Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards a Mechanistic Account of Maintenance Goals (TMAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

People need to invest tremendous effort and motivational resources to ensure that all the valuable things they have will be maintained, on both an individual level (e.g., family, households, health) and a societal level (e.g., public infrastructures, the natural environment). Nevertheless, little is known about people’s motivation to routinely maintain, nurture, and care for what they have. Psychological theory on motivation has focused on approach (e.g., starting a new relationship) and avoidance goals (e.g., avoiding separation), and left maintenance goals understudied . Addressing this gap in the literature, the current project introduces and tests a first general model of goal-directed maintenance. Instead of increasing gains or avoiding negative outcomes, maintenance goals are used to stabilize positive current states. When maintaining one’s existing relationship, for instance, people are not only avoiding separation; they are engaged in a set of acts that stabilizes their relationship in a manner that keeps acute threats like separation at bay. In a similar manner, environmentalism is not only the aspiration to slow down global warming (an avoidance goal), but also, and perhaps more importantly, the aspiration that humanity will learn to maintain a stable relationship with the biological world. The proposed empirical research will combine lab studies using implicit behavioral measures with experience sampling methods (ESM). The results of this research will lay the foundation for the study of maintenance goals as distinct from approach and avoidance goals, shedding light on processes involved in the most pressing socio-political issues of our time.

Keywords: goal regulation motivation maintenance cybernetics
Spatial Crosstalk in Immuno-Oncology (spaXio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,France,United States,Switzerland,Germany,Spain
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 4573029.19
EU funding (EUR): 4393218.24
Participants: 18
Project status: SIGNED

Metastasis, the leading cause of cancer-related deaths, arises from the spread of cancer cells to distant organs, where they compromise normal organ function. Cellular interactions, paracrine factors, and the metabolic environment promote the formation of metastatic niches that facilitate tumour cell survival and proliferation. While single-cell data have improved our understanding of tumours and their heterogeneity, our knowledge of metastatic niches is still very incomplete. In particular, the lack of spatial context makes it difficult to address critical knowledge gaps in metastatic niche biology which limits our progress in the development of targeted therapeutic interventions. The doctoral network spaXio aims to tackle this challenge by training doctoral candidates (DCs) in cutting-edge techniques, including spatially resolved multi-omics, advanced tumoroid modelling, and computational approaches, including bioinformatics and AI-based prediction models. DCs will conduct systemic analyses of metastatic niches across diverse organ systems and tumour types to improve our understanding of metastatic niche formation and uncover novel therapeutic targets. SpaXio provides comprehensive, multidisciplinary training that combines hands-on laboratory experience, computational data integration, and (industry) secondments. Regular cross-disciplinary workshops and seminars boost innovation and collaboration, while transferable skills training encompasses communication, ethical research, open science, entrepreneurship, and sustainability. By partnering with a network of leading European and international academic, clinical, and industrial experts, spaXio ensures that DCs are exposed to diverse research environments and approaches. This fosters their ability to think across borders, advance technologies and integrate multiple large datasets into a complete systemic picture, preparing them to be leaders in cancer research and shape the rapidly evolving field of spatial biology.

Keywords: spatial biology,metastasis,immune micro environments,digital twins
The Potential Link between Transmembrane Sensors and Nucleic Acid Remodeling in the Shango Anti-Phage Defense System (SHARP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

The SHARP (Shango Anti-phage Remodeling Pathway) project aims to explore the molecular mechanism of Shango system, a widespread bacterial anti-phage defense module. While the well-known CRISPR-Cas systems have revolutionized genome editing, bacterial defense strategies encompass over 130 distinct gene modules and present a treasure chest for novel biotechnologies. To eliminate viral threats, these systems employ various mechanisms, either pre- or post-injection. Shango consists of three core genes: SngA, SngB, and SngC with bioinformatically predicted functions thus far. SngA, annotated as tellurite stress response element, has two transmembrane helices and is proposed to detect an unknown viral signal. Its C-terminal domain may recruit SngB and SngC. SngB, a member of the AAA+ ATPase family, together with SngC, a DEAD-box helicase, likely participates in DNA remodeling. In this project, I hypothesize that Shango induces changes in nucleic acid topology, thus impairing phage genome integrity and preventing its replication, though the exact mechanism remains elusive. By isolating phage escapers capable of bypassing Shango, I aim to identify the triggering signal. Subsequently, I will analyze the specificity and unwinding activity of SngB and SngC using biochemical assays. Advanced techniques such as single-particle cryogenic electron microscopy (cryo-EM) will be used to elucidate distinct functional states of Shango. Leveraging Dr. N. Taylor’s expertise, I aim to assemble the complete complex of Shango together with its transmembrane helices. To reveal the spatial-temporal regulation of the system during phage attack, I will employ Total Internal Reflection Fluorescence (TIRF) microscopy to visualize the co-localization of Shango proteins and phages. This project not only explores new aspects of bacterial stress responses, but also aims to pioneer tools for signal-induced nucleic acid manipulations, opening up the possibilities in biotechnological applications.

Keywords: anti phage defense,shango,tellurite resistance,membrane proteins,dead h box helicase
Natural microbial interactions in winemaking-associated ecosystems as a tool to foster wine innovation (Eco2Wine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Germany,Georgia,Slovenia,Spain,South Africa,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 2440396.8
EU funding (EUR): 2440396.8
Participants: 23
Project status: SIGNED

The Eco2Wine project aims at providing a new generation of PhD graduated employees for the wine sector who will be able to manage winemaking-associated ecosystems, protect and control the biodiversity, and use this knowhow to reduce unsustainable interventions in natural environments while improving wine sustainability and “natural wine” production. Winemaking-associated ecosystems are complex environments in which more or less stable and evolutionary relevant interactions among species, and between each species and abiotic components, are established. In recent years the direct manipulation of these ecosystems has gained considerable interest in wine science because of the need of boosting sustainable, socially relevant and ecofriendly choices for the wine production while meeting the growing consumer demand for more diverse wine styles. To better map and exploit the natural biodiversity of winemaking-associated ecosystems, the understanding of the relevant microbiota, the various ecological interactions within those biota and of the molecular mechanisms involved in interactions is essential. Such studies will allow to describe how these ecosystems work and how their intelligent exploitation can benefit the wine world. The training program is divided in 4 areas of interest: wine ecology, wine innovation, wine business and wine science communication. The consortium includes 9 beneficiaries and 12 partner organizations that possess complementary competencies and are working with success in wine research. The level of quality of these institutions, the long-term collaborations established in the past joint European project, YeSVitE (GA612441), and the appropriate exchange scheme of training with private companies will sustain an efficient transfer of knowledge between PhD students, the broader scientific community and the relevant social and economic actors. The project will have a relevant impact on the wine research field, winemakers and all potential stakeholders.

Keywords: winemaking associated ecosystems,microbial interactions,grapevine and grape bioprotection,wine biocontrol,wine innovation,wine business,wine and science communication,food sciences
XR mEdia eCOsystem (XReco)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Greece,Portugal,Netherlands,Italy,Israel,Belgium,Romania,Switzerland
Call: Innovation for Media, including eXtended Reality (IA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-09-01
End date: 2025-10-31
Duration (months): 38.0
Total project cost (EUR): 10356484.48
EU funding (EUR): 8331200.0
Participants: 23
Project status: SIGNED

While media organisations increasingly support non-linear experiences for the consumer, those are still limited to single channels and media domains. Although several media organisations have recently succeeded in breaking data silos, data sharing is mostly limited to the organisation. Thus, there are challenges for producing content feeding multiple channels with different granularities and structures, mainly related to data discovery, management and (re-)use. XRECO will create a new data-driven ecosystem for the media industry, focusing on facilitating data sharing, search and discovery and supporting creation of news and entertainment content, in particular, the creation and (re-)use of location-related 2D and 3D assets and the creation of XR experiences. The ecosystem core, represented by a Neural Media Repository (NMR), will foster inter-organisation content sharing and provide increased access to content for media creators, considering novel data monetization and rights management policies. A set of AI-based media transformation services are built around the NMR to produce novel media- and XR experiences, including 3D neural reconstructions, neural based device localisation, image stitching, de-/re-lighting and holoportation. The developed technology will be validated in use case scenarios for (i) the news media for XR-based broadcasting and automatic and customized multitarget news publishing, and for (ii) location-based information and entertainment content, with applications in tourism and the automotive industry.

Keywords: data sharing,xr production,content monetization,news production
Supply-chain mechanisms for safeguarding South American Chaco’s last intact forests (FOREST-CHAINS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Belgium,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

Agricultural expansion continues to drive the loss of tropical forests, resulting in huge social-ecological trade-offs, including biodiversity loss, carbon emissions, and the erosion of the resource base of forest-dependent communities. Halting deforestation has thus become a global policy goal but is currently hindered by four main knowledge gaps, all of which this action will address. First, not all tropical forests are equal, and many are degraded, but where remaining high-nature-value (HNV) forests are is often unknown. Second, many forest conservation tools are available, but their effectiveness in protecting HNV forests is unclear. Third, supply-chain interventions are potentially powerful, but missing supply-chain data limits their application. Finally, the relative importance of domestic vs. foreign consumption is often unknown. Focussing on the South American Chaco, an understudied global deforestation hotspot, this action will use state-of-the-art remote sensing, impact evaluation, and supply-chain analyses to provide the first assessments of the distribution of HNV forests in the Chaco, which policy options effectively protect them, and what the environmental footprints of domestically used vs. traded forest-risk commodities produced are. Through the action, the ER will broaden his research scope, acquire new technical and transferable skills, and train leadership ability. Together, this will make him a very competitive candidate for independent positions in sustainability science. The outcomes of the action include high-impact publications as well as policy-relevant information delivered to key stakeholders in South America and Europe through various dissemination pathways. Overall, this action will impact our understanding of the status and governance of HNV forests in the neglected dry tropics, which is critical for the EU’s due diligence initiatives seeking clean supply chains, and for maintaining social-ecological integrity in the Global South.

Keywords: supply chains,environmental governance,forest conservation,remote sensing,tropical dry forests,indigenous peoples
Year-Round, Fire-Safe, and Sustainable Solar Management Materials (SOLAR-MATER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

At present, temperature regulation of spaces and buildings is responsible for 31% of the global final energy consumption and 30% of the entire worldwide CO2 emissions. Although solar thermal conversion (high solar absorption) and passive radiation cooling (high solar reflection) have presented huge potential for the energy-free temperature regulation, the opposite mechanisms limit their application in one object, failing to respond to the changing climates year-round. Besides, applied onto the surface of plenty of spaces and buildings, high fire safety and sustainable processability are vitally important yet urgent to be addressed. Therefore, facing these challenges, the overarching aim of this ambitious yet achievable project (SOLAR-MATER) is to develop year-round, fire-safe, and sustainable solar management materials, via the spontaneous and energy-free switch of solar thermal conversion and passive radiation cooling based on a break-through approach, which is a creative integration of thermochromic microcapsules (TCMs), synthesis of biomass flame-retardant chain extenders, and solvent-free polymer coating technology. In details, based on microencapsulation technology and structure design, TCMs designed will optimise the solar reflectivity, solar absorptivity, and IR emissivity, by introducing B-O and Si-O bonds with high IR emissivity to high-refractive TiO2-based shell materials; fully biomass flame-retardant chain extenders and inorganic shell materials will enhance the fire safety, with the condensed flame retardancy mechanism; meanwhile, solvent-free polymer coating will impart desirable processability and further enhance the sustainability. SOLAR-MATER is a typical multidisciplinary and requires complementary expertise from the host (Polymer Chemistry, Fire Retardant Materials) and the researcher (Solar Energy, Radiation Cooling), contributing to achieving the “Sustainable Development Goals” and “European Green Deal” of EU policies.

Keywords: flame retardant fire safety photo thermal conversion passive radiation cooling
Giving Voice to Hispanic Chant through a Phylogenetic Study of Medieval Plainchant (RESOUND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2499500.0
EU funding (EUR): 2499500.0
Participants: 3
Project status: SIGNED

Plainchant, the sacred Christian chant, is the most ancient Western corpus preserved in musical notation. Before the unifying adoption of the Gregorian liturgy throughout Europe in the 9th century, a number of liturgical families –each one with its own chant repertoire– emerged in the ancient Western Roman provinces. Among them, the Hispanic liturgy was recorded –text and music– in manuscripts between ca. 700 and ca. 1300. These sources allow us to know the liturgy’s ceremonies and texts, but not the melodies themselves. In fact, notational signs do not indicate the specific intervals between the notes, since they were written prior to the use of a notational system in which each individual sign contains precise pitch information. As a consequence, the Hispanic musical notation is considered indecipherable and its thousands of melodies still remain silent. RESOUND aims to achieve what has so far been considered an impossible task: bringing to life the sounds of Hispanic chant. To accomplish this goal, we will use tools from the fields of bioinformatics, genetics, computational analysis, aural architecture and virtual restoration of sound and images, along with tools from the humanities, including musical performance. Computational analysis aside, these tools have never been used in the study of medieval chant, let alone in combination. By recovering the sounds of Hispanic chant and establishing these innovative methods, we will be able to offer new understandings of the generative and evolutionary dynamics of the European plainchant repertoires. In this way, we will not only recuperate the Hispanic melodies, but also restore a significant part of the soundscape of medieval Europe. Thus, by reversing the standard approach via focusing on a territory considered peripheral, we will shed new light on the process of cultural creation in the European Middle Ages.

Keywords: digital humanities,big data,computational analysis,plainchant,medieval music,creation processes
Innovating Civic Engagement: Pedagogies for a Resilient Generation (I-CIVIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Estonia,Finland,France,Germany,Ireland,Italy,United Kingdom
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 1718430.0
EU funding (EUR): 1718430.0
Participants: 10
Project status: SIGNED

The primary goal of the Civic Engagement: Pedagogies for a Resilient Generation program is to establish a comprehensive and multidisciplinary network of international experts, fostering cross-sector collaboration to address the complexities and ramifications of democratic engagement, civic participation, and digital literacy. The project adresses the critical and multifaceted issue of democratic deficits among youth, particularly the rise of anti-democratic movements across Europe.Seeks to bridge these gaps by leveraging interdisciplinary research, international collaboration, and innovative methodologies to foster democratic resilience among European youth. At its core, the project aims to develop scalable, community-based pedagogical frameworks that integrate insights from pedagogy, sociology, psychology, political science, and digital literacy. Recognizing the disconnection between schools and their communities, I-CIVIC focuses on creating synergies between educational institutions and local entities such as museums, libraries, cultural associations, sports clubs, and local governance bodies. The objetives are: Understand and Address the Gaps in Democratic Education,Create Innovative Tools and Educational Frameworks,Build Inclusive and Scalable Educational Practices and Provide Excellent Training and Supervision.I-CIVIC adopts a holistic approach to addressing the complex challenges presented by democratic deficits, declining civic engagement, misinformation, and inclusivity gaps in education. This approach is grounded in a multidisciplinary, cross-sector exchange network that aims to break down barriers between disciplines and sectors. I-CIVIC is designed to tackle several interconnected scientific challenges related to democratic participation, digital literacy, and community-based education. These challenges are addressed through innovative research, interdisciplinary collaboration, and the development of practical tools and frameworks.

Keywords: youth,democratic engagement,civic participation,inclusive democratic growth,innovation,education,community weel being