Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Collaborative Research Fellowships for a Responsive and Innovative Europe (CAROLINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-FP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-06-02
End date: 2022-06-01
Duration (months): 72.0
Total project cost (EUR): 9204000.0
EU funding (EUR): 4602000.0
Participants: 1
Project status: CLOSED

The CAROLINE Fellowship Programme proposed by the Irish Research Council (IRC) will provide a unique opportunity for researchers to further develop their skills, competencies and experience through inter-sectoral collaboration with NGOs and International Organisations (IO). Proposals will be invited from all disciplines that speak to the overarching theme of global sustainable development as set out under the United Nations 2030 Agenda for shared economic prosperity, social development, and environmental protection. CAROLINE will fund 50 experienced researchers across two modes; International Fellowships (three-year) and Irish Fellowships (two-year). The IRC, a national agency, funds excellent research across all disciplines. Unique aspects of CAROLINE include the European and global resonance of the overarching research theme, the inclusion of NGO and IO partners with the host research performing organisations, flexibility in secondments, comprehensive approaches to equal opportunities and gender aspects, and dedicated core training and career support activities. Research outcomes and activities of the CAROLINE Fellows will benefit Europe, given the significance of the theme to Europe 2020, e.g. in employment, climate change and energy, education, and poverty reduction. CAROLINE will deliver experienced researchers with enhanced skills in inter-sectoral and interdisciplinary research and better access to a wider set of future career opportunities. The IRC has built an impressive array of support for this proposal from stakeholders in Ireland, Europe and internationally, including research performing-organisations, NGOs, IOs and other partners.

Keywords: international organisations,global sustainability,social development,shared economic prosperity,environmental protection,health,peace,security,ireland
Synthetic Utilization of Photoredox-generated Electrophilic Radicals (SUPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The collective body of the Pharmaceutical industry and the Green Chemistry Institute of American Chemical Society defined radical chemistry without tin as one of the “key green chemistry research areas” in our time. While the toxicity of tin reagents is a clear disadvantage, the unique reactivity and selectivity they offer does not have any analogy in polar reactions. Photoredox catalysis is currently emerging as an environmentally benign entry to radical chemistry, and as a research area that offers many opportunities for the discovery of novel reactivity. Hydrogen atom transfer (HAT) is a particularly important concept within radical chemistry, a concept in part been explored with photoredox catalysis. Generation of HAT active radicals by means of photoredox catalysis have typically been performed via oxidation of suitable precursors. However, for many applications, this well-established approach experiences a general poor substrate scoop and is not compatible with further development. An alternative approach, initiated by reduction of suitable precursors is underdeveloped. This project aims to address this gap in the synthetic methodology by developing suitable photoredox auxiliaries able to mediate HAT initiated radical cascades. This strategy will provide easy access to N-centered radicals from simple starting materials, which in turn provides a unique opportunity to study and map the reactivity of N-centered radicals. This research action will ultimately give an unprecedented access to pharmaceutically relevant pyrolidines and broad classes of pyrrolizine and indolizidine scaffolds.

Keywords: photoredox catalysis,hydrogen atom transfer,heterocycles
Unveiling new B-, N- containing structures through photoredox catalysis (NewBorN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-31
End date: 2020-07-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

In the past decade, photoredox catalysis has emerged as a tremendously versatile process to generate reactive radical species in organic synthesis under very mild conditions. Meanwhile, the host group have developed a suite of transformations exploiting the fundamental chemistry of boron, many of which involve 1,2-metallate rearrangement of boronate complexes. In this proposal, we propose to merge the N-centred radicals generated through photoredox catalysis and 1,2-metallate rearrangements of vinyl boronate complexes to create an efficient new strategy for organic synthesis, which will lead to a novel three component reaction where new C–C and C–N bonds are formed in one-pot, providing a new synthetic avenue for the preparation of β-amino boronic esters. Moreover, intramolecular radical cyclizations followed by oxidative 1,2-migration will enable the stereoselective synthesis of diversely functionalized cyclic amines. The scope of these processes will be carefully investigated, and mechanistic studies will be carried out using advanced physical/chemical methods. These novel methodologies not only benefit from the formation of highly functionalized products bearing both synthetically versatile boronic ester and amino moieties, but also lay solid foundations for the development of this new field. Based on the significant antibacterial activity against Mycobacterium tuberculosis of β-amino boronic acids, a preliminary test of the biological activities of compounds obtained throughout the proposed research (both cyclic and linear β-amino-boronic acids) will be carried out in collaboration with AstraZeneca. By combining two major fields of endeavour, new chemistry will emerge with unique structures harbouring novel properties for exploitation. Furthermore this project will enable significant knowledge transfer between host and researcher, while forging new academic networks within the scientific community.

Keywords: photocatalysis,2 metallate rearrangement,radical amination,amino boronic ester
Disruptive Approaches to Atom-Light Interfaces (DAALI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Spain,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3020486.25
EU funding (EUR): 3020486.25
Participants: 7
Project status: SIGNED

Realizing an efficient, controllable interface between photons and atoms or atom-like emitters forms the basis for wide-ranging applications, such as quantum memories for light and nonlinear optics at the single-photon level. However, despite many spectacular demonstrations of quantum atom-light interactions, such interfaces still face two major bottlenecks. First, the error bounds for most protocols scale unfavorably with system resources. Second, it is extremely difficult to improve these figures of merit in conventional systems. Within this context, DAALI will pursue new, disruptive platforms and protocols, which offer novel solutions to boost important system parameters and/or reduce the resources needed for applications. In particular, we will: • Develop state-of-the-art interfaces between atomic media and nano/micro-photonic systems. Such systems offer excellent potential for scalability and large atom-photon coupling strengths. Moreover, the flexibility to engineer their spatial modes and dispersion enables new, powerful paradigms that have no obvious analogue in macroscopic interfaces. • Demonstrate novel protocols for quantum memories and photon-photon gates. These protocols will take advantage of novel mechanisms such as those found in nanophotonic interfaces, “selective radiance,” and strong atom-atom interactions. These novel effects can even enable error rates that scale exponentially better as a function of physical resources than previously known bounds. DAALI brings together partners with theoretical and experimental expertise in atomic physics, quantum optics, and photonics, who will work together to solve the multi-disciplinary challenges needed to design and construct real systems that can maximally utilize and exploit these disparate concepts. Our results have the potential to completely re-define the technological possibilities of light-matter interfaces.

Keywords: quantum optics,atomic physics
Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology (NanoSolveIT) (NanoSolveIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Ireland,Australia,South Africa,Germany,Germany,Cyprus,Finland,Greece,Sweden,Korea, Republic of,Greece,Norway,Finland,Poland,Netherlands,United States,United Kingdom,Denmark,United Kingdom,United Kingdom,Japan
Call: Nanoinformatics: from materials models to predictive toxicology and ecotoxicology (RIA) (H2020-NMBP-TO-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-08-31
Duration (months): 56.0
Total project cost (EUR): 7485194.5
EU funding (EUR): 6098527.5
Participants: 29
Project status: SIGNED

NanoSolveIT will introduce a ground-breaking in silico Integrated Approach to Testing and Assessment (IATA) for the environmental health and safety of Nanomaterials (NM), implemented as a decision support system packaged as a standalone open software and a Cloud platform. NanoSolveIT will develop and deliver: (i) a reliable user friendly knowledge-based infrastructure for data hosting, sharing and exploitation, (ii) NM fingerprints, sets of nanodescriptors and properties that can be predictively linked to NM functionality, exposure and hazard, thereby supporting NM grouping, safe-by-design (SbD) and regulatory risk assessment (RA), (iii) innovative methodologies for NMs predictive (eco)toxicology underpinned by artificial intelligence and state-of-the-art in silico techniques, and, (iv) integration with multi-scale modelling, RA and governance frameworks developed in EU H2020 funded and in the forthcoming NMBP-13 project(s). NanoSolveIT will deliver a validated, sustainable, multi-scale nanoinformatics IATA, tested and demonstrated at TLR6 via OECD style IATA case studies, serving the needs of diverse stakeholders at each stage of the NMs value chain, for assessment of potential adverse effects of NM on human health and the environment. NanoSolveIT is fully aligned to the objectives of the EU-US Nanoinformactics Roadmap, addressing all 13 of its short, medium and long term milestones, and supports the recommendations of the EMMC on standards for developing material modelling software and OECD best practice. The NanoSolveIT consortium (EU and international partners) is the only grouping capable of delivering the ambitious goals of the NMBP-14-2018 call, since they have collectively driven most of the current progress in nanoinformatics: 81% of the nanoinormatics papers cited in the EU-US nanoinformatics roadmap had NanoSolveIT authors. NanoSolveIT will integrate across the consortium-wide modelling approaches to provide the IATA platform for in silico NMs RA.

Keywords: nanoinformatics,iata,nanomaterial fingerprints,nanomaterial grouping,nanomaterial predictive eco toxicology,nanomaterial cloud platform,nanomaterial risk assessment
Flows of hot plasma connecting the Milky Way centre to the corona, halo and beyond (Hot Milk)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany,Italy
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2026-02-28
Duration (months): 72.0
Total project cost (EUR): 1989375.0
EU funding (EUR): 1264375.0
Participants: 2
Project status: SIGNED

We are less than one year away from the beginning of a revolution in our understanding of the hot, X-ray emitting, plasma of the Milky Way. The growth of galaxies in the local Universe critically depends on the interplay (via outflows and re-condensation) between the hot plasma with the other phases of the interstellar medium (ISM). As a prototype for typical spiral galaxies, the Milky Way offers the unique opportunity to capture the important details of such feedback all the way from sub-parsec to galactic scales. In the 90's, the ROSAT all-sky X-ray maps confirmed the existence of a hot component of the ISM, the Galactic corona. However, because of strong obscuration in the soft X-ray energy band, those maps have a limited horizon of ~1 kpc in the Galactic plane. Therefore, despite the fundamental role of the hot ISM phase, its properties are still basically unknown outside the Solar neighbourhood. My XMM surveys of the Galactic centre (GC) demonstrate that the hot ISM phase can be traced throughout the disc in the harder X-ray band, confirming the feasibility of this ERC project and the strong connection between GC activity and the Galactic corona. Additionally, the hot plasma is a plausible candidate for containing the missing Galactic baryons and a key ingredient for galaxy evolution. However, so far only less than 0.03% of the Milky Way has been covered by the narrow fields of view of current X-ray imaging telescopes. The eROSITA all-sky survey will rectify this state of affairs. Should this ERC proposal be approved, we will trace the connection and feedback between the Galactic corona and halo with the energetic activity at the GC (e.g., due to cosmic rays, stellar and AGN outflows). This will represent one to two orders of magnitude improvement in sensitivity and/or coverage, compared to current surveys. Our sensitive X-ray maps will represent an invaluable legacy for future multi-wavelength studies with current and next generation array instruments.

Keywords: x rays,galactic center,galactic corona and halo,stellar and agn feedback,outflows,interstellar medium,galaxy evolution,cosmic rays,missing baryons
Elucidating Neuronal Susceptibility to Mitochondrial Disease (NEUROMITO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Mitochondria generate most of the energy cells require to function. Deficits in the mitochondrial energy-generating machinery affect 1:5,000 children and cause progressive, debilitating, and usually fatal pathologies collectively known as primary mitochondrial disease. To date, there is no cure for mitochondrial disease and existing treatments are highly ineffective and mostly palliative. High-energy-requiring cells, such as neurons, are especially affected in mitochondrial disease. However, not all neuronal populations are equally affected. Furthermore, the molecular determinants of neuronal vulnerability to mitochondrial disease have not been adequately elucidated, representing a challenge for the development of efficient treatments for these pathologies. To improve on current knowledge on mitochondrial disease and to provide better therapeutic targets, this project focuses on developing ground-breaking mouse genetics and molecular biology tools that will allow the identification and dissection of the molecular determinants of neuronal vulnerability in mitochondrial disease with unprecedented definition. We will develop novel techniques to isolate both the mitochondrial and cytosolic translatome by using ribosomal tagging in vivo as well as to assess intact mitochondrial function with cell-type specificity and temporal resolution. These novel approaches will have a high impact in mitochondrial disease, with the overall aim of identifying novel therapeutic targets that will lead to effective treatments for mitochondrial disease. Furthermore, the high applicability of the tools generated will allow significant breakthroughs in the research of other pathologies with mitochondrial affectation such as diabetes or neurodegenerative processes.

Keywords: mitochondrial disease,encephalopathy,cell specific,in vivo,mouse genetics
Reconstructing the complete developmental lineage of Platynereis dumerilii (DeCoDe Platy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Cells in multicellular organisms show a huge diversity of shape, size, and function, yet are all descended from the same totipotent zygote. As development progresses, cells lose their ability to contribute to different fates, instead committing to a narrower subset of expression programs. This stepwise reduction of differentiation potential has been illustrated in Waddington’s epigenetic landscape (“Waddington lineage”). The specific gene expression programs of cell types are governed by Core Regulatory Complexes (CoRCs), where transcription factors cooperate to maintain their own expression and the effector genes that give rise to the cellular phenotype. Cell types exist as terminal or transitory states of the Waddington lineage, and it is yet unclear whether and to what extent transitory developmental and terminal cell types involve similar or distinct regulatory principles and effector modules. I will reconstruct the Waddington lineage of Platynereis dumerilii, an indirectly developing marine invertebrate with a wealth of transitory developmental and terminal cell types. I will gather single-cell RNA-seq and chromatin accessibility data for multiple developmental stages and computationally identify putative cell types. I will map these onto locations in the animal body using the in-situ expression patterns of lineage and cell type markers, and exploit unique electron microscopy data to explore the connection between gene expression and subcellular morphology. After connecting successive stages computationally, I will validate the resulting Waddington lineage with functional experiments, disrupting the expression of effector genes in the terminal cell types with CRISPR/Cas9. By combining gene expression, chromatin accessibility, cellular lineage information, functional genomics, spatial localization, and, uniquely, subcellular morphology, we will shed light on animal development and the regulatory mechanisms that govern cell types.
Commutators, Hilbert and Riesz transforms, Shifts, Harmonic extensions and Martingales (CHRiSHarMa)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany,France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1523963.0
EU funding (EUR): 1024526.21
Participants: 2
Project status: CLOSED

This project aims to develop two arrays of questions at the heart of harmonic analysis, probability and operator theory: Multi-parameter harmonic analysis. Through the use of wavelet methods in harmonic analysis, we plan to shed new light on characterizations for boundedness of multi-parameter versions of classical Hankel operators in a variety of settings. The classical Nehari's theorem on the disk (1957) has found an important generalization to Hilbert space valued functions, known as Page's theorem. A relevant extension of Nehari's theorem to the bi-disk had been a long standing problem, finally solved in 2000, through novel harmonic analysis methods. It's operator analog remains unknown and constitutes part of this proposal. Sharp estimates for Calderon-Zygmund operators and martingale inequalities. We make use of the interplay between objects central to Harmonic analysis, such as the Hilbert transform, and objects central to probability theory, martingales. This connection has seen many faces, such as in the UMD space classification by Bourgain and Burkholder or in the formula of Gundy-Varapoulos, that uses orthogonal martingales to model the behavior of the Hilbert transform. Martingale methods in combination with optimal control have advanced an array of questions in harmonic analysis in recent years. In this proposal we wish to continue this direction as well as exploit advances in dyadic harmonic analysis for use in questions central to probability. There is some focus on weighted estimates in a non-commutative and scalar setting, in the understanding of discretizations of classical operators, such as the Hilbert transform and their role played when acting on functions defined on discrete groups. From a martingale standpoint, jump processes come into play. Another direction is the use of numerical methods in combination with harmonic analysis achievements for martingale estimates.

Keywords: multi parameter analysis,weighted space,commutator,riesz transform,martingale,dyadic