Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification of risk factors for the development of colorectal cancer and / or premalignant lesions using Big Data tools and Artifical Intelligence for early cancer detection (AMX DATA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2020-10-01
End date: 2021-12-31
Duration (months): 15.0
Total project cost (EUR): 185000.0
EU funding (EUR): 129500.0
Participants: 1
Project status: CLOSED

Founded in 2010, AMADIX is a leading molecular diagnostics company focused on liquid biopsy, developing innovative diagnostic tests for early cancer detection in blood. The mission of the company is extending people lives, developing disruptive technologies to detect the tumor years in advance, before the symptoms appear. The company’s products are oriented to non-invasive early cancer detection, avoiding the complications of existing invasive procedures, as tumor biopsies in colon, lung and pancreatic cancer. The application of Advanced Data Analytical tools in healthcare has a lot of positive and also life-saving potential. When speaking about data, we are referring to the vast quantities of information created in digitization of medical documents, and that could be consolidated and analyzed applying specific technologies. Aligned with our mission, AMADIX continues to go further, not only working at a molecular level but also exploring possibilities that clinical records and patient data offer (particular conditions, lifestyle, living area…). We are registering, processing and analyzing data through the latest Artificial Intelligence (AI) and Advanced Data Analytical Tools, in order to identify new risk factors, to develop predictive models which will help us anticipate hidden underlying cancer risk factors, treat patients in time and help improve the quality of life and survival of cancer patients. So, as an overview, the objective of AMX DATA is identifying risk factors in colon, lung and pancreatic cancer based on medical history, individual habits and image analysis to incorporate new risk cancer factors - in combination with our blood test gene signature - into our algorithms using Big Data tools and Artificial Intelligence. The development of this disruptive project requires the recruitment of an Innovation Associate with a multidisciplinary set of skills combining expertise and knowledge in cancer diagnostics and data analysis tools.

Keywords: cancer,colon,adenomas,big data,artificial intelligence,diagnostic,blood,liquid biopsy
High-throughput vibrational fingerprinting by nanoplasmonics for disease biology (VIBRANT-BIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 2562325.0
EU funding (EUR): 2562325.0
Participants: 1
Project status: CLOSED

Devastating diseases such as Alzheimer’s, Parkinson’s and various cancers are still without cures, continue to undermine the quality of life for millions of people and impose significant economic burdens. Misfolded toxic proteins constitute the microscopic basis of these diseases, but little is understood about their structure and biological function. This is due the fact that current technologies are severely limited for molecular-level identification of protein structures and high-throughput analysis of biomolecular interactions. VIBRANT-BIO aims to introduce breakthrough mid-infrared spectroscopy technologies, including the first spectroscopic microarray, to overcome the limitations of current methods by enabling complete profiling of biomolecules from identification of their structure and composition to their biological function. To achieve its ambitious goals, VIBRANT-BIO will exploit plasmonics and newly discovered two-dimensional nanomaterials such as graphene and explore the ultimate limits of light-matter interaction to demonstrate biosensors with extreme sensitivity, throughput and functionality, well beyond the state-of the art. It will innovatively integrate nanoplasmonics with advanced photonics and bioanalytical tools to dramatically enhance sensor performance and introduce new functionalities. The proposed technologies will be applied to study toxic amyloid-beta proteins and their interaction with lipid membranes for understanding the molecular mechanisms underlying Alzheimer’s disease. VIBRANT-BIO will contribute to define the road-map for next generation biosensor and spectroscopy technologies through interdisciplinary research covering physics, engineering, chemistry and biology. The capability of the proposed systems to analyze a broad range and ultra-low quantities of molecules and chemicals provides a general-purpose toolkit that can impact numerous fields such as bioscience, material science, pharmaceutical industry, and homeland security.
Urban air temperature and wind speed variability: Empirical modeling to improve planning applications (Urb-TWin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-04-15
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Climate change induces warmer summers and more frequent and intense heat waves, increasing human mortality and energy demand for cooling purpose. This is particularly critical in urban areas where climate variables such as temperature, humidity, wind and radiation are modified by the urban morphology, the lack of pervious soils and the human activities. While the urban population is likely to grow, it is urgent to make cities cooler. The overall goal of my project is to determine the urban fabric characteristics (mainly the morphology, vegetation cover and land-type) affecting the air temperature and the wind speed spatial variability. This new knowledge will be integrated in the Geographical Information System software QGIS in order to make it easily available to researchers working with urban issues as well as urban planners. First, empirical models will be developed to relate observed air temperature and simulated wind speed values to geographical indicators characterizing an observed or a simulated location (e.g. distance to building facade, vegetation or building density, etc.). Second, these models will be integrated in the QGIS software and thus will be available for interdisciplinary research purposes. Third, I will investigate the coupling of the urban climate models with energy models devoted to building energy estimation or solar energy production which are developed by the University Savoie Mont-Blanc (USMB - partner organization). The models developed during Urb-TWin will be useful for the urban climate research community since they could be used to speed up CFD simulations used in urban climate models. Moreover, they will also be available for urban planning applications from the widely known QGIS plat-form. Last, thanks to the Urb-TWin training and secondment, I will also increase my probability to get a permanent position as leader of an urban climate research axis at the partner organisation in the next years.

Keywords: outdoor thermal comfort,building energy
Zero emission livestock project (ZELP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are 1.5 billion cows in the world, and they are huge contributors to global warming. Methane emissions from cows belching represent the carbon equivalent of the whole of the transport industry put together. Due to the way it traps heat, methane is 85 times worse for global warming than carbon dioxide. ZELP created a patent-pending wearable device in the form of a nose ring to drastically reduce the impact of livestock’s methane belch emissions. Today it is only a prototype, but tomorrow it will to help reduce the environmental impact of the methane emissions by a factor of 85!
Functional circuits mediating the effects of reward value on perception within and across sensory modalities (RewardedPerception)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-04-30
Duration (months): 75.0
Total project cost (EUR): 1444079.0
EU funding (EUR): 1444079.0
Participants: 1
Project status: CLOSED

Our perceptual system needs to maintain a balance between selectivity and sensitivity, so that redundant information is dismissed, but novel and important information does not go unnoticed. Selective attention and reward value are among mechanisms that adjust this balance, by exerting top-down control over bottom-up sensory processing. Excessive reliance on top-down signals has been suggested to underlie pathologic conditions, such as hallucinations. In contrast, controlled boosting of top-down signals is a potential tool to rehabilitate impaired sensory functions. Despite their importance, key aspects of top-down and bottom-up interactions have remained unknown: We do not know how abstract, non-sensory signals, such as reward value, could exert specific sensory effects; it is unclear how they are transmitted across sensory modalities and what the underlying neural mechanisms are. Here, I will try to provide answers to these questions by combining behavioural testing, neuroimaging, and non-invasive brain stimulation techniques in humans. I will use a novel approach, where abstract reward value of a stimulus is linked to a sensory modality label. This enables me to trace how value-driven, top-down signals are communicated to sensory areas and how they impact on different aspects of perception: from detection of external signals to perception of illusory associations. Using brain imaging techniques, I will distinguish between regions where the sensory modality label is represented, and regions where reward value signals are coded, regardless of their sensory modality. Finally, I will test whether non-invasive perturbation of regions containing sensory modality labels impairs perception in the respective modalities, thereby testing if these regions play a causal role in selective top-down interactions. This project will therefore provide a mechanistic understanding of functional circuits that underlie the effects of reward value on sensory perception in humans.

Keywords: sensory perception,reward value,top down modulation,brain imaging
ERA Chair for emerging technologies and innovative research in Stretchable and Textile Electronics (STRENTEX)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Serbia
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2475500.0
EU funding (EUR): 2475500.0
Participants: 1
Project status: SIGNED

The motivation behind this Project is to create a point of excellence of the Faculty of Technical Sciences, University of Novi Sad (FTN), Novi Sad, Vojvodina, Serbia, to continuously advance state-of-the-art research, technological innovation and contribution to broader social goals, in the field of Stretchable and Textile Electronics. The Project is set in the framework of the ERA Chair action to simultaneously reinforce the research potentials of the FTN and to create cutting-edge dynamic and sustainable research environment. With the support of the network of existing international/regional/national partners, SMEs and stakeholders, research results will be fruitfully exploited and provide a move from flexible/bendable to stretchable products, defined by the needs of society. These products with a high future market potential, such as human monitoring patches, sensors in baby slings, theranostic dressings, will enable a move from “technology push” to “market pull” and will facilitate involvement of the ERA Chair into “Industry 4.0” revolution. STRENTEX project envisages the following activities: (1) ERA Chair establishment – ERA Chair holder appointment and employment of his/her team members; (2) Implementation of structural changes in FTN, for sustainable excellence; (3) Raising research profile of the FTN and its staff, thanks to ERA Chair; (4) Boosting FTN’s innovative capacities and capabilities; (5) Dissemination, communication and exploitation activities. Thanks to this Project, disparities in terms of research and innovation performance between Serbia and innovation leaders in EU will be significantly decreased. Far-reaching effects of the STRENTEX will be creation of world-class working environment and favourable eco-system for flourishing centre of excellence and innovative start-up companies, strengthening of the Serbian and European economy.

Keywords: stretchable electronics,textile electronics,flexible electronics,application in biomedicine
A new tumor suppressor role for RSK2 in hepatocellular carcinoma (HepatoRiSK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: TERMINATED

Hepatocellular carcinoma (HCC) ranks third in cancer mortality worldwide. In spite of this, effective treatment options are limited, partly due to a poor understanding of the molecular basis of HCC, which hampers development of targeted therapies. Recently, cancer genome sequencing mapped the landscape of genetic aberrations in HCC and unexpectedly revealed the kinase RSK2 as the most frequently mutated gene in the RAS-RAF-ERK pathway. I hypothesize that RSK2 is a tumor suppressor in HCC by acting as a feed-back inhibitor of the RAS-ERK pathway, since I find that RSK2 mutations are nearly all loss-of-function and that RSK2 loss potently activates ERK kinases in liver cells. The goal of this proposal is to functionally establish RSK2 as a novel and important tumor suppressor in HCC and identify the mechanism(s) whereby RSK2 may feed-back inhibit the RAS-ERK pathway to promote this cancer. This will be achieved through modelling RSK2 loss in liver cells in vitro and in mice. Among other approaches, I will model RSK2-dependent HCC development by mutating genes found co-mutated with RSK2 directly in the adult mouse liver via hydrodynamic tail vein injection of CRISPR/Cas9 reagents, which may cause HCC within months. I will subject cells and mouse models to mechanistic biochemical and phenotypic studies to elucidate the role and mechanism of RSK2 as a tumor suppressor in HCC. Key findings will be validated in HCC patient samples. The work will be performed in the context of my new role as assistant professor in the host lab, where I will be given formal supervision and management responsibilities. The work combines my postdoc experience in cancer genetics with my host´s beyond-state-of-the-art CRISPR/Cas9 genome editing techniques. Altogether, this fellowship has the potential to uncover new mechanisms for targeted intervention in HCC. Furthermore, it will be an important stepping stone for me towards an independent research career.

Keywords: cancer biology,rsk2 kinase,crispr,cas9 genome engineering,hepatocellular carcinoma
Locomotor issues in Parkinsonian's Mesencephalic Locomotor Region and Subthalamic nucleus (LINKERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Parkinson disease (PD) is the most common movement disorder. Dysfunction of basal ganglia circuits in PD leads to characteristic motor deficits including bradykinesia, with hypometria and reduced EMG activity, tremor, and frequently gait disorders with start hesitation or freezing of gait (FOG) associated with increased falling. On the one hand, there is a large literature on the postural adjustments during gait initiation and the biomechanics of ongoing gait in healthy and patient populations. On the other hand, neuronal recording in the pallidum, subthalamic nucleus (STN), substantia nigra pars reticulata (SNpr) and mesencephalic locomotor region (MLR) demonstrate activity related to movement and locomotion in rats, cats, primates and humans. DBS, particularly STN- and MLR-DBS, can effectively alleviate postural and locomotor deficits in PD, although the neural mechanisms and the precise role of each structure in locomotion is still matter of debate. The aim of this study is to characterize the association between STN and MLR neuronal activity and the biomechanical parameters of locomotion and gait initiation. I will characterize these associations in PD patients using neuro-muscular, neuro-kinematic and neuro-neuronal (STN-STN, MLR-MLR) coherence in different locomotor paradigms under different treatment conditions. This study will make an important contribution to a poorly studied but important aspect of motor control in PD. From a knowledge transfer point of view, it will provide important information to clinicians and researchers using DBS to ameliorate postural difficulties and FOG. From an interdisciplinary point of view, it will help neurologists to refine diagnosis as well as foster the core of knowledge and help targeting new avenues of treatment to rehabilitation professionals involved in the non-invasive treatments of PD.

Keywords: locomotion,coupled biomechanics and neurophysiology signals
True digitalisation of all transactional administration in the trade value chain through smart legal contracts. (QuidProQuo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

QuidProQuo is an ecosystem of intelligent, integrated platforms and services that enable true digitalisation of the trade value chain. We are starting with trade settlements, payments and finance. QuidProQuo removes all low-value transactional administration from the trade value chain for any enterprise. This can save up to 12% of their revenue. It also provides trade finance for SMEs. The trade finance market is worth $9t annually, however there is an unmet demand of $1.6t. We have completed over 60 customer discoveries with enterprises of various sizes and industries. These demonstrated a clear demand for QuidProQuo. We are now working towards identifying pilot customers. QuidProQuo will be sold to enterprises involved in trade settlements and finance, and other stakeholders. We will charge a 1% commission to trading enterprise on the value of payments. Our first commercial targets will be trading firms in the EU and the US where we currently have a presence We have a world-class team drawn from banking, law, technology, and business management, so are uniquely positioned to deliver our vision. Key partnerships secured: Launchbadge for with turn-key development capacity for our distributed ledger technology. Projected sale volume in 3 years: €600m cumulative gross profit 3 years following commercialisation. ROI: 120x the investment of €5m needed to reach commercialisation.

Keywords: smart legal contracts,digistalisation,trade finance,supply chain finance,transaction settlement,internet of things,computerised ai credit scoring,distributed ledger technology,blockchain
PRS, an industrial repair system for large series of reusable plastic articles in a circular economy (PRS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 2345364.5
EU funding (EUR): 1641755.15
Participants: 2
Project status: CLOSED

In Europe, there are 1.9 billion items of plastic Returnable Transport Packaging (RTP), which are plastic pallets and crates that are used across various sectors, including the automotive, beverage, logistic and pooling services. Also in Europe, the number of plastic street containers for Municipal Solid Waste (MSW) exceeds twenty million. The average lifetime of these articles ranges from five to ten years. When they break, these items are discarded and replaced with new ones. Discarded items have three destinations: recycling, incineration or as landfill. The owners of these plastic elements barely consider the possibility of their repair. At Plastic Repair System, we have developed and patented an industrial technology for the repair of reusable plastic articles, which allows their use with total confidence and guarantees, while the cost of repair is less than one third of the new value of the same article. Repairs undertaken with PRS technology have been analysed by independent laboratories that have certified that PRS recovers 100% of the object's functionality and at least 98% of its original strength. Practical feasibility has been demonstrated in a Phase 1 SMEI project: as a starting point, we have successfully tested our technology with some product references for 6 multinational companies. PRS2011 is one of the few circular economy solutions in EU with a direct and immediate positive impact in the environment: RTPs reusing is much better and cheaper than recycling. The interest and novelty of this project has been recognized by the EU Commission: PRS awarded in the EU Business Awards Environment, Product&Services (14/11/18). We have received also interest from four European venture capital funds focused on innovative companies in the circular economy. Project Phase 2 will allow us to complete our technical solution and reach agreements with partners for international expansion.

Keywords: reuse,plastic,repair,environment,carbon footprint,pallet,crate,container,reusable,returnable transport packaging,circular economy