Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

The goal of the Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME) project is to examine the functional neuroplastic mechanisms underlying mitigatory effects of bilingual experience on age-related cognitive decline. While evidence is available for structural brain changes supporting bilingualism-induced effects on cognitive aging (CA), functional mechanisms underlying such effects are not yet well understood. BECAME aims to fill this gap by investigating the trajectory of bilingualism-induced functional neuroplasticity across the adult lifespan (ages 18-85), crucially adopting an individual differences approach related to measurable degree of bilingual engagement. Importantly, although such benefits are thought to be rooted early in the lifespan, evidence for the timeframe and conditions of their early emergence is scarce. The choice of including the whole adult lifespan allows us to investigate these mechanisms and their emergence more directly from a lifespan perspective. I combine behavioral testing with brain recordings via electroencephalography (EEG). EEG is widely used in cognitive neuroscience to assess brain activity and the degree of communication between brain regions (functional connectivity) in response to stimuli and at rest. Combining behavioral and EEG modalities will allow me to test bilingualism’s effect on functional connectivity, as well as its consequences for functional efficiency, the minimum required neural activation to successfully perform a task. This will enable a detailed, evidence-based account of the protective effects observed in older-aged bilinguals, and how they are built from earlier life stages. By illuminating the relationship between multilingualism and resulting neurocognitive adaptations, BECAME will enable to capitalize on it as a health initiative, with manifold societal implications and the potential to be translated into actionable policies exploiting multilingualism to ameliorate effects of CA.

Keywords: bilingualism,cognitive aging,multilingualism,cognitive reserve,eeg,functional connectivity,oscillatory activity,neurocognitive adaptations
Ships Harbouring in Ports (SHIPs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2723617.5
EU funding (EUR): 2723617.5
Participants: 1
Project status: SIGNED

Until the emergence of the modern container ship, vessels spent a significant part of their lifespan in a harbour. The time period when a ship sets anchor in a harbour is key as the entire harbour was designed to offer mooring and all the facilities required for her stay. Yet, a harbour was not merely the accumulation of standings structures made of stone, concrete, or wood that helped ships make fast in Roman harbours. Associated activities extended beyond their principal basin, taking place on a far larger scale and in an agglomeration of different areas than previously conceived by scholars and archaeologists. These together constituted a harbour system, one of the most significant foundations of ancient economies. The project’s aims are 1) to identify the various operational parts of harbours, 2) to consider how the functions carried out there were combined into a larger area, and 3) to consolidate a set of tools that together comprise a unified methodology, which can be applied to examples elsewhere. Beyond these larger concerns, the project explores specific issues regarding ships when mooring in harbours: what type of vessels did they include? What were their needs and what structures could fulfil them? Did they change according to the different seasons of the year? The project comprises an investigation of what we term a “harbour system,” relying on the three case studies of Caesarea, Terracina, and Port-Vendres, and considers the specificities of each site and their individual environmental context. The end goal is that the interdisciplinary methodology developed by our project at the above sites explored within a comparative framework can be later adapted and applied to similar harbour sites elsewhere.

Keywords: harbour archaeology ship archaeology maritime trade ancient economy ancient society
diGitAL twin frAmework for TailorEd infAnt nutrition (GALATEA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Greece,Switzerland,Spain,Poland
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 1269600.0
EU funding (EUR): 1104000.0
Participants: 11
Project status: SIGNED

The research and innovation program, named GALATEA, stands as a pioneering venture targeting infant nutrition through the development of a digital twin of human milk. The program brings together interdisciplinary expertise from computational modeling, bioinformatics, clinical neonatology, experimental lab techniques, and engineered bioreactors for cell culturing, forming a consortium dedicated to advancing our understanding of human milk's complexities. The overarching objective is to create a sophisticated simulation platform that mirrors the intricate composition of human milk, allowing for the formulation of personalized nutrition plans for infants, particularly those born prematurely. GALATEA's innovative spirit extends beyond computational models, encompassing experimental lab work utilizing bioreactors and cutting-edge techniques like metabolomics and proteomics. The program's mobility component facilitates cross-disciplinary learning among participating organizations, fostering collaborative knowledge exchange. Anticipated outcomes include enhanced health outcomes for newborns, a deeper understanding of human milk for the advancement of artificial milk formulations, and the establishment of a robust research community dedicated to neonatal nutrition. GALATEA represents a holistic and innovative approach to the fundamental challenge of infant nutrition, setting new standards for personalized strategies and collaborative interdisciplinary efforts.

Keywords: digital twin,personalized nutrition,human milk,neonates,preterm,bioinformatics,multiscale,molecular modelling
Mapping and Direct Sequencing of the Non-Canonical Cap Code (MaDCap)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

From their creation to their degradation, mRNAs are under extensive regulation. This regulation is directed not only by their nucleotide sequence and their promoter but also by post- and co-transcriptional modifications attached to the RNA. One of the most ubiquitous of these modifications in eukaryotes is the 5' cap — typically a methylated guanine (m7G) attached inversely to the first transcribed nucleotide. Several decades of research have revealed the m7G cap as an interface for regulating stability, splicing, polyadenylation, localization, and translation. The m7G cap was long presumed to be the only functional cap in eukaryotes, but this view was recently overturned by the discovery of the non-canonical nicotinamide adenine dinucleotide (NAD+) cap. Following this, several other eukaryotic cap structures were discovered: NADH, flavin adenine dinucleotide (FAD), uridine diphosphate glucose (UDP-Glc), and uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). The function of most non-canonical caps is unknown, but their presence suggests the existence of a regulatory “cap code”. Currently, the complete cap structure can only be identified through bulk methods that cleave caps from their transcripts, thereby losing the link between mRNAs and their specific caps. For NAD-caps enrichment techniques exist that can be followed by sequencing, but no such method exists for other non-canonical caps, and no sequencing method exists that can identify more than one cap. This limitation is a significant obstacle in understanding the cap code and the function of its more enigmatic members. The objective of this project is to 1) develop a novel single-molecule method that can directly sequence native caps with their full-length RNA transcripts, 2) use this method to characterize the cap-ome across tissues and development, and 3) use the resulting temporal and spatial atlas of capped RNAs to determine the function of non-canonical caps and understand the non-canonical cap code

Keywords: mrna capping,nanopore sequencing
Moving Emotions towards confidence in the Transformative Appropriation for a Meaningful Understanding of cultural heritage: a neuroScientific approach to EUropean Museums (META-MUSEUM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Greece,Germany,Poland,Lithuania,Romania,Sweden,France,Spain
Call: Cultural heritage in transformation – facing change with confidence (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 2952857.5
EU funding (EUR): 2952857.5
Participants: 14
Project status: SIGNED

META-MUSEUM aims to create empathic encounters where citizens can understand the CH transformative nature through active participation, emotional involvement and co-creation; to develop the “TransforMeans theory” and related new professional skills, based on Neuroscience evidence; to provide cultural professionals with principles and tools for designing cultural experiences and to monitoring the effectiveness of communicative/narrative solutions; to reach different segments of citizens, included disaffected public and non-public; to foster empathy, confidence and resilience toward contemporary changes; to validate an appropriate measurement of empathic responses, confidence and resilience in CH users, via Neuroscience’s method. META-MUSEUM adopts a transdisciplinary approach and a strict interrelation between theoretical and experimental work. The first one will explore and develop in-depth the “TransforMeans theory” principles, develop stimuli to make people understand the CH transformative nature and encourage co-creation and personal interpretation. The experimental work will measure the audience's cognitive, psycho and neurophysiological responses to stimuli, and interpret indicators related to confidence and resilience (intended as a capacity to positively react to changes). The “TransforMeans theory” principles will be tested in 3 different settings (pilots): 1) traditional cultural setting: museums; 2) non-cultural setting: hospitals (WITHOUT focusing on “therapy results”, but only on the CH power on people particularly lacking in confidence and positive thinking); 3) hybrid setting (physical and virtual), in urban contexts and via social media. The META-MUSEUM objectives mobilise multidisciplinary expertise, provide evidence-based principles and guidelines; promote better and more democratic access to CH, improve personal participation and CH understanding, enhance confidence, and address the SDG4, SDG10 and SDG11.

Keywords: empathy,participation,emotions,co creation,professional skills,inclusion,resilience,personal interpretation,audience s response,transdisciplinary approach
Adaptive Dynamics of the Maternal Immunity in Human Skin During Pregnancy (SkimmunePreg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

A successful immune adaptation to pregnancy is essential to support mammalian reproductive fitness. Pregnancy presents a immunological dilemma where the maternal immune system must tolerate fetal antigens while maintaining its main protective functions. How the maternal immune system navigates these opposing demands and adapt to pregnancy remains largely unclear. This question is of importance at barrier sites such as the skin that represents a primary portal of infection and inflammatory disorders. Clinical observations support the idea that skin physiology and immunity are altered during pregnancy. Using experimental models, the host laboratory uncovered a remodeling of skin immunity during pregnancy associated with a significant increase in regulatory T cells and an altered dendritic cell network. The goal of our proposal is to understand how pregnancy impacts human skin with the ultimate goal to develop approaches to mitigate inflammatory responses during this critical stage. More specifically, this project aims at exploring how pregnancy impacts human skin immune landscape and putative function both at steady state and in the context of inflammation. This high dimensional analysis will be performed using high resolution transcriptomic technologies including single cell ATAC / RNA sequencing and spatial transcriptomics. My expertise in these approaches will enable me to uncover underlying putative signalling pathways underlying immune cell changes and highlight pregnancy associated altered cell interactions. Candidate pathways will be validated using organoids mimicking pregnant skin. The generated data are expected to capture, for the first time, how the skin adapts to pregnancy. This work may provide fundamental insights into our understanding of maternal immunity and would potentially enable risk prediction and alleviation of inflammatory skin conditions that can appear or be exacerbated in pregnancy.

Keywords: immunology,skin,pregnancy,single cell rna sequencing,spatial transcriptomics,organoids
Demonstrating large pit thermal energy storages and improving their components, processes and procedures for an accelerated realisation of 100% sustainable district heating networks in Europe. (TREASURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Austria,Denmark,Germany,Czechia,France,Belgium,Poland
Call: Demonstration of innovative, large-scale, seasonal heat and/or cooling storage technologies for decarbonisation and security of supply (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 11408817.7
EU funding (EUR): 9894688.4
Participants: 24
Project status: SIGNED

A fully decarbonised European energy system must be equipped with very large flexibility capacities, enabling the uptake of intermittent renewable sources, coupling energy sectors, and increasing the energy system efficiency. The TREASURE project paves the way for the accelerated realization of large pit thermal energy storages that serve as the enabler for fully renewable district heating networks and industrial heating systems. With the project, 7 demonstrators are being realized in 5 different countries. The projects` aim is to use synergies in order to improve cost effectiveness through the targeted development of improved components and the collective improvement of design and building processes. Monitoring data from an already operating storage and from the demonstrators are used for better numerical simulation of actual and future system performance. Through the participation of market-oriented partners possible solutions to the financing, permitting, and social challenges in the realisation of large pit thermal energy storage projects are mapped and discussed with the broad group of stakeholders, with a core group of 15 satellite initiatives. The experience with the operation, maintenance and refurbishment of especially Danish pit thermal storages is used to improve the design and operation of the demos, the satellite initiatives and future storages in broad. The project consortium is composed of partners from the complete value chain; component suppliers, building companies, engineering companies, research and developments institutes, contractors, energy service providers, district heating companies and professional organizations. The developed roadmap and generated knowledge in the fields of planning, design, components, building, system integration, financing, permitting and business plans is actively disseminated to experts and to decision makers in order to accelerate the realisation of more than 2000 large PTES needed for the full decarbonisation.

Keywords: pit thermal energy storage district heating flexible sector coupling
WISER: Well-being in a Sustainable Economy Revisited (WISER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Germany,South Africa,Italy,Luxembourg,Colombia,Finland,Tanzania, United Republic of,Peru,Greece,Ghana,Kenya,United Kingdom,Hungary,Romania,Algeria
Call: Public policies and indicators for well-being and sustainable development (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2915673.75
EU funding (EUR): 2915673.25
Participants: 24
Project status: SIGNED

The focus on economic growth as an instrument to lead societies towards sustainable high well-being is increasingly problematic. While Gross Domestic Product (GDP) growth is slowing, its environmental and social costs are increasing, such that continued reliance on GDP growth entails a trade-off between the well-being of current versus future generations. In addition, research shows that higher GDP generally hardly improves people’s subjective well-being. To better support policy options, our project aims to develop a new economic development framework that provides evidence-based and theoretically-sound policy insights on how to raise well-being of present generations (leaving no one behind) without sacrificing future well-being. We will identify how GDP growth and productivity growth can be promoted and invested in well-being, focusing on relationships that reconcile economic growth and sustainable high well-being while leaving no person and place behind. We will analyze how these relationships work at different subgroup levels, by explicitly considering gender perspectives and disadvantaged groups. The project’s multi-disciplinary approach integrates knowledge from different disciplines, combining quantitative and qualitative techniques to generate solid evidence. Our case studies will permit deriving important lessons from different regions of the world, Africa in particular. Moreover, the relevance of our policy recommendations will be supported by insights from and interaction with stakeholders. Within the triadic goals of well-being, sustainability, and productivity, the project looks for possible win-win-win pathways, producing a new economic development framework that provides insight into how societies can use greater productivity to aim at greater human well-being. Policymakers will be helped by means of a dashboard and green book, which provide guidance how to achieve sustainable growth and maximize well-being.

Keywords: subjective well being,psychology,sociology
Causal Argumentative Learning Assistant (CArLA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Causal AI is widely perceived as crucial in the current AI landscape as it allows capturing causal effects amongst features in data, rather than simple correlations. Causal discovery is an important aspect of machine learning as it paves the way towards achieving Causal AI. It amounts to extracting causal graphs from data, encoding the structure of causal relations amongst features in data. There is a gap in the state-of-the-art in AI as concerns causal discovery, in that most approaches are black-boxes, hard to understand and explain, and unable to engage domain experts to integrate and possibly contest the learnt graphs when they are misaligned with human knowledge and values. CArLA aims at developing a platform for transparent, explainable, interactive and contestable causal discovery, based upon an existing principled methodology and prototype, as well as XAI techniques, developed within the ERC Advanced ADIX project. CArLA’s platform will support understanding the causal discovery process from data and experts while being able to influence it. Any developer or user of applications in high-stakes domains will benefit from using this uniquely trustworthy platform. CArLA aims to develop two demonstrators of the beneficial use of the platform in the high-stakes domains of healthcare and finance, to pave the way to commercialisation with a spinout.