Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A multi-dimensional feature space for predictions in the brain (PredictiveBrainSpace)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-15
End date: 2026-03-14
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

The brain uses prior experiences to make a “best guess” of the noisy and ambiguous information in the world around us. These predictions are constantly updated as new sensory information becomes available, yet the computational resources of the brain are limited. What is a viable model for representing and updating predictions in the brain that is both computationally efficient and neurobiologically plausible? I hypothesise that the brain represents predictions by decomposing them into their constituting features and pre-activating those features considered instrumental in explaining the sensory input, thereby allowing to update only parts of the prediction without revising the whole prediction. The proposed project fuses concepts of multi-dimensional feature encoding, cortical processing hierarchies and activity-silent working memory to develop a computational model of prediction and error coding using artificial neural networks. The implications of this model will be empirically tested in human visual perception using functional magnetic resonance imaging with laminar precision. This project aims to gain a deeper understanding of the compositionality of predictions as a building block of fast and accurate perception and bears the potential to transform our understanding of the neural mechanisms giving rise to predictive processes. The project will be carried out at the Donders Institute for Brain, Cognition and Behaviour in the lab of Floris de Lange, a leading expert in the field of predictive processing. As an MSCA postdoctoral fellow, I will conduct cutting-edge research at the intersection of psychology, neuroscience and artificial intelligence, which will give me the opportunity to hone my methodological and management skills, as well as develop my own research program.

Keywords: predictive processing,artificial neural networks,neural representational space,fmri
European Research Institute on Simulation (ERIS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Spain,France,Belgium
Call: Experimentation and exchange of good practices for value creation (HORIZON-WIDERA-2024-ERA-02, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 5
Project status: SIGNED

The ERIS project will address the critical need for standardised, high-quality training in cardiac electrophysiology (EP) across Europe. The project will tackle the fragmented and inconsistent training landscape that limits healthcare professionals' ability to adopt new technologies efficiently, particularly in underserved regions. With the growing prevalence of cardiac arrhythmias, such as atrial fibrillation and ventricular arrhythmias, due to an ageing population, it is vital that electrophysiologists receive thorough and cohesive training. The ERIS project proposes to create a collaborative, Europe-wide educational hub involving academia, university hospitals, scientific societies, and industry partners. By integrating theory, simulation, and practical training, this initiative ensures that healthcare professionals are well-equipped to provide innovative interventional treatments for cardiac conditions. One of the main challenges is the reliance on industry-led training courses, which, while beneficial, often lack full academic commitment, integration of the three training steps, and accessibility across different regions. Additionally, these courses can also present conflicts of interest. The ERIS project seeks to overcome these barriers by developing academic-driven training programmes that offer certification and ensure the quality, consistency, and independence of the education provided. This novel training platform will be designed with long-term sustainability in mind, creating a network of facilities across Europe. The first phase will focus on EP training, and the model will be expanded to cover other medical specialties in the future. Through this initiative, ERIS aims to reduce healthcare disparities, improve patient outcomes, and ensure that healthcare professionals are continuously trained in the latest innovations in order to provide these advancements to the EU patients.
Early Medieval English in Nineteenth-Century Europe: The Transnational Reception of Old English in the Age of Romantic Nationalism (EMERGENCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499713.0
EU funding (EUR): 1499713.0
Participants: 1
Project status: SIGNED

This project adds an essential decentralizing dynamic to the historiography of Old English studies, by studying the reception of early medieval English in 19th-century continental Europe and going beyond an Anglo-American focus. Many current linguistic theories, modes of literary criticism and editorial and pedagogical practices have their roots in the 19th century; investigating this legacy helps to better understand paradigms and institutions that still influence the field today. Recent researchers typically link 19th-century engagements with Old English to a desire to historically underpin a patriotic sense of Englishness or the perceived racial superiority of white Americans. Problematically, this Anglo-American lens overlooks an important transnational dimension: the reception of Old English in continental Europe. In the 19th century, Old English poems were claimed as cultural heritage by various non-Anglophone nations, including the Danes, the Germans and the Dutch. These competing nationalistic, cultural appropriations happened against the backdrop of a growing interest in Old English language and literature across the European continent. Exploring this transnational reception of Old English offers a new perspective on the 19th-century foundations of Old English studies and thus contributes to ongoing discussions about the field’s past, present and future in terms of diversity and visibility. This project will identify and analyse interactions with Old English across Europe to explore how a more geographically diverse genealogy of the field affects our perception of the 19th century as a foundational period for the study of Old English. The project, situated on the intersection of history of humanities and medievalism studies, is powered by a bibliographical and relational database and a multi-disciplinary, multilingual approach. It will reveal new, insightful materials, uncover intellectual networks and put forgotten protagonists in the limelight.

Keywords: medievalism old english language and literature beowulf history of medieval studies
SOlutions TEsting for Regions through Insurance for climate Adaptation (SOTERIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Spain,Norway,Germany,Greece,Bulgaria,France,Switzerland,Croatia
Call: Best practices on and piloting insurance solutions for climate adaptation in EU regions and communities (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 2998353.75
EU funding (EUR): 2998353.75
Participants: 33
Project status: SIGNED

The SOTERIA project aims to advance innovative insurance solutions for climate change adaptation in different European regions and communities. To do so, SOTERIA will work through three main tracks forming the core of our approach: i) documenting best practice in relation to data, new insurance and robust enabling frameworks; ii) testing of some of these solutions; and iii) the creation of communities of practice for regions and insurance as legacy. We aim to help reducing the protection gap by documenting best practice and the testing of insurance products and services that reward proactive prevention measures while seeking to increase coverage through co-designed solutions. We will also consider the enabling framework that analyses the role of public sector modernisation and how to develop affordable insurance schemes that leave no one behind, through our Communities of Practice engaged in Climate Resilience society-insurance dialogues. SOTERIA will take these solutions from the levels of research to demonstration and testing with some at the level of pre-commercial procurement in at least three cases thanks to a network of three pilots and 5 satellites that span different geographical areas (and needs). The project legacy a set of best practice materials as well as a Community of Practice to support other regions interested to design and/or adopt innovative insurance solutions. SOTERIA will contribute to the wider goal of the Mission Adaptation to increase Europe’s resilience and preparedness to face unavoidable consequences of climate change by filling the gaps on insurance coverage for climate adaptation.

Keywords: best practice testing innovative insurance solutions,enabling framework
Breast Milk Biomimetic Nano Particles as a Versatile, Non-Invasive, Oral Drug Delivery Tool (MILKOSOMES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2437500.0
EU funding (EUR): 2437500.0
Participants: 1
Project status: SIGNED

We propose to use human breast milk cells to engineer breast milk biomimetic nanoparticles (NP), “MILKOSOMES,” to shuttle medicines orally into the body that, under other conditions, would not be able to distribute properly. MILKOSOMES are cellular membrane protein-functionalized phospho-lipid NP (i.e., liposomes), and they are hypothesized to cross the gastrointestinal (GI) tract while protecting their therapeutic cargo and serve as a novel way to improve oral therapy outcomes. Unfortunately, although oral delivery of therapeutic agents is the most patient-preferred route of administration because it is painless and convenient, it entails enormous challenges. Specifically, large molecules, such as messenger RNA and proteins, cannot be delivered orally due to their chemical and enzymatic degradation in the GI tract and poor intestine's permeability to these molecules. Interestingly, cells, which are a thousand times bigger than these large molecules, remain intact. Therefore, they can get out of the GI tract due to membrane protein-mediated biological processes and make their way into our bodies. Herein, we aim to: (1) Identify and assess the breast milk cell populations which cross the GI tract into the infant body after breastfeeding in vivo, (2) Fabricate and characterize MILKOSOMES, (3) Evaluate MILKOSOMES’ ability to cross the GI tract biological barrier using in vitro and ex-human models, and (4) Test MILKOSOMES’ therapeutic efficacy in vivo using two diverse in vivo models. Thus, we will harness the specific and unique biological function of these GI tract-crossing native cells while protecting their therapeutic cargo from degradation using the phospho-lipid NP backbone. Our findings will increase our fundamental understanding of cellular and NP trafficking through the GI tract and lay the foundations for designing a next generation and non-invasive nano-biomimetic oral drug delivery technology that may affect public health worldwide.

Keywords: biomimicry liposomes drug delivery
Earthquake Energy Radiation Across Spectrum: a multidisciplinary study (ERASMUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Destructions left after an earthquake are mostly caused by high-frequency ground motion that originates from the seismic source. I will exploit the natural continuity between geodetic and seismological data to illuminate high-frequency sources and their relations with changes in earthquake rupture speed. I propose an innovative Bayesian 2-step kinematic inversion in the frequency domain to investigate these destructive and poorly constrained high-frequency sources. This probabilistic approach is based on near-field data and a detailed analysis of the model parameter uncertainties, which allows better locating the HF sources. The project will bring new insights into how high-frequency relates to tectonic features, both in subduction zones and large continental faults. ERASMUS will be a collaborative effort between different earthquake-related communities to generate knowledge that can be included in more reliable seismic hazard assessment, impacting society significantly.

Keywords: seismogeodesy,earthquake hazard assessment,high frequency radiation,seismotectonics,geodesy gnss and insar,seismology kinematic inversion,strong motions
On-Board Monitoring of In-Service Trains for the Structural Health Monitoring of Railway Bridges (OMoRail)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 297164.16
EU funding (EUR): 297164.16
Participants: 2
Project status: SIGNED

Railway systems are expanding rapidly worldwide as a 'green' means of transportation. Such rapid expansion poses a challenge to guaranteeing safety and ensuring the quality of railway systems. Continuous monitoring of tracks and rail bridges can help diagnose and prognose damage timely, increasing railway transportation reliability. In this project, we focus on rail bridges, whose condition assessment traditionally relies on a static network of sensors. Although well-established, this technique lacks portability, entails considerable cost and effort, and, crucially, inhibits continuous monitoring, as the lifespan of sensors is generally smaller than that of the bridge. To tackle these limitations, indirect monitoring practices have recently gained attraction. Such methods extract the dynamic properties of bridges via measurements from traversing vehicles by exploiting the Vehicle-Bridge Interaction (VBI) principle. This way they offer mobility and lower installation and maintenance costs. However, the majority of studies on indirect monitoring of bridges focus on highways. Despite the similarities of VBI modelling between highways and railways, distinct differences (e.g., vehicle and contact models, moving speed, loading patterns) do not allow the direct application of current indirect monitoring methods to railway bridges. Another challenge is the blurring effect of surface roughness, which, simplistically, is typically considered as known or is eliminated. To this end, this project proposes a consistent methodology to continuously monitor railway bridges via On-Board Monitoring of in-service trains, with a simultaneous characterization of the involved roughness profiles. Accordingly, it proposes a hybrid modelling procedure that considers a VBI model (which represents actual train-bridge systems and considers the roughness of the involved track system) fused with vibration measurements collected from traversing trains.

Keywords: structural health monitoring shm railway bridges rail irregularities vehicle bridge interaction vbi on board monitoring obm
Tracing Indigenous American genomic history, subsistence strategies, health and their interplay through time using DNA from ancient masticated plant fibres (QUIDS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1491174.0
EU funding (EUR): 1491174.0
Participants: 1
Project status: SIGNED

Palaeogenomics has revolutionised our understanding of human population history at the biological and sociocultural level by analysing thousands of ancient human genomes sequenced from skeletal remains. Unfortunately, this approach requires destructive sampling of the skeletal remains, and thus can often be in conflict with the values of descendant communities and national heritage conservation policies. Although alternative sources of ancient human DNA have been sought, their utilisation requires prohibitive sequencing data volumes, or they are rare in the archaeological record, thus precluding large-scale studies. To circumvent these limitations, we will use a novel DNA source: ancient quids. Quids are wads of masticated plant fibres recovered from archaeological sites. Analogous to a buccal swab, an ancient quid contains traces of the chewer's, their oral microbiome's and the chewer's meals' DNA, as well as that of the plants used for its elaboration. Therefore, quid DNA can be used to simultaneously track human population history, dietary and microbiome shifts, pathogen prevalence and their interplay through time. We will use quid DNA to reconstruct the evolutionary history of the Indigenous peoples from the Americas, a continent where human evolutionary history is understudied, skeletal remains are rare, and the destructive sampling of such remains is often limited. In contrast to skeletal remains, quids are abundant in the American archaeological record and span from the Late Pleistocene to the Holocene and recent centuries. Through ancient quid DNA, we will reconstruct the genomic history of Indigenous Americans, their past lifeways and subsistence strategies, their health, and how these influenced each other throughout the three major historical transitions in the continent: the initial rapid peopling by hunter-gatherers, the emergence of complex agricultural societies and their demise during European colonisation.

Keywords: ancient dna palaeogenomics human population genetics cultural evolution peopling of the americas
Nanoscale virus imaging X-ray microscope based on incoherent diffraction (NanoXCAN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal,France,Germany,Czechia,Switzerland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-05-01
End date: 2026-04-30
Duration (months): 48.0
Total project cost (EUR): 3723551.0
EU funding (EUR): 3723551.0
Participants: 7
Project status: SIGNED

Coronavirus disease (COVID-19) is an infectious disease that emerged in late 2019. By March 2020, the outbreak was declared a devastating pandemic and clearly illustrated the threat that viruses pose to our society. The characterization of viral structures and the identification of key proteins involved in each step of the cycle of infection are crucial to developing treatments. Yet imaging single viruses can only be performed in a few specialized centers in Europe, while every hospital could benefit from it. NanoXCAN proposes to develop a tabletop virus imaging X-ray microscope, with foreseeable impact as revolutionary as the invention of super-resolved fluorescence microscopy, paving the way towards determination of structure and dynamics of matter to a large community. For this purpose, we will develop an original digital laser that delivers, on a daily operation, subwavelength focusing, reaching relativistic intensities at MHz repetition rates. This will be used to create a nano-source of hard X-rays from the Kalpha plasma emission of metallic nano-targets at an average power comparable to that of a synchrotron beamline. We will capitalize on this high brilliance, high average power hard X-ray source to perform lensless nanoscale biomedical imaging based on recent findings in incoherent imaging and machine learning. All these ingredients will create a unique nanoscopy platform that our consortium will illustrate by imaging a single virus. In the future, our X-ray IDI microscope could help to study mechanisms involved in viral infection and antiviral design. X-rays have the advantage of performing in-situ non-destructive and non-invasive imaging over competing techniques. NanoXCAN will create a transformative positive effect on our economy and society by proposing this new technology for single virus imaging.

Keywords: femtosecond nanoscale fiber laser x ray lensless imaging sub wavelength relativistic intensity single cell