Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Transparent Hole Conductor by Combinatorial Techniques for Next-Generation Energy Conversion Devices (HOCOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-03-31
Duration (months): 31.0
Total project cost (EUR): 212238.72
EU funding (EUR): 212238.72
Participants: 2
Project status: CLOSED

Materials that are both electrically conductive and optically transparent are an essential element in important light conversion applications, such as solar cells, solar fuels, displays, and illumination. Their high conductivity is achieved either through electrons (n-type) or through positively charge holes (p-type). However, the figure of merit of state-of-the-art p-type materials is more than 100 times lower than that of the best n-type materials. Therefore current devices must be designed to have electrons as the main charge carriers at the transparent electrode. If this constraint was removed, new design possibilities could be explored, and even new types of devices (e.g. see-through electronic transistors) could be fabricated. Thus, the goal of this project is to synthesize a p-type transparent conductor with a figure of merit twice as high as that of the current state-of-the-art hole conductive material. I will focus on phosphide materials, as recent theoretical work points to their favorable hole-conducting properties. Among phosphides, I have prioritized one specific material and selected two other promising materials as back-ups. I will learn and apply a high-throughput combinatorial approach championed by my host institution (NREL, USA) in order to accelerate the development of optimal synthesis conditions and dopants. This knowledge will be transferred to my European host (HZB, Germany), which is currently building a full combinatorial research lab. I will use HZB’s combinatorial tools to fabricate simple diode structures on top of the material developed at NREL, using an n-type sulfide semiconductor. Electrical analysis of the diodes will indicate the practical applicability of the new hole conductor in a real device. In parallel, I will be trained in advanced defect spectroscopy techniques at HZB. They will reveal the nature of defects that compensate the dominant p-type character of the hole conductor, thus defining a roadmap for further improvement.

Keywords: transparent conductive materials,thin films,solar cells,optoelectronics,combinatorial materials,research,sputter deposition,pulsed laser deposition
Metasurfaces for ultrafast light structuring (METAFAST)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Bulgaria,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 2498831.25
EU funding (EUR): 2498831.25
Participants: 5
Project status: SIGNED

The METAFAST project aims to develop a novel class of synthetic nonlinear optical materials, or metamaterials, as a disruptive platform enabling unprecedented ultrafast dynamical control over polarization and wavefront of light. In particular, we will develop ultracompact all-optical modulators capable of faster than ever structuring of the spin and orbital angular momentum (SOAM) of light beams. Such ultrafast optical modulation offers an exceptionally robust method for the encoding of digital information in free space optical links, being also resistant to eavesdropping thanks to topological protection. The state-of-the-art of SOAM modulation technology to date is largely based on liquid crystals or digital micromirrors, which suffer from intrinsic limits in terms of speed (of the order of thousands bit per second) and prevent real-world telecom applications (demanding billions bit per second data rate). Thanks to our novel approach to ultrafast light structuring via nonlinear optical metasurfaces we will tackle the formidable challenge of increasing by 6 orders of magnitude the speed of SOAM modulators. Such a result could provide the metropolitan optical network with the kind of speed, robustness and security requested to support the 5G radio technology, thus underpinning the forthcoming fourth industrial revolution with fast communications for the so-called internet of things.
Malus genome editing via CRISPR/Cas9 to develop sustainable pest free apples (MalusEdit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-16
End date: 2022-03-17
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Apple is one of the most important crop. Pathogens causing powdery mildew, fire blight, and scab represent serious threats to apple cultivation. These pathogens are mainly controlled by pesticides with a negative impact on the environment and possibly on the health of the consumers on the long term. Resistant cultivars are the most effective and sustainable means to control these threats. Resistance to pathogens is usually conferred to apples by the introgression of R-genes from wild cultivars but such approach is not durable. Suppression of genes used by pathogens for infection (S-genes) can reduce pathogen attack. CRISPR/Cas9-mediated genome editing was used to mutate S-genes but these attempts were limited to single genes and were based on the stable integration of the editing machinery preventing these plants from being accepted by customers. The main objective of this project is to use CRISPR/Cas9 to create a multi-resistant apple variety by the simultaneous mutation of S-genes which are responsible for susceptibility to powdery mildew and fire blight. The main challenge will be to introduce such mutations using a “transgene-free” approach which is not based on protoplast transformation. The innovative approach consists on delivering the editing machinery via Agrobacterium tumefaciens or particle bombardment to apple cells and then eliminate editing components after mutation using an inducible site-specific recombination-based system. The final goal is to obtain a multi-resistant, sustainable and transgene-free apple. The second objective of the project is to develop a method for regeneration of apple plants from protoplast which safeguard genetic stability during regeneration to allow genome editing in apple protoplasts using pre-assembled Cas9-sgRNA ribonucleoproteins.

Keywords: malus x domestica,fire blight,powdery mildew,cisgenesis,crispr,cas9,agrobacterium mediated,transformation,particle bombardment,sustainable agricolture,plant disease resistance,s genes
No country for old sperm: male aging, sperm aging, and external stressors as determinants of sperm quality and fertility (SPERMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Deterioration in sperm quality with age is a major cause of male infertility. This has particular socio-economic relevance for Europe where fatherhood is increasingly delayed and infertility has reached near epidemic levels, costing the EU €4 billion per annum. The mechanisms causing, and the full consequences of declining sperm quality with age remain very poorly understood. For example, it is unclear how much of the reduction in sperm quality is due to advanced male age or the time sperm are stored within males reproductive organs, and we do not understand the mechanisms responsible for deteriorating sperm quality with increasing male age. The general aim of this project is to disentangle the effects of male aging and sperm aging on sperm quality, fertility and reproductive fitness using Drosophila melanogaster as a model. We will also test putative mechanisms thought to cause age-related fertility declines and test two possible general pathways through which sperm age. This proposal is a much needed integration of evolutionary ecology and sperm physiology, benefiting from the ideal match of skills and expertise of the Applicant (Tourmente - physiology), and the PI (Hosken - evolution). Since the mechanisms and phenomena studied are conserved across animals, the research proposed has high potential to produce results relevant to fundamental and applied research in human aging and reproductive health and animal breeding. The MSC fellowship will be pivotal for Applicants development toward independent research and offers the unique opportunity to work in one of the most prominent evolutionary ecology groups worldwide. The Biosciences Department at the University of Exeter is world-leading and provides excellent opportunities for the personal career development of the Applicant, who in turn brings novel skills to Exeter that will greatly benefit this group.

Keywords: sperm quality,aging,fertility,sperm function,iis pathway,reproductive fitness,cellular metabolism,gene expression
Three-dimensional nanoscale magnetic structures (3DNANOMAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Austria,Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2603096.0
EU funding (EUR): 1828558.19
Participants: 2
Project status: SIGNED

Three-dimensional (3D) nanomagnets, with unconventional spin and topological properties, are very promising systems for the future development of greener, more capable, multi-functional technologies. However, the significant experimental challenges associated with the fabrication and probing of 3D nanoscale geometries and spin configurations, have restricted most studies to date in this field, to either computational and theoretical works, or experiments in simple 3D geometries that do not fully exploit the potential of moving to three dimensions. Making use of recently-developed 3D nano-printing and magneto-optical tools, the 3DNANOMAG project will carry out first experimental investigations in ultra-advanced nanomagnetic systems with a variety of complex 3D geometries, multi-layered materials and chiral spin configurations. These techniques will be combined with state-of-the-art magnetic microscopy and simulations, in collaboration with worldwide experts. The project will study 3D nanowire conduits, where the magnetic state and propagation properties of domain walls and skyrmionic textures will be tailored via symmetry-breaking nano-curvature effects, leading to ground-breaking investigations in 3D spintronic devices. In addition, new types of topologically non-trivial spin textures and localised magnetic defects will be realised via the pioneering exploitation of 3D geometrical effects in multi-strand nanowires with strong interwire coupling. To carry out the project, 2.6M€ are requested, which will be employed to form a research team working for 60 months, use of microscopy facilities and the purchase of nanofabrication equipment specially designed for the investigation of 3D nanostructures.

Keywords: nanotechnology,nanomagnetism,spintronics,magneto optics,3d nanofabrication,electron microscopy,x ray,microscopy
Development and market launch of novel technology for production of nutritionally complete plant proteins called FIDOs - “Functional (Protein) Isolates Derived from Oilseeds”. (FIDOs)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Poland
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Meeting demand for sustainable plant-based protein is set to be a crucial challenge for future food security. For that reason NapiFeryn BioTech (www.napiferyn.pl) aims to develop and commercialize technologies for the isolation of nutritional components from plant sources and in particular from legumes, cereals and oilseeds. To do so, co-founders rely on their extensive international experience, gained at world-class food companies as well as actively cooperating with academics and scientists. Our main objective today is to bring to the global market a novel, cost-efficient and eco-friendly technology that enables production of nutritionally complete plant proteins derived from rapeseed under the commercial name FIDOs “Functional (Protein) Isolates Derived from Oilseeds”. The project addresses the problem of protein deficiency in human diet, which is a consequence among others of a lack of commercially available technology for isolating proteins from rapeseed in the global food industry. The key market application of FIDOs technology is to utilize the “side stream” from rapeseed crushing process, currently used as animal feed, and turn it into valuable food proteins of high purity and functionality, later to fully valorise the material and produce additional “streams” for the food industry: syrups, biofuel and dietary fibres and lastly to develop our own food formulas based on FIDOs. Finally, to fully exploit and to commercialize this new and EU-based technology, a comprehensive business model was proposed. Future growth will be driven through alliances with Oil Processors and licensing of FIDOs technology. The aim is to supply the food markets with FIDOs, firstly European countries with the further aim of reaching the USA, India and China. FIDOs has great potential to attract the attention of the big players of the Novel Food Markets and Food Formulators specializing in production of food for athletes, vegetarians, vegans, senior citizens and clinical patients.

Keywords: novel food,plant protein,rapeseed protein,functional proteins,oilseeds,sustainable alternative to animal proteins,valorization of side stream from oil processing industry,biorefinery
High Performance Low Cost Virtual Studios for Creative Industries SMEs (SMARTSET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Spain,Spain,Hungary,Finland,Norway
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 1352756.25
EU funding (EUR): 1078659.0
Participants: 7
Project status: CLOSED

The vision in project SmartSet is to develop a low cost virtual studio solution that will have the same quality and functionality of high cost solutions used by large broadcast companies so that the SmartSet solution will: A. Increase the competitiveness of the European creative industries, particularly in the broadcast media sector; B. Contribute to expanding a vibrant EU technological ecosystem for the creative industries' needs and foster exchanges between the creative industries SMEs and providers of ICT innovative solutions; C. Stimulate the adoption and deployment of innovative ICT solutions by creative industries SMEs, particularly in the broadcast media and content production sector. Creative industry SMEs such as regional and local TV stations, production companies are at a disadvantage when it comes to access to cost-effective virtual studio technology. To realise the vision in project SmartSet the objectives for this Innovation Action are: 1. Formulate and implement a stakeholder consultation process to support creative industry SMEs in leveraging emerging ICT technologies for the development of innovative products, tools, applications and services with high commercial potential. 2. Devise mechanisms to verify that user requirements are being met and the innovation potential can be clearly demonstrated. 3. Define and integrate a novel state of the art graphics engine with advanced image and video processing capabilities into a simplified and inexpensive self-contained SmartSet hardware platform. 4. Build a validation environment to ensure user requirements are central to system performance and are incorporated into the design. 5. Refine the SmartSet solution according validation results and prepare bug-free solution for commercialisation. 6. Create and implement a dissemination strategy and plan designed to generate a critical mass of interest in the SmartSet solution. 7. Design and implement an exploitation strategy and business modelling process

Keywords: virtual studio,low cost,creative industry,small tv stations,cost effective,3d graphics,real time graphics,broadcast,live streaming,iptv
Streamlined Geriatric and Oncological evaluation based on IC Technology for holistic patient-oriented healthcare management for older multimorbid patients (GERONTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Switzerland,Norway,Belgium,France,France,France,Netherlands
Call: Healthcare interventions for the management of the elderly multimorbid patient (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 5998759.0
EU funding (EUR): 5998759.0
Participants: 12
Project status: SIGNED

Population is aging and the number of complex multimorbid patients to manage will increase sharply. Disease-centred approach is not appropriate to manage these patients. Change to a patient-centred approach will simplify care pathways, secure management and treatment decision making and decrease healthcare costs. It will be a real breakthrough for daily practice with multiple impacts that must be quantified. GERONTE multimorbid patient-centred system proposes: 1) Coordination of management by a patient-tailored, interdisciplinary health professional consortium (HPC), including hospital- and home-based professionals, with a case manager; 2) Timely registration of symptoms and patient-reported outcomes at home through a web-based app for anticipation of avoidable adverse events; 3) Proposal of self-management guidelines according to intrinsic capacity evaluation by geriatrician for patient-driven improvement of independent living; 4) Structured collection of data from electronic health record into a dashboard made available to HPC members as well as patient and caregiver, thanks to its capacity to securely interoperate with all electronic health records including software managing medical data. The whole approach will be co-designed with patients, informal care givers and health professionals. Cancer is an excellent model to develop this approach in multimorbid patients because it is frequent and commonly associated with other morbidities in older patients but also because of its major impact on patients’ general status and coexistent diseases. Cancer already benefits from a multidisciplinary management model that GERONTE will enhance, strengthening exchange of holistic data, role of primary care and case management. GERONTE will also provide new country-specific guidelines and best practices for implementation across Europe and for improved management of older multimorbid patients including improved quality of life and independent living at decreased costs.

Keywords: multimorbidity,ict tools,interdisciplinarity,case management,cancer,healthcare costs,independent living,quality of life,self management,co design,caregivers,shared decision making
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE (PREVENT-2024)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Increasing occurrence of obesity and diabetes is the major threat to cardiovascular health of our century. Whereas the field is saturated with “omics” strategies aimed at improving prediction of cardiometabolic disease (CMD), mechanism-orientated prevention strategies, which is what the population calls for, are lacking. We here propose three completely new and high-risk strategies to prevent CMD in large subsets of the population, who have elevated risk due to measurable endocrine abnormalities. SUBPROJECT 1: We test if the increased CMD risk linked to high levels of the intestinal fat absorption and storage promoting hormone neurotensin (NTS), can be improved by: (A) blockade of NTS using monoclonal antibodies in mice and (B) inhibition of NTS secretion and intestinal fat uptake with the drug orlistat in humans. SUBPROJECT 2: High plasma levels of vasopressin (VP) (present in 25% of the population) is a strong risk factor for later CMD and the dominating cause of high VP is low water intake. We therefore test if the elevated CMD risk in subjects with high VP can be reduced by increasing water intake in a large 12-month randomized trial of 1.5 L water supplementation vs control therapy. SUBPROJECT 3: Aderenomedullin (ADM), whose endothelial secretion is enhanced in obesity, has beneficial effects on the intravascular wall but in the extravascular space, to which it diffuses freely, it may promote diabetes. We investigate how long-term increase and decrease of levels of bioactive ADM in the intra- and extravascular compartments, respectively, affect atherosclerosis and glucose metabolism in mice. In humans we test if a monoclonal antibody, which traps ADM in the circulation (while still allowing it to bind to its endothelial receptors) and drains it from the extravascular space, improves vascular function and glucose metabolism. We provide completely novel, mechanism-orientated and near-future applicable strategies for primary prevention of CMD.

Keywords: prevention,cardiometabolic disease,diabetes,obesity,cardiovascular disease,vasopressin,neurotensin,adrenomedullin