Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early Screening for Autism Spectrum Disorders in Health Care Settings (ASD SCREENING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-10-01
End date: 2012-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Researchers across the world are trying to understand precursors of autism spectrum disorders (ASD) and tools for the early identification of this disorder. Early identification is essential for enabling early intervention. Studies have shown that there are markers of ASD that can be detected in infancy among them deficits in joint attention and social interest. Available ASD screening tools have so far met with partial success in population screening thus cannot be employed in practice. Our goal is to study the predictive validity of ASD screening in infancy to later diagnosis, and the feasibility of ASD screening within the health care system. We will pursue our goal by conducting a two-stage screening study of a birth-cohort of 18-month old infants. At first infants will be screened with a parent questionnaire during their 18-month visit to baby wellness clinics. Screened negative infants will be further screened using a phone interview. Infants who continue to show risk for ASD will be administered a standardized diagnostic evaluation. A subset of children who screen negative will also be administered a diagnostic evaluation. This is crucial for identifying infants who were missed in the initial screening and for reducing bias of predetermined screening criteria. The efficacy of initial screening will be determined based on its prediction to diagnosis. Previous research by the PI, conducted mainly at Boston University and University of Massachusetts Boston, has shown that young children with ASD show sensory processing abnormalities early on. This proposal aims to expand upon previous research knowledge and experience with young children with ASD at the host institution. The host institution has world-class researchers in many of the disciplines to which early identification of ASD can be applied. We expect to interact and collaborate with researchers across the diverse fields at the host institution thus ensuring lasting reintegration.

Keywords: child psychiatry,epidemiology,autism,child development
Subjectivity and Selfhood in the Arabic and Latin Traditions (SSALT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Environment and society
Countries involved: Finland
Call:  (ERC-2007-StG, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 750000.0
EU funding (EUR): 750000.0
Participants: 1
Project status: CLOSED

The overall aim of the SSALT project is to throw light on the incubation of modern notions of the self and moral agency in the thought of the ancient world, their adoption and adaptation in the European and Arabic middle ages, and finally their transformation in the early modern period. This aim is approached through the twin paths of Arabic and Latin thought, both of which were in equal measure heir to the legacies of Greek rationalism and Hebrew monotheism. While most of the progress made so far in the scholarship has concentrated on Latin scholasticism, a more equally weighted investigation between the Arabic and Latin traditions can not only serve to bring to light much material that is of contemporary philosophical and ethical interest, but will also bring about a deeper understanding and appreciation of the Greek and Hebrew notions of selfhood and moral agency that form the bedrock of our culture. Once we begin to understand the similarities as well as the differences between the various thinkers frequently cited in the discussions (Aristotle and Descartes; Augustine and al-Ghazali; Avicenna and Aquinas), we can begin to discern what the theoretical implications are of committing to a certain philosophical viewpoint regarding human subjectivity and agency. Plainly, the importance of these findings reaches beyond the merely academic.

Keywords: philosophy of mind,philosophy of agency,islamic studies
Novel Temperature Regulating Fibres and Garments (NOTEREFIGA)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Sweden,Norway,Belgium,Germany,Finland,Belgium,Spain,Slovenia,Sweden,Netherlands,Romania,Romania
Call:  (FP7-NMP-2007-SME-1, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 3883338.2
EU funding (EUR): 2893390.0
Participants: 15
Project status: CLOSED

The objective of the project is to develop novel temperature regulating fibres and innovative textile products for thermal management, selected by the SME segment of the textile industry in Europe. The temperature regulating effect is achieved by novel methods of incorporating large amounts of phase changing materials (PCM) in textile fibres. When the body temperature increases, the PCM melts and absorbs the heat from the body in the form of latent heat. Then, when the temperature drops, the PCM crystallizes and the stored heat is released again. Clothes with built-in thermo-regulating properties provide maintained thermal comfort in difficult thermal environment and physical activity situations, without putting on or taking off clothes. Such smart clothing would reduce discomfort caused by accumulation of sweat/moisture in the clothing, and also shivering during varying activity levels and ambient conditions. The innovative concepts to be developed will outperform presently available materials for thermal management in garments. The concept is based on two main ideas. One idea is based on processing concepts that rely on compounding/mixing steps to provide suitable rheological properties of complex mixtures of polymers and PCMs followed by bi-component melt spinning to fibres with a core/sheath structure confining the PCM to the core. New bio-based (PLA) and conventional synthetic polymers for fibres (PP, PET, PA) are here addressed. The second idea is based on a new concept for incorporating PCMs in wet spun cellulose fibres based on direct addition of free PCM to a cellulose solution. A large and intense part of the project will be devoted to product related research, lead by the SMEs in the project. In particular, specific, value-added products are targeted within underwear, sports, leisure and home textiles. The work will aid in the transformation of the European textile and clothing industry from commodities into specific, value-added high-tech products.

Keywords: temperature regulating fibres,melt spinning,garments,cellulose,wet spinning,thermal management,textiles,phase changing materials
Acency Costs and Asset Pricing (ACAP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-11-01
End date: 2014-10-31
Duration (months): 72.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

The main objective of this research project is to contribute at bridging the gap between the two main branches of financial theory, namely corporate finance and asset pricing. It is motivated by the conviction that these two aspects of financial activity should and can be analyzed within a unified framework. This research will borrow from these two approaches in order to construct theoretical models that allow one to analyze the design and issuance of financial securities, as well as the dynamics of their valuations. Unlike asset pricing, which takes as given the price of the fundamentals, the goal is to derive security price processes from a precise description of firm’s operations and internal frictions. Regarding the latter, and in line with traditional corporate finance theory, the analysis will emphasize the role of agency costs within the firm for the design of its securities. But the analysis will be pushed one step further by studying the impact of these agency costs on key financial variables such as stock and bond prices, leverage, book-to-market ratios, default risk, or the holding of liquidities by firms. One of the contributions of this research project is to show how these variables are interrelated when firms and investors agree upon optimal financial arrangements. The final objective is to derive a rich set of testable asset pricing implications that would eventually be brought to the data.

Keywords: corporate finance,asset pricing
Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs. (PHOTOCHROMES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Sweden
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

Photochromic molecules, or photochromes, can be reversibly isomerized between two thermally stable forms by exposure to light of different wavelengths. Upon isomerization, properties such as excitation energies, redox properties, charge distribution, and structure experience significant changes. These changes can be harnessed to switch “on” or “off” the action of a variety of photophysical processes in the photochromic constructs, e.g., energy and electron transfer. Until now, the focus of my research has been to show proof of principle for a large selection of molecule-based photonically controlled logic devices (solution based) with the functional basis in the switching of the transfer processes mentioned above. Now, I wish to extend the study to include experiments in the solid state, e.g., polymer matrices. Taking the step into doing solid state chemistry is not only a prerequisite for any real-world application. It will also allow for experiments that cannot be performed in fluid solution, such as aligning molecules in a stretched film for chemistry with polarized light, and immobilization of molecules for selective addressing in a three-dimensional array of volume elements. Furthermore, I intend to investigate the possibility to photonically control the membrane penetrating and the DNA-binding abilities of photochromes, aiming at, in a long-term perspective, light-activated cancer drugs. Due to the fact that both the structure and the charge distribution of a photochrome may change drastically upon isomerization, one of the two isomeric forms is often suitable for penetrating a membrane. Inside the membrane, e.g., in a cell, the photochrome can be photo-isomerized to a structure with high affinity for strong binding to DNA. Upon binding, transcription is inhibited and the cell dies. If desired, pH-sensitivity and two-photon processes could be used to further increase the selectivity in addressing very specific regions of the body, such as a tumor.

Keywords: photochromes,molecular electronics,solid state,dna-binding,membrane penetration,cancer drugs
INTEgrating and Strengthening GEnomic Research in South-Eastern Europe (INTEGERS)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Croatia
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 535100.0
EU funding (EUR): 478647.5
Participants: 1
Project status: CLOSED

Over the past decade significant resources have been committed to development of capacities for genomic research in Croatia. These efforts have lead to formation of the Centre for Functional Genomics of the Faculty of Medicine and University Hospital, University of Zagreb. Within the national confines, Centre for Functional Genomics formed strong links with other Croatian groups interested in genomic research, as well as with recognised centres of excellence in European Union (in Scotland, Portugal and Germany), and also with the Harvard University (USA). Initially formed through common research interests, these collaborations resulted in award of several research grants from the Croatian Ministry of Science, as well as international grants with EU partners (from The British Council, Royal Society UK, The Wellcome Trust, Medical Research Council UK, National Institutes of Health USA and European Union). This proposal therefore seeks to strengthen and reinforce Centre for Functional Genomics of the Zagreb Medical School and its existing links with Croatian and EU centres. The timing in Croatia is now very favourable for building on recent successes that include employment of promising researchers in the field of genomics, securing substantial competitive international research funding and publication of research results in high-impact journals. Support from the European Commission to this initiative would secure further development of genomic advances in the Croatian biomedical scientific community, integration of existing capacities within the country and bolstering the links with international centres of excellence to ensure the sustainability of existing programmes. These activities could also have potential impact on local economy, social environment and health. This would result in creation of a highly competitive group of scientists from the EU convergence regions that could get involved in further applications within the EU FP7 program.

Keywords: genomics,proteomics,matabolomics,capacity building,mobilisation of human resources
Role of innate immunity in the pathogenesis of autoimmune diseases (RIISPAD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-03-01
End date: 2012-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We propose a multidisciplinary “translational research” project that will exploit the molecular and cellular features of innate immunity potentially involved in the pathogenesis of autoimmune diseases in humans. Given the significant scientific advances over the past years in characterizing the physiology of cells from the innate immune system, we will attempt to identify the role of natural killer (NK) cells and dendritic cells (DCs) in the physiopathology of various autoimmune disorders. Combining different professional expertise in clinical and basic immunology, we plan the following: 1) To select cohorts of patients affected by several systemic autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (scleroderma) and other various forms of vasculitis. We will conduct our investigations on both naive untreated patients with active disease and patients undergoing immuno-suppressive therapy with disease in remission, in either cross-sectional or longitudinal studies 2) To collect total peripheral blood lymphocytes through either blood draws or leukapheresis procedures in order to obtain large numbers of cells for analysis. 3) To identify significant aberrancies in the phenotype and functions of NK cells and DCs that may further our understanding of the physiopathology of autoimmunity. 4) To better understand how innate and adaptive immunity are linked and whether aberrant interactions between the two arms of the immune system lead to the lack of immunological tolerance in autoimmune disorders, in order to develop alternative therapeutic approaches to autoimmune disorders 5) To develop new diagnostic tools that better characterize the status of innate immune competent cells and improve classification of the stages of autoimmune disorders, which could lead to a more effective use of immunosuppressive agents.

Keywords: medical sciences,medicine,immunology,pathogenesis of human diseases
Design, Synthesis and Biological Evaluation of HIV-1 and HCV inhibitors (ANTIVIRAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-09-03
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In the proposed study we aim to investigate novel Human Immunodeficiency Virus (HIV) and Hepatitis-C (HCV) inhibitors that will improve the quality of life of the infected patients, reduce or avoid the toxic effects of the current treatment and ultimately assist in the eradication of these viruses. The current treatment for HIV that includes inhibitors of viral entry, protease and transcriptase activity, is compromised by the persistence of viral reservoirs, drug resistance and adverse side effects. HIV-1 integrase (IN), the enzyme responsible for integrating the viral DNA to the host genome, is essential for viral replication and represents an ideal target for drug design. The current treatment for HCV of interferon-α and ribavirin has demonstrated limited success in treating all genotypes and alternatives with improved efficacy represent an important unmet need. The HCV NS2-3 and NS3-4A proteases and the NS5B RNA dependent RNA polymerase are an essential component of the viral maturation and replication and are thus, ideal targets for the development of new anti-HCV inhibitors. In the course of this project, we will explore the design of novel inhibitors that will target the viral enzyme IN, the HCV NS2-3, NS3-4A proteases and the NS5B RNA dependent RNA polymerase. In our study we will introduce state-of-the-art technologies; we intend to employ a de novo computer-aided drug design method for designing novel inhibitors of IN, NS2-3, NS3-4A and NS5B viral proteins, design synthetic routes for their preparation and develop specific assays for the aforementioned viral proteins. The creation of new medicine necessitates efforts in multiple directions and requires collaborations between research institutes, here the University of Cyprus (UC, host institute) and the Scripps Research Institute (TSRI). The proposed project is expected to enhance scientific excellence and competitiveness in the pharmaceutical sciences and innovative drug research carried out in the EU.

Keywords: inhibitors,hiv-1 integrase,hcv,de novo design
Financial Services Governance in the European Union (FINGOVEU)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Institutions, values, beliefs and behaviour
Countries involved: United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2008-10-01
End date: 2012-03-31
Duration (months): 42.0
Total project cost (EUR): 377464.0
EU funding (EUR): 377464.0
Participants: 1
Project status: CLOSED

This project examines the governance of financial services in the European Union (EU). This research is both academically interesting and policy relevant. Academic research has not kept pace with new developments in this field, and interdisciplinary research is very much needed, as financial services governance is at the cross road between politics, economics and law. At the practical level, the financial sector is a core part of national economies and one of the most active areas of EU policy making. Moreover, this research will contribute to informing the public discussion in a policy area that is often perceived as 'technical', which tends to limit the public scrutiny of it. For the purposes of this research, the governance of financial services in the EU includes: i) the institutional framework through which policies are made; ii) regulation, which is comprised of market-making and market-framing measures; and iii) supervision, that is: the monitoring and enforcement of regulation as well as the practical cooperation between supervisory authorities. First, the project will map the complex institutional framework underpinning financial services governance in the EU, explaining how such framework interplays with regulatory and supervisory arrangements in international arenas and in selected countries. Second, through competitive hypotheses testing, the project will analyse the EU policy-making processes in the financial sector: the main policy-makers and stakeholders involved; their resources, relationships and influence on the policy process; and the outcome. Besides contributing to the policy-oriented debate on financial services regulation and supervision in the EU, the ultimate theoretical goal of the research is to devise an integrated analytical framework that by combining various theoretical approaches and identifying their scope conditions could account for financial services governance in the EU, advancing theories of EU policy making.

Keywords: financial services,governance,lamfalussy framework