Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cascade reactions with Zeolites in compartmentalized settings (CaZeo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2499718.0
EU funding (EUR): 2499718.0
Participants: 1
Project status: SIGNED

CaZeo uses zeolites to overcome thermodynamic barriers in cascade processes, instrumentalizing the zeolite micropores to compartmentalize the reaction space. As a pilot case, the endergonic hydrogenation of CO2 to CO inside a small-pore zeolite is coupled to an exergonic homogeneously catalyzed carbonylation of an alkene outside the zeolite, yielding in one step an ester product with a CO2-derived functional group. Critically, undesired alkene hydrogenation is impeded by the narrow zeolite channels. CaZeo’s overall chemical targets include: (i) to re-integrate CO2 into oxygenated compounds, like esters, aldehydes, glycolaldehyde, isoprenol etc., in which at least one oxygenated function is sourced from CO2, via a Reverse Water Gas Shift Reaction to CO, or via selective CO2 hydrogenation to HCHO; (ii) to use zeolites as generators of small, reactive (or even toxic) molecules like isocyanates or isocyanides, starting from safe precursors like N,N-dialkylureas or N-alkylformamides; (iii) to upgrade polyamide-6,6 by ammonolysis and an ensuing zeolite-catalyzed reaction that convergently transforms the N-functionalized molecular mixture to valuable 1,6-hexanediamine. In CaZeo’s conceptual framework, reactions are spatially partitioned and orthogonalized to each other, overcoming the incompatibility conundrum of catalytic cascades and the equilibrium limitations of isolated reactions. In a more advanced development, pore systems with different diameters within one zeolite crystal are used as compartments. Advanced X-ray absorption spectroscopy monitors the monometallic or cooperative bimetallic active sites in the zeolites. The spatial organization is visualized with high-resolution electron and fluorescence micro(spectro)scopies, giving shape to the envisioned compartments. CaZeo provides catalytic technology that is safe and sustainable, recycles nitrogen-containing (waste) polymers to high quality building blocks, and re-integrates CO2 in chemicals.

Keywords: zeolite catalysis cascade reactions,carbon circularity
When keystone species converge: a transdisciplinary study of human-beaver interactions in Atlantic north-west Europe (6000-3000 BC) (KEYCON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-10-31
Duration (months): 30.0
Total project cost (EUR): 288468.0
EU funding (EUR): 288468.0
Participants: 2
Project status: CLOSED

The European beaver (Castor fiber) is central to rewilding schemes in north-west Europe today due to its role as a keystone species. However, its engineering feats are also an increasing source of human-wildlife conflict. While these challenges are unique to our time, prior to near-extinction beavers interacted with humans and their environments for over 10,000 years. Yet, there is little systematic data on these dynamics in the past. KEYCON comparatively investigates the changing interactions between humans and beavers – two keystone species – during the Atlantic period (6000-3000 BC) in Denmark and the Netherlands, across the pivotal transition from foraging to farming and a period of changing climate. Few studies have considered how the critical changes in human land use and subsistence impacted human-wildlife relationships beyond diet. Achieving new understanding of these issues is hampered by the lack of knowledge of how human and wild fauna domains intersected in the past, a lack of focused studies of wild fauna remains, and a persevering anthropocentric perspective on past human-nonhuman relationships. To address these challenges, KEYCON integrates computational ecological modelling and zooarchaeological techniques in a transdisciplinary approach encompassing archaeology, multi-species anthropology, and conservation biology. Utilising the rich yet untapped dataset of prehistoric beaver assemblages from Denmark and the Netherlands, KEYCON provides a novel perspective on human-beaver interactions in the past. Using the resulting insights, KEYCON seeks also to contribute a data-driven, deep-time perspective on current rewilding schemes, the success of which is predicated on how the socio-ecological dynamics between humans and wild animals are addressed, and on robust ecological baselines. Mobilising a unique archaeological dataset, KEYCON will provide essential longue durée data and perspectives on both of these aspects.

Keywords: zooarchaeology computational modelling rewilding hunting farming neolithisation human animal studies multispecies
Fabricating vegan and circular leather alternatives from bio-tech derived cellulose (Fabulose)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Germany,Italy,Slovenia,Türkiye,Austria,Portugal
Call: Biotech routes to obtain bio-based chemicals/ materials replacing animal-derived ones (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-06-01
End date: 2028-11-30
Duration (months): 42.0
Total project cost (EUR): 3498440.0
EU funding (EUR): 3498440.0
Participants: 11
Project status: SIGNED

The Fabulose project seeks to transform the production of animal-free leather alternatives by developing sustainable, circular materials derived from biotech processes. Our goal is to create high-performance, fully biodegradable leather substitutes from bacterial cellulose (BC) and cyanophycin, replicating the properties of traditional leather while reducing environmental impact. By employing advanced fermentation techniques and AI-driven optimizations, we will scale the production of these bio-based materials to meet the demands of industries such as automotive, footwear, and upholstery. To ensure these materials are sustainable throughout their lifecycle, digital tools such as the Digital Twin (DT) and Digital Product Passport (DPP) will monitor, optimize, and track production processes and material performance. This will also support transparency and enable efficient recycling management, aligning the project with circular economy principles. Fabulose will significantly contribute to the European Green Deal by offering alternatives that are not only animal-free but also minimize resource consumption and environmental harm. By focusing on innovation, we aim to enhance Europe's competitive position in sustainable materials, delivering eco-friendly products that meet stringent technical and regulatory standards. The project outcomes will help replace fossil-fuel-based materials with a scalable, environmentally responsible solution, promoting healthier ecosystems and sustainable consumption.

Keywords: biobased animal free leather alternative,circular economy,bacterial cellulose,cyanophycin,demonstration plant
Advancing Circular Economy with Bio-Based Solutions for CO2 & Nitrogen Management & Valorisation (ACORN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Belgium
Call: EIC Booster grant for EIC Pathfinder and EIC Transition grants (HORIZON-EIC-2024-BOOSTER-IBA-01, 2024)
Start date: 2024-11-01
End date: 2026-08-31
Duration (months): 22.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: SIGNED

ACORN researches and develops business models for the commercial and industrial adoption of bio-based products within the Carbon Dioxide and Nitrogen Management and Valorisation Portfolio (CDNMVP) using approaches that are compatible with a circular economy.

Keywords: value,economic,market research,circular economy
Animating Metamaterials using Non-Reciprocity (ANIMETA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2936758.75
EU funding (EUR): 2936758.75
Participants: 1
Project status: SIGNED

Living materials such as cells, tissues and simple organisms are animate. They autonomously and adaptively navigate their environment and are resilient to damage. Can we take inspiration from Nature and create synthetic animate materials? This dream has now become tangible thanks to major progress in the field of mechanical metamaterials. Metamaterials are composites that exhibit exceptional properties by leveraging geometric effects within their architecture. For example, they exhibit on-demand shape-changes and guide waves unidirectionally. Such functionalities are extremely promising to achieve animacy: pairing unidirectional waves with shape-changes can power locomotion—a crucial aspect of animacy. Yet, the locomotion of such metamaterials remains poorly understood and we lack design principles for their design and control. Therefore, metamaterials cannot locomote in complex and unpredictable terrains. I propose to overcome these limitations by introducing a new class of shape-changing metamaterials that are non-reciprocal. I will add robotics to the metamaterials toolbox by using distributed sensors, actuators and feedback control to break mechanical reciprocity, viz. Newton’s third law. These non-reciprocal metamaterials are described by asymmetric matrices and tensors and display unidirectional patterns of shape-changes. I will harness these patterns to create three-dimensional metamaterials that can autonomously roll, crawl and jump, and that display optimal locomotion performances in complex and unpredictable terrains. Just as living materials have deeply integrated and distributed functions, metamaterials will achieve animacy by interweaving shape-changes and non-reciprocity. ANIMETA will blur the boundary between metamaterials and robotics, provide new insights into metamaterial design and pattern formation in a distinctive setting where reciprocity is broken and will bring about new concepts for a new generation of distributed robots.

Keywords: mechanical metamaterials,non reciprocity,robotic metamaterials,odd elasticity,robophysics
Disability versus Difference over Development in the Autisms (AUTISMS-3D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Italy,United States
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999750.0
EU funding (EUR): 1999750.0
Participants: 2
Project status: SIGNED

Autism is an early developing condition diagnosed on the basis of difficulties in the domains of social-communication and restricted repetitive behaviors. However, the single label of ‘autism’ masks a large degree of heterogeneity at multiple scales, from genome to phenome, and may not signal differential needs and services required for some types of profoundly affected individuals. In order to better understand autism and develop more impactful ways to facilitate positive outcomes at an individualized-level, we need better models that help to explain how autism may be differentiated in meaningful ways that help explain variability in developmental paths, responses to treatment, and differential underlying neurobiological mechanisms. This research program develops and tests the AUTISMS-3D model – disability versus difference over development - as a first-level major distinction for explaining heterogeneity within the autism population. AUTISMS-3D postulates that the major first-level split within the autism population is between subtypes described by profound disability versus difference in developmental outcomes. Stratification models using standardized clinical measures of intellectual functioning, language, and adaptive behavior will be used to predict ‘disability’ versus ‘difference’ subtypes. These stratification models are based on highly reproducible data-driven clustering analyses from very large phenotypic datasets. We will then test how the subtypes may develop differently with analyses of big clinical longitudinal datasets and also within the context of early intervention. Finally, we will test the subtypes for neurobiological differences via neuroimaging (MRI, fMRI, DTI) and electrophysiological (EEG) and gaze phenotypes (e.g., eye tracking) under static and naturalistic viewing conditions. The research will help refine our understanding and concepts of autism and will be an important next step on the path to precision medicine for the autisms.

Keywords: autism,heterogeneity,precision medicine,neuroimaging,electrophysiology,eye tracking,early intervention
Addressing therapy resistance in cancer: See it, dose it, treat it! (NTx)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Therapy-resistant solid tumours represent a critical gap in precision oncology: despite advances in surgery, chemotherapy, immunotherapy and targeted agents, relapse driven by resistant cell populations remains the primary cause of treatment failure across major cancers. Our UK-based SME, Nuclide Therapeutics, proposes to tackle this unmet need with NTx-11, a first-in-class radiotheranostic that enables clinicians to see therapy resistant tumours, tailor individual doses for patients and effectively treat the most challenging cancers. NTx-11 uses a dual-isotope approach (iodine-124 for PET imaging and dosimetry; iodine-131 for targeted β-therapy) to identify and eradicate ALDH1A1-positive, therapy-resistant tumour cells—a mechanism shared across prevalent malignancies such as non-small cell lung cancer, ovarian, pancreatic and colorectal cancers. In doing so, our solution advances radiotheranostics beyond the limited receptor-driven indications currently served, and aligns with the European Cancer Mission’s goals of expanding precision oncology and improving outcomes. Over the two-year project horizon we will: (i) progress NTx-11 from TRL 6 through GMP manufacturing to first-in-human evaluation; (ii) establish a manufacturing and distribution network for iodine-labelled radiopharmaceuticals; and (iii) build the foundations of a platform pipeline into multiple high-burden, resistant tumour types. The project will deliver quantifiable benefits for patients (planned stratified treatment, improved survival, greater quality of life), for clinicians (image-guided dosing, enhanced decision making) and for healthcare systems (reduced ineffective treatment cycles, lower toxicity, improved cost-efficiency). With private investment already secured and global radiopharmacy infrastructure maturing, this initiative is well-timed to accelerate deep-tech healthcare innovation while reinforcing EU strategic autonomy in radionuclide therapy.

Keywords: cancer,radiotheranostics,therapy resistance
Walls of Secrecy and Silence in the Human Organ Trade: Facilitating, Concealing and Laundering Illegal Transplants (ORGANTRADE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1499955.0
EU funding (EUR): 1499955.0
Participants: 1
Project status: SIGNED

The organ trade is a relatively new but neglected crime that is proliferating globally. The trade is prohibited universally, yet, the growing gap between organ supply and demand has led to an ‘illegal’ organ market that converges with altruistic organ procurement systems. In this market, growing numbers of desperate patients from the global north travel to the global south to buy organs, often returning with severe medical complications. Similarly, the growing global economic divide and the rise in conflicts and natural disasters are subjecting increasing numbers of vulnerable organ sellers to physical, psychological and financial exploitation on the organ market. Preliminary scholarly work increasingly suggests that this trade is embedded within medical/legal institutions. There is however a critical lack of research and knowledge on how the medical sector, such as hospitals and clinics, and other legal businesses facilitate, conceal and launder illegal transplants. This proposed research aims to understand how, where and why medical/legal businesses facilitate, conceal and launder illegal transplants and assesses the implications for anti-organ trade responses. This project addresses these knowledge gaps through an innovative research program that combines online research, fieldwork and research of the most recently prosecuted cases across the global north and south. It is guided by a unique conceptual framework that combines notions from criminology, transplant medicine and medical ethics. By doing so, this project generates a potentially ground-breaking line of research that radically departs from popular portrayals of the trade as an ‘external’ organized crime and that advances our understanding of the trade as a socio-medical problem that is nested within medical/legal institutions. Insights will be crucial for scientists, policymakers, transplant societies and law enforcement to develop inventive solutions to prevent and disrupt illegal organ transplants.

Keywords: organ trade,transplant bio medicine,medical ethics,white collar crime,organized crime
INTra Abdominal Pressure Monitoring and Warning System (INTAP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Türkiye
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Peritoneal dialysis (PD) is a life-saving treatment for kidney failure patients, but it lacks real-time monitoring capabilities. This can lead to complications and suboptimal outcomes for patients. Allezyum is tackling this challenge with its innovative PD monitoring system, INTAP. INTAP measures critical parameters like intra-abdominal pressure, providing healthcare providers with real-time data to personalise treatment plans and prevent complications. This translates to improved patient outcomes, reduced healthcare costs, and empowered PD patients who can manage their condition more effectively. Allezyum's technology disrupts the stagnant PD market, offering the potential to transform patient care globally. The company is led by a team with proven expertise in medical device development, engineering, and business leadership. Allezyum seeks EIC Accelerator grant to finalise regulatory approvals, launch clinical trials, and scale production. This grant will be instrumental in revolutionising PD therapy worldwide.

Keywords: periton dialyses,monitoring,intraabdominal pressure measurement,intraabdominal pressure mapping,warning,wearable device,7 24 keep watching
Bees As Sensors of Ecosystem States (BASES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Bulgaria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2100000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: SIGNED

Using Bees As Sensors of Ecosystem States helps business evaluate their environmental dependencies and impacts. The global biodiversity crisis, driven largely by anthropogenic activity such as deforestation, pollution, and climate change, poses significant threats to the ecosystem services that underpin human society. According to the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), we are witnessing an unprecedented rate of species extinction, with far-reaching consequences for the environment and human wellbeing. As the world grapples with these challenges, there is a growing demand for accurate, localised biodiversity data that can guide conservation efforts and inform policy decisions. This need is reflected in an increasing focus of policymakers on stimulating efforts of various stakeholders to better understand their interrelations with nature. Traditional methods are often not scalable enough to achieve sufficiently widespread adoption, however scientific advances in the last few decades offer novel approaches that complement traditional approaches and overcome their scalability limitations. Pollenity’s unique approach involves using honeybees as biosensors to monitor biodiversity across various ecosystems relevant to businesses that strive for sustainable practices, as well as evaluate the state of ecosystems in terms of the presence of persistent organic pollutants, pesticides and other threats to ecosystem resilience . By analysing pollen collected by bees, we can assess the presence of different plant species, detect invasive species, and monitor changes in biodiversity over time. Our solution leverages novel molecular methods and other state of the art analytical tools to offer accessible means for collecting site level data to understand the state of ecosystems.

Keywords: biodiversity esg environment