Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fully Optimized Root of Trust for Robust Embedded Secure Systems (FORTRESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Germany,United Kingdom,France,Czechia
Call: Post-quantum cryptography transition (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 4987650.0
EU funding (EUR): 4987650.0
Participants: 8
Project status: SIGNED

The foundation of modern cybersecurity lies in the secure boot process, ensuring only trusted and authenticated software runs on a device. By validating code integrity through cryptographic signatures, secure boot upholds the Confidentiality, Integrity, and Availability triad, acting as the first line of defense against tampering, malware, and unauthorized changes. Currently, secure boot relies on traditional cryptographic algorithms like RSA. However, the advent of quantum computing threatens these systems, as quantum algorithms like Shor’s could break them, necessitating a transition to Post-Quantum Cryptography. The European Union and relevant agencies, such as ANSSI and BSI, advocate for a Post-Quantum/Traditional (PQ/T) hybrid cryptographic model, combining quantum-resistant algorithms with traditional cryptography for added resilience. Implementing quantum-safe secure boot remains challenging due to the performance, scalability, and compliance trade-offs of PQ/T solutions. However, to date there seems no significant progress has been made in this domain. FORTRESS aims to address these challenges by developing a scalable and efficient hybrid secure boot architecture. It will design a flexible Root of Trust, integrating both traditional and post-quantum algorithms while exploring trade-offs between security, performance, and cost. The project will focus on hardware-software co-design principles, enabling diverse platforms - embedded systems, edge devices, and Critical National Infrastructure - to transition to quantum-resistant architectures seamlessly. Additionally, the project will engage industry stakeholders to align with regulatory and standardization efforts, ensuring practical deployment and maximum impact. By developing a critical building block for a wide range of applications, FORTRESS will safeguard Europe’s digital infrastructure, fostering resilience and leadership in the post-quantum era.

Keywords: pq t hybrid,root of trust,secure boot,implementation security,hardware security
GENerative and connected intelligence for 6G Open ManagemEnt (GENOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Germany,Finland,Slovenia,Greece,Ireland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4881025.54
EU funding (EUR): 4258518.48
Participants: 12
Project status: SIGNED

GENerative and connected intelligence for 6G Open ManagemEnt (GENOME) research and training programme aims at investigating, developing/fine-tuning and validating large language models (LLMs) for the autonomous management and orchestration of various network technological domains (O-RAN, edge, cloud) through intent-based networking and task-agnostic network functions. It also targets the establishment of a connected intelligence framework for the coordination between these functions via on-the-fly protocol learning to mitigate conflicting management decisions and maximize utilization. Network configuration will also be generated automatically through innovative neuro-symbolic AI algorithms. Moreover, the transparency and resilience of the AI models is researched. All the developed components will be validated via both simulation and testbed experiments, and integrated into a final proof-of-concept. Besides, a detailed training plan is designed including schools, industrial days and soft-skills courses. It involves industrial partners to ensure that career perspectives of ESRs will be significantly increased by participation in the project. High quality dissemination and exploitation activities are also considered.

Keywords: 6g,edge cloud continuum,connected intelligence,generative ai,intent based networking,protocol learning,ran,resilience,transparent ai
Exploring the Molecular Properties of Atmospheric Freshly Nucleated Particles (ExploreFNP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1462491.0
EU funding (EUR): 1462491.0
Participants: 1
Project status: SIGNED

Aerosol particles are ubiquitous constituents in the ambient atmosphere. Ultrafine particles (< 10 nm) show adverse effects on our public health, as inhalation leads to an elevated risk of lung- and cardiovascular diseases. Aerosol particles also influence the global climate, by scattering sunlight away from Earth's surface and acting as seeds for cloud droplet formation. Combined, these effects lead to an overall cooling of the Earth, directly counteracting the warming effect of greenhouse gases. According to the IPCC, aerosol particles pose the largest uncertainty in global climate forecast. This uncertainty is caused by the lack of understanding of the early growth behaviour of small (< 3 nm) particles. The largest source of aerosol particles (50-90%) is from nucleation of vapours in the air leading to a burst of freshly nucleated particles (FNPs) of 1-2 nm in size. However, even the basic fundamental properties of these FNPs remain unknown and cannot be studied using currently available experimental techniques. I propose a unique approach to target the properties of FNPs by applying a versatile suite of computational methods, ranging from quantum chemical calculations to application of conceptually new machine learning models. The scientific objectives are: 1) To determine the chemical composition and stability of FNPs. 2) To understand how FNPs evolve over time via exchange of vapours with the environment. 3) To investigate how FNPs transform as a consequence of chemical reactions occurring at the surface or inside the particles. The research will provide unprecedented insight into the molecular level properties of FNPs. This project will directly supply input parameters (chemical composition, thermodynamics and kinetics) for atmospheric models, which are crucial in order to constrain the large uncertainty in climate predictions caused by small aerosol particles.

Keywords: aerosols,nucleation,clusters,quantum chemistry
Nanotherapeutic platform for lysosomal targeted technology (Nano-LYTAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-12
End date: 2028-01-11
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 2
Project status: SIGNED

Cancer remains a tough challenge, largely because 80% of cancer-driving proteins are considered “undruggable” meaning impossible to target with conventional therapies. Nano-LYTAC project brings together experts in nanomedicine, pharmaceutical technology, and nanotoxicology to answer the burning question: Does complete cancer eradication still remain as an elusive dream? By combining 2 cutting-edge technologies: “Smart Nanotechnology” and “Targeted Protein Degraders (TPDs)”, this project fulfills the goals of Europe’s Beating Cancer Plan by tackling these undruggable proteins. TPDs were created using Nobel Prize-winning bioorthogonal chemistry. Among these, LYTACs (Lysosomal Targeting Chimeras), with their ability to transport intracellular/extracellular cancer-driving protein for selective degradation in the lysosomes, abrogate the cancer pathology. However, despite their promise, LYTACs haven’t made it to clinical use yet, owing to challenges like limited molecule diversity, poor tumor penetration, low bioavailability, and metabolic instability. To transform LYTACs into clinically viable cancer therapies, and to overcome the aforementioned drawbacks, this project will use novel nanotechnological approach to enable enhanced tumor penetration, selectivity, protection, and controlled released of the LYTACs in tumor microenvironment. Moreover, for the first time, I will design new LYTAC molecules specifically targeting folate receptors that are overexpressed on many types of cancers (e.g.: breast cancers, lung cancer, ovarian cancers). At CATRIN, under the guidance of Prof. Kateřina Poláková, an expert in nanomedicine and their subcellular trafficking, and nanotoxicology, I will develop "Smart Nano-LYTACs" with the preclinical proof of their potential. This multidisciplinary project will also enhance my skills in nanotherapeutics and cancer biology, helping me to work towards my long-term goal of establishing my own research group focused on advanced cancer therapies.

Keywords: anticancer therapy,nanomedicine,bioconjugation chemistry,targeted protein degradation
Targeting cancer with mutanome based stem cell vaccine (MUTAVAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1809500.0
EU funding (EUR): 1782000.0
Participants: 1
Project status: SIGNED

The successful application of immune checkpoints inhibitors has modified the therapeutic strategies in several cancers but only 30% of patients will respond optimally to these therapies. One of the reasons for the failure of these therapies is the resistance of cancer stem cells (CSCs) leading to relapses long after the initial treatment. These cells are also resistant to conventional therapies via their quiescence and there are no targeted therapies available against them. The ambition of IPSIRIUS, a French biotechnology company, spinoff of INSERM and Paris Saclay University is to develop active cancer immunotherapy products based on the revolutionary induced pluripotent stem cell (iPSC) technology. IPSIRIUS developed first IPVAC, with the aim of leveraging patient’s immune system against a large panel of cancer antigens which are shared between iPSC and CSCs. With IPVAC, IPSIRIUS is developing a ground-breaking technology, having resolved all technical issues limiting cell-based therapies used for cancer. IPVAC is a safe, allogenic, off-the-shelf therapy, highly scalable using a versatile technology. This cell-based vaccination strategy showed efficacy in prophylactic and therapeutic settings against aggressive solid cancers with stemness features. The overall goal of the MUTAVAC project is i) to uncover the mechanisms of action of IPVAC, ii) to generate a highly immunogenic version of IPVAC, and iii) to design robust in vitro immunogenicity tests to predict immunogenicity of IPVAC and IPVAC-Mut in humans. With MUTAVAC project, IPSIRIUS will i) strengthen the scientific data on IPVAC to prepare its clinical development and leading to the open access publications and patents, ii) define a personalised medicine to propose efficient therapeutic cancer vaccine in patients with all HLA groups, iii) identify new targets for future cancer therapies, and iv) develop a technological platform to facilitate the development of the next-generation of cell therapies.

Keywords: induced pluripotent stem cells,cancer stem cells,immunotherapy vaccine
We care for those who care (CARE4CARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Poland,Belgium,France,Sweden,Germany
Call: Overcoming discrimination for an inclusive labour market (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2739011.25
EU funding (EUR): 2739011.25
Participants: 11
Project status: SIGNED

Care workers are mainly women and migrants, which makes the care sector an interesting field to verify the dynamics of segregation and exclusion that affect the labour market. At the same time, it is a challenging testing ground, which allows to design and verify new measures to contrast discrimination and promote social inclusion. EU institutions have included the care work sector among those sectors “key to the future of European society and economy”. The Covid-19 pandemic has made even more clear the centrality of care work in modern societies but it also made more visible many critical issues affecting the working conditions of care workers, such as: the lack of adequate economic resources, the workforce shortage, the pressure put on care workers, the risks for their well-being, the underfinancing of social care as a consequence of the reorganisation and partial retrenchment of the welfare state, the weaker bargaining power in the sector than in male-dominated sectors, the undervaluation of female-dominated jobs, the prevalence of undeclared work in domestic care work, patterns of discrimination in the sector on grounds of gender and nationality and the intersectionality between the two. This project proposal aims to investigate in a comparative and multidisciplinary perspective the working conditions of care workers and their perception of their working environment and dynamics and to develop suitable tools to improve job quality and contrast discrimination, such as: elaborating policy strategies to tackle the undervaluation of care work, with particular attention to the key role that trade unions, employers’ associations as well as equality and monitoring bodies can play; designing training programmes to empower trade unions and family associations and employers reps to improve job quality in the sector; setting up of a permanent observatory on care work, which will implement a platform accessible to care workers, in order to improve their rights’ awareness.

Keywords: care work,legal regulation,collective bargaining,discrimination,gender,migration,labour market inclusion,trade unions,families,employers,job quality,training,rights awareness,policies
Computational model predictive and adaptive control tools (COMPACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2499375.0
EU funding (EUR): 2499375.0
Participants: 1
Project status: SIGNED

Model predictive control (MPC) is applied with success in industry for automating constrained multivariable dynamical systems in an optimized way. However, some crucial aspects of MPC design largely remain to be addressed to unleash the full potential of MPC in applications: the efforts required to collect experimental data, identify the prediction model, and calibrate the controller, must be reduced considerably; the controller must self-adapt seamlessly to cope with unforeseen changes and not require excessively demanding computer hardware for deployment. This project aims to address methodologically such aspects and establish a theoretical and algorithmic framework for designing the next generation of nonlinear adaptive embedded MPC systems from data. Firstly, to reduce data-collection efforts significantly, we will develop tools that enable the design of experiments based on novel active-learning approaches to nonlinear system identification, coupled with robust MPC schemes to ensure safe data collection. Secondly, to cut calibration efforts down drastically, we will devise innovative preference-based methods that can learn from calibrators' assessments and automatically detect critical closed-loop scenarios. Thirdly, we will develop methods for seemingly adapting the prediction model at runtime to cope with uncertainties and model mismatches not seen during the design, as well as methods for approximating the control law with different tradeoffs between the amount of required online computations and the obtained closed-loop performance. To demonstrate the potential industrial use of the methodologies and algorithms developed in the project, we will formulate and solve laboratory benchmark problems on an experimental robotic platform, a challenging system for data-driven control due to its highly nonlinear, multi-input/multi-output, and fast-sampling dynamics.

Keywords: model predictive control,nonlinear system identification,active learning,recurrent neural networks,nonlinear programming,robot control
Marine climate change refugia fOr insulAr mesophotic ecosystems iN the south pAcific ocean (MOANA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

The mesophotic coral ecosystems are described as warm water light-dependent corals and associated communities inhabiting depths from 30 m to over 150 m in tropical and subtropical regions. These ecosystems present high ecological relevance as they can act as potential re-seeding areas for shallow ecosystems, harbor endemic and rare species, and provide suitable habitats to support the populations of many species of fishes and crustaceans. MOANA will address the knowledge gaps in how these ecosystems respond to climate-related stressors in the remote South-Pacific oceanic islands and seamounts by providing maps of future refugia and vulnerable areas for a selection of ecologically and socio-economically relevant species. The innovative approach envisaged in MOANA, using global high-resolution Earth System Model outputs, combined with Species Distribution Models, will provide essential information to assist in the implementation of adaptation and mitigation policies in South Pacific areas through the potential creation of marine protection tools as Mobile Marine Protected Areas and/or Blue corridors. Moreover, MOANA methodology and tools could be easily applied to assist other ecosystem preservation in similar areas, such as the Small Island Developing States (e.g., Caribbean Islands, North Pacific Islands), large-scale systems from the North Pacific (Marquise Islands- American Samoa - Hawaii - Japan), middle scale systems from the Atlantic basin (Azores, Madeira, Canarias) and even smaller scale systems from the Mediterranean (Baleares, Corse, Sicily, Cerdenya, Malta). Two leading Research Centers will be involved in the project, the Host Institution, the Barcelona Supercomputing Center (BSC, Spain), and the Ecology and Sustainable Management of Oceanic Islands, (ESMOI, Chile), a research center focused on biodiversity and local management of the southeast Pacific islands.

Keywords: biogeography,species distribution,benthic ecology,mesophotic communities,climate change
Innovative approach to an Individualised T-Cell Immunotherapy for cancer, using Personalised Tumour Trained Lymphocytes (pTTL) that is reliable, cost-effective, scalable and easy to implement (NEOpTTL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-11-01
End date: 2026-07-31
Duration (months): 33.0
Total project cost (EUR): 8422865.06
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

NEOGAP has developed a groundbreaking personalised adoptive T cell therapy for treating solid tumours based on two proprietary technologies: PIOR® machine learning software and EpiTCer®. This cancer immunotherapy consists of producing personalised Tumour Trained Lymphocytes (pTTL), which are autologous T-cells harvested from regional lymph nodes, subjected to a neoantigen-driven T-cell stimulation technology to deliver highly tumour-reactive T-cell clones (pTTLs). pTTLs are re-infused to the patient where they infiltrate and kill cancer cells, leaving healthy cells untouched. The therapy is broadly applicable to many cancer types, being personalised to each individual patient. In this EIC accelerator project, NEOGAP plans to complete the Phase 1b part of the first in human clinical trial of the therapy in advanced colorectal cancer patients, focused on safety assessment and biomarker exploration and optimise the manufacturing process for the next clinical studies.

Keywords: autologous immune enhancement therapy,adoptive t cell therapy,immunooncology,neoepitope,neoantigen,personalised cell therapy,cancer immunotherapy
CO2-free, on-demand, on-site production of low-cost green hydrogen produced with micro-wave plasma (South Beach)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-06-30
Duration (months): 33.0
Total project cost (EUR): 5435545.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

With a decentralised and scalable solution that produces carbon-free H2 on demand at a cost that is competitive with grey H2, SAKOWIN is at the forefront of the energy transition. SAKOWIN produces equipment (modules) that, using biomethane or NG as feedstock, produces H2 and solid carbon — both industrially valuable products. A big step forward from current and emerging solutions, our proprietary technology is distinguished by its competitive cost (1.5€/Kg H2 2025) —due to 5x less electrical consumption than water electrolysis— and by its CO2-free process, unlike steam reforming technology. Our technology brick will be installed where H2 is needed (fits into existing gas infrastructures), saving in storage or transport. Our focus is on equipment sales and licensing. We foresee revenues of €75M in 2030. With 276 modules in total delivered by 2030, by that year we envision SAKOWIN as a referent within the companies offering technologies to produce sustainable CO2-free H2.

Keywords: microwave plasma,carbon valorisation,plasmolysis,plasmalysis,green technologies,clean production,hydrogen production,green hydrogen,energy systems production,distribution,applicat,hydrogen,energy