Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Descending control of pain (DescendPain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Pain is a large societal and health problem. Although often thought of as an invariant representation of active nociceptors, pain varies a lot under the influence of different affective states, sometimes with near complete analgesia. Such modulation of pain is thought to occur through a descending pathway originating in the brain and to be executed by Rostral Ventromedial Medulla (RVM) neurons that project to the spinal cord. Deciphering the complexity of the cell types involved and how they contribute to the descending control of pain has been challenging, but recent advances in single-cell omics, computational biology and advanced genetic technologies now open for unbiased system-wide insights. DescendPain will uncover the power of the brain to control pain. We will classify RVM neuron types by single-cell RNA-sequencing and use scRNAseq-based stimulus-to-cell-type mapping to identify neuronal ensembles conferring analgesia and hyperalgesia during morphine, naloxone, stress, sleep-deprivation and exercise. Using activity-based mouse genetics, we will reveal the full complexity of the combinations of neurons engaged and unravel their role in pain modulation, thus identifying for the first time the cellular basis for how affective states modulate pain. We will also use novel intersectional strategies for dual capturing of active neurons to determine how the descending RVM controls the transmission of pain in the ascending pathway of the spinal cord. Finally, we will identify the memory substrate underlying chronic pain, providing evidence for the existence of RVM neuron ensembles of chronic pain and revealing underlying cellular and molecular mechanisms. This project takes a new system-wide strategy in the pain field that should fundamentally change the view of pain, by providing a cellular basis for how it is continuously scaled by mental states and uncovering mechanisms of chronic pain, which may provide strategies for designing effective pain therapies.

Keywords: single cell rna sequencing,somatosensation,chronic pain
Expanding Digital Health through a pan-European EHRxF-based Ecosystem (XpanDH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Coordination and support actions
Countries involved: Portugal,Ireland,Belgium,Greece,Germany,Slovakia,Norway,Romania,Italy,Hungary,Netherlands,United Kingdom,Spain
Call: Setting up a European Electronic Health Record Exchange Format (EEHRxF) Ecosystem (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 1972310.76
EU funding (EUR): 1972260.75
Participants: 36
Project status: CLOSED

XpanDH is a CSA aimed at mobilizing and building capacity in individuals and organisations to create, adapt and explore purposeful use of interoperable digital health solutions based on a shared adoption of the European Electronic Health Records Exchange format (EEHRxF) across Europe. This pan-European effort will use a “network-of-networks” approach ensuring that digital health actors are motivated and supported by tailored guidance and real examples to help early adopters to advance to the concrete use of EEHRxF-embedded digital health solutions to add value to health and care and promote Personal and European Health Data Spaces. XpanDH pursues the main goal of maturing and accelerating a sustainable and scalable interoperability environment for digital health innovations based on the EEHRxF, around 5 Goals: 1) To develop robust technical specifications and resources for the EEHRxF building; 2) To establish the X-Bundle Readiness model; 3) To verify the usefulness of the X-Bundle in real-world with a set of early adopters grouped under selected adoption domains; 4) To mature a pan-European digital health ecosystem of solution providers and end-users, 5) To develop a framework for sustainable ecosystem. The consortium will thrive on past and ongoing eHealth interoperability projects and services, and particularly on the X-eHealth and DigitalHealthEurope projects recommendations, through digital health data activism and strong patient engagement. It brings together 26 Digital Health Actors under a co-creation and co-implementation concept, supported by a Policy Board (linking to Governments and the eHealth Network). To expand its impact, 10 XpandDH networks of hundreds of health stakeholders will be nurtured to form a vibrant pan-European (Digital) Health space converging on common, usable, and reliable tools for real interoperable services that adoption of the EEHRxF and enhance healthcare cooperation for better health towards a European Health Union.

Keywords: eletronic health record ecosystem standards computers health digital hospitals medicine patients data exchange colaboration networks,co creation
Double-Active Membranes for a sustainable CO2 cycle (DAM4CO2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Spain,Poland,United Kingdom
Call: EIC Pathfinder Challenge: Carbon dioxide and Nitrogen management and valorisation (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 2975275.0
EU funding (EUR): 2975275.0
Participants: 7
Project status: SIGNED

The exploitation of fossil fuels brought our ecosystem on the edge of catastrophic changes. Mankind’s current challenge is to reverse the increase of greenhouse gases emissions to mitigate the serious consequences on the global climate. In this scenario, the transition of modern society to a more sustainable and circular economy must be accelerated. One of the key pillars of this transition is the implementation of a sustainable CO2 cycle, based on net-zero emissions Carbon Capture and Utilization processes. Membrane-based technologies could play a pivotal role to bring this vision closer to reality. Indeed, thanks to their high efficiency, scalability, easy operability, they are candidates for the efficient capture and use of CO2. The goal of DAM4CO2 is to develop a novel membrane technology for the simultaneous CO2 separation and its photocatalytic conversion to C4+ molecules, as renewable fuels. DAM4CO2 will overcome the conventional membrane technologies by developing double active membranes (DAMs) with a durable and highly selective gas separation layer and a photocatalytic layer able to simultaneously combine in one pot reverse water gas shift (RWGS) and Fisher-Tropsch synthesis (FTS) to obtain C4+ molecules. The project will deliver a prototype, designed using the design-build-test-learn approach, for a proof-of-concept validation in lab-conditions. Close attention will be paid to the use of non-critical raw materials at every stage of the process, and the carbon-neutrality of the entire process will be certified by a full life cycle analysis. DAM4CO2 brings together the complementary expertise of our team in the areas of organic, inorganic and physical chemistry, materials science, and chemical engineering for the development, synthesis, and characterization of the starting materials, and for the design, construction, and application of membrane modules. DAM4CO2 will implement a sustainable, cost and energy effective net zero carbon CO2 cycle.

Keywords: gas separation membrane catalytic membranes,double active membranes,transport properties,catalytic properties,mixed matrix membranes,process intensification
A Framework for Modelling and Optimising the Resilience of the Integrated Natural Gas Production and Transmission Network System (ResilientGas)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-16
End date: 2027-07-15
Duration (months): 30.0
Total project cost (EUR): 215937.6
EU funding (EUR): 215937.6
Participants: 3
Project status: SIGNED

Natural Gas Production and Transmission (NGPT) network systems are vulnerable to (partial) failures, leading to natural gas supply disruptions and methane emissions, thus, calling for enhanced resilience. This project proposes to develop a novel framework for modelling and optimising the resilience of integrated NGPT network systems by employing Markov Decision Process (MDP) frameworks that identify optimal policies for system operation and maintenance. This novel approach allows for incorporating the dynamics of the system, including network topology and functionality changes upon operation and maintenance interventions; thus significantly improves on present-day practices. The MDP model is solved by Deep Reinforcement Learning (DRL) algorithms integrating a novel network capacity model developed using Graph Neural Networks (GNN). For illustration, I consider a European NGPT network comprising of offshore production platforms, subsea pipelines and onshore pipelines exporting the Norwegian gas to Europe. The project outcomes can be beneficial to gas producers and gas transmission operators whose optimal decisions contribute to more resilient natural gas supply for the benefit of Society. The success of ResilientGas hinges on advanced training on network resilience modelling, and on computational intelligence methods such as DRL and GNNs. I will thus need to compliment my own skills with a scientific tradition that is best studied with the team at Politecnico di Milano in Italy, where I will be under the direct supervision of Prof. Enrico Zio, whose research team is internationally recognised to lead the development of advanced tools and techniques for reliability, risk and resilience. A six-month placement in ARAMIS SRL (www.aramis3d.com), a cutting-edge R&D company, is foreseen to complement the research training with industrial practice and first-hand experience in deploying project outcomes, enabling me to position myself as a top researcher in this field.

Keywords: natural gas production and transmission,gas pipeline network,critical infrastructure,resilience modeling and optimization,sequential decision making,markov decision process
innovative Energy Storage TEchnologies TOwards increased Renewables integration and Efficient Operation (i-STENTORE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Luxembourg,Germany,Greece,Ireland,Portugal,Italy,Slovenia,Spain,Croatia,Belgium,Sweden
Call: Demonstration of innovative forms of storage and their successful operation and integration into innovative energy systems and grid architectures (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-04-30
Duration (months): 40.0
Total project cost (EUR): 9960565.23
EU funding (EUR): 8098455.43
Participants: 30
Project status: SIGNED

i-STENTORE will examine the integration of diverse storage solutions and their combinations. Innovative storage systems will be showcased and their co-operation with the integrated assets will be co-optimized, placing the reliability, the power quality, the cost-efficient operation and the maximization of the assets’ lifetime as end-goals. i-STENTORE will introduce an umbrella framework aiming to showcase stand-alone and hybrid storage solutions highlighting the multi-purpose use of storage, not only as an energy buffer, but also as an active grid component capable of providing services and contributing to grid resilience, stability and efficient operation. The proposed framework will examine the applicability of versatile storage solutions in various applications covering the mobility, agricultural, industry, household, heating and other sectors, and in different timeframes, creating what-if scenarios for the selection of the optimal storage solutions to serve each individual application in the most effective way, promoting purpose-specific Hybrid Energy Storage Systems (HESS). To achieve this and to ensure a seamless integration in a technology-agnostic and interoperable manner, i-STENTORE will design a Reference Architecture towards an open and flexible storage-enabling European energy system leveraging storage-induced flexibility and facilitating the increased integration of renewable energy sources (RES). i-STENTORE will embrace the introduction of novel business models, towards building positive and attractive business cases for storage, identifying new revenue streams for storage operators and promoting storage systems as a facilitator of the energy transition. This approach will develop and validate the enhanced connectivity of multiple systems at different levels of the energy value chain, incorporating both front-of-the-meter and behind-the-meter solutions, targeting the essential empowerment of new actors and the strategic shift of the role of storage.

Keywords: energy storage,hybrid storage systems,energy markets,business models,interoperability,standards,storage value chain,regulatory analysis
Leading the wave in the Food industry (Deniz)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EU prize
Destination: EU Prize for Women Innovators
Action type: Recognition Prize
Countries involved: Germany
Call: EIT Category (HORIZON-EIT-2023-WomenInnovatorsPrize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

I am Deniz, the founder and CEO of BettaF!sh, a company dedicated to pioneering a sustainable food revolution through the transformative power of seaweed. Our innovative approach not only disrupts traditional ingredient sourcing but also addresses pressing global challenges, including overfishing and climate-related risks. As an inspiring leader, I've actively engaged with the media, participated in interviews, podcasts, panels, and industry events, honing my confidence, presentation, and leadership skills. I have also mentored young talents and been recognized with prestigious awards, underscoring my commitment to leadership and entrepreneurship. Through my journey from humble beginnings to founding a thriving company, I aim to inspire and empower women and girls in pursuing their dreams. BettaF!sh's mission is not just about innovation; it's about setting an example and fostering a more inclusive and diverse food industry, making a positive impact for both people and the planet."
Enabling Autonomous Aerial Systems through Operational Methods and Technological Enhancements (EUSOME)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Greece,Poland,Serbia
Call: Excellence Hubs (HORIZON-WIDERA-2023-ACCESS-07, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 5998806.25
EU funding (EUR): 5998806.25
Participants: 16
Project status: SIGNED

The emergence of large drone systems that can be integrated with intelligent coordination technology has enabled Advanced Air Mobility (AAM) concepts that are poised to revolutionize a broad range of domains including transport (including logistics), and climate adaptation. Nevertheless, despite commendable global initiatives, Southeast Europe is facing challenges and delays in adopting and implementing AAM. In this context, we introduce EUSOME with the mission to propel the AAM R&I ecosystem in this part of Europe, addressing specific regional challenges arising from its distinctive geographical characteristics. Evidently, the region would heavily benefit from the development and adoption of a transformative transportation solution that has the potential to eradicate traffic congestion and provide a transformative climate adaptation solution to a heavily stressed ecosystem. Nevertheless, the incorporation of AAM presents regulatory complexities and lacks a driving force in terms of R&I in AAM, partly due to the absence of a cohesive, open R&I infrastructure and adequate specialized mentoring programs. The proposed EUSOME Excellence Hub endeavors to tackle these challenges head-on, assuming a pivotal role in establishing AAM as an integral component of the transportation landscape in the region. The consortium consists of experts across the whole AAM spectrum, from cutting-edge research departments, aircraft manufacturing, civil aviation authorities, relevant public agencies, experts in translating research into innovation, and representatives of the public society. This partnership enables EUSOME to deliver a diversified open R&I infrastructure, covering all needs within the AAM spectrum, a regional masterplan for the adoption of EASA’s recommendations on AAM, and a comprehensive mentoring, training, and service provider program for entities (businesses, public agencies, etc.) desiring to enter the AAM domain.

Keywords: advanced air mobility,u space,vertiports,autonomous aerial systems
Building a sustainable & circular economy through innovative, biobased manufacturing lines (NewWave)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Netherlands,Italy,Spain,Belgium,Slovenia,Switzerland
Call: Manufacturing technologies for bio-based materials (Made in Europe Partnership) (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-04-01
End date: 2026-03-31
Duration (months): 48.0
Total project cost (EUR): 5057580.0
EU funding (EUR): 5057580.0
Participants: 13
Project status: SIGNED

NewWave will contribute to building a circular economy by introducing sustainable raw materials in different manufacturing lines, replacing toxic chemicals and lowering the environmental footprint of the products. The raw materials are obtained from thermochemical fractionation of biomass. This process converts biomass residues by fast pyrolysis into Fast Pyrolysis Bio-Oil (FPBO). Subsequently, the FPBO is fractionated -based on chemical functionality- yielding a reactive lignin fraction and a sugar-rich fraction, both being excellent starting materials to produce sustainable, bio-based chemicals & materials. The selected product lines fully exploit the unique chemical functionalities already present in biomass residues and organic waste streams. Moreover, the lines are interlinked, and output from one line will further improve the sustainability of the other. Waste water treatment and water re-use is integral part of the concept. NewWave aims at wood-based products for the construction industry, including Cross Laminated Timber (CLT) to replace steel and concrete as structural components and modified wood to replace tropical hardwood or chemically treated wood for outdoor use. Medium Density Fibreboard (MDF) and plywood will be produced for interior usage. Toxic chemicals like formaldehyde and creosote will be replaced by non-toxic, bio-based alternatives. A small building will be constructed with these materials to demonstrate the products and test durability. The bio-based chemicals can also be used as green solvents, antifreeze & coolant and in the bulk & fine chemical industry. The European market potential is enormous (Billion ?/y range). The GHG emission avoidance ranges from 30% to over 90% depending on replacement ratio and end application. The individual manufacturing lines as well as the integrated value chain will be assessed in detail on technical, economic, social and environmental performance to ensure the production is truly sustainable.

Keywords: biomass,circularity,bio based products,pyrolysis,sustainability
Light on our dark past: Elucidating the deep archaeal roots of eukaryotic cellular complexity (DARK-ROOTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The origin of the eukaryotic cell, with its complex and compartmentalized features, represents a prime hallmark in the evolution of life on Earth. Yet, important details underpinning the emergence of cellular complexity of eukaryotic cells remain thus far unresolved. Current views support evolutionary scenarios in which the first eukaryotic evolved via a merger between an archaeal host cell and one or more bacterial endosymbionts. Recent phylogenomic work from my lab has shown that the archaeal host cell evolved from within the Asgard archaea, an archaeal clade uniquely displaying several eukaryote-like features. However, key aspects regarding the nature and biology of the archaeal host cell remain elusive, limiting our current understanding of the early stages of eukaryogenesis. In DARK-ROOTS, my team will capitalize upon our unique position and foundational results, and use complementary approaches to elucidate the emergence of complex cellular features during eukaryogenesis. Firstly, building on encouraging preliminary results, we will use an advanced anaerobic cultivation infrastructure to enrich diverse Asgard archaeal lineages. Next, we will use high-resolution and live microscopy approaches to study their cellular ultrastructures and cell biological properties. Furthermore, we will monetize on recent breakthroughs in structural biology and use AI-guided structural genomics to uncover new eukaryotic signature proteins in Asgard archaea. Finally, we will trace the evolution of Asgard archaeal proteins, focusing on homologs of proteins that give stature to the complex and compartmentalized nature in eukaryotic cells. Altogether, building on a rich foundation of preliminary results, my group will bring new pieces of the enigmatic eukaryogenesis puzzle to the table by elucidating how intracellular complexity arose during the prokaryote-to-eukaryote transition.

Keywords: eukaryogenesis,origin of the eukaryotic cell,archaea,genome evolution,microbial evolution,anaerobic cultivation,microbial cell biology,high resolution imaging,phylogenomics,ancestral reconstruction,structural genomics