Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Regional Translation of Excellence into Medical Innovations for Delayed Aging (ARTEMIDA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Germany,Sweden,Slovenia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-05-07
End date: 2020-05-06
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 3
Project status: CLOSED

Our vision is to become by 2020 a Central and South-East European (CSEE) Centre of Excellence for Translational Medicine (CETM), coordinated by the Faculty of Medicine, University of Ljubljana that will harness, develop, exploit and market the significant potential for research and innovation in the region. The vision of CETM is to form the hub of an alliance of biomedical and health-related research and innovation institutions from CSEE. This long-term science and innovation strategy will be achieved by establishing a partnership between leading scientific institutions the Karolinska Institutet and the European Bioinformatics Institute on the one hand and the Consortium of teaching, research and health institutions and SMEs from Slovenia with partners from other low performing regions of CSEE on the other hand. Specifically, under the mentorship of these leading scientific institutions, the proposed CSEE CETM will upgrade, integrate, exploit and market the regions research and innovation potential in the field of aging with special reference to neurodegenerative diseases, diabetes and cancer in Slovenia, with partners from Albania, Bosnia and Hercegovina, Bulgaria, Croatia, Czech Republic, Greece, Hungary, NE Italy, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, Slovak Republic and European part of Turkey (population of about 100 million). The proposed CETM has the potential and ambition to use the Teaming seed money to stimulate inter- and intra-regional networking of research and innovation clusters thus promoting collaboration on large-scale research and innovation grant applications or clinical studies in the field of translational medicine. The vision of the CETM includes: 1. Spreading innovation-focused, research culture in CSEE and developing marketable products and services; 2. Developing a properly functioning, accountable, transparent, service-oriented CETM administration in accordance with relevant ISO standards for customers’ satisfaction.

Keywords: translational medicine,healthy aging,innovation,diabetes,cancer,neurodegenerative disease,data management,bioinformatics,personalised medicine
Advanced platform for profiling of therapeutic targets and functional analysis of circulating tumour cells in cancer patients (CTCapture_2.0)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 149825.0
EU funding (EUR): 149825.0
Participants: 1
Project status: CLOSED

As an alternative to invasive needle biopsies, the analysis of CTCs released by metastatic lesions into the blood has been recently introduced by the PI as “liquid biopsy”. The molecular analysis of CTCs before and during treatment could supply a real-time status of the landscape of metastatic tumor cell clones in an individual cancer patient. CTCs might reveal representative information on metastatic cells located at different sites because the blood represents a pool of tumor cells potentially released by all lesions in the cancer patients. Moreover, blood samples can be taken sequentially during the course of the disease and therefore allow a real-time assessment of the molecular evolution of the disease with important implications for decision making on cancer therapies. However, despite the obvious potential of CTCs as biomarker, current CTC capture assays require sophisticated, expensive and complex assay systems, which is the most important bottleneck for a more widespread use of CTCs as liquid biopsy. The assay development in the ERC PoC Grant CAPTURE-CTC (end: 11/2016) and the successful research on improved methods for molecular characterization of CTCs in the Advanced Investigator Grant DISSECT (end: 07/2016) of the PI has allowed to develop a novel improved platform for CTC detection. To implement our chip into future clinical decision making, we will now focus on the clinical validation of the chip platform including the development of SOPs as basis for kits for expression of therapeutic targets and resistance mechanisms in CTCs. Moreover, the establishment of transient CTC cultures from chip-isolated tumor cells will foster drug testing in individual cancer patients. In conclusion, the CTCapture_2.0 project will be an important prerequisite for successful future commercialization of a novel liquid biopsy assay.

Keywords: nanotechnology,microfluidic chips,cancer,circulating tumor cells,blood,liquid biopsy,precision medicine,oncology
EXTRACTING VALUE FROM BYPRODUCTS OF THE FOOD INDUSTRY (BPV)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year, nearly 360 million pigs, sheep, goats and cattle as well as several billion poultry are killed in EU slaughterhouses according to the FAO. Processing feedstock produces large amounts of animal waste and wastewaters, more than 16 million tons each year in Europe. These waste are a key challenge as they cannot be treated as standard waste due to banning legislation and technical issues. Anaerobic Digestion is considered an interesting alternative for waste management and animal byproducts (ABP) are seen as an excellent substrate due to a high content of lipids and proteins However, although the use of ABP to produce biogas represents a great opportunity for animal processors and biogas plant operators, there are limitations to its development: BPV is interesting from an industrial point of view because it reduces the number of steps of the waste processing and save energy (by 40%), is more efficient for biogas production than classic waste (28%), easy to implement and can be made serially at industrial premises. In the EU, biogas is a renewable biofuel, which does not contribute to climate change and can substitute to fossil fuels for production of heat and power. Combined with ABP, it contributes to solve the challenge of difficult to process waste.

Keywords: animal byproduct,anaerobic digestion,biogas,waste to energy
MANUBACK, the smart garment for operator protection in the field of Manual Handling of Goods (Manuback)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Bulgaria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

DYNABACK delivers wearable technology supporting a healthy lifestyle in everyday life. At the core, a functional garment with an array of inertial sensors. The garment connects with your Smartphone and a cloud service delivering real-time and long term insights about how you move. The garment is developed with sustainable materials and comfort to be worn throughout the day as an undergarment or by itself. This project aims at deploying the Dynaback garment for Work and Safety in the field of Manual Handling of Goods. A feasibility study will be conducted in order to validate the solution and to further test its accuracy. Furthermore, the project will serve to assess the market viability of the Dynaback product, and to determine the best strategy to market.

Keywords: wearable
Democracy, Anger & Elite Responses (DANGER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1498932.0
EU funding (EUR): 1498932.0
Participants: 1
Project status: SIGNED

This project is about the elite coalition strategies that will avoid democratic failure and deconsolidation – the loss of legitimacy among its elites and citizens. It will answer the question of which government coalitions help to avoid democratic deconsolidation, and ultimately democratic breakdown. It will do so by investigating the fate of democracies in interwar Europe, the best available comparison cases for contemporary democracies, and derive precise recommendations for policy-makers today. Presently, democracy is under threat around the world. Citizens disenchanted by economic inequality and migration are losing faith in democratic regimes. Populist parties and extremists at both ends of the political spectrum threaten democratic actors, institutions, and norms throughout the Western world. Yet few if any democracies today have failed outright, and this project adopts a historical-comparative approach and investigates the fate of 24 interwar democracies in Europe. The project makes five central contributions that move it beyond the current state of the art in political science. First, it innovates conceptually by investigating democratic deconsolidation, the loss of legitimacy among democracy’s elites and citizens, and democratic survival. Second, it innovates theoretically by developing a theory of strategic interdependencies between prodemocracy and antidemocracy political actors against the backdrop of citizen anger. Third, it innovates empirically by collecting new data on government coalitions and elite power grabs as well as citizen protests and political violence events. Fourth, it innovates methodologically by combining the strengths of quantitative, qualitative, and causal inference methods to investigate the effect of coalition governments with and without antidemocracy elites on democratic deconsolidation. Fifth, it innovates in terms of impact by matching historical to contemporary cases to derive lessons for today’s decision-makers.

Keywords: democratic deconsolidation,democratic survival,government coalitions,political violence
Elucidating how XRN1-mediated RNA degradation controls virus infection (RNAdeg-Virus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Commandeering the cellular gene expression machinery is essential for viruses in order to replicate their genome and ensure the production of their progeny. One of the major events occurring during viral infection is the virus-induced host mRNA degradation, process orchestrated by the exonuclease XRN1. However, the exact role of this enzyme remains controversial and largely elusive. An exciting stepping stone for studying XRN1 involvement in virus infection is the observation that human cells depleted of this protein are refractory to the infection of sindbis (SINV), a mosquito-borne virus. This suggests that this exonuclease is essential for SINV infection. It has been shown that the cellular RNA is massively degraded upon infection and that RNA degradation is the main force shaping the host transcriptome. Thus, I propose to identify the cellular and viral RNAs directly bound to and regulated by XRN1, using cutting-edge system-wide approaches, which will shed light on the targetome of this protein. Moreover, I plan to study how XRN1 is triggered, for instance by virus-induced posttranslational modifications or by differential protein complex assembly using mass-spectrometry analysis. Discovering the molecular events that activate XRN1 will be fundamental for determining its precise molecular mechanism of action and why it is important for viral infection. Additionally, the outcomes of this multidisciplinary approach will be beneficial for studying gene expression and RNA degradation-related processes, such as cancer. This innovative project will generate a vast amount of valuable data, which will allow to dissect the infection mechanisms of a mosquito-borne virus, leading to the identification of potential targets for antiviral drugs, with a consequent strong medical and socio-economic impact.
Metallurgical Traditions in West Africa: Technology, Production, and Exchange of Iron and Copper in Nigeria from 700 BC to AD 1800 (METALS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-09-01
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 1
Project status: SIGNED

METALS aims to explore the Metallurgical Traditions in West Africa with emphasis on the Technology, Production, and Exchange of Copper in Nigeria from 700 BC to AD 1800. This period is significant in Nigeria’s past due to evidence of intense metalworking traditions with emergence of social complexity. There are two questions central to this project: first, what was the evolution of metallurgical traditions in early Nigeria in relation to technical processes and development and raw material choices? Second, how did prehistoric craftspeople in Nigeria interact with the wider region in terms of navigating production and consumption of copper and its alloys through the social network system? METALS will prioritize copper metallurgy as the more elusive technology, but will consider iron metallurgy equally alongside the copper research, not least to lay the foundation for a follow-on project proposal targeting Nigeria’s early iron metallurgy. The project will select materials from collections of museums both in Nigeria and Europe, while training-through-research will take place on an existing assemblage at the Host institute from a site in Morocco for an in-depth study on metallurgical production and development. The Nigerian museum assemblages will be complemented by materials from targeted archaeological fieldwork at areas of prime potential in southern Nigeria. Optical microscopy, handheld X-ray Fluorescence, SEM-EDS, and lead isotope analysis will be used to reconstruct the mineralogical and compositional constituent the metal and the chaîne opératoire of their production. METALS is designed as an interdisciplinary project that integrate material science, archaeology, anthropology, geochemistry, museum studies, anthropological theory and African/global history. This project will significantly expand knowledge of Africa’s contributions to metallurgy in global perspectives, and construct an open access online database of elemental composition of early metal objects.

Keywords: archaeometallurgy,copper alloy,nigeria,technology,production,exchange,trade,west african,benin bronze,lead isotope analysis,copper mine,african iron age,museums collections
incPRINT as a platform for RNA-targeted drug discovery (incPRINT-DRUG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

RNA transcripts have emerged as key regulators of diverse biological phenomena and are implicated in many human diseases including neurodegenerative disorders, cancers, viral infections and antibiotic resistance. As such, RNA represents an untapped source of therapeutic targets. Bioavailable small molecules have been recently successfully applied to target RNA. One caveat, however, is that lead compounds are not easily designed from RNA sequence or structure and therefore targeting RNA by small molecules remains challenging. One of the strategies to target RNA with small molecules is to target RNA-protein interactions or RNA elements stabilized by protein binding. However, the unbiased in vivo identification of small molecules that selectively target RNA-protein interactions with little cellular toxicity remains unachieved due to the lack of technology. In the incPRINT-DRUG project, we will adapt our innovative high-throughput RNA-protein interaction technology for unbiased identification of small molecules that target specific pathogenic RNA-protein interactions. Our unique technology enables drug testing in living cells combined with the simultaneous testing of drug specificity and toxicity. Our core technology has been extensively validated over the past years and proved to be robust to be optimized and adapted for the RNA drug discovery. Our business development strategies will follow several possible scenarios: (1) license the technology, (2) generate new IP with the technology and license the IP to industrial partners, (3) industrial partnership by providing service to biotech and pharma companies. All three options will be explored with our Technology Transfer & Industrial Partnership Office. incPRINT-DRUG is expected to have a strong biomedical and economic impact given the growing interest in finding small molecules targeting pathogenic RNAs and the technological gap to achieve it using data-driven experimental methods.

Keywords: pathogenic rnas,toxic rnas,rna drug discovery,small molecule inhibitors,incprint,rna protein interactions,biotechnology
Children and Transnational Popular Print, 1700-1900 (CaTPoP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-30
End date: 2021-09-29
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Both popular and children’s literature have increasingly been understood as important elements of the pre-modern history of print. Exciting research is being undertaken in both fields. Yet systematic research on the crossover between these two forms of cultural production has not been undertaken. The extent, diversity and significance of children’s popular print remains largely unknown. CaTPoP will be the first project to methodically examine European children’s popular print, 1700-1900. An ambitious programme of fieldwork will provide the first overview of cheap, ephemeral print that was either produced specifically for children and young people, or that was used predominantly by them. The aim is to establish the extent to which popular print reached young people, and to give a full account of the different forms that were produced with children as a target audience. These will include educational books (eg. ABCs, almanacs, catechisms...), and more imaginative, and attractively illustrated works, including penny prints, ballads, chapbooks and romances. Despite linguistic, cultural and confessional differences, it is clear that some formats and titles appeared across Europe, and CaTPoP will take a transnational approach, tracing geographical (and temporal) continuities, and fractures. The aim is to assess whether a shared print culture existed for children across Europe. CaTPoP will not only advance scholarly understandings (print history; children’s literature), but will support the curation of cultural heritage. Secondments in different countries and sectors (a museum, a library, a university) will raise awareness and expertise among professionals, and support the communication of findings to a general audience, both online and through events and a touring exhibition. CaTPoP will enhance the principal researcher’s skills, as well as the host venues’ capabilities. It aims to recover a significant part of print culture that has been for too long overlooked.

Keywords: children s literature and culture
Cortical Microcircuits: Parvalbumin neurons Orchestrate Stress Eating (CoMPOSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Stress leads to enhanced food intake and a shift in dietary choices towards more high-caloric and unhealthy food. While this serves an adaptive purpose to replenish energy stores after a physical challenge, in modern society where continuous psychological stressors are present and cheap unhealthy food easily accessible, this leads to an alarming situation where many people overeat. As a consequence, obesity levels are rising with severe consequences for our health. Especially people with an eating disorder, like binge-eating disorder, are vulnerable to this situation. Human and animal studies both point to a critical role of the prefrontal cortex (PFC) in coordinating stress-induced food intake. The prefrontal cortex is a highly heterogenous structure sending coordinated neuronal output to many brain regions with opposing roles in food regulation. This indicates that these circuits are under tight regulation of local interneurons. However how interneurons coordinate circuits for stress-induced feeding behavior is not known. In this project I aim to understand how Inhibitory interneurons shape output patterns of prefrontal cortical pyramidal neurons in a projection-specific manner to drive stress-induced food intake. To this aim I will use a combination of viral tracing techniques and in vivo electrophysiological recordings of identified PFC interneurons and pyramidal neurons in mice. Moreover I will use chemogenetic approaches to manipulate specific PFC pyramidal neural circuits to understand their role in stress eating responses. This will yield important insight into the circuit mechanisms underlying this maladaptive behavior. Studying how this phenomenon arises at the level of neuronal circuits will provide evidence-based targets for prevention strategies.

Keywords: cortical circuits,prefrontal cortex,parvalbumin interneurons,pyramidal neurons,stress,feeding,in vivo electrophysiology,chemogenetics