Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Depicting the impact of an invasive alien crop pest on local ecological networks (PESTNET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 255768.0
EU funding (EUR): 255768.0
Participants: 2
Project status: SIGNED

Invasive alien herbivore species are a major threat to agriculture because they directly damage crops and induce severe yield losses, but also because they indirectly impact the structure, stability and functioning of native arthropod communities. Indirect facilitation mechanisms can cause unpredictable outbreaks of native pest species but, surprisingly, they have been rarely studied within arthropod communities. Within the framework of invasive species management (Regulation EU 1143/2014), understanding pest facilitation mechanisms is a research priority. This is also because invasive species negatively impact the reliability of agricultural Decision Support Systems, used in sustainable agriculture (Directive 2009/128/EC). PESTNET aims, as general objective, at developing a novel inter- multidisciplinary and intersectoral approach (field monitoring, DNA metabarcoding, multilayer ecological network analyses, citizen science) to depict the basic and applied ecological consequences of a human-introduced alien crop pest on the invaded trophic network. The model system used for implementation is represented by the highly invasive Brown Marmorated Stink Bug, Halyomorpha halys, native stink bug species and shared egg parasitoids. An original two-fold cutting-edge approach is proposed aiming at assessing the following specific objectives: Obj. 1) Evaluation of indirect pest facilitation mediated by host-parasitoid prevalence in non-invaded vs. invaded networks; Obj. 2) Evaluation of stink bug community changes using a mobile monitoring system (app) to estimate spatial trends in stink bugs abundance. Through the involvement of academic and non academic (industry) partners, the project will provide novel insights on how an invasive herbivore pest of worldwide economic importance is impacting sustainable agriculture by interference with the local arthropod community.

Keywords: halyomorpha halys,egg parasitoids,trophic interactions,dna based detection of trophic interactions,invasive alien species,citizen science
Calcium and magnesium metal anode based batteries (CAMBAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1688705.0
EU funding (EUR): 1688705.0
Participants: 1
Project status: CLOSED

Li-ion battery is ubiquitous and has emerged as the major contender to power electric vehicles, yet Li-ion is slowly but surely reaching its limits and controversial debates on lithium supply cannot be ignored. New sustainable battery chemistries must be developed and the most appealing alternatives are to use Ca or Mg metal anodes which would bring a breakthrough in terms of energy density relying on much more abundant elements. Since Mg and Ca do not appear to be plagued by dendrite formation like Li, metal anodes could thus safely be used. While standard electrolytes forming stable passivation layers at the electrode/electrolyte interfaces enabled the success of the Li-ion technology, the migration of divalent cations through a passivation layer was thought to be impossible. Thus, all research efforts to date have been devoted to the formulation of electrolytes that do not form such layer. This approach comes with complex electrolyte, highly corrosive and with narrow electrochemical stability window leading to incompatibility with high voltage cathodes thus penalizing energy density. The applicant demonstrated that calcium can be reversibly plated and stripped through a stable passivation layer when transport properties within the electrolyte are tuned (decreasing ion pair formation). CAMBAT aims at developing new electrolytes forming stable passivation layers and allowing the migration of Ca2+ and Mg2+. Such a dramatic shift in the methodology would allow considering a completely new family of electrolytes enabling the evaluation of high voltage cathode materials that cannot be tested in the electrolytes available nowadays. 1Ah prototype cells will be assembled as proof of concept, targets for energy density and cost being ca. 300 Wh/kg and 250 $/kWh, respectively, thus doubling the energy density while dividing by at least a factor of 2 the price when compared to state of the art Li-ion batteries and having the potential for being SAFER (absence of dendrite).

Keywords: battery,divalent cations,electrolyte
The structure and molecular mechanism of transport proteins within the PACE family of multidrug efflux pumps (PACEMech)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-09
End date: 2019-01-08
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Antimicrobial resistance is recognised as one of the greatest threats to human health worldwide. Multidrug efflux pumps play a major role in the development of drug resistance in bacterial pathogens. These pumps are able to actively export remarkably broad collections antibiotics and biocides out of the cell. Multidrug efflux pumps have classically been organised into five distinct families or superfamilies. Due to their importance, representative proteins from each of these families have been extensively studied. Using a combination of functional genomics and biochemical methods to study antimicrobial resistance in the hospital pathogen Acinetobacter baumannii, I recently identified AceI, the founding member of a sixth family of multidrug efflux pumps called the Proteobacterial Antimicrobial Compound Efflux (PACE) family. The PACE family is the first new family of efflux pumps to be described in 15 years. In light of its recent identification, there is a paucity of fundamental data describing how PACE family pumps mediate drug efflux. This proposal will apply in vitro biochemical, biophysical and structural analyses to reveal molecular details of the structure and functional transport mechanism operating in PACE family pumps. This proposal will draw on the diverse collective expertise of my Fellowship Supervisor Prof Peter Henderson and his expert colleagues in membrane protein structural analyses and biophysics. In conducting this research I will build lasting collaborative links with these experts that will extend beyond the duration of this fellowship. I will receive specialised training in powerful membrane protein analysis methods that are essential to my career goal of establishing a leading research laboratory examining membrane transport proteins, from regulation to molecular mechanisms. My laboratory vision is to develop novel strategies to interfere with drug efflux pump function and so overcome resistance conferred by this important class of proteins.

Keywords: antimicrobial resistance,multidrug efflux,membrane transport
Multifocal structured illumination optoacoustic microscopy (MSIOAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 171460.81
EU funding (EUR): 171460.8
Participants: 2
Project status: CLOSED

Optoacoustic imaging is a highly scalable and versatile method that can be used for optical resolution microscopy (OR-OAM) at superficial depth yet can be adapted for tomographic imaging with ultrasonic resolution at centimeter penetration scale. However, the imaging speed of OR-OAM is slow as far as concerned with acquisition of volumetric data, which greatly restricts its usage in applications involving dynamic biological processes. In this MSCA project, we propose to develop a new approach using multifocal structured illumination in conjunction with a spherical ultrasonic array detection to achieve real-time volumetric optoacoustic imaging in both optical and acoustic resolution modes. Several challenges are to be addressed to reach these objectives. Firstly, a multifocal structured illumination system with two identical beamsplitting gratings will be designed and fabricated. Secondly, optoacoustic signal unmixing method for the spherical ultrasonic array detection geometry will be developed and image reconstruction algorithms based on the unmixed signals devised. Thirdly, calibration methods for the proposed system will be investigated. Finally, real-time volumetric optoacoustic imaging will be demonstrated in living animals With the proposed method, real-time volumetric imaging at multiple penetration scales can be accomplished, making it possible to study dynamic functional, kinetic and metabolism parameters at the cellular, organ and whole organism level. By opening new possibilities for visualization of multi-scale dynamics not attainable with existing imaging modalities, the new method will broadly affect both pre-clinical and clinical imaging in the fields of in vivo cell tracking, targeted molecular imaging, studies of tumor dynamics and neovascularization, functional brain imaging.

Keywords: optoacoustic imaging,photoacoustic imaging,optoacoustic tomography,multifocal structured illumination,optical resolution optoacoustic microscopy
MAnufacturing of TUmour-REactive Natural Killer cells (MATURE-NK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Spain,Israel,Germany,Germany,Italy,Germany,Switzerland,Norway,France,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 3347488.66
EU funding (EUR): 3347488.66
Participants: 14
Project status: CLOSED

This project will provide future-oriented translational research training designed to bridge the gap between basic research and applied development of new cell-based therapeutic products by the biotech industry and their clinical use for incurable diseases. This will be done on the example of activated/genetically manipulated natural killer (NK) cells, which are classified as Advanced Therapy Medicinal Products ("ATMPs"), and their use in treatment of cancer refractory to classical therapies. For this we combine experts in NK cell biology supported by bioinformatics, clinical groups pioneering NK cell therapies and biotech companies with NK cell-based portfolios. A student exchange will ensure training in basic, clinical and private sectors. Network-wide training modules organized in summer/winter schools include immunotechnology, business management and intellectual property rights. This will train competences important to translate research findings to personalized medicine. In research we build on information from clinical trials of NK cell-based therapies. We will improve anti-tumor reactivity of NK cells including selection of NK subsets and modulation of NK receptor/ligand interactions. First, this will comprise i) improved donor/recipient combination and NK subsets and ii) modification of NK cells by chimeric antigen receptors ("CAR") and bispecifc antibody reagents to cross-link NK cells to tumor targets. Second, it will fortify NK cell reactivity by i) blocking ligand interactions of inhibitory receptors ("checkpoint inhibitors") and ii) defining unknown ligands of activating NK receptors on tumor cells. Third, procedures and NK products in their best combination will be developed by i) evaluation in humanized mouse models, ii) building a GMP-compliant manufacturing process and iii) design of a clinical trial protocol. The project should provide for manufacturing of NK cell-based therapeutic products and their evaluation in clinical trials.

Keywords: nk cells,immunotherapy,therapeutic cell manufacturing,chimeric antigen receptors cars,antibody therapeutics,cancer,leukemia,advanced therapy medicinal products atmps,gmp manufacturing
The lure of the foreign stage: Italian art and artistry serving the French and European spectacle. (SPECTACLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

The proposed research is a multidisciplinary investigation on the role of spectacle during the radical transformation of European politics and culture in the decades between 1780 and 1820. Its principal aim is to define the cultural meaning of ‘spectacle’ and ‘spectacularity’ in eighteenth-century France. This will be achieved via an exploration of key contributions of Italian artists from different backgrounds and expertise (the designer Ignazio Degotti, the fireworks technicians in the Ruggieri family, and the circus performer Antonio Franconi and his family) to French and a wider European spectacle broadly conceived (e.g. theatre settings, public and private performances, propaganda events). Historians have examined cultural phenomena including theatre, visual arts, music, and popular manifestations as part of a more refined understanding of the pre-Revolutionary and Revolutionary process. However, the world of stage creation and popular festivals was inherently contingent, transient, and ephemeral. Due to this, artists and designers have not been given the same critical attention paid to musicians, dramatists, or visual artists. My research will cover this gap of knowledge in a growing body of scholarship which is only now beginning to address historical theatre production. Rather than reducing the purveyors of stage design to the ‘background’ of theatre and cultural history in their own ‘micro history,’ the novelty of my approach comes from integrating décor into cultural histories of seeing, experiencing, and remaking the world. By chronologically and biographically assembling visual and historical archival sources (sketches, wills, letters, contracts, private networks) scattered in diverse cultural institutions, the study will bring to the foreground material aspects of the spectacle-creative process and illuminate the interweaving lives of these artists, finally affording a deeper understanding of ‘spectacularity’ in European eighteenth-century culture.

Keywords: eighteenth century,stage design,artistic networks,cultural history,theatre,performances,artistry,french revolution,napoleonic empire,italian artists,french artists,fireworks,circus
PATHWAYS TO INCLUSIVE LABOUR MARKETS (PILLARS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Estonia,Germany,China,France,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Technological transformations, skills and globalization - future challenges for shared prosperity (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2994973.75
EU funding (EUR): 2994973.75
Participants: 11
Project status: SIGNED

PILLARS offers a three-pillars framework that includes: (1) A comprehensive and empirically solid account of the combined effect of (i) past waves of automation technologies, (ii) recent trends of international fragmentation of production in Global Value Chains (GVCs) and (iii) industrial transformation of European regions on EU labour markets, in terms of employment reconfiguration, skill mismatch and migration. (2) A comprehensive set of forecasting scenarios based on the impact assessment in (1) and projection of (i) industries’ future exposure to emerging automation technologies; (ii) EU regional industrial transformation and (de)specialisation; and (iii) functional reallocation of workers along GVC and migration flows; and (iv) potential skill mismatch resulting from projections of skill demand and supply. (3) A systematic evaluation of current labour market policies, based on smart specialisation, and training policies that allows identifying areas of success and directions to be mitigated. This will lead to proposing a coherent and cohesive policy roadmap that includes a battery of action in different policy areas (innovation, trade, education and training) to achieve Pathways to Inclusive Labour Markets. PILLARS’ ambition to contribute to assess current labour market policies and co-design a new generation of policies for the future of work will be fulfilled by a consortium of top scholars, including partners from Latin America and China; an enthusiastic, international, multidisciplinary stakeholder support to the potential of PILLARS; and a top notch academic advisory board.

Keywords: inclusive policies,economics of innovation,globalisation and global value chains,industrial dynamics,skills,labour demand and supply,inequality,migration,regional diversification,future studies
Circulation Pilot with Continuous Control of Multi-Modal Air Cargo Containers (CITRIMACC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands,Netherlands,United Kingdom,Luxembourg
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 3412665.0
EU funding (EUR): 2388864.75
Participants: 4
Project status: CLOSED

Air cargo transportation system is designed to provide fast and efficient shipment of goods, two features that make it highly vulnerable to potential security threats. The main objective of the project is to implement and validate in real-life environments a system that addresses these security risks and is aligned with the time and cost realities of the air cargo industry so it does not interfere with the trade flow. The project concept is a smart and secure cargo container and information exchange platform that can reduce screening costs and eliminate tampering risks by combining advanced composite materials, secure PIN-code lock, electronic shipping documents (e-freight), web-based software for data storage and a 24/7 fully redundant communication systems based on GPS, GPRS and RFID technology for continuous real-time visibility. The project will select of participants in the entire value chain (shippers, logistics services providers, handling agents, airlines, customs, forwarders and consignees), and select two closed-loop transport lanes to execute the pilot. The consortium assembles 4 research performing SMEs with unique and complementary expertise, who will produce together a pre-series of 250 containers, obtain the relevant approvals from FAA/EASA, and deploy the solution with the pilot customers. The project results, as compared with the current packaging, transport and security management methods, will be widely disseminated via industry associations such as IATA, TSA and TIACA. A full industrialization and commercialization plan will be developed in the course of the project.

Keywords: secure container,freight,air cargo
Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS) (APTALAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-20
End date: 2017-07-19
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques. The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020. The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.

Keywords: light addressable potentiometric sensors,aptamer,mesenchymal stem cell,cell surface interactions