Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space (RECON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

Despite the abundance of organic compounds in Nature, only 12 contain fluorine. In contrast, fluorinated organic materials account for over 40% of all pharmaceuticals and agrochemicals. Closer inspection of the fluorination patterns in these functional molecules reveals striking extremes towards perfluorination (in both 2D and 3D scaffolds) or single site fluorination predominantly in aryl substituents. Consequently, most fluorinated moieties in functional materials lack stereochemical information and are thus achiral. This disparity between the paucity of naturally occurring organofluorine compounds and their venerable history in functional molecule design confirms the enormous potential of fluorinated materials in the discovery of novel properties. That progress has largely been confined to 3 dimensional achiral and 2 dimensional achiral architectures reflects the synthetic challenges associated with preparing stereochemical defined multiply fluorinated systems. A major limitation in the construction of C(sp3)-F units remains the need for substrate pre-functionalisation via oxidation and the competing substitution/elimination scenario that compromises efficiency in the deoxyfluorination. This problem is magnified in the synthesis of optically active fluorides where the deoxyfluorination can compromise the enantiopurity of the starting materials. The principle aim of RECON is to facilitate exploration of 3D, chiral space by providing access to multiply fluorinated, stereochemically complex organofluorine materials from simple feedstock using inexpensive, commercially available fluoride sources. In providing a modular platform to rationally place function on a structural basis, exploration of uncharted chemical space will accelerate the discovery of next generation materials for medicinal and agrochemistry, material sciences and bio-medicine.

Keywords: fluorine,stereoelectronic effects,catalysis,organofluorine chemistry,chiral
Earth observation and Earth GNSS data acquisition and processing platform for safe, sustainable and cost-efficient mining operations (Goldeneye)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Ukraine,Austria,Germany,Spain,Israel,Bulgaria,Finland,Romania,Finland,Romania,Belgium,Slovenia,Finland,Netherlands,Kosovo
Call: Raw materials innovation actions: exploration and Earth observation in support of sustainable mining (H2020-SC5-2019-2, 2019)
Start date: 2020-05-01
End date: 2023-10-31
Duration (months): 42.0
Total project cost (EUR): 10838613.44
EU funding (EUR): 8360389.95
Participants: 17
Project status: SIGNED

The Goldeneye project will implement a unique combination of remote sensing and positioning technologies, exploiting Earth observation and Earth GNSS data, together with data fusion and processing powered by data analytics and machine-learning algorithms. The platform will allow satellites, drones and in-situ sensors to collect high-resolution data of the entire mine, which can be processed and converted into actionable intelligence for safety, environmental monitoring and overall productivity, allowing more efficient exploration, extraction and closure. These tools will be demonstrated in 5 field trials in Germany, Bulgaria, Romania, Kosovo and Finland, creating a compelling value proposition for implementation across the mining industry value chain. The project has a duration of 3 years and an EC funding of €8.36M. The consortium includes a large industrial partner, 7 SMEs, 4 academic/research centres and 4 end-users, supported by a strong advisory board of experts in geosciences.

Keywords: data fusion,extraction,exploration,closure,safety,sustainability,economics
YAK kinase regulated trypanosome quorum sensing (TRYP-QS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-05
End date: 2017-05-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.

Keywords: trypanosoma,cell signalling,quorum sensing,protein kinase
HUMANISM BEHIND THE IRON CURTAIN: ITALIAN RENAISSANCE STUDIES IN THE SOVIET UNION (RENAISSANCE USSR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2025-04-02
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

The main goal of the project is to examine the Italian Renaissance Studies in the Soviet Union taken as an independent and considerably isolated scholarly tradition, but placed in the broader context of intellectual history and development of Renaissance historiography in the twentieth century. The project seeks to comprehend why and how Italian Renaissance philosophy, art and history was extensively studied in Soviet Union, what was the contribution of the Soviet scholars to the field on the international level, that is how they reshaped our understanding of this movement, and how these scholars, whose financial opportunities and academic mobility were significantly limited, participated in the international academic networks. The project will be the first comprehensive study of the Italian Renaissance scholarship in the Soviet Union examined as independent national tradition, but placed in the international discourse on Renaissance humanism. The project will contribute to the field of Renaissance Studies, Russian/Soviet studies, comparative and global intellectual history, and gender studies.

Keywords: historiography of renaissance,renaissance humanism,russian and soviet studies,global history of historiography
Quantifying Abrupt Biotic Responses to Palaeoclimate Change (ABRUPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-11
End date: 2018-04-10
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Climate change in the 21st century is predicted to push ecosystems across ecological thresholds, potentially resulting in abrupt ecosystem change into new and irreversible states. Ecological theory proposes that non-linear biotic responses are the result of a complex interplay of feedbacks, thresholds and interactions that operate over decades to thousands of years. As a result, standard ecological research methods are generally unable to quantify key ecological dynamics that are relevant for forecasting abrupt ecological change and there is a critical need to integrate long-term ecological data with process-based models. This will result in improved forecasting of climate-change impacts on ecosystems at both local- to global-scales. Such studies will play a critical role in understanding the ‘intrinsic’ factors (e.g. climate-vegetation feedbacks) that can result in non-linear biotic responses to climate change. Sediments are natural data-loggers that preserve the remains of plants and animals over thousands of years. They provide a unique resource for answering current high priority questions related to predicting future ecosystem change because they are the only way to obtain empirical information relevant for understanding long-term ecological dynamics and functioning. In this project I will develop an interdisciplinary framework that integrates state-of-the-art process-based modelling with new high-quality palaeoecological information to quantify the factors that result in non-linear responses to climate change. I will apply the framework to a major vegetation transition in the past: the sclerophyll-rainforest transition in north-east Australia that occurred between 10 and 7 thousand years ago. I will develop this case study for proof-of-concept of a new interdisciplinary framework. This will result in a greater understanding of non-linear biotic responses to climate change.

Keywords: dynamic vegetation modelling,ecological thresholds,climate change,leaf wax isotope ratios,water stress,rainforest,holocene,atherton tableland,bayesian statistics
Chemical Hematology: breaking resistance of hematological malignancies through personalized drug trials (chemos)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-10-01
End date: 2017-09-30
Duration (months): 12.0
Total project cost (EUR): 146668.0
EU funding (EUR): 146668.0
Participants: 1
Project status: CLOSED

Personalized medicine aspires to provide optimal therapy in real-time during patient treatment, however current methodology falls short to deliver this in a robust manner. With this in mind, we invented a method for the screening of thousands of drug responses in small samples of an individual’s peripheral blood by automated microscopy and single-cell image analysis. We termed this method pharmacoscopy. In the course of carrying out the i-FIVE ERC grant project plan, we began screening for novel anti-viral or immune modulating drugs. In the quest to increase the physiological relevance of our screening settings, we investigated the possibility of using peripheral blood cells or bone marrow from individuals. We have thus far been able to show that the approach allows for the screening of anti-inflammatory properties of compounds, and to score for distinct sub-population specific cell cytotoxicity profiles of clinical anti-neoplastic agents through the tracking of fluorescent antibodies and probes. Moreover, we have been able to show that the approach empowers the therapeutic decision-making capability of hema-oncologists in a concrete clinical setting using primary myelofibrosis and lymphoma as test diseases. With funding from this grant, we intend to obtain further clinical data through retrospective trials, and incorporate the results into an information package attractive enough to draw the attention of potential investors. We have secured the intellectual property rights and have assembled the know-how required to enable commercialization efforts. With the unique image-based single cell analysis of human liquid tissues, we believe that chemos has the potential to develop into a service that enables and advances personalized medicine and drug discovery for a broad spectrum of hematological disorders.

Keywords: personalized medicine,blood cancer,image analysis,chemosensitivity,lymphoma,leukemia
Optimized cockpit windshield for large diameter business aircraft (OptiWind)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Optimized cockpit windshields for large diameter business aircrafts (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2023-04-30
Duration (months): 62.0
Total project cost (EUR): 1315162.5
EU funding (EUR): 965388.75
Participants: 2
Project status: SIGNED

The proposed project addresses the topic “Optimised cockpit windshield for large diameter business aircraft”. The main objectives are i) to optimise the design of aircraft windshield and surrounding structure in terms of technical performances (low weight, high capacity to bear loads, reduced noise) and operational performances (low recurring costs, easy maintainability) and ii) to optimise heating power consumption for anti-icing. Other objectives are: - To develop models to support windshield design and to analyse power consumption for anti-icing and defogging; - To propose five concepts based on different assembly techniques and transparencies; - To support certification with heating power density lower than the currently used value of 70 W/dm2; - To develop a front aircraft demonstrator and to validate the selected concept;- To assess environmental impact of the proposed technologies; - To set the ground for future exploitation of the project results. The project starts with the definition of specifications and a review of latest emerging technologies to propose five improved window concepts. Models and simulation capabilities will be developed and validated for the optimisation of the heating power stream. A trade-off solutions between the five concepts will be proposed. A full scale front aircraft demonstrator will be developed to assess the performances of the selected optimised solution and its compliance. Two partners will collaborate in the project: Company Saint-Gobain Sully, a long-time supplier of transparencies in the aerospace market and University Savoie Mont-Blanc through two research laboratories specialised in modelling.

Keywords: windshield,innovative,birdstrike,heated,de icing,modelling
ML-powered app and platform to identify skin changes over time (Miiskin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Malignant Melanoma (MM) is a tumour which originates mostly in the skin melanocytes and is responsible for most deaths caused by skin cancer, due to the high risk of lymphatic metastases and expansion to other areas of the body. Globally, 232,000 people are diagnosed with MM every year, 90,000 of those concentrated in Europe. While early detection of melanoma has a 98% survival rate, late detection has only a 10-25% survival rate, with a mortality rate going from 3% in countries like Norway or Denmark to 6-7% in other areas close to the poles like South Africa or Australia. Treating MM cost to the healthcare system a minimum of €10,000 to €250,000€ per patient. People at high risk of developing MM or healthy people who has previously been diagnose with MM skin cancer have to regularly monitor their skin and moles for changes. Any skin/mole change can be an early sign of skin cancer and early detection of melanoma is crucial for successful treatment. Nevertheless, the process of spotting manually new changes in the skin can be highly time consuming and unprecise, as it is done manually or using commercial apps (MelApp, SkinVision) lacking clinical certification. We have created, Miiskin app as a supporting tool to help users to monitor skin changes over time with an innovative technology application based in artificial intelligence. Thanks to our innovation, we made the monitoring process more efficient and reliable, helping in the identification of new moles through automatic photo comparison. Moreover, Miiskin will be used as patient-doctor node fully unlocking the potential of teledermatology. Thanks to that we are the unique app worldwide bearing the dermatologically endorsement quality seal. We have already acquired a strong and highly competitive market position as well as the highest rate among Skin Cancer apps, involving more than 400,000 users worldwide. With this ambition we aim to reduce skin cancer mortality to 1% by 2030.

Keywords: melanoma,skin cancer early detection,ai powered app for skin monitoring,tool to identify skin changes,dermatologically endorsed skin monitoring app
On demand design of reversible shape changing metamaterials (METADESIGN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 149752.5
EU funding (EUR): 149752.5
Participants: 1
Project status: CLOSED

We propose to commercialize a software for the automatic design of responsive metamaterials structures for additive manufacturing. During the course of the ERC AdG SIZEFFECTS project, the PI studied the effect of disorder on the mechanics of materials using discrete elements models (DEM), allowing for an efficient simulation of large disordered structures, including metamaterials. The METADESIGN project exploits DEM methodologies and optimization algorithms developed throughout the SIZEFFECTS project to solve the general problem of efficient and automatic design of responsive metamaterials machines. The algorithms put forward by the METADESIGN project is able to produce generic elementary metamaterial actuators with a broad set of possible movements and efficiencies. We propose a commercialization strategy that aims at deploying the software on the cloud allowing for flexible on demand services. Industrial partners and target costumers will be searched in the automotive, robotics and manufacturing industries.

Keywords: metamaterials,additive manufacturing,3d printing,elasticity,computational methods
Polariton logic (POLLOC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,France,France,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 2739873.75
EU funding (EUR): 2739873.75
Participants: 6
Project status: SIGNED

For energy-efficient computation beyond the current CMOS paradigm, tweaking the current nanoelectronics roadmap will be neither enough nor sustainable, but requires to completely rethink transistor devices and circuits. Leveraging recent breakthroughs in perovskite nanomaterials and room-temperature exciton-polariton devices achieved by the consortium partners, we believe that now the time has come to take this beyond the scieFor energy-efficient computation beyond the current CMOS paradigm, tweaking the current nanoelectronics roadmap will be neither enough nor sustainable, but requires to completely rethink transistor devices and circuits. Leveraging recent breakthroughs in perovskite nanomaterials and room-temperature exciton-polariton devices achieved by the consortium partners, we believe that now the time has come to take this beyond the scientific publication level and build a novel technology that can leapfrog established architectures. Within POLLOC we aim for the development of a complete technology platform for universal photonic information processing based on exciton polariton condensates in microcavities with inorganic perovskites. We will validate this new technology with respect to the key parameters power, energy-efficiency, size, frequency, and cost. In the digital processing domain, we aim for optically programmable, cascadable logic gates with less than 100 attojoule switching energy and sub-picosecond switching speed. To fulfil the requirements of this disruptive all-optical device and circuitry approach, POLLOC assembles the whole gamut of necessary expertise from chemistry, physics, theory and technology. The carefully chosen, well-balanced consortium consists of leading partners from academia, SME and large end-user with excellent track records that are uniquely positioned to tackle the ambitious goal to unleash the potential disruptive performance gains of this technology and to establish a new kind of digital and analog circuitry paradigm.

Keywords: perovskites nanoplatelets,polariton transistor,polariton logic circuitry