Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Partial actions of monoids and partial reflections (PartAct)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-07
End date: 2021-01-06
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Mathematics is at the heart of many areas of research in the Sciences and Social Sciences, with new mathematical achievements feeding the growth of other areas. Most scientists are familiar with the notion of the algebraic construct of a group, and how groups may be used to encode and explore the notion of symmetry, by studying the way on which they act on various structures. However, much of the universe is not symmetric, and neither do we always have actions totally known or defined. In such situations it is monoids, and partial actions, that provide the correct mathematical paradigm. The overall aim of this project is to develop and apply two (related) sets of semigroup theoretical techniques for actions and partial actions. We have four sets of Objectives: Obj. 1. To determine when the partial action of a monoid M on a set X via partial bijections can be lifted to actions by bijections, and answer the corresponding question for inverse monoids. Obj. 2. To determine the conditions under which strong partial actions of monoids on sets with additional structure lift to actions on sets with the same structure. Obj. 3. To develop the theory of associative algebras and C*-algebras constructed from (partial) monoid actions. Obj.4. To determine the algebraic constituents and constructs associated to reflection monoids, in particular, to determine their congruences and ideals, and associated lattices. Each Objective is supported by a Work Package, each of which will take approximately 6 months, and result in a journal output. Our methodology, as usual in pure mathematics, is that of testing examples (including by computation), spotting patterns of behaviour, making and proving conjectures. A careful plan has been designed for the ER, weaving the academic objectives of the proposal with a 2 year programme of training and personal development in both skills and knowledge.

Keywords: action partial monoid semigroup reflection act
ALGAE4IBD –FROM NATURE TO BEDSIDE- ALGAE BASED BIO COMPOUND FOR PREVENTION AND TREATMENT OF INFLAMMATION, PAIN AND IBD (Algae4IBD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Italy,Germany,Israel,Norway,Slovakia,Belgium,Hungary,France,Czechia,Portugal
Call: Prospecting aquatic and terrestrial natural biological resources for biologically active compounds (H2020-FNR-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 7499520.01
EU funding (EUR): 7499517.25
Participants: 24
Project status: SIGNED

Algae4IBD's mission is to develop commercial products for Inflammatory Bowel Disease (IBD) prevention and treatment using aquatic natural biological resources. With the emerging developments in natural product, notable success has been achieved in discovering natural products and their synthetic structural analogues with anti-inflammatory activity. However, global biodiversity remains a largely unexploited resource for natural bioactive molecules with an enormous potential for developing commercial products with public health benefits. Micro and macroalgae, found in marine and freshwater, have been identified as promising sources of bioactive compounds including small molecules and secondary metabolites with a wide range of bioactivities as an antioxidant, anti-inflammatory and cancer preventive. Consumption of algae could, therefore, provide defence against chronic inflammatory diseases such as IBD, that until date have no effective cure. This project offers nature to bedside approach, using an entire development along the value chain for a new biodiscovery therapeutic approach by developing and examining algae-based compounds for IBD patients while guaranteeing algae's biodiversity preservation. We propose innovative solutions for increasing the use of algae-based ingredients and to ensure the science-based improvement of nutritional quality and its effect on public health. The researchers, companies and hospitals involved in the different stages of the project will use the biodiversity of algae, both micro and macro, as a wide source for bioactive compounds using state-of-the-art cultivation and extraction technologies for obtaining sufficient amounts of the bio-active molecules together with novel processing protocols. It will result in novel algal-based, high-quality bioactive compounds at GMP grade and lower costs for dual purposes – IBD prevention and treatment in relevance to the food as well as the pharmaceutical industries.

Keywords: microalgae,macroalgae,inflammatory bowel disease,microbiome,pain,functional food
A Novel and Affordable Multi-Fidelity Deep Neural Network Uncertainty Quantification/Robust Optimization Design Framework for Industrial Turbomachinery (MENTOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

This fellowship aims to train a talented early career researcher and to contribute to the EU scientific excellence by developing an innovative Multi-fidelity dEep neural Network uncerTainty quantificatiOn and Robust optimization design (MENTOR) framework in order to handle the high dimensionality (HD) uncertain problems in the advanced multistage turbomachinery design process. The applicant is a highly dedicated and motivated young researcher and has been stimulated to propose this novel idea. He has been successively honoured with several prestigious awards including the National Scholarship for PhD Candidate, Excellent PhD Graduates of Beijing, Excellent Doctoral Dissertations Award of Beijing and ASME Young Engineer Turbo Expo Travel Award attributed to his excellent research achievement in cost-efficient uncertainty quantification (UQ) studies. The traditional UQ methods can hardly control the computation cost for predicting the higher-order moments of multistage turbomachinery performance considering HD input uncertainties. The deep learning technology is a promising approximator in predicting the HD function. Integration of multi-fidelity (MF) methodology with deep neural network (DNN) can further combine their complementary merits. Thus, the novel MF-DNN method is proposed here and its effectiveness in handling a 60-dimensional test function has been preliminarily validated in the Incoming Researcher's recent work. Through this research fellowship, an affordable MENTOR framework will be finally established to investigate the multi-source uncertainty effects on multistage turbomachinery performance. This project has been carefully designed to match the applicant's profile with the strength of Imperial's UQ Lab, and thus will facilitate excellent two-way knowledge transfer and training activities. Successful completion of this fellowship will contribute to achieving the goal of the EU's "Green Deal" and will benefit the applicant's academic career prospect.

Keywords: turbomachinery aerodynamics,multistage axial compressors,uncertainty quantification,robust optimization design,multi fidelity approach,deep neural networks
Using comparative genomics to uncover the origins of phenotypic modularity in squamate reptiles (ULTRAMOD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The genomic determinants of morphological change are of great interest to evolutionary biologists, particularly how they relate to the loss and evolution of key traits. Ultraconserved elements (UCEs) are regions of genomes that are highly conserved across distantly related organisms. Many UCEs are located in cis-regulatory (enhancer) regions of the genome that play critical developmental roles in determining morphology; when UCEs are removed notable changes to the skulls and limbs of mammals can occur. These UCEs are highly conserved across vertebrates and the evolutionary loss of a single UCE (Sonic hedgehog limb enhancer) has been associated with partial and complete limb loss in squamate reptiles. However, much of what is known about the causal role UCEs play in development is derived from functional studies, which have only examined a handful of model species. A broader phylogenetic and genomic perspective of how UCEs relate to morphological variation would offer much needed information for interpreting the results of functional studies. Comparative genomics offers a means to dramatically increase the taxonomic sampling of UCEs, both through examination of annotated genomes and comparison of UCE loci obtained using sub-genomic sampling methodologies. I will use UCEs to characterize the enhancer landscapes of squamate reptiles that putatively underpin cranial and limb diversity. I will then relate the dynamics of these genomic landscapes to the modularity and integration of crania and limbs that occur across squamates using 3-dimensional (3D) scan data derived from museum specimens. This project will produce novel sub-genomic data and 3D scans that will be shared in online repositories. I will be aided by my hosts and their world-renowned museum collections to deliver this novel and cutting-edge project which will act as a springboard for my own independent research and teaching program.

Keywords: genome phenome analysis,comparative genomics,ultraconserved elements,enhancer regulatory regions,geometric morphometrics,squamata,reptiles
THE ROLE OF MUGINEIC ACID IN UPTAKE OF TRACE METALS IN PLANTS (MAZinc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-22
End date: 2024-11-21
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: SIGNED

Zinc (Zn) deficiency in agricultural soils is leading worldwide to the production of stunted rice and to human malnutrition. Some rice varieties take up Zn even if it is present in soil in low bioavailable amount, but the underlying process is unknown. One mechanism proposed includes the secretion of organic ligands (i.e. deoxymugineic acid-DMA), its complexation with Zn in soil and the uptake of the complex into the plant. Indirect evidence comes from isotopes studies but the direct proof (i.e. measure DMA secretion in soil and DMA complexation with Zn in competition with other cations) is missing. To this end, we will determine the fluxes of DMA secreted by roots. The challenges are to develop an experimental system that reproduces Zn deficiency in laboratory and to develop analytical methods that enable the identification and determination of the mass fluxes of DMA. We propose to use pot and hydroponic experiments with different Zn supply. The Zn deficiency in the soil/solution, will allow us to predict the stimulation of DMA production. The latest generation of LC-MS/MS with hugely improved sensitivity will be used to quantify the concentrations of DMA and Zn-DMA complexes. Moreover, we will establish an accurate stability series for Zn and other cations complexing with DMA and we will determine the reaction mechanisms and structure of Zn with DMA. The stability series will address the question of whether competition by other cations prevents the formation of the Zn-DMA complex in soil. Understanding the reaction mechanisms of Zn with DMA and establishing its structure will give invaluable insights into the stability of the complexes. We will achieve this conducting carefully designed laboratory and theoretical chemistry experiments. A prompt application of this research will enable plant breeders to select genes to enhance crop production in low Zn conditions.

Keywords: rice oryza sativa l,deoxymugineic acid dma,genotype nutrient uptake differences,solubilization,anaerobic soil,rhizospere
Microbe induced Resistance to Agricultural pests (MIRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Spain,Germany,Switzerland,France,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-12-01
End date: 2021-11-30
Duration (months): 48.0
Total project cost (EUR): 3936528.36
EU funding (EUR): 3936528.36
Participants: 11
Project status: CLOSED

Plants are intimately associated with a diversity of beneficial microorganisms in their root zone, some of which can enhance the plant’s resistance to insect pests. Thus, the use of Microbe-induced Resistance (MiR) to reduce pest losses in agriculture has emerged as a highly promising possibility to improve crop resilience and reduce use of harmful pesticides. European companies have therefore started to develop and market beneficial microbes. However, MiR appears to be strongly context-dependent, with reduced benefits under certain biotic and abiotic conditions and in some crop varieties. Further, it is a challenge to deliver and ensure stable associations of beneficial microbes and plants, and avoid undesired effects on beneficial insects. Thus we absolutely must improve our understanding of MiR mechanisms and context-dependency, in order to improve context stability of MiR and promote the use of MiR for crop protection. Our MiRA project will train 15 ESRs in basic and applied research on context-dependency of MiR, mechanisms, and impacts on plant performance and other biocontrol organisms. We will use this understanding to improve our ability to predict the effectiveness of MiR under different conditions, to select plant and microbial strains with improved context-stability, and to develop better methods for the formulation of microbial inoculants and their application in agriculture. Finally, we will analyse economic prospects and constraints for MiR development and use. To achieve these goals, we have assembled a consortium of 11 academic institutions and 6 companies, including microbial inoculant producers and agricultural advisors, with complementary skills in basic and applied research and innovation. Our ESRs will be trained within this multi-sectoral interdisciplinary network for a future career in research, product and service development in European horticulture and agriculture, pushing boundaries in European research and innovation.

Keywords: yield stability,integrated pest management,microbe induced resistance,plant defense,mycorrhiza,bacteria,herbivores,phytohormones,signaling networks,metabolomics,inoculants,tomato,potato
Questioning Traumatic Heritage: Spaces of Memory in Europe, Argentina, Colombia (SPEME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Argentina,Italy,Colombia,Netherlands
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-07-01
End date: 2024-04-30
Duration (months): 70.0
Total project cost (EUR): 553500.0
EU funding (EUR): 553500.0
Participants: 7
Project status: SIGNED

SPEME will develop a joint program of exchanges between academic researchers - working on memory, trauma and heritage - and non-academic professionals - working in the fields of memory museums and sites of memory - between Italy, The Netherlands, Argentina and Colombia. The fundamental aim of the project is to devise new forms of transmission of traumatic memories linking them to the present, on the assumption that memory, to be effective, has to invent creative ways of becoming relevant to the present. In order to do so, the project will take as its specific object of investigation a various array of spaces of memory, such as museums, former detention camps and sites of commemoration, to investigate how various traumatic pasts can be preserved and transmitted through space, and which kind of innovative actions might both improve knowledge of the past and serve as an opening to actual issues and new social subjects. The international and intersectoral network developed by the project will make possible transfers of knowledge, both between difficult past heritages in different historical and geographical contexts (Europe and Latin America) and between academic researchers and museum curators. The different and complementary competences of these institutions will promote something more than a simple knowledge transfer but will fuel powerful knowledge exchanges at the theoretical, methodological and practical levels, which has few or no precedents in the field of memory and museum studies. Through a rich combination of staff meetings, theoretical seminars, training workshops, fieldworks and conferences, this project will increase competences and skills of both academic and non academic partners, as well as facilitate the development of innovative and creative actions involving new social actors (civil society, new generations, minority groups, refugees, and others) and addressing actual questions, from Human Rights to post-conflict reconciliation.

Keywords: memory,museum,human rights,reconciliation,gender
The Tocharian Trek: A linguistic reconstruction of the migration of the Tocharians from Europe to China (TheTocharianTrek)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-12-31
Duration (months): 69.0
Total project cost (EUR): 1499980.0
EU funding (EUR): 1499980.0
Participants: 1
Project status: SIGNED

The long trek of the Tocharians from Europe to China is one of the most disputed issues in the migration history of Eurasia. Tocharian is an extinct branch of the Indo-European language family, which includes a.o. English, Latin, Greek and Sanskrit. The Indo-European languages stretch in one uninterrupted belt from Ireland to the Sea of Bengal, but Tocharian, discovered in manuscripts from the Tarim Basin in Northwest China dating from c. 500–1000 CE, is a notorious exception to this geographic distribution. The common ancestor of the Indo-European languages, Proto-Indo-European, can be hypothetically reconstructed and is often located in the east of present-day Ukraine. Therefore, speakers of early Tocharian must have made a long trek eastward before they settled in the Tarim Basin. Archaeological and genetic evidence suggests that they first moved east to southern Siberia around 3500 BCE and then south to the Tarim Basin in China, where they may have arrived as early as 2000 BCE. The arrival of the Tocharians in the Tarim Basin is possibly linked to ancient corpses found there: the so-called Tarim Mummies. Curiously, linguistic evidence has mostly been neglected. Therefore, the proposed project aims to provide an integrated linguistic assessment of the hypothesised migration route of the Tocharians. Languages preserve precious information about their prehistory through the effects of language contact. Through close scrutiny and periodisation of the different layers of contact of Tocharian and its prehistoric neighbours, the project will reconstruct the migration route of the Tocharians from the Proto-Indo-European homeland all the way to China. The crucial Siberian phase of the migration shows the groundbreaking nature of the approach. Genetic evidence points to influence from local Siberian populations on the early Tocharians. Likewise, the Tocharian language shows such heavy impact of local Siberian languages that this may be called the “birth of Tocharian”.

Keywords: language contact,indo european linguistics,tocharian,siberia,tarim basin