Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brainstem circuit ensembles for movement flexibility (ensembles)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Movement is the shared language of behavior across the animal kingdom, orchestrated by dedicated circuits throughout the central nervous system. To survive, animals must move with a high degree of flexibility, requiring precise and rapid changes in speed and trajectory. This flexibility of locomotion depends on the brain's ability to select appropriate motor programs and coordinate body and appendage muscles to match the locomotor movement parameters to the behavioral context. In particular, the brainstem has been identified as the major site for shaping motor commands to provide this flexibility. A key, unsolved question is how the final brainstem commands are generated and adjusted. In this project, we will test a new hypothesis that challenges current views in motor control, namely that the final motor commands driving the flexibility of locomotion movements are the combined product of precise interactions between circuit ensembles in the brainstem and real-time feedback from the spinal circuits. Our approach harnesses the powerful combination of all-optical techniques, scRNAseq, and electrophysiology at single-neuron resolution to determine the principles of circuit integration within and across brainstem circuits in adult zebrafish. This innovative approach will allow us to uncover circuit function, at a level of resolution that has never been achieved before, in a behaving vertebrate animal. By performing a system-wide analysis at single-cell resolution, we expect to gain unique insights that will transform existing views in the field of motor control. This project will chart a novel, system-wide circuit blueprint for movement control and flexibility in vertebrates.

Keywords: brainstem,spinal cord,locomotion,motoneurons,motor control
Beyond Renormalization in Parabolic Dynamics (BRen)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2183838.0
EU funding (EUR): 2183838.0
Participants: 1
Project status: SIGNED

The ergodic theory of parabolic dynamical systems is an area in smooth ergodic theory that is relevant for its connections to mathematical physics and to analytic number theory. A dynamical system is parabolic whenever its orbits diverge at an intermediate (often polynomial) rate between bounded/logarithmic (called elliptic) and exponential (called hyperbolic) rate. The proposal tackles several outstanding questions in the ergodic theory of parabolic flows with emphasis on quantitative aspects. The main goal is to go beyond renormalization techniques that have proved extremely powerful in several classes of examples: Interval Exchange Transformations and Flows on surfaces, horocycle flows, nilflows on quotients of step-two nilpotent groups and Gauss sums. Renormalization methods are not available in other equally fundamental examples of similar nature: billiards in non-rational polygons, higher step nilflows and non-horospherical unipotent flows in homogeneous dynamics. A unified approach to effective ergodicity is proposed that encompasses all of the above mentioned examples. Outstanding questions include ergodicity and existence of periodic orbits of non-rational billiards in polygons, effective ergodicity of higher step nilflows with optimal deviation exponents and applications to bounds on Weyl sums for higher degree polynomials and effective ergodicity of non-horospherical unipotent flows on semi-simple finite-volume quotients. The analytical foundations of the method lie in the study of invariant distributions for parabolic flows. In the examples considered the analysis can be carried out by methods of non-Abelian Fourier analysis (theory of unitary representations). In general, for non-homogeneous parabolic flows, all questions concerning invariant distributions and their relevance for smooth ergodic theory are wide open. Several problems to probe the question of existence of invariant distributions are proposed.

Keywords: effective ergodic theory of parabolic flows dynamics of billiards in polygons bounds on weyl sums invariant distributions and cohomological equations
Science Goes To School (SCIENCE GTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-03-01
End date: 2023-12-31
Duration (months): 22.0
Total project cost (EUR): 334467.46
EU funding (EUR): 296157.46
Participants: 10
Project status: CLOSED

The Mediterranean regions of Murcia and the Valencian Community share the same sea and horizon. A symbol of a collective future with great common environmental, technological, economic and social challenges. The contributions of bi-regional R+D+i are necessary to face these challenges, as well as it is necessary to ensure their continuity. Children and young people need to have a positive image of R+D+i, feel identified with it through inclusive and balanced gender referents and know the possibilities of STEAM (Science, Technology, Engineering, Arts and Mathematics) and research careers. Society also needs critical citizens without extreme positions not based on evidence that can weaken civic awareness and trust in democratic institutions. The main objective of Science Goes To School (SCIENCE GTS) is to implement a robust program of activities that brings research closer to society and vice versa. For this, it will use multiple informative formats (talks, workshops, shows, contests ...) and methodological resources (entertainment, humour, surprise ...). The topics covered will be both the great challenges posed by the Horizon Program, the Sustainable Development Goals and the European Green Deal, as well as the science of daily life. SCIENCE GTS contemplates two major actions: Researchers at Schools (RaS) and European Researchers' Night (ERN). RaS encourages the interaction of researchers and students, emphasizing the stimulation of scientific vocations, gender equality and inclusiveness. ERN makes researchers and general public interact, focusing on critical thinking, scientific culture and citizen science. A realistic awareness campaign will be used to secure the audience and a solvent assessment to measure the outreaches and impacts. The project is managed and coordinated by a neutral partner, who pursues the creation of a collaborative infrastructure between project partners and stakeholders that avoids duplication of effort.

Keywords: mediterranean science,researchers students citizens interactions,eu missions,sustainable development goals,european green deal,daily science,steam vocations,gender gap,inclusion,critical thinking
AIR-BASED SOLAR THERMAL ELECTRICITY FOR EFFICIENT RENEWABLE ENERGY INTEGRATION & COMPRESSED AIR ENERGY STORAGE (ASTERIx-CAESar)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Germany,Greece,Switzerland,United Kingdom,Czechia,Italy,Austria,Denmark,Belgium
Call: Innovative components and/or sub-systems for CSP plants and/or concentrating solar thermal installations (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 5887597.5
EU funding (EUR): 5270925.38
Participants: 17
Project status: SIGNED

Highly efficient energy conversion of solar power and storage will play a vital role in a future sustainable energy system. Thus, this project focuses on the development of a novel high-efficiency solar thermal power plant concept with an integrated electricity storage solution. The project combines air-based central receiver Concentrated Solar Power (CSP) and Compressed Air Energy Storage (CAES) to maximize conversion efficiency and power grid energy management, enabling a new operation strategy and business models. The hybrid concept initiates a futuristic era with adaptive renewable power plants, producing both electrical and thermal energy, including process heat supply and reverse osmosis desalination. Because cheap off-peak electricity is used to provide the air compression work of the topping Brayton cycle, the overall peak solar-to-electric energy conversion efficiency of the proposed power plant may reach up to 40% efficiency, which roughly doubles the peak efficiency with respect to state-of-the-art CSP technology. The project’s activity will cover the techno-economic-environmental optimisation of the innovative CSP-CAES plant using representative boundary conditions, provided by grid operators and specialised partners, as well as the development and extensive testing of key components needed for its implementation. The main development will cover: (i) an advanced high-efficiency solar receiver, (ii) optical sensors and AI-based control, (iii) optimized CAES with heat exchangers and compressor/expander detailed designs and (iv) innovative integration of desalination. The proposed technology is set forth by an interdisciplinary partnership spanning the entire CSP value chain. Targeting a TRL of 6-7, the ASTERIx-CAESar concept will be validated with a demonstration scale of 480 kWth prototype in a relevant environment.

Keywords: electricity storage concentrated solar power compressed air energy storage volumetric solar receiver caes csp
3D Decision Support Tool for Brain Tumor Surgery (STRATUM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Spain,Germany,Netherlands,Sweden,France,Italy
Call: Harnessing the potential of real-time data analysis and secure Point-of-Care computing for the benefit of person-centred health and care delivery (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 10714691.25
EU funding (EUR): 9990566.25
Participants: 13
Project status: SIGNED

Integrated digital diagnostics can support complex surgeries in many anatomies where brain tumour surgery is one of the most complex cases. Neurosurgeons face several challenges during brain tumour surgeries, such as critical tissue and brain tumour margins differentiation or the interpretation of large amount of data available provided by several independent devices. To overcome these challenges, STRATUM will develop a 3D Decision Support Tool for brain surgery guidance and diagnostics (reaching TRL7) based on multimodal data processing through Artificial Intelligence (AI) algorithms that will be integrated as an energy-efficient Point-of-Care computing tool. It will be developed following a co-creation methodology involving key stakeholders and end-users. STRATUM will pursue the following objectives: 1) To foster advances in personalized medicine based on multimodal data (including the emerging hyperspectral imaging modality) and AI. 2) To increase the intraoperative diagnostic accuracy of brain tumours, improving surgical outcomes and patients’ quality of life. 3) To reduce surgery time with respect to current neurosurgical operation durations. 4) To improve current cost- and energy-efficiency of neurosurgical workflows. 5) To demonstrate the prototype in a two-year clinical study in 3 clinical sites, including an early health technology assessment. 6) To prepare the preliminary business plan and the TRL9 roadmap after the project ending. An optimized integration and processing of available and new emerging data sources would aid surgeons in timely efficient and correct decision-making in tissue removal. This would maximize the degree of resection while simultaneously minimize the risk of neurological deficits. Moreover, time efficient surgical procedures not only benefit the patients directly by minimizing anaesthesia time and risks of e.g. postoperative infections, but also indirectly by optimizing resources of the health care system.

Keywords: multimodal imaging hyperspectral imaging artificial intelligence brain cancer personalized surgery neurosurgery decision support tools point of care computing
Exploration of targeting GPR56 and its cancer cell ligand as a novel immune checkpoint inhibition strategy (GPR-ICI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy over the last decade. In essence, ICIs block the interaction of immunosuppressive receptors and their ligands, which attenuate T cell activity and the secretion of pro-inflammatory cytokines. Blocking these inhibitory signals results in the release of immunosuppression and promotes anti-tumor T cell reactivity. Unpublished data from our research group, emerging in collaboration with the biotech company InProTher suggests a novel immune checkpoint receptor-ligand pair consisting of an adhesion G protein-coupled receptor (GPCR) and a viral protein. With therapeutic targeting of GPCRs being our main focus, we - together with our collaboration partner InProTher - aim to investigate the blockade of the interaction between immune cells expressing the adhesion GPCR and cancer cells expressing the viral protein as novel ICI and cancer therapy strategy. The exploration of novel immune checkpoints and expanding the repertoire of cancer therapy drugs are paramount for overcoming therapeutic resistance and advancing cancer treatment.
Proteome diversification in evolution (PROMISE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1952762.5
EU funding (EUR): 1952762.5
Participants: 1
Project status: SIGNED

Proteins are essential and incredibly versatile actors for all biological processes in living organisms. Massive amounts of data describing their amino acid sequences and 3D shapes are now openly accessible. Yet, we still know little about how they interact and function with one another in vivo. Nor how they diversified throughout evolution to orchestrate highly specialised behavioural traits. This ERC CoG proposal, PROMISE, meets the urgent need for decrypting protein sequences and structures toward guiding biological intervention. It will assess and harness the protein variations naturally occurring in multi-cellular organisms to unlock critical questions across developmental, evolutionary, and molecular biology: - What are the sites in a protein crucial for selecting its cellular partners and binding to them? How can they be modified toward modulating protein functioning? - How did the proteomes responsible for the ability of humans and zebra finches to learn "language" from their peers expand in evolution? Are there convergent amino acid patterns, beyond the striking analogies in the underlying anatomical structures and in gene expression and regulation? PROMISE will leverage the tension between evolutionary divergence, gene duplication, and alternative splicing by combining massive high-throughput protein-related data integration and cutting-edge artificial intelligence techniques. It will bring a paradigm shift on assessing protein diversity and its impact on rewiring interaction networks in evolution. The expected results will provide efficient and scalable solutions to extract biological meaning from big data and transform it into interpretable and actionable models. This new knowledge will be transferable to a broad range of impactful societal issues, such as the inter-individual variability in disease susceptibility, the design of more specific drugs and more bio-compatible de novo proteins, or strategising human adaptation to climate change.

Keywords: protein evolution,alternative splicing,proteome diversity,representation learning,deep learning,bioinformatics,computational biology,genomics,transcriptomics,proteomics,molecular modelling,protein design,comparative biology,vocal learning
Middlebrow Modernity: Irish Writers and The New Yorker in the Mid-Twentieth Century (IWandTNYinMID20thC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: CLOSED

This project explores Irish writers’ connections with The New Yorker, shedding new light on the literary transactions between the US and Ireland in the mid-twentieth century. I investigate how Irish writers engaged with the American metropolitan magazine’s post-war liberalism; I also consider the extent to which the connection with TNY can help us redefine Ireland’s “isolated” literary environment in relation to global modernity. Many important Irish writers contributed regularly to TNY. While it is well known that the magazine enhanced Irish writers’ international standings, some critics have voiced concerns that the magazine’s scrupulous editorial process limited the writers’ experimentalism and capitalized upon their stories’ Irishness in order to appeal to a largely American readership. This criticism, however, risks overstating the popular magazine’s supposed “conservatism.” As a middlebrow publication that aimed to inform and entertain at the same time, TNY navigated the liminal—yet richly evocative—space between highbrow culture and lowbrow humour, revealing an ambivalent attitude towards both radical reforms and middleclass complacency. Drawing on periodical studies and theories of middlebrow culture to establish my theoretical framework, I consider this metropolitan magazine’s fraught relationships with the experimental arts and its intimate involvement in the experience of modernity. I argue that it was not TNY’s “conservatism,” but its ambivalences towards modernity that resonated with mid-twentieth-century Irish writers. Re-inserting the fictional works of the Irish writers into the textual space of TNY—alongside the cartoons, advertisements, and journalistic reports—this project advances our understanding of the Irish short story in relation to metropolitan and transatlantic modernity. It offers the first fully contextualized literary–biographical account of the relationships between the TNY editors, the Irish writers, and their American peers.

Keywords: modern irish literature,the new yorker,middlebrow,periodical studies,the new modernist studies
European Partnership for Personalised Medicine (EP PerMed)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: COFUND actions
Partnership: Personalised Medicine (co-funded)
Countries involved: Germany,France,Belgium,Spain,Italy,Norway,Austria,Ireland,Lithuania,Israel,Estonia,Türkiye,Sweden,Poland,Portugal,Netherlands,Luxembourg,Finland,Denmark,Hungary,Latvia,Iceland,Romania,Greece,Czechia,South Africa,Slovakia,Canada
Call: European Partnership on Personalised Medicine (HORIZON-HLTH-2023-CARE-08, 2023)
Start date: 2023-11-01
End date: 2033-10-31
Duration (months): 120.0
Total project cost (EUR): 340681048.31
EU funding (EUR): 100575465.38
Participants: 63
Project status: SIGNED

EP PerMed is a new European Partnership dedicated to Personalised Medicine (PM). It supports PM-related R&I, but also facilitates and accelerates all steps so that PM achievements successfully pass through the full value continuum to be implemented in sustainable health systems for the benefit of people and societies. The partnership will foster demonstration projects and promote successes and lessons learned to demonstrate evidence of PM implementation. EP PerMed activities cover overarching aspects, like patient involvement, exchange with medical societies, infrastructures and international and regional collaboration. The project portfolios of EP PerMed and ERA PerMed (ERA-Net co-fund on PM) and others are supported to become successful innovations in healthcare practice. EP PerMed will be the global PM-platform for scientific and strategic dialogue and alignment, resulting in public documents and publications. Accordingly, it will inform the public, patients, healthcare providers or payers about the latest PM options and engage them. The Strategic Research and Innovation Agenda for Personalised Medicine (SRIA for PM, 2023), developed by EP PerMed partners, is the basis for the partnership's structure and a wide range of its activities. All steps of the SRIA development were strongly support by numerous PM-experts, stakeholders and the European Commission (EC). Thus, the EP PerMed annual Joint Transnational Calls (JTCs) and other funding and activities, events and tools will be in line with the SRIA and outputs will feed into a SRIA update in the coming years. The partnership builds on several developments, initiatives and projects such as ERA PerMed, ICPerMed and its supporting projects (“ICPerMed Family”) funded by the EC. In parallel, it reaches out to the 1+Million Genomes Initiative, other European Partnerships in the Health Cluster and infrastructures like the European Strategy Forum on Research Infrastructures (ESFRI).

Keywords: research,innovation,implementation,transnational,value chain