Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Triangulated categories and their applications, chiefly to algebraic geometry (TriCatApp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 1042645.0
EU funding (EUR): 1042645.0
Participants: 1
Project status: SIGNED

There are two components to this project. (1) Develop and extend the striking new theory, created by the PI in the last few years, which studies triangulated categories via metrics and approximations. (2) Build on very recent work to better understand which functors are Fourier-Mukai and which aren't. In the case of (1), the novel idea of appropriately using metrics has already allowed the PI to prove several difficult conjectures, the most recent just a few weeks ago. The potential of the new theory is immense, and this project aims to extend the scope of the methods and apply them widely. The project also aims to work out the implications of a surprising theorem proved by the methods, which shows that the derived category of perfect complexes and the bounded derived category of coherent sheaves are constructible from each other, as triangulated categories, by an explicit recipe. This theorem flies in the face of accepted wisdom, which viewed the two categories as totally different. Thus a whole body of work, analysing the many differences between these derived categories, needs to be carefully revisited and reconsidered in the light of the new construction. The Fourier-Mukai transforms of (2) have a long and venerable history, with beautiful work by many authors. But there were novel techniques introduced in a couple of recent articles, and the project plans to deploy them more widely. The aim is for a breakthrough in the area, leading to a better understanding of which exact functors are Fourier-Mukai and which aren't.

Keywords: derived categories,triangulated categories,enhancements
Engineering the immune response in Parkinson’s disease to curb its pathological progression (CARgiver)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2493000.0
EU funding (EUR): 2493000.0
Participants: 1
Project status: SIGNED

Mounting evidence has defined the key role played by the immune system in exacerbating dopaminergic neuron loss in Parkinson’s disease (PD). Pathological alpha-Synuclein (αSYN) activates microglia and recruits inflamed T cells, creating a toxic environment that directly negatively impact on neurodegenerative processes. Blocking or attenuating neuroinflammation can have a strong therapeutic potential in PD, but systemic treatments are associated with immune system general suppression leading to severe and unacceptable side effects. Therefore, a therapeutic strategy for long-term and local immune suppression would minimize adverse effects and provide a long-sought disease-modifying treatment for PD. To achieve this goal, we have generated αSYN-specific CAR T regulatory cells (Tregs) that are activated and recruited only in the presence of toxic αSYN aggregates, suppressing immune activation. Herein, we will determine the therapeutic efficacy of mouse and human αSYN-CAR Tregs in conventional and humanized mice with virally-induced synucleinopathy. These experiments will determine the dose and infusion schedule that will achieve maximal neuroprotection and symptomatic rescue with none or minimal side effects. Moreover, innovative all-human neuroimmune organoids will be generated by assembling patient and isogenic iPSC-derived neural, astroglial and microglial cells together with freshly isolated T cells and αSYN-CAR Tregs. This model will recapitulate human-specific neuroinflammatory processes and validate the capacity of αSYN-CAR Tregs to interfere with them. Finally, we conceived αSYN-CAR Tregs as ideal cellular shuttles for the local delivery of therapeutic molecules and this concept will be explore to express αSYN anti-aggregating agents. This treatment is of potential benefit for the entire PD patient population at any given stage of the disease and pharmacological regimen, and with a straightforward clinical implementation path using an autologous cellular source.

Keywords: parkinson s disease,alpha synuclein,neurodegeneration
Protest as a Democracy Test: Protest Culture under Transformation and as a Transformative Power (ProTest)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Sweden,Spain,Romania,Georgia,Portugal,Germany,Italy,Poland,Hungary
Call: Protest politics and cultures of opposition in democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2737955.0
EU funding (EUR): 2737955.0
Participants: 9
Project status: SIGNED

There is a steady trend of global democratic decline (de-democratization), transforming political opportunity structures and creating new knowledge gaps about how protest cultures evolve and adapt to changing contexts. Addressing this gap, the project's aim is twofold: First, to reveal whether and how ongoing de-democratization processes affect patterns of protest culture and how these effects vary according to democracy (consolidated, new and developing); second, to trace whether and how affected patterns of protest culture influence the state of democracy in target countries, by focusing on representation as inclusion of citizen preferences in political agendas. Research findings will shed light on two dimensions of protest culture, particularly its internal capacity and its external constraints. This will be done via analyzing historical contexts of variations in protest cultures across different types of democracy, factors intersecting to trigger or shape pro-democratic/anti-democratic protests, political elite manipulation of legal and discursive frames to curtail public discontent, role of traditional and social media creating opportunities or obstacles for actors engaged in contentious politics, generational differences in perceptions of and participation patterns in protest culture, and finally, influence of protest culture itself on the state of democracy through representation as an outcome of civic participation. The interdisciplinary project relies on methodological pluralism and integrates: desk research and legal analysis, biographical narrative interviews and focus groups, quantitative and qualitative content analysis, critical discourse analysis and visual analysis, network analysis for mapping actor-discourse coalitions, and Q methodology. The project responds to the work program “Culture, Creativity and Inclusive Society” by addressing (un)conventional citizen participation for better representation in different cultural and democratic settings.

Keywords: protest culture de democratization
Novel biomarkers of pollution in avian models: Paternally-transmitted Epigenetic Alterations in Response to heavy metaL exposure (PEARL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-03
End date: 2025-04-02
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: CLOSED

With the PEARL project, I will investigate the role of non-genetic inheritance in the response of birds to polluted environments. Hosted at the University of Jyväskylä and supervised by Dr. Suvi Ruuskanen, a prominent figure in the field of environmental physiology, this project will be the first to shed light on paternally transmitted effects of pollution in avian models. Its originality resides in an integrative approach to the effects of heavy metal pollution, combining life history studies, physiology and epigenetics applied to an experimental poultry model and to wild passerines. The combination of an experimental approach and a fieldwork study will allow to 1) gauge the extent to which heavy metals can affect morphological and molecular traits in paternal sperm and their transmission to offspring, and 2) validate sperm molecular traits as biomarkers of heavy metal exposure. Aligned with one of the key strategic orientations for greater impact of Horizon Europe to preserve European biodiversity, PEARL aims to identify novel biomarkers of pollution exposure, thus bringing crucial knowledge for future research and monitoring of the impacts of heavy metal pollution on ecosystem health and for bird conservation. The project will be key in advancing my career by enabling a two-way transfer of knowledge and skills with the Host institution through a carefully crafted training plan, and a strong emphasis on dissemination and communication with a broad panel of actors (academics, conservation managers, non-scientific public).

Keywords: non genetic inheritance,sperm,bird,heavy metals
Neural OmniVideo: Fusing World Knowledge into Smart Video-Specific Models (OmniVideo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SUSPENDED

The field of computer vision has made unprecedented progress in applying Deep Learning (DL) to images. Nevertheless, expanding this progress to videos is dramatically lagging behind, due to two key challenges: (i) video data is highly complex and diverse, requiring order of magnitude more training data than images, and (ii) raw video data is extremely high dimensional. These challenges make the processing of entire video pixel-volumes at scale prohibitively expensive and ineffective. Thus, applying DL at scale to video is restricted to short clips or aggressively sub-sampled videos. On the other side of the spectrum, video-specific models—a single or a few neural networks trained on a single video—exhibit several key properties: (i) facilitate effective video representations (e.g., layers) that make video analysis and editing significantly more tractable, (ii) enable long-range temporal analysis by encoding the video through the network, and (iii) are not restricted to the distribution of training data. Nevertheless, the capabilities, applicability and robustness of such models are hampered by having access to only low-level information in the video We propose to combine the power of these two approaches by the new concept of Neural OmniVideo Models: DL-based frameworks that effectively represent the dynamics of a given video, coupled with the vast knowledge learned by an ensemble of external models. We are aimed at pioneering novel methodologies for developing such models for video analysis and synthesis tasks. Our approach will have several important outcomes: • Give rise to fundamentally novel effective video representations. • Go beyond state-of-the-art in classical video analysis tasks that involve long-range temporal analysis. • Enhance the perception of our dynamic world through new synthesis capabilities. • Gain profound understanding of the internal representation learned by state-of-the-art large-scale models, and unveil new priors about our dynamic.

Keywords: computer vision,video analysis,video editing,content creation,video synthesis,video decomposition,layered video representations,video re rendering
UNveiling dynamics of Rapid Erosion through advanced Seismic Techniques (UNREST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1771915.0
EU funding (EUR): 1771915.0
Participants: 1
Project status: SIGNED

Floods and landslides are an intensifying hazard in the context of climate change that affected over 2 billion people worldwide between 1998-2017. In mountainous catchments, these processes play a significant role in rapid erosion contributing to landscape evolution. Yet, multiple barriers limit our current understanding of rapid erosion dynamics, such as the applicability of theoretical transport laws to complex real-world systems, poor understanding of the mechanism behind the initiation of rapid erosion processes, and sparsely distributed observations in time and space. The UNREST project will cut this Gordian knot by pioneering an interdisciplinary observational framework that integrates several state-of-the-art seismic techniques (spatially dense arrays, seismic interferometry, and machine learning) with physical and numerical models on a previously unexplored spatiotemporal scale. This will be done through three main objectives: (1) identify precursors and magnitude indicators of impending landslides, (2) link seismic signals to complex landslide dynamics, and (3) develop new tools to track unstable flood flow across multiple scales. The project will be conducted in four active Alpine catchments in France and Switzerland, with the developed methods tested in an entirely different geomorphic, geologic, and climatic setting of New Caledonia, a South Pacific island. UNREST will unveil critical thresholds in damage development on unstable slopes and previously unobserved patterns and behaviors in complex flow dynamics. These findings, augmented by the development of near-real time data processing workflows, will have a transformative impact on the understanding of rapid erosion dynamics, paving the way to enhanced warning systems in mountainous catchments.

Keywords: environmental seismology,erosion,mountainous catchments,landslides,floods,sediment transport,granular flow dynamics,advanced seismic methods,distributed acoustic sensing,dense seismic arrays
Philosophical, Logical, and Experimental routes to substructurality (PLEXUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Portugal,Italy,France,Netherlands,United Kingdom,Argentina,Australia,United States
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 556600.0
EU funding (EUR): 556600.0
Participants: 10
Project status: SIGNED

There is a large family of non-classical logics that fall under the heading of substructurality. Among the logics in the substructural family, the recent philosophical literature pays particular attention to what can be termed “radically substructural logics”: non-transitive and non-reflexive reflexive logics as well as variants and hybrids of these obtained by metainferential ascent. The overall goal of PLEXUS is to advance the knowledge of radical substructural logics and deepen our understanding of the broader phenomenon of substructurality, by coordinating the efforts of researchers across the globe, across generations, and across traditions. We see our project characterised by the following concepts: integration, cross-fertilization and knowledge sharing. This general objective is articulated in three objectives: 1. Philosophical Foundations: investigate the main philosophical challenges raised by radically substructural logics. 2. Logic and applications: investigate proof-theoretic and model theoretic characterizations of radically substructural logics and their logico-linguistic applications. 3. The Metainferences Inventory and Metainferences Prover: develop a tool to measure naïve reasoners' preferences on metainferences and implement an automatic metainferences prover.

Keywords: philosophical logic,substructural logics,paradoxes,metainferences,experimental philosophy,psychometric tools
Commercial maturation of MedicQuant (MedicQuant)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Denmark
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

MedicQuant is an in vitro diagnostic company where we have invented a deep-tech platform technology that will revolutionize small molecule diagnostics. Our first product, DoaQuant, focuses on improving stroke management. In the event of stroke rapid treatment is vital for survival and every minute matters. It is crucial to determine the level of anticoagulant (AC) drugs in these patients, as this determines which lifesaving treatment can be given. Current diagnostic solutions take more than 40 minutes thus risking patients’ lives. DoaQuant can rapidly provide clinicians with the answer they need to determine the correct life-saving management in stroke, thus greatly reducing delay in treatment, mortality, and disability. Dr. Line Debois is CEO and co-founder of MedicQuant and has, through her academic career, researched biosensors concluding in the co-invention of the technology behind MedicQuant. She has taken the position of CEO in MedicQuant since incorporation, with the vision to lead the company to success and make a difference in the healthcare system. The overall goal with the activities performed during the Women TechEU program is commercial maturation of MedicQuant and preparing for VC fundraising. This will be achieved through specific tasks and by further developing CEO Line’s commercial and leadership skills. The specific activities to achieve this is making a market access strategy (through reimbursement analysis, regulatory strategy, pricing strategy and willingness to buy), preparation of documentation portfolio for investment and further developing commercial skills through the mentoring program that are needed for VC fundraise and manage a company in growth. This program will directly help overcoming the most crucial commercial challenges that both MedicQuant and Line as CEO are currently facing, thereby enabling MedicQuant to become a female lead success, empowering women in deep-tech and fostering further diversity in the life-science sector.

Keywords: medtech,diagnostics,point of care,stroke
Carreras Postdoc Program Empowering Future Leaders to Fight Blood Cancers (CarrerasLeaders)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Germany,Italy,Netherlands,United Kingdom,Switzerland,United States,Norway,Czechia,Belgium,Hungary,Portugal,United Arab Emirates
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2028-12-31
Duration (months): 72.0
Total project cost (EUR): 2292480.0
EU funding (EUR): 2292480.0
Participants: 47
Project status: SIGNED

CarrerasLeaders is a new innovative and international postdoctoral programme, designed by Josep Carreras Leukaemia Research Institute (IJC), an independent, non-profit biomedical research institute that is part of the Government of Catalonia network of Research Centres (CERCA). IJC is the first European institute exclusively devoted to leukaemia and other malignant blood diseases. The aim of the programme is to fund 16 excellent postdoctoral researchers for a period of 36 months. The selection of the fellows is merit-based, founded on peer review in an open and transparent selection procedure. Carrerasleaders is addressed to boost career perspective of researchers from a three-dimensional perspective: leadership, independence, and consolidation. This is a world-wide unique postdoctoral program that covers the entire spectrum of research and innovation in blood cancers and goes from understanding disease biology to the implementation of products and processes in the market and into the clinical practice through the development of a global translational approach. Applicants will have complete freedom of research choice within the scope of blood cancers and will be offer highly attractive working conditions and a healthy, inspiring and creative working environment. CarrerasLeaders is designed based on the following objectives: 1. Training the next generation of scientist leaders to advance on the cure of blood cancers, multiplying each one’s skills sets and networks via targeted Career Development Plans and mentoring. 2. Improve the quality of blood cancers postdoctoral research training, more targeted addressed to the researchers and societal needs. 3. Enhanced cooperation and transfer knowledge between sectors and disciplines. 4. Enable outstanding junior researchers to develop their research careers to an advanced and more independent level in a leading institution such as IJC. 5. Increase the competitiveness of the IJC blood cancers community

Keywords: leukeamia,blood diseases,patients engagement,international,postdoctoral researcher,scientific skills,transferable skills,leadership,mobility,international,basic and translational research