Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sales and production acceleration of EU saffron through an innovative cultivation and crop system that allows European producers to increase eco-efficiency, production and processing (SaveEUSaffron)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of this project is to boost European produced saffron through innovative cultivation and crop system. This system is composed by two innovations, once focuses about Floating trays system cultivation and another by the automatic crop system. This global system will increase the European producers competitiveness making better quality saffron, reducing production costs and using an environmentally sustainable cultivation method, in conclusion, one more resource-efficient and sustainable saffron production and processing. Saffron cultivation and crop methods have mostly been unchanged for centuries and the need for labour is high due to the low mechanization of farms. Due to this, saffron production in European countries has shrunk dramatically during the last century. SaveEUSaffron will solve this problem by changing the current process to automate it and with more added value. The only solution to the problem is to reduce the final price of the product (through automation) and offer a better quality product (with the benefits of ecological production). This SaveEUSaffron system is innovative in the worldwide Saffron market due to its performance in connection to two operations which are currently carried out manually, and jointed are a global cultivation and crop system more effective (time and cost), with more production and processing: - Floating trays system: until the moment nobody has developed this technology for Saffron cultivation, since Saffron is very delicate plant. - Automatic crop system: CEAE has developed a machine to harvest saffron quicker than the current manual way had very good results in the tests carried out in a relevant environment (floating trays) based in the first machine. The SaveEUSaffron end-users will be all Saffron producers (as first point, European producers). The global system will reduce production costs and use an environmentally sustainable cultivation method, one more resource-efficient and sustainable method.

Keywords: saffron,production,processing,eco efficiency,innovative system
Metabolic control on NF-κB activity during dendritic cells-mediated immune tolerance to tumours (MCNTMTDC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-12-22
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

BACKGROUND: Dendritic cells (DC) are professional antigen presenting cells able to provide protective immunity to cancer. DC undergo functional maturation that can lead to tolerogenic phenotype associated with immune-suppression in cancer by a still unknown mechanism. Recently the host laboratory revealed a new role of IKKβ/NF-kB signalling in the tolergenic function of DC. However, the upstream regulators of this signalling and its implication in cancer have not yet been addressed. Since malignant cells consume high amounts of nutrients and DC become tolerogenic in low nutrient conditions possibly under the control of the master energy sensor AMP kinase (AMPK), a pseudo-starvation state in tumour-associated DC (TADC) may be responsible of their tolerogenic activity. AIMS: To determine the metabolic role of AMPK and the potential links with IKKb/NF-kB signalling in the tolerogenic activity of TADC in melanoma context. METHODS: I will use mice with a deletion of IKKβ in DC (IkbkbΔItgax) generated in the host laboratory and will generate mice with a deletion of AMPK in DC (Ampka1ΔItgax). Isolated DC will be cultured in high/low nutrient conditions or in the presence/absence of melanoma cells. Activation of AMPK and IKKβ/NF-kB signalling will be analyzed in these conditions and correlated with DC maturation. TADC will be analyzed in vivo using a mouse melanoma model with conditional melanocyte-specific expression of BRafV600E combined with PTEN deletion. The contribution of IKKβ and AMPK activation in TADC during tumour development will be assessed using (i) a skin graft model from BRafV600E mutant mice to IkbkbΔItgax and Ampka1ΔItgax mice and (ii) chimeric mice generated with bone marrow cells from IkbkbΔItgax and IkbkbΔItgax mice transferred to irradiated BRafV600E mutant mice. EXPECTED RESULTS/IMPACT: To understand the tolerogenic activity of TADC, which will give insight into potential strategies for overcoming tumour-induced tolerance in DC vaccination approaches.

Keywords: ampk,dendritic cells,ikk,nf kb,immunological tolerance,melanoma,metabolism
Quantum Broadband Optical Solid-State Memories for Large-Scale Photonic Networks (Quantum BOSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Large-scale quantum photonic networks promise to revolutionize computational processing and communication with the use of fundamental quantum-mechanical concepts. Limited by scalability, the field of quantum information processing (QIP) is so far lacking a real world, large-scale implementation that can allow for quantum computation and long distance quantum communication. These applications in QIP have distinct advantages over their classical counterparts. Quantum computation promises to provide unprecedented speed-up in processing for problems that are intractable for classical computers, while remote entanglement generation and swapping would allow long distance quantum networking. Integral to a functioning quantum network is a quantum optical memory (QM), a device allowing for the faithful storage and recall of quantum states of light using a strong and controllable light-matter interaction. The main scientific vision of this project is to develop multiple cavity-enhanced, broadband and long-lived QMs capable of long distance distribution of entanglement and multi-photon state generation. The resulting technology will provide the necessary resources for long-distance quantum communication and scalable quantum computing. The former is obtained by the heralded entanglement of two remote QMs to form an ‘elementary link’, and then swapping the entanglement between multiple links. The objective of this project is to implement the QM in a solid-state, scalable architecture.

Keywords: quantum photonic networks,quantum optical memory
Fish Flow Innovations Tidal Turbine (FFITT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Netherlands
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Fish Flow Innovations (FFI) wants to commercialize a fish friendly tidal stream turbine that converts ocean currents into electricity. The turbine can be fixed mounted on a seabed, tethered/moored to a seabed and/or buoyant, or float on the water surface or in mid water. The turbine is designed and constructed to survive in the harsh conditions offshore, and able to efficiently produce electricity in water flows between 3 and 15 m/s without the need for pitch adjustable blades for bi-directional functionality. The turbine has an integrated gravity based support structure, avoiding the need for expensive underwater support structures. The turbine can be deployed in all planned tidal locations worldwide. The main objective of the innovation project is to demonstrate and reach market readiness (TRL 9). At the end of the project (January 2019) through certification and an output performance warranty, a commercially viable levelized Cost of Energy of 10 c€/kWh will have been demonstrated in real-sea conditions (provided in the Tidal Technology Center Grevelingendam in The Netherlands).

Keywords: blue growth tidal range turbine ocean energy renewable energy manshanden fish flow innovations tidal technology center grevelingendam fish friendly
Gentrification processes and neighborhood liveability in Madrid and Brisbane: impact on population health and development of urban policy recommendations (GentriHealth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-24
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 251939.52
EU funding (EUR): 251939.52
Participants: 2
Project status: CLOSED

Where we live has a major impact on our health; indeed, 23% of global deaths are caused by modifiable environmental factors. The New Urban Agenda has inserted the ambition for liveable cities (those that promote active living and health of its citizens) as a priority to improve population health and wellbeing globally. However, liveability attributes carry a risk of ‘unintended consequences’ that can widen health inequities, especially when market-oriented regulatory processes and uneven dynamics of policy formation are at play. For instance, enhancing the liveability of a neighbourhood might increase housing prices and, in turn, provoke urban displacement of the most vulnerable, stimulating gentrification. Thus, the aim of the GentriHealth project is to generate policy-relevant evidence for the relationships between neighbourhood liveability, gentrification, and health. Specifically, the GentriHealth project has four objectives that seek to: 1. Identify gentrification-related urban planning policies and legislation in Madrid, Spain 2. Investigate the relationship between gentrification and changes in neighbourhood liveability 3. Examine how gentrification impacts the health of ‘stayers’ and ‘movers’, and whether this differs by gender and socioeconomic status 4. Work with policy-makers to develop policy-relevant solutions to reduce the potentially harmful effects of gentrification The GentriHealth project will be based at RMIT (Australia) and UAH (Spain). This project will use data on gentrification, liveability, and health from the HABITAT and the ERC-granted HeartHealthyHoods projects. This project will combine quantitative and qualitative data, mixed methods analysis ang GIS integration of data. Through a multidisciplinary approach and using a gender perspective, the GentriHealth project will generate evidence in order to develop policy-relevant solutions to allow neighbourhoods to become more liveable but not become gentrified.

Keywords: gentrifiation,liveability,built environment
Advanced Space Propulsion for Innovative Realization of space Exploration (ASPIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Innovation actions
Countries involved: Spain,Italy,Germany,Italy,Belgium,France,United Kingdom
Call: SRC - In-space electrical propulsion and station keeping - Incremental technologies (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2024-03-31
Duration (months): 39.0
Total project cost (EUR): 3717041.25
EU funding (EUR): 2999953.88
Participants: 8
Project status: SIGNED

The recent developments in high-power Hall thruster systems, thanks to the optimal combination of performance and reliability, are enabling a wide set of mission scenarios. These technological advantages, coupled with the increasing availability of power onboard satellite platforms, are encouraging several spacecraft manufacturers to focus on the implementation of high-power Hall thruster systems. The most promising scenarios envisage the introduction of a new class of service platforms characterized by versatility and a high level of reusability, the so-called Space Tug. Other applications, nowadays of particular interest, are the active debris removal to mitigate the possible collision risks. Besides, several exploration and scientific missions, such as Mars Sample Return, contemplate high power electric propulsion as the main propulsion system. Despite these potential advantages, several factors have limited the possibility of reaching qualified status for these systems, such as huge costs and availability of test facility. ASPIRE aims to increase the TRL of 20kW Hall Thruster system up to 6 by exploiting results obtained within CHEOPS. The project will cover many aspects, from mission scenarios analysis and satellite architecture consolidation to thruster unit TRL raise to 7 and enabling reduced-cost qualification. To keep operational and development costs as low as possible, krypton is maintained as baseline propellant. The ASPIRE project also aims at augmenting the numerical modelling capability necessary for qualification of high-power EP systems, which lacks in Europe. The numerical models, developed and refined by three academic partners in the frame of this project, will be validated with the data gathered in more than 1000 hours of firing with Kr. Artificial intelligence is used to develop a novel simulation-aided qualification strategy, representing an exclusive European asset for the foreseen qualification and flight in the 2020-2030 decade.

Keywords: monolithical approach,cluster approach,20 kw,high thrust,high isp,direct drive architecture
Scattering Amplitudes for Gravitational Wave Theory (Ampl2Einstein)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland,France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2372571.25
EU funding (EUR): 2297571.25
Participants: 2
Project status: SIGNED

Four years ago, the LIGO/Virgo observation of a black-hole binary merger heralded the dawn of gravitational-wave astronomy. The promise of future observations calls for an invigorated effort to underpin the theoretical framework and supply the predictions needed for detecting future signals and exploiting them for astronomical and astrophysical studies. Ampl2Einstein will take ideas and techniques from recent years' dramatic advances in Quantum Scattering Amplitudes, creating new tools for taking their classical limits and using it for gravitational physics. The powerful `square root' relation between gravity and a generalization of electrodynamics known as Yang--Mills theory will play a key role in making this route simpler than direct classical calculation. We will transfer these ideas to classical General Relativity to compute new perturbative orders, spin-dependent observables, and the dependence on the internal structure of merging objects. We will exploit symmetries and structure we find in order to extrapolate to even higher orders in the gravitational theory. We will make such calculations vastly simpler, pushing the known frontier much further in perturbation theory and in complexity of observables. These advances will give rise to a new generation of gravitational-wave templates, dramatically extending the observing power of detectors. They will allow observers to see weaker signals and will be key to resolving long-standing puzzles about the internal structure of neutron stars. We will apply novel technologies developed for scattering amplitudes to bound-state calculations in both quantum and classical theory. Our research will also lead to a deeper understanding of the classical limit of quantum field theory, relevant to gravitational-wave observations and beyond. The transfer of ideas to the new domain of General Relativity will dramatically enhance our ability to reveal new physics encoded in the subtlest of gravitational-wave signals.

Keywords: gravitational waves,scattering amplitudes,gravitational scattering
Genomic Modifiers of Inherited Aortapathy (GENOMIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1987860.0
EU funding (EUR): 1987860.0
Participants: 1
Project status: SIGNED

Thoracic aortic aneurysm and dissection (TAAD) is an important cause of morbidity and mortality in the western world. As 20% of all affected individuals have a positive family history, the genetic contribution to the development of TAAD is significant. Over the last decade dozens of genes were identified underlying syndromic and non-syndromic forms of TAAD. Although mutations in these disease culprits do not yet explain all cases, their identification and functional characterization were essential in deciphering three key aortic aneurysm/dissection patho-mechanisms: disturbed extracellular matrix homeostasis, dysregulated TGFbeta signaling and altered aortic smooth muscle cell contractility. Owing to the recent advent of next-generation sequencing technologies, I anticipate that the identification of additional genetic TAAD causes will remain quite straightforward in the coming years. Importantly, in many syndromic and non-syndromic families, significant non-penetrance and both inter- and intra-familial clinical variation are observed. So, although the primary genetic underlying mutation is identical in all these family members, the clinical spectrum varies widely from completely asymptomatic to sudden death due to aortic dissection at young age. The precise mechanisms underlying this variability remain largely elusive. Consequently, a better understanding of the functional effects of the primary mutation is highly needed and the identification of genetic variation that modifies these effects is becoming increasingly important. In this project, I carefully selected four different innovative strategies to discover mother nature’s own modifying capabilities in human and mouse aortopathy. The identification of these genetic modifiers will advance the knowledge significantly beyond the current understanding, individualize current treatment protocols to deliver true precision medicine and offer promising new leads to novel therapeutic strategies.

Keywords: modifier,thoracic aortic aneurysm,dissection
Targeting the Plant Cysteine Oxidases to Regulate Plant Stress Tolerance (PCOMOD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1995253.0
EU funding (EUR): 1995253.0
Participants: 1
Project status: SIGNED

Population growth and climate change mean that food security is an emerging global challenge. Crop loss due to flood, drought and other weather extremes is something that disproportionately affects the world's poor, but also has widespread international impact. There is an immediate and urgent need to develop tools and strategies to improve crop tolerance to such abiotic stress. One effective mechanism towards this goal is molecular engineering of crops to withstand prolonged abiotic stress. Group VII Ethylene Response transcription Factors (ERF-VIIs) have a key role in plant stress tolerance, in particular flooding but also salinity, high temperature, drought and oxidative stress. ERF-VIIs are readily degraded, but their stabilisation has led to improved flood tolerance in model plants and crops. Consequently, ERF-VIIs are focal points for engineering abiotic stress resistance in crops. ERF-VIIs are destabilised when their N-terminal cysteine (Nt-Cys) residues are oxidised, making them substrates for the N-end rule pathway of protein degradation. I discovered that Plant Cysteine Oxidase enzymes (PCOs) catalyse this oxidation, incorporating molecular oxygen into ERF-VII Nt-Cys residues to form Cys-sulfinic acid (CSA), and that PCO activity is sensitive to oxygen availability. These enzymes therefore control ERF-VII stability and mediate the response to flood-induced hypoxia. I propose generating tools and knowledge to manipulate PCO activity, modulate CSA formation and stabilise ERF-VIIs. This is an attractive and tractable strategy to enhance stress tolerance in plants. The project will require (i) the development of efficient tools and assays to detect and quantify CSA, (ii) an understanding of the breadth of PCO activity for non-ERF-VII substrates, and (iii) an understanding of the role of non-enzymatic CSA formation. This knowledge will enable the development of effective and targeted mechanisms to manipulate PCO activity and improve stress tolerance.

Keywords: enzymology,oxygen sensing,post translational modification