Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Disruptive Regulatory Technology for Asset Management Industry. FinTech company changes the global Asset Industry forever (Fundsphere Terms)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2019-03-31
Duration (months): 30.0
Total project cost (EUR): 2565740.0
EU funding (EUR): 1796018.0
Participants: 1
Project status: CLOSED

The continued use of a paper-based Contract Lifecycle Process in the Asset Management Industry creates needless inefficiencies, errors, risk and limitations. Asset Managers using state-of-the-art spreadsheets and document assembly tools find their paper chaos transformed into even bigger digital chaos without meaningful improvement of current methods. Furthermore, recent financial regulations (MiFID II in EU, RDR in UK, Dodd-Frank Act in USA) reinforce the need for disruptive technologies to stay competitive in the new investor environment. Metrosoft is set to revolutionize the way the agreements are created and managed in the Asset Management Industry. Fundsphere Terms is a native digital platform that creates, manages and exchanges legal agreements covering Terms of Business between the Sell Side and the Buy Side in a structured database solution. The benefits of such dematerialisation have been demonstrated in the successfully finalised Phase 1 Feasibility Study: Fundsphere Terms disrupts current contract creation by simplifying the workflow and speeding up the process from months to weeks and in the case of amendments from weeks to a single day. The need for Fundsphere Terms was confirmed by key finance firms during the two biggest sectorial conferences in Luxembourg and Hong Kong (ALFI, ITAS) and Key Opinion Leaders who are strong supporters of industry dematerialisation. To fully exploit this EU-based technology, we will drive growth through B2B model and target the top 400 Assets Manager decision-makers and industry influencers. Later growth will be by “snowball effect” (counterparties of Assets Managers). By bringing Fundsphere Terms into the rapidly growing market we estimate to attract min. ≥ 25% of the global Asset Managers, which means volume of approx. +/-20 customers annually, with an estimated revenue €17.4mln after 5 years.

Keywords: software platform,asset management,fund distribution,transparency,mifid ii,dmfsa,dematerialization,data driven,legal agreements,investor protection
indoor small-cell Networks with 3D MIMO Array Antennas (is3DMIMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,China,Netherlands,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1309500.0
EU funding (EUR): 877500.0
Participants: 8
Project status: CLOSED

It is predicted that wireless network traffic will increase 1000 times in the next decade. The exponential traffic growth is not uniform across geographical areas and mainly takes place in indoor hot spots. Hence, high capacity indoor venues represent the biggest network capacity increase challenge. The recently emerged 3D MIMO technology provides a promising dimension to provide extra capacity gain in hot spots. In particular, the 3D deployment of small cells (SCs) equipped with 3D MIMO antenna arrays will take advantage of 3D distribution of user equipment (UE) in typical high capacity venues, and represents an excellent technical combination to address the indoor high capacity challenge. The 3D deployment of SCs with 3D MIMO antenna arrays faces technical challenges ranging from 3D MIMO antenna array design, performance evaluation, the lack of understanding of 3D MIMO SC network performance limits to the optimal 3D SC network deployment. The is3DMIMO project aims to address these technical challenges by assembling a team of four partners in the UK, Sweden and China with complementary expertise. During the project, the is3DMIMO consortium aims to achieve the following objectives: • characterize and model indoor 3D MIMO channels for typical indoor environments; • develop a reliable OTA antenna characterization method for 3D MIMO SCs; • characterize OTA performance in laboratory conditions as compared to real-life 3D MIMO small cell scenarios; • obtain fundamental understanding of the network performance gains achievable by 3D SCs with 3D MIMO antenna arrays; • develop techniques for jointly optimizing the deployment locations of SC access points (APs) and their 3D MIMO configurations; and • provide 3D MIMO SC network planning and deployment guidelines for typical 3D indoor scenarios. The achievement of the above objectives will provide crucial inputs for multiple-antenna and 5G/B5G system design, and will increase network capacity in indoor hot spots by 20-30%.

Keywords: small cells,heterogeneous networks,3d mimo,array antennas,indoor environments,channel modelling,network optimization
Functional analysis of thyroid hormone nuclear receptors TRs in human Intestinal Cancer stem cells (FUNTRICAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 116953.92
EU funding (EUR): 116953.92
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women worldwide. Although some CRCs are effectively treated through the standard strategy of surgery, radiation and/or chemotherapy, some patients have a recurrence of their cancer and a spread to other parts of the body that threatens life. Despite decades of research, we are unable to predict which cancers will be effectively treated and which are likely to spread. In support of the well-documented resistance of cancer stem cells (CSCs) to conventional therapies high stem cell (SC) signature scores statistically associate with a high risk of tumor relapse in patients. Targeting CSCs thus constitute a determinant medical issue and identify novel players of SC plasticity is a prerequisite to open novel therapeutic avenues. Using ex vivo organoid cultures, we recently demonstrated that thyroid hormones (THs) reduce the pool of intestinal SCs by triggering premature cell differentiation. Even if the underlying mechanisms remain elusive, our preliminary results tend to demonstrate that the TH-induced loss of stemness relies on a profound modification of the ratio between TRα1 and TRβ1 (TRs), with deep consequences on the expression of WNT and NOTCH downstream target genes. My proposal will pave the way for a unique focal area in the field of CSCs. Combining original approaches such as ex vivo 3D human colosphere and organoid cultures, in vivo CSC tracing experiments as well as innovative proteome mapping techniques (BioID and APEX2) I aim to address the potential interest of disrupting the THs/TRs balance in order to enforce CSC differentiation with the final aim to eradicate them by conventional therapies. Furthermore and more importantly, by minoring CSC plasticity, it will strongly reduce their adaptability to stress conditions and limit escape mechanisms.

Keywords: colon cancer,cancer stem cell,cell plasticity,cell differentiation,thyroid hormone receptors,organoid
A multimodal approach to accelerate drug discovery and development in Alzheimer’s disease (MAP-AD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: SIGNED

Alzheimer’s disease (AD) is a major societal challenge, impacting up to one third of the population over 85 years old. The European Commission and various international bodies have repeatedly fostered research initiatives to prevent the development or stem the progression of the disease. Several recent phase 3 clinical trials have failed to show any efficacy in slowing disease progression, calling into question the current drug targets. This project will use genetic data to identify new AD-relevant molecular pathways and their associated drug targets. Given the increased risk of AD in women, we will apply our innovative analyses not only to autosomal variants but also to X-chromosome variants as well. The mechanistic effects of genetic variants on pathogenesis will be delineated using gene expression from post-mortem brain tissue and AD biomarkers derived from multimodal brain imaging studies. These in-vivo PET and MRI biomarkers are essential for enrolling patients correctly in clinical trials and assessing the effect of treatments on disease progression. We will assess whether a polygenic risk score, based on thousands of genetic variants, will be useful in predicting an individual’s clinical and biomarker progression over time. This project is markedly interdisciplinary in nature between its analysis of multimodal brain imaging and genomics data, and the combination of big data analysis guided by expert medical knowledge of the pathogenesis. Results have the potential to (i) identify new drug targets and (ii) strengthen clinical trial design, thereby speeding the development of drugs for the prevention and treatment of AD. This fellowship represents a unique opportunity to transfer knowledge and analysis methods of next generation genomics AD data from one of the leading US groups in integrating multimodal imaging and genomics data to the European AD research community.
TRAVELING WAVES: Defining the mechanisms allowing attention to occur in space and in time (WAVES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1480940.0
EU funding (EUR): 1480940.0
Participants: 1
Project status: SIGNED

Brain oscillations have always fascinated both scientists as well as the general public, but their functional role remains ill defined. My research contributed to addressing this issue, and demonstrated that oscillations modulate attentional performance periodically in time. Oscillations create periodic windows of excitability, with more or less favorable periods recurring at particular phases of the oscillations. However, attention emerges from systems not only operating in time, but also in space. Previous research has emphasized the temporal aspect of brain oscillations’ behavior. Contemporary investigators rarely consider both temporal and spatial dimensions in their search for the mechanisms linking oscillations and attention. This is the challenge I propose to take on. I will address this essential question: How does the spatio-temporal organization of brain oscillations impact attention? I hypothesize that oscillations propagate over the cortical surface, so-called oscillatory Traveling Waves, allowing attentional facilitation to emerge both in space and time. I propose to test this original hypothesis using a model-based multimodal functional neuroimaging approach including non-invasive and invasive recordings in humans. Interventional approaches will additionally be used to evaluate the degree of causality in the relation between traveling waves and attention. This project could lead to major progress in cognitive psychology and neuroscience by bridging the gap between spatial and temporal dynamics underlying multi-sensory experience. An important methodological development is also expected. The model-based multimodal functional neuroimaging approach that I will develop and evaluate on a large set of data will provide a new methodological guide for the study of brain activity.

Keywords: oscillations
Better control and treatment of immune-mediated diseases by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies (ImmUniverse)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Italy,Germany,Italy,Austria,Austria,Italy,Germany,Belgium,Belgium,Sweden,Belgium,Switzerland,Belgium,France,Netherlands,Netherlands,Denmark,United Kingdom,Luxembourg,United Kingdom,United Kingdom,United Kingdom
Call: Microenvironment imposed signatures in tissue and liquid biopsies in immune- mediated diseases (H2020-JTI-IMI2-2018-15-two-stage, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 31110000.0
EU funding (EUR): 15500000.0
Participants: 29
Project status: SIGNED

Immune-mediated diseases (IMIDs) are an increasing medical burden in industrialized countries worldwide. IMIDs are characterized by an enormous heterogeneity with regard to disease outcome and response to targeted therapies, which currently cannot be adequately anticipated to tailor individual patient management. Hence, mechanistic understanding of this heterogeneity and biomarkers predictive for disease control and therapy response over time are important prerequisites of a future precision medicine in IMIDs. ImmUniverse has been formed as a European transdisciplinary consortium to tackle these unmet needs and to understand the role of the crosstalk between tissue microenvironment and immune cells in disease progression and response to therapy of two different IMIDs: ulcerative colitis and atopic dermatitis. Following this unique cross-disease approach ImmUniverse will fill the gap and the limitations of current studies, which do not systematically compare the complex interactions between recirculating immune cells and the respective tissue microenvironment. The consortium will combine analysis of tissue-derived signatures with “circulating signatures” detectable in liquid biopsies, employing state-of-the-art profiling technologies corresponding to multi-Omics datasets. The project will also bring diagnostics in IMID to a new level by implementing disruptive non-invasive liquid-biopsy methodology in combination with novel, validated circulating biomarker assays which are expected to improve diagnosis, inform early in the clinical course on disease severity and progression and enable treatment response monitoring. The identified signature will be validated to monitor state/progression and response to therapy in prospective observational cohorts. Realization of these objectives will result in improvement of patient management, lead to increased patient well-being and will significantly reduce the socioeconomic burden of these diseases.

Keywords: skin,immune mediated diseases,multi omics,liquid biopsy,immune profiling,response to therapy,atopic dermatitis,ulcerative colitis
Integrated Assessment of Atlantic Marine Ecosystems in Space and Time (iAtlantic)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Australia,South Africa,Iceland,Germany,Germany,Spain,Argentina,Sweden,Belgium,France,France,United States,Netherlands,Denmark,United Kingdom,United Kingdom,Canada,Brazil,Mexico,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: All Atlantic Ocean Research Alliance Flagship (H2020-BG-2018-2, 2018)
Start date: 2019-06-01
End date: 2023-05-31
Duration (months): 48.0
Total project cost (EUR): 10803099.0
EU funding (EUR): 10631224.0
Participants: 43
Project status: SIGNED

iAtlantic will take an interdisciplinary scientific approach to unifying stakeholder efforts to better inform sustainable management and enhance human and observational capacity throughout the Atlantic. The integration of ecosystem data with major circulation pathways connecting the North and South linked with climatic data and forecasts provides a systematic approach to jointly assess and tackle policy challenges. Ocean physics and ecosystem connectivity will enable high-resolution oceanographic hindcasts and forecasts of future circulation together with ground-truthing genomic data. Advances in eDNA genomics, machine learning and autonomous underwater robotics will be combined with existing data to provide a step-changes in predictive habitat mapping approaches to expand species and biodiversity observations from local to basin-scales. Ecological timeseries, including innovative palaeoceanographic and genomic reconstructions, will provide an unprecedented view of the impacts of climate change on Atlantic ecosystems. Assessment of the impact of multiple stressors will identify key drivers of ecosystem change and tipping points. New data will come from 12 carefully selected regions in the deep sea and open ocean that are of international conservation significance and of interest to Blue Economy and Blue Growth sectors. Innovative and efficient data handling and data publishing approaches will establish a better integrated Atlantic Ocean observation data community. Capacity and cooperation between science, industry and policymakers bordering the Atlantic will be boosted by joint multi-disciplinary research cruises, enhanced S Atlantic monitoring arrays, scientific training events, iAtlantic Fellowships and industry focussed workshops. Results will be used to stimulate dialogue with stakeholders and critically assess current ocean governance frameworks generating increased capacity for Marine Spatial Planning and enabling Blue Growth scenarios to be rapidly evaluated.

Keywords: deep sea,benthic,pelagic,oceanography,modelling,seabed mapping,ecological timeseries analysis,multiple stressors,tipping points,environmental dna,genomics,marine policy,governance
Making heating and cooling for European consumers efficient, economically resilient, clean and climate-friendly (REPLACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,Spain,Austria,Serbia,Bulgaria,Croatia,Slovenia,Bosnia and Herzegovina
Call: The role of consumers in changing the market through informed decision and collective actions (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-11-01
End date: 2023-04-30
Duration (months): 42.0
Total project cost (EUR): 1999878.75
EU funding (EUR): 1999878.75
Participants: 12
Project status: CLOSED

With over 80 million inefficient heating & cooling (HC) systems still installed across Europe motivating consumers to replace those units with more efficient, greener alternatives will be key for a decarbonised Energy Union fuelled by renewable energy. REPLACE therefore aims to improve coordination in local networks to implement replacement campaigns in ten target regions by means of action plans fortified with policy and business-related improvements. Based on lessons learnt from previous projects and sound on-the-ground research on stakeholders’ mind-sets, local working groups (LWGs) will connect all key actors in each region – local governments, consumer associations, developers, energy utilities and professional associations – to steer the direction of a wide range of replacement activities. For the first time, REPLACE will explicitly unite intermediaries, such as chimney sweepers or installers, who have constant access to consumers, and policy makers to develop common activities with maximum impact. REPLACE supports the LWGs by providing a communication framework and a rich toolbox of online and offline actions targeted to the needs of all relevant stakeholders. The “REPLACE Your Heating System Calculator” will be central in raising consumers’ and investors’ awareness of the monetary and wider benefits of HC replacements and develop real momentum towards collective actions. By making all materials openly accessible and highlighting success stories the uptake of activities can be multiplied beyond target regions. In addition, all activities will be firmly established within local policy programmes to ensure that the overall impact of REPLACE is sustainable and the networks forged during the action will continue beyond project life. Together with a dedicated focus on capacity-building measures and knowledge transfer REPLACE identifies and merges all elements necessary to successfully make heating and cooling for European consumers efficient and climate-friendly.

Keywords: renewable heating and cooling rhc systems,replacement of inefficient hc and domestic hot water preparation systems at households,demand response,collective actions,consumer oriented campaigns