Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EPiTB: Addressing an unmet need: same day diagnosis of extra-pulmonary TB in a high burden setting. (EPiTB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: South Africa,Netherlands,Zimbabwe,Zambia
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 3989909.25
EU funding (EUR): 3989909.25
Participants: 4
Project status: SIGNED

Better diagnostic approaches are required to improve TB control in Africa, which is suboptimal. One neglected aspect of TB diagnosis is that of extrapulmonary TB (EPTB), which comprises ~15% of the TB caseload. However, in HIV-endemic settings over one third of cases are due to EPTB (the most common manifestation being pleural TB). Frontline same day sputum-based diagnostic tools such as GeneXpert perform poorly when using fluid derived from EPTB-specific compartments (e.g. pleural fluid). Indeed, GeneXpert sensitivity in pleural TB is ~35%. ADA, the current standard of care used in clinical practice has poor specificity, especially in pericardial TB and TB-meningitis (see preliminary data). By contrast, unstimulated interferon-gamma (not T-cell-based IGRAs that require overnight stimulation) is an excellent biomarker for the diagnosis of EPTB (confirmed in 2 meta-analyses). A South African university start-up has now developed a low-cost same-day EPTB diagnostic test (IRISA-TB), which has been evaluated and published in several small clinical trials (see main proposal) and is locked-in for scale-up dissemination in 2022. The test is CE marked, SAHPRA approved, and endorsed by the Global Fund. This proposal encompasses a large prospective multicentric study (n= 2170 patients) of IRISA-TB in various forms of EPTB (pleural, pericardial, and peritoneal TB, and TB meningitis). The proposed study (EPiTB) has excellent fidelity with the EDCTP call because it will enable “the registration of a new health technology through pragmatic effectiveness studies”, “enable uptake of results into clinical practice” and facilitate WHO endorsement. Thus, EPiTB will drive the facilitation and uptake of an important new TB diagnostic test in Africa. Importantly, an African-invented and designed test will be promoted. Indeed, innovation and the development of an African knowledge-based economy is a key priority of the EDCTP.

Keywords: tuberculosis,diagnostics,implementation research,interferon gamma,extra pulmonary tb
European Citizen Science (ECS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Germany,Italy,Israel,Greece,Croatia,Czechia,Denmark,Portugal,Ireland,Netherlands,France,Norway,Belgium,Spain,Austria
Call: A capacity-building and brokering network to make citizen science an integral part of the European Research Area (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-08-01
End date: 2026-07-31
Duration (months): 48.0
Total project cost (EUR): 3999043.75
EU funding (EUR): 3999043.0
Participants: 21
Project status: SIGNED

The overall objective of ECS is to widen and strengthen the European Citizen Science community through capacity building and awareness raising activities such as the creation of a European Citizen Science Academy and the establishment of a network of 28 ECS Ambassadors. ECS will capitalise on EU-funded actions such as the EU-Citizen.Science platform and Cos4Cloud to support links and collaboration between members of the European Citizen Science community, who will be involved in the co-design and co-creation of a large variety of services, strategic priorities, training opportunities and policy recommendations. A key focus is on inclusivity, which will be achieved through dedicated actions such as engaging libraries affiliated to the Public Libraries 2030 network to attract underrepresented publics, as well as ad-hoc support to countries/regions lacking citizen science networks, platforms and policy recognition. ECS will create extensive capacity building opportunities by engaging in particular excellent researchers in a variety of disciplines, for example through the involvement of the Marie Curie Alumni Association, and emerging Horizon Europe Missions, Clusters, and wider ERA activities, to allow easy access for newcomers in citizen science activities. ECS is committed to push modern science towards open science as its modus operandi by providing open collaborative spaces where citizen scientists can familiarise with the concept of "open and FAIR data with open and FAIR tools" and get actively engaged, while connecting with existing e-infrastructures such as EOSC through the collaborative development of data/metadata services. The engagement of the Global Citizen Science Partnership will guarantee wide international cooperation. These efforts will result in a number of key scientific, societal and policy impacts which will strongly contribute to securing Europe's global position as a leader in citizen science throughout the entire research and innovation system.

Keywords: citizen science,open science
The Everyday Politics of Famine (PolFam)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1481283.75
EU funding (EUR): 1481283.75
Participants: 1
Project status: SIGNED

Famines are becoming more frequent and deadly, with 250,000 people experiencing famine in 2022 and 35 million people being on the edge of famine. For decades there has been a scholarly consensus that famine is the result of political failure or design, and never solely the result of natural disasters. However, a political culture that makes famine politically unconscionable and that ends famine has not emerged. To understand why famines persist we need to deepen our understanding of famine politics; so far scholarship on the politics of famine has focus on national and international institutions, and the instrumental use of famine by actors and institutions. My research will produce a ground-breaking shift in the science of famine politics by focusing on the everyday politics of famine in communities where it occurs. I am interested in how discourses and the ‘regime of truth’ about famine disperse throughout the social body (in Foucault’s words). In particular, I am interested in how new deadly famines come to be normalised, preventing political rupture. Plus, I am interested in how these discourses can shift blame for famine suffering away from governments, warring parties and actors in global economies, and instead place blame on natural causes and the families of those who suffer and die. To achieve this, I will conduct an ethnographically-informed comparative study across four sites in South Sudan and in Somalia. Initial ethnographic insights have made me structure the research around four cross-case-study research strands: histories and musical memories of past famine; community-narratives that enforce social networks; burial and posthumous practices; and media and social media’s role in anti-famine politics. This ambitious project is feasible because of my previous experience and networks, and because I have carefully built the capacity and track record of a team Somali and South Sudanese – dominated research team.

Keywords: famine everyday
Discovering Mineral nAnoinclusions in DiAaMonds (MADAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 3499978.0
EU funding (EUR): 3499978.0
Participants: 1
Project status: SIGNED

Diamonds are the only geological materials able to travel hundreds of kilometres vertically, horizontally and through time for billions of years, being un-modified since the day of their formation. Not just a time capsule, when diamonds incorporate mineral inclusions captured from the deep mantle, they represent an open window into otherwise inaccessible regions of Earth. Based on their formation depths, diamonds are classified as lithospheric (formed between about 120 and 200 km depth) and sublithospheric (formed much deeper, between 300 up to 1000 km depth). However, a third class of diamonds - “fibrous diamonds” - is much less studied and the origin of such enigmatic diamonds is still contentious. While lithospheric and sublithospheric diamonds can capture mineral inclusions providing crucial information about the deep Earth, fibrous diamonds are typically characterized by the presence of billions of submicrometric fluid inclusions. Such inclusions provide information about the composition of the diamond-forming fluid, but the scarcity of mineral inclusions means that their formation depths and rock substrates are poorly constrained. Based on the PI’s recent pilot study, the MADAM project will, for the first time, investigate the structure and nature of nanometric mineral inclusions in fibrous diamonds, providing unprecedented information about these enigmatic diamonds. If funded, the MADAM project will enable the PI to acquire the first electron diffractometer applied to geoscience worldwide. This quantum leap in technology now allows the determination of the structure of any crystalline material at nanometric scale in less than 2 minutes. Application to fibrous diamonds this technique will allow the study of a large number of samples (> 100 diamonds per year) from a global distribution of sources, providing a definitive resolution of their depth of formation and geological significance.

Keywords: diamonds,nanominerals,electron diffraction,earth s mantle
Potentiality and Essence: An Integrated Actualist Theory of Metaphysical Modality (POTandESS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

This project investigates the source of metaphysical modality, that is to say, it is concerned with the question: “In virtue of what are some facts necessary and others possible, contingent, or impossible?”. In particular, it will focus on the systematic investigation of the relations between the two main “new actualist” theories of modality, which share the idea that modal facts can be explained by, or grounded by, more fundamental, wholly actual phenomena. The former aims to ground modal facts in the irreducibly dispositional properties possessed by actual objects—powers, capacities, potentialities, and so on. In its simplest terms, it states that something is possible if and only if there is a (chain of) actual power(s) directed at it, and necessary if and only if there is no power to bring about the truthmaker of its negation. The latter aims to ground modal facts upon the essences of actual objects: what must be the case follows from the nature or identity of the existing entities, and what can be the case is whatever does not clash with said natures. In its simplest terms, it states that something is necessary if it is part of the essence of everything, and possible if its negation is not contained in the essence of everything. In recent years, each of these two theories has generated a rich and influential literature and have proved to be among the most serious candidates as sources of modality. However, their weaknesses have also started to become clear: Dispositionalism seems to have a hard time accounting for logical and mathematical necessities, while essentialism seems to struggle more in accounting for the kind of modal truths involved in the causal, dynamic, diachronic evolution of a system. The aim of the current project is to develop an integrated theory, which incorporates elements of both theories and avoids their weaknesses

Keywords: metaphysics modality necessity essence potentiality dispositionalism fine vetter
Rise of the Structure-encoded UNC5 interactome in aggressive behaviours of Neuro-developmental tumours (SUNRISE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,United Kingdom,Spain
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-03-01
End date: 2031-02-28
Duration (months): 72.0
Total project cost (EUR): 8050793.0
EU funding (EUR): 8050793.0
Participants: 3
Project status: SIGNED

Paediatric tumours represent a challenge in the landscape of cancer research. Unlike adult cancers, they typically originate from embryonic cells, from which they inherit characteristic embryonic features. This is exemplified by neuroblastoma (NB), the most common solid tumour in young children. NB is a heterogeneous cancer with aggressive metastatic forms, which emerges from neural crest cells. These cells normally undergo a complex migratory process that depends on the functions of cell surface signalling receptors. In a recent, ground-breaking study we found that NB cells co-opt one specific family of these receptors (UNC5) and the ligand GPC3 to disseminate (Cell 2022). Disruption of this interaction in vivo impacted on cell cohesion, migratory properties and redirected tumour localisation. Here we provide unpublished data analysis, suggesting that an entire UNC5 interaction network, involving multiple different ligands besides GPC3, is at play in malignant NB. Understanding the mechanisms driving NB cell aggressive behaviours requires investigation of this network in the embryonic context. A key strength of the proposal is our unique approach bringing molecular/structural biology to in vivo experiments. Our strategy maximises the use of targeted, structure-based perturbation experiments, where we control the activity of individual receptor interaction precisely, in vivo. We also have the necessary access to patient samples and will use our innovative avian xenograft model which recapitulates the embryonic environment of NB. In a final workpackage we will apply our strategy, developed with a focus on NB, to two other paediatric cancers where UNC5 is expressed. In sum, the results of SUNRISE will produce a first detailed picture of the ‘where’, ‘when’ and ‘how’ UNC5 network interactions drive paediatric cancer biology, and could lead to new therapeutics, for example, using nanobody technology.

Keywords: membrane receptor,cell migration,cell cell interactions,neuro developmental cancer,neuroblastoma,structural biology,embryonic neuro development
Harnessing by-products for the creation of eco-friendly and sustainable diesel fuel (VERDEDRIVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece,Bulgaria,Serbia,Belgium,Türkiye,Cyprus
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1901114.29
EU funding (EUR): 1633000.0
Participants: 10
Project status: SIGNED

As global energy consumption continues to rise, resulting in higher energy demand, the inadequate supply of fossil fuels becomes apparent. Conventional diesel fuel, which is produced by distilling crude oil, is essential for driving automobiles. Renewable energy sources could be a viable substitute for conventional diesel that comes from fossil fuels. Triglycerides and alcohol can be converted into biodiesel, a sustainable liquid fuel, using a straightforward procedure called transesterification. After conducting research, the International Energy Agency (IEA) concluded that approximately 80% of the world's total primary energy comes from fossil fuels, with oil accounting for 32.8%, followed by coal at 27.2%, and natural gas ranking third at 20.9%. VERDEDRIVE [Harnessing by-products for the creation of eco-friendly and sustainable diesel fuel] rationale lies in suggesting investigating and examination of the possibility of utilizing by-products for the production of renewable and green diesel. Specifically, the project aims to conduct a comparative study of oils derived from alternative natural crops and raw materials—Roses petals, Sour Cherries (Variety Oblaćinska višnja), Maize, Local Soybean Variates and Cynara cardunculus—with the objective of identifying the most suitable raw material for the production of green diesel. VERDEDRIVE encompasses a comprehensive approach to biofuel production from by-products, integrating precision agriculture and surveillance technologies in the collection and processing stages, in conjunction with state-of-the-art methodologies from the fields of Chemical Engineering, Environmental Science, Agriculture, Biotechnology, Modelling, Computer Engineering and Environment Engineering, aims to demonstrate a scientifically-sound approach to biofuel production. VERDEDRIVE activities are strategically positioned to drive innovation in response to demand in the biofuels sector.
Synergistic Control Technology: Muscle Activation-Based Intention Estimation and Vision-aid Assistance in Upper Limb Prosthetics (SynConT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Prosthetic devices and their assistive technologies (ATs) have been socially demanded by several factors, including higher rates of traumatic amputations from accidents and an aging population. Regarding upper limb prosthetics, the amputation statistics show that the major cause is traumatic incidents, such as workplace or road accidents, particularly affecting the working-age population. The demand also has accelerated while human life expectancy increases, and society enters an aging demographic. By 2070, the share of the population aged 65 and over is expected to grow from 20% in 2019 to nearly 30%. The Global incidence of traumatic amputations has increased including upper-limb amputation around 16.4%. To this demand, the European orthopedic prosthetics market is projected to grow (Compound annual growth rate (CAGR): 5.4%) from 2024 to 2030 and over 75000 prosthetists are required globally to support individuals with traumatic amputations1. Advancements in upper-limb prosthetics improve healthcare, rehabilitation, daily life, and workforce participation for amputees, benefiting society and boosting economic growth. In this proposal, A Synergetic SPC (SSPC) based novel framework is proposed and it will offer highly accurate, robust, and object interactive advantages. SSPC will overcome LMs by 1) Design a signal processing algorithm for the acquisition of muscle unit activation and Machine learning (ML)-based intention estimation model by spatial and temporal signal consideration, 2) Vision-aid real-time grasping assistance algorithm, and 3) Design SSPC framework. (a) Offline simulation analysis and (b) Real-time clinical trials will be conducted as solid support of “Synergistic Control Technology: Muscle Activation-Based Intention Estimation and Vision-aid Assistance in Upper Limb Prosthetics (SynConT)”. It will contribute to prosthetics technology beyond the state of the art and bring it to daily life.

Keywords: prosthetics,assistance grasping,intention estimation,signal processing,biomedical engineering,neurorehabilitation technology
Green materials for neurOMorphic signal processing by organic synaptic transistors (GreenOMorph)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Austria,Italy,Finland,Netherlands,France,Slovenia
Call: EIC Pathfinder Challenge: Responsible Electronics (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2029-03-31
Duration (months): 54.0
Total project cost (EUR): 4419796.75
EU funding (EUR): 4419796.75
Participants: 7
Project status: SIGNED

Electronics today cause major environmental impacts through manufacture, use and disposal, as well as growing concerns about Europe's economic and technological dependence on other regions of the world. The overall objective of GreenOMorph is the radical reduction of the environmental impact of electronics manufacture, use and end-of-life as well as a total avoidance of critical raw materials in manufactured devices. We attack this goal on the one hand by choosing neuromorphic instead of common Von Neumann computing reducing the energy consumed during use by several orders of magnitude. On the other hand, we completely rely on organic electronics with innovative green materials and additive low-temperature manufacturing by blade coating, screen-printing and inkjet printing, in all parts of an organic artificial sensory neuron for recognition of tactile pressure patterns. The parts of the neuron, as there are an organic tactile sensor, organic signal conditioning circuits and organic artificial synapses, as well as the neuron itself are validated outcomes of the project and contribute to the project portfolio of Responsible Electronics already during their development. The outcomes of the project will help to replace a performance-at-any-cost attitude, yet staying fully aware that developing non-performing devices not accepted by users would have a great environmental impact as well; so performance targets and market analysis are equally important as the low environmental impact targets and social life cycle assessment are. Showing that it is possible to fulfil a given purpose at an environmental footprint orders of magnitude smaller than today, and at the same time reduce dependence on other regions of the world, our low-environmental-footprint-first approach will serve as a reference in the future, from scientific communities to technology developers and manufacturers through to the end users.

Keywords: sustainable,green chemistry,energy efficiency,organic electronics,transistor,tactile sensor,artificial synapse,bio mimicking afferent nerve,synaptic plasticity,ultra flexible