Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies (V.A. Cure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Germany,Germany,Belgium,Finland,Finland,Sweden,Sweden,Belgium,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-03-01
End date: 2023-02-28
Duration (months): 48.0
Total project cost (EUR): 3792135.6
EU funding (EUR): 3792135.6
Participants: 18
Project status: SIGNED

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs. V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases. The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

Keywords: vascular development,vascular anomalies,genetics,imaging,animal models,cellular models,next generation sequencing,molecular therapy,somatic mutation,repurposing of drugs
Sustainable and Cost Efficient High Performance Composite Structures demanding Temperature and Fire Resistance (SuCoHS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Switzerland,Belgium,Switzerland,Belgium,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Maintaining industrial leadership in aeronautics (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 6638938.74
EU funding (EUR): 6638938.74
Participants: 16
Project status: CLOSED

In order to maintain the leadership of the European aeronautics, the SuCoHS project will investigate potential weight and cost savings in expanding the use of composite materials in areas of demanding high thermal conditions (high temperature and fire). In particular, this project envisages new structural concepts with novel multi-material composites to provide high resistivity against thermal, mechanical and fire loading. These developments also cater for high production rates, providing a cost competitive manufacturing process at minimum material and energy consumption, while reducing the requirement for visual inspection or rework. New solutions for structural health monitoring are considered within the structures to enable condition-based maintenance taking into account actual loading and structural conditions. Instead of an isolated investigation of innovative technologies the project will develop an integrated framework for the adaption of these promising technologies to different aeronautic components to increase efficiency during design, manufacturing and operation. Three industrial use cases are defined from real industrial design challenges to set requirements, to validate new technologies and to demonstrate technical feasibility near to operation environment: a high temperature resistance nacelle component, a composite aircraft interior shell and a tail cone panel substructure. The SuCoHS project gathers 14 partners from 7 European countries, amongst which 2 technical universities, 3 research centers, 4 SMEs and 8 large companies. The requested EU funding amounts to 6 638 944 Euros for a 3-year project duration.

Keywords: high temperature and fire resistant composite structure,multiphysical and multidisciplinary analysis,structural health monitoring,maintenance scheduling,industry 4 0
General theory for Big Bayes (GTBB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 2176702.0
EU funding (EUR): 2176702.0
Participants: 1
Project status: SIGNED

In the modern era of complex and large data sets, there is stringent need for flexible, sound and scalable inferential methods to analyse them. Bayesian approaches have been increasingly used in statistics and machine learning and in all sorts of applications such as biostatistics, astrophysics, social science etc. Major advantages of Bayesian approaches are: their ability to model complex models in a hierarchical way, their coherency and ability to deliver not only point estimators but also measures of uncertainty from the posterior distribution which is a probability distribution on the parameter space at the core of all Bayesian inference. The increasing complexity of the data sets raise huge challenges for Bayesian approaches: theoretical and computational. The aim of this project is to develop a general theory for the analysis of Bayesian methods in complex and high (or infinite) dimensional models which will cover not only fine understanding of the posterior distributions but also an analysis of the output of the algorithms used to implement the approaches. The main objectives of the project are (briefly): 1. Asymptotic analysis of the posterior distribution of complex high dimensional models 2. Interactions between the asymptotic theory of high dimensional posterior distributions and computational complexity. We will also enrich these theoretical developments by 3 strongly related domains of applications, namely neuroscience, terrorism and crimes and ecology.

Keywords: bayesian nonparametrics,high dimensional models,complex models,asymptotic theory
Data-protection toolkit reducing risks in hospitals and care centers (ProTego)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Israel,Belgium,Belgium,France,United Kingdom,United Kingdom
Call: Toolkit for assessing and reducing cyber risks in hospitals and care centres to protect privacy/data/infrastructures (H2020-SC1-FA-DTS-2018-1, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 4457722.5
EU funding (EUR): 4457722.5
Participants: 14
Project status: CLOSED

Health care is an essential service that uses a great deal of sensitive personal data which has a high black market value being a lucrative target for data theft and ransomware attacks.The EU NIS Directive (EU 2016/1148) and GDPR (EU 2016/679) will harmonize and improve information security in Europe. Both require relevant ICT infrastructure operators to perform risk assessments, introduce appropriate security measures to manage identified risks, and report security breaches. Unfortunately, risk-based approaches are notoriously difficult to implement in a consistent and comprehensive fashion. They depend on a high level of understanding of both cybersecurity and of the system or network to be protected, are labour intensive and costly and typically done by small teams. This is increasingly inappropriate as health care providers introduce IoT systems, cloud services and (in the near future) 5G networks to provide services in which patients are more engaged, may own some of the devices used, and want access in hospitals, on the move or at home. The ProTego project will develop a toolkit and guidelines to help health care systems users address cybersecurity risks in this new environment by introducing 3 main advances over current approaches: Extensive use of machine intelligence: a combination of machine inference exploiting a priory knowledge for security-by-design, and machine learning from data for run-time threat detection and diagnosis; Advanced data protection measures: advanced encryption techniques and hardware based full memory encryption, and multi-stakeholder IAM to control access to and by user devices, to protect data at rest and provide ultra-secure data exchange portals; Innovative protocols for stakeholder education: using security-by-design analysis to target training and support stakeholders to contribute to networok overall security.The toolkit will be integrated and validated in IoT and BYOD-based case studies at two hospitals.

Keywords: cybersecurity toolkit,iot remote care,byod ephi protection
JPIAMR- ANTIMICROBIAL TRANSMISSION INTERVENTIONS (JPIAMR-ACTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: ERA-NET Cofund
Partnership: JPIAMR-ACTION (ERA-NET)
Countries involved: Estonia,Germany,Spain,Ireland,Ireland,Italy,Israel,Germany,Italy,Argentina,Norway,Finland,Hungary,Lithuania,Poland,Moldova, Republic of,Belgium,Sweden,Latvia,France,Netherlands,Denmark,Canada,United Kingdom
Call: ERA-NET to support the Joint Programming Initiative on Antimicrobial resistance (JPIAMR) (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 26311250.0
EU funding (EUR): 8151412.5
Participants: 26
Project status: SIGNED

In the past 90 years since their discovery, antibiotics have saved millions of lives from bacterial diseases. However, emerging resistance to antimicrobials now threatens many advances achieved in modern medicine. AMR is a critical global health issue tightly linked with the One Health concept, which recognises that human and animal health are inextricably linked, and that diseases are transmitted from humans to animals and vice versa. One Health also encompasses the environment as another link between humans and animals and a potential source and reservoir of AMR. Antimicrobial resistance is a growing global health concern and threatens the future treatment and health of humans and animals. In addition, AMR limits our ability to achieve several of the UN Sustainable Development Goals (SDGs). The global challenge to address AMR goes beyond the production of new antibiotics and therapies. Reducing demand for new antibiotics through public awareness, infection prevention and control, prudent and rational use of antibiotics for humans and animals, as well as effective diagnosis and surveillance of antibiotic-resistant infections and monitoring antibiotic use, are crucial when dealing with this problem globally. The transmission and spread of AMR in and between One Health compartments is complex, which emphasises the need for comprehensive interventions to reverse the trend of increasing human and animal infections resistant to treatment. The ERA-NET Cofund JPIAMR-ACTION will tackle this central challenge by supporting research and innovation for the development and testing of strategies and methodologies to reduce the transmission and spread of AMR within a full One Health spectrum. The JPIAMR-ACTION co-funded call and other activities will be instrumental in producing new innovative approaches, and advancing existing actions towards the development of new and improved interventions to inhibit or limit the development of AMR in humans, animals and the environment.

Keywords: antimicrobial resistance,transmission,interventions,infection
Are non-nutritive sweeteners vascular-safe substitutes for added sugars? (SWEETENED HEARTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

In an effort to reduce the incidence of obesity, type 2 diabetes and cardiovascular disease, leading health agencies around the world are currently promoting the consumption of food and beverages containing non-nutritive sweeteners (NNS), advocating them as healthy alternatives to products sweetened with added sugars. As the harmful health effects of excess sugar consumption are often attributed to the high-energy content of added sugar, it has been assumed that NNS are physiologically inactive simply because they have little to no energy content. Recent evidence, however, demonstrates an increased risk in total and cardiovascular disease mortality in people consuming at least two NNS-sweetened beverages per day. While these findings are interesting, they are difficult to interpret as NNS are typically consumed more often by those whose cardiometabolic health is already compromised. Despite this, evidence from animal studies, including that delivered by our own consortium, indicate that NNS have the potential to disrupt normal metabolic and vascular function, events that are primary in the development of obesity, insulin resistance and cardiovascular disease. Indeed, rather than benefiting us, the impact of consuming NNS may be as bad on human health as the effects of excess sugar consumption. To bridge the findings from epidemiological and experimental research, this Standard EF will, for the first time in vivo, in humans, assess the metabolic and vascular effects of consuming NNS habitually; via a prospective, placebo-controlled, randomized, three-period crossover study. This research will also provide information about the role of type 1 sweet taste receptors (T1Rs), as well as oral sweet taste perception, in any potential NNS-mediated vascular/metabolic dysfunction. Ultimately, the findings from this research will inform policy makers about the safety of NNS, with the potential to lobby health authorities to revisit the regulatory status of these substances.

Keywords: non nutritive sweeteners,artificial sugars,vascular reactivity,vascular function,vascular dysfunction,metabolism,cardiovascular disease,obesity,insulin resistance
The first AI-driven smart-learning platform that teaches not only contents but also interdisciplinary skills as the key to success (Lernwolke)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the era of interconnected world, we are still approaching teaching with methodologies from the industrial revolution. The result of the one-size-fits-all approach is (in EU) a 22% of underachivers in mathematics, 18% in reading and 17% in science. To maximize the potential of the future EU workforce (the students of today) we need a change of the teaching paradigm. We need to provide students with advanced tools for achieving their curricular goals but also, we need to coach them to develop their interdisciplinary competences (self-esteem, self-criticism, etc.) to unlock their true potential. Today, most schools do not have the resources (time & money) to provide individual learning and parents must support their children with private tutoring, that cost up to 1000€ per child per year. There are multitude of smart learning platforms today (Duolingo, Smartick, etc.) but they lack the capacity to develop student interdisciplinary competences. As a result, most students give up e-learning platforms after 3 weeks. Tobias and Michael, primary school teachers (IT background) have committed to change this paradigm by developing lernwolke. Lernwolke is an affordable Artificial Intelligence (AI)-driven learning platform that provides individual learning paths to each student. Our uniqueness, however, relies in the human component of our AI. Teachers and coaches, supported by the AI engine, help develop the emotional competences of each student and facilitate reaching their learning objectives and develop as a person. As there are no set goals, but the goals are adjusted to the capability of each student, lernwolke eliminates the concept of failure that is so detrimental for children. Our confidence in lernwolke relies in the 4000+ students from over 40 schools that have already validated the potential of our technology and the 16 letters of support received. With lernwolke we plan to reach an EBITDA of by 22M€ by 2025 (ROI 15,8) while increase our team by 12 members

Keywords: ai powered interdisciplinary competences,smart education,ai powered soft skill development
Linking ecology, enzymes and ecosystems in the global nitrogen cycle (UNITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 1499631.0
EU funding (EUR): 1499631.0
Participants: 1
Project status: SIGNED

The global nitrogen cycle is of fundamental importance for our climate as well as agriculture, and both are facing significant threats due to environmental change. Anthropogenic input of synthetic ammonia-based fertilisers has a profound impact on the nitrogen cycle. Most soil ecosystems globally are nitrogen limited, necessitating ammonia-based fertiliser to achieve sufficient crop yield to feed the world’s growing population. However, circa 70% of fertiliser is lost through the activity of ammonia oxidising microorganisms, which contribute to the emission of the extremely damaging greenhouse gas nitrous oxide – a molecule with a global warming potential 300 times that of CO2, and also the most important ozone-depleting gas. Ammonia oxidising microorganisms are ubiquitous, highly abundant organisms. Despite their ubiquity and major environmental importance, they are some of the least well-understood microorganisms in the global nitrogen cycle. Several challenges contribute to the lack of our understanding: (1) Ammonia oxidisers are difficult to cultivate, (2) the molecular mechanisms driving their adaptation to different environments are poorly characterised, and (3) links between their cellular and physiological traits and the rates of nitrogen turnover are not understood. Consequently, it is difficult to interpret the ecological and environmental significance of many research findings. This research programme will bridge the gaps in our understanding of terrestrial nitrogen cycling using a combination of highly innovative methods. My research programme aims to reveal functions of uncultivated ammonia oxidisers and determine the important but overlooked role of cellular traits in nitrogen cycling rates in terrestrial environments. This study will provide a holistic framework of terrestrial nitrogen cycling from molecules to ecosystems and will deliver a major advance towards balancing the global nitrogen cycle.

Keywords: environmental microbiology,biogeochemical cycles,microbial physiology and metabolism
Genomics of Chromosome Architecture and Dynamics in Single Cells (GoCADiSC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 2497125.0
EU funding (EUR): 2497125.0
Participants: 1
Project status: CLOSED

The spatial architecture of mammalian interphase chromosomes, each consisting of tens of megabases of DNA, poses an intriguing topological problem and is relevant for various nuclear functions. A major challenge is that chromosome architecture exhibits substantial stochastic cell-to-cell variation. To unravel the principles of chromosome organization, new single-cell genome-wide approaches that capture the intrinsic variability are needed. Interphase chromosomes interact extensively with relatively fixed nuclear "landmarks" such as the nuclear lamina and nucleoli, posing considerable restraints to the spatial organization of chromosomes. For example, about one-third of the mammalian genome interacts with the nuclear lamina. We have recently developed two complementary methods to (i) visualize and track landmark – genome interactions in living cells, and (ii) generate genome-wide maps of these interactions in single cells. These new methods offer unique opportunities to unravel chromosome architecture, taking cell-to-cell variation and dynamics into account. Here I propose to take an integrative approach to study genome – landmark interactions in single mammalian cells. We will: (1) Extend our single-cell methods to visualize and map interactions of the genome with multiple landmarks, and with substantially enhanced genomic and temporal resolution; (2) Elucidate the dynamics and diversity of chromosome architecture in single cells, including differentiating cells; (3) Identify cis-determinants of chromosome - landmark interactions through systematic perturbation of linear chromosome organization, both by targeted mutagenesis and by a random scrambling approach; (4) elucidate the role of various proteins in the global and local control of single-cell dynamics of chromosome organization. These tightly linked approaches will provide detailed understanding of the dynamic architecture of chromosomes in individual cells, and yield new methods and resources.

Keywords: single cell genomics,interphase chromosome organization,dynamics,noise and stochasticity,nuclear lamina