Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Charles IV and the power of marvellous objects (POMOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2020-07-31
Duration (months): 18.0
Total project cost (EUR): 146591.1
EU funding (EUR): 146591.1
Participants: 1
Project status: CLOSED

The present study aims to investigate from a new perspective the collecting activities of Charles IV, king of Bohemia (1347-70), king of Romans (1346-78), and Holy Roman Emperor (1355-70). It proposes to go beyond narratives based on the nation-state and western-oriented research concepts, thereby renovating historical and artistic connections that national historiographies have obfuscated. In doing so, it will frame the topic trans-nationally. Rather than writing a large-scale synthesis based mainly on secondary sources, this research objective will be achieved by using a micro-historical approach focusing on a specific group of reused objects that are associated with Charles IV. At the centre of the project are Charles IV and the precious objects of diverse provenance which he acquired, assembled and commissioned to be adjusted. Being removed from the cultural context for which they were originally made and which determined their social values, the objects underwent, in different social and cultural contexts, transformation and subsequently integration with the new audience. They created multiple connections with the past and contributed significantly to the construction of the imperial self-image of Charles IV who was not only one of the most capable and effective rulers whom Europe had ever seen but also one of the greatest 'collectors' since the period of Classical antiquity.

Keywords: charles iv 1316 78,collecting,composite objects,treasuries,cultural interactions,art history,microhistory,cultural studies,european cultural heritage
Helicopter Engine Deck - Multifunctional layered insulation for CFRP fire and thermal protection (HEFESTO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Helicopter carbon composite engine deck (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2020-06-30
Duration (months): 21.0
Total project cost (EUR): 493375.0
EU funding (EUR): 425087.0
Participants: 2
Project status: CLOSED

The main objective of the HEFESTO project is to redesign the engine deck/firewall area of a helicopter in CFRP in order to obtain the greatest weight reduction possible (greater than 10%) and fatigue resistence improvement over the traditional titanium structure. In order for this to be feasible, the CFRP must be adecuately protected against heat and fire. The object of the HEFESTO project is therefore also to demonstrate a novel all-in-one multilayer coating effective to thermally isolate and fireproof CFRP in order to resist the operating conditions and fire hazards in the immediate area of a helicopter motor. The multilayer coating, which is composed of an aerogel (to thermally insolate), a ceramic (to fireproof) and an intumescent layer (to actively firefight), will be applied to the redesigned helicopter engine deck/firewall. The resulting structure will be fire tested to demonstrate it fireproof according to CS-29 standards, and also tested under constant temperature condicions representative of the motor area to demonstrate that the coating thermally isolates the CFRP at temperatures which are acceptable for this material to maintain its mechanical properties completely intact. The most appropriate configuration and application method for the mutli layer coating will be identified so as to make it practical, light, cheap and efficient.

Keywords: cfrc,engine deck,intumescent coatings,aerogels,fire proof
(Homological Projective Duality)-invariance of the Tate, Beilinson and Riemann conjectures (HPD-inv of TBR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This project will be carried out at the Warwick Mathematics Institute under the supervision of Prof. John Greenlees; I have worked for the past eight years at MIT and I will move in 2020 to the University of Warwick as an Associate Professor. Three of the most important conjectures in mathematics - the Tate conjecture, the Beilinson conjecture and the generalized Riemann hypothesis - concern the location and order of the zeros/poles of the L-functions associated to algebraic varieties. For example, in the particular case of an elliptic curve, the Beilinson conjecture reduces to the Birch and Swinnerton-Dyer conjecture, and in the particular case of a point, the generalized Riemann hypothesis reduces to the Riemann hypothesis. These are two of the seven Millenium Prize Problems. The first objective of this project is to prove that the conjectures of Tate, Beilinson, and Riemann, are invariant under homological projective duality in the sense of Kuznetsov. The second objective is to combine this invariance result with the different homological projective dualities in the literature in order to obtain not only a proof of the conjectures of Tate and Beilinson in numerous new cases but also an equivalence between the generalized Riemann hypothesis of very different algebraic varieties. These objectives will greatly improve the state-of-the-art of the Tate and Beilinson conjectures and will considerably deepen our understanding of the generalized Riemann hypothesis. In order to achieve them, I will combine Kontsevich's noncommutative viewpoint on algebraic geometry with mathematical tools from several different areas (e.g., algebraic topology, derived categories, algebraic K-theory, etc). This will enhance my creative and innovative potential, will foster my professional maturity and independence, will diversify my technical skills, and also will enable me to receive advanced training. Hence, this project is directly aligned with the MSCA-IF-EF-RI objectives.

Keywords: topological tate cohomology,derived category,algebraic k theory
Nanostar Sieving for Oligonucleotide Therapeutics (NANOLIGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Since the Nobel Prize winning discovery of small interfering RNA its specificity and selectivity have driven the pharmaceutical industry to design 15- to 25-mer oligonucleotide analogues as a new class of drugs. These offer exciting new therapeutic possibilities for example in rare diseases, but also large patient population indications including cardiovascular disease, and viral pandemics such as Covid-19. However, the high cost and limited scalability of manufacturing these complex polymeric molecules using solid phase synthesis is holding back benefits for thousands of patients – and has motivated us to seek an improved technology for oligo synthesis. ERC Advanced Grant 786398 is funding research investigating a new technology platform for the fabrication of defined monomer sequence polymers - Nanostar Sieving. Our preliminary research into oligo synthesis using Nanostar Sieving has found that it is potentially both feasible and game-changing. NANOLIGO seeks proof-of-concept that Nanostar Sieving can unlock the tremendous potential of oligos through dramatically reducing production cost and increasing production capacity. We will work with RNA oligos – key targets for novel APIs – which are currently produced by solid phase synthesis, and show that these can be made entirely in the liquid phase, with unprecedentedly high purity, efficient chemistry and lower solvent consumption. Crucially, membrane separations are readily scaled up, making this process a strong candidate for kg-scale oligo production. The PI and members of his research team have founded a start-up, Excatmer, to ensure the results of the ERC Grant have impact. We will carry out the PoC project at Exactmer, so that if we are successful the technology can be more rapidly developed and scaled up, leading to significant economic benefits. We are driven by a desire to make oligonucleotide therapies affordable and so available to patients as rapidly as possible.

Keywords: organic solvent nanofiltration,nanomembranes,defined polymer synthesis,oligonucleotide synthesis,molecular sieving,nanostar sieving
Reciprocal interactions between hypogonadism and epigenetic modifications: A path for the development of personalized treatments for depression (EstroGen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-14
End date: 2024-03-13
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: SIGNED

Major depressive disorder afflicts ~16% of the population and is a leading cause of disability worldwide. Classical antidepressants take weeks-to-months for clinical efficacy and only a sub-population of patients responds to treatment, highlighting the need for the development of novel rapid-acting and effective pharmacotherapies. Hypogonadism, the decrease in the production of gonadal hormones occurring due to ageing or several other medical conditions, has been associated with an increased risk for development of mood disorders, including depression. Accumulating evidence suggests that epigenetic changes induced by stress or other environmental factors might also contribute to the development of depression; however, the reciprocal interactions between hypogonadism, stress, epigenetic modifications and depression has received limited attention. During this project, my in-depth knowledge in studying the role of gonadal hormones in the pathophysiology of mood disorders will be combined with expertise of the Host lab in assessing epigenetic mechanisms of disease, to identify novel associations between hypogonadism and epigenetic modifications underpinning and/or predicting susceptibility for depression development. In particular, EstroGen proposes an interdisciplinary approach to investigate the combinatorial effect of hypogonadism/stress on epigenome and their role in depression, using preclinical models. In addition, this project aims to identify hypogonadism-related epigenetic biomarkers to predict subsequent development of depression. Importantly, this fellowship will propel my academic career and help me become a scientific leader at the interface of epigenetics, gonadal hormones and mood disorders, by acting as a stepping stone towards securing future research funding and acquiring a tenure track position in Europe.

Keywords: histone modifications,chromatin dynamics,gonadal hormones,hypogonadism,depression
MOTEG-Reimagining Mobility with worldwide highly innovative auxiliary components for commercial vehicles (comAUX)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Germany
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 2198875.0
EU funding (EUR): 1539212.5
Participants: 1
Project status: SIGNED

As a result of the global megatrend of e-mobility, there is a demand for highly efficient auxiliary units for braking and steering systems, as well as for example tipping devices of an excavator and the lifting platform of a truck for electric buses and commercial vehicles. Currently, this is causing massive disruption to automotive supply chains, while innovative solutions are lacking. State-of-the-art auxiliary power units were developed for fossil fuel engines and do not meet the requirements of the new mobility, especially in terms of operating performance, noise level and total cost of ownership. MOTEG has introduced an optimized set of innovative and unique auxiliary aggregates for electric buses and commercial vehicles. The development path for the aviation industry has enabled us to identify market opportunities in the automotive sector and to find synergies in an application-oriented product series development of electrical auxiliary units for commercial vehicles, the compAux series. This approach has enabled us to set new standards in technology and efficiency.Ouz aggregates occupy a third of the volume, half the weight and are with 68dBa noise level much quieter than all existing fossil-fuel powered competition products. The leading factor is the reduced energy consumption by a factor of 2 compared to the competition. MOTEG enables manufactures to produce electric vehicles with 10% longer range or 10% less investment in battery and reduced Total Cost of Ownership (TCO) by about 20 T€. Nevertheless, the price level of the MOTEG products is below the price of existing competition products. At the same time, we will expand our solutions to develop products for many other types of commercial vehicles, including construction machinery and agricultural vehicles. User acceptance will help us optimize our products and maintain traction for commercial success.

Keywords: electric,emission,city,pollution,particulate,matter,fine,particles,noise,cities,auxiliaries,electric drives
Artificial Intelligence RNA-seq (AIR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We propose a disruptive ICT concept strictly connected to SMEInst: Open Disruptive Innovation Scheme. In the field of genomics, sequencing technologies have drastically changed in the last few years and the output of complex data generated has outpaced the solutions available for analysis, integration and interpretation. RNA Sequencing has emerged as the number one technique in transcriptomics and thus the solution we propose is based on this. A.I.R.: Artificial Intelligence RNASeq is the first easy to use SaaS (Software as a Service) built with solid scientific methods. AIR is able to solve three important obstacles in the genomics field simultaneously: the informatics problem (specifically data storage, automatization of results and duration of analysis); the scientific problem (data interpretation and data integration, as well as providing new bioinformatic and statistical functions); the social problem (the lack of availability of skilled bioinformaticians). The overall objective of this project is to introduce a disruptive innovation that will allow researchers to perform transcriptomics data analysis easily, quickly and affordably. Given that AIR is already at TRL 7 of development, our specific objectives are to improve AIR’s current performance to take it to the final, gold TRL 9 stage and to carry out a feasibility study to launch AIR into the market. Economically speaking, we will assess if the investment required is sustainable compared to the expected market demand/ROI and quantify the upfront investment required to start a commercialization plan. We also need to evaluate the IP feasibility and assess the dissemination efforts required to successfully launch AIR into the market, and the organizational changes we must prepare for in order to sustain market demand. We are confident that AIR will change the paradigm of RNASeq data analysis. We also know that in order to achieve this quickly, we require a funding opportunity in line with the SMEInst budget.

Keywords: distruptive ict,rnaseq,genomics,transcriptomic,saas,cloud,software
Implications of Medical Low Dose Radiation Exposure (MEDIRAD)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radiation protection
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Spain,Ireland,Italy,Germany,Austria,Switzerland,Belgium,Greece,Poland,Sweden,Belgium,France,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: Impacts of low dose radiation exposure (NFRP-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2022-02-28
Duration (months): 57.0
Total project cost (EUR): 9995145.75
EU funding (EUR): 9995145.75
Participants: 37
Project status: CLOSED

MEDIRAD aims to enhance the scientific bases and clinical practice of radiation protection (RP) in the medical field and thereby addresses the need to understand and evaluate the health effects of low dose ionising radiation exposure from diagnostic and therapeutic imaging and from off-target effects in radiotherapy (RT). MEDIRAD will pursue 3 major operational objectives: First, it will improve organ dose estimation and registration to inform clinical practice, optimise doses, set recommendations and provide adequate dosimetry for clinical-epidemiological studies of effects of medical radiation. Second, it aims to evaluate and understand the effects of medical exposures, focusing on the two major endpoints of public health relevance: cardiovascular effects of low to moderate doses of radiation from RT in breast cancer treatment incl. understanding of mechanisms; and long-term effects on cancer risk of low doses from CT in children. Third, it will develop science-based consensus policy recommendations for the effective protection of patients, workers and the general public. Within the 4-year project a multi-disciplinary consortium will, in close interaction with European medical associations, MELODI and EURADOS (1), develop a tool to determine image quality to maximise optimisation of RP in medical imaging, (2) improve and develop new individual organ/anatomical structure dosimetry from chest CT, I131 administration, fluoroscopy-guided procedures, hybrid imaging, and RT for breast cancer and interlinks with image quality measures, (3) conduct epidemiological studies of consequences of RT and CT, (4) identify potential novel imaging and circulating biomarkers and mechanisms of radiation effects, (5) develop innovative risk models, (6) develop and implement for the first time a European repository of patient dose and imaging data, (7) develop science-based recommendations, and (8) introduce novel approaches to bring together the nuclear and medical sectors.

Keywords: cancer,cardiovascular effects,optimisation,radiation protection,patients,biomarkers,radiation sensitivity,radiographers
From flight mission planning for drones to 4D asset modelling (Drone Harmony)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current ecosystem of software for commercial drone usage suffers from the lack of automation. This renders many existing workflows in asset inspection, mapping/surveying & other drone usage scenarios prone to errors & not scalable. The most complex & least solved step in such workflows is drone-based data acquisition. At Drone Harmony we develop planning & flight automation software (mission planners) tailored for vertical inspection use cases, closing the data acquisition gap & guaranteeing a robust reproducible process. In contrast to existing products that apply manual & ad hoc approaches, our solution leverages existing data about the environment, including map information, CAD information, 3d models, digital elevation models & others to fully automate the planning process. This guarantees reliable data acquisition required for scalable drone-based inspections workflows. We automate the data acquisition process by making the software is aware of the asset & its environment complexity, process this information & produce optimal flight plans for drones to execute. Our mission planners have been installed on 30,000+ devices during the beta phase with 100s of users executing ~200 autonomous flights every day. We have already sold our missing planning software to 130 customers in 30 countries. Since the beta release of our mission planning software in Jul 2018, we are generating monthly revenues of €9,000+. The majority of the revenues come from sold licenses for which we have a retention rate of almost 100%. We have multiple sales collaborations with high profile partners, such as Bentley Systems, which gives us access to their sales channels & a large global reseller network. In this project we want to evaluate the market potential of a fully-fledged 4D modelling automated workflow solution for the enterprise market.

Keywords: 4d modelling,flight mission planning,asset management,asset inspections