Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Moral Elites: The Historical Positioning of Civil Society Leaders in National Moral Economies (MORALITES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1486924.0
EU funding (EUR): 1486924.0
Participants: 1
Project status: SIGNED

Objective: Conduct a ground-breaking historical-relational comparative study of civil society elites’ integration in and effects on four European countries’ moral economies, explaining diverging paths through career trajectories and position-takings. Question: Why, how, and with what consequences were civil society elites historically integrated into national moral economies? Hypothesis: The position and position-taking of civil society elites since the mid-19th century crucially shaped national moral economies. Motivation and scientific significance: Counters the almost completely neglected historical impact of civil society elites in elite studies, civil society scholarship, welfare state research, and political economy; challenges compartmentalisation of social science through comprehensive theoretical framework; breaks new methodological ground in integrating career trajectory analysis and NLP topic modelling textual analysis; significantly reorients scientific and public understanding of the historical role of civil society elites. Societal value: Strengthens transparency and accountability of civil society elites by pinpointing their historically changing dependencies; enhances the understanding of the role of civil society elites in stabilising and deepening democratic institutions, social policies, and regulation of the economy. Profile of PI: Strong background in historical sociology, civil society research, welfare state research, sociology of religion; strong international network with several European and US American universities; organiser of and presenter at international conferences; ambitious and original academic publishing record highly relevant to the project proposal’s study object and theoretical and methodological approach. Key deliverables: At least three quality journal articles per PhD candidate and two per post doc; two cross-WP theoretical and methodological articles and a cross-WP monograph; two edited volumes or spec

Keywords: elites,civil society,historical sociology,democratisation,social policy,institutionalism,moral economy
SKIN MICROBIAL DEVICES (SKINDEV)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Netherlands,United Kingdom,Germany,Portugal
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2210088.83
EU funding (EUR): 2210088.0
Participants: 6
Project status: SIGNED

The long-term vision and ambition of the SKINDEV consortium is to complement the human skin microbiome with Smart Skin Microbial Devices (SSMDs) in atopic dermatitis (AD) patients and other dermatological conditions as a new non-invasive system for future treatment and monitoring of disease gearing up towards preventive care. This idea and new technology are groundbreaking and radical. SKINDEV aims to make SSMDs generally applicable through innovative technologies like sensing applications in wearables and cameras providing at-home on-demand skin health information. SSMDs will be ideal for early detection and intervention of health hazards. In this Pathfinder project the focus is on interaction at three steppingstones (SS), towards a prototype SSMD with proof-of-concept for the coupling of sensing and actuation in Cutibacterium acnes (C. acnes) for AD-related inflammatory processes: SS1. Systems engineering to create a multi-scale computational model of AD pathophysiology; SS2. Genetic engineering to create sensing and actuation circuits in C. acnes; SS3. Tissue engineering to create a high throughput skin organoid platform for AD. A priority of SKINDEV is to translate technological innovations into proof-of-concept novel devices. SKINDEV is expected to invent such new technologies to i) genetically modify skin microbes, ii) create sensing modules and actuators, and iii) develop pre-clinical skin organoids and computational models for host-microbe interactions. The work plan implements an efficient ‘design, build, test and learn cycle’ to accelerate the achievement of sensing and actuating performance fulfilling relevant physiological roles. Successful achievement of these ambitious goals requires highly integrated interdisciplinary collaborations by scientists working at the forefront of relevant disciplines.

Keywords: skin microbiome,microbial devices,synthetic biology,sensors
Engineering biological timers and their applications (TICK-TOCK Do and Die)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2327816.0
EU funding (EUR): 2327816.0
Participants: 1
Project status: SIGNED

Living cells are endowed with encoded programs that allow them to execute vital tasks and respond to relevant stimuli. The use of analogous (synthetic) programs has an enormous potential, yet we are highly limited in our ability to program cellular actions over time. We rely on precisely-timed human intervention or on molecular oscillators that control repetitive processes, but we are still unable to program cells to autonomously execute custom actions at desired times. I now intend to make a big leap toward this goal by producing control systems (molecular timers) and associated, ready-to-use applications, for the precise and self-sufficient control of cellular actions over time. Specifically, I will engineer timer gene circuits into E. coli that compute time and perform desired actions at specified moments. Timers will be highly programmable, re-usable, and scalable, and I will exploit their potential by using them for different applications, including bioproduction and biosensing. In sum, I will develop the highly-needed, ground-breaking ability to measure and program time in cells. My results will unleash a myriad of new possibilities, both fundamental and applied.

Keywords: synthetic biology,gene circuit,crispri circuit,dynamic circuit,molecular oscillator,molecular clock,molecular timer,cell programming,biocontainment,biocomputing,molecular recording
Plasmodium liver stage schizogony: high replication and genetic diversity (PASSAGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 2467196.25
EU funding (EUR): 2467196.25
Participants: 2
Project status: SIGNED

A world free of malaria is certainly a desirable goal. However, in spite of the significant incidence reduction achieved globally between 2000-2015, malaria still kills a child every minute. The limited understanding of Plasmodium’s biology hampers the development of novel intervention strategies. Upon transmission by Anopheles mosquitos, Plasmodium parasites must reach the liver and infect hepatocytes. Inside a hepatocyte, each parasite replicates into thousands of new erythrocyte-infectious forms, which lead to disease. The parasite biomass generated during the liver stage (LS) of infection is directly associated with malaria severity, but how the parasite achieves such a high replication rate, and the consequences of that, remain utterly unexplored. Notably, Plasmodium replication is unusual. The parasite divides by schizogony, with divisions occurring without cytokinesis and it cannot salvage pyrimidines from the environment, relying solely on nucleotides synthesized de novo. Using a Plasmodium transgenic line specifically designed to study DNA replication throughout parasite development, I unveiled for the first time the temporal dynamics of DNA replication throughout parasite LS and show that Plasmodium’s LS high replication rate is accompanied by DNA damage. Thus, I hypothesize that DNA damage accumulation during LS schizogony is a generator of genetic variability prior to intra-erythrocytic infection. By using a combination of molecular, cell biology and genetic approaches, I now propose to characterize the mechanisms, define the molecular players, and reveal the causes and consequences of such a high replication rate in the outcome of infection and progression of disease, by exposing the consequences for parasite genetic diversity and virulence. Connecting LS schizogony with parasite genetic diversity and virulence for the first time will be conceptually transformative, and will certainly provide valuable targets and tools for the combat against malaria.

Keywords: plasmodium replication schizogony parasite genetic diversity
Deciphering host genetics and viral determinants of MPOX epidemiology in the Democratic Republic of Congo (DECIPHER-MPOX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Uganda,Canada,United Kingdom,Congo, The Democratic Republic of the,South Africa
Call: Mobilisation of Emergency funding for Mpox outbreak research response (HORIZON-JU-GH-EDCTP3-2024-Mpox, 2024)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 1260000.0
EU funding (EUR): 1260000.0
Participants: 7
Project status: SIGNED

Background: Monkeypox virus (MPV) is a member of the Poxviridae family that includes smallpox, cowpox and chickenpox viruses. Endemic to equatorial Africa following casual human to animal or human to human transmission , recent events have seen an increased incidence with indications of sexual transmission. The disease is characterized by fever, muscle aches, skin rash, lymphadenopathy, oral sores, sore throat, cough, etc. Within any cluster of high risk contacts of a case mpox; however, not everyone exposed develops clinical disease. Moreover, among those contacts who develop mpox, not everyone gets severe disease or dies. Hypothesis: Host genetic & viral factors explain the differential outcomes following exposure to MPV. Objectives: To determine the host genetic and viral determinants of mpox disease in Kamituga area, South Kivu province, DRC. Specifically, we will (I) establish well phenotyped cohorts of house-hold contacts, (II) determine rare variants via family trios; (III) undertake RNASeq for transcriptomics, and (IV) study differential cellular immunity profiles using digital cell sorting (DCS) , (V) identify viral variants that drive severe disease Methods: Whole exome sequencing (WES), transcriptomics and DCS studies of house-family contacts clinically prequalified by PCR and serological testing. Virus gDNA will be reverse transcribed from sequenced host RNA and characterized by comparative genomics and phylogeny. Potential impact: This project will elucidate host genetic & viral determinants of susceptibility to mpox disease in context of natural exposure and infection; that may serve as correlates of immune protection following vaccination.

Keywords: mpox,host,virus,genomics,wes,transcriptomics,viral variants
Promoting Fairness of the Music Ecosystem in a Platform-Dominated and Post-Pandemic Europe (Fair MusE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Belgium,Denmark,France,Greece,Estonia,Austria,Italy,Portugal
Call: Towards a competitive, fair and sustainable European music ecosystem (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 3026734.6
EU funding (EUR): 3026587.9
Participants: 11
Project status: SIGNED

The overarching goal of Fair MusE is to promote fairness for music creators and stakeholders from an interdisciplinary perspective, thus leading to a more transparent, competitive and sustainable music ecosystem in Europe. Fair MusE focuses specifically on the domination of online platforms and their algorithms and will investigate: (i) the legal responses that have been proposed in the EU; (ii) the changes these platforms have brought to the music industry and music professionals; and (iii) the impact of such algorithms on music consumption. Fair MusE will provide an interdisciplinary analysis of fairness in the music industry involving music creators and stakeholders in the research; promote and enhance transparency concerning music industry practices and standardisation in data collection in the European music ecosystem; and assess the risks created by the reinforced dominance of the largest online platforms prompted by COVID 19 as well as making policymakers, stakeholders and the general public aware of such risks. To do so, Fair MusE will provide an innovative, strong and future-proof set of co-created responses and solutions: the 'Music Copyright Infrastructure', a data-sharing model agreement enhancing transparency; a 'Music Data Dashboard' of statistical indicators on the economic and societal value of the European music sector; the 'Fairness Score', a tool to assess music services and social media in terms of fairness’ multiple facets; and a ‘White Paper’ embodying policy recommendations to enhance competitiveness, sustainability, transparency and fairness of the EU music ecosystem. Our consortium is a carefully designed interdisciplinary group of academic and industry partners with strong expertise in the fields of law, economics, political science and computer science, supported by an Advisory Board composed of a highly qualified and broadly representative group of industry experts.

Keywords: music,fairness,transparency,music ecosystem,online platforms,algorithms,copyright
Radio stars and exoplanets: Discovering the space weather of other worlds (Epaphus)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1485971.0
EU funding (EUR): 1485971.0
Participants: 2
Project status: SIGNED

A fundamental goal of astronomy in the coming decades is to determine whether a planet around another star could be habitable. An important piece in this habitability puzzle is the environmental conditions of an exoplanet: the 'space weather' it experiences. However, determining the space weather conditions around a star has been challenging because of the limited sensitivity of low-frequency radio telescopes. A low-frequency radio detection of a star or exoplanet can provide evidence of plasma ejection from the star, or a direct measurement of an exoplanet's magnetic field strength. Such information determines if a planet's atmosphere can survive the onslaught of stellar activity. Recently, I achieved the first low-frequency detections of quiescent stars via a novel polarisation technique using the telescope LOFAR. The radio emission is likely generated by star-planet interactions -- representing a new way to discover exoplanets and characterise their space weather environment. These first detections represent the tip of the iceberg in terms of other detectable stellar systems as I expand my observations over the northern sky. I am on the precipice of conducting the first ever population analysis of the types of stars that emit at low frequencies, revealing whether they are orbited by exoplanets, and what environmental conditions such planets experience. This grant will allow me to scale my new low-frequency calibration and polarimetric techniques to determine the space weather of stars and exoplanets via: 1) determining the radio periodicity from star-exoplanet interactions; 2) directly detecting radio emission from an exoplanet; and 3) tracing the kinematics of ejected stellar plasma. Such information will facilitate a leap in our understanding of the plasma environments around stars and the underlying laws governing the generation of planetary magnetic fields -- information that will guide us in the coming revolution in exoplanet habitability.

Keywords: space weather,space physics,radio stars
Integrated AI Diagnostics in Breast Cancer (GRANITE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,France,Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 3
Project status: SIGNED

In EU-27, it is estimated that >355,000 were diagnosed with breast cancer (BC) in 2020. Initiatives to reduce this burden in Europe involve early and precise diagnosis in the standard-of-care management to decrease unnecessary or insufficient treatment. Notably, precision medicine in BC is still in its infancy and is becoming even more critical with neoadjuvant chemotherapy (NAC), a standard of care treatment protocol in HER2-positive and triple negative subtypes. Recently, the use of digital diagnostics with AI is gaining momentum since it shows great promise towards accelerating personalized BC patients’ pre- and post-NAC predictions. While AI paves the way to next generation diagnostics, this has yet from been translated as a) it mostly operates in single data modalities that fail to capture the complex disease alterations, b) integrated AI usually suffers from data incompleteness usually leading to models trained with limited data that fail to generalize to new patients and/or that are not able to integrate partially observed multimodal information from the whole population. GRANITE focuses to address these unmet needs and goes beyond the state-of-the-art, fusing the most relevant standard of care data (radiology, pathology, clinical, demographic), leveraging novel AI and radiomics algorithms. GRANITE will deploy pre-trained deep learning models that will be fine-tuned, technically validated and clinically evaluated against pertinent clinical data of non-metastatic BC cases from the Bank of Cyprus Oncology Centre, Cyprus. We will engage with the AI4HI project to transcend FUTURE-AI guidelines (Fairness, Universality, Traceability, Usability, Robustness and Explainability; future-ai.eu) into GRANITE towards generating real-world evidence and making our AI technology clinically sound, ethically aware and technically applicable, and promoting AI trust and acceptance in BC management.

Keywords: integrated ai deep learning radiomics breast cancer neoadjuvant medical imaging
Voltage-Controlled Electronic and Magnetic Phase Transitions in Nano-Devices based on Correlated Mott Materials (VOLTEMAG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: CLOSED

Matter can exhibit a complicated phase diagram comprising a large number of different electronic and magnetic states. While phase transitions induced by temperature or pressure variations, doping, and optical pulses have primarily been studied in bulk materials, phase transitions driven by a bias voltage in nano-devices are mostly unexplored. VOLTEMAG will demonstrate how different electronic and magnetic phases can be tuned through the application of a bias voltage when a material is incorporated into a two-terminal nano-device, especially in the case of materials from the strongly correlated oxides family. The researcher Dr. Anita Halder guided by Prof. S. Sanvito and Dr. A. Droghetti at Trinity College Dublin (Ireland) will develop and use a solid theoretical approach based on the Non-Equilibrium Green’s functions, Density Functional Theory and Dynamical Mean-Field Theory to predict and establish the fundamental physics of voltage-induced magnetic (ferromagnetic-antiferromagnetic) as well as electronic (metal-insulator) transitions. Devices relying on electronic phase transitions behave as multi-state transistors and resistive switches, which are currently the key hardware components to implement neuromorphic computers. The results of VOLTEMAG may therefore lead to possible technological developments, apart from their fundamental character. VOLTEMAG will then set up an extended search for new optimal materials for potential applications via machine learning algorithms. VOLTEMAG will merge the researcher’s background in materials modeling with the expertise of the host institution in quantum theory for nano-devices. The applicant will be trained on several theoretical and computational techniques essential for her future scientific career. She will be able to expand her scientific interests by being part of a large and dynamic group and she will become an independent and mature researcher.

Keywords: mott insulators,non equilibrium green s functions,density functional theory,dynamical mean field theory,material optimization machine learning