Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of genome regulation in the origin of animals (PREMETAZOAEPIGENOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The goal of this proposal is to understand how animals emerged from their unicellular ancestors. It is clear that the role of the genome regulation at the level of chromatin organization plays a crucial role in cell type specification, a hallmark of animals. However, how these genome regulatory mechanisms arose and whether they were already present in the unicellular ancestor of animals remains an open question. So far, there is minimal information to address this question from a comparative point of view. To fill this gap, we will characterize histone modifications, DNA methylation and open chromatin regions in one of the closest unicellular relatives of animals, an ichthyosporean Creolimax fragrantissima, which exhibits a multicellular-like developmental cycle. In particular, we will carry out a comprehensive genome-wide analysis of histone modifications by ChIP-Seq, ATAC-Seq, as well as techniques for detecting the distribution of 6-methyladenosine DNA marks, during the developmental cycle. In parallel, we will also investigate the Myc transcription factor network. Myc, along with its partners Max and Mad have been discovered in unicellular holozoans, suggesting that the network has already regulated cell proliferation and differentiation in the unicellular ancestor of animals. We will detect the genomic targets of Myc, Max and Mad proteins by performing ChIP-Seq. To complement these results with functional studies, we will develop genome editing tools in Creolimax. The data and the comparative analyses will provide significant insights into the nature of the regulatory genome of the last unicellular ancestor of animals. Specifically, we will learn whether the last unicellular ancestor already possessed features of complex genome regulation, such as distal enhancers, gene silencing, and dynamic regulation of chromatin states during development, and to what extent the complexity and function of the Myc transcription factor network was already present.

Keywords: origin of animal multicellularity
Investigation of shape evolution in neutron-rich nuclei using gamma-ray spectroscopy techniques (Shape Evolution)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

In the past 100 years, various theoretical approaches have been proposed to model the complex strong interaction between the neutrons and protons in a nucleus, however, a thorough understanding of its quantum structure is still far from being complete. Studies of the evolution of nuclear structure in mass regions away from the valley of stability have revealed dramatic modifications of the ordering of single-particle orbitals in exotic nuclei as compared to the ones predicted by the Shell Model. These surprising results have prompted the need for a detailed study of exotic nuclear systems in order to identify the driving forces behind them. The experimental study of these highly unstable exotic nuclear systems is extremely challenging and have become possible only recently due to the advent of radioactive ion beam facilities and highly efficient detection systems. This research project proposes to study neutron rich exotic nuclei in mass A~100-110 region though gamma-ray spectroscopy using fusion-fission and Coulomb excitation experiments. The experiments will measure the lifetime and static quadrupole moments in these nuclei, which will allow a determination of the shape and deformation of the nucleus. The results of these measurements will allow for a stringent test of various nuclear structure models. A study of shape evolution in these nuclei may also help in understanding the residual interactions responsible for changing shell structure in neutron rich nuclei. The experienced researcher will acquire new knowledge and training in nuclear structure physics and in innovative instrumentation, complementing her current expertise. She will learn about various aspects of experiment with radioactive ion beams and new data analysis techniques. She will also get the opportunity to improve her abilities in communicating scientific information to the scientific community as well as to the wider public.

Keywords: nuclear structure,coulomb excitation,lifetime measurement,gamma ray spectroscopy
Contexts of and Relations between Early Writing Systems (CREWS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-09-30
Duration (months): 78.0
Total project cost (EUR): 1472519.0
EU funding (EUR): 1472519.0
Participants: 1
Project status: CLOSED

Contexts of and Relations between Early Writing Systems This project takes an innovative and interdisciplinary approach to the history of writing, redressing lingering problems that have hampered previous research and developing new methodologies for studying scripts and their social context. The staff on the project will work on specific case studies relating to inscriptions of the ancient Aegean, Eastern Mediterranean and Levant (c.2000-600 BC), developing a new and much deeper understanding of writing, literacy and social and cultural interrelations in the area than has ever been possible via the often out-dated traditional methods usually applied to these data. The focus will be on enriching our understanding of both linguistic and social aspects of the borrowing and propagation of writing. This planned research has the potential to change the way we think about writing systems, their societal context and the ways in which ideas were exchanged in early civilisations. Published and publicised through multiple outputs and media, the results will be of importance not only to the specific chronological period and geographical area under close consideration but also to the diachronic study of relationships between population groups and the significance of such relationships for the wider field of cultural history.

Keywords: history of writing,epigraphy,social context of writing
MOdelling Vocal Expression in Schizophrenia (MOVES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

The human voice is a powerful tool for social communication. In recent years, Artificial Intelligence (AI) fostered the development of advanced voice systems, able to infer considerable information from the speaker’s voice, such as emotional and mental states, mood information and personality traits. Individuals with schizophrenia (SZ) tend to present voice atypicalities, which are related to core clinical symptoms and social impairment. Recent advances in voice technology may lead the way to a revolution in the study of voice disorders. They may allow to disentangle the affective, cognitive and social mechanisms responsible for voice atypicalities, assist clinicians in diagnosis and monitoring of the disorders, and enhance their capability to capture the complex relationship between vocal behaviour, emotion regulation and clinical features. However, our present understanding of voice abnormalities in SZ is very poor, limited by the lack of comprehensive models and systematic approaches to study voice production. MOVES aims at providing a solid understanding of the implications of atypical voice patterns in SZ: through the application of machine learning and signal processing technologies (AI), I will provide a first comprehensive account of the mechanisms underlying voice atypicalities, assess their impact on clinical evaluations, and create the foundations for more reliable and evidence-based screening tools. The project aims to foster multi-centric and international collaborations to overcome important limits of this research field, such as the need for cross-linguistic studies, larger datasets, and open and collaborative research. MOVES pioneers a new area of research at the intersection between cognitive neuroscience, psychiatry, computational science and AI. An innovative aspect of the project is the intention to translate recent AI technological advances into clinical settings, to improve the way we conceptualise, assess and monitor voice disorders in SZ.
CONductive fast Charge system for Electric buses in Public Transport (CONCEPT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2015-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heliox, a company specialized in switch mode power technology, is developing a Conductive Fast Charge System for buses which will offer a cost-effective breakthrough technology for zero emission public transport AND competitive strength to the European Bus manufacturing industry. Heliox' Conductive Fast Charge System is designed for opportunity charging at e.g. end of bus line, extending the range of an (H)EV. A minimal onboard energy storage, enough to reach the next charging station, becomes practically sufficient to optimally operate a vehicle with low TCO and high availability. Potential userds are: Potnetial users are public transport operators and European bus manufacturers. The objective of this feasibility study is to further verify the technological /practical as well as economical viability of the product. The 6 months of Phase 1 will be used to develop a detailed business plan, strengthen the relationship with potential customers and partners and define the technology. Heliox intend to submit a Phase 2 appliciation after finishing Phase 1.

Keywords: zero emission public transport,electric vehicle,conductive fast charge system
SolarGaps – Energy generating smart solar window blinds (SolarGaps)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ukraine
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2021-10-31
Duration (months): 29.0
Total project cost (EUR): 1422763.75
EU funding (EUR): 995934.63
Participants: 1
Project status: CLOSED

SolarGaps smart solar blinds is world’s first solution allowing most of the households and commercial buildings to easily utilize window area for efficient green energy generation thus decreasing electricity bill and CO2 emissions. According to the European Parliament buildings today are responsible for 36% of energy consumption and CO2 emissions in Europe, and so Directive on the energy performance of buildings requires all new buildings to be near zero-energy consumption from 2020 onwards. However, the old buildings refurbishment remains the main challenge. From the consumer perspective, increasing electricity prices create a challenge for both households and business budgets. Therefore, private solar photovoltaic electricity becomes very popular in developed market as its price decreases, but there is no efficient solution for those without sufficient roof or land area. On other hand smart shading solutions are also in demand as they not only increase life quality and working efficiency but can also contribute to buildings' energy efficiency decreasing electricity bill. However, on the existing market there is a lack of affordable, easily compatible exterior smart home and smart office shading solutions. SolarGaps creates unique value by executing two functions simultaneously: saving up to 30% of electricity bill (as a shading and a solar energy generation device), while enhancing life quality for B2C clients and creating pleasant working environment for B2B customers. Currently, SolarGaps has fully functional B2C product and is collecting feedback. Thus, objective of the Phase 2 project is to complete the technological and commercial development of the powerful B2B smart solar blinds system, set-up and test pilot production infrastructure, validate the SolarGaps smart solar blinds performance during the piloting with B2B customer and bring the product to the market based on the commercialisation plan developed during the Phase 1 project of SME Instrument.

Keywords: smart solar blinds,smart shading,solar pv electricity,smart home,smart office,solar energy,generation,energy efficiency,smart energy management,co2 reduction,energy savings,cooling,savings
THERVACB: A THERAPEUTIC VACCINE TO CURE HEPATITIS B (TherVacB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Germany,Spain,Germany,Tanzania, United Republic of,France,United Kingdom,United Kingdom
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 10425686.25
EU funding (EUR): 10425686.25
Participants: 18
Project status: SIGNED

Experts in virology, immunology and clinical hepatitis B patient care with an excellent research and translational track record in hepatitis B virus (HBV)-host interaction form the interdisciplinary TherVacB consortium. They jointly tackle the major challenges in HBV therapy – the virus’s resistance to cure. TherVacB aims at breaking immune tolerance in chronic HBV infection and achieving HBV cure. Occurrence of neutralizing antibodies and HBV-specific T cell responses characterize spontaneous resolution of HBV infection that are lacking in chronic infection. We will use our IP-protected heterologous prime-boost therapeutic vaccination scheme with proven efficacy in preclinical models of hepatitis B to target and activate B and T cell responses. Two protein prime injections with clinically approved, adjuvanted particulate HBV S and core protein antigens shall induce neutralizing antibodies and prime T cells that are boosted with an MVA vector expressing HBV core, S, L and polymerase antigens covering >95% of HBV found worldwide. Having secured significant funding and partnerships to obtain GMP-produced vaccine components and to prepare a first-in-human application, TherVacB aims at a clinical proof-of-concept of the therapeutic hepatitis B vaccine in patients with chronic hepatitis B. The consortium will establish a patient registry and perform a multi-center phase Ib/IIa clinical trial that aims at proving safety of the therapeutic vaccine and inducing immune control of chronic HBV infection. One study arm will be realized in Tanzania to build up local capacity, because Africa carries a large burden of HBV infection but lacks diagnostic and therapeutic options. An innovative immune monitoring will quantify HBV-specific immunity and define novel biomarkers to predict treatment response. Finally an ethical and an empirical study will evaluate the recruitment of patients by social media which is very effective for infectious diseases that tend to stigmatize patients

Keywords: viral hepatitis,hbv cure,hepatitis b,patient stratification,patient cohorts,clinical trial,therapeutic vaccine,adjuvant,patient recruitment,capacity building africa
Fun, Healthy and Safe Finger Food for Babies and Children (FEALFI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In 2010, 1 in 3 European children aged between 6-9 years old were overweight or obese – increasing from 1 in 4 ratio by 2008. Obese and overweight children are more likely to grow obese or overweight adults. It is estimated that obesity has about 7% impact in the national health budgets, across the EU. Childhood is an important time to instil a preference for healthy behaviours. We have developed the first vegetable-based finger food for babies and children. Made of organic vegetables cooked below 100 °C, with no additives, no added sugar and no allergens, our product is as good as homemade food. Vegetable-based finger foods for babies and young children have several advantages: i) helps developing healthy taste habits – parents often struggle with babies and children to eat their vegetables; ii) babies and children can grab it with their hands, which is fun, promotes autonomy and develops motor skills; iii) it replaces junk food and can be served as a meal or as a snack. We target parents who are often too busy to prepare a special meal for their babies or children. In general, these parents are rather urban and active searching for practicability and time saving. We expect to have a major impact for parents who have babies or children with special diet requirements due to health issues, such as overweight, diabetes or food allergies. The baby food market was valued at €43bn in 2017, from which €8.6bn correspond to prepared baby food. The organic baby food market represents about 15% of the total baby food market and is projected to grow with a 12 % CAGR forecasted in 2017-2025. We are aiming to start scale up of our technology in 2019, targeting €16m in revenues by 2022 with 23+ FTEs. In this Phase 1 project we will investigate the new target market segments & develop a strategy to scale.

Keywords: baby food,organic food
Reinventing a smart, circular and competitive textile industry with advanced myco-fibres (MY-FI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Italy,Germany,Italy,Germany,Italy,Belgium,France,France,Netherlands,Netherlands
Call: Innovative textiles – reinventing fashion (H2020-FNR-2020-1, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 6538922.78
EU funding (EUR): 5402393.0
Participants: 16
Project status: SIGNED

The aim of MY-FI is to provide the textile industry with a new nonwoven fabrics made of mycelium fibres, with improved performances and reduced environmental impact in comparison with current commercially available fibres. Mycelium fibres are obtained by fungal fermentation, starting from the residues of the textile indusrty, using a mild process and can be used to produce sustainable and performing nonwoven fabrics. Mycelium fibres indeed can extend the field of use of nonwoven fabrics to demanding or luxury applications. In virtue of their properties and aesthetics, mycelium fibres can be adopted, for example, in automotive or footwear applications that currently use animal leather as preferred material. In MY-FI new biofabrication protocols will be optimized and upscaled together with wet processing and material finishing to provide a set of innovative solutions to help the textile industry in facing the challenges posed by the complex megatrends that are quickly chagning markets and customers' lifestyles globally. The mission of MY-FI is to develop a biobased textile, with advanced functionalities, sustainability and performance, achieving four high level goals: 1. empowering the textile industry to successfully face the challenges posed by the emerging global trends; 2. meet the consumer demand for new functional and sustainable textile products; 3. relief the environmental pressure related to the textile industry, developing a circular and biobased textile that does not generate microplastics. 4. engage the textile stakeholders and provide guidance to policymakers Mycelium fabrics indeed are fully biobased and sustainable, obtained from circular value chains, widely customizable, highly performing, and can be produced using advanced manufacturing process. Thanks to these properties they have the potential to meet the market demands for sustainable and performing materials, allowing designers and brands to create more functional products.

Keywords: fungal fermentation,mycelium,circular economy,biobased textiles