Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Decoding Peptide-Mediated mRNA Decay: Uncovering the Role of Nascent Polypeptides in Gene Regulation (DECODE-PMD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1703070.0
EU funding (EUR): 1703070.0
Participants: 1
Project status: SIGNED

Cells tightly regulate mRNA stability to ensure accurate gene expression across diverse cellular states and conditions. Traditionally, selective mRNA degradation has been attributed to the recognition of nucleotide sequence elements by proteins or small RNAs that subsequently recruit decay factors. Conversely, an emerging mechanism termed “peptide-mediated mRNA decay” (PMD) involves the encoded protein: my postdoctoral work revealed how the nascent polypeptide—physically linked to the mRNA during translation by the ribosome—can direct mRNA decay. This process is exemplified by tubulin mRNAs, which are selectively degraded when cells sense excess free tubulin levels. In this novel type of regulation, a recognition factor binds the nascent polypeptide to recruit downstream factors that trigger mRNA degradation. Impaired tubulin PMD results in severe phenotypes like defects in cell division and neurodevelopment. Beyond tubulins, emerging evidence points to critical PMD mechanisms targeting transcripts encoding aggregation-prone proteins. I postulate that PMD represents an entirely unexplored paradigm of gene regulation that dynamically adjusts protein production to ensure cellular fitness. However, the mechanistic understanding of PMD is still limited and the full range of substrates remains unknown. In DECODE-PMD I will unravel how nascent polypeptides direct mRNA degradation on ribosomes and chart the transcriptome-wide map of PMD substrates. Specifically, I aim to (1) decode how mRNA translation and degradation are coupled during tubulin PMD using a biochemical reconstitution approach; (2) decipher the physiological triggers of tubulin PMD and its regulation; and (3) harness advanced sequencing methods to systematically identify PMD substrates and derive common mechanistic principles. Our innovative work will provide a conceptual framework for how cells exploit nascent polypeptide recognition for selective tuning of mRNA stability to maintain protein homeostasis.

Keywords: rna degradation protein synthesis ribosome gene regulation transcriptomics structural biology microtubules cytoskeleton cell cycle
Rural Environmental Monitoring via ultra wide-ARea networKs And distriButed federated Learning (REMARKABLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal,Serbia,Rwanda,South Africa,Nigeria,United Kingdom,Spain,France,Morocco,Greece
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1275514.29
EU funding (EUR): 1145400.0
Participants: 18
Project status: SIGNED

Internet of Things (IoT) technology combined with complementary support for data analytics is the corner stone of today's digital transformation. The societal and economic impact of IoT/ML systems in urban and suburban areas significantly outpaces the one in rural areas due to a limited reach of connectivity infrastructure. To reverse further widening of the urban-rural gap, we need to bring efficient and affordable IoT/ML solutions to deep rural areas, reaching out to applications and use cases ranging from wildlife management, rural tourism, livestock monitoring, water and air pollution control, and others. By identifying main gaps in connectivity and affordable data analytics and through interleaved research, development and validation in a real-world setting, REMARKABLE will address the challenge of bringing IoT and data analytics systems a step closer to seamless, energy efficient and secure deployment in rural ares. The consortium composed of six European academic partners, five companies and five associated partners representing leading academic groups from Africa, will focus on research, development, innovation and demonstration across five use cases with six demonstration sites located in rural areas across the European and African continent. The inter-disciplinary nature of the programme provides a unique opportunity for investigation of smart sensing, IoT and data science technology from non-traditional, holistic perspectives leading to new scientific achievements and innovations. Project outputs like smart IoT sensors and devices, rural IoT digital twining platforms, ultra wide-area IoT networks, novel data analytics models and architectures will find their routes to the market via active industrial partners. The project will impact EU workforce market via new interdisciplinary skills for young contributors and form new long-lasting networks of European and African institutions in the area of sensing, IoT, big data analytics and rural entrepreneurship.
Fimuskraft Biogas Plant (FKBP): a revolutionary and cost-effective biotechnological method to treat and valorise biowaste (FKBP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 3432125.0
EU funding (EUR): 2402487.0
Participants: 1
Project status: SUSPENDED

Anaerobic digestion (AD) for the treatment of organic wastes has been hailed as a green and sustainable technology. However, AD adoption is still hindered by various limitations. E.g. AD plants are applied for centralised waste management with production of pathogenic and low quality digestates, usually landfilled, leading to no waste valorisation. AD plants produce biogas of low yield and energetic potential. In addition, they are significant capital investments with a long payback. To solve these pains, FimusKraft have developed the FKBP, a system which elegantly combines (a) bio-gas fermentation with an (b) innovative biowaste enzymatic pre-handling process and (c) microturbine with gas analysis and control system. The FKBP is compact and modular and able to simultaneously treat various types of biowaste to produce electricity, heat and high quality ecological organic fertilizer. The FKBP is the first biogas plant able to produce higher energetic biogas (up to 97% CH4/H2 mix).

Keywords: food and beverage,sustainability,biorefinery,circular economy,enzymes,pollution mitigation,climate change,biofertilizers,bioenergy,bio fermentation,biowaste
Deformable concrete composites for durable infrastructure (DefCrete)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Current infrastructure elements requiring controlled deformation, such as tunnel support systems and bridge expansion joints, predominantly rely on steel components that face significant durability challenges due to corrosion. This project advances an innovative solution through auxetic cementitious composites (ACC) - a novel class of materials combining 3D-printed thermoplastic polyurethane (TPU) auxetic frames with cementitious mortar. Initial laboratory testing has demonstrated remarkable properties, including compressive strains up to 40% and highly recoverable deformation under cyclic loading (up to 10% strain). Building on breakthrough findings from an ERC Starting Grant, this Proof of Concept project will advance the technology from TRL 2-3 to TRL 4 through four key activities: numerical modelling for design optimization, cyclic performance characterization, manufacturing scale-up, and market validation. The project will establish manufacturing protocols for larger-scale elements (decimetre size), validate performance under application-relevant conditions, and develop a comprehensive commercialization strategy. The innovation addresses a clear market need by eliminating corrosion concerns while providing superior mechanical performance. The technology's unique combination of controlled deformation capacity and durability opens possibilities for multiple infrastructure applications beyond initial target markets. The project will engage key stakeholders including infrastructure owners, engineering consultants, and manufacturers to validate requirements and identify pilot opportunities. Successful completion will establish the foundation for scale-up through subsequent funding (EIC Transition), leading to pilot demonstrations and market entry. The technology offers significant potential for reducing infrastructure maintenance costs while improving performance and reliability of critical deformable elements.
Europractice 2.0 (Europractice2.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Coordination and support actions
Partnership: CHIPS (JU-JTI)
Countries involved: Belgium,United Kingdom,Germany,France,Ireland
Call: A Pan-European infrastructure for Chips Design Innovation (HORIZON-JU-Chips-2025-CSA-1, 2025)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 11993182.5
EU funding (EUR): 11993182.5
Participants: 5
Project status: SIGNED

The Europractice 2.0 project will provide Europe with a robust infrastructure for chip design innovation from day one. It will build on 30 years of evolution of renowned Europractice services, consolidating and extending them to offer users an affordable, open-access framework for designing and fabricating chips. The primary goal will be to lower the entry barriers for universities, research institutes, and their spinouts by providing affordable access to industry-standard design tools, fabrication technologies, and comprehensive training. This will be complemented with extensive customer support covering technical and operational aspects. Europractice 2.0 will immediately deliver impact by supporting 600 universities and research institutes annually with affordable design tools. The project will facilitate design IP exchange between users to expedite the design process. The project will offer fabrication services in 90 technologies from various suppliers based on the cost-sharing multi-project wafer (MPW) principle, complemented by packaging and heterogeneous integration techniques. The portfolio will be continuously updated with advanced and emerging technologies from European research centres and Chips JU pilot lines. To address the semiconductor skills gap, Europractice 2.0 will train over 650 participants annually, increasing the impact through a train-the-trainer initiative. Simplified design flows and shared tapeouts for ClassIC student chips will further lower entry barriers and expand hands-on learning. Europractice 2.0 will also play a key role in nurturing academic spinouts during their incubation phase. Close collaboration with the EU Chips Design Platform will ensure a seamless transition to acceleration and commercialisation, creating a clear, structured path from research to market and contributing to the long-term growth and resilience of Europe’s semiconductor ecosystem

Keywords: semiconductor,chips design,multi project wafer,prototyping,skills development,ip exchange,heterogenous integration,proof of concept,european academia,research and innovation,academic spinouts
Dynaes 50 for very low GWP refrigerants (DYVELOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: SIGNED

The major challenges in today's world, like high energy consumption by humans for daily use and the pressing need to reduce carbon footprints, underscore the critical importance of efficient thermodynamic systems. According to the IEA, the building sector contributes to 28% of the energy sector emissions out of which, approximately 50% of the total energy consumption in buildings is due to HVACR (Heating, Ventilation, Air Conditioning, Refrigeration) systems. Dynaes addresses these challenges head-on with its passive device technology, seamlessly integrated into HVACR systems, enhancing their energy efficiency even in extreme temperatures. The technology boasts energy savings in the 30% - 70% range, alongside a huge potential to reduce global CO2 emissions by 7%. These advantages translate into large cost savings for customers, making Dynaes an attractive option for businesses and individuals seeking to minimize operational costs and enhance sustainability efforts. Key to this innovation is the mixture of the refrigerant and the lubricating oil, optimized to maximize heating or cooling capacity without increasing compressor power consumption. With three granted patents and unparalleled expertise, Dynaes is poised to revolutionize the thermodynamic systems landscape by licensing its technology to systems and components manufacturers. The DYVELOR project aims at optimizing Dynaes 50 for refrigerants with very low Global Warming Power, like propane for example. The EU regulator is indeed pushing for this type of refrigerant because, in the unlikely case of a leak in the atmosphere, it has a low greenhouse effect. This is clearly a strong trend in the EU and it is expected that other regions will soon follow. While the project presents technological risks, securing EIC funding is essential for Dynaes to mitigate these risks, optimize the technology, and conduct testing with partners to bring it to TRL8. In parallel, Dynaes will initiate business development in Europe.

Keywords: hvacr systems,co2 emission reductions
GALVANI Scalable Workflow Innovation for Focal tES Therapy (GALVANI SWIFT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The ERC Galvani project aims to revolutionize transcranial electrical brain stimulation (tES) therapy for epilepsy through a computational breakthrough. By combining the expertise of clinical researchers and computational neuroscientists, the project will develop personalized brain stimulation solutions integrating magnetic resonance imaging (MRI) and stereoelectroencephalography (SEEG) data into advanced brain models. Neuroelectrics, a leader in medical neurotechnology, is implementing these solutions in a pipeline that transforms patient data into individualized brain models and optimized tES protocols in focal epilepsy. However, algorithms are highly dependent on the availability of high-quality MRI data and require time-consuming manual processing. Clinical translation at scale faces two key challenges: first, image head cropping and uneven data quality in MRI scans, and second, brain lesions, which deviate from normal anatomy and require manual segmentation by trained operators. These result in a more complex, time-consuming, and costly personalization process. To overcome these obstacles on the path from ground-breaking research to innovation, the SWIFT project introduces an AI-based deep learning approach that enhances MRI data quality and automates the handling of anatomical alterations, such as brain lesions, improving model accuracy and reducing processing time. To ensure translation into innovation, the project will develop a business strategy that addresses productization, regulatory, intellectual property, and commercialization challenges toward the goal of making model-driven tES therapy more scalable, cost-effective, and accessible to a broader range of epilepsy patients.
Deep eutectic solvents for membrane transport of nucleic acids (DUNE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The delivery of nucleic acids as therapeutic methods holds great potential to provide new treatments against emergent pathogens and important diseases. However, the development of functional therapies is often hindered by the poor efficiency and stability of the current transport technologies. Deep eutectic solvents (DES) are non-aqueous sustainable liquids obtained through the combination of simple organic molecules. The physicochemical properties of the DES can be tailored through the selection of their constituents, to optimally perform in specific applications. DES have been recently shown to increase the stability and activity of nucleic acids (NA), as compared to those in aqueous systems. Despite the excellent and encouraging physicochemical properties of DES, these solvents have not been investigated, to date, for the transport of NA across cell membranes. This project will finally fill the knowledge gap that exists between the promising properties of DES and their potential ability to selectively deliver NA into the cell cytosol. Here, a combinatorial approach will be used to synthesise a library of DES with different properties relevant for transport (e.g., amphiphilicity and charge density). The ability of these to enable membrane transport of NA will be investigated as a function of the system properties. The exclusive properties of the DES solvent will go beyond the state-of-the-art, as they will allow: i) fine-tuning of DES/cargo interactions and binding strength by DES counterion adjustment; ii) precise hydrophobic DES control for membrane partition regulation; iii) enhanced physicochemical stability of the resulting particles and simpler synthetic and scaling up methodology, as well as reduced production costs. Overall, this project is aimed to discover a completely new range of potential applications of DES in membrane transport and biomolecular cargo preservation, which will open a new research field of potential applications in NA delivery.

Keywords: deep eutectic solvents,nucleic acid transport,membrane transport,soft nanoparticles
Framework to IMPROVE the Integration of Patient Generated Health Data to Facilitate Value Based Healthcare (IMPROVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Spain,Denmark,Switzerland,Slovenia,Netherlands,Germany,Italy,Austria,Greece
Call: Patient-generated evidence to improve outcomes, support decision making, and accelerate innovation (HORIZON-JU-IHI-2022-03-single-stage, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 17115898.05
EU funding (EUR): 10313760.5
Participants: 28
Project status: SIGNED

IMPROVE will use Patient Generated Health Data (PGHD) gathered via m-health and e-health technologies to gain improved insights into the real-life behavior of, and challenges faced by, patients of all ages with complex, chronic diseases and comorbidities. Already today, a wealth of patient and citizen information is available, but fragmented, and therefore not coming to its full utility and value. These personal data will complement and improve existing approaches for Patient-Centered Outcome Measures beyond those currently available in state-of-the-art platforms. The IMPROVE platform that the consortium will build will enable the smart use of patient input and patient generated evidence to 1) advance the role of patient preference and patient experience in the context of treatment selection, 2) improve medical device design based on patient preferences and experiences, and 3) facilitate faster market entry of patient-centric and cost-effective advanced integrated care solutions. Improved clinical adoption of Value Based Health Care, and enhanced return on research and innovation investments will be demonstrated in different care settings across the EU, for 10 use cases in at least 5 different disease areas (e.g., ophthalmology, oncology, cardiovascular disease, chronic inflammation, and neurology). The use cases will be conducted using a large variety of implementation strategies, building on a design thinking approach, to optimally test the innovative framework of data gathering and translation into controlled change and action. In addition, a significant contribution from implementation science is planned to reach out to all stakeholders that are relevant for this initiative and maximise the impact to IMPROVE healthcare provision.

Keywords: patient generated health data use cases framework smart integrated healthcare