Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scientific-Based Exposure and Risk Assessment of Radiofrequency and mm-Wave Systems from children to elderly (5G and Beyond) (SEAWave)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Germany,France,Switzerland,Slovenia,Belgium,Serbia,Korea, Republic of
Call: Exposure to electromagnetic fields (EMF) and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 7317782.0
EU funding (EUR): 7317777.0
Participants: 17
Project status: SIGNED

The pervasiveness and social-economic dependence on wireless technology has steadily increased over the last three decades. Currently, the 5th generation (5G) New Radio (NR) cellular system is being deployed to unlock the potential of new applications that require the connection of many more devices (Internet of Things), higher data rates and low latency (autonomous driving, 'Factory of the Future'). 5G operates in two frequency bands, 5G NR FR1 and 5G NR FR2. Many exposure parameters of 5G are similar to those of 2G-4G. However, there are also many differences that lead to major knowledge gaps, all of which will be addressed by the SEAWave project. SEAWave will (i) quantify the differences in exposure patterns between 2G-4G and 5G for the entire population including children; (ii) provide new tools and instruments for reliable exposure evaluation of base stations, local networks in factories, and end-user devices; (iii) provide the means to minimise exposure; (iv) generate important new scientific data for assessing the health risk from exposure to the new frequency bands (FR2), especially with regard to the potential (co-)carcinogenicity of skin exposure and other hazardous effects; and (v) provide knowledge for effective health risk communication and dissemination to various stakeholders. To achieve these ambitious objectives, the interdisciplinary consortium consists of highly experienced partners with leading expertise in the field who ideally complement each other to achieve maximum impact. European citizens, workers, national public health authorities, European Commission services, regulators, and standardisation bodies will all benefit from the SEAWave results as they will support science-based decisions and policies for the safe deployment and use of 5G and future wireless networks. Project SEAWave is part of the European cluster on EMFs and health.

Keywords: emf monitoring,5g networks,millimetre waves,base stations,wireless devices,standardisation,children,elderly,skin cancer,epigenetics,risk assessment,risk communication,in vitro,in vivo
Simulation-Integrated Design and Development of 3D-Printed Shape Memory Polymer-Based Dynamic Electromagnetic Interference Shields (Sim3D-DynaShield)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

Electromagnetic interference (EMI) shielding is the mitigation of unwanted electromagnetic (EM) radiation, which hinders the smooth operation of electronic systems. Over time, EMI shielding research has advanced from static to smart shielding, where the shields dynamically respond to external stimuli (pressure, temperature, etc), providing real-time protection. However, existing research on smart/dynamic EMI shielding materials faces challenges in precision, sustainability, and integration, limiting their real-world applications. Current solutions often rely on porous petroleum-based materials such as polyurethane polymers, which lack microstructure control and require constant exposure to stimuli to maintain the ON/OFF state. Further, the high resource requirements and lack of pre-fabrication optimization in current research demand innovation. This proposal aims to address these challenges by leveraging simulation-integrated 3D printing techniques to design and develop various microlattice mesh structures based on sustainable polycaprolactone shape memory polymer integrated with conducting and magnetic nanoparticles for enhanced smart shielding ability. This pioneering and innovative approach of combining mechanical, thermal and EM simulation with 3D printing allows visualization, designing and meticulous analysis before fabrication, enabling real-time assessment of material responses under various stimuli and the creation of complex geometries with precision. In this proposal, a smart shield integrated prototype system for real world applications will be developed, addressing the crucial research gap associated with realizing device-integrable smart shields in a resource-efficient and sustainable manner. My experience in EM simulation-oriented investigations for developing rigid to flexible EMI shielding structures and substantial knowledge on microwave materials, that I gained during my PhD, will significantly aid in producing tangible outcomes from this proposal.

Keywords: emi shielding,dynamic emi shielding,smart shields,3d printing,electromagnetic simulation,mechanical and thermal simulation,shape memory polymer,microlattice structures,microstructure control
Dissecting the regulation, structural dynamics, and physiological role of human Ninj1 activity during Mtb-induced cell death on a molecular scale. (Ninj1 cell lysis)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 267418.56
EU funding (EUR): 267418.56
Participants: 1
Project status: SIGNED

Mycobacterium tuberculosis (Mtb) causes tuberculosis a leading infectious killer worldwide. Mtb primarily infects macrophages, leading to the death of some of these cells via distinct regulated cell death (RCD) mechanisms. While apoptosis facilitates Mtb elimination, necrotic cell deaths, like pyroptosis, necroptosis, and ferroptosis may enhance bacterial replication and spread. Mtb effectors, including the type VII secretion system ESX-1 and the cell wall lipid PDIM, induce host membrane damage, inducing necrotic cell death. Notably, the host lab has shown that inhibiting all RCD pathways does not prevent Mtb-induced cell lysis. However, depleting Ninjurin-1 (Ninj1), a membrane protein vital for plasma membrane (PM) rupture during various RCD pathways, mitigates Mtb-induced necrosis. Ninj1 oligomerization appears to occur after initial PM integrity disruption, yet the precise mechanisms governing Ninj1 activation and its role in Mtb-induced cell lysis remain unclear. I hypothesize that Ninj1 plays a crucial role in Mtb-induced lysis and that Mtb exploits this process through effector-mediated PM permeabilization. To investigate how Ninj1 oligomerization influences cell fate and the inflammatory response, I will leverage my expertise in super-resolution microscopy of pore-forming proteins alongside the host lab’s skills in Mtb infection biology. First, I will identify PM chemical and physical changes during RCD that correlate with Ninj1 oligomerization to elucidate the activation mechanism. Next, I will analyze Ninj1 dynamics and the functional impact of its macromolecular structures using DNA-PAINT super-resolution microscopy and long-term single-molecule tracking. Finally, I will determine whether Mtb activates Ninj1 via effector-induced PM damage and quantify the impact of this activation on the inflammatory response. This project aims to provide groundbreaking insights into cellular responses to Mtb and molecular inflammation research.

Keywords: mycobacterium tuberculosis,regulated cell death,ninjurin1,plasma membrane,super resolution microscopy
Phototherapy treatment for long-term COVID-19 patients (longCOVID-UVBtherapy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

As the number of COVID-19 cases grows worldwide, so does the number of those suffering from clinical parameters that last weeks to-months post initial recovery, termed long-COVID, with as much as 36.55% of survivors exhibiting long-lasting symptoms (e.g., weight loss, chest pain, cognitive and memory disorders, breathlessness) according to recent studies—an estimated ~157 million long-COVID adult patients worldwide to date. Clearly, this growing health problem represents a modern global medical challenge. This challenge is compounded by a knowledge gap regarding the causes and prevalence of long-COVID, leaving no effective treatments. As noted by The Lancet: “The scientific and medical communities must collaborate … and find effective treatments”. Based on findings from my ERC grant, supported by other COVID-related reports, I propose to validate a UVB radiation (phototherapy) protocol for the treatment of long-COVID patients. Our findings indicate that phototherapy induces an immunological shift that counters that of the COVID phenotype: from T helper (Th) 1 cells, which stimulate inflammation and cell-mediated immunity, to Th2 cells, which promote humoral immunity. Phototherapy is also expected to address a range of reported respiratory, cardiovascular, neurological, endocrine and metabolic long-COVID symptoms. Our PoC entails both validating via a clinical trial the proposed treatment, through a strong collaborative framework with Maccabi Healthcare Services, Israel’s second largest HMO, and conducting pre-commercialization steps to enable quick, easy dissemination on the global stage. Taken together, our value proposition is an effective, non-invasive, simple long-COVID treatment that can be implemented through already established phototherapy clinics worldwide, thereby offering immediate relief to long-COVID patients while simultaneously reducing the health and financial burden of severely overburdened health systems.
Maximising f-element oxidation states (MAX-FOX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1543941.0
EU funding (EUR): 1543941.0
Participants: 1
Project status: SIGNED

The applicant is a rising early-career scientist with an international reputation in frontier rare earth and actinide science. This StG project melds synthesis and electrochemistry with computational and spectroscopic methods to afford a transformative advancement in electronic structure and oxidation state control in f-elements. By advancing our understanding of the design principles which influence the properties of these complexes, we propose to maximise their stability and expand beyond the current approaches to isolate molecular lanthanide species in unprecedented high oxidation states. We target high oxidation state lanthanide (Ln), actinide (An), and transuranium f-element complexes beyond the current state-of-the-art by expanding to novel ligand platforms which address all key aspects to maximize the thermodynamic, and hence electrochemical, stability of these powerful oxidisers. We will show that the range limit of tetravalent Ln ions available to solution chemistry has not been reached. By accessing high oxidation states we will isolate multiply bonded motifs to Ln(IV) beyond Ce for the first time, including iconic organometallic linkages which offer unique spectroscopic (EPR and NMR) handles with which to probe the bonding in these systems. This will be extended to actinide and transuranium elements, affording unprecedented opportunities to gain insight into orbital energy vs spatial overlap components in bonding, and probe the relative magnitudes of inter-electronic repulsion, spin-orbit coupling, and crystal field effects in f-elements. An StG will provide resources required to bring this ambitious project to fruition. We will address the rarity of high oxidation state 4f-elements and define the chemical properties that can be leveraged to control their electronic structures. This addresses the Quantum Flagship, a key Horizon 2020 priority area, and will train a cohort of interdisciplinary scientists essential for the scientific goals of the EU.

Keywords: redox chemistry,lanthanides,actinides,high oxidation states,ligand design
SWEDISH PRESIDENCY CONFERENCE ON DEEP TECH ENTREPRENEURSHIP FOR AN INNOVATIVE, RESILIENT AND COMPETITIVE INTERNAL MARKET (SWEdeeptechCon)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Sweden
Call: Swedish Presidency Conference (HORIZON-EIC-2023-SWEDPC-IBA-01, 2023)
Start date: 2023-03-01
End date: 2023-10-31
Duration (months): 8.0
Total project cost (EUR): 411000.0
EU funding (EUR): 400000.0
Participants: 2
Project status: CLOSED

The internal market turned 30 in the beginning of 2023. It is one of the greatest successes of the union but the EU cannot rest on it laurels. There are several challenges to the internal market, including inflation, high energy costs, competition from global rivals, component supply shortages and the disruptions from the war in Ukraine. There is also an urgent need to push forward with the green and digital transitions. The deep tech sector, which is characterised by science-based revolutionary innovation, holds the key to make Europe globally competitive while at the same time bringing the next generation of clean technology to the market and reducing dependence on hostile counties. The European Commission has proposed several important initiatives to boost the EU’s competitiveness. Private sector, national and regional governments and other stakeholders can join forces to help push for the common aims. The Swedish government and the innovation agency Vinnova, together with the European Innovation Council, will host a presidency conference on deep tech entrepreneurship to provide a forum for knowledge exchange and co-implementation within the framework of the European Innovation Agenda and the Action Plan on Intellectual Property. The discussions will focus on the following areas: • The importance of research-intensive companies for the green and digital transformation • Financing for growth in Europe • Competence supply and diversity • Access to infrastructure for research-intensive young companies • Improved collaboration between small research-intensive companies and large companies and the public sector • Strategic use of intellectual assets The conference will the held at XPO conference centre by Stockholm Arlanda Airport, Sweden. 1-2 June 2023.
Bioinspired living skin for architecture (ARCHI-SKIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Slovenia
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1999000.0
EU funding (EUR): 1999000.0
Participants: 2
Project status: SIGNED

Biofilms, an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix, are recognised as one of the most stable biological systems on earth. The beneficial use of biofilms for protection is nearly unexplored since up-to-date research is focused on the prevention of its formation. In the ARCHI-SKIN project, we will explore the design principles underlying fungal biofilm to bridge the knowledge gap on the chemistry-structure-properties of the biological systems’ interface. Mechanisms of biofilm formation, its structure, function, quorum sensing, and performance will be understood at multiple scales following the best practices of materiomics. It will be achieved by advancing state-of-the-art in-situ laboratory routines and use the latest mathware solutions in combination with the design-build-test-learn approach for the experimental work. In the following step, we will develop a bioactive protective coating system working in conjunction with nature. We will benefit from the synergic strength of living fungal cells, bio-based ingredients, and bioinspired concepts for materials protection. Advanced in-silico methods will be used for the integration of active ingredients and modelling of optimal and long-lasting nutrient sources compatible with the enzymatic profile of selected fungal strains. We will design and create technically applicable, controlled, and optimized biofilm built by the yeast-like ubiquitous and widespread oligotroph fungus, Aureobasidium pullulans, that will effectively protect the surfaces of biomaterials, concrete, plastics, and metals, among others, assuring optimal service life performance and remarkable functionalities including self-healing and bioremediation. Our pioneering approach for materials protection will push the boundaries of traditional materials concepts toward the development of engineered living materials capable to interact, adapt, and respond to environmental changes.

Keywords: living coatings system,bioinspired materials design,engineered living materials,smart living surfaces
Cost-effective and Sensitive DNA Methylation Profiling for Advancing Single-Cell Epigenomics (MeTLAND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 195000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Epigenetic dysregulation is a key contributor to numerous major diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, underscoring the critical need for scalable and cost-effective profiling technologies. A central challenge in precision medicine is the heterogeneity in patient responses to treatment, which is influenced by inter-individual epigenetic variability. DNA methylation, a fundamental epigenetic modification, plays a central role in disease pathogenesis and therapeutic outcomes. However, existing methylation profiling methods, such as whole-genome bisulfite sequencing (WGBS) and affinity-based enrichment approaches, are hindered by high costs, technical complexity, and DNA degradation associated with harsh chemical treatments. To overcome these limitations, we developed MeTLAND, an innovative enzyme-based DNA methylation profiling method that enables efficient and selective detection of methylated regions in a single-step reaction. This streamlined, single-step workflow significantly reduces sample processing time, degradation, and cost. Designed to be broadly compatible with established genomics platforms, MeTLAND also supports integration with other epigenomic assays, facilitating multimodal data generation. Its compatibility with bulk, single-cell, and spatial epigenomic applications further enhances its versatility. With the global epigenomics market valued at $17 billion, MeTLAND addresses the growing need for accessible, high-sensitivity methylation profiling, positioning it as a transformative tool for both research and clinical applications.
Two-Faced Hopes: Football, Migration, and Religion Between West Africa and Europe (JANUSHOPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-12-31
Duration (months): 27.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 3
Project status: SIGNED

Since the 1990s and the commercialization of global football, an increasing number of young people in countries like Ghana, Ivory Coast, and Cameroon have aspired to play football as a career, a strategy to migrate abroad (ideally Europe), and an opportunity for social and class mobility. For the majority, however, the dream does not come true. International media and human rights organizations regularly report about thousands of young West Africans victimized by deceitful agents, stranded as undocumented migrants, and playing for clubs under exploitative conditions. And yet, young people continue to train to migrate and play. Scholars have studied these football-related migrations, but they have overlooked the fact that religions, especially Pentecostal Christianity and Islam, play a central role in migrants’ hopeful journeys. This project investigates the intersection of football, migration, and religion among African migrants in Europe in order to study hope, conceptualized as a belief that something desired may occur in the future. It makes a crucial critical intervention: while many interdisciplinary studies assume a depoliticized notion of hope and romanticize its positive and constructive qualities, JANUSHOPE also examines the dark side of hope that perpetuates inequality and exploitation. It turns to African “irregular” football migrants in Europe to understand how a critique of the global industry’s dark side of hope might co-exist with hopes for “making it” in the industry. It investigates how their faith-based narratives of hope might both critique and reproduce inequalities of global capitalism and transnational migration. The key research methods are semi-structured interviews and ethnographic fieldwork with “irregular” African football migrants in Europe. The results will be disseminated through refereed articles and communicated to a wide global audience interested in football and to key European policy makers in fields of migration and human rights.

Keywords: hope,migration,religion,football,europe,africa