Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DIGItal and BIOpolymer assisted RAILway embankment reinforcement (DIGI-BIO-RAIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2024-02-29
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: SIGNED

Railway embankments are at the risk of serious deformation caused either by the dynamic loads from moving vehicles, geohazards or both, and as such pose a threat to not only safety, but comfortable rail operations. Given that Europe cannot always be building its way out of ageing railway infrastructure, it must therefore retrofit and complement existing assets with new technologies. Moreover, the ability to predict and repair damaged railway earthwork in a cost-effective and time-efficient manner to ensure a safer, more reliable, efficient, sustainable and resilient railway earthwork infrastructure offers a great value not just to transport network operators but also to utilities, insurance companies and government agencies. Therefore, this fellowship improves the resiliency of railway earthwork infrastructure and mitigates potential economic, life, and property losses resulting from failure to apply a systematic approach. A toolkit and platform to enable the integration of resiliency-improving forecasting will be developed by combining traditional laboratory and field studies, data mining, machine learning, uncertainty quantification and reliability-based design so to utilize the data to its full potential, and an ecofriendly reinforcement control by using biopolymer for railway embankment deformation. This project will address critical gaps remaining in our understanding of the life cycle performance of biopolymer-reinforced railway earthworks related to material synthesis, degradation, repair as well as the interaction with the soil ecosystem through integrated geochemical and geotechnical experiments and numerical modeling.

Keywords: ground reinforcement,traffic load,engineered building material
A disruptive pre-assembled Self-Regenerating solvent Recovery Plant based on the vapor recompression principle in order to diminish the emission of volatile organic compounds to environment. (SRRP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The amount of volatile organic compounds (VOC) emission exceeds 15 MT/year in the world and 4 MT/year in Europe. These discharges constitute enormous environmental pollution and lead to serious health problems, such as respiratory insufficiency and asthma. Most of these emissions are caused by solvent-laden streams by companies in the packaging, chemical, degreasing and printing sectors. Solvent Recovery is a well-known technology that, although it has been extensively used by big companies within Oil & Gas from 1980, it is neither cost-effective nor adapted to small projects due to its intrinsic nature, requiring a boiler and a cooling system. As a consequence, thousands of tons of solvents, worth close to 1€/kg, are lost by SMEs within these markets and are discharged in polluted streams of air and water. SITES here proposes Self-Regenerating Recovery Plant (SRRP), a new technology able to generate steam without boiler and reject heat without cooling system, achieving the same effect in a more compact cost-effective installation. It absolutely adapts the system to SME main requirements, solving the following issues: • Cost: 85% reduction from 4.5 M€ to 0.65 M€ • Construction time: from 1 year to 2 days • Footprint: only 24m x 4m against the previous 50mx50m • Energy consumption: down to 1 kWh per kg of solvent instead of 2 kWh/kg • Minimum capacity: as low as 5,000 Nm3/h vs previous 30,000 Nm3/h • Safety: avoiding problematic operation by reducing regeneration temperature • O&M: simplifying it by deletion of boiler and cooling tower Additionally, global society shall be positively impacted because of the following points: • Save of 6281 tonnes/year GHG emissions • Avoidance of 4536 tons emission of VOC Solvents per installation • Save of 24.500 kg/h of water per average installation All in all, we intend to launch the product in 2021, achieving accumulated profits worth 5.95 M€, a ROI of 3.25 and creating 20 new jobs all within 5 years.

Keywords: solvent recovery,vapor re compression,distillation column,packaging
Innovator-Centered Systemic Acceleration of Low-carbon Energy Solutions (IC SALES)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Netherlands
Call: Ensuring greater synergies by testing new collaboration mechanisms between the EIT Innovation Communities and the Enhanced EIC Pilot in support of the the Green Deal and other Union policy priorities - Energy (H2020-IBA-EIC-ENERGY-2020, 2020)
Start date: 2021-07-01
End date: 2023-05-31
Duration (months): 23.0
Total project cost (EUR): 999926.75
EU funding (EUR): 999925.75
Participants: 1
Project status: SIGNED

The overall objective of IC SALES is to ensure greater synergies between the Enhanced EIC Pilot and EIT InnoEnergy in support of the Green Deal and other European Union policy priorities, to be deployed under Horizon Europe. IC SALES will achieve this objective though: 1. Establishing a tested, innovator (customer)-centered and business-oriented, coordination mechanism, notably around • seamless flow of innovative business cases from the EIC Accelerator to EIT InnoEnergy and vice versa, • leveraging of the EIT InnoEnergy eco-system and topical expertise for de-risking innovative business cases funded by the EIC Accelerator Pilot, • investigating and defining the possibility of co-investments, 2. Supporting a significant number of innovators funded by the EIC Accelerator Pilot which are not already connected to EIT InnoEnergy. 3. Supporting a significant number of innovators from the portfolio of EIT InnoEnergy to connect to the EIC Accelerator pilot. 4. Supporting a conducive eco-system (capital, connectedness, competence) in low-carbon energy. 5. Extending the benefit of EIT InnoEnergy Business Acceleration Services to innovators receiving the EIC’s Seal of Excellence Those objectives are fully in line and highly relevant for the Work Programme’s objectives of delivering a successful European Green Deal (climate-neutral EU 2050 and Green Recovery) and ultimately stimulating impact, i.e. market-creating breakthroughs for a resilient, competitive EU economy (growth, jobs, industrial leadership).

Keywords: business acceleration services,eic accelerator,eit innoenergy,innovator,entrepreneur,eu innovation area,low carbon energy,customer oriented,coordination mechanism
Exploration of the 2D-Chemistry of Black Phosphorous (B-PhosphoChem)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-08-01
End date: 2022-07-31
Duration (months): 60.0
Total project cost (EUR): 2491250.0
EU funding (EUR): 2491250.0
Participants: 1
Project status: CLOSED

We propose the development of the chemistry of black phosphorus (BP). B-PhosphoChem will constitute a new text book chapter in the realm of synthetic chemistry located at the interface of inorganic-, organic-, and materials chemistry as well as solid state physics. B-PhosphoChem will provide the basis for exciting and so far elusive applications such as ion batteries and stable high performance devices. Thin sheets of BP represent a new class of 2D materials and have recently raised tremendous interest in the scientific community. Outstanding physical properties such as high charge carrier mobility, combined with transparency and the persistence of a band gap have been discovered. However, the chemistry of BP remains still unexplored. B-PhosphoChem will close this gap and will a) provide the opportunity to modulate and fine tune the physical properties, b) allow for considerably improving the processability and increasing the solubility, c) establish concepts for the desired chemical stabilization, d) give access to the combination of BP properties with those of other compound classes, e) reveal the fundamental chemical properties and reactivity principles, and f) provide methods for establishing practical applications. Five work packages will be addressed: 1) Production of Thin Layer BP, 2) Supramolecular Chemistry of BP, 3) Intercalation Compounds of BP, 4) Covalent Chemistry of BP, and 5) BP-Based Materials and Devices. The work packages will be supported by systematic calculations. For our group, whose core competence is synthetic organic and supramolecular chemistry, the orientation towards inorganic phosphorus chemistry constitutes a major step into a completely new direction. However, we are convinced to be the most predestinated research group in the world successfully facing this challenge because of our leadership and well documented interdisciplinary experience in synthesizing and characterizing 0D-, 1D-, and 2D nanostructures.
Bioinspired Composites Strategies for Saving Energy (BioCom4SavEn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1694375.0
EU funding (EUR): 1694375.0
Participants: 1
Project status: SIGNED

Saving energy together with energy harvesting is demanded by increasing power consumption. The energy industry requires new materials not only for construction but also in cabling infrastructure. Moreover, the trend of portable and small devices causes a significant challenge in heat dissipation technologies. The need for sustainable technology in thermal insulation and cooling solutions to decrease power consumption requires new innovation. My ambition is to bring novel solutions inspired by nature to the thermal management challenges such as: - constructing light and more efficient thermal insulation; - developing cooling system based on the fibrous membranes to dissipate effectively heat, both leading to lower power consumption; - building mechanically robust and integrated system with conductive or piezoelectric properties, including thermal insulation and cooling system designed together for small devices and smart textiles. The aim of the project is therefore to both comprehensively evaluate natural design strategies and develop structural equivalents using novel composite manufacturing routes. Key to composite production is electrospinning allowing engineering the novel composites based on the porous membranes that will transform thermal energy management efficiency, allowing to increase the savings in daily life. The novelty of the project is the combined effort of complex composite membranes that have been never performed before. The interdisciplinary team of postdocs and PhD students working in parallel on the divided but interlayered topics, will lead to break-through in engineered multifunctional thermal materials for various geometries from buildings to cables.

Keywords: electrospinning,fibers,polymers,thermal insulation,biomimetic,cooling,pores,porosity,membrane,composite,energy
Elucidating the molecular basis of fruit resistance to desiccation: The cuticle as a key factor (3F-FutureFreshFruit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-15
End date: 2018-10-19
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

Water stress is a key environmental factor that causes important quality and economical losses before and after fruit harvest. As water depletion is becoming increasingly problematic, improving water efficiency and tolerance of plants to dehydration is a priority of the European Union, as reflected in the societal challenge of Climate action, environment and resource efficiency. Likewise, food waste reduction is another key issue in the framework of Horizon 2020, as described in Food security and sustainable agriculture and forestry challenge. Indeed, a large proportion of fresh produce is wasted during postharvest (25-50%) of horticultural crops, which is largely caused by dehydration. Therefore, this project deals with the urgent need of understanding factors influencing water loss to develop innovative solutions geared to saving water and reducing food waste. Based on the idea that cuticular waxes are critical for limiting water loss from fruit, and thus for resisting desiccation and spoilage, we propose to uncover the structural and regulatory pathways that mediate its biosynthesis, transport and assembly in response to drought stress through a multidisciplinary approach. Thus, SEM and TEM microscopy, GC/MS, as well as up-to-date technologies, such as Laser Capture Microdissection (LCM) and RNA sequencing, will be used. Tomato and citrus fruit will be selected as model systems to address this poorly understood area of plant biochemistry, physiology and molecular biology. The availability of mutants of both fruits, as well as the application of stress-related hormones during postharvest, will allow comparative surveys to better understand the regulation of these processes. The outcomes of this proposal will represent a major advance in the understanding of the crosslink between water stress, wax metabolism and fruit biology, and will suggest strategies for enhancing shelf life, drought hardiness and fruit quality in both climacteric and non-climacteric fruit.

Keywords: water stress,cuticle propierties,epicuticular wax,cutin,fruit quality,postharvest,tomato,citrus,ethylene,transcriptomic,rna sequencing,laser capture microdissection,desiccation
INTRASTEM: High Efficiency Delivery of Proteins, Nucleic Acids and Particles to Human Cells (INTRASTEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 147489.0
EU funding (EUR): 147489.0
Participants: 1
Project status: CLOSED

Under an ERC Advanced Grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in pluripotent stem cell culture as well as being applicable to many other mammalian cell types. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant funding has allowed exemplification of the delivery of proteins that promote pluripotency or differentiation, delivery and expression of mRNA and high yield delivery of nano and microparticles. This Proof-of-Concept Application will achieve 6 deliverables that together will generate a robust business plan for commercialisation of GET. We begin by performing, via a European marketing company, a comprehensive market analysis to test our view that GET could be used to replace lentiviral transfection, or as an in vivo reprogramming tool or for other challenngng pharmaceutical applications. Next we take account of the market analysis to refine our technical work resulting in a report that provides robust evidence of market required advantages of GET over competitor products. This technical work will include a consideration of manufacturing routes and costs of goods. In parallel with the technical work we will commission an independent freedom-to-operate report. Finally, we will initiate confidential discussions with potential partners and customers via face-to-face meetings in Europe and the US. The final business plan will establish the technical and commercial feasibility of our approaches in one or more of our target markets. We envisage that at the end of the ERC PoC grant we will attract substantial funding to rapidly progress product launches and licenses.

Keywords: regenerative medicine,intracellular delivery,protein therapeutics,nucleic acids,nanoparticles
Search for Axion-Like Particles at the LHC (LightAtLHC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1572500.0
EU funding (EUR): 1572500.0
Participants: 1
Project status: SIGNED

Axions and other very light axion-like particles (ALPs) appear in many extensions of the Standard Model and are well motivated theoretically: ALPs can solve the well-known strong CP problem, act as a dark matter candidate and could also explain the famous muon (g-2) discrepancy. The experimental effort to search for ALPs as dark matter candidates is ongoing and has been considerably intensified in recent years, leading to the proposal and construction of a wide range of dedicated experiments. However, none of these dedicated experiments is sensitive to those ALPs that can explain low-energy anomalies such as (g-2). I propose therefore to pioneer an alternative search strategy for axion-like particles via their decay into two photons, using data collected at the Large Hadron Collider. This approach requires fundamental innovations on the photon identification capabilities of the current detectors as well as radically new analysis strategies. Within the LightAtLHC project, I will study proton-proton and lead-lead collisions, collected during LHC Run-3, and search for Higgs Boson decays in two ALPs as well as the direct production of ALPs via photon fusion and their subsequent decay into two low-energy photons. To achieve the required sensitivity, I will develop highly specialized photon reconstruction algorithms for the ATLAS detector. These efforts will largely cover the relevant parameter space, leaving out only a small region. To also close this gap, I will extend the upcoming FASER experiment at the LHC by an innovative presampler detector, which allows for an unambiguous ALPs detection. By the end of the LightAtLHC project, I can either rule out the most promising ALP models in a mass range from 10 MeV to 1 TeV, or discover a new elementary particle.

Keywords: axion like particle,atlas
AXENIS Humanized Mice – Innovation towards industrial scale-up (HUMICE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: France
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Since 2010, AXENIS has developed proprietary, state-of-the-art humanized mouse models as preclinical tools for biomedical research and biopharmaceutical industry in the field of immunology, infectious diseases, immuno-oncology and inflammation. Humanised mice are extremely attractive and effective to perform a fine evaluation of new therapeutic and diagnostic options in a human-like environment. Overall, humanized mouse preclinical testing benefit to the patients (safer products) and pharmaceutical companies (upfront pre-clinical screening of molecules reducing clinical development costs). To become a global European leader addressing the health market needs for humanized mouse models, the humanized mouse production activity of the company requires to be scaled up to an industrial level that will better suit the end-users’ expectations. That is a reason why a feasibility study is needed to help AXENIS accessing a comprehensive survey of production scale-up (at least 10-fold) from current ‘low scale level’ (few hundred units per year) to the level of multiple of thousand units per year under optimal regulatory standards; an evaluation of the production costs with the aim of lowering the unit price by at least two; precise valuation of the demand market segments; and a risk assessment of the scale-up project. The HUMANMICE project is therefore the basis to the future development of the company, to establish humanized mice as a new standard for preclinical studies, develop the next generation of humanized mouse models, create an environment supporting business & collaboration opportunities, minimize the production costs and maximize the corresponding revenues.

Keywords: humanized mice,animal model,pre clinical,production scale up