Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clinical Proof of concept for a RNA-targeting Oligonucleotide for a Cystic fibrosis-F508del MEDication (PRO-CF-MED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Belgium,Belgium,France,Netherlands,Netherlands,Denmark
Call: New therapies for chronic non-communicable diseases (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2017-12-31
Duration (months): 32.0
Total project cost (EUR): 21237179.5
EU funding (EUR): 5997139.0
Participants: 7
Project status: CLOSED

Cystic fibrosis (CF) is a progressive life-shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leading to a dysfunctional CFTR protein. The disease affects over 70,000 patients worldwide and while many mutations are known, the F508del mutation affects 90% of all patients. The absence of CFTR in the plasma membrane leads to a dramatic decrease in chloride efflux, resulting in viscous mucus that causes severe symptoms in vital organs like the lungs and intestines. For CF patients that suffer from the life threatening F508del mutation only palliative treatment exist. PRO-CF-MED addresses the specific challenge of this call by introducing the first disease modifying medication for the treatment of the CF patients with F508del mutation. The PRO-CF-MED project has been designed to assess the potential clinical efficacy of QR-010, an innovative disease modifying oligonucleotide-based treatment for F508del patients. Partners within PRO-CF-MED have generated very promising preclinical evidence for QR-010 which allows for further clinical assessment of QR-010 in clinical trials. PRO-CF-MED will enable the fast translation of QR-010 towards clinical practice and market authorisation. PRO-CF-MED has the potential to transform this life-threatening condition into a manageable one.

Keywords: cystic fibrosis,oligonucleotide,disease modifying medication,first in humans clinical trial,f508del mutation
Photo-Digital Channelizer for Flexible Digital High Throughput Satellites (PhLEXSAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,Czechia,United Kingdom,United Kingdom
Call: Satellite communication technologies (H2020-SPACE-2020, 2020)
Start date: 2020-11-01
End date: 2023-09-30
Duration (months): 35.0
Total project cost (EUR): 2960024.25
EU funding (EUR): 2960024.25
Participants: 6
Project status: SIGNED

Photonic technologies are key enablers to satisfy the requirements of future Terabit/s communication satellites. The ability of Photonics to handle high data rates and frequencies is critical in this scenario, where current purely RF technologies are limited in SWaP and performance. However, the use of photonics devices is currently restricted to a few demonstrations in non-critical equipment and with limited degree of integration. PhLEXSAT will increase the maturity level of several key photonic devices and modules to TRL5, designing, fabricating and testing 1) Photonic sampler, 2) ultra-low jitter photonic clock for precise sampling, 3) Photonic-assisted ADC and DAC for digital channelizers for Q/V-band operation and 4) on-board digital processing firmware. Miniaturization will be achieved by fabricating and integrating a modulator photonic integrated circuit (PIC) and high-linear photodiode PIC with electronics in the photonic ADC and DAC components. PhLEXSAT will integrate and demonstrate such building blocks in a test bed proving the suitability of the proposed architecture for Tbps-like, software defined HTS payloads with hundreds of channels with flexible bandwidth allocation up to 1GHz/channel, demonstrating a flexible photo-digital channelizer for high capacity reconfigurable payloads, enabling flexible frequency plans and channelization and dynamic coverage for Ku/Ka/Q/V operation. PhLEXSAT consortium comprises the multidisciplinary skills needed to achieve its objectives and fully exploit its results, with partners representing the whole value chain, from space-grade hardware developers to communications satellite integrators and operators. PhLEXSAT builds on the results of the previous FP7 project PHASER and is complementary to developments made by its partners in previous and existing ESA and EC Projects. PhLEXSAT success will contribute to enhance EU competitiveness and non-n-dependence by developing critical technologies for the EU satellite industry.

Keywords: rf photonics,flexible and reconfigurable photonic payloads,space grade photonic components,photonic adc,photonic dac,on board digital processing,v frequency,photonic integrated circuit
Improving the performance of district heating systems in Central and East Europe (KeepWarm)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Germany,Ukraine,Germany,Croatia,Slovenia,Serbia,Slovenia,Latvia,Czechia
Call: Improving the performance of inefficient district heating networks (H2020-EE-2017-CSA-PPI, 2017)
Start date: 2018-04-01
End date: 2020-12-31
Duration (months): 33.0
Total project cost (EUR): 2098497.5
EU funding (EUR): 2098488.5
Participants: 11
Project status: CLOSED

The Project “Improving the performance of district heating systems in East Europe” – or KeepWarm for short – targets the largest energy user in the EU: Energy demand for heating and cooling (49%). Relying on district heating systems for heat generation is the most effective solution in densely populated areas. However, many district heating systems (DHS) are highly energy inefficient and need to be modernized. Considering that the predominant energy sources used are still fossil fuels (oil, gas or coal) makes interventions ever more urgent. Both statements hold especially for East European countries where old, inefficient district heating systems, mostly fueled by fossil sources, urgently need to be modernized. The unique feature of KeepWarm is its combination of concrete work at pilot systems and its close alignment with national and European multipliers to disseminate this experience broadly. The latter incudes close interaction with potential investors and fund managers to increase the likelihood that KeepWarm business plans receive the necessary funding. The project promotes EU goals of improved and environmental friendly heating and cooling but adapts its exploitation strategy to distinct national windows of opportunities. KeepWarm will work intensively with DHS in seven countries (i) to increase the energy efficiency of these systems; and (ii) to reduce greenhouse gas emissions by promoting a switch from fossil to renewable fuels. This is most urgently needed in the case of large-scale DH systems that are mostly found in Eastern Europe, the focus of this project. Likewise, it is important to ensure that existing DHS that run on renewables do not switch back to fossil fuels.

Keywords: district heating,renewables,retrofitting,refurbishment,modernization,capacity development,funding
Movement Assisting Devices: Manufacturing of personalized Kineto-Dynamics parts and products for workers, elderly and children (MovAiD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Italy,Switzerland,Switzerland,Netherlands,Netherlands,Denmark,United Kingdom,Denmark,United Kingdom
Call: Manufacturing of custom made parts for personalised products (H2020-FoF-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 5954375.0
EU funding (EUR): 5136875.0
Participants: 13
Project status: CLOSED

I - Over forty million workers in the EU are affected by work-place related musculoskeletal disorders, as a result of working in painful or tiring positions and handling heavy loads with repetitive hand or arm movements. II - The aging population is growing fast and approaching the mean age where loss of function and hence loss of mobility is to begin. In addition to diabetic and obesity, in 5 years’ time, there will be significant increase in number of elderly people who require mobility aids or orthoses which need to be fitted in order to enable population to live at their home independently. III - A number of neuromuscular disorders, along with other pathologies such as arthrogryposis, affect children motor patterns in the limbs causing motion deficits. To achieve long term benefits for the European society, the proposal addresses those three groups with the development of a next generation of Movement Assistive Devices (MADs): innovative, “passive” and highly customized kineto-dynamic equipment, built to provide natural compensation of human movements (both upper and lower limbs). MADs will be conceived and developed exploiting a generative design approach (capable to combine unique morphological characteristics with personalized kinematics) coupled with an innovative additive multi-material technology ( capable to deliver specific mechanical properties), By delivering products for mobility enhancement of the older persons, the project directly contributes in dealing with familiar ageing society issues by decreasing the need of care sector and enhancing a reduction of falls with an overall consequent saved costs. In workplace safety, the MAD fosters correct kinesis, injury prevention and improved productivity. Meanwhile, placing focus on the last, third group, MovAiD promotes the final stage of a modern sustainable society by augmenting the quality of life of its youngest members with difficulties in mobility.

Keywords: custom made parts,personalised products,additive manufacturing,generative design,multi materials
Turning the concept of magnetocaloric cooling on its head (cool innov)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-12-31
Duration (months): 63.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Twenty years of research in magnetocaloric materials has failed to provide the necessary breakthrough that will lead to a commercial realisation of this technology and satisfy the urgent global need for more efficient refrigeration. We strongly believe that this is a result of looking in the wrong direction. The cool innov project will achieve this breakthrough by rethinking the whole concept of caloric cooling. We are rejecting the conventional idea of squeezing the best out of magneto-structural phase-change materials in relatively low magnetic fields, and instead we introduce a second stimulus in the form of pressure so that we can exploit, rather than avoid, the hysteresis that is inherent in these materials. The hysteresis will allow us to lock-in the magnetisation at saturation as the magnetising field is removed, so that magnetic fields persisting over a large area will no longer be required (instead, we can use a very focused field), and then demagnetise the material in a second step with an applied stress, enabling us to extract a lot more heat. In this case we only need to apply the magnetic field to a small volume of material, making it a completely new application for commercially available, high-temperature, YBCO-type, bulk superconducting permanent magnets. With the high-field, multi-stimuli approach proven, we will develop new magneto/mechanocaloric materials that match the new high-field, hysteresis-positive approach and start to fabricate novel heat-exchanger structures using additive manufacturing, so that we can combine a mechanically sound heat exchanger having a complex geometry with locally tailored, magneto/mechanocaloric properties. The success of cool innov will be game changing. We are being very ambitious in targeting a revolution in cooling technology, but if we succeed, we will have a huge impact on global energy consumption through greater efficiency, thanks to the novel energy materials that will be discovered within cool innov.

Keywords: magnetic refrigeration,magnetism,additive manufacturing,high throughput by first principles,computational engineering
EUropean LOw Speed Aircraft Model at high Reynolds II (EULOSAM II)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy,Italy
Call: Finalize and improve the manufacturing of the model of a laminar wing configuration bizjet (LSBJ) (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2021-01-31
Duration (months): 28.0
Total project cost (EUR): 1383000.0
EU funding (EUR): 968100.0
Participants: 3
Project status: CLOSED

In laminar flow investigations, several parameters related to manufacturing quality of the aircraft wind tunnel model have to be taken into account since they can strongly affect the laminar-turbulent transition location. Model shape, steps and gaps, waviness and surface roughness of the model, are key parameters for the quality of laminar flow investigation. Even if this effect is not so amply described in literature where few empirical and inaccurate correlations between the roughness height and the transition position can be found, experimental results have shown that distributed roughness strongly affects the laminar-turbulent transition. This phenomenon can be managed through a very good mechanical design able to avoid possible step and gap coming from the integration of different parts composing the model and taking care, in the manufacturing phase, of the waviness and of the surface refinement, both being challenging tasks. Last, but not least, the number of pressure sensors and their integration in the leading region (necessary to correctly capture the stagnation region) requires special and innovative solutions to avoid laminar flow contamination. Fully in line with JTI-CS2-2017-CfP07-AIR-01-30, the overall objective of the project is to support the development and assessment of natural laminar aircraft integrating innovative aerodynamic control surfaces, and High lift technologies. The EULOSAM II project focuses on the modification and completion of a WT-model that allows analysing of the aerodynamic performance of innovative control surfaces and high-lift devices. Model main size is roughly 2.25 m in span for an area of around 1.2 m^2 with a the Horizontal Tail Plane (HTP) of 0.8 m in span for an area of 0.26 m^2. The WT model has the high aspect ratio of around 11 and a low sweep angle of 20°.

Keywords: aircraft model,high reynolds,low speed,laminar flow,laminar turbulent transition
Ultra-high field imaging of perceptual learning and human brain plasticity (Laminar-PL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Learning and experience shape key cognitive functions of the adult human brain and support our ability to interact in complex and dynamic environments. Yet, the brain mechanisms that support our ability to learn from cluttered and inherently ambiguous sensory information and improve our perceptual decisions with training remain largely unknown. My proposal aims to investigate: (i) the neural basis of perceptual learning in the human visual cortex (ii) the neural computations that underlie perceptual learning and (iii) the brain connectivity (i.e. how different brain areas work together) that supports behavioural improvement due to training. To achieve this, I will combine behavioural paradigms measuring perceptual learning, ultra high-field 7T imaging of brain activations at the finer scale of laminar layers (i.e. across cortical depth) and state-of-the-art computational modelling. This integrated multidisciplinary approach will contribute significantly to our knowledge of how the brain optimises its capacity for adaptive behaviour through learning and experience. Further the proposed work has potential practical implications for the design of education and rehabilitation training programmes in life-long development and disease. Finally, this interdisciplinary research experience boosted by collaborations with industrial partners will benefit greatly my career development to an independent researcher in the field of computational cognitive neuroscience.

Keywords: perceptual learning,laminar brain imaging,forward encoding model
Globalizing Anti-Feminism: A Phenomenology of Transnational Networks of Islamic Women Organizations (GlAntiFem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Egypt,Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-10-21
Duration (months): 36.0
Total project cost (EUR): 236091.84
EU funding (EUR): 236091.84
Participants: 2
Project status: SIGNED

This project seeks to study global Islamic women organizations and the emerging transnational movement they represent. These organizations are characterized by an opposition against what they perceive as feminism and westernization and have a global pro-activeness that seek to produce emancipatory projects for women, beyond Islamicate societies. - How can we understand the phenomenon of transnational networks of Islamic women groups and organizations and their anti-feminist discourse? By studying their historical genealogy and contemporary discourse and praxis, this project will explore a) the intimate relationship that their anti-feminist paradigm has with their feminist counterparts, marked by proximity, ambiguity and opposition, b) the emancipatory project that this paradigm espouses on gender issues, c) the institutionalization processes of anti-feminist organizations and their transnational networks and d) the specific activities that these organizations engage in, in attempting to impact UN and EU initiatives both within the UN system and locally in their own societies, using the cases of UN's Sustainable Goals. Based on a wide range of material consisting of fieldwork, literature produced by women affiliated with anti-feminist organizations, interviews with these women and relevant experts in the UN, as well as online material, this project takes a holistic and interdisciplinary and phenomenological approach that take into account anti-feminists' lived experiences shaped by their social, political, economic and religious realities. As countries worldwide seek to fulfil the UN Sustainability Goals by 2030, examining their counter-discourse and how it relates to their local contexts will be vital to understand both how anti-feminists can potentially affect the efforts towards reaching these goals and how these goals are received by an important segment of the society in their countries.

Keywords: anti feminism,islamism,lobbyism,anti colonialism,identity politics,middle east,counter discourse,unsg2030,eu spotlight initiative
Synchrotron Light Industry Applications (Sylinda)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Poland
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 899058.75
EU funding (EUR): 899058.75
Participants: 4
Project status: SIGNED

This project contributes to strengthen the capacities of research institutions of the widening countries, in particular Sylinda aims at boosting the research and development capabilities of SOLARIS, the Polish Synchrotron facility, based on the experience brought by the partners’ consortium. The X-ray Absorption Spectroscopy (XAS) beamline of SOLARIS is to be upgraded with a high resolution spectrometer which will make it scientifically excellent and very attractive for academic and industrial users dealing with low atomic number elements studies. New industry cooperation avenues with the Pharmaceutical-, rubber-, agro-, (micro-) biological, chemical- and cosmetics-sectors will be consequently opened. The SOLARIS staff structure is to be reinforced with an Industrial Liaision Officer, a beamline scientist and a grant officer to better serve those industries as well as the academic community. That staff will be enrolled in a twinning and training programs at the premises of the experienced partners to master their specialties. Special emphasis on improving industry research project management, proposal preparation and administration skills will be placed. A summer school on science management for early stage researches and their participation on industrial research projects will broad their views about industry innovation and funding opportunities. A focused communication plan together with an industrial workshop will put SOLARIS in the European scene of those scientific and industrial areas. All those activities are the first step forward that will be sustained beyond the end of this project thanks to the networking and links established with the experienced partners that will open the doors to SOLARIS for future collaborations with other European and worldwide research institutions. No doubt this project aims to represent a quantum leap for SOLARIS in research and development terms.

Keywords: synchrotron,x ray absorption,spectroscopy,biology,light source,industry,users,knowledge transfer,staff exchange