Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using Copernicus Earth Observation radar data to disrupt Precision Agriculture (AgroRadar)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Portugal
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Precision Agriculture (PA) has been enabled by satellite imagery and provide disruptive new tools and decision support for farmers. However, we have identified that satellite optical data, currently being used by the best PA companies around the world, is not enough to obtain the best results. We have developed our proprietary AgroRadar algorithms and data models that process Copernicus EO Synthetic Aperture Radar (SAR) data (Sentinel 1A and 1B), therefore obtaining more precise and detailed information than any other PA company in the world, in an affordable, automated way, and our objective is to deploy a scalable PA service based on Copernicus Earth Observation data (using optical and SAR imagery) available to clients worldwide, tailored for diverse types of crops, forests and livestock explorations. SAR imagery has the competitive advantage to not being affected by clouds or fog, making it possible for our report to make full use of the 5-day imaging time frame made available by Copernicus Sentinel Satellites almost worldwide (optical images can have up to 75% less availability and therefore are useless for creating on-time weekly reports for our end-users). The global PA market is estimated to reach €7 billion by 2022 with a CAGR of 15% between 2016 and 2022. USA market is currently the more mature, but EU is currently valued at 600M€ and growing at a fast pace. Our end users are farmers (with pricing options for small and large scale operations), insurance companies and banks (asset owners) and also governmental agencies responsible for forests, large water body management and subsidies verification (i.e. we are the only company providing a solution for large-scale forest fire risk charts based on sub-canopy detection of biomass). We have created AgroInsider to provide PA services in early 2016, and so far our expert team of 5 employees (growing rapidly) has generated a turnover of 160.000€, with clients in Portugal, Spain and Brazil.

Keywords: copernicus,earth observation,synthetic aperture radar sar,sentinel 1a and 1b,big data,precision agriculture,permanent availability,crop data models,sub canopy analysis,forest biomass
Historical dynamics of coastal and marine ecosystem services. (MarHIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project addresses the globally important problem of how we sustain coastal and marine ecosystem services. Ecosystem services, the benefits humans gain from ecosystems, are fundamental to societal well-being, but marine ecosystem services research lags behind its terrestrial counterpart, while historical dynamics are frequently overlooked. Without understanding long-term dynamics in marine ecosystem services, we risk missing declines in services that may affect societal well-being. This includes our understanding of interactions among services, the role of societal feedbacks on service provision and prediction of social-ecological tipping points. This project aims to interrogate historical data to reveal the dynamics of coastal marine ecosystem services over decadal to centennial timescales. By integrating interdisciplinary sources and methodologies from archaeology, history and ecology disciplines, the project will examine dynamics and social-ecological feedbacks in provisioning, regulating and cultural coastal marine ecosystem services. Under the mentorship of Profs Godley and Bateman, and by collaborating with University of Exeter researchers from a range of disciplinary backgrounds, I will be able to expand my research horizons and learn new interdisciplinary skills. This will not only enable me to strengthen my CV, placing me in a strong position to achieve my career goals of becoming a leading researcher within the European community, it will contribute new interdisciplinary research to the ecosystem services and ecology fields, thus improving our understanding of the links between marine ecosystems and societal well-being, a critical knowledge gap of global relevance. These findings will also produce baseline data and methods that will be readily translatable to policy (such as the European Commission’s Blue Growth Strategy) and able to inform sustainable resource management goals, with benefits for both society and the environment.

Keywords: ecological change,ecosystem dynamics,environmental history,historical ecology,marine social ecological systems,interviews,time series,social change,cultural values
Disruptive portable device for pre-screening of Persistent Organic Pollutants –POPs- in food products and water (NanoScreen)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Slovakia
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-06-01
End date: 2019-11-30
Duration (months): 30.0
Total project cost (EUR): 1745335.0
EU funding (EUR): 1221734.5
Participants: 1
Project status: CLOSED

Persistent organic pollutants (POPs) are organic compounds produced by human action resistant to environmental degradation and whose bioaccumulative capacity and toxicity can cause harmful health effects e.g. cancer. Hence, they have become global threats for human and environment. The most extended analytic methods used nowadays for detecting POPs are gas chromatography and/or mass spectroscopy to separate and identify them. These methods are expensive -€1,000/sample-, time-consuming -24h-, require a laborious sample preparation and a well-equipped laboratory. Consequently, there is a great demand to increase the number of water and food quality tests if available for a lower price and shorter time. SAFTRA PHOTONICS will bring to market NanoScreen - a portable nano-optical sensing chip for pre-screening purpose that detects food or water contamination by POPs. We will offer a rapid method (10 minutes) to detect the most important POPs (ppb) present in food products and water, carrying out an in-situ analysis for less than 100€ per sample. By putting NanoScreen solution into the the European, Japanese and USA market, in 2023 we expect to sale 55,000 chips with revenue of €4,800,000 (27% Y/Y growth) and ROI 3.25. This ensures sustainability of 37 new full time job positions at company. The project resubmission (13.61) reflects couple of great achievements of 2016: FS has elaborated in detail the NanoScreen business plan, the company has signed two investment agreements, three business partners and two distribution partners. Moreover, we have identified another two major replication opportunities of future joint ventures that can form a new business-industrial ecosystem for online nano-screening. The vision is to reach a unique one-box-system tailored for specific applications, e.g. security, agriculture and sport. The Phase 2 funding will help us to close the gap from design validation to industrial production and significantly shorten the market entry period.

Keywords: persistent organic pollutants,pesticides,analytic method,optical,pre screening,food analysis
AN APP TO HELP EUROPEAN COMPANIES TO RETAIN TALENT AND REDUCE JOB TURNOVER (Mob)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

To reach full productivity, a new employee typically takes from 8 to 12 months. Moreover, during his/her first 45 days, 20% of them decide to quit. Currently, approximately 75% of the companies worldwide have implemented an onboarding process investing an average of €5,380 per new hire. Manual delivering of onboarding information is not effective, but it is a heavy workload for HR managers and cannot be tracked; whereas available software in the market simply refer the employee to the intranet, which can consume up to 30% of the workday. MoB is an app dedicated to onboarding, with 22 modules delivering effective communication using: push-up notification, maps, surveys, virtual reality videos that allow the user to know the facilities and gamification, that increases the probability and an effective consumption of information. And which is more important, MoB is a non-intrusive, white-label and extremely intuitive app: it can be seamlessly integrated into companies’ existing IT systems, with perfect alignment with the corporate image, and easily configurable and manageable by non-IT experts. We have a SaaS business model that allows: 1) employees (end-users) to increase 23% their confidence and satisfaction and to have access to 5% more benefits. Moreover, MoB reduces 56.4% the time expended to achieve self efficiency and social integration. 2) companies with high employee turnover rates (customers) to increase 75% employees’ engagement, while reducing 31% employee turnover. With MoB, employees reach 97.7% productivity within the first 10 days. Through this project, we aim to boost Iphonedroid competitiveness by generating revenues of €23.5M by 2026 and increasing our workforce by at least 50%..

Keywords: human resources,on boarding,communication
Advancing cancer immunotherapy using natural killer cells for hematological and metastatic cancers (CINK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-15
End date: 2020-02-14
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The development of monoclonal antibodies (mAb) to target tumor cells has tremendously improve cancer immunotherapy and benefit the treatment of aggressive cancer such as some types of lymphomas, leukemias, multiple myeloma and metastatic cancers. One of the mechanisms of action is the induction of antibody-dependent cellular cytotoxicty (ADCC) through the activation of CD16 on NK cells after binding to the Fc portion of Ab-coated tumor cells. Therefore, strategies that combine NK cell activation and mAb therapy has been intensively explored. However, tumor heterogeneity and unstable expression of the targeted molecule in the tumor cells limits ADCC for mAb therapy resulting in cancer relapse. Furthermore, intrinsic NK immunregulatory mechanisms as well as NK-specific tumor evasion mechanisms have also negatively impacted the use of NK cell-based therapies. In this proposal we will explore the mechanisms involved in the reduced NK cell function (NCF) observed after ADCC and/or NK cell activation (NCA) in order to develop novel strategies to achieve a sustained and stronger NCF by combining stimulating signals with suppression of inhibitory signals such as costimulation via CD137 and IL12, or SHP1/2 blockade. We hypothesize that the adoptive transfer (AT) of NK cells expanded by this novel method will result in better anti-tumor responses after mAb therapy even in tumor cells that express limited amount of the target molecule and limiting consequently cancer relapse rates. Furthermore, due to the overall improvement on NCF, we expect that the combination of AT NK cells with hematopoietic stem cell transplantation (HSCT) will also increase anti-tumor responses; which efficacy up to date has shown to be rather limited. Given the versatility of our approach, this therapy can be used for the treatment of many cancers, but particularly hematological and metastatic cancers and potentially can be translated into the clinic in a short time frame.

Keywords: natural killer nk,cancer immunotherapy,hematopoietic stem cell transplantation hsct,cancer
e-Infrastructure Reflection Group Support Programme 5 (e-IRGSP5)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Germany,Bulgaria,Greece,Poland,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Support to policies and international cooperation for e-infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2016-12-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 989537.5
EU funding (EUR): 989537.5
Participants: 9
Project status: CLOSED

Project Summary The proposed project e-IRGSP5 is intended to provide support to the e-Infrastructure Reflection Group (e-IRG). The support activities include: • operation of the secretariat, e.g. organisation of events and provision of secretarial support to the e-IRG Chair and Executive Board; • provision of editorial support during the preparation of policy documents, input to the Commission and support e-IRG working groups and task forces; • liaison with e-IRG’s various stakeholders and maintain e-IRG’s social media channels • communication of e-IRG’s output; • operation of the external and internal e-IRG web presence; • collection and aggregation of policy information to enable assessment of e-infrastructures.

Keywords: e infrastructures,policy support,e irg,e infrastructure reflection group,european open science cloud,e infrastructure commons
Strategies to strengthen scientific excellence and innoVation capacIty for early diagnoSIs of gastrOintestinal caNcers (VISION)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Germany,Greece,Norway,Slovakia
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-06-30
Duration (months): 45.0
Total project cost (EUR): 787465.0
EU funding (EUR): 787465.0
Participants: 6
Project status: SIGNED

Slovakia belongs to countries with the highest incidence of colorectal and pancreatic cancer in Europe. Therefore, the main goal of the VISION proposal is to strengthen the scientific excellence and innovative capacity of Biomedicinske centrum Slovenskej akademie vied (BMC SAV), in early detection of gastrointestinal cancer (GI). Creation of a strategic partnership between the coordinator from widening county, BMC SAV and four internationally-recognized institutions, Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V. (FhG), Ramón y Cajal University Hospital Health Research Institute represented by Servicio Madrileno de Salud, (SERMAS), Ethniko Kai Kapodistriako Panepistimio Athinon (NKUA), and Norsk Institutt for Luftforskning Stiftelse (NILU) will enhance the credibility and recognition of BMC SAV in European research area. Transfer of knowledge and research ideas, sharing of know-how, expertise and best practices, together with the implementation of cutting edge-technologies, will contribute to the enhancement of high-quality translational cancer research at BMC SAV, particularly GI cancer. Collaboration and networking between VISION partners will accelerate the personal and professional development of early stage researchers and medical doctors, impact the rate of success in internationally competitive research funding and high-quality peer-reviewed publications. Involvement of VISION partners in mentoring and co-supervision of PhD will increase the quality of education at universities, mainly medical and natural science faculties. Moreover, regional and outreach activities supported by VISION will lead to enhanced public awareness of cancer and the importance of prevention.

Keywords: gastrointestinal cancer,early diagnosis,innovation,circulating tumor cells,microfluidic system
Soil bioremediation through flagellated bacteria: unravelling the mechanisms for enhancing bacterial tactic response (BIOTAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Bacterial dispersal is a key driver of pollutant turnover in contaminated soils. Flagellated bacteria able to degrade organic pollutants hold tactic responses to a variety of stimuli and reach pollutant hotspots, enhancing the access to poorly bioavailable carbon sources by steepening pollutant concentration gradients at interfaces. However, bacterial motility in porous media is often restricted due to high cell deposition rates and adhesion to soil particles, and in this sense, the modulating role of biological and chemical effectors is decisive. The aim of BIOTAC is the study of the mechanisms operating with flagellated bacteria for bioavailability enhancements and, therefore, a faster turnover of persistent organic pollutants in soils, including polycyclic aromatic hydrocarbons and a pesticide, lindane. We will study, at the microorganism scale, the role of bacterial taxis in chemical gradients (chemotaxis), as well as other tactic responses (repellence, surface taxis) in pollutant bioavailability, modelling and integrating them with other microbial adaptations (i.e. biofilm formation and the production of biosurfactants). We will develop strategies to improve bacterial transport to pollutant sources, using carefully selected biological and chemical effectors (respectively including, mycelial networks and organic compounds -root exudates, humic acids, and fertilizers), that favour flagella-mediated taxis, and co-mobilization of immotile degrading strains. The originality and innovation of the project lies on the macroscale projection of the microscale mechanisms underlying the access of self-propelled bacteria to limitedly available contaminants through an enhanced dispersal. Through experimental and modelling approaches, aiming at balancing biosorption and colloidal transport of the pollutants against biodegradation rates, the project will perform a risk and benefit analysis of the new bioremediation technology.

Keywords: chemotaxis,bacterial dispersal,bacterial motility,pollutant bioavailability,soil bioremediation
Extracellular vesicles as a tool to predict drug clearance and improve precision pharmacotherapy (EVPERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Drug transporters of the ATP-binding cassette (ABC) family (e.g., P-gp, MRP2 and BCRP) promote the intestinal, biliary and urinary excretion of a wide range of drugs and, thus, determine their bioavailability, therapeutic efficacy and toxicity. Transporter expression is highly variable between individuals and within the same individual. This may result in enormous differences in the plasma concentration of a drug, which for drugs with a narrow therapeutic index may result in life-threatening situations. Extraction of biopsies would be the only option to measure transporter expression in tissues and adapt the therapeutic strategy. However, this is not performed due to its invasive character. Extracellular vesicles (EVs) are nanoparticles released by all cells of the organism. Their cargo (proteins, RNA and lipids) is frequently a dynamic fingerprint of the cell. The presence of EVs from different tissues in blood and urine allows for an easy access. The aim of this project is to evaluate if the amount of ABC transporters in EVs from blood and urine can be used to specifically predict the transporter expression at the tissues of origin under basal and induced conditions, as well as to predict in vivo drug pharmacokinetics. Following work packages (WP) are proposed: WP I: EVs as dynamic surrogate for ABC expression in vitro and ex vivo. I.I. Validation of an analytical protocol for the quantification of ABC transporters in EVs, I.II. Correlation between ABC expression in biopsies and in EVs from the same specimens, I.III. Correlation between expression of ABCs in EVs from primary cells and the expression and activity of ABCs in the cells of origin under basal and induced conditions. WP II: EVs as biomarker for drug pharmacokinetics. II.I. Optimization of the immunopurification of circulating hepatic-, intestinal- and renal EVs, II.II. Correlation of ABC transporter expression in EVs with the pharmacokinetics of an ABC model substrate under basal and induced conditions.

Keywords: abc transporters,atp binding cassette,extracellular vesicles,drug clearance,bioavailability,p glycoprotein
Real Time, Automatic and Remote-activated Sampling System for industrial odor emissions compliant with the European Standard EN 13725 (ODORPREP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LabSevice is a company that provides analytical solutions in the area of environment, food industry and polymer characterization. We have already developed a prototype of OdorPrep, which will be the first automatic and remote sampling system for odor emissions in accordance with the EN 13725 Quality Air Standard. Thus the objective of this project is the full industrial development of the current OdorPrep prototype for industry uptake as part of an odor emission management and control system in accordance to legislation. That includes the development of the final product, upgrading, controls and certifications and patent protection. Odor emissions are an environmental pollution problem in Europe, being at the top of the list of air pollution complaints . Odor emissions occur during the operation of industrial sites (livestock farms, composting sites, landfills, refineries, etc.) which are regulated under different laws in Europe such as the Environmental Protection Act in the UK, or the Federal Emmission Control Act in Germany .

Keywords: odor emission,air pollution