Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mixed brushes of stimuli-responsive polymers for the selective adsorption of proteins (SELECT-A-PROTEIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Advanced materials are at the heart of many scientific fields, particularly in the biomedical and biotechnological areas. Many devices (e.g., biosensors, implants, catheters, and systems for drug delivery) would benefit from an effective control over molecular and cellular interactions at material surfaces. Main challenges in this field include the control of biomolecules (e.g., proteins, DNA) adsorption on different surfaces. Designing surfaces that allow proteins to be adsorbed in a controlled manner is particularly important and challenging. Many strategies were recently developed to spatially or temporally control protein adsorption. In this project, a novel strategy for selective protein adsorption from a mixture of proteins will be developed. This strategy will be based on the use of mixed polymer brushes sensitive to ionic strength and pH of the surrounding medium. The project rests on the following steps: i. The design of mixed polymer brushes whose properties will be tuned by adjusting pH and ionic strength of the medium. The influence of polymer properties (molecular weight, and degree of dissociation and conformation through pH and ionic strength variations) on protein adsorption will be studied. ii. The development of a procedure, based on time-of-flight secondary ion mass spectrometry (ToF-SIMS), to distinguish different proteins adsorbed together on model interfaces. iii. The use of this ToF-SIMS-based procedure to investigate the potential of the created mixed brushes to selectively adsorb one protein, at first from a mixture of two or three proteins, and then from a more complex medium. The results obtained in this work will be significant for material science and biomedical applications through the development of a robust procedure to prepare “smart” surfaces with novel properties to control protein adsorption.

Keywords: polymer brush,protein adsorption,stimuli responsive polymers,polyelectrolytes,tof sims,surface characterization methods,surface modification methods
Bringing AI Planning to the European AI On-Demand Platform (AIPlan4EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Germany,Germany,Ireland,Germany,Italy,Switzerland,Sweden,Belgium,Belgium,France,France,United Kingdom
Call: Artificial Intelligence on demand platform (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 5416193.75
EU funding (EUR): 4999174.25
Participants: 19
Project status: SIGNED

Automated Planning and Scheduling is a central research area in AI that has been studied since the inception of the field and where European research has been making strong contributions over decades. Planning is a decision-making technology that consists in reasoning on a predictive model of a system being controlled and deciding how and when to act in order to achieve a desired objective. It is a relevant technology for many application areas that need quick, automated and optimal decisions, like agile manufacturing, agrifood or logistics. Although there is a wealth of techniques that are mature in terms of science and systems, several obstacles hinder their adoption, thus preventing them from making the footprint on European industry that they should make. For example, it is hard for practitioners to find the right techniques for a given planning problem, there are no shared standards to use them, and there is no easy access to expertise on how to encode domain knowledge into a planner. The AIPlan4EU project will bring AI planning as a first-class citizen in the European AI On-Demand (AI4EU) Platform by developing a uniform, user-centered framework to access the existing planning technology and by devising concrete guidelines for innovators and practitioners on how to use this technology. To do so, we will consider use-cases from diverse application areas that will drive the design and the development of the framework, and include several available planning systems as engines that can be selected to solve practical problems. We will develop a general and planner-agnostic API that will both be served by the AI4EU platform and be available as a resource to be integrated into the users' systems. The framework will be validated on use-cases both from within the consortium and recruited by means of cascade funding; moreover, standard interfaces between the framework and common industrial technologies will be developed and made available.

Keywords: planning and scheduling,decision making,systems integration,technological innovation
Molecular determination of Rif1-Associated Genomic Elements and their function in regulating genome activity and integrity (RAGES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-31
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

DNA double-strand breaks (DSBs) are highly toxic and must usually be accurately repaired to prevent oncogenic mutations. However, DSBs also represent necessary intermediates of recombination events required to create genetic diversity in immune repertoires and the germline. These distinct cellular contexts require that DSBs are differentially metabolised to achieve the required genetic outcome. Thus a complex system has evolved to regulate DSB repair. Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader. However, little is known about how these proteins cooperate to alter the chromatin landscape at DNA damage sites, and how this influences DNA repair decisions. Understanding the molecular basis of these proteins function is paramount, as misregulation at the level of Rif1/53BP1 is known to drive disease: loss of either protein results in primary immunodeficiency, while an inability to counteract Rif1/53BP1-dependent activities during DNA repair is associated with genomic instability that drives carcinogenesis. Interestingly, recent evidence suggests that Rif1 may also mediate gene-repression in certain chromatin contexts. This raises the possibility that the manner by which Rif1 regulates transcriptional control may be similar to its role in DNA repair. In this proposal, I seek to test my hypothesis that Rif1 mediates repressive chromatin states to regulate both transcription and DNA repair outcomes. My preliminary work and an array of unique cell lines and molecular reagents developed by my host laboratory, provide me with a unique and timely opportunity to examine this fascinating protein, and develop a better understanding of potentially common regulatory mechanisms that govern transcription and DNA repair.

Keywords: rif1,dna double strand breaks,class switch recombination,chromatin architecture,transcriptional regulation
Head protection: a European training network for Advanced Designs in Safety (HEADS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Ireland,Belgium,Sweden,Belgium,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3387265.56
EU funding (EUR): 3387265.56
Participants: 6
Project status: CLOSED

Head injury is the most severe injury caused by motorcycling, bicycling, snowsports and equestrian activities, and it is the leading cause of death within these activities. Linear acceleration has been used extensively to determine head injury risk, but it has been found that brain injury is actually influenced by angular kinematics. This is ignored by current injury criteria and product certification tests. To date, there is no consensus in terms of head injury due to angular kinematics and this represents a significant gap in the state of the art. The scientific goal of HEADS is to improve the understanding of head impact injury and to design new helmet standard test methods that recognise the influence of rotational kinematics. This will lead to improved helmets and a reduction in the severity of injuries and the numbers of fatalities. This objective will be achieved through a combination of computational simulations of real-life accidents, experimental and computational investigation of injury thresholds, and design of new helmet certification tests. Another major objective of the network is to train a group of highly specialised doctoral graduates who are equally cognisant of head impact biomechanics and helmet design technologies as well as being aware of commercialisable market opportunities. The ESRs will work in world-class facilities with highly qualified experts, and will benefit from the training scheme developed based on the expertise of academic and industrial partners. This project will reach a new level of understanding of head injury and how head injury should be prevented, with directly applicable results to European industry. It will develop a well-networked group of young engineers and scientists into world class researchers and innovators with numerous career paths open to them, who will advance technology for the benefit of society and maintain Europe as a global leader in industrial development.

Keywords: safety technology,biomaterials engineering,design engineering,simulation engineering,passive safety,helmets,head injury,standard testing,impact biomechanics
Decentralised Agile Coordination Across Supply Chains (DIGICOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Germany,Greece,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Digital automation (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 7993818.75
EU funding (EUR): 7993818.75
Participants: 14
Project status: CLOSED

European manufacturing competes in a global knowledge-driven economy, and thus increasingly seeks competitive advantage through quality, agility and personalisation based on latest advances in IT. Increasing utilisation of IT in mission-critical elements of the production brings opportunities for consistency, transparency and flexibility, bringing the “lot size of 1” closer to reality even for mass-production industries. Most relevant to achieve the expected increase of production performance for highly customized products is to master the complexity of the supply chain and logistics in the global production networks. Ad-hoc collaboration and setup of production coalitions with a wide spectrum of suppliers and service providers is necessary to answer the customization wishes of customers for their individual products in short time, high quality, and at affordable costs. Innovations from small high-tech companies requested by customers have to be integrated into the traditional industrial processes using novel organisational concepts and setups. DIGICOR will address the development of a collaboration platform, tools, and services for the setup and coordination of production networks and in particular the integration of non-traditional, small, yet innovative companies (SMEs) and logistics providers into the supply chain of large manufacturers (OEMs). The solution is based on an open platform integrating tools and services and implementing case specific governance rules and procedures for collaboration, knowledge protection, and security. The open platform will provide services creating a marketplace for the collaboration partners, for planning and control of the collaborative production and the logistics and risk management. It will be open to third parties to add services for advanced analytics, simulation, or optimization etc. The platform will provide seamless connectivity to the automation solutions, smart objects, and real-time data sources across the network
Mild Hybrid cOst effective solutions for a fast Market penetratiON (THOMSON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Germany,Italy,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Italy,France,United Kingdom,United Kingdom
Call: System and cost optimised hybridisation of road vehicles (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2020-03-31
Duration (months): 42.0
Total project cost (EUR): 11694311.43
EU funding (EUR): 9123957.51
Participants: 16
Project status: CLOSED

Mild Hybrid cOst effective solution for a fast Market penetratiON. THOMSON (Mild Hybrid cOst effective solutions for a fast Market penetration) project aims to the development of cost effective solutions, based on 48V architectures, answering the need in reducing the environmental impact of the transportation sector through a clever combination of advanced engines technologies, electrification and wider use of alternative/renewable fuels. The project addresses very precise and consistent objectives to support a quick transition towards high efficient, cleaner and affordable electrified powertrains focusing on the 48V architectures, intended as key element to increase fuel economy and reduce environmental impact and to support a quick penetration on the market of the hybrid powertrains. Approaches developed in the THOMSON project will demonstrate how the right combination of advanced engine downsizing/turbocharging technologies, coupled with a 48V motor-generator system, can provide the most cost effective solution for a rapid electrification through conventional vehicles. The project will provide an exhaustive evaluation of this concept through the development of two different 48V architectures (one integrating the e-machine on the front engine belt drive, the other between the engine and the transmission) on two different engine families: on one side a mid-size 1.6 litre Diesel engine and, on the other one, a small downsized Spark Ignited CNG engine equipped with a Direct Injection system. This twin approach will allow to demonstrate how 48V architecture interacts with Diesel technologies (especially with regard to noxious pollutant reduction) and, on the other side, with Spark Ignited CNG ones, emphasizing the CO2 reduction already achieved through the use of a low carbon fuel such as CNG. Moreover, for both engine families, 48V architecture represent an important enabler to introduce electrically driven auxiliaries and sub-systems leading to a global better man
Project: Scale up of CDC production for inclusion in ultracapacitor to double the performance. (SKLCarbonP2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Estonia
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2015, 2015)
Start date: 2016-04-01
End date: 2018-06-30
Duration (months): 27.0
Total project cost (EUR): 3555375.0
EU funding (EUR): 2488762.5
Participants: 1
Project status: CLOSED

Ultracapacitors (UC) are playing an increasingly important role as efficient high power energy storage devices. UC market has shown 30% CAGR since 2009. Leading consultancy IDTechEx estimates that by 2021 the directly addressable segment of large format ultracapacitors (over 100F) is forecast to reach $4bn USD. The same research identifies low energy and power density, together with high costs, as the main factors inhibiting further market growth. Skeleton Technologies (SKL) has developed a patented carbide derived carbon (CDC) UC technology, which enables a four-fold increase in power density (78 kW/L) and twice the energy density (20 Wh/L) and, approximately halving the cost/performance ratio. The competitive advantage in performance and system level savings has been verified by SKL´s customers ABB, Bosch, Continental, BMW, Audi. SKL go-to-market strategy focuses on European customers in the industrial equipment, power grid and transportation industries. The revenue ramp-up plan is based on quantities and pricing information from numerous LOI´s and contracts with the pilot customers and fits the geographical and industry focus of SKL´s strategy. With 47 employees, incl. 9 PhD´s as the research core, and robust backing from strategic and private equity investors, SKL has the facilities and investments in place for UC production ramp-up. The aim of this project is to develop the technology necessary for CDC production in industrial scale to provide raw material for UC production and underpin the SKL performance advantage. The technological challenge is scaling CDC production from TRL 6 by deploying large-scale fluidized bed reactors at a partner manufacturer site to achieve TRL 8. Toll manufacturer will supply the material to SKL for electrode and UC production as the next step in the value chain, while ST retains control of IP. Product-to-market fit will be ensured by extensive testing with SKL´s customers to fine-tune the cost/performance ratio.
Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation (Signalling-in-NODs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Inflammatory bowel disease (IBD) is a complex chronic pathology in western societies. There is an unmet need for new therapeutic strategies which can only be achieved through a better understanding of the molecular mechanisms of host immunity. It is established that dysregulated host innate immune recognition either caused by genetic risk variants in pathogen recognition receptor (PRR) molecules or microbial factors is commonly associated with IBD. A unique PRR family member, Nucleotide oligomerization domain (NOD)2 programs gut immunity and protection through autophagy process initiated by the recognition of microbial peptides. Deleterious mutations in NOD2 and autophagy-associated proteins are linked to IBD susceptibility. Despite the advances made in understanding of the mechanisms underlying NOD2 biology, particularly that of autophagy, very little is known about the cell signaling components and their mechanism regulating autophagy under NOD2 pathway. Recently, I discovered that a single Phosphoinositide 3-kinases (PI3K) isoform p110δ is integrated in NOD2 mediated autophagy process. PI3Ks are an evolutionarily conserved family of signaling molecules that integrate PRR signaling. PI3Ks generate lipid second messengers and regulate mediated immune responses. I now propose to unravel key biological phenomenon by which p110δ PI3K convey host protective functions through NOD2-mediated autophagy, ensuring the gut immunity and tolerance. The aims are to (1) Determine the dendritic cell-intrinsic role and mechanism(s) of action of PI3K isoforms in orchestrating anti-inflammatory processes under NOD2-mediated autophagy. (2) Discover the roles of PI3K isoforms in NLR-mediated intestinal immunity using isoform specific PI3K gene-targeted mice alongside with pharmacological targeting strategies in vivo. My plan is integrated with animal models, immunology, cell biology, microbiology and in vivo inflammation studies to elucidate key biological phenomena driving IBD.

Keywords: phosphoinositide 3 kinases,colitis,inflammation,nods,dendritic cells,regulatory t cells,tolerance,omvs
Internet of Radio Light (IoRL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Israel,Spain,Germany,Spain,Germany,Poland,China,Türkiye,Greece,France,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: 5G PPP Research and Validation of critical technologies and systems (H2020-ICT-2016-2, 2016)
Start date: 2017-06-01
End date: 2020-11-30
Duration (months): 42.0
Total project cost (EUR): 8604923.75
EU funding (EUR): 7685423.75
Participants: 23
Project status: CLOSED

Wireless networks in buildings suffer from congestion, interference, security and safety concerns, restricted propagation and poor in-door location accuracy. The Internet of Radio-Light (IoRL) project develops a safer, more secure, customizable and intelligent building network that reliably delivers increased throughput (greater than 10Gbps) from access points pervasively located within buildings, whilst minimizing interference and harmful EM exposure and providing location accuracy of less than 10 cm. It thereby shows how to solve the problem of broadband wireless access in buildings and promotes the establishment of a global standard in ITU. Building landlords will be incentivized to find funding to realize this solution for their properties to increase their value resulting in a stimulated market for broadband networking products in buildings, benefiting society and stimulating the world Gross Domestic Product. IoRL project provides solutions to the two main barriers to develop this broadband networking solution in buildings because it: (i) Brings together a multi-disciplinary team of research institutions and industries in a collaborative project to develop and demonstrate this vision, who otherwise would not have assembled to achieve this goal; (ii) Develops a proof of concept demonstrator, which will act as the basis for standardization of a global solution. The starting point is the joint VLC demonstrator at Tsinghua University & ISEP, the mmWave at Cobham Wireless and the NFV/SDN at NCSR-Democratos. The challenges are to (i) Develop broadband communication solutions for buildings by integrating these technologies to exploit the pervasiveness and accessibility of the existing electric light access points, the broadband capacities of mmWave and VLC technologies and the flexibility of SDN/NFV; (ii) Industrially design a radio-light solution that can be integrated into the myriad of form factors of existing electric light systems and consumer products.

Keywords: visible light communications