Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New frontiers for coherent X-ray generation (X-HARM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-06-01
End date: 2016-05-31
Duration (months): 36.0
Total project cost (EUR): 254925.9
EU funding (EUR): 254925.9
Participants: 1
Project status: CLOSED

The present proposal outlines a postdoctoral training for Carlos Hernandez-Garcia (Experienced Researcher, ER) for two years in JILA at the University of Colorado in USA (outgoing host institution, OH), followed by a third year at the Universidad de Salamanca (USAL) in Spain (return host institution, RH). The applicant will have the opportunity to strengthen his existing collaboration with the outgoing host, which started in the form of short visits during his PhD studies. The research proposal addresses the novel challenges associated to the emerging field of intense mid-infrared laser-mater interactions. The ER, and the two host institutions, were involved in the first demonstration of efficient coherent X-ray generation from the high-order harmonics (HHG) obtained with table-top mid-infrared source, reported in Science journal in June 2012. This milestone is taken as a starting point in this proposal. The promising future of these new compact X-ray sources will be the stimulus of basic research in this field. First, there is evidence of new phenomena unique for intense-laser interaction in the mid-infrared spectral range, and secondly, it is necessary to obtain characterization schemes for the novel X-ray beams, which requires a proper analysis of the interaction of matter with coherent X-rays, including the special properties of these new sources. During his PhD, the ER has acquired experience in theoretical and experimental work on intense laser-matter interaction. The present proposal involves theoretical as well as experimental training. The proposed training is designed to develop along three different lines: designing a new generation of X-ray sources based on the results of theoretical calculations, performing a theoretical study how matter interacts with these newly designed X-ray beams towards their possible applications, and acquiring theoretical and experimental skills of special interest for the future career development of the ER in the RH.
Does Trade Multilateralism have a Future?: Reviving the WTO’s Credibility as the premier Multilateral Trade Negotiating Forum (MULTITRADE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-05-02
End date: 2014-08-01
Duration (months): 15.0
Total project cost (EUR): 142375.0
EU funding (EUR): 142375.0
Participants: 1
Project status: CLOSED

In the present climate of weak economic prospects, the developed countries have seen a growing disenchantment with globalisation and trade liberalisation. Irrespective of their stated interest in enhancing export revenue to bridge fiscal gaps, strong protectionist tendencies are surfacing. Also, the focus seems to be shifting from multilateralism, made evident from the failure to conclude the on-going Doha Round of WTO negotiations and the recent spurt in FTA negotiations worldwide. On the other hand, developments since the recent financial crisis indicates that the WTO is yet to lose it’s relevance as the multilateral referee of global trade relations, as least insofar as its rule-making and dispute-settlement roles are concerned. The laudable resilience of the global trading system and WTO institutions notwithstanding, recent experience with Doha Development Round negotiations has highlighted the need for systemic changes in WTO, in the interest of making the organisation more credible and efficient. It is in this context that this project proposes to analyse possible contours of a reinvigourated multilateral trade negotiation system and trade liberalising philosophy, one that can meet the trade challenges and political-economy realities of the 21st century. To do this, the project will look at the contours of a more constructive engagement and leadership by emerging economies (and in particular Brazil, India and China) in the international trade negotiations, especially given that the major industrialised countries have now reduced their leadership in the WTO-led multilateral trade negotiations. The project will also evaluate the acceptability of a developing-country-led negotiating template that might emerge as result. Finally, we would discuss how the WTO could be reformed to institutionalise systems and governance modalities that foster/boost dynamic comparative advantages for all Members, and the specific role of emerging markets in restoring WTO’s supremacy.

Keywords: e116 international trade - economic geography,e117 economic history - development
THRIVING IN THE WORKPLACE - SUPPORTING PEOPLE AT THE AGE OF 55 YEARS AND OVER IN SATISFYING AND PRODUCTIVE WORK (THRIVING AT 55+)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-03
End date: 2015-06-02
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 2
Project status: CLOSED

Workers aged 55+ are not always utilised or valued as much as they could be in the workplace, yet their contributions are increasingly necessary as the European population ages. Many of them need to work for longer than they expect, due to pension fund shortfalls and changes in official retirement ages. For some, this will require a change in perspective and strategies for managing self and career. The proposed project will integrate currently fragmented approaches to show how older workers experience their ageing in the workplace (including others’ perceptions of them), their strategies for dealing with it, and the consequences for their productivity and well-being. Interviews will be conducted with 40 workers aged 55+ and 8 human resource managers in four organisations in the IT sector and four in the health sector - two organisations of each type in the UK and in Bulgaria. A conceptual model will be developed and tested using mainly quantitative questionnaire data from 500 workers aged 55+ in the same two countries and sectors. This will identify how the workplace (including human resource practices) can be designed to facilitate the successful participation of older workers, and also the best strategies workers themselves can use. Case studies, guidance notes and training materials will be produced and piloted. The conduct and dissemination of the work will be achieved with the co-operation of a number of organisations that promote effective practices at work. Many are already well-known to the researcher and the host organisation. Academic papers will be published in leading journals based in Europe. Dr Stanimira Taneva is the proposed researcher. She has substantial experience in applied psychology research and in promoting the career development of diverse groups of people especially in Bulgaria. The host organisation is the Institute of Work Psychology (IWP) at the University of Sheffield, UK. IWP is renowned for its excellent research on people and work.

Keywords: career,work,ageing,productivity,well-being,human resource management,career development,united kingdom,bulgaria,training,guidance
Regulation of Expression of Staphylococcus aureus Vaccine Antigen Candidates (RESTAVAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 179739.6
EU funding (EUR): 179739.6
Participants: 1
Project status: CLOSED

Staphylococcus aureus is a commensal of the human skin and nares, and a major cause of skin, and soft tissue as well as invasive infections. Bacterial pathogenicity results from a complex interplay of virulence factors with regulatory systems that respond to multiple external signals from the host environment and the bacterial population. Currently no vaccine against S. aureus is available. Novartis Vaccines and Diagnostics (NVD) has employed the reverse vaccinology approach to identify a list of novel antigens which are now under further analysis for inclusion in a vaccine. RESTAVAC will investigate the regulatory mechanisms involved in controlling expression of these vaccine antigen candidates. By analysing the temporal expression of novel antigens and characterised reference virulence factors, through reporter fusions, in various in vitro, ex vivo and animal models, RESTAVAC will uncover regulatory responses to environmental stimuli, diverse niches or disease settings as well as the molecular mechanisms involved in their fine-tuning. This will aid in predicting the efficacy of the candidate proteins as vaccine antigens and contribute to understanding their roles in the pathogenesis of the bacterium. Secondly, analysis of global gene expression profiles in ex vivo and animal models will greatly assist in identifying critical genes important for the different disease outcomes and the regulatory networks that may be involved. Such analysis will help to unravel the complex interactions between S. aureus and its host environmental niches during disease development. And thirdly, comparative analysis of reporter gene expression in both HA- and CA- isolates from geographic, temporal and sequence-type diverse origins along with genome-wide expression profiling will shed light on fundamental differences of this emerging group of pathogens as well as understanding the patterns of gene expression of the vaccine antigen genes across diverse staphylococcal disease isolates.

Keywords: l101 molecular biology and interactions,gene regulation and transcriptomics,prevention of infection by pathogens.
New optical functions for endoscopic capsules (SMART PILL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 243847.8
EU funding (EUR): 243847.8
Participants: 1
Project status: CLOSED

The passive endoscopic capsule (EC) was invented a decade ago and has proven a major technological breakthrough in medical technology that has facilitated an unprecedented level of patient-friendly diagnosis of small bowel diseases. The propulsion of commercially available passive ECs is provided by the natural motility of the intestine, known as peristalsis. Moreover, the EC vision system uses only white-light and a CMOS imager that collects the images (2-4 frames per second). Before ingestion of the capsule, an antenna array is taped to the patient’s anterior abdominal wall and connected to a data recorder carried by the patient. This proposal addresses several innovations of the EC that would contribute to this goal. The first is the use of an active magnetic platform for guiding an EC inside the human body. The system will be composed by an external permanent magnet and inside of the EC is placed a small internal permanent magnet. The remote control of an EC by magnetic field allows the medical doctor to stop, to rotate the EC and to provide detailed images and early detection and diagnosis of the widespread diseases of the gastrointestinal (GI) tract, in particular targeting inflammatory bowel disease (IBD), gastro-esophageal reflux disease (GERD) as well colo-rectal cancers (CRC) and its precursors. Work on this objective in which applicant is involved is already on-going. The second is the exploration of advanced diagnostic imaging techniques. In addition to the conventional white-light illumination, the goal is to implement: narrow band imaging (NBI) and endomicroscopy (ENM). Finally, a therapeutic function, photo-dynamic therapy (PDT), which is a technique for clinical treatment of several types of GI cancers, is to be integrated in EC. The active EC envisaged is a genuine smart pill and will operate with two domes (front and back), the front dome with white light LEDs, NBI and PDT functions and the back dome of the capsule dedicated to the ENM function.

Keywords: optical microsystems,endoscopic capsules,narrow-band-imaging,photodynamic therapy,microscopy
VEry LOw jitter MOde LOcked laser at 780nm for optical sampling applications (VELO MOLO_780)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-02
End date: 2015-09-01
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The project investigates prospective configuration of pulsed laser source for the use in photonic assister analog to digital converters. This application oriented project is based on strong interdisciplinary linkage and aims to develop compact, efficient and low cost pulsed sources. System requirements for a pulsed laser source are to be met by means of mode-locking from either monolithic laser diode or fibred external cavity system. The core of this project is based on an iterative process of multiple runs and each represents the full process which combines different skills and procedures which include the design, fabrication, testing, modelling and the delivery of an improved design. Throughout the project, the fellow, who owns a solid academic background in laser physics will have the opportunity to perform industrial research and development in a fertile and diversified scientific environment provide by the host institution. This environment will stimulate the fellow to reach professional maturity. This application oriented research will contribute to the European Excellence in the field of photonics.

Keywords: g205 micro- and nanoelectronics - optoelectronics,g206 communication technology - high-frequency technology,p207 semiconductors
Genetic mapping of complex trait intermediates (INTGENMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-03-01
End date: 2015-05-31
Duration (months): 27.0
Total project cost (EUR): 167249.02
EU funding (EUR): 167249.02
Participants: 1
Project status: CLOSED

Many important traits are heritable, and have a strong genetic component. Numerous genome-wide association studies of common human diseases have corroborated that no single gene explains all or even a large part of their heritable variability. Each effect of a single locus genotype on such a global trait has to be mediated by cellular, tissue, and organ phenotypes. Thus, genetics of intermediate cellular traits is central to developing an understanding of the genetic basis of complex traits. Studies in model organisms, where causality can be addressed by reverse genetic tools, are required for mechanistic understanding of these phenotypes. We aim to develop most powerful ways to understand the mechanism of moderate effect genetic variants in yeast Saccharomyces cerevisiae. The effect of genetic variation is via protein sequence, level, and localisation, as well as metabolite concentrations. Thus, we seek to assay all these traits on large scale to trace the effect of alleles contributing to a global complex fitness phenotype. The measurements will be made from very large pools of genetically diverse individuals using cutting edge assays, measuring either population average in low throughput, or many individuals in medium throughput. We will then compare genetically adapted and reference populations to understand which traits underlie the complex fitness, how the alleles that have moderate effects on the global trait contribute, and where potential targets for modulation lie. This project combines state of the art cellular assays with leading methods for genetic mapping to understand mechanisms behind complex traits. The intermediate traits have not been mapped with high power thus far in any organism. The project will result in a researcher trained at the intersection of quantitative analysis and experimental genomics, and deliver methods for understanding mechanism of alleles with small effect sizes, for both of which there is an acute need.

Keywords: l802 population biology - population dynamics - population genetics,l207 quantitative genetics,l201 genomics - comparative genomics - functional genomics,l211 computational biology
Of DNA methylation and looping of distant regulatory elements in mantle cell lymphoma (DNAMETHYLOOPMCL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-02-01
End date: 2016-05-22
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

B-cell differentiation is a complex process in which epigenetic changes, i.e., DNA methylation and histone modifications, play an essential role to regulate gene expression. Disturbances in epigenetic processes can result in development of B-cell malignancies, such as mantle cell lymphoma (MCL). So far, little is known about the epigenetic alterations underlying MCL. In general, epigenetic studies in cancer have mainly dealt with identification of hypermethylated promoter regions. Recent genome-wide studies in B cell malignancies however, have shown that the majority of DNA methylation changes do not occur in promoter regions but at intra- and intergenic loci, which are enriched for enhancers. In this project, I wish to study the functional impact of DNA methylation changes at these enhancer regions on DNA looping and gene expression regulation in MCL. To achieve this goal, I will generate genome-wide chromosome conformation maps of MCL and normal naive B cells using Hi-C sequencing. Additionally, I will generate DNA methylation profiles, histone modification maps and gene expression profiles of these samples. Combining these datasets will allow identification of intra- and intergenic enhancer regions that, based on differences in DNA methylation status, affect DNA looping and gene expression. The effect of DNA methylation on enhancer activity of these regions will then be studied in further detail using luciferase reporter assays. The proposed study shall give insights into (i) the effect of DNA methylation outside promoter regions on DNA looping and gene expression (fundamental aspect); (ii) the DNA methylation changes in MCL that affect these processes (biological aspect); and (iii) the functional impact of differential DNA methylation between MCL subtypes (clinical aspect). The latter 2 shall lead to better understanding of the underlying molecular mechanisms of MCL and may form a basis to design new therapeutic strategies for this aggressive disease.

Keywords: dna methylation,enhancers,dna looping,gene expression regulation,mantle cell lymphoma
Dissecting Cancer Development by Chromothripsis Using Cell-Based Models (BRM CHROMOTHRIPSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Cancer is commonly thought as a progressive process, requiring accumulation of many mutations over time. Recently, this conventional view of cancer progression has been challenged with the discovery of a phenomenon called chromothripsis, whereby tens to hundreds of chromosomal rearrangements occur in a single catastrophic event. Despite the growing amount of sequencing data that sheds some light on the nature of these structural variations, the molecular mechanisms behind these detrimental alterations are unclear. Here, I propose a research project aiming to decipher the mechanistic basis of chromothripsis. I will generate human cell lines with various genetic backgrounds that are prone to accumulate persistent DNA damage. With these cell lines in hand; I will systematically analyze the possible mechanisms leading to massive chromosome breakages. I will use laser microdissection to isolate the cells with potential chromosome breakages and further analyze them with flow karyotyping and deep sequencing. The experimental part of the proposed project will be complemented with detailed analyses of the existing genomic data in order to pinpoint mutations that could lead to chromothripsis. Together, this project will provide critical information on the molecular mechanisms behind this newly discovered catastrophic event and contribute to the understanding of cancer progression.

Keywords: cancer,chromothripsis