Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrodynamics of Double Membrane Spreading in Biology (HYDROBIOMEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: CLOSED

Eukaryotic cells exist in highly dynamic environments and are subject to a variety of existential threats, ranging from viruses to pathological defects in their own genome. To cope with these challenges, cells have developed a conserved pathway in order to degrade harmful objects internal to the cell. This process is know as autophagy. Autophagy involves the formation of a double lipid membrane compartment that wraps around harmful targets, such as damaged organelles, protein aggregates or lipid droplets in order to facilitate their degradation. Although the genetic and molecular triggers for autophagy have been analysed in much detail, the biophysical principles governing such a dynamic process have received remarkably little attention. The biophysics of autophagy is highly complex biophysical process, involving the driven, non-equilibrium morphodynamics of a fluid membrane that must wrap its target. This incorporates molecular signalling and adhesion, vesicular trafficking and active force generation and complex flows of the lipid membrane in curved geometries as well as the Stokesian hydrodynamics of the embedding fluid. This makes the dynamics of autophagy essentially a problem of active soft matter physics. In HYDROBIOMEM I will build on demonstrable expertise in active soft matter physics, morphology and fluid dynamics to develop novel theoretical and computational models to give mechanistic understanding and predictions of the dynamics of double membrane wrapping in autophagy. I will apply these tools, in close collaboration with experimentalists, to test existing biological hypotheses and give new insight into this ubiquitous process in cell biology.

Keywords: membrane hydrodynamics biological soft matter wetting low reynolds number hydrodynamics
The GMOS: a Novel Sensing System to reduce food loss during transportation. (GMOS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Food waste, especially in fruits and vegetables, is a pressing global issue, with a staggering 644 million tons discarded annually, constituting 42% of total production. Inefficient monitoring and management across the supply chain contribute significantly, with substantial waste occurring during distribution and post-harvest stages due to inadequate detection methods. TODOS has developed the GMOS sensor, an innovative IoT-based solution designed for continuous monitoring of ethylene—the crucial hormone governing fruit ripeness. Unlike traditional approaches, GMOS employs a nanoparticle-catalyzed thermal sensor array that offers unparalleled sensitivity (10 ppb to 100 ppm) & selectivity in ethylene detection. Enhanced with edge AI algorithms, the sensor provides real-time insights into ripening dynamics, enabling precise identification of overripe produce & optimization of supply chain logistics. The GMOS sensor, with its unique ethylene detection capabilities, plays an important role in the de-greening rooms, during the supply chain. Its cost-effective operation % adaptability to diverse environmental conditions ensure scalability across cold supply chains, with minimal power consumption for long-term sustainability. The tiny-edge ML/AI analytics platform delivers actionable data to stakeholders, improves direct cloud-based connectivity, reduces latency and expenses, facilitates informed decision-making to minimize waste, and improves operational efficiency. Under the EIC accelerator, TODOS focuses on refining sensor technology through catalyst optimization and rigorous validation with industry partners. Pilot projects with leading fruit exporters and storage facilities validate GMOS's efficacy in reducing spoilage and operational costs. Industrialization efforts aim to establish robust supply chain partnerships and enable widespread adoption, positioning GMOS as a transformative solution in global efforts to combat food waste and promote sustainable agriculture.

Keywords: food packaging food contamination food technology secure food chain and wealth products food wastage
Space-based space surveillance enabling automated satellite operations (Vyoma)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

As the number of satellites and debris launched into orbit increases at an accelerating rate, satellite operations are becoming more complex, and safety issues are exceeding acceptable limits. At the same time satellite missions themselves are becoming more demanding and complex, too, imposing more and more constraints when it comes to efficiently navigating this dangerous environment. Vyoma tackles this challenge by observing debris objects from space (initially three, later up to 12 passive-optical observation satellites) and by bringing automation to the forefront, with a drastic reduction in costs. Backed by state-of-the-art processing algorithms, end-to-end automation of operations is pursued, with collision avoidance between space assets and debris at its core. With that, Vyoma will become the trusted one-stop shop in satellite operations.

Keywords: space situational awareness space traffic management space safety satellite operations space debris automated decision making
Novel lightweight smart Wearable Cardio Defibrillator for Sudden Cardiac Arrest detection (DBelt)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Sudden cardiac arrest (SCA) is a lethal problem of the heart’s electrical system usually called ventricular tachycardia (VT) or ventricular fibrillation (VF), which causes the heart to fibrillate and in most cases causes sudden cardiac death. SCA causes ~20% of all deaths in Europe, is lethal within minutes if left untreated and survival rates across Europe are presently only 10% on average. However, the current standards of care face low compliance rates with existing wearable cardiac defibrillator (WCD) solutions, false positives leading to unnecessary shocks, and a lack of real-time monitoring of heart data. Addressing these problems, NewPace introduces DBelt™, an innovative wearable cardioverter defibrillator. This lightweight device, features a non-invasive, flexible belt design worn around the waist, complemented by disposable patches affixed to the patient's skin. These patches incorporate defibrillation pads, ECG sensors, and vibration module, facilitating continuous monitoring and timely intervention during sudden cardiac arrest events. It accurately and autonomously detects and analyses arrythmias due to its revolutionary algorithms and in case of VF or VT, delivers a high voltage and high energy electrical shock to the heart to reset the rhythm back to normal. Furthermore, its novel online monitoring system, powered by a sophisticated detection algorithm validated through extensive clinical trials, enhances patient adherence and streamlines healthcare delivery. With its non-intrusive design, wireless recharge capabilities, and remote monitoring features via Low Energy Bluetooth (BLE), DBelt™ offers unparalleled convenience, accessibility, and value to both patients and healthcare providers. Through the EIC project, the company aims to optimize its arrythmia detection algorithms and complete clinical validation, secure regulatory approvals before market entry.

Keywords: algorithms,remote digital,telemedicine wearable medical device,defibrillator
Multi4 - the first surgical instrument for bladder cancer treatment through a 20-minute outpatient procedure (Multi4)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 3561428.57
EU funding (EUR): 2493000.0
Participants: 1
Project status: SIGNED

Bladder Cancer (BC) is the most overlooked cancer type in terms of the development of new surgical tools aimed at achieving efficient cancer treatment. The instruments used in the operating room have remained unchanged since the 1960s. The standard of care involves a rigid metal cystoscope and a surgery under anaesthesia. The inherent risks to the patient are manifold, encompassing damage to the urethra, frictions, infections, and the potential reseeding of cancer cells elsewhere in the bladder. The lack of progress in this field is evident in the statistics: this cancer type has the highest recurrence rate of all cancers - up to 75%. In BC, approx. 60 % of healthcare costs are attributed to patient surveillance and treatment of recurrences. BC remains one of the most expensive cancers to manage and treat globally. Multi4, established by the experienced surgeon and women innovator Miden Melle-Hannah, is developing a ground-breaking surgical instrument that allows for effective treatment of BC in outpatient settings. This innovation transforms the patient's healthcare journey. Instead of the waiting period for difficult and hazardous surgeries, patients can now have their tumours removed directly in the urologist's office. This advancement is made possible through cutting-edge deep tech innovations in instrument engineering design. These innovations result in a surgical tool which integrates four functionalities (thus we call it “Multi4”): 1. Inject local anaesthesia through a thin needle; 2. Remove cancerous tissue using specially coated forceps; 3. Transport the cancer tissue out through the instrument itself; 4. Burn the area where the cancer was located to ensure the elimination of all cancer cells. This project will close the gap to market for Milti4 through clinical studies, transfer to production and certification according to MDR. The technology we propose is the first attempt since the 1960s to develop a new type of instrumentation for the treatment of BC.

Keywords: urology and nephrology,bladder cancer,surgical instruments,endoscopic procedures,outpatient care
Reliable, Efficient and Fast Industrial Internet: A High-Resilience, Low-Latency API acceleration for global and interplanetary industrial services (XRTC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 3232185.83
EU funding (EUR): 2262530.08
Participants: 1
Project status: SIGNED

Existing major industries run on UDP protocols and have high latency and low resilience in their communication networks, affecting their output and causing millions of euros in losses or unrealized revenue. Examples of the highest impacted fields include the mining, energy, maritime, and space sectors. TCP-based protocols can overcome these challenges but are limited by transmission delays Delta Cygni Labs has developed XRTC, an elastic and resilient TCP based protocol for API acceleration, together with the European Space Agency (ESA), to serve delay and disruption-prone business cases. We offer faster communication, better connectivity, and enhanced control over internal communication addressing day-to-day challenges across mining, energy, maritime, and space sectors and allowing them to draw business value from space-grade communication capabilities. With the help of the EIC accelerator, we will launch the European deep-tech XRTC to the key verticals, perform market validation, and expand into the global market.

Keywords: internet services and applications,networks communication networks,sensor networks,networks of robots,etc,fifth generation cellular network technology 5g,durable and elastic networking
Relativistic Spin Hydrodynamics: Theory and Applications (RelSpinHydro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 210789.12
EU funding (EUR): 210789.12
Participants: 1
Project status: CLOSED

This proposal establishes connections between fluid dynamics, quantum field theory, and mathematical physics to develop new tools to better characterise out-of-equilibrium properties of relativistic quantum many-body systems. My work is instrumental to understand the emergence of novel fluid-like behaviours which are not apparent in the fundamental laws. The focus of my research is the quark-gluon plasma (QGP), an exotic phase of quantum chromodynamics (QCD) where quarks and gluons are not confined inside of nucleons. The QGP is formed in relativistic heavy-ion collisions performed at the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider (RHIC). A huge surprise was the discovery that the QGP behaves as a relativistic liquid with very special properties, namely, it flows with the lowest specific viscosity of any known liquid, and it is by far the system with the largest vorticity ever observed. Such large vorticity triggers particle polarisation, which is a phenomenon resembling the magnetisation displayed by a ferromagnet that is spinning around an axis. This effect shows the interplay between a macroscopic quantity, the fluid rotation, and a microscopic quantity, which is inherently of quantum nature: the spin of the particles. The recent observation of polarisation phenomena of hadrons emitted from the rotating QGP in heavy-ion collisions calls for a new formulation of relativistic fluids where spin degrees of freedom are crucial to the dynamics -- this is called relativistic spin hydrodynamics. Despite fluid dynamics being an old subject, the formulation of the full causal and stable theory of relativistic spin hydrodynamics which can be used for theoretical predictions is yet to be developed. Expected outcomes from this proposal include: * the formulation of causal and stable theories of relativistic spin hydrodynamics, * their extensions to the far-from-equilibrium regime, * applications to QGP physics.

Keywords: relativistic hydrodynamics,heavy ion collisions,quark gluon plasma
Fungal pathogenicity emerging through functional adaptations to host environments (FungalPath)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1478047.0
EU funding (EUR): 1478047.0
Participants: 1
Project status: SIGNED

Fungal infections pose a serious medical threat, especially when they invade the bloodstream. The most common cause of fungal bloodstream infections is invasive candidemia, primarily attributed to a small group of pathogens, including Candida albicans, Nakaseomyces glabratus, Candida tropicalis, and Candida parapsilosis. Such infections are associated with crude mortality rates nearing 40%. Increasing numbers of very closely related yet non-pathogenic species have been sequenced and identified. However, a functional understanding of what differentiates them from their pathogenic counterparts is lacking. As fungal pathogenicity is a multifactorial trait that is influenced by intrinsic and extrinsic factors, it is hard to explain directly from genomic data. This proposal aims to address these challenges by integrating molecular data with physiological contexts across a broad set of species with varying pathogenicity. By leveraging recent advances in mass spectrometry-based analytics that allow for large-scale molecular profiling of both microbial pathogens and human biofluids, combined with high-throughput methods for deep phenotyping of microbial isolates, and by using and identifying scalable yet physiologically relevant growth conditions and infection-relevant phenotypes, we aim to (1) identify adaptations required for pathogenicity and their molecular basis; (2) identify infection-relevant phenotypes and metabolic differences that distinguish pathogenic from non-pathogenic species; and (3) obtain a quantitative understanding of host-pathogen physiology and their interactions. Thus, we aim to uncover traits, phenotypes, and conditions that enable and intersect with pathogenicity. These breakthroughs will be critical for managing and combating these life-threatening infections and predicting the future emergence of human fungal pathogens.

Keywords: mass spectrometry,host pathogen interactions,systems biology,metabolism,fungal infections and pathogenicity
Overcoming the sign problem in lattice gauge theories using tensor networks (OverSign)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1795300.0
EU funding (EUR): 1795300.0
Participants: 2
Project status: SIGNED

Tensor networks, and particularly projected entangled pair states (PEPS), are special quantum many-body states that describe strongly-correlated systems well due to their entanglement structure. They have been successfully applied in various scenarios and recently to lattice gauge theories (LGTs) where they outperformed conventional Monte-Carlo calculations and overcame the sign problem in some examples, but mostly in single-space dimensions due to limitations of tensor network methods. A fundamental analogy between PEPS and gauge theories suggests that PEPS are suitable for studying LGTs and that gauge symmetry, often seen as complicating the numerics, can help in overcoming the sign problem and perform efficient tensor network computations in higher dimensions. The overarching goal of this project is to use this analogy in analytical and numerical ways, aiming to (1) analytically devise a comprehensive new formalism for LGT PEPS and the physics they describe by allowing one to construct the optimal PEPS to be used as variational ansatz states when combined with numerical techniques; (2) devise numerical methods for studying LGTs with such PEPS thanks to the analogy, based on sign problem-free variational Monte-Carlo; (3) apply these methods numerically to challenging, non-perturbative models, culminating in SU(3) in 3+1-D, with finite fermionic density, towards quantum chromodynamics. This is expected to overcome the sign problem of such models, thus closing an important, challenging and long-standing gap in the field of non-perturbative physics in general, and gauge theories in particular. The developed methods can be generalized for studying real-time dynamics of quantum field theories, models of quantum gravity, thermal quantum field theories and many other puzzling questions. They will also advance the parallel contemporary approach to LGT - quantum simulations and computations - as some open problems are shared by both approaches.

Keywords: tensor networks,lattice gauge theory,entanglement,variational monte carlo,sign problem,qcd,fermions
WoodNDame - Reconstructing the climate and medieval woodland management strategies from the charred woods of Notre-Dame de Paris: contribution of dendrochronology, wood anatomy and carbon isotope data (WoodNDame)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2025-11-01
Duration (months): 25.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The unfortunate event of April 15th 2019, the Notre-Dame de Paris’s cathedral (NDP) fire, brought a unique and extraordinary opportunity to study past environmental conditions prevailing in the Paris Basin through charred oak wood pieces. Partly dated between the 11th and 13th centuries, the charred woods from the roof structure of the NDP open a unique window into the Medieval Climate Anomaly (≈ 950–1250 CE), a period characterised by warm and dry summers that profoundly influenced society during the High Middle Ages (HMA), especially in Europe. Furthermore, the major pieces of the roof framework correspond to trees of ca 20-25 m in height with small diameters (30-50 cm), which suggest specific woodland management. By investigating uncharred and charred tree growth rings from NDP, the WoodNDame project will aim to provide an annual and seasonal high temporal resolution reconstruction of the interaction(s) between climate–forest–woodland management systems during the HMA. To reach this goal, the project will first develop a pioneering and interdisciplinary methodology - combining dendro-anatomical features and state-of-the-art isotopic (δ13C) analysis – to provide (i) a comprehensive picture of the impact of carbonisation on oak wood anatomical and chemical properties at inter- and intra-ring scales and (ii) a modern reference using these multiproxy approach based on 15 wood stands in the Paris Basin for disentangling dendroclimatological and woodland management signals.

Keywords: notre dame de paris,charred wood,growth rings,climate,woodland management