Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mitochondrial membrane contact sites (MITOCHONTACTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

Organelles offer separate reaction chambers within a eukaryotic cell, thus expanding cellular metabolic capacity but necessitating mechanisms for interorganellar communication. Mitochondria are key players in cellular metabolism and their dysfunction leads to devastating conditions. Intriguingly, they are largely excluded from vesicular trafficking, creating a mystery of how they can fulfill their functions despite being cut off from these important routes of intracellular crosstalk. Membrane contact sites (CS) are starting to be appreciated as a further, vesicle independent, means of communication between organelles. CS are domains where membranes of distinct organelles are tethered by proteinaceous machineries. Factors tethering mitochondria to the endoplasmic reticulum, the vacuole/lysosome and the plasma membrane are known. Electron microscopy studies suggest existence of several additional mitochondrial CS that are currently unknown at a molecular level. Discovery of the principle of interorganellar crosstalk via CS finally offers a solution to the paradox of mitochondria as metabolic hubs being largely excluded from vesicular traffic. In order to understand how mitochondria are integrated into cellular physiology, we need to know the molecular nature of the entire repertoire of CS, their specific biological roles and their regulation in response to metabolic changes. I will utilize a systematic approach to map the complete spectrum of CS between mitochondria and any other cellular organelle in the most experimentally accessible eukaryotic model organism, the yeast Saccharomyces cerevisiae. My approach relies on creation of a molecular sensor for contact sites and its utilization in high content screens to uncover the tethers, regulators and function of mitochondrial CS. Ultimately, my goal is to build a model describing the integration of mitochondrial behavior into cellular physiology via CS-based mechanisms on a holistic level.

Keywords: mitochondria,membrane contact sites,saccharomyces cerevisiae,systematic,high content screen
Science and Innovation with thunderstorms (SAINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Spain,Spain,Germany,Norway,France,France,Netherlands,Netherlands,United States,Netherlands,United Kingdom,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-03-01
End date: 2021-08-31
Duration (months): 54.0
Total project cost (EUR): 3996874.8
EU funding (EUR): 3996874.8
Participants: 20
Project status: CLOSED

Lightning is an extremely energetic electric discharge process in our atmosphere. It significantly affects the concentration of greenhouse gases and it threatens electrical and electronic devices, in particular, when placed on elevated structures like wind turbines or aircraft, and when these structures are built with modern composite materials with inherently low electric conductivity. In addition, even our fundamental understanding of atmospheric electricity is far from complete. New discharge processes in the atmosphere above thunderstorms have been discovered, the so-called Transient Luminous Events (TLEs) in the stratosphere and mesosphere, and Terrestrial Gamma-ray Flashes (TGFs) that emit particle beams of antimatter. These phenomena demand thorough investigations, in geophysics and in the related fields of plasma and high-voltage technology where similar discharges appear. These challenges are approached within the SAINT project with a multidisciplinary and inter-sectorial training platform for 15 ESRs. The platform brings together satellite and ground observations with modelling and lab experiments. It couples scientific studies to applications relevant to industries developing satellite data products, plasma discharge technologies, lightning detection systems and lightning protection devices. With SAINT, we take advantage of the extraordinary opportunity presented by three simultaneous space missions with dedicated instruments to study lightning discharges, TLEs and TGFs, to integrate the unique space data with dedicated novel ground observations, model developments and lab experiments. SAINT will train the next generation of young, innovative scientists to shape the future of research and technology in Europe.

Keywords: atmospheric electric discharges,blue jet,gigantic jet,sprites,elves,gamma ray flash
Frontiers in Catalytic Anion-Binding Chemistry (FRICatANIONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1997762.5
EU funding (EUR): 1847281.66
Participants: 2
Project status: SIGNED

Chemical transformations comprise the polarization of the reacting species. As a consequence, partially or fully charged reagents and intermediates are omnipresent in chemistry. Although anion-binding processes are well-known for their crucial role in molecular recognition, this type of phenomenon has only recently been utilized for catalysis. Since catalytic reactions are of utmost relevance to construct valuable chemicals and materials, this mode of catalytic chemical activation might be the key for the future design of original and more efficient synthetic transformations. However, the effects of anions in catalytic processes are still largely unknown. Aiming at providing a novel general synthetic toolbox, in this project I propose several anion-binding activation concepts to solve current challenging catalytic synthetic problems. To achieve this goal, structurally different chiral anion-binding catalysts will be developed and incorporated into the existing limited palette of catalyst library. Furthermore, I propose a significant expansion of the application scope of anion-binding catalysis based on the activation and modulation of anionic nucleophiles and oxidants to develop organocatalytic reactions such as halogenations and oxidations, including the asymmetric functionalization of C-H bonds. In addition, anion-binding processes will be used to facilitate key steps in cross-coupling reactions such as the transmetallation, as well as the photoactivity modulation of readily available photosensitizers and the introduction of asymmetric photocatalysis involving radical-anions. The proposed groundbreaking approaches will revolutionize not only anion-binding catalysis but also all the scientific areas relying on catalytic synthetic methods. Thus, the results derived from this project will have a tremendous impact in diverse fields such as catalysis, organic synthesis and material sciences, as well as in economical, environmental and industrial issues.

Keywords: catalysis,asymmetric reactions
Tryst Energy: Light Energy Harvesting for the IoT-industry (Tryst Energy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The IoT sector is emerging: the amount of internet connected devices in the industrial domain is expected to increase to 25 billion in Europe within a few years. The potential of ultralow power industrial IoT starts to disrupt the industry ranging from predictive maintenance on railways, container cargo tracking to smart city sensoring. The vast majority of these devices is equipped with a battery, which results in one of the main obstacles to make a success of the IoT-revolution. The costs of the battery and battery replacement every 3 to 5 years are disproportionate to the total cost of a low power IoT-device, and therefore a major bottleneck for industry companies to start implementing IoT-ecosystems. Furthermore the battery replacement of IoT-devices results in vast amounts of chemical waste and constitutes a complex logistical challenge since a typical low power IoT-ecosystem consists in general of thousands of devices at hard to reach places TWTG R&D B.V. has developed the Tryst module, a sustainable and cost-efficient alternative for batteries by means of light energy harvesting for IoT-devices. The Tryst module harvests enough energy to continuously supply an IoT-sensor in very low light conditions, since it requires only 200 lux light for 4 hours per day. Tryst is the ideal solution since it provides IoT-energy supply which is 13 times more cost-efficient than conventional batteries and dismisses complex battery replacement campaigns. In addition Tryst reduces the projected amounts of chemical waste caused by battery usage in IoT-ecosystems. Therefore the Tryst module is the breakthrough innovation, which will make vast and growing amounts of IoT-batteries dispensable and a necessary enabler to further accelerate the IoT-revolution. To convince the market of the added value of the Tryst module a demonstration project needs to be executed. In the Phase 1 SME instrument project the preparatory actions for this demonstration project are taken.

Keywords: light energy harvesting,low power internet of things,photovoltaics,sustainable energy supply
NAtuRal instability of semiConductors thIn SOlid films for sensing and photonic applications (NARCISO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Switzerland,Sweden,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-03-01
End date: 2023-01-31
Duration (months): 47.0
Total project cost (EUR): 2592078.75
EU funding (EUR): 2588828.75
Participants: 6
Project status: SIGNED

NARCISO “NAtuRal instability of semiConductors thIn SOlid films for sensing and photonic applications” is an interdisciplinary project merging physics, chemistry, material science, fluid dynamics, and photonics with a high potential for applications and industrial scale-up of the relevant results. We propose to exploit the natural instability of thin solid films (solid state dewetting of silicon and germanium, SSD) to form complex patterns and nano-architectures (e.g. monocrystalline atomically-smooth structures, disordered hyperuniform metamaterials) that cannot be implemented with conventional methods. These patters will be used as: i) epitaxial platforms for the growth of light-emitting III-V compounds; ii) hard-masters for nano-imprint lithography of metal oxides (e.g. TiO2, SiO2, ZnO, Al2O3) deposited via sol-gel dip-coating (soft-NIL) and printed on arbitrary substrates, with tunable chemical and physical properties (e.g. composition, porosity, wettability). Methods and structures will be optimized towards their exploitation in two main domains of application: 1) photonic devices (e.g. anti-reflection coatings, colour-filters, random lasers, quantum emitters) and 2) micro-fluidic devices for bio/chemical sensing and water filtering. NARCISO holds the state-of-the-art in SSD and soft-NIL and is already at work in their theoretical comprehension their experimental implementation and practical exploitation. Now NARCISO will combine these techniques bringing them to the leading-edge of micro-and nanostructuring over ultra-large scales and with methods compatible with an industrial scale-up. The presence of the non-academic member Obducat Technologies is a strategic asset of the consortium as it is a major international actor in the nano-imprint lithography domain. It will provide the standard and needs for a realistic formulation of the relevant experimental methods and will demonstrate their implementation in a high-throughput industrial chain of production.

Keywords: patterning,solid state dewetting,sol gel dip coating,nano imprint lithography,metasurfaces
The role of ASCL1 and MYCN in human brain development (mAMBo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The evolutionary expansion of the neocortex in the primate lineage, and particularly in humans, underpins our higher cognitive abilities. Neural stem and progenitor cells (NPCs) show increased duration of proliferative phases in humans when compared to other mammals and particularly mice. However, the mechanisms responsible for these evolutionary differences in progenitor properties are poorly understood. In this study, I aim to explore the function of the ASCL1 and MYCN proteins in human NPCs. These two factors are crucial to promote proliferation in different NPC populations of the mouse forebrain, but their function in promoting proliferation of human NPCs, where they are broadly expressed, is not known. I will evaluate the spatio-temporal expression of ASCL1 and MYCN throughout human neocortical development and I will assess their cellular functions during NPC expansion using loss-of-function experiments. Finally, I will determine if ASCL1 and/or MYCN regulation have diverged between mouse and human to allow for the extended proliferative capacity of human NPCs. For this project, I will use human embryonic and fetal brain tissue and pluripotent stem cell-derived 2D neuronal and 3D spheroid cultures as in vitro models that recapitulate many aspects of human brain development. Together, this work will provide insights into the mechanisms regulating the duration of NPC expansion, a crucial parameter that underscores key differences in brain size between species, and will help to better assess the pathological mechanisms at the origin of neurodevelopmental diseases.

Keywords: neural stem cells,proliferation,human brain development,brain organoids,ascl1,mycn
Synthetic Natural Killer Cells for Immunotherapy (SYNKIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Cancer remains a leading cause of death worldwide, urging for innovative therapies. Infusion of natural killer (NK) cells, which possess an intrinsic capacity to eliminate cancer cells, is a promising treatment option for various tumours. Genetic engineering of NK cells before transfer allows to specifically tailor and modulate their anti-tumour responses. One particularly attractive strategy for broad implementation of NK cell immunotherapy in an “off-the-shelf” setting is to expand large numbers of NK cells from induced pluripotent stem cells (iPSCs). However, this approach is limited by two main bottlenecks: i) poor persistence of allogeneic iPSC-derived NK (iNK) cells due to rejection by the recipient immune system and ii) impaired functionality due to failure to achieve complete differentiation in vitro. The SYNKIT project seeks to address both of these current limitations through genetic engineering of iNK cells for increased persistence and function. Deletion of human leukocyte antigen (HLA) "self-ligands" allows the transferred cells to escape from host T cells. However, absence of HLA also triggers “missing-self” recognition and rejection by host NK cells. In addition, new insights from the host laboratory into the molecular mechanism underlying NK cell education have unravelled a pathway of functional disarming in NK cells that lack self-ligands, further diminishing the anti-tumour efficacy of HLA-deficient NK cells. In SYNKIT, I will use HLA-deficient iNK cells as a platform to assess how introduction of synthetic self-ligands modulates the allogenicity and functionality of iNK cells. The overall goal of SYNKIT is to identify synthetic self-ligands, which reduce recognition by the host immune system and yet prevent functional disarming of the engineered iNK cells, thereby resulting in optimised anti-tumour function. Successful completion of SYNKIT will pave the way for development of next generation immunotherapy to more effectively combat cancer.

Keywords: cancer immunotherapy,adoptive cell therapy,synthetic biology,molecular biology
Legitimation of Newness and Its Impact on EU Agenda for Change (LNETN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland,Sweden,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4350760.56
EU funding (EUR): 4350760.5600000005
Participants: 4
Project status: SIGNED

LNETN responds to MSCA ETN objectives and addresses the urgent need for new legitimation perspectives, theories, approaches and methods to learn and know how best to interpret and respond to newness, committing to and ensuring a positive social impact. It is the first ETN that combines newness, legitimation and theory building to address the need for training of a new generation of ESRs with quadruple-i (inter-disciplinary, inter-sectoral, inter-technology and international) and transferable knowledge, skills and broad vision. LNETN timely sets up a unique, innovative quadruple-i research and training network within social sciences and economics, with applications in science, engineering, technology, health and humanities to provide a high quality quadruple-i research platform for the training of 15 ESRs in legitimation of newness and theory building focusing on interpretation and understanding of complex phenomena in ways which will transform effective decision making and policy implementation and contribute to economic development. The overall objective and main objectives are fulfilled by the following specific research objectives: link the dimensions of sustainability to the discussion of tomorrow’s leadership and organisation, connected to a discussion of qualitative and ethical organization; generalise into a widely applicable theory/policy/practice and provide high quality research data on how new industries and ventures gain legitimation; evaluate innovative structural and operational organisational typologies and identify best practices; create a substantial, path-breaking direction for studying newness in seemingly opposing social and ethical settings. LNETN will be implemented by strong international consortium of 4 universities from Europe, 1 from US, an NGO, 4 innovative, high-technology companies and 3 innovation hubs. LNETN consortium provides for quadruple-i mobility pathways, coupled with development of research-related and transferable competences.

Keywords: legitimation,newness,theory building,new institutions,new policies,new industries,new forms of organizing,new technologies,radical innovation,sustainability,ecosystems,modern and traditional
New Generation of High Speed FIBRE SPINning machines (FIBRESPIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy,Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-10-31
Duration (months): 26.0
Total project cost (EUR): 2314766.25
EU funding (EUR): 1620336.38
Participants: 2
Project status: CLOSED

Cogne Macchine Tessili (COGNETEX) and ELETTRONICA GF (EGF)'s FIBRESPIN, is a Phase 1 winning project from the Horizon 2020 SME Instrument. The project consists of the industrialisation and commercialisation of a new technology for textile spinning machine designed for producing spools of wool/cotton fibres. Based in Imola (Italy), COGNETEX have been manufacturing high quality textile machinery for over 60 years (€4.2million revenues, 30 workers). In order to execute all necessary technological developments, our trusted collaborator, ELETTRONICA GF, an Italian hardware and software manufacturer based in Faenza (€6.2million turnover, 43 employees) has joined us in this project as our partner to develop and exclusively supply the hardware-software embedded systems in FIBRESPIN. Key stakeholders, early adopters are also present, along with an identified list of 120+ clients worldwide from our 270+ customers' portfolio. Thanks to our innovative design including the use of high-tech materials (ceramic components), an innovative electromagnetic braking system and an advanced electronic control of the whole machine, FIBRESPIN will greatly reduce maintenance downtimes as well as strongly boost productivity, outperforming existing machines (+52% outputs, -57% footprint). An important objective of this project is also to reduce the investment costs (CAPEX) for our customers. FIBRESPIN will let our clients obtain with a 624-spindle machine the same productivity that a traditional 960-spindle one reaches, which translates into more than €35,000 savings/machine. Besides, less spindles means less energy consumption. As we will see in detail, COGNETEX expects to reach 46,400 spindles sold annually by 2023, representing €8.89million revenues. As exclusive supplier of the electronic parts and systems, EGF will achieve €1.76 million annual revenues by 2023.

Keywords: spinning,spinning machine,spindle,rotor,ring traveller,wool,cotton,fibre,textile,yarn