Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smartness, Health Assessment and Performance Evaluation (SHAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-10-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

I aim to address association of health, wellbeing, smartness and indoor environmental quality (IEQ) with nearly zero energy buildings (nZEBs) in Université catholique de Louvain (UCLouvain, Belgium) under the supervision of Professor Sergio Altomonte. We are living in a decade in which problems such as climate change, global warming, lack of resources, detrimental impact on human health and solutions such as sustainable development, resilient environments, mitigation of carbon emissions, excellence in energy efficiency have never been much more significant before. The Directive 2018/844/ EU amending the Energy Performance of Buildings Directive (EPBD) Directive 2010/31/EU) indicates the requirements for nZEBs. Post-occupancy evaluation (POE) and building performance evaluation (BPE) are significant processes to assess user satisfaction, identify problems in buildings and develop solutions. The main aim of SHAPE project is to propose, deploy, and validate a new BPE tool for healthy and smart nZEBs, tracking holistically and measuring rigorously user comfort, health and well-being, alongside buildings’ energy efficiency and smartness. As the first step of the research methodology, a framework of performance indicators for healthy and smart nZEBs will be created. Secondly, a BPE tool will be developed for assessing health, wellbeing, productivity, IEQ and smartness for new and renovated nZEBs in use. In the third step, the developed BPE tool will be validated in selected existing smart nZEBs. Furthermore, the BPE tool will be finalised in the fourth step and disseminated in the fifth step. In conclusion, the BPE tool will identify problematic areas in nZEBs and recommend improvements for a better building performance with a higher quality for occupants considering human factors. The lessons learned from implementation of the BPE tool can provide guidance for the design of new nZEBs.

Keywords: nearly zero energy buildings nzebs,post occupancy evaluation poe,building performance evaluation bpe,health and well being in the built environment,indoor environmental quality ieq
Quality certification frameworks for Energy Efficiency services to scale up responsible investment in the building sector (QualitEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Spain,Austria,Belgium,Bulgaria,Greece,Slovenia,Slovakia,Belgium,Latvia,Czechia,United Kingdom
Call: Making the energy efficiency market investible (H2020-EE-2016-CSA, 2016)
Start date: 2017-06-01
End date: 2020-06-30
Duration (months): 37.0
Total project cost (EUR): 1603718.75
EU funding (EUR): 1603718.75
Participants: 13
Project status: CLOSED

The QualitEE-project aims to scale up investment in building energy efficiency by establishing quality certification frameworks for energy efficiency services across Europe, which do not exist currently. Quality certification frameworks from other sectors are constituted by the following elements; specification of standardised quality criteria, institutionalisation of the quality assurance process,and active promotion schemes. Quality certification frameworks go beyond the presentation of model contracts,directly addressing the main challenges for energy efficiency markets (EEFIG, 2015): i) Market heterogeneity and lack of standardisation makes it costly for clients to differ between “good quality” and “bad quality” services and lead to customers’ lack of trust; ii) Financial Institutions perceive the “technical risk” of energy efficiency services as opaque and are thus hesitant in making financing decisions; iii) Heterogeneity of services and service providers and lack of standardised project assessment tools restrict bundling of small investments in individual energy services into tradeable bonds,preventing access to secondary capital markets. QualitEE will address these challenges by: - Establishing national promotion teams to form the institutional nucleus for quality certification frameworks; participation of energy efficiency associations, accredited certification bodies, national authorities and financial institutions has been confirmed. - Developing guidelines on EU-wide standardised “technical quality criteria” and “minimum financial information” related to energy efficiency services. - Applying quality criteria and quality certification processes in pilot projects. - Establishing national quality assurance business cases and promotion to ensure market uptake. QualitEE will contribute to market expansion through standardisation and quality assurance of energy efficiency services in an institutional framework that is sustained beyond the end of the project.

Keywords: energy efficiency services,investment,building sector,lack of trust,quality certification frameworks,standardisation,technical quality criteria,financial guidelines,market database
Porous material Analysis Toolbox - Open source (PATO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The objective of the proposal is to advance fundamental science in reactive porous material modeling to foster innovation on the second pillar of the work program "Leadership in Enabling and Industrial Technologies". Starting from the most advanced development done at NASA in the last decade, state-of-the-art reactive porous material models will be improved further with the contribution of expert theoreticians and implemented in a simulation tool released open source. The fundamental developments will be validated and applied to design optimization and process innovation for two industrial applications. The first one is the design of efficient and optimized thermal protection systems for space exploration vehicles (subprogram "space").The second one targets bio-hydrocarbon and bio-carbon production from lignocellulosic biomass. The biomass pyrolysis process will be studied from the wood-cell scale to the process level. The goal is to develop advanced predictive engineering tools to enable process optimization and guide innovation in progress. This second effort will eventually benefit to two "Societal Challenges" of the work program: "Energy" and "Climate action, environment, resource efficiency, and raw materials".

Keywords: thermal protection systems,ablation,pyrolysis,biomass
Heating triggered drug release from nanometric inorganic-metal organic framework composites (HeatNMof)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Italy,Spain,Spain,Belgium,France,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-08-31
Duration (months): 54.0
Total project cost (EUR): 3139370.82
EU funding (EUR): 3139370.82
Participants: 10
Project status: SIGNED

Although recent advances in nanotechnology have provided an excellent platform to revolutionize the domain of health, the efficient and target delivery of many potent drugs in the body still remains an important challenge due to important drawbacks either from the drug (bioavailability, toxicity, etc.) and/or from the nanocarrier (biocompatibility, reproducibility, insufficient targeting). Consequently, there is currently a real demand for drug nanocarriers able to solve these matters for the different administration routes. HeatNMof project aims to develop smart multifunctional nanocarriers of challenging antitumoral drugs based on versatile highly porous biocompatible nanometric Metal Organic Frameworks, associated with exceptional drug payloads and controlled releases, and photo- and/or magnetic inorganic nanoparticles, providing both a specific control of reactions inside living entities (i.e. heating-triggered drug release) and additional properties such as imaging (magnetic resonance, thermal or optoacoustic imaging) and/ or hyperthermia therapy. The successful development of this project, involving academic and industrial partners, will contribute to the improvement of the highly societal relevant cancer therapy. This research objective is strongly related with the prime training/networking aim of HeatNMof: to train the next generation of materials scientists in a highly interdisciplinary and intersectorial research environment, such that they can soundly address upcoming challenges concerning nanomedicine, from the development, optimization and (physicochemical and biological) characterization of inorganic and hybrid materials, as well as their interaction with living entities, with a strong focus on drug delivery platforms based on nanomaterials. HeatNMof will train the next generation of material scientists with sound expertise in nanomedicine, highly needed to bring advanced materials as proposed from the bench to society.

Keywords: plasmonic nanoparticles,magnetic nanoparticles,metal organic frameworks,drug delivery
Modelling the formation of a gordian knot in Human Ubiquitin Hydrolase (GOKNOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The folding of knotted proteins is a challenging research topic of great biophysical interest. In this field, computer simulations have greatly contributed to advance our comprehension of the mechanisms that allow a polypeptide to form a knot during the folding. However, due to limitations in methods and resources, the state-of-the-art picture on the process is still incomplete, and mostly limited to the simplest nontrivial topology, the trefoil knot. In this Action I will investigate the folding of human Ubiquitin C-terminal Hydrolase, whose backbone forms a Gordian knot with five crossings. I will make use of a multi-scale Molecular Dynamics strategy that combines coarse grained and all-atom models with enhanced sampling. Using a coarse grained model I will outline a general picture of the folding, devising the preferential pathways and intermediate states. Then, building on this knowledge, I will employ a full-atom representation of the system, targeting the calculations in the most relevant region of the protein's free energy landscape. The effect of an explicit solvent description will be considered as well. The computational time limitations will be lifted by enhancing the sampling through the use of Metadynamics and Variationally Enhanced Sampling. The Action relies on my experience in enhanced sampling methods, that will be complemented by the training and expertise provided by the host institution, a leading center in coarse-grained modeling of bio-polymers and soft matter. In the course of the action I will establish two key collaborations, providing further expertise for the success of my simulations, and allowing the validation of my theoretical model with experiments. The output of the project will generalize the current picture on knotted protein folding, introducing important methodological advancements, and contributing to the knowledge on a system of great biomedical interest, connected to diseases such as Parkinson's and Alzheimer's.

Keywords: knotted protein folding,polymer topology,coarse grained molecular modeling,enhanced sampling,macromolecules
Sustainable mechanochemical synthesis of nanomaterials from biomass (ENBIOMECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-01-25
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: SIGNED

Cellulose and lignin constitute an unlimited natural resource for materials production, with the potential to substitute most of the currently used petroleum-based products. However, processing biomass into value-added products, such as cellulose nanocrystals (CNCs) and lignin nanoparticles (LNPs) is strongly limited by the insolubility these biopolymers, and thus generally requires large volumes of caustic or toxic chemicals and clean water, while generating hazardous waste. The ENBIOMECH project will first develop sustainable, environmentally friendly and efficient methods to produce CNCs and LNPs from biomass by employing enzymes in mechanochemical approaches, through which chemical transformations can be achieved in the solid state without solubilization of the biopolymers. Mechanochemistry will thereafter be used to convert the CNCs into a set of self-sorting nanoscale building blocks, by developing new facile methods for covalent surface modification of CNCs. Finally, various solid-state techniques will be investigated to reach new chiral nanoarchitectures from the obtained CNC building blocks, by gaining control over their supramolecular assembly. Switching to mechanochemical methods provides a fast and simple route to materials discovery, thus the ambitious ENBIOMECH project seeks to deliver a strong impact to the field of renewable bio-based materials by offering resource-conserving technologies to researchers and industry, aligned with the EU goals for the development of a green and sustainable economy. This project will bring together the researcher skilled in mechanochemical methods with the leading experts in cellulose chemistry and nanostructured biohybrid materials (supervisors), within a host institution strongly focussed on the development of bio-based materials and dedicated infrastructure ideally suited for supporting the proposed research.

Keywords: mechanochemistry,cellulose nanocrystals
OLIVE LEAF MULTI-PRODUCT CASCADE BASED BIOREFINERY: FROM AN UNDER-USED BIOMASS IN THE PRIMARY SECTOR TO TAILORMADE SOLUTIONS FOR HIGH ADDED VALUE INTERNATIONAL MARKET APPLICATIONS (OLEAF4VALUE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Italy,Spain,Spain,Spain,Spain,Spain,Switzerland,Norway,Slovenia,Netherlands,Netherlands,Portugal,United Kingdom
Call: Extract bioactive compounds from new, under-exploited and/or recalcitrant residual bio-based streams for high-value applications (H2020-BBI-JTI-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 5687060.0
EU funding (EUR): 4530243.0
Participants: 17
Project status: SIGNED

OLEAF4VALUE is a three-year project that will develop a complete valorization system for the olive leaf. 4,5 million ton of olive leaves are produced annually in the world by the olive oil industry, a key industry in southern Europe and along the Mediterranean coast (Spain, Italy, Greece, Portugal, Slovenia, among others). This recalcitrant biomass represents a problem for both the farmers and the whole olive oil industry, who need to remove it from the fields and the olive oil mills. This biomass is nowadays burnt in the fields, given to the cattle or, in some cases, combusted to produce energy. OLEAF4VALUE will put together a competitive consortium of highly experienced partners devoted to the complete valorization of this new underexploited biomass. The consortium will address all the stages of the value chain: raw material, biorefining, post-extraction technologies, market validation and sustainability assessment. The goal of OLEAF4VALUE is to set up the basis of a smart value chain based on a newly developed 4.0 concept: Smart Dynamic Multi-Valorization-Route Biorefinery (SAMBIO) for the cascade valorization of the olive leaf biomass according to its physicochemical composition, particularly modulated by specific pretreatments to produce target products. Advanced green extraction and isolation technologies will be used to sequentially separate all fractions and compounds of value, with a zero-waste approach. Enzymatic biotransformation and nanoencapsulation technologies will be applied to develop tailor made prototypes according to end user market needs from high value sectors: food, feed, health, cosmetic, pharma and chemical industries. Large companies from these sectors within the consortium will guarantee a good market-oriented approach throughout the project. OLEAF4VALUE will link the primary olive sector from southern Europe with large multinationals from the high valued competitive markets in a circular bioeconomy project.

Keywords: olive leaf biomass,biorefinery,valorisation routes,side streams,extraction,biotransformation,molecularly imprinted materials,nanotechnology,preservatives,feed additives,health ingredients
Media in the face of digitalisation: Renewing capabilities and strategic thinking (DIGISTRAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

The innovative research project tackles acute questions of organisational renewal capacity and change management in the radically changing media sector. The key question is how media organisations can renew their thinking, resource bases and capabilities in order to stay competitive while addressing the challenges of digitalisation. The research is carried out by conducting qualitative and quantitative analyses based on data collected in the German media industry. The media context offers an excellent example of a dynamic business environment brought about by technological convergence, rapidly changing media usage behaviour and increasing global competition. The theoretical framework is based on modern theories of strategic management research, especially in relation to the dynamic capability view and the managerial cognition tradition. The combination of the two frameworks forms a unique multidisciplinary research approach that comprehensively helps European media organisations tackle organisational path dependencies and drivers of change. Understanding the factors that keep the media industry competitive is of great importance, because vital and diverse media is a key element of European democracy. The project is a pioneering piece of research into media management and opens many new options for projects and international collaboration as well as applications in other industries facing digital transformation. The unique interdisciplinary approach and research setting combined with a highly important topic of European interest remarkably improves the senior researcher’s competencies through applying new theories and analysis methods. The project also extends her teaching skills through opportunities at the host institution related to strategic management and the media sector than at her home university. As a result the fellowship considerably widens her career opportunities, especially as the study will spur wider interest in both academia and practice.

Keywords: strategic management,dynamic capabilities,media industries,digitalization,business models,competitiveness,organizational renewal
Defining the genetics of grapheme-colour synaesthesia (SynGenes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Synaesthesia is a common neurodevelopmental phenomenon (2-5% of the population) where stimulation of one sense automatically triggers an experience of another. Familial clustering indicates that synaesthesia is highly heritable. However, this genetic contribution is poorly understood and likely heterogeneous, a major hindrance to our understanding of the neurobiology. My objective is to remove this barrier through the most comprehensive interrogation of synaesthesia genetics to date, utilizing state-of-the-art technologies and integrative approaches. This study will focus on individuals who associate letters and numbers with colour (grapheme-colour synaesthesia), as this type of synaesthesia is common and the most reliably measured. I will apply two complementary approaches in parallel. Whole genome sequencing in two newly ascertained multigenerational synaesthesia families will determine the role of rare genetic variants (Work Package 1, WP1), while genome-wide genotyping of 1000 unrelated synaesthetes will unmask contributions from common variation (WP2). Using existing candidates and novel genes discovered in this work, I will perform multi-level in silico analyses to test if genetic information supports the prevailing theory of neural hyperconnectivity as an underlying aetiology (WP3). WP1-3 will help to define the genetic landscape of synaesthesia, while opening novel research avenues into the neurobiology of sensory perception. This fellowship will provide a diverse set of stepping-stones toward my professional goal of becoming an independent researcher in the rapidly advancing field of neurogenetics. The research and training plans will deepen my current skillset and add a suite of complementary informatics skills that will significantly enhance the quality and competitiveness of my scientific career. The multi-platform dissemination and public outreach strategy involves both the scientific community and main stakeholders at the major milestones (WP4).

Keywords: synaesthesia,human genetics,neuroimaging,gene expression,autism,sensory perception