Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reaching 25% organic farmland in the EU by stronger and better-connected organic advisors and organic advisory services (OrganicAdviceNetwork)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Sweden,Germany,Hungary,Spain,Portugal,France,Austria,Denmark,Romania,Bulgaria,Estonia,Croatia,Serbia,Slovenia,Belgium,Switzerland,Italy
Call: Developing an EU advisory network on organic agriculture (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 5272038.69
EU funding (EUR): 4998669.69
Participants: 25
Project status: SIGNED

The EU has set a target of reaching at least 25% organic farmland by 2030, which requires a tripling of the current organic area and the entry of 700,000 new farmers into the organic sector. This calls for easy access to reliable knowledge about organic practices, as well as the creation of innovations. Organic advisory services are essential to achieve this, and there is a need for 10,000-20,000 organic advisers in the EU to serve these farmers. The overall objective of the project is to co-create an EU-wide network of 1000 organic advisors that will exchange knowlegde and provide mutual support, covering all 27 EU Member States and 7 other European countries. The network will cover both plant production and animal husbandry. It will embrace the diversity of organic advisory services offered by private and publication organisations or self-employed professionals. An Action Plan will be created to ensure the long-term continuation of the network, laying down a governance structure and identifying future funding streams. Exchange will take place in online community spaces and in-person events. Online learning activities will be offered to increase technical and soft skills of advisors, both newcomers in the sector as well as more experienced organic advisors. Based on an analysis of drivers and barriers, the project will empower organic advisors to improve capacity of their organisations and promote the creation of organic advisory services where they do not exist yet. Successful business models of structuring and financing organic advisory services will be assessed. The outcomes of the project will be disseminated to actors within and beyond the organic community. Finally, synergies will be created with other EU projects and policy makers will be engaged to foster long-term support for the network itself and for organic advisory services in all parts of Europe.

Keywords: sharing of knowledge and best practices online learning co creation akis policy support peer to peer learning advisory services
Performance study of innovative Corrosion and Mechanically resistant coated materials against molten salts for next-generation concentrated solar power plants and Thermal Energy Storage systems (CoMeTES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

CoMeTES is intended to meet EU environmental concerns with the objective of spreading greener power generation systems by making concentrated solar power (CSP) technology economically viable and more secure. With a high global generating potential, CSP has emerged as a promising solution, effectively utilizing intermittent sunlight with the help of thermal energy storage systems. However, the current solar-to-electric conversion is too low due to the commonly used molten nitrates as heat transfer fluids, having limited operating temperature of 580 °C. An alternative would be to use new carbonate mixtures, able to operate at temperatures over 700 °C thereby increasing the thermodynamic efficiency. However, this would require the use of materials resistant to these conditions without increased costs. Therefore, this is CoMeTES challenge: developing low-cost and high-temperature (HT) corrosion resistant slurry aluminide coatings considering new deposition processes, and focusing on hitherto unreported mechanical and stress corrosion cracking aspects. The aim is to increase the TRL of the coating solution from 3 to 5. The project will take place at INTA, a Spanish Public Research Organization, during 24 months with a 4-months Secondment in France at EDF, the main French electric utility company, which has shown profound interest in CoMeTES related to their upcoming CSP plants projects. The applicant is adept in various technical skills in materials science including HT oxidation, corrosion, mechanics and their synergetic effects which forms the core of CoMeTES. Combined with the coating expertise at INTA, it will enable an efficient two-way transfer of knowledge and to get significant research outcomes. CoMeTES will expand the candidate’s experience in coating development and molten salt corrosion as well as large-scale project management, which along with the development of his international professional network will help him to become a distinguished researcher.

Keywords: concentrated solar power,heat transfer fluid,thermal energy storage,molten salts,high temperature corrosion,mechanics,stress corrosion cracking,slurry aluminide coatings
Validation of Magnet-Free Wireless Charging and Communication for Intra-body Devices (ARIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Türkiye,Italy
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-04-01
End date: 2024-09-30
Duration (months): 18.0
Total project cost (EUR): 167142.86
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Cochlear implants (CIs), which electrically stimulate the auditory nerve to repair hearing in people with severe-to-profound hearing loss, are used for more than 40 years. However, conventional CIs have major drawbacks, one of which is the use of magnet in the implanted unit of the CI to help perfect alignment of the coils that are used for RF Link between external and implanted units. However, using magnets prevents the CI users from accessing some of the medical treatment and examination methods like MRI, and may lead to damage on the skin. To eliminate the drawbacks of conventional CIs including the magnet utilization, we introduced FLAMENCO concept, which has demonstrated that a fully implantable cochlear implant (FICI) mimicking the natural hearing mechanism of the ear is feasible. In the ERC FLAMENCO project, we developed the FICI as a magnet-free device, which necessitated development of a novel wireless power and data transfer (WPDT) application to minimize transfer losses, thus the duration for utilization of external wireless unit to charge the implanted rechargeable battery. By introducing a unique multi-mode rectifier circuit charging the load for an extended coupling range and eliminating the requirement of alignment magnets, the efficiency loss is reduced and the charging efficiency is maximized. In the ARIA project, which stems from the developments within the ERC FLAMENCO project, we will perform technological and commercial validation of WPDT unit according to the market standards; then optimize the unit for fabricating a demonstrator to be integrated to the FICI. We will also look into the potential for integration with other Active Implantable Medical Devices (AIMDs). If implemented successfully, the ARIA WPDT not only would be a major step for commercialization of our FICI which has already triggered interest of CI makers, users and investors, but also could lead to new applications of AIMDs.
ADDRESSING MENTAL HEALTH VULNERABILITIES FROM ADOLESCENCE TO OLDER AGE: INNOVATING PREVENTION SCIENCE FOR TIMES OF CHANGE (ADVANCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Denmark,Germany,Belgium,Finland,Portugal,Italy,Lithuania,Netherlands,Switzerland
Call: Boosting mental health in Europe in times of change (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 6999987.5
EU funding (EUR): 6999987.5
Participants: 12
Project status: SIGNED

Mental health has been identified as an urgent priority in Europe, but is under critical threat because of climate change, digitalization, socio-economic inequities, migration, aging populations, and COVID-19. Protecting the mental health of vulnerable populations in these times of change requires innovative solutions beyond treatment in the clinical healthcare system. ADVANCE is a wide-ranging project which will deepen the understanding of the mental health promotion and prevention field. It will provide specific programmes which can be replicated for key groups in diverse countries in Europe and create the guidance and methodologies required to ensure that effective mental health programmes can be developed, adapted, implemented, assessed, and scaled. We propose an ambitious mixed-methods project with overarching interdisciplinary focus on social justice. Our study encompasses: (1) a rigorous co-creation process with end-users, practitioners, and policy makers; (2) an interrelated set of intervention studies with diverse vulnerable populations (from youth to old age); and (3) scaling-up strategy development. We will conduct five trials and an implementation study. Participants will be youth affected by climate change in Germany; socio-economically disadvantaged young adults in Lithuania; working adults in highly digitalized work environments in the Netherlands; migrants in Italy and Denmark; and older adults in Switzerland. All intervention studies will include adaptation through human-centred design; participatory process evaluations; stigma prevention; and scaling strategy development. We will deliver situational analyses, intervention packages, and scaling strategies in 7 countries. Based on our research across a range of developmental stages, risks, and settings we will be able to deliver 5 higher-level (synthesis) guidelines widely applicable in Europe – collected in the public-facing, openly accessible ADVANCE resource package.

Keywords: digital self help mental health promotion and prevention scaling up implementation research health inequities climate change workplace mental health migration aging
Advanced biomarker discovery for earlier diagnosis and improved prognosis of NAFLD stages via high resolution mass spectrometry. (RENAISSANCE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of nearly 25% i.e., affects one quarter of the adult population. Early phase NAFLD is reversible and can be treated, but it may progress towards life-threatening stages such as non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The conventional diagnosis of NAFLD stages requires liver biopsy and is time-consuming and costly and there is an urgent need to identify biomarkers that can be applied in routine clinical settings, such as through blood-based testing. The identification of blood biomarkers would support earlier diagnosis and improved assessment of prognosis, ultimately supporting preventive/intervention measures to avoid progression to late stage liver disease and thus saving lives. In RENAISSANCE, a state-of-the-art liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomics screening will be conducted upon the blood and blood-derived exosomes of a unique deeply phenotyped cohort of NAFLD patients for molecular biomarker discovery. Notably, exosome analysis shows promise for the identification of novel disease signatures but has yet to be applied to characterize NAFLD, providing high potential for the identification of new diagnostic/prognostic biomarkers for NAFLD. Furthermore, the LC-HRMS screen will be supported via targeted assays of redox metabolites and protein markers of acute inflammation. The integration of non-target and target data will provide insight into the underlying mechanisms of disease progression and further knowledge about potential causative factors of NAFLD.

Keywords: nafld,metabolomics,biomarker discovery,liver diseases,nash
Deciphering stem cell immunity (STEMGUARD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Stem cells guard tissue integrity by renewing the pool of differentiated cells, and must therefore be shielded from threats such as transposable elements or viruses. In that line, stem cells can largely resist viral infections, but they do so without deploying the antiviral pathways at play in differentiated cells. So, what guards the guardians? I recently discovered a stem cell-specific immune pathway, driven by a protein termed aviD (antiviral Dicer), which mounts an antiviral RNA interference (RNAi) response and thwarts RNA virus infection. This illustrates that stem cells implement specific defence mechanisms that are poorly understood, or unknown. My proposal aims at bridging the current knowledge gap in stem cell immunity. We will do so by investigating the role of the aviD pathway in vivo using an aviD knock-out mouse, as well as by unravelling the molecular regulation of the pathway (Aim 1). Stem cell’s demise can additionally be provoked by the expression of transposable elements (TEs). Converging evidence suggests that aviD and the RNAi pathway may play a second defensive role in shielding uninfected stem cells from TE expression, which we will explore in Aim 2. Because cancer is characterised by a stemness transcriptional program, aviD may similarly control TEs in tumour cells. We will study aviD expression in various tumour models and assess its role in controlling TEs. This is of special interest because awakening TE expression in cancer is being leveraged by new therapeutic approaches in multiple malignancies. Similarly, we will explore if inhibiting aviD and the RNAi pathway could have an antitumour effect (Aim 2). Finally, I hypothesize that stem cells are protected by additional, unknown antiviral pathways, which we aim to identify and characterise using new genome-scale approaches (Aim 3). Overall, this proposal aims at unveiling new biology in stem cell immunity as well as developing clinical applications in the field of antitumour therapy.

Keywords: stem cells,avid,antiviral immunity,transposable elements,tumour immunity
Multiscale observation services for mining-related deposits (MOSMIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: Germany,Sweden,Spain,Romania,Zambia,Chile
Call: Copernicus downstream applications and the European Data Economy (HORIZON-EUSPA-2022-SPACE, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3253763.75
EU funding (EUR): 2929673.38
Participants: 12
Project status: SIGNED

Our society is highly dependent on raw materials, which are currently mainly sourced by mining. Mining activities generate residues such as rock wastes, tailings and stockpiles. These materials are associated with environmental and safety risks that need to be carefully managed throughout their life cycle, with an emphasis on stability and the prevention of water and soil pollution. Earth-observation (EO)-based techniques are seldom used for monitoring these deposits, and multi-sensor field data is commonly not integrated despite recent technological advances. MOSMIN will develop holistic, full-site services for the geotechnical and environmental monitoring as well as valorisation of mining-related deposits based on a combination of EO and in situ geophysical data. We will use Copernicus EO data for large-scale monitoring of ground deformation and surface composition. Innovative change detection algorithms will highlight displacements and identify environmental hazards. Satellite data will be integrated with real-time, high-resolution data obtained from unoccupied aerial vehicles and sensors installed at the site, leveraging the power of machine learning for fusion and resolution enhancement of multi-scale, multi-source data. Novel, non-invasive geophysical techniques such as distributed fibre-optic sensing will provide subsurface information to identify resource potential, and risks such as internal deformation and seepage. In collaboration with international mining companies, MOSMIN will use pilot sites in the EU, South America, and Africa to develop and trial comprehensive monitoring services, which are calculated to have a Total Available Market of €1.2bn and expect to be commercialised shortly after project completion by three industry partners. The MOSMIN integrative service and tools will improve the efficiency and reliability of monitoring, maximise resource utilisation and help mitigate environmental risks and the impact of mining operations.
Flexible and scalable digital-twin platform for enhanced production efficiency and yield in battery cell production lines (BATTwin)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Italy,Germany,France,Sweden,Türkiye,Lithuania,United Kingdom,Hungary,Greece
Call: Advanced digital twins for battery cell production lines (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 6355218.75
EU funding (EUR): 6355218.75
Participants: 24
Project status: SIGNED

Li-ion batteries are fundamental components for the energy transition of the European eco-system. Currently Europe lags behind Asia in terms of Li-ion battery cell manufacturing and more than 90% of the world's production takes place in China, Korea and Japan. To overcome this situation, there is an ambitious ramp-up plan of 25 new gigafactories in Europe with an expected value of €35 billion by 2030. However, in the ramp-up phase of these Gigafactories, a massive production of defects is expected, between 15% - 30%. The new European Gigafactories will also bring demand for €150 bn of battery manufacturing equipment. To support this demand, the EU production equipment industry needs to fill the current knowledge gap and gain competitiveness towards Asian providers, grounding on its world-wide leadership in high-tech, green technologies, enhanced by industry 4.0 digital solutions, exploiting the European Zero-Defect Manufacturing paradigm. The objective of BATTwin is to support this scenario by developing a novel Multi-level Digital Twin platform towards Zero-Defect Manufacturing in battery production, that will reduce defect rates in battery production lines. The solution integrates four pillars, namely (i) a multi-sensor data acquisition and management layer, supported by data semantics through a Digital Battery Passport data model, (ii) process-level digital twins, modeling the critical stages of electrode manufacturing, cell assembly and conditioning through multi-physics, data-driven and hybrid approaches, (iii) system-level digital twins, based on simulation and analytical modeling, (iv) user-centric, goal-driven digital twin workflows, increasing the explainability of digital twins and driving the user in system design and control. The approach will be tested in two industrial pilots producing different battery chemistries and geometries, validating the flexibility and scaleability of the approach towards Zero Defect European Gigafactories.

Keywords: battery digital twin digital twin platform