Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generation of a Cell-Based Sialoglycan Array to Decipher Biological Interactions and Functions of the Human Sialome (Sialoglycan Array)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Human cells display a staggering repertoire of different sialic acid-carrying glycans (sialoglycans) at the surface - the Sialome. The Sialome regulates numerous biological processes including cell communication and migration and is involved in diseases such as infections , autoimmunity and cancer. However, most biological interactions and functions of the Sialome remain elusive, because suitable methods to address the Sialome as an ‘Ome’ and to dissect specific sialoglycan functions in the cell context are lacking. Therefore, I propose to generate a cell-based sialoglycan array for the display of all human sialoglycans in the natural context of individual glycoconjugates at the cell surface in an arrayable format. Using precision genome editing (CRISPR/Cas9) genes involved in sialoglycan synthesis will be targeted to create a library of isogenic human cells each displaying a unique part of the Sialome. These isogenic cells together form the cell-based sialoglycan array and will be used for high-throughput screening and discovery of binding specificities of sialoglycan-binding proteins such as Siglecs, selectins and factor H. Finally, the cell-based sialoglycan array will be used for the production of a representative panel of recombinant glycoproteins carrying homogenous N-linked or O-linked sialoglycans. The proposed research will take place at the at the Copenhagen Center for Glycomics a world leader in Glycomics and pioneer in precision genome editing in Glycobiology where I will be trained in precision genome editing, glycoengineering and state-of-the-art glycan mass spectrometry. Altogether, the cell-based sialoglycan array will be indefinitely sustainable, addressable by any multiplex assay, and serve as production platform for recombinant sialoglycoproteins. Ultimately, I expect that the proposed cell-based sialoglycan array will open the door for wide discovery of biological interactions and functions and of the human Sialome.

Keywords: glycobiology,sialic acids,sialome,glycome,precision genome editing
Adding Simulation to the Corporate ENvironmenT for Additive Manufacturing (Ascent AM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Integration of Laser Beam Melting Simulation in the tool landscape for process preparation of Additive Manufacturing (AM) for Aero Engine applications (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-08-01
End date: 2020-01-31
Duration (months): 42.0
Total project cost (EUR): 699375.0
EU funding (EUR): 699375.0
Participants: 1
Project status: CLOSED

The achievement of the Clean Sky 2 (CS 2) objectives, concerning the reduction of CO2 and fuel burn by up to 30 % as well as the reduction of NOX by up to 40 %, is strongly associated with the availability of innovative technologies and adapted structural design. Additive manufacturing (AM) is one of the key enablers and thus inalienable to reach these goals. First simple aero engine parts manufactured by AM-processes, like laser beam melting (LBM) have successfully been introduced into mass production. To use all possible benefits of the technology like e. g. design freedom, cost efficiency and a reduced time to market, first time right production is essential. One major issue are the distortions after production. Employing manufacturing simulation to support process development is a promising approach to realise first time right production. Current simulation models however, fail to calculate distortions within an acceptable time frame and do not respect post-processes such as stress relief annealing. Thus, the goal of this project is to integrate a suitable simulation-based process chain into the tool landscape for AM process preparation that enables a prediction of distortions with high accuracy in reasonable time to generate benefit for AM users. The main focus lies on the metal-based layered manufacturing process of LBM as this is the most widespread approach to generating three-dimensional parts from powder material.

Keywords: simulation,additive manufacturing,laser beam melting
Mathematics and Materials Science for Steel Production and Manufacturing (MIMESIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Finland,Norway,Finland,Finland
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 2110506.12
EU funding (EUR): 2110506.12
Participants: 6
Project status: CLOSED

The five partners EFD (Norway), SSAB, Outokumpu, and University of Oulu (Finland), and WIAS (Germany) propose an EID programme on Mathematics and Materials Science for Steel Production and Manufacturing, where eight PhD projects are jointly carried out, providing a unique interdisciplinary and inter-sectorial training opportunity. The research is focussed on three major topics - induction heating, phase transformations in steel alloys, ladle stirring. Two theses concern hardening: one is the hardening of helical and bevel gears by an optimized single or multi-frequency approach and the other is a novel idea about the hardening of the inner surface of pipes. Two of the theses are related to induction heating applications in the production of high-frequency welded pipes and for pre- and post-heating in the thermal cutting of steel plates. Two theses are concerned with phase transformations during steel production and the final two theses are related to secondary metallurgy in the ladle, optimal alloying strategies and an inverse problem related to stirring efficiency. Despite the fact that most theses projects deal with established processes, they are not fully understood nor fully controllable from a quality point of view. Improved and optimized process control requires quantitative mathematical modelling, simulation and optimization of the complex thermal cycles and thermal gradients experienced by the processed material. Such models require an understanding of the behaviour of the materials from a materials science and phase transformations perspective. Tailored industrial on-site trainings, customized courses in physical modelling and testing of steels as well as numerical simulation of induction heating and flow phenomena combined with scientific research in carefully selected topics on the interface of materials science and applied mathematics will provide the early stage researchers with excellent qualifications to pursue a career in academia or industry.

Keywords: mathematics,material science,induction hardening,induction welding,gradient wear,materials,multi field problems,optimal control
ProPeeler: Enhanced shrimp peeling machine with full control and optimisation of the process to enable full automation of the shrimp peeling industry (ProPeeler)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ProPeeler is an optimised peeling machine that will disrupt the current paradigm of the shrimp industry, one of the most popular seafood traded worldwide (20% of all seafood). Shrimp suppliers need solutions to increase their yields all while they reduce environmental footprint, improve the working conditions of their facilities, and ensure careful food safety and hygiene production while meeting growing demands. Automation has been one of the trends to respond to these growing pressures, evidenced by the fact that the processing equipment market is projected to surpass the €70 billion by 2022. Hand-peeling continues to dominate shrimp production since a stable electricity and water supply, high costs of upfront investment and fluctuating global market prices of shrimp continue to be barriers for the switch to automation. With 30 years of experience in the sector, Martak has led the development of innovative products for the cold-water shrimp segment, securing 60% of the market. ProPeeler, the most innovative edition of our peeling technology incorporates automated features of the machinery (direct drive mechanisms, unique water control system, improved uplift system and angle control mechanism) with real-time monitoring via a revolutionary vision control system that facilitates immediate intervention of the operator. ProPeeler allows shrimp producers to increase their yields, saves up to 70% of electricity and 20% of water usage. In addition, the return of investment can be expected within 6-7 months. Since ProPeeler is 20 years ahead of the current technology in the warm-water shrimp segment, it presents a real opportunity to enter a new market. Five years after ProPeeler market launch we plan to have penetrated the EU-Mediterranean countries, the US, South America and Asia. We have forecasted an accumulated revenue of €25 million in the five-year period after market launch and the creation of up to 10 new job positions
SkinFactory 2.0: GMP-in-a-box (SkinFactory 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Switzerland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-11-25
End date: 2020-11-24
Duration (months): 12.0
Total project cost (EUR): 183125.0
EU funding (EUR): 183125.0
Participants: 1
Project status: CLOSED

CUTISS AG is a Swiss start-up company that develops customized human skin autografts (denovoSkin™) for the treatment of large skin defects like burns and malformations. DenovoSkin™ possesses the right features to minimize scarring after transplantation and is currently in clinical phase II in Europe. While manual production of denovoSkin™ is sufficient in the development phase and clinical trials, automation of the manufacturing process is essential to scale the technology for larger demand and internationalization, and to be competitive with current standard treatments. The proposed recruitment of an Innovation Associate will have significant impact on the development of an automated system for the manufacturing of denovoSkin™ (SkinFactory 2.0), enabling production lines at industrial scale and around the world. The grant will help to overcome the recruitment barriers of being a relatively unknown, small start-up enterprise that cannot compete with larger companies due to limited visibility, brand awareness, (perceived) career opportunities, salary and recruitment budget. The translation of the manual production process of denovoSkin™ to an GMP-in-a-box automation platform requires the employment of a multi-disciplinary researcher that understands both the cell biology and complex requirements of tissue engineering as well as the mechatronics and industrial design of automation. The envisaged Innovation Associate has to bring a multidisciplinary set of skills in to CUTISS and will have the opportunity to become an expert in the emerging field of bio-engineering. It is in the interest of the company to continue the employment after the initial year in order to develop the delivered prototype into an industrially producible end product. Successful market introduction of SkinFactory 2.0 will put CUTISS in the forefront of a new, emerging field of automated production of personalized, bio-engineered tissue, which is expected to change medicine radically.

Keywords: innovation associate,tissue engineering,automation
From Land to Water: the Role of Development in the Evolution and Diversification of Baleen and Toothed Whales (Evo-Devo-Whales)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-07
End date: 2022-09-06
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Cetaceans (baleen whales and toothed whales) are a distinctive group of mammals that has evolved unique adaptations to live in water. Their impressive fossil record traces their evolution from their terrestrial ancestors (Artiodactyla), to the present aquatic forms. All living cetaceans have flippers instead of limbs, possess a blowhole at the top of the head instead of an anteriorly-positioned nose. They have also developed a characteristic head shape connected to their feeding mode: while baleen whales have lost their teeth and feed using keratinous plates called baleen, toothed whales have evolved the ability to locate their prey using sound waves (echolocation). Changes in prenatal development (ontogeny) played a major role in allowing these animals to evolve the skull adaptions they currently display related to their peculiar traits. Though, little information is available on their development, limiting our understanding of the role of ontogeny in the evolution of modern cetaceans. This project aims to apply 3-dimensional (3D) imaging and cutting-edge geometric morphometric (GM) and phylogenetic methods to quantify the ontogeny of the skull in a diverse sample of cetaceans and terrestrial artiodactyls in order to reconstruct how development has shaped the evolution and diversification of this unique group of mammals. This project will produce high-quality 3D datasets that will be shared in on-line repositories, making rare fetal specimens of toothed and baleen whales accessible for further research and for outreach initiatives. The project will benefit from the expertise in GM methods of a world-renowned researcher and her team, and the vast collection of specimens available at the host institution. Through this fellowship, the researcher will be reintegrated in the European scientific community and master key skills to then start her independent career. She will learn new methodologies, while strengthening transferrable professional skills.

Keywords: evo devo,evolution,development,cetacea,mammals,geometric morphometrics,phylogenetic methods,diversification,environment,ecology
Hybrid Optical Interferometry for Quantitative Cancer Cell Diagnosis (OptiQ-CanDo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2022-12-31
Duration (months): 78.0
Total project cost (EUR): 1916250.0
EU funding (EUR): 1916250.0
Participants: 1
Project status: CLOSED

A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this research project is to establish a robust experimental toolbox for label-free optical diagnosis and monitoring of live cancer cells in-vitro and their potential of metastasis. Optical interferometry is able to provide a platform for imaging live cells quantitatively without the risk of effects caused by using external contrast agents. By overcoming critical technological barriers, I suggest novel hybrid optical interferometric approaches that provide a powerful nano-sensing tool for label-free quantitative measurement of cancer cells. This will be obtained by recording the dynamic quantitative, three-dimensional sub-nanometric structural and mechanical characterization of live cancer cells in different stages. For this aim, I will develop a novel low-noise broadband, common-path, off-axis interferometric system for sub-nanometric physical thickness and mechanical mapping of live cells in thousands of frames per second. Additionally, I will develop rapid tomographic approach for fully capturing the cell three-dimensional refractive-index distribution, as a tool to characterize cancer progression. Interferometry will be combined with multi-trap holographic optical tweezers and dielectrophoresis to enable complete cell manipulations including full rotation, imaging of non-adherent cells, and mechanical measurement validation. New set of interferometry-based quantitative parameters will be developed to enable characterization of cellular transformations, and used to characterize cancer cells with different metastasis potential, for cell lines and for circulating tumor cells.

Keywords: interferometric microscopy,digital holographic microscopy,quantitative optical cell imaging,label free cell imaging
MOMENTUM - virtual, mobile CFO for small and medium enterprises (MOMENTUM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MOMENTUM is a virtual and mobile CFO platform fthat helps Small and Medium-sized Enterprises (SMEs) ensure financial liquidity and growth on EU market. MOMENTUM is an innovative online and mobile platform for registered SMEs. The Platform can be accessed on mobile platforms (iOS and Android), as a separate SaaS (Software as a Service) on the Atsora website or directly from the bank website (as an extension of electronic banking). The most important features of MOMENTUM platform: 1) seamlessly integrated with bank account, online accounting and other SaaS business applications in order to provide real-time view on business and help with day-by-day decisions 2) simplifing business planning, budgeting, forecasting and performance tracking for small businesses and startups 3) enabling user to set business goals, compare performance to industry benchmarks and see all key numbers in an easy-to-use dashboard, so he knows exactly what's going on in his business The Platform integrates together SMEs and business partners (banks and other medium and large enterprises providing a wide spectrum of services and products to the SME segment). Integration with banks is an important part of the system. The entrepreneur can decide to provide more information about his business to the bank and receive thereby easier access to finance on potentially better conditions. Therefore, the result of the implementation MOMENTUM platform on the European market will be facilitated access to finance for SMEs. In the opinion of the applicant, use of the proposed application should improve conditions for the implementation of new technological, organizational and marketing actions, which is contributing to meeting the objectives set by the EU to stimulate innovation activities of SMEs.

Keywords: online and mobile platform for smes,cashflow,business model and sales pipeline tools,collection of the most important data in real time and in one place
The Divine Tragedy of Securing the Sacred: Religion, Security and Nationalism in Southeast Asia (SeReNa-SEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The rise of religiously inspired extremism and violence, particularly since 9/11, has underscored the crucial and abiding three-way linkages between security, religion, and nationalism (hereafter, SRN). While much emphasis has been placed on Islam and the Middle East, the research proposed here pioneers the study of security policies and strategies, dominant and marginalised religions, and conceptions of national identities in Southeast Asia, by comparing the predominantly Catholic Philippines, Islamic Indonesia, and Buddhist Myanmar. Using a qualitative, comparative approach, the ER will theorize and produce new empirical knowledge about: (a) why and how states utilize religion when formulating and implementing their national security policies and strategies; (b) how security considerations influence the utility and status of religions, particularly the (often negative) impact on religious minorities; and (c) how nationalism is used to institutionalize and legitimize religiously-infused national security rhetoric and agenda. In answering these questions, emphasis will be placed on how (a) the gender hierarchy inherently present in these three major religions; (b) the gendered complexion of violence in security operations; and (c) gendered conceptions of nationalism influence the nature and outcomes of SRN linkages. Before extensive fieldwork, the ER will undertake training in research methods and management, pedagogy, and knowledge transfer. Planned activities will disseminate knowledge to academic communities, while a 3-month placement with an international think tank will enable the ER to directly inform policy debate. Combined, the programme of training, research and dissemination will enable the ER to secure permanent employment at a leading university.

Keywords: religion,security,southeast asia,philippines,indonesia,myanmar