Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commercial feasibility study of a technology that multiplies blood stem cells to increase the success of transplants for cancer treatment (BloodStemPLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Portugal
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

StemCell2MAX is a biotechnology start-up that owns a proprietary solution for multiplying blood stem cells. Blood stem cells are required for both research and blood cancer treatment, but are scarce resulting in limited transplants (34% of patients do not find a donor), patient death (6-15%) and limitations at research level (12.500 groups lack cells for their studies). StemCell2MAX addresses this enormous demand from patients, cord blood banks, hospitals and researchers in an estimated €3 billion potential market (33% CAGR). No solution for blood stem cell multiplication is available for clinical purposes and those that are currently used for research purposes compromise cell quality. StemCell2MAX has developed a product that multiplies these cells while assuring their quality (20x better results compared to state of the art, as published in Nature). Currently, StemCell2MAX markets a research use only product (€600M market) with a growing sales track record, both in EU and USA. Following the technology’s market acceptance and scientific recognition, StemCell2MAX is preparing their solution for the €2.4B clinical market. The innovation is protected in EU, USA and Japan for blood stem cell maintenance, expansion or transplantation, for both research and clinical use. StemCell2MAX won the “most investable company” award during the first Horizon 2020 – Invest Horizon Global Investor Summit in November 2015. Specific objectives: • To develop a business plan and marketing strategy for clinical application • To explore strategic partnerships for development and commercialisation • To explore the clinical validation strategy/clinical trial design • To develop a strategic development plan in agreement with reimbursement policies Expected outcomes: • A business plan and optimal route-to-market, including partnering strategy for further development • Clinical trial strategy in compliance with all regulatory requirements

Keywords: blood stem cells,stem cell transplantation,cancer,neurotrophic factors
The psychology and neurobiology of cognitive control training in humans (CCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2022-10-31
Duration (months): 84.0
Total project cost (EUR): 1998305.0
EU funding (EUR): 1998305.0
Participants: 1
Project status: SIGNED

Cognitive control regulates our thoughts and actions, helping us avoid impulsive behaviours that are inappropriate, costly or dangerous. In recent years, evidence has emerged that training in behavioural tasks that promote response inhibition or avoidance of specific stimuli can enhance cognitive control, reducing overeating and alcohol consumption. Despite the promising nature of cognitive control training (CCT), we know little about which CCT methods are most effective, how individual differences determine training outcomes, whether CCT produces benefits for real-life behaviour, and how CCT alters – and is determined by – the structure and function of the brain. My aim is to discover what works in CCT and how the effects of training relate to neurophysiology. Subproject 1 will be the largest ever trial on the effectiveness of different CCT methods for achieving weight loss, recruiting 36,000 participants worldwide to complete an internet-based training programme via the Guardian. This study will reveal, with high statistical power, which CCT methods are the most effective and which individual differences are most important for producing real-life benefits. Subproject 2 will investigate how CCT influences neurobiology, and how individual differences in neurobiology influence CCT outcomes. In Subproject 2a, I will focus on theoretically predicted changes to GABAergic systems in prefrontal and motor cortex, and I will test the effect of GABAergic brain stimulation on training outcomes. In Subproject 2b, I will use concurrent brain stimulation (TMS) and brain imaging (fMRI) to test how CCT alters top-down coupling between prefrontal cortex and remote regions that mediate reward and emotion. I will also study how CCT alters, and is altered by, white matter microstructure. This project promises to advance understanding of the causal determinants and moderators of CCT, with implications for its suitability as a clinical adjunct in addiction therapy and behaviour change.

Keywords: cognitive control,response inhibition,cognitive training,brain stimulation,neuroimaging,transcranial magnetic stimulation,functional magnetic resonance imaging
Establishment of the Bioinformatics ERA Chair at the Cyprus Institute of Neurology and Genetics (BIORISE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Cyprus
Call: ERA Chairs (H2020-WIDESPREAD-2014-2, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 2526162.5
EU funding (EUR): 2273546.0
Participants: 1
Project status: CLOSED

The BIORISE project proposal aims at the establishment of a Bioinformatics ERA Chair at the Cyprus Institute of Neurology and Genetics (CING). CING is currently the most advanced organisation of Cyprus in the fields of Neurology, Genetics and Biomedical Sciences and its research infrastructure is strongly supported by European Structural and Investment Funds (ESIF) through the Cyprus Directorate General for European Programmes, Coordination and Development. Through BIORISE the CING will attract talented Bioinformaticians who will be integrated within its current organisational structure to satisfy urgent needs for Bioinformatics analyses. The CING has recently established a Translational Facility infrastructure, through the ESIF and Norway grants, that will be producing a substantial amount of genomics and proteomics data. Due to budget limitations and the current economic constraints of the country, recruitment of expert Bioinformaticians has not been possible. Therefore, establishment of the Bioinformatics ERA Chair through this funding opportunity will complement and upgrade the above investments, since it will enhance the timely analysis of data and contribute towards excellence in extraction of reliable and meaningful results from large biological datasets. Furthermore, the more effective analysis of genomic and proteomic data will increase the capacity and level of excellence of CING thus promoting participation in competitive research proposals at national and international levels. In addition, BIORISE will facilitate the introduction of a Bioinformatics course within the postgraduate programmes of the Cyprus School of Molecular Medicine thus promoting the education and training of young scientists in the cutting edge field of Bioinformatics. BIORISE will have an impact at organisational, national, European and international level resulting in new multidisciplinary networks and increasing mobility thus complementing and upgrading existing infrastructures.

Keywords: bioinformatics,omics data,innovative research potential,education and training
Optical NanoActuators for Nanomachines and Microfluidic Chips (ANTNAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 144549.0
EU funding (EUR): 144549.0
Participants: 1
Project status: CLOSED

Over the past 2 years we have developed and patented a new actuator which is based on composite polymer/metal nanoparticles. Originally designed to create strong reversible colour changes, we found that the forces generated in the actuation exceed current microscale devices by nearly two orders of magnitude (weight for weight). We have thus protected and developed this possibility using my Advanced ERC project, LINASS, together with Cambridge Enterprise (CE, the commercialisation arm of the University of Cambridge). We have now reached the stage where we believe that this can become commercially interesting, have progressed to a better understanding of the fundamental processes, and have some idea of the applications that it might enable. The PoC project here is thus conceived to create demonstrators in two related domains: one offers new possibilities in advancing the established technology of microfluidic chips, while the other opens up a new space entirely, by making DNA nano-machines active and feasibly exploitable.

Keywords: nanomachine,actuator,plasmon,polymer,microfluidics,pump
INvention of SCRIpts and their BEginnings (INSCRIBE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 1463337.0
EU funding (EUR): 1463337.0
Participants: 1
Project status: SIGNED

Writing must rank among mankind’s highest achievements. Yet the factors that enabled its invention independently in different parts of the world have never been subject to an analysis from a multidisciplinary and comparative perspective that encompasses both deciphered and undeciphered scripts. INSCRIBE takes such an approach, combining a study of the world’s first instances of writing, including the earliest in Europe, through the lens of archaeology, anthropology, cultural evolution, cognitive studies and decipherment strategies. This methodology involves three strands of research. First, it will consider the original inventions, all of which are image-based, from Mesopotamia, Egypt, Mesoamerica and China, and other debated cases. The objective is to characterize their conception in terms of visual cognition (why are signs shaped as they are?), archaeological setting (what are the contextual preconditions, why does writing emerge when it does, and only four times in history?), application of use (what are its initial purposes?), and language notation (what are the paths to registering sound?). Second, it will explore the earliest scripts in Europe from the second millennium BC Aegean, whose initial phase is highly iconic. The three undeciphered Aegean scripts (Cretan Hieroglyphic, Linear A and Cypro-Minoan) will be analyzed for the first time from a multistranded perspective that will shed unprecedented light on their creation and development. The objective is to analyze the relationship between these scripts and to apply a multi-stepped (and already successfully piloted) decipherment strategy. Third, INSCRIBE proposes to go beyond the traditional standards applied to the corpora of inscriptions by producing the first complete digital corpus of all three Aegean undeciphered scripts, with 3D interactive models accompanied by a multidimensional interface tagging inscriptions, types of inscribed objects, provenance, archaeological contexts and functions.

Keywords: decipherment strategies,writing systems
INSPECTO: A disruptive portable device with an innovative Method for Pesticides and contaminants Detection in Food (INSPECTO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

More than 97% of European food products contain pesticide residues, according to analyses carried out by the EU’s national authorities; in fact, annual compilations showed that of the 84,341 samples of produce from conventional agriculture analysed, 97.2% contained traces of one or more of 774 pesticides. In 2016, the America’s food industry had a $55.5 billion safety problem according to Fortune magazine, because of produce recalls and money spent on food testing. In addition, consumer demand for healthy, clean produce drives the food industry to invest more in food safety to brand their product as healthy. Current methods for detecting contaminants in food do not meet the industry’s requirements. They are too slow, stationary, complex to operate and expensive. The industries need and a global policy for reducing pesticide use are a huge opportunity for INSPECTO’S development. Unlike existing solutions such as mass-spectrometers and lab services that offer slow, limited and expensive services, INSPECTO offers an innovative method for the detection of pesticides and contaminants in food. Our unique developments are in the field of spectroscopy allowing quick, simple and affordable detection of contaminants in food (United States Provisional Patent Application No. 62/436,571). The POC was developed in conjunction with input from food industry professionals, to be used by regulators, growers, handlers, producers, retailers and 3rd party systems such as Blockchain. OUR BUSINESS MODEL: INSPECTO offers three services; (1) sale/lease of the Inspecto’s device & licensing, (2) refill of Inspecto’s disposable cartridges, and (3) subscription to Inspecto’s data analysis. Our main objective is to make INSPECTO the global reference technology enabler to reveal pesticides in food, helping regulators and business to sell the best quality and consumers to acquire the safest products.

Keywords: pesticides,contaminants,detection,food,safety,device,innovation
Side-Channel Aware Engineering (SCARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Finland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1499950.0
EU funding (EUR): 1499950.0
Participants: 2
Project status: SIGNED

As the recent "HeartBleed" bug in OpenSSL demonstrates, the security of cryptographic software and devices cannot be understated. They build the foundation for basic security guarantees such as confidentiality and authentication, enabling technologies such as secure communication. For example, Transport Layer Security enables e-commerce, a 1.9 trillion USD global industry in 2016. The more modern trend, especially in the embedded space, is towards hardware-assisted security. Here the aim is to leverage hardware to accomplish security goals that are simply unrealistic in software-only solutions. One example is Trusted Execution Environments (TEE) that provide a secure sandbox to execute security-critical software. TEEs, often driven by ARM TrustZone Technology, are present in the majority of smartphones on the market today. Side-channel analysis (SCA) is a cryptanalytic technique that targets not the formal description of a cryptographic primitive but the implementation of it. Examples of side-channels include power consumption, electro-magnetic radiation, acoustic emanations, and various timings. Attackers then use this auxiliary signal to recover critical algorithm state and, in combination with cryptanalytic techniques, secret key material. This is a young but very active field within security and cryptography stemming from covert channels. SCA is the focus of SCARE. Objectives include the discovery of next generation covert channels, paving the way for novel SCA classes, and extending these to full-fledged end-to-end SCA attacks by identifying specific vulnerabilities in widely-deployed cryptography software libraries such as OpenSSL and hardware-assisted security technologies such as TEEs. In turn, SCARE will deliver a methodology for SCA security assurance: not just development, evaluation, and deployment of acute countermeasures, but bringing SCA into the product life cycle as part of continuous integration.

Keywords: side channel analysis,covert channels,power analysis,timing attacks,cache timing attacks,bug attacks,trusted execution environment,system security,architecture security,software security
Differential demographic behaviour by education and its links with the reproduction of educational inequalities in Europe (DEMOquality)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-02
End date: 2022-01-01
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

In the last decades, social inequalities within countries and the rise in socio-economic differences between European countries have been an increasing policy concern. Education plays a chief role as a resource to fight poverty and to ensure greater social and territorial cohesion, within and across countries, as recognised by the Europe 2020 strategy. Supporting individuals to achieve tertiary education is a necessary policy-target, however, in the long-term, it may not be sufficient to eradicate educational differences across countries. This is especially due to the links between differential demographic behaviours by educational groups and the intergenerational transmission of education. Keeping a comparative approach by country and sex, this project aims at highlighting macro-level consequences of the educational gradient in family formation processes and the transmission of tertiary education from one generation to the next one. To this end, I will use the most recent comparable cross-country individual survey-data (SHARE, GGS), and I will apply advanced statistical techniques (i.e., decomposition and simulation methods) that permit to reconcile micro-macro levels of analysis. This project emphasizes the fact that enacting family policies, which aim to flatten the educational gradient in demographic behaviour, is a possible way to reduce educational differences across European countries. Next, I also emphasize the bidirectional relationship between parent-children generations. On the one hand, I focus on the transmission of education from parents to children and, on the other hand, I refer to (potential) feedback effects of children’s education on parents’ survival. Overall, this project will uncover the connections between the fields of demography and social inequalities. Low fertility and higher life expectancy at older ages, which are the drivers of population ageing, are not necessarily bad outcomes when they may lead to a decrease in social inequalities.

Keywords: education,joint demographic and mobility model
Motion planning technology for autonomous driving (EMP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 3556000.0
EU funding (EUR): 2489200.0
Participants: 1
Project status: CLOSED

Today, more than 90% of road accidents are attributed to human errors. To cope with this, smart technologies are being developed to enable autonomous driving, with the goal of making road traffic safer. With the advent of autonomous driving, less than ten years from now, new business models will appear enabled by autonomous shuttles, robo-taxis, last-mile autonomous delivery vehicles, connected truck platoons and private self-driving cars. One of the major challenges the autonomous car industry faces is the development of embeddable software that, using information from the vehicle sensors, is capable to real-time plan the vehicle motion. Motion planning is the part of the autonomous vehicle operating system responsible for defining the path to follow, avoiding obstacles and ensuring safety, comfort and efficiency. Embotech is a leading supplier of decision-making software developing cutting-edge motion planning technology for autonomous cars. Since 2017 we are working with principal carmakers and Tier 1 suppliers of the automotive industry in proof of concepts of our revolutionary software EMP (Embotech Motion Planner). Using a deterministic approach and physics-based models, EMP generates high-dimensional motion trajectories that enable various self-driving tasks such as valet parking, highway driving pilot and urban driving pilot. EMP provides fully flexible, safe and certifiable motion planning, capable to perform complex manoeuvres real-time on standard automotive grade ECUs. As a SME highly specialized in decision-making technology, our plan is to bring a solution already proven in aerospace and industrial applications, to jointly test it in Level 4 autonomous cars with the support of several automotive industry players. In the market of autonomous driving, growing at a CAGR 19%, and expected to reach €71.3 Bn by 2026, we aim to become the world independent leader supplier of motion planning software for autonomous driving.

Keywords: self driving,automotive,autonomous car,motion planning,autonomous vehicle decision making