Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Aluminium oxide integrated photonic platform for applications in the ultraviolet (UV) (ALUVia)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,France,Switzerland
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2022-12-01
End date: 2026-01-31
Duration (months): 38.0
Total project cost (EUR): 2054755.0
EU funding (EUR): 2054755.0
Participants: 3
Project status: SIGNED

The goal of ALUVia is to establish the first European Al2O3-on-SiO2 (aluminum oxide on silicon dioxide) integrated photonic platform for operation in the ultraviolet (UV) wavelength region. The platform will be commercialized as a foundry service via the spin-off company of the PI’s group, Aluvia Photonics B.V., which is founded in the framework of the ERC Proof-of-concept project aSINdo. The platform will contain a comprehensive library of widely deployable building blocks that will be offered commercially. An integrated photonic packaging technology will be developed for operation down to ultraviolet wavelengths. As a test-base and driver for the developed building blocks and packaging technology, we will utilize the ALUVia platform in two application fields that have promising commercial and scientific potential, namely (1) an integrated sensor for UV (resonant) Raman spectroscopy and (2) an integrated multiple-ion trap for the parallelization of on-chip quantum qubit generation, one of the most advanced quantum computing technologies today.

Keywords: integrated photonics al2o3 process design kit waveguides uv wavelength
Automated production process for next-level redox flow battery stacks and modules following a revolutionary different and cost-optimised production approach (Clean(S)tack)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-04-30
Duration (months): 27.0
Total project cost (EUR): 2426250.0
EU funding (EUR): 1680875.0
Participants: 1
Project status: CLOSED

To meet climate targets, the worldwide increase of renewable energies is inevitable. While the increase of renewables in the past years was backed-up with fossil fuel-based generators, the future electricity generation systems will rely on CO2-free energy storage devices to bridge the shortfall-times from wind and solar. Consequently, efficient use of renewables goes hand in hand with cost-efficient and reliable long-duration stationary storage systems. The new markets for long-duration stationary storage systems demand lowest cost per cycle (LCOS), sustainability and safety. These criteria are at best fulfilled by redox flow batteries. VANEVO (https://www.vanevo.de/home) invented new components for various kind of redox flow batteries – including future concepts. VANEVO patented a revolutionary different innovate battery stack assembly process with significant cost reductions and intends to automate the stack and module production for redox flow batteries.

Keywords: redox flow batteries,stationary energy storage technologies,stacks,renewable electricity systems,sealing technologies
Nanofluidics for label-free detection of exosomes and protein aggregates in neurodegenerative disease research (EXO-CHIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: CLOSED

Microfluidics have become a powerful tool in biotechnology and life sciences, whereas the nanofluidic regime remains widely unused in industry and the clinical environment. Especially protein misfolding diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease, recently experience a growing demand for single-molecule detection capabilities, as the assembly process of a single corrupted protein is correlated with its aggregation propensity and spread of the disease. Conventional microfluidic methods to study relevant biomarkers and aggregates involve fluorescent labelling, which alters the samples' properties and puts additional constraints on experimental design. We therefore seek for methods to study macromolecules (in particular: exosomes, oligomers) in a label-free manner in solution without chemically altering their properties. To overcome this limitation, the project combines innovative nanofluidic technology with cutting-edge label-free microscopy techniques. First, hybrid 2-photon lithography is used for the scalable cost-effective nanofabrication of nanofluidic polymer chips. Secondly, these chips are then employed for the detection and sizing of exosomes (<100 nm) and alpha-synuclein protein aggregates (<12 nm) in solution using label-free imaging methods (e.g. QPM and DUVM). The approach presented here, allows protein misfolding researchers to study oligomerization more efficiently by running orders of magnitude more experiments with same already limited material, and greatly increases availability of nanofluidic chips for protein metrology in existing biological laboratories. New expertise, excellence, management skills and scientific training acquired during the action, prepare the researcher for a role as independent dementia research group leader in Europe, using state-of-the-art nanotechnology to establish nanofluidic single-molecule detection of protein aggregates and macromolecules as new golden golden standard in life sciences research.

Keywords: nanofluidics two photon lithography label free microscopy quantitative phase microscopy protein aggregation exosomes alpha synuclein tau
Predicting the impacts of river reconnection, biological invasions and climate change for the conservation of endangered cold-water fishes in Europe (DIRECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-04
End date: 2027-08-03
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

River fragmentation and biological invasions are driving extirpations of cold-water fishes in Europe, with extirpations exacerbated by climate change. River barriers that cause fragmentation can prevent invasive species from dispersing further upstream (by forming an impermeable invasion front), but also impede the upstream movements of cold-water fishes (such as salmonid fishes), preventing their access to cooler waters towards the headwaters. The facilitation of movements of salmonids above barriers can be achieved through building fish passes on the structure, providing an easier route upstream, but this also opens up the invasion front for the invasive species. This Action explores this conservation disjuncture between alleviating river fragmentation through fish pass construction that aims to conserve threatened populations of cold-water fishes through reconnection and access to cool waters versus the fish passes opening up the extant invasion front to a highly invasive and impacting fish. Using the River Teme, Western England, as our study system, European barbel Barbus barbus as the model invader, and brown trout Salmo trutta and endangered Atlantic salmon Salmo salar as the model cold-water salmonid fishes, our objectives are to (i) compare and contrast the spatial and thermal ecology of barbel at the invasion front versus their core range, and identify the risk of their upstream dispersal over barriers via fish passes according to phenotypic variability; (ii) quantify the ecological interactions of salmonids and barbel throughout the study river and across different population abundances; and (ii) develop novel predictive models that predict conservation outcomes by simulating how river management schemes to promote salmonid conservation might instead drive the further invasion of a highly invasive fish. The Action has high complementarity between its outstanding European researcher and his host research group with expertise in fish invasion ecology.

Keywords: acoustic biotelemetry,biological invasion
Exploring Tipping Points and Their Impacts Using Earth System Models (TipESM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Denmark,Sweden,France,United Kingdom,Switzerland,Netherlands,Norway,Germany,Spain
Call: Climate-related tipping points (HORIZON-CL5-2023-D1-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4864470.59
EU funding (EUR): 4864470.59
Participants: 15
Project status: SIGNED

TipESM brings together scientists from a range of disciplines to deliver a step change in our understanding of climate tipping points in the Earth system, including their impact on ecosystems and society, combined with a set of early warning indicators and safe future emission pathways that minimise the risk of exceeding such tipping points. TipESM assembles the latest Earth System Models (ESMs), including recent improvements to key processes: ice sheets, vegetation and land use, permafrost, marine and terrestrial biogeochemistry. In cooperation with the WCRP/Future-Earth project TIPMIP, TipESM will organise an international collaboration to design and realise a common ESM experiment protocol that will facilitate analysis of the likelihood of occurrence, and potential reversibility, of tipping elements at different levels and duration of global warming. These experiments, will be combined with more project-specific ESM experiments, designed to investigate interactions and feedbacks across the Earth system. Based on the TipESM experiments, existing simulations and observations, we will investigate tipping points, their driving processes, potential early warning signals and cascading effects across the climate, ecosystems and society. Including the most important components of the Earth system in our ESMs will also allow TipESM to identify potentially unknown tipping elements, their precursors and impacts. TipESM brings together expertise from climate science and climate impacts to investigate both the role of gradual climate change for tipping in individual ecosystems and society, and the impact of crossing specific climate tipping points for society, ecosystems, and biodiversity. Project findings will be synthesised into a tipping points risk register. New knowledge and data from TipESM will be regularly communicated to a broad range of research communities, policymakers and the public, contributing to a prepared and resilient society.

Keywords: tipping points in the earth system,earth system modelling,early warning indicators,tipping point risk register,cascades across tipping elements,ecosystem and societal tipping and impacts
A History of European Christian Anti-Antisemitism 1945-2020 (Christosemitism)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1700000.0
EU funding (EUR): 1700000.0
Participants: 1
Project status: SIGNED

This project sets out to study the history of the Roman-Catholic and the Protestant repudiation of antisemitism, which I call Christian anti-antisemitism, in Western Europe between 1945 and 2020. Through its expression in multiple ecclesial declarations, theological works, liturgical events, educational projects, and professional appointments, I argue that anti-antisemitism is a core component of contemporary European Christianity. As such, it is inherently tied to the reconfiguration of Western Christianity in late 20th and early 21st century in the context of the liberal secular society, to the creation of orthodoxies and heresies, and to processes of secularization, decolonization, and the globalization of Christianity. To grasp the role of Christian anti-antisemitism within these processes, the project will explore three of its central aspects: First, the project will analyze the penetration of anti-antisemitism into the center of Christian European identity by examining its key theological concepts and historical development. Second, the project will explore Christian anti-antisemitism as it was consolidated and negotiated in interaction with Jewish interlocutors, and the dialectic combination between severe disagreements between Jews and Christians on the nature of antisemitism and the role of Christians in facilitating and perpetuating it, and between fruitful anti-antisemitic collaborations that were also recruited for the cultivation of Europe’s postwar liberal ethos. Third, the project will study intra-Christian debates on antisemitism in ecumenical and global Christian settings, and investigate the place of anti-antisemitism within tensions between Western Christianity and World Christianity around racism and colonialism. Based on its findings, Christosemitism will suggest a new theoretical paradigm through which to grasp Christianity’s role in contemporary Europe, as well as that of religious phenomena in the history of secular societies more broadly.
Intelligent and self-adaptive decision support system for optimization considering sustainable value creation and life-cycle approaches in Shipping (NEREUS-Shipping)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 3
Project status: SIGNED

Despite its growth, the shipping sector's sustainability transition lags compared to other sectors. If left unchecked, a 90-130% increase in emissions by 2050 is forecasted with significant socio-economic impacts. Though regulatory changes are emerging, many criticize them for their narrow scope and lack of ambition; lacking a clear approach that embodies ocean, air, and marine ecology preservation. NEREUS-Shipping aims to develop a comprehensive and self-learning decision support system (DSS) based on sustainability, circularity and risk metrics following a lifecycle approach to highlight how short-term operational decisions can affect the long-term sustainability of the vessel. Using the proposed tool, stakeholders will be able to obtain vessel-specific suggestions for risk reduction considering environmental, social and commercial goals. NEREUS-Shipping stands out for its novel approach of integrating tools that were up till now employed in silos within a novel dynamic framework to offer a practical and cost-efficient solution that combines lifecycle assessment, data analytics, risk mapping, and real-time data. This tool will become an effective DSS for identifying sustainability and circularity opportunities while its dynamic nature will allow updating of the metrics using vessel performance and supply chain data. Under this MSCA program, the Fellow will join one of Europe’s most advanced teams on Environmental Engineering and Circular Economy (National Technical University of Athens) with further complimentary training in two other EU academic institutes (Technical University of Crete and Technical University of Denmark) and collaborate with industrial partners. During the project the fellow will gain knowledge on sustainability, risk modelling, decision making, cyber-physical systems and digital tools while also expanding his collaboration network. The results will make educational and social impact through engagement with academic institutions and the public.

Keywords: sustainability,circularity,digital twinning,decision support system for vessel operations,digital product passport,life cycle assessment,
Enhancing Tensor Network Approaches for Rydberg Atom Quantum Simulators (ETNA4Ryd)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 267805.2
EU funding (EUR): 267805.2
Participants: 2
Project status: SIGNED

Recent experiments with ultracold atoms, trapped ions, Rydberg atoms, and superconducting circuits succeeded in realizing quantum many-body states at unprecedented sizes and thus investigating their static and dynamical properties. These achievements have boosted the search for protocols to observe exotic phases of matter in quantum simulators and to implement quantum computations unaffordable for classical supercomputers. I aim to investigate Rydberg-atom platforms, improving their efficiency for future quantum simulation and computation tasks, motivated by their versatility and manipulation capability. Classical numerical simulations are fundamental to developing quantum simulators, engineering efficient experimental protocols, and benchmarking the results. Still, an exact representation for large quantum many-body states is highly inefficient and impossible to achieve for the sizes available in current experiments. I will exploit advanced numerical tensor network methods to simulate the out-of-equilibrium properties of highly constrained quantum phases, as topological spin glasses and quantum scars, recently realized on Rydberg-atom high-dimensional lattices. Indeed, tensor networks are a balanced approximation between accuracy and computational resources and are the ideal set of tools to investigate constrained regimes in quantum many-body systems. Realizing this project first at the Lukin Quantum Optics Group at Harvard University and then at theQuantum Theory Group at Padova University, I will access world-leading experimental and numerical expertise to perform cutting-edge analytical, numerical, and experimental investigations on Rydberg atom platforms. In addition, I will acquire experiment modeling expertise and apply them at the near-future quantum computation laboratory at Padova University. This project is aligned with the Quantum Technologies Flagship, making me valuable for future innovative research on competitive quantum technologies applications.

Keywords: quantum many body systems,tensor network numerical simulations,quantum simulation and computation,rydberg atom experiments
Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes (HappyMums)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Spain,Denmark,Finland,Germany,Croatia,United Kingdom,United States,Poland,Switzerland
Call: Towards a molecular and neurobiological understanding of mental health and mental illness for the benefit of citizens and patients (HORIZON-HLTH-2021-STAYHLTH-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 8925244.75
EU funding (EUR): 8925241.0
Participants: 17
Project status: SIGNED

HappyMums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy, and the efficacy of interventions. It will interrogate a large collection of cohorts with multiple biological, medical, clinical, socio-demographic and environmental and lifestyle data to identify the most robust risk factors triggering depressive symptoms, but also moderators of the risk. By putting together unique human samples of placenta, chorionic villi and amniotic fluid, and animal models, HappyMums will improve the understanding of the neurobiological mechanisms affected by depressive symptoms in pregnancy that lead to alterations in the foetal environment, shaping offspring risk for developing negative mental outcomes. The use of three complimentary rodent models will allow to achieve a proof of causality, and the presence of an innovative fish model will elucidate the mechanisms specific to placenta by which adverse maternal conditions are transmitted to the offspring without the potentially confounding mitigating effects of compensatory postnatal maternal care. This knowledge will allow the identification of new targets for the development of novel medications, for the repurposing of existing medications or for the development of non-pharmacological interventions. HappyMums will also develop a digital platform where AI tools-based data can be collected, together with biological, clinical, medical, environmental and lifestyle data, through a mobile phone App that will be at the interface with clinicians via a dedicated dashboard. This will allow early screening of depressive symptoms, prompt diagnoses, personalized treatments, and the promotion of protective lifestyle attitudes. Overall, HappyMums will not only increase the knowledge in the field of mental disorders in pregnancy, but also improve the wellbeing of these women, providing unprecedented benefits also to the offspring and thus to society at large.

Keywords: depression symptoms in pregnancy,in utero programming,epigenetics,risk factors and moderators animal models,fish models