Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Membranes And Catalysts Beyond Economic and Technological Hurdles (MACBETH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Germany,Italy,Germany,Spain,Spain,Spain,Austria,Germany,Germany,Spain,Italy,Germany,Türkiye,Belgium,France,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom
Call: Efficient integrated downstream processes (IA) (H2020-NMBP-SPIRE-2019, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 20611394.29
EU funding (EUR): 16606129.56
Participants: 31
Project status: SIGNED

The MACBETH consortium provides a breakthrough technology for advanced downstream processing by combining catalytic synthesis with the corresponding separation units in a single highly efficient catalytic membrane reactor (CMR). This disruptive technology has the ability to reduce greenhouse gas emissions (GHG) of large volume industrial process by up to 45 %. Additionally, resource and energy efficiency will be increased by up to 70%. The revolutionary new reactor design will not only guarantee substantially smaller and safer production plants, but has also a tremendous competitive advantage since CAPEX is decreased by up to 50% and OPEX by up to 80%. The direct industrial applicabilty will be demonstrated by the long term operation of TRL 7 demo plants for the highly relevant and large scale processes: hydroformylation, hydrogen production, propane dehydrogenation. The confidence of the MACBETH consortium to reach its highly ambitious goals are underlined by two special extensions that go well beyond the ordinary scope of an EU project: 1) Transfer of CMR technology to biotechnology: Within MACBETH we will demonstrate that starting from building blocks of TRL 5 (not from a TRL 5 pilot plant), that fit the requirements of selective enzymatical cleavage of fatty acids with the combined support and system knowledge of the experienced CMR partners, a TRL 7 demo plant will be established and operated 2) Creation of the spin-off European “Lighthouse Catalytic Membrane Reactors” (LCMR) within MACBETH: A European competence center for CMR will be established already within the MACBETH project with an actual detailed business plan including partner commitment. These efforts will ultimately lead to the foundation of the “Lighthouse Catalytic Membrane Reactors” (LCMR) that will provide access to the combined knowledge of the MACBETH project .

Keywords: catalytic membrane reactors,process intensification,advanced downstream processing
DRES2Market: Technical, business and regulatory approaches to enhance the renewable energy capabilities to take part actively in the electricity and ancillary services markets (DRES2Market)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Spain,Spain,Norway,Greece,Poland,Poland,France,France
Call: Market Uptake support (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-08-01
End date: 2023-01-31
Duration (months): 30.0
Total project cost (EUR): 2998597.5
EU funding (EUR): 2998597.5
Participants: 18
Project status: CLOSED

The main aim of the DRES2Market project is to develop a comprehensive and affordable approach to facilitate the effective participation of distributed generation based on renewable energies in the electricity markets, and enable to provide balancing and reserve services according to market criteria DRES2Market is focused on overcoming the existing barriers (technology and regulatory framework) for developing the integration of these technologies, based on the following issues: - The evaluation of the existing technologies (power generation, energy storage solutions, smart technologies, etc.) to design appropriate approaches for the effective integration of distributed generation in the electricity and ancillary services markets, propose the evolution of the technology to fulfil with the requirements to participate in these markets and recommend standards for these technologies. - The analysis of the existing grid codes and markets rules in the European markets to assess their capacity to enable the participation of variable renewable energy. - The identification of opportunities for the active participation of final consumers (based on distributed generation) in the penetration of these technologies, according to market criteria, proposing collaborative schemes. - The identification of arguments of the positive impact of these technologies, to obtain the social acceptance of these technologies. This initiative includes validation procedures based on computing and simulating processes based on real conditions. DRES2Market consortium includes the key players for the system integration of variable renewable energy: balance responsible parties; market operators, grid operator; providers of technology solutions; prosumers; retailers that can develop the aggregator role; renewable energy players; research and development (R&D) institutions and consultants with large expertise in renewable energy integration in electricity systems.

Keywords: distributed generation,market,ancillary services,solar photovoltaic,prosumers
Neuronal microscopy for cell behavioural examination and manipulation (REVEAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Germany,Germany,Poland,France,France,France
Call: Disruptive photonics technologies (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 5984599.75
EU funding (EUR): 5984599.75
Participants: 10
Project status: SIGNED

The REVEAL project aims at installing a novel microscope at the interface of instrumentation, machine learning and Biology. This new microscopy technique will rely heavily on neural networks to be able to perceive, interpret, conjecture, infer, anticipate and act. The present project intends to lay down the foundations of this ‘neuronal microscopy’ in the realms of 2D and 3D cell live imaging. To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases. REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time . The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.

Keywords: instrumentation,machine learning,biology,neural networks,cell live imaging,cell picking microscopy,biophotonics,3d refractive index microscopy,quantitative phase imaging,label free imaging
Epigenome maintenance in response to DNA damage (REMIND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1738750.0
EU funding (EUR): 1738750.0
Participants: 2
Project status: SIGNED

Cell viability and homeostasis rely on the stable maintenance of the epigenetic information conveyed by chromatin, which associates DNA and histone proteins in the cell nucleus and governs gene expression programs. Yet, epigenome integrity is challenged during all DNA transactions, including DNA damage repair. While much effort has been devoted to characterizing chromatin alterations in response to DNA damage and how they contribute to the repair response, our knowledge of this fundamental process is largely incomplete, and whether and how epigenetic features are re-established following a genotoxic stress challenge is still unexplored. Thus, a comprehensive framework of the mechanisms underlying the maintenance of epigenome integrity in response to DNA damage is lacking. The present project aims to fill this important gap by profiling the epigenome of repair patches following UVC damage in human cells and by characterizing the molecular players contributing to chromatin restoration/plasticity. I propose an integrated approach that tackles this question at different levels of chromatin organization, from histone and DNA modifications up to higher-order chromatin folding. Building on our unique expertise and through the development of powerful novel methodologies, combining cutting-edge imaging, proteomics and epigenomic technologies, we will elucidate mechanisms for (1) histone modification re-establishment and maintenance and (2) DNA methylation inheritance at repair sites. We will also investigate how repair-associated changes in DNA and histone modifications reflect at the level of (3) higher-order chromatin organization in the tridimensional nuclear space, and dissect (4) functional crosstalks between the epigenetic changes that arise in damaged chromatin. This ambitious research project represents an unprecedented effort towards a comprehensive and integrated understanding of epigenome maintenance mechanisms in response to genotoxic stress.

Keywords: dna damage repair,epigenome integrity,histone modifications,dna methylation,higher order chromatin organization
Is There No Such Thing As Childhood? New Childhoods in Britain and Turkey between 1976 and 1997 (CHIBRIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This project will focus on changing ideas about childhood in Turkey and in Britain in the late twentieth century, an era characterised with the erosion of traditional safety nets, increased inequality, and social insecurity. Based on a comparative critical discourse analysis of the news coverage of children in selected national newspapers and using theoretical frameworks from childhood studies, the project will discuss how the actual transformations of childhood have translated into ideas about childhood, and analyse how these were reflected, shaped, and diffused by the news media in each country. Which social, political, cultural, and demographic changes brought by the 1980s and the 1990s were given a prominent place in the public agenda? Who were the idealised children included in the category of childhood, and who were the outcasts that did not fit this ideal? How were concepts such as children’s culpability, parental liabilities, and social responsibilities to children negotiated? In addressing these research questions, the objectives of this project are to compare the conceptualisations of childhood in these distinct examples, investigate the distinctive characteristics of “new childhood” paradigms, map shared patterns that cut across and travel through contextual and local differences. To achieve that, this research project proposes to analyse the idea of childhood within a framework of social and historical change in the wider sense. Such an intersectional and relational lens allows us to make sense of different childhoods, comprehend not only their plurality but also their shared origins, and illuminate not only the diverse ideas about childhood, but also the common discourses that frame them. The investigation of these ideas and discourses within a comparative frame of analysis has the potential to culminate in an original contribution to the literature on the manifestations of shared global processes in specific localities.

Keywords: childhood studies,sociology of childhood,distinction,discrimination,inequality,social change,neoliberalism,turkey,britain,1980s,1990s,new right,newspapers
The Sensuous Appeal of the Holy. Sensory Agency of Sacred Art and Somatised Spiritual Experiences in Medieval Europe (12th-15th century) (SenSArt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1499328.0
EU funding (EUR): 1499328.0
Participants: 1
Project status: SIGNED

Is sight the only sense actively involved in the perception of art? This is a crucial question for Western culture, dominated today by the hegemony of vision and the suppression of the other senses. By challenging the current ocularcentric paradigm, and assimilating notions on the cultural values of sensation, SenSArt provides the first examination of medieval sacred art from the unconventional lens of its sensory agency. Between the 12th and the 15th century Europe underwent an extraordinary artistic evolution and an impressive cultural revitalization, which sparked a reassessment of the role of sensory perception in systems of knowledge and spiritual enlightenment. SenSArt explores and compares different social environments in six selected regions, pursuing three groundbreaking objectives: A) it will analyse quantitatively and qualitatively the perceptual schemes that orientated the reception of sacred art, scrutinizing how art solicited its beholders through multiple sensory inputs; B) it will develop and investigate the new notion of ‘sensory agency’ of art, establishing sacred art as a primary actor capable of exerting, through sensorial stimulation or deprivation, a social agency on its audience; C) it will provide an overall phenomenology of experiences on a European scale, by comparing the diverse patterns that different social groups lived on a local, regional and supranational scale. SenSArt will achieve its goals by developing a new combined approach at the crossroad of Art History, Philosophy and Text Studies; it will establish a multidisciplinary team of scholars to delve into a comparative set of materials, including normative texts on the senses and works of art. The project promises to bring about a paradigm shift in our understanding of Medieval Europe. It will shed new light on wide historical, devotional and cultural phenomena, outlining complex networks of social interactions where humans, art and the senses interplayed with each other.

Keywords: medieval art,medieval europe,spirituality,senses,sensoria
A rapid and cost-effective point-of-care diagnostic kit able to predict treatment response for appropriate Multiple Sclerosis management (ScleroTest)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system currently affecting about 2.5 million people worldwide (mainly young adults, three times more women than men). There is no cure and therapies do not properly work in all patients. Personalized medicine is needed but we lack predictive biomarkers for treatment response to secure prompt and early treatment and the best clinical outcomes for each patient. Thus, MS represents a major public health issue with a substantial socioeconomic impact (€15.5 B annual costs in Europe). Bioithas is a biotechnology company in the field of health developing new diagnostic and therapeutic targets for autoimmune and inflammatory diseases. In response to the unmet need, it is focused on developing the first-ever gut microbiota based biomarker for predicting MS treatment response. ScleroTest, a quick point-of-care (PoC) diagnostic tool, will allow immunomodulatory profiling of patients to predict treatment response. It is a non-invasive, accurate (PCR performance), rapid (results in <24 h) and cost-competitive test (€25 test, ca. 58 % cheaper than magnetic resonance and JC virus alternatives). ScleroTest implantation in routine practice will face current MS management problems resulting on added value for patients, neurologists and health systems by allowing fast and correct therapy choice, better clinical outcomes and cost-savings. ScleroTest scalability will also open new avenues for personalized therapy in other diseases. Due to ScleroTest´s cost-competitive features plus the absence of real competition, the increasing MS prevalence and incidence globally and the growing PoC market (CAGR 10%, €33 B by 2022), Bioithas foresees ScleroTest as a fruitful business opportunity (accumulated net profit ca. €18.02 M, 2022-2026). To secure the successful market launch, we will perform a feasibility study analyzing technological, commercial and financial aspects to finalize our business plan.

Keywords: multiple sclerosis,medical device,non invasive,bacteriology,gut microbiota,predictive tools,treatment response
Quantum Metrology in Applications (Q-METAPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Quantum technologies will soon change the way we communicate, compute and measure phenomena. Due to the industry-oriented research in quantum metrology, methods have already been demonstrated that allow to perform measurements with unprecedented precisions—limited only by the quantum structure of nature. In recent years, new sophisticated techniques have been developed to more accurately describe such quantum metrological protocols and, in particular, account for the noise effects inevitably present in their implementations. The main objective of Q-METAPP is to propose a new generation of noise-robust sensing technologies by utilising these novel tools, and furthermore study their potential use in other branches of quantum information theory. The action will involve state-of-the-art theoretical research at the frontiers of quantum physics, statistics and probability theory, with its major part dedicated to designing quantum optical experiments. It will require strong collaboration between many theoreticians, also from other European institutions, and direct consulting with the experimental groups. The main goal will be achieved by proposing atomic magnetometry setups, in which the noise effects can be eliminated due to the careful engineering of the apparatus geometry, and by exploring the so-called Quantum Zeno Effect intrinsic to quantum systems. Moreover, multi-parameter estimation scenarios will be studied, in order to design quantum-enhanced protocols allowing to simultaneously sense many parameters in photonic experiments. In the second part, open problems in quantum thermodynamics, non-Markovian dynamics and communication theory will be approached with use of the metrological tools. Last subproject will focus on explaining the fundamental role of quantum correlations in metrology. The action, having a substantial impact on the development of quantum technologies, will greatly increase future mobility and career advancement possibilities of the applicant.

Keywords: quantum metrology,decoherence,quantum information theory,quantum magnetometry,quantum optics and photonics,estimation theory and data inference,statistics
GUT biota indices: a new tool for WILD animal conservation (WILDGUT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-08-30
Duration (months): 24.0
Total project cost (EUR): 176203.8
EU funding (EUR): 176203.8
Participants: 2
Project status: CLOSED

Calls to stem biodiversity loss have generally focussed on the plight of charismatic vertebrates (mammals, birds, fish, amphibians) and to some extent, insects (like butterflies). However, although the abundance and diversity of microbial and helminth communities inhabiting the gastrointestinal tract have been demonstrated of critical importance to health in both humans and non-human animals, this microbiodiversity has rarely been considered within a conservation framework. Using recently collected fecal samples from two free-ranging tropical non-human primate species with contrasting ecological parameters, WILDGUT proposes a multi-disciplinary approach to investigate the four-way interplay between habitat changes, host species, and gut micro- and macro-parasites in natural environments. The results will lead to a better understanding of the impact of human activities on microbiodiversity, and whether such changes could have an effect on wildlife health, and ultimately to a species’ conservation status. Thus, the project will explore whether the comparison of gut microbiota and helminth community diversity, functions and interaction between intact and degraded habitats can be used to develop new indices to estimate host health and informing conservation strategies.

Keywords: gut microbiota,helminth,metataxonomics,conservation biology,habitat disturbance,non human primates,tanzania