Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable and cost-efficient Concepts enabling green power production frOM suPercriticAl/Superhot geothermal wellS (COMPASS) (COMPASS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Iceland,United Kingdom,Netherlands,Norway,France,Italy
Call: Solutions for more sustainable geothermal energy (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 4184145.0
EU funding (EUR): 4184145.0
Participants: 10
Project status: SIGNED

The COMPASS project is inspired by global efforts to improve utilization of geothermal resources by enlarging production fields downwards. Energy output can be enhanced, without the need to expand surface infrastructure, by drilling into deep and hot formations. Calculations indicate that wells drilled into superhot conditions will yield 5-10 times more than a conventional well which can significantly reduce number of wells required. The main challenges to achieve this are related to the well integrity; due to extreme temperature changes and corrosive fluid chemistry encountered. Two of three wells in the Iceland Deep Drilling Project (IDDP) have already been drilled and had serious problems with casing failures. Numerous examples of casing failures in conventional geothermal wells show that current well concepts, mainly transferred from oil and gas applications, are barely sufficient for geothermal use. COMPASS will address these challenges by developing improved and innovative well casing technologies: -To mitigate casing failures, novel foam cement solutions will be developed suitable for high temperature formations. This system would work with available flexible couplings to mitigate high-temperature induced stresses and ensuring well integrity. - Cost-effective laser-cladding will be used to improve corrosion protection inside the casing pipes. These technology developments will be enhanced with a robust well design solution addressing challenges, reducing project risk and enabling reduction of LCOE. The new well concept will enable cost-effective geothermal developments in new types of geological settings and new regions. The COMPASS consortium contains a diverse team of major geothermal research institutes and leading industry players. This combination ensures cross-fertilisation, sharing of knowledge and experience, and seamless transfer of the novel well construction technologies by industry application, including significant citizen e

Keywords: geothermal well design,deep drilling,iddp,well casing,novel foam cement,flexible coupling,laser cladding
High Performance Computational Methods for the Boltzmann Equation (HYPERBOLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-05-31
Duration (months): 29.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

The Boltzmann equation is highly important in mathematical modeling of physical systems large and small, from galactic dynamics to electron transport. Its range of applicability exceeds that of well-known continuum models, such as the Navier-Stokes-Fourier equations. In particular, the Boltzmann equation can accurately predict rarefied gas phenomena, which occur in a wide variety of high-tech 21st century applications, such as microelectronics, plasma physics, and high altitude flight. While numerical methods for continuum models are well established, numerical methods that accurately and efficiently solve the Boltzmann equation are undeveloped. The main objective of this research proposal is to enable three-dimensional numerical simulation of rarefied flows by developing accurate and efficient numerical solution procedures for ``the method of moments'' to numerically solve the Boltzmann equation. The approach described herein is innovative and original as it is the first to exploit Kronecker structure and structural properties of the Boltzmann equation to improve efficiency. The developed techniques will be consolidated into a high performance computing framework and applied, for the first time, to an industrial photolithography application. The proposed research involves a private-public partnership between domain experts in ``the method of moments'' at the Technical University of Eindhoven (TU/e) and experts in ``photolithography'' at ASML. If awarded, this proposal will allow me to lay the groundwork necessary to achieve a paradigm-shift in numerical simulation of rarefied gas flows. It could emanate into a successful line of research for the coming decade, with academic as well as commercial interests aligned with my career goals. I am highly motivated and uniquely positioned to carry out this research due to my specialistic expertise in efficient solution methodologies and my interdisciplinary training in mathematics, computational science and engineering.

Keywords: kinetic theory boltzmann equation numerical simulation computational fluid dynamics method of moments kronecker products high performance computing
How to evolve without centromeres: meiotic recombination dynamics in holocentric plants (HoloRECOMB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1499980.0
EU funding (EUR): 1499980.0
Participants: 1
Project status: SIGNED

Centromeres strongly affect genomic architecture and meiotic recombination distribution and also play a key role in constraining karyotype evolution. The recombination landscape is also heavily influenced by chromosome number and structure (i.e., karyotypes), as at least one crossover per chromosome (and rarely more than three) occurs in most species, making chromosome number the primary driver of recombination frequency. In addition, centromeres inhibit recombination, and therefore crossovers tend to occur mostly at chromosome ends. However, several unrelated eukaryotic lineages do not have centromeres, or at least, not conventional ones. Such is the case for plants with holocentric chromosomes, where hundreds of small centromere-like units are evenly distributed across the length of the chromosome. Notably, holocentricity has evolved repeatedly across the tree of life and at least four times during plant evolution. Holocentric plant species offer a unique opportunity to study the plasticity of meiotic recombination control. These species have lost typical centromeres, making them ideal for investigating how the recombination landscape was reshaped after the transition to holocentricity. Moreover, holocentricity unleashes changes in the karyotype, offering the possibility to analyze the effects of chromosome breaks and fusions on recombination frequency and distribution. The HoloRECOMB project aims are as follows: I. Analyze how transitions to holocentricity affect meiotic recombination dynamics in different holocentric plant lineages. II. Explore the effect of chromosome breaks and fusions on crossover number and distribution. III. Examine whether the crossover regulation in holocentric plants acts in a similar manner as in monocentric ones. Understanding how holocentricity affects recombination dynamics will provide insights into important mechanistic aspects of meiosis with potential practical applications for crossover regulation in centromeric regions.

Keywords: centromere,holocentric chromosome,chromosome breaks and fusions,meiotic recombination,crossover,recombination landscape,karyotype evolution,crispr,chromosome engineering
Paramagnetic, fluorinated and water-soluble metal complexes for 19F MRI (PARA-FLUOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

19F MRI relies mainly on the use of fluorine-dense perfluorocarbon nanoemulsions. However, poor water solubility, limited stability, droplet heterogeneity, rigorous liver accumulation of the particles, as well as the relatively long fluorine relaxation times often limit their applicability. Fe(III) and Mn(II) have the most advantageous paramagnetic properties to shorten T1 relaxation time of 19F without strong line-broadening T2 effect, deleterious for 19F MRI detection. The combination of these paramagnetic metal ions with small molecular weight ligands containing maximized number of magnetically equivalent fluorine atoms is proposed here to circumvent the problems associated with perfluorocarbon nanoemulsions. We will create complexes that provide high thermodynamic stability and kinetic inertness important for safe biological application, good water solubility, as well as short 19F T1 relaxation time, allowing for fast MRI scans and high signal to noise ratio. A series of open-chain and macrocyclic ligands will be synthetized and their Mn(II) and Fe(III) complexes characterized with respect to their application as 19F MRI agents (water solubility, thermodynamic and kinetic stability, 19F relaxation properties). Structural variations of the ligands will allow for optimizing the 19F-metal distance for optimized relaxation effect. For a proof of concept cell labelling study, we will choose dendritic cells (DC) and T lymphocytes (TL), two cell types frequently used for adoptive cell transfer strategies in oncology. Cytotoxicity and cell labelling capacity of the probes will be assessed and in vitro MRI phantom images will be acquired on cells labelled with the paramagnetic complexes.

Keywords: 19f mri,mn ii,fe iii,cell labelling and tracking
On-chip tomographic microscopy: a paraDIgm Shift for RevolUtionizing lab-on-a-chiP bioimaging technology (DISRUPT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Spain,Italy
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 3018312.5
EU funding (EUR): 3018312.5
Participants: 6
Project status: SIGNED

DISRUPT aims at revolutionising the field of biomedical imaging by developing a radically new lab-a-on-chip technology: integrated tomographic microscopy. This unprecedented technique will be enabled by pushing forward the science of on-chip wireless photonics and tomography, in combination with microfluidics and artificial intelligence (AI). The CMOS compatibility of this technology represents a paradigm shift as it assures the realization of tomographic microscopes that are dramatically cheaper, lighter, and smaller than current approaches. Moreover, the singular features of the proposed solution introduce key advantages in terms of resolution, sensitivity, throughput, parallelisation, and energy efficiency. To illustrate its potential, we will show that on-chip TPM can be used for cancer detection and the identification of infected cells. Developments related to fundamental nanoantenna and diffraction tomography science, nanophotonics, nanofabrication, microfluidics, AI and clinical validation will be undertaken by a consortium comprised by 2 SME, 1 HE, 1 Non-profit RO and 2 Cancer R&D Medical institutions, with complementary expertise, leaders in their respective markets and R&D fields. This novel device is suited for many applications, such as early cancer diagnosis, cell characterisation, research on cancer and infectious diseases, immunocyte phenotyping, stem cell multipotency identification, tissue pathology, haematopathology, and analysis of infected cells. Its intrinsic mass-producible, compact, low-cost, mechanically robust, and energy-efficient feature makes this technology a future innovation driver for new developments in many biomedical application fields, and offers an alternative toolset addressing some of the emerging needs of microscopic analysis and diagnostics in low-resource settings, telemedicine applications and point-of-care, having a potentially huge societal impact fostering early diagnosis of cancer and other diseases and infections.

Keywords: bioimaging,tomographic microscope,lab on a chip,wireless photonics interconnects,cancer diagnosis,cellular research,microfluidics
Dissecting the neutrophil-cancer cell interactome in the metastatic bone niche (ProMetNeu)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Bone is one of the most common organs for solid tumour metastasis. 75% of patients with late-stage breast cancer develop recurrence in bone. Current treatments are palliative, leaving this condition incurable, with an unmet need to identify new therapies. Inflammation is an important player in cancer. My pilot data show that depletion of a specific immune cell type, neutrophils, impairs bone metastasis in vivo, suggesting that neutrophils have tumour-supporting functions. However, the role of neutrophils in the metastatic bone niche remains largely unexplored, it is unknown whether they contribute to the seeding or the expansion phase of bone metastasis and if tumour cells regulate neutrophil plasticity, therefore skewing the balance towards pro-tumourigenic neutrophil subsets. I hypothesise that neutrophils acquire pro-tumourigenic phenotypes when in close proximity to cancer cells and support metastatic progression by regulating the tumour niche. By using a liposoluble fluorescent protein expressed by cancer cells, neighbouring neutrophils will be characterised: Neutrophil subsets will be identified by spectral cytometry, their transcriptomic signature analysed using RNA sequencing and their pro-tumourigenic role functionally assessed in vitro and in vivo. By employing a combination of MALDI-MSI and multiplex antibody-based imaging, neutrophil-cancer cell interactome will be established in order to identify candidate molecular mechanisms regulating neutrophil pro-tumourigenic functions. By using in vivo models of neutrophil extracellular traps (NETs) blockade, neutropenia, neutrophilia and enhanced neutrophil retention in the bone marrow, neutrophil candidate mechanisms shaping the metastatic niche will be determined. Dissecting the molecular mechanisms regulating pro-tumourigenic neutrophil subsets is fundamental to identify novel means of inhibiting bone metastasis without affecting neutrophil critical functions in inflammation.

Keywords: neutrophils,bone metastasis,tumour niche,breast cancer
Therapeutic Antisense Oligonucleotides Targeting NUMB Alternative Splicing in Lung Adenocarcinoma (TAONas-LUAD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,France,Norway
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-04-01
End date: 2025-12-31
Duration (months): 45.0
Total project cost (EUR): 2899553.25
EU funding (EUR): 2899553.0
Participants: 4
Project status: SIGNED

Lung cancer is the leading cause of cancer-related deaths, with 1.8 million deaths expected globally in 2021. Lung adenocarcinomas (LUAD) represent 1/3 of all lung cancer cases. Despite notable advances, current treatments remain ineffective, resulting in <25% survival beyond 5 years. Due to the high heterogeneity of molecular abnormalities driving lung cancers, targeted therapies are applicable to only a small subset of patients. There is therefore an urgent unmet need for developing novel therapeutic approaches generally applicable to LUAD patients. Alternative pre-mRNA splicing (AS) allows the synthesis of different protein variants from a single gene by differential selection of exonic sequences. Increased inclusion of exon 9 of the gene NUMB encodes a protein isoform that promotes cancer cell proliferation. This occurs in the vast majority of LUAD tumours, correlating with worse disease prognosis. Supported by the ERC PoC VALSL, we developed an innovative therapeutic approach based on the use of Antisense Oligonucleotides (AONs) that regulate NUMB AS. Our proprietary AONs correct NUMB pathological splicing, inhibit cancer cell proliferation and reduce tumour growth in four different mouse models of LUAD, including 2 Patient-Derived Xenograft models. With support from the EIC Transition, we will bring this technology to a stage where it is ready to be validated in clinical trials. We will optimise our lead AONs by improving their chemistry, formulation and administration and will carry out regulatory pre-clinical studies. These will pave the way to the first application of AON-based splicing modulation in clinical oncology. To commercialise this technology, we also aim to develop the business plan for a spin-off company, AON Therapeutics. In the long term, our project has the potential to generate compounds, presentations and delivery methods that can be applicable to other target AS events and/or cancer types, as well as to other AS-related diseases.

Keywords: rna,cancer,lung,therapeutics,splicing,oligonucleotide,antisense
Business Intelligence Engine for Things in Motion (NAVALGO)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

NavAlgo is building a Business Intelligence engine for Things in Motion. Tailored for transport & logistics, it allows users to extract valuable insights from the growing amounts of spatio-temporal data that is being generated (from IoT devices but not only), to improve operations, reduce costs, & meet the challenges of the digital & sustainability transitions. The solution - a horizontal B2B cloud-native application - enables companies to: face the data deluge they experience & to make a strategic use of their data with a very short time-to-market, by turning raw (unqueriable, often inconsistent) data on assets’ movement & transport parameters into a reliable vision of their process; focus their attention on actionable insights related to their supply chain processes, covering anomaly detection, forecasts, and risks of delay or damage. The solution responds to the growing Business Intelligence needs of companies working with sources of Complex Data - with a special focus on data originating from moving assets (including their location). It is a complete technology stack, which - upon deployment - is meant to be accessible to users without technical skills (e.g. sales / business teams). The solution allows clients to retain full control of their data. Its main societal and economic impact lies in helping to achieve more resilient, optimized and environmentally friendly supply chains. NavAlgo is a women-led company (both the CEO and COO identify as women). A deeptech project whose development started in early 2020, this application aims to reinforce aspects of go-to-market, including IP strategy, customer validation for the primary vertical (transport & logistics), market analysis for further verticals, as well as input to the funding strategy.

Keywords: artificial intelligence,machine learning,analytics,business intelligence,things in motion,logistics,supply chain,deeptech,complex data,spatio temporal data
Technological intervention for development of circular agri-food system to produce proteins from minor cereals (ProCereal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

Clean-label plant proteins have gained a lot of financial, research, and consumer attention globally, fostering a great interest of food scientists in exploring various alternative plant sources and technologies to fabricate protein-rich food products. Cereals being the major nutrient vehicle for the masses and proteins being the second most abundant nutrient in these minor cereals, these grains can be a suitable alternative for plant-based proteins, to meet the increased protein demands. The United Nations' Food and Agriculture Organization (FAO) has declared 2023 the "International Year of Millets” and owing to its invaluable contribution to the world's food supply, not only millets but also other minor cereals are currently undergoing a revival. When other grains fail due to rising global temperatures, such minor cereals that can withstand drought are anticipated to provide food for the entire world's population. Thus, the overall aim of ProCereal is to generate high-quality cereal proteins by transforming minor cereal flours (like millets) with a zero-waste approach. ProCereal will employ novel green technologies to obtain high-value protein ingredients for food applications and the side-streams produced in the process would be explored for their potential for other high-value ingredients. This will allow the generation of new sustainable value chains for minor cereals like millets.

Keywords: minor cereals millets protein production green technologies zero waste allergenicity techno economic analysis life cycle analysis