Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Accuracy Service Harnessed Trusted Application and Governance (HASHTAG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Netherlands,Serbia,Germany
Call: Designing space-based downstream applications with international partners (HORIZON-EUSPA-2023-SPACE, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 1266398.93
EU funding (EUR): 995503.0
Participants: 6
Project status: SIGNED

The growing introduction of automated or even autonomous machinery on farms makes the need for good quality data more critical. Moreover, the demand is increasing to log the outputs of those machines for analysis, documentation and compliance. However, current datafiles sent to, or retrieved from machinery lack quality standards. They cannot be certified because any guarantee on the integrity of the used data and workflow is missing. HASHTAG is therefore leveraging space assets and services to safeguard the reliability of data ensuring trusted application and governance. Within a period of two years, three building blocks will be developed to proof our concept: 1. Standardising protocols, logging and verifying prescribed tasks using machine data flows to assure as-applied maps are trustworthy. 2. Standardising the processing of high quality EO data from Copernicus into prescription maps. 3. Using Galileo’s High Accuracy Service and Navigation Message Authenticator in a GNSS receiver to provide trusted and accurate machine positioning. Integrating these components will result in a workflow capable of generating a transparant and authenticated data chain of EO data to as-applied maps. This is relevant for current reality, where food production and processing are international businesses with ingredients from around the world, governed by food standards and environmental regulations. Our solution, deploying space assets, can be used anywhere in the world, hence leveraging European knowledge and expertise to enable the next level of sustainable and regenerative farming. International partners from Serbia are included and use cases in Brazil, Ukraine and Indonesia will be explored. HASHTAG will reach out to standardisation initiatives in agritech to promote its results and increase impacts. The specific advantages that the European space infrastructure offer, are important to develop globally acceptable and affordable private and public uptake of our space assets.

Keywords: has,osnma,galileo,copernicus,agriculture,integrity,trusted,fair
Roles of maize PIP2 aquaporins in the structural organization of the cell (PIPContactSite)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-10-31
Duration (months): 29.0
Total project cost (EUR): 200600.92
EU funding (EUR): 200600.92
Participants: 1
Project status: CLOSED

Plasma membrane (PM) Intrinsic Proteins (PIPs) are aquaporins that facilitate the diffusion of water through cell membranes. By regulating PIP activity, plant cells adjust water permeability rapidly and reversibly. PIP PM lateral diffusion is affected by the cell wall and actin. Also, PM-located PIPs interact with VAP27s at the endoplasmic reticulum (ER)–PM contact sites (EPCS). Evidence suggests that PIPs get organized in interaction with other cellular structures. However, the functional relevance of these interactions has not been extensively studied. The PIPContactSites project's main goal is to understand whether ZmPIP2s mediate PM interaction with other cellular structures (ER, cytoskeleton) and elucidate the physiological relevance of the contact sites under salt stress conditions. Our hypothesis is that PIP2 interactions on EPCS and with the cytoskeleton facilitate an efficient response to stimuli by participating in the structural organization of the cell. Our strategy integrates cutting-edge technologies for genome edition (CRISPR/Cas9) and real-time monitoring of interactions (split Fluorescence-Activating and absorption Shifting Tag) with advanced microscopy technologies (i.e., confocal super-resolution and Correlative Light and Electron Microscopy). The originality of this project is to consider PIPs as multifunctional proteins: channels and scaffold proteins. The MSCA fellowship, the great intellectual environment, the infrastructure and the administrative support at the LIBST-UCLouvain, the research and project managing experience of Prof. Chaumont, and my background in molecular biology will synergistically promote the success of the project. The host group will benefit from hosting an independent, creative, and highly skilled scientist. And I will gain experience and networking opportunities to shape my long-term objective of becoming a group leader.

Keywords: endoplasmic reticulum plasma membrane contact sites,cytoskeleton,aquaporin,plant cell
III-V seMiconductor on sILicon nano opticaL amplIfier for signal regenerAtion and coMPuting (MILLIAMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Decreasing both power consumption and footprint of optoelectronic devices has been a long term goal for nanophotonics. MILLIAMP aims at the demonstration of the proof of concept of a novel type of integrated semiconductor optical amplifiers presenting performance in terms of compactness, power consumption and nonlinearity, fulfilling the needs for on chip communications and all-optical neural networks. Our invention stems directly from the work achieved on nanolaser diodes integrated on Si photonic circuit during the ERC consolidator project HYPNOTIC. During the project, technical activities will be focused on the development of the device for two user cases: optical regeneration of high bit rate signals and the demonstration of a sigmoid activation function for neuromorphic computing. The device will complete the portfolio of optoelectronic nanocomponents developed in the PI's team. We aim at exploiting this technology by creating a spin-off company which will offer solutions for systems in package communications. MILLIAMP has for objectives to achieve a market study and determine a business model for the future startup. Our goal will alos be to strengthen the intellectual property and to establish partnerships with microelectronics companies.
«My moral and civil commitment»: Giorgio Bassani's correspondence with worldwide intellectuals. (WorldWideBassani)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-04-30
Duration (months): 32.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

WorldWideBassani project proposes to study and analyze, for the first time, the extraordinary material represented by the letters exchanged by Giorgio Bassani with foreign intellectuals, between 1948 e 1979, preserved in the Giorgio Bassani Heirs Archive in Paris. Thanks to my previous studies on Bassani's works the heirs have authorized me to study and publish the correspondence. The works of Giorgio Bassani (1916-2000) are now considered one of the highest literary reflections on the theme of Jewish persecution and the Shoah, and are read and studied increasingly all over the world. Writing after the end of Second World War, in one of the most difficult periods in the history of humanity, the author initiates, with exceptional anticipation of the times, a profound reflection focused not only on the need to bear witness to the atrocities of persecution, but also on the duty to refound a society based on peaceful coexistence. Among Bassani's correspondents we find names of important intellectuals of the twentieth century, such as Cecil Roth (English historian of Jewish origin), Hans Nilsson-Ehle (Swedish linguist), Juan Rodolfo Wilcock (Argentine scholar), Francis Ponge (French poet), Warren Penn Robert (American writer), Rolf Rheiner (German politician and former SS). In this dialogue, crucial issues are addressed: the elaboration of the traumatic past of the Shoah, but also the crisis and disaster of the old world and the rebirth of a “Europe of the peoples”. These documents, unpublished and unknown to scholars, will offer a new perspective on the evolution of the author's thought and on the international, collettive debate on the re-elaboration of the tragedy of persecution, as well as on the construction of a European cultural identity. Thanks to the dissemination and exploitation tools provided by the project (see 2.2), this work will offer a new interpretative model to the entire international community of scholars, decision-makers and the broader public.

Keywords: holocaust studies giorgio bassani european history european identity epistolary studies
Global Amyloid Mapping: Solving Amyloid Nucleation by Deep Mutagenesis (GLAM-Map)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999008.0
EU funding (EUR): 1999008.0
Participants: 1
Project status: SIGNED

Amyloid fibrils form and precipitate in more than 50 incurable human diseases, including Alzheimer’s and Parkinson’s disease. All proteins may be able to form amyloids, at least under certain circumstances. However, aggregation is actually rare as the process of amyloid formation is controlled by a high kinetic barrier: protein sequences have to cross a free energy barrier to nucleate transition states which then seed irreversible fibril formation. Short-lived transition states are extremely challenging to study using biophysical methods. We have recently developed a massively parallel genomics approach to quantify the rate of aggregation of thousands of protein sequences. We also have evidence that, by quantifying the interactions between mutations, we can capture the key interactions between residues in the transition state. Here, we will unleash the potential of this approach by targeting the following aims: 1) Map the impact on amyloid nucleation of all possible mutations in >60 human and functional amyloids - generating reference atlases for clinical variant interpretation 2) Build an energetic and structural model of the transition state of disease-associated amyloids 3) Uncover sequences across the genome that nucleate amyloids in response to environmental stress This project will uncover the rules required to understand, predict and engineer amyloid formation. By identifying the mutations that do and do not lead to amyloid formation, we will reveal which variants accelerate aggregation and cause disease. We will also address one of the most important questions in the field, i.e. identifying the interactions established in the transition states of amyloid nucleation, guiding the development of therapeutic approaches in amyloid diseases, including the worst kinds of dementia. Finally, our results will feed a new generation of models and predictors of protein aggregation to employ for disease variant interpretation and the synthetic design of novel proteins.

Keywords: deep mutagenesis,protein aggregation,amyloids,genetic interactions,random sequences,kinetic barrier,dementia,clinical variant interpretation,variants of uncertain significance vus
Reignite Multilateralism via Technology (REMIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,Romania,Germany,Belgium,Italy,Estonia,Finland,United Kingdom
Call: Global governance for a world in transition: Norms, institutions, actors (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2628125.85
EU funding (EUR): 2628125.85
Participants: 9
Project status: SIGNED

The REMIT project aims to Reignite Multilateralism via Technology. Multilateralism is under attack and the EU is caught between the U.S. and China. While there are many ways that the decline in multilateralism affects the EU, none is more troublesome than rivalries in technology. Firstly, because of the sector’s impact on economic competitiveness and the size within economies that tech occupies. Secondly, tech is important to national security and future threats, including threats to democratic principles. Thirdly, technology is crucial to the solutions for global challenges. REMIT will create knowledge that generates policy recommendations and strategies that support the EU in reconceptualizing multilateral governance in four crucial policy areas: digital, biotechnology, security and defense, and financial technologies. REMIT researchers create this knowledge by employing the Advocacy Coalition Framework (ACF) to specific subsystems. The policy subsystem is the ACF’s unit of analysis. It is characterized by three components: the policy problem or issue; the scope of actors seeking to influence that policy; and a territorial domain or authority for policymaking. REMIT experts focus on subsystems that emerge from their expertise, analyzing the tensions and debates within each as well as defining the EU’s current role. Knowing the status quo makes the next step possible—to extrapolate ideas and to suggest pathways forward. In innovative scenario testing workshops with EU officials, important regional groupings (e.g., Mercosur, ASEAN, and African Union) and national officials, REMIT will develop policy recommendations that will give a remit to reignite multilateralism via technology. A reigniting that not only reacts to China’s rise as a systemic technology rival or Russia’s rise as a technology abuser or the dominance of large U.S.-based digital platforms, but that sets a clear vision for the future—one in which Europe plays a leading role.

Keywords: multilateralism,critical technology governance,geopolitics and technology governance,economic,social and environmental aspects of technology governance
Cancer Prevention at Work (CPW): Occupational health surveillance in the implementation of prevention of infection-related cancer. (CPW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Italy,Romania,Slovakia,Denmark,Spain,Germany,Czechia
Call: Improving and upscaling primary prevention of cancer through implementation research (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 5801577.5
EU funding (EUR): 5801577.5
Participants: 19
Project status: SIGNED

Chronic infections represent a major cause of human cancer: on a global scale, they are responsible for an estimated 13% of human cancers. Helicobacter pylori (Hp), Hepatitis C virus (HCV), and Human Papilloma Virus (HPV) are responsible together for 75% of these cases, or 10% of total cancer burden [De Martel et al., 2020]. Occupation health surveillance is mandatory in all European countries: although the mechanisms of its implementation vary between the countries, these programs are in general aimed at diagnosing and preventing work-related diseases. Prevention of occupational cancers has therefore been a component of occupational health surveillance. In recent years, however, there has been a movement towards including in occupational health surveillance aspects of health promotion which are not occupational in a strict sense. This approach stems from several considerations: (i) the contact between the worker and the health professional in charge of the surveillance can be seen as a privileged opportunity for health promotion in general; (ii) through the worker, the health promotion initiative may reach other groups of the population; (iii) because of the periodic nature of the visits entailed by the occupational health surveillance, it is possible to efficiently implement follow-up mechanisms. The conceptual framework of the proposed research is based on the incorporation into on-going occupational surveillance schemes of primary prevention programs against infection with Hp, HCV and HPV. The overarching objectives of the proposed research are: - to conduct a series of pilot projects aimed at assessing the effectiveness (including cost-effectiveness) of incorporating primary prevention interventions against Hp, HCV and HPV into existing occupational surveillance systems in high-risk populations, including its impact beyond the workers directly involved in the pilot projects; - to identify barriers and bottlenecks for the implementation of such interventions. This action is part of the Cancer Mission cluster of projects on ‘Prevention and early detection'.

Keywords: human papilloma virus,hepatitis c virus,helicobacter pylori,chronic infections,occupation health surveillance,worker,primary prevention,cancer,chronic infections
Assessing Human Health Impacts of Maritime Air Pollution (MARHEALTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

While local air pollutants are well-known to have detrimental impacts on human health, we lack a complete understanding of the economic costs imposed by the negative health effects from exposure to maritime air pollution. In addition, because health effects are uncertain and likely to be heterogeneous due to the non-uniform population distribution and location of ships, it is difficult to design efficient policies to mitigate maritime emissions. Nevertheless, the transition to a net-zero emissions economy will require the implementation of policies to curb emissions in the maritime sector. By combining detailed Norwegian administrative data with highly granular geo-referenced data on shipping routes and air pollution, MARHEALTH aims to quantify the health effects of maritime air pollution and to assess the effectiveness of pollution mitigation policies in the shipping sector. These objectives will be addressed through three specific subgoals: 1) Generate high-quality data sets by combining administrative health and socio-economic data on individuals with highly granular geo-referenced data on shipping routes of all container and passenger vessels and satellite- and ground-based environmental data on air quality and weather. Further, I will collect and merge information on the transition from fossil fuel-operated to electrified passenger ships. 2) Empirical analysis of the health impacts of maritime air pollution by estimating causal impacts of pollution from ports. Linked data on health outcomes with socioeconomic characteristics of individuals allows me to uncover socio-demographic disparities in the health effects of exposed individuals. 3) Empirical quantification of the benefits of green transition policies in the maritime sector by merging the environmental and individual-level data with information on shipping routes of electrified vessels to econometrically recover causal estimates.

Keywords: air pollution,health impacts,maritime shipping,green transition,applied econometrics
Superconducting germanium-based hybrid bolometers for microwave photon detection (SUGER-BOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

Detecting microwave radiation, down to the single photon level, is a central challenge in modern quantum technologies. In recent years, a promising route has been envisioned, largely inspired by an ubiquitous technique in high-energy photon detection: bolometry. Its principle relies on energy dissipation of incident photons in a thermal detector, the temperature of which is monitored. This calorimetric technique allows for single photon detection in the infrared band or above, but its application to the microwave domain is challenging, since individual photons carry orders of magnitude less energy. However, superconducting nanoscale thermal detectors at millikelvin temperatures have recently shown their great potential for sensing extremely low radiation signals, as well as small instantaneous energy releases. Although still challenging at present, considering the calorimetric detection of single microwave photons emitted by a qubit is within reach. A very recent work demonstrated the single-shot read out of a qubit state, by measuring in situ the magnitude of the readout microwave signal, using a superconducting bolometer. In this project, the researcher will develop and measure nano-bolometers based on silicon-germanium heterostructures, and infer limiting factors in their sensitivity. These bolometers will be co-integrated with germanium qubits to benchmark their performances as compared to standard dispersive detection schemes. The researcher will also push these detectors' sensitivity beyond the state of the art, with the final goal to detect single microwave photons. This will allow for wide-ranging and groundbreaking applications, including alternative qubit readout schemes but also quantum thermodynamics experiments in circuit-QED architectures.

Keywords: quantum detection,calorimetry,bolometry,josephson junction,qubit readout