Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Intimate, home-diagnostic tools for women (iTampon)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Hungary
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

At Dr. Dolhay, our mission is to provide female hygiene and health products that serve the health of women and their sexual partners by use in the intimacy of the home. The iTampon project involves an innovative method – completely free of electronics – to diagnose female health at home. These two novel diagnostic devices will enable women to detect the sign of any infection, indicating the need to turn to a gynaecologist. Additional examinations can be carried out by sending samples to our laboratory partner. Early warning of potential diseases, such as cervical cancer or preterm birth, can save millions of lives, as women could undergo the necessary treatment in time. The project originates from a business development idea to internationally expand our current, market-leading product lines. However, the development has convinced two EU-based companies to offer us EU-wide cooperation, once the products are qualified to be launched on the market. The need for the products is well demonstrated, as it breaks through the key barrier women have against going to the gynaecologist: shyness and anxiety. We have developed two prototypes that are essential diagnostic tools at the level of consumer goods – keeping the intimacy of women using them: 1) Intelligent Tampon Observer (iT Observer): it is a “pH meter” (“good flora indicator”) which provides a pH-status map of the whole vagina and cervix. 2) Intelligent Tampon Collector (iT Collector): it is a 2in1 solution, a “pH meter” and “home HPV/cancer test” which enables women to perform a basic gynecological self-examination in the privacy of their home.

Keywords: self diagnostic tools,women s health,ph testing,hpv testing,testing at home,pap smear,cervical cancer,vaginal infections
Data Intensive Modelling of the Rhizosphere Processes (DIMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-08-31
Duration (months): 84.0
Total project cost (EUR): 1996246.0
EU funding (EUR): 1996246.0
Participants: 1
Project status: CLOSED

We rely on soil to support the crops on which we depend. Less obviously we also rely on soil for a host of 'free services' from which we benefit. For example, soil buffers the hydrological system greatly reducing the risk of flooding after heavy rain; soil contains very large quantities of carbon, which would otherwise be released into the atmosphere where it would contribute to climate change. Given its importance it is not surprising that soil, especially its interaction with plant roots, has been a focus of many researchers. However the complex and opaque nature of soil has always made it a difficult medium to study. In this ERC research program I will develop a state of the art image based model of the physical and chemical properties of soil and soil-root interactions, i.e., a quantitative, model of the rhizosphere based on fundamental scientific laws. This will be realised by a combination of innovative, data rich fusion of structural and chemical imaging methods, integration of experimental efforts to both support and challenge modelling capabilities at the scale of underpinning bio-physical processes, and application of mathematically sound homogenisation/scale-up techniques to translate knowledge from rhizosphere to field scale. The specific science questions I will address with these techniques are: (1) how does the soil around the root, the rhizosphere, function and influence the soil ecosystems at multiple scales, (2) what is the role of root-soil interface micro morphology and mycorrhizae on plant nutrient uptake, (3) what is the effect of plant exuded mucilage on the soil morphology, mechanics and resulting field and ecosystem scale soil function and (4) how to translate this knowledge from the single root scale to root system, field and ecosystem scale in order to predict how the climate change, different soil management strategies and plant breeding will influence the soil fertility.

Keywords: soil science,rhizosphere science and modelling,plant soil interaction
Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development (DyNAmecs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1495480.0
EU funding (EUR): 1495480.0
Participants: 1
Project status: SIGNED

Immediately after fertilization, mammalian genomes undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment. This is best exemplified by DNA methylation reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation. Moreover, once DNA methylation patterns are established, mechanisms faithfully maintain the mark across cell division. Thus, there is latent potential for DNA methylation deposited in the early embryo to exhibit a lifelong effect. DNA methylation is a modification that is typically associated with gene repression at repetitive elements and at a minority of protein coding genes. I previously described the regulation of the Zdbf2 gene in mice, which is programmed during the de novo DNA methylation program. Challenging the paradigm, in this case DNA methylation is required for activation of a gene via antagonism of the polycomb-group of silencing proteins. If the DNA methylation fails to occur, the gene stays silent throughout life, resulting in a reduced growth phenotype. For my proposed research I will utilize both a cell-based system that recapitulates these early embryonic events as well as an in vivo mouse model to investigate the extent and mechanisms of non-canonical DNA methylation functions. I plan to use a combinatorial approach of genomics, genetics, and proteomics in order to ascertain novel insights into DNA methylation-based regulation. Furthermore, I plan to employ precision epigenome editing tools to address the locus-specific impact of DNA methylation. Ultimately, I strive to gain a clear understanding of the profound epigenetic consequences of DNA methylation on this window of development, which occurs in the first week of mouse embryogenesis, and the second of human, but the repercussions of which can ripple throughout life.

Keywords: dna methylation,polycomb,epigenetics,mammalian development,embryonic stem cells
Interoperable Material-to-Device simulation box for disruptive electronics (INTERSECT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Spain,Germany,Italy,Italy,Switzerland,Belgium
Call: Accelerating the uptake of materials modelling software (IA) (H2020-NMBP-TO-IND-2018, 2018)
Start date: 2019-01-01
End date: 2022-04-30
Duration (months): 40.0
Total project cost (EUR): 3904468.0
EU funding (EUR): 3591965.5
Participants: 9
Project status: CLOSED

Information-and-communication technologies have been historically powered by silicon, with development and production taking place mostly, albeit not exclusively, in the United States and in Asia. The current and major worldwide drive for big data, machine learning, and quantum computing will push away from this all-silicon platform, and provide a unique opportunity and a clean slate for European industry to rapidly deploy novel technologies based on innovative materials and devices. Leadership will require fast exploration of materials’ properties (e.g. memory effects for memristive computing), linking properties to performance in unexplored architectures, and assessing their business potential. INTERSECT wants to leverage European leadership in materials’ modelling software and infrastructure, as embodied in track record of the team, to provide industry-ready integrated solutions that are fully compliant with a vision of semantic interoperability driven by standardized ontologies. The resulting IM2D framework - an interoperable material-to-device simulation platform - will integrate some of the most used open-source materials modelling codes (Quantum ESPRESSO and SIESTA) with models and modelling software for emerging devices (GinestraTM) via the SimPhony infrastructure for semantic interoperability and ontologies, powered by the AiiDA workflow engine, and its data-on-demand capabilities and apps interface. API-compliance with established standards will allow pipelines to and from public repositories, and embedding into the front-end of materials hubs, such as MarketPlace, while testing, validation, and standardization will take place together with the industrial partners. INTERSECT will drive the uptake of materials modelling software in industry, bridging the gap between academic innovation and industrial novel production, with a goal of accelerating by one order of magnitude the process of materials’ selection and device design and deployment.

Keywords: synaptic electronics,interoperability,software uptaking,industrail driven material modelling
Direct Statistical Simulation of the Sun and Stars (D5S)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2499899.0
EU funding (EUR): 2499899.0
Participants: 1
Project status: SIGNED

This proposal (D5S) addresses a key problem of astrophysics – the origin of magnetic activity in the sun and solar-type stars. This is a problem not only of outstanding theoretical importance but also significant practical impact – solar activity has major terrestrial consequences. An increase in activity can lead to an increase in the number and violence of solar flares and coronal mass ejections, with profound consequences for our terrestrial environment, causing disruption to satellites and power. Predictions of magnetic activity are highly desired by government and industry groups alike. A deep understanding of the mechanisms leading to solar magnetic activity is required. The variable magnetic field is generated by a dynamo in the solar interior. Though this mechanism is known to involve the interaction of magnetohydrodynamic (MHD) turbulence with rotation, no realistic model for dynamo action currently exists. D5S utilises two recent significant breakthroughs to construct new models for magnetic field generation in the sun and other solar-type stars. The first of these involves an entirely new approach termed Direct Statistical Simulation (DSS) (developed by the PI), where the statistics of the astrophysical flows are solved directly (enabling the construction of more realistic models). This approach is coupled to a breakthrough (recently published by the PI in Nature) in our understanding of the physics of MHD turbulence at the extreme parameters relevant to solar interiors. D5S also uses the methodology of DSS to provide statistical subgrid models for Direct Numerical Simulation (DNS). This will increase the utility, fidelity and predictability of such models for solar magnetic activity. Either of these new approaches, taken in isolation, would lead to significant progress in our understanding of magnetic field generation in stars. Taken together, as in this proposal, they will provide a paradigm shift in our theories for solar magnetic activity.

Keywords: magnetic fields,dynamo action,solar cycle,stars,astrophysical turbulence,direct statistical simulation numerical astrophysics,planetary atmospheres,general circulation model
Federated CPS Digital Innovation Hubs for the Smart Anything Everywhere Initiative (FED4SAE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Austria,Ireland,Italy,Germany,Hungary,Sweden,Switzerland,France,France,France,United Kingdom
Call: Smart Anything Everywhere Initiative (H2020-ICT-2016-2, 2016)
Start date: 2017-09-01
End date: 2021-01-31
Duration (months): 41.0
Total project cost (EUR): 7629658.26
EU funding (EUR): 6995195.77
Participants: 16
Project status: CLOSED

The overall ambition of the FED4SAE innovation action (IA) is to boost and sustain the digitization of the European industry by strengthening competitiveness in Cyber Physical Systems (CPS) and embedded system markets. In alignment with the "Smart Anything Everywhere" initiative goals, FED4SAE will: - Create a pan-European network of Digital Innovation Hubs (DIH) by leveraging existing regional ecosystems across full value chains and a range of competencies. DIHs will enable both tech and non-tech innovative Third parties (Startups SMEs, Midcaps) from any sector to build new products and services with “digital inside”. - Act as a European added-value one-stop-shop to facilitate innovators-suppliers cross-border partnerships which will accelerate innovation in products and processes of European Third parties by providing technical, industrial and innovation management expertise. This will lead to quantifiable increases in market shares, productivity, industrial capacities of the Third parties, and a broader adoption of CPS and embedded systems solutions. - Link innovators to investors associated to DIHs to reach out to further funding opportunities and enable the next steps of the Third parties’ developments after completing their application experiments (AEs). - Ensure the self-sustainability of the DIHs pan-European network by developing cooperation with regional organizations and key stakeholders engaging public and or private investment to fund FED4SAE network activities. FED4SAE is built upon the key learnings obtained in the EuroCPS, Gateone-project, CPSE Labs IAs. FED4SAE will leverage the best practices related to Third party engagement, submission, evaluation and selection of AEs. FED4SAE will give birth to a competitive ecosystem where European Startups, SMEs and Midcaps will thrive as they access to leading technology sources, competencies and industrial platforms and also to well-connected business infrastructures and existing regional innovation hubs.

Keywords: digital innovation hubs,application experiments,cascade funding,innovation management,community engagement,coaching,industrial technology platforms
World’s first unmanned, fully aseptic multi-functional commercial filling line for the bio-/pharmaceutical industry (Aseptic Smart)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Italy,Italy,Switzerland,Switzerland,Serbia,Hungary
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 3694625.0
EU funding (EUR): 2586237.5
Participants: 6
Project status: CLOSED

Aseptic Smart will demonstrate a novel fully robotised, multifunctional pharmaceutical filling line with capabilities of processing several container types (vials, syringes, cartridges, ampoules, etc.) and thus bringing the sector to the fore of Industry 4.0 revolution, which is the future of manufacturing in Europe. The technology enables fast changeovers ( 30 minutes) thus providing manufacturing flexibility and agility critical in processing smaller batches of more personalised injectable medicines. Robots eliminate the need for human intervention in aseptic area and thus solve two traditional challenges within the pharma industry-sterility assurance and contamination risk reduction. Machines have a modular design which allows cheaper and faster scaling out through addition of more modules where production increase is required and reduces technology transfer costs by 94%. The technology has the following additional advantages#58;58% lower operational costs - ca. 87% less parts reduce maintenance costs and energy consumption;Compact – up to 50% smaller size as robots replace bulky material movement components e.g. conveyor belts delivering manufacturing space savings;Increased process repeatability – robots reduce rejection rates to virtually zero (less than 0.05%)Because of this, the technology has attracted interest of some large pharma companies who, like several others, are shifting from developing quot;blockbusterquot; drugs towards personalised medicine; driving growth of the €6.6 billion global pharma packaging equipment market. The project will refine robot gripping system, integrate machines to robots, develop machine vision and control system before validation and end user demonstration in actual environment. This will support fast commercialisation enabling the consortium to capture 1.5% of the market 5 years after commercialisation, translating to cumulative consortium revenue of over earn cumulative revenues of €97m and return on investment of 696%.

Keywords: industry 4 0,robotized manufacturing,pharma manufacturing,injkectable drugs,isolator,aseptic process
Boosting Reward-based Attention through VEstibular STimulation (BRAVEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Intrinsically rewarding stimuli strongly favour attentional capture (AC) in humans, this effect being dramatic in a number of addiction disorders. The physiology of this phenomenon is poorly understood, but recent neuroimaging studies point to a role of the Anterior Cingulate Cortex (aCC) in this kind of attentional engagement. A way to act on this circuitry would provide compelling evidence and be a major advance for the cognitive and clinical neuroscience of motivation. Most brain stimulation techniques (i.e. TMS, tDCS) typically do not allow for stimulation of deep brain structures, their effect being limited to superficial areas. In contrast, Vestibular Stimulation (VS), via galvanic or thermal activation of the peripheral organs devoted to balance, have been consistently shown to produce reliable activation of deep structures involved in mood and affective processing, including the aCC. VS are routinely employed in medicine and physiology, but a deeper understanding of their cognitive effects is needed. Here I propose having healthy participants and patients with brain damage and attentional disorders (i.e. Spatial Neglect) to complete simple behavioural tasks assessing the interaction between attention and motivation, while receiving VS. The main objective is to assess whether the modulation of brain activity through VS may modulate the degree of AC, i.e. facilitate the orienting of attention towards rewarding stimuli. Such project could not only greatly advance our knowledge on the neural circuitry underlying the interplay between reward processing and visuospatial attention, but also shed light on the neural underpinnings of the aberrant AC observed in several clinical pathologies, allowing devising novel therapeutic approaches. Beside this main goal, I will receive advanced training for fMRI analysis, boosting my attractiveness as independent scholar and allowing me to further explore the role of brain areas extending beyond the aCC.

Keywords: priority maps,attentional capture,reward,brain stimulation,vestibular stimulation,anterior cingulate cortex,unilateral spatial neglect,addictive disorders,fmri
Sound it out: inferring foraging ecology from a predator-embarked acoustic recorder (SOUNDBITES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-14
End date: 2020-05-13
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Like many seabirds, penguins face the challenge of provisioning young on shore from a constantly changing food resource at sea requiring efficient localization and exploitation of ephemeral prey aggregations. For penguins, this critical activity is taking place against a backdrop of global warming which is rapidly changing the physical and biological environment in the Southern Ocean. Given the difficulties and expense in following animals at sea, bio-logging devices have been a key tool for studying penguins and have yielded important data on individual movement and foraging tactics. However, for an animal that is so notably social in its dense colonies, remarkably little is known about social interactions at sea or within the colony, and whether these aid or thwart foraging. Through SOUNDBITES, I will collect the first acoustic and multi-sensor data from penguins during foraging trips providing a revolutionary new view of how penguins locate and exploit resources. SOUNDBITES will (I) develop and test on captive seabirds a novel, advanced multi-sensor acoustic tag, the seabirdDTAG, that will enable studies of their interactions, foraging ecology and energetics, (II) deploy the tag on Adélie penguins reproducing in the Antarctic, to examine the role of intraspecific communication in resource acquisition through studies of foraging decisions during consecutive foraging trips in breeding partners. In accomplishing SOUNDBITES’ objectives, I will open a powerful new way to study vocal interactions in seabirds and enable detailed reconstruction of foraging decisions and success in the context of vocal interchange with conspecifics. These unique data, directly relevant to European Commission’s Biodiversity Strategy, will help assess the resilience of these central place foragers to changing environment/resources and, by aiding the interpretation of movement data already collected from penguins, increase the value of an important decade-scale monitoring effort.

Keywords: foraging ecology,bioacoustics,bio logging,seabirds,movement ecology,marine predators,foraging decisions