Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Concrete micromolds for microinjection molding (CONMIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-07-01
End date: 2017-06-30
Duration (months): 12.0
Total project cost (EUR): 149212.5
EU funding (EUR): 149212.5
Participants: 1
Project status: CLOSED

Microinjection molding is the current standard technology for the production of microcomponents. There is an increasing demand for microcomponents with feature sizes down to micrometers due to a general trend towards miniaturization in the medical and automotive industry. The main problem to meet this demand is the considerable fix-cost of the micromolds (microstructured injection tool inserts). Currently, the methods for their fabrication are lithography-based LIGA-techniques, electrical discharge machining (EDM), or precision laser ablation with high capital and maintenance costs. Our goal is the development and commercialization of inorganic composite micromolds, which can be produced at significantly reduced costs, thus making microinjection molding more profitable and variable. We found that inorganic composites are surprisingly versatile material for this purpose. The amazing feature of these composite micromolds is their extremely smooth surface having sub-micron roughness, an exact replication of even micrometer size features, and their excellent stability. Lower fix costs for such micromolds allow microinjection molding also of smaller numbers of microparts for special demands, e.g. for medical applications, thus opening new markets for microinjection molding. The proposed project aims to bring this idea to the proof-of-concept level by demonstrating a inorganic composite micromold that can be used in commercial microinjection molding equipment for the production of microcomponents. In parallel, we will also develop our future technical and intellectual property rights strategy, explore the market potential and secure potential customers. We finally intend to launch a company to develop the product and bring it to the market.

Keywords: concrete,micromold,microinjection molding,microcomponents
Microscopic Origins of Fracture Toughness (microKIc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany,France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2023-04-30
Duration (months): 72.0
Total project cost (EUR): 1996570.0
EU funding (EUR): 656738.25
Participants: 3
Project status: SIGNED

The resistance to crack propagation is undoubtedly one of the most important properties of structural materials. However, our current mechanistic understanding of the fracture processes in typical semi-brittle materials like steels, refractory metals or semiconductors is not sufficiently advanced to predict the fracture toughness KIc and its dependence on the microstructure, temperature and strain rate. Therefore, KIc is commonly regarded as a phenomenological material parameter for fracture mechanics models that require experimental calibration. The aim of microKIc is to study fracture in model materials in order to gain a detailed understanding of the microscopic crack-tip processes during fracture initiation, propagation and arrest, and to systematically study the interactions of cracks with constituents of the microstructure like dislocations, voids, precipitates and grain boundaries. To this end, we will perform fully 3D, large-scale atomistic simulations on cracks in bcc-based materials (W, NiAl) with varying crack orientation, crack front quality, and in the presence of dislocations and microstructural obstacles. The obtained criteria for crack advance and dislocation nucleation at crack tips will be implemented in a coupled finite element - discrete dislocation dynamics code, which will allow for the first time a fully 3D study of fracture and crack-tip plasticity at the mesoscale. The simulations will be compared to in-situ micro-mechanical tests on well-characterized fracture specimens produced by focused ion beam milling. The ultimate goal of microKIc is to use this experimentally validated multiscale modelling framework to develop a microstructure-sensitive, physics-based micromechanical model of the fracture toughness, which will be tested against macroscopic fracture experiments. Such predictive models are crucial for the development of new failure-resistant materials and for improved design guidelines for safety-relevant structures and components.

Keywords: fracture,microstructure property relationships,multiscale modelling,atomistic simulation,discrete dislocation dynamics,micromechanical testing,micromechancial model,brittle ductile,transition
A test for predicting the efficacy of common platinum drugs enabling personalized chemotherapy for bladder cancer patients. (platinDx)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom,United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Platinum-based chemotherapy is the primary therapeutic intervention for over 500,000 patients per year in the EU. Although some patients are cured by this type of chemotherapy, as many as 75% of lung cancer patients and 60% of bladder cancer patients show no benefit and could be more appropriately given alternative treatments, and therefore over €4bn annually is wasted on unnecessary treatments. There is a need for a rapid, accurate test to distinguish those patients who are likely to respond to chemotherapy and those who are not. Accelerated Medical Diagnostics aim to personalise chemotherapy for cancer patients through their own developed PlatinDx assay, which can be used to identify those patients which are appropriate for platinum-based chemotherapy. Cancer patients are given a microdose (1% of the therapeutic dose) of a platinum-based drug, followed by quantitation of drug-DNA adducts in biopsy tissye using accelerator mass spectrometry (AMS). Levels of drug-DNA damage are measured by AMS in white blood cells and tumor biopsy tissue, which are used as a predictor of therapeutic response. Within the innovation project Accelerated Medical Diagnoistics intend to: gain medical certification within the EU; run a scaled up clinical trial to gain significant results; and adress the EU market and launch their service in the EU.

Keywords: predictive test for platinum based cancer diagnostics
Risk Stratification for Sudden Cardiac Death (RISTRAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Sudden cardiac death (SCD) is a leading cause of total and cardiovascular mortality. Ventricular fibrillation (VF) is the most common arrhythmia causing SCD. In young individuals, SCD occurs primarily in the setting of rare cardiac disorders generally considered as Mendelian diseases. Among these are the primary electrical disorders associating lethal arrhythmias such as VF. These disorders are highly amenable to genetic studies since they manifest clinically with specific features on the electrocardiogram. As of today, the large gap in our knowledge concerning the determinants of VF at the genetic and molecular level hinders breakthroughs in the development of risk stratification and preventive strategies. As a model of a primary rhythm disorder, Brugada syndrome (BrS may be considered as 'sensitized model' for SCD and be relevant to the broad problem of SCD in the setting of common cardiac pathologies. The aim of this project is to prpose a translational study, combining genome wide association studies in the largest biobank of patients with cardiac arrhythmia ever collected, genotype-phenotype studies for clinical relevance/use and functional characterization for novel genes uncovered. The overarching aim of the study is to decipher the genetic model of the BrS by identifying novel genetic factors that modulate risk for SCD. We also believe that the impact of this project, although focused on a rare disease such as Brs, will be much broader in the field of cardiac arrhythmias and more generally for SCD.

Keywords: genome wide association study,sudden cardiac death,brugada syndrome
Revolutionary Design of Spacecraft through Holistic Integration of Future Technologies (ReDSHIFT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Spain,Spain,Italy,Greece,United Kingdom,Luxembourg,United Kingdom,United Kingdom
Call: Passive means to reduce the impact of Space Debris (H2020-PROTEC-2015, 2015)
Start date: 2016-01-01
End date: 2019-03-31
Duration (months): 39.0
Total project cost (EUR): 3230295.0
EU funding (EUR): 3230294.0
Participants: 13
Project status: CLOSED

ReDSHIFT will address barriers to compliance for spacecraft manufacturers and operators presented now and in the future by requirements and technologies for de-orbiting and disposal of space objects. This will be achieved through a holistic approach that considers from the outset opposing and challenging constraints for the safety of the human population when these objects re-enter the atmosphere, designed for demise, and for their survivability in the harsh space environment while on orbit. Ensuring robustness into the future, ReDSHIFT will take advantage of disruptive opportunities offered by 3D printing to develop highly innovative, low-cost spacecraft solutions, exploiting synergies with electric propulsion, atmospheric and solar radiation pressure drag, and astro-dynamical highways, to meet de-orbit and disposal needs, but which are also designed for demise. Inherent to these solutions will be structures to enhance spacecraft protection, by fracture along intended breakup planes, and re-entry demise characteristics. These structures will be subjected to functional tests as well as specific hypervelocity impact tests and material demise wind tunnel tests to demonstrate the capabilities of the 3D printed structures. At the same time, novel and complex technical, economic and legal issues of adapting the technologies to different vehicles, and implementing them widely across low Earth orbit will be tackled through the development of a hierarchical, web-based tool aimed at a variety of space actors. This will provide a complete debris mitigation analysis of a mission, using existing debris evolution models and lessons learned from theoretical and experimental work. It will output safe, scalable and cost-effective satellite and mission designs in response to operational constraints. Through its activities, ReDSHIFT will recommend new space debris mitigation guidelines taking into account novel spacecraft designs, materials, manufacturing and mission solutions.

Keywords: space debris mitigation,advanced astrodynamics,spacecraft design,3d printing,rapid prototyping,design for demise
Representative Government through Democratic Governance (REPGOV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Spain
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2477902.5
EU funding (EUR): 2477902.5
Participants: 1
Project status: SIGNED

How does representative government function when administrative policymaking has the authority to reshape democracy? The discretion that modern governments give to unelected officials, who have policy preferences themselves, not only captures the means for implementing policies, but also the authority to make tradeoffs among important democratic values to promote the outcomes they desire. REPGOV aims at exploring how governance structures shape the way officials make democratic value tradeoffs. REPGOV’s mixed-method design, scale, and scope have the potential to recast the study of public administration into more richly democratic terms, and to make unique and significant contributions to the study of political philosophy, institutions and behavior. The project has four main objectives. First, it will develop a unified theoretical approach grounded firmly political science and allied disciplines that explains why and how governance structures reinforce the values of the representative government by shaping officials’ belief systems. Second, the project grounds theory into practice through rigorous qualitative research into the way that formal and informal institutions shape belief systems. Third, through state-of-the-art machine learning methods, REPGOV will construct an important database that captures democratic values in laws and regulations and conduct large-scale observational tests of the relationship between institutional politics and the democratic values in delegated authority. Fourth, through survey and laboratory experiments, REPGOV will examine the effect of formal and informal institutions on officials’ democratic beliefs

Keywords: public administration,bureaucratic accountability,public sector reform,political institutions,political theory,representative government
The Neurobiology of Social Context-Dependent Stress Responses (NotSOSTRESSED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2025-01-29
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Sociability –an individual's tendency to engage in group interactions– is a fundamental property of life. Recently, sociability has been identified as a strong mortality predictor in humans. Although affecting health, we lack an understanding of the biological mechanisms underlying sociability. I here propose that the presence of others modulates an individual's response to an environmental stressor. Being evolutionary conserved, I will investigate the sociability neurocircuitry in the model system Drosophila melanogaster. I will tackle this by focussing on 4 objectives: WP1) Delineation of sensory cues and receptors modulating social context-dependent stress responses through behavioural analysis of candidate receptor gene mutations, targeted RNAi and pheromonal bioassays, WP2) Identification of neurons processing sensory information relevant to stress by functional investigation of the neurocircuitry connecting mechanosensory, pheromonal and temperature stress sensing through connectome, trans-Tango and optogenetic approaches, WP3) Mapping of higher brain stress-responsive foci integrating stressor and social information through Ca2+-imaging, WP4) Dissection of the hormonal pathway effectuating social-regulated stress responses via tissue-targeted genetic knockdown and overexpression of pathway components and stress response assays. Addressing key questions relevant to human health will bring scientific Excellence and Innovative advances to the current knowledge gap in Behavioural, Neuro & translational sciences which will be communicated to the scientific and general public. The fellowship will enhance my personal research potential and career perspectives by acquiring novel scientific and transferable skills, training of myself and others and increase my international mobility, network and interdisciplinary transfer though secondments. This proposal is in line with the Horizon2020 Responsible research & innovation objective 'Science with and for Society’.

Keywords: drosophila,social behaviour,stress,neurobiology,sexual dimorphism,neuronal circuits
Comprehensive data-driven Risk and Threat Assessment Methods for the Early and Reliable Identification, Validation and Analysis of migration-related risks (CRiTERIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Research and Innovation actions
Countries involved: Estonia,Austria,Italy,Germany,Cyprus,Malta,Greece,Croatia,Romania,Sweden,Switzerland,Greece,Netherlands
Call: Human factors, and social, societal, and organisational aspects of border and external security (H2020-SU-SEC-2020, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 4890177.5
EU funding (EUR): 4890177.5
Participants: 15
Project status: SIGNED

EU borders are constantly faced with a multiplicity of challenges, from increased waves of illegal migration to human trafficking, document fraud, terrorism, smuggling, and public health threats. In the CRiTERIA project we will develop a novel risk analysis methodology, which is, on the one hand, clearly rooted and builds upon existing methodology such as CIRAM and, on the other hand introduces novel more complex and effective indicators, which overcome important limitations of existing models. Such extended risk and vulnerability analysis methodology has to be backed by effective intelligent analysis technology. Building upon existing text, media, data and network analysis technology, in CRiTERIA, we will develop and evaluate advanced analysis technologies and tools that are tailored to the new comprehensive threat indicators of the CRiTERIA methodology. Special focus will be put to the consideration of the role of narratives, events, attitudes, and to the vulnerability of borders and humans as well as on providing semi-automatic tools and methods for risk-related evidence validation and explanation, for identifying risk propagation and interlinking, thus supporting decision processes in risk analysis in an innovative way. When developing this holistic CRiTERIA risk and vulnerability analysis framework for border agencies ethical, legal and societal aspects will be considered from the very beginning. The methodology will be developed in close collaboration with practitioners from border agencies, which will also validate the developed methods and technologies in piloting activities. For achieving its goals CRiTERIA brings together an interdisciplinary team of experts including researchers in the fields of security and risk analysis, in the field of data and media analysis and in the field of ethics, law and societal aspects, as well as border agencies, NGOs and companies.
An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment (in3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Italy,Italy,Austria,Switzerland,Belgium,Slovenia,Switzerland,Hungary,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3860843.4
EU funding (EUR): 3860843.4
Participants: 19
Project status: CLOSED

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.

Keywords: in vitro,in silico,interdisciplinary,safety,toxicity,adverse outcome pathways,ipsc,animal free,nanomaterial,toxins,chemicals,risk assessment