Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A new type adsorption-resorption cycle for the combined power generation and refrigeration driven by low grade heat (ADSOR-RESOR CYCLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-12-06
End date: 2011-12-05
Duration (months): 12.0
Total project cost (EUR): 120144.8
EU funding (EUR): 120144.8
Participants: 1
Project status: CLOSED

A new type of combined cycle of power generation and refrigeration, which is driven by the low grade heat such as the waste heat from chemical engineering factory and combustion turbine, and the low grade heat from solar energy, is proposed in the proposal. This new type cycle mainly includes two high temperature adsorbers with high temperature salt as adsorbent, and two low temperature adsorbers with low temperature salt as adsorbent. The working processes mainly include desorption and resorption processes. The desorption process of high temperature adsorber generates electricity, and the resorption process between two types of adsorbers, i.e. low temperature and high temperature adsorbers, generates refrigeration effect. In order to improve the power generation and refrigeration efficiency, a superheater and a precooler are designed in the cycle. Compared with traditional Rankin cycle that utilizes water as working media for power generation, this new type of combined cycle utilizes ammoniate salt as working media, thus it has higher efficiency because the temperature for desorption process of the ammoniate salt varies in the process of heating, and the average heating temperature of new type cycle is higher than that of water media in the Rankin cycle, which has an isothermal heating phase while the water vaporizes. If compared with combined absorption cycle for power generation and refrigeration, which is based on the Kalina cycle, this new type cycle not only has simple structure, but also has higher refrigeration efficiency for the reason of resorption refrigeration process, and it also has higher reliability because there are very less liquid ammonia exists in the system.

Keywords: design engineering,thermal engineering,hybrid energy systems,technological sciences,generation of electricity,renewable energies
New pincer-type complexes derived from 2-indenylidene ligands (INDEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 165645.6
EU funding (EUR): 165645.6
Participants: 1
Project status: CLOSED

The group of D. Bourissou has recently reported a new family of indenyl-type ligands bearing one or two coordinating side-arms. These new ligands have allowed the preparation of several metal complexes (Zr, Rh, Pd) exhibiting original coordination modes: eta-1 indenyl and 2-indenylidene. In this project, we envision to take advantage of the strong sigma-donor character of such original 2-indenylidene pincer ligands (i) to stabilise oxo and peroxo complexes of late transition metals and (ii) to explore their activity in hydroamination reactions.

Keywords: transition metal complexes,pincer ligands,2-indenylidene,oxo- and peroxo-complexes,hydroamination,non-innocent ligands
Study of uniform supported metal complexes and metal clusters at atomic level for catalytic applications (UNIMETCLUST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 241761.1
EU funding (EUR): 241761.1
Participants: 1
Project status: CLOSED

The discovery and optimization of materials with nanometric dimensions (e.g. supported metal clusters) has aroused high interest in catalysis field during the last years. Based on the fact that some elements, such as gold, show unique catalytic properties when properly synthesized in the form of small crystallites, attention has been mainly paid on controlling the physical-chemical characteristics of the supported nanoparticles at atomic scale, taking into account that this matter is crucial for designing more active and selective catalysts. Particularly, the possibilities of supported metal species containing only a small number of atoms (1–10 metal atoms) are of high interest for application in catalysis, since they no longer act like bulk metals, but tend to offer unique properties in the activation of chemical functionalities. During the present project, we will tackle the synthesis, characterization and reactivity of supported metal complexes, and small metal clusters, for producing solid metal-based materials with properties close the molecular analogues. A hypothesis underlying the research is that these well-defined supported species play a key role in advancing the fundamental understanding of catalysis, in such a way that the study of much more complex nanoparticulated materials (industrial catalysts) can be built on the foundation of this research.

Keywords: supported metal clusters,heterogeneous catalysis,fundamental chemistry,transient studies,exafs/xanes,stem/hrtem
Characterization of Nod factor receptor LYK3 protein-interaction networks during early symbiotic signaling in Medicago truncatula (SYMBIOSIGNAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 234337.9
EU funding (EUR): 234337.9
Participants: 1
Project status: CLOSED

Legumes are able to enter nitrogen-fixing symbiosis with rhizobial bacteria. The use of legumes in agriculture offers a number of advantages, including improvement of soil quality and the avoidance of chemical nitrogen ferlizers, which makes them a key element in sustainable agricultural systems. The rhizobium-legume symbiosis provides a unique experimental system in which to interrogate a signal transduction pathway which affects many fundamental aspects of plant biology. Host perception of rhizobial elicitors, called “Nod Factors”, trigger fluctuations in calcium, alterations in the cytoskeleton, and membrane trafficking. These processes culminate in the formation of a new plant organ specialized in nitrogen fixation called nodule. In recent years, genetic screens in the model legume Medicago truncatula have led to the identification of a number of mutants affected in early signaling responses. Among the genes identified are NFP and LYK3, which encode Nod factor receptor kinases essential for nodulation. Nevertheless, how these receptors perceive and relay the Nod factor signal to each other and to unidentified, downstream effectors of nodule development remains to be established. The main research objective of SymBioSignal is to identify novel elements of the Nod factor signal transduction pathway by analyzing the proteins that interact with the Nod factor receptor kinase LYK3 in M. truncatula. This will involve: (1) the identification of protein targets using tandem affinity purification approaches in combination with mass spectrometry; (2) the characterization of the functional relevance of the interacting proteins and their relationship to early symbiotic responses by means of reverse genetic, cell biological and biochemical studies. Knowledge gained in this project will be beneficial not only for the rhizobium-legume research community, but also for the community investigating cellular signalling in other systems.

Keywords: natural sciences,cell biology,nitrogen fixation,signalling.
Capturing kinase-substrate pairs in intact mammalian cells by using unnatural amino acid mutagenesis and photocrosslinking (KINASE CROSSLINKING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-02-01
End date: 2014-01-31
Duration (months): 36.0
Total project cost (EUR): 245939.9
EU funding (EUR): 245939.9
Participants: 1
Project status: CLOSED

Aim of this project is to develop a method for capturing kinase-substrate pairs in living mammalian cells using unnatural amino acid mutagenesis and affinity crosslinking. Photocrosslinking amino acids (containing benzophenone or azide groups) will be introduced site-specifically into the backbone of target proteins using ad hoc developed orthogonal tRNA/synthetase pairs functional in mammalian cells. By introducing the photocrosslinker at suitable positions into the substrate binding region of a protein kinase, we expect to crosslink its natural substrates in response to cell stimulation and UV irradiation. Likewise, by introducing a photocrosslinker close to the phosphorylation site of a kinase substrate we will aim at capturing it upstream kinase. Once proofed the feasibility of the approach using the PKA/CREB system, we will apply such strategy to identify unknown kinases-substrate pairs involved in signaling pathways regulating fundamental cellular processes (BRCA1 and NF-kappaB pathway). This will represent a new general method for capturing transient protein-protein interactions in vivo by applying a minimal perturbation to the natural system, which will respond to a need of the scientific community, since methods for studying protein-protein interactions available nowadays mostly involve non-native conditions. The use of orthogonal tRNA/synthetase pairs for unnatural amino acid mutagenesis is a very recently developed technique, which is applied in very few laboratories in the world, and which has a tremendous potential for enabling the study of protein structure and function directly in the living cell. In the outgoing phase the fellow intends to learn this technique and explore new possibilities of its application. This knowledge will be applied in the return phase to study a major research target of the return host. The establishment of this technique in European countries will increase the competitiveness of the European research in the biomedical field.

Keywords: non natural amino acid mutagenesis,orthogonal trna/synthetase pair,kinase,phosphorylation,affinity crosslinking,photocrosslinking,protein-protein interactions,brca1,nf-kappab,bpa,apa
Novel Supramolecular cylinders and their interaction with DNA; probing effects of cylinder structure and targeting DNA junctions (CYLREC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 180603.2
EU funding (EUR): 180603.2
Participants: 1
Project status: CLOSED

The scientific aim of this proposed project is to understand what features of nanoscale synthetic cylinders, and which biomolecular binding mode, give rise to the observed biological effects on the cell cycle and to probe the mechanism and temporal relationships of that action in more detail. Our hypothesis is that the cylinder recognition of Y-shaped junctions, particularly replication forks, is a key feature of their action. The new design strategies will create cylinders which deconvolute the two different DNA binding modes (Y-shaped junction or major groove) and are founded on careful analysis of the X-ray structure of the 3 way junction and an NMR structure of the major groove binding: the designs add functionality to prevent one of these two binding modes while permitting the other. Within each overall design strategy, a number of different cylinders are proposed and, as detailed, the results of the biophysical and cell delivery studies will be used to optimise the design and select the most suited.

Keywords: dna junctions,y-shaped junctions,supramolceular chemistry,supramolecular cylinders,nanoscale synthetic cylinders,drug-dna interactions,replication forks,cell cycle,synthetic dna-binding drugs
Tailoring crossover properties by electric field in nano-structural and liquid crystalline molecular based magnetic materials (ELECTROSCO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 153417.0
EU funding (EUR): 153417.0
Participants: 1
Project status: CLOSED

Spin crossover (SCO) systems are functional molecular materials possessing labile electronic configurations switchable between the high- (HS) and low-spin (LS) states in response to external stimuli (temperature, pressure, light, sorption, phase transition). In the HS and LS states SCO materials reveal differences in magnetism, optical and dielectric properties, colour and structure. SCO materials are one of the most important examples of bistable molecular materials with potential applications as sensors, electronic memories and in opto-electronics. A rational control of the SCO-properties is required, in particular at nano-metric scale, if they have to be successfully integrated into functional devices. The present research proposal has two research lines. The first one includes: 1a) Development of nano-structured cooperative spin crossover metallorganic frameworks (SCO-MOFs) following the ‘bottom-up’ synthetic approach; 1b) Nanoscale patterning of SCO-MOFs; 1c) Detection of magnetic, optical and dielectric bistability in SCO-MOFs at nanometric scale in external electric field. The second line will be guided towards: 2a) Development and investigation of new charged and neutral SCO systems with liquid crystalline properties (SCO-LSs) with strong intermolecular hydrogen bonding; 2b) Study of SCO properties of SCO-LCs under external electric field.

Keywords: spin crossover,nano-chemistry,electric field,host-guest chemistry,liquid crystals,thermochromism,dielectric constant
Natural Sources of Aphid Resistance in Arabidopsis (SARA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-08
End date: 2012-07-07
Duration (months): 24.0
Total project cost (EUR): 165645.6
EU funding (EUR): 165645.6
Participants: 1
Project status: CLOSED

Aphids are worldwide a serious pest on many plants, including important crops. The species Arabidopsis thaliana displays a large amount of natural genetic variation in resistance against the green peach aphid Myzus persicae. This project will exploit this natural genetic variation for mapping of quantitative trait loci (QTL) for Myzus resistance in publicly available Arabidopsis recombinant inbred lines, with a subsequent characterization of the causal genes. The objectives of the proposed project are (i) fine-mapping of one (or more) resistance QTL, (ii) cloning of the underlying genes, (iii) understanding of the mechanistic role of these genes and their gene products in defense against aphids, and (iv) decoding of the evolutionary trajectory of these genes by analyzing patterns of nucleotide variation within Arabidopsis thaliana and among close and distant Arabidopsis relatives. This project will lead to new insights into plant-insect interactions in general and plant-aphid interactions in particular, not only from a functional but also from an evolutionary perspective. It will help to dissect the genetic basis of plant resistance against aphids and will open up new perspectives for sustainable agriculture.

Keywords: plant genetics,natural genetic variation,arabidopsis,plant-aphid interactions,molecular genetics,population genetics,evolution,ecology
Quantitative functional assessment of gene therapeutics for Muscular Dystrophy (QUESTFORMD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 232427.2
EU funding (EUR): 232427.2
Participants: 1
Project status: CLOSED

Dystrophin is a large cytoskeletal protein that makes a bridge between the cytoskeletal actin microfilaments in muscle cells and the extracellular matrix, through the Dystrophin-Dystroglycan complex located at the plasma membrane. This strong link is responsible for conferring resistance to muscle contraction. Duchenne Muscular Dystrophy (DMD) is an X-chromosome linked disease caused by a mutation on the Dystrophin gene that results in damage to muscle fibers. Affected individuals rarely live beyond the third decade of life. Gene therapy is being trialed to replace the mutant protein. Since Dystrophin is a large protein, proposed gene therapies employ truncated versions of Dystrophin. Therapy faces delays because of poor understanding of the protein stability and levels required for functional recovery in the in vivo context. This proposed project aims to explore how Dystrophin stability and turnover is modulated by its structural domains, taking advantage of cutting edge in vivo imaging techniques applied to the zebrafish model. Several truncated Dystrophin constructs, containing different combinations of specific rod regions, are used on trials. The hypothesis that these differ in their ability to replace natural Dystrophin will be tested. By imaging Dystrophin-GFP fusions after genetic manipulation of single cells in the live animal, we will determine Dystrophin dynamics and function in the living organism at the single cell level, leading to insights into cytoskeletal biology. We will test the ability of truncated human Dystrophins to rescue zebrafish dystrophin mutants and determine how much, and when, Dystrophin is required to rescue muscle structure and function. Our proposal strongly promotes transfer of knowledge between developmental biology and applied clinical research. The project will establish the applicant as a key member of a multidisciplinary international team aiming to develop time- and cost-effective initial screens for gene therapeutics.

Keywords: gene therapy,developmental biology,muscle development,dystrophin,muscular dystrophy,dmd,zebrafish development
Do consumers value food labels? An assessment of the impact of information and personality traits on the demand for food labels (FOODLABELS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 230961.1
EU funding (EUR): 230961.1
Participants: 1
Project status: CLOSED

In recent years, changes in economic, social, cultural factors, as well as in tastes and consumers preferences and the increasing availability of products are driving consumers to change their eating habits. Consumers are gradually assigning more importance to the diet-health relationship when making their food choices. They have also become more concerned with environmental issues. Health considerations and food safety rank first among the buying motives of food products. In addition, environmental protection, a controlled quality and the products` natural state are central reasons for purchasing organic food. Consequently, consumers face increasing information on health and nutritional food characteristics, an important amount of which is presented on food packages labels. Hence, the objective of the proposed research is to assess to what extent consumers would value the provision of multiple food labels, when making food choices. The specific objectives of the project proposed are: 1) to segment consumers into groups depending on psychological/personal factors (attitudes, lifestyle, environmental and ethic values, eating habits, lifestyles etc), 2) to identify food labels that Spanish consumer would value more than others, 3) to find the maximum willingness to pay (WTP) for food labels, and 4) to analyze how information and personality traits affect the consumer Willingness to pay. The experimental auctions methodology and surveys are proposed to undertake the overall objective of the project. Understanding how consumers value healthier food products is relevant in devising optimal strategies to improve consumer eating habits and to positively affect on health system’s expenditures. The further reason to carry on this proposed project is the dissemination of information of the climate and environment impacts of the foods consumers eat.

Keywords: social sciences,applied economics,agricultural economics,econometrics,microeconomics,consumer economics,marketing
Physics of the tau lepton: from chiral dynamics to lepton flavour violation phenomena (TAU DECAY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-11-18
End date: 2012-11-17
Duration (months): 24.0
Total project cost (EUR): 153593.0
EU funding (EUR): 153593.0
Participants: 1
Project status: CLOSED

The goal of the project is to study hadronic decay modes of the tau lepton in the Resonance Chiral Perturbation Theory, use these results to improve their description in the Monte Carlo generator TAUOLA and make thereby possible an adequate analysis of the large data samples of tau lepton decays collected at the B factories. Results of such analysis will allow one to perform sensitive tests of the Standard Model and extract its fundamental parameters, such as the coupling constant of strong interactions, the CKM matrix element |V_us|, the hadronic contribution to the theoretical estimate for the anomalous magnetic moment of the muon and others. In addition, modelling of hadronic form factors will help in searches for lepton flavour violating decays of the tau lepton with hadrons in the final state.

Keywords: physical sciences,quantum field theory,elementary particles and fields,chiral models,tau decay