Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Re engineering and regenerating the knee (REGENKNEE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Products and process engineering
Countries involved: United Kingdom
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-04-01
End date: 2016-03-31
Duration (months): 60.0
Total project cost (EUR): 2495134.3
EU funding (EUR): 2495134.3
Participants: 1
Project status: CLOSED

Over fifteen percent of the western population suffer from osteoarthritis. For severe disability, total joint replacement remains the onlty treatment. The ageing population is growing and their expectations for an active, high quality lifestyle is increasing. The number of knee joint replacements is predicted to increase five time by 2025. While technology for knee joint replacements has advanced considerably over the last decade, knee joint replacements do yet restore the natural function or provide the longevity expected for a population expecting - fifty more active years after fifty. An alternative is needed. We wil address the potential of regenerative biological scaffolds to re-engineer and regenerate the knee in early stage degenerative disease. We will build upon our successful research and clinical trials in the application of regenerative biological scaffolds in the cardiovascular system.. We will research and develop bioprocesses to produce a portfolio of tissue specific regenerative biological scaffolds to replace disrupted and degenerative tissues in the knee, including ligaments, meniscus, bone and cartilage. and evaluate their biomechanical, biotribological and biological function. We will investigate the regenerative potential of these novel biological scaffolds individually and collectively in the knee as a bioengineering system. This research will open the opportunity for a paradigm shift for treatment of degenerative disease in the knee and offer the potential for substantially delaying the need for a joint replacement in hundreds of thousands of patients every year.

Keywords: biological scaffolds knee repair biotribology biomechanics
CNIC INTERNATIONAL INCOMING FELLOWSHIPS FOR YOUNG GROUP LEADERS (CNIC IIF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2011-10-01
End date: 2015-09-30
Duration (months): 48.0
Total project cost (EUR): 6057847.8
EU funding (EUR): 2423139.12
Participants: 1
Project status: CLOSED

The CNIC IIF Programme will offer a total of 24 positions during the COFUND programme life (four years) in the incoming mobility type in the area of cardiovascular research. Every year six fellowships will be offered at the level of young group leaders: 4 Starting Fellowships (SF) and 2 Advanced Fellowships (AF). In both cases, the duration of the fellowships will be 3 years and have particular objectives both in research training and overall career development. The fellowship will include a research project prepared by the research fellow in coordination with the CNIC research department of choice, tailored to the needs of the researcher to allow him/her to reach a realistic and well-defined objective in terms of gaining new experience to strength his/her new leading independent position (leading research projects, management and organisational skills, building collaborations, student’s supervision, etc.).

Keywords: health sciences
Empa international postdoctoral fellowship programme (EMPAPOSTDOCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2011-11-15
End date: 2016-11-14
Duration (months): 60.0
Total project cost (EUR): 9579810.24
EU funding (EUR): 3831924.09
Participants: 1
Project status: CLOSED

Empa, a world-class industry-oriented research institution part of the Swiss Federal Institute of Technology Domain, has decided to create a new fellowship programme, the Empa international postdoctoral fellowship programme. EMPAPOSTDOCS is an individual-driven bottom-up incoming trans-national mobility and re-integration programme. It will allow experienced researchers from all over the world to create a research project and get the opportunity to work on their own research idea at one of the 29 research laboratories of Empa, in cooperation with a senior scientist already working at Empa of his choice. Empa’s five research programs and three locations offer a large degree of freedom of research topic and destination for the applicants. The applicants will be evaluated by an internal and external selection committee of peer-reviewers according to strict selection criteria focusing on the applicants’ professional, personal, social and leadership skills and his or her research potential. The fellows will be offered an Empa contract of two years. They will have the opportunity to improve their management skills by leading research projects. Being an EMPAPOSTDOCS fellow thus constitutes a good preparation for science and engineering management positions in the industry and for work in start-ups. The support schemes and career development tools, which include training in scientific and non-scientific skills, will insure that the stay of the fellows at Empa was beneficial for the development of their career. The highly competitive living allowance, research cost contribution and mobility package offered by EMPAPOSTDOCS will surely draw a fair amount of non-European applicants, while ensuring that the best European researchers stay within the ERA. The inclusion of a re-integration scheme also works in this direction, making EMPAPOSTDOCS’ goals directly in line with the overall objective and expected impact of the COFUND action.

Keywords: natural sciences,technological sciences,physical sciences
Nanomachines based on interlocked DNA architectures (DNA MACHINES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Germany
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-03-01
End date: 2016-02-29
Duration (months): 60.0
Total project cost (EUR): 2499522.0
EU funding (EUR): 2499522.0
Participants: 1
Project status: CLOSED

DNA-nanotechnology has created different topologies, including replicable ones, nanomachines, patterns, logic gates, or algorithmic assemblies. Interlocked double-stranded (ds) DNA-architectures like catenanes or rotaxanes, wherein individual components can be set in motion in a controlled manner have not been accessible. These molecules represent long-sought devices for nanorobotics and nanomechanics because they possess a unique mechanical bonding motif, not available to conventional building blocks. The project will apply an unprecedented, simple, and modular interlocking paradigm for double-stranded (ds) circular DNA geometries that we have developed in preliminary studies. This will now be taken several crucial steps forward by generating unconventional DNA-, protein-, aptamer-, and ribozyme hybrid architectures containing interlocked structures wherein the motion of individual components can be controlled in many different ways. We will design, construct, and evaluate switchable autonomous DNA-nanomachines that function as rotational motors, muscles, or switches for powering and manipulating nanoscale components. The DNA machines envisaged in this project will be applied, for example, in synthetic supramolecular self-assembly systems that emulate complex biological machines like motor proteins, nucleic acid polymerases, or ATPases. In addition, they will be developed for multiple purposes in biosensing, logic-gate- and memory circuit assembly, and catalysis. This efficient method for constructing interlocked dsDNA nanostructures opens the exciting possibility of conjoining the area of lifesciences with that of nanomechanical engineering, paving entirely new avenues for nanotechnology. The project is highly interdisciplinary and will open a new field with enormous innovative potential and implications ranging from chemistry to synthetic biology, and from the life sciences to nano-engineering.

Keywords: chemical biology dna nanoarchitectures molecular machines
Determinants of mandibular form during intra-oral food processing (MACACA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-12-01
End date: 2012-11-30
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Whilst the biomechanical determinants of a chewing cycle are essential components of the primate feeding system from an evolutionary and a clinical perspective, lack of experimental studies have resulted in the construction of oversimplified and biologically inconsistent computer simulation models. Such models have been employed to answer hypotheses regarding feeding biomechanics and dietary ecology of extinct and extant species, leading to questionable results. This study applies the most complete bone strain, bite force, jaw optico-kinematic, and electromyographic data to a series of finite element models of a M. mulatta mandible to simulate a complete chewing cycle. The main objective is to estimate stress and strain concentrations on the mandible during molar, premolar and incisor biting when processing food particles that vary in their material properties. The accuracy of the FE models will be tested by conducting a series of sensitivity analyses regarding bite locations. The models will then be validated against experimental in vivo bone strain data. A series of statistical analyses will be also employed to study strain magnitudes and orientations in the primate mandible in relation to loading and unloading times, chewing rates, chewing frequencies and gapes. It is hypothesised that strain magnitudes, patterns and orientations will be highly sensitive to different biting cases and dependent on the food particles consumed and the chewing frequencies employed. The results will give new insights into the nature of the stresses and strains the primate mandible undergoes during a chewing cycle and will indicate how strong the mandible is in relation to the functional stresses it experiences. We will then, with unprecedented rigour, illuminate a level of mechanistic explanation of why many non-human primates in captivity develop pathologies in the mandible related to masticatory stresses and to an inappropriate diet.

Keywords: feeding apparatus,finite element modelling,primate mandible,force modulation,intra-oral food processing
PEGASUS - giving wings to the career of experienced researchers (PEGASUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2012-02-01
End date: 2016-07-31
Duration (months): 54.0
Total project cost (EUR): 12450673.0
EU funding (EUR): 4980269.2
Participants: 1
Project status: CLOSED

The Research Foundation Flanders (FWO) supports basic research in all scientific domains through a range of funding instruments tailored to the needs of researchers at different stages in their careers. With support from the European Commission, the FWO intends to increase the internationalisation of research activities in Flanders and contribute to the implementation of the ERA vision by setting up a programme, co-funded by Marie Curie Actions, called PEGASUS, giving wings to your career. The programme will attract talented experienced researchers to Flanders, not only to participate in research but also to transfer knowledge and contribute substantially to their career development. The PEGASUS programme will be targeted on experienced researchers working abroad and expand the existing fellowship programme of the FWO. Applicants can be of any nationality and any scientific background. Selected fellows will be offered the same employment conditions as resident researchers and will be provided with excellent career development and training opportunities, all in line with the European Charter and Code. The PEGASUS programme will include a 1-year and 3-year incoming fellowship scheme. The 1-year scheme is to replace the existing visiting postdoctoral fellowship programme of the FWO and will raise the standards of this programme with respect to selection procedures and appointment conditions of the fellows. The 3-year scheme intends to open up and expand the current fellowship programme of the FWO to attract a larger number of experienced researchers to Flanders. The main aim of the co-funded PEGASUS programme is to realise an effective knowledge transfer between incoming fellows and resident researchers, creating future networking opportunities and enhancing the career development and perspectives of the fellow, to the benefit of both the incoming fellow and the research community in Flanders and Europe.

Keywords: international,incoming fellowships,experienced researchers
ExoMol: molecular line lists for exoplanet atmospheres (EXOMOL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: United Kingdom
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 2472032.0
EU funding (EUR): 2472032.0
Participants: 1
Project status: CLOSED

The discovery of extrasolar planets was one of the major advances of the last two decades. Over 400 planets have now been detected and astronomers are beginning to characterise their composition and physical characteristics. To do this requires huge quantities of spectroscopic data most of which is not available from laboratory studies. The interdisciplinary ExoMol project will provide a comprehensive solution to this problem by providing spectroscopic data on all the molecular transitions of importance in the atmospheres of exoplanets. This data will be widely applicable to other problems and will be used for studies on cool stars, brown dwarfs and circumstellar environments. ExoMol will also be used by scientists who study spectra of hot molecules in a other situations such as combustions. A mixture of first principles and empirically tuned quantum mechanical methods will be used to compute comprehensive and huge (up to 100 billion transitions) line lists. Novel methodologies will be developed for treating larger molecules such as methane and nitric acid. The success of ExoMol will rely on these developments and the use of state-of-the-art computing. The ExoMol database will from part of the EU Virtual Atomic and Molecular Data Centre (VAMDC). A program to promote application of the data by a wide variety of users will be initiated.

Keywords: extra solar plants,molecular spectroscopy,brown dwarfs,cool stars,circumstellar
Talentia fellowships for experienced postdoctoral researchers in all areas of knowledge and committed to innovation and sustainable development (TALENTIA POSTDOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2011-05-01
End date: 2016-10-31
Duration (months): 66.0
Total project cost (EUR): 3020328.64
EU funding (EUR): 1208131.46
Participants: 2
Project status: CLOSED

Objectives The objective of the Talentia Postdoc Fellowship is to stimulate and support excellent experienced researchers to further develop their careers without mobility restrictions and with complete freedom of choice of their research field, while remaining connected, at all times, to the European Research Area. The results of their research should lead to significant improvements in the areas of innovation, technology transfer and entrepreneurship; and desirably, in the productivity and sustainable development of Europe through the modernisation of its SMEs and traditional manufacturing industries, an issue of particular relevance in Andalusia, Spain, where Talentia is based. Implementation A new scholarship program launched by Talentia will contribute to the achievement of these goals. Talentia is a public body in charge of human capital development and international mobility created and supported by the Regional Government of Andalusia, in Spain. It was created in 2006 and runs under the supervision of the Regional Ministry of Innovation, Science and Enterprise. Talentia currently manages a fellowship program for Masters and Phd degrees. Within this framework, Talentia now aims to launch a new program addressed to Postdoctoral candidates, outstanding researchers who presumably will not feel sufficiently stimulated by basic student scholarships. We are aiming at 16 excellent candidates, in two calls, to fit within outgoing and incoming mobility schemes, and we are willing to offer them a competitive economic incentive for two years to do their research and eventually integrate, if they wish to do so, in the Andalusian Knowledge System. Relevance This program becomes relevant as a stimulus for attracting and retaining the best talent and as a contribution to the strengthening of the human potential in research and technology in Europe, and specifically in Andalusia.

Keywords: talentia,fellowships,experienced researchers,mobility,all areas of knowledge,academic excellence,human capital,innovation
How oxygen regulates the structure and function of microbial ecosystems (OXYGEN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Denmark,Denmark,Austria
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-04-01
End date: 2016-03-31
Duration (months): 60.0
Total project cost (EUR): 2568194.0
EU funding (EUR): 2568194.0
Participants: 3
Project status: CLOSED

Our project is called OXYGEN. Our aim is to develop and use cutting-edge high-sensitivity oxygen detection systems to explore how oxygen regulates the metabolism of aerobic and anaerobic organisms in experimental systems and in nature. We will explore and understand the complex structure of low oxygen ecosystems on the present Earth, and the evolution of these ecosystems through time in the face of changing concentrations of atmospheric oxygen.

Keywords: oxygen,evolution,sensor technology
The International Post doc Fellowship Programme in Plant Sciences (PLANT FELLOWS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2012-03-01
End date: 2016-08-31
Duration (months): 54.0
Total project cost (EUR): 11651402.88
EU funding (EUR): 4660561.15
Participants: 1
Project status: CLOSED

PLANT FELLOWS is a new international Post doc fellowship programme in the field of plant sciences. PLANT FELLOWS will be managed by the Zurich-Basel Plant Science Center, the sole beneficiary of the COFUND action, drawing from 10 years of expansion and success in fellowship management and higher educational establishments. PLANT FELLOWS will be open to applicants from all over the world. 15 European and 7 international universities and research institutes and 3 industry partners have been pre-defined as host organisations on the basis of their excellence in higher education and plant research. PLANT FELLOWS will offer 74 new Post doc fellowships spread between three different schemes (incoming, outgoing and reintegration) and a structured training programme for experienced researchers, including workshops, dedicated training in complementary skills and industrial placements. Unique in its kind, the fellows of the programme have the opportunity to obtain a Certificate in Plant Research and Development. PLANT FELLOWS thus aims at establishing a Training and Qualification Framework in the area of life-long learning/vocational training which complements the present postdoctoral training in plant sciences with an international competitive dimension. PLANT FELLOWS aims at delivering trained people who can enable the EU to respond to its changing needs in, for example, food production, plant-based energy production, sustainable land use, agricultural developments, and environment protection. By promoting a high level of intersectorial interactions and transnational mobility, the fellows will have access to frontiers expertise in plant research and state-of-the-art facilities in a way that is not possible within any existing or national programme. The mobility activities and adjustments to new cultures will contribute to building tolerance, confidence and loyalty - necessary attributes to meet global challenges.

Keywords: natural sciences,plant research,multidisciplinary,transnational,intersectorial,higher education training programme