Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Norms in Nature: Rethinking the Natural Side of Normativity. Towards a New Hegelian Paradigm (NINA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

What are norms? Where do they come from? NINA aims to develop a new paradigm for thinking norms, moving beyond the prevailing but rigid dualism between norms and nature. It does so by excavating (and updating) a largely neglected tradition within Classical German Philosophy (CGP) with great potential for current scholarship. CGP is recognized as the origin of modern reflections on norms (the so-called “normative turn”).However, prominent philosophers have imported ideas from CGP into current debates to defend "non-naturalist", "constructivist” theories of norms. Aside from being historically inaccurate, these theories setup a problematic dichotomy between norms and nature, increasingly recognized as untenable. Yet there exists within CGP an alternative, forgotten line of thought –started by Kant and pursued by Hegel– that locates norms in nature. Rather than “leaving nature behind,” Hegel analyzed key natural-scientific notions (“organism", “function” etc.) to reveal forms of normativity in nature. NINA aims to recover this unexplored tradition. Bringing together the most up-to-date EU and US research in CGP with the best work on “normativity” and “naturalism”, it will: (1) Open a new narrative in the growing field of the “history of metanormativity”, by disclosing the post-Kantian tradition of normativity in nature (2) Provide the first comprehensive reconstruction of Hegel’s views on natural normativity through direct dialogue with today’s debates on norms (3) Develop key Hegelian insights for current debates. NINA implements a unique cross- and inter-disciplinary program that uncovers promising ideas from the past and mobilises them to impact current debates. Offering outstanding, focused training to the ER, NINA will facilitate unique transfer-of-knowledge and develop pathways for future cooperation with prestigious US institution (i.e. the largest Consortium for German Philosophy in the US), thus greatly improving the study of classical philosophy in Europe.

Keywords: hegel,analytic hegelism,analitic kantianism,philosophy of nature,normativity
Thrombotic MEMOry-Linking a break in tolerance to platelets to REthrombosis (T-MEMORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 1483145.0
EU funding (EUR): 1483145.0
Participants: 1
Project status: SIGNED

Thrombotic diseases like venous thromboembolism (VTE) are leading causes of mortality worldwide, due to their unpredictable, relapsing occurrence. The strongest predictor of a thrombotic event is a previous thrombosis, implicating that VTE has systemic memory effects beyond local clot formation triggering thrombotic relapse. In T-MEMORE, I will go beyond the state-of-the art of thrombosis research by testing the ground-breaking concept that VTE is not only a local event, but a chronic, systemic disease caused by an immune response to platelets mimicking a break in tolerance. My recent research revealed that venous thrombosis is the outcome of a sterile inflammation primarily directed against one target: activated platelets. I found that platelet-directed immunity in turn fosters platelet activation and thrombotic vessel occlusion. The systemic and long-term thrombotic memory effects of platelet-directed immunity are unknown, but have important implications for unmet clinical needs: (1) identification of patients at risk of rethrombosis; (2) personalisation of the duration and type of secondary prevention; (3) discovery of new approaches for VTE prophylaxis beyond anticoagulants with their inherent bleeding risk. The thrombotic memory effect caused by a local thrombosis will be deciphered by innovative functional in vivo imaging in the bone marrow – as the site of platelet production – as well as spleen and liver – as sites of platelet removal (objective 1). The potential of manipulating platelet-directed immunity to prevent thrombotic relapse will be tested in a clinically relevant model of rethrombosis (objective 2). In a translational approach, I aim to uncover a platelet-directed immune profile in patients with recurrent VTE, which would be a key step towards a personalized, molecular-guided therapy (objective 3). The overarching aim of T-MEMORE is to prove the concept of thrombotic memory as an innovative approach for the targeted prevention of VTE recurrence.

Keywords: venous thrombosis,inflammation,platelets
Providing digitalised prevention and prediction support for ageing people in smart living environments (SMILE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Norway,Norway,Norway,Greece,Norway,Netherlands,Netherlands,Netherlands,Denmark,Canada,Denmark,Denmark,United Kingdom
Call: International cooperation in smart living environments for ageing people (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 5910463.75
EU funding (EUR): 3990792.0
Participants: 14
Project status: SIGNED

Drawing on practical situations that older people face in daily living, SMILE will create SMart Inclusive Living Environments (SLE) with novel eHealth solutions enabling ageing in place. There are 6 main objectives: 1. Identify the needs and preferences of older people while living in their home environments. 2. Undertake co-creation of easy to use digital solutions with older people and novel methods to involve people with dementia. 3. Develop a smart AI-based system (Digital Care Facilitator and Conversational Agent) to proactively support older people in daily living. 4. To provide acceptable digital solutions when these solutions are introduced into older peoples lives 5. Evaluate the SMILE package to assess replicability and scalability in enhancing living spaces supporting independent, active and socially inclusive living for older people. 6. Build Europe-Canada cooperation in replicating, scaling and extending the results of SMILE to benefit the very heterogeneous populations of older people in our societies. These objectives will be achieved by 3 workstreams based on trans disciplinary research: co-creative design and evaluation; digital care facilitator and conversational agent; SMILE SLE ecosystem and digital solutions. Our targeted breakthroughs for smart living environments supporting independent and active living are: a participatory SLE ecosystem model; the ‘Digital Care Facilitator’, an AI-based system [TRL6]; a conversational agent as an everyday intermediary enhancing social participation [TRL6]; personal mHealth apps, and eHealth monitors and devices [TRL5-8]. We will demonstrate that SMILE works for a very heterogeneous group with different needs and preferences: older people with severe dementia, Chronic Obstructive Pulmonary Disease (COPD) and care transitions during post-surgery recovery. With this combined package and related service improvements SMILE will go beyond state of the art in ways that are sustainable, scalable and exploitable.

Keywords: smart living environment,health related age impairments,reducing social exclusion risks,social participation,health and care systems,changing health status or care,patients,survivors of chronic
FILMEU_RIT - Research | Innovation | Transformation (FILMEU_RIT)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Estonia,Ireland,Belgium,Hungary,Portugal
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 1999521.25
EU funding (EUR): 1999521.25
Participants: 5
Project status: SIGNED

FILMEU_RIT brings together four European Higher Education Institutions: UL - Lusófona University from Lisbon, Portugal; SZFE – University of Theatre and Film Arts, from Budapest, Hungary; LUCA School of Arts from Brussels, Belgium; and IADT - Dún Laoghaire Institute of Art Design and Technology, from Dublin, Ireland. Together, these institutions collaborate around the common objective of jointly promoting high-level research, innovation and educational activities in the multidisciplinary field of Film and Media Arts and, through this collaboration, consolidate the central role of Europe as a world leader in the creative fields. FILMEU_RIT will increase the Alliance’s competitiveness and reinforce its ability to develop activities that span all the areas of the knowledge square: education, research, innovation, and service to society, while helping the creative sector to affirm its potential for innovation and resilience in a post COVID-19 context. FILMEU_RIT will develop a common R&I agenda for artistic research supported by common resources and joint structures that will increase talent attraction and the impact of the research developed amidst the alliance. Such impact seeks to promote greater engagement of society and business with art and creativity in order to increase European competitiveness and its artistic R&I profile. FILMEU_RIT’s main objective is the capacitation, in Research and Innovation terms, of the individual HEIs that integrate the Alliance via the joint design of strategies and action plans that ensure the transformation of the future European University into an Institution that puts Research and Innovation in the fields of Film and Media Arts at the centre of its activities and operates as a highly valuable critical cultural intermediary.

Keywords: artistic research,innovation,transformation,engagement,film,media,arts,filmeu
The Politics of Reading in the People’s Republic of China (READCHINA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

READCHINA is the first broad investigation into the politics and practices of reading in the People’s Republic of China (PRC), their interpretation and their impact on social and intellectual change. The main objective of the study is a reinvestigation of literary history and cultural policy of the PRC from the perspective of the ordinary reader. This grassroots approach is innovative in the writing of Chinese literary history as it means turning away from the established focus on authors and the political context. Instead, READCHINA will investigate the social conditions under which texts were read, what influences this had on the lives of individuals, on social, intellectual and literary change in China, and on the modes of production, distribution and consumption of literature. READCHINA considers the reading of literature as part of a wider web of reading materials, including different media and non-fictional texts. Primary sources will consist among others of archival material, field work interviews, autobiographies, marketing materials, statements by fans in online forums, and literary texts. Combining literary analysis with historical and ethnographical inquiry, as well as methods from the digital humanities, READCHINA will contribute to the fields of literary history and literary sociology. Moreover, in combining close readings of texts with distant reading methods, READCHINA will also foster our understanding of the meaning and impact of popular literature in China and of literary theories on reading. READCHINA will thus bring 20th and 21st century China into the global history of reading – especially so, as practices of reading in China have been shaped by different institutions than in the ‘West’: a Socialist State eager to reform its citizens by means of cultural policies, a centralized bureaucratic system regulating distribution and access to reading matters, and a highly efficient system of media control.

Keywords: chinese literature,20th and 21st century literature,history of reading,digital humanities
Gut epithelial dynamics and function at the nexus of early life infection and long-term health (EarlyLife)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

Infections of the gastrointestinal tract and their long-term consequences remain a major cause of childhood mortality and morbidity worldwide. In addition, early life is recognized as a critical and non-redundant time period to prime the mucosal tissue and establish the enteric microbiota that determine the risk to develop prevalent inflammatory, immune-mediated, and metabolic diseases. Three factors: the enteric microbiota, the mucosal immune system and the epithelial barrier cooperate to establish intestinal host-microbial homeostasis after birth. Maturation of the mucosal immune system and establishment of the enteric microbiota have been extensively studied. In contrast, postnatal evolvement of epithelial cell type heterogeneity and functional specialization and the influence of enteric infection on this process have not been explored. With EarlyLife, I propose to further advance innovative, multiscale technical approaches and analytical protocols in combination with novel in vivo models to generate the first comprehensive map of postnatal epithelial cell type and subtype differentiation and analyze the impact of early life infection by important human bacterial, viral and parasitic pathogens. Long-term inflammatory, immune-mediated and metabolic effects will be functionally studied using epigenetic profiling, microbiota-transfer experiments, stem cell organoid culture and co-culture, as well as genetic models. Identified mechanisms will be confirmed using single-cell analysis of human mucosal biopsies, human stem cell organoids and transcriptomic profiling of human fecal samples. As a result, I expect to identify mechanisms of enhanced infection susceptibility of the neonate, decipher the critical and non-redundant influence of the postnatal period for mucosal homeostasis and explain the role of early life imprinting for long-term immune-mediated, inflammatory and metabolic diseases.

Keywords: neonate,intestinal epithelium,gastrointestinal infection,enteropathogen,neonatal window of opportunity,microbiota,mucosal immunology,metabolism
A Novel Rapid Nucleic Acid Isolation Microchip Intergrated in the FASTGENE PCR Microfluidics Device for Point of Care Diagnosis of Infectious Diseases (NORAMID SE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The catastrophic impact of infectious diseases including the recent coronavirus (covid-19) pandemic on global health cannot be over emphasized. Polymerase chain reaction (PCR) based techniques are the most sensitive and reliable diagnostic tools for infectious diseases but are time-consuming and labour-intensive. This project aims to develop a simple, rapid and cost-effective novel nucleic acid (NA) isolation microchip and integrate it in the FASTGENE PCR microfluidics device for point of care (POC) diagnosis of infectious diseases. The project will exploit the competence of the experience researcher (ER) on the theoretical and practical knowledge of medical biotechnology and molecular epidemiology while implementing the expertise of BforCure team in microfluidics design to develop this new microchip. The ER will develop a new NA isolation microchip based on silica gel solid phase extraction system and integrate it in the FASTGENE PCR microfluidics device of BforCure to become a closed system device that automatically extracts NA and amplifies it to detect infectious diseases. After the design and production, the device will be tested for its efficiency. Once satisfied, positive control bacteria and viral samples will be used to assess the performance of the device and the results will be compared with that of standard commercially available NA extraction and PCR kits. The device is expected to have high sensitive compared to other microfluidics devices, reliable and can detect pathogens in less than 20 minutes. A patent will be secured for the product while the findings of the research will be made public and commercialized. This novel device will be suitable for POC diagnosis to promptly detect and manage infectious diseases. This project will develop the ER’s potential to transform research ideas to products and build up his industrial experience. It will make the ER gain expertise in the design and fabrication of microfluidics tools and develop his entrepreneuri

Keywords: infectious diseases,microfluidics,lab on a chip,point of care diagnosis,microchip,microfabrication
Global Excellence in Modelling of Climate and Energy (GEMCLIME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Australia,South Africa,Italy,Italy,Singapore,New Zealand,France,Czechia,United States,United Kingdom,United Kingdom,Canada,Chile
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 3330000.0
EU funding (EUR): 2115000.0
Participants: 23
Project status: CLOSED

The global GEMCLIME project focuses on major aspects of energy economics and climate change, which is a prime example of an important global and complex scientific and policy problem. GEMCLIME covers the drivers of climate change, the examination of climate change and energy-related risks and vulnerabilities, the valuation of economic impacts of climate change mitigation and adaptation policies, and the investigation of major policy responses to global climate and energy challenges. GEMCLIME follows an integrated approach to modelling the impacts of climate and energy policies. The analysis of drivers, impacts, and responses to climate change attributes particular attention to the economics of renewable energies and the valuation of non-marketed goods. While GEMCLIME is focused on fundamental economic research, our results also provide support to evidence-based policy. GEMCLIME brings together both globally and regionally the most excellent institutions and researchers with wide-ranging research experience in the context of a collaborative scheme of research exchanges and networking. The members of the consortium share their skills and knowledge from the areas of climate change, energy, resource, health, environmental, and agricultural economics, while drawing on the expertise of participants in financial economics, applied macroeconomics, microeconomics, and econometrics. Our consortium also includes researchers and academics from non-economic disciplines, including political scientists, sociologists, lawyers, environmental scientists, and other scientists related to climate and energy. The reciprocal transfer of knowledge between the members of the consortium is supported by a staff exchange including senior research fellows, professors, early-career academics, and doctoral students. Our global project aims at supporting research mobility between the EU on one side, and the USA, Canada, New Zealand, Australia, South Africa, Singapore, and Chile on the other side.

Keywords: economics of climate change,energy economics,mitigation,adaptation,consumer behaviour,energy efficiency,renewable energy,health risk,ecosystem services,discounting