Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next-generation Detection of Antigen Responsive T-cells (nextDART)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1499070.0
EU funding (EUR): 1499070.0
Participants: 1
Project status: CLOSED

Our current ability to map T-cell reactivity to certain molecular patterns poorly matches the huge diversity of T-cell recognition in humans. Our immune system holds approximately 107 different T-cell populations patrolling our body to fight intruding pathogens. Current state-of-the-art T-cell detection enables the detection of 45 different T-cell specificities in a given sample. Therefore comprehensive analysis of T-cell recognition against intruding pathogens, auto-immune attacked tissues or cancer is virtually impossible. To gain insight into immune recognition and allow careful target selection for disease intervention, also on a personalized basis, we need technologies that allow detection of vast numbers of different T-cell specificities with high sensitivity in small biological samples. I propose here a new technology based on multimerised peptide-major histocompatibility complex I (MHC I) reagents that allow detection of >1000 different T-cell specificities with high sensitivity in small biological samples. I will use this new technology to gain insight into the T-cell recognition of cancer cells and specifically assess the impact of mutation-derived neo-epitopes on T cell-mediated cancer cell recognition. A major advantage of this new technology relates to the ability of coupling the antigen specificity to the T-cell receptor sequence. This will enable us to retrieve information about T-cell receptor sequences coupled with their molecular recognition pattern, and develop a predictor of binding between T-cell receptors and specific epitopes. It will ultimately enable us to predict immune recognition based on T-cell receptor sequences, and has the potential to truly transform our understanding of T cell immunology. Advances in our understanding of T cell immunology are leading to massive advances in the treatment of cancer. The technologies I propose to develop and validate will greatly aid this process and have application for all immune related diseases.

Keywords: t cell detection,mhc multimers,multiplex,technology development,cancer,mutation derived antigens,neo epitope mapping,tcr sequencing,prediction algorithms
SAFER Level Crossing by integrating and optimizing road-rail infrastructure management and design (SAFER-LC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Norway,Greece,Türkiye,Finland,Greece,Belgium,Hungary,France,France,France,France,France,France
Call: Transport infrastructure innovation to increase the transport system safety at modal and intermodal level (including nodes and interchanges) (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 4888927.0
EU funding (EUR): 4888927.0
Participants: 20
Project status: CLOSED

Over the past few years, there is one person killed and close to one seriously injured every day on level crossings. Therefore SAFER-LC aims to improve safety and minimize risk by developing a fully-integrated cross-modal set of innovative solutions and tools for the proactive management and design of level-crossing infrastructure. These tools will enable road and rail decision makers to find even more effective ways to detect potentially dangerous situations leading to collisions at level crossings, prevent incidents at level crossing by innovative design and predictive maintenance methods, and mitigate the consequences of incidents/disruptions due to accidents or other critical events. The project will focus both on technical solutions, such as smart detection services and advanced infrastructure-to-vehicle communication systems and on human processes to adapt infrastructure design to end-users and to enhance coordination and cooperation between different stakeholders from different transportation modes. The project will first identify the needs and requirements of rail-road infrastructure managers and LC users and then seek to develop innovative smart detection and communication systems and adapt them for use by all types of level crossing users. A series of pilot tests across Europe will be rolled out to demonstrate how these new technological and non-technological solutions can be integrated, validate their feasibility and evaluate their performance. The project will deliver a bundle of recommended technical specifications (for standardisation), human processes and organizational and legal frameworks for implementation. SAFER-LC will also develop a toolbox accessible through a user-friendly interface which will integrate all the project results and solutions to help both rail and road managers to improve safety at level crossings.

Keywords: safety,prevention,smart detection,maintenance,level crossing,gnss,modelisation,communication system,human machine interface,integration,road rail interface,standardization
MINiaturized Electron Optics for Nano-controlled beams (MINEON)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany,Italy,Netherlands,United Kingdom
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-06-01
End date: 2022-01-31
Duration (months): 8.0
Total project cost (EUR): 117142.86
EU funding (EUR): 100000.0
Participants: 4
Project status: CLOSED

Electron microscopy allows scientists to measure and image material properties down to the very atomic scale, bringing to fruition Feynman’s visionary idea that saw in the electron microscope the main instrument for nanoscience. However, its development has been restricted for many years to improving spatial and energetic resolution, through the adoption of bulky sets of magnetic lenses and multipoles. This approach has begun to feel limiting - since cross-fertilisation with light optics has shown the many possibilities hidden in the newly-acquired capacity to perform electron beam shaping. In the course of the Q-SORT FET project, we devised an innovative approach to electron beam shaping based on MEMS technology and complex analogue control of the device. MINEON will further validate the design of a MEMS-based spiral phase plate, based on the above approach. Crucially, we will also conduct market surveys, cost modelling, and extensive dissemination targeted at the intended user and funder communities, with the aim of attracting and probing the interest of prospective users and investors. Compared to standard electron optics, this approach is revolutionary because the setup is significantly simpler, more compact, much more flexible, enabling moreover the achievement of very unconventional phase effects. The entailed MEMS technology is of further future commercial interest because it enables many other possible types of beam shaping devices, which could address aberration correction, better material-free Zernike phase plates, multipole analysis of fields in a sample, computational ghost imaging. At the end of this project: - a series of working prototypes of the device and a pilot application for its more effective exploitation will be available - the market potential of the device will have been assessed - its existence will have been disseminated and advertised within the target communities - the cost & revenue model for its production will have been determined.

Keywords: transmission electron microscopy,beam shaping,vortex beam,mems,electron optics
Biogas production from non-food lignocellulosic biomass waste. (BioFuel Fab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

THE PROBLEM. In June 2018 the EU institutions agreed on a new Renewable Energy Directive for the next decade, including a legally-binding EU-wide target of 32% for renewable energy by 2030 and indicating a biogas production of 50 billion m3 per year as a crucial milestone in achieving this goal. But, yearly biogas production growth rate is on a steady decline, due to the stringent regulations imposed by EU that fix thresholds in the use of energy crops and food-derived biomasses as feedstock for biogas generation plants (mainly Anaerobic Digestion - AD). On the other side, lignocellulosic materials are still not properly exploited since woody wastes are largely unaffected by digestion, as most anaerobic microorganisms are unable to break down lignin. As a consequence, biogas operators cannot use the most available no-food derived raw material in their plants. THE TECHNOLOGY. Finrenes has developed BioFuel Fab, an energy self-sustainable and versatile solution able to make biogas production from lignocellulosic wastes economically profitable and environmentally sustainable. This is achieved thanks to a proprietary high-temperature and high-pressure pretreatment process that makes woody waste suitable for anaerobic digestion. Performances are disruptive: the digestion process speed is increased up to 75%, empowering the AD plant capacity by 3 times. The innovation allows to reach a profitability of biogas production from lignocellulosic waste material to be comparable with energy crops and makes convenient to convert the existing biogas plants using energy crops as feedstock to a BioFuel Fab fed by woody wastes, with a payback for the investment of 2.5 years.

Keywords: steam explosion,lignocellulosic waste,biogas plant retrofit,non food source
Innovative technology for the detection of enzyme activity in milk (FORMILK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Hungary,Hungary,Slovakia,United States,Canada
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 1323000.0
EU funding (EUR): 1228500.0
Participants: 10
Project status: CLOSED

The proposal is focused on the development of novel methods of detection of activity of enzymes, such as plasmin and lactase, important for milk industry and for lactose-free diet. Six experienced academic/research institutions, two SMEs, one governmental business company and one manufacturing company from 3 EU member states (Slovakia, Hungary, Ireland), USA and Canada will be involved in the research, development and validation. The main focus will be on application of high-resolution ultrasonic spectroscopy, surface acoustic and electrochemical methods involving nanofabricated surfaces for detection of enzyme activity in volume and at the surfaces. The output of the project will be the novel analytical assays and electrochemical sensor applicable in dairy farms and analytical laboratories, staff exchange between academic institutions and SME, training of the students in novel analytical methods and sensor developments in a world leading laboratories. The optimised enzyme based technologies for efficient control of levels of lactose in milk and milk based drinks will be one of important results of project, which could be commercialised by the project industrial participants. The organisation of training schools, workshops and transfer of novel technology will be among priorities of this proposal.

Keywords: plasmin,lactase,biosensor,high resolution ultrasonic spectroscopy,surface nanofabrication,milk analysis
aDvanced sOcial enGineering And vulNerability Assesment Framework (DOGANA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Israel,Austria,Romania,Switzerland,Belgium,Belgium,Greece,Greece,France,France,Portugal,Denmark,United Kingdom,Portugal
Call: Risk management and assurance models (H2020-DS-2014-1, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 5808217.13
EU funding (EUR): 4599806.38
Participants: 20
Project status: CLOSED

The advent of Social Networks has made both companies and public bodies tremendously exposed to the so-called Social Engineering 2.0, and thus prone to targeted cyber-attacks. Unfortunately, there is currently no solution available on the market that allows neither the comprehensive assessment of Social Vulnerabilities nor the management and reduction of the associated risk. DOGANA aims to fill this gap by developing a framework that delivers "aDvanced sOcial enGineering And vulNerability Assessment". The underlying concept of DOGANA is that Social Vulnerabilities Assessments (SVAs), when regularly performed with the help of an efficient framework, help deploy effective mitigation strategies and lead to reducing the risk created by modern Social Engineering 2.0 attack techniques. Two relevant features of the proposed framework are: i) the presence of the "awareness" component within the framework as the cornerstone of the mitigation activities; ii) the legal compliance by design of the whole framework, that will be ensured by a partner and a work package explicitly devoted to this task. Moreover, the outcomes of the project are also expected to provide a solid basis to revise the insurance models for cyber-attacks related risks, thanks to the involvement of 2 strong DOGANA partners in this area of activity. The project will be implemented by a consortium of 18 partners, from 11 different countries, including users, technology providers of whom 3 are major world-wide cyber-security solutions market leaders as well as legal and psychological expertise. An extensive field trial plan enables the testing of the DOGANA platform with six users (4 partners and 2 supporting users) operating in the critical areas of energy, finance, transport, utilities, and public authorities. DOGANA has also created a unique consortium with a world-wide scope.

Keywords: social vulnerability assessment,cyber risks
Payload Universal Geostationary Interface (PLUGIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: France,Netherlands,United Kingdom
Call: In-Orbit demonstration/Validation (IOD/IOV) (H2020-COMPET-2014, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 384601.25
EU funding (EUR): 384601.0
Participants: 3
Project status: CLOSED

Getting flight heritage for innovative space technologies can be a challenge. While options exist for flying in Low Earth Orbit, few opportunities exist for flying outside the Van Allen belts, especially on the Geostationary orbit where are located the majority of commercial satellites. The PLUGIN project, or PayLoad Universal Geostationary Interface, aims at developing an open standard for hosting innovative packages as passenger payloads on-board commercial satellites. PLUGIN will propose a generic approach, including technical interface requirements and implementation schedule. PLUGIN will also present the business models for hosting such payloads on commercial spacecraft and associated contracting principles, together with a list of opportunities. Airbus Defence and Space (Formerly Astrium) is the leading European manufacturer of GEO communications satellites with 4 launchs per year to GEO orbit, and as such is in the perfect position to promote such initiative. Developing PLUGIN will benefit the whole European industry, by providing a recurring access to GEO orbit. Developing PLUGIN will also improve Airbus DS commercial offers. Airbus DS is teaming with ISIS and SSTL., 2 innovative industry leaders. The combined experiences and mindsets of the 3 companies will allow to assess the whole variety of requests for IOD/IOV in GEO and GTO orbits. The PLUGIN project will be structured around 2 groups : an Advisory Group and a Passenger Representative Panel. The Advisory Group will help the PLUGIN team to propose solutions commercially and technically acceptable by the various stakeholders of the industry. Participants will be ESA, satellite operators and insurers. The Passenger Representative Panel will focus on technical interfaces. The panel will include space hardware manufacturers from various European countries, both large companies, SMEs, and research labs. PLUGIN outcomes will be made public and available to the whole European Industry.

Keywords: hosted payload,geo orbit,gto orbit,satcom,interface,standardisation
Christians among Muslims in Medieval Egypt (CaMMEgy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The CaMMEgy project aims at studying the adaptation processes of the Coptic Christian population after the Arab conquest of Egypt (642 CE) under an innovative angle. It will focus on discourse strategies set up by members of this community in order to claim and reinforce a favourable position in a social and territorial context that was gradually reorganized by Muslim rulers. The analysis will be based on data extracted from two largely understudied textual corpuses that are rarely mobilized together. The first corpus is the Coptic-Arabic historiography and is constituted by historical texts written in Arabic in a Coptic ecclesiastical milieu after it had been arabicized, from the 11th century onwards. The second corpus – papyrological sources – consists mainly of fiscal, legal and epistolary documents, mainly written in Arabic (but also Greek and Coptic). As products of daily interactions between the various members of the Medieval Egyptian society, they will allow to assess the historical reliability of data coming from the first corpus and to consequently highlight the abovementioned strategies. The research will be interdisciplinary and will combine the historical approach, led by Prof. Mathieu Tillier (the supervisor), with the perspectives of textual criticism, (socio)linguistics and literary analysis, provided by Dr. Perrine Pilette (the experienced researcher), at the Université Paris-Sorbonne. Next to peer-reviewed articles that will be uploaded on an open-access repository at the date of publication, one of the main outputs of the CaMMEgy project will be intended for the use of both the academic and general public: new geo-historical maps of Egypt and the Coptic territory – real or purported – will be drawn and uploaded on an open-access web platform.

Keywords: islamic history,christian muslim relationships,religious identities,coptic arabic historiography,arabic papyrology,coptic studies,historical geography
Abiotic factors of diversification in tropical alpine ecosystems. (TropAlp)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: SIGNED

To mitigate the effects of the current biodiversity crisis – the rapid loss of species and ecosystems – we have to understand how species evolve and how diversity is assembled. Physical distance and ecological differences can influence gene flow among individuals of a species in different ways, including the emergence of new species. As such, the evolution of diversity is often driven by geographic isolation and environmental adaptation, but the relative contribution of these processes on species diversification is not well understood. TropAlp aims to study the dynamic interplay of these two processes in driving the evolution of plant diversity to gain a better understanding of the abiotic factors fueling diversification. I will focus on two biodiversity hot-spots, the tropical alpine environments of East Africa and South America, that show differences in diversity among lineages and regions. Both ecosystems are considered island-like with similar climatic conditions but are isolated from their tropical surroundings. The key difference between them is the extent of isolation between mountain peaks. This difference permits investigating the factors that cause variation in diversity using multiple plant lineages and will contribute to a generalized and more global understanding of the evolution of diversity. The objectives of this action are (1) to delimit species; (2) to elucidate the interplay of geography and environment on diversification, and (3) to compare differences in diversity and its causes across the two continents. TropAlp enables me to apply modern phylogenomics and population genomics with comparative analyses, model-based approaches, and bioinformatics. While I have expertise in the latter, comparative phylo- and population genomics are the expertise of the host laboratory. This action will provide me with a modern skill set to become an independent, critical thinking researcher and will enhance my career chances.