Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reconstruction of specialized metabolite evolution through molecular switches (ROSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498000.0
EU funding (EUR): 1498000.0
Participants: 1
Project status: SIGNED

Novel traits can provide fitness advantages and drive evolution. New specialised metabolites are traits that arose in different plant lineages, and even replaced existing metabolites. Why, and how almost universal metabolic pathways can be replaced in entire groups of species by biochemically distinct pathways without persistence of any species producing both metabolites remains unknown. Components of gene regulatory networks that control such pathways might act as regulatory switches that flip between pathways. The replacement of the widely conserved red pigment anthocyanin by the biochemically distinct betalains offers a unique opportunity to understand the integration of novel traits into existing regulatory systems. Notably, no plant species producing both anthocyanins and betalains has yet been identified, but both show similar environmental responses. The unification of systems biology with population and molecular genomics allows to elucidate the role of gene regulatory networks and regulatory switches in metabolite evolution. Given the great importance of understanding evolutionary innovation and the potential use for metabolic engineering, our work promises to be groundbreaking and have profound impact on many different fields of evolutionary and genetic research. Specifically, our work plan includes the following aims: I. Identify regulatory networks and switches that enabled the exchange of metabolic pathways II. Analyze the fitness consequences of reciprocal pathway exchange and regulatory switching III. Reveal the short-term selection consequences of metabolites during the domestication of food crops Understanding how metabolic pathways can be exchanged in plants will provide insights into the important embedding of evolutionary innovation into existing systems with potential practical applications for crop improvement and bio-engineering.

Keywords: specialised metabolites,gene regulatory network,plant evolution,domestication
Far-Away-from-eQuilibrium QANTUm Matter in 2D (FAQ-QuantuM2D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-02
End date: 2027-12-01
Duration (months): 24.0
Total project cost (EUR): 198557.52
EU funding (EUR): 198557.52
Participants: 1
Project status: SIGNED

Understanding the dynamics of quantum matter far from equilibrium is both challenging and has crucial implications for various fields, including statistical mechanics, condensed matter, high-energy physics, and quantum information theory. The difficulty arises from the prohibitive cost of classical simulations and the limited availability of analytical tools. This understanding is not only fundamental for quantum phenomena but also essential for advancing cutting-edge quantum computing technologies, a key global priority identified in the Horizon Europe Work Programme. While recent progress has been made in understanding one-dimensional interacting systems, the dynamics of quantum systems in two dimensions remain poorly understood. Strong indicators, such as the emergence of anyons, suggest that dynamics in two dimensions can be fundamentally different. This project, FAQ-QuantuM2D: Far-Away-from-eQuilibrium QANTUm Matter in 2 Dimensions, aims to advance the state of the art by leveraging a combination of analytical and numerical approaches. The project focuses on local quantum circuits, which are minimal models for many-body quantum dynamics that have led to groundbreaking analytical insights in recent years. Moreover, they are native to quantum computing applications. The proposal will advance our understanding of far-from-equilibrium dynamics and emerging dynamical phases of quantum matter through three specific scientific objectives: understanding localized and ergodic dynamical phases in 2D kinetically constrained models, understanding 2D strongly localized phases, and uncovering novel non-equilibrium dynamics unique to 2D systems. FAQ-QuantuM2D will deepen our understanding of quantum dynamics, yielding significant insights for fields focused on quantum dynamics and quantum technologies. Concretely for the latter, the results can be used for benchmarking quantum computers and finding suitable, classically hard, tasks for them.

Keywords: dynamics of quantum matter,nonequilibrium statical mechanics,quantum many body physics,exact solutions,quantum circuits,localization,quantum spin models,universal features of many body dynamics
Engineering, Analysis and Control of Biomolecular Circuits Under Uncertainty (CellWise)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1999107.5
EU funding (EUR): 1999107.5
Participants: 1
Project status: SIGNED

Synthetic Biology is one of the pillars of the bioeconomy. However, a number of fundamental issues need to be resolved before its full potential can be realized. First, the design of dynamic biomolecular circuits faces high levels of uncertainty from different sources leading to poor predictability of Synthetic Biology designs. Furthermore, there is an urgent need for more sophisticated biomolecular circuit functionalities to meet the demands arising from cutting-edge applications and scientific challenges such as the synthetic cell, including those related with cell cognition. CellWise aims to make a major contribution to the field by developing theoretical tools, and mathematical and computational methods to achieve enhanced predictability in Synthetic Biology. The objectives are: i) harnessing noise of different sources, uncertainty and context dependency for the precise engineering of complex biological functions, ii) fundamentally advancing the bifurcation analysis of biomolecular circuits under noise and uncertainty, and iii) achieving precise control of cell function, both at the single cell and population levels. The project has a special focus on the engineering and control of cell cognition capabilities such as memory and cell decision-making. To accomplish this, we propose an innovative mathematical modelling framework for dynamic biomolecular circuits under noise and uncertainty, combined with state-ofthe-art optimization methods, our recent insights on the automated design and bifurcation behaviour of stochastic systems, and experimental work. Through the realization of these objectives, CellWise will unlock innovative synthetic biology applications and improve our understanding of fundamental questions in biology, illuminating mechanisms by which cells achieve robust function in presence of noise, and elucidating how cellular decisions can be precisely controlled.
mRNA regulation of actin binding proteins (mRNArABP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovenia,United Kingdom
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 3
Project status: SIGNED

Cell shape is mostly controlled by the actomyosin cytoskeleton, composed of actin, myosin and multiple actin binding proteins (actin-BPs). Actin-BPs affect actin organisation and actomyosin contractility. While the mechanism of mRNA regulation of actin itself is well characterised, there is little research on the mRNA regulation of actin-BPs. Recently, the host lab discovered a novel mechanism of dose co-regulation for protein groups containing similar multivalency domains, termed interstasis. Certain actin-BPs contain multivalent C-rich regions making them a candidate protein group for mRNA regulation via interstasis. I propose to investigate the mechanism of mRNA regulation of actin-BPs, in particular those with C-rich mRNA sequences, and the possibility of feedback regulation. I will firstly identify RNA binding proteins (RNA-BPs) binding and regulating mRNAs of actin-BPs among RNA-BPs previously detected at the actin cortex and cell protrusions. I will specifically focus on identifying RNA-BPs binding to C-rich actin-BP mRNAs. I will identify the mechanism of action of these RNA-BPs via ribosome profiling, iCLIP, and smFISH. In the second part of the project, I will investigate whether C-rich actin-BPs mRNAs can be co-regulated and a potential feedback mechanism. In particular, I will use combinatory multivalency reporter to ask whether actin-BPs can be co-regulated via interstasis. Finally, I will connect mRNA regulation of actin-BPs to the actin organisation and processes affected by changes in actin organisation such as cell division and migration. To this aim, I will modulate the levels of RNA-BPs and actin-BP mRNAs and use microscopy to image the effects on the actin-driven processes. Together, I aim to further unveil molecular regulation of the actin networks during division and migration.

Keywords: actin organisation,homeostasis,rna regulation,mrna,actin binding proteins,rna binding proteins
Digitally enabled social district renovation processes for age-friendly environments driving social innovation and local economic development (drOp)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Estonia,Italy,Belgium
Call: Social and affordable housing district demonstrator (IA) (HORIZON-CL4-2021-RESILIENCE-02, 2021)
Start date: 2022-10-01
End date: 2025-12-31
Duration (months): 39.0
Total project cost (EUR): 2507255.0
EU funding (EUR): 2486150.0
Participants: 10
Project status: SIGNED

Housing policy in Europe is characterised by diversity; there is no single concept of ‘social housing’. In Spain, in the industrial development of the XX century, an extensive workers' housing policy was developed, and many social housing options appeared. The renovation of these districts and the refurbishment of this building typology (post-war privately-owned multifamily) requires heavy investment to alleviate situations of constructive pathologies, lack of energy efficiency and accessibility, and to adapt them to modern standards and the new requirements of their current users (often older people). The core ambition of the project is the development of an integrated renovation methodology aiming to transform social housing districts into inclusive smart neighbourhoods. It will guide constructive, energy and digital updates of neighbourhoods to improve urban space, accessibility and quality of life for all resident, and to guarantee connectivity of these neighbourhoods in physical, social and digital areas. The two drivers around which this project is structured are social innovation and local economic development both sharing the integration of innovative technologies as a guiding thread but with a human-centred approach and fit for purpose. The project will also explore the growth creation potential of cultural and creative industries (CCIs) in these processes of social neighbourhood renewal while strengthening social cohesion Based on an understanding of users’ needs, it will be validated through a use case in one social housing neighbourhood in Ermua (Spain). This process will be enriched by a peer learning method: Ermua will iterate with Elva (Estonia) as digitally advanced, and Matera (Italy), with their experience around the CCIs having been European Culture Capital 2019. This will also guarantee its replicability reinforced by Housing Europe, with the capacity to widely disseminate the IRM among its members as well as to foster and support its application

Keywords: urban regeneration,integrated methodology,active citizenship,co governance,ccis,digitalization,smart neighbourhoods,socio economic local development,bottom up renovation approaches
METabolic interplay petween peroxisome-endoplasmic reticulum contACT sites and mitochondria-endoplasmic reticulum contact sites during metabolic dysfunction-associated fatty liver disease (METACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the liver manifestation of metabolic syndrome, consisting in a hepatic accumulation of lipids. While MAFLD is predicted to concern near 50% of the global adult population in 2040, no medication has been developed to counter its progression. Recent studies have identified a novel interorganelle communication in the liver, that consists in the endoplasmic reticulum engaging contact sites with both mitochondria and peroxisome, hence termed as peroxisome-endoplasmic reticulum-mitochondria (PEWM) complex. Individually, mitochondria-endoplasmic reticulum contact sites (MERCS) and peroxisome-endoplasmic reticulum contact sites (PERCS) have been described to regulate mitochondria function and peroxisome biogenesis, respectively. Although the formation of a tri-organellar complex suggests an interplay between MERCS and PERCS, this has not been evaluated yet. Recent report have shown that lipid metabolism regulation affects PEWM complexes formation. Additionally, MERCS abundance correlates with the progression of MAFLD, further suggesting a role of PEWM complexes in MAFLD pathogenesis. We will develop innovative PERCS- and MERCS-specific imaging probes to evaluate how changes in energy substrates availability affect simultaneously the formation of MERCS and PERCS. Our second objective is to deepen the understanding of PEWM complex as a regulatory hub, by questioning whether and how the modulation of MERCS and PERCS alters the function of peroxisome and mitochondria, respectively. Furthermore, we will identify the components of MERCS and PERCS that impart their metabolic sensitivity. Finally, we will evaluate in vivo how integrity of PEWM complexes is regulated throughout the progression of MAFLD. We will study animal models of PERCS deficiency to assess their interplay with MERCS and their role in MAFLD pathogenesis. This could lead to the discovery of a novel therapeutical target for treating MAFLD.

Keywords: mitochondria function,inter organelles membrane contact sites,metabolic dysfunction associated fatty liver disease,pewm complex
RACE: ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at UoC (RACE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Greece
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The University of Crete (UoC), starting from humble beginnings, has evolved into a globally recognized institution. However, in competitive fields such as ageing research, UoC faces substantial challenges, including disparities between regional and European approaches, limited training programs, insufficient access to skilled personnel, and budgetary constraints that impede sustainable research and innovation excellence on-site. To address these pressing needs, UoC aims to recruit and fully integrate a distinguished ERA Chair with world-renowned expertise in science and management related to ageing research. The ERA Chair holder will establish the interdisciplinary research program, "RACE," as a unit of excellence dedicated to maximizing UoC's competencies, capacities, and expertise in ageing research. The RACE team will leverage UoC's state-of-the-art infrastructure, human capital, and expertise to address a major research topic with significant health-related and socioeconomic impact, building upon a well-structured, multi-disciplinary research program. The proposed ERA Chair initiative seeks to recruit and fully integrate the ERA Chair holder and the RACE team, enhance UoC's research capacity in ageing research, strengthen human capital through training in both research and soft skills competencies, increase competitive funding, and counteract brain drain for sustained development. Additionally, the initiative aims to foster innovation at UoC, enhance the management and administrative skills of the institution, leverage existing EU-funded infrastructures, and elevate the reputation of UoC through a comprehensive range of dissemination and outreach activities targeting the academic, private, and public sectors. Overall, RACE presents a credible path to fundamental structural changes, high-quality research, and impactful innovation that will transform UoC into an operational environment characterized by dedication, perseverance, and a commitment to excellence.

Keywords: ageing,genome instability,dna repair
EMBL Interdisciplinary Postdocs - Life in Context (EIPOD-LinC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,Hungary,Sweden,Netherlands,Lithuania,France,Denmark,Finland,Norway,Italy,Israel
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2026-01-01
End date: 2031-04-30
Duration (months): 64.0
Total project cost (EUR): 9644400.0
EU funding (EUR): 9644400.0
Participants: 16
Project status: SIGNED

EIPOD-Life in Context (EIPOD-LinC) is an interdisciplinary postdoctoral programme from the European Molecular Biology Laboratory (EMBL). Building on the success of prior EIPOD projects, EIPOD-LinC tackles critical challenges to human and planetary health by promoting international, intersectoral and interdisciplinary collaboration. It provides outstanding training to 57 international researchers recruited through a transparent, merit-based process, equipping them with the skills to bridge research, innovation and policy, fostering a new generation of researchers committed to addressing global challenges. Fellows design societally relevant interdisciplinary research projects that explore molecular mechanisms in natural environments. Research spans four key areas: Molecular Mechanisms, Human Health, Planetary Ecosystems, AI and Theory aligning with EMBL’s research programme Molecules to Ecosystems. Projects address urgent threats to human and planetary health, supporting EU Missions and the UN Sustainable Development Goals. Collaboration is central to EIPOD-LinC, with fellows working alongside EMBL group leaders and partners from the academic and non-academic sectors across EMBL’s 29 Member States. The programme’s bottom-up approach encourages dynamic collaborations, strengthening European research networks and promoting mobility within the European Research Area. Fellows receive cutting-edge interdisciplinary research and transferable skills training, coupled to professional career development support. EIPOD-LinC empowers them to make informed career decisions and develop skills that make them attractive to future employers in their chosen fields. Specialised training fosters innovative mindsets, instilling a strong sense of responsibility for science and society. Outcomes include enhanced career perspective for fellows and increased visibility and attractiveness of EMBL and institutes in its member states, contributing to Europe’s competitiveness and growth.

Keywords: inter disciplinary sectorial national,human and planetary health,training and career support,open science,research integrity,public engagement,sustainable science,innovation,science policy