Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel techniques for quantitative behaviour of convection-diffusion equations (techFRONT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Physical laws are mathematically encoded into partial differential equations (PDEs). They tell us how certain quantities---like heat, water, or even cars---depend on position and time. Even without knowing the solutions explicitly, the ultimate goal of this project is to investigate fine properties of irregular solutions of certain classes of PDEs: can we predict the behaviour of the solution by using barriers; how will the solution behave after a long time has passed; can irregular solutions become regular---possibly classical; are the problems well-posed even for growing initial data? In practice, such properties describe the underlying physical model. Indeed, the mathematical insight provides new knowledge about the real-world applications, and information about the application gives hints to solutions of mathematical problems. We aim to use new and innovative techniques to prove fine properties of solutions of generalized porous medium equations (GPME). We intend to build a solution theory for a new class of weak solutions. This includes general well-posedness, regularity theory, and asymptotic behaviour. Our approach will provide an alternative to established methods due to DeGiorgi-Nash and Moser which seems to be unsuitable in this context. When there is convection present in GPME, that is, when we have a convection-diffusion equation (CDE), we plan to explore the possibilities of using the new to theory for GPME to shed new light on the asymptotic behaviour for CDE.

Keywords: generalized porous medium equations,convection diffusion equations,well posedness,regularity,asymptotic behaviour,bounded and growing initial data
Visualising age- and cataract-related changed within cell membranes of human eye lens using molecular rotors (Cata-rotors)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The lens of a mammalian eye is a unique tissue, which maintains high transparency during an individual lifespan, yet has no protein and lipid turnover. Thus, the eye lens is considered as one of ideal models of human aging. With age the proteins and lipids of the lens accumulate numerous post-translational modifications, leading to defects in the cell membrane structure and, therefore, to impairments of metabolite transport. The retarding of the metabolite exchange predisposes the lens nucleus to oxidative stress – a key factor in the formation of cataracts. Therefore, a study of the normal functioning of the lens, as well as age- and cataract-related changes in metabolite transport through the lens cells may shed light on the general mechanism of the lens aging and cataractogenesis. The present project is aimed at investigating and directly quantifying age- and cataract-related changes in the properties of cell membranes of the human eye lens by Fluorescence Lifetime Imaging Microscopy (FLIM), employing fluorescent viscosity-sensitive probes termed ‘molecular rotors’. We envisage that the results obtained will show the distribution of viscosity within membranes of fibre cells and will allow to directly visualise how the age and the early stages of cataract influence on fluidity of these lipid bilayers, which are of vital importance in maintaining the clarity of our eye lens and our vision. Analysis of age-related changes in the structure of membrane proteins and experiments with animal eye lenses subjected to photo-oxidation and chemical oxidation will provide additional information on the mechanisms of age- and cataract-related changes in viscosity within lens fibre cell membranes. Overall, this project addresses issues of fundamental importance in biophysics, as well as provides underpinning knowledge for understanding of health and disease and the treatment of an important eye condition: cataract.

Keywords: fluorescence lifetime imaging microscopy,molecular rotors,human eye lens,cataract,fibre cell,membranes,viscosity,lipid order,membrane proteins
Making better runners & cross-country skiers by real-time AI coaching (Racefox)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2021-08-31
Duration (months): 30.0
Total project cost (EUR): 2655268.75
EU funding (EUR): 1858688.13
Participants: 1
Project status: SIGNED

Wememove is a Swedish SME led by Magnus Jonsson, a successful serial entrepreneur, and Christer Norström, a PhD and a former CEO of the Swedish Institute of Computer Science. Wememove has designed and brought to TRL6 Racefox—an artificial intelligence-based personal training coach for cross-country skiers and runners. Wememove has won funding from the Swedish Innovation Agency Vinnova to conduct a feasibility study and was placed on the NyTeknik 33 list of most innovative Swedish companies in 2016, 2017 and 2018. Racefox is a combination of a special wearable device worn across the chest, a smartphone app and a series of AI algorithms that analyze the position of an athlete’s body in space and give real-time feedback on how to improve his/her skiing or running technique and prevent injuries. Racefox is backed up by large amounts of motion data collected both from individuals training and performing in races & competitions. Racefox will disrupt the personal coaching market by introducing a high-quality, low-price digital AI coach. By September 2018 Wememove has sold 4.300 Racefox devices and became the first official digital coach of Vasaloppet—the biggest cross-country skiing race in the world featuring 70,000 participants annually. Wememove has secured a series of strategic partnerships with competitions and races globally to develop dedicated training packs. Wememove is also working with Capio—a large medical organization—to create injury recovery packs to be used by sports practitioners. For this 24-month Phase 2 project Wememove is requesting a €1.85M contribution to bring Racefox to market, develop additional training functionality and complete injury prevention modules, validate it in several major cross-country skiing and running competitions and prepare for the large-scale market introduction.

Keywords: sport,training,digital coach
Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure (Titin Signals)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-07-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 3
Project status: CLOSED

Chronic heart failure is a leading cause of mortality in the industrialized countries. Pathomechanistically, a variety of diverse stress signals on the cardiomyocyte trigger loss of myofibrils and cardiomyocyte death, thereby activating a vicious cycle of cardiac stress and deterioration during terminal heart failure. Despite the enormous clinical relevance, the exact pathomechanisms in charge remains unclear. Here, I propose to investigate the molecular mechanisms that couple mechanical cardiomyocyte strain and cardiomyocyte loss during the heart failure involving the mechanosensing titin filament. For this, I will perform research in three globally leading teams and access their complementary expertise in a secondment scheme. In the the proposed 2-year outgoing phase, I will study how cardioprotection is mediated by key factors recently identified in the Ju Chen lab (UCSD, San Diego). During this time, I will be trained in cutting-edge molecular mouse genetic models and phenotyping tools. This research is expected to shed light on CARP-titinsignaling axis in cardiomyocyte death and to provide tools for manipulating this pathway. In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules. Taken together, this work encompasses structural studies at the atomic level up to vivo animal models to study CARP-titin functions. After the propose three years, I expect to be ready to pursue an independent career in the field of molecular cardiology research. Therefore, my goal during the re-integration phase will be to set-up an interdisciplinary collaboration involving the three lead teams of this proposal.

Keywords: heart failure,cardiomyocyte,titin,ankrd1,carp,mechanoptosis,transgenic mouse models,structural biology
Multimodal, Functional Bio-Photonic Imaging (FBI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Austria,Switzerland,Lithuania,France,Netherlands,Netherlands,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-10-01
End date: 2021-03-31
Duration (months): 54.0
Total project cost (EUR): 3902716.44
EU funding (EUR): 3902716.44
Participants: 15
Project status: CLOSED

FBI fosters education of ESRs on an emerging, multimodal imaging platform and its translation into clinical and biological applications. In FBI, 15 ESRs are trained at world-leading European academic institutions and companies, thus forming strong interdisciplinary relations between industry, technical sciences and clinical end-users. Optical imaging has huge potential to address unmet clinical needs by combining non-invasive and real-time capture of biomedical information; thus enabling earlier onset of treatment, reduced therapy costs, reduced recurrence rates, and improved clinical outcomes. Up to now, optical modalities were applied as standalone techniques each targeting one biomarker. Recently it has been shown that diagnosis is significantly improved by combining different contrast mechanisms simultaneously in a multimodal approach, i.e., staging and grading of lesions is feasible. FBI proposes to combine a selection of modalities depending on the targeted disease. Suspicious lesions are analysed with optical coherence tomography, optoacoustic tomography, multi-photon tomography, and Raman spectroscopy to provide morphological, label-free microangiography, and intrinsic biochemical information, respectively. An important issue is the need for endoscopy: combining said modalities into endoscopes is challenging due to the integration of different imaging concepts, scanning and detection methods, and laser sources. Accordingly, there is a huge need for effectively translating these technical solutions to industry and clinics, which traditionally is restricted by lack of understanding of applications or limited knowledge of new technology. All these barriers are addressed by FBI through research and development of novel photonic components and systems, through educating ESRs in understanding clinical, biological and commercial challenges, and through developing tailored technical solutions and efficient translation of technology within a strong network.

Keywords: multimodal functional imaging,biophotonics,light sources for biomedical,clinical applications,optical non invasive imaging systems for clinical and biological applications
Non-elected politics. Cure or Curse for the Crisis of Representative Democracy? (CUREORCURSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2025-02-28
Duration (months): 78.0
Total project cost (EUR): 1981589.0
EU funding (EUR): 1981589.0
Participants: 1
Project status: SIGNED

Evidence of a growing disengagement of citizens from politics is multiplying. Electoral turnout reaches historically low levels. Anti-establishment and populist parties are on the rise. Fewer and fewer Europeans trust their representative institutions. In response, we have observed a multiplication of institutional reforms aimed at revitalizing representative democracy. Two in particular stand out: the delegation of some political decision-making powers to (1) selected citizens and to (2) selected experts. But there is a paradox in attempting to cure the crisis of representative democracy by introducing such reforms. In representative democracy, control over political decision-making is vested in elected representatives. Delegating political decision-making to selected experts/citizens is at odds with this definition. It empowers the non-elected. If these reforms show that politics could work without elected officials, could we really expect that citizens’ support for representative democracy would be boosted and that citizens would re-engage with representative politics? In that sense, would it be a cure for the crisis of representative democracy, or rather a curse? Our central hypothesis is that there is no universal and univocal healing (or harming) effect of non-elected politics on support for representative democracy. In order to verify it, I propose to collect data across Europe on three elements: (1) a detailed study of the preferences of Europeans on how democracy should work and on institutional reforms towards non-elected politics, (2) a comprehensive inventory of all actual cases of empowerment of citizens and experts implemented across Europe since 2000, and (3) an analysis of the impact of exposure to non-elected politics on citizens’ attitudes towards representative democracy. An innovative combination of online survey experiments and of panel surveys will be used to answer this topical research question with far-reaching societal implication.

Keywords: democracy,representative democracy,institutions,deliberative democracy,participatory democracy,reforms,citizens,political support,experts,political trust,surveys
The triboreactor as breakthrough remediation strategy for safeguarding human and environmental health (triboREMEDY)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Spain,Spain,Belgium,Belgium,Sweden
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-03-01
End date: 2023-05-31
Duration (months): 51.0
Total project cost (EUR): 2831993.75
EU funding (EUR): 2831993.75
Participants: 7
Project status: SIGNED

Environmental remediation for safeguarding human health is difficult. Effective processes enabling scalable operability are lacking. triboREMEDY aims at solving this impasse by providing the foundational steps towards the novel technology called “tribolysis” for safe, controlled, and efficient degradation of hazardous chemicals and effective inactivation of the pathogens. The scientific and technological breakthrough of triboREMEDY is based on the generation of nascent surfaces, high pressures, and shearing forces that will supply the required activation energy for dissociation of polychlorinated biphenyls (PCBs) and cell disintegration of pathogens. The centrepiece of triboREMEDY is the fully-controlled “triboreactor” in which mechanically (tribologically) induced chemical reactions take place as viable alternative to A) highly costly incineration or storage of hazardous waste, notably PCBs, and B) chemical, thermal inactivation or ultra-violet irradiation of pathogens in drinking water. The main project aim is to set scalable design rules for the “triboreactor” (proof of concept) based on the identification of PCB degradation products and pathogen inactivation pathways together with their relationships to operational parameters. In addition to this, the long-term vision beyond halogen elimination of PCBs and disinfection of drinking water avoiding chlorine treatments, will cover other toxic organic chemicals, application in chemical synthesis, catalysis free of critical raw materials, coating processes, requiring sensors for the monitoring of trace components, opening a wide new scientific and technological field. triboREMEDY will be driven by a multidisciplinary team of excellent researchers in mechanical engineering, chemistry, physics, biology, and medicine enabling the required unique breakthrough and interdisciplinary approach. In last FETOPEN call, triboREMEDY reached score 4.15/5.00 and the suggestion of evaluators were considered for this new application.
How Institutions Shape Culture: Survey and Experimental Evidence from a Large-Scale Land Tenure Reform Implemented as a Randomized Control Trial (MYlandOURland)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This project aims to isolate the causal effects of formal institutions (mainly, laws and regulations) on cultural variables that influence economic development, such as trust, cooperation, social value orientation, competitiveness, thriftiness, and work ethics, in order to better understand how to design institutions that facilitate market exchange. The applicant will conduct surveys and lab-in-the-field experiments to collect data on these cultural variables in several villages in Benin, West Africa, where a major reform consisting in the formalization of property rights over land was implemented in hundreds of rural villages between 2006 and 2011. The effects of this institutional reform on culture will be estimated by comparing data collected in villages affected by the reform with data from villages where no land rights formalization took place. Identification is based on the randomization process characterizing the selection of villages where the reform took place: the project studies the first – and so far unique – case of land tenure reform implemented as a large-scale randomized control-trial. Given the unique identification strategy that overcomes most of the limitations characterizing previous studies, the use of state-of-the-art methodologies, and an interdisciplinary approach investigating the problem through the prism of gender equality, results will determine important advances in the existing knowledge regarding the optimal design of institutions. These outcomes will directly benefit low- and medium-income countries that are implementing land tenure reforms by suggesting ways to improve the design of new institutions. Furthermore, important benefits deriving from this project will be shared also by western societies, since findings will improve the effectiveness of the resources invested in development aids, and since the results will advance existing knowledge regarding the process and consequences of institutional change.

Keywords: institutions,institutional change,lab in the field experiments,land tenure reforms,land titling,law and economics,property rights
Trapping airborne particles by Jumping-droplet condensation on superhydrophobic surface (TrapJump)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Inhalation of microscale particles can cause severe health issues in respiratory and cardiovascular systems of humans. Trapping airborne particles by water droplets is one of the most widely used methods to reduce the particle concentration in polluted air. However, generating intensive micro-droplets via spraying or ultrasonic atomization normally requires specialized equipment and a large amount of energy. In this project, I propose a novel and cost-effective approach to capture particles by utilizing abundant self-jumping droplets generated during condensation on a superhydrophobic surface. Since the condensation process is ubiquitous and can be found in various heat transfer devices such as air conditioners, the proposed strategy will significantly reduce the expenses and energy costs for particle removal. In particular, to enhance the particle trapping rate, I intend to explore the rational superhydrophobic surface topography that allows continuous jumping-droplet condensation. I will first analyze the condensing droplet wetting dynamics using the cutting-edge confocal microscopy developed by the host lab. The results obtained will help to optimize the surface structures to achieve the durable condensate repellency. Next, I will investigate the effects of jumping droplet characteristics on the particle-droplet interaction from a single-droplet perspective. Finally, I will use my expertise in thermal physics to quantitatively correlate global condensation heat transfer and particle trapping performance. By integrating these interdisciplinary studies, the project will make a conceptual breakthrough in mitigating air pollution without additional energy consumption, and pave the way for the next-generation climate control devices with built-in air purification capabilities.

Keywords: superhydrophobic,wetting,condensation,aerosol,air quality control