Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the roles of chromatin modifiers in germline aging (Egg-Juvenate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

Faithful transfer of genetic material is critical for the success of all cell divisions. Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes. This can lead to cancer in mitotic cells, and in the female germline it leads to reduced fertility and exponential increase in miscarriages and birth defects already at the third decade of life. In humans, all the oocytes begin their development in-utero but arrest for decades in the middle of this process leading to the rapid increase in meiotic divisions failure. The oocytes arrest while undergoing dramatic structural changes, termed chromosome remodelling. Very little is known about what drives this critical phase in germline development, yet it is assumed to involve chromatin modifiers and DNA binding complexes. I propose to identify chromatin-modifying complexes that act in chromosome remodelling and find their mechanism of operation. This will be achieved by utilizing my recently developed technologies and RNAi screen results, which gives me unique tools and approaches to study this complex process. This research will open the window into the connection between chromatin modifiers that facilitate chromosome restructuring and germline aging. The research is aimed to find the major players in this processes and their mode of operation. In an age where maternal age is rising in the western world, translational implementation of this research would have a dramatic impact on our scientific understanding of fertility.

Keywords: fertility,meiosis,germline,chromosome dynamics
redTADF (redTADF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Adachis pioneering report in 2012 describing TADF emitters based on CDCBs resulted in a paradigm shift in emitter design within the OLED community. Within just five years, highly efficient blue and green purely organic TADF OLEDs have been developed, achieving maximum EQEs exceeding 30%. This means that performance wise, organic TADF emitters have already surpassed the performance of state-of-the-art phosphorescent molecules. However, to date only a handful of red organic TADF emitters exist, with the best EQE reported to date being just 13%, demonstrating a need for continued improvement. European companies such as CDT, Merck, and Cynora are all investing significantly in organic TADF research. The development of high performance organic redTADF emitters will significantly reduce the cost of OLED production and make the devices more environmentally friendly through replacement of the iridium emitters that are currently employed. We propose to develop new highly efficient redTADF dyes based on the ring-contracted systems of subphthalocyanine and subporphyrin.

Keywords: organic light emitting diodes oleds,thermally activated delayed fluorescence tadf,redtadf oleds,boron subphthalocyanine,subporphyrin
AN INNOVATIVE METHOD TO DESIGN 100% PERSONALIZED PROGRESSIVE LENSES (ERGOFOCUS SYSTEM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Presbyopia is a progressive loss of near vision that occurs in people after the age of 40. Presbyopia is caused by the irreversible, age-dependent weakening of the ciliary muscles that allow us to focus on objects that are close to us or far away. In presbyopia patients the eye lens loses its ability to round up to focus on near objects. Almost 2 billion people are affected by presbyopia all over the world. In Europe over 209 million people suffer it, 44% of the total population. Unfortunately, this percentage will keep increasing to reach 50% by 2030. From an economic perspective, only in the US the loss of productivity caused by presbyopia in 2011 amounted to $11B. Progressive lenses are the best solution to correct presbyopia because they provide clear vision at all distances. However, they need to be tailor-made, significantly increasing their price. Moreover, these lenses introduce distortions in the vision and require a long habituation time to be used comfortably. These flaws are intrinsic to the current methods of designing lenses, that do not consider optical and anatomical characteristics of every user; instead they estimate them using standard values. Lentitech, a start-up company funded in Spain, patented a solution to design 100% personalized progressive lenses. ErgoFocus is composed of a measuring device that takes measurements of the user’s facial and optical parameters, a software that interprets the data and a set of advanced algorithms that design progressive lenses based on these measurements. The Ergofocus design shortens the habituation time and minimize visual aberrations. Our product has a great opportunity of successful commercialization because the number of users of progressive lenses is increasing exponentially as the global population ages. As a matter of facts, the global eye glasses and contact lenses market, is expected to generate revenue of $72.60B by 2023 and progressive eye glasses capture more than 60% of the total market.

Keywords: presbyopia,optometry,progressive lenses,personalized lens design
KEEPING YOUR CONNECTED SMART DEVICES PROTECTED AGAINST HACKERS AND CYBER ATTACKS (ELIoT Pro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 2827625.0
EU funding (EUR): 1979337.5
Participants: 1
Project status: CLOSED

Cyberus Labs is developing a novel cyber security platform for ultra-secure Internet of Things (IoT) networks. Currently, IoT is the wild west of cyberspace. Secure IoT is an urgent need in numerous industrial sectors. 48% of companies using IoT have been affected by breaches with detrimental impact on revenue and reputation. Cybersecurity is one of the main drivers of the IoT market growing at a CAGR of 44% but current solutions fail to provide needed protection. Strong IoT cybersecurity needs to eliminate all exploitable weak points that can be used for user and IoT device identity theft, device takeover, data theft, DDoS, cloning and Man-in-the-Middle attacks, being scalable and suitable for even the simplest devices e.g. sensors. Passwords and actionable credentials for Human to Machine (H2M) and Machine to Machine (M2M) authentication in IoT are the weakest link in cybersecurity today and credentials theft is a huge global problem. For users, passwords are a frustrating experience and for business a major cybersecurity risk. The solution: ELIoT (Easy&Lightweight IoT Protector) – an end-to-end cybersecurity solution for IoT networks. For H2M authentication in IoT environments the solution eliminates passwords – nothing for hackers to steal. Our core technology is based on the One-Time Password (OTP) user authentication protocol, mathematically proven unbreakable. For M2M in IoT environments ELIoT Pro ensures secure device-to-device authentication and data security using a lightweight encryption protocol. Unlike other crypto methods it is suitable for even simple sensors and saves battery power, which extends device lifespan. Our system is universal, easy to deploy, easy to use and ultra-secure. It is highly compatible with the growing trend of voice-controlled IoT hubs e.g. Alexa. Our 5 global technology partners are eager to license and integrate ELIoT into their IoT products, spreading its use in various IoT markets and driving company growth.

Keywords: cybersecurity,user and device authentication,lightweight encryption,smart cities,connected and autonomous cars,sensors,software,saas,alexa,watson,passwords,voice controlled,network
Highly EFFICIENT and reliable electric drivetrains based on modular, intelligent and highly integrated wide band gap power electronics modules (HiEFFICIENT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Italy,Italy,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Italy,Belgium,Slovakia,Türkiye,Belgium,Belgium,Slovenia,France,Netherlands,Netherlands
Call: ECSEL-2020-2-RIA (H2020-ECSEL-2020-2-RIA-two-stage, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 42.0
Total project cost (EUR): 41893118.36
EU funding (EUR): 11936415.58
Participants: 33
Project status: SIGNED

The European “Green Deal” initiative by the EU commission strives for sustainable mobility and efficient use of resources. Within HiEFFICIENT the project partners will work towards these goals and will develop the next generation of wide band-gap semiconductors (WBG) in the area of smart mobility. To boost this development and the market introduction in automotive applications, HiEFFICIENT partners have set ambitious goals to gain higher acceptance and achieve the maximum benefit in using WBG semiconductors: 1.) Reduction in Volume of 40%, by means of integration on all levels (component-, subsystem- and system level), 2.) Increase efficiency beyond 98%, while reducing losses of up to 50%, 3.) Increase reliability of wide band-gap power electronic system to ensure a lifetime improvement of up to 20%. To accomplish the targeted goals, the partners will work on industrial use cases to demonstrate the key achievements and the progress that goes beyond state of the art. This includes, amongst others, modular inverters with different voltage levels (such as 48V, 400V, 800V), flexible on- and multi-use off-board chargers for different voltage levels, multi-purpose DC/DC converters and test systems for power electronics’ lifetime testing. These use cases are led by OEMs and other industrial partners, who define requirements and specifications for the envisioned systems. The project work starts at component-level, developing highly integrated GaN and SiC devices, and is followed by multi-objective design optimization and virtual prototyping approaches. High integration means big challenges in thermal management, which will be addressed by the development of advanced cooling concepts and modularity for the sake of maintainability and flexibility for future applications. Finally, the demonstrators are integrated in relevant environments to proof the concepts and the applicability for electric drivetrains with higher integration, higher efficiency, and higher reliability.

Keywords: smart mobility,wide band gap,efficiency,integration,reliability
FREE and open source software tools for WATer resource management (FREEWAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Coordination and support actions
Countries involved: Ukraine,Germany,Germany,Estonia,Italy,Spain,Spain,Italy,Malta,Switzerland,Türkiye,Greece,Romania,Slovenia,France,Czechia,Netherlands
Call: Dissemination and exploitation, ICT, knowledge, gaps, research needs, etc (H2020-WATER-2014-one-stage, 2014)
Start date: 2015-04-01
End date: 2017-09-30
Duration (months): 30.0
Total project cost (EUR): 1583912.5
EU funding (EUR): 1411162.5
Participants: 20
Project status: CLOSED

FREEWAT aims at promoting water management and planning by simplifying the application of the Water Framework Directive and other EU water related Directives. FREEWAT will be an open source and public domain GIS integrated modelling environment for the simulation of water quantity and quality in surface water and groundwater with an integrated water management and planning module. Specific objectives of the FREEWAT project are: - to coordinate previous EU and national funded research to integrate existing software modules for water management in a single environment into the GIS based FREEWAT; - to support the FREEWAT application in an innovative participatory approach gathering technical staff and relevant stakeholders (in primis policy and decision makers) in designing scenarios for the proper application of water policies. FREEWAT will initiate a process aimed at filling the gap between EU and US on widespread-standardised ICT tools and models for management of water quantity and quality and will set a well recognisable and flagship initiative. The open source characteristics of the platform allow to consider this an initiative "ad includendum" (looking for inclusion of other entities), as further research institutions, private developers etc. may contribute to the platform development. Through creating a common environment among water research/professionals, policy makers and implementers, FREEWAT main impact will be on enhancing science- and participatory approach and evidence-based decision making in water resource management, hence producing relevant and appropriate outcomes for policy implementation. The Consortium is constituted by partners from various water sectors from 11 EU countries, plus Switzerland, Turkey and Ukraine. Synergies with the UNESCO HOPE initiative on free and open source software in water management greatly boost the value of the project. Large stakeholders involvement guarantees results dissemination and exploitation.

Keywords: implementation of eu water related policies,participatory approach,open source and public domain software,gis integrated water management modelling
Illuminating the 'Grey Zone': Addressing Complex Complicity in Human Rights Violations (GREYZONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1349481.0
EU funding (EUR): 1349481.0
Participants: 1
Project status: CLOSED

The grey zone of bystanders, collaborators and beneficiaries of violence escapes the scope of main Transitional Justice (TJ) institutions and poses tough questions for scholars and architects of post-conflict societies. This interdisciplinary project shifts the focus of academic and political debates by pursuing three objectives: conceptually, it departs from the dominant victim-perpetrator paradigm and theorises the many faces in the grey zone by analysing the interplay between structure and agency; normatively, it argues that no account of TJ is complete without engaging the grey zone; empirically, it tests if, in tackling the grey zone, cinematographic and literary representations can supplement typical TJ mechanisms (trials, truth commissions, lustration). Four cases are analysed: authoritarianism plus military occupation (Vichy France), apartheid (South Africa), totalitarianism (Romania 1945–1989) and military dictatorship (Argentina 1976–1983). The cases provide a variety of contexts of complicity and feature the most frequently used TJ mechanisms. They serve to a) examine the relationship between the official story emerging from state-orchestrated TJ mechanisms and artistic narratives of complicity; b) contextually distinguish disclosive from obscuring artistic representations of the grey zone; c) explore the contribution of these representations to TJ efforts by studying their effect on public debates about—and institutional responses to—the past. Working at the frontiers between political science, philosophy, history, law, literature and cinema, this pioneering project has critical and institutional impact. Critically, it discloses the limits of current TJ theory and practice by emphasising the negative political effects of ignoring general complicity in violence. Institutionally, it seeks to enrich the toolkit of scholars and practitioners by pointing to the potential use of cinema and literature in civic education aimed at deterrence and reconciliation.

Keywords: transitional justice,complicity in political injustice,political role of art
The development of Personalised Host Response Diagnostic kit (PHRD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Drug resistance is a major reason for failure in cancer chemotherapy and/or modern targeted drugs. While tumours usually initially respond to therapy, resistance occurs within several cycles of treatments, or later on when patients are off therapy. Until recently, acquired and intrinsic resistance mechanisms for therapy were thought to be solely tumour driven. They are usually measured after tumours relapse or after several lines of treatments. However, in our ERC starting grant (HostResponse No. 260633), we found a novel way to predict resistance to therapy, already after 24 hours after the first drug administration. This discovery resulted in a new stream of research by means of published papers and the formation of special interest groups in cancer research and pharmaceutical disciplines that tackle this paradigm shift in cancer therapy. During our discussions with the cancer community, a clear need has emerged for a Specific Host-Driven Resistant Mechanisms (SHDRM®) diagnostic platform which will serve two (closely connected) markets:(1) the research community – enabling researchers to further examine this new paradigm; and (2) Clinicians- enabling oncologists to identify each patient specific host driven resistance mechanism and repurpose off-the-shelf drugs to counteract the specific factor driving the resistance. PHRD goal is to technically validate and develop a diagnostic platform Prototype for both markets including a clinical study design report which will enable to secure our partners including drug manufacturers, diagnostic providers, and the research community to commit to jointly push the new PHRD standard.

Keywords: personalised therapy,diagnostic biomarkers,cancer therapy,drug resistance
Soft-matter collective phenomena in Rydberg gases (SoftRyd)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Understanding the behaviour of quantum many-body systems out of equilibrium remains one of the central challenges in condensed-matter physics. The complex collective phenomena that are observed in such systems present many similarities to those observed in supercooled liquids and glasses, and their study would therefore greatly benefit from the insights and approaches developed in out-of-equilibrium soft-matter physics. However, the relevant research communities remain for the most part disconnected. We propose to bridge this gap by addressing the collective non-equilibrium dynamics of Rydberg gases (i.e., gases of atoms excited to high-lying energy levels) using ideas and approaches from soft-matter physics. One of the main objectives of the proposal is the study of the quantum regime, which remains as yet unexplored. The other main objective is the study of gases of multilevel Rydberg atoms, i.e. going beyond the two-level paradigm according to which atoms can only be in their ground state or in one excited state. Both objectives aim to break new ground by significantly expanding and generalising previous work on the dynamics of Rydberg gases, and each of them leads to ramifications that lend themselves quite naturally to a study based on the ideas and methods developed in soft-matter physics. The proposal combines the research experience and skills the Experienced Researcher acquired in the study of disordered, glassy and complex systems (which will provide the Host Institution with much needed skills and knowledge) with the internationally recognised expertise of the Supervisor in quantum many-body systems in general, and Rydberg gases in particular (which will help the Researcher to acquire new knowledge and skills through training and research activities). This rather unusual combination of backgrounds is uniquely suited for carrying out this challenging research programme, and ultimately leading the Researcher to pursue an independent scientific career.

Keywords: quantum many body systems,out of equilibrium dynamics,rydberg gases,soft condensed matter,glassy physics
GRECA: Revolution in corporate transactions (GRECA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GRECA will be the first Network As A Service (NAAS) democratizing M&A management. GRECA stands for GRowth, Equity and Commercial Alliances. It is a disruptive platform solution to make low-to-mid market (between €1M and €100M) corporate transactions, such as sales of companies or its assets, mergers, consolidations or other capital reorganizations more transparent and efficient. Our aim is to integrate all stakeholders of the M&A processes in an Artificial Intelligent platform designed to give advice based on proprietary algorithms that will learn each investor's decision-making process, matching them with suitable companies. With the current Minimum Viable Product in production environment being tested by early adopters of our technology , we predict to generate by 2023 €8,85M in revenues and €4,24M in profit by having enabled 314 transactions, 145 advisory services and generated 6280 valuation reports. GRECA is a proprietary technology owned by m27 Finance, a company specialized in structured financing as well as internationalization with a regional focus on CEE (Central and Eastern Europe, including Austria, Germany and Switzerland). We count with more than 2,500+ successfully completed projects.

Keywords: marketplace,corporate transactions,dealflow,company valuation and assessment