Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Post-discharge malaria chemoprevention in children with severe anaemia in Benin, Kenya, Malawi and Uganda: Formative and implementation research for policy decision making and implementation (PDMC Saves Lives)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Kenya,Uganda,Malawi,France,United Kingdom,Benin
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2026-12-31
Duration (months): 42.0
Total project cost (EUR): 4531137.01
EU funding (EUR): 4531137.0
Participants: 8
Project status: SIGNED

Background: Young children in sub-Saharan Africa are at high risk of severe anaemia, associated with high mortality. Children who have recently recovered from severe anaemia in malaria-endemic areas remain at high risk of mortality for about 3-6 months after hospital discharge. Three months of post-discharge malaria chemoprevention (PDMC) has recently been shown to reduce hospital readmissions by 53% and post-discharge deaths by 77%. WHO now recommends PDMC in all highly malaria-endemic areas of Africa. However, the optimal strategies for how to deliver PDMC are not yet clear. Objective: To undertake implementation research and translate results into national policy guidelines to promote PDMC uptake into clinical practice so that vulnerable children have access to life-saving medicines. Study design: i) Formative research in two countries in the process of adopting PDMC (Malawi and Uganda) and two, not yet (Kenya and Benin), to identify key research questions for PDMC implementation. ii) Two implementation trials (Benin and Kenya, N=1,824) in recently discharged children following recovery from severe anaemia, co-designed with national stakeholders, will evaluate at least two PDMC delivery strategies involving community-health workers and automated SMS reminders. The primary outcome will be adherence. Secondary outcomes include clinical and cost-effectiveness, and acceptability and feasibility. Interdisciplinary studies: Acceptability and feasibility; Cost-effectiveness; Policy analysis. Timeline: 42 months: 9m preparation/formative research, 18m trial implementation, 6m analysis + 9m dissemination/exploitation and PhD completion. Impact: The project is designed to provide evidence to support PDMC implementation. Partners: Institut De Recherche Pour Le Developpement, France (coordinating partner); LSTM, UK ; EPICENTRE, France; Institut de Recherche Clinique du Benin; Training and Research Unit of Excellence, Malawi; Makerere Uni, Uganda; Kenya Medical Research Institute, Kenya

Keywords: malaria,anaemia,antimalarials,artemisinins,acceptability,adherence,caregivers,chemoprevention,child,community health workers,service delivery,health policy,health economics
Ocean-ICU Improving Carbon Understanding (OceanICU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Norway,Denmark,Belgium,Spain,France,Netherlands,Germany,Ireland,Portugal,Türkiye,Poland,United Kingdom,Italy,Sweden
Call: Understanding the oceanic carbon cycle (HORIZON-CL6-2022-CLIMATE-01, 2022)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 13094052.25
EU funding (EUR): 13094052.25
Participants: 31
Project status: SIGNED

The Ocean plays a crucial role in the global C cycle, taking up approximately 25% of the CO2 we emit to the atmosphere, and thus slowing the rate of climate change. The future trajectory of this sink will affect the timing and intensity of the modifications to human processes that we need to undertake in order to stabilise atmospheric CO2 at 450ppm. Our ability to measure and model this sink is limited (evidenced by significant discrepancies between measured and modelled C uptake) with the current frontier area of research being a suite of biological processes related to higher trophic level behaviour within the so called biological C pump. This involvement of higher organisms suggests that human activities (fishing, energy and mineral extraction) has the capacity to affect the ocean C sink however we lack the ability to quantitatively link direct human pressures and ocean C storage. Ocean ICU will measure these key processes and evaluate their overall significance, transferring those that are important into models that inform the IPCC process and in this way contribute to resolving the observed model data mismatch of Ocean C sink estimates. We will take this message directly to the COP in support of the ambition the UNFCCC has to include the ocean C sink in the global stocktake. We will use the fundamental knowledge we acquire around biological systems to evaluate the ability of human interventions in the ocean to alter the carbon cycle and produce management tools that allow the tension between resource extraction and C storage to be addressed. This component will involve extensive dialogue with end users and stakeholders and lead to a Decision Support Tool that will constitute a major contribution to our ability to deliver the Green Deal by allowing us to ask questions around how to manage fisheries and resource extraction in a changed ocean in 50 years time.

Keywords: fisheries,deep sea mining,decision support tool,machine learning,green deal
REVERT Regeneration as a Vulnerable State for Microbe-Driven Injury and Tumorigenesis (REVERT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2028-01-31
Duration (months): 61.0
Total project cost (EUR): 1426714.0
EU funding (EUR): 1426714.0
Participants: 1
Project status: SIGNED

Tissues with high turnover are hierarchically organized and rely on long-lived stem cells that are protected by a variety of mechanisms. In the gastrointestinal tract, highly active stem cells are located in the base of crypts, where differentiated cells shield them from environmental threats. It has recently emerged that mucosal injuries initiate regenerative repair programs that promote a disruption of cellular hierarchies and reversal of differentiated cells back to the proliferative stem cell state. While this remarkable plasticity enables rapid injury repair, I propose that the recruitment of differentiated cells to the stem cell pool represents a critical event for the accumulation of genetic and epigenetic alterations because differentiated cells are more exposed to the environment and less equipped to repair DNA damage. Particularly in the colon with its dense and potentially harmful microbiota, injury-driven de-differentiation may be linked to loss of cell functions that control the microbiota and direct exposure of “de novo stem cells” to bacteria and their genotoxic virulence factors. REVERT will investigate the long-term consequences of such transient interactions on molecular, cellular, and tissue levels and explore the impact of the regenerative state on mucosal microbial ecology and function. REVERT will combine stem cell biology approaches such as, lineage tracing, organoids, and assembloids with microbiology techniques such as gnotobiotic infection models, and integrate complex systems biology technologies to build up a picture of dynamic tissue responses to injuries and the ability of microbes to interfere with them. REVERT has the potential to establish fundamental new knowledge of principles that govern mucosal integrity and reveal its vulnerabilities in the context of injury. It has the potential to drastically expand our understanding of processes that drive chronic tissue dysfunction and carcinogenesis.

Keywords: microbiota,regeneration,colon stem cells,injury repair,innate memory,carcinogenesis
NESS Dual Hybrid Systems – Cost-effective CO2 solutions to increased Vehicle Electrification and Efficiency (NESS – New Electrified Supercharging System)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 2855226.25
EU funding (EUR): 1998658.0
Participants: 1
Project status: CLOSED

NESS is the most efficient and cost-effective dual hybrid (electric- fuel) solution and reduces 13-18% vehicles’ fuel consumption, CO2- and NOx emissions. It also converts fossil-fuelled gasoline- and diesel cars into Hybrid Electric Vehicles (H-EVs) ready for 100% climate neutral renewable fuels, such as e-fuels, H2 gas and 2nd gen biofuels. NESS converts both new- and existing cars as a plug n’ play retrofit product conversion. It consists of an add-on component that goes attached to the engine’s alternator and turbocharger, forming a fully modular solution adaptable to all types of engine- and vehicle sizes. The savings are attained thanks to various functionalities that reduce the consumption of the vehicle in different ways depending on the drive mode the vehicle runs; exhaust gas energy recovery works at cruising, regenerative breaking when breaking, energy boosting functions at accelerating and stop & start functions when the vehicle is stationary.

Keywords: hydrogen gas driven vehicles,fossil fuel free vehicles,cost effective vehicle electrification,waste heat energy recovery,dual hybrid systems,renewable and electro synthetic fuels
Digital Assistants for Reducing Workload & Increasing collaboratioN (DARWIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Czechia,France,Germany,Slovenia,Belgium,Italy
Call: Fast Track Innovation and Uptake Artificial Intelligence for Aviation (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-08-31
Duration (months): 39.0
Total project cost (EUR): 5163172.25
EU funding (EUR): 3460077.0
Participants: 6
Project status: SIGNED

DARWIN ambition and vision is to develop technology enabling AI based level 4 automation for cockpit and flight operation as a key enabler for SPO (Single Pilot Operations) and demonstrate the same (or higher) level of safety with same (or lower) workload as operations with a full crew. It will bring solutions that will help the market maintain operational efficiency with increased complexity and routing flexibility, which are expected by the emergence of drones and air taxis. The results will support the commercial and operational viability of those new airspace users, even with the forecasted pilot shortage and growing environmental concerns. AI-based automation will come with its own challenges that need to be addressed to keep the high safety standards for the next generation of automation. One of the biggest challenges is to facilitate the cooperation between humans and AI. The DARWIN project builds upon the available technology base in AI and leverages the partners’ excellent position in the aviation supply chain to address the need for scalable, interconnected, and highly automated eMCO (Extended Minimum Crew Operations) and SPO operation concepts as one of the inherent foundational building blocks of the Digital European Sky (SESAR ATM Master Plan Phase D). The system will consist of 3 core enabling technology layers: 1) Trustworthy Machine Reasoning Platform will provide capabilities for rule-driven, transparent, and explainable decision aiding or decision making. 2) Human-AI Collaboration layer will be implemented on top of the Reasoning Platform. It will provide collaborative capabilities for the pilot interaction with the adaptive automation and assistants to efficiently keep the human-in-the-loop of the workflow in the eMCO or SPO cockpit with the Level 4 automation. 3) Pilot State and Taskload Monitor will provide data to the collaboration layer and automation to adaptively react. The project will deliver a TRL7 system validated in ops environment.

Keywords: human machine teaming,adaptive automation,ai,machine reasoning,pilot monitoring,machine learning
Human - Centric Indoor Climate for Healthcare Facilities (HumanIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Poland,Norway,Germany,Sweden,Finland,Belgium,United Kingdom,Portugal,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2707840.8
EU funding (EUR): 2707840.8
Participants: 18
Project status: SIGNED

Over 4 million hospital patients acquire a healthcare-associated infection (HAI) in the EU each year. Moreover, the global crisis of antimicrobial resistance means that HAI is posing an increasing cost and risk of mortality. There is clear evidence that airflow controls the dispersion and exposure to airborne pathogens and determines the contamination of critical surfaces in the human-centric climate (HCC), which is defined as the microenvironment which surrounds and is close to a human body. This points to a significant need for innovation in healthcare indoor environments to tackle the challenge of infection control, while improving thermal comfort and energy efficiency in hospitals. To achieve this, we must both advance the fundamental understanding of how people are exposed to airborne pathogens and develop new tools and techniques to enable effective design and operation of healthcare environments. Specifically, there is a need to understand better the local influence of airflows on particles in HCC; quantify the transient behaviour of airflows and contaminants due to healthcare activities like surgery; develop methods for optimising and adapting ventilation systems to control for risks in different environments like operation rooms and isolation rooms; and develop tools to enable real-time interaction with environments during design and operational phases. Bringing together 8 leading academic teams, 4 healthcare facilities and 8 HVAC industry partners, the HumanIC network aims to build a new approach to hospital environmental design through the concept of HCC and the training of 15 Early Career Stage Researchers to address these needs. HumanIC will create and disseminate fundamental and applied science to improve the knowledge base and innovate new technologies for designing and operating hospital ventilation and thermal systems and for reducing infection risk by at least 30%, meanwhile satisfying requirements of thermal comfort, safety and energy.

Keywords: hospital,patients,operating room,human centric climate,ventilation,airborne pathogen exposure,indoor air quality,modeling,smart tool,monitoring,thermal comfort,energy efficiency
PLAsticity of perception in real and virtual spaCES (PLACES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Australia,United States,Canada,New Zealand,United Kingdom
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 1021857.14
EU funding (EUR): 998200.0
Participants: 13
Project status: SIGNED

Space is fundamental to physical and perceptual reality, but physical and perceptual space are not the same. Perceptual space is created by the brain and plastically formed by the sensorimotor interactions of our body with physical reality. In the digital future, these two spaces are joined by novel spaces experienced in virtual (VR) and extended (XR) reality as these new technologies massively expand in work, pleasure and social interaction. The first aim of PLACES is to understand how sensorimotor interactions in virtual environments shape perceptual space and how this interacts with virtual (VS) and real (RS) space. Secondly, deep and improved knowledge of perceptual mechanisms is essential for the future development of VR as a key digital technology for Europe. To work for the people, VR and XR need to be effective, comfortable, transparent and fair. These aims can only be reached by understanding and accounting for perception in a human-centric manner. Based on these premises, the highly interdisciplinary consortium of PLACES pursues five key objectives: to (1) use cutting-edge VR technology to advance scientific knowledge of the mechanisms of sensorimotor perception and plasticity; (2) use our understanding about spatial perception, gaze control and sensorimotor plasticity to advance VR technology and enhance VR applicability; (3) predict action intentions of users in VR and employ these predictions in advanced user interfaces; (4) understand how long-term usage of VR interacts with perceptual and sensorimotor states in real space and in virtual space; and (5) translate research findings into applied fields in vision aids and social telepresence. Reaching these objectives will put the EU on the map as a leader in perception research and its application in VR. PLACES aims for new frontiers in perception science and its applications, and for a significant impact on the people of the EU.

Keywords: self motion,eye movements,redirected walking,parietal cortex
Luxury and Modern Global Order (LUX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

Whether private-jet carbon emissions, haute couture, or the diamond trade: how we judge luxury is surprisingly closely tied to how we view global order. So what role exactly does luxury play in modern global order? Based on a historical-sociological investigation of the maritime fur trade, the gold rushes, and the World's Fairs, LUX is the first comprehensive study of the nineteenth-century contestation of luxury at the level of global order. It has three objectives: a conceptual history of luxury with a focus on global order; an investigation of practitioners' conceptions of luxury in three case studies; and developing an empirically grounded new theory of "sumptuary ordering," or the policing of luxury as a marker of status in global order. Extant work identifies a break in the late eighteenth century, from suspicions of luxury as a vice to a modern embrace of luxury as a virtue. Yet what this embrace entailed in practice, and what kind of global order the pursuit of luxury was understood to require, is unclear. This gap is surprising, since the link between luxury and the power, status, and imperial expansion of states had long been considered obvious by thinkers from Plato to Thomas More to Mary Birkett. Further, how practitioners involved in the creation of luxury markets–many of them preludes to colonisation–understood global order is unexplored. My innovation is twofold: I study conceptions of luxury among practitioners rather than philosophers; and I move from histories of consumption to luxury-framed hierarchies between nations. This invigorates debates on historical global orders and hierarchy. Connecting IR and history with current debates on colonial legacies and sustainability, LUX comprises archival research and theory-building, but also intervenes in wider debates on the future of luxury.

Keywords: international relations,imperialism,globalisation,global order
ROBUST PEMFC MEA DERIVED FROM MODEL-BASED UNDERSTANDING OF DURABILITY LIMITATIONS FOR HEAVY DUTY APPLICATIONS (PEMTASTIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Denmark,Belgium,France,Switzerland,United States
Call: Innovative and optimised MEA components towards next generation of improved PEMFC stacks for heavy duty vehicles (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2748608.75
EU funding (EUR): 2748608.5
Participants: 11
Project status: SIGNED

The R&D project PEMTASTIC aims to meet the key technical challenges to increase durability of MEAs for HD applications. These challenges are approached with a combination of model-based design and the development of a durable CCM using innovative materials tailored for heavy duty operation at high temperature (105°C). The quantitative targets correspond to a durability of 20,000 hours maintaining a state-of the art power density of 1.2 W/cm2@0.65 V at a Pt loading of 0.30 g/kW. Truck mission profiles will be analyzed (Symbio) in order to define relevant FC operation protocols and stressors. Degradation tests will be carried out in differential cells and will be assisted by physical-chemical material characterization to assure well defined data required for parametrization of degradation models (CEA, DLR). A combination of micro- and mesoscale models as well as 1D and 2D cell models (ZHAW, DLR) will capture the impact of material parameters on performance and durability and will address all material and CCM parameters which will be iteratively adapted by industry partners. The materials which will be implemented and adapted are advanced corrosion resistant supports (Imerys) combined with a novel catalyst deposition technique (Heraeus) to mitigate for ECSA loss. Prototype Nafion ionomers and membranes with high conductivity in dry conditions will be used (Chemours). Eventually, an improved cathode catalyst layer will be designed considering Pt particle size distribution and superior catalyst ionomer interaction (IRD). The selection of a commercial GDL will consider accommodation of a wide range of operating conditions. The final MEA and the concept of model-based MEA development will be validated in a short stack at TRL4 (Symbio). As additional outcomes, implications on system management and on the BoP components will be drawn, and the reduced computational demand for degradation modelling will facilitate fast health assessment and performance prediction.

Keywords: pemfc mea membrane electrode assemblies ccm catalyst coated membrane ccl current collecting layer hdv heavy duty vehicle fc fuel cell h2 hydrogen carbon membrane ionomer