Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Doing Intimacy: A Multi-sited Ethnography of Modern Chinese Family Life (Intimacy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2023-06-30
Duration (months): 93.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

Families in Western countries have received a great deal of attention from social scientists but there is less information on family life in other regions of the world. Given its growing rapidly in global influence, China represents a crucial region for sociological advancement and understanding. There have been profound changes in the Chinese family over the last century as a result of industrialization, urbanization, the influence of the West and the political interventions carried out by the Communist Party since 1949. Existing scholarship has shown how the structure and function of Chinese families have adapted to changing political and economic circumstances but little is known about the changes in intimate spheres of Chinese families. This project will approach the subject of modern Chinese family life from an unconventional angle, analysing it as a process of practices and experiences. By setting a new agenda that moves from structures of family relationships to the quality of relationships and through examining ‘doing intimacy’, this project will take a closer, fresher, critical look at the Chinese family dynamics as they are lived. Informed by the emerging literature on gender, intimacy and modernity, this project will examine intergenerational relations as well as gender and sexual relations in the family. Is there an intimate revolution taking place? How is ‘modernity’/’tradition’ closely linked with practices of intimacy? To what extent can doing intimacy be a site of empowerment/domination for women? What will the study of Chinese families tell us about agency and local/global change? Through a multi-sited ethnography (mainland China, Hong Kong and Taiwan), this study will also compare practices of intimacy in various sites and examine whether/how they are by-products of particular socio-cultural configurations. It will identify the extent to which changes in Chinese families mirror changes in the West and the factors that contribute to these changes.
Transition Metal Catalysis Towards Saturation in Organic Molecules through Alkyl Radical Chemistry (CatToSat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 36.0
Total project cost (EUR): 260840.64
EU funding (EUR): 260840.64
Participants: 2
Project status: SIGNED

The construction of C-C bonds represents the foundation of synthetic organic chemistry. Specifically, the installation of (sp3)-hybridized carbons is among the most important transformations in an organic chemist’s toolbox due to the prevalence of alkyl-alkyl bonds in organic molecules. Furthermore, compounds featuring a high degree of saturation grant access to greater chemical space and are more likely to yield clinical success in drug discovery and development. The overall aim of the proposed research is to devise new technologies in organic chemistry to access general, modular and applicable C(sp3)-C(sp3) bond-forming reactions, providing high degrees of saturation in organic molecules. Transition metal catalysis will be the foundation for this proposal, in which the most accessible sources for reagents will be used, such as ubiquitous alkyl carboxylic acids and feedstock olefins. In order to accomplish the overarching goal of this research program, the outgoing phase of this fellowship will take place during the first two years in the laboratory of Prof. Phil Baran at Scripps Research, La Jolla, USA. The incoming phase will take place during the final third year in the laboratory of Prof. Bill Morandi at ETH Zürich, Switzerland.

Keywords: cross coupling chemistry,electrochemistry,single electron transfer
Design, synthesis, study and applications of distorted nanographenes (NANOGRAPHOUT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-09-30
Duration (months): 78.0
Total project cost (EUR): 1492675.0
EU funding (EUR): 1492675.0
Participants: 1
Project status: CLOSED

Graphene is considered a very promising material. Perfect samples of graphene without structural defects are extremely electrical and thermal conductive. However, defects usually appear during the production of graphene, modifying its thermal, electrical and mechanical properties. If we understand the influence of imperfections on the properties of graphene, we may tune its local electrical properties by controlling the presence of defects, leading to new organic semiconductor materials. We aim to embed seven- and higher membered rings into an otherwise planar NANOGRAPHene lattice as a new tool for the preparation of innovative materials for organic electronics. These defects would induce a curvature in the planar sheet distorting the structure OUT of the plane. NANOGRAPHOUT focuses on providing a general synthetic method for the construction of a variety of distorted nanographenes with good control on size, shape and the edges of the final compounds. Key synthetic steps include alkyne cyclotrimerization and cyclodehydrogenation reactions. By evaluating the morphology, optical and electronic properties and electron transport of synthesized nanographenes, we aim to establish the first comprehensive study clarifying the influence of defects on the properties of nanographenes. We will test electrical transport properties of selected compounds in organic thin-film field-effect transistors (OTFTs) laying the foundation for using distorted nanographenes as organic semiconductors based on pi-pi interactions. With the same bottom-up approach based on organic synthesis we intend to present nanographenes with helical chirality. Adding chiroptical response to the semiconductor properties of nanographenes will provide the new devices the added value of their potential application in photonics. As proof-of-concept, we plan to implement helically chiral distorted nanographenes as active layer in OTFTs and evaluate their use as elliptically polarized light emitters and detectors.

Keywords: alkyne cyclotrimerization reaction,dehydrogenation reaction,nanographene,graphene defects,helical chirality
A new method for separation full recovery of multilayer packaging waste to create high value materials - LAMPACK (Lampack)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-10-01
End date: 2017-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The food manufacturing sector has been producing multi-layered packaging since the ‘70s and are commonly comprised of layers of PET/PP/PE/PA. Over 40m tonnes of multilayered plastics are produced globally, per annum, of which the EU contributes 9.6m tonnes, with an expected growth of ~7%. However, due to the extreme difficulties in achieving effective seperation of the material into its constituent polymer components, multi-layered plastic waste is currently collected as a single waste stream & disposed of through landfill (at costs of €130 per tonne), or incinerated (~€80 per tonne). Thus, the future of multilayer packages is now a great environmental concern, with an urgent need to develop effective separation technology. Our objective is to develop an ultrasonic assisted chemo-mechanical recycling method to separate multilayered plastic packaging waste (semi-rigid trays, cups, tubs & their film-based lids), currently deemed unrecyclable, and recover polyethylene (PE) & polyethylene terepthalate (PET) individually in order to sell these end products in the EU recycling market & thereby create a new business opportunity of ~€4.8bn. Successful development of this technology will create the business opportunity to recycle this material, generating new revenues while reducing waste, landfill, energy & saving ~14.4m tonnes of CO2 emissions per annum. Our novel process will not only ensure the sustainable supply of these plastics as raw materials via environmentally friendly recycling but will also provide participating SMEs with the opportunity to derive an ongoing income. It is envisaged that the potential benefits of the LAMPACK technology would be: • Annual value for recovered PET per plant of €3.5m • Annual value for recovered PE per plant of €5.2m • Energy savings of €1.6m p.a per plant • CO2 reduction of ~ 22,500tpa per plant

Keywords: layered packaging polymer ultrasonic separation film waste
Exploiting vulnerabilities in protein synthesis for cancer diagnosis and therapy (Diricore)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-05-01
End date: 2016-10-31
Duration (months): 18.0
Total project cost (EUR): 149500.0
EU funding (EUR): 149500.0
Participants: 1
Project status: CLOSED

Tumor growth requires continuous synthesis of proteins, nucleic acids and lipids that are important components of the cell. Demand for amino acids as the building blocks for protein synthesis in rapidly dividing tumor cells is often much higher than that of normal cells. Such increased demand can represent a vulnerability of the tumor. Importantly, this vulnerability is already being exploited for therapy in one instance: Addition of L-asparginase - an enzyme lowering the concentration of the amino acid asparagine in blood - to chemotherapy against acute lymphoblastic leukemia, resulted in a dramatic increase in cure from 5% to 95% of patients treated. Recent scientific publications highlight the fact that tumors are often metabolically rewired, and multiple examples of altered amino acid demand and/or turnover have been demonstrated in different cancer indications. Multiple drugs are under development that target amino acid availability, uptake or biosynthesis. The challenge is to identify the potential sensitivity of individual tumors to such drugs. Recently, we developed diricore, a procedure for determination of restrictions in the availability of particular amino acids for protein synthesis. To demonstrate the potential for diricore’s diagnosis capability in cancer, revealing proline limitations for protein synthesis in kidney cancer. We also used kidney cancer cell lines to verify sensitivity to proline deprivation, suggesting therapeutic possibilities. We propose here to develop diricore towards a commercial diagnostic platform for determining limiting amino acid availability profiles in cancer patients. This information will guide physicians in taking dietary measures or prescribing drugs that inhibit amino acid uptake or biosynthesis.

Keywords: cancer diagnosis,protein synthesis,ribosome profiling,amino acid deprivation
Targeting the Oncogenic Function of Myc in vivo (TarMyc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1497905.0
EU funding (EUR): 1497905.0
Participants: 1
Project status: SIGNED

The transcription factor Myc plays a central role in tumourigenesis but was deemed undruggable due to it being an essential protein. However, recent proof-of-principle studies in mice using a dominant negative allele of Myc demonstrated the dependency of established tumours on Myc function and showed that mice tolerated Myc inhibition to a degree that allowed tumour regression. In line with these observations my group found Myc to regulate distinct sets of genes at low, physiological and high, oncogenic levels, because promoters differ in their affinity for Myc. This notion implies the compelling possibility to specifically target the oncogenic functions of Myc. TarMyc aims to address four key questions required to bring this new concept from bench to bedside. Firstly, TarMyc will estimate the therapeutic window of Myc inhibition in vivo by expressing shRNAs against Myc in mice with established solid tumours. Secondly, TarMyc aims to identify in vivo Myc target genes crucial for tumourigenesis. Thirdly, this proposal aims to elucidate the role of Myc’s differential promoter affinity in untransformed cells. Analysis of published gene expression datasets revealed Myc binding to low-affinity promoters during the process of tissue regeneration. Thus, by characterizing the regeneration programme induced by Myc we hope to gain further insight on the therapeutic window of Myc inhibition and assess potential side-effects in a Myc-targeting anticancer therapy. Fourthly, we aim to develop strategies to interfere with the oncogenic functions of Myc by (i) developing a novel class of drugs that reduce Myc’s cellular concentrations, and (ii) by testing the therapeutic potential of Myc target genes by inhibiting their function in tumour models. Taken together, TarMyc takes on the challenge of inhibiting the oncogenic functions of Myc in a highly multidisciplinary approach using state-of-the-art molecular biology, advanced tumour models and new concepts in drug development.

Keywords: cancer,therapeutic window,protacs,organoids,transcription factor,gene regulation,chip sequencing,rna sequencing
Sustainable Policy RespOnse to Urban mobility Transition (SPROUT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Spain,Italy,Italy,Germany,Spain,China,Belgium,Hungary,Poland,Belgium,Greece,Romania,Sweden,Greece,Poland,France,United States,Netherlands,Portugal,United Kingdom
Call: Harnessing and understanding the impacts of changes in urban mobility on policy making by city-led innovation for sustainable urban mobility (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 4412553.75
EU funding (EUR): 3865116.25
Participants: 32
Project status: SIGNED

SPROUT provides a new city-led innovative and data driven policy response to address the impacts of the emerging mobility patterns, digitally-enabled operating & business models, and transport users’ needs. Previously tested and implemented policy responses employing access restrictions, congestion charging or infrastructure provision, seem today, unable to adequately address the changes underway in the urban mobility scene. Furthermore, any policy responses should take into all stages of the policy lifecycle and should have an eye not only to the present but also to the future. Therefore, starting from an understanding of the transition taking place in urban mobility, SPROUT will define the resultant impacts at the sustainability and policy level, will harness these through a city-led innovative policy response, will build cities’ data-driven capacity to identify, track and deploy innovative urban mobility solutions, and will navigate future policy by channelling project results at local, regional, national and EU level. To achieve its goals, SPROUT will employ 6 city pilots (including China) with real-life policy challenges faced as a result of urban mobility transition in both passenger & freight, covering urban and peri-urban areas, different emerging mobility solutions, and context requirements. The project pays special attention to the needs of vulnerable groups and users with different cultural backgrounds, taking also into account gender issues. SPROUT ensures an active participation of numerous representatives from authorities of small & medium-sized cities through a 3-layer structure of cities’ engagement approach, and through the creation of an Open Innovation Community on Urban Mobility Policy.

Keywords: city led innovative policy response,passenger and freight urban mobility,urban mobility policy,emerging mobility solutions
LifeCall Wearable EKG Heart Health Monitoring, Analysing and Warning System (LifeCall)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Türkiye
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cardiac arrest is the leading cause of death that annually more than 17 million die in the World, 3 million in Europe. Worldwide 320 billion$ is spent for medication and diagnostics. EKG is a critical element of heart health. The longer we record EKG, deeper the diagnosis we can achieve. LifeCall is a mobile, wearable EKG device which captures real time EKG and stores it remotely to share with related parties. It consists of a shirt with newly developed innovative conductive textile electrodes and a device which can read real time EKG and sends it to our mobile application. It has no gel based electrodes since we use a special textile that can conduct low voltage electricity. This use of the nanotechnology based textile is unique. Our system can record EKG almost for 3 weeks without interruption, with low energy components, optimized wireless transactions. This can open up new era to health care industry. Critical life threatening heart events can be captured before actual damage is done, with just a basic shirt and its supporting ecosystem which is not possible with conventional hospital holter EKG. There will be 2 separate products that will be commercialized individually: 1) A shirt and accompanying device that captures real time EKG data. The device will pass EKG data to mobile phone for recording which will later be pushed to our servers in a secure and private way. 2) A platform for analysing, routing and sharing of these EKG outcomes with related parties through mobile and desktop applications. Our target end-users can be considering anyone that may have cardiovascular risk who is between 40 to 65 years old with arrhythmia complications, but pinpointing maximum impact complication is also a target of our feasibility study. In phase 1, we will conduct a feasibility study on market, pinpoint maximum impact hearth complication, risks, strategy and financial requirements. In phase 2, we will deliver the product based on phase 1 outcome.

Keywords: wearable technology,heart attack,remote diagnostics,wearable electrocardiogram
Spectro-mapping of the circumgalactic medium across cosmic times (SPECMAP-CGM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 2459123.75
EU funding (EUR): 2459123.75
Participants: 1
Project status: SIGNED

This project aims at developing a radically new view on the structure and dynamics of gas flows in the surroundings of galaxies, a domain known as the circumgalactic medium (CGM). In the last years it became clear that the CGM is crucial for our understanding of galaxy evolution, which are largely shaped in the CGM by the interplay of inflows from the intergalactic medium and outflows driven by supergalactic winds. I plan to investigate the CGM of normal galaxies by means of integral field spectroscopy, or spectro-mapping, in various emission lines. I bring privileged access to two new major astronomical facilities, MUSE on the ESO Very Large Telescope in Chile, and HETDEX on the 10m Hobby-Eberly Telescope in Texas. These instruments are both unique in their capability of performing integral field spectroscopy over unprecedented fields of view, delivering high-quality spectro-mapping information for hundreds of galaxies and their circumgalactic environments simultaneously. I have a leading role in both, and I am the only astronomer in the world with direct access to MUSE Guaranteed Time Observations and to the entire HETDEX survey. The major challenge for this experiment is the extreme faintness of the CGM emission, which so far made spectro-mapping unfeasible except for a few extreme objects. My recent breakthrough discoveries with MUSE of ubiquitous Lyman-alpha haloes around high-redshift galaxies demonstrate that finally we have achieved the sensitivity required to detect the CGM directly in emission through imaging spectroscopy. I now want to go a big step beyond and apply this approach to large representative samples of typical galaxies at all redshifts. My goal is not only to detect and establish line emission from the CGM as a universal phenomenon, but to disantangle its complex substructures and, through comparisons with physical models and the latest numerical galaxy formation simulations, build a comprehensive picture of these processes.