Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SUSPension ENvironment for CEll culture (SUSPENCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Large-scale production of cells is essential for basic research, disease modelling and drug testing. However, scalability and standardization in cellular manufacturing are still major challenges: when large numbers of cells are required, conventional two-dimensional (2D) culture strategies, mainly based on manual, space- and labour-intensive interventions, are practically and financially unsustainable. Dynamic suspension allows large-scale production of cells, but current solutions on the market suffer from limitations in terms of cells damaging and potential contamination (stirred tank bioreactors) or high cost and complexity (rotating bioreactors). The SUSPENCE solution is a microgravity perfusion bioreactor, a highly innovative technological system that keeps cells in suspension in the culture chamber, allowing them to grow and reach maturity in dynamic conditions with no rotation mechanism or moving parts. SUSPENCE benefits have been confirmed by explanatory morphological and biological tests carried out on an in vitro cell culture. SUSPENCE advantages on competing solutions are: less cell damage, more easy-to-use, increased productivity, better monitoring and control and reduced operation costs. The design of SUSPENCE bioreactor is protected by an international patent application. The target users are research labs and red-biotech firms and; the market size has been estimated in over 6.000 potential customers in EU. Commercialization will start on the Italian market in 20 months from the start of the project, after pre-commercial pilots and industrialization, to expand on the EU market in 36 months and to reach the global market in month 48, after release of larger capacity devices. Forecast revenues are 9 M€/year in the 3rd year of commercialisation. The total financial requirement amounts to about 2.5 M€, with an IRR of 74%. SUSPENCE received thrice the “Seal of Excellence” by European Commission in 2018 (deadline of May, September, November).

Keywords: bioreactor,cell culture,drug tests,in vitro,laboratory equipment,regenerative medicine,tissue engineering
Smart Manufacturing Advanced Research Training for Industry 4.0 (SMART 4.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-06-01
End date: 2024-08-31
Duration (months): 63.0
Total project cost (EUR): 2353920.0
EU funding (EUR): 1176960.0
Participants: 1
Project status: SIGNED

SMART 4.0 is a Fellowship Programme aimed at providing world-class training and research opportunities to 16 post-doctoral fellows in the area of Smart Manufacturing. SMART 4.0, a training, mobility and career development programme, will offer fellowships for incoming mobility of Experienced Researchers. The 24-month training programme will include a project from the fundamental and/or applied research fields of smart manufacturing, a compulsory 3-month secondment at an industry partner (19 placements already pledged), a spring and international summer school, and training in a series of scientific and transferable skills. The training focuses on delivering the next generation Smart Manufacturing leaders with strong “systems-level thinking” interdisciplinary skills to help drive Industry 4.0 forward for Europe. The role of industry is paramount throughout the programme design and implementation due to its critical importance to Europe’s economy. Furthermore, SMART 4.0 is committed to tackle gender inequalities, paying specific attention to attracting and supporting female researchers within smart manufacturing. SMART will publish 2 calls for proposals to attract the very best researchers. Researchers are invited to submit proposals, using an individually-driven, bottom-up approach. The evaluation and selection process will follow the principles of the Charter & Code and will be open, transparent, merit-based and equitable. It will include a remote peer review phase and an interview phase. SMART 4.0 will be implemented by Confirm, a dedicated Smart Manufacturing Research Centre, which brings together 8 Irish universities and a large group of industry partners and international collaborators, constituting an excellent dedicated training environment for the fellows. SMART 4.0 will support increasing Europe’s critical mass in the field of smart manufacturing, as well as support Confirm to host international talent in relevant scientific areas to deliver Industry 4.0.

Keywords: digital manufacturing,industry 4 0,cyber physical systems
Solar Energy Storage PERovskites (SESPer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-13
End date: 2020-11-12
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 3
Project status: CLOSED

Solar energy, attractive source of energy being it free and endless, can be converted into electricity by means of a Concentrating Solar Power (CSP) plant. However, the biggest limit of such technology is the intermittency and the diurnal nature of the solar light. For their future development, CSP plants need to be coupled with storage system. Among the existing thermal storage systems, the ThermoChemical Storage (TCS) is one of the most promising technology and it is based on the exploitation of the reaction heat of a reversible chemical reaction. Just recently, perovskite systems have drawn increasing interest as promising candidates for TCS systems. Perovskites are generally indicated as ABO3, with A and B the two cations of the structure and with O the oxygen. They exhibit a continuous, quasi-linear oxygen release/uptake within a very wide temperature range. Their reduction being endothermic consists in the heat storage step, while the exothermic oxidation releases heat when it is required. The overall objective of the proposal is to study more earth abundant compositions (Ca-, Fe-, Mn- or Co-based) of perovskites for identifying one or more promising candidate storage medium for the design and the realization of a prototype of a multilevel-cascaded TCS system. It aims at solving the no-easy solution problem of the wide temperature range to be covered by a TCS system for CSP plant by using perovskites with different operating temperatures cascaded from the lowest operating temperature to the maximum one. As main result it could bring the TCS systems to a level closer to the market scale. The research project will be developed in collaboration with the IMDEA Energy Institute and the Materials Science and Engineering Department of Northwestern University. This project idea is totally in line with the current strict global energy and environmental politics and also with the Horizon 2020 objectives.

Keywords: solar energy,concentrated solar power plants,thermochemical storage,perovskite
From mind to mind: Investigating the cultural transmission of intergroup bias in children (MINDTOMIND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2024-11-30
Duration (months): 83.0
Total project cost (EUR): 1223054.0
EU funding (EUR): 1223054.0
Participants: 1
Project status: SIGNED

Prejudice and discrimination are pressing social problems. Across Europe, the far right is on the rise, and individuals are often discriminated against on the basis of their race, gender or sexual orientation. The origins of these problematic attitudes and behaviours appear early in development, suggesting that we are passing on our biases to our children. Yet, our knowledge of the complex psychological processes by which these biases are learned remains rudimentary. MINDTOMIND experimentally investigates how children encode, select and transmit biased social information, and so provides a framework for understanding how intergroup attitudes are perpetuated across generations. Until now, artificial boundaries between different areas of psychology have prevented theoretical and empirical progress on this important subject. MINDTOMIND synthesizes cutting-edge research on cognitive development and experimental research on cultural transmission and intergroup psychology in order to provide a comprehensive account of this process. The series of experiments to test the proposed framework will answer three key questions. First, how do children respond to biased information they receive from others? Second, how do children select which social information to consume? Third, how do children transmit biased information to others in their social networks? MINDTOMIND will examine how learning, social motivation and cognitive biases interact to produce prejudice and discrimination. It will demonstrate how negative intergroup attitudes can emerge, become radicalised and spread through children’s social networks. In doing so, it will provide a step-change in our understanding of social cognitive development. In addition to far-reaching theoretical implications, this work will have broad societal implications. It will pave the way towards the development of research-led interventions that can reduce intergroup bias and thus contribute to a fairer and more egalitarian society.

Keywords: social learning,cultural transmission,child development,experimental psychology
Advanced Secure Cloud Encrypted Platform for Internationally Orchestrated Solutions in Healthcare (ASCLEPIOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Cyprus,Finland,Norway,Greece,Sweden,Netherlands,Netherlands,United Kingdom
Call: Toolkit for assessing and reducing cyber risks in hospitals and care centres to protect privacy/data/infrastructures (H2020-SC1-FA-DTS-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-03-31
Duration (months): 40.0
Total project cost (EUR): 4840000.0
EU funding (EUR): 4840000.0
Participants: 12
Project status: CLOSED

The vision of ASCLEPIOS is to maximize and fortify the trust of users on cloud-based healthcare services by developing mechanisms for protecting both corporate and personal sensitive data. The core idea of the project is derived from two observations. The first is based on an extensive analysis of the market on currently available cloud-based health services that aim to preserve users’ privacy without sacrificing functionality. From this study, we observed the following: “Once data is placed on the cloud in an unencrypted form or encrypted with a key that is known to the cloud service provider, data privacy becomes an illusion”. The second observation is based on the consideration of the latest advancements in cryptography. More precisely, one of the saddest but at the same time most fascinating things about cryptography is how little cryptography we actually use. While researchers have developed many theoretical models that could enhance the security level of healthcare services, only a rudimentary set of techniques are currently in use. ASCLEPIOS is addressing these limitations by utilizing several modern cryptographic approaches to build a cloud-based eHealth framework that protects users’ privacy and prevents both internal and external attacks. ASCLEPIOS also offers the ability to users to verify the integrity of their medical devices prior using them while at the same time receiving certain guarantees about the trustworthiness of their cloud service provider. Furthermore, ASCLEPIOS offers a novel solution through which healthcare practitioners and medical researchers are able to calculate statistics on medical data in a privacy-preserving way. Finally, a list of activities with the aim to raise security awareness within the healthcare industry will be organized by project. All these results will be showcased by three real-life near production quality demonstrators provided by ASCLEPIOS healthcare partners, involving three leading European hospitals.

Keywords: e health security,cloud storage security,ehr protection,trusted computing,attribute based encryption,symmetric searchable encryption,security awareness
The on-board railway track & vehicle monitoring system (vmRail)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Detection and rectification of the main accident precursors (broken rails and track buckles) are one of the major issues for all players in railway systems that operate 24/7, at increasing speed, and with a growing number of users. Current inspection tools used for railway monitoring such as laboratory vehicles, self-powered auscultation trains and manually pushed carts require disruption of the railway traffic and are expensive. Additionally, comfort is an essential factor besides maintenance in the competition between railway and other means of transportation. Ride comfort is a complex notion that represents an important criterion when examining the dynamics of railway vehicles and needs to be considered for their modelling and behaviour evaluation. vmRail is the first reliable and cost affordable technology able to combine sensor networks, computer simulation and signal processing to evaluate the state of railways and rolling stocks by comparing track geometry irregularities data and wear & fatigue evolution in real time. Therefore, vmRail simultaneously improves vehicle and track maintenance operations, ride safety, and passenger comfort. With fleets and infrastructures being operated for 30 to 50 years and maintenance accounting for ~50 % of overall cost, the main goal of railway and underground operators is to cost-efficiently increase fleet availability and reliability. Railway and underground operators will benefit of using vmRail by avoiding unnecessary replacements and results in less network disruption due to unplanned/planned maintenance. Moreover, our technology is up to 90% less expensive than current laboratory trains since is based on computing vision, accelerometers and simulations.

Keywords: condition monitoring,preventive maintenance,real time,computer vision,sensor network,safety monitoring,on board system
Constrained Democracy: Citizens’ Responses to Limited Political Choice in the European Union (EUDEMOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1508821.75
EU funding (EUR): 1508821.75
Participants: 1
Project status: CLOSED

National governments operate under the growing constraints of European integration that limit the choices they can offer citizens and the policy instruments they can use. Yet, despite the centrality of political choice to the functioning of electoral democracy, we know very little about the consequences of constrained political choices for citizens’ engagement in democratic processes. Across Europe, an increasing number of citizens are supporting extreme parties or declining to take part in democratic elections. This project offers the first systematic examination of how the range and substance of political choices offered to citizens in the EU shape democratic perceptions and electoral behaviour. Understanding how citizens perceive and react to the growing constraints on domestic politics is crucial to a diagnosis of European democracy and for an evidence-based debate on reform of EU institutions. Building on the Principal Investigator’s award-winning research on electoral democracy and extensive experience of designing and analysing cross-national surveys and experiments, this project is a pioneering study of the consequences of constrained democracy. It uniquely combines a large-N cross-national analysis of citizens’ responses to mainstream party convergence and case studies of the ‘emergency politics’ of the Eurozone crisis with micro-level experimental work. This project aims to transform the study of citizens’ democratic attitudes and behaviour by focusing on the importance of political choice. By developing and testing a theoretical model of heterogeneous citizen responses to the constrained political choice, the project provides insights into why citizens turn against mainstream parties or exit democratic processes altogether. This further allows EUDEMOS to develop proposals for how institutions can be designed to facilitate citizens’ participation in and satisfaction with democratic processes in a multi-level European Union.

Keywords: democracy,european union,elections,public opinion,political parties,european integration,political choice
Discovery of novel orphan riboswitch ligands (RiboDisc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2022-09-30
Duration (months): 78.0
Total project cost (EUR): 1918600.0
EU funding (EUR): 1918600.0
Participants: 1
Project status: CLOSED

Riboswitches are mRNA-based gene-regulatory elements triggered by direct interactions with small molecular ligands. They are exciting targets for novel antibiotic strategies. Many putative riboswitches have been identified using bioinformatics. However, ligand identification is getting more complicated since many motifs are not expected to be involved in simple feedback regulation mechanisms. For such “classical” riboswitches ligands have been assigned in the past based on testing metabolites selected by educated guesses guided by the associated gene contexts. We are convinced that this approach limits the identification of riboswitches that play regulatory roles in more complex bacterial processes such as virulence, detoxification, communication, and life style adaptations. Within this project, new riboswitch classes will be identified and characterized, paving the way for the development of antibiotics with novel modes of action. We will establish a systematic, robust and unbiased approach for identifying intracellular RNA ligands by fishing small molecules from lysates as well as screening fractionated cellular extracts. The methodology shows great potential for assigning novel riboswitch classes since in preliminary experiments we have successfully isolated a small molecular activity that specifically triggers the ykkC orphan riboswitch motif. A range of analytical and preparative methods will be applied in order to identify the nature of this and further activities. By synthesizing ligands and derivatives thereof we will scout the antibiotic potential of novel riboswitch ligands. The proposed research is highly relevant for one of the major biomedical challenges of the coming decades: Since riboswitches are effective antibacterial targets, the identification of novel riboswitch / ligand interactions has immediate implications for establishing future antibiotic strategies necessary to keep in check the progressing problem of bacterial drug resistance.

Keywords: ligand interactions,riboswitches,control of gene expression
CLIC - Circular models Leveraging Investments in Cultural heritage adaptive reuse (CLIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Cultural heritage
Action type: Research and Innovation actions
Countries involved: Austria,Ireland,Italy,Germany,Italy,Italy,Italy,Belgium,Poland,Slovenia,Sweden,Croatia,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative financing, business and governance models for adaptive re-use of cultural heritage (H2020-SC5-2017-OneStageB, 2017)
Start date: 2017-12-01
End date: 2021-08-31
Duration (months): 45.0
Total project cost (EUR): 4957033.0
EU funding (EUR): 4957033.0
Participants: 17
Project status: CLOSED

The characteristics of cultural heritage and landscape pose significant challenges for its governance. Long since cultural heritage is considered as a resource for local development strategies. But there are some contradictions. The sites recognized as cultural heritage are increasing; the costs for functional reuse are growing, while public resources available are becoming scarcer, and private actors are increasingly focused on the short time for payback. The consequence is that there is a growing risk that the decay of heritage will increase year by year because of lack of financial support. Cultural heritage is a non-renewable capital and it is linked to the economy because economics refers to the management of scarce and non-renewable resources; for these reasons, heritage conservation is also an economic choice. The CLIC project addresses significant challenges of cultural heritage and landscape adaptive reuse. It progresses the agenda on heritage-led local sustainable development by developing flexible, transparent, integrated and inclusive tools to manage the change of cultural landscape, which are required to leverage the potential of cultural heritage for Europe. The investment gap in cultural heritage and landscape regeneration will be addressed by CLIC through careful evaluation of all costs, of "complex values" and impacts of adaptive reuse, selecting function(s) not only linked to tourism attractiveness, but also for the well-being improvement, providing critical evidence of wealth, jobs, social, cultural, environmental and economic returns on the investment. The overarching goal of the CLIC trans-disciplinary research project is to identify evaluation tools to test, implement, validate and share innovative "circular" financing, business and governance models for systemic adaptive reuse of cultural heritage and landscape, demonstrating the economic, social, environmental convenience, in terms of long lasting economic, cultural and environmental wealth.

Keywords: circular economy,cultural heritage,heritage conservation,circular governance models,digital social innovation,urban development,adaptive reuse,systemic innovation,knowledge management