Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Three Rapid Diagnostic tests (Point-of-Care) for COVID-19 CoronaThree Rapid Diagnostic tests (Point-of-Care) for Coronavirus, improving epidemic preparedness, public health and socio-economic benefits (CORONADX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Italy,China,Sweden,Sweden,Denmark,Denmark
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2023-09-30
Duration (months): 42.0
Total project cost (EUR): 2970208.76
EU funding (EUR): 2970208.74
Participants: 10
Project status: SIGNED

On 30th January 2020 WHO declared a global health emergency for the outbreak of the 2019 novel Coronavirus (COVID-19, or 2019-nCoV) that originated in Wuhan, China. COVID-19 has spread to 27 countries and with 45204 confirmed cases and 1118 deaths (12th Feb 2020), this outbreak exceeds the SARS epidemic in 2002-2003 both in terms of infected and death toll. Diagnostic tests are essential to control the outbreak. The Chinese authorities issued Emergency Use Authorizations (EUA) for 4 new COVID-19 detection products by the end of January 2020 and in the US the FDA issued the first EUA on February 4th. These tests are, however, all based on methods suited only for well-equipped centralized laboratories. CORONADX will provide one “front line” and two “second line” diagnostic tools for COVID-19. The “front line” diagnostics can be performed as a fast, simple, point of care test (POC) in the field by a minimally trained person (e.g. at hospitals or clinics, at point of entry, in a plane, on a cruise ship, in an ambulance, on a parking lot, in a home quarantine setting etc.). The “second line” diagnostics require minimum (portable) equipment and can be performed by briefly trained personnel in hospitals, primary health care units or in mobile laboratories. These solutions will be available in month 4 and EUA applications will be submitted by month 7. These POCs with lab and field evaluations will allow for fast detection and surveillance of the epeidemic and greatly improve the diagnosis and clinical management of patients infected with COVID-19. The development of rapid POC diagnostics will be supported by clinical and molecular epidemiological studies on the characterization and spatio-temporal evolution of the COVID-19 virus and identify infection sources as e.g. the animal reservoir.The social sciences research in CORONADX will provide information on societal resilience in the era of social media, and the related public health preparedness.

Keywords: point of care instruments,epidemiological studies,socio economic studies
Open Design of Trusted Things (OpenDoTT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,India,Italy,Netherlands,United States,United Kingdom,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1515862.8
EU funding (EUR): 1515862.8
Participants: 11
Project status: CLOSED

Open Design of Trusted Things (OpenDoTT) is a doctoral (ESR) training programme that uniquely brings together design research and open internet advocacy to respond to a rapidly growing need for trusted Internet of Things (IoT) products and services. Working with a network of international partners with expertise including open hardware, design, security and law, OpenDoTT will develop future leaders that have the capability and capacity to meet the many challenges and opportunities presented by the increasing impact of IoT, making Europe a global leader in this field. As the internet becomes increasingly pervasive, more devices, vehicles, appliances and other items are becoming capable of connecting and exchanging data. It is estimated that IoT technology will be in the majority of electronics for new product by 2020. While IoT holds many promises for humanity, there are also a significant number of pressing concerns, including: (i) the increasing integration of connected technologies into all aspects of our lives, increases our vulnerability to new threats; (ii) there is a trend towards closed, single-platform consumer products and services that stifle innovation and limit competition and ownership; and (iii) awareness and consent becomes increasingly problematic as technology ‘disappears’ into everyday objects. OpenDoTT responds to these challenges by training a cohort of future researchers and leaders capable operating at the intersection of technology, society and policy. Design research approaches will provide the ability to address complex problems with unknown and emerging requirements, while open internet values will ensure that ESRs strive for the most positive and beneficial societal outcomes for IoT. With support from a diverse consortium spanning academia, the tech industry, SME IoT communities, legal and policy expertise, security experts, open source hardware and the public sector, ESRs will be uniquely suited to change the shape of IoT for the better.

Keywords: the internet of things,open hardware,open innovation,participatory design
Metal-catalyzed remote functionalization of aliphatic amines and amides triggered by photocatalytic sp3 C-H activation (PHOTO-WALK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-03
End date: 2022-05-05
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Activation of traditionally inert bonds has attracted great attention in the last decades and impressive advancements have been achieved in the catalytic functionalization of CH bonds. Although the great number of catalytic methodologies for the transformation at sp2 CH sites, manipulation of the corresponding sp3 CH bonds remains largely confined to activated allylic and benzylic positions or to sites within reach of an existing directing group. Transition metal-catalyzed olefin isomerization has provided an outstanding tool for remote functionalization of sp3 CH bonds but it requires the use of prefunctionalized molecules, bearing a component or an alkyl bromide. On the other hand, photocatalysis has emerged as a novel strategy for sp3 CH activation but it is limited to the functionalization at the or positions with respect to a heteroatom. PHOTO-WALK will merge the photocatalytic activation of sp3 CH bonds with a Ni-catalyzed chain-walking process, disclosing a completely novel triggering event for the remote functionalization of unactivated aliphatic amines and amides. The approach will overcome the limitations of current strategies for remote functionalization, allowing transformations at sp3 CH sites unreachable by current photocatalytic methods and employing hydrocarbon feedstocks (aliphatic amines and amides) lacking of C=C or C-halide handles. Three functionalizations have been envisioned to increase molecular complexity by forging new C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds: i) remote carboxylation, ii) remote arylation and iii) remote alkylation. PHOTO-WALK has the potential to be applied to the late-stage derivatization of pharmaceuticals, enabling the exploration of uncharted chemical spaces and offering the opportunity for structural diversification in drug discovery.

Keywords: remote functionalization,metallaphotoredox,photocatalysis,c h activation,cross coupling,carbon dioxide,feedstock,isomerization,chain walking,radicals,light,nickel,iridium
Enhance innovation management capacities in Andalusian SMEs. CESEAND InnoAses 2015-16. (CESEAND InnoAses2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Spain
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 305012.0
EU funding (EUR): 305010.0
Participants: 5
Project status: CLOSED

The European Commission has placed a firm wager on an "industrial renaissance" in which SMEs are to play a leading role. Within this context, the role the new Community instruments have assigned to the Enterprise Europe Network, as a European-wide network of entities integrated into regional innovation systems, is that of being the lever and driving force for innovation management capacities in SMEs and, in the near future, as the organisation directly responsible for the provision of advanced services. Innovation properly combined with cooperation and internationalisation, is the only path along which SMEs can improve their competitiveness in a globalised world undergoing an industrial crisis. Therefore, our main objective is to contribute to smart growth in Andalusia, through the provision of services enhancing the innovation management capacities of Andalusian SMEs. According to this call, these are the Project's Objectives expected to be attained through this project's development and implementation: • To enhance the innovation capacities of SMEs in Andalusia in order to make them more competitive through the provision of advanced services. • To drive forward non-technological catalysts for innovation in SMEs. • To develop on behalf of the entities which comprise the Enterprise Europe Network new ways and tools to provide services to SMEs that contribute to enhancing their competitive capacities. • To provide support to beneficiaries of SME Instrument, accompanying them in their transition through Phases 1 and 2. • To identify future potential applicants to successfully take part in SME Instrument. • To develop methodologies that can be enhanced through their integration into the Andalusian Innovation Ecosystem.

Keywords: action establishing services enhancing the innovation management capacity of sme s in the enterprise europe network
Financial Decision Making with Endogenous Information Acquisition (Endogenous_Info)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2020-05-31
Duration (months): 48.0
Total project cost (EUR): 1588958.75
EU funding (EUR): 1588958.75
Participants: 1
Project status: CLOSED

Are financial markets informationally efficient? Are some economic agents more informed than others? What is the impact of such heterogeneity on asset prices? These questions, of great economic significance, have permeated academic and business circles over the last few decades. Despite significant progress on the theoretical and empirical fronts relatively little is known about how information is endogenously acquired and processed in markets by agents with differential access to information and facing heterogeneous opportunities. Using the novel setting of endogenous information acquisition with non-trivial heterogeneity the project has two goals: (A) to lay out micro foundations for informed trading in investment and corporate settings using the contexts of illegal insider trading and household finance; (B) to investigate macro implications of heterogeneous information for global economic phenomena such as income inequality, organizational design, and market power.

Keywords: information frictions,financial markets,asymmetric information,institutional investors,income inequality,insider trading
The Unfolded Protein Response in Neurodegeneration (UPR NEURO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1979286.0
EU funding (EUR): 1979286.0
Participants: 1
Project status: CLOSED

This proposal aims to increase our understanding of the role of translational failure in human neurodegenerative diseases. We recently discovered the mechanism by which protein misfolding leads to neurodegeneration in prion disease. The pathway involved is a generic cellular pathway, a branch of the unfolded protein response (UPR) that controls protein synthesis at the level of initiation of translation. Rising levels of misfolded prion protein cause sustained over-activation of the PERK-eIF2α branch of the UPR in neurons resulting in an uncompensated decline in global translation rates, synaptic failure and neuronal death. Reduction of eIF2α-P levels by genetic manipulation or by pharmacological inhibition of PERK, rescue vital translation rates and prevent neurodegeneration and clinical disease in prion-infected mice. There is increasing evidence that UPR dysregulation is a central process in protein misfolding neurodegenerative diseases, and that maintaining translation levels is essential for neuronal health. Raised levels of PERK-P and eIF2α-P occur in brains of patients with Alzheimer’s (AD), Parkinson’s (PD), and related diseases. The pathway is also implicated in learning and memory; manipulation of eIF2α-P levels boost cognition in wild type mice and restore memory deficits in AD mouse models. We will test for over-activation of PERK/eIF2α-P and the effects of its manipulation in other models of neurodegenerative disease. We will generate new transgenic mouse models that isolate translational failure from specific misfolded proteins and use these to gain valuable new insights into the window for intervention when neurons can still be rescued, the selective vulnerability of different neuronal populations, and the role of the UPR in neurons and glia. Collectively, the aim is to increase insight into the role of UPR-mediated translational failure in human neurodegenerative disease and determine its tractability for the treatment of dementia.

Keywords: unfolded protein response
New Approaches to Metallo-β-Lactamase Inhibitors (MBLIs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The increasing problem of antibiotic resistance is a major global public health concern. In the EU 25,000 patients die each year due to infections caused by multi-resistant bacterial pathogens, and the EU spends at least 1.5 billion euro per year on healthcare costs. The β-lactam antibiotics are the most important antibiotics representing >60% of small molecules in clinical use. BLAs contain a β-lactam ring which is critical for penicillin-binding protein inhibition. However, BLA efficacy is declining due to resistance mechanisms including the widespread occurrence of β-lactamases, which catalyse β-lactam hydrolysis. Metallo-β-lactamases, long-considered as of little clinical relevance, now present a serious global threat to almost all BLAs, rendering the development of approaches to MBL inhibitors important. Unlike the serine β-lactamases, the MBLs are structurally and mechanistically unrelated to PBPs, and are not inhibited by current mechanism-based SBL inhibitors. Due to variations in MBL structures, a major challenge in MBL inhibition is the development of compounds with the breadth of selectivity necessary for clinical utility. Society is now in an alarming situation and there is a clear need for the development of an MBLI:β-lactam-based combination therapies. The aim of my proposed work is to pioneer, enable and inspire the generation of broad-spectrum MBLIs active against a panel of clinically representative MBLs, but inactive against human enzymes with related active sites. To obtain the desired objective, novel approaches are proposed and include the use of phosphonates and phosphinic acids for: (a) MBL-directed DCC coupled to analysis by non-denaturing ESI-MS and 31P-NMR, (b) 31P-NMR reporter screening method, (c) pre-equilibrated DCLs for MBL-directed DCC, and (d) the synthesis of modified inhibitors. The study will be interdisciplinary and encompass organic synthesis, biological MS/NMR, structural biology, and medicinal chemistry.

Keywords: lactam antibiotics,antibiotic resistance,metallo lactamases,broad spectrum mbl inhibition,dc chemistry,protein ms and 31p nmr,phosphonates,phosphinic acids,pre equilibrated dcc
Demarginalizing Medieval Georgia: The History of Art History between Colonial Perspective and Nationalist Appropriation (1921–1991) (DeMGeo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2026-12-30
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: SIGNED

Characteristic by indisputable quality and profound cultural syncretism, the art of medieval Georgia arose from a cultural crossroads between Europe and Asia and has unjustly been put off the side-lines of the art historical canon. The marginalization is due in large part to historiographic factors. Russian and Western scholars presented it from a colonial perspective as the art of the Byzantine periphery, analogous to the marginal political position of the South Caucasus within the USSR. In contrast, Georgian scholars throughout the 20th century were determined to demonstrate that Georgian “national” medieval art was fully autonomous and original. That reflected the Georgian impulse to achieve political autonomy within the Soviet Union. Deploying methods proper to the epistemology of art history, DeMGeo aims to investigate the historiographic construction of the three dominant narratives – Russian, Western, and Georgian – developed in art history textbooks about Georgian medieval art, within the context of the 20th century political and social history. By revealing and deconstructing political and ideological strategies in past scholarship, the ambition is to de-marginalize Georgian medieval art and to prepare the terrain for new research in the field within the framework of a transcultural approach. The results will be applicable for other marginalized art histories marked by contested historiography, specifically in the context of the countries behind the Iron Curtain, and/or of the young nation-states born from multi-ethnic empires. The project is in line with EU cultural diplomacy, contributing to debates about World cultural heritage as a peace-building and soft power tool in societies marked by conflict. DeMGeo will be targeted at diverse audiences, thanks to the support of the CEMS (HI), developing and applying innovative methods in the communication of academic research.

Keywords: medieval art of georgia,south caucasus,philosophy of art history,female scholars in the ussr,soviet historiography,power knowlegde nexus,nation building through art history,soviet georgia
Role of GABAergic interneurons in the formation of new memory traces in the Dentate Gyrus of behaving mice (IN-Fo-trace-DG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-06-30
Duration (months): 69.0
Total project cost (EUR): 2463693.0
EU funding (EUR): 2463693.0
Participants: 1
Project status: SIGNED

Despite intensive study in the past on the problem of how information is processed in the brain to enable individual organisms to adapt to their continuously changing environment, little progress has been made on how new similar but discrete memory traces emerge in neuronal networks during learning. Current theories suggest that experience-dependent modifications in excitation-inhibition balance enable a selected group of neurons to form a new cell association during learning which represent the new memory trace. It was further proposed that particularly GABAergic inhibitory interneurons (INs) have a large impact on population activity in neuronal networks by means of their inhibitory output synapses. However, how cell associations emerge in space and time and how INs may contribute to this process is still largely unknown. This complex topic was so far difficult to address due to technical constraints. IN-Fo-Trace-DG aims to address this fundamental question in the dentate gyrus (DG), a brain structure essential for the acquisition of similar but discrete new memories. Based on our detailed knowledge on DG’s cellular elements, their interconnectivity and our recently established molecular interference tools, we will first, visualize the spatial and temporal activity patterns of cell populations during spatial learning in a virtual-reality using 2-Photon imaging. Second, we will determine the role of IN recruitment and plasticity in assembly formation by optogenetic and molecular interference. Third, we will analyze changes in excitatory and inhibitory signals in granule cells (GCs), the principal cells in this brain area, and INs during learning using whole-cell recordings in vivo. Finally, we will examine whether adult-born GCs contribute differently to learning-associated population activity compared to mature ones in the adult DG. This innovative multi-disciplinary approach will provide new insights on the mechanisms of new memory formation in cortical networks.

Keywords: population imaging,gabaergic interneurons,dentate gyrus,synaptic plasticity,synaptic,transmission,in vivo recordings,population activity,structural plasticity,parvalbumin