Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mutation rate determinants across cellular and evolutionary scales (Mut-Scales)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1489760.0
EU funding (EUR): 1489760.0
Participants: 2
Project status: SIGNED

As individuals age, mutations accumulate inexorably in their cells, playing a key role in evolution, ageing, and disease. Despite their importance, we still have a poor understanding of how mutations originate, or why some cells accumulate more mutations than others. This proposal aims to address these fundamental questions by examining two axes of mutation rate variation: among cell types and across species. In Aim 1, we will decode the rules of germline mutation during mammalian spermatogenesis. Cells in the germline exhibit mutation rates significantly lower than those in the soma, through mechanisms that remain unknown. Leveraging recent breakthroughs in long-read DNA sequencing, we will track the accumulation of mutations from spermatogonial stem cells to mature spermatozoa in mice. By integrating this data with existing cell type-specific profiles of gene expression, epigenetic marks, and chromatin architecture, we will delineate how cellular processes influence mutation rates in the germline, aiming to reveal differences with patterns in the soma. In Aim 2, we will characterise the DNA damage response across primates. Recent findings suggest that longer-lived mammals have lower somatic mutation rates, but the underlying mechanisms remain elusive. To tackle this question, we will experimentally expose primary fibroblasts of ten primates to UV radiation and a promoter of oxidative stress, quantifying the impacts on cell viability, gene expression, genome accessibility, and mutation rates and spectra. With this comprehensive approach, we will disentangle the pathways leading to damage-induced mutations, as well as uncover molecular mechanisms that evolution has wielded to select for healthier, longer-lived primates. In summary, this proposal aims to learn about how mutations occur—that is, how they originate mechanistically—as well as why their rate of appearance differs across cell types and species—namely, what selective pressures drive mutation rate evolution

Keywords: mutation,germline,dna damage and repair,primates
Integrated process for seawater electrolysis using a PGM-free anion exchange membrane stack (ASTERISK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Ireland,Italy,Israel,United Kingdom,Spain,Germany,Slovenia,Switzerland
Call: Development of innovative technologies for direct seawater electrolysis (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4393169.71
EU funding (EUR): 3973258.1
Participants: 12
Project status: SIGNED

ASTERISK proposes integrating seawater treatment and green hydrogen production using a Platinum Group Metal (PGM)-free anion exchange membrane (AEM) electrolyser. The consortium will work on developing AEM stack components compatible and stable under saline conditions, namely water oxidation and water reduction electrocatalysts, anion exchange ionomers and membranes, porous transport layers and electrical contacts. ASTERISK will incorporate a minimal seawater treatment step before the stack to remove biological, organic and suspended solids content with minimal energy requirements and operating costs, leaving the ions naturally present in seawater to enter the stack. The project will meet the challenging KPIs set by this call and significantly improve upon the degradation rate of <5% over 500h operation leveraging the current experience on materials and membranes design already developed in ongoing projects involving several ASTERISK partners. A final ASTERISK demo will achieve up to 100 gH2/h production on a 5 kWe stack operating for 2000h, to achieve the goal of reaching TRL 4 at project end. The technical work will be complemented with an eco-design process supported by an environmental and socio-economic analysis to guide the development of a low impact and circular designed AEM device maximising socio-economic benefits. A techno-economic and exploitation plan to move from laboratory scale single-cell to a multi-stack electrolyser will be studied to ensure a fast-track to commercialisation. If successful, ASTERISK will advance cost-effective and sustainable green hydrogen production and contribute to the European Union's long-term carbon neutrality and renewable energy leadership goals.

Keywords: seawater electrolysis,water splitting catalyst,anion exchange membrane,stack design and testing
Diagnose Alzheimer’s disease with isotopes (DAI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

During the course of the PRISTINE proposal we have developed the first high precision high sensitivity stable isotope measurements for a variety of vital elements, including Zn, and Cu . With these technical advances we realized that we could monitor stable isotopic changes within organisms that open up a new way to study metal homeostasis as well as a new ways of detection diagnosis for diseases, in particular the Alzheimer's disease. In DAI, we will further explore make use of these unique technical advance to demonstrate the feasibility of using stable isotope geochemistry of metals to detect the early stages of the Alzheimer's disease. to reach this goal, we will combine our technical skills developed during PRISTINE with medical science to demonstrate this proof of concept and if succesful to file a patent. This would represent a unique way to apply isotope cosmochemistry to medical science fields.
Engineering biological signaling pathways using synthetic cells (SIGSYNCELL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Netherlands,Germany,Slovenia,Singapore,Denmark,United Kingdom,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2672589.6
EU funding (EUR): 2672589.6
Participants: 15
Project status: SIGNED

Facing the challenges of the XXIst century related to climate, energy and health requires the development of new biotechnologies. Synthetic approaches of biology represent an opportunity for applications where living cells are inefficient, inadapted or undesired. Yet, ‘Only cells can make cells’ remains to date an unrefutable fundamental reality and constructing de novo living systems represents the new frontier of biotechnology. The IT industry developed over the years highly complex and integrated microsystems, based on building blocks such as the transistor and fundamental principles of electrodynamics and quantum physics. The analogon for biology must still be unraveled to develop the biotechnologies of the next century. Our aim is to produce life-like systems of synthetic cells in interaction with their environment. We will train Doctoral Candidates to develop a toolbox of experimental building blocks, based upon soft microcompartments, molecular transporters, DNA nanotechnologies, optical technologies and microtechnologies, for the construction and integration of large population of interacting synthetic cells. Because they are built from scratch with a high-level of functional characterization and control, these cells will allow to unravel fundamental principle in life complexity and, at the same time, become integrable building blocks - analogon of the transistors of the IT industry - of a new type of biotechnology. They will pave the way for applications of synthetic cells addressing the pressing needs of the XXIst century, in energy harvesting, biomass and raw matter transformation, bio-remediation or therapeutics. Our network based upon interdisciplinarity in research and innovation, will train the next generation of independent and responsible scientists to address pressing global challenges through the build up of fundamental knowledge and sustainable innovations.

Keywords: artificial cells bottom up synthetic biology dna nanotechnology light responsive systems microfluidics molecular sensing active matter dna origami
Neuroregenerative peptide treatment for multiple sclerosis (REGENERA MS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

REGENERA MS will assess the technical and commercial feasibility of a novel peptide as a superior treatment for multiple sclerosis (MS). Successful commercialization of our peptide could reduce the socioeconomic burden of MS, provide an early-therapy option to delay disease progression and thus extend and improve patients’ lives, with potential effectiveness in related neurodegenerative diseases. MS is a chronic inflammatory, autoimmune, and neurological disease without a cure, affecting the lives of 1.2M Europeans and causing significant economic costs to patients and society. Currently, there is no cure for MS. Approved disease-modifying treatments such as IFN-β1, glatiramer acetate and alemtuzumab are clinically effective but come with high costs, significant side-effects, and intrusive administration. Thus, a medical unmet need remains for novel MS therapies that can halt progression, promote myelin repair and limit complications. To improve on the current therapeutic regimen, we propose a next-generation neurotrophic factor (NTF) therapy that has curative potential by halting MS progression and regenerating demyelinated tissue. My group has discovered a novel peptide with neurotrophic properties and which, in contrast to classical NTFs, (i) has neurorestorative effects and can enhance remyelination (ii) penetrates the blood-brain barrier (BBB), (iii) can be subcutaneously administered, and (iv) can be inexpensively produced. In REGENERA MS, we will evaluate the pharmacokinetic properties and efficacy of a novel therapeutic peptide in organotypic brain cultures, human induced oligodendrocyte-like pluripotent stem cell-derived cells and in MS animal models. Subsequently, we will verify the IP position and strategy, perform an in-depth market and competitor analysis, and finally consolidate these findings into a business case to establish the best path to commercialization.
Applying New solutions for Cultural Heritage protection by Innovative, Scientific, social and economic Engagement (ANCHISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Portugal,France,Greece,Germany,Italy,Belgium,Cyprus
Call: Protection of artefacts and cultural goods from anthropogenic threats (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 4037258.75
EU funding (EUR): 4037258.75
Participants: 15
Project status: SIGNED

ANCHISE - ‘Applying New solutions for Cultural Heritage protection by Innovative, Scientific, social and economic Engagement’ aims at offering to European societies efficient methods, knowledge and toolkit to enhance the protection of cultural heritage against looting and illicit trafficking. Crossing the methodology of networking that has proved its efficiency in the H2020 NETCHER project with the innovative results of new technologies developments (3D/photogrammetry for site monitoring, data engineering and AI for border control object identification and heritage collection protection, spectral fluorescence signature for object authentication), ANCHISE will create an operational set of tools applicable for European contexts and replicable in other situations abroad. The aim of the project is to bring coordinated solutions to the key existing needs in the domain of Cultural heritage protection: 1) Understand, 2) Prevent, 3) Act, 4) Repair. ANCHISE will consist of: 1) a hub of social science, politics and economics (for in-depth results likely to lead to structural evolutions in heritage protection), 2) a large-scale evaluation of technologies and needs, 3) a toolkit of innovative solutions, 4) pilot experimentation areas (museums, border control, archaeological sites), and 5) a unique and wide network of practitioners. 9 demonstrations will involve at list 150 practitioners. Guidelines and procedures on the use of ANCHISES tools will be largely disseminated (INTERPOL, PANDORA, institutions in charge of cultural heritage). The Consortium is a strong partnership of leading stakeholders in the fight against illicit trafficking of cultural objects: companies (PARCS, ICONEM, INOV), research centres (FRAUNHOFER, ICCS, Cyprus Institute), universities (French School at Athens, University Lyon 2, University of Poitiers, EUI Florence, Cyprus University of Technology), practitioners (France’s National Police College, ICOM), and associations (Michael Culture).

Keywords: 3d photogrammetry,archaeological site monitoring,data engineering,ai,border control,heritage collection protection,spectral fluorescence signature,object authentication,humanities,
Heterostructure Nano-photoelectronic Biosensor for Single Molecule Detection (hNanoBio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Finland,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 4
Project status: SIGNED

The key research goal of the project hNanoBio is to enhance the leadership and research capability of the Marie Curie Fellow, via implementing a highly challenging and innovative research project focused on the development of ultrasensitive heterojunction transistors by exploring heterostructure 2D materials and novel photoelectronic transistors for single molecule detection and clinical applications with whole blood in hospital settings. Pancreatic cancer, one of the deadliest aggressive solid tumours, is the third-leading cause of cancer-related mortality around the world. Earlier diagnosis can enable more effective surgery and subsequently improved survival. However, current diagnostic approaches are laborious, costly, time-consuming and difficult to identify small lesions. There is an urgent need for rapid, highly sensitive, and reliable approaches to overcome those drawbacks. Nanomaterials have attracted enormous attention due to their unique mechanical, optoelectronic and chemical properties. In particular, 2D materials have been recently explored as a new platform for building the next-generation biosensors. This project will exploit new emerging opportunities with the integration of photoelectronic technologies and heterostructure 2D materials to develop highly sensitive, rapid and promising performance biosensors for early diagnosis of pancreatic cancer. The Fellow will be trained in the fast growing nano-photonics science, technology and bio-application area at the host - Nottingham Trent University, UK, with further three well-designed interdisciplinary and inter-sectoral secondments in academic/industry/hospital scenarios.

Keywords: transistors,biosensors,heterostructure 2d materials
Endoplasmic reticulum remodelling via ER-phagy pathways (ER-REMODEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2496691.25
EU funding (EUR): 2496691.0
Participants: 1
Project status: SIGNED

The endoplasmic reticulum (ER) is the most extensive endomembrane system of the cell that undergoes continuous remodelling and adaptation to fulfil required functions in synthesis and transport of cellular components. A major driver of ER remodelling is ER-phagy, a selective autophagy pathway that targets excess or damaged portions of ER for degradation. By linking the ER membrane to the autophagic machinery, ER-phagy receptors play central roles in this process. However, beyond the identities of ER-phage receptors, we have little understanding of the mechanisms underlying ER-phagy and the dynamics of ER remodelling. This proposal aims to decipher the mechanisms by which ER-phagy receptors, especially those containing reticulon-homology domains (RHD), drive the dynamic process of ER remodelling in a cell-type specific fashion. We will determine how ER-phagy is regulated by site-specific receptor ubiquitination and by the formation of ER-phagy receptor clusters, particularly how ubiquitination regulates cluster size, dynamics, localization, identity and composition. We will combine structural, computational and functional approaches to determine, at the highest possible resolution, how ubiquitination and clustering of ER-phagy receptors controls the multistep process of ER-phagy and membrane remodelling. We aim for a comprehensive understanding of the distinct mechanisms involved in ER remodelling in different cell types and in response to various stress conditions. This mechanistic knowledge is essential to explain how changes in ER-phagy and ER remodelling impact on the pathophysiology of human diseases from bacterial infections to neurological disorders. These novel and ground-breaking discoveries will elucidate an ER-phagy receptor code controlling ER remodelling in health and disease. Moreover, ER-REMODEL will provide a conceptual framework for future studies into the dynamic regulation of other cellular organelles via ubiquitin-driven selective autophagy.

Keywords: er phagy,er remodelling,er stress,cellular homeostasis,reticulons,reticulon homology domain,ubiquitination,membrane dynamics,autophagy,neurodegeneration,legionella,molecular simulations,disease modelling,qproteomics,cell biology,post translational modifications,structural biology,receptor clustering
Platform for Helping small and medium farmers to Incorporate digital Technology for equal Opportunities (PHITO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Netherlands,Italy,Romania,Portugal,Spain,Hungary,Aruba,Bonaire, Sint Eustatius and Saba,Albania,Germany
Call: Smart solutions for the use of digital technologies for small- and medium-sized, farms and farm structures (HORIZON-CL6-2022-FARM2FORK-02-two-stage, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 5025142.5
EU funding (EUR): 4542116.25
Participants: 20
Project status: SIGNED

PHITO (Platform for Helping small and medium farmers to Incorporate digital Technology for equal Opportunities) introduces a ground-breaking digital tool specifically for small and medium farmers (SMFs) that are currently unable to benefit from the digital innovation increasingly adopted by larger producers. The platform connects data and people through a low-barrier app with two main purposes: (1) offering free data-driven farm advice on soil, water and crops tailored to SMFs (global element), and (2) improving synergic collaboration between farmers, consumers, and service providers while strengthening the local Agriculture Knowledge and Innovation Systems (AKIS ) (local element). PHITO distinguishes itself from previous initiatives as a key example of frugal innovation , by downscaling the complexity of digital farming and making smart use of existing open geo-databases (through public domain data harvesting), and embedding this in the various local food systems and networks. Through co-creation together with SMFs and numerous local farmer representatives, PHITO will help to bridge the digital divide by providing better access to information and local networking, helping SMFs to improve their decision-making processes and consequently their economic and environmental performances.

Keywords: frugal innovation global geodata farm advisory services sustainable land management