Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic control of cell growth by mTOR in health and disease: a multi-disciplinary training (MENTOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Italy,Germany,Greece,Netherlands,Spain,Belgium,Switzerland,United States,United Kingdom,Poland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4189162.63
EU funding (EUR): 3953988.0
Participants: 26
Project status: SIGNED

MENTOR is a multi-disciplinary training network which focuses on the mTOR pathway, a central mechanistic hub that integrates nutritional cues and controls cell growth and metabolism. Aberrant activation of mTOR underlies monogenic diseases with broad spectrum of pathological manifestations, including tissue overgrowth, polycystic kidneys and neuropsychiatric disorders affecting around two million of people worldwide. To avoid the medical errancy of patients in different clinical departments and surgical mutilations, approaches of personalized medicine depending on the genetic landscape need to be implemented, taking advantage of suitable pharmacological products. The overall goal of the MENTOR research program is to: delineate molecular mechanisms of fundamental and aberrant mTOR functions, preclinically decipher the pathophysiology of mTOR, develop a novel arsenal of drugs to selectively target the pathway and provide proof-of-concept support for such interventions. This ambition can only be achieved by the multidisciplinary research program that MENTOR has conceived, through the training of a new generation of scientists at Graduate Schools of biology, pharmacy, chemistry or medicine that will become the leaders of mTOR research in both public and private sectors. MENTOR will establish a collaborative and efficient network from academia to industry, involving patient associations and clinicians with impact on scientific community and society.

Keywords: multidisciplinary,growth,genetics,mtor
Digital Glossary of Nuzi Hurrian (DiGloss)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

After centuries of research, scholars have deciphered most ancient Mesopotamian languages, but a few are still not fully understood. One of these last frontiers is Hurrian. The biggest problem for researchers today is that the meaning of many words is still unknown. The texts from Nuzi (c. 15th-14th BC, modern Yorghan Tepe, in Iraq) are key for the decipherment of Hurrian. They were written in a context of diglossia: by people who spoke Hurrian but wrote in Akkadian, and, as is usual in such contexts, Nuzian scribes used Hurrian loanwords. Although the Nuzi corpus is the largest of its kind, a systematic study of Nuzi Hurrian has never been undertaken. DiGloss aims to make a significant contribution to the comprehension of the Hurrian lexicon and bring the knowledge of this language to the next level. To achieve this goal, all Hurrian words in Nuzi texts will be compiled in an online database. I will apply an interdisciplinary methodology that combines contextual and morphological analysis to (1) understand how the scribes adapted the cuneiform writing system to record Hurrian and (2) determine the meaning of specific lexical items. The project will be based at Paris 1 University and will be supervised by Prof. Brigitte Lion, a world-leading expert in the study of Nuzi. Her expertise and the multidisciplinary environment at the host institution provide the ideal context for the development of DiGloss. The project will produce indispensable tools for future research in Hurrian, thus boosting my academic career. Clarification of the Nuzi Hurrian lexicon will bring us closer to the complete decipherment of Hurrian, and will allow scholars to fully understand texts that are only partially comprehensible today. As written texts are the cornerstone of the study of ancient historical societies, the results of the project will have an impact on Ancient Middle Eastern studies at large, while also contributing to the preservation of linguistic and cultural heritage.

Keywords: assyriology,cuneiform,ancient middle east,hurrian,akkadian,ancient languages,lexicography
A Blueprint for Photonic Quantum Computer (PhoQC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Canada
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 280751.52
EU funding (EUR): 280751.52
Participants: 4
Project status: SIGNED

Recent technological advances allow to build revolutionary devices for information processing by making use of the laws of quantum mechanics. Most strikingly, quantum communication allows to transmit information with physical security guarantees at rates exceeding the capacities of classical links and quantum computers provide a means to speed up certain computations solving certain problems faster than any (present or future) classical computer. One such problem is factoring large numbers into their primes. This problem is the basis of much of modern cryptography such as the security of any information transfer through the internet. But the factoring problem was shown to be efficiently computable on a quantum computer using Shor’s algorithm. A functional quantum computer would therefore jeopardize the security of the internet. Quantum computation with a discrete-variable system such as a two-level electron spin demands temperatures colder than those found in deep space. However, continuous-variable systems, such as photons (particles of light) can operate at room temperatures and are more robust against decoherence, allowing for full miniaturization and mass manufacturing. The theory of quantum error-correcting codes provides a new set of techniques to run a quantum algorithm with an arbitrary level of accuracy despite using imperfect noisy photons. Photonic quantum codes exhibit either translational or rotational symmetry in phase space. Potential of the latter has remained largely unexplored despite convincing evidence for a striking advantage. In PhoQC, I will develop a novel stabilizer formalism to systematically study rotational symmetry in phase space. I will find quantum codes operating on the entire or a part of the Hilbert space and I develop the corresponding universal logics. We are at the dawn of the quantum computing age and the quantum codes and techniques developed in PhoQC will bring (photonic) quantum computation closer to industrial deployment.

Keywords: bosonic error correction,continuous variable quantum computation,information theory
Personal and non-personal forms of address in three contiguous Romance languages: sociolinguistic approach and gender implications (DE-PERSONAlisation)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The proposed research project focuses on second-person address forms (e.g., ‘tu/vous’ in French) and non-personal strategies that avoid any reference to the addressee (e.g., impersonal constructions) in three contiguous standard languages: European Portuguese, Peninsular Spanish, and French from France and from Belgium. Address forms provide information about a number of features related to the interlocutors (age, sociocultural level, gender, etc.), the type of relationship they share (e.g., close friends vs. distant acquaintances), and their relative social roles (e.g., boss vs. employee). Therefore, analysing these forms may reveal social differences in terms of hierarchy or distance that show inequalities. In spite of the existence of relatively similar forms, due to their common Latin origin, the use of the address forms differs across the three languages. Indeed, the literature has not yet provided a full picture of the use of these forms because of their variability in speech and the many factors that influence which form is chosen. DE-PERSONAlisation aims to fill this void with an empirical approach based on a triangulation of methods and a combination of natural and elicited data from five different sources. The project seeks to establish for each language a sociolinguistic correlation (quantitative analysis) between the use of each form of address (including non-personal strategies) and the contextual and sociolinguistic variables of speakers and addressees, focusing on their gender, since little attention has been paid to this variable in research on these languages. Furthermore, concerning the non-personal strategies, an innovative pragmalinguistics study is carried out of which types are used (qualitative analysis) in relation with these variables. Finally, the project includes a multi-contrastive analysis between the three languages to show common and different patterns of use, focusing on the importance of the participants’ gender variable.

Keywords: corpus linguistics and communication
Explainable Trustworthy brain-like AI for Data Intensive Applications (EXTRA-BRAIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Sweden,Spain,Greece,Luxembourg,Portugal,Austria,Ireland,Italy
Call: Efficient trustworthy AI - making the best of data (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-02-28
Duration (months): 38.0
Total project cost (EUR): 4994312.5
EU funding (EUR): 4994312.5
Participants: 12
Project status: SIGNED

In parallel to the current developments in the so-called narrow artificial intelligence (AI) realm, there is an urgent demand for more universal, general AI approaches that can operate across a wider spectrum of application domains with varying data characteristics. It is expected that the emerging sustainable AI methods can be efficiently deployed in the edge-cloud continuum on different hardware platforms and computing infrastructure depending on the real-world task scenarios and constraints including the limited energy budget. In response to this growing demand and emerging trends we propose to adopt a brain-like approach to AI system design due to its promising potential for functional flexibility, hardware friendliness as well as energy efficiency among others. To this end, EXTRA-BRAIN is aimed at developing a new generation of AI solutions based on brain-like neural networks that enable us to overcome key limitations of the current state-of-the-art methods, exemplified by deep learning, such as limited cross-task generalisation and extrapolation to novel domains (bounded reliability), excessive dependence on costly annotated data as well as extensive training and validation processes with heavy demand for compute resources at high energy cost, to name a few. The core brain-like neural network design in our approach derives from the accumulated computational neuroscience insights into the brain's working principles of information processing, key learning schemes and neuroanatomical structures that underlie the brain's perceptual/cognitive phenomena and its functional flexibility. Furthermore, these novel models are supported by data optimisation pipelines, which improve data quality, security and reduce the costs of assembling suitable training data, and an explainability framework to empower the human user. The proposed EXTRA-BRAIN framework will be examined in a diverse set of use cases with different hardware demands in the edge-cloud continuum.

Keywords: brain like systems,neural networks,neuromorphic computing,data optimisation,edge cloud continuum,trustworthy ai,explainable ai
Blast Resistant Self-Centering Textile Reinforced Concrete Strengthening (BLASTEX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 319273.2
EU funding (EUR): 319273.2
Participants: 3
Project status: SIGNED

BLASTEX aims to jumpstart the development of self-centering (SC) reinforced concrete members that absorb blast energy with minimal damage, utilizing textile-reinforced concrete (TRC) strengthening layers for swift functional recovery. TRC layers dissipate energy through controlled crack formation in the cementitious matrix, while elastic textile reinforcement acts as a restorative spring, returning the structure to its original position after blast inertial loads are removed. While SC principles are well-established in seismic-resistant steel structures, their application in blast-resilient reinforced concrete remains unexplored. BLASTEX bridges this gap, leveraging SC to enhance blast resilience, eliminate the need for demolition, and reduce waste generation and associated emissions in new construction. During the outgoing phase at Virginia Tech (VT, US, 2 yr.), I will perform blast tests using the unique Shock Tube Laboratory, validate numerical models, and optimize SC design parameters. At Czech Technical University in Prague (CTU, CZ, incoming phase, 1 yr.), I will conduct numerical parametric studies and develop guidelines to facilitate SC implementation. At MOB-Bars (CZ, non-academic placement, 6 mo.), a start-up specializing in blast-resistant systems, I will examine SC protective design deployment in the commercial sector. With MSCA funding, I will benefit from three forms of mentorship: (i) close collaboration with Dr. Eric Jacques, a Shock Tube Laboratory director and expert on infrastructure resilience, blast protection, and energetic materials, (ii) academic leadership/research facility management training (Prof. Petr Konvalinka, former CTU Rector), and (iii) collaboration with Dr. Jindřich Fornůsek (MOB-Bars CEO). BLASTEX will facilitate two-way knowledge transfer across the Atlantic, enabling the researcher to find a future tenure-track position while honing his leadership/fundraising skills in blast research and the design of experimental facilities.

Keywords: blast loading self centering concrete strengthening of structures blast protection textile reinforced concrete shock wave loading shock tube finite element analysis
Solution for body kinematics monitoring (GESTUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: Italy,Spain,Greece,Belgium
Call: EGNSS - Transition toward a green, smart and more secure post-pandemic society (HORIZON-EUSPA-2023-SPACE, 2023)
Start date: 2024-10-01
End date: 2027-03-31
Duration (months): 30.0
Total project cost (EUR): 1764975.0
EU funding (EUR): 1362420.0
Participants: 9
Project status: SIGNED

Overall goal is to use GNSS as an support for IMU to track whole body movements in the wild, for healthcare and wellness applications. The GESTUS proposal aims to address a clear need of movement workers, physicians, physical therapists, and athletic trainers. The need is to have a tool that allows for highly accurate tracking of the kinematics of the human body, for the entire duration of the activity. GESTUS proposes a solution based on the integration of GNSS and IMU within ad-hoc wearable devices, which allow for high accuracy for a long duration of time in the real environment. The solution then consists of an ad-hoc created data processing algorithm and a cloud platform, with associated communication infrastructure, to automate sensor management, data downloading, processing itself, and results fruition, analysis and sharing. The project and the solution it proposes is primarily aimed at remote monitoring of patients with, or potentially affected by, degenerative and neurological diseases such as multiple sclerosis or Parkinson's. In such patients, it is very important to monitor with great accuracy the movements of every part of the body, both for possible early diagnosis and to monitor the evolution of the disease, to evaluate the effect of ongoing treatments, and to plan in advance actions to mitigate symptoms.

Keywords: imu gnss wearable remote assistance healthcare
TRUST AND PRIVACY PRESERVING COMPUTING PLATFORM FOR CROSS-BORDER FEDERATION OF DATA (TRUSTEE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Austria,Bulgaria,Spain,Italy,Romania,Finland,Luxembourg,Sweden,United Kingdom,Cyprus,Croatia
Call: Technologies and solutions for compliance, privacy preservation, green and responsible data operations (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-DATA-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 8706263.75
EU funding (EUR): 8706263.0
Participants: 22
Project status: SIGNED

As we live in a data-driven era, the emergence of interdisciplinary, geographically dispersed, data repositories, is inevitable. The fact that these repositories do not necessarily abide with existing interdisciplinary data representation standards, nor do they necessarily belong to any data federation initiative, renders them unusable, since researchers cannot easily access this data. Moreover, most of the times, integrity, privacy, and security in such interactions is either very difficult, or impossible to maintain. Towards this end, TRUSTEE aims to bring a green, secure, trustworthy, and privacy-aware framework that will aggregate various interdisciplinary data repositories, such as Healthcare, Education, Energy, Space, Automotive, Cross-border etc. and also consider other European data federation spaces and trans-national initiatives, such as Gaia-X and EOSC. TRUSTEE will offer a secure-by-design framework, wherein stored data is homomorphically encrypted, thus offering researchers i) ability to search and use data in the encrypted domain, ii) a unified and meaningful FAIR representation of data, in an open and fair manner, iii) complex and context-aware queries through advanced ontologies, iv) data processing and analysis through transparent trustworthy ML workflows, over an intuitive AI playground, which will promote AI eXplainability, interoperability, and re-usability, by utilizing state of the art methods and paradigms, v) compliance with European privacy and ethical frameworks, e.g., GDPR, PIA, etc., vi) enforce privacy by applying a Homomorphic encryption layer, through which all data interaction will take place, vii) a blockchain-based transaction recorder to ensure accountability. TRUSTEE's fully encrypted solution will be validated through six different use cases supporting GAIA-X, EOSC, EGI, etc. demonstrating a multi-disciplinary, Pan-European federated FAIR and private data ecosystem.

Keywords: homomorphic encryption,ssi,eidas,edge,ethics,trust,privacy,federated learning,sustainable data operations
Twinning for Promoting Excellence, Ability and Knowledge to develop novel approaches for targeting inflammatory and degenerative age-related joint diseases (TWINFLAG)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Lithuania,Ireland,Spain
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 4
Project status: SIGNED

TWINFLAG is an advanced research consortium consisting of top-class institutions in the field of extracellular vesicles (EVs), flow cytometry and biobanking. The main objective of TWINFLag is to improve capacities of IMC in Lithuania, to implement the excellence in translational research of arthritis treatment and extracellular vesicle (EV)-based biomarker development, innovation and research management. For this purpose, the consortium gathered leading academic institutions in the field of biomedical sciences from Ireland (UCD) and Spain (INIBIC) which will seek to raise the research profile of IMC. The consortium partners will share their knowledge during organized schools, short term visits and seminars, will implement a small scale research for a personalized therapeutic approach focusing on major research interests of IMC – degenerative and inflammatory arthritis. Currently available tools for the disease-modifying therapy of both rheumatoid and osteo- arthritis are not satisfactory, which is highly associated with the lack of specific and sensitive disease biomarkers. The need for the application specific disease biomarkers has been emphasized as they increase the success rate of drug development programmes and thereby accelerate the availability of new therapeutics. Partnerships that provide access to tissue banks, data, cell lines, biomarkers, patients and funding are essential for the development of novel therapeutics. Therefore, this three partner consortium identified the demand to develop an innovative joint-research strategy comprising application of novel therapeutics for arthritis, associated with the development of precision biomarkers for monitoring the efficacy of this treatment. The results of this project will contribute to increased attractiveness of IMC, retention of research talents and mobilization of national and European resources for strategic investments, as well as foster networking and business ideas.

Keywords: extracellular vesicles,degenerative joint diseases,cartilage,inflammation,flow cytometry