Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transformational and Robust AdaptatioN to water Scarcity and ClimatE chaNge under Deep uncertainty (TRANSCEND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Italy,Sweden,Austria,Spain,Lebanon,Greece,Slovakia,India,United States,United Kingdom
Call: Climate sensitive water allocation systems and economic instruments. (HORIZON-CL6-2022-CLIMATE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4474768.75
EU funding (EUR): 4331088.0
Participants: 16
Project status: SIGNED

Worldwide, water resources management is increasingly challenged by water scarcity and climate change, which can trigger and aggravate other ecological (e.g. pests) and socioeconomic threats (e.g. commodity price fluctuations) via feedback loops and cascading impacts across systems. In this context, planning for the future is rife with uncertainties for which conventional decision-making methods and policies are inadequate. The objective of TRANSCEND is to identify and catalyze the adoption of Transformational Adaptation Policies (TAP) to water scarcity, including innovative allocation systems and economic instruments, that are robust and adaptable to uncertainty and change, while simultaneously achieving equitable and sustainable economic growth and welfare. To this end, TRANSCEND will develop a groundbreaking ecosystem of innovation that combines three key pillars: (i) a knowledge network for stakeholder engagement and knowledge sharing, (ii) an actionable modeling suite that integrates interdisciplinary socio-ecological science and ensemble forecasting to guide TAP design, and (iii) an accounting and monitoring toolbox that supports implementation and enforcement of TAP in practice. TRANSCEND will apply the ecosystem of innovation to design and implement TAP in 7 labs: Júcar River Basin (RB) (Spain); Reno RB (Italy); Tympaki RB (Greece); Nitra RB (Slovakia); Caplina-Mauri-Desaguadero RB (Peru, Chile & Bolivia); Orontes RB (Lebanon, Syria & Turkey); and Mahanadi RB (Indian states of Chhattisgarh & Odisha). TRANSCEND will leverage this diverse set of demonstrators to initiate adoption of the ecosystem of innovation in 8+ inspiration labs, train 160+ transformation agents, and mainstream uncertainty analysis in key national and European Green Deal strategies. This will provide the knowledge and tools to catalyze robust and systemic transformations to water scarcity and climate change globally, with a clear impact pathway towards TAP adoption in 100+ basins by 2030.

Keywords: transformational adaptation,uncertainty,economic instruments,water allocation,climate change,water scarcity
Contribution of tRNA fragments in the ETiopathogenesis of Huntington's Disease (tR-GET HD) (tR-GET HD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-15
End date: 2025-03-14
Duration (months): 29.0
Total project cost (EUR): 188121.81
EU funding (EUR): 188121.81
Participants: 1
Project status: SIGNED

Many pathogenic mechanisms are involved in Huntington’s disease (HD), the most prevalent monogenic neurological disease in Europe, with no current cure. The host team reported a dysregulation of tRNA-fragments (tRFs) in HD brains; other studies showed higher stress granules' (SG) density in HD, and that tRFs promote SG assembly. Thus, my hypothesis is that HD-related tRFs contribute to the accumulation of SG, initiating mutant huntingtin (mtHTT) aggregation and leading to disease pathogenesis. I propose to explore the interaction between mtHTT aggregates, and tRFs and SG, as new potential therapeutic targets. Specifically, I aim to study the 1) cell-type specificity of tRFs formation and their correlation with HD progression; 2) molecular mechanisms by which tRFs may induce HD pathology; and 3) potential of tRFs modulators to treat mtHTT-related neurotoxicity. This project’s success relies on the perfect synergy of the host team’s expertise in tRFs biology and HD and my own experience in RNA and proteotoxicity in neurodegenerative diseases, thoroughly addressing the hypothesis via complementary human, cellular and mice HD models and a plural array of bioinformatic, molecular biology and genomic approaches. The outcomes will help define the role of tRFs and SG in mtHTT aggregation, and may be used as preclinical proof-of-concept for novel HD therapies, reflecting the project’s translational potential. I will benefit from scientific exchanges with expert neuroscientists in the host institution, particularly my supervisor, whose skills in functional genomics fully match my expertise in RNA and protein pathological mechanisms. My translational technical knowledge and network of collaborators will be useful to the host group to build new cooperative projects. Thus, the MSCA fellowships will allow me to develop unique technical and transferable skills, helping me progress and establish myself as a leader in neurodegenerative research within a European research institute.

Keywords: huntington s disease,trna,trna derived fragments trfs,stress granules,huntingtin protein aggregation,neurotoxicity,pathogenic mechanisms,therapeutic potential,protein translation
Controlled irrigation technology scale-up in high potential farming segments. (ControlledScaleUp)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Netherlands
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Agurotech B.V. is an Amsterdam based deep-tech start-up that focuses on smart farming solutions for the global agriculture industry. The company was founded in November 2020 as a spin-off from the Dutch institute of subatomic physics and is founded, operated and owned by 2 females with majority share (85%) of the company. Agurotech B.V. develops IoT-based hardware (sensors) and AI-powered software solutions to perform measurements in farmers' fields and uses advanced algorithms to translate these measurements into meaningful insights and actionable recommendations. These solutions help farmers to increase their yield, while using their resources more effectively. It has been shown that over 20% of yield can be increased and resources can be reduced anywhere between 30-80%. This is important because the farming industry has a significant role in today's societal sustainability challenges, such as carbon emissions, water scarcity and soil health. It is recognized that precision farming technology will play a key role in addressing these challenges. Given that Agurotech is a deep-tech start-up, until now, significant focus has been on R&D and product development. The company has just started commercialization and is increasing the customer base and preparing for scale up. Agurotech identified target segments who benefit most from Agurotech’s products and services, these include: flower bulbs, potatoes, onions, carrots and sugar beets. Agurotech’s strategy is to offer products and services in selected niche segments before expanding to other segments. The goal of the project that is presented in this proposal is to start penetrating the flower bulbs and onions segment in order to 1. Validate the potential of these segments 2. Realize a better product-market fit and 3. Start realizing sales in these segments. If granted: this project will be used to realize a controlled and fact-driven scale up of sales of Agurotech’s products and services in selected segments.

Keywords: software,high tech sensor technology,irrigation,climate change,ai machine learning
CARABELA-NF1: CDK4/6i Resistance and Biomarker Analysis in Neoadjuvant settings from CARABELA trial. (CARABELA-NF1)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

HR+/HER2- breast cancer (BC) patients often show limited response to current neoadjuvant chemotherapy, highlighting the critical need for alternative therapeutics strategies. The combination of CDK4/6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard of care in adjuvant treatment for HR+/HER2- BC, with the potential for significantly improved outcomes in the neoadjuvant setting. However, drug resistance remains a significant challenge, with a critical need for early-stage biomarkers to predict resistance. The CARABELA phase 2 clinical trial, led by Dr. Emilio Alba (the supervisor of this proposal), provides valuable data on the efficacy and resistance patterns of prolonged CDK4/6i plus ET in neoadjuvant settings. Previous research by Dr. Chica-Parrado (the candidate) identified NF1 loss-of-function (LOF) mutations as key drivers of resistance to both ET and CDK4/6i. The CARABELA-NF1 study aims to leverage this expertise to integrate preclinical data with clinical insights from the CARABELA trial. The objectives of CARABELA-NF1 project are: (1) To perform targeted sequencing of circulating tumor DNA (ctDNA) to identify genomic alterations associated with resistance to CDK4/6i or ET and correlate these with clinical responses. (2) To develop an NF1-loss signature (NF1sig) from cell line data and validate this predictive signature using RNA from pre-treatment samples in the CARABELA trial. (3) To conduct drug screening in HR+/HER2- BC organoids derived from patients resistant to ET and CDK4/6i with NF1 mutations, focusing on the activation of pathways induced by the treatment. This project combines advanced genomic profiling with clinical trial data and drug screening to address the pressing need for effective biomarkers and novel therapeutic strategies in the neoadjuvant setting for HR+/HER2- BC.

Keywords: hr breast cancer,neoadjuvant therapy,cdk4 6 inhibitors,predictive panels,resistance mechanisms,circulating tumor dna ctdna
TechConnect: Assessing and Strengthening Human-Tech Skill Complementarity in the Digital Landscape (TechConnect)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Ireland,Greece
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 36.0
Total project cost (EUR): 367222.5
EU funding (EUR): 367222.5
Participants: 2
Project status: CLOSED

TechConnect thoroughly explores the ongoing debate regarding the influence of emerging technologies on human labor and skills. It places a distinct emphasis on Human-Tech Skill Complementarity, highlighting the essential interdependence and mutual enhancement of both human and technological skills in a systemic manner. The primary goal is to deepen our understanding of the dynamic interplays between new digital technologies and human skills, generating novel and practical knowledge on this emerging topic of Human-Tech Skill Complementarity. The project brings together a multidisciplinary team and employs diverse methods, including policy analysis, systematic literature review, annual cross-sectoral industry landscape surveys, in-depth case studies in the healthcare sector and validating the findings beyond this sector via stakeholder engagement, workshops, and guidelines production. The key outcomes include the development and validation of the Human-Tech Skill Complementarity Conceptual Framework, Assessment Index, Strengthening Model, and TechConnect Stakeholder Toolkit. These outcomes reveal the how new technologies such as AI and robotics affect human skills, emphasising the development and deployment of technologies that enhance individual skills and workforce capabilities. Adopting a collaborative approach, TechConnect forms a consortium with academics, industry partners, and a stakeholder engagement firm. This collaborative effort fosters partnerships with technology associations, professional groups, and government entities. Grounded in the research-informed, evidence-based and practice-driven approaches, TechConnect will make a meaningful impact on the quality of employment and competitiveness, contributing to social and economic resilience. The collective efforts of the consortium are geared towards disseminating findings and recommendations widely, with the ultimate goal of influencing policy and practice for inclusive growth in the digital landscape.

Keywords: educational policy life long learning human tech skill complementarity conceptual framework assessment index strengthening model driving changes scaling job quality improved work conditions
Dynamic coil-shaped polylactic acid-reinforced extracellular matrix-derived scaffold with oriented pores for articular cartilage tissue engineering (RECoil3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-07-31
Duration (months): 28.0
Total project cost (EUR): 185644.48
EU funding (EUR): 185644.48
Participants: 1
Project status: SIGNED

Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC can cause underlying bone damage creating an osteochondral (OC) defect. OC defects cause pain, impaired mobility and can develop to Osteoarthritis (OA). OA is the most common form of arthritis, affecting nearly 10% of the population worldwide, and a serious disease representing a significant economic burden to patients and society. In Europe, the cost of OA per patient is estimated to exceed € 10,000 per year. At present, the treatment options for OA are limited to surgical replacement of the diseased joint with a prosthesis. While this procedure is well established, it is not without its limitations, and failures are not uncommon. In addition, joint replacement prostheses have a finite lifespan, making them unsuitable for the growing population of younger and more active patients requiring treatment for OA. While significant progress has been made in this field, realising an efficacious therapeutic option for the treatment of unresolved OA remains elusive and is considered to be one of the greatest challenges in the field of orthopaedic regenerative medicine. One of the critical problems when repairing OC defects is the poor repair of the AC due to its repair with a low-quality scarring tissue, lacking the native aligned collagen microarchitecture. Therefore, there is a societal need to develop new strategies for AC regeneration. The RECoil3D project aims to develop a new generation of dynamic load-bearing implants based on the Reinforcement of an extracellular matrix (ECM)-derived scaffold containing an aligned pore architecture with a dynamic Coil-shaped 3D printed polylactic acid (PLA) constructs for AC tissue repair.

Keywords: freeze drying,3d printing,meta materials
Entrepreneurial & Innovative Universities Acceleration Programme (Accelerate_FutureHEI)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Netherlands,Hungary,Romania,Latvia,Germany,Ireland,Portugal,France,Spain,Austria,Belgium
Call: Acceleration Services in support of the institutional transformation of Higher Education Institutions (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3197063.75
EU funding (EUR): 3197063.75
Participants: 12
Project status: SIGNED

Higher Education Institutions (HEIs) can have a strong positive impact on regional and Europe-wide social and economic development through education, research and engagement. However, they require targeted, methodological and experienced support to enhance their capability to fully realise their potential. Accelerate_FutureHEI responds to the above-mentioned needs through the development and testing of acceleration services to support HEI institutional transformation involving: - A robust, comprehensive methodology that is designed to transform and impact not just the HEIs but also their regions. It does so by taking an evidence-based approach that identifies the needs of the individual HEIs whilst also benefitting from an efficient universal approach that enables them to learn from each other. - Underpinned by a change management process, the project offers an acceleration support system that builds on the status quo, develops a connected vision and set of activities described in a roadmap and is then executed in application projects supported with coaching, training and international exchange. - Consortium built for success and impact as the project and overall methodology for acceleration services is designed, led and monitored by proven, globally-recognised experts specialised in implementing acceleration services to effect change at HEIs through entrepreneurship, innovation and engagement. - The consortium offers the right setting for a pilot program to deliver a meaningful context-connected, practical outcomes for a committed and diversified set of 14 partners, uniting 2 established EIT HEI Initiative consortia, where impact would make a real difference in their regions. - Sustained impact will be achieved as HEIs will have developed strong internal understanding of status quo and desired future state; designed and executed a roadmap & application projects; received expert coaching, training and peer learning in a network that will sustain beyond the project timeline

Keywords: entrepreneurial and innovative university,hei transformation,cultural change,regional innovaion ecosystems,regional engagement
Evolution of leaf shape diversity in Angiosperms using single cell approaches (LeafMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-07-31
Duration (months): 25.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

Leaves show a large scale of morphological diversity. Advanced time-lapse imaging and computational analysis revealed specific growth differences underlying development of different leaf forms in the simple leaves of A. thaliana vs the complex leaves of its relative C. hirsuta. However, this does not capture the differences in genetic networks that underlie these growth changes during development. To solve this problem, I will apply state-of-the-art single cell technologies to dissect the genetic networks behind leaf development and complexity. First, by utilizing multimodal single cell sequencing technologies in high temporal resolution, I will describe the cell-type specific gene regulatory networks (GRNs) during leaf development. By comparing these cell types and GRNs between A. thaliana and C. hirsuta we will be able to make major steps on understanding mechanisms underlying development and diversity of leaf forms. To understand how the newly discovered GRNs interact in a developing tissue context I will apply spatial transcriptomics to understand how local genetic changes can influence morphogenesis. To analyze this, I will implement a novel functionality in a software, MorhoGraphX, which was originally developed for microscopy-based growth analysis. This way, it will be possible to directly link the genetic regulators to cellular morphological properties. A selected number of these regulators will be further investigated with comparative genetic methods empowered by gene editing.To further extend the findings and place them into a broader evolutionary perspective, I will investigate cell type specific GRNs in two Solanaceae species, one with simple (pepper) and one with complex leaves (tomato).By comparing the commonalities and differences between simple and complex leaves in Brassicaceae and Solanaceae, which occurred independently during evolution, we can reveal developmental and evolutionary constrains underlying differences between simple and complex leaf.

Keywords: leaf complexity,evolution,development,single cell,spatial transcriptomics,multiomics,comparative genetics