Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Local Optoelectronic Visualisation for Enhancing Tandem Perovskite/Silicon Solar Cells (LOVETandemSolar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-05-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

To ensure that Europe reaches its 2030 Climate & Energy targets, including 27% renewable energy capacity on the grid, society must accelerate the deployment of photovoltaics (PV). Thus, developing new solar energy harvesting solutions with enhanced performance is essential. Silicon (Si) devices currently dominate 90% of the PV market share and have a standard operational efficiency (η) of 20-25%. To boost this performance, researchers are fabricating multijunction solar cells, i.e. introducing a tuneable-bandgap perovskite PV material on top of the Si. By creating this dual junction device, the practical η jumps to 30-35%, dramatically reducing the cost/Watt of the existing commercialized technologies. Yet, little is known about how the electrical and optical properties of the perovskite and Si layers influence one another or whether the present microscale pyramidal patterning of Si needs to be re-optimised for multijunction architectures. The main objective in this project is to probe the optoelectronic interactions of next-generation PV devices to capture the intricate optical interplay between the perovskite and Si. By leveraging the Researcher’s expertise in implementing/conducting functional microscopy experiments, the Host will learn cutting-edge techniques based on scanning probe and optical microscopes. Meanwhile, working with Dr. Sam Stranks at the University of Cambridge offers an unparalleled opportunity for the Researcher to acquire knowledge about novel optical spectroscopy imaging methods as well as perovskite device synthesis. Researching at Cambridge will also encourage international collaborations with world-renowned scientists. The transfer of knowledge between the Researcher and Host will lead to optimised perovskite/Si tandem solar cells with η exceeding the current state-of-the-art PV devices. Such results will undoubtedly promote further solar energy adoption, helping Europe uphold a competitive, secure, and sustainable electrical grid.

Keywords: solar cells,perovskites,microscopy,photovoltaics,functional imaging,big data
Symmetries and Degrees of Freedom in Cosmic Epochs of Accelerated Expansion (SymAcc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: CLOSED

Through theory and observations, it is well established that the universe undergoes accelerated expansion in its history. This accelerated expansion takes place in two different epochs. The first of these is the early epoch of inflation and the second is the current epoch of dark energy domination. Although methods of General Relativity, which is the classical theory of gravity, and Quantum Field Theory, which addresses matter interactions at quantum scales, have guided much of our understanding of the universe, they cannot fully address these epochs of accelerated expansion. In this project the objective is to identify the cosmological degrees of freedom that have a crucial role during inflation and dark energy. It proposes to achieve this goal by studying the ideal case of a spacetime that gives accelerated expansion, using recent methods in holography in order to (i) identify specific deformations from the ideal case that give rise to the cosmological degrees of freedom during inflation and dark energy separately; (ii) explore the generality of these deformations and their cosmological consequences using methods of renormalization group flows; (iii) address deformations in the context of time dependent and space dependent evolution separately to further improve the understanding on the nature of cosmological degrees of freedom. This interdisciplinary project proposes to use the principle of holography from String Theory which can open up a new way of studying cosmological perturbations, especially in the context of dark energy. By focusing on cosmological spacetimes, it will also address the validity of holography in new settings.

Keywords: cosmology,high energy theory,inflation,dark energy,effective field theory,conformal field theory
Upward mantle flow from novel seismic observations (UPFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom,Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2843038.0
EU funding (EUR): 1855419.25
Participants: 2
Project status: SIGNED

While downward mantle flow (subduction) is well constrained, a grand challenge in Earth sciences is to understand deep upward flow that cannot be explained by plate tectonics. The aim of UPFLOW is to develop an entirely new seismic imaging approach and to use it to constrain plume-like mantle upwellings at unprecendented resolution. Upward flow is critical for continental growth, for returning volatiles to the atmosphere and for producing Earth's largest melting events. These events coincide with major extinctions, supercontinent breakups and with changes in geodynamo behaviour. Seismology has come far by using travel-time and waveform (phase) information but has mostly ignored the amplitude information. Mantle plumes have just started to be robustly imaged, yet resolution is low and uncertainty quantification is lacking. I developed breakthrough seismic imaging methods based on big amplitude data, showing their strong resolution. With recent computing resources and explosion in datasets, it is now timely to use this unique expertise to lead a step change in observational seismology: rather than relying on pre-defined observables (e.g., travel-times), objective statistical techniques exploring the full richness of the data will be used to design observables that provide optimal constraints on Earth structure. I will lead a new off-shore experiment in the Azores-Madeira-Canary islands region, which is an under-studied natural laboratory comprising significant mantle upwellings that are poorly understood in general. The imaging technique to be developed will be applied to these new data and to existing data (Hawaii, Reunion) to obtain the sharpest ever images of mantle plumes along with their interdisciplinary interpretation. These results will have a major impact far beyond the study regions and across Earth Sciences (e.g., geology, geochemistry, geodynamics) since they will reveal ubiquitous, fundamental phenomena that control the global evolution of the planet.

Keywords: mantle plumes,seismic imaging
A Promising Treatment of WWOX Associated Neurological Disorders (WWOXAID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-08-01
End date: 2022-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

A Promising Treatment of WWOX Associated Neurological Disorders WWOXAID WWOX-related epileptic encephalopathy (WOREE) syndrome, also known as early infantile epileptic encephalopathy, 28 (EIEE28, OMIM: 616211), is a very severe epileptic encephalopathy characterized by absence of language development and acquisition of walking, early-onset drug-resistant seizures, ophthalmological involvement, and a very high likelihood of premature death. Above all, WWOXAID aims to set the basis for bringing into clinical development a treatment for WOREE syndrome affecting children in infancy. Although WOREE syndrome has very limited market prospects, since the number of known patients is low and no current active registry is available, this development is critical because there is no current treatment that could save children with WOREE. In addition to this highly humanitarian purpose, we are confident that this PoC achievement shall be also of importance for broadening the spectrum of applications of this treatment in other WWOX-related disorders. In this PoC, we will achieve several necessary steps including the generation, characterization and delivery of the vectors, securing IPRs, conducting a specific market assessment, targeting regulatory constraints, implementing a business development plan, consulting with professionals in the field and developing contacts with the industry, dedicated organizations and medical doctors.

Keywords: woree,aav9,epilepsy,wwox
Complexity and Condition in Algebra and Numerics (COCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2297163.0
EU funding (EUR): 2297163.0
Participants: 1
Project status: SIGNED

This proposal connects three areas that are considered distant from each other: computational complexity, algebraic geometry, and numerics. In the last decade, it became clear that the fundamental questions of computational complexity (P vs NP) should be studied in algebraic settings, linking them to problems in algebraic geometry. Recent progress on this challenging and very difficult questions led to surprising progress in computational invariant theory, which we want to explore thoroughly. We expect this to lead to solutions of computational problems in invariant theory that currently are considered infeasible. The complexity of Hilbert's null cone (the set of "singular objects'') appears of paramount importance here. These investigations will also shed new light on the foundational questions of algebraic complexity theory. As an essential new ingredient to achieve this, we will tackle the arising algebraic computational problems by means of approximate numeric computations, taking into account the concept of numerical condition. A related goal of the proposal is to develop a theory of efficient and numerically stable algorithms in algebraic geometry that reflects the properties of structured systems of polynomial equations, possibly with singularities. While there are various heuristics, a satisfactory theory so far only exists for unstructured systems over the complex numbers (recent solution of Smale's 17th problem), which seriously limits its range of applications. In this framework, the quality of numerical algorithms is gauged by a probabilistic analysis that shows small average (or smoothed) running time. One of the main challenges here consists of a probabilistic study of random structured polynomial systems. We will also develop and analyze numerical algorithms for finding or describing the set of real solutions, e.g., in terms of their homology.

Keywords: algebraic complexity theory,computational invariant theory,condition numbers,homotopy methods,probabilistic analysis of numerical algorithms
Generation of a business plan for the production of a compact and reliable device able to measure in real-time the cerebral workload state of high responsibility operators in the transport domain (BrainWorkloadReader)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The present proposal aims to generate a business plan related to the realization and commercialization of an already developed prototype able to track in real-time the cerebral workload of aircraft pilots or other operators in the transport domain. Such operators could be for instance the Air Traffic Controllers (ATCos) or those devoted to control the traffic of an high speed train network or subway. The developed device, named BrainWorkloadReader (BWR) will be used: i) during training-assessment programs, to quantify the progress of the learners in terms of amount of cognitive resources requested during simulated or real tasks; ii) during the normal daily activities of an operator in order to monitor in real time his/her cerebral workload for traffic control of airplanes, trains or cars in specialized control rooms. The BWR device consists in a easy wearable cap with 6-8 electrodes connected in a wireless way to a portable recording systems. The already developed prototype has the size of a smartphone and it is able to return information about the level of cognitive workload of the operator (e.g pilots, ATCos etc etc). The BWR device has no counterpart actually in the market, and its role will be not limited to the transport domain but it is potentially applicable in every situation in the close future in which there will be an operator and a task to be performed. This means that it will be possible to measure the level of cerebral effort across different contexts, including operators in remote surveillance tasks, etc. etc. Possible applications will be in any environment in which a human has to monitor a system or a process and in which the occurrence of an error due to the excessive operator’s workload could have significant consequences for the safety of both the operators and other human subjects.

Keywords: cerebral workload,flight simulators,airline pilots
A drug discovery platform for early human embryogenesis. (BLASTOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The first weeks of human embryonic development are crucial. Early abnormalities or insults result not only in infertility, but also contribute to long-term impairment of human health (e.g., cardiovascular disease and diabetes). Managing the onset of pregnancy therefore offers a huge opportunity to improve public health through effective family planning and disease prevention. To better manage pregnancy, biomedical research would require large numbers of human embryos for use in genetic and drug screening. Unfortunately, however, the scarcity of human embryos makes this impossible. Recently, hope for an alternative approach has come from work in my lab showing that mouse stem cells self-organize into structures closely resembling pre-implantation embryos (a.k.a. blastocysts), that we termed blastoids. Because stem cells can be largely expanded and genetically-modified, these synthetic embryos provide a powerful, scalable alternative that is amenable to drug and genetic screens, thus opening numerous possibilities for therapeutic breakthroughs. Here, I propose the development of human blastoids and uterine organoids to model embryogenesis and uterine implantation in vitro. This platform will be used to identify potential targets for the therapeutic modulation of the molecular pathways that control (1) early embryogenesis and (2) interactions between the embryo and uterus, and will pave the way to (3) establishing a drug discovery pipeline for the management of implantation. This project will generate key insights into druggable molecules controlling early human embryogenesis, facilitating identification of therapeutic targets to improve in vitro fertilization (IVF) procedures and contraception and, ultimately, to prevent several chronic diseases.
Supporting Transnational Start-up Ecosystems (TransUP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Austria,Italy,Slovenia,Slovenia,Croatia
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2016-04-01
End date: 2017-03-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 5
Project status: CLOSED

Although EU programmes and policy makers have been encouraging the potential for cooperation between different startup ecosystems - including within the Alpe Adria region-, still no strong coordination mechanisms yet exist that would ensure a streamlining between regional, national and EU initiatives in support of innovative businesses. The basic TransUP concept is to tackle the challenge of making the Alpe Adria region an attractive hub for innovative entrepreneurs and investors, where the ecosystem made of actors and services devoted to support the creation and development of new businesses is really collaborative and transnational. Technology startups in the peripheral European territories like the Alpine Adriatic usually look to Western Europe or to the USA rather than to neighboring countries for models of change and development. The overall objective of the TransUP project is thus to collaboratively address a common innovation support challenge and to peer-review transnational support services and co-design an innovative and systemic Crossregional Softlanding Programme for enhancing a multicultural and international driven attitude among startups in order to improve their survival chances on the global market. The Crossregional Softlanding Programme is aimed at offering to startups from neighboring regions Carinthia (Austria), Friuli Venezia Giulia (Italy), Slovenia and the newly entered EU member state Croatia, the possibility to develop their company within a multicultural environment. The expected result is the activation of a comprehensive international attitude in all aspects of startup business management with positive effects from market reach to competitive strength. Specific focus will be dedicated to startups with reference to the Alpe Adria region but the recommendations developed in the Design Option Paper will be valid for all sectors and EU geographical location.

Keywords: start up,softlanding,service design delivery,new entrepreneurs
Species Responses to Climate Change in the Amazon To Andes region (RESCATA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2024-06-10
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Tropical forests face an extinction crisis. Increasing temperatures and drought events jeopardize the survival of thousands of plant species, and the response of tropical forests and their species to climate change is one of the most pressing current questions in Ecology. The Andes and the Amazon are among the most important ecosystems on Earth in terms of carbon storage, biodiversity, and climate regulation. However, despite being adjacent and contiguous ecosystems, they have been studied as distinct entities and thus, our knowledge on regional ecosystem processes and species-level distribution and dynamics is truncated, limiting our ability to understand the effects of climate change in these forests. In RESCATA, I will combine ¬– for the first time– the world’s largest networks of Andean and Amazonian vegetation monitoring plots (RAINFOR and sANDES) and perform innovative species-level analyses. The goal is to identify the drivers behind plant species survival or extinction under climate change conditions in the Amazon-Andes region and to reveal ongoing and future macroecological changes in these forests. We will test the role of initial species abundance, distribution range, functional traits, and phylogeny on species success or failure. In addition, we will pioneer the standardization of Andean and Amazonian data in order to increase usage, collaboration and accuracy. Fadrique will work alongside world-leading researchers Prof. Phillips and Prof. Cayuela in order to gain macroecological knowledge, alongside new skills in big-data analysis and individual-based modelling as well as multidisciplinary connections to establish herself as a leading climate-change scientist in Europe. The results of this project will be of high interest far beyond the scientific community including government entities, policy makers, conservation agencies and the general public and I will engage them via different activities such as publications, policy reports, webinars and workshops

Keywords: plant species,tropical forests,species success,carbon storage,functional traits,biodiversity,extinction