Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
International network for Leveraging sUccessful Cultural heritage Innovations and Diplomacy, cApacity building and awaREness raising (ILUCIDARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Cultural heritage
Action type: Coordination and support actions
Countries involved: Spain,Ecuador,Belgium,Belgium,Poland,Netherlands,United Kingdom,Kosovo
Call: International network to promote cultural heritage innovation and diplomacy (H2020-SC5-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-04-30
Duration (months): 41.0
Total project cost (EUR): 2869290.0
EU funding (EUR): 2869290.0
Participants: 9
Project status: CLOSED

ILUCIDARE is a three and a half year project to promote and leverage heritage-led innovation and international relations through the creation and activation of an international community of heritage practitioners in Europe and beyond, while strongly contributing to the overall objectives of the communication Towards an EU strategy for international cultural relations (JOIN/2016/029) and EU international cooperation in research and innovation (COM(2012)497). ILUCIDARE refers to both “elucidare”, aiming to provide a common definition of CH-led innovation and international relations, and “lucidare”, aiming to raise awareness, provide assistance, leverage and upscale CH-led innovation and international relations on a global scale. ILUCIDARE opts to tie its activities to strong established networks rather than just creating a new isolated project with little or no impact. The project will enable the exchanges of best practices, knowledge transfer, skills development and cross-fertilisation within its global network through an extensive use of digital engagement strategies and tools as well as participatory activities including focus groups and co-creation ateliers, 3 high-level international conferences – aka Playgrounds, 5 international competitions (including 4 ILUCIDARE special EU Prizes for Cultural Heritage / Europa Nostra awards), online training by means of a Youtube Learning Channel with community manager, 2 academic training courses, and onsite capacity buildings in 11 capacity buildings in 10 countries in Europe, the Western Balkans, South America, Middle East and Africa. The strong international component of ILUCIDARE activities will allow to foster intercultural dialogue and effectively improve EU external relations through cultural heritage diplomacy. Based on continuous exchanges facilitated by a special appointed Community Manager, ILUCIDARE will act as an hub for heritage-led innovative solutions and will support spill-overs and sustainable development collaborations to better preserve and promote heritage, especially where it is at risk.

Keywords: cultural heritage led diplomacy and innovation,international capacity building actions,knowledge transfer,co creation,community management,social media,pestle
An experimental approach to understand inDuced sEismicity in GAS Shales (DEGASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Natural gas recovered from shales is becoming an increasingly important energy source worldwide. The hydrofracturing technique used to obtain shale gas can cause unstable fault slip, giving rise to induced seismicity, but has recently been shown to also lead to stable, slow-slip fault behaviour. Successful, safe and publically accepted global implementation of shale gas recovery critically depends on understanding the conditions leading to the different types of fault slip. The principal objective of the proposed research is to determine the conditions and the microscale deformation mechanisms that lead to stable versus unstable fault slip of reactivated faults in clay- and quartz-rich gas shales. This objective will be achieved by a combination of experiments, microstructural analyses and microphysical modelling work, to be conducted primarily at the University of Liverpool (ULIV), UK, complemented by a secondment in the non-academic sector. This work builds upon my PhD and postdoctoral work that focussed on the slip-stability of similar clay-quartz materials, but from subduction zone megathrust settings. New techniques available at ULIV, together with the novel links with industry to be established in the research, will bring about a major advancement of my academic career. This fellowship will thus contribute to the achievement of the goals of the Horizon 2020 Work Programme. The main end-products of this study – the physical properties of gas shale, either measured or predicted with a microphysical model for gas shale deformation, can be implemented by shale gas companies to plan and monitor their hydrofracturing activities better. These results will also serve as a sound basis for public education. The outcomes of the study, i.e. a more fundamental understanding of, and microphysical basis for, phyllosilicate-quartz friction, will also be of importance for the broader community concerned with fault friction – notably subduction megathrust friction.

Keywords: shale gas,hydrofracturing,induced seismicity,physical properties,friction,slip stability,microstructure,deformation mechanisms,microphysical model
Developing new therapeutics for Friedreich ataxia (FAST-DEVELOPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Friedreich ataxia (FRDA) is a devastating neurodegenerative orphan disease that affects children and young adults, and has no approved therapy. The disease progressively brings patients to severe disability and significantly reduces life expectancy. The genetic defect underlying the disease causes FRDA patients to produce only low amounts of the mitochondrial protein frataxin, compared to normal subjects. Low frataxin results in the accelerated death of peripheral sensory neurons, causing the disease. Goal of any tentative specific therapy is therefore to increase frataxin levels in FRDA patients. Building on our original discovery that unveiled the mechanism of physiological frataxin degradation, we are developing new chemical entities that manage to increase frataxin in FRDA patients cells by preventing the degradation of frataxin. This effort is currently funded by an ERC Advanced Grant (Friedreich Ataxia Seeks Therapy – FAST, project number 293699). We now plan to bring some of the most promising compounds emerging from the above mentioned ERC-funded project, to the proof of concept (POC) of efficacy in living sensory neurons derived from FRDA patients. This will be achieved by demonstrating that our compounds are able to increase frataxin in sensory neurons generated from patient-derived induced pluripotent stem cells. A defined path for the further de-risking and development of compounds that have reached the POC stage, has been discussed together with Cydan Development, the leading orphan drug accelerator, and the VC firm Kurma Partners.

Keywords: friedreich ataxia,ubiquitin,frataxin,orphan drugs
Deciphering the metabolic roles of the urea-cycle pathway in carcinogenesis for improving diagnosis and therapy (UreaCa)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Almost 100 years ago, Warburg described a metabolic change in energy flux that occurs during carcinogenesis. Since then, multiple studies have demonstrated how anabolic synthesis of macromolecules can be altered to support cancer cell progression. Yet, the potential effect of altered catabolic degradation of macromolecules on tumour carcinogenesis has been much less studied. The urea cycle (UC) is the main catabolic pathway by which mammals excrete waste nitrogen. Although the complete UC pathway is liver-specific, most tissues express different combinations of UC enzymes according to the cellular needs. Surprisingly, we find that changes in expression of UC components causing UC dysregulation, (UCD) is a global phenomenon in cancer, metabolically augmenting net nitrogen usage for the synthesis of macromolecules by reducing nitrogen waste. This metabolic alteration is associated with poor patient prognosis. Thus, we hypothesise that UCD provides a major metabolic advantage to multiple aspects of carcinogenesis and as such, leads to specific, identifiable genomic and biochemical signatures, with implications for cancer diagnosis and therapy. To pursue our hypothesis, we will incorporate state-of-the-art comparative genomic, peptidomic, metabolomic, and molecular approaches to explore this scientific “blind spot” of nitrogen metabolism in carcinogenesis. We will investigate how UCD causally affects carcinogenesis, by characterising tumour-specific functions of UC enzymes (Aim I), correlating tumour phenotypes with systemic biomarkers (Aim II), and testing the treatment efficacy of drug combinations targeting UCD in cancers (Aim III). Our proposal, strengthened by my training as a physician scientist, harbours considerable potential for translational diagnostic and therapeutic utility of our findings, enabling us to i) identify new diagnostic biomarkers for monitoring cancer initiation and progression and ii) predict and enhance the therapeutic response.

Keywords: cancer metabolism,amino acid metabolism,bio markers,immunotherapy,mutagenesis
Quantitative detection of bacterial endotoxin by novel nanotechnological approaches (ENDONANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Spain,Italy,Italy,Hungary,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 1035724.38
EU funding (EUR): 1035724.38
Participants: 9
Project status: SIGNED

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of diagnostic detection assays and one biotech company specialised in (magnetic) microbead technology, and two Participant Organisations (SMEs). All have proven experience in higher education and training,

Keywords: quantitative evaluation of bacterial endotoxin contamination,health safety,decontamination,new detection methods,nanotechnology,innovative fluorescent detection systems,plasmonics
Versatility of scaffold complexes in vivo to control synaptic plasticity (VERTICAL CITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2021-05-31
Duration (months): 72.0
Total project cost (EUR): 1964199.0
EU funding (EUR): 1964199.0
Participants: 1
Project status: CLOSED

Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically relevant signaling pathway of a given receptor. We propose that in the brain, receptosome dynamics is involved in fine-tuning synaptic transmission and plasticity, which might be crucial for cognitive functions. First, we will establish the link between molecular events, neuronal signaling and memory performance. More than correlations, this project proposes live recording of molecular events and cellular signaling during memory encoding. Second, new specific therapeutic targets will be proposed for the treatment of cognitive deficiencies: instead of interfering with the ligand-biding pocket of the receptor, we propose to target specific scaffold interactions. This strategy will only modify a specific altered function of a receptor without modifying other functions (thus, avoiding undesired side effects). Third, within the scope of this proposal, we will develop innovative, powerful techniques that will be of high interest for a broad community of researchers in life sciences. These technologies will enable to monitor the versatility of protein-protein interactions in space and time ranging from in cellulo to in vivo BRET imaging in freely behaving animals. To conclude, we will establish the functional significance of oligomer remodeling in the physiological synaptic plasticity and try to restore it in neurological disorders.

Keywords: genomics,comparative genomics,functional genomics,psychiatric disorders
Next Generation IoT as part of Next Generation Internet (IoT-NGIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Italy,Spain,Italy,Cyprus,Finland,Greece,Greece,France,France,Luxembourg
Call: Next Generation Internet of Things (H2020-ICT-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 7998622.5
EU funding (EUR): 7998622.5
Participants: 25
Project status: SIGNED

Internet of Things (IoT) is one of the next big concepts to support societal changes and economic growth, being one of the fastest growing ICT segments. A specific challenge is to leverage existing technology strengths to develop solutions that sustain the European industry and values. To address this, IoT-NGIN introduces novel research and innovation concepts, to establish itself as the “IoT Engine” that will fuel the Next Generation of IoT as a part of the European Next Generation Internet. First, IoT-NGIN uncovers a patterns based meta-architecture that encompasses evolving, legacy, and future IoT architectures. Second, it optimizes IoT/M2M and 5G/MCM communications, including using secure-by-design micro-services to extend the edge cloud paradigm. Thirdly, it enables user and self-aware, autonomous IoT systems through privacy-preserving federated ML and ambient intelligence, with AR support for humans. Finally, IoT-NGIN researches towards distributed IoT cybersecurity and privacy, for example, using Self-Sovereign Identities and interconnected DLTs to implement Meta-Level Digital Twins. IoT-NGIN will be validated via more than 30 types of heterogeneous IoT devices, ranging from tiny resource constrained IoT sensors to intelligent, autonomous buses, drones and robots, deployed in one of the most prestigious IoT/5G lab (OneLab) and five Living Labs: the “Twin Cities” Living Lab in Helsinki/Tallinn, a fully customizable Smart Agri Living Lab in Greece, the BOSCH and the ABB employee-friendly Industry 4.0 facilities in Barcelona and Helsinki, and a hybrid field-lab facility focused on Smart Energy, interconnecting Terni City and EDD Eurolab in Aachen. Beyond partners exploitation plans, to maximize impact and sustainability, IoT-NGIN will push all results via alliances, clusters, SDOs and DIHs, including FIWARE, BDVA, and AIOTI, offer developed software as open source, and organize open Open Calls to engage FGPA/ASIC/fabless and IoT application developers.

Keywords: inter dlt technologies,living labs validation,machine cloud machine mcm,federated data sovereignty,deep,self ml,iot cybersecurity,human centred use cases
Advancing frontiers in personalised foods for seniors through nanotechnology and 3D printing aiming enhanced nutrition and superior flavor (3D-NANOFOOD)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2020-03-02
End date: 2023-09-12
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: TERMINATED

Ageing accelerates the prevalence of malnutrition due to physiological changes, such as masticatory and swallowing dysfunctions, body composition changes and special nutrition needs. In addition, degradation of sensory functions in seniors results in an appetite decrease. Therefore, personalised foods that enable optimal nutritional maintenance and food pleasantness are required, being a cornerstone for healthy ageing. The main goal of this research project is to provide innovative and feasible strategies to manufacture personalised foods for older adults with superior nutrition and sensory properties. This action proposes the combination of promising techniques including nanoencapsulation, food enrichment and 3D printing to manufacture personalised foods. 3D printing is a versatile and emerging technology that will enable fast food manufacturing and flexibility to formulate products with target texture and special nutrition needs. Food enrichment with functional compounds (e.g. flavourings and bioactive compounds) can improve the quality and functionality of printed foods. For instance, flavourings can reinforce the taste and smell of printed foods, making them more palatable; while fortification with bioactive compounds can promote health. However, the process of food fortification entails technological challenges, affecting the food attributes. This will be addressed using nanostructured delivery systems for protecting and/or enhancing the performance of functional compounds. The work plan of this project proposes: 1) the fabrication of nanoparticles and nanostructured layers using electrospraying and ultrasonic spray for delivering bioactive compounds and flavours; 2) the design of texture-modified foods using 3D printing containing nanoparticles or nanostructured layers loaded with functional compounds; 3) the evaluation of the quality and functionality of the new foods developed, and 4) the development of an industrial protocol for printed foods manufacturing.

Keywords: nanoencapsulation,bioactive compounds,flavourings,3d printing for food,healthy ageing,new food structures
Intelligent System for Pressure Networks (ISPNET)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Management and maintenance of pipe systems present a major problem: leaks. The existence of leaks is costly, both economic and environmental terms, especially when considering finite resources. The ISPNET project proposes a new smart pipe system for early detection of leaks and preventive maintenance of networks, including a last generation of transmission system specifically tested for water distribution, but with further application in other fluids’ transportation networks (oil & gas, industrial liquids…). The new system, which has been installed and subject to public trials, will optimize the properties of existing piping systems and in turn, serve as reporter element of all incidents occurring in the pipe system and as management tool of parameters commonly used. The solution offer innovative advantages both in terms of the materials used for the pipe and due to the monitoring and traceability possibilities of the embedded sensor system. There is no other similar system in the market, and the cost per meter of the system is lower than “conventional” ones. SME INSTRUMENT Phase 1 will help to define requirements to validate the product in different configurations (dimensions, monitoring functionalities) and uses (drinking water and other fluids), as well as to automate the production process. Through a feasibility study, ABN will measure the potential of the solution in terms of efficiency, business opportunity and compliance with standards, analyze the commercial impact of the device and define the market in concrete and realistic terms, in order to attract investors. All this will reduce time to market for a very promising solution, which has received expression of interest of major water distrubution companies. It has also been recently (April 2015) awarded at first Ideas Competition (Sustainability award) launched by the Spanish network of Smart and Innovative Cities RED INNPULSO.

Keywords: pipe systems,water distribution,pressure fluids,leaks,sensors,monitoring,resources management