Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ANTAGONISTS OF PROTEIN-PROTEIN INTERACTIONS (APPI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-03-15
End date: 2011-03-14
Duration (months): 36.0
Total project cost (EUR): 318727.84
EU funding (EUR): 318727.84
Participants: 1
Project status: CLOSED

Dysregulation of cytokine gene expression and cytokine regulated gene expression is the root cause of many diseases including viral and bacterial infections and chronic inflammation. In recent years, a variety of molecular biology and biochemistry research tools enabled the study of direct protein-protein interactions among various cytokine receptors and transcription factors which establish, maintain, and coordinate transcriptional regulation of cytokine genes. Currently, novel technologies and emerging statistical tools have enabled the use of translational genomics which involves the study of large sets of genes and proteins, with the goal of understanding systems, not simply components. An excellent complement to state of the art will be to apply translational genomic tools and molecular biology techniques to establish novel experimental models leading to a functional understanding of disease and the development of systems-based medical solutions. The aim of this proposal is to enable the researcher to acquire substantiated state of knowledge in translational genetics in the partner organisation "Translational Genomics Research Institute" (TGen) which provides the data and tools necessary to identify the genes that play a role in hereditable diseases and understand the genetic changes contributing to disease progression. The researcher will assemble its own genomic research platform in order to translate genetic information of infection and inflammation diseases at TGen. She will build up a new independent platform in The Helmholtz Centre for Infection Research (HZI) which utilizes translational genetics research to establish infection and inflammation relevant cell-based models and uses chemical biology and competent compound collections in HZI to identify and create new bioactive small molecules for targeting disease relevant protein-protein interactions. This forward-looking project will significantly contribute to HZI competitiveness.

Keywords: translational genomics,chemical biology,protein-protein interaction,infection,inflammation
Dissecting dynamic monoaminergic nervous system in C. elegans with genetically-encoded neuron activator protein channelrhodopsin-2. (YTANIZAWA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 178874.06
EU funding (EUR): 178874.06
Participants: 1
Project status: CLOSED

Biogenic monoamines are relevant to influential psychological diseases and brain plasicity. Knowledge obtained so far is however not enough for both of scientific and medical purposes. One obstacle against proceeding is the difficulty to find novel genes in genetically-inaccessible system like human brain. Another problem is the complexity of brain making it difficult to link cellular phenomena to behavior, which is necessary to understand brain. To solve these problems, a genetically-accessible model organism C. elegans was introduced. With only 302 neurons, nervous system of C. elegans still has many properties common to the higher animal’s brain, including usage of monoamines and their roles in neural plasticity. Studies so far in C. elegans have provided much information by using mutants, exogenous amine application and neuron ablation. However, these methods have not considered dynamic property of aminergic system. Here, the applicant uses the genetically-encoded light-gated cation channel channelrhodopsin-2 (ChR2). Because the body of C. elegans is transparent, by expressing and light-activating ChR2 specifically in aminergic neurons, one can examine the amine effectss on behavior with precise time resolution. The automated behavior quantification system makes it possible to identify any subtle behavioral changes caused by aminergic activation. The applicant will also examine the amine effects in cellular level, by live-imaging of downstream neuron activity with sensor protein cameleon. After identifying the amine effects, the applicant will start to dissect aminergic system with powerful genetics of C. elegans, which will provide a good starting point for further studies in future. This project for the first time allows us to examine the dynamic aspects of genetically-dissectable aminergic system, so it will contribute much to understanding aminergic system and also to European excellence in this promising and competitive field of C. elegans neurobiology.

Keywords: behavioural biology,genetics,neurobiology,behavioral plascitity,neural plasticity,c. elegans,model organism,nervous system,dopamine,serotonin,live-imaging,actuator,in vivo
The Socio-Technical Evolution of Intellectual Property Online: Creating Counterfeit Culture (STEVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-11-01
End date: 2011-10-31
Duration (months): 24.0
Total project cost (EUR): 215690.72
EU funding (EUR): 215690.72
Participants: 1
Project status: CLOSED

Recent years have seen a major shift in the nature of counterfeiting for goods such as music, video, computer games and software. Growth broadband and the increased demand for content have contributed to the exponential growth in the illegal copying and exchange. A new relationship between intellectual property (IP) owners and consumers has developed where tensions between control and access is being negotiated and, at times, resisted. Further, the piracy of digital products has become normalised and accepted across the complete demographic range of users – a counterfeiting culture. Working with consumers, industry and policy stakeholders, the research proposed during the Fellowship has the objectives to explore: The role, added-value and control of user-generated IP; The normalisation of activities associated with IP crime; Negotiating IP owner rights and user privileges. Using Dr Rutter’s previous research as a theoretical foundation, the research will demonstrate the weaknesses in assumptions previously made about the consumption of counterfeit goods, namely that: it can be simply linked to user income; maximisation of utility can satisfactorily explain user behaviour; it is a practice limited to young consumers; and, that unlicensed use of IP is always detrimental to competitiveness. In order to do this, an innovative combination of research methods will be employed to explore both demand and supply side activities in the area and the consequences for innovation.

Keywords: socio-economic research,counterfeiting,piracy,online interaction,media consumption
Theory Applied to Real Embedded Systems (TARES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 181490.02
EU funding (EUR): 181490.02
Participants: 1
Project status: CLOSED

Our project, entitled Theory Applied to Real Embedded Systems (TARES), aims to bridge a gap between theory and practise for the design of Embedded Systems. We are going to apply recent advanced theories and tools developed for timed systems to the design of existing and commercialised software products which are based on the L4 micro-kernel technology. A micro-kernel is an operating system that provides a restricted set of services; the micro-kernel L4 provides threads, basic scheduling, inter-process communications and virtual memory. The project will be carried out over 3 years by Franck Cassez at NICTA/Sydney (http://nicta.com.au/), Australia, in the Embedded Real-Time Operating Systems (ERTOS) and Formals Methods (FM) groups.

Keywords: embedded systems,verification,control,technological sciences
Doped Magnetic ZnO p-n Junction Heterostructures for Nano-Spintronic Devices (MAJIC-SPIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-07-01
End date: 2010-06-30
Duration (months): 24.0
Total project cost (EUR): 168823.92
EU funding (EUR): 168823.92
Participants: 1
Project status: CLOSED

Semiconductor materials form the basis of modern electronics, communication, data storage and computing technologies. One of today’s major challenges for the development of future technologies is the realization of devices that control not only the electron charge, as in present electronics, but also its spin, setting the basis for future spintronics. Spintronics represents the concept of the synergetic and multifunctional use of charge and spin dynamics of electrons, aiming to go beyond the traditional dichotomy of semiconductor electronics and magnetic storage technology. The most direct method to induce spin-polarized electrons into a semiconductor is by introducing appropriate transition metal dopants producing a dilute magnetic semiconductor (DMS). The seamless integration of future spintronic architectures into nanodevices would require the fabrication 1-D DMS nanostructures in well defined architectures. In this project we propose to use a simple low-cost, low-temperature electrodeposition process to not only synthesise and characterise ZnO based bipolar DMS nanowire heterostructures but, even more importantly, fabricate an array of p-n and n-p-n junctions which could lead to novel nano-spintronic devices within ordered pre-defined nano-architectures. We will study the structural and functional properties of these heterostructures, which could have applications such as spin polarised LED and spin polarised bipolar junction transistor. By fully exploring the parameters controlling the growth and functionality of these materials we will try to gain a holistic understanding of the processing/structure/property relationships for this system. The ultimate goal of this project is to be able to design and fabricate specific nanowire heterostructures with tuneable magnetic and electrical properties which could lead to practical spintronic applications. Moreover this approach is inherently clean and scalable and easily integrated within current industrial practice.

Keywords: electrochemistry,nanotechnology,spintronics,nanowire arrays,materials chemistry
Interaction dynamics of micro-plasmas (ID:Μ-PLASMAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-01
End date: 2010-03-31
Duration (months): 24.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

The unique nature of ionised matter, specifically the exotic properties of non-equilibrium low-temperature plasmas, has continuously generated increasing attraction of plasma science and technology. One of the most fascinating areas, for both fundamental science and technological applications, is the emerging field of atmospheric pressure plasmas. The scientific fundamentals of plasmas in this new parameter regime are so far only rudimentary understood and need to be discovered. It is timely that European scientists foster a leading role in this area. The key issue in understanding fundamental processes towards their intelligent use for tailoring plasma properties is insight into power coupling, plasma sustainment and energy transport mechanisms. There has been some recent progress in understanding single micro-plasma devices, but the vital interaction of multiple micro-plasma devices is far more complex. This project focuses on investigating the elementary mechanisms of the interaction of multiple micro-plasma devices, of particular importance in 1-dimensional and 2- dimensional arrays. Diagnostics of micro-plasmas is extremely challenging due to their very small structures, in the order of microns, and the collision dominated high pressure environment requiring exceptionally high temporal resolution down to pico-seconds. Modelling and numerical simulations are mainly restricted due to the lack of available data, especially for surface processes which are crucial at these small dimensions. The most promising approach is exploiting the synergy of combining various newly available modern diagnostic techniques with modelling and simulation of measurable quantities. The lack of available data for the model can be overcome by using experimentally measured quantities as fixed parameters in the model. Essential diagnostics are laser spectroscopic techniques and optical emission spectroscopy - both with the required pico-second resolution.

Keywords: natural sciences,physical sciences,technological sciences,plasma physics,low-temperature plasmas,technological plasmas,atmospheric pressure plasmas,micro-plasmas,plasma diagnostics
Quantifying Objectivity in the Natural and Social Sciences (OBJECTIVE SCIENCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 161792.99
EU funding (EUR): 161792.99
Participants: 1
Project status: CLOSED

Every year, over 1.4 million scientific articles are published worldwide. How many of them are objective and unbiased descriptions of real phenomena? Increasing evidence suggests that malpractice and publication bias are seriously affecting modern research. Their effects, combined with biased science communication, are potentially distorting scientific knowledge to an unprecedented degree. Research agendas and political agendas risk being misdirected, and human and financial resources risk being wasted on scientific questions that are based on false assumptions. The nature and gravity of this phenomenon, as well as its consequences, are only starting to be investigated. The project aims at assessing the level of bias in the natural and social sciences by focusing on three fundamental phases in the production of scientific knowledge: data collection, publication, and popularization of results. With interviews and a survey sent to thousands of European researchers in all scientific fields (astronomy, biology, chemistry, earth science, physics, sociology, economics, political science), the project will investigate research malpractice (e.g. data falsification, fabrication, plagiarism) in Europe. With advanced statistical techniques and a very broad data set, it will quantify publication bias in all scientific disciplines, producing the first comparative and interdisciplinary study of this phenomenon. By analysing discourse and narrative in popular science articles and in editorials of scientific journals, it will investigate public’s attitude towards research integrity and bias. The project will contribute to maintaining the reputation of excellence of European research, and it will be of great interest to decision makers and to scientists in all disciplines. In addition, it will allow the fellow to train in many techniques of social research, and to resume a scientific career addressing a largely unexplored field of study.

Keywords: social sciences,research methodology,sociology of labour,research integrity,publication bias,scientific misconduct,sociology of science
Nutritional ecology and seasonal colour polymorphism in a butterfly (POLYCOLOR NUTRITION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-06-08
End date: 2011-06-07
Duration (months): 24.0
Total project cost (EUR): 172167.92
EU funding (EUR): 172167.92
Participants: 1
Project status: CLOSED

Large colour ornaments such as bright plumage in birds or vivid wing coloration in butterflies are some of the most intriguing phenomena in the natural kingdom. However, the selective pressures and constraints involved in the evolution of these traits are in most cases poorly understood. Here we posit that evaluating the underlying nutritional demands of large colour patterns promises to provide novel insights in to the evolution of colour traits. Colour patterns can represent surprisingly large pools of specific nutrients. For example, male Cabbage White butterflies (Pieris rapae) invest as much as 15% of their total adult nitrogen in wing pigmentation alone. However, despite the substantial resource draw that many colour patterns impose on their bearers and the potential importance of these resource demands to other morphological and life history traits, the nutrient dynamics underlying production of colour traits have rarely been considered in studies of their evolution. We will evaluate the importance of nutrient ecology in the evolution of the distinct seasonal colour forms of the European Map Butterfly, Araschnia levana. This butterfly exhibits an orange, ommochrome-dominated spring form and a black-and-white, melanin-dominated summer form. These two colour forms differ substantially in the nutrient demands they impose, with the former requiring large amounts of tryptophan, whereas the latter requires large amounts of phenylalanine and/or tyrosine. In order to better understand the evolution of this colour polymorphism, we will evaluate seasonal differences in nutrient availability, acquisition and allocation. We will also explore the role of hormonal control in mediating nutrient-based life history tradeoffs associated with these two distinct colour phenotypes. We expect that synthesis of results from the proposed studies will allow us to more thoroughly understand the evolution of this colour polymorphism, and colour traits more generally.

Keywords: animal ecology,entomology,functional biology,evolutionary biology,nutritional sciences,animal physiology,evolution of coloration
Integrated Laser Sensor for Exhaled Anaesthetic Agent Monitoring (INTELSENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 178874.06
EU funding (EUR): 178874.06
Participants: 1
Project status: CLOSED

The application of a novel ultra-sensitive photoacoustic gas sensor is proposed to allow for online monitoring of an intravenously administered anaesthetic agent, which is exhaled at trace levels with the patient’s breath during surgery. We respond to a real and acute need for clinical online monitoring of anaesthetic concentrations in the patient’s blood stream during surgery. In the drafting of this proposal, the Applicant, himself from a physical sciences background, has extensively consulted with Prof. T. Absalom and Dr. D Wheeler, Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, UK to define the clinical problem at the core of this application. The project focuses on the monitoring of propofol, one of the most widely used intravenous anaesthetics in general anaesthesia. Currently the effectiveness of propofol induced anaesthesia is only assessed symptomatically, based on highly subjective and unsophisticated scoring. A viable online capability to monitor exhaled trace levels of propofol in patients does not currently exist but would dramatically improve the level of control over its administration. It would both improve the quality of anaesthetic management by tailoring dosage to the individuals’ needs, reduce clinical recovery times and patient aftercare with associated cost benefits. The project is based on a unique interdisciplinary ensemble of physicists, chemical engineers, medical professionals and potential commercial manufacturers focusing on a high impact engineering challenge. The Applicant has an excellent academic background. He has already gained international recognition in terms of invited conference contributions. He has been one of the key players to develop the proposed sensor technology. The proposed high impact project in a multidisciplinary environment at the University of Cambridge, UK, would fully qualify the Applicant for an independent research post at an internationally recognised research institution.

Keywords: chemical engineering,applied optics,photoacoustic spectrocopy,medical physics