Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IST-BRIDGE: International postdoctoral program (IST-BRIDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 9195000.0
EU funding (EUR): 4597500.0
Participants: 1
Project status: SIGNED

The IST-BRIDGE program will host 60 fellows across the life sciences, mathematics and computer science, and the physical sciences recruited over 5 globally advertised calls. BRIDGE fellows will receive a 2 year contract, with an additional (fellow option) 6 month secondment phase. IST-BRIDGE will be hosted by IST Austria and embedded into the BRIDGE network, where BRIDGE stands for Basic Research Institutions Delivering Graduate Education, bringing together five of the 2019 Nature Index Top 10 research institutions worldwide. This network will help the program to achieve visibility and provide secondment options on a global scale, thus benefiting the ERA. IST-BRIDGE will provide researchers in basic science a unique opportunity to bridge their training and/or experience gap. Fellows will be enrolled in a Career Development Program, which is structured in four profiled tracks, a combination of desired career goals and concrete professional options. It will provide experienced researchers with the necessary information, tools, and opportunities to make informed career decisions. Fellows have the option to consolidate skills acquired through the Career Development Program through a broad secondment scheme consisting of 1) global academic secondments at BRIDGE network partners, 2) intersectoral secondments, and 3) intrasectoral placements within IST Austria. Fellows will be provided with the framework (flexible agreements, existing partner networks, IST Austria Alumni Initiative) and experienced support services (Tech Transfer Office, HR, Grant Office) to facilitate fellow-driven (i.e. bottom-up), dynamic interaction with actors from other fields and sectors and to develop sustainable partnerships and their own scientific and professional network.

Keywords: career tracks,global network,knowledge transfer,basic science
Interaction and Kinetics of Oxidative Biomass Degrading Enzymes Resolved by High-Resolution Techniques (OXIDISE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1929319.0
EU funding (EUR): 1929319.0
Participants: 1
Project status: CLOSED

Current processes for lignocellulose deconstruction are unspecific and produce some constituents in poor quality. Specific biocatalysts could achieve optimal segregation together with minimal damage to cellulose and lignin and provide high-quality feedstocks for industry. Naturally occurring fungal oxidoreductases perform this task, but their characterisation – and hence their optimisation for industrial application – is difficult because of the experimental challenges. The mission of OXIDISE to develop appropriate methods to characterise lignocellulose degrading oxidoreductases, i.e. elucidate their conversions rates and to resolve their distribution and interaction in vicinity of their polymeric substrates. High-resolution techniques will be adapted to specifically detect fungal oxidoreductases like lytic polysaccharide monooxygenase, cellobiose dehydrogenase, laccase, lignin peroxidase, or members of the GMC oxidoreductase superfamily. These enzymes are all involved in the oxidative attack of recalcitrant biopolymers and are present in over 90% of fungal genomes. To overcome problems of current assaying techniques such as their low spatial and temporal resolution, OXIDISE will develop and apply techniques based on microelectrodes, scanning electron microscopy, surface plasmon resonance and fluorescence microscopy thereby pursuing three objectives: 1) study the interaction of all major oxidoreductases secreted by fungi in regard to electron transfer, regeneration of redox species and substrate cascading; 2) resolve the distribution of secreted oxidoreductases on cellulosic and lignocellulosic substrates at high resolution; 3) transfer the developed techniques to natural lignocellulose samples with growing fungal hyphae and study the secreted oxidoreductase activities. OXIDISE strives to establish new techniques to elucidate the kinetics and interactions of oxidoreductases – a long neglected enzyme class for lignocellulose depolymerisation.

Keywords: biosensors,extracellular electron transfer,wood degrading fungi,lignocellulose depolymerisation,oxidoreductases
First nanotechnology for the electronic packaging industry based on a room-temperature welding process (NanoWelds)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The electronic packaging industry, with revenues estimated at €1.2 billion for 2020, is currently stuck mostly due to the fact that the triad performance, form-factor and cost has reached its limit. Key sectors such as the semiconductor and e-mobility industry are claiming for the development and implementation of new integration technologies able to fulfil their current needs in line with decreasing device size, cost-effectiveness, and efficient packaging. At NanoWired GmbH, a German company recently founded, we are working in finishing the development of NanoWelds, a disruptive 3D-integration technique based on a nanotechnology. By means of a two-steps process, and thanks to the full-controlled coating of the surfaces to be assembled with nanowires, NanoWelds is able to bond different types of surfaces at room temperature and without using any additives. The NanoWelds technology represents the first economic-viable process based on a nanotechnology generating reproducible nanowires in any type of substrate meeting at the same time the homogeneity and quality requirements of the industry. With NanoWelds we are bringing the electronic packaging industry one step beyond by overcoming current limitations on soldering or gluing techniques, which require high temperature and, often, noble or toxic metals, thus making the process economically viable for industrial production. In addition, thanks to the automation of the whole process, we are facilitating the uptake of nanotechnology by this industry, thus enabling the next generation of consumer electronics, sensors, accumulators, and batteries among others. The market launch of NanoWelds represents the beginning of our sales activity planned for the second half of 2020. By the end of 2022, three years after market uptake, we expect to obtain an accumulated revenue of €14.5 million and have created up to 30 new positions in our company.

Keywords: nanotechnology,welding at room temperature,nanowires,semiconductor industry,electronic packaging industry,3d integration technique
Non-invasive smart wearable solution for continuous monitoring of physiological parameters and biomarkers for chronic patients with cardiac and respiratory diseases from the neonate to the elderly (ONALABS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Spain
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Onalabs Healthcare was born as an ambitious project, technical and emotional focused in premature births where the patient is affected with Congenital Heart Disease (CHD). These patients need 24hour Intensive care monitoring for a period of at least 10 days where 25% of their total blood is extracted to measure 4 biomarkers (Lactate, pH, CO2 and Glucose). This generates pain and a high risk of vain damage as well as potential death due to infections. Moreover, Heart and lung system problems are the first and fourth cause of death, respectively in Occidental territories, with more than 20 million deaths recorded in 2012. The solution that is offered by Onalabs with its product ‘Cardiopatch’ that addresses a potential market of 872M users. Our product does not rely on the extraction of blood to measure the 4 key parameters. We measure indirectly through a proven system of sweat analysis. This will allow us to also access the sport market and an additional 350M users in the sector of this that we target. Targetting health care and sport, with a novel disruptive sensor we expect to drive a new market providing solutions providing high impact for society whilst growing to generate profits of 3.4M euros and employ 40 people by 2022

Keywords: biosensors,biomarkers,cardiac diseases,respiratory diseases,smart wearable
Biological relevance of the multiple infection unit as a novel target for antiviral development (CM_GF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-10-31
Duration (months): 33.0
Total project cost (EUR): 226010.88
EU funding (EUR): 226010.88
Participants: 2
Project status: CLOSED

The last decade of research in enteric virus infection produced a body of compelling evidences that challenged the paradigm of the single infection unit, where a single virus is able to elicit infection of a target cell. Instead, observational studies of infection in vivo and in vitro suggest that enteric viruses travel in groups: in vesicles with inverted phosphatidylserine topology or at the surface of commensal bacteria. It has been proposed that both strategies increase locally the viral multiplicity of infection, thus favoring viral complementation of defective genomes. There is a lack of knowledge on the biological relevance of the so-called multiple infection unit (MIU) as it has not been mechanistically studied in physiologically relevant model of the GI tract. In addition, the MIU is a strategy employed by all the enteric viruses so far tested, therefore it might represent a valuable target for the design of broad spectrum therapeutics. The central hypothesis of this project is that targeting MIU will inhibit enteric virus infection ex vivo and in vivo. My model of enteric virus is human norovirus (HNoV) for its clinical relevance and for its well described interaction with commensal bacteria. In work package (WP)1, to gain insight on the biological relevance of MIU in ex vivo physiologically relevant models, I will test the hypothesis that MIU increases HNoV infection in human intestinal enteroids. In aim 2, I will develop an in vitro screening platform by pulldown assay with His-tagged HNoV virus-like particles to i) screen for small molecules inhibitors of the infection and ii) identify bacterial species that are bound to HNoV in stool derived from healthy volunteer and diseased patients (i.e. inflammatory bowel disease, Crohn) . In aim 3, in order to provide evidence that targeting MIU blocks viral infection, I will test the efficacy of the small molecules identified in aim 2 in the ex-vivo model established in aim 1 and/or in-vivo, in a murine model.

Keywords: trans kingdom interactions,enteric viruses,glycans,antivirals
THE REAL ESTATE FINANCE-URBAN CLIMATE RISK NEXUS: A COMPARATIVE ANALYSIS OF MIAMI, ROTTERDAM, AND SINGAPORE (REALCLI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-14
End date: 2021-01-13
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

The connections between real estate governance and urban climate risk management represent a critical missing link between urban research, policy-making, and practice. Real estate climate risk management practices have important consequences for the welfare and prosperity of at-risk cities, yet climate risk management cultures and practices vary greatly between cities. These highly particular variables shape an increasingly globalized real estate industry’s exposure to climate risks in any given context and project. This dynamic and differentiated interaction of institutions, imperatives, and interests that govern real estate climate risk – both across the global real estate industry and within at-risk cities -- may be termed the real estate finance-urban climate risk nexus. The proposed project advances the theoretical and empirical understanding of the real estate finance-urban climate risk nexus (i) across the contemporary landscape of real estate finance institutions and (ii) within major coastal property (re)development projects in three case cities, in order to (iii) synthesise a critical and comparative understanding of how understandings of climate risk reshape the global real estate industry finance, and restructure the property markets of vulnerable coastal cities.

Keywords: real estate,disaster planning,climate adaptation
Invest for Excellence in Regional Sustainability (INVEST4EXCELLENCE)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Bulgaria,Finland,Greece,Slovakia,Netherlands
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 1902100.0
EU funding (EUR): 1902100.0
Participants: 5
Project status: SIGNED

INVEST4EXCELLENCE aims at developing an integrated and long-term joint strategy on research and innovation in line with the education strategies from the INVEST EU University Alliance. The thematic focus of the INVEST Alliance is in Sustainable development as one of the most important global challenges. INVEST4EXCELLENCE will create the background for the development and implementation of research and innovation ideas through developing of Model for institutional transformation at research and innovation dimension; developing of European Innovation Ecosystem for Academia-Business & Society; developing of Capacity Building Tools; and implementing and promoting the I-EDUC8EU tool. Involving and engaging the main actors in the regions – civil society, local citizens, local enterprises, public authorities, education institutions (including an academic sector) and NGOs, will be the basic precondition for conducting the research and bringing the innovation into regions. Considering the importance of such stakeholders´ engagement, dedicated involvement tool describing the process and methods of thematic dialogue and promotion of innovations will be developed. This will lead to reinforcement of human resources in the research and innovation of the INVEST Alliance contributing to achieving the knowledge-based civic society, engaged in creation and benefitting of the high quality research and innovation outputs. Project comes with several key enabling educational and digital technologies that can optimize all research and innovation aspects promoted by the INVEST Alliance. Project will influence the interactions between institutional adaptation and the transformation of research and innovation systems by analysing change and adjustment within the whole alliance. INVEST4EXCELLENCE brings together a large European educational community that will actively cooperate and maximize the learning impact of the project.

Keywords: higher education,regional sustainability,regional development,european universities
Rwenzori Ice Dynamics and Environmental Changes (RIDEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-07
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

At the border between Uganda and the D.R. of Congo, the Rwenzoris form a remote and high-altitude mountain range stretching through the East African Rift System. With heights of 4-5 km, they include Africa's third highest peak (Mt. Stanley, 5109 m) as well as some of the last African glaciers. The combined area of the Rwenzori glaciers declined by more than 75% during the 20th century, and halved between 1987 and 2006. This extreme mass loss may have strong implications for the local hydrology, ecosystems and communities, and recent estimates suggest that the glaciers will disappear in the next decade(s). This trend correlates well with similarly dramatic glacier retreats on Mt Kilimandjaro (Tanzania) and Mt Kenya (Kenya) during the same period, and is attributed to increased air temperature or reduced humidity/cloud cover. Despite recent work on the evolution of glacier extent in the last decades, the measured glacier retreat, as well as the interpretation of the driving climatic factors responsible since the 1980’s, remain controversial and are limited to available data. In order to better understand the dynamics of this recession, we will survey the current state of the two largest Rwenzori glaciers, Stanley and Speke glaciers, using a panel of remote sensing, geophysical and geochemical methods. These include, first, surveying of glacier extents over the last decades using satellite imagery, mapping of the current glacier extent and main features using differential GPS, and assessing the glacier thicknesses using ice-penetrating radar. These three steps will allow for further ice flow modeling. Second, the use of weather station data in the glacier vicinity as well as ice/water sampling for geochemical analysis will allow investigating the glacier sensitivity to the changing climate and its (palaeo-)environmental potential. These results will be compiled with a view to provide a first estimate of modern, past and future ice budgets in the area of interest.

Keywords: tropical glaciers,glacier recession,climate change,glaciology,east african highlands
Type I bursts in 3D (Burst3D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

On Earth, nuclear explosions take place in controlled environments or use small amounts of fuel. Despite that, they generate spectacular amounts of energy. When nuclear reactions ignite on a neutron star, the whole surface can burn, resulting in extremely bright X-ray flashes that outshine all the other emission. These flashes are known as type I bursts. Their emission encodes information about the neutron star mass and radius and this makes them ideal probes to explore such stars' properties. Much effort has been invested to describe nuclear explosions, both on Earth and in space, but the modelling of the type I bursts entails extra difficulties. In particular, simulating deflagrating flames in the extreme conditions of neutron stars has proven particularly challenging. Nonetheless, in the last several years I have been able to produce the first ab initio 2D simulations of type I bursts where the deflagration takes place inside a burning hurricane that expands to engulf the whole surface of the star. However, 2D simulations have inherent limitations. With this project I intend to model the nuclear explosions during the bursts combining detailed microphysics with a magnetohydrodynamical description set for the first time in a 3D spherical geometry to be able to capture the combination of all the relevant effects. Understanding all the different facets of the bursts and their physical ingredients, I will produce unprecedented simulations which I will couple to a ray tracing code that takes into account the general relativistic effects of the star's gravity and rotation on the emitted photons. I will be able to produce extremely accurate synthetic lightcurves to confront with the observations in order to extract the information about the neutron star contained in the X-ray emission. Once the parameters of the bursters are known, these can be used to constrain the yet unknown behavior of matter in the core of neutron stars.

Keywords: thermonuclear type i burst,x ray burst,neutron stars