Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel roles of dimethylated sulphur in marine microbial interactions (SUMMIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2499187.0
EU funding (EUR): 2499187.0
Participants: 1
Project status: SIGNED

Sulphur is an essential element for life that cycles rapidly in the pelagic ocean in the form of biogenic dimethylated compounds. Over three decades, dimethylated sulphur has been intensively investigated for its emission to the atmosphere and its suggested roles in returning sulphur to continents and in climate regulation. While the climate connection still awaits definitive confirmation or denial, these research efforts have provided important advances in plankton physiology and ecology, since these forms of sulphur arise from organism adaptation to saline and sunlit waters and are integral to the food web machinery. Previous studies have disclosed biochemical and trophic cycling pathways and their taxonomic affiliations. Also, evidence for their behaviour as infochemicals in organism-organism communication has been obtained. However, their contribution to the functioning of marine ecosystems remains largely unexplored, particularly with respect to the emerging renewed picture of food webs, where classical functional roles blur and concepts like multifunctional organisms and interdependence become the rule rather than the exception. I propose to bridge microbial physiology, ecology and biogeochemistry to explore new roles of dimethylated sulphur in microbial food-web interactions. I will build upon a combination of molecular tools, isotopes, single-cell analyses, physiological dyes, chemotaxis experiments, modelling, sea-going opportunities and an existing collection of samples from diverse oceanic biomes. Hypothesis-driven research is expected to yield paradigm shifts in (i) phytoplankton-bacteria interactions through nitrogen fixation and vitamin exchange; (ii) phytoplankton-phytoplankton interactions to overcome energy limitation to growth; (iii) phytoplankton-herbivore interactions for selective grazing on weakened prey. Overall, I intend to assess if interactions through dimethylated sulphur make microbial food-webs more robust and efficient.

Keywords: dimethylated organic sulphur,plankton,picoalgae,bacteria,microzooplankton,nitrogen fixation,dmsp,vitamin b12,methionine,chemotaxis,mutualism,food web
Cost-efficient and safe cellulosic food pad (CellSorb)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Synthetic superabsorbent polymers (SAPs) are the mainstream option (i.e. 90% of market share) to be used as absorbent pads in a number of applications, from sanitary products (e.g. diapers, tampons) to food pads (e.g. meat/fish trays to soak up exuded liquids and keep the food fresh). This is mainly due to their superior price-efficiency balance. Nevertheless, proven toxicity and carcinogenic effects related with their use have raised growing health concerns. To put these dangerous practices aside the need of economical biodegradable and non-toxic pads to compete with the synthetic ones are on the rise. Cellsorb introduces a totally safe (i.e. non-toxic) closed food pad made from bioplastics and superabsorbent micro-cellulose material with the following superior features: 1) Absorbs multiple times its own weight similar with the performance of synthetic food pads, 2) It is fully compostable and 100% renewable, and 3) Competitive pricing over synthetic made food pads. Its uniqueness lies on our innovative production method able to produce microcellulose materials from pulp, creating a non-toxic and biodegradable superabsorbent able to compete in cost-effectiveness with current synthetic ones.

Keywords: food pad,packaging,superabsorbent
The Social Anthropology of Rabies Epidemiology and Elimination (SAREE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-15
End date: 2021-11-29
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 2
Project status: CLOSED

Rabies is a viral disease transmitted to humans through the bite of rabid animals, predominantly domestic dogs. It is ranked among the highest priority zoonotic neglected diseases by major international human and animal health organizations (the World Health Organization and World Organisation for Animal Health) and its control is considered a global public good. Although rabies is preventable through administration of post-exposure prohylaxis to individuals exposed to suspect rabid bites and mass vaccination of dogs, the disease still kills thousands globally. India has the highest number of rabies deaths in the world for reasons that are likely to be as much socio-cultural as they are biological, although these factors have neither been investigated nor integrated with epidemiological data. In India, I will focus on two contrasting (based on linguistic, cultural and religious background) rural areas of Gujarat and Maharashtra, where rabies is very prevalent. I will first investigate cultural and religious aspects shaping attitudes towards dogs and local-level acceptance of rabies control and prevention measures, including dog vaccination and human rabies prevention. I will subsequently explore the feasibility and acceptability of in-depth epidemiological data collection tools, contact tracing, to understand cultural and religious influences on people’s health seeking behaviour, practices that may lead to increased rabies risks, and management of these risks within this particular socio-cultural context. Data gathered in this preparatory phase will ultimately inform the design of culturally acceptable and integrated One Health interventions that will to contribute to reduced rabies exposures and mortality. Together with these expected health benefits, my project will demonstrate the added value of One Health, interdisciplinary, approaches to the study and management of zoonoses, and will therefore address an evidence gap of global health relevance.

Keywords: social and medical anthropology,field epidemiology,infectious disease,neglected zoonosis,canine rabies,rural india,risk,cultural and religious determinants of health,one health
Cross-linking Adenosine Receptors - Estrogen receptors for OA treatment (C.A.R.E. OA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-25
End date: 2023-02-24
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

The purpose of this project is to define how estrogen- and adenosine-receptors modulate each other in CD4+ T-cells during osteoarthritis (OA) development and how these pathways can be targeted for development of a new OA therapy. Alterations of the articular cartilage function and of the joint surrounding tissues lead to disease like OA. OA is a chronic invalidating disease with a large social impact. There is no cure and the treatments to manage symptoms, pharmacological and non-pharmacological therapies, are useful only for a limited time, after which joint replacement surgery is necessary. Women have increased risk of developing OA compared to men and epidemiology studies suggest that hormonal alterations play an important role in OA development. It is now widely recognized that inflammation is an important disease mechanism in OA pathogenesis. In particular CD4+ T cells have been identified as triggers of cartilage degradation in OA. CD4+ T cells express estrogen- and adenosine receptors, two important regulators of the immune system. In a recently published article, I showed that female mice lacking one of the adenosine receptors, A2A (A2AR), develop spontaneous OA with significantly milder disease symptoms compared to males suggesting a protective effect of female sex hormones on OA development. Interestingly, it has been shown that estrogens can modulate the expression of adenosine receptors. In this project, I am going to investigate the effect of pharmacological activation of estrogen receptors on the anti-inflammatory A2AR and the pro-inflammatory A2BR, and the involvement of their mutual interaction on CD4+ T cell proliferation, differentiation and migration ability. Moreover, the effect of combined A2B adenosine receptor blocking and estrogen treatment will be tested as a strategy for reducing pain and disease progression in an OA mouse model.

Keywords: osteoarthritis,adenosine,estrogens,cd4 lymphocytes
Autonomous Robotics for Transcatheter dEliveRy sYstems (ARTERY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Belgium,Switzerland,Belgium
Call: Research and Innovation boosting promising robotics applications (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-03-31
Duration (months): 39.0
Total project cost (EUR): 3044437.5
EU funding (EUR): 3044437.5
Participants: 8
Project status: SIGNED

Cardiovascular diseases are the single most common cause of death in Europe and worldwide. Minimally invasive catheter-based approaches gain in importance as they extend treatment to patients with high peri-operative risks. Today, catheter-based treatment comes with steep learning curves, poor ergonomics and exposure to damaging radiation. The ARTERY project offers a radiation-free approach based on shared-autonomy robotic catheters, with increased user engagement and easy interaction. Echocardiography, optical and electromagnetic sensing techniques provide a superior view upon the cardiovascular space. Fluidic actuation paired with artificial intelligence form the motors of the next generation of robotic catheters that autonomously find their way towards the target site. The interventionist is fully immersed in the surgical field. Key landmarks automatically highlighted in the holographic display give the impression of being teleported right inside the patient’s anatomy. Variable-autonomy schemes allow the interventionist to take over control at any instant. Artificial intelligence algorithms turn catheter navigation to a simple task as the autonomous catheters maneuver their distal portion to align to where the interventionist points his/her finger. ARTERY showcases this new paradigm on mitral valve repair and left appendage closure, two complex yet critical life-saving interventions. Clinicians and company partners are ready to take over the technology developed in ARTERY and translate it to the clinic right after the project.

Keywords: artificial intelligence,shared autonomy
Origin and evolution of intracellular symbioses in plants (ORIGINS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1996027.0
EU funding (EUR): 1996027.0
Participants: 1
Project status: SIGNED

Mutualism between plants and microorganisms has been essential for the evolution of terrestrial ecosystems for millions of years. It has been proposed that even the colonization of lands by plants was facilitated by a mutualistic symbiosis formed with arbuscular mycorrhizal fungi. This symbiosis, by far the most widespread in land plants, results in the accommodation of the symbiotic fungus inside the plant cells. Following this initial symbiosis, multiple other intracellular symbioses have evolved in plants as diverse as orchids, Ericaceae such as cranberry, legumes or the Jungermanniales, a group of bryophytes. These symbioses provide numerous benefits, improving plant nutrient acquisition and fitness. Despite their absolute importance in terrestrial ecosystems, the molecular mechanisms underlying the origin and subsequent evolution of intracellular symbioses in plants remain poorly understood. In a first objective, we will use CRISPR/Cas9 in the bryophyte Marchantia paleacea to test the conservation across land plants of symbiotic mechanisms known in angiosperms. Then, we will decipher how these mechanisms evolved by comparing land plants with their closest algal relatives. In a second objective, we will conduct transcriptomics coupled with genetic manipulations of most known intracellular symbioses in plants. This will allow determining how the ability to host intracellularly microbial symbionts recruited in the environment evolved repeatedly in land plants and how functional specificity evolved in these different symbioses. Lastly, we will investigate why the evolution of intracellular symbioses is constrained to a unique genetic pathway. Through this project, combining phylogenomics, biochemistry, transcriptomics and genetic validations in six plant lineages covering more than 500 million years of evolution, we will provide a comprehensive understanding of the molecular mechanisms underlying the evolution of intracellular mutualistic symbioses in plants.

Keywords: plant symbioses,evo devo,marchantia,arbuscular mycorrhizal symbiosis,gene regulatory networks,zygnematophyceae
TERRITORIAL CIRCULAR SYSTEMIC SOLUTION FOR THE UPCYCLING OF RESIDUES FROM THE AGRIFOOD SECTOR (Agro2Circular)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Austria,Spain,Spain,Italy,Italy,Italy,Germany,Spain,Spain,Spain,Belgium,Lithuania,Finland,Switzerland,Greece,France,Netherlands,United Kingdom
Call: Demonstration of systemic solutions for the territorial deployment of the circular economy (H2020-LC-GD-2020-3, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 16757026.91
EU funding (EUR): 14074828.28
Participants: 42
Project status: SIGNED

Agro2Circular (A2C) project is focused on the implementation of the first territorial systemic solution for the upcycling of most relevant residues in the agrifood sector (fruits& vegetables and plastic multilayers) into high added value products, powered by a digital tool and constructed upon a systemic approach with high replicable/scalable potential. Through this solution, A2C will face important industrial, economic & social challenges in the agrifood sector: 1) The fruits & vegetables (F&V) are the group of major contribution to food waste along the food supply chain rising up to > 40% of waste, and are as excellent source of natural bioactives. However, these F&V wastes are not exploited. A2C will valorise them by green routes to obtain these bioactives for the production of nutraceuticals, functional foods, and cosmetics. 3) Multilayer plastic films are widely used as industrial packaging for the protection of food and agriculture for crops due to their unique barrier properties. However, there is a lack of sorting and recycling technologies for an economic and environmentally sustainable valorisation of these multilayer structures. A2C will develop the first recycling value chain for post-industrial multilayer films based on a synergistic approach combining innovative sorting, physical delamination, enzymatic depolymerisation, decontamination & mechanical recycling. 3) There is a lack of digitalisation in the agrifood sector. A2C will implement a Data Integration System (DIS) as a digital tool for ensuring traceability and as Predictive Decision Tool in the agrifood sector. A2C will be a demonstrated in the Regi?n de Murcia (Spain) and replicable systemic solution throughout Europe for the territorial deployment of the circular economy.

Keywords: multilayer plastics,territorial systemic solution,upcicling,recicling,digitalisation,agrifood
Bidirectional flow filter: microfluidic device for separation of biomolecules (BiFlowFilter)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-03-01
End date: 2021-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The analysis of extremely small samples is boosting the field of life and medical science, from basic research on single-cell systems, through point-of-care diagnostics, to forensic analysis. Despite great advances made on analytical techniques such as digital immunoassay, nanopore detection and next-generation sequencing, little progress has been made on low-volume sample preparation technologies, which are key for the success of such analytical techniques. To date, despite the availability of a large arsenal of sample preparation methods, current approaches are simply not suitable for volumes below the microliter range. In this proposed ERC proof-of-concept project we aim to develop a device and method for rapid and high-purity extraction of molecules and particles from sub-microliter volumes. The main objectives of this project cover the technical optimization and validation of the technology as well as the establishment of a solid foundation for its commercialization. We believe that this separation technology will be uniquely positioned in the sample preparation market and has the potential to be an important component in the future of point-of-care diagnostics and personalized medicine.

Keywords: microfluidics,biomolecular separation,sample preparation,electrokinetics,proteins,electroosmotic flow
GlioDx - Blood platelet-based monitoring and treatment optimisation for glioblastoma patients (GlioDx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Glioblastoma (GBM) is a devastating primary brain cancer which affects about 230.000 people annually. The choice for treatment depends on the subtype of GBM. An accurate detection of tumour subtype is therefore essential for a personalised targeted treatment. Diagnosis, classification and treatment monitoring occurs currently by radiology and repeated invasive biopsies. There is a need for non-invasive, actionable biomarkers for early-stage diagnosis and disease monitoring. During our ERC research, we discovered that mRNA sequenced from tumour-educated platelets enables for pan-cancer, multiclass cancer and companion diagnostics. We were able to distinguish between primary and metastasised tumours in the brain and also establish the molecular subtype of the tumour. These findings provide strong support for using tumour-educated platelets as a biomarker for early stratification, diagnosis and prognosis for personalised GBM treatment. As a proof-of-concept of our innovative diagnostic tests, we will validate the proprietary algorithms underlying these tests specifically in GBM patients. To achieve this, we focus on the differentiation of glioblastoma subtype based on the platelet mRNA profile. In addition we will validate treatment monitoring and response prediction to an EGFR targeted drug in GBM patients. GlioDx will also assess the feasibility to commercialise the technology. The team has developed several business and IP models which need to be assessed thoroughly through in-depth market research and business planning activities. The results need to be consolidated into a strong business plan that will be presented to investors and strategic investors.

Keywords: glioblastoma,cancer,blood platelets,egfr,treatment,diagnostic