Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Know thy neighbor (KNOWN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Understanding the social networks of plants is essential for predicting their coexistence. For decades, intraspecific interactions were assumed to be purely competitive in nature. However, recent experimental evidence has demonstrated the existence of positive interactions for various wild plant species, wherein a genotype can recognize a conspecific, and cooperate to reduce competitive growth when growing with either their kin, or even an unrelated intra/con specific. My PhD research took this a step further by giving the first-ever evidence for the existence of both these types of positive interactions within the same plant species, varying between natural populations. To alter their competitive response, plants must have mechanisms to reliably distinguish the identity of their neighbors. The root systems are known to be critical for sensing and integrating signals that allow plants to perform elaborate behaviors similar to those of intelligent animals. Yet, the underlying mechanisms remain largely unknown. This project aims to understand the direct or indirect role of root-secreted compounds in mediating neighbor perception and recognition in conspecific interactions. To do this, we will combine interdisciplinary approach at the interface of evolutionary ecology, chemistry, quantitative genetics, and microbiology Understanding how plants recognize each other is a crucial step in determining how competitive traits evolve in intraspecific plant-plant interacting systems, which has implications in both natural and agroecological contexts. Comprehending intraspecific recognition mechanisms can ultimately help illuminate the dynamics of natural plant populations and aid in predicting their resilience in the face of current and future global changes. More importantly, understanding this link between recognition and belowground plastic responses can be exploited to design efficient crop variety mixtures with high yield potential owing to cooperative interactions.

Keywords: intraspecific interactions,recognition,cues,root exudates,trait plasticity,eco evolutionary genomics,gwa mapping,chemistry,microbiology,local adaptation,rhizobiome,interdisciplinary
Deciphering the Transcriptional Logic of TFEB activation in cell identity and cancer (EpiTFeb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-04-28
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The discovery that lysosomal biogenesis is subjected to a global transcriptional control and that the transcription factor TFEB is the primary driving force for the coordinated expression of lysosomal genes has empowered intense investigations on the molecular mechanisms regulating cellular homeostasis. Modulation of TFEB expression and activity is therefore crucial in cellular adaptation to a wide variety of internal stresses and environmental fluctuations. While many studies have been focused on TFEB post-translational modifications and on how they can affect its subcellular localization and function, little attention has been given to how TFEB expression is regulated at the transcriptional level across different cell types and nutritional states hampering the capacity of fully benefit from its powerful properties. By using genomic approaches and induced-pluripotent stem cell-based systems, I aim to define the regulatory architecture of TFEB activation across a broad range of cellular contexts. This will allow understanding how different regulatory mechanisms result in a cell-selective ability to preserve homeostasis and respond to various stress conditions. Specifically, I will: i) define the cell-specific dynamics of TFEB expression; ii) expose novel TFEB transcriptional regulators; iii) identify the transcriptional mechanisms underlying aberrant TFEB activation in cancer. The proposed project will be essential to define the transcriptional landscape of TFEB and will also provide a novel and yet unexplored angle to revise its contribution in disease settings where the lysosome function is impaired.

Keywords: tfeb,rna seq,cis regulatory elements,ipsc
Scientist for neurophysiological research applications in Mobile Brain/Body Imaging (MoBI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-11-01
End date: 2018-10-31
Duration (months): 12.0
Total project cost (EUR): 116500.0
EU funding (EUR): 116500.0
Participants: 1
Project status: CLOSED

Brain Products GmbH is operating in the market of neurophysiological research. For this demanding and continuously changing market, we develop and produce complex systems for electroencephalography (EEG). The next step is to enter the innovative and promising field of wearable technologies and Mobile Brain/Body Imaging (MoBI). This is an emerging research field, where increasing numbers of laboratories, institutes, universities, and companies take part. Our idea is to enter this research field – which at the same time presents a promising market for us – by connecting research institutes and, as their customers, (big) companies interested in MoBI with our company. Our aim is to develop and deliver new and innovative solutions for wearables and MoBI research. Emerging grants and preliminary market analysis suggest that for Brain Products, the MoBI market currently has a market potential of 1,5 to 2 million Euro with our existing solutions. The development of new products and applications could amplify this market potential significantly. We are applying for an innovation associate, who will be busy in strategic marketing and help us open up the MoBI market and gain market shares. The innovation associate we are looking for is a very specialised person who is not available on the German job market as – until now – there exist only three experienced laboratories in the MoBI field in Germany. However, there is a strong MoBI community in Europe and also worldwide. Due to these reasons we´d like to expand our search for a qualified scientist – and hope that the grant will give us the chance to find such a person who will open up the new „MoBI“ horizon to our company.

Keywords: mobile brain,body imaging mobi,neurophysiological research,strategic marketing,innovation associate
Global dynamics of hydro-sociality in river heritage landscapes of the Qinghai Tibetan Plateau. (HYSOTIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,New Zealand
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2024-02-11
Duration (months): 36.0
Total project cost (EUR): 251353.92
EU funding (EUR): 251353.92
Participants: 2
Project status: SIGNED

Global water challenges call urgently today for additional and deeper research by social scientists in order to achieve sustainability. By combining methods of geo-morphology and anthropology, HYSOTIB will provide an in-depth ethnographic study of one of the globe’s key river heritage landscapes – the China’s Qinghai Headwaters including the sources of the Yellow, Yangtze and Mekong rivers. The on-going transformation of the the Qinghai headwaters into a national park hinges on a profound socio-ecological paradox, where the locals (97% ethnic Tibetan) are considered by Chinese authorities as both drivers of environmental impact as well as central to local natural and cultural heritage preservation practices. HYSOTIB will disentagle the underlying dynamics of this phenomenon by investigating socio-cultural and environmental issues, thus bridging the still huge scientific gap between heritage- and water/river studies. The primary fieldwork will take place at the upper reaches of the Yangtze river in the Yushu Tibetan Prefecture (Qinghai Province). Selected case-study areas from the Three-River Source National Nature Reserve will be examined as hydro-social contexts of global encounters arising within defined ecological, ethnic and territorial boundaries. Thanks to the researcher’s knowledge in Tibetan and Chinese language, and her previous fieldwork experience in Tibetan areas of China, HYSOTIB will provide a timely and improved understanding of the global context. Urgent environmental and anthropic risks, currently at the core of the EU-China 2020 Strategic Cooperation Agenda, will be addressed. The training in river science and heritage studies at the universities of Auckland (NZ) and Ca’ Foscari in Venice (IT) will significantly cement the candidate’s status as a leading geo-social scientist.

Keywords: china,preservation of qinghai headwaters,river geomorphology,river management,natural,cultural heritage,tibetan ethnic areas,post disaster reconstruction,sustainable development
European Oocyte Biology Research Innovation Training Net (EUROVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Spain,Germany,Spain,Ireland,Belgium,Belgium,France,France,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 3970860.88
EU funding (EUR): 3970860.88
Participants: 11
Project status: SIGNED

The hallmark of successful mammalian reproduction is the fusion between a haploid spermatozoon and a metaphase II oocyte. The generation of such an oocyte involves a series of steps whereby germinal-vesicle oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature to metaphase II, a sequence of events that prepares the oocyte for fertilization. Although the treatment of infertility by Assisted Reproduction Technologies (ART) has been increasingly successful, the efficiency remains low with only about 1 in 10 eggs retrieved from women undergoing infertility treatments healthy enough to produce a pregnancy and birth. In healthy fertile livestock species, where ARTs are applied for production purposes this number increases to 1 in 6 eggs retrieved, which is still remarkably inefficient. The greatest block to advancement, is the substantial lack of knowledge on the key regulatory checkpoints and processes that determine oocyte health. Such knowledge is key not just to treating infertility and maximising livestock genetic potential and productivity, but also to the field of regenerative medicine, where the reprogramming potential of the oocyte cytoplasm is critical to reprogramming somatic genomes. The EUROVA ETN will train a consolidate European Oocyte Biology Research, train a new cohort of Reproductive scientists and generate new knowledge. A deeper knowledge and understanding of the mechanisms set in place during the trajectory of oocyte growth, maturation, fertilization and oocyte to zygote transition will lead to innovations in ART, animal breeding, endangered species preservation, regenerative medicine and reproductive toxicology.

Keywords: fertility,oocyte,embryo,reproduction,ovulation,oogenesis,oocyte development,oocyte maturation,in vitro fertilization,mouse,human
Fundamental properties and time-scan of QCD matter at high densities and temperature exposed by jet substructure in heavy ion collisions with CMS experiment at the LHC (QCDHighDensityCMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy,France,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1731406.0
EU funding (EUR): 1281246.0
Participants: 3
Project status: SIGNED

Quantum Chromodynamics (QCD) is the theory of the strong force. Its high-temperature phase can be accessed experimentally via high energy heavy-ion collisions, allowing us to investigate how the macroscopic properties of nuclear matter arise from QCD interactions between quarks and gluons. With this proposal I aim to solve several fundamental and long-standing questions concerning the strong force and the evolution of the high density phase of QCD, the Quark Gluon plasma (QGP), that are related to the evolution of the early universe: a) Characterize the transport coefficient, qhat, of the Quark Gluon Plasma, which is related to its density b) Perform the equivalent of the Rutherford experiment in the QGP, to resolve the point-like quark and gluon scatterers within the QGP. c) Provide first experimental evidence of two important interference mechanisms that are expected to play a main role in the evolution of jets in a QGP, such as the Landau Pomeranchuk Migdal effect in QCD and the color coherence effect d) Study the phenomenology of the Lund plane, in particular selections on the branching time obtained from the splitting kinematics. Can it be used to draw a time-dependent picture of the jet shower? e)Perform the first attempt to time-scan the QGP with a yoctosecond chronometer using hadronic decays of W and Z bosons. As a world leader in the field of jet physics, also with a strong phenomenological background, I am in a unique position to to solve some of the most interesting problems concerning QCD at high densities by applying new ideas and techniques and exploring the jet substructure. The CMS detector capabilities for jet and electroweak boson reconstruction and the synergy between the pp and heavy ion communities within, make of CMS the ideal experimental detector to capitalize on my ideas and existing expertise. This grant will also provide the opportunity to reinforce the european contribution to the CMS heavy ion program and lead it.

Keywords: jet physics,jet quenching
PreEclampsia diagnosis by Early Kidney Injury Detection (PREKIND)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Ireland
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-07-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Health Challenge: PreEclampsia (PE) claims the lives of 75,000 women annually and the 6,000,000+ surviving mothers will have an increased risk of cardiovascular disease for the rest of their life. PE accounts for over 500,000 infant deaths worldwide every year1; and for the millions of babies that survive, they too will go on to have increased risk of a variety of health issues. PE is a syndrome that develops during pregnancy but presents no clinical symptoms during most of the pregnancy and is therefore currently complex to diagnose. Business Challenge: With an annual spend of over 31Billion in direct costs in the developed world alone, the provision of antenatal care to pregnant women has a significant impact on health care budgets; dealing with the immediate consequences of PE form an important contribution to this cost. The Preelampsia foundation (http://www.preeclampsia.org/) estimates the annual cost of PE is more than $7billion in the US. InformBio Business Innovation: InformBio (IB) has licensed pioneering research by Dr.Vesna Garovic of the Mayo Clinic, USA. The technology has identified podocyte specific biomarkers in urine that indicate ongoing renal damage and which allow for a sub-clinical diagnosis for PE. The key biomarker, podocin, has demonstrated exceptional sensitivity and specificity and can diagnose the disease up to 3 months before clinical symptoms emerge3. InformBio are currently working to develop flow cytometry and research use only (RUO) ELISA assays for the biomarker. InformBio’s ambition is to be the world leader in early pregnancy prognostic tests, offering the most innovative, cost effective solutions to predict pregnancy complications. Phase 1 proposal: To conduct a feasibility study to support the development of a detailed business plan for the introduction of a PE diagnostic test.

Keywords: preeclampsia,podocytes,pregnancy,biomarkers
Enhanced In Situ Bioremediation for Contaminated Land Remediation (EiCLaR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Sweden,China,Belgium,Finland,France,France,Czechia,Netherlands,United Kingdom
Call: New biotechnologies to remediate harmful contaminants (RIA) (H2020-NMBP-BIO-CN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 6736278.75
EU funding (EUR): 4876278.75
Participants: 24
Project status: SIGNED

EiCLaR, as a EU/China consortium, will develop scientific and technical innovations for in situ bioremediation technologies that will be directly developed into industrial processes for the rapid efficient cost-effective treatment of a range of environmental pollutants such as chlorinated solvents, heavy metals, pesticides, etc. These technologies (Electro-nanobioremediation, innovative Bioaugmentation, Bioelectrochemical remediation, Enhanced phytoremediation) will enable bioremediation approaches to expand their range of applications to industrial sites and waters that contain complex, high concentration pollutant mixtures. This project will move our proof-of-concept level advances to industrial commercial processes through laboratories studies to refine the processes and to explore the scientific base and scale-up techniques and field demonstrations. Our recent advances in nanobioremediation will be enhanced by studies of the critical microbial component and the use of electrochemical processes to increase the degradation rate and biocatalyst lifetime. The innovative bioaugmentation is based on a recently discovered bacteria capable of degrading some chlorinated solvents efficiently under aerobic conditions. The Bioelectrochemical system will speed up the anaerobic degradation of pollutants when aeration is not feasible. The enhanced phytoremediation will benefit from the synergistic effect of fungi and electrokinetic nutrient dispersion. These environmental sustainable and low impact depollution methods will provide service companies with the tools to manage contaminated soil and water and improve environmental quality at over a million sites throughout Europe and China. These companies will be able to grow by increased personnel and revenue while improving biodiversity and reducing environmental risks.

Keywords: nanobioremediation,bioaugmentation,bioelectrochemical remediation,phytoremediation,electrokinetics,in situ bioremediation,water,soil,and groundwater,contaminant mixtures,high concentrations
Manufacturing Shock Interactions for Innovative Nanoscale Processes (NANOSHOCK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2020-11-30
Duration (months): 60.0
Total project cost (EUR): 2353438.0
EU funding (EUR): 2353438.0
Participants: 1
Project status: CLOSED

Fluid dynamics are fundamental to a wide spectrum of natural phenomena and technological applications. Among the most intriguing fluid dynamics events are shockwaves, discontinuities in the macroscopic fluid state that can lead to extreme temperatures, pressures and concentrations of energy.The violence and yet the spatial localization of shockwaves presents us with a unique potential for in situ control of fluid processes with surgical precision. Applications range from kidney-stone lithotripsy and drug delivery to advanced aircraft design. How can this potential be leveraged/harnessed? What mechanisms and inherent properties allow for formation and control of shocks in complex environments such as living organisms? How can shocks be generated in situ and targeted for drug delivery with high precision while minimizing side effects? What is the potential of reactive/fluidic-process steering by shock-interaction manufacturing? Our objective is to answer these questions by state of the art computational methods, supported by benchmark quality experiments. Computations will be based on advanced multi-resolution methods for multi-physics problems with physically consistent treatment of sub-resolution scales. Uncertainty quantification will be employed for deriving robust flow and shock-dynamic field designs. Paradigms and efficient computational tools will be delivered to the scientific and engineering community. Our group has strong foundations in complex-fluid physics and computational methods and a strong record of successfully integrating research and technical applications. Our goal is to provide un-precedented insight into shock generation and dynamics in complex environments and to unravel the path to technical solutions. Leveraging the enormous potential of manufactured shocks in situ gives access to breakthrough innovations and high-impact technologies, ranging from shock-driven nanoparticle reactors to non-invasive shock-mediated low-impact cancer therapies.