Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ROles of ePitranscriptomic in diseasES (ROPES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Spain,Italy,Italy,Switzerland,Belgium,Sweden,Poland,Czechia
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-12-01
End date: 2025-05-31
Duration (months): 54.0
Total project cost (EUR): 3095829.0
EU funding (EUR): 3095829.0
Participants: 11
Project status: SIGNED

Epitranscriptomics is the study of RNA modifications and their role in the regulation of gene expression. As happened for DNA, extensive covalent modification of RNA was found already in the 70s. Nevertheless, a spectacular expansion of epitranscriptomics occurred mostly in the past seven years, when an extensive layer of base decorations was discovered in mRNAs and shown to undergo cell modulation. These modifications produce programmable fluctuations in mRNA levels, translatability and subcellular compartmentalization, affecting primary cell programs such as cell differentiation and response to stress. We thus anticipate that RNA modifications will prove as important as chromatin dynamics in shaping cell phenotypes. This emerging field is hence crucial for both basic science and application to human disease. Epitranscriptomic would provide the missing link between genomic variability and cellular phenotypes, contributing to explaining the cause of specific diseases and developing novel therapies. Epitranscriptomic research is dominated by the US and China, with the EU lagging behind. We thus need to rapidly create a European framework to integrate and accelerate research efforts and industrial applications in this emerging field. To address this major European need, ROPES will train a group of Early Stage Researchers who will become the seed of the European epitranscriptome science of this decade. They will join a recently established network of academic research groups and biotech companies devoted to advancing our understanding of RNA modifications while promoting the development of new biomarkers and therapies. Focusing on RNA editing and m6A methylation, ROPES will investigate disease mechanisms and new therapies in the fields of cancer, stem cell diseases and innate immunity, while developing innovative epitranscriptomics methods. The ROPES European Training Network is the first European effort to tackle the epitranscriptome for the advancement of medicine.

Keywords: epitranscriptomics,rna modifications,translation,mrna stability,human disease,cancer,stem cell diseases,innate immunity,rna editing,single cell,bioinformatics
Resource Efficient Food and dRink for the Entire Supply cHain (REFRESH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Germany,Spain,Hungary,China,Belgium,Slovenia,Sweden,Sweden,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom,United Kingdom,Kenya,United Kingdom,United Kingdom
Call: A systems approach for the reduction, recycling and reuse of food waste (H2020-WASTE-2014-two-stage, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 9444757.79
EU funding (EUR): 8999757.79
Participants: 29
Project status: CLOSED

The overall aim of the REFRESH project is to contribute significantly towards the objective of reducing food waste across the EU by 30% by 2025 (which amounts to between 25 to 40 million tonnes of food not being wasted in 2025[1], worth tens of billions of Euros a year) and maximizing the value from unavoidable food waste and packaging materials. To achieve this ambitious goal, we will adopt a systemic approach and use cutting edge science to enable action by businesses, consumers and public authorities. A central ambition of the REFRESH project is to develop a ‘Framework for Action’ model that is based on strategic agreements across all stages of the supply chain (backed by Governments), delivered through collaborative working and supported by evidence-based tools to allow targeted, cost effective interventions. Success will support transformation towards a more sustainable and secure EU food system, benefitting Europe’s economy, environment and society.

Keywords: food waste reduction,waste valorisation,systemic approach,framework for action,public private collaboration,consumer science,socio economic modelling,environmental impact modelling
Remote sensing of photosynthetic traits for high latitude plant productivity modelling (RESOLVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The arctic is predicted to warm faster and to a greater extent than anywhere on earth. Environmental drivers such as increased temperature and atmospheric CO2 concentration, are resulting in unprecedented changes to the structure, function and/or species composition of Arctic-Boreal biome (ABB) vegetation. However, the ecosystem response to a changing climate varies spatially within the ABB, even in areas exposed to the same changes in climate. Changes in vegetation dynamics have been documented from a range of sources, including atmospheric CO2 data, forest inventories and other field measurements. However, accounting for the spatial-dependence of climate-vegetation-ecosystem feedbacks to model plant carbon uptake is challenging over biome scales. Accurately quantifying the photosynthetic carbon uptake by vegetation is important to carbon budgets, due to its magnitude and inter-annual variability. A particularly time-sensitive question is whether potential increases in vegetation productivity will offset CO2 emissions from melting permafrost, and what the net impacts will be on the terrestrial carbon sink. NDVI satellite-derived data has been well-used by ecologists to reveal ‘greening’ or ‘browning’ trends across the biome and a longer growing season. However, NDVI saturates at moderate leaf chlorophyll (Chl) and LAI values, leading to unreliable relationships with vegetation productivity. Recent developments in remote sensing methods and satellite technologies and has opened up exciting new opportunities to use fluorescence and Chl as indicators of plant physiological status, to address biome-scale questions on climate-induced changes in vegetation productivity. This research will contribute to: improving our understanding of the spatially-dependent dominant environmental drivers affecting ABB vegetation change at local and regional scales, determining the terrestrial carbon budget for the ABB, and the consequent implications on atmospheric CO2 concentration

Keywords: arctic,boreal,climate change,vegetation productivity,chlorophyll fluorescence,leaf chlorophyll content,ndvi,ecosystem modelling,vcmax
Next Generation Internet Explorers Program (NGI Explorers)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Spain,France,United Kingdom
Call: EU-US collaboration on NGI (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-02-28
Duration (months): 38.0
Total project cost (EUR): 1503836.26
EU funding (EUR): 1497201.25
Participants: 4
Project status: CLOSED

The NGI Explorers Program vision is to leverage the EU-US researchers exchange and foster “made in Europe” NGI products and services, through the engagement of Internet researchers in understanding US different perspectives, vision, values and technology approaches, for an uplifted research mindset. The objective of the programme is to support the integration of the EU-US communities, exchange of Internet researchers and innovators, share of experiences and best practices and organize community events. Therefore, we have (1) designed an agile 2-step fellowship programme to favour the growth of high potential Internet researchers from hi-tech startups, SMEs, mid-caps, research centres or academia, to gather and exchange Next Generation Internet knowledge, experiences and concepts, and develop projects with the goal of creating concrete NGI services and products 'Made in Europe'; and (2) integrated this with a dynamic and captivated NGI community through an ecosystem building methodology, developed to attract the key European and US NGI players and build/ exploit synergies. We start the project with 16 US Exchange Nodes engaged (all signed Letter of Commitment). At the end the programme will have supported 30-50 fellows (3-6 months programmes), through >25 US Exchange Nodes, engaged more than 1000 participants in its activities and build the structure for the successful EU-US collaboration in the development of NGI products and services. The NGI Explorers consortium is a fusion of: Tech founders and startups community (F6S), an International innovation and Tech-transfer specialists (IINV) and R&D consultant (ZABALA).

Keywords: fellowship programme,next generation internet,ecosystem
Novel Extended solids based on N=C chemistry for future Na-ion Batteries (NExtNCNaBatt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-07-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The large and increasing demand for energies with a low CO2 footprint has prompted intense research and development on renewable energies as well as on sustainable electrochemical energy storage systems to fully utilize them. This requires the development and understanding of battery chemistries from earth abundant low cost raw materials, which can be easily synthesized, with Na-ion batteries (NIBs) at the forefront of meeting these requirements. While in Na-ion batteries most efforts are made to investigate materials that are essentially derivatives of Li chemistry, there are opportunities to look at very different chemistries which were not explored for Li ion batteries or just work much better in Na batteries. The goal of this NExtNCNaBatt project is the investigation of designed novel materials based on the N=C derived anions and their application as electrodes for sodium ion batteries. The major objective is the establishment of a fundamental understanding of the Na to N=C interactions in Novel Extended solids based on the NC chemistry for Na-ion batteries which will be achieved through the study of structural changes in the bulk by in-situ x-ray diffraction studies, as well as local changes in the atomic environment followed by advanced spectroscopic studies. Na-ion batteries are just at the birth of commercialization, and therefore materials developed in this project could be timely incorporated into next generation prototypes and first commercial Na-ion batteries. Additionally, these new materials and the understanding of the alkali to NC interactions will be relevant to many other areas of research where electrochemical transformations occur, such as other battery chemistries, capacitors, electrochromic displays, and as photocatalysts, all systems where the understanding of the heterogeneous reactions between the solid electrode and ions from a liquid electrolyte are of critical importance.

Keywords: energy storage,na ion batteries,carbodiimides,cofs
Empowering expectations for health and disease: Development of a pioneering training tool (TRAIN-HEAL-TH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-08-01
End date: 2018-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Expectations about health and disease are known to directly affect health and treatment outcomes. In the EXPECT-HEALTH project, my research group is unravelling the central mechanisms of how expectations affect immune and endocrine responses and related health outcomes, through the use of pioneering multidisciplinary methods in healthy and clinical populations. Ultimate goal of gaining this knowledge is to apply it in innovative therapeutic interventions. In order to reach this goal, an innovative multimodal training tool based on the dual expectancy learning approach (including implicit and explicit processes) proposed in the EXPECT-HEAL-TH project will be developed and brought to the pre-demonstration phase, making optimal use of new technology including implicit and explicit methods in the area of eHealth and serious gaming. I propose this proof of concept, termed TRAIN-HEAL-TH, to facilitate the design and development process in 4 stages: 1) development of innovative training tools, 2) usability and functionality testing of multimodal training tools, 3) pilot feasibility testing of multimodal training tools in relevant target populations and improving training tools based on pilot testing, and 4) evaluation of potential commercialisation opportunities. This interdisciplinary, cross-boundary project aims to design a training tool that can be applied in healthy as well as clinical populations. The development process, including potential professional commercialisation opportunities, will be facilitated and evaluated in this study using state of the art knowledge within the field of eHealth and serious gaming. The project will result in a multimodal training tool that may be tailored to individual target populations for disease prevention and improvement of health outcomes. For the first time, the theoretical underpinnings of EXPECT-HEAL-TH are translated into innovative therapeutic tools that have potential for a broad range of societal and economic benefits.

Keywords: intervention development,expectancy learning,placebo effects,conditioning,ehealth,serious gaming,implicit and explicit processes
Deciphering the network of microbial, environmental and physical factors underlying aggregation and enhanced performance in syntrophic microorganism communities (SYNAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 992622.0
EU funding (EUR): 992622.0
Participants: 1
Project status: SIGNED

Syntrophic microorganisms perform unique and crucial tasks in microbial processes used for sustainable energy (methane) and nutrient recovery from various organic waste streams. These syntrophic microorganisms cooperate to metabolically degrade acids but there are barriers and challenges to these organisms reaching their full potential, which restricts productivity and stability in the biomethane process. The cooperative lifestyle and cultivation of syntrophic microorganisms strongly points towards linkage between syntrophic cell aggregation (SYNAG) and acid-degrading activities that open up opportunities for biotechnology strategies. In this project, I will provide fundamental understanding of environmental, microbial, and physical effects on cell aggregating activities in syntrophic communities. To do so, I will take advantage of a unique collection of syntrophic cultures obtained through extensive research. Firstly, I will unravel mechanisms used for aggregation by comparing the transcriptional profiles of syntrophic cultures and develop molecular analyses to quantify aggregating activities. The second part of the project will focus on development of a cultivation system and in-situ detection that will maintain the complex syntrophic interactions intact. These methods will be combined for parallel analyses of cell aggregation in syntrophic communities and their responses in to a wide spectrum of factors with relevance to anaerobic processes. Aggregating activities will further be linked to effects on acid degradation rates and resistance of the microbial community towards stress. In the final part of the project, factors that enhance aggregating activities will be assessed in systems that mimic the real situation in anaerobic systems. SYNAG will thus provide fundamental understanding of syntrophic ecology and physiology that will be highly valuable in anaerobic techniques that has great expansion potential in future work of building biomass based platforms.

Keywords: biomethane biogas production,syntrophic microorganisms,acid degradation,cell aggregation,biotechnology strategies
Control of turbulent friction force (CTFF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,Sweden,China,France,France,United States,United Kingdom,Canada,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-12-01
End date: 2022-09-30
Duration (months): 58.0
Total project cost (EUR): 760500.0
EU funding (EUR): 504000.0
Participants: 11
Project status: SIGNED

CTFF is a major interdisciplinary project that combines wisdoms in three academic disciplines: Heat Transfer, Fluid Physics and Plasma Physics, to address the research problem on both active and passive control of turbulent friction force. The main focus is on developing techniques for the control of near-wall turbulent structures and the reduction of turbulent friction force, specifically at conditions relevant to engineering practices, by coordinating the efforts of European, the US and Chinese experts specialized in these three different but overlapping domains. New materials will be examined, novel numerical algorithms will be developed, and the numerical results will be tested in physical experiments. In brief, the main objective of this project is to coordinate the action of a group of Universities and enterprises, with complementary expertise in three disciplines from European countries, China and the US, to build and test an optimal solution for the reduction of turbulent friction drag, thereby facilitating the successful implementation of friction force control in engineering practices.

Keywords: drag reduction,plasma actuator,superhydrophobic,heat transfer
In-silico boosted, pest prevention and off-season focused IPM against new and emerging fruit flies ('OFF-Season' FF-IPM) (FF-IPM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,South Africa,Spain,Israel,Austria,Australia,Germany,Italy,Cyprus,Croatia,China,Poland,Belgium,Greece,Poland,Greece,France,United States,Portugal
Call: New and emerging risks to plant health (H2020-SFS-2018-2, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 6004252.5
EU funding (EUR): 6004252.5
Participants: 22
Project status: SIGNED

The FF-IPM project targets three highly polyphagous fruit fly (FF) species (Tephritidae) that cause devastating losses in the fresh fruit producing industry, the Mediterranean fruit fly (Ceratitis capitata), a serious emerging pest in northern temperate areas of Europe, the Oriental fruit fly (Bactrocera dorsalis) and the peach fruit fly (B. zonata) two major new (invasive) pests, which pose an imminent threat to European horticulture. The project aims to introduce in-silico supported prevention, detection and Integrated Pest Management (IPM) approaches for both new and emerging FF, based on spatial modelling across a wide range of spatial levels, novel decision support systems, and new knowledge regarding biological traits of the target species, fruit trading and socioeconomics. FF-IPM introduces a fundamental paradigm shift in IPM towards “OFF-Season” management of FF by targeting the overwintering generation when population undergoes significant bottlenecks, preventing, this way, population growth later in season. “ON-Season” control approaches will be generated for different spatial scales considering both existing and developed by FF-IPM tools and services. Innovative prevention tools to track FF infested fruit (e-Nose) and rapidly identify intercepted specimens (Rapid-Molecular-Pest-ID tools) in imported commodities and at processing industries will be produced. Species specific e-trapping systems for the three-target FF will be advanced and employed by novel detection strategies based on spatial modelling. Both “ON and OFF-Season” IPM approaches and detection strategies will be validated in selected locations in eight different countries. FF-IPM generated data on FF response under stress conditions, overwintering dynamics, establishment and dispersion patterns of low population densities combined with advanced spatial population modeling are expected to contribute towards understanding drivers of emerging and new pests under climate change scenarios.

Keywords: diptera,pest management,non european pests,global warming,establishment,plant health,quarantine regulations,biosecurity,invasion,emerging pests