Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LASER FOR MASS PRODUCTION OF FUNCTIONALISED METALLIC SURFACES (LASER4SURF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Ireland,Belgium,Belgium,France
Call: New product functionalities through advanced surface manufacturing processes for mass production (H2020-FOF-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 4077750.0
EU funding (EUR): 4077750.0
Participants: 13
Project status: CLOSED

The main goal of the LASER4SURF project is to develop a laser based solution for the functionalization of metallic surfaces with textures ~1µm or less on mass production. This solution will be based on surface functionalization with ultrashort pulses via Laser Induced Periodic Surface Structures (LIPSS). The LASER4SURF project will develop a Laser Texturing Prototype to overcome the current barriers for the LIPSS technique to reach mass production, achieving a production rate of 0.1 min/cm2: • High process time for large 3D pieces. • Need of inline inspection methods. • Need of modelling tools for parameter selection. The development will be focused on the three main steps of the Laser texturing value chain: • Laser technology/equipment. To generate LIPSS of different pattern sizes with multiple orientations, LASER4SURF will develop an easy to integrate and control, compact and low cost optical module. • In-line inspection tool. A whole optical measurement system based on diffractometry technology will be integrate with the laser equipment including hardware and software in order to be able to monitor all different nano properties from the functionalised surfaces. • Simulation tool that will show automatically the process parameters required to obtain the desired functionality for a specific material. The simulation tool will automatically transfer the optimum laser parameters to the LIPSS equipment in order to configure it for the desired pattern. The project will combine the developments in an all in one solution, that will be validated by three different use case products that represent a broad range of the main industries, metal alloys used and required functionalities. The LASER4SURF project will be developed by a well-balanced consortium that brings together 8 partners: 3 technology developers (CEIT, MULTITELL and VISUM), an integrator of the solutions (LASEA), three industrial partners (FAGOR, RESCOLL and CIC) and a dissemination partner (ESCI)

Keywords: lipps,laser,femtoseconds,functionalisation
A multi-disciplinary international effort to identify clinical, molecular and social factors impacting cutaneous leishmaniasis (LeiSHield-MATI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Algeria,Iran, Islamic Republic of,Belgium,Sweden,Tunisia,France,France,France,Czechia,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 1750500.0
EU funding (EUR): 1750500.0
Participants: 11
Project status: SIGNED

Leishmania causes devastating human diseases – leishmaniases - representing an important public health problem in the Mediterranean basin and declared as emerging diseases in the EU due to climate change and population displacement. The LeiSHield-MATI consortium will for the first time investigate in an integrative fashion the complex parasite-vector-host interplay in cutaneous leishmaniasis affecting Morrocco, Algeria, Tunisia, and Iran (MATI), using field isolates and human clinical samples. The ultimate goal of our project is to identify genetic factors selected during natural infection and to understand how the complex parasite-vector-animal interaction impacts clinical outcome in infected patients. This goal will be achieved through a highly ambitious secondment plan between all partners, and the organization of courses and workshops to train the next generation of scientists generating a long-term impact on the research capacities in endemic areas. Capitalizing on complementary infrastructures of its EU, African and Asian partners and their expertise in molecular parasitology, epidemiology, systems level analyses, bioinformatics, computational biology, immunology, dermatology, field studies, and public health, our project will drive important innovation in clinical research, strengthen capacities in disease endemic regions, inform authorities on control measures, and raise awareness in all partner countries on this emerging EU public health problem. The highly inter-disciplinary and inter-sectorial structure of LeiSHield-MATI, and its powerful integrative and comparative approach is novel in parasitic systems and will drive a unique bio-marker discovery pipeline for the future development of new prognostic and diagnostic tools, as well as novel preventive and therapeutic measures that will ensure long-term collaboration, promote scientific and commercial self-sustainability of its partners, and will have an important impact to improve public health.

Keywords: leishmanioses,parasite vector host interaction,rnaseq,htseq,biomarkers,prognostic and diagnostic tools,cl psychological impact,immune response
Dusting for the Fingerprints of Planet Formation (DustPrints)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2023-06-30
Duration (months): 76.0
Total project cost (EUR): 1435088.0
EU funding (EUR): 1435088.0
Participants: 1
Project status: SIGNED

With close to 2000 detected planets, it is striking that we still do not understand how planets form. Their building blocks form in gas disks around young stars, where colliding dust grains form ever-larger aggregates. But this growth is not without limits: larger particles quickly drift towards the star and collide at speeds that shatter them to pieces, long before gravity can bind them together. The mechanisms involved in the assembly and transport of these building blocks remain some of the biggest mysteries of planet formation. Solids in protoplanetary disks evolve differently than the gas, but not independent of it. Observations allow us to directly probe particle growth – the first stage of planet formation. But the gas-solids coupling also enables us to probe the gas disk structure indirectly – just like we cannot see the wind, but we see leaves being moved by it. With this proposal I want to answer some of the key questions of planet formation: (1) What mechanisms drive disk evolution? (2) What role do solids play in the transport of volatiles and the pre-biotic building blocks of life? We will for the first time couple detailed models of the evolution of solids in protoplanetary disks with chemical models on the one side and with hydrodynamical simulations on the other. We aim to derive the unique observable fingerprints of these processes and link those predictions to upcoming observations. With the advent of the ALMA observatory, the prospects of finding these fingerprints are excellent. ALMA will allow us to test our predictions through a wide range of observables at unprecedented sensitivity and resolution, including dust continuum emission, chemical abundance patterns, and isotopic ratios in disks, comets, and our solar system. With our work designed to interpret these observations, we will set the stage for a future understanding of protoplanetary disks and planet formation.

Keywords: astrochemistry
Optimized Industrial HIPIMS system for coating Plastic Injection Moulds (HIPINDMOULD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In recent years an innovative magnetron sputtering technique named high power pulsed/impulse magnetron sputtering (HPPMS/HIPIMS) has emerged. It is characterized by a high degree of ionization of the sputtered material which makes it a very attractive deposition technique for enhancing and tailoring coating properties. Extremely dense, hard, well adherent and smooth coatings are obtained. However, after fourteen years of developments, the real up-scaling and industrialization of this promising technology has not been achieved. The main problem is the mistaken assumption based just on including new HIPIMS power supplies into conventional sputtering systems. This project aims to develop new HIPIMS deposition equipment capable to control process parameters (magnetic field strength and unbalance and pulsing configuration) in order to demonstrate that process-designed HIPIMS for specific application can result in superior coatings. The target market for the developed coatings is the plastic injection moulding sector where there are high demands on surface quality of moulds. The main degradation mechanisms involved are adhesion, abrasion and corrosion of the surface; moreover, low adhesion of the plastic melt is necessary for reduction of release forces. HIPIMS technology offers outstanding advantages with respect to conventional coating technologies currently applied on moulds (PVD and electroplating) offering optimized performance against corrosion, sticking and wear. This project gives FLUBETECH the opportunity to evaluate the requirements and benefits (both technical and economical) that the launch of an optimized concept of HIPIMS, repetitive and easy to scale-up, will entail for them. Phase 1 of this project will assess the technical feasibility and commercial potential of the breakthrough innovation that Flubetech wants to exploit and commercialize. The outcome of this study will be a detailed business plan.

Keywords: hipims,sputtering,magnetic field,pulse,hardness,adherence,smoothness,density,repetitivity,scale up,industrialization,feasibility,commercialization,market,competitor,business plan
Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome (GenEdiDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Neurodevelopmental disorders (ND) are chronic psychiatric conditions with different etiologies, but most share a strong genetic component, defective brain development, and cognitive impairment. Currently, treatment options are very limited, and early educational intervention is the cornerstone for the management of cognitive impairment in most ND, indicating the positive effect of early actions during brain development. Among ND, Down syndrome (DS) is caused by the presence of an extra chromosome 21, and it represents the leading cause of genetically-defined intellectual disability. Different pharmacological treatments targeting one of the many pathways downstream of the triplicated genes have been shown to rescue cognitive impairment in DS animal models. Nevertheless, most of these preclinical studies have been performed postnatally and often in adults, possibly because of concerns of unwanted drug side effects that may have long-lasting noxious sequelae on a developing brain at embryonic stages. On the other hand, viral (but also non-viral) gene therapy approaches in animal models of ND have been mostly neglected because of technical and ethical issues, when considered in the light of future translational applications. Yet, DS is mostly diagnosed prenatally, when many of its brain developmental abnormalities originate. Here, we will investigate whether in utero manipulation of specific and possibly converging gene networks in neuronal progenitors of DS mice by CRISPR-Cas9 gene-editing technology, may recover brain development and cognitive deficits later in life. Specifically targeting neuronal progenitors will allow us to act at early stages of brain development, while avoiding the involvement of genetic editing of germline cells and all related ethical issues. In parallel, we will also develop safer (viral-free) technological approaches for genetic manipulations in utero to minimize technical issues in the view of potential future translational applications.

Keywords: down syndrome,sonoporation electroporation,girk2,nkcc1,dyrk1a,gaba
New Directions in Lightweight Cryptanalysis (LightCrypt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

Over the next five years, fifty billion new smart devices will be connected to the Internet of Things (IoT), creating a revolution in the way we interact with our environment. Such resource constrained devices will require lightweight cryptography to protect them and us from bad actors. Unfortunately, such schemes can be highly vulnerable: Two notable examples are the encryption schemes used in GSM cellular phones and in car remote controls - both broken by the PI. We claim that it is not sufficient to adjust the current design and analysis tools to the constrained environment. Instead, we must establish a new research methodology, aiming directly at the problems arising in the 'lightweight realm'. We plan to concentrate on four main directions. First, we will go 'a level up' to study the security of generic lightweight building blocks in order to find the minimal number of operations required to transition from insecure to secure designs. Second, when considering specific ciphers we will pursue practical low complexity attacks, which are more relevant to the lightweight realm than standard theoretical attacks. Third, we will pursue new directions toward establishing 'white-box cryptography' – a central challenge in IoT cryptography. Finally, we will explore further applications of discrete analysis to lightweight cryptography, trying to establish rigorous conditions under which the standard cryptanalytic techniques apply in order to avoid unnecessarily pessimistic security estimates. For the near future, we hope that our research will make it possible to detect and fix weaknesses in existing lightweight ciphers before they can be exploited by the 'bad guys'. Looking forward farther, we hope to understand how to design new secure lightweight ciphers for the billions of IoT devices to come.

Keywords: cryptanalysis,lightweight cryptography,low complexity cryptanalysis,whitebox cryptography
Perfluorinated Organic Compounds (PFCs) Degradation using Non-Thermal Plasma Enhanced by Boron Doped Graphene Oxide as Catalyst (PFCsByPlasCat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-10-15
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

The extensive use of perfluorinated compounds (PFCs) in many industrial/commercial applications, as surfactants, emulsifiers, etc., and their high chemical stability are responsible for their ubiquitous presence in the environment. Specifically, the contamination of groundwater and drinking water supplies by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) is raising great concern as more data on PFCs toxicity in humans and wildlife is becoming available. Thus, a parallel surge in monitoring campaigns and in the search for innovative water treatment technologies for PFCs is required. Since PFCs are highly resistant to degradation by standard chemical and biological processes, advanced oxidation processes (AOPs) are being considered and, including Fenton, ozone and UV irradiation with catalysts, applied so far with limited success. Among innovative AOPs, air non-thermal plasmas (NTP), which produce several reactive species at a time, have been recently tested for the treatment of PFOA/PFOS yielding promising results. The proposed research aims to advance the state of art by developing an innovative treatment process for PFCs in which NTP is applied in combination with novel boron-doped graphene oxide (B-GO) nano photocatalysts. The catalysts synthesized and characterized by the Researcher will be tested on prepared solutions of PFOA and PFOS using various NTP reactors which are available in the beneficiary laboratory. The best catalyst-reactor combination will thus be identified; conditions and parameters will be optimized to maximize the synergy between plasma and catalyst and the efficiency of the novel hybrid plas-cat process. Real samples of contaminated groundwater will be tested to verify the process applicability to complex matrices. For excellence of research, basic guidelines will be drawn and disseminated for implementing an efficient hybrid plas-cat process in view of auspicable scaling-up and technology transfer to stakeholders.

Keywords: non thermal plasma,cold plasma,emerging organic pollutants,perfluorooctanesulfonate,perfluorooctanoic acid,advanced oxidation process aop,engineered nanoparticles,boron doped graphene oxide
Harnessing spinal electrical stimulation to modulate autonomic function after spinal cord injury (symESTIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Severe spinal cord injury (SCI) interrupts descending sympatho-excitatory axons responsible for cardiovascular control. Devoid of supraspinal input, sympathetic circuits within the spinal cord undergo significant plastic changes. These changes lead to a debilitating clinical scenario that includes frequent bouts of hypertension (autonomic dysreflexia) and orthostatic hypotension, conditions which have extremely limited treatment options and lead to increased risk for cardiovascular disease. Here, I propose to deconstruct the sympathetic circuitry within the spinal cord in order to develop a targeted electrical neuroprosthesis that prevents the development of these clinical conditions. To dissect the sympathetic circuitry that drives sympathetic dysfunction after SCI, I will deploy judicious associations of optogenetics, chemogenetics, calcium imaging, virus-mediated tract-tracing and whole brain-spinal cord imaging in transgenic rats. For example, the catecholaminergic specificity of TH:Cre rats will enable the visualization of the residual descending sympatho-excitatory axons following severe contusion SCI, and will provide specific access to splanchnic ganglia neurons. This understanding of the sympathetic circuitry will allow me to map the hemodynamic responses following electrical spinal cord stimulation to the modulation of specific circuits and connections. This knowledge will then guide the development of a tailored neuroprosthesis targeting these circuits in order to regulate sympathetic dysfunction after SCI. Finally, I will exploit this neuroprosthesis to rehabilitate the sympathetic system after SCI, which I will demonstrate with longitudinal functional assessments and detailed anatomical evaluations. My ultimate goal is to develop targeted autonomic neurorehabilitation—a novel method to treat autonomic dysfunction after SCI that will improve the quality of life of those suffering from this condition.

Keywords: spinal cord injury,autonomic nervous system