Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating structures and functions in the arachnoid barrier (Arrachnobarrier2.0)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Less is known about the structural and functional importance of the arachnoid barrier than any other CNS barrier, including the blood-brain barrier. Animal models of arachnoid barrier impairment are not known/have not been analyzed. The sophisticated architecture and cellular specialization of the arachnoid barrier includes tight- and tricellular junctions joining two cell layers, direct contact with other arachnoid cells, and the specific expression of a broad repertoire of influx and efflux transporters, suggest major importance. Lack of understanding of the arachnoid barrier represents a conspicuous knowledge void in neurobiology. The Arrachnobarrier2.0 project seeks to elucidate and understand these features and to examine their pathophysiological importance. We will test the hypothesis that arachnoid barrier disruption may have serious consequences for CNS function. We will also test the hypothesis that the arachnoid barrier is responsive to diverse disease conditions and can contribute to disease pathophysiology. We hypothesize that the arachnoid barrier has regional cellular and molecular adaptations that underlie CSF transit from the subarachnoid space to dural lymphatics. Some of these sites are known, such as olfactory nerve and cranial nerve exit sites, whereas others are more speculative, such as arachnoid granulations and sites of bridging vein crossing. The three Specific Aims in this proposal will address these aspects of arachnoid barrier structure, function, molecular and regional heterogeneity, and pathophysiology. This proposal is innovative and has potential for ground-breaking discovery because arachnoid structure and function has remained elusive since its anatomic description ≈500 years ago and the discovery of its barrier properties ≈50 years ago. The project offers unique insights into the cellular and molecular composition of the arachnoid, its physiological function, regenerative capacity and pathophysiological roles.

Keywords: meninges,arachnoid mater,arachnoid barrier,single cell rna sequencing,fibroblasts,cell junctions,traumatic brain injury,leptomeningeal metastasis
Precise optical synchronization of high-speed electronics with microcombs (ProSync)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 3499696.0
EU funding (EUR): 3499696.0
Participants: 1
Project status: SIGNED

Laser frequency combs based on mode-locked lasers are extraordinary photonic devices that have revolutionized precision frequency synthesis and metrology in the 21st century. They have enabled groundbreaking developments such as optical clocks, femtosecond-level timing synchronization, and ultra-pure microwave generation. Microresonator-based frequency combs (microcombs) offer a transformative potential to reduce the complexity and size of traditional laser frequency combs. Recent advances in dissipative Kerr solitons have demonstrated the viability of these chip-scale devices, which can be manufactured at the wafer level through semiconductor processing techniques. However, microcombs still fall short in stability and phase noise compared to their non-integrated, mode-locked counterparts due to intrinsic scaling limitations when operating at the chip scale. This proposal seeks to bridge this performance gap by developing high-performance, octave-spanning microcombs with photodetectable repetition rates using innovative arrangements of coupled microresonators. These advancements will enable single-point optical frequency division, whereby the comb’s degrees of freedom will be determined by an optical frequency reference. The project will explore 3D integration of ultralow-loss silicon nitride with advanced materials, aiming to create high-performance microcomb-based systems on a chip, and lay the foundation for novel optoelectronic synchronization architectures in datacenters. These innovations address key challenges in energy consumption and capacity scaling in datacenters and large scaling computing architectures, paving the way for future advancements in global communication infrastructure.

Keywords: silicon photonics laser frequency combs fiber optic communications microresonator frequency combs
Port Arrivals Data. Automatic data collection for a large-scale comparative history of 19th century shipping: a Digital Humanities approach to maritime heritage (PortADa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Greece,Cuba,Argentina
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 644000.0
EU funding (EUR): 644000.0
Participants: 10
Project status: SIGNED

In the nineteenth century, during the transition from sail to steam, port cities were nuclei of imperial colonialism and capitalist configurations, linked by maritime trade and traffic to the processes of globalisation and the international division of labour. In these ports, the arrival of ships represented an economic, cultural, and political event. At the local level, complex port systems were created, also based on local, regional and fluvial trade and traffic. As such, the news of the arrival of ships received a place of privilege in the local press of these port cities. This project is based on the daily notices published in the majority of important port cities, and that contained information about the arrival of ships in the port. This was very complete and detailed information that, in general, included: the port of embarkment, ports of call, and days travelled; the type, name, and tonnage of the vessel; the name of the person responsible for the vessel (captain or skipper) and the flag flown; and, the cargo and the name of the business owner to whom it was to be delivered. This is a source of information that has been used in a variety of studies dedicated to maritime or economic history. However, because of the great effort required to exploit the source, these studies have always been rather partial: limited to short chronologies; focusing on a single type of cargo; or centred on a determined route. As such, in this project, we will take advantage of the opportunities offered to us by changes in the technological landscape over recent years – mainly the availability of extensive collections of digitalised historical newspapers and the ongoing development of software tools that facilitate bulk exploitation of these valuable resources. This allows us to automatically create databases of maritime traffic from 1850s to 1910s in the ports of Barcelona, Marseille, Buenos Aires and Havana, composed of thousands of records.

Keywords: museums and exhibitions
Structural and molecular basis for transcription-replication collisions (ReTraCol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

One of the sources of genome instability is the occurrence of transcription-replication collisions (TRCs). These collisions occur when the replication machinery collides with the transcription complex due to the presence of obstacles in the DNA template, such as DNA-bound proteins or structures known as R-loops, which are three-stranded nucleic acid structures that inhibit the normal progression of both systems. These R-loops are often formed during transcription, but their assembly is regulated by several cellular mechanisms that prevent the accumulation of TRCs. TRCs can potentially cause deletions, chromosomal rearrangements, and loss of genetic information due to DNA double-strand breaks generated by the collision. High levels of TRCs have been found in several types of cancer, which is a growing global health concern. Although many studies have investigated the role of TRCs in normal and cancer cells, the detailed molecular mechanism behind TRCs remains to be elucidated. The ReTraCol project aims to bring together the fields of transcription and replication to gain a deeper molecular and structural understanding of R-loop-dependent TRCs using biochemical and cryo-EM techniques. The expected results will reveal how the replication and transcription systems behave during a collision and describe the stepwise formation of TRCs. This project could lead to an understanding of the impact of TRCs in both normal and cancer cells, and potentially open new future investigations to use TRCs as a cancer target.

Keywords: replication,transcription,rnapii,r loops,cryo em
reuSable strAtegic space Launcher Technologies & Operations (SALTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Portugal,Italy,Spain,Romania,Ireland,Belgium,Poland,Latvia,Czechia,Sweden
Call: Reusability for European strategic space launchers - technologies and operation maturation including flight test demonstration (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2022-12-01
End date: 2026-01-31
Duration (months): 38.0
Total project cost (EUR): 42502363.5
EU funding (EUR): 39000000.0
Participants: 28
Project status: SIGNED

SALTO will perform, for the first time in Europe, fly / recover / refly cycles of a reusable rocket first stage demonstrator. Operating a large-scale vehicle at low altitude, consistent with future European strategic needs, and embedding a set of critical technologies, the project will significantly boost the strategic launchers roadmap, enabling the vision of a future launch fleet improving by 50% space access costs and reducing environmental impacts. SALTO will hence act as a “stepping stone” towards reusability of strategic launchers in Europe which is one of the key leverages to reach such vision. Fully aligned with previous ESA-funded activities (e.g. Themis initial phase Program), SALTO focuses on - Technologies and building blocks maturation up to TRL5/6 for the first stage of a strategic launcher; - Subsystem/system tests with two low altitude system tests (“hop test”) campaigns. SALTO's methodology will combine robust system engineering with technology maturation activities and a stepped demonstration strategy to accelerate experimental learning through the implementation of the Agile methodology. The SALTO project will culminate in flight test campaigns to demonstrate and validate the technologies necessary for a reusable launch vehicle. SALTO will contribute to the cost reduction target for strategic launcher in Europe by addressing ~3/4 (in cost) of all technologies / operations involved in a future European reusable rocket stage. While Europe is currently lagging behind other global players when it comes to reusable launchers, SALTO will reinforce EU’s independent capacity to access space, secure autonomy of supply for critical technologies and equipment, and foster EU's space sector competitiveness. At the end of the project, lessons will be drawn regarding the maturity of the different technological bricks, TRL and readiness for flight tests. A roadmap to increase their maturity will be prepared in view of suborbital tests by 2025.

Keywords: reusability,strategic launcher,technology maturation,low altitude flight test,gnc,avionics,health monitoring and safety aerodynamic,landing system,launch vehicle,ground segment,propulsion
Large-Volume Electron Spectroscopy for Neutrino Mass Measurement (NuMass)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 1
Project status: SIGNED

Neutrinos, assumed massless in the Standard Model of particle physics, must have masses to explain the observation of neutrino oscillations. However, the absolute neutrino mass scale remains elusive. Laboratory measurements using tritium beta decay provide the most direct and model-independent means of determining neutrino mass. Yet, current experiments utilizing molecular tritium sources face fundamental sensitivity limits. This project aims to develop a groundbreaking resonant cavity detector capable of performing neutrino mass measurements with unprecedented precision. Within this project, I will develop and build a resonant cavity, laying the foundations for the next-generation neutrino mass measurement. The detector will simultaneously serve as a high- volume trap for neutral atomic tritium and as a detector for beta decay electrons. Utilizing cyclotron radiation emission spectroscopy (CRES) in a cubic-meter-scale cavity, this technique promises to significantly enhance sensitivity by resonantly amplifying the power of emitted radiation from trapped electrons, which has never been demonstrated. This will increase the CRES-sensitive volume by five orders of magnitude and reduce the power threshold for signal detection by four orders of magnitude, enabling high-precision measurements that could decisively determine the neutrino mass scale. Beyond its critical role in advancing neutrino physics, this project will contribute innovative tools and methodologies to the ultracold atom community and other precision measurement fields. By overcoming existing technological barriers, this detector paves the way for revolutionary advancements in our understanding of fundamental particles.

Keywords: neutrino mass,neutrino properties,detector development
Conserving Forests through Indigenous Heritage: The UNESCO World Heritage Cultural Landscape, Alternative Sovereignty and Semai Life Projects in Peninsular Malaysia’s Last Surviving Rainforests (SERAAQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 226276.8
EU funding (EUR): 226276.8
Participants: 1
Project status: SIGNED

Seraaq, the project acronym, means ‘forest’ in the Indigenous Semai language, connoting the sentience and sacredness of forests, and the moral calling to forest stewardship. The project highlights the importance of Semai (agri)cultural heritage in forest conservation, and the need for a blueprint to achieve, at minimum, alternative sovereignty: could the UNESCO World Heritage Cultural Landscape serve as a tool of empowerment for the minority Semai people of Peninsular Malaysia? SERAAQ’s originality lies in linking cultural heritage protection to securing Indigenous rights to forests and resources, and by identifying ways to support Indigenous forest livelihoods as a purposeful community development option within and in spite of prohibitory state structures. SERAAQ also demonstrates that Indigenous heritage resources are real, functioning parts of Indigenous social-ecological systems rather than free-standing, unidimensional cultural heritage elements. I will assess the potentialities of the WHCL mechanism, and gather documentation of contemporary Semai forest reliance and ‘living’ heritage, by using political economy analyses and field-based survey, PhotoVoice and scenarios planning approaches. This will produce quantifiable, evidence-based data, to persuade and effect change at the decision-making/governance levels. This evidence will take into account Semai articulations of their own self-determined ‘life projects’ or forest-based futures, ideas of forest protection and community empowerment outcomes, e.g, inclusion in forest governance processes; public recognition of the Semai homeland; and legal rights to their customary forestland. An MSCA fellowship will help me innovate my oral tradition research background, to work expertly on political/socioeconomic topics in the heritage and forest conservation fields, especially in regard to the exigencies of Indigenous poverty and disadvantage.

Keywords: indigenous peoples,forests,development as freedom,justice,cultural landscapes,tangible intangible heritage,social ecological systems,action research,malaysia
A Certification approach for dynamic, agile and reUSable assessmenT fOr composite systems of ICT proDucts, servicEs, and processeS (CUSTODES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Sweden,France,Italy,Belgium,Germany,Ireland,Greece,Cyprus,Netherlands,Spain,Switzerland
Call: Development and validation of processes and tools used for agile certification of ICT products, ICT services and ICT processes (HORIZON-CL3-2022-CS-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 6382922.5
EU funding (EUR): 4999158.25
Participants: 19
Project status: SIGNED

Cybersecurity certification as introduced by the EU Cybersecurity Act (EUCSA) will play a crucial role in increasing the trust to and security of ICT Products, ICT Services and ICT Processes. Cybersecurity certification is a complex process, posing a variety of challenges to the different interested parties. This proposal introduces the CUSTODES, a system comprised of a variety of components with the aim to provide trustworthy, cost-effective, agile and portable conformity assessment capabilities, to a variety of interested parties, covering multiple Assurance levels of Composite ICT products or ICT services. The CUSTODES system will discover and translate certification information of the Building Blocks of the composite ICT products or Services under evaluation, will provide Certification information to the interested parties and will share information on newly identified vulnerabilities related to the specific blocks or composite products as needed increasing transparency, re-usability and trust. It will also utilize a Restricted & Trusted Execution (RTE) Environment, to ensure the chain of custody of the product under assessment. CUSTODES will be validated in three pilots, a) one of two Class I composite products with digital elements, b) one of an ICT product with an embedded AI component and c) a final one of the as-a-service functionality through EIT Digital extensive digital ecosystem. The CUSTODES project is built on a collaboration of 17 organisations from 11 EU member states and third countries. The Consortium which includes 3 Conformity Assessment Organizations is composed by 10 SMEs, 3 large industry partners, 2 research organizations, and 2 public organizations/associations. The Consortium is led by RISE which has extensive experience in national and European research projects, and numerous collaborations with industrial partners.

Keywords: conformity self assessment,cybersecurity certification,eu csa,cra,assurance levels,composite product certification,testing
Green Surveillance: Imagining a Sustainable Internet of Things (GREENWATCH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The emerging Internet of Things (IoT) constitutes a communication system that enables comprehensive and continuous monitoring of the effects of human activity on Earth’s ecosystems, thus potentially facilitating the green transition to sustainable forms of social life. But the scope and the scale of the necessary monitoring simultaneously entails surveillance, not only of natural and built environments, but of persons and their actions as well, extending far beyond the online tracking of citizens and consumers which over the past decade has generated widespread public debate and motivated substantial legislation regulating digital infrastructures in the European Union and beyond. The GREENWATCH project anticipates and assesses the ethical dilemmas that follow from green surveillance: What kinds and which degrees of surveillance will the present human cohort be prepared to accept in the coming decades to ensure the livelihood of the species centuries and millennia into the future? Comparing the three world regions driving the development of IoT – Europe, the United States, and China – the study maps the empirical scenarios being projected for IoT as part of the green transition; theorizes the process of green surveillance as information feedback to national and international systems of governance as well as to individual citizens, consumers, and corporations; and evaluates both the scenarios and the practice of surveillance against the background of classic philosophical traditions of local and global social justice, complemented by recent conceptions of climate justice and environmental justice. Through IoT, Earth is sending a message that the human species is obliged to respond to, across ideological and civilizational divides, for survival and, at best, individual and collective human flourishing (eudaimonia).

Keywords: internet of things,green transition,europe,united states,china