Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Polarized light from highly phosphorescent metalomesogens (POLOGEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-04
End date: 2015-10-03
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Phosphorescent cyclometalated transition metal complexes are attracting continously growing attention as highly efficient emitters for organic light emitting devices (OLEDs), bioimaging, sensors, and photocatalytic reactions. To improve their performances in solid state electrical devices, it is important to ameliorate charge transporting properties of the materials by imparting some degree of order in the bulk of the materials. Furthermore, this order would open the possibility of polarized emission useful for sensors and backlights for liquid crystal displays (LCDs). Developing liquid crystalline iridium(III) complexes is a promising approach to provide order in phosphorescent organic materials. This proposal will develop new liquid crystalline iridium(III) complexes with improved emission quantum yield in condensed phase and highly polarized emission.

Keywords: polarized phosphorescence,cyclometalated iridium compelxes,liquid-crystals,optoelectronic organic materials,condensed organic phases
A Kantian Approach to Current Tensions between Modern Law and Religious Commitments (LAW AND RELIGION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-23
End date: 2015-09-22
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

The proposed project is a multidisciplinary collaboration among Dr Mehmet Demiray (the prospective MC fellow), a post-doctoral researcher in the field of political and legal theory, from Kocaeli University in Turkey; Dr Sorin Baiasu (the team leader), a prominent scholar in the field of Kantian practical philosophy, from Keele University in the UK; and Dr Brian Doherty (the research advisor), a well-established scholar in the field of political sociology, from Keele University. The research will deal with the problematical relations between modern law and religious commitments, as they have been arising in contemporary European societies and Turkey, e.g. the French ban on face-veils, Köln state-court’s decision against boys’ circumcision, the new Turkish law on education envisioning courses on the Koran and the life of Mohammed the prophet in public schools, and Turkish government’s recent proposal of a law banning abortion and caesarean-births. The research objective are to: (1) develop a much needed theoretical framework accounting for the nature of law and its relation to moral commitments in a way that cogently reconciles universalistic orientation (characterizing adherence to human rights) with sensitivity to the fact of pluralism characterizing contemporary world; (2) generate practical suggestions and policy-recommendations by applying this improved framework to the contemporary instances exhibiting intricate forms of tension/conflict between law and religious commitments, with which Europe and Turkey are currently faced. General objectives of the project are to: (1) create long-term research collaboration between Kocaeli University, the researcher’s home university in Turkey, and Keele University in UK, the host university in this project; (2) enable the prospective fellow to master the Kantian philosophical methodology Baiasu has been working up for several years; (3) improve the experience and international research network of the prospective fellow.

Keywords: s210 philosophy - history of philosophy,s110 legal systems - constitutions - foundations of law,s109 political systems - legitimacy of governance,s212 ethics and morality
Requirements Engineering and Systems Architecting Case Studies (RESACS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-06-01
End date: 2014-08-31
Duration (months): 15.0
Total project cost (EUR): 152404.87
EU funding (EUR): 152404.87
Participants: 1
Project status: CLOSED

Among the critical areas of software development are Requirements Engineering (RE) and Systems Architecting (SA). There is a high degree of interaction between these two processes. While these processes have been researched in terms supporting technology, there is a distinct lack of empirical understanding regarding the scientific properties of the interaction between RE and SA. Without such empirical understanding, clearly, technical-solution proposals are less likely to be effective in practice. Thus, this proposal seeks to investigate: (1) the impact of an existing system’s architecture on the risks associated with new RE decisions; (2) the role of simulation in the engineering of the requirements of complex systems; and (3) the guidelines that can be used to support the extraction of generalisable requirements and architectural patterns from a prototypical project’s information base for use in developing production systems. These are novel objectives. The significance of the first two objectives is that they would give transparency to the analysts and stakeholders, during requirements change, as to the risks involved in changing and implementing new requirements. Assessment of such risks would be invaluable for negotiation with customers and in system design and technology development. The significance of the third objective is that the cycle-time, effort, and hence cost, for transitioning projects from prototype to production stages could reduce considerably because of the use of established guidelines. This is of strategic importance as we transition more and more “green” prototype systems into production systems. The research approach to be used will entail conducting case studies of a significant prototype automated train project (RailCab). The application domain is thus “mechatronics” (i.e., mechanical engineering, electronics, and software engineering), making this investigation inter-disciplinary.

Keywords: requirements engineering (re),software architectures (sa),systems engineering,re-sa interaction effects,simulation in re,requirements change,project risk,empirical research.
Preclinical studies in mouse hematopoietic stem cells for gene therapy of Wiskott-Aldrich Syndrome (WASHSCGENETHERAPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-02-01
End date: 2016-01-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Wiskott-Aldrich Syndrome (WAS) is a primary X-linked rare disease (1:250.000 mainly children) caused by mutations in the was gene. Gene Therapy (GT) results in Primary Immunodeficiencies (PID) have been particularly successful due to advances in gene modification of hematopoietic stem cells (HSCs). Currently there is a clinical trial which has developed an ex vivo approach that uses a HIV-derived lentiviral vector to transfer genes into autologous CD34+ HSCs from WAS patients. This clinical study, initiated in 2010 in London by the team of Professor Thrasher, is also conducted in Paris and in Boston. Our laboratory has developed therapeutic lentiviral vectors (LVs) for GT of WAS (WW y AWW) (Martin et al. 2005; Frecha et al. 2008) that express WASP phisiologically in T cells of WAS patients and restore normal functions of T cells, dendritic cells and macrophages WASP-deficients. Also, the transduction of WASP deficient cells with WW confers a growth selective advantage. Given that the HSCs are the therapeutic target for WAS GT, the first objective of this project is to check the capacity of AWW, WW and the therapeutic vectors currently in use in clinical trial (NCT01347242) in the phenotipic restauration of WAS knockout mice (WASKO). For that purpose, we will transduce mHSCs of WASKO mice with these LVs and inject them in WASKO irradiated mice to the analysis expression, in terms of the WAS restore capacity of different hematopoietic populations. The second objective will be to improve safety and efficiency of gene transfer vectors for WAS gene therapy. We will include insulator sequences (INS) in our therapeutic SIN-LVs expressing was cDNA through its own promoter. New AWWINS y WWINS vectors will be compared in term of efficiency and safety using WAS-deficient T cells and tumour-prompt mice models. Based on these results we will develop stable producer cell lines for WAS GT applications.

Keywords: wiskott - aldrich syndrome (was),gene therapy (gt),lentiviral vectors,was-promoter,hematopoietic stem cells (hscs),was knockout mice,care model
Vegetation shifts in desert environments: a multi-scale ecogeomorphic approach for the analysis of grassland-shrubland transitions (VEGDESERT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-16
End date: 2015-07-15
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Climate change and the massive alteration of natural habitats are major drivers of land degradation. Their effects may be especially significant in drylands, where ecosystems are particularly sensitive to degradation, usually involving irreversible landscape changes (i.e. desertification). A common form of desertification in drylands includes the encroachment of shrub species into historic productive desert grasslands. An array of mechanisms are involved in shrub encroachment processes, including external triggering factors such as climate and land-use variations, and endogenous amplifying mechanisms brought about by soil erosion-vegetation feedbacks. Within this context, the present mobility project will investigate grassland-shrubland transitions in desert environments. The ambitious objective of this project is to develop an ecogeomorphic framework for the analysis and prediction of rapid vegetation shifts in semi-arid grasslands threatened by shrub encroachment processes. The project will be hosted by Durham University (UK) and will focus on grassland-shrubland transitions in the Chihuahuan desert, taking advantage of the information and facilities available at the Sevilleta Long Term Ecological Research Station (New Mexico, USA). The influence of a variety of triggering factors (i.e. precipitation variations and grazing) and the impact of soil erosion-vegetation amplifying feedbacks on these vegetation changes will be studied using an innovative approach that will integrate both remote sensing information of vegetation phenology and experimental data across different scales; with ecogeomorphic modelling and robust model testing against existing data sets. The results of this project will contribute to the understanding of the processes that regulate the dramatic changes that are taking place in arid and semiarid landscapes worldwide, and will provide practical tools for the management of dryland landscapes threatened by desertification.

Keywords: desert environments,desertification,drylands,ecosystem stability thresholds,land degradation,modeling,remote sensing,soil erosion-vegetation dynamics,spatial patterns,vegetation shifts
Capacity and Energy Efficiency Limits of Wireless Communications for Heterogeneous Long Term Evolution Advanced (LTE-A) Deployment (CAREER LTE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-05-15
End date: 2016-11-14
Duration (months): 30.0
Total project cost (EUR): 315923.45
EU funding (EUR): 315923.45
Participants: 1
Project status: CLOSED

Approaching new horizons of capacity and energy efficiency is foundational for next-generation broadband wireless communications. Toward this goal, the IOF proposal “Career LTE” pursues fundamental research with inter-disciplinary efforts, and integrates the outcome with engineering practice, to push forward the state-of-the-art of performance and energy efficiency for heterogeneous Long Term Evolution Advanced (LTE-A) deployment. Capacity and energy have been dealt with from the perspectives of information theory, optimization, physical layer technologies, and networking. To go beyond the cutting edge, the time has come to depart from each of these perspectives alone, toward producing new knowledge by synergizing these fields. The outgoing phase develops computational models for analyzing emerging capacity-enhancing concepts, and investigates fundamental performance-energy tradeoffs. Here, the fellow extends his knowledge with information theory, and cross-layer and green networking, and fuses them with his strong background in optimization and industrial experience in 4G radio access. Integrating the molded knowledge with the fellow’s experience in European industry, the return phase develops new methodologies for energy-efficient heterogeneous LTE-A deployment. The applicant has an excellent track record in publications and funding, along with industrial experience. His professional achievements so far demonstrate his ability to quickly absorb new knowledge and develop leadership skills. In addition to the scientific objectives, the IOF project benefits: 1) the fellow’s long-term career goal of becoming a world-class ICT research leader, 2) a long-standing European-USA research and educational link for life-long learning, 3) the formation of a knowledge-dynamic team to attract young and talented researchers for careers in ICT Europe, 4) European industrial competitiveness by turning scientific findings into innovation via the fellow’s background at Ericsson.

Keywords: g208 networks,g202 electrical and electronic engineering,m119 application of mathematics in sciences
A Mathematical Study of Electronic Transport in Aperiodic Media (ETAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

We aim to obtain a rigorous mathematical description of transport and conductivity properties in aperiodic structures exhibiting a long-range geometric order with or without an additional energetic (stochastic) disorder. In a first stage we aim to show that dynamical localization and pure point spectrum for Delone operators modelling aperiodic media is a typical feature in the space of all Delone operators in a sense to be defined, that is expected to be stronger than generic. We aim at exploring the universality of localization in geometrically disordered systems. In the process, we will develop a topological version of the Multiscale Analysis, and we will strive to isolate the geometric properties of the Delone sets for which the associated operators exhibit pure point spectrum. Next, we proceed to derive rigorously the linear response theory and Kubo formula in order to compute conductivities in disordered aperiodic systems, in both the single-particle as the N-particle case. For the latter, we aim at showing the existence of conductivity measures and the vanishing of dc-conductivity at zero temperature. To obtain rigorous results on conductivity properties we will make use of tools from the theory of Delone dynamical systems, plus the latest developments in techniques to prove localization in the theory of random Schrödinger operators.
Exploring the biological significance of phenotypic heterogeneity in Pseudomonas (BIOSIGHET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-04-01
End date: 2016-01-12
Duration (months): 24.0
Total project cost (EUR): 192622.2
EU funding (EUR): 192622.2
Participants: 1
Project status: CLOSED

Phenotypic heterogeneity – physical diversity amongst genetically identical individuals exposed to the same environmental conditions – is a phenomenon that has caught the interest of biologists for decades. Although recent technological advances have revolutionised our understanding of the mechanistic bases of phenotypic heterogeneity, its adaptive significance and associated biological function(s) remain largely obscure. Two hypotheses have been proffered: (i) the “bet hedging” hypothesis, which postulates that phenotypic heterogeneity is a risk-spreading strategy facilitating population survival in uncertain environments, and (ii) the “division of labour” hypothesis, which proposes that phenotypic heterogeneity can increase population efficiency by partitioning labour (or resources). However, despite great interest in this area, empirical evidence for the biological significance of phenotypic heterogeneity is severely lacking. Here, I propose a series of experiments that combine molecular genetics, state of the art single cell analysis techniques and metabolomics to directly test the biological significance of a recently characterised example of phenotypic heterogeneity: ON/OFF colanic acid capsule expression in the bacterial model system Pseudomonas fluorescens SBW25. By providing a direct, experimental test of hitherto theoretical hypotheses, the proposed experiments have the potential to provide some of the first empirical insight into why phenotypic heterogeneity is such a widespread phenomenon. In addition to being of academic interest, our results will have direct relevance for industries involved in the management of infectious microbes (public health, veterinary science and agriculture) and the use of microbes in product manufacture (biotechnology) and toxin breakdown (bioremediation).

Keywords: l607 microbiology,l802 population biology - population dynamics - population genetics,l204 metabolomics,l101 molecular biology and interactions,v305 ecology
Targeting Norovirus Receptor Interactions at Atomic Resolution (NOROCARB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Norovirus infections affect more than 200 million people worldwide every year. Since these viruses are highly contagious and cause epidemic outbreaks norovirus infections constitute a massive economic burden. Currently there are neither vaccination strategies nor therapeutics to cure the infection. We have designed first prototype entry-inhibitors against norovirus infections employing a rational approach based on NMR binding studies with virus like particles (VLPs). In order to develop these prototype inhibitors into potent antivirals information is needed on the thermodynamics and kinetics of binding of entry-inhibitors to the viral coat protein VP1. Binding data will be related to binding topologies on the surface of VP1. We suggest protein NMR experiments with selectively 2H/15N/13C amino acid labeled VP1 to study the relative binding topologies of natural attachment factors and entry-inhibitors. Isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) will yield enthalpies and entropies of binding as well as kinetic data on the binding process. Thermodynamic data in combination with relative binding topologies will then deliver guides for the rational modification of the first generation inhibitors to obtain better affinities. The modified compounds will be subjected to the same set of experiments, and depending on the results the optimization process proceeds in an iterative manner until potent entry-inhibitors are identified. Since VP1 is expressed as a homodimer (P-dimer), potent inhibitor candidates will be linked to a polymeric backbone as described earlier in order to achieve better avidity. Finally, we hope to come up with a first rationally designed entry-inhibitor against norovirus infections.

Keywords: norovirus,blood group antigens,entry-inhibitor,nmr-spectroscopy,isothermal titration calorimetry (itc),surface plasmon resonance (spr),cell free protein synthesis,stable isotope labeling