Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI in Parkinson's Disease (AIPD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Luxembourg,Belgium,Ireland,Netherlands,Italy,Denmark,France,Spain
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 4057558.97
EU funding (EUR): 3722580.0
Participants: 15
Project status: SIGNED

In response to the growing need for specialized data scientists in healthcare, our initiative aims to establish an international, interdisciplinary graduate school that educate the next generation of medical data scientists, with a strong translational focus bridging academia and industry. This is strengthened by the active involvement of leading global pharmaceutical and med-tech companies as well as SMEs in the AI field, thus ensuring that our research and training remain at the forefront of industry and healthcare. We propose a comprehensive training program offering PhD students not only a robust foundation in data science, including AI/ML and digital health, but also a deep understanding of ethical, legal and regulatory frameworks, including GDPR, the European Health Data Space and the AI Act. Our curriculum is unique in its integration of entrepreneurial thinking and a focus on Parkinson’s disease (PD) as an application field. At the same time, the methodologies and insights gained will have broader applications in various disorders, thus applicable to other areas of healthcare. We will move with our research program clearly beyond the state of the art by: - Developing new AI/ML models spanning the entire journey of a PD patient to support medical decision-making on a more individual basis, - Pioneering the use of recent causal AI/ML techniques in PD research, - Investigating the optimization of future clinical trials, - Providing novel insights into digital and neuroimaging markers, - Developing innovative algorithmic solutions to enhance the generalizability of AI/ML models, - Providing understanding of the ethical, legal and regulatory basis of the use of AI in medical practice. All participants are highly committed to the research, teaching, supervision and management activities in this program, and this commitment is supported by existing working relationships through other projects, such as ERA PerMed DIGIPD, IHI PREDICTOM and IHI IDERHA.

Keywords: precision medicine,parkinson s disease,digital health,trustworthy ai
From Supramolecular to Covalent Boron Clusters Membrane Carriers (CONNECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Conceptually new synthetic membrane transporters constitute a key challenge for supramolecular chemistry and materials sciences. To date, the transport of hydrophilic bioactive substances across membranes has exploited the amphiphilic character of carriers and cargos such as in lipids or other cationic amphiphiles. However, amphiphilic molecules face limitations due to intrinsic features such as toxicity associated to their detergent-like behaviour and their tendency to aggregate. This year, it has been described that superchaotropic boron clusters can transport a range of hydrophilic chemical substances across lipid membranes and inside cells. This new concept supports that the chaotropic effect can guide the design of an entirely new class of membrane carriers. However, until now, boron clusters have only been used as non-covalent carriers of the cargo of interest. The main objective of this action is to investigate, for the first time, the covalent introduction of superchaotropic substituents into prototype peptide sequences and evaluate their potential to be self-transported across membranes. A selection of simple anionic, cationic and hydrophobic peptides will be equipped with boron clusters modified amino acids and screened in model membranes and in cell assays. Unknown concepts and revolutionary molecules could emerge from this initial study. For example, the introduction of anionic boron clusters into cationic short peptides could give rise to a new class of (strongly hydrophilic) zwitterionic self-transported biomolecular scaffolds. We also suspect that switching hydrophobic for anionic chaotropic residues will decrease aggregation propensity but increase membrane transport efficiency of amphiphilic bioactive peptides. This new application of chaotropic cluster will impact the field of membrane transport by using more controllable, non-aggregating and less toxic synthetic vehicles.

Keywords: supramolecular chemistry,superchaotropic carriers,globular boron clusters,synthetic membrane carriers,vesicles transport experiments
Advancing Knowledge of North Atlantic Land ICE - LINKing Observations and Models (ICELINK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Denmark,Iceland,Greenland,Belgium,Austria,Germany,Spain
Call: Inland ice, including snow cover, glaciers, ice sheets and permafrost, and their interaction with climate change (HORIZON-CL5-2024-D1-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 7412137.75
EU funding (EUR): 7412137.75
Participants: 11
Project status: SIGNED

ICELINK will bridge the knowledge gap between climate models, ice-flow models, satellite observations and in-situ observations to accelerate the understanding of how glaciers and ice sheets in the North Atlantic respond to climate change, and their impacts on climate and ecosystems. Observations in the past decades have alerted for the rapid changes in land ice in this region. Record temperatures, melting ice and increased fresh water flux may destabilise the atmosphere and ocean circulation, with severe consequences for regional weather system, sea level rise, and affecting Europe and beyond. An improved understanding of trends and variability of ice evolution is important, and ICELINK will address this challenge by integrating Earth Observation data, in-situ observations and ice flow and climate models into an improved understanding of the processes that control the evolution of glaciers. Through improved understanding of snow, surface mass balance and the ice dynamical response to meltwater runoff, ICELINK will provide new knowledge of the response of Icelandic glaciers and the Greenland ice sheet to global warming and the impacts on climate and ecosystems. ICELINK will engage closely with local communities to co-develop and disseminate new knowledge, needed to support adaptation strategies, mitigate risks and enhance their resilience. A novel approach in ICELINK is to investigate the effect of increasing surface melting on ice evolution of the Greenland Ice Sheet by using Icelandic glaciers as a data-observation laboratory for understanding the response in a warmer world with more melt. The improved models and new insights will feed into the World Climate Research Programme’s Cryosphere Project, IPCC, IPBES, assist development of Copernicus, and support the Destination Earth Initiative. ICELINK will produce results that are in high demand in order to plan and adapt for the future.

Keywords: glaciers,ice sheets,snow,earth system models,regional climate modelling,ice flow modeling,earth observation,ice cores,monitoring,climate change,impacts,greenland,iceland,north atlantic
next-Generation Handling of Optical Stray-light in Telescopes (nGHOST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1963750.0
EU funding (EUR): 1963750.0
Participants: 1
Project status: SIGNED

In the ever-evolving realm of space instrumentation, the quest for excellence is endless. Scientists tirelessly pursue optical instruments that can capture the universe in unparalleled clarity. Over the years, instruments have improved through the introduction of innovative design concepts and manufacturing techniques, as well as with the use of better detectors. However, for the most demanding applications, stray light (SL) increasingly emerges as the primary limiting factor. SL must be minimized by design through optimal opto-mechanical layout and material selection. In the most challenging situations, this is however not sufficient and a post-processing correction is necessary to reach the scientific requirements. For that, SL characterization is conducted on-ground, to ensure that the instrument does not present any unexpected defect, and to provide kernels for the SL correction algorithms. However, the capabilities of SL characterization were stretched to their utmost extremes. Identifying defects is extremely complex and often impossible, and SL correction algorithms require SL measurement campaigns which are time consuming and subject to inaccuracies. To enable the development of the next generations of space optical instruments, a new paradigm is necessary. This is my long-term scientific objective and the heart of this project. In that frame, my objective will be to mature a new technology: the SL characterization by use of ultrafast time-of-flight imaging.

Keywords: stray light,optical testing,optical calibration,ray tracing,baffle,space instrument,ghost reflections,scattering,radiometric accuracy,high contrast imagers
LAW, STATE, REPUBLIC: An Interpretation and Defense of a Kantian Critical Reflective Constructivism (LSR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1992629.0
EU funding (EUR): 1992629.0
Participants: 1
Project status: SIGNED

LSR will defend a novel interpretation of Kant’s Doctrine of Right which will allow a reevaluation of LSR will defend a novel interpretation of Kant’s Doctrine of Right which will allow a reevaluation of central issues of his political and juridical philosophy from both the historical and systematic points of view. It will also elaborate new Kantian perspectives for dealing with contemporary normative challenges in the fields of political philosophy, philosophy of law, and political and legal theory. It will investigate two groundbreaking hypotheses. First, that Kant's philosophy of law and right is permeated with the use of reflecting teleological judgment which influence the meaning and normative content of the rational principles of right. Teleology sets up a complex relationship between the a priori and the empirical levels, between practical reason and the pragmatical anthropology as well as between the procedural and dynamical aspects embodied in a specific conception of history. Second, that on a deep methodological level, Kant's philosophy can be understood as grounded in a reflective constructivism that can be developed and updated as a powerful philosophical method for dealing with complex problems about the relation of different forms of normativity, the issue of interdisciplinarity, and the relationship between theory and practice. From the development of those hypotheses, it will be investigated how Kant’s philosophy of right may present innovative solutions for issues such as the following: the relation between external coercion and normativity in the context of the theories of juridical positivism; the requirements concerning the ideal of the rule of law; the relation among the principles of right and history and anthropology; and issues regarding the legitimacy of property, economic and intergenerational justice, cosmopolitanism, human rights and democracy. This project therefore has three strands: a historical, a systematic and a methodological one.

Keywords: right,law,state,republic,constructivism,cosmopolitanism,human rights,democracy,justice
Constructing AMLO: Political Persona, Visual Media and Populism in Mexico (POPAMLO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Mexico
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

The global resurgence of populism continues to have devastating legislative effects, particularly for human rights and media independence. While contemporary scholarly investigations into this political phenomenon tend to focus on right-wing populist figures, it is essential to broaden understanding beyond this current anxiety to combat the rise of anti-democratic movements. A more nuanced understanding of populism derived from this study will decentralise the Eurocentric conflation of populism and the political right that exists at present. The proposed project will respond to the rich scholarship emerging from Latin American scholars on left-wing populism to enrich global debates and critical reflection on the question of how to define populism and challenge its pervasive narratives. The project will examine the visual representation of left-wing Mexican populist president Andrés Manuel López Obrador (2018-2024) from his first presidential campaign in 2006 to the end of his first year in office in December 2019. Scrutinising this case study in dialogue with other Latin and North American populists, the proposed research will facilitate closer engagement with present-day populism, public persona and the mediatising of politics. With ten years of experience in researching the representation of Mexico’s political system, predominantly through film and visual media, and with a focus on its figureheads, I am uniquely qualified to pursue this line of investigation. To deliver this project, I will be drawing on five documentary texts, a selection of televised morning press conferences (mañaneras), and referencing social media in order to analyse the creation of a political persona in the context of the Mexican socio-historic landscape. My deep interest and expertise in contemporary Mexican politics, media and art, my commitment to decolonizing research and scholarship, and my extensive portfolio of work on the intersection of these subjects will form an exceptio

Keywords: representation,documentary,politics,populism,elections,political persona,mexico
Assessment of the potential of a smart energy router based on the Super-HEART technology for vertical farming (Heart4Farms)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Germany
Call: EIC Booster grant for EIC Pathfinder and EIC Transition (HORIZON-EIC-2023-BOOSTER-IBA-01, 2023)
Start date: 2024-06-01
End date: 2024-11-30
Duration (months): 6.0
Total project cost (EUR): 46594.0
EU funding (EUR): 46594.0
Participants: 1
Project status: CLOSED

Vertical farming is a promising technology to address the challenges related to the impact of climate change on agricultural production, the increased demand associated with global population growth, and urbanisation. However, vertical farms are energy-intensive plants with specific requirements. The technology and system-level design and control optimisation developed in the EIC Transition project 'Super-HEART' involves research and development on multiport power converters. Their unique features such as the high density, low loss, and fault tolerance, can address the specific needs of the application. The aim of this project is therefore to provide a systemic and systematic benchmark assessment of the costs and benefits of the technology developed in Super-HEART for the supply of vertical farms.

Keywords: multiport converter,smart energy router,energy hub,vertical farming,
SEvere MAlaria treatment with Rectal artesunate and Artemisinin-based Combination Therapy [in remote settings] (SEMA ReACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Belgium,Tanzania, United Republic of,Zambia,Congo, The Democratic Republic of the,Switzerland
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 3984316.25
EU funding (EUR): 3984316.25
Participants: 5
Project status: SIGNED

Annually, almost 500,000 children under 5 years die from malaria in Africa. Timely access to effective antimalarial therapies is life saving as treatment with pre-referral rectal artesunate (RAS), followed by injectable artesunate and 3 days treatment with ACTs leads to an observed 96% reduction in mortality. Though recommended by the WHO for years, RAS deployment is very limited. The full treatment paradigm is not always feasible when access to primary healthcare facilities is limited due to lack of transport, non-availability of services, and cost. Rollout has recently been paused as outcomes data is incomplete in these contexts making the development of best practice recommendations challenging. Hence the relevance of the proposed study. The proposed project is an observational, non-inferiority study in Zambia and DRC. Community Health Care Workers will identify/diagnose, treat and follow up patients with (severe) malaria as part of integrated community case management. We will compare the efficacy of a treatment regimen consisting of pre-referral RAS, then post-referral injectable artesunate, followed by three days of ACT versus a regimen consisting of RAS alone followed by three days of ACT in remote areas. We will compare recurrence rate between the two regimens at Day 28, the number of lives saved, the risk of generating drug resistance. We will assess and mitigate operational and institutional facilitators and barriers in all stakeholders (patients, caregivers, health care providers, regulators, malaria experts) and recommend sustainable policies for this remote context. This generated evidence will support policy development and implementation. The proposed consortium brings together vital experience in the rollout and deployment of rectal artesunate, study design and execution, social science, data collection and management, stakeholder engagement and translation of research results into clinical practice.

Keywords: severe malaria,remote areas,
Rebalancing disruptivE Business of multinAtional corporation and gLobal value chAins within democratic and iNClusive citizenship processes (REBALANCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Netherlands,Sweden,Ukraine,United Kingdom
Call: Economic models and modern democracies (HORIZON-CL2-2021-DEMOCRACY-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2326186.25
EU funding (EUR): 2326186.25
Participants: 8
Project status: SIGNED

While globalization, financialization and monopolies increasingly weaken democracies, large companies are having an ever-greater influence on how democracy is enacted in Europe, leading to a ‘market-conforming capitalism’. Firms are eluding regulation, lobbying for their own rather than citizens’ interest, abusing human rights and push the abused to withdraw from democratic processes, fuelling populism. Some economic actors are experimenting with alternative models and demonstrating more interest in sustainability and tentative routes toward an alternative “democracy-conforming capitalism”. In this debate, the application of political-science lenses has black-boxed large companies, while the viewpoint of management scholars has usually considered firms’ economic gains rather than impact on society and democracy. This has left a gap in our understanding of the mutual influence among large companies and democracies. The REBALANCE project will fill this gap by investigating how large companies (1) have contributed to past and present threats to democracy; (2) can promote future democracy-enhancing business models and alternative organizational forms. The project will identify: - the most effective regulatory control of economic actors, which avoids anti-democratic distortions and reveals human rights violators, and what makes large firms accept or resist such control - ways to tackle (self-)exclusion from the democratic participation of victims of business-related human rights infringements and other marginalized categories, relying on empowerment-centered partnerships between firms and other entities (e.g.. NGOs) - whether and how companies respond to populisms, and how alternative organizational forms such as social enterprises might embed and foster democracy. The expected project outcomes are in line with the call for: ‘Theoretically and empirically robust recommendations aiming to instill greater democratic accountability and inclusion in economic processes'.

Keywords: multinational enterprises,human rights,democratic processes,social enterprises,populism,csr,profit non profit partnerships