Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-Density Peptide MicroArrays and high-throughput, label-free detection of peptides, modifications and interactions (HIPAD)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Denmark,France,Italy,European organisations area,Germany,Germany,United Kingdom,United Kingdom,Denmark,Denmark
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2016-04-30
Duration (months): 52.0
Total project cost (EUR): 6382419.95
EU funding (EUR): 4823014.0
Participants: 10
Project status: CLOSED

Proteins are extremely malleable building blocks of life involved in all aspects of biology. Many diseases are caused by proteins aberrations, and proteins are frequent targets of intervention. Mapping all proteins and their functions are expected to yield pervasive medical and biotechnological benefits. However, even the most comprehensive and high-throughput proteins discovery technologies are seriously challenged by the extreme diversity and low abundance of many proteome components; a problem, compounded by the lack of affinity reagents and validated probes for sample preparation and identification. Our concept is that shorter protein fragments, or peptides, may offer solutions to many of these problems as peptides may represent or mimic proteins. Using in situ solid-phase peptide synthesis, computerized photolithography and novel photochemistry, we have recently generated peptide microarrays of up to 2 million addressable peptides. This unprecedented high-density and high-content peptide microarray technology could make inroads into the kind of high-throughput analysis needed to address the entire human proteome. Here, we aim to exploit this potential by using and improving three different, yet complementary, label-free detection technologies allowing sensitive, high-resolution determinations of the identity, quality and/or modification of individual members of a peptide microarray, and real-time monitoring of any interacting molecular receptor. We will also develop peptides as rapid, specific, and renewable affinity reagents for complex sample preparation, and develop peptides as probes and complex biosensors. Three SME’s constitute the backbone of this collaboration, receiving 50% of the budget, and enjoying significant opportunities from the booming protein/peptide microarray market. Furthermore, solutions to these unmet needs of proteomics are believed to have incalculable benefits for European health, innovativeness and competiveness.
Development of a nanomechanical tool-box for the investigation of cell mechanics (NANOFORCELLS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Spain
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1492854.0
EU funding (EUR): 1492854.0
Participants: 1
Project status: CLOSED

The fact that biophysical and biomechanical properties of cells and subcellular structure influence and are influenced by onset and progression of human diseases is now attracting the physiologists attention. This opens up new routes for disease diagnosis and treatment. The first traditional way to discover a tumor was by palpation, such as sweetness in urine was indicative of diabetes. Nowadays, the biochemical search for diagnosis markers has experienced amazing advancements, while the physical cues have remained almost forgotten; this is mainly due to a lack of powerful tools able to unravel the mechanics of individual cells. This proposal aims to develop a set of tools and demonstrate their potential for the throughout study of individual cell mechanics and sub-cellular structures. The proposed tools will provide the route to develop mechanical and physical assays to extract the elastic and viscoelastic deformability of f.e. cancer cells as compared to healthy cells, providing with mechanical biomarkers for diagnosis. NANOFORCELLS proposes an innovative approach combining optical interferometry together with advanced nanomechanical systems and AFM local characterization. This mechanical lab for cells will provide new knowledge that can not be attained today with present technologies. Also, the proposed nanomechanical devices of this project will provide not only a direct measurement for single cell rigidity but the capability for parallel measurement of hundreds of individual cells per minute, opening the route for portable tests that could prove very general to determine the health status of cells from blood samples. Also, interaction of cell with the environment can be studied in real time and thus the devices will provide tools for the study of drug effects and drug delivery vehicles, or for the assessment of the toxicity of nanoparticles.

Keywords: instrumentation,optics,nanomechanics,nanosensors,nanobiotechnology,diagnosis,cell biology,cancer
Relevance of double strand break repair pathway choice in human disease and cancer (DSBRECA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Spain
Call:  (ERC-2011-StG_20101109, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1416866.0
EU funding (EUR): 1416866.0
Participants: 1
Project status: CLOSED

Double strand breaks (DSBs) repair is essential for normal development. While the complete inability to repair DSBs leads to embryonic lethality and cell death, mutations that hamper this repair cause genetically inherited syndromes, with or without cancer predisposition. The phenotypes associated with these syndromes are extremely varied, and can include growth and mental retardation, ataxia, skeletal abnormalities, immunodeficiency, premature aging, etc. Moreover, DSBs play an extremely relevant role in the biology of cancer. Alterations in the DSBs repair pathways facilitate tumour progression and are selected early on during cancer development. On the other hand, DSBs are the molecular base of radiotherapies and chemotherapies. This double role of DSBs in both, the genesis and treatment of cancer makes the understanding of the mechanisms that control their repair of capital importance in cancer research. DSBs are repaired by two major mechanisms that compete for the same substrate. Both ends of the DSB can be simple re-joined with little or no processing, a mechanism known as non-homologous end-joining. On the other hand, DSBs can be processed and engaged in a more complex repair pathway called homologous recombination. This pathway uses the information present in a homologue sequence. The balance between these two pathways is exquisitely controlled and its alteration leads to the appearance of chromosomal abnormalities and contribute to the diseases aforementioned. However, and despite its importance, the network controlling the choice between both is poorly understood. Here, we propose a series of research lines designed to investigate how the choice between both DSBs repair pathways is made, its relevance for cellular and organismal survival and disease, and its potential as a therapeutic target for the treatment of cancer and some genetically inherited disorders.

Keywords: checkpoints
Advanced Network Coding for Video Surveillance (CODELANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece,Portugal,Spain,Germany
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 1811529.0
EU funding (EUR): 1811529.0
Participants: 4
Project status: CLOSED

CodeLance is about an industry-academia cooperation that will exploit the know-how on ICT of both academic and commercial companies, in order to provide an efficient product for video surveillance over wireless multihop networks to support services like, traffic monitoring, fire detection and real-time events (such as natural disasters) broadcasting for the societies of the smart cities. Video surveillance is an extremely demanding service in terms of QoS provisioning, security and delay guarantees, and requires high-performance wireless networks. Towards this goal, CodeLance will employ advanced network coding and security techniques, exploiting the research capacities of its two academic partners. On the other hand, the integration of these mechanisms over a video surveillance product necessitates the involvement of commercial partners who will ensure that all practical issues and parameters will be addressed in the protocol architecture and that the designed protocols will be backward compatible with existing hardware. Towards this goal, two SMES will participate in CodeLance to provide their significant industrial and technological expertise. The design of the final video surveillance product requires the strong collaboration, equipment sharing, and excess of knowledge transfer between academic and commercial partners to bridge the gap between the theoretical approaches and a ready-to-implement video surveillance protocol. This cooperation will take place through inter-sector two-way secondmends of research staff with in-built mechanisms and organisation of training seminars, trans-national workshops and other networking activities to facilitate sharing of knowledge and culture between the participants. Moreover, recruitment of experienced researchers from outside the partnership will broaden the knowledge transfer and bring an added-value to the consortium.

Keywords: technological sciences,telecommunications engineering,wireless systems,computer technology,software technology
Novel Compact Terahertz source based on Dual Wavelength Lasers and Photomixers (TERA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Lithuania
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 1104208.0
EU funding (EUR): 1104208.0
Participants: 2
Project status: CLOSED

TERA proposes to perform a joint industry academia research programme capitalising on the knowledge and expertise of the partners through exchanges of researchers and transfers knowledge between research centres in Photonics and Nanoscience at the University of Dundee and SME UAB TERAVIL with expertise in different aspects of laser physics, material science and THz radiation. The aims are to overcome scientific and technical barrier to the realisation and adoption of low-cost technologies for the fabrication of compact room-temperature terahertz sources emitting few tens of W powers at 0.3–1.5 THz and beyond for Biophotonics and Safety and Security applications. The THz radiation will be obtained by difference frequency generation from CW or pulsed dual wavelength laser produced by combination of laser diodes with novel volume Bragg reflectors . Together the project partners will evaluate several variants for the THz generation procedures. Photoconductive mixers based on traditional and new materials and photovoltaic travelling-wave mixers will be assessed, targeting increased conversion efficiency

Keywords: technological sciences,optronics,materials engineering,electronic engineering
Reinforce Organic Electronics Research Potential in Kentriki Makedonia (ROLEMAK)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Greece
Call:  (FP7-REGPOT-2011-1, 2011)
Start date: 2011-09-01
End date: 2014-12-31
Duration (months): 40.0
Total project cost (EUR): 3072780.0
EU funding (EUR): 2740220.5
Participants: 1
Project status: CLOSED

Organic Electronic Devices (OEDs) are considered the next scientific and technological revolution. The structure of an OED involves a stack of thin films from active (organic small-molecule and/or polymers semiconductors) and passive materials (inorganic or organic conductors for electrodes and barrier layers). Most of the supported research entities and industries in the field of OED development are activated mostly in central Europe and thus they became indicators for high innovation potential. However, in EU’s convergence regions, like Kentriki Makedonia (KM) in Greece, there are academic departments with limited human resources and infrastructure but successful contribution in OED that could create excellence and development in this region. For example, the labs of Physics Department (PD) from Aristotle University of Thessaloniki (AUTh) in KM are strongly involved in FPs in the fields of thin film and material technology, flexible polymeric materials and high barrier layers for encapsulation of flexible OED. In order to establish a framework for strong collaboration between Greek and the European research groups and to become more competitive within EU, AUTh team is proposing the ROleMak Project. The objectives of ROleMak are: i) Boost the S&T potential and extend the knowledge & competences of AUTh to OEs by strategic partnership & collaborations with excellence in OEDs, ii) Recruit experienced scientists with established expertise in OEs to work with the AUTh team, iii) Upgrade the research infrastructure of AUTh with cutting edge equipment, in order for AUTh to become competitive in the field , iv) Organize Dissemination activities in OEs within Greece and Europe, and v) Exploit the acquired results by organizing promotional events (round tables and stakeholder meetings), integration & networking through EC projects. The above will boost the research potential of KM and the Physics Department of Aristotle University of Thessaloniki and establish a leading excellence research center in Southeast Europe.

Keywords: organic electronics,flexible electronic devices,polymers and small molecules organic materials,organic photovoltaic cell,organic thin film transistor,biosensor
High performance Anaerobic digesters for the treatment of medium size wineries’ effluents (AD-WINE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Germany,France,Spain,Italy
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 777706.0
EU funding (EUR): 777706.0
Participants: 5
Project status: CLOSED

The aim of the AD-WINE project is to offer the opportunity for researchers from academic and industrial backgrounds to exchange knowledge and work together, in order to develop a common project in the field of anaerobic digestion and environmental solutions applied to the wine sector. This industry, which processes millions of tons of grapes every year, has consequences on the environment. The nature of the pollution generated by wineries is mainly organic, but mineral residues, earth, grease, detergents and disinfectants, toxic exogenous contaminants located in the grapes are also generated. This project aims to develop an anaerobic treatment system, using high performance digesters adapted to the treatment of medium size wineries’ effluents. The development of such digesters would help to lower the energy and operation costs of the plant, as well as significantly reducing the production of sludge and residues, and allowing a better valorisation of by-products and biogas. Thanks to the participation and exchange of personnel, the AD-WINE project partners will create an effective network of research and will collaborate in order to study this treatment system and develop a prototype. This will offer wineries an alternative to other current ways of treating water, offering countless environmental and economical advantages, and would allow the wine sector to comply with the legislation and the European objectives in terms of production of renewable energies. By participating in this project, the non-commercial research participants will have the opportunity to give a practical and commercial value to their research, whilst for the participating SME, it is the chance to gain knowledge on cutting edge technology and to develop innovative products, enhancing its growth and expansion prospects.

Keywords: water resources engineering,plant biotechnology,biogas production,environmental technology,effluents,anaerobic digestion
Nano- Electrospun Filter for Efficient Liberation & Encapsulation of acticides for water treatment in transportation applications (NEFELE)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,Italy,United Kingdom,United Kingdom,Türkiye,Spain,Norway
Call:  (FP7-SME-2011, 2011)
Start date: 2011-12-01
End date: 2013-11-30
Duration (months): 24.0
Total project cost (EUR): 1073477.49
EU funding (EUR): 830011.65
Participants: 7
Project status: CLOSED

In recent years, word of aircraft water quality issues has spread, generating negative media coverage, attracting the attention of regulators worldwide, and giving airline passengers a new cause for concern. Health enforcement agencies are currently in the process of drafting new, more stringent quality regulations for aircraft potable water and the world's other regulators will follow suit. Aircraft potable water is typically loaded from municipal systems which are susceptible to contamination. While municipal water quality has always been a concern in some parts of the world, it is now becoming an issue in North America as well. As recent outbreaks of waterborne disease in carries Canada and the US illustrate, dependence on any municipal water supply carries an inherent risk. Even when the source water is clean, contamination can make its way into a water supply during ground handling because of contaminated water trucks, contaminated hoses, or from improper handling procedures by ramp crew. The aircraft water system itself can be the source of contamination. Microorganisms can grow within the water tanks, water lines, and even the water filters. This situation is exacerbated by the standard, air pressurized water systems that allow water to remain still in the tank and distribution lines until a faucet is opened and the water begins to move. Bacteria thrive in such conditions, which also encourage bacterial regrowth almost immediately after system cleaning. The present project aims to provide an advanced treatment system which will make use of core/sheath polymer nanofibres which are filled with biocidal substances. This will provide a way of maintaining a constant level of biocide in the water without the need to dose or measure the quantities present. In addition the nanofibres will provide a means of physical entrapment for viruses.

Keywords: nanofibres,electrospinning,microfluidics
Aircraft for Environmental and Forest Science (AIRFORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,Austria
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 1012298.0
EU funding (EUR): 1012298.0
Participants: 2
Project status: CLOSED

Up-to-date environmental science builds upon of highly standardised monitoring networks and global scale earth observations. But a missing scale in ecosystem monitoring still exist to properly bridge observations which are made at the leaf/canopy to the global scales. Aircraft and airborne sensors are ideal to operate at such “missing scale”. Aircraft can be used to operate a range of sensors to monitoring atmospheric properties along vertical profiles, to perform surface flux measurements using airborne eddy covariance techniques and to deploy different types of remote sensing equipment. Airborne science has considerably grown over the last few years, together with the advent of a new generation of airborne sensors. Despite recent efforts such as the Eufar Project, the use of airborne platform for environmental research still remains limited. The reason for this may be found in the existence of a major cultural gap between users and providers. AIRFORS is designed to fill this gap bringing together a public organization engaged in environmental research (FEM) and a private company (AT) with excellent records in conducting airborne measurements and campaign and in operating up-to-date airborne sensors. In this way it will contribute substantially to the development of a transnational public-private partnership aimed at the promotion of unique earth observation and atmospheric measurement infrastructure, at multiple scales.

Keywords: natural sciences,physical sciences