Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting Innovation in Organic FRUIT production through strong knowledge NETworks (BIOFRUITNET)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Italy,Spain,Germany,Sweden,Sweden,Switzerland,Poland,Latvia,France,Czechia,Netherlands,Denmark,Denmark
Call: Thematic networks compiling knowledge ready for practice (H2020-RUR-2019-1, 2019)
Start date: 2019-11-01
End date: 2023-04-30
Duration (months): 42.0
Total project cost (EUR): 1999302.5
EU funding (EUR): 1999302.5
Participants: 16
Project status: SIGNED

The EU is the leading region for the production of organic fruits, with a rapidly expanding production and a demand for organic products which grows every year. However, at the same time, the amount and value of organic imports from outside the EU is increasing. For organic fruit farmers in the EU this poses a challenge to succeed in an increasingly competitive market. In addition, organic fruit growing is a very demanding farming activity. This is because, the sector faces specific problems that cannot be solved using conventional approaches based on the use of synthetics substances. As organic fruit growers cannot rely on synthetic inputs, many of them have, on a local level, developed competitive strategies to improve plant health. Moreover, there is considerable research on improving organic fruit growing systems. The problem, however, is that this knowledge is not easily accessible to farmers all over Europe and remains either locally known or only available in the scientific sphere. The sector is in need of a network focused on organic fruit production that bridges the gap between science and practice and makes locally found solutions available to other fruit growers in Europe. Therefore, the specific objectives of BioFruitNet are: 1) Collect and synthesize existing knowledge ready for practise, 2) Create a stable European innovation network, 3) Strengthen established networks, 4) Widely distribute solutions, 5) Extend the Organic Farm Knowledge Platform. To achieve these objectives, we will first carry a thorough mapping exercise to find relevant networks at national level in partner countries and beyond (WP1). Then, compile all existing practical and scientific knowledge relevant to organic fruit farmers (WP2) and select the best practices (WP3). We will then focus on adapting and translating all best practices in an easy-to-understand format like practice abstracts (WP4) and disseminate the information through high impact channels (WP5).

Keywords: organic fruit growing,knowledge transfer,supporting networks,sharing best practices
CLEANING SOLUTION FOR POST-FIRE REMEDIATION - 100% ELIMINATION OF PAH (PAHremov)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PER (Professional Engineering Restoration) is an Italian SME that performs recovery and renovation services after catastrophic events. In particular, much care must be placed after fires in order to eliminate dangerous Polycyclic Aromatic Hydrocarbons (PAH). With, PAHremov, targets the upgrade and industrialization of an innovative solution, composed by the integration off PER's x1 cleaning solution and a lipopectic biosurfactant, being able to reach 100% complete removal and ulterior total biodegradation of PAH in a secure and sustainable way, which will takes place much faster than using the current alternatives based on organic solutions and biosurfactants notably improving their PAH removal capacity and taking just 6-8 hours for total removal and biodegradation. In addition, the final solution is biodegradable and smaller disposal volumes are produced. These facts mean an improved site recovery, less waste (almost 98 % less weight) and an improved impact for the environment. PAHremov will directly reduce the costs of these decontamination activities by about 70%, allowing PER to intensify notably its international presence and increase its revenues. The payback for the estimated investment will be reached during the third year of commercialization of the PAHremov's based new service.

Keywords: polycyclic aromatic hydrocarbon,fire,decontamination,pah removal,site recovery,biodegradation,chemical surfactants,biosurfactants,dangerous waste
A EUropean study on effectiveness and sustainability of current Cardiac Rehabilitation programmes in the Elderly (EU-CaRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Germany,Switzerland,France,Netherlands,Netherlands,Denmark
Call: Comparing the effectiveness of existing healthcare interventions in the elderly (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 6434243.5
EU funding (EUR): 5593048.5
Participants: 11
Project status: CLOSED

Cardiovascular diseases (CVD) cause over 4 million deaths in Europe each year and mass disability: within the coming decades the disability-adjusted life years (DALYs) estimate is expected to rise from a loss of 85 million DALYs in 1990 to a loss of 150 million DALYs globally in 2020. Moreover, patient numbers are expected to rise rapidly in the next decades, due to an ageing society such that the burden of CVD for both patients and the healthcare sector will further rise. Cardiac rehabilitation (CR) is recognised as an effective approach for risk reduction and long term care of patients facing cardiovascular diseases (CVD). However, knowledge on CR in the elderly is limited, while tailoring of CR programmes to the elderly is needed. The reasons for this relates to the following aspects: 1) the elderly account for the majority of cardiac admissions and procedures, yet studies on cardiac rehabilitation have traditionally focused on younger patients , 2) many older patients who would derive benefit from CR interventions, do not participate, 3) there is a lack of commitment and adherence to CR within in the older population with only a minority completing the full programme and 4) a cardiovascular event in elderly patients could be a trigger for disability and dependence. Knowledge is lacking on effective approaches for this specific target group and moreover the specific challenges related to the target group must be addressed. With the ambition to achieve a breakthrough in cardiac care, the main objective of EU-CaRE is thus to obtain the evidence base to improve, tailor and optimise CR programmes regarding sustainable effectiveness, cost-effectiveness and participation level in the elderly. This is achieved through an comparative effectiveness analysis of current conventional cardiac rehabilitation programmes (CR), as well as new innovative mobile telemonitoring guided cardiac rehabilitation (mCR). As such, the project addresses the objectives of call PHC 17.

Keywords: cardiac rehabilitation,elderly,sustainable effectiveness,cost effectiveness,participation level,compliance
Trans-Atlantic Modelling and Simulation For Cyber-Physical Systems (TAMS4CPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Coordination and support actions
Countries involved: Germany,United Kingdom,United Kingdom
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 399650.0
EU funding (EUR): 399649.75
Participants: 4
Project status: CLOSED

Smart systems, in which sophisticated software/hardware is embedded in physical systems are part of everyday life. From simple products with embedded decision making software to massive systems in which hundreds of systems, each with hundreds or thousands of embedded processors, interoperate, the growth of cyber-physical systems (CPS) is likely to accelerate. For Europe to benefit from this expansion, while avoiding the pitfalls that such complexity creates, there must be advances in the modelling and simulation (M&S) of CPS. Collaborative research with the US will be an opportunity to advance European M&S capabilities for CPS. The overall aim of TAMS4CPS is to lay the foundations for concrete EU-US collaboration in modelling and simulation for cyber-physical systems. To achieve this, Loughborough and Newcastle Universities (M&S) will work with Steinbeis Innovation (road mapping) and leading researchers in the field at top US universities to create: - A strategic research and collaboration agenda, endorsed by researchers in EU and US - A set of test cases for model developers to perform collaborative evaluation - A state of the art web-based report to act as a baseline for collaborative research Taking a consultative approach, we will engage industry and academic researchers and M&S users in workshops and web-based meetings to prioritise M&S research challenges and to create a constituency of future collaboration partners for pre-competitive research in the Artemis themes, of: - Architectures principles and models for safe secure Cyber-Physical Systems - Systems design, modelling and virtual engineering for Cyber-Physical Systems - Autonomous adaptive and cooperative of Cyber-Physical Systems - Computing platforms and energy management for Cyber-Physical Systems To which is added the exploitation and enabling theme of: - Integration of socio/legal/governance models within modelling frameworks Thus, this project directly addresses European priorities in CPS.

Keywords: modelling and simulation
A Multi-Theory Multi-Method Approach for Preventing and Reducing Radicalization leading to Violence (MULTIPREV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2499900.0
EU funding (EUR): 2499900.0
Participants: 1
Project status: SIGNED

The UN has recently proclaimed 2020-2030 the Decade of Action and its top priority is fighting violent extremism. This call is grounded in the insufficient progress achieved despite the vast efforts from Governments and scholars to tackle this issue. The main shortcomings of previous approaches are (1) theoretical (poor consensus about the nature and causes), (2) empirical (infrequent access to populations of interest), and (3) methodological (research designs that do not allow to test for causality, no comparative studies, over-reliance on qualitative data). I am going to introduce and test empirically the first comprehensive multi-theoretical framework for the study of radicalization leading to violence and deradicalization by understanding its nature to develop intervention programs. In part one (WP1) I will develop a multi-theory model for the nature and mechanisms underlying radicalization leading to violence and deradicalization. In WP2 I will develop an innovative methodology to assess these processes by a platform for data collection including dynamic and interactive measures of radicalization and deradicalization in large samples in five continents. WP3 will examine the mechanisms underlying radicalization outside and inside prisons in 10 nations (Spain, Iraq, Indonesia, Sri-Lanka, Colombia, Morocco, Palestine, Egypt, Tunisia, Jordan) through interviews, combined with online cross-sectional and longitudinal experiments to allow the inference of causality. WP4 will focus on the development of evidence-based programs designed to prevent radicalization in prisons and to conduct de-radicalization with incarcerated violent extremist offenders. The contributions of this framework are twofold: a) advancing the scientific understanding of violent extremism by collecting unique empirical data from samples of violent extremist offenders collected worldwide, and b) providing novel evidence-based strategies and tools for predicting and preventing violent extremism.

Keywords: terrorism,radicalization,deradicalization
Smart Cholesterol-Mopping Polymer Nanoparticles in Niemann-Pick Disease Type C (NanoMop)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 145845.6
EU funding (EUR): 145845.6
Participants: 1
Project status: CLOSED

Niemann-Pick Disease Type C (NPC), also known as “childhood Alzheimer’s”, is a rare genetic disorder caused by the accumulation of cholesterol particularly in the brain with subsequent cognitive and mobility decline. In the EU NPC has an incidence of 1 per 100,000 people. Most cases are detected during childhood and progress to cause life-threatening complications by the second or third decade of life. Cyclodextrins (CDs), a family of naturally occurring sugars, have recently gained considerable attention as a potential therapeutic intervention in the treatment of the disease because of their capacity to sequester cholesterol. Although promising, the current treatment of NPC based on a chemical modification of bCD suffers from poor pharmacokinetics and bioavailability in the brain. In this project I propose a new interdisciplinary approach in which bCDs will be embedded into a novel class of smart polymer nanoparticles (NanoMops) that could overcome these limitations. The project addresses an important question that needs to be answered urgently and its successful completion will contribute to the treatment of the neglected disease in line with the Horizon2020 health goal of providing better and more effective therapies. My specific skillset in chemical modification of CDs puts me in a unique position to successfully carry out this project. This interdisciplinary proposal is designed to provide me with advanced training in macromolecular chemistry and in a range of cutting-edge biological techniques. The fellowship will significantly diversify my competences and broaden my profile – professionally and personally - enabling me to pursue a career as an internationally recognised independent researcher. The project will also create new important international and inter-sectoral partnerships with excellent academic and industrial players while reaching out to charity organisations, raising awareness and networking researchers and key stakeholders in the area of NPC

Keywords: cyclodextrins,polymers,nanoparticles,niemann pick disease type c
Motivic Cohomology of Schemes (MoCoS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1635650.0
EU funding (EUR): 1635650.0
Participants: 1
Project status: SIGNED

The project belongs to the field of arithmetic algebraic geometry and is centred around algebraic K-theory, motivic cohomology, and topological cyclic homology. The overall goal is to develop a general theory of motivic cohomology for arbitrary schemes, extending the existing theory of Bloch, Levine, Suslin, Voevodsky, and others in the special case of smooth algebraic varieties. This will describe non-connective algebraic K-theory via an Atiyah--Hirzebruch spectral sequence. The project relies on very recent breakthroughs in algebraic K-theory and topological cyclic homology. In the case of singular algebraic varieties, our goal will be to develop a theory of motivic cohomology which both satisfies singular analogous of the Beilinson--Lichtenbaum conjectures and is also compatible with the trace maps to negative cyclic and topological cyclic homology. Its properties will refine those of K-theory in the presence of singularities; for example, we will study a motivic refinement of Weibel's vanishing conjecture and a theory of ``infinitesimal motivic cohomology'' satisfying cdh descent. In the case of regular arithmetic schemes we will propose a new approach to the theory of p-adic motivic cohomology, based on topological cyclic homology and syntomic cohomology, which works in much greater generality than previous approaches. Perfectoid techniques will play an important role and we will establish the p-adic Beilinson--Lichtenbaum and Bloch--Kato conjectures.

Keywords: motivic cohomology,k theory,topological cyclic homology,syntomic cohomology,p adic schemes
Controlling Influenza A Virus Liquid Organelles (LOFlu)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2870250.0
EU funding (EUR): 2870250.0
Participants: 1
Project status: SIGNED

The world health organization monitors viral infections worldwide with the aim to coordinate strategies to control viral outbreaks. The on-demand development of vaccines or antibody treatment does not confer a first line of defense against unpredictable infections caused by new viruses in humans such as pandemic influenza, corona or Ebola viruses, and new approaches are needed. We propose to investigate the fundamental basis of novel host-pathogen interactions in influenza A virus (IAV) infection that may define new antiviral strategies. We discovered that the important pathogen IAV induces the intracellular assembly of viral inclusions that behave like liquid organelles. IAV inclusions serve as assembly sites for the IAV segmented genome, a key step in the viral lifecycle. We now find that the maintenance of the liquid character of IAV inclusions is essential for viral replication. As we identified some of the host and viral components of IAV inclusions, we now have the tools to interrogate how specific interactions and cellular processes result in phase-separated compartments. We aim to learn how the function of IAV inclusions is related to their material state and investigate the potential of imposing phase transitions in an organism to limit IAV infection. Phase separation provides a novel conceptual framework to tackle how viruses exploit cells to organize viral reactions in space and in time. It also provides alternative principles for exploring aspects of the IAV lifecycle not yet fully understood, including how influenza epidemic and pandemic genomes assemble. Taken together, we propose a new, integrated approach for studying phase separated phenomena, from the molecular to the organismal level, that will bring a deeper understanding and control to viral infections. Our work will also be of relevance to other fields of biomedicine, including in the science of soft matter that is involved in neurodegenerative diseases and some cancers.

Keywords: influenza a virus,virology,cell biology,membraneless organelles,cellular structure,viral assembly
Barley Biofarmed Growth Factors to Make Cell Cultured Meat an Affordable Reality (CCMeat)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Iceland
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 3809356.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

ORF Genetics is a female-lead plant biotechnology company biofarming protein in barley for use in medical research, stem cell technology and skincare. Since 2001, we have produced over 50 proteins, specializing in human growth factors (GFs) which regulate the growth and development of cells. Our main focus has been on GFs for skincare use and now with our team of over 80 qualified scientists, researchers, marketers and more, we are aiming at a larger market, the cell-cultured meat (CCM) industry. The CCMeat project removes the biggest hurdle CCM producers are facing to bring their alternative meat products to market. With innovations in our technology we will produce affordable, endotoxin-free growth factors designed specifically for CCM: the MESOkine™ line (patent to be filed in June 2020). This will be done by scaling cultivation from our 2000m2 state-of-the-art geothermally powered greenhouse in Iceland to in-field cultivation sites. We will also introduce a protein processing technology (patent to be filed in July 2020) that will substantially decrease production costs and lead to greater GF yields. By 2030, our MESOkine™ line will drop GF prices from 3000€/kg of cultured meat to approximately 0.7€/kg meat at scales necessary to produce over 7 million tonnes of meat. We are already providing samples to CCM customers and expect to reach a 40% market share within 5 years with our strong first mover advantage. MESOkine™ sales are expected to rise exponentially and reach profitability of €19 million by 2026. As the demand for meat continues to grow, this innovation will have a profound impact on our planet, enabling CCM to avert many of the negative consequences of conventional meat production. This includes reducing greenhouse gases by more than 250 million tonnes of CO2-eq emissions, deforestation by producing 7-52 times as much meat with one hectare of land, and antibiotic resistance by sparing over 1000 tonnes of livestock antibiotic use.

Keywords: cell cultured meat,affordable synthetic meat,growth factors,biofarming,barley