Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI-Enabled Data Lifecycles Optimization and Data Spaces Integration for Increased Efficiency and Interoperability (PLIADES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Denmark,Czechia,Germany,Spain,Belgium,Netherlands,Austria,Switzerland,Italy,Estonia
Call: Integration of data life cycle, architectures and standards for complex data cycles and/or human factors, language (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 8999820.0
EU funding (EUR): 8999820.0
Participants: 28
Project status: SIGNED

PLIADES advances the SoA dataspaces reference architectures, towards a step change on the use of data as key enabler of technological advances in AI and Robotics. To this end, PLIADES researches into novel, AI-enabled tools to advance full data life cycles integration, both within and between data spaces. Sustainable data creation methods through data compression, filtering and normalization will be developed, to allow efficient and greener storage in a data-oriented future. Data privacy and sovereignty will be further ensured, through standards and decentralized protocols to protect data-producing organizations and citizens. Alongside, data sharing will be revolutionized through novel AI-based brokers and connectors using extended metadata, shaped through the project’s best practices and domain expert’s knowledge. On top of these, active data discovery services through cross domain AI connectors will allow creating linked data spaces, enabling interoperability between previously disconnected entities, while data quality assessment services will facilitate real time data evaluation. Extended synergies with EU initiatives will be established in order to contribute models, strategies and technologies for a Common European Data Space. Our outcomes will be evaluated in six use cases focusing on direct advancements in key AI and Robotics technologies for everyday use, oriented around multiple data spaces; mobility, healthcare, industrial, energy and green deal. Our use cases provide a challenging validation suite involving vast heterogeneous data creation, management and sharing while addressing full data lifecycles in multiple major domains. Through the developed ecosystem, CCAM and ADAS/AD car technologies will be enhanced, HRI for robot operators and healthcare patients will be reshaped, while further advanced, integrated data spaces will be deployed in the healthcare, manufacturing and green deal sectors aiming to reduce carbon footprints and shape a greener future.

Keywords: data space interoperability,data lifecycle integration,ai boosted data brokers,sustainable data creation,dataspaces to advance ai and robotics,healthcare,manufacturing,ccam and adas ad
Cortico-striatal circuit assembly in Fragile X Syndrome (FXSdev)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the main monogenetic cause of autism spectrum disorder. FXS is caused by the epigenetic inactivation of the FMR1 gene during the first trimester of gestation. FMR1 encodes for the fragile X mental retardation protein (FMRP), which regulates the transport and translation of mRNAs involved in brain development. Already at 6 months of age, FXS infants display structural alterations in several brain areas, including the fronto-striatal circuit, suggesting an altered neural network assembly during fetal brain development. Structural anomalies in the fronto-striatal circuit may underlie symptoms that strongly impair the life of FXS patients, such as attention deficit, hyperactivity, stereotypic language and motor behavior, and problems with impulse control. This project aims at understanding the causal factors of the altered assembly of the fronto-striatal circuit in FXS fetuses. To achieve this goal, we will generate human cortical and striatal brain organoids from FXS naïve induced pluripotent stem cells, and assemble these organoids into cortico-striatal assembloids. The resulting in vitro model will be used to conduct research in two directions. First, it will allow us to recapitulate cortico-striatal circuit assembly in FXS, identifying potential defects in axon growth and guidance, neuron morphology and neural connections. Second, we will investigate the molecular causes of these defects, in particular how the absence of FMRP affects the expression of proteins involved in the assembly of the FXS cortico-striatal circuit. These studies will make it possible, for the first time, to spatiotemporally follow the pathological events that cause FXS, both at the cellular and at the molecular level, and they will pave the way for the identification of new therapeutic strategies to prevent the development of the disease.

Keywords: fragile x syndrome,brain organoids and assembloids,neural network assembly,cortico striatal neural circuit
Intrinsically disordered proteins in health and disease: mechanisms, molecular context and opportunities for drug discovery (IDPro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,Denmark,France,Italy,Hungary,Germany,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2965309.71
EU funding (EUR): 2741990.4
Participants: 15
Project status: SIGNED

Proteins dictate virtually all cellular processes. To do so, precise 3D-structures that fit to their binding partners are exploited. However, up to 40% of the human proteome exist in disordered, dynamic ensembles of states mandatory for function. These so-called intrinsically disordered protein and regions (IDPs) play crucial roles in most aspects of life. They mediate tens of thousands of protein-protein interactions involved in cell signaling, scaffolding, transcription, membrane-less organelles and more. While the pivotal role of IDPs in biology is recognized, most of their functions remains unexplored. The time is now ripe for the next frontier, decomposing protein-protein interactions involving IDPs on a large scale. Importantly, IDPs are emerging drug targets for treating complex diseases: cancer, neurodegenerative disorders, metabolic syndromes and viral diseases, afflicting an ageing European population. The evolving field demands a new generation of experts to take the lead in developing different types of drugs targeting IDP interactions. This MSCA DN project aims to educate ten doctoral students within this evolving field by tackling outstanding questions. In particular, we will delineate the role of context in interactions involving IDPs, including flanking regions, folded domains, disease-related mutations, and aberrant cellular signaling and also design peptide-based ligands based on disordered regions that can potentially be further developed into drugs or molecular probes. A team of 14 established scientists from seven academic institutes and five companies, with excellent experience in supervision and cutting edge knowledge on IDPs and experimental and computational techniques will form IDPro. IDPro constitutes an exceptional network where the PhD students can mature and obtain scientific excellence in academic as well as non-academic settings. IDPro will strengthen the future academic and biotech labor force of the European union.

Keywords: intrinsically disordered proteins disease mutations kinases protein protein interactions
Narratives, Myths, and Religious Rituals in Football under the Franco Regime and the Shifting Powers in Argentina (1939-1976) (FAITHBALL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Argentina,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-16
End date: 2028-09-15
Duration (months): 36.0
Total project cost (EUR): 272351.16
EU funding (EUR): 272351.16
Participants: 3
Project status: SIGNED

The FAITHBALL project explores the intersection of football, politics, and culture in Spain and Argentina from 1939 to 1976, focusing on the Franco and Perón regimes. Football, often seen merely as a sport, was harnessed as a tool of propaganda and diplomacy during this period, shaping national identities and international relations. The project aims to bridge the gap in existing research by providing a comparative analysis of how football was used to reinforce political narratives and enhance diplomatic ties between these countries. In addition to examining legislative and media portrayals, major football events, and their impact on national and regional identities, the FAITHBALL project will delve into the social and cultural dimensions of football through the study of rituals, myths, and narratives. Football in both Spain and Argentina was not just a game but a powerful cultural phenomenon, woven into the social fabric through specific rituals and myths that reflected and reinforced the political and cultural climate of the time. By analyzing how football rituals and collective myths were constructed and propagated, the project will uncover how these elements contributed to the shaping of national and regional identities and influenced societal values and collective memory. Through an interdisciplinary approach, combining historical, sociological, and digital humanities perspectives, it will develop a comprehensive framework to understand football's role in political and cultural dynamics. Throughout the project, the following deliverables will be produced: a monograph, several academic articles, a podcast, an open-access database and an interactive digital map designed to facilitate further research and provide new insights into the role of football in shaping national and international relations.

Keywords: football history national identities spanish history latin american history
A New Perspective on City Logistics: Concepts, Theory, and Models for Designing and Managing Logistics as a Service (GoodMobility)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Türkiye
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Several social, economic, and technological trends are coming together to revolutionize the way people, products, and services are brought together. Goods are gaining more mobility with drastic implications for cities. The current city logistics (CL) paradigm, which does not consider the mobility of goods a public need, limits our capacity to understand and respond to the challenges and opportunities brought by this profound change. Taking a different perspective, GoodMobility proposes to replace the techno-business-centric smart thinking with network-centric wise logistics that takes the public value as the primary goal and envisions setting up a logistics web with the required infrastructure (hardware) and operating procedures (software) to establish logistics as a service (LaaS). The first objective is to develop public value as a measurement system to assess and guide CL planning and management, which will be achieved with an iterative process, combining multi-criteria decision making, sustainability analysis, simulation, and optimization. The second objective is to develop the principles, models, and tools for LaaS infrastructure design. Novel network optimization methods will be developed for designing the hardware of LaaS to provide orders of magnitude efficiency gains and influence the stakeholder activities to maximize public value. The third objective is to develop a theoretical framework and models for the operating procedures of LaaS, introducing the logistics markets to ensure efficiency and reliability and secure public value in matching logistics demand and supply. Learning-based optimization methods will be developed to manage logistics markets. If successful, GoodMobility will lay the foundations of a new theory of CL with significant scientific and practical implications. The novel ideas, concepts, and methodologies will open up new research perspectives in transport and logistics with far-reaching social, economic, and environmental consequences.

Keywords: transportation,logistics,network optimization,market design,online algorithms,integer programming,discrete choice models
Ethics and Moral Life in the 18th Century: A New Take on Early Modern Ethics (18ETHICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1463694.0
EU funding (EUR): 1463694.0
Participants: 1
Project status: SIGNED

Early modern ethics has so far been investigated with regard to the debates on the foundations of morality, moral knowledge and the status of moral principles. Despite their achievements, the main limit of previous studies is that they have largely disregarded the distinctive purpose of ethics in that age, that is, to provide guidance about specific moral issues. Even the discussion on the abstract topics on which most studies have focused was in fact sustained by the purpose of providing the appropriate tools for leading a good life. This applies especially to 18th-century moral philosophers, who devoted most of their efforts to an all-encompassing examination of the most significant demands in all areas of morality, presenting themselves as moral experts. In sharp contrast to previous scholarship, the present project centres on that underlying ambition. The focus will be the raison d’etre of 18th-century treatments of morality, that is, to provide practical guidance. Thereby the project intends to re-orient the studies on the history of early modern ethics. The proposed research will be highly innovative both (1) because of its topics and (2) because of its approach. (1) The project gives prominence to neglected clusters of issues that defined the main concern of 18th-century moral philosophers: the duties to oneself and others, the moral relevance of our conduct towards animals, the extent of disagreement about moral questions. (2) Unlike most current scholarship, the investigation will have not a monographic, but a thematic and comparative approach, examining different takes on the same issues. On both sides, the project has in view an impact that goes well beyond the mere scope of the proposed research, by suggesting a much broader perspective on a distinctive contribution of philosophy to European culture, which offers insights on currently much discussed issues about the status and aims of ethics.

Keywords: history of moral philosophy,duties to oneself,duties to others,moral experts,pufendorf,kant
Horizon Europe Office in Ukraine as the key National Contact Point (NCP) (HEOinUA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Euratom
Destination: Euratom
Action type: Coordination and support actions
Countries involved: Ukraine
Call: Horizon Europe Office in Ukraine as the key National Contact Point (NCP) (HORIZON-EURATOM-2023-UKRAINE-IBA, 2023)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 1749362.5
EU funding (EUR): 1749362.5
Participants: 1
Project status: SIGNED

The agreement with Ukraine associating it to Horizon Europe and Euratom R&T Programmes has been in force since 9 June 2022 and represents a key instrument to support Ukrainian researchers and innovators in the context of ongoing military aggression by Russia. Ukrainian entities can participate in the programmes on equal terms with entities from EU Member States. Ukraine does not have to contribute financially for years 2021 and 2022 and there is a general encouragement across the Horizon Europe Work Programme to create opportunities, where possible, for the affected persons and entities of Ukraine. At the same time, Ukraine’s R&I capacity, both at institutional and individual levels, is at risk in view of public R&I budget cuts and destroyed research infrastructure. According to the latest survey, out of more than 2000 Ukrainian scientists, 38% have been forced to relocate internally, 15% have left abroad and three quarters are struggling to carry on their work. In relation to other associated countries, Horizon Europe Offices exist in Georgia (Executive Agency of the Ministry) and Turkey (the Scientific and Technological Research Council (Tubitak) and represent useful tools to facilitate and/or improve these countries’ in the Horizon Europe programme. A grant to identified beneficiary is an appropriate implementation modality for this action as it will reinforce the key R&I public institution of Ukraine - the National Research Foundation of Ukraine (NRFU) – in view of the ongoing military aggression by Russia and its far-reaching impacts on the R&I sector in Ukraine. The NRFU is the only public institution that runs competitive R&D calls in Ukraine.

Keywords: national contact point
Hybrid Zn-Based Membrane-Free RFBs with Eutectic Electrolytes for Enhanced Stability and Performance (Zn-MFreeRFB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Efficient energy storage is crucial for integrating renewable energy sources and ensuring climate security. Redox flow batteries (RFBs) offer a scalable solution but are currently hindered by high costs and limited ion exchange membranes. To address these limitations, biphasic membrane-free redox flow batteries (RFBs) have received significant attention. However, it is important to note that this membrane-free technology is still in its early research stages and presents several challenges such as self-discharge, low Coulombic efficiency, and reduced state of charge. To address this, hybrid Zn-based biphasic membrane-free RFBs have emerged as a potential solution. These systems utilize a metal-based anolyte (Zn metal anode) that remains separate from the catholyte, thereby mitigating self-discharge and enhancing coulombic efficiency. However, existing hybrid Zn-based membrane-free RFBs predominantly use aqueous electrolytes for the Zn metal anode. This approach presents several issues, including dendrite formation, undesired side reactions such as hydrogen and oxygen evolution, a restricted voltage window, and surface passivation problems. To overcome these challenges, this research proposes the development of a hybrid Zn-based membrane-free RFB utilizing a nonaqueous biphasic electrolyte system. By employing a eutectic solvent for the Zn metal anode and a nonaqueous solvent for the redox-active cathode materials, this approach aims to reduce dendrite formation, eliminate unwanted side reactions, and extend the electrochemical stability window. This innovative system promises to enhance both efficiency and energy density, addressing the limitations of both aqueous and nonaqueous systems. Conducted at IMDEA Energy under the guidance of Dr. Rebeca Marcilla, the project will focus on developing advanced electrolytes, fabricating the biphasic system, designing high-voltage batteries, and evaluating performance.

Keywords: biphasic eutectic electrolytes membrane free redox flow battery zn metal
Enzymatic cascade biotransformations in digitally manufactured continuous-flow bioreactors (FlowBioCat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-16
End date: 2025-01-15
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Within Industrial Biotechnology, applied biocatalysis is poised to transform drug discovery and development by pharmaceutical industry. Enzymes as catalysts, allow for synthetic chemists to generate molecular complexity avoiding costly and time-consuming protection and deprotection steps. However, the high cost associated to their use, especially if a co-factor is required, the low substrate tolerance and productivity and the difficulties for scale-up, strongly limit the industrial uptake of these processes. The combination of enzyme immobilisation and continuous flow (CF), offers an opportunity to overcome these limitations. Enzymatic performance and recyclability can be dramatically improved by immobilisation and generic problems such as low productivity and substrate inhibition effect can be solved using CF. During the last years, enzymes have been most commonly immobilised in packed bed reactors. However, the very low flow rates required to achieve full conversion, decrease the mixing and make the system look closer to a batch reaction (with its generic problems). Here we aim to address these limitations through the design and manufacture of 3D Printed (3DP) reactors that combine optimised mixing at low flow rates, with tailored surface modification techniques with ionic liquids (ILs) for stable biocatalyst preparation and higher number of active sites. 3DP facilitates the generation of complex geometries in a variety of materials based on ILs, tailored to optimise enzyme stability. The aim of this proposal is to integrate chemical engineering (3DP continuous flow reactors) and biocatalysis (stable and recyclable immobilised enzymes) to develop more efficient biotransformations in flow, easy and effective immobilisation of enzymes and significantly promote sustainable development of IB. It will have a direct impact in the EU from an environmental, economic and social perspective, lowering drug prices, facilitating distributed production and reducing waste.

Keywords: biocatalysis,continuous flow,3d printing,enzymatic cascades,ionic liquids