Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synergistic Nano-Therapeutic Approach for Psoriasis: Targeting TNF-α and IL-17 Pathways via Transdermal Delivery (SKINNOVATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-15
End date: 2027-10-14
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Psoriasis, affecting 2-3% of the global population and 20 million individuals in Europe, poses significant challenges in treatment efficacy and patient adherence to current therapies. Addressing these challenges, this project proposes an innovative therapeutic strategy by integrating Etanercept (ETR), a TNF-α inhibitor, with small interfering RNA (siRNA) targeting IL-17A, facilitated through a novel transdermal delivery method. The project aims to develop and optimize hybrid lipid-polymer nanoparticles (LPNs) for co-delivering ETR and siRNA. These LPNs will be incorporated into microneedles (MNs) composed of biocompatible polymers, pectin, and polycaprolactone (PCL). This dual delivery approach leverages LPNs' controlled release properties and MNs' enhanced skin permeability to target multiple pathogenic pathways involved in psoriasis synergistically. Specific objectives include optimizing LPN formulation, evaluating efficacy in vitro, characterizing the MN system for skin penetration, and assessing performance in ex vivo psoriasis models, guided by ethical principles (3Rs: Replacement, Reduction, and Refinement). Expected outcomes encompass improved treatment efficacy, reduced adverse effects, and enhanced patient adherence, thereby advancing psoriasis management. Furthermore, this project seeks to catalyze interdisciplinary collaborations and propel the development of novel therapeutic strategies, contributing to scientific innovation and healthcare advancement.

Keywords: biomedical engineering drug delivery nanotechnology sirna lipid polymer nanoparticles microneedles transdermal delivery
Safety and Awareness For Everyone in Virtual Reality (SAFE-VR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Social virtual reality (VR) is rapidly transforming how people interact. It creates immersive virtual spaces for social engagement, such as leisure activities, remote work, training and other social events. However, the rise of these platforms has brought significant challenges to user safety. The SAFE-VR (Safety and Awareness For Everyone in Virtual Reality) project aims to develop a comprehensive system to mitigate harassment in social VR by automatically detecting it and providing immediate user support. The first objective will be achieved by analyzing group movement patterns with machine learning methods to detect harassment in social VR. The second objective consists of two parts: 1) dynamic, context-aware personal boundaries that adjust based on the nature of interactions and user preferences, and 2) an intuitive reporting system that automatically captures relevant data when harassment is detected or a report is initiated, easing the process for users. These solutions will be integrated and delivered through the open-source SAFE-VR platform. Perceptual studies will be conducted to evaluate the platform’s efficiency, effectiveness, and its impact on user behavior and sense of safety. An industrial secondment with Virtual Bodyworks, a company specializing in VR for behavioral change in corporate and rehabilitation settings, will provide opportunities to explore real customer needs and tailor the SAFE-VR platform for their commercial VR applications. By delivering adaptable safety mechanisms, this project has the potential to influence future social VR safety standards and benefit developers, users, and policymakers alike.

Keywords: virtual humans,computer animation,perception
Designing Democracy on ´Mars´ and ´Earth´: Exploring Citizens´ Democratic Preferences in a Deliberative and Co-Creative Design (DDME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2056149.0
EU funding (EUR): 2056149.0
Participants: 1
Project status: SIGNED

DDME sets up a bottom-up, co-creative and deliberative design to obtain a deeper understanding of citizens´ democratic preferences in two Western (Germany and United States) and one non-Western country (India). Democratic preferences contain procedural preferences for different governance modes – such as participatory, delegative, consensual or majoritarian forms of democratic governance – as well as preferences for democratic goals and values - such as equality or social justice. Based on input and feedback from democratic theorists, DDME explores how citizens imagine “ideal” democracy (on “Mars”) and mend “real” democracy (i.e., how they would reform the political systems they live in (on “Earth”)) when they had the chance to deliberate, i.e. to ´weigh´ reasons regarding the pros and cons of the various conceptions and schemes of democracy in a dialogical setting with their fellow citizens. The deliberative field experiments will comprise 600-900 representative or maximally diverse citizens and will be run on a “hybrid” platform combining synchronous and asynchronous modes of interaction. DDME analyses which factors drive different democratic preferences of citizens in the three different countries and which principles and arguments play a role in the opinion and preference formation of citizens´ democratic preferences (with a specific eye on opinion and preference change). The project is the first to delegate democratic designing to citizens adopting a systematic and global approach where citizens together with democratic theorists think through advanced theoretical inputs and think creatively about optimal democratic designs.

Keywords: deliberation,democratic theory,public opinion,citizen perspectives
Human Rights in the Menstrual Movement (PERIODS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999736.0
EU funding (EUR): 1999736.0
Participants: 1
Project status: SIGNED

The period emoji, the year of the period, and an Oscar-winning documentary—with menstruation gaining attention at all levels, PERIODS explores the promises, pitfalls, and renewed potential of human rights in the menstrual movement. While research, policy, and practice on menstruation to date largely focus on tangible, material needs and risk leaving menstrual stigma and its role in perpetuating gender injustices intact, PERIODS recognizes that menstrual stigma and unmet menstrual needs have profound effects on the human rights to health, bodily integrity, education, work, and participation in social, cultural, and public life. The project centers the social practice of human rights in the menstrual movement by drawing on the articulations of lived experiences of people who menstruate and perspectives of movement leaders. It will examine if social movements reframe how human rights related to menstruation are understood and if so, how they move beyond the dominant reductionist framings in favor of a holistic, inclusive, and expansive conceptualization of human rights. The project combines empirical research using in-depth interviews, focus groups, qualitative surveys, and document analysis with conceptual work grounded in human rights. Theoretically, the project is rooted in the critical engagement with human rights and a re-envisioning of human rights ‘from below'. It considers the practice of human rights in the menstrual movement as constitutive of what matters for the realization and conceptualization of human rights. By connecting global and local struggles and movements in the global South and North, PERIODS will not only develop a thicker, more nuanced understanding of human rights in the menstrual movement, but also has the potential to generate significant empirical insights from a young, translocal, global South-driven movement for the reconceptualization of human rights based on social practice.

Keywords: menstruation menstrual health gender justice
Eastern Central Europe’s earliest shelters (HOME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1997921.0
EU funding (EUR): 1997921.0
Participants: 1
Project status: SIGNED

From penthouses to igloos, homes are a cornerstone of human society, deeply entrenched in our evolutionary past. Their staggering array of architecture simultaneously shape and reflect our sociocultural traditions, structure our local economies, and have enabled us to inhabit all four corners of the earth. Yet surprisingly little is known about their earliest forms—Palaeolithic shelters. This is because no systematic attempts have been made to target their early archaeological signatures. HOME will search for a diversity of Palaeolithic shelters during the Late Pleistocene through informed systematic surveys and excavations of archaeological sites in East-Central Europe, a place where early mammoth bone structures suggest precocious shelters, but where the record remains inconclusive. This project’s goal is to uncover and assess a variety of Palaeolithic shelters with the aim to understand the diverse ways that humans lived and survived in some of the coldest, harshest climates. The objectives are to: (1) Recognize the factors that influence the location and design of forager shelters through a goal-directed study of ethnographic documentation. (2) Develop new geophysical methods to identify open-air shelter residues in large-scale archaeological surveys. (3) Determine how one of the earliest unambiguous built structures, a mammoth bone structure, was used with the latest techniques in archaeological science. (4) Compare and contrast how these open-air shelters relate to a regional cave occupation through targeted excavations. The results will elucidate how our ancestors adapted to past climate change and expanded into new biomes, ultimately leading to our ubiquitous population of the earth. In addition to its significance to archaeology and anthropology, the outcomes have implications for theories of culture, evolution and human resilience by helping us understand the physical building blocks of early societies.

Keywords: geoarchaeology,environmental archaeology,excavation
Hop-On QUantum enhANced phoTonic Integrated sensors For metrologY (Hop-On QUANTIFY)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Croatia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 25.0
Total project cost (EUR): 599843.75
EU funding (EUR): 599843.75
Participants: 2
Project status: CLOSED

Atomic Quantum Memories (QMs) have been primarily exploited for applications requiring the on-demand storage and retrieval of light pulses, such as long- distance quantum communication, synchronization of single-photon sources, and quantum computers by enabling efficient quantum data transfer and entanglement distribution, extending communication distances, and increasing fidelity for extended periods compared to classical methods or direct transmission without memory-assisted buffering. In this scenario, a new and still largely unexplored frontier has emerged: QMs can serve as a key tool for advancing quantum imaging and sensing. With Hop-On QUANTIFY, we will contribute to this effort by both developing miniaturized QM with state-of-the art performance and by conducting a study aimed at unlocking and revealing the potential of QMs to enhance the performance of quantum sensors, particularly those being developed within the QUANTIFY project. To do this, we will replace the standard vapor cell used in memory operating @Institute of Physics in Zagreb with miniaturized MEMS cells and, we will test the same 780 nm photonic integrated circuit (PIC) laser developed for the QUANTIFY project, optimized for the excitation of the first resonance line in the Rb atoms. Our proposal represents a crucial advancement in addressing the challenge of applying MEMS cell and PIC lasers to real-world applications testing their performance for the QMs application. This pioneering application marks a significant advancement, leveraging cutting-edge PIC technology for on-chip quantum memory development. Finally, we will undertake a detailed study to assess the potential of QMs in enhancing the performance of quantum sensors by identifying performance gaps and assessing whether QMs can address these limitations, and by evaluating the potential of squeezed light sources in enhancing QM performance. Metrology protocols to ensure the traceability of QMs to SI will be also proposed.

Keywords: quantum memories,quantum enhanced sensors,metrology,key enabling technologies,nanofabrication,quantum maesurements,chip scale devices
Exploring the impact of Time-Restricted Eating and Exercise interventions on Gut microbiome of patients with hepatic steatosis and obesity – TREEGut (TREEGut)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

TREEGut investigates the role of the gut microbiome in reducing hepatic fat and improving cardiometabolic health through a novel intervention combining time-restricted eating (TRE) and exercise in individuals with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). Innovative and easy-to-implement interventions are necessary to alleviate the burden on healthcare systems and improve patient health affected by obesity-related diseases. The gut microbiome, implicated in disease pathogenesis, presents a promising therapeutic target. TRE, an intermittent fasting method that is effective and easy to implement, shows potential benefits that could be enhanced when combined with exercise. However, the extent of the microbiome's influence on these interventions remains unclear. TREEGut aims to elucidate how the benefits of TRE and exercise on hepatic fat and cardiometabolic health are mediated by changes in the gut microbiome, identifying specific microbial signatures and microorganisms that could inform personalized treatments. Under the supervision of Prof. Jonatan Ruiz at the University of Granada, TREEGut will integrate clinical assessments, gut microbiome analyses, and lifestyle interventions across human and mouse models, using advanced genomic technologies. A key phase of the project includes a secondment at Leiden University Medical Center (LUMC) supervised by Prof. Patrick Rensen, where specialised training on humanised mouse models for cardiometabolic diseases will explore the microbiome's causal role through human faecal transplantation in these models. This project will enhance the applicant's research capabilities and international network, fostering career development in metabolic disease and microbiome research. The findings from TREEGut will guide public health policies and clinical practices, contributing to the development of personalised, effective, and practical interventions to mitigate the impact of obesity-related diseases.

Keywords: gut microbiome,time restricted eating,metabolic dysfunction associated steatotic liver disease,physical activity,non communicable diseases,obesity,nafld
COx-free Hydrogen Production in Additively Manufactured Electrified Reactor through Catalytic Decomposition of Ammonia (CHyAMera)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia,Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 4
Project status: SIGNED

Europe’s transition to a decarbonised energy system, as outlined in the EU Green Deal, will radically transform how the EU generates, distributes, stores, and consumes energy. It will require virtually carbon-free power generation, increased energy efficiency, and the deep decarbonisation of transport, buildings, and industry. Europe is further boosting its green hydrogen ambitions to secure energy independence following the global geopolitical tensions and market instability. The current need to decarbonise our economy makes the search of new methods crucial to use chemicals, such as ammonia, that can be produced and employed as carbon-free (COx) hydrogen carrier. Dr. Milan Vukšić (applicant) will design and additively manufacture a modular, monolithic, multiscale ceramic catalytic reactor for magnetically heated COx-free hydrogen production with the fully electrified decomposition of ammonia. The project will be carried out at the Institute Jozef Stefan and the National Institute of Chemistry, Slovenia, under the supervision of Dr. Aljaž Iveković, Prof. Andraž Kocjan, and Prof. Blaž Likozar as consequence of a high level of interdisciplinary work. In contrast to the established stereolithography process, where ceramic filler particles are bound by a polymeric binder, the proposed project aims to form polymer-derived ceramic (PDC) structures by photopolymerisation of pre-ceramic polymers (PCPs) followed an additional heat treatment (pyrolysis) in collaboration with the TU Wien, supervised by Prof. Thomas Konegger. The main research focus will be on the additive manufacturing of ceramic catalytic reactor components with magnetic functionality induced by the in-situ formation of magnetic nanoparticles. The final goal of the project is to demonstrate the viability and advantages of the proposed approach for technical innovations and improvements in end systems that can use ammonia fuel.
TRUSTNEXUS: Trusted, Regulatory User-centric Services Tech portal for Next-generation Empowerment in identity eXchange and Unified Standards for access to services (TRUSTNEXUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Cyprus
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Trustnexus Smart Portal: AI-Driven Blockchain Infrastructure for Transforming Global Client Onboarding through Non-Discrimination, Citizen Data Sovereignty, Fraud Prevention, and Financial Crime Detection Trustnexus aims to revolutionize the digital infrastructure for KYC (Know Your Customer) and KYB (Know Your Business) processes by transforming fragmented, document-based onboarding into a unified, user-controlled trust ecosystem. Our vision is to establish European and global benchmarks for privacy-preserving, explainable, and non-discriminatory identity verification that empowers individuals as data owners while enabling institutions to combat financial crime effectively. The Trustnexus Smart Portal represents a category-shifting innovation integrating deep-tech AI (Bayesian anomaly Trustnexus is building the next-generation global digital trust infrastructure - an interoperable, user-governed portal that facilitates access to services across sectors and borders. Instead of fragmented onboarding or identity checks, trustnexus introduces an international federated network where individuals and businesses create, manage, and share their digital identity and credentials with full control and transparency. The portal enables secure, consent-driven access to a curated ecosystem of financial, legal, and public services, reducing duplication and inefficiencies across ecosystems. Backed by deep legal and compliance expertise, trustnexus is designed to adapt across jurisdictions, with embedded safeguards like 4-Eye verification and dynamic risk monitoring. Users retain full control over their data – know what they have shared, with whom, and are able to revoke access at any time. More than just a product, we are shaping a decentralized, interoperable network of trust that scales across verticals and borders. Designed for global relevance with regional compliance adaptability, we are enabling frictionless access to the digital economy – without compromising user agency.

Keywords: regulatory technology,deep tech,blockchain,security,user empowerment,data protection,ethical ai
QuiX Quantum Universal Quantum Processor (QUQUP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: Emerging quantum technology components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 3528750.0
EU funding (EUR): 2470125.0
Participants: 2
Project status: SIGNED

Quantum computing is a technological revolution that will unleash the most dramatic changes in our everyday lives since the invention of the internet. Quantum computing has the power to impact every major global industry, from pharmaceutical research to climate action and personalized healthcare to space travel. However, today’s quantum technologies still suffer several drawbacks. They require cumbersome and rigid hardware, such as cooling to almost absolute zero, and suffer from both noise and decoherence. QuiX Quantum is bringing to market the first scalable universal quantum processor based on our disruptive photonics innovation. For the first time, we will be offering a scalable, marketable universal quantum processor that can be adopted by companies, research institutes, and government organizations to change the world in which we live. We are seeking EIC support in the form of blended finance to bring our first universal quantum processor product to market as early as 2026.