Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Establishment and maintenance of gene expression by heterochromatin factors (METACHROM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-11-30
Duration (months): 78.0
Total project cost (EUR): 1999025.0
EU funding (EUR): 1999025.0
Participants: 1
Project status: SIGNED

Metastable epialleles are alleles that are variably expressed in genetically identical individuals. These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment. The epiallele’s state can subsequently be maintained throughout development and adult life. Studying the mechanisms underlying establishment and maintenance of chromatin states is critical to understanding how the environment can shape the epigenome and how it can impact on diseases and aging. Most mouse metastable epialleles result from a nearby insertion of an endogenous retrovirus, which induces position effect variegation. In mouse embryonic stem cells, these elements are silenced by the histone methyl-transferase SETDB1 which imparts heterochromatin features by tri-methylating histone H3 on lysine 9. In the same cells, telomeric H3K9me3 is also installed by SETDB1 but surprisingly, we found that H3K9me3 correlates with enhanced transcriptional activity at telomeres. I hypothesize here that metastable chromatin states are controlled by H3K9me3 and associated factors, which are targeted to defined positions that can either instruct silencing, or support active expression. To understand how metastable chromatin states are regulated, we will first use a locus-specific chromatin proteomics approach to identify H3K9me3-dependent factors in the contexts of transcription or repression. Next, both pathways will be reconstituted by tethering those factors at specific positions on model genes, and maintenance of these states will be analyzed. Finally, to obtain a comprehensive picture of the metastable states establishment and maintenance, we will map heterochromatin factors genome-wide, in response to distinct stimuli in mESCs. This proposal will deepen our understanding of the mechanisms by which mammals use gene regulation to adapt to environmental conditions.

Keywords: heterochromatin,epigenetic memory,stress
Development of a compact, user-friendly and cost effective source for the generation of powerful and broad ultrashort pulses in the deep-UV (DUVlight)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 140625.0
EU funding (EUR): 140625.0
Participants: 1
Project status: CLOSED

Here we present an original design of a compact and portable set-up able to generate very broadband (70-100 nm at 300 nm) and powerful (>1uJ/pulse) ultrashort deep-UV pulses. Compared with other schemes, it guarantees an aberration-free propagation, an easy installation and minimal dispersion. The present project aims to bring the current prototype to the level of a commercial device. The conceived design will allow to manufacture a compact, portable and cost effective device, which will be user-friendly and with almost no required maintenance. There is no such a source commercially available and the schemes proposed in scientific literature require an advanced level of competence in optics and laser physics, are not cost effective and unsuitable for industrial applications. There is thus a need of sources for ultrafast broadband radiation in the deep-UV to advance and enable new ultrafast science and extend into this spectral range the technological application of ultrafast laser sources. The implementation of the proposed device will definitively fill this gap.

Keywords: ultrafast,achromatic doubling,second harmonic generation,deep uv,femtosecond,non collinear optical amplification,non linear optics
Thermal and ELectronic Transport in Inorganic-Organic ThermoElectric Superlattices (TELIOTES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The global older population will double its current size by 2050, reaching 2.1 billion. As a result, further medical attention for this increasing population will require a new generation of more reliable and energy-efficient medical devices. Devices such as therapeutic wraps and blankets can benefit from materials that can generate cold from electricity without moving parts, minimising the discomfort on the patient. These materials are called thermoelectrics because they convert electricity into cold or heat, or vice versa. However, their use as therapeutic tools is limited because they are currently made with brittle and often toxic compounds. Luckily, this limitation can be overcome by replacing these compounds by flexible materials such as polymers. Therefore, the goal of this action is to investigate how efficient is the generation of cold with these new polymer-based hybrid materials under different conditions. As these hybrid materials will be bent or even twisted during their use, this action goes beyond the typical studies, where their efficiency is studied in ideal conditions with no deformation, to answer the following question: how does this efficiency vary when the material is strained? This action is not only aimed at policymakers and medical doctors to show them the benefits of fundamental research on thermoelectric materials, but also at the scientific community and patent engineers to provide cutting-edge results to guide them in building the next generation of medical devices for the senior members of our communities.

Keywords: quantum mechanics,first principles simulations,thermoelectric materials
Value-of-Information Driven Communication for Connected and Automated Transportation (VoiiComm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-26
End date: 2022-10-25
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

By fusing the sensing information provided by the automated vehicles (AVs), an accurate and real-time representation of the highly dynamic traffic environment can be formed and disseminated to all traffic participants, to enable a variety of safety and efficiency improving applications and push the transition towards connected and automated transportation. A powerful wireless network plays a key role in this vision. As the number of AVs increases, however, the huge data volume will easily exceed the capacity of the wireless network. Owing to the application-oriented nature of vehicular communication, a paradigm shift towards the value-of-information (VoI) driven design is crucial to avoid wasting network resources and degrading traffic safety and efficiency. Nevertheless, no simple mathematical model and existing theory can be applied to assess VoI exactly. The main goal of the VoiiComm project is to establish a theoretical framework and practical methods for evaluating and modeling VoI statistically, by exploiting the intrinsic relationships between traffic flow, density, and speed, to enable the systematic design of efficient communication protocols. The specific research objectives are (1) Design metrics that capture the space-time statistical properties of VoI; (2) Analytical and empirical modeling of spatio-temporal VoI metrics; (3) Strategy development for efficient sampling and transmission scheduling. By accomplishing these objectives, data congestion and resource waste can be avoided, and the potential benefits of AVs can be maximized as their number gets large. VoiiComm will initiate a fresh new interdisciplinary research area and advance the transformation to sustainable and automated transportation and society. In parallel, it will allow the ER to achieve several knowledge transfer and training objectives, increase prominence in her research field, and enhance her career prospects in academia.

Keywords: vehicular communication,connected and automated vehicles,cooperative sensing,value of information
small Scale interlocking mechanisms for Strong and Tough mEtamatEriaL (SSTEEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1499711.0
EU funding (EUR): 1499711.0
Participants: 1
Project status: SIGNED

Brittleness limits the design and lifetime of some polymeric, metallic, and almost all ceramic materials in both structural and functional engineering applications, from the design of plane engine turbine blades to the newest solid-state electrolyte in batteries. This brittleness is intrinsically present in material composition that cannot plastically deform and make them sensitive to any defect introduced during their fabrication or usage. The goal of this project is to produce small Scale interlocking mechanism for Strong and Tough mEtamatEriaL (SSTEEL) that will provide a material independent solution to brittleness. Interlocking mechanisms provide in theory one of the most efficient way to increase toughness by creating crack blocking compressive stresses in response to tensile stresses. Because a brittle material strength is inversely linked to its size, my team and I first objective will be to develop a new process to form interlocking mechanism based on micron-sized elements using a combination of light-based additive manufacturing, shrinking ink design to access sub-printer resolution, and fragmentation. The second objective will be to implement this mechanism at an even smaller scale using rational material selection, solid state chemistry, and colloidal processing to fabricate an interfacial binder for the elements. The fracture process of SSTEEL sample will span several length scales and a specific task will be to use a combination of image correlation and modelling to fully characterise the existing damaging mechanism and inform the improvement of future designs. These new structures and concepts developed by my group will promote the development of tough structure for today’s and future structural and functional engineering applications by changing any brittle material to become strong, stiff, deformable, and reliable materials.

Keywords: mechanical properties,colloidal processing,additive manufacturing,toughness
From Postdoc to PI: Future leaders of ERA (PD2PI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 2758500.0
EU funding (EUR): 1379250.0
Participants: 1
Project status: SIGNED

From Postdoc to PI: Future leaders of ERA (PD2PI) is a novel postdoctoral programme of the Institute of Physical Chemistry of the Polish Academy of Sciences (IPC), designed to foster new generation of scientists (Experienced Researchers) to become independent leaders/managers capable of working in business and/or academia. PD2PI programme will contribute to the creation of researchers for a commercial labour market. The project will be carried out by the leading research entity in Poland with highest excellence category in Poland (A+). PD2PI offers research training programme, based on 3-i approach (i.e. intersectoral/-national/-disciplinary), in the field of broadly understood chemistry with its links to medicine/biology and physics (3-36 months). This is guaranteed by adequate training (transferable skills training included, and lecturers from both sectors of the economy) & research programme but also participation of excellent (11 research and 6 business) units from Poland and abroad. Moreover, inclusion of a tenure track into the programme creates a unique offer for postdocs.The PD2PI fellows will be free to choose research area from IPC offer and submit own interdisciplinary research proposal, which will be evaluated with participation of international experts in a transparent competition (ca. 3 calls). Each successfully selected project will be carried out within the framework of international cooperation. Co-/mentors are well recognized in the international community (incl. ERA), with strong record in mentoring and advising. The PD2PI programme will take advantage of the best practices supporting researchers' careers. IPC is committed to the values underlying the Charter&Code, which are basically implemented under IPC. PD2PI fellows will be supported throughout the whole stay (assistance in stay legalization, flat rental, relocation/family allowance, private&public medicale care). This unique opportunity will give a good perspective for future career.

Keywords: chemistry,combining chemistry with physics,biology,medicine,tenure track,leadership training
Better Languages for Statistics: foundations for non-parametric probabilistic programming (BLaSt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1931178.0
EU funding (EUR): 1931178.0
Participants: 1
Project status: SIGNED

Probabilistic programming is a powerful method for Bayesian statistical modelling, particularly where the sample space is complex or unbounded (non-parametric). This is because the statistical model can be described clearly in a way that is precise but separate from inference algorithms. It accommodates complex models in such a way that outcomes are still explainable. The objective of the proposed research is to develop a semantic foundation for probabilistic programming that properly explains the non-parametric aspects, particularly the symmetries that arise there. There are three ultimate goals: * to propose new probabilistic programming languages: better languages for statistics; * to devise new general inference methods for probabilistic programs; * to build new foundations for probability. The method is to build on advances on exploiting symmetries in traditional programming lan- guage semantics, by combining this with recent successes in formal semantics and verification for probabilistic programming.

Keywords: probabilistic programming,semantics of programming languages,monads,category theory,abstract types
Accurate characterization of charge-transfer excited states (AccuCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-04
End date: 2019-01-03
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

Charge transfer (CT) processes play an important role in photosensitizers and photocatalytic reactions that have found great potential in solar energy conversion and enviromental remediation. Density Functional Theory (DFT) is the archetype method to perform all kind of computational simulations due to its favorable combination of efficiency and accuracy. CT processes are among the most difficult challenges for DFT and currently a reliable, efficient and size-extensive method is missing. The goal of this project is developing a new family of long-range corrected density functionals for the quantitative description of CT excited states that also achieves better global performance of other properties. The current approach employs a physically sound strategy based on using density-related properties to construct attenuating functions, avoiding the undesirable biases produced by parameter fitting. By correcting CT description, the new functionals hold the promise to extend its applicability to a wider range of properties and pave the way towards the development of all-purpose functionals.
Energy efficient greenhouse dehumidifier for warm climate operating at wide temperature ranges (4-40° C) and free of fluorinated gases (Drygair20)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We are DryGair Energies an Israel-based agritech SME established in 2010. Israeli climate has a severe dry season, so every water drop counts. This is how the idea of developing a climate solution saving energy and creating reusable water initiated the prototype of DryGair20, a revolutionary energy saving dehumidifying system that works efficiently throughout the whole growing season in both cold and warm climates thanks to a wider temperature range of operation (4-40°C instead of current 10-26°C). To this clear competitive advantage (current dehumidifiers are only efficient in cold climates), it is added its ability to work with non-fluorinated refrigerants, to be prohibited in Europe by 2020. This converts DryGair20 the unique real option in the short term for greenhouse growers aiming at complying with European 2020 regulations by upgrading/installing the new generation of effective dehumidifiers to save current high energy and fungicide costs. DryGair20 will reduce up to 20% overall energy costs of greenhouse exploitations, by means of a 40-60% decrease in heating (~40,000-60,000 €/year/ha). Its 500% higher effectivity in humidity removal (4 L water/Kwh instead of 0.7-1.5 L/Kwh of venting/heating systems), will allow 80% savings in fungal pesticides, while crops will become much less exposed to pathogens since the lack of need to open greenhouse windows for venting, and low humidity. 2-8°C higher temperature and uniform air regime for optimal plant growth inside the greenhouse will also contribute to an overall outcome of 20-25% rise of crop productivity and quality with much less energy and pesticide costs, and lower environmental impact in terms of CO2 emissions and pollution. Potential market size for DryGair20 in the targeted European countries by 2021 is €2.3 billion. With a final price of €22,000, DryGair20 forecasted turnover by 2021 amounts to €16.5 million with a net profit of € 2.5 million (payback of 2 years). Workforce will increase in 20 people.

Keywords: greenhouse dehumidifier,humidity control,moisture control,temperature range,fluorinated gases,r507,crop quality
SUstainabLe Tunnel Agriculture with light cascade techNology (SULTAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: France
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cascade, a spin-off of LPRL laboratory, is a French SME located in Clamart founded by Mr Frederic PEILLERON in 2012. For more than 20 years, the LPRL, a French private laboratory, has been working on “light cascade" effects that create a shift of the solar spectrum which leads to a doping of the natural process of photosynthesis in greenhouses. With this unique and innovative know how, Cascade decided to develop an environmental solution to improve the agronomic yield of crops in greenhouses. This solution increases food production of protected crops of fruit and vegetables using sustainable and efficient processing. It reduces cost of food production as it allows more efficient use of farmland. Light cascade technology brings a perfect answer to the requirement of a green-efficient, cost-saving solution to increase crop yield and reduce production cycles. This is a growing a European and a global market creating huge business opportunities. Most all European countries and a large part of the world are in need of environmental and sustainable solutions to improve crop yields. This interest fuels development of world greenhouse market, a long term growing market with huge business opportunities. Cascade’s long-term objective is to become the world specialist in sunlight spectrum control solutions. Our objective is to become a new standard in the market. Cascade’s solution is a revolutionary and sustainable way to improve agronomic crop yields in greenhouses and thus food production. It is technologically ready for industrialization. Now, Cascade needs to perform a feasibility study to define and validate the best marketing strategy to adopt during the first SME instrument in order to start industrialization and sales of the solution during SME instrument phase 2 and 3.

Keywords: light cascade effects,shift solar spectrum,increase food production,efficient plant photosynthesis,environmental solution,natural process,protected crops,greenhouses,improved agronomic yield