Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mimicking Bacterial Middle Ear Infection in the Lab (MIDEARI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2027-07-31
Duration (months): 49.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Bacterial infections in the human body mostly involve biofilms - locally dense populations of bacteria that are extremely difficult to treat with antibiotics. Understanding antibiotic-biofilm interactions is crucial if we are to design better antibiotic treatment regimes to avoid the emergence of antibiotic resistance. In biofilms, bacteria are surrounded by a biopolymer matrix which can inhibit the motion of antibiotic molecules, leading to complex diffusive behaviour. Yet it is not known how these biophysical matrix-antibiotic interactions influence bacterial killing in a spatially complex infection model. Answering this question is the objective of my proposal. I will set up a lab model that mimics Acute Otitis Media -bacterial infection of the middle ear- and I will use advanced microscopy methods to track antibiotic molecules as they interact with bacterial biofilms. I will answer the following questions: A) what is the spatio-temporal distribution of antibiotic molecules in the biofilm? and B) What is the effect of biofilm structure on the antibiotic response, at the single-cell level? After establishing materials and protocols (objective 1), I will use fluorescence-correlation-spectroscopy (FCS) to characterize the spatial distribution of antibiotic molecules (objective 2). Next, I will use state-of-art 2D STED-FCS method (combination of FCS with stimulated-emission depletion microscopy) to track in unprecedented detail how antibiotics kill individual bacteria within a biofilm (objective 3). Finally, by tracking bacterial growth over long times, I will determine how antibiotic resistance emerges in these spatially complex biofilms (objective 4).

Keywords: bacterial middle ear infection mimicking antibiotical therapy in middle ear
ZOF: Zona Franca – Ideas of Territory in the Carolingian Empire (ZOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

The project ZOF: Zona Franca – Ideas of territory in the Carolingian Empire will investigate and visualise early medieval ideas of territory, specifically in the south-eastern regions of the realm. ZOF will use a new and unique two-part approach: firstly, investigating early medieval source texts using theories of critical and discourse theories as well as cultural geography, and, secondly, applying techniques and methods from digital humanities, critical geography, and GIS to analyse the sources and visualise the research findings. This will permit a fresh view on early medieval territories and territoriality as represented in the written sources. One important step towards this is the inclusion of spatial narratives and terms that hitherto were cast aside as ‘not plausible’. All early medieval discourses on territory in the broadest sense will be included in ZOF. The resulting data will be stored in an open-access database and visualised in an interactive map application: ZOF-MAP. This application will use new and more accurate methods of visualising medieval territories than traditional historical maps or GIS: ZOF will be using methods of critical cartography, mental mapping, and deep mapping. As an open access online application, ZOF-MAP will reach a wider public and thus give a broader audience access to cutting edge historical research.

Keywords: early medieval history,digital humantities,spatial history,historical geography,historical gis,territory and territoriality
Self-assembled liposomes functionalized with transition metal-based photocatalysts as a supramolecular platform for efficient photocatalytic water splitting (Lipo4AP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Artificial photosynthesis is aimed at developing photocatalytic systems that convert solar energy into chemical energy carriers such as renewable hydrogen. These artificial systems draw inspiration from natural photosynthesis which takes place at the core of lipid membranes. The artificial lipid membranes of liposomes hence hold strong potential for designing visible light-driven water splitting supramolecular systems. However, it remains a photochemical challenge to couple the two half redox processes that altogether form water splitting: water oxidation and water reduction. In this project, we use bioinspired, supramolecular photocatalytic assemblies supported on the membrane of liposomes, to realise such coupling. Liposomes provide nanocompartments to confine reaction spaces and enable vectorial charge transport. Amphiphilic transition metal-based photosensitizers and molecular catalysts will be anchored to the lipid bilayers, facilitating the concomitant evolution of O2 and H2 from the two half-reactions. To couple both half-reactions, will use an hydrophilic cobalt cage complex as reversible electron relay. The project has been structured to realise key operations: light harvesting, charge separation, directed proton and electron transport from the water oxidation side to the proton reduction side, ultimately achieving water splitting via a Z-scheme mechanism. The study will focus on assessing the coupling of two redox processes by optimising pH and minimising charge recombination on both sides of the photo reaction. The successful implementation of Lipo4AP could lead to innovative strategies for the next generation of biomimetic artificial photosynthetic systems. The complementary advanced skills obtained by the fellow will complete her prior expertise to successfully advance her research career dedicated to catalytic transformations of small molecules, which are relevant to the economic and environmental targets of the European Green Deal.

Keywords: coordination chemistry,biomimetic chemistry,self assembly,lipid membrane,photosensitizer,redox mediator,photocatalytic water splitting,hydrogen evolution,artificial photosynthesis,solar fuel
The Jesters as Artists. Exploring the Role of Jesters in Early Modern European Culture (JestArt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1474565.0
EU funding (EUR): 1474565.0
Participants: 1
Project status: SIGNED

This project seeks to pioneer a groundbreaking, fresh, and inclusive perspective on European cultural heritage history from the perspective of the jester. By exploring the lives of jesters—who they were, why they have been marginalized in traditional cultural histories, and the profound influence they wielded in the arts—this study will uncover their overlooked role and reshape our understanding of entertainment and artistic expression in European history. The project is structured around three primary objectives: i) To understand what it meant to be a jester in Early Modern Europe, focusing on their professional and cultural profiles, socio-economic conditions, abilities or disabilities, and their specialized skills. It explores who their patrons were, where they performed, and how they were recognized. The research examines the various paths jesters took to court life and their living conditions. ii) To investigate the long-standing exclusion of jesters from cultural heritage, hypothesizing that rivalry between jesters and artists played a role. As artists became organized in academies, they gained status, sought patronage, and pushed jesters to the margins of courtly life, caricaturing them into grotesque figures. The research explores how the institutionalization of art impacted jesters’ roles, their diminishing presence at court, and their evolution into caricaturesque characters in theater, literature, and the visual arts. iii) To reevaluate jesters’ productions as a forgotten artistic canon. Jesters, often educated and integrated into courtly life, contributed to various forms of entertainment, including writing, performance, music, and dance. The project questions how they influenced artists and contributed to a broader canon that enhances our understanding of early modern desire for wonder.

Keywords: jester,fool,dwarf
Moralizing Politics: The Practice of Judging Others (MoPo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499678.0
EU funding (EUR): 2499678.0
Participants: 1
Project status: SIGNED

Key developments in contemporary politics share a tendency of moralization. People moralize politics when they judge each other and assess them as good or bad people. A moralizing politics of judging others and a counter-politics of reacting to being judged can be found in phenomena such as cancel culture, esteem of work, accusations of fake news, and climate shaming. The existing literature tends to focus on the detrimental effects of using moral language in politics, for example, as a catalyst of polarization. MoPo takes a step back and seeks to understand the meaning and value of social practices of moral responsibility ascriptions. The idea is that moralized politics must be approached as having roots in people’s deep and ineradicable concern with how they are regarded and treated by other people. Moreover, judging others is not only something we cannot stop doing as human beings but also integral to the democratic ideal. Democracy is an ideal for how citizens should regard and hold each other mutually accountable. Judging others is necessary to demonstrate commitment to and upholding this ideal. At the same time, judging others can create unproductive hostility and make people feel inferior. The challenge that MoPo addresses is to understand when the human propensity to judge others is pernicious versus beneficial for democracy and to answer how we can transform it into a resource that strengthens democracy. The project does so through a research design that combines insights from moral and political philosophy and four case studies of moralizing politics (Cancel Culture, Dignity of Work, Fake News, and Climate Shaming). MoPo breaks new ground by comprehensively rethinking the idea of moralizing politics, creatively integrating philosophical analysis and research into practices of moral judgment in different areas and arenas, and by theorizing how practices of judging others can be channeled into improving (rather than undermining) democracy.

Keywords: moral philosophy,ethics,deliberative democracy
OMNISCOPE Hop On Application to join Yellow4FLAVI (Yellow4FLAVI Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Malta
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 593765.0
EU funding (EUR): 593265.0
Participants: 2
Project status: CLOSED

While endemic to the tropics, flaviviruses like Zika, dengue, West Nile or yellow fever virus are re-emerging pathogens of global health concern. Climate change and urbanization have largely contributed to the dissemination of their mosquito vector and Europe has in recent years been regularly confronted with autochthonous cases. Few vaccines are licensed to prevent flavivirus disease, but the yellow fever 17D (YF17D) vaccine has a unique track record of efficiency and safety. Intriguingly, despite its success, how YF17D induces immunity remains poorly understood. Yellow4FLAVI aims to fill the gaps in our understanding of the mechanism of action of this vaccine by linking the structure of the viral particle to the resulting host immune response, in order to learn about optimal vaccine design for flaviviruses in general. Since social acceptance of vaccines is critical for their success, we will also develop optimal communication methods. This will provide us with the tools to tailor vaccine design not only to achieve optimal immune protection, but also to facilitate actual implementation. The Yellow4FLAVI Hop-On Project builds and expands on this original effort by integrating Omniscope's state-of-the-art single-cell T and B cell receptor sequencing technology. Omniscope's involvement will leverage its proprietary technology to analyze vaccination samples, generating a significantly larger and more comprehensive dataset than initially envisioned. This expanded dataset will provide a broader foundation for analysis and modeling, potentially uncovering novel insights into the immune response to the YF17D and other flavivirus vaccines and infections. By incorporating these new tools and approaches, the project aims to achieve more refined and effective flavivirus vaccines, expanding beyond yellow fever to address broader public health needs.

Keywords: flavivirus,virus endocytosis,antigen presentation,dendritic cells,antibody response,b cell epitopes,cross reactivity t cell epitopes,t cell quality,immunological memory
Harnessing AI and Data-Intensive Technologies (HARNESS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Ireland,Lithuania,Belgium,Netherlands,Italy,Norway,Austria,United Kingdom
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 3464611.2
EU funding (EUR): 3464611.2
Participants: 18
Project status: SIGNED

The objective of HARNESS is to train a multidisciplinary cohort of 13 PhD students in an international Doctoral Network, specialising in ethics, law, and technology. The network will offer comprehensive training, supervision, and secondments, allowing individuals to become experts in their specific disciplines while gaining practical knowledge across various fields. The program is supported by an excellent team of partners who are world leaders in their respective domains. The ethical and socio-technical impacts of the current and forthcoming AI and data-intensive information systems (e.g. Common European Data Spaces) require careful multidisciplinary consideration and foresight techniques regarding their alignment with EU's values, sovereignty and economic and societal goals. The new European regulations on data and AI should be supported by robust methods and tools to empower citizens and civil society to swiftly comprehend, navigate, and address emerging threats to fundamental rights. HARNESS will analyse the joint impact of new AI and data-intensive technologies and their regulation, considering legal entanglements, new legal compliance tools and the consequences that can be anticipated, from ethical, societal and economic perspectives. AI and data legislation will be formalised and operationalised under the 'Law as Code' paradigm using international standards and semantic web technologies. Specific cases such as AI Foundational models, impact of new regulations on competitiveness and the interplay of self-sovereign identity in Common European Data Spaces will be analysed in detail. HARNESS will utilise and build upon the state of the art in open information systems and knowledge engineering to develop appropriate methodologies, tools, and taxonomies to assist with regulatory compliance, deliberation and agreement on ethical norms. This will involve charting the constellation of possible systems, anticipating new risks and developing effective mitigations.

Keywords: common european data spaces
Education in Graeco-Roman Egypt: An Intercultural Approach (EduGRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1999484.0
EU funding (EUR): 1999484.0
Participants: 1
Project status: SIGNED

EduGRE proposes a radically novel approach to ancient education. Tackling the urgent need to investigate diversity in knowledge transmission in the ancient Mediterranean, the project will comprehensively collate and analyse all school artefacts from Graeco-Roman Egypt, including Egyptian, Greek and Latin material, to set Graeco-Roman education in its specific Egyptian context and explore intercultural osmosis. Challenging the traditional view of Greek education as a tool for perpetuating and disseminating a pure and monolithic form of Greek culture within multicultural communities, this project explores the complex interplay of identities and cultural traditions in educational practices. Through a bottom-up approach that prioritises the concrete experience of individuals who were far removed from the main centres of power and literary production, and who rarely feature in ancient and modern historiographical narratives, EduGRE detects interactions between different languages and cultures, elucidates the role of local agency, and identifies variations in education over time in relation to religious and societal change. EduGRE also introduces a new methodology in editing written artefacts. Its dedicated digital platform will house innovative critical editions combining methodologies of papyrology and New Philology to capture the unique textual iterations encoded in school artefacts. The platform’s uniform editorial methods and tagging system will allow for comprehensive analysis and comparison of educational practices, transcending traditional disciplinary boundaries. The inclusion of images and 3D reconstructions will facilitate analysis of material features. EduGRE will redefine perceptions of ancient education by uncovering cultural diversity and dialogue in its practices. The project’s innovative approach, comprehensive methodology and commitment to inclusivity ensure it will have a lasting impact on cultural studies, both within and beyond antiquity.

Keywords: papyrology,egyptology,ancient education
Hybrid Amplifier Laser for Lidar OperAtions (HALLOA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Italy
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2024-SPACE-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3227060.93
EU funding (EUR): 2735879.34
Participants: 7
Project status: SIGNED

Lidar is a high-performance system for monitoring greenhouse gas emissions from space at a global scale. However, this type of instrument generally includes a complex laser system which has led in the past to significant delays of several European payloads (e.g. ADM-Aeolus, EarthCARE or MERLIN). HALLOA targets the development of a hybrid laser architecture, less complex than current free-space lasers, for greenhouse gas monitoring by Lidar. This laser architecture combines the advantages of fiber-based systems (compact and alignment-free) with those of free-space direct generation systems (high power). This development aims to reach the genuine optical performance for Lidar CO2/H2O monitoring from space and, for independency purpose, to use EU-only components/sub-systems. HALLOA will: 1- Develop new EU industrial capabilities and reach EU independency for two key critical sub-systems of the hybrid laser: the 2,05 µm pulsed fiber amplifier and the high-power laser diode at 793 nm 2- Space qualify to TRL6, the pulsed fiber amplifier at 2.05µm and the high-power laser pump diode at 793 nm 3- Demonstrate experimentally that a complete hybrid laser system, built with EU-only components/sub-systems, can meet the space-mission requirements for Lidar CO2/H2O monitoring. Finally, HALLOA will provide a technical roadmap to establish a European supply chain for the 2µm hybrid-laser system for Lidar application, including a business plan for commercial exploitation of the pulsed fiber amplifier at 2µm and a strategy for space mission insertion. The project involves 6 entities, including 3 non-profit research entities (ONERA, LMD, LZH), 2 industry key-players (KEOPSYS, LPI) and 1 SME (ERDYN). It will pave the way for building a cutting-edge and competitive European supply-chain. The TRL6 demonstration of a hybrid laser system in the eye-safe region for Lidar CO2 measurements will represent a major step forward for EU technological independence in this domain.

Keywords: hybrid laser system,dial lidar,pulsed thulium doped fiber amplifier,holmium free space amplifier,high power laser diode,co2 monitoring,h2o monitoring,sovereign supply chain,eye safe region