Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Achievement of Excellence in Electron Processes for Future Technologies (ELEvaTE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Slovakia,United Kingdom
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2019-03-31
Duration (months): 39.0
Total project cost (EUR): 989625.0
EU funding (EUR): 988125.0
Participants: 3
Project status: CLOSED

This H2020 Twinning project ‘Achievement of Excellence in Electron Processes for Future Technologies’ (ELEvaTE) is aimed at advancing the excellence of the Electron and Plasma Physics Laboratory (EPPL) in the Faculty of Mathematics Physics and Informatics, Comenius University in Bratislava such that it becomes a centre of international excellence and an exemplar for other Slovakian HEI while furthering the Strategy for Smart Specialization of the Slovak Republic. EPPL has an established scientific reputation and has exploited its expertise in the development of novel future technologies. The EPPL is integrated in some international programmes and has hosted conferences but lacks experience in leading international projects, industry cooperation and disseminating results. The goal of the ELEvaTE is to provide the EPPL opportunity to learn from partners to achieve ambition of creating a centre of excellence. ELEvaTE will twin EPPL with the Molecular Physics Group at the Open University (OU) in United Kingdom and Nano-Bio-Group at the Institute for Ion Physics and Applied Physics at the University of Innsbruck (UIBK). The OU is exceptional in results dissemination and the UIBK combines research with enterprise (e.g. ‘spin out’ company Ionicon, world's leading producer of PTRMS), both are exemplars of ‘widening participation and gender sensitive research’ and are strong in preparing IPR. ELEvaTE will be implemented through work packages with clear and measurable deliverables. The UIBK will lead the academic-industry cooperation and technology transfer while the OU will focus on means of results dissemination. The EPPL will adopt new codes of practice on technology transfer, academic-industry partnerships and revise its management structures to implement and sustain excellent science. The partnership will be exploited for submitting joint research project proposals especially within H2020. The EPPL will transfer its knowledge and scientific excellence to other HEIs.

Keywords: electron molecule collisions,cross section,scientific excellence improvement
One Valve For Life: The First Durable Non-Thrombotic Heart Valve Prosthesis (TRIFLO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-04-01
End date: 2023-07-31
Duration (months): 40.0
Total project cost (EUR): 3562550.0
EU funding (EUR): 2493785.0
Participants: 1
Project status: SIGNED

Novostia is a medical device company with the mission to provide young patients suffering from heart disease with a solution for life: the TRIFLO valve. Valvular heart disease affects more than 100 million people worldwide. Every year >500.000 patients undergo a heart valve replacement. For patients younger than 65 years, currently available valves have serious constraints: either blood clot formation requiring lifelong dangerous anticoagulation therapy (with mechanical valves), or deterioration leading to replacement on average every 10 years (with animal tissue-based valves). Therefore, cardiovascular surgeons are urgently seeking a durable and non-thrombogenic valve prosthesis. Thanks to a unique patented tri-leaflet design, which allows for optimal blood flow patterns, and the use of a novel high-performance biocompatible material, the TRIFLO valve does not induce blood clot formation, while at the same time is durable for life. The TRIFLO valve could thereby substantially improve the quality of life of millions of patients worldwide, whilst reducing overall healthcare costs. Novostia’s technology results from a unique collaboration between a cardiovascular surgeon and an aerospace engineer. The team includes seasoned experts in medical devices, quality and regulatory affairs, cardiovascular surgery and engineering. The EIC Accelerator grant, combined with €6.5M raised in 2018 from private investors, will enable the company to finalize activities necessary to complete first clinical trials, a major step towards CE Marking and commercialization. Novostia will then target a licensing agreement with a global medical device company to ensure an effective marketing and clinical implementation of the device. Alternatively, sales via regional distributors will be considered.

Keywords: heart valve disease,aortic valve prosthesis,non thrombogenic,anticoagulant free,durable for life
Fundamental Breakthrough in Detection of Atmospheric Free Radicals (RADICAL)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Ireland,Greece,Bulgaria,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 3235368.75
EU funding (EUR): 3220108.75
Participants: 6
Project status: SIGNED

Atmospheric radicals, particularly hydroxyl (•OH) and nitrate radicals (•NO3), are the drivers of chemical processes that determine atmospheric composition and thus influence local and global air quality and climate. Current techniques for measuring radicals are based on spectroscopic and mass spectrometric methods, which are technically complex, cumbersome and expensive. As a result, the measurement of atmospheric radicals is far-from-routine and only a few research groups worldwide can perform them in a very limited number of geographic locations. There is therefore a clear need to develop new radical detection techniques which are much easier to implement and deploy than existing methods. The central aim of RADICAL is to develop and deliver the science and technology to electrically detect and quantify, for the first time, short lived •OH and •NO3 radicals in the atmosphere via new, low-cost and easily accessible Si junctionless nanowire transistor (Si JNT) devices. These devices will lead to improved monitoring and control of air quality and better predictions of climate change. Three breakthrough science and technology targets have been identified: 1) fabrication and functionalisation of arrays of Si JNTs for the selective and highly sensitive electrical detection of •OH and •NO3 radicals, 2) electrical detection of atmospheric •OH and •NO3 radicals under a range of laboratory conditions and 3) evaluation and validation of the radical detectors under realistic conditions in an atmospheric simulation chamber and via deployment in the ambient atmosphere. Expertise in electronics, computer modelling, materials and surface science, nanofabrication, radical chemistry and atmospheric science is integrated on a pan-European level to achieve the overall aim of the project. This knowledge developed in RADICAL has the potential to bring about a dramatic breakthrough in air quality and climate monitoring, leading to health benefits for European citizens.

Keywords: atmospheric free radicals,electrical detection,nanowire transistors,surface functionalisation,radical detection,atmospheric simulation chamber,oh radical measurement,computer modelling
Slow-Fast Systems in Cellular Biology (SFSysCellBio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-08-30
End date: 2019-08-29
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Mathematical modelling has emerged as an important tool to handle the structural complexity of cellular processes and to gain better understanding of their functioning and dynamics. We propose to develop methods for the mathematical analysis of ODE models arising in cell biology. We focus on models of great biomedical importance, i.e. cell division cycle, NF-kB signalling pathway, and the p53 system. Pertinent mathematical questions of biological interest are: existence and stability of equilibria, periodic oscillations, switching phenomena, and bifurcations. Often the analysis of such models relies heavily on computational approaches but qualitative analysis is also very important. Detailed models of individual pathways or the cell division cycle are too large for theoretical analysis. However, there is evidence from simulations that often only a small or moderate number of components of a large systems play essential roles, while other parts have almost negligible roles. This allows the systematic use of perturbation methods. In particular slow-fast dynamical systems, i.e. systems with solutions varying on very different timescales are abundant in biology in general and in cellular biology in particular. The approach in this project relies strongly on novel dynamical systems methods for systems with multiple time scale dynamics, known as geometric singular perturbation theory (GSPT). Interestingly, the models under investigation do not have the standard form covered by the existing theory. Due to these difficulties GSPT has not been applied systematically in this area. An extended version of GSPT - using hierarchies of local approximations - will be developed for the specific models. The project will lead to better understanding of cell-cyle and signaling pathway models. These issues and the methods to resolve them are of great importance also for other models in cellular biology and also for slow-fast dynamical systems in general.

Keywords: geometric singular perturbation theory,model reduction,oscillations,cell cycle,signaling pathway
Novel Strategies to Fight Child Sexual Exploitation and Human Trafficking Crimes and Protect their Victims (HEROES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Spain,Uruguay,Austria,Spain,Ireland,Switzerland,Greece,Lithuania,Colombia,Belgium,Bulgaria,Greece,Latvia,France,Portugal,Bangladesh,Brazil,United Kingdom,Peru,United Kingdom
Call: Human factors, and social, societal, and organisational aspects to solve issues in fighting against crime and terrorism (H2020-SU-SEC-2020, 2020)
Start date: 2021-12-01
End date: 2024-11-30
Duration (months): 36.0
Total project cost (EUR): 5427000.0
EU funding (EUR): 4999500.0
Participants: 29
Project status: SIGNED

Trafficking of human beings (THB) and child sexual abuse and exploitation (CSA/CSE) are two big problems in our society. Inadvertently, new information and communication technologies (ICTs) have provided a space for these problems to develop and take new forms, made worse by the lockdown caused by the COVID-19 pandemic. At the same time, technical and legal tools available to stakeholders that prevent, investigate, and assist victims – such as law enforcement agencies (LEAs), prosecutors, judges, and civil society organisations (CSOs) – fail to keep up with the pace at which criminals use new technologies to continue their abhorrent acts. Furthermore, assistance to victims of THB and CSA/CSE is often limited by the lack of coordination among these stakeholders. In this sense, there is a clear and vital need for joint work methodologies and the development of new strategies for approaching and assisting victims. In addition, due to the cross-border nature of these crimes, harmonisation of legal frameworks from each of the affected countries is necessary for creating bridges of communication and coordination among all those stakeholders to help victims and reduce the occurrence of these horrendous crimes. To address these challenges, the HEROES project comes up with an ambitious, interdisciplinary, international, and victim-centred approach. The HEROES project is structured as a comprehensive solution that encompasses three main components: Prevention, Investigation and Victim Assistance. Through these components, our solution aims to establish a coordinated contribution with LEAs by developing an appropriate, victim-centred approach that is capable of addressing specific needs and providing protection. The HEROES project’s main objective is to use technology to improve the way in which help and support can be provided to victims of THB and CSA/CSE.

Keywords: child sexual abuse,digital forensic,trafficking in human beings
SinuShunt – New disruptive medical device for treatment of hydrocephalus (SINUSHUNT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2021-09-30
Duration (months): 32.0
Total project cost (EUR): 998375.0
EU funding (EUR): 698862.5
Participants: 1
Project status: CLOSED

Hydrocephalus is a devastating neurological condition caused by accumulation of cerebrospinal fluid (CSF) on brain, and If left untreated, it can be fatal. The only treatment option is surgical, either implantation of a shunting device placed centrally in the brain, or, in some cases, by use of an endoscope going through the brain substance to its central part. The main problem in the industry is that conventional treatment systems (shunts) are based on a technology from 1950s and they are failing on average in 4-8 years, due to blockage or over-drainage. This results in 100 000 re-operations annually and brings a lot of complications (incl. increased infections) to the patient. Furthermore, this inefficiency represents an additional cost of €1.5B for the health care systems annually. To offer a solution to these problems, CSF-Dynamics is developing a new disruptive implantable medical device for treatment of hydrocephalus. The main innovation is draining the cerebrospinal fluid into sinus vein that is a natural resorption place of CSF, instead of conventional chest or abdomen. The hunt system uses novel stent technology as an outlet into the sinus vein, to avoid obstruction. SinuShunt competitive advantages are: 1) significantly increased life-time of the shunt, therefore reducing amount of re-operations; 2) Better quality of life for the patient due to the close to normal drainage of the brain-fluid, avoiding over-drainage and complications thereof. Hydrocephalus market is currently valued at €1.2B and is expected to reach a value of €1.6B by 2023. The market is steadily growing at CAGR of 4.4% during this time period. The market growth is propelled by growth in aging of population, increasing awareness of the condition and constantly improving diagnostic tools. Our end-users are hydrocephalus patients and users neurosurgeons. By 2026 we expect to sell our solution internationally, employ additional 112 people, and achieve a ROI of 40.6.

Keywords: hydrocephalus,water on the brain,implantation,medical device,surgery
Comprehensive identification of host factors involved in the early steps of HIV infection. (hRBP-virion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-03
End date: 2019-05-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

35 million people are currently infected with Human immunodeficiency virus (HIV), causative agent of AIDS. While cocktails of anti-retrovirals can reduce viral loading to undetectable levels, drug resistance can emerge due to the high-mutation rate of the virus. Moreover, no cure is yet achieved. Therefore, it is crucial to explore complementary therapeutic strategies, a challenge that H2020 prioritizes in health. The strict dependency of HIV on host RNA-binding proteins (RBPs) represents a potential step for intervention through host-based therapies, which can be more refractory to the evolution of resistance. In some sporadic cases, host RBPs have been shown to be incorporated into virions and impact downstream early steps of infection. However, no global and systematic studies aimed to determine the scope and biological significance of host RBPs selectively packed with the HIV RNA within the virions have been reported so far. The main goal of this action, referred to as hRBP-virion, is to address this important biological question by developing an unprecedented multidisciplinary approach that combines molecular biology and virology methods with next generation proteomics and data analysis. Hence, this pioneer approach will open new avenues of research in the field of viruses that have major health and socioeconomic impact and will enhance world-class basic and applied European innovation. The hRBP-virion project requires an exclusive mix of competences. I will bring research experience in RNA and molecular virology. My supervisor will train me in cutting-edge, system-wide proteomic methods. The host institution will provide state-of-the-art facilities and pooled expertise in a broad range of disciplines. Together these will create an excellent and unique cross-disciplinary atmosphere that will ensure the successful outcome of hRBP-virion and the appropriate transfer of knowledge among the participants.

Keywords: rna binding proteins,protein rna interaction,interactome capture,aids
Morphogenesis of photo-mechanized molecular materials (Morpheus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1425657.44
Participants: 2
Project status: SIGNED

The sophistication reached by organic chemistry has enabled the design and synthesis of a wide range of dynamic molecules that display controlled shape changes with an ever-increasing refinement. However, amplifying these molecular-scale dynamics to support shape-transformation in a broad range of macroscopic functions remains a key challenge. To address this challenge, I draw inspiration from living materials where molecular machines maintain out of equilibrium states by ingenious coupling with their anisotropic supramolecular environment, and ultimately promote the appearance of emergent properties on higher levels of organization. The aim of Morpheus is to develop shape-shifting materials and shape-generating photochemical systems by amplifying the motion of molecular machines over increasing length scales, towards the emergence of cohesive shape transformation in artificial tissue-like materials. We will (i) develop motorized materials by coupling light-driven molecular motors to liquid crystals and pre-program photoreaction-diffusion processes to achieve continuous motion; (ii) combine microfluidics with the anisotropic response of liquid crystal elastomers to create a library of shape-shifting bubbles and shells that undergo pre-programmed shape modification under irradiation with light; (iii) promote adhesion between units of mechanized matter, while preserving their original shape-shifting and shape-generating properties; and (iv) assemble tissue-like morphing materials from large cohesive networks of shape-shifting micro-spheres. This project will lay the scientific foundation for a new and multidisciplinary approach towards shape-generating molecular materials. It will yield unprecedented examples of emergent dynamics, provide simple models to untangle the underpinnings of mechanical transduction in nature, and contribute to developing new paradigms for the design of active matter.

Keywords: molecular motors and switches,complex molecular systems,biomimetic materials
Reference standards for a specific, reliable and early detection of the marine toxins that causes ciguatera disease (CIGUALERT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The worldwide most common type of marine foodborne intoxications is Ciguatera Fish Poisoning (CFP) caused by the consumption of fish contaminated with ciguatoxins (CTXs).It is estimated that affects up to 500,000 persons poisoned, annually. Only in USA it is estimated economic losses of up to 82 million $/year from HAB, related mainly to commercial fisheries impact (37%) and public health costs (45%). CIGUALERT project will be focused on the commercialization of analytical standards able to substitute current and unspecific unique mouse bioassays method for the detection of marine CTXs in fishery products for a specific, reliable and rapid chromatographic analytic method, allowing the quantification of CTXs content. Then the benefits of CIGUALERT are not only economic, but also social and environmental, including the following ones: - Reduce the population affected annually by CFP. - Reduce animal testing - Provide a reliable method 5 times faster - Accomplish the legislation with a reliable method. Increase CTX’s controls in European imported fish to guarantee the total absence of CTXs and increase controls at international level. Total global market for CTX detection in the Fishery Sector has been estimated in 1,2 billion €. The commercial objectives of CIGUALERT have a clear focus in Reference laboratories, private laboratories, food industry, research centers and universities. Main identified segment market is Public Health Inspection Laboratories for the introduction of the new product. Major goal in Phase 1 is to develop a business and a practical viability plan, including the assessment of the cost-effectiveness and exploitation potential. Then, the next step for Phase 2 will be to increase the characteristics of the product to adapt it to the commercial needs.

Keywords: ciguatera toxin,ciguatera fish poisining cfp,reference standard,analytical detection method