Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Communities of Concord: Building Contentment and Belonging through Emotional Images in Early Modern Europe and Beyond (COMCON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2025-01-09
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

The project aims to uncover case studies and connections that shed light on how European identities were constructed in the early modern period. It focuses on visual and narrative paradigms/patterns—in paintings and prints—devised in Catholic and Iberian contexts between the 16th and 17th centuries and used to advance key community ideals, such as cohesion, enthusiasm and concord. In order to explore how iconographic themes and historical contexts express community bonds and values, it also deeply examines patronage, cultural networks and social groups—confraternities, religious orders and political authorities—represented in the works of art. In the process, it interrogates how the power of images served to codify emotions. It focuses on images of the triumphant and merciful church, ideal to create consensus and affiliation with the Iberian imperial and Catholic canons. It furthermore studies how these visual paradigms were transferred outside Europe, particularly in the Iberian Americas. By analysing how artistic (and social) patterns were applied and re-elaborated in new transnational contexts, the project will make a significant contribution to scholarship on how European imagery was selected and projected around the world to promote a particular idea of “emotional community”, initially as part of Rome's response to the Protestant Reformation and later as a strategy to gain new believers and subjects in New Spain. It will also explore how a normative and strategic representation of the emotions was employed—and is still used in some cases—in the politics of evangelization to shape, transmit and dictate ideal social characteristics of communities.

Keywords: connections between early modern european art histories,history of emotions,print culture,belonging,identities,community spirit
Structure-Property Relations in Aqueous Foam and Their Control on a Molecular Level (SUPERFOAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1147569.96
Participants: 2
Project status: CLOSED

Foams are of enormous importance as we find them in many technological relevant applications and food products. Foams as hierarchical materials are dominated by the arrangement and distri-bution of gas bubbles on a macroscopic scale, as well as by thickness and composition of lamella on a mesoscopic scale. Liquid-gas interfaces are, however, the building block of foam with over-whelming importance as their molecular properties easily dominate hierarchical elements on larger length scales. In order to formulate foam with specific properties, its structure must be controlled at the molecular level of a liquid-gas interface. Here, the molecular composition, molecular order and interactions such as electrostatics dominate, and thus must be addressed with molecular level probes that can provide access to both interfacial solvent and solute molecules. Specifically, mo-lecular structures of aqueous interfaces can be modified by adding different mixtures of surface active molecules such as proteins, surfactants and polyelectrolytes, and by adjusting electrolyte properties. This is achieved by varying pH, introducing ions at different ionic strengths as well as by changing viscosities. Such model systems will be characterized with nonlinear optical spectroscopy amongst other surface sensitive probes. The gained information will be used to deduce properties of structures on larger length scales such as lamella, bubbles in a bulk liquid - as a precursor of foam - and finally macroscopic foam. For each length scale, experiments will be performed to gain access to molecular buildings blocks at liquid-gas interfaces and their effects on other hierarchical elements. These experiments thus provide essential information on foam stability and bubble coalescence, they can be used to verify structure-property relationships and to advance our understanding of foam on a molecular basis.
PhotoChromic HYdrogen PERoxide biosensors for super-resolution imaging of hydrogen peroxide microenvironments (PCHYPERs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

In cells, hydrogen peroxide (H2O2) is deliberately produced and is key for a healthy cellular metabolism, and an adequate H2O2 production and delivery is required for correct cellular and tissue functions. The majority of this H2O2 production occurs in cellular microdomains, and the signalling actions in these microdomains are restricted to a very confined area. Most of these discoveries were made possible thanks to the use of genetically-encoded fluorescent biosensors that detect the changes in H2O2 concentration, including the HYPER family of biosensors. However, the details of these microdomains are missing because these biosensors rely on conventional fluorescence microscopy methods, which are limited in spatial resolution. This project aims to overcome the resolution limitation in H2O2 imaging by developing photochromic variants of the HYPER biosensors, known as PCHYPERs, that can be utilized in super-resolution microscopy. This will enable to discern the gradients of metabolic H2O2 at a high resolution, helping identify the role of H2O2 as a cellular messenger in signalling pathways and the functional implications of its disturbance.

Keywords: hydrogen peroxide,fluorescent proteins,biosensors,photochromism
Insect social parasites: behavioural genomics models for understanding the basis of phenotypic evolution (SocParPhenoEvol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

Understanding how diversity of life arises at the level of the genes is one of the biggest challenges in modern biology. Genomic methodologies now allow us to dissect the molecular basis of this phenotypic diversity and plasticity. However, we lack an integrated study of key phenotypic traits and their dynamic changes in an ecologically relevant setting, with the associated dynamic nature of the underpinning genes. I propose to use an inter-disciplinary approach, by uniting classical ethology with new molecular tools of genomics, to understand how genes give rise to phenotypic traits and their dynamic plasticity using an insect social parasite system as model. Insect social parasites show striking phenotypic diversity compared to their hosts and have been identified as unique models for understanding the molecular basis of phenotypic diversity and plasticity. Yet, they have remained largely unexploited so far, due to the difficulty of conducting genomic studies on non-model organisms. This project will combine for the first time the transcriptomic (i.e. multiple species comparisons of brain genome-wide RNA-seq analyses followed by candidate gene approach RT-PCR) and behavioural phenotyping in order to reveal the molecular basis of phenotypic diversity in a Polistes paper wasp social parasite system, which comprises the social parasite, the host and a related non host species. This will be a landmark project in the exploding field of Behavioural Genomics as it will ensure high replication in an ecologically relevant setting in wild populations and it will exploit a deep ethological knowledge of the model system to ensure precise integration of behaviour with new methods for dissecting molecular processes. This project offers a unique opportunity to capitalize on molecular and behavioural expertise of the Supervisor and ER, generating the most comprehensive empirical and theoretical body of work to date, thus placing the ER as a leader in this new and exciting field.

Keywords: social parasitism,social insects,phenotypic plasticity,polistes,gene expression
Novel treatment of inflammatory diseases (NOTID)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LipUm has discovered a novel treatment of rheumatoid arthritis (RA) and potentially other inflammatory diseases by a unique therapeutic antibody directed towards the Bile Salt-Stimulated Lipase, which has been identified as a key target to block and thereby inhibit the inflammatory process and prevent joint destruction. The global prevalence of RA is 0.3-1%, and it is twice as common among woman than men, and the risk to develop the condition increases by age. Frequently, other serious diseases are co-occurring with RA and according to the World Health Organisation 50% of patients in developed countries are unable to hold a full-time job within ten years after disease onset. The societal economic burden due to the disease is thus enormous, while health economic calculations estimate the cost for pharmaceuticals to less than 20% of the total cost. Still, the drug market value growth between 2014 and 2019 is expected to increase by 55% to 30 billion USD. The introduction and use of biologicals such as the TNF-alfa inhibitors constituted a major achievement in the treatment, but with time it has also been concluded that 1/3 of patients are not responding and another 1/3 experience only a transient improvement. As these biologicals suppress the immune system such drugs should not be combined with other immunosuppressants, as it may create adverse health effects. Key opinion leaders have therefore pointed out the need for drugs that have a complementary therapeutic mechanism. This is the gap that LipUm intends to fill and a tentative strategy is to apply for a orphan drug designation for juvenile idiopathic arthritis that affect children, frequently with extreme disability and poor quality of life. As an orphan drug our unique biological more rapidly could contribute to improved treatment of the 85,000 children diagnosed with the disease in Europe.

Keywords: rheumatoid arthritis,juvenile idiopathic arthritis,orphan drug,antibody,autoimmune,inflammation,tnf inhibitor
ERA-Chair in Science and Innovation Policy and Studies (SInnoPSis)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Cyprus
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2019-12-01
End date: 2025-05-31
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The ERA Chair in Science and Innovation Policy & Studies (SInnoPSis) aims to attract a high calibre academic in order to bring together excellent academics from the linked scientific departments and consolidate all related research activities at the University of Cyprus (UCY). This vision will be realised by attracting and maintaining an international calibre professor accompanied by a group of exceptional scientists in the field of Science and Innovation Policy and Studies (SIPS), coupled with the establishment of a multidisciplinary research unit which will allow optimal exploitation of the existing research capacity and infrastructures of UCY and facilitate the gradual upgrade of the research activities in the field. The principal thematic focus will be on the SIPS field, including all connected fields with emphasis on Economics & Management and secondarily Social and Political Sciences, Philosophy and Information Technology. The Chair will be the Research Director of the foreseen SIPS research unit having full autonomy in carrying out a research programme formulated by him/her a few months after the recruitment. This will enable the ERA-Chair team alongside scientists from linked departments of UCY whose expertise ranges in these fields to produce cutting-edge multidisciplinary research output and innovative educational and training programmes. The Chair will also create significant impact in Cyprus, by contributing with the expertise and research results of her/his group in advocating the Chief Scientist, the National Council of Research and Innovation and the Research Promotion Foundation in significant issues related to SIPS and the implementation of research and innovation policies in Cyprus. UCY will make all necessary arrangements and institutional changes needed to attract top scientists for the ERA Chair position and facilitate their scientific autonomy and optimal impact of their research.

Keywords: science and innovation policy and studies,economics and econometrics of science and innovation,randi policy,innovation management,scientometrics,science diplomacy,social studies in science
Autonomous Wireless Current Sensor for Aircraft Power Lines (AMPWISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Switzerland,Switzerland,France,United Kingdom
Call: Development of autonomous, wireless, smart and low cost current sensor for monitoring of electrical lines (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-02-01
End date: 2021-07-31
Duration (months): 42.0
Total project cost (EUR): 973747.5
EU funding (EUR): 879788.63
Participants: 4
Project status: CLOSED

AMPWISE will develop an energy autonomous wireless smart and low-cost current sensor for remotely monitoring of electric lines in the context of the coming generation of aircraft. This includes the definition of a sensor architecture co-designed to achieve an optimal balance between the harvested energy and the consumption of sensor and electronics, while meeting the desirable sensing, latency and sampling specifications. The current sensor design will build on an existing product adapted to meet the form-factor, size and sensing requirements. The simulation of the wireless communication system will guide and validate the design and parameters. The wireless communication will operate in the desirable 4.2-4.4 GHz band in compliance with ITU regulations. The protocol will support reliable, secure, low-power and time-bounded communications, and will tolerate interference and co-existing networks, including in metallic environments. The power supply will use inductive power line harvesting and a resonant power management approach to improve power density, dynamically tunable to the line frequency, and employing magnetic field guiding to meet form factor and installation requirements. The developed concept will reach TRL 5. A laboratory testing facility will be used for evaluating the integrated wireless sensor network. The consortium includes two industry, SENIS (CH), a sensor manufacturer, and SERMA (FR), an OEM for aeronautical equipment. It also includes CSEM (CH), a RTD with long experience in space and aeronautical projects and Imperial College London (U.K.), a university with significant track record in Energy Harvesting, including prototypes for aircraft. The project will build on existing expertise on aircraft power line harvesting and consortium-level experience, know-how and method in co-designing wireless autonomous aircraft sensors. CSEM, Imperial and Serma have previously worked together on developing such aircraft sensors, within Cleansky.

Keywords: low power autonomous wireless current sensor energy harvesting aircraft
Dielectric measurement of two-dimentionally confined biomolecules at the nanoscale (Dielec2DBiomolecules)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-10
End date: 2021-09-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Macromolecular organization and interactions have long been recognized to be strongly influenced by electrostatic and electrodynamics interactions which in turn depend on the molecular polarizability. In particular, molecular polarization plays a fundamental role in the molecular structure of biomolecules like DNA and proteins. Yet, this physical property of biomolecules has remained almost unexplored so far because measurements on the molecular scale are a technical challenge. Previous experimental work mostly relied on standard approaches as such broadband dielectric spectroscopy which are limited to the micrometer scale and, therefore, cannot resolve the polarization properties of single molecules. Hence, new experimental approaches are needed to measure the polarizability of molecules at molecular level. In this project, we will tackle this important issue and develop a novel experimental platform that will allow to access for the first time the polarizability of biomolecules under two-dimensional (2D) confinement. This will be achieved by coupling two novel technologies of nanoscience: scanning dielectric microscopy, a recently developed scanning probe technique, and the 2D-materials technology. We will engineer novel 2D liquid cells by assembling 2D crystals, and we will measure the dielectric properties of the biomolecules confined inside using a scanning probe. This is an ambitious experimental research with a strong interdisciplinary and groundbreaking nature, based on the powerful combination of new microscopic approaches with novel 2D materials. The developed platform will access previously unknown physical properties of biomolecules that are crucial to understand their behaviour. It will provide much-needed feedback for first-principles and mean-field theories and allow a better understanding of biomolecular structure and functions.

Keywords: graphene,2d materials,scanning probe microscopy,atomic force microscopy,dielectric polarization,nanofluids,electrostatic interactions,van der waals forces
Bioengineer novel eco-friendly natural colour fibre through genetic manipulation of the phenylpropanoid and betalain pathways in cotton (Colour cotton)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-28
End date: 2024-06-20
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Cotton fibre is one of our most important textile resources. Most commercial cotton fibres are various shades of white but can be yellowish because of poor environmental conditions during growth or storage. A bleaching step is employed to address this issue during cotton fabric processing. After cotton fibre is spun into yarn, a dyeing process is applied to colour natural fibre to satisfy costumer’s demand. Additional industrial processes are needed to remove unfavourable natural colours and then add desirable colours to the yarn. Each step costs substantial amounts of energy but more importantly causes serious water and air pollution. More than 100 litres of water are required to dye one kilogram of cotton. The industrial effluents are rich in hazardous material. To address these issues, the proposed research will aim to bioengineer high value eco-friendly naturally coloured cotton fibre. Two overall strategies will be pursued. Firstly, by down-regulating key genes in the phenylpropanoid pathway, we aim to reduce fibre yellowish to increase fibre whiteness for the premium market. Second, by reorientating the metabolic flux from the phenylpropanoid pathway into a heterologously expressed betalain biosynthesis pathway, we aim to engineer novel natural colour cotton. The prospective products will significantly alleviate the environmental issues of the textile industry where 20% of global water pollution is produced and provide a biotechnological solution for a more environmentally friendly textile industry.

Keywords: cotton,natural colour fibre,genetic transformation,genome editing,phenylpropanoid pathway,betalains