Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDING AT THE SYNAPSE (C.NAPSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2492750.0
EU funding (EUR): 2492750.0
Participants: 3
Project status: CLOSED

Synaptic scaffolding molecules control the localization and the abundance of neurotransmitter receptors at the synapse, a key parameter to shape synaptic transfer function. Most characterized synaptic scaffolds are intracellular, yet a growing number of secreted proteins appear to organize the synapse from the outside of the cell. We recently demonstrated in C. elegans that an evolutionarily conserved protein secreted by motoneurons specifies the excitatory versus inhibitory identity of the postsynaptic domains at neuromuscular synapses. We propose to use this system as a genetically tractable paradigm to perform a comprehensive characterization of this unforeseen synaptic organization. Specifically, this project will pursue 4 complementary aims: 1) Identify and characterize a comprehensive set of genes that organize and control the formation and maintenance of these scaffolds through a series of genetic screens based on the direct visualization of fluorescent acetylcholine and GABA receptors in living animals. 2) Solve the spatial synaptic organization of these scaffolds at a nanoscale resolution using super-resolutive and correlative light and electron microscopy, and analyze their dynamic behavior in vivo by implementing Single Particle Tracking imaging in living worms. 3) Decipher the role of the synaptomatrix in the organization of synaptic extracellular scaffolds and evaluate its functional contribution at the physiological and molecular levels using a candidate gene strategy and innovative imaging. 4) Analyze the formation and decline of these scaffolds at the lifetime scale and evaluate the role of synaptic activity and aging in these processes by taking advantage of the possibility to follow identified synapses over the entire life of C. elegans. Using powerful genetics in combination with cutting-edge in vivo imaging and electrophysiology, we anticipate to identify new genes and new mechanisms at work to regulate normal and pathological synaptic function.

Keywords: synapse,synaptic scaffold,acetylcholine receptor,gaba receptor,extracellular matrix,c elegans,genetic screen,super resolutive microscopy,clem
Experimental and computational screening of Oxides for Thermochemical Energy Storage (OxiTES) (OXITES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Renewable and sustainable energy systems of the future are only possible in combination with storage technologies for bridging the gap between production and consumption of energy. The use of solar energy is inherently limited by the intermittency of solar light which requires robust and efficient solutions for energy storage. One of the attractive storage options for large-scale solar systems is ThermoChemical Energy Storage (TCES) based on the use of reversible chemical reactions. TCES combines high heat storage density with unlimited storage duration, endowing the energy storage efficiency and flexibility. Currently, the number of materials studied for TCES at high temperatures remains very limited, hindering further development of thermochemical systems. The project is aimed at the search for promising TCES materials among oxides of earth-abundant metals by combining experimental and theoretical studies. First, a longlist of promising oxide candidates (< 200) will be generated based on structural databases. Then, the experimental screening will be done to outline conditions for their hydration and carbonation reactivity and measurement of relevant parameters such as sorption capacity and heat. The theoretical study bridging DFT calculations with the experimental data by means of machine learning will highlight the structure-property relationship for the broad set of oxides. Finally, several most promising materials with high storage density will be tested in a prototype of chemical heat pump operating at T = 300-600oC. As a result, a library of promising oxides for high-temperature H2O and CO2 sorption will be generated and theoretical guidelines for future target-based development of oxide systems for this purpose will be delivered. This project realized within DLR (Germany) in cooperation with Delft University of Technology (Netherlands) will bring the TCES closer to market scale. The idea is in line with the current EU policy towards renewable energy.

Keywords: energy storage,metal oxides,hydration,carbonation,chemical thermodynamics
Correlated Electron-Nuclear Dynamics: A novel mixed quantum-semiclassical approach (CoEND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The experienced researcher, Dr. Ali Abedi, and the host supervisor, Prof. Angel Rubio, aim at developing a new predictive and practical approach that overcomes the difficulties that current methods have to treat the correlated electron-nuclear dynamics in systems such as light-harvesting complexes. The proposed project starts with the fundamental method development based on the “exact factorization framework” recently introduced by the researcher, goes through a systematic performance test to reach the desired accuracy/efficiency trade-off, and will be implemented in a computational platform to be applied to study large systems such as artificial light-harvesting complexes.

Keywords: coupled electron nuclear dynamics,beyond born oppenheimer approximation,time dependent density functional theory,semiclassical dynamics,light harvesting complexes
Development and apparatus implementing a method for rapidly and already ends freezing and defrosting fish with the use of sound waves and aerosol humidification for high quality fish. (FRISH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

European self-sufficiency rate for fish is just 44%, this means that more than half of the fish has to be imported into the EU. Fish is being transported hundred or even thousand kilometres before arriving to the European market. The imported fish has to be frozen to travel the long distances. Ungermann, an innovative SME and technology leader in refrigeration technology, has developed FRISH based on previous research projects and vast experience in food preservation and refrigeration technology. The novelty of FRISH is the use of aerosol as air humidification in combination with ultrasonic waves to freeze and/or defrost fish and to reduce the energy input in the process improving the quality of the fish, and reducing the wastes (less damaged/decayed fish loss). While air humidification in the form of an aerosol of microscopic water droplets will allow a better heat transfer, thus a faster process and preventing product drying-out; ultrasonic waves will increase heat and mass transfer, thus reducing process time. FRISH technology, aims to minimize the costs and at the same time, to increase quality of fish, to reduce the quantity of damaged/decayed fish caused by freezer burn, microbial contamination or low quality defrosting methods (up to 35%), to create a safe and microorganism-free system, to preserve the fish properties: taste, proteins, colour, consistency, texture and surface, to reduce time (up to 80%), to save energy (up to 70%), among other advantages. FRISH will tackle two main social, environmental and economic concerns on the current world in the area of fish: food waste, and quality in food.

Keywords: fish quality,freezing,thawing,energy savings,food security,avoidance of food waste
Predicting global vulnerability of forests to drought using plant functional trait evolution (Plant-FATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

The earth is projected to experience higher climate variability in future, with increasing frequency and intensity of extreme events such as droughts and wildfires. Drought is a severe threat to world’s forests, and incidents of drought-induced forest die-back are already being reported. The resistance of the world’s forests to drought will be key to maintaining crucial ecosystem services, such as sequestering carbon and maintaining biodiversity. To understand what plant traits are responsible for drought-resistance, we aim to push the envelope of contemporary eco-evolutionary dynamic vegetation modelling. Accounting for trade-offs in growth via acquisition of resources and resistance to drought-induced mortality, we will allow plant traits to evolve under realistic drought regimes. We will calibrate and test our model using data on plant traits and long-term demography available from two tropical forest sites – a wet site from Costa Rica, and a seasonally dry site from southern India. We will then parametrize our model at a wider scale, using available data on traits and environmental fluxes from sites across the globe in different biomes. Bringing together expertise from plant physiology, evolutionary dynamics, and high-performance computing, our approach will advance our abilities to predict evolutionarily emergent plant strategies, plant productivity, and ecosystem services under current climatic conditions, and identify species and regions that are likely to be vulnerable to future changes in climate. Our models and methods could potentially be adopted for similar analyses in the agriculture sector. We will communicate our results to policymakers and the public via an interactive web-based dashboard. IIASA will provide the researcher with the perfect platform for research training, and for a dialogue with policymakers and other stakeholders to prepare for mitigating and adapting to climate change.

Keywords: plant functional traits,evolutionary dynamics
Algebraic Foundations of Supersymmetric Quantum Field Theory (SCFTAlg)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2026-02-28
Duration (months): 66.0
Total project cost (EUR): 1963921.0
EU funding (EUR): 1963921.0
Participants: 1
Project status: SIGNED

A critical challenge of the current era in theoretical and mathematical physics is to understand and solve strongly coupled quantum field theories. Meeting this challenge will necessitate a significant reformulation of the edifice of quantum field theory and will surely require dramatic mathematical breakthroughs. To this end, a productive and promising strategy is to focus on the intricate algebraic structure of observables in quantum field theories, and in particular in those theories that are fixed points of the renormalization group, namely conformal field theories. From this point of view, supersymmetric quantum field theories are ideal theoretical laboratories; they enjoy special structure properties that not only improve their tractability but position them centrally in several areas of contemporary mathematics. Additionally, the landscape of known superconformal field theories is much richer than its non-supersymmetric counterpart and includes many models of interest due to their connections with string theory, holography, and particle physics. In recent years it has been recognized that the combination of (extended) supersymmetry and conformal symmetry guarantees the existence of several remarkable cohomological reductions of the full operator algebras of these theories. This is a proposal to establish a world-leading research team to develop these "superconformal operator algebras" into a coherent framework that can be used as a non-perturbative backbone for the analysis of such models. The team will include a diverse array of researchers with expertise in conformal field theory, supersymmetric localization, topological field theory, geometric representation theory, and vertex algebras. Our framework will be used to constrain, organize, and classify the landscape of SCFTs, as well as to solve for supersymmetric observables in theories of interest. It will also serve as a rigorous mathematical entry point for the study of these theories more generally.

Keywords: conformal field theory,strong coupling,supersymmetry,duality,vertex operator algebra,deformation quantization,conformal bootstrap,topological field theory,supersymmetric localization,class s
Advanced chemicals production from biogenic CO2 emissions for circular bio-based industries (CO2SMOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Spain,Italy,Spain,Belgium,Norway,Greece,Belgium,Netherlands,Netherlands
Call: Bio-based industries leading the way in turning carbon dioxide emissions into chemicals (H2020-FNR-2020-2, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 6918240.0
EU funding (EUR): 6918240.0
Participants: 16
Project status: SIGNED

Biorefinery industries are in a unique position to lead the way in turning CO2 emissions into added-value chemicals due to their intrinsic keenness towards innovation and their potential to transform their biogenic CO2 waste streams into bio-based chemicals that can be integrated within their own processes in a circular way. CO2SMOS aims to develop a platform of technologies to transform CO2 emissions produced by bio-based industries into a set a of high added-value chemicals with direct use as intermediates for bio-based products. The result is a toolbox combining intensified chemical conversions (electrocatalytic and membrane reactors) and innovative biotechnological solutions based on gas/liquid combined fermentation processes and organic/green-catalysts reaction processes, which allow versatile production, depending on the available resources and the targeted value chains, of seven different bio-based chemicals. These molecules will be validated as renewable CO2-based commodities for the formulation of high-performance biopolymers and renewable chemicals. The five breakthrough technologies involved in CO2SMOS will ensure low energy use (< 50 kWh/kg of CO2-based chemical), low production cost (< 1.75 €/kg), high product yield (up to 68% the ideal yield) and an outstanding GHG-abatement potential (avoiding of up to 10 additional kg of CO2 per each kg used as feedstock), which will contribute to the sustainability and cost competitiveness of the integrated conversion processes. Integration of CO2SMOS concept in existing and emerging biorefineries (supported by Scale Up and Replication plans) will contribute to expand the business portfolio and strengthen the economic base of the sector. A campaign to assess social acceptance of CO2SMOS solutions and to promote awareness of their environmental, social and economic benefits is also foreseen. The consortium counts on academic, RTO and industrial partners with two major actors in the biorefinery sector.

Keywords: bio based industry,gas fermentation,co electrocatalysis,3 bdo,dicarboxilic acid,cyclic carbonates
Regulating RAS Activity to Target RAS-Driven Cancers (RASATaC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

More than a quarter of all cancers are driven by mutations in the RAS family of genes. Considering the key role of these oncogenes, and despite intensive effort, no effective anti-RAS strategies have successfully made it to the clinic. In our ERC-CoG project, we found that a class of scaffold proteins, expressed in cancer, bind to active/mutated forms of RAS proteins to moderate RAS signalling. Accordingly, we find that loss of one of the scaffolding protein isoforms in RAS-mutant cancers triggers cytotoxic signalling, leading to cell death. As such, drugging this scaffold protein could not only i) represent a completely innovative approach to target RAS-driven cancers that exploits the oncogene’s function, but also ii) deliver the first truly effective cancer treatment for patients that do not respond to current standards of care. In this ERC-PoC, we aim to prove that therapeutic targeting of the scaffold protein is effective in vivo, and to explore the commercial avenues to exploit this finding.

Keywords: cancer,oncogene,therapeutic targeting
Homomorphic Encryption Applications and Technology (HEAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Belgium,France,United Kingdom,Luxembourg,United Kingdom
Call: Cybersecurity, Trustworthy ICT (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-03-31
Duration (months): 39.0
Total project cost (EUR): 4165726.25
EU funding (EUR): 4165726.25
Participants: 9
Project status: CLOSED

Homomorphic cryptography offers the tantalizing goal of being able to process sensitive information in encrypted form, without needing to compromise on the privacy and security of the citizens and organizations that provide the input data. The HEAT proposal brings together Europe's leading researchers on homomorphic cryptography (KU LEUVEN, UNIVBRIS and UL), with the leading expertise on lattice based cryptanalysis (UPMC), and three industrial partners with existing interests in the field (CRX, NXP and Thales UK). The goal of HEAT is to produce a step change in the efficiency and applicability of this technology. The proposal leverages existing ground breaking research in Europe, and links this with three industrially contributed case studies as a way of grounding the research in practical issues. The case studies proposed by the industrial partners consist of smart grid, statistical analysis to automate the detection of organized crime and shared satellite infrastructure applications. The project will focus on Somewhat Homomorphic Encryption (SHE). Not only is this a stepping stone on the way to Fully Homomorphic Encryption, the partners also believe that SHE is a useful cryptographic tool in its own right. We aim to demonstrate this applicability via our three case studies. Motivated by the three case studies the project will examine new design and implementation techniques for homomorphic cryptography, as well as a thorough security analysis. The security analysis is likely to have wider applicability due to the linkage with post-quantum cryptographic systems based on lattices. The proposed outputs of HEAT are an open source software library to support applications that wish to use homomorphic cryptography. The results of the HEAT project will be highly beneficial to European industry and academic research since they allow for using homomorphic cryptography to be used by a much wider variety of end developers.

Keywords: homomorphic encryption