Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Epigenomics and chromosome architecture one cell at a time (EpiScope)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1999780.0
EU funding (EUR): 1999780.0
Participants: 2
Project status: SIGNED

In Eukaryotes, cellular identity and tissue-specific functions are linked to the epigenetic landscape and the multi-scale architecture of the genome. The packing of DNA into nucleosomes at the ~100 bp scale and the organization of whole chromosomes into functional territories within the nucleus are well documented. At an intermediate scale, chromosomes are organised in megabase to sub-megabase structures called Topologically Associating Domains (TADs). Critically, TADs are highly correlated to patterns of epigenetic marks determining the transcriptional state of the genes they encompass. Until now, the lack of efficient technologies to map chromosome architecture and epigenetic marks at the single-cell level have limited our understanding of the molecular actors and mechanisms implicated in the establishment and maintenance of the multi-scale architecture of chromosomes and epigenetic states, and the interplay between this architecture and other nuclear functions such as transcription. The overall aim of EpiScope is to unveil the functional, multi-scale, 3D architecture of chromatin at the single-cell level while preserving cellular context, with a toolbox of groundbreaking high-performance microscopies (Hi-M). Hi-M will use unique combinations of multi-focus and single-molecule localization microscopies with novel DNA labeling methods and microfluidics. Hi-M will enable the study of structure-function relationships within TADs of different chromatin types and correlate single-cell variations in epigenomic patterns to 3D conformations with genomic specificity and at the nanoscale. Finally, Hi-M will be used to develop a novel high-throughput, high-content method to unveil the full pairwise distance distribution between thousands of genomic loci at the single cell level and at multiple length-scales. Our findings and technologies will shed new light into the mechanisms responsible for cellular memory, identity and differentiation.

Keywords: nuclear architecture,epigenomics,super resolution microscopy,fluorescence in situ hybridization,single cell,topologically associating domains,development,high throughput microscopy
Exploring the impacts of collaborative workspaces in rural and peripheral areas in the EU (Coral)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Germany,Germany,Austria,Austria,Greece,Greece,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3837030.48
EU funding (EUR): 3837030.48
Participants: 9
Project status: SIGNED

CORAL aims to unpack the latent dynamics and impacts of collaborative workspaces (CWS) in rural and peripheral areas and integrate them as development tools in local and regional policies to open up new potentials for socio-economic development. Whereas we have observed the rapid rise of CWS in urban agglomerations the past 15 years, there is now a gradual rise of CWS in rural and peripheral areas too. However, there is no clear evidence about their functions, impacts and the ways that policymaking should promote the rural CWS wave and assist in linking the development of CWS with processes of local socio-economic development. In fact, that policy link is much needed for those disadvantaged places (places that don’t matter) , as only a few EU policies (e.g. Interreg) have assisted, in a fragmented way, the development of CWS in peripheral and rural areas. At the same time, there is an urgent need for qualified professionals in academia and the policy arena, in order to effectively promote CWS in the lagging parts of the EU and by that, open up new development futures. CORAL envisages to provide specialized and tailor-made training to 15 young researchers to better understand and support the development processes of CWS in rural and peripheral areas, their wider impacts at the local and regional level, as well as at the level of the individual worker and the enterprise. Moreover, through different means of dissemination and exploitation (knowledge exchange days, CORAL schools, digital platform), the impacts of CORAL aim to reach a wider audience ranging from public policymakers to private stakeholders and CWS communities across the EU. The CORAL consortium consists of nine beneficiaries (five academic and four non-academic) and 6 partner organisations (four academic and two non-academic) from six EU Member States.

Keywords: collaborative spaces,coworking,creative hubs,rural,eu periphery
Trash-2-Cash: Designed high-value products from zero-value waste textiles and fibres via design driven technologies (Trash-2-Cash)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Materials for creative industries, including heritage
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Italy,Italy,Sweden,Finland,Türkiye,Sweden,Sweden,Slovenia,Netherlands,Denmark,United Kingdom
Call: Materials solutions for use in the creative industry sector (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-11-30
Duration (months): 42.0
Total project cost (EUR): 8890559.8
EU funding (EUR): 7933461.0
Participants: 21
Project status: CLOSED

Within Trash-2-Cash, growing problems with paper fibre waste from the paper industry and textile fibre waste, originating from a continuously increasing textile consumption, will be solved through design-driven innovation. This will be performed by using the wastes to regenerate fibres that will be included into fashion, interior and other products. The cotton production suffers from non-sustainable environmental and socio-economical issues and the polyester fibre manufacture produces waste that to date has no viable deposition. Designers will lead the recycling initiative, defining the material properties, and will feed the material scientists to evaluate newly developed eco-efficient cotton fibre regeneration and polyester recycling techniques. The future exploitation will be ascertained through a two-sided exchange between the designers and the end-product manufacturers, also taking into account the consumer-related product needs, and prototypes will be produced in a realistic test production environment. The objectives are to: • Integrate design, business and technology to a coherent discipline to establish new creative industries • Develop new material and product opportunities via creative design from waste or process by-product • Reduce the utilization of virgin materials; improve material efficiency; decrease landfill volumes and energy consumption • Use design for recycling with the vision of closing the material loop • Create new business opportunities by adding the return loop of the discarded goods to be reused into attractive products • Promote development of the creative sector by providing technological solutions for exploitation of waste streams Europe's creative industry will be strengthened through Trash-2-Cash taking the lead worldwide in the design for recycled materials area. Moreover, Trash-2-Cash will support a better waste utilization and contribute to reduction of landfill area needs.

Keywords: design,design driven technology,textile waste,paper fibre waste,cotton,polyester,cellulose fibres,textile fibres,dissolution,regeneration,recycling,fashion,consumer,sorting tech
HIGHER: “High performance Engine for Light Sport Aircraft (HIGHER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HIGHER project will launch on the aviation market an innovative engine which will contribute to make small aircrafts and helicopters individual, diffused, sustainable and safe transport vehicles. In order to reach this goal, the new engine conceived by Egimotors will ensure: - higher performance, thanks to the weight containment between 105 and 115 kg (20% lower than the average of the engines of the same power available today) coupled to an output of 200 hp and to a 4 valves-per-cylinder system that delivers high performance; - lower purchase cost, thanks to simple design, limited dimensions and weight, and multiple potential applications with consequent advantages in construction costs that allow a lower retail price; - lower operating costs, thanks to the possibility to use (in addition to AvGas) also MoGas (Automotive fuel) characterized by significantly lower cost. The study of thermodynamics matched to the geometry of the cylinder ducts was also designed to ensure a reduction of fuel consumption; - higher reliability and safety, thanks to high-quality construction component, technical processes choices and careful assembly. EGM 4x4 mechanical components are less stressed and consequently have longer service life. The electronic ignition and injection system, completely redundant and validated by extensive bench tests, also ensures high reliability; - lower environmental impact, thanks to in-depth study of the intake and exhaust gas system, which will be able to reduce fuel consumption and consequently pollution. In terms of business plan, the company strategy aims at selling in 5 years more then 500 engines, at a target price of 16,000 euro, with a turnover of about 3 millions per year since 2021 and a market share of 7%.

Keywords: innovative engine for light sport aircraft,low environmental impact,higher performance,aircraft,aviation
Ultimate connectivity platform for global IoT devices: boosting the competitiveness of IoT device makers (IoT4ALL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Estonia,Estonia
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2021-05-31
Duration (months): 36.0
Total project cost (EUR): 1983750.0
EU funding (EUR): 1388625.0
Participants: 2
Project status: CLOSED

For Europe, the Internet-of-Things (IoT) provides an opportunity to unlock 7 percentage points of GDP growth (€1 trillion) by 2025. The key role in achieving this potential is played by IoT device makers, who are exploring new global business models and are moving towards autonomous, self-learning, and fully automated services and products. However, these companies are facing significant connectivity challenges: 1. It is not technically possible to automatically manage connectivity traffic, cost and SIM cards on a global scale. 2. Available solutions are not compatible with a full range of wide-area connectivity technologies. 3. The data transfer prices for global connectivity (IoT devices located in different countries) are up to 500% higher compared to prices for local connectivity (all devices located in a single country). 4. The pricing schemes for global connectivity, including financial commitments, are rigid in adopting client’s use cases and are tailored for high-volume customers. We have developed a prototype of the IoT connectivity platform (www.1oT.mobi) that allows IoT device makers to get global data coverage for all of their devices. With the SME Instrument Phase 2 project we will deliver the solution that: 1. Is truly universal, able to serve more than 95% of IoT device makers that need wide-area coverage, irrespective of the connectivity technology used. 2. Unique easy-to-use self-service platform with a powerful Application Programming Interface (API), which enables the user to control, manage, and monitor SIM cards and their mobile data sessions around the world from one platform. 3. Offers global connectivity for at least 50% lower data costs. 4. Transparent pay-as-you-go pricing without volume commitments and termination fees. By 2023, at least 9.5 million SIMs of IoT device makers will be connected to 1oT platform. For us, the execution of commercialization strategy will result in annual revenues of €70 million (2023) and 101 jobs created
Promoting the internAtional competitiveness of European Remote Sensing companies through Cross-cluster collaboration (PARSEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Belgium,Serbia,Greece,Lithuania,Poland
Call: Cluster facilitated projects for new industrial value chains (H2020-INNOSUP-2018-01-two-stage, 2018)
Start date: 2019-05-01
End date: 2021-12-31
Duration (months): 32.0
Total project cost (EUR): 5294319.66
EU funding (EUR): 4800257.16
Participants: 10
Project status: CLOSED

Emerging industries, as high-potential growth sectors in early stage development, can be effectively supported by cross-sectoral cluster-facilitated innovation towards the creation of new value chains and the opening up of new markets. Earth Observation-derived information has been widely proven to improve productivity (e.g. reduced fertiliser, pesticide, water, labour inputs in precision agriculture), outputs (e.g. solar farm yield), and eco-friendliness (e.g. carbon footprint monitoring of industrial activities) in the emerging food, energy and environment industries. In designing, developing and delivering sustainable services that meet the needs of these industries, European SMEs need to be supported in accessing knowledge, capital, technology and markets. Recognising this need, PARSEC aspires to build a cross-sectoral/cross-border ecosystem whereby SMEs and innovative start-ups will gain: Access to knowledge (provision of a holistic portfolio of support services, including market, technology and investment training/ information as well as tailored coaching support); Access to technology (through three large scale demonstrators, acting as enablers for the development of new EO-based products/services); Access to capital (an innovative selection and funding scheme to ensure selection of high-potential ideas); Access to market (incl. cross-border and cross-sectoral matchmaking, investment readiness, export promotion). By providing access to these resources, PARSEC will concretely contribute to the establishment of new value chains bustling with innovative SMEs that can translate the large public investments in the Copernicus programme and numerous sector specific initiatives (related to food, water, energy, climate change, biodiversity, etc.) into applications and services meeting user needs and market demands, for the benefit of European economy and society.

Keywords: earth observation,access to capital,internationalisation support
PORTABLE SOLUTION FOR THE ELECTROCHEMICAL REGENERATION OF ACTIVATED CARBON (PORTABLECRAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Italy,Spain,Portugal
Call: Pilot lines based on more flexible and down-scaled high performance processing (H2020-SPIRE-2017, 2017)
Start date: 2017-10-01
End date: 2021-02-28
Duration (months): 41.0
Total project cost (EUR): 2883012.5
EU funding (EUR): 2206718.75
Participants: 8
Project status: CLOSED

Activated carbon is manufactured overseas (30% of production occurs in CHINA). As an example, in 2016, 12% of worldwide AC demand (0.23 million of tons) corresponded to Western Europe . A Europe import about 80% of their internal consumption of AC. PORTABLECRAC provides a successful business case to reduce overseas imports with negative competitive and environmental impacts in key industries in Europe. Furthermore, great exploitation and replication opportunities for circular-local economy development, at business and environmental perspectives, will be pursued and exploitation path assessed as key implementation task after feasibility analysis is completed. However, due to continuous use, EXHAUSTION of AC filters is a common issue with the consequent high cost in producing virgin filters again. Indeed, there is a side problem related to the manipulation and management of exhausted AC that has to be considered as highly contaminant waste and can vary at regional-national level. Accordingly, the viability of AC use at industrial level roots in the regeneration and reactivation of exhausted AC. AC can be regenerated (large facilities i.e. do it at this moment), reducing costs by about 50%. Regeneration of spent AC is mainly done by thermal regeneration (as is the case of EMIVASA). However, it requires off-site service, high energy input and carbon losses with negative environmental impacts against the solution provide by PORTABLECRAC as the key value proposition (Table 1) shows. PORTABLECRAC brings a sustainable and long term solution creating a direct and indirect employment in the “service-sector” from UE. PORTABLECRAC KEY VALUE PROPOSITION is to provide a solution to water treatment with 86% reduction in cost per kg/AC and 4 times reduction in CO2 emissions. Business model will be assessed and validated during the scope of the project, based on traditional key drivers for industry market penetration as cost reduction and legislation framework

Keywords: activated carbon,electrochemical regeneration,reactivation,portable technology,flexible maintenance,in situ,cost savings,co2 reduction
Embryonic stem cell origin of the adipose tissue macrophages (ESATM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Today insulin resistance (IR) is reaching pandemic proportions and it is predicted to emerge a leading worldwide morbidity by 2030. Immune cells, including the so-called adipose tissue macrophages (ATMs) have key roles in the development of this disease. Pharmacological intervention to shape ATM differentiation and function may be a straightforward approach to prevent or combat IR. However the stem cell origin of ATMs is still unclear, which blocks the development of such prevention or treatment strategies. Recent reports show that some specific sets of macrophages develop from embryonic hematopoietic stem cells (eHSCs) and not from the bone marrow as it was postulated before. Our preliminary studies raise the possibility that eHSCs are present in the mouse and the human adipose tissue and these stem cells replenish the ATMs in adulthood. The major scientific objectives of this project are to (a) address the critical question whether ATMs are derived from eHSCs, and (b) define whether the eHSC-derived ATMs can cause IR. These are novel and non-conventional ideas on the determination of IR and are challenging the current wisdom on ATM origin. The deliverables of this project may open a new path to alleviate or prevent IR through eHSCs.

Keywords: diabetes,insulin resistance,macrophage
Electro- and photochemical microreactors intensified by acoustics (MicroDisco)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1994500.0
EU funding (EUR): 1994500.0
Participants: 1
Project status: SIGNED

Small-scale flow reactors for electro- and photochemistry support the shift in chemical manufacture towards green and sustainable processes based on renewable energy sources. However, the industrial application of these small-scale flow reactors is significantly limited by their currently achieved throughput and productivity. The MICRODISCO project aims to overcome these productivity limitations by exploiting the synergistic effect of ultrasound on intensified electro- and photochemical reactors. Specifically, we will gain a fundamental understanding of the underlying ultrasound physics and their interplay with reactor geometry, material and fluid properties, based on beyond state-of-the-art modeling and experiments (Objective 1). Subsequently, we will exploit this fundamental understanding to controllably excite ultrasound resonance modes to overcome species and electron/photon transport limitations in rationally designed intensified reactors. We will eliminate the diffusion limitation of electrochemical reactors for high-throughput self-supported organic synthesis by inducing active mixing via ultrasound resonance (Objective 2). Furthermore, we will increase light utilization and mass transfer in two-phase photochemical reactors by inducing the gas-liquid atomization phenomenon (i.e. to nebulize liquid droplets from the liquid slug into the illuminated gas bubble) via ultrasound resonance (Objective 3). The MICRODISCO project will provide fundamental understanding of ultrasound resonance modes and a theoretical tool for their prediction, leading to innovative and intensified electro- and photochemical reactors promoting green and sustainable chemistry.

Keywords: microfluidics,ultrasound,flow chemistry,mass transfer