Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How do pathogens exploit the symplast to promote disease? (HOPESEE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

It is well established that pathogens invade plant cells to establish an infection. Part of a biotrophic pathogen’s infection strategy is to secrete effectors into host cells in order to manipulate host processes to the pathogen’s benefit. It has been observed that some effectors can move from cell-to-cell in the host and this suggests that a pathogen can invade and exploit cells surrounding the immediate infection site. To further support this hypothesis, my host lab observed that PAMP-induced plasmodesmata (PD) closure is suppressed in some virulent infections, suggesting pathogens attempt to keep intercellular connections open; some pathogens must maintain intercellular symplastic connectivity by counteracting PAMP-induced PD closure to promote disease. This proposes the question: why does a pathogen want PD open? We hypothesise that open PD allow pathogen effectors to move into non-infected cells where they targeting host processes to promote infection and allow pathogen access host resources such as sugars. In this study, I will use the Hyaloperonospora arabidopsidis– Arabidopsis interaction to identify cell-to-cell mobile effectors and their host targets. I will identify global changes of host gene regulation that are associated with cell-to-cell mobile effectors and examine the effect of cell-to-cell mobile effectors on sucrose transport around an infection site. The results will give insight into how pathogens exploit the symplast and non-infected cells to promote infection, characterising a poorly considered element of plant-pathogen interactions.

Keywords: plant pathogen interaction,plasmodesmata,effector,symplast,inter cellular communitcation
Enzyme-powered DNA nanorobotic devices (DNA-bots)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

WHY: Enzyme-powered nanorobotic devices are able to self-propel thanks to the conversion of a substrate into products, holding a great potential for biomedical applications. A step forward in the field would be the precise control and design over the structure and enzyme spatial configuration, as well as the integration of complex functions. WHAT: DNA-bots is an interdisciplinary approach in which enzyme-propulsion and DNA nanotechnology will be merged to develop a new class of biocompatible and biodegradable nanorobotic devices able to self-propel, sense and actuate in front of specific stimuli. To achieve this goal, I will undertake a high risk/high gain research approach at the forefront of nanotechnology. The leading idea is to design and fabricate DNA nanostructures which will be site-specifically functionalized with enzymes to generate self-propulsion. The enzyme-powered DNA nanorobots will be further engineered by integrating DNA nanoswitches able to sense and perform loading and release of cargoes upon specific stimuli. HOW: The challenge met by this Project is to provide a groundbreaking contribution to DNA nanotechnology and nanorobotics. To achieve these objectives, I will be trained at the Host group led by Prof. Francesco Ricci (University of Rome Tor Vergata, Italy), which is a young and dynamic team at the vanguard of the use of DNA nanotechnology for sensing and drug-delivery applications. The Fellowship will proceed through a well-defined set of research and training tasks, organized into four work packages. Thanks to this MSCA Fellowship, I will continue expanding my scientific knowledge and acquiring cutting-edge skills (in synthetic biology, DNA nanotechnology, and nanorobotics), which will significantly impact my career as a researcher and help me to strenghten my position as an independent and mature researcher.

Keywords: dna nanotechnology,enzyme powered nanorobots,synthetic biology
Implementing Special Nanomaterials in Ultra-performance Mobile Radomes (OxfordNano)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-08-01
End date: 2019-01-31
Duration (months): 18.0
Total project cost (EUR): 149811.25
EU funding (EUR): 149811.0
Participants: 1
Project status: CLOSED

OxfordNano aims to enhance the EU manufacturing capability in aerospace composite structures using special nanomaterials (NMs) technology derived from ERC research. The target application for this capability is ultra-performance radomes for airborne sensors systems and a growing opportunity to deliver digital services to users on the move e.g. passengers in civil aircraft and trains. Mobile radomes for the aviation industries need to be strong in structure and impact, lightweight and easily formed to aerodynamic shapes, and be resistant to erosion and lightning. Above all the radome must be transparent i.e. have the minimum insertion losses for that operational frequency range. In the last 40 years, a range of insulating materials such as ceramics and resin composites have been used to optimise properties such as durability against environment yet possessing maximum and/or tunable radio frequency transparencies. However, in advanced high-mobility applications utilisation of modern lightweight nanocomposites as structural materials for radomes with superior toughness, thermal properties and other functionalities are essential. OxfordNano’s European Industry project partners in the areas of advanced materials, composite manufacturing and radome design will apply speciality NMs to solve the formidable technical problems in engineering multifunctional composites for radomes, where conventional materials and engineering approaches are reaching the limit of their impact. There has been much recent progress in understanding NMs formation and scaled-up production techniques from laboratory scale to industrial scale manufacturing. Many technical barriers have been identified in this area of research. At present there is no known commercial technology using h-BN multi-wall nanotubes (BNNTs) at scale. Specially tailored h-BN NMs including h-BN nanotubes from Oxford¹s ERC programmes will underpin the development of ultra-performance mobile radomes.

Keywords: nanomaterials,radomes,manufacturing,composite materials,lightweight,mobile,wireless transmission
Robust SPEAKER DIariazation systems using Bayesian inferenCE and deep learning methods (SPEAKER DICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 142720.8
EU funding (EUR): 142720.8
Participants: 1
Project status: CLOSED

The proposed project deals with Speaker Diarization (SD) which is commonly defined as the task of answering the question “who spoke when?” in a speech recording. The first objective of the proposal is to optimize the Bayesian approach to SD, which has shown to be promising for the tasks. For Variational Bayes (VB) inference, that is very sensitive to initialization, we will develop new fast ways of obtaining a good starting point. We will also explore alternative inference methods, such as collapsed VB or collapsed Gibbs Sampling, and investigate into alternative priors similar to those introduced for Bayesian speaker recognition models. The second part of the proposal is motivated by the huge performance gains that, in recent years, have been brought to other recognition tasks by Deep Neural Networks (DNNs). In the context of SD, DNNs have been used in the computation of i-vectors, but their potential was never explored for other stages of SD. We will study ways of integrating DNNs in the different stages of SD systems. The objectives of the proposal will be achieved by theoretical work, implementation, and careful testing on real speech data. The outcomes of the project are intended not only for scientific publications, but eagerly awaited by European speech data mining industry (for example Czech Phonexia or Spanish Agnitio). The project is proposed by an excellent female researcher, Dr. Mireia Diez, having finished her thesis in the GTTS group of University of the Basque Country, one of the most important European labs dealing with speaker recognition and diarization. The proposed host is the Speech@FIT group of Brno University of Technology, with a 20-year track of top speech data mining research. The proposed research training and combination of skills of Dr. Diez and the host institution have chances to advance the state-of-the-art in speaker diarization, provide the applicant with improved career opportunities and benefit European industry.

Keywords: speaker diarization,speaker recognition,variational bayes inference,deep neural networks,speech data mining
Development of a platform for a new model of interaction between geneticists and patients with Mendelian diseases. (PLATGENE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Italy
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our project aims to develop at European level a new business model intended to end the expensive and stressful diagnostic odyssey experienced by patients affected with a Mendelian disease, needing genetic testing to confirm or clarify the diagnosis. We intend to achieve this goal through dissemination and marketing at European level of the platform “Genica.eu” which we tested in the Italian market. Such platform allows meeting between patients looking for a reference center, expert geneticists able to interpret genetic data, and BMR Genomics as service providing technology and expertise to manage the overall project. Genetic testing has been facing an exponential growth in the last years, due to the rapid evolution of Next generation sequencing technologies for DNA analysis, the reduction of sequencing costs and the increase of the overall number of genes linked to Mendelian diseases. However, the current genetic testing process is highly fragmented and there is a lack of harmonization in the genetic services offer between European countries. Our project wants to enter the genetic testing market and aims to satisfy the growing need to organize and enhance the affordability of genetic services, as well as to use and manage genetic data for diagnosis of rare diseases. The feasibility study under Phase 1 has the purpose to develop the business plan in: European market analysis (target customers, user needs, competitors, SWOT analysis, stakeholders); organizational structure and operational network, regulation and know-how management; analysis of costs and profitability. The project addresses some Europe's challenges: the need to facilitate improvements in diagnosis and delivery of high- quality, accessible and cost-effective healthcare for all patients with medical conditions requiring rare expertises and the need to enable and facilitate the exchange of expertises among European countries and to harmonize the genetic testing offer and affordability.

Keywords: geneticists,patients,mendelian diseases,matching platform,expertise shearing,new interaction system,new business model,cross border genetic counseling
Inclusive DIALOGUES towards an operational concept of energy citizenship to support the Energy Union (DIALOGUES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Germany,Austria,Switzerland,Norway,Türkiye,Bulgaria,Greece,Canada,Portugal
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 3194843.75
EU funding (EUR): 2997156.25
Participants: 13
Project status: SIGNED

DIALOGUES will support the Energy Union with operational research on energy citizenship that enables citizens to take a central role in the energy transition. To reach this objective the project will operationalise, contextualize, measure, and support the framework environments, policies and institutions that allow deep, inclusive energy citizenship to emerge. The key focus of DIALOGUES is on co-creating energy citizenship innovations that include the perspectives of groups currently on the margins of the energy transition such as, women, low-income households, energy poor, and ethnic minorities. DIALOGUES central methodological pillar is grounded in tested inter- and transdisciplinary techniques, with a spotlight on open innovation and co-design of the research process through novel Citizen Action Labs in 8 countries. For the policy and research communities, DIALOGUES will move the idea of energy citizenship forward to an operational concept that offers actionable policy insights, applied research tools and a unifying theory for citizen-oriented energy research. The project will develop tools to measure the degree, and map the modes, of expressing energy citizenship, related KPIs, a policy decision tool, and a Knowledge Platform linking all project data and results. Policymakers & stakeholders from the DIALOGUES levels of analysis: community, local/regional, and national/supranational, will be included through co-creative workshops and policy briefs. A Policy Advisory Group of leading energy experts, research centres and institutions, local governments, city networks and NGOs will frame the DIALOGUES research process to ensure maximum impact on all geo-political levels. The project will foster deep, multilateral exchanges with the 72 supporting organisations, in 13 nations, including Canada whose partnership allows DIALOGUES to extend the dissemination network significantly and improve scientific robustness through sharing best-practices and comparative analysis.

Keywords: energy citizenship,lifestyles,co creation,citizen action labs
Development and Commercialisation of the ‘Next Generation’ patient-centric wearable Tube Feeding System (Mobility)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Ireland,Ireland,Poland
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 4034147.59
EU funding (EUR): 2854935.85
Participants: 5
Project status: SIGNED

The consortium's mission is to radically improve the lives of people dependant on the use of tube (enteral) feeding. This is an under-served segment that experiences low patient satisfaction and high patient distress. Patients and clinicians alike agree that enteral feed patients’ needs are not being adequately met by current options. Over 1,000,000+ people in Europe and US are dependent on tube feeding every day, expected to increase by 8% over the next 3 years. Over 300 conditions require daily tube feeding, such as Cancer, MS, Cystic Fibrosis and Diabetes. Mobility+ will transform the tube (enteral) feeding market by introducing a game-changing user-centric feeding system. Users in both home settings and hospitals demand simplicity, ability to feed discreetly when on the go, enhanced functionality and are looking for the tube feeding to be as normalised an experience as possible. Mobility+ is a complete solution that ensures the wellbeing of tube feeding users and provides new functionalities. It will replace existing cumbersome, complicated, expensive solutions utilising electricity driven pumps and it will disrupt existing business models of how enteral feed is sold and distributed. This consortium seeks funding through the H2020 Fast Track to Innovation Pilot Scheme H2020-EIC-FTI-2018-2020 programme to accelerate the commercialisation our innovative technology (currently at level TRL 6). We aim to transform and significantly improve care for patients requiring tube feeding. We have assembled a business focused consortium to achieve commercialisation in target markets by month 30 from project start.

Keywords: mobile,enteral feeding,medical nutrition,integrated healthcare
Melt Transportation in the Earth's Crust: An Experimental and Numerical Evaluation of Natural Materials (MeltTransport)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The Earth’s continental crust is compositionally layered, hosts natural resources and energy sources sustaining our civilization and represents an important record of the Earth through geological time. A fundamental control on the structure and heterogeneity of the Earth’s continental crust is the formation, migration and emplacement of fully and/or partially molten rocks. The upper crust is richer in silica than in the lower crust and these rocks is where many of the elements that are essential for life are concentrated. The required chemical differentiation and measured geochemical signatures suggests they must be sourced from melting of lower crustal and mantle environments. This requires melt transfer through the lower and middle crust. However, compared to the generation of melts, the transport and accumulation of such melts is still poorly documented and understood. The movement of melts in the crust is responsible for mineral resource formation, hazards (e.g. earthquakes, volcanic eruptions) and is a fundamental enabler of plate tectonics – a feature that is unique to Earth. The ‘MeltTransport’ project will interrogate natural examples of melt migration and accumulation using an innovative combination of multidisciplinary techniques and state-of-the-art analytical facilities, including a one-of-a-kind experimental apparatus, to provide new insights into this fundamental process. This project will investigate melting processes through three main methods: (1) quantitative microstructural and chemical characterisation, (2) physical experimentation and (3) numerical modelling. This combination of methods will permit visualisation and quantification of (i) how the interaction between melts and the host rock (melt–rock) varies with different pressure/temperature/deformation scenarios, (ii) the formation of microstructures and features during melt extraction/migration/emplacement, and (iii) geochemical characteristics associated with particular microstructures.

Keywords: melting processes,crustal differentiation,experimental geology,numerical modelling,high grade metamorphism
New approach to decentralized production of electricity, water supply and Internet connection, in full autonomy and off-grid (CUBE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The reliable access to clean water, electricity and to the Internet altogether is a prerequisite to social and economic development. There is no perspective of growth without these resources. And yet, this is the case for two billion people today, who live in isolated areas, regions damaged by war or a natural disaster or suffering from poor infrastructure. Despite a strong commitment, the actions of public organizations and NGOs remain limited: the access to water and electricity off-grid remains complex and very costly. It takes at least a full year for areas in need to get the proper infrastructure. In this context, the company ZEST, specialized in the production of off-grid energy fluids (power, water, connectivity) has developed a disruptive concept named CUBE. CUBE refers to an autonomous and plug-and-play solar-powered system, able to create supply points in electricity, clean water and internet in IoT cubes of 585 x 585 x 585 mm. The cubes combine inverting technologies to produce and store electricity (230V), filtering systems (reverse osmosis and UV lamp) to supply clean water and several connection types (4G/ 3G, edge and satellite connection) to link the cubes to an IoT platform, where big data are processed. Real-time analysis will deliver smart guidance and tailored training for low energy consumption by the users. With a lifespan of about a decade, the cubes have the potential to make any building, housing or operation site (e.g., construction sites) autonomous . They also can create circular economy wherever in use. It is both a transformative technology and a disruptive societal innovation. The Phase 1 project will validate: - the artificial intelligence (AI) components in the cubes - their low-energy consumption approach (reduction of 40% the energy losses observed today) - the targeted business model: product-oriented in developed countries and focusing on knowledge transfer and smart training in developing countries.

Keywords: off grid,power,water,connectivity supply points,autonomous building,creation of economic activity,smart training,knowledge transfer,remote maintenance,education,sustainable energy consumption