Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Phase separation in Alzheimer's disease and Phase-separated c-Abl dynamics (PhaSeAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Neurodegenerative diseases like Alzheimer's disease (AD) are a major global health concern, affecting millions and placing significant economic burdens on healthcare systems. Despite advancements in understanding AD pathogenesis, effective treatments remain elusive. PhaSeAD (Phase separation in Alzheimer's disease and Phase-separated c-Abl dynamics) aims to explore the role of the c-Abl protein kinase in AD pathogenesis, focusing on its interaction with liquid-liquid phase separation (LLPS). Objectives include understanding c-Abl phosphorylation specificity using NMR spectroscopy to study its interaction with substrates Tau and PSD-95, providing insights into c-Abl's substrate specificity and phosphorylation selectivity. Additionally, we will explore c-Abl function within LLPS droplets using biochemical assays like ITC and kinase assays to assess its activity inside and outside LLPS droplets. Fluorescence microscopy techniques like FRAP and FCS will visualize and quantify c-Abl dynamics within LLPS droplets and its interaction with other LLPS components. Furthermore, we will investigate the role of c-Abl and LLPS in regulating cytoskeletal dynamics, crucial for neuronal function and disrupted in AD. High-resolution microscopy techniques, including super-resolution and electron microscopy, will visualize and quantify the impact of c-Abl and LLPS on cytoskeletal assembly and organization. Live-cell imaging techniques will assess their impact on neuronal morphology and function. Expected outcomes include a comprehensive understanding of c-Abl's behavior within LLPS droplets, its impact on Tau and PSD-95 phosphorylation, and its regulatory role in cytoskeletal homeostasis. These findings will enhance our understanding of c-Abl's involvement in AD pathogenesis and may lead to novel therapeutic targets for developing effective treatments for AD and other neurodegenerative diseases.

Keywords: protein kinase,structural dynamics,liquid liquid phase separation,cytoskeleton homeostasis
Selective ethylene oxidation on novel curved model catalysts (CURVEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Heterogeneous catalysis has made a wide range of highly functionalized materials available to us and therefore is an important contributor to economy and society. Ethylene epoxidation is a keystone process of the chemical industry, because it produces one of the building block chemicals, ethylene oxide, from which a range of high-value chemicals can be manufactured. However, product formation competes with complete combustion to CO2, and the process is nowadays the largest CO2 emitter of the European industry. The reaction mechanisms that lead to either EO or CO2 formation, as well as the role of the catalytic surface, are still not determined. The project will implement a new approach to study the mechanism of ethylene oxidation under realistic reaction conditions, while making use of surface-sensitive and atomically accurate techniques. We will employ curved single crystals with tuneable surface structures as model catalysts to unveil site-specific reaction pathways for ethylene oxidation under both UHV and reaction conditions. We will explore the formation of different intermediate species, and determine the selectivity of the ethylene oxidation reaction. This approach significantly exceeds the current state-of-the-art, setting a new paradigm for the understanding of catalytic systems. The impact on academic research and industrial applications will be substantial.

Keywords: operando catalysis near ambient pressure xps selective oxidation novel model catalysts structure sensitivity
Human Genomics without Racism (HUGERA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499979.0
EU funding (EUR): 1499979.0
Participants: 1
Project status: SIGNED

How can we study human genomics without racism? This project will develop an empirically informed philosophical framework to answer this question. The project aims to produce a systematic diagnosis of how racism can influence human genomics research, identifying the types of harm that unfold from it but might have been overlooked by scientists. Human Genomics promises to reveal who we are and revolutionize medical diagnosis and treatment. However, geneticists and social scientists are increasingly worried that genomics research might involve racist assumptions, unknowingly harming vulnerable populations. It is key to assess how racism might co-opt Human Genomics and how harmful it is, but key knowledge gaps persist. For instance, discussions about racism in Human Genomics are rarely grounded on theories of racism. These discussions focus on parts of the research ecosystem (e.g., data collection) and don’t consider how racism can influence the whole knowledge production process. The project aims to fill this knowledge gap by combining the conceptual apparatus developed by philosophers of science and race with empirical, qualitative methods from the social sciences. First, we develop an epistemological account of two key methodologies in human genomics research, characterizing how data, models, theories, and experiments interrelate to generate genetic knowledge. Second, we conduct a multidisciplinary literature review and interviews to identify potential racist assumptions in those methodologies of human genomics research, analysing them in light of theories of racism. Third, we examine the role of those assumptions in the generation of genetic knowledge, identifying the types of epistemic injustice that follow from it and how they are overlooked by scientists. Our results will help scientists identify aspects of genetic research that require ethical attention to avoid racism.

Keywords: racism human genetics classification ethics of science epistemology genome wide association studies
LUMI AI Factory - Advanced experimental AI-optimised quantum based platform (LUMI-IQ)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Finland,Czechia,Norway,Poland
Call: Advanced Experimental AI-optimised Supercomputing Platform (HORIZON-JU-EUROHPC-2025-AI-01-IBA, 2025)
Start date: 2025-05-01
End date: 2032-04-30
Duration (months): 84.0
Total project cost (EUR): 40000000.0
EU funding (EUR): 20000000.0
Participants: 4
Project status: SIGNED

As AI technologies and methodologies continue to advance swiftly, Europe has been actively developing and strengthening the ecosystem of frameworks, environments, tools and services required to boost innovation. This comprehensive approach aims to harmonise AI strategies across the continent, addressing the technology’s challenges and opportunities, while assessing its impact on public and private sectors, and society at large. Leveraging the ongoing momentum and LUMI’s successful history, the Finland led consortium responds to the HORIZON-JU-EUROHPC-2025-AI-01-IBA-02 call by introducing the LUMI AI Factory - Advanced experimental AI-optimised quantum based platform or LUMI-IQ, part of the broader LUMI AI Factory ecosystem, to be procured and installed together with the LUMI-AI supercomputer and leveraging the LUMI AI Factory Service Center.

Keywords: artificial intelligence,quantum computing,ai optimised supercomputer,experimental platform,ai factory
Digital worlds enabling real impact on safety, quality and sustainability (RISQS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Flasheye develops world-leading perception software for 3D sensors. Our vision is to unlock the opportunity to use these new high-capacity sensors in every unique environment, installable by anyone, and on a larger scale. The LiDAR technology has been most used for self-driving cars and robots but unlike traditional mobile applications, we focus on stationary 3D monitoring to make the infrastructure intelligent and autonomous. Our mission is to close the gap between new 3D sensing technology and practical usability by offering intuitive 3D software that delivers human-like perception of the world. Our solution captures every movement and deviation in real-time, enabling immediate responses and significantly enhancing situational awareness. By continuously collecting and analyzing data from the real-time monitoring, our software drives long-term optimization of systems and operations, fostering innovation and efficiency across all applications. The sensors from the manufacturers only generate raw data that are not actionable. With spatial perception and human-like understanding at its core, our solution is essential to make operations safer and more autonomous across various sectors. Our perception technology leverages reliable and spatially precise 3D data to automatically control machines and alert in dangerous situations or potential breakdowns through superior situational awareness. This minimizes errors and unexpected stops to almost zero. With our resilient monitoring systems, human presence in hazardous environments becomes unnecessary, as operators can safely oversee operations from a distance with more accurate and comprehensive information. This allows clients to actively pursue automation and autonomy—maximizing efficiency and precision— while meeting safety, security, and sustainability goals. The vision is to be present on the global market and in 2028 reach a turnover of €12 million, a company valuation of € 50 million and 50 employees.

Keywords: autonomous systems,perception software,automation
A Flexible Strategy for Stapling and De-Stapling of Unprotected Peptides (STAPLE-De-STAPLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Cyclic (stapled) peptides often possess superior biological activity compared to their linear counterparts and are more attractive leads in drug development. This is for several reasons: conformational rigidity (enhanced binding to target molecules and receptor selectivity), resistance to degradation by peptidases (increased stability and potency), and greater cell permeability. Reliable strategies for peptide stapling are therefore in high demand, especially if cyclizations are reversible under certain controllable conditions. The reason is that a linear peptide can be biologically more active. If de-stapling can be triggered by an intracellular signal, then once the cyclic peptide has entered the cytosol, it can be converted to its more active acyclic form. We propose to develop a robust, practical, and broadly applicable catalytic method for stabling of peptides. Cyclizations, which will be promoted by inexpensive and easily available Cu(I) catalysts, are inspired by recent findings by the host group in Strasbourg. The Hoveyda group has shown that a highly functional group tolerant catalytic click reaction can be used to link a drug-bound allene to a ketone that is bound to unprotected penetratin, a cell-penetrating peptide (CPP). The process was completed in just 3-5 hours in aqueous media and at ambient temperature. Also inspired by the recent discoveries in the host group, de-stapling will be triggered by a reactive oxygen species (ROS) and specifically H2O2, higher concentration of which have been shown to signal the onset of diseases such as cancer and diabetes. The results of these studies are expected to have an immediate impact on catalytic chemical synthesis, aiding in the elucidation of biological mechanisms and accelerating drug development and discovery. Additionally, the proposed work will significantly contribute to environmentally responsible and green chemistry, aligning with the EU sustainable development strategy.

Keywords: stapled peptides,cu catalyzed click chemistry for peptide stapling,reversible peptide stapling,oxidant triggered peptide de stapling
Primordial Germ Cells Environmentally-driven fate in Zebrafish (PEZ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

In a global climate change scenario with pieces of evidence of abiotic factor changes and the increase of pollutants due to anthropogenic activities, we are starting to accumulate evidence of its effects on animal welfare and physiology. One of these effects is changes in fish sex determination and differentiation processes due to alterations of abiotic and anthropogenic factors. Among these factors, temperature is known to affect sex determination well before the gonads are differentiated, pointing towards an evident interplay between the genetic and environmental factors, even prior to gonad formation at the primordial germ cell (PGCs) stage. However, how temperature controls PGCs and final sex ratios fate is still unknown. In this project, I aim to dissect when and how temperature is controlling the fate of PGCs. Hence, driving the future sex ratio of the population since changes in sex ratios could put at risk future food production and species conservation. To that extent, I propose combining state-of-the-art imaging, genomic, and epigenetic technologies to analyse PGCs transcriptomic and epigenetic landscapes of zebrafish under thermal stress. This project capitalises on combining my background in epigenetics and bioinformatic fields with extensive expertise in developmental biology, fish sex determination and differentiation and spatial transcriptomics of the host labs. This multidisciplinary proposal will explain how temperature increases as predicted on a climate change scenario modulates PGCs fate and identity. These results will significantly advance the field of epigenetics and developmental biology and will impact future food production and species conservation. Finally, the knowledge and skills gained from this project will allow me to become an independent researcher and hopefully enable me to establish my own line of research in Regulatory Genomics applied to aquaculture and marine conservation.

Keywords: primordial germ cells pgcs,climate change,gonad formation,gonad differentiation,sex ratio
EU-Africa Research Infrastructure Alliance to Foster Infectious Disease research, Knowledge sharing and Innovation (RAFIKI)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,South Africa,United Kingdom,Ghana,Kenya,Zambia,Switzerland
Call: Strengthen the bilateral cooperation on research infrastructures with Africa (HORIZON-INFRA-2024-DEV-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 1499981.3
EU funding (EUR): 1499981.3
Participants: 9
Project status: SIGNED

The RAFIKI consortium will support capacity building for early drug discovery in Africa with a focus on infectious diseases (e.g., malaria, tuberculosis). Sub-Saharan Africa is disproportionately burdened by such diseases yet lacks a critical mass of appropriately skilled scientists and access to general infrastructure, enabling technology platforms and expertise for drug discovery research. RAFIKI will leverage existing collaborations within the consortium to build the knowledge and technical capacities of research institutions across Africa. RAFIKI will establish regional training hubs in South, East and West Africa to support local capacity/skillset building for early-/mid-career researchers via bidirectional scientific training visits, mentorships, regional in-person workshops and online training courses. To establish the requisite infrastructure for future drug discovery R&I, knowledge and procedures will be shared for compound library curation at partner institutions (i.e., workflows, open database creation, library sharing capabilities), and data management capacities will be bolstered using the Collaborative Drug Discovery (CDD) Vault. To secure funding beyond the project lifetime, the consortium will liaise with relevant industrial actors and potential public/private funders.

Keywords: drug discovery,research infrastructures,infectious diseases,capacity building,eu african collaboration
Populism and institutions in Latin America. A comparative assessment between Ecuador and Argentina (POPINLAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Ecuador,Argentina
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 260939.52
EU funding (EUR): 260939.52
Participants: 4
Project status: SIGNED

POPINLAT scrutinises the oft-contested and under-theorised relationship between populism and institutions through a comparative analysis of the recent left-of-centre processes in Ecuador (2007-2017) and Argentina (2003-2015). This research innovatively brings into the analysis also the post-populist phase in order to assess the resilience and embeddedness of the institutionality left behind by the populist rule (2017-2020 and 2015-2019, respectively) and, as a result, allows to theorise on the possibility and conditions of emergence of a "republican populism". In this sense, the current moment is particularly well-suited to carry out the proposed research. POPINLAT is situated at the crossroads of different disciplines, namely political theory, comparative politics and institutional analysis, thus using and integrating diverse methodologies. POPINLAT will be based at the University of Venice Ca’ Foscari, with the outgoing phase taking place at the Facultad Latinoamericana de Ciencias Sociales FLACSO-Ecuador in Quito. It also envisages a secondment at the Universidad de Buenos Aires (UBA) and a short stay at the National University of La Matanza, in the province of Buenos Aires. By looking at the institutional merits and shortcomings of the two cases, the project will cast light on the Latin American pink tide as a whole, and more importantly, provide a novel approach in populism studies, which can be applied to the European case as well. Having an excellent competence in populism and discourse analysis, and having worked in the Ecuadorian institutions during the period under scrutiny, I think of being in a favourable position to successfully complete this research and obtain professional maturity so as to become a leading academic in the field of populism studies.

Keywords: populism,latin american politics,left radicalism,hegemony,republicanism,institutions
First-in-human flexible array implant to restore vision (FLAIRVISION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,Spain,Hungary
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2906004.86
EU funding (EUR): 2495144.15
Participants: 4
Project status: SIGNED

This project aims at a pivotal advancement towards a long-standing promise of science and technology: a visual prosthesis that restores useful levels of vision to blind people. It combines results from two earlier EU funded projects: In NeuraViPeR, Fernandez et al. implanted a small needle-bed shaped silicon electrode array in the visual cortex of blind volunteers. Electrical microstimulation on this silicon array was able to induce the percept of simple shapes directly to the blind person, and also enabling her to find boundaries of objects. However, as most of the visual cortex does not lie on the surface of the brain, this cannot be readily upscaled to practical levels. In HyperStim, we developed a technology to build flexible, polymer-based electrode arrays that can be shaped to address the entire primary visual cortex. In tests on rhesus monkeys, we have proven durability of the electrode arrays over several years, vastly improved tissue integration and reduced scar tissue formation compared to the earlier silicon probe technology, and to current clinically used electrode arrays. Furthermore, we have proven the ability to increase the resolution beyond the number of electrodes that are physically present by using advanced stimulation patterns. In the current proposal, we will combine the two previous projects and prove in a first-in-human experiment in a blind patient that this is indeed the way forward to restore a level of vision that is useful in daily life. In terms of business development, we have already founded a start-up company around this concept and raised seed funding. We have 3 pending patents. The project's business objectives revolve around further advancing the company in terms of business plan, quality systems, documentation and IP. Combining these business objectives with success in the aforementioned research goals will help us reach our ambitious final goal: to successfully raise series A funding by the end of the project.

Keywords: blindness,cortical prosthesis,microstimulation,electrode