Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coordinating and synchronising multimodal transport improving road, rail, water and air transport through increased automation and user involvement (ORCHESTRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Switzerland,Switzerland,Norway,Norway,Norway,Norway,France,Netherlands
Call: Network and traffic management for future mobility (H2020-MG-2020-TwoStages, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 5167361.88
EU funding (EUR): 4998798.75
Participants: 17
Project status: SIGNED

The long-term vision of the ORCHESTRA is a future where it is easy to coordinate and synchronise the traffic management of all modes to cope with diverse demands and situations. Also, to facilitate optimal utilisation of transport networks and efficient multimodal transport services, both in rural and urban areas. The project will: * Establish a common understanding of multimodal traffic management concepts and solutions, within and across different modes, for various stakeholders and multiple contexts * Define a Multimodal Traffic Management Ecosystem (MTME) where traffic managements in different modes and areas (rural and urban) are coordinated to contribute to a more balanced and resilient transport system, bridging current barriers and silos * Support MTME realisation and deployments, through the provision of tools, models, and guidelines - including support for connected and automated vehicles and vessels (CAVs) * Validate and adjust MTME for organisational issues, functionality, capability, and usability * Maximise outreach and uptake of project results through strong stakeholder involvement The project will provide a Polycentric Multimodal Architecture (PMA) that specify how diverse system components collaborate and interact, taking into account smart infrastructures, technical and organisational aspects and polycentric governance. The PMA will be supported by: 1) Enabling toolkit, 2) Deployment toolkit, 3) Documented lessons learned. The project will validate the PMA and related tools and toolkits in two Living labs (in Norway and Italy), collectively covering both road, rail, water, and air transport. The Italian Living lab is focusing on traffic orchestration for the mobility of people, while the Norwegian Living lab is focusing on traffic orchestration for freight. The Living labs will be supported by simulations to enhance evaluations.

Keywords: resilience engineering,transport networks,automated transport
Feasibility study for clinical validation of an innovative point of care assay for the detection of low-grade-infections in joint replacement (QuantOnCal)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

About 10-15% of the primary hip and knee arthroplasties have to be revised after surgery. A special case of loosening of implants is the low-grade-infection, which is mostly not recognized and not treated adequately and leads to further revision surgeries and immense impact for the patient. Established markers all failed in the past, in contrast elevated calprotectin and S100A12 levels show a high correlation to low-grade-infections. Immundiagnostik AG developed its own robust smartphone-application based point-of-care assay for measuring calprotectin quantitatively and rapidly without any laboratory. Extending this concept to a calprotectin and S100A12 duplex text low-grade-infections in joint replacement can be detected within minutes for the first time ever. This method will replace time consuming laboratory testing and will help the surgeon to decide in the operation theatre if a two-stage-revision is indicated. Thus health and quality of life for patients is improved and costs for and rate of revision surgery could be reduced significantly. The market size for the new assay and app will be over 60 million Euro in a year. Users of the new diagnosis by will be clinicians in endoprosthesis centres. The innovation will be a quantitative two parameter rapid assay and a smartphone-app as a reader. Two-stage-revision surgery of endoprosthesis as a result of low-grade-infection is a European and worldwide burden. The problem can only be solved in an European consortium to ensure access to European opinion leaders in arthroplasties and to European markets and therefore broad dissemination and exploitation of the project results. Within the feasibility study (phase 1) the following work is intended: Establishing the smart low grade infection assay, patent application, market survey, setup of a multicentre clinical study, preparation of a business plan. Within the project (phase 2), the assay and app will be validated in a large European clinical study.

Keywords: joint replacement,endoprosthesis,low grade infection,revision surgery,calprotectin,s100a12
Road and rail tunnel fire protection (Tunnelsafe2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fire in tunnels is a worldwide problem that leads to disasters with infrastructural challenges and huge economic and human losses as a result. In spite of all efforts to control and prevent human errors, and to detect technical problems, accidents will occur, and without efficient fire extinguishing capability, some of these accidents will develop into catastrophes. The amount of smoke and the extreme temperatures developed in tunnel fires prohibits fire fighters and rescue workers to reach the burning objects to save the trapped people. Damage to the structure with subsequent closure of the tunnel often leads to challenges for infrastructure and societal costs. Fireproofing of tunnels has been discussed for years, but a method that effectively extinguishes any fire, reduces smoke to secure safe evacuation and reduce the damage on the structure, has to this date not been applied. Fire Eater is a specialist in a fire extinguishing solution that can extinguish fire anywhere inside an enclosure. It has proven safe and efficient in applications as airports, Off-Shore, power generation and distribution, datacentres, warehouses with mixed goods and chemicals, cable tunnels and much more. Fire Eater has developed the basic engineering solution to apply our method to tunnels. Only recently it has been possible to locate a full size tunnel available to do the required testing and demonstration. The highly innovative element in the application is the transfer of a proven technology to an entirely new area of use: rail and road tunnels. When proven successful in full scale it will not only represent an interesting business opportunity, but also enable the creation of new standards for tunnel fire safety. The purpose of the project is a detailed feasibility study, to plan and engineer the test programme, to define acceptance criteria with the customer, and to search for consortium partners needed to supply the complete system package needed in this market.

Keywords: protection,fire,safety,tunnel,rail,road
Dual Function Polymer Materials for Blood Contacting Applications (DualFun)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-18
End date: 2019-09-17
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Device-related thrombosis is associated with activation of blood clotting and platelets adhesion and activation. Infection of the implanted devices occurred as a result of bacteria adhesion to the biomaterial surface. A genuinely biocompatible polymer for blood-contacting devices should have both antithrombotic and antibacterial functionalities as both types of complication lead to an increase in morbidity, extended hospital stay and mortality. In order to prevent device-induced thrombosis and infection novel dual function polymer materials - thromboresistant and antimicrobial, will be produced. A novel and original approach that involves construction of multifunctional coatings, which combine formulation of the NO-generating surface with the ability to prevent bacterial adhesion, capacity to inhibit platelet adhesion and the use of surface bound argatroban drug to inhibit any surface-produced thrombin, will be applied. The polymer matrices chosen for the design of dual function materials are the most commonly used synthetic polymers polyurethane (PU) and polyvinylchloride (PVC) and the biopolymer collagen. This aim will be achieved by: i) chemical attachment of the organoselenium or copper nanoparticle catalysts to the polymer surface in order to continuously generate NO by decomposition of endogenous S-nitrosothiols; ii) immobilisation of the direct thrombin inhibitor argatroban to inhibit any thrombin in the surrounding environment. Catecholamines, polydopamine and poly(norepinephrine) will be used as the surface modification reagents, as they form very stable thin films strongly attached to the polymer surface. Owing to the chemical bonding of the ligand to the polymer surface it is expected that these materials will have long storage life and exploitation period and therefore retain their ability to generate NO from the inexhaustible endogenous NO donors.

Keywords: no releasing polymers,selenium and copper compound immobilisation,thrombin inhibitor immobilisation
Cegasa Portable Hybrid Energy Storage Solution (CHESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CHESS (Cegasa Hybrid Energy Storage Solution) is a new electrochemical energy storage system to save and provide energy to agents around the electrical grid system relating to solve the instability of power generation and periodical peak-through fluctuation on the electrical grid. These kinds of necessities are more remarkable when the renewable energy sources penetration in the grid is very high intensive but also in weak grids or small grids (islands, isolated microgrids). Energy storage systems are identified as systems that can store between 200 KWh and 2 MWh of electricity but using modular products this range can be easily expanded between 10 KWh and 10 MWh. The new CHESS from CPE is a modular storage system combining two different electrochemistries, lithium-ion and zinc-rechargeable, in order to guarantee high peak power and sufficient energy flow at the optimum cost. This new system is also open for other applications such as road transport (trucks, BUS, industrial electrical vehicle, etc.) The most interesting characteristic of CHESS is the capability to adjust to customers’ needs thanks to the combination of both mentioned technologies. Starting from the electric demand profile of the final application, this product is designed to “follow” the power profile using the different response of each technology as well as the specific degradation taking into account that this kind of application has to be operative during tens of years. Because of this adjustment available energy is very efficiently used and the final cost of the solution is minimized.

Keywords: energy storage,power,lithium,zinc,electric grid,smart grid,electrochemistry
Metadata Distillery and ExpLoitation System (MoDELS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 1969937.5
EU funding (EUR): 1378956.25
Participants: 1
Project status: CLOSED

Europe's media sector is strong in creating content but lacks behind in embracing new technologies and new business models. Competition from global players that are strong at technological innovation is increasing fast. This puts many jobs, original European content and cultural heritage at risk. The future of broadcasters is in metadata management. This data is used to fuel media applications. These will be the backbone of future television and will be used to schedule programming, interactive programming, video discovery and targeted advertising. But still today, broadcasters rely on manual labelling by editors to tag the key content of their media. The holy grail here is to do this automatically, more extensively and in real-time. We are Media Distillery and we developed a platform that analyses every millisecond of audio and video content in real-time. We produce the most extensive deep media metadata seen in the industry. By using cutting edge deep learning, artificial intelligence and state of the art data mining techniques, our platform filters all relevant information. The current Media Distillery Platform is already well proven in providing Media Metadata services, and we already serve ten international clients. The aim of this project is to enhance and commercialize our Metadata Distillery and ExpLoitation System (MoDELS). This enables the widespread uptake of our Deep content understanding technology and associated applications. In this project we will demonstrate its effectiveness in four media applications at European TV operators. Demonstrating that with our advanced metadata, content catalogues are better managed, content descriptions are more accurate, searching is far more exhaustively and recommendations more useful. Hereby realising business opportunities for TV operators that were unimaginable before. They understand customers better, improve their business processes, increase revenue, reduce costs and improve decision making.

Keywords: deep content understanding,artificial intelligence,television,media applications,big data,data,mining,media mining
Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr (GEMMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Italy,Italy,Finland,Finland,France,United States,Netherlands,United Kingdom
Call: Exploiting research outcomes and application potential of the human microbiome for personalised prediction, prevention and treatment of disease (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 14225757.5
EU funding (EUR): 14225757.5
Participants: 17
Project status: SIGNED

GEMMA will be the first project to combine a multi-omic approach with robust environmental data to exploit the analysis of the composition and function of the microbiome for personalized treatment and, ultimately, disease interception in infants at risk of Autistic Spectrum Disorders (ASD) . The project will provide solid mechanistic evidence of the disease onset and progression in relation to dynamic changes in abnormal gut microbiota causing epigenetic modifications controlling gut barrier and immune functions, based on the in-depth evaluation of 600 infants at risk observed from birth and followed over time. These data will be integrated with pre-clinical studies to mechanistically link human microbiota composition/function with clinical outcome through humanized murine models transplanted with stools obtained from the ASD proband patient of recruited families. The project will support novel personalized prediction (personalized treatment) and disease interception (prevention) approaches that attempt to modulate gut microbiota to re-establish/maintain immune homeostasis. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and the possibility to manipulate the microbiota through pre/pro/symbiotic administration for prevention and treatment, a complete paradigm shift in ASD pathogenesis and early intervention. The identification of specific ASD metabolic phenotypes will further aid to define biomarkers that can be used as diagnostic tools and patient stratification models for other conditions in which the interplay between genome, microbiome and metabolic profile has been suspected or proved. Finally, the project will collect biospecimens from a cohort of 600 infants as risk of ASD observed from birth, generating a unique biobank of 16,000+ blood, stool, urine and saliva samples prospectively collected that can be exploited in future multiomic studies.

Keywords: autism,autistic spectrum disorders,gut dysbiosis,gut permeability,neuro inflammation,multi omics
Next Generation Internet of Things (NGIoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Switzerland,Switzerland,Serbia,Denmark
Call: Internet of Things (H2020-ICT-2018-2, 2018)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 6
Project status: CLOSED

NGIoT is a Coordination and Support Action (CSA) that will create a robust and agile research, innovation and implementation agenda that will lead to unlocking the growth potential of the Internet of Things (IoT) while respecting core European values, supporting key EU policies, leveraging the key associations, and establishing a Strategy Board. The main objective of NGIoT is to mobilise effectively and provide strategic coordination of existing IoT-related stakeholders, organisations, networks, initiatives and projects in preparation of upcoming key European and national industry and research and innovation as well as implementation initiatives. NGIoT establishes a roadmap for European Internet of Things (IoT) research and innovation as well as implementation that addresses the complex situation of IoT in the world today. Furthermore, it shows a way forward based on European values, and it supports key policies such as the Digitizing European Industry (DEI) and the Digital Single Market (DSM) situating IoT in relation to the rest of the technology landscape, including security, Artificial Intelligence (AI), 5G, edge computing, and not least the Next Generation Internet (NGI). The NGIoT ambition reflects a realization that the landscape for deploying human-centred IoT is very dynamic, multi-sectored and multi-faceted, calling for an inclusive and innovative approach to research and innovation. In addition, the NGIoT ambition calls for an implementation strategy and orchestration that can inform and be informed by societal needs, including the need to formulate policy, to create standards and to give guidance on technical feasibility at scale across application domains. The three-year action will interconnect prominent stakeholders and initiatives in the field of IoT in a Strategy Board, supporting the digital transformation of value creation in Europe, across industries, in verticals and in civil society. Liaising between existing initiatives, organizations, sectors and stakeholders, NGIoT will deliver a cross-domain ecosystem approach to establish new directions for research and innovation as well as implementation in IoT, identifying priorities and new horizons for the period of 2020-2027.

Keywords: digitising european industry,research roadmap,ecosystem building,trust,value generation,standards,privacy,security,human centered,next generation internet,interoperability,blockchain
Disruption of systemic and microenvironmental barriers to immunotherapy of antigenic tumors (CAN-IT-BARRIERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The frontier in cancer therapy of orchestrating the immune system to attack tumors is producing unprecedented survival benefit in some patients. The corollary is lack of efficacy both in ostensibly responsive tumor types as well as others that are mostly non-responsive. The basis lies in pre-existing and adaptive resistance mechanisms that circumvent induction of tumor-reactive cytotoxic T cells (CTLs) capable of infiltrating solid tumors and eliminating cancer cells. A priori, cancers induced by expression of human papillomavirus oncogenes should be responsive to immunotherapy: these cancers encode immunogenic neo-antigens – the oncoproteins E6/7 – necessary for their manifestation. Rather, such tumors are poorly responsive to immunotherapies. Results from my lab and others using mouse models of HPV-induced cancer have established an actionable hypothesis: during tumorigenesis, such tumors erect multiple barriers to the induction, infiltration, and killing of cancer cells by tumor antigen-reactive CTLs. These include overarching systemic antigen-nonspecific immunosuppression mediated by expanded populations of myeloid cells in spleen and lymph nodes, complemented by immune response-impairing barriers operative in the tumor microenvironment. A spectrum of models will probe these barriers, genetically and pharmacologically, establishing their functional importance, alone and in concert. A major focus will be on how oncogene-expressing keratinocytes elicit a marked expansion of immunosuppressive myeloid cells in spleen and lymph nodes, and how these myeloid cells in turn inhibit development and activation of CD8 T cells and antigen-presenting dendritic cells. Then we’ll assess the therapeutic potential of barrier-breaking strategies combined with immuno-stimulatory modalities. This project will deliver new knowledge about multi-faceted barriers to immunotherapy in these refractory cancers, helping lay the groundwork for efficacious immunotherapy.

Keywords: immuno oncology,tumor resistance mechanisms to t cell immuno therapy,mechanism guided combinatoric pre clinical cancer trial designs,tumor microenvironment,systemic immuno suppression