Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Platelet-derived Integrin- and Tetraspanin-enriched Tethers as key effectors in thrombo-Inflammation (PITT-Inflame)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2499250.0
EU funding (EUR): 2499250.0
Participants: 1
Project status: SIGNED

Platelets are mediators of haemostasis and thrombosis, but also increasingly recognized as versatile effector cells of innate immunity. The concept of thrombo-inflammation recognizes that thrombotic and inflammatory pathomechanisms are closely intertwined. Platelets thereby act as central orchestrators of immune cell trafficking, vascular barrier function and organ integrity and contribute to organ injury in severe disorders with limited treatment options (e.g. stroke, sepsis, ARDS). The underlying molecular mechanisms are not known. I recently discovered an unexpected novel effector mechanism in platelets with potentially huge impact for understanding these cells in health and disease: Resting platelets can rapidly reorganize the entire pool of their principal adhesion receptor, integrin αIIbβ3, along with its associated tetraspanins and signalling machinery into ´disintegration´ complexes (DISCs) in distinct membrane microdomains. These DISCS serve as building blocks for a novel organelle, the ´Platelet-derived Integrin and Tetraspanin-enriched Tether´ (PITT). PITTs are loaded with signalling molecules, ribosomes and RNA and can segregate from the platelet to promote thrombo-inflammation. Also β1-integrins as well as glycoprotein (GP)VI can be integrated into DISCs and deposited at discrete adhesion points. I therefore postulate that circulating platelets have the capacity to use their principal adhesion/signalling machineries in two fundamentally different ways and thereby switch between the haemostatic and a thrombo-inflammatory effector programme. If proven correct, this would implicate a radically new paradigm in platelet biology, and open new avenues for the treatment of a wide range of diseases with major societal impact. PITT-Inflame will (i) provide a detailed molecular composition and architecture of DISCs and PITTs; (ii) decipher underlying signalling networks; (iii) identify PITT-induced effects on target cells and (iv) deduce therapeutic strategies.

Keywords: platelet,integrin,receptor regulation,thrombo inflammation
Real Processing in Phase Change Memory (Real-PCM-PIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Separation of processing and memory is the root cause of the main performance and energy bottlenecks in modern computers. In the PI's ERC Stg, we proposed to combine data processing and storage in the same cells, to develop a novel unit called the 'memristive memory processing unit' (mMPU). This unit was based on resistive RAM (RRAM), which is still not commercial in large capacity. A different memory technology, phase change memory (PCM), is commercially available in large capacity (for example, Intel's Optane has 1.5 TB memory), and can serve as an appropriate technology to form an mMPU with short time-to-market. In this PoC, we aim to experimentally demonstrate a working mMPU based on commercially-available PCM. This mMPU will enable fast and energy efficient computers that are cheaper than existing computers. This will impact different applications such as artificial intelligence, databases, and genomics. The mMPU-based computers will allow faster and cheaper execution of the aforementioned applications. In this proposal, we target the required technical and business steps required to develop such an mMPU and to commercialize it.
Data hub for the Creation of Energy communities at Local Level and to Advance Research on them (DATA CELLAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Greece,Spain,Belgium,Norway,France,Portugal,Bulgaria,Germany,Ireland,Netherlands,Cyprus,Austria,Switzerland,United Kingdom
Call: Establish the grounds for a common European energy data space (HORIZON-CL5-2021-D3-01, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 8530793.93
EU funding (EUR): 6954062.5
Participants: 33
Project status: SIGNED

Local Energy communities (LEC) have been recognized by EC as key measure to boost EU energy transition. At the same time digitalization of EU energy system and a proper data sharing among energy players look crucial to foster best practice sharing and the creation of a knowledge community to tackle one of the most urgent global crisis of our society: climate change. DATA CELLAR aims therefore to create a public energy dataspace that will support the creation, development and management of LECs in EU. Such dataspace will be easy to be populated (also via an innovative rewarded private metering approach) and easy to interact with, also guaranteeing a smooth integration with other EU energy dataspaces and providing to LEC stakeholders services and tools for developing their activities. DATA CELLAR will implement a collaborative platform providing an interoperable, modular, and secure energy data space capable of delivering access to datasets, Decision Support Tool and Artificial Intelligence (AI) models to serve and support the spread LECs. In the framework of the project DATA CELLAR and its services will be used by representatives of nine validation cases around EU and with different level of maturity promoted by different type of actors such as public authorities, DSOs, aggregators etc.. DATA CELLAR will also used to drive transversal activities such as EU energy scenarios and market planning (EDF, NODES). DATA CELLAR will facilitate data collection/sharing from both LEC stakeholders, researchers and tenants also targeting the development of a marketplace and a tokenization rewarding approach that can stimulate such actors to both use and populate the data space. At this purpose and also considering data interaction with the other EU existing energy dataspaces/initiatives (GAIA-X, OPEN DEI…) towards the creation of a federated EU Energy Data Space, DATA CELLAR will also study ethical, regulatory, cybersecurity and governance aspects for data handling/sharing.

Keywords: energy communities,ai,federation of data spaces,private metering,marketplace,tokenization
Harnessing the microbial potential of fermented foods for healthy and sustainable food systems (DOMINO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: France,Belgium,Ireland,Italy,Spain,Germany,Netherlands,Austria,Estonia,United Kingdom
Call: Microbes for healthy and sustainable food and diets (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 10878273.25
EU funding (EUR): 10815148.25
Participants: 22
Project status: SIGNED

European consumers are expressing a clear demand for healthier and more sustainable food. Fermented foods (FFs) have the potential to meet these expectations but there is a need to demonstrate their health impacts scientifically, while developing innovative strategies to tackle both sustainability and nutritional health. In this frame, DOMINO will investigate the health impacts of FF-based diet on a healthy population and a cohort suffering from metabolic syndrome to better focus on health biomarkers. We will provide tailor-made microbial solutions using an integrated ‘omics’ strategy and computational biology modelling to address the challenges associated with sustainable food production and healthy nutrition. In six food case studies, selected as representative of the wide diversity of plant-based FF prototypes, we will involve key stakeholders in a multi-actor approach. These objectives will lead to key results: the characterization of the health effect of milk kefir; the application of diagnosis tools based on healthy microbiome/human biomarkers to inform dietary recommendations based on FF for people with metabolic syndrome; the development of an open access database and new computational tools for profiling food microbiomes metabolic interaction during food fermentation and their overlap with the healthy gut microbiome; the delivery of a research and innovation workflow to facilitate the smart design of functional healthy FF, bio-waste valorisation, sustainable processes on plant-based food case studies using the leverage of food microbiomes’ biodiversity; all supported by a federation of key stakeholders and citizens through several living labs and a tailored dissemination strategy. Together we will develop and move towards a vision of the future of FFs in Europe while enhancing the trust of citizens in the food value chain through their involvement and genuine integration of their perspectives, paving the way for citizen-friendly innovation.

Keywords: fermented food microbiome consumer behaviour living labs computational biology
Advanced Energy Performance Assessment towards Smart Living in Building and District Level (SmartLivingEPC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Greece,Spain,Estonia,Austria,Belgium,Germany,Cyprus,Romania,Ireland,Netherlands,Italy
Call: Advanced energy performance assessment and certification (HORIZON-CL5-2021-D4-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 4745064.99
EU funding (EUR): 4100533.0
Participants: 18
Project status: SIGNED

SmartLivingEPC project aims to deliver a certificate which will be issued with the use of digitized tools and retrieve the necessary assessment information for the building shell and building systems from BIM literacy, including enriched energy and sustainability related information for the as designed and the actual performance of the building. SmartLivingEPC will provide information in relation to the operational behaviour of the building, by introducing a new rating scale, based on a weighted approach of life cycle performance aspects, building smartness assessment and information on the actual performance of the technical systems of buildings provided by technical audits. The new methodologies to be developed, will be based on existing European standards, whereas at the same time, they will trigger the development of new technical standards for smart energy performance certificates. The new certification scheme will also expand its scope, covering aspects related to water consumption, as well as noise pollution and acoustics. SmartLivingEPC certificate will be fully compatible with digital logbooks, as well as with building renovation passports in order to allow the integration of the building energy performance information in digital databases. A special aspect of SmartLivingEPC will be its application in building complexes, with the aim of energy certification at the neighbourhood scale. SmartLivingEPC aspires to develop two parallel schemes, one at the building level (Building EPC) and one at the level of building complex level (Complex EPC), with the ultimate goal in the near future of certification of building complexes, based on the certification of individual units, as well as on additional aspects following an integrated participatory and neighborhood based approach. 16 partners from 12 European countries will collaborate and provide their expertise and resources within the 36 months of SmartLivingEPC lifetime.

Keywords: operational rating,smart readiness indicator,lca and lcc analysis,ieq,bim,digital twin,smart monitoring systems,technical audits,building complex assessment,digital logbooks,ai services
THE SCIENCE FOR STRONGER SOCIETIES (SCIENCE&FUTURE) (SCIENCE&FUTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Türkiye
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-15
End date: 2026-04-14
Duration (months): 24.0
Total project cost (EUR): 220125.0
EU funding (EUR): 220125.0
Participants: 7
Project status: SIGNED

Scince&Future is a collaborative initiative that seeks to blend scientific research on climate change and natural disasters conducted by leading universities (Sakarya University, Kocaeli University, and Düzce University) with the involvement of local authorities (Sakarya Governorship and various participating organizations) from three neighboring provinces, all while engaging the broader public. Within the framework of this two-year project, the plan involves the orchestration of educational events such as competitions, workshops, presentations, and science nights, each hosted by our project partners. The goal is to foster a connection between scientists and the general public, encouraging young individuals to actively engage in scientific endeavors and pursue careers in these critical fields as a direct outcome of the year-long activities. Throughout all these activities, the project also aims to disseminate the European Union's science policies, with a particular focus on climate change and environmental policies, to the diverse layers of the local community.

Keywords: mscaandcitizens,climate change,natural disasters,resilience cities,open science
Molecular circuits of sex dimorphism in cardiometabolic traits and risk factors (Sex Dimorphism)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-07-31
Duration (months): 31.0
Total project cost (EUR): 211665.68
EU funding (EUR): 211665.68
Participants: 1
Project status: CLOSED

Cardiometabolic traits and risk factors including cardiovascular diseases, type 2 diabetes, and hypertension are the leading causes of death worldwide. These conditions exhibit some degree of sex differences, including differences in incidence or prevalence, age of onset, severity, disease progression, susceptibility, response to treatment and pharmacological adverse events. Unfortunately, the reasons behind this sex dimorphism are largely unknown, hampering the realization of an effective personalized medicine. My project will focus on understanding the genetic and molecular components that differentially impact men and women. I will first carry out sex stratified genome-wide association studies for cardiovascular diseases, type 2 diabetes, hypertension and obesity using large population biobanks to evaluate the effects of known-genetic variants within each sex and to identify novel loci that may have been previously undetected. I will then use molecular quantitative trait loci (QTLs) to identify specific gene expression changes and proteins modulated by these variants and that are likely to be involved in sex-specific development of cardiometabolic traits and modulation of risk factors. I will then validate putative causal genes using Mendelian randomization approaches. This will lead to optimize therapeutics and find new drug target to perform equally well in males and females and will open the door to improve personalized and precision medicine in the near future.

Keywords: sex differences,mendelian randomization
Sense Of Number in Invertebrate Cognition (SONIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Australia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 274974.72
EU funding (EUR): 274974.72
Participants: 2
Project status: SIGNED

We are experimenting a novel cognitive revolution with the accumulation of evidence on the unexpected intelligence of key invertebrate species. Indeed, abstraction faculties, emotion-like behaviours, social imitation, or tool use, among other capacities, were long considered as the prerogative of large-brained vertebrates but now proven to be accessible to Invertebrates although to a limited extent. With this project, we wish to pursue this dynamic by offering an invertebrate perspective on the evolution of numerical cognition. In addition, our evolutionary distance with Invertebrate offers the best opportunity to compare numerical systems that evolved independently. Numerical cognition is indeed an ideal framework to explore the limit of what an invertebrate brain can perform with a comparative perspective thanks to historically well-defined and testable levels of complexity in processing quantities. Building from the established evidence of the impressive honeybees’ numerical skills and cephalopods’ general cognition, we propose to explore the limit of the cognitive levels accessible to Invertebrates by testing the possibility for bees and octopus to possess an abstract representation of numbers: are they capable of a symbolic and cross-modal representation of quantities? The proposed research program will thus offer timely decisive elements for a better understanding on the physiological and ecological constraints for numerical cognitive faculties to emerge.

Keywords: invertebrate cognition sense of number bees and cephalopods numeric abilities symbolic representation
Advanced Characterisation Methodologies to assess and predict the Health and Environmental Risks of Advanced Materials (MACRAME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,France,Luxembourg,Slovenia,Spain,Italy,Switzerland,United Kingdom,Netherlands
Call: Advanced characterisation methodologies to assess and predict the health and environmental risks of nanomaterials (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 4201652.5
EU funding (EUR): 4201652.5
Participants: 20
Project status: SIGNED

MACRAMÉ’s Central Objective is to: • detect, characterise and quantify Advanced Materials during their processing and product-life-cycle (incl. recycling/end-of-life) to assess (e.g. ecotox-/tox-test) the resulting impact on (human) health and the environment if/when they pose (intended or unintended) exposures to humans and/or the environment and to • advance (i.e. prepare for standardisation & harmonisation/’regulatory validation’) the wide-spread applicability and application of the developed test- and characterisation methods, by demonstrating their effectiveness and efficiency in the context of existing, market-relevant industrial materials, processes and products. In alignment with the EU strategies to secure the safety and sustainability of enabling and emerging technologies (incl. those based on chemicals and materials, as addressed in the EU’s Chemical Strategy for Sustainability (2020), and in the European Green Deal (2021)), the MACRAMÉ Project focusses on the development of methodologies that are applicable to ‘Advanced Materials (AdMas)’ - a categories that includes, but surpasses that of ‘nanomaterials’ (EU, ‘Definition of a Nanomaterial’), and that is aligned with the future-oriented innovation, safety and sustainability considerations at the OECD (OECD (2020)), the EU (EU (2022)), and several of its Member States (e.g. Germany (2021)); this will be achieved by focussing the development and demonstration of novel methods and methodologies, as well as the advancement of their harmonisation and standardisation on (planned inhalable carbon-based AdMas in a variety of morphologies and dimensions, moving beyond spherical particles: (a) graphene-related material (GRM), (b) carbon fibres (CNTs), and (c) Poly Lactic-co-Glycolic Acid (PLGA). The focus on carbon-based AdMa is due to unsolved detection and characterisation issues especially in complex media.

Keywords: advanced nano materials,control materials and methods,regulatory relevance,advanced characterisation methods and in vitro models for hazard assessment,cost effective methods,standardisation
Bringing heat into the bright side in bio-hybrid LEDs – Heat-BLED (Heat-BLED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

The main objective of Heat-BLED is the development of new biophosphors able to either stand high photon flux excitations without generating heat or to smartly use the heat in dual functional devices. Heat-BLED will provide experimental insight into the interaction of polymer-fluorescence protein matrix with light and most importantly, provide a solid experimental basis to determine optimum composition of the matrix to effectively reduce heat generation. This will be accomplished by establishing a protocol to quantify the dielectric loss heating under device operating conditions. Moreover, the second approach will be applied to design an innovative family of color down-converting coatings for Bio-hybrid light emitting diodes (Bio-HLED) that repurposes the heat generated under operando conditions. To this end, two strategies will be used. Firstly, the fluorescent protein will be covalently linked to a nanothermometer. Second, a multi-layered biophosphor coating will be fabricated using a transparent thermoelectric generator to convert heat into an electricity.

Keywords: biophosphor,dielectric loss spectroscopy,bio hybrid light emitting diodes,thermoelectric,thermal management