Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Immunome project consortium for AutoInflammatory Disorders (ImmunAID)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Switzerland,Switzerland,Türkiye,Belgium,Belgium,Greece,Slovenia,Belgium,Greece,France,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,Luxembourg
Call: Diagnostic characterisation of rare diseases (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-05-01
End date: 2024-10-31
Duration (months): 78.0
Total project cost (EUR): 15835851.25
EU funding (EUR): 15835851.25
Participants: 27
Project status: SIGNED

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

Keywords: rare disease,immune mediated inflammatory disease,child adult transition,multidisciplinarity,inflammasome,inflammation resolution,microbiome,multiomics data integration,machine learling
Ribosome Processivity and Co-translational Protein Folding (RIBOFOLD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2482600.0
EU funding (EUR): 2482600.0
Participants: 1
Project status: SIGNED

Protein domains start to fold co-translationally while they are being synthesized on the ribosome. Co-translational folding starts in the confined space of the ribosomal polypeptide exit tunnel and is modulated by the speed of translation. Although defects in protein folding cause many human diseases, the mechanisms of co-translational folding and the link between the speed of translation and the quality of protein folding is poorly understood. Here I propose to study when, where and how proteins emerging from the ribosome start to fold, how the ribosome and auxiliary proteins bound at the polypeptide exit affect nascent peptide folding, what causes ribosome pausing during translation, and how pausing affects nascent peptide folding. Our recent results (Holtkamp et al., Science 2015; Buhr et al., Mol Cell 2016) provide the proof of principle for monitoring translation and protein folding simultaneously at high temporal resolution. First, we will follow translation processivity and folding trajectories for proteins of different domain structure types using time-resolved ensemble kinetics and single-molecule setups. The structures of complexes with stalled folding intermediates will be solved by cryo-electron microscopy. Second, we will investigate the effects of the chaperone trigger factor, the signal recognition particle, and other protein biogenesis factors on the folding landscape. Third, we will analyze transient ribosome pauses in vivo (based on ribosome profiling data) and in vitro (based on time-resolved translation assays and mathematical modeling) and identify the events that cause pausing. Finally, we will probe how changes in translational processivity affect the conformational landscape of a protein. We expect that these results will open new horizons in understanding co-translational protein folding and will help to understand the molecular basis of many diseases.

Keywords: co translational protein folding
Feasibility of an INnovative, Efficient, Solid State Energy saving system (FINESSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall project objective is to successfully develop and to scale up for market readiness, a sophisticated voltage optimisation system that can reduce electrical energy consumption by up to 20%. The EU consume 3,361.69 TWh of electricity p.a and that is growing, as is our reliance on imported energy. EU supply standard EN 50160 has been harmonised at a single phase line voltage of 230Vac ±10%, Consequently actual voltages differ significantly across Europe with from 220Vac, through 230 to 240Vac, with peak mean voltages up to 253Vac. Whilst initially perceived as a UK issue, there are in fact 11 EEA countries which have an upper limit of 230V +10%, and another 13 to follow. The Business Opportunity is that virtually all European electrical equipment is designed to operate most efficiently at 220Vac. This ‘over voltage’ leads to inefficiency and losses, (heat, eddy currents, magnetic hysteresis), increased energy bills, increased maintenance, down-time and reduced equipment life. These problems can be solved by reducing and stabilising the line voltage at the point of use, results in energy savings up to 20% if the input line voltage is 253V (230V+10%), thus representing a significant opportunity to reduce electricity bills. As we will demonstrate in section 1.4, conventional solutions and the current state of the art, do not fully solve this problem and have a number of limitations. There is therefore an urgent, unmet need for a system to reliably optimise electrical energy savings and provide a rapid return on investment for the customer. Our breakthrough solution is novel, patent protected and tested at lab scale. We initially require help to undertake a feasibility study to elaborate and de-risk our business plan. If successful we will unlock a market opportunity of €70m, create 70 jobs, reduce energy costs by €228m and CO2 by 272,270 tonnes 5 yrs post project. Ultimately helping Europe achieve demanding 2020 targets.

Keywords: voltage stabilizer,voltage optimization,buck,boost,solid state voltage stabilizer,energy usage reduction,electricity usage reduction,energy efficiency,carbon reduction,payback
Biohybrid Synapses for Interactive Neuronal Networks (BRAIN-ACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany,Italy
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1859062.0
EU funding (EUR): 1166649.5
Participants: 3
Project status: SIGNED

BRAIN-ACT aims to develop the next generation of interactive biohybrid devices which will couple biological neuronal networks to organic artificial neurons. For the first time, neurons will interact with the device by active mechanical reshaping which will transduce in the maintenance of the electrical network connection strength (long term potentiation –LTP). This will be achieved by a) processing dynamic electroactive materials b) engineering the neuromorphic abiotic surface with biological synaptic receptors and c) intergrate an in vitro biohybrid synapses array to investigate the interplay at the interface between neuronal cells and their synaptic activity with dynamic electrically-smart materials. BRAIN-ACT will pave the way for a new class of chip-based smart bioelectronic devices which will ‘have a shape of a neuron and act like a neuron’. Over 10 million people are affected by neurodegenerative diseases like Parkinson’s and Alzheimer’s worldwide and show significant loss of functionalities in their daily life. Those are mainly related to faulty connections within the brain which reflects neuronal miscommunication regulated by billions of individual connections among pairs called synapses. The ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity is called synaptic plasticity and is regulated through electrical and biomechanical signals exchanged by neurons pairs. In vitro bioelectronic platforms have been devoted to monitor and stimulate those signals across neuronal network areas to characterize electrical activity and connectivity in a passive manner. BRAIN-ACT will revolutionize the study of in vitro neuronal networks through active mechanical reshaping to establish optimal electrical signal exchange among neuronal cells. More broadly, the proposed project will define the fundamental conditions to unleash the potential of neuromorphic devices as implantable materials in to the brain.

Keywords: biomaterials,organic neuromorphic devices,neuron material interface,in vitro neuronal networks,bioelectronics
Dual Co/Photoredox Catalysis for the Synthesis of Fluorine-Containing Skipped Dienes Featuring a Quaternary Carbon Stereocenter (FUSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-15
End date: 2024-06-14
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Fluorine-containing functional groups have become of crucial importance for medicinal and agrochemical applications. The incorporation of these moieties into molecular structures allows for significant opportunities to take advantage of bioisosterism as well as to fine-tune the chemical or pharmacological properties of a desired molecule. The objective of the FUSE project is to pioneer a novel approach for the preparation of fluorinated and chiral skipped dienes bearing a quaternary carbon stereocenter. Developing methodologies for these elusive compounds allows for a wide range of synthetic post-transformations and they thus serve as valuable building blocks in synthetic chemistry and pharmaceutical development programs. The project will expand the chemical space of hydrofluoroolefins (HFOs) and utilize these fourth-generation refrigerants as readily available and inexpensive starting materials. To achieve the challenging targets, a mild, visible-light photoredox based dual catalytic approach is utilized using earth-abundant (cobalt) first-row transitional metal catalysis. As such, the replacement of the typically hazardous metal reagents utilized in the state of the art and minimizing chemical waste is forecasted. The proposed programme will be carried out in close cooperation with an industrial partner in order to provide a new flow strategy for constructing these skipped fluorodiene scaffolds. This ambitious and innovative project will contribute to propagate the sustainability and reinforce the application potential of HFOs for academic and industrial applications. The project merges multidisciplinary aspects with intersectorial knowledge transfer, enabling the transition to more sustainable development in the fine chemical and pharmaceutical sector.

Keywords: chirality,fluorinated olefins,defluorination,medicinal chemistry,bioisosterism,earth abundant metal catalysis,sustainable development,reaction mechanism,high throughput experimentation
Grassroot Wavelengths: Highly Networked Grassroots Community Radio through a scalable digital platform (GrassrootWavelengths)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Ireland,Romania,Belgium,Portugal,United Kingdom
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 2200604.67
EU funding (EUR): 1997317.25
Participants: 11
Project status: CLOSED

The Grassroot Wavelengths project will create a game changing network of inclusive digital platforms for citizen engagement, community deliberation, and the free flow of information within, into, and out of discrete geographic communities by piloting solutions for connected, inexpensive, community owned and operated radio across Europe. Our approach includes features of the Living Lab and Participatory Design methods for setting up stations and services and understanding the processes in which they will be used and appropriated, along with an emphasis on synthetic speech to support the curation of audio content, thus turning data into media. Building on the success of the existing RootIO platform – with its proven commons-oriented technology and catalytic capacities for promoting/enabling collective awareness and action, participatory innovation, community resilience, and media pluralism – we will: 1) deploy and test a network of low-power community radio stations in Ireland, Portugal, and Romania; 2) work with community groups, journalists, and public good experts to develop a robust platform for expansion across Europe; 3) enhance use and accessibility of networked community radio through text-to-speech, community oriented programming applications, and other community-supported modes for contributing and managing content); and 4) work within the EU framework to establish a public support infrastructure for local ownership and revenue generation. Together, these four actions combine to form a robust and tested platform with a clear path to scaling and exploitation in Europe and beyond.
From Tissues to Single Molecules: High Content in Situ Super-Resolution imaging with DNA-PAINT (MolMap)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-03-31
Duration (months): 72.0
Total project cost (EUR): 1695000.0
EU funding (EUR): 1310000.0
Participants: 2
Project status: CLOSED

Fluorescence microscopy is a powerful tool for exploring biomolecules in cells and tissues, especially with the advent of super-resolution techniques. To better understand key processes such as cell differentiation and disease progression, it is crucial to investigate the abundance, localization and mutual interactions of crucial cellular components such as nucleic acids and proteins. Unraveling their complex interplay in whole signaling networks is necessary to investigate cellular responses to stimuli. However, currently available characterization techniques are either limited by low multiplexing capability (e.g. fluorescence microscopy) or lack localization information (e.g. mass spectrometry). Despite the immense biological and clinical relevance of understanding network-wide changes, the lack of a technological platform to image, identify and quantify a multitude of key protein networks at high spatial resolution in tissues impedes our understanding of the molecular basis of health and disease. I aim to solve this pressing issue and revolutionize fluorescence microscopy using tools from DNA Nanotechnology with transformative potential to positively answer the question: Can we localize and identify each protein or nucleic acid molecule in a complex tissue microenvironment? The approach is based on my recently developed DNA- and Exchange-PAINT techniques. To push the envelope of what’s technically possible I will first build a lattice light-sheet microscope for deep tissue high throughput DNA-PAINT imaging. Second, I will develop novel nanobody- and aptamer-based labeling approaches in combination with molecular barcoding and automated multiplexed image acquisition and processing. With these disruptive and transformative tools, I will investigate whole signaling cascades at once in single cells and whole tissues, thus enabling quantitative imaging transcriptomics and proteomics with highest spatial resolution.

Keywords: super resolution microscopy,single molecule imaging,dna nanotechnology,quantitative microscopy
Keeping insects out of the greenhouse gate with odor-masking natural extracts (GATEKEEPER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Israel
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Insects are said to be responsible for destroying 20% of the world's crop production annually. In a closed chamber like a greenhouse, where crops are clustered in a confined area to avoid the entrance of pests, if this security perimeter is trespassed pests bloom inside without control given the mild environmental conditions and the lack of competing species. Insects are said to be responsible for destroying 20% of the world's crop production annually. In a closed chamber like a greenhouse, where crops are clustered in a confined area to avoid the entrance of pests, if this security perimeter is trespassed pests bloom inside without control given the mild environmental conditions and the lack of competing species. At EdenShield Ltd we have been producing plant extracts for the last 5 years with outstanding results. We realized that it is simpler and more respectful with the environment to avoid the first fight with insects by keeping them out of the gate of the greenhouse, than to use chemicals and biochemical to win the whole war against them once they are inside. Gatekeeper is based on a natural extract from medicinal desert plants able to camouflage the insect-attractive plant scents, achieving a proven decrease of 90% insect damages on crops at 10% of the cost of alternatives (1,560€/ha/year instead of current 15,000€/ha/year). GateKeeper is sprayed during 8 min/day at the greenhouse entrances by a simple system of sprinklers, so the active extract do not contact plants. By means of this simple but effective mechanism never used before in agriculture, we have overc GateKeeper end-users are greenhouse growers, particularly those with at least 3000 m2 per entrance, which constitute an available market in the middle term of 400,000-500,000 greenhouse entrances mainly in Europe. With a market share of 2.7% (2019), 3.9% (2020), and 5.5% (2021), we expect to sell 15,000 systems by 2021, with a €26.3 M revenue (€16.7 M profit), and increasing workforce in 9-12 people.

Keywords: insect,pest,pesticide,biopesticide,phytosanitary,plant protection,greenhouse,crop,extract,thrips,tuta revoluta,tomato,pepper,basil
The role of non coding RNA in organismal ageing (RNAging)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-03-01
End date: 2018-08-31
Duration (months): 18.0
Total project cost (EUR): 149950.0
EU funding (EUR): 149950.0
Participants: 2
Project status: CLOSED

The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cells and in vivo in animal models.

Keywords: 1 ageing,2 telomeres,3 non coding rna,4 dna damage response,5 infertility,6 tissue atrophy,7 pulmonary fibrosis