Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Genetics and Physiology of Growth and Size Determination (VitruVius)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2023-12-31
Duration (months): 84.0
Total project cost (EUR): 2499144.0
EU funding (EUR): 2499144.0
Participants: 4
Project status: SIGNED

Body size is an intrinsic property of living organisms that is intimately linked to the developmental program to produce fit individuals with proper proportions. Final size is the result of both genetic determinants and sophisticated mechanisms adapting size to available resources. Classical regeneration and transplantation experiments have established that different body parts grow according to autonomous programs, challenging the concept of systemic and harmonious growth. Therefore, coordination mechanisms must ensure that all parts have reached appropriate final size before animals stop growing. The main objective of this program is to tackle the mechanisms ensuring growth coordination and size determination. To tackle these questions, we propose to bring together physiology, genetics, advanced imaging and modelling approaches in an unprecedented integrated project. We will develop these approaches on the Drosophila model where we gained expertise, and will develop the vertebrate model Ambystoma mexicanum (axolotl) well adapted for limb growth and regeneration studies. Three major aims will be addressed: 1- We will explore the mechanisms coupling the developmental clock with organ growth. 2- We will dissect the mechanisms allowing inter-organ growth coordination both in response to abnormal growth (injury/neoplasm) and in the course of normal development (control of developmental instability). 3- We will use our knowledge acquired on insect models to develop Ambystoma mexicanum (axolotl) as a vertebrate model for organ growth coordination. We believe this project brings together novel and complementary expertise that will contribute to broader understanding of the fascinating question of body growth and final size assessment.

Keywords: growth control,developmental timing,insulin,igf signaling,ecdysone signaling
TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease (CENTRE-PD)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,United Kingdom,Luxembourg
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1062500.0
EU funding (EUR): 1062500.0
Participants: 3
Project status: CLOSED

Unlike other EU member states, Luxembourg lacks a tradition for translation of fundamental research into clinical practice, which hampers health innovation and its adoption in cutting-edge medicine. During the last years, the Luxembourg Government made substantial efforts to position biomedicine as a key innovation driver. This highly successful biomedical initiative placed fundamental research on Parkinson’s disease (PD) in Luxembourg on an internationally competitive level, however, to realise the economic and health benefits for the population, closing the gap between basic science and clinical application is now a crucial challenge. CENTRE-PD aims at TWINNING the Universities of Oxford and Tübingen, two worldwide leading centres for PD, with the University of Luxembourg (UL) to establish a comprehensive clinical PD centre in Luxembourg. CENTRE-PD will build human and institutional capacity for an excellent centre for diagnosis and treatment of PD in Luxembourg on the one hand and will ensure sustainability and viability of the centre on the other hand. We expect to reach key deliverables in three areas: (i) building of new infrastructures at UL (including a prospective PD patient cohort and at-risk cohort, a brain bank, neuro-imaging and stem-cell platforms, a neuro-stimulation centre and gait laboratory), (ii) launching of joint research initiatives (harmonised clinical datasets and neuropathological validation, joint biomarker studies for early diagnosis and stratification of PD, compound screening campaings on patient-based cellular models, and joint studies on neuro-modulation), and (iii) engaging key stakeholders through clinical and public outreach programmes, training of clinical researchers and basic scientists, partnerships with industry and initiatives for patient involvement. The external excellent competence provided through TWINNING will strengthen the potential for future collaborations nationally and beyond borders, boosting research excellence.

Keywords: parkinson s disease,cohort,clinical,treatment,diagnosis,oxford,t bingen
Visualising how proteins fold DNA into topologically associating domains in single human cells (ChromaSTORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

How can phenotypic variations emerge from cells that carry the same genetic information? It is one of today’s great challenges to understand how genetic information is modulated inside the cell. Over the last decade, insight from genome-wide proximity-based ligation approaches revealed that the genome is organised in a hierarchical manner with the help of structuring proteins, and that this spatial organisation regulates the core functions of the genome, such as transcription, replication and repair. In this context, topologically associating domains (TADs) were identified as fundamental and functional building blocks of chromatin organisation above the nucleosome level. Despite its vital importance, our current understanding of the spatial organisation of TADs remains largely enigmatic. With the advent of super-resolution microscopy, tools are now available for studying genomic structures and their functional dynamics in situ at a resolution of 10 nm which corresponds to the size of a few nucleosomes. The goal of this project is to reveal the principles of TAD organisation in human cells. To achieve this, I will employ a multidisciplinary imaging-based approach. I will simultaneously visualise the DNA backbone of TADs and architectural proteins involved in TAD structure applying 3D super-resolution microscopy. I will focus on the key TAD organisers CTCF and Cohesin, as well as on Mediator and Condensin II. Additionally, I will directly study their individual structuring function for TADs by their acute depletion. Integrating these data with quantitative measurements of absolute protein copy numbers, I will derive a data-driven model of inner TAD organisation in cells. These studies will provide the first 3D description of this fundamental chromatin super-structure and will further our understanding of genome architecture which is a prerequisite for understanding genome function.

Keywords: topologically associating domains tads,structuring proteins,single molecule localization microscopy,quantitative model
Innovative Wireless Power Devices Using micro-Thermoelectric Generators arrays (WiPTherm)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,France,France,Portugal,Portugal
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-11-01
End date: 2023-06-30
Duration (months): 44.0
Total project cost (EUR): 2315892.5
EU funding (EUR): 2315892.5
Participants: 6
Project status: SIGNED

Micro and Nanosatellites (often referred to as CubeSats) are revolutionizing the paradigm of engineering and space exploration in the last years, in several areas such as weather information and climatic research, multimedia communications, telephone and television, data distribution, transportation and logistics, navigation, safety, security, and rescue. The field of CubeSat is being pointed out as one of the emergent technological markets and it is expected to reach $6.35 billion by 2021, with a CAGR growth of 37.91% in the 2017-2021 period. With advances in CubeSat technologies, the energy demand in this market segment has also increased dramatically, requiring larger deployable solar arrays, lower power electronics, efficient energy storage systems and further energy transfer/harvesting systems. The WiPTherm project will design, implement and pilot an innovative Wireless Energy Transfer (WET) system, able to wirelessly recharge the energy storage components used in CubeSat technologies. The WiPTherm technology consists of a pioneering, clean, easy and cheap solution for energy transfer. The energy harvesting system comprises dozens of microarrays of 2D thermoelectric generators, resulting in a photo-thermoelectric plasmonic (HPTP) system that has the ability to convert photon energy into electrical energy (via thermal gradient). The wireless thermal stimulation will be performed through a large-range pulsed high power laser beam capable of operating at large distances.

Keywords: aerospace,cubesat,thermoelectrics,plasmonic,energy generators,printing technologies,laser,active fibers,optics
Quantum Gas in a Box (QBox)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1943753.0
EU funding (EUR): 1943753.0
Participants: 1
Project status: CLOSED

Ultracold atomic gases offer flexible systems for fundamental studies of both equilibrium and non-equilibrium many-body problems that are relevant across many fields, from condensed matter physics to high-energy physics and astrophysics. In the long run, research on these systems could also lead to practical applications, in the development of novel materials, force sensing, navigation, and quantum information processing. Traditionally, an important difference between "conventional" many-body systems and ultracold gases has been that the former are usually spatially uniform, while the latter were produced in harmonic traps. This difference can often be addressed using the local density approximation (LDA), but for studies of some very important problems it is a serious hindrance. In particular, LDA breaks down close to phase transitions, where the correlation length diverges, and where (due to the “critical slowing down” of the system) some of the most interesting non-equilibrium effects also emerge. Here we propose a comprehensive study of both equilibrium and non-equilibrium many-body phenomena in a homogeneous 39K Bose gas with dynamically tuneable interactions. The use of a homogeneous quantum gas, produced in our newly developed box-like trapping potential (in contrast to the standard setting of a harmonic trap) is a particularly important and unique aspect of this proposal, which will allow for closer connections with both other many-body systems and the theoretical calculations. We will specifically focus on problems in beyond-mean-field physics and on those that cannot be effectively tackled using a harmonically trapped gas. The outstanding problems we will address range from the 50-year-old equilibrium problem of the critical temperature of an interacting homogeneous gas, to the modern topics of quenches and non-equilibrium (Kibble-Zurek and beyond) critical dynamics, to the largely unexplored problem of the unitary Bose gas.

Keywords: strong correlations,beyond mean field,critical behavior,non equilibrium many body dynamics,thermal and quantum quenches,unitary interactions
SBskin. Smart Building skin (SBskin)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of the project SBskin is to assess the feasibility and to develop the business plan related to the commercialization of novel solutions of high architectural and technological quality for the increase of the share of renewable energies and, at the same time, for the improvement of the energy efficiency of the building envelope. The innovation project proposed by SBskin is related to the development of multifunctional translucent components for building façades and roofs, made of highly-insulating glassblocks integrated with 3rd generation semi-transparent PV cells and assembled in precast panels through an innovative dry assembly system. The precast system confers high mechanical resistance and enables to easily install at the same time the components of façade and roof and the PV system, which are directly connected to the load-bearing structure of buildings, reducing time and cost of construction and maintenance. The dry-assembly system makes the dismantling process significantly easier for both panels and subcomponents enabling also their easier recycling/reuse. Moreover, thanks to the features of such innovative PV cells (DSCs), the products proposed by SBskin are also characterized by a wide customizability in terms of colour, transparency and design that can improve their appeal for the BIPV market and their adaptation to the customers’ needs and the contemporary architecture trends. In the context of SBskin project and with the collaboration of other companies, in-depth market studies will be finalized also in relation to the countries where PCT related to SBskin products has been extended. Such studies will include a detailed price analysis and a large user involvement, in order to define the best strategy to launch the products in the target market, starting from possible installations in first pilot sites.

Keywords: bipv,glassblock,smart building envelope,energy efficiency,photovoltaics,innovative products
Testing the locomotor superiority hypothesis for early dinosaurs (DAWNDINOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2498718.76
EU funding (EUR): 2498718.76
Participants: 1
Project status: CLOSED

I seek to unify evolutionary and biomechanical research by achieving a “functional synthesis” in evolution that causally links phenotypes (anatomy) to actual performance. Did early, bipedal dinosaurs evolve advantages in their locomotor performance over other Late Triassic archosaurs (“ruling reptiles”)? This “locomotor superiority” hypothesis was first proposed to explain what made dinosaurs distinct from other Triassic taxa, perhaps aiding their survival into the Jurassic. However, the hypothesis remains untested or unfairly dismissed. I will test this question for the first time, but first I need to develop the best tools to do so. Extant archosaurs (crocodiles and birds) allow us to experimentally measure key factors (3D skeletal motions and limb forces; muscle activations) optimizing performance in walking, running, jumping, standing up, and turning. We will then use biomechanical simulations to estimate performance determinants we cannot measure; e.g. muscle forces/lengths. This will refine our simulations by testing major assumptions and validate them for studying extinct animals, overcoming the obstacle that has long limited researchers to qualitative, subjective morphological inferences of performance. Next, we will use our simulation tools to predict how ten Late Triassic archosaurs may have moved, and to compare how their performance in the five behaviours related to locomotor traits, testing if the results fit expected patterns for “locomotor superiority.” My proposal pushes the frontiers of experimental and computational analysis of movement by combining the best measurements of performance with the best digital tools, to predict how form and function are coordinated to optimize performance. Our rigorous, integrative analyses will revolutionize evolutionary biomechanics, enabling new inquiries into how behaviour relates to underlying traits or even palaeoecology, environments, biogeography, biotic diversity, disparity or other metrics.

Keywords: dinosaur,biomechanics,locomotion,muscle,archosaur,triassic,mesozoic,phylogeny
Supercritical CARbon dioxide/Alternative fluids Blends for Efficiency Upgrade of Solar power plants (SCARABEUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Italy,Italy,Italy,Italy,Switzerland,France,United Kingdom
Call: Developing solutions to reduce the cost and increase performance of renewable technologies (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-04-01
End date: 2024-01-31
Duration (months): 58.0
Total project cost (EUR): 4950266.25
EU funding (EUR): 4950266.25
Participants: 11
Project status: SIGNED

The main objective of the SCARABEUS project is the reduction of the CAPEX and OPEX in concentrated solar power technologies by about 32% and 40% respectively, leading to a final cost of Electricity below 96 €/MWh (lower than 30% of the actual value) through an innovative power cycle based on CO2 blends. This cost reduction will be able to close the gap between CSP and other renewable technologies. This project fits in the call "New cycles and innovative power blocks for CSP plants." as a brand new power cycle concept will be developed. With respect to state-of-the-art sCO2 cycles, the addition of small quantities of selected elements to pure CO2 (i.e. inorganic compounds and fluorocarbons), known as CO2 blending, can increase the CO2 critical point allowing the adoption of condensing cycle even in typical CSP plant locations. Condensing sCO2 cycles have higher thermal-to-electricity conversion efficiency with respect to conventional steam and sCO2 cycles.In addition, higher maximum operating temperature with respect to steam cycles can be adopted with further efficiency increase. The combination of these two aspects enables drastic reductions of the levelised cost of electricity In the project, CO2 blends stable at temperatures up to 700°C (which corresponds to 100°C above current CSP maximum temperatures) and with a pseudocritical temperature of about 50°C will be investigated. A preliminary screen was performed identifying some potential candidates (i.e. TiCl4). Assuming the simple cycle configuration, the TiCl4-blended CO2 outperforms the cycle using pure CO2 by 5% points at 700°C . When using the advanced sCO2 cycle, the efficiency gain is reduced to 2% points, but with significant cost savings. The proposed CO2 blend will be tested in a loop at 300 kWth scale with typical CSP fluids for 300 hours. Long term stability will be measured for 2000 hours and material compatibility assessed through dedicated experiments.

Keywords: concentrated solar power,co2 blends,innovative working fluid,power,cycle
Demand flexibility for cold appliances for supermarkets and retail stores (FLEXCOLD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Netherlands
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The FLEXCOLD project will evaluate the feasibility of developing a Time of Use controller for Commercial Refrigerating Equipment (CRE), such as used in supermarkets and food retail stores. The FLEXCOLD controller enables supermarket and retail store refrigeration equipment to provide electricity demand flexibility, and at the same time reduce it's energy consumption. Small scale (indirect) electricity demand flexibility is desirable as it provides the energy system with flexibility, thus further enabling the growth of the share of renewable electricity production in the EU. The objective of the Phase 1 feasibility study is to elaborate the business plan for the development and EU market introduction of the FLEXCOLD Time of Use controller for commercial refrigeration equipment. Three subobjectives are related to specific items of the initial business plan (section 1.3): - market: development of a business model based on a substantiated and validated value proposition and selected customer segment. Fine tuning of the value proposition with selected representatives from the intended customer segment. - technology: field test assessing the technical feasibility of the concept, planned for June 2015 in a Belgian supermarket of the Colruyt chain. Assess time constants from data measured earlier in 4 Dutch supermarkets. - company: identification and analysis of strength and weaknesses, and of bottlenecks for growth. Financial and contingency planning. Search for business partners for market introduction in other EU countries. Set up relationships with stakeholders..

Keywords: smart grids,demand flexibility,cooling equipment,supermarket