Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of transcription factor Hlf in hematopoietic stem cells (HLF IN HSC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Adult stem cells necessitate a transcriptional state that sustains multipotency and self-renewal for lifetime. Hematopoietic Stem Cells (HSC) are the source of all blood cells and lead both biological study and clinical utilization of stem cells – by saving thousands every year with bone-marrow transplant. However, understanding how HSC sustain stem-cell state is still limited. During my PostDoc I have generated and analyzed extensive microarrays expression datasets, identifying numerous candidate-regulators for HSCs. One of the top-hits, Hlf, also showed robust in vitro induction of HSC-like immunephenotype and functional activity. Now, focusing on Hlf aims to elucidate the molecular networks of transcriptome regulation in primitive primary hematopoietic cells. With the generation of a new reporter/conditional knockout mouse the endogenous role of Hlf will be further revealed. Taken together, this proposal continues my previous research, and going to shed new light on HSC regulation. Implications of such findings are relevant to lymphoma, and to development of novel ways to increase utilization of HSCs.

Keywords: hematopoietic stem cells (hsc),self-renewal,multipotency,hepatic leukemia factor (hlf),transcriptional regulator of stem cell state.
Dopaminergic regulation of immunity (DOPAMINE  IMMUNITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Common knowledge and extensive scientific evidence suggest that the brain affects the immune system. Our goal is to understand the underlying mechanisms and to harness the networks involved in this communication toward the design of new therapuetic strategies to centrally regulate immune responses. The proposed research plan integrates state-of-the-art technologies in both neuroscience and immunology disciplines, merging them into a multidiciplinary research project. Here we focus on the role of dopamine (DA) and dopaminergic networks in immune regulation. DA is associated with emotions, movement, and the brain’s pleasure and reward system. Dopamine-regulating drugs are used to treat Parkinson’s disease, hypertension, mood disorders and attention deficits. However dopamine can also modulate the immune system. The mechanisms underlying the dopamine-mediated regulation of immunity remain elusive. The proposed research suggests studying how the specific dopaminergic neuronal networks in the brain participate in immune regulation. To this aim we utilize cutting-edge research tools to systematically investigate and establish causality between dopaminergic circuits in the brain and the immune system; manipulation of neuronal activity will be obtained via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) and optogenetics. High throughput analysis using Luminex and CyTOF will provide a “bird's-eye view” of the influence of DA neuronal activity on the immune system and will also serve to point to relevant directions for future research. My scientific background provides the expertise required to execute the presented research plan. As a graduate student I focused on immune system-related regulation of the brain. In my postdoctoral fellowship I focused on neuronal regulation of arousal mechanisms, acquiring the experimental skills in optogenetics and neuronal manipulation. As a new independent researcher at the Technion I propose to combine these fields

Keywords: immune neurons dopamine neuroimmunology psychoneuroimmunology
Exploring the changing genomic landscape during neural fate acquisition in Drosophila (NEUROMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Western societies are faced with a variety of human conditions of neurological nature spanning from cancer to psychological disorders. In biomedical research Drosophila has been used extensively as a genetic model organism to study development and disease related phenotypes. Many key molecules that participate in the development of the nervous system are conserved from fly to human. Here, I propose to combine the powerful Drosophila genetics with the novel deep-sequencing assays to reveal what determines the neural stem cell (neuroblast) fate in the developing embryo. In particular, I propose to map the genome binding events of co-operating key gene regulatory transcription factors specifically in the early neuroectoderm from which nascent neuroblasts will arise. I will also document the chromatin structure and gene expression profiles in these two distinct tissues, neuroectoderm and neuroblasts. This systems biology approach will reveal what determines neural stem cell biogenesis at the global genomic level, which remains to date unexplored. Drosophila is ideal for this approach, as it affords sophisticated transgenesis tools for the targeting of bait molecules to specific tissues and developmental stages. In addition, I aim to integrate our Drosophila data with available expression data form human neural tissue diseases in order to discover potential novel candidates relevant for human disease by cross-species bioinformatics. The successful completion of this proposal will be the cornerstone in my career development path establishing me as a competitive independent researcher in the field of transcriptional regulation of complex multicellular systems.

Keywords: drosophila,embryo,neural development,genomics,neurosciences,chip-seq,proneurals,transcription,chromatin,proteomics,systems biology,neuroblasts,neuroectoderm,stem cell fate
The Antitheatrical Prejudice: Roman Ban on Permanent Theater and the Triumph of Pompey (THEATRICALITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2015-01-01
End date: 2019-01-10
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

This study examines the cultural and political processes leading to the institution and resolution of the (unwritten) ban on the permanent theater, effective in Rome, from 154 BCE until the construction of Pompey’s Theater-Portico Complex (61-55 BCE). Previously approached from the viewpoint provided through textual evidence, the crisis of the permanent theater has been interpreted as a power struggle between masses and the Roman elite. Building on my dissertation research, this work takes a new perspective. By situating the issue in an interdisciplinary Hellenistic context, my project presents the crisis of permanent theater as an inter-elite problem, a struggle between the Roman Senate and powerful political actors like Gnaeus Pompeius Magnus (“the Great”). To demonstrate this point, using historical and archaeological evidence, I analyze spatial development of Roman theater buildings in South Italy and Sicily parallel to the urban development in Rome in the period between the introduction of the Greek theater to Rome in 240 BCE and the construction of Pompey’s Theater-Portico Complex. I focus on the monuments alongside the triumphal path leading to Pompey’s monument. The exploration of theater and urban space is carried out together with narrative analysis of theatrical performances, processions and sacrifice, which occasionally take place in the context of a civic festival or triumphal celebration. An accompanying reconstruction of the theatrical events and triumphal procession in Rome concluding at Pompey’s Theater-Portico complex illuminates how Roman theater building and urban space worked politically before and during the First Triumvirate. The three dimensional images produced by the research team illustrate theatrical moments increasing the popular appeal of published results. This study establishes cultural connections between the Hellenistic East and the Republican Rome contributing to European history and recent debates on globalization.

Keywords: ancient perspective,scenography,globalization,technology,urban design,architecture,theatre,stage design,morality,power,hellenistic period,pergamon,republican rome,media,material culture
Unraveling the Molecular Basis And Regulatory Function Of Genome Architecture By Monitoring Its Dynamic Makeup During Differentiation And In Differentiated Cells (3D GENOME DYNAMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposed study addresses a major issue in the field of genome biology: how cells adopt specific genome configuration during differentiation, how is it maintained, and how properties of nuclear architecture relate to cell function. Although spatial clustering of genes and regulatory elements is correlated with transcription status and epigenetic states, it is not clear which mechanisms drive, which features follow, and what is the regulatory role of nuclear organization. Our studies in numerous cell types have identified the enrichment for transcription factor (TF) binding loci as the salient feature of genomic loci residing in active sub-nuclear environments. Surprisingly, the coordinated chromosomal associations were not correlated with transcription response. Thus, we hypothesize that TF interactions with the genome are key for the establishment of genome three-dimensional organization. To understand how nuclear architecture is modulated during differentiation we propose to study the coupled dynamics of genomic association networks together with multiple genomic layers of genome regulation (transcription, transcription factor binding, and epigenetic states) during adipogenic differentiation in high temporal resolution. Moreover, genome architecture data will be combined with DHS-seq profiles for unbiased examinations and discovery of nuclear organizing factors. To understand how genome organization is maintained we will study differentiated mammary cells. We will validate our findings with molecular perturbations, and combine genomics with single cell analysis by imaging. Lastly, to understand genome organization transitions, we will study the dynamics of genome organization throughout the cell cycle in high molecular and temporal resolutions. Importantly, we will link nuclear organization to cellular function by studying functional and terminal differentiation.

Keywords: gene expression,nuclear organization,genome architecture,differentiation,gene regulation,chromosome conformation capture,genomics,adipogenesis
Investigating the 2D Self-Assembly of Photo-sensitive Molecules on Semiconductor and Insulating Surfaces (PHOTOSURF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The PHOTOSURF project will investigate self-assembled networks of photo-sensitive molecules formed at semiconductor and dielectric surfaces. The interaction between light and photo-sensitive dye molecules adsorbed on semiconductors plays a pivotal role in several renewable energy technologies: dye sensitised solar cells (DSSC) and the photo-catalytic production of solar fuels. In both of these applications the configuration of dyes with respect to each other and the underlying surface is a key factor in determining how efficiently solar energy is converted to either electricity or to green fuel sources. Knowledge of how the nanoscale organisation of molecules influences the operation of solar energy devices, coupled with an increased ability to control that organisation, will help to maximise the efficiency of such devices. Self-assembly is a process by which individual molecules can organise themselves into ordered and complex structures through simple intermolecular interactions. In recent years the formation of ordered molecular networks on surfaces using 2D self-assembly has been an area of intense research. PHOTOSURF will use concepts from the field of 2D molecular self-assembly to control the structural arrangement of photo-sensitive dye and catalyst molecules on semiconductor and dielectric surfaces. These molecular structures will then be investigated using a range of techniques including scanning tunnelling microscopy (STM) and scanning microwave microscopy (SMM). Such experiments will allow the project to study charge transfer, photo-catalysis and light harvesting effects at the level of individual dye molecules. From these studies we will gain a deeper fundamental understanding of how molecular orientation, bonding and arrangement influences these physical and optical processes. This knowledge will be vital to the future development of cost effective solar energy technologies.

Keywords: nanoscience,nanotechnology,self-assembly,solar energy,photo-catalysis,light harvesting,scanning probe microscopy
Variability and Trends in Atlantic Climate (ATLANTIC CLIMATE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-23
End date: 2017-09-22
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The NAO is affected by processes internal to the troposphere, and by “external” effects from the stratosphere above. In today’s climate, it is not understood what fraction of NAO variability is attributable to the stratosphere. This project is focused on understanding future climate—how the NAO will change, how jets and storm tracks will shift. It is an important challenge, because without a fundamental understanding of the physical processes involved, and without models that realistically simulate these changes over time, we are left with low confidence in climate projections—especially how climate will change over the large European sector. Thus, this topic is highly relevant to society. Following a 25-year highly successful career at a private research institute in the United States, I moved in 2012 to the UK to join the faculty of the University of Exeter. This CIG project is designed to help me to integrate into both the EU and the University system. To me, integration into the EU means developing a successful career as an educator and researcher, mentoring graduate students and post-docs, whilst maintaining an adequate stream of external funding to support these activities. This project primarily supports a graduate student, and is a key component of my integration into the EU. This integration is particularly challenging because it is not possible to take US-based funding to any institution out- side the US. This is a current problem with an urgent need for a solution. This problem is highly relevant to society, and the results have practical benefits. This proposal pushes the frontiers of research knowledge in two closely intertwined areas: 1) vertical coupling of the stratosphere to the troposphere (primarily the NAO), and 2) how state-of-the-art climate models do not do an adequate job of simulating variability of the jets and storm tracks (closely related to the NAO)—which calls into question the climate projections made using these models.

Keywords: north atlantic oscillation,stratosphere,jet streams,storm tracks,climate change
The molecular physiology and the evolution of a new pathway promoting developmental stability (FLY-PHY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Developmental stability is the ability of an organism to buffer given traits against environmental and intrinsic perturbations. This may involve physiological, temporal or behavioral adjustments to the developmental program. The processes leading to developmental stability have been particularly well studied in arthropods. For instance, if uncoordinated growth is induced in the larval imaginal discs (the precursors of adult appendages) of Drosophila flies, a transient delay in the onset of metamorphosis ensues, allowing extra time for all discs to achieve their species-specific size and proportion. How exactly this exquisite coordination between growth and developmental timing is achieved is not completely understood. Recently, others and us have identified a fly-specific insulin/IGF-I/relaxin peptide named Drosophila insulin-like peptide 8 (DILP8) that responds to uncoordinated imaginal tissue growth and delays the onset of metamorphosis by inhibiting, via an unknown mechanism, the biosynthesis of the major insect molting hormone, Ecdysone. Loss of dilp8 increases intra-individual asymmetry and yields individuals with a greater than normal range of size variation and time of maturation. Thus, DILP8 is a central player in the communication system that mediates the adjustments to promote developmental stability in Drosophila. Here, we plan to identify the mechanism of action of DILP8 and to understand how this new peptide became incorporated into a conserved tissue-stress sensing pathway. To reach these objectives, we will identify the target tissue/s that mediate DILP8 function(s), the signalling pathway that it acts through, and determine when it originated and became responsive to abnormal growth during dipteran evolution. Our results should provide insight into the poorly understood physiological mechanisms used for interorgan growth coordination, and maybe shed new light into the evolution of new signalling pathways.

Keywords: developmental stability,tissue growth,metamorphosis,diptera,insulin-like peptide,relaxin,physiology,gene expression regulation,molecular evolution,hormone,cell signaling,reproduction
Risk-Sensitive Policy Making for Populations (RISK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-12-22
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The interest in risk analysis and management has increased in recent years. In particular, acknowledging the prevalence of uncertainty in the consequences of the decisions, foreseeing disastrous outcomes, and taking precautions against them has gained great importance. The project described in this proposal aims at dealing with these concepts in the context of problems that involve populations. Specifically, it will focus on revealing the effects of risk attitudes on dynamic population problems. Applications of special interest will be governmental decisions such as health and education benefits offered to individuals, criminal justice systems, counter-measures against natural disasters and terrorist attacks, sustainable use of natural resources, and management of epidemic diseases.

Keywords: policy making,risk aversion,uncertainty,populations,stochastic models,operations research,dynamic programming,game theory,risk management
Coalonialism: Energy and Empire before the Age of Oil (COALONIALISM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This is a multi-sited historical research into the geopolitical, social, and cultural implications of energy shifts during the long nineteenth century (1800-1911). Combining perspectives from archives in London, Istanbul, Cairo, and Jerusalem, I retrieve the so far ignored “age of coal” in the Middle East. Examining the mutually reinforcing role of British colonialism and fossil fuel extraction and proliferation, I aim to decenter Eurocentric understandings of industrialization by demonstrating the importance of colonial coal markets for financing Europe’s modernization and for providing overseas locations which prompted innovation in carbon-fueled technologies. Simultaneously, I concretize understandings of the power to colonize by following infrastructures like colonial coal-depots, steamer and rail lines. How is it possible, I ask, that English and Welsh coal facilitated the development of participatory forms of politics in England, while simultaneously solidifying authoritarian political structures when exported to a place like colonial Egypt? By following the different possibilities afforded by coal to English and Ottoman miners, coal-heavers in colonial ports, and to centralizing states reliant on newly-introduced transportation and communication technologies to control their populations, I will demonstrate how the different channels of coal propagation provided different kinds of leverage for historical actors. Finally, beyond coal’s significance in illuminating historical processes, it also reveals their ongoing implications in the present. In particular, it is impossible to understand the age of oil in the Middle East without attending to the colonial legacies of fossil fuels. As a historian specializing in the introduction of science and technology to non-Western settings, I propose to conduct four years of research to reconstruct these legacies, and eventually write the first book on the subject.

Keywords: history of science and technology,egypt,ottoman empire,coal,colonialism,oil