Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development (ESCALON)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Argentina,Spain,Ecuador,Colombia,Netherlands,Netherlands,United Kingdom,Canada,Chile,Peru,Brazil
Call: Translational collaborative cancer research between Europe and the Community of Latin American and Caribbean States (CELAC) (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 3503475.0
EU funding (EUR): 3283475.0
Participants: 13
Project status: SIGNED

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option. To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor. This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary tumors that could be targeted for prevention. This project will result in novel tools that are easily accessible and will dramatically reduce the burden of cancer-related mortality in Latin America.

Keywords: predictive and diagnostic biomarkers,liver cancer,hepatocellular carcinoma,cholangiocarcinoma,gallbladder carcinoma
Criminal Entanglements. A new ethnographic approach to transnational organised crime. (CRIMTANG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1999909.0
EU funding (EUR): 1999909.0
Participants: 1
Project status: SIGNED

Linked to terrorism, moral breakdown, and societal decay, Transnational Organised Crime (TOC) has come to embody current global anxieties as a figure of fear and cause of disquiet. Yet despite its central position on the social and political radar, our knowledge of it remains limited and fragmentary. Quantitative analyses may have identified the scale of the problem, but its underlying socio-cultural logic and practices remain under-researched and largely obscure. TOC is on the rise, and we need better insights into how it develops and expands, who engages in it and why, and how it is linked to and embedded in social networks that straddle countries and contexts. CRIMTANG proposes a unique approach to the study of the social infrastructure of contemporary TOC. It develops a research strategy that is ethnographic and transnational in design and so attuned to the human flows and formations of TOC. The project comprises a trans-disciplinary research team of anthropologists, criminologists and political scientists, and builds on their prior experience of the people, regions and languages under study. It explores the illegal and overlapping flows of migrants and drugs from North-West Africa into Europe, following a key trafficking trajectory stretching from Tangiers to Barcelona, Paris and beyond. In so doing, CRIMTANG sheds new light on the actual empirical processes in operation at different points along this trafficking route, whilst simultaneously developing new theoretical and methodological apparatuses for apprehending TOC that can be exported and applied in other regions and contexts. It reimagines the idea of social entanglement and proposes new transnational and collective fieldwork strategies. Finally, it will advance and consolidate the European research environment on TOC by creating a research hub for transnational ethnographic criminology at the University of Copenhagen.

Keywords: anthropology,ethnography,transnational crime,drugs,migrants,trafficking,smuggling
Identification of new regulators of Acetylcholine receptor using the nematode Caenorhabditis elegans (LEVADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-05-11
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Acetylcholine receptor is an essential component of central and peripheral nervous systems which plays a key role in numerous physiological and pathological processes. In particular, acetylcholine receptor is responsible for the coupling between nervous and muscular system at the neuromuscular junction as they are activated following acetylcholine release from neurons to triggers muscle contraction. Despite extensive work to decipher the molecular properties of the receptor itself, how the activity of the receptor and the signal following its activation are modulated is still poorly understood. This is yet an important question to address as impairment in acetylcholine receptor-associated signalling is involved in neuromuscular pathologies such as myasthenia gravis or congenital myasthenic syndrome. Here, we propose to use the genetic animal model Caenorhabditis elegans to study the dynamic regulation of acetylcholine receptors. This nematode is a powerful tool to study acetylcholine receptor as this animal also uses acetylcholine as an excitatory neurotransmitter at the neuromuscular junction. In nematode, acetylcholine receptors are sensitive to levamisole, a specific agonist. Prolonged exposure to levamisole leads to hypercontraction of the worms and finally to their paralysis. However, mutations in genes associated to acetylcholine receptor activity or biosynthesis enable the worms to adapt to levamisole. In this project, using proteomic and genetic approaches based on levamisole adaptation, we will identify several new regulators of acetylcholine receptor and of the associated signalling pathway. Deeper functional characterization will be performed on the new regulators evolutionary conserved that then may be involved in some neuromuscular pathologies. This research will give new insights into functional dynamic of acetylcholine receptor and may then shed a new light on the cause of impaired functioning of acetylcholine receptor in diseases.

Keywords: acetylcholine receptor,neuromuscular junction,c elegans,levamisole
Augmenting the Value of Conversations with Voice Transformations (ACTIVATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France,France,France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 165000.0
EU funding (EUR): 115000.0
Participants: 3
Project status: CLOSED

Project ACTIVATE aims to bring to market real-time voice-transformation technologies based on ERC CREAM's research in emotion neuroscience, which can augment the value of spoken conversations by adding business-relevant control on emotional expressivity. For instance, in the context of a call-center conversation, our real-time voice transformations may make an angry client’s voice 10% less aggressive, reducing employee fatigue at the end of the day, or make an operator’s voice 10% more trustworthy, augmenting customer satisfaction after the call. Project ACTIVATE will (1) conduct market analyses and interviews of industrial players to identify relevant conversational situations in which the technologies can be tested (e.g. for a call-center, a customer calling to resiliate their contract), (2) identify precise conversation outcomes that have market value (e.g. retention rate after the call), (3) measure the impact of the voice transformation on these outcomes in a simulated test environment that is near the desired configuration in terms of performance and user performance and (4) use the technology’s measured impact on relevant variables (e.g. a X% increase of retention rate) to estimate the value of a minimally-viable product (MVP), to be taken to market by a startup company to be created at the end of the project.

Keywords: voice,emotion,signal processing,real time,neurosciences,digital voice assistants,call center,augmentative and assistive technology
Active dielectric-on-Si3N4 double layer platform (aSINdo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-12-01
End date: 2022-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

aSINdo will study the technical feasibility and commercialization strategy of on-chip optical gain building blocks based on rare-earth ion doped Al2O3 that can be integrated onto passive integrated photonic material platforms, in particular Si3N4, to realize on-chip amplifiers and lasers. The value proposition of this technology is to enable photonic integrated circuits to achieve sufficient output power to empower multiple emerging applications. Important advantages with respect to existing solutions are the manufacturability, cost reduction, power efficiency and building block approach, which will ease the adoption of this technology by design houses and system integrators. In aSINdo we will increase the readiness level of the technology, we will define an IPR strategy and we will give the first steps towards its commercialization by means of a market study and business plan. Dissemination activities will ensure knowledge transfer to relevant parties, which may play a crucial role in defining the commercialization strategy.

Keywords: optical gain,amplifier,laser,building block,aluminium oxide,silicon nitride,photonic integrated circuit
Hybrid Enhanced Regenerative Medicine Systems (HERMES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Spain,Spain,Italy,Italy,Belgium,Finland,Netherlands,Denmark,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 8429857.5
EU funding (EUR): 8429857.5
Participants: 13
Project status: SIGNED

Brain disorders are the most invalidating condition, exceeding HIV, cancer and heart ischemia, with significant impact on society and public health. Regenerative medicine is a promising branch of health science that aims at restoring brain function by rebuilding brain tissue. However, repairing the brain is one of the hardest challenges and we are still unable to effectively rebuild brain matter. Epilepsy is particularly challenging due to its dynamic nature caused by the relentless brain damage and aberrant rearrangements of brain rewiring. To overcome the biological uncertainty of canonical regenerative approaches, we propose an innovative solution based on intelligent biohybrids, made by the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence, to effectively drive self-repair of dysfunctional brain circuits and we validate it against animal models of epilepsy. HERMES fosters the emergence of a novel biomedical paradigm, rooted in the use of biohybrid neuronics (neural electronics), which we name enhanced regenerative medicine. To this end, HERMES will promote interdisciplinary cross-fertilization within and outside the consortium; it will extend the concepts of enhanced brain regeneration to philosophy, ethics, policy and society to foster the emergence of a new innovation eco-system. Intelligent biohybrids will represent a major breakthrough to advance brain repair research beyond regenerative medicine and neurotechnology alone; it will bring new knowledge in neurobiology, cognitive neuroscience and philosophy, and new neuromorphic technology and AI algorithms. HERMES will bring a giant conceptual leap that will shift the concept of biomedical interventions from treating to healing. In turn, it will potentially generate major returns on health care and society at large by bringing previously unimaginable possibilities to defeat disorders that represent today a global major burden of disease.

Keywords: biohybrid,brain repair,epilepsy,tissue engineering,neuromorphic engineering,artificial intelligence
The influence of ocean acidification on phytotransferrin-mediated iron uptake rates in phytoplankton (IRONBIND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2020-05-31
Duration (months): 12.0
Total project cost (EUR): 87403.2
EU funding (EUR): 87403.2
Participants: 1
Project status: CLOSED

The ability of phytoplankton to access the micronutrient iron fuels vast marine ecosystems, drives biogeochemical cycles and influences climate on a planetary scale. Recent studies in the model diatom Phaeodactylum tricornutum have revealed that high-affinity iron uptake uses a carbonate-dependent phytotransferrin which is highly sensitive to ocean acidification. This project seeks to validate and extend the hypothesis that ocean acidification negatively affects the growth of marine phytoplankton by interfering with this carbonate sensitive uptake mechanism. The influence of acidification on iron uptake rates will be characterized in a number of environmentally relevant and phylogenetically diverse strains of phytoplankton, and results will be confirmed using a combination of reverse genetics and environmental validation. The resulting chemical, biological and rate-constant data will be integrated into large-scale biogeochemical Ocean General Circulation Models, which will allow us to place these results into ecological context. This project will transfer cutting-edge molecular techniques and genomic analyses to the host institution while training the experienced researcher in key analytical and biogeochemical modeling methods. Capacity-building courses in project management and opportunities for communication are planned to further develop the future potential of the researcher. Because of the outsized role that iron-limited phytoplankton have in biogeochemical cycles and the sequestration of carbon dioxide, the multidisciplinary outputs of this action are expected to be of high impact and broad interest to a wide array of disciplines, including biogeochemists, climate modelers, policy makers and resource managers.

Keywords: ocean acidification,phytoplankton,iron uptake,diatom,biogeochemistry
Worker-Centric Workplaces in Smart Factories (FACTS4WORKERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Austria,Italy,Austria,Germany,Germany,Spain,Switzerland,Finland,Slovenia,Slovenia,Belgium,Slovenia
Call: Developing smart factories that are attractive to workers (H2020-FoF-2014, 2014)
Start date: 2014-12-01
End date: 2018-11-30
Duration (months): 48.0
Total project cost (EUR): 7916441.25
EU funding (EUR): 6344544.38
Participants: 17
Project status: CLOSED

It is the high ambition of the project to create “FACTorieS for WORKERS” (FACTS4WORKERS), therefore a serious effort will be put into integrating already available IT enablers into a seamless & flexible Smart Factory infrastructure based on worker-centric and data-driven technology building blocks. As FACTS4WORKERS is underpinned by a clear human-centric approach: usability, user experience and technology acceptance are of the utmost project interest. FACTS4WORKERS will develop and demonstrate workplace solutions that support the inclusion of increasing elements of knowledge work on the factory floor. These solutions will empower workers on the shop floor with smart factory ICT infrastructure. Advancement will be gained through integrating several building blocks from a flexible smart factory infrastructure, focusing on workers’ needs, expectations and requirements, and being supported by organisational measures and change management. In line with our assumptions on impacts on productivity we therefore estimate that that we can increase job satisfaction for 800,000 European workers by the year 2025. These solutions will be developed according to the following four industrial challenges which are generalise-able to manufacturing in general: personalised augmented operator (IC1), worked-centric rich-media knowledge sharing/management (IC2), self-learning manufacturing workplaces (IC3) and in-situ mobile learning in the production (IC4). Moreover, FACT4WORKER‘s objectives in terms of measureable indicators are: • To increase problem-solving and innovation skills of workers; • To increase cognitive job satisfaction of workers; • To increase average worker productivity by 10%; • To achieve TRL 5-7 on a number of worker-centric solutions through which workers become the smart element in smart factories The smart factory demonstrator will be run within the automotive supply chain. The consortium is composed by 15 partners from 7 different EU member states.

Keywords: smart factory,industry 4 0,augmented reality,learning,big data,semantic technologies,empowered worker,work satisfaction
Storage-Enabled Sustainable Energy for Buildings and Communities (SENSIBLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Germany,Finland,France,United Kingdom,Portugal,Portugal
Call: Local / small-scale storage (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 15381148.79
EU funding (EUR): 11842396.76
Participants: 16
Project status: CLOSED

The project SENSIBLE addresses the call LCE-08-2014 by integrating electro-chemical, electro-mechanical and thermal storage technologies as well micro-generation (CHP, heat pumps) and renewable energy sources (PV) into power and energy networks as well as homes and buildings. The benefits of storage integration will be demonstrated with three demonstrators in Portugal, UK and Germany. Évora (Portugal) will demonstrate storage-enabled power flow, power quality control and grid resilience/robustness in (predominantly low-voltage) power distribution networks – under the assumption that these networks are „weak“ and potentially unreliable. Nottingham (UK) will focus on storage-enabled energy management and energy market participation of buildings (homes) and communities – under the assumption that the grid is „strong“ (so, with no or little restrictions from the grid). Nuremberg (Germany) will focus on multi-modal energy storage in larger buildings, considering thermal storage, CHP, and different energy vectors (electricity, gas). An important aspect of the project is about how to connect the local storage capacity with the energy markets in a way that results in sustainable business models for small scale storage deployment, especially in buildings and communities. SENSIBLE will also conduct life cycle analyses and assess the socio-economic impact of small-scale storage integrated in buildings distribution networks. By integrating different storage technologies into local energy grids as well as homes and buildings, and by connecting these storage facilities to the energy markets, the project SENSIBLE will have a significant impact on local energy flows in energy grids as well as on the energy utilization in buildings and communities. The impacts range from increased self-sufficiency, power quality and network stability all the way to sustainable business models for local energy generation and storage.

Keywords: storage integration,power network operation,energy management,building automation and control systems,energy markets