Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic and Environmental Variation of Memory phases (GEVM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 534000.0
EU funding (EUR): 534000.0
Participants: 1
Project status: CLOSED

Memory (i.e. the ability to store and retrieve information) plays a crucial role in the development of an animal’s behavior within its lifespan and is often important for its survival and reproductive success. Memory is itself a product of evolution and the degree to which information is maintained in the brain varies among species and among different types of behavior. Findings from vertebrate behavioral pharmacology have challenged the traditional view of memory formation as a direct flow from short-term to long-term storage. Evidence points instead to an intricate, multiphase pathway of memory consolidation. Different components of memory emerge at different times after the event to be memorized takes place. In addition, their duration and times of onset can vary with different tasks and species If variations in memory capacities have been observed among closely-related species, the relationship between environmental conditions and evolution of these capacities have only been rarely studied despite the importance of this topic in the understanding of the evolution of behavior. I propose an experimental approach using Drosophila as a model system. This project concentrates on: Part 1: Genetic variation of the memory phases Part 2: Effect of the environmental conditions on the development of memory Part 3: fitness cost of memory Part 4: Consolidation, Reconsolidation and Extinction: similar or separate processes?

Keywords: evolution of memory phases
Cell polarization in Drosophila (CEPODRO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 1159000.0
EU funding (EUR): 1159000.0
Participants: 1
Project status: CLOSED

Cell polarity is fundamental to many aspects of cell and developmental biology and it is implicated in differentiation, proliferation and morphogenesis in both unicellular and multi-cellular organisms. We study the mechanisms that regulate cell polarity during both asymmetric cell division and epithelial cell polarization in Drosophila. To understand these fundamental processes, we are currently using two complementary approaches. Firstly, we are coupling genetic tools to state of the art time-lapse microscopy to genetically dissect the mechanisms of cortical cell polarization and mitotic spindle orientation. Secondly, we are introducing two innovative inter-disciplinary methodologies into the fields of cell and developmental biology: 1) single molecule imaging during asymmetric cell division, to unravel the mechanism of polarized protein distribution within the cell; 2) multi-scale tensor analysis of epithelial tissues to describe and understand how epithelial tissues grow, acquire and maintain their shape and organization during development. Using both conventional and innovative methodologies, our goals over the next four years are to better understand how molecules and protein complexes move and are activated at different locations within the cell and how cell polarization impacts on cell identities and on epithelial tissue growth and morphogenesis. Since the mechanisms underlying cell polarization are conserved throughout evolution, the proposed experiments will improve our understanding of these processes not only in Drosophila, but in all animals.

Keywords: cell polarization,drosophila,asymmetric cell division,epithelial tissue
Joint assimilation of satellite aerosol, cloud, and precipitation observations in numerical models to support climate and hydrologic applications (JOINT-ASSIMILATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-05-01
End date: 2012-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Clouds and their interaction with radiation represent one of the largest uncertainty in climate and weather prediction. This is because clouds result from processes and depend on variables such as aerosols that have not comprehensively observed until recently. The advent of the satellite technology made possible the continuous monitoring of clouds and related variables from space. Our primary research objective is the use of existing satellite aerosol, cloud and precipitation observations to gain insight into cloud processes and their impact on climate and weather. Specifically we intend to assimilate satellite observations into a state of the art cloud-resolving atmospheric model. This will facilitate a better analysis of the interaction between clouds and large scale processes and allow for the development of better cloud microphysical schemes. Based on the analysis, the impact of aerosol of climate and weather will be rigorously assessed. The project will also facilitate the re-integration of Dr. Mircea Grecu into an European Research Institution. The Hellenic Center for Marine Research is commited to support this re-integration by offering Dr. Grecu a four-year long appointment.

Keywords: natural sciences,atmospheric physics (climate change),aerosols (climate change)
Enabling Architecture Based Verification and Validation of Mission-Critical Systems (ABV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-09-01
End date: 2012-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Software is ubiquitous in the world we live in today, enabling the successful operation of systems ranging from every day appliances like microwave ovens, to complex mission critical systems like financial transaction management systems, fly-by-wire and drive-by-wire control systems and air traffic management. This ubiquitous use of software highlights the fact that the quality of the software is a direct determinant of the end success of the implemented system. V&V activities are crucial to the design, development and sustainment of mission-critical systems. In addition to accounting for a significant portion of both the cost and schedule aspects of the system lifecycle, V&V forms the basis for providing increased confidence in the fielded system. The high level objective of this project is to reduce the cost and schedule dimensions of mission critical systems development, while at the same time increasing confidence in the implemented system. . The approach adopted in this proposal, involves establishing traceability across pre-implementation artefacts such as the requirement specification, architecture specification and the implemented system. We will carry out fundamental research in defining formal semantics for the Advanced Architecture Description Language, and create algorithms to support specification based test case generation. The project will expand the theory base, and support active transfer of knowledge to Industry.

Keywords: computer engineering,software technology,specification languages,verification and validation,specification-based testing,traceability,formal methods,mission-critical systems
Alternative Regionalisms in an Age of Globalization. The Role of Civil Society (ALTERNATIVE REGIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2007-09-01
End date: 2009-08-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Recently, economic liberalization emphasis on regionalism has been a prime concern for wider sectors of civil society around the world. Over and over, these groups are presented in the mass media as opponents to this policy option. Less has been said about the alternatives they have put forward. This research focuses on this task and in so doing; it develops a systematic and comparative South-South analysis of: a) key initiatives promoted by civil society groups in Latin America as alternatives to overcome socio-economic deficits embedded in contemporary regionalism; and b) practices of governance that are emerging for the implementation of these alternatives. Therefore, this project advances my previous research findings on gender, trade and democracy and identifies concrete forms in which economic liberalization, gender inequalities and the lack of citizen participation (particularly of elderly, poor, disable and indigenous women) are inextricably related at sub-regional level. Based upon an action-oriented research methodology and incorporating intersectoral exchanges between civil society and the academic sector in Europe and Latin America, this study’s contributes to: 1. Bring together the literature on the politics of alternative development, feminist economics and regional studies within IPE for the comparative and systematic analysis of alternative regionalisms 2. Provide an updated and comparative assessment of concrete practices of alternative regionalisms in Latin America in which greater levels of subsidiarity in decision-making has (or has not) been successfully promoted. 3. Explore concrete cases of civic activism in relation to three official mechanisms of regional governance that involve Northern and Southern counterparts: the European Union New Strategic Partnership for Latin America and the Caribbean (EU-LAC), the Free Trade Area of the Americas (FTAA) and the Security and Prosperity Partnership of North America (SPP/NAFTA plus).

Keywords: governance,involving society,gender studies,equal opportunities,regional policy maker,social changes,socio-economic research,development studies,political economy,social sciences
Compartmentalization and dynamics of Nuclear functions (CDNF)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2014-05-31
Duration (months): 69.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

The eukaryotic genome is packaged into large-scale chromatin structures that occupy distinct domains in the nucleus and this organization is now seen as a key contributor to genome functions. Two key functions of the genome can take advantage of nuclear organization: regulated gene expression and the propagation of a stable genome. To understand these fundamental processes, we have chosen to use yeast as a model system that allows genetics, molecular biology and advanced live microscopy approaches to be combined. Budding yeast have been very powerful to demonstrate that gene position can play an active role in regulating gene expression. Distinct subcompartments dedicated to either gene silencing or activation of specific genes are positioned at the nuclear periphery. To gain insight into the mechanisms underlying this sub-compartmentalization, we will address three complementary issues: - What are the mechanisms involved in the establishment and maintenance of silent nuclear compartments? - How and why are some activated genes recruited to the nuclear periphery? - What are the relationships between repressive and activating nuclear compartments? Concerning the maintenance of genome integrity, recent advances in yeast highlight the importance of nuclear architecture. However, how nuclear organization influences the formation and processing of DNA lesions remain poorly understood. We will focus on two main questions: - How and where in the nucleus are double strand breaks recognized, processed, and repaired? - Where do breaks or gaps resulting from replicative stress at 'fragile sites' arise in the nucleus and how does nuclear organization influence their stability? We hope to gain a better understanding of the mechanisms presiding nuclear organization and its importance for genome functions. These mechanisms are likely to be conserved and will be subsequently tested in higher eukaryotic cells.

Keywords: chromatin,epigenetic,nuclear organization,transcription,genome stability
Identification and toxic potential of Cyanoprokaryota in the Bulgarian water bodies. Environmental health risks. (CYANOIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Bulgaria
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2007-10-01
End date: 2011-01-15
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Blue-green algae (Cyanoprokaryota) are increasingly gaining importance in view of health hazards and ecological risks caused by secondary metabolites with toxic properties named “cyanotoxins”. More than 40 Cyanoprokaryota species are capable to form blooms and produce cyanotoxins. The most common and well-studied producers of cyanotoxins are Microcystis aeruginosa, Aphanisomenon flos-aquae, Anabaena flos-aquae, Cylindrospermopsis raciborskii, Planktothrix agardhii, Lyngbya majuscula, Nodularia and Oscillatoria. Yet, Cyanoprokaryota, often detected in the Bulgarian water bodies, are not studied in toxicological aspects. Therefore, the main goal of this project on the one hand is to identify and characterize the blue-green algae distributed in different Bulgarian freshwater bodies (especially those used for potable and recreational purposes as well as fish-ponds) and on the other hand, to examine their ability to produce intracellular and extracellular toxins. Also, implications on human health and ecological risks caused by harmful freshwater algal blooms will be evaluated and perilous water bodies will be noted and mapped. Correlation between the capacity of toxin production and different environmental factors will be analyzed by ecological models as well as mimicking some environmental factors in in vitro conditions. Collected cyanoprokaryotic samples will be identified by the classical morphological method and if it is necessary by molecular-genetic methods. Determined Cyanoprokaryota species will be adjusted for in vitro culturing and used to study their toxic potential. The toxicity of algal extracts and collected natural water samples will be tested by combination of different in vitro biological assays (enzymatic activity, viability of different cell lines) and the toxins will be identified using ELISA and HPLC methods.

Keywords: biodiversity inventory: systematics phylogeny taxonomy,ecotoxicology,water quality monitoring,environmental risk assessment,health and environment (environmental protection)
Advanced Safety Assessment Methodologies : level 2 PSA (European Best Practices L2 PSA guidelines) (ASAMPSA2)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Coordination and support actions
Countries involved: France,Germany,Hungary,Belgium,Spain,Czechia,Finland,Italy,Germany,United Kingdom,France,Netherlands,Germany,Switzerland,Sweden,Sweden
Call:  (FP7-Fission-2007, 2007)
Start date: 2008-01-01
End date: 2011-12-31
Duration (months): 48.0
Total project cost (EUR): 2112056.6
EU funding (EUR): 1499998.0
Participants: 23
Project status: CLOSED

The objective of this coordination action is to develop best practice guidelines for the performance of Level-2 PSA methodologies with a view to harmonization at EU level and allowing a meaningful and practical uncertainty evaluation in a Level-2 PSA. Speficic relationships with community in charge of nuclear reactor safety (utilities, safety authorities, vendors, research or services companies) will be established in order to define the current needs in terms of guidelines for level 2 PSA development and applications. A technical group of level 2 PSA experts from project partners will propose guidelines for a limited-scope and a full-scope L2 PSA based on practical experience of each partner. Elaboration of this guidelines for operating plants will be the main activity of this coordination action. This guideline will be discussed with End-Users community and their opinion will be taken into account in the final version. The applicability of such a guideline for future reactor (Gen IV) will be also examined.

Keywords: level 2 psa,best practices guidelines,end users
Multi-source Energy Storage System Integrated in Buildings (MESSIB)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Spain,Spain,Germany,Slovenia,Italy,France,Netherlands,Germany,Germany,Poland,Greece,Spain,Germany,Finland,Italy,Netherlands,Spain
Call:  (FP7-NMP-2007-LARGE-1, 2007)
Start date: 2009-03-01
End date: 2013-02-28
Duration (months): 48.0
Total project cost (EUR): 8541600.52
EU funding (EUR): 5990695.05
Participants: 24
Project status: CLOSED

The overall objective of MESSIB is the development, evaluation and demonstration of an affordable multi-source energy storage system (MESS) integrated in building, based on new materials, technologies and control systems, for significant reduction of its energy consumption and active management of the building energy demand. This new concept will reduce and manage smartly the electrical energy required from the grid favouring the wider use of renewable energy sources . It will reduce raw material use for thermal performance and improve the indoor environment, the quality and security of energy supply at building and district level, including Cultural Heritage buildings. Furthermore, a significant reduction of the energy unit cost for end-users will be achieved. MESS is composed by two thermal and two electrical storage systems, integrated with the building installations and a control system to manage the building energy demand. The MESSIB basic principles are: 1.Rational use of thermal energy for primary energy savings and for increasing the indoor comfort. 2.Improvement of electrical energy storage in combination with RES to shift the demand with the production and to optimise the use of low cost “off peak” power from the grid. 3.Integration of the technologies in the building. Each of the technologies developed in the project will be integrated with conventional installations optimizing their functionality. 4.An active control system will manage the profile of use of each storage system and their interactions. This will contribute to the intelligent management of building energy demand and to ensure its security, quality and reliability.

Keywords: thermal,electrical,storage,energy,demand,reduction,system,raw materials,business model,phase change,ground,flywheel,redox flow battery,control
Coordination Action for Research Activities on Life in Extreme Environments (CAREX)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Sustainable management of resources
Action type: Coordination and support actions
Countries involved: United Kingdom,France,Italy,Germany,France,France,Czechia,Spain,Iceland
Call:  (FP7-ENV-2007-1, 2007)
Start date: 2008-01-01
End date: 2011-06-30
Duration (months): 42.0
Total project cost (EUR): 1378881.52
EU funding (EUR): 1199524.14
Participants: 9
Project status: CLOSED

Life in Extreme Environments (LEXEN) is an emerging area of research in which Europe has considerable expertise but a relatively fragmented research infrastructure. The science of such environments has enormous relevance for our knowledge of the diversity and environmental limits of microbial, plant and animal life and the novel strategies employed for survival and growth. Such studies are essential in understanding how life established on the early Earth and in assessing the possibilities for life on other planetary bodies. These environments are also a rich source of novel exploitable compounds. The Work Programme identifies a need for better coordination of LEXEN research and CAREX aims to address this need by developing a clearly identifiable, dynamic and durable community. Establishing this community will encourage greater inter-disciplinarity and increasing knowledge of extreme environments. It will provide a target for young career scientists and allow a more focussed dialogue with other science areas, with funding agencies, with industrial groups and with international organisations outside Europe. CAREX deliverables will include a strategic roadmap for European LEXEN research (including enabling technologies), diverse opportunities for knowledge transfer, standardisation of methodologies, encouragement and support for early career scientists and a network of links to relevant organisations. These deliverables together with improved community networking, supported by newsletters, promotional leaflets, a series science publications and an interactive web portal, will help consolidate the community and its identity. Outcomes will be facilitated through science/technology workshops, diverse forums, field/laboratory protocol intercomparisons, a summer school and individual grants to facilitate knowledge transfer. CAREX has evolved with the key players from the highly successful ESF “Investigating Life in Extreme Environments” initiative .

Keywords: extreme environment,biodiversity,model ecosystem,model organism,enabling technologies