Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION (PhytoAPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Azerbaijan,Ukraine,Slovakia,Belarus,Russian Federation,Netherlands,Denmark,United Kingdom,Kazakhstan,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 883200.0
EU funding (EUR): 883200.0
Participants: 12
Project status: SIGNED

Under PhytoAPP project it is expected to build new and enhance existing network of international and inter-sectoral cooperation in the form of joint research and innovation activities between the project Partners with multidisciplinary skills and complementary competences in nanomaterials, physics, engineering, green chemistry, biochemistry and medical science. It will significantly strengthen the interaction between academic and non-academic sectors within MS/AC Countries Portugal, Netherlands, Denmark, Slovak Republic, Ukraine and Third Country Kazakhstan, in the field of the innovative phytoproducts application for the health and well-being. The main objectives of the PHYTOAPP project are design, development and delivery of the innovative water-soluble Phytochemical Inhibitors for Alzheimer and Parkinson diseases prevention. To achieve this goal the PHYTOAPP project will explore the innovative nanotechnological solutions to overcome phytochemicals limitation faced by their low water-solubility via fullerene-enhanced innovative synthesis of water-soluble green Phytocomplexes, by means of cooperation between Researchers and SMEs Partners from EU and Partner’s Countries. On the other hand, the involved parties are eager to promote innovation in this area in accordance with the provisions of the Treaty establishing the European Economic Community which seek to strengthen the scientific and technological basis of Community industry and encourage it to “become more competitive at the international level”

Keywords: nanomaterials,materials design,phytochemicals,kinetics,amyloid fibrils,bioactivity,toxicity,in vitro,testing,in vivo testing
Borealis – the 3A energy class Flexible Machine for the new Additive and Subtractive Manufacturing on next generation of complex 3D metal parts. (BOREALIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Germany,Spain,Switzerland,Greece,Netherlands,United Kingdom
Call: Manufacturing processes for complex structures and geometries with efficient use of material (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 7986625.01
EU funding (EUR): 5968875.0
Participants: 18
Project status: CLOSED

Borealis project presents an advanced concept of machine for powder deposition additive manufacturing and ablation processes that integrates 5 AM technologies in a unique solution. The machine is characterized by a redundant structures constituted by a large portal and a small PKM enabling the covering of a large range of working cube and a pattern of ejective nozzles and hybrid laser source targeting a deposition rate of 2000cm3/h with 30 sec set-up times. The machine is enriched with a software infrastructure which enable a persistent monitoring and in line adaptation of the process with zero scraps along with number of energy and resource efficiency optimization policies and harvesting systems which make the proposed solution the less environmental invasive in the current market. Borealis idea results from a consortium composed by the excellence of developers of worldwide recognized laser machines and advanced material processing together with the highly precision and flexible mechatronic designers. These two big clusters decided to join their expertise and focus on new manufacturing challenges coming from complex product machining in the field of aerospace, medtech and automotive represented by major partners in the market. Borealis project targets a TRL 6 and will provide as outcome of three years work two complete Borealis machine in two dimensions – a lab scale machine and a full size machine – which are foreseen to be translated into industrial solution by 2019.

Keywords: additive manufacturing,ablation,energy efficient machines,areospace,automotive,med tech
Sightless touch infotainment system for drivers (Sightless Touch)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Israel
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sightless Touch by Inpris, an auto technology that for the first time enables eyes-free touch control for automotive infotainment systems, making driving safe again, without compromising on connectivity and efficiency. Sightless Touch can also increase the efficiency of voice recognition systems, since the system already knows what kind of commands it should receive next, simply use different fingers to fluidly substitute voice actions, skipping many time consuming layers of verbal clarification; therefore, reducing potential errors and driver distraction. Current systems in vehicles offer limited solutions and most are based either on traditional touch screen, which requires the driver to look at the screen while driving, or on voice commands, which according to AAA, cause cognitive distraction and are slow and unreliable. Sighless Touch is a futuristic methodology that maps the human hand and follows the fingers through algorithms assigning a different function for each finger and its movements opening the possibility for commands to operate a console without looking at it. We thus present Sightless Touch as a safer, faster y more reliable technology that is the future, today, in your hands. Sightless Touch not only does it free the driver’s eyes from looking at the screen, but it is 10 times faster, and prevents the cognitive distractions that traditional systems cause. Sightless Touch expects to reach 3 million units by 2023. The product will render revenues of around €36 million and a profit of €19.4 million that year. We estimate funding needs a further 1.5 million to launch the product suite to market, and a ROI of 31 by 2023 and payback in the first half of 2020.

Keywords: sighless touch system,car infotainment
Hydrogen Mobility Europe (H2ME)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Austria,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Italy,Germany,Iceland,Belgium,Norway,Belgium,Sweden,Sweden,France,France,France,France,France,France,France,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Large scale demonstration of refuelling infrastructure for road vehicles (H2020-JTI-FCH-2014-1, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 62308186.05
EU funding (EUR): 32000000.0
Participants: 41
Project status: CLOSED

Hydrogen Mobility Europe (H2ME) brings together Europe’s 4 most ambitious national initiatives on hydrogen mobility (Germany, Scandinavia, France and the UK). The project will expand their developing networks of HRS and the fleets of fuel cell vehicles (FCEVs) operating on Europe’s roads, to significantly expand the activities in each country and start the creation of a pan-European hydrogen fuelling station network. In creating a project of this scale, the FCH JU will create not only a physical but also a strategic link between the regions that are leading in the deployment of hydrogen. The project will also include ‘observer countries’ (Austria, Belgium and the Netherlands), who will use the learnings from this project to develop their own hydrogen mobility strategies. The project is the most ambitious coordinated hydrogen deployment project attempted in Europe. The scale of this deployment will allow the consortium to: • Trial a large fleet of FCEVs in diverse applications across Europe - 214 OEM FCEVs (Mercedes and Toyota) and 125 fuel cell range-extended vans (Symbio collaborating with Renault) will be deployed • Deploy 29 state of the art refuelling stations, using technology from the full breadth of Europe’s hydrogen refuelling station providers. The scale will ensure that stations will be lower cost than in previous projects and the breadth will ensure that Europe’s hydrogen station developers advance together • Conduct a real world test of 4 national hydrogen mobility strategies and share learnings to support other countries’ strategy development • Analyse the customer attitude to the FCEV proposition, with a focus on attitudes to the fuelling station networks as they evolve in each country • Assess the performance of the refuelling stations and vehicles in order to provide data of a sufficient resolution to allow policy-makers, early adopters and the hydrogen mobility industry to validate the readiness of the technology for full commercial roll-out.

Keywords: fcevs,h2 station network,commercialisation,hydrogen technologies roll out,early adopters,consumer behaviour,next generation
Unraveling huntingtin function in cortical and striatal human development (Huntingtin hPSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Huntington's disease (HD) is a rare neurodegenerative autosomic dominant disorder that causes severe motor dysfunction and cognitive deficits. Although HD main symptoms are manifested at mid-life, increasing evidence suggest that early neurodevelopmental defects may contribute to the late pathology. HD is a monogenetic disorder caused by a CAG repeat expansion inside the huntingtin gene (Htt). The functional role of Htt has been widely studied as a pro-survival anti-apoptotic factor, a regulator of vesicular trafficking along microtubules, a transporter of proteins between nucleus and cytoplasm, and a transcriptional role, however it’s main role in the brain during development and later adulthood is still poorly understood. Recently, genetic mouse models have shown that the loss of huntingtin from the brain at an early stage of development results in mitotic neural progenitor defects that disrupt cell fate in the cortex. In addition, the same study showed that loss-of-function of huntingtin specifically in early born neurons showed neuronal migration and neuronal dendritic arborization defects. However, to date, no studies have addressed and dissected the different roles of the human huntingtin protein in human cortical and striatal development specifically in different cell populations, or the effects of early phenotypes caused by loss-of-function of huntingtin in the late neuronal function. Here, I will study and dissect the function of human huntingtin during human development using human pluripotent stem cells (PSC) differentiated towards cortical and striatal neurons. Through this project I will generate several conditional knock out and full knock out human PSC lines to remove Htt expression specifically from different neuronal cell populations. Overall, all these analyses will give an overview of the developmental changes occurring in the absence of Htt function during cortical and striatal differentiation and neuronal maturation.

Keywords: human pluripotent stem cells,3d neuronal differentiation from hpsc,huntingtin function,crispr,cas9 mediated htt conditional ko generation,huntington s disease
Searching for new physics with liquid argon time projection chambers and developing the technology for the future of neutrino physics (LARNUEXP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-06-01
End date: 2021-05-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

The field of neutrino physics is an exciting one to be involved in at the moment. Neutrinos are the most mysterious fundamental, interacting so weakly with other matter that they are elusive to measurements. They also offer the only known indicators of physics beyond the Standard Model. I will use this fellowship to build expertise in the technology that will define the future of the field of neutrino physics - the liquid argon time projection chamber (LAr-TPC). I will spend the outgoing phase at Fermilab, USA, installing and commissioning the SBND detector, and working with data from SBND and the existing MicroBooNE detector. I have a track-record of pioneering searches for new physics, and will continue this by searching for a new Z boson that could be an explanation for the g-2 anomaly. I will also capitalise on my involvement in the protoDUNE liquid argon test-beam experiment, taking the protoDUNE data and applying it to the SBND and MicroBooNE detector simulations, to bring a new level of precision to the experiment. I have particular expertise in the reconstruction of low-energy electromagnetic showers. I will combine this expertise with the new protoDUNE data to develop new algorithms to enable MicroBooNE and SBND to investigate the MiniBooNE low-energy excess and search for sterile neutrinos. In the return year, I will bring my expertise in LAr-TPC technology back to the UK, and take a leading role in setting up a major production site for making anode planes for the DUNE far detector.

Keywords: neutrino oscillation detector instrumentation liquid argon time projection chamber
Combinatorics with an analytic structure (CASe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany,Israel,Denmark
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2016-12-01
End date: 2022-05-31
Duration (months): 66.0
Total project cost (EUR): 1337200.0
EU funding (EUR): 917494.4
Participants: 3
Project status: CLOSED

Combinatorics, and its interplay with geometry, has fascinated our ancestors as shown by early stone carvings in the Neolithic period. Modern combinatorics is motivated by the ubiquity of its structures in both pure and applied mathematics. The work of Hochster and Stanley, who realized the relation of enumerative questions to commutative algebra and toric geometry made a vital contribution to the development of this subject. Their work was a central contribution to the classification of face numbers of simple polytopes, and the initial success lead to a wealth of research in which combinatorial problems were translated to algebra and geometry and then solved using deep results such as Saito's hard Lefschetz theorem. As a caveat, this also made branches of combinatorics reliant on algebra and geometry to provide new ideas. In this proposal, I want to reverse this approach and extend our understanding of geometry and algebra guided by combinatorial methods. In this spirit I propose new combinatorial approaches to the interplay of curvature and topology, to isoperimetry, geometric analysis, and intersection theory, to name a few. In addition, while these subjects are interesting by themselves, they are also designed to advance classical topics, for example, the diameter of polyhedra (as in the Hirsch conjecture), arrangement theory (and the study of arrangement complements), Hodge theory (as in Grothendieck's standard conjectures), and realization problems of discrete objects (as in Connes embedding problem for type II factors). This proposal is supported by the review of some already developed tools, such as relative Stanley--Reisner theory (which is equipped to deal with combinatorial isoperimetries), combinatorial Hodge theory (which extends the ``K\"ahler package'' to purely combinatorial settings), and discrete PDEs (which were used to construct counterexamples to old problems in discrete geometry).
Smart farmer’s assistant - iTractor ® (iTractor)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our aim is production start-up and market uptake of our “Hybrid smart robotized electric universal compact tractor- iTractor”.Trademark iTractor®. It is designed to work inside the farmyard or livestock farm."Hybrid" is its navigation – it has two separate systems: -a manual-for the farmer; -a programmable autopilot. Targeted users -the weekend farmers and the owners of organic farms. The problem address: - The types of activities in the small farms are the same as in the big ones, but their volume does not allow specialization of the workers resulting in low labor productivity; - Process automation in agriculture is currently available only for large farms; - the number of agricultural workers in 2014 fell down with 3% from 2013 Business opportunities related to a successful market introduction of ITractor® - Since 2014 the new EU Common Agriculture Policy is greener!Over 100 billion euro will be invested in the agro sector 2014 – 2020. - The new regulations on exhaust emissions of compact agricultural tractors on sale after 1st of October 2017 . The novelty of iTractor® : - iTractor® combines adaptive navigation with visual localization and cloud application for remote control; - The navigation technology of iTractor® is equipped with new sensors and visual vSLAM technology. It is a part of new navigation system with visual localization that allows iTractor to create a precise map of its own limited environment (for now!!) - farm yard; - Using the map, iTractor® works without interruption for four hours or till the completion of its task. Then it drives itself to the charging station for recharging and if necessary it restarts the workflow; - iTractor® plows, lawns or cleans the farm or yard by moving in parallel lines. At the same time it uses the model of adaptive sensors to avoid obstacles; - The smartphone application "Farm App" provides updates on the process of work, advice to farmers and direct connection to the technical support center;

Keywords: smart robotized electrical universal compact farm tractor
Combining carboxylic acid production and fibre recovery as an innovative, cost-effective and sustainable pre-treatment process for heterogeneous bio-waste (CAFIPLA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Spain,Belgium,Belgium,France,France,Portugal
Call: Develop breakthrough technologies to improve the cost-effectiveness and sustainability of pre-treatment steps within biorefining operations (H2020-BBI-JTI-2019, 2019)
Start date: 2020-06-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 4843679.66
EU funding (EUR): 4472099.47
Participants: 14
Project status: SIGNED

The 3-year CAFIPLA project will radically alter the biomass pre-treatment approach for bio-economy applications. Current biomass use comes at a high cost, either in terms of land use (sugar/starch crops) or energy and chemical use (2nd generation biomass). On the other hand, bio-waste is massively produced in urban or rural context but almost not valorised, or solely in low-value applications, in part due to its heterogenous nature. CAFIPLA tackles both issues by developing an integrated biomass valorisation strategy that combines the carboxylic acid and fibre recovery platform (CAP/FRP). CAFIPLA firstly optimises the separation of the easily biodegradable fraction and recalcitrant biomass, as input for the CAP and FRP, respectively. This allows the implementation of tailored valorisation strategies for both routes, which in turn allows the use of heterogeneous biowaste as input, while still ensuring high overall yields. In the CAP, research will focus on process control strategies to obtain specific spectra of carboxylic acids to feed into bioproduction of microbial protein, PHA or caproic acid biooil. In the FRP, fractionation into different fibre ranges will result in intermediates that can be valorised as packaging material or insulation. A TRL5 pilot will demonstrate the CAFIPLA upscaling potential. CAFIPLA represents a radically new approach for bio-economy applications by approaching biomass use more pragmatically. This approach, which centres on the integration of two platforms, allows tailor-made solutions. This improves the sustainability and cost-effectiveness of pre-treatment (ambient pressure/temperature, low chemical use, bio-waste as input material). CAFIPLA will furthermore study the biomass supply chain and the business models for future implementation. The well-balanced consortium, including 7 SMEs on 13 participants, will ensure successful research and impact on the bio-economy well beyond the project consortium and timing.