Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable industrial processes based on a C-C bond-forming enzyme platform (CARBAZYMES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Germany,Spain,Spain,Germany,Croatia,Netherlands,Netherlands,United Kingdom
Call: Widening industrial application of enzymatic processes (H2020-LEIT-BIO-2014-1, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 9251355.0
EU funding (EUR): 8202966.0
Participants: 15
Project status: CLOSED

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

Keywords: c c bond forming enzymes,lyases,aldolases,halohydrin dehalogenases,enzyme engineering,enzyme panels,thermostabilization,microreactor,technical scale,cascade reactions,apis,bulk chemicals
Cosmological Structure Formation in the Multiverse (COSFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 2191778.0
EU funding (EUR): 2191778.0
Participants: 1
Project status: CLOSED

This application proposes a programme of research directed at the outstanding puzzle of modern cosmology: the strangely small non-zero value of the vacuum density. This can be approached in three ways: (1) Evolution; (2) Revision of gravity;(3) Observer selection in the multiverse. The first two of these can be addressed by ongoing and future large galaxy surveys. Part of the research programme is directed at new ways of assuring robust measurements from these surveys of the main diagnostics of interest -- the effective equation of state of dark energy and the growth rate of density fluctuations. This will exploit and extend current work on systematics of galaxy properties as a function of large-scale environment in the cosmic web. But so far such tests show no deviation from standard gravity and a cosmological constant. This fact drives interest in a multiverse solution, in which different causally disconnected domains may be able to possess different effective cosmological constants. This research will concentrate on the astrophysically interesting question of how galaxy formation would be affected by different levels of vacuum energy. This previously been addressed only by oversimplified analytic arguments, and it is possible that the exponential sensitivity of galaxy formation efficiency to the vacuum density could be very different to the simple estimates. Current claims that the multiverse approach predicts the right level for the cosmological constant would then be disproved. In any case, there is much of interest to be learned regarding the robustness of current theories of galaxy formation by 'stress-testing' them outside the rather restricted parameter regimes normally considered. The result will be a deeper understanding of the assembly of cosmic structure in our universe, as well as indications of how it might have proceeded in other members of an ensemble.
Sustainable energy Positive & zero cARbon CommunitieS (SPARCs)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Ukraine,Germany,Iceland,Germany,Italy,Germany,Cyprus,Finland,Belgium,Finland,Finland,Greece,Czechia,Czechia,Portugal,Portugal
Call: Smart Cities and Communities (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 23852310.0
EU funding (EUR): 19701216.0
Participants: 36
Project status: SIGNED

Sustainable energy Positive & zero cARbon CommunitieS demonstrates and validates technically and socio-economically viable and replicable, innovative solutions for rolling out smart, integrated positive energy systems for the transition to a citizen centred zero carbon & resource efficient economy. SPARCS facilitates the participation of buildings to the energy market enabling new services and a virtual power plant concept, creating VirtualPositiveEnergy communities as energy democratic playground (positive energy districts can exchange energy with energy entities located outside the district). Seven cities will demonstrate 100+ actions turning buildings, blocks, and districts into energy prosumers. Impacts span economic growth, improved quality of life, and environmental benefits towards the EC policy framework for climate and energy, the SET plan and UN Sustainable Development goals. SPARCS co-creation brings together citizens, companies, research organizations, city planning and decision-making entities, transforming cities to carbon-free inclusive communities. Lighthouse cities Espoo (FI) and Leipzig (DE) implement large demonstrations. Fellow cities Reykjavik (IS), Maia (PT), Lviv (UA), Kifissia (EL) and Kladno (CZ) prepare replication with hands-on feasibility studies. SPARCs identifies bankable actions to accelerate market uptake, pioneers innovative, exploitable governance and business models boosting the transformation processes, joint procurement procedures and citizen engaging mechanisms in an overarching city planning instrument toward the bold City Vision 2050. SPARCS engages 30 partners from 8 EU Member States (FI, DE, PT, CY, EL, BE, CZ, IT) and 2 non-EU countries (UA, IS), representing key stakeholders within the value chain of urban challenges and smart, sustainable cities bringing together three distinct but also overlapping knowledge areas: (i) City Energy Systems, (ii) ICT and Interoperability, (iii) Business Innovation and Market Knowledge.

Keywords: solar thermal plant,phase change material,geothermal,distributed pv,energy behaviours,user centred energy system,bi directional ev charging,2nd life battery,peer to peer energy transactions
Shifting perspectives: from macrophyte collapses (tipping element) to global environmental change mitigation agents (SHIFT2SOLVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Environmental conditions in the Anthropocene are rapidly changing triggering important ecological shifts in the Earth system and approaching tipping-point levels faster than previously expected. Macrophytes are an important tipping element in the ocean, disproportionally contributing to climate regulation and in under global decline given the coexistence of multiple anthropogenic impacts. To date, most of the studies on macrophytes have focused on understanding their performance in relation to certain disturbances, but still few information exists about their overall capacity to mitigate global environmental change and their capacity to continue doing so in the future. This interdisciplinary project (SHIFT2SOLVE) comes timely at this aim addressing societal priorities for climate action and the efficiency of natural resources. The main objectives of the action are: 1) quantifying macrophytes’ capacity to buffer environmental change, 2) assessing macrophytes acclimatization and adaptive capacity, 3) forecast the resilience and mitigation capacity of macrophytes in the future based on IPCC climate scenarios and 4) use Unmanned Aerial Vehicles and machine learning to early identify ecosystem contractions at a landscape scale. These objectives will be accomplished by mixing surveys along natural gradients of temperature and ocean acidification (i.e. latitudinal gradients in the Western Mediterranean and natural CO2 vents), manipulative experiments in the field and in the laboratory, genetic analyses and mechanistic mathematical models based on ecophysiological processes. This project will importantly contribute to my career development and professional maturity increasing my independence as a researcher and the oportunities to continuing my research in Europe. Overall, the outcomes of the project will contribute to securing the maximum mitigation capacity possible associated with marine macrophytes, essential to preserve the resilience of the Earth System.

Keywords: resilience,tipping points,global environmental change mitigation,adaptation,macrophytes
Deciphering causes and consequences of inflammation in subtypes of sporadic intestinal cancer (DSMT16)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-15
End date: 2020-02-14
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

An association between inflammation and carcinogenesis is well established, however, how they are related mechanistically in subtypes of sporadic intestinal tumours remains unclear. This study aims to decipher how oncogenes determine the inflammatory microenvironment (stroma) and how this affects tumour development and survival. Notably, intestinal epithelium-specific expression of oncogenic Kras(G12D), Braf(V637E) and Pik3ca(H1047R) in mice mimics serrated intestinal cancers in humans faithfully. Preliminary data suggest that the mutational make-up of the tumour may dictate the pro- and anti-tumourigenic immune response, which in turn determines tumour development and survival. This study therefore aims to characterise the tumour-infiltrating immune cells by systematic immunophenotyping and to decipher the involved inflammatory signalling mechanisms in a cell-type and mutation-specific manner. Moreover, we aim to reconstruct the formation of the oncogene-specific inflammatory microenvironment, which we will determine via endoscopic transplantation of intestinal organoids derived from Kras(G12D), Braf(V637E) and Pik3ca(H1047R) mice into the large intestine of wild-type mice. Importantly, detection of involved inflammatory mediators and immune cell-subtypes will allow us to genetically target them in vivo using novel in-house generated dual-recombinase systems (DRS). In order to investigate the consequences of inflammation on sporadic intestinal tumourigenesis, models with genetically or experimentally induced chronic inflammation will be applied. Conversely, immunodeficient Rag2;Il2rg–/– mice will be used to elucidate if sporadic intestinal carcinogenesis in Kras(G12D), Braf(V637E) and Pik3ca(H1047R) mice is dependent on inflammation and can be abrogated. This study will generate new mechanistic insights into the microenvironment of cancer subtypes, which could provide a basis for the development of new personalised immune therapies.

Keywords: signal transduction,oncogene induced inflammation,tumour microenvironment stroma,transgenic mouse models,cancer disease models
Harnessing Targeted Nanotheranostics to Reprogram Activated Leukocytes in Inflammatory Bowel Disease (LeukoTheranostics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel,United States
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 2703125.0
EU funding (EUR): 2527608.0
Participants: 2
Project status: CLOSED

Inflammatory bowel diseases (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn’s disease (CD) and Ulcerative Colitis (UC) that can impact both the large and small bowel. IBD affects approximately 3.7 million Europeans and its peak onset is in persons of 15 to 30 years of age. IBD imposes a significant burden on Europe with over €3B in annual health care costs and over €3B in indirect cost. The prevalence of IBD is expected to increase by more than 40% over the next decade in many European countries. Therefore, to meet the needs of IBD patients in the European community, we must prepare for the evolving landscape of IBD care in the near future. Although its etiology remains unknown, unregulated immune cells are implicated in the pathogenesis of IBD. As many IBD patients are refractory to conventional medical treatments, there is an urgent need to develop novel therapeutic modalities in combination with real-time imaging in order to manage the disease. I will achieve this goal by generating a "Trojan horse" strategy of targeting activated leukocytes that home to the gut in IBD rodent models and reprogram their fate using RNA interference (RNAi) combined with molecular imaging. The primary objective of this proposal is to reprogram in vivo activated leukocytes involved in gut inflammation using advanced RNAi-based therapeutics combined with molecular imaging strategies as the first theranostic modality utilizing leukocytes. The following specific aims include: (i) To develop and characterize unique integrin-targeted nanoparticles (I-tsNPs) targeting a high-affinity (HA) conformation of a4b7 integrin expressed on gut leukocytes; (ii) To study I-tsNPs 3-dimensional (3-D) delivery in colitis models using microPET/CT imaging; (iii) To investigate efficacy and safety profiles using the HA I-tsNPs platform for IBD therapeutics and disease management that will lay the foundation for future clinical trials.

Keywords: sirna,nanomedicine,leukocytes,integrins
Epistasis analysis of angiogenes with high cellular definition (AngioGenesHD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1481375.0
EU funding (EUR): 1481375.0
Participants: 1
Project status: CLOSED

Blood and lymphatic vessels have been the subject of intense investigation due to their important role in cancer development and in cardiovascular diseases. The significant advance in the methods used to modify and analyse gene function have allowed us to obtain a much better understanding of the molecular mechanisms involved in the regulation of the biology of blood vessels. However, there are two key aspects that significantly diminish our capacity to understand the function of gene networks and their intersections in vivo. One is the long time that is usually required to generate a given double mutant vertebrate tissue, and the other is the lack of single-cell genetic and phenotypic resolution. We have recently performed an in vivo comparative transcriptome analysis of highly angiogenic endothelial cells experiencing different VEGF and Notch signalling levels. These are two of the most important molecular mechanisms required for the adequate differentiation, proliferation and sprouting of endothelial cells. Using the information generated from this analysis, the overall aim of the proposed project is to characterize the vascular function of some of the previously identified genes and determine how they functionally interact with these two signalling pathways. We propose to use novel inducible genetic tools that will allow us to generate a spatially and temporally regulated fluorescent cell mosaic matrix for quantitative analysis. This will enable us to analyse with unprecedented speed and resolution the function of several different genes simultaneously, during vascular development, homeostasis or associated diseases. Understanding the genetic epistatic interactions that control the differentiation and behaviour of endothelial cells, in different contexts, and with high cellular definition, has the potential to unveil new mechanisms with high biological and therapeutic relevance.

Keywords: angiogenesis,vascular biology,notch,vegf,development
ASSESSING THE IMPACT PATHWAYS OF IA/RIA SC5 PROJECTS THROUGH THE USE OF PORTFOLIO ANALYSIS (IMPACT-SC5)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Coordination and support actions
Countries involved: Spain,Belgium,Finland,Greece
Call: Assessing and fostering the impacts of Research and Innovation Actions (RIA) and Innovation Actions (IA) granted by Societal Challenge 5 in 2014-2015 (H2020-SC5-2019-1, 2019)
Start date: 2019-11-01
End date: 2021-06-30
Duration (months): 20.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 4
Project status: CLOSED

The project IMPACT-SC5 aims to assess the impacts of the 87 funded RIAs and IAs, through a multilevel analysis, starting at project (participant) level, via portfolio, network and context analyses. It applies a rigorous methodology that enables to capture the various (intended and unintended) impacts of projects and groups of projects. Horizon 2020 contributes, via its focus on ‘Societal Challenges’ (SCs), to the ongoing paradigm change in Research and Innovation Policy. The pursued objectives are not only to generate economic growth and jobs, but to help resolve pressing socio-economic challenges, including those related to climate, environment, resource efficiency, and raw materials (SC5). The challenge orientation of H2020 implies monitoring the progress of the projects towards the achievement of the targeted objectives and impacts. The scientific, economic and societal/environmental performance of the 87 RIA and IA projects under the SC5 Work Programme 2014-15 will be measured by means of an extensive set of indicators. A portfolio analysis will complement the project-level analysis in order to determine how projects perform together in relation to different objectives. IMPACT-SC5 explores impact pathways to identify good practices and draw recommendations for policymakers and potential EU research funding beneficiaries to increase the impacts of future SC5 projects. Particular attention is paid to the broad and changing policy contexts to ensure a holistic approach for a better understanding of the performance (and the underlying factors) of the 87 projects. Throughout the project, stakeholder engagement will be strongly fostered. The methodology and findings (including the recommendation) will be validated with high-level experts and practitioners who will also be channels for dissemination. The methodology will be made available to the European Commission for its use in the ex-post evaluation of H2020 or future evaluation exercises.

Keywords: portfolio analysis,impact pathways,innovation action,research innovation action,socio economic impact,climate action,raw materials,environment,resources efficiency