Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Droplet printable microfluidic arrays for high-throughput screening of 3D cell culture (DropMicS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Poland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: SIGNED

This project will develop high-throughput 3D cell culture devices with perfusion by interfacing microfluidics and droplet printing technologies and subsequently applying them to model neuro-development disorders. For decades, 2D cell culture followed by animal testing has been the standard for therapeutic drug discovery. 3D systems have the potential to recreate more faithful physiological conditions (cell interactions, gradients, perfusion, flow). Thus, they are expected to be more predictive for efficacy and toxicity than 2D systems and minimize the use of animals. However, there is currently no 3D model which enables high-throughput (HT) and perfusion at once: spheroids and organoids in plates can be HT but without perfusion, pressure-driven microfluidics has perfusion but is not HT, droplet microfluidics is HT but cannot handle large drug libraries and has no perfusion. Here, we will leverage the physics of wetting and capillarity to design chamber arrays with liquid-trapping geometries, which can be entirely operated by external droplet injection. We will set up designs and protocols for the embedding of cells in 3D hydrogel matrices and submit them to perfusion of medium and drug, including uniform or gradient conditions in each chamber. We will demonstrate the HT interfacing with droplet printers. Finally, we will apply the device to screen compounds and monitor the modulation of microglia (the immune cell of the brain) inflammation that affects the lives of >2 million preterm babies every year.

Keywords: microfluidics,printing,3d cell culture,neurodevelopment disorders,high throughput,drug screening
Leveraging the immune system for breast cancer prevention (IMMUNOPREVENT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Damaged cells, including precancerous cells, continuously accumulate in healthy tissues, but they are identified and eliminated by the immune system in a continuous process named immunosurveillance. Therefore, effective immunosurveillance plays an essential role in preventing cancer development. IMMUNOPREVENT aims to understand how aberrant precursor breast cancer cells escape from immune surveillance, and whether we can leverage this knowledge for future cancer prevention strategies for women at high risk of developing breast cancer. Mutations in the DNA repair genes BRCA1 and BRCA2 confer a 70% lifetime risk of breast cancer, in contrast to the 13% risk in the general female population. The majority of BRCA mutations are inherited, but there are no effective breast cancer prevention options for BRCA carriers besides the invasive prophylactic mastectomy. Therefore, this is an unmet clinical need that demands new knowledge that can be translated into prevention strategies in the future. In this project, I will investigate the potential tumour protective role of LCOR in clearing BRCA-deficient cancer-initiating cells before tumour establishment. LCOR enhances tumour immunogenicity by inducing tumour antigen presentation, thus rendering breast cancer cells visible and vulnerable to immune attack. However, its role in early oncogenesis remains unknown. Here, employing a novel mouse model for mammary gland-specific loss of Lcor and Brca1, I will interrogate the role of LCOR in premalignant clonal dynamics, tumour development and early immune evasion. This knowledge will expand our general understanding of the early immune-mediated events in the premalignant mammary gland that eventually lead to cancer initiation. With this fellowship I will gain skills and knowledge on immune oncology and the results generated will be the foundation for future research lines on immunotherapy for breast cancer prevention that I will pursue as an independent researcher.

Keywords: brca,immunotherapy,preneoplasia,immunosurveillance,antigen presentation,mammary gland biology
DISCOVERY, IDENTIFICATION, APPLICATION, AND MONITORING OF DEVELOPED SOLUTIONS FOR INNOVATION FUND (DIAMONDS4IF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Coordination and support actions
Countries involved: Germany,Norway,Italy
Call: Support for the deployment of R&I results for climate mitigation. Synergies with the ETS Innovation Fund (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1288191.81
EU funding (EUR): 901734.27
Participants: 6
Project status: SIGNED

To achieve the aim of the topic, a systematic approach will be developed and applied to select H2020 results and owners, to support the project development and finally to derive Innovation Fund-ready projects. The ETS Innovation Fund (IF) fosters low-carbon processes and technologies – and many results from H2020 provide promising solutions to be deployed. However, translating R&D results into products and processes and developing viable business cases is a major effort. Beyond that, it is a further great step to mobilise investors and stakeholders to make the projects fly. The IF regulations are challenging for the industry. To cope with all challenges related to the project development and preparation phase of future IF projects, DIAMONDS4IF is designed to: a) securing the viability and readiness of the projects, b) enabling applicants to prepare IF applications, c) developing a comprehensive approach towards stakeholders, investors, the public, and across the value chain, d) creating understanding of and preparing compliance with relevant regulations, guidelines, and framework conditions and e) solving questions and challenges arising from the project planning in line with funding requirements and award criteria. Through exemplary work on specific use cases in the field of renewable energy, a toolbox with the necessary methods and tools will be developed and applied. One of the major outputs of the project will be at least 5 sound proposals including the detailed plans for scalability, commercialisation, and financial models to be presented to the IF. Over the medium term, DIAMONDS4IF will develop and nurture a continuous innovation pipeline from H2020 innovations to deployment, which will exploit the synergies between the programmes. The use cases will e.g. directly implement REPower and climate relevant projects, comprising for example ~100MW offshore hybrid energy; 1.5GW of PV manufacturing capacity; 10GW of resource-efficient wafer production in Europe.

Keywords: renewable energy,pv,solar,offshore,wind,innovation fund,wafer
Extinction, replacement and trade: Tracking 100,000 years of horse evolution in Iberia (ZEPHYRUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 210984.88
EU funding (EUR): 210984.88
Participants: 3
Project status: CLOSED

Horses provided humans with the ability to travel well above their own speed and changed the way they made war. As such, the domestication of the horse ~5,500 years ago, represents a historical turning point in human history. Throughout the whole Upper Palaeolithic period and right into the Holocene, Iberia has always offered favorable climatic conditions for equine populations to thrive. Much remains to be discovered on the horses that once roamed the region. For instance, the true nature and diversity of the Iberian horse represented in the famous cave paintings of Altamira remains unknown. The exact dynamics underlying their replacement by foreign domestic horses during the Bronze Age is also debated. Similarly, while the Muslim expansion of the C7th-C9th is known to have reshaped the genetic makeup of horses across Europe, the exact impact of this expansion in Iberia is unknown, despite Muslim kingdoms being maintained there up until the C15th. The same holds true for previous equine civilizations such as the Phoenicians who traded in the area, or the Romans who largelly expanded into the region. Finally, the true extinction timing of the Iberian zebro, an European wild ass closely related to Asian hemiones, is contentious, with some scholars advocating survival up until the Middle Ages. By focusing on a single region, Iberia, the ZEPHYRUS project provides the unique opportunity to solve many long-standing debates in horse evolution and (pre-)history. Through the development of innovative genotyping solutions and state-of-the-art approaches in ancient DNA research, ZEPHYRUS will genetically predict how the physical traits of Iberian horses have changed since the Upper Palaeolithic and how different equine civilizations have remodelled the Iberian horse through space and time. Reciprocally, ZEPHYRUS will unveil the influence that Iberian horses have had an how they contributed to reshaping the genetic makeup of other European regions.

Keywords: ancient dna,animal domestication,genomics,iberian peninsula,horse,mule,zebro,high throughput dna sequencing
AI Factory for Copernicus Data at Scale (DaFab)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: France,Greece,Luxembourg,United Kingdom,Slovenia,Switzerland
Call: Large-scale Copernicus data uptake with AI and HPC (HORIZON-EUSPA-2022-SPACE, 2022)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2953795.0
EU funding (EUR): 2953795.0
Participants: 8
Project status: SIGNED

Despite the success of Copernicus data, the European Earth Observation (EO) data market is only one-third of the size of the North American market. However, the market is expected to double over the next decade. Various sectors, such as insurance, food safety, environmental monitoring, and precision agriculture, are anticipated to capture most of the growth. In this context, DaFab has identified three primary challenges that must be addressed to leverage the full potential of Copernicus' information. Firstly, the timely analysis of EO data is critical for decision-makers to make informed decisions. To address this challenge, DaFab invests in novel hardware techniques dedicated to AI and federated computing techniques, which are capable of handling large high-resolution datasets and can enable real-time applications. Secondly, the massive amounts of Copernicus data make it challenging to identify the most relevant datasets for specific purposes, and the siloed nature of EO data further compounds this problem. To address this challenge, DaFab invests in semantic web techniques and public metadata catalogs to enable searching Copernicus images by features and relationships. Finally, the sustainability of analysis by-products is critical for efficient data management. To address this challenge, DaFab invests in cloud-computing techniques and public metadata catalogs, providing a unified solution for searching both raw Copernicus and by-products by features and relationships. By addressing these challenges, DaFab aims to unlock the full potential of Copernicus data and drive growth in the European EO data market.

Keywords: earth observation,ai,metadata,ontology,neuromorphic computing,distributed workflows
Concept Development of a System for Pods and Pod-Carriers to be used as Moving Infrastructures mainly for Rail, but as well for Road and Ropeways (Pods4Rail)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Research and Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: Germany,Austria,France,Netherlands,Sweden,Spain,Czechia
Call: Conceptual development of Automated Multi-Modal Mobility-Systems (“Moving Infrastructures”) (HORIZON-ER-JU-2022-02, 2022)
Start date: 2023-09-01
End date: 2026-06-30
Duration (months): 34.0
Total project cost (EUR): 3436407.08
EU funding (EUR): 2999983.1
Participants: 15
Project status: SIGNED

Two major issues of secondary lines rail transport are need to change the train for many destinations and to be bound to a timetable. Pods can be used to adopt rail transport better to the users demand by higher flexibility and efficiency as well as realising on-demand rail transport. The Project Pods4Rail aims to develop a concept for Pods and Pod-Carriers on Railway in order show the approach. Pod-carriers are serving as a moving infrastructure and the pods are loaded and locked on them for the transport. The main focus in Pods4Rail is the rail pod-carrier, which is presented in detail. Nevertheless, Pod-Carrier for Road and Ropeways are taken into consideration on a conceptual level to ensure the transferability of the concept. Related use cases and business cases are identified and analysed.

Keywords: pod,pod carrier,multimodal mobility
Support Engineering in singLe-atoM cAtalysts for light-driven C-X coupling processes (SELMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Despite the unprecedented development in the field of single-atom catalysts, these materials still suffer from major challenges, including, among others, the difficulty of reaching high loadings of catalytically-active metals in atomically dispersed form. To solve this issue, the choice of an appropriate support is critical, as this strategy can effectively modulate the metal-support interaction. In this MSCA project, I aim to design a novel family of single-atom catalysts (SACs) based on modified carbon nitride supports to overcome challenges related to metal immobilization and stabilization in single-atom catalysts. This will be accomplished by engineering carbon nitride materials with altered C/N stoichiometry ratios. The catalytic potential of the developed SACs will be evaluated in photocatalytic C-X coupling reactions (where X = O or N) under visible-light conditions, an important reaction for the production of value-added chemicals. The exploitation of in situ/operando characterization methods will allow us to gain a more in-depth understanding of the structural properties and evolution of reaction active sites under working conditions. This MSCA will open new scientific avenues in the field of sustainable single-atom catalysis. The interdisciplinary nature of this MSCA project will also equip me with a diverse array of scientific and soft skills, including project management, leadership through mentoring, networking via collaborations with academia and industries, adaptability in research, and more. These skills will enrich my research competencies and contribute significantly to my career growth as a researcher.

Keywords: single atom catalysis heterogeneous catalysis flow chemistry
Nurturing Environment - BioPrinting Human Renal Organ Networks (NEPHRON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2374988.0
EU funding (EUR): 2374988.0
Participants: 1
Project status: SIGNED

Chronic kidney disease (CKD) results in loss of kidney function in patients, ultimately requiring organ transplant. Critical organ shortage and organ rejection after transplant make extended dialysis inevitable and the only therapy available. To exacerbate this problem, the incidence of CKD is increasing worldwide, with >14% of the general population affected. Hence, there is an urgent need for novel therapies. Induced pluripotent stem cells have been used to create kidney organoids representing early renal development stages. These organoids might be a suitable therapy in the future but fundamental challenges to achieve late stages of physiologically relevant maturation and function need to be addressed. The lack of vasculature and collection duct systems limits the viability and filtrate removal. To overcome this challenge, I aim to develop a novel, mature in vitro kidney model by exploiting different bioprinting technologies combined with organoid knowledge. This solution will include a bioengineered kidney extracellular (ECM) microenvironment, a vascularized network and a collecting duct system. I hypothesize that the strategic combinations of different bioprinting techniques will allow the development of key structures such as vasculature, essential for promoting maturation of the in vitro model, and a collecting duct for filtrate collection with an expected increase in function resembling the organ. Finally, the combination of the different modules on a microfluidic platform will allow the accurate control of the organoid perfusion and long-term cultures. NEPHRON will allow further knowledge on bioprinting functional kidney units while providing scientists an improved in vitro model to study development, disease and regeneration of the kidney. This knowledge can lead ultimately to alternative therapies and give initial indications on the future possibility of bioprinting a full functional organ.
Promoting innovation for sustainable sorting and recycling of dedicated bio-based plastics (PROSPER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Belgium,Italy,Netherlands,Spain,Germany,France
Call: Recycling bio-based plastics increasing sorting and recycled content (upcycling). (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 10196836.25
EU funding (EUR): 7498855.25
Participants: 20
Project status: SIGNED

Bio-based plastics are now seen as an eco-friendly substitute for traditional fossil-based plastics. Interestingly, aside from their environmentally friendly origins and in some cases, their biodegradability, bio-based plastics present a promising market potential for recycling, particularly through chemical depolymerisation. Nevertheless, before recycling, bio-based plastics must first be separated and isolated from other packaging materials. Achieving effective sorting of bio-based plastics presents a challenge in the market, as bio-based plastics require scale to be sorted and to form a circular economy. Yet, they also need circularity as a sustainability selling point to boost their sales. The PROSPER project brings together three bio-based plastic producers (including PLA and AAPE-blend producers), a major brand owner, an EPR scheme/PRO participant, a supplier of AI-sorting technology, a sorting testing center, four waste management companies, a municipality and a specialised consultant. It is supported by the scientific expertise of three research institutions and universities, as well as a policy-oriented non-profit organisation. The project offers a comprehensive approach by developing policy interventions, EPR fee scenarios and quantifying recycling rates and cost benefits associated with these scenarios. It also focuses on demonstrating technical advancements in sorting and recycling at industrial scale inside four real waste management companies. PROSPER will also evaluate the market potential for recycled bio-based plastic products through consumer studies, engagement with companies and PROs, while also assessing the Life Cycle, Social Life Cycle, material circularity indicators and economic business models. The institutionalisation of a system change by the different stakeholders in the bio-based plastics value chain will be crucial in achieving circularity, improving environmental performance and fostering positive impacts in the bio-based economy.

Keywords: bio based plastic,recycling,sorting,closed loop recycling,epr,demonstration,ai