Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Late medieval visionary Women's IMPact in early modern Castilian spiritual Tradition (WIMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-10-14
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

WIMPACT has two main objectives. In the first place, make an exhaustive research gathering the manuscripts and early printed books on/by European Late Medieval Mystic Women (13th-14th cc.) present in Castile in the premodern period (second half 15th c.-early 16th c.) and catalogue them. In the second place, evaluate the impact that those writings had, firstly, in the Castilian religious communities affected by Ximénez Cisneros Observant reform (1492-1517) and, secondly, in the Carmelite reform, accomplished by major literary figures as Teresa de Ávila and Juan de la Cruz (second half 16th c.). The first aim will be achieved by making an in-depth search in catalogues and directly in convent libraries of Castile and other institutions with keep collections related with female monasticism. In doing this, the ER will use his philological expertise combined not only to correctly classify the books, but also to understand them in a specific reception context. The results of this first phase will be accessible by the scientific community by creating an ad hoc open access webpage. The second aim will be achieved by implementing an interdisciplinary methodology which also departs from the comparative philology, but which uses tools of different fields (especially, gender studies, sociology and religious studies) to interpret the impact of those writings had in premodern Castile. The relevance of WIMPACT for Horizon 2020 is twofold: in the first place, it implies a comprehensive, transnational perception of the cultural history of Europe, which crosses traditionally established national and chronologic boundaries. In the second, it studies the empowerment of women, their subsequent influence in the politics of the Castilian court and the role that they had in the Observant reforms undertaken in the period. Consequently, WIMPACT will provide a novel, deeper picture of the importance of the role of women in the development of European history.

Keywords: feminine literature,mysticism,tertiaries,observant reform,nunneries,mendicant movements,castilian,literature
MODELLING TOOL FOR GIVING VALUE TO AGRI-FOOD RESIDUAL STREAMS IN BIO-BASED INDUSTRIES (MODEL2BIO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Spain,Spain,Spain,Belgium,Greece,Greece,Belgium,Poland,Netherlands
Call: Model the composition of bio-based residual streams and its evolution to optimise its management and processing (H2020-BBI-JTI-2019, 2019)
Start date: 2020-05-01
End date: 2023-10-31
Duration (months): 42.0
Total project cost (EUR): 5970975.67
EU funding (EUR): 4730393.8
Participants: 14
Project status: SIGNED

Agri-food industry generates nearly 50% of the average composition of global waste in form of organic residual stream. Current management practices for waste management, including landfilling as the worst option, have to be improved to fulfil the targets of the EU. Agri-food residual streams are a potential substitute of fossil-based resources and have an important added value if used as feedstock in for the BBI, but present a high complexity and variables mixture of molecules, which makes difficult its valorisation. For this reason, the integration of a deeper knowledge on composition, logistics and volume of various organic streams could support the decision-making process to maximise profit from a specific feedstock and to select the most appropriate technologies for its optimal valorisation . The main project objective is to develop and validate at a relevant environment, the MODEL2BIO Decision-Support System tool. This will be an innovative concept that using predictive models, will estimate i) the agri-food industry residual streams composition (considering the seasonality, territorial features and origin); ii) the best recommended ways for valorising it. These recommendations will be made under a holistic perspective (technical, economic, environmental and social), with the prioritisation of the valorisation possibilities through technical and economic criteria and the final decision through holistic criteria. This innovative tool is based on the interconnection of three complementary elements: Simulation module, Optimisation algorithm and the LCA module. MODEL2BIO consortium consist on a multidisciplinary team of 11 partners from 5 different countries, covering the whole value chain and containing RTDs, universities, SMEs and clusters, and the active involvement of 27 companies providing residual streams, production process data and validating the MODEL2BIO tool. MODEL2BIO Budget is 5.970.976,16€ and request 4.730.393,8€ for funding.

Keywords: decission support tool,waste management
A new isotope-enabled climate model dedicated to polar studies, to reconstruct Antarctic climate variability and improve sea level rise projections (POLARISO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The rate of Antarctic ice loss is accelerating and reached 20% of the global sea level rise in 2012–2017. This acceleration is attributed to the coupling between atmosphere, ocean, and ice sheet dynamics. Intensive efforts are in place for modelling this complex coupled system, which is the only valid approach to improve sea level rise projections. However, the greatest uncertainty in simulating the future of the Antarctic ice sheet is due to the lack of direct observational constraints required to evaluate and improve global climate models. The isotopic signals contained in Antarctic ice cores have high potential to record the climate variability of recent centuries as water stable isotopes are tracers of the whole water cycle pathway. However, linking the isotopic signal to climate patterns requires to use isotope-enabled climate models, which are currently limited by their poor skills in simulating polar-specific processes. The POLARISO project aims to overcome this major limitation by implementing water stable isotopes in a polar-oriented regional climate model, which will be evaluated with new isotope observations in Antarctica. We will then use the validated simulations to identify large scale drivers of the isotope variability at the Antarctic surface. This project is based on a synergy between advances in Antarctic climate modelling (PI) and advances in continuous measurements of water isotopes in water vapor and precipitation in Antarctica (host). The POLARISO project will provide robust transfer functions between climate modes and water isotope variability, which will open doors for new climate reconstructions based on water isotope measurements in Antarctic deep and shallow ice cores. It will also enable the PI to reach an independent leading position by developing an internationally unique expertise on polar regional modelling equipped with water isotopes, dedicated to model-data studies.

Keywords: antarctica,climate reconstruction,water stable isotopes,regional climate modelling,polar processes,water cycle,model evaluation,sea level
Piloting cascaded continuous flow synthesis for the pharmaceutical industry (PICASCO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

PICASCO aims to deliver the commercial proof of concept of a novel endto- end flow manufacturing and a novel corresponding compact flow mini plant. This is performed through the first continuous 4-step solvent-free flow manufacturing of a pharmaceutically relevant API compound at an industrial scale. Currently applied batch manufacturing techniques leave much room for improved quality, efficiency, cost-effectiveness and environmental friendliness. Flow multi-step manufacturing can address all these issues simultaneously, but to date has not been brought to an industrially useful scale. PICASCO sets out to scale this final barrier.

Keywords: continuous flow synthesis
The world's first Sensor-Based Water Filter to Purify and Analyse Tap Water (TAPP X)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 1771350.0
EU funding (EUR): 1239945.0
Participants: 1
Project status: CLOSED

Magnus Jern and Alex Schwartz founded TAPP Water in 2014 and since then have tested over 50 different filters and technologies, while conducting blind tests among test panels and installation tests and analysis by water institutes. Based on our findings, we developed a new filter system that provides the cleanest and best tasting tap water in the world: TAPP, combining the best of Scandinavian design, German engineering and Spanish water filtration expertise. For now, our short term goal is to lower the environmental impact of clean drinking water and replace at least 1 Billion bottles by 2020 by empowering people to easily get clean and healthy water from tap. To achieve this goal, we have already sold two tap filters (TAPP 1 and 1S) in 5 countries, while TAPP 2 is being prepared for launch in June 2018. TAPP X is the world’s first household water filter that contains sensors to analyse tap water quality in real time. With TAPP X we intend to alter consumers’ behaviour once and for all by taking away prejudices about (filtered) tap water in the form of an evidence-based approach. In addition, we will use this data to inform water providers and municipalities about tap water quality in their area. TAPP X is the next step in providing affordable, clean drinking water to all, while creating awareness about water consumption and battling harmful plastic waste. With an estimated 1 Billion households worldwide having access to tap water, we initially target about 62 Million households in Europe and North America with TAPP X. Successful implementation and of TAPP X in our current portfolio of water filters by 2021 will boost our company not only financially, but also create new positions, further enhance tap water quality and reduce plastic bottle waste with 2 Billion bottles per year.

Keywords: water filter,single use plastic reduction,internet of things,big data,water quality
Testing the Evolutionary Consequences of Haploid Selection in Animals (SELECTHAPLOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2122476.0
EU funding (EUR): 2122476.0
Participants: 1
Project status: SIGNED

Selection occurring during the haploid gametic phase of any sexually reproducing eukaryote may have far-reaching consequences for major biological processes. Selection acting on a haploid genome results in efficient removal of deleterious alleles and rapid fixation of beneficial alleles, which in turn affect adaptation, genetic load and the evolution of recombination rates. Despite their potential importance, we know surprisingly little about the genetic processes occurring during the time window after meiosis until the fusion of male and female pronuclei. This is particularly true for haploid selection in the gametes of predominantly diploid animals. Male gametes (sperm) are produced in vast numbers but only few fertilise eggs and therefore offer a strong opportunity for selection. A prevailing view that such haploid selection is of minimal consequence in animals has been recently overturned by evidence from our lab, which revealed strong links between sperm phenotype and offspring fitness, as well as sperm phenotype and its haploid genotype. The genetic mechanisms underlying these observations are currently poorly understood. In this project, I will tackle three key questions arising from these recent findings: i) How strong are purifying and positive selection during the haploid phase? ii) What are the mechanisms maintaining genetic variation in genes expressed during the haploid phase? iii) How does haploid selection affect the interaction between male and female gametes? By combining carefully designed innovative experimental approaches with cutting-edge single-cell genome and transcriptome sequencing technologies, this project will provide entirely novel insights into the process that is shared by all eukaryotic life. Findings from this project will illuminate not only the fields of evolutionary biology and genetics but far beyond into the areas of animal breeding and human reproduction.

Keywords: haploid selection,biphasic life cycle,genomic conflict,sexual reproduction
Circuit mechanisms underlying sensory-evoked navigation (EXPLORATOME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Life-threatening cues such as the scent of smoke or the taste of rotten food cause avoidance behavior in animals. In such situations, instantaneous integration of relevant sensory inputs by motor centers that guide navigation can be a matter of life and death. How is this sensorimotor integration achieved? In vertebrates, it is known that motor command centers in the brainstem receive direct inputs from higher brain areas and cutaneous sensory pathways and in turn control the spinal circuits that drive locomotion. It is less well understood whether these brainstem command neurons are simple integrators relaying information, or whether they add a layer of integration to select locomotor action sequences. Because brainstem neurons are difficult to visualize and access in mammals, it has been challenging to measure their activity in moving animals as they respond to sensory cues. In contrast, larval zebrafish is a simpler vertebrate model in which optical technologies can be leveraged to visualise, record, and manipulate any and/or all brainstem neurons during locomotion. This project will decode the neuronal computations of descending command neurons that integrate sensory inputs and elicit locomotor actions in freely-moving zebrafish larvae. To this end, my group has designed an unbiased method for segmenting locomotor action sequences from noisy behavioral data. Applied to robust assays where larvae navigate in chemical gradients, we are now in a unique position to link locomotor action sequences to the sensory landscape fish perceive. This original approach, together with innovative technologies pioneered in my lab, will reveal brainstem neuronal connectivity and roles in the selection of locomotor sequences. The EXPLORATOME project will lead to models of circuit computations in the brainstem, a brain region historically-overlooked and with high potential for targeted electrical stimulations in patients with motor disorders.

Keywords: brainstem,reticulospinal neurons,locomotor action sequences,exteroception,proprioception,navigation,zebrafish
Multiscale design of porous implants with a biomimetic functionally graded cellular material (MIDPOINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-02
End date: 2023-11-01
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Endosseous implants are now widely used in clinical practice to restore joint functionality or to replace missing teeth. Despite their increasing success, implant long-term stability remains a concern and it is difficult to predict the surgical outcome so far. A major cause of failure comes from bone resorption secondary to stress shielding, which arises from the mismatch of the mechanical properties between the implant and the surrounding bone tissue. To overcome this problem, MIDPOINT proposes to design porous implants that will have a biomimetic cancellous bone microstructure with a nonhomogeneous distribution of its material properties. The optimal design will produce implants with mechanical and microstructural properties similar to that of the bone, which will result in an improvement of the effectiveness of osseointegration phenomena. A work methodology that combines multiscale computational modelling and experimental work for the formulation, construction, verification and validation of computational models is proposed. This methodology will comprise i) the design of new biomimetic microstructures that replicate the geometrical properties of the natural trabecular bone using a generative design approach, the Voronoi tessellation approach; ii) the development of an iterative computational method to predict the fatigue life of the artificial microstructures directly at the macroscale employing damage accumulation models coupled with artificial neural networks; and iii) the construction of multiscale models of bone-implant systems to optimize the implant microstructure locally in order to achieve a desirable mechanical response and functional environment for bone ingrowth and, therefore, minimize bone resorption. These techniques will be employed to design implants and scaffolds that, together with medical imaging techniques, can be personalized to the needs of each patient and directly printed at the medical institution using additive manufacturing techniques.

Keywords: biomechanics,bone,implant,osseointegration,stress shielding,multiscale,modelling,optimization,additive manufacturing,biomimetic microstructures,fatigue failure,neural networks
New generation of low-cost Lateral Flow Assays (LFAs) coupled with paper-based electrical gas sensors: An application study for the rapid determination of Salmonella in food (NELLAFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: SIGNED

Over 420,000 people die each year due to contaminated foodstuffs, with Salmonella identified as one of the key global causes. Yet conventional methods for the determination of Salmonella in food require several enrichment and subculture steps performed by trained staff at lab-based facilities, taking up to 5 days to obtain a result. Lateral Flow Assays (LFAs) have emerged as a powerful alternative method for Salmonella testing because they are rapid, simple-to-use and amenable for Point-of-Need (PoN). However, current LFAs available in the market only provide binary (yes/no) or semiquantitative responses, lacking the rapidness and sensitivity required for food monitoring due to the limitations of the colorimetric transduction. By the integration of paper-based electrical gas sensors (PEGS) as detectors into Lateral Flow Assays, NELLAFLOW will address the challenge of quantitative determination of Salmonella in food without the requirement of long enrichment steps. PEGS have already proven to be highly sensitive towards water-soluble gases determination. They exploit the intrinsic hygroscopic characteristics of cellulose paper and the changes in its ionic conductance in the presence of water-soluble gases. The incorporation of aptamers as biological recognition elements in the PEGS-LFA platform will improve the implementation of the prototype for on-site monitoring as they are low-cost, highly specific, and stable at room temperature. Through a multidisciplinary approach (biomolecular engineering, analytical chemistry, printed electronics, microbiology) NELLAFLOW will tackle a problem in the food industry with an innovative versatile technology that can be easily transferred to other application fields. By combining academic and non-academic training, NELLAFLOW will broaden the Fellow expertise through new technical and management skills that will complement her previous experience while delivering high impact results and transfer of knowledge.

Keywords: paper based electrical gas sensors pegs,lateral flow assay lfa,aptamers,salmonella,bacteria,food safety