Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Comprehensive characterization and effective combinatorial targeting of high-grade serous ovarian cancer via single-cell analysis (HERCULES)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Finland,Sweden,Finland,France,United Kingdom
Call: Understanding disease: systems medicine (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 5994868.75
EU funding (EUR): 5994868.75
Participants: 10
Project status: CLOSED

The goal of this multidisciplinary project is to comprehensively characterise high-grade serous ovarian cancer (HGS-OvCa) at single-cell level, identify the best combination of drug combination to kill HGS-OvCa populations and commercialise a predictive biomarker kit for finding the right therapeutic regimen to the right patient. This project takes an advantage on prospectively and longitudinally collected fresh sample specimens from multiple anatomic sites of HGS-OvCa patients with metastatic disease. Fluorescence activated cell sorting and recently developed mass cytometry are used to identify subpopulations in HGS-OvCa tumors. This is followed by single-cell analysis at genetic and transcriptomics levels, and ex vivo drug screening experiments. These data will be used to establish network models to predict the most effective combinatorial treatments. The key results will be validated with existing HGS-OvCa data together with prospective and retrospective cohorts and in vivo models. The clinically most actionable treatment suggestions from our modelling efforts will be translated to HGS-OvCa patient care. Ovarian cancer kills more than 40,000 women in Europe every year due to lack of effective and long-lasting therapeutic regimens. HERCULES presents an innovative strategy to suggest effective treatments that lead to a marked decrease in ovarian cancer deaths and reduce the number of expensive but inefficient treatments. Our approach paves the way to move beyond the current trial-and-error clinical assessment of drug combinations toward more systematic prediction of the most effective drug combinations for each patient. The proposed approach will be a major breakthrough in systems medicine and will benefit individual ovarian cancer patients and the health-care system through more effective treatments, and the diagnostic and pharmaceutical industry through tools for better stratified clinical trials, and novel treatment and diagnostic modalities.

Keywords: ovarian cancer,deep sequencing,network modeling,drug screening,predictive modeling,personalized medicine
European Training Network on Visible light based Interoperability and Networking (VisIoN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Germany,Spain,Spain,Türkiye,France,France,Czechia,Czechia,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-09-01
End date: 2022-02-28
Duration (months): 54.0
Total project cost (EUR): 3752913.96
EU funding (EUR): 3752913.96
Participants: 16
Project status: CLOSED

New generations of LEDs have attractive features such as a long life expectancy, lower power consumption and reduced heat dissipation. In line with governmental plans worldwide, it is predicted that LEDs will be the ultimate light source in the near future. Besides indoor illumination, LEDs are being widely used in street lighting, traffic signs, advertising displays, transportation, etc. Visible light communication (VLC) is one of the most promising current areas of research with a significant potential for high-impact results, and successful outcomes might revolutionize utilization of LEDs for modern infrastructures to add novel functionalities in addition to illumination. VLC has been proposed for smart homes and streets, manufacturing and medical environments for increased data security and reduced interference, or a two-way vehicle-to-vehicle and vehicle-to-roadside infrastructure communications as part of the emerging intelligent transportation systems for increasing road safety. The proposed “European Training Network on Visible-light based Interoperability and Networking (VisIon)” aims to train a new generation of early-stage researchers (ESRs) in the emerging area of VLC. Through research on co-supervised individual projects focusing on selected applications, VisIon will make significant contributions to the fundamental scientific understanding and technical knowhow. Targeted application areas include indoor and outdoor VLC access, smart transportation, and medical and manufacturing environments. In addition to technical training through PhD courses, dedicated tutorials and workshops organized by the Network, the ESRs will benefit from a wide range of complementary non-technical training activities such as entrepreneurship, authoring scientific papers/patents, dissemination, etc. The participation of industrial partners will further promote research training with commercialisation perspectives enabling ESRs to fully integrate theory with hands-on practice.

Keywords: visible light communications,smart cities and homes,smart transportation,internet of things,camera communication,optical wireless communications,oled,lighting
Translation Under Constraint: Censorship in the Islamic Republic of Iran (sTUCk)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-02
End date: 2022-10-01
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The indispensable status of translation and translators in Iran, the availability of multiple translations of the same works, and the strict censorship imposed by the government on translators make the Iranian situation a promising object of translational research, well beyond its areal provenance. The proposed research will try to describe the main characteristics of the particular field of literary translation in Iran by analyzing the dynamics between different role players competing with each other in this field. It will then try to explore the true nature of limitations and constraints that Iranian translators are exposed to and discover different strategies that they use in practice to deal with these limitations and constraints. To this end, an English novel and its multiple Persian translations will be carefully examined in the light of information obtained from interviews that will be conducted with the Iranian translators of the novel.

Keywords: translation studies,censorship,iran,persian,bourdieu s sociological field theory
Redefining geothermal fluid properties at extreme conditions to optimize future geothermal energy extraction (REFLECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Ukraine,Iceland,Spain,Italy,Germany,Germany,Germany,Belgium,Türkiye,Bulgaria,Greece,Croatia,Hungary,Poland,Romania,Slovenia,Switzerland,Türkiye,Hungary,Norway,France,Czechia,Netherlands,Netherlands,Portugal,United Kingdom
Call: Optimising manufacturing and system operation (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 4992761.25
EU funding (EUR): 4992761.25
Participants: 28
Project status: SIGNED

The efficiency of geothermal utilisation depends heavily upon the behaviour of the fluids that transfer heat between the geosphere and the engineered components of a power plant. Chemical or physical processes such as precipitation, corrosion, or degassing occur as pressure and temperature change with serious consequences for power plant operations and project economics. Currently, there are no standard solutions for operators to deal with these challenges. The aim of REFLECT is to avoid the problems related to fluid chemistry rather than treat them. This requires accurate predictions and thus a thorough knowledge of the physical and chemical properties of the fluids throughout the geothermal loop. These properties are often only poorly defined, as in situ sampling as well as measurements at extreme conditions are hardly possible to date. As a consequence, large uncertainties in current model predictions prevail, which will be tackled in REFLECT by collecting new, high quality data in critical areas. The proposed approach includes advanced fluid sampling techniques, the measurement of fluid properties at in situ conditions, and the exact determination of key parameters controlling precipitation and corrosion processes. The sampled fluids and measured fluid properties cover a large range of salinity and temperature, including those from enhanced and super-hot geothermal systems. The data obtained will be implemented in a European geothermal fluid atlas and in predictive models that both ultimately allow to adjust operational conditions and power plant layout to prevent unwanted reactions before they occur. That way, recommendations can be derived on how to best operate geothermal systems for sustainable and reliable electricity generation, advancing from an experience-based to a knowledge-based approach.

Keywords: high temperature,salinity fluids,thermodynamic,kinetic,thermophysical fluid properties,mineral solubility,silica,radioactive scales,extremophile bacteria,dissolved organics,fluid sampling
Raw material up-cycling for circular PV (Ramp-PV)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 1003500.0
EU funding (EUR): 700000.0
Participants: 1
Project status: CLOSED

Worldwide urgent action is needed to reduce carbon emissions and mitigate the consequences of climate change. French deeptech startup ROSI is committed to a circular economy of Photovoltaics (PV), which is decisive to render PV sustainable and to re-capture the PV value chain for Europe. Presently, several high value raw materials composing PV modules, mainly silicon and silver, which are produced through high energy consuming and CO2 emission processes, suffer great value loss, because: 1. Sawing process to obtain silicon wafers from silicon ingots discards >40% of silicon in forms of nano/micrometer particles, disposed as industrial waste; 2. No valorization of high-value raw materials such as silicon and silver in end-of-life (EOL) PV modules is carried out. The proprietary technological innovations and industrial know-how of ROSI lead to a full valorization of the raw materials from PV-waste, including: 1. Reconditioning of silicon from PV-waste for reintegration into various industries including PV, electronics, and silicone; 2. Non-destructive extraction of silver through non-toxic, low-cost and high yield process. For fast and high-quality innovation deployment, ROSI positions itself as an operator carrying out recycling activities of PV-waste in the value chain. Its realization through co-investment with industrial partners into Joint-Ventures (JV) is the scalability booster. The global development strategy of ROSI is based on construction of a series of PV-waste upcycling sites and carrying out of continuous RDTI (Research, development, technology, innovation) activities to maximize the added value of upcycled raw materials. The roadmap implementation will contribute directly to EU Green Deal and sustainability goals, as well as to the recovery of European sovereignty on the PV and raw materials value chain. The vision of ROSI is to become global-leader in circular economy of PV in 5-10 years – a high-risk and courageous vision!

Keywords: circular economy,raw materials,recycling,green deal,green recovery,silicon
Electrochemical Oxidation in the Recirculating Aquaculture Systems Industry (ELOXIRAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ELOXIRAS is an innovative water treatment concept specially developed to improve the productivity and environmental impact of marine RAS used by the exponentially growing aquaculture industry. Worldwide aquaculture sector is a market with an annual average growth of 10%. At European countries the aquaculture industry production is about 1.26 Mt/year. Aquaculture sector is a successful business opportunity The economic feasibility of inland hatchery aquaculture activities requires high biomass culture densities (kg species /m3 of water). Recirculating Aquaculture Systems (RAS) are emerging as the preferred technology to provide adequate culture water quality in hatchery activities. RAS production within EU is conservatively estimated in 0.029 Mt/year with a market value of 175 M€/year and an average growing rate of 14%/year. RAS industry is mainly established in The Netherlands and Denmark with raising interest in other European countries, for example Spain. ELOXIRAS is an innovative treatment of the culture water from marine RAS hatcheries, which is based on electrochemical oxidation technology. The novelty respect to the main competitors is related to: - High efficiency and removal of all key pollutants, including bacteria and virus. - Compact and modular design. - Reduction of water and energy requirements. - Easy to operate with adaptable capacity to required productivity. The introduction of ELOXIRAS improves the annual benefits and/or the environmental impact of the marine RAS equipped with existing competitor solution (biofilter+ozone). Thus, the introduction of this process into the actual aquaculture industry constitutes an advantaged business opportunity. The main objective of the present proposal (phase 1) is the determination of the ELOXIRAS technological and economic feasibility. After checking its feasibility a ELOXIRAS prototype will be developed in order to conduct several demonstration activities (phase 2)

Keywords: recirculating aquaculture systems industry,water savings,productivity,competitiveness
Biomacromolecules from municipal solid bio-waste fractions and fish waste for high added value applications. (DAFIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Israel,Norway,Belgium,Türkiye,France,France,Denmark,Portugal,United Kingdom
Call: Bioconversion of non-agricultural waste into biomolecules for industrial applications (H2020-NMBP-BIO-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 6430196.25
EU funding (EUR): 6430196.25
Participants: 17
Project status: CLOSED

Municipal solids waste (MSW) are collected by municipalities and represents more than 500 kg/capita (EU-27 average), 300 million tonnes overall every year in the EU-32. Currently, approximately 50% of this volume is landfilled. More than 1.3 million tonnes of Marine rest raw material (MRRM) are generated in Europe each year. Some countries, such as Norway and Denmark, have traditionally for animal feed. It will therefore be a challenge for the industry to develop methods to turn fish viscera and skin, currently considered as undesirable raw materials for hydrolysis and human consumption, into profitable products. DAFIA will exploit MSW and MRRM as feedstocks for high value products. The parallel exploitation of the two feedstocks may create synergies. This expertise will be utilised in process development from MSW, while at the same time, new added-value products may be identified from both feed stocks. The main objective of the DAFIA project is to explore the conversion routes of municipal solid waste (MSW), and marine rest raw-materials (MRRM) from the fish processing industries, to obtain high added value products, i.e. flame retardants, edible/barrier coatings and chemical building blocks (dicarboxylic acids and diamine) to produce polyamides and polyesters for a wide range industrial applications. Different value-chains and products will be selected and explored based on the potential commercial value and the technical feasibility including new microbial strains and processes for conversion of major feedstock fractions, enzymatic and chemical modifications of components isolated from the feedstock or produced in microbial processes. Up to four cost-effective molecule groups suitable for the final selected applications will be targeted (nucleic acids, dicarboxylic acids, diamines and gelatine), & two value-chains (MSW & MRRM) will be evaluated at pilot scale to reach TRL5.

Keywords: municipal solids waste,marine rest,fermentation,microbial,dicarboxylic acid,diamines,polyamides,nucleic acid,flame retardant,coating,gelatine,green chemistry
Platform Labour in Urban Spaces: Fairness, Welfare, Development (PLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Estonia,Italy,Austria,Spain,Switzerland,France,France,Netherlands,United Kingdom,Portugal
Call: Research for inclusive growth: addressing the socioeconomic effects of technological transformations (H2020-SC6-TRANSFORMATIONS-2018, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 2942377.5
EU funding (EUR): 2942377.5
Participants: 18
Project status: CLOSED

PLUS aims to address the main features of the platform economy’s impact on work, welfare and social protection through a ground-breaking trans-urban approach. The project focuses on this specific and meaningful segment of the so-called Industry 4.0 revolution because it summarizes all main opportunities and challenges for the future of work, social innovation and a fair growth. The platform economy, indeed, is emerging as a strategic sector in terms of application of digital technologies, business investments and new jobs. The project’s goal is to sketch a picture of such transformations proposing an innovative approach that identifies urban dimension as fundamental stage for measuring and evaluating social and economic impact of these innovations and for building more inclusive policies. In this way, PLUS will contribute to fill a gap both in understanding and tackling challenges posed by digitization of labour. PLUS frames a ground-breaking grid of investigation that intertwines four disruptive platforms (AirBnb, Deliveroo, Helpling and Uber) and seven European cities (Barcelona, Berlin, Bologna, Lisbon, London, Paris, Tallinn). A multi-disciplinary legal, socio-economic, political, historical approach articulated in desk analysis, field research (both qualitative and quantitative), and action research (based on communities of practice, social laboratories and pilots-cases) will be adopted in order to foster new alternative scenarios that can contribute to promote social protection, economic development and well-being in digital labour. The project valorizes the role that different stakeholders could play in promoting and balancing such transformations. A bottom-up approach and techniques of co-creation will be adopted to produce outputs directly impacting on policy-making, market and welfare: innovative typologies of contracts, a Chart for digital workers' rights, taxation and regulation guidelines, social enterprise pilots and educational patterns for new skills

Keywords: platform economy,digital labour,co creation,bottom up solutions,welfare policies,trans urban approach,social enterprise,qualitative and quantitative measuring,cohesive growth
Common Agricultural Policy Regionalised Impact - The Rural Development Dimension (CAPRI-RD)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Germany,European organisations area,Netherlands,Türkiye,Germany,Finland,Slovenia,United Kingdom,United Kingdom,Sweden
Call:  (FP7-KBBE-2008-2B, 2008)
Start date: 2009-03-01
End date: 2013-04-30
Duration (months): 50.0
Total project cost (EUR): 3030002.0
EU funding (EUR): 2295855.0
Participants: 10
Project status: CLOSED

The Common Agricultural Policy Regionalised Impact – the Rural Development Dimension (CAPRI-RD) aims to develop and apply an operational, Pan-European tool including all Candidate and Potential Candidate countries to analyse the regional impacts of all policy measures under CAP Pillar I and II across a wide range of economic, social and environmental indicators, aligned with the CMEF. CAPRI-RD’s core contains consistently linked economic models at the NUTS 2 level, the CAPRI model for agriculture, and a newly developed layer of regional CGEs. Given the importance of the EU’s agricultural trade, CAPRI includes a global agricultural market model. The project will improve price transmission modelling inside the EU market, review the implementation of de-coupled payments, and maintain the CAPRI farm type layer. Harmonised and regularly updated databases, including regional Social Accounting Matrices, act as the models’ sources. Quality management for data and results is ensured by clearly documented procedures that are partly based on statistical methods and sensitivity analysis. Spatial down-scaling algorithms will break down land use results to 1x1 km grid cells to facilitate the spatially explicit calculation of environmental impacts. During the project’s lifetime, CAPRI-RD will be improved and expanded stepwise. This will enable an annual policy impact assessment of scenarios defined by a user board comprising major stakeholders at the European level, and allow contributions to be made to the yearly DG-AGRI outlook work. Further, yearly training sessions will develop the necessary capacity in the European Research Area to successfully apply CAPRI-RD during and after the project. A Graphical User Interface (GUI) will allow the scenarios to be defined, the model to be steered, and the results to be explained through tables, graphs and maps. Dissemination activities will include the distribution of reports, model documentation, GUI, code and data via the internet.

Keywords: rural development modelling,rural development indicators,policy impact assessment,large scale economic modelling,spatial downscaling