Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ABI telerehabilitation system with high impact in patient’s wellbeing at limited cost (MyTherapyTools)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Spain
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Curative and rehabilitative care have become a real challenge for developed countries, as they already account for more than 50% of the total healthcare expenditure. Acquired Brain Injury (ABI), the leading cause of death and permanent disability worldwide, represent the main component of these costs, and their prevalence is also growing at great rates. Due to the ABI´s patient chronic condition, the only way to lessening effects or slowing down their disorder is following strict rehabilitation therapies. However, the current rehabilitation model presents a major shortcoming: Lack of impact on patient’s wellbeing at great healthcare cost. In addition, the potential of using telemedicine as an alternative is being hindered by the reduced participation of the clinical community, which turns into solutions that do not address the real ABI patient needs for an effective treatment, such as therapies that combine motor ability, cognition and sensory capacity. After 5 years of research at The Institute of Functional Rehabilitation (IRF) of La Salle University, we have developed integral exercises for the telerehabilitation of ABI, to be practiced at home, to train ADL as well as Activities at Work, compiled into a modular platform called MTT. MTT covers the need to provide cost-efficient, incentive and effective ABI rehabilitation by taking proper advantage of ICT in order to allow taking therapy to ADL, and training all related core functions (motor, cognitive and sensory) simultaneously. MTT operates within the market of Virtual Reality and Telerehabilitation technologies that are experiencing a stunning high growth: CAGR of 19% and 76%, respectively. At the end of SME-Phase 1, we will elaborate a detailed Business Innovation Plan to make us ready for Phase 2 and market uptake following these main objectives: Market study and Validation activities, Deeply study of relevant regulation, monitoring a very dynamic market and IPR integral strategy.

Keywords: acquired brain injury,telerehabilitation,interaction amongst users
Rapid diagnosis of preeclampsia at the point-of-care (PEDPOC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Switzerland,Switzerland
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 219375.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

MOMM Diagnostics conceives a new generation of in-vitro diagnostic tests for early diagnosis of preeclampsia. Preeclampsia remains to this day one of the leading causes for maternal mortality. Early diagnosis is therefore vital to minimize complications and prepare adequately for birth. The startup is developing a solution using microscale solid-state sensors for electrical detection of biomarkers in blood, which would allow the detection of multiple biomarkers, using a single-use cartridge and a hand-held reader for diagnosis of the condition directly where the patients are being taken care of. Technology originating from results of the FETOPEN project RECORD-IT (Project ID: 664786) has shown promising innovation potential. MOMM Diagnostics aims to verify this potential for commercialization by assessing its competitiveness for point of care applications. The technology promises an increased signal to noise ratio at a smaller form factor and lower cost compared to commercially available technologies. The FET Innovation Launchpad will help to consolidate the intellectual property rights and develop a demonstrator to approach investors.

Keywords: biosensor,immunoassay,in vitro diagnostics,point of care,commercialisation
Regioselective Hydrogen Bonding Phase Transfer Catalysis (REGIOFLU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The challenge of performing reactions with catalyst control over regioselectivity has not been met with a general solution. Here, we approach this longstanding problem in the field by addressing the specific question of how to regioselectively install fluorine - a key element in the agrochemical and pharmaceutical industries. By combining the charge-modulating properties of hydrogen bond donors with a phase transfer event, we propose that it will be possible to use simple fluoride salts in regioselective fluorination reactions. Using hydrogen bonding as an activation mode for cheap inorganic salts, we will address new challenges in site selectivity through catalyst design and an extensive interrogation of the potential energy landscape of the reactions. This research will demand catalysts that can control the charge density on a nucleophile and will require computational studies that enable the prediction of regioselectivity on the basis of a nucleophilicity index. To apply the lessons of these studies in the context of asymmetric catalysis, new high performance catalysts will be developed that are capable of kinetic resolution and enantioconvergent allylic fluorination. The ultimate test of the regioselective fluorination methods will be in the synthesis of novel PET tracers, where both time and operational simplicity are critical to achieving a high specific activity. Regioselective hydrogen bonding phase transfer catalysis will strongly influence the broader landscape of catalysis and yield mechanistic insight into a novel synthetic process while providing valuable biological probes from abundant feedstock chemicals. The interdisciplinary aim of this proposal is to connect computational chemists, synthetic organic chemists, radiochemists, and PET imaging specialists in a framework that allows the production of new tools to expedite clinical breakthroughs.

Keywords: hydrogen bonding catalysis,phase transfer catalysis,regioselective catalysis,feedstock,reagents
Optical device to measure the density of the macular pigment in the human eye (OpMaEye)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Age-related macular degeneration (AMD) is a leading cause of blindness in Europe. Since there is a lack of effective treatment modalities, prevention is of signficant importance. There are some evidences that nutritional counseling or intervention might reduce AMD incidence or slow down its progression. In particular, dietary modification or supplement intake may facilitate the increase of the retinal carotenoids lutein (L) and zeaxanthin (Z) that form the macular pigment (MP) and prevent neovascular age-related macular degeneration. In such supplement treatments and follow-ups, regular MP density (MPD) measurements should be essential. Until today, instruments capable of measuring MPD are either psychophysical requiring the subjective responses of the patients (operating on variants of heterochromatic flicker photometry) or are advanced imaging devices that record hyperspectral images of the macula and surrounding areas of the retina. In these instruments, MPD is derived by the relative absorption of the blue part of the spectrum that is characteristic to the absorption spectrum of MP. These instruments are either difficult to use or very expensive. Within the SeeCat-ERC Advanced Grant project, we developed a completely new optical approach to measure and map the MPD. It is practical, compact, cost effective, and can be operated without extensive training and maintenance. In this PoC project (OpMaEye), we aim to further develop the instrument by designing a working compact prototype and performing initial validations.

Keywords: optics,ophthalmic instruments,age related macular degeneration,macular pigment
Circuits for multisensory integration in the perirhinal cortex (RhinalMultiSense)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

While watching a movie or listening to a friend, our brain integrates information from all the senses to build a coherent neural representation of the experience. This allows our brain to assign a voice to each character in the movie and localize it in the visual space, or to anticipate the meaning of our friend’s speech from hers lip movements. This function of the brain is called multisensory integration (MSI) and is a core function of the nervous system. In the mammalian cortex, MSI occurs in associative areas such as prefrontal cortex, posterior parietal cortex and perirhinal cortex (PER). The role of PER in MSI is supported by neuroanatomical data, however the investigation of the circuits underlying MSI in PER has been hampered by technical limitations in manipulating neurons processing a specific information. In RhinalMultiSense I will combine novel technological tools to disentangle the architecture of MSI in PER. I will combine engram technology and viral tracing to describe the inputs impinging onto perirhinal neurons activated by a specific modality. I will then combine engram technology and optogenetics to investigate the output connectivity of these neurons. The results of RhinalMultiSense will inspire new hypothesis and investigation on the function of PER circuits in sensory processing in health and disease.

Keywords: multosensory,somatosensory,vision,perirhinal
FRESH - Find Researchers Everywhere and SHare (FRESH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-06-01
End date: 2018-01-31
Duration (months): 20.0
Total project cost (EUR): 171745.0
EU funding (EUR): 160000.0
Participants: 13
Project status: CLOSED

FRESH (Find Research Everywhere and SHare) is led by the Center for Research and Analysis with 13 partners and 5 associated partners. The Consortium includes Bulgaria’s first technological park, a chamber of industry and commerce, a pan-European organisation, leading research organisations, academia, and media. The aim is to create a series of participatory and media events to promote research careers, aimed in particular towards young people and their parents. Building on existing understanding developed through previous local initiatives including Researchers Night, and with reference to Europe-wide research like the Special Eurobarometer 401, as well as the MASIS report and the in-depth Education and Training Monitor 2015 for Bulgaria , the focus of this 20-month programme will be on enhancing the public understanding of and engagement with science. Core activities during the Night will include a digital participatory campaign to engage audiences across the country; international live streaming; science city quests and quizzes; science cafes; hands-on experiments; science shows; simulations; games and competitions. Thematic programmes will include, among other, food and nutrition, inspired by 2016 International Year of Pulses , engineering, oceanology, innovation and business incubators, technological transfer, medicine, and others. The on-the-ground activities will take place in the largest cities including several where Researchers Night has not been marked. Innovation will be an intricate part of the events through the use of online technology to enhance the physical activity, engage particularly young audiences and to guarantee sustainability outside the lifespan of the project. The activities of the first year will allow learning to accrue from a thorough evaluation. The project will strengthen the capabilities of the partners in organising events for a general audience, and for underserved audiences, including girls and people with hearing disabilities.

Keywords: researchers night,communication,business,entrepreneurship,innovation,bulgaria,competitions,hands on science,awareness,evaluation,audience
Chromosomal domain formation, compartmentalization and architecture (CHROMDOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-07-01
End date: 2025-06-30
Duration (months): 84.0
Total project cost (EUR): 1499350.0
EU funding (EUR): 1499350.0
Participants: 1
Project status: SIGNED

The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation. Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range of action. The folded structure of chromosomes through long-range loops enables mutual interactions of distant genomic loci that otherwise would not be in contact. While crosslinking-based chromosome conformation capture (3C) techniques have revealed the underlying structure of interphase chromosomes, the molecular mechanism of how chromosome-organizing proteins, such as the insulator CTCF or the structural maintenance of chromosomes (SMC) complex cohesin build the chromosomal scaffold and contribute to genomic organization, is not understood. Due to the complexity of the processes involved, biochemical information on how chromosomal proteins contribute to the establishment of TADs is scarce. I have previously demonstrated that single molecule techniques can be used to study the interactions of single cohesin complexes with DNA, chromatin and DNA-bound proteins and to resolve processes that are inaccessible in bulk biochemical experiments. In this project, I will use and expand the high-throughput single molecule technique of DNA curtains to study the molecular details of how chromosomal scaffolding proteins and genetic insulators form the basis for the three-dimensional folding of chromosomes. My experiments will build a novel experimental platform to study the dynamics of chromosomal configuration and maintenance in a reconstituted single molecule assay and will reveal the molecular details that drive the organization of chromosomes into hierarchically organized structures.
Helping Children to Make the Best of their Transition to High School (A.L.I.B.I.)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands,Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-08-01
End date: 2022-01-31
Duration (months): 18.0
Total project cost (EUR): 190714.29
EU funding (EUR): 45000.0
Participants: 4
Project status: SIGNED

Poor social experiences with peers, such as peer rejection or peer victimization, and with teachers, such as receiving low support or having conflictual relations with teachers during elementary school impede children’s self- and stress-regulation. The affected self- and stress-regulation places these children at risk of developing similar troublesome relations with teachers and peers after the transition to high school. We propose to develop a serious game named A.L.I.B.I. to help children make a successful transition from elementary school to high school. In A.L.I.B.I. children play in a virtual high school environment. The objective of A.L.I.B.I. is to uncover an alien, who is disguised as a teacher or peer. By engaging in prosocial interactions with teachers and peers, by taking the perspective of others, by learning to overthink multiple response options before acting, and by valuing long term perspectives over short term goals, children will receive clues that will help them to uncover the alien. The advantage of A.L.I.B.I. is that through the use of a virtual school environment, it provides children a realistic yet safe environment to learn and rehearse prosocial behaviors, to prepare them for the new social environment. In addition, A.L.I.B.I. is intuitively attractive for children, through its use of game elements and presentation on a tablet computer. The proposed ERC PoC grant has the goal to (1) develop A.L.I.B.I. into a stand-alone serious game that will be ready for implementation, (2) to test the effectiveness of A.L.I.B.I., (3) to integrate A.L.I.B.I. in ongoing school transition trainings as provided by three school counseling organizations in three regions in The Netherlands, and (4) to develop a marketing strategy for broader Dutch and European implementation.

Keywords: childhood,elementary school,peer rejection,peer victimisation,teacher child relationship,prosocial behaviour,self regulation
Training in Reducing Uncertainty in Structural Safety (TRUSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Ireland,Spain,Spain,Ireland,Ireland,France,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3701306.88
EU funding (EUR): 3701306.88
Participants: 16
Project status: CLOSED

The growth of cities, impacts of climate change and the massive cost of providing new infrastructure provide the impetus for this proposal – entitled Training in Reducing Uncertainty in Structural Safety (TRUSS) – which will maximize the potential of infrastructure that already exists. If flaws in a structure can be identified early, the cost of repair will be vastly reduced, and here an effective monitoring system would allow identifying the optimum time to repair as well as improving structural safety. But safety is difficult to quantify and requires a deep understanding of the uncertainty associated to measurements and models for the structure and the loads. TRUSS will gather this understanding by bringing together an intersectoral and multidisciplinary collaboration between 4 Universities, 11 Industry participants and 1 research institute from 6 European countries. The consortium will combine and share expertise to offer training at an advanced level as new concepts for monitoring, modelling and reliability analysis of structures are emerging all the time. TRUSS will make knowledge of structural safety grow by incorporating these emerging technologies (hi-tech monitoring and manufacturing, computing, etc.) into the training programme and it will support job creation by enabling a wider talent pool of skilled and accredited engineering graduates with business, entrepreneurship, communication, project management and other transferrable skills. The training programme will be structured into taught modules combined with original research supported by secondments that will expose 14 fellows to both academia and industry. While developing tools that will reduce uncertainty in structural safety and improve infrastructure management, TRUSS will lay the basis for an advanced doctoral programme that will qualify graduates for dealing with the challenges of an aging European infrastructure stock, thereby enhancing their career prospects in both industry and academia.

Keywords: structural assessment,structural safety,reliability and risk analysis,design life,resistance,load,buildings,energy infrastructure,transport infrastructure,bridges