Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Marine chemical glycobiology: a molecular understanding of the carbon cycle and bioactive sulfated marine glycans (MARINEGLYCAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Marine microalgae sequester as much CO2 into carbohydrates as terrestrial plants. However, the marine carbon cycle is currently not understood in molecular detail. MARINEGLYCAN seeks to explore the marine biosphere using an approach rooted in chemical biology & automated glycan assembly (AGA) by inventing new tools for deciphering biological information. I will generate an assortment of tools: glycan microarrays, fluorescently labelled polysaccharides (FLAPS), Förster resonance energy transfer (FRET) probes, & activity-based probes (ABP) working at the Max Planck Institute (MPI) of Colloids & Interfaces in collaboration with the MPI for Marine Microbiology to allow the systematic study of the flow of carbon–from the level of individual enzymes to interdependent communities. These tools will be used to discover the bioactive epitopes of sulfated marine glycans–known to have anti-viral, anti-cancer, & neuroprotective properties. A new continuous flow photocatalytic process to access fluorinated glycans will be developed in the context of the project. While gaining a broad range of scientific techniques including AGA & techniques used in marine glycobiology, I will gain & develop my transferable skills & expand my network. All allowing me to have a successful career in both business & academia. These skills will be obtained through workshops provided by the Max-Planck Academy, managing of PhD students & mentoring by Prof. Seeberger. The knowledge & skills I gain working on MARINEGLYCAN will provide me with the skill set to collaborate with Industry–while also carrying out basic scientific research. MARINEGLYCAN seeks to gain a better understanding of the flow of carbon in the marine environment, allowing Europe to advance towards a green circular economy. With the potential to pave the way for the design & development of new sustainable biomaterials, biocatalysts, & medicines. MARINEGLYCAN is in line with the European Commission's & UN sustainable development goals.

Keywords: chemical biology,glycans,bioeconomy,marine
RADiation and reliability challenges for electronics used in Space, Avionics, on the Ground and at Accelerators (RADSAGA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Italy,Norway,Belgium,Finland,Sweden,Belgium,Switzerland,Switzerland,France,France,France,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 3882975.78
EU funding (EUR): 3882975.78
Participants: 25
Project status: CLOSED

Reliability and radiation damage issues have a long and important history in the domain of satellites and space missions. Qualification standards were established and expertise was built up in space agencies (ESA), supporting institutes and organizations (CNES, DLR, etc.) as well as universities and specialized companies. During recent years, radiation concerns are gaining attention also in aviation, automotive, medical and other industrial sectors due to the growing ubiquity and complexity of electronic systems and their increased radiation sensitivity owing to technology scaling. This raises the demand for dedicated design and qualification guidelines, as well as associated technical expertise. Addressing open questions linked to respective qualification requirements, the proposed training network “RADiation and Reliability Challenges for Electronics used in Space, Aviation, Ground and Accelerators” (RADSAGA) will for the first time bring together industry, universities, laboratories and test-facilities in order to innovate and train young scientists and engineers in all aspects related to electronics exposed to radiation. The expertise of the space and avionics sectors will be complemented with new and unique test facilities, design and qualification methodologies of the accelerator sector, promising for other application areas. Driven by the industrial needs, the students will be trained by established specialists in all required skills, and acquire expertise through innovative scientific projects, allowing to: (i) push the scientific frontier in design, testing and qualification of complex electronic systems for mixed field radiation environments (ii) establish related courses to train future engineers/physicists; and (iii) issue design and test guidelines to support industry in the field, protecting European competitiveness when radiation effects become as important as thermal or mechanical constraints for the aviation, automotive and other industrial sectors.

Keywords: radiation effects,space,aviation,ground,accelerator,reliability,radiation facilities,monitoring,qualification,integrated circuit,internet of things,radiation hardening,single event effects
Accessing Nucleosomal DNA (NucEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 2100929.0
EU funding (EUR): 2100929.0
Participants: 1
Project status: SIGNED

Transcription factors (TFs) regulate gene expression and govern cell identity. In chromatinised genomes TF binding sites are frequently encapsulated in nucleosomes, which severely restrict access. While specialised pioneer factors have been proposed to bind to these sterically hindered sites, the exact mechanism by which these factors access nucleosomes remains unknown. A number of biochemical models have been put forward that would allow DNA sequence read-out, these include: (i) TFs compatible with the nucleosome architecture, (ii) alternative, partial, DNA motifs that render TFs nucleosome compatible, (iii) exposure of DNA binding sites through histone-nucleosome breathing dynamics, or (iv) remodelling of the histone core by TF binding. Despite being a fundamental question in genome regulation, no structural rationale is currently available for any of these proposed mechanisms. In unpublished work, we developed a novel biochemical assay allowing to simultaneously investigate all DNA registers on a nucleosome for TF access. This tool enabled us to solve the 3.8 Å structure OCT4/SOX2 bound to a nucleosome revealing the unexpected binding modes these TFs employ to engage nucleosomal binding sites (unpublished). Building on this novel biochemical workflow, we propose to solve additional structures of TFs compatible with the nucleosome-architecture and of those TFs suspected to bind to the ends of nucleosomal DNA. By dissecting multiple structures with diverse DNA binding domains in vitro and in cells, we wish to understand general principles of how DNA sequence motifs are being read-out at different sites on a nucleosome. The key questions we wish to address are: How does the location of a TF motif on a nucleosome impact affinity and/or the binding mechanism? Can TF binding remodel the nucleosome architecture? How do arrays of nucleosomes impact TF accessibility to DNA?

Keywords: transcription factors,nucleosome,nucleic acid,protein interactions
Unlocking the Full Power of Wind (TwingTec)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wind energy represents 25% of the new global installed electrical generation capacity, however, ground-based wind turbines (WTs) are estimated to supply only 18% of the world’s electricity by 2050, as current wind energy systems have major challenges limiting their commercial applications: heavy dependence of productivity on the prevailing weather and huge material needs, entailing low capacity factors, difficult and expensive transportation, troublesome installation and high costs. Our disruptive technology -Airborne Wind Energy, AWE- can harness the energy of the wind at high altitude to provide greater power output than conventional WTs, much higher capacity factors, exceeding 60% in good sites, using 95% less material needs per MW and avoiding all the associated issues. It replaces most of a conventional WT, namely the tower, blades and foundation by a much lighter and less expensive flying tethered aircraft. The reason for seeking wind at high altitude is that the wind blows faster and more constantly. Although conventional WTs are simply not viable in most areas, TwingTec can exploit high steady winds over most of the land area of the Earth. We firstly target the off-grid market relying on diesel generation, for the perfect combination of high energy costs and mobility requirements met by TwingTec: industrial off-takers and remote communities. LCOE estimations are €100-200/MWh, much cheaper than diesel generation. In the medium term, our products will address bigger scale promising markets as the off-shore segment in EU Islands, drastically decreasing LCOE. Unlike competitors, we have a proven technology, demonstrating our solution for automated Vertical Take-Off and Landing using integrated drone technology -patented-. TwingTec enables 2 business models: 1) OEM: TwingTec units are purchased and transport and installation costs are charged together with an annual O&M fee. 2) Energy as a Service: Off-grid electricity is paid to TwingTec on a per MWh basis.

Keywords: airborne wind energy,portable wind energy generator,wind energy 2 0,off grid supply
Individual Three-dimensional Spatial Auditory Displays for Immersive Virtual Environments (ITS A DIVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

3D spatial auditory displays can provide accurate information about the relation between the sound source and the surrounding environment, including the listener and his/her body which acts as an additional filter.This information cannot be substituted by any other modality (e.g. visual or tactile). Nevertheless, today's spatial representation of audio tends to be simplistic, being multimodal systems currently integrated with simple stereo or surround sound. In IT'S A DIVE extremely innovative techniques for binaural sound rendering will be developed, following a multidisciplinary approach encompassing different research areas such as computer science, acoustics, and psychology. The focus of the research program will be on structural modeling of head-related transfer functions (HRTFs), i.e. a family of state-of-the-art modeling techniques that overcome the current limitations of headphone-based 3D audio systems. The customization of the HRTF model based on the user's anthropometry will grant to any user a low-cost and real-time fruition of realistic individual 3D audio, previously only possible with expensive equipment and invasive recording procedures. The main objective of the research program will be the definition and experimental validation (through subjective psychophysical tests) of a completely customizable structural model for binaural sound presentation, which is today still missing in the literature on spatial audio. The technical focus will be on the exploitation of a vast number of public HRTF databases, including custom controlled acoustical measurements, and of state-of-the-art machine learning techniques in order to customize HRTFs by incorporating prior knowledge on the relation between HRTF features and anthropometry. The research program is expected to represent an innovative breakthrough for a plethora of applications, e.g. personal cinema, teleconferencing and teleoperation systems, electronic travel aids, and computer games.

Keywords: spatial sound
Respecting safe operating spaces: opportunities to meet future food demand with sustainable use of water and land resources (SOS.aquaterra)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-02-28
Duration (months): 69.0
Total project cost (EUR): 1982113.0
EU funding (EUR): 1982113.0
Participants: 1
Project status: SIGNED

Although the human population has quadrupled over the past century, per capita food availability is globally higher than ever - at the expense of environment: scarcity of water and land as well as exceedance of several planetary boundaries. Projected population growth and climate change will further increase the pressure on feeding the planet with sustainably managed natural resources. SOS.aquaterra takes up this challenge by identifying feasible measures to meet future food demand while staying below water and land scarcity thresholds. The project develops novel integrated modelling and data analysis methods to fully exploit the rapidly increasing global open spatio-temporal datasets together with outputs from global agrological and hydrological models. In the proposal, instead of assessing water and land scarcity separately, which is the current practice, the assessments are integrated. The second novelty in SOS.aquaterra is developing an integrated model that combines for the first time the potential of conventional and innovative measures -e.g. yield gap closure, alternative protein sources- towards increased food availability. The feasibility of these measures, within the safe operating space resulting from scarcity assessment, is explored by analogical problem solving and clustering methods. The innovative integration of measures using the latest datasets and modelling tools holds high risks, yet it significantly advances the scientific and technological state of the art to meet food demand with sustainably managed natural resources.

Keywords: water resources,land use optimisation,resource scarcity,food security,global change,mathematical modelling,integrated assessment and modelling,sustainable development
Regulation and Metabolic Engineering of Saponins for use as bio-pesticides. (REMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-11-21
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Insect pests and pathogens cause major losses in agriculture, and there is a critical need to develop novel and sustainable methods to reduce these losses. Plants produce a vast diversity of specialized chemicals that deter antagonist, but in spite of their potential for pest management they are still largely unexplored. We need to understand better how such defence compounds are synthesized by plants and what biotic and abiotic conditions trigger and regulate their production, in order to develop and use them sustainably. The objective of my REMES project is to uncover the genetic and molecular regulation of triterpenoid saponin biosynthesis, using the insect-resistant wild crucifer Barbarea vulgaris as a model system, and explore their use as bio-pesticides. I will 1) characterize transcriptional regulators of the saponin biosynthetic pathway; 2) explore how saponin biosynthesis responds to different functional types of insects and pathogens in B. vulgaris; and 3) manipulate the regulatory responses and production of saponins to assess their potential as sustainable bio-pesticides. In the project, I will take advantage of the experience and state-of-the-art facilities at the host in systems biology, molecular biology, biochemistry, bioinformatics, metabolomics and plant-insect interactions; in turn, I will contribute my own expertise in characterization of transcriptional regulation of specialized metabolism in plants. With the project I will consolidate my career in research whilst also developing important academic and transferrable skills for pursuing a future career in academia. Altogether, the project will improve our understanding of saponin biosynthesis and regulation, which will improve the industrial interest and means to develop crops with modified content of saponins and ecologically appropriate defence reactions, either through classical breeding or genetic engineering.

Keywords: specialized metabolism,plant insect interactions,triterpenes,bio pesticides
European Training Network for the sustainable, zero-waste valorisation of (critical) metal containing industrial process residues (SOCRATES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Finland,Belgium,Belgium,Finland,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 3858940.08
EU funding (EUR): 3858940.08
Participants: 13
Project status: CLOSED

Unlike China, Russia or South Africa, the EU-28 Member States are not in the fortunate position of having vast, easily accessible ore deposits containing valuable metals. However, Europe does have large quantities of secondary industrial residues (tailings, sludges, slags and ashes) that contain sig¬nificant concentrations of both critical and economically important metals. The Euro¬pean Training Network for the Sustainable, zero-waste valorisation of critical-metal-containing industrial process residues (SOCRATES) targets ground-breaking metallurgical processes, incl. plasma-, bio-, solvo-, electro- and ionometallurgy, that can be integrated into environmentally friendly, zero-waste valorisation flow sheets. By unlocking the potential of these secondary raw materials, SOCRATES contributes to a more diversified and sustainable supply chain for critical metals (cf. Priority area 3 in EC Circular Economy Action Plan; COM(2015)614/2). The SOCRATES consortium brings together all the relevant stakeholders along the value chain, from metal extraction, to metal recovery, and to residual matrix valorisation in added-value applications, such as supplementary cementitious materials, inorganic polymers and catalysts. To maximise applicability, SOCRATES has selected four commonly available and chemically complementary residue families: (1) flotation tailings from primary Cu production, (2) Fe-rich sludges from Zn production, (3) fayalitic slags from non-ferrous metallurgy, and (4) bottom ashes from incineration plants. As a basis for a concerted effort to strengthen the EU’s critical-metal supply chain for Ge, In, Ga and Sb, SOCRATES trains 15 early-stage researchers (ESRs) in technological innovation: metal extraction (WP1), metal recovery (WP2), residual matrix valorisation (WP3) and integrated assessment (WP4). By training the ESRs in scientific, technical and soft skills, they are the next generation of highly employable scientists and engineers in the raw-materials sector.

Keywords: critical metals,ionometallurgy,plasma metallurgy,solvometallurgy,electrowinning,extractants,modelling,supplementary cementitious materials,geopolymers,catalysts,exergy
Very high temperature HVDC busbar (180 - 240°) with reliable and cost effective technology (VILB)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Design and Development of a high temperature HVDC busbar (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 668276.25
EU funding (EUR): 497355.0
Participants: 2
Project status: CLOSED

More Electrical Aircraft power distribution systems are increasingly required to operate in harsh environments and increasing voltage (HVDC), including high temperature. The company Auxel (an industrial leader in laminated busbars) & the LSEE Research Laboratory (Electrotechnical Systems and Environment) will conjointly address this topic by developing a technology able to effectively address the challenges of High Voltage, high operating temperature (up to 240°) and controlled lifetime: VILB (Varnished & Impregnated Laminated Busbar) technology. Firstly, VILB is a technological breakthrough as it is based on an entirely new strategy for the insulation of laminated busbars (LBB) (one component of the power distribution systems). Indeed, VILB will replace insulating films, glue and complex assembly processes by a heating press with an impregnation technology using a dielectric resin. This process will make the LBB resistant to higher temperatures (240°) and partial discharge (tiny short circuits appearing during the insulation phase and accelerating the system ageing). Secondly, VILB is a limited risk taking technology as it is inspired by perfectly mature technologies and products widely used for the insulation of electric machines. Thirdly, the potential VILB impacts are way beyond aeronautical sector: VILB could be duplicated in many other applications such as power modules, converters, automotive Industry, etc. Finally, thanks to this simplified process, in comparison with the traditional thermally bonded insulating film on heating press process, the implementation of VILB technology for busbars will result in higher productivity (x 5), lower production costs (from - 10% to - 30%) and energy savings (- 80%). During the project, the busbar will be designed, its performance simulated, the prototypes tested to TRL6 demonstration ending with a “TRL 7 ready” prototype. AUXEL and the LSEE have already co-patented VILB with 2 patent pending applications.

Keywords: laminated busbar,corona resistance,partial discharge inception voltage pdiv,varnished insulation,enamelled varnish,vacuum resin impregnation,low inductance,power electronics