholarly digital editions southeast european documentary heritage of the middle ages between western and eastern influences multilingual pragmatic literacy digital humanities