Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An automated platform for the large-scale production of miniaturized neuromuscular organoids (MiniOrgans)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Organoids have been developed as advanced 3D cell culture systems that resemble aspects of the in vivo tissues and provide an alternative to study the mechanisms of human disease and identify novel treatments. The last years have witnessed tremendous developments in the field of stem cell and organoid research, but the full potential of these systems remains to be exploited. Two major challenges facing the organoid field are reproducibility and scalability. The manual production of organoids is a labor-intensive and expensive process. The development of cost-effective, fast, and reliable methods is a prerequisite for transferring organoid technologies to the industry for high-throughput approaches. We have recently established a novel complex human neuromuscular organoid (NMO) model from human pluripotent stem cell-derived neuromesodermal progenitors. NMOs self-organize into spinal cord neurons and skeletal muscle compartments that contract by forming functional neuromuscular junctions. The ERC consolidator grant “GPSorganoids” focuses on the generation of position-specific (GPS) NMOs representing distinct spinal cord segments and the use of such NMOs models to study the selective vulnerability of specific spinal cord neurons to neuromuscular diseases like amyotrophic lateral sclerosis and spinal muscular atrophy. The PoC grant goes beyond the scope of our ERC consolidator grant and focuses on the commercialization of the NMO model through the establishment of an automated, reliable, and high throughput production line that could apply to industry settings. Our ultimate goal is to establish NMOs as a leading model in the market for high throughput drug screening approaches and accelerate the development of novel therapies for neuromuscular disorders.
Reslocate – AI Career Intelligence for the Future of Education (RESLOCATE OU)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 12.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

Reslocate is an AI-driven career-intelligence platform designed to bridge the gap between education and employability across Africa and Europe through trustworthy, explainable AI. The project’s objective is to transform fragmented, manual career-guidance systems into a predictive, data-driven infrastructure that helps learners choose suitable studies, parents make informed decisions, schools monitor performance, and governments align education outputs with labour-market needs. To achieve these goals, Reslocate will advance its current TRL 6 prototype to TRL 8 by developing a multilingual, GDPR-compliant neuro-symbolic AI that integrates academic, behavioural, and labour-market data. The system will deliver real-time APS calculations, personalised course and scholarship recommendations, parental dashboards, and policy analytics. Building on validated pilots with 2 700 learners in South Africa, the project will expand from one to fifteen markets across SADC and the EU by 2026, reaching over one million learners and 150 000 paying parents. EIC blended finance will fund R&D, ethical-AI certification, multilingual model training, and market deployment. The proposal directly supports the Horizon Europe work programme by contributing to inclusive, transparent, and human-centred digital transformation in education. It advances the EU Digital Education Action Plan (2021–2027), the EU AI Act, and the Africa–EU Global Gateway Partnership by promoting ethical AI, youth employability, and data-driven policymaking. Through EIC support, Reslocate will create measurable social, economic, and gender-equitable impact, establishing Europe-led Career Intelligence Infrastructure as a global benchmark for trustworthy educational AI.

Keywords: ai career intelligence
Novel High-Luminosity Photonics for AntiMatter-OTech Opaque Neutrino Detection (SHINE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 1268157.5
EU funding (EUR): 1268157.5
Participants: 2
Project status: SIGNED

The AntiMatter-OTech project (EIC grant) aims to demonstrate the potential performance of a completely new strategy for non-intrusive nuclear reactor monitoring, exploiting the intrinsic reactor’s fission antineutrino emanation. This enables a new insight into nuclear facilities with even possible integration into existing installations. Since their discovery using reactors in the 50s, antineutrino detection capabilities have been limited by their signal-to-background ratio despite significant improvement. A groundbreaking potential opens with LiquidO’s unique ability to tag the antimatter nature of the antineutrino upon detection. In brief, any strategy capable of boosting the detected light output will directly impact the ultimate performance of its subatomic topological imaging as well as the so far available calorimetry information. After long optimisation with prototypes, the only possible improvements ahead are the optical fibres’ light collection and today’s scintillators’ light yield per energy deposited. Despite decades of effort, the fundamental light losses remain uncontrolled, historically limiting detection in the MeV range worldwide. The SHINE proposal aims to address this challenge by the definition of a new photonics detection framework to be integrated into the AntiMatter-OTech LiquidO-based detector for a possible technological breakthrough by improving both optical fibres, in tight cooperation with Kuraray (Japan) and a new wave of scintillation technology. This is expected to boost all the original goals with no project re-scoping whatsoever. The project relies on the latest advances in photo-chemistry technology never employed in neutrino detection that may revolutionise the worldwide MeV detection and instrumentation well beyond the AntiMatter-OTech scope, including major opportunities for European industry. SHINE leads to the strengthening of the original consortium by recognised renowned expertise by specialised photo-chemical scientists.

Keywords: antimatter otech,neutrino,detector,liquido,light yield,photonics,technology,scintillation,optical fibre
Networked Distributed Neural Interfaces for Interference-Based Brain Stimulation (BRAINET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Ireland,United Kingdom,Finland,Portugal,Austria,Denmark,France,Greece,Netherlands
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4360039.2
EU funding (EUR): 4360039.2
Participants: 17
Project status: SIGNED

Invasive Deep Brain Stimulation (DBS) has become an important way to treat neurological diseases within the greying European society making a tether-less improvement desireable. The BRAINET team is convinced to have identified such an alternative in spatio-temporal Interference Stimulation (stIS). stIS avoids implantation into the brain and uses instead pairs of electrodes to precisely target activating beating rhythms in the depth of the brain at the therapeutic region, without requiring deep seated electrodes. In order to unleash this stimulation power in all regions of the brain, BRAINET sets out to develop skull implantable stimulation hubs which build a communication network and 3D targeting by self-organization, providing semantic information transfer and synchronization, and thus enabling virtual, self-adjusting pairs for therapeutic stIS. These stimulation hubs will be powered by novel magneto-electrical transducer stacks, driven by slowly alternating magnetic fields from the outside and will perform adjustable frequency stimulation by novel nano-modified, compliant electrodes only touching the brain. Network formation will be enabled by multiphysics approaches and ionic in-body communication instantiated in dedicated microelectronic hardware. Preclinical in-vitro and in-vivo testing of devices and methods will allow the community to make important steps towards subsequent clinical implementation of our „Wireless Transcalvarial Brain Stimulators“. BRAINET will allow us to prepare the next generation of researchers, arming them with the knowledge, skills, and visionary insights necessary to drive neuro-technology to replace the present DBS into uncharted, but reliably safer and more flexible territories. BRAINET is an engine for excellence, interdisciplinary convergence, and innovation. Its dual mandate is to establish a training network and thus to lay the groundwork for emerging leaders.

Keywords: temporal interference stimulation,bioelectronic medicine,deep brain stimulation
Strategic Infrastructure for improved animal Tracking in European Seas (STRAITS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Ireland,Denmark,Belgium,Türkiye,Canada,Portugal,Spain,Norway
Call: Research infrastructure concept development (HORIZON-INFRA-2022-DEV-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3285945.0
EU funding (EUR): 3285944.5
Participants: 10
Project status: SIGNED

In order to protect and manage marine species and habitats, there is an immediate need for the creation of robust evidence-based methods and integrated platforms. Therefore, there is a need to undertake marine research projects that are developed and implemented collaboratively, strategically, and at a sufficient scale. Animal tracking is the study of animal movements across various spatiotemporal scales (local, regional, continental, global; minutes to decades). Although animal tracking is not a new field of research, only recently have these electronic technologies necessary to follow marine animal movements across larger and longer scales have only recently become widely available. Strategic Infrastructure for improved animal Tracking in European Seas (STRAITS) will leverage ongoing acoustic tracking projects across the four corners of Europe (i.e., North Channel, Danish Straits, Straits of Gibraltar and the Bosporus/Dardanelles) by expanding efforts to connect initiatives on species-based biodiversity management while developing data management plans and networking channels to deliver data to national and international governing bodies. Coordinating aquatic animal tracking and environmental observation efforts at a scale that will be usable to make progress on international marine management and planning, is a major step towards an operational European Tracking Network (ETN) that contributes to major European biodiversity initiatives, conservation, and policy.

Keywords: analytics,marine,biodiversity,infrastructure,telemetry,fish movements,connectivity,marine fauna migrations,integrated data management,multi species
Quantisation of moduli spaces: Hitchin connections and isomonodromic deformations (QuantMod)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United States,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2026-10-01
Duration (months): 36.0
Total project cost (EUR): 276681.6
EU funding (EUR): 276681.6
Participants: 2
Project status: SIGNED

Our goal is to construct generalisations of the Hitchin and Wess--Zumino--Witten (WZW) and Knizhnik--Zamolodchikov (KZ) connections, both in geometric and deformation quantisation, and of their associated monodromy representations. The Hitchin connection achieved the quantisation of compact Chern--Simons theory and resulted in the construction of a topological quantum field theory. A different projectively flat connection provides a viable mathematical definition of correlation functions in the WZW model for conformal field theory. The resulting projectively flat vector bundles are isomorphic, and their monodromies have far-reaching applications in low-dimensional topology/geometry (quantum invariants of knots/3-manifolds) and representation theory (of mapping class/quantum/braid groups). Our guiding viewpoint is that the connections of Hitchin/WZW can be derived from the quantisation of moduli spaces of connections on Riemann surfaces. We will extend this further, focusing on meromorphic connections with high-order poles (i.e., wild singularities), generalising the above bundles and their applications. The motivation for this project is twofold. First, there is now a complete understanding of the Poisson/symplectic nature of isomonodromic deformations of wild singularitites, which are naturally amenable to quantisation. The quantum theory is much less developed than the classical one, and this naturally motivates us to close the gap using the latter as a guide. Second, recent work related the genus-zero WZW connection---that is, the KZ connection---to a new version of the Hitchin connection, and this was then used for the quantisation of moduli spaces of parabolic bundles. We want to pursue extensions of this identification; in particular, we will use the new flat connections constructed on the deformation quantisation side as candidates for `wild' Hitchin connections, in the geometric quantisation of wild character varieties: a complete novelty.

Keywords: geometric quantisation,deformation quantisation,flat connections,mapping class groups,isomonodromic deformations
A novel, intelligent turbine control solution to increase the efficiency of hydropower plants (IVAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1600000.0
EU funding (EUR): 1600000.0
Participants: 1
Project status: SIGNED

Over 16% of the world’s energy is produced by hydropower. However, hydropower has an aging fleet, with nearly half of its global capacity being more than 30 years old. As hydro turbines age, they also experience a drop-off in efficiency. Upgrading a single turbine is currently a highly costly (typically >€3.0 million) and complex process. Weis has identified a unique way to rapidly upgrade the performance and efficiency of existing hydro turbines at a relatively low cost. Existing hydro turbines employ a single actuator to control the guide vanes that direct flow to the turbine impeller. The rudimentary control of these vanes gives rise to turbulent flow, reducing the efficiency of the turbine by up to 10%. Weis has devised and developed IVAC, a cloud-connected Intelligent Vane Actuation System to deliver higher efficiency in hydro turbines. IVAC is a retrofittable intelligent guide vane control system that enables precise manipulation of each individual vane according to flow and turbulence conditions using advanced sensor technology and data fusion control algorithms. IVAC reduces vane load, neutralises turbulence, and increases efficiency by up to 10%. Weis has invested close to €500k in developing its technology to TRL6, successfully completing testing and validation of the IVAC technology in a 1:5 scale Francis turbine (FT) at the Norwegian University of Science and Technology. Success has drawn the attention of Europe’s largest hydro operators, and contractual agreements for pilot trials on a small scale (2.7MW) operational turbine have been signed with Hafslund Eco. EIC Accelerator funding will allow Weis to scale up design and demonstrate the IVAC system in a real-world large-scale turbine, thereby overcoming the last major barrier to entry in what is considered a conservative industry. With EIC funding, we aim to launch IVAC by the end of 2027 and realize annual revenues of €23.1 million and net profits of €6.6 million in 2030.

Keywords: hydropower,hydroelectricity,francis turbine,control systems,autonomous control,fluid dynamics,energy efficiency,data fusion,data algorithms
Revolutionary Land-Based Algae Cultivation and Bioremediation System for Sustainable Aquaculture (MEDALG)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

At Mediterranean Algae, we are tackling the escalating environmental degradation and climate change challenges by revolutionizing the aquaculture industry. Our innovative, land-based algae cultivation system directly addresses the critical issues of nutrient pollution and unsustainable practices in fish farming. By integrating advanced technologies such as photobioreactors and automated environmental control systems, our solution enables precise control over algae growth, resulting in consistent, high-quality production year-round. This method not only reduces the carbon footprint of aquaculture but also transforms waste into valuable biomass, enriching our algae with proteins, amino acids, and vitamins, making it highly marketable in the food, cosmetics, and pharmaceutical sectors. Our system’s key benefits are threefold: it significantly enhances water quality by absorbing excess nutrients from fish farm waste, which improves fish health and yields; it supports the European Union’s Green Deal objectives by creating a circular economy and reducing greenhouse gas emissions; and it offers a cost-effective solution for fish farms, turning a waste management challenge into a profitable venture. We are confident that Mediterranean Algae’s technology is set to play a pivotal role in the sustainable transformation of the aquaculture industry, aligning with global and European sustainability goals.

Keywords: environmental degradation,aquaculture industry,land based algae cultivation,nutrient pollution,fish farming,photobioreactors,marine ecosystems and processes,low zero carbon communities
The scale-up of the BioMilk platform: The revolutionary approach to manufacturing of biopharmaceuticals (BioMilk-mAb)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-10-01
End date: 2026-12-31
Duration (months): 27.0
Total project cost (EUR): 3536986.67
EU funding (EUR): 2475890.67
Participants: 1
Project status: SIGNED

Bio-Sourcing has developed a BioMilk platform, a new paradigm-shifting technology to produce biosimilar molecules in the milk of genetically engineered goats. This breakthrough development producing genetically modified goats using CRISPR-Cas9 produces 100% pure progeny of goats with genes of interest of biosimilar. Our bioproduction method is up to 5x more cost-efficient reducing costs from €100-200 of to €25 per gram of API and has 10x less CAPEX reducing investment costs from €200-300 million to 35 million and 1000x lower Co2 footprint reducing it from 25T to 5 per Kg of API, compared to conventional methods, allowing its scalability and industrialization with significantly less carbon footprint. The BioMilk platform has the potential to be market creating and disrupt the biotherapeutics manufacturing and biosimilar markets with an enormous market opportunity of €100B. The main goal of the project is to successfully complete the non-clinical analytical studies for three biosimilars with the highest market potential and perform the phase-I clinical validation of the first biosimilar. This will help Bio-Sourcing to close a licensing deal for the sales of the biosimilars to a pharma or biogeneric-producing company by 2027. Bio-Sourcing will remain the exclusive producer and act as a supplier of API to its customers who will sell fully formulated biosimilars. Bio-Sourcing is expected to receive upfront payments and milestones (€40M in total per biosimilar) and generate longer-term revenue through sales of API and royalty payment on net sales (5%). Bio-Sourcing seeks EICA blended finance (€2.5M grant and €10M equity), which will enable Bio-Sourcing to reach its value inflection point of successfully completing the important Phase I study for the first biosimilar from the BioMilk platform for human health application.

Keywords: biotherapeutics,monoclonal antibodies,drug manufacturing
Pioneering platform technology to develop innovative treatments for high unmet medical needs (MT-discover)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 1
Project status: SIGNED

By 2050, the elderly population will nearly double and age-related diseases will surge. From a medical perspective, stiffening of the skeleton of our cells is considered a universal driver of age-related diseases. While this is widely accepted by the pharmaceutical industry that seeks to correct these defects to improve patients’ lives, current treatments that target the skeleton of our cells directly elicit severe adverse side effects. We developed the “MT-discover”, a unique modular discovery platform to extract an untapped pharmaceutical space and generate lead compounds to target specific enzymes, and reverse abnormal stiffness of our cytoskeleton, without adverse effects. The modular scalable platform delivered the first lead compound (MT-X01) to become a transformative treatment in hypertrophic cardiomyopathy. MT-X01 has been proven safe, and in the gold standard preclinical disease model, we demonstrated the efficacy of its Mechanism of Action. The market value of MT-X01 is forecast at €2.95bn by 2031.

Keywords: microtubules,cytoskeleton,hypertrophic cardiomyopathy,tubulin,vash inhibition,companion tests,platform,modular technology,discovery engine