Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CENTER OF INNOVATIVE SOLUTIONS FOR BUILDING SAFETY – ISTOS Center of Excellence (ISTOS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Cyprus,Greece
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-11-01
End date: 2024-04-30
Duration (months): 42.0
Total project cost (EUR): 901875.0
EU funding (EUR): 900000.0
Participants: 4
Project status: SIGNED

Europe is experiencing an increasing number of disasters due to natural hazards. The potential for a hazard to cause a disaster mainly depends on the vulnerability of the exposed community to a particular hazard. According to EM-DAT, for the period 1998–2009, earthquakes in Europe rank second in terms of fatalities and third in terms of overall losses. Further, flooding, along with storms, is the most important natural hazard in Europe in terms of economic losses. Actions and measures, can reduce the economic impact of a hazardous event. Within this context, scholars, government agencies, professional organizations as well as local communities seek to understand the three main stages of a disaster (i.e. Normal/Risk Reduction Stage, Emergency Response Stage, Recovery Stage) and take measures to lower the negative impact. The goal of ISTOS is, by the end of the project, to significantly strengthen the Scientific Excellence and Innovation Capacity of the collaborative Advanced Infrastructures and Materials (AIM) laboratory established at the Frederick Research Center (FRC) and the Large Structures laboratory (LSL) established at the Cyprus University of Technology (CUT). The aim is to turn the collaborative laboratories at FRC and CUT into a Center of Excellence, “ISTOS”, which will be based in Cyprus. The proposed ISTOS project will achieve its goal by creating strong links between the AIM, LSL and two internationally leading research institutions namely the Aristotle University of Thessaloniki (AUTH) of Greece and the PLINIVS Study Centre, University of Naples Federico II (PLINIVS-LUPT) of Italy. Through ISTOS, the research profile and expertise of the staff, of FRC and CUT, will be raised while at the same time enhancing the S&T capacity of the linked institutions.

Keywords: natural hazards,vulnerability assessment,post disaster management
SAIL&CLEAN – A complete solution for sea cleaning: marine litter removal and optimal algal bloom harvesting (SAILCLEAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Europe is currently facing a huge and complex challenge when it comes to cleaning its oceans. On one hand, marine litter represents a tremendous environmental problem. Plastics pose a serious threat to all marine animals, as well as to boats and coasts. There are more than 150 million tonnes of plastics accumulated in the world's oceans while up to 8 million tons are added every year. On the other, eutrophication is causing an intensification of harmful algal bloom episodes, which lead to fish die-offs, cities cutting off water to residents, or states having to close fisheries. In the EU the annual cost of those blooms surpasses the €900 million. Municipalities and public authorities in charge of the preservation of the coasts still fail at targeting these issues at the same time because current solutions consist of either simple barges that collect debris in shallow waters or boats that can harvest the undesirable algae but unable to remove litter. Asco Harvester is an Icelandic SME committed to the development of a new family of efficient and sustainable boats that can tackle these two problems thanks to their dual functionality. Our boats can mow toxic algae and clean garbage and other waste from seas and ocean waters simultaneously. ASCO boats exhibit a very high harvesting productivity (40% higher than current harvesters) and are capable of working in difficult areas, such as fjords, open oceans or river canal. In addition, they incorporate a very efficient module able to capture up to 15 tons/day of plastic and other marine litter. We have implemented a business model based in selling and renting our boats to respond to seasonal demands thus maximising our business opportunity. By the end of 2024 (five years after market launch), we expect to have 70 units in the market: 38 units sold and 32 rented, with an associated cumulative profit of €11.2 M.

Keywords: harmful algal blooms,marine litter removal,innovate harvester boat
Colour-code labelling for continuous monitoring of quality and safety of packed chicken meat (FreshInk)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year, approximately 30 million tonnes of food is wasted in Europe because it was not consumed before the expiry date. Currently, expiry date labels do not provide an accurate indication of the food’s freshness, instead reflecting the worst case scenario of how long a product should be safe to eat. FRESHINK is an ink product that changes colour as the food’s freshness status changes, allowing consumers to make decisions on whether to eat or dispose of the product, based on the real freshness status of the food. CHIMIGRAF are an SME dedicated to the production, distribution and sale of liquid flexographic inks for the printing industry and the developers and owners of FRESHINK. They have developed and validated FRESHINK in the Spanish national project SENSOPACK. They now propose to use a phase 1 SME Instrument to confirm the market potential of FRESHINK labels, specifically targeting the market segment of packaged chicken breasts. The project will seek to i) validate the ink formulation and printing conditions at industrial scale, ii) test the label in real life conditions of packaged chicken breast meat, iii) engage consumers and stakeholders to validate market acceptance, iv) develop a comprehensive investor ready business plan. The outcome of the project will be a series of identified technical and market related challenges, and a strategy to overcome them, that must be completed by CHIMIGRAF in order to successfully launch the FRESHINK labels in the packaged chicken breast market. It is anticipated that achieving a market penetration of 5%, five years after the project has finished will earn CHIMIGRAF a profit of approximately 6.5 million Euros, and will help reduce European food waste by 25,000 tonnes annually.

Keywords: waste reduction,food safety,eco efficiency,food expiry,advanced label printing,food packaging,sustainable food production,shelf life,business model,modified atmosphere packaging
Dissecting the role of the epigenetic regulator TET2 in colorectal cancer (TETCOLON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) results from the accumulation of genetic and epigenetic changes in colonic epithelial cells. Epigenome studies revealed that virtually all CRCs contain aberrantly methylated genes and perturbed methylation patterns. Ten-Eleven Translocation (TET) protein family dioxygenases oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further to other oxidized 5mCs, supporting active DNA demethylation and helping maintain epigenomic stability. Loss of TET1 is an oncogenic driver in some CRCs. My preliminary analysis indicates that human CRCs have low TET2 mRNA levels compared to normal colorectal tissue, and suggests that low TET2 expression predicts increased mutational load and reduced overall survival. However, whether TET2 deficiency contributes to CRC pathogenesis, or represents a bystander event, remains to be established. In this proposal, I will elucidate the role of TET2 in CRC pathogenesis by testing whether TET2 knockdown induces methylome and transcriptome reprogramming, ultimately promoting (epi)genomic instability and tumor growth. I will also investigate correlations between TET2 defects and molecular/clinico-pathological parameters, and probe TET2 expression as predictive biomarker of response to CRC therapies. With these aims, I will use a multi-disciplinary approach, combining cell biology, cancer epigenetics, bioinformatics, human and mouse studies with cutting-edge techniques such as 3D cell culture and RNA-seq. This study should establish a clear causal link between TET2 loss and CRC pathogenesis, providing new insight into the mechanism of TET2-mediated tumor suppression and leading to the development of innovative therapies that exploit vulnerabilities of TET2-deficient CRC cells. Overall, this project has both basic and translational significance, and the potential to advance our understanding of CRC carcinogenesis and therapeutic response.

Keywords: colorectal cancer,active dna demethylation,tet2,cellular models,xenografts
Dynamics of Amorphous Semiconductors: Intrinsic Nature and Application in Neuromorphic Hardware (NEURAMORPH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2022-09-30
Duration (months): 84.0
Total project cost (EUR): 1499468.0
EU funding (EUR): 1297052.7
Participants: 2
Project status: CLOSED

After decades of perfecting the established way of computing, it is now evident that the fundamental logic of today’s computers will prevent them from ever reaching the efficiency of neural networks as found in nature. Neuromorphic hardware promises a leap forward by following the inherent working principles of biological neural networks. In very-large-scale integrated neuromorphic circuits incorporating an immense number of artificial neurons, the even much larger number of synapses poses the challenge of imitating especially the synaptic functionality in a most compact way. Over the last years, various memristive devices have been proposed to represent the weight of a synapse, determining how well electrical spikes are transmitted from one neuron to another. Existing attempts to achieve spike-timing-dependent plasticity, however, possess inherent problems. The NEURAMORPH project aims to develop a simple and compact circuit element to regulate the access to the memristive device for weight modifications. The dynamics of electrical excitability intrinsic to the employed amorphous semiconductors will naturally be able to mimic spike-timing-dependent plasticity. For full control over the properties of these synaptic access elements, a fundamental understanding of the relaxation processes in such amorphous materials is imperative. To this end, amorphization conditions will be systematically varied over a wide-range to create very distinct amorphous states. As a measure for relaxation the temporal evolution of their electrical properties will then be investigated. Based on experimental results for a variety of materials, molecular dynamics simulations will be employed to elucidate the relationship between elemental composition, structural dynamics and changing electrical excitability. Finally, as proof of concept, a prototype of a neuromorphic chip will be developed incorporating the new kind of synaptic device.

Keywords: neuromorphic hardware
Ship Lifecycle Software Solutions (SHIPLYS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Greece,Bulgaria,Croatia,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: System modelling and life-cycle cost optimisation for waterborne assets (H2020-MG-2015_TwoStages, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 6144150.0
EU funding (EUR): 6144150.0
Participants: 14
Project status: CLOSED

SHIPLYS has been specified as necessary by our architect, shipbuilder and shipowner members, who, in order to survive in the world market, need to improve their capability to reduce the cycle time and costs of design and production, to be able to reliably produce better ship concepts through virtual prototyping and to meet the increasing requirements for LCCA (Life Cycle Cost Analysis), environmental assessments, risk assessments and end-of-life considerations as differentiators. Yet, the calculation and modeling to do this is difficult and time consuming, especially for SMEs without a large overhead of trained staff and tools, due to difficulties in integrating data between incompatible tools and formats for different design stages: conceptual hull design; the finite element calculations feeding preliminary and detailed designs; and virtual prototyping simulation models. This is coupled with the lack of an industry specific lifecycle modeling technique, hindered by the lack of information to support reliable decision-making. SHIPLYS aims to transfer experience from the development of industry modeling coherence schemes e.g. BIM (Building Information Modelling), and use them to produce new techniques for quick, reliable multi-disciplinary modeling capability for the marine industry: - Develop standardization aspects of the new paradigm by transferring the key BIM Product Model principles: identify and capture the useful implicit information in existing CAD/CAE data and develop data formats to provide persistence for data reuse between design stages - Develop a Virtual Prototyping system to incorporate LCCA, environmental and risk assessment criteria, for fast and cost effective evaluation of alternatives - Add multi-criterion decision analysis techniques to support decision making across the short/ long term, based on explicit formulation matrix of ‘Buyer Utility;’ the key purchasing decision criteria - To build on ISO10303 standards for interoperable data reuse

Keywords: life cycle assessments and optimisation of ships,advance computing tools,virtual prototyping,simulation modeling cost analysis,multi criteria decision support,improving sme stakeholder viability
Urban vibrations: How physical waves come to matter in contemporary urbanism (WAVEMATTERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1997687.0
EU funding (EUR): 1997687.0
Participants: 1
Project status: SIGNED

Cities are critical zones where the intermingling of environmental processes, infrastructural arrangements and human lives is increasingly apparent and disputed. Physical waves, particularly heat radiation, sound waves and radio frequencies, constitute major environmental disturbances that invisibly cross the urban built environment affecting bodies, human and nonhuman, in harmful and uncertain ways. By asking how they come to matter, this project explores how waves become associated to specific bodies and environments, as well as how they become matters of public concern and design intervention. To answer these questions, this project entails extended ethnographic fieldwork at key locations where ur-ban projects aimed at mitigating the urban heat island effect, abating environmental noise and building 5th generation wireless communication networks are currently unfolding. Following techno-scientific researchers, city officials, professional consultants, affected groups and concerned residents, the project will address two major research problems: 1. How bodily exposure is done in practice, paying attention to both knowledge production and controversies concerning wave-related exposure, as well as to how individuals learn to be affected by and bodily attune to physical waves. 2. How waves problematize forms of urban coexistence leading to design interventions that reassemble (and disassemble) urban environments, as well as to practices of imagining other possible urban environments. A unique feature of this project is its emphasis on expanding conventional ethnographic research by means of multimodal collaborations with actors from the field, thus actively engaging in multimedia forms of knowledge pro-duction, prototyping or community building. This is indeed crucial to reassessing the material politics of the Anthropocene as entailing contested practices of materializing abstract or imperceptible environmen-tal disturbances.

Keywords: social studies of environmental hazard,affected communities,anthropology of infrastructures,knowledge controversies,ethnographic collaboration
Hybrid Networks for Global Internet Access (Forsway Next Gen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Forsway produces a unique solution to bridge the global digital divide now. Currently more than 45% of the world’s population, some 3.4B people, does not have access to affordable internet connectivity, a major obstacle to sustainable, equitable development. Providing economically viable broadband in the ‘problem terrain’ outside urban and suburban population concentrations is challenging. Forsway, a leading developer of hybrid satellite/terrestrial communications in Europe, has developed a unique hybrid communications solution which combines existing satellite and terrestrial mobile services to provide affordable digital broadband access. Our visionary team has a global perspective: to combine the best of satellite and terrestrial communications into hybrid networks, to connect the world to the internet. Our solution can bridge the digital divide now, rather than when delayed new infrastructure projects are ready. This approach is made possible by a very strong market position and close customer cooperation. This project is the first step in an accelerated commercialisation of our hybrid communications solution, bringing them to a successful market entry within 3 years. We anticipate, by 2023, connecting an additional 1M users to the internet, create huge economic and societal value in the underserviced markets of emerging economies in the developing world, as well as rural and remote regions in the developed world. This will generate €42M in revenue and 19 jobs for Forsway, and more than 150 jobs in our supply chain, as we address a €100B underserviced market.
Driving innovation in pharmaceuticals: integrated studies of physical dissolution properties of crystalline and amorphous forms using enhanced orthogonal monitoring techniques (CRYDIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 216000.0
EU funding (EUR): 216000.0
Participants: 6
Project status: CLOSED

The CRYDIS exchange programme will establish and support international and inter-sectoral transfer of knowledge and expertise in pharmaceutical and instrument science between several EU research institutes and industrial companies. It will also enhance understanding of the value of inter-sectoral exchange mechanisms for taking research to market. CRYDIS undertakes innovative, collaborative research on the clinically-important topic of dissolution of drug substance particles in bio-relevant media and the undesired subsequent nucleation and re-precipitation of the drug prior to its absorption. Using innovative advances in UV imaging technology, CRYDIS investigates the utility of novel dissolution assays as key tools to obtain fundamental data on the mechanism and kinetics of undesired nucleation and re-precipitation during or following dissolution, a significant problem for the pharmaceutical industry which struggles to obtain sufficient exposure to poorly soluble drug substances to ensure an effective dose is absorbed by the patient. The key technologies in this proposal offer a step change in capability and functionality, offering the potential to undertake more detailed studies of the dissolution/re-precipitation processes relevant to pharmaceutical materials. Access to this key technology and the further development of its capability offers the potential for breakthroughs in development of process understanding and of robust and widely applicable protocols. Additional value is brought to CRYDIS through close working with synergistic European networks, leveraging a greater knowledge input and impact outreach. Running parallel with the science programme, an innovation management work-package analyses effectiveness of the exchange mechanism in building a shared culture, transferring knowledge and developing understanding of processes that drive a product to market. The outcomes of this will be used to advise and drive potential future exchange activities.

Keywords: combined techniques for enhanced characterization of physical processes key target materials of pharmaceutical relevance developing enhanced methods to improve industrial processes