Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and Neurostimulation (AEGEUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Italy,Iceland,Austria
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2998988.75
EU funding (EUR): 2998988.75
Participants: 8
Project status: SIGNED

The overall goal of this project is to develop a radically new diagnostic and therapeutic device for neurological applications which combines a highly innovative ultrasound component for brain imaging and focused stimulation of brain regions with advanced electrophysiological measurements of neural activity. First goal of the project is the development of a novel ultrasound (US)-based functional imaging method that, in conjunction with electroencephalography (EEG), allows for high spatiotemporal resolution examination of brain activity. While EEG itself yields best data from neural tissue close to the skull, the US component is designed to deliver images from deeper brain regions. The second pillar of the device’s function is focused US brain stimulation. Based on the possibility to localize abnormal activity, the neuromodulation component of the novel device can be guided to focal stimulation of selected brain regions, which can be further developed into a closed-loop design. The full envisioned system is a versatile tool that combines EEG-sensors and US transceivers in a wearable headset. The project foresees the development of hard- and software as well as algorithms to integrate the information from both modalities into functional neuroimaging with unpreceded spatiotemporal resolution. Beyond the technical realization, this project includes a proof of concept study to evaluate and demonstrate practical applicability in healthy participants and in patients with epilepsy, during clinical routine examination, cognitive, and sensory stimulation, including test-retest validation. The new device will reduce the time to examine and treat neurological patients and the cost thereof. The ability to perform better diagnosis via accurate imaging, targeted neurostimulation, and neuromodulation with a cost-effective, non-invasive device will have transformative effects on treatment options for neurological diseases and stimulate new lines of research in cognitive neuroscience

Keywords: ultrasound,eeg,imaging,stimulation,proof of concept
A proprietary scalable skin engineering platform (PELAGEN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Leather production sits atop the livestock agriculture that accounts for 18% of all global greenhouse gases emissions, uses 50% of the world’s water supply, 30% of the Earth’s landmass. 1Bn animals are slaughtered worldwide for the leather trade every year. The leather substitutions fail to provide expected quality of natural leather. Their plastic-dependent production is unsustainable provoking health issues, microplastic and chemical water, and soil pollution. We at PELAGEN leverage decades of groundbreaking research from Leiden University Medical Center, global leader in skin engineering, to bring to the market next generation natural leather without negative environmental impacts, or impacts on animal welfare. Our first product is cow and sheep leather (representing 65% and 15% of the animal leather market respectively). We have obtained, for the first time in the industry, a full-grain skin, and successfully tanned it into leather. We have validated this Minimal Viable Product with the industry (Hermes, Chanel, Kering, LVMH, Secrid, Mercedes Benz, Pangaia). They are ready to engage but wait for our production capacity to match their demand. Fabricating our product at scale will allow producing high-quality natural materials with 99% lower land footprint; 100% lower agricultural contamination; 90% lower GHG emissions; 90% lower tanning chemical usage; 50% less waste; zero slaughter, compared to conventional leather production. We have a transdisciplinary team with expertise in genetics, biology, skin engineering, scale-up, bioprocess automation and mechatronics. We are advised by internationally recognized experts in VC, M&A, scale-up, advanced materials, bioprocess engineering, biotechnology, and sustainable purchasing in the fashion industry. We have raised €2M of dilutive and non-dilutive funding. The EIC support will advance our efforts in acquiring higher quality product, moving towards industrial scale-up, accelerating the expansion of our platform.

Keywords: bioproduction platform,biofabrication,skin engineering,tissue engineering,lab grown leather,full grain
SUstainable self-charging power systems developed by INKjet printing (SUINK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Belgium,France,Finland,Spain,Italy,Lithuania
Call: Functional electronics for green and circular economy (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4966017.5
EU funding (EUR): 4966017.5
Participants: 13
Project status: SIGNED

Industry demands to reduce the weight of components in order to increase productivity and energy efficiency have led to the development of embedded functional electronics solutions to reduce the weight and volume of smart products. The Sustainable Development Goals balance the three dimensions of sustainable development (economic, social and environmental). SUINK will focus its developments on meeting sustainability indicators along the entire value chain (design, manufacturing, use and end-of-life) The main objective of SUINK is to design and implement sustainable, flexible and printable self-charging power systems (SCPS) able to supply power to a wide range of sensors. This SCPS will be formed by sustainable elements: 1) a piezoelectric energy generator to harvest electrical energy from mechanical vibrations based on pìezoelectric PLA, 2) a rectifying system as a connection circuit with 3) a fully printed biobased supercapacitor as energy storage component. The overall solution will be based on the proper combination of biobased conductive, dielectric and piezoelectric inks that will be applied by inkjet printing, a high throughput and easy-to-implement process, on biobased flexible substrates. The printed substrates will be implemented in the following elements: 1) a PLA seat (temperature sensor), 2) a PLA bracket located inside the car, specifically in the windscreen of the car (temperature/humidity sensor) and 3) a thermoset composite (strain sensor). The foils will be used for the creation of in-mold structural electronics through a) plastic injection over moulding; b) one-shot hybrid textile and c) autoclave/sheet moulding processes, towards the development of multifunctional components meeting the requirements of the automotive. SUINK will consider not only the sustainability during the design, manufacturing and use, but also will promote the circularity at the products end of life implementing new recyclability and reusability protocols for thDFAW EW RWE

Keywords: ink jet,printable,inks,piezoelectric,supercapactitor,biobased,recyclability,energy
Achieving animate properties with nonlinear odd solids (ANIMODD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

How can we create animate synthetic materials, able to sense, compute, and respond to their environment? To achieve these animate properties, one emerging class of materials stands out: odd solids. Odd solids use microscopic energy injection to break basic symmetries like Newton’s 3rd law, resulting in far-from-equilibrium phenomena forbidden in passive materials. These phenomena promise a toolkit for designing animate functionalities like robust locomotion and pattern formation. However, to realise animate properties odd solids face a fundamental challenge: microscopic energy injection inherently leads to nonlinear mechanical deformations, yet this nonlinear regime remains completely unexplored. In this proposal I will surpass this limitation, by characterising the nonlinear excitations of an odd solid, then using these excitations as a toolkit for designing animate properties. Using continuum mechanical theory and lattice simulations, I will derive new fundamental results on travelling patterns and topological defects in odd solids, and determine how these nonlinear excitations interact with environmental cues like substrate friction. Crucially, I will then use these excitation-environment interactions to realise animate properties in a ready-made table-top experimental system. This proposal marries my expertise in nonlinear excitations in active systems, with the host’s expertise in the experimental development of odd solids, to push our fundamental understanding of odd interactions beyond the linear regime. My results will open a new line of research in active matter and animate materials, applicable across systems in which odd interactions can be designed – from robotic matter, to living systems, down to the microscale. By positioning me at the heart of the emerging field of animate matter, and equipping me with a powerful new skillset of experimental experience and techniques, this Marie Curie action will take my scientific career to the next level.

Keywords: odd elasticity,nonreciprocity,active solids,active matter,mechanical metamaterials
Parallel De Novo Design and Screening of multiple site-specific Cell-Permeable β-Hairpin-based Inhibitors (PBhI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

The primary goal of this project is to integrate advanced techniques for the generation of Permeable β-hairpin-derived Inhibitors (PβhdI) of intracellular targets. Specifically, the approach will combine site recognition and epitope discovery from de novo design with enhanced affinity achieved through phage-display maturation. Additionally, it will improve stability and permeability via interstrand crosslinking (e.g., using bis-electrophiles or disulfides), which will also facilitate phage library diversification. By using these techniques synergistically, the project aims to significantly advance the design of intracellular drugs, potentially broadening the range of available therapeutic options and enhancing the efficacy of targeted treatments. The methodology focuses on the large-scale design and characterization of cell-PβhdI that target multiple binding sites on an intracellular therapeutic target, such as β-catenin. β-Catenin, a key component of the Wnt signaling pathway, is an attractive intracellular target due to its role in various cancers driven by aberrant Wnt signaling. The heterovalent nature of β-catenin, which possesses four distinct binding sites and well-characterized crystal structures, provides an ideal framework for assessing the effectiveness of multiple site-specific binders. Those, combined with the host institution's expertise in studying this oncogene, makes β-catenin an ideal candidate for applying and refining this new methodology.

Keywords: hairpin,intracellular targets,de novo design,high throughput,crosslinking
Sub-chromosomal regulation of mitotic transcription inhibition (SUB-SCRIPT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: SIGNED

Chromosome condensation during mitosis has long been assumed to render mitotic chromatin incompatible with transcription. However, recent evidence shows that some chromosomal regions (e.g. centromeres, some genes) are transcribed in mitosis. These findings imply that mitotic transcription inhibition (MTI) is not a global event along the entire chromosome. Instead, I propose that mitotic transcriptional silencing is spatially regulated, allowing specific loci to evade MTI and maintain their transcription. Testing this novel hypothesis is challenging due to our poor understanding of the mechanisms driving MTI. Additionally, commonly used techniques to study transcription (e.g. genome-wide approaches) provide snapshots of the process but lack temporal resolution to dissect fast changes in transcription. With SUB-SCRIPT, I will implement an advanced imaging tool in live cells to uncover the dynamics of ongoing transcription throughout mitosis, for selected loci. I will apply this approach to selected genes to test how transcription regulation in mitosis varies depending on gene architecture/identity. In parallel, I will make use of a putative MTI factor (my preliminary observations) to manipulate the transcriptional state of selected genes during mitosis. Both strategies will capitalize on my vast expertise in dCas9 use for chromosome targeting, which I will further exploit to imaging RNAs (dCas13). Ongoing work in the host lab on chromosome assembly and novel mechanisms that drive MTI provides an excellent environment for project implementation. The completion of this project will uncover how different genes display unique kinetics of transcriptional regulation during mitosis and how MTI is regulated at the sub-chromosomal level, challenging current views on how mitotic transcription shut-down occurs. It will also provide novel tools and concepts to explore how MTI can actively impact mitotic fidelity, transcriptional control, cell physiology and potentially disease.

Keywords: chromosomes,mitosis,cell cycle,transcription,dcas9
Enabling data analytics for actions tackling skills shortages & mismatch (TRAILS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Belgium,Ireland,Netherlands
Call: Tackling European skills and labour shortages (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2994403.75
EU funding (EUR): 2994403.75
Participants: 8
Project status: SIGNED

TRAILS proposes a holistic approach to identifying the conditions for skills gaps and shortages across European countries and to contributing to policy actions. Its approach involves all conceptual and theoretical models of optimal skills match and utilization by workplaces, new methodologies for measuring skill gaps, and understanding optimal ways to skills upskilling and reskilling. It involves novel primary datasets, state-of-the-art big datasets from administrative records matched to firms and workplaces, innovative inquiries with large secondary datasets that are merged with taxonomies and other sources to enable pathbreaking analyses, field and stated preference experiments, along with boost samples of groups of particular interest, such as platform workers and other stakeholders. All these elements will produce a canvas that enables a new framework for identifying the conditions and elements required for developing skills matched to the needs. It will allow the inspection of relevant behavioural, societal, and cultural dimensions affecting individuals' participation and choice of training and learning programmes. Moreover, the project will propose aims and objectives for basic and transferable skills that are most conducive to European labour mobility towards the green and digital jobs of the future. Finally, the project will propose ways to optimize the use of new technology-enhanced ways to bridge the gap between labour supply and demand in matching skills to needs. Via the usage of AI methods and the large-scale piloting, the project will propose ways that empower skills profiling and intelligence to raise awareness of training programmes matched to the needs of individuals and the jobs of the future for European labour markets. Ultimately, a TRAILS web-based tool will be developed to bring together new datasets and insights for policy makers and to raise citizens’ awareness regarding transferable skills and training programmes.

Keywords: new skills gaps indices,novel primary datasets,labour mobility,digital jobs,ai methods,transferable skills,fair transition,resilient workplaces
Simulation and Theory of Astrochemical Reactions on Surfaces (STARS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

Over 300 molecules have been identified in interstellar space, ranging from simple H2 to complex organic molecules such as ethanolamine. In the extreme conditions of interstellar space, gas-phase reactions alone cannot explain their formation, and ice-covered dust particles are believed to play a crucial role. However, little is known about the precise mechanisms of interaction between interstellar gas and icy dust particles, or how these ice surfaces might "catalyze" the necessary chemical reactions. In particular, the effect of charge remains poorly understood. The STARS project aims to establish a new framework to investigate these interactions on both neutral and charged ice particles using state-of-the-art computational techniques. I will construct representative ice structures, calculate binding energies of astrochemically relevant molecules, and compute free energy profiles and rate coefficients for a paradigmatic set of reactions. In collaboration with leading experts in the field, I will also assess the impact of these interactions on resulting gas-phase abundances, enabling accurate benchmarking against experimental data. This interdisciplinary project bridges astrochemistry and surface science, with the potential to deepen our understanding of how interstellar icy dust particles drive the chemical evolution of the universe. To achieve the objectives of the STARS project, I will conduct my research at the University of Antwerp’s Chemistry Department under the supervision of Prof. Neyts, a leading expert in molecular simulations. This project will also strengthen my academic profile, preparing me for advanced funding opportunities and enabling me to establish my own research group.

Keywords: astrochemistry,molecular processes,computational chemistry
Quantitative multimodal pulse-and-label time-resolved chromatin maps (ChromaDYN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Chromatin packages the eukaryotic genome in a highly dynamic fashion, with dramatic structural changes during every cell cycle. At the same time, chromatin provides remarkable stability for transcriptional regulation and genome organization, for example in maintaining gene expression programs and lineage identity during complex organismal development. A mechanism to propagate information through ‘disruptive’ transitions in the cell cycle, namely DNA replication and mitosis, is key in maintaining heritable, so-called ‘epigenetic’ chromatin states. Proteins that build and interact with chromatin, foremost histones, are much more than static architectural components. This motivates the development of time-resolved quantitative assays in the living cell, which will allow to capture dynamic features of chromatin states over timescales from minutes to days. Building on a synthetic biology toolbox, a quantitative multimodal pulse-and-label strategy will be developed. Following protein populations in both time and subcellular/genomic space, dynamic protein-protein interaction networks and chromatin maps will be captured. The project will use to state-of-the-art quantitative biochemical, imaging, genomics and proteomics readouts, including single-cell readouts. These will feed into mathematical models to describe the dynamics and potential heterogeneity/stochasticity of the system under study, predict its response to perturbations and guide mechanistic hypotheses. The project will systematically decipher mechanisms for propagating epigenetic chromatin states, starting with the fundamental rules of histone inheritance through replication and mitosis. Additional levels of complexity introduced through chromatin remodeling activities, nucleosome turnover and histone exchange will be integrated. Finally, the dynamics underlying developmental chromatin state transitions, including asymmetric cell fate decisions, will be resolved.

Keywords: quantitative epigenomics,quantitative proteomics,chromatin dynamics,epigenetic inheritance,pluripotent stem cells,gene expression regulation,chromatin remodeling,mathematical modeling