Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Insight into the Symbiotic Chemical Communication of Algae and Bacteria: Thallusin and Dedicated Analogues (THALLMORPHAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Thallusin was the first compound identified to induce thallus differentiation in macroalgae. This intriguing chemical mediator is produced by bacteria that socialize with algae in their natural habitat. Thallusin exemplifies a fundamental symbiotic chemical communication between macroalgae and epiphytic bacteria in the marine environment. However, its general impact on the underlying microbial communities and its chemical mode-of-action remains to be clarified. Therefore we propose a multifaceted research program to study the morphogenesis-inducing mechanism of algae by chemical morphogen. The proposed project will focus at four different objectives. 1) methodology development (heteroarylative/cyclization cascade), that allows the efficient and concise synthesis of thallusin. This will be achieved by ligand directed transition metal catalysis based on good literature precedent. The first objective is scheduled to be completed in first six month of the project. 2) development of novel, concise, scalable, and efficient asymmetric synthesis of (‒)-thallusin and its analogues. This will be accomplished by enantioselective polyene cyclization and heteroarylative/cyclization cascade as key steps. The second objective is scheduled to be completed from months 6-12 and 17-20. 3) structure-activity- relationships studies and 4) understanding the mode-of-action of thallusin in algae. The objective 3 and 4 will be completed in collaborations. The labeled tool compounds and dye conjugates will be synthesized from promising candidates that will allow tracing the metabolism and degradation of thallusin in algae. The 3 and 4 objective is scheduled to be completed from 9-24 months. The results that will be obtained during the course of our research will have the potential capacity to enlighten the cross-kingdom cell-to-cell chemical signaling and will provide room for further studies at the fundamental and applied levels in green algae and symbiotic bacteria association.

Keywords: algae,bacteria,morphogen,thalluisn,total synthesis,chemical biology
CROR Engine Debris Impact SHielding. Design, manufacturing, simulation and Impact test preparation (REDISH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: CROR Engine debris Impact. Shielding design, manufacturing, simulation and Impact test preparation (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2019-03-31
Duration (months): 39.0
Total project cost (EUR): 499950.0
EU funding (EUR): 499950.0
Participants: 2
Project status: CLOSED

New, eco-efficient aircrafts are challenged by a demand to significantly reduce the CO2 and NOx emission. To achieve these goals, the topic manager is exploring new configurations for integrating advanced engines and propulsion concepts to the aircraft. Most of such promising concepts as the CROR-engine, Boundary Ingestion Layer (BIL), Ultra High Bypass Ratio engines (UHBR), multiple fan cannot be targeted simply by replacing engines of the current generation, but require a substantial change of the principle aircraft configuration. In case of un-ducted engine architecture as the CROR, the rearward shift of the engines away from the wing provides additional advantages in cabin noise and passenger comfort and safety improvement. Regarding the safety, main issue is the CROR engine debris that can be release with high energy when there is a failure. It is mandatory to develop innovative solutions for panels and shielding able to shield and reduce damage at impact, to secure the airframe integrity, so that aircraft can make safe continuation of flight and landing after engine burst event. The goal of REDISH is the development and maturation of innovative shielding able to sustain impacts from high and low energy debris caused by CROR engine burst. A coupled experimental-numerical development approach at two structural scales (laminate/panel and component) is proposed that starts from a large pool of possible configurations that will be downselected in successive analysis steps of increasing detail. Virtual testing by means of high-fidelity simulation tools developed by the consortium will be used to decrease the need for costly physical testing as much as possible and accelerate the shielding development process. The specimens to be manufactured and tested are the ones strictly necessary to validate the numerical simulations and assure the highest educated selection of the actual solution to be implemented for CROR Engine Debris Impact SHielding.

Keywords: counter rotating open rotor,impact shielding,composite materials,ballistic impact,impact resistance,damage tolerance,finite element analysis,virtual testing,failure,progressive damage
Accelerating HIV Cure in Europe (EU4HIVCURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Belgium,France,Canada
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 328500.0
EU funding (EUR): 310500.0
Participants: 7
Project status: CLOSED

Finding a CURE for 35 Million individuals living with HIV/AIDS is one of the great global health challenges of the 21st century. The major obstacle to HIV eradication is the persistence of latent HIV cellular reservoirs, where the integrated viral genome is transcriptionally silenced but replication-competent and can escape both Anti-Retroviral Therapy and Immune Responses. The development of novel strategies aimed at eliminating these reservoirs have become paramount in HIV research, if we want to achieve an HIV/AIDS CURE. To accelerate the State of the Art in HIV CURE research in Europe, our EU4HIVCURE consortium brings together an intersectoral and interdisciplinary collaboration between 3 Universities, 3 Hospitals, 1 International Research Organisation from 4 European countries and 1 University from Canada. Our aim is to dissect the intricate mechanisms controlling HIV-1 latency and identify new druggable targets to develop novel latency-reversing strategies and eradicate persistent viral reservoirs by forcing HIV-1 gene expression. To facilitate continuum for translation to the clinic, we have developed an operational framework, which maximises exchange of knowledge and expertise via secondements, networking and training activities.

Keywords: hiv post integration latency,hiv persistent reservoirs,hiv cure,translational research,preclinical studies,new classes of latency reversing agents,innovative hiv reactivation strategy
Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain dUring Sleep-wake cycle (MoRPHEUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-16
End date: 2024-05-15
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and recovery can constitute a key factor to advance treatment. Within this framework, the primary goal of this project is to devise and test a novel neuroprosthetic approach that monitors brain activity and the sleep-wake cycle (SWC) in order to deliver responsive and engineered electrical stimulation (ES) coded in time. To do this, we aim to: 1) investigate SWC architecture in animal models of brain lesion to better understand pathological modifications and to find privileged windows of neural plasticity to deliver therapeutic ES; 2) design, build, and test a closed-loop system capable of recording, processing and detecting SWC stages and electrographic events of interest (e.g. spindles), and also of delivering coordinated ES, including activity-dependent and time-coded stimulation, and; 3) evaluate the designed approach regarding its efficacy in providing long-lasting, robust, and safe motor rehabilitation to injured animals, while also obtaining a proof-of-concept in humans. Highly complementary skills from fellow and host will cooperate to carry in vivo electrophysiology experiments and technological development, while translational pilot experiments will be performed in close collaboration with partners in the medical field. Finally, secondments will provide additional training on state-of-the-art engineering of closed-loop systems and entrepreneurship in neurotechnology.

Keywords: closed loop systems,motor disorders,motor rehabilitation,neuroprosthesis,sleep,stroke,traumatic brain injury
Validation of clinical performance and pre-commercial development of a novel diagnostic for dental caries assessment (Calcivis CAIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 2975531.25
EU funding (EUR): 2615000.0
Participants: 1
Project status: CLOSED

The project will support development of the market ready version of the Calcivis Caries Activity Imaging System (currently in advanced prototype form) and validate its clinical performance against existing standards, which will enable first EU launch within one year of funding and US launch within two. The Calcivis technology is a highly innovative and globally significant dental diagnostic which has the capability to enable and accelerate the ongoing paradigm shift towards preventive dentistry. Uniquely it uses a recombinant photoprotein marker and a sophisticated imaging device to detect free calcium ions at the tooth surface, to provide diagnostic and prognostic information on the development and progression of caries lesions (tooth decay). There is a significant unmet need in dentistry to differentiate early caries lesions that are actively demineralising from those that are less likely to progress to cavitation. Current state of the art is subjective visual/tactile examination which leads to active lesions being missed and inactive lesions being unnecessarily restored. Dental practice is gradually moving towards diagnosis/prevention and away from automatic ‘drill and fill’ approaches; a shift which will be further enabled by the Calcivis System. It is the only product that can directly detect ongoing demineralisation in the clinic which enables: - differentiation of active from inactive lesions - early detection of incipient active lesions - monitoring of therapeutic effectiveness i.e. ‘switching off’ of activity To date, a prototype of the Calcivis System has been used to demonstrate proof of concept in extracted teeth and is now undergoing a pilot safety and performance clinical study. The clinical prototype was granted a CE mark in December 2013. The results of this clinical study and ongoing market research are being used to support design of the commercial device and the full clinical validation programme, which is the subject of this application.

Keywords: dental caries diagnosis prognosis demineralization calcium ions lesion activity imaging
The values of French language and literature in the European Middle Ages (TVOF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-01-31
Duration (months): 65.0
Total project cost (EUR): 2274225.0
EU funding (EUR): 2274225.0
Participants: 1
Project status: CLOSED

Two questions about linguistic identity lie at the heart of this project. What is the relation historically between language and identity in Europe? How are cognate languages demarcated from each other? Normative models of national languages helped shape Europe. Yet they did not become hegemonic until the 19th century. Indeed, they were imposed (not always successfully) on a linguistic map of Europe more fluid and complex than most histories of national languages allow. In the Middle Ages multilingualism was common, as was the use of non-local languages, notably Latin, but also French. This project undertakes a revaluation of the nature and value of the use of French in Europe during a crucial period, 1100-1450, less in terms of its cultural prestige (the traditional focus of scholarship) than of its role as a supralocal, transnational language, particularly in Western Europe and the Eastern Mediterranean. The project fosters collaboration between, and cuts across, different intellectual and national scholarly traditions, drawing on expertise in codicology, critical theory, linguistics, literature, and philology; it involves scholars from a range of European countries and North America, entailing empirical research around a complex and widely disseminated textual tradition vital to medieval understandings of European history and identity, L’Histoire ancienne jusqu’à César. This case study will ground and stimulate broader speculative reflection on the two core questions concerning linguistic identity. While the project builds on prior critiques of the construction of, and investment in, national languages and literary traditions, it has a broad historical scope, and will offer an innovative, genuinely international perspective, in terms of both its object of study and method. Indeed, its final aim, through and beyond its consideration of French as a lingua franca, is to interrogate that language’s role in the emergence of a European identity in the Middle Ages.
EEN Northern Netherlands: enhancing the innovation capacity of SME's (EEN Northern NL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Netherlands,Netherlands
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 82750.0
EU funding (EUR): 82750.0
Participants: 5
Project status: CLOSED

In addition to the innovation-related services offered by EEN Northern Netherlands, this H2020 project will provide in-depth services enhancing the innovation capacity of SMEs. Due to several reasons (f.e. a lack of offers, unaffordable market prices or poor quality), consulting service offers enhancing the innovation management capacity of companies are not readily available to SMEs in many European regions, including the Northern Netherlands. This specific Horizon 2020 activity within the EEN services therefore offers mentoring and coaching services to beneficiaries with the objective to increase and accelerate economic returns from innovation. The EEN Northern NL consortium addresses this specific challenge with two service packages: 1. Key account management services for H2020 SME instrument beneficiaries: By offering key acount management services to beneficiaries of the H20202 SME instrument it will be possible to support these SME’s in their innovation process and enhance their innovation capacity. 2. Services to enhance the innovation management capacities of SMEs: particularly promising SMEs will be supported by the enhancement of their innovation management capacities. This will be done by carry out a diagnostic audit of selected SMEs that are capable of growth and successful internationalisation in order to develop and implement a tailored action plan to improve the SME’s capacity to manage innovation processes. Within the consortium expertise and knowledge on internationalisation and innovation is pooled together to offer SME's expert information, advice and coaching. This project focusses on the selection of promising SME’s within in the region and enable them to enhance their innovation capacity under the supervision of experienced innovation coaches.

Keywords: innovation management,innovation capacity,innovation support,coaching,mentoring,h2020 sme instrument
Marine microalgae-based functional foods and food supplements for the prevention of chronic diseases (TetraFOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FITOPLANCTON MARINO S.L. (FM) is one of the European leading companies in marine microalgae production and is the first microalgae production company in achieving the European Novel Food approval for the marine microalgae species Tetraselmis chuii. The company, currently involved in microalgae production for aquaculture, cosmetics and human nutrition, aims to position itself as a leading company in the production of high-value bioactive compounds for the food sector. Building on the results of previous research work conducted by the company, FM aims to use T. chuii as a natural biofactory for the production of high value bioactive compounds with potential to improve health and reduce the risk of chronic diseases. FM will commercialise a food supplement based on whole microalgae T. chuii and an innovative extract rich in bioactive compounds to be used as functional food ingredient. Currently, no commercial product based on T. chuii is available in the market. Potential clients are nearly 170 companies currently involved in the elaboration of functional foods, and potential end-users include general consumers willing to prevent health issues and men and women suffering from health risk factors influenced by diet. The feasibility assessment is structured in three main components: a) detailed market analysis; b) feasibility assessments at the economic & financial, technical and legal & regulatory levels; and c) elaboration of a Business Innovation Plan II setting the strategies (in terms of product development, commercialisation, financing, management of IP rights,...) to bring the marine microalgae-based products to industrial readiness for market uptake. The project will permit to provide European consumers with new innovative functional ingredients and food supplements with proven benefits on health whilst contributing to foster the positioning of Europe as a leading region in the production of marine microalgae-based products for the food sector.

Keywords: microalgae,functional ingredients,food supplements,chronic diseases
World RePORT Refresh, the Global Biomedical Research Project Database, Technology and Functionality, 2017 (Phase 2) (World RePORT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Coordination and support actions
Countries involved: United States
Call: Grant to map the biomedical research projects funded by major funding organisations around the World (H2020-IBA-SC1-BIOMEDICAL-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 69125.0
EU funding (EUR): 69125.0
Participants: 1
Project status: CLOSED

The World RePORT is a database mapping the biomedical research projects supported by the major funders. It illustrates where the research is taking place. The World RePORT had an initial Pilot Phase focused only in sub-Saharan Africa (2011 – 2013). This initial version was upgraded in 2016 to make it more user-friendly and easier to search, with charts to summarize the information; to include all the regions of the World; to improve search; to add automatic statistics; to include filters to highlight research in Low and Middle Income Countries (LMICs); and to improve performance in accommodating the larger number of records (Phase 1). Phase 1 was intended to enhance and upgrade the existing World RePORT beta website and database. The overall objective of Phase 2, presented in this proposal, is to enhance the user experience by adding a rich interface and an integration mechanism/workflow for funding organizations to upload their own data, and to add more visualizations and other enhancements, while keeping the overall site responsive to and compliant with the latest technologies.

Keywords: data visualizations,user interface ui,user experience ux,data load tool,website,database,functional software,analysis report,biomedical research,project management,agile