Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Arabic Poetry in the Cairo Genizah (APCG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Ireland,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2026-06-30
Duration (months): 72.0
Total project cost (EUR): 1456246.0
EU funding (EUR): 1312587.0
Participants: 2
Project status: SIGNED

Poetry enjoys a special place in Arabic culture and literature. For centuries, Arabs of all faiths have considered poetry a key source for knowledge, intellectuality and wisdom. In the pre-Islamic era, poetry was considered as ‘the Arab knowledge’ and ‘the Arab cultural archive’, in which the social and cultural history, language, arts, music, religious and Arab’s human experience were stored and preserved. Being a part of Arabic culture, Jews of Arab lands equally enjoyed writing and reading poetry. APCG will investigate for the first time a hitherto neglected collection of Arabic poetry fragments written in Hebrew script (in Judaeo-Arabic), which has been preserved in arguably the most important Jewish treasure trove: the Cairo Genizah. The fragments, numbered in the hundreds, constitute a unique source for understanding medieval and Early Modern Egypt from three main perspectives: Arabic studies, Jewish social and cultural studies, and anthropological studies. The core aims of the project are: • to make the entirety of Arabic and Judaeo-Arabic poetry in the Cairo Genizah accessible to both academic scholars and to the public in a comprehensive database and in critical editions; • to reveal, through the study of poetry, hitherto hidden aspects of social and cultural history of the Jews in the Middle East with regard to literacy, education and intercommunal relations; • to explore hierarchies, interpersonal relationships and the social function of poetry in medieval and early modern Egypt through the study of Genizah poetry. To achieve the planned main objectives, APCG carries out a thorough interdisciplinary study of Genizah’s Arabic poetry. This approach involves research from philological, linguistic, literary, historical and anthropological perspectives.

Keywords: arabic poetry,the cairo genizah,judaeo arabic
Untangling fibroblast plasticity in vascular ageing (FIB-AGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Vascular ageing is a major cause of cardiovascular disease, but effective treatment for fibrotic effects of vascular ageing is lacking. Recent studies show that fibroblasts exhibit physiological and pathological functions beyond their central role in fibrosis. Supporting this view of the field, the host lab recently showed great intra-vascular fibroblast plasticity in atherosclerotic and ageing murine arteries. We hypothesize that vascular dysfunction and fibrosis with ageing originate from altered fibroblast plasticity and function. As part of my career restart, I will join an excellent laboratory, globally recognized for its expertise in advanced vascular biology research, embedded in a modern research institute, equipped with outstanding training facilities. I will combine my acquired scientific, technical and management skills with the infrastructure and expertise of the host lab to comprehensively study ageing-related fibroblast plasticity and to reveal the function of distinct fibroblast subsets in vascular function and ageing. I will combine the hosts cutting-edge high throughput techniques, including single cell sequencing and a newly established fibroblast functionality screening platform (FIBROSCREEN), with my expertise in vascular contractility assessment. I will study fibroblast function and plasticity in vivo, in vitro and in interventional studies ex vivo, in so far unimaginable detail. By sophisticated integration of this obtained data, I will identify key fibroblast players promoting vascular ageing and dysfunction. With this strategy, I will be the first to reveal subsets of fibroblasts in vascular ageing, to couple their function to vascular ageing progression and to suggest first interventional targets for future exploitation. Together with career guidance by the host, concomitant training opportunities, and a clear plan for dissemination this will ensure my integration into European academia as an independent researcher.

Keywords: fibroblasts,vascular ageing,fibrosis,plasticity
Latin as an Alien Script in the Medieval Latin East (GRAPH-EAST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1498768.0
EU funding (EUR): 1498768.0
Participants: 1
Project status: SIGNED

Most traffic signs in the Middle East today bear city names transcribed in Latin characters, making them familiar to all. It was the opposite in the 7th c. with the Arab conquest and the Hellenisation of the empire. The Latin script disappeared from the monumental graphic landscape of the Eastern Mediterranean. Progressively until the Ottoman expansion, pilgrims, merchants, crusaders from the West re-established hospices, churches, castles, and placed on monuments and artefacts inscriptions and graffiti using the Latin alphabet, i.e. signs now exogenous. They attempted through stone, painting, mosaic and metal to appropriate graphically, spatially and symbolically, parts of the East, including the Christian holy places. The study of these inscriptions faces 3 problems: the lack of a comprehensive corpus, the concept of Latin East suggesting a uniform Latinisation, conflating writing, language, culture and religious rite, and limited to the crusades, and a perspective that views Latin epigraphy as something static and unchanging, not taking into account the plurigraphic environment of the East. GRAPH-EAST aims to change this paradigm by exploring Latin epigraphic writing in the Eastern Mediterranean (7th-16th c.), from Greece and Turkey to Egypt via the coast of Palestine-Syria and Cyprus, in contact, interaction, and competition with Greek, Arabic, Hebrew, Armenian, Syriac etc. inscriptions, reflecting the political, religious, social and cultural issues of the area. The project proposes an innovative study of an outstanding body of texts, an estimated 2,500 inscriptions and graffiti, many unpublished, that opens a new field of research. It aims at understanding the representation and practice of the Latin script, alien in the Byzantine and Islamic empires, providing a connected history of epigraphy in this area, and analysing this migrant Latin writing through the prism of cultural transfers between West and East, with an international and pluridisciplinary team.

Keywords: medieval epigraphy,inscriptions,graffiti,writing systems,eastern mediterranean,scripts in contact,cultural studies,latin east,crusades,connected history,literacy,palaeography,latin script,written culture
Luminal pressure: a sculptor for mouse blastocyst self-organisation (Fluidblasto)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

An important morphogenetic event of mammalian embryogenesis is the formation of a blastocyst with a fluid-filled cavity, blastocoel, and the establishment of three cell types essential for implantation. Morphogenesis of the blastocyst begins with the emergence of multiple nascent cavities, which progressively coalesce to form one cavity segregating the cavity-facing primitive endoderm from the epiblast within the inner cell mass. While cell-to-cell gene expression heterogeneity is well characterised during this lineage specification, little is known about the physical principles governing self-organized blastocyst morphogenesis and patterning. In particular, changes in fluid pressure, cell shape and polarity during blastocyst formation remain uncharacterized. In this project, I will study the roles of fluid cavities in coordinating tissue mechanics, polarity and lineage specification. I will establish a novel micropressure technique to quantify the growth of luminal pressure during blastocyst development. Combining micropipette aspiration with high-resolution live-embryo imaging, I will characterize the impact of fluid pressure on trophectoderm fate specification through dynamic changes in cell shape and adhesion, and cytoskeletal remodeling. To assess the impact of fluid pressure on inner cell mass, I will study if cavity expansion induces apical polarisation and enhances primitive endoderm differentiation in cavity-facing cells. Combining laser ablation with light-sheet microscopy, we will build a spatio-temporal map of intercellular forces in vivo during blastocyst development. We will further manipulate the cavity size to study if fluid pressure is functionally required and sufficient for driving lineage segregation. This interdisciplinary and quantitative study will establish the novel role of fluid cavities and elucidate their interplay with biochemical signaling within the multi-cellular self-organization process.

Keywords: self organization,mouse blastocyst,tissue mechanics,fluid pressure,lineage segregation,polarity
Take-off for sustainable supply of woody biomass from agrarian pruning and plantation removal (uP_running)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Coordination and support actions
Countries involved: Ukraine,Spain,Italy,Spain,Greece,Greece,Croatia,France,Portugal
Call: Market uptake of existing and emerging sustainable bioenergy (H2020-LCE-2015-3, 2015)
Start date: 2016-04-01
End date: 2019-06-30
Duration (months): 39.0
Total project cost (EUR): 1992920.0
EU funding (EUR): 1992920.0
Participants: 12
Project status: CLOSED

uP_running project aims to set the path for the development of the bioenergy utilisation of agrarian pruning and plantation removal (APPR) wood obtained from vineyards, olive groves and fruit tree plantations. uP_running vocation is the abatement of the current immobilism of the value chain actors for the utilization of APPR woody biomass. For that purpose uP_running incorporates a set of straight actions aimed to reshape the sectors perception, to provide evidences of real success and replicable models to follow, as well as to promote the take-off for the utilisation of APPR biomass residues. An intense communication campaign will address the varied target audience with tailored messages and materials to raise the awareness. An impact on policy barriers and on the legal framework currently setting limits for the utilisation of APPR wood will be carried out through direct advocacy and lobbying work at national and EU level. Once the awareness is raised and the sector is released of hindering barriers, a snowball effect will be triggered through multiplicative and dissemination actions. First part of uP_running multiplicative strategy is to create a permanent capacity in Europe, by empowering national and regional agrarian associations, extension services and/or private consultants with capacities to give support for decision making to farmers, cooperatives and agro-industries owing the APPR residues. A call for entrepreneurship will put into operation the newly created capacities in 7 EU countries to promote the decision making of pioneer entrepreneurs. Setting up and running new APPR biomass value chains is the key for a self-replication and to further contribute to the development of the bio-economy in Europe. The actions will be initiated in a set of 4 “demo” countries (that together account for 50% of EU potential), replicated in 3 relevant EU countries, and extended through precursor actions to 7 additional EU countries.

Keywords: pruning,woodybiomass,farmer,agrarian,plantation,feedstock,consultancy
Brain stimulation of attention networks: examining old principles and developing new clinical applications (TMS_ATT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Attentional deficits are a frequent consequence of brain damage after stroke. Current treatment approaches using brain stimulation techniques such as transcranial magnetic stimulation (TMS) are based on two theoretical constructs, namely (1) inter-hemispheric inhibition within the dorsal attention network and (2) the presence of interactions between the ventral and dorsal attention network and. The proposed projects put these constructs to the test by combining TMS with neuroimaging and, based on these findings, explore novel brain connectivity based TMS treatments. Collectively, these projects advance current neurocognitive models of attentional control and lead to advanced TMS protocols that can alleviate attention deficits in patients.

Keywords: transcranial magnetic stimulation,positron emission tomography,functional magnetic resonance imaging,attention,hemineglect
A theory of global memory systems (REPLAY_DMN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2375000.0
EU funding (EUR): 2375000.0
Participants: 1
Project status: SIGNED

Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network, a set of areas that are most markedly connected and active during behavioural idleness, and memory replay, the spontaneous reactivation of neural patterns occurring during experience. I will test the hypothesis that the DMN plays a key role in memory replay processes. This theory, if confirmed, would bring important conceptual advances: to memory studies, as it would provide a mechanism supporting the formation and consolidation of complex memory representations. To the Default Mode Network field, as replay can be used as the “Rosetta Stone” to decipher the computations the DMN performs, moving beyond the connectivity, dynamics, and cognitive correlates, typical focus of DMN research. I will explore this theory by an experimental study of spontaneous neural activity over the whole mouse cortex, going from large field-of-view 2-photon imaging and high-volume electrophysiology for the single neuron scale, to voltage sensitive imaging and electrocorticography, to resting state fMRI, in animals running memory tasks. I will characterize the network dynamics and the encoding and replay of memories by quantifying conveyed information and assessing its nature (e.g. about simple percepts vs. complex events, remote vs. memories). I will also measure critical behaviour in these networks, and test whether neuronal avalanches, that occur in spontaneous activity, play a role in conveying information across distant brain areas. I will model the consequences of these mechanisms for computation by formulating a machine learning based model of memory formation and consolidation, endowing a deep network with critical properties and memory replay.

Keywords: default mode network,analysis of neural data,semantic memory,brain dynamics,cell assemblies
DataControl: Reliable, Secure and Comprehensive cloud backup as a service solution (DATACONTROL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-09-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays data is the most valuable asset of any organization, and its protection with backup and disaster recovery protocols is of utmost importance as 93% of companies that suffer major data losses file for bankruptcy within a year. New technology trends like IoT, open-source databases and cloud storage are revolutionizing how business store their data, and by 2020 it is expected that 78% of SMEs will backup their data directly on the cloud. While the cloud provides higher flexibility and data availability for businesses, it also creates new challenges, like data security, governance and geo-localization; challenges that have increased with the implementation of the GDPR last year. In order to respond to companies’ needs, we present DataControl, a complete and reliable backup management tool for all professionals working with Open Source databases stored in the cloud. It provides full integration with the top cloud hosting providers and most popular Open Source database management systems. DataControl’s backup encryption, verification and geo-locality capabilities will bring European companies a full control over their data, providing reliable backup operations. Founded in 2011, Severlnines currently employs 30 people and has deployed its popular ClusterControl product to clients worldwide. Thanks to this project, we will gain a privileged position in the global cloud backup solutions market. We will increase our turnover in more than €7.6 million revenues only 3 years after commercialization, reaching more than 1,500 clients through partnerships with small and medium-size European hosting and cloud providers.

Keywords: data protection,gdpr,cloud storage,databases,backup and disaster recovery
Dissecting the molecular pathogenesis of Legionella spp. in human lung models (OPTIMISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Aging populations and the increasing use of immune modulatory medical treatments have given rise to a growing incidence of opportunistic infections. Legionella species are Gram-negative environmental bacteria, which after accidental inhalation can cause respiratory infections with symptoms reaching from a mild flu to a severe pneumonia, called Legionnaires’ disease. Disease progression, i.e. clearance or exacerbation of infection, is determined by the immune status of the host and acute pneumonia usually associated with immune suppression and/or underlying pulmonary conditions, but the molecular mechanisms enhancing susceptibility are poorly understood. The infection biology of Legionella has been studied mostly in cellular infection models and mice, which do not develop human-like disease. As patients typically present only at late stages of infection, it is unclear to which extent findings from these models reflect the early processes which occur in the human lung during infection and how these drive the clinical outcomes. Similarly, these models fail to explain, why L. pneumophila serogroup 1 strains are the predominant cause of more than 90% of Legionnaires’ disease cases. In this project I, the applicant Dr. Flavia Viana, will tackle these knowledge gaps by establishing and using human precision cut lung tissue slices (hPCLS) and excorporeal perfused whole human lungs (Ex vivo lung perfusion (EVLP)) as infection models for Legionella. I will determine if and how virulence of different Legionella isolates in these models correlates with their relevance in the clinical practice, analyse the transcriptional responses of all cell types in the infected human tissue using single cell transcriptomics and employ histology, state-of-the-art confocal and light sheet live microscopy, to visualise infection dynamics and host responses, providing unprecedented insight into the molecular events leading to the development of Legionnaires’ disease.

Keywords: legionella,bacterial pathogenesis,virulence factors,host pathogen interaction,respiratory medicine,lung tissue models,precision cut lung slices,single cell transcriptomics