Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Assessment of Jellyfish Socioeconomic Impacts in the Mediterranean: Implications for Management (JELLYPACTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2020-08-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Social and scientific concern about jellyfish (JF) blooms has risen over the past decades. This concern is reflected on the number of reports on JF; since 1941 the number of scientific publications on JF has doubled each decade, whilst news reports have increased by over 500% over the past two decades. Aggregations of JF can cause multitude of problems for different sectors of society; including the fishing industry and tourism. There is no doubt that the combination of a growing human population and the increasing use of the marine environment will lead to higher encounter rates between JF and humans. To add to the concern, there has been a heated scientific debate on whether JF populations might be on the rise. However, regardless of whether JF populations are increasing, there are no easy solutions to manage all the problems associated with JF blooms. Therefore, there is an urgent need to focus research objectives towards understanding the potential of a suite of management strategies to tackle current impacts of JF over ecosystem services. There are many existing strategies for managing JF blooms however, these are mostly economically expensive and thus, there is a need to evaluate whether the costs of implementing particular management policies will offset the costs of JF impacts. In order to device cost-effective management strategies, a focus on the interdisciplinary nature of JF impacts that includes ecological, social and economic aspects such as the associated loss of people’s wellbeing is of critical importance. Unfortunately, there is a knowledge gap on the socioeconomic impacts of JF and estimates are sparse and qualitative. The project proposed here has the overall goal to further the knowledge of the existing interactions between jellyfish and society by assessing the economic and social impacts stemming from their presence and the integration of this newfound knowledge into adaptive management policies.

Keywords: jellyfish,socioeconomics,impacts,integrated coastal zone management,wellbeing,valuation,policy,mediterranean,mitigation measures,adaptability
Defining the Oligodendrocyte Lineage in Multiple Sclerosis Lesions by Single Cell RNA-Sequencing (MuSeq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

At which stage in oligodendrocyte (OL) differentiation does remyelination in Multiple Sclerosis (MS) lesions fail? Answering this is essential for developing new therapies for progressive MS patients in whom failed remyelination leads to neurodegeneration. Current neuropathological technologies using antibody labelling are insufficiently sensitive to detect each of the possible stages at which the process might fail. In MuSeq, I will therefore use single cell and single nuclear RNA-sequencing (scRNA-seq and snRNA-seq) technologies to define the stages of OL differentiation in human post-mortem brain in healthy and in MS tissue available to me from the Edinburgh tissue bank. By overcoming the problems of sensitivity and revealing the degree of heterogeneity within lesions, this innovative and multidisciplinary project will for the first time unravel the patterns of OL differentiation and its failure in human MS lesions. This in turn will generate a new and powerful classification system for MS lesions based on their regenerative potential, and generate an open-access web database for future functional studies beyond this project and laboratory. By identifying those key roadblocks that need to be overcome to promote remyelination, MuSeq will lay the foundations for rational therapeutics to improve the repair mechanisms of individual MS patients and thus promote European scientific excellence. The project will be carried out under the guidance of leading experts at the University of Edinburgh with a secondment at the Karolinska Institute (Stockholm), a world-leading medical research institution. Results from the project will be used to raise public awareness on the importance of innovative MS research. I have the track-record, expertise and motivation to drive this IF project, and this will equip me with the extra skills I need to pave the way for my future career as an independent researcher in the field of translational neuroscience in Europe and internationally.

Keywords: multiple sclerosis,single cell rna sequencing,translational science,brain,neurodegenerative disease,glial cells,oligodendrocyte lineage,differentiation
Responsive Results-Based Management and capacity building for EU Sustainable Fisheries Partnership Agreement- and international waters (FarFish)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Research and Innovation actions
Countries involved: Spain,Iceland,Spain,Norway,Norway,Mauritania,Seychelles,Faroe Islands,Senegal,United Kingdom,Portugal,Morocco,Brazil,Cabo Verde,Denmark,United Kingdom
Call: Advancing basic biological knowledge and improving management tools for commercially important fish and other seafood species (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 5098062.5
EU funding (EUR): 4999960.0
Participants: 26
Project status: CLOSED

The objective of FarFish is to improve knowledge on and management of EU fisheries outside Europe, while contributing to sustainability and long term profitability. 21% of EU catches originate from non-EU waters. These fisheries are often poorly regulated, management decisions are sometimes based on limited knowledge and enforcement capabilities, compliance and trust between stakeholders tend to lack. FarFish will address these shortcomings in a multidisciplinary and innovative way by focusing on six diverse case studies, four in Sustainable Fisheries Partnership Agreement (SFPA) waters and two in international waters. Firstly, FarFish will analyse biological, ecological, technological, economic, political and social impacts of EU fisheries in the case studies to advance knowledge and promote sustainable and profitable exploitation. Secondly, introduce Results-Based Management approaches and new decision support tools into these fisheries and test their applicability in collaboration with stakeholders. Thirdly, build capacities in fisheries management and related disciplines amongst stakeholders. The results of FarFish will both have immediate and long-term application. FarFish includes a diverse groups of stakeholders, EU and third country fleets representatives, scientists, decision makers, Regional Fisheries Management Organisations (RFMOs), relevant industries and stakeholders from areas outside the case studies but of importance for the EU fleet, forming a platform for future cooperation between EU and third countries. FarFish addresses the work programme by improving knowledge within the relevant fisheries, developing management tools and models, improving professional skills and sharing new findings in correspondence to the priorities of SFPAs, RFMOs and the CFP. FarFish will contribute to sustainable management, resilience and efficiency in the seafood value chains, increase European food security, boost long-term profitability and promote jobs.

Keywords: responsive fisheries management system,results based management,sfpas,rfmos,decision support tools,stock assessment,tuna,mixed fisheries,sustainability,food security,tutor web
ACTIVATING INCLUSIVE GROWTH IN RAILWAY SMES BY WORKPLACE INNOVATION (RailActivation)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Italy,Spain
Call: Workplace innovation uptake by SMEs (H2020-INNOSUP-2019-04, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 298524.25
EU funding (EUR): 298524.25
Participants: 6
Project status: SIGNED

Railway Industry is complex because of the high added value of the services and supplies that involves the market in itself. Different standards apply to the industry along the whole value chain, with different technical standards, making difficult the digitalization process of the railway industry due to the particularities associated to it. The main objective of RailActivation Project is to create and piloting a rail business and organisational mechanisms for the uptake of workplace innovation by SMEs from the railway sector as part of an Open Innovation ecosystem. To this end, the RailActivation project will work on the development of a new mechanisms and tools based on proven principles to anticipate the effects of the digitalisation on the railway sector and designing innovation process transformation for the EU Railway Industry from the inside out by actively reimagining the entire business around the customer, enabling employees to be the catalyst for change. In order to address this objective, the specific objectives of the project are: (i) Looking at existing tools, identify and exchange best practices, (ii) Suggest a new pilot scheme, including context based, long term mechanisms to support the uptake of workplace innovation by the SMEs, (iii) test pilot scheme, (iv) create an interregional network, (v) raise awareness and dissemination of the need for Workplace Innovation, and (vi)Workplace Innovation recommendations of the benefits of these innovations. The RailActivation will be the first business model adapted to its use in the rail industry and turn every worked into a committed worker through the uptake of workplace innovation by SMEs; thus, enabling inclusive growth in railway SMEs.

Keywords: open innovation,workplace innovation,working smarter,eu policy,social innovation,culture,flexible,strategic,product market orientation,well being,skills
EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS (ERA4TB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Spain,Germany,Spain,Italy,Italy,Germany,Germany,Spain,Italy,Ireland,Switzerland,Sweden,Sweden,Belgium,Belgium,Latvia,France,France,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: AMR Accelerator programme Pillar B: Tuberculosis drug development network to accelerate and validate scientific discoveries and advance the R&D pipeline of new and innovative agents to address the global tuberculosis epidemic (H2020-JTI-IMI2-2018-15-two-stage, 2018)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 207963891.0
EU funding (EUR): 89815600.0
Participants: 33
Project status: SIGNED

The European Regimen Accelerator for Tuberculosis (ERA4TB) has the explicit goal of developing a new combination therapy to treat all forms of TB starting from ~20 leads and drug candidates provided by EFPIA. Since details of these are as yet unavailable, we will implement an agile drug development algorithm that entails profiling and portfolio construction. Profiling involves characterisation and ranking molecules in preclinical studies comprising in vitro drug combination assays, hollow fiber and single cell analysis, innovative murine and non-human primate models, PK/PD studies, combined with biomarker discovery and non-invasive NIR or PET/CT imaging to monitor disease progression and response to treatment. Modelling, simulation and artificial intelligence tools will help progress compounds from early preclinical to clinical development and to predict drug exposure, human doses and the best combinations. After extensive preclinical profiling, selected compounds will enter portfolio development for first time in human tests and phase I clinical trials in order to ensure that they are safe, well-tolerated and bioavailable with negligible drug-drug interactions. If needed, formulation studies will be conducted to improve pharmacological properties. ERA4TB has assembled the best expertise and resources available in Europe, to build a highly effective and sustainable drug development consortium with a flexible and dynamic management system to execute the profiling and portfolio strategy, aided by clearly defined go/no-go decision points. The expected outcome of ERA4TB is a series of highly active, bactericidal, orally available drugs to constitute two or more new combination regimens with treatment-shortening potential ready for Phase II clinical evaluation. These regimens will be compatible with drugs used to treat common comorbidities, such as HIV-AIDS and diabetes, and should impact UN Sustainable Development Goal 3, namely, ending TB by 2030.

Keywords: tuberculosis,pan tb regimen,preclinical development
Process Intensification through Adaptable Catalytic Reactors made by 3D Printing (PRINTCR3DIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Norway,Norway,France,France,France,France,Czechia,Portugal,United Kingdom
Call: New adaptable catalytic reactor methodologies for Process Intensification (H2020-SPIRE-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 5493891.0
EU funding (EUR): 5493889.0
Participants: 15
Project status: CLOSED

Catalytic reactors account for production of 90% of chemicals we use in everyday life. To achieve the decarbonisation of European economy and comply with the 20-20-20 target, resource utilization and energy efficiency will play a major role in all industrial processes. The concept of PRINTCR3DIT is to employ 3D printing to boost process intensification in the chemical industries by adapting reactors and structured catalysts to the requirements of the reaction. This manufacturing technique is particularly useful in reactions where diffusion, mixing and/or heat transfer are limitations against reaching higher performance. The utilization of the concept of 3D printing will also reduce the resource utilization of reactor and catalyst manufacture, energy consumed (< 15%) and transportation. The rationale of using 3D printing will follow a generic and systematic structure for implementation. The methodology will be applied to three markets of fine chemicals, specialty chemicals and fertilizers, ranging from few tons to millions of tons of production per year. This demonstrates the enormous versatility of 3D printing for reactor and catalyst designs that cannot be improved with traditional building and design tools. For all these processes, the challenges to be solved are thermal management, innovative reactor design and flow distribution. These examples will provide realistic data in different markets to delineate business case scenarios with the options of new integrated plants or retrofitting for large-scale applications. Application of cutting-edge 3D printing to catalytic reactors will foster higher productivity, a more competitive industrial sector and higher value jobs in Europe - keeping leadership in such a challenging arena. PRINTCR3DIT is a joint effort between world-leading industries (4), innovative SMEs (4), R&D institutes (4) and a university that aim to accelerate deployment of a set of products to the market.

Keywords: 3d printing,process intensification,heterogeneous catalysis,cfd modelling,structured catalyst
Early Stage Sensing of Fouling in Membrane Water Treatment (ESSENS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-10-01
End date: 2018-03-31
Duration (months): 18.0
Total project cost (EUR): 149760.0
EU funding (EUR): 149760.0
Participants: 1
Project status: CLOSED

UN-Water has recently warned that in only ten years' time, by 2025, water scarcity will be affecting 1.8 billion people, with two-thirds of the world population possibly living under conditions of water stress. There exists, hence, a strong need to rigorously manage drinking water resources. The production of potable water by membrane water treatment systems is relatively economic and benign. 80 million m3 of potable water are already produced nowadays using membranes. However, the efficiency of membrane water treatment processes may severely be impeded by a phenomenon known as "membrane fouling". Hereby, organic matter present in the water to be treated adsorbs on the surface of the porous membrane filters, resulting in the build-up of a surface layer which then increasingly closes the membrane pores and, hence, dramatically diminishes the potable water production. If detected at an early stage, such fouling could be counteracted by adequate process operating conditions. Once a rigid fouling layer is formed, however, chemically aggressive membrane cleaning procedures need to be employed with respective negative environmental impact. ESSENS proposes a monitoring device that outperforms existing fouling detection techniques and allows optimizing both fouling prevention and membrane cleaning cycles. The result is a significantly more efficient and sustainable membrane water treatment processes, enabling a greatly improved management of the drinking water production.

Keywords: fouling,membrane filtration,surface sensitive monitoring techniques
Enrichment of Components at Interfaces and Mass Transfer in Fluid Separation Technologies (ENRICO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: CLOSED

Techniques for separating fluid mixtures are important in many industries like the chemical and pharmaceutical industry. The most relevant of these separation techniques, like distillation and absorption, are based on mass transfer over fluid interfaces. Results from molecular thermodynamics, which have recently become available, show that for many industrially important mixtures a strong enrichment of components occurs at the fluid interface. There is a striking congruence between shortcomings of the present design methods for fluid separations and the occurrence of that enrichment. It is the central hypothesis of the present research that the enrichment leads to a mass transfer resistance of the fluid interface which has to be accounted for in fluid separation process design. The fact that it is presently neglected causes unnecessary empiricism and inconsistencies in the design. ENRICO will advance the knowledge on the enrichment of components at fluid interfaces using a novel combination of two independent theoretical methods, namely molecular simulations with force fields on one side and density gradient theory coupled with equations of state on the other. This will enable reliable predictions of the occurrence of the enrichment and its magnitude. These results will be combined with the theory of irreversible thermodynamics to establish for the first time a model for the mass transfer resistance of the interface due to the enrichment. On that basis, a new approach for designing fluid separation processes will be developed in ENRICO, which will lead to more efficient and robust designs. The theoretical results will be validated by experiments from laboratory to pilot plant scale, and the benefits of the new approach will be demonstrated. ENRICO will thus establish a link between molecular physics and engineering practice. The results from ENRICO will have a major impact on chemical engineering world-wide and change the way fluid separation processes are designed.
Multiple cellular screens using microfluidic droplets (Multiscreen)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France,France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Although some biotechnologies have made huge strides e.g. in automation, data generation, or biochemical methods, cell handling still uses antiquated methods that limit the scale at which assays can be performed. Our ERC-funded microfluidics work has lead to cutting-edge microdroplet manipulation tools for cell handling: While working with 3D cell cultures, we have recently shown that we can obtain great increases in both throughput and detail, while reducing the sample use and the machine footprint. In addition to these quantitative leaps, the microfluidic format also allows qualitatively new biological constructs to be explored by making significant steps towards the organ-on-a-chip framework. The current project therefore aims to show how the technologies developed in our lab can function together in an integrated cell screening platform. This will require demonstrating a convincing proof of concept of the hardware, software, and workflow, in addition to demonstrating the added value to different industries.

Keywords: microfluidics,drug screening,bio engineering,3d cell culture