Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Horticultural innovations in soil-friendly practices to ensure a sustainable future (Hort2thefuture)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Denmark,Spain,North Macedonia,Italy,Netherlands,Serbia,Germany,Croatia,Hungary,United Kingdom,Belgium,Norway
Call: Soil-friendly practices in horticulture, including alternative growing media (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 6215332.0
EU funding (EUR): 5941413.25
Participants: 29
Project status: SIGNED

Europe’s horticultural production systems face 3 main sustainability problems: i) continued reliance on peat growing media, and drawbacks of current peat alternatives; ii) inefficient or inappropriate use of agricultural inputs; iii) suboptimal soil health due to unsustainable management practices. The multi-actor project Hort2thefuture will address these 3 challenges over 4 years with research, supplier, retail, and grower partners representing 11 European countries. Activities are divided between 7 Work Packages corresponding to the project's key objectives, together with project management. The objectives are to: (1) develop a methodological framework and tools for effective sustainability/Life Cycle Assessment analysis, (2) create and foster the commercial uptake of relatively low-cost, reliable, scalable growing media in horticulture, using EU-sourced raw materials, having substantially lower carbon and environmental footprints than peat, (3) develop and commercialise novel products and production systems that reduce input use in horticulture, (4) develop and commercialise novel products that improve soil structure and mitigate soil compaction in horticulture, (5) facilitate behavioural change to more sustainable practices through Living Labs and policy measures, and (6) communicate, disseminate & exploit project results effectively to 7 stakeholder audiences, raising soil literacy. The project will deliver outputs at TRL5-7 for Decision Support and LCA tools, an in planta nitrate monitoring electrode, new peat-free alternatives being commercialised, based on wood fibre, nano/micro-irrigation products developed to improve irrigation efficiency and soil health, as well as commercialised biological, chemical and mechanical solutions to reduce/prevent soil compaction, restore compacted soils and improve soil structure. These outcomes will help realise Mission: Soil health objectives, involving stakeholders along the whole agri-food chain and cooperation with FAO.

Keywords: horticulture,soil science,innovation,sustainability
Engineering Excited States, Orbital Coupling and Quantum Coherence Phenomena in Photoelectrochemical Energy Conversion Devices (Excited)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Excited aims to advance fundamental understanding to light-initiated reactions in molecular sensitizers that can display quantumcoherent behaviour in their excited state dynamics at room temperature. Moreover, it will focus also on the investigation of quantum coherent contributions to the solar-to-energy conversion efficiency in solar cells. Understanding the importance of quantum-coherent dynamics in biological systems has been key to assess whether this phenomenon is not just present but key for the control, and command, of the energy transport in molecular based systems. It is of utmost importance to validate models in which these quantum phenomena can be translated to materials that provide efficient solar to power conversion technologies. Excited is not only a project where molecular solar cells will be fabricated and their physical properties will be measured. Excited goes well beyond that, and will pave the way for the development of solar cells that will be tailor-made to make use of quantum coherence, molecular hybridization and orbital coupling effects to increase the solar to energy conversion efficiency. It is clear that this challenge can only be successful under the scope of a multidisciplinary perspective open to new and feasible reasonable hypothesis. Therefore, I will make use of the research group knowledge on synthetic chemistry that has allowed us to obtain numerous sensitizers for solar cells applications, as well as, for semiconductor metal oxides. Moreover, I will take advantage of our experience in advanced experimental time-resolved techniques to study quantum coherent effects and solar cells under operando conditions. Excited will have a key impact on several fields, from biology to chemistry and physics and will bring paramount breakthroughs in the use of modified interfaces leading to the optimization of novel thin film solar cell technologies taking advantage of the quantum coherence phenomena and orbital coupling effects.

Keywords: devices,exited states,quantum coherence,molecular
An integrated theory of deciding and acting (ITDA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1290180.0
EU funding (EUR): 1290180.0
Participants: 2
Project status: SIGNED

How do we translate information from sensory inputs and memory stores into goal-directed actions? In the last 40 years, the fields of cognitive psychology and cognitive neuroscience have focused on the decision-making stage, and very few attempts have been made to understand the complete process. The aim of the present scientific proposal is to elaborate an integrated computational theory of deciding and acting in humans, which explains conflicting measurements from these traditionally separate fields of research, and provides joint, precise quantitative predictions about them. The core hypothesis of the theory is that motor execution is determined by the same evidence accumulation variable that drives decision-making. This hypothesis strongly departs from current models of decision-making that represent motor execution as a residual parameter, under the assumption that motor execution captures effects that are not cognitively interesting. The theory will be tested through a series of experiments that combine cognitive modeling, behavioral and electrophysiological measurements (electromyography of response-relevant muscles and electroencephalography). Specifically, the experiments aim at (i) testing and characterizing the hypothetical dependency of motor execution to the evolving decision variable, (ii) generalizing the theory to a wide range of choice laboratory tasks and different response effectors, (iii) identifying potential boundary conditions of application, and (iv) elucidating the relationship between decision-making, motor execution, and confidence judgments. In a final part of the project, the theory will be applied to developmental data, in order to provide new theoretical insight into the development of decision-making and motor execution across the lifespan. If successful, this work should provide new perspectives into a broader range of research problems, from perception-action coupling to movement disorders that appear to have a cognitive basis.

Keywords: decision making evidence accumulation models drift diffusion model cognitive modeling motor execution electromyography electroencephalography
Development of artificial phosphoinositides aiming at HIV eradication (Super-HIPPO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Türkiye
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: CLOSED

Main challenge of fighting with the HIV is to eliminate the latent viral reservoir from the body. This reservoir is resistant to antiretroviral drug therapy and can cause viral rebound if the treatment is stopped. The removal of the reservoir enables HIV eradication, is urgently desired in HIV-AIDS research. For this purpose, a strategy called “kick and kill” was proposed, based on the hypothesis that activation of latent HIV (“kick”) leads to cell death (“kill”) by physical damage and/or immune activation. However, in clinical tests “kill” process was found to be not enough to reach HIV eradication. To eradicate HIV from the body, my work has recently suggested a new strategy called “lock-in and apoptosis” instead of “kick and kill”. In development of this strategy, non-natural derivative of inositol hexaphosphate (IP6) named as L-HIPPO was designed based on the fact that the MA domain of Pr55gag which mediates membrane binding through its interaction with inositol phospholipid PIP2 in the host membrane. L-HIPPO was administrated to HIV infected HeLa cells as complex with a carrier α-CDE and suppressed membrane localization of HIV-1 Gag protein and induced strong apoptosis of the host cell containing the latent viruses. In contrast, α-CDE-L-HIPPO induced less apoptosis on T cell line. Besides, the complex of α-CDE-L-HIPPO is inapplicable for oral use. Toward this end, new L-HIPPO derivative with alternative carrier is required. An ultimate goal of this work is to develop new L-HIPPO derivative (Super-HIPPO) with more potent and efficient activities. My objectives to reach this goal are (1) to synthesize new L-HIPPO derivatives and alternative carriers, (2) to evaluate their activities, (3) to repeat design, synthesis and biological evaluation, if the activities are not enough, (4) to confirm the binding mode of MA-compound, and (5) to achieve personal development and career advancement by performing this study.

Keywords: inositol hexaphosphate,nanoparticles,hiv 1,matrix protein,and x ray crystallography
Modelling the chemiosmotic mode of ATP synthesis in protocells (ChemiLUCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

All modern organisms feature chemiosmosis (ion-motive-force driven processes, including membrane transport and ATP production), and therefore the Last Common Universal Ancestor (LUCA) is believed to be chemiosmotic; although contradictorily. As for chemiosmosis to happen, cells utilise membranes relatively impermeable to the coupling ion (H+ or Na+). It has previously been shown that, theoretically, LUCA could drive chemiosmosis using a geo-chemical H+-gradient but only if it had a leaky membrane. However, a leaky membrane rapidly achieves electrochemical equilibrium offsetting the H+ influx. For the H+ influx, and therefore chemiosmosis, to continue, the membrane needs a system to pump H+. Paradoxically, pumping H+ across a leaky membrane is futile. A potential solution has previously been hypothesised in the form of membranes leaky to H+ that harboured: an ATP-synthase coupled to both H+ and Na+, and an antiporter that pumps out Na+ for incoming H+. Such a Na+/H+ antiporter could convert the geochemical H+ gradient into a Na+-gradient. It would be advantageous to do so as a Na+-gradient could be better sustained by the LUCA membrane and could drive ATP production via the promiscuous ATP-synthase. My project aims at obtaining empiricalmvalidation for this hypothesis. To do so, a promiscuous ATP-synthase will be co-reconstituted, alongside a Na+/H+ antiporter, into fatty-acid-containing hybrid liposomes (made from fatty acids and other amphiphilic (phospho)lipids). Ion-gradients will be imposed on the liposomes by pH-jump or decarboxylase-catalysed alkalisation methods to test whether the system could: a) convert the H+-gradient into a Na+-gradient via the Na+/H+ antiporter, and b) use the Na+- gradient to drive ATP production via the promiscuous ATP-synthase. This study is critical to understand the evolution of chemiosmotic systems and will have implications in evolutionary and synthetic biology as well as astrobiology.

Keywords: membrane biology,chemiosmosis,origin of life,last universal common ancestor,protocell,membrane transport bioenergetics,membrane transport,atp synthesis,ion motive force
OneTick: An Integrated One Health Approach for Prevention, Detection and Treatment of Tick-Borne Diseases in Urban and Peri-Urban Environments (OneTick)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland,Germany,Czechia,Austria,Norway,Romania,Spain,Sweden,Netherlands,Denmark
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 476665.71
EU funding (EUR): 450900.0
Participants: 12
Project status: SIGNED

Tick-borne diseases (TBDs), caused by bacteria, viruses, or protozoa, present a significant health and socioeconomic challenge in Europe. Historically centered in Central and Eastern Europe, Lyme disease and tick-borne encephalitis (TBE) are prevalent in Austria, Germany, and the Czech Republic, with their range expanding due to climate change. Reports show a rising incidence of TBDs in Northern Europe, with about 24% of Europeans living in high Lyme borreliosis (LB) areas as of 2022. It is further heightened by the tick collonization of urban and peri-urban environments where the risk of a tick bite is much higher due to the larger population density of humans and pets. TBDs impose a considerable burden on European societies, with the ECDC estimating around 360,000 Lyme cases in 2016, leading to societal costs of approximately 280 M EUR annually. OneTick, under the One Health framework, aims to enhance the prevention, detection, and treatment of tick-borne diseases in urban areas. Work Package 1 investigates urban tick adaptation, assessing their abundance, species diversity, and pathogens. Work Package 2 examines tick-host-pathogen interactions to develop predictive models for disease spread. Work Package 3 aims to enhance diagnostics through the identification of disease biomarkers and the development of predictive models for survival rates. Lastly, Work Package 4 focuses on raising public health awareness through guidelines and educational campaigns to combat misinformation. In OneTick each participating organization contributes unique expertise, forming a radial structure that integrates diverse scientific perspectives and fosters harmonization of methodologies across disciplines and sectors. We plan to implement 90 PM of secondments, incl. 60 intersectoral and 30 interdisciplinary staff exchanges. Through secondments, we will disseminate best practices, enhance interoperability, and establish shared frameworks for tick-borne disease research and surveillance.

Keywords: tick one health tbe tick borne diseases rickettsiosis
Our sustainabLe futurE, the ValuEs that dRive it, and how to get there (LEVER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1222194.0
EU funding (EUR): 1222194.0
Participants: 1
Project status: SIGNED

Grand and persistent social-ecological challenges, such as climate change, push forward a rapidly growing discourse on how sustainability science can support society in dealing with today’s global crises. Between studying change and contributing to change, sustainability science seeks both to analytically understand sustainability problems, but also to design interventions that can contribute solution-options to these problems. However, knowledge about how to intervene in order to reach a desirable vision (i.e., transformation knowledge) is typically missing. Especially how to deliberately engage with values as places of intervention (leverage points), as proposed by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, remains a critical knowledge gap. To fill these gaps, LEVER aims to critically develop and apply a transformative theory and practice to support the (co-)production of transformation knowledge, including a focus on transformation knowledge necessary to investigate and unleash values as leverage points for sustainability transformation. To this end, LEVER originally combines transdisciplinary research with the empirically rigorous methods of social science experiments. The scientific breakthrough consists in delivering an integrated theory of transformative research, capable of representing the many co-evolving links between its design principles, philosophy of science, normative assumptions, and ethical dimensions. Methodologically, LEVER opens new avenues on how to produce transformation knowledge, by experimenting with, testing and evaluating novel transformative methods. Finally, LEVER seeks to answer the globally relevant and timely question of how to unleash values. Using a treatment and control group experimental design, LEVER assesses the impact of values-targeting interventions and demonstrates the potential of values as leverage points. LEVER pioneers a salient conscious science-society relationship in Europe.

Keywords: transdisciplinary co production of knowledge,sustainability transformation,leverage points,values,peri urban,rural urban
Sensor-based technological platform to investigate the effect of age-induced changes of oral physiology on the bolus properties and on the subsequent phases of swallowing and digestion (SENSINGTech)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The main goal of oral processing is preparing food for swallowing and digestion, where mastication determines the effective surface area of food particles and food bolus properties. Ageing induces changes in oral physiology leading to substantial alterations in bolus properties, bioaccessibility, and bioavailability of nutrients. The impact of age-related alterations on swallowing and digestion can be intensified by health conditions that may cause dysphagia. SENSINGTech is an interdisciplinary research project that, integrating a full sensor-based technological platform, aims to investigate the evolution of food properties in mouth, and the dynamics of food oral processing and saliva addition on bolus formation, to quantify its impact on both swallowing and the delivery of nutrients. This work aims to provide clear-cut boundaries of food characteristics that ensure a safe swallow. The key limitation of working with vulnerable people to accurately measure mastication, swallowing and digestion will be overcome by developing a quantitative in vitro approach that mimics the human feeding process, monitoring the “Stage II of transport” for solid food intake – not captured by any in vitro system yet. This project will enable the fellow to acquire a strong competence in food oral processing, swallowing, and digestion, learning new methodologies and applications to meet the challenges linked to population ageing and the management of dysphagia. This research will address the Horizon Europe (HE) efforts devoted to “Health”, where the unique combination of expertise will lead the candidate towards an independent scientist career of high quality and strong international visibility. SENSINGTech will therefore be a milestone for the future research career of the applicant, positioning both the fellow and the host in leading positions in food oral processing and the dysphagia research field.

Keywords: mastication food oral processing dysphagia swallowing digestion