Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Therapeutic Atmospheres (THERASPHERES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 2
Project status: SIGNED

Mental health challenges represent one of the most pressing issues of 21st-century science, with an estimated 9% of the population currently experiencing a mental disorder and 25% expected to face one at some point in their lives. As these challenges become increasingly prevalent, the importance of understanding what contributes to effective healing cannot be overstated. While existing research recognizes that the environment in which therapy occurs—such as the layout, lighting, sound, and furniture of a room—can significantly influence therapeutic outcomes, there remains a notable gap in the literature regarding how these therapeutic spaces affect individuals and shape the course of psychotherapy. The "Therapeutic Atmospheres" (THERASPHERES) project seeks to address this gap by exploring how the experience of affective atmospheres within therapeutic settings impacts the effectiveness of therapy, particularly in forming therapeutic alliances and fostering significant therapeutic change events. The primary objectives of this project are threefold: (1) to map the various interpretations of 'atmosphere' within the literature on phenomenological psychiatry and situated affectivity, (2) to assess how the experience of atmospheres in consultation rooms influences therapeutic change processes, and (3) to refine existing conceptualizations of 'atmosphere' within the field of phenomenological psychiatry and situated affectivity and explore their application to other research domains. By employing a novel method that integrates phenomenological interviews with the analysis of video recordings, THERASPHERES will systematically assess the role of affective atmospheres in therapeutic processes. Ultimately, this project aims to enhance our understanding of how to create spaces that foster better mental health outcomes.

Keywords: psychotherapy,phenomenology,embodiment,4e cognition,qualitative methods
Microbial interactions driven by organic and inorganic metabolic exchange and their role in present and future biogeochemical cycles (BioGeoMicrobes)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Many biogeochemical processes, such as carbon cycling in marine ecosystems, are driven by interactions between micro-algae and bacteria. Global warming changes our oceans, impacts algal-bacterial interactions, and affects the processes these interactions propel. If we are to find ways to ameliorate the effects of global warming, we need to understand the molecular mechanisms that mediate these key algal-bacterial interactions, and integrate this knowledge into a biogeochemical context. A major challenge in studying these interactions – often mediated by secreted metabolites – is their complexity in nature. Therefore, we established ecologically relevant model systems with tunable complexities including algal-bacterial co-cultures, genetically tractable synthetic communities, and mini-cosms to study such interactions in context. These allow us to monitor and manipulate algae, bacteria, and their environment. We will combine microbiology and Earth sciences approaches to generate a “blueprint” of metabolic circuits that shape the algal-bacterial-environmental interaction landscape. Specifically, we will study: 1) The organic and inorganic secreted metabolome of algae and bacteria. 2) The physiological response of algae and bacteria to specific organic and inorganic metabolites, and the metabolic circuitry connecting algae, bacteria, and the marine environment. 3) The influence of climate change on algal-bacterial-environmental interactions, gaining insight into how key players in the ocean will likely respond to future climate. Unveiling mechanisms of microbial interactions under various environmental conditions allows us to understand how future climate will impact these interactions and the processes they drive. Our interdisciplinary research offers a novel framework for studying the role of microbial interactions in biogeochemical cycling, it will contribute to improved climate change models, and will provide valuable data for ocean stewardship policy makers.

Keywords: microbial interactions,microbial biogeochemistry,algal bacterial interactions,coccolithophores,emiliania huxleyi,roseobacters,climate change,proxy
When was Greenland ‘green’? – Perspectives from basal ice and sediments from ice cores. (Green2Ice)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Denmark,Belgium,France,Canada
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-04-01
End date: 2029-03-31
Duration (months): 72.0
Total project cost (EUR): 13929477.0
EU funding (EUR): 13929477.0
Participants: 6
Project status: SIGNED

Green2Ice will investigate the deepest and oldest ice and basal sediments drilled from the Greenland Ice Sheet (GrIS). Ice cores have been drilled the last 55 years, but the deepest ice containing basal materials has been preserved until now, and still holds undeciphered paleoclimatic messages. The breakthrough of Green2Ice is to develop and apply cutting edge dating methods on this unique sample collection and hence to reconstruct the age and the stability of the GrIS. A hypothesis to test is if the present GrIS formed at the time of the Mid Pleistocene Transition, 1,2 - 0.8 million years ago. One innovation of Green2Ice is to gain paleo-information of the past size of the GrIS to constrain future tipping points. This knowledge will reduce the uncertainty on estimates of future sea level rise. Green2Ice will bring together four PIs from three world leading institutions with complementary skills to lift this strongly interdisciplinary program. We will drill a replicate core at GRIP, to supplement the available material from five existing ice cores and ensure retrieval of sediments and rock material from beneath the GrIS summit. We will develop, improve and apply novel dating techniques (cosmogenic and radiogenic nuclides, OSL/IRSL, modeling of gas and isotope diffusion) to place constraints on past waxing and waning of the GrIS. State-of-the-art methodologies on fossil remains, organic matter, in situ produced and consumed greenhouse gases, and ancient bio-molecules will provide insights on the types of ecosystems and environmental conditions that emerged during ice-free conditions. Interpretation will include ice sheet modelling with data benchmarking to establish the climatic sensitivity of the GrIS. Earth system modelling and collaboration with the groups preparing the IPCC AR7 will bring the knowledge of the past into the future. The rare and unique basal ice and material can only be used once. This is the main high risk high gain component of Green2Ice.

Keywords: greenland ice sheet,mid pleistocene transition,ice free greenland,ecosystem,mass loss,sea level rise
Mapping genetic suppression interaction networks in DNA break repair disorders (SupDSB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

DNA double-strand breaks (DSBs) occur frequently during a cell’s lifetime and constitute the most cytotoxic DNA lesion. DSBs compromise genetic integrity and have the potential to trigger cell death and generate pathological mutations. To counteract such threat, cells possess a complex protein network termed DSB response (DSBR) which senses, signals and repairs DSBs. Two predominant mechanisms repair DSBs: homologous recombination (HR) and non-homologous end joining (NHEJ). While loss of DSBR factors such as KU and XRCC4 (i.e. NHEJ proteins) or BRCA1 and BRCA2 (i.e. HR proteins) leads to early embryonic lethality and cell death, inactivating somatic mutations in these very same genes are associated with certain immunological and neurological disorders, premature ageing and cancer. This implies the existence of a suppressive (epi)genetic background that enables diseased cells to tolerate the otherwise lethal loss of essential DSBR factors. This project aims to systematically identify suppressor mutations which rescue viability upon loss of essential HR (BRCA1 and BRCA2) and NHEJ (KU80 and XRCC4) effectors. To reach such goal, I propose to (a.) genetically sensitize wild-type “healthy” mouse embryonic stem cells and B lymphoid cells by introducing mutations using a genome-wide CRISPR KO library. In such diversely sensitized background, I will then (b.) trigger the acute degradation of KU80, XRCC4, BRCA1 and BRCA2 proteins, using the auxin-inducible degron (AID) system. Suppressor mutations will be directly identified by sequencing sgRNA retrieved from survivor cells. (c.) The resulting suppression network maps will be integrated to clinical datasets to identify the relevance of these mutations in disease. Together, this project will unravel the DSBR protein networks that permit cell survival under different DNA repair-deficient conditions, encountered notably in cancer; paving way for personalized disease prevention and treatment strategies.

Keywords: dna double strand break dsb repair,homologous recombination,nonhomologous end joining,genetic interactions,synthetic viability,auxin indicuble degron,crispr,mouse es cells,b cells
Alternative PROteins from MIcrobial fermentation of non-conventional SEA sources for Next-Generation food, feed and non-food bio-based applications (PROMISEANG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Portugal,Poland,Hungary,Germany
Call: Proteins from alternative and unconventional sources (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 4535097.5
EU funding (EUR): 4535097.5
Participants: 11
Project status: SIGNED

PROMISEANG is a 48-month project that aims to develop novel alternative proteins from marine underexploited sources (marine invertebrate and macroalgae discards and industrial biowastes) through biomass fermentation (solid-state and submerge processes), generating new microbial protein biomass, meeting market requirements for food, feed, and non-food (biomedicine, pharma and cosmetic) bio-based applications. A technically and economically viable biorefinery for microbial-based protein production will be demonstrated during the project, enabling higher production yields, reduced production periods, minimized environmental impacts, diminish the imports, and reduced production costs for proteins. PROMISEANG contributes to CBE JU with a translational, multidisciplinary and multi-actor approach, including cooperation between industries and academia across EU, to achieve a greener bio-based Europe. Following a zero-waste approach, PROMISEANG will also recover and biosynthesize interesting non-protein bio compounds and molecules (i.e., polysaccharides, lipids, polyphenols, PHA, etc.) for further use in food, feed and non-food applications. Research on novel protein streams from sustainable alternative sources will contribute to increase the protein availability in the EU, and reduce the actual dependency on imports. In short, PROMISEANG will upcycle of marine food wastes (WP2), apply innovative and sustainable technologies (incl. biotechnology, biochemistry, microbial fermentations, digital tools and machine learning, WP3), validate the nutritious, safety and bioactivities of protein products (WP4), valorise fermentation side streams through nanotechnology (WP5) and design, development and validation of food, feed and non-food products in relevant environments (WP6) including improvement of environmental, economic and social aspects, and production-efficiency performances (WP7), and strong communication, dissemination and exploitation plans (WP8).

Keywords: alternative proteins,biomass fermentation,biorefinery,sustainable bio based products,zero waste approach,upciclying of biowastes,multi actor approach,environmental performance assessment
INTERCONNECTED EUROPEAN INNOVATION ECOSYSTEMS FOR SUSTAINABLE GROWTH AND DEVELOPMENT (InnovationGUIDE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Türkiye,Netherlands,Spain,Malta
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2023-CONNECT-01, 2023)
Start date: 2024-01-01
End date: 2024-12-31
Duration (months): 12.0
Total project cost (EUR): 517889.29
EU funding (EUR): 496862.5
Participants: 6
Project status: CLOSED

Rural innovation ecosystems refer to the networks of individuals, organizations, and institutions in rural areas that work together to foster innovation, entrepreneurship, and economic development. In a rural innovation ecosystem, these actors collaborate to identify and develop new ideas, products, and services that address local challenges and opportunities. Successful rural innovation ecosystems typically have several key characteristics, including strong community engagement, supportive policies and regulations, access to capital and resources, and a culture of experimentation and learning. InnovationGUIDE objectives closely align with the European Commission Communication on a New European Innovation Agenda objectives by increasing the inclusion and interconnection of less represented regions and actors into a more strongly integrated European ecosystem. With this starting point InnovationGUIDE designed to pinpoint regional needs and possibilities for connecting them into international ecosystem which can be a driver of regional economic development, attract and retain talent, build local businesses, and create new jobs and industries. InnovationGUIDE will use 12 months to map the geography covered by the partners and design roadmaps and bi-annual plans for future to serve rural communities overcoming the disparities with proper services and activities compared to urban ecosystems. InnovationGUIDE will have a focus for policymakers, researchers, and practitioners interested in promoting sustainable, inclusive economic growth in rural areas. Connecting Dutch, Spanish, Maltese and Turkish experience and ecosystems InnovationGUIDE will enable information and knowledge diffusion from stronger innovator ecosystems to moderate innovator ecosystems.

Keywords: rural innovation,ecosystem connection,framework development
Refractive Index Observer (RIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Microscale chemical gradients are essential in life sciences, materials science, and chemical processes, yet existing measurement methods rely on fluorophores or dyes that inherently alter system properties and provide only indirect insights. With this PoC, we aim to revolutionize their quantification by further developing and ultimately commercializing RIO - the Refractive Index Observer - an add-on device for optical microscopes that enables label-free, high-resolution characterization of chemical gradients at the microscale. The technology uses Fabry-Pérot interferometry to obtain time-resolved two-dimensional (2D) refractive index (RI) maps at the microscale and convert this information into chemical gradient mapping. With a resolution of at least 2x10-5 RI units, RIO is comparable to a benchtop refractometer for bulk samples but with the spatial resolution of a typical optical microscope and a 10-millisecond time resolution. RIO is born out of the ERC CoG “ACTIVE_ADAPTIVE” as a tool to measure chemical gradients in active matter systems. We have already patented the technology, which is at TRL4. With this PoC we aim at taking RIO to TRL6/7 and lay the groundwork for its commercialization by: 1. Developing the current hardware to (i) push the time resolution to sub-millisecond while maintaining the highest RI resolution and (ii) create a palette of customized interferometric microfluidic chips to cover a broad range of application fields. 2. Advancing the control system and software via a robust, professional and intuitive graphical user interface (GUI). 3. Conducting a techno-economic assessment of the technology alongside a product-market fit evaluation. 4. Carrying out user testing and fundraising for pre-commercialization. If successfully implemented, RIO has the potential to disrupt the way microscopy is performed on liquid samples across a wide range of disciplines, including electrochemistry, microrobotics, cell biology, and materials science.
Rural Empowerment HUBS for climate resilience (REHUBS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Spain,Italy,Austria,Cyprus,Slovenia,Lithuania,Portugal,Germany,Belgium,Croatia,Switzerland
Call: Demonstration of solutions specifically suited to rural areas and small/ medium size population local communities (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 7132906.25
EU funding (EUR): 6370833.13
Participants: 27
Project status: SIGNED

REHUBS addresses the issues of climate vulnerability in rural areas and small to medium-sized communities, which are particularly susceptible to climate risks such as droughts, heatwaves, wildfires, floods, and biodiversity loss. REHUBS’ goal is to enhance climate resiliency of these areas by developing an integrated framework of adaptation solutions, advanced digital tools, and participatory approaches, tailored to the specific needs of the rural communities. The project will design, implement and validate a Climate Risk Assessment model, an Advanced Early Warning System, Flood and Drought Modelling tools, Smart Irrigation Systems, a Circular Water Recovery Treatment, a Rapid Wildfire Detection System, as well as a Risk Assessment and Adaptation Platform that will recommend a list of cost-effective nature based solutions (NBS). REHUBS will promote knowledge transfer, enhance the adaptation capacity of local authorities, and upskill local actors through an online academy, an AI support chatbot and through fostering stakeholder collaboration through the project’s established Rural Micro Hubs (RMHs). The solutions developed in REHUBS will be implemented and validated across four Demonstration Cases, with replication in three additional Replication Cases, ensuring that they, not only address immediate climate risks, but also build long-term resilience by integrating climate adaptation strategies into local governance frameworks. Additionally, the project will introduce innovative financial instruments to support the sustainable implementation of these solutions, ensuring both their cost-effectiveness and replicability across different European regions. The project's outcomes will contribute significantly to enhancing the adaptive capacity of rural communities, supporting EU climate goals, and ensuring socio-economic and environmental sustainability in regions facing critical climate challenges.

Keywords: climate risk assessment,rural areas,local authorities,climate resilience,rural micro hubs,water management,wildfire detection,early warning systems