Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sleeping While Awake: Sleep intrusions during wakefulness and their cognitive consequences (SleepingAwake)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499686.0
EU funding (EUR): 1499686.0
Participants: 2
Project status: SIGNED

What happens in our brains when we get tired? Mental fatigue can occur for diverse reasons, through extended periods of wakefulness or following intense cognitive efforts. In other words, fatigue can be both time and use-dependent. My core hypothesis is that both processes are underpinned by local intrusions of sleep in the awake brain. Sleep and wakefulness are not mutually exclusive states. When animals are sleep deprived, high-amplitude slow waves (SWs), a hallmark of sleep, can be locally observed in awake individuals. These wake SWs have been linked to impaired cognitive performance. I have further shown that these wake SWs can be observed without sleep deprivation when participants perform demanding tasks. These wake SWs predict objective (errors) and subjective (e.g., mind wandering) markers of attentional lapses. However, the underlying mechanisms driving SWs remain unclear; why do they occur? How well do they predict the cognitive consequences associated with fatigue? And can they be externally modulated? To answer these questions, I will first describe the physiological signatures of wake SWs, from single-neuron to whole-brain activity. Second, I will seek to explain the occurrence of wake SWs by testing their association with the metabolic changes within the brain. Third, whereas wake SWs have been so far associated with adverse behaviors (lapses of attention), I will examine whether wake SWs could also predict positive outcomes, such as creative insights. Finally, I will investigate the possibility of modulating wake SWs and improving cognitive performance. Through this project, I will build a novel neurophysiological account of fatigue from the ground up by describing what local sleep is, explaining why it occurs, predicting its adaptative purposes, and modulating how frequently it occurs. This ambitious research program will generate critical novel insights into the neural mechanisms underlying the everyday phenomenon of fatigue.

Keywords: sleep wakefulness attention mental fatigue mind wandering behavior cognition consciousness neurophysiology metabolism human intracranial recordings electroencephalography magnetic resonance imaging
The Interplay of Children’s and Parents’ Networks in Shaping Each Other’s Social Worlds (ChiParNet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1496538.0
EU funding (EUR): 1496538.0
Participants: 2
Project status: SIGNED

As our social worlds remain divided by categories such as ethnicity, religion, and social class, attenuating social boundaries is paramount to creating equal opportunities and building cohesive societies. Segregated networks mark boundaries from childhood on and persist through adolescence and beyond. Research stresses parents’ influence on children’s contacts, but it largely neglects that children also influence their parents’ contacts. If we do not account for the interplay of children’s and parents’ networks, we may draw wrong conclusions about how segregation emerges and under which conditions it persists or diminishes. Since younger generations are more diverse, we must understand whether children adopt their parents’ network structures or whether diversity in children’s social lives also diversifies the social worlds of their parents. My project aims to advance our knowledge of mutual intergenerational boundary-making by developing and testing a theory of how child–parent networks co-evolve over time in educational settings with varying degrees of diversity. I propose to collect an innovative panel dataset of children’s and parents’ networks for multiple cohorts from kindergarten to secondary school. These unique data will allow me to rigorously examine how the interplay of children’s and parents’ networks affects boundaries in each other’s social worlds and how this varies by children’s age and diversity in educational settings. By showing how children and parents shape each other’s social worlds, the project will provide decisive new insights into the (bi)directionality and conditions of the intergenerational reproduction of social boundaries. This will change our understanding of segregation and break new ground in the interdisciplinary fields of intergroup relations, family studies, and network science. The results of the project will create a firm scientific basis on which policymakers can develop measures to reduce boundaries between future generations.
Tommaso Garzoni's Encyclopaedia of Wonders and the European Debate on Superstition and Marvels of the late Renaissance (GARZONI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-15
End date: 2028-01-14
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

This innovative, interdisciplinary project aims to provide the first historical and philosophical analysis of Tommaso Garzoni’s understudied encyclopaedic work on wonders "Il serraglio degli stupori del mondo" (1613) within the context of late Renaissance debate on marvels. The Protestant denial of Purgatory ignited a heated debate over the spiritual status of ghosts, sprites and spirits, which were understood as diabolical manifestations. This debate spread over time, engulfing other forms of preternatural phenomena, and yielded an epistemology of wonders intended to distinguish true from false prodigies and actual miracles from superstition as well as to redefine the limits of Nature. An enthusiastic scientific interest in marvels took root alongside the anxiety over diabolical deceits. Garzoni’s work addressed both the religious and scientific preoccupations. By analysing the "Serraglio" within the broader context of the European vernacular debate on marvels and superstitions, the GARZONI project will provide new insights into the circulation of scientific knowledge among non-specialist audiences, investigate the intermingling of learned culture and popular creeds and analyse the debate’s scientific and epistemological impact. The project will follow three main research directions: 1) the reconstruction of the editorial history of the "Serraglio"; 2) a study of its scientific sources; 3) the contextualization of the "Serraglio" within the coeval corpus of miscellaneous and encyclopaedic vernacular works on magic, divination and superstition. Dr Valentina Serio is a young researcher with international experience in the United States and the United Kingdom. Thanks to her past experiences as well as the knowledge and training she will receive during this GF at the University of Stanford, Warwick University and Ca’ Foscari, Serio will grow as a prominent scholar and significantly contribute to Renaissance intellectual history.

Keywords: history of wonders and curiosity superstition vernacular writing divination reformation and counter reformation church history learned and popular culture
Securing Tomorrow’s Digital Infrastructure with Quantum-Resistant Cryptography (Q-FENCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Luxembourg,Poland,Spain,United Kingdom,Austria,Romania,Germany,Switzerland
Call: Post-quantum cryptography transition (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 5312198.75
EU funding (EUR): 5312198.75
Participants: 15
Project status: SIGNED

Q-FENCE is a transformative initiative aimed at securing tomorrow’s digital infrastructure with quantum-resistant cryptography. In response to the rising threats posed by quantum computing, Q-FENCE develops a robust hybrid framework integrating classical, quantum, and post-quantum cryptographic techniques. Utilizing innovative approaches such as Ring-LWE, Module-LWE, Quantum Random Number Generators, and hardware-accelerated primitives, the project establishes a dual-layer security model that fortifies data protection across diverse infrastructures. Leveraging hardware-accelerated primitives and energy-efficient protocols, Q-FENCE ensures quantum resilience while addressing critical challenges such as seamless integration with legacy systems, regulatory compliance, and scalable deployment. By addressing key challenges like legacy system integration, interoperability, and regulatory compliance, it ensures a phased and seamless adoption across sectors including finance, healthcare, IoT, satellite and digital networks. Through sector-specific demonstrators, best-practice guidelines, and collaboration with EU policymakers, Q-FENCE bridges the gap between theoretical advancements and real-world applications, fostering digital sovereignty and resilience. Positioned as a critical player in the quantum-ready future, Q-FENCE not only safeguards sensitive data but also empowers stakeholders with practical, scalable, and innovative post-quantum solutions.

Keywords: hybrid cryptographic framework energy efficient cryptography hardware accelerated security secure multi party computation homomorphic encryption data privacy and integrity cybersecurity resilience
INtegrated Short-term PallIative REhabilitation to improve quality of life and equitable care access in incurable cancer (INSPIRE-HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 282493.75
EU funding (EUR): 282493.75
Participants: 2
Project status: SIGNED

The INSPIRE project aims to test the clinical and cost effectiveness of an innovative integrated short-term palliative rehabilitation intervention in people affected by incurable cancer. The current consortium includes partners from Western, Northern and Southern European countries. Involvement of the new proposed widening partner, Charles University in Prague, Czech Republic (CU), will enhance the goals of the project in three main ways: 1) expanding the trial to test the implementation and effectiveness of the INSPIRE intervention in conditions of a Central European healthcare setting in another part of Europe. 2) supporting wider comprehension and exploitation of the results of the project across European countries by involving the perspective of a Central European country into data collection, analysis, interpretation and dissemination activities 3) developing the reach and legacy of the project with new online educational tools (e-learning course and clinical toolkit) to support dissemination of the results of the project to current and future workforces. CU will be involved in 5 work packages with 3 specific additional tasks. In work package 7 (evidence synthesis and international consensus), the new partner will conduct a review of existing national clinical guidelines for rehabilitation in patients with palliative care needs. In work package 8 (dissemination and exploitation), CU will develop 2 online tools to support wider dissemination of the results. The first will be an online e-learning course for health care professionals to introduce the concept of the integrated INSPIRE intervention and its clinical and organizational use. The last specific task will be developing a clinical toolkit, presenting a set of practical handouts to be used in clinical practice. Expanding the consortium with the widening partner will support the overall ambition to make person-centred palliative rehabilitation into a routine part of the care for people with incurable cancer

Keywords: health policy and services,rehabilitation,palliative,quality of life,symptom management
Roles of G-quadruplexes in Kaposi’s sarcoma-associated herpesvirus latent REplication (G4-KuRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a widespread oncogenic virus, whose infection can cause Kaposi’s sarcoma, an incurable cancer frequent in immunocompromised individuals. Similar to other herpesviruses, KSHV establishes a latent infection in the host, characterized by lifelong persistence of the viral genome. Necessary and sufficient for latent infection are the virally expressed latency-associated nuclear antigen (LANA) and highly repetitive GC-rich sequences on the viral genome, named terminal repeats (TRs). While several studies have uncovered the importance of LANA in promoting KSHV DNA replication and segregation during latency, the essential role of the TRs remains poorly understood. In particular, the GC-rich regions contained in the TRs have been speculated to fold into G-quadruplexes (G4), secondary DNA structures that can function as replication barriers, but their roles remain elusive. A deep mechanistic understanding of the ways KSHV maintains itself in latency would be crucial to uncover a way to eradicate the virus from the infected cells, before the onset of Kaposi’s sarcoma, but this knowledge is missing, mainly due to the methodological limitations of investigating KSHV latent replication solely in cells. With this proposal, in aim to take advantage of the Xenopus laevis egg extract in vitro system to go beyond such limitations and to gain mechanistic insight in the role of G4s in the latency of KSHV. By combining my extensive expertise in the field of DNA replication with the deep knowledge of Prof. Sara Richter at the University of Padua in secondary DNA structures in viral genomes, I aim at mechanistically defining the strategies adopted by KSHV to maintain itself in latency and at identifying approaches to prevent viral maintenance in KSHV infected cells. The proposed project will have great societal impact on cancer prevention, and it will be pivotal for my scientific and personal growth into an independent junior group leader.

Keywords: g quadruplexes,xenopus egg extracts,oncogenic herpesviruses,mass spectrometry
Scaling Up Research in SSA Countries in Infectious Diseases: African-European Training Network in Integrated Health Informatics and Data Sciences (BRIDGE NETWORK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Belgium,Rwanda,Kenya,South Africa,Benin,Ethiopia,Norway,Uganda
Call: Global Health EDCTP3 Training Networks - Clinical Research Fellowships (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-10-01
End date: 2029-03-31
Duration (months): 54.0
Total project cost (EUR): 4999200.0
EU funding (EUR): 4999200.0
Participants: 12
Project status: SIGNED

An African-European consortium of 6 SSA countries and 3 European countries, gathering 12 partners is proposing a unique and innovative scalable training program and network that will produce empowered infectious diseases experts to lead and drive research from and for sub-Sahara Africa (SSA), at levels of early-stage career (post-graduate certification and doctoral) and mid-stage career (post-doctoral) in an integrated program of health informatics and data sciences (BRIDGE PROGRAM). The program consortium will set up 5 Centre of Excellence (CoEs) in SSA countries (Benin, Ethiopia, Uganda, Kenya, Rwanda and South Africa). The CoEs will serve as training setting, field research setting and a hub for harmonized infectious diseases data, and all will recruit candidates from their countries for certification program, doctoral and post-doctoral fellowships but only 3 CoEs will be the degree awarding institutions. The degree awarding CoEs have been selected based on the existing university capacity to offer a degree awarding program or built on the existing partnerships between selected SSA public health institutes and local universities with degree awarding programs capacity. The program leverages the established collaborations between European and SSA institutions, utilizing accumulated medical data, including Electronic Health Records, registries, and biobanks. At the end of 54 months, program will have strengthened the institutional research leading capacities with at least 20 trainees per CoE with post-graduate certification, a total of 10 graduates with PhDs and a total of 4 post-doctoral fellows, skilled for harmonizing and analysing fragmented large data to derive data-driven insights and guide health policies. The CoEs embedded within public health institutions, with continuous mentorship from an international scientific community and a ready to use large amount of data, ensure the sustainability of training and collaborative research beyond the program grant.

Keywords: sub sahara africa ssa,data sciences,health informatics,digitalisation,electronic health records ehrs
Linguistic and acoustic properties of infant-directed speech in Hindi-learning infant’s (Hindi-BabyNet) (Hindi-BabyNet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,India
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: SIGNED

Recently it showed that the research in infant language acquisition is highly skewed towards English and other well-studied Indo-European languages. Therefore, most of the evidence regarding IDS helps in infant's language development stems from the families living in WEIRD (Western, Educated, Industrialized, Rich, and Democratic) countries (like the U.K., US, Germany, France etc.). Yet, we know that parent’s communication with their infants varies across cultures regarding their gestures, vocal emotions, and speech. Because of these differences in parent-infant interaction, infant language learning in WEIRD countries/societies can be assumed to differ from contemporary infant learning in the developing world. Consequently, we cannot ascertain whether the contrast of IDS with ADS and its tailoring to infants' language development found in WEIRD countries/societies can be generalized to non-WEIRD countries/societies. Hence, to generalize the impact of IDS on infants' language development, empirical investigations are required in contemporary developing societies like India, which show what life has been like for most infants in the developing world. The 'Linguistic and acoustic properties of infant-directed speech in Hindi-learning infant’s (Hindi-BabyNet) project will provide a unique opportunity to gain better insights into infant language acquisition in India across various socio-economic backgrounds. This study aim to provide CDI norms for Hindi-speaking group. Also, this study includes collecting infant and adult-directed speech data for Hindi speakers across different social-economic statuses in India. In addition, this study aims to find the acoustic features of infant-directed speech and their significance in early language development from an Indian perspective and also utilize machine learning model to investigate the acoustic cues of IDS that are useful in learning mechanism.

Keywords: communicative development inventories cdis,infant s language development,infant directed speech,adult directed speech,acoustics,vowels,phonemes,pitch,formants