Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Stimuli-Responsive Two-Dimensional Materials for Renewable Energy (2DMAT4ENERGY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-18
End date: 2020-09-17
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 2
Project status: CLOSED

I will engineer van der Waals (vdW) heterostructures of two-dimensional (2D) materials with tuneable electrochemical response for exploitation in renewable energy applications. These heterostructures, which are constructed by stacking 2D crystals on top of each other, have been attracting increasing attention in solid-state physics, optoelectronics, and photonics but their full potential in electrochemical applications such as energy storage, conversion, and sensing remains completely unexploited. I will control their electrochemical response by external stimuli including electric field, strain, and illumination. In order to succeed, I will first develop a solid understanding of the unexplored key electrochemical properties of 2D materials and their dependence on these stimuli. I will fully exploit my recent experience in 2D materials’ research and the access to the world-class nanofabrication and characterisation facilities and scientific expertise at Cornell University, the University of Manchester, and National Physical Laboratory. This research is motivated by the ever-increasing need for reliable sources of renewable energy, which will provide clean and inexpensive electric energy and address the irreversible depletion of fossil fuels. However, the intermittent nature of renewables (day-night, tidal, and weather cycles) does not permit on-demand supply of electricity. Energy conversion and storage technologies, whose majority relies on electrochemical interfaces, balance this ‘demand vs. supply’ mismatch and prevent energy wastage. The topic of my fellowship is in an excellent alignment with the long-term research strategies within the Horizon 2020 and Graphene Flagship EU programmes. The proposed research will have a significant impact on target areas of EU energy policy, i.e. the 2030 Energy Strategy and Horizon 2020 research programme: namely the 27% of energy consumption from renewable sources and 27% of energy savings while meeting the current demands.

Keywords: graphene,mos2,2d materials,van der waals heterostructures,nanofabrication,electron tunnelling,energy storage,tuneable electrochemistry,energy conversion,sensors,renewable energy
Social Distress Response in the Context of Empathy in Rats (SOCIORATS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Why do humans behave pro-socially to such an extent that it supports the life of other individuals? Similarly, why do certain people harm others by hurting and sometimes killing? Finally, how can we promote pro-sociality and limit harmful actions? The philosopher and economist Adam Smith considered that what motivates us to help a person is that we can “place ourselves in his situation, we conceive ourselves enduring all the same torments", thus, holding empathy as the driving force of prosociality. Human neuroimaging studies show that two brain structures, the anterior insula (AI) and the rostral cingulate cortex (rCC), are involved in empathy. Yet, it remains unknown whether these structures are involved in consequent behaviors, i.e., helping or hurting others. With this fellowship, I intend to fill this gap: I propose an approach to causally test Adam Smith's theory, which will produce findings of tangible societal benefits by informing populations worldwide whether prosocial programs can limit fighting and bullying, and by providing novel pharmacological targets for the treatment anti-social disorders. Because human neuroimaging is severely limited in its ability to establish causal links between brain activity and behavior, we will use a rat model to study empathy-driven prosociality. Considering that a suited rodent model is completely lacking in the field, we will develop a paradigm where actor rats choose between two levers; while both yield the same reward, one requires more effort to be activated. Once preference for the easy lever has been quantified, it will be paired with an electric shock delivered to another rat. The impact of social distress on the actor's choice will provide a way to study prosocial and aggressive behavior. In a second time, we will deactivate the rCC and AI in order to causally explore the role of each structure in prosociality. Finally, we will use calcium-imaging to map and characterize the neural networks involved.

Keywords: empathy,prosociality,aggression,social distress,anterior insula,rostral cingulate cortex
Ultrafast Laplace NMR (UFLNMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 2625000.0
EU funding (EUR): 2625000.0
Participants: 1
Project status: SIGNED

Laplace NMR (LNMR), comprising diffusion and relaxation NMR experiments, provides detailed information on the dynamics and chemical resolution of molecular systems, which is complementary to NMR spectra. Similarly to the traditional NMR spectroscopy, the information content of LNMR can be significantly enhanced by a multidimensional approach. The long experiment time and low sensitivity restrict the applicability of the multidimensional method, however. Based on spatial encoding of multidimensional data, we develop a broad range of single-scan LNMR experiments, constituting a new class of NMR experiments called ultrafast multidimensional LNMR. The method shortens the experiment time by one to three orders of magnitude as compared to the conventional method, offering unprecedented opportunity to study fast processes in real time. Furthermore, it enables boosting the sensitivity by several orders of magnitude by using nuclear spin hyperpolarization, which allows investigation of low-concentration samples. Ultrafast LNMR opens paradigm-breaking prospects in chemical, biochemical, geologic, archaeologic and medical analysis. LNMR can, e.g., provide unique information on the intra- and extracellular metabolic processes, including those of cancer cells, which facilitates diagnostics and helps to find efficient treatments, and it can be exploited in the development of new types of biosensors. Furthermore, the method reveals previously unobservable details about the phase behaviour of ionic liquids, gel and polymer formation, as well as catalysis, which are essential in understanding their performance in technological applications. LNMR is also applicable to portable, single-sided magnets, implying potential to raise the sensitivity of low-field NMR to a completely new level. This entails significant impact on mobile chemical and medical analysis. The low cost of the low-field facility renders advanced NMR analysis broadly available, even in developing countries.

Keywords: nmr spectroscopy,relaxation,diffusion,hyperpolarization
Succinate-induced leukemic stem cell formation via epigenetic remodeling of hematopoietic stem cell (SuccHSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-11
End date: 2024-03-10
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: SIGNED

In life, no matter how small, changes can have huge impact on its quality. For hematopoietic stem cells (HSC), similar can happen. Through minor shifts, from normal to pre-leukemic and finally leukemic phenotype, generation of leukemic stem cells (LSC) results in overt malignancy, such is acute myeloid leukemia (AML). Life quality of AML patients is severely impaired, even in “disease-free” state after the treatment. AML chemotherapy and stem cell transplant offers 5-year survival to only 20% of patients above age of sixty, 40% to the rest. Currently, a major clinical factor in AML onset and relapse are ever-present LSC. Mechanisms by which HSC turn into LSC, in their highly regulated environment, are still largely unknown, which is why new knowledge is needed to unveil this troubling issue. With the growing amount of data correlating chronic inflammation and onset of various types of malignancies, the SuccHSC project will explore the role of succinate, one of the major inflammation-induced effector molecules, in LSC formation by epigenetic remodeling of HSC. Chronic inflammation generates various molecules, which can be picked-up by bone marrow HSC. Chronic HSC activation leads to peripheral blood entering, myeloid skewing, self-renewal exaustion and even perhaps leukemia. On mechanistic side, HSC react to inflammatory mediators by elevated glycolysis, reduced oxygen and increased succinate. New succinate molecules can reach nucleus through mito-nuclear communication. Among other modifications, histones were shown to be modified with succinate, but yet with no known role. SuccHSC will explore histone succinylation and its effect on gene expression comparing leukemic and normal human samples biochemically, by ChIP-seq and by RNA-seq. Transgene succinate-dehydrogenase KO mice model, which accumulates succinate, will be used to confirm succinylation role in gene expression regulation and HSC transformation into pre-leukemic cell stage.

Keywords: chronic inflammation,hematopoietic stem cells,leukemic stem cells,hypoxia,mitochondria,metabolism,cell respiration,tca cycle,succinate,histones,epigenetic,succinylation,gene expression
Setting the Stage for Solar System Formation (S4F)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2021-01-31
Duration (months): 66.0
Total project cost (EUR): 1999659.0
EU funding (EUR): 1999659.0
Participants: 1
Project status: CLOSED

Low-mass stars like our Sun are formed in the centers of dark clouds of dust and gas that obscure their visible light. Deep observations at infrared and submillimeter wavelengths are uniquely suited to probe the inner regions of these young stellar objects and unravel their structures, as well as the physical and chemical processes involved. These earliest stages are particularly interesting because the properties of the deeply embedded objects reflect the star formation process itself and how it relates to its environment. It is for example during this stage that the final mass of the star and the properties of its disk – and thus ability to form planets – are determined. It is also during these stages that the first seeds for the chemical evolution of the protoplanetary disk are planted and where some complex organic, possibly prebiotic, molecules may be formed. I here apply for an ERC Consolidator Grant that will support an ambitious program to map the physics and chemistry of the early Solar System. The proposed research program intends to use new high resolution, high sensitivity observations from the Atacama Large Millimeter Array (ALMA) - including a number of recently approved large programs – coupled to state-of-the-art radiative transfer tools and theoretical simulations to address some of the key questions concerning the physics and chemistry of the earliest stages of the Solar System: How is the chemistry of the earliest protostellar stages related to the physical structure and evolution of the young stellar object and its surrounding environment? Which complex organic molecules are present in the inner regions of low-mass protostars? What are the chances the rich chemistry of the earliest stages is incorporated into planetary systems such as our own?
RMIT European Doctoral Innovators (REDI) Programme (REDI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 8895360.0
EU funding (EUR): 4447680.0
Participants: 1
Project status: SIGNED

The RMIT European Doctoral Innovators (REDI) Program seeks to significantly boost research links between Europe and Australia by creating an international, multidisciplinary network of academic and non-academic partners to offer unique intercontinental and intersectoral doctoral training opportunities for ESRs. RMIT’s hub in Barcelona will lead a network of 24 Hosting Partners across 11 countries and more than 40 supporting industry Partners to offer 41 doctoral positions in a wide variety of research fields spanning business, arts and sciences. All positions are based in Europe and provide for 12-month secondments to RMIT University in Melbourne and shorter stays or engagements with Industry Partners. Partners were selected for their exceptional training and supervisory methods, materials, and facilities, so the REDI program may offer the best conditions and opportunities to its enrolled ESRs. The entire cohort of REDI ESRs and their Supervisors will also gather annually at a 5-day event in Barcelona to establish a community of multidisciplinary and multicultural researchers through their engagement in transversal skills and training workshops, cultural and social events, and the exploration of inter-sectoral and interdisciplinary collaborations for responsible research and innovation. They will also share best practices in innovative doctoral training, particularly international and remote co-supervision. The ESRs will graduate (most with two degrees) with a wealth of intersectoral skills, experiences and relationships that will catapult them into whichever research career they choose to pursue. The agreements signed within the network are expected to generate further co-supervised positions, with a target of 160 in total, meaning REDI will have a significant impact on linking the EU-Au research areas and creating long-term institutional relationships committed to implementing and sharing best practices in the international co-supervision of doctoral researchers.

Keywords: australia,rmit,cotutelle
Development of highly efficient solution-processable blue organic light-emitting diodes based on liquid-crystalline thermally activated delayed fluorescent emitter materials (TADF-DLC-OLEDs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-02
End date: 2023-09-01
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Recent years have seen tremendous advances in the area of vacuum-deposited organic light-emitting diodes (OLEDs) and these are now commercialized as displays in small portable devices, flat-panel full-colour televisions, and solid-state lighting sources for the automotive industry. The state-of-the-art emitters in these devices consist of a combination of fluorescent and phosphorescent materials, each of which has weaknesses in terms of performance and sustainability. Thermally activated delayed fluorescent (TADF) emitters offer the potential to overcome these weaknesses. Vacuum-deposition fabrication processes are, however, both costly and materials-wasteful and it is also difficult and expensive to fabricate large-area pixels given the size of the evaporator. Solution-processed OLEDs addresses these detracting features of the fabrication process. The state-of-the-art solution-processed OLEDs, and in particular blue OLEDs typically show poor device performance both in terms of stability and external quantum efficiency (EQE) that is significantly worse than vacuum-deposited devices. This proposal addresses these specific issues using an innovative approach. We will develop solution-processable blue TADF emitters based on discotic liquid crystalline (DLC) molecules, which we contend will provide horizontal alignment in solution-processed films, something not possible at present, in order to improve the light-outcoupling efficiency and hence the EQE.

Keywords: organic semiconductors,luminescent materials,horizontal alignment,liquid crystals,delayed fluorescence,organic light emitting diodes,electroluminescent device,solution processing
Efficacy of Leveraging Endocrine Therapies for Renoprotection during Intensive Care (ELECTRIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 277259.52
EU funding (EUR): 277259.52
Participants: 2
Project status: SIGNED

On the intensive care unit, more than 50% of patients have acute kidney injury, and these patients suffer higher mortality and long-term morbidity. To date, no specific therapies exist to prevent or treat acute kidney injury on the intensive care unit. We now have two new endocrinologic agents, glucagon-like peptide-1 receptor agonists and sodium-glucose transport protein 2 inhibitors, able to protect patients with diabetes from chronic kidney disease. The objective of this action is to investigate whether the renoprotective mechanisms of these agents can reduce markers of acute kidney injury in patients on the intensive care unit. This action incorporates a highly sophisticated animal model for the essential invasive measurement of renal physiology. To translate these findings to the clinical situation, I will employ new and innovative measurement techniques such as urinary oxygenation, new kidney biomarkers and advanced renal imaging techniques to elucidate these renoprotective mechanisms in humans. The involved universities of Amsterdam and the University of Melbourne bring together world leading experts on acute kidney injury, endocrinologic therapies, and intensive care medicine. By connecting their expertise, this action will not only provide insight into the renoprotective properties of the studied interventions and so improve the outcome of patients, but also train me as a researcher able to improve renal outcomes beyond the scope of this action.

Keywords: intensive care medicine,nephrology
Dynamics of Trust and Distrust Creation in Internet Voting (ELECTRUST)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 149625.6
EU funding (EUR): 149625.6
Participants: 1
Project status: SIGNED

I-voting has been around for two decades now and yet it still fails to be widely implemented. One of the main motives is the citizens’ lack of trust in the technology and the people deployed to it. By considering distrust as an independent variable from trust, I explore how both constructs shape public discourse around I-voting (both the technology and its promoters), understood as a critical case for the escalation of the very same approach and potential conclusions to the research in e-government. In order to fulfil this goal, I will be based in Gdansk University of Technology - GUT (Poland), in the Department of Informatics in Management, under the supervision of Pr. Tomasz Janowski, with one secondment to the Fraunhofer FOKUS Institute (Germany), in the Competence Center Public IT, under the supervision of Pr. Peter Parycek. The project will develop 5 case studies, 4 based on 2 week study visits and a long study visit to New South Wales (Australia) under the supervision of Pr. Lemuria Carter (University of New South Wales). The experience in GUT and FOKUS Institute will add technical and legal expertise to the proposed approach; while the development of case studies will give data for the analysis of the process of creation of trust and distrust. Methodologically, I will map the emergence of discourses of trust and distrust in I-voting through discourse analysis and in-depth interviews with sociopolitical actors; later, Q-methodology will be used to understand which discourses the citizenry mostly shares. The project will provide strategic know-how on the dynamics of trust and distrust concerning I-voting’s acceptance.

Keywords: internet voting,voting technologies,trust,distrust