Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the molecular basis of immunological memory in human T cells (Remin-T)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

T lymphocytes are essential for immunity to pathogens and malignancies. Activated T cells can retain a ‘memory’ imprint of their adversary (e.g. a virus), enabling them to respond more rapidly and vigorously to any subsequent encounters. While memory T cell formation is critical for successful vaccination and anti-tumor immunity, dysfunctional memory T cells are a common feature of human disease, including allergy, autoimmunity and cancer. T cell activation emerges from changes in gene expression dictated by intricate chromatin dynamics. Recently, 3D chromatin folding emerged as a key regulator of transcriptional control by ensuring correct communication between regulatory elements and their target genes. How memory T cells leverage three-dimensionally organized chromatin configurations to achieve rapid re-activation of specific inflammatory genes is unclear. Hence, the molecular mechanisms that control and maintain immunological memory remain poorly understood. To address this issue, I propose an innovative molecular strategy to dissect immunological memory in primary human CD4+ T cells that combines cutting-edge genome-wide analyses of gene expression, chromatin state and three-dimensional (3D) genome folding with CRISPR/Cas9-based functional assays. This approach will generate the first integrated multidimensional epigenome atlas of a human T cell memory recall response, yielding molecular circuits of genes, regulatory elements and biological pathways underlying human immunological memory. Multimodal single cell genomics assays will reveal the nature of transcriptome-epigenome crosstalk in individual T cells and the heterogeneity of memory recall. These insights will force a breakthrough in our understanding of how human immune cells maintain specific transcriptional programs for launching rapid and tailored responses upon re-activation, and how this feeds into susceptibility to develop disease.
Boosting Efficiency and Stability of Tin-Lead Perovskite Photovoltaics with Chemically Smart Device Architectures (SAMper)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Perovskite photovoltaics offer a low-cost, high-efficiency solution to speed up the transition to net-zero emissions. In particular, tin-lead perovskite solar cells have ideal optical properties for peak performance. However, their large-scale use is hampered by stability issues at perovskite surfaces, i.e., oxidation, vulnerable defects, and chemical mismatch with ordinary charge transport layers in solar cells. Self-assembled monolayers (SAMs) are alternative transport layers that allow the manipulation of critical interface regions, yet their use in tin-lead perovskite photovoltaics remains in its infancy. Careful choice of SAM functional groups, molecular structure and redox chemistry are key to tackle perovskite limitations. SAMper will develop ultrastable and highly efficient tin-lead perovskite solar cells by designing SAM device architectures with interface-specific smart functionality. Defect-passivating, perovskite-healing and oxidant scavenging SAM moieties will afford the targeted properties, as will be demonstrated via structural, chemical and electrical interface analysis. Top SAM-based devices will be tested outdoors to demonstrate their excellent durability and efficiency, comprising the first example of tin-lead perovskite solar cell testing under real-world conditions and paving the way towards their commercial deployment. SAMper contributes towards clean energy in alignment with European Green Deal decarbonisation targets. The project will further the researcher's excellence and career prospects via training on cutting-edge multidisciplinary research. Knowledge transfer with the supervisor will foster the researcher's scientific independence via key management skills. The secondment for outdoor tests will facilitate international synergies. Project outputs and datasets will adhere to FAIR principles, aiding the benchmarking of the technologies herein. Various activities will disseminate these results, and foster STEM vocations among local youth.

Keywords: perovskite solar cells,tin lead perovskite,stability,emerging photovoltaics,self assembled monolayers
Windows of microbial activity in deserts afforded by non-rain water (WinMicAct)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2617968.0
EU funding (EUR): 2617968.0
Participants: 2
Project status: SIGNED

Soil microorganisms are essential drivers of ecosystem processes in drylands that cover ~40% of the Earth’s landmasses. It is widely accepted that microbial activity in arid deserts is confined to rare, short and unpredictable rain pulses. Yet, water could be available for soil microorganism by other processes, such as dew formation, fog deposition and water vapor adsorption. These so-called non-rain water inputs represent significant sources of water, as they are more frequent and reliable. Yet, it is unknown if desert soil microorganism can utilize these water sources for reactivation, nor the associated microbial activities they facilitate and their overall contribution to microbial-driven ecosystem processes. WinMicAct will challenge the rain-centered view of desert microbial activity. I hypothesize that desert microbial communities can use the minute water input provided by non-rain water for reactivation. WinMicAct pushes the boundaries of molecular omics and microbial activity analysis to detect reactivation down to the lowest possible water availabilities. Utilizing spatial upscaling, WinMicAct will estimate the contribution of these microbial activities (respiration, CO2 and N2 fixation) to the ecosystem level. WinMicAct will further reveal the importance of different water sources for survival and thus maintaining desert soil biodiversity that is crucial for ecosystem functioning. Finally, WinMicAct is highly relevant in light of climate change, as future scenarios predict changing patterns of rain and non-rain water inputs. With the knowledge gained in this project on microbial processes driven by the different water sources under climate change predictions, WinMicAct provides the foundation for future investigations and modeling of climate change effects on dryland ecosystem processes. Together, WinMicAct will generate ground-breaking knowledge on non-rain water driving microbial activities and will be a major step forward in arid ecosystem research.

Keywords: desert soil microbiology,bacteria archaea,microbial survival and reactivation,microbial diversity,non rain water input,ecosystem processes,climate change scenarios
An anthropological study of truth wars from marginalized standpoints (DE-CRIPT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1492305.0
EU funding (EUR): 1492305.0
Participants: 2
Project status: SIGNED

In today’s age of post-normal science and fragmentation of the public sphere, truth itself has become an increasingly contentious and contested concept. De-CRIPT will introduce theoretical and methodological innovations into research on truth-making processes to expand current understandings of the nexus between controversial truth claims (particularly those labelled conspiracy narratives) and socioeconomic disadvantage. Comparing four paradigmatic communities subject to longstanding or newly-emerging processes of downwards social mobility across four different countries of Western Europe, the project seeks to understand: - the conflicts between mainstream and conspiracist discourses in the online sphere and in everyday offline interactions; - the conditions that make controversial truth claims acceptable or appealing among disadvantaged groups; - connections and disconnections between the communicative intentions of the main creators and propagators of controversial truth claims online, on the one side, and the pragmatic uses of the same claims by ordinary social actors in everyday life, on the other. Theoretically, De-CRIPT will introduce into research on truth-making processes: 1) the philosophical tradition of pragmatism (with its linguistic and sociological legacies) in order to focus on social actors’ pragmatic uses of truth claims to justify their practices and/or produce specific effects, and 2) a feminist epistemological lens, which examines processes of knowledge production and circulation by paying attention to different forms of oppression, in order to expand current understandings of the conditions of acceptability of controversial truth claims among low-status groups. Methodologically, it will encompass both conspiracy narratives and the narratives opposing them, across both digital and non-digital environments, by combining critical discourse analysis of online sources and feminist ethnography.

Keywords: conspiracy theories social inequalities social conflicts feminist epistemology speech acts practice theory
Decoding the Molecular Logic of GPCR Signaling (SignAlloMod)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1499389.0
EU funding (EUR): 1499389.0
Participants: 1
Project status: SIGNED

G protein-coupled receptors (GPCRs) are key to human physiology and disease, yet their signaling remains enigmatic. What we do know is that GPCRs signal by means of allosteric communication across the cell membrane, acting as logic gates that relay signals from extracellular ligands to various intracellular transducers. Nonetheless, the logic underlying GPCR signaling at the molecular level is not yet understood. This is particularly true of three key signaling phenomena: ligand efficacy, biased signaling, and allosteric modulation. In SignAlloMod, we will address this challenge and investigate the logic of transmembrane signaling through GPCRs at the single-molecule level. We will develop a new single-molecule microfluidic method that enables simultaneous measurement of transducer binding and receptor activation states, making rigorous, quantitative models of GPCR allostery experimentally accessible. This will allow us to separate, for the first time, ligand-specific from transducer-specific effects in GPCR signaling, ultimately enabling us to decode the molecular logic of GPCR signaling. We will use prototypical GPCRs to establish our approach and to study ligand efficacy, biased signaling, and allosteric modulation. The quantitative insights into ligand-specific and transducer-specific effects afforded by SignAlloMod will redefine our understanding of GPCR signaling. SignAlloMod will provide pharmacological ligand profiles with unprecedented detail, opening new horizons for drug discovery and pharmacological intervention guided by physical principles.

Keywords: g protein coupled receptors,membrane receptors,transmembrane signaling,single molecule fret,microfluidics,native nanodiscs
The so-called mos gallicus: In Search of a Transnational History of the “French method of teaching law” (ISTHisFrench)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1868438.0
EU funding (EUR): 1868438.0
Participants: 1
Project status: SIGNED

Legal history, as taught in faculties of law, tends to overemphasise the national framework, leading to the knowledge transmission that suffers from old-fashioned nationalistic biases. To overcome this bottleneck, I will challenge one of the most nationalistic reductions of a major legal phenomenon: the Legal humanism of the Renaissance. This European intellectual movement, with immense legal and extra-legal repercussions, is still presented today as mainly French, as shown by the expression commonly used to designate it: the mos gallicus jura docendi (French method of teaching law). Understanding the mos gallicus in its original transnational dimension will thus establish the simultaneous development of humanist legal thought from a pan-European perspective and reveal why and how the European Legal humanism has been called the “French method of teaching law”. The aim of this ERC is to demonstrate, by placing the Legal humanism in its European dimension, the construction of legal nationalisms hidden behind the expression mos gallicus. To achieve this, three novel objectives will be pursued: to map the representation of the mos gallicus as it has been shaped by historiography; to determine, through the study of the mos gallicus, how legal nationalisms were shaped since the Renaissance Legal humanism; and to place the mos gallicus in its original European dimension. The ambitious outcomes of this project will be a historiographic database available to the scientific community; papers redefining both mos gallicus and legal nationalism, through the case studies of France and Great Britain; and monographs questioning the relevance of the expression “French method of teaching law”, both on a micro-historical scale by the three doctoral theses, and on a macro-historical scale by the final book. These works will contribute to really measuring, at a European level, the role played by the Legal humanism in the construction of national legal orders and nation-States.

Keywords: legal history legal nationalism legal thought legal humanism of the renaissance
Transforming industrial part replacement and after sales through visual search and synthetic images (Nyris)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 3098125.0
EU funding (EUR): 2168687.5
Participants: 1
Project status: CLOSED

Industrial manufacturers and their customers need to identify and retrieve spare parts quickly and efficiently. Our visual search engine allows any spare part to be found in manufacturers’ catalogues by simply taking or sharing an image of it. It has proven to be by far the most accurate tool compared with several large competitors. Most importantly, we can overcome the key hurdle to visual searches for industrial applications: the availability of images for AI network training. Large manufacturers struggle to undertake the time-consuming and expensive effort of producing these images for all spare parts and machines through manual photography. We are the only company in the market who can produce synthetic images from CAD data, which outperform real data in training and search accuracy. Moreover, we can onboard customers in a matter of minutes. At Nyris, we give search the power of sight.

Keywords: ocr,industrial spare parts,synthetic data,visual search,generative adversarial networks,image recognition,edge detection,image generation
New generation of substrates to harness the full power of microorganisms (Bac3Gel)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-07-01
End date: 2025-10-31
Duration (months): 28.0
Total project cost (EUR): 2143875.0
EU funding (EUR): 1500712.0
Participants: 1
Project status: SIGNED

Bac3Gel is a biotech company that develops and distributes advanced substrates to harness the full power of microorganisms. Bac3Gel substrates are the first that combine three-dimensionality with gradients of oxygen, nutrients and physical properties to allow the growth of complex microbial communities and currently unculturable bacteria that depend on these microenvironments to thrive. Our advanced substrates have the power to revolutionise the status quo of microbiology and unlock innovative bacteria-based solutions to solve challenges across multiple bio-based industries. Bac3Gel mission is to ultimately foster the discovery of new antibiotics and bio-based solutions to feed the ever-growing demand for innovative treatments, as well as the development of microbiome-modulating drugs to address 90% of diseases linked to human microbiome imbalance.

Keywords: bioproducts products that are manufactured using biological materials as feedstock,unculturable bacteria,gut,microbiome
Interfaces for Democratic Participation: Deliberation, Mobilization and Contestation Since the Onset of the Covid-19 Pandemic (INTERFACED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: United Kingdom,Estonia,Spain,Romania,Italy,Denmark,Germany,Ireland,Belgium,Hungary
Call: Protest politics and cultures of opposition in democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2999942.25
EU funding (EUR): 2999937.0
Participants: 12
Project status: SIGNED

Amidst the rise in protest, democratic and scientific mistrust, as well as growing societal divisions and inequalities heightened by the Covid-19 pandemic, INTERFACED investigates the diverse forms of political participation that have arisen subsequently. We approach the period since the onset of the pandemic as an opportunity to contribute to the destination Innovative Research on Democracy and Governance of the Work Programme, to its cardinal goal to reinvigorate democratic governance and empower active and inclusive citizenship. We do so by distinguishing participation interfaces between citizens and representative institutions to then investigate their capacity to include citizens within decision-making and governance. INTERFACED pursues seven specific objectives that move the analysis of these interfaces beyond the state-of-the-art with the aim to enhance relations between citizens and governments. The objectives will be attained with a comprehensive methodological apparatus—combining large-scale surveys and experiments with computational, ethnographic, textual and comparative qualitative methods. Together with the topical selection of a diverse set of eight European countries and Tunisia—spanning multiple forms of opposition, including opposition to authoritarianism—INTERFACED will thereby offer a systematic and inclusive basis from which to produce new and innovative research findings, and from which to scaffold policy recommendations to maximize the mobilization and minimize the demobilization of the least engaged and most disadvantaged social groups.

Keywords: interfaces,mobilization,demobilization,disengaged,disadvantaged
Clone-based full-length RNA-seq for early diagnosis of cancer (CancerFLCloneSeq)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-12-01
End date: 2024-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Intra-tumor genetic heterogeneity imposes a great challenge on cancer therapy. Resistance to molecularly targeted therapies and chemotherapy can arise from selective growth of pre-existing sub-clones that carries drug-resistance mutations, altered metabolic and/or epigenomic states, providing a survival advantages. Early detection of these subclonal states can thus significantly aid cancer therapy. However, attempts to profile various types of primary cancer cells using single-cell techniques are relatively poor. One of the major limitations is the significant dropout rate (i.e., loss of alleles) observed in single-cell RNA-seq. It severely affects our ability to leverage single cell RNA-seq to accurately profile somatic mutation, to reveal cancer driver mutation and even extract low/mid-level expressed genes and splicing. For that reason, most of the efforts to expose mutations that are critical for cancer growth and can subsequently lead to more effective treatment are based on the sequencing of bulk populations. However, due to the noise introduced by PCR, sequencing and alignment processes, bulk sequencing is limited to identify mutations with a frequency higher than 5%. Here we propose to develop a novel 3D clone-based full-length RNA-seq profiling technology. A preliminary version of this technology for digital profiling of mRNA, already allowed us to significantly improve sensitivity comparing to gold-standard single-cell RNA-seq methods. Using this preliminary version on clones of lung adenocarcinoma, we revealed novel cancer stem like subpopulation that could not be detected using regular single cell RNA-seq maps. Altogether, improving the ability to detect rare mutations (<5%), splicing events and transcriptional variation between cancer cells, will be an extremely powerful tool for early diagnosis of cancer and effective means to improve personalized based drug treatment decision making.