Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the interaction network of the histone demethylase LSD1 in vivo (LSD1 IMPACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Each cell within an organism contains the same genetic information, however, only a specific subset of genes is transcribed in a given cell at a given time. This cell/stage specific transcription is controlled by the coordinated action of signaling pathways, chromatin associated proteins and transcription factors. Defects in chromatin organization and gene expression due to aberrant activity of chromatin modifying enzymes can contribute to diseases such as cancer. Since its discovery, the histone demethylase LSD1 has emerged as a key chromatin regulator. Several studies have implicated LSD1 in tumorigenesis and there is a growing interest in its use as a drug target. However, we still have a limited knowledge of LSD1 pathway-specific functions and a genome-wide study of its role in a whole organism is lacking. My strategy is to use an animal model system, Drosophila melanogaster, to dissect LSD1 function in vivo. My work has shown that mutation of LSD1 Drosophila ortholog, dLsd1 impacts specific developmental processes. Taking advantage of the tools available in Drosophila, I discovered a surprising antagonism between the histone H3K4 demethylases dLsd1 and Lid at chromatin boundaries and an involvement of dLsd1 in the Notch signaling, which we found to be conserved in mammals. To identify novel pathways involving dLsd1 in vivo, my lab is carrying out a genome-wide RNAi screen in Drosophila. We plan to study how dLsd1 and key candidates discovered in the screen control gene transcription and chromatin homeostasis in specific developmental contexts. We then plan to take a few new key interactions and to test whether this newly acquired information is conserved in mammals and can be exploited to target tumor cells. The goal is to provide insights into the LSD1 network of interactions, which will be instrumental for understanding the mechanisms that control chromatin structure and gene transcription and how their deregulations leads to diseases such as cancer.

Keywords: chromatin,histone demethylation,transcription,drosophila,cancer
Computational Modelling and Design of Sustainable Catalysts for Water Oxidation (COMPUWOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-02-01
End date: 2018-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The project focuses on the application of computational chemistry to the design and modeling of sustainable catalysts for water oxidation. This is a key technology for the development of solar fuel devices, which, thanks to the production of hydrogen from water and sunlight, will reduce the present dependence on oil and gas supplies. The project is targeted at the main challenges of water oxidation catalysis: high activity, robustness, sustainability and modularity. A group of known catalysts, some of them assembled to photosensitizers, will be studied in detail by using state-of-the-art methods. These include DFT and TDDFT methods used in combination with implicit and explicit solvation models. Advanced tools like the AFIR (Artificial Force Induced Reaction) method and linear-scaling DFT calculations on large molecular systems will be also used. The reaction mechanisms will be determined for both productive and unproductive (deactivation) pathways. The excited states and the UV-VIS spectra of the photosensitizers attached to the catalysts will be also explored. The knowledge acquired in these studies will be exploited to design catalysts showing higher performance. These new systems will be tested in silico and developed in the laboratory by means of collaborations with experimental groups. The project funds will be used to provide the applicant with a researcher contract of four years. This will guarantee the execution of the project and improve the permanent integration prospects of the researcher at the host institution.

Keywords: catalysis,theoretical and computational chemistry,transition metals,homogeneous catalysis,water oxidation,photosensitizers,reaction mechanisms,dft,tddft,qm/mm,mecp,linear scaling
Nutrition and Bladder Cancer (BLADDER CANCER EPID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

During the last decade I have built a research line on bladder cancer epidemiology with a specific emphasis on diet. This has led to 54/150 publications on this topic. Although, the literature is sparse, my team and others have concluded that some micronutrients in the diet such as vitamins C, E and selenium may play a preventive role in bladder carcinogenesis. We are currently pursuing this lead with two chemoprevention clinical trials, two case-control and one cohort study. Although other food products have been researched, so far the results remain inconclusive. Our 2008 expert report for the World Health Organization concluded that the accumulated evidence on the association between specific foods, nutrients, dietary patterns and the risk of bladder cancer is still weak. This is surprising as diet is expected to play an important role in carcinogenesis because the bladder is an excretion organ. The most likely reason for this is that most previous studies have had insufficient sample size and thus lacked adequate statistical power for analyses on 1) individual food items instead of the more common but less detailed food groups, 2) for subgroup analyses and 3) for food-food interactions. The proposed research brings together the world’s data on diet and bladder cancer. In a unique collaboration, researchers from 26 case-control studies and 15 cohort studies across the world have agreed to share their nutritional data with over 30.000 participants including over 10.000 bladder cancer patients. The project aims to provide definite answers on which individual food products, nutrients, existing diets (both regionally and culturally defined) and adherence dietary recommendations could influence bladder cancer risk. In addition, contemporary principle components and machine-learning algorithms will be used to identify novel explanatory dietary patterns. The results will be used to update existing dietary recommendations for the prevention of bladder cancer.

Keywords: bladder cancer,epidemiology
Identification of vaccine candidates using reverse vaccinology (REVVAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: TERMINATED

Reverse vaccinology (RevVac) is an emerging field that uses bioinformatics to identify vaccine candidates directly from the genome sequence of pathogenic bacteria. The long-term goal of the proposed research is to identify new vaccine candidates that may be formulated into subunit vaccines that protect against bacterial pathogens. The objective of this particular application is to dramatically improve upon methods of RevVac developed in my laboratory. The central hypothesis is that my RevVac procedure will be enhanced by building larger training data sets, incorporating new protein annotation, assessing multiple machine learning methods, investigating additional validation techniques, and by facilitating open access to predicted vaccine candidates to the vaccine community through the Bacterial Protective Antigen Database (BPAD). Guided by published preliminary data in the journal Vaccine, my hypothesis will be tested by pursuing the following objectives: (1) To improve the prediction of vaccine candidates, (2) To understand what makes a bacterial protein a good vaccine candidate, and (3) To create a vaccine resource for bacteriologists. The rationale for the proposed research is that once there is high confidence in predicted vaccine candidates, then only a small number will need to be tested in animal models in order to identify those with protective effects that can be formulated into subunit vaccines. This proposal is responsive to the objectives of the work programme since it will establish my novel research talents and knowledge with respect to reverse vaccinology and gene expression biomarker analysis in the EU. In addition, I will bring a plethora of longstanding collaborations solidified while working in the USA. Finally, the University of Southampton is fully committed to my long-term EU integration vaccinology (RevVac) is an emerging field that uses bioinformatics to identify vaccine candidates directly from the genome sequence of pathogenic bacteria.

Keywords: l201 genomics - comparative genomics - functional genomics,l210 bioinformatics,l602 adaptive immunity,l609 bacteriology,l611 prevention and treatment of infection by pathogens
Steady-state entanglement with superconducting qubits (SUPTANGO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-09-01
End date: 2018-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Quantum entanglement is the key resource that makes quantum information-processing machines more powerful than classical ones. In this project in quantum-mechanical engineering with superconducting qubits – electronic circuits that are engineered “artificial atoms” – I will create quantum-entangled steady states that never decay, as long as the qubits are subject to external microwave drive fields. I will do this by designing the driving protocol and the qubits’ dissipative environment – “quantum bath engineering” – in a circuit-QED architecture with carefully designed qubit-resonator couplings and resonator loss rate. The dominating transition rate can then act to prepare the system, rapidly and with high fidelity, in the desired singlet as a steady state of the dissipative time evolution. This is a new concept: only very few related experiments have been done with other physical systems, and none with superconducting qubits. Compared to the standard way of preparing entangled states – by one- and two-qubit unitary gate operations – this scheme has several advantages, chiefly the resilience to energy relaxation of the qubits because the induced transitions and the relaxation processes bring the system back to the desired state. I already have preliminary and promising results in this project, and good international collaborations. The excellent infrastructure and great environment at Chalmers University will help me succeed, which in turn will ensure my integration into the European research community. This research field is internationally very competitive, in particular as superconducting qubits are emerging as the perhaps most viable type of system to base future quantum computers and quantum simulators on. It should therefore be a strategic interest for the EU to continue being on the forefront in quantum technologies.

Keywords: entanglement superconducting qubits resonators quantum computing simulation parametric oscillator
Risk Estimation of Rocking Components Subjected to Ground Motions. (RERCSGM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This Career Integration Grant will support me during my transition from a postdoctoral scientist in Columbia University in NYC to a University Lecturer at the University of Oxford. It will allow my proper reintegration to Europe, since I originally come from Greece but have been studying in the US for the last 5 years (4 years PhD -1 year Postdoc). Success within the targets of this CIG project will allow me to become a permanent Lecturer at the University of Oxford after 5 years and hence a permanent member of the ERA. The CIG will provide me with substantial research budget that will also allow me to attend several conference and disseminate my work as well as creating collaborations within the European and international research communities. Below follows a short description of the project: A wide range of structural and non-structural elements are not tied or bolted to their support medium and thus are free to experience large displacements and rotations when subjected to ground motions. Their response is in general a three dimensional motion where rigid body modes such as: sliding, bouncing, spinning and swiveling (when casters are used) and rotating with respect to a vertex of the body may dominate the response to a lesser or greater extent, depending on the properties of the body, its support medium and the ground motions characteristics. This rich non-linear 3D response may overall be characterized as rocking. This research will develop new models that accurately describe the behavior of rocking objects, quantify the associated risk and suggest solutions to minimize it.

Keywords: rocking,risk,structural elements,non-structural elements,ground motions,seismicity,sliding,casters,impacts,3d lagrangian dynamics,dem,data fusion,ukf
Metal-mediated Ring-opening Polymerizations: New Monomers, Catalysts and Materials (MMROP-NEWMAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Polyesters represent one of the most important classes of polymeric materials, providing essential feedstocks for commodity products, medical devices and specialty polymers with tunable properties. Our current efforts focus on the development of polyesters derived from renewable resources, specifically targeting polymers with both microstructure and macrostructure control. We design catalysts that mediate the ring-opening polymerisation of cyclic esters for this purpose. By designing monomers, reactions and catalysts we can generate biodegradable and bioassimilable materials, many of which are new and may have unprecedented properties as functional materials. In all cases, we modify polymer stereoregularity to further tune the thermal properties, degradation rates and self-assembly of our materials. Specific research goals for this transitional grant are as follows: (1) Tacticity and an Expanding Monomer Scope. We will combine our expertise in the ROP of cyclic esters with our understanding of catalysis and ligand design to expand tacticity control to new monomer classes including (i) cyclic morpholinediones to afford poly(depsipeptide)s, cyclic phosphate esters to afford degradable flame retardants and β-butyrolactone derivatives to afford biodegradable thermoplastic elastomers. (2) Functional materials. We will synthesize new-to-the-world materials, with a particular focus on controlling under-exploited monomers, is essential to expanding the scope of green materials. We will develop novel hyperbranched polyesters, hydroxy-functionalized degradable materials and multi-functional materials prepared through immortal ring-opening (co)-polymerisation and olefin metathesis. (3) Catalyst design. We will design new catalysts capable of mediating these challenging reactions, with a particular focus on increased monomer scope. Anilido-aldimine, phosphinimine, salen and salan frameworks supporting iron and aluminium catalysts will form the foundation of these efforts.

Keywords: che (chemistry),c139 polymer chemistry,c126 new materials,c112 catalysis
Who and What is the Middle Class (WWMC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The middle class attracts much attention in recent years, but little is known about who and what is (in the) middle class. We use new institutional social sciences theory and state of the art latent class analyses to answer both questions. We argue that what defines the middle class are institutions that protect access to education, health care, asset accumulation, descent income and personal safety. These are necessary conditions for being a productive member of the middle class. While poverty often ensues off a deficiency in one of those conditions, the very rich can probably forgo them. We use latent class analyses to learn the level of protection one needs to become a member and at what level of affluence can one afford to forgo these protections. Pilot studies demonstrated the feasibility of the project. We want to use larger data sets of different EU and OECD countries to study determinants of middle class membership in a cross geographies, time series. Our study will yield important information on what policies could strengthen the middle class. For example, the Achilles Heel of the U.S. middle class is access to health care. Health insurance is provided through employers, so if you lose your job you lose your health care coverage and a slippery slope to poverty ensues. About six million Americans lost their middle class status since 2007-8. They lost assets, jobs and health care, but the latter was the most significant in reducing Americans to poverty. We estimated that two millions regained the status with the enactment of Obama’s Affordable Care Act allowing parents to keep off-spring on their insurance policy until the age of 26. European countries have universal health care but the middle class is more vulnerable to unemployment swings. The ‘short work time’ program in Germany has been effective in helping Germans keep their middle class status. Our study will allow scholars and policy makers to sort out specific vulnerabilities of the middl

Keywords: middle class,property rights,new institutional social sciences,assets,income,health care,education
Perturbations in Flocking Systems (PIFS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Flocking, the collective motion displayed by large groups of birds in the absence of a leader, is one of the most spectacular examples of emergent collective behavior in nature. Flocking is not only restricted to birds but can be observed in an extremely wide range of active matter systems – systems composed by “active particles” able to extract and dissipate energy from their surroundings to produce coherent motion -- as diverse as fish schools, vertebrate herds, bacteria colonies, insect swarms and active macromolecules in living cells. While our knowledge of collective motion has greatly advanced in recent years little is known concerning the response of moving groups to perturbations, a question of both theoretical interest (fluctuation-response in out-of-equilibrium physics) and of great ethological importance (biological significance of group response, spatio-temporal mechanisms of information propagation in cases of alert). Protection from external threats is thought to be one of the most important factors in the evolution towards collective behavior, and there is indeed evidence that certain collective properties observed in animal groups cannot be understood in the context of unperturbed theories. Experimental observations in starlings, for instance, have revealed that flocks are much more internally correlated, and thus have a more efficient collective response mechanism than expected from standard unperturbed flocking theories. Our working hypothesis is that certain properties of collectively moving animal groups can only be understood in terms of the system response to localized, dynamical perturbations. We will characterize the response of flocks to such perturbations, devoting particular attention to the role of information transmission from the boundaries to the bulk of a finite system. We will consider finite perturbations, but also the limit of infinitesimal perturbations, which may allow for a deeper theoretical analysis of linear response.

Keywords: active matter,flocking,response to perturbations,animal group behavior