Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering cell heterogeneity in tumors using arrays of nanowires to controllably poke single cells in longitudinal studies (NanoPokers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2023-08-31
Duration (months): 84.0
Total project cost (EUR): 2621251.0
EU funding (EUR): 2621251.0
Participants: 1
Project status: SIGNED

Cancer is responsible for 20% of all deaths in Europe. Current cancer research is based on cell ensemble measurements or on snapshot studies of individual cells. However, cancer is a systemic disease, involving many cells that interact and evolve over time in a complex manner, which cell ensemble studies and snapshot studies cannot grasp. It is therefore crucial to investigate cancer at the single cell level and in longitudinal studies (over time). Despite the recent developments in micro- and nanotechnologies, combined with live cell imaging, today, there is no method available that meets the crucial need for global monitoring of individual cell responses to stimuli/perturbation in real-time. This project addresses this crucial need by combining super resolution live-cell imaging and the development of sensors, as well as injection devices based on vertical nanowire arrays. The devices will penetrate multiple single cells in a fully controlled manner, with minimal invasiveness. The objectives of the project are: 1) To develop nanowire based-tools in order to gain controlled and reliable access to the cell interior with minimal invasiveness. 2) Developing mRNA sensing and biomolecule injection capabilities based on nanowires. 3) Performing longitudinal single cell studies in tumours, including monitoring gene expression in real time, under controlled cell perturbation. By enabling global, long term monitoring of individual tumour cells submitted to controlled stimuli, the project will open up new horizons in Biology and in Medical Research. It will enable ground-breaking discoveries in understanding the complexity of molecular events underlying the disease. This cross-disciplinary project will lead to paradigm-shifting research, which will enable the development of optimal treatment strategies. This will be applicable, not only for cancer, but also for a broad range of diseases, such as diabetes and neurodegenerative diseases.

Keywords: nanowires,nanotechnology,semiconductor,super resolution microscopy,epitaxy,nanosensors,nanoinjections,microfluidics,tumor,cell heterogeneity
Elucidation of autophagy using novel chemical probes (ChemBioAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1414550.89
Participants: 2
Project status: CLOSED

The interest on autophagy, an evolutionarily conserved process in eukaryotes, has enormously increased in the last years, since autophagy is involved in many diseases such as cancer and neurodegenerative disorders. Autophagosome formation is the key process in autophagy. Despite extensive work, the model of autophagosome formation is not yet well established. Some important questions on autophagosome biogenesis remain to be elusive, such as where the bona fide marker protein of autophagosome, LC3, is lipidated, how lipidated LC3 functions in autophagosome formation, and how the proteins for LC3 lipidation and delipidation are involved in autophagosome formation. Although genetic approaches have been useful to identify genes involved in autophagy, they are chronic and thereby the dynamics of phenotypic change cannot be followed, making them not suited for study highly dynamic process such as autophagosome formation. Herein, I propose to develop and use novel chemical probes to address these issues. First, I plan to prepare semi-synthetic caged LC3 proteins and apply them to monitor dynamics of autophagosome formation in the cell in order to address those questions on autophagosome formation. The semi-synthetic LC3 proteins are expected to confer a temporal control and to realize manipulation of protein structure, which renders such studies possible. Second, I intend to develop a versatile approach targeting specific endogenous proteins using a reversible chemically induced dimerization (CID) system, termed as “knock on and off” strategy. I plan to use this approach to elucidate the function of two distinct PI3K complexes in autophagosome formation. On one hand, the establishment of novel approaches will open up a new avenue for studying biological processes. On the other hand, the use of the tool will reveal the mechanism of autophagy.

Keywords: chemical biology,autophagy,chemical protein synthesis,cell imaging
A need for speed: mechanisms to coordinate protein synthesis and folding in metazoans (TransTempoFold)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2025-03-31
Duration (months): 75.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Proteins function only after folding into complex three-dimensional shapes. Loss of protein conformation is detrimental for cellular health, and a hallmark of aging and diverse human diseases. To ensure proteome integrity, cells rely on an intricate interplay between protein synthesis, folding, and quality control. Since proteins often begin to fold during mRNA translation, codon choice and tRNA supply can promote this process by modulating translation speed. How metazoans exploit this mechanism to ensure protein homeostasis over a wide range of cells and tissues, or why some cell types are more vulnerable to translation defects and proteome damage remains unknown. Here, I will define how tRNA pools and the regulatory networks for protein biogenesis and homeostasis are tailored to specialized proteomes in different cell types. I propose a multiscale systems approach centred around: i) stem cells and differentiated progeny lines as a powerful model system, and ii) a novel method to modulate cellular tRNA pools in vivo. Isogenic lines of a range of normal cellular states will be created through the differentiation of human pluripotent stem cells into neuronal and cardiac lineages. In these lineages, I will first quantitate tRNA expression and abundance, and dissect their impact on translation dynamics with ribosome profiling. Second, I will use systematic depletion of individual tRNAs to explore how different cell types respond to imbalanced tRNA pools, and define how mRNA sequence and protein structure patterns program protein folding. Third, I will use loss-of-function screens to uncover evolutionarily conserved regulators of proteome integrity as a function of cell identity. This project will define how diverse metazoan cell proteomes are established and maintained, and reveal why some cells tolerate misfolded proteins better than others.

Keywords: ribosome,trna,translation control,protein homeostasis
MULTI-FUEL HYDROGEN REFUELLING STATIONS (HRS): A CO-CREATION STUDY AND EXPERIMENTATION TO OVERCOME TECHNICAL AND ADMINISTRATIVE BARRIERS (MultHyFuel)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Germany,Belgium,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Overcoming technical and administrative barriers to deployment of multi-fuel hydrogen refuelling stations (HRS) (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2121906.25
EU funding (EUR): 1997406.25
Participants: 10
Project status: SIGNED

According to market studies scouted within the HyLaw project, by 2050 hydrogen will represent 18% of the total worldwide energy consumption. This would decrease the amount of CO2 released in the atmosphere by 6 gigatons per year and create 30 million jobs within an industry worth 2.5 trillion dollars annually. Given the systemic role that hydrogen can fulfil in integrating all energy sectors (production, transmission, storage, distribution and consumption) and the central role hydrogen can play in decarbonising our society., The need for producing, storing and distributing hydrogen in high quantities and in new locations is growing rapidly. For more efficient and lower cost hydrogen distribution, hydrogen refuelling stations (HRS) can be integrated on already existing refuelling stations. In this context, the safety recommendations for including hydrogen in a multi-fuel refuelling stations requires in depth investigation. The aim of MultHyFuel project is to contribute to the effective deployment of hydrogen as an alternative fuel by developing a common strategy for implementing HRS in multifunctional contexts, contributing to harmonize laws and standards based on practical, theoretical and experimental data as well as on the active and continuous engagement of key stakeholders. To this purpose, the project will: 1) contribute to the existing knowledge base underpinning safety rules on hydrogen dispensing by providing experimental data from engineering research and smart mitigation measures/barriers; 2) define zoning thresholds and safety requirements (e.g. separation distances, validation of safety barriers, permitting and technological requirements) based on experimental and modelling approaches, 3) contribute to the harmonization of rules applicable to HRS co-located alongside other fuels by implementing an extensive cross-country assessment of the regulation in place, performing a gap analysis, and building relevant and efficient network of stakeholders.

Keywords: multi fuel hydrogen refuelling stations,risk assessment,hydrogen releases,gap analysis,cross country analysis,practical experimentations,harmonization of safety rules,safety barriers
SMart and Interoperable THermal network system development (SMITH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain,Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The aim of SMITH innovation project is to design, develop, test under real life conditions and commercialise a novel product consisting of a Smart and Interoperable Thermal Network for micro-industrial based on biomass sources. Unique Value Proposition of the product is based on: 1) provide industrial parks with the opportunity to reduce energy costs by promoting the cascade use and the highest efficient management of the heating infrastructure; 2) combine the centralised management of the system with an application for real time decision-making of the final users (including real time consumption, invoicing, decisions about the different temperature level options, head demand planning, etc); 3) clearly foresee and plan before every product deployment the needed investment and infrastructure in order to assess the technical feasibility and profitability for both the consortium & customers; 4) design financial schemes based on energy service contracting that will avoid the industries to make investments for the new infrastructures; and, 5) reduce GHG emissions by using renewable energies in industrial networks, most of them located close to urban areas. The SMITH strength vs natural gas source are: stable and lower price, better efficiency, more sustainable and flexible, high adaptation capacity to match consumption peaks vs users’ demand, better energy and temperatures management, high control of industrial process, and stop and go more resourceful. The Feasibility Study will be focus on: a) assess the EU market needs in relation to the concrete product; b) select the countries with the best conditions to start the commercialisation of the product, and draft the business strategy for each country; c) profiling of customers in the target countries; d) obtain a direct feedback from consumers through a product concept testing; and, e) set all the critical variables needed for the go-to-market decision, the business plan and for the customer validation in Phase 2.

Keywords: industrial heating grid,smart grids,biomass,low carbon economy
Shaping a Preferable Future: Children Reading, Thinking and Talking about Alternative Communities and Times (ChildAct16)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-21
End date: 2018-08-20
Duration (months): 12.0
Total project cost (EUR): 97727.4
EU funding (EUR): 97727.4
Participants: 1
Project status: CLOSED

Despite overall agreement that children’s voices matter in the development of policies affecting them, little effort has been made to develop cultural practices encouraging utopianism as a critical attitude to reality and a means of facilitating the expression of formative opinions on the part of children. Nor have young readers’ interpretations of utopian literature been investigated as indicating their perception of the sociopolitical arrangements around them, including the context of the EU. Notwithstanding the popularity of YA dystopian fiction, little attention has been given to utopian contents in other children’s texts. A specialist in children’s literature studies and utopian studies, Deszcz-Tryhubczak addresses these lacunae in a project examining utopianism as a significant element of discourse about children, manifesting in various cultural products addressed to them. She also conducts empirical participatory research (with children as peer researchers) aimed at creating egalitarian spaces within which young readers are not only heard but also collaborate with adults towards a better understanding of how books shape ideas for the desirable future. This approach—an innovation in children’s literature studies—has a huge potential for making children’s literature scholarship relevant to young people’s lives as a cultural practice sustaining intergenerational dialogue. Thus this project is challenge-based and integrates unprecedentedly children’s literature studies, empirical studies of literature and media, utopian studies, and childhood studies. The fellow will publish its results in one article and a co-edited a collection. She will organize a colloquium for international scholars. Her stay at Anglia Ruskin will be crucial in her obtaining full professorship and in her leading a children’s literature research center in Poland. No secondment is proposed, but the research and public outreach activities provide opportunities to expose her work to the public.

Keywords: children s literature,utopianism,participatory reader response research
Regulation of synaptic development and plasticity by molecular pathways linked to human evolution (SYNPATH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-12-31
Duration (months): 67.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

Keywords: molecular and cellular neuroscience,synapse,postsynaptic scaffolds,signaling pathways,synaptic development,synaptic plasticity
Cancer Long Survivors Artificial Intelligence Follow Up (CLARIFY)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Ireland,Germany,Germany,Spain,Spain,United Kingdom,Portugal
Call: Big data and Artificial Intelligence for monitoring health status and quality of life after the cancer treatment (H2020-SC1-DTH-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 4841962.5
EU funding (EUR): 4841962.5
Participants: 13
Project status: SIGNED

There were 17 million new cases of cancer diagnosed worldwide in 2018. Survival rates of cancer patients were rather poor until recent decades, when diagnostic techniques have been improved and novel therapeutic options have been developed. It is estimated that more than 50% of adult patients diagnosed with cancer live at least 5 years in the US and Europe. This situation leads to a new challenge: to increase the cancer patients’ post-treatment quality of life and well-being. This proposal aims at identifying cancer survivors from three prevalent types of cancer, including breast, lung and lymphomas. The patient data will be collected from different Spanish hospitals and the selection will be based on ongoing health and supportive care needs of the particular patient types. We will determine the personalised factors that predict poor health status after specific oncological treatments. For this aim, Big Data and Artificial Intelligence techniques will be used to integrate all available patient´s information with publicly available relevant biomedical databases as well as information from wearable devices used after the treatment. To predict patient-specific risk of developing secondary effects and toxicities of their cancer treatments, we will build novel models based on statistical relational learning and explainable AI techniques on top of the integrated knowledge graphs. The models will utilise background knowledge of the associated cancer biology and thus will help clinicians to make evidence-based post-treatment decisions in a way that is not possible at all with any existing approach. In summary, CLARIFY proposes to integrate and analyse large volumes of heterogenous multivariate data to facilitate early discovery of risk factors that may deteriorate a patient condition after the end of oncological treatment. This will effectively help to stratify cancer survivors by risk in order to personalize their follow-up by better assessment of their needs.

Keywords: cancer survivors,breast cancer,lung cancer,lymphoma,follow up care support
Systems ITD (SYS GAM 2018)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Ireland,Italy,Italy,Italy,Austria,Germany,Ireland,Poland,Switzerland,Switzerland,Sweden,Poland,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Systems (H2020-IBA-CS2-GAMS-2017, 2017)
Start date: 2014-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 158177923.2575
EU funding (EUR): 113097530.28999999
Participants: 71
Project status: CLOSED

The Systems ITD will develop and build highly integrated, high TRL demonstrators in major areas such as power management, cockpit, wing, landing gear, to address the needs of future generation aircraft in terms of maturation, demonstration and Innovation.

Keywords: avionics,cockpit,smart actuations,more electric aircraft,eecs,power distribution,engineering based modeling,co simulation