Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Equitable RESilience solutions to strengthen the link between CUltural landscapEs and coMmunitiEs (RescueME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Austria,Greece,Croatia,Belgium
Call: Effects of climate change and natural hazards on cultural heritage and remediation (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2026-07-31
Duration (months): 42.0
Total project cost (EUR): 3998994.0
EU funding (EUR): 3998994.0
Participants: 17
Project status: SIGNED

Our common heritage is a central element of our communities and economies, and a principal but vulnerable dimension of our common identity as Europeans. It has been proven that cultural heritage contributes to well-being, social cohesion, identity, local economy, territorial attractiveness, and environmental sustainability, but the climate crisis and natural hazards endanger this heritage. We propose RescueME to take immediate action for demonstrating how an innovative data-driven, community-based, heritage-centric actionable landscape approach to resilience enhancement can protect our cultural heritage and landscapes while supporting the transition toward a green society and economy that sustains resilient, cohesive, nature-connected communities. RescueME proposes a call for action, broadening the scope, triggering action, untapping and mobilizing resources, engaging actors, and facilitating the decision making and the implantation of co-created just resilience solutions to protect our common heritage. RescueME will develop, test and demonstrate the effectiveness of an Actionable Framework based on the Resilient Historical Landscape approach (RHL) complemented by data, models, methods, and tools able to assess risks and opportunities, co-develop inclusive and just resilience strategies and innovative solutions to protect European cultural heritage and cultural landscapes from climate change, disaster risk, as well as other stressors (such as pollution and over-tourism) with special focus on European coastal landscapes since a large share of this endangered heritage there. The five case studies (Psiloritis in Creta, Neuwerk in Hamburg, Portovenere, Cinque Terre & the Islands, València and the city of Zadar) have been selected carefully as complementary representatives of European coastal landscapes. They will act as resilience landscape laboratories (R- labscapes), validate the results and ensure their replicability.

Keywords: cultural landscapes,heritage,resilience pathways,climate change,hazards,data driven tools,local community,adaptive strategies,co creation,data platform,ai,crowdsourcing
Pioneering RNA therapies for inherited retinal diseases: novel ocular antisense oligonucleotides for Stargardt Disease (STGD1) and USH2A-associated retinal disease. (ASTH-IRD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Astherna develops vision-saving therapies for Stargardt Disease 1 (STGD1), caused by mutations in the ABCA4 gene, and USH2A-associated retinal disease (USH2A & RP39), using antisense oligonucleotides (ASO). Our lead compounds ASTH-A768 and ASTH-U53, specifically targeting defined regions within the pre-mRNA of the genes involved, tackle the root cause problem in these diseases. During the EICA project, we focus on the toxicological assessment of ASTH-A768 during the grant period, since this is the most developed molecule with the biggest market potential in our portfolio. The equity phase will contain the ASTH-A768 Phase 1/2a clinical study and the development of ASTH-U53 to proof-of-concept (in-vitro, in-vivo, tox and Phase 1/2a). This will make our compounds ready for late-stage Phase 3 clinical trials and prepared for (a) licensing deal(s) in 2029. Astherna will generate revenues from up-front payments, milestone payments and royalties. Revenues will be used to accelerate the expansion of our portfolio to other Stargardt- and USH2A-associated retinal disease-causing mutations, as well as to other inherited retinal diseases.

Keywords: ush2a associated retinal disease,usher syndrome,stargardt disease 1,rna therapies,inherited retinal diseases,antisense oligonucleotides
Breakthrough Integration and Resolution in Defect Repair (BIRD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3570125.0
EU funding (EUR): 2499087.5
Participants: 1
Project status: SIGNED

The BIRD European project (Bringing Intelligent Resolution to Defect-repair) aims to revolutionize the repair of defects in high-precision industries, such as display manufacturing and semiconductors. It will develop and integrate a groundbreaking additive manufacturing technology that enables nanometric-scale defect resolution, addressing critical issues like luminance inconsistencies and pixel misalignments. This solution, called High Precision Capillary Printing (HPCaP), perfectly addresses the challenges encountered due to miniaturization and complexity at nanoscales, and even goes far beyond expectations. Not only does the process provide unparalleled high resolution (between 100 nm and 50 microns), but it also enables the deposition of any liquid material on any surface with a high degree of design freedom. The company's flagship product, the NAZCA prototyping tool, has reached TRL 8 and has been sold to leading clients in Europe, the U.S., and Asia. The next step involves scaling this innovation to create a commercial-grade repair module designed for seamless integration into display and semiconductor industries production lines. This HPCaP module will address a serviceable obtainable market (SOM) estimated at over €91M by 2028. By partnering with top European research institutions and industry players, BIRD will ensure the validation and scalability of this innovative technology, targeting high-yield, defect-free production. As the display and semiconductor industries face increasing demand for precision manufacturing, Hummink’s solutions provide a timely response to growing concerns over waste and yield losses. This project supports the objectives of the European Green Deal by promoting sustainable, resource-efficient manufacturing, reducing waste, and contributing to Europe’s technological sovereignty. Through this, BIRD will significantly enhance the competitiveness of European industries in high-volume manufacturing and semiconductor repair markets.

Keywords: high precision capillary printing,defect repair,lcd oled display,nanoelectronics,production yield rate,ink
Scalable Photonic pAckaging for high-peRformance optiCal interconnects (SPARC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The exponential growth of AI, cloud computing, and quantum technologies is driving a revolution in digital infrastructure, with optical connectivity emerging as the backbone for high-capacity, energy-efficient data transfer. However, the physical interface between optical fibers and photonic chips remains a critical bottleneck, limiting scalability, serviceability, and cost-effectiveness in next-generation systems such as data centers, telecom networks, and quantum computers. Current fiber-to-chip interconnect solutions are bulky, fragile, expensive, and not designed for mass production or modularity, threatening to stall the optical revolution at the interface where light meets silicon. ICON Photonics addresses this urgent challenge by pioneering the world's most compact, high-precision, and detachable Co-Packaged-Optics fiber-to-chip connector. Inspired by the simplicity and versatility of USB-C, ICON’s technology enables passive, self-aligned assembly and true modularity—unlocking scalable, serviceable, and cost-efficient optical infrastructure. The solution is compatible with wafer-level manufacturing, enabling integration densities exceeding 1,000 fibres per switch and delivering significant reductions in assembly steps and costs. This solution enables the mass deployment of advanced photonic systems for AI, quantum computing, and high-performance computing while reducing energy consumption and environmental impact. This breakthrough positions ICON Photonics as a foundational enabler of the optical era, setting new standards for manufacturability, performance, and sustainability in digital infrastructure.

Keywords: photonic packaging,fiber to chip interconnect,optical connectivity,detachable optical connector,high density fiber array,wafer level integration
Safe 3D Object Detection For Robotics (Safe3D)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2380000.0
EU funding (EUR): 2380000.0
Participants: 1
Project status: SIGNED

Autonomous mobile robots (AMRs) could supercharge productivity and efficiency, whilst addressing labour shortages and supporting an ageing society, leading to their annual uptake increasing by >30%. Yet currently, safe human-robot interaction is the leading concern for end users, policy makers, standardization bodies and robot manufacturers. Safety requires AMRs to reliably detect obstacles in all directions of movement along their route and navigate indoors. This is currently enabled through a suboptimal suite of sensors, which are: 1) very expensive (~30% of the robot cost), 2) limited in field of view, and, 3) large and bulky, increasing robot design complexity. AMRs are thus mostly separated from people or limited in their movements, creating a critical deployment bottleneck. In response, Sonair has shrunk the ultrasonic parking sensor to a mm-sized transducer creating a 3D distance sensor that provides autonomous robots with omnidirectional depth sensing. This is based on 20 years of breakthrough research on applying piezo-electrical materials in Micro ElectroMechanical Systems (MEMS), resulting in several patents and a novel sensing technique called Acoustic Detection and Ranging. It works by emitting a burst of ultrasound and analysing the signals received by a phased array. This method gives a 3D view of the area in front of the robot, allowing it to detect distance and direction of all objects in a 180x180 degree field of view and a 5m range, in real-time. Sonair’s sensor will disrupt the AMR market as it is 50-80% cheaper, compact and easy-to-integrate into robots. Ultimately, it will make robots safer, accelerating their deployment in industry, healthcare, services, automotive and agriculture. The EIC Accelerator project will enable Sonair to fast-track commercialization of the world’s first 3D safety certified ultrasonic sensor for the €4.13B robotic sensors market to achieve an annual revenue of >€70M, whilst growing our team by 43 people, by 2031.

Keywords: micro electromechanical system,mems,piezo electrical materials,ultrasound,transducer,vision systems,automated mobile robots,3d sensing in air,lidar,miniaturization,semiconductors
Novel AI tool to reduce the Economic cost and carbon footprint of industrial & construction waste (Akanthas)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

A large amount of industrial waste is generated globally which is rich in useful materials and valuable resources but is wasted due to poor management and high sorting time. The quantity of waste generated is overwhelming which can make it difficult to collect, transport, and treat effectively. The type of waste generated (solids and other hazardous substances) also makes it crucial to follow the European waste regulations, along with specific regulations of each member country. Efforts have been made to develop technologies that can sort and manage waste effectively but are not applicable in real industrial applications. Most of the solutions cater to municipal waste which just consists of 12% of the total waste generated making the entire exercise expensive and manually exhausting. Keeping this need in mind, Akanthas has developed a complete waste sorting and management platform that can easily sort large quantities of industrial waste accurately, giving a complete profile of the waste bins in real time. The solution consists of our propriety imaging camera and AI-incorporated software system that takes images of the waste bin (large skips and waste containers) and generates accurate waste profiles in the form of a dashboard. Our solution will speed up waste sorting, reduce errors, and streamline waste management logistics for our consumers. With reduced sorting errors, we will effectively improve the carbon footprint and enhance regulatory compliance, therefore reducing the risk of fines and penalties. Under the EIC project, we plan to improve the sensing capabilities of our hardware , develop a more robust database of waste types, perform customer validation, and successfully launch our system throughout the EU.

Keywords: environmental and green technologies,waste recycling,big data machine learning,statistical data processing and applications using signal processing e g speech,image,video
Metastable Epiallele: Role of Epigenetic Variability for the Development of Metabolic and Endocrine Diseases (E-VarEndo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1997969.0
EU funding (EUR): 1997969.0
Participants: 1
Project status: SIGNED

The development of obesity in industrial and low-and middle-income countries is leading to a severe burden for patients and health care systems based on associated comorbidities as cardiovascular diseases and type 2 diabetes mellitus. Apart from the genetic background, epigenetic modifications like DNA methylation are supposed to play an important role for body weight regulation. So far, epigenome-wide association studies were not able to elucidate this relationship, as most methylation differences were related to a genetic variant. Therefore, the identification of the POMC (pro-opiomelanocortin) gene, a key factor for hypothalamic body weight regulation, as a metastable epiallele in humans, was of importance to understand how methylation variability affect the individual phenotype. Metastable epialleles are methylome-regions, which are non-genetically determined, stochastically regulated and set in early embryonic development. Furthermore, they are non-tissue specific, stable over time and modified by Carbon-1 metabolites in-utero. However, their role for human diseases remained unclear. Within this application, I want to elucidate and characterize how epigenetic modifications as metastable epialleles modulate human susceptibility and predisposition to metabolic and endocrine diseases and analyse the impact of environmental factors. To achieve this goal, I propose a unique approach using advanced technologies to analyse human postmortem samples and human embryonic stem cells to identify new metastable epialleles in humans and elucidate new mechanisms and relationships between phenotypic variation and methylation variability. The combination of the algorithm to identify methylation variability and the use of stem cell models to functionally characterize epigenetic variants will be a blueprint for the analysis of the epigenetic contribution for other endocrine, neurological or cardiovascular diseases and will generate a powerful resource for researchers worldwide.

Keywords: metastable epialleles,obesity,dna methylation variability
Paving the way for High-throughput Organoid ENgineering using Integrated acoustiX (PHOENIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2832500.0
EU funding (EUR): 2832500.0
Participants: 1
Project status: SIGNED

The aim of PHOENIX is to use my expertise in microsystems engineering to close critical technology gaps in organoid generation. Cerebral organoids are 3D self-assembled structures derived from human induced pluripotent stem cells, replicating both structure and function of the human foetal brain. Organoids have the potential to replace existing 2D cell cultures and animal models, but this has not yet been realised due to rudimentary preparation methods. In PHOENIX, three important technology gaps will be addressed: reproducibility, controlled maturation and vascularisation. I aim to build on my pioneering research on droplet acoustofluidics and the scientific output of my ERC Starting Grant to develop three microfluidic modules that at the end of the project shall be integrated into a seamless organoid engineering pipeline. The technology in focus is acoustophoresis, a method to manipulate particles and cells by ultrasound. This will be used to achieve ordered encapsulation of stem cells in hydrogel droplets and develop a microfluidic platform where the cells can be differentiated under fully controlled conditions. Finally, two-photon writing will be used to integrate a vascular network with the organoid constructs to form an important delivery architecture for nutrients and blood components. PHOENIX will be focused on both technology development and thorough biological characterisation of the resulting organoids to demonstrate both expected, and unexpected, benefits of transferring organoid generation on-chip. Collaborations have been established with Prof. Christine Mummery and Dr. Valeria Orlova, both at LUMC, NL as well as Dr. Anna Falk at KI, SE to provide expertise in complementary fields of this highly interdisciplinary project. The expected output of PHOENIX is a microfluidic technology that enables high-throughput generation of cerebral organoid with a multi-regional structure and vascularisation in a direct process.

Keywords: microfluidics,droplet microfluidics,acoustophoresis,organs on chip,organoids
Community Through Constitution. REsearching how CONstitutions Construct Identity and LEgitimacy in Europe and MENA (RECONCILE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Czechia
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999784.0
EU funding (EUR): 1999784.0
Participants: 1
Project status: SIGNED

Constitutionalism provides a shared-meaning space, in which the idea of rights has served to emancipate individuals. This rights-based constitutionalism is in decline. It has ossified, became isolated from politics, and alienated from people in the West and faced difficulties to take roots in other cultural backgrounds. The problem is that the rights-based constitutionalism is unable to foster collective identity due to its conceptual limitations. Populist movements (secular and religious alike) thrive on this failure and forge a collective identity around simplified and homogenized cultural characteristics, which trumps individual rights and leads to exclusion and social injustice. The solution is to develop the integrative function of the constitution. So far, all attempts, primarily constitutional patriotism, failed. It requires nothing less than a new theory of constitutionalism (call it identity constitutionalism), which connects the philosophical tradition of intersubjectivity, discursive theories of constitutionalism, and social-cognitive perspective on identity construction. I claim that such constitution-based collective identity is possible if constitution becomes central to political discourse. It happens under three conditions: (1) if constitution is perceived as authentic (constitutional authenticity), (2) creates a shared-meaning space for communication by incorporating major sources of local and global morality (normative compatibility) and (3) motivates actors to prefer constitutional speech over nationalist and religious ones through an adversarial institutional setting (institutional adversariality). To prove the hypothesis, I will research constitutions’ discursive centrality and the sense of community among citizens in four European (secular and Christian) and four Middle Eastern and North African (Islamic) countries through a hybrid methodology combining supervised computational analysis of political discourses and quantitative survey research.

Keywords: constitutionalism identity european union middle east and north africa comparative constitutional law islam christianity human rights international law