Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Single Photon source and detector based on novel materials for the detection of endocrine disruptors (GREENER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,Italy
Call: Innovative materials for advanced (nano)electronic components and systems (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 3759104.0
EU funding (EUR): 3759104.0
Participants: 8
Project status: SIGNED

Water is one of the most important natural resources on earth and despite increasingly strict regulations, contamination of water that poses a health risk is still a major problem. In Europe, too, our drinking water is exposed to contaminants such as hormones, which even in extremely low concentrations can have effects on humans and animals and are therefore of interest for water monitoring in the context of nature conservation and also various branches of industry. Our goal in this project is to provide the layperson with a ready-to-use, compact, and robust spectrometer capable of measuring extremely low concentrations in the sub ng/L range. To this end, the GREENER project aims to develop new, environmentally friendly QDs capable of near-infrared absorption measurements at emission wavelengths as short as 2µm. These will be singulated by the DNA origami method and integrated into an LED layer stack to synthesize a novel kind of single-photon source. Combined with advanced single-photon detectors enabled by new detector materials that do not require expensive cryogenic coolers but rely on simple thermoelectric cooling, a setup for low-loss, low-noise and high-performance spectroscopy for the Vis to NIR range will be developed. The resulting biosensor will subsequently be evaluated for the detection of critical (endocrine disrupting) contaminants in water in fisheries and aquaponics and will enable end-users to monitor water safety and quality on-side without additional infrastructure or trained personnel.

Keywords: quantum dot,dna origami,single photon source,single photon detector,photonics,biosensor,nir spectroscopy
Media, Economics and Geopolitics (MEGEO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1496833.75
EU funding (EUR): 1496833.0
Participants: 1
Project status: CLOSED

Research in political economy has documented a vast number of different “media effects” suggesting that the media can have a profound impact on a range of economically & politically relevant outcomes. Yet, the existing empirical work is significantly skewed towards a few countries, raising concerns about the generalizability & broader cross context relevance of the empirical findings. Further, given the predominant focus on individual countries and its politics, this implies limited attention is devoted to the frictions between national media, national politics and transnational policy making in the myriad of areas that require collective and coordinated global action. To what extent the primarily national media has concrete effects undermining global policy making across a broad range of areas - or on the specific issue of climate change - is an important empirical question that requires both suitable data and suitable research designs. MEGEO will deliver on both dimensions and in the process catalyse research across multiple disciplines. The overarching objectives of MEGEO are: 1) To develop & make available a comprehensive and consistent novel data resource measuring what national media reports on and how and to what extent other countries are represented in each other's media 2) To characterize the extent to which national media may affect policy making in domains with clear transnational relevance that has previously been mostly ignored 3) To quantify the extent to which skewed reporting on foreign countries may have tangible economic & political impacts The work is organized across three work packages that will provide a systematic "Topology of Media Focus" across countries; answer the question of "What, where and why does news spread to?; study "(How) Does National Media Shape Transnational Politics?"; and explore "(How) Does National Media Affect Cross Border Economic Activity?" using a range of novel applications and leveraging proprietary secondary data.

Keywords: political economy,media
Understanding the complex biology of AHR activation in cancer (CancAHR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1999925.0
EU funding (EUR): 1999925.0
Participants: 1
Project status: SIGNED

The aryl hydrocarbon receptor (AHR) is a critical regulator of tumor progression by modulating both tumor cell intrinsic malignant properties as well as anti-tumor immunity. However, depending on the context, the AHR can exert either tumor-promoting or tumor-suppressive effects, thus limiting its potential as a drug target. To exploit the AHR for cancer therapy a comprehensive understanding of its activation and biological outcomes is necessary. The opposing effects of the AHR in cancer likely stem from the complexity of its activation and biological functions, which are cell type-, ligand-, and context-specific. Moreover, recent results from our laboratory suggest that nutritional stress conditions also affect AHR activity. The detection of AHR activation in tissues mainly relies on the quantitation of AHR target gene expression. However, until recently, the context specificity of AHR target gene expression had impeded systematic investigation of AHR activity across human cancers. Our team has developed a pan-tissue AHR signature that detects AHR activity irrespective of cell type or ligand, and enables the analysis of the biological functions mediated through AHR activation. The combination of the AHR signature with iterative cycles of computational biology analyses and laboratory experimentation puts us in a unique position to investigate AHR activation and its downstream effects. CancAHR will hence systematically delineate how the AHR is activated in cancer, why AHR activation is cell type-specific, and which AHR downstream mediators drive clinical outcomes. The identification of the molecular mechanisms underlying the diverse outcomes of AHR activation in cancer will enable (i) the identification of patients, in which AHR activation contributes to clinical outcome; (ii) the development of clinical interventions tailored to the specific mechanisms of AHR activation; and (iii) stratification of patients to precision therapies modulating AHR activity.

Keywords: aryl hydrocarbon receptor,amino acids,metabolism,cancer cell motility,immune cells,transcriptional signature,protein protein interaction,posttranslational modification,epigenetics,predictive biomarker,therapeutic target
Life is Science in a World turned Upside-Down (LiS-World)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Austria
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 318373.13
EU funding (EUR): 300002.7
Participants: 4
Project status: SIGNED

Our public events, held in conjunction with the European Researchers’ Night (ERN) in Graz, Austria, will be titled "Life is Science in a World turned Upside-Down" (Lis-World). The title signifies our central objective – to showcase the vital role of science in navigating the complexities of today's world. In the face of (emerging) global challenges, public engagement for a more informed, sustainable, and scientifically-literate society is paramount. Attendees will gain firsthand insights into the daily work of researchers and science communicators across various science disciplines, highlighting the profound impact of science on our daily lives. The event’s framework centers around four distinctive storylines: Earth Explorers, Health Investigators, Tech Pioneers, and Science Reporters. These designations are chosen not only to pique the attendees' individual interests, but also to directly engage them in specific roles and give them the opportunity to earn a badge, for example, as a "Science Reporter”. This immersive approach encourages active participation, ensuring that each visitor can directly experience the heart of these scientific domains.

Keywords: open science event,life sciences,digitization,science communication,science scepticism
Developing & piloting biodiversity footprinting & natural capital accounting via a 'beehive' of sectoral hubs, for sustainable transition to a circular EU bioeconomy (CircHive)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Finland,Bulgaria,Netherlands,Belgium,Italy,Ukraine,United Kingdom,South Africa,France,Germany,Sweden,Austria,Spain,Switzerland,Greece,Luxembourg
Call: Natural capital accounting: Measuring the biodiversity footprint of products and organizations (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 9013661.5
EU funding (EUR): 7969963.5
Participants: 30
Project status: SIGNED

Biodiversity is the true driving force of a sustainable, circular bioeconomy (CBE). While the CBE needs advanced technology and innovation to succeed, biodiversity determines the capacity of biological systems to adapt and evolve. For this reason, biodiversity considerations need to be reflected in economic practices and valuation. CircHive will measure and integrate the value of nature into public and business decision making by: 1) improving data availability, accessibility, and harmonisation; 2) developing a standardised method for biodiversity footprinting (BF) and integrating it with natural capital accounting (NCA); 3) mainstreaming the use of BF and NCA in public and private decision making, incl. improving disclosure, risk management, and investment practice; 4) testing and improving the developed methods and models; and 5) building a wider community ‘BEEHive’ for peer support and exploitation of results. A strong emphasis is put developing scientifically robust and standardised methods that bridge BF (life cycle analyses) and NCA (bookkeeping), given their multiple overlaps but also divergences that hinder operationalisation and uptake. An equally strong emphasis is placed on practice-testing to understand current practices and opportunities for further mainstreaming of biodiversity and natural capital into disclosure, ecolabelling, and investment decisions. Transitioning theory to practice is put to the test via a case study network who will apply different biodiversity-centric approaches in real life. This is carried out in sectoral case study hubs (industry, retailers, investors, cities) for peer learning and capacity building. In CircHive’s approach, CBE and biodiversity reinforce each other as a basis for resources and inspiration for sustainable business practices. The integration of the value of nature into public and business decisions, will benefit both the protection of ecosystems and their services and the profitability of sustainable businesses.

Keywords: biodiversity footprinting,natural capital accounting,corporate sustainability reporting,sustainable business models,sustainable finance,circular bioeconomy,natural resources,
Process Attribution of Regional Emissions (PARIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Switzerland,United Kingdom,Norway,Italy,Ireland,Hungary
Call: Verification and reconciliation of estimates of climate forcers (HORIZON-CL5-2022-D1-02, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3526154.5
EU funding (EUR): 3526154.5
Participants: 17
Project status: SIGNED

There are only a few countries worldwide, and only two in Europe (the UK and Switzerland, via our team), who routinely report their emissions using bottom-up (inventory) and top-down (atmospheric data-based) methods together. The central aim of PARIS is to significantly increase the uptake of this joint approach to emissions evaluation. We target research areas that have been shown, through our previous successes, to be of high value to inventory compilers, or have been only partly explored in previous projects. To engage inventory teams early in the project, we focus on new emissions estimates for fluorinated gases (F-gases), which have relatively simple source distributions, but poorly understood magnitudes. We will extend to eight countries across Europe our proven approach in using top-down constraints to evaluate inventory F-gas models. For greenhouse gases (GHGs) with a more complex mixture of sources, methane and carbon dioxide, research in PARIS focuses on the attribution of fluxes to particular sources and sinks. We will advance our world-leading isotopologue measurements and tracer-based analysis methods, providing inventory teams with new information to target areas of uncertainty. For nitrous oxide, a GHG for which most European inventories rely on highly simplified and uncertain bottom-up methods, two process-level models will be advanced to produce time- and space-resolved estimates that will be evaluated against isotopic data. For the important, but complex, climate forcers, organic matter aerosol and black carbon, we will take the next steps required towards robust top-down emissions inference by developing source apportionment methods. To generate maximum impact, we will synthesise these advances in the form of draft annual Annexes to National Inventory Reports (NIRs) for eight PARIS focus countries. If adopted, this will represent almost a quadrupling of the number of countries globally that include top-down emissions estimates in their NIRs.

Keywords: greenhouse gas,climate forcer,evaluation,inventories,bottom up,top down
MARine COastal BiOdiversity Long-term Observations (MARCO-BOLO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: France,Belgium,Germany,Spain,Norway,Romania,Italy,Denmark,Ukraine,Portugal,Ireland,Austria,United Kingdom,Sweden
Call: Observing and mapping biodiversity and ecosystems, with particular focus on coastal and marine ecosystems (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 7255037.5
EU funding (EUR): 7255036.75
Participants: 28
Project status: SIGNED

MARCO-BOLO (MBO) aims to structure and strengthen European coastal and marine biodiversity observation capabilities, linking them to global efforts to understand and restore ocean health, hence ensuring that outputs respond to explicit stakeholder needs from policy, planning and industry. To this end MBO will establish and engage with a Community of Practice (CoP) to determine end-user needs with the aim of optimising marine data flows, knowledge uptake, and improving governance based on biodiversity observations. By exploiting synergies with concurrent projects MBO will develop and demonstrate new autonomous technology for biodiversity mapping and monitoring, and data streams from remote sensing, eDNA, robotics, optical and acoustic observations. Protocols for eDNA-based biodiversity observations are established and validated across applications, taxa and ecosystems. The sequence of the analytical and technical processes for the different use cases will be incorporated into operational Essential Ocean Variables (EOVs) and Essential Biodiversity Variables (EBVs) and included into online reusable workflows, contributing to the free and open access of EU and global biodiversity information facilities, and to support major EU biodiversity directives and global initiatives. The project partnership will leverage its international activities (MBON, GOOS, OBIS) and participation in UN Ocean Decade Programmes (Marine Life 2030, OBON, ODIS, Ocean Practices for the Decade) to align the MBO work programme to global CoP, ensuring European participation and leadership in global biodiversity monitoring and global science. MBO results will be designed to build upon existing capability and infrastructures, and to be relevant to existing frameworks so that outputs can be easily integrated into national, regional (EU and adjacent sea basins), and global observation systems, with no delay ensuring the reusability of the investments Europe is already making in data generation.

Keywords: marine and coastal biodiversity management and data processing
2D Material-Based Multiple Oncotherapy Against Metastatic Disease Using a Radically New Computed Tomography Approach (PERSEUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Sweden,Israel,Spain,Hungary,United Kingdom
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2740675.0
EU funding (EUR): 2740675.0
Participants: 7
Project status: SIGNED

PERSEUS intends to implement a novel nanotechnology-based cancer therapy for deep-seated clinically unmanageable, drug-resistant and metastatic tumours. Practical use of nanotechnology in clinical cancer care is still in its infancy with a full potential yet to be realized. The therapy is based on a novel nano-system (NS) made of multifunctional 2D layered nanocrystals. The NS enables, under activation by computed tomography (CT), an effective multimodal therapy with minimal or no adverse effects. This novel paradigm uses CT not to eradicate cancer, but to trigger and to image the NS that locally activates non-mutagenic oncotherapies. The therapies delivered are excited by the conversion of low energy X-rays (i.e., CT) into heat, reactive oxygen species and radiosensitizing agents. X-ray irradiation can also induce immunogenic cell death with the exposure or release of neo-antigens to trigger an anti-cancer immune response. The use of X-rays makes it possible to reach deep-seated tumours that are inaccessible by visible or near-infrared light-based therapies. In other words, CT is the spark that lights the match. This is a radical vision for an ambitious and high-risk project. The current proposal targets a range of cancer types including metastatic triple negative breast cancer, hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma. The NS is biocompatible and also totally inactive in absence of CT radiation, i.e. the NS becomes active only where the CT beam is delivered so minimizing side effects at distal sites. The therapy is agnostic to the type of cancer and to gender incidence because it doesn't affect the body biochemistry. This is a second change of paradigm. PERSEUS vision is pursued by a multidisciplinary team composed of physicists, chemists, chemical engineers, biologists, physicians, pharmacologists and radiologists working together to develop an innovative nanotechnological approach to address unmet clinical needs.

Keywords: nano vehicle,2d layered materials,computed tomography,metastatic disease,x ray induced photo dynamic therapy,x ray induced thermal therapy,x ray induced immunotherapy and radiosensitization
Intelligent digital toolbox towards more sustainable and safer extraction of mineral resources (NETHELIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Germany,Poland,Greece,Belgium,Cyprus,Austria,Bulgaria,Switzerland,Finland
Call: Sustainable and innovative mine of the future (IA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 14939668.75
EU funding (EUR): 11145398.63
Participants: 26
Project status: SIGNED

Europe’s industry and economy depend on a secure access to many commodities. In 2020, the EC updated its list of critical non-energy non-agricultural raw materials (CRMs), based on scarcity of supply and importance to EU industry. Today, the list includes: Antimony, Fluorspar, Magnesium, Silicon Metal, Baryte, Gallium, Natural Graphite, Tantalum, Bauxite, Germanium, Natural Rubber, Titanium, Beryllium, Hafnium, Niobium, Vanadium, Bismuth, HREEs, PGMs, Tungsten, Borates, Indium, Phosphate rock, Strontium, Cobalt, Lithium, Phosphorus, Coking Coal, LREEs, Scandium. Securing sustainable access to CRM, is of high importance for the EU economy. However, the EU is confronted with a number of technological and environmental challenges along the entire production value chain of primary and secondary raw materials. NetHelix demonstrates in real life settings a toolbox of new technologies for automating and streamlining the extraction process, taking advantage of deposits through mining and waste deposits processing methods, maximising efficiency, reducing waste production, and increasing environmental and huma health and safety.