Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Disruptive materials, technologies & approaches to unravel the role of Astrocytes in brain function and dysfunction: towards to Glial interfaces (ASTROTECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Spain,Spain,Italy,Spain,Italy,France,Czechia,United Kingdom,Portugal,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-11-01
End date: 2025-04-30
Duration (months): 54.0
Total project cost (EUR): 3980625.48
EU funding (EUR): 3980625.48
Participants: 11
Project status: SIGNED

The past four decades demonstrated that non-neuronal cells, called astrocytesare emerging as crucial players for brain function & dysfunction. A major obstacle of previous and current initiatives on Neurotechnologiesis a lack of focus on astrocytesand most of the tools used to probe and sense astrocytes are derived from those developed to study neurons. ASTROTECH will create and develop the field of Glial Engineering, to provide a consistent range of tools to record, study, and manipulate astrocytes in the healthy and diseased brain. ASTROTECH will train 15 Early Stage Researchers (ESRs) on research, training and complimentary skills aiming at: engineering biomaterials and nanostructured interfaces to provide in vivo-like in vitro models for controlled & reliable studies of astrocytes in vitro; fabrication and characterization of nanostructured devices for stimulation, recording and biosensing of astrocytes; optogenetics tools, optoelectronic device &photonic methods for precice and cell selective stimulation of astrocytes; computationalapproaches to describe and predict neuron-astrocytes interactions.The training on state-of-the-art biomaterials interfaces, electronic, photonic devices will be combined with in depth knowledge on optogenetics, neuroscience, glial physiology and biology and computational methodsto validate the developed tools in vitro, ex vivo, in silico & in pathological models of glioma, ischemia, epilepsy and depression.The ASTROTECH network combines 11 beneficiaries and 14 partners belonging to 9 European and Non-EU countries Academia, Public Research Centersand industrial labs, that combines interdisciplinary, intersectoral and soft skills knowledges where the private sector is highly representedand covers every step “from benchside to bedside” of the value chain. ASTROTECH Glial Engineeringto provide a more complete understanding of brain health and disorders.

Keywords: advanced biomaterials,flexible electronics,optogenetics,neurostimulation,computational,neuroscience,neuron glial vascular unit,neuron astrocyte interaction
NOVel, critical materials free, high Anisotropy phases for permanent MAGnets, by design. (NOVAMAG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Israel,Germany,Germany,Italy,Italy,Spain,Sweden,Greece,France,France,United States,Japan
Call: Novel materials by design for substituting critical materials (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-04-01
End date: 2019-09-30
Duration (months): 42.0
Total project cost (EUR): 7146610.0
EU funding (EUR): 5562360.0
Participants: 16
Project status: CLOSED

The demand for lower dependency on critical raw materials (CRM) such as rare earths (RE) is not only a European but a global problem that demands immediate action. The purpose of this project is to exploit advanced theoretical and computation methods together with state-of-the-art materials preparation and characterization techniques, to develop the next generation RE-free/lean permanent magnets (PM). The material design will be driven by automated large computational screening of new and novel intermetallic compounds with uniaxial structure in order to achieve high saturation magnetisation, magnetocrystalline anisotropy and Curie temperature. The simulations will be based on a primary screening detecting the mechanisms that give rise to distorted phases and stabilize them, by adding doping atoms as stabilizers. In a further computation on successfully synthetized compounds, micromagnetic calculations will be used in order to design the optimal microstructure for the given phases that will maximise the coercivity needed for a PM. Extensive experimental processing and characterisation of the selected phases will result in a first proof of principle of the feasibility of NOVAMAG PMs. A multidisciplinary team of magnet experts consisting of chemists, material scientists, physicists and engineers from academia, national labs and industry is assembled to undertake a concerted, systematic and innovative study to overcome the problems involved and develop the next generation RE-free/lean PMs. Currently the demand for these PM s is even higher with the emerging markets of hybrid/electric vehicles and wind mill power systems. The proposed project will provide the fundamental innovations and breakthroughs which will have a major impact in re-establishing the Europe as a leader in the science, technology and commercialization of this very important class of materials and help decrease our dependence on China, which will in turn improve the competitiveness of EU manufacturers.

Keywords: permanent magnets,density functional theory,molecular dynamics,microstructure,micromagnetic simulations,combinatorial synthesis,alloy synthesis
Unravelling PIM kinase signal integration in the T cell response (PIM PROTEOMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-07-01
End date: 2019-07-13
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Understanding how T cells integrate alternative signal combinations to determine immune response strength and functionality is of critical importance for rational design of immunomodulatory therapies. The PIM kinase family have been identified as important regulators of cell division, survival and protein synthesis independent of, but in parallel to the key signalling molecule mTOR. I propose to use cutting-edge quantitative proteomic technology to identify substrates and downstream protein networks regulated by PIM kinase in activated T cells. I will investigate where these downstream targets qualitatively diverge from, or quantitatively interact with, the mTOR signalling pathway (Objective 1 and 2). Using advanced cell culture and mathematical modelling I will quantify how this co-ordinated activity regulates T cell division, survival and differentiation outcomes (Objective 3). This comprehensive exploration of PIM kinase and mTOR signalling pathway integration will provide important fundamental insight into how these signals combine to regulate T cell fate and may be manipulated in the context of immunotherapy or cancer.

Keywords: t lymphocyte,pim kinase,mtor,interleukin 2,lymphocyte division,death and differentiation,signal integration,protein networks
Late Stage Fluorination and its Applications to Drug Discovery (FLUDD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-03-01
End date: 2021-02-28
Duration (months): 48.0
Total project cost (EUR): 1341024.48
EU funding (EUR): 1341024.48
Participants: 2
Project status: CLOSED

All of modern medicine is dependent on advances in chemistry and the healthcare goalposts have moved as the century has progressed. The pressing need to shorten cycle times and reduce the costs of drug discovery has led pharma and the clinicians that guide them to use scanning techniques such as positron emission tomography (PET), enabling them to increase disease understanding, study target engagement with therapeutics and improve decision making, so that only the best candidate molecules progress to the later stages of drug development. Overcoming these challenges requires multidisciplinary knowledge, and can be facilitated through stronger links between academia and Pharma. Chemical entities substituted with fluorine or fluorine-containing groups are frequently used to design drugs with improved pharmacological and pharmacokinetic profiles that provide important benefits over existing therapies, such as superior safety, efficacy, dosing, and patient compliance. Furthermore, 18F is often selected as the preferred positron-emitting isotope for the labeling of PET tracers due to its advantageous properties. The scientific objective of FLUDD is to develop novel late stage fluorination chemistry to populate the chemical and radiochemical space available for drug discovery with a focus on novel fluorine-containing fragments, molecules and biomolecules that are not directly accessible from commercial sources or the scientific literature. These novel methodologies will be applied to drugs and diagnostics discovery using both small molecules and proteins. The educational objective is to train the next generation of doctoral scientists in the practice of chemical synthesis and radiochemical methods with an in-depth appreciation of their applications in medicine. FLUDD objectives will be met with a novel Oxford-Janssen Alliance augmented with leading partners from academia, industry and the clinic.

Keywords: 18f radiochemistry,drug discovery,pet imaging
Societal openness, normative flux, and the social modification of heritability (OPENFLUX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2025-12-31
Duration (months): 78.0
Total project cost (EUR): 1987231.0
EU funding (EUR): 1987231.0
Participants: 1
Project status: SIGNED

In this project, we will use social modifications of heritability as measurement devices for assessing how social conditions shape opportunity structures, and how human potential is either constrained or enabled. Major themes in family demography and social stratification such as equality of opportunity in the age of mass education, changing family structures in the 20th century, development of life courses and careers, and intergenerational transmission processes all motivate an important role for human genetics. Up to recently, little of these efforts have directly engaged with genetic research. A common criticism of genetic methods is that they are silent on social context and environmental interactions. We turn these criticisms into tools, by assessing how genetic effects vary across contexts and environments. First, we study social change across cohorts, as influential theory suggests heritable dispositions will increase in importance when opportunity structures expand or social norms are in flux. We will test these ideas on the recent decades of family and fertility changes, and the expanding opportunity structures in education and labor markets. Second, we ask whether genetic and environmental influences on social stratification and family demographic outcomes change over the life course as the consequences of individual choice and social structures accumulate. Third, we will examine the similarity in outcomes of parents and their offspring from a genetically informed standpoint. A synergy combining state-of-the-art techniques from molecular and behavior genetics with high-quality population register data and strong theorization and measurement of socio-environmental factors from the social sciences is highly innovative cross-fertilization of research that will yield major new insights.
Rescuing the adaptive secrets of ancient quinoa (PALEOQUINOA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Quinoa is a highly nutritious grain identified by the UN as an essential crop to improve world food security. Pre-Columbian cultures started the domestication of quinoa about 7,000 years ago in the highland and coastal environments of the Andes where it is adapted to various biotic and abiotic stresses. The spread of quinoa out the centres of domestication likely required adaptation to new environments supported by favourable alleles at critical genetic and epigenetic loci. However, domestication as an intensive selection process can also lead to a reduction of the genetic diversity of domesticates, reducing their adaptability plants and threatening food security. Accessing the genetic makeup of dated archaeobotanical samples provides a powerful opportunity to examine the genomic information that has changed at various stages of domestication, enabling the identification of lost genetic diversity at key loci. Archaeological studies have reported quinoa remains dating back to 4,000 years before present, but the ancient genetic diversity remains under characterised. PALEOQUINOA will take advantage of the excellent preservation of ancient DNA molecules in archaeological specimens to track the genomic, transcriptomic and epigenomic changes in quinoa in the last 3,500 years. The unique combination of advanced ancient DNA techniques and cutting-edge computational methods will generate the first genome-scale dataset of ancient quinoa and characterise the domestication history of this crop. In addition to the genome, PALEOQUINOA will also investigate, for the first time, the transcriptome and epigenetic regulatory gene expression networks of ancient quinoa seeds, in relation to environmental changes. The new knowledge gained through this multidisciplinary approach will shed light into the evolutionary history of crop domestication and facilitate improvements in the genetic makeup of quinoa to increase its suitability as a crop at the time of ongoing biodiversity crisis.

Keywords: plant genetic resources,ancient dna,epigenetics,quinoa,food security
Rhizosphere microbiome recruitment by plants : Expansion of microRNA roles (RhizoMiR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 2
Project status: SIGNED

An innovative strategy for sustainable ‘green’ agriculture to substitute to the use of fertilizer and pesticides is urgently needed. In plants, the micro-organisms of the rhizosphere associated with the plant root, are known to affect the physiology and the development of the plant. Therefore, modulating the microbiome of the rhizosphere may be a promising strategy to achieve sustainable green agriculture. Recent research has shown that miRNAs secreted by eukaryotic host can act as an interkingdom signal to impact the viability of specific micro-organisms, including pathogens. Therefore, this EU proposal aims to explore the impact of miRNAs secreted by the plant root on the composition and gene expression of the rhizosphere microbiome. The objectives are (1) to identify specific secreted miRNAs that may influence the rhizosphere microbiome composition, (2) to analyse the biological features of the secreted miRNA-containing vesicles, (3) to understand how specific secreted miRNAs influence microbiome gene expression, (4) to determine in natura the repertoire of miRNA and associated microbiome for selected plants of agricultural interest. A combination of metagenomic and transcriptomic analysis of the soil rhizosphere from plant models (Arabidopsis thaliana and Brachypodium distachyon) under laboratory condition, as well as with selected plants of agricultural interest in natura conditions will be undertaken. The spectrum of activity of specific, or combinations of, secreted miRNAs will be also explored using A. thaliana knock-out mutants, or by perturbation of the secreted miRNAs in the WT plant using a strategy based on innovative miPEP technology. Ultimately this research can have application for miRNA-based modulation of the microbiomes of halobionts, including plants of agricultural interest. The unique complementarity of expertise between the fellow and his supervisor, completed by a well designed training program, will allow him to take up this challenge.

Keywords: rhizosphere,metagenomic,metatranscriptomic,holobiont,micrornas
Design and AI for sustainable and safe motorCYcles (DAICY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-09-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tarform launched its first two fully functioning concept prototypes on October 9th, 2018. To date Tarform has received over 700 reservations, more than 120 articles published in design and tech media and requests for partnerships from global leaders in the automotive sector, evidently proving there is a demand for this vision in the motorcycle industry. For example, the concept prototype is currently part of the new exhibition, Electric Revolution, at the Petersen Automotive Museum in Los Angeles. Adding to that, Tarform has a dynamic and entrepreneurial team with competence in a variety of sectors relevant to our mission and vision. Sectors including AI, excellence in industrial design, proficiency in software development, strong entrepreneurial drive as well as advanced digital communication capabilities. The goal of phase 1 is to investigate the technical and financial feasibility of the innovation, being an artificial intelligence platform for increased safety when riding a motorcycle, and get official commitments from a number of test partners on top of the ones we have already secured. The project will have a substantial impact in Tarform AB’s performance, with a very promising growth trajectory. By 2023, Tarform expects to reach additional revenue of €45M and create 80 new jobs in various sectors such as manufacturing, marketing, AI technology, sustainability and design. In addition to creating a more sustainable world by introducing an electric motorcycle free of CO2 emissions, the goal is also to vastly diminish injuries and death tolls relating to motorcycle use by integrating new technological features in the motorcycle utilizing the technological innovations that is currently available. Considering the initial investment budget for the Phase 1 and 2, a financial return is feasible upon the time of commercialization by year 4 (2023). Our estimated accumulated profit will then be €7.265 M.

Keywords: electrical motorcycle,safety,design,sustainable manufacturing
Infrastructure and integrated tools for personalized learning of reading skill (iRead)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Greece,Greece,Greece,Romania,Sweden,Norway,North Macedonia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Technologies for Learning and Skills (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 5547042.5
EU funding (EUR): 5114673.13
Participants: 17
Project status: CLOSED

The overarching aim of the iRead project is to develop a software infrastructure of personalised, adaptive technologies and a diverse set of applications for supporting learning and teaching of reading skills. The specific goals of the project proposed are to: 1. Develop a scalable, cloud-based software infrastructure of open, interoperable components, including real-time user modelling and domain knowledge components, to support learning of reading skills by children with different abilities and linguistic backgrounds 2. Develop domain models for English, Greek, German and Spanish learners, and to contextualise those models with respect to skills and difficulties of (i) typically developing readers, (ii) English and Greek readers with dyslexia and (ii) learners of English as a Foreign language. The domain models will utilise and generalise the domain model implemented in a previous FP7 project – iLearnRW 3. Develop applications for supporting learning (literacy games, interactive e-books, Reader app) that utilise the infrastructure to yield different types of personalised learning services and experiences 4. Develop and evaluate personalised content classification metrics that “enable reading” for use by electronic publishers and libraries 5. Enable orchestrated use of the learning applications (games, e-books, Reader app) based on learning analytics, and a personalised experience through adaptive support 6. Implement a number of large-scale evaluation pilots across European countries and providers in order to evaluate the pedagogical effectiveness of the iRead ecosystem.

Keywords: open software infrastructure,personalized learning,reading skills,user model,literacy games,interactive e books,reader app,content classification,adaptivity,learning analytics