Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hyper-emotionality after neurodegenerative loss of inhibition of the amygdala (URBACH-ALZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 173634.0
EU funding (EUR): 173634.0
Participants: 2
Project status: CLOSED

I propose to test how hyper-anxiety in Alzheimer's disease (AD) patients is caused by neurodegeneration in the amygdala, our "center of fear", by comparing with a unique group of Urbach Wiethe disease (UWD) patients with bilateral neurodegeneration of the amygdala (BLA) for which I also construct an animal model. UWD is caused by a very rare genetic mutation occurring in only a handful of individuals worldwide. My host in Lausanne has gained access, however, to a uniquely large group of UWD patients in South-Africa (>40) where the mutation has spread for 400 years in Dutch settlers. Our collaborators at Cape Town University have found, in anatomical & functional MRI and special behavioral tests, how specific loss of inhibitory projections from the basolateral (BLA) onto the central part of the amygdala (CeA) causes hyper-anxiety in UWD. Based upon recently reported BLA neurodegeneration in AD patients, I hypothesize a crucial BLA role in hyper-anxiety of AD patients. I plan to test this in AD patients with clinical collaborators in Lausanne and, to test this hypothesis causally, I have started to opto,- anc chemogenetically decrease BLA function in an animal model. In addition, in Lausanne a stronger hyper-anxiety was observed in AD patients with insecurely attached personality profiles. As my host lab has established an inhibitory role of oxytocin (OT) in the CeA, I hypothesize a decreased OT signaling in CeA of these patients, adding to the anxiety already caused by the BLA loss. I plan to test this both in AD and UWD patients by correlating attachment profiles with OT levels (in blood & cerebrospinal fluid) and anxiety levels & BLA damage (MRI). I will use opto&chemogenetic targeting of OT signaling in animals for a causal relation. This multidisciplinary and translational approach can give a deeper understanding of the role of the amygdala in hyper-anxiety in human patients, and provide a firm neurobiological basis for applying OT to treat anxiety disorders.

Keywords: alzheimer s disease,urbach wiethe disease,basolateral amygdala,central amygdala,fear,anxiety,oxytocin
EPOS Implementation Phase (EPOS IP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Ireland,Iceland,Germany,Spain,Spain,Italy,Greece,Switzerland,Norway,Türkiye,Finland,Finland,Greece,Poland,Sweden,Sweden,Türkiye,Hungary,Belgium,Greece,Poland,Poland,Romania,Slovenia,France,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 31034491.21
EU funding (EUR): 18374344.0
Participants: 64
Project status: CLOSED

The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists – the understanding of stratigraphy (the timing and distribution of layers of sediment on Earth) and the discovery of the concept of plate tectonics being among the most significant. Our ability to monitor the Earth is rapidly evolving through development of new sensor technology, both on- and below-ground and from outer space; we are able to deliver this information with increasing rapidity, integrate it, provide solutions to geological understanding and furnish essential information for decision makers. Earth science monitoring systems are distributed across Europe and the globe and measure the physico-chemical characteristics of the planet under different geological regimes. EPOS will bring together 24 European nations and combine national Earth science facilities, the associated data and models together with the scientific expertise into one integrated delivery system for the solid Earth. This infrastructure will allow the Earth sciences to achieve a step change in our understanding of the planet; it will enable us to prepare for geo-hazards and to responsibly manage the subsurface for infrastructure development, waste storage and the use of Earth’s resources. With a European Research Infrastructure Consortium (ERIC) to be located in Rome (Italy), EPOS will provide an opportunity for Europe to maintain world-leading European Earth sciences and will represent a model for pan-European federated infrastructure.

Keywords: solid earth science,research infrastructure integration,data and service provision,open access
Building an interactive AgriDemo-Hub community: enhancing farmer to farmer learning (AgriDemo-F2F)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Austria,Belgium,Sweden,Greece,Poland,Serbia,Belgium,France,France,Netherlands,United Kingdom,Denmark,Denmark
Call: On-farm demonstrations: deepening farmer-to-farmer learning mechanisms (H2020-RUR-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-06-30
Duration (months): 30.0
Total project cost (EUR): 1985363.75
EU funding (EUR): 1985363.75
Participants: 16
Project status: CLOSED

The overall aim of AgriDemo-F2F is to enhance peer-to-peer learning within the commercial farming community. The project will utilize the experience of different actors and involve practitioner partners throughout the project to deepen understanding of effective on farm demonstration activities (multi-actor approach). In a first step, we will conduct a geo-referenced inventory of open commercial farms that engage in demonstration activities in Europe, detailing the sectors, themes and topics on which they provide expertise, and describe the mediation techniques they apply. Case studies will be selected to perform an in-depth comparative analysis. Important dimensions in selection are: 1) a wide-spread geo-graphical coverage within Europe, 2) representative for EU-agricultural sectors, systems and territories and 3) low tech versus high tech in mediation techniques. Case studies will be described, analysed and compared on 1) their network structure (actors, roles and governance characteristics), and 2) the mechanisms and tools used for recruitment, interaction and learning. Furthermore, effectiveness of the different approaches within the case-studies will be assessed through an evaluation of the extent and nature of learning. Both regional and international multi-actor meetings will use the results of the cross comparative case study analysis to i) identify a set of best practical approaches for both the on farm demonstration of research results (science driven) and the spreading of best farming practices among practitioners (innovation driven) and ii) recommendations for AKIS governance and policies on how to support effective on farm demonstration activities. The empowerment of both the commercial farming and policy community to uptake these best practices will occur through structuring the project results and farm demo showcases on the AgriDemo-Hub, an interactive, user oriented, web-map application.

Keywords: peer to peer learning,agridemo hub,on farm demonstration
Dramatic hardware and energy savings in computer servers by doubling memory capacity and bandwidth using novel general-purpose compression (MaxiMem)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2021-10-31
Duration (months): 30.0
Total project cost (EUR): 1387462.5
EU funding (EUR): 971223.75
Participants: 1
Project status: CLOSED

Technology and computer applications require the use of massive and growing amounts of data. Random Access Memory (RAM) has a direct impact on how many programs can be executed at the same time and how much data is readily available. Advanced applications may be limited by memory bottlenecks. More (effective) memory capacity is needed, more cheaply. Data centres now consume 3% of the global electricity supply and account for 2% of total greenhouse gas emissions. This consumption is expected to triple in the next decade and may even reach 20% of the world’s energy in 2025. This is unsustainable. MaxiMem is the solution. It is a patented compression technology that is capable of storing and transporting information in computer memory as densely as possible, doubling memory capacity, bandwidth, speed and performance and potentially halving current energy expenditure. It is an IP block that can be installed on the System on Chips (SoCs) of servers, smartphones, tablets, computers and high-performance computers. Servers are our main (though not only) targets at market launch due to the sector growth and high cost saving potential. Server manufacturers could save up to 50% of memory costs and 25% of total hardware costs. Chip innovations like ours are normally evaluated through installation of hardware or a layout design on a chip, which is costly and slow. ZeroPoint will use its experience to develop business-enabling tools to realistically simulate a chip implementation of our IP within the customer’s architecture. These tools will be crucial to bring our IP technology to market. ZeroPoint was created in 2016 as a spinout from Chalmers University of Technology. We are now participating in the important EuroEXA project. SME Instrument support will greatly reduce our time-to-market of the MaxiMem project, which has an internal return rate of 155% (4 years), a Net Present Value of €32.3 in Year 4 of commercialisation, and an EBITDA the same year of €23.6 m.

Keywords: memory compression,energy efficiency,data compression,memory capacity,servers,random access memory,effective memory,system on chips,smartphones
Fe complexes for Reduction/Oxidation Catalysis (Fe-RedOx-Cat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 159126.0
EU funding (EUR): 159126.0
Participants: 2
Project status: CLOSED

The Fe-RedOx-Cat project aims to introduce a new family of efficient, robust and selective iron-based electro-catalysts for both, CO2 reduction and H2O oxidation. Taking into account the detrimental environmental effect of CO2 (global warming), the development of new technologies for its valorization (for instance conversion to fuels) is becoming mandatory for our society. The target catalysts prosposed in the Fe-RedOx-Cat project are based on N-heterocyclic carbenes (NHCs) as ligands, which matches perfectly with the research background of the candidate. During the first part of the project at the University of North Carolina at Chapel Hill (USA), the researcher will learn a wide range of electro-analytical techniques for the characterization/optimization of the new catalysts and also for its mechanism elucidation. Later, the new acquired skills will be transferred to the host group in Europe at ICIQ (Spain). This group will also provide his expertise in the development of catalysts based on first row transition metals and mechanism elucidation by means of experimental techniques and computational methods. The afore-mentioned features of the applicant and the host groups will provide an outstanding synergy between all the participants. Hence the researcher will embark on a challenging work plan, learning new concepts in electro-catalysis and first row transition metal catalyst design, essential for the development of the project. Moreover, the Fe-RedOx-Cat project will provide to the applicant an excellent training in the multidisciplinary research area of CO2 valorization. Altogether, the Fe-RedOx-Cat project will enhance multiple competences of the researcher on scientific and transferable skills, thus stimulating his evolution as a scientist and contributing to the growth of the European research excellence.

Keywords: co2 reduction,h2o oxidation,fe catalysts,mechanism,homogeneous catalysis
Hypertension Susceptibility in African Migrants: Solving the puzzle through transcontinental prospective cohort study design (Pros-RODAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1999438.0
EU funding (EUR): 1999438.0
Participants: 1
Project status: SIGNED

Hypertension is the most important modifiable cardiovascular risk factor. Migrants, especially people of Sub-Saharan African heritage, are extremely affected for reasons that are unclear. This project aims to understand the mechanisms underlying the high risk of hypertension among African migrants by assessing the role of epigenetic modifications that result from rapid socio-environmental and behaviour change. To achieve this, Agyemang and his team will establish an innovative transcontinental prospective cohort study of a homogeneous group of Sub-Saharan African migrants (Ghanaians) living in the Netherlands and non-migrant Ghanaians living in rural and urban Ghana. We will first examine and identify the key changes in modifiable environmental factors influencing the high risk of hypertension among migrants. Second, we will examine changes in epigenetic modifications and their effects on hypertension risk in migrants. Third, we will identify the key environmental factors that are driving the epigenetic changes. Last, we will estimate for the first time the individual and combined effect of environmental factors, and epigenetic modifications to the high risk of hypertension in migrants relative to non-migrant Europeans and Ghanaian counterparts living in Africa. This project will yield new insights into the key drivers of hypertension and deliver a major breakthrough in knowledge about prevention and treatment among African and other population groups.

Keywords: migration and health,sub sahara africa,hypertension,lifestyle,psychosocial factors,social determinants of health,epigenteics,intercontinental prospective cohort
Towards a new generation of plant-inspired growing artefacts (GrowBot)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Israel,Germany,Spain,Italy,France,France
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6997482.5
EU funding (EUR): 6997482.5
Participants: 10
Project status: SIGNED

GrowBot proposes a disruptively new paradigm of movement in robotics inspired by the moving-by-growing abilities of climbing plants. Plants are still a quite unexplored model in robotics and ICT technologies, as their sessile nature leads to think that they do not move. Instead, they move greatly, on a different time scale, purposively, effectively and efficiently. To move from one point to another, plants must grow and continuously adapt their body to the external environmental conditions. This continuous growth is particularly evident in climbing plants. By imitating them, the GrowBot objective is to develop low-mass and low-volume robots capable of anchoring themselves, negotiating voids, and more generally climbing, where current climbing robots based on wheels, legs, or rails would get stuck or fall. Specifically, the ability to grow will be translated by additive manufacturing processes inside the robot, which creates its body by depositing new materials with multi-functional properties, on the basis of the perceived external stimuli (without a pre-defined design). Energy efficiency will be intrinsic to such approach, but novel bio-hybrid energy harvesting solutions will be also implemented to generate energy by interfacing soft technologies with real plants. Perception and behavior will be based on the adaptive strategies that allow climbing plants to explore the environment, described mathematically after experimental observations. GrowBot would contribute to consolidate this ground-breaking and pioneering research area on plant-inspired robotics that, although still in its infancy, can represent a revolutionary approach in robotics, as it has already happened with plant-inspired solutions in material science. GrowBot is based on a strongly interdisciplinary character and can open the way for a new technological paradigm around the concept of growing robots, fostering a European innovation eco-system for several high-tech sectors.

Keywords: bioinspired robotics,soft robotics,plant biology,energy generation,soft materials
Improving resource efficiency through a protective film for hose reel irrigation (PROTECTOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2020-12-31
Duration (months): 29.0
Total project cost (EUR): 1511709.0
EU funding (EUR): 1058196.3
Participants: 1
Project status: CLOSED

Hose reel irrigation systems are a type of sprinkler irrigation that is portable and adapts to fields irregularly shaped or with obstacles. Farmers are increasingly demanding hose reel irrigators with long hoses (up to 1,000 m) but the high friction between the hose and the ground is troublesome and make it necessary to use heavy tractors and thick hoses. The energy for pumping water (and hence operation costs, fuel consumption and greenhouse gas emissions) directly depends on the thickness of the hose. Breakdowns and lifespan are also related to friction because it is the responsible for traction efforts on the hose and wear and tear. Irriland has over 24 years of experience in automatic hose reel irrigators, being one of the world leaders in the sector. In 2013, and based on the client’s feedback, Irriland started developing PROTECTOR. This is a disruptive and robust technology which, neither adding difficulties nor delaying the process, reduces 90% of friction between the hose and the ground. The energy consumption is therefore reduced (around 22% for pumping water and 40% for deploying and removing the hose) as well as greenhouse gas emission (around 20%). Half the plastic is used in hoses, which turn more manageable and double their lifespan (20 years instead of 10). At the same time, all breakdowns caused by tractor efforts are avoided and irrigation is possible in more conditions (rainy times, muddy grounds, etc.). We have patented our technology in our main target markets and 22 irrigation systems sellers or farmer have explicitly shown their interest in the project. With PROTECTOR we forecast an accumulated sales revenue of € 10 million by 2024 with net profits of € 3.5 million by that same year. Our headcount will increase with 26 new direct jobs and we will consolidate our position in irrigation and will lead the way towards more efficient and sustainable hose reel irrigation.

Keywords: resource efficiency,fuel savings,water savings,hose reel irrigation,protector film,sprinkler irrigation,irrigation accessory,hose friction,water efficiency,irrigation efficiency
intelligent Water Treatment Technologies for water preservation combined with simultaneous energy production and material recovery in energy intensive industries (intelWATT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Jordan,Greece,Greece,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Preserving fresh water: recycling industrial waters industry (H2020-LCCI-2020-EASME-singlestage, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 12515256.25
EU funding (EUR): 10308277.38
Participants: 21
Project status: SIGNED

IntelWATT aims to develop innovative, cost efficient, smart separation technologies applied in energy and water intensive industries. The goal of the project is to demonstrate 3 TRL7 case studies that will achieve water preservation along with energy production and material recovery. The proposed solutions will also target at zero liquid discharge while implementing maximum water reuse. Tailor made sensors and automated decision making mechanisms will optimize the process conditions in real time. The case studies will be implemented in crucial EU and global industrial applications such as electricity production, mining and metal plating. -Case study 1:Demonstration prototype for CTBD treatment. The development of efficient, cost effective, smart solutions for water management in a thermoelectric power plant, aiming at minimization of the cooling tower blow down (>99% recovery) trough developing a pilot unit of 100 m3/day treatment capacity installed in the premise of PPC’s unit V (natural gas combined circle facility, Megalopolis, Greece) based on a closed loop, near zero liquid discharge approach. -Case study 2: Demonstration of a symbiotic concept between industries: sustainable production of energy and water. In this context, an integrated pilot unit (100 m3/day) comprised by Reverse Electrodialysis (RED) and solar powered membrane distillation (MD) systems. -Case study 3: The application of a novel, hybrid high recovery RO (HRRO) / Ion exchange (IX) resin prototype will demonstrate the recovery of valuable electrolytes and fresh water preservation in a plastic electroplating facility. The process is aiming towards recovering up to 95 % of Chromium and Copper and 50% of Nickel, while preserving 65% of fresh water. Implement smart sensor technology for online monitoring, real time process adaptation and deep learning, with customizable intelligent industrial process software module based on an agnostic protocol connectivity cloud infrastructure.

Keywords: membrane technology,reverse electrodialysis,zero liquid discharge,circular economy