Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Public Participation in Developing a Common Framework for Assessment and Management of Sustainable Innovation (CASI)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: A more dynamic governance of the science and society relationship
Action type: Coordination and support actions
Countries involved: Bulgaria,United Kingdom,Denmark,Finland,Germany,Slovenia,Poland,Italy,Portugal,Austria,United Kingdom,Belgium,Portugal,Czechia
Call:  (FP7-SCIENCE-IN-SOCIETY-2013-1, 2013)
Start date: 2014-01-01
End date: 2017-06-30
Duration (months): 42.0
Total project cost (EUR): 4378995.34
EU funding (EUR): 3897381.0
Participants: 21
Project status: CLOSED

The proposal responds to the Horizon 2020 challenge called "Climate action, resource efficiency and raw materials”. In addition, it addresses the second specific challenge of the Mobilising and Mutual Learning Action Plans (MMLAP) topics, listed in the Science in Society call for proposals of the Capacities Work Programme 2013, namely "Assessment of sustainable innovation". The project’s main objective will be to develop a methodological framework for assessing sustainable innovation and managing multi-disciplinary solutions through public engagement in the RTDI system by ensuring the commitment of a broad spectrum of societal stakeholders into its implementation, including industry, policy-makers, research organisations and academia, civil society organisations and the general public. In achievement to the overall objective of the proposed action, the specific objectives include the development of: - a working definition of sustainable innovation, building on common definitions, academic literature as well as expert advice internal and external to the project consortium; - ways to include general public concerns in assessing the social impact of these innovations on society in consultation workshops. Issues such as participation in the development of innovation, inclusiveness, ethics, gender and open access will be considered in these sessions; - a common understanding of best practices in sustainable innovation management; - a framework for assessment and management of sustainable innovations; - specific policy recommendations on how to improve innovation management and how sustainability considerations can be incorporated into it based on the findings of the assessment framework and public consultations. CASI mobilises 19 partners from 12 EU Member States. Through a network of country correspondents CASI will cover the whole of Europe. The work is structured in 11 work packages, and the mandatory work packages as outlined in the call are included.

Keywords: sustainable innovation assessment,social innovation,technological innovation,public participation,mobilisation and mutual learning,climate action,resource efficiency and raw materials
Investigation of Novel biomarkers and Definition of the role of the microbiome In Graves’ Orbitopathy (INDIGO). (INDIGO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Italy,Germany,Italy,United Kingdom
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2014-05-01
End date: 2018-04-30
Duration (months): 48.0
Total project cost (EUR): 1192798.54
EU funding (EUR): 1192798.54
Participants: 5
Project status: CLOSED

Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term impairment of quality of life. To improve the outcomes of people with GO and thus reduce long-term illness and cost to society, research is needed to address the identification of risk factors, develop a better understanding of the pathophysiology of the disease, devise approaches for early diagnosis during the pre-clinical stage of the disease, and create novel and safe interventions. INDIGO will refine and optimise animal and in vitro models of Graves’ disease and GO, which are urgently required to facilitate the study of the pathogenesis of GO. INDIGO will address the identification of risk factors for the initiation and perpetuation of autoimmunity that causes disease, using the latest generation technologies to study variations in the microbiome in Graves and GO patients and controls. The interaction of the gut derived antigens, from micro-organisms and nutrients on the autoimmune response in both the animal model by probiotic and “contra-biotic” intervention. State of the art technology will be used to search for biomarkers that will identify patients that will progress to GO, during the preclinical phase of the disease when intervention is most likely to be successful. The successful completion of the project will be ensured by a partnership involving 2 SMEs, 3 academic institutions and the European Group on Graves' Orbitopathy, each contributing complementary expertise and technology, the project will involve 5 secondments and 3 recruitments that will facilitate the exchange of knowledge and training.

Keywords: graves' disease,graves' orbitopathy,autoimmunity,biomarkers,microbiome,proteomics,mirna,in vitro models,murine models,diagnostics,probiotics.
Research on extraction and formulation intensification processes for natural actives of wine (WINESENSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Portugal,Netherlands
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 950421.54
EU funding (EUR): 950421.54
Participants: 4
Project status: CLOSED

The Wine industry is an important sector for the EU economy and the development of new wine-related products could lead to sustainable growth and development of the sector. WineSense proposes to improve the extraction process to catch most of the active parts of the polyphenols (present in grapes), to define a suitable formulation for pharmaceutical applications, food, and cosmetics additives based on Solvent Free Microwave Extraction,Microwave Assisted Extraction (MAE), and emulsion-Template techniques combining high pressure and antisolvent effects. WineSense combines the efforts of industry and academia in order to optimize the polyphenol extraction and formulation techniques, intensifying the process and reducing the loss in antioxidant capacity. Only thus we can synthesize an actual active compound that is suitable for health, food and wellness applications, in response to the models and innovative approaches of natural products and the challenges of the European Knowledge-Based-Bioeconomy. This project sets the framework for the transfer of knowledge and long-term collaboration between 3 industrial and 1 academic partners in the field of extraction and formulation of most of the active part of polyphenols (soluble and non-soluble). ToK and collaboration will be fostered through mutual exchange of researchers: 11 researchers from academia and industry will be involved in 88 months of secondments; 2 of them will be experienced researchers recruited to complement the consortium capabilities (36 months of recruitment). Additionally, this project aims at creating strong impact in the involved partners by fostering long lasting networks around its driving technologies such us bio & nanotechnology (EU KETs) and also exploring its potencial applications helping mantein Europe at the vanguard of knowledge technologies. Above all, the combination of partners expertise and capacities will support the success of the project.
Extracellular Vesicles and exosomes from adult stem cells in the regeneration of organ injury (EVESTEMINJURY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,United Kingdom,Netherlands,Spain
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2014-02-01
End date: 2018-01-31
Duration (months): 48.0
Total project cost (EUR): 1249747.23
EU funding (EUR): 1249747.23
Participants: 5
Project status: CLOSED

Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages. The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs can modulate the phenotype of target cells is an emerging paradigm in the intercellular communication. The extracellular RNAs are thus now considered as paracrine/endocrine signals. EVs contain diverse species of RNAs (mRNA, miRNAs and long non-coding RNAs) reflecting the functional state of the cell of origin. Recent studies on adult stem cell-induced tissue regeneration pointed out paracrine/endocrine mechanisms rather than permanent engraftment and trans-differentiation of stem cells. Therefore, the paracrine/endocrine hypothesis has changed the perspective of the therapeutic use of stem cells in regenerative medicine. Additionally, several studies indicate that EVs play a relevant role as mediators of stem cell induced regeneration by reprogramming injured cells. Within this project, we will explore the different necessary aspects in order to get a more profound knowledge on EVs, on their mechanisms of action in tissue injury, and on the definition of the most promising “active biological ingredients” of their content to further promote EV as new potential therapeutic strategies in the field of regenerative medicine. Also, within the EVStemInjury project, two different approaches of EV production will be explored: Biological and Synthetic, showing the different potential design strategies and to assess their efficiency. Finally, in order to explore the renoprotective effect of EVs, developed within the project, ranging from toxic, ischemic and reperfusion models, we will use a large number of experimental in vitro as in vivo models of acute kidney injury.

Keywords: kidney disease,extracellular vesicles,exosomes,mrna,renal transplantation,liposomes,nanotechnology.
Stakeholders Acting Together On the ethical impact assessment of Research and Innovation (SATORI)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: A more dynamic governance of the science and society relationship
Action type: Coordination and support actions
Countries involved: Netherlands,United Kingdom,Denmark,Serbia,France,Finland,Italy,Spain,Slovenia,France,Sweden,Netherlands,United Kingdom,Poland,Austria
Call:  (FP7-SCIENCE-IN-SOCIETY-2013-1, 2013)
Start date: 2014-01-01
End date: 2017-09-30
Duration (months): 45.0
Total project cost (EUR): 4664371.46
EU funding (EUR): 3662800.35
Participants: 20
Project status: CLOSED

SATORI is a 45-month project, comprising 17 partners from 13 countries, including an intergovernmental organisation, the aim of which is to improve respect of ethics principles and laws in research and innovation, and to make sure that they are adequately adapted to the evolution of technologies and societal concerns. The partners will develop an ethics assessment framework based on thorough analysis, commonly accepted ethical principles, participatory processes and engagement with stakeholders, including the public, in Europe and beyond. The project comprises 12 work packages, starting with a systematized inventory of current practices and principles in ethics assessment. WP2 reviews existing projects and identifies stakeholders. WP3 investigates the impact of globalization and the extent to which research is conducted outside Europe to profit from more flexible frameworks. In WP4, the partners outline an ethical assessment framework and create a roadmap for a fully developed framework. WP5 concerns the cost-effectiveness and risk-benefit of ethics assessment. WP6 address other impacts and gathers stakeholder views on those impacts. The partners will study the prospects for standardizing the framework in WP7. In WP8, the partners will develop a strategy for sustainability of the SATORI network. In WP9, which runs throughout the project, the partners will monitor policy developments and other initiatives at the EU, MS and local levels which merit ethical assessment and alert our network accordingly. The partners have devised a multi-pronged communications strategy to interact with stakeholders in WP10. WP11 is project management. In WP12, the partners have created an independent evaluation of and reflection upon the project, which will enable any necessary remedial actions to enhance it. SATORI’s experienced partners bring complementary perspectives and knowledge from academia, industry, research institutes, science academies, journalism and other sectors.

Keywords: ethics,responsible research and innovation,research ethics,ethics assessment,ethical principles,risk-benefit,participatory methods,standardisation,globalisation
Mid-High Frequency Modelling of Vehicle Noise and Vibration (MHIVEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Germany,Germany
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 1944975.26
EU funding (EUR): 1944975.26
Participants: 5
Project status: CLOSED

The control (and avoidance) of vehicle noise and vibration (NV) provides a crucial competitive advantage for car manufacturers due to the drive for lower noise pollution levels and enhanced driving comfort. NV issues can seriously detract from the reputation of a vehicle with a knock-on detrimental effect for the entire brand. As the automotive industry moves towards virtual prototyping, the simulation and modelling of vehicle NV is becoming increasingly important. Providing accurate numerical predictions in this area is an extremely challenging task. A detailed analysis of the structural vibrations on very fine scales is required, and small parameter changes can lead to large shifts in the frequency response function for a given vehicle. The wide range of materials and intricate couplings between different components provide enormous challenges for the NV simulation of a full vehicle, especially in the range of frequencies above 500Hz. Robust and efficient NV modelling techniques are, however, urgently needed by vehicle manufacturers for cutting costs by removing the need to develop expensive physical prototypes. The range of existing techniques addressing NV issues as part of the Computer Aided Engineering (CAE) toolkit is not adequate. The methods are not robust for frequencies over 500Hz and do not naturally fit into the simulation environment of CAE, where structural data are provided via mesh specifications. Only recently have these problems been overcome through new solution techniques developed and tested by the academic members of this project. Together with two specialized SMEs and the car manufacturer Jaguar Land Rover, this interdisciplinary and inter-sectoral consortium will develop the first black-box and mesh based tool for the vibro-acoustic analysis of a full vehicle body. This will catapult noise and vibration analysis from the research and development stage to a fast and reliable everyday tool for the engineering practitioner.

Keywords: computer aided engineering,noise,vibration and harshness,structural mechanics & dynamics,automotive engineering,numerical analysis,mid-to-high frequency waves,statistical energy analysis
Water and Soil Clean-up from Mixed Contaminants (WASCLEAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovakia,Greece,United Kingdom,Kazakhstan,United Kingdom
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 2407958.0
EU funding (EUR): 2407958.0
Participants: 8
Project status: CLOSED

This project aims to develop novel materials and technologies for remediation of contaminated soils and groudwaters from xenobiotics (e.g. man-made) contaminants, via a programme of knowledge exchange and scientific work actions between 8 partner organisations (6 from three EU countries and 2 from an ICPC country). Chemical and biological approaches will be combined to develop novel technologies for removal of toxic metals/metalloids and recalcitrant organic contaminants from contaminated soil and groundwaters. A range of methods, based on iron chemistry and biogeochemistry, bioremediation and electrochemical oxidation will be employed at laboratory and pilot/field scale, to produce integrated clean-up solutions for problem contaminated sites and contaminants. The project brings together a multidisciplinary consortium of specialists from different areas of contaminated land management, environmental (geo)chemistry, nanotechnology, (geo)microbiology and physical, analytical, synthetic, polymer and surface chemistry, working with a common aim of developing new and efficient methods of contaminant removal from soils, and groundwaters.

Keywords: soil,remediation,cleanup,xenobiotics,pops,bioremediation,iron nanoparticles,advanced oxidation,ultrasounds,sorption,toxic metals,pesticides,azo-dyes.
Converged Optical-Mobile Access Networks with Dynamic and Efficient Resource allocation (COMANDER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece,Spain,Germany,Netherlands
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 2326807.12
EU funding (EUR): 2326807.12
Participants: 4
Project status: CLOSED

Total 108 6 114 7 42 4 0 0 0 0 COMANDER aims at bringing together experts from the industry and academia with the long-term goal of delivering a state of the art, cutting-edge and cost-efficient approach to the problem of Next-Generation access Networks (NGN) design. The design of NGN has since long dictated the necessity to merge the currently distinct optical and wireless infrastructures into an amalgamated network capable of offering the best part of both worlds: the stability and ultra-high speeds of optical fiber networks with the agility and flexibility of wireless networks. To achieve this goal COMANDER employs a novel design that builds upon the Radio-over-Fiber paradigm, and proposes all the necessary solutions to overcome the existing limitations. Moreover COMANDER goes beyond the architectural convergence by addressing for the first time the matter of NGN intelligence that will unleash the full capabilities of the unified Fiber-Wireless architecture. The scale and diversity of the NGN vision calls for the cooperation of many interdisciplinary experts from the fields of optical communications, wireless engineering, protocol design, network coding and simulation that up to now operated independently. COMANDER achieves these objectives via the fruitful collaboration of four partners, two from academia, i.e., Aristotle University of Thessaloniki (AUTH) and Technical University Berlin (TUB), and two SMEs, i.e., PhoeniX Software B.V. (PHX) and iQuadrat (IQU). As a whole, the partners have consolidated and complementary expertise in the engineering, design, analysis, simulation and experimentation that are demanded to fulfill the project’s goals.

Keywords: optical wireless networks,radio-over-fiber networks,passive optical networks,60ghz wireless,photonic integrated circuits,medium-transparent mac protocols,network coding over rof
Targeting challenges of active ageing: innovative integrated strategies for the healing of age-related hearing loss (TARGEAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Italy,Czechia,France,Austria
Call:  (FP7-PEOPLE-2013-IAPP, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 1341405.17
EU funding (EUR): 1341405.17
Participants: 5
Project status: CLOSED

Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. The TARGEAR project is constituted by experienced research groups in complementary fields ranging from the molecular to the clinical aspects of age-related hearing loss. The general objective is to develop a collaborative strategy between public research centres and private companies, based in transfer of knowledge, to design and implement preclinical studies for presbyacusis. A second general objective is to contribute to the formation of early-stage researchers in the experimental design, transfer and translation of knowledge in the field of hearing loss. It is essential for Europe future aged population to have well-trained people available to understand hearing loss from a general perspective. According to this, the foreseen secondments and training activities will involve a total of 15 experienced and early-stage researchers. In the end, TARGEAR project will develop a stronger biomedical research in hearing loss for a better future for the deaf people.

Keywords: presbyacusis,age-related hearing loss,cochlear implants,kinases,deafness animal models,clinical application,translational research,transfer knowledge,training,secondment