Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Late Sumerian: The Afterlife of an Ancient Near Eastern Language (LASU)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-10-01
End date: 2031-09-30
Duration (months): 60.0
Total project cost (EUR): 1499803.0
EU funding (EUR): 1499803.0
Participants: 1
Project status: SIGNED

Sumerian is probably the earliest recorded language of humankind and its writings are among the most significant sources for studying the ancient Near East. It has been documented in the cuneiform script for over three millennia, from approximately 3300/3200 BCE to 74/5 CE. To date, however, a fundamental question in the field remains elusive: Why, if the last native Sumerian speaker passed away no later than the beginning of the second millennium BCE, did Sumerian continue to be used by the cultural and religious elite until the beginning of the Common Era? What was it about Sumerian that enabled it to trump Akkadian, Aramaic, Persian, Parthian, and many other languages of that time in the lottery of longevity? The main hypothesis of LASU is that Sumerian survived for so long because it was considered sacred. Two interrelated obstacles have prevented scholarship from advancing in this area of knowledge. First, Sumerian texts of the first millennium BCE, referred to as Late Sumerian, were often written in a bilingual for-mat, combining Sumerian and Akkadian, and are extremely challenging to translate. Second, modern scholars often consider this phase of Sumerian “corrupted” in comparison to the earlier stages, when it was likely still a spoken language. They therefore have tended to overlook Late Sumerian. Applying, for the first time, an innovative philological and religious-historical approach to tackle the longstanding puzzle of Sumerian linguistic longevity, LASU aims to apply a unique, language-order-based framework for deciphering Sumerian’s interactions with other languages of the multilingual ancient Near East of the first millennium BCE. The proposed study has the potential to open new vistas on the interactions among ancient languages, as well as lay the foundation for a ground-breaking understanding of how ancient societies dealt with multilingualism. Ultimately LASU is poised to establish a new subfield called “Late Sumerian Studies” within Assyriology.

Keywords: sumerian,first millennium bce,bilingualism,literature,magic,religion
Innovative Protein labelling strategies for Spectroscopic high resolution Techniques (InProSpecT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: TERMINATED

Protein structures, including their complexes, determine their specific function and the molecular working mechanisms. The astonishing developments in X-ray crystallography and cryo-EM allow insights into atomic levels of protein structures, however, commonly on their static, solid state conformations. Nuclear magnetic resonance (NMR) and single molecule fluorescence spectroscopy, on the other hand, allow observations of protein dynamics in solution, in real-time. In particular, specific intermediate and long-range interactions can be measured using paramagnetic resonance enhancements (PRE) or single molecule Förster Resonance Energy Transfer (smFRET), requiring site-specific labelling with paramagnetic or fluorescence probes, respectively. Naturally, the choice of the label and its covalent attachment to the protein are critical, however, traditional approaches rely on random cysteine labelling with only a handful of available probes, making measurements difficult to interpret and laborious. As such, there is an urgent demand to develop custom-tailored, selective, orthogonal, easy to use chemical biology probes with excellent spectroscopic properties (for smFRET and PRE) to drive the field of protein structure and dynamics. This proposal tackles current limitations in the peptide/protein labelling field by creating state-of-the-art fluorophores for red/far-red smFRET. Building on this, the best performing dyes will be unleashed to defined labelling of intrinsically disordered and native proteins, in vitro and in cellulo, respectively. Next, these concepts will be expanded to be merged with intramolecular PRE probes to combine to date mutually exclusive spectroscopic properties. InProSpecT (Innovative Protein labelling strategies for Spectroscopic high resolution Techniques) pushes a bottom-up approach, from fluorophore design and labelling strategies ultimately linking two worlds to allow unprecedented, simultaneous studies of protein distances and dynamics.

Keywords: chemical biology probes,single molecule foerster resonance energy transfer,paramagnetic resonance enhancement,intrinsically disorder proteins,orthogonal protein labelling
TPT0301 – A SAFER ALTERNATIVE TO CHRONIC PAIN MANAGEMENT (TPT0301)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

Chronic pain, affecting approximately 20% of adults in Europe and the US, represents a significant global health challenge. Traditional opioid-based treatments present severe risks, including addiction and overdose, with opioids causing nearly 50,000 deaths annually in the US alone. Tetra Pharm Technologies (TPT) addresses this crisis by developing safer, more effective alternatives through the modulation of the Endocannabinoid System (ECS). Our flagship product, TPT0301, utilizes proprietary nanotechnology-enhanced drug delivery to improve the bioavailability and therapeutic efficacy of cannabinoids. This innovation transforms fat-soluble molecules into a water-based matrix via a proprietary emulsification process, resulting in sub-micron oil droplets that ensure rapid and consistent absorption. This process offers a versatile platform that supports multiple administration routes, including oral, sublingual, and transdermal, providing flexibility and enhanced patient compliance. TPT0301 significantly lowers the risks of addiction and overdose associated with opioid treatments while minimizing common side effects such as constipation and respiratory depression. Pre-clinical trials have demonstrated superior absorption and efficacy compared to traditional formulations, with TPT0301 showing approximately 30-40% higher overall absorption. These findings underscore the potential of TPT0301 to revolutionize chronic pain management by offering sustained, effective pain relief without the need for escalating doses, thereby reducing tolerance and dependence risks. By 2024, TPT aims to advance TPT0301 to Phase I clinical trials at Hannover Medical School, following successful pre-clinical trials and the filing of a European patent application. Our strategic collaborations with leading institutions like the University of Copenhagen and the Technical University of Denmark, alongside key partnerships with CR2O, Triall, Kvantify, and Glysious, bolster our market potential.

Keywords: chronic pain,opioid based treatments,addiction,overdose,endocannabinoid system ecs,nanotechnology enhanced drug delivery,bioavailability,cannabinoids
In vitro diagnostics regulation assessment for the Biophotonic Nanoparticle-enabled Laser Blood Test for Early Detection of Pancreatic Cancer Hop On (LASERBLOOD HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 398125.0
EU funding (EUR): 398125.0
Participants: 2
Project status: CLOSED

The LASERBLOOD Horizon Europe project will expand its consortium by integrating COMPLEAR, significantly boosting the project's implementation and impact. COMPLEAR's inclusion will establish a comprehensive regulatory framework for the development of the laser-based In Vitro Diagnostic (IVD) technology for the early diagnosis of pancreatic cancer, the project's primary goal. With COMPLEAR expertise, LASERBLOOD will develop the technology in accordance with the European Union (EU) In Vitro Diagnostic Regulation (IVDR - Regulation EU 2017/746) and United States (US) Food and Drug Administration (FDA) requirements, streamlining future approvals and market adoption. This alignment with global standards will enhance the credibility, safety, and market readiness of LASERBLOOD’s technology. COMPLEAR's expertise will boost the development of the IVD prototype, enriching the consortium’s knowledge in IVD regulations and promoting effective transnational collaboration. In turn, COMPLEAR will gain valuable experience in scientific research and management of important projects, enhancing its role in the European research community. Its participation will support excellence in Widening countries and its integration into the LASERBLOOD consortium will expand the project’s outreach by fostering new networks in the diagnostics sectors and cross-border knowledge exchange. In addition, COMPLEAR will provide access to new talent pools and stakeholders. This collaboration will improve the overall quality and reach of the project.

Keywords: ivd,ivdr,fda,quality control,regulations,fluorescence lifetime,pdac,early diagnosis,pancreatic cancer,pancreas
Pan-Ideologies in Central Europe: Paradoxes of Right-Wing Self-Orientalism. (PANIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovakia,Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165059.52
EU funding (EUR): 165059.52
Participants: 2
Project status: SIGNED

The rise of right-wing populism in Central Europe coincides with the revival of pan-ideologies. Cases of Turanism promoted by the ruling party in Hungary and Pan-Slavism popular among right-wing activists in Slovakia pose a need to study these intellectual projects simultaneously in comparative and historical perspectives. The common feature of these competing traditions is a contradictory combination of racism and self-orientalism. Adepts of Turanism and Pan-Slavism often define themselves as belonging to a non-European race and simultaneously sympathize with typical far-right consensus on white supremacy. Why are pan-ideologies rooted in outdated pseudo-scientific theories so popular among right-wing populists of Central Europe today? To answer this question, we need to conduct a multidisciplinary study combining social anthropology and history. The proposed project aims to understand how modern adaptations of pan-ideologies differ from the original versions popular in the first half of the 20th century; and how these transformations correlate with the aims and resources (such as access to state institutions) of the ideologues. The novelty of the research project includes the suggestion to look at right-wing ideologies as phenomena embedded in the colonial and postcolonial history of the region. I propose to study Turanism and Pan-Slavism as products of contact zones, co-evolving and constantly influencing each other and affected by overlapping colonial regimes and postcolonial conditions. Following the guidelines of the Horizon Europe Programme to support social cohesion and inclusiveness, we need to conduct a focussed study of processes of polarization. The research project aims to explain how pan-ideologies attract new followers and why they are becoming popular again since the beginning of the last century.

Keywords: right wing ideologies,hungary,slovakia,panideologies,turanism,pan slavism,self orientalism,central europe
Language Ecology and Modality in Turn-Taking Acquisition (LETITIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: TERMINATED

The acquisition of turn-taking is pivotal to a child's pragmatic development; learning how and when to contribute and align with your interlocutor is a critical skill that enables smooth conversation. Despite extensive research on the development of turn-taking in spoken languages, we know little about how this unfolds in sign languages. Differences are likely as deaf children usually lack rich language models (ecology), and the visual-spatial nature of sign languages poses different challenges to manage visual attention (modality). To address this gap, this project investigates turn-taking development in an exceptional context: a Balinese village characterized by high incidence of deafness and widespread use of the local sign language, Kata Kolok. Here, children acquire Kata Kolok surrounded by a village of signing adults, providing an unparalleled opportunity to study how signing-rich ecologies shape turn-taking development in the visuo-spatial modality. I conduct two complementary studies: First, I follow the developmental trajectory of turn-taking of deaf children across 1-4 years, comparing their practices to turn-taking practices used by the adult signers in their community. For this, I draw on a unique interactive corpus of longitudinal naturalistic recordings of children who acquire Kata Kolok from their deaf caregivers from birth (KKCSC) and use a micro-level analysis of spontaneous conversations. Second, I use an experimental spot-the-difference task to further tease apart how conversational setting affects turn-taking, examining whether age of conversation partners (child vs adult) and number of interlocutors (two vs three or more) affect turn-taking behaviour among adult and child Kata Kolok signers. Merging threads from social interaction, sign language linguistics and language acquisition, the LETITIA project represents a paradigm shift in the study of sign language acquisition, grounding linguistic observations and analyses in real-world language use.

Keywords: turn taking social interaction language development rural sign language ecology modality conversation setting
Urban scAInce: why and how cities transform through artificial intelligence and their associated technologies (scAInce)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1998348.0
EU funding (EUR): 1998348.0
Participants: 1
Project status: SIGNED

Innovations have largely been the driver of human development; with the current Anthropocene peaking humanity’s influence on the livability of our planet. Technology is believed to be, once again, the solution to severe environmental, economic, and social crises, even though its implementation has a mixed track-record of finding solutions just to create new and sometimes more severe problems [8]. We ask whether more sustainable cities are smarter? Therefore, we will develop the urban scAInce theory transforming our understanding of how artificial intelligence and its associated technologies has, can, and will alter urban systems questioning whether the technology transformation leads to more sustainable living in our cities. We will achieve this goal by: (1) historically correlating urban sustainability outcomes with smart city technology adoption (2) evaluating privately-driven AI solutions on their impact to create more sustainable cities through a pre/post study (3) evaluating whether future cities will be sustainable by inaugurating a virtual open science city that allows its residents living across the world to jointly change their virtual environment, and (4) estimating the sustainability gap of 41000 cities through analyzed archetype cities.
Social justice or cancel culture? Gender-just language and academic freedom in Germany (GJL-AF-DE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

The research project focuses on one specific field of the current culture wars in Europe: what is framed as social justice by one side and cancel culture or woke by the other. The phenomenon will be studied in Germany, where these debates are particularly salient in politics and public discourse, and through two issues that occupy a central role in the controversies: 1. gender inclusive or (as termed in Germany) gender-just language and 2. academic freedom. The project’s main goal is to provide an account of the progressive side in the culture wars, and by that, to significantly contribute to better understanding a key conflict within contemporary politics and develop a democratic theory thereof. These debates have three specificities: First, they do not neatly map onto the culturally progressive/conservative cleavage: not only the conservative, but the culturally progressive side is divided too: postmodern, identity politics or intersectional Left (finding a suitable name is already part of the controversy), marxist Left, universalist or classical Liberals, various feminist strands are in fierce debates about the related issues among themselves, not with the right. Second, the two debates are emblematic of on-going culture war-struggles, hence studying them affords a better understanding of major developments in the politics of recognition, culture and language in the past decade. Third, academics play a major role in shaping public discourse and policies, not only through providing arguments for social movements and institutionalized politics, but also by intervening in the debates themselves, and with academia itself being a central site of conflict: through publicly discussing language use and invitation policies academia is carrying out a discussion of public relevance about what is socially acceptable and desirable.

Keywords: german politics,academic freedom,sociology of science,culture wars
Parameterized Complexity Through the Lens of Path Problems (PARAPATH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1499821.0
EU funding (EUR): 1499821.0
Participants: 1
Project status: SIGNED

Nowadays, numerous problems are known to be NP-hard, and hence unlikely to admit worst-case efficient algorithms. Fortunately, the field of Parameterized Complexity (PC) shows that the nutshell of hardness often lies in particular properties (called parameters) of the instances. Here, we answer the fundamental question: What makes an NP-hard problem hard? Specifically, how do different parameters of an NP-hard problem relate to its inherent difficulty? Based on this knowledge, we design efficient algorithms for wide-classes of instances of NP-hard problems. At the heart of PC lies the study of path (or cycle) problems. The inception of PC was inspired by the Graph Minors Theory, where the resolution of DISJOINT PATHS is a cornerstone. Moreover, the study of k-PATH has led to a large number of major breakthroughs in PC over the past three decades. Still, (i) fundamental questions concerning path problems have remained unanswered, and (ii) close to nothing is known about the relations between the different techniques to solve path problems. The overarching goal of this proposal is to build a unified, deep theory to analyze parameterized path problems. As known techniques to solve path problems rely, individually, on Graph Minors Theory, Extremal Combinatorics, Matroid Theory, Exterior Algebra, and more, I will draw new deep connections between these fields (towards unification). Based on the new theory, I believe that I will be able to answer decades-old questions in PC, which will revolutionize the power of this field. This includes the establishment of an Efficient Graph Minors Theory, an optimality program for color-coding-amenable problems, and a machinery to refute the existence of polynomial Turing kernels. Answers to these questions will substantially reshape the future of the design of parameterized algorithms, graph algorithms, and preprocessing procedures. Additionally, they will have high impact applications in practice.

Keywords: path problems,parameterized algorithms,parameterized complexity,graph minors,kernelization