Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Let’s discover 2007 underwater mysteries (2007UWM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-07-01
End date: 2007-10-31
Duration (months): 4.0
Total project cost (EUR): 75000.0
EU funding (EUR): 40000.0
Participants: 1
Project status: CLOSED

Up to date, the wider Greek public is not enough aware of the significant achievements of the Greek scientific community and consequently marine research professions are not chosen. The overall goal of the project is an opening of the unique Hellenic Centre for Marine Research to the public, aiming at their familiarization and sensitization with marine research and its technology, by focusing on the following objectives to: Propagate the recent knowledge of the marine environment to the public Popularise research results, which include direct profits in the daily life Increase the communication between researchers and the public Familiarize young people with marine science and technology issues, to stimulate their interest in researcher’s profession Target groups are school pupils, students, Local Authorities and the public in general. Events will be organised on the R/V “Aegaio” and at the Lavrio harbour (Attica). Land-based information activities will include various exhibits in special info kiosks, Videos, drawing and photo contest, children experiments, games and theatre, distribution of printed, electronic material, small gifts etc. On the R/V, visitors will be able to get to know more about the ship "Aegean", the submersible and the Remote Operated Vehicles of the Centre; sampling gears; the application and use of new technologies (e.g. program "Poseidon" for weather forecasting) as well as the possibility of access to scientific handbooks for the identification of marine organisms with the guidance of experts, which are simple examples of live communication that we expect to achieve. The simultaneous follow-up of the event, with the use of live connection, in two other different geographic regions (Crete and Rhodes, where the Aquaria of the Centre are located), will play an important role. After an appropriate awareness campaign, a large participation of the public is expected, which might be quantified and evaluated as described in the related WP.

Keywords: marine research,public awareness,sensitivity,public-researchers communication,profession interest
Researchers are Stars for One Night (REASON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy,Italy
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-06-01
End date: 2007-11-30
Duration (months): 6.0
Total project cost (EUR): 92360.0
EU funding (EUR): 70000.0
Participants: 6
Project status: CLOSED

The Researchers are Stars for one Night (ReaSON) project aims to increase awareness of the fact that scientific research is a very useful and practical contribution to the development of society and that researchers are “ordinary people” who are doing a very interesting and important job. The challenge for the project is to communicate and to practically demonstrate to the large public that the researchers’ career is driven by curiosity and creativity and research laboratories are places where these qualities are valorised. This should contribute to further reduce the gap between the large public and the research community. Interactive public participation in all the Researchers' night activities - especially through enabling children and young people to “play” researcher under the guidance of well known and experienced researchers and by showing that scientific research has very close links with daily life experiences of which we are not always completely aware - will convince people that scientific careers are fascinating and will stimulate young people’s interest in a scientific career. The Consortium has planned synergic activities exploiting partners’ complementary expertise and knowledge. The event, jointly designed by all partners and scientific supporters, will take place in four of the most important towns in Piedmont: Turin, Alessandria, Vercelli and Biella. An active role is played by researchers of various universities in Piedmont at all stages of the project, preparation, implementation, and evaluation and dissemination. The project partners will build on the experiences made in organising the very successful Researchers’ Night 2006 and on the regional networks that were developed to involve all the major regional stakeholders in the organisation of the Olympic Winter Games 2005.

Keywords: science and society,importance of researchers in society,popularisation of research,youth and science,citizens and science,promoting research careers,mass event,scientific communication
Science Alive: Researchers’ Night 2007 in Slovakia (RN2007SVK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Slovakia
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-06-01
End date: 2007-12-31
Duration (months): 7.0
Total project cost (EUR): 59600.0
EU funding (EUR): 53300.0
Participants: 3
Project status: CLOSED

In Slovakia, majority of researchers were not used to communicate in “user-friendly” and “non-technical” way with general public. They found it useless. The result is, that in general, researchers in Slovak Republic, despite the fact that they have internationally recognized results (e.g. this year nominations for Descartes Prize with researchers from the Slovak Academy of Sciences), are almost invisible in society and at the same time, they lack the sufficient communication skills and still did not see their necessary crucial role in dialog with society as one of their tasks - tasks, which are in their own interest. Therefore, specifically to the special circumstances in Slovakia, the implementation of the project will also act as a catalyst for communication of scientists with the society and researchers will be one the target group. The aim is to show Slovak researchers, that various stakeholders from society can be interested very much in their work and to like to interact with science. The main purpose of the project – Researcher’s Night 2007 that will take place on September, 28 is to bring relevant stakeholders, mainly large public and researchers together through innovative means of science communication with strong European spirit and dimension of the planned activities. The objectives of organizing this event are: improving the image of scientists in society, to show attractiveness of a researcher’s career, to show existence of science in our everyday lives, explain natural phenomena, raise awareness in science and technology, show researchers the growing interest of society in their work, show strong European and international spirit of being the researcher and establish the event as national tradition. Project will be implemented through following activities/events: awareness campaign, big science show Science Alive!, Phography Exhibition, Drawing Competition, Universities at Night, Author Reading, Sky at Night and Nature at Night.

Keywords: science,people,researcher,society,night,science communication,public,user-friendly,added value,policy-makers,interaction,youth,private sector,festivities,image,prestige,eu dimension
Memory loss in Alzheimer disease: underlying mechanisms and therapeutic targets (MEMOSAD)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Belgium,Germany,France,Ireland,Germany,Spain,Belgium,United Kingdom
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-01-01
End date: 2011-06-30
Duration (months): 42.0
Total project cost (EUR): 4023079.8
EU funding (EUR): 2998696.0
Participants: 10
Project status: CLOSED

MEMOSAD aims at defining the molecular mechanisms of Abeta- and Tau-induced synaptotoxicity and at developing disease-modifying therapeutics for the prevention of memory loss in Alzheimer disease (AD). Insoluble aggregates of the two proteins provide the pathological hallmarks of this incurable brain disorder. Early stage AD is characterized by a remarkably pure impairment of declarative memory and several lines of evidence suggest that this memory impairment is independent of the insoluble aggregates, does not require neuronal death and is caused by subtle and transient synaptic changes. The toxic Abeta and Tau species that cause synaptic dysfunction, their mechanism of toxicity and the link between both pathologies remain largely unknown, but recent data suggest that Abeta accumulation triggers Tau pathology. Consequently, primary neuronal cultures and animal models (C.elegans,zebrafish,mouse) will be employed to define the pathologic pathways leading from Abeta through Tau to synaptotoxicity. Initial experiments will investigate the effect of well-defined Abeta species on long term potentiation, synaptic morphology, gene expression, Tau phosphorylation/aggregation, axonal transport and behaviour. Similarly, we will investigate the functional consequences of Tau misfunction, aggregation, hyperphosphorylation and missorting in various cell culture systems (retinal ganglion cells, primary hippocampal neurons, organotypical slices) and animal models, especially with regard to intraneuronal trafficking and synaptic function. Once the toxic Abeta and Tau species are known and their mechanism of toxicity are defined, we will investigate how these pathways interact. Unravelling the pathologic pathways that lead from Abeta through Tau to synaptotoxicity and memory loss should reveal novel points for therapeutic intervention. Our aim is to deliver 3 or 4 validated therapeutic targets and at least 2 compounds with demonstrated therapeutic efficacy in mouse models of AD.

Keywords: alzheimer,abeta-mediated toxicity,tau-mediated toxicity,memory loss,therapeutic targets
Combined SIMS-SFM Instrument for the 3-Dimensional Chemical Analysis of Nanostructures (3D NANOCHEMISCOPE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Switzerland,Belgium,Belgium,Austria,Czechia,Netherlands,Germany
Call:  (FP7-NMP-2007-SME-1, 2007)
Start date: 2008-09-15
End date: 2013-01-14
Duration (months): 52.0
Total project cost (EUR): 5284260.2
EU funding (EUR): 4033699.0
Participants: 8
Project status: CLOSED

The objective of this project is to develop an innovative and novel combination of a new TOF-SIMS with substantially improved lateral resolution and sensitivity, combined with a new metrological high resolution SFM. The two techniques provide complementary information on nanoscale surface chemistry and surface morphology. In combination with a layer by layer removal of material using low energy sputtering, quantitatively measured by SFM, this combined ultra-high vacuum (UHV) instrument will be unique for the 3-dimensional chemical characterisation of nanostructured inorganic as well as organic materials with down to at least 10 nm lateral resolution and down to 1 nm depth resolution. Joint by a novel software for the calculation and display of 3-dimensional distributions of all chemical species, this leads to a totally new “3D NanoChemiscope”.

Keywords: sims,tof-sims,sfm,chemical analysis,depth profiling,3d analysis,organic nanostructures
Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine (APO-SYS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Sweden,France,Italy,Belgium,Germany,Switzerland,Denmark,France,Israel,Finland,Germany,Germany,Germany,Austria,Denmark,Ireland,Austria,France,Italy,Germany,France
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-02-01
End date: 2012-01-31
Duration (months): 48.0
Total project cost (EUR): 14780447.52
EU funding (EUR): 11000000.0
Participants: 24
Project status: CLOSED

A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.

Keywords: apoptosis,cell death,cancer,aids,systems biology
ASSESSMENT OF HEARING IN THE ELDERLY: AGING AND DEGENERATION - INTEGRATION THROUGH IMMEDIATE INTERVENTION (AHEAD III)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: Italy,Austria,Germany,Germany,Netherlands,Poland,Sweden,Switzerland,United Kingdom,Belgium,France,Germany,Hungary,Netherlands,Poland,Sweden,Cyprus,Spain
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-05-01
End date: 2011-10-31
Duration (months): 42.0
Total project cost (EUR): 1392131.92
EU funding (EUR): 1088190.0
Participants: 19
Project status: CLOSED

Hearing loss is one of the most common chronic health conditions in the elderly population with important implications for patient quality of life. The diminished ability to hear and to communicate is frustrating in and of itself, but the strong association of hearing loss with depression and functional decline adds further to the burden on individuals who are hearing impaired. Hearing loss can limit communications skills: not to hear means not to understand what is being said. Hence deafness does not produce compassion but do often produce a sense of irritation. Despite the prevalence and burden of hearing loss, hearing impairment is largely underdiagnosed in older persons and undertreated. The reason for this is that one of the most conspicuous signs of a hearing loss is that it cannot be seen! Actually, this is the reason why deafness does not receive the necessary attention. Too often, the public and still too many health care professionals underestimate the dramatic effects of deafness. Novel strategies should be explored to make screening and early intervention a feasible part of routine care. Project AHEAD III has been specifically designed to: - Provide evidence of the effects of hearing impairment in adults and particularly in the elderly - Analyse costs associated with the implementation of integrated large scale programmes of hearing screening and intervention in the elderly - Provide quality standards and minimum requirements for screening methods and related diagnostic techniques - Develop guidelines and recommendations on how to implement successful screening programmes to be tuned to the local, social, and economical conditions of a country.

Keywords: hearing,aging,screening technologies,audiological equipment
Predicting odor perception from odorant structure and neural activity in the olfactory system (ODORSPACE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Israel
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-07-31
Duration (months): 60.0
Total project cost (EUR): 1596000.0
EU funding (EUR): 1596000.0
Participants: 1
Project status: CLOSED

The rules linking odor perception to odorant structure are unknown. No scientist nor perfumer can predict an odor based on its molecular structure, or decipher a molecular structure based on its smell. It is this puzzle we aim to solve. In vision and audition coding was probed by linking critical physical stimulus dimensions (wavelength/frequency) to patterns of neural activity. But what are the critical physical dimensions in olfaction? Scientists have probed this by linking restricted physico-chemical aspects of the stimulus, e.g., carbon chain-length, to neural activity. However, the olfactory system did not evolve to decode carbon chain-length, but rather to encode the world around us as revealed in olfactory perception. With this in mind we developed a novel perception-based olfactory space with tangible olfactory axes, based on statistical dimension-reduction of perceptual estimates obtained from humans. In Aim 1 we will test the hypothesis that our generated space predicts olfactory perception in humans. In Aim 2 we will test the hypothesis that our generated space predicts odorant-induced neural activity in olfactory cortex (using fMRI) and epithelium (using novel methods for measurement from human neurons in vivo, methods then further explored as a potential diagnostic tool for Alzheimer's disease). In Aim 3 we will test the hypothesis that our generated space explains neural activity previously measured in the olfactory system across species. In Aim 4 we will use this framework to tune an artificial nose for medical diagnostics. In vision and audition scientists can probe the system within agreed dimensions (color/wavelength; pitch/frequency). Similarly, our proposal generates an olfactory space where one can systematically probe molecular receptor tuning-curves, cellular spatial and temporal coding schemes, as well as higher-order perception. In other words, we propose a common framework for olfaction research.

Keywords: sensory systems chemical senses olfaction
European Study to Establish Biomarkers of Human Ageing (MARK-AGE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Germany,Spain,Netherlands,Belgium,United Kingdom,Austria,Italy,Switzerland,Greece,Poland,Netherlands,Denmark,United Kingdom,Belgium,Germany,Germany,France,Finland,Austria,Romania
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-04-01
End date: 2013-09-30
Duration (months): 66.0
Total project cost (EUR): 15907409.6
EU funding (EUR): 11989327.0
Participants: 28
Project status: CLOSED

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Keywords: ageing,longevity,humans,progeroid,biomarkers,population,genetic,lifestyle,questionnaire,anthropometric,blood,serum,plasma,pbmc
Massive Neutrinos: Investigating their Theoretical Origin and Phenomenology (MANITOP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Germany
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2012-08-31
Duration (months): 48.0
Total project cost (EUR): 790800.0
EU funding (EUR): 790800.0
Participants: 1
Project status: CLOSED

The aim of the proposed project is to shed light on the theoretical origin of neutrino masses and to explore the phenomenological consequences of the model predictions and of possible mechanisms giving rise to neutrino mass. The results of many upcoming experiments in the neutrino sector and beyond will be a crucial discriminator for models and will have to be followed closely. Apart from the usual neutrino oscillation observables, there are more model-dependent implications of neutrino mass models, for instance lepton flavor violating decays and electric dipole moments in the charged lepton sector, or processes involving new particles at colliders such as the LHC. The connection to the baryon asymmetry of the Universe, to dark matter and to proton decay will also be studied. Phenomenology will also be focussed on: in particular, the implications of upcoming (precision) experiments on the neutrino mass and mixing parameters or the neutrino mass matrix will be investigated. The prospects of using high energy neutrino cosmic rays, neutrinoless double beta decay (including analogous processes) and new experimental ideas to probe the parameters of neutrino physics will also be explored.

Keywords: neutrino physics,astroparticle physics,lepton flavor violation