Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multi-Material Thermoplastic high pressure Nitrogen Tanks for Aircraft (TRINITI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Ireland,Italy
Call: Multi-Material Thermoplastic high pressure Nitrogen Tanks for Aircrafts (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-06-30
Duration (months): 33.0
Total project cost (EUR): 819071.25
EU funding (EUR): 649999.88
Participants: 3
Project status: CLOSED

TRINITI aims at developing and demonstrating concepts and methodologies enabling the realization of an integrated multi-material airborne pressure vessel for longterm storage of nitrogen, in particular a halon-free fire extinguishing system employing water-mist and nitrogen. TRINITI’s tank has been conceived to fulfill technical requirements foreseen by the CfP e.g. very low permeation of gases, mechanical loads according to RTCA Do160 Rec. G, good fire-smoke-toxicity (FST) properties, survival of high temperatures, large temperature gradients, as well as resistance against various chemical media. Demonstration multi-material thermoplastic tanks will be fabricated through a combination of processes such as co-extrusion of thermoplastic materials to form a multi-layer and multifunctional thermoplastic material, followed by In-situ consolidation Laser-Assisted Automated Fiber Placement process. The application of highly performing thermoplastic materials combined with advanced automated and out-of autoclave technologies on the one hand will answer to the need for less consuming and faster manufacturing processes (1 stage process), while on the other hand it will ensure reduced weight of the tank, reduced operational costs as well as reduced fuel consumptions and emissions of an aircraft. TRINITI's linerless tank, thanks to the versatility of the Laser assisted AFP antropomorphic robot and possibility to use a dedicate simulation tool to optimise the design of the vessel, is expected to range not less than 10% lighter than their nearest Type IV tanks. A better weight-to-tank capacity ratio, however, is not the only advantage of the high pressure vessel, in fact a significant manufacturing cost flow reduction is expected mainly because the chain of manufacturing processes will be optimized and number of fabrication stages will be reduced. Consortium will aim to reach at the end of the project TRL 6.

Keywords: nitrogen tank,multi material thermoplastic tank,afp thermoplastic tank,in situ consolidation afp,automated composites manufacturing
Proactive FET Observatory for early trends, project building and social responsibility (PREFET)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Spain,United Kingdom
Call: FET-Open Coordination and Support Actions (H2020-FETOPEN-2018-02, 2018)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 552187.5
EU funding (EUR): 552187.5
Participants: 4
Project status: CLOSED

Coming up with radically new ideas based on excellent science and being able to materialize it with real benefits for the society is a tremendous challenge. It not only relies on the capability and inspiring potential of the researchers, but in the suitability and synergy of other factors of very different nature: society perception, economic/political context, gender/ethic issues, or its matching with real social needs. Early detection of this type of ideas and resources facilitation is key to enable the kick-off of promising future technologies. The EU has developed several programs for giving financial support to these technologies, although competition is fierce, on one hand, and a considerable proportion of proposals submitted does not reach the quality threshold, on the other hand. PREFET will address the former challenges by creating a methodology platform which will connect the three pillars we consider essential for a successful design and use of FET: a) technology trends detection and analysis combining the most advanced AI engines with human intelligence and social perception; b) RRI trends analysis (and their social impact) and tools for best practices and implementation, especially aligned with the 2030 Sustainable Development Goals, and c) innovation capacity building. This means going beyond the observatory position and proactively detecting, engaging and supporting researchers with high potential to become FET winners, underpinned by the responsible research approach. RTDI, Linknovate, Trilateral Research and De Montfort University, have extensive experience in the field of technology watch, trends analysis, project ideation & project building and RRI implementation. Thanks to their own research activities and innovative methodologies, together with the know-how of FET context, we really feel that PREFET will address the need of boosting the European leadership force and create long-term innovations of great benefit for society.

Keywords: proactive trends observatory,fet rri integration,capacity building,human intelligence augmentation,artificial intelligence,sustainable development goals,innovation skills,open trend consultation
Up-frameshift protein interactions in translation termination and nonsense-mediated mRNA decay (UPFs_NMD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

In eukaryotes, gene expression is highly regulated involving multistep pathways in which mRNA plays a crucial role. Cells have evolved surveillance mechanisms able to detect and degrade defective transcripts. Nonsense-mediated mRNA decay (NMD) is a mRNA surveillance mechanism which detects faulty mRNAs with premature termination codons (PTCs) and targets these transcripts to decay. By modulating the expression of physiological mRNAs, NMD acts as a post-transcriptional regulator controlling important cellular processes in development, stress response, immunity and neuronal differentiation. NMD is of medical importance because mutations or copy number variations of the NMD factors are implicated in human neurological disorders, intellectual disability, schizophrenia, autism, immune diseases and cancer. The mammalian NMD machinery comprises the proteins UPF1, UPF2, and UPF3B, eukaryotic release factors (eRF1 and eRF3a), SMG1 kinase and SMG5-9. Recently UPF3B was found to have a role in translation termination at a premature stop codon, interacting directly with the ribosome, release factors and UPF1, requiring modification of prevalent NMD models. To understand the molecular mechanisms of UPF3B and its role in NMD, this proposal aims to determine the molecular architecture of UPF3B in complex with UPF1, ribosome and mRNA. Furthermore, I will explore the role of the helicase and ubiquitin ligase activities of UPF1 in NMD and protein decay. I will use biochemistry, biophysics, X-ray crystallography and cryo-electron microscopy to identify the UPF3B domains involved in the recognition of NMD substrates and to investigate how UPF3B binding to the UPF1-RNA complex helps trigger mRNA decay. Such information will shed light on how translation termination and assembly of the NMD machinery are coordinated and therefore will be of key importance for the future development of therapeutic approaches for the future development of therapeutic approaches for NMD- related diseases.

Keywords: non sense mediated decay,mrna quality control,mrna surveillance,translation termination,ribosome,upfs proteins,biophysics,protein protein interactions,proteomics
Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration (SkinTERM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Switzerland,Netherlands,Netherlands,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-10-01
End date: 2025-07-31
Duration (months): 58.0
Total project cost (EUR): 3192735.96
EU funding (EUR): 3192735.96
Participants: 9
Project status: SIGNED

Transplantation of autologous split-thickness skin -the epidermis with a tiny layer of dermis- remains the golden standard for various skin wounds like burns and large trauma. This treatment, however, comes with a number of serious drawbacks, including pain, mobility-limiting contractures and disfiguring scars. The SkinTERM consortium will address wound healing in a completely different way, recapitulating (certain aspects of) skin embryonic development in adults, and aiming for regeneration rather than repair. Skin organogenesis will be induced by key elements taken from the extracellular matrix of foetal and non-scarring species and by employing (stem) cells from relevant cellular origins. The starting point for the study is the remarkable capability of early foetal skin and skin from the spiny mouse (Acomys) to heal perfectly without scars/ contraction and with appendices such as hair follicles. Novel biomaterials and skin substitutes will be developed and evaluated. In order to effectively embrace this new approach, the PhD students need to have knowledge in key elements of basic science, regenerative medicine and biomaterial sciences. As translation to medical devices and especially advanced therapy medicinal products is currently too limited, we will give the PhD students a solid theoretical and practical foundation on topics like regulatory affairs, GMP and GCP, as well as secondments in industry. Driven by both the enthusiasm to gain basic scientific insights and the need for efficacious and innovative therapies, the students will acquire expertise through cutting edge scientific projects and will be trained by leading experts in all required skills to further develop their scientific findings into real life-science products. The SkinTERM program will thus create a new generation of entrepreneurial, multidisciplinary and inter-sectorially trained scientists with excellent career perspectives in either academia, industry or government.

Keywords: biomaterials,skin regeneration,stem cell biology,scarring,contraction,wound healing
Catalytic Csp3-H functionalization via carbene insertion meets sustainability: Developing an unprecedented Iron methodology (FeCHACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Proposed to break new ground quickly and to establish new frontiers in cutting-edge Csp3-H functionalization chemistry, this proposal focuses on the development and exploitation of iron catalysed carbene transfer towards saturated hydrocarbons, a vast and low cost feedstock for the synthesis of more valuable chemicals. By rational design and evaluation of low toxicity and low cost iron complexes equipped with different electronic and steric properties, new environmental benign and sustainable catalytic strategies will be instilled into this promising synthetic methodology. Extending beyond the confines of traditional precious metals catalysed carbene transference, new non-hazardous sources for these fragments, compared with the currently employed diazocompounds, will be designed and refined in sulfur ylide compounds and zinc carbenoid reagents. The project will benefit from the accumulated wealth of experience of the candidate Dr. Hernán-Gómez in synthesis, characterization and kinetic studies of highly reactive organometallic reagents, spanning from transition metals to main group elements. This will offer valuable mechanistic insights into the investigated processes, including unequivocal identification of the catalytic active species, key aspects to progress the proposed project. Additionally, through collaboration with supervisor Prof. Costas, an internationally recognised leader in the chemistry of iron compounds applied to organic synthesis, Dr. Hernán-Gómez will be provided with the required support to successfully push forwards the frontiers of the proposed research line in the field of iron chemistry, a stepping stone towards achieving a senior academic position.

Keywords: iron chemistry,carbenes,alkanes functionalization,catalysis,kinetics,x ray characterization
FORMAT: a novel medium FOr Revolutionizing stem cell MAnufacturing Technologies (FORMAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

One of the greatest challenges facing society is treating patients afflicted with degenerative and age-related disorders, such as multiple sclerosis, Parkinson’s disease and diabetes. For all of these, stem cell therapy represents a novel treatment approach and a great hope for the millions of patients worldwide. In my ERC-funded research project, we successfully managed to generate Extracellular-signal-Regulated Kinases (ERK) signalling independent human naïve Pluripotent Stem Cells (PSCs), a new category of human stem cells that retrain features that are characteristic of earlier developmental stages, i.e. they are more “primitive” than typical/conventional human PSCs. We managed to do so by employing a novel medium that allows the acquisition of many apparent naïve features that were previously observed only in rodent pluripotent stem cells. Importantly, this new pluripotent configuration, not only comes in different molecular flavours, but also has different functional properties. In turn, the first goal of our PoC project is to establish the technical feasibility of our novel medium by carrying out a series of molecular and functional tests. Such tests would enable us to further improve the existing medium conditions and create a commercial-like platform for enhanced expansion and derivation of human naïve induced PSCs. The second goal of FORMAT project is to establish the commercialization potential of our novel medium as a means to maintain standardized cells that can in turn be used to replenish, regenerate and repair damaged human tissues.

Keywords: stem cells,pluripotency,induced pluriptoent stem cells ipscs,cell therapy,tissue culture production
Unravelling the pRotein Allosterome of Gene Expression (proteoRAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1684594.0
EU funding (EUR): 498668.37
Participants: 2
Project status: SIGNED

Understanding how different environmental cues influence cellular physiology is critical but challenging. Small molecule metabolites such as nutrients and signalling molecules carry information about the external and internal state of the cell. Proteins sense these environmental signals through direct physical interactions with metabolites that trigger rapid variations of protein activities as response. Those events where protein and metabolites interact leading to functional consequences are called allosteric interactions. Allosteric interactions are classically studied in the context of enzymatic reactions, but much less is known regarding their potential ability to control gene expression. I propose to test the hypothesis that metabolites can, in some cases, bypass classical signaling pathways and act directly on gene expression. To address this question, I will study systematically the proteins that regulate gene expression (i.e. transcription and translation) and that can be directly activated (or inhibited) by interactions with metabolites. Building on my previous work studying metabolite-protein interactions using limited proteolysis, I will apply novel mass spectrometry-based proteomics approaches to investigate the gene expression allosterome. I will couple the measurement of structural changes caused by protein-metabolite interactions with their direct effects on chromatin accessibility and mRNA-protein associations. By measuring those effects in vivo, I will link allosteric interactions with gene expression activity. Finally, I will validate their functional role by integrating structural information with deep mutagenesis and cellular phenotyping in multiple environments. In summary, my research aims to establish a novel interdisciplinary approach to functionally characterize the complexity of the allosterome, to identify novel entry points for its modulation using small molecules and to refine our understanding of gene expression.

Keywords: allosterome,gene expression regulation,limited proteolysis coupled to mass spectrometry,metabolite binding domains,proteomics,protein metabolite interactions,chromatin
MikroMasch Powerstore for renewables microgeneration: scaling up the next generation battery technology for residential and commercial energy storage systems (POWERSTORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Estonia
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 1848150.0
EU funding (EUR): 1293705.0
Participants: 1
Project status: CLOSED

Currently, microgeneration is not an economical choice for most home- and business owners. Why? Because although the equipment costs are falling, the battery systems that are needed for using microgenerated power as the primary energy source offer only meager storage capacity at very high prices, leaving end consumers with 10+ years before their small scale wind stations or solar panels start to pay off. Energy storage systems (ESS) are the key enablers for adopting more renewables and demand-response grid solutions in the overall electricity supply mix. We are introducing the first ESS able to store enough energy to justify the investment in these solutions for home- and business owners. With our exceptional 50 kWh energy storage capacity per single system at very low charging cycle cost, we are the clear industry leader in the up and coming ESS market – our next generation POWERSTORE stores 7 times more energy at 8 times lower lifetime cost compared to state of the art technologies. ESS market is very attractive for investors and large Li-ion vendors alike, and is estimated to reach €14,6 billion by 2024. As our core innovation lies in the battery component level, the proposed technology is highly scalable and will potentially take the entire Li-ion industry to the next level of battery performance. Our concept is based on synthesizing unique composite nanomaterials that we use for coating Li-ion battery electrodes. The coating enhances battery specific parameters and prevents capacity degradation. Building upon our successful Phase 1 project, within the Phase 2 we will focus on the final technical optimisation of our electrode coating technology, ramp up our operations to a pilot scale, and prepare for market entry by piloting our technology in commercial ESS prototypes in collaboration with a large Li-ion manufacturer. Based on conservative estimates, we foresee realizing €46,8 million in estimated revenues by 2024.

Keywords: li ion battery,lnmc,energy storage systems,microgeneration,renewables,heat and power,grid smoothing,energy storage capacity,pilot demonstration
Development of novel and cost effective corrosion resistant coatings for high temperature geothermal applications (Geo-Coat)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Iceland,Romania,Norway,United Kingdom,United Kingdom,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2017-RES-RIA-TwoStage, 2017)
Start date: 2018-02-01
End date: 2021-05-31
Duration (months): 40.0
Total project cost (EUR): 4722722.5
EU funding (EUR): 4722722.5
Participants: 11
Project status: CLOSED

The Geo-coat project has been specified as necessary by our geothermal power and equipment manufacturing members, who, in order to reliably provide energy, need to improve plant capability to withstand corrosion, erosion and scaling from geofluids, to maintain the equipment up-time and generation efficiency. Additionally they need to be able to produce better geothermal power plant equipment protection design concepts through virtual prototyping to meet the increasing requirements for life cycle costs, environmental impacts and end-of-life considerations. Current materials, transferred from oil and gas applications to these exceptionally harsh environments, (and the corresponding design models) are not capable of performing, leading to constant need to inspect and repair damage. The Geo-coat project will develop new resistant materials in the form of high performance coatings of novel targeted "High Entropy Alloys" and Cermets, thermally applied to the key specified vulnerable process stages (components in turbines, valves, pumps, heat exchangers and pipe bends) in response to the specific corrosion and erosion forces we find at each point. We will also capture the underlying principles of the material resistance, to proactively design the equipment for performance while minimising overall capex costs from these expensive materials. The Geo-coat consortium has user members from geothermal plant operations and equipment manufacture to ensure the project's focus on real-world issues, coupled with world-leading experience in the development of materials, protective coatings and their application to harsh environments. In addition to developing the new coating materials and techniques, we also aim to transfer our experiences from the development of Flow Assurance schemes for Oil&Gas and Chemical industries to provide a new overarching set of design paradigms and generate an underpinning Knowledge Based System.

Keywords: high entropy alloy,cermet,hvof,laser cladding,corrosion,erosion,geothermal materials,knowledge based engineering