Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protection of Redox Catalysts for Cathodic Processes in Redox Matrices. (REDOX SHIELDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1483092.5
EU funding (EUR): 719636.24
Participants: 2
Project status: CLOSED

Biological or molecular catalysts built from Earth-abundant elements are envisioned as economically viable alternatives to the scarce noble metals that are currently used in renewable energy conversion. However, their fragility and O2 sensitivity have been obstacles to their adoption in industry. We have recently proposed O2 quenching matrices for protecting intrinsically O2-sensitive catalysts for use in anodic (oxidative) processes. We have demonstrated that even hydrogenases, the highly sensitive metalloenzymes that oxidize H2, can be used under the harsh conditions encountered in operating fuel cells. However, attempts to reverse the concept for the protection of cathodic (reductive) processes, such as H2 evolution, have been unsuccessful so far. In this case, the electrode generates the reducing agents in the form of electrons, which are needed for both H2 generation and reductive O2 quenching. The competition between the two reactions results in insufficient protection from O2 and deactivation of the catalyst. The objective is to design an alternative electron pathway that relies on H2 as a charge carrier to efficiently shuttle the reductive force to the matrix boundaries and quench the incoming O2. We will develop novel electron mediators with dual functionalities to enable the reversible H2/H+ interconversion and to achieve the complete reduction of O2 to water. We will focus on organic systems, as well as metal complexes based on Earth-abundant elements with tunable ligand spheres, to adjust their redox potentials for the desired direction of the electron flow and toward fast O2 reduction kinetics. The synthetic efforts will be supported by electrochemical modelling to predict the required properties of the redox matrix for efficient protection. After establishing the protection principle, we will demonstrate its practical use for implementing sensitive bio-catalysts for electrochemical H2 evolution under conditions relevant to energy conversion processes.
Measuring automotive exhaust particles down to 10 nanometres (DownToTen)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Austria,Germany,Italy,Finland,Belgium,Greece,United Kingdom
Call: Technologies for low emission light duty powertrains (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2019-12-31
Duration (months): 39.0
Total project cost (EUR): 4135133.75
EU funding (EUR): 4135133.75
Participants: 10
Project status: CLOSED

DownToTen will seek to develop a reliable and robust methodology to enhance the regulatory approach in the assessment of particle number emissions in the sub 23nm region (down to at least 10nm), focusing on state-of-the art automotive powertrains with direct injection gasoline engines, but also diesel ones, under real-world operation conditions. To this end, DownToTen will first investigate and quantitatively describe the nature and the characteristics of nanoparticles <23 nm (formation, origin, physical and chemical character), and will set up a synthetic aerosol bench for fundamental studies at instrument level for the facilitation of metrology and evaluation purposes. Existing, proposed and under development instruments will be evaluated against rigorous criteria for the measurement of sub 23 nm particles, with emphasis on their applicability as portable emissions systems (PEMS). The best candidate systems will then be thoroughly tested in a well-defined set of criteria and under varying conditions of challenging aerosol from a variety of sources, to select the most promising combinations for further usage. At the next steps, a PN-PEMS demonstrator will be selected to materialise the relevant findings and suggestions, and its efficiency to determine PN emissions of current and future engine and vehicle technologies will be explored in the laboratory and in real world conditions (RDE). Further, an appropriate sampling and measurement methodology for <23m particles will be proposed based on literature survey and the laboratory and on-road testing results, which will assist in the determination of future PN emission limits and conformity factors for vehicle and engine type approval, primarily for RDE. DownToTen also aims to assess the fraction of particles left of control from current and future regulations, which will assist researchers to better understand the impacts of exhaust particles on air pollution.

Keywords: automotive,particle number,exhaust gas,emissions,regulations
Ancient scholarship on archaic Greek iambic poetry (ASAGIP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The proposed research concerns ancient scholarship on archaic Greek iambic poetry from the Hellenistic to the Byzantine period. It investigates the history of such scholarship in its various embodiments (editions, commentaries, marginal annotations, monographs on individual topics, author- and genre-specific lexica, and others) and the aims, concerns, assumptions, and techniques that it deployed. This investigation - the first of its kind - aims to contextualise such items of scholarship, and scholarship on iambos generally, within the broader picture of ancient literary scholarship. The study of ancient scholarship is a budding field, making the proposed research timely as well as necessary. Ancient scholarship has long been among my research interests. Given the Department's strengths on archaic Greek poetry and ancient scholarship, and Ca' Foscari's commitment to fostering research and supporting young researchers' skills development, Venice is the ideal partner for the success of the proposed research. Holding a Marie Sklodowska-Curie would be highly beneficial to my academic career and enable me to achieve independence as a professional researcher.

Keywords: ancient scholarship,iambic poetry,papyrology,marginalia,lexica,archilochus,hesychius,tzetzes
Pharmaceutical Education And Research with Regulatory Links: Innovative drug development strategies and regulatory tools tailored to facilitate earlier access to medicines (PEARRL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Ireland,Switzerland,Greece,Belgium,Greece,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-05-01
End date: 2020-08-31
Duration (months): 52.0
Total project cost (EUR): 3856253.04
EU funding (EUR): 3856253.04
Participants: 10
Project status: CLOSED

The European Pharma industry is a major contributor to EU well-being, both in public health and economic (sales >200 billion €/year) terms. To maintain global leadership, it must respond to challenges from low-cost producers e.g. China by bringing new drug molecules to market in a streamlined, cost-effective manner. This strategy is underscored by recent initiatives of European regulators to expedite the approval of “breakthrough drugs” so patients can gain earlier access to life-saving drugs. To realise these goals, scientists with an integral understanding of drug development and regulatory approval processes are urgently needed. PEARRL will train 15 Early Stage Researchers (ESR) who can develop new bio-enabling formulations (“better drugs”), biorelevant and in silico methods to predict formulation performance in vivo (“streamlined development”) and serve as communication bridgers between research and regulatory science (“accelerated approval”), thus bringing Pharma and regulatory objectives to fruition. PEARRL brings a multi-sectorial team, comprising key European regulatory authorities, academic leaders in bio-enabling formulations and biopharmaceutics tools, and an array of Pharma companies with a wealth of combined experience in bringing molecules to market, together for the first time to deliver a unique research and training programme. Key PEARRL elements are individual research projects with synergistic output; exposure of all ESR to academia, industry and regulatory in secondments; and ongoing innovative learning via Online Portals, Science Slams and Boot Camps. Key PEARRL impacts will be availability of excellent pharmaceutical researchers; streamlined drug development with a higher success rate for the industrial partners; enriched academic research through cooperation with industry and regulatory; earlier availability of breakthrough medicines to patients; a competitive pharma industry in Europe and contributions to European public health interests.

Keywords: pharmaceutics,drug development,pharmacokinetics,oral bioavailability,regulatory science,molecule to medicine,drug formulation,oral drug delivery,biorelevant testing
Using reaction norms to identify glucocorticoid phenotypes and their relationship to fitness in individuals of a wild vertebrate. (CortFit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Environments are currently changing at unprecedented rates, but the evolution of endocrine response mechanisms is still hardly understood. As environmental transducers, hormone levels are plastic, and basic evolutionary questions such as the nature of individually-consistent hormonal traits are still unanswered. The research proposed here embraces hormonal plasticity by using a novel reaction norm approach. Reaction norms are a gold standard in physiological and evolutionary ecology, but have rarely been applied to hormones. Glucocorticoids (GC) mediate environmental responses in many vertebrate traits. Using great tits (Parus major), I will characterize individual GC phenotypes by quantifying GC components and their reaction norms across environmental gradients. These will be assessed repeatedly to test for repeatability, while field studies will explore fitness relationships. I will address four hypotheses: 1) Individuals differ in GC flexibility; 2) Individuals show repeatable GC responses across different contexts and seasons; 3) GCs are related to reproductive success; and 4) GCs modulate reproductive performance. I will quantify GCs at baseline, after capture-restraint and after negative feedback induction in captivity. I will also assess variation in baseline GC along temperature and workload gradients. I will conduct these tests in non-breeding and breeding seasons to calculate repeatability for GC components. I will then adapt these methods to the field, to investigate how GC flexibility correlates with fitness. Finally, I will impose an environmental challenge during the chick-rearing stage by increasing workload to assess GCs and performance. With this novel approach I aim to advance evolutionary endocrinology by identifying individual hormonal characteristics that are repeatable and fitness-relevant. This research represents a topic of high relevance for science and the public and will provide outstanding academic training to an experienced researcher.

Keywords: glucocorticoids,reaction norms,hpa axis,global change,avian ecology and evolution
Cholesterol and Sugar Uptake Mechanisms (CSUMECH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1499848.0
EU funding (EUR): 1499848.0
Participants: 1
Project status: CLOSED

Cardiovascular disease, diabetes and cancer have a dramatic impact on modern society, and in great part are related to uptake of cholesterol and sugar. We still know surprisingly little about the molecular details of the processes that goes on in this essential part of human basic metabolism. This application addresses cholesterol and sugar transport and aim to elucidate the molecular mechanism of cholesterol and sugar uptake in humans. It moves the frontiers of the field by shifting the focus to in vitro work allowing hitherto untried structural and biochemical experiments to be performed. Cholesterol uptake from the intestine is mediated by the membrane protein NPC1L1. Despite extensive research, the molecular mechanism of NPC1L1-dependent cholesterol uptake still remains largely unknown. Facilitated sugar transport in humans is made possible by sugar transporters called GLUTs and SWEETs, and every cell possesses these sugar transport systems. For all these uptake systems structural information is sorely lacking to address important mechanistic questions to help elucidate their molecular mechanism. I will address this using a complementary set of methods founded in macromolecular crystallography and electron microscopy to determine the 3-dimensional structures of key players in these uptake systems. My unpublished preliminary results have established the feasibility of this approach. This will be followed up by biochemical characterization of the molecular mechanism in vitro and in silico. This high risk/high reward membrane protein proposal could lead to a breakthrough in how we approach human biochemical pathways that are linked to trans-membrane transport. An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general public health, and furthermore this proposal will help to uncover general principles of endocytotic uptake and facilitated diffusion systems at the molecular level.

Keywords: membrane protein structure,crystallography,single particle em,cholesterol uptake mechanism,sugar uptake mechanism
Thrust Reverser Unit flow visualization (TRUflow)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Switzerland,United Kingdom,United Kingdom
Call: Development of Measurement Techniques for Visualisation and Evaluation of Reverse Flow Interactions with Fan (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-05-01
End date: 2022-10-31
Duration (months): 42.0
Total project cost (EUR): 2514805.0
EU funding (EUR): 2514805.0
Participants: 4
Project status: SIGNED

Thrust Reverser Unit flow visualization – TRUflow will develop novel measurement techniques for the visualization and evaluation of reverse flow interactions with fan aerodynamics in short slim engine nacelle designs applicable to the next generation of ultra-high bypass ratio (UHBR) aero engines. UHBR engine architectures offer increased propulsive efficiency through operation at reduced specific thrust, enabled by increased engine diameter. This poses challenges, both in terms of the aerodynamics of the isolated nacelle, and the potential for interference effects between the different engine components such as the Thrust Reverser Unit (TRU). TRUflow will initially investigate several visualization techniques using a static demonstrator as a workbench for these measurement techniques. Following this investigation, a Wind Tunnel Test (WTT) will be carried out aiming to prove the efficacy of these techniques. In parallel, TRUflow will develop and verify a numerical methodology for the evaluation of TRU cascades. The numerical and experimental data will be fused together to generate a reduced order model of the TRU unit suitable for design.
The Whole Sun Project: Untangling the complex physical mechanisms behind our eruptive star and its twins (WHOLE SUN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Spain,Norway,Greece,France,United Kingdom
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-05-01
End date: 2026-04-30
Duration (months): 84.0
Total project cost (EUR): 11238375.0
EU funding (EUR): 11238375.0
Participants: 6
Project status: SIGNED

We live around an active magnetic star, our Sun, that has a direct impact on our technological society through its variability and eruptive behaviour. Despite decades of intense research, fundamental questions such as How does the Sun work? Why does it possess a magnetic cycle and a dynamic hot atmosphere and how they are interrelated? remain mostly unanswered. In the Whole Sun project, we aim at tackling these key questions as a coherent whole for the first time. For too many years, the Sun has been split into internal and external solar physics topics lacking a global integrated view of its complex plasma dynamics. For instance, dynamo simulations seeking to answer the origin of the magnetic field and of its cyclic behaviour neglect surface physics and the existence of sunspots and likewise surface models often assume the magnetic field as a given input without the detailed knowledge of the nonlinear interplay between convection, rotation and magnetic fields in the Sun’s outer envelope. The time has come to gather European world leading solar/stellar physicists to build a deeper understanding of our star and to extend it to its twins. To do so many bottlenecks must be addressed: highly disparate spatial and temporal scales, physical interfaces of all solar layers, complex microphysics and global effects, strong dynamics and how parameters such as star’s metallicity, mass and rotation influence the outcome. By gathering physicists from each side of the solar surface we aim at tackling these challenging, beyond the state-of-the-art problems, by developing a deep theoretical understanding of our star and of its analogues and by building the most advanced multi-resolution solar code in order to jointly address global/macrophysics and local/microphysics aspects of the solar dynamics. The advent of Exa-scale computers makes such a challenge within our reach as do modern analysis methods to interpret observations and 4-D data cube that the project will produce or access.

Keywords: solar physics,dynamo,magnetohydrodynamics mhd,plasma physics,solar activity,solar stellar connection
Dietary shaping of the early life metabolome and its role in healthy lung and brain development (DEFEND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Denmark,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499952.0
EU funding (EUR): 1392678.25
Participants: 2
Project status: SIGNED

Asthma and behavioral problems related to neurodevelopmental delay such as ADHD and autism are common childhood disorder with lack of insight in disease mechanisms and no preventive measures, which is an unmet medical and societal need. In the Danish COPSAC mother-child cohort, I showed in two randomized trials that pregnancy supplements with n-3 long-chained polyunsaturated fatty acids (n-3 LCPUFA) and high-dose vitamin D reduced offspring asthma risk, improved cognitive scores and accelerated language and milestone achievement, which was replicated in the American VDAART vitamin D trial. This holds the promise for primary prevention but establishing underlying biochemical mechanisms and effect modification by maternal and early life diet and host genetics remains to achieve a personalized preventive strategy targeting supplements only to those women, whose offspring will benefit from it. This research project aims to understand how dietary supplements and diet in pregnancy and early life shapes the child’s metabolism and how this is linked to asthma and neurodevelopment, using longitudinal untargeted and targeted metabolomics profiles from more than 1,500 mother-child pairs in COPSAC and VDAART, detailed data on maternal and infant diet, the early life exposome, and genetics and genomics data. The objective is to identify metabolites and biochemical pathways of importance for asthma and neurodevelopment, focusing on n-3/n-6 LCPUFAs, sphingolipids and tryptophan, with the ultimate goal to achieve healthy lung and brain development through personalized diet interventions during pregnancy. The transdisciplinary study group lead by the applicant consisting of MDs with pediatric, respiratory and psychiatric expertise, wet and dry lab metabolomics experts and bioinformaticians will bridge basic and clinical sciences in an international collaboration between COPSAC, Denmark, and VDAART at Harvard Medical School, US.

Keywords: asthma,child,diet,long chained polyunsaturated fatty acids,metabolomics,neurodevelopment,pregnancy,prevention,vitamin d