Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early-life stressors and LifeCycle health (LIFECYCLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Australia,Spain,Germany,Finland,Greece,Norway,Finland,France,France,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Networking and optimising the use of population and patient cohorts at EU level (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 10414945.84
EU funding (EUR): 9957602.09
Participants: 19
Project status: SIGNED

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the EuroCHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies. LIFECYCLE will enrich this EuroCHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LIFECYCLE will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life. To strengthen this long-term collaboration, LIFECYCLE will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies. Ultimately, LIFECYCLE will lead to a unique sustainable EuroCHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.

Keywords: fetal origins,life course,programming,pregnancy,childhood,population based
EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts (EDIReX)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Spain,Austria,Germany,Spain,Italy,Norway,Belgium,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2017-1-two-stage, 2017)
Start date: 2018-02-01
End date: 2022-07-31
Duration (months): 54.0
Total project cost (EUR): 5156198.75
EU funding (EUR): 5156198.75
Participants: 20
Project status: CLOSED

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.

Keywords: preclinical and translational oncology,xenograft,biobank,joint management of distributed infrastructure,standards,repository,trans national access,research,dissemination,training
Design of a new non-existing layer of information delivery through smell (OWidgets)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-02-01
End date: 2018-01-31
Duration (months): 12.0
Total project cost (EUR): 149903.0
EU funding (EUR): 149903.0
Participants: 1
Project status: CLOSED

The idea for this proposal is to demonstrate the design of olfactory widgets (OWidgets) as a proof-of-concept implementation based on the semantic integration of smell to convey specific information to the user. We will showcase the meaningful design of OWidgets in two distinct markets. Widgets are well established as simple application extensions, integrated in a larger application and usually pre-installed on a device. Widgets allow quick access to information without requiring a user to open the application that manages this information. OWidgets will expand the existing range of widgets and provide users with a new non-existing layer of information delivery through smell, and consequently allow the creation of novel experiences in various application contexts.

Keywords: human computer interaction,smell as interaction modality
The International Criminal Court and the Judicial Function: a Socio-Legal Study of Judicial Perceptions and Practices (INCRICO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-07-02
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

INCRICO investigates the ways in which the International Criminal Court (ICC) perceives its judicial function and how this impacts its legal practices. The overall goal is to offer a realistic account of the international criminal judiciary with regard to judicial deliberations, reasoning and drafting judgments. To meet this objective, INCRICO aims to tackle the topic using a unique interdisciplinary approach, employing doctrinal legal analysis as well as contemporary sociology of law for explaining international criminal law and international criminal courts and their link to global society. The project’s specific objectives are to: (1) gather, analyse and collate international legal data and sources relevant for determining the content, scope, nature and practice of the ICC’s judicial function, as well as the relevant body of the ICC’s case law/jurisprudence/applicable law, including dissenting and individual/separate opinions; (2) gather (through in-depth interviews with the ICC's judges) and analyse qualitative data on the judges’ perceptions and understanding of their judicial function, in terms of what and how the judges really think, and what they are doing and why, so as to identify the judges’ view and experience at the ICC and how this correlated to the case law of the Court; (3) integrate legal assessment of dissents/case law/jurisprudence of the ICC with the judges’ accounts to map out and critically analyse the ICC’s judicial function; (4) increase awareness and knowledge of the ICC’s judicial function among relevant scientific and criminal justice management/policy making communities, and the general public. INCRICO is involving an excellent academic and interdisciplinary environment at iCourts where the researcher will spend the entire period. This is a unique proposal which targets growing concerns on legitimacy, effectiveness, independence and fairness of global criminal judiciary. Thus, it fits perfectly with the goals of the IF and Horizon 2020.

Keywords: international criminal court,judicial function,international criminal judges,judicial deliberations,reasoning,judicial perceptions,practices,international sociology of law,qualitative interviews
Innovative EASA certified dynamic test method for 16g aircraft seat cushions (16gAirTest-Phase2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2016-01-01
End date: 2018-06-30
Duration (months): 30.0
Total project cost (EUR): 1845893.75
EU funding (EUR): 1280925.63
Participants: 1
Project status: CLOSED

Airplane seat cushions are designed to be safe, comfortable, supportive for passengers' legs and backs, and lightweight to save fuel and CO2 emissions. But how many times did you experience worn out, uncomfortable cushions, too hard on legs and back? This happens because seat cushions should be replaced every 4-5 years, to maintain their safety and comfort characteristics. But cushions replacement is expensive: a cushions set may cost 600 € and, when original replacements are no more in production the whole seat must be replaced (~1.300 €/pax). In fact cushions need to be certified along with the seat, through expensive crash tests. So airlines delay cushions replacements and passengers travel on unsafe and uncomfortable seats. Testori Aero Supply (TAS) has found a way to overcome this deadlock: it has developed a test method for 16g monolithic models that certifies cushions only, independently from the crash test on the whole seat. This method has been approved by European Aviation Safety Authority (EASA). TAS is the unique company able to sell alternative 16g certified monolithic cushions, at an extremely competitive price (160 €/pax). This project intends to extend this certification method (and obtain EASA/FAA approval) to a new type of airplane cushions, the 16g multilayer, that have been recently introduced in the market by Original Manufacturers (OEM) to increase passenger's comfort and lower weight. Grace to this method TAS will produce and commercialize certified 16g multilayer cushion replacements, at an average sale price of 240 €/pax, thus becoming de-facto the only authorized competitor of OEM. The feasibility study conducted in SME action Phase 1 has assessed the project feasibility, costs and impacts on the company and on other SMEs of the production chain, and has outlined a business scenario where TAS will more than double its turnover by 2020 (+160%), increase market share by 10%, and achieve 20% ROS and 72% ROI.

Keywords: aviation,aircraft seat cushions certification,innovation for sme,co2 emission reduction,aviation safety
NonAdiabatic Molecular Dynamics of organic Intermediates in Atmospheric chemistry (NAMDIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-02
End date: 2018-05-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Earth’s atmosphere is a massive photochemical reactor, and human activities are changing its chemical composition, impacting both climate and air quality. Detailed chemical mechanisms – constructed from coupled kinetic networks of thousands of elementary reactions – are crucial in advancing our fundamental understanding of atmospheric chemistry, and developing reliable predictive models. Because the elementary mechanistic details of volatile organic compound (VOC) oxidation are often beyond the reach of experiment, in silico molecular kinetics studies (utilizing ab initio quantum chemistry and nonequilibrium statistical mechanics) are increasingly used to construct atmospheric chemistry models – particularly for describing VOC kinetics on electronic ground states. For electronic excited states, in silico studies of VOC kinetics remain an almost entirely unexplored horizon, even though light absorption and dynamics on excited states initiate most of the atmosphere’s chemistry. Neglect of excited states is increasingly problematic: for example, standard ground-state oxidation kinetics cannot explain experimental results for isoprene and toluene, two of the troposphere’s most abundant VOCs. By fusing state-of-the-art ab initio quantum chemistry, excited-state dynamics, and nonequilibrium statistical mechanics, we will carry out detailed investigations of atmospheric VOC intermediates, developing new software tools, methods, and results for direct comparison with experiments. These tools will enable theoretical chemists and atmospheric modelers to calculate in silico absorption cross-sections, quantum yields, and photolysis rate coefficients for electronic excited states of key VOCs, providing insight into how excited-state dynamics impact atmospheric chemistry on global and regional scales. This project will blaze a trail in an exciting new area of physical chemistry, tightening the link between fundamental in silico chemical dynamics and applied atmospheric chemistry.

Keywords: excited state dynamics,atmospheric chemistry,nonadiabatic effects,kinetic models,oxidation chemistry
Artificial Intelligence to transform Drug and Chemical safety testing (PATH-TOX)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Ireland,Switzerland,Belgium
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 2935000.0
EU funding (EUR): 2054499.25
Participants: 3
Project status: CLOSED

Drug discovery is a time consuming, expensive and risky process. Each drug to market must undergo safety/ toxicity testing in animals which yields thousands of tissue sections that currently must be assessed manually by a trained veterinary pathology. However, there is a looming crisis due to the lack pathologists. The PATH-TOX consortium is led by Irish SME, Deciphex Ltd, and includes key partners such as Janssen Pharmaceuticals in Belgium and Pathology Data Systems Ltd a Swiss based SME. They are creating PATHOLYTIX-TOX a computer aided diagnostic system to streamline the pathology review process. Using state-of-the-art artificial intelligence (AI) image analysis tools it will automatically identify the normal and abnormal tissues upfront, allowing the pathologist to focus mainly on the abnormal cases, hence accelerate workflow. To date, we have built a working prototype of the image analysis engine, which can identify abnormal tissue in liver. In this project we will optimise the engine further to improve performance and expand its use into other tissues. We will also develop other features such as the user interface, data management and cloud framework. Once developed, we will perform a comprehensive validation and benchmarking study to compare to manual pathology assessment. There is a large, growing, global target market for PATHOLYTIX-TOX. Pharma and CROs worldwide routinely perform thousands of animal toxicology tests each year, who are potential customers. With regards to competitors, there is no direct competition. Competitors offer individual components of the pathological workflow, not fit-for-purpose solutions for the toxicology pathology market. Overall, PATHOLYTIX would have a big impact on drug development, by reducing the time required for pathology review and associated costs. This should have a knock on effect for the global and EU markets, reducing time and cost for new drugs to get to market.

Keywords: artificial intelligence,digital pathology,toxicology pathology,pre screen,diagnosis,computer aided diagnosis,drug development
Diagnosis, prediction, communication and rehabilitation for patients with disorders of consciousness (ComAlive)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Recent work has shown that up to 42% of patients diagnosed with a disorder of consciousness (DOC) are misdiagnosed. New EEG system have revealed that some DOC patients can follow basic instructions that do not require any movement, such as imagining movement or counting vibrotactile pulses, which has even allowed them to answer YES/NO questions. This work has provided the foundations for new EEG-based solutions that could go even further – such as predicting clinical outcomes and even providing rehabilitation to facilitate cognitive and motor recovery and emergence into consciousness. The ComAlive project will develop new methods for combining EEG-based assessment and communication tools with prediction and rehab to provide new hope for these patients. The applicant is a practicing neurologist with excellent experience with DOC patients, but does not have training in business, EEG classification methods or software engineering. ComAlive is led by an R&D performing SME with a long history of real-time EEG and biomedical systems, and the other beneficiary is a hospital that is renowned for work with target patients. ComAlive includes extensive dissemination and communication activities to convey our project results to numerous audiences and supplement the ER’s training-by-research. This project will help prepare the ER for a high-impact career working across business, academic, and medical sectors while developing a new industrial system, methods and knowledge that could dramatically impact thousands of lives in the EU alone.
opportunity Zones for innovation EcosystemS governance (ZES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: CLOSED

The aim of the ZES (opportunity Zones for innovation EcosystemS governance) project is to build a logical framework for prioritizing public choices at city level towards innovation ecosystem (IEs) rationale. The proposal, moves forward the results of the MAPS-LED project (Horizon2020 – MSCA-RISE), which pointed out how urban planning in particular advanced contexts spurs IEs towards physical transformation of urban settlements in order to make the place more suitable for sharing knowledge and allowing innovation dynamics. The proposal intends to build and experiment an evaluation process framework able to support the making decision process in urban context, inasmuch as to create/empower a local IEs, closely connected with the specific assets/values of the urban context. The ZES project will focus on the Boston (US) area (Boston, Cambridge) as exploratory case furthering the investigations of the MAPSLED project, and focusing on IEs assets, governance models/structures and decision- making processes. Investigations will focus on the Boston IE addressing: innovation-oriented policies centered on IEs and their assessment frameworks; the dynamics mapping of IEs assets; the assessment of IEs assets with respect the urban context and the elaboration of an IEs evaluation framework to create/empower local IEs The results of the mapping and assessing activity will constitute the basic information to built up the IEs assessment/evaluation framework and the Smart and Open Dashboard able to support policy-makers and community-based organization in deepening the knowledge of the context and trigger its potentials for the implementation of S3 at local level through place-based and tailored urban comprehensive policies. Such process will strengthen the urban dimension of S3 multiplying the effects of RIS3, strengthening the bridge between regional and local policies and favoring the monitoring phase of the strategy adopted.

Keywords: urban dimension of s3,innovation ecosystems decision making process,urban governance,innovation oriented urban comprehensive strategy