Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-level Programming of Heterogeneous Multi-core Computing Systems (ASSISI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-11-05
End date: 2012-11-04
Duration (months): 24.0
Total project cost (EUR): 217673.6
EU funding (EUR): 217673.6
Participants: 1
Project status: CLOSED

Heterogeneous multi-core computing systems become very important for solving computational problems because of increased processing power they deliver and better energy efficiency. However, even experienced high performance programmers find it a challenge to fully exploit their potential due to the novelty and variety of available architectures. What&apos;s more, currently used programming languages, compilers and software development techniques are not adequate for programming of the new kind of systems, which hinders programs development and hampers software portability. A number of research and industrial projects addresses the challenge of programming the heterogeneous multi-cores at a higher level. The efforts are mainly based on sequential programming languages like C or C++. In our project we propose to address the challenge by adopting Chapel, a high level programming language. Its important feature is the rich support for parallel programming at various levels of abstraction. However, its programming model does not address issues vital for heterogeneous multi-core systems. We will enhance Chapel with features and concepts that are specific to heterogeneous multi-core architectures. Furthermore solutions for enhancing performance portability in the context of Chapel will be proposed. The applicant has extensive experience in parallel processing. His visit of the Host (the University of Vienna) will enable him to work with Europe&apos;s leading experts in high level parallel programming languages and attain complementary knowledge that is crucial for his future independent research in the emerging multi-core systems. The visit will allow him to expand the network of collaborations and the attained experience will significantly increase the potential for the further career development, from current position of an assistant professor to associate professor.

Keywords: software technology,computer technology,parallel processing,parallel programming languages,heterogeneous multicores
Identification and functional analyzis of the subnuclear protein complex of phytochrome B photoreceptor in Arabidopsis thaliana. (PHYB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 161661.0
EU funding (EUR): 161661.0
Participants: 1
Project status: CLOSED

Light is one of the most important environmental signals regulating a wide range of physiological and developmental processes in plants, from seed germination to flowering. To perceive changes in the light, plants evolved photoreceptors specialized in absorbing light of different wavelengths. Phytochromes are the red/far-red light-absorbing photoreceptors of plants. Phytochromes (phyA-phyE) control responses throughout the plant life like seed germination, seedling de-etiolation, shade avoidance and transition of flowering. PhyA and phyB are the most prominent phytochromes to mediate photo-morphogenesis under normal conditions and phyB has major role to control light responses in mature, de-etiolated plants. To date, little is known about phyB mediated signalling cascade, however, clear evidences show that a specific set of genes are regulated by phyB-signalling. Light induces nuclear import of phy (A-E) and formation of phytochrome-containing nuclear protein complexes termed speckles or nuclear bodies (NBs). Although the precise function of NB formation is unknown, it is tempting to speculate that NBs are closely associated with phyB signalling. The project aims to unravel the link between phyB-NB formation and phyB signalling. I would like to purify and determine the components of phyB containing subnuclear complexes from Arabidopsis thaliana using tandem affinity purification (TAP) method and mass spectrometry. After determination of NB complexes, the biological function of identified protein components would be examined on multi-level from plant physiology to molecular biology. As we expect, we can uncover new factors and downstream steps of phyB mediated red-light signalling pathway after NB formation. Determination of phyB-signalling complex could also help us for better understanding the cross-talk between other signalling pathways.

Keywords: plant photobiology,photomorphogenesis,photoreceptor,phytochrome,light signalling,nucear bodies,protein complex purification,arabidopsis thaliana
Bacterial alginate: isolation, fine structure characterization and role in aerobic granular sludge formation (BAAGS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-08
End date: 2012-09-07
Duration (months): 24.0
Total project cost (EUR): 170535.2
EU funding (EUR): 170535.2
Participants: 1
Project status: CLOSED

Aerobic sludge granulation is a promising innovative technology with the potential to be an alternative to the activated sludge process. It allows running a wastewater treatment plant with 30% less energy input, and requiring 75% less space combining with significant lower investment costs. Aerobic granules’ stability is the main concern of this process. It is strongly connected with the property of exopolysaccharides, particularly the bacterial alginates, which have been recently shown to be more than 10% of aerobic granules’ organic carbon content. Determining their function based on clearly defined analytical methods is significant for bringing this technology into practice. The proposed research aims at establishing and utilizing integrated analytical methods for looking into functional exopolysaccharides and their fine structures, and elucidating its role in aerobic granular sludge formation and stability based on their structure-function relationship. Bacterial alginates will be isolated both from the lab-scale and pilot-scale reactors. Their properties as block fraction, fine chemical structures, monomer ratio, molecular weight, acetylation degree, and etc. will be studied by chemical and advanced instrumental analysis as UV-visible, FT-IR, MALDI-TOF MS, NMR, MS-GC and etc. A qualitative and quantitative correlation between bacterial alginates’ property alteration and aerobic granular sludge formation and stability will be presented. Methods established will greatly facilitate exopolysaccharides research in aerobic granular sludge area; knowledge obtained will provide insight on exopolysaccharides function both in aerobic granules and normal biofilms. This research will accelerate aerobic sludge granulation technology leadership by EU; enhance EU scientific excellence in exopolysaccharides advanced characterization, provide researcher an advanced level of training, and increase European Research Area’s attractiveness to researchers all over the world.

Keywords: natural sciences,environmental science,water science,wastewater treatment
Specification and Implementation of Pattern Languages (SIMPL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 173903.2
EU funding (EUR): 173903.2
Participants: 1
Project status: CLOSED

The proposal is aimed at helping to provide robust and transparent data infrastructure for the future Internet (which is a part of the European Commission ICT Challenge 1: Pervasive and Trustworthy Network and Service Infrastructures). The primary object of research is data, in contrast with computation. Therefore we will be interested mainly in kinds of formal data certification rather than in certified interpreters, etc. This however does not exclude possibilities for a crossroad research where these two paradigms overlap. Research objectives: 1) Theoretical representation of extended, or, practical, regular expressions in constructive dependent type theory. (We will overcome redundant assumptions regarding equality of languages that lay in the foundation of today&apos;s simply typed theories of practical regular expressions.) 2) A Coq library for regular languages and automata that includes features not present in available related libraries, such as extended regular expressions and partial derivatives of regular expressions; and a Coq library for pattern languages that provides full support for backreferences. 3) A formally certified compiler of patterns into automata; a formally certified grep-like pattern parser. 4) A formally certified UTF-8 encoder/decoder. 5) A formally certified data description language for describing binary data format specifications with a possibility to prove meta-properties of data specifications, such as completeness or consistency; in other words, a language for production of formally certified specifications of data formats. Main research questions: 1) What is the efficiency of the derivative approach in computation of context-sensitive features or extended regular expressions? 2) How can one define partial derivatives of regular expressions with backreferences? 3) What is the dependent type of partial derivatives of regular expressions with backreferences?

Keywords: modelling tools,mathematical logic,algorithms,automaton,context-sensitive,data description,dependent type,formal language,grammar,parsing,partial derivative,pattern,regular expression
Septin organization by multiparameter photoactivated localization microscopy (PALMSEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 173065.2
EU funding (EUR): 173065.2
Participants: 1
Project status: CLOSED

The septins are a conserved family of GTPases that interact with membranes and the cytoskeleton. Several different septin molecules combine into nonpolar dimeric rods. These rods are thought to assemble end-over-end into higher order structures that orchestrate complex cellular events at the interface of the cytoskeleton and the plasma membrane. In this way, septin complexes organize the cleavage furrow in dividing cells, serve as a corset to maintain cell shape in cell motility, engulf invading bacteria and control the morphological differentiation of nerve cells. The integrity of the complexes is essential for septin function. However, the architecture of septin complexes and the rules guiding their assembly, while seemingly conserved from yeast to mammals, are not clear. The main objective of this study is thus to understand the rules controlling the assembly of septin complexes from subunit rods in yeast and mammals and to find out, whether there are alternative models to end-over-end assembly of septin rods into complexes. Individual septin rods will be localized within complexes with nanometer precision using ultra-resolution fluorescence microscopy methods. The septin complex architecture will then be modeled from the resulting pattern of individual rod positions. As a starting point, the best-understood septin complex, the ring-shaped complex at the mother bud neck in yeast involved in cytokinesis, will be investigated. First conclusions from the analysis of this complex will aid in the investigation of a mammalian septin complex at the neck of dendritic spines in neurons. Neither the precise composition nor the global structure of this septin complex are known yet, but morphological and functional analogies of the spine neck with the yeast bud neck suggest that a similar septin-ring structure may be present. The expected results will clarify the role of the septin complexes in yeast cell division and define the rules for septin complex assembly in neurons.

Keywords: cell biology,molecular biophysics
Isotope constraints on the contribution of metal-rich magmatic fluids to back-arc seafloor hydrothermal systems (ISOBAB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-02-22
End date: 2013-02-21
Duration (months): 24.0
Total project cost (EUR): 230747.2
EU funding (EUR): 230747.2
Participants: 1
Project status: CLOSED

Chemical exchanges between the lithosphere-ocean-atmosphere are focused at the active plate boundaries and are important in the global geochemical balance. Eventually, they may influence climate and impact on human activities. Hydrothermal circulation at these boundaries is the engine that transfers chemicals between the lithosphere and ocean. However, the structure of lithospheric contribution (hydrothermal leaching of solid rocks vs. direct mantle degassing) to the ocean chemistry is poorly understood. Insight into this problem (sources of metals and location of ore deposits) becomes increasingly important with the current interest in mining seafloor deposits and has high societal relevance. Unique seafloor hydrothermal processes in back-arc basins (BAB) produce a wide range of vent fluid chemistry and mineral deposits, and are considered as critically important for the genesis of volcanogenic massive sulfide deposits. While it has been suggested that input of magmatic fluids plays a crucial role in the chemistry of the BAB hydrothermal systems, its contribution as source of both transition and precious metals, has been a matter of debate. We propose a research project aimed at providing new constraints to define the relative role of metal-rich magmatic fluids and sub-seafloor metal precipitation/remobilization in BAB mineralization. We will achieve this goal studying non-traditional isotope (Cd-Zn-Sb) systematic of seafloor hydrothermal systems (substrate rock-fluid-deposit) in a spectrum of seafloor hydrothermal fields (from basalt- to dacite-hosted) in 2 BAB (Manus, Lau). This project is backed-up by results from previous studies that suggest contribution of magmatic volatiles, and that the available sample set is ideal for testing our hypotheses. It is expected that insight gained from Cd-Zn-Sb isotope systematic has great potential to improve our understanding of fundamental sub-seafloor processes responsible for metallogenesis in BAB hydrothermal systems.

Keywords: geochemistry,stable isotopes,zinc,cadmium,antimony,hydrothermal,seafloor,back-arc basins,vents,magmatic
New Synthetic Reactions for Antitumor Natural Products (NSR-ANP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-05-03
End date: 2013-05-02
Duration (months): 36.0
Total project cost (EUR): 250229.8
EU funding (EUR): 250229.8
Participants: 1
Project status: CLOSED

This project seek to study potential advances in organic synthesis and to apply such advances to the elaboration and study of natural products or natural product congeners of novel biological activity. This project has three main goals of broad relevance. The first is the development of new chemistry, (both in terms of strategy as well as specific reactions) to assist in the synthesis of complex target systems. The second is the application of this chemistry to the synthesis of potentially useful anticancer agents bearing a priviledged and natural-ocurring dipyrrolo[1,2-a:1&amp;apos;,2&amp;apos;-d]pyrazine core. Thus, natural products such as phakellins, phakellstatins, palau&amp;apos;amine, spirotryprostatins and structure related to natural products provide the focus for our synthetic efforts. Finally we hope to evaluate, albeit on a qualitative basis some notions as to the mode of action of these substances. It is anticipated that such studies will help to clarify chemical possibilities which might be of relevance to drug activation. This project provides an excellent framework to the transference of chemical efforts to medicinal research in diseases of global impact, such cancer is nowadays.

Keywords: organic chemistry,medicinal chemistry,catalysis,biological evaluation
Assembly of a prostate cancer genome-wide molecular interactome for the identification of the key regulatory genes of malignant transformation and new targets for therapeutic intervention (PC INTERACTOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-08-02
End date: 2013-08-14
Duration (months): 36.0
Total project cost (EUR): 241761.1
EU funding (EUR): 241761.1
Participants: 1
Project status: CLOSED

A major issue in the translation of findings from mouse models to clinical practice is the lack of appropriate tools to identify causal mechanisms of oncogenesis, tumor progression, and drug activity. The multidisciplinary project here proposed will characterize fundamental mechanisms and signaling pathways deregulated in prostate cancer through the assembly of a prostate cancer interactome, which is an accurate network of transcriptional and post-translational molecular interactions. Importantly, we will utilize reverse-engineering approaches that are unbiased and encompass the entire genome. We will use gene expression profiling of samples from different mouse models in order to have a representation of all the stages of the disease. This novel mouse to human paradigm will allow distinguishing the “drivers” of prostate cancer from the large number of “passenger” genes whose expression is coincidentally rather than causally altered in cancer progression. Key regulators will then be validated by expression analyses in mouse and human prostate cancers tissue micro-arrays to assess their relationship to disease aggressiveness and outcome. Finally, interrogation of this interactome will allow the identification of novel druggable targets for prostate cancer therapy. Candidate targets will be identified focusing first on those genes that can modulate particular signaling pathways deregulated in prostate cancer, and second on candidate targets that may induce tumor-cell specific apoptosis. Next, we will validate the expression of these candidate targets in human prostate cancer specimens, thus allowing the identification of the individuals that might benefit from specific interventions. The integrated in vivo modeling and bioinformatics study on prostate cancer proposed here will improve the capacity of the European host institution of conducting cutting edge research on this area and should constitute a significant step forward in the European leadership in the field.

Keywords: health sciences,prostate cancer,systems biology,systems pathology,bioinformatics algorithms,molecular interactome,genetically engineered mouse,molecular targets
Pronouns of Medieval Italian Dialects (PROMID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-01
End date: 2011-06-30
Duration (months): 15.0
Total project cost (EUR): 173403.2
EU funding (EUR): 173403.2
Participants: 1
Project status: CLOSED

This project will examine the pronominal systems of Medieval Italian Dialects on the basis of a scrutiny of 13th and 14th centuries texts. It will represent a significant contribution both to the field of Italo-Romance linguistics and, more widely, to the general linguistics community, by adopting an interdisciplinary approach that interfaces traditional philological and dialectological studies with recent advances in morphological and syntactic theory. The data will be firstly sifted on the basis of rigorous philological criteria in order to exclude from the sample of texts those containing misleading phenomena due to the influence of other (prestigious) dialects or the intervention of later copyists. Then the data will be classified and stored into a relational database, which allows efficient and rapid comparison of morphological and syntactic variation. In particular, the project will exploit an innovative data management system based on an inventory of specific tags that capture unambiguously the grammatical properties of each sentence. This allows us to organize the data according to a set of linguistic features so as to maximise the possibilities of comparison and enhance the capacity to find meaningful correlations among morpho-syntactic phenomena. On the basis of these features, this system will indeed retrieve not only a specific phenomenon in different texts, but also its specific characteristics and the co-occurrence of distinct phenomena/properties. The database will finally provide an organized set of data that can be readily retrieved and compared in order to allow the extraction of material for articles, presentations, and a comprehensive grammar of MID personal pronouns to be prepared during the last phase of the research.

Keywords: humanities,language sciences,dialectology,comparative linguistics,grammar,syntax,morphology,philology,romance languages,italian language