Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Josephson maser and heat transport in dissipative open quantum systems (XmonMASER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

My proposal is devoted to study the heat transport in dissipative open quantum systems. My main scientific and technological goals are: (i) to study the effect of anharmonicity in the heat transport in a dissipative open quantum system; and (ii) to realize a Josephson maser, to demonstrate coherent emission of microwave photons driven by a superconducting transmon qubit. To study heat transport in the quantum limit I propose a device with a qubit coupled to two resonators, each terminated by mesoscopic normal-metal reservoirs acting as source and drain thermal baths. When a thermal bias is applied across the system, the heat is transmitted between the two mesoscopic reservoirs via the qubit, and dissipated in the drain reservoir. With a sufficiently electron temperature in the heated reservoir, the population inversion prerequisite will be satisfied, and the proposed system will work as a maser, allowing for efficient on-chip generation of coherent microwave photons at low temperatures. The proposed system provides a platform to study the heat transport in dissipative open quantum systems, and both spontaneous and stimulated microwave emission. Therefore, I will contribute a pioneering technology to the field of quantum technology, and environment engineering for quantum technologies, in addition to developing a promising tool for quantum thermodynamics. The fundamental knowledge of quantum physics targeted in my proposal will be immediately applicable in several applied fields; the microelectronics industry, quantum computers, and communication sectors, and it will have a great impact on society both in Europe and globally. This fellowship will advance my career plans, enabling me to become an expert in circuit quantum thermodynamics, and receive leadership and management-oriented training. In return, I will transfer my theoretical and experimental knowledge in quantum photonics and optics obtained during my PhD to PICO group.

Keywords: quantum thermodynamics,dissipative open quantum system,superconducting quantum bit,quantum heat engine,quantum refrigerator,microwave photons generation,nano fabrication,circuit qtd
Reversible Covalently Binding PROTACs Technology for Protein Degradation in Cancer Therapy (RECOBIN-PROTACs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Today's challenge for modern medicine is the development of tools that can selectively target cancer cells over healthy cells. Acute myeloid leukemia (AML) is an aggressive blood cancer of the myeloid cells causing bone marrow failure. Drug development research uses small molecules to inhibit the activity of proteins promoting cell proliferation. The higher concentrations of drug required for efficient inhibition often lead to off-target effects. Recent years, proteolysis targeting chimeras (PROTACs) technique receives much attention for therapeutic intervention by degradation of disease-causing proteins. However, the requirements of PROTACs such as high affinity and specificity ligands, poor stability, cell permeability, lack of cell specificity limit the broader utility of this technique. Here, we propose a novel rational design and synthesis of reversible covalently binding PROTACs (RECOBIN-PROTACs) based on the proximity labeling. A RECOBIN-PROTAC molecule consists of target protein ligand, E3 ligase ligand and a chemoselective functional group connected through flexible linkers. The chemoselective functional group forms reversible covalent modification with proximal Lys residue of BET protein or E3 ligase. This proximity labeling enhances the binding affinity of the ligands to the targets, stabilizing protein-protein interactions in ternary complex formation. The library of RT53 based RECOBIN-PROTACs will be tested on AML cell lines to find most efficient degraders. Also, the chemoselective group masked by self-immolative linker connects with enzyme-labile group and cysteine reactive handle. The most efficient RT53 based RECOBIN-PROTACs will be conjugated site-selectively to cysteine antibody to generate stable RECOBIN-PROTAC-Antibody Conjugates. These conjugates selectively release the active RECOBIN-PROTAC inside the target cells upon protease cleavage. The features of RECOBIN-PROTACs technology will bring new modalities in therapies and drug discovery.

Keywords: acute myeloid leukaemia,targeted protein degradation,protacs,recobin protacs,proximity labeling,reversible covalently binding,drug discovery,cancer therapy,cysteine bioconjugation
optiSLATER: Automated Classification System for the categorization of slate slabs. (optiSLATER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Slate manufacturing heavily relies on subjective and costly manual work for the quality control and categorization of its products during which the price of the final product is defined. Due to the subjectivity of this manual process and the labor shortage dur to hard and harmful working conditions (carcinogenic components), this industry is urgently requiring accurate, unbiased and automated classification systems, able to reduce production costs, increase productivity, competitiveness and traceability but also improving the working conditions of the employees. In ITCN (Spain, 2016) we are working for bringing technology to the traditional slate sector. We have developed optiSLATER: the first automated classification system for slate slabs. It provides for the first time an unbiased and consistent categorization of slate slabs x6 times faster than the manual process while guaranteeing the traceability of the final products. Based on computer vision & artificial intelligence algorithms, optiSLATER retrieves and analyze in a few seconds all the relevant parameters to classify the slabs solving the subjectivity of this crucial process w. Besides, it allows the full traceability of the products as it generates a report with all the classification parameters per slate batch as well as a code bar. optiSLATER can increase x5 the productivity of the slate manufacturing companies (46,000 slabs vs. 9,200 manual classification in a shift) avoiding the contact of the employees to the harmful slate dust. optiSLATER can be assembled with our own packaging and palletizingunits to offer a complete automated solution to for the final slate processing steps. Based on direct sales, we will offer optiSLATER to the European slate manufacturing companies (B2B) expecting to gain more than 100 customers after the first 3 years of commercialization. It will represent €9,1M in cumulative profits (ROI of 4,2, breaking even in less than 1,5 years) while hiring at least 4 new employees.

Keywords: slate,processing,classification,manual process,harmful,silicosis,traceability,slate slabs
GEM in-wheel motor (GEM in-wheel)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Germany,Germany,Slovenia,Slovenia,France
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2015-12-01
End date: 2017-12-31
Duration (months): 25.0
Total project cost (EUR): 2753850.0
EU funding (EUR): 1991945.0
Participants: 6
Project status: CLOSED

In the frame of the project we will finalise the development and the market placement of our new electric drive inside the wheel that will represent a technological break-through and will address mobility challenges in EU and global urban transportation. The GEM in-wheel product represents unique solution on the targeted market with integrated motor controller and electric motor inside the wheel. Using patent pending modular technology, the product significantly improves the state-of-the-art characteristics of in-wheel products on the global market by increasing efficiency (above 92%), torque (higher up to 25%) and lowering weight (up to 25% to competitive products). In addition the modular technology also allows a very easy adaption to various customer needs allowing to develop a cost-efficient complete product range. Main competitve advantages of our solution are: smart and simple design, low voltage, modular technology, regenerative braking, easy scalability, high reliability, excellent motor performance and excellent price/performance ratio. To achieve project goals a trans-disciplinary consortium with competent partners on their field is established. The project leader Gem motors as developer of the motor technology, joined forces with experienced partners that complement their roles: Domel as long-term and well established company in the field of electric motor production, Fraunhofer IAO as the first class research institute in the e-mobility field of production and business management, Luznar as small competent producer specialized in-wheel power electronics and City motion-Eccity as an emerging key producer of electric scooters in EU. Other third parties for motor parts production, research, structural analysis and five key customers are completing the network thus forming a complete and competent consortium to successfully accomplish the project’s objectives. Project topics are directly in-line with the Work Programme FTI.

Keywords: in wheel,e drive,hub motor,electric vechicles
A new integrated process to valorise hazardous leaded glass from CRTs and transform it into high performance geopolymer blocks - VirtuCrete (VirtuCrete)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The world is sitting on a ‘CRT mountain’; For TVs and monitors, Cathode Ray Tubes have been the main screen technology, up until the revolutionary change to LCD and plasma screens that has recently taken place. Consequently, the current CRT population (1.9 billion screens; 500 million of them in Europe) is becoming obsolete and will require processing (not landfill) according to WEEE regulations, since the high proportion of lead in the glass means that landfills have an unacceptable risk of lead leaching into groundwater. The very low manufacturing rates for new CRT worldwide now mean that recycling the glass back into CRTs is no longer an option, and the only alternatives to avoid landfill have been to use the glass as a smelting flux (85% of it remains as a toxic slag), or using foundry temperatures (1000°C) melt extraction for the lead, which is extremely energy and CO2 costly, and at best produces an 80% co-stream of low value glass. Our idea is to process leaded CRT glass using a novel hydrochemistry method to precipitate out the lead, which can be sold. The residual output stream from our VirtuCrete process contains an alumino-silicate mix that can be used as an alternative to Ordinary Portland Cement (OPC), to produce a high-silica concrete geopolymer block. This new material has exceptional resistance to salt, acids and water, making it suitable harsh conditions and flood defences, and high temperature resistance (over 1200°C) making it applicable to fire risk applications such as road tunnels or waste storage segregation. The novel chemistry also allows use of recycled aggregate, potentially reducing the cost of our geoblocks by 50% compared to OPC blocks. The new technology could enable EU waste recyclers and concrete block producers to co-operate to solve the CRT problem and to increase competitiveness through new products, to gain market share and capitalise on new business opportunities.

Keywords: crt lead glass geopolymer concrete blocks cement
Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE (JUMPING JIVE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Spain,South Africa,Italy,Sweden,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2016-1, 2016)
Start date: 2016-12-01
End date: 2021-07-31
Duration (months): 56.0
Total project cost (EUR): 2983682.5
EU funding (EUR): 2983682.5
Participants: 13
Project status: CLOSED

“Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE” (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scientists and operators of radio-astronomical facilities, by widely advocating its science capabilities and its role as research infrastructure provider within the international radio astronomy community. These activities will focus on outreach and on reinforcing science cases for the next decade. New partnerships will be pursued, and in addition JIVE will expand its potential user base by offering geodetic and enhanced astrometric processing. Finally, the possibility of the International LOFAR Telescope using the same ERIC governance structure in the future will be investigated. With respect to global VLBI, the aim is to place JIV-ERIC in a leading role in the definition of scientific and technical standards in the SKA era. JIVE will take charge of a number of operational interfaces that will be essential for truly global VLBI, and establish close connections with the African VLBI Network and the SKA as the main strategic partners for the next decade.
Fibre-Optic Multi-parametric BIochemical Sensing Technology (FOMBIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-12
End date: 2017-10-11
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project aims at developing advanced optical fibre sensing technologies for multi-parametric bio/chemical measurement, urgently demanded from industry and scientific research for quality control and process study. The Fellow, Dr Jiang will be trained on a series of skills related to novel photonic devices and advanced sensing techniques at main host Aston Institute of Photonic Technologies (AIPT) and several other EU hosts. Capitalising upon his original expertise in the study of optical fibre sensing, bio/chemical measurement and liquid diffusion process, the fellowship will make him a unique asset to the EU for tackling multi-parametric bio/chemical sensing by developing new optical fibre sensing technologies capable of measuring several parameters simultaneously. Dr Jiang has proven track record in bio/chemical sensing with interdisciplinary background and his achievement has been outstanding though very young as demonstrated in his CV. The skills and technologies he will grasp will allow him to diversify his capability significantly; including fibre grating design and fabrication (at AIPT), UV and femtosecond laser micro-fabrication, fibre laser, optical fibre interferometry, nano-film coating techniques and modelling techniques for photonic devices, and highly sensitive sensing technologies. In addition, the fellowship will allow him to transfer the knowledge gained through the research to the benefit of his hosts and regional industrial liaisons together with his existing knowledge on bio/chemical detection. Starting from a particular optical fibre device, tilted fibre grating, through modelling, fabrication and optimisation on special fibres the project will explore the rich spectral characteristics of the device to decode a variety of factors for the multi-parametric sensing. Fostered by the fellowship, a leading expert in photonic sensing technologies is expected and will contribute greatly to EU industries and academic communities.

Keywords: tilted fibre grating,chemical measurement,fibre grating fabrication,nanofilm coating,fibre cavity ring down
SSPH+ Global PhD Programme in Public Health Sciences (GlobalP3HS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Switzerland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 9156000.0
EU funding (EUR): 4578000.0
Participants: 1
Project status: SIGNED

The Swiss School of Public Health (SSPH+) - a foundation of eight Swiss universities - seeks to launch a Global PhD Programme in Public Health Sciences (GlobalP3HS) to competitively recruit 50 talented students from around the world to pursue PhD studies in Switzerland. More than 150 SSPH+ faculty members are engaged in interdisciplinary public health sciences and are highly qualified to supervise and train the next generation of public health leaders in both the academic and non-academic sector. Self-driven, critical public health scientists are needed to improve public health on a global scale by providing scientific evidence to shape policies, health systems, life-styles, economies, laws and regulations. Recruitment will be initiated with a global call. Applicants must be eligible for PhD studies in Switzerland and provide a letter of support from a committed supervisor of the SSPH+ community. An International Review Board will score applications on a scale of 0 - 10, based on four dimensions. The Steering Board will select the best candidates (scores ≥8). To guarantee the highest standards for PhD studies, students must register in one of the structured PhD programmes led by SSPH+ partners — programmes that adhere to the quality standards of PhD education as defined in the EU Charter for Researchers. Students choose programmes from a wide range of interdisciplinary offers, including health economics, public health, epidemiology, social health sciences, nursing or law. Students must pass at least 18 ECTS, including formal training in transferable skills and research ethics. Furthermore, secondments are offered to allow students to explore non-academic career paths as well. SSPH+’s long-standing experience with highly successful inter-university PhD programmes make SSPH+ well-placed to implement a doctoral programme that builds capacity in public health sciences on a global scale and prepares students for academic as well as non-academic career paths.

Keywords: health economics,social health science,health law,prevention,health promotion,scholarship,secondment,epidemiology,public health,doctorate,international collaboration
Quantifying the impact of Tropospheric Chlorine Oxidation Chemistry (Trop-ClOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1651508.0
EU funding (EUR): 1651508.0
Participants: 1
Project status: SIGNED

This project addresses a fundamental and yet highly unconstrained question in atmospheric chemistry: What is the impact of atomic chlorine on the composition of the troposphere? Gas phase oxidants control the concentrations of important climate and air pollutants such as methane, ozone and particles. Accurate representation of oxidation chemistry in computational models is paramount to our ability predict and understand past, present and future changes to the Earth system. Over recent decades there have been continual suggestions that the chlorine atom may be a significant tropospheric oxidant, but a lack of observations capable of constraining its chemistry mean that its role remains highly uncertain. Without these underpinning observations, our understanding of atmospheric oxidation and thus our ability to develop effective and timely policies to address air quality and climate change is compromised. This project will provide a step-change in our understanding of atmospheric chlorine chemistry. Capitalising on recent technology advances, two innovative instruments capable of definitively constraining chlorine atom sources and sinks will be developed. These instruments will be deployed at three chemically contrasting locations (Cape Verde, coastal Netherlands and central Germany), generating the first comprehensive dataset on tropospheric chlorine atom production and loss. These data will be used to challenge the state-of-the-science representation of chlorine chemistry in atmospheric chemistry models. Ultimately this work will advance our understanding of the fundamental chemistry occurring in the atmosphere and help to direct developments in the next generation of air quality and climate models.