Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Health Assessment Refinement for Mitigating Noise and AIR quality Effects (HARMONIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Research and Innovation actions
Countries involved: Spain,Italy,United Kingdom,Germany,Slovenia,Switzerland,Bosnia and Herzegovina,Sweden
Call: Zero-pollution cities (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 4995990.25
EU funding (EUR): 4995990.25
Participants: 19
Project status: SIGNED

The HARMONIE project takes a holistic approach to support informed policy- making by improving AP and noise monitoring, modeling, and forecasting as well as by providing tools to assess the health impact of actions on VP and the impact of actions in the long run on economy and sustainability of policies. The consortium will work in pilot cities to: 1) Enhance environmental monitoring and modelling by identifying key harmful variables. 2) Assess citizen exposure based on urban demographics, mobility, and vulnerability factors. 3) Evaluate health effects, both at the individual level (based on Digital Twin Lungs) and at the population level (computing mortality and morbidity). These components will be tested in real-world city scenarios, prioritizing pollution-abatement strategies. The methodology includes two key approaches: ● PILOTS: Data collection from Gävle (GAV), Sarajevo (SRJ), Lausanne (LAU), Barcelona (BCN) city and province, and Barakaldo (BRK), identifying vulnerable populations, monitoring pollutants (AQ & noise), and analyzing related health outcomes. ● DIGITAL TWIN: A Citizen-Centric Digital Twin (CCDT) will visualize pollution hotspots, engage citizens through interactive platforms, and integrate a social dynamics model to assess both health and healthcare system impacts under different scenarios. HARMONIE will enable ‘What-If’ scenario simulations within the CCDT, allowing policymakers to benchmark strategies and select optimal interventions. To ensure long-term impact, the project will integrate developments into existing city infrastructures, enhancing policy communication and decision-making with cutting-edge digital tools. By integrating community-driven data, What-If scenarios, and behavioral insights, it helps overcome psychological and social barriers to zero-pollution initiatives. Through dynamic simulations and feedback mechanisms, it engages citizens and institutions to develop actionable strategies tailored to urban communities.

Keywords: air quality noise respiratory system psycology and behaviour mobility digital twins oxidative potential and health
Towards a Sociology of Debt Stratification and its Moral Foundations Across Countries (SOCDEBT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1485917.5
EU funding (EUR): 1485917.0
Participants: 1
Project status: SIGNED

The financialization of households in the 21st century has made credit and debt central to economic disparity, reshaping financial burdens and opportunities. Debt shackles the poor, limiting mobility, yet also offers leverage for the wealthy, enabling further investment, accumulation, and opportunity. This paradox of debt lies at the heart of SOCDEBT, which is built around four key goals: (1) SOCDEBT will examine debt stratification across 35 countries over three decades, identifying the social groups most likely to be indebted, the types of debt carried, and variations across countries and time; (2) the project will explore debt accumulation, particularly in response to (adverse) life events, and how this process varies across social groups and national contexts; (3) it will investigate debt practices and the factors influencing individuals' decisions to take on debt, strategies for repayment, and the role of social influences, such as peers; and finally (4) SOCDEBT will explore the moral economy of debt, examining how different social groups view debt and credit across countries, examining cultural and moral dimensions and how evaluations vary between working and middle classes. SOCDEBT transitions from investigating micro-level variations in household debt stratification to exploring meso-level debt practices and moral evaluations. This comprehensive approach will address critical gaps in understanding how debt stratification and accumulation vary across societal settings. By combining innovative statistical methods with multiple nationally representative household surveys for up to 35 countries across all continents and over time, along with new survey-experimental data and focus groups in five European countries, SOCDEBT will challenge and reshape our understanding of contemporary economic inequality dynamics around the world. Lastly, it will establish a new subfield of sociological inquiry: the Sociology of Comparative Debt Stratification

Keywords: social stratification,economic sociology,debt and credit,moral economy
Arithmetic of Curves and Jacobians (CurveArithmetic)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: TERMINATED

The study of the arithmetic of curves is as old as mathematics itself and takes on many forms. In some cases, such as Fermat's Last Theorem or Mazur's torsion theorem, one tries to prove that a sequence of curves with growing genus has no interesting rational points. In other cases, such as the study of rational points in families of elliptic curves, there is no way to classify all solutions, but one tries to understand what is happening on average. A third approach aims to link the existence of rational points on a given curve to the preponderance of points on the curve modulo larger and larger prime numbers. This is the idea behind the Birch and Swinnerton-Dyer conjecture, and its generalization, the Beilinson-Bloch conjecture. The proposed research makes progress in each of the three paradigms above. In corresponding order, we propose a Mazur-type theorem for a family of unitary Shimura curves, by exploiting the Jacquet-Langlands correspondence and a connection with Prym varieties. A special case of this result would give a classification of torsion points in a family of genus three bielliptic Jacobians. Second, we propose an approach to the Poonen-Rains heuristics for elliptic curves by combining twisting methods with Bhargava's geometry-of-numbers methods for universal families. Using similar methods, we aim to show that Hilbert's tenth problem has a negative answer over every number field. Third, we study certain instances of the Beilinson-Bloch conjecture for the degree 3 motive of the Jacobian of a curve with complex multiplication. The strategy involves the construction of an Euler system composed of CM Ceresa cycles. Related work will explore torsion and infinite generation phenomena for Ceresa cycles, as well.

Keywords: elliptic curves,curves,abelian varieties,rational points,jacobians,shimura varieties,algebraic cycles
Innovative Microbiome-Based Therapies: Redefining Treatment for IBD and Cancer Patients (IMPACT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Romania
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2.48
EU funding (EUR): 2.48
Participants: 1
Project status: SIGNED

Through advanced AI-driven microbiome analysis, NostraBiome is transforming chronic disease management, particularly for inflammatory bowel disease (IBD) and cancer. Our solution has shown remarkable results, increasing treatment response rates for IBD from 40% to 100% in clinical trials involving 27 patients, with plans to expand to 60 pediatric patients. With €0.68 million allocated for further clinical trials across the EU and a forecasted revenue increase to €200,000 by the end of 2024, NostraBiome aims to capture 5-10% of the Serviceable Obtainable Market (SOM) in key European countries within the next 5-7 years. EIC funding will be instrumental in scaling our impact, securing regulatory approvals, and extending our reach to millions of patients across Europe to optimise public and private spending in healthcare.

Keywords: personalised medicine microbiome analysis ai driven healthcare chronic disease management ibd treatments immunotherapy optimisation
ELEM Virtual Heart Populations for Supercomputers (ELVIS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-08-31
Duration (months): 30.0
Total project cost (EUR): 3545852.5
EU funding (EUR): 2482096.75
Participants: 1
Project status: CLOSED

ELEM’s V.Heart is a supercomputer-based platform to perform massive in-silico clinical trials on populations of digital avatars generated through a database of real medical data, to study the outcomes of different therapies. It assesses the safety and efficacy of novel therapeutics, devices or drugs, by computing thousands of scenarios. Current capability covers classic or leadless pacing and cardiac pumps and cardiac safety of drugs. Our plan is to add new therapies whilst increasing the range of our patented virtual population technology. V.Heart generates unparalleled medical insights and new evidence for biomedical professionals whilst shortening time to market and reducing business and patient risks. It narrows the scope for animal testing and tapers real human trials by evaluating clinical study endpoints much faster and earlier in the development process. Eventually, digital avatars become a Digital Twin of any given patient used as a predictive tool for precision medicine.

Keywords: cardiac and cardiovascular systems,scientific computing,simulation and modelling too,health related biotechnology,medical devices,advanced computing,machine learning,statistical data processing and
Real-time multi-spectral imaging for accurate detection of cancerous tissue in endoscopic surgery (rMSI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 4092151.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Cancer is the leading cause of death in the EU, with 2.7M diagnoses and 1.3M deaths in 2020. Effective removal of cancerous tissue through endoscopic surgery is challenging because of limited visual and absent tactile information, along the limitations of current imaging technologies, which make it difficult for surgeons to differentiate between different types of tissue. For this market, Thericon is developing an rMSI (real-time multispectral imaging) platform providing surgeons with multi-parametric images that help with effective removal of cancerous tissue and reduction of cancer recurrence in patients. The company has developed a prototype for its first product, named rMSI 2, and completed initial validation for bladder cancer applications. Thericon is asking for a 2.5M EIC grant and 5.5M equity funding to complete clinical application pilots, safety tests and CE certification for this product, getting it ready for market launch in 2024.

Keywords: bladder cancer,endoscopy,endoscopic surgery
VIDEM-POC: ACCESSIBLE & AFFORDABLE LAB-ON-A-CHIP POINT-OF-CARE DISEASE DIAGNOSTICS (VIDEM-POC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Diagnostics are essential for effective healthcare, yet nearly 50% of the global population lacks access to proper diagnostic services, particularly in primary care, affecting the health of 3.7 billion people. Diagnosis is the biggest gap in the cascade of care, hampering not only individual health outcomes but also public health. Centralized diagnostic systems often cause delays in test results (days to weeks) leading to serious consequences for timely treatment and increased healthcare costs. The high cost of tests further limits accessibility and exacerbates socioeconomic disparities. Point-of-care (POC) diagnostics aims at providing rapid, convenient testing near patients. Despite organizations like FIND and the CDC advocating for POC supportive policies, adoption of current POC solutions is limited by poor multiplexing capabilities and high costs. VIDEM-POC is a next-gen, low-cost, handheld, easy-to-use, accurate POC diagnostic instrument with a wide menu of different disease panel specific test lab-on-chip cartridges. Our technology will be first-of-its-kind to truly offer affordable symptom-driven disease testing directly at the POC with results in minutes. VIDEM’s technology is robust and highly versatile, applicable to bacteria, viruses, parasites, fungi and proteins, therefore able to address current, emerging and future health challenges. VIDEM’s first focus is syndromic testing (i.e. multiplexing) for infectious diseases – starting with sexually transmitted infections (STIs), which are a huge public health challenge with over 374 million new cases reported each year worldwide and showing a troubling surge in the EU. Our technology is at TRL5, and we now need the support and funding of the EIC to finalize VIDEM-POC solution and enable market entry for its first application, STIs diagnostics, contributing to European and global health and saving millions of lives in Europe and around the globe.

Keywords: point of care testing lab on a chip surface acoustic wave sensor sexually transmitted infections
Implementation and production of an Accurate and Accessible molecular diagnostic Test for highly prevalent Sexually Transmitted Infections. (IMPACT-STI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Rapidemic envisions a world where anyone can access quality diagnostics, anywhere, anytime. Our mission is to become a leading global diagnostic innovator and developer of rapid and reliable decentralized molecular diagnostic solutions. Our first product is a state-of-the-art molecular point-of-care test for fast and accurate diagnosis of highly prevalent sexually transmitted infections. According to the WHO, sexually transmitted infections (STIs) infect over 374 million people worldwide every single year. The current diagnostics present important shortcomings: they are either slow or highly inaccurate. There is an important unmet need for more accessible, fast and accurate STI tests, particularly for Chlamydia and gonorrhea. Rapidemic is uniquely positioned to address this 3B$ gap in the European and US market with RapiDetect: a novel 15-minute molecular diagnostic test that brings the accuracy of lab-based technologies directly closer to patients, to provide low-threshold, accurate and immediate (single-visit) diagnostic testing, with a fully stand-alone, disposable test cassette. In this project, Rapidemic will work to bring their first product from a TRL 5 to 8 (Phase I), to scale-up (Phase II). Key elements include product development milestones, advancing our alpha prototype to beta prototype, through thorough verification and validation processes under the ISO 13485 regulation with the ultimate goal of a CE-IVDR and UKCA certification. In parallel, we will increase our marketing and commercial activities by building a global network of stakeholders, potential clients/users, key opinion leaders, distributor networks, and user community and paving the way to launch our first product, RapiDetect CT/NG for a point-of-care indication in primary healthcare settings in 2027. We will then initiate activities to recertify our point-of-care test for an at-home indication to launch in the USA and the EU.

Keywords: molecular diagnostics,ppint of care,sexually transmitted infections,scale up,product development,commercialization
Generalised Integrality and Applications to Number Theory (GIANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Bulgaria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 120812.16
EU funding (EUR): 120812.16
Participants: 1
Project status: SIGNED

In this proposal semi-integral points refer to notions of rational points on algebraic varieties that satisfy an integrality condition with respect to a weighted boundary divisor. They were first introduced by Campana and by Darmon. Campana points have recently risen to the attention of the number theory community thanks to a Manin type conjecture in the recent work of Pieropan, Smeets, Tanimoto and Várilly-Alvarado. Semi-integral points provide both an intermediate notion and a generalisation of the notions of rational and integral points, thereby unifying the two theories. This proposal concerns the existence of semi-integral points and the density of orbifold pairs in general families having semi-integral points. The aims of this proposal are to determine good upper bounds for the density of orbifold pairs in a general family that have semi-integral points (WP1) and to compute obstructions to the existence of semi-integral points (and hence to integral points) in key examples corresponding to long-lasting questions in number theory (WP2). The approach will combine a variety of techniques from analytic number theory, algebraic geometry and arithmetic statistics. For (WP1), the experienced researcher and the supervisor will develop a criterion to detect local semi-integral points together with a sieve method to estimate the number of everywhere locally soluble varieties in the family. For (WP2), the research team will develop a Brauer-Manin obstruction theory for semi-integral points to compute failures of the integral Hasse principle in fundamental examples and handle classical Diophantine problems such as the existence of integral points on diagonal cubic surfaces and the non-existence of consecutive powerful numbers.

Keywords: semi integral points,campana points,darmon points,rational points,integral points,hasse principle failures in families,hasse principle failures,brauer manin obstruction,large sieve
Faith-Based Refugee Relief in Europe: Connecting the Empirical and the Ethical (FABRIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1487796.0
EU funding (EUR): 1487796.0
Participants: 1
Project status: SIGNED

FABRIC develops a new ethics of migration by understanding and utilizing the moral insights and the moral ideas that faith-based refugee relief organizations develop and deploy in practice for the cross-disciplinary debate about the ethics of forced migration in Europe. Globally, forced migration is one of the most pressing and one of the most pervasive challenges. Europe has been pushed to a social and political breaking point over migration. The fallout is a death toll that makes the border around the continent the deadliest border in the world. Faith-based organizations (FBOs) have been at the forefront of this challenge, preventing the collapse of the infrastructures of care, combatting racist discourse and religious discrimination. Yet there is very little knowledge about the refugee relief of these FBOs so their significance for the ethics of migration has been neither analyzed nor assessed. FABRIC addresses this lack by conducting a comprehensive and comparative empirical exploration of FBOs at an unprecedented scale, covering activities by FBOs from all three Abrahamic faiths in mono- and multi-religious settings across the continent. Countering the lack of interaction between empirical and evaluative approaches so characteristic of the study of forced migration, FABRIC presents a pragmatist understanding of ethics to enquire into the conditions, constraints, and consequences of practicing justice. It offers a concrete account of faith-based refugee relief in order to formulate a new concept of mobility justice that considers cross-connections between social, racial, and climate justice on regional, national, and global scales. Thus, FABRIC formulates a new ethics of migration from the bottom up, putting the debate about the ethics of migration on an empirically more perceptive and ethically more productive footing that advances knowledge production on forced migration across the academy.

Keywords: ethics,migration,faith based organizations,europe,philosophy,sociology,religious studies