Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creating materials banks from digital urban mining (SUM4Re)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Norway,France,Finland,Germany,Estonia,Belgium,Switzerland
Call: Intelligent data acquisition and analysis of materials and products in existing built works (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01-TWO-STAGE, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 7205130.49
EU funding (EUR): 5999897.22
Participants: 17
Project status: SIGNED

SUM4Re proposes a comprehensive approach to creating materials banks from the built environment by combining urban mining and technologies for automated on-site data acquisition and building materials identification and asset components. The project aims to achieve nine objectives, including developing a traceability system for building materials, developing a holistic methodological framework for assessing circular use of construction products, and developing on-site and off-site smart digital solutions to identify construction entities and analyse their properties. The methodology of SUM4Re is based on a systemic approach that encompasses three main activities: identification, analysis, and contribution to circularity. The project aims to develop software tools and databases based on robust identification assisted by AI and other digital techniques, supported by blockchain solutions, and consider circular economy processes such as Reduce, Reuse, Repair, Recycle, and Renovate. SUM4Re will improve the BIM standard to support current circular (C-BIM) challenges, following open standards and ensuring interoperability with commercial databases. SUM4Re proposes three demonstration pilots linked to construction projects to validate the methodology and a strategy for skill development to upskill the workforce in the construction sector and facilitate the uptake of the solutions developed. Overall, SUM4Re aims to support the transition towards circular construction practices and reduce the amount of construction and demolition waste sent to landfills. The relevance of the project lies in the need to address the increasing generation of construction and demolition waste, which is the largest waste stream in the EU, as well as the problems associated with CO2 emissions and climate change. The project emphasizes the use of new techniques and technologies to rapidly identify materials and support circular construction practices.

Keywords: secondary materials remote sensing ai bim standardization digital building logbooks material passports demolition plan renovation plan 5re process
SMART community-led transition for Europe's Rural Areas (SMART ERA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Innovation actions
Countries involved: Italy,Slovenia,Finland,Austria,Belgium,Spain,Bosnia and Herzegovina,Bulgaria,Poland,Switzerland
Call: Smart solutions for smart rural communities: empowering rural communities and smart villages to innovate for societal change (HORIZON-CL6-2022-COMMUNITIES-02-two-stage, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7013862.5
EU funding (EUR): 6592887.5
Participants: 27
Project status: SIGNED

Depopulation, mostly characterized by emigration of young people, is occurring in rural areas all over Europe. This has brought to an ageing phenomenon, as well as the emergence of several structural problems such as fewer job opportunities, degradation of infrastructures and a decreasing offer of services of general interest. However, the revolution in digitalisation with an increase of remote and location-free work opportunities is offering the chance to redirect some rural migration flows back. Interventions are thus needed to take up this opportunity and build on trends such as multi-local living to promote new greener, smaller, sustainable and innovative growth models. It is there where SMART ERA intervenes. The project will foster resilience in rural areas, by upgrading and co-designing, co-developing and co-validating with local communities a set of smart solutions, integrated within Smart Innovation Packages (SIPs) able to tackle pressing socio-economic and environmental challenges and promote a community-led transition pathway that will empower rural people to act for change. SMART ERA’s main ambitions are: a) building the first large-scale European-wide solution for systematic rural data screening and smartness analysis; b) using co-design methods and techniques to involve residents and stakeholders in the design and validation of SIPs, as well as in the collection of old and creation of new data sources; c) proposing a unified Smartness/Digital Maturity assessment method; d) providing unique and timely evidence-based and performance-focused recommendations to upgrade the new local, national and European policy instruments and enhance their efficiency and efficacy in supporting smart villages across the EU; e) fostering cooperation among pilot regions, as well as among the four EU macro-regional strategies and improve their rural communities’ ability to address socio-economic and environmental challenges.

Keywords: rural resilience participatory innovation digital innovation smart villages data analysis data valorization
Priests’ Books and the Popularisation of the Contemplative Life in England, 1300–1550 (PopLatin)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 2
Project status: SIGNED

PopLatin aims to write a new history of lay contemplative spirituality in the Middle Ages. Medieval people understood ‘contemplation’ as the highest religious experience: a revelation of divine love that could only occur, rarely, for those most committed to God. PopLatin offers a novel account of medieval contemplative spirituality by focusing on sources that scholars have largely overlooked: namely, the Latin textbooks that medieval priests used to teach their congregations. Latin priests’ books popularised famous medieval writers by transforming their teachings into more accessible forms, which priests then used to instruct their parishioners orally. The premise of PopLatin is that these neglected sources offer a new history of lay contemplative spirituality in the Middle Ages. By showing, counter-intuitively, that Latin was a language of popularisation through texts like these, PopLatin offers a radically revised view of what literature and beliefs ordinary laypeople could access during the centuries before the European Reformation. These objectives will be achieved through: literary analysis of four case studies, to establish how these Latin texts popularised the contemplative teachings of medieval authorities; analysis of material evidence, to show how priests communicated the teachings in their books to laypeople; survey of Latin priests’ literature, assisted by AI, to contextualise my research in wider trends; and literary analysis of the influence of Latin priests’ books on writers more famous today, to establish their importance for cultural history. This fellowship will enhance my career aim of securing a permanent academic position. It offers experience of a structured research project, which will ultimately form the basis of my next monograph, with one-to-one mentorship from a leading expert. It will develop my portfolio of teaching and public engagement, and enable me to contribute my knowledge of medieval Latin literature to research activities at UiB.

Keywords: medieval studies,history of religion,history of the book,theology,history of christianity
Development of a nanobody-based, slide-free approach for 3D-Histological analysis of the spatial tumor microenvironment using lightsheet imaging (3D-SpatiOmics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

For histopathological analysis and subsequent diagnosis of diseased tissues a rapid, accurate histopathological and genetic analysis of biopsied tissues are essential. However, traditional 2-dimensional slide-based histopathological analysis does not represent spatial tissue structures and molecular targets sufficiently, which aggravates an accurate and spatial analysis of tissue, a detailed description of the tumor microenvironment as well as patient stratification. To overcome these limitations, I propose an innovative, nanobody-based 3D-histopathology approach using non-destructive volumetric lightsheet-microscopy. This approach bears the potential to revolutionize the way pathological analysis of tumor samples are done. In comparison to conventional 2D-pathology, non-destructive 3D-histopathology allows rapid slide-free histological imaging of an entire tissue sample, volumetric analysis of diagnostic relevant structures such as immune cells, vessels and an improved spatial analysis of cell distribution relevant to study e.g. the microenvironment. To achieve this, we will generate nanobodies for improved wholemount tissue staining of the immune system as well as tumor-relevant markers. By labelling nanobodies with cleavable fluorescent dyes using click chemistry and integration of linkers for stoichiometric and directed labelling, we will be able to perform several rounds of multiplex staining of the identical sample and therefore provide cutting-edge diagnostic phenotyping of the specimen. Due to non-destructive nature of the optical-sectioning methodology, the sample is available for downstream applications such as molecular diagnostics of the previously imaged specimen. In summary, this innovative project holds the great potential to revolutionize cancer histology by providing a spatial and detailed description of the tumor microenvironment, improving diagnosis of tumor samples and consequently patient stratification and outcome.
Temporary inconvenience or early warning signs? A new take on maternal symptoms in early pregnancy and their consequences. (AuditeMatrem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1999740.0
EU funding (EUR): 1999740.0
Participants: 1
Project status: SIGNED

Pregnancy is a unique time of life where mother and child live in symbiosis. This relationship however induces multiple symptoms for mothers including nausea, vomiting, bleeding, pain, fatigue and many more. In their majority, symptoms pass without adverse consequences and are thus understudied. Instead of a temporary inconvenience, what if maternal symptoms were the key to understanding and preventing harmful consequences for both mother and child? So far, research on pregnancy has primarily focused on complications, maternal survival, and fetal health. Very little is known on the biological underpinnings of the wide range of symptoms mothers experience in the first half of pregnancy, leaving families and healthcare professionals inadequately informed about potential health consequences. Nausea and vomiting is a notable exception, where fetally-expressed proteins have recently been demonstrated to cause maternal symptoms. My recent research has further disentangled the respective contributions of the fetal and maternal genomes and characterized the trajectory of genetic signals over time. In addition, my team has established innovative approaches to study proteins accounting for haplotypic variation, paving the way for new research on how symptoms are mediated between mother and child. These findings open the opportunity to turn the tables, give overlooked maternal symptoms long overdue scientific attention, and unlock their potential in antenatal care. I hereby propose the creation of a new research framework that will 1) establish pregnancy profiles based on maternal symptoms, 2) reveal their genetic and proteomic underpinnings through the establishment of novel proteogenomic methods, and 3) resolve how maternal symptoms link to pregnancy complications and later health of mother and child. This transformative project will close a long-standing knowledge gap, opening novel research avenues for the study of pregnancy and its consequences for mothers and children.

Keywords: pregnancy
Function, role, and control of gigantic bacterial roll (Fun-ContRoll)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499568.0
EU funding (EUR): 1499568.0
Participants: 1
Project status: SIGNED

R-bodies are probably the largest organised intracellular proteinaceous structures in bacteria. They adopt a roll-like structure that occupies almost the entire cellular volume. Upon acidification, R-bodies extend telescopically up to 20 micrometres. First discovered in endosymbiotic bacteria, they were proposed to eliminate symbiont-free hosts, however their mechanism of toxicity remained unexplored. In addition, structures of similar composition and activity form ejectile defence organelles in Cryptomonads. Recently, we found that free-living environmental bacteria from the phylum Bacteroidota also produce R-bodies. In the Fun-ContRoll project we will study the assembly and conformational change mechanisms of these structures. We will investigate their mechanism of action and ask whether it depends on the extension or delivery of associated toxic effectors. To understand their biological role, we will explore hypotheses about their costs and benefits to the bacterial cell and to population. Alternatively, we will assess their role in establishing and maintaining the symbiosis. We will evaluate whether their biological role has pathogenic potential or, on the contrary, could help to eliminate parasitic species that cause disease and spread pathogenic bacteria. Finally, we will try to understand the strict regulatory mechanisms that controls the heterogeneity in the population, leading to a well-defined fraction of the population that produces these giant structures.

Keywords: symbiosis,inclusion bodies,organelles,macromelcular complexes,bacterial toxins,bacterial defense systems,population heterogeneity
Uncovering the cell of origin of Group 4 Medulloblastoma (ORIGIN4MB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: TERMINATED

Medulloblastoma (MB) is the most common malignant paediatric brain tumour, affecting mostly infants and children, and to a lesser extent adults. It originates from neuronal stem or progenitor cell populations on the cerebellum or brainstem during development and/or childhood, comprising around 60% of childhood intracranial embryonal tumours. The main risk factors associated with this condition are heritable factors, including germline mutations in genes that regulate developmental signaling pathways in the cerebellum. MB are classified in 4 subgroups (Wnt, Sonic Hedgeghog (SHH), Group 3 and Group 4) according to their gene expression, cell of origin, methylation patterns and clinical features. Group 4 MB is the most common subgroup of MB, affecting approximately 40% of the patients with this condition. The cellular origins of Group 4 MB are still under debate; however, recent papers using single cell RNA sequencing showed that Group 4 MBs are characterized by the expression of transcription factors such as Eomesodermin(EOMES) and LIM/Homeobox protein 2(LHX2) genes expressed by granule upper rhombic lip progenitors, more specifically Unipolar Brush Cells(UBCs) that are born during cerebellar morphogenesis. Therefore, one can hypothesize that Group 4 MB originates from UBCs progenitors. The main goals of the ORIGIN4MB project are to uncover the cell of origin of Group 4 MB and to develop the first pre-clinical model of Group 4 MB, revealing unprecendented insights in MB biology. To this end we will use lineage tracing techniques, lentiviral in utero infection, in vivo imaging and post-mortem analysis. We will also validate if the generated mouse model is able to recapitulate the human disease. This validation will determine if this model could be used to develop new treatments for Group 4 MB, opening the door to new therapeutic avenues for those pedeatric patients, ultimately improving their quality of life.

Keywords: medulloblastoma,cell of origin,mouse model,lentiviral infection,unipolar brush cells
Biomimetic collagen-based scaffolds for the study of pancreatic cancer and delivery anti-tumoural miRNA for enhanced cancer therapy. (PancmiR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

Pancreatic tumours are among the most aggressive, and are associated with the lowest survival rates. The main reason of this is their characteristic dense fibrotic stroma, which creates a perfect environment to promote cancer progression. To accurately mimic the Extracellular Matrix (ECM) is challenging, but is essential to understanding the interaction that occurs during malignant transformation. KRAS mutation is the most frequent alteration in pancreatic cancer. Micro(mi)RNA-143-3p and miRNA-216b have been shown to decrease KRAS gene expression and suppress tumour cell growth. My overarching Aim is to generate a 3D model of pancreatic cancer in which I can test the ability of a miRNA-activated scaffold to suppress tumour growth and facilitate local delivery of miRNA (miRNA-143-3p and miRNA-216b) that downregulate KRAS expression. Prof. Fergal O’Brien’s group in Royal College of Surgeon in Ireland has an extensive experience with development of biomimetic scaffolds to recreate the tumoural ECM and activating scaffolds to release therapeutic molecules (e.g., miRNAs). Using techniques established in his group, I will develop a 3D collagen-based scaffold that recreates the structure of pancreatic tumour ECM and then utilise this form as miRNA-activated scaffolds that will be used as local delivery systems in a radical new treatment for this disease. I will be supervised by Prof. O’Brien, and he will guide my Career Development Plan. I will develop complementary skills in project management, leadership, entrepreneurship, commercialisation, dissemination, and profile enhancement. Acquiring advanced research competences and complementary skills, I will maturate as an independent scientist, enhancing my professional visibility, capacity, and competitiveness in the field of biomaterials. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own biomaterials research group.

Keywords: scaffolds biomaterials collagen mirna pancreatic cancer nanomedicine