Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Customized Surface-Engineered “Nanoglue”: Unlocking Ultrasound-Triggered targeted delivery of CRISPR/Cas complex for Glioblastoma (CRISPRGlue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 3
Project status: SIGNED

Glioblastoma multiforme (GBM), constituting 50.1% of CNS tumors, is the most frequent malignant brain cancer with a median survival of 14.6 months, highlighting the urgent need for more effective treatment strategies. The rise of effective gene therapies especially CRISPR/Cas (“clustered regularly interspaced short palindromic repeats/associated protein 9”) based gene editing technology has sparked optimism for treating GBM. Given the ongoing challenges with CRISPR-Cas gene therapy, such as effective delivery across the blood-brain barrier (BBB), off-target effects, and immune responses associated with Cas9, this research proposal (CRISPRGlue) aims to develop "nanoglues," a novel class of engineered nanogels for targeted delivery of CRISPR tools followed by ultrasound triggered release to address GBM treatment challenges at a European level. The gene editing efficacy of the CRISPR/Cas tools delivered by “nanoglues” will be preliminary investigated as a “proof of concept” by knock-down approach with GFP expressed U87MG cell line followed by targeting EGFR genes which are highly overexpressed in GBM sites. The project unites a dynamic researcher, Dr. Soumen Ghosh, with expertise in synthetic organic chemistry and protein science, alongside POLYMAT, an innovative institute focused on biomedical solutions utilizing nanogels for the controlled release of the CRISPR/Cas9 complex. Prof. Marcelo Calderón, the host supervisor, is a globally recognized researcher leading the “Responsive Polymer Therapeutics Group (RPTG),” a top team specializing in drug delivery using nanogels (NGs). The multidisciplinary expertise required for CRISPRGlue will be complemented by the Smart Bio-Interfaces group led by Prof. Gianni Ciofani. CRISPRGlue will advance the researcher’s career in both academic and non-academic fields by developing non-viral gene delivery systems to facilitate curative gene editing, empowering him to drive the translation of laboratory findings to pre-clinical trials.

Keywords: non viral delivery nanogel glioblastoma molecular glue crispr cas9 gene editing
Algorithms, Security and Complexity for Quantum Computers (ASC-Q)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2028-06-30
Duration (months): 72.0
Total project cost (EUR): 1499798.75
EU funding (EUR): 1499798.75
Participants: 1
Project status: SIGNED

As progress is made in implementing quantum computers, the question is looming: What will we do with them? This proposal is concerned with the theoretical computer science aspects of this question. Part of this question is concerned with quantum algorithms (WP1). We know of several examples of quantum algorithms with large speedups over the best known classical algorithms, such as Shor's poly-time integer factorization algorithm. While this is evidence that quantum computers will be useful once built, it does not tell us what quantum computers will be used for in practice (probably not much factoring). To ensure that quantum computer users are best able to make use of them, we will focus on developing general techniques for the design of quantum algorithms that can be easily applied by subject-matter experts in different fields to the problems that interest them. We will also consider the constraints of early quantum computers in our algorithm design. First, we would like to understand how the limited memory of early quantum computers will impact what they can do. Some of the most important techniques for designing quantum algorithms are already well-suited to the study of space-bounded computation, and we will generalize and improve these in WP1. To complement this, we will study lower bounds and complexity (WP2), focusing on space-bounded complexity classes, which have many relationships with other complexity classes. Second, since most early users will have to delegate their quantum computations, we would like to understand which quantum algorithms can still be used in various delegated or multiparty settings where some type of security is a consideration. We take the novel approach of using a quantum algorithmic model called span programs to design secure quantum computing protocols (WP3). It turns out that space-bounded models and secure quantum computation are very much related, and understanding this relationship is what ties this proposal together.

Keywords: quantum algorithms,quantum walks,span programs,quantum complexity theory,space bounded quantum computing,secure quantum computing
Valorisation of agro-industrial waste to obtain zeolite-based composite materials and their use in environmental remediation and biofuel production (VALZEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Italy,United Kingdom,Cuba,Ireland
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 969942.86
EU funding (EUR): 883200.0
Participants: 9
Project status: SIGNED

In EU, an average of 3.1 million tons of paddy rice is produced (ca. 450.000 ha). Around 80% of the EU rice production takes place in Italy and Spain, with a further 12% in Greece and Portugal. Globally, 750 million tons of rice husk (RH) are yearly produced, and it is estimated a continuous increase of 1.1% each year. Each ton of rice can produce 20% of RH, that must be eliminated since it accumulates in the environment due to its low degradability. RH generates 18-20% of RHA through a combustion process. The inadequate deposition of RHA pollutes the environment and deteriorates the respiratory system of humans and animals. During RH incineration, the burnt ash can spread into a large area facilitated by air, causing environmental pollution. According to these figures, large volumes of RHAs with low density are becoming a major challenge to the surroundings of dumping environment and dump fill areas. VALZEO intends to employ RHAs as raw supplies to produce composite materials based on hierarchical zeolites modified by metal oxide nanoparticles (MON) and metal-organic framework (MOF) materials with a double purpose, the removal of pharmaceuticals, pesticides, dyes and microorganisms in water, and the catalytic production of biodiesel. To address such challenge, VALZEO will promote the exchange of researchers from participating institutions to enhance the exchange of knowledge, best practices, know-how, innovative ideas, experience, cooperation, and culture of work. VALZEO will foster, improve and develop permanent international and inter-sector collaboration between academic research centers, and private sector, enhancing the exchange of knowledge, best practices, know-how, innovations, experience, mutual cooperation and culture of work at different regions and countries (ES, IT, UK and CU) through a series of scheduled secondments.

Keywords: zeolites,water treatment,biodiesel production,rice valorisation
Transcriptional Engineering of Hematopoietic Stem Cells using CRISPR (HSC-CRISPR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499923.0
EU funding (EUR): 1499923.0
Participants: 1
Project status: SIGNED

Hematopoietic stem cells (HSCs) reside in the bone marrow where they throughout life sustain continuous blood production through a controlled balance of differentiation and self-renewal. Transplantation of HSCs from a healthy person can replace a defective hematopoietic system of a patient thereby curing the patient for life. HSCs have found increasing therapeutic application, e.g. in hematologic malignancies and hematopoietic genetic disorders. This applies not only to the allogeneic transplantation setting but also to the autologous setting where advances in genetic engineering technologies have enabled autologous gene therapies. However, major challenges remain in both settings pertaining to the scarcity of HSCs, as well as the cells being partially refractory to precise gene correction. In this research proposal, I will address these challenges by leveraging the unique power of repurposed CRISPR/Cas systems for precise transcriptional manipulation of HSCs. In these systems, the normal DNA-cleaving ability of the Cas9 enzyme is disabled (dCas9) while transcriptional activators or inhibitors are fused to dCas9. By targeting the dCas9-effector proteins to transcriptional start site regions by sgRNA programming, gene transcription can be activated (CRISPRa) or inhibited (CRISPRi). Complex transcriptional engineering is readily achieved using multiple sgRNAs and orthogonal CRISPR systems for simultaneous CRISPRa and CRISPRi. I will apply these technologies to investigate and enhance therapeutically relevant HSC pathways, namely homologous recombination for precise gene editing, self-renewal, and bone marrow homing. These biological phenomena have previously been studied with techniques that do not have the same elegant properties and therapeutic relevance as CRISPRa/i. With this new state-of-the-art method for precisely controlling gene expression, I will study and manipulate genetic pathways to overcome long-standing challenges in HSC therapies.

Keywords: crispra crispri crispr hspcs cd34 stem cells
Towards Sustainable and High-Performance Sodium-Ion Batteries: Development of Anode Materials Based on Binary Metal Phosphides Confined in Multi-Doped Carbon Matrices (SUS-BATT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2028-01-31
Duration (months): 30.0
Total project cost (EUR): 335710.8
EU funding (EUR): 335710.8
Participants: 2
Project status: SIGNED

The project aims to advance sodium-ion battery (SIB) technology through the development of innovative, sustainable electrode materials. Its primary focus is on creating binary carbon-confined metal phosphide (MPs@C) nanoparticles to be used as efficient anode materials for SIBs. This initiative addresses 2 critical challenges, the sustainable fabrication of electrode materials and the enhancement of their electrochemical performance. The innovative fabrication technique involves the pyrolysis of heterometallic organophosphine frameworks (Organic P-ligands linking two types of metal ions within a framework structure) as templates to produce binary MPs@C, avoiding the environmentally hazardous phosphorization step associated with the traditional methods. The project leverages an interdisciplinary approach, combining the expertise of the postdoctoral fellow in synthetic inorganic chemistry, the knowledge of the host supervisor in electrochemistry and nanostructured materials, and the experience of Glantreo, an industrial partner specializing in custom nanomaterials development. The research plan includes close collaboration between academic and industrial partners, Glantreo Ltd. (6 months of non-academic placement), to ensure practical application and industry relevance. The expected impact on the fellow includes the acquisition of advanced research skills, enhanced interdisciplinary collaboration experience, improved transferable skills, and the development of a strong understanding of industry-driven research, preparing the fellow for a leading role in the field of sustainable energy technologies. SUS-BATT's impact is multifaceted, contributing to scientific knowledge, economic growth, and societal benefits by advancing sustainable energy storage solutions. The project aims to reduce the cost and environmental impact of battery production, supporting the transition to cleaner energy technologies.

Keywords: phosphine ligands metal organic frameworks sodium ion batteries porous carbon materials mxenes
Structures in Ionized Models of Dusty Protoplanetary Disks (SimplyDisks)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Understanding how planets form in disks around young stars is a fundamental part of astrophysical research. With the advent of the Atacama Large (Sub-)Millimeter Array (ALMA) and other large-scale telescopes and interferometers, the field of planet formation has been transformed by the stunningly complex structures observed in disks around young stars in the solar neighborhood. But at the same time, theoretical models have struggled to explain these observations, in part because many physical processes are investigated individually. Therefore, a more comprehensive model of protoplanetary disks is needed. With the SimplyDisks project, I will perform the first global 3D Magneto-Hydrodynamic simulations that treat the interaction of dust, gas and magnetic fields within protoplanetary disks self-consistently. The simulations will focus on the outer regions of the protoplanetary disk, where ambipolar diffusion suppresses the development of the MRI, and where the Vertical Shear Instability is active in the midplane regions. The self-consistent treatment will be achieved through the development of an extended ambipolar diffusion module. With these models, I will be able to (1) analyze magnetic and pure hydrodynamic processes occurring in protoplanetary disks in context and unveil if they are the driving forces behind the observed structures, and (2) find locations of dust concentration that survive long enough to trigger the formation of planets. Together with observations, the results from these self-consistent models will help us understand where and how planets form, and thus why our solar system looks different from many systems observed around other stars.

Keywords: protoplanetary disks,magnetic fields
Raising the bio-based industrial feedstock capacity of Marginal Lands (MarginUp)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Germany,Sweden,Greece,Hungary,South Africa,Argentina,Spain,Cyprus,Denmark,Belgium
Call: Marginal lands and climate-resilient and biodiversity-friendly crops for sustainable industrial feedstocks and related value chains (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 7829821.28
EU funding (EUR): 6992754.31
Participants: 30
Project status: SIGNED

At the present, 60-70% of all soils in Europe are in unhealthy conditions, mainly because of poor land management practices, pollution of soils, intensive agriculture, and the constant effects of climate change. This situation is further aggravated given that 25% of land is at a high or very high risk of suffering desertification in most parts of Europe. MarginUp! proposes a strategy to secure use and return profitability on marginal lands. Its main objective is to introduce climate-resilient and biodiversity-friendly non-food crops for sustainable industrial feedstock in marginalised and low-productivity lands. The project will focus on producing biomass to be used as raw material for the production of bioproducts and biofuels, which in turn, will create a sustainable and circular value chain, increasing the farming system resilience in rural areas. To further enhance the biodiversity beneficial impact, MarginUp! is focusing on understanding which marginal lands are suitable for low ILUC biomass production. The knowledge gathered in this project will be put into practice in 5 different use cases located in 5 different regions across Europe: - Mediterranean Lands (Spain) - Mine Lands (Greece) - Boreal Lands (Sweden) - Wetlands (Germany) - Central Europe (Hungary) Moreover, international cooperation has been considered and examination and identification of marginal lands will extend to non-European countries such as Argentina and South Africa. To ensure the success of the project, MarginUp! will have a replication network to address the needs and requirements of relevant stakeholders, including, policymakers, land managers, farmers, the bio-based industry, environmental authorities, the academia and the civil society. MarginUp! is directly contributing to European policies such as the European Green Deal, the Circular Economy action plan and the Bioeconomy and Biodiversity strategies.

Keywords: biomass production,circularity,bioproducts,marginal lands restoration,biodiversity,low iluc,value chain,farmers,industry,
Unintentional discrimination detected and racism reveal and Deactivate (UNDETERRED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: France,Romania,Netherlands,Canada,Spain
Call: Strengthening racial, ethnic and religious equality (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 3049101.24
EU funding (EUR): 3049101.24
Participants: 13
Project status: SIGNED

The main objective of UNDETERRED is to strengthen the fight against racial, ethnic and religious inequalities experienced by the younger generation (18-35 years old) of immigrant and national minority populations in Europe. In this perspective, action research will take the systemic dimension of discrimination as a priority. It will focus on improving knowledge about the norms, procedures and practices that produce racial, ethnic and religious inequalities in the EU without 'institutional intentions' in the housing, employment, health and higher education sectors.

Keywords: racism,discriminations,systemic,inequalities,unintentional mechanisms
Predicting, reducing, and offsetting CO2 Emissions through an automatic real time technology to accelerate in the road to Zero Emissions for the Entertainment Industry. (Creast)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Producers Guild of America, the main US authority governing Entertainment Industry, highlighted that this industry generates more CO2 emissions than aerospace, clothing, hotels or semiconductors sectors. A recent French study that deals with decarbonizing entertainment without being affected explains that digital data consumption accounts for between 3-4% of global Green House Gas (GHG) emissions and that entertainment alone accounts for more than 70% of that consumption. Additionally describes that this industry is the third most important cause of mobility in the world, requires large infrastructures that demand enormous amounts of energy, where consumption of food is a significant source of emissions, and many materials are used, all of which generates huge amounts of waste. This industry has reduced timings, budgets, multiple simultaneous tasks, and difficulties integrating sustainability into its processes without impact on its goals. The staff involved lack the necessary knowledge of sustainability and are reluctant to take on new tasks. However, the entertainment industry must meet this challenge as increasingly demanding regulations require it as a priority, due the ‘European Green Deal’ goals. Current solutions such as costly traditional consultancies or basic CO2 calculators that require a lot of dedication fail to reduce CO2 footprints. Creast meets this challenge by developing a digital, automated solution that helps companies achieve their sustainability goals effortless, while preserving creativity, efficiency, and compliance.

Keywords: environmental sustainability,climate change,global warming,technology,entertainment big data,artificial intelligence,digital