Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EUROpean network for transnational collaborative RTD projects in the field of NANOMEDicine (EURONANOMED II)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Coordination and support actions
Partnership: EURONANOMED II (ERA-NET)
Countries involved: France,Belgium,Belgium,Germany,Germany,Iceland,Israel,Italy,Latvia,Lithuania,Norway,Poland,Portugal,Romania,Spain,Sweden,Switzerland
Call:  (FP7-ERANET-2012-RTD, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 1765720.91
EU funding (EUR): 1499990.0
Participants: 23
Project status: CLOSED

Nanomedicine, the application of nanotechnology to health, is a fast-growing field with a large potential for improving diagnostics and therapeutic solutions in many diseases. The EuroNanoMed II (ENM II) consortium, with 20 partners from 17 countries and regions, aims to foster the competitiveness of European nanomedicine actors through the support of translational research projects enhancing transnational and multidisciplinary collaborations between academia, clinical/public health communities and industry. ENM II will be a follow-up of the ERA-NET EuroNanoMed I (ENM I), which launched three joint transnational calls for proposals in three years. The increasing number of submitted proposals in the successive ENM I joint calls and their quality show the need amongst the nanomedicine scientific community for such a targeted initiative. ENM II will be built on the basis of the ENM I accomplishments, and will continue to support transnational innovative RTD projects in nanomedicine through the launch of yearly joint calls for proposals. In addition, ENM II aims to extend the cooperation among its partners through the development of other activities: (i) foster the participation of young European researchers to ENM II activities; ii) develop a strategic agenda for ENM II in close cooperation to the ETP Nanomedicine; iii) create more interactions within the European nanomedicine community and improve communication on nanomedicine to the public; iv) frame and address regulatory, safety and ethical issues associated with nanomedicine; v) monitor the results of the ENM I & ENM II funded research projects and the activities of the ENM II network; and, vi) develop a long-term cooperation framework for European nanomedicine research. Therefore, through joint funding of translational nanomedicine projects and its other activities, ENM II will contribute to enhance coordination of research and resources in this field, thereby shaping the European Research Area in nanomedicine.

Keywords: nanomedicine,translational research,nanotechnologies,targeted delivery systems,diagnostics,regenerative medicine
ERA-NET on Solar Electricity for the Implementation of the Solar Europe Industry Initiative (SOLAR-ERA.NET)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Horizontal programme actions
Action type: Coordination and support actions
Partnership: SOLAR-ERA.NET (ERA-NET)
Countries involved: Switzerland,Germany,Finland,France,Spain,Belgium,Belgium,Poland,Türkiye,Netherlands,Greece,Cyprus,Italy,Italy,Austria,Sweden,United Kingdom
Call:  (FP7-ERANET-2012-RTD, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 2284101.34
EU funding (EUR): 1999987.77
Participants: 20
Project status: CLOSED

The goal of SOLAR-ERA.NET is to undertake joint strategic planning, programming and activities for RTD and innovation in the area of solar electricity generation, i.e. photovoltaics (PV) and concentrating solar power (CSP). Joint activities, namely joint calls, are defined for key topics and priorities in accordance with the Solar Europe Industrial Initiative (SEII) based on the Strategic Energy Technology (SET) Plan and its related Implementation Plans for PV and CSP. The network's activities will primarily involve the launching of joint calls for RTD proposals by national and regional RTD and innovation programmes. In order to define and support best joint activities, strategic information exchange and use of implementation tools will be carried out among the network participants and associates from key stakeholder groups. As the largest European network ever - with 19 partners from 18 countries and regions - in the solar power field, SOLAR-ERA.NET will involve more than 20 RTD and innovation programmes dealing with PV and CSP. This high level of involvement of most relevant stakeholders will provide excellent outreach and coordination needed for an efficient and coherent approach in the highly diverse and versatile RTD landscape. The EC funding (for the ERA-NET project) shall be multiplied by a factor of 50 in the form of joint calls. These joint calls for RTD and innovation topics in PV and CSP shall result in a total funding volume by the participating programmes of at least 50 MEUR. Assuming an average leverage factor of associated funding by industry and research of 2,5, this shall lead to the mobilisation of at least 125 MEUR in joint projects. SOLAR-ERA.NET will thus contribute to reach the objectives of the SEII, namely boosting the development of the PV and CSP sector beyond “business-as-usual”, and of the ERA-NET, namely enhancing cooperation between the national/regional programming stakeholders at European level.

Keywords: photovoltaics,concentrating solar power,solar europe industry initiative,implementation plans,set-plan
IMPROVING THE SAFETY AND MOBILITY OF VULNERABLE ROAD USERS THROUGH ITS APPLICATIONS (VRUITS)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Finland,Netherlands,Sweden,Spain,Belgium,United Kingdom,Italy,Netherlands,Netherlands,Austria,Spain,Netherlands
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-04-01
End date: 2016-03-31
Duration (months): 36.0
Total project cost (EUR): 4143667.0
EU funding (EUR): 2930947.0
Participants: 12
Project status: CLOSED

In the past, Intelligent Transport Systems (ITS) success has been achieved primarily though equipment of the vehicle and infrastructure. The focus of these ITS has been on clean, safe and efficient mobility for vehicles. The Vulnerable Road User (VRU) has reaped fewer benefits of the ITS developments. While some projects have considered VRUs from a safety viewpoint, they often aimed to avoid or mitigate accidents with VRUs by equipping the vehicle and infrastructure. In the vehicle – infrastructure – human approach of ITS research, VRUs and their needs are not an active part of the “human” element in the ITS approach. What is needed? The VRU must become an active, integrated element in the ITS, addressing safety, mobility and travel comfort needs of VRUs. The VRUITS project will develop an architecture for integrating the VRUs into the cooperative ITS. VRUITS will recommend ITS that meet the needs of VRUs. Ex-ante and ex-post assessments will form input to these recommendations. Assessment methodologies will be modified to account for specific user behaviour of VRUs. Specifications for ITS applications will be developed, culled from focus group assessments per VRU group. VRUITS will recommend best practices to address HMI development for VRUs. Field trials in the Netherlands and Spain for a select number of applications will take place. VRUITS will recommend which actions for the EC and for other stakeholders are necessary to deploy the systems which have positive effects, and mitigate possible negative effects. VRUITS will fulfill the following objectives: 1. Assess societal impacts of selected ITS, and provide recommendations for policy and industry regarding ITS in order to improve the safety and mobility of VRUs; 2. Provide evidence-based recommended practices on how VRU can be integrated in Intelligent Transport Systems and on how HMI designs can be adapted to meet the needs of VRUs, and test these recommendations in field trials.

Keywords: its,impact assessment,vru safety,vru comfort & mobility,recommendations,cooperative traffic systems,hmi
A European Maritime e-Compliance Cooperation Model (E-COMPLIANCE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: United Kingdom,Norway,Cyprus,United Kingdom,Netherlands,France,Spain,Latvia,Spain,France
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-06-01
End date: 2016-05-31
Duration (months): 36.0
Total project cost (EUR): 4424498.0
EU funding (EUR): 2805012.0
Participants: 11
Project status: CLOSED

e-Compliance will build upon strengths created across numerous EU projects in order to facilitate tighter integration and co-operation in the fragmented field of regulatory compliance in the maritime domain. Regulations are created by numerous different bodies, with little co-operation between them. As such, there is a significant lack of cohesion between the vast array of regulations and the possibility of conflicting regulations is very real. By creating a model for managing regulations digitally and creating services for all the different stakeholders, e-Compliance can harmonize these regulations and allow for co-operation between the different stakeholder groups. Not only will this improve the quality of regulations, but it will also reduce the burden for those having to enforce the regulations as well as those who must comply, resulting in a regulatory regime that is more effectively implemented. e-Compliance will also develop capabilities to ensure that all stakeholders are aware of the current active regulations and allow preparation for regulations that will take effect in the future.

Keywords: compliance,regulations,imo,e-compliance,e-maritime,ontologies,semantic,harmony,maritime,classification,pcs,port,port community system,nsw,national single windows
Towards an evolutionary ecology of spermatogenesis (SPERM EVOLUTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2015-03-31
Duration (months): 31.0
Total project cost (EUR): 64583.33
EU funding (EUR): 64583.33
Participants: 1
Project status: CLOSED

The essentials of sperm function differ little from one species to another, and yet there is tremendous diversity among species in the type and number of sperm a male produces. My research programme aims to understand how these traits, which are fundamental to male fertility, evolve. Specifically, I aim to identify selective forces acting on sperm, spermatogenesis and the testis, and adopt a multidisciplinary approach to test the working hypothesis that post-copulatory sexual selection has been a major force during sperm and testis evolution. Such a research programme is needed, because evolutionary biologists have traditionally treated the testis as a “black box” (ignoring the details of its function) whereas more clinically-orientated research has usually not considered how evolutionary history shapes the complex machinery of spermatogenesis. The time is ripe for a more integrative programme. In this project, I will build on recent progress to develop Macrostomum flatworms as a model system for studying the evolutionary biology of sperm, spermatogenesis and the testis. By in-depth studies of two closely related flatworm species, and comparative studies incorporating additional species, I will focus on testing how two radically different fertilization mechanisms affect the evolution of male reproductive function. The project will provide crucial information on the genetic architecture of sperm traits; on plasticity in sperm traits; and on how post-copulatory sexual selection shapes male reproductive phenotypes beyond gross testis size. The results of the project will begin to build a more complete “evolutionary ecology of spermatogenesis”, with wide implications for our understanding of the male gamete and its production by the testis; thus they will be applicable both to the immediate field of evolutionary biology, and to related areas of biomedical and clinical research.

Keywords: evolution,reproduction,spermatogenesis,v309 systems evolution,l207 quantitative genetics,v302 biodiversity - comparative biology,v301 animal behaviour,l201 genomics,l202 transcriptomics
Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications (PLATFORM2NANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Chemically synthesized nanomaterials (NMts) are being considered as the active elements in many applications, including, photonics, catalysis, energy, medical diagnosis and treatments. In order to achieve the promise of these applications, it will be critical to have an efficient, reproducible synthesis technique to produce the NMts. Currently, nanoparticles are synthesized in a batch mode in small volumes, which is suffering from irreproducibility and lack of NMts quality from batch to batch. Furthermore there are challenges in scaling batch procedures up to quantities needed for application development. Consequently, a new technological approach is required to assure nanotechnology feasibility. This project takes as a goal the development of multi-functional platforms based on microfluidics (MF) to address the wet-chemistry weaknesses and restrictions of small-scale batch reactors. Basically, MF allow an exquisite control on synthesis variables. The superior reaction control in a microliter or even nanoliter volume, enable to nanoengineer NMts in a continuous production process, addressing some issues such as scaling up and reproducibility. Additionally, MF promote some valuable advantages, including enhancement of mass and heat transfer, feedback control of temperature and feed streams, safer operational environment and potential for sensor integration. A variety of MF approaches will be developed to fine tune the NMts: sequential addition, slug flow, microwave and ultrasound irradiation. Since the applicant is a member of the highly-interdisciplinary Aragon Institute of Nanoscience, several collaborations with researchers from other areas have already been established. This enables the NMts obtained from this emerging technology to be employed in applications related not only to catalysis, which is the applicant´s main field of activity, but also in other areas such as nanocomposites and nanomedicine, where nanoparticles play a key role.

Keywords: microfluidics,microreactors,wet-chemistry,nanomaterials,nanotechnology
Identification and validation of cerebral KCa3.1/KCa2.3 potassium channels a drug tragets for the prevention and treatment of cerebral ischemia associated with diabetes and Alzheimers disease (BRAINIK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The objectives of the project are to identify and evaluate potassium channels of the KCa3.1/KCa2.X type as novel drug targets for the prevention and treatment of cerebrovascular ischemia and neuroprotection in metabolic disease and neurodegenerative disorders associated with vascular pathologies, as a new pathophysiological concept and treatment strategy. To reach these aims, the proponent employs genetic models of ion channel deficiency and experimental models of human disease for pharmacological interventions with highly selective small molecule modulators and performs target identification studies on human material. The project will be conducted within the research frame of the Aragonese Institute of Health Sciences and in collaboration with clinical departments of the University Hospital Miguel Servet in Zaragoza, Spain, and the University Hospital Odense, Denmark, and with neuroscientists and pharmacologists at the University of Southern Denmark and the University of California, Davis, United States, for optimal scientific synergy and use of resources. The 1st and 2nd work packages consist of electrophysiological, molecular biological, and imaging studies using genetic and pharmacological tools for “target identification” in cerebrovasculature from murine and human diabetes mellitus type 2 (DM-2), Alzheimer disease (AD), and Morbus Fabry. The 3nd of work package consists of intervention trials and the testing the efficacy of recently developed small molecule modulators in mice models of DM-2 and AD for “target validation”. The 4th work package consists of epidemiological studies in which we define the genetic variability and polymorphisms in KCa3.1/KCa2.3 genes in Aragon Workers Health Study (AWHS)-cohort and evaluate their potential predictive value for disease. Our conceptually new approach and the outcome of our study may provide the rationale to develop small molecule modulators of KCa3.1/KCa2.X for the treatment of cerebrovascular and neurological disease.

Keywords: cerebral ischemia,neurodegenerative disorders,alzheimers disease,diabetes,endothelium,microglia,potassium channel,neuroprotection,animal models,small molecule
Understanding Symbiotic Diversity: aCandidate Gene approach (SYM'S GENE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-06-01
End date: 2017-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Interaction between plant root and arbuscular mycorrhiza (AM) is a crucial symbiosis in nature and present in almost all crops. In addressing plant responses to stress, this proposal shifts the focus from the host to the symbiotic unit. By recognizing symbiosis to be a major player in evolution, the interplay is valued between the adaptive regulation of host and symbionts metabolisms. Using wild carrots, their AM community and the alternatieve oxidase (AOX) candidate gene, the researcher will address the prediction that AOX gene polymorphisms are drivers in interlinked plant and AM fungi evolution. This project studies - for the first time - the interaction between plant and AM in natural ecosystems using a crucial candidate marker, followed by experiments exploring driving effects of evolution. The research will lead to better understanding of evolutionary processes that shape the composition of the symbiosis and of the benefit of diversity to crop productivity. The approach is interdisciplinary: physiology, ecology and evolutionary genetic methodologies. There is high commercial interest in appropriate breeding strategies based on efficient genotype-mycorrhiza as they can promote, a.o., a more sustainable use of phosphorus in crops and minimize associated biodiversity losses, and mitigate the impacts of global climate change on agricultural and native plant communities. A similar proposal was previously submitted in 2011-CIG which achieved overall high scores. The present proposal addresses the referees’ comments, which mainly concerned better explanation of the methodologies and their feasibility. The researcher’s profile closely matches the project needs, and her independent thinking and entrepreneurship, together with the high academic profile of the host Marie-Curie chair, provide a strong foundation for successful implementation of this project and long-term integration of the researcher.

Keywords: l810 symbiosis,l803 systems evolution - biological adaptation - phylogenetics - systematics,l813 agriculture related to crop production,aox,genotype-mycorrhiza interaction,abiotic stress
Concise Synthesis of Tricyclic Angularly Fused Natural Products via Controlled Cyclizations of a Common Key Precursor: Preparation of Alliacanes, Arteannuins, Pentalenolactones and Triquinanes (UNIQUE PRECURSOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A general and highly efficient diversity-oriented synthesis of tricyclic angularly fused-structured natural products, such as arteannuins, alliacanes, pentalenolactones and triquinanes, via selective cyclization from a common precursor is proposed. The outlined synthetic methodology offers conceptually novel perspective, enabling to deliver multiple targets via cascade sequence of controlled intramolecular reactions from a common easily accessible key precursor; thus, providing simplified access to numerous classes of natural products, pharmaceutically important molecules and new potential therapeutic agents and drug candidates. Apparently, the mere existence of similar fundamental core structures is not exclusive to chemical compounds extracted from the same natural source. Common or highly resembling core structures were identified throughout various forms of life, such as different (and often distantly related) families of plants, as well as corals, fungi and bacteria. Examples include modern drugs and natural products derived from a broad spectrum of biological sources, such as Alliacol A, Artemisinine, Pentalenolactone P, Arteannuin M, and many others that share the tricyclic angularly fused ring systems. Even though previously developed synthetic methodologies towards the construction of the above mentioned molecules exist, the generality of our strategy and the ability to utilize simple and readily accessible precursors, will uncover rapid and efficient synthetic pathways to result in a wide range of natural products.

Keywords: organic chemistry,total synthesis,natural products,c111 method development in chemistry,c112 catalysis,drug candidates,controlled cascade reactions