Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chaetogenesis in Annelids illumina'ted (CHAETA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Chaetae, the chitinous bristles, of segmented worms are without a doubt one of their most characteristic features. A single cell, called chaetoblast, forms these complex extracellular structures, through an intricate interplay of the cytoskeleton and controlled polymerization of chitin. I have been investigating this fascinating system and published a series of papers describing the process of chaetal formation in various annelids using serial TEM and histology. With this proposed project I will combine my previous training and take the next logical step in the study of chaetogenesis; by investigating the molecular underpinnings of chaetal formation, focusing on chitin synthases. Chitin is one of the most dominant biopolymers in nature and a key building block of diverse extracellular structures. The bone eating worm Osedax japonicus will be the main focus of this study. Its fast and simple chaetal development, together with the drastic anatomical difference between males and females, renders it a perfect model to link the differential expression of chitin synthases to any relevant point of chaetogenesis that can be ultrastructurally profiled. Genetically well-examined annelid Capitella teleta will serve to test the functional genetics of chitin synthases using CRISPR/CAS9. This integrative approach combining advanced microscopical techniques with cutting-edge transcriptomics will result in a giant leap towards revealing the genetic network regulating chaetogenesis. I will be laying the groundwork to fully understand how morphologically complex, chitinous hard structures can be formed by a single cell. Elucidating the molecular and cellular mechanisms behind this process, that is comparable to a biological 3D printer, is highly relevant for not only annelid researchers but also to a broader scientific community studying biomechanics, biomineralization, cell-biology and even bionics.

Keywords: organogenesis,chaetogenesis,morphogenesis,annelida,ultrastructure,chitin
Tuning Tubulin Dynamics and Interactions to Face Neurotoxicity: a Multidisciplinary Approach for Training and Research (TubInTrain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Spain,Italy,Switzerland,France,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 3409972.92
EU funding (EUR): 3409972.92
Participants: 8
Project status: SIGNED

TubInTrain is a Consortium of 7 beneficiaries and 14 partners from 6 European countries joining their forces to train 13 Early Stage Researchers (ESRs) for n European Joint Doctorate. TubInTrain mission is to: - develop an Elite European Doctorate School to train ESRs in the context of neurodegeneration as well as in essential scientific, entrepreneurial and management skills; - create a multidisciplinary and multi-sectorial network for long-term cooperation in the research training of internationally oriented scientists for the global workplace; - train a new generation of cutting-edge researchers/professionals for employment by highly attractive European Institutions. The ESRs will work on an integrated innovative research project focused on the microtubules breakdown associated to neurodegenerative diseases and neurotoxicity. Despite the constant improvement in medical treatments, a significant leap in therapies for such diseases has been lacking for a long time. This calls for an ever-renewing effort in the investigation of their basic pathological mechanisms. This objective will be achieved through fertile collaborations between the partners, which have diverse expertise, ranging from computational chemistry to neurobiology. The Consortium will manage the recruitment/supervision/assessment processes. Each ESR will be co-supervised by two Beneficiaries, delivering the double degree, and a Partner. Two secondments are planned to improve the ESR research and training programs with management skills. ESRs will benefit of lectures/Training Schools/Workshops integrating the local graduate programs. This process coaches ESRs to: rise to challenges, be flexible/adaptable, achieve valuable attributes for today’s knowledge-based environment, be ready for creative and leadership roles in industry/academy/public sectors. All the know-how built up among the Consortium will spread out to external groups through exposures, public engagement, network and outreach activities

Keywords: tubulin,microtubules,molecular modeling,fiber diffraction,organic synthesis,alpha synuclein,aggregation
Development of Integrated MEasurement Systems (DIMES)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Switzerland,United Kingdom,United Kingdom
Call: Advanced Integrated Testing Methods development (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2019-01-01
End date: 2021-09-30
Duration (months): 33.0
Total project cost (EUR): 1320261.25
EU funding (EUR): 1199901.25
Participants: 4
Project status: CLOSED

The aim of the project is to develop advanced integrated testing methods that have the capability to detect a crack or delamination in a metallic or composite structure and have the potential to be deployed as part of an on-board structural health monitoring system for passenger aircraft. The proposal incorporates a new philosophy for monitoring damage in which the disturbance to the strain field in the structure caused by the damage is used to identify significant damage and to track its propagation. Recently, this approach has been demonstrated to be at least as effective in composite structures as traditional non-destructive evaluation techniques and, in CS2 project INSTRUCTIVE using infrared technology, it has been shown to be capable of identifying smaller cracks in metallic structures than any other available technique. In this project, it is proposed to amalgamate these innovations with more established techniques, such as strain gauges and acoustic emission, and to demonstrate an integrated testing method. The objectives are designed to mature technologies from TRL 4 to 6 that are likely to have a disruptive impact on the structural health monitoring of next generation large passenger aircraft The objectives are: i) to develop a robust and innovative concept for integrating a diverse set of sensors and data acquisition systems for detecting and monitoring damage in an aircraft assembly; ii) to produce an integrated system of sensors and data acquisition systems deployed on a test bench representing an aircraft assembly, and; iii) to conduct prototype demonstration and evaluation tests of the integrated system and test bench using independent systems. The primary outcome will be the demonstration, on a test bench consisting of an aircraft assembly, of an integrated measurement system for ‘on-line’ detecting and monitoring damage based on a diverse range of sensor systems.

Keywords: remote sensing shearography thermoelasticity digital image correlation thermal ndt fibre bragg fbg strain gauges structural health monitoring
The Emergence, Life, and Demise of Autocratic Regimes (ELDAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

ELDAR will investigate three aspects of autocratic politics: 1) the emergence of autocratic regimes; 2) policy-making (“life”) in autocracies in the areas of education, infrastructure, pensions and media regulation; 3) autocratic regime breakdown. ELDAR offers a comprehensive perspective, highlighting the interconnections between these three aspects – for example, the particular policies chosen may mitigate or exacerbate specific risks to the regime – and studying them jointly in one framework. ELDAR will address the preferences and capacities of vital actors in autocratic politics – the leader, regime support groups, and mobilized opposition groups. Special attention will be directed towards identifying and linking the different actors entering support and opposition coalitions to constituent social groups (e.g., industrial workers and landowners). Team members will also study the specific, and diverse, institutions that underpin autocracies, such as characteristics of regime parties or legislative elections. In extension, ELDAR will explicitly model – theoretically and empirically – how support- and opposition groups and institutions interact in affecting regime change and policy making in autocracies. Examples of more specific questions include: Are autocracies less willing to use the education system for ideological indoctrination if the regime tightly controls the media environment? Are autocracies less likely to break down if they provide generous special pensions to military officers? To investigate such questions empirically, ELDAR will collect data, with global coverage and long time-series, on the numbers, social identity and other features of groups that support and oppose regimes. These efforts yield unprecedented opportunities for large-n studies of autocratic emergence and demise. Three other datasets, on education systems, buildings, and pensions, will also enable pioneering empirical studies on core policy areas in autocracies.

Keywords: autocracy,authoritarian regime,regime change,regime survival
Post-transcriptional and post-translational mechanisms underlying B cell selection by T cells in germinal centers (PostTransGC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Enduring protection from pathogens and robust responses to vaccination depend on the generation of high-affinity antibodies through the germinal center (GC) reaction. In GCs, T helper cells promote the extensive proliferation of high-affinity B cell clones and their differentiation into plasma cells through cellular interactions that modulate gene expression. Here, we aim to unravel multiple post-gene expression mechanisms, including mRNA and protein stability regulation, that jointly control the outcome of T-B interactions in GCs. Since it is technically challenging to examine gene transcription and cellular contacts simultaneously, a method that links these two processes and measures transcription in-situ is required. To understand how T cell help controls gene expression dynamics and persistence of mRNA transcripts in GC B cells, we will use LN-smFISH, a new method we recently developed that combines imaging of individual cells and single mRNA transcripts within lymph nodes. Through in-vivo manipulation of B cells and co-visualization of single cells and mRNAs, we will define the dynamics of gene expression during T-B contacts and plasma cell generation in GCs (Aim1). Using our specialized in-vivo models, we will examine how modulation of mRNA stability and translation by transcript methylation controls B cell clonal expansion and define which genes are regulated by this machinery (Aim2). Finally, we will examine how the degradation of known and novel key proteins control gene networks and B cell fate in GCs (Aim3). Together, we envision the establishment of a unifying model for how sequential layers of regulation orchestrate the translation of T-B interactions to fate decisions. The findings may lead to improved vaccine strategies and expose new checkpoints for manipulation in autoimmune diseases and GC-derived lymphoma. On a broader scale, we expect to define new concepts about the role of mRNA and protein stability machineries under physiological conditions.

Keywords: germinal centers,b cells,antibodies,lymphocytes,immune cell interactions
Thin-disk lasers for the 2-micron spectral range based on Ho-doped monoclinic double-tungstate epitaxial structures (TDL2Ho)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The research activities planned will be devoted to development, test and characterization of novel thin-disk structures based on epitaxially grown monoclinic double tungstate crystals for use in high average /peak power all-solid-state laser systems operating in the important 2-µm spectral range. Laser gain will rely on the Holmium (Ho) trivalent ion which is potentially very suitable for high energy due to its advantageous spectroscopic features. The latter allow one to excite it directly into the upper laser level, producing less heat and enabling power scaling with diode pumping. Moreover, wavelengths slightly above 2 µm, emitted from such tunable Ho-lasers, are attractive for various applications.

Keywords: thin disk lasers,high power lasers,double tungstates,epitaxial structures
Cardiovascular Molecular Imaging for Personalized Tailored Treatment (Neuroheart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Objectives of the proposal: Heart Failure (HF) is estimated to cost the EU economy €196 billion a year. Currently, patients are treated with the highest pharmaceutical doses of antiRAS agents, which cause severe side effects and reduce the patients’ quality of life. Moreover, treatment responses are highly variable. This study aims to enable imaging-guided treatment optimization by using a radiolabelled novel angiotensin 1 receptor (AT1) blocker analogue in a small animal model of myocardial infarction (MI). Positron emission tomography (PET) as a cutting-edge method of evaluating HF pathophysiology at a molecular level will be employed to optimize treatment. How the objectives will be achieved: MI will be obtained by ligation of the coronary artery in Wistar rats. Subsequently, PET imaging with a dedicated small animal system (mciroPET) will be performed. A multiple set of cardioneuronal PET tracers provided by the partner institution at Johns Hopkins University will be used to measure the extent of global and regional neurohumoral abnormalities in rat hearts following different degrees of ischemic insult. The relationship between neurohumoral system alterations and subsequent left ventricular remodelling will be determined by microPET and Magnetic Resonance Imaging to assess deterioration of ventricular geometric parameters. Using the novel AT1-ligand, imaging-guided dose-derived therapeutic concepts for Wistar rats will be established in vivo with the aim to transfer this technique to the clinic in a long term perspective. Relevance to the Work Programme: I envisage that in the future a single cardiac PET scan prior to treatment initiation will be sufficient to estimate the appropriate drug dose in any given HF patient. This new concept of individualized drug dose determination has the potential to lead to personalized treatment for one of the most frequent fatal and expensive diseases and thereby contributes to the reduction of the economic burden of the EU.

Keywords: heart failure,heart,sympathetic nerve,imaging,personalized treatment,radionuclide,positron emission tomography,myocardial infarction,ischemia
Future European Fuel Cell Technology: Fit for Automatic Manufacturing and Assembly (Fit-4-AMandA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Belgium,Netherlands,Denmark
Call: Manufacturing technologies for PEMFC stack components and stacks (H2020-JTI-FCH-2016-1, 2016)
Start date: 2017-03-01
End date: 2020-11-30
Duration (months): 45.0
Total project cost (EUR): 2999185.0
EU funding (EUR): 2999185.0
Participants: 7
Project status: CLOSED

The main target of our work is to industrialise the stack production, to deliver affordable fuel cell systems in larger quantities to saturate the emerging market/demand. Heart of our call is to build a worldwide new and unique machine which allows serially* produce the centrepiece of fuel cell system: the stack.This will revolutionize the way how stacks are produced in future. The members of the consortium are: a developer and producer of fuel cell systems (Proton Motor Fuel Cell GmbH), a supplier of MEAs and BiPolar Plates (BPP) (IRD), a supplier of industrial machinery for assembly, handling and testing equipment (AUMANN), two renowned research institutions (Technische Universitat Chemnitz / ALF, Fraunhofer IWU) and a EU project management expert (Uniresearch B.V.) and last but not least, UPS an international transport OEM with its own vehicle production of Light Commercial Vehicles. The result of our project work can be used for several purposes: Branding, Prototyping and Business development. The stacks can be used outside of automotive industry, because they can be adapted to other applications (such as uninterruptible power sources) by the design of a fuel cell system.

Keywords: mass production,cleantech,automation,pemfc stack,bipolar plate
Contradictory Logics: A Radical Challenge to Logical Orthodoxy (ConLog)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2059026.0
EU funding (EUR): 2059026.0
Participants: 1
Project status: SIGNED

“The acceptance of contradictions must lead ... to the end of criticism, and thus to the collapse of science.” – Karl Popper, Conjectures and Refutations. In the 20th century, many systems of non-classical logic have been developed, including inconsistency-tolerant logics, which are typically all subsystems of classical logic. There are, however, logical systems that are radically different from classical logic insofar as they are non-trivial but contradictory. These logics are in glaring conflict with logical orthodoxy since Aristotle, who called the Principle of Non-Contradiction the firmest of all principles. Non-trivial contradictory logics, sometimes called “dialetheic logics,” not only permit inconsistencies in theories, but contain provable contradictions. Can that be reasonable? The Contradictory Logics project (ConLog) takes on the challenge of this rigorous break with the Aristotelian tradition by systematically investigating and developing non-ad hoc contradictory logics. In particular, ConLog studies non-trivial dialetheic systems of connexive logic that already validate certain contra-classical principles, such as the thesis saying that no proposition implies its own negation, and so-called “logics of logical bilattices.” ConLog develops a clear comprehension of the contradictoriness of non-trivial dialetheic logics and studies the consequences of this understanding within the philosophy of logic. Thereby, the project will yield a paradigm-shift in our conception of what a respectable logical system and an acceptable scientific theory is. It will show that, contrary to the above quote from Popper, the inconsistency of a logical system does not prevent rational belief and does not lead to the end of criticism and a collapse of science. It will achieve this ambitious goal by applying techniques from philosophical logic, such as the use of Chellas-Segerberg models, as well as methods from structural proof theory and experimental philosophy.

Keywords: philosophical logic,connexive logic,negation,msc2010 03b53 paraconsistent logics,msc2010 03b60 other nonclassical logic,msc2010 03f03 proof theory,general including proof theoretic semantics