Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Guiding Refugees via European Exchange and Training (GREET)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Germany,Finland,Belgium
Call: Science4Refugees - Support to highly skilled refugee scientists (H2020-SwafS-2017-1, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 201871.25
EU funding (EUR): 201871.25
Participants: 3
Project status: CLOSED

There is a consensus that universities have an important role to play in the reconstruction of conflict-torn societies, and that is where competent scholars are needed. However, very often, not enough attention is placed on the important role of universities and academia in emergencies. Integration of recently arrived refugee students and scholars into the European academic community serves thus long-term capacity-building in their home countries. Universities in different European countries have been active in initiating support measures for threatened students and scholars and in some countries, such as in Finland and Germany, national level actors have also been active in coordination of the support measures. However, a European-level forum for the higher education sector to focus on this specific field has been lacking. The GREET project addresses this need by providing a platform for actors on institutional, national and international level to join their expertise. GREET's main goal is to strengthen European cooperation and information sharing on existing and good practices in the integration of highly skilled refugees in the higher education system and labour market in host countries. It aims to achieve this goal through providing networking, training and mutual learning opportunities for refugee support structures at national and institutional level in 9 European countries. Taking as its basis the existing good practices from Germany and Finland, the project will scale them up to the European level through peer learning activities and a series of webinars, which will serve for dissemination, exchange and mapping different support needs in Europe. The project results will be disseminated to the wider European higher education community through a big stakeholder forum and an online repository, targeting both practitioners and policymakers at European and national level.

Keywords: peer learning,european cooperation,refugee students and scholars,cross country support,higher education institutions
Exploring Relations in Structured Data with Functional Maps (EXPROTEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1499845.0
EU funding (EUR): 1499845.0
Participants: 1
Project status: SIGNED

We propose to lay the theoretical foundations and design efficient computational methods for analyzing, quantifying and exploring relations and variability in structured data sets, such as collections of geometric shapes, point clouds, and large networks or graphs, among others. Unlike existing methods that are tied and often limited to the underlying data representation, our goal is to design a unified framework in which variability can be processed in a way that is largely agnostic to the underlying data type. In particular, we propose to depart from the standard representations of objects as collections of primitives, such as points or triangles, and instead to treat them as functional spaces that can be easily manipulated and analyzed. Since real-valued functions can be defined on a wide variety of data representations and as they enjoy a rich algebraic structure, such an approach can provide a completely novel unified framework for representing and processing different types of data. Key to our study will be the exploration of relations and variability between objects, which can be expressed as operators acting on functions and thus treated and analyzed as objects in their own right using the vast number of tools from functional analysis in theory and numerical linear algebra in practice. Such a unified computational framework of variability will enable entirely novel applications including accurate shape matching, efficiently tracking and highlighting most relevant changes in evolving systems, such as dynamic graphs, and analysis of shape collections. Thus, it will permit not only to compare or cluster objects, but also to reveal where and how they are different and what makes instances unique, which can be especially useful in medical imaging applications. Ultimately, we expect our study to create to a new rigorous, unified paradigm for computational variability, providing a common language and sets of tools applicable across diverse underlying domains.
MONKS, NUNS AND TEXTILES: Production, Circulation, and Distribution of Textiles in the Monastic Environment in Egypt (4th-8th Centuries AD) (MONTEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2020-10-02
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The MONTEX project will consider Egyptian society in the Late Roman, Byzantine and Early Arab periods through its economy and material culture. It focuses on the production, circulation, and distribution of textiles. Textile production was one of the most important branches of the Egyptian economy at the time. This research will be conducted using the example of the monastic environment. As monks and nuns came from all social groups, their professional occupations and everyday life strongly correspond in many aspects with the lifestyle of lay people. The sources related to monastic environment are numerous and provide us with some information unavailable elsewhere regarding lay craftsmen and customers. This comparative research will be conducted in interdisciplinary studies combining all kinds of sources: archaeological evidence, iconographic representations, and literary, normative, and documentary texts written in a bilingual Greek and Coptic environment. The MONTEX project provides studies on the provision of raw materials, and the organisation of textile production and craft training, also considering the gender aspect of these topics. The studies of the circulation and distribution of textiles will focus on the innovative topic of textiles not destined for clothing and used in various contexts. It also offers new lexicographical approach to the Greek vocabulary concerning textiles and their production. The main goal of this research is a synthetic study of textiles in Late Roman and Byzantine Egypt, a topic which has never received interdisciplinary and comparative analysis. The Project will be hosted by the University of Copenhagen’s Centre for Textile Research (Denmark), a highly specialized centre for textile studies. The secondment institution will be the Université Paris Ouest – Nanterre La Défense (France), with its Department of Art History and Archaeology famous for teaching and research into Mediterranean material culture.

Keywords: late roman and byzantine egypt,economy,material culture,textiles,monasticism,archaeology,papyrology,greek lexicography
Promoting EU-funded projects of inclusive, innovative and reflective societies (DANDELION)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Italy,Slovakia,Greece,United Kingdom,Portugal
Call: Communication and dissemination platform (H2020-REFLECTIVE-SOCIETY-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 979438.5
EU funding (EUR): 979438.0
Participants: 7
Project status: CLOSED

Dandelion will promote the work done by inclusive, innovative and reflective societies’ projects on a local, regional and European level by developing and implementing a series of innovative and exciting communications activities aiming to inform, educate and entertain a wide cross section of the European population, policy makers, academics and media. By placing European economic and financial reform, the problems young people face in Europe, cultural heritage, European values and diversities, the EU's role as a global actor and the new forms of public sector innovation at the heart of these activities, by involving established science educators, by creating clear lines of communication between projects and named mass media and by utilising novel communications, Dandelion will ensure that inclusive, innovative and reflective societies’ ambitious philosophy is given the highest profile. By giving tools and guidelines to the dissemination managers towards general public, policy makers, academia and media Dandelion will guarantee an improved access to research projects’ data in the future.
Embodied Ecologies: An Ethnographic Study of Reproductive Toxicity, Infertility, Endometriosis and Delayed Childbearing (EndoReproTox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

This ethnographic project reframes the study of infertility by considering reproductive health as an environmental issue. It is specifically interested in the relationship between exposure to endocrine-disrupting chemicals (EDCs), infertility, and endometriosis, a common hormonal disorder that disrupts the female menstrual cycle and is strongly correlated with both infertility and EDCs. How are these links understood in expert and public contexts, and how do they factor into the way people make decisions about fertility and childbearing? By focusing on understandings of causality instead of treatments/technologies, and by conceptualizing health as an "embodied ecology" instead of a product of individual choices and behaviors, this project has implications for health policy and public awareness as well as anthropological theory. Working with Diana Marre at the AFIN Research Group at the Universitat Autònoma de Barcelona, the pre-eminent site for the interdisciplinary social study of reproduction, will provide me with the support and training to conduct this innovative research and reach professional maturity. Over twenty months of fieldwork consisting of interviews and participant observation in Barcelona, Europe's leading site for infertility treatments, with short fieldwork trips to California for an important comparative perspective, this project connects my prior experience researching reproductive decisions in California with demographic and health challenges affecting Europe and Western societies more broadly. Training will focus on proliferating my methodological skills and enhancing my ability to communicate across sectors and to the public, which will be enabled by AFIN's inter-sectoral connections with medical centers and its unique Center devoted to public outreach. Dissemination will consist primarily of three peer-reviewed articles, six conference presentations, two public talks, and two public newsletters.

Keywords: medicine,environment,toxicity,health,reproduction,endometriosis,chemicals
An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds (AgePhagy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 149872.0
EU funding (EUR): 149872.0
Participants: 1
Project status: CLOSED

The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project, we showed that genetic upregulation of autophagy, major cellular degradation pathway, increased lifespan, which we aim to mimic by pharmacological treatment. To this end, we developed the CellAge epigenetic clock, which is based on DNA methylation and which is the first clock that accurately detects subtle ageing changes in human primary cells in vitro upon a short anti-ageing drugs treatment, as shown using rapamycin and trametinib. This differentiates our clock from other available epigenetic clocks which are designed to accurately determine human age in years. By connecting the CellAge clock to autophagy drug library we will test the commercial viability of our anti-ageing drug assessment platform. To further validate our CellAge clock as a robust human ageing biomarker, we will combine its outputs with longevity assays in vivo in Drosophila. The final outcome will be an innovative and accelerated discovery platform for sought after anti-ageing/geroprotector drugs, which we will in this first instance test autophagy modifier drugs. Throughout the project we will closely collaborate with our industrial collaborator, GSK and UCL Business, which will assure we maximise the potential of our platform. Our ultimate goal is to uncover novel autophagy modifiers with anti-ageing properties and to launch the CellAge clock as the most advanced platform for expedited discovery of anti-ageing compounds.

Keywords: autophagy,ageing,epigenetic,epigenetic clock,pharmacology,anti ageing drug,lifespan,health span
Sleep microstructure in Parkinson's Disease and REM-sleep Behavior Disorder (Sleep_PD-RBD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Idiopathic REM sleep Behavior Disorder (iRBD), a condition characterized by abnormal behaviors during sleep associated with dream enactment, is considered a prodromal state of Parkinson’s disease (PD). Both disorders share a common pathophysiology consisting of abnormal protein deposition from the gastrointestinal tract to the brain via ascending pathways. Whereas motor aspects have been extensively studied in iRBD/PD, a comprehensive view of the effects of the pathology on sleep-wake microarchitecture is still lacking. This Sleep_PD-RBD project focuses on the sleep disturbances associated with iRBD/PD and what they may reveal about the neurodegenerative process. Besides characterizing alterations in vigilance state regulation and sleep oscillations, I will correlate these EEG observations to gastrointestinal symptoms and daytime sleepiness, which both greatly impair patients’ quality of life. The original aspect of this project consist of studying sleep alterations with the recent concept of sleep and wake as non-mutually exclusive states, emphasizing sleep-wake dynamics as opposed to sleep scoring with conventional polysomnography variables, and with innovative EEG analyses investigating the properties of specific sleep oscillations and their cross-coupling. The project also links the brain to the guts, a current hot research topic. This multi-disciplinary project will rely on retrospective databases of patients obtained in Lyon and collaborative centers across France, as well as ongoing recruitment of patients and controls. For this project, I will benefit from the strong expertise of the Lyon Neuroscience Research Center in neuroscience research and of the Center for Sleep Medicine and Respiratory Diseases of Lyon University Hospital for clinical research aspects. With this fellowship, I aim to reintegrate the French academic network in an ideal research setting to learn technical and team-leadership skills and grow into a qualified independent researcher.

Keywords: synucleopathies,rapid eye movement sleep,non rapid eye movement sleep,neural oscillations,microbiome,vigilance,sleepiness
Stochastic Transport in Upper Ocean Dynamics (STUOD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,France,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-03-01
End date: 2026-02-28
Duration (months): 72.0
Total project cost (EUR): 9998875.0
EU funding (EUR): 9998875.0
Participants: 3
Project status: SIGNED

71% of Earth is covered by ocean. The ocean has absorbed 93% of the heat trapped by human’s greenhouse gas emissions. The ocean’s future responses to continued warming are uncertain. Our project will deliver new capabilities for assessing variability and uncertainty in upper ocean dynamics. It will provide decision makers a means of quantifying the effects of local patterns of sea level rise, heat uptake, carbon storage and change of oxygen content and pH in the ocean. Its multimodal monitoring will enhance the scientific understanding of marine debris transport, tracking of oil spills and accumulation of plastic in the sea. Our approach accounts for transport on scales that are currently unresolvable in computer simulations, yet are observable by satellites, drifters and floats. Four scientific capabilities will be engaged: (i) observations at high resolution of upper ocean properties such as temperature, salinity, topography, wind, waves and velocity; (ii) large scale numerical simulations; (iii) data-based stochastic equations for upper ocean dynamics that quantify simulation error; and (iv) stochastic data assimilation to reduce uncertainty. These four scientific capabilities will tackle a network of joint tasks achieved through cooperation of three world-calibre institutions: IFREMER (ocean observations, reanalysis); INRIA (computational science); and Imperial College (mathematics, data assimilation). Our complementary skill sets comprise a single systemic effort: (1) Coordinate and interpret high-resolution satellite and in situ upper ocean observations (2) Extract correlations from data needed for the mathematical model (3) Perform an ensemble of computer simulations using our new stochastic partial differential equations (SPDE) which are derived by matching the observed statistical properties (4) Apply advanced data assimilation and computer simulations to reduce model uncertainty The key to achieving these goals will be synergy in our combined expertise.

Keywords: observation technology,device implementation,data analysis,theoretical modeling with stochastic mathematics,computational simulation and data assimilation for fluid dynamics
Clinical research for the validation of a non-invasive medical imaging device for dermatological diagnoses (DERMAE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Diagnosis and study of many diseases in dermatology, including cancers, mainly depend on biopsy and histopathological analysis of tissue at the cellular-level using an optical microscope. This medical procedure implies to perform a biopsy, i.e. to excise a portion of tissue, then to freeze and cut the sample into slices of a few micrometers thickness and use specific dyes. This procedure is painful and potentially dangerous for the patient. Moreover it is time-consuming and may introduce structural deformation or damages. Skin diseases like Melanoma are rapidly growing throughout the world. About 12 millions biopsies are performed each year by dermatologists. As a minor surgical act, the biopsy process involves pain, possible scarring, and stress during the 15 days before reception of analyses results. In 60% of the cases, the skin anomaly is benign and do not necessitate further treatment. However, the patients need to consult another time with the dermatologist for the announcement of the results of the biopsy, which incurs extra medical costs and time. Moreover, as symptoms are detected on a macroscopic-level with surface criteria (color, form and size of the lesion), the dermatologist misses over one third of the pathologies. Finally, as the tissue excision is visually performed, 40% of reoperation is necessary to remove the entire tumor. DERMAE is a highly recognized and awarded innovative project that solves this major healthcare issue by developing an innovative instrument capable of producing in situ images of biological tissues similar to histological sections. This non- invasive imaging technique will be able to image in real time the internal structures (up to 1 mm deep) of biological tissues at the cellular level (about 1 μm resolution). This imaging technology will constitute a new diagnostic tool that may revolutionize the medical procedures in dermatological diagnoses.

Keywords: non invasive optical imaging process,dermatological diagnoses,melanoma