Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How Deforestation is Changing the Climate and Atmospheric Chemistry over Amazonia (DECCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

The Amazon rainforest, renowned as the world's largest, plays a pivotal role in biodiversity, water cycles, atmospheric chemistry, and global climate. However, this vital ecosystem is progressively succumbing to vulnerabilities triggered by climate change and deforestation. Main drivers of deforestation are the expansion of pasture and agriculture. Over the past decade, these activities have surged, underscoring the pressing need for a scientific comprehension of the impacts of deforestation across Amazonia. To tackle this challenge, DECCA is adopting a multifaceted approach. First, through rigorous laboratory investigations, DECCA is scrutinizing the impacts of deforestation types on soil microbial community distribution, along with emissions of greenhouse gases (GHGs, carbon dioxide+methane+nitrous oxide) and reactive nitrogen (Nr, nitrous acid+nitrogen oxides+ammonia). By analyzing soil samples from different land use categories—ranging from pristine forests to areas converted to livestock and agricultural use—DECCA aims to quantify GHGs and Nr fluxes. This initiative encompasses an exploration of the influencing factors that drive GHGs and Nr emissions, ultimately enabling the establishment of emission parameters. Second, combined with a chemistry-transport model, DECCA quantifies the impact of deforestation on atmospheric chemistry and composition. This extends to understanding the formation of critical elements like ozone, aerosols, and cloud condensation nuclei. Third, a process-based biogeochemistry model is employed to estimate total GHG emissions for understanding GHG budgets and their climate implications. Moreover, DECCA incorporates predictions of land use evolution up to 2050, enabling supplementary model simulations for future deforestation scenarios. Thus, DECCA leads an interdisciplinary endeavor, enhancing our grasp of deforestation impacts across molecular, ecosystem-wide, and atmospheric scales.

Keywords: atmospheric chemistry climate change amazon rainforest deforestamazon rainforest soil emissions nitrogen oxides nitrous acid atmospheric chemistry aerosol ozone climate change deforestation
ReIonization and Signatures of Early Stars (RISES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499478.0
EU funding (EUR): 1499478.0
Participants: 1
Project status: SIGNED

Understanding how the first stars and galaxies formed and drove the Universe's final phase transition by re-ionizing intergalactic hydrogen is one of the long-standing goals of extragalactic astronomy. In the past two decades, we have discovered this ``Epoch of Reionization'' ended around one billion years after the Big Bang (redshift, z < 6), but the process is still poorly understood. We are currently undergoing a radical shift in our ability to observe this epoch with the new James Webb Space Telescope (JWST). Early JWST observations have discovered a surprising excess of luminous z > 9 galaxies, implying stars may have formed differently in the early universe than we had previously expected. However, we can only observe the brightest galaxies directly. Enhanced star formation in the bulk of the early galaxy population should have produced an early start to reionization, but this is still very poorly constrained observationally. Excitingly, JWST finally enables us to chart reionization out to its earliest stages and infer the properties of the first stars. In RISES, I propose to analyse groundbreaking new datasets I am accruing as PI on JWST with state-of-the-art statistical inference frameworks to connect observations of the bright galaxies visible with JWST to the evolution of the intergalactic medium. The key aims of this proposal are to: (1) test what drove the enhancement of star formation in the first bright galaxies; (2) establish when reionization began, to infer whether star formation was enhanced in the bulk of early galaxies; and (3) understand how reionization proceeded by connecting galaxies to ionized regions for the first time. These measurements will push the boundaries of our knowledge of structure formation in the early universe, and enable potential breakthroughs in our understanding of the formation of the first galaxies, the regulation of star formation at the highest redshifts and the evolution of the intergalactic medium.

Keywords: reionization,high redshift galaxies
Mapping of Longitudinal data of Inequalities in Education (MapIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Norway,Sweden,Hungary,Germany
Call: Mapping of longitudinal data and assessment of inequalities in education, training and learning achievements (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2699644.75
EU funding (EUR): 2699644.75
Participants: 9
Project status: SIGNED

The MapIE project aims to identify mechanisms causing educational inequalities and policies or interventions compensating for them. We do a systematic review of how these have been studied internationally using longitudinal designs. We map existing longitudinal data that we describe in a public metadata database, and we analyse them to describe the mechanisms of inequalities and to identify effective policies and interventions in different local contexts. We focus on the contextual differences between the Nordic and Central European countries that have structurally different education systems. Within national contexts and using comparative research designs, we look at system-, regional- and school-level policies and practices and individual-level factors (e.g. socioeconomic status, immigrant background, gender, special educational needs) that are associated with the development of educational inequalities and the successful prevention of achievement gaps. We publish and disseminate the empirical results of the project through multiple channels to scientific audiences, policy makers and the wider public. At the end, we create a public framework for studying educational inequalities longitudinally in future studies, acknowledging the role of local contexts but aiming for comparability at the European level. We implement the project in seven work packages. Our consortium consists of internationally acknowledged experts in large-scale educational assessment research from Finland, Sweden, Norway, Hungary and Luxembourg/Germany. The partners have a long-standing history of collaboration with each other, European researchers, and national and international education policy makers, and they bring extensive longitudinal datasets to the project. The project will considerably strengthen the knowledge base of what shapes educational outcomes over time, how to best support the learning of all students and how to reduce education inequalities in the short, medium and long term.

Keywords: learning achievements,educational inequalities,data mapping,longitudinal data,gender,socio economic background,immigrant background,intervention,compensation of educational inequalities
In vitro 3D cell models of healthy and OSTEOpathological ageing bone tissue for implantation and drug testing in a multidisciplinary NETwork (OSTEONET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Belgium,Israel,Germany,Greece,Austria,Poland,France,Norway
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1778885.71
EU funding (EUR): 1467400.0
Participants: 16
Project status: SIGNED

OSTEONET aims to (i) build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable 3D in vitro cell models of healthy and aged bone tissue and (ii) train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of ageing on bone biology and mechanobiology, and on bone response to drugs, to leverage the use of 3D cell models in clinics and basic/industrial research labs. Bone ageing reduces the quality of life of the elderly and puts social and economic burden on society. Ageing bones fail more easily when challenged mechanically or with toxicants or pollutants, and respond differently to drugs than healthy bone. To personalize therapies and enable better preventive care for the elderly it is essential to develop reliable and sustainable in vitro models of aged bone tissue alternative to animal tests which often fail to capture human-specific features. Several scientific studies support the idea that in vitro models of bone tissue are an outstanding resource for (i) the comprehension of bone physiology, (ii) a better understanding of pathological pathways in most bone dysfunctions, (iii) testing new or repurposed drugs for bone treatment before preclinical trials with animal models. The networking activities planned in OSTEONET will unravel and share knowledge on the mechanisms driving the information transfer from the biochemical and biomechanical levels, which drive osteosynthesis and osseointegration, to the cascade of molecular and cellular events emerging as an elaborated and physiological bone, and on the mechanisms of the different response of healthy and aged bone tissue to mechano-biological stimuli and drugs.

Keywords: bone,bone pathologies,tissue engineering,cell cultures,bioreactors,microct,material microproperties,osteoporosis,computational medicine,personalized medicine
Deep multiplexed epigenetic profiling of plasma cell-free nucleosomes for early cancer diagnostics (OncoID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Over recent years, cancer diagnostics based on cell-free DNA (cfDNA) in liquid biopsies demonstrated great promise in guiding treatment and screening for recurrent diseases. Current diagnostic strategies are mainly based on the analyses of DNA mutations, fragment length or DNA methylation status. However, these strategies do not provide a universal approach for cancer identification, are costly and labour intensive, and generally fall short in detecting cancer at early tumorigenic stages or minimal residual disease. An underexplored field, is the development of diagnostic applications based on histone post-translational modifications (PTMs). The strategy to harness these epigenetic signatures to identify cell-of-origin is potentially superior over state-of-the art methods because it offers targeted and multiplexed amplifications of exclusively informative genomic regions (i.e. promoters and enhancers). Such strategies are cost-effective and display much increased sensitivity over existing methods in their accuracy in e.g. early cancer diagnoses, relapse detection or screenings. Unfortunately, the development of this field is hampered by a lack of methods that are sensitive enough to detect multilayered histone PTM-signatures in samples with limited material such as blood plasma. This proposal describes our plan to implement two new strategies, for ultra-sensitive detection of multi-layered histone PTMs signatures in blood plasma. Our proposal outlines 1) a research plan for the implementation and optimization of these strategies to profile histone PTM profiles in plasma of healthy and patient material to determine the diagnostic potential of the method and 2) develop a market strategy and navigate product development opportunities for commercialization of the method. Successful execution of this proposal will result in the establishment of a novel diagnostic strategy with unprecedented potential for universal cancer screening-approaches based on liquid biopsies.

Keywords: cell free dna,epigenetics,cancer diagnostics
iMmersive gamEs for Museums as vehicles to Engage visiTOrs in Empathetic reSponses (MEMENTOES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Czechia,Austria,Ireland,Belgium,Netherlands
Call: Preserving and enhancing cultural heritage with advanced digital technologies (HORIZON-CL2-2021-HERITAGE-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3295253.75
EU funding (EUR): 3295253.5
Participants: 8
Project status: SIGNED

MEMENTOES will build immersive video games to service the needs, and facilitate mass audience affection for museums engaged in the topics of memorialisation and transitional justice. The goal is to create authentic storytelling experiences, where people, places and original items, are used to maximum effect to fulfill the museum’s responsibility to provide immersive, deeply personal experiences that aim to demonstrate empathy toward their communities. Through cutting-edge technology, such as virtual/mixed reality,high-quality digitisation techniques, AI for explorative procedural content generation, and accessible interaction techniques, MEMENTOES will deliver a universal experience where distant people and places will become palpable and present to the players. MEMENTOES will involve a multi-disciplinary team of museum curators, designers and exhibit developers, as well as technology providers and visionary game developers so as to uncover the types of connections museum visitors are making, enabling the game makers to understand the types of education techniques and behaviors that foster historical empathy and tangential learning outcomes and draw appropriate parallels to game storytelling frameworks. Three game will be developed, each targeting an authentic museum recognised internationally as a Site of Conscience, to help get deliver the museum messages to wider audiences from around the world, transcending even the boundaries put in place by the recent COVID-19 pandemic. MEMENTOES will further facilitate a liaison with the outcomes of HORIZON-CL2-HERITAGE-2021-01-09: ‘Games and culture shaping our society’, contributing with its evidence on games as a vehicle to engage cultural institution visitors in empathetic responses.

Keywords: video games,serious games,tangential learning,historical empathy,virtual reality,mixed reality,procedural content generation,digitisation,accessibility,super resolution imaging
Targeting Cancer with ERV Vaccines (CancERVacc)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-07-01
End date: 2025-10-31
Duration (months): 40.0
Total project cost (EUR): 12179813.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

InProTher (IPT) is developing a unique immunotherapy – BreakImmune – that effectively targets endogenous retroviruses (HERVs) to treat cancer. HERVs are not expressed in normal tissues, but are expressed in several major cancers, such as breast (88%), prostate (90%), ovarian (90%), and pancreatic (80%). Thus, HERVs can be a potential target for the immune system to destroy tumor cells. IPT technology relies on the engineering of HERVK antigens to be used as effective cancer vaccines. The administration of BreakImmune, the mutated HERVK in Ad19/MVA viral vectors, induces both strong antibody and T-cell immune responses able to destroy cancer cells in multiple cancer types. Our first product is IPT001, a first in class vaccine against solid cancers in combination with checkpoint inhibitors.

Keywords: immunotherapy,breast cancer,prostate cancer,pancreatic cancer,therapeutic vaccines,endogenous retrovirus
Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders (SecretAutism)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1997729.0
EU funding (EUR): 1997729.0
Participants: 1
Project status: SIGNED

Since the ancient Egyptians, the fluid in the brain has been considered a product of spirits, a pathological signature or inert liquid. Even at the turn of the 19th century, when the cerebrospinal fluid (CSF) was first described as a physiological substance, the CSF and the interstitial fluid (ISF), the fluid surrounding all the cells of the brain, were considered solely as a cushion. Only more recently studies have begun to show that the compositions of these fluids can have a marked impact on brain development and animal behaviour. A number of studies have employed omics to demonstrate that the ISF and the CSF are rich in secreted proteins, RNAs and metabolites. However, it is still unclear how these factors influence the development and the function of the brain. Here, we will take a systematic approach to advance our knowledge about the role of extracellular proteins in the brain in health and disease. Using knowhow in studying the causes of autism spectrum disorders (ASDs) my lab will study the effects of changes in the composition of the extracellular space of the brain at unprecedented resolution and scale. Specifically, we aim to 1) functionally identify proteins of the extracellular space that modulate neural development; 2) study proteins that are packaged into extracellular vesicles and whose mutations are considered high ASD-risk factors; 3) analyse -in vivo- the function of HNRNP U, an RNA-binding protein, which we identified in brain extracellular vesicles and whose mutations are tightly linked to neurodevelopmental disorders. This endeavour will represent an important step toward a better understanding of the role of extracellular factors in brain development and function. My work will highlight an entire class of protein encoding genes that crucially contribute to neural development by a previously underappreciated pathway, i.e. through the extracellular parenchyma and that when altered lead to forms of ASDs which may be more amenable to treatment.

Keywords: autism spectrum disorders,extracellular proteome
Integrated High-speed Power Systems for Industry and Mobile Applications (HIPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Germany,Sweden,Denmark,Italy,Slovenia,Austria
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2846275.2
EU funding (EUR): 2846275.2
Participants: 12
Project status: SIGNED

This DN implements a multidisciplinary and innovative research and training programme, bringing together different scientific fields and industrial participation to enable a new generation of Doctoral Candidates (DCs) to investigate and develop electric drives in the context of electrification in the transition towards zero-emissions. Electrification is one of the key assets in green transition and future sustainable world. While electrification offers one of the main solutions in reaching carbon-neutral societies, there is already now a lack of skilled persons in the field. Therefore there is an urgent need to educate young highly skilled engineers with a breadth of interdisciplinarity on designing propulsion machines and power converters to become EU’s future leaders in power electronic systems (applied in renewable energy systems and electric vehicles - EVs). The proposed network is timely in meeting the challenges, bringing together the leading experts and providing best training opportunities to doctoral candidates (DC). This will make a step change in the EU’s key industry with potential impacts on other applications such as high-speed trains, electric vehicles, electric aircrafts and ships. High-speed technology enables high material and energy efficiency. Therefore, HIPO (integrated HIgh-speed POwer systems for industry and mobile applications) research and training programme will focus on providing Doctoral Candidates (DCs) with relevant knowledge, methods and skills across a wide range of disciplines around Electric High-Speed Drives.