Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
RENEWABLE ECO-FRIENDLY POLY(LACTIC ACID) NANOCOMPOSITES FROM WASTE SOURCES (ECLIPSE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Spain,Belgium,Colombia,Spain,Chile,Sweden,Germany,United Kingdom,Belgium,Spain
Call:  (FP7-NMP-2011-SMALL-5, 2011)
Start date: 2012-04-01
End date: 2015-03-31
Duration (months): 36.0
Total project cost (EUR): 5282470.2
EU funding (EUR): 3725000.0
Participants: 13
Project status: CLOSED

Poly(lactic acid) (PLA) is a compostable polymer derived from renewable food-derived sources (mainly starch and sugar beet) and possesses the highest potential for a commercial major scale production of renewable packaging materials. Since PLA is compostable and derived from sustainable sources, it can be envisaged as a promising material for the reduction of the enormous societal problems associated to solid waste disposal. ECLIPSE promotes a more sustainable and environmentally friendly approach to packaging, via the use of waste derived materials unrelated to fossil fuels and to the food chain. The main objective of ECLIPSE is to revalorize waste-derived products (algae biomass waste and plant and crustacean wastes) into novel packaging materials. The ECLIPSE approach intends to revalorize waste materials for the production of an algae-derived PLA matrix. In addition, ECLIPSE also seeks to reinforce such PLA matrix with functionalized nanofillers extracted from non-edible banana plant, almond shell and crustacean shell wastes. This project aims at decreasing both the production costs of both poly(lactic acid) and algae biodiesel, by increasing the added value of algae waste via its revalorisation into the production of lactic acid. To this purpose, the industrial partnership was designed to combine leading companies to supply the raw materials involved in the project, namely algae (ALGAENERGY), lactic acid (GALACTIC), PLA (FUTERRO), banana waste (BANACOL) and seafood waste (ANTARTIC), with sound research groups active on biopolymers and nanoparticle functionalisation and dispersion (UMONS, CIDETEC, FRAUNHOFER, LTU, UPV/EHU, UPB, PUC) and a global end user with multiple plastic packaging converting facilities. This consortium includes 9 partners from European institutions and 4 partners from South American SICA countries, all of them experts in their respective fields.

Keywords: poly(lactic acid),algae-derived biopolymers,polysaccharide-based nanoparticles,functional inorganic fillers,cellulose and chitin nanofillers,nanoclays,gas barrier,waste revalorisation
Innovative Technologies and Concepts for the Intelligent Deep Mine of the Future (I²MINE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Sweden,Finland,Sweden,Sweden,Germany,Poland,Germany,Belgium,Germany,France,Germany,Poland,Switzerland,United Kingdom,Germany,Austria,Slovakia,Germany,Germany,Austria,Slovakia
Call:  (FP7-NMP-2011-LARGE-5, 2011)
Start date: 2011-11-01
End date: 2016-03-31
Duration (months): 53.0
Total project cost (EUR): 25922250.8
EU funding (EUR): 15999203.0
Participants: 26
Project status: CLOSED

The mine of the future will exploit mineral raw materials at greater depths than today, requiring completely different approaches compared to today’s deep mines, in order to get mineral rights. Only these eco-efficient mines will contribute to improved access to domestic mineral resources, secure the supply of mineral raw materials for Europe and reduce the import dependency. IntelliMine will contribute to realise these concepts of invisible, zero-impact and safe mines. The mine of tomorrow will run an integrated concept. All operations necessary for the eco-efficient provision of the minerals including waste management will be carried out underground. This will drastically reduce the volumes being transported, minimising above ground installations and thus the environmental impact. IntelliMine will develop innovative methods, technologies, machines and equipment for the safe, eco-innovative, intelligent and economical exploitation of mineral raw materials in the EU, including maintenance issues, especially at greater depths. It will investigate autonomous, highly selective mineral extraction processes and machinery based on new sensor technologies as well as innovative concepts for mass flow management and transportation. Such investigations have to be accompanied by rock mechanics and ground control issues as well as health, safety and environmental issues. The concept of an invisible, zero-impact mine requires a refined process underground that selectively extracts the minerals and therefore reduces waste production closer to the mineralisation. Therefore improved near to face processing methods including backfill procedures need to be developed. The necessary level of automation in mining operations can only be achieved by reaching a higher level of integration in all parts of a mine. Fully integrated underground technologies and processes for diagnosis and extraction as well as communication, health and safety issues are the key for the success of the concept.

Keywords: mining,mineral raw material supply,resource efficiency,deep mining,eco-efficient mining,minerals extraction,invisible mine,near to face processing,mining concepts,zero-impact mine
Time dynamics and ContROl in naNOStructures for magnetic recording and energy applications (CRONOS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Ireland,Germany,Spain,Spain,Finland,Italy,Germany,Switzerland,France,Finland
Call:  (FP7-NMP-2011-SMALL-5, 2011)
Start date: 2012-06-01
End date: 2015-05-31
Duration (months): 36.0
Total project cost (EUR): 4374349.0
EU funding (EUR): 3380058.0
Participants: 10
Project status: CLOSED

The CRONOS project seeks to develop a quantitative, flexible and fully atomistic theory of ultrafast dynamics in real materials. Our effort will create the necessary knowledge for advancing two technological areas crucial for the economic future of Europe and the well being of its citizens: new materials for solar energy harvesting and ultra-high density magnetic data storage. In particular we will construct the necessary theoretical tools for addressing the problems of energy photo-conversion and laser-induced ultrafast magnetization dynamics. Crucially CRONOS will not just look at how an optical excitation perturbs a materials system but also at how such an excitation can be engineered to produce a desired response. Hence both the direct and the inverse problem will be tackled. CRONOS’ theoretical program will be validated by a broad experimental activity on ultra-fast pump-probe spectroscopy and by the presence in the consortium of European companies. Equally important is the fact that the consortium will produce a substantial amount of high-end scientific software, which will then be distributed freely to the academic community. The project will develop a quantitative and materials-specific theory for electron dynamics in nano-structures, which, at the same time, is fully atomistic, efficient, scalable to large systems, and rigorously theoretically formulated. The core of our method is time-dependent density functional theory, TDDFT, which was invented by a member of our consortium and has been developed over the years . Our workplan comprises formal methodological development, algorithm implementation, applications to both solar cells and magnetic recording, and experimental validation. A significant deliverable of this project will also be the wide distribution of computational packages

Keywords: atomistic theory,ultrafast dynamics,solar energy,ultrafast magnetization dynamics,pump-probe spectroscopy,photovoltaics,density functional theory,time dependent density functional theory
Contamination and defect control for increased yield for large scale R2R production of OPV and OLED (CLEAN4YIELD)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Netherlands,Germany,Denmark,United Kingdom,France,Netherlands,Germany,Germany,United Kingdom,Germany,United Kingdom,Germany,Israel,Switzerland
Call:  (FP7-NMP-2011-LARGE-5, 2011)
Start date: 2012-05-01
End date: 2015-04-30
Duration (months): 36.0
Total project cost (EUR): 10431146.03
EU funding (EUR): 7060000.0
Participants: 19
Project status: CLOSED

While nanotechnology was originally limited to small areas of a few cm2, the quest for lower costs has been the latest years the drive for developing processes utilising larger substrate sizes at increasing throughputs. A typical example is the flat panel display industry where the push to larger gen size and faster processing has resulted in a significant cost reduction. The next challenge here is the move to smaller feature sizes. Large area processing at high speeds is optimal when using roll-to-roll (R2R) processing, able to deliver the ultimate cost reduction. Flexible innovative thin film devices, like organic light emitting diodes (OLEDs) for lighting, photo voltaic (PV) and organic photo voltaic (OPV) modules, organic circuitry, printed electronics and thin film batteries, are currently developed using this kind of processing. The overall objective of Clean4Yield is the development and demonstration of technologies and tools for nano-scale detection, cleaning, prevention and repair of defects and contaminations in nano-scale layers. The R2R production processes for OLED, OPV, and high-end moisture barrier layers on flexible substrates will serve as development platform for the various methods. Clean4Yield will demonstrate that the developed methods increase yield, reduce production costs, and improve performance and operational device lifetimes of these applications. The developed technologies will be easy to adapted for other large-scale production technologies of other nano layer applications.

Keywords: defects,contamination control,repair,nanolayers,r2r production,oled,opv,barrier layers,yield increase,cost reduction,flexible substrates,lifetime improvement,performance improvement
Rights, Responsibilities, and the HIV/AIDS Pandemic: Global Impact on Moral and Political Subjectivity (AIDSRIGHTS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Institutions, values, beliefs and behaviour
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101124, 2011)
Start date: 2012-05-01
End date: 2017-04-30
Duration (months): 60.0
Total project cost (EUR): 1499370.0
EU funding (EUR): 1499370.0
Participants: 1
Project status: CLOSED

This project will undertake a transnational, multi-sited ethnographic study of moral and political subjectivity in HIV/AIDS prevention and treatment programs from the perspective of socio-cultural anthropology. The main research question is: what kinds of politico-moral persons are constituted in institutional contexts that combine human rights and personal responsibility approaches to health, and how these kinds of subjectivities relate to local, national, and global forms of the politico-moral represented in health policies? In particular, this research will be carried out in Indonesia (Jakarta and Bali), South Africa (Western Cape), USA (New York City), and various locations throughout Eastern Europe in HIV/AIDS programs and institutions that increasingly combine human rights and personal responsibility approaches to treatment and prevention. This project is the first anthropological research on health governance done on a global scale. Until now most anthropological studies have focused on one health program in one location without simultaneously studying similar processes in comparable contexts in other parts of the world. In contrast, this project will take a global perspective on the relationship between health issues, morality, and governance by doing transnational multi-sited research. This project will significantly contribute to the current anthropological focus on bio-citizenship and push it in new directions, resulting in a new anthropological theory of global bio-political governance and global politico-moral subjectivities. This theory will describe and explain recent transnational processes of shaping particular kinds of politico-moral subjectivities through health initiatives. By doing research in comparable world areas this project will significantly contribute to the development of a theory of politico-moral governance with global reach.

Keywords: human rights,responsibility,hiv/aids,institutions
Neuronal circuits controlling fear behavior (NEUROFEAR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: France
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1496300.0
EU funding (EUR): 1496300.0
Participants: 1
Project status: CLOSED

Accurate adaptation to stimuli predicting threatening outcome is critical to survival. An insufficient fear reaction may lead the animal to overlook future signs of danger, whereas overreacting may lead the animal to failure to explore and miss opportunities for feeding or mating. Numerous data indicate that the medial prefrontal cortex (mPFC) plays a key role in the control of fear behavior and that distinct prefrontal areas differentially regulate the expression/inhibition of fear responses. Whereas lesions/inactivations of the mPFC infralimbic (IL) area promote fear expression, lesions/inactivations of the mPFC prelimbic area (PL) promote fear inhibition. Moreover, PL and IL receive segregated inputs from functionally distinct amygdala circuits activated during high and low fear states. These data suggest that a key function of mPFC circuits might be to integrate inputs from the amygdala to ultimately gate fear expression via projections to specific neuronal circuits. However, little is known about the underlying neuronal circuits. Is the rapid switch between expression/suppression of fear behaviors mediated by the same circuits or does the mPFC contain distinct circuits dedicated to the control of opposite behaviors? Is there an organization in terms of afferents and efferent at the level of mPFC neuronal circuits? To address these questions we will use a cross-level approach combining in vivo electrophysiological optogenetic and behavioral approaches to elucidate the anatomical/physiological properties of mPFC circuits and to address their functional role in the control of fear behavior. We will first examine the activation and connectivity of mPFC circuits using in vivo extracellular recordings and extracellular stimulations. We will next selectively manipulate these circuits during behavior using light-activated proteins to establish causal relationships. Finally we will study their plasticity and anatomical properties using in vivo intracellular recordings.

Keywords: fear conditioning - fear extinction - behavioral electrophysiology - medial prefrontal cortex - amygdala - neuronal circuits
Harnessing systems immunology to unravel dendritic cell subset biology (SYSTEMSDENDRITIC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-02-01
End date: 2017-07-31
Duration (months): 66.0
Total project cost (EUR): 1498821.6
EU funding (EUR): 1498821.6
Participants: 1
Project status: CLOSED

The development of better vaccines against cancer or intracellular pathogens is a major challenge of immunological research. Novel approaches are needed to induce efficient, long-lasting memory CD8 T cell (CTL) responses. The CD8α subset of mouse dendritic cells (mDC) is specialized in this function, excelling at antigen cross-presentation. Their targeting in vivo for vaccination yielded encouraging results. How to translate this strategy for human health was not obvious, because no human DC (hDC) subset equivalent to CD8α mDC had been discovered. Investigating the relationships between mDC and hDC subsets was hampered by the use of different markers for their identification. To overcome this problem, we used comparative genomics to unravel potential equivalences between mDC and hDC subsets based on the similarities of their gene expression programs. This led us to demonstrate that BDCA3 hDC are professional cross-presenting DC equivalent to CD8α mDC. However, we still do not know what the extent of the physiological functions of different DC subsets is, and we largely ignore how they are regulated. We propose a major and innovative effort to investigate in parallel in mouse and human the biology of two DC subsets thought to be important for antiviral and antitumoral defence: plasmacytoid DC and professional cross-presenting DC. We designed a Systems Biology approach to uncover key functions and regulatory pathways conserved in these cells. We will investigate DC subset functions and their regulation in vivo during infectious challenges, by using state-of-the-art technology to generate and analyse novel high throughput data and innovative mutant mice. We will directly translate to human the knowledge obtained in the mouse, through comparative genomics and in vitro experiments on hDC. This approach is the first of this kind, at the forefront of creating new knowledge to understand the pivotal role of DC subsets in immunity and to manipulate them for promoting health.

Keywords: cross-presenting dendritic cells plasmacytoid dendritic cells
Uncovering the Mechanisms of Cardiomyocyte Differentiation and Dedifferentiation (CM TURNOVER)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Israel
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The quest to restore damaged organs is one of the major challenges in medicine. Recent studies in both animals and in humans suggest that the heart has a limited capacity to replenish its own cardiomyocytes (CMs) throughout life, albeit inadequate to compensate for major injuries such as acute myocardial infarction (MI). Most therapeutic research in regenerative cardiogenesis is geared toward stem cell therapy as a means to replace lost CMs associated with ischemic heart disease. Clinical data evaluating the efficacy of cell-based therapy for heart disease are relatively disappointing. This proposal encompasses multidisciplinary and novel approaches to study the molecular and cellular mechanisms that govern the proliferation, differentiation and dedifferentiation of endogenous CMs, combining developmental-, systems- and cell-biology methodologies in vitro and in vivo, in chick, rodent, and human tissue samples. First, we will perform combinatorial perturbations of signaling pathways in chick embryos, focusing primarily on the FGF-ERK pathway, to investigate the molecular switch between cardiac progenitors and CMs (Aim 1). Because adult CMs have limited proliferative capacity, mainly due to mechanical constraints, in Aim 2, we will apply state-of-the-art techniques in cell biology, to determine whether specific mechno-transduction stimuli can prime the proliferation of differentiated CMs. In order to gain deeper insights into the capacity of adult CMs to renew themselves under normal and pathological conditions, in Aim 3, we will employ a novel cell lineage methodology in mouse and human tissue, based on information encoded in genome. Using this methodology, we hope to shed light on the maintenance, renewal and regenerative capacities of adult CMs in vivo. The expected outcome will be a significantly greater understanding of the bidirectional transition from proliferating cardiac progenitors into differentiated CMs, in embryonic and adult hearts.

Keywords: heart development and repair,cardiomyocyte renewal,cardiomyocyte proliferation
Human Evolutionary Immunogenomics: population genetic variation in immune responses (EVOIMMUNOPOP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: France
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-01-01
End date: 2017-08-31
Duration (months): 68.0
Total project cost (EUR): 1494756.0
EU funding (EUR): 1494756.0
Participants: 1
Project status: CLOSED

Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into the nature of the genetic, biological and evolutionary relationships underlying such complex phenotypes. There is thus a growing need for approaches that provide a mechanistic understanding of how genetic variants function to impact phenotypic variation and why they have been substrates of natural selection. One set of traits that displays considerable heterogeneity and that has undoubtedly been shaped by natural selection is the host response to microorganisms. By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the natural setting and how this phenotypic variation is under genetic control. Specifically, we aim (i) to characterise the genetic architecture of two populations differing in their ethnic background; (ii) to define individual and population-level variation in immune responses, in the same individuals, by establishing an ex vivo cell-based model to study levels of transcript abundance of both mRNA and miRNA, before and after activation with various immune stimuli; (iii) to map expression quantitative trait loci associated with variation in immune responses; and (iv) to identify adaptive immunological phenotypes. This study will increase our understanding of how genotypes influence the heterogeneity of immune response phenotypes at the level of the human population, and reveal immunological mechanisms under genetic control that have been crucial for our past and present survival against infection. In doing so, we will provide the foundations to define perturbations in these responses that correlate with the occurrence of various infectious and non-infectious diseases as well as with vaccine success.

Keywords: genomics population genetics immunity natural selection genotype-phenotype correlations gene expression mirnas