Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification of subtype-specific biomarkers in small cell lung cancer (BIOSMALL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Hungary,Germany,Sweden,Netherlands
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 952200.0
EU funding (EUR): 897000.0
Participants: 7
Project status: SIGNED

Although small cell lung cancer (SCLC) is a particularly aggressive disease, targeted therapies have remained largely unsuccessful and there were no major therapeutic advances in the last three decades. In the clinics, SCLC is still treated as a molecularly homogeneous malignancy. However, recent analyses led to the classification of neuroendocrine and molecular subtypes, defined by differential expression of four key transcription regulators: ASCL1, NEUROD1, POU2F3 and YAP1. Our study proposal aims to identify unique subtype-specific diagnostic and therapeutic biomarkers for SCLC patients with state-of-the-art multiomic approaches, and moreover to deepen our understanding of the biological and clinical significance of SCLC molecular subtypes. We intend to investigate the diagnostic and therapeutic significance of each subtype in a large panel of human SCLC cell lines in correlation with their proteomic and metabolomic profiles, in vivo metastatic capacity and sensitivity to potential targeted agents. Additionally, the specific features of the molecular subtypes will be also assessed by performing genetic mutation analyses and using in-depth machine-learning algorithms. All potential circulating biomarkers delineated by proteomics and metabolomics will be first validated by a series of in vivo experiments in different murine models. In addition, in order to improve patient selection and follow-up in a non-invasive manner, the specific PET-CT radiomic features of enrolled patients will be also analysed within the framework of the current study. Altogether, by identifying a wide range of novel biomarkers and potential therapeutic targets via multiomic approaches, the current study will possibly result in a new subtype-specific biomarker panel which will contribute to the development of individualized diagnostic and/or therapeutic strategies in this hard-to-treat disease.

Keywords: small cell lung cancer,molecular subtypes,diagnostic and predictive biomarkers,therapeutic targets,proteomics,radiomics
Metal-organic frameworks as concerted proton-electron transfer mediators for electrocatalysis (eCat-MOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

As the consequences of the anthropogenic contamination become more evident and irreversible, there is an increasingly urgent need to switch towards more sustainable paradigms in the chemical industry. In this context, the utilization of renewable energy sources via electrocatalysis has emerged as a highly active field of research during the past decades, although further efforts are required to provide economically viable technologies with practical applications. eCat-MOF project aims at developing efficient electrocatalysts for chemical reactions based on reductive protonation. These processes are ubiquitous to a large number of industrially relevant transformations such as reduction of olefins, carbon dioxide or dinitrogen. An electrocatalytic approach will offer a sustainable alternative to harness renewably sourced electricity to power such transformations, avoiding current harmful processes that pose important obstacles towards a circular economy. The strategy of eCat-MOF project is based on accessing concerted proton-electron transfer (CPET) reactions due to their energetic benefits allowing operation at milder potentials and thus outcompeting the otherwise dominant hydrogen evolution reaction. To this end, eCat-MOF will target the design of novel CPET mediators based on an interdisciplinary approach: incorporation of molecular redox and acid/base mediators in the structure of metal-organic frameworks (MOFs) and the immobilization of the resulting materials on carbon-based electrodes. This strategy merges the fields of molecular inorganic/organometallic chemistry, reticular materials and heterogeneous electrocatalysis to overcome challenges associated to undesired bimolecular reactivity, low current density, limited Faradaic efficiency, difficult product separation and catalyst recovery. The expected implications of eCat-MOF will have a broad impact in the progress towards the integration of renewable energy schemes into the chemical industry.

Keywords: metal organic frameworks mofs conductive mofs,electrocatalysis,concerted proton electron transfer,small molecule activation,renewable fuels,organic electrosynthesis
PREcision Studies with Optically pumped Beams of Exotic Nuclei (PRESOBEN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2184375.0
EU funding (EUR): 2184375.0
Participants: 1
Project status: SIGNED

Neutrons are fascinating particles and are important for nuclear structure, tests of the standard model of particle physics, or properties of neutron stars. Unfortunately, they are electrically neutral, so learning about their distribution in nuclei, especially far from stability, is difficult. However, they possess a magnetic moment, which contributes to –and sometimes dominates– the distribution of nuclear magnetization. This project aims to address the challenging question of the distribution of magnetisation and neutrons in unstable nuclei. I will use a novel, high-accuracy experimental approach, combining radiation-detected Nuclear Magnetic Resonance with rf-laser double spectroscopy on optically-pumped short-lived nuclei. The project builds on recent achievements in my team, allowing to determine magnetic moments of unstable nuclei up to ppm accuracy. I will combine this approach with accurate measurements of the hyperfine structure using the laser-rf double-resonance. The signals will be detected efficiently using decay anisotropy, thanks to spin polarisation via optical pumping. This will lead to an accurate determination of a ‘hyperfine anomaly’, a small effect on atomic hyperfine structure due to the distribution of nuclear magnetisation. A close collaboration with atomic and nuclear theorists will allow to determine the magnetisation and neutron distribution in many nuclei: light neutron-halo 11Be, proposed halos in neutron-rich Ne, Na, Mg, K, and Ca nuclei, and heavy Rn, Fr, and Ra isotopes, interesting for studies of atomic parity violation (APV) and electric dipole moments. The project will take place at the ISOLDE facility at CERN. I will also work closely with quantum-chemistry, atomic- and nuclear-physics theorists, who will use our data to improve their approaches. This will open new perspectives for nuclear structure studies, determination of neutron-star properties, or APV studies. It will also allow test of atomic and nuclear calculations.

Keywords: unstable nuclei,nuclear magnetic resonance,optical pumping,laser spectroscopy,hyperfine structure,magnetization distribution,neutron distribution,spin polarization,beta decay,decay anisotropy,beta detected nmr,hyperfine anomaly,rf spectroscopy
Greening Beyond Borders: Understanding the Role of Supply Chains in Environmental Sustainability (GREENCHAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

GREENCHAIN will establish a robust and innovative foundation for advancing our understanding of supply chain sustainability, by 1) developing an interdisciplinary theoretical framework that integrates perspectives from economics, management, finance, operations management, and industrial engineering and 2) establishing empirical frameworks that leverage cutting-edge econometric approaches, novel data sources, and real-world contexts from Europe and Japan. The project will investigate the reasons, mechanisms, and conditions under which firms pressure their suppliers to reduce environmental impacts, identify key characteristics that make firms more proactive in these actions, and assess the broader implications for customers, suppliers, the environment, and the economy. GREENCHAIN's interdisciplinary approach will provide policymakers and businesses with critical insights into the drivers and dynamics of sustainable supply chain practices while equipping them with tools to evaluate the financial and environmental returns of these initiatives. Hosted by the globally renowned IESE Business School and supported by its Sustainability initiatives, I will enhance my abilities in project management, theoretical development, advanced quantitative data analysis, and the communication of research findings – skills essential to establish myself as a leading expert in corporate sustainability management and contribute to both academic discourse and European policy on sustainable supply chains.

Keywords: supply chain sustainability,corporate sustainability management,environmental policies,natural disasters,climate change,firm to firm networks,green innovation
High-Energy Accelerators for Radiation Testing and Shielding (HEARTS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Switzerland,Germany,France,Italy,Slovenia
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3599965.0
EU funding (EUR): 3599965.0
Participants: 7
Project status: SIGNED

The main purpose of the HEARTS proposal is to provide high-energy (>100 MeV/n) heavy ion accelerator access to space users, in order to mimic the effects of Galactic Cosmic Rays (GCR) at ground level, and thus fulfilling the needs of microelectronics qualification and shielding & radiobiology experiments. These ions will successfully mimic the effects of heavy ions present in the GCR spectrum, and will also ensures penetration levels large enough to enable electronics testing in air, without the need of electronics device preparation (e.g. de-lidding, thinning) and at board and box level. High penetration ion irradiation is essential in order to facilitate the exploitation of high-end microelectronics technology in space, for e.g. onboard artificial intelligence or Big Data processing applications. To this end, the HEARTS proposal features CERN and GSI as accelerator infrastructure partners, who also gather a vast experience and knowledge in radiation effects on electronics, and shielding & radiobiology, respectively. Moreover, HEARTS features also the University of Padova as academic partner, and Thales Alenia Space and Airbus Defence and Space as industrial participants, all of which have ample experience in the radiation effects domain, and a strong interest in VHE ion testing. The academic and industrial partners will define the requirements, both technical and procedural, for VHE ion user facilities. Such requirements will serve as input to CERN and GSI and will be implemented as upgrade which, once completed, will be scrutinized and validated by the industrial and academic partners, through “real case” experimental campaigns that will in turn serve as input for the development of VHE ion testing recommendations and guidelines. Therefore, in final instance, HEARTS ambitions to create a high quality and sustainable VHE ion irradiation capacity in Europe, accessible to and tailored for space users and applications.

Keywords: radiation,electronics,shielding,radiobiology,space,heavy ions,galactic cosmic rays,high energy accelerators
Predictive maintenance by Ravitex® SmartSensor on electrodes, welding guns and cutters to make BIW processes based on RSW (resistance spot welding) processes controlled in real time, stable and replic (SmartSensor)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: SIGNED

Predictive maintenance by Ravitex® SmartSensor on electrodes, welding guns and cutters to make BIW processes based on RSW (resistance spot welding) processes controlled in real time, stable and replicable. In vehicle construction, the quality of the welded connections is crucial for the stability and longevity of the body. Even the smallest deviations in the electrode surface can lead to inadequate weld spots. The BiW (Body in White) automotive assembly process relies heavily on RSW (Resistance Spot Welding) and suffers significant production (and revenue) losses due to frequent production line stoppages. These stoppages are mainly caused by weld quality issues, which in turn arise from poorly maintained consumable “tips” on welding guns. In current welding processes, real-time electrode control is not possible. Ravitex® SmartSensor is a fully automated adaptive control system that will transform Tip Dresser & Changers from simple machine tools to Industry 4.0 solutions used for predictive maintenance of electrodes and welding guns achieving high, consistent and repeatable weld spot quality that will transform RSW-based BiW processes: from process repeatability uncertainty to “real-time controlled, constant progress repeatability”. Another key feature of the patented Ravitex® SmartSensor will be that it will make spot welding of aluminum sheet metal economically feasible.

Keywords: stable and replicable tip dressing quality,tip surface quality control,check of,height,of oxidation craterization of tip
CONNECTED.SPACE – Unlocking Sustainable 5G-IoT Connectivity From Space (CONNECTED)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In a digitally-driven era, connectivity is pivotal to economic and societal growth. Yet, in a surprising reality, 80% of the planet lacks proper connectivity, revealing the shortcomings of traditional networks in ensuring accessibility, affordability, and scalability. Satellite communication is often the only feasible means in off-grid areas to exchange data, even minimal messages. This gap significantly affects access to key services across diverse applications such as smart agriculture, asset tracking, and ocean surveillance, deepening the digital and economic chasm. CONNECTED, a Portuguese startup, aims to become the world's first space-based NB-IoT connectivity network global operator, utilising a hosted payload strategy on third-party Earth Observation satellites. By leveraging its space infrastructure, which is 20 times cheaper than current alternatives, CONNECTED offers a unique proposition: affordable, global, standard and sustainable IoT connectivity based on non-proprietary protocols, especially 5G IoT Non-Terrestrial Networks (NTN). CONNECTED’s novel approach – an IoT gateway integrating in-situ data via IoT with EO data - will unlock new possibilities for IoT-based business models and enhance the quality of life, all without jeopardising the sustainability of the space ecosystem. Founded in Portugal in January 2023 and comprising 13 FTEs, CONNECTED thrives on a vision of offering affordable, standard, and sustainable global connectivity. EICs support will be instrumental for CONNECTED’s success, allowing in-orbit demonstration and validation, as well as the launch of the pilot network and complementary 5G NTN services.

Keywords: connectivity,narrowband internet of things nb iot,payload,low earth orbit,earth observation,5g,nt icms
Next-Generation Gravitational Waveforms (NextGW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

The NextGW project aims to revolutionise gravitational wave (GW) astronomy by developing next-generation waveform models for extreme-mass-ratio inspirals (EMRIs), which will be critical for the success of the future space-based GW observatory LISA. EMRIs provide unique insights into the strong-field regime of gravity around supermassive black holes, enabling precise tests of general relativity and a deeper understanding of the fundamental nature of black holes. Accurate models are essential for detecting and interpreting these signals, and this project will push the frontiers of waveform modelling by incorporating astrophysically realistic features, including the spin of the primary black hole, eccentric orbits, and precession. By enhancing the predictive power of gravitational self-force (GSF) theory, NextGW will pave the way for transformative discoveries that could reshape our understanding of gravity, space-time, and the universe. As a Marie Skłodowska-Curie Fellow, I will receive world-class training at the University of Southampton, working closely with leaders in the field of GW science. This fellowship will provide me with advanced expertise in GSF theory, waveform modelling, and data analysis, as well as training in interdisciplinary collaboration, project management, and public engagement. By collaborating with the LISA Consortium and participating in international research efforts, I will be well-prepared to lead future research initiatives in gravitational wave astronomy. The outcomes of NextGW will advance the scientific objectives of upcoming GW observatories like LISA and the Einstein Telescope and contribute to Europe’s leadership in a field poised to revolutionise fundamental physics.

Keywords: gravitational waves,black holes,black hole binaries,general relativity,gravity,gravitational wave modelling,black hole perturbation theory,self force
StarTric - A novel transcatheter medical device to treat Tricuspid Regurgitation (StarTric)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Tricuspid Regurgitation (TR) poses a significant health challenge, affecting millions worldwide. Current treatment options, primarily open-heart surgery, come with inherent risks and are often unsuitable for frail patients. StarTric has pioneered a transcatheter device tailored to the intricate task of addressing TR. Drawing inspiration from the highly successful open-heart "clover" technique, this innovative device offers a minimally invasive alternative for TR repair. The StarTric device will reshape the tricuspid valve into a clover-like configuration, effectively restoring proper valve function. By replicating the efficacy of the clover procedure through transcatheter means, StarTric's solution holds immense promise in transforming the lives of countless patients globally. To bring this breakthrough solution to patients in need, StarTric requires funding support to accelerate development, clinical trials, regulatory approval and commercial efforts.

Keywords: cardiac healthcare,tricuspid regurgitation,transcatheter therapy,cardiology,heart valve repair,cardiovascular,medical devices,innovative treatments,healthcare,cardiac health,medical innovati
The adoption of hydrogen metallurgy in the climate-neutral production of steel (HELIOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands,Finland,Austria,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2829449.83
EU funding (EUR): 2716898.4
Participants: 10
Project status: SIGNED

The HELIOS Doctoral Network will train 10 motivated and talented Doctoral Candidates (DCs) in breakthrough technologies for the hydrogen-based production of green steel, including both carbon steel and stainless steel. These DCs will be equipped with the necessary science capital and diverse transferable skills to pursue their careers in Europe and become the experts that our society needs to achieve the climate-neutral production of steel by 2050. The intersectoral training programme is dedicated to the technical and economic challenges and innovative developments associated with the transition to hydrogen-based green-steel production. The combination of state-of-the-art doctoral research projects, intersectoral secondments and supervision by leading companies (Tata Steel, SSAB Europe Oy, Aperam Stainless Europe, Heraeus Electro-Nite International and LUXMET), universities (KU Leuven, TU Delft, University of OULU, MU Leoben) and competence centres (K1-MET) will be the foundations of HELIOS’s success. HELIOS targets in 3 interconnected scientific work packages to (1) engineer processes and develop models to leverage the hydrogen-based steel production route to the same state-of-the-art level as the BF-BOF route for carbon steel; (2) develop first-of-a-kind hydrogen-plasma smelting reduction processes for stainless steel production; (3) design and evaluate innovative hydrogen and/or hydrogen plasma-based processes to recover and separate metals from stainless steel residues; and (4) develop measuring and analysis tools and models supporting the application of hydrogen-based processes for steel production.

Keywords: carbon neutral steelmaking