Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
THOR – Technical and Human Infrastructure for Open Research (THOR)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Australia,Germany,Belgium,Switzerland,United States,Netherlands,United Kingdom
Call: Provision of core services across e-infrastructures (H2020-EINFRA-2014-2, 2014)
Start date: 2015-06-01
End date: 2017-11-30
Duration (months): 30.0
Total project cost (EUR): 3458250.0
EU funding (EUR): 3456250.0
Participants: 10
Project status: CLOSED

Five years ago, a global infrastructure to uniquely attribute to researchers their scientific artefacts (articles, data, software…) appeared technically and socially infeasible. Since then, DataCite has minted over 3.5m unique identifiers for data. ORCID has deployed an open solution for identification of contributors with over 850,000 registrants in less than 2 years. THOR will leverage these emerging global infrastructures to support the H2020 goal to make every researcher ‘digital’ and increase creativity and efficiency of research, while bridging the R&D divide between developed and less-developed regions. We will establish interoperability between existing resources, linking digital identifiers across platforms and propagating attribution information. We will integrate PID services across the research lifecycle and data publishing workflows in four advanced research communities, and then roll-out core services and service building blocks for the wider community. These open resources will foster an open and sustainable e-infrastructure across stakeholders to avoid duplications, give economies of scale, richness of services and the ability to respond rapidly to opportunities for innovation. THOR is not just relevant to the EINFRA-7-1024 Call, but will become a pervasive element of the EINFRA family of e-Infrastructure resources over the next 3 years. It will allow data-management and curation services to exploit knowledge of data location and attribution; provide robust and persistent mechanism for linking literature and data; enable search and resolving services and generate incentives for Open Science; deliver provenance and attribution mechanisms to underpin data exchange; and provide minting and resolving services for data citation workflows. Its impact will enable third-party services, no-profit and commercial, to leverage the scholarly record.

Keywords: persistent identifiers,core services,e infrastructure,open data pilot,open science,research data,researcher identifiers,research infrastructure,scholarly communication,digital science
Development of a fuel flexible and highly efficient ultra low emission residential-scale boiler with coupled heat recuperation based on flue gas condensation (FlexiFuel-CHX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Austria,Germany,Austria,Switzerland,Netherlands
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2015-1-two-stage, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 4309610.0
EU funding (EUR): 3514397.5
Participants: 7
Project status: CLOSED

The project aims at the development of a new fuel flexible and highly efficient residential biomass heating technology (20 - 130 kW). It is based on the successful UleWIN wood chip and pellet boiler concept consisting of a fixed-bed updraft gasifier directly coupled with a Low-NOx gas burner and a hot water boiler, which shall be further developed for fuel flexible operation (utilisation of forest residues, SRF, miscanthus, olive stones, nut shells and agro-pellets). Moreover, a compact flue gas condensation system with integrated condensate neutralisation, also capable to operate with highly acidic flue gases from agricultural fuel combustion, shall be developed to increase the efficiency of the whole system up to 110% (related to the fuel NCV). An advanced control system as well as measures for improved system integration shall additionally increase the annual utilisation rate up to 95%. It is expected to achieve at the end of the project a TRL of 5. These objectives are very relevant to the work programme since they focus on highly efficient and fuel flexible residential heat production at almost zero CO and OGC emissions, by 50% reduced NOx emissions (compared with conventional boilers) as well as ultra-low PM emissions below 13 mg/MJ (even when utilising K-rich fuels). Since this shall be reached by primary measures only, fuel flexible heat generation will be possible at reduced heat generation costs in comparison to present heating systems. To fulfil these goals an overall methodology shall be applied which is divided into a technology development part (based on process simulations, computer aided design of the single units, test plant construction, performance and evaluation of test runs) as well as a technology assessment part covering risk, techno-economic, environmental and overall impact assessments, market studies regarding the possible potentials for application of the new technology as well as dissemination activities.

Keywords: biomass,condensing boiler,fuel flexibility,updraft gasifier,ultra low emissions
Personal Ornaments in the Palaeolithic of Europe (PeOPLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The project PeOPLE (Personal Ornaments in the PalaeoLithic of Europe) seeks a new perspective on the archaeological framework for Eastern Europe during the earlier part of the Upper Palaeolithic (UP) by study of the beads and other personal ornaments known from sites of this period. The study period covers ca. 45,000-25,000 years ago – the first twenty thousand years of modern human occupation of ice age Europe. Our knowledge of cultural change and variation in the UP is based heavily on lithic artefacts: stone tools and the waste from their production. There are numerous shortcomings in our present understanding of Palaeolithic cultural variation, especially in Eastern Europe. Personal ornaments, which have been found in large numbers at sites of this period, represent an underused resource for understanding UP cultural diversity and connections in this region. The known corpus of these artefacts will be studied based on published sources and by direct examination of selected collections using established techniques. Attributes of the artefacts themselves and of their archaeological contexts will be recorded. A database will be produced which will be analysed using statistical techniques, including some borrowed from genetics. The results of the analysis will be compared with the current archaeological framework for this period and, where possible, with genetic trees based on aDNA studies. The project offers great scope for testing and refining our current understanding of cultural variation and change during this period. It will also provide an excellent test-case for some theoretical anthropological questions, regarding e.g. human responses to climate change and the spread and persistence of material culture traditions. Communication and outreach is an important part of this project. This will include the creation of open-access resources, including 3D scans of artefacts where possible, and targeted outreach activities.

Keywords: palaeolithic,upper palaeolithic,russia,personal ornaments,archaeological cultures,culture history,chronology,lithic analysis,aurignacian,gravettian,streletskian,gorodtsovian
European Regulatory Science on Tobacco:Policy implementation to reduce lung diseases (EUREST-PLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Switzerland,Hungary,Romania,Greece,Greece,Belgium,Poland,Netherlands,United Kingdom,Canada
Call: Global Alliance for Chronic Diseases. Prevention and treatment of lung diseases (H2020-HCO-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 2709295.0
EU funding (EUR): 2325545.0
Participants: 13
Project status: CLOSED

Smoking and other forms of tobacco consumption are considered the single most important cause of preventable morbidity and premature mortality worldwide. Efforts to reduce the devastation of tobacco-related deaths and illness in the EU consist of the Tobacco Products Directive (TPD), and the ongoing implementation of the WHO Framework Convention on Tobacco Control (FCTC). The main objective of EUREST-PLUS is to monitor and evaluate the impact of the TPD within the context of FCTC ratification at an EU level. Our 4 specific objectives hence are: 1) To evaluate the psychosocial and behavioral impact of TPD implementation and FCTC implementation, through the creation of a longitudinal cohort of adult smokers in 6 EU MS (Germany, Greece, Hungary, Poland, Romania, Spain; total n=6000) in a pre- vs. post-TPD study design. 2) To assess support for TPD implementation through secondary dataset analyses of the Special Eurobarometer on Tobacco Surveys (SETS), cross-sectional surveys performed among 27,000 adults in all 28 EU MS, before the TPD is implemented and to monitor progress in FCTC implementation in the EU over the past years through trend analyses on the merged datasets of the 2009, 2012 and 2015 SETS datasets (n=80,000). 3) To document changes in e-cigarette product parameters (technical design, labelling/packaging and chemical composition) following implementation of Article 20 of the TPD. 4) To enhance innovative joint research collaborations, through the pooling and comparisons across both other EU countries of the ITC Project (UK, NL, FR), and other non-EU countries . Tackling tobacco use is quintessential to reducing the impact of chronic NCDs, a topic EUREST-PLUS will stride to lead.

Keywords: tobacco products,tobacco products directive,fctc,policy implementation
Towards the prevention of aminoglycoside antibiotic-related deafness (DesignerAntibiotics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-13
End date: 2020-02-12
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

Aminoglycosides are critically important antimicrobials used in the treatment of life-threatening infections. A major drawback of usage is hearing loss caused by irreversible damage to the inner ear (ototoxicity). Ototoxicity occurs in ~20% of patients and ~100% of patients with the m.1555A>G mitochondrial DNA mutation. The largest EU patient group exposed to aminoglycosides are children in neonatal intensive care and the effect of hearing loss during infancy is particularly profound as it impedes language acquisition. Thus, there is an urgent need to develop safer aminoglycoside antibiotics. Ototoxicity limits usage despite the antibacterial potency and low incidence of drug resistance provided by this class of antibiotics. Economically, the annual EU cost incurred by drug resistant infections amounts to €1.5 billion, and the cost of hearing impairment is estimated to be €78 billion. Moreover, 25,000 EU patients die annually as a result of infections caused by resistant bacteria and 22.5 million suffer from hearing impairment, with 2 million profoundly deaf. Stanford research recently published in the Journal of Clinical Investigation has shown that it is possible to chemically modify aminoglycosides to diminish ototoxicity while maintaining antibacterial activity. Through a novel collaboration between Stanford and University College London (UCL), the aim of this research is to use a results-guided drug design approach to develop the next generation of safer aminoglycoside antibiotics. For this work, the candidate will have access to 15 novel patented aminoglycoside compounds, crystallography data, murine in vitro and in vitro models of ototoxicity, and a rare biobank of cells from patients with the m.1555A>G mutation. This work will build upon the candidate’s Distinction Masters of Research structural biology experience at Imperial College London, and UCL PhD and recent first-author publication in Human Molecular Genetics related to aminoglycoside ototoxicity.

Keywords: deafness,hearing loss,m 1555a g,aminoglycoside antibiotics,ototoxicity,drug development
The lexical semantics of lexical categories (LexsemLexcat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1993869.0
EU funding (EUR): 1993869.0
Participants: 1
Project status: SIGNED

The distinction between the major lexical categories of noun, verb and adjective figures into myriad linguistic generalizations and has been a center of gravity in the study of language since antiquity. Notwithstanding their importance, lexical categories are poorly understood (see e.g., Baker & Croft 2017). Outstanding is whether there are generalizations about the meanings words in the major categories have. Many have claimed there are, and proposed theories linking meaning and category, in a one to one fashion. Such theories have been criticized, however, in light of clear counterexamples, and consequently the search for a universal link between meaning and category is perceived by many to have been unsuccessful (see von Fintel & Matthewson 2008). This project recasts the search for a link, in the spirit of recent work (Francez & Koontz-Garboden 2017: Chapter 5), not as one for a one-to-one mapping, but for constraints on meaning induced by category. The project targets a domain where the set of relevant meanings is small, but where there is variation in category: property concept sentences—sentences like (1) He is very clever, whose main predicate is an adjective or, (2) akwai shi da waayoo `He is very clever (lit: He exists with cleverness; Hausa; Newman 2000:179)', whose main predicate is not an adjective, but is translated by a sentence whose main predicate is an adjective in languages with a large class of them. Although (1) and (2) have the same meaning, their component parts do not. Recent work shows that the words in property concept sentences that introduce the descriptive content (clever in (1), waayoo (2))--property concept words--vary in meaning, not just in category (Dixon 1982). With three postdocs, this project draws on a 200 language typological survey and in-depth fieldwork to examine the crossclassification of meaning and category in property concept words to shed light on the semantic nature of nouns, verbs, and adjectives generally.

Keywords: formal semantics,lexical categories,adjectives,property concepts
eXTENDing the energy performance assessment and certification schemes via a mOdular approach (X-tendo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Italy,Austria,Romania,Belgium,Belgium,Greece,Poland,Portugal,Denmark,United Kingdom
Call: Next-generation of Energy Performance Assessment and Certification (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 2057277.5
EU funding (EUR): 2057277.5
Participants: 13
Project status: CLOSED

X-tendo will support public authorities to transition to next-generation energy performance certification (EPC) schemes, including improved compliance, reliability, usability and convergence. The key output of the project will be the X-tendo toolbox, a freely available online knowledge hub that will be continued also beyond the project duration. It will contain 10 innovative EPC features ranging from a smartness and a comfort indicator to building logbooks and how to improve EPC databases. For each feature the toolbox will include: (1) solution concepts and good practice examples, (2) description of methodological approaches, (3) calculation tools, and (4) implementation guidelines and recommendations. A selection of twenty-nine test projects in nine different member states will demonstrate the potential of each feature as part of more reliable next-generation EPC schemes across the EU. Intensive stakeholder engagement, experience exchange activities, continuous dissemination and an ambitious exploitation strategy will maximize X-tendo’s impact across the EU. Direct impact on (future) policy making will be achieved by (1) understanding end-users and their needs, (2) engaging with public bodies covering at least 75% of the EU building stock, (3) close collaboration between policy makers and technical, communication and financial experts, (4) outreach to EU-wide initiatives such as the Concerted Action on the EPBD and the European Energy Network, and (5) assessing the viability of policy implementation. Improved and next-generation EPC schemes and the innovative handling and use of EPC-related data will push the market towards better performing buildings and facilitate the interaction between building owners, the construction industry and the finance sector. The combination of the expertise of the project partners and the actions and outputs of the project will steer EPC schemes across Europe to the next-generation requirements.

Keywords: buildings energy performance,assessment,certification
Overcoming the Selectivity Challenge in Chemistry and Chemical Biology via Innovative Tethering Strategies (SeleCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In the last two centuries, synthetic organic chemistry has undergone an unprecedented revolution. The ability to understand and modify the molecular structure of matter has changed our life in many areas, such as medicine, agriculture or commodity materials. These major successes gave the impression that synthetic chemistry is a mature field. However, this impression is completely misleading, as current synthetic methods still lack the selectivity needed for the modification of complex molecules. Both selecting between different reactive groups and functionalizing inert bonds in their presence represent formidable challenges. In this project, we propose to develop highly selective “molecular tethers” for the functionalization of both natural/synthetic organic compounds and biomolecules. The envisioned tethers are bifunctional small organic molecules having three fundamental properties: 1) A “biting end” with unique reactivity to be selectively installed in situ onto naturally occurring thiols, alcohols and amines. We will use tethers based on acetals and hypervalent iodine reagents. 2) A “functional end”, whose reactivity can be revealed “at will” to functionalize bonds that cannot be accessed with the current state of the art of synthetic chemistry, especially inert C-H and C=C bonds. 3) Being traceless, meaning that they can be removed easily once the desired functionalization has been achieved. The main impact of this project will be in fundamental synthetic organic chemistry, as it will contribute to overcoming major selectivity hurdles in the functionalization of complex molecules. It will therefore result in faster progress in all the fields depending on synthetic molecules, such as medicine, agriculture or materials. A more efficient functionalization of biomolecules will allow us to soften the boundaries between synthetic chemistry and biology, leading to major progress in our understanding of living systems and our ability to modify them.

Keywords: late stage functionalization,new synthetic methods,c h bond and olefin functionalization,biomolecule functionalization,radicals,photoredox,selectivity,covalent linkers,hypervalent iodine