Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regeneration of Injured Spinal cord by Electro pUlsed bio-hybrid imPlant (RISEUP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 42.0
Total project cost (EUR): 2999836.25
EU funding (EUR): 2999836.25
Participants: 6
Project status: SIGNED

Spinal Cord Injury (SCI), a major cause of paralysis, currently has no effective therapies. Every year almost 500.000 people are diagnosed with SCI worldwide. In Europe, the average investment is up to 2 M€ per patient in health care. The difficulty on the neuronal restoration after SCI is based on the complex cascade of events that inexorably cause a degenerative chronic stage mainly favored by the non-permissive environment and limited capacity for axonal regrowth. Multifaceted strategies are considered the unique solution for functional restoration by including cell substitution, neuroprotection and axonal growth promotion. RISEUP proposes to attain neuronal functional regeneration after SCI by an unprecedented and unique bio-hybrid-compatible electro-activated and wireless-rechargeable implantable technology. RISEUP introduces high voltage microsecond electric pulses (micropulses) stimulations and low amplitude direct currents on a combination of stem cells (induced neural stem cells and multipotent stromal cells), whose transplantation is facilitated by an innovative scaffold biomaterial. The RISEUP concept is that micropulses, being able to impose and control cytosolic Calcium oscillations, will facilitate cell maturation, survival and neurotrophic factors secretion. Because Calcium signaling is essential for neuronal activity, endogenous neuronal re-connections will also be favored. RISEUP goal, even if ambitious, is concrete due to the multidisciplinary partners’ competences, initiating from TRL1 a radically new line of technology (electro-activated, remotely controlled, biocompatible, biodegradable cell-containing implants for the repair of neuronal lesions) establishing its proof-of-principle (TRL3). The long-term vision of RISEUP is the radical change in SCI treatment modality to assure the cure delivery without any machinery connection, dramatically improving patients’ quality of life.

Keywords: spinal cord injury,microsecond electric pulses,cells electromanipulation,calcium signalling,wireless controlled electrified biohybrid scaffold,stem cells transplantation
Do Particle Properties Modulate bioaccumulation, Trophic Transfer and biomagnifications of engineered nanomaterials: Role of Particles size, shape and surface coating? - BTBnano (BTBnano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

BTBnano will use state of the art knowledge and techniques to quantify single-walled carbon nanotubes (SWCNTs) and gold ENMs in cells and tissues. The objectives are to: (1) systematically quantify bioaccumulation and biodistribution of SWCNTs (as a function of size) and Au ENMs (as a function of size, shape and surface coating) in Daphnia magna and Danio rerio at chronic exposure conditions, (2) study the influence of particle size, shape and surface coating of Au ENMs and size of SWCNTs on their trophic transfer along an aquatic food chain, and (3) study the potential for biomagnification of SWCNTs and Au ENMs in the food chain when mass and particle number concentration are considered as dose metrics and develop a model for predicting biomagnification of ENMs based on the proper dose metric. Bioaccumulation and biomagnification of Au ENMs will be quantified by measuring mass and particle number concentration using inductively coupled plasma (ICP)-mass spectroscopy (MS) and single particle (sp)-ICP-MS. (sp)-ICP-MS will also be used to differentiate between ionic and particulate bioaccumulation of Au ENMs. Laser ablation-ICP-MS will be used to in situ quantify cell-to-cell heterogeneity of the intracellular distribution of Au ENMs. Combination of thermogravimetric analyser with fourier transform infrared and gas chromatography/mass spectrometry will be optimized for quantification of SWCNTs in tissues. The novelty of the project is in developing approaches for quantification of carbon-based and metal-based ENMs in biological matrices. BTBnano includes both training me in new advanced techniques and transferable skills and the transfer of knowledge to the host institution. Results have the potential capacity to support the ENM risk assessment and provide room for further studies in nanotoxicology and nanomedicine. This project is in line with the EU policy to protect the environment and to minimise risks to climate, human health and biodiversity.

Keywords: nanomaterials,ecotoxicology,risk assessment,bioaccumulation,biomagnification,fish,inductively coupled plasma mass spectroscopy,analytics,environmental science
Developing Inclusive & Sustainable Creative Economies (DISCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Sweden,Finland,Latvia,United Kingdom
Call: Inclusive and sustainable growth through cultural and creative industries and the arts (H2020-SC6-TRANSFORMATIONS-2018, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 2940495.0
EU funding (EUR): 2940495.0
Participants: 6
Project status: CLOSED

The DISCE (Developing Inclusive & Sustainable Creative Economies) project is set to improve and enhance the growth, inclusivity and sustainability of the cultural and creative industries (CCIs) in the EU. Overall, the ambitious objectives of DISCE are: i) to support the development patterns of CCIs within the EU through research on new business models and inclusive growth; and ii) to re-shape understanding of what ‘inclusive and sustainable growth’ consists of in this context, shifting the CCIs (and CCIs policy) towards strategic goals of ‘cultural development’ that encompass both GDP and human flourishing. DISCE is an interdisciplinary, mixed-methods project that builds on three pillars: 1) Robust statistical analyses, mapping and development of new statistical indices for a better understanding of the inclusive and sustainable development of CCIs in Europe; 2) In-depth case studies developing rich findings and nuanced understanding of the Creative Economies and their ecologies; and 3) Active co-creation and interaction with stakeholders to validate the policy relevance of the project, as well as the policy outcomes and achieve long-term impact and sustainability. DISCE serves all the beneficiaries relevant research results, which will help and support stakeholders to fill existing information gaps in daily policy and decision-making processes. DISCE will bring out recommendations for actors how to react, function and decide in specific situations to promote inclusive growth and progress on the sustainable development in the field of CCIs. The DISCE Consortium has six partners: University of Turku (UTU) as the Coordinator, Kings College London (KCL), Social Science Area of the Gran Sasso Science Institute (GSSI), Stockholm School of Economics in Riga (SSE) as ‘Research Partners’ and two ‘Stakeholder Partners’ Culture & Media Agency aisbl (CUMEDIAE) and Trans European Halles (TEH) both with wide networks in the field of CCIs.

Keywords: cultural andcreative industries,growth,inclusivity,sustainability,innovation,skills,higher education,indicators,statistics,cultural diversity,business models,employment,co creation,policies
The fourth estate? media, frames and political behaviour towards the EU in comparative perspective (MEDPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-11-06
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

How do the media report EU affairs, and to what extent may such coverage shape public attitudes and behaviour towards integration? MEDPOL aim is twofold: to investigate how media coverage of the EU has evolved since the signature of the Treaty of Maastricht in 1992 until today, and to assess the impact of news content and frames on political attitudes and behaviour towards the EU in different member states. Drawing on various disciplines - Political Science, Communication Studies and Political Economy - the project follows a mixed methods approach grounded on agenda-setting and framing theories. It consists of a qualitative and quantitative analysis of media content in four states: Italy, Portugal, Spain and France. Manual and automated coding of press content and Natural Language Processing (NLP) techniques will be used to analyse large amounts of textual data while maintaining rigorous methodological standards. MEDPOL brings together content analysis, electoral data and open-access social and economic indicators in order to analyse how issue visibility and media framing may influence electoral behaviour in different countries and social groups. Findings will further our understanding of how certain terms or sentences have been used to frame EU affairs and to express different ideas about the EU. MEDPOL analyses how these frames emerge and evolve over time, and through which mechanisms they may compete with each other and contribute to political polarisation. Finally, MEDPOL contributes to the diffusion of content analysis techniques, mixed methods and interdisciplinary approaches devoted to understand the role of the media as a political actor. Outputs include two peer-reviewed publications, a monograph, an open-access code that allows the method to be adapted to other cases, an academic workshop, a series of evidence-based comments aimed at a non-specialised audience (journalists, policy-makers, watchdog organisations), and public engagement activities.

Keywords: political attitudes and behaviour towards eu,media framing,content analysis,mixed methods,topics model,supervised machine learning,comparative analysis,press,france,italy,portugal,spain
Holocene climate reconstructions from western Anatolia based on speleothem data (SPELEOTOLIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-02
End date: 2021-11-01
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: CLOSED

Speleothems (calcareous cave deposits) are among the most useful archives that are utilized to reconstruct past environmental conditions, including palaeotemperature and moisture conditions, on decadal to millennial timescales. Highquality (high-resolution, precisely dated, complete, and robust) regional speleothem-based palaeoclimate records, specifically revealing the past variability of rainfall regimes, is of great importance for human water, and hence for the future estimations pertaining the human-climate-environment relationship. Research suggests that decreases in rainfall-driven water availability during the late Holocene in the Eastern Mediterranean region was one of the main reasons for the decline and/or collapse of some former civilizations (e.g., decline of Ottoman Empire in the preindustrial era, collapse of Uruk society in Mesopotamia during the transition from chalcolithic to the early Bronze Age, societal collapse of the Late Bronze Age). This project will generate an extensive dataset through a multi-proxy approach of isotope and trace element geochemistry using Holocene-aged stalagmites from several cave sites located in western and southwestern Anatolia (Turkey). The main objectives of the proposed action are: (1) to produce precisely-dated (U-series dating) and high temporal resolution paleorecords concerning the Holocene climate dynamics that affected the living patterns of ancient Aegean civilizations (e.g., Classical Greek and Roman), (2) to trace possible impacts of human-induced environmental and atmospheric pollution through a suite of high resolution stalagmite records, including stable isotope and trace element variations (e.g., changes in carbon and sulphur isotope ratios), and (3) to explore whether the speleothems reflect Holocene volcanic activities that occurred in the Aegean region, and if so, to distinguish these effects from anthropogenic activities.

Keywords: paleoclimate,paleoenvironment,holocene,speleothem,u series dating,stable isotope,trace element,eastern mediterranean,western anatolia
AI-BASED BROKERING TECHNOLOGY PLATFORM TO FIND THE PERFECT MATCH BETWEEN THE CUSTOMER AND BANK (IRMELI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-02-29
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For consumers, it is laborious and time-consuming to find and compare loan providers. Without the comparison, customers waste money and gain less beneficial terms of contract with the non-optimal bank. LVS Brokers is a fintech company that has developed an AI-based brokering technology platform and provides brokering services in the financial industry, e.g. to banks and lenders. Brokering service finds the perfect match between the customer and bank. The innovative AI-based LVS platform develops itself based on previous and new decisions and is scalable to other areas and all languages. The unique AI-based technology digitalises and automatises the work that competitors perform mainly manually. Proof-of-concept on national market in Finland shows high success and client need: currently the loan application volume is over 4 B€, the company has over 400 000 customers, and over 40 service providers are using the platform. LVS Brokers delivers more business for banks and other companies, such as electricity companies, real estate agencies and insurance companies, and it saves time and money for corporate and consumer customers in brokering processes. The company targets emerging global market on online brokering services and has multiple scalability opportunities in service and market sectors. The commercialisation is well prepared, and the Phase 1 feasibility study will produce the detailed business plan to support the scale-up. The target is to reach 350 M€ growth during the 5-year period (2% market share). LVS Brokers has a talented and dedicated group of 7 with in-depth international business and industry expertise and technology understanding in the fields of software, AI, machine learning engineering and integrations. Ongoing recruitments and an active network of relevant partners and stakeholders support the scale-up.

Keywords: machine learning,brokering,loans,service business,consumers,technology development,platform
Access to European Infrastructure for Nanoelectronics (ASCENTPlus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Italy,Ireland,Germany,Belgium,Belgium,France,France,Portugal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 9853821.0
EU funding (EUR): 9853570.0
Participants: 15
Project status: SIGNED

Advancing and broadening the first ASCENT programme, ASCENT+ will integrate additional key European infrastructures to address emerging research challenges in Nanoelectronics and enable a smooth consistent transition of the European industry to a new era. At present academic researchers and technologists struggle to develop industry-relevant disruptive technologies as there is limited access to state-of-the-art processing, modelling/data sets, metrology/characterisation, and devices/test structures for Nanoelectronics. Through the Single Entry Point and a user-focussed Access Interface, ASCENT+ integrates a unique research infrastructure of more than €2.5bn investment to offer these enabling capabilities to its users. ASCENT+ includes academic partners to advance the offering over the lifetime of this second Advanced Community phase, and also an extended network of over 3,700 members through partner research and industry cluster organisations. This will allow ASCENT+ to mobilise a critical mass of people, knowledge and investment to entrench an unprecedented integration within the community. This will service a much wider user base and foster innovation by linking new scientific knowledge in Nanoelectronics with challenge-driven research. European and global foresight studies have indicated that the next era is driven by the need to achieve: (i) quantum advantage using solid-state platforms; (ii) low-power, energy-efficient, high-performance computing based on disruptive devices; and (iii) increased functionality through advanced integration of a diverse range of materials and innovative technologies. ASCENT+ will enable and stimulate its user community to bridge the gap between scientific exploration and development of proof-of-concept technologies to accelerate innovation pathfinding. ASCENT+ presents a unique opportunity for Europe to regain global leadership in Nanoelelectronics at a pivotal time where traditional scaling is coming to an end.

Keywords: nanofabrication,beyond cmos,advanced memories,finfets,3d soi,3d integration,electrical characterization,2d materials,quantum dots
International consortium for integrative genomics prediction (INTERVENE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Italy,Italy,Austria,Germany,Germany,Belgium,Finland,Norway,Switzerland,United States,Netherlands,United Kingdom,United Kingdom
Call: AI for Genomics and Personalised Medicine (H2020-SC1-FA-DTS-2020-1, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 10434940.0
EU funding (EUR): 10434940.0
Participants: 19
Project status: SIGNED

The aim of INTERVENE is to develop and test next generation tools for disease prevention, diagnosis, and personalised treatment utilizing the first US-European pool of genomic and health data and integrating longitudinal and disease-relevant -omics data into genetic risk scores. Resulting in unprecedented potential for prediction, diagnosis, and personalised treatments for complex and rare diseases. Some of the largest biobanks in Europe and two in the USA will be securely linked and harmonized in a GDPR-compliant repository with data from more than 1.7 million genomes. INTERVENE will demonstrate the potential and benefits of powerful AI technologies on the next generation of integrative genetic scores (IGS). The clinical and economic benefits of IGS will be evaluated in key disease areas with major public health burden. Here, the newly developed IGS will be taken into clinical environment and their real-world benefits will be evaluated together with clinical experts, European patients advocate groups and medical societies and considering regulatory and ethical implications. Thus, a framework for legally and ethically responsible translation into wider clinical practice will be developed. Moreover, the partners will develop and test the role of IGS in several rare diseases as well as COVID-19 infection and severity. Importantly, to support the application of IGS via public-private partnerships including clinical practitioners, an AI-enabled federated data analysis platform, the ‘IGS4EU’ platform, will be developed for automated IGS generation and interpretation for end-users. Additionally, the IGS4EU platform will allow access of the INTERVENE data and the methodology know-how to the AI community through a competition-based benchmarking environment. In the long term, the IGS4EU platform aims to grow the disease coverage and enable a wide adoption of IGS as a gold standard in clinical research and practice.

Keywords: complex disease,rare disease,biobank,genomics,longitudinal health data,polygenic risk scores,predictive genetic scores,personalised treatment,disease prevention