Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Nanoformulation of Antimicrobial Peptides to Treat Bacterial Infectious Diseases (FORMAMP)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Sweden,Sweden,Sweden,Germany,Netherlands,Sweden,France,Denmark
Call:  (FP7-NMP-2013-LARGE-7, 2013)
Start date: 2013-12-01
End date: 2017-11-30
Duration (months): 48.0
Total project cost (EUR): 10348954.9
EU funding (EUR): 7945494.0
Participants: 16
Project status: CLOSED

Resistance to traditional antibiotics is a rapidly increasing problem that in a few years could make infections impossible to treat and bring the state of medical care back to the pre-antibiotic era from the beginning of the last century. Antimicrobial peptides (AMPs) have a huge potential as new therapeutics against infectious diseases as they are less prone to induce resistance due to their fast and non-specific mechanism of action. The aim of FORMAMP is to explore a number of innovative formulation and delivery strategies based on nanotechnology in order to improve the efficiency and stability of AMPs in clinical development. Functional delivery systems that can be applied directly on the infected site will be developed for treatment of infections in skin and burn wounds, as well as lung infections caused by Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Mycobacterium tuberculosis (MTB). Formulation and delivery strategies to prevent and treat biofilm formation related to these conditions will be developed. Different nanoformulation platforms, particularly promising for peptide delivery, controlled release strategies and technologies against proteolytic degradation of peptides will be evaluated in the project. These include lipid-based systems such as lipidic nanocapsules, polymer-based structures such as dendrimers and microgels as well as nanostructured mesoporous silica. The possibility to formulate the nanostructured materials into efficient drug delivery systems such as a topical spray or gel and pulmonary aerosol will be evaluated. The effect of nanoformulated AMPs will be evaluated with state-of-the art in vitro models and in vivo models. The results of this interdisciplinary project will generate efficient treatment strategies combatting one of the largest threats to our health care system today, reducing healthcare costs and expand the growth of European enterprises within the field of pharmaceutics and nanomaterials.

Keywords: antimicrobial peptides,biofilms,dendrimers,drug delivery,infections,lipids,nanoformulation,nanoparticles,multiresistant bacteria,polymers,pulmonary,skin infections,topical,tuberculosis
REFFIBRE - Tools for Resource-EFficient use of recycled FIBRE materials (REFFIBRE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Finland,Germany,Germany,Spain,Netherlands,Belgium,Romania,Spain,Switzerland,Sweden
Call:  (FP7-NMP-2013-SMALL-7, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 3937100.14
EU funding (EUR): 2785782.0
Participants: 11
Project status: CLOSED

As a result of the shift towards a bio-based economy, the demand of fibres from previously non-forest sectors (such as the energy sector) has increased. This has had a significant impact on the paper and board industry and the prices and demand of the recycled fibre based raw materials have started to increase. The pulp and paper industry has to improve the resource efficiency of the current paper products with minimum environmental impacts. By-streams from recycling processes will in the future no longer be considered as (costly) waste streams but will be regarded as a source of many valuable components. They can be used for a production of additional high value products in addition to paper (multi-product mill concept). By optimising the use of different material fractions with lower papermaking potential from recycling streams, both material and energy savings of about 20 % each can be achieved for the same functionality of the paper and board products. Robust methodologies, models and tools are required in order to show the possibilities for resource efficient reuse and valorisation along the value chain. Production design and process modelling tools need to be linked together to determine the economic and technical feasibility of multi-product mill concepts as well as their environmental impacts. The experimental part includes the development of innovative analytical tools to control production processes, demonstrations and integration of the results to a practical guide for decision makers. The results will help complete value chains of paper and board industry, converting industry and end users to decrease their overall waste production, improve resource efficiency and increase competitiveness by value added novel products from waste with lower environmental impacts. Indicators relevant to resource-efficiency and environmental impacts are developed, tested in practical case studies together with the industry and used to further develop standards.

Keywords: resource efficient,energy consumption,environmental impacts,economic impacts,paper for recycling,recycled fibres,paper production,packaging material production,methodology,models,tools
Enhanced Energy Efficiency and Comfort by Smart Light Transmittance Control (EELICON)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Germany,Germany,France,Spain,Italy,Canada,Czechia,Sweden,Germany,Germany,Portugal,Germany,Slovenia
Call:  (FP7-NMP-2013-SME-7, 2013)
Start date: 2014-01-01
End date: 2017-06-30
Duration (months): 42.0
Total project cost (EUR): 7283482.76
EU funding (EUR): 5189381.72
Participants: 14
Project status: CLOSED

EELICON is concerned with an innovative switchable light transmittance technology developed previously in projects co-funded by the EU Framework Programmes. The core of this development are mechanically flexible and light-weight electrochromic (EC) film devices based on a conductive polymer nanocomposite technology with a unique property profile far beyond the current state-of-the art, opening the possibility to retrofit existing windows with a electrically dimmable plastic film. According to life cycle assessment studies, considerable energy savings may result when such films are included in appliance doors, automotive sunroofs, and architectural glazing, and the comfort is significantly enhanced. The development has been driven to the pilot-line production stage, however, the decisive step from research to innovation could not yet be accomplished for a number of technical and economic reasons. To overcome this gap, EELICON will tackle existing drawbacks by removing equipment limitations, automating processes, and establishing a high-throughput prototype production for a cost-effective high performance EC film technology in Europe. The ambitious goal will be approached by joining efforts of European and overseas players to integrate nanotechnology, materials, and production know-how, i.e., specific expertise of European SMEs. Relevant IP is available for exploitation. The project comprises a pilot-line, a validation, and a prototyping phase (incl. business planning) and fully complies with the objectives of NMP Activity 4.4 – Integration and call NMP.2013.4.0-3 - From research to innovation: Previously obtained research results are used by industry, the European paradox is relieved, valley of death is overcome by following three pillars of development eventually resulting in creation of new businesses in Europe. The project is characterised by strong industrial/SME participation. 8 out of 13 partners are industrials, 6 of which being SMEs with leading roles.

Keywords: electrochromic devices,light transmittance modulation,pilot-line production,prototyping,production research,process automation,system integration,technology transfer,printed electronics
Renewable source nanostructured precursors for carbon fibers (CARBOPREC)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: France,Germany,France,France,Germany,Germany,Spain,Russian Federation,United Kingdom,Italy,Italy,Hungary
Call:  (FP7-NMP-2013-LARGE-7, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 8582520.6
EU funding (EUR): 5968027.0
Participants: 15
Project status: CLOSED

More and more industrial sectors (e.g. automotive, wind energy, boatbuilding) are demanding lightweight and high-performance composite materials, which represent a strong driver to develop the carbon fibre (CF) industry. Today, almost 80% of CF available on the market are using PolyAcryloNitrile (PAN) as the starting raw material because of its superior properties compared to pitch based carbon fibres. However, CF produced from PAN are expensive which limit their application to premium industrial sectors looking for high-performance structural materials while accepting high material costs (e.g. aeronautics, military devices, and sport goods). The strategic objective of CARBOPREC is to develop low cost precursors from renewable materials widely available in Europe (lignin and cellulose) reinforced by carbon nanotube (CNT) to produce high performance CF for automotive and wind energy applications. To achieve this objective, two white fibre processes will be studied to produce continuous fibers: - wet spinning approach for the cellulose dissolved in phosphoric acid (H3PO4), - melt spinning by extrusion for the lignin. Moreover, the carbonization process as well as the different functionalisation steps will be deeply investigated to enhance significantly both, the carbonisation yield, and the added value brought by the developed carbon fibers in the final applications targeted. The CARBOPREC consortium led by ARKEMA gathers 14 partners coming from 6 different European countries and Russia. It covers the whole value chain needed to develop innovative carbon fibers from renewable materials.

Keywords: - carbon fibres - precursors - carbon nanotube - spinning processes - carbonization - lignin - cellulose
Reinforced Bioresorbable Biomaterials for Therapeutic Drug Eluting Stents (REBIOSTENT)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Ireland,Germany,United Kingdom,Italy,United Kingdom,Germany,Spain,Germany,United Kingdom,Germany,Germany
Call:  (FP7-NMP-2013-SME-7, 2013)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 5961711.6
EU funding (EUR): 4579131.0
Participants: 14
Project status: CLOSED

Active therapeutic biodegradable and biocompatible materials are highly in demand. These are required for the production of medicinal products in a variety of areas including implant technology, tissue engineering, drug delivery and wound healing. Within implant technology such biomaterials can be used for dental, bone and cardiovascular implants. Tailored mechanical properties, biocompatibility and degradation rate is the key to the development for a specific implant. Stents are tubular type implants that are deployed most commonly to recover the shape of narrowed arterial segments. Although, the clinical use of stents is widespread, they cause adverse responses including inflammation, in-stent restenosis and thrombosis. Endothelialisation of the stent greatly reduces these adverse reactions. In contrast to permanent stents there is great attraction in the notion of a biodegradable stent that recovers and maintains arterial shape and then gradually disappears and avoids further complications. In this multi-institution & disciplinary SME focussed project we will aim to provide the technological framework that leads to the production of reinforced polymeric biomaterials tailored towards stent manufacturing without adverse effects. Both natural and synthetic polymers will be produced and used. These will be reinforced and functionalised using a variety of techniques. Controlled delivery of suitable positive additives including antimitotic factors will be aimed for and their release monitored. These highly functionalised active biomaterials will be characterised thoroughly for material properties, biocompatibility, rate of biodegradation and used for the production of ideal stents. These will be characterized thoroughly leading to preclinical validation. All required production and manufacturing guidelines will be followed.

Keywords: biomaterials,biocompatible,biodegradable,resorbable,therapeutic,coronary artery stents,medical devices,implants
Rapid prototyping scaffolds for the nervous system (NEUROSCAFFOLDS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Italy,Italy,France,Sweden
Call:  (FP7-NMP-2013-EU-China, 2013)
Start date: 2013-07-01
End date: 2016-06-30
Duration (months): 36.0
Total project cost (EUR): 2321776.0
EU funding (EUR): 1799788.0
Participants: 5
Project status: CLOSED

Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives.

Keywords: scaffolds,cellular repair,neuronal networks
FAST industrialisation by CAtalysts Research and Development (FASTCARD)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Norway,France,Italy,United Kingdom,Russian Federation,Germany,Germany,Netherlands,Belgium,Netherlands,Netherlands,France,Spain
Call:  (FP7-NMP-2013-LARGE-7, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 11922930.2
EU funding (EUR): 8234108.0
Participants: 14
Project status: CLOSED

To meet short term European 20-20-20 objectives and long term targets of European Energy Roadmap 2050, an energy paradigm shift is needed for which biomass conversion into advanced biofuels is essential. This new deal has challenges in catalyst development which so far hinders implementation at industrial level: Firstly, biomass is much more complex and reactive than conventional feedstock; secondly development of such catalysts is traditionally done by lengthy empirical approaches. FASTCARD aims at: -Developing a novel "rational design" of nano-catalysts for better control; optimised based on advanced characterisation methods and systematic capture of knowledge by scalable mathematical and physical models, allowing prediction of performance in the context of bio-feedstocks; -Developing industrially relevant, insightful Downscaling methodologies to allow evaluation of the impact of diverse and variable bio-feedstocks on catalyst performance; -Addressing major challenges impacting on the efficiency and implementation of 4 key catalytic steps in biobased processes: • Hydrotreating (HT) and co-Fluid Catalytic Cracking forming the pyrolysis liquid value chain for near term implementation in existing refining units as a timely achievement of the 20-20-20 objectives: addressing challenges of selectivity and stability in HT; increased bio-oil content in co-FCC. • Hydrocarbon (HC) reforming and CO2 tolerant Fischer Tropsch (FT) forming the gasification value chain for longer term implementation in new European relevant infrastructure, representing 100% green sustainable route for Energy Roadmap 2050: addressing challenges of stability and resistance in HC reforming; stability and selectivity for FT. Advances in rational design of nano-catalysts will establish a fundamental platform that can be applied to other energy applications. The project will thus speed-up industrialisation of safer, greener, atom efficient, and stable catalysts, while improving the process efficiency.

Keywords: nano-catalysts,hydroprocessing,hydrocarbon reforming,fischer-tropsch,hydro-stabilisation,co-fluid catalytic cracking,top-down approach,advanced biofuels,rational design,micro-kinetic modeling
Pilot manufacturing line for production of highly innovative materials (PILOTMANU)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Italy,Spain,Germany,Poland,United Kingdom,Germany,Türkiye,Switzerland
Call:  (FP7-NMP-2013-SME-7, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 5354079.0
EU funding (EUR): 4014465.0
Participants: 10
Project status: CLOSED

The vision of PilotManu is the upscale of the current mechanical alloying technological facility into a powder manufacturing pilot line by further developing existing IPR-covered results owned by the SMEs in the consortium related to mechanical alloying technology and to innovative powder materials for different applications. The baseline technology that will be upscaled from a technological facility status into pilot scale, is the High Energy Ball Milling machine, able to deliver innovative materials for new product lines developed by SMEs and industrial partnership that will lead the technological upscale. The project will demonstrate the technological and economical viability of the pilot line by implementing advanced materials into coatings, abrasive tool and additive manufacturing applications. Additional application sectors will be represented in the business cases by analyzing the cost/benefits of using the following new materials: Mg hydrides for hydrogen storage, thermoelectrics for energy harvesting, flame retardant textile and polymer nanocomposite for rapid prototyping. The potential impact brought by the new HEBM pilot production will be transversal also in all those technological sectors demanding high performance and outstanding material properties not achievable by conventional products. These huge un-exploited knowledge reservoir related to materials produced via HEBM or Mechanical Alloying will be unlocked by the Pilot Manu production system able to bring these results into the market.

Keywords: pilot line,mechanical alloying,thermal spray,cold gas spray,additive manufacturing,abrasive tools,advanced materials,spark plasma sintering
Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries (GUIDENANO)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Spain,Spain,Germany,Sweden,Italy,Czechia,Czechia,Italy,France,Sweden,Portugal,United Kingdom,Netherlands,Spain,Netherlands,Finland,Sweden,United Kingdom,Spain,United Kingdom,France,Spain,Netherlands,Netherlands,United Kingdom
Call:  (FP7-NMP-2013-LARGE-7, 2013)
Start date: 2013-11-01
End date: 2017-04-30
Duration (months): 42.0
Total project cost (EUR): 11143363.61
EU funding (EUR): 8150000.0
Participants: 33
Project status: CLOSED

The main objective of GUIDEnano is to develop innovative methodologies to evaluate and manage human and environmental health risks of nano-enabled products, considering the whole product life cycle. A strategy to identify hot spots for release of nanomaterials (NMs) will be followed by decision trees to guide on the use of (computational) exposure models and, when necessary, design of cost-effective strategies for experimental exposure assessment. These will include on-site and off-site monitoring of industrial processes, use, accelerated aging, recycling and disposal set-ups. In all cases, there will be a strong emphasis on the transformation of NMs. Similarly, a tiered strategy to evaluate the environmental fate and the hazards for ecosystem and human health of NMs will be developed. The project will consider pristine synthesized NMs, transformed NMs released during the life cycle of the product, and interactions of the NMs with other substances in their host matrices and ubiquitous pollutants. The project will also develop innovative solutions to reduce identified risks. These will include safer-by-design approaches (to reduce NM hazard, reduce migration and release, or accelerate degradation when released), new technological solutions for exposure control measures, and solutions for waste minimization and treatment. These developments will be incorporated into an web-based Guidance Tool, which will guide the nano-enabled product developers (industry) into the design and application of the most appropriate risk assessment & mitigation strategy for a specific product. The correct implementation of this guidance will ensure that the risks associated to a nano-enabled product, throughout its whole life cycle, have been appropriately evaluated and mitigated to an acceptable level. This methodology will set up the basis for the certification (by an independent third party), as a risk communication tool addressed to regulators, insurance companies, and the society.

Keywords: safety,nano-enabled product,life cycle,fate,workers,consumers,ecosystems