Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Depicting the richest source of pathogen linked miscellaneous gene expression in orphan crops by Nanopore. (OCNANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-09-07
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Modern agriculture is dominated by crops noticeable for intense food supply leaving behind a class of neglected or orphan crops. Relatively poorly studied orphan crops have the potential to diversify the human diet, increase agricultural food productivity levels and enable more sustainable and resilient agro- and horti-food systems. Here, we focus on two such crops-Piper nigrum (black pepper) the most important spice traded internationally and Piper colubrinum, a wild relative of black pepper introduced from Brazil, which is the only known source of resistance to diseases such as foot rot or quick wilt caused by an Oomycete Phytophthora capsici. Negligible genome sequence data exists for either species. Although agricultural practices for making P. nigrum resistant to this Oomycete by interspecific hybridization with P.colubrinum are well known, no effective strategies have been generated yet. The exact reason behind the resistance of P.colubrinum is not yet understood, thus leaving open a fertile area of investigation.With this background, OCNANO aims to reveal the basis of pathogen resistance that distinguish resistant from susceptible species of Piper. We will employ Oxford nanopore MinION technology to address this issue with three specific objectives:(1) Annotate the transcriptomes of P.nigrum and P. colubrinum; (2) Identify pathogen gene expression during infection using a capture array; (3) Comparative analysis of P. nigrum and P. colubrinum gene expression during infection. Innovative strategies like nanopore in combination with other sequencing approaches can transform annotation and enable the richest understanding of gene expression during pathogen attack. Research progressing towards the rescue of such orphan crops from their environmental stresses, by applying leading edge technologies, can further enhance crop productivity, food security, knowledge based economy and society and contribute to the achievement of several UN Sustainable Development Goals.

Keywords: rna seq,nanopore,piper,rna methylation,polyadenylation,phytophthora capsici
Information structures in consumer markets (INSTRUCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 1221744.0
EU funding (EUR): 443348.65
Participants: 2
Project status: SIGNED

Information flows are fundamental to how well markets work for consumers and firms. Consumers get different deals depending on (a) how much they know about the offerings of different firms and, conversely, (b) how much firms know about consumer preferences. The internet is transforming both (a) and (b), allowing consuInformation flows are fundamental to how well markets work for consumers and firms. Consumers get different deals depending on (a) how much they know about the offerings of different firms and, conversely, (b) how much firms know about consumer preferences. The internet is transforming both (a) and (b), allowing consumers to discover and evaluate products with greater ease and enabling firms to personalise prices and target their advertising. Economic understanding currently lags behind what is needed for robust policy formulation in the areas of consumer privacy, price discrimination, and the costs of search and advertising. This project aims to fill that gap. How does the structure of information in consumer markets affect market performance, and which kinds of information should be stimulated or controlled? I propose four lines of enquiry to address this over-arching theme: (1) to develop innovative modeling techniques to understand how the structure of information about consumer preferences (possessed by firms and by consumers themselves) affects overall surplus and how that surplus is divided between firms and consumers; (2) to develop methods to study how the structure of consideration sets (i.e., the set of firms a consumer is able or willing to consider for her purchase) affects market outcomes; (3) to analyse how the information channels of advertising by firms and search by consumers interact and which is more important for the efficient functioning of markets, and (4) to investigate which aspects of their preferences consumers are willing to share with firms and thereby understand better how to solve difficult but important pricing problems.
Strengthening joint programming in Europe (ERA-LEARN 2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Italy,Austria,Germany,Norway,Finland,France,United Kingdom,United Kingdom
Call: Towards joint programming under Horizon 2020 (H2020-INSO-2014, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 3199312.0
EU funding (EUR): 3199312.0
Participants: 11
Project status: CLOSED

Building on the ERA-LEARN, NETWATCH & JPIs To Co Work predecessor projects ERA-LEARN 2020 will provide an integrated framework to make P2P more efficient and effective and support national and regional funding organisations in the preparation, implementation and monitoring of joint actions. ERA-LEARN 2020 will increase mutual learning within the P2P community and will thereby support the implementation of streamlined mechanisms. Useful input will be provided towards the analysis and possible future development of P2P formats. ERA-LEARN 2020 will highlight synergies between different forms of national/regional programme coordination and facilitate high-level analysis of P2P policy-related issues. It will provide tools for analysis and communication formats for supporting future developments of transnational programme coordination. The ERA-LEARN 2020 team is highly qualified & complementary with national authorities and experts for analysis with many years experience of P2P at both the operational and policy levels. ERA-LEARN 2020 will: 1. provide a web-based information, learning and support platform for P2P to avoid duplication of efforts; 2. support the ongoing optimisation of P2P networks by providing a toolbox for the wider activities of joint programming, particularly the JPIs, Art.185 and ERA-NET Cofund instrument, as well as their associated impacts; 3. implement a systematic process for monitoring & impact assessment of P2P networks, including their impacts at both the policy, programme and co-funded RTD project-level; 4. assess and benchmark current approaches to alignment and explore options for new modalities to better align national and/or regional activities under common research agendas; 5. implement an annual cycle of knowledge exchange aimed at increasing the impact of investment in P2P activities and exploring options to support less research intensive countries.

Keywords: public public partnerships,joint progamming,era net cofund,joint calls,alignment,assessment,monitoring,knowledge hubs
Elucidation of the evolution of post-transcriptional regulation by characterizing the cnidarian microRNA pathway (CNIDARIAMICRORNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1499587.0
EU funding (EUR): 1499587.0
Participants: 1
Project status: CLOSED

Over the past decade small RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs) have been shown to carry pivotal roles in post-transcriptional regulation and genome protection and to play an important part in various physiological processes in animals. miRNAs can be found in a very wide range of animals yet their functions were studied almost exclusively in members of the Bilateria such as insects, nematodes and vertebrates. Hence studying their function in representatives of non-bilaterian phyla such as Cnidaria (sea anemones, corals, hydras and jellyfish) is crucial for understanding the evolution of miRNAs in animals and can provide important insights into their roles in the ancient ancestor of Cnidaria and Bilateria. The sea anemone Nematostella vectensis is an excellent model for such a study since it can be grown in large numbers throughout its life cycle in the lab and because well-established genetic manipulation techniques are available for this species. Our preliminary results indicate that miRNAs in Nematostella frequently have a nearly perfect match to their messenger RNA (mRNA) targets, resulting in cleavage of the target. This mode of action is common for plant miRNAs, but is very rare in Bilateria. This finding together with my recent discovery of a Nematostella homolog of HYL1, a protein involved in miRNA biogenesis in plants, raises the exciting possibility that the miRNA pathway existed in the common ancestor of plants and animals. Here I suggest to bring together an array of advanced biochemical and genetic methods such as gene knockdown, transgenesis, high throughput sequencing and immunoprecipitation in order to obtain - for the first time - a deep understanding of the biogenesis and mechanism of action of small RNAs in Cnidaria. This will provide a novel way to understand the evolution of this important molecular pathway and to evaluate its age and ancestral form.

Keywords: microrna,post transcriptional regulation,cnidaria,evolution of gene regulation
Fodder for for HEALTHier animals and improved liveSTOCK production (HEALTHSTOCK)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

"PENTABIOL has developed and tested PROBISAN, a fermented fodder for nutrition of animals that overtakes the performance of any other fodder in the market. The most strict and unbiased product test has been undertaken on a single commercial swine farm in Spain comparing PROBISAN, DIAMOND V (the leading product in the market) and the best performing fodder ever experienced in the farm, namely PROBIO, which was a fodder specifically engineered for this farm using probiotic additives. Each fodder was used to feed during the same period of a population of 1.575 piglets (252 each fodder).PROBISAN piglets ate 3,3% less and grew 4% more than PROBIO piglets, and ate 10% less and grew 4% more than DIAMOND V piglets. Considering both effects PROBISAN offers 14% more yield than the market leader and 7,3% more yield than the best specially engineered product. Furthermore the average deviation of results with the group of 7 independent tests showed that PROBISAN is much more stable than the other fodders."

Keywords: fermented foder,sybiotic
From pills to bio-electronics: a wearable anti-inflammatory treatment for prevention of Peripheral Arterial Disease. (AuriMod)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Austria
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Peripheral Arterial Disease (PAD) is a life-threatening disease affecting 200 M people in the world (40.5 M only in EU) and represents the third cause of world cardiovascular morbidity. PAD is a chronic condition generated by the narrowing of arteries, which reduces the normal blood flow and triggers a wide range of manifestations mostly in the lower limbs, from chronic pain to critical limb ischemia. PAD’s progression can lead to chronic wounds, gangrene, amputation, and in most severe cases, death. There is no current solution able to target the broad range of symptoms and complications related to PAD. AuriMod is a wearable device for non-invasive auricular stimulation of the vagus nerve that is capable of treating all symptoms of PAD, avoiding conventional drugs’ side effects and preventing complications including chronic wounds and consequent amputations. Applied to the patient’s ear, AuriMod sends specific electrical stimulation to the auricular branches of the vagus nerve, delivering a patient-tailored therapy that will improve the quality of life of PAD patients. This Phase 1 project will mainly focus on planning further product development, verifying the current supply chain, evaluating the business model and commercialisation plan. The overall innovation project will enable to optimise AuriMod device, conduct clinical trials to validate safety and effectiveness of AuriMod-based therapy and acquire all certifications required for AuriMod’s commercialisation.

Keywords: peripheral artery disease,pain,chronic wounds,wearable,biofeedback,closed loop control,intermittent claudication,health,e health,quality of life,healthy ageing,electrical stimulation
Photoacoustic/Ultrasound Mammoscopy for evaluating screening-detected abnormalities in the breast (PAMMOTH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Switzerland,Lithuania,France,Czechia,Netherlands,United Kingdom
Call: Photonics KET 2016 (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 5105105.0
EU funding (EUR): 4352007.5
Participants: 9
Project status: CLOSED

X-ray mammography is the mainstay of breast cancer screening programs. It is estimated that between 20 - 50% of abnormal screening mammograms will prove to be negative. The paradigm in diagnosis is to establish whether a lesion is benign or malignant. All the imaging techniques conventionally used today – diagnostic x-ray, ultrasonography and magnetic resonance imaging have many limitations, leading to multiple and/or repeat imaging and often unnecessary biopsy. This leads to physical, psychological and economic burdens felt at individual, familial and societal levels. With an aging population, high incidence of breast cancer and tightening health-care budgets, there is an urgent requirement for a non-invasive method for in-depth assessment of the screening-detected lesion. In PAMMOTH we will showcase such an imager, combining photoacoustic and ultrasound imaging. With the use of quantitative image reconstruction of multi-wavelength photoacoustic data, information is gained of the vascular and oxygen status of the lesion relating to tumor physiology and function. From the ultrasound part, we derive ultrasound reflection from the lesion in a manner superior to conventional breast ultrasonography, relating to anatomic features and extent of a tumor. This information will enable the radiologist to come to a diagnosis accurately and rapidly without the use of contrast agents, without pain and discomfort to the patient, while being cost-effective and not requiring complex infrastructure. Four excellent academic groups, three dynamic SMEs, and a hospital come together with support from key stakeholders in an Advisory group, to push beyond the state-of-the-art in science and technology to achieve the PAMMOTH imager. For the SMEs, in addition to tremendous improvements in individual product lines, the new integrated diagnostic imaging instrument opens up completely new market opportunities. We expect PAMMOTH to have a strong economic and clinical impact.

Keywords: breast cancer diagnosis,angiogenesis,tumor hypoxia,photoacoustic imaging,ultrasound imaging,multi modal imaging,quantitative imaging,photoacoustic spectroscopy,validation in clinical setting
Assistive Devices for the Visually Impaired and other Disabilities (Tech4Freedom 2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Spain
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 1542742.5
EU funding (EUR): 1079919.75
Participants: 1
Project status: TERMINATED

In 2010, there were 285million blind and visually impaired people in the world (a 77% increase from 161million in 2002) and that is a number that is still growing. In line with the European Disability Strategy 2010 – 2020 and to provide a technological solution to help the visually blind increase their level of security and independence, Aticser has been developing a kit of small, assistive devices controlled by our visually impaired user-friendly mobile app to help them in their daily lives. Aticser has been working with influential blind associations throughout Europe to produce the T4F Basic Kit, but we hope to improve it according to the comments and suggestions given by individuals and the blind associations that have validated the Basic Kit to produce a new and improved 2.0 Kit based on a modular approach. During our product validation, 85% of users expressed willingness to pay saying they will buy our new T4F Kit when it is on the market. We already have agreements with over 10 companies in Europe, Canada, the US, India and China who will be distributors who sell our T4F Kits to the end user (blind and visually impaired people). 80% will be sold through the distributors, such as the Spanish organisation ONCE (which is the most common way for blind people to buy assistive devices) and 20% directly through our website. We have a large potential market at a worldwide level: 99 million users = 147.960 millions of €s. Our goal for the SME Instrument project is to add functionalities to our T4F Basic Kit and to add a couple of devices to make our T4F 2.0 Kit disruptive to the existing market which so far does not include a one-stop solution like ours. Our T4F 2.0 Kit will make daily tasks easier for blind and visually impaired people and in the future, we plan to develop our products for people with other disabilities (such as Parkinson’s disease) with the help of other disability associations: AMPANS and Via Libre.

Keywords: assistive devices,european disability strategy,blind,visually impaired
Island Diversity from an Eco-evolutionary Approach (IDEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-15
End date: 2018-03-14
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The science of island biogeography is currently undergoing a huge resurgence of interest, due mainly to the advent of novel sources of data, most notably on geological dynamics, climate-driven sea-level changes, remotely sensed climate, vegetation structure and topography, and, centrally, the phylogenetic relationships among species. This has paved the way for an understanding of how island geographical dynamics shape dynamics of species diversity and the evolution of clades, but has also opened up a whole range of unanswered questions: How has the emergence of islands affected evolution in clades? How does vegetation structure and topographic complexity shape patterns of diversity? What are the roles of cross-taxon interactions in governing these processes? And how do these patterns scale from the island to the community level? In this proposal, I aim to address these unanswered questions by studying a uniquely well-defined group, the radiation of corvid birds in the Indo-Pacific. From the beginning of the project I will have access to an existing database on the spatial distribution, phylogenetic relationships, habitat associations and morphological traits for these birds. I will combine this with building databases on the topographic complexity, vegetation, and ages of the Indo-Pacific islands, and supplement these data with generating primary field data from bird sampling and drone flights. The analytical approach will be based on mixed effect model analysis, null models and simulations. The results from this research will have a broad international interest, and will help the international research community to rise to the challenge of understanding patterns of species diversity – an understand that is crucial for protecting biodiversity in a changing world.

Keywords: island biogeography,species diversity,indo pacific,birds