Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable Environmentally-friendly Advanced-Composite Zero-Emission Boats (SEABOAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Ireland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-03-01
End date: 2020-08-31
Duration (months): 30.0
Total project cost (EUR): 2350000.0
EU funding (EUR): 1645000.0
Participants: 2
Project status: CLOSED

The SEABOAT concept will tackle inherent issues in the recreational boat manufacturing industry, with a particular focus on addressing outdated, inefficient, costly and environmentally inferior hull-manufacturing processes that will not meet new legislation. It will also address the demand by recreational boat users for improved performance and sustainability advantages, comparable to those delivered by electric cars. In response, SEABOAT will deliver significant positive impacts in terms of industry/EU competitiveness, scalable company growth in revenue & jobs, and a wide array of performance & environmental benefits. This will be achieved by commercialisation of the Composite Powder Epoxy Technology (C-PET) manufacturing process within the recreational boat manufacturing segment and by introducing a revolutionary E-Boat design incorporating the C-PET manufactured hull into the market, enabling ÉireComposites (composites manufacturing technology expert) to achieve in excess of €45m cumulative revenue and 260 jobs from 2021-2023. Originally conceived for aerospace/renewable energy applications, C-PET is a high-performing, cost-effective manufacturing technology that will lower the cost of boat hulls by 30%, eliminate toxic Volatile Organic Compounds & reduce hull weight by 45%. Reduced hull weight will allow extra batteries and enhance boat range/performance, so that for the 1st time ever, battery-powered boats will be able to compete with fuel-powered alternatives. C-PET will be demonstrated & tested in an advanced electric boat, reducing operational costs by 60% & delivering 0 emissions, with tangible benefits along the whole life-cycle. SEABOAT will enable wider adaptation of electrical boats (replacing fuel powered engines), helping drive growth in the market for electric boats estimated to achieve global worth of $20bn by 2027 and rejuvenate peripheral, coastal economies.

Keywords: blue growth,e boat,advanced materials,environmental performance,zero emissions boats,weight reduction,cost reduction,innovative manufacturing,sustainable boat building
Laser-Assisted Surgical System to Revolutionize Cardiac Bypass Surgeries (SAFE-CAB)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Switzerland,Switzerland,Netherlands,Netherlands
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-09-01
End date: 2023-06-30
Duration (months): 46.0
Total project cost (EUR): 2850312.5
EU funding (EUR): 2182118.75
Participants: 6
Project status: SIGNED

Coronary Artery Bypass (CAB) surgery is performed annually in >700,000 patients to treat coronary artery disease and prevent myocardial infarction (heart attack). Standard CAB surgery involves a highly invasive open-heart procedure in arrested/non-beating heart, that is associated with long recovery times and severe complications. The surgeons are seeking for less invasive, closed chest CAB procedures on beating heart, but current solutions are technically extremely challenging and thereby only used in <1-3% of all surgeries. The vision of the SAFE-CAB consortium is to make the minimally invasive CAB surgeries available to all surgeons as a novel standard of care, thereby substantially improve patient outcomes and reduce health care costs. The goal of the project is to bring to market a first-of-its-kind laser-assisted minimally invasive surgical system (surgical kit containing surgical implant and laser catheter). SAFE-CAB enables minimally invasive procedure on beating heart, without the need for arresting blood flow or complex hand suturing. With shorter recovery times, less complications and improved survival rates in high-risk patients, the SAFE-CAB technology has a potential to replace high-risk open-heart surgeries. Replacing only 15% of open-heart surgeries in Europe and US translates to annual market opportunity of >€89M and >€192M. Dutch SME AMT Medical has developed the proprietary SAFE-CAB technology to clinical readiness. To substantially accelerate the market entry of the product, the company partners with a leading European cardiac surgery hospital Deutsches Herzzentrum Berlin and a pan-European clinical/regulatory medical device company HEMEX to obtain regulatory approval through final clinical validation . To realize European wide-implementation, the consortium is complemented by a surgery training company LifeTec Group and the oldest professional organisation for cardiac surgeons European Society of CardioVascular and Endovascular Surgery.

Keywords: surgical implant,medical device,cardiac surgery,coronary artery bypass surgery,minimally invasive bypass surgery,clinical trial,surgical training platform
High Performance Bio-based Functional Coatings for Wood and Decorative Applications (PERFECOAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Estonia,Germany,Germany,Germany,Ireland,Norway,Türkiye,Norway,Norway,United Kingdom,Denmark
Call: Improve the sustainability of coatings (H2020-BBI-JTI-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 6250541.25
EU funding (EUR): 4999567.5
Participants: 13
Project status: SIGNED

Achieving a climate-neutral Europe by 2050 requires the replacement of fossil-based material with bio-based material on a broad basis. Today, ca. 900 kt/y paints and coatings are produced in Europe, with more than 80% still being from fossil resources. Wood and decorative coatings represent a large market, accounting for more than half of that volume. The goal of the PERFECOAT project is to develop and validate a new generation of industrial wood and decorative coatings with significantly more than 25% bio-based components that meet and even surpass the current quality and sustainability standards. Our concept is based on a flexible platform of novel technologies to produce and functionalize new, bio-based bulk coating components and assemble them into new coating formulations. Three major coating markets will be addressed: 1) high-volume ultraviolet (UV)-curable clearcoats, 2) do-it-yourself (DIY) waterborne trim paints, and 3) DIY waterborne wall paints. End-of-life scenarios plus economic, environmental, and social assessments will support the technological development in PERFECOAT, to guarantee a high level of sustainability throughout the value chain. The coating ingredients and final coating blends produced by PERFECOAT will be tested for safety compatibility at different stages of their development. High performance of new advanced bio-based binders, fillers and additives will be systematically developed and validated in coatings, starting from a proof of concept (TRL3) to demonstrator validation (TRL5). PERFECOAT is implemented by a strong, well-balanced, multidisciplinary consortium of experts from 4 universities and research institutes and 8 commercial project partners, including 4 SMEs, in 7 member countries. All partners are committed and highly motivated to jointly increase the competitiveness and sustainability of European industry by bringing innovative materials and methods closer to the marked while fostering new cross-sector interaction.

Keywords: biopolymers,renewable feedstock,bio based binders,uv curable coatings,waterborne coatings,industrial biotechnology
Dead or Alive: Finding the Origin of Caldera Unrest using Magma Reservoir Models (DEFORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 201133.92
EU funding (EUR): 201133.91999999998
Participants: 2
Project status: CLOSED

Caldera-forming volcanic eruptions can have severe impacts from the local to global scale. As vast quantities of magma are ejected during the eruption, they can trigger deadly pyroclastic density currents and lahars, release noxious gases and even alter global climate. At many calderas, episodic unrest in the form of pronounced uplift, increased seismicity and elevated gas emissions raise concern over the potential for such destructive eruptions. However, it remains difficult to ascertain whether the unrest observations indicate (1) an injection of new magma into the crustal reservoir, which could increase its potential for explosive eruptions, or (2) a sudden release of magmatic volatiles from a cooling and crystallizing reservoir, which would remain unlikely to erupt explosively. In this proposed project, I will develop a physics-based model of a magma reservoir to determine the processes involved in magma injection and evolution that may lead to episodic unrest. Of particular interest is how gases migrate through the system and alter reservoir volume. The model will simulate the thermo-mechanical evolution of a two-dimensional, three-phase (solids, liquids, gas) magma reservoir. By leveraging emerging continuum frameworks for reactive transport modelling, this work will expand existing two-dimensional models to simulate three phases in varying proportions in a computationally efficient approach. The reservoir model will be coupled to ductile-to-brittle crustal deformation to understand the conditions that lead to episodic unrest. I will compare simulation results with time series observations of ground deformation and gas emissions from Laguna del Maule in Chile, thought to be undergoing magma injection, and Long Valley in the US, thought to have experienced punctuated gas release. Results will bridge the gap among current models of three-phase magma dynamics and will improve understanding of the eruption hazard implied by caldera unrest.

Keywords: computational geoscience,fluid dynamics,multiphase flow,continuum mechanics,thermodynamics,magma reservoir dynamics,crustal deformation
Polymeric Membranes for Artificial Endosymbionts (PolyMAE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-04
End date: 2023-05-03
Duration (months): 24.0
Total project cost (EUR): 179313.34
EU funding (EUR): 179313.34
Participants: 2
Project status: CLOSED

Synthetic biology has constantly been expanding its reach, aiming to develop whole genetic circuits and metabolic pathways, which require laborious genetic engineering. Often, such pathways derive from other organisms and must be tweaked to fit the host’s molecular biology, adding to the complexity of the task. However, nature has already witnessed the integration of whole prokaryotic organisms into eukaryotic hosts, where they are integrated as endosymbionts creating new combinations that live with mutual benefit. In evolutionary history, this phenomenon was at the origin of organelles such as mitochondria and chloroplasts, which added their own metabolism to their hosts. To achieve a more generalized framework, where any prokaryote can enter endosymbiosis with any eukaryote, we need to induce the uptake and retention of the guest by the eukaryotic host. A way forward will be by masking the guests with biocompatible polymers, either pre-formed, or synthesized by the bacterium itself. The project proposed herein offers a novel technique for the the encapsulation of prokaryotes into biocompatible shells, creating a new strategy for the straightforward production of bio-orthogonal, artificial endosymbionts. After the formation of the polymer shell around bacteria, they will be endocytoted by eukaryotes, thus expanding the biochemical potentialities of cells, revolutionizing the possibilities of synthetic biology, acting as true artificial organelles. This breakthrough will allow the functional insertion whole genomes into the host cells and the combination of micro-organisms, which will have implications in medicinal, industrial and environmental biotechnology. It will lead to the creation of complex, semi-synthetic hybrid organisms able to perform a vast variety of non-natural biotransformations. In line with the 2020 Work Programme, it will open up several diverse possibilities that will benefit European and global industries.
Advanced signalling and automation system - Completion of activities for enhanced automation systems, train integrity, traffic management evolution and smart object controllers (X2Rail-4)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Italy,Italy,Italy,Italy,Germany,Sweden,Switzerland,Switzerland,Belgium,Poland,Slovenia,Sweden,Sweden,Sweden,Sweden,Belgium,France,France,France,Czechia,United Kingdom
Call: Completion of activities for enhanced automation systems (including Freight ATO GoA4), train integrity, object controller (IP2 and IP5). (H2020-S2RJU-CFM-2019, 2019)
Start date: 2019-12-01
End date: 2023-12-31
Duration (months): 49.0
Total project cost (EUR): 24470112.44
EU funding (EUR): 17900872.53
Participants: 38
Project status: SIGNED

X2RAIL-4 is the 4th project of the Shift2Rail members in the IP2 “Advanced Traffic Management & Control Systems” domain and it aims to continue the research and development of key technologies within the following Technology Demonstrators (TDs): -Railway line capacity increase (ATO up to GoA4)–TD2.2 (WP3, WP4, WP5): Finalize the activities started in X2Rail-1 by completing the GoA2 Specification. Develop ATO GoA4 prototypes. Integrate and test Obstacle Detection devices and “environment sensors” in cooperation with IP5 TD5.1.3. -On-Board Train Integrity–TD2.5 (WP6, WP7): Finalize the activities started in X2Rail-2. Define, develop and test complete On-Board Train Integrity system prototypes able to be applied in every train typology (i.e. Passengers and Freight trains with wired and wireless communication). -Traffic Management Evolution–TD2.9 (WP8, WP9, WP10): Finalize the activities started in X2Rail-2. Define, develop and test various elements of a Traffic Management System platform. Define and design a communication platform (Integration Layer) using standardized data structures and processes to manage the Communication/Data exchange between different services/clients and supporting TMS applications connected to other multimodal operational systems. -Smart radio-connected all-in-all wayside objects–TD2.10 (WP11, WP12): Finalize the activities started in X2Rail-1.Develop, implement and validate technical demonstrator. Develop and test prototype providing data exchange between trackside equipment and signalling devices via wireless connection; reduction of required cabling; increase on the availability of Maintenance Data, reduction of maintenance costs; support to preventive maintenance.

Keywords: shift2rail,innovation programme 2,automatic train operation,on board train integrity,traffic management evolution,smart object controller,demonstrator,prototype
Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia (RECOGNISED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Italy,Belgium,Belgium,Netherlands,Netherlands,Montenegro,Denmark,United Kingdom,Portugal,Luxembourg
Call: Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 5998272.5
EU funding (EUR): 5998272.5
Participants: 25
Project status: SIGNED

In recent years there is mounting evidence that type 2 diabetes (T2D) is associated with cognitive impairment and dementia, which can be considered as a “new” long-term diabetic co-morbid complication with dramatic consequences for patients and their families and a significant impact for healthcare systems. At present there are no reported phenotypic indicators or reliable tests to identify T2D patients at risk of developing dementia. Since the retina is ontogenically a brain-derived tissue, we propose that the evaluation of retinal parameters related to either neurodegeneration or microvascular disease will be robust and valuable biomarkers to identify those T2D patients at higher risk of developing cognitive impairment and dementia. On this basis the overarching aims of the project are: 1) To investigate the common mechanisms involved in the pathogenesis of DR and cognitive impairment in the T2D. 2) To use the retina as a tool to identifying individuals with T2D at a higher risk of developing cognitive decline or dementia. Our multidisciplinary consortium (RECOGNISED) consist of top research leaders in the field belonging to 15 prestigious institutions as well as EATRIS, IDF-Europe and Alzheimer Europe and 3 SMEs. RECOGNISED will apply innovative approaches to identify the molecular mechanisms involved in the high prevalence of cognitive impairment and dementia in T2D population and will use this knowledge to characterize clinical phenotypes (personalized medicine) based on retinal functional and structural characteristics and serum biomarkers in order to stratify the risk and severity of cognitive decline. Previously collected data from registries, cohorts and biobanks will be appropriately exploited and robust new data will be generated that will guide clinical recommendations and open up new therapeutic strategies. Ultimately, RECOGNISED project will help to reduce the huge societal and economic burden associated with diabetes-related cognitive impairment.

Keywords: diabetes mellitus,diabetic retinopathy,cognitive impairment,dementia,alzheimer disease,diabetes related comorbidities,neurodegeneration,mechanisms of action,clinical phenotypes
Targeting the transcriptional landscape in infant AML (iAML-lncTARGET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Germany,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-06-01
End date: 2023-06-30
Duration (months): 73.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 605645.0
Participants: 3
Project status: SIGNED

Infant acute myeloid leukemia (AML) has a dismal prognosis, with a high prevalence of unfavorable features and increased susceptibility to therapy-related toxicities, highlighting the need for innovative treatment approaches. Despite the discovery of an enormous number and diversity of transcriptional products arising from the previously presumed wastelands of the non-protein-coding genome, our knowledge of non-coding RNAs is far from being incorporated into standards of AML diagnosis and treatment. I hypothesize that the highly developmental stage- and cell-specific expression of long non-coding RNAs shapes a chromatin and transcriptional landscape in fetal hematopoietic stem cells that renders them permissive towards transformation. I predict this landscape to synergize with particular oncogenes that are otherwise not oncogenic in adult cells, by providing a fertile transcriptional background for establishing and maintaining oncogenic programs. Therefore, the non-coding transcriptome, inherited from the fetal cell of origin, may reflect a previously unrecognized Achilles heel of infant AML, which I will identify with my expertise to understand and edit the AML genome and transcriptome. I will apply recent breakthroughs from various research areas to i) create a comprehensive transcriptomic atlas of infant AML and fetal stem cells, ii) define aberrant or fetal stage-specific non-coding RNAs that drive leukemia progression, and iii) resolve their features to probe the oncogenic interactome. After iv) establishing a biobank of patient-derived xenografts, I will v) evaluate preclinical RNA-centered therapeutic interventions to overcome current obstacles in the treatment of infant AML. Targeting the vulnerable fetal stage-specific background of infant AML inherited from the cell of origin may set a paradigm shift for cancer treatment, by focusing on the permissive basis required by the oncogene for inducing and sustaining cancer, rather than on the oncogene itself.

Keywords: infant,long non coding rna