Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breaking down arenavirus cell entry (BRACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Hemorrhagic fever viruses are serious human threats for which we don’t have adequate treatments available, which is painfully highlighted by the current Ebola virus outbreak in Western Africa. These viruses are obligatory intracellular parasites that make use of the host machinery at every phase of their infection cycle. Virus attachment and entry are the initial steps, which requires engagement of a viral glycoprotein with a cell surface receptor. This interaction then triggers internalization of the virus particle via a Trojan horse-like vesicular pathway, eventually resulting in the release of the viral genome into the cytoplasm of the target cell. We have recently shown that cell entry of at least some hemorrhagic fever viruses (i.e. Ebola virus and Lassa virus) is even more sophisticated, as it requires triggered-recognition of an intracellular receptor as an unexpected additional step. A precise understanding of how these major pathogens enter cells is required to reveal the mechanisms by which they cause disease. In this application, I will combine targeted engineering of viral systems with a genomics approach that enables crystal-clear, yeast-like genetics in human cells. Focusing on arenaviruses, these genome-wide surveys will reveal host factors indicative of virus entry tactics never observed before. I will use biochemistry, microscopy, and cell biological assays to examine in detail the virus-host interplay with these factors and will identify promising new antiviral targets for arenavirus family members that cause human disease. Overall, I foresee that this project will provide a much-needed window on the unique cell entry strategies of these lethal pathogens, which thus far revealed a surprising diversity in the biological host networks being hijacked to establish infection.

Keywords: arenavirus,haploid genetics,cell entry,protein receptors
Exploring the circular bioeconomy potential in cities. Proactive instruments for implementation by policy makers and stakeholders (BIOCIRCULARCITIES)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Italy,Estonia,Belgium,Bulgaria,Luxembourg
Call: Expand circular economy to include the underexploited circular bioeconomy (H2020-BBI-JTI-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 999893.75
EU funding (EUR): 999893.75
Participants: 8
Project status: SIGNED

BIOCIRCULARCITIES aims at supporting the development of innovative and comprehensive regulatory frameworks and roadmaps aligned with circular bioeconomy principles, centred on ‘bio-based waste’ and based on feedback from multi-actor participatory processes. The project has been designed to i) explore the circular economy potential of unexploited bio-based waste streams generated in 3 European urban contexts around the cities of Barcelona (ES), Naples (IT) and Pazardzhik (BG); ii) identify and analyse circular bioeconomy best practices across the EU that could be used as successful example to use in the pilot areas; iii) detect regulatory and business opportunities and shortcomings for the introduction of bio-based processes and products into local and international markets, and iv) propose proactive instruments and policy roadmaps for supporting the circular bioeconomy and expand it to the European context. The strength of the project lies in the capability to bring together multiple actors belonging to the quadruple helix (businesses, research institutions, public authorities and civil society) to build the collaborative knowledge needed to map the different perspectives about legal and market limits/potentials for developing circular bioeconomy. Having a holistic picture of the legal and market opportunities and barriers in the 3 case study areas will make it possible to check the applicability of the identified best practices and other feasible solutions. The fiscal and economic impact due to the introduction of specific regulations will be considered to foresee the investments needed to support industry in making changes towards a more circular use of bioresources. Results obtained at local level will be a source of contents to develop generic guidelines to be exploited and further developed through communication, dissemination and exploitation actions at local and international levels.

Keywords: biowaste,cities,bio based,bioresources,multi actors,biocircular,life cycle thinking
Training towards a society of data-savvy information professionals to enable open leadership innovation (MOVING)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Austria,Slovenia,Poland,Greece,United Kingdom
Call: Innovative schemes for open innovation and science 2.0 (H2020-INSO-2015, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 3470253.75
EU funding (EUR): 3470253.75
Participants: 9
Project status: CLOSED

MOVING is an innovative training platform that enables users from all societal sectors to fundamentally improve their information literacy by training how to use, choose, reflect and evaluate data mining methods in connection with their daily research tasks and to become data-savvy information professionals. The platform provides users with technical support as well as social advice and learning input to organise, filter and exploit information in a more efficient and sustainable way. Thus, we tackle the core challenge of knowledge society to manage large amounts of information in a professional way. The ability for understanding, using and developing data mining strategies will become a basic cultural technique. In fact, information management is one of the basic competences today. The open innovation training platform MOVING is both: a working environment for the quality analysis of large data collections with data mining methods and a training environment with information, learning and exchange offers for digital information management. This connection of technical application and curriculum does overcome any artificial distinction in training and practice. The MOVING platform provides beyond state-of-the-art semantic search and analysis of large data sets. It makes its own functioning understandable to the users and offers individually configurable training programmes and guidance based on a proved qualification concept. The MOVING platform will be implemented in two use cases: (i) EY provides the use case of compliance officers with worldwide 60.000 public administrators. (ii) TUD provides a use case on educating young researchers on how to apply and interpret data-intensive research tasks. Here, we address 100.000 students. The exploitation is two-fold, a business-plan strategy for EY and a public-financed and tailoring of services-based strategy for the researcher use case. This will have decisive impact on the innovative capacity of the European society.

Keywords: training platform,data savvy information professionals,educating young researchers
Hybrid fuel-electric multicopter RPAS with 10 times more flight time than current solutions in the market (HYBRiX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2020-12-31
Duration (months): 30.0
Total project cost (EUR): 2142857.5
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Quaternium, current SME Instrument Champion at Phase 1, will create a new global market of long-endurance multirotor drones with over 2,000 Million € value, which the company will lead with 25% market share. This milestone will be achieved thanks to HYBRiX innovation, the first hybrid fuel-electric multirotor drone. HYBRiX has 10 times more flight time than its existing alternatives. This disruptive innovation will provide an highly valuable solution for customers who cannot afford a manned helicopter, but need more flight time than current multirotor drones can offer. HYBRiX innovation is currently at TRL6. With this prototype, Quaternium set the World Record of Multirotor Endurance in December 2017, performing a flight of 4hr and 40 minutes and achieving a wide communication impact worldwide. The expected outcome at the end of this project will be to have HYBRiX multicopter at TRL9, ready for commercialization and production at wide scale with initial traction and product / market / regulation fit. By then Quaternium will have capacity to assemble, storage, distribute and sell >500 HYBRiX UAS / year with a commercial representation and technical support network in Europe and North America and positioning in the global market as a leading European manufacturer of professional drones.

Keywords: drones,uavs,rpas,emergency response,transport,industrial inspection
Recording the Borders: Sounding Displacement and Integration in Europe (RecBord)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: CLOSED

Working at the intersections of music and refugee studies, RecBord examines soundscapes of displacement. It asks how sound mediates relations between refugee and host communities: How do experiences of forced migration manifest in sound? How do these sounds both enable and constrain processes of integration? Research and training take place in two European cities. It centres on Oslo, a target destination in many migration journeys into Europe. And it compares this with Athens, an arrival city in many of these same journeys. Arrivals and destinations, displacements and integrations – all have a soundtrack. RecBord gives focus to sound cultures in movement and circulation, pushing forward research in the developing field of music and migration studies. RecBord argues that integration must be studied from the bottom up. It focusses on everyday lived experiences of displacement. It develops methods of doing anthropology in sound, using approaches of sensory ethnography and centring on the production of soundscape recordings made by research participants in the two case study cities. This is about understanding how refugees analyse and articulate their own experiences. And this in turn is about recognising the agency of those displaced. Through training in academic excellence, human rights advocacy, and media outreach, RecBord aims to reach a diversity of listening publics: voicing new perspectives on migration, and disrupting dominant narratives of displacement.

Keywords: anthropology in sound,sensory ethnography
EXposome Powered tools for healthy living in urbAN SEttings (EXPANSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Estonia,Italy,Germany,Spain,Greece,Poland,Sweden,Switzerland,Poland,France,France,Czechia,Netherlands,United States,Netherlands,Netherlands,Netherlands,United Kingdom
Call: The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 11993907.03
EU funding (EUR): 11993906.99
Participants: 21
Project status: SIGNED

By 2030 more than 80% of Europe’s population will live and interact with a complex urban environment, consisting of a mixture of social and environmental factors. These factors include: where we live and work, where and what we eat, our social network, and what chemical substances we are exposed to. Individually or collectively these factors, known as the Urban Exposome, have an often modifiable impact on our health and provide important targets to improve population health. By studying the impact of the Urban Exposome on the major contributors to Europe’s burden of disease: Cardio-Metabolic and Pulmonary Disease, EXPANSE will address one of the most pertinent questions for urban planners, policy makers, and European citizens: “How to maximize one’s health in a modern urban environment?”. EXPANSE will take the next step in Exposome research by: 1) bringing together the Exposome and health data of more than 55 million Europeans in administrative cohorts, in-depth Exposome, phenotype, and OMICs information for more than 2 million Europeans, and personalized Exposome assessment for 5,000 individuals living in five “Urban Labs”; 2) applying a novel approach to use ultra-high-resolution mass-spectrometry to agnostically screen for exogenous chemicals in 10,000 blood samples; 3) studying the evolution of the Exposome and health through the life-course via both (matured) birth and adult cohorts; and 4) evaluating the impact of changes in the Urban Exposome on the burden of Cardio-Metabolic and Pulmonary Disease. EXPANSE will translate its insights and innovations into research and dissemination tools that will be openly accessible via the EXPANSE toolbox. By applying innovative ethics-by-design throughout the project, the social and ethical acceptability of these tools will be safeguarded. Tool discoverability and accessibility will be stimulated through the EXPANSE hub in which citizens, public sector policy makers, and private sector companies collectively participate. EXPANSE is part of the European Human Exposome Network comprised of 9 projects selected from this same call

Keywords: urban exposome,cardiometabolomic and pulmonary health,metabolomics
Single-Use unit and Process Analytical Infrared Spectroscopy (SUPAIR Spectroscopy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 1880327.5
EU funding (EUR): 1316229.25
Participants: 1
Project status: CLOSED

Biopharmaceuticals are medical drugs typically produced by mammalian cells in so-called bioreactors. It takes on average 10-15 years to bring a new drug to the market. Biomanufacturing costs can account for up to 30% of the overall costs needed to approve a new medicine. Currently, monitoring of bioproduction is mostly performed by using offline equipment that lacks robustness and has a reduced operational flexibility. Bioreactors are increasingly being monitored online and on real-time by means of Process Analytical Technologies (PAT). However, state-of-the-art techniques render both sub-optimal product quality and product efficiency. A few existing technologies based on Raman spectroscopy are highly expensive and probes are not robust enough, requiring consecutive sterilisation steps to be reused (raising water and energy consumption). At IRUBIS GmbH (spin-off of the Technical University of Munich), we have developed SUPAIR, a novel and robust ATR-MIR Sensor System aiming to make online and single-use monitoring of bioreactors by mid-infrared spectroscopy to become standard in the manufacturing of medical drugs. This approach will lead to increased operational flexibility, reduced costs of the manufacturing process, and will accelerate time-to-market of higher quality medicines to the patients. In the course of the Phase 1 project, we have validated our technical and commercial roadmaps through pilot testing with relevant biopharmaceutical players. Now we are getting closer to market, and we expect to conclude all technical developments and lay the ground for a successful market commercialisation by undertaking EIC Accelerator Pilot project.

Keywords: process analytical technologies,bioprocessing technologies,biomanufacturing,biopharmaceuticals,mid infrared spectroscopy,ftir atr spectroscopy,online monitoring of bioreactors
Sustainable Desalination System (SunAqua18)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 1891932.5
EU funding (EUR): 1324352.75
Participants: 1
Project status: CLOSED

Our Earth is drying-up. Water is an over-used vital resource worldwide and more than 1billion people still live in water-scarce regions and around 3,5 billion could experience water scarcity by 2025. Fortunately, 97% of all water contained on the Earth is in liquid phase & just few steps from the coast: Seawater. Within this scenario, global desalination capacity in 2015 reached 95 million m3 water per day, distributed among 18,700 plants worldwide. These incredible figures are translated into a global water desalination market already representing over €12 billion/year and CAGR of total cumulative contracted capacity over 9.5% per year. AQUA.abib S.L was founded in Barcelona (Spain) 2 years ago as a spin-off of BarcelonaTech after having completed the feasibility assessment of the invention. The introduction of SunAqua into the market will have a positive impact on: i) the economy of our customers, by allowing them to desalinate saline water at lower costs ii) the environment, and iii) AQUA.Abib’s economic growth. SunAqua18 consists of a pyramid-shaped structure with an octagonal base, measuring 18m in height (15m of column + 3m of human-beings), covering an area of 2.500m2. The structure is covered by an outer transparent plastic layer and an inner dark-coloured layer which is considered to efficiently harvest sunlight from sun. The system was validated by the end of 2013 with a SunAqua pilot-scale, which was running during 4 months. Moved by real market demand and several expressions of interest, we are committed to quickly moving towards our final commercial product, with overall dimensions assuring the best cost/efficiency ratio: SunAqua18. Thanks to the promising performance of the fully-operational prototype we estimate yearly revenues up to 19M€ by the end of the 5th year and cumulated benefits reaching 16.6€. These figures would allow us to assure a Payback period of our project lower than 3 years.

Keywords: desalination,small scale desalination,salt market,brine disposal,efficiency,eco innovation in arid areas,vapour compression,seawater spray drying
Pharmacological restoration of selective autophagy for the treatment of skeletal disorders (RE-STORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 162857.14
EU funding (EUR): 120000.0
Participants: 2
Project status: CLOSED

Lysosomal storage disorders (LSDs) are a family of inherited genetic diseases characterized by lysosomal dysfunction, with a consequent block in the degradative capacity of the cell. The skeleton is one of the most affected organs in LSD patients and current therapies are largely ineffective for the treatment of bone and cartilage manifestations. Thanks to the support of the ERC-starting grant BONEPHAGY we demonstrated that the degradation of the endoplasmic reticulum fragments via lysosome/autophagy pathway (ER-phagy) exerts ER quality control functions that are essential for secretion of procollagens. This process is impaired in LSD chondrocytes and osteoblasts, the cartilage and bone forming cells, respectively and accounts, at least in part, for the skeletal growth retardation observed in LSD mouse models. Prompted by these exciting findings, RE-STORE proposes to develop a novel cell-based integrated screening platform to identify selective ER-phagy inducers to target the skeletal phenotype of LSDs and contribute significantly to their development into innovative therapeutics. The access to proprietary library, through a collaboration with an industrial partner, and the set-up of a rapid hit confirmation in disease animal models will allow RE-STORE to establish a complete drug development pipeline for the selected hits. RE-STORE is an ambitious project that aims to develop an innovative substrate-to-lysosome screening approach for the study of selective autophagy and to identify new therapies for the so-called “ER-storage disorders” characterized by accumulation of misfolded polypeptides in the lumen of the ER.

Keywords: er phagy,selective autophagy,lysosome,small molecules,therapy,skeleton,lysosomal storage disorders