Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Emmtrix Technologies : European breakthrough in Software parallelization (EMMTRIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Emmtrix Technologies innovation offers an efficient solution to a global challenge faced by the automotive and many other industries where currently used embedded single-core processors increasingly reach their physical limits, and can no longer afford the computing power required for new applications like automatic parking, breaking etc. Leading processor manufacturers such as Intel, IBM etc. have recognized this trend and are aligning their strategy to use multicore processors. Within the next 3 years, the quantity of cores on a single chip is predicted to triple. Software parallelization is currently carried out manually and requires 3 times more software developers and 25% more time compared to single-core programming. The cost is 4.5 times higher. Manual parallelization is also highly error-prone. Emmtrix Technologies provides a software solution for the efficient, automated software parallelization for embedded multicore processors. Automated parallelization REDUCES the time and effort required to create a parallel program FROM MONTHS TO HOURS. Eliminating the need for manual programming, the Emmtrix solution reduces the development effort for software parallelization by up to 80% and leads to a higher quality final product. The automation allows even developers with less knowledge to quickly and efficiently develop and run parallel programs on the target hardware architecture. Emmtrix offers the first parallelization solution that efficiently supports programming languages which are already established in companies and allows for seamless integration into existing workflows. The market potential for the emmtrix solution corresponds to €1-2 billion worldwide as embedded systems are widely used in various industries, such as the automotive and supplier industry (Bosch), the automation industry (Siemens), consumer electronics (Apple), medical (Fresenius) and aerospace (DLR). In 2014, these industries generated a sales volume of $152.94 billion

Keywords: embedded multicore processors,parallelization
Craft work: Understanding the relationship between identity and work in the context of the future of work (CRAFTWORK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1152170.0
EU funding (EUR): 1152170.0
Participants: 1
Project status: SIGNED

The CRAFTWORK project is a multi-methodological, pan-European study that explores the relationship between identity and work in the context of the ‘new forms of work’ of the digital era. To do so, it focuses on the lived experiences, cultures and practices of ‘neo-craft’ work across different sectors and geographical contexts in the EU. The project investigates the subjectivities and pathways to work of ‘neo-craft’ workers, their perception of class location and their cultural conceptions of social status. At the same time, it questions the distribution of ‘neo-craft’ work across the urban-rural divide, and the role of social media in this context. The overarching goal of the CRAFTWORK project is to produce a new interpretative framework to understand the relationship between identity and work, that allows to account for the specificities of the ‘new forms of work’. Conceived as such, the project will significantly innovate and empower the critical study of the ‘new forms of work’ across different disciplines and research areas, and contribute to address the major societal challenge of the ‘future of work’. The project is ground-breaking for three reasons: a) empirically, it is the first comprehensive inquiry on ‘neo-craft’ work, currently hidden in existing data, in the EU area; b) methodologically, it experiments an innovative combination of digital methods and qualitative research for the study of work; c) theoretically, it aspires to provide a rethinking of the interpretative categories for the study of the relationship between identity and work in the context of a society transitioning out of the industrial era and into a fragmented scenario, whereby old and new forms of work coexist.

Keywords: new forms of work,identity,subjectivity,craft work,neo artisanal work,digital methods,hipster culture,creative labour,future of work
New tailor-made sizing strategies for recycled carbon fibres to improve the mechanical properties of polymeric and cementitious composites (CUSTOMISIZE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,France,France
Call: Sizing for recycled carbon fibres to optimise adhesion in organic/inorganic composite materials (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-12-31
Duration (months): 33.0
Total project cost (EUR): 499858.75
EU funding (EUR): 499858.75
Participants: 3
Project status: CLOSED

The CUSTOMISIZE project aims to develop a new family of carbon fibres’ sizing in order to improve the interfacial adhesion between recycled carbon fibre (rCF) and polymers (thermoset and thermoplastics) and cementitious matrices. The goal of this is to improve the strength, toughness and environmental stability of the composites prepared with the resized fibre. The specific sizing will be developed for non woven mat and chopped tow of recycled carbon fibres. The new upgraded recycled carbon fibre will be used to produce new composites with cementitious or polymeric matrices (thermoset and thermoplastic). The proposed strategy is the development of specific sizings for different polymeric and cementitious matrices through the incorporation of coupling agents along with the sizing materials, which through different mechanisms (covalent bond, hydrogen bond, Van der Waals interactions...) will create active points at the CF surface. Those will be responsible for chemical interactions with the matrix. New approaches as the use of Polyhedral Oligomeric Silesquioxanes (POSS), which consist of a rigid organic cubic silica-oxygen core surrounded by eight organic groups, will be used. CUSTOMISIZE also proposes to validate Steam Water Thermolysis, a current method to recycle CF, in the process to introduce chemical functionalities on the fibers that will be able to interact with the sizing. In addition, plasma viability will be studied due to its capability to create new chemical functionalities on fibers and also, the advantages that has compared to industrial electrochemical processes. It is expected to increase the interfacial shear strengths (IFSS) between rCF and the different matrices by up to 90%. A detailed Life Cycle Assessment (LCA) of the materials and processes will be carried out. These data will be used to assess the impact of the new sizing and its incorporation into different materials, and to support the success of the new developments in terms of sustainabil

Keywords: carbon fibre,sizing,recycling,thermoset,thermosplastic,cement,composites,mechanical reinforcement,aircraft structure
Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform (MICROX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-15
End date: 2022-09-14
Duration (months): 36.0
Total project cost (EUR): 281358.72
EU funding (EUR): 281358.72
Participants: 1
Project status: CLOSED

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

Keywords: hypoxia,melanoma,functional imaging,fret biosensors
Condition Monitoring of Wind Turbine Drive-Trains via Non-Contact Acoustic Sensors (CMDrive)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Italy,Spain,Greece,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-03-01
End date: 2019-05-31
Duration (months): 39.0
Total project cost (EUR): 2789131.25
EU funding (EUR): 2289732.88
Participants: 6
Project status: CLOSED

The EU Agency for Safety & Health is currently amending wind turbine standards (such as EN 50308) to ensure safer O&M tasks and increase the Probability Of Detection (POD) for wind turbine defects. ISO have also identified such issues, and in fact initiated the development of QA standards specifically tailored for the Condition Monitoring (CM) of wind turbines. Current CM systems are intrusive, and hence revoke the initial OEM warranty of drive-train components. The combination of industrial and legislative factors is the key driver behind the production of CMDrive: a bespoke and non-intrusive acoustic-analysis CM system, having a POD for drive-train defects of 90-98% within the range of operating powers. The requested grant of €2.5m will be required to validate and enhance the system, and initiate the commercialisation process. Growth in the wind services sector, as related to O&M and CM, is also compelling, as studies by Deloitte have shown that the corresponding market is estimated to increase from €5.2b to €10.8b by 2020, with a CAGR of 10%. The first generation of CMDrive shall be produced for wind turbines of 2.5MW or less; a next generation product, to handle larger turbines, has already been envisioned. The commercialisation strategy involves the segmentation of the wind turbine market into 3 initial customer tiers, is targeting WFOs and Independent Service Providers of CM within such tiers, and will position the product through a number of Unique Selling Points, which will be elaborated further in this proposal. The locations of the 5 partners, in addition to the global outreach of TWI and INESCO, are critical factors for launching the product by 2019. It is expected that CMDrive’s associated revenue streams (sales, services, licensing) will yield an estimated ROI of 1100%, and corresponding cumulative profits of €26m, over the 5 year forecast (2019–2023). INESCO will take lead of the sales, with the other partners benefiting by means of profit shares.

Keywords: condition monitoring,acoustic emission,non contact,wind turbine,drive train,operation and maintenance,non intrusive,probability of detection
Scenario simulations of the changing Black Sea ecosystem (SIMSEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-16
End date: 2017-06-15
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Marine modeling at JRC provides a tool to examine the present and future state of the marine ecosystem and can inform and support a variety of EU policies including the Marine Strategy Framework Directive. The Black Sea has suffered from severe ecological changes since the 1970s due to concurent effects of intense eutrophication, overfishing, outburst of gelatinous carnivores and natural climatic variations. The main purpose of the project is therefore to implement an advanced ecosystem model for the complex Black Sea ecosystem based on the validated JRC hydrodynamic model to generate future scenario simulations considering different policy options and climate change scenarios. The data generated from these scenario simulations will be thoroughly analysed using state of the art statistical methods like singular spectrum analysis and breakpoint detection methods. The results of this work will be broadly disseminated not only to the scientific community but it will be ensured that various groups, public bodies and agencies (e.g. the Commission on the Protection of the Black Sea Against Pollution, etc.), outside of academia can and will utilise the knowledge produced.

Keywords: ecosystem modelling,future scenarios,anthropogenic drivers,policy options
The role of tRNA processing and modifications in protein quality control. (MOD-PROT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 170764.95
EU funding (EUR): 159460.8
Participants: 2
Project status: CLOSED

Translation of the genetic code into functional proteins is a fundamental biological process essential for cell survival and function. tRNAs are critical in this process because they recognize the codons on the messenger RNA and bring the cognate amino acid to the nascent peptide. To become functional, tRNAs undergo a series of processing steps and chemical modifications. Recently, my host group discovered that cells lacking wobble uridine modifications in the tRNA anticodon display translational slow down, a defect that triggers widespread protein aggregation in yeast and nematodes. These findings were the first to link tRNA metabolism to protein quality control and established tRNA metabolism as a novel layer in the regulation of protein homeostasis. However, the mechanisms underlying this phenomenon remain unknown. My goal is to elucidate how tRNA processing and modifications regulate protein quality control, by integrating genetic, biochemical, transcriptomic, translatomic and proteomic approaches. - First, I will identify tRNA biosynthesis genes that are critical for protein aggregation, by assessing global protein homeostasis in yeast cells lacking genes required for tRNA processing and modifications. - Second, I will characterize transcriptome-wide translation by ribosome profiling to determine whether protein aggregation phenotypes are accompanied by translational defect. This will reveal which tRNA processing and modifications are essential for optimal co-translational protein folding. - Finally, I will use yeast and nematode models of neurodegenerative diseases to test the functional importance of candidate steps of tRNA metabolism in disease-associated protein aggregation. My project will comprehensively address the link between tRNA metabolism and protein homeostasis. In particular, it will bridge RNA and protein quality control pathways and shed mechanistic insights into neurodegenerative diseases that originate from tRNA dysfunction.

Keywords: protein homeostasis,translation,transfer rnas,protein aggregation,trna modification,trna processing enzymes,trna biosynthesis
Integrated Modelling and Analysis of Multiple Component Carbides in Welded hardfacings (NuWeld)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-01-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The proposed project aims to investigate the crystal/lattice structure and properties of multi-component carbides M7C3, and the mechanisms of carbide refinement in welded hardfacing process through integrated physical based predictive simulation and analysis. The main objectives: 1. To investigate the effects of different solution elements including RE elements on the crystalline/lattice structure and properties of primary M7C3 carbides using the first principle calculation. 2. To develop a new approach to predict the stable chemical compounds formed during the welding process of Fe-Cr-C hardfacings using ab initio evolutionary algorithm techniques and big data system; 3. To develop a new software and interface program to computerise the lattice misfit calculation in order to predict the probability of a compound formed in the welding process to act as the heterogeneous nucleus of primary M7C3 carbides and establish the carbide refinement mechanism. 4. To provide training on specific physical based predictive simulation and advanced analysis by the host and the project partner. This application is based on a novel approach to identify the chemical structure and properties of one most widely used carbides in the welding repair and maintenance process, leading to the development of a practical physical based simulation tool with potential scientific, industrial, economic and environmental impact in both the EU and worldwide. This programme offers an opportunity to cement collaboration between international award winning multidisciplinary research in the Host and partner organisations (Scientific Computing Department of the Science and Technology Facilities Council, several EU Universities and companies). If supported, this Individual Fellowship (IF) will significantly accelerate the development of the research skills and career of the ER, and will open up new areas of research and new external collaborations for the host with academics and industrial partners.
Hepatocytes-Like Microreactors for Liver Tissue Engineering (ArtHep)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2025-04-30
Duration (months): 72.0
Total project cost (EUR): 1992289.0
EU funding (EUR): 1992289.0
Participants: 1
Project status: SIGNED

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge. ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver. Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats. I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.

Keywords: enzyme mimics,encapsulated catalysis,cell mimics,liver,bioprinting