Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Intestine-on-a-chip for investigating microbioal-epithelail interaction (iChip)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2021-02-12
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The small intestine forms a barrier that protects us against the outer world. Here commensal bacteria are tolerated while pathogens are effectively fought off. Occasionally, however, pathogenic bacteria colonize the intestine causing different diseases, which constitute a huge burden worldwide. The ability to study interactions of pathogenic bacteria with the intestine will provide new insights into the disease mechanisms, and new therapeutic targets and ways to prevent disease occurrence. Current animal and 2D models based on tumor cell lines both have shortcomings as they react differently to pathogenic bacteria when compared to healthy human tissues. Primary intestinal epithelial cells can now be cultured as intestinal mini-guts, 3D mini organs. This has partly overcome some of these shortcomings with mouse models and tumor cell lines. These mini-guts are, however, challenged topologically as the intestinal lumen is facing towards the inside of the structures. This makes it difficult to access the luminal surface and study microbial interactions with the epithelium. Furthermore, the static culture conditions do not mimic the in vivo conditions closely enough. I will use microfluidics and microengineering to develop an intestine-on-a-chip device based on primary human intestinal epithelial cells expanded as mini-guts but assayed on mimics of the natural villi structures found in the small intestine. Additionally, the model will allow the fluidic (sheer stress) and mechanic (peristalsis) microenvironment to be closely controlled in order to generate in vivo-like conditions. This is important to study as e.g. Crohn’s disease, that induces suppressed peristalsis, is associated with intestinal inflammation and bacterial overgrowth. Altogether, this intestine-on-a-chip device will go beyond state-of-the-art and for the first time give causality to the number of correlative studies reporting on how commensal and pathogenic gut bacteria affect the human physiology.

Keywords: microfluidics,organ on a chip,intestinal stem cells
An innovative bio-based platform for the cost-competitive production of L-fucose, a building block for Human Milk Oligosaccharides (HMOs). (FucoPol)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Portugal
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2020-09-30
Duration (months): 36.0
Total project cost (EUR): 1881707.5
EU funding (EUR): 1317195.25
Participants: 1
Project status: CLOSED

73100 have developed and patented a novel bacterial fermented biopolymer – FucoPol – as a natural source for the efficient production of pure L-fucose. L-fucose is a rare monosaccharide with limited natural availability and a precursor of complex carbohydrates, as Human Milk Oligosaccharides (HMOs). HMOs, which are highly abundant in human milk but not in infant formula, have been recently recognised as natural molecules with high potential for nutritional and biomedical applications. Despite the increasing market demand of these “specialty carbohydrates”, large scale production of HMOs is currently not feasible. Current technologies are hindered by the complexity and costs related to the attempt to increase the availability of the core component L-fucose. In fact, this monosaccharide acts as building block for HMOs, representing over 60-70% of the oligosaccharides portion in human milk. FucoPol – as natural source of pure monosaccharides - solves the main industrial issues related to L-fucose production such as the complexity, costs and efficiency. FucoPol bio-based platform offers a sustainable solution for industrial-commercialization of HMOs, by significantly increasing L-fucose availability. Completing the innovation project objectives will result in the validation of the platform and enable the production of large amount of high-pure L-fucose to meet the quality/quantity industrial demand for this rare sugar.

Keywords: monosaccharides,rare sugars,human milk oligosaccharides,bioproduction,infant nutrition,prebiotics,fermentation,carbohydrates,biopolymer,bio products,food
Mechanisms of neuronal network remodeling in the adult mammalian brain (NeuroRemod)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-12-31
Duration (months): 69.0
Total project cost (EUR): 1493750.0
EU funding (EUR): 1493750.0
Participants: 2
Project status: SIGNED

Traumatic events such as strokes or lesions to the adult brain can trigger large-scale reorganization of neuronal activity thought to be critical for functional recovery. The anatomical and molecular events underlying such reorganization remain an enigma. While rapid and short term changes of connections at the synaptic scale are widely studied, little is known about the principles and mechanisms of long-term and large-scale reorganization of axonal branches in mature circuits. I hypothesize that long-range axonal branching events in a minority of neurons contribute significantly to the plasticity and reorganization of adult neuronal circuits via unknown intrinsic mechanisms of axons survival and extrinsic environmental cues. A major reason why so little is known about axon dynamics in the adult brain has been the immense technical challenge of imaging rare axonal events in the dense meshwork of the adult brain. To solve this problem, I will apply new 3D imaging and genetic tools I developed to help visualize and quantify axons and synapses in the whole brain in an unbiased way. First, I will study the brain-wide neurite and synaptic dynamics after lesion and their effect on circuit function and homeostasis to shed light on the scale of brain plasticity. Second, I will characterize the intrinsic molecular pathways controlling activity-driven branch dynamics with viral approaches. I will make extensive use of tissue clearing, 3D imaging, and state-of-the-art image analysis pipelines to streamline the analysis of neuronal network properties. Third, I will investigate the extrinsic molecular and environmental factors promoting axonal dynamics in the context of adult brain structural plasticity. By generating a conceptual and mechanistic framework for the properties and mechanisms of injury induced brain reorganization, this study may contribute to the future design of new strategies to promote brain repair and curb the progress of neurodegenerative diseases.
Copenhagen Airport: a Lighthouse for the introduction of sustainable aviation solutions for the future (ALIGHT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Innovation actions
Countries involved: Germany,Italy,Spain,Italy,Germany,Switzerland,Lithuania,Poland,Sweden,Switzerland,France,Denmark,United Kingdom,United Kingdom,Denmark,Denmark
Call: Smart Airports (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 15426039.75
EU funding (EUR): 11957081.0
Participants: 18
Project status: SIGNED

The ALIGHT project will address the global need to reduce greenhouse gas (GHG) and other air emissions in order to adapt to climate change and promote a sustainable future. It will do so through the development and demonstration of two sustainable solutions to be implemented in Copenhagen Airport (the Lighthouse airport), namely 1) the supply, implementation, integration and smart use of sustainable aviation fuel (SAF) and 2) the development, integration and implementation of smart energy system (including renewable energy sources, energy storage and energy management). On the SAF side, ALIGHT will tackle a current challenge, namely the smart, sustainable and cost effective handling of SAF in the operational context of a major airport. The project will address the SAF chain from procurement to integration and demonstration and ensure compliance with all relevant criteria, including sustainability. Within the area of smart energy, ALIGHT will address the full chain from system mapping, energy supply (including renewable energy, energy storage and geothermal energy), smart energy management to planning and demonstration in passenger transport, ground handling equipment and buildings (including heating, cooling and electricity). Field performance monitoring will be performed on aircraft exhaust-, vehicle- and air quality level. Sustainability and the reduction of GHG and other air emissions will be addressed throughout, and all components will be subject to relevant sustainability requirements. ALIGHT will bring forward the necessary solutions, knowledge, guidelines and best practice recommendations in comprehensivWith the Lighthouse project, CPH as Lighthouse with two fellow airports, will demonstrate energy-efficient, climate-friendly, fossil-free and smart solutions in preparation for upcoming massive investments in, among other things. infrastructure for biokerosene airplane fuel and electrification of vehicles and machines both in- and outside the airport.

Keywords: sustainable aviation fuel,smart energy,management,digitalisation,database,digital twin,intelligent charging,greenhouse gas monitoring,certification,replication toolbox,handbook,guideline
RNA NanopartIcles for Cardiac rEgeneration (NICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy,United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-10-01
End date: 2023-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 115000.0
Participants: 2
Project status: CLOSED

Prompt coronary catheterization and revascularization have dramatically improved the outcome of myocardial infarction, but also have resulted in a growing number of survived patients with permanent damage of the heart, which frequently leads to heart failure. This condition is now common, expensive and lethal. All currently available drugs for heart failure are aimed at improving residual cardiac performance, while none counteracts the loss of cardiomyocytes. We aim at developing an innovative biological drug that induces cardiac regeneration after myocardial infarction by stimulating endogenous cardiomyocyte proliferation. Our past work using high throughput screenings has identified a human microRNA (hsa-miR-199a-3p) that is effective at stimulating cardiomyocyte proliferation. Expression of this microRNA in the heart using an AAV vector leads to cardiac regeneration and improvement of cardiac function after myocardial infarction in both mice and pigs. A single administration of hsa-miR-199a-3p as a synthetic molecule is sufficient to stimulate cardiac repair. This project now aims at formulating this chemically synthetized miRNA into a lipid nanoparticle (LNP199) that is fully biocompatible, protects the miRNA from degradation and promotes its cardiac intracellular delivery. By experiments in large animals, the project will define the optimal route for LNP199 delivery by comparing three different routes of administration to the heart, any of which can be adopted for application according to standard clinical procedures. Delivery of LNP199 in pigs after ischemia reperfusion followed by cardiac MRI monitoring over time will provide information on the efficacy of this treatment in a clinically applicable scenario and highlight possible side effect. Among the advantages of this regenerative approach are one-off administration, relative ease of delivery according to standard interventional procedures, stability once manufactured and likely affordable cost.

Keywords: cardiac regeneration,cardiomyocyte proliferation,innovative therapies,microrna,myocardial infarction,nanoparticles
Intelligent Electrochemical Cooling Water Softening System (I-SOFT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cooling Tower (CT) Water systems are widely used in industrial and commercial sectors to cool processes and HVAC systems. CT system cooling water must be treated to avoid scaling, corrosion and bio-contamination that cause high economic losses. Traditional water treatments, chemical additives and water blowdowns, are becoming obsolete. Chemical additives are hazardous and banned by increasingly stringent regulations. Blowdowns are unaffordable since water is becoming a precious resource. New technologies are needed to perform water treatment in an affordable and clean way. Recently, electrochemical softening has appeared as a non-expensive and clean alternative. However, its widespread use is being ballasted by the lack of reliable monitoring systems, which optimizes the energy supplied to prevent corrosion. I-SOFT is a ground-breaking approach to on-line monitor the scaling events in the CT system with an innovative feedback control that regulates the power supply output, providing a full and highly accurate removal of scale and bio-fouling without promoting corrosion. It is based on our wide know-how in electrochemical systems, with more than 5.000 installations globally, which has produced 50% in water savings, 24% reduction in OPEX and 100% reduction in chemicals. However, I-SOFT will improve that: 25% and 15% extra water and energy savings, respectively, resulting in an average cost reduction of €500.000/year in common industrial plant. I-SOFT has been developed by UET, a company founded by David Sherzer, one of the 100 most Influential people in Israel in the environmental sector.

Keywords: cooling tower,water treatment,scaling,corrosion,bio contamination,chemical additives,electrolysis
JUMPAIR: Decubitus Ulcers Diseases Diagnoses by means of Smart Anti-Decubitus System based on known Ulcers Activity Biomarkers (JUMPAIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project JUMPAIR will benefit a large number of patients who has suffered decubitus ulcers or they are running the risk to suffer it by remotely monitor ulcers biomarkers to improve early diagnoses, treatment and providing alerts at critical situations. JUMPAIR project meets the objectives of the PH 12 topic: clinical validation of known DeU diagnoses biomarkers by means of an innovative medical device which a potential wider clinical deployment in very short time. First of all, there is no decubitus system in the market able to monitor the onset of decubitus ulcers and provide alerts in real time to the hospital for long-term diseases, including the implementation of intelligent algorithms and an innovative integrated measurement system embedded in textiles. Secondly, the prototype will be enhanced and validated by means of clinical trials in real conditions in the Hospitals setting our European collaborators network. The final anti-decubitus system will contribute to decrease the healthcare expenditure preventing the onset of decubitus and avoiding unnecessary hospitalizations and therapeutic treatments. We believe that there is an unmet need in that field, and the final systems allows a preventive and therapeutic care of decubitus ulcers having a great impact for physicians and patients who deal with this critical decubitus ulcers disease.

Keywords: smart anti decubitus system,ulcers biomarkers,decubitus ulcers diagnoses
Sustainable Production of Industrial Recovered Energy using energy dissipative and storage technologies (SUSPIRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Spain,Spain,Italy,Belgium,Lithuania
Call: New technologies for utilization of heat recovery in large industrial systems, considering the whole energy cycle from heat production to transformation, delivery and end use (H2020-EE-2015-1-PPP, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 3722017.5
EU funding (EUR): 3722016.75
Participants: 11
Project status: CLOSED

SusPIRE project assimilates in its conception the sustainable energy use challenge described in the European SETPLAN and in SPIRE road map. It addresses its efforts to energy intensive industries and within this segment market to energy recovery from residual heat streams. To achieve this goal a two clearly differentiated working areas will be key aspects of this project. Technology area will include the development of materials and equipments. New Heat Transfer Fluids (HTF) and Phase Change Materials (PCM) will be the base for manufacture high efficiency heat exchangers in terms of energy capture and storage. Two Borehole Thermal Energy Storage (BTE) areas(low temperature range (30-50ºC) and medium (50-80ºC) will support a energy cascading concept where energy will be sequentially used and finally stored for further use or commercialized to third parties. The methodology aspects of this projects wants to establish a framework to foster the energy commercialization of surplus energy . Living areas , symbiosis with other companies in industrial parks, sports centers.. will beneficiate from cheaper energy, environmental impact reduction and social acceptance of energy intensive industrial activities. The coordination of the manufacturing and the energy recovery processes will be carried out by means of a smart methodology. A protocol definition software will deploy actions to create best practices in terms of process adjustment and operating instructions. Management concepts based on energy recovery rate as Key Process Indicator (KPI), will be integrated into the decision making mechanism of the company assuring permanent advances in this field of activity in forthcoming years.

Keywords: industrial heat recovery,energy intensive industry,underground thermal storage,heat exchanger,residual heat streams
Wiring synaptic circuits with astroglial connexins: mechanisms, dynamics and impact for critical period plasticity (AstroWireSyn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: CLOSED

Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial elements of the brain circuitry that control synapse formation, maturation, activity and elimination. How do astrocytes exert such control is matter of intense research, as they are now known to participate in critical developmental periods as well as in psychiatric disorders involving synapse alterations. Thus unraveling how astrocytes control synaptic circuit formation and maturation is crucial, not only for our understanding of brain development, but also for identifying novel therapeutic targets. We recently found that connexin 30 (Cx30), an astroglial gap junction subunit expressed postnatally, tunes synaptic activity via an unprecedented non-channel function setting the proximity of glial processes to synaptic clefts, essential for synaptic glutamate clearance efficacy. Our work not only reveals Cx30 as a key determinant of glial synapse coverage, but also extends the classical model of neuroglial interactions in which astrocytes are generally considered as extrasynaptic elements indirectly regulating neurotransmission. Yet the molecular mechanisms involved in such control, its dynamic regulation by activity and impact in a native developmental context are unknown. We will now address these important questions, focusing on the involvement of this novel astroglial function in wiring developing synaptic circuits. Thus using a multidisciplinary approach we will investigate: 1) the molecular and cellular mechanisms underlying Cx30 regulation of synaptic function 2) the activity-dependent dynamics of Cx30 function at synapses 3) a role for Cx30 in wiring synaptic circuits during critical developmental periods This ambitious project will provide essential knowledge on the molecular mechanisms underlying astroglial control of synaptic circuits.

Keywords: neuroglial interactions,astrocytes,synapse,plasticity,criticial period