Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
WATERSIGN: Smart Water Monitoring & Leakage Detection (WATERSIGN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-06-01
End date: 2022-02-28
Duration (months): 33.0
Total project cost (EUR): 3013616.0
EU funding (EUR): 2109531.2
Participants: 2
Project status: CLOSED

To enable a more efficient use of water and limit wasteful usage, real time monitoring and alerts in case of burst, blockage or leakage is needed to empower consumers to take corrective action as quickly as possible. Tavlit's Watersign System’s disruptive patented technology reduces water wastage and maximizes the efficient use of water, thereby preserving scarce resources, by enabling real time monitoring of water supply lines and irrigation systems. The system is simple and economical, making it an ideal solution for water management. Using the water itself as the medium to transfer the data, the system detects leakages, bursts, blockages, water theft and unauthorized connections, identifying the specific point/location of the disturbance, and alerts the user immediately so that corrective action can be taken. The system analyses water consumption patterns and sends alerts in the case of irregular behaviour, as well as immediately sending an alert when non-potable water enters a potable water system. The system is comprised of just one sensor located at the inlet of the water system being monitored, while each individual water outlet is equipped with a Watersign-marker, a mechanical device operated by the water flow, creating small flow/pressure fluctuations in the water, generating a unique signature at every outlet, identifying each user by small fluctuations in the water flow/ pressure. The water itself is used as the medium to transmit information from all markers simultaneously to the sensor located at the inlet of the system. A smart algorithm separates between signals and identifies each user, sending an immediate alert in case of irregular behaviour. The project’s objective is to bring the Watersign System to full commercialisation using Tavlit’s global market presence and reputation. Throughout the project, pilot sites will be operational, including agricultural, landscape & turf and golf course sites, as well as rural village and water utility pilots.

Keywords: water conservation,water monitoring,sensors,flow fluctuation,leak detection
The role of Ubiquitin System on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells (IntestineUb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-11-01
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The epithelium of small intestine has a higher self-renewal rate than any other mammalian tissues. This is fuelled by the intestinal stem cells which reside near the bottom of crypt. Tight regulation of the adult stem cell number is required to sustain an adequately sized population for optimal tissue homeostasis. Mis-regulation of homeostasis results in either hyperplasia or loss of stem cells. Although transcriptional regulation of stem cell homeostasis regarding multipotency and differentiation has been extensively studied, only little is known about post-translational modifications. A key mechanism of post-translational modification is ubiquitination by the ubiquitin system (US). The in vitro primary intestinal organoid culture system recapitulates in vivo epithelium organization, is amenable to essentially all experimental technologies that have been developed for cell lines, and therefore serves as a novel, robust and powerful model system. Taking advantage of the intestinal organoids, this project is aimed to investigate the role of US on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells by: 1. Screening of US required for stem cell number regulation by CRISPR/Cas9 technology; 2. Characterization of the expression pattern and sub-cellular localization of candidate US; 3. Examining the effect of candidate US in signalling pathways involved in the homeostatic control by reporter assay and target gene expression; 4. Identifying target proteins of candidate US using surface proteome analysis, IP-mass, BioID or in vitro ubiquitination of arrayed proteins; 5. Performing biochemical and cell biological analysis of candidate US with its identified target proteins and signalling pathway components in vitro; 6. Generation of conditional knockout mouse models to elucidate the function of candidate US in vivo; 7. Conducting a small molecule screening for inhibitors that attenuate hyperplasia phenotype caused by E3 ligases mutation.

Keywords: intestine,stem cells,ubiquitination,signalling
MASSTWIN – Spreading excellence and widening participation in support of mass spectrometry and related techniques in Health, the Environment, and Food Analysis (MASSTWIN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Germany,Spain,Belgium,Slovenia,France,France
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 980617.18
EU funding (EUR): 980617.18
Participants: 7
Project status: CLOSED

The Department of Environmental Sciences at Jožef Stefan Institute has invested in new state-of-the-the-art mass spectrometry instrumentation and related laboratory infrastructure, an important and essential technique in modern science, but must now bolster its knowledge capacity and raise its research profile through taking practical steps in training and knowledge transfer and networking activities. The project has been designed to further stimulate cooperation and develop long-term strategic partnerships with five research institutes of excellence from five different European countries by establishing a community of practice in advanced mass spectrometric and related techniques applied to three trans-disciplinary thematic pillars: Environment, Health and Food with focus on organic contaminants, element speciation, traditional and non-traditional stable isotopes, nanoparticles and food safety, traceability and authenticity. MASSTWIN has planned management visits, short-term and long-term exchanges of early-stage and senior researchers, thematic scientific workshops/meetings, common working groups and trainings, participation at conferences, trade fairs and open days. MASSTWIN has also been aligned with the objectives of the national Smart Specialization Strategy with an aim to increase science and technology capacity of the JSI-O2. Extensive dissemination/exploitation/communication activities will be aligned with the existing ERAChair ISOFOOD project for Isotope Techniques in Food Quality, Safety and Traceability, coordinated by JSI-O2. The MASSTWIN Users group will consist of representatives of higher education, the JSI Technology Transfer Centre, industry, governmental bodies, NGO’s, and wider community through outreach activities and will therefore account for a positive impact not only on involved personnel and their knowledge, but also on institute level and create positive societal and economical impacts.

Keywords: mass spectrometry,health,environment,food,contaminants,nutrients,nanoparticles,metrology,data treatment
Common Agriculutral and wider bioeconomy reSearch Agenda (CASA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Ireland,Germany,Italy,Germany,Belgium,France,Netherlands,Denmark,Portugal
Call: Support Action to a common agricultural and wider bioeconomy research agenda (H2020-SFS-2016-1, 2016)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 2122461.25
EU funding (EUR): 2122461.25
Participants: 10
Project status: CLOSED

The overall objective of CASA is a consolidated common agricultural and wider bioeconomy research agenda within the European Research Area. The common research agenda will be jointly shared by Member States of the European Union and Associated Countries. It will improve the alignment and interoperability of the respective national research programme(s). This will be achieved through enhanced cooperation, coordination and information exchange between the Member States, Associated Countries and the European Commission. This includes increasing the opportunities for Member States and Associated Countries to engage in the aforementioned activities. The conduit for this will be the Standing Committee of Agricultural Research (SCAR) and the various SCAR working groups, through which all Member States and Associated Countries are brought together with a view to fostering cooperation, coordination and information exchange, as well as streamlining research policy, in the bioeconomy and closely related fields. The overarching aim of CASA will be achieved through the accomplishment of the following four specific objectives: 1. Increased and broadened participation, interaction and collaboration of Member States and Associated Countries 2. Improved quality of outputs and outcomes of the Standing Committee of Agricultural Research creating added value for greater impact 3. Strengthening the production of more strategic policy advice by the Standing Committee of Agricultural Research based on the increased, deepened and broadened participation facilitated by CASA 4. Improve overall organisation, communication and dissemination of SCAR activities, outputs and outcomes for greater impact

Keywords: bioeconomy,coordination,alignment,research,innovation,era net,member states,associated countries,cooperation,network,working group,interoperability,challenge,foresight,sustainabilit
Commercialisation of the world’s first iNTelligent Access Cover Technology for the protection of ALL underground infrastructure. (iNTACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: United Kingdom
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-07-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

All infrastructure that underpins life as we know it runs underground in some form whether it be telecoms, water, gas or electricity. All underground infrastructure is only accessible through one method – inspection chambers. These inspection chambers are common and 100s can exist within a small area. To prevent criminal damage to infrastructure and ensure safety, all of these chambers are covered with access covers. There have been no major innovations of access covers in recent times and most remain completely unsecure and vulnerable. Requests to increase security has resulted in simple measures taken in the form of padlocks and key-locks, which still leave significant vulnerabilities. Alongside these vulnerabilities, covers in strategic sites need daily monitoring. This is currently done manually with physical inspections. There is a significant cost incurred for this. We are Hugslock Systems and have developed a solution that will secure all underground infrastructure. We have created iNTelligent Access Cover Technology ‘iNTACT’ that will truly revolutionize the security of underground critical infrastructures. iNTACT is the world’s first remote lockable access cover. It is secure, impenetrable and intelligent. Intelligence is embedded within the cover in the form of sensors that can offer various monitoring capabilities such as gas, heat, water sensors, Infrared CCTV, motion, bio-hazard and seismic. iNTACT completely removes the need for any physical inspections, as the remote-operated locks can be remotely monitored from a central control room. We have strong market-pull from utility providers such as SITEL of the Czech Republic and organizations such the Ministry of Defence. Based on early interest we have built bottom-up 5 year forecasts to generate cumulative turnover of €28.9m to generate €15.1m PBIT. Based on total investments of €1.85m, this will achieve a ROI of 7.2:1 and payback on investment in 29.8 months.

Keywords: access cover,manhole cover,remote locking,critical infrastructure,cable theft,metal theft,prevention,protection,impenetrable,intelligent,connected
Aicraft Design and nOise RatiNg for regiOnal aicraft (ADORNO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy
Call: Aircraft design and noise assessment for a regional application (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 400000.0
EU funding (EUR): 400000.0
Participants: 2
Project status: CLOSED

Aicraft Design and nOise RatiNg for regiOnal aicraft. The activities related to the ADORNO project are focused on the development of aircraft models for a regional aircraft engine platform. The main objective is to provide aircraft requirements (e.g. thrusts, offtakes, etc.) as well as trade factors for specific fuel consumption, engine drag and engine weight on fuel burn for both a year 2000 reference aircraft and a CS2 target aircraft. In addition, an aircraft noise method will be developed and integrated in an aircraft design chain. The high-level objective of ADORNO is to allow a fast and reliable estimation of aircraft Noise and emissions in terms of CO2, NOx at different mission phases, through the implementation of a flexible aircraft model which provides requirements for the engine platform in terms of thrusts and offtakes at different power settings and flight conditions. The ADORNO high level objective is translated into the following main technical objectives: • To deeply apply the available MDO chain for aircraft design with integration of noise, emission and engine tools. • To implement a flexible A/C modeller which allows an easy integration of an external engine model to obtain an efficient and cost-effective design processes. • To implement a stand-alone tool for noise prediction which required only few inputs and could be easily customizable by users. • To provide an emissions prediction tools which required only few inputs and could be easily customizable by users. • To provide a concurrent design approach enhanced by integration of visualization tools to support the design team for the understanding of the product and its behavior during the design sessions.

Keywords: aircraft design,noise,emission,engine integration
Glass Assessment Technology for glass Embedded antennas (GATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-10
End date: 2021-10-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The advanced applications in 5G, such as Internet of Things, smart building, and smart city, are driving the growth of indoor broadband communications. Small cell is a promising technology to address capacity crunch problem in-building. Glass is a popular material widely used in modern buildings. Considering the factors of aesthetics and stability, embedding antennas into glass can be a good choice for deploying small cells indoors. However, how the glass impacts the wireless performance of a glass embedded antenna has not been well investigated. In this project, we will study the influence of EM properties of glass on the wireless performance and will design and optimise glass to achieve desirable wireless performance while maintaining acceptable optical and thermal properties. First, we will define measurable wireless performance metrics for glass embedded antennas, where the radiation efficiency, bandwidth, radiation pattern, coverage, and signal to interference plus noise ratio will be taken into account. Then, we will bridge the gap between ingredient ratios and structures of glass and the wireless performance of the embedded antenna. Three glass structures including coated glass, laminated glass and doping glass will be modeled. Finally, we will develop a method that can obtain a trade-off among wireless, optical and thermal performances of glasses. The ingredient ratio and structure of glass will be optimised in term of wireless performance under the constraints of optical and thermal performances, so that the glass can be multifunctional and smart. After this project, the benefits and feasibility of glass embedded antenna arrays can be assessed and the key technology of optimising glass embedded antennas can be established.

Keywords: antenna,glass design,electromagnetic simulation,indoor communications
Photodiode integration on silicon nitride (POTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

In this project the fellow, Gabriele Navickaite, will conceive and realize monolithic integration of semiconductor photodetectors on top of a passive Silicon Nitride (SiN) Photonic Integrated Circuit (PIC). This project will show for the first time the monolithic combination of the SiN passive platform with an active semiconductive element and thus constitutes an important step towards further integration. It clearly fills a market gap in the growing integrated photonics business. Whereas the SiN platform has obtained significant attention in the past years, because of its low loss (10 times better than silicon) and large transparency window, the application space is limited by the absence of active elements on the PIC platform. A research and business breakthrough would be the combination of the low loss SiN platform with an active material for photon detection. LIGENTEC has already gained market insights that the additional integrated functionality is desired by the end-customer and will be still affordable due to wafer scale processing. In addition to passive SiN component (see an array waveguide grating chip in Figure 1) LIGENTEC has developed fabrication processes that enable evanescent coupling of SiN to other materials. The applicant seeks to build on this development and integrate evanescently coupled photodetectors. The fellow Gabriele Navickaite together with the host company LIGENTEC proposes to reach the following objectives in the time frame of 24 months for the first time: ● Demonstration of integrated photodiodes on SiN photonic platform ● Demonstration of a packaged SiN PIC for wavelength splitting at VIS wavelengths and detecting (DEMO) This 24-month project foresees to design and simulate the integrated photodiode, develop the material and finally fabricate and test a prototype.

Keywords: silicon nitride photonics integration photodiode
Endothelial Cells - an Overlooked Non-hematopoietic cOmponent of tuMor immunitY (ECONOMY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Despite decades of research, cancer remains the second leading cause of death globally. Amongst all cancers, lung cancer is the deadliest in both men and women worldwide. Immune checkpoint blockade (ICB) recently emerged as promising cancer therapy. While extremely successful in hematopoietic cancers and melanoma, success in lung cancer is very limited. We are therefore in desperate need to devise novel treatment strategies. One approach would involve remodelling the lung cancer immune landscape to improve clinical response to ICB. A so far overlooked non-hematopoietic component of the immune system which potentially greatly contribute to tumor immunity are endothelial cells (ECs). Most intriguingly, tumor EC (TEC) subsets expressing diverse immune markers were identified, in parallel with the discovery of diverse metabolic phenotypes in TECs. The host lab identified TECs with transcriptional signatures related to antigen processing and presentation (MHCII+). However, the functional significance of MHCII+ TECs in tumor immunity and whether their immune-related functions could be regulated by underlying metabolic programming is unknown. Given the strategic "first line" location of TECs in the tissue, the question is whether, ICB’s effectiveness can be partly attributed to TEC immunity. I therefore propose to investigate the interactions between MHCII+ TECs and T cells and the effects of such interactions on tumor immunity using state-of-the-art inducible EC-specific MHCII knock-out mice. Moreover, I will assess metabolic signatures in immune-TECs and test potential metabolic regulation of TECs’ immune functions. Such metabolism-driven regulation could open new therapeutic possibilities, utilizing already available pharmaceutical inhibitors to remodel the tumor immune landscape in order to create a favourable context for immunotherapy. Thus, the proposed research is expected to pave the way for exciting new combination treatment strategies for lung cancer.

Keywords: cancer,tumor endothelial cells,immunology,endothelial cell metabolism,metabolic regulation,antigen presenting cells,cd4 t cells