Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIO: Banana IN and OUT - engineering resistance against Panama disease in banana (BIO-Banana IN and OUT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Panama disease is a devastating disease of banana caused by the fungus Fusarium oxysporum f.sp. cubense. A new race called tropical race 4 (TR4) is estimated to threaten >80% of the world’s bananas and can cause up to 100% yield loss. The disease is detrimental to global banana production, but also for small-holder farmers especially in Africa, because Panama disease also affects plantain cultivars that provide food for approximately 400 million people. In the 1950s, Panama Disease almost wiped out commercial banana cultivation in Central America. Because the fungus is a vascular pathogen, there is no effective way of combating the disease with crop protection compounds. In addition, the fungus can persist in the soil for many years. Traditional breeding of banana is time consuming and has had only limited success in delivering acceptable cultivars and effective resistance. The key objectives of this proposal are to employ state-of-the-arts biotechnological solutions such as genome editing using CRISPR/Cas and high-throughput resistance gene engineering to introduce a resistance gene and deactivate a susceptibility gene in banana with the global aim of creating a banana cultivar that is resistant to Panama disease.

Keywords: banana,genome editing,panama disease,fusarium oxysporum,resistance engineering,crispr,pathogen resistance,plant breeding
MagnetIc NOzzle thruster with elecTron cyclOtron Resonance (MINOTOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Belgium,France,France,France
Call: SRC - In-Space electrical propulsion and station keeping - Disruptive Technologies (H2020-COMPET-2016, 2016)
Start date: 2017-01-01
End date: 2020-07-31
Duration (months): 43.0
Total project cost (EUR): 1485809.5
EU funding (EUR): 1485809.5
Participants: 7
Project status: CLOSED

MINOTOR’s strategic objective is to demonstrate the feasibility of the ECRA technology as a disruptive game-changer in electric propulsion, and to prepare roadmaps paving the way for the 2nd EPIC call, in close alignment with the overall SRC-EPIC strategy. Based on electron cyclotron resonance (ECR) as the sole ionization and acceleration process, ECRA is a cathodeless thruster with magnetic nozzle, allowing thrust vectoring. It has a considerable advantage in terms of global system cost, where a reduction of at least a factor of 2 is expected, and reliability compared to mature technologies. It is also scalable and can potentially be considered for all electric propulsion applications, from microsatellites to space tugs. Although the first results obtained with ECRA have been encouraging, the complexity of the physics at play has been an obstacle for the understanding and development of the technology. Thus an in-depth numerical and experimental investigation plan has been devised for the project, in order to bring the technology from TRL3 to TRL5. The strong consortium is composed of academic experts to perform the research activities on ECRA, including alternative propellants, along with experienced industrial partners to quantify its disruptive advantages on the propulsion subsystem and its market positioning. ECRA’s advantages as an electric thruster technology can be a disruptive force in a mostly cost-driven satellite market. It would increase European competitiveness, help develop low-cost satellite missions such as constellations, provide end-of-life propulsion, and pave the way for future emerging electric propulsion technologies. The 36 months MINOTOR project requests a total EC grant of 1 485 809 M€ for an experienced consortium of 7 partners from 4 countries: ONERA (FR, Coordinator), industries Thales Alenia Space (BE), Thales Microelectronics (FR), SNECMA (FR), Universities Carlos III (ES) and Giessen (GE), and SME L-up (FR).

Keywords: electron cyclotron resonance,electric propulsion,thruster,plasma,satellite,disruptive,magnetic nozzle,cathodeless,microwave,propellant
The evolution of linguistic complexity (ELC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1985570.0
EU funding (EUR): 1985570.0
Participants: 1
Project status: CLOSED

Human language is unique among the communication systems of the natural world, providing our species with an incredibly flexible and powerful open-ended system of communication. This expressive power is underpinned by linguistic structure: we construct complex meaning-bearing utterances according to a set of rules and regularities which are conventionalised among speakers of a language. In my previous work I have shown that these fundamental structural features of language can be explained as a consequence of cultural evolution: structure evolves gradually as language is passed down through generations via learning and shaped by its repeated use for communication, in a process known as iterated learning. However, existing modelling and experimental treatments of iterated learning are limited in that they focus on the evolution of simple languages which permit expression of a relatively small and fixed set of concepts. Real human languages are enormously complex, both in the expressive power they afford and the rich and complex set of structural devices they provide for conveying meaning. In this project I seek to address this major outstanding question in evolutionary linguistics: why is language complex? I will tackle this daunting question by exploring two subsidiary questions: when and how does linguistic complexity facilitate acquisition, and how do expressive power and linguistic complexity evolve as a result of language transmission and use? Answering these questions will require an ambitious programme of modelling and experimental work, covering acquisition in individual adults and children, language use in interaction, and language evolution in populations. I seek to substantially advance our understanding of the cultural evolution of language by exploring how learning, expressive pressures on language use, and social complexity drive the evolution of linguistic complexity.

Keywords: language learning,language evolution,linguistic complexity,iterated learning,cultural evolution
Portugal Twinning for innovation and excellence in marine science and Earth observation (PORTWIMS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Portugal,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 997626.25
EU funding (EUR): 997626.25
Participants: 4
Project status: CLOSED

Portugal Twinning for innovation and excellence in marine science and Earth observation (PORTWIMS) will enhance the science, technology and innovation profile of the University of Lisbon, Faculty of Sciences and individual faculty staff members, through twinning with two research-intensive, internationally-leading institutes: Plymouth Marine Laboratory in the UK and Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research in Germany. It will achieve this through a combination of activities that will benefit individuals at various levels of their career from PhD students, to post-docs, to mid-career and professorial level. PORTWIMS will focus on an area of science of high relevance to Portuguese national priorities and of Portuguese support of sustainable development. The project will benefit from existing nationally or internationally funded research activities that will feed into the project. PORTWIMS will undertake collaboration and support actions to include: • exchanges of personnel and expert visits including focussing on one-to-one mentoring; • summer schools, focussing on PhD students and post-docs; • on-site training, exploiting access to expensive research cruises; • focussed training and partnership-building for preparation of research proposals to national authorities, the EC and the European Space Agency; • advice on application of outputs for policy and governance and exploitation of results to support innovation in knowledge-intensive services and products. PORTWIMS has an aim of leaving a long-term legacy of Research & Innovation enhancement beyond the end of the programme.

Keywords: marine sciences,atlantic ocean,training for excellency,scientific level enhancement,partnership building,innovation and entrepreneurship for marine services,legacy of research and innovation
From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections (iPSC2Therapy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499100.0
EU funding (EUR): 1499100.0
Participants: 1
Project status: SIGNED

Tissue resident macrophages (TRMs) can be found in various organs and fulfil important functions in host defence and tissue homeostasis. Recent studies in the murine system suggest profound tissue plasticity and self-renewal capacity of TRMs, rendering this cell population highly suitable for new cell-based therapies. Mycobacterial infections represent a serious health problem, for which new therapies are highly needed. Given the important role of alveolar macrophages (MΦs) in pulmonary host defence, I propose a cutting-edge MΦ based therapy using induced pluripotent stem cell (iPSC) technology. The unique features of iPSC will allow to investigate important regulators for the development and regenerative potential of human MΦs with the overall aim to apply these cells as an innovative treatment for pulmonary (non)tuberculous mycobacterial infections. I go beyond current knowledge and envision to enhance or exchange the endogenous alveolar MΦ cell pool by iPSC-MΦs, thereby introducing a completely new cell therapy concept. This ground-breaking cell transfer concept will have broad application potential to combat life threatening infectious diseases of the lower respiratory tract and may even be expanded to Mycobacterium tuberculosis infections. Using different knock-out iPSC lines, I will unravel important regulators for the regenerative potential of iPSC-MΦs following intra-pulmonary transfer. State-of the-art genome editing will be combined with innovative single cell RNAseq tools to understand and enhance the regenerative properties of human iPSC-MΦs. Using established cell depletion and cell transfer techniques, I will decipher the therapeutic potential of mature human iPSC-derived MΦ in vitro and in vivo using humanized mouse models and pre-clinical mycobacterial infections scenarios. The iPSC2Therapy proposal will provide an innovative anti-mycobacterial treatment with broad implications to infectious diseases and beyond.
3D experience anywhere, at any time (EXICOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The history of computing has been defined by four epochs: the mainframe, the PC, the Internet and today the smartphone. By 2020 a new era will begin, termed the blended-reality era, with six key trends will ushering this new stage: context-aware devices, health monitoring, biometric transactions, battery improvements, eyewear and display advancements as 3D displays. EXI3D is a revolutionary 3D display which allows the users to experience 3D images and videos without the need of any additional gear. EXI3D comprises a passive specially engineered polymer layer on a glass screen and an active chipset controlled by our innovative software which can create, convert and play any 3D content, supporting 4K resolution. We have integrated EXI3D in a family of products (smartphones, tablets and TVs). In this project we will complete the development and start the dissemination for the commercialization of our EXI3D products, unlocking a business opportunity expected to bring us revenues exceeding 500 M€ during the first three years in the international markets. Three main factors will drive the success of our proposal: 1) the experience of real 3D content without the need of complex or additional gear, implemented in high quality Android devices; 2) the cancelation of production of 3D products by the main companies in the sector, and the highly optimistic market forecasts; and 3) the competitive prices of the EXI3D family of products. Our business model will focus on the mass production and sale of EXI3D smartphones, tablets and smart TVs, which markets are expected to produce revenues exceeding $600Bn, $40Bn and $300Bn, respectively, by 2020. First, we need to upgrade, test and validate our current prototypes and consolidate our business plan and the associated commercial positions and resources in a two-year project with an estimated budget of 2M€. The payback period of this investment will be of less than one year of commercialization, reaching ROI=97% by that year.

Keywords: polymer layer,depth
The unique modular propulsion system suitable for all small satellites from 1 to 500 kg (IFM Micro Thruster)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Austria
Call: Engaging SMEs in space research and development (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-07-01
End date: 2019-12-31
Duration (months): 30.0
Total project cost (EUR): 1671825.0
EU funding (EUR): 1170277.5
Participants: 1
Project status: CLOSED

Several players are investing in Constellations of Satellites to provide customers services as global imaging in near real time, telephone & internet coverage, monitoring of ships, airplanes, fires etc. The global market of this new space race, worth 2.2 B$ in 2016, is expected to increase to 5.3 B$ in 2021. Many manufacturers are trying to disrupt market by lowering manufacturing costs, but the most difficult component to acquire remains the propulsion system: these satellites, in fact, work without a propulsion system, resulting in high replacement rates (once per year), limited orbit manoeuvres, difficulties in flight formation, passive deorbiting not sufficient to put satellites into graveyard orbits at their end of life. AMR propulsion aims to solve these problem with a unique, modular product: the IFM Micro Thruster, a compact, modular propulsion system suitable for all small satellites ranging 1-500 kg, with the highest propellant efficiency, capable of controlling satellites’ position with an unprecedented accuracy, perfectly suitable for single CubeSats as well as for big constellations of satellites (>100). The core, proprietary technology is based on a widely tested (13,000+ h) thruster developed for large satellite control in future ESA missions, specifically re-engineered to fit the space and mass constraints of small satellites. The thruster is based on a 2D array of porous tungsten needle-shaped emitters, capable of giving high stability and high reliability to the plasma thrust. During Phase 2 project, AMR will design and engineer the qualified model (i.e. the commercial version) of the IFM Micro Thruster; design and install an ISO-9001 certified production line, and will demonstrate and validate the technology with relevant customers. The overall goal is to reach full commercialization of IFM Micro Thruster at the end of Phase 2.

Keywords: propulsion,cubesat,satellites,thruster,mission,formation flight,constellation,indium,propellant,electric propulsion,ion source,spacecraft,aerospace,space flights,drag compensation
Handmade: Understanding Creative Gesture in Pottery Making (HANDMADE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-07-31
Duration (months): 76.0
Total project cost (EUR): 1889292.0
EU funding (EUR): 1889292.0
Participants: 1
Project status: SIGNED

Human beings have always relied on the skills of the hand for exploring their creative potential. The process of making by hand lies at the intersection between embodied cognition and material culture – linking the plasticity of the brain to the incredibly variety of bodily techniques, materials and forms of material culture. Still, the full creative dimensions of this process as well as the changing relationship of the human hand with past and present material culture are not well understood and require cross-disciplinary research. This project aims to fill this gap in our knowledge focusing on one specific material with long archaeological history and cross-cultural significance, i.e., clay and the craft of ceramics. The morphogenetic potential and plasticity of clay offers a unique kinaesthetic resource for studying the creative ecology of handmaking and exploring questions about skill, memory, distributed intelligence, material agency, tradition and innovation. Our plan is to study pottery making at first hand through sustained multi-sited participant observation in several traditional ceramic workshops spread around mainland Greece and the Islands. We will use a combination of methods from anthropology, archaeology and embodied cognitive science to record, measure, describe, compare and analyse the exact ways by which craft practitioners use their hands to produce a variety of material forms. We shall be collecting our data using extensive video recording, photography as well as through semi-structured interviews and interaction analysis. Our research procedure, grounded on material engagement theory, is designed to facilitate a heightened responsiveness to the details of action and the properties of the materials and the tools involved. Our broader aim is to use our knowledge about the creative entanglement of the hand and the clay and lay down the basic conceptual foundation for an archaeology of handmaking over the long term.

Keywords: making,material engagement,embodied,extended,enacted and distributed cognition
Innovative Reflex-based Gait Rehabilitation (INNOGAIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Stroke is the third leading cause of disability, increasingly affecting individuals at the peak of their productive life representing an enormous impact on countries’ socio-economic development. Stroke rehabilitation is estimated in approx. €4.4bn in Europe and €3.3bn in the USA. The indirect cost to society (e.g. loss of productivity) is also severe, surpassing €11.5bn in the USA alone. Gait impairment is one of the most disabling sequelae of stroke, affecting 80% of stroke survivors, leading to independence loss, decreased self-reliance and declining in patients’ dignity, also with profound effects on caregivers (therapists or relatives). This makes gait recovery a major priority in the rehabilitation program for stroke survival patients. Conventional gait rehabilitation is based on physical therapy interventions where 2 physiotherapists are needed to start the training of a stroke patient: one holding the patient and another moving the foot of the hemiplegic limb. Nordic-NeuroSTIM (NNS) is presenting Incedo (a device, an electrode and a foot sensor): a novel reflex-based technology for gait rehabilitation that in a clinical trial lead to a 20% improvement in gait speed and better gait symmetry as compared to conventional rehabilitation. This leads to increased independence and self-reliance of stroke patients, while perfectly adapts to the current clinical practice. Ultimately, Incedo reduces the number of needed physiotherapists involved in gait training from 2 to 1. NNS has successfully launched Incedo™ in Denmark with very high impact in improving gait rehabilitation of stroke patients. The INNOGAIT innovation project will boost the market entrance and launching the system all over Europe and globally, helping to position NNS as the first mover in reflex-based neuroplasticity devices significantly reducing the socio-economic burden of gait impairment due to stroke.

Keywords: stroke,gait rehabilitation,reflex based technology,neuroplasticity