Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting host-transposon interactions during germline development and their impact on genome integrity (TE-Time)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Mammalian genomes are filled with transposable elements (TEs), whose activity is usually silenced by DNA methylation. However, during the fetal phase of germline development, DNA methylation is naturally lost as part of the epigenetic reprogramming of the future gametes. This leads to the transcriptional activation of transposition-competent TEs, which normally represents a threat to genomic integrity and species fitness. How fetal male germ cells (a.k.a. prospermatogonia) mechanistically cope with TE reactivation and protect the integrity of the genetic material? Preliminary data from the lab indicates that TEs acquire both permissive H3K4me3 and repressive H3K9me3 marks in mouse prospermatogonia, and may be subject to early transcription termination. I will investigate whether these regulatory patterns may allow prospermatogonia to tolerate active TEs and even integrate them into their own developmental program. Focusing on this unique cellular model provided by prospermatogonia, I will 1) assess the dynamics of H3K4me3-K9me3 marks using single cell multimodal chromatin profiling in relation to prospermatogonia development, 2) analyze TE transcriptional features, 3) study the 3D coordination of TE regulation within the nucleus and 4) investigate whether TEs participate to the prospermatogonia gene expression program by providing regulatory sequences. I believe this project will identify novel principles in TE regulation with immediate relevance for the field of reproductive biology. Knowledge will be gained regarding the origin of infertilities, but also for other pathological contexts such as cancer and neurodegenerative diseases, whereby DNA methylation loss and TE reactivation are commonly observed.

Keywords: transposable elements germline development epigenetic reprogramming transcriptional regulation chromatin
Enhancing social well-being and economic prosperity by reinforcing the eFFECTIVEness of protection and restoration management in Mediterranean MPAs (EFFECTIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Spain,Cyprus,Netherlands,Ireland,Austria,Greece,Italy,Denmark,Germany,Ukraine,Bulgaria,United Kingdom
Call: European Blue Parks – Protection and restoration solutions for degraded coastal and marine habitats (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 9434729.75
EU funding (EUR): 8197136.0
Participants: 22
Project status: SIGNED

The EFFECTIVE main objective is to develop a comprehensive scientific knowledge base and practical guidance, combining science, technological nature-based solution, digitalization, and social implication for the application of the Ecosystem-Based management to the protection and restoration management of the EU’s Mediterranean Blue Natural Capital. To ensure the success of this main objective, the EFFECTIVE project counts on partners with broad expertise in relevant areas covering all the three pillars of the EBMS (from applying research stages until companies) as follows: managerial pillar, information pillar, and participation pillar and also a nature-based solution. In addition, this project provides the implementation of the EBMS in four pilot areas (Mar de l’Empordà, Ebro Delta, Sardinia Septentrional, Cavo Greco) towards protection and restoration solutions, besides taking into account the connectivity between three of them through the existing Cetacean Migration Corridor. To achieve the EFFECTIVE main objective, the following 5 specific objectives (SO) are identified: SO 1. Apply EBMS to identify, analyze and extend an ecological corridor in the Mediterranean Sea, connecting habitats and biodiversity. SO 2. Apply EBMS to analyse and extend the status of [4] MPA in the Mediterranean Sea. SO 3. Demonstrate [4] nature-based seabed protection and restoration solutions, including preserving seabed carbon sequestration capacity, in a real environment. SO 4. To identify limiting factors, gaps and recommendations of existing MPA legislation regarding environmental and anthropogenic pressures, setting up links with previous projects. SO 5. To implement an innovative digital data visualization and aggregation tool in the form of a Digital Twin for enabling data exploration, research, participation and citizen science.
Exploring Consumer Behavior in the Digital Age: Insights from Theory-driven, Large-scale Randomized Field Experiments on Mobile Data Alerts and Data Breach Announcements (DALE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

DALE addresses an urgent need to advance research on consumer behavior, namely consumers’ responses to the timing of mobile data scarcity messages and data breach announcements, using a multi-method approach composed of theoretical models and large-scale randomized experiments (RME). DALE builds upon research from information systems, behavioral economics, operations, and marketing to build more effective tools to improve consumption efficiency and mitigate the repercussions of cyberattacks. First, DALE builds a theoretical framework of how behavioral nudges in a resource scarce setting improves consumption efficiency and shows that in contrary to conventional wisdom sending warnings as early as possible may lead to higher chances of data shortages, a finding that highlights the importance of an under-investigated aspect, namely the timing of alerts. Based on the above, the project complements the study with a RME in partnership with a leading telecommunication provider. Interlinked with the ever-increasing data consumption needs, is the problem that the very same data we leave behind may be breached. The second phase investigates how consumers react to data-breach announcements. I build a theoretical framework of how consumer shopping behavior may change in response to such breaches and test these predictions with a four-year granular dataset provided by a multi-channel grocery partner. DALE will provide practical cross-sectional, interdisciplinary interventions for use by academia, policymakers, and business. My training, supervised at IESE Business School, will allow me to hone new academic and non-academic skills and fulfill my career ambitions: a) Become a renowned researcher with top-level, influential connections to industry and public entities; b) Position me as an interdisciplinary, cross-sectoral expert on consumer behavior in the digital world, poised for achieving tenure track goals and decision-influencing leadership in non-academic settings.

Keywords: consumer behaviour,large scale randomized experiments,causal inference,theoretical modelling,e commerce,grocery,telecommunication,offline online markets
Missionary Engagements, Extractive Histories, and Indigenous Land (MEEHIL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

This research project aims to study the entanglements and discrepancies between indigenous understandings of history and colonial narratives created by missionary intervention amongst the Shuar people of lowland Ecuador. It will examine how history, indigenous memory, and cultural transmission have been developed and produced in the context of missionisation and colonial pressure. It aims to understand how colonial history still impacts indigenous politics today, shaping current indigenous engagements with large-scale resource extraction and allowing extractive capital to endure and perpetuate over time. To achieve these objectives, this research reviews the historical archives available in the region from the Salesian and Franciscan missions since the late 19th century, will collect and archive film footage of testimonial memories from indigenous participants on their complex relationship with the missionary endeavours and boarding schools, and will map how missionary presence shaped indigenous land. The use of these three different methodologies will be combined to provide a clear ethnographic study that aims to understand and describe the long-term effects of colonial entanglements on people’s attitudes, thinking, and current political developments. Overall, this research project is concerned with colonial residues and proposes to look at land demarcation, history, and cultural transmission to understand not only the impacts of colonialism in its tangible political ubiquity but also in its pervasive and intangible influence over concepts that help people define their worldview.

Keywords: colonization,social change,boarding schools,history,indigenous memory,missionary archives
LEO satellite-based Integrated Localization and Communications for 6G networks (LILAC-6G) (LILAC-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Integrated localization and communications (ILAC) is a key feature of the future sixth-generation (6G) network. Benefiting from wide coverage and flexible deployment, operating ILAC in low-earth-orbit (LEO) satellite systems is a promising way to provide ubiquitously flexible localization and high-capacity communication. Particularly, in terms of localization, LEO satellite systems can break through limitations of global navigation satellite systems (GNSS) and provide superior signal quality for ILAC service. Although the LEO satellite systems are crucial for future 6G networks, they also bring challenges. First, the current signal waveforms for LEO satellite systems are primarily optimized for communication purposes, which may fail to meet the requirements of ILAC in the 6G networks. Second, the high mobility of LEO satellites leads to time-varying channels and significant Doppler shifts in satellite-ground links. Conventional positioning methods, generally tailored for terrestrial signal waveforms and assuming linear time-invariant channels, will be suboptimal in this new scenario. To address these challenges, this research aims to develop novel integrated localization and communication methods tailored for 6G LEO satellite systems with time-varying channels. To this end, three work packages (WPs) are conducted. WP1 is to design advance signal waveforms for integrated localization and communication in 6G LEO satellite systems and conduct a performance analysis considering the time-varying channel. WP2 is to develop advanced LEO satellite-based localization and tracking algorithms for moving targets. WP3 is to develop adaptive resource allocation and satellite handover algorithms for ILAC with multiple LEO satellites. This project aims to develop innovative integrated localization and communications techniques for 6G LEO satellite systems, facilitating precise positioning and high-data-rate communications for moving targets.

Keywords: 6g localization,integrated localization and communications,low earth orbit leo satellite systems
TRAVELLING IONOSPHERIC DISTURBANCES FORECASTING SYSTEM (T-FORS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Spain,Belgium,Bulgaria,Czechia,Germany,Hungary,France
Call: Space Weather (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 999750.0
EU funding (EUR): 999750.0
Participants: 10
Project status: CLOSED

Travelling Ionospheric Disturbances (TIDs) constitute a specific type of space weather disturbance affecting the performance of critical space and ground infrastructure by disrupting operations and communications in multiple sectors. T-FORS aims at providing new models able to interpret a broad range of observations of the solar corona, the interplanetary medium, the magnetosphere, the ionosphere and the atmosphere, and to issue forecasts and warnings for TIDs several hours ahead. Machine Learning techniques are used to train the models based on existing databases developed in the frames of past Horizon 2020 projects, to estimate the occurrence probability of medium scale TIDs and to forecast the occurrence and propagation of large scale TIDs. Prototype services are developed based on specifications from the users' community and following harmonized standards and quality control similar to the best practices of meteorological services. On ground demonstration tests are organised, by aerospace and civil protection agencies, to validate the performance of the T-FORS prototype services. A comprehensive architectural concept is proposed, including the densification of ground instrument networks, and new space missions, and possible future adjustments in order to develop a real-time operational service fully compliant and complementary to the ESA Space Weather services.

Keywords: ionosphere,space weather,space situational awareness,travelling ionospheric disturbances
Implantable microroBOT (I-BOT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1497923.75
EU funding (EUR): 1497923.75
Participants: 1
Project status: SIGNED

Small-scale medical robotics was born from a science fiction vision: shrinking down a group of surgeons and letting them swim to the brain to save a patient’s life. This vision calls for precision, efficiency in delivering force and noninvasiveness. Conversely, the microrobots proposed so far are only able to perform drug or cell delivery. Furthermore, their capability to keep an active configuration is strictly dependent on the presence of a certain external stimulus. In this ERC project I aim to tackle these challenges by devising new actuation mechanisms, control and imaging strategies allowing the microrobots to exert suitable forces and prolonging their lifetime. I-BOT proposes the first generation of implantable microrobots featured by a multi-material structure including a liquid perfluorocarbon core and a shape memory polymers magnetic composite skin. By exploiting magnetic material programming, microrobots will be capable of multimodal locomotion under magnetic guidance. Upon target reaching, low intensity pulsed ultrasound and alternated magnetic fields will trigger acoustic droplet vaporization and magnetic hyperthermia. This will produce simultaneous volumetric expansion of the internal chamber and deformation of the surrounding skin to allow fitting the implant site. Shape memory polymers will ensure shape locking upon removal of the triggering signals thus stable implant. Ultrasound acoustic phase analysis will allow microrobot tracking over the entire implant procedure and prolonged lesion monitoring upon implantation. The I-BOT approach will be validated in three relevant validation scenarios (ulcer filling, vascular graft and long term tumoral lesion monitoring) to demonstrate the flexibility of the approach and to unveil the potentialities and the impact of implantable microrobots. As a final step, the most promising validation scenario will be tested in vivo in large animals, as a step forward in moving microrobots from the bench to the bedside.

Keywords: microrobotics,medical robotics,ultrasound triggering,magnetic locomotion
CRYOsphere-Ocean: Effect on the MIcrobial Communities in the Southern Ocean (CRYOMICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

The melting of the cryosphere is among the most conspicuous consequences of climate change, and a significant source of freshwater to the Southern Ocean (SO). As a crucial sink for atmospheric carbon dioxide (CO2), anticipated physical changes in the Southern Ocean will bring modifications to its biogeochemical processes and role in the Earth climate. Predicted increases in iron and nutrient influx to the SO surface waters are likely to impact its primary production and contribution to biological carbon export. However, there remains uncertainty about the significance and magnitude of these projections on primary producers, with likely consequences on the rest of the marine ecosystem. CRYOMICS aims to characterise and quantify the fate of cryospheric exported bioavailable nutrients, trace metals and carbon on phytoplankton utilisation pathways with broader implication on the functioning of the biological carbon pump in the KHS. We hypothesise that biogeochemical enrichment from melting ice shelves leads to a direct positive response of the phytoplankton and sea ice algae community, enhancing its productivity and metabolic functions while favouring larger-celled species such as diatoms. Focusing primarily on the understudied Kong Håkon VII Sea (KHS) in the Eastern Weddell Gyre, along a unique cryosphere-ocean continuum, CRYOMICS combines intensive sampling, biogeochemical analyses and metagenomics to systematically understand the structure and function of microbiomes in marine ecosystems associated with the cryosphere and amidst contemporary changes. Through the support of the MSCA, this project will provide a coordinated and comprehensive dataset of this region of the Southern Ocean, shedding light on microbial interactions and their potential vulnerabilities to perturbations, a dimension currently lacking in climate models. This invaluable insight will enhance our understanding of future projections for the Southern Ocean, including its impact on Antarctic Sea ice.

Keywords: cryosphere southern ocean primary production nutrients iron metagenomics functional traits
Enhanced X(cross)-disciplinary Community-driven Imaging Technologies for Earth and Environmental material research (EXCITE2)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Germany,Spain,France,Norway,Portugal,United Kingdom,Italy,Czechia,Australia,Hungary,Finland,Slovenia
Call: Research infrastructure services to enable R&I addressing main challenges and EU priorities (HORIZON-INFRA-2023-SERV-01, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 14360285.75
EU funding (EUR): 14360285.75
Participants: 22
Project status: SIGNED

The EXCITE² Network is revolutionizing Earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 European and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies. This enables scientists to decipher complex processes within Earth materials at scales from nanometres to hundreds of centimetres, gaining unparalleled insight into the chemical and physical processes that govern, among others, environmental toxicity and its impact on human health, critical metal extraction for renewable energies, and the utilisation of Earth materials as long-term storage for climate-altering gases. The consortium fosters knowledge-sharing and talent attraction, bolstering the problem-solving capacity of the European Research Area. Moreover, EXCITE² is driving interdisciplinary collaboration and cross-fertilisation across academic institutions, scientific disciplines, and industry, propelling Europe towards a sustainable future. The initiative offers dedicated training programmes to a new generation of researchers within the European open science landscape, paired with access to world-class imaging facilities and expertise for problem-solving research and innovation. EXCITE² is introducing innovative service developments, such as artificial intelligence and leading-edge imaging experiments, to increase the user's problem-solving capacity. In addition, the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia, society, and the economy. Citizen science projects allow the public to participate directly within the EXCITE² Network, contributing to solving EU challenges. As such, EXCITE² is paving the way towards a sustainable future, driving scientific excellence, and creating positive societal impact.

Keywords: electron microscopy,x ray microscopy,earth and environmental materials