Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Debating Deltas: The early medieval river mouth’s historical ecologies (6th-10th centuries AD). An interdisciplinary and comparative approach (De.ltas)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

This project will pursue an interdisciplinary methodology to analyse how and why the early medieval European deltas became primary gateways for interaction between sea and inland territories, and how they influenced the new socio-economic scenario after the fall of the Roman economic system. I will compare two Mediterranean cases, the Rhone and the Po deltas, with the North Sea cases of the Rhine and Elbe deltas between the 6th-10th centuries AD. Historical document and archaeological analyses in one of the most-active research clusters of early medieval Europe (UrbNet) will be paired for the first time in these areas with new cutting-edge remote-sensing technologies and network modelling analysis, allowing to: a) reconstruct the early medieval delta’s landscape; b) understand how deltas’ environment influenced the form and development of socio-economic networks; c) assess what kind of impact people and goods had on deltas and related societies; and d) identify and, possibly, define a ‘delta identity’ establishing a new research trend. De.ltas, through its interdisciplinary approach and the support of leading scholars in both archaeological (Sindbæk) and landscape (Kristiansen) analysis of wetland environments, has the potential to highlight the crucial socio-political and economic role of interaction in delta areas, reassessing the opinion of an early medieval socio-economic stagnation in the Mediterranean in this phase. Moreover, the case-study areas, at the borders of the post-Roman ‘European Union’ under the Franks, will allow me to investigate the permeability of delta societies engaging with migration, cultural integration and self-definition, and the anthropic interaction with climate change and environmental threats which are pressing contemporary issues. Finally, this project will fill a research gap concerning the development of early medieval socio-economic systems linked to river deltas, an overdue research question not yet fully tackled.

Keywords: river deltas,post roman europe,post roman mediterranean,early middle ages,socio economic network
Control of Cytoplasmic Inheritance in Plants (CytoInP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1476476.0
EU funding (EUR): 1476476.0
Participants: 1
Project status: SIGNED

In plants, genetic material is stored in the nucleus and the two cytoplasmic organelles: plastids and mitochondria. While both the nuclear and cytoplasmic genomes are essential for plant survival, the inheritance of these genomes is subject to different sets of rules. Cytoplasmic inheritance differs from nuclear inheritance through two unique phenomena: uniparental inheritance and vegetative segregation. Despite extensive research efforts, the molecular basis of uniparental inheritance and vegetative segregation remain elusive. A major challenge in unraveling the mechanisms is the lack of methodologies. Excitingly, recent advancements in cytoplasmic genome engineering have provided me with a unique opportunity to develop feasible approaches for exploring this crucial area of biology. The ultimate goal of this project is to achieve a comprehensive understanding of cytoplasmic inheritance, which will, in turn, enable us to control the plastid and mitochondrial inheritance. To attain this ambitious goal, we will pursue three specific aims: (1) Identifying the factors that govern maternal inheritance, (2) Promoting the selective transmission of cytoplasmic genomes, and (3) Investigating the molecular basis of vegetative segregation. In this project, we will utilize a combination of genetic and cytological approaches to study cytoplasmic inheritance in the model plants Arabidopsis thaliana and Nicotiana tabacum. The success of our project would represent the first instance of controlled cytoplasmic inheritance in plants. Our fundamental research will provide new tools for testing existing hypotheses regarding cytoplasmic inheritance. From an agricultural standpoint, breeders can leverage this unprecedented capacity to selectively transmit cytoplasmic genomes, thus enabling the inheritance of desired crop traits. The potential application of cytoplasmic inheritance in plant breeding highlights the societal impact of our research.

Keywords: plastid inheritance mitochondrial inheritance cytoplasmic male sterility
ZERO-ENABLING SMART NETWORKED CONTROL FRAMEWORK FOR AGILE CYBER PHYSICAL PRODUCTION SYSTEMS OF SYSTEMS (Zero-SWARM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Greece,Sweden,Finland,Austria,Italy,Germany,Belgium,Portugal,Poland,Spain
Call: Data-driven Distributed Industrial Environments (Made in Europe Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2025-02-28
Duration (months): 33.0
Total project cost (EUR): 9939688.79
EU funding (EUR): 8052023.0
Participants: 30
Project status: CLOSED

Zero-SWARM is a mission to achieve climate neutral and digitised production via a multidisciplinary, human centric, objective oriented innovative approach resulting in technical solutions for open swarm framework, non-public 5G network, active information continuum and digital twin. At the core, it establishes a unique forum where separately maturing technologies of 5G and cloud-edge continuum, data technologies and analysis (including data spaces and GAIA-X) and operational technology (automation and agility) break their siloes to co-design and co-create through 10 trials. It will showcase key achievements such as smart assembly, sustainable powertrains, improved resilience with remote operation, 5G powered PLC?s for real time distributed control systems, safe and autonomous transport of goods in factory, 5G enabled process aware AGVs, plug & connect 5G for industry, mobile intelligent agents for zero plastic waste, smart maintenance and optimization, remote quality control for zero defect resilient manufacturing. The project includes 3 nodes (north, center and south) with industrial test facilities from previous public/private investments co/creating with reputable industry players. Aligned with the technical activities, Zero-SWARM includes a tailored engagement program towards a wide audience, including collaboration with Digital Innovation Hubs and key initiatives in Europe. In addition, open innovation practices involves industry player as clients of developed technologies via Zero-SWARM community with 400 users and the expression of interest mechanism. It allows them to be the pioneer of the Zero-SWARM technologies, establishing an impact pathway even after the project end. Zero-SWARM puts strong emphasis on developing various learning materials to promote skill development of talented workforces with minimum efforts in prominent twin transformation, which will strongly contribute to build up European leadership in sustainable data driven manufacturing.

Keywords: cyber physical system of system,5g,nonpublic network,cloud edge continuum,active information continuum,swarm intelligence,cybersecurity,asset administrative shell,opc ua,digital twin,agv
Hydrogen for Cogeneration in Flexible operation (HyCoFlex)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,France,United Kingdom,Belgium,Greece,Netherlands,Norway
Call: Retrofitting of existing industrial sector natural gas turbomachinery cogeneration systems for hydrogen combustion (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-02-01
End date: 2027-04-30
Duration (months): 39.0
Total project cost (EUR): 7073275.0
EU funding (EUR): 4442550.75
Participants: 12
Project status: SIGNED

HyCoFlex is aiming at the development of a retrofitable decarbonisation package for cogeneration of power and industrial heat with 100%-fired gas turbines. The solution will be integrated and fully demonstrated at an industrial site in Saillat-sur-Vienne in France. HyCoFlex will leverage on and further advance the infrastructure of a power-to-hydrogen-to-power industrial scale plant which was developed and demonstrated within the HYFLEXPOWER project. The project will develop operational flexibility capabilities and protocols to satisfy the typical operating profiles experienced by industrial cogeneration plants. By doing so, HyCoFlex will elaborate credible pathways for upscaling and replicating the retrofit package, ultimately accelerating the achievement of industrial and energy sector decarbonisation. In order to meet the global objective, within the HyCoFlex project, the HYFLEXPOWER plant concept and infrastructure will be implemented for 100% H2-fuelled cogeneration. In the framework of the project a Siemens Energy SGT-400 gas turbine will be upgraded with an advanced dry low-emission (DLE) H2 combustion system to operate with different natural gas / H2 fuel mixtures. The retrofitted demonstrator plant will be validated for flexible operation under various natural gas/hydrogen mixtures and loads, while aiming at overcoming state-of-the-art efficiencies with decreased NOx emissions. Finally, HyCoFlex will explore pathways for upscaling and commercialization of decarbonised power generation from gas turbines within a circular-economy framework.

Keywords: cogeneration,100 h2 gas turbine,dle combustion,retrofit,demonstration
Dynamic Earth Impacts on Past, Present, and Future Sea Levels (Earth2Sea)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1499622.0
EU funding (EUR): 1499622.0
Participants: 1
Project status: SIGNED

Nearly 700 million people live along flood-susceptible coastlines and actionable sea-level forecasts are urgently needed to protect these populations and their €4 trillion of critical infrastructure from rising sea levels. Unfortunately, current sea-level projections are of limited use due to deep uncertainties in the ice-sheet model calculations used to produce them. For example, the last Intergovernmental Panel on Climate Change report found end-of-century sea level could reach anywhere from 0.3 to 2 m above present. Most of this uncertainty relates to ice-sheet instabilities that, once triggered, could lead to rapid sea-level rise. It can be substantially reduced by calibrating model parameterisations of these instabilities so that they reproduce past ice volumes, but the reliability of existing calibrations is challenged by the recent discovery that mantle flow generates much faster changes in Earth’s surface elevation than had been recognised. This paradigm shift in geodynamics implies that: i) accepted estimates of past ice volume may be ~25–50% too high, since the ancient shoreline elevations underpinning them have been uplifted by mantle flow; and ii) existing models are missing key physics, leading them to underestimate modern post-glacial bedrock rebound rates by a factor of ~10 and overestimate ice-sheet instability. I will solve these issues by integrating new sea-level marker datasets with innovative mantle flow reconstructions to obtain probabilistic and geodynamically corrected estimates of past ice-sheet volume and sensitivity. By calibrating ice-sheet models that are compatible with this revised understanding of the palaeorecord and correctly incorporate mantle–ice-sheet feedbacks, I will produce the first geodynamically accurate global and regional-scale sea-level projections. These groundbreaking forecasts will enable decisionmakers to improve long-term coastal defence plans and better protect human life.

Keywords: cryosphere geodynamics palaeoclimate geomorphology mineral physics rock rheology machine learning
Integrating Systems Bioinformatics approaches for Point-of-Care Cardiovascular disease diagnostics (PoCCardio-SB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Austria,Cyprus
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

PoCCardio is a large-scale project developing a point of care (PoC) device for cardiovascular disease (CVD) risk stratification in post-myocardial infraction (MI) patients. This project includes a large clinical trial with MI patients and collects clinical data, biomarker readings and outcome data. In order to fully analyze this dataset a holistic bioinformatics approach is necessary. PoCCardio-SB will employ a “systemic” approach, which considers a disease in the framework of a complex network emerging from the integration of information from various levels. This falls within the realm of Systems Bioinformatics (SB). SB harnesses the powerful methods of network science to integrate information across different levels/sources as well as extract useful features from complex biological networks. This is critical for advancing Predictive, Preventive and Personalized Medicine, shifting healthcare from delayed and untargeted treatments to precise, preventive strategies. The Bioinformatics Department at The Cyprus Institute of Neurology and Genetics will contribute by refining the diagnostic and prognostic signature for CVD using state of the art SB. Genomic and proteomic biomarker readings from PoCCardio will be utilized to develop integrated networks combining both sources. The networks will also incorporate prior knowledge, derived from public database. These patient-specific, “knowledge-based” networks will be utilized to train Machine Learning algorithms such as, Graph Convolutional Networks. Ultimately, a fine-tuned, decision-making, knowledge-based software will be implemented for predicting “extremely high risk” CVD patients, as well as their response to treatment. PoCCardio-SB will also develop a digital diagnostic protocol and demonstrate its usability at the PoC. This will include a user-friendly interface as well as the backend SB software. PoCCardio-SB will then integrate this diagnostic protocol with the POC device for improved diagnostic assessment.

Keywords: artificial intelligence,artificial neural networks,systems bioinformatics
Philosophy of Dark Energy (PhilDarkEnergy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The PhilDarkEnergy project proposes that the most dominant ingredient of our universe, dark energy, undermines the widely held assumption of a strict ontological trichotomy between spacetime, matter and constants of nature. Dark energy exhibits aspects of all three categories, rather than falling neatly into exactly one category. The project will study the wide-ranging and far-reaching consequences of this blurred categorisation of dark energy for major debates in philosophy---in particular: the substantivalism-relationalism debate about the metaphysics of spacetime and matter, scientific realism vs. scientific anti-realism, and conventionalism---as well as for theory development in cosmology. This project will take place at the University of Utrecht, the Netherlands, and provide the fellow Dr. Niels Martens with additional training, skills and knowledge in the fields of philosophy of dark energy and philosophy of cosmology more broadly. This will consolidate his academic expertise, independence and networks, with the goals of providing him the skills and expertise needed for a permanent academic position in the EU and playing a leading role in developing and promoting the new field of philosophy of cosmology in the EU.

Keywords: philosophy of cosmology,metaphysics of science,semantics of scientific concepts,naturalised metaphysics within the analytic tradition
Bridging the Migration and Urban Studies Nexus (BROAD-ER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Türkiye,Netherlands,Spain
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 1422906.25
EU funding (EUR): 1422906.0
Participants: 3
Project status: SIGNED

BROAD-ER aims at building a Research Excellence Network which will foster interdisciplinary research and education at the nexus of migration and urban studies. The complementary knowledge, skills, and expertise of two top-class universities, UvA and UPF will be leveraged alongside their structured institutional capacity, to turn KU’s weaknesses into strengths. BROAD-ER will reinforce MiReKoc, leading Turkish institution in the migration field, position and develop its scientific, technological, and development-driven management capacities. The collaboration of these 3 universities aims at closing the research gap within the ERA by establishing innovative and interdisciplinary approaches while also increasing Research & Innovation capacities in Turkey in pivotal emergent fields namely migration and urban studies. BROAD-ER aspires for KU to become an important regional Centre of Excellence for South-Eastern Europe and enhance its collaboration with ERA countries. It will achieve these objectives through diverse activities focusing on research knowledge transfer, enhancing KU’s research capacity and a developing a comprehensive sustainability strategy. BROAD-ER will offer scientific and research management training activities to researchers including research proposal management, key transferable skills (ethical issues, diversity, equity and inclusion, scientific outreach, entrepreneurship, technology transfer, etc.) while addressing research excellence in the project’s fields. The training plans will be complemented with mobility activities allowing the establishment of networking structures and increasing KU’s internationalization. BROAD-ER will result in multiple (joint) publications in high impact top-tier journals, an increased capacity to attract research funding and undertake proposal management and an updated open and transparent recruitment process for researchers.

Keywords: research excellence mobility capacity building migration cities urban politics
Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffolds (MagDock)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This project is focused on the design, the production, the characterization, and the proposal for future commercialization of 3D modular co-culture systems, specifically designed to recapitulate the physio-pathological microenvironment of brain tumor. The key technology at the base of the proposed project is the design of magnetic microscaffolds and their fabrication through two-photon polymerization (2pp), a disruptive mesoscale manufacturing technique that enables low-cost obtainment of microstructures with nanometric resolution, characterized by unprecedented levels of accuracy and reproducibility. A microtubular structure scaffolding endothelial cells and connected to a fluidic system will be exploited to mimic the blood-brain barrier: this biohybrid device will be the base for the assembly of ferromagnetic “microcages” hosting glioblastoma cells, and will be provided with docking systems for superparamagnetic “microcages” carrying undifferentiated and differentiated neuronal progenitor cells. This approach represents a disruptive innovation with respect to other 3D models available in the literature, as it will allow a faithful recapitulation of the complex glioblastoma microenvironment through a platform that can be very easily handled in any laboratory. High-throughput screenings of brain drugs and in vitro testing of the efficacy of different anticancer therapies are envisaged upon successful accomplishment of the project, leading to a pioneering generation of flexible multi-cellular platforms easily adaptable to the mimicry of different pathological conditions.