Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing CRISPR activation/CRISPR interference toolset for fine-tuning production of metabolites in plants (METABOTUNE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Plants produce a great variety of specialised metabolites. In plants they are often involved in interactions with their environment, but many of them have applications in pharmaceutical, cosmetic, and food industries, making them targets for metabolic engineering efforts aiming to increase their production. Plant metabolic engineering is usually based on metabolic pathway reconstitution in microbes, but recently direct activation of biosynthetic genes has been done in plants using CRISPR tools. METABOTUNE aims to develop a CRISPR toolset for simultaneous activation and inactivation of metabolic genes to fine-tune biosynthesis and maximise yields of specialised metabolites. First, I will develop a CRISPR interference (CRISPRi) tool for inactivating genes that channel metabolites into undesired metabolic pathways. Second, I will identify genes involved in the biosynthesis of a coumarin metabolite with medicinal properties, esculetin. Finally, CRISPRi will be applied together with the already available CRISPR activation (CRISPRa) tool in development of plant cell cultures specifically producing esculetin and the minimal amount of other coumarins. To achieve these objectives, I will combine my expertise in molecular biology, genetics, specialised metabolites, and biochemistry with the expertise in metabolic engineering and coumarins available at the host institute. Allowing precise channelling of metabolites into pathways of interest, as proposed here, will open new venues for highly specific plant metabolic engineering efforts and allow a shift from production in microbes to increasing production in plant species that already have genes required for biosynthesis of high-value specialised metabolites.

Keywords: specialised metabolites,crispr,coumarins,metabolic engineering,plant culture
Disruption of Mucin Glycosylation and Mucus Barrier Function in Response to a Western-Style Diet (GlycoDiet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

In the healthy intestines, mucus acts as a barrier that separates the host epithelium from the microbiota and intestinal contents, as well as a habitat for commensal microbes. The major component of intestinal mucus, MUC2, is heavily O-glycosylated. Mucin O-glycans are critical for mucus barrier function and host-microbe interactions. Alterations to mucin glycosylation have been associated with diseases such as inflammatory bowel disease and cancer, and represent a novel target for therapeutic intervention. However, studies of the specific glycan structures altered during disease, as well as the consequences of these alterations on mucus barrier function and the microbiota, have been limited by a lack of tools to detect individual glycan epitopes. Mucus barrier dysfunction and microbiota dysbiosis, specifically a shift towards expansion of mucin-degrading bacteria, have been observed in response to a high fat/sugar, low fiber western-style diet (WSD). My preliminary data indicates that a WSD can also alter specific mucin glycosylation patterns. The identification of specific glycan alterations associated with a WSD creates the opportunity to study the role of individual glycan structures in mucus barrier dysfunction and microbiota composition. This study aims to 1) develop novel probes to detect specific glycan epitopes and 2) use these probes to investigate the relationships linking mucus barrier dysfunction, glycan alterations, and dysbiosis in response to a WSD. I will combine my previous experience characterizing glycan alterations in in vivo models of intestinal disease with host lab training in mucus physiology and bacterial enzyme characterization. Findings will advance our understanding of how glycosylation patterns are altered during disease, and how these alterations contribute to disease pathogenesis. This grant will allow me to enhance my skills as a researcher and give me the tools and experience necessary to establish my independent research group.

Keywords: mucus,o glycans,binding proteins,microbiota,dysbiosis,diet,glycosylation
Plants in the ancient Near Eastern texts. A transdisciplinary analysis of the human-plant relations in Mesopotamia during the Neo-Assyrian and Neo-Babylonian periods (PlANET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: SIGNED

PlANET project aims to reconsider the role of ten plant species in Mesopotamia during the Neo-Assyrian and Neo-Babylonian periods (10th–6th cent. BCE) in religious, ideological, scholarly, gender, and economic spheres. It aims also to prove cases of human overexploitation of plant resources causing ecological traps, whose long-term effects are still experienced today. The project is the first full-scale study permitting us to dramatically increase our knowledge of Mesopotamian human-plant relations, by producing an innovative transdisciplinary non-anthropocentric paradigm, involving the methods of historical-philological and anthropological research, the archaeobotanical literature and the tools of Digital Humanities. It will set up an open-access database offering a systematic integration of textual data and archaeobotanical information to establish links between plant emic names, identifications, and activities described in textual sources. Such data variety will be analyzed in the light of Ecological Anthropology and Environmental Humanities. This holistic approach will make the outcomes relevant to a broad academic community since the addressed questions and methodologies can be used in other research fields, regions, and periods. The Dep. SARAS (Sapienza) and NELC (Penn) are the perfect places to acquire new multidisciplinary skills (study of cuneiform economic texts, Digital Humanities, and archaeobotany) and to open significant future academic career paths. SARAS has an anthropological section, while NELC collaborates with the Penn Museum, crucial to the successful implementation of the project. The results will be disseminated and communicated through various channels and audiences (online database, scientific works, statement for Iraqi Ministry of Environment, conference, popular science articles, social media, exhibition, and children’s book). The communication strategy contributes to a greater awareness of the important role of plants in human life.

Keywords: assyriology ancient near east ancient mesopotamia assyria babylonia cuneiform studies plant symbolism ancient human plant interaction environmental humanities
OPTIMISING COLORECTAL CANCER PREVENTION TROUGH PERSONALISED TREATMENT WITH ARTIFICIAL INTELLIGENCE (OperA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Denmark,Sweden,Poland,Spain,Greece,United States,United Kingdom,Japan,Italy,Germany
Call: Clinical validation of artificial intelligence (AI) solutions for treatment and care (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 4674997.5
EU funding (EUR): 4674996.0
Participants: 19
Project status: SIGNED

Integration of artificial intelligence (AI) technologies into clinical medicine has been hampered by challenges related to uncertain long-term clinical benefits, cost-effectiveness, and ethics/legal concerns. Application of AI in colonoscopy, a forefront research topic, has been also bothered by these issues. AI is, however, expected to reduce colorectal cancer incidence and mortality through personalised treatment. Our proposed project would change this discouraging situation and thus drastically improves colorectal cancer care. We achieve the following goals: 1. Establish the value of AI-assisted colonoscopy in colorectal cancer prevention by conducting a pan-European, population-based, randomised trial with 222,000 participants. 2. Develop a colonoscopy AI risk-prediction tool for personalized treatment of colorectal polyps and cancer. 3. Develop cost-effectiveness models of AI-assisted colonoscopy in colorectal cancer screening. 4. Investigate ethical and legal barriers in AI development and implementation. 5. Generate the first trustworthy and rapidly updating (?living?) clinical guidelines for AI in screening colonoscopy. 6. Develop a patient-oriented AI tool by including end-users in the process of AI development and communication. Our research consortium maximises the feasibility of the project, with world-class experts in gastroenterology, machine learning, cancer screening, biostatistics, disease modelling, regulatory science, and ethics and law in medicine from nine European countries, the US and Japan. We also partner with a European medium-size AI enterprise for implementing the output of the project. The project has large potential impact on patients, society, and economy in Europe, and the World. Up to 6,000 fewer deaths due to colorectal cancer and saving of 720 million euro can be expected per year once the technology is widely accepted in Europe.

Keywords: epidemiology public health clinical trial cancer prevention cancer screening
Modern Mediterranean Archaeological Regimes in a Global Context (MMARe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

Contrary to conventional narratives on the history of archaeology and official museum narratives, arguing that Mediterranean states and societies neglected antiquities, archaeological legislation was adopted for the first time in the European North and in the Mediterranean. Modern Mediterranean Archaeological Regimes in a Global Context (MMARe) investigates the Mediterranean legal archaeological regimes from 1789 to 1945, individually and comparatively. It similarly traces their influence at the international level, through the League of Nations (LN). MMARe contributes with novel approaches and substantive arguments to the debate on decolonizing the museum, and suggests concrete tools for provenance research and ways forward in the discussion on the restitution of antiquities. It is hosted by Ca’ Foscari University (UNIVE) in Italy and Columbia University (CU) in the US, and includes a secondment at Brown University (BU), also in the US. It is supervised by Dr Konstantina Zanou (CU) and Dr Yannis Hamilakis (BU), who are experts on the debates on Mediterranean heritage, as well as Dr Matteo Legrenzi (UNIVE), who specializes in international organizations and the modern Middle East. It also benefits from the specialized courses, library resources, skills training and communications opportunities, as well as the vibrant academic communities, of these three institutions.

Keywords: mediterranean history,archaeological legislation,league of nations
Arabic Linguistic Discourse in the Making (ALiDiM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1496241.0
EU funding (EUR): 1496241.0
Participants: 1
Project status: SIGNED

The ALiDiM project proposes a metalinguistic analysis of the process of standardization of Classical Arabic as it has been described by early Arabic scholars. By analyzing the earliest Arabic grammatical texts under one metalinguistic roof, this project aims to find new ways to account for and analyze texts that challenge conventional conceptions of the origins of the Arabic linguistic tradition. Embedding linguistic production into a wider cultural framework, the project introduces methodological innovations by devising an interdisciplinary approach. The investigation will focus on the metalinguistic process of language description itself, rather than on the linguistic features described. With the objective to develop an unconventional new reading of the origin and formation of the Arabic linguistic tradition, the ALiDiM project will explore a variegated corpus of Arabic grammatical and lexicographical sources and picture the narratives presented by early Arabic scholars. The focus will be on identifying, tracing, and elaborating the earliest stages of formation of the Arabic linguistic tradition, through a reconstruction of the internal factors that gave rise to the emergence of the linguistic studies as well as the points of convergence between the Arabic and neighboring traditions. The ALiDiM project will trace origins and receptions of the linguistic themes, identifying the factors that altogether contributed to the process of language standardization of Classical Arabic. The methodology applied by the early Arabic scholars will also be studied with a twofold approach that accounts for both the local Arab-Islamic framework and possible external influences. Research data will be made available via the project’s website as a digital corpus of TEI-encoded, semantically-annotated original sources.

Keywords: arabic philosophy of language metalinguistics circulation of knowledge digital humanities
Management and completion of dynamic Knowledge Graph (MOKA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Luxembourg,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

In MOKA, we will design and implement methods for managing the evolution of large and dynamic knowledge graphs (KG). Currently, KG are getting much attention from both industry and academia because they have properties that support the design and development of more intelligent and intelligible systems by connecting and structuring knowledge, ensuring semantic interoperability between information systems and providing richer content for automatic reasoning. However, one of the most widely agreed-upon problems experienced by data scientists and knowledge engineers is the maintenance of such KG over time. Since KG model the knowledge of a given domain, they have to be frequently updated to reflect the evolution of that domain which demand significant effort from experts and once updated changes are lost which leads to a general impoverishment of knowledge over time. To do so, our methods and tools will allow to (i) identify and characterize changes that occurs in KG when the domain evolves which will significantly reduce the efforts of domain experts in the KG maintenance tasks and (ii) define a mechanism to represent the evolution of a domain within a so-called Historical Knowledge Graph (HKG) that will allow users having a clear and deep understanding of the evolution of the domain knowledge over time. The proposed methods and tools will be evaluated on the KG of the Open Research Knowledge Graph initiative and the data of the space domain. We will have a significant impact on scientific, technological, economic and societal aspects. This will be made possible thanks to the proposed dissemination, exploitation and communication plans aimed at a large audience that will facilitate the development of the career of the researcher.

Keywords: knowledge graph evolution
Conceptualising Intercultural Mediation in the Greek-Roman Antiquity. A multidisciplinary approach (CIMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

Intercultural mediation is a social practice that creates bonds between individuals or groups from different cultural background through the agency of a third party. The agent, or mediator, can be either an individual or a group of people (e.g. an ambassador, a translator, a salesman; immigrants, pilgrims, tourists, and so on) whose activity, often unintentionally, reinforces international relationships and fosters social cohesion especially for what concerns culturally distant and/or hostile groups. The practice exists from ancient times, prompt by various political and economic factors, and the understanding how and why it occurred, and why it succeeded or failed in the past can greatly impact the studies related to intercultural exchange, by amplifying our understanding of social mechanisms that may promote cultural tolerance and manage conflicts. However, current studies related to multicultural coexistence overlook this issue, and the research is further impeded by the lack of a universal theory on mediation or a valid methodology of its study. The CIMA project aims to fill this gap by studying a real-life phenomenon in a historical perspective, in order to enable the use of past sociocultural experiences to address current social issues. Namely, CIMA will examine a series of case studies that emphasize the activity of the ancient Greeks as diplomatic mediators, trading agents and/or transmitters of concepts and ideas between foreign communities (states/tribes), and will develop an adaptable model of analysis of this phenomenon, applicable in various disciplines and fields. Inthis manner, the project will transcend the conventional boundaries between disciplines and open new, interdisciplinary directions for future research. The outputs of the project will be disseminated both in written form in journals, conference proceedings and social media, and as oral presentations, targeting researchers, students and the general public.

Keywords: intercultural mediation international relations ancient multiculturalism and society greeks and barbarians ancient trade politics,conflict and diplomacy
Adaptive Scheduling and Deployments of Data Intensive Workloads on Energy Efficient Edge to Cloud Continuum (ENACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Spain,Germany,Portugal,Ireland,Bulgaria,Romania,Slovenia,Poland
Call: Cognitive Computing Continuum: Intelligence and automation for more efficient data processing (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6407047.68
EU funding (EUR): 5055074.0
Participants: 18
Project status: SIGNED

ENACT develops cutting-edge techniques and technology solutions to realise a Cognitive Computing Continuum (CCC) that can address the needs for optimal (edge and Cloud) resource management and dynamic scaling, elasticity, and portability of hyper-distributed data-intensive applications. At infrastructure level, the project brings visibility to distributed edge and Cloud resources by developing Dynamic Graph Models capable of capturing and visualising the real-time and historic status information, connectivity types, dependencies, energy consumption etc. from diverse edge and Cloud resources. The graph models are used by AI (Graph Neural Networks - GNN) models and Deep Reinforcement Learning (DRL) agents to suggest the optimal deployment configurations for hyper distributed applications considering their specific needs. The AI (GNN and DRL) models are packaged as an intelligent decision-making engine that can replace the scheduling component of open-source solutions such as KubeEdge. This will enable real-time and predictive management of distributed infrastructure and applications. To take full advantage of the potential (compute, storage, energy efficiency etc) opportunities in the CCC, ENACT will develop an innovative Application Programming Model (APM). The APM will support the development of distributed platform agnostic applications, capable of self-determining their optimal deployment and optimal execution configurations while taking advantage of diverse resources in the CCC. An SDK to develop APM-based distributed applications will be developed. Moreover, services for automatic (zero-touch provisioning-based) resource configuration and (telemetry) data collections are developed to help design and update dynamic graph models. ENACT CCC solutions will be validated in 3 use-cases with challenging resource and application requirements. International collaboration is planned as Japan Productivity Center has committed to support with knowledge sharing.

Keywords: cognitive computing continuum,ai,dynamic graph models,graph neural networks,deep reinforcement learning,hyper distributed applications,application programming model,zero touch,sdk