Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Universal Acoustic Digital Light Processing 3D Printing (UniADLP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

3D printing, or additive manufacturing, has the potential to drastically transform fields such as architecture, aviation, sportswear, robotics, biomedical devices, implants, and tissue engineering. There is an increasing demand for 3D printing of reinforced composites and biological architectures. The 3D printing of composites is technically challenging due to the need to controllably orient and print microparticles. Commonly used 3D printing technologies achieve customizable prototypes using only a single material, and to date, few printers permit the incorporation of microparticles and living cells. Consequently, current methods allow only limited customization of the mechanical properties of printed objects. Acoustics permit microparticles to be manipulated noninvasively. In this proposal, UniADLP, we will develop a novel acoustic-based 3D printer with which microparticles can be aligned and selectively polymerized to develop a user-defined 3D printed object. We will assimilate homogeneous and heterogeneous microparticles while dynamically orienting them during the printing. This proposal will open up a new and exciting area in the field of additive manufacturing, using ultrasound to print reinforced architectures.

Keywords: acoustics,ultrasound,microparticle manipulation,3d printing
Solving global warming through direct air capture Establishing a 400-Tonne Direct Air Capture Facility in Arad, Romania: Utilising Waste Heat to Revolutionise Carbon Capture and Drive the Low-Carbon (AVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1356617.0
EU funding (EUR): 1356617.0
Participants: 1
Project status: SIGNED

AVE's direct air capture (DAC) technology offers a cost-effective and energy-efficient solution to reduce global CO2 levels. Its unique systems capture CO2 directly from the air and store it safely, contributing significantly to mitigating climate change. The DAC units are scalable and adaptable, allowing deployment in diverse settings. AVE's technology stands out for its superior performance, adaptability and cost-effectiveness. By deploying these units widely, AVE aims to foster sustainability and economic resilience, making a significant contribution to global CO2 reduction efforts.

Keywords: direct air capture,low carbon,global warming,
AI-based profiling of kidney tissue to improve patient outcomes and accelerate drug discovery (NephroPath)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2484594.0
EU funding (EUR): 2484594.0
Participants: 1
Project status: SIGNED

The global incidence of kidney disease is rising, already impacting 850 million people worldwide. Precise analysis of kidney tissue is key for determining the most optimal treatment for patients. However, 86% of countries worldwide suffer from a shortage of nephropathologists, with even 100% in low-income nations. Additionally, human based assessment in kidney pathology suffers from low interobserver agreement. This not only affects diagnostics, but also limits efficiency and throughput of (pre)clinical trials. Aiosyn's NephroPath platform addresses these issues through it’s artificial intelligence (AI) platform, providing quantitative analysis of kidney biopsies. Our platform facilitates a more standardized and scalable approach to diagnosing kidney pathology, crucial for accurate and fast patient diagnosis, treatment and drug discovery. Our strategy encompasses three core objectives: firstly, we aim to scale our offering for preclinical kidney drug discovery trials. Targeted at Contract Research Organizations (CROs), we offer AI-based assessments with the goal of providing objective and quantitative measures for more efficient drug efficacy studies. Secondly, we extend the platform to clinical trials, enhancing the accuracy of biomarker-targeted patient inclusion and endpoint assessment. Lastly, we aim to secure CE-IVDR certification for NephroPath to enter the clinical diagnostics market. To achieve this, we conduct a multi-center clinical trial to validate its efficacy and accuracy, facilitating its adoption into routine clinical practice and improving the diagnostic processes within healthcare facilities across the EU. With a solid foundation in AI-driven diagnostic solutions and a clear path to market expansion, Aiosyn is set to impact kidney disease treatment and drug discovery. This project, backed by the EIC Accelerator, will accelerate our product development timeline and market leadership in the digital pathology and AI field.

Keywords: artificial intelligence,digital pathology,kidney disease
Africa’s Silicon Landscapes: negotiating Information and Communication Technology in Lagos (LAGOSTECH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 266684.16
EU funding (EUR): 266684.16
Participants: 2
Project status: SIGNED

To improve our understanding of the interactions and negotiations between society and Information and Communication Technologies (ICTs) in sub-Saharan African ‘silicon places’, LAGOSTECH will investigate the experiences of technology in and the digital creativity emanating from two technological nodes (Yaba and Talent City) in Lagos. Nigeria is home to the largest number of tech hubs in Africa, but paradoxically is also where silicon places have received the least scholarly attention. Studies of Silicon Valley reveal how ‘technologically saturated’ places strongly influence social relationships and individual experiences while producing a variety of perceptions of technology. Yet, despite the EU’s strong interest in digitalisation processes in Africa, previous studies on African technological nodes focused on entrepreneurs’ investment strategies within tech hubs, paying scarce attention to high-tech communities’ socio-cultural characteristics and to the broader reasons behind their development. LAGOSTECH aims to fill this gap by analysing Lagos innovation clusters in everyday life, with a focus on the negotiation of ‘technology contracts’; that is, the social dynamics through which ICTs are accepted, amended or rejected, ultimately leading to the emergence or the disappearance of these communities. Through ethnographic fieldwork, LAGOSTECH will look at the stories, discourses, and practices of tech entrepreneurs, experts, users and consumers, revealing how they imagine their digital futures and the interweaving between people and ICTs. In addition to advancing knowledge in disciplines such as Anthropology, Sociology, African Studies, STS, and Silicon Valley studies, the project’s findings will facilitate a broader reconsideration of ICTs in Africa, leading to improved collaboration between European and sub-Saharan African stakeholders.

Keywords: social and cultural anthropology technology icts internet silicon valley tech hub african studies sts,creativity innovation social dynamism computers technology contracts nigeria lagos
Science-based INtegrated FORest Mitigation mAnagement made operational for Europe (INFORMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Spain,Finland,Netherlands,Romania,Germany,Belgium,Austria,France
Call: Enhancing science-based knowledge on EU forests’, including old-growth forests, capacities to mitigate climate change (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 5337547.5
EU funding (EUR): 5337547.5
Participants: 15
Project status: SIGNED

Forests represent the largest terrestrial carbon sink that can be economically managed to combat climate change. In this context, sustainable forest management will become a major tool of the EU Green Deal on the road to an economic growth decoupled from resource use. But essential forest functions are increasingly threatened by climate change and related natural disturbances, while the knowledge regarding the effects of forest management on biophysical and biogeochemical fluxes exchanged between land and atmosphere are too limited. Accordingly, the overall objective of the INFORMA project is to increase the science-based knowledge on multi-purpose sustainable forest management under climate change. More particularly, it will analyse the trade-offs and synergies between different objectives considering the environmental integrity and climate feedbacks, social acceptability and economic feasibility of future European forest practices, including zero management options. It will identify options for maintaining carbon sinks, in addition to fostering productivity, supporting genetic diversity, biodiversity conservation, and maintaining soil and water resources in the different European ecoregions. Applying a multi-actor approach, INFORMA will 1) Quantify differences in major ecosystem functions affecting climate processes between managed and unmanaged forests across Europe; 2) Analyse socio-institutional patterns of innovative forest-based mitigation and adaptation strategies; 3) Search for management alternatives (including no-management) and simulate their effect on a variety of ecosystem functions; and 4) Improve forest carbon certification for a cost-effective operationalisation and integration of climate smart practices in forestry. INFORMA main outputs will be best regional management practices, implementation pathways for the European forestry sector, recommendations for forest carbon certification improvements and for economic-institutional policy action.

Keywords: global warming forest climate interactions forest function forest growth modelling sustainable forest management unmanaged forest forest carbon certification
EnAbling a Model-driven deep understAnding of the roLe of gender Towards a Holistic solution against Extremism and radicalization Activities (AMALTHEA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Romania,Greece,France,Italy,Cyprus,Luxembourg,Spain,Moldova, Republic of,Canada
Call: Radicalisation and gender (HORIZON-CL3-2024-FCT-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 3114566.25
EU funding (EUR): 3114566.25
Participants: 15
Project status: SIGNED

Recent scholarship on y the gender dimension in preventing and countering violent extremism programming, still lacks thorough gender-sensitive data collection and analysis. On the one hand, empirical data and a gender-sensitive approach in counter violent extremism is needed to create lasting security. On the other hand, violent extremism concept does not have an agreed definition. The literature on Traditional Counterterrorism (TC) policy has been conducted from a gender-blind perspective, at the most adding women and “stirring” them into the existent mix, instead of meaningfully re-examining the underlying issues of gender and diversity dynamics. In this context, it is important to critically examine how the unequal socialization can lead to violence and become a driver of VE (Violent Extremism) by bringing in the feminist and intersectional perspectives into research design, data collection and analysis. A better understanding of the causes, manifestations, and mitigation practices of violent extremism is required, by critically examining the relationship between gender and extremism, investigating gender-specific factors for radicalization, such as community belonging, social connections, traumas or empowerment narratives. AMALTHEA will address the challenge of limited access to knowledge, collaboration and unified approaches against gender-related radicalisation via in-depth research and delivery of innovation in three complementary fields: (i) Knowledge creation, targeting LEAs, CSOs, social support professionals, teachers and other P/CVE practitioners; (ii) Knowledge modelling, management and sharing to improve understanding of the role of gender in VE/CVE; and (iii) Tailor-made tools for LEAs and CSOs that will enable engagement, collaboration, efficient policy making and optimised decision making towards de-radicalisation.

Keywords: gender related extremism knowledge creation,management and sharing tools for leas and csos for training,capacity building and de radicalisation
Light elements in the core (LECOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2067194.0
EU funding (EUR): 2067194.0
Participants: 1
Project status: SIGNED

Since the discovery of the Earth’s internal structure and the existence of a dense metallic core about a century ago, the idea of iron being the dominant component of the core gained firm support confirmed by cosmochemical and geochemical observations, seismic data, the theory of geomagnetism, and high-pressure studies. However, although closely matching, the velocities of seismic waves traveling through the core are significantly slower than those in a pure iron-nickel alloy. The observed core density- and velocity- deficit suggest that around 3-7 wt% of the light element(s) should be present in the inner core in order to explain the observed mismatch. Moreover, the inner core is anisotropic, with the compressional waves traveling faster along the polar axis than in the equatorial plane. Thus, the candidate material should be also able to explain the observed anisotropic pattern. Nonetheless, the nature of the light element(s) in the core remains unconstrained, with hydrogen, carbon, oxygen, silicon, and sulfur being the most plausible candidates. The laboratory measurements on the physical properties of some candidate materials at high pressures and room temperature are available in the literature, but data at simultaneous high pressures and temperatures as most relevant to the Earth core are almost absent. In LECOR, we aim to identify the most plausible candidate element, extending state-of-the-art measurement techniques considerably. In particular, we will study the elasticity and plastic deformation mechanisms of candidate binary and ternary iron alloys and compounds in situ at extreme pressure-temperature conditions using a combination of state-of-the-art synchrotron X-ray techniques developed in our group. We will interpret this novel data within the most recent geophysical and geochemical models, to better determine the composition of the Earth’s core. Such would open fascinating avenues to refine theories about the formation of planets, in general.

Keywords: earth s inner core sound velocities core anisotropy extreme pressure temperature conditions
The role of transposable elements in human brain evolution (brainTEaser)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-05-31
Duration (months): 32.0
Total project cost (EUR): 210187.68
EU funding (EUR): 210187.68
Participants: 1
Project status: SIGNED

The human brain is the largest and most complex of all primates possessing unique cognitive functions but also suffering from neurological disorders. However, little is known about primate brain development and the modifications enabling brain enlargement as primate tissues are not available at early developmental time points. Only few changes occurred in protein-coding genes; thus, significant differences must be present in gene regulatory processes. It is essential to analyse primate models to identify and understand molecular features unique to the human brain. Transposable elements (TEs) are mobile pieces of DNA comprising 50% of primate genomes. They can contribute to genome evolution as they carry regulatory sequences and have been found to serve for example, as enhancers and alternative promoters. Moreover, TEs are insertional mutagens leading to genetic disease. They are silenced by repressive marks including DNA methylation. Interestingly, methylation can sometimes spread and impact adjacent regions making TEs noteworthy candidates for methylome evolution. Due to their challenging analysis and lack of primate material, the role of TEs in primate brain development and human brain evolution has not been investigated thoroughly. Here, I propose that human-specific TE insertions have the capacity to act as repressors and silence genes in brain development. Exploiting human and non-human primate cerebral organoids as a model for brain development, and Oxford Nanopore Technologies long-read DNA sequencing to detect DNA methylation, I will analyse locus-specific TE methylation spread to nearby genes. Using differential expression analysis and CRISPR-Cas9 genome editing, I will assess the effect of putative repressor TEs on gene expression revealing if the repression of specific loci contributed to human brain enlargement and gain of cognitive functions.

Keywords: transposable element,te,retrotransposon,dna methylation,epigenetics,nanopore sequencing,oxford nanopore technologies,cerebral organoids,neuronal differentiation,crispr cas9
Sensor islet organoids (SILORGS) for in vivo identification of anti-diabetic drugs (SILORGS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant genetically engineered sensor islet organoids into the anterior chamber of the eye of mice for functional microscopic imaging. Using the cornea as a natural body-window, following their engraftment various aspects of β-cell function and survival can be readily imaged in these organoids. Functional studies demonstrate that engrafted islet organoids in the eye respond to the diabetic milieu of diabetic mouse models. We have extensively in vitro tested fluorescent biosensors that reflect key-events in β-cell function and survival. Following intraocular transplantation of mouse and human islet organoids expressing biosensors in their β-cells into healthy or diabetic mice, they will allow non-invasive, longitudinal in vivo monitoring of 1) glucose responsiveness, 2) Ca2+ handling, 3) functional β-cell mass, and 4) proliferation. Based on the in vitro tested biosensors, the major objective is to establish a robust pharma-industry in vivo imaging platform for validating newly developed diabetes treatment lead-compounds in early drug development. This screening service shall be performed on a commercial basis. The milestone of this proposal, to be achieved within 18 months, is the validation of the sensor islet organoid-based in vivo platform for testing the effects of new potential diabetes medicines on human β-cell function and survival in normal and diabetic mice.
Mastering Electronic Doping in Tin-Halide Perovskites to Develop Near Infrared Light Emitting Diodes (MaDLED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

As a key advancing technology, near-infrared light-emitting diodes (NIR-LEDs) cover nearly all aspects of our daily life due to their supported large applications, such as biomedical imaging, optical communication, security, and data storage. With extensive efforts, the efficiencies of LEDs have been improved by over 20% in the emission range below 800 nm. However, the development of NIR-LEDs over 800 nm is modest due to the fundamental limitation of emitters. Recently, tin-halide perovskites (THPs) have emerged as one of the most promising candidates for NIR-LED application. Through easy composition engineering, the emission of THPs can be readily tuned from 680 nm to 1000 nm. Meanwhile, the low-toxic Sn-based perovskites follow the requirements of the European Green Deal, which ask for reducing pollution to enhance the protection of human life, animals, and plants. However, the excessively high p-type doping in THPs, which reduce the carrier injection efficiency and radiative recombination efficiency, currently limits the development of THP-based NIR-LEDs. This project (MaDLED) will promote the development of NIR-LEDs by developing novel strategies to increase carrier injection and recombination efficiency. The results of this project will advance the knowledge about NIR emissive semiconductors, and be of value in other fields, such as solar cells, detects, transistors, etc. This will be achieved by integrating deep knowledge of materials science with expertise in advanced optical-electronic spectroscopies in the host (Istituto Italiano di Tecnologia, Italy). Besides, a secondment (Helio Display Materials, United Kingdom) is planned to define a suitable route to industrialization. After training in this project, I will have an increased set of research and transferable skills and competencies, which is critical to enhancing my employability and career prospects.

Keywords: near infrared,light emitting diodes,spectroscopy,thin film,device architecture