Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploiting genome replication to design improved plant growth strategies (PLANTGROWTH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-06-01
End date: 2025-05-31
Duration (months): 72.0
Total project cost (EUR): 2497800.0
EU funding (EUR): 2497800.0
Participants: 1
Project status: SIGNED

This project will identify the principles governing genome replication in relation to the chromatin landscape and how they impact on plant organ growth. The results will provide the basis to design novel strategies to improve plant growth performance. The large plant genomes, as in all eukaryotes, must be faithfully duplicated every cell cycle, a process regulated at the level of DNA replication origins (ORIs). Our understanding of how ORIs are determined is still very limited. Most of our knowledge comes from cultured cells, precluding the identification of regulatory layers operating at the organism level. Importantly, genome replication can offer unexplored possibilities to modulate plant architecture and growth and, consequently, plant performance. Results generated so far unable us to address a fundamental question: what are the regulatory mechanisms of DNA and genome replication and how they can be exploited to design improved plant growth strategies. This innovative perspective will reveal how genome replication is regulated by DNA sequence context, replication factors and chromatin landscape. Integration of molecular, cellular, genomic and genetic approaches in a whole organism will serve to evaluate the phenotypic effects of modulating genome replication on organ growth. We will also learn how DNA replication control is exerted during endoreplication and in coordination with transcriptional programs, both crucial for plant organogenesis, growth and response to environmental stresses. This program goes beyond incremental research, is timely, innovative, ambitious but realistic, and high risk/high gain, combining different approaches to address a fundamental process. Given the conservation of proteins and pathways, and the availability of well-annotated genomic information for many plant species, PLANTGROWTH will pave the way to translate the technological and conceptual know-how derived from this program to crop species to improve yield.

Keywords: plant,organ growth,dna replication,endoreplication,dna replication proteins,cell cycle,chromatin,epigenetics,histone marks
Effective Factorisation techniques for matrix-functions: Developing theory, numerical methods and impactful applications (EffectFact)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ukraine,Germany,Italy,Italy,Italy,Israel,Italy,Norway,China,Russian Federation,Belarus,Poland,Switzerland,Slovakia,Slovenia,Georgia,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2026-02-28
Duration (months): 54.0
Total project cost (EUR): 1858400.0
EU funding (EUR): 1821600.0
Participants: 30
Project status: SIGNED

The main goals of the EffectFact proposal are a) to advance pure and applied mathematics in the area of factorisation techniques, Wiener-Hopf and Riemann-Hilbert problems and related numerical techniques to solve time dependent boundary value problems in complex discrete and continuous domains; b) to utilize the developed techniques to solve challenging problems from: i) biomechanics (DNA replication), ii) medicine (surgical resection and dentistry), iii) metamaterials (acoustic and gyro-elastic), iv) AI (machine learning), v) environmental and civil engineering (with a focus on earthquake and coastal defences) and, in doing so, c) to establish a new, sustainable, EU-centred network of researchers from different sectors and disciplines, united by their dedication to furthering the projects techniques and results, while transferring this knowledge, best practice and creating new training opportunities for EU researchers. The EffectFact consists of 24 Partners: 9 Academic Institutions from the EU (UK, France, Germany, Italy, Poland), 6 Universities from the AC (Georgia, Israel, Norway and Ukraine); 8 highly innovative SMEs adopting completely different R&D strategies (UK, Switzerland, France, Slovenia, Israel, Slovakia); 1 Academic Partners from the TCs (China). All EffectFact goals align with the RISE Objectives, establishing a unique consortium to fill gaps in several scientific disciplines, impacting H2020 priorities and Horizon Europe missions. These problems could not be solved independently, requiring continuous feedback from analytic, applied and computational researchers from numerous disciplines. This diverse collaborative Network will forge interdisciplinary links within the EU, strengthen the access of EU academics and SME’s to international research, lead to tangible and impactful results, while building a strong base of robust, independent researchers capable of furthering the aims of EffectFact long into the future.

Keywords: wiener hopf and riemann hilbert techniques,factorisation techniques for matrix functions,system of singular integral equations,biomechanics,medicine,geomechanics,environmental engineering
Antimicrobial wound care solution to prevent and cure wound infections and cut health care costs (SGSOFT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Finland
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With new bacteria constantly becoming resistant to antibiotics, wound infections are ever more dangerous and cause vast economic costs to society at large. Antimicrobial wound dressings, which by definition contain silver, are the most efficient method to prevent and cure wound infections. Until today, however, such have been too expensive and known to release too much silver to the wound and blood circulation. Based on R&D and clinical trials at HUS (Helsinki University Hospital) since 2009, Silvergreen has successfully developed an affordable antimicrobial wound dressing that prevents and cures infections, and dramatically reduces the use of antibiotics and costs. Technically, SGSOFT neutralizes all known bacteria by a safe application of ionic silver (Ag+). SGSOFT is patented, Medical CE approved and ready for wider hospital verifications and mass-market uptake. The solution has disruption potential, but requires a shift in wound care practice from merely treating infections with antimicrobial dressings to preventing infections with (affordable and safe) such dressings. Even if SGSOFT is technically ready to be sold in the EU and countries that accept Medical CE, practical trials are required in the leading hospitals of the target markets to successfully introduce the new medical device to end-users – and to ultimately make SGSOFT an active part of every citizen’s and home’s medical first aid repertoire. Silvergreen lacks resources to fully respond to the vast demand. Based on initial market studies, the go-to-market strategy builds on Finland, Denmark, the Netherlands and UK as the entry markets and diabetics as the entry segment. SGSOFT is available in different forms to B2B and B2C customers with varying cost structures and price points. Based on an initial analysis, each 1€ of consumer purchases of SGSOFT reduces public wound care costs with 5€. Silvergreen envisions to reach global sales of 100M€ by 2020 which translates to total cost savings of 500M€.

Keywords: cost effective antimicrobial silver wound dressing infection prevention infection cure bacteria
WADI (WADI)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Italy,Italy,Italy,Belgium,Poland,France,France,France,Portugal,Portugal
Call: Demonstration/pilot activities (H2020-WATER-2015-two-stage, 2015)
Start date: 2016-10-01
End date: 2020-07-31
Duration (months): 46.0
Total project cost (EUR): 4724143.99
EU funding (EUR): 3826955.75
Participants: 15
Project status: CLOSED

The overall objective of WADI project is to contribute to the reduction of losses in water transmission systems and decrease the related energy consumption required for the process. WADI aims to develop an airborne water leak detection surveillance service to provide water utilities with adequate information on leaks in water infrastructure outside urban areas, thus enabling the utility to promptly repair them. The project idea relies on innovative concept of coupling optical remote sensing and their application on two complementary aerial platforms, i.e. manned and unmanned, typically used for distinctive purposes in infrastructure performance observation. The former is being used in long-distance monitoring whereas the latter in ‘particular’ areas observation, i.e. those with a limited/difficult physical access or requiring closer monitoring upon earlier detection of some anomalies in aircraft missions. Following the determination of cameras’ optimized wavelengths (suitable particularly for water leaks detection), the WADI technology will be applied in an operational environment represented by two pilot sites, i.e. in France (Provence region, case of water supply mains) and Portugal (Alqueva, case of multi-purpose mains serving irrigation, water supply, and hydro power). The WADI proposal addresses the challenge of building a water (and energy) efficient and climate change resilient society by integrating the concept of ecosystem services through the recovery of up to 50% of the water lost at a cost which is lower by an order of magnitude than the cost of terrestrial techniques – e.g. 50-200 EUR/km for airborne technology vs. 1,000-5,000 EUR/km for ground techniques. The project includes legal aspects assessment (related to data protection and regulatory standards for use of UAV), market analysis and strategy along with the corresponding business plan and a dissemination plan that addresses key stakeholders.

Keywords: water transmission,leak detection,multi spectral and ir imaging,remote sensing,airborne,optical sensors,surveillance,service,innovative optical sensors,market up take,ecosystem
Exploring the molecular control of seed yield in crops (ExpoSEED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Australia,Germany,Spain,Argentina,Italy,Colombia,United States,Netherlands,Japan,Mexico
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 522000.0
EU funding (EUR): 486000.0
Participants: 11
Project status: CLOSED

ExpoSEED aims to integrate forward and reverse genetic approaches to dissect the molecular mechanisms that control seed/kernel (hereafter referred as seed) yield in model species and to transfer the acquired knowledge to selected crops as legumes and cereals. The identification of “molecular hubs” that determine seed number and size will put the basis for the development of breeding tools to improve seed production at the beginning of the seed market. Research on model species has recently allowed to identify key transcription factors that regulate plant reproduction together with exploring the conservation of the molecular mechanisms that finally control the plant fitness in distantly related species. The next challenge is now to deeper dissect the molecular networks controlled by these key factors to finally manipulate agronomic traits. The partners of ExpoSEED will identify the targets of key transcription factors in model species as Arabidopsis and rice and they will transfer this knowledge to crops, as soybean, wheat and barley. Candidate target genes will be further characterized using genetic and cell-biology tools together with searching new alleles in large panel of wild and cultivated germplasm. As a parallel approach, germplasm collections and segregating populations will be used for mapping studies to identify novel factors controlling seed yield in legumes and cereals. ExpoSEED aims to create synergies to efficiently address scientific and societal issues. From the scientific perspective, now is the right moment: a number of completed crop genome sequences and novel genetic and cell biology tools will support the comparative biology approaches aimed in this project. Considering the societal issue, food security is a worldwide priority: in the context of population growth and less arable land, increasing food production is one of the challenges for this century

Keywords: crop improvement,seed yield
Innovative Distributed Electrical Network (IDEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain,Italy,United Kingdom
Call: Innovative Primary and Secondary Electrical Distribution Network for Regional A/C (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2021-11-30
Duration (months): 38.0
Total project cost (EUR): 1399037.5
EU funding (EUR): 1399037.5
Participants: 4
Project status: CLOSED

With the introduction of the more electric aircraft greater emphasis is placed on the power generation and distribution architecture as a result of increased power demands and higher efficiency needs, as well as the interest in using electrical power for more flight critical applications. Together with the steady drive for reduced weight, increased reliability and reduced maintenance, this leads to the requirement for new approaches for the aircraft electrical supply generation and distribution, managed intelligently to maximise efficiency and ensure safe aircraft operation under all conditions. The prime aim of the project is the design, development and test of an ‘Innovative Primary & Secondary Electrical Distribution Network for Regional A/C’ based upon state of the art power semiconductors and enhanced electrical energy management (E2-EM). The EPGDS to be designed comprising 2 Primary Power Centres - PPC, 4 Secondary Distribution Units - SDU, 2 AC/DC converters, solid-state based contactor/breakers - SSPC and externally provided System Supervisor & DC/DC converter interface between HV & LV primary bus bars. The system will be designed to interface to the REG Iron Bird facilities. The design of each LRU will be based upon the use of state of the art power semiconductor devices, innovative circuit topologies and embedded intelligence. A foundation stone of the EPGDS system is the effective modelling of each of the LRU’s and the overall system to enable the investigation of diverse operating conditions, permit verification of correct functionality and highlight any deficiencies at an early stage. In addition it will permit the use of automatic code generation of each LRU embedded controller. All designs will take into account the specification requirements for avionic equipment in order to facilitate future development to production & certification. Thermal, vibration and EMC survey of key elements will be performed.

Keywords: epgds,epds,solid state breaker,wbg devices,smart grid,automatic code generation,enhanced electrical energy management,hardware in the loop,model in the loop
Functional characterization of specialized metabolites from gut microbiomes (SMs-Gut)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Composition changes of the human gut microbiome has been associated with a series of diseases. However, little is known about the mechanism of this microbiome alteration. Recent in silico studies revealed thousands of biosynthetic gene clusters (BGCs) that encode diverse types of specialized metabolites from human microbiomes. Many of these molecules are potentially involved in shaping microbiome structure or directly affect host cell and contribute to disease development. To date, only colibactin, a hybrid polyketide/non-ribosomal peptide produced by Escherichia coli in human gut, has been experimentally validated for its deleterious metabolic impact on human host and linked to the development of colorectal cancer (CRC). Thus, this project aims to expand the knowledge of specialized metabolites produced by gut microbiome and unravel their role in development of inflammatory bowel disease (IBD) and CRC. State-of-the-art bioinformatic, synthetic biology and chemical-analytic technologies will be used to tackle this challenge. In silico identification of BGCs will be facilitated by sequence homology search and the occurrence of function-related resistant makers. The cloning process will be realized by either capturing native BGCs, adopting polymerase amplification or using synthetic DNA, followed by HiFi DNA assembly, Red/ET recombineering based DNA integration method or combining of both strategies. The chemical diversity of these specialized metabolites will be unlocked by heterologous expression of the cloned BGCs and structure elucidation of the produced molecules. The biological functions of the discovered compounds will be established by probing their genotoxicity and cytotoxicity in vitro with human intestinal cell lines.

Keywords: gut microbiome,biosynthetic gene clusters,specialized metabolites,synthetic biology,intestinal diseases
Deciphering tumor-promoting mechanisms mediated by neutrophils in vivo (CINPinCB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

Immunotherapies are revolutionizing cancer care, but are only effective in a minority of patients. Because current treatments typically target T lymphocytes, manipulating other cell types will create additional therapeutic opportunities. This research project aims to study neutrophils, because they can be abundant in the tumor environment, can modulate tumor outgrowth and response to treatments, and are candidate new therapeutic targets. However, tumor-associated neutrophils can be phenotypically and functionally heterogeneous, with only some of them promoting tumor growth. At present, we have a limited understanding of the complexity of neutrophils in tumors, and the mechanisms that control the functions of these cells. This is largely due to the inherent experimental limitations of neutrophil studies. Here, we will use a new approach to test the hypotheses that so-called Conditionally-Immortalized Neutrophil Progenitors (CINP) can be: 1) used to produce unrestricted numbers of tumor-associated neutrophils in vivo, and 2) gene-edited to study neutrophils mechanistically during cancer progression. Addressing these questions bears scientific and therapeutic importance, as it will not only deepen our fundamental understanding of the mechanisms regulating neutrophil activities in cancer, but also indicate new molecular targets for therapy. With this study, I will also create and share a publicly available database of all newly identified targets that will be investigated by us, other academic research groups, and industry. Besides, the project’s outputs will be communicated to the broader general public. Altogether, the training and input I will receive during the Marie Curie Individual Fellowship will prepare my transition from post-doc to independent researcher in an excellent scientific environment in Europe.

Keywords: cancer,neutrophils,immunotherapy,cancer immunity,conditionally immortalized progenitors,crispr,cas9 gene editing,genetic screen,protumoral mechanisms,predictive biomarkers,therapeutic targets
5G: A LeadershIp Vision for Europe (5-Alive)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Italy,Germany,Germany,Norway,France,France,France,United Kingdom
Call: Smart optical and wireless network technologies (H2020-ICT-2014-1, 2014)
Start date: 2014-11-01
End date: 2015-10-31
Duration (months): 12.0
Total project cost (EUR): 550241.25
EU funding (EUR): 348643.0
Participants: 11
Project status: CLOSED

The approach of the 5-Alive project will be to use an innovative mix of community and industrial support to produce the essential material and to perform an intensive communications programme. The project proposes to establish effective processes to capture, synopsise and present frequent news updates on the activities of the European 5G initiative and ensure their widespread dissemination. The project involves a number of key industrial players, who are active in lead roles in both the ETP and the Association, and are contributing manpower to the project activities at their own cost, to ensure the investment is shared between industry and the EC. Thus the funding model of this proposal is a true reflection of the stakeholder interests in and commitments to the European 5G-Infrastructure-PPP. The main 5-Alive project objectives are: • Produce an updated roadmap for the holistic network perspective (including 5G) via the NetWorld2020 ETP, • Actively promote and position the European 5G Initiatives as part of the leading global initiatives, • Stimulate the involvement of the European ICT community and consumer sectors as drivers of evolution, • Facilitate the 5G-Infrastructure-Association production of strategies for later phases of the 5G-PPP, • Conduct a first exercise on mapping the 5G-PPP KPIs to the research challenges to determine which topics will directly contribute to obtaining the foreseen infrastructure performance/feature improvements. The project will run for one year to boost the 5G activities in the short-term in advance of the kick-off of 5G project related activities and to position the 5G PPP initiative as “the” European initiative in the 5G domain at global level.

Keywords: 5g ppp,infrastructure