Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Symmetry Tests in Experiments with Portable Antiprotons (STEP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 1792151.0
EU funding (EUR): 1792151.0
Participants: 1
Project status: SIGNED

Our present understanding of particles and their fundamental interactions leaves us with extremely well tested theories in laboratory experiments, however cosmological observations indicate that our models are incomplete. Dark matter and dark energy are clearly not contained in our theories, and the baryon asymmetry in the universe cannot be reproduced from the Standard Model with its current parameters. Antiprotons offer the unique opportunity to make high-precision measurements at low energies in the antimatter sector and provide important tests of the fundamental interactions to search for a manifestation of new physics complementary to matter-based experiments. Here, I propose to extend the methods in low-energy antiproton precision measurements by developing a transportable antiproton reservoir. Relocating measurements from CERN’s antiproton decelerator into precision laboratories eliminates limitations from magnetic field noise in the antiproton decelerator hall and improves the precision by at least a factor of 30. I will also implement a novel method for ultra-precise cyclotron frequency measurements based on low-energy thermal-state selection for single antiprotons and quantum non-demolition measurements of the cyclotron energy. This leads to measurements at 300-fold reduced temperature compared to the state-of-art methods. Using these two methods, I will improve the most precise test of CPT invariance in the baryon sector by at least a factor of 70 and demonstrate charge-to-mass ratio comparisons with unprecedented precision. I will also set first limits on the interaction of light dark matter and antiprotons by searching for topological defects by simultaneous measurements of the antiproton cyclotron frequency in two separate experiments. The developments provide also methods to test whether the weak equivalence principle holds for charged antimatter by comparing the gravitational redshift of protons and antiprotons at different altitudes.

Keywords: antiproton,penning trap,precision measurements,cpt symmetry,fundamental interactions
A unique and universal antibacterial coating for prevention of hospital acquired infections associated with the use of medical devices (CYTAMED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of the current project is to develop a strong business plan that includes market analysis and clinical validation strategies to commercialise CytaCoat. 1 in 18 patients in a European hospital acquire Healthcare-Associated Infections (HAIs) mainly as a result of colonisation and formation of microbial biofilms on the surface of medical devices that are in lengthy contact with patients. At present, antimicrobial substances and silver agent coating are used as preventative measures, while antibiotics are used for treatment following HAIs. These strategies either contribute to antimicrobial resistance or potentially dangerous due to the release of harmful silver substances in the body. To overcome this, CytaCoat has developed a unique and stable antimicrobial coating that uses non-toxic, biocompatible organic compounds that strongly bind to the surface of the device through covalent bonding. This impedes microbial colonization and reduces the likelihood of antimicrobial resistance to the coating. These features distinguish CytaCoat from all competing products on the market. The first application for the coating are neonatal nasal prongs for non-invasive ventilation support, however the coating can be applied to all invasive and non-invasive medical devices. The research performed to date strongly supports CytaCoat’s ability to hinder microbial colonisation. The coating is easily applied to all devices using a defined protocol developed by the company. This project will help facilitate the road towards commercialisation.

Keywords: antibacterial coating,hospital acquired infections,nasal prongs,medical devices
High-resolution, all-digital microscope that applies computational methods to bring revolutionary benefits of digital microscopy to small and medium sized laboratories (SCOPIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scopio Labs aims to expand the use of Whole Slide Imaging (WSI) for its application in digital pathology and is developing a digital microscopy platform capable of scanning high resolution images with low hardware costs. Despite digital microscopy exists for decades, its use has been limited by the high prices of the technology. Our solution provides a low cost-high quality technology which will allow the implementation of WSI facilities in small hospitals and diagnostic centres. By using cutting edge principles of computational photography, we are able to enhance resolution and magnification (up to 100X) of images taken by affordable optics and mechanics through a disruptive computation method. Biopsies are frequently used to determine different diseases as psoriasis, diabetes, hepatic diseases, infections or cancer. Every year, more than 3 million new cancers are diagnosed and cancer is causing around 1.7 million deaths worldwide. Its early diagnosis has been pointed out as a factor for increasing patient survival. Our technology upgrades the diagnosis process with substantial time savings and connects and assists pathologists and experts worldwide with its analysis software. We estimate the total addressable market for WSI, including the sale of hardware, software and services enabled by the digitization of glass slides, to grow from $1.3B/year to $11B/year in the next decade. We forecast that during the next five years after commercialization, we will have sold about 3,150 digital microscopes and hired 38 new employees. We will earn almost €58M profit with a ROI of 6.47. Payback will be reached already in 2021.

Keywords: whole slide imaging,digital pathology,computational photography,digital microscopy platform
Big dAta aNalYtics for radio Access Networks (BANYAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-12-01
End date: 2024-04-30
Duration (months): 53.0
Total project cost (EUR): 1360393.92
EU funding (EUR): 1360393.92
Participants: 3
Project status: SIGNED

As mobile services consumed by people and machines become increasingly diversified and heterogeneous, 4G/5G networks are asked to meet a growing variety of Quality of Service (QoS) requirements. Network slicing, enabled by Network Function Virtualization (NFV), is a promising paradigm to increase the agility and elasticity of the mobile network via logical slices that can be formed and composed dynamically, so as to adapt to the fluctuations in the demands for different mobile services. A key enabler for network slicing is accurate data-driven models and the prediction of the spatio-temporal dynamics of the mobile service traffic, which allow discovering knowledge relevant to the orchestration of slices and anticipating the need for their reconfiguration. The need for effective data-driven slice management is especially critical in proximity of indoor Radio Access Network (RAN), which must accommodate most of the volume and variations in the demand associated to each mobile service and whose performance is crucial to user QoS. The BANYAN project is designed to address major open issues towards the realisation of data-driven 5G RAN, as follows: - Modelling and forecasting macroscopic high-dimensional mobile traffic patterns observed at RAN for individual services, at multiple scales in time and space; - Geo-locating and characterising in-building mobile traffic patterns observed at RAN; - Designing data-driven strategies for the allocation of 5G RAN resources; - Designing data-driven policies for the orchestration of 5G RAN resources to suit service requirements and dynamics via network slices; - Coordinating outdoor and indoor heterogeneous networks to meet user QoS requirements. To address the research objectives above, BANYAN pursues a tight academic-industrial cooperation, which will allow developing key tools for data-driven 5G RAN, as well as properly training early-stage researchers who are urgently needed by industry, academia, etc.

Keywords: big data analysis,radio access network
Remote Control of Electrical Transmission Tower (ReCETT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: France
Call: Critical infrastructure protection topic 7: SME instrument topic: Protection of Urban soft targets and critical infrastructures (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

It’s urgently needed to assess automatically and in real time the stability of the High Voltage Electric Transmission and Distribution (T&D) Grid in Europe, as 5% (≈ 9000 in France and Italy) of the towers face small displacements and deformations. The present field inspection and/or drones/helicopters surveys in order to check “visually” maximum twice a year the stabilities of each European high voltage transmission tower is expensive and far beyond the needs. These tilted towers finally induce local/regional power shutdown, source of discomfort, waste of time and money for EU citizens. We propose herein a new small, automatic and autonomous, reliable and high precision, low energy consumption and low cost remote monitoring device (Remote Control of the Electrical Transmission Tower or ReCETT) to settle on transmission towers that measure various parameters (tilting, temperature, etc.) as well as its surroundings using “slave” monitoring devices. Then data are transmitted in real time to end-users through the cell phone/radio network on various types of devices (PC, tablet, smartphone). Transmitted data are simply processed by our dedicated software that we intend also to develop and optimize through phase 2 funding. So ReCETT, by monitoring unstable towers and their surroundings and real time automatic transmission data, optimize efficiently the maintenance, the stability and the continuity of EU power lines, prevent power shutdown, and even more lead the possibility to create new power lines in all European areas (even in unstable areas!). So ReCETT optimize both the EU power grid and the staff of any European electric companies which consequently will reduce the electric costs to EU citizens. ReCETT is also used to monitor other infrastructures, such as buildings, pipes, tubes, wind turbines, dams... The real time transmitted data to deciders and end-users will finally lead to a real EU risk mitigation.

Keywords: critical infrastructures,transmission tower,remote control,autonomous platform multisensor power,grid,low cost sensor,transmission and distribution network
Helically-Locked π-Conjugated Oligomers and Polymers with Tunable Twist (PolyHelix)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1460375.0
EU funding (EUR): 1460375.0
Participants: 1
Project status: SIGNED

The performance of organic electronic materials is strongly dependent on their conformation. Twisting these materials out of planarity induces chirality and thus results in new electronic, magnetic, and optical properties with increasing numbers of applications as non-liner optical devices, spin filters, and magneto-optical devices. However, the effect of twisting is poorly understood, as it is difficult to isolate from other factors. Moreover, twisting often comes at the expense of π-conjugation, resulting in inferior device performance. Using a novel approach, I propose to address this challenge by introducing a new family of helically-locked organic electronic materials, oligomers and polymers, in which the twist of the π-conjugated backbone can be finely tuned. This will allow us to monitor and understand the effects of twisting on the electronic, optical, and magnetic properties of organic electronic materials. Unlike most chiral conjugated materials, the proposed approach allows the formation of polymers with a tunable twist, helical backbone chirality and strong π-conjugation, a combination often difficult to obtain. Following our preliminary findings, which successfully demonstrated the helical locking of small acene units to a specific twist angle, my team will focus on five ambitious projects: 1) Synthesis of extendable twistacene units. 2) Synthesis of helically-chiral oligomers polymers with tuneable twist. 3) Study of the effect of twisting on the charge and energy transfer processes. 4) Synthesis of open shell twisted acenes. 5) Understanding the effect of twisting on the magneto-optical properties and chiral-induced spin selectivity. The successful introduction of the abovementioned twisted backbones will allow us to understand the influence of molecular structure on fundamental properties of organic electronic materials, and the acquired knowledge will lead to design new materials for efficient optoelectronic, magneto-optic and spintronic devices.

Keywords: organic electronic materials,chiral organic semiconductors,acenes,polyaromatic hydrocarbons,conjugated polymers,materials chemistry,cyclophanes,twistacenes,curved aromatic molecules
PROSME - Improving RO3 SMEs management of innovation (PROSME-INN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Romania,Romania,Romania,Romania
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 109775.0
EU funding (EUR): 109775.0
Participants: 12
Project status: CLOSED

PROSME services in RO3 region regarding SME Instrument support will ensure the delivery of “Key Account Management” (KAM) support services, enhance innovation management capacity and processes of SMEs, develop and test PROSME partners capacities for consultancy services.

Keywords: innovation management,key account management,enterprise europe network
Total Synthesis of Biologically Important Pyrrolidinone Natural Products and Analogues Thereof. (SYNOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The importance of natural products and derivatives as sources of new drugs is undeniable. Newman has stated: "It is probably true that if one had to name the natural product that has saved the most lives.....penicillin G would be the molecule of choice" (D. J. Newman, G. M. Cragg, in Natural Product Chemistry for Drug Discovery, Chapter 1, RSC Biolmolecular Sciences No. 18, 2009). In this proposal we will develop methodology for the synthesis of two types of closely related natural products which have wide-ranging biological activities including: anti-bacterial, anti-viral, anti-tumour and herbicidal activity; but whose biological activities have not been fully evaluated. We will use our recently developed oxidative radical cyclisation methodology to synthesise the cores of these biologically relevant natural products and develop new methodology for the direct functionalisation of certain aromatic heterocycles as part of the synthesis of the unsaturated portions of the natural products. The biological activities, particularly with respect to anti-bacterial and anti-tumour properties of all of the key synthetic intermediates (simplified analogues) and synthetic natural products themselves will be assessed. The project is divided into four work packages involving: i) development of direct functionalisation certain aromatic heterocycles; ii) synthesis of the the one type of natural product; iii) oxidative radical synthesis of natural product cores; iv) total synthesis of the second type of natural product.
House Architecture and Heritage in modern Crete (HArchitHeC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 164653.2
EU funding (EUR): 164653.2
Participants: 1
Project status: CLOSED

Cretan minor built heritage dating back to the Venetian and Ottoman periods has until now received scarce attention by scholars and local authorities. The two-year HArchitHeC project (House Architecture and Heritage in modern Crete) wants to focuses on rural and urban houses of Crete in order to reach three main goals: to perceive the built environment in its materiality and its historical evolution; to study how the evolution and interaction of Venetian and Ottoman cultural models built up a hybrid architecture in a colonial dimension; and to identify possible strategies for heritage protection by bringing research to the public realm. To do so, an interdisciplinary innovative approach will be used: a historical study of written sources and an architectural comparative study, by means of an inventory and a comparative study of Venetian and Turkish house prototypes. Such a pilot project aspires to a wider comparative study between Crete and the nearby regions, starting with other Mediterranean islands (Rhodes and Cyprus at first). HArchitHeC represents the first occasion to put into effect a mutual commitment between the two institutions that is the IMS (Greece) as the Host and Aix-Marseille University (France) as the Partner. They will provide an ideal human and scientific environment for the fellow, supporting her research and career development. The fellow’s previous achievements in terms of fieldwork and research, as well as her knowledge of Cretan territory and academic staff will allow her increasing methodologies and results. She will reinforce her competences and acquire new skills: her ultimate goal is to be fully integrated in the fields of cultural history and architectural heritage, acting on European society and science. HArchitHeC shows its relevance to the work programme, since it foresees a complete plan of training-through-research, as well as specific outreach and communication activities to reach a wide audience beyond academics.

Keywords: house architecture,heritage,built environment,modern crete,venetian,ottoman,survey,materiality,written sources,morphological analysis,inventory,landscape archaeology
In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells (NeuroInCellNMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel,Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2022-10-31
Duration (months): 84.0
Total project cost (EUR): 1996500.0
EU funding (EUR): 1143821.37
Participants: 2
Project status: CLOSED

Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder. The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures directly in neuronal cells. To achieve this goal, we will employ different sets of cultured neurons and investigate intracellular alpha-synuclein aggregation under defined conditions of mitochondrial dysfunction and cellular oxidative stress, two of the most common denominators of the disease. Importantly, we will also establish a human stem cell model for studying alpha-synuclein aggregation with high-resolution in-cell NMR and EPR methods, by using induced pluripotent stem cell (iPSC) derived dopaminergic neurons from Parkinson’s disease patients and control individuals. Results from this study will provide novel insights into the native mechanisms of intracellular aggregate formation and ultimately enable novel pharmacological approaches for therapeutic intervention.

Keywords: cellular structural biology