Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New speakers and use of Russian in the Northern Norway (NEW_WAY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

The NEW_WAY project will look at trajectories across the lifespan among Russian-speaking linguistic actors, and on the role of speaking/writing Russian in the political economy of Northern Norway around the Russian-Norwegian border. With the end of Cold War and implementation of more flexible border policies, Northern Norway, as other regions neighbouring with ex-USSR, got placed into the heart of geopolitics, global migration and sea trade, security and environmental crises. In the two decades after the Warsaw Pact dissolution, use and acquisition of Russian by different social actors, including speakers of other languages, has renewed its significance in the multilingual economy of the region. With this MSCA action, I would bring my competence on biographical research, knowledge of Russian and expertise on Russian-speaking migrant communities to complement the Norwegian research team. I wish to expand the biographical workshops methods with nexus analysis supervised by the world-renowned expert in nexus analysis. I will gain understanding of Northern borderland multilingual policies and practices in order to reveal deep-running social processes present and past (e.g. legal recognition, language investment and commodification, identity and community building etc.) with implications for social cohesion and peaceful neighbouring policy across other borderlands in Europe, as well as with potential for theory building and terminology creation. The project is expected to open ways to understanding the dynamics of decision-making that multilingual speakers undertake in investing into and building their individual language repertoires. Building from multi-sited ethnographic and biographical accounts, the project has a potential to construct a holistic perspective on multilingual practices and decision-making. The resulting picture goes beyond the sum of its elements and will inform critical rethinking of the concepts of community, diaspora, minority,majority and language.

Keywords: borderlands,globalization
Targeted Anti-Cancer Therapies (TACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Switzerland,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 3089569.68
EU funding (EUR): 3089569.68
Participants: 9
Project status: SIGNED

Antibody-Drug Conjugates (ADCs) are fast growing classes of oncology therapeutics. They consist in a highly potent cytotoxic drug connected via a linker to an antibody that is specifically targeting certain tumor markers. By combining the cytotoxicity of the drug and the targeting properties of the antibody, ADCs kill cancer cells whilst leaving the healthy cells unaffected, a marked improvement compared to classical chemotherapies. However, limitations still exist which could fuel the development of new generations of ADCs with improved therapeutical properties. Targeted Anti-Cancer Therapies (TACT) is an innovative, international, multidisciplinary training and research programme which thus aims to train 11 Early- Stage Researchers (ESRs) on the development of state-of-the-art anti-cancer therapeutics and equip them with transferable, future career-enhancing skills to create the next generation of experts in Europe. More specifically, TACT’s research programme will focus on key priorities for the conception of new and more potent generations of Protein-Drug Conjugates (PDCs): site-specific bioconjugation methods, more potent payloads, environment-specific cleavable linkers, more efficient protein-based targeting systems and new analytical tools for acute characterization. This will be achieved by exposing the ESRs to the leading intersectoral research scientists and laboratories in Europe who are active in this field. In doing so, TACT combines state-of-the-art research with excellent training in PDCs, one of the hot topics in cancer and targeted therapies.

Keywords: bioconjugation,antibodies,immunotherapy
The Physical Mechanics of Swimming Bacteria (PhyMeBa)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1999229.0
EU funding (EUR): 1999229.0
Participants: 1
Project status: CLOSED

Bacteria play a critical role in the life of higher organisms. Their behavior is constrained by the physical properties of their habitat: first and foremost, the presence of a surrounding fluid. Most bacteria are motile, and most motile bacteria swim in fluids using slender helical appendages called flagella rotated by specialized motors. While many bacteria have only one flagellum, most well-studied pathogenic bacteria possess multiple flagella. Why have some bacteria evolved to use many flagella when others survive with one? In order to answer this question, one needs to understand quantitatively how multiple flagella provide a fitness advantage to a cell exploring its environment. The principal difficulty in deriving rigorous models for swimming bacteria lies in the {nonlinear} nature of the underlying external physics, which involves nonlocal hydrodynamic interactions between flagella, short-range steric and electrostatic interactions, and elastic deformations of the flagella, which not only bend and twist but also undergo conformational changes. In this project, we will develop novel experimentally-testable theoretical modeling of the configurations and regimes relevant to swimming bacteria with multiple flagella with a focus on the mechanical forces at play. As a fundamental departure with past work, we will seek to exploit the slenderness and relative proximity of the flagella to incorporate all nonlocal hydrodynamic interactions between flagella analytically and to simplify the determination of elastic stresses. This will allow us, in turn, to determine precisely the distribution of flagellar forces and derive a predictive framework for the stochastic behavior of swimming cells. The project will provide first-principle understanding of the external forces at play in one of the most important processes in biology and will help answer a number of outstanding physical questions on the behavior of swimming bacteria and the interactions with their environment.

Keywords: mechanics of biological systems,soft matter in biology,locomotion of microorganisms
High energy lithium sulphur cells and batteries (HELIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Materials development and transformation
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Israel,Germany,Germany,Sweden,Finland,Slovenia,France,France,France,France,France,France,France
Call: Post-lithium ion batteries for electric automotive applications (H2020-NMP-GV-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 7974352.0
EU funding (EUR): 7974352.0
Participants: 17
Project status: CLOSED

Lithium sulphur batteries (LSB) are viable candidate for commercialisation among all post Li-ion battery technologies due to their high theoretical energy density and cost effectiveness. Despites many efforts, there are remaining issues that need to be solved and this will provide final direction of LSB technological development. Some of technological aspects, like development of host matrices, interactions of host matrix with polysulphides and interactions between sulphur and electrolyte have been successfully developed within Eurolis project. Open porosity of the cathode, interactions between host matrices and polysulphides and proper solvatation of polysulphides turned to be important for complete utilisation of sulphur, however with this approach didn’t result long term cycling. Additionally we showed that effective separation between electrodes enables stable cycling with excellent coulombic efficiency. The remaining issues are mainly connected with a stability of lithium anode during cycling, with engineering of complete cell and with questions about LSB cells implementation into commercial products (ageing, safety, recycling, battery packs). Instability of lithium metal in most of conventional electrolytes and formation of dendrites due to uneven distribution of lithium upon the deposition cause several difficulties. Safety problems connected with dendrites and low coulombic efficiency with a constant increase of inner resistance due to electrolyte degradation represent main technological challenges. From this point of view, stabilisation of lithium metal will have an impact on safety issues. Stabilised interface layer is important from view of engineering of cathode composite and separator porosity since this is important parameter for electrolyte accommodation and volume expansion adjustment. Finally the mechanism of LSB ageing can determine the practical applicability of LSB in different applications.

Keywords: energy storage,li s batteries,automotive application,prototype cells and battery packs,safety,recycling,modelling
Ubiquitous Quantum Communications (QuantCom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 2496372.0
EU funding (EUR): 2496372.0
Participants: 1
Project status: SIGNED

''It is difficult to make predictions, especially about the future'' - Mark Twain. Yet, Gordon Moore's predictions - known as Moore's Law - made in 1965 remained valid for half a century! As a result, semi-conductor technology is approaching nano-scale integration and on this journey to quantum futures the traveller enters the world of quantum physics, where many of the phenomena are rather different from those of classical physics. This proposal contributes to the 'quantum jig-saw puzzle', with special emphasis on the enabling techniques of ubiquitous quantum communications, potentially leading to job- and wealth-creation on a similar scale to the economic benefits of flawless classic wireless communications. My ultimate goal as a telecommunications researcher is to build bridges across the exciting fields of quantum physics, mathematics, computer science and hardware aspects of quantum communications. Specifically, the three Key Challenges of Work-Packages 1-3 on the new concept of Pareto-optimum error control, secret key-distribution, network coding and entanglement distribution will lead to creating stepping-stones for the Grand Challenge of Work-Package 4, dedicated to the support of quantum-communications for aircraft 'above the clouds'. Methodology: theoretical performance bounds will be established based on the hitherto unexplored Pareto-optimum quantum design philosophy using multi-component optimization. Explicitly, the Pareto-front of optimal solutions will be found off-line, where none of the conflicting parameters, such as the bit-error ratio, transmit power, delay and implementation complexity can be improved without degrading some of the others. A suite of new soft-decision aided components will be conceived by invoking code-specific quantum syndrome decoders to be designed for iterative soft-information exchange without perturbing the fragile quantum states. Finally, quantum-communications solutions will be created for drones and planes.

Keywords: quantum communications,quantum signal processing,quantum codes,quantum network codes,quantum routing,entanglement distribution,quantum key distribution,aircraft communications,drones
Innovative system for Bioinspired Atmospheric Water Generation without Input Energy (DAPHNE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Türkiye
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

After obtaining the Seal of Excellence (attached) from the EU on the previous cut-off day (ESR Score: 13,63), this is an improved version of the proposal. The Earth’s water supply is – paradoxically – both abundant and scarce. The planet has more than 1,400M km3 of water, of which 97.25% in the form of oceans and seas. However, freshwater represents just 2.75% of that volume or 39M km3. Already today, nearly half of the EU countries suffer from water scarcity and thereof foremost the farmers (and so agriculture sector), accounting for 80% of freshwater demand. Against this background BIGEKA has developed an innovative, energy-efficient and sustainable technology to generate atmospheric water (DAPHNE) cost-efficiently (by using special designed and produced nano-engineered materials that offer great potential for water innovations) and environmentally-friendly (by minimizing the groundwater need in agriculture and other negative externalities, including salinity and stream depletion) DAPHNE uses nanostructured surfaces to produce 300% more water than any other system in the market at 8000% lower weight (0.1 kg instead of 80 kg) which brings efficiency, feasibility and mobility. The worldwide market for industrial and domestic water equipment is worth an estimated EUR 918.9M in 2015. With growing concern in water availability, it is expected to grow at a compound annual growth rate of 37.4% to 2022 and market value of water withdrawal market rises is expected to reach EUR 9.3B. BIGEKA is delighted to be pioneer of this innovative project and the introduction of DAPHNE into the market will have a positive impact on: i) the economy of farmers (our customers), by allowing them to use water at lower costs ii) the environment, and iii) BIGEKA’s economic growth. The growth potential of DAPHNE is expected to result in about €28M annual turnover, 70 new employment positions, 7.54% market seize, 47% return on investment, and €23.5M cumulative profit at the end of 2023.

Keywords: atmospheric water generation,freshwater production,nature inspired,biomimicry,water efficiency,zero energy
Unraveling the consequences of early cerebellothalamic dysfunction and its role in autism spectrum disorder symptoms (UNCERTHAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Cerebellar abnormalities are consistently reported in autism spectrum disorder patients, however the cerebellar contribution in the etiology of this pathophysiology remains poorly understood. It has been proposed that the cerebellum may drive the maturation and functionality of cortical high-order structures involved in the core symptoms of autism. However, the mechanisms by which the cerebellum could control these processes remain to be determined. The neural circuits linking cerebellum with the cerebral cortex via thalamic relay stations are the anatomical scaffolds underlying the cerebellar cognition. Recent data have shown that the thalamus plays a key role in the reorganization of cortical areas after early sensory deprivation. Therefore, during early development, abnormal cerebellar inputs to the thalamus may contribute to cortical dysfunctions that could lead in high-order deficits. However, despite being autism a neurodevelopmental disorder, any study has addressed the analysis of cerebello-thalamo-cortical circuits from a developmental perspective. The present project (UNCERTHAIN) offers an exceptional opportunity to shed light onto this issue as a result of the unique combination of approaches. Accordingly, we will use an experimental model that offers the possibility to embryonically alter the cerebellothalamic connectivity and thus, study the mechanisms underlying the events that influence the normal development and functioning of cortical circuits. Hence, we will adopt both multidisciplinary and innovative approaches to characterize the thalamocortical network in presence of a disrupted cerebellar input, the functional consequences and its relationship with autistic-like behaviors. The successful execution of this high-risk, high-impact research will provide insights on how the cerebellum governs the development of cortical areas essential for social and cognitive behaviors and its involvement in high-order neurodevelopmental disorders such as autism.

Keywords: cerebellum,thalamus,autism
Solving large systems of polynomial equations by using multi-linear algebra tools (TENSOROOTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-03-01
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: TERMINATED

The modelling of real-life nonlinear processes is commonly done via local linearization, i.e., by fitting linear models to small ranges of the process. Linearization is, however, quite limited in range and model properties. A foundational step is currently being made by moving from linear to multi-linear or polynomial models to capture more general features of a nonlinear process over larger ranges. A second important development is Big Data: nowadays we often encounter high-dimensional datasets with multiple `independent’ modes of variation. This increases the numbers of equations and variables and the degrees of the polynomials in the multi-linear models that are required. Big Data research is a key priority in the EU Horizon 2020 Work Programme. This proposal joins both the cutting edge multi-linear and Big Data developments and as a next step aims to develop new robust and efficient numerical methods to solve large polynomial systems. Polynomial equations arise naturally in a large number of diverse fields such as signal processing, robotics, coding theory, optimization, bioinformatics, computer vision, game theory, statistics, machine learning, and systems and control theory. In many applications the coefficients of the polynomials are noisy (i.e., computed from measured data). Currently, solving polynomial equations is commonly done via ‘symbolic algebra’ tools, but these are not suitable for equations with noisy coefficients. However, the rediscovered work of Sylvester and Macaulay puts the problem in a linear algebra setting and well-known numerical linear algebra tools can be used. This project will go beyond this and uses new highly efficient multi-linear algebra tools in the field of tensor decompositions. The latter are higher-order generalizations of the matrix singular valued decomposition. The project combines polynomial algebra, numerical linear algebra, and multi-linear algebra, and will have large impact on a large number of applications.

Keywords: polynomial algebra,multi linear algebra,numerical linear algebra,tensor decompositions,signal processing,systems theory
RADIOGENOMICS: Finding Genetic Functional Variants Through Fine Mapping (RADIOGENFF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

“Radiogenomics” is the study of the genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity phenotypes in local tissues. To increase the very limited power of each independent study, the three groups are collaborating on a meta-analysis of harmonised toxicity phenotypes (nocturia, urinary frequency, decreased stream and proctitis) and have identified several promising new loci. The proposed activity at the Centre for Cancer Genetic Epidemiology will be fine-scale mapping of these loci identified with the aim of identifying the genetic variants directly responsible for these toxicity phenotypes. The objectives of the proposed research are: 1. For the Researcher to learn advanced genetic epidemiological and fine-mapping skills by participating in team-based analysis of incoming massive, “OncoArray” datasets – which will be analysed at the host institution; 2. Identify and validate additional novel genetic radiation toxicity loci through analysis of specific radiotoxicity SNP-sets on the “Oncoarray” and through additional GWAS meta-analysis; 3. Apply high-level skills, gained in objective 1, to the fine scale mapping of radiation toxicity loci with the aim of to identifying the top genetic causal candidate variants for radiation toxicity; 4. Carry out bioinformatic functional analysis of the top causal candidates to both narrow the candidate list further, and gain understanding of the molecular patho-physiology and genetic mechanisms that mediate the development of radiation-induced toxicity. Knowledge of these will constitute a further step in identifying genetically at-risk groups likely to benefit from personalized radiotherapy.

Keywords: fine mapping,gwas,stepwise logistic regression,radiotherapy,prostate cancer