Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MANAGING RESILIENT NEXUS SYSTEMS THROUGH PARTICIPATORY SYSTEMS DYNAMICS MODELLING (REXUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Italy,Spain,Spain,Spain,Greece,Romania,Colombia,Slovenia,Greece,Netherlands,United Kingdom
Call: Understanding climate-water-energy-food nexus and streamlining water-related policies (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 4984331.25
EU funding (EUR): 4984331.25
Participants: 19
Project status: SIGNED

REXUS ambitious goal is to bring transformative change in the way our societies approach the Water Food Energy Climate Nexus. The project argues that this is possible only through the activation of inclusive nexus partnerships, the Learning & Action Alliances (LAAs). The objective is for the pilot case Alliances in Europe and Latin America to develop shared visions and adaptive Nexus Management Strategies that will meet the Nexus sectoral objectives as well as broader criteria, such as habitat protection. In this context, LAAs will (a) co-produce new knowledge regarding Nexus interactions to inform the development of System Dynamics Models at suitable spatial and temporal scales and (b) explore multiple co-developed scenarios of demographic change, climate change, socio-environmental, economic incentivization and regulatory policies. Thus, SDM development is the means to (i) develop stakeholder platforms of trust, (ii) test the efficacy of integrated cross-sectoral policies, and (iii) build legitimacy for evidence-based decisions towards sustainable transitions. SDMs will inform climate risks assessments for combined-resource-management strategies by capturing the cascading effects among Nexus domains. The pilot cases will be the test-beds for the integration of methods, such as thematic biophysical modelling using Earth Observation, environmental cost valuations, natural capital and carbon accounting to explore case-specific challenges (including greening the CAP). In response to these challenges, Ecosystem-based Adaptation measures will be planned for these regional and transboundary systems. On a policy level, for the first time, REXUS will explore the opportunity to link Climate Adaptation (i.e. the Paris Agreement framework) to Nexus management as a means to push forward the Nexus agenda. The approaches above will support REXUS’ vision for Nexus systems that are managed within renewable natural resource constraints and in appreciation of climate feedbacks.

Keywords: climate adaptation,shared visions,stakeholder involvement,system dynamics,earth observation,climate risk assessments
Chromatin dynamics resolved by rapid protein labeling and bioorthogonal capture (RAPID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1846360.0
EU funding (EUR): 1846360.0
Participants: 1
Project status: CLOSED

Histone proteins provide a dynamic packaging system for the eukaryotic genome. Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division. For our understanding of cellular memory and epigenetic inheritance we need to know what features characterize a stable, heritable chromatin state throughout the cell cycle. State-of-the-art methods such as ChIP-Seq provide population-based snapshots of the epigenomic landscape but little information on the stability and relative importance of each studied feature or modification. This project pioneers a rapid, sensitive and selective protein labeling method (termed RAPID) for capturing genome-wide chromatin dynamics resolved over a period of time ranging from minutes to days. RAPID introduces a flexible time dimension in the form of pulse or pulse-chase experiments for studying genome-wide occupancy of a protein of interest by next-gen sequencing. It can also be coupled to other readouts such as mass spectrometry or microscopy. RAPID is uniquely suited for studying cell cycle-linked processes, by defining when and where stable ‘marks’ are set in chromatin. I will employ mouse embryonic stem cell (mESC) as a model system for pluripotency and lineage specification. RAPID will define fundamental rules for inheritance of histone and other chromatin-associated proteins and how they are modulated by the fast cell cycle of pluripotent cells. Using RAPID in combination with other state-of-the art genetics and epigenomics, I will collect multi-dimensional descriptions of the dynamic evolution and propagation of functionally relevant chromatin states, such as interstitial heterochromatin and developmentally regulated Polycomb domains.

Keywords: chromatin dynamics,cellular memory,cell cycle,bioorthogonal labeling,unnatural amino acid mutagenesis
Forensic Geneticists and the Transnational Exchange of DNA data in the EU: Engaging Science with Social Control, Citizenship and Democracy (EXCHANGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Portugal,Portugal
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1838150.0
EU funding (EUR): 1352147.88
Participants: 2
Project status: CLOSED

Today we are living in the “genetic age” of criminal investigation. There is a widespread cultural belief that DNA technology has the unrivalled capacity to identify authors of crimes. In light of this ideology, EU Law (Prüm Decision, 2008) obliges all Member States to create the conditions for the reciprocal automated searching and comparison of information on DNA data for the purpose of combating cross-border crime, terrorism and illegal immigration. Forensic geneticists play a crucial role in this scenario: they develop the techno-scientific procedures that enable DNA data to be shared across national boundaries. EXCHANGE aims to understand the close links between a highly specialised field of expert knowledge – forensic genetics – and surveillance in the EU. If the EU succeeds in this political project, about 10 million genetic profiles of identified individuals will be exchanged between agencies in all EU countries. This raises acute cultural, political and societal challenges. EXCHANGE aims to address these challenges by scrutinizing how forensic geneticists, within the context of the transnational exchange of DNA data in the EU, engage with the social values attributed to science – i.e. objectivity, truth – and the values of social control, citizenship and democracy. The expected outputs are: 1. To provide a general picture of the Prüm framework by conducting interviews with forensic geneticists in all EU countries; 2. To develop in-depth knowledge of forensic geneticists’ activities relating to Prüm using ethnographic observation and qualitative analysis of criminal cases; 3. To study countries with different local positionings in relation to Prüm by means of a comparative study involving Portugal, Germany, the Netherlands and the UK. EXCHANGE stimulates interdisciplinary dialogue between the social sciences and the forensic genetics. This research also tackles questions that are relevant to all the actors involved in criminal justice cooperation in the EU.

Keywords: social studies of forensic genetics,dna evidence,transnational exchange of dna data,surveillance,suspects,social control,citizenship and human rights,democracy,pr m decision
ProZero - carbon based fast boats for professional use (ProZero)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 2574553.75
EU funding (EUR): 1802187.63
Participants: 1
Project status: CLOSED

Tuco Yacht Værft ApS (TUCO) aims to pursue a major market opportunity by developing and commercializing carbon fibre fast boats for professional use based on a flexible and simple production platform. Carbon excels from the other materials, especially due to the highest strength/weight relationship, which among others, results in: savings on fuel, significant reduction of greenhouse gas emissions, larger operational range or faster boats. Although carbon has been successfully deployed in other vessel types, such as fast ferries, recreation and high-end racing yachts, the usage of carbon remains unproved in the market of fast boats for professional use. The commercial shipping industry is very conservative and it is thus necessary to demonstrate the benefits of carbon fibre in the targeted market before large-scale commercialization. With ProZero project, TUCO will overcome prevailing market and entry barriers by partnering with key stakeholders and building solid reference cases. In addition, we will offer a full product range – the ProZero boat series - that can be built to order on a simple platform (using same tools) reducing the required initial investments of the whole series. The accomplishment of the project objectives will represent a significant business opportunity for TUCO, with an expected turnover of 23 Mio EUR, 5 years after commercialization. The SME instrument funding plays an important strategic role in the future business development of TUCO. After assessing the feasibility of ProZero in the SME phase 1 project, we intend to pursue our strategic vision of introducing a new line of fast boats for professional use to the market.

Keywords: carbon boats,fast rescue boats,daughter crafts,work boats
Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation (RiboLife)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1234227.61
Participants: 2
Project status: SIGNED

Modern cellular life strictly depends on DNA as genetic material. However, a large body of evidence infers the existence of a previous, more primitive biology in which RNA also stored information in cellular entities. Recreating a living cellular fossil representing this transition from an ancient RNA world to modern DNA-based life would fundamentally advance our understanding of our biology’s history, and enable us to explore its biological properties experimentally. However, the reengineering of existing molecular systems into a viable doppelganger of the Last Universal Common Ancestor (LUCA) or one of its precursors is extremely challenging. I propose to use a novel, combined top-down and bottom-up approach to create a modern-day doppelganger of LUCA by engineering bacterial hybrids with core cellular functions encoded on RNA. Using Darwinian Evolution as driver, my team and I will prototype and refine synthetic RNA-replicons through alternating replication in both cell-free and intracellular environments. This “dual evolution” approach will shape increasingly complex RNA networks capable of encoding complex genetic information. Following this, we will use these networks to create information-rich RNA chromosomes, enabling the transfer of essential genomic information from DNA to RNA. Finally, we will address this intergenomic transplantation by combining a novel RNA-delivery strategy with iterative rounds of genome deletion and complementation using state-of-the art CRISPR-Cas9 assisted genome editing. The proposed research will fundamentally advance synthetic biology, and could positively answer the transformative questions: Can we create, program and evolve life-like systems that can survive in both cell-free and intracellular environments? Can we use these entities to construct an alternative biology in which central cellular activities are encoded on genomes not made of DNA?

Keywords: synthetic cells,in vitro self replication,rna replication,directed evolution,genome transplantation,rna phages,origin of life
Full-scale Innovative integrated Tooling for Composite material Wing-box (FITCoW)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Romania
Call: Full Scale Innovative Integrated Tooling for Composite Material Wing Box [SAT] (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-02-01
End date: 2022-02-28
Duration (months): 37.0
Total project cost (EUR): 1247375.0
EU funding (EUR): 949362.5
Participants: 3
Project status: CLOSED

FITCoW addresses directly the challenges of AIRFRAME ITD - Reduce aviation environmental footprint through product performance improvements (drag, weight, versatility) and an eco-friendly life cycle including significant recyclability increase as well as optimized material streams applied to the category of 19-pax commuter aircraft. The global objectives presented for the CS2 program are particularized to this project as a reduction in the carbon dioxide emissions of the developed product and associated lifecycle and an increase in the EU competitiveness. FITCoW aims to implement tools that can reduce the recurring costs of low-volume production and, with this, benefit reducing carbon emissions through three different manners: in the manufacturing of the tooling itself as part of the project in comparison of tooling currently used, in the operation of the tooling in the manufacturing of the final aeronautical structures and in the operation of the manufactured aeronautical structures through the developed tooling.

Keywords: reduce aviation environmental footprint,eco friendly life cycle,composite materials
Molecular imaging and targeted therapy of the aggressive phenotype: development of uPAR theranostics for cancer patients (uPET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Denmark
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 2072000.0
EU funding (EUR): 2072000.0
Participants: 1
Project status: CLOSED

For practice of personalized medicine in cancer, non-invasive tools for diagnosing at the molecular level are needed. Molecular imaging methods are capable of this while at the same time circumventing sampling error as the whole tumor burden is evaluated. We recently developed and performed the first-ever clinical PET scan of uPAR, a proteolytic system known to be strongly associated with metastatic potential in most cancer forms. We believe this new concept of uPAR-PET is a major breakthrough and has the potential to become one of the most used PET tracers as it fulfils unmet needs in prostate and breast cancer. Based on this, together with additional proof-of-concept data we obtained on targeting uPAR for optical imaging and radionuclide therapy, we now plan to develop and take into patients these new technologies for improved outcome. Specific aims are to develop and translate into human use: 1. A PET uPAR imaging ligand platform for visualization of the aggressive phenotype and risk-stratification to be used in tailoring therapy, e.g. in prostate cancer to decide whether prostatectomy is necessary. 2. uPAR-PET combined with simultaneous 13C-hyperpolarized pyruvate MRSI (Warburg effect). This will increase prognostic power, refine tumor phenotyping and thereby allow for better tailoring of therapy and early prediction of treatment response. 3. A uPAR optical imaging technology for guiding removal of cancer tissue during surgery. This will help delineate cancer tissue for removal while leaving healthy tissue behind. We expect better outcome with removal of less tissue. 4. Selective radionuclide therapies targeting uPAR positive, invasive cancer cells using β or α emitters. Dose planning will be performed using uPAR-PET imaging. This image-therapy pairing is also known as theranostics. Our endeavour is ambitious, yet realistic considering our competencies and track-record. We expect cancer patients to benefit from our new methods within the 5 year time-frame.

Keywords: mesh,molecular imaging,neoplasma,positron emission tomography,nuclear medicine
Decoding the epigenetic signature of memory function in health and disease (DEPICODE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1729125.0
EU funding (EUR): 1729125.0
Participants: 1
Project status: CLOSED

The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context of neuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novel research field. It is however fair to say that the role of “epigenetics” in memory function is still met with some skepticism in the neurosciences, which is in part due to the fact that many of the current studies have been describing phenomena and mechanistic data to explain how epigenetic processes control memory function in health and disease are comparatively sparse. The major objective of this research proposal is to address this issue and help to consolidate the field of neuroepigenetics by providing insight to the mechanisms by which epigenetic processes contribute to memory formation under physiological and pathological conditions. More specifically I will ask how the epigenetic code is translated into cellular changes that mediate memory formation in health and disease and how can epigenetic mechanisms contribute to the transmission of cognitive phenotypes even across generations. Our results will not only provide import insight to the mechanisms that underlie memory formation but will also lay the basis for the development of novel and improved therapies for age-related cognitive disorders.

Keywords: memory consolidation,epigenetic processes,neurodegenerative diseases,histone modifications
Dipolar quantum gases of Dysprosium (DipInQuantum)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-05-29
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

In ultracold gases, novel physics can be explored taking advantage of the long-range, anisotropic interaction present between atoms or molecules with a large dipole. Such systems were probed first with Chromium atoms at the 5. Physikalisches Institut in Stuttgart (host institution). Lanthanide atoms carrying a stronger dipole moment have recently lifted high hopes for ground-breaking experiments with dipole-dipole interactions (DDI), our proposal plans on using Dysprosium. We aim to explore many-body physics associated with bosonic dipolar systems, in particular the spontaneous structuring of the ground state and the possible supersolid state. To do so we will use a high-resolution in-trap imaging of quasi-two- dimensional atomic clouds, with which we can image density modulations of the ground state revealing the first signs of long-range order. To pursue in this direction, we will study dipolar gases placed in tailored potentials, indeed the ground state in particular potential landscapes should display self-ordering and in some cases self-induced Josephson oscillations. Using the fermionic isotopes of Dysprosium, we plan on extending these methods to dipolar fermionic systems which are predicted to exhibit rich physics. Many proposals require an independent control of the short-range isotropic interaction. This requirement can be met by the use of magnetic Feshbach resonances present in Dysprosium. They offer the possibility to fine-tune the contact interaction despite the complex electronic structure of Dysprosium. Furthermore broad resonances will enable us to investigate few- body bound states, whose nature is modified in the presence of DDI.

Keywords: quantum gases,many body physics,dipole dipole interaction,feshbach resonances,supersolidity