Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geotechnical Resilience through Intelligent Design (GRID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Italy,Norway,Germany,Portugal,United Kingdom,China,Ireland,Argentina
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 1295228.57
EU funding (EUR): 1242000.0
Participants: 13
Project status: SIGNED

Our proposed research initiative seeks to propel machine learning into the forefront of geotechnical engineering, with a vision to address critical challenges and revolutionise the field for the betterment of society. The overarching goals of our project align with the need to confront uncertainty, combat climate change through zero carbon emission strategies, address soil parameter heterogeneity, expedite finite element (FE) calculations e.g., for reliability analyses, and enhance design efficiency to reduce material consumption, particularly in the context of concrete. By undertaking this multidimensional approach, our research aims not only to apply machine learning in geotechnical engineering but to fundamentally transform the field, ushering in a new era of efficiency, sustainability and resilience. Through collaboration and innovation, we aspire to make machine learning an integral and indispensable tool for addressing the complex challenges faced by geotechnical practitioners in the 21st century.

Keywords: generative ai geohazards geomechatronics interpretable ai machine learning physics informed neural networks tailing dams tunnelling
Cost-effective prOdUction of ligNin plaTform chemicaLs Extending the biobaSed chemicalS portfolio (COUNTLESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Belgium,France,Switzerland,Germany,Italy,Israel,Estonia,Finland,Türkiye,Netherlands
Call: Cost-effective production routes towards bio-based alternatives to fossil-based chemical building blocks (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 6903903.25
EU funding (EUR): 5400014.0
Participants: 13
Project status: SIGNED

Europe´s ambitious sustainability and climate goals are heavily relying on the transition from fossil-based to bio-based chemical building blocks. Lignin as abundant natural resource has substantial potential to serve as starting material for the production of functionalized aromatic compounds. Only 1-2% of the lignin annual production is used in chemical conversion. Critical challenge to overcome is the heterogeneous and complex nature hampering the full exploitation of isolated lignins. To address this challenge, COUNTLESS will demonstrate the first catalytic hydrogenolysis process operated in continuous mode at industrially relevant scale for the cost-effective and sustainable production of lignin-based platform chemicals. COUNTLESS will demonstrate the applicability and cost-effectiveness of lignin-based platform chemicals in a variety of end-use cases from bulk to specialty applications. This project is formed by key partners covering the whole value chain including feedstock suppliers, technology development experts, well-recognized industry players in the respective application fields, experts in dissemination, communication and exploitation, and experts in integrated sustainability, environmental, and techno-economic assessments. Revenue streams will result from licensing agreements and an increase in turnover and margin for COUNTLESS suppliers and application partners. We anticipate a positive NPV and IRR in 15 years of operation. COUNTLESS contributes directly to the CBE-JU SIRA and KPIs through the increased use of sustainably sourced biomass, reduction of GHG emissions through improvements in the pilot infrastructure (>50% reduction in GHG emissions and 85% using fully renewable supply) and the development of bio-based high-value products substituting current fossil-based compounds.

Keywords: lignin,bioaromatic building blocks,refinery,scale up,continuous processing,polyurethanes,additives,adhesives,sustainable development
Role of astrogliosis in the recurrence of brain tumors after microsurgical resection (GlioSurg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 209686.88
EU funding (EUR): 209686.88
Participants: 2
Project status: CLOSED

Malignant primary and secondary brain tumors represent the deadliest types of human cancer. Glioblastoma is the most common and the most lethal primary brain tumor. Standard of care is based on maximal surgical safe resection, followed by fractionated radiotherapy, with concomitant and adjuvant systemic chemotherapy. Despite optimal treatment, the recurrence rate is higher than 90%. On the other hand, brain metastases (secondary brain tumors from distant organs) remain a substantial contributor to overall cancer mortality, being the main cause of death in up to 50% of affected patients. Research on the resistance to chemo and radiotherapy has been widely performed; however, studies on the impact of surgery on the cellular biological phenotype have been curiously neglected even if the standard of care requires that all patients receive surgical resection if possible. The contribution of the neuroinflammation to cancer progression is extensively studied. However its role after surgical injury remains to be elucidated. Therefore, we aim to mechanistically decipher the role of reactive astrocytes (key regulators of neuroinflammation) on the post-surgery recurrence of primary and secondary brain tumors. We will use intravital microscopy, digital pathology, genetic and pharmacological selective targeting of reactive astrocytes and ultimately, we will evaluate novel therapeutic approaches to improve clinical benefit.

Keywords: microsurgery astrocyte glioblastoma breast cancer brain metastasis intravital microscopy
Systems Methods Context (SyMeCo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1528320.0
EU funding (EUR): 1528320.0
Participants: 11
Project status: SIGNED

SyMeCo (Systems, Methods, Context) proposes a transformative agenda, one that is cognisant of the changing landscape of software development, while seeking to shape it. The key research strands explore what we build (Systems), how we build these systems (Methods), for the world we want (Context). The 60-month research training programme will fund 16 postdoctoral fellowships at Lero, and will incorporate international mobility, intersectoral exposure, and interdisciplinarity. Lero is Ireland’s Research Centre for Software, headquartered at the University of Limerick (UL, Beneficiary), with partners in other Irish universities and institutes of technology. The Implementing Partners will be University College Cork, University College Dublin, Dublin City University, National University of Galway and Trinity College Dublin. The ten Associated Partners are drawn from Lero’s extensive Industry network and comprise a mixture of multi-national corporations and SMEs. The programme aims to attract researchers from the fields of computer science, software engineering, information systems, human-computer interaction and business management. During their 2-year fellowship, fellows will receive discipline-specific skills training to assist career development and will be provided with a comprehensive set of courses to improve their transferrable skills to diversify their employment options. Fellows will also avail of a 4-day Summer School incorporating the themes of Systems, Methods, Context with one day dedicated to Industry & Entrepreneurship. Trained fellows will be attractive to industry, the public sector or academia. The SyMeCo research training programme will produce the next generation of European leaders in software development that will have the skills to help in Shaping Europe’s Digital Future and contribute to the newly launched European Declaration on Digital Rights and Principles. This proposal seeks €1.52 million EC funding to match Lero co-funding of €1.38 million.

Keywords: software engineering,information systems,human computer interaction,
Detecting epigenetic biomarkers in the blood for non-invasive precision oncology (EpiDetect)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The detection of circulating tumor DNA allows to non-invasively retrieve tumor molecular profiles and follow disease evolution. These approaches promise optimal and individualized management of patients with cancer. However, despite remarkable progress, several technological obstacles still limit liquid biopsy widespread application. Indeed, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge. Samples collected at early stages or during treatment may contain less than one mutant copy per milliliter of plasma, which is below the detection limit of current technologies. Moreover, detectable recurrent mutations do not cover all patients. It is therefore necessary to develop new, more sensitive, but also more informative tools. My goal is to develop new methods detecting epigenetic markers from peripheral blood for establishing more efficient non-invasive diagnostic tests and disease monitoring. Targeting the cancer epigenome, which contains a myriad of somatic alterations that do not modify the DNA sequence and cover cases without detectable mutations, will achieve increased sensitivity. These markers could become decisive in detecting residual disease and early stages of multiple forms of cancer. I will develop approaches to: 1) Analyze circulating DNA methylation profiles at unique and repeated sequences; 2) Identify circulating DNA cells of origin using nucleosome footprint; 3) Analyze transcripts associated with circulating extracellular vesicles. Ultimately, a single test integrating DNA methylation profiles, fragmentation patterns and EV-associated transcripts, from the same plasma sample, will be developed. This project has both fundamental and biomedical implications: it will generate in-depth knowledge of the biology of circulating non-genetic tumor biomarkers and lead to the development of more efficient non-invasive diagnostic tests adapted to all types of cancers, based on the universality of these factors.

Keywords: circulating tumor dna,biomarkers,epigenomics,precision medicine,dna methylation,nucleosomal foot printing,extracellular vesicles,non coding rnas
Shaping symbiosis in bio-based industrial ecosystems based on circular by-design supply chains (SYMBIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Italy,Slovenia,Spain,Austria,Belgium,United Kingdom,Croatia
Call: Symbiosis in the bio-based industrial ecosystems (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1493332.14
EU funding (EUR): 1301318.75
Participants: 9
Project status: SIGNED

The SYMBIO project provides European regional communities with tools and methodological approaches to building bio-based business models based on circularity by-design and industrial symbiosis. Thanks to tools for integrating big data and artificial intelligence, SYMBIO shapes 10 symbiotic business models with high-profitability sustainability replicable at the EU level to increase bio-based products on the market and provides a system to modelling, measure and monitor symbiosis and its social, economic and environmental impacts. SYMBIO methodology will be designed, tested and validated in 12 EU pilot regions (Lombardy, Piedmont, Veneto, Friuli-Venezia Giulia, Emilia-Romagna, Carinthia, Slovenia, Croatia, Andalusia, Bruxelles Capital, Wallonia, Flanders) that have been selected based on the estimation of their bio-based resources defined by raw material availability, socio-economic indicators, intangible networks and infrastructures and potential for development of CBE close-to-market supply chains and current trends. Involving all supply chain actors in a quadruplex approach will help unlock and stimulate local development potential by promoting sustainable, innovative, tangible and participatory pathways to the green transition through an inclusive bottom-up CBE nexus.

Keywords: industrial symbiosis,biobased industries,value chains,artificial intelligence
Bridging the sex gap in traumatic brain injury biomechanics (brainsex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1499914.0
EU funding (EUR): 1499914.0
Participants: 1
Project status: SIGNED

Traumatic brain injury (TBI) is a multi-anatomical-scale mechanical injury affecting 30 million women globally each year. brainsex will focus on the sex specific biomechanics of TBI in the elderly population motivated by the highest reported incidence of TBI in people over 75 years old. Furthermore, in the elderly population women account for more TBIs than men. However, women remain underrepresented in TBI research. Finite element brain models (FEBMs) have played a major role in improving our understanding of TBI. However, current FEBMs have been developed using male-only data and cannot accurately model female TBI due to the distinct sex specific neuroanatomies. I will embark on frontier research to test the hypothesis that TBI biomechanics are sex specific due to the multiscale sex specific neuroanatomy, causing damage to brain tissue, cerebral vasculature, and neurons under lower impact forces in women compared to men. To realize this ambitious goal, my team and I will develop ground-breaking sex specific FEBMs incorporating the multiscale sex specific neuroanatomy and constitutive damage properties of brain tissue and cerebral vasculature providing more accurate predictions of TBI from high energy head impacts. We will develop novel experimental technologies to characterise the constitutive damage properties of brain and cerebrovascular tissue (Aim 1), and neurons (Aim 2) under conditions required to model brain deformation during TBI. This data will be used to develop the first ever microstructure-informed constitutive damage model for brain tissue (Aim 2). This model combined with the FEBMs will revolutionise TBI biomechanics (Aim 3). brainsex will open new research horizons for biomechanics research focussing on the important role sex plays in tissue biomechanics. brainsex will deliver a breakthrough in our understanding of TBI biomechanics by delineating the sex dependent mechanical behaviour of brain tissue and cerebral vasculature during head impacts.

Keywords: biomechanics traumatic brain injury constitutive model experimental biomechanics atomic force microscopy
Fostering a common approach for the regulation of Artificial Intelligence in procedural criminal systems (FUTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Artificial intelligence is rapidly permeating diverse domains. In the criminal procedural field, AI is enhancing the efficiency of law enforcement authorities and criminal justice systems in both preventing and prosecuting crimes, through the streamlining of tasks like data analysis, evidence assessment, and crime prediction. Despite this accelerating trend, a conspicuous gap persists due to the lack of a clear and comprehensive legal framework at both national and supranational levels. An additional factor hindering a responsible and beneficial implementation of AI in the criminal procedural sector is that some technical characteristics of the AI prototypes developed so far (e.g. opacity) interfere with some criminal procedural principles and standards. The lack of dialogue between legal scholarship and scientific community prevents the identification of suitable technical solutions. Given this scenario, managing the legal and ethical implications of AI in the criminal justice system proves to be a prohibitive challenge. The aim of FUTURE is twofold: to support national legislators across the EU in the regulation of artificial intelligence in criminal procedure, while fostering a harmonized approach to the subject; to bridge the gap between the technical and the legal community, ensuring the compliance of AI systems implemented in the criminal procedural field with its principles and safeguards. To achieve these objectives, FUTURE will firstly employ the legal comparison method in a groundbreaking manner: it will be applied on a comprehensive legal and empirical data set, covering all EU Member States’ jurisdictions. Secondly, it will bridge the expertise of legal and computer science professionals, giving them the first tangible chance to investigate the technical issues obstructing the use of AI in criminal proceedings and to assess the feasibility of technical solutions.

Keywords: artificial intelligence criminal procedural law and policy law and technology harmonisation in eu comparative method procedural and fundamental rights ai technical aspects and criminal procedure
Showcasing Advanced Hydrogen Valley in Western France (AdvancedH2Valley)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Spain,Italy
Call: Small-scale Hydrogen Valley (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2027-02-28
Duration (months): 38.0
Total project cost (EUR): 64350099.25
EU funding (EUR): 8998617.08
Participants: 22
Project status: SIGNED

AdvancedH2Valley aims to accelerate the deployment of renewable hydrogen in the Loire Valley in France by 2025 and prepare the future large-scale hydrogen economy in the European Atlantic Coastline. The project is built on successful first achievements of H2Ouest and VHyGO (Vallée Hydrogène Grand Ouest), two hydrogen ecosystems initiated in 2019. AdvancedH2Valley is taking a big step forward in accelerating renewable hydrogen deployment in Western France as it will initiate: - 11.5MW of new production capacities along with innovation to optimize operation process representing >1600t 100% certified renewable H2/year by 2028, in line with the Delegated Act of the EU’s Renewable Energy Directive; - 2 new HRS with distribution capacity of up to 1,3t/day on RTE-T network; - 1st hydrogen trucks fleet deployment in France, as well as innovating off-road port logistics vehicles and river ferry; - 1st renewable hydrogen supply chain adapted to industrial customers specific requirements, in order to quickly decarbonize even the “small” industrial hydrogen consumptions; - Innovations to enhance valley operation (multi-sites coordination, optimised truck filling). AdvancedH2Valley ambitions to be both a lighthouse and an innovation lab for hydrogen valleys. The consortium will strengthen collaborations and synergies between neighboring regions and especially pioneering peripherical maritime regions of the Atlantic Arc. The partners will actively share to them the knowledge generated on the project to foster the scalability and replicability of the AdvancedH2Valley model, and to pave the way for the future large-scale hydrogen economy in Europe. The main expected impacts of the project are the direct decarbonization of transport and industrial activities using renewable hydrogen: 14,6t of CO2 will be avoided during the 2-year operation, and 2,8Mt per year by 2036.

Keywords: hydrogen,h2 valley,hydrogen valley,renewable hydrogen,renewable energy,decarbonation