Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
GaN in One Module Integrated Converter for EP systems (GaNOMIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Italy,France,France,Canada
Call: SRC - In-Space electrical propulsion and station keeping - Disruptive Technologies (H2020-COMPET-2016, 2016)
Start date: 2016-12-01
End date: 2021-09-30
Duration (months): 58.0
Total project cost (EUR): 1604250.0
EU funding (EUR): 1544160.0
Participants: 9
Project status: CLOSED

Satellite contractors are permanently looking for cost and performance improvements. This cascades to the PPU, a subsystem having a very high impact on the cost and performance of EP systems. Hence, we propose to focus on the PPU “heart” studying a disruptive power converter, with major innovations complementary to the incremental improvements, beyond the state of the art. We will demonstrate and combine in a synergistic way innovative technologies (such as GaN, digital control, adaptive filtering and embedded packaging), thus resulting in a radical breakthrough applicable to advanced EP architectures based on such PPU designs. The consortium plans to demonstrate the selected technologies by means of a 7.5 kW power converter to be tested in electrical propulsion existing test facilities, thus providing measurable validation, and specification definition, within the 2016 Phase 1 time frame. This will lead to dramatic improvements in cost, mass and volume targeting part list reduction (by 3), converter efficiency (98%) and optimized thermal characteristics (200°C), translating into system optimization and increased power requirements. Being at the forefront of technological developments, the consortium members are able to anticipate emerging technologies and medium to long term performance requirements consistent with existing and planned space programs at national, commercial and ESA levels. GaNOMIC will constitute a solid technical basis for future Direct Drive configurations, and further down the line, to “distributed” configurations where the PPU can be eliminated altogether. In addition to promoting and accelerating the development of breakthrough EP-related concepts, the consortium members have identified other markets, e.g. aeronautics and automotive, which could benefit from these innovating high performance power converter and related technologies under consideration. The consortium is committed to continue this study in future calls of the SRC.

Keywords: electric propulsion,digital control,advanced packaging,embedded packaging
Towards an Inclusive Common European Framework for Assisted Reproductive Technologies (ART): Queer Transgender Reproduction in the Age of ART. (QTReproART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The use and regulation of Assisted Reproductive Technologies (ARTs) has undergone repeated significant changes since the 1980s, partly to accommodate biotechnological developments, partly to recognize shifts in socio-cultural practices of kinship and family. These changes have generally been towards greater inclusivity but have been variedly legislated and implemented in the diverse European countries, leading to ‘reproductive migration’. As the numbers of ART users and clinics rise, there is a clear need to provide a common European framework for ART: this is the purpose of this project. One social group particularly affected by ART policies are queer and transgender people. Most research on their use of ART is performed in English-speaking, western European countries, much less in central European ones and virtually none in east European countries - this project will fill that gap. However, eastern Europeans and their clinics play a major role in European ART use through ‘fertility tourism’ and the provision of biomaterials (eggs, sperm, etc.). This 3-stage comparative project will examine the regulation of ART and the experiences of self-identified queer and transgender people with ART in 6 purposely selected European countries: Austria, Estonia, Poland, Sweden, Spain and the UK, in order to draft a more inclusive common European framework for ART. To do so, the ER will work at the Centre for Gender Research (CGR) at Uppsala University, Sweden, analyzing diverse national European ART guidelines and frameworks, collecting original empirical data on queer and transgender people’s experiences of ART, and drafting the framework. Purposive sampling and innovative methods such as community feedback loops will help to create outcomes that impact not only ART research, but importantly on ART policies and legislations, on LGBTQI rights and ART, on LGBTQI people and their families, and on strengthening the EU as a union with common frameworks.

Keywords: queer theory,transgender studies,lgbtiq,assisted reproductive technologies,europe,intersectionality
the eye and ears of the farmer - Smart monitoring system for intensive livestock farming management (Smart Farm 4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The EU livestock sector is the largest in the world, and meat, milk, and eggs make up 40% of the EU’s agricultural production value. It accounts for 48% of total EU agricultural activity, with an estimated €130bn output value annually. The sector has been dealing with numerous challenges such as animal welfare, foreign competition, environmental impact, and antibiotic resistance, but technologies such as Precision Livestock Farming can help face these challenges, as has already been demonstrated by the EU-PLF project. However, existing Precision Livestock Farming (PLF) solutions on the market are not being adopted by farmers due to the complexity of the technology (e.g. different software for different hardware, sensor data in different formats), the lack of support, data storage limited capacities, and the difficulty interpreting and visualizing gathered data. Thus, due to their poor design, not having in mind end-users' technological limitations, these systems can't really translate into productivity gains, nor provide a return on investment in the short-term, which is the overriding reason to adopt PLF. Paintec SL, company specialized in providing services for the agricultural sector based on technologies and Big Data analysis, has developed SmartFarm 4.0, aware of the value data can have for farmers and other stakeholders in the supply chain. SmartFarm 4.0 is a PLF cloud-based platform integrating the hardware needed for a complete 3600 monitoring of the farm with a single software. Relevant data from the farm is presented to the user through an intuitive dashboard with alerts in those areas that need attention, so that the user can take immediate action. By understanding the data, farmers can take action, thus our system really translates into a ROI of more than €2 per euro invested. Additional advantages from our solution are unlimited data storage, improved data security, easy access to data by other stakeholders, periodic updates and full customer support.

Keywords: animal welfare,thermography,sounds,big data,farm applications,ghg emissions
Renal iron homeostasis tackles with glucose metabolism to confer disease tolerance in malaria infection (RIGM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Disease tolerance is pivotal for host survival in malaria. In particular, Heme/iron metabolism in parenchymal tissues, such as liver, kidney, implicates in tissue damage and metabolic reprogram during infection diseases including malaria and sepsis, etc. Therefore, heme/iron metabolism is potential target for disease tolerance modulation in treating malaria and sepsis. In support of this notion, the host lab previously found that Ho-1 and ferritin heavy chain in the kidney are important in mice fighting against malaria. Meanwhile, the underlying mechanism of heme/iron affecting organ metabolism and host homeostasis is not well understood. Studies indicated that ferroptosis cascade involves in heme/iron-driven tissue damage and other metabolic alterations. Accordingly, we intend to address the interface of ferroptosis and glucose metabolism in kidney during malaria. Malaria iwill be applied to iron exporter, Ferroportin (Slc40a1) deletion specific in renal proximal tubule epithelial cells(RPTEC) (Slc40a1 PepckΔ/Δ ). Basic disease trajectory phenotype and ferroptosis parameters will be collected to demonstrate the impact of RPTEC iron export on kidney injury and systematic homeostatic status during malaria. Based on our preliminary data, Slc40a1 PepckΔ/Δ mice are sensitive to malaria due to disease tolerance collapse which displays as lethal hypoglycaemia and temperature drop. We propose to manipulate ferroptosis cascade to ameliorate tissue damage and re-establish disease tolerance in Slc40a1 PepckΔ/Δ mice. Furthermore, we aim to investigate to interface between ferroptosis cascade and glucose metabolism. Not only will a pivotal role of renal glucose production fine-tuned by heme/iron metabolism be uncovered. Transcriptome and metabolomics will be employed to identify novel pathway/metabolites that tackle both ferroptosis and glucose metabolism. The future potency of this study, is to provide therapeutic target in treating malaria.

Keywords: renal iron homeostasis,glucose metabolism,malaria
Climatic impacts of volcaninc ash electrification (ElectricVolcano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 165085.44
EU funding (EUR): 165085.44
Participants: 1
Project status: SIGNED

Volcanic eruptions affect the Earth’s climate by altering radiation balance through the injection of aerosols in the stratosphere. Conventional knowledge assumes that volcanic influences on climate are mediated by sulfate aerosols only. Recent space-based measurements, however, have challenged this assumption by providing definite evidence that the stratospheric aerosol layer is actually a mixture of sulfates and ash for many months after the eruption. This project aims to understand the unknown processes responsible for the prolonged residence time of the volcanic ash in the stratosphere and to assess its climatic impact. Our main hypothesis is that electric charges of the volcanic plume are responsible for keeping volcanic ash aloft. Charge separation in the volcanic plume induces a local electric field and a force that counteracts the ash particle weight, thus reducing its settling velocity and prolonging its lifetime. ElectricVolcano will combine state-of-art remote sensing techniques, detailed aerosol charging theories and comprehensive atmospheric modelling to provide for the first time a thorough assessment of the impact of electrification on the life cycle of volcanic ash in the stratosphere. Through cutting edge inter-interdisciplinary research, the project produces a step change in the way volcanic eruptions are treated by modelling centers and inter-comparison studies, with the potential to significantly reduce uncertainties in natural forcing and near-term predictions. Carefully-designed research and training activities, combined with the world-class excellence on aerosol-electrification research of the Host Institute, guarantee the success of the proposed project. ElectricVolcano provides new knowledge, tools and resources to the Experienced Researcher for expanding significantly his research horizon and boosting his professional independence.

Keywords: volcanic ash,atmospheric electrification,triboelectrification,climate modelling,remote sensing
A Systems medicine approach to chronic inflammatory disease (SYSCID)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Germany,Switzerland,Belgium,Croatia,Belgium,Greece,Croatia,Denmark,United Kingdom,United Kingdom,Luxembourg
Call: Multi omics for personalised therapies addressing diseases of the immune system (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-09-30
Duration (months): 69.0
Total project cost (EUR): 16018111.25
EU funding (EUR): 14456236.25
Participants: 17
Project status: CLOSED

The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses. Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts. Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique "core disease signatures” which are associated with the disease state and independent of temporal variation, (ii) the generation of "predictive models of disease outcome"- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) "reprogramming disease"- will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool . Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g. to alleviate macrophage polarization defects.

Keywords: inflammation,rheumatology,gastroenterology,microbiome
Quadratic dispersive resonators for optical frequency comb generation (QuadraComb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1579213.0
EU funding (EUR): 1579213.0
Participants: 1
Project status: CLOSED

Optical frequency combs are made of thousands of equally spaced spectral lines, each an ultra-stable laser in its own right. They act as “spectral rulers” against which unknown optical frequencies can be measured, and they have had a revolutionary impact on numerous fields ranging from the detection of extra-solar planets to precision metrology, winning its inventors a Nobel prize in 2005. Traditionally, frequency combs have been generated by ultrashort pulsed lasers, but in 2007 an important observation changed the research landscape: a continuous-wave laser coupled into a microscopic resonator was shown to spontaneously transform into thousands of comb lines via third-order nonlinear optical effects. I believe that yet another revolution lies at the horizon. Specifically, recent experiments have alluded to the possibility of realizing optical frequency combs purely through second order (quadratic) nonlinear effects. The intrinsic features of the second order nonlinearity hold promise to deliver access to new regions of the electro-magnetic spectrum beyond all conventional frequency comb technologies. But unfortunately, experimental investigations are scarce and the physics that underlie frequency comb formation in quadratic resonators is poorly understood. The goal of the QuadraComb project is to pursue a complete characterization of frequency comb generation in dispersive quadratically nonlinear resonators. I plan to (i) develop theoretical models to describe quadratic frequency combs, and (ii) develop novel platforms for the experimental realization of quadratic frequency combs.

Keywords: parametric oscillators and amplifiers,optical resonators,frequency conversion
The evolution of menstruation in primates (EVOMENS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1185250.0
EU funding (EUR): 1185250.0
Participants: 1
Project status: SIGNED

Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometrium is reabsorbed at the end of the cycle instead of being shed when fecundation has not occurred. The molecular and genetic underpinnings of this complex process are not fully understood, despite its critical involvement in gynaecological conditions. I propose to discover the molecular mechanisms leading to menstruation by comparing the uterine linings from five primate species at the cellular, functional and genetic levels. The objectives are to identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates, and to understand how this genetically inherited trait was acquired in primate genomes during the evolution of the human lineage. In Aim 1, I will leverage single-cell transcriptomics to uncover the cellular composition and marker modifications that differentiate the uterine linings of menstruating and non-menstruating primates. In Aim 2, I will use deep transcriptomics and accessible chromatin assays on sorted endometrial cell populations to identify genes and non-coding regulatory regions differentially activated in menstruating species. This analysis will reveal the molecular pathways, regulation networks and cellular interplay involved in uterine tissue shedding vs. reabsorption. In Aim 3, I will replace these modifications within the context of primate genome evolution: I will elucidate the mutational dynamics by which genetic novelty has emerged during the adoption of menstruation, and how the functional divergence of the endometrium compares to other reproductive and somatic tissues. This project will enhance our understanding of a key physiological trait for human reproduction as well as a dramatic example of functional innovation in the primate lineage.

Keywords: comparative genomics,functional genomics,evolutionary genomics,primate evolution
Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury (NovelKnees)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

Keywords: subchondral bone,microdamage,bone cartilage crosstalk,remodeling,microparticles,intra articular,drug delivery