Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Secure Automated Unified Framework for EXchange (SAUFEX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Poland,Netherlands,Lithuania,Finland
Call: Detecting, analysing and countering foreign information manipulation and interference (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2998565.0
EU funding (EUR): 2998565.0
Participants: 6
Project status: SIGNED

Although the European Union's disinformation policy has significantly developed since 2015, Russia’s war in Ukraine has reminded us all of the urgent need to stay ahead of the curve in order to fortify our resilience against the ever-evolving threat of Foreign Information Manipulation and Interference (FIMI). In the last year, Russia’s strategic use of FIMI in its war of aggression against Ukraine has brought an unprecedented response by those defenders who seek to safeguard universal values, democracy, and freedoms by exposing Russia’s efforts to manipulate global discourses. While governance, law, protocols, data exchange, and forensic practices should converge to address FIMI, they currently remain disparate and unaligned. This fragmented approach creates a significant hurdle in the fight against FIMI, hindering the ability of member states to prosecute, ban, attribute, or sanction FIMI actors or campaigns originating from state and non-state actors. To overcome this hurdle there is a need to better synchronise the interventions and harmonise our approach towards FIMI, as proven in the case of cyberattacks. Our consortium, SAUFEX (Secure Automated Unified Framework for Exchange), comprises of concerned stakeholders who possess significant expertise and hands-on experience with the current systems and structures concerning FIMI and are situated in the EU's Eastern regions, where FIMI incidents are frequently observed. We strongly understand the importance of consolidating and utilising available information to establish a collective comprehension of FIMI. To achieve this, our project proposes the creation of a FIMI data-space, which we will herby refer to as a FIMI knowledge database, as well as the establishment of a Resilience Council to act as an intermediary between state and non-state actors, specifically regarding interventions and FIMI attribution.

Keywords: standardisation,framework,resilience,council,intermediary
Harnessing an energy-expending, appetite-suppressing fat-brain axis to unlock novel pharmacotherapies (HEAT-UP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Obesity and cardiometabolic diseases are global crises that threaten to cripple healthcare infrastructures. These disorders originate from an excess calorie burden caused by consuming too much food and expending too little energy. Yet despite recent advances in obesity drugs, weight-lowering pharmacotherapies only reach about half the efficacy of surgical interventions. This difference could be due to existing drugs only acting to reduce food intake and not boost calorie-burning. Therefore, I believe our discovery of a leptin-independent signaling axis between adipose tissue (AT) and the central nervous system (CNS) that both decreases food intake and increases energy expenditure poses a breakthrough in obesity research. We uncovered this axis through receptor profiling and human genetic association studies and engineered a highly selective agonist that significantly decreases bodyweight and improves glucose and lipid homeostasis in obese mice. Our preliminary data have already led to a spinout company. However, the physiological signaling mechanisms of this receptor in AT and the CNS that shape systemic energy balance through peripheral calorie-burning and central control of food intake remain unknown. Thus, in HEAT-UP, we will delineate AT and CNS receptor circuits with single cell resolution and functionally test this signaling in 3D cultures of mouse and human AT. Tissue-specific contributions to whole-body metabolism will be assessed by combining our proprietary, selective agonist with state-of-the-art viral, genetic, and surgical manipulation of the receptor and neuronal wiring in AT and the CNS. Viral and genetic cell-labeling strategies will be used to characterize novel secretory cells that we found in mouse and human AT to contain the ligand for this receptor. Collectively, these studies will provide a comprehensive, physiological overview of a previously unknown fat-brain signaling axis and insight into its potential for counteracting metabolic diseases.

Keywords: brown adipose tissue,adipose thermogenesis,energy expenditure,appetite regulation,obesity,diabetes,g protein coupled receptors
First miniaturized universal gas analyzer for all renewable gases in all their extensive and complex composition at all production and consumption phases including Hydrogen purity for fuel cells (GREENPIX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-02-01
End date: 2025-03-31
Duration (months): 38.0
Total project cost (EUR): 3739250.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Gas chromatographs are powerful sophisticated pieces of equipment but today they are expensive, complex and most of the time are operated in laboratories or expensive shelters. APIX Analytics is willing to revolutionize the gas chromatography market. APIX has the ambition to develop a new generation of gas chromatograph that provides end users with the performance of an analysis laboratory in an embedded portable system. The underlying breakthrough is the invention of a universal detector based on a Nano Electromechanical System (NEMS) called the NGD* (Nano Gravimetric Detector) developed by Apix during the last 8 years (25 patents protect it). The objective of the GREENPIX project is to develop, industrialize and commercialize an ultra-fast and ultra-sensitive gas micro-chromatograph capable of analysing any renewable gas within the same system. To do so, there is today no unique and universal solution.
EARLY NEUTRALIZING ANTIBODIES IN INFANTS LIVING WITH HIV TO ENHANCE THEIR LIFE (ENABLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,Mozambique,Netherlands,Italy,United States,Kenya,South Africa,Cameroon,France
Call: Developing novel, innovative HIV therapeutics for reducing the disease burden of HIV in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 6161157.5
EU funding (EUR): 6161157.5
Participants: 21
Project status: SIGNED

Early ARV treatment in sub-Saharan Africa (SSA) reaches only approximately 50% of infants born with HIV. Mortality in infants in the first 12 months after diagnosis is still over 10% in early treated infants diagnosed at birth, 25% in infants diagnosed with opportunistic infections. According to our experience, the probability of virological control 1 year after diagnosis is only 25 to 35%, even after the rollout of dolutegravir (DTG). As a solution for this problem, we propose the addition of four shots of subcutaneous (SC), long-half-life broadly neutralizing antibodies (bNAbs) at diagnosis, and 3, 6 and 9 months after diagnosis, as an add-on to standard oral ART will provide immediate therapeutic benefit and decrease HIV viral load levels in the most critical period of life of children with HIV, allowing for a decreased risk of co-infections, HIV-encephalopathy and death. We will evaluate for the first time the efficacy of combining two bNAbs (ePGT121v1-LS and VRC07-523-LS, as intensification therapy for ART, to achieve viral suppression within one year after diagnosis in high risk-infants with HIV. The specific aims to achieve this general aim will be: to perform a phase II/III trial with bNAbs, capacity strengthening related with bNAbs in Africa, to characterize biomarkers for anticipating response to bNAbs, to identify the barriers and facilitators of rollout of bNAbs as a treatment, and to liaise with relevant stakeholders The pathway to achieve this aim will be a collaborative framework between a scientific network with partners in several SSA countries, producers of bNAbs, and European and African laboratories. With this approach, the probability of viral suppression 1 year after diagnosis will be increased from 30% to 95% to achieve 2030 UNAIDS 3rd target. This achievement will impact in a reduction of HIV- associated morbidity and mortality in the first year of life and beyond in more than 130 000 infants every year.

Keywords: broadly neutralizing antibodies,hiv,children,infants,anti retroviral treatment,biomarkers
Dual-channel paper-based electroanalytical platform for multiple myeloma care (PADMME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Romania
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 133735.68
EU funding (EUR): 133735.68
Participants: 1
Project status: CLOSED

Multiple myeloma (MM) is an aggressive type of cancer of plasma cells where fast diagnosis and treatment monitoring is vital, especially given the overall low survival rate. Proteasome, a multi-catalytic complex essential in damaged protein degradation, has been recently established as a biomarker for MM, in which elevated levels have been observed in blood plasma of unhealthy individuals, as well as its impaired activity has been target for treatment alongside regular chemotherapy. PADMME addresses increasing contributions on proteasome electrochemical recognition and aims to develop novel interdisciplinary technologies translatable into POCT systems for MM care. For this, we propose the development of sensitive and selective dual-channel platforms comprising conductive polymeric fiber biosensors integrated on paper-based microfluidic supports to simultaneously detect quantity and specific activity of proteasome in blood plasma. Paper supports ensure disposability and ease of commercialization, whilst incorporation of microfluidic paths allows low sample volume requirements and in situ pre-treatment steps. Conductive polymeric fiber scaffolds provide increased signal resolution for the construction of biosensors, necessary for the recognition of low concentrations of the biomarker. Then, investigating proteasome at the dual-channel platform in drug-treated and untreated MM cell lines will demonstrate how changes in quantity and specific activity are specifically linked to the disease dynamics. The last step will comprise validation of the technology for analysis in blood plasma, technology able to improve overall monitoring of MM disease progression and therapeutic efficiency, crucial to overcome delays in treatment due to drug resistance complications. Training through research will allow me to refine my expertise, creativity and innovative potential on smart biosensor technologies translated into point-of-care testing devices for cancer care and drug assessment.

Keywords: proteasome,biosensor,electrochemistry,bioelectrochemistry,biomarker,multiple myeloma,paper,microfluidic
Efficient and rapidly SCAlable EU-wide evidence-driven Pandemic response plans through dynamic Epidemic data assimilation (ESCAPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Belgium,Netherlands,France,Italy,Portugal,United Kingdom,Switzerland
Call: Pandemic preparedness (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2420930.0
EU funding (EUR): 2420929.75
Participants: 8
Project status: SIGNED

Pandemics have the potential to disrupt our daily lives and to affect every part of society. SARS-CoV-2 causing COVID-19 disease painfully showed how responding too late, in a fragmented mannar and/or with too little coordination across different sectors and countries, led to huge human and economic costs. ESCAPE’s main objective is to improve efficiency and scalability of early pandemic response plans by providing evidence-based guidelines, standardised research protocols, retrospective insights, and digital solutions that will support scientists in producing and integrating evidence and inform public health authorities in taking decisions to avert or reduce disease and societal burden. The project will provide knowledge and tools that will enhance Europe’s preparedness for a pandemic of pathogen X. These include a science-based blueprint for faster and better decision-making in managing pandemics, tools and frameworks to improve data availability, collection and sharing, as well as advanced analytics and models to understand and project transmission dynamics of pathogen X under candidate response scenarios. ESCAPE will also identify determinants of success and failure in managing pathogen X based on the SARS-CoV-2 pandemic, helping to develop effective response strategies for future pandemics. In addition, the project will contribute to fostering a multi-stakeholder intelligent community allowing improved knowledge sharing and cooperation between policy-makers, the scientific community, the media and the public, ensuring a much more effective response to future pandemics. In the long-term, by improving pandemic preparedness and the effectiveness of response to a pandemic of pathogen X, the project will contribute to reducing health burden and potential negative societal and economic consequences during pandemics, as well as increase the confidence of policy makers and the public in science-based solutions.

Keywords: pandemic response pathogen x evidence based through data assimilation and mathematical modelling multi stakeholder intelligent community
Beyond the Information Paradigm: from Prediction to Anticipation (BeyondInformation)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Within theoretical neuroscience, many have by now embraced the view of the brain as a prediction machine which updates its predictions in light of incoming information. Yet, these ‘Predictive Processing’ theories (PP) face big conceptual challenges. As I've shown previously, by relying on semantic notions like information, representation, prediction, hypothesis-testing etc., they resist integration within the larger causal-mechanistic framework of which they claim to be a part. The twofold problem is, first, how to make naturalistic sense of semantic content or meaning at the level of individual neurons or neural populations and, second, how the assumed semantic content is supposed to be causally efficacious. Yet, if we can’t understand the neuroscientific data in terms of upstream information, downstream prediction and resulting prediction errors, how, then, should the neuroscientist interpret the bidirectional neural activity? Via 3 complementary research objectives (RO1-03), this project is aimed at providing an alternative explanation for the neuroscientific data which is traditionally framed in terms of information processing and, more recently, information prediction. For RO1, the pivotal move will be to substitute the problematic notion of prediction with an empirically underpinned biological notion of anticipation that does not involve semantic content, and which does fit within the boundaries of the causal-mechanistic framework. With RO2, this notion of anticipation-without-prediction will be applied to the neuroscientific findings the PP theorist explains in terms of prediction. RO3 will be dedicated to further study anticipation-without-prediction at the microbiological level via lab experiment. Overall, the project aims to present an alternative to the computationalist view of the brain, which identifies neural activity with information processing. In this sense, the project has paradigm-shifting potential.

Keywords: brain as information processor,predictive processing,anticipation,embodied cognition,enactivism,neuroscience,cognitive science,microbiology
Support to the Vice-Presidents of the ERC Scientific Council 2024-2025 (ERC VP CSA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Germany,Denmark,Norway
Call: Support to the Vice-Chairs (HORIZON-ERC-2023-VICECHAIRS-IBA, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 750000.0
EU funding (EUR): 750000.0
Participants: 3
Project status: SIGNED

This project provides the necessary support to the Vice-Presidents of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required under the Horizon Europe framework programme. Under the Horizon Europe programme, the European Research Council provides a competitive funding mechanism for investigator-driven frontier research at the European level. One of the key structural components of the ERC is the Scientific Council consisting of 21 eminent researchers and their President, representative of a large range of disciplines and institutional backgrounds. The ERC ScC independently establishes and oversees the ERC's scientific management and the implementation of the Work Programme, including the peer review and the selection of peer reviewers. The project aims to support the ERC Vice-Presidents, who, unlike the ERC President, act on an honorary basis, in the efficient and timely achievement of the ScC’s objectives in 2024 and 2025. The diverse responsibilities of the three Vice-Presidents of the ERC include the achievement of efficient and effective functioning of the ScC, its integrated operation together with the ERC Executive Agency (ERCEA), and effective interfacing with the scientific community, other funding agencies and the political institutions of the European Union. The project provides administrative and research support ranging from secretarial tasks to assistance in developing policy papers related to the work of the Vice-Presidents of the ERC for a period of two years. The project objective is to provide local administrative, operational, and advisory support for the three ERC Vice-Presidents. The project contains a single work package which encompassed all the various tasks associated with this objective.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liaison with the erc executive agency
Smart Integration of Process Systems Engineering & Machine Learning for Improved Process Safety in Process Industries (PROSAFE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Spain,United Kingdom,United States,Norway,Türkiye
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2028-05-31
Duration (months): 53.0
Total project cost (EUR): 2881679.66
EU funding (EUR): 2773692.0
Participants: 10
Project status: SIGNED

PROSAFE proposes a novel doctoral training program in the multidisciplinary field combining machine learning, artificial intelligence, and process systems engineering with domain knowledge of process industry and process safety. PROSAFE will pioneer new foundations by integrating Quantitative Risk Assessment, Process Systems Engineering (PSE) with interpretable machine learning (ML) and artificial intelligence (AI) disciplines as targeted breakthroughs to achieve the objectives. To this end, PROSAFE will develop new synergistic tools and train skilled professionals to address this very important societal, economic, and environmental challenge of safe and sustainable process industries. PROSAFE research objectives are: 1: Harmonize robust QRA methods and implementation strategies for effective and improved risk assessment and process safety 2: Develop AI and ML (interpretable ML) models using domain knowledge for efficient, safe, and reliable operations 3: Develop synergistic integration of model-based with data-based methods for improved process safety operation and monitoring 4: Demonstration and validation of PROSAFE novel concepts and methods on industrial relevant case studies for safer operation PROSAFE's major training objectives are: 1: Training of doctoral candidates (DCs) through individual projects combining multidisciplinary competences in the areas of AI, ML, and PSE within the domain of process safety 2: Establish and pilot the concept of a truly interdisciplinary European multicenter training program in AI/ML, QRA, and PSE within the domain of safety in process industries through relevant network-wide events, courses, workshops, and on-site industry training that complements training in soft skills for effective communication and entrepreneurship. Through this research and training program, PROSAFE will contribute to realizing the promising potential of the new artificial intelligence paradigm with a particular focus on process safety in process industries.

Keywords: process safety,quantitative risk assessment,process systems engineering,machine learning,machine learning,high hazard process industries,lng processing,renewable hydrogen,urea production