Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nostalgia for the future: transnational belonging as a socio-cultural resource in Europe’s eastern peripheries (NOSTALGIAFUTURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Since the collapse of the Iron Curtain, nostalgia communities along Europe's eastern peripheries have been able to re-assert their transnational belonging in personally rewarding and socially beneficial ways. Through their homeland associations, private networks and NGOs, they have participated in collaborative cross-border activities in a range of sectors, including humanitarian aid, public health, environmental protection, tourism, heritage and arts. These activities point to a gradual, yet significant cultural shift within the traditionally backward-looking social groups, until recently primarily concerned with demanding justice for past injuries. Drawing on disciplines including cultural anthropology, history, human, cultural and political geography, “NostalgiaFuture” will map, document and contextually explain the involvement of two nostalgia communities - the Finns from ceded Karelia, and the Italians from Istria, Venezia-Giulia and parts of Dalmatia - in grassroots cross-border encounters and cooperative initiatives over the last two decades. In doing so, it will also develop greater understanding of the way heritage - both tangible and intangible - has the potential of either contributing to, or hindering the development of a culture of tolerance necessary for further cross-border integration. Findings from the two case studies will be compared and contrasted, generating insights that would not be possible if these areas were investigated separately. With Finland currently making headway in intensifying cultural exchanges with Russia, and Croatia set to join the EU in 2013, the project captures a moment in the history of European borderlands, when significant changes are on the horizon. The project will establish high quality international research links between Australia and select European and regional universities. Cross-institutional collaborative research, graduate student exchanges and long-term mentoring will continue beyond the life of the project.

Keywords: s311 cultural studies - cultural diversity,s411 collective memories - identities - lieux de memoire - oral history,soc,s412 cultural heritage,s106 globalization - migration - interethnic relations
Bombay Cinema's Encounter with the 1960s (1960S BOMBAY CINEMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-09-01
End date: 2014-08-31
Duration (months): 12.0
Total project cost (EUR): 154617.6
EU funding (EUR): 154617.6
Participants: 1
Project status: CLOSED

This project looks at the cultural resonance of the 1960s in the world of Bombay cinema. Indian cinema’s transition from black and white to colour produced an affective force field that impacted on the choice of locations, forms of mobility, the designing of interiors, the role of music and the cultural politics of stardom. Equally the 1960s was the decade of tourism.Tourism’s imaginative force taken together with the arrival of colour can open the window to an understanding of a transnational cinematic force that has not received adequate attention in the chronicled histories of Indian cinema. Travel across India’s landscape became a recurring feature in films, with trains and automobiles as the chosen modes of transportation. Thus, the hill station emerged in the 1960s as a picturesque space for romance. Exploration narratives abound in this decade with picnics, holidays, and other journeys forging an entirely new imagination of space. The fascination with landscape became critical to a new conception of the “outdoor” that looked distinctly different from earlier films. While the train and the automobile were mobilized for travel across India, by the mid 1960s we see the discovery of the “global” in a cluster of films that showcased travel to foreign cities like Paris, London, Tokyo and Rome. The travel narratives combined spectacular outdoor locations with lush interior spaces that included fashionable nightclubs, hotels, and lavish homes. The world of objects in interior spaces had to be organized for its capture on colour film stock, slowly changing the perceptual economy of the frame. Alongside these changes we witness shifts in the culture of stardom linked to new international currents in music, dance, fashion and youth culture. This project seeks to unpack the cinematic imagination that brought aviation, tourism, consumerism, colour film stock, fashion, and music into a distinct cultural configuration.

Keywords: cinema,bombay,colour,tourism,global,1960s,transnationalism,youth,india,europe,emerging economies,fashion,music
Role of the ATP-Binding Cassette Transporter Abcg2 in Cardiac Regeneration (CARDIAC ABC'S)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

Cardiac muscle death, without equivalent cardiomyocyte replacement, results in severe deficiencies in cardiac pump function both after myocardial infarction and in those chronic cardiomyopathies where apoptosis is prevalent. For this reason, understanding the molecular events that allow but severely limit cardiac regeneration in heart disease is of fundamental importance and may also hold immense translational potential. The ATP-Binding Cassette Transporter Abcg2 is expressed in various healthy organs and protects, against toxic compounds and their metabolites as well as against hypoxia and oxidative stress, conditions present during ischemic heart injury. Abcg2 is a common marker of tissue progenitor cells, including the dormant stem cells in adult mouse and human heart. Abcg2 plays a pivotal role in cardiac repair following infarction in mice, which to date has been ascribed to its protection of endothelial cells, the other site of Abcg2 expression in the heart. Its function in cardiac progenitor cells remains to be tested conclusively. With the use of genetically modified mice and fate-mapping techniques, this study will determine the functional role of an ATP-binding cassette transporter, Abcg2, in the clonogenicity of heart-derived progenitor cells in culture and the contribution of cells expressing this protein in new myocyte creation after myocardial infarction. We will: (1) Determine the role of Abcg2 in cardiac progenitor cells’ function, as defined by in vitro studies of clonal growth and its relationship with hyperoxic stress in culture, by disruption of Abcg2 in adult mice or isolated cells. (2) Establish whether conditional disruption of Abcg2 in adult mice influences cardiac function during recovery from experimental myocardial infarction. (3) Define the contribution of Abcg2-positive cells to cardiac myocyte creation after myocardial infarction, using fate mapping techniques with tamoxifen-dependent Cre recombinase driven by the Abcg2 locus.

Keywords: l312 stem cell biology,l407 cardiovascular diseases,l811 genetic engineering - transgenic organisms
Directed Evolution of Nonribosomal Peptide Synthetases (NRPS) Using the Novel BeSD Screening System (EVO-NRPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Nonribosomal peptides are a highly important class of natural products and display a broad spectrum of bioactivity, ranging from antimicrobial and immunosuppressant to anticancer. They are synthesized by non-ribosomal peptide synthetases (NRPSs), a diverse group of large multifunctional enzymes that operate as molecular assembly lines. They consist of modules that are responsible for coupling, processing and modification of an extending chain of amino acid monomers, heterocyclic rings and N-methylated residues. Re-programming of these unique biosynthetic routes should lead to a range of novel products of pharmaceutical importance. Previous studies which have focused on module swapping led to so called chimeric assembly-line enzymes. However most of those chimeras are heavily impaired due to the drastic changes applied, which could partially be compensated by site directed mutagenesis (SDM). SDM was also used to directly alter the specificity of several domains (e.g. the A-domain of TycA). Still no high throughput in vitro assay to evolve NRPS systems is available. We will therefore adapt the Megavalent Bead Surface Display (BeSD) system that has recently been developed for the directed evolution of protein binders to monitor peptide forming reactions by C-domains. In contrast to widely-used in vivo systems (such as bacterial, phage and yeast display) it is able to deal with larger library sizes and is not limited by host compatibility. BeSD will be the first in vitro system that is able to rank enzymes according to their bond forming efficiency since it can be coupled to fluorescence-activated cell sorting (FACS). Finally variants with altered specificities will be incorporated in modular assembly lines. This work will open the road to analyze larger, more diverse libraries of potential drug candidates. It is expected to be a crucial step towards the generation of novel NRPSs and is going to enrich our knowledge on how these multi-enzyme complexes work.

Keywords: directed evolution,nonribosomal peptide synthases,protein bead surface display,snap tag,promiscuity,site directed mutagenesis,fluorescence activated cell sorting,biocatalysis
Development of Advanced Renewable Photocatalytic Hydrogen Generation Technology (NRFORHF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

The project is aimed at developing the nanoscience and technology required for efficient production of hydrogen fuels by using H2O and solar energy as sources. It is basically a laboratory based research work, which includes the design and development of hierarchical Schottky nanostructures (HSNs) and thereby Solar Fuel Cells (SFC) for hydrogen fuels. Today, the realization of technology to harvest the solar radiation into various forms is a crucial and significant task since presently available conventional energy sources are fossil, hazardous and expensive. Recently, nanostructured materials, building blocks of various devices, have received great attention due to their large aspect ratio, surface area and unique physical and chemical properties. In this direction, the proposed project is aimed to develop a new class nanostructures i.e. HSNs and investigate their performance as photocatalyst. Initially, we will develop a high quality HSNs using three-step process: seeding, first order nanostructures (nanorods as stems), and second order hierarchical structures (nanoparticles, nanohairs, nanorods). Then, we will probe the impact of growth conditions on their physical and chemical properties. Finally, the best quality HSNs will be adopted for the development of SFCs and studied their photocatalytic performance as a Nano Reactor for Hydrogen Fuel (NRforHF).

Keywords: p212 nanophysics,p303 nanochemistry,p313 catalysis,p319 photochemistry,c128 nanomaterials,c119 structural properties of materials,c102 nanochemistry
Implementation of a multispecies model GADGET to the ecosystem of Flemish Cap and incorporation to the fisheries stock assessment of NAFO; a case study (GADCAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-13
End date: 2016-01-12
Duration (months): 24.0
Total project cost (EUR): 216034.2
EU funding (EUR): 216034.2
Participants: 1
Project status: CLOSED

Most of the worldwide marine fish resources are fully exploited or overexploited. There is a general consensus to change fisheries management toward a multispecies approach that considers species interactions and don´t overestimate stock-biomass per recruit, as it occurs with the current monospecific approach. GADGET has been considered by the Food and Agriculture Organization (FAO) the multispecies model with the greatest potential for practical advice in fisheries management. The Flemish Cap, a traditional fishing ground for European fleet in the Northwest Atlantic Fisheries Organization (NAFO) area 3M, experienced since 1988 clear alternations from predators (cod Gadus morhua and adult redfish Sebastes sp.) to preys (Northern shrimp Pandalus borealis and juvenile redfish), suggesting strong interconnections in the dynamic of these commercial species. The Working Group for the Ecosystem Approach to Fisheries Management (WGEAFM) leads an innovative framework in the NAFO area. Flemish Cap constitutes an ideal case study to start developing this framework due to its isolation, relative simplicity (cod, redfish and shrimp: 85% of total biomass) and the long and high quality database (since 1988). GADCAP deals with the creation of a GADGET multispecies model in the Flemish Cap, including cod, redfish and shrimp, considering the most relevant biological information, predator-prey consumption, and fleet characteristics. With the resulting multispecies model, several projections of population state will be conducted for all modeled species by introducing variations in recruitment, species interactions and fishing mortality. Different scenarios will be considered in the bosom of NAFO management strategies. Based in the innovative approach conducted by the WGEAFM, GADCAP represents an extraordinary opportunity to go further on in the development of the multispecies and ecosystem management approaches not just for the NAFO area, but also for other European fishing grounds

Keywords: multispecies models,fisheries,management,ecosystem approach,species interactions,stock assessment
Biophysics of the cell-matrix interface (CELL-MATRIX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 275138.8
EU funding (EUR): 275138.8
Participants: 1
Project status: CLOSED

The extracellular matrix is a critical determinant of cell structure and function, and understanding cell-matrix interactions is area of significant current interest. However, characterizing the relationship between the matrix and cells is intractable in vivo; tools are not available to adequate manipulate matrix properties in a living organism. Thus the approach to addressing this problem that has emerged is based on engineered microenvironments, where advanced fabrication technologies from physics and engineering are used to build well-defined environments. But even with the many technical advances in this area, a unifying conceptual framework in which to present findings is lacking. For example, how does one compare the response of cells on surfaces with certain types of protein patterns to those on surfaces with specific topographic features? Here we propose to advance the state of the art in using advanced nanometer scale patterning and fabrication technologies to study the relationship between topographic signals and biochemical signals in controlling cellular responses. We propose to use focused ion beam milling to produce fibers that are organized similar to natural extracellular matrix, and combine these with patterns of proteins to which cells are known to respond. These data will then be analyzed using a novel information theoretic framework, using a spatial information metric (the k-space information). By varying the topographic and biochemical signals independently, we will establish how information from these two classes of signals interacts to modulate structural and functional responses of cells.

Keywords: p219 biophysics,l301 morphology and functional imaging of cells,c121 surface modification,c128 nanomaterials
The Sense of Commitment: a minimal analogue of commitment for joint action (SENSE OF COMMITMENT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 138475.2
EU funding (EUR): 138475.2
Participants: 1
Project status: CLOSED

The project aims to establish the theoretical need for a minimal analogue of the concept of commitment, and to develop the notion of a sense of commitment as such a minimal analogue. The project focuses on commitments within the context of joint action, i.e. within a context that is both fundamental and paradigmatic for human sociality in general. The project aims to articulate the functions that commitments fulfill, and thus also the functions that a minimal analogue of commitment should be able to fulfill, as well as the demands that can be placed upon such a minimal analogue. In developing the notion of a sense of commitment as a minimal analogue, the project focuses on emotions and action-related cues as constitutive components of the sense of commitment. Thus, it aims to conceptualize the link between commitment and emotion, and specifically to develop the concept of feeling committed as a component of the sense of commitment, as well as to experimentally test hypotheses generated by philosophical analysis. Furthermore, it aims to conceptualize the link between habitual interaction patterns and commitment, and to develop the concept of acting committed as a further component of the sense of commitment, as well as to experimentally test hypotheses generated by the philosophical analysis.

Keywords: joint action,commitment,social cognition,social interaction,emotion,neo-sentimentalism,embodied cogntion,enactivism
Non-adiabatic quantum dynamics in novel optical superlattices (NODOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

The interdisciplinary boundary between the fields of quantum information science, condensed matter, and atomic physics is at the heart of the new field of "quantum engineering". One of the most important tools in this domain is ultracold atoms in optical lattices which are an ideal for testing condensed matter models and realising scalable quantum computation. For pratical implementation of quantum technology the challenge lies in realising the necessary dynamics with sufficient speed, sensitivity and robustness. This project will combine cutting-edge technologies of high resolution imaging and non destructive probing with an innovative realisation of super lattices to realise novel dynamics on the scale or microscopic, mesoscopic and macroscopic atom numbers. In addititon, I will use my extensive experience in the field of rapid, non-adiabatic processes to speed-up these processes allowing the step from proof of principle to the extremely high fidelities demanded for practical implementations.

Keywords: p107 atomic - molecular physics,p108 optics and quantum optics,p204 transport properties of condensed matter,p206 lattice dynamics
Evolution of mutator bacteria in a community context (EMBCC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The proposed fellowship is designed to provide to a promising post-doctoral specialization in the microbial evolutionary ecology field by pursuing a period of training in Centre for Ecology and Conservation, College of Life and Environmental Sciences at University of Exeter in the UK. Under the supervision of a world’s leading expert in this field, and with further theoretical training, the Fellow would employ this 2 year period to develop and expand upon her highly commended PhD research into how the evolution of Pseudomonas aeruginosa mutation rates is affected by natural microbial communities. This goal will be carry out by taking two different approaches: i) to study what is the impact of natural competitors in the evolution and adaptation of mutator bacteria in a soil community context by using a direct experimental evolution system; ii) to investigate what is the role of community complexity in the selection of P. aeruginosa mutators in cystic fibrosis (CF) chronic airways infections by exploring the correlation between community diversity and prevalence of P. aeruginosa mutators in artificial and natural CF communities. The project will be interdisciplinary; bridging the gap between microbial ecology and clinical microbiology fields and having broad ecological and medical consequences. In addition, with the inclusion of a return phase, this proposal will foster long-term collaborations between Exeter University, UK and Universidad Nacional de Cordoba, Argentina; favoring the transference of knowledge and enhancing EU scientific excellence in research related to microbiology, evolutionary ecology and infectious diseases in order to extend the current state-of-the-art of mutator bacteria evolutionary dynamics.

Keywords: pseudomonas aeruginosa,mutator,natural microbial community,evolutionary ecology,cystic fibrosis