Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synthetic Neurons and Artificial Photoactivated Synapses (SYNAPS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1688047.0
EU funding (EUR): 1688047.0
Participants: 1
Project status: SIGNED

The brain is a complex network of inter-connected neurons that communicate through synapses. SYNAPS aims to for the first time mimic such synapses using liposomes as artificial cells, and visible light to trigger a signal from a ‘sender’- to a ‘receiver’-liposome. Mimicking such communication processes will help with understanding how complex natural emergent properties arise, and could ultimately allow for the construction of a chemical computer. SYNAPS will excel beyond the state-of-the-art by maintaining chemical isolation between liposome interiors, ensuring local, time-bound communication between connected liposomes, and using light as an external stimulus and fuel. These concepts are essential to construct artificial tissues that can communicate on an individual liposome-to-liposome basis, in contrast to the state-of-the-art where communication generally occurs with the bulk solution. To achieve this, a messenger compound will be locally photosynthesised through transmembrane electron transfer by porphyrin dimers that portray a charge-transfer excited state. The liposomes will be organised into a synaptic cleft through the use of synthetic complementary clustering compounds that provide stable adhesion between sender and receiver liposomes. The messenger compound will be recognised by reversible and selective membrane-spanning receptors in the receiver liposome, that will output the signal through fluorescence. In addition, a reaction cascade network will be constructed involving the messenger to produce an artificial action potential, that is, a transient peak in the concentration of the messenger, ensuring a time-bound dissipative signal. Altogether, SYNAPS will provide advances in systems chemistry by providing a nanoscale platform for communication between chemically isolated systems, but also results that are useful for applications such as light-to-chemical energy conversion, chemical sensing and smart drug-delivery.

Keywords: photochemistry,photocatalysis,systems chemistry,biomimetics,supramolecular chemistry,liposomes
Fast, easy diagnostics for personalised phage therapy (Phagediag)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-10-31
Duration (months): 33.0
Total project cost (EUR): 3104962.5
EU funding (EUR): 1800000.0
Participants: 1
Project status: SIGNED

Personalised phage therapy using magistral preparations of phages is among the most promising solutions to fight antimicrobial resistant infections, but this approach requires a rapid diagnostic that identifies the pathogen(s) involved in the infection and the phages active on them. Vésale Bioscience has developed the “Phagogram”, the first automated in-vitro diagnostic tool that enables a fast determination of bacteriophages suitable for treating a particular bacterial infection. It consists of a basic test kit (a disposable well plate with reagents), a high-performance luminometer and a dedicated software that proposes the best matching phage cocktail to treat the patient. Compared to the current diagnostic methodologies, which take up to 4-7 days, the Phagogram compares the activity of up to 96 phages on a bacterial culture within 2-3 hours, making phage susceptibility testing accessible for hospital microbiology labs and enabling personalized therapy on a routine basis.

Keywords: bacteriophages,amr,phagogram,nosocomial infections,antimicrobial resistance,phage therapy,phages,antimicrobial multiresistant infections
Targeted Probes and Nanoparticles: Advancing Host-Driven Clearance of Recalcitrant Bacterial Pathogens (BactErase)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Antimicrobials are the cornerstone of modern medicine, essential for treating millions of people worldwide. Without effective antibiotics, even minor surgeries and routine operations could become high-risk procedures due to untreatable infections. Antimicrobials save lives and contribute, on average, 20 years to global life expectancy. However, the overuse of these drugs and the emergence of antibiotic-resistant bacteria are severely diminishing their therapeutic effects, making treatment increasingly difficult or even impossible. This phenomenon, known as antimicrobial resistance (AMR), is a growing health crisis that threatens to undermine the foundation of medical treatment that doctors, patients and public have come to rely on. Currently, an estimated 4.95 million deaths per year are associated with drug-resistant pathogens, with 1.27 million directly attributed to bacterial pathogens resistant to existing antibiotics. Hence, to address this urgent health challenge, new strategies are critically needed to contain, control and mitigated the spread of AMR. In this respect, BactErase proposes a novel host-directed therapy that leverage the natural ability of resident macrophage to utilize macroautophagy - a process that cells use to degrade and recycle intracellular components - to eradicate intracellular invaders. The primary goal of this proposal is to develop a bacteria-specific probe that can uniquely discriminate the bacteria within the cells and to design nanoparticles preferentially targeting infected cells. This approach aims to enhance the host’s intrinsic ability to resolve drug-recalcitrant infections while minimizing the risk of antimicrobial resistance development. By exploiting the host’s own mechanisms for bacterial clearance in conjunction with selective nanoparticle delivery, BactErase offers an attractive alternative to conventional antibiotic therapy, potentially remodulating the treatment of infectious disease.

Keywords: antimicrobial resistance amr,nanomedicine,drug delivery
Adaptation Strategies for the Elderly in Multi-domain Indoor environments - Well-being and Building Energy Consumption (Age-Adapt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

Europe faces significant challenges, such as an ageing population, shortage of energy, and climate change. As elderly people's physical and adaptive abilities decline, their needs for health and comfort in the indoor environment rise. The gradually expanding elderly population may result in increased building energy consumption and a higher carbon footprint. However, indoor comfort standards are usually targeted at healthy young populations and address singular domain environment. Little knowledge is in the literature about how to balance well-being and energy consumption in multi-domain indoor environments (thermal, visual, acoustic and indoor air quality) for older adults. This knowledge gap has motivated Age-Adapt. We aim to improve well-being and minimize energy consumption by comprehending the adaptive cycles for elderly people in the multi-domain indoor environments , enabling us to propose adaptive strategies. A three-stage hierarchical research methodology combining living lab experiments with fixed and adjustable environmental conditions and field investigations will be created, allowing to: 1. Assess the effects of multi-domain indoor environments on the physiological, behavioural, and psychological adaptation of older adults. 2. Assess the role of physiological, psychological, and energy consumption benefits after behaviours have occurred. 3. Create models, evaluations, and strategies for adaptive comfort in indoor multi-domain environments for older adults at different health levels. The impact of Age-Adapt on the scientific community, industry and the general public will be significant and sustainable: it will offer input into the establishment of indoor environmental design standards and behavioral adaptation guidelines for elderly people, drive the development of products for indoor environmental comfort and health management, and contribute to the goals of healthy aging and climate neutrality.

Keywords: adaptive comfort well being elderly indoor environment health multi domain occupant behavior
Afroeurope and Cyberspace: Imaginations of Diasporic Communities, Digital Agency and Poetic Strategies. Unravelling the Textures (AFROEUROPECYBERSPACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1499864.0
EU funding (EUR): 1499864.0
Participants: 1
Project status: SIGNED

This project explores how Afrodiasporic communities in Europe rise above the public silencing of their perspectives by using the internet to re-appropriate the discourse of who they are, what contexts they relate to and why. Recently, we have seen a notable increase of websites coordinated by people of African descent. Research so far has only investigated isolated cases, ignoring synergies and networks. My project fills this gap by exploring how individuals and collectives that identify as African/Afrodescendant use the internet to establish alternative public spheres. It will provide seminal answers to the following questions: How do Afrodiasporic communities deal with racialization on the internet? Do they successfully create a space online to articulate their own (self-)images, participate in knowledge production and gain agency? How do they position themselves as members of a (transnationally connected) African diaspora? What challenges do they face? The project’s geographical frame is Romance-speaking Europe, but it also includes sources from the Americas and Caribbean to unveil transnational similarities and local peculiarities. Exploring rhetorical and poetic strategies, the project studies not only what is said but also how it is said. It places major focus on investigating the shared textual and visual language used to deal with racialization and to establish a vision of collectivity. Building on my experience, I combine postcolonial and (digital) media studies with suitable literary/cultural studies’ methods to unravel the ‘textures’ and decode the imaginaries of websites (ranging from texts to auditive/visual elements). The project’s impact lies in helping us understand the cultural narratives that shape emerging Afrodiasporic subjectivities. It also provides seminal insights for the ongoing sociopolitical debate on migration to, and structural racism in Western societies that tend to only speak about these communities without listening to what they say.

Keywords: digital media studies,digital diaspora,afroeuropean studies,african european studies,diaspora studies,postcolonial studies,romance literary and cultural studies,
Evidence Management for Continuous Certification as a Service in the Cloud (EMERALD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Spain,Germany,Austria,Italy,Poland,Finland
Call: Development and validation of processes and tools used for agile certification of ICT products, ICT services and ICT processes (HORIZON-CL3-2022-CS-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 5498900.0
EU funding (EUR): 4736427.5
Participants: 11
Project status: SIGNED

Cloud-based services have grown from basic computing services to complex ecosystems, comprising (virtual) infrastructure, business processes and application code. These advanced services also increasingly leverage the usage of Artificial Intelligence, including Machine Learning or Natural Language Processing techniques, raising the complexity even higher. Due to the cascade of dependencies among the different products and services, the need arose to bring more agility to the certification process of cloud-based services, e.g., using continuous monitoring and assessment, as evidenced by references to it in the certifications of the EU Cybersecurity Act (EU CSA). To transform the continuous assessment and certification concept into the complete realization of a Certification-as-a-Service (CaaS), several challenges need to be solved: 1) current proposed proofs of concepts for continuous monitoring lack interoperability at technology level, 2) the adoption of cloud and edge computing and the incorporation of regulations on specific topics or domains, such as AI, put significant strain on companies to comply with a multitude of different security schemes, 3) existing market fragmentation for continuous certification (scope, methodologies), hinder transparency and accountability in the provision of European cloud services, 4),smart tools and models need to be adopted to ease the agile application and implementation of the CaaS concept reducing complexity in the whole cloud certification value chain easing the adoption of CaaS by the different stakeholders. To overcome these challenges, the design and implementation of the EMERALD CaaS solution leverages the H2020 project MEDINA’s outcomes and advances them to TRL 7 in the EMERALD core. Two PoCs will be provided; one for composite certification and one for mapping requirements to upcoming AI certification schemes. EMERALD will pave the road towards CaaS for continuous certification of harmonized cybersecurity schemes.

Keywords: continuous certification,compositional certification
Seaweed based market applications (SeaMark)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Faroe Islands,Denmark,France,Netherlands,Germany,Sweden,Ireland,Portugal,Lithuania,Iceland,Norway,United Kingdom
Call: Unlocking the potential of algae for a thriving European blue bioeconomy (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 10114239.5
EU funding (EUR): 8279720.25
Participants: 25
Project status: SIGNED

Seaweed is a valuable and underutilised resource that has large potential for exploitation in a variety of markets. Seaweed cultivation is a natural solution for mitigating climate change. The European seaweed industry remains in its infancy and requires significant growth in order to become commercially viable. Seamark will utilise recent ground-breaking selective breeding technologies within EU seaweed crop genetics to increase biomass yield. SeaMark aims to upscale circular ocean seaweed cultivation and land-based integrated multi-trophic aquaculture (IMTA) systems and develop novel processing methods involving fermentation and biotransformation into twelve innovative seaweed-based products. The entire value chain will be analysed for techno-economic feasibility and socio-economic impact. SeaMark will also identify and quantify ecosystem services provided by seaweed cultivation. This will feed into a strategic development plan for upscaling seaweed production, and addressing the carrying capacity of seaweed cultivation in Europe. Due to the need to build more resilient food systems and decrease reliance on fossil-based products, it is necessary to grow the blue bio-economy through seaweed cultivation and product innovation. SeaMark will help fulfil the United Nations Sustainable Development Goals (3, 8, 9, 12, 13 & 14) by developing this industry and, simultaneously, providing a positive impact on people and the planet.

Keywords: ecosystem services sustainable alga based products bio based functional food and feed ingredients and additives seaweed cultivation selective breeding seaweed crop genetics
new VALue landscapes for plant PROtein Pathways (VALPRO Path)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Ireland,Denmark,Italy,Greece,Germany,Spain,Netherlands,United Kingdom,Serbia
Call: Developing sustainable and competitive land-based protein crop systems and value chains (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 9580339.88
EU funding (EUR): 8658160.51
Participants: 25
Project status: SIGNED

The current European plant-protein landscape is flawed. Heightened societal awareness of the environmental impact of consuming animal-based protein is driving the public’s awareness of alternative, sustainable sources of dietary protein. Yet, production systems are focussed heavily on the production of feedstock for direct transfer into animal sectors in an attempt to counter the EU’s over-dependency on imported feed. In essence, there is an absence of premium supply chains - farmers miss out on added-value opportunities that exist within the crops they already grow across Europe. There is a need to increase resilience in farming systems to mitigate against increasingly volatile climate patterns and to support farming systems to meet Farm-to-Fork strategic objectives. Built on the principles of co-creation, innovation and demonstration, VALPRO Path will design, validate and deliver sustainable and competitive plant protein crop systems and value chains. Focussed on underpinning economic value for all actors in the supply chain, it will exploit beyond state-of-the-art innovations, demonstrating and evaluating potential across 5 multi-stakeholder ‘living lab’ innovation production systems (IPSs). With strong industry involvement, the project will deliver a stronger ecosystem for plant protein production, supported with robust evidence of the social, economic, environmental, climate and health benefits. VALPRO Path will deliver new, sustainable business models, showing how focussed research can come into practice. Sustainable diversification of rotations with grain legumes will support the transition to more environmentally sustainable farming. European agriculture is at a juncture in regards to the sustainable provision of dietary protein. It can embrace opportunities presented through existing innovations that are integrated into real-life scenarios to support stakeholders realise the new market opportunities that exist for indigenous, fully traceable plant protein.

Keywords: circular agriculture,lcsa life cycle sustainability assessment,sustainable production,co creation,value chain,business model,decision support tool,mathematical modeling,nutrition,living lab
AN AI ON-DEMAND PLATFORM TO SUPPORT RESEARCH EXCELLENCE IN EUROPE (AI4EUROPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Ireland,Sweden,Slovakia,Spain,Norway,Greece,Germany,Netherlands,Belgium,Italy,Finland,Slovenia,Portugal,France,Romania
Call: European coordination, awareness, standardisation & adoption of trustworthy European AI, Data and Robotics (AI, Data and Robotics Partnership) (CSA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 9004813.51
EU funding (EUR): 8992796.0
Participants: 24
Project status: SIGNED

Europe is implementing an AI strategy that seeks to create a research environment characterised by scientific excellence and consistent with the fundamental ethical values of its citizens. Part of this strategy foresees the consolidation of ongoing research activities through the creation and maintenance of an AI on-demand Platform that will act as a community resource for the research community, facilitating experimentation, knowledge sharing and the development of state-of-the-art solutions and technologies. AI4Europe builds on the work of AI4EU and multiple supporting projects (ICT-48/ICT-49), creating an open, impartial, and collaborative Platform, built by the European research community according to their needs. Equipped with the necessary hardware, the Platform will offer interoperable services, data, and tools from several related communities and provide solutions to facilitate research productivity, reproducibility, and collaboration. AI4Europe will establish and support mechanisms to foster exchange between academia and industry and ensure the Platform reaches out to and engages with the next generation of researchers and those in widening countries. The project will develop and implement a business model that will ensure the long-term technical and financial structures providing sustainability for the Platform beyond the lifetime of the project. AI4Europe will support the community to create a tool that will help position Europe as the place where the very best AI research is conducted.

Keywords: artificial intelligence,digital platform,research experimentation,research reproducibility