Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterisation of PI3K isoform roles in pancreatic cancerogenesis (PACA/PI3K)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-04-01
End date: 2014-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference. Mammals have multiple PI3K isoforms. During my UK post-doctoral training funded by EIF, I have created and characterized new mouse models targeting one isoform of PI3K, p110beta, which physiological role was unknown. Isoform-specificity of p110beta in cell signalling, and in physiology, in particular in angiogenesis, was investigated using these gene-targeted mice. These results led to a revisited classification of PI3Ks. PI3K signalling is altered (constitutively active) and correlated with a poor pronostic in pancreatic adenocarcinoma. Pancreatic adenocarcinoma is one of the most lethal cancers and no chemotherapeutic treatment is currently available for this type of cancer. In this proposal, I will study the isoform-specific role of the signalling enzymes PI3Ks using new unique mouse models created and characterised during my post-doc in which each isoform of PI3K is genetically inactivated. While PI3K inhibitors are already tested in clinical trials for cancer applications, the implication of the different isoforms of PI3K in cancer is still unclear and intensely debated. This project targets to increase the understanding of the complex relationship within the different isoforms of PI3K in cancer cell signalling in vivo, in order to better target and prevent secondary effects in this clinical context. This re-integration period in Toulouse, France, will allow me to be familiarized with mouse pancreatic models used by the Host Group. Having secured a permanent position as a junior scientist in the Host team, I aim to integrate myself in this new cancer research environment and to develop my independence inside this group by implementing this project on a “hot” topic in cancer research.

Keywords: signal transduction,mouse models,pi 3-kinase,cancer,pancreas,gene-targeted mice,disease,isoform,tumourigenesis,cell biology,laboratory animal science,gastroenterology,anticancer therapy
Locus specificity of immunoglobulin gene diversification (DIVAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 339512.5
EU funding (EUR): 339512.5
Participants: 1
Project status: CLOSED

B cells distinguish themselves from all other cells, as they diversify their immunoglobulin (Ig) genes by hypermutation, gene conversion and switch recombination. All three processes required the expression of Activation Induced cytidine Deaminase (AID). The project aims to resolve the long-standing question why hypermutations are targeted almost exclusively to the Ig loci. Using the chicken B cell line DT40 as a model the fellow's laboratory previously identified a 10 kb cis-acting regulatory sequence (DIVAC) within the Ig light chain locus which activates hypermutation. The first goal will be to define the functionally relevant parts and sequence motifs of DIVAC and to determine their optimal arrangement. The next objective will be to identify DIVAC binding factors which may interact with AID and recruit it to the Ig loci. The last goal will be to understand how the DIVAC binding factors coordinate the association of AID with the neighboring transcribed sequence. This project will be developed in one of the best molecular immunology labs in Yale University and then transferred to the Centre for Chromosome Biology at the National University of Ireland, Galway. The outgoing host David Schatz has a long and excellent track record studying Ig gene diversification in mice and humans. The return host Noel Lowndes has extensive expertise in the analysis of protein-protein as well as DNA-protein interactions needed at the later stages of the project. The fellowship will allow the fellow to resume his career as an experimental scientist after a paternity leave and acquire valuable new knowledge in bioinformatics, comparative biology and protein chemistry. He will also gain complementary skills by participating in student teaching programs. The European community will benefit from the transfer of an excellent and competitive project , the establishment of long-term international collaborations and the eventual re-opening of the fellow's laboratory in Europe.

Keywords: natural sciences,genetics,immunology,molecular biology,immunoglobulin gene,aid,somatic hypermutation,gene conversion,b cell,dt40,dna repair,transcription,mutagenesis,locus control
CLEaner OPerations Attained Through Radars' Advance (CLEOPATRA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Italy,France,Netherlands
Call:  (SP1-JTI-CS-2010-03, 2010)
Start date: 2011-04-11
End date: 2013-07-10
Duration (months): 27.0
Total project cost (EUR): 744357.0
EU funding (EUR): 447644.0
Participants: 4
Project status: CLOSED

CLEOPATRA project aims at developing a SW procedure able to simulate relevant weather phenomena as they appear to airborne weather radars, starting from a high level description of the weather phenomenon (scenario), up to obtain the polarimetric I/Q signals at radar output. Such data have to be used as input to processing system simulation software (outside the scope of the present work) to be developed as test bench to compare the performances of new improved weather detection algorithms with older ones. The following main issues will be considered:  Meteorological modelling (scenario definition)  Electromagnetic modelling (backscattering from hydrometeors)  Weather radar modelling (including clutter, antenna effects etc) having in mind the goal of developing a new class of simulators, able to combine the description of the meteorological scenario at mesoscale level (typical of the environment simulators) with the capability of generating accurate time series of raw signals (typical of the microphysical simulators), while keeping complexity and computational effort manageable. The procedure shall be “validated” by referring at experimental data coming from a ground based weather radar.

Keywords: weather radar,modelling,electromagnetic,meteorogical scenarios
Development of a Closed Loop Flow Control Algorithm for Wing Trailing Edge Flow Control Including Experimental Validation in Two Low Speed Wind Tunnel Tests (CLFCWTE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2010-03, 2010)
Start date: 2011-06-01
End date: 2013-12-31
Duration (months): 31.0
Total project cost (EUR): 559191.0
EU funding (EUR): 419393.0
Participants: 1
Project status: CLOSED

Smart Fixed Wing Aircraft (SFWA) aims to develop and test passive and active flow control technologies to improve the high lift performance of a wing. The purpose of this research is to develop and demonstrate a closed loop flow control to minimise the separation on a trailing-edge flap. The active flow control will improve the aerodynamic performance by delaying the trailing-edge separation on a single element trailing-edge flap. The flow control will be pulsed blowing applied near the leading-edge region of the flap. The pulsed blowing will be through spanwise segmented slots. A closed loop flow control system will be designed to demonstrate flow control on a mid-scale wind tunnel model. The Topic Description calls for two directions of closed loop flow control methods. The first is a pre-modelled approach which would allow the calibrating of the algorithm. This algorithm development will be devoted for future use in flight test activities. The second method is an adaptive algorithm, which will be adjusted by a “learning-by-doing” system. This approach will be demonstrated in mid-scale wind tunnel tests.

Keywords: active flow control,high lift devices,aerodynamics,separation delay,blowing,closed loop flow control
Wireless/Integrated Strain Monitoring and Simulation System (WISMOS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Greece,Italy,Netherlands
Call:  (SP1-JTI-CS-2010-03, 2010)
Start date: 2011-02-01
End date: 2013-01-31
Duration (months): 24.0
Total project cost (EUR): 251960.0
EU funding (EUR): 183125.0
Participants: 3
Project status: CLOSED

This proposal addresses the development and real time test validation of an integrated hardware and software environment that will be able to measure real-time in-situ strain and deformation fields using a state-of-the-art wireless sensor system to enhance structural durability and damage tolerance (D&DT), reliability via real-time structural health monitoring (SHM) for sensorized aerospace structures. The tool will be a vital added extension of existing suite of structural health monitoring (SHM) and diagnostic prognostic system (DPS). The goal of the extended SHM-DPS is to apply a multi-scale nonlinear physics-based finite element analyses (FEA) to the 'as-is' structural configuration to determine multi-site damage evolution, residual strength, remaining service life, and future inspection intervals and procedures. The proposed approach will enable active monitoring of aerospace structural component performance and realization of DPS-based conditioned based maintenance. Software enhancements will incorporate information from a distributed sensor network system. As case study DPS application a realistic composite stiffened panel representative of fuselage/wing components will be selected. Two stiffened panels will be manufactured and instrumented; a) embedded internally between composite layers, and b) surface mounted with an optimized distribution of wireless sensors. The panels will be tested in compression following low-velocity impact. The sensor system output will be integrated with a finite element analysis (FEA) tool to determine the multi-site damage locations, and associated failure mechanisms, residual strength, remaining service life, and future inspection interval. The FEA will utilize the web based GENOA commercial software capable of evaluating both metallic and advanced composite structural panels under service loading conditions. The proposal will utilize a building block validation strategy, and real-time structural health monitoring system.

Keywords: wireless strain gauges,genoa,in-situ measurement,damage localisation,failure mechanism determination,residual strength calculation,health monitoring
Model Theory and Algebraic Analysis (MODALAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 152449.6
EU funding (EUR): 152449.6
Participants: 1
Project status: CLOSED

The researcher Dr. Luca Prelli will carry out the interdisciplinary project "MODALAN": Model Theory and Algebraic Analysis at the University of Lisbon, Portugal. At the host institution there is a scientific expertise that suits the researcher's needs excellently since it houses young and active researchers in model theory plus it is home to some of the best specialists in algebraic analysis. A contact between these two fields of mathematics is very rare and, at the present point of his career, for the applicant it would be essential to acquire new cutting-edge skills. Within a period of 24 months, the aim of this research project is to develop the applicant's knowledge in algebraic analysis and geometry and acquire new skills in two different subjects: the algebraic study of PDE on one side and the analytical model theory on the other. The nature of this proposal is strongly multidisciplinary since it involves different branches of mathematics as algebra, analysis, geometry and logic. In particular, concerning 1), we would like to extend classical methods of algebraic analysis and apply these new techniques to approach Cauchy problems with growth conditions. Concerning 2), we intend to contribute to the development of the study of o- minimal sheaf cohomology in order to obtain a general solution of the Pillay conjecture. The applicant has already acquired professional maturity, independence and international visibility. He spent various research periods abroad, established collaborations and made scientific publications with other foreign researchers. The action can make a significant contribution to the applicant's professional maturity. He will be integrated into a high level foreign university structure and professionally recognized in another national context while having the possibility of expanding his knowledge and research qualities. In the long term perspective, this will support the applicant in furthering his academic career at an international level.

Keywords: algebraic geometry,differential equations,model theory,algebraic analysis,d-modules,sheaves on grothendieck topologies
The dark sector in cosmology and impact on present and future generation experiments. (DEMO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-02-01
End date: 2014-01-31
Duration (months): 24.0
Total project cost (EUR): 170401.6
EU funding (EUR): 170401.6
Participants: 1
Project status: CLOSED

Cosmology has seen the growth of an enthusiastic interest in the Dark Universe we live in. Observations show that ordinary matter is only a small fraction of the total energy in the Universe. The rest is in the form of Dark Matter and Dark Energy. They both emit no light: Dark Matter feels gravitational attraction and allows galaxies to form; Dark Energy contrasts gravity and makes the Universe expand faster and faster. My research project will identify the observable effects that indicate dynamics in the Dark Energy component, disentangling it from a cosmological constant. To do this I will investigate interactions among Dark Energy and other species in the Universe. Furthermore, I will consider the case in which General Relativity itself is modified. I will predict effects on cosmic microwave background and structure formation. Halo profiles, supercluster structures, the Integrated Sachs-Wolfe effect are some of the features affected by an interaction that can make Dark Energy dynamics observable. I will compare my findings to experiments like PLANCK and EUCLID. The PLANCK satellite is now observing the cosmic microwave background with precision higher than ever. As part of the PLANCK collaboration, I can analyze the data and extract from them information on cosmology and Dark Energy. EUCLID has reached the final selection stages of the ESA Cosmic Vision Program: its proposal is based on a satellite which will observe galaxies at distances higher than ever. I will forecast the ability of EUCLID to investigate Dark Energy and modified gravity through effects on structure formation. The research in Geneva will allow me to investigate the impact of the Large Hadron Collider findings right at the time when LHC results will be made available. The discovery of an interaction would be inestimable for cosmology, providing a specific tool to disentangle dynamical dark energy from a cosmological constant, with a profound impact on our knowledge of the universe.

Keywords: cosmology,astrophysics,general relativity,dark energy,dark matter,cosmic microwave background,structure formation,gravity
International Alliances for Preventive Diplomacy and Conflict Resolution: Peace Negotiations and Implemented Resilience Strategies (PEACE NEGOTIATIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-07-01
End date: 2014-06-30
Duration (months): 36.0
Total project cost (EUR): 328852.5
EU funding (EUR): 328852.5
Participants: 1
Project status: CLOSED

Global challenges must be met with an emphasis on peace and negotiation, in harmony with other actors, through alliances and international consensus. The literature on psychology applied to international negotiation has been progressing at a theoretical level, but we know much less about how to master interacting cognitive and affective processes to shape judgements and decisions. Our psychological cognitive-motivational approach may help to widening the understanding and improvement of relational abilities reducing potential risks of negotiations failures due to psychological barriers. Our approach could provoke positive operational consequences due to its multidisciplinary perspective in integrating specific political and socio-psychological knowledge and techniques applied to structured training contexts for negotiators and mediators. To us, it is important how people negotiate: as such our approach is unequivocally concerned with issues of process. It is important, for instance, together with cognitive processes to study and research on the effects of specific emotional processes in games and negotiations; or the effects of emotion suppression Vs expression in negotiation; or the development of resilience tools in people in the face of stress. As matter of fact, this research project will foresee two interrelated and interdependent researches with USA and European Union (EU) negotiators: a) on negotiation styles, and b) on human characteristics of negotiators. Our goal is not to proclaim “winners” and “losers” in a forecasting contest but rather to study how highly trained professionals and diplomats reason and feel about complex real-world processes under conditions of stress and uncertainty. Moreover, to try to understand, a little bit more European and American diplomat thinking in its evolution, to provide a benchmark for future comparison and discussion with practical and operational implications for the realm of International conflict resolution

Keywords: social sciences,psychology,conflict resolution,international negotiation
Parameterization of computational domains for isogeometric analysis (PARADISE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 175406.4
EU funding (EUR): 175406.4
Participants: 1
Project status: CLOSED

Isogeometric analysis (IA), which was introduced in 2005 by Tom Hughes et al., is a novel technique for numerical simulation which uses the same spaces of functions for the representation of the geometry and for the numerical simulation. It has the potential of closing the gap between numerical simulation and computer aided design, which is caused by the different representations of geometry (piecewise linear vs. rational splines = NURBS). This gap is currently a bottleneck in the design process, since the design and the numerical simulation phase cannot be connected in a seamless fashion, but only through time-consuming conversion processes. The application of IA leads to new challenging problems for geometric design, which are related to the representation of computational domains by NURBS parameterizations. The project will address some of them. More precisely, it will discuss computational methods for generating NURBS parameterizations for several classes of computational domains, such as CSG models, general CAD models, and domains obtained from medical data. It will also analyze the quality of these parameterizations with respect to the distribution of singularities and with respect to the distortion which is introduced by the parameterization. Additional points of interest are the construction of locally refinable spaces of test functions for IA, which are compatible with NURBS parameterizations and support both h-refinement (knot insertion) and p-refinement (degree elevation), domain decomposition techniques and design optimization. These three topics will be analyzed in close connection to related applications to numerical optimization and to shape optimization. The execution of the project requires the combination of knowledge available at the host institution with the expertise of some of its European partners, as well as the profound education of the fellow in Computer Science and Applied Mathematics.

Keywords: computer aided design,numerical simulation,isogeometric analysis,domain parameterization,parameterization quality,mesh refinement,hierarchical splines,shape and design optimization