Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolving Security SciencE through Networked Technologies, Information policy And Law (ESSENTIAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Australia,Italy,Italy,Malta,Romania,Norway,Romania,Norway,Sweden,Belgium,Netherlands,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 3756496.68
EU funding (EUR): 3756496.68
Participants: 13
Project status: SIGNED

Though security is a field of study capable of diverse applications in daily life, security science is a young discipline requiring larger inter-disciplinary effort. ESSENTIAL seeks to develop security science by addressing two of its main problems: the ad-hoc approach to security research and the growing complexity of the security environment. To do so, ESSENTIAL has set itself two main goals: a) to train inter-disciplinary security experts and professionals, to tackle security threats in a systematic manner and b) to increase societal resilience and security by addressing in an interdisciplinary manner 15 research topics, each associated with long-standing problems in the field of security science ranging from modeling security perception and democratizing intelligence to improving security and privacy in data ecosystems. ESSENTIAL will be the first programme of its kind that aims to jointly educate the next generation of interdisciplinary experts in security science, by uniquely exposing the 15 ESRs to: (1) theoretical knowledge and practical expertise in such areas as: (a) the policing and regulation of information-security technology, and (b) the implementation of policies and legal standards within computing and communication systems; (2) real-world environments in law enforcement, intelligence and industry; (3) strong academic guidance offered by highly qualified supervisors and mentors; (4) high tech research infrastructures; and (5) a diversity of interdisciplinary research events, such as workshops, conferences, summer/winter schools. The ESSENTIAL consortium is built upon long-lasting cooperation relations among leading organizations coming from academia, international and national stakeholders and the private sector, many of whom have over 25 years of experience in contributing directly to national, European and UN technology-related policy making.

Keywords: security science,security challenges,security and privacy in data ecosystems,multi,inter disciplinary security experts and professionals,jointly educate the next generation security experts
An Integrated Computational and Experimental Approach to Rapid Synthesis of Highly Selective Dual-Targeted HDAC/CK2, MMP2/CK2 Inhibitors (DUALITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-10
End date: 2020-04-09
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Traditional drug design strategy based on a single target has serious difficulties in developing new therapies for diseases such as cancer. Cancer is a very complex multi-genetic disease that involves multiple crosstalks between signaling networks. The use of cocktails of various anticancer agents interfering with different mechanisms has been the standard treatment to prevent the problems of resistance. An alternative approach is to design multi-target modulators, directed to different disease mechanisms. That is the approach we have chosen for this project, where we seek to design, synthesize and evaluate new dual agents based on the inhibition of three enzymes involved in the development and progression of tumor processes: HDAC1, CK2 and MMP2. CK2 is a serine / threonine kinase that is constitutively active and essential for cell viability. Its proliferative and anti-apoptotic properties create a favorable cellular environment for tumor progression and maintenance and, therefore, constitutes an interesting target for the treatment of cancer. Acetylation/deacetylation of histones is one of the epigenetic mechanisms that regulates gene expression. HDACs (histone deacetylases) remove acetyl groups from histones, inducing condensation of chromatin and, therefore, the repression of gene transcription. For this reason, they are considered key targets to reverse aberrant epigenetic changes associated with cancer. Matrix metalloproteinases (MMPs), also called matrixins are another family of Zn-dependent enzymes. Our research group has extensive experience in the design and synthesis of inhibitors of MMP2 provided with high activity and, more importantly, high selectivity over other metalloproteinases. The design of multi-target modulators will be carried out making use of computational techniques and based on the previous experience of the group in the design and synthesis of inhibitors of these three targets through a fragment based process.

Keywords: hdac,enzyme inhibitors,drug design,synthesis
Interdisciplinary Synthesis of Tools for understanding Land Governance (InSiTe-LandGov)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 265957.44
EU funding (EUR): 265957.44
Participants: 2
Project status: SIGNED

InSiTe-LandGov combines big data with qualitative approaches to generate new open access datasets and methods on natural resource governance—a critical data gap in sustainability science. It will test these using existing data from a unique network of >5000 research plots across the world’s biggest savannah woodland, spanning 12 countries in southern Africa. This biome is key to European and global climate change, biodiversity and poverty alleviation goals: it supports the livelihoods of 150 million people, stores as much carbon as the Congo Basin, and is home to iconic megafauna, yet it suffers some of the highest rates of deforestation and poverty on Earth. Improved understandings of resource governance will be crucial to meeting these challenges, but empirical methods for assessing governance remain opaque, costly and spread across several disciplines. First, I will produce a typology of current methods for observing resource governance that bridges the divide between positivist and constructivist approaches. I will do this through a systematic review and workshops with experts from Europe, North America and southern Africa. Second, I will generate a new open access dataset on governance for the entire southern African woodland biome. I will use machine learning, open access ‘big’ satellite and census data, the >5000 research plots, and a field visit to Mozambique and Zimbabwe. Finally, I will produce a world-first analysis on how aspects of resource governance affect environmental degradation and poverty across the region. I will use a novel approach combining qualitative and big data methods. In this fellowship I aim to build on my existing skills to define myself as a global expert in interdisciplinary governance research, and to secure a long term job at a European university. I will draw on the expertise of supervisors at three world-class hubs of sustainability research: McGill University, University of Edinburgh and the Stockholm Resilience Centre.

Keywords: african woodlands,african savannahs,resource governance,mixed methods,big data,open data,spatial analysis,machine learning,social ecological systems,archetype analysis
Robust MINFLUX microscope for improved system stability and accessibility (RobMin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

MINFLUX super-resolution microscopy provides a 3D spatial resolution down to 2 nm combined with millisecond temporal resolution in living cells. MINFLUX has the potential of revolutionizing structural cell biology by measuring dynamic functional changes of protein machines. Currently, however, access to MINFLUX is very limited because the implementation of custom-built MINFLUX microscopes is complex, and commercial systems are very expensive. The objective of this proposal is to develop a MINFLUX system with simplified optical scanning systems, which makes the system robust, affordable, and easier to build, to provide increased accessibility to a wider range of researchers. To this end, we aim to replace the 3D scanning systems with a combination of spatial light modulators and fast switching of multiple optical fibers, without compromising its imaging speed and achievable resolution. We will demonstrate the performance of the new MINFLUX system on biological systems to showcase the system capability. The research will take place at the group of Dr. Jonas Ries at the European Molecular Biology Laboratory, a leading group in developing new approaches in single molecule localization microscopy and application in biology. This highly interdisciplinary project will strengthen my expertise in advanced optics, software programming, electronics, and biology. It will have an important impact in the field of structural cell biology by enabling direct measurements of dynamic structural and functional changes of protein machines in living cells. This fellowship will establish me as a recognized researcher in the field and will be the optimal basis to start my own research group.

Keywords: fluorescence microscopy,super resolution,single molecule localization,minflux
Flexible and robust nervous system function from reconfiguring networks (FLEXNEURO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-07-31
Duration (months): 78.0
Total project cost (EUR): 1299191.0
EU funding (EUR): 1299191.0
Participants: 1
Project status: SIGNED

It is now possible to monitor and manipulate neurons in live, awake animals, revealing how patterns of neural activity represent information and give rise to behaviour. Very recent experiments show that many circuits have physiology and connectivity that is highly variable and that changes continually, even when an animal’s behaviour and environment are stable. Existing theories of brain function assume that neural circuit parameters only change as required during learning and development. This paradigm cannot explain how consistent behaviour can emerge from circuits that continually reconfigure, nor what mechanisms might drive variability and continual change. Understanding this deep puzzle requires new theory and new ways to interpret experimental data. I will develop a theory of reconfiguring circuits by significantly generalizing my previous work that uses control theory to show how network activity can be maintained in spite of variability and continual turnover of crucial circuit components. We will analyse how biological plasticity mechanisms steer collective properties of neurons and circuits toward functional states without requiring individual parameters to be fixed, resulting in circuit models with consistent output but variable and mutable internal structures. In close collaboration with leading experimentalists we will challenge these modelling principles to account for new findings which reveal that navigation, sensory percepts and learned associations are underpinned by surprisingly dynamic, variable circuit connectivity and physiology. This will generate new, exciting questions that will drive experiments and theory together: how can known plasticity mechanisms generate reconfigurable neural representations? Do continually reconfiguring networks possess unique functional flexibility and robustness, and are they vulnerable to specific pathologies? And how can we design new experiments to test theories of robust, reconfigurable networks?

Keywords: regulatory control of neural circuits and physiology
The most profitable Solar collector on the market to supply Heat and Electricity (SHE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-03-01
End date: 2023-06-30
Duration (months): 40.0
Total project cost (EUR): 2800120.5
EU funding (EUR): 1960084.35
Participants: 1
Project status: SIGNED

Buildings are responsible of 40 % energy consumption in Europe. In spite of EU policies to reach the goal of 32% renewable energy by 2030 and to promote the standards of nearly Zero Energy Buildings, solar energy is not massively installed as expected in building sector. Potential is huge: more than 75% of building stock is inefficient and need refurbishment actions. However, solar thermal heat (for sanitary water and space heating mainly) and solar photovoltaic electricity compete for space in rooftop. Abora Solar is a company specialized in designing, developing and manufacturing hybrid solar collectors, which simultaneously provide heat and electricity. Our goal is to bring to the market the most profitable solar collector: this is SHE. We are sales’ leader in Spain with nearly 2,000 hybrid solar panels installed. However, present technology’s limitations of hybrid solar panels do not allow to reach high temperatures as solar thermal collectors and costs are too high to fulfil the willingness to pay from most of the customers: 5 years payback. We have patented a breakthrough innovation that completely changes the structure and manufacturing process of hybrid solar panels, allowing us to simultaneously increase energy efficiency and reduce costs. With SHE collector we can provide 5 year payback and supply 5 times more energy than a photovoltaic panel. We face the market of solar heat in buildings and industries, valued in € 195 billion in 2025 with nearly 450 million solar collectors installed, which additionally always requires electricity for other uses. Abora Solar ask for EIC Accelerator Pilot grant to finalise the development of our solar panel and the manufacturing line to accelerate the market launch in 2021. Our goal is to achieve 50,000 panels manufactured in Europe and sold worldwide in 2025.

Keywords: hybrid solar panel,renewable energy,cost effective,solar cooling,retrofitting,nzeb,low carbon emissions,energy in building,energy efficiency,energy transition,distributed generation
Smooth, REliable aNd Dispatchable Integration of PV in EU Grids (SERENDI-PV)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Austria,Germany,Spain,Spain,Spain,Spain,Germany,Germany,Spain,Finland,Belgium,Belgium,Slovakia,France,France,France,Portugal
Call: Increase performance and reliability of photovoltaic plants (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 12150542.2
EU funding (EUR): 9779145.879999999
Participants: 25
Project status: SIGNED

SERENDI-PV proposes innovations towards two main pillars: (1) increased lifetime, reliability, performance and profitability of PV generation; (2) utility-friendly high-penetration of the PV generation in the grids with improved stability, smart communication between stakeholders and increased knowledge of the PV fleet management. SERENDI-PV will develop advanced PV modelling, simulation and design tools, monitoring data analytics for fault diagnostic and improved O&M, as well as lab and field testing Quality Control (QC) equipment and procedures for better assessment of the reliability of PV components and systems. The innovations will be developed with particular attention to the new PV applications that are becoming increasingly relevant on the market, such as bifacial PV, floating PV and BIPV. SERENDI-PV will pave the way towards higher PV penetration through a better understanding of the PV installed capacity, smart digital models for energy and services communication exchange between system stakeholders, the development of mid-term, short-term forecasting, and nowcasting for PV system aggregations, new business models for PV added revenue, and the creation of a collaborative platform for modelling, data analytics, QC, databases and grid integration. The solutions will be developed on the data from nearly 500,000 PV installations monitored within the consortium, representing a wide range of system sizes and typologies, including large ground-mounted PV plants, mid-size commercial and industrial PV systems, and small-scale rooftop residential PV systems. The results will be achieved through an interdisciplinary approach combining the complementary expertise of the 19 different partners that take part in the consortium and that represent all the relevant stakeholders concerned by the topic of this project. The project will include several key demonstration activities in the operational environment corresponding to each one of the key innovations proposed
Cyber Physical System based Proactive Collaborative Maintenance (MANTIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Italy,Austria,Germany,Germany,Germany,Spain,Spain,Italy,Germany,Germany,Finland,Hungary,Belgium,Finland,Finland,Finland,Belgium,Finland,Slovenia,Finland,Netherlands,Netherlands,Netherlands,Denmark,Portugal,Denmark,Denmark,Portugal,United Kingdom
Call: ECSEL Key Applications and Essential Technologies (RIA) (ECSEL-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-07-31
Duration (months): 39.0
Total project cost (EUR): 29984905.83
EU funding (EUR): 9791974.05
Participants: 52
Project status: CLOSED

The overall concept of MANTIS is to provide a proactive maintenance service platform architecture based on Cyber Physical Systems that allows to estimate future performance, to predict and prevent imminent failures and to schedule proactive maintenance. Maintenance is no longer a necessary evil that costs what it costs, but an important function that creates additional value in the business process as well as new business models with a stronger service orientation. Physical systems (e.g. industrial machines, vehicles, renewable energy assets) and the environment they operate in, are monitored continuously by a broad and diverse range of intelligent sensors, resulting in massive amounts of data that characterise the usage history, operational condition, location, movement and other physical properties of those systems. These systems form part of a larger network of heterogeneous and collaborative systems (e.g. vehicle fleets or photovoltaic and windmill parks) connected via robust communication mechanisms able to operate in challenging environments. MANTIS consists of distributed processing chains that efficiently transform raw data into knowledge while minimising the need for bandwidth. Sophisticated distributed sensing and decision making functions are performed at different levels in a collaborative way, ranging from local nodes to locally optimise performance, bandwidth and maintenance; to cloud-based platforms that integrate information from diverse systems and execute distributed processing and analytics algorithms for global decision making. The research addressed in MANTIS will contribute to companies' assets availability, competitiveness, growth and sustainability. Use cases will be the testing ground for the innovative functionalities of the proactive maintenance service platform architecture and for its future exploitation in the industrial world. Results of MANTIS can be utilised directly in several industry areas and different fields of maintenanance.

Keywords: proactive maintenance,collaborative maintenance,maintenance service platform architecture
Synthetic platforms for ad libitum remodelling of yeast central metabolism (AdLibYeast)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2149717.5
EU funding (EUR): 2149717.5
Participants: 1
Project status: CLOSED

Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities. The efficiency of such engineered microbes strongly depends on their native metabolic networks. However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance. As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their function, are scattered over the genome and chromosomes. This absence of a modular organization tremendously restricts genetic accessibility and presents a major hurdle for fundamental understanding and rational engineering of central metabolism. To conquer this limitation, I introduce the concept of ‘pathway swapping’, which will enable experimenters to remodel the core machinery of microbes at will. Using the yeast Saccharomyces cerevisiae, an industrial biotechnology work horse and model eukaryotic cell, I propose to design and construct a microbial chassis in which all genes encoding enzymes in central carbon metabolism are relocated to a specialized synthetic chromosome, from which they can be easily swapped by any – homologous or heterologous – synthetic pathway. This challenging and innovative project paves the way for a modular approach to engineering of central metabolism. Beyond providing a ground-breaking enabling technology, the ultimate goal of the pathway swapping technology is to address hitherto unanswered fundamental questions. Access to a sheer endless variety of configurations of central metabolism offers unique, new possibilities to study the fundamental design of metabolic pathways, the constraints that have shaped them and unifying principles for their structure and regulation. Moreover, this technology enables fast, combinatorial optimization studies on central metabolism to optimize its performance in biotechnological purposes.