Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Compact REtrofit Advanced Thermal Energy storage (CREATE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Austria,Belgium,Poland,France,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Integrated solutions of thermal energy storage for building applications (H2020-EeB-2015, 2015)
Start date: 2015-10-01
End date: 2020-08-31
Duration (months): 59.0
Total project cost (EUR): 5380656.75
EU funding (EUR): 5380656.75
Participants: 17
Project status: CLOSED

The CREATE project aims to tackle the thermal energy storage challenge for the built environment by developing a compact heat storage. This heat battery allows for better use of available renewables in two ways: 1) bridging the gap between supply and demand of renewables and 2) increasing the efficiency in the energy grid by converting electricity peaks into stored heat to be used later, increasing the energy grid flexibility and giving options for tradability and economic benefits. The main aim of CREATE is to develop and demonstrate a heat battery, ie an advanced thermal storage system based on Thermo-Chemical Materials, that enables economically affordable, compact and loss-free storage of heat in existing buildings. The CREATE concept is to develop stabilized storage materials with high storage density, improved stability and low price, and package them in optimized heat exchangers, using optimized storage modules. Full scale demonstration will be done in a real building, with regulatory/normative, economic and market boundaries taken into account. To ensure successful exploitation, the full knowledge, value, and supply chain are mobilized in the present consortium. It will be the game changer in the transformation of our existing building stock towards near-zero energy buildings. WP1 Management,WP2 Cost Analysis and planning for future commercial products cost,WP3 System definition,design and simulation,WP4 Thermal storage materials optimization (key breakthroughs),WP5 Critical storage components and technology development (key breakthroughs),WP6 Thermal storage reactor design, implementation and test,WP7 System integration, experiments and optimization,WP8 Building integration and full scale demonstration,WP9 Dissemination and exploitation of results. CREATE will create viable supply chain by bringing together multiple scientific disciplines and industry. In other words, CREATE envisions a multi-scale, multi-disciplinary and multi-stakeholder approach.

Keywords: thermal energy storage,thermo chemical materials,solar,building environment,building integration,grid connection
Gut Microbiota in Nervous System Autoimmunity: Molecular Mechanisms of Disease Initiation and Regulation (GAMES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2022-05-31
Duration (months): 84.0
Total project cost (EUR): 1499946.0
EU funding (EUR): 1499946.0
Participants: 1
Project status: CLOSED

Multiple Sclerosis (MS), an autoimmune demyelinating disease affecting the central nervous system (CNS), causes tremendous disability in young adults and inflicts huge economic burden on the society. The incidence of MS is steadily increasing in many countries arguing for environmental factors driven changes in disease induction. How and which environmental factors contribute to disease initiation and progression is unknown. Using a spontaneous mouse model of MS, we have shown that the gut microbiota is essential in triggering CNS autoimmunity. In contrast to the mice housed in conventional housing conditions, germ free (GF) mice, devoid of gut bacteria, were protected from spontaneous experimental autoimmune encephalomyelitis (sEAE). Re-colonization of GF mice with a complex regular gut flora derived from specific pathogen free (SPF) mice resulted in sEAE within 2-3 months. The re-colonization also triggered pro-inflammatory T and B cell responses. However, colonization of GF mice with a reduced gut flora failed to induce sEAE during our observation period suggesting a “specific” rather than a “broader” microbial trigger. In this proposal, I want to study the role of gut microbiota in CNS autoimmunity with the following aims: Aim 1: CNS autoimmunity triggering/protecting gut microbes and host immune responses I want to study how and which gut bacterial species are modulating CNS autoimmunity to better understand the origin of autoimmune responses and their relation to host immune responses. Aim 2: Molecular mechanisms of sensing of gut microbiota and microbial metabolites during CNS autoimmunity I want to identify the molecular pathways that are involved in sensing the gut microbiota and its metabolites which are relevant to CNS autoimmunity. Aim 3: Therapeutic application of gut microbiota for CNS autoimmunity I want to identify therapeutic strategies targeting gut microbiota to limit the development of inflammatory processes during CNS autoimmunity.

Keywords: gut microbiota,experimental autoimmune encephalomyelitis,multiple sclerosis
Polymers in the Liver: Metabolism and Regulation (PoLiMeR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Germany,Germany,Ireland,Germany,Germany,Norway,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom,Luxembourg,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 4035403.66
EU funding (EUR): 4035403.66
Participants: 19
Project status: SIGNED

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational models fed with individual patient data, has the potential to provide the basis for a personalised diagnosis and treatment strategy. The PoLiMeR consortium (Polymers in the Liver: Metabolism and Regulation) has identified the inherited, liver-related diseases of glycogen and lipid metabolism as the ideal starting point for innovative research training in personalised ‘Systems Medicine’. Our perspective opens possibilities for the application of novel drugs and diagnostic tools to a range of both rare and frequent diseases. To advance diagnostics and treatment of metabolic diseases beyond the state-of-the art, a new generation of scientists is needed. The complexity of the metabolic network and its aberrant behaviour in disease require experts with a deep knowledge and understanding of Systems Medicine approaches. The lack of truly interdisciplinary researchers, trained in the three ‘pillars of Systems Medicine’ - experimental, computational and clinical research - severely hampers progress in this field. PoLiMeR aims to fill this gap and brings together clinical, academic, and industrial experts on inherited metabolic diseases, computational modelling of the entire human metabolism, organ-on-chip technology, and detailed metabolic profiling. Our mission is to train our Early Stage Researchers (ESRs) to become dedicated Systems-Medicine experts, who can seamlessly collaborate between computational and wet-lab environments, and between clinical, academic, and industrial environments. This training will enable them to become the future leaders in the field and eventually make the difference for the patients.

Keywords: systems medicine,inborn errors of metabolism,glycogen,lipids,liver,dynamic models,genome scale metabolic models,induced pluripotent stem cell,organ on chip,mouse models,proteomics,fluxomics
Powerfull Advanced N-Level Digitalization Architecture for models of electrified vehicles and their components (PANDA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Germany,Belgium,Romania,Romania,Romania,Serbia,Belgium,France,France,France,France,France,Netherlands
Call: Virtual product development and production of all types of electrified vehicles and components (H2020-LC-GV-2018, 2018)
Start date: 2018-12-01
End date: 2022-05-31
Duration (months): 42.0
Total project cost (EUR): 3488671.25
EU funding (EUR): 3488671.25
Participants: 16
Project status: CLOSED

To face the climate change, tens of millions of electrified vehicles need to be deployed in the next decade. To meet this challenge, the automotive industry must shift mass production from thermal to electrified vehicles. The challenge is further complicated by electrified vehicles having more components and architectures than thermal vehicles. Realizing this paradigm shift is only possible if there are innovative methods to significantly reduce their development and testing time. The main goal of PANDA is to provide a unified organisation of digital models to seamlessly integrate virtual and real testing of all types of electrified vehicles and their components. The complexity of developing electrified vehicles becomes manageable by delivering a modular simulation framework. Development partners can share models (in open or in black-box form), avoiding sensitive IP issues and greatly increasing the development flexibility. The proposed method will enable 1) an easy reuse of models for different development tasks, 2) a replacement of real tests by virtual tests and 3) real-time testing on vehicle level. This method will be integrated in a multi-power open platform based on existing industrial software, enabling Stand-Alone or Cloud Computing. The method will be validated using two existing vehicles (a BEV and a FCV). Also, real and virtual tests of the integrated electrical subsystems of an innovative P-HEV will be performed. PANDA will reduce the time-to-market of electrified vehicles by 20%, by harmonizing the interaction between the models. In addition, the seamless integration will give developers access to other subsystem models, which will decrease the correlation efforts on components by 20%. The open platform will 1) make it easier for OEMs, suppliers, SMEs and research institutions to interact and 2) enable a fair competition. These innovations will make the European market more flexible, more open to innovation and ultimately more competitive.

Keywords: electrified vehicles,model organisation,digital models,hardware in the loop,virtual and real testing,seamless integration
Future Secure and Accessible Rail Stations (FAIR Stations)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Italy,Austria,Spain,Belgium,France,United Kingdom
Call: Future stations and accessibility (IP1 and IP3) (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-09-01
End date: 2019-12-31
Duration (months): 28.0
Total project cost (EUR): 1199875.0
EU funding (EUR): 1199875.0
Participants: 12
Project status: CLOSED

Increasingly, railway stations are becoming complex, with some being interchanges, and in some cases commercial or shopping malls and social activities. Subsequently, there are likely to be issues with congestion, guidance and security that are not experienced in more remote stations. The FAIR Stations project aims to develop solutions for improved users flow within the station, and at the platform train interface (PTI). This will be done putting customer satisfaction, and security & safety at the centre of the station design, paying special attention to needs of PRMs. The project will conduct a study on the state of the art station designs, as a benchmark. Future stations design will hinge on three pillars: design for security & safety, design for congestion, and design for accessibility. Tools to be applied include: - User needs assessment - User flow modelling - Station design algorithm that optimises passenger flows for continuing and emerging operational design requirements such as security, baggage handling, and accessibility. - Engineering design of a train and/or platform based mechanism to facilitate independent boarding and alighting of PRMs, using sensors/detection systems. The key design factors to be considered are security, safety, baggage handling, ticketing, design for accessibility, information & signage, and climatology. KPIs developed will be used to evaluate and validated the design solutions. Since security is a major challenge highlighted, the station design process will incorporate a risk assessment sub-routine. As part of the demonstration, experimental and in-situ tests will be conducted. Additionally, a 3D virtual reality demonstrator will be developed. The outputs of the project will be aligned with S2R projects S2R-CFM-IP3-01-2017 & S2R-CFM-IP1-01-2017. The project consortium will include an academic institutions, rail operators, infrastructure managers, engineering SME, architectural firm, and passenger interest group.

Keywords: accessibility,reduced mobility,prms,crowd modelling,safety,security,travel experience,high capacity stations,plaftorm train interface,independent boarding,human behaviour,detection systems
Deciphering the host and microbial grounds that license inflammasome-mediated execution (INFLAME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1498799.0
EU funding (EUR): 1498799.0
Participants: 1
Project status: SIGNED

Inflammasomes are intracellular multi-protein complexes that play essential functions in immunity against microbial pathogens. Upon microbial sensing, inflammasomes induce protease caspase-1-dependent maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as gasdermin-D-dependent cell necrosis, namely pyroptosis. While both pyroptosis and IL-1β/IL-18 release play key parts in controlling microbial infections, the host-regulated pathways that promote detection of microbial ligands by cytosolic inflammasome-forming sensors and the non-canonical functions of inflammasome-derived components, remain to be fully characterized. Building on my expertise in the field of inflammasome regulators during microbial infections, I propose to study several key, yet unexplored aspects of the functions of inflammasomes in immunity from different angles. In particular, I propose to 1/ identify and characterize new host interferon-inducible factors that mediate microbial sensing by the inflammasomes, and 2/ unravel new non-canonical functions of inflammasome-derived proteases and gasdermins. To address these issues, I will use a combination of state-of-the-art and innovative technologies in biochemistry, molecular and cell biology, and immunology in various in vitro and in vivo models. For example, I propose to develop an unbiased genome-wide search for novel effectors involved in inflammasome activation based on the unprecedented coupling of the CRISPR-Cas9 technology to automated visual high-throughput screening. This multidisciplinary proposal will provide breakthroughs in the field of microbial pathogens detection by the host immune system, and will nucleate entirely novel immune paradigms on microbial sensing by new unsuspected host cytosolic proteins, namely the gasdermins. The results of this project will also provide strong bases for building innovative host-directed therapies for auto-inflammatory disorders and infectious diseases.

Keywords: inflammasomes,cell death,microbial sensing,gasdermins,alarmins,proteases
Towards a global database of sap flow measurements to unravel the ecological drivers of transpiration in woody plants (SAPFLUXNET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Plant transpiration is one of the main components of the global water cycle, and at the same time, water availability is one of the main abiotic factors limiting plant productivity, growth and survival. Hence, understanding the main environmental controls on tree water use is essential to address relevant questions posed by global change-related impacts on forest ecosystem services, including water availability and carbon sequestration. Sap flow measurements using thermal methods have now been applied to measure seasonal patterns in water use and the response of transpiration to environmental drivers across hundreds of species of woody plants worldwide, covering a wide range of climates, soils and stand structural characteristics. Here, we will design and begin to assemble a global database of sub-daily, tree-level sap flow (SAPFLUXNET) that will be used to improve our understanding of physiological and structural determinants of plant transpiration and to further investigate the role of vegetation in controlling global water balance. I will collectively analyse sap flow responses to environmental drivers, at time scales from daily to seasonal and annual, using statistical and mechanistic models of plant water transport. I will synthesise the database into a set of traits related to physiological regulation of transpiration. I will analyse these traits in their climatic and phylogenetic context and in relation to other drought tolerance traits. SAPFLUXNET is the first project designed towards a profound understanding of whole-plant transpiration regulation in woody species across the globe.

Keywords: drought,global change,plant functional traits,plant hydraulic architecture,sap flow,shrubs,stomatal conductance,transpiration,trees,water cycle
MUltiscale, Multimodal and Multidimensional imaging for EngineeRING (MUMMERING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Switzerland,Belgium,Sweden,Sweden,Sweden,Switzerland,Belgium,Hungary,Romania,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3993662.07
EU funding (EUR): 3993661.0700000003
Participants: 29
Project status: CLOSED

The overarching goal of MUMMERING is to create a research tool that encompasses the wealth of new 3D imaging mo-dalities that are surging forward for applications in materials engineering, and to create a doctoral programme that trains 15 early stage researchers (ESRs) in this tool. This is urgently needed to prevent that massive amounts of valuable tomogra-phy data ends on a virtual scrapheap. The challenge of handling and analysing terabytes of 3D data is already limiting the level of scientific insight that is extracted from many data sets. With faster acquisition times and multidimensional modali-ties, these challenges will soon scale to the petabyte regime. To meet this challenge, we will create an open access, open source platform that transparently and efficiently handles the complete workflow from data acquisition, over reconstruction and segmentation to physical modelling, including temporal models, i.e. 3D “movies”. We consider it essential to reach this final step without compromising scientific standards if 3D imaging is to become a pervasive research tool in the visions for Industry 4.0. The 15 ESRs will be enrolled in an intensive network-wide doctoral training programme that covers all aspects of 3D imag-ing and will benefit from a varied track of intersectoral secondments that will challenge and broaden their scope and ap-proach to research. The ESRs will exit the MUMMERING network as highly attractive and employable PhDs with a practical and qualified take on industrial research.

Keywords: tomography,4d imaging,high performance computing,electron microscopy,synchrotron radiation,x rays