Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Noc ima svojo moc (The Night has its Might), European Researchers' Night (NIGHT) (NOCMOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Slovenia
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-16
End date: 2024-02-15
Duration (months): 21.0
Total project cost (EUR): 419376.5
EU funding (EUR): 419376.5
Participants: 6
Project status: CLOSED

Engaging local, regional and national media, an introduction with awareness campaign Soil' Might will bring the project NOCMOC [NIGHTMIGHT] to Slovenian and other EU citizens for the fifth time. The core objectives of the project is to raise awareness about the research and its benefits, overcome stereotypes, stimulate curiosity and excite youth to take up the research careers. Efficient communication tools, successfully used in previous project editions, TV, radio, social media and press conferences will address 1.500.000 citizens during the project. The awareness campaign will explore Soil and include 3.000 groups, families and individuals to participate in Citizens Science project. Citizens' contribution to the basic research methodology of the real research project will be implemented by use of »hands-on« and other research tools in a simple and user friendly manner. Previous editions have developed a growing network of supporting partners in more than 25 cities in Slovenia and cooperation with Italian ERN SHARPER with which it attracts youth research career paths with EU dimension events. The NIGHT will bring together over 66 research-related institutions, raise awareness about research and innovation, its relevance to implement the Green Deal goals, its social and economic benefits and enhance a variety of research careers for 100 researchers, visiting 140 schools. We aim for 74.000 visitors from different target groups to take part in the NOCMOC activities spread all over Slovenia. Over 200 activities: science festivals on the main squares of four Slovenian cities, science shows, simulations, research and technical days in primary and secondary schools, lectures and workshops in public spaces (libraries, retirement homes, museums), science espressos, STEAM events, EU corners, on-line events and open doors of science, research and cultural institutions will attract the audience from dawn to late evening each last Friday in September two years in a row.
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgans (THOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,France,Italy
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3994150.0
EU funding (EUR): 3994150.0
Participants: 6
Project status: SIGNED

Tenths of millions of people with organ failures or suffering from degenerative diseases are waiting for a novel cellular therapy or for a transplant of a donor compatible organ and the immense majority of these patients will die before receiving the tissue or organ they need. Despite the significant advances in tissue engineering, not a single artificial tissue has been used to replace a part of an organ, with the exception of simple or avascular tissues like skin or cartilage. THOR proposes the development of a revolutionary tissue engineering technology, capable to produce any type of human tissue for organ repair or replacement in case of illness, trauma or degenerative diseases. Patient-tailored tissues will be fabricated by pools of bioinspired mini-robots in fully automated production plants, using the breakthrough incremental technologies of the THOR project: self-assembling molecules inspired to the extracellular matrix; self-assembling solid and hollow polymeric fibers; materials functionalization using photoactivable crosslinkers; cutting-edge mini robots to wave 3D self-assembling structures with factors and cells with micrometric precision. THOR tissue arises from high-resolution 3D spatial positioning of self-assembling structures, angiogenic factors and relevant cell lineages, reprogrammed and expanded in a dedicated bioreactor under controlled conditions. Our long-term vision encompasses (1) the establishment of a Tissue Engineering industry for personalized organ repair, producing any type of well vascularized and fully functioning tissues and (2) the maintenance of such tissues alive for long periods of time, for an easy transportation to hospitals and clinics, even far from the big cities. THOR will foster the rise of a new industry and of a new biomedical field, while cadaveric donors' transplants will not be necessary.

Keywords: vascular,biohybrid,biofunctionalization,stem cells,human,loom,spider,organoculture,3d substitutes,in vitro,self assembly
Making the Franks: European Immigration and Citizenship in the Pre-Modern Ottoman Empire. (MAKEFRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 132638.4
EU funding (EUR): 132638.4
Participants: 1
Project status: SIGNED

This project explores the creation of norms on citizenship and naturalization in the pre-nineteenth-century Ottoman Empire. It focuses on European mercantile communities in three cities-Istanbul, Aleppo, and Izmir in the seventeenth and eighteenth centuries and on jurisdictional disputes between Ottoman and European officials over the legal belonging of European immigrants. Since that, before the nineteenth-century, a territorial-based notion of citizenship and universal identification systems did not exist in Europe and the Ottoman Empire, the political affiliation of European merchants and other immigration was often a matter of local controversy and diplomatic negotiations. These episodes of crisis, MAKEFRA argues, lead to the elaboration of internationally-recognized rules and practices over legal belonging, a “proto-citizenship” for European and Ottoman subjects. These rules, jointly elaborated by European and non-European actors, constituted the basis for modern-day systems of citizenship and naturalization in Europe and the Middle East.

Keywords: citizenship,ottoman empire,immigration,early modern period,international law
Angelo Clareno (ca. 1260-1337) as a marginal Translator of the Greek Fathers : Circulation of Texts and People in Europe before Humanism (TRANSMAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-15
End date: 2025-11-14
Duration (months): 30.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

TRANSMAR aims to provide innovative perspectives and knowledge on the introduction, appropriation and circulation of the thought and texts of the Eastern Fathers in the West before Humanism and contribute to break the myth of the medieval ignorance of Greek. The project focuses on one marginal and emblematic translator, the Italian Franciscan dissident Angelo Clareno (ca. 1260-1337), best known as leader of the so-called fraticelli, persecuted all his life by the ecclesiastic authorities, and several Greek patristic texts that were first translated into Latin between the late 13th and early 14th centuries. Some of these, which have a long lasting influence on Western Christian spirituality until the Renaissance, were translated by Clareno himself, especially during his forced exile in Armenia and Greece. The others are attributed to him. By establishing and analysing the manuscript tradition of each of these translations TRANSMAR’s purpose is to understand how these Eastern patristic texts were introduced in the West for the first time and to evaluate their socio-cultural impact. By studying how and by which networks texts translated by a representative of a minority religious group spread, the project also aims to reflect on the social function of minorities in the long term. Based on a resolutely interdisciplinary approach, at the intersection of philology, manuscript studies, history of religion and spirituality, history of dissent/minorities, medieval translation, TRANSMAR is intended to determine the texts actually translated by Clareno, to investigate the circumstances of their composition, to map their circulation in Europe and to identify the networks through which they circulated.

Keywords: latin philology,byzantine philology,medieval translation,manuscript culture,history of dissidence,history of religion and spirituality
Deconstructing and Rewiring RNA-RBP regulatory networks (RBP-ReguNet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,France,Italy,United Kingdom,Germany,Netherlands
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2714988.34
EU funding (EUR): 2603800.8
Participants: 15
Project status: SIGNED

RNA-binding proteins (RBPs) are critical regulators of gene expression programs. They regulate all aspects of RNA life, including transcription, splicing, modification, localization, stability, translation and decay, and consequently, perturbations in these RBP-RNA networks underlie the origin of many diseases. Recent proteomics-based studies have vastly expanded the repertoire of RBPs to the thousands, uncovering unconventional RBPs such as metabolic enzymes ‘moonlighting’ in RNA-binding activity or RNAs “riboregulating” protein function. This represents a much broader layer of biological control that was previously envisaged, which adds an entirely new dimension to RBP-dependent regulation of cellular homeostasis. RBP-ReguNet has been conceived to leverage these new discoveries to identify druggable targets for a range of untreatable diseases, including cancer, neurological disorders, liver diseases and infectious disease. Our ambition in RBP-ReguNet is to create a high-level training program based on basic research but with a strong impact on clinical translation. RBP-ReguNet will provide advanced multidisciplinary scientific training that spans from computational, structural, molecular and cellular biology to medicinal chemistry and pharmacological screening, to the next generation of European researchers in an intersectoral environment to pursue ambitious and high gain research on the development of new therapies based on RBP biology. They will be trained in a range of core and state-of-the-art discipline-specific research skills, complementary transferable skills, and entrepreneurial skills by secondments to non-academic partners, with a common focus to discover actionable targets. This network of excellence will push the boundaries of knowledge in the protein-RNA interactions universe, and at the same time provide the next generation of students with the skills to become future leaders in the field.

Keywords: rna binding proteins,cancer,drug discovery,proteomics
CryoEM@NOVA: a cryo electron microscopy hub enabling drug discovery (CryoEMatNOVA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500743.75
EU funding (EUR): 2500743.75
Participants: 1
Project status: SIGNED

Structural biology is essential for atomic-level understanding of structure-function relationships in living systems and increasingly key to providing knowledge structure-based drug discovery. While traditionally the method of choice has been x-ray crystallography, in the past seven years, dramatic improvements of resolution using cryo electron microscopy (cryo-EM) have resulted in cryo-EM named 2015 Nature Method of the Year and the 2017 Nobel Prize in Chemistry. This in turn has had a major impact on the number of cryo-EM installations in Europe, publicly deposited structures, publications and related knowledge, teaching and dissemination. Portugal is one of the few European countries without this technology. That is now changing with the inclusion of cryo-EM in the Portuguese Roadmap of Research Infrastructures 2020, resulting in major funding (€2.5M) for the first autoloader cryo electron microscope to be installed in Portugal in 2022, coordinated by the CryoEM-PT consortium in whichNOVA is a node. This presents an excellent opportunity for establishing cryo-EM research and training in Portugal, and specifically at NOVA, which has expertise using x-ray crystallography and NMR, while expertise in cryo-EM is lacking, resulting in unmet needs. The overall objective of CryoEM@NOVA is to establish a sustainable cryo-EM hub for research and training at NOVA. Under the direction of the ERA Chair holder this objective is clearly achievable as Prof. Luecke has experience in setting up cryo-EM infrastructure leading to high-resolution structures of proteins with medically-relevant bound inhibitors, generating high-impact publications and attracting funding and collaborations. The operation of advanced electron microscopes and associated vitrification robots coupled with storage- & compute-intensive data analysis requires scientists with in-depth knowledge & training. Such talent will have acquired this expertise elsewhere and will need to be recruited to Portugal.

Keywords: cryo electron microscopy cryo electron tomography micro electron diffraction life sciences helicobacter pylori drug discovery
Eavesdropping on bacterial gossip in biofilms for resource recovery from wastewater (BIORESCue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

BIORESCue delves into the role of bacterial quorum sensing, a cell-to-cell communication in wastewater biofilms. The hypothesis posits that quorum sensing holds a key role to understanding biofilm formation, and that introducing exogenous quorum sensing signaling molecules in high-rate activated sludge biofilms has the potential to enhance biopolymer production and bioflocculation. As the global water community increasingly recognizes the untapped potential of wastewater as a resource for green energy and biopolymer, this project aims to address a significant knowledge gap in the field. I will develop advanced bioanalytical techniques combining bioassays with chemical screening to explore uncharted diversity, concentration, and activity of signaling molecules in wastewater biofilms. I will explore the dose-effect relationship of signaling molecules in high-rate activated sludge, to offer practical strategies for optimizing resource recovery. By combining this unique dataset with a detailed analysis of bioflocculation and biopolymer composition, I seek to uncover valuable insights on the role and effects of quorum sensing in biofilms. Implemented at the Aarhus University and the host research group, this project will allow me to enhance scientific, communication and project management skills, through a well-designed training program (courses, workshops, regular meeting with supervisors), as well as measures for knowledge exchange and dissemination. Aligned with UN Sustainable Development Goals, particularly in the interests of clean water, affordable energy, and sustainable industries, this project has the potential to revolutionize wastewater treatment, transforming treatment plants into net energy producers and fostering sustainable resource recovery, thus addressing pressing global challenges while advancing scientific understanding and innovation in wastewater treatment.

Keywords: environmental biotechnology quorum sensing resource recovery wastewater treatment technology energy recovery biopolymers
A circuit perspective on olfaction – how learning and context shape the propagation of information between brain areas (olfACTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Sensory information is initially processed in specialized brain areas but only integration with previously acquired knowledge provides meaningful information for flexible action selection. This requires the propagation of information from sensory to association areas, where sensory information is put into context and memories are acquired. The entorhinal-hippocampal network is of particular importance for information integration and memory formation. Recent findings about learning-induced changes in sensory areas raise the question whether they occur independently or reflect altered top-down influence of the abundant feedback projections from associative areas. While learning- and context-related changes of activity have been described for individual brain areas, it is largely unknown how learning affects propagation of information between areas. The proposed project aims to dissect the mechanisms by which learning and context shape propagation of sensory information from the olfactory system to the entorhinal-hippocampal network in mice. Olfaction provides unique features to address this aim: a short pathway from sensory to association areas, a discrete time frame for information sampling by respiration, and the capability of mice to quickly learn odor-guided tasks. The main hypothesis of this project is that timing and synchrony of neuronal activity are key parameters in determining the propagation of information between brain areas and that they are affected by learning and context through feedback projections from association areas. This hypothesis will be tested by simultaneous electrophysiological recordings in olfactory bulb, piriform cortex, lateral entorhinal cortex, and hippocampus during learning of odor-reward associations, combined with optogenetic manipulations and anatomical assessment of connectivity between these areas. This project will reveal the mechanisms by which learning- and context change the propagation of information between brain areas.

Keywords: population activity,large scale networks,synchrony,olfaction,entorhinal cortex,hippocampus
METABOLic immuno-engineered biomATErials (METABOLATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-21
End date: 2025-07-20
Duration (months): 27.0
Total project cost (EUR): 242476.2
EU funding (EUR): 242476.2
Participants: 3
Project status: CLOSED

Large bone defects display compromised healing associated with pronounced inflammation and constitute a major clinical problem. Recently, a range of novel biomaterial-based approaches have been engineered to promote bone regeneration. However, once these constructs are implanted, they encounter the harsh environment of damaged tissue and often fail to induce a regenerative response. With this MSCA Post-Doctoral Fellowship, I will address the clinical problem of large bone defect repair by harnessing extracellular vesicles (EVs) derived from metabolically modulated macrophages to promote the immunogenic, angiogenic, and osteogenic response in the long-term healing cascade. Specifically, my research goal is to generate an immuno-engineered scaffold with these multitargeted regenerative EVs to maximise bone repair. The proposed multidisciplinary project will be carried out in the Tissue Engineering Research Group (TERG) at the Royal College of Surgeons in Ireland (RCSI), which is a leading partner in the Science Foundation Ireland (SFI) funded Advanced Materials and BioEngineering Research Centre (AMBER) under the supervision of Prof. Annie Curtis. Additionally, as part of my project training plan, I will carry out a secondment in Trinity College Dublin, under the supervision of Prof. David Hoey, gaining expertise in materials for bone regeneration. At the end of the fellowship, with my non-academic placement at TAmiRNA, a biotech company specialising in diagnostic and therapeutic miRNAs, I will investigate the small RNA-cargo of the pro-regenerative EVs for the identification of new specific therapeutic targets. METABOLATE is a unique opportunity to acquire advanced research competencies and complementary skills through interdisciplinary and inter-sectoral training. This will allow me to mature as an independent scientist and to enrich my professional profile, preparing me for a multitude of career choices.

Keywords: immunomodulatory biomaterials,bone regeneration,extracellular vesicles,immunoengineering,macrophage metabolism