Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Science in Motion for Friday Night Commotion 2020 (SCIMFONICOM 2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-07-01
End date: 2021-01-31
Duration (months): 7.0
Total project cost (EUR): 108012.5
EU funding (EUR): 108012.5
Participants: 2
Project status: CLOSED

SCIMFONICOM 2020 is a seven-month organized by the Faculty of Physical Chemistry and Institute of Molecular Genetics and Genetic Engineering, University of Belgrade. Within this project, Researchers’ Night event will be organized around the theme "Lighten up your mind" in 12 cities and 3 rural communities in Serbia. The project is supported by prominent educational institutions such as Serbian Academy of Sciences and Arts and Regional Centre for Talents. The program planned to be organized on September 25 and 26, 2020 is envisaged to include a range of highly interesting and stimulating activities, from Power up the World (series of interactive demonstrations in the area of physical sciences); Power of life (series of interactive demonstrations in the area of life sciences); Power of mind (series of interactive demonstrations and workshops in the area of social sciences); Treasure Hunt (win an award by completing hands-on experiments); Science Up (short lectures and demonstrations regarding the scientific principles behind the things we use in our daily lives); Open Lab (visit to a research laboratory with opportunity to see researchers in action); Around the World in 60 days (interactive digital media workshop) and 10 most exciting scientific experiments (interactive lectures); European Corners (interactive display of EU projects in Serbia and trivia game challenging visitors knowledge) to Science Vans (mobile researchers’ teams in rural areas). SCIMFONICOM 2020 is expected to continue contributing to the raising of public awareness about research (both in the area of natural and social sciences) and to bring researchers closer to the visitors by offering new activities and locations while obtaining greater support of educational institutions and other organizations towards RN main ideas. The project will take part in the regional RN network, bringing greater synergy at the regional and European level and emphasizing European character of RN.

Keywords: renewable energy,great science adventure,treasure hunt,science vans
Patterns of land-use and human mobility in a time of climate changes (Italy, 6th to 10th cc.) (InAndAround)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-15
End date: 2024-08-14
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

The period from the sixth- to eleventh- century in Italy is one of the most profound political and social laboratories in European history. Centered on this region and period, the primary goal of the In&Around project is to chart the effects of climate change on human behaviour. By focusing on early and high medieval Italy, the project aims at exploring the interaction between climate variability and human agency with a lens towards management of the environment and in the light of shifting political regimes, while capturing details on past issues of contemporary significance like human mobility and workforce relocation. Within the area of Italy, two micro-regions with distinct medieval histories are targeted for specific investigation: Lucca and Rieti. The project will generate new long-duration and high-resolution climate records from recently cored lake sediments combined with data derived from written sources and already extant climate reconstructions. By way of its innovation-through-interdisciplinary approach, the project will offer important opportunities for expanding the applicant’s expertise through integrating different kind of datasets, while contributing enormously to an expanding field of study in i) determining how data drawn from historical archives, natural proxies and modelling may inform respectively one another; ii) filling in a gap in research both chronologically (the first millennium of the Common Era) and geographically (the Italian peninsula) and iii) producing two new research tools useful for future studies, i.e. a repertory of 'reclaimed lands' and climatic extremes and a statistical model for climate reconstructions. Through its foci on the human responses to climate and environmental change, the project responds directly to the Horizon 2020 Work Programme to understand “the causes of climate change and to pave the way for pathways and solutions to address them”.

Keywords: middle ages,medieval climate anomaly,land use,workforce mobility,italy
The gut microbiota and its systemic effects on metabolism and atherosclerotic disease (GUTSY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Atherosclerosis is the main pathological mechanism causing myocardial infarction and ischemic stroke. Evidence has mounted about the association between the gut microbiota and cardiovascular disease, but whether the associations are causal is largely unknown. For optimal prevention and treatment of cardiovascular disease, there is an urgent need to determine whether there are any true effects that might be targeted by interventions. The overall goal of this project is to assess causality between gut microbiota and atherosclerotic disease and to provide easily accessible biomarkers for an atherosclerosis-enhancing gut microbiota. To this end, the research program has three main objectives: 1.) Identification of gut microbiota characteristics associated with atherosclerosis measured by coronary computed tomography angiography and high-resolution carotid ultrasound in a population-based sample of 10,000 individuals and through prospective follow-up for myocardial infarction and ischemic stroke. The microbiota will be characterized by next-generation sequencing techniques in faecal samples. 2.) Identification of plasma biomarkers associated with an atherosclerosis- enhancing microbiota using comprehensive metabolomics profiling of 800 named metabolites in plasma from 800 individuals with replication in additional 800 individuals 3.) Clarification of the causal effects of gut microbiota characteristics on atherosclerosis, myocardial infarction and stroke by development of novel genetic instruments and applying Mendelian Randomization analysis I have access to unique study materials and documented experience of successful projects using large scale -omics data and state-of-the-art epidemiological methodologies. My project is expected to lead to the identification of characteristics of an atherosclerosis-enhancing gut microbiota and associated plasma biomarkers that may open up new avenues for effective prevention of atherosclerotic disease.

Keywords: atherosclerosis,mendelian randomization,microbiome
Controlling Wavefunction Overlap for Triplet Energy Transfer in Organic/Nanocrystal Quantum Dots Hybrids (TRITON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The generation, control and transfer of triplet excitons in molecular and hybrid systems is of great interest for optoelectronic applications such as light emission, singlet fission, up/down-conversion and photovoltaics. While coupling triplet excitons from inorganic QDs to organic molecules has been well demonstrated, the reverse process, the transfer of triplets from organic semiconductors to QDs is much more challenging and the underlying reasons are still unclear to the field. Recently, the host group has demonstrated that it is possible to transfer triplet excitons from molecular acenes to emissive nanocrystal quantum dots (QDs). This allows the direct conversion of dark triplet excitons to photons in the hybrids. As triplets generation yield through singlet fission in acene molecules can be up to 200%, this discovery opens a new avenue for highly efficient down-conversion. However, the exact factors that govern the transfer, especially the role of interfaces between the two components, remains unknown. The project will build on the host group’s discovery to develop the fundamental science of this new hybrids platform for optoelectronics. Specifically, we will develop a series of highly controlled solution/solid phase systems, where the interfacial conditions of the hybrid will be intentionally modified. The surface ligands, passivation, energy states of the QDs and the distance to the molecules will be precisely controlled. The molecules will also be covalently attached to the QD surface by a range of functional groups. These systems will be studied with steady-state and time-resolved spectroscopies with the aim of elucidating the underlying mechanism controlling the wavefunction overlap and triplet exciton transfer in the hybrids. We will also conduct proof of concept experiments to demonstrate the use of the optimised hybrid materials for down-convertor. These fundamental investigations will open up new possibilities for down-conversion and optoelectronics.

Keywords: organic semiconductors,nanoparticles,quantum dots,energy transfer,surface chemistry,spectroscopy,photon management,down conversion
Nano-tailoring organo-mineral materials - Controlling strength and healing with organic molecules in mineral interfaces (NanoHeal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Israel,Norway,Norway,France,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 4103572.68
EU funding (EUR): 3817297.44
Participants: 8
Project status: CLOSED

Cement production for the construction industry contributes up to 5% of anthropogenic CO2 emissions. Developing more environmentally friendly concrete requires the assessment of strength for a diverse range of new cement materials. Similar issues arise during the development of biocompatible cements for medical applications. Properties of naturally cemented materials of organic origin are of key importance in the oil industry, with carbonate reservoirs prone to creep, particularly during the injection of CO2 for enhanced oil recovery or permanent storage. However, despite the importance of cement materials to our infrastructure, health and environment, we still lack the fundamental basis for understanding the strength of cemented aggregates. Granular pastes and sediments transform to strong solids through reactions at nano-confined mineral interfaces, where nucleation and growth at the adjacent solid surfaces are affected in a manner not yet understood. There is a need for improved concepts, theories and models. NanoHeal targets this issue by bringing six industrial and six academic groups together in a European Training Network (ETN), in an emerging interdisciplinary field spanning from basic sciences to the corresponding engineering disciplines. NanoHeal will deliver an outstanding environment for training and career development of young researchers. The aims of NanoHeal are to: • develop innovative probes and models for nanoscale processes that open novel perspectives in design and control of organo-mineral materials. • measure and improve the strength and durability of 1) new man-made cemented materials like “green concrete”, speciality cements in construction and oil and gas recovery, and biocompatible implants and 2) natural sedimentary rocks inside reservoirs and as construction materials • educate young interdisciplinary researchers at the interface between fundamental science and European industry.

Keywords: cement,carbonate rock,deformation,strength,organic,mineral composite
TOWARDS AN ENHANCED ACCIDENT MANAGEMENT OF THE HYDROGEN/CO COMBUSTION RISK (AMHYCO)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Ukraine,Slovenia,France,France,France,Netherlands,Canada
Call: Safety assessments for Long Term Operation (LTO) upgrades of Generation II and III reactors (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4071051.25
EU funding (EUR): 3974402.5
Participants: 13
Project status: SIGNED

Combustible gases are one of the few elements that can really challenge the containment integrity. An appropriate management of the associated risk is paramount to avoid the potential release of large amounts of radioactive material to the environment. Surprisingly, the Severe Accident Management Guidelines (SAMGs) have not been updated according to the knowledge gained in the last decade and the database extension resulting from recent and ongoing projects. The AMHYCO project intends to respond to practical questions, such as the right timing and mode for actuation of containment safety systems (i.e., FCVS, sprays, fan coolers) to reduce as much as feasible the threat posed to containment integrity. To do so, all the available tools to enhance the present status (i.e., LP, 3D and CFD codes, together with experimentation and the best use of engineering judgement) are to be applied. Three specific objectives are set: • To improve the Severe Accident Management Guidelines (SAMGs) for both in-vessel and ex-vessel phases with respect to combustible gases risk management, using both numerical and experimental results. • To investigate experimentally phenomena that are difficult to predict numerically: H2/CO/H2O distribution and combustion and PARs behavior under realistic accidental conditions, taking into account the safety systems interaction. • To improve the predictability of the numerical tools - Lumped Parameter (LP), 3D containment and Computational Fluid Dynamic (CFD) codes - used for explosion hazard evaluation inside the reactor containment to gain relevance in supporting SAMGs design and development. The scope of this project is outlined by the most common reactor technology in the EU: PWRs. The whole project is structured in 7 WPs (coordination included) in which an entire WP is to be devoted to the enhancement of SAMGs. Finally, AMHYCO has received the NUGENIA label and 9 organizations have shown their interest with support letters .

Keywords: samgs,combustion risk,co combustion,par efficiency,fcvs,ex vessel phase,containment,severe accident
Repair of Junctional Atrioventricular Conduction and Impulse Formation (REJUVENATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: CLOSED

Background: To bypass hardware-related complication there have been substantial efforts to create biological pacemakers. Effective strategies have been identified and are now being refined for delivery of long-term function and clinical application. Yet, currently developed biological pacemakers only provide pacing to atrium or ventricle thereby aiming at ~20% of pacemaker patients. To unleash the full potential of biological pacing, targeting virtually every pacemaker patient, effective repair of atrio-ventricular (AV) conduction is crucial. With the arrival of advanced stem cell-based therapies, now is the time to meet this important challenge. Objective: To develop a stem cell-based therapy that restores impulse formation and conduction at the interface between atrium and ventricle. Approach: Human induced pluripotent stem cells (hiPSCs) will be used to produce cells with hallmark features of AV nodal cells. After in vitro testing, these cells will be implanted in vivo (together with biomaterials) to form AV bypass tracts in sheep that are in permanent AV block. In this setting, approaches will be tested for their ability to bridge electrical activity from the atrium to ventricle and protect the ventricle from atrial tachycardia. The final steps of this project focuses on the development of dedicated implantation catheters (in collaboration with Medtronic) and optimization of cellular constructs that are regulatory compliant and ready for clinical testing. Impact: By developing novel therapies to re-establish AV impulse formation and conduction I will broaden the application area of biological pacing to nearly all patients. In Europe ~300.000 pacemakers are implanted annually representing cots of ~8 billion Euros. Five per cent of these implantations result in serious complications requiring re-implantation or other invasive treatments. Biological pacemakers are expected to reduce these complications, improve quality of life, and reduce healthcare costs.

Keywords: cardiac arrhythmias,biological pacing,av node regeneration
Lubrication system by oil mist (LUBRICAIRLESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of the project is to introduce and sell an innovative technology for the lubrication of industrial machinery on the global market. This technology consists of a new lubrication system by means of oil mist. Compared with existing systems (Venturi and Vortex), it is much more efficient (90% reduction of energy consumption while in operation), more respectful of the environment (based on an analysis of the life cycle) and may also be used in systems that require high viscosity lubrication oils, thus replacing high energy-consuming technology.

Keywords: ecoinnovation,energy,efficient,lubrication,mist
High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid (Hi-SynVir)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment. Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations. We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays. The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new ecology, assess its potential for future evolution and inform the safe use of viral vectors for the targeted biocontrol of insect populations.