Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Space & Earth Reliable greENhouse desIgn meThodologY (SERENITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

With a return of human exploration missions to the Moon in the mid-2020s and the preparation of more distant and longer-duration missions to Mars and further into the solar system, large-scale sustainable and reliable food production systems will need to be developed. Until now, only small-scale plant growth systems have been operated in space and they still pose numerous challenges. To be sustainable, greenhouse modules (GHM) for space need to use few resources, present low risk, be robust, reliable, and resilient. Therefore, this project aims at developing a methodology allowing space and terrestrial GHM design based on given constraints, using modelling, simulations, and optimization, with a process engineering and system engineering approach. The first objective is the analysis of constraints and objectives. This will be achieved after review and definition of environmental parameters constraints, criteria pertaining to GHM stability and reliability, and subsystem modelling, through extended literature review. The second objective is the systematic generation of competing designs using simulation tools based on constraints defined in objective 1. The interpretation of these results is the second part of this objective and is achieved with comparing different GHM designs, using criteria linked to used resources (energy, water, crew time), resources production (food, oxygen, water), as well as reliability, sustainability and risk. The third objective is the decision on a systematic approach to choose the best solution and provide recommendations for plant growth systems design in different gravity scenario. This project will fill the gap for the development of space and terrestrial food production systems and thus allow human exploration of Mars. It will allow Dr. Poulet to acquire the skills she needs to move her career forward and it will enable UCA Institut Pascal - GePEB to strengthen their international collaboration network with the space community.

Keywords: sustainability,life cycle,reliability,circular,bioregenerative,space,reduced gravity,life support systems,plant,greenhouse module,modelling,simulation,computational fluid dynamics
Narrative and Embodied Temporality: Revisiting Performativity (NETRePerform)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 1
Project status: SIGNED

Discussions on the relation between gender-forming discursive practices and biological reality inevitably turn to the body where nature and culture intersect. Is the body a mere “canvas” for symbolic practices to inscribe divisions and exclusions or does biological reality dictate divisions and limitations to symbolic practices? Both symbolic practices and biology rely on a temporal dimension that shapes the discussion: Is a historical or a discursive time able to effectuate these radical inscriptions or does biological time generate these practices? Our project will address this issue by synthesizing multiple perspectives. First, we will sketch an innovative framework for addressing embodied temporality by tackling from a phenomenological perspective the complex relation between time, body, and motivation. Our programmatic emphasis on motivation's relation to embodiment will initiate a series of innovative shifts. We will proceed to the dimension of language at the level of narrative. Dismissing recent naturalistic approaches, we will instead revisit Ricoeur’s work searching for a novel perspective that will allow us to reinstate the pertinence of narrativity. We will then address Butler's conception of gender-performativity by first carrying out an investigation of speech-acts and their temporal structure. Ricoeur’s and Butler’s respective critical accounts of speech-acts will serve as our guide. We will claim that non-discursive elements of speech-acts determine their temporal structure and we will thematize their bodily origin. Exploring the bodily involvement of motivation will form a novel framework that will allow our investigation of the embodied nature/culture intersection to move beyond the models of naturalization and performativity. We will be discussing with feminist and gender theorists who have variously thematized the problem of biological materiality.

Keywords: narrative,embodiment,temporality,performativity,phenomenology,hermeneutics
Federated foundational models for embodied perception (FRONTIER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Czechia
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2499825.0
EU funding (EUR): 2499825.0
Participants: 1
Project status: SIGNED

Computer vision is beginning to see a paradigm shift with large-scale foundational models that demonstrate impressive results on a wide range of recognition tasks. While achieving impressive results, these models learn only static 2D image representations based on observed correlations between still images and natural language. However, our world is three-dimensional, full of dynamic events and causal interactions. We argue that the next scientific challenge is to invent foundational models for embodied perception – that is perception for systems that have a physical body, operate in a dynamic 3D world and interact with the surrounding environment. The FRONTIER proposal addresses this challenge by means of: 1. developing a new class of foundational model architectures grounded in the geometrical and physical structure of the world that seamlessly combine large-scale neural networks with learnable differentiable physical simulation components to achieve generalization across tasks, situations and environments; 2. designing new learning algorithms that incorporate the physical and geometric structure as constraints on the learning process to achieve new levels of data efficiency with the aim of bringing intelligent systems closer to humans who can often learn from only a few available examples; 3. developing new federated learning methods that will allow sharing and accumulating learning experiences across different embodied systems thereby achieving new levels of scale, accuracy, and robustness not achievable by learning in any individual system alone. Breakthrough progress on these problems would have profound implications on our everyday lives as well as science and commerce with safer cars that learn from each other, intelligent production lines that collaboratively adapt to new workflows or a new generation of smart assistive robots that automatically learn new skills from the Internet and each other enabled by the advances from this project.

Keywords: embodied computer vision,self supervised learning,federated learning
Cultuurcampus: a sustainable hub of arts, research, learning and community as catalyst (CULTUURCAMPUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Coordination and support actions
Countries involved: Netherlands,Germany
Call: Support the deployment of lighthouse demonstrators for the New European Bauhaus initiative in the context of Horizon Europe missions (HORIZON-MISS-2021-NEB-01, 2021)
Start date: 2022-10-01
End date: 2026-06-30
Duration (months): 45.0
Total project cost (EUR): 4999216.29
EU funding (EUR): 4999216.0
Participants: 9
Project status: SIGNED

Cultuurcampus pilots a new approach to city making through education, research, policy and culture at the heart of Rotterdam South, an area which is exemplary of the complex challenges and diverse potential of Europe’s most disadvantaged urban areas. In our approach, we facilitate the coming together of different types of knowledge - theoretical, practical, from the arts and sciences - with the lived experiences of citizens. We do so in three ways. First, by co-creating a vibrant site of encounter, dialogue and shared learning. The Cultuurcampus will be housed in a historical building, the refurbishment of which unites a sustainable re-design vision of students of architecture and built environment, with the wishes and needs of local stakeholders, in a part of town where education and cultural institutions are scarce. This will be a hub for students, residents, social enterprise start-ups, lecturers and researchers – a place for learning, studying, community, art and culture. Second, we will facilitate empowering the co-design of impact-oriented learning curricula, that can make the area more sustainable, inclusive, and enriching. From sustainable crafts and repair workshops open to all, to lifelong learning formats and Master level courses, we will test innovative didactic approaches geared towards activating and inspiring citizens, students, and lecturers in shaping a better future for Rotterdam South. Third, we will ground our approach in participatory research and citizen science, that empowers residents to take part in the processes that shape their city and delivers a sound understanding of the area, its challenges and opportunities. Evaluating our experience, we will identify the most effective strategies for delivering territorial transformations that build on situated knowledge of an area and where the vision is shaped and implemented through multi-stakeholder and multi-level collaborations.

Keywords: education arts culture research interdisciplinary urban development architecture inclusion co design city making placemaking
Wrinkle-mediated Catalysis of 2D Materials (WILDCAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-11-30
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 2
Project status: SIGNED

The global climate and energy crisis demands decisive actions to implement sustainable energy production and utilization processes. Catalysis has demonstrated its importance down this route by enabling the transformation of abundant recyclable resources such as water and CO2 into widely utilized fuels and chemical feedstock. Customizing catalysts to improve the performance of these processes is one of the main pursuits of catalytic chemistry. A class of materials with atomically thin constituents, labelled 2D materials (2DM), exhibit widely tunable properties of interest for catalytic applications. On top of their high surface area, extraordinary mechanical properties, and great conductivity (thermal and electrical), they allow a precise control over their electronic properties beyond conventional metals and semiconductors. The tunable electronic properties of 2DM can be exploited to a great extent in order to tailor catalytic performance. In particular, it has been shown that perturbations such as dislocations, vacancies, edges, impurities and functional groups, readily modify the density of states in graphene and promote its catalytic properties. Although, mastering and translating these properties into catalytic specific applications is not an easy task. The present project will venture into the often overlooked and challenging front of nanoscale engineering of 2DM for catalysis. WILDCAT will employ morphological alterations in 2DM, such as wrinkles, for the facilitation of catalytic applications. By precisely engineering the geometry of these deformations, we can reversibly tune selectivity and susceptibility of chemical reactions, without inducing any structural defects. The catalytic responses will be assessed with advanced in-situ nanoscale characterization tools in order to probe the contribution of wrinkle engineering. WILDCAT has the ambition to expand our understanding of reaction engineering and pave the way for selective catalysts on-demand.

Keywords: atomic force microscopy afm,tip enhanced raman scattering ters,wrinkle engineering,selectivity
Causes and consequences of aberrant mRNA translation in cancer (pepTalks)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Shortages in amino acids are weapons in the warfare between tumor cells and tumor-infiltrating lymphocytes. Tumor cells enhance or inhibit the production of key amino acid metabolites to stimulate oncogenesis and suppress anti-tumor activity. A key player in this battle is tryptophan. Activated T cells secrete interferon-γ, which upregulates IDO1 enzyme to catabolize tryptophan to kynurenine in target tumor cells. While kynurenine suppresses T-cell function, its production limits tryptophan availability in tumor cells. Importantly, as tumor cells almost invariably deregulate mRNA translation to promote proliferation and metastasis, the consequences of tryptophan shortage are major. It provokes aberrant mRNA translation at tryptophan codons, resulting in ribosomal frameshifting and tryptophan to phenylalanine (W>F) codon reassignments (substitutants). This aberrant mRNA translation alters protein function and enriches the landscape of neoepitopes at the surface of tumor cells. Based on these observations, I hypothesize here that the detection of aberrant proteins in cancer specimens can reveal additional key processes of cancer progression beyond tryptophan that can be utilized for cancer therapy. To explore this exciting new idea, I designed three work packages (WPs): WP1 will expand the landscape of aberrant mRNA translation in cancer and link them to cancerous events. Preliminary results pinpoint arginine, histidine, and leucine. WP2 will generate reporter assays, set up functional genetic screens, and identify, validate, and explore key regulators of aberrant mRNA translation. WP3 will study the functional consequences of aberrant mRNA translation, and introduce novel therapeutic concepts. Altogether, this proposal will employ our recent discoveries of aberrant mRNA translation during periods of amino acid shortages to explore novel interplays between cancers and their suppressive microenvironment, and utilize this new knowledge for cancer therapy.

Keywords: mrna translation,amino acid shortages,cellular stress,t cells,adoptive immunotherapy,cancer
Enhancing Competitiveness, Resilience and Sustainability of Remote Farming, Forestry and Rural Areas through Holistic Assessment of Smart XG, Last-mile and Edge Solutions’ Gains (XGain)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Lithuania,Austria,Switzerland,United Kingdom,Croatia,Estonia,Cyprus,Belgium,Spain,Luxembourg
Call: Smart XG, last-mile and edge solutions for remote farming, forestry and rural areas (HORIZON-CL6-2021-COMMUNITIES-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4886149.0
EU funding (EUR): 4886149.0
Participants: 18
Project status: SIGNED

New trends such as teleworking and e-commerce, as well as the need for a further increase of digital tools in all sectors (i.e., health, education, transportation, farming, etc.) demanded by the Covid-19 pandemic, are pointing out once again digital territorial inequalities, supply-chain disruptions and deficiencies in economic opportunities that hamper resilience and prosperity of rural communities. Accessibility and connectivity are key issues to mitigate this erosion of socio-territorial cohesion. However, identifying a common solution for equipping rural communities with increased access to services, opportunities and adequate innovation ecosystems ensuring that no one left behind is a challenging task, mainly due to the diversity of challenges and needs of different locations. In this respect, XGain fosters a sustainable, balanced and inclusive development of rural, coastal and urban areas by facilitating access to relevant stakeholders, such as municipalities, policymakers, farmers, foresters and their associations, to a comprehensive inventory of smart XG, last-mile connectivity and edge computing solutions, and of related assessment methods. The XGain overall project objective is, to deliver a Knowledge Facilitation Tool, facilitating business model development, supporting decision-making in the selection of an ecosystem of technologies, consisting of connectivity options and edge processing solutions, by following a multi-actor and practitioner-oriented approach, and by coherently assessing their socio-economic and techno-environmental effects, aiming at: increasing systemic resilience and energy efficiency; contributing to climate mitigation; and reducing the digital divides between different types of citizens, farms, sectors and regions.

Keywords: xg connectivity and edge solutions for rural communities,innovative business models,fair and digital transition,bridging the digital divides between different types of farms,sectors and regions
Computational Design of Multimodal Tactile Feedback within Immersive Environments (ADVHANDTURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1999750.0
EU funding (EUR): 1999750.0
Participants: 1
Project status: SIGNED

These last years have seen an explosion of novel tactile technologies providing various haptic sensations across all the user's body. However, while these technologies have now been made available, virtual reality systems are still struggling to convey compelling tactile sensations for 3D interaction. As of today, tactile feedback mainly fails: (1) to render multiple haptic stimuli in a spatially coherent manner, (2) to achieve temporal integration of the stimuli compatible with the interactive framerates of immersive environments and (3) to preserve user's immersion within virtual worlds. ADVHANDTURE aims at targeting all the above limitations by introducing a ground-breaking computational approach for handling multimodal tactile feedback within immersive environments. My original methodology proposes for the first time the introduction of perceptual data at each step of the design of the computational models dedicated to immersive tactile haptics. Thanks to its innovative approach, ADVHANDTURE will address the design of: (a) physics-based models able to simulate the rendering of various tactile inputs, (b) computationally-efficient algorithms integrating multimodal tactile stimuli within immersive environments and (c) 3D interaction paradigms for combining multimodal tactile stimuli with multi-sensory information. In addition to significant advances in the design of computational haptic rendering models, ADVHANDTURE, in the long run, will considerably enrich our 3D interaction with virtual worlds by providing realistic multi-sensory feedback with multiple tactile sensations. Thanks to its multidisciplinary aspect, ADVHANDTURE will propose synergistic outcomes contributing to our understanding of the haptic perception of virtual worlds, as well as the underlying models in the fields of Computer Graphics, Haptics and Virtual Reality.

Keywords: haptics,virtual reality,physics based modeling and simulation,computational framework,perceptual measurements,3d interaction
Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eValuation of Microsatellite Instability in Endometrial Cancer (EVOLVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: CLOSED

Endometrial cancer (EC) is the most common gynaecological cancer, and has an estimated incidence rise of more than 50% worldwide by 2040, mainly associated with increasing obesity prevalence. In 2018 alone, there were approximately 380,000 new cases and close to 90,000 deaths attributed to EC worldwide. Thus, there is a growing need for the development of better platforms for inexpensive, early stage EC diagnosis and treatments. Immunotherapy has shown a sharp increase in survival rate in various cancers, but only in a small percentage of treated patients. The lack of reliable biomarkers for the selection of this sub-group of patients is a great hindrance to its broader application in the clinical setting. However, microsatellite instability (MSI) has been shown to be a good candidate for immunotherapy selection. MSI evaluation requires genetic material from tumors, which can be found in extracellular vesicles released by EC cells to the bloodstream. “Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eValuation of Microsatellite Instability in Endometrial Cancer (EVOLVE)” is thus a project focused on the development of an integrated solution for the enrichment and analysis of extracellular vesicles from body fluids of endometrial cancer patients to assess microsatellite instability using lab-on-chip, microfluidics methods in conjunction with DNA biomarkers and surface-enhanced Raman scattering technology.

Keywords: microfluidics,raman spectroscopy,extracellular vesicles,endometrial cancer