Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Citizen Science as the new paradigm for Science Communication (NEWSERA)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Italy,Spain,Portugal
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 1299250.0
EU funding (EUR): 1299250.0
Participants: 6
Project status: SIGNED

Citizen science (CS) initiatives are changing the paradigm of science communication (SC). Not only the embedded bottom-up methodology takes into account people’s needs, aligning science to society, but empowers citizens to become science communicators. Moreover, launching a citizen science project requires the creation of a complex ecosystem, in which the participation of quadruple helix stakeholders (interdisciplinary scientists; public sector; industry; CSOs and society at large) is usually a must. This poses a challenge in terms of science communication due to: 1) the wide variety of specific science communication tools and strategies to be used for each target group, and 2) the required continuous feedback to each stakeholder group to maintain the engagement throughout the project. NEWSERA will analyse and evaluate the complex and multidirectional science communication strategies, including digital and non-digital ones, addressed to quadruple helix stakeholders in citizen science projects across Europe as the new paradigm for science communication. An assessment of the initial state-of-the-art of science communication in citizen science projects will be carried out. 4 pilot case studies will be selected from ongoing EU projects mapped under the EU-Citizen.Science platform, taking into account not only the quantity, quality, reliability and effectiveness of the communication, but also psycho-social factors such as the perception and trust on science communication and, in consequence, on science. One further case study will be addressed to science journalists. Innovative strategies will be co-designed for each stakeholder group in our Citizen Science Communication Labs to test the new concepts of Citizen Science Communication and Citizen Science Journalism, to reinforce the interface between science-society-policy and increase trust in science, while advancing the state-of-the-art in science communication.

Keywords: citizen science,data journalism,quadruple helix,inclusiveness,trust,open science,co creation,co design,ethics,public engagement,impact assessment
Game-changing uPAR-targeting dye for guiding surgical treatment of cancer (INSTAGLOW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-07-01
End date: 2022-12-31
Duration (months): 30.0
Total project cost (EUR): 5085250.5
EU funding (EUR): 2499868.69
Participants: 1
Project status: CLOSED

Surgery is a cornerstone in treatment of early cancer, used in 45% of all patients, although cancer commonly recurs after surgery due to incomplete removal. The residual tumour not only leads to avoidable suffering and even dying of patients but also presents a huge financial burden for the healthcare system. As such, there is a major unmet need to accurately delineate tumour from healthy tissue, identify local metastases, and aid surgeons to precisely remove the entire tumour. FluoGuide will deliver FG001, a breakthrough, real-time, surgical visualisation solution that lights up cancer and improve surgical precision during removal surgery. FG001 is the first active targeting fluorescent tumour marker that targets uPAR, a receptor extensively expressed (95%) in a wide range (>50%) of solid tumours such as brain (glioblastoma; GBM), breast, colorectal, lung and head and neck cancers. FluoGuide’s proprietary FG001 will revolutionise cancer surgery to improve the surgical outcome of >3 million cancer patients undergoing surgery every year. To realise this huge potential, FluoGuide is working on accelerating the development of FG001. Our initial focus is on GBM for which the prognosis is extremely poor with half of all patients dying within 14 months. Moreover, surgery is extremely challenging as removing too much brain tissue can severely disable the patient. FG001 can thus enormously improve surgery of GBM patients. The funding from EIC accelerator pilot will accelerate FG001’s clinical phase IIb/III study for GBM, and catapult FluoGuide to become a leader in cancer surgery guidance. We will generate revenues by 1) direct sales for compassionate use sales (2021) to showcase FG001, 2) direct sales in EU (2023), paid for via reimbursement by insurance companies and governments, and 3) roll-out to US and Asia (2025) through deals with large regional medical companies for local regulatory approval, and marketing and sales to ensure its full economic potential.

Keywords: fluorescent tumour marker,cancer surgery,precision surgery,intelligent surgical targeting,glioblastoma,brain cancer
BotsAndUS - First Assistant Robot For Retail And Hospitality (BotsAndUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The retail and hospitality sectors have been facing an international increase both in terms of demand and sophistication. However, they are facing a series of issues. For instance, online is threatening retailers, traditional hotels and event attendance, which offer the advantage of convenience, advocacy and smart, real time insights/data. Also, customers have become immune to marketing across all channels. In this context, it is crucial for the companies from these sectors to offer memorable, fund and useful experiences, which is the key to encourage and multiply visits and sales. BotsAndUS intend to take advantage of this context by offering companies that rely on face to face customer interaction a state-of-the-art robot. It is capable to interact with people of various genders and ages, to autonomously approach and engage in conversation, as well as react to emotions, all to offer outstanding customer service. The market size for retail robots will reach 10 billion euros in 2025, the annual reduction in the cost of manufacturing robots able to interact with humans will drop by 26%, whereas there will be 3o times more interactions per day between humans and robots. BotsAndUs aim is to develop a consumer robot, able to autonomously approach and engage in conversation, react to emotions. Our company puts the user at the centre of Human-Robot-Interaction and develops an innovative technology by combining social sciences, human-centred design and cutting-edge engineering. Bo is the first robot that combines various technologies from the ICT sector to obtain a “social robot”, which will be able to optimally interact with customers by engaging in conversations and adapt to various working environments and feedback from people. To ensure successful commercialization, in Phase 1 of SME Instrument, BotsAndUSintends to develop an elaborate feasibility study for Bo robot commercialisation.

Keywords: human interaction robot,retail and hospitality sectors,most advanced consumer robot
East-Asian Buddhism in Post-Apartheid South Africa (BUDDHISMAFRICA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-08-17
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Explorations of Buddhism in Africa are very few and have been so far conducted at the introductory level. Moreover, in the field of religious studies there is still a marked tendency to reduce the globalization of Buddhism to its worldwide missionary activities, and to neglect crucial factors such as the impact of deterritorialization and hybridization. BUDDHISMAFRICA aims to break new ground in this field of research by approaching these dynamics from an interdisciplinary perspective at the intersection of religious studies, sociology, anthropology, media studies, African studies, East Asian studies, gender studies, and global studies, as to provide for the first time a comprehensive and detailed analysis of East Asian Buddhism in South Africa, with a focus in the post-apartheid period (1994-present). BUDDHISMAFRICA has three research objectives, which will be pursued through ethnographic (participant observation, in-depth interviews) and archival research: 1) To analyze the trajectory of East Asian Buddhism in South Africa and its hybridization at the organizational/individual level. 2) To investigate the degree in which East Asian Buddhism has been able to reach out to black people, and to provide them with maps to navigate race and cultural identity. 3) To clarify the impact of informal spiritualities related to East Asian Buddhism on the South African religious context. BUDDHISMAFRICA will disseminate the research findings through peer-reviewed open-access publications (two articles and one monograph), an international workshop (and the publication of its proceedings), public talks for non-specialists, and project updates through the traditional/social media. Moreover, BUDDHISMAFRICA has put in place a detailed training program that is aimed, in collaboration with the supervisor/internal advisors and through the participation in dedicated workshops, to develop the applicant’s interdisciplinary, research management, teaching, and interview skills.
Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton (CellularLogistics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown. To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function. This research will uncover key mechanisms of cytoskeletal organization and transport in neurons. In addition, our techniques and concepts will aid understanding intracellular transport in other cellular systems.

Keywords: intracellular transport,microtubule organization,super resolution microscopy
Cerebellar mechanisms for governing goal-directed and social behaviours (CEREBELLARCODE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

One of the fundamental goals of neuroscience is to understand how the organization and the dynamics of the neural circuits underly their ability to drive adaptive behaviour. The cerebellar cortex provides a unique system to define such structure-function relationships due to its accessibility, well-defined architecture, and involvement in pervasive brain disorders as autism. Recent evidence suggests that the cerebellum may generate predictions to facilitate a variety of motor and non-motor behaviours, including cognitive processes. The question is how such a diversity of function emerges from such a homogenous structure. The aim of this project is to characterize the activity of the different cerebellar neurons during a wide range of states to underly their shared and diverging roles in different behavioural paradigms. First, I aim to develop a machine-learning based classifier for identifying cerebellar cell types from Neuropixels recordings. Then, I will use the classifier to characterize the activity of different cerebellar neurons in reward prediction and social interaction tasks. A direct projection from the deep cerebellar nuclei to the ventral tegmental area is believed to modulate both reward circuity and social interaction. However, the cerebellar mechanism underlying these two behaviours is unknown. I will measure and compare the activity of identified classes of cerebellar neurons in these behaviours. Finally, since autism is characterized by having both impaired social behaviour and impaired reward processing, I will also record from autism model mice in the social task. Understanding the computations implemented by the cerebellum in a variety of behavioural states will reveal general principles about how neurons process information and underlie brain function in ‘normal’ vs. pathological conditions.

Keywords: cerebellum,neural circuits,purkinje cells,electrophysiology,behaviour,neuropixels
Monoclonal Antibodies against 2019-New Coronavirus (MANCO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,Netherlands,Netherlands
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-03-01
End date: 2023-05-31
Duration (months): 39.0
Total project cost (EUR): 3034581.25
EU funding (EUR): 3034581.25
Participants: 8
Project status: SIGNED

Lessons learned from, and intervention efforts against SARS coronavirus (CoV), MERS-CoV and other emerging viruses provide invaluable information to accelerate the coordinated response against 2019 novel (2019 -n)CoV and the rapid development and manufacture of new diagnostic, prophylactic and therapeutic intervention strategies. A -promising approach to both patient management of emerging viral infections and to better preparedness and response to emerging epidemics is the use of monoclonal antibodies. MANCO aims at contributing to the rapid international response against 2019-nCoV, through preclinical and clinical evaluation of monoclonal antibodies against 2019-nCoV. MANCO will build on and leverage outstanding results from ongoing IMI-funded project #115760 ZAPI, including recently-discovered broadly cross-reactive H2L2 monoclonal antibodies against betacoronaviruses and an established pipeline for rapid identification of specific H2L2 monoclonal antibodies against 2019-nCoV; antibodies that will be selected to proceed to GMP manufacturing in high-yield CHO cell-lines. This project furthermore builds on ZAPI consortium’s experience and expertise for the development and establishment of relevant animal models, to ensure preclinical efficacy and safety, including absence of antibody-dependent enhancement, an issue seen to occur in some immunization studies against feline and SARS CoVs. Based on the generated preclinical data, MANCO will advance one lead (prophylactic and/or therapeutic) monoclonal antibody into a Phase I clinical trial that can be completed within two years of the start of the project, by leveraging clinical expertise, infrastructure and network currently in place for ongoing CEPI-funded projects on candidate vaccines against MERS-CoV (#INID1801) and Rift Valley Fever virus (#INLA1901), and H2020-funded projects on improved vaccines targeting the elderly (ISOLDA #848166) and on universal influenza vaccines, including in LMICs (ENDFLU #874650).

Keywords: monoclonal antibodies,prophylaxis,therapeutic,fast track,clinical trial,coronavirus
Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment (PLASTICHEAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Finland,France,Netherlands,Denmark,United Kingdom
Call: Micro- and nano-plastics in our environment: Understanding exposures and impacts on human health (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 5999571.25
EU funding (EUR): 5999571.25
Participants: 15
Project status: SIGNED

The exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic-waste that is continuously degraded into micro and nanoplastics (MNPLs). Information on the MNPLs effects on human health is still preliminary and, furthermore, the limitations in current methodologies prevent accurate human exposure/risk assessment. In this context, PLASTICHEAL aims at providing new methodologies and solid scientific evidence to regulators by combining the use of breakthrough research and validated test methods to set the knowledge basis for adequate risk assessment of MNPLs. PLASTICHEAL will be supported by an innovative experimental approach that will first generate human exposure estimates after identification, measurement, and characterization of MNPLs present in the environmental air, water and food sources, as well as in human biological samples of population groups with potential high MNPLs exposure levels (biomonitoring study) by means of adapting the existing analytical methodology proven useful for fibres and nanomaterials. Those estimates will then be complemented/ correlated with the output of kinetic models using data on MNPLs translocation, accumulation and destabilization of the Gastrointestinal and Respiratory Tracts, and with the MNPLs toxicokinetic in blood and secondary organs using in vivo models. Thereafter, immune effects, transforming effects, genotoxic effects, impact on transcriptome/epigenome/secretome (i.e. omics), stemness imbalance and potential molecular mechanisms of action and adverse outcome pathways in blood, primary and secondary organs will be studied under in vitro, in vivo, and ex vivo short and long-term (co)exposure settings. To ensure the impact of PLASTICHEAL’s developed methodology and gained knowledge on current and future regulation, a continuous dialogue will be established from the beginning of the project with policy makers and other key stakeholders of the plastic value chain. PLASTICHEAL is part of the European MNP cluster on human health (Name and acronym to be decided).

Keywords: micro and nanoplastics,analytical methods,risk assessment,long term effects,inmune effects,human biomonitoring,fate and bioaccumulation,multi omics,mechanism s of action
GeoLocLang (GeoLocLang)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 1301863.0
EU funding (EUR): 1301863.0
Participants: 1
Project status: SIGNED

I formulated recently a conjecture that should allow to geometrize the local Langlands correspondence over a non-archimedean local field. This mixes p-adic Hodge theory, the geometric Langlands program and the classical local Langlands correspondence. This conjecture says that given a discrete local Langlands parameter of a reductive group over a local field of equal or unequal characteristic, one should be able to construct a perverse Hecke eigensheaf on the stack of G-bundles on the "curve" I defined and studied in my joint work with Fontaine. I propose to construct, study and establish the basic properties of the geometric objects involved in this conjecture, this stack of G-bundles being a "perfectoid stacks" in the framework of Scholze theory of perfectoid spaces. At the same time I propose to establish the first steps in the proof of this conjecture, study particular cases in more details and explore consequences of this conjecture.