Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Performance, Cloud and Symbolic Computing in Big-Data problems applied to mathematical modeling of Comparative Genomics (MR.SYMBIOMATH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Austria,Austria,Spain,Germany,Spain
Call:  (FP7-PEOPLE-2012-IAPP, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 2616332.63
EU funding (EUR): 2616332.63
Participants: 6
Project status: CLOSED

Large scale genomics projects exploiting high throughput leading technology have produced and continue to produce massive data sets with exponential growing rates. So far, only a small part of this data can be abstracted, managed and processed, giving an incomplete understanding of the biological process being observed. The lack of processing power is a bottle neck in acquiring results. Comparative genomics is a good example since it includes all the ingredients: huge and ever growing datasets, complex applications that demands large computational resources and new mathematical and statistical models for analysing and synthetizing genomic information. A promising approach to address such massive data sets is the creation of new computer software that makes effective use of parallel processing. This proposal pursues the linking of different research domains to come up with a coordinated multi-disciplinary approach in the development of tools targeting Big-Data and computationally intensive scientific applications. Generic solutions for Big-Data storage, management, distribution, processing and final analysis will be developed. These solutions will target a broad range of scientific applications, in concrete, as proof-of-concept they will be implemented in the ‘Comparative Genomics’ field of bioinformatics and biomedical domains. Applications such as the detection of main evolutionary events, new comparative genomics’ models that can be evaluated experimentally, for inter-species evolutionary distance, the composition of the k-mers dictionaries for each specie, or customising symbolic computing methods to determine the consensus tree from a sequence of trees with application in multiple sequence alignments, phylogenetic studies, clustering algorithms, etc. present in diverse fields of bioinformatics, from NGS-DNA assembly to gene-expression, all of them well suited applications to apply HPC-CC approaches and with high and attractive potential for commercialization.

Keywords: big-data,comparative genomics,evolution events,phylogenetic trees,high performance computing,cloud computing,symbolic computing,visualization
From math to ward: mathematical models in the doctor's hand (MATH2WARD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland,Italy
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-05-01
End date: 2014-04-30
Duration (months): 12.0
Total project cost (EUR): 167983.2
EU funding (EUR): 149785.0
Participants: 3
Project status: CLOSED

The MATH2WARD PoC intends to investigate the commercial feasibility of a light smart platform for everyday clinical practice which, upon receiving and elaborating a patient’s characteristics from classical medical equipment, can provide in real-time quantitative output based on numerical simulation, improving clinicians’ knowledge and driving their decisions. The mathematical engine can run algorithms very quickly and provide elaborations of multiple and meaningful inputs. The domain of intervention is that of cardiovascular diseases and the final users are cardiologists, cardiovascular surgeons or, more generally, clinicians dealing with subjects affected by cardiovascular pathologies. The potential benefits include: helping clinicians make decisions on diagnosis - i.e. in detecting surgery necessity; improving the quality of communication (clinician-clinician and clinician-patients) thanks to clear and meaningful visualisations; enhancing knowledge management. Thus the products derived from the platform could speed up and ameliorate the necessary time and expenses for diagnosis, therefore allowing to reduce the costs of hospitalisation and treatments. The preliminary analysis shows that the products deriving from the platform (a SW and a device with integrated SW) could have a significant impact on the industrial market. The PoC activities will further investigate the suitable commercialisation processes (i.e. direct industrialization or licensing for outsourced development, direct commercialization, and/or joint venture with clinical devices manufacturers). It will further define innovative and distinctive characteristics of the products through technology intelligence, after validation (testing in clinical environment and assessment by stakeholders). It will better define an IPR protection strategy (i.e. copyright for SW and patent for the device), and allow agreements with industrial/financial partners for the products industrialization and commercialization.

Keywords: 227058
Novel organometallic anticancer compounds (ORGANOMET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2014-04-30
Duration (months): 16.0
Total project cost (EUR): 156795.96
EU funding (EUR): 149559.0
Participants: 1
Project status: CLOSED

Currently the most widely used drugs for the treatment of cancer are platinum compounds, used in nearly 50% of all chemotherapeutic regimens. However the platinums can suffer from problems of resistance, a limited spectrum of activity, and side-effects. Hence new agents with new mechanisms of action are urgently needed. We have discovered novel organometallic osmium and iridium compounds with more potent anticancer activity and unique mechanisms of action. Initial work on an osmium compound has demonstrated promising activity against colorectal cancer without toxic side-effects, providing an opportunity to satisfy unmet clinical needs. The ERC PoC funding will allow the discovery phase to be advanced, to turn hits into leads by establishing and validating target sites, and elucidating mechanisms of action. The techniques employed to achieve this PoC will combine high throughput proteomcs/genomics approaches with image analysis of cancer cell morphology in a mathematical analysis to determine the mechanism of action. Data from cancer models will validate the efficacy of the most active compounds. This portfolio of data, together with desk research on potential patient populations, will provide a strong basis for attracting a partner in the next stage of preclinical development.

Keywords: 247450
Datacenter Monitoring for Improving Insight and Efficiency (DAMON)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Belgium
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-11-01
End date: 2013-10-31
Duration (months): 12.0
Total project cost (EUR): 160800.0
EU funding (EUR): 149880.0
Participants: 1
Project status: CLOSED

We have developed a novel monitoring mechanism for the datacenter that has the potential to be a holistic monitoring solution that will help optimize day-to-day operations, identify business opportunities, reduce operational expenses, and reduce carbon footprint. The key idea is to monitor the types and the latencies of the requests coming in into the datacenter, and correlate the request stream with the hardware resources used in the datacenter. Although conceptually simple, this monitoring solution provides a wealth of invaluable information and creates a number of opportunities, both at the technical and business side, which no other existing monitoring solution offers. In this project, we will study the broader market, for where to exploit the technology, ranging from web application companies, to datacenter and cloud providers, to datacenter owners; define business needs and requirements; evaluate the technology across market segments with friendly customers; and develop an IP portfolio and business plan. The end result of the project is to create the essential conditions to start the early commercial stage of this idea.

Keywords: 259295
A novel mechanism to regulate gene expression in the brain (DD-PD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Sweden
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-11-01
End date: 2013-10-31
Duration (months): 12.0
Total project cost (EUR): 166510.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Development of advanced therapeutics based on non-small molecule drugs for brain diseases is an area of intense research. Experimental work using viral vector-mediated in vivo gene therapy showed great potential as a competitive therapeutic strategy for clinical use in neurodegenerative diseases. AAV vectors are now in early clinical trials stage for treatment of Parkinson’s disease. Although it is deemed very important to have controlled expression in the brain, none of the currently tested strategies have implemented an approach that can be exogenously controlled. Regulation of the therapeutic intervention is important not only for safety reasons but has important implications for tuning the delivery of the therapeutic molecule to the individual needs of the patients, i.e., personalizing their treatment. The core of this proof-of-concept application is to develop a novel gene regulation system as a product for clinical use in patients with Parkinson’s disease. The applicant has assembled a strong team of experts that can take this exciting idea that has spun out of his ERC-funded research to an early business strategy and bridge to commercialization. The work will include filing of new IP, a proactive use of novelty search, formation of a dedicated start-up company for handling the new IPR as well as in-licensing of related IP, and sketching a path towards commercialization via obtaining regulatory authorization, investigation of strategies for large-scale production of the product.

Keywords: 242932
Lubricated scaffolds for tissue engineering (SCAFFOLUBE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Israel
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-03-01
End date: 2014-02-28
Duration (months): 12.0
Total project cost (EUR): 166401.6
EU funding (EUR): 149999.76
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is a painful joint disorder affecting millions of sufferers worldwide, and occurs through formation oflesions followed by degradation of the articular cartilage layer coating the major joints. Repair of such lesions via tissue engineering has been one of the most promising directions for alleviating OA. The rationale behind this is that the cartilage lesions regenerate after implantation of a scaffolding matrix incorporating desired cell types. Limited clinical success partially originated from the lack of suitable interfacial properties of the scaffolds. We have applied recently revealed concepts on hydration interactions (on some of which we hold a patent), which, we believe, will lead to a significant advance in scaffold-based treatment of cartilage lesions. This applies in particular to the development of scaffolds with modified interfacial properties, which are essential for repairs of large lesions. This is realized by fabricating suitable scaffolds with suitable additives, whose properties form an integral part of our associated ERC project. This Proof of Concept project,which thus ties in closely with our ERC project, consists of several workpackages. An integral part of the plan of work will establish proof of the feasibility of the idea through modification, characterization and mechanical fine-tuning of scaffolds for cartilage compatibility. The other workpackages, which are at the heart of this project, will examine the prospects of commercializing such scaffolds for clinical applications, via multifaceted market studies; identification of possible partners;and development of an appropriate business model.

Keywords: 247305
Cognitive Training Method for Enhancing Semantic Processing (PROCOG)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Israel
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 165560.0
EU funding (EUR): 149791.0
Participants: 1
Project status: CLOSED

The "Word Game" is an innovative cognitive training program for improving linguistic comprehension abilities. The novel training method was developed as part of the INSPIRE ERC research project, and it is based on theories and empirical findings that describe the role of the brain's right hemisphere in semantic processing. A controlled experiment showed that after ten training sessions, on a seemingly fun and challenging computer game, healthy adults showed improved semantic performance transferred to tasks that were not trained directly. ProCog’s objective is to take the first steps in the commercialization of Word Game as an online training application. The growing market of software-based brain enhancement tools does not offer any solution for enhancing semantic functions in healthy adults, though research shows these abilities are essential for language comprehension, that they decline with age, and are sub-optimal among many. Using Word Game will benefit individuals' thinking and comprehension abilities, allowing them to better understand conversations and texts in daily life, draw inferences from partial verbal information, and use language creatively by “connecting the dots” in unusual ways. These benefits go beyond the individual gain of end-users, and could impact intelligence analysis, scholarship, art, and the quality of life of the elderly. All these populations constitute the consumer segments targeted in ProCog. To take Word Game from the lab to the world, the ProCog PoC will: Create a business plan and marketing strategy based on market analysis and evaluation of possible collaborations with existing cognitive training providers; Peruse legal aspects of IPR protection; Implement marketing activities and links with investors and potential partners; and Finalize the development of a web-based platform with an English version of Word Game. Thus, ProCog’s outcome will provide a new arsenal for enhancing the capabilities of the associative mind.

Keywords: 200512
Mapping Culture (GlamMap): Scalability of insightful metadata visualisation for the GLAM (cultural heritage) sector (GLAMMAP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-09-01
End date: 2014-08-31
Duration (months): 12.0
Total project cost (EUR): 149999.85
EU funding (EUR): 149999.85
Participants: 1
Project status: CLOSED

Mapping Culture (GlamMap) verifies scalability, societal relevance, innovation and commercialisation potential of a metadata visualisation tool developed in a pilot within the ERC project ‘Tarski’s Revolution’ (TRANH). We want to propose a visualisation software package aimed at the GLAM (cultural heritage) industry sector. The software we envisage (GlamMap) will enable GLAM actors to provide web-based visualisations of their collections of books, paintings or movies in a flexible, insightful, cost-effective and user-friendly way to the benefit of various kinds of users, including both researchers and the public at large. We shall build a visualisation prototype (small-scale technical validation) of GlamMap integrating a data harvester. Our team will include two programmers and a technical supervisor coordinated by the applicant (PI), possibly aided by a student assistant. The data harvester benchmarking will rely on the data manually collected for the original ERC project pilot. Market research to investigate competitiveness of our software with respect to alternative solutions will be conducted working in partnership with members of the GLAM industry sector. Market research for GlamMap will also include investigating viability of a (open source) Red Hat-style business model.

Keywords: 203194
A double tilt cryoholder for ultra high resolution transmission electron microscopy at low temperatures (COOL-HRTEM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-11-01
End date: 2013-12-31
Duration (months): 14.0
Total project cost (EUR): 149953.0
EU funding (EUR): 149953.0
Participants: 1
Project status: CLOSED

The transmission electron microscope (TEM) is an essential instrument facilitating studies of the nanoscale material structure at sub-1Å resolution for R&D in the area of materials science, nanoscience and nanotechnology. In order to access the highly relevant temperature range between 77 K and room temperature, special specimen cryoholders need to be used that allow for a double tilt of the specimen under study. However, it is impossible to make images with sub-1Å resolution with the existing commercial double-tilt cryoholders. This is due to effects of thermal gradient-induced drift and mechanical vibrations. As part of my ERC Advanced Grant I have pioneered single-tilt cryoholders with electrical feedthroughs that largely overcome these problems, resulting in sub-1Å high resolution TEM at ~100 K in at least 15% of the images that are recorded. With this proposal, I wish to take these advances towards a proof of concept for a double-tilt cryoholder that allows sub-1Å high-resolution TEM in at least 80% of the recordings at any temperature between 77 K and 300 K and represents a user-friendly standard technique with commercial potential. I plan to make these holders available to researchers at similar price levels of currently available holders. Based on my acknowledged track record in developing microscopy innovations, I have drafted a plan to prototype this invention. I will seek an industrial partner to perform a design cycle for real production, and next produce the holders.

Keywords: 267922
Development of advanced catalysts for PEMFC automotive applications (NANO-CAT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: France,Spain,Belgium,European organisations area,United Kingdom,Germany,Sweden
Call:  (FCH-JU-2012-1, 2012)
Start date: 2013-05-01
End date: 2017-01-31
Duration (months): 45.0
Total project cost (EUR): 4394331.0
EU funding (EUR): 2418439.0
Participants: 8
Project status: CLOSED

Many efforts have been put on the reduction of the Pt loading but nowadays a threshold seems to be obtained. Because the kinetics of the Hydrogen Oxidation Reaction is very fast on Pt, it is possible to use MEA with a Pt loading as low as 35 µgPt/cm-2 without any effect on the voltage loss when such an anode is used in front of a well working cathode. But, the Oxygen Reduction Reaction kinetics is not so fast which is the limiting step concerning the electrochemical processes in a PEMFC. For that raison, the decrease of the Pt loading is now encountering a plateau. Nano-CAT will propose alternatives to the use of pure Pt as catalyst and promote Pt alloys or even Pt-free innovative catalyst structures with a good activity and enhanced lifetime due to a better resistance to degradation. Nano-CAT will thus develop novel Pt-free catalysts (called bioinspired catalysts) and explore the route of nanostructured Pt alloys with very low Pt content. Catalysts are chemical species on which the electrochemical reactions are accelerated. PEMFC uses heterogeneous catalysis meaning the catalyst needs to be supported on a material in a solid phase (catalyst support). Nano-CAT will focus on the development of new supports with 2 promising sets of solutions: functionalized Carbon NanoTubes and conductive carbon-free Metal Oxide. These supports offering a better resistance towards degradation than the carbon black commonly used will address the issue of the support degradation and the MEA lifetime. Nano-CAT will follow two routes, one low risk to ensure demonstration of the use of Pt alloys on new resistant supports and one high risk route to evaluate the feasibility of Pt-free MEA based on the use of bioinspired catalysts. Finally, Nano-CAT addresses all technical issues leading to the industrialization of the project outcomes for automotive application by the development of high quality manufacturing methods of complete MEAs required to maintain high power density and efficiency.

Keywords: catalyst,support,bio-inspired,mox,nanotubes,carbon nanotubes,pilot line,meas,short stack,harmonization of testing procedure,simulation,nanocharacterization