Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deep-Body Wireless Bioelectronics Enabled by Physics-Based Bioadaptive Wave Control (BESSEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1499973.0
EU funding (EUR): 1499973.0
Participants: 1
Project status: SIGNED

Wireless medical devices can be implanted in the body to monitor health and to deliver therapies. Recent advances in biosensors, neural interfaces, biotechnology, microelectronics, and improved surgical techniques enable a vision of minimally invasive battery-free bioelectronic implants that can perform a wide range of medical and research tasks. Examples include biosensing for an early detection of health anomalies, recording and precision stimulation of central and peripheral nervous systems, implantable labs-on-a-chip, surgical microbots, and so on. A key scientific challenge lies in how these devices can be powered and controlled from outside of the body. Existing wireless solutions remain limited in their ability to transfer energy and data. These limitations result from the difficulty in controlling electro-magnetic waves in the human body – a dynamic, heterogeneous, and lossy medium. The objective of this proposal is to develop bio-adaptive wave control technologies that overcome these challenges to enable efficient powering and precise control of mm/μm-scale deep-body bioelectronics. To accomplish this, we will (1) focus on the fundamental studies of waves and their control in complex and dynamic anatomical media; (2) develop new reconfigurable architectures of conformal radiating surfaces for the practical implementation of the developed wave control methodologies, and (3) demonstrate clinical utility by fully wireless recording and modulation of the pancreatic nerve activity in an anesthetized porcine model through dynamic wave control. The proposal relies on interdisciplinary track-record of the PI in bioelectronics and neural interfaces, wave physics and computational electromagnetics, conformal radiating structures and wireless power transfer. BESSEL consolidates these skills and enables conducting research on highly capable deep-body wireless bioelectronics with high translational potential.

Keywords: implantable devices,wireless bioelectronics,wireless power transfer,wave control devices,conformal radiating structures
Floodplain Weathering (FloW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1498738.75
EU funding (EUR): 1498738.75
Participants: 1
Project status: SIGNED

Chemical weathering of rocks is central to Earth’s biogeochemical cycles. It exchanges CO2 with the atmosphere, balances CO2 emission from the mantle, and stabilizes Earth’s climate. Years of research have established data and models of weathering in eroding landscapes, because erosion supplies unweathered rocks to the surface of the Earth. However, the sediment eroded from mountains can continue to weather during temporary storage in wide floodplains. Recent estimates indicate that floodplain sediments may contribute over 50% of the global weathering flux; yet, we do not have a framework to quantify floodplain weathering or predict its sensitivity to climate and tectonics. A quantitative understanding of floodplain weathering will allow building new models of the global carbon cycle, and it will increase the accuracy of tools to predict Earth’s response to natural and anthropogenic perturbations in CO2. I propose an ambitious, innovative, and multidisciplinary research program to develop, quantify, and test a model for weathering fluxes as a function of sediment transport and storage on floodplains. The predictive power of the model will be tested against new data from floodplains influenced by different tectonic and climatic boundary conditions. Thus, FloW will yield a novel framework to link physical and chemical mass fluxes across Earth’s surface, potentially transforming the power of simulations of Earth’s carbon cycle and climate evolution.

Keywords: carbon cycle,chemical weathering,sediment transport,sediment residence time
Programmable Nanomatter (PRONANO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1499153.0
EU funding (EUR): 1499153.0
Participants: 2
Project status: SIGNED

PRONANO will develop both theoretical and experimental methods to design autonomous nanoscale units that are able to carry out logic operations in order to self-assemble into distinct structures determined by an external stimuli. The nanounits will be programmed to assemble via a controlled self-assembly kinetic pathway, ultimately enabling programmable nanomatter. We will develop new algorithmic framework that will find the optimal set of interactions and logic gate controls required for the coordinated function of nanoparticles. We will use multiscale coarse-grained modeling to design and simulate interactions of nanostructures with the capabilities to carry out computation and communication with other nanoparticles in order to act as a programmable swarm. We will realize these nanostructures experimentally using DNA nanotechnology, creating a system that can dynamically react to an externally introduced stimulus that induces them to self-assemble into target finite-sized structures. This work will create new methods for nanotechnology that combine optimization theory, molecular simulations and experiments to study the kinetics and thermodynamics of hierarchical multicomponent assembly. As part of this effort, we will develop universal design rules to obtain a set of DNA nanostructures that can carry out computation and communication in order to achieve specific nanostructures as instructed by a biomolecule (DNA, RNA, or protein) that will act as external stimulus. Thus we will create a system which is both computationally tractable and can be realized and iterated experimentally, opening new venues for nanorobotics and self-organized systems. It will enable nanoscale construction of complex three-dimensional structures as a response to external conditions, with applications in molecular manufacturing, therapeutics, diagnostics and smart material construction.

Keywords: dna nanotechnology,self assembly,coarse grained modeling
MSCA fostering balanced mobility flows in Europe (MSCA2021SI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Slovenia
Call: Presidency event: MSCA Conference under Slovenian Presidency (HORIZON-MSCA-2021-SLOVENIAN-PRESIDENCY-IBA, 2021)
Start date: 2021-10-01
End date: 2022-04-30
Duration (months): 7.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The conference will aim to strengthen the impact of the MSCA programme in achieving the goals of the New ERA and will address the unbalanced mobility flows that still represents a major challenge for Member States and contributes to the research and innovation divide within the EU. Return migration and reintegration processes of MSCA researchers after the end of their project to the countries of origin will be the main topic of the conference. At the conference, we will discuss and elaborate the multidimensional MSCA talents mobility flows among various MSCA stakeholders, including researchers. We will focus on the diversity of mobility flows and the different aspects and effects of MSCA return mobility and reintegration processes in countries of origin to achieve well-balanced mobility flows. The first objective is to raise awareness of the importance of return mobility and reintegration processes in order to strengthen the balanced mobility flows of MSCA researchers. The second objective is to show the examples of existing good practices as well as barriers, instruments, and policies to promote the return migration and reintegration processes of MSCA fellows after the end of their project. The conference will be a venue for MSCA researchers and stakeholders to share, discuss and elaborate on their experiences, challenges and proposals. The third objective is to provide recommendations for the implementation of MSCA return migration and reintegration tools and policies at EU, Member State, research organisation and individual levels. In line with the conference programme, our discussions will focus on the importance of additional measures taken by Member States to create targeted training and career opportunities for researchers, to improve working conditions and the working environment, to support investment in human capital, scientific and technological infrastructures to attract researchers back after their fellowships.

Keywords: msca,mobility,research careers,conference
Connecting healthtech innovation ecosystems for user-centred and business-driven entrepreneurial education propelling next-generation digital health solutions (HealthEConnect)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal,Denmark,Belgium
Call: Expanding Entrepreneurial Ecosystems (HORIZON-EIE-2022-SCALEUP-01, 2022)
Start date: 2023-01-15
End date: 2025-07-14
Duration (months): 30.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 5
Project status: SIGNED

Rising costs, resource pressures, and an increase in chronic diseases, together with the challenges posed by an ageing population have exerted significant pressure on Europe to improve its healthcare and put forward health-related technological advances. While much has been done inside healthcare institutions (hospitals and clinics) to stimulate innovation, far less has been done outside the traditional healthcare frameworks to foster the development of innovative health solutions. In this context less conventional players, like educational establishments and training providers, have proven to play an increasingly important role in developing an entrepreneurial spirit and driving innovation. Nevertheless, the typical science education curriculum (including the medical curriculum) does not integrate any instruction on innovation or entrepreneurship which leaves a gap. Hence, there is a strong need for education offers that can equip future health innovators with particular mind- and skillsets and with the capacity to shape tomorrow´s healthcare. To respond to the unmet need, several health care innovation and entrepreneurship education and training offers with novel, real-life approaches involving ecosystem members, have emerged in the past years both in (e.g. in Denmark) and outside Europe. In order to close the innovation gap across Europe, it is critical to foster the best practices and innovation resource flows between ecosystems at different development levels. HealthEConnect will strengthen the cooperation between two innovation ecosystems: the healthtech innovation ecosystem of the Lisbon region (PT) and the one of Hovedstaden (DK), to support the rise and growth of next-generation healthtech companies through a co-designed, user-centered and entrepreneurial-driven healthtech innovation and entrepreneurship educational offer launched in Lisbon capitalising on best practises and platforms to sustain collaboration and resource flows between ecosystem members.

Keywords: health tech ecosystem development
Demonstration of battery metals recovery from primary and secondary resources through a sustainable processing methodology (METALLICO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Germany,Poland,Finland,Norway,Chile,Italy,Greece,Portugal
Call: Innovative solutions for efficient use and enhanced recovery of mineral and metal by-products from processing of raw materials (IA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 13064159.5
EU funding (EUR): 11798783.25
Participants: 23
Project status: SIGNED

The European Union has underexploited potential to produce critical raw materials (CRM) and special metals, as stated in the Study on the EU’s list of Critical Raw Materials (2020). Concretely, the battery sector is considered as a key strategic sector for the EU due to the increased use of batteries in different important sectors such as electric mobility. Thus, METALLICO proposal presents a new opportunity for the European Union. It is composed by an strategic consortium along the value chain, including mining and industrial sites with primary and secondary sources of critical and battery metals (Li, Co, Cu, Mn, Ni); experienced partners to pilot novel processes for producing battery-grade materials based on previous projects and activities; industrial and SME end-users in the battery, cement, paint, and ceramic sectors; and partners to demonstrate the social-license-to-operate (including the support of government bodies), sustainability and commercial chances that the solution represents. Worldwide, these battery metals are predominantly in Chile, Australia, South Africa, China, and The Democratic Republic of Congo, representing a high risk for the EU in terms of supply shortage. For example, in the case of Li, the EU import reliance is 87% for lithium concentrates and 100% for refined compounds as there is no domestic refining . METALLICO includes 4 cases studies in the EU to recover: battery-grade Li2CO3 from a primary spodumene/lepidolite/petalite deposit; Co concentrates and battery-grade CoSO4 from a mine secondary resource (CLC); and Cu, Co, Mn, and Ni concentrates from metallurgical slag from a Pb refining company (KHGM) and secondary mine tailings (THARSIS). Upscaling of sustainable and innovative upstream and downstream processes will demonstrate the techno-economic recovery and production of these critical and important metals for the EU.
The early ticking of the central circadian pacemaker: when and how (StarTicking)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1955875.0
EU funding (EUR): 1955875.0
Participants: 1
Project status: SIGNED

The 24-h (circadian) timing system develops during the perinatal period and rules our physiology later in life. It has the essential task of anticipating daily recurring changes in the environment (day/night) to find the best time for each molecular and cellular process. It is organised hierarchically, with a master pacemaker in the hypothalamic suprachiasmatic nucleus (SCN), which is able to perceive environmental light and tell the body what time is it. Our modern 24/7 lifestyle favours a disruptive environment for the circadian system, which is especially negative during pregnancy. We have found, in mice and pre-term infants, that when mothers are exposed to glucocorticoids (GCs) at the wrong time of day, the offspring show behaviour disorders later in life. Our mechanistic findings showed for the first time, a role of the foetal clock before birth, challenging the view on the clock being immature and non-functional. StarTicking proposes to answer a long-standing question in the field: When and how the circadian clock starts ticking. With a multidisciplinary and integrated approach, we will go beyond the state-of-the-art to understand mechanistically the development of the central circadian pacemaker in mice and humans. We will investigate: 1) How the SCN forms by a detailed assessment of the developmental trajectory of the mouse SCN with single cell resolution. 2) When the SCN becomes functional by testing a yet unexplored player: Astrocytes as drivers of the gain of functionality of the mouse SCN. 3) What the influence of the early environment on the human SCN maturation is. The generation of a human SCN organoid will allow us to test maternal signals in vitro with high-throughput. We will link mechanistic findings to the development of SCN-driven rhythms in a cohort of pre-term babies. StarTicking will provide ground-breaking mechanistic evidence and valuable knowledge to alleviate the behavioural consequences of the circadian disruption early in life

Keywords: circadian clock,suprachiasmatic nuclei scn,mouse,human,development,pregnancy,early environment,premature babies,glucocorticoids,neurons,astrocytes,organoids,foetal brain,single nuclei rna seq,organotypic,per2venus,in utero electroporation,ex vivo electroporation,lineage tracing,
The first Total Artificial Heart (TAH) that truly mimics the human heart and has the potential to revolutionise the market (ArtOfHeart)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-04-01
End date: 2026-03-31
Duration (months): 48.0
Total project cost (EUR): 38241965.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The Realheart TAH system (RTS) is the first total artificial heart designed to mimic the structure and function of the human heart. Its unique patented construction of two atria and two ventricles is separated by an atrioventricular plane which contains the valves, enabling to pump blood naturally whilst reducing the risk of blood flow complications. RTS is designed to be efficient (12h battery), silent, lightweight (2.5kg), easy to implant and automatically adapt to different (physiological) activity levels. It consists of two identical artificial heart pumps, a drive line and an intelligent control unit. RTS is connected via a cable through the skin to a controller carried together with two batteries in a belt around the waist. RTS is aimed as a permanent solution for end-stage heart failure patients, but also for patients waiting for a transplant. Realheart will complete GLP animal trial, clinical trial preparatory activities and first-in-man (EFS) trial during the EIC project.

Keywords: total artificial heart,cardiothoracic surgery,congestive heart failure
Mapping the Virological Consequences of 5500 years of Domestication and Shifting Breeding Practices in Horses and Donkeys (VIRODOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

The emergence of animal domestication and farming practices during the last 10,000 years is thought to have enhanced humans' exposure to infectious diseases, but the consequences of these developments for the health of domesticated animals themselves have been largely overlooked. Understanding the long-term effects of domestication and breeding practices on the epidemiology and evolution of animal pathogens is yet of foremost importance given current concerns regarding modern farming practices and their impact on animal and public health. Recent major advances in sequencing and biomolecular techniques have allowed the recovery of rare and degraded DNA molecules from ancient biological samples, including those of pathogens which can persist in the remains of their hosts for millennia. Here, we will leverage a massive collection of ancient equine DNA (aDNA) libraries spanning more than 50,000 years to investigate the past epidemiological and evolutionary dynamics of DNA viruses in horses and donkeys from the earliest stages of domestication to modern days. An innovative approach will be implemented for the systematic enrichment of viral DNA in aDNA libraries prior to sequencing, to maximize viral detection sensitivity. Metagenomic analyses of resulting datasets will allow characterizing ancient equine viromes and their variations through time. Ancient viral sequences will be used for genomic and phylodynamic analyses to reconstruct past viral genomic changes, geographical spread and transmission dynamics. Inferred patterns will be interpreted in the light of detailed knowledge about horse and donkey's domestication and management history which has been generated in recent years. VIRODOM will provide major insights into the evolutionary history of important equine pathogens which remain understudied and contribute to the development of an integrative, One Health vision of infectious disease's history and evolution.

Keywords: ancient dna,virus,equid,domestication,breeding