Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Keeping nodules in check: Interplay of rhizobial and host factors controlling nodule morphogenesis and identity in legume plants. (Nod2Root)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Symbiotic nitrogen fixation by rhizobia takes place in specialized organs of legume host plants, the root nodules. While rather deep molecular insights into plant-rhizobia recognition, early nodule organogenesis, regulation of nodulation and nitrogen fixation are available, much less is known about how nodule integrity is maintained and the origin of the underlying morphogenetic program. Recently, NOOT BOP COCH LIKE (NBCL) genes of Medicago truncatula and Pisum sativum were found to ensure nodule integrity by repressing ectopic root formation (applicant's former project). Interestingly, soybean nodules elicited by a Bradyrhizobium diazoefficiens mutant lacking the general stress response sigma factor σEcfG also formed ectopic roots (host's project), pointing to a bacteria-plant signalling system that is crucial for nodule persistence and integrity. Here, we propose to decipher the molecular determinants that maintain determinate nodule identity using the B. diazoefficiens – soybean model. We will combine plant molecular genetics, cell biology with transcriptomics and metabolomics to unravel cells, genes and metabolic networks that contribute to the checkpoint system ensuring nodule integrity. In work package 1 (WP1), the role of three soybean NBCL orthologs will be unravelled. In WP2, the nodule-to-root conversion characteristic for B. diazoefficiens ΔecfG mutants will be studied at the cellular level using root tip-specific reporter fusions. In WP3, a combination of metabolomics and transcriptomics will be applied to identify metabolites and gene networks involved in the nodule-to-root conversion elicited by ΔecfG and nbcl mutants. Altogether, results of this project will provide insight into determinants and mechanisms used by the economically important group of soybean plants to maintain the integrity of specialized, root-derived organs, an aspect that is relevant also in the light of ongoing attempts to engineer non-legumes into rhizobial hosts.

Keywords: glycine max soybean,bradyrhizobium diazoefficiens,symbiosis,noot,ecfg,sigma factor,homeosis,nodule organogenesis and development
MechANIsms and actors of Feasible Energy Transitions (MANIFEST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway,Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1499408.0
EU funding (EUR): 1424408.0
Participants: 2
Project status: SIGNED

The technologies needed to decarbonize the electricity system are already commercially available. There are mathematical models of how these technologies can be deployed sufficiently fast and at a large enough scale to displace fossil fuels to meet climate targets. Yet there is no scientific method to evaluate whether these scenarios are feasible given the real world’s socio-political constraints. MANIFEST develops a new scientific understanding of socio-political feasibility of climate change mitigation that takes into account the context, actors and change over time. Theoretically, MANIFEST combines a definition of socio-political feasibility from political philosophy with the concept of causal mechanisms of energy transitions. Thus, I shift the thinking about the feasibility of climate change mitigation from its current focus on barriers and enablers to a dynamic and context sensitive view with space for actors and agency. Empirically, I focus on transitions in electricity supply including the expansion of low-carbon electricity and coal phase-out. I explore three areas which are critical for the feasibility of decarbonisation of electricity: (i) the role and capacities of international suppliers of electricity technologies, (ii) the competition between electricity technologies at the early stages of their introduction in emerging economies, and (iii) factors shaping the growth of low-carbon technologies and under what conditions they substitute carbon-intensive ones. Methodologically, I develop a new approach to assess the feasibility of climate solutions by constructing dynamic feasibility spaces which are a function of paths, contexts and actors. I test this approach by analysing national low-carbon electricity targets to determine whether states plan to accelerate decarbonisation beyond the current feasibility frontier. This dynamic feasibility space is a breakthrough in assessing the feasibility of national and global climate change mitigation solutions.

Keywords: energy transitions,climate change mitigation,low carbon scenarios,renewables
Boosting the Rare Disease research and innovation capacity of the Izmir Biomedicine and Genome Center (RareBoost)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Türkiye
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 2499125.0
EU funding (EUR): 2499125.0
Participants: 1
Project status: SIGNED

Although diseases afflicting less than 1 person in 2000 are defined as rare diseases, the approx. 6000 different rare diseases together cause, nonetheless, a major burden on human wellbeing and the health systems. Over 90% of all rare diseases are currently without approved treatment and approx. 80% of them are genetic in origin. However, the research on rare diseases and the development of new diagnostic and therapeutic approaches is often hampered by limited resources, including patient material and biological models. The frequency of rare diseases increases in populations with a high frequency of consanguineous marriages. Within ERA, Turkey has the highest rate of consanguineous marriages and, consequently, rare diseases are about twice as prevalent in Turkey than in other ERA countries. The aim of this RareBoost project is to attract an internationally recognized rare disease expert (ERA Chair holder) to the Izmir Biomedicine and Genome Center (IBG), where s/he will lead and direct the new Unit for Rare Diseases and guide its development towards an internationally recognized research facility for rare diseases. IBG is perfectly suited for this development, as it is (i) the largest and best-equipped public biomedical research institute in Turkey, (ii) the only nationally recognized Centre of Excellence in the biomedical sciences, and (iii) already made significant steps towards research excellence. This RareBoost project will greatly facilitate IBG’s aim to become a leading basic and translational research centre for rare diseases. Furthermore, by becoming an internationally recognized hub for rare disease research, IBG will act as a guide for the Turkish R&D sector, will facilitate ERA homogeneity and will support the well-being of rare disease patients. Therefore, RareBoost will greatly boost IBG’s ability to increase ERA-wide cohesion, to support innovation for diagnostics and therapies of certain rare diseases, and to reduce patient suffering.

Keywords: gene regulation,genomics,epigenetics,mouse genetics,transcription factors,chromatin structure and function,protein complexes
Network of Science with and for Society National Contact Points 2019-2020 (SiS.net 3)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Egypt,Israel,Germany,Spain,Italy,Iceland,Cyprus,Belgium,Croatia,Greece,Poland,France,Czechia,Portugal
Call: Fostering transnational cooperation between National Contact Points (NCP) in the area of Science with and for Society: follow-up project (H2020-IBA-SWAFS-NCP-2018, 2018)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 17
Project status: CLOSED

Science with and for Society has a vital role to play in bringing together a wide range of stakeholders in order to build capacities and develop innovative ways to connect science to society through Responsible Research and Innovation measures. This demands that the Science with and for Society National Contact Points (NCPs) are able to orientate in the wide area of policy behind the programme, its topics and research areas as well as in Horizon 2020 rules and regulations and in addition, they need to have extensive knowledge of the different groups of stakeholders, in order to be able to fulfil their job. The proposal focuses on identifying and sharing good practices and raising the standard of proposals by organising joint activities of NCPs. The consortium ensures a balance of experienced NCPs and newcomers in order to build on knowledge and enhance skills and competences of all NCPs within the programme. This will result in more consistent and improved NCP services which will enhance participation in Science with and for Society calls.

Keywords: horizon 2020,science with and for society,national contact points,responsible research and,innovation,ethics,open access,gender,governance,education,communication
Making Sense of Games: A Methodology for Humanistic Game Analysis (MSG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Denmark
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-04-30
Duration (months): 66.0
Total project cost (EUR): 2006905.94
EU funding (EUR): 2006905.94
Participants: 1
Project status: CLOSED

Making Sense of Games (MSG) will build a methodology for the humanistic study of games, and develop a theory of how ludic meaning is produced. Following the pervasive, global growth of video gaming culture and the games industry, the multi-disciplinary field of game studies has grown exponentially in the last 15 years, with numerous new journals, conferences, university programs and research departments. However, still lacking at this ‘adolescent’ stage of the field’s development are game-specific methods and theoretical foundations necessary to train researchers and build curricula. In aesthetic games research there is not yet any widely accepted methodology for game analysis, and there has not yet been any large-scale, long-term attempt to produce a theoretical platform that can support and advance the field. MSG aims to fill this gap by combining fundamental hermeneutic approaches (semiotics, reception theory, reader response, theories of representation, narrative theory) with recent theories of ludic structure (game ontology) into a hermeneutic theory of game meaning, which can be used as a set of tools and concepts for game analysis and criticism. MSG will be a triple first for aesthetic game research: a five-year research program, a hermeneutic theory of games, and a team-based effort to build an interdisciplinary methodology. The results from MSG will speak to many of the current public concerns and debates about games, such as gamer culture, games’ cultural and artistic status, the representation of minorities, misogyny, violence and even addiction. MSG will demonstrate the strong usefulness of humanistic approaches not only to game studies itself, but also to the 21st century’s most vibrant new cultural sector. It will also provide other aesthetic fields (literary studies, film studies, art history) with theoretical models, critical insights, and a rich empirical material for comparative exploration.

Keywords: interdisciplinary humanistic game studies,game hermeneutics,game aesthetics,game analysis methods
LETHE (λήθη) – A personalized prediction and intervention model for early detection and reduction of risk factors causing dementia, based on AI and distributed Machine Learning (LETHE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Italy,Italy,Austria,Cyprus,Belgium,Sweden,Finland,Greece,Finland,Netherlands,Netherlands,Luxembourg
Call: Personalised early risk prediction, prevention and intervention based on Artificial Intelligence and Big Data technologies (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 5999888.74
EU funding (EUR): 5999888.74
Participants: 15
Project status: SIGNED

As the world's population increases in age, the number of people living with dementia grows. Dementia has long been considered to be neither preventable nor treatable, but while the underlying illnesses are not curable, today we know that the disease course might be modifiable with good preventive interventions at an early time point. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed a positive effect after a 2-year intervention targeting several lifestyles and vascular risk factors simultaneously. LETHE will go beyond and provide a data-driven risk factor prediction model for older individuals at risk of cognitive decline building upon big data analysis of cross-sectional observational and longitudinal intervention datasets from 4 clinical centers in Europe including the 11- years analysis of FINGER. LETHE will establish novel digital biomarkers, for early detection of risk factors, based on unobtrusive ICT-based passive and active monitoring. The aim is to establish a digital-enabled intervention for cognitive decline prevention based on the evolution of a successful protocol (FINGER) evolving into an ICT based preventive lifestyle intervention through individualized profiling, personalized recommendations, feedback and support (FINGER 2.0), well targeted on a population stratified by cost-effective biological biomarkers. The LETHE solution will be tested in a feasibility study validating the achieved improvements. A successful LETHE project could lead to a more personalized risk factor prevention for persons with beginning cognitive decline, thereby empowering people to an active and healthy lifestyle. Expansions of prevention trials on large scale by an automatized roll out of a multimodal intervention approach, reaching out to large populations, could save future costs on expensive traditional interventions and confer benefits for the wider society.

Keywords: data driven prediction model,cognitive decline,dementia risk factors,lifestyle intervention
Hydrophobic metal-organic adsorbents to decontaminate water from Per- and polyfluoroalkyl substances (HECTOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Aligned with the United Nations SDGs 3 and 6: ‘Good Health and Well-being’ and ‘Clean Water and Sanitation’ respectively, and Stockholm convention regulations on restricted contaminants in drinking water, removal of Per- and polyfluoroalkyl substances (PFAS) is a global challenge of twenty-first century. Traditional PFAS decontamination involving adsorption on granular activated carbon (GAC) as state-of-the-art method suffers from slow kinetics, interference during adsorption and high energy footprint of regeneration. These pitfalls foster the search for alternative energy-efficient adsorbents that rely upon regenerable adsorption. Development of underexplored as well as new generations of hydrophobic metal-organic frameworks (HMOFs) and derived hybrid composites have the potential to provide a better solution for PFAS removal. Incisive structure-function insights on PFAS adsorbent design will lead to benchmark PFAS adsorbents a priori, stemming from porous and modularly built HMOFs. Optimization of operating conditions/adsorbent columns design will synergistically maximize PFAS removal efficiencies (quantitatively >2-3 times over GAC) in order to decrypt the key structural chemistry-PFAS adsorption relationships in three generations of HMOFs to enable them emerge as benchmark materials. Whereas my current research theme focuses upon ‘Physical chemistry and electrochemistry of metal-organic solids and surfaces’, I will complement my expertise by training through research mainly on a) hydrophobic MOF composites with surface fabrication and/or defect chemistry, b) custom-designed PFAS decontamination-friendly columns, c) simulation tools to map PFAS-adsorbent interactions during my MSCA IF at TU Munich. Long-term career goal set at being a world leader in Purification Chemistry, this fellowship will be decisive for me to achieve academic independence, aided by research career start-up grants leading to tenure track professorships within EU.
Twin-model based virtual manufacturing for machine tool-process simulation and control (TWIN-CONTROL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Spain,Spain,Belgium,France,France,France,United Kingdom
Call: Integrated design and management of production machinery and processes (H2020-FoF-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 5600241.25
EU funding (EUR): 5600241.0
Participants: 11
Project status: CLOSED

Europe is the world’s largest manufacturer of machine tools but this position is threatened due to the emergence of Asian countries. However, Europe has world-class capabilities in the manufacture of high-value parts for such competitive sectors like aerospace & automotive and this has led to the creation of a high-technology, high-skill industry. European machine tool builders, part manufacturers and other agents have to work together to increase the competitiveness of European manufacturing industry. Simulation tools are currently a key complement to European machine tool industry expertise but new integrated approaches are needed. The main objective of Twin-Control is the development of a simulation and control system that integrates the different aspects that affect machine tool and machining performance. This holistic approach will allow a better estimation of machining performance than single featured simulation packages, including lifecycle concepts like energy consumption and end-life of components. This integrated concept will also enhance the necessary collaboration between machine tool builders and part manufacturers. The specific industrial objectives are: • Getting machines that work as designed faster (10% reduction) • Getting production processes that work as planned faster (20% reduction) • To get a first-time-right part manufacturing (75%) • To increase production time trough model-based control (increase of 1-2%) • To reduce energy consumption (25-50%) • Improve machine reliability and increase machine up-time due to a proactive maintenance (2-4.5%) All these will contribute to reduce machine tool life cycle costs (15 %) with a reduction of O&M costs in the range of 25%. The project considers the validation and demonstrator in real production scenarios in aerospace and automotive industries. Added to this, 3 demonstrators will be set-up in three pilot lines for spreading results beyond the project end

Keywords: machine tool,simulation,model based control,proactive maintenance,energy efficiency,fleet based knowledge
Understading the Maize Epigenome and its Role in Development (EPIMAIZE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 178603.2
EU funding (EUR): 178603.2
Participants: 2
Project status: CLOSED

Phenotypes are largely determined by genetic factors. However, a given genotype can give rise to very distinct phenotypes, as exemplified by the diversity of cell types in multicellular organisms. This phenotypic plasticity results from epigenetic changes; that is, reversible modifications to the DNA molecule and its associated proteins that modulate gene expression patterns. Epigenetic changes are critical to the establishment of developmental programs, but also to adjust transcription in response to the environment. The latter is particularly important for plant adaptation: owing to a sessile (immobile) lifestyle, plants cannot run away from adversity, and thus adapt to their environment by tuning gene expression in response to changing conditions. Most epigenetic information is erased from one generation to the next, so that new organisms start their life cycle with a “fresh” potential. However, there are instances in nature of heritable epigenetic marks that can be transmitted to the next generation. Thus, owing to their role in shaping gene expression, and the potential for heritable changes, epigenetic factors are of great interest for plant breeders, in their quest for adaptable, high yielding phenotypes. Most of our current understanding of epigenetic processes in plants has been developed in Arabidopsis, a key model system. However, the Arabidopsis epigenome is rather idiosyncratic, and this knowledge might translate poorly to crops. Here, we will use an interdisciplinary approach combining original genetic materials and bioinformatics to analyze epigenetic regulatory pathways in maize, with a focus on reproductive development. Maize is an important model plant, with a large and dynamic epigenome much more typical of crops. It is also a crop of great economic importance. Better understanding the epigenome of maize will open the door to the manipulation of key agronomic traits, including reproductive development, which is under strong epigenetic influence.

Keywords: maize,reproductive biology,apomixis