Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INnovative Actuation Concepts for Engine/Pylon/Wing Separation FLOw Control (Design, Build and Wind Tunnel Test) (INAFLOWT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Israel,Russian Federation,Czechia
Call: Design, Build and Test Innovative Actuation Concepts for Separation Flow Control (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-06-01
End date: 2020-09-30
Duration (months): 40.0
Total project cost (EUR): 1146750.0
EU funding (EUR): 700000.0
Participants: 5
Project status: CLOSED

The objective of the INAFLOWT project is to use combinations of existing active flow control (AFC) concepts to generate a major advance in AFC aerodynamic efficiency and reliability. Steady suction in combination with oscillatory blowing will be combined using arrays of the no-moving parts SaOB actuator. Active boundary layer separation control concepts will be studied using numerical simulations, as well as with bench-top, simplified geometry and small scale wind tunnel testing. The most promising concept will be tested, integrated as real-scale prototypes in a large wind tunnel model representative of the ultra-high bypass ratio (UHBR) engine/pylon/wing/high-lift system configuration, already tested within AFLONEXT, at realistic Reynolds number, to prove results in near industrial environment. The INAFLOWT consortium consist of known experts with vast experience and extensive excellence record of collaborations in the areas of AFC, high-lift aerodynamic, wind tunnel testing and CFD simulations. These capabilities and features will guarantee the successful realization of the ambitious goals of the INAFLOWT project and will progress the proposed AFC configuration beyond the State-of-the-Art. The outputs are ambitious and innovative and will pave the way to operational use of UHBR engines in commercial aircraft which will provide significant operational benefits of future European aviation products.

Keywords: active flow control,wing engine integration,high lift system,separation control,boundary layer,actuators,suction,pulsed blowing
Sequence and structural requirements for Y RNA cleavage (YRNAcleave)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Small non-coding RNAs play important roles in gene expression regulation. Initially the attention was focused on the 21-24-nucleotide small RNAs such as microRNAs but later on deeper sequencing experiments using next generation sequencing revealed a slightly longer class of small RNAs that are 30-34 nucleotides long. These longer small RNAs are often generated from known non-coding RNAs such as tRNA or snoRNA. The biogenesis of these longer small RNAs seems to be diverse and is not well understood. The host laboratory have characterised the biogenesis of such longer small RNAs generated from Y RNAs in mammalian cells and found that it is different from microRNA biogenesis but also from the way tRNA derived small RNAs are produced. Results from a high-throughput mutagenesis approach suggest that the secondary structure of the Y RNA, rather than its sequence, determines where the cleavage happens that liberates the small RNAs from the 3' end of Y RNAs. This project aims validating these results and also to apply a high-throughput mutagensis screen on the 5' region of the Y RNA to study the production of small RNAs from that end of the molecule. Combining the results for Y RNA derived longer small RNA generation from both 5' and 3' end of these molecules will enable the experienced researcher to establish how this class of small RNAs are produced by designing specific novel mutants and test them in mammalian cells. Another aim of the project is to give training to the experienced researcher in mammalian cell biology and bioinformatics to add his existing molecular biology and microbiology skills.

Keywords: y rnas,small non coding rnas,gene expression regulation
Topological Superconductivity in Graphene (SUPERGRAPH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 2044178.0
EU funding (EUR): 2044178.0
Participants: 1
Project status: SIGNED

In recent years, a considerable stream of work from the condensed matter community has been focusing on hybrid systems coupling superconductors to various topological states of matter. Such a heterogeneous coupling is pivotal in enabling the emergence of new excitations –the Majorana or parafermion— that could be used as quantum bits (qubits) with unique properties of non-locality and immunity to external perturbations, essential to encode and manipulate quantum information in a robust and stable fashion. Nevertheless, topological insulators that can be efficiently hybridized with superconductors and enable reliable coherent manipulation are still missing. This project aims at demonstrating a new topological insulator, the quantum Hall topological insulator that emerges in graphene as an unusual quantum spin Hall phase, as the ideal platform for topological superconductivity. Its novelty hinges on an unprecedented substrate engineering that profoundly modifies the quantum Hall ground state of neutral graphene. The ensuing robust quantum Hall phase harbors spin-filtered, helical edge states that can be easily coupled to superconducting electrodes for investigating novel hybrid superconducting quantum circuits. The versatility of graphene enables designing locally gated quantum devices, tunnelling experiments, and coupling to a photon cavity for time-resolved spectroscopy to unveil Majoranas or parafermions in unprecedented fashion. Ultimately, quantum coherent manipulation of Majorana qubits in hybrid devices will be performed, providing a major breakthrough in the way of fault-tolerant quantum computers. Moreover, the identification of parafermions will constitute a considerable conceptual advance that will open a totally new horizon for topological superconductivity and quantum computing technologies.

Keywords: graphene quantum hall effect,topological superconductivity
MAGIC (MAnufacturing of Gene delivery tools for Industrial and Clinical applications) (LentiFactory)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Founded in 2005, Vectalys is a biotech company that develops world leading gene delivery technologies for industrial and therapeutic applications. Vectalys has built a state-of-the-art proprietary lentiviral vectors (LV) production platform to provide its customers and partners with the highest quality of LV. Based on 10 years of collaborative research, the resulting LV purity is now recognized as a key success factor for cutting-edge stable cell engineering on primary and stem cells. In parallel, thanks to its deep understanding of market needs, Vectalys has developed and patented a game-changing class of RNA carriers called LentiFlash (LF), a new generation of non-integrating LV dedicated to gene-editing applications requiring a transient expression. Bioprocessing know-how, stable and transient delivery tools and intellectual property combine into a unique and powerful integrated platform capable of accelerating both gene-editing and immunotherapy applications. Based on recent results of early CAR-T cells clinical trials, mainly in the US, the market will now need an extensive scale-up capacity to produce GMP-grade LV and LF. The application potential is significant and includes both clinical approaches (gene therapy, gene-editing, and immunotherapy) and industrial systems (synthetic biology, modelling development). Compared to the US, there is in Europe a clear lack of clinical manufacturing infrastructure and of integrated platforms that include both research and GMP production, thereby offering a broad expertise from vector design to therapeutic strategies. From a non-regulatory pre-clinical stage market, Vectalys has the capacity to move forward into the clinical stage market as a GMP grade value provider. The company has taken the technological lead in this field in Europe and is now committed to producing these tools at a clinical grade in order to transform the lives of patients with severe genetic and rare diseases as well as untreated cancers.

Keywords: lentiviral vector,non integrating,gmp grade,cells transduction,gene delivery,transient expression,gene therapy,rna delivery,high quality,high purity
ATOMic Insight Cavity Array Reactor (ATOMICAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1496000.0
EU funding (EUR): 1496000.0
Participants: 1
Project status: CLOSED

The goal of ATOMICAR is to achieve the ultimate sensitivity limit in heterogeneous catalysis: Quantitative measurement of chemical turnover on a single catalytic nanoparticle. Most heterogeneous catalysis occurs on metal nanoparticle in the size range of 3 nm - 10 nm. Model studies have established that there is often a strong coupling between nanoparticle size & shape - and catalytic activity. The strong structure-activity coupling renders it probable that “super-active” nanoparticles exist. However, since there is no way to measure catalytic activity of less than ca 1 million nanoparticles at a time, any super-activity will always be hidden by “ensemble smearing” since one million nanoparticles of exactly identical size and shape cannot be made. The state-of-the-art in catalysis benchmarking is microfabricated flow reactors with mass-spectrometric detection, but the sensitivity of this approach cannot be incrementally improved by six orders of magnitude. This calls for a new measurement paradigm where the activity of a single nanoparticle can be benchmarked – the ultimate limit for catalytic measurement. A tiny batch reactor is the solution, but there are three key problems: How to seal it; how to track catalytic turnover inside it; and how to see the nanoparticle inside it? Graphene solves all three problems: A microfabricated cavity with a thin SixNy bottom window, a single catalytic nanoparticle inside, and a graphene seal forms a gas tight batch reactor since graphene has zero gas permeability. Catalysis is then tracked as an internal pressure change via the stress & deflection of the graphene seal. Crucially, the electron-transparency of graphene and SixNy enables subsequent transmission electron microscope access with atomic resolution so that active nanoparticles can be studied in full detail. ATOMICAR will re-define the experimental limits of catalyst benchmarking and lift the field of basic catalysis research into the single-nanoparticle age.

Keywords: single nanoparticle,microcavity,cavity reactor,batch reactor,array reactor,graphene,ultra sensitive,ambient pressure tem,structure activity relation,super activity,super active nanoparticles
NETCO-PD: 14 experienced researchers in network science for Europe (NETCO-PD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2059680.0
EU funding (EUR): 1029840.0
Participants: 1
Project status: SIGNED

Networks for communication, transportation, finance and energy form the backbone of modern society. Reliable and efficient network infrastructures are of enormous economic and social value, and their importance will only increase in the coming years. Highly skilled researchers familiar with networks are therefore urgently needed. They should have a deep understanding of methods to optimize network performance, to control processes running on networks, and to predict how these processes will evolve over time. NETCO-PD will train 14 such researchers at the postdoctoral level, who will gain the necessary scientific knowledge and professional skills for a successful career inside and outside academia. The duration of the program is 60 months. In the first year, two calls will be opened to appoint 14 ERs, for 24 months each. The main objectives of NETCO-PD are: • To provide Europe with 14 future research leaders in the important area of complex networks, where there is great demand for highly skilled researchers. • To bring together expertise from two disciplines, stochastics (a subarea of mathematics) and algorithmics (a subarea of computer science), and to train ERs by performing world-class research in these disciplines and at their interface. This unique interdisciplinary approach is essential for dealing with complex network problems, since the performance of network algorithms is influenced by the highly volatile nature of network processes, and vice versa. • To attract talented and creative junior researchers at the postdoctoral level, offer them attractive working conditions in 2-year contracts, as well as the best possible training and career perspective. • To extend the NETWORKS training program with activities targeted to postdoctoral researchers. This extension fills a gap in the training of young researchers at a crucial stage in their career, and cannot be acquired anywhere else in The Netherlands.

Keywords: networks science,large scale networks,stochastics,algorithmics
Developing Innovative Market Orientated Prediction Toolbox to Strengthen the Economic Sustainability and Competitiveness of European Seafood on Local and Global markets (PrimeFish)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Iceland,Italy,Italy,Germany,Spain,Norway,Norway,France,France,Denmark,United Kingdom,Canada,Viet Nam,Faroe Islands
Call: Consolidating the economic sustainability and competitiveness of European fisheries and aquaculture sectors to reap the potential of seafood markets (H2020-BG-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 5275426.25
EU funding (EUR): 4997912.5
Participants: 16
Project status: CLOSED

The overall aim of PrimeFish is to improve the economic sustainability of European fisheries and aquaculture sectors. PrimeFish will gather data from individual production companies, industry and sales organisations, consumers and public sources. The data will be related to the competitiveness and economic performance of companies in the sector; this includes data on price development, supply chain relations, markets, consumer behaviour and successful product innovation. The large industry reference group will facilitate access to data on specific case studies. A data repository will be created, and PrimeFish will join the H2020 Open Research Data Pilot to ensure future open access to the data. The effectiveness of demand stimulation through health, label and certification claims will be evaluated and compared with actual consumer behaviour. PrimeFish will assess the non-market value associated with aquaculture and captured fisheries as well as the effectiveness of regulatory systems and thereby provide the basis for improved societal decision making in the future. The collected data will be used to verify models and develop prediction algorithms that will be implemented into a computerized decision support system (PrimeDSS). The PrimeDSS, together with the underlying data, models, algorithms, assumptions and accompanying user instructions will form the PrimeFish Decision Support Framework (PrimeDSF). The lead users, typically fishermen, aquaculture producers and production companies, will be able to use the PrimeDSF to improve understanding of the functioning of their markets and in setting strategic plans for future production and innovation which in turn will strengthen the long term viability of the European fisheries and aquaculture sectors. This will also benefit consumers, leading to more diversified European seafood products, enhanced added value, novel products and improved information on origin, certification and health claims.

Keywords: competitiveness,economic performance,supply chain,supply and demand,decision support systems,consumer behaviour and preferences,market trends,labels and health claims,successful novel fish products
Innovative technologies and concepts for fine particle flotation: unlocking future fine-grained deposits and Critical Raw Materials resources for the EU (FineFuture)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Italy,Ukraine,Germany,Spain,Germany,Türkiye,Bulgaria,Greece,Greece,Poland,Poland,Belgium,France,France,France,United Kingdom,United Kingdom
Call: New solutions for the sustainable production of raw materials (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 6195022.5
EU funding (EUR): 6195022.5
Participants: 17
Project status: SIGNED

Froth flotation is arguably the most important mineral separation technique. By making use of differences in surface properties between minerals, valuable particles are concentrated in large tanks by attaching to bubbles, which form a froth phase that overflows as a mineral-rich concentrate. However, current flotation technologies do not work adequately for fine particles, below 20 µm in size. This is a serious challenge at present limiting the exploitation of deposits and proper recycling of end of life products containing Critical Raw Materials (CRM). This FineFuture project will advance the fundamental understanding of fine particle flotation phenomena, which will lead to the development of ground-breaking technological solutions. This will not only help unlock new CRM deposits but also contribute to increase the resource and energy efficiency of current operations where the fines are lost to tailings. FineFuture will also enable proper reprocessing of old tailings deposits and be technology-transferred to other raw material particle-based processes within the circular economy, thus leading the way in the sustainable use of resources. For the EU industry the ability to float fine particles will be fundamental in securing access to raw materials in the future, yet to date there is no large scale collaborative effort to achieve this. The FineFuture consortium brings together an industry- and user-driven multidisciplinary team with the skills and experience required to tackle the challenging objectives set up for this project. Through a first of its kind research approach, the consortium’s combined expertise in science, engineering and industrial practice will allow a robust and knowledge-based development of innovative fine particle flotation technologies. This project will thus help boosting EU technologies for sustainable raw material processing in Europe and abroad, contributing to energy- and resource-efficient processing in benefit of the future generations.

Keywords: froth flotation,fine particle flotation
Reshaping Attention and Inclusion Strategies for Distinctively vulnerable people among the forcibly displaced (RAISD)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Hungary,Türkiye,Finland,Jordan,Lebanon
Call: Addressing the challenge of forced displacement (H2020-SC6-MIGRATION-2018, 2018)
Start date: 2019-02-01
End date: 2022-06-30
Duration (months): 41.0
Total project cost (EUR): 2662129.08
EU funding (EUR): 2662128.0
Participants: 8
Project status: CLOSED

Forced displacement crises overcome societies and institutions all over the world. Pushed by the urgencies rather than events, solutions are frequently reactive, partial, and disregard some groups. The project ‘Reshaping Attention and Inclusion Strategies for Distinctively vulnerable people among the forcibly displaced’ (RAISD) aims at identifying highly Vulnerable Groups (VG) among these forcibly displaced people, analysing their specific needs, and finding suitable practices to address them. The concept of ‘vulnerability context’ considers the interplay between the features of these persons and their hosting communities, their interactions and experiences, and how different solutions for attention and inclusion affect them. As a result of this work, a methodology to carry out these studies will be developed. These goals are aligned with the call. They pursue characterizing these migrations and developing suitable aid strategies for them. The Responsible Research and Innovation (RRI) frames the project. It proposes that all actors (including civil society) co-design actions, transversely integrates the gender perspective, and supports sustainability. Our research strategy will be based on methodological triangulation (i.e. the combined application of several methodologies). We will implement it through a specific participatory action research approach to fulfil the aim of undertaking advocacy-focused research, grounded in human rights and socio-ecological models. The team will work as a network of units in countries along migration routes. The units will promote the VG people’ involvement, so they can speak with their own voices, gather information, and test practices. Work will rely on a tight integration of Social and Computer Sciences research. Automated learning and data mining will help to provide evidence-based recommendations, reducing a priori biases. A software tool will support collaboration, continuing previous H2020-funded RRI work.

Keywords: inclusion strategy,vulnerable group,displaced people,vulnerability context,personalisation,community adapted,action research unit,methodology,data gathering,data mining,collaborative sw