Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Measuring all cells of Drosophila development to reconstruct differentiation trajectories and understand the language of the genome (4D Development)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

How the genome regulates the differentiation trajectories that instruct a single fertilised egg to develop into an adult organism is a longstanding question in biology. Here, high-throughput spatial transcriptomics will be leveraged to virtually measure all cellular states of the Drosophila melanogaster. The entire ten-day development of the fruit fly will be sampled with a four-hour interval, where the spatial gene expression of 1,600 genes will be measured in a serially sectioned fly at single cell resolution. The sections will subsequently be reconstructed into 3D models. This approach enables whole-body-biology where a complex measurement is taken of all cells of an entire individual and is here used to densely sample development. In order to reconstruct differentiation trajectories, the 3D fly models will be anatomically aligned between timepoints so that cellular states can be linked and transitions in transcriptional profiles can be studied. The spatial information will substantially simplify this challenge because progenitors and putative progeny will be in the same anatomical compartment. This will generate a 4D developmental model of the fruit fly that links cells, cell types, anatomy and differentiation in space and time. The 4D developmental fly and the cell type trajectories will serve as the manifold onto which single cell transcriptomics (RNA-seq) and chromatin accessibility (ATAC-seq) data will be integrated. Then, Gene Regulatory Network inference tools can be used to identify transcription factors and enhancer sequences that drive lineage decisions. Investigating the enhancer sequences will reveal how cell type specificity is encoded and how the arising complexity is regulated during development. This project will give a unique insight into development, patterning and the emergence of cellular diversity from the genome, and will form an important proof of concept to approach development in other larger organisms such as mice and humans.

Keywords: spatial transcriptomics,gene regulatory networks,drosophila melanogaster,smfish,merfish
Building blocks of human sociality: A comparative assessment of joint action in humans and their closest ape relatives (JORIGINS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Many social animals collaborate, but only humans supposedly engage in joint action – cooperative interactions that involve normative, mutually obligating joint commitments (JCs). This enabled the evolution of hyper-cooperation observed in human societies, including complex collaborations like governments, and has likely played a pivotal role in human evolution. Given the significance, there has been a long-standing interest in the ontogenetic and evolutionary origins of joint action capacities like JC. The classical approach employed experiments with human children and nonhuman great apes, showing that while humans engage in joint actions, apes’ interactions rely on egoistic motives. However, such tasks are highly anthropocentric, involving engagement with human confederates in human-centric tasks. Conversely, drawing on a more ecologically valid approach, my research demonstrates that when apes interact with conspecifics naturally, they appear to exhibit specific joint action capacities like JC. Yet firm conclusions cannot be drawn unless the following empirical issues are solved: i) behaviours do not permit insights into internal mechanisms, ii) comparative joint action research is still in its infancy, lacking a holistic picture of affective and behavioural processes supporting coordination, and iii) previous ape studies are deficient of critical experimental controls. Building on and expanding my unique expertise in this domain, this project overcomes these challenges by pioneering a comparative investigation of spontaneous joint action coordination in human children and bonobos. Using cutting-edge tracking and thermal imaging techniques, as well as timely controls, the project explores pivotal joint action signatures like communicative repair, bodily synchrony, and JC-related emotions. This offers a powerful assessment of the hypothesis that humans and apes share basic joint action capacities, highlighting the evolutionary building blocks of human sociality.

Keywords: joint action,great apes,affective states,tracking techniques,thermal imaging,collaboration,communication,emotion,joint commitment
COMMERCIALIZATION OF AERIAL TOOLS APS (CAT) (AT)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Denmark
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Aerial Tools ApS (AT) is a Copenhagen based deep tech start-up. AT develops its own hardware and software intellectual property (IP) to produce a revolutionary Unmanned Aerial System (UAS) capable of unique inspection methodologies for remote and large infrastructure, with initial focus on maintenance inspection of solar parks. The aim is to improve aerial data acquisition in B2B commercial inspections and monitoring. During this project, we target to accelerate commercialization, boost our product and business development and attract private funding. We expect to achieve product market fit and validation of our inspection specification by performing pilot projects with potential customer. Finally, we expect to expand our team by attracting sales experts and automation engineers. One of our scope troughs the Women TechEU program is to attract and inspire other women to follow our passion into deep tech by getting in touch with women role models. We would like also to better understand gender equality policies and how to apply them within our organizations to promote women within a safe space that enable further possibilities for them. With the Women Leadership Programme (WLP), we expect to learn from experts in the same environment with similar challenges. Mentoring and coaching is something that we really value to improve our business plan, define the company strategy and reach commercialization before the end of the program. In addition, we are currently looking for investment.

Keywords: drone,renewable energy sector,inspection,monitoring,agriculture,lidar
Actions for Climate Transition by developing Future Aquaculture Strategies and Technologies (ActFast)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Italy,France,Malta,Norway,Spain,Greece,Egypt,Hungary,Slovenia,Tunisia,Croatia,Austria,Poland
Call: Minimising climate impact on aquaculture: mitigation and adaptation solutions for future climate regimes (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 5060047.5
EU funding (EUR): 4497394.07
Participants: 32
Project status: SIGNED

ActFast aims to identify, validate, and demonstrate climate change adaptation and mitigation solutions tailored for European aquaculture, alongside opportunities to increase sustainable production. Targeting regions where aquaculture is deeply integrated into the socio-economic fabric, the project will map climate hazards across the Mediterranean Sea, Deltas, Central-Eastern European inland waters, and North-East Atlantic Ocean, utilizing historical data, predictions, stakeholder insights, and satellite surveys. Integrating this comprehensive data analysis, the project will develop a user-friendly early warning system for the Mediterranean region empowering aquafarmers to proactively manage and mitigate climate risks. ActFast will promote the development of fast and replicable climate solutions for marine, transitional, and freshwater aquaculture by integrating climate prediction models with targeted solutions in four target regions. Given the unique impacts and sensitivities of the targeted areas and aquaculture systems, ActFast aims to design mitigation strategies that consider both regional and species-specific characteristics, boosting the productive efficiency, health, and well-being of farmed fish and mollusks struggling against climate change's impacts, increasing and diversifying production in coastal and rural areas, promoting economic growth and community resilience, and minimizing environmental impact and shrinking European aquaculture's carbon footprint. The proposed innovations will be shared through an inclusive dissemination and communication plan, while the market uptake of the results and outputs will be ensured by a detailed exploitation strategy. To achieve maximum exploitation, dissemination, and knowledge transfer, ActFast will develop and implement a "Virtual ActFast Lighthouse", an immersive demo-training virtual reality collecting data from diverse experiments and field operations conducted across multiple work packages.

Keywords: climate change
Leading in the brave new world: human - robot dynamics (HURO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Lithuania,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 176773.44
EU funding (EUR): 176773.44
Participants: 2
Project status: SIGNED

Leading diverse human-robot or human-AI teams is slowly becoming the new normal. As automation and AI become integral to many industries, leaders must learn how to manage teams that include humans and AI/robots. Although there is plenty of training on how to use the technology, however, no one is teaching leaders how to lead the technology, thus creating skills gaps and workforce adaptability issues. As organisations face digital disruption, leaders must integrate these digital innovations into their operations and inspire their teams to become ‘technologically savvy’. However, despite the pressing need to better understand how to cultivate cohesive team dynamics amidst human and AI entities, research in this field is limited, which is problematic as leaders lack evidence-based solutions to deal with these novel challenges. Therefore, this project aims to unlock the potential of human-AI collaboration by: 1) uncovering the essential leadership qualities needed to effectively lead human-AI teams; 2) optimizing the design of virtual teams, where humans and AI work symbiotically; 3) pioneering the use of the newest AI for accurately assessing individual traits through natural language analysis; 4) investigating how feedback acceptance varies when it comes from human or AI sources. This research integrates the scientific fields of leadership, organisational psychology and IT, which pushes the boundaries of traditional research domains. Moreover, it is built on the newest technological trends and employs cutting-edge deep neural network technologies offering a state-of-the-art exploration of the subject. All in all, by achieving these objectives, this project will reshape the future of work, empowering organizations to harness the full potential of human/AI teams, enhance leadership capabilities, and optimize team dynamics in this ‘brave new world’ of workplace digitalisation.
Regions4Climate (R4C)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Finland,Denmark,Germany,Greece,Italy,Portugal,Spain,Estonia,France,Cyprus,Belgium,Bulgaria
Call: Large scale demonstrators of climate resilience creating cross-border value (HORIZON-MISS-2021-CLIMA-02, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 26602703.13
EU funding (EUR): 24522103.0
Participants: 47
Project status: SIGNED

Increasingly frequent extreme weather conditions due to climate change concomitant with unsustainable historical resource use and management practices create the perfect storm - threatening our livelihoods, well-being and environment. A transition towards resilience requires that we simultaneously address social inequalities and implement cross-sectoral innovations to build social, economic and environmental resilience to extreme events. Together, Regions4Climate partners commit to addressing current and forecasted climate change-related challenges and building more resilient European communities within an innovative socially engaged, citizen-driven paradigm. We aim to develop smarter, more inclusive, more resilient regional ecosystems through cross-sectoral innovation jointly created with stakeholders, by and for people. The development and implementation of cross-sectoral strategies that incorporate combinations of social, technological, digital, business, governance and environmental solutions to common climate resilience challenges is at present constrained by knowledge deficits and uncertainties, as well as science-policy-stakeholder gaps. Regions4Climate will bridge these gaps and address existing uncertainties by further developing, adapting and integrating state-of-the-art technical know-how, innovative tools and collaborative practices to support transparent, evidence-based risk and vulnerability analyses and robust decision-making processes. We will utilise system dynamic modelling to understand relationships among and trade-offs between different resilience innovations, providing tools for informed decision-making tailored to engage stakeholders and support European regions and communities exposed to significant climate change impacts. New scientific insights, along with a framework of interoperable tools, methodologies and demonstrated solutions will enable European regions to develop their own resilience plans and transformative adaptation pathways.
UTOPIZE - Urban Transformation Through Open Participation And Inclusivity For Citizen Empowerment (UTOPIZE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Innovation actions
Countries involved: Portugal,Italy,Sweden,Finland,Austria,Belgium,Poland,Denmark
Call: New governance models for the co-design and co-construction of public spaces in neighbourhoods by communities (HORIZON-MISS-2024-NEB-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 4161066.25
EU funding (EUR): 3944822.5
Participants: 13
Project status: SIGNED

The UTOPIZE project is a response to the pressing urban, ecological, and social challenges reshaping Europe, driven by climate change, social exclusion, energy poverty, aging populations, and other complex issues. Aligned with the New European Bauhaus (NEB) principles of sustainability, inclusivity, and aesthetics, UTOPIZE proposes a participatory framework that involves communities in the co-design and governance of public spaces across urban, peri-urban, and rural environments. The project is structured around the concept of UTOPIA, not as a static ideal but as an evolving process of community engagement. Through UTOPIA Labs, citizens co-create and transform their neighbourhoods, utilizing digital tools like Extended Reality (XR) and Geographic Information Systems (GIS) to enhance real-time urban planning and decision-making. These labs foster inclusivity by involving marginalized communities such as ethnic minorities, low-income populations, people with disabilities, and others at risk of exclusion. UTOPIZE's approach is deeply participatory, involving communities at every stage from local activation events to co-design workshops. The project operates across three demonstrator countries—Portugal, Italy, and Sweden—before expanding to six additional countries through a Twinning Program, ensuring scalability and adaptability. UTOPIZE aims to create resilient, sustainable, and culturally relevant public spaces that strengthen social cohesion and reflect the local identity and history of each neighbourhood. The project also integrates Nature-Based Solutions (NBS) and sustainable materials into the design and transformation of public spaces, contributing to environmental resilience and climate neutrality goals. By bringing together experts from multiple disciplines—architecture, engineering, social sciences, and the arts—UTOPIZE ensures a holistic and transdisciplinary approach to urban transformation. UTOPIZE’s comprehensive monitoring and evaluation framework.

Keywords: urban transformation,sustainability,inclusivity,co creation,participatory governance,new european bauhaus,digital tools xr,gis,social cohesion
Enhancing entrepreneurial ecosystems for education (ENTREPRENEDU)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Italy,Germany,Belgium,Greece,Bulgaria,Ireland
Call: Expanding Entrepreneurial Ecosystems (HORIZON-EIE-2022-SCALEUP-01, 2022)
Start date: 2023-01-15
End date: 2025-07-14
Duration (months): 30.0
Total project cost (EUR): 1173227.18
EU funding (EUR): 1048950.03
Participants: 8
Project status: CLOSED

ENTREPRENEDU brings together different innovation stakeholders and educational entities from 6 different European countries, 3 low/moderate innovative regions (IT, BG, EL) and 3 high innovative regions (BE, DE, IE). The project aims at creating a high replicable and scalable education model (c.d. Venture Capital Program) for both businesses and educational systems via a series of 3 Hackathons, developed at regional level, supporting developed concept and ideas to become concrete solution. At the end of the project, the program will be validated in the 3 educational entities that are part of the consortium. More specifically, ENTREPRENEDU aims at: • Enhancing the proliferation of new business model and entrepreneurial skills, directly involving 90 teams of youth (age 18 to 30 years old), in 3 different Hackathons (30 teams per Hackathons) ; • Providing a highly-replicable model to provide business know how for young Europeans, which will be validated in 3 educational institutions (IT, GR, BG) ; • Supporting the 12 most viable and promising ideas and concepts from the early stages to the commercialization of their solutions, through 5 concrete outcomes that should be reached by the end of the project (please refer to section 1.3) ; • Validating the Venture Capital Program (educational model) in 2 Universities and 1 VET entity on 90 students. The ENTREPRENEDU unique and interdisciplinary methodology will enhance entrepreneurial know-how and business skills and activities in less and moderate developed innovation regions, thus reinforcing their acceleration capacity and enabling youth to scale their concept to fully concrete solutions with strong market potential, subsequently enhancing the development and competitiveness of these regions.

Keywords: venture capital program for youth hackathons cross fertilization
NATURAL INTRAOCULAR PHOTOACTIVATION OF COMPOUNDS TO FIGHT RETINOPATHIES (NeoVasculoStop)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland,Hungary,Czechia,Lithuania
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 2988434.75
EU funding (EUR): 2988434.75
Participants: 6
Project status: SIGNED

Retinopathies constitute an extreme societal and socioeconomic burden that is expected to increase with an aging population and the increased prevalence of diabetes. These diseases, including age-related macular degeneration and proliferative diabetic retinopathy share neovascularization as a common etiology involving the pathological growth of retinal capillaries leading to blindness if left untreated. Current treatment modalities involve specialized injections into the eye that require not only outpatient visits to specialized treatment centers but are also associated with significant adverse effects. Orally bioavailable medications could revolutionize the treatment of retinopathies, by reducing adverse effects, sustaining vision, lowering the direct and indirect financial burden associated with these diseases, and increasing access to healthcare. Inspired by this idea, we have developed an approach that can be exploited to target essentially any therapeutic molecule to the eye. Our novel strategy of drug targeting will not only enrich the modified molecules in retinal tissue but will also reduce the therapeutic oral dose compared to existing anti-angiogenic therapy in cancer thereby increasing the safety of the treatment. This is achieved by absorbing a minute amount of the chemically and biologically stable molecules resulting in an extremely low plasma concentration and relying on a biological mechanism in the eye to activate the molecules to tether them to retinal target receptors and thereby extracting them from the blood. In the present application, we propose to demonstrate proof-of-concept of this strategy by modifying inhibitors of the vascular endothelial growth factor receptor (VEGFR). VEGFR is an endothelial receptor tyrosine kinase that is a key mediator of angiogenesis and an established drug target for the treatment of retinopathies. Our approach will elicit a paradigm shift in how we design future drug delivery strategies to the retina.

Keywords: oral drug,chemical modification,vegfr,retinopathy,neovascularization