Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Full sky neutrino astronomy with the Deep Core of IceCube (NEUTRINOSICDC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 172686.39
EU funding (EUR): 172686.39
Participants: 1
Project status: CLOSED

The main objective of the IceCube neutrino telescope is to open a new observational window in astrophysics by detecting high-energy neutrinos of cosmic origin. Such observations will shed light on acceleration mechanisms of highly energetic cosmic rays and allow a mapping of their sources. The IceCube detector is still under construction, but in its current configuration, it already produces data of unprecedented quality. IceCube’s site is optimal to observe neutrinos coming from the Northern sky. We propose here to make the first attempt to observe the Southern sky as well in a single analysis, with the use of the “Deep Core” of IceCube, so to develop the first full sky neutrino telescope. Deep Core is a nested dense array at the center of IceCube that will be deployed during the next two austral summers. We will use the strings of IceCube surrounding Deep Core as a veto volume in order to reject the huge background from cosmic ray air showers that would completely mask the astrophysical neutrino signal. In addition to this veto capability, the denser instrumentation of Deep Core will result in a lower energy threshold than for IceCube (below the TeV), which is crucial for the study of many potential neutrino sources, in particular galactic objects. New reconstruction techniques will have to be developped and the performances of this unique detector established with simulations and with the first IceCube Deep Core data. The experience of the candidate in astroparticle physics, especially two years of post-doctoral research in the IceCube collaboration, will allow her to become quickly a leading element on these techniques, especially for the optimization of track vertex reconstruction and of the veto algorithms. The early involvment of the host group at MPI-K Heidelberg in the design of Deep Core and in the combined analysis of the data from IceCube and its predecessor, AMANDA, provide a perfect scientific framework for the development of this project.

Keywords: physical sciences - neutrino - astroparticle - high energy astrophysics - cosmic rays - galactic sources - icecube
Laboratory earthquakes: dynamic shear cracks in heterogeneous frictional interfaces (EARTHCRACKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 212729.11
EU funding (EUR): 212729.11
Participants: 1
Project status: CLOSED

The main objective of the proposal is to expose an outstanding young experimental physicist to multidisciplinary research on earthquake dynamics. Dr. Julien Scheibert who is already an expert in friction and fracture dynamics will perform original research and receive training at the Norwegian Centre of Excellence, “Physics of Geological Processes” (PGP) at the University of Oslo. By working with geologists and physicists with a proven record of cross disciplinary research Dr. Scheibert will broaden his competences and reach a deeper level of insight into fracture and friction in Nature. The main methods to be applied are novel model experiments in which a highly controlled disorder is introduced at a frictional elastomer-on-glass multicontact interface mimicking a seismic fault and correlated to the dynamics of both the nucleation and propagation phases of a shear crack. The dynamics of the slip field over the whole interface will be monitored optically using high speed camera acquisition and digital image correlation techniques. The acoustic signals emitted during rupture will be registered simultaneously by broadband transducers. The experimental data will be compared with earthquake field data, continuum and discrete modelling and theoretical approaches in collaborations with experts at PGP. This project should strengthen a multi-disciplinary approach to seismology in Europe, by gathering experts in geosciences, statistical physics and mechanical engineering and promote new collaborations between them.

Keywords: earthquakes,mechanical and thermal properties,experimental physics,statistical physics
Structural Analysis of Mathematical Proofs (STRUCTPROOFS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-11-01
End date: 2011-10-31
Duration (months): 24.0
Total project cost (EUR): 157279.59
EU funding (EUR): 157279.59
Participants: 1
Project status: CLOSED

Proof Theory is the branch of mathematical logic that investigates formal proof systems modelling mathematical reasoning. There are different types of proof systems, each having its own advantages and disadvantages. A certain class of proof systems (Gentzen-type systems) has the interesting property of exhibiting a geometric structure in proofs. Logical and proof-theoretic problems that are formulated in the context of these systems are thus susceptible to analysis by geometric and combinatorial methods. The recent years have seen a development of a great variety of such methods by different communities. The aim of the proposed project is the application of these geometric and combinatorial techniques to logical problems in proof theory. The proof-theoretic problems have been carefully selected in order to lend themselves well to the analysis by these methods. The scientific impact of this project will be twofold: On the one hand, the solutions of the problems will be of importance for proof theory and the foundations of mathematics in their own right. On the other hand, the combined application of combinatorial methods from different traditions will have a unifying effect on them, leading towards a general theory of proofs as combinatorial structures.

Keywords: mathematical logic,discrete mathematics,computer science
Single Particle Cryo-Electron Microscopy and Biophysical Characterization of Transient Receptor Potential Vanilloid 2 channel: a Three-Dimensional Structure Characterization of a Membrane Nociceptor. (PAIN_TRPV2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-08-01
End date: 2012-07-31
Duration (months): 36.0
Total project cost (EUR): 248814.33
EU funding (EUR): 248814.33
Participants: 1
Project status: CLOSED

The IOF call is a unique opportunity for the researcher to carry out this project. Transient Receptor Potential channels are extremely interesting since some of them are receptors for pain (nociceptors). The actual subject of research is the structural characterization of TRPV2, a nociceptor which responds to different stimuli such as cannabidiol, pressure and noxious heat. TRPV2 is expected to be a large membrane protein (potential homotetramer of ~400 KDa). To study TRPV2’s 3D structure, single particle Cryo-Electron Microscopy is the most suitable method. Further biophysical characterization of the inactive and active states of TRPV2 by FTIR spectroscopy and differential scanning calorimetry will be carried out. The research results will contribute to drug therapeutics on acute and chronic pain treatment. The Outgoing phase will take place at Brigham and Women’s Hospital (affiliated to Harvard Medical School, Boston U.S.A.). The present proposal gathers a skilful and experienced Outgoing host in single particle Cryo-Electron Microscopy (Supervised by Dr. Montserrat Samsó) with a talented and experienced young researcher (Dr. Alex Perálvarez-Marín) in order to generate a transfer of knowledge to a European host. This is the recently created Centre d’Estudis en Biofísica (Supervised by Prof. Esteve Padrós), in the Department of Biochemistry and Molecular Biology at the Universitat Autònoma de Barcelona (Spain), which is looking for a potential enhancement in its Structural Biology section. The Return host is embedded in Barcelona’s unique scientific environment. The ongoing Centre d’Estudis en Biofísica and the Mare Nostrum Supercomputing facilities, in addition to the new Alba Synchrotron and the planned Institute for Structural Biology, are a very suitable environment to reintegrate the researcher by means of this advanced and innovative research project, expected to strongly contribute to the European excellence and competitiveness.

Keywords: biochemistry,biophysics,cryo-electron microscopy,3-d structure,pain,transient receptor potential channels,ftir spectroscopy,dsc
SUSTAINABLE DESIGN OF MANUFACTURING SYSTEMS (SUSTAIN-MS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 171466.19
EU funding (EUR): 171466.19
Participants: 1
Project status: CLOSED

The contribution of SUSTAIN-MS to EU manufacturing added value refers to environmental sustainability issues addressed through more efficient model-based design of manufacturing systems that will yield more efficient production by reduced waste and energy use. The way to achieve this is to apply machining processes with advanced cooling-lubrication and to adapt machine tools to such a stage that the process vibrations are decreased. In support of SUSTAIN-MS design efforts the following sustainability measures will be defined: manufacturing process energy use, ancillary energy, machine tool vibrations, tool consumption and waste, cooling-lubricants, CO2 emissions, costs, health and safety. The major milestones of SUSTAIN-MS research relate to the optimised sustainable design of machining process and cooling-lubricants parameters, the solution of vibrations stability for particular machining process and the integration of machining process micro level models with the machine tool macro level models. The SUSTAIN-MS training activities that are not directly connected to scientific and technical research include the acquirement of complementary research skills, dissemination skills, project management skills and training in education. The SUSTAIN-MS objectives are in accordance with politically endorsed sustainable manufacturing directives underlined in the EU Sustainable Development Strategy and the EU Environmental Technology Action Plan.

Keywords: technological sciences,mechanical engineering,manufacturing systems,sustainability,modelling
FoldAmeRs : a new family of G-QUADruplex ligands (FAR-QUAD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 174535.75
EU funding (EUR): 174535.75
Participants: 1
Project status: CLOSED

This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy. The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines. However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase. Therefore, the use of small molecule ligands to induce quadruplex stabilisation in telomeric DNA has potential as an anti-cancer strategy. A European collaboration recently engaged between I. Huc (Bordeaux, France) and S. Balasubramanian (Cambridge, UK) groups already led to the identification of a very promising compound, with exceptionnal potential for stabilising human G-quadruplex telomer. In addition a three dimensionnal helical compound (foldamer) has shown interesting activity. This project, involving chemistry, biology and biophysic, aims i) to systematically design and develop new analogues of this promising candidate, based on aromatic delta-peptide chemistry; ii) to evaluate their G-quadruplex binding affinity in telomere and others systems; iii) to establish structure-activity relationships; iv) to determine the key elements necessary for specific G-quadruplex recognition by solving the structure of the first ligand complexed with G-quadruplex. This original interdisciplinary proposal involves two international leading groups in their respective field, to develop new tools and knowledge on the growing interest on natural G-quadruplexes as new target for anti-cancer strategy. The applicant will have a crucial role in the development of this collaboration and will become an active and efficient third partner, when returning back to China at the end of the fellowship.

Keywords: foldamer,g-quadruplex,cancer
A Micro Level Analysis of Communal Violence in India with a new Database on Maharashtra (RIOTS AND WELFARE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 158912.58
EU funding (EUR): 158912.58
Participants: 1
Project status: CLOSED

Civil conflicts have resulted in hundreds of millions of victims worldwide and constitute one of the most obvious impediment to economic development. Conflict studies have thus attracted a growing attention by economists since the 1990s. Essentially because of data limitations, empirical studies of conflict have mostly been led at the macro level. As such, it is quite unsatisfactory as there remains a gap between the theoretical frameworks highlighting individual choices and empirical studies focusing on crude aggregate variables. This project aims to enhance our knowledge in the field by contributing to the emerging topic of microeconomics of conflict notably by generating new data in India, a country regularly hit by outbreaks of low or moderate communal violence. In particular, I want to address three main questions: i) Who are the participants of violence ? ii) What socio-economic circumstances lead to violence ? and iii) What are the economic consequences of violence ? To do so I propose to make use of the most advanced tools of theoretical and empirical microeconomics for conflict analysis. I am especially interested in the relationship between household welfare and violence onset and consequences. The research design consists in matching information on geographic mapping of violence with household and community level data in Maharashtra. In addition, a field survey will be implemented in some of the selected communities both in the conflict-affected and the conflict-free areas. We intend to survey 1000 households in violent communities and 500 households in non-violent communities. For counterfactual purpose, those conflict-affected communities will be matched with comparable communities which have not been hit by violence. With these new data, it will be possible to identify victims and perpetrators of violence and to shed light on coping strategies used by vulnerable households and on characteristics of household and community that conduce to violence.

Keywords: social sciences,economics,applied economics,economics of development,development studies
A NOVEL BIOPROCESS COUPLING WASTEWATER TREATMENT WITH ELECTRICITY PRODUCTION TO REMEDIATE METAL POLLUTED AQUATIC ENVIRONMENTS (SEFCUMPAQ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 160028.45
EU funding (EUR): 160028.45
Participants: 1
Project status: CLOSED

Worldwide contamination of the aquatic environment with heavy metals (such as Fe, Co, Ni, Se, Zn, Pb, and Ni) and organic compounds has become a major concern, disturbing the natural functions of rivers/lakes and ponds, causing ecological and health problems. The microbial fuel cell (MFC) is a special form of a fuel cell in which bacteria catalyze the oxidation of organics and produces electricity. MFCs could provide an elegant novel ecotechnology, combining the clean-up of the pollutants (organic matter, metals or sulfate) with electricity production. This IEF will study a particular form of MFCs, that can easily be integrated in natural treatment systems: sediment fuel cells (SFCs). SFCs rely on the natural voltage gradient between the sediments and the overlying seawater. This gradient is created by microbial oxidation of subfloor organics, which results in the generation of electron-rich reductants such as Fe2+ or HS-. However, SFCs are still facing a challenge for consistent power production over extended periods. The composition, mechanisms involved in electroactive biofilms remained largely unknown and the potential of SFCs for metal polluted aquatic environments (MPAE) have not been explored yet. This IEF will develop a novel SFC, which will be tested on MPAEs, both polluted natural fresh and sea water. Thus, this IEF will contribute to the development of a cost effective alternative to current fuel utilization. The novel SFC will be evaluated as a function of organics/metals turnover and specific power production rates and in parallel, novel analytical techniques/methods to enhance/measure the biofilm activity (electrochemical). Finally, a prototype will be tested. This IEF will provide a tool and an instrumental role for water frame work Directive 2000/60/EC of the EU and Directive 2006/21/EC on management of industrial waste. This IEF falls into the category of renewable energy policy of EU, using sediment organic/inorganic pollutants as energy precursor.

Keywords: bioengineering,energy recovery,pollution,waste,disposal and ecotoxicology,biotechnology,metal pollution,ecology,biofilm,bioremediation,environmental chemistry,technological sciences.
Asymmetric endosomes in asymmetric cell division and tumorigenesis (ENDASYM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 180234.43
EU funding (EUR): 180234.43
Participants: 1
Project status: CLOSED

Recent Drosophila reports show that directional Notch signalling during asymmetric cell division is mediated by asymmetric endocytic trafficking. Unpublished data from the host lab showed that directional Notch signalling is initiated by the directed targeting towards the signal-receiving cell of specific endocytic compartments, the Sara endosomes, which carry the receptor Notch and its ligand Delta. I will combine automated quantitative analysis of the movement of these endosomes with an RNAi screen to identify cytoskeletal elements controlling Sara/Notch/Delta endosome dynamics. In vitro reconstitution of endosomal trafficking and biophysical micro-manipulation of these endosomes will unravel the fine molecular role of the machineries discovered in the screen. I will then study asymmetric endosomal dynamics in the stem cells of the fly brain in wild-type and tumorigenic conditions. The ultimate goal is to uncover the relation between endosomal dynamics, stem cell self-renewal and brain tumorigenesis.

Keywords: cellular and developmental biology,cytoskeleton,endocytosis,intracellular trafficking,asymmetric cell division,stem cell.
The evolution of post-orogenic landscapes: bedrock rivers, lithology and relief development (POSTOROLAND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

Post-orogenic landscapes occupy by far and away the bulk of the Earth’s surface but their evolution remains under-researched and poorly understood, providing the central motivation for this proposal. The principal outcome will be the testing of competing models for post-orogenic landscape evolution. The proposal is strongly linked to studies that analyse how climatic and tectonic factors influence landscape evolution, and relies on leading-edge techniques such as cosmogenic nuclide analysis and DEM analyses; the work will have important implications for the parameterisation of numerical modelling of landscape evolution. The project will combine digital terrain analysis, long profile analysis and cosmogenic nuclide analysis in the 20,000 km2 Lachlan River catchment, a bedrock river catchment draining the inland (western) side of Australia&apos;s southeast highlands on the 90 Myr-old Tasman continental margin. The Lachlan drainage basin is a classic post-orogenic landscape that has a very well-constrained Cenozoic evolution. The aim of the proposal is to assess the key controls on the rate and style of landscape evolution in this typical post-orogenic setting (1) by quantifying rates of landscape evolution, and (2) by assessing the ways in which landscape evolution is slowed by resistant lithologies. Thus, the research will provide an assessment of one of the major neglected controls of post-orogenic landscape evolution, namely, lithology. The role of lithology in landscapes evolution lies at the heart of some of the enduring questions in geomorphology, such as: Do hard rocks slow landscape evolution, and if so, how do they do this? Providing answers to these questions using the most up-date-date techniques of cosmogenic nuclide analysis and DEM analyses will help to bring the much-neglected post-orogenic terrains back into 21st century main-stream geomorphological research.

Keywords: tectonics,landscape evolution,bedrock rivers,knickpoints,topography,geomorphology,denudational isostatic rebound,landscape rejuvenation