Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimising a High Efficacy Plasmodium vivax Malaria Vaccine (OptiViVax)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,France,Sweden,Ireland,Ethiopia,Switzerland,United Kingdom,Portugal
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 3826044.75
EU funding (EUR): 3826043.75
Participants: 11
Project status: SIGNED

Plasmodium vivax is the most widespread human malaria with 2.5 billion people living at risk in South America, Oceania and Asia. The revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria, calling for a vaccine intervention to achieve 75% efficacy over two years, now equally weighted with P. falciparum. However, if this ambition is to be realised, new and innovative approaches are urgently required to accelerate next-generation vaccine research and development, whilst the few known candidate antigens need to undergo early-phase clinical assessment. Here, we build on exciting breakthroughs in P. vivax vaccine research, recently pioneered in Europe, including new transgenic parasite technologies for functional assay development and production of a parasite clone that is safe for use in controlled human malaria infection (CHMI) clinical models. The Objectives of OptiViVax will now integrate ambitious multi-disciplinary scientific and clinical approaches around the parasite’s lifecycle and will use our increased knowledge of P. vivax immuno-biology to further develop next-generation vaccines with improved efficacy. We will diversify the portfolio of new antigens ready for clinical testing by reverse vaccinology and diversify their delivery with new platforms and adjuvants developed using sustainable and improved GMP bio-manufacturing know-how. In parallel, the efficacy of known leading antigens will be benchmarked for the first time using innovative design of clinical studies and CHMI models making these lead candidate vaccines ready for future field trials. Improved preclinical functional assays, using state-of-the-art transgenic parasite lines, will also allow for mechanisms of antibody-mediated protection to be deciphered. The availability of new functional assays and human challenge models will underpin the future framework for informed decision making by the clinical vaccine community, policy makers, funders and regulators.

Keywords: vaccines,clinical trials,malaria,plasmodium vivax,tropical medicine,sporozoite stage,blood stage,transmission blocking,virus like particle,adjuvant,antigen discovery
Nature’s spin-flipping machine: design of the semiconductor-free biophotoanode (SpinBioAnode)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

Current challenges of humankind in coping with raising energy needs make it necessary to look for alternative technologies for harvesting renewable energy. One of the strategies is to construct biophotovoltaics that directly exploits naturally abundant and highly efficient photosynthetic proteins as photoactive components. My goal within SpinBioAnode is to construct the first generation of energy-efficient semiconductor-free biophotoanodes. To do so, I will design, assemble, characterize, and optimize a biohybrid photoanode consisting of a photosynthetic reaction center interfaced with electrode materials via an electron-conductive immobilization matrix. SpinBioAnode comprises a unique approach for solar energy conversion that hijacks a highly energetic triplet state formed by a spontaneous electron spin flip in purple bacteria photosynthetic reaction centers. This spin flip is biologically unfavorable, but potentially lucrative for biohybrid applications that require large open circuit potentials and high solar energy conversion efficiencies above 1% which to date, have not been achieved using state-of-the-art biophotovoltaics. I will apply a strongly interdisciplinary approach for characterization of the photoanode prototype using a combination of spectroscopic, electroanalytical and modelling methods. This will be achieved by collaboration within a network of physicists, chemists, and biologists. The characterization results will be utilized in the feedback loop workflow to optimize the constructed biophotoanode. Utilization of biologically unfavorable pathways within protein, opened by means of biohybrid approaches, is still an unexplored area in biophotoelectrodes design and the outcome of the SpinBioAnode project will serve as a blueprint in the wider field of light energy conversion in a road towards reaching Sustainable Development Goals such as affordable and clean energy.

Keywords: biohybrid devices,solar energy harvesting,triplet states,time resolved absorption spectroscopy
Climate tectonics interactions using big data-informed models (INITIATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,France,Germany,Spain,Greece
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3563020.8
EU funding (EUR): 3563020.8
Participants: 19
Project status: SIGNED

Earth topography and its subsurface are the result of complex interactions between tectonics and climate. Sediments in the shallow subsurface contain vital resources including water and energy that are crucial for mankind. They also provide temporary and longterm waste and energy storage. At the same time active deformation and rapid climate change interact posing significant risk for natural hazards such as debris flow, hillslope instabilities, and active faulting. The objective of the INITIATE doctoral network is (1) to fill key knowledge gaps how climate tectonics interactions on a wide range of spatial and temporal scales control distribution of sediments, landscape stability, and geohazards using big-data informed models, and (2) to improve urgently needed training in linking large data sets to deterministic forward models and machine learning. The training of a pool of DCs provides an excellent capacity building for the next generation of geoscientists. Combined training in large data, modelling, and entrepreneurial skills will prepare the DCs to create their own start-up business at the end of the project and / or be employed in industry or academia.

Keywords: modelling,large data,climate,tectonics,surface processes,geohazards,sedimentary basins
Developing Compassionate Workplaces in Europe for the digital and green work environment to protect employees’ mental and physical health and wellbeing (EU-CoWork)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Belgium,Sweden,Austria,Greece,United Kingdom
Call: Evidence-based interventions for promotion of mental and physical health in changing working environments (post-pandemic workplaces) (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 3871498.75
EU funding (EUR): 3871498.75
Participants: 8
Project status: SIGNED

EU-CoWork aims 1) to explore and understand the influence of changing workplace organization due to the twin transitions on well-being, performance, job quality, and work culture for employees confronted with serious illness, family caregiving, death, dying and loss (EoL experiences) and their colleagues; and 2) to develop and evaluate tailored Compassionate Workplaces Programs (CWPs) as health promotion strategies to maintain and support employee health and wellbeing in the work environment, across different national and labour contexts in Europe. The core of this project is a 4-country cross-national mixed-methods intervention study with an embedded process and impact evaluation. The project consists of 2 separate studies that feed into each other: a) an international co-creative and developmental evaluation of tailored CWPs, and b) an international mixed methods process and impact evaluation combining a timed series of quantitative cross-sectional panel surveys, qualitative interviews and fieldwork, and policy document analysis. Tailored CWPs will be developed in 12 European workplaces. EU-CoWork will provide findings about workplace compassion and mental and physical health and wellbeing of European employees in several working sectors, and the relationship between workplace characteristics and compassion at work and the health and wellbeing of employees confronted (directly or indirectly) with EoL experiences. The project will collect data about the relationship between employees’ EoL experiences, the company’s responses to these experiences and company and employee performance, and about the variability in workplace policies in Europe that address such risk factors. EU-CoWork will thereby offer insights and building blocks needed to create work environments that ensure adequate support and policy and that are tailored to counter-balance experiences that may otherwise exacerbate the risk for adverse mental health and wellbeing outcomes for employees.

Keywords: serious illness health promotion occupational health public health compassionate workplaces
Next-Gen Wireless Chip and Antenna Tech for Wi-Fi 8 (SWIFT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Pharrowtech's innovative project aims to revolutionize wireless communication by integrating millimeter-wave (mmWave) technology into the future Wi-Fi 8 ecosystem. Leveraging expertise developed over 15 years at imec, a global leader in nanoelectronics, semiconductors and digital technology, Pharrowtech focuses on advancing chip and antenna technologies that promise to propel Europe to the forefront of wireless communication. This project envisions Wi-Fi 8 as a transformative force, offering speeds up to 100 times faster than the state-of-the-art and ensuring reliable, high-performance connections. By tapping into the mmWave spectrum, offering 10x higher frequencies and 10x wider bandwidth, Pharrowtech addresses the spectrum shortage, making connections more robust as data demands continue to increase in our digital world. The proposed project prepares the ground for the integration of our mmWave technology into Wi-Fi 8. The work encompasses optimization of wireless system design, refinement of critical components through RFIC and analog block design, enhancement of adaptability through digital processing and software development, and real-world validation to overcome challenges like signal penetration and range limitations. This undertaking positions Pharrowtech as a key player in addressing the evolving needs of various industries, including smart cities, Industry 4.0, healthcare, AR/VR and beyond. The successful execution of this project not only signifies technological leadership but also opens new markets, enhances Pharrowtech's competitive edge, drives revenue growth, and fosters strategic partnerships, reinforcing the company's commitment to reshaping the wireless communication landscape. It will also help strengthen the EU’s technological sovereignty in this key sector.

Keywords: millimeter wave mmwave,wi fi 8,wireless communication,high frequency technology,high speed wireless communications,antenna design,telecommunications,semiconductor design,wi fi
Digital solution for robotizing manufacturing operations that learns from human demonstrations, allows workers to supervise its outputs and receives feedback to immediately correct its imperfections. (Neurofabrix)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 3141648.57
EU funding (EUR): 2199154.0
Participants: 1
Project status: SIGNED

RoboTwin is a progressive deep-tech start-up established in 2021 by three founders with experience in robotics, automotive and manufacturing industry. Our vision is to become #1 no-code robot programming solution in the world by bridging the gap between cutting edge technology and industry. The aim of this project is to develop the last mile of our robotics solution Neurofabrix for automation in manufacturing industry and productize it and scale it through feedback from a pilot program in real industrial applications to successfully launch it on the European market. For the first time a system is capable of automatically generating robotic programs using an AI knowledge model to flexibly control industrial robots in manufacturing production with needed robustness and trustworthiness. Neurofabrix, a novel robotics solution for automating manufacturing operations, autonomously generates robot programs, learns from human demonstrations, allows workers to supervise its outputs and directly teach it and uses feedback from this supervision to immediately correct its imperfections and improve in the long term. The Neurofabrix project contributes to the mission of strengthening the innovative performance of European companies and responding to industrial transformation, technological and societal changes. The project results in a first of its kind no-code robotics solution for industrial automation that meets the needs of the manufacturing industry.

Keywords: robotics,ai,industrial automation,manufacturing,surface treatment,knowledge model,human centric,digitalization,upskilling
A novel embryo transfer technology to improve pregnancy rates (TD System)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-07-01
End date: 2027-07-31
Duration (months): 25.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Infertility affects 1 in 6 couples globally, impacting over 186 million people. Assisted reproductive treatments, such as In Vitro Fertilization (IVF), offer solutions, but success rates remain low, with fewer than 1 in 4 patients achieving a live birth. The primary cause of failure is unsuccessful embryo implantation, where embryo transfer procedure — a manual process used for over 40 years, guided by tactile sensation and the operator’s experience — plays a critical role. To address this challenge, Premium Fertility has developed the TD System, a medical device based on live imaging, automation, and robotics. This innovation allows operators to perform precise, safe, and highly controlled embryo placements into the endometrial tissue. With this groundbreaking device, we aim to achieve pregnancy rates of up to 90%, representing a leap into the future of IVF with global impact. The TD System has reached TRL 6, with a fully functional product validated as an MVP, confirming its functionality and safety for real-world use. We are now prepared to take the next steps to bring this innovation to market, focusing on (i) ensuring safety and efficacy through clinical trials in the EU and USA, and (ii) finalizing the design to meet regulatory requirements and ensure a smooth transition to mass production. With significant market potential, Premium Fertility targets IVF clinics and hospitals worldwide, offering a scalable business model through direct sales and distributor partnerships. The TD System includes consumables and maintenance services, with projected cumulative revenues of €69M by 2031. Key strategic milestones include obtaining regulatory approvals in the EU, US, and other regions, supported by clinical trials and early adopters. EIC Accelerator funding will facilitate the completion of development and clinical validation, stablishing the TD System as the gold standard in fertility clinics, enhancing patient outcomes and reducing healthcare costs.

Keywords: assisted reproduction technologies art,in vitro fertilization ivf,embryo transfer,embryo implantation,infertility
Divergence times, Evolution, and Anatomy Deciphered in early Sharks (DEADSharks)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The ancient elasmobranchs (sharks + rays) have the potential to provide great insight into evolutionary processes over large timescales, but this potential is limited by a poor understanding of the relationships between living and extinct groups and the timing of major divergence events. In this project I will address these knowledge gaps by combining new 3D tomographic data on key Mesozoic elasmobranch body fossils with genomic and anatomical data from their living relatives. I will then use this and a dataset of 3D elasmobranch lower jaws to investigate the dynamics of elasmobranch macroevolution, using the rate and mode of lower jaw shape evolution as a case study. In doing so I will build on my existing background in palaeobiology and 3D methods by learning new skills in genomics-based phylogenetics and 3D geometric morphometrics, while developing my skills as a supervisor, communicator, and leader. These new skills, along with the scientific groundwork laid by this project, will give me the tools to pursue an independent programme of research in the longer term, investigating the early evolution of elasmobranchs by combining data from animals both living and extinct.

Keywords: chondrichthyans,elasmobranchs,evolution,palaeobiology,phylogenetics,macroevolution,disparity,mesozoic,tip dating
Direct Air Carbon Capture designed for the Gigaton Scale (StackDAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Direct Air Capture (DAC) is set to play a crucial role in solving one of the most complex problems of our time: bridging the emissions gap and cleaning up both historical and hard-to-abate emissions. It’s the only solution that can permanently and verifiably remove carbon dioxide from the atmosphere. But as promising as DAC is, it’s also an enormous technical challenge, considering that while CO2 levels are high enough to drive our climate change, they make up just 0.04% of the air we breathe. To truly reduce atmospheric CO2 levels and recover gigatons of atmospheric CO2 each year, DAC technology must be environmentally friendly, socially responsible, and scalable at a global level. At RepAir, we’re developing the technology that will make make this a reality with our cutting-edge, fully electric DAC technology, engineered as a trully scalable solution at the gigaton scale.

Keywords: direct air capture dac carbon removal net zero technology electrochemistry
UNcertainty quantification and modelling Bias Inhibition by means of an Agnostic Synergistic Exploitation of multi-fidelity Data (UN-BIASED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-04
End date: 2024-10-03
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

The UN-BIASED project aims at developing an innovative Scientific Modelling paradigm capable of mitigating potential cognitive biases affecting the modelling process in engineering applications. Nowadays, modelling is mostly a subjective process, strongly driven by the prejudice of the Modeller and anchored to the knowledge of well-determined pre-set physics. In practical applications, this often results into models affected by epistemic uncertainty. Data-driven techniques open the path for the construction of computerized models that are able to learn the physics underlying a complex system from the available data alone, requiring little, if not at all, subjectivity. Interestingly, these tools are generally used to obtain mere predictions and no credit is usually given to the possibility of translating the learned patterns and relations into interpretable theories and hypotheses. I propose to assess the physics learned by data-driven algorithms in terms of compliance with fundamental principles e.g., laws of thermodynamics, and to test them against a priori subjective hypotheses. This will expose differences between the actual experiment and the Modeller’s understanding of it. This allows for inverting the rationale underlying the classical modelling process, from a theory-to-data deductive assessment to a data-to-theory inductive inference. The ultimate goal is to advance the state-of-the-art by crafting a two-way modelling framework combining the hypotheses-driven and the data-driven approaches, to mitigate the consequences of biased modelling choices and improve the knowledge about complex physical systems. The proposed paradigm is not to be intended as a substitution of the classical Scientific Modelling method, but rather as an extension of it. The project is conceived with aerospace applications in mind, but the proposed methodology is straightforwardly applicable to the modelling of any physical problem of interest for the academy or the industry.

Keywords: uncertainty quantification,model epistemic uncertainty,uncertainty mitigation,model validation,multi fidelity modelling,data driven modelling,scientific modelling,data science