Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BiogENesis and Degradation of Endoplasmic Reticulum proteins (BENDER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2022-06-30
Duration (months): 63.0
Total project cost (EUR): 2496611.0
EU funding (EUR): 2496611.0
Participants: 1
Project status: CLOSED

The Endoplasmic Reticulum (ER) membrane in all eukaryotic cells has an intricate protein network that facilitates protein biogene-sis and homeostasis. The molecular complexity and sophisticated regulation of this machinery favours study-ing it in its native microenvironment by novel approaches. Cryo-electron tomography (CET) allows 3D im-aging of membrane-associated complexes in their native surrounding. Computational analysis of many sub-tomograms depicting the same type of macromolecule, a technology I pioneered, provides subnanometer resolution insights into different conformations of native complexes. I propose to leverage CET of cellular and cell-free systems to reveal the molecular details of ER protein bio-genesis and homeostasis. In detail, I will study: (a) The structure of the ER translocon, the dynamic gateway for import of nascent proteins into the ER and their maturation. The largest component is the oligosaccharyl transferase complex. (b) Cotranslational ER import, N-glycosylation, chaperone-mediated stabilization and folding as well as oligomerization of established model substrate such a major histocompatibility complex (MHC) class I and II complexes. (c) The degradation of misfolded ER-residing proteins by the cytosolic 26S proteasome using cytomegalovirus-induced depletion of MHC class I as a model system. (d) The structural changes of the ER-bound translation machinery upon ER stress through IRE1-mediated degradation of mRNA that is specific for ER-targeted proteins. (e) The improved ‘in silico purification’ of different states of native macromolecules by maximum likelihood subtomogram classification and its application to a-d. This project will be the blueprint for a new approach to structural biology of membrane-associated processes. It will contribute to our mechanistic understanding of viral immune evasion and glycosylation disorders as well as numerous diseases involving chronic ER stress including diabetes and neurodegenerative diseases.

Keywords: cryo electron tomography,endoplasmic reticulum,er translocon
EXOsomes as a new strategy in Assisted Reproductive Technologies: tracing maternal nanomessengers to improve pregnancy outcomes (EXORep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The current embryo in vitro culture conditions used in most laboratories of assisted reproductive technologies (ARTs) allow the embryo to develop to the blastocyst stage and to achieve pregnancy. However, the quality of those embryos is suboptimal compared to the in vivo ones and the obtained pregnancy rates are low. The lack of maternal signals, during the in vitro period has been postulated as a main reason for these suboptimal results. There is increasing evidence of the role of the oviduct exosomes (oEXs) as mediators of the early maternal-cross talk. Recent data revealed the first oviduct-derived EXs protein signature and their important roles in embryo-oviduct interactions. In the present proposal, using bovine model, we aimed to: (i) Evaluate whether the presence of the early embryo in the oviduct could modulate the oEXs proteins, mRNA and miRNA content depending on its stage of development. (ii) Assess whether the embryo quality (good or poor embryo) affect the content of EXs secreted in vitro by the oviduct epithelial cells. (ii) Assess the effect of in vitro culture with oEXs on the embryo development and quality. To accomplish these tasks, an ambitious, realistic, work plan has been designed based on the excellent background of the Fellow, and the training she will receive, the expertise of the supervisor in female reproductive physiology and the infrastructure within the host lab for conducing all the experiments with most appropriate tools. This will ensure that the Fellow completes the scientific objectives of the proposal, communicate and disseminate the results to the scientific and public, while acquiring new set of skills that will have an important impact in her career development. If the beneficial effect of oEXs on embryo development is recapitulated in cattle, it could improve in vitro embryo production largely used in ART in dairy cattle industries. Moreover, the obtained results may be transferred in human species

Keywords: oviduct embryo crosstalk,exosomes,cattle fertility
Space-borne observations for detecting and forecasting sea ice cover extremes (SPICES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Germany,Italy,Türkiye,Norway,Norway,Finland,France,Denmark,Denmark,United Kingdom
Call: New ideas for Earth-relevant space applications (H2020-EO-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2995678.75
EU funding (EUR): 2995678.0
Participants: 14
Project status: CLOSED

The main objective of this proposal is to develop new methods to retrieve sea ice parameters from existing (and imminent) satellite sensors to provide enhanced products for polar operators and prediction systems, specifically addressing extreme and unexpected conditions. Automatic remote sensing products traditionally provide general information on sea ice conditions such as ice extent and concentration. However, for ice charting, tactical navigation and management of off-shore activities much more important is to know and avoid hazardous sea ice conditions. In general, sea ice hazards are related to sea ice thickness. More often than not polar ships and off-shore platforms are only operating during summer seasons and certain regions. This is because they are designed to resist typical forces of induced by pack ice, but they are not designed to resist the extreme sea ice conditions. Ongoing climate warming has manifested as shrinking and thinning of pack ice in the Arctic. This is a primary driver for the increasing shipping, oil and gas explorations and mining activities in the Arctic. However, severe sea ice conditions still exist and in consequence many locations are impossible for ship based operations. Moreover, year-to-year variability of sea ice is very large and hazardous multiyear ice (MYI) floes sometimes appear also in typically seasonally ice free regions. In order to response needs of increase polar activities, we propose to focus on detection of sea ice extremes and automatic production of “sea ice warnings” products. In particular, we aim for a detection of MYI floes in a area composed mostly first-year ice from synthetic aperture radar (SAR), heavily ridged ice regions from SAR, the thickest ice from radar altimeter (RA) thickness profiles, regional anomalies of thick or thin ice via passive microwave (PMW) data, sea ice areas vulnerable for the wave action, detection of early/late melting season and improving capabilities to forecast seasonal sea ice extremes.

Keywords: sea ice,polar oceans,sentinel,cryosat,sea ice classification,ice thickness,seasonal forecasting
4DSpace: integrated study for space weather at high latitudes (POLAR-4DSpace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2026-05-31
Duration (months): 69.0
Total project cost (EUR): 1999111.0
EU funding (EUR): 1999111.0
Participants: 1
Project status: SIGNED

Ionosphere is the partially ionized, outermost part of the Earth’s atmosphere. Its dynamics is inherently complex and affected by dynamic conditions in the solar wind. In the polar regions, it is directly coupled to the Earth’s magnetosphere and space plasma. The polar ionosphere is subject to the auroral particle precipitation, instabilities and turbulence, which all influence the energy transfer through the ionosphere and lead to plasma density irregularities which lead to scintillations of trans-ionospheric radio signals. Irregularities span over a large range of scales, from thousands of kilometers down to centimeters, making their investigation a highly challenging task. The state of ionosphere at high latitudes is a crucial aspect of the space weather, which has important impact on today’s society, in particular in the context of increasing shipping, aviation, and other operations in the Arctic. Understanding processes in the polar ionosphere, their technological impacts, and laying foundations for robust models for forecasting space weather effects are one of the major goals in space science. This project will determine the role of auroral particle precipitations and geomagnetic activity for the development of plasma irregularities at high latitudes, and their impacts on the global navigation satellite systems. Through an integrated approach, combining in-situ measurements by sounding rockets with novel multi-payloads, cutting-edge numerical simulations, and statistical studies with ground- and satellite-based observations at both hemispheres, it will provide groundbreaking understanding of plasma irregularities in the polar ionosphere, give insight into the energy transfer in the ionosphere, and lay foundations for the space weather models that will improve security of operations in the polar regions. The project is across scientific domains: it deals with the Earth’s Ionosphere, the near-Earth space environment, and fundamental processes in plasma physics.

Keywords: space weather,aurora,plasma irregularities,scintillations,polar ionosphere
Quantum Communications for ALL (QCALL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Spain,Italy,Switzerland,France,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-12-01
End date: 2021-05-31
Duration (months): 54.0
Total project cost (EUR): 3924884.52
EU funding (EUR): 3924884.52
Participants: 11
Project status: CLOSED

Quantum Communications for ALL (QCALL) endeavors to take the next necessary steps to bring the developing quantum technologies closer to the doorsteps of end users. Quantum communications (QC) is well-known for its offering ultra-secure cryptographic key-exchange schemes—resilient to any future technological advancement. QCALL will empower a nucleus of researchers in this area to provide secure communications in our continent and, in the long run, to our connections worldwide. With the large scale violations of privacy in the EU exchange of information, this is a crucial moment to pursue this objective. By covering a range of projects, with short, mid, and long-term visions, and using a balanced and multifaceted training programme, QCALL trains a cadre of highly qualified interdisciplinary workforce capable of shaping the R&D section of the field, hence accelerating its widespread adoption. This will ensure that EU will remain at the frontier of research on secure communications and advanced QC systems and devices. In QCALL, we explore the challenges of integrating quantum and classical communication networks; this will be essential in providing cost-efficient services. We experimentally examine and theoretically study new protocols by which network users can exchange secure keys with each other. We investigate disruptive technologies that enable wireless access to such quantum networks, and develop new devices and protocols that enable multi-party QC. Our meticulously planned training programme includes components from shared taught courses through to scientific schools and complementary-skill workshops, supplemented by secondment opportunities and innovative outreach and dissemination activities. This will create a structured model for doctoral training in EU that will last beyond the life of the project, so will the industry-academic collaborations that are essential to the development of the disruptive technologies that will make QC available to ALL.

Keywords: quantum key distribution,quantum networks,quantum repeaters,memory,satellite,wireless,mobile,quantum communications,quantum technology,terahertz,thz technology
All Solid-State Super-Twinning Photon Microscope (SUPERTWIN)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Switzerland,Switzerland,Switzerland,Belarus,France,Netherlands
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-03-01
End date: 2019-10-31
Duration (months): 44.0
Total project cost (EUR): 3939516.25
EU funding (EUR): 3925921.75
Participants: 9
Project status: CLOSED

The goal of the project is to develop the technology foundation for an advanced optical microscope imaging at a resolution beyond the Rayleigh limit, which is set by the photon wavelength. The proposed microscope technique is based on super-twinning photon states (N-partite entangled states) with the de Broglie wavelength equal to a fraction of the photon wavelength. Such microscopy technique will comprise building blocks for object illumination, capturing of scattered twinning photons and data processing. Based on advanced group-III nitride and III-V alloy epitaxial growths and wafer processing techniques we will build the first solid-state emitter of highly entangled photon states, utilizing the cooperative effect of Dicke superradiance (super-fluorescence) emission. Single-photon avalanche detector arrays with data pre-processing capabilities sufficient for capturing high-order field correlation functions of scattered twinning photons will be developed. A dedicated data processing algorithm for extracting the image of an illuminated object from the statistics of scattered twinning photons will complement the hardware. The project goal is to demonstrate imaging at 42 nm spatial resolution using 5-partite entangled photons at 420 nm wavelength. This quantum imaging technology will open the way for compact, portable, super-resolution microscope techniques, with no moving parts and no requirements to the optical properties of the sample.

Keywords: photon entanglement,n partite entanglement,superfluoresence,dicke superradiance,quantum,imaging,hanbury brown and twiss effect
Institut Curie EuReCa PhD Programme (EuReCa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2020-10-01
End date: 2027-03-31
Duration (months): 78.0
Total project cost (EUR): 6346080.0
EU funding (EUR): 3173040.0
Participants: 1
Project status: SIGNED

Institut Curie proposes an innovative COFUND programme, EuReCa (Europe Research & Care) with the following aims: (1) to train a new generation of early-stage researchers (ESRs) able to achieve excellence in basic sciences and their clinical and industrial applications in cancerology; (2) to implement innovative actions for career support exposing ESRs to our ‘3i’ vision: international, intersectoral and interdisciplinary experience; (3) to consolidate its leadership within its wide network of public and private partners, facilitating exchange of best practices in innovative doctoral training, providing a structured and effective training program to prepare ESRs to successfully enter the increasingly competitive labour market. Institut Curie is a leading Excellence Cancer Centre bringing together an internationally-renowned interdisciplinary Research Centre and Hospital Group. This proposal will benefit in particular from the expansion of Institut Curie’s unique bench-to-bedside approach which brings together new research teams synergizing the expertise of basic scientists and physicians. The strong focus of this proposal on fostering interactions between basic and clinical research as well as the industrial sector will create a new generation of scientists able to quickly transfer results from fundamental research to patient care. This will take the form of diagnostics, prognostics, predictive biomarkers and imaging tests, treatment strategies, new drugs, new radiotherapy techniques, and public health initiatives on prevention and screening. At Institut Curie, the ambitious ESRs fellows of the EuReCa programme will be involved in the three pillars of the fight against cancer: Cutting-Edge Research, Advanced Healthcare, Information & Data Management. EuReCa aims to build a multi-faceted community able to communicate, interact, build and share expertise to tackle the challenges of cancer, ultimately leading to better health outcomes and fewer deaths due to cancer.

Keywords: cancer,health,translational research,epigenetics,genetics,cell biology,physical chemistry,biophysics,immunology,systems biology,biomarkers,epidemiology,personalized medicine
Organoids for Virus Research - An innovative training-ETN programme (OrganoVIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland,Belgium,Poland,France,Netherlands,Netherlands,Netherlands,Netherlands,United States,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 3983591.88
EU funding (EUR): 3983591.88
Participants: 16
Project status: CLOSED

OrganoVIR (Organoids for Virus Research) will train young researchers (ESRs) in the field of organoids and virology. Human viral infection studies lack suitable experimental models as animal models or conventional 2-dimensional (2D) cell cultures do not translate to human infection. OrganoVIR makes use of the breakthrough in the culturing of primary human cells into 3D cultures (organoids). Within this ETN programme, organoids will be used for the first time to study human viral infections in their natural environment. OrganoVIR includes leading partners in virology and organoid technology covering 7 academic institutes, 3 life science companies, 1 organoid technology private company, 2 non-profit organisations, a national public health institute and a business school originating from 8 countries. The aim is to introduce and establish human organoids as superior models for viral pathogenesis studies and antiviral testing, thus replacing animal models and reducing animal use. OrganoVIR provides a full package ETN programme for ESRs to learn the science of innovative 3D culture systems for virus research as well as financial, commercial, ethical, communicative, policy and dissemination aspects for optimal valorization. The projects are intensified by significant secondments at commercial, governmental and non-profit partner institutes. OrganoVIR provides: - High-ranked scientific and technical training in an interdisciplinary, intersectoral and international top research project - Training in transferrable managerial skills, including a pre-MBA - Implementation of innovative organoid technology for viral pathogenesis studies and antiviral development - Innovation in organoid technology by co-culture design and high throughput screening. OrganoVIR combines frontier research with an innovative training programme in a complementary network, certifying high impact scientists.

Keywords: virology,pathogenesis,3d cell culture,organoids,antivirals,viral entry,high throughput,pre,personalized journey
Note-taking and Notebooks as Channels of Medieval Academic Dissemination across Europe (NOTA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Romania
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1175100.0
EU funding (EUR): 1175100.0
Participants: 1
Project status: SIGNED

Note-taking is a common intellectual practice. In academia, it is a universal endeavor that we share with students since the origin of the universities. Yet no one has focused on this practice as an original and independent object of research that, once investigated, will bring innovation and expand our knowledge of European intellectual history. Project NOTA is an ambitious enterprise, rooted in the discovery that decoding medieval notebooks produced in the context of late medieval universities will reveal invisible aspects of the process of producing scientific knowledge, of the European networking of scholars, and of the dynamic circulation of texts. Stemming from the Faculty of Theology during the 14th and 15th centuries, when paper invaded the university as an accessible material support, the student’s notebooks constitute the ideal laboratory in which we can investigate how knowledge was formed and disseminated by means of note-taking. It was one of the superior faculties, meaning that the note-takers had reached intellectual maturity, offering notes of better quality than those of students in the liberal arts. Proposing a unique corpus of Latin manuscripts, project NOTA will launch creative reflections on the motivation and the technical aspects involved in producing notebooks. The project will combine interdisciplinary approaches (doctrinal, codicological and paleographical) and will impact the present state of the art by showing the potential of data that can be obtained by deciphering the practice of note-taking. New concepts will be launched (classification of notebooks, technical practices), traces of unknown authors and texts will be identified, and connections between scholars, institutions and texts will be established, fully justifying the recognition of notebooks as a new subject in the field of intellectual history and as an element of cultural identity shared by universities all around Europe.

Keywords: note taking,latin,critical editions,codicology,intellectual tools,theories of memory,notebooks,commentaries on the sentences,principia,medieval academic exercises