Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next-Generation Drug Discovery Platform for Targeting Cancer Stem Cell Pathways (ACHILLEUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 2433125.0
EU funding (EUR): 2433125.0
Participants: 2
Project status: SIGNED

Colorectal cancer (CRC) is one of the most frequent cancers with a high burden on society. In Europe alone, more than 340,000 people are diagnosed with colorectal cancer each year. While treatment options of CRC have expanded over the last decades, the survival rates of patients suffering from advanced-stage cancers remain poor. Stemness of neoplastic cells has been proposed as a major factor in treatment resistance and high relapse rates, however, drugs targeting stem cell signaling pathways in cancer are still lacking today. We propose developing and validating a new drug discovery platform based on patient-derived organoids (PDOs) and machine learning-assisted phenotypic target validation and drug discovery. Using this platform, we have previously shown that we can identify a broad spectrum of phenotypes beyond lethality, including drug-induced changes in stemness of PDOs. As part of the EIC Open Transition project, we will validate our next-generation platform for identifying therapeutics to target stem cell signaling pathways in CRC. Based on results by us showing that an interaction of MEK and Wnt signaling shifts the balance between stemness and differentiated cells, we will target Wnt pathways as a demonstrator for the technology. The ACHILLEUS project targets critical vulnerabilities in cancer and is based on technologies and approaches developed during previous ERC Advanced and ERC Proof-of-Concept grant-funded projects. The project?s ultimate aim is to spin out a NewCo as a phenotypic drug discovery platform for targeting cancer stem cell pathways.

Keywords: drug discovery,phenotypic drug discovery,machine learning and computer vision,stem cell signaling,wnt signaling,high throughput biology
DEVELOP-MENTALITIES – Islamic and Islamist Views of State, Society, and Economics in Yemen (DEVELOP-MENTALITIES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-15
End date: 2026-12-14
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

How applicable are economic development models, approaches, and policies of the EU to the ideational, political, and structural conditions of Middle Eastern societies? This project provides answers to this question by examining Islamic and Islamist views on state, society, and economics in Yemen – the poorest country in the MENA region. The project contrasts divergent ideas of development among Yemen’s Islamists-in-exile, focusing on the Houthis, the Salafis, and members of al-Islah living in Turkey, Saudi Arabia, the United Arab Emirates 8UA), and Oman, comparing local "develop-mentalities" with those prevailing among Western donors. It leverages the momentum of the slowdown of hostilities enabled by the recent Iran-Saudi deal, and the ongoing Saudi-Houthi negotiations, through an innovative methodology that combines concepts and approaches from Oral History, ethnography, economics, and politics. Academically, the project breaks new ground in the field of Islamic and Islamist economics by enriching our understanding of how political actors in the Global South think about state, modernity, globalization, and capitalism. It thereby contributes to Yemen’s history since 2011 while enriching our understanding of MENA geopolitics with new subaltern perspectives of the southern Arabian Peninsula. It further sheds light on the intersectionality between the epistemic universes of Western development theory and practice, and its applicability and receptivity in a complex, war-torn society that is dominated by tribalism and power politics. The secondary objective is to make a tangible contribution to the EU’s current efforts to transition beyond humanitarian, and towards economic, forms of development policy. By creating an unofficial line of communication between Yemen's Islamists and EEAS officials, the project intends to yield pragmatic and actionable policy outcomes while adding a critical, but constructive, perspective on the EU’s current development efforts in Yemen.

Keywords: yemen,economic development,political islam islamism,history of yemen
Healthy Public eNgagemeNt IN Groningen - Chronically Healthy (HPNNING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 290231.0
EU funding (EUR): 290231.0
Participants: 2
Project status: CLOSED

Healthy Public eNgagemeNt IN Groningen - Chronically Healthy promotes science and scientists on public health in an interactive, accessible and innovative way. Our main goal is to inform the residents of the northern Netherlands on the impact of Sleep and Toxics on public health and about researchers and their work. Education program We teach children about the effect of Sleep and Toxics on our health and ways to avoid being harmed by toxic elements in water, food, soil or air or by lack of sleep. By bringing researchers into the classroom and having children actively perform science, we increase their understanding of science and encourage the pupils to embark on research careers. Besides that we train teachers to bring science into their classrooms, which promotes a durable effect. European Researchers’ Nights During the Nights a bridge is built between researchers and the audience in an entertaining and educational quiz show. The show invites multidisciplinary researchers to share their research findings on Sleep (2022) and Toxics (2023) and invites members of the public to share their experience. Both years two different shows are created; one for children and one for adults. Both years an interactive exhibit will be developed. Engaging with this exhibit, the visitor gains insight in the importance of Sleep and Toxics and the role of science in everyday life. Moreover, the visitor experiences how she can - directly or indirectly - take more control of her own health and the people around her. Alongside the exhibit, researchers will hold informal, accessible and interactive talks on their own subject of research. Post-events After the Night, the exhibit will tour to schools and community centres in the region to reach out to the public that does not usually interact with science. In excursions to the visualisation experts of the University of Groningen and the Dutch authority on food and consumer product, school classes get to see science in action.

Keywords: public health,public engagement,science education,sleep,climate change,toxic,pollution,soil,air,nanoplastics,health policy,environment
Mythical Discourse and Religious Agency in the Puranic Ecumene (PURANA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2499331.0
EU funding (EUR): 2499331.0
Participants: 1
Project status: SIGNED

The Puranas (Primordial Texts) constitute the most voluminous and enduring genre of Sanskrit literature. These anonymous texts narrate the mythic cycles associated with the major deities of Hinduism (Visnu, Siva, Brahma, the Goddess, etc.). The Puranas have also been integral to processes of ‘place-making’ by creating maps of geography and celebrating the salvific potential of sacred sites in myths that imbue the landscape with divine agency. While many important Puranas were first recorded and circulated in the first millennium CE—a time of significant social change marked by the flourishing of regional devotional movements and innovations of temple and image-centered religious practices— the genre has remained a living tradition through the colonial period until the present day. Despite the tradition’s centrality for cultural production in South Asia, we know very little about their historical embeddedness, as the Puranic composers and transmitters—in accordance with the anonymity characteristic of the genre—disguised their own historicity behind claims of ‘primordiality’ and divinely inspired teachings. More than just a body of literature, the Puranas are a dynamic mythical discourse. PURANA makes a critical intervention in the field by tracing the composition, transmission, translation, and agency of the Puranas as a transregional and transhistorical process involving multiple actors, audiences, and geographic contexts—from Hindu scribes and Persian poets to Portuguese Jesuits and Khmer rulers. Adopting a longue durée perspective, we argue that the Puranas’ mythical discourse underlies and unites the religio-political culture of the Sanskrit Cosmopolis—establishing what we call a ‘Puranic Ecumene’: a vast part of the inhabited premodern world united by a distinctive mythical discourse, a hegemonic vision of the integration of society and cosmos, and a remarkable way of anchoring the present in the continuing ancient past.

Keywords: sanskrit hinduism south and southeast asia mythology
INfrared FibeR Analysis of battery electroLYTe dynamIC chemiStry (INFRALYTICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

As global energy demands escalate, and the use of non-renewable resources becomes untenable, renewable resources and electric vehicles require far better batteries to stabilize the new energy landscape. To maximize battery performance and lifetime, understanding and monitoring the fundamental mechanisms that govern their operation throughout their lifetime is crucial. Unfortunately, from the moment batteries are sealed until the end of their life, they remain a "black box", and our understanding of the health status of commercial batteries is limited to measurements of current, voltage, temperature, and impedance, at the cell or even module level during use. However, the landscape has recently evolved with the integration of optical fiber-based sensors into batteries, providing unprecedented insights into their thermal and mechanical properties. A significant breakthrough in this trajectory is the successful integration of Infrared Fiber Evanescent Wave Spectroscopy (IR-FEWS) into commercial Na-ion cells. This achievement enables real-time monitoring of battery chemistry dynamics during operation, marking a paradigm shift in battery design with the potential for enhanced performance, extended lifespan, and enhanced reliability. INFRALYTICS aims to explore the myriad of opportunities opened by this advance. The initiative kicks off by integrating chemical monitoring using IR-FEWS into battery cells, delving into the evolution of electrolytes and the formation of parasitic products—be they soluble, solid, or gaseous. Through a synergistic approach involving optical fiber design, electrochemical data generation, and data-driven modeling, the project strives to develop a technology capable of bridging complex degradation phenomena with batteries' long-term performance. By addressing current knowledge gaps, INFRALYTICS aims to position the EU research and industry to produce more efficient and durable batteries, thereby contributing to a more sustainable future.

Keywords: battery,characterizations,electrolytes,interfaces,infrared spectroscopy
Offshore Freshened Groundwater Prospecting using Machine Learning (OPTIMAL)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Malta,Netherlands
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 161411.52
EU funding (EUR): 161411.52
Participants: 3
Project status: SIGNED

Offshore freshened groundwater (OFG) refers to fluids stored in sediment pores and rock fractures below the seafloor, with a salinity lower than seawater. This phenomenon has been identified globally in continental margins and proposed as a resource that can potentially alleviate water stress in coastal regions. However, the scarcity of data to constrain the distribution and volumes of the reservoirs remains a challenge. OPTIMAL project aims to: (i) develop an interdisciplinary methodology to predict the occurrence and distribution of OFG resources built on Artificial Intelligence and (ii) apply the model globally to infer OFG occurrence and quantify the resource feasibility as a function of distribution characteristics such as offshore extent, depth below the seafloor and fresh to brackish water ratio. The proposed methodology uses a surrogate model to create a dataset of input parameters, representing key geological and geomorphological components influencing OFG systems, such as aquitard thickness and seafloor bathymetry. The output data will be generated via numerical simulation of variable-density groundwater transport on the suite of surrogate models using high-performance computing. These data will be used to train and test machine learning algorithms. The successful models will be validated using real-world data from the existing global OFG database. The predictive model proposed in this fellowship contributes to achieving Sustainable Development Goals related to technologies for improving access to water resources. The primary beneficiary of this funding will be the University of Malta. Partner organizations will be Utrecht University and Deltares in The Netherlands. The action presents a unique opportunity for the fellow to transfer his expertise in stochastic reservoir modelling and characterization of OFG systems to the host, while learning about marine geology, seafloor landforms and applied machine learning.

Keywords: offshore freshened groundwater,high performance computing,machine learning,geology,geomorphology
Extremely High-Speed Laser Processes For Sustainable And Flexible Manufacturing (LaserWay)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Spain,Germany,Czechia,Italy,Netherlands,France
Call: High-precision OR complex product manufacturing – potentially including the use of photonics (Made in Europe and Photonics Partnerships) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6535227.64
EU funding (EUR): 5392275.72
Participants: 16
Project status: SIGNED

Recent events such as the COVID pandemic and the Ukraine war have increased global uncertainty and prompted European companies to rethink their global supply chain and production methods. Given the unpredictable nature of potential shocks, it is crucial for European industry to maintain a high degree of flexibility and adaptability in order to swiftly respond to sudden changes, whenever they may occur. The LaserWay project aims to revolutionize the manufacturing industry by replacing conventional, inefficient, and environmentally harmful methods with highly flexible production lines based on high-speed laser technology. Laser blanking, laser micro-drilling, and extreme high-speed laser material deposition (EHLA) are the three laser manufacturing technologies selected for their potential to create more sustainable manufacturing processes and products. The project focuses on developing WayFASTER machines to improve the performance of the laser technologies through lightweight designs, vibration control techniques, and program optimizations tailored for high-speed laser applications. WayFASTER Photonics aims to ensure precise delivery of the laser beam at extreme speeds, targeting three laser technologies with unique demands. The WaySTRONGER integration concept aims to enhance the sustainability, resilience, and flexibility of current manufacturing processes by integrating new technologies mechanically and digitally. The project's success will provide a competitive edge for industries, such as automotive and aerospace, by reducing processing times, improving material usage, and enhancing end-product quality. The advancements made through the LaserWay project will drive innovation in high-speed laser processing, solidifying Europe's position as a global leader in advanced manufacturing technologies.

Keywords: extremely high speed,laser,dynamics,photonics
Political polarization: causes, consequences, and solutions (POLARIZE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1862500.0
EU funding (EUR): 1862500.0
Participants: 1
Project status: SIGNED

Political polarization has risen in many countries over the past decades and cross-party animosity now extends to previously non-partisan issues. Polarization is alarming as it undermines social cohesion, fuels distrust in institutions and violence against out-groups, and can even favor the emergence of conspiratorial beliefs. These cleavages also hinder intergroup cooperation, making it difficult to build the broad political support needed to tackle urgent social challenges. Many have ascribed the rise in polarization to the Internet and social media, seen as disproportionately exposing individuals to like-minded content and people, thus further reinforcing their opinions. Yet, the causes of political polarization, and the role of the Internet, remain largely understudied, and few solutions have been proposed to reduce polarization and avert its direst consequences. My project investigates the technological and social determinants of political polarization and its broader consequences for society, and explores possible ways to alleviate this problem. To this end, I tackle four distinct but intertwined questions. First, I examine the extent to which personalized search engine results expose users to divergent political content and affect their political views. Second, I study the extent to which the introduction of paywalls by online news outlets has affected users’ news consumption, information inequities, and ideological segregation. Third, I examine how technology-driven economic shocks that favor social exclusion and undermine workers’ identity influence beliefs in conspiracy theories. Finally, I study whether perspective-taking interventions can offer an effective tool for reducing ideological and ethnic tensions, and promoting intergroup cooperation. My results will provide a unified framework for understanding the complex technological and social forces behind political polarization, and for formulating concrete policy recommendations on how to mitigate it.

Keywords: political polarization algorithmic bias search engines paywalls conspiratorial beliefs political effects of robotization and automation perspective taking
New European Bauhaus STAvangeR (NEB-STAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Coordination and support actions
Countries involved: Norway,Czechia,Netherlands
Call: Support the deployment of lighthouse demonstrators for the New European Bauhaus initiative in the context of Horizon Europe missions (HORIZON-MISS-2021-NEB-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4999721.25
EU funding (EUR): 4999721.0
Participants: 17
Project status: SIGNED

In NEB-STAR, 16 partners will join forces to make the transition to climate-neutral cities inclusive, beautiful and sustainable - for, by and with all stakeholders. Stavanger as the first-generation NEB Lighthouse will provide experimentation, demonstration, insight and guidance on NEB principles in urban transitions in cooperation with twinning cities Prague and Utrecht, and peers in Europe and the Nordics. The project will demonstrate how Territorial Transformation Plans can be operationalised with NEB principles to accelerate the journey towards climate neutrality. In NEB-STAR, NEB principles will be used to address four emblematic challenges: (1) co-creating a new sense of aesthetics for climate-neutral cities and communities that captures places' unique qualities, history and potential, and generates a sense of belonging, pride and ownership; (2) Reconnecting with nature to boost resilience and a sense of community, giving new life to the spaces in between buildings through food and nature; (3) Creating temporary meeting spaces in urban transition areas, that embrace diversity and strengthen the identity and uniqueness of people and places that need it most; (4) Co-creating co-benefits for the neighbourhood and city through multi-functional use of spaces and infrastructures. The project will deliver a Detailed Roadmap for full-scale implementation of Stavanger’s Territorial Transformation Plan, supported by an extensive Co-Creation Process, a Portfolio of Policy Strategies and Tools, Financial and Partnership Models. The plans will be co-created with local stakeholders and partners, tested in Demonstrators in the three cities, jointly evaluated with stakeholders and experts, and exploited and replicated in cooperation with Nordic and European NEB and Missions communities. The NEB-STAR Impact Model will capture the social, cultural, financial, governance and technical impact on the built environment, and the stakeholders that affect / are affected by them.

Keywords: territorial transformation plan,re skilling society,new european bauhaus,co creation process,progress stories,aesthetics of climate neutral cities,nature and food based solutions