Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enhancement of Memory- and Energy-related Properties of Fluorite Structured Ferroelectrics (MEFF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

For several decades, ferroelectric (FE) materials (particularly lead-based perovskite materials) attained wide attention for memory (non-volatile) and energy storage applications. The FE memories offer low power consumption, high speed, and high endurance and retention. However, the conventional FE materials couldn't surpass the niche applications due to the difficulties in scaling the size below the ~100 nm node. Recently, FE properties have been reported in doped HfO2 polycrystalline thin films. HfO2-based FE materials have several advantages over conventional materials, such as lead-free, compatibility with existing Si technology and CMOS, ultrathin thickness (in the range of nm), and suitability for integration within 3D nanostructures. Therefore, fluorite-structured materials can be appropriate for miniaturized devices. These materials are extensively studied for memory and energy-related applications. However, progress is still needed, such as more control in the microstructure of the films (formed phases and defects), understanding of complex switching behavior (including wake-up, fatigue, and split-up), and improvement of device reliability. This project investigates HfO2-based epitaxial films as a model system for energy storage and memory applications. We will focus on the enhancement of endurance without retention degradation of memory devices. This project also aims to enhance the energy storage properties of HfO2-based films. Moreover, we will also use artificial intelligence to analyze the relatability of memory and energy devices.

Keywords: hfo2,memories,ferroelectric,dielectric,energy stroage
Ultrafast control of magnetism with twisted plasmons (MagneticTWIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2048115.0
EU funding (EUR): 2048115.0
Participants: 1
Project status: SIGNED

Harnessing twisted light (light carrying orbital angular momentum) on the nanoscale, and its interaction with magnetism, can revolutionize how we encode and process information. In fact, twisted electromagnetic fields can enable a superior control over the motion of the electrons and their spin compared to circularly polarized light. Yet, a clear demonstration that it is possible to act on magnetism using twisted light has still to be established. The main challenge is to find an approach to generate nanoscale electromagnetic fields carrying orbital angular momentum, which can be exploited to drive magnetism with extreme (few nanometers) spatial resolution, at the intrinsic time scale (few tens of femtoseconds) of the fundamental magnetic interactions (exchange and spin-orbit coupling) responsible for the magnetic order in matter. This feature is essential for the development of ultrafast opto-magnetic applications in spintronics, where a major goal is the coherent control of nanoscale magnetic bits. In MagneticTWIST I tackle this challenge and propose the way towards nanoscale control of ultrafast magnetic phenomena by exploiting twisted plasmons, that is plasmon polaritons (light-induced coherent collective oscillations of free electrons in metals) carrying orbital angular momentum and driven by femtosecond light pulses. This strategy will enable a coherent transfer of orbital angular momentum to the electronic spin and orbital degrees of freedom at the nanoscale. In this way, I will disclose new types of light-matter interactions and new kinds of opto-magnetic effects, with a ground-breaking impact on ultrafast magnetism, spintronics and light-driven electronics. Beyond this, MagneticTWIST will open a radically new path enabling to store and process an infinite amount of information on different spatiotemporal levels, impacting also other research fields such as cryptography, artificial intelligence, and quantum technology.

Keywords: magnetoplasmonics,ultrafast plasmonics,magneto optics,ultrafast magnetism,angular momentum of light,opto magnetism,magnetization dynamics,exchange interaction,spin orbit coupling
Green innovation strategies for animal health management: towards sustainable Aquaculture (GRINNAQUA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Portugal,Spain,Norway,United Kingdom
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 1279170.0
EU funding (EUR): 1279170.0
Participants: 4
Project status: SIGNED

GRINNAQUA is conceived in compliance with the Farm to Fork Strategy and is focused in capacitating CIIMAR to raise staff’s research profile and increase its innovation capacity positioning the institution among the main actors in the area of aquaculture. Recognized leaders in R&D within European aquaculture with a solid background in relevant areas partnered with CIIMAR. Their profiles make these the ideal partners to push CIIMAR towards scientific excellence and competitiveness. INIA-CSIC (Spain) has significant expertise on the study of fish acquired immune system and vaccination strategies; Roslin Institute - Univ. Edinburg (UEDIN, UK) team has essential know-how in genetics and animal breeding; and Univ. Bergen (Norway) is proficient in the area of animal health and prophylactic strategies. Clear strategies are defined to raise staff´s research profile and excellence by implementing training workshops and Summer schools led by the partners. Several visits of CIIMAR´s staff to partners facilities are planned, targeting senior research, technical and administrative training, allowing the exchange of knowledge and good practices. The research project, integrating partners scientific and technical strengths, will in focus in the high economic impactful viral and parasitic outbreaks in aquaculture, studying the prophylactic effects of functional diets in rainbow trout against haemorrhagic septicaemia virus, and in Atlantic salmon infected sea lice parasite. This proposal outlines strategies to increase stakeholder interaction and its mobilization towards scientific achievements, strengthening CIIMAR’s market-driven research and innovation capacity to increase its competitivity at national and international levels. GRINNAQUA will be instrumental to improve CIIMAR innovation capacity to become a leading institute for the blue revolution in aquaculture. A long-lasting collaboration is foreseen, contributing to strengthen a more sustainable aquaculture in Europe.

Keywords: sustainable farming one health breeding strategies vaccination nutritional immunology
Magnesium and fetal metabolic programming: an approach to preventing a life-cycle of metabolic diseases (MagFetProg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Obesity prevalence is increasing as well as the related metabolic alterations. Obesity and T2D increase the risk of pregnancy complication and affect offspring health through developmental programming effects. Obese patients with T2D frequently present Mg2+ deficiency. During pregnancy, Mg2+ needs increases, and its insufficiency may affect the mother and fetus, interfering with pregnancy development and offspring growth. Although it is known the relevance of Mg2+, its role in pregnancy is often overlooked and the underlying mechanisms that causes disturbances on Mg2+ homeostasis are unelucidated. Mg2+ homeostasis is carefully regulated. Among the channels are the cyclin M 1-4 (CNNM1-4), highly conserved molecules. Although it has been suggested that Mg2+ transport and homeostasis plays a key role in development, its regulation during development and in maternal-fetal communication is not fully understood. Fetal growth is closely related to the placenta capacity to transport nutrients and ions. At birth, the fetus makes a transition from using placental nutrient supply to utilize the liver. Thus, changes in maternal liver metabolism related to Mg2+ levels and signalling could affect the maternal metabolic state and negatively impact the developing fetus. This project aims to assess the role of Mg2+ homeostasis and transport through the CNNMs in programming effects in the context of maternal T2D and obesity. We will focus on the role of Mg2+ on fetal programming effects in a context of altered maternal metabolism and to evaluate the impact on offspring liver. In addition, we will evaluate the potential dietary intervention with Mg2+ supplementation for ameliorating offspring-derived effects. We hypothesize that maternal obesity leads to an altered environment that involves an impaired maternal hepatic Mg2+ signaling through the CNNMs that affects the metabolic fetal environment and the maternal-fetal interaction and programs offspring metabolic alterations.

Keywords: endocrine,nutritional and metabolic disease,dohad,gene therapy
The Academia Secretorum Naturae : magic, secrets and instruments of experimental science in the sixteenth-century Naples (SECRETS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

This two-year EF will bring me at Ca' Foscari University of Venice (Italy), where I will be supervised by Prof. Marco Sgarbi. The overall aim of the project is to provide the first, complete historical-philosophical reconstruction of the Academia secretorum naturae, one of the earliest Societies in Europe, to explore in an innovative way the "secrets of nature", by performing experiments in the field of physico-chemical and mechanical sciences. The Academy was founded in Naples in 1560 by Giambattista Della Porta (1535-1615), one of the leading figures of the Italian Renaissance in natural philosophy, so much so, tha the echoes of his thought reached authors like Francis Bacon, Galileo, and Isaac Newton. The scientific activity of the Academy is able to be reconstructed by reading the "Magia Naturalis" by Della Porta. A study on the experimentalism promoted in Naples by the Academia secretorum naturae, which is at the core of the project, will significantly influence our understanding of the Italian Renaissance and its contribution to the so-called Scientific Revolution/rise of experimentalism. Research will aid in determining certain fundamental junctures between the shift from natural magic to the new science, clarifying the role of the peculiar empirical Aristotelianism, open to the instances of natural magic, mathematics, and practical knowledge, in vogue in the Naples of the 16th century; of the introduction of a clear codification of the experimental process of the secrets of nature, as of a readily identifiable scientific instrumentation introduced in Della Porta's Academy. The clarification of these two points will lead an understanding of how experimentalism, which developed in Italy during the Renaissance and spread throughout Europe thanks to the enormous popularity of "Magia naturalis", impacted the great European scientific academies of the 17th century.

Keywords: aristotelianism,natural magic,secrets of nature,renaissance philosophy,history of science and technologies
Next-Generation Quantum Key Distribution for a Secure Digital Future (NEXUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 3557373.76
EU funding (EUR): 2490161.63
Participants: 1
Project status: SIGNED

In an era of unprecedented digital threats, Europe faces a critical cybersecurity crisis. The coming of quantum computers threatens to render current cryptography methods obsolete, potentially exposing sensitive government, financial, & personal data to malicious actors. This is compounded by the “harvest now, decrypt later” strategy, where adversaries stockpile encrypted data for future decryption, jeopardizing long-term data security. Q*Bird addresses this crisis with our groundbreaking Measurement Device Independent Quantum Key Distribution (MDI-QKD) technology. Unlike traditional QKD systems, our solution offers unparalleled security, scalability, & cost-effectiveness. Our multi-point-to-multi-point architecture enables easy network expansion, dramatically reducing per-user costs while maintaining quantum-safe security. This innovation not only safeguards against current and future quantum threats but also lays the foundation for the emerging Quantum Internet. A European deep-tech startup, Q*Bird is uniquely positioned to contribute to the EU's technological sovereignty in this critical domain. Our technology aligns perfectly with key EU initiatives such as the European Quantum Communication Infrastructure (EuroQCI) and the Cybersecurity Strategy for the Digital Decade. However, the high-risk nature of quantum technology development, coupled with long commercialization timelines, creates significant challenges in securing sufficient private investment. EIC Accelerator support is crucial to bridge the gap between our current prototype and full commercialization. This support would not only accelerate our technology development but also catalyze additional private investment, enabling Europe to lead in the quantum communication revolution. With EIC backing, Q*Bird can transform the secure communications landscape, ensuring Europe's digital resilience in the quantum age.

Keywords: quantum cryptography quantum key distribution measurement device independent qkd cybersecurity quantum communication quantum networks quantum internet
A Novel ‘Radiotherapy from Within’ Platform Technology for the Targeted Treatment of Solid Tumours Called ‘BAT-90’ (BAT-90)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-04-01
End date: 2025-12-31
Duration (months): 21.0
Total project cost (EUR): 7135824.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

BetaGlue is developing an innovative "radiotherapy from within", personalized and cost-effective anti-tumoural platform technology called BAT-90. BAT-90 maximises the therapeutic index of loco-regional treatment by eliminating off-target radiation dose in a simple and easy to use product. The product aims to provide a radiotherapeutic treatment option for a range of solid tumour types including: unresectable hepatocellular carcinoma (HCC) and locally advanced and borderline resectable pancreatic cancer (PDAC) patients, where in the first-line setting, there exists a major unmet clinical need. Through the percutaneous administration of BAT-90 under radiological guidance (usually ultrasound) BAT-90 overcomes the accessibility and off-target side effect limitations of external beam radiotherapy, forms of brachytherapy, proton beam radiotherapy trans-arterial radio-embolisation and microwave ablation. BAT-90 has already demonstrated safety and preliminary effectiveness in first-in-human clinical studies.

Keywords: oncology radiotherapy hepatocellular carcinoma
The first minimally invasive curative solution for abdominal aorta aneurism (AneuFix)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

TripleMed's AneuFix represents a groundbreaking advancement in the field of endovascular aortic repair (EVAR). This innovative solution addresses the critical need for a long-term curative approach to treating abdominal aortic aneurysms (AAA), a condition that currently suffers from high reintervention rates (1 in 3 patients) due to endoleaks, stent migration and aneurysm sac expansion. AneuFix is the missing link capable of transforming the current gold-standard minimally invasive endovascular aortic repair (EVAR) technology into a long-term curative solution. This novel polymer-based solution fills the aneurysm sac during the EVAR procedure, fully occupying the sac to prevent endoleaks and reduce the need for reinterventions. By providing lifelong stability, AneuFix significantly improves patient outcomes. The method integrates seamlessly with existing EVAR workflows, utilizing standard guidewires and introducers commonly available in most hospitals. The current market for EVAR is plagued by high rates of reinterventions, primarily due to endoleaks. Surgeons and hospitals face significant costs and complexities associated with these repeat procedures. There is a growing shift in the medical community towards prophylactic treatments, and AneuFix is poised to meet this emerging demand with its innovative and effective solution. Our early trials have demonstrated the efficacy of AneuFix in over 35 patients, showing that it can effectively fill the aneurysm sac and make reinterventions a thing of the past. TripleMed employs a B2B business model, targeting hospitals and vascular surgeons for direct sales. Our commercialization efforts will be supported by a network of experienced distributors to ensure broad market reach. TripleMed's AneuFix stands out as a game-changing innovation in the EVAR market. AneuFix offers a simple yet revolutionary solution and is set to transform the landscape of aortic aneurysm treatment and improve patient care worldwide.

Keywords: endovascular aortic repair abdominal aortic aneurysms
Unraveling the potential of Quorum Sensing inter-species dialogue to restore microbiota’s community dynamics. (MicroDialogue)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal,Germany
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 2
Project status: SIGNED

The overuse of antibiotics has led to a disruption in gut microbiota, particularly in the Bacillota phylum, increasing susceptibility to pathogens, obesity, diabetes, and other metabolic disorders. MicroDialogue aims to evaluate the capacity of Quorum Sensing (QS) interspecies communication, a bacterial communication mechanism mediated by Autoinducer-2 (AI-2), to restore gut microbiota balance after antibiotic-induced perturbations and improve health outcomes. MicroDialogue will focus on the novel murine commensal non-pneumoniae Klebsiella sp. ARO112, which can provide colonization resistance against pathobionts, promote butyrate-producing bacteria, and produce AI-2, making it a promising candidate for promoting microbiota recovery. We hypothesize that manipulating AI-2 signaling with ARO112 can facilitate the recovery of the microbiota from antibiotic-induced dysbiosis. MicroDialuge’s main goal is to capitalize on the ability of ARO112, isolated by the host’s lab, to favor re-establishment of the Bacillota phylum while improving host immunity, via QS manipulation. To achieve this, we will manipulate the levels of AI-2 directly in the mouse gut using ARO112 WT and mutants already validated to assess the mechanistic effect of AI-2/ARO112 on axenic mice colonized with a defined microbiota. We will use metabolomics, and transcriptomics as part of a secondment at Jena University to reveal the molecular mechanisms involved in microbiota recovery. Additionally, we will test AI-2/ARO112-based therapies in mice colonized with a complex microbiota under antibiotic-induced dysbiosis. We will use CRISPR/Cas9 to modify ARO112 to track its colonization and flow cytometry to measure recovery of immune responses and inflammation. This research will expand our understanding of microbial QS and its potential to combat microbiota imbalances, with significant social and economic potential for human health by offering new strategies to mitigate the adverse effects of antibiotic use.

Keywords: quorum sensing,gut microbiota,bacterial signaling,gnotobiotic mice,bacterial transcriptomics,host physiology,molecular microbial ecology,innate immunity and inflammation,dysbiosis