Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FUNctional GLASS (FUNGLASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,France,Portugal,Canada,Brazil
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2024-03-31
Duration (months): 63.0
Total project cost (EUR): 938400.0
EU funding (EUR): 864800.0
Participants: 5
Project status: SIGNED

The scientific objective of the project FUNGLASS- FUNctional GLASS integration in photonic devices and components- addresses one of the most crucial challenges in research and innovation which lies in the design and manufacturing of optical components and systems. Among the materials used in photonic devices, glasses play a central role: they are used as laser sources, lenses, smart screen, optical fibers and specialty fibers to name a few. FUNGLASS breakthrough relies on the control of nano/micro processing and 3D printing of glass by laser writing or poling, offering extraordinary opportunities for fabrication of elementary building-blocks such as multimaterial optical fibers with unique topology, morphology and novel properties for the design of integrated multifunctional components and devices. FUNGLASS proposes interdisciplinary European scale staff exchange programme with unique positioning on laser/field 3D nano/micro patterning and functionalizing of novel photonic glass materials allowing fabrication of sophisticated components and systems on their own. The involvement of large international centers with state of the art facilities for developing photonics components will enable provision of the required skills for developing a career in the private sector, as an entrepreneur, a CEO, a chief of R&D department etc. The involvement of international experienced and recognized professors, ER, involved in the project will also ensure that ESRs are prepared for a career in research excellence. Moreover, the strong lasting links between those centers allow the popup for an unpreceded international network in photonics and material. This proposal will contribute to sustain this network by the creation of joint unit laboratory between participants.

Keywords: glass,femtosecond laser processing,direct laser writing,fiber development,specialty fiber,hybrid materials for optic,optical sensors,mid ir technology
Demonstration of a disruptive rotor blade concept for large wind turbines (TRIBLADE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden,Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2020-05-31
Duration (months): 32.0
Total project cost (EUR): 2994044.5
EU funding (EUR): 2095831.15
Participants: 2
Project status: CLOSED

Wind energy is the fastest growing renewable energy source in Europe, accounting for 10.2% of total electricity in 2015, however there is still a need to reduce the overall cost of energy – CoE to increase its competitiveness. The capital costs represents 78% of CoE and can be broken down into several categories, with around 54% attributable to wind turbine, from which the blades represents 30%. CoE can be reduced by maximizing energy production for the site by installing larger turbines. However, as the length of current rotor blades increase, their associated cost and weight increase at a faster rate than the turbine’s power output. Furthermore, as blades get longer they are becoming increasingly more difficult to manufacture and transport setting the limit at 90m. Winfoor (WF) and Marstrom (MC) aim to pursue this market opportunity by bringing to market its innovative and ground-breaking blade technology – Triblade. Triblade is a “3-in-1” modular blade, built as a Composite Material Truss that will allow rotor blades to be longer (up to 50%), stiffer (up to 290%) and lighter (up to 78%), whilst reducing around 65.2% production costs and increasing ease of transport and installation resulting in up to 15.5% CoE reduction. These are game changing improvements that can play an important role in driving the development of next generation of larger turbines and accelerate the transition to greater use of renewables worldwide. TRIBLADE project is expected to significantly enhance WF&MC’s profitability, with expected accumulated revenue of €85M and profits of €40M, 6 years after commercialization. Moreover, the successful achievement of TRIBLADE objectives is expected to assist Europe in achieving objectives to secure a sustainable energy system based on a low-carbon electricity from wind. This project will therefore entail increased competitiveness for the SME value chain and for the EU as a whole.

Keywords: rotor blades,wind energy,large wind turbines,cost of energy,disruptive concept
Machine state forecasting technology coupled with product quality control to unleash productivity for the manufacturing sector (EnCORE) (EnCORE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Greece
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the manufacturing sectors, the traditional planned maintenance approach is no longer viable, as it cannot cope with the ever-rising complexity of production systems. This pressing problem hurts industry’s profitability, and unplanned downtime costs industrial manufacturers €43 billion per year. This pressing problem has fuelled the growth of the predictive maintenance market. Currently, predictive maintenance solutions employ typical machine learning approaches based on monolithic rule-based predictions and require from the customer labelled data that correspond to defective machine states. This impedes the penetration of predictive maintenance in the industry. EnCORE is the fruit of 5 years of R&D to develop proprietary deep neural networks fit for predictive maintenance applications. Our solution uses best-in-class deep learning technology removing the overheads related with data preparation and enable the prediction of machine’s future condition using data that correspond to normal machine states. This is a game changing approach in the predictive maintenance industry. EnCORE is at TRL-6, with our software being validated at two different applications, (1) a compression moulding machine that produces plastic bottle enclosures/caps and (2) a cold forming machine that produces razor blades. Our target market will be the Food & Beverage and Consumer Goods industries targeting both OEMs of machinery and End-Users use such machinery. To take our product to the market, we will employ an hybrid business model using both direct sales and sales through industrial IoT platforms. EnCORE’s unique offering unlocks tremendous value for our customers; this will fuel the adoption of our solution by the industry. In the commercialisation period, we forecast cumulative profits of about €15 million with a strong Return on Investment (ROI) of €13 million. This will allow us to grow our workforce by 83 new employees, to meet the expected market demand for our breakthrough product.
Insoles for Neuropathy and Balance Issues (Path Feel)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom,Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-12-31
Duration (months): 38.0
Total project cost (EUR): 3277000.0
EU funding (EUR): 2293900.0
Participants: 2
Project status: CLOSED

An aging population and diseases related to aging (Parkinson’s disease, diabetes, neuropathy) increase feet numbness, balance and mobility issues. Affected people stop feeling the ground properly, which makes them lose balance and increases the risk of falls and injuries, which in turn lead to devastating consequences. Patients and families lose their independence and public healthcare costs are rising as a result – now the European population aged 65+ uses 60% of healthcare resources. One of the ways to reduce the costs of care for the elderly and chronic patients relates to fall prevention. At Walk With Path we invented Path Feel – an insole that provides vibrational feedback to the feet in real time to help people feel the ground again. It increased the balance and mobility of 92% of users and reduces their risk of falls by 50%. We have proven that it works in number of pre-clinical studies. By bringing mobility back, Path Feel gives more freedom to the patient and the family. Within the project we will finish our existing prototype, validate it, certify, and introduce it to the market after the project ends. The elderly population in the EU is projected to increase, reaching 75 million in 2020 and 88 million in 2030. Over 220 million people worldwide suffer from balance and sensory issues, and the global walking aids market is estimated to surpass €1 billion by 2023, growing at an estimated CAGR of 4.3% from 2018 to 2023. We work with patient organizations and key opinion leaders to introduce the product to the market. We have multiple distribution agreements across the world (EU, Asia, America) and work with global shoe and insole manufacturers. We have already commercialized our first innovative product in the mobility sector – for patients with Parkinson’s disease.

Keywords: chronic diseases,preventative solutions,personalised medicine,unmet needs,neurological diseases,metabolic diseases,diabetes
Structure and function of repeat-derived non-coding RNAs in epigenetic regulation of mammalian pericentric heterochromatin (RNA-SHAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

A significant fraction of mammalian genomes is composed of repetitive elements, such as pericentric major satellite repeats. Repetitive elements present a critical challenge to genome stability because these regions are prone to recombination. To safeguard genome integrity, these repetitive sequences are maintained in an epigenetically silent heterochromatic state to prevent mutagenic recombination. A confounding enigma revealed by recent transcriptome-wide studies is that repetitive elements are actively transcribed into noncoding RNAs (ncRNAs). Furthermore, these repeat-derived transcripts are themselves important to maintain the heterochromatic structure at repetitive elements. Nevertheless, it appears that a certain balance must be achieved since overexpression of repeat-derived ncRNAs is a hallmark of the most common types of cancer. How repeat-derived ncRNAs function in epigenetic regulation of heterochromatin is poorly understood. In this proposed study, ncRNAs transcribed from mouse pericentric major satellite repeats will be investigated as a paradigm to understand the precise mechanism of how these ncRNAs regulate heterochromatin formation. The key element of the proposed study is characterizing the function of major satellite RNAs from a structural perspective. This is a novel and promising approach because the functions of RNA molecules are intimately linked with their ability to fold into complex structures. A possible scenario is that accurate folding of major satellite RNA directs the local recruitment of chromatin complexes to pericentric loci. To address this hypothesis, the proposed research programme aims to achieve the following: (i) determine the structure of major satellite RNAs; (ii) determine if major satellite RNAs are divided into functional domains and how this relates to the structure; and (iii) determine how the structure of major satellite RNAs influence their interaction with pericentric DNA and chromatin-associated proteins.

Keywords: noncoding rna,rna structure,rna protein complexes,heterochromatin,pericentric heterochromatin,repetitive elements
European Banking Union and Current Account Imbalances (EBUCAI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Financial liberalization and cross-border banking underpin a striking global trend: while creditor countries had net financial claims on debtors of 20% of GDP in 1980, by 2010 this had risen to 70%. In accounting terms, such international wealth re-distribution materializes via current account (CA) surpluses by creditors and deficits by debtors. Hence the interest in what drives such CA imbalances, their desirability, and sustainability. The recent Eurozone crisis brought further attention to the issue: Greece, Ireland, Portugal, and Spain all had unprecedented CA deficits in the run up to the crisis, and studies indicate that such high deficits helped trigger it. The MAIN OBJECTIVE of this project is to deepen understanding of the links between CA imbalances, cross-border banking and credit. Much of CA flows consist of purchase/sale of debt contracts between residents and foreigners, and since up to two thirds go through banks, the accounting link is clear. Unclear is the behavioral link: What motivates such flows and makes them very risky at times? This project’s novelty is to build a model of this behavioral link, focusing on the Eurozone. This main objective WILL BE ACHIEVED BY: - A new general equilibrium model featuring international risk-taking banks with potential externalities on the economy and which can amplify CA imbalances - A new database on banking indicators and macro-determinants of CAs - Model estimates using O2 and state-of-the-art empirical methods - Assessment of risk thresholds and welfare of regulatory policies - Scenarios for intra-Eurozone imbalances under the EU banking union This research is HIGHLY RELEVANT TO THE WORK PROGRAM because unexplained CAs expose countries to undetected risks, and studies on Eurozone CAs do not model bank behavior thus overlooking a main component of imbalances. This research is timely because growing cross-border banking affects imbalances and understanding such links is key to EU banking union policies.

Keywords: current account imbalances,financial sector linkages,banking union
Addressing Global Challenges through International Scientific Consortia (INSCONS); Case studies in biomedicine, the geosciences, and nuclear fusion research (INSCONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2026-02-28
Duration (months): 78.0
Total project cost (EUR): 1997021.0
EU funding (EUR): 757452.25
Participants: 2
Project status: SIGNED

INSCONS is a groundbreaking, large-scale examination of the organisational dynamics of international scientific consortia (ISCs) and the interactions of these consortia with broader scientific communities, national bureaucracies, and industry. ISCs are very complex organisations with work being carried out at geographically dispersed sites, and involving international stakeholder groups from across the realms of science, policy, and industry. As these ISCs are becoming more important in efforts to address global challenges in areas such as health, the environment, and clean energy, our understanding of the distinctive organizational dynamics governing these consortia has lagged behind. Accordingly, there is a pressing need for novel organisational theory and frameworks that will advance our understanding of ISCs. INSCONS is an ambitious effort to address this need, using a comparative, interdisciplinary approach. Three case studies of large, international ISCs in nuclear fusion research, biomedicine, and the geosciences are at the core of INSCONS. The INSCONS project will examine four aspects of these ISCs. It will 1) Map the internal organisational dynamics of ISCs using interviews, bibliometric network analyses, and ethnographic field studies on everyday work in ISCs. 2) It will study ISCs’ interactions with the broader scientific community by conducting a survey among researchers in the scholarly fields ISCs operate in, and by analysing these fields’ co-authorship networks. 3) It will examine the (inter)national political processes and bureaucratic wrangling shaping ISCs. 4) It will examine relationships of dependency and influence between ISCs and industry through case studies as well as analyses of patenting and publication activities. Taken together, the project outputs of INSCONS will bring into clear focus the sociology and politics, as well as the operational complexities that govern this important, new organisational form in contemporary science.
MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response (MICROB-PREDICT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Germany,Germany,Switzerland,Belgium,Norway,Belgium,Hungary,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark
Call: Exploiting research outcomes and application potential of the human microbiome for personalised prediction, prevention and treatment of disease (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2025-03-31
Duration (months): 75.0
Total project cost (EUR): 15000002.5
EU funding (EUR): 15000000.0
Participants: 24
Project status: SIGNED

Decompensation of liver cirrhosis and progression towards acute-on-chronic liver failure (ACLF) causes 1.2 million deaths/year. Microbiome is causally involved in cirrhosis progression and is for drugs the first interaction point with the patients. Drugs can alter the microbiome leading to unwanted effects or even facilitating their effects, but the microbiome metabolizes the drugs, shapes their effects and possibly determines the host response to drugs. As each person carries an individual microbiome, insight in these processes should help stratify or even personalize patient health care and treatment. The aims of MICROB-PREDICT are 1) to better understand the role of microbiome and the gut-liver-axis interactome with respect to microbiome functionalities, 2) to identify and validate microbiome-based biomarkers and signatures for personalized prediction of decompensation and ACLF, and response to treatment, 3) to design three new tests as easy-to-use tools and point-of-care, smartphone-connected nanobiosensors, and 4) to validate them in a randomized controlled trial. MICROB-PREDICT will assemble existing data and samples from major microbiome initiatives in hepatology (12 international studies, >10,000 patients), and enrich them with holistic and in-depth analysis using cutting-edge multi-omics technologies of host and microbiome from different body sites in samples of >1,000 patients collected in a longitudinal manner with sequential visits and controlling for confounders. MICROB-PREDICT results will foster more accurate, personalized risk stratification and significant steps towards personalized treatment of decompensated cirrhosis and ACLF. World-leading microbiome specialists, technology leaders and clinical experts make this a programme of scientific excellence; patient organisations (ELPA) and the European Association for the study of the Liver (EASL) will channel our results into a powerful dissemination, communication and exploitation programme.

Keywords: microbiome,host,nanobiosensors,signatures,biomarker,acute on chronic liver failure,cirrhosis,multi omics,response to treatment,theranostics
Beyond the Iron Curtain (BYONIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2024-05-31
Duration (months): 84.0
Total project cost (EUR): 1668418.0
EU funding (EUR): 1668418.0
Participants: 1
Project status: SIGNED

As one of the largest carbon reservoirs in the Earth system, the ocean is central to understanding past, present and future fluctuations in atmospheric carbon dioxide. In this context, microscopic plants called phytoplankton are key as they consume carbon dioxide during photosynthesis and transfer part of this carbon to the ocean’s interior and ultimately the lithosphere. The overall abundance of phytoplankton also forms the foundation of ocean food webs and drives the richness of marine fisheries. It is key that we understand drivers of variations in phytoplankton growth, so we can explain changes in ocean productivity and the global carbon cycle, as well as project future trends with confidence. The numerical models we rely on for these tasks are prevented from doing so at present, however, due to a major theoretical gap concerning the role of trace metals in shaping phytoplankton growth in the ocean. This omission is particularly lacking at regional scales, where subtle interactions can lead to their co-limitation of biological activity. While we have long known that trace metals are fundamentally important to the photosynthesis and respiration of phytoplankton, it is only very recently that the necessary large-scale oceanic datasets required by numerical models have become available. I am leading such efforts with the trace metal iron, but we urgently need to expand our approach to other essential trace metals such as cobalt, copper, manganese and zinc. This project will combine knowledge of biological requirement for trace metals with these newly emerging datasets to move ‘beyond the iron curtain’ and develop the first ever complete numerical model of resource limitation of phytoplankton growth, accounting for co-limiting interactions. Via a progressive combination of data synthesis and state of the art modelling, I will deliver a step-change into how we think resource availability controls life in the ocean.