Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of Notch signaling pathway in Glioma Stem Cells (NOTCH PATHWAY IN GSC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-06-01
End date: 2014-09-20
Duration (months): 24.0
Total project cost (EUR): 233705.2
EU funding (EUR): 233705.2
Participants: 1
Project status: CLOSED

Glioblastoma multiforme (GBM) is the most common malignant intracranial tumor in adults. Despite the knowledge of the genetic alterations associated to GBM and the improvement in neurosurgery and chemo- and radiotherapy, little improvement has been achieved in the median survival. Recently, glioma stem cells (GSCs) have been identified to be responsible of the origin, recurrence and drug resistance in GBM, constituing so an attractive therapeutic target in the fight against gliomas. The present project aims to study the biology of GSCs and characterize their genomic and transcriptomic in response to inhibitors of the Notch pathway. This pathway has been demonstrated to be very important in glioma and alterations in components of this pathway have been identified in GBM. The research line proposed here will be multidisciplinary and in close contact with the patient. The objectives of the present project are: 1. Isolation of GSC from clinical samples obtained after brain surgery through sorting for stem cell markers and characterization by SNP arrays, RT-PCR, CGH, etc. 2. Analysis of the response to Notch inhibitors in GSCs ex vivo and in vivo. Analysis of the status of this pathway in GSC and the response to Notch inhibitors in culture (proliferation, apoptosis, neurosphere formation, differentiation, etc) and in vivo after injection of GSCs intracranially into mice. Gene expression analysis of tumors treated with Notch inhibitors in order to identify genes associated with response to treatment. 3. Test of candidate genes involved in resistance to treatment in vitro and in vivo. By blockade using RNA interference or inhibitors. 4. Clinical correlation. Results obtained in the laboratory will be correlated with clinical data from patients involved in the Notch inhibitor clinical trial in our Hospital. Since this GSCs share characteristics with other cancer stem cells, such as colon and breast, the results of this study can be extrapolated to other tumor types.

Keywords: anticancer therapy,glioblastoma,cancer stem cell,notch,cd44
Lexical Meaning and Logical Inference (LEXMEAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 226548.4
EU funding (EUR): 226548.4
Participants: 1
Project status: CLOSED

The project aims at systematically examining the relationship between three debates in three different disciplines: the problem of logical constants in philosophy of logic, the debate on the functional vs. lexical distinction in linguistics, and the debate on the semantics vs. pragmatics distinction in philosophy of language. Our hypothesis is that these seldom-connected debates actually address the same set of underlying issues. In particular, we will argue that to give an account of semantic content, and to provide a principled answer to the question of where to draw the line between semantics and pragmatics, is correlated, on the one hand, with identifying criteria that distinguish the logically valid inferences from other inference patterns, and, on the other, with an account of the lexical and functional properties of the expressions of a given language. We will further examine whether the distinction between logical vs. non-logical expressions maps onto the distinction between functional vs. lexical (or 'substantive') categories. If our hypotheses are correct, then not only will the language of logic and natural language turn out to be intimately connected, but we will also gain new insight into the distinction between function words and content words. While our main goal is to address conceptual issues, we will flesh out and test our hypotheses through three case studies, involving respectively indexical pronouns, prepositions, and degree modifiers. The latter two will allow us to enrich our dominantly theoretical approach with standard methods from corpus linguistics, as well as statistical methods, such as distribution modelling.

Keywords: semantic content,logical constants,functional vs. lexical dichotomy,indexicals,semantics-pragmatics interface,degree-modifiers,prepositions,meaning,context
Electron Correlation - The Electronic Ground State of Graphene Nanoribbons (ELECTRON CORRELATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 168896.4
EU funding (EUR): 168896.4
Participants: 1
Project status: CLOSED

Graphene nanoribbons are derivates of graphene. Since its discovery in 2004 by Andre K. Geim and Konstantin S. Novoselov it has received enormous attention earning its discoverers the 2010 nobel prize. The great interest in graphene originates in its unique properties. Graphene nanoribbons are an interesting building block for spintronics. In standard electronics the information carrier is the charge (the electron). When a charge current is present the signal is “on”, when there is no charge current the signal is “off”. In this setup the spin information (“up” or “down”) is completely ignored. Graphene nanoribbons, however, offer the possibility to add the spin degree of freedom to conventional electronic devices. The advantages are numerous. It has been shown theoretically that electrons localise on the sides of nanoribbons. This electronic structure is reminiscent of the electronic structure of the H2 molecule at dissociation limit. The dissociated H2 molecule is the prototype system of static correlation. In this project recently developed theories and methods that accurately describe static correlation are applied to graphene nanoribbons. To investigate the electronic ground state structure with an efficient implementation of the theories and methods will be developed. In this project Prof. Angel Rubio, scientist in charge and head of the nano bio Spectroscopy group at the at the Basque Country University (UPV/EHU) in San Sebastian, Spain, Prof. Gustavo Scuseria, head of the quantum chemistry group at Rice University in Houston, USA, and Dr. Daniel Rohr, researcher in the project, join forces to investigate the electronic structure of graphene nanoribbons. The project will be executed by Dr. Daniel Rohr. He will join the group in Spain for 24 months during which he will spend approximately 6 months in Houston.

Keywords: quantum chemistry,electron correlation,graphen nanoribbons
Specificity of Antibiotic Resistance Evolution (SPECRESEVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Bacterial resistance to antibiotics is a major problem for global public health, but we have an incomplete understanding of the evolutionary and genetic factors that drive the spread of resistance. This proposal is motivated by the concept that some of the key processes in resistance evolution depend on the specificity of the genetic mechanisms involved, which is at present unclear. Specificity here refers to variation of the phenotypic effects of mutations across genotypes (epistasis) or environments. I will use a combination of microbial experimental evolution, DNA sequencing and evolutionary genetics to address this problem. My objectives are to: (1) quantify the specificity of antibiotic resistance mutations across different concentrations of a range of antibiotics; (2) identify genetic mechanisms that ameliorate growth defects caused by resistance mutations (compensatory adaptation) in different resistant genotypes in both the presence and absence of antibiotics; (3) test whether compensatory adaptation to the cost of one resistance mutation can also recover the cost of other resistance mutations against the same or other antibiotics. This work will improve our understanding of the genetic and evolutionary factors that drive antibiotic resistance evolution.

Keywords: evolutionary biology,genetics,microbiology,antibiotic resistance,experimental evolution
Dissemination of proneural brain cancer cells: implication of partial and reversible differentiation into Dcx+ cells. (DCXGLIOMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

Gliomas describe a range of devastating and progressive brain tumours affecting around 25000 people each year in Europe. Glioblastomas represent the most severe and frequent form of gliomas. A major finding in the field of glioblastomas is the recent identification of cancer stem cells within the tumour, holding a high tumorigenic potential. Those stem cell-like cancer cells are multipotent and resistant to radio- and chemotherapy, and are thus very likely to be responsible for the tumour recurrence after surgical resection. They possess as well high migratory properties, strongly understudied so far. Their anarchic dispersion through the parenchyma of patients represents the main hurdle to surgical resection therapy, and their ability to re-generate a tumour threatens the therapeutic outcome. That is why a deep understanding of the mechanisms preferentially borrowed by glioma stem cells to spread and survive should lead to adapted therapeutic strategies. This project is based on the original discovery by JP Hugnot’s group that glioma cells can spontaneously express the neuroblast marker Dcx to enter a migratory program in vitro, and in vivo. Interestingly, Dcx+ and Dcx- glioma cells from the same culture share different migratory and tumorigenic properties. This project aims at deciphering the respective intrinsic properties of Dcx+ and Dcx- gliomas cells in terms of migration and tumorigenicity, and to identify which molecular pathways influence these properties (with a focus on Notch and Shh based on preliminary data). For that, several resources are already available and in Pr Hugnot’s group: cell sorting, gliomas cell lines reportering the expression of Dcx (Gli4 pDcx-GFP), migration assays, cell transplantation of Dcx+ or Dcx- cells in the brain of nude mice. When further developed, these results will provide a substantial advance in the field of brain cancer research, and will open up significant therapeutic perspectives for the treatment of gliomas.

Keywords: gliomas,dcx,invasion,cancer stem cells.
Methane GeoMicrobiology in the Iberian Pyritic Belt Subsurface (MET-IPBS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-16
End date: 2015-01-04
Duration (months): 24.0
Total project cost (EUR): 176053.2
EU funding (EUR): 176053.2
Participants: 1
Project status: CLOSED

The subsurface of both marine and terrestrial environments has been rising a lot of interest lately, more since it was shown that its biogeochemical cycles are more active than originally thought. The Iberian Pyritic Belt (IPB), one of the largest sulfide deposits on Earth, is situated the southwestern Spain. It is the source of the highly acidic Tinto River, maintains a low pH (mean 2.3) and a high metal concentration, especially Fe(III), along almost its whole length. The high acidity predates the extensive mining of this area, being caused by the activity of the chemolithotrophic microbial community found in the subsurface, whose main source of energy is the oxidation of the pyrite with release of Fe(III) and sulfate. The geomicrobiology of the IBP subsurface is poorly studied. A recent drilling project has shown the existence of methane deep in the subsurface, and, together with the geochemical data, it points toward microbial methanogenesis. This proposal aims toward a multidisciplinary and interdisciplinary approach to study the geomicrobiology of methane production/consumption in the IPB subsurface. A broad suite of tools from geology, microbiology, geochemistry, mineralogy and molecular ecology will be used to achieve the following: (i) to determine where in the subsurface are methanogenesis and methanotrophy taking place; (ii) to determine the methane sources and sinks; (iii) to identify and characterize the microorganisms involved into the methane cycling, their energy sources and electron acceptors, and the metabolic pathways employed; (iv) to characterize the microbe-mineral interactions associated with the methane cycling, and (v) to develop a geomicrobiological model for the methane generation and consumption and its relevance for the C cycle in subsurface. This proposal is in line with the international trend in research toward the understanding of the subsurface environments, and it will contribute to the excellence of the European Research Area.

Keywords: geomicrobiology,methanogenesis,methanotrophy,iberian pyritic belt subsurface,microbe-mineral interactions
cerebellar molecular layer Interneuron network imaging in awake animal (INTERNEURON NETWORK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 201932.4
EU funding (EUR): 201932.4
Participants: 1
Project status: CLOSED

Molecular layer interneurons form an interconnected network in the cerebellar cortex that controls the activity of Purkinje cells. Even though much is known about the properties of these interneurons in isolated preparations, their activity pattern in vivo remains largely unknown. The present project proposes to investigate the functional status of the interneurons in awake, head-restrained mice, by performing two photon calcium imaging of the cerebellum with genetically-encoded calcium indicator GCaMP3. Imaging speed will be improved by implementing random access multi point scanning with acousto-optic deflectors. Once the basic activity pattern will be known, effect of sensory stimulation (tactile stimulation or eye puff) and rhythmic behavior (licking behavior) will be explored. In a second step of the project, calcium imaging of the interneurons will be combined with whole-cell recordings of postsynaptic Purkinje cells. In this manner the effects of interneuron network activity on the overall cerebellar circuit will be assessed. The results will be evaluated with the help of a collaborating modeling team. This study will shed light on the functional role of molecular layer interneurons, and more generally, on the way by which interneurons regulate the activity of brain network. It will also provide data that will help evaluating consequences of defects of gabaergic transmission in cerebellar pathologies. The applicant will benefit from the multidisciplinary training provided by this project.

Keywords: neurophysiology,cerebellum,interneuron network,3d calcium imaging,patch clamp,in vivo,spatiotemporal dynamics
Beyond the Frontiers of Latin Christendom: The Avignon Papacy and the East (AVORI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2015-01-31
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

This research conjugates the history of the Avignon Church and the history of East West relations in the Late Middle Ages, shedding new light on the intellectual debates that developed within the Avignon Curia concerning Greeks, Armenians, Mongols, and Muslims. Despite an increasing scholarly interest in these research areas, studies on the Avignon Papacy have been characterized by an overwhelmingly local approach, whereas the relations of the medieval Papacy with different Eastern populations have not been sufficiently integrated within a comprehensive investigation on the Orient. This research aims to fill the gaps in the scholarly literature by examining how intellectual debates that developed within the Avignon Curia contributed to the shaping of Western ideas about the East. Based on the scrutiny of diplomatic sources, theological treatises, and travel reports, the study will shed light on the Western perception of the East in the Late Middle Ages from the perspective of intellectual history. Relying on comparative and interdisciplinary research methods, it will produce a comprehensive overview of the cultural reception of the Orient by the Avignon Curia, centered on the shaping of ideas about four major populations. The results will advance our understanding of the intellectual and political history of the Avignon Papacy through placing it for the first time in a wider, transnational context. The focus on the fourteenth century raises issues of continuities and discontinuities between medieval and modern European expansion. By applying the analytical category of Frontier to the Avignon context it will be possible to establish direct links with later European expansion into the New World and measure the success and endurance of medieval theoretical models developed by Roman Catholic Church. Thus, the proposed research will make key contributions to intellectual history, cultural history, history of inter-confessional relations, Church history and religion.

Keywords: medieval history,church history,non-christian religions
An Evaluation of the Legacies of Sporting Mega Events on Social Capital in Greece (LEGACIESOCIALCAPGR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 215701.2
EU funding (EUR): 215701.2
Participants: 1
Project status: CLOSED

This study aims to examine the social legacies of the Olympic Games and other sporting mega events in Greece and more specifically focuses on the impacts and legacies that such events can have on social capital as an important aspect in maintaining a productive and lively society. Roche (1994, p. 1) describes mega events as “short-term events with long-term consequences”. This description points clearly to the economic as well as political, social and cultural motives that persuade cities and countries to bid for the hosting of events such as the Olympic Games. One of the problems of evaluating legacy impacts across a range of dimensions (e.g. social, cultural, health, environmental and economic) is that there is an inevitable pressure to convert these dimensions into a single economic and ‘tangible’ measure to facilitate the evaluation of performance. However, defining ‘legacy’ is problematic especially if conceived as an entirely predictable or measurable set of objectives. Studies on the social impacts and mega events are very limited, while research evidence on mega events and the social impacts in relation to certain activities (such as volunteering) or marginal social groups (such as immigrants) has been even rarer. Especially the impact of sporting mega events in enhancing social capital (e.g. through the development of a sense of place and community pride) is largely unresearched. This project aims to address this absence in the relevant literature and to provide further knowledge through rigorous theory-informed research and scholarship. There are two major research questions: 1) What are the impacts of sporting mega events on social capital? (Positive or negative)/ do they generate short-term or long-term legacies? 2) How sporting mega events affect the social capital of specific groups? a) How volunteering affects individuals? b) To what extent sporting mega events have an impact on the social capital of marginal populations such as immigrants?

Keywords: social sciences
Adespota Papyracea Hexametrica Graeca (APHG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-19
End date: 2015-09-18
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

The project consists of an edition of the unidentified hexametrical texts on papyri and parchments from Oxyrhynchus, Egypt. The corpus will include 77 papyri, 49 of which are preserved at the Oxyrhynchus Collection in Oxford. New readings will be provided through a direct inspection of the original papyri housed in the Sackler and the Bodleian Libraries in Oxford, in the Egyptian Museum in Cairo, as well as 13 other European and American institutions. A revision of the texts will suggest different interpretations of the fragmentary compositions. The candidate will also search for unpublished hexametric material within the Oxyrhynchus Collection in Oxford under the guidance of his mentor, Dr. Dirk Obbink. A complete transcription of only partially transcribed papyri will be provided; 51 of the 77 items, still lacking translation, will be translated and analyzed; 12 previously unavailable photographical reproductions will be included; bibliological and paleographical information on single items will be provided. The draft intended for publication will include: an introductory chapter on the hexametrical compositions copied in the city of Oxyrhynchus during the Roman and Late Antique times; commented editions of the texts; analytical indexes (index of Greek words, indexes of historical and mythological names) and concordances with previous corpora.

Keywords: humanities classics papyrology hexameters