Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Environmental crimes’ intelligence and investigation protocol based on multiple data sources (EMERITUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Spain,Romania,Greece,Italy,Moldova, Republic of,Austria,United Kingdom,Portugal,Belgium
Call: Fight against organised environmental crime (HORIZON-CL3-2021-FCT-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 5525062.5
EU funding (EUR): 4634193.75
Participants: 23
Project status: SIGNED

The aim of the EMERITUS project is to realize and implement a protocol for effective environmental crime investigation, leveraging on the integration of innovative monitoring and analysis technologies (drones, satellite data, virtual sensors, geo-intelligence data, etc.), and on a complementary training programme aimed at fostering environmental enforcement authorities (e.g. Police Authorities and Border Guards Authorities) intelligence and investigation capabilities, at national and cross-border level. In order to achieve this goal, the EMERITUS consortium has gathered 8 Police/Border Guard authorities from 5 countries, 4 security experts, 2 training specialists and 6 technological partners, that will be the core of the platform. The consortium will focus on the co-creation of an investigation protocol centered on environmental crimes investigation, that will orient to the creation of the geo-intelligence platform. This platform will integrate several monitoring and investigation technologies and data sources, in a single view to support Police Authorities and decision-makers. Secondly, a new training programme for Police Authorities and other security practitioners, focused on environmental (waste-related) crimes investigation and prevention, will be delivered combining both theoretical aspects and hand-on simulations to empower end-users to actually use the platform and related technologies. Such exercises will serve to validate both the platform and the protocol, via simulations based on 4 realistic use cases (heterogeneous and of growing complexity), taking advantage of the shared will of Police Authorities and Border Guards to focus on ad hoc demonstration sites, with the additional availability of partners’ simulation facilities. The validation of the platform and of the protocol will result in the successful elaboration of a set of evidence-based recommendations for policy authorities and decision-makers.

Keywords: investigation protocol,platform,satellites,drones,integration layer,lawful court proof collection of crime evidences
Next generation Limited-Angle time-of-flight PET imager (PetVision)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Slovenia,Italy,Spain,Germany,United States,Switzerland
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 3374041.25
EU funding (EUR): 3374041.0
Participants: 9
Project status: SIGNED

Over 2.7 million people in the EU were diagnosed with cancer in 2020, while 1.3 million people lost their lives to it. Cancer cases are predicted to increase by 24% by 2035, making it the leading cause of death in the EU. The current leading specific molecular imaging diagnostic technique sensitive to cancer is based on Positron Emission Tomography (PET). Due to the high implementation cost of PET, this high-sensitivity diagnostics, is only available to less than 0,5 % of the medical centers in the world. The critical component of the overall cost is the cost of PET scanners. Our project proposes a radical vision to translate European breakthrough technological advances in Time-of-Flight PET detection to a revolutionary, fully modular, cost-accessible flexible family of devices for applications from the standard PET center to the surgery, epilepsy clinics, intensive care units and even emergency rooms and in mobile units installed in vans. The proposed PetVision project aims to develop a simple pilot demonstrator, a modular panel PET device with a coincidence timing resolution of about 75 ps FWHM, close to the intrinsic timing limit of currently available PET scintillators. This resolution is several times better than the current gold standard of 214 ps FWHM achieved with the current clinical state-of-the-art device (Siemens Biograph Vision). With such excellent timing, the panel detectors can cover only a limited solid angle to reach the same sensitivity or improve the sensitivity in the case of a total-body imager. For the realization of the device, a package of breakthrough innovations in detector design, photo-sensor, and front-end electronics are planned. We expect that the proposed device will dramatically impact human health.

Keywords: medical instrumentation,time of flight pet,todal body pet,limited angle coverage
Does population size structure affect larval viability in marine fish? Insights into maternal investment using stable isotopes (POPULAV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

One of the most pervasive effects of decade long overexploitation of marine fish is the truncation of size distributions in affected populations. Today, many populations of commercially important species, such as Atlantic cod (Gadus morhua), consist of smaller individuals than just a few decades ago. Concurrently, a general decline in recruitment has been observed with severe consequences for population growth and productivity. These observations have led to the formulation of the Big Old Fat Fecund Females (BOFFF) hypothesis, which states that older, larger females contribute disproportionally more to the recruitment because of their increased mass-specific fecundity and production of more viable offspring. The first part of the hypothesis has been tested and confirmed, while the considerably more challenging test of superior offspring survival is hindered by the inability to link individual offspring caught in the open sea to the size of the mother. In the POPULAV project, I will use size-specific natural biochemical markers (stable isotopes) to link maternal size to larval viability. Larvae are provisioned with the maternal isotopic signature via nutrient transfer from maternal gonads to the eggs/larvae; A promising, novel tool to provide a robust test of the BOFFF hypothesis. The objectives are to (1) confirm the size-effect on maternal gonadal isotopic signature, (2) assess size-dependent stable isotope transfer in laboratory experiments, (3) assign wild-caught larvae to the size of its mother using stable isotope profiles, and (4) use a simple model to estimate the effect of population size truncation on larval viability. Data obtained in POPULAV will advance our understanding of how size truncation affects larval viability and thereby recruitment. This knowledge can support decision making and fisheries management, and place its coordinators and the EU at the forefront of international efforts for understanding the impacts of fishing on our marine resources.

Keywords: maternal provisioning,larval quality,biochemical markers,atlantic cod,fish ecology
Enabling comprehensive effective and efficient protection and restoration measures for a resilient Baltic Sea ecosystem (PROTECT BALTIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Finland,Denmark,Sweden,Germany,Lithuania,Estonia,Latvia
Call: European Blue Parks – Protection and restoration solutions for degraded coastal and marine habitats (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-08-15
End date: 2028-08-14
Duration (months): 60.0
Total project cost (EUR): 8500018.75
EU funding (EUR): 8481917.0
Participants: 20
Project status: SIGNED

The EU Biodiversity Strategy (BDS) requires expanding the spatial coverage of marine protected areas to 30%, with 10% strict protection. Achieving the current 14-17% coverage has taken the Baltic Sea region 30 years, and strict protection remains almost non-existent. To meet the BDS target the countries will have to double the coverage in just 8 years. To fully capitalize on the added value of increased coverage, designation, management and measures, including restoration, need to be done in a strategic, ecologically relevant way focusing on areas and measures which enhance the existing network and optimise the possibility to secure positive biodiversity outcomes. There are however substantial challenges facing the region when it comes to leveraging the full potential of upcoming protection and restoration efforts and ultimately, positive biodiversity outcomes, especially in such a tight timeframe. To ensure that the upcoming efforts are both effective and efficient, this transboundary, network level, biogeographical region scale project will: - develop infrastructure for, and ensure long term access to, an unparalleled data driven, ecoregion scale, evidence base to support strategic planning, measures and management; - develop a blue print for, and establish, a data driven, regionally agreed protection framework to improve governance and transboundary cooperation, including politically agreed shared conservation and restoration objectives, targets etc to reach the desired state; - identify the current baseline of protection efforts across the entire sea basin. - cross-reference the desired state with the current baseline to identify gaps in protection and restoration efforts; - provide concrete and replicable support to ensure capacity for the Baltic Sea MS to strategically fill the gaps, harmonise, and achieve the full potential of the protection and restoration efforts.

Keywords: mpa,restoration,governance,management,designation,protection framework
Unveiling the role of histone marks in metabolic memory storage and transmission. (HISTORABLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Type 2 diabetes (T2D) is a multifactorial disease affecting over 450 million people in Europe alone, amounting to the burden of life-threatening diseases and worsening quality of life. Skeletal muscle is affected early in T2D and contributes to the fast decline of whole-body glucose homeostasis, which is called insulin resistance. Interestingly, even when isolated from the body and cultured in a laboratory in non-diabetogenic conditions, the skeletal muscle cells do not lose the characteristics of the donor, i.e., the cells remain insulin resistant, indicating the existence of a cell-autonomous mechanism that retains the metabolic memory across generations of cells. Nonetheless, such a mechanism remains elusive. Accumulating evidence suggests a potential role of histone post-translational modifications as essential vectors of inheritable information, but it is still a matter of intense debate. In this project, to address this question and understand the pathology of T2D, we will trace a comprehensive genome-wide map of histone post-translational modifications induced by T2D in human primary skeletal muscle cells and investigate whether these histone marks can store and transmit information about the metabolic phenotype from the donor to the next generation of cells. Targeted studies using pharmacological and genetic interventions will then address the role of histone modifying enzymes in metabolic memory transmission. The outcomes could lead to a novel understanding of a broader system of cellular memory storage and transmission. By characterizing the disturbances caused by diabetes in the epigenome using state-of-the-art techniques and multidisciplinary approaches, we could pave the way for innovative clinical interventions addressing a critical global health challenge.

Keywords: epigenetic regulation of metabolic flexibility and inheritance in the skeletal muscle
salt HYdrate Heat Pipes; a breakthrough in thermal energy transfer methods (HYHP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

Heat pipes (HPs) are one of the highly efficient passive devices used for heat transfer from one place to another. Recent HP technologies have shown auspicious results in several applications, especially where there is limited space and the necessity of high heat flux, such as in aerospace and automotive industries, cooling of computers, cell phones, fuel production, HVAC systems, and renewable energy systems. Although HPs offer acceptable ranges of thermal efficiencies today, achieving higher efficiencies could make a revolution in their applicability, making them a dramatically more effective tool for the mentioned applications and even many others. Hence, this project proposes a first-of-its-kind and revolutionary approach for the performance enhancement of heat transfer tools, especially in HPs. The method centers around the use of salt hydrate (SH) materials with positive enthalpy of dissolution as the working fluid. The project pursues several specific research objectives, including 1) developing the first SH-HP using the primary choice material of NH4NO3, 2) finding and testing potential alternatives for the benchmark material, 3) thermal and flow simulation (CFD) of HPs (in various designs) with the selected materials as working fluid, 4) thermal behavior optimization of the SH-HPs, 5) experimental verification of the modeling results on the SH-HPs in the lab, and 6) carrying out a risk analysis, life cycle cost, and life cycle assessment of the developed HPs. It is expected that the enhancement to be made in HPs’ design and performance could be advantageous for a wide range of thermal energy systems, especially those for the exploitation of renewable energy e.g., geothermal systems, solar evacuated collectors, etc.

Keywords: heat pipe thermochemical material endothermic materials heat transfer system level optimization life cycle assessment computational fluid dynamics
Adaptation to Climate Change in Developing countries (ClimateAdapt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1565511.25
EU funding (EUR): 1565511.0
Participants: 2
Project status: SIGNED

The fast pace at which the earth climate is changing is one of the major challenges of our time. Rising temperatures are expected to reduce agricultural productivity in developing countries, which face uncertain adaptation paths. The theoretical literature highlights two potential adjustment mechanisms: the reallocation of economic activity towards non-agricultural sectors or towards colder regions. In the first case, lower agricultural productivity generates a shift in comparative advantage towards non-agricultural sectors and a reallocation of workers from agriculture towards manufacturing and services. However, this path might not be feasible for regions with low manufacturing productivity. In this second case, the lack of local employment opportunities can lead to migration towards other areas. There is a rich theoretical and quantitative literature studying the relative importance of each margin of adjustment. However, these predictions are subject to a large level of uncertainty due to the lack of direct empirical evidence. In particular, we lack evidence on how labor and capital market frictions shape the adjustment to climate change. We are now in the position to produce this evidence. The last decade has been unusually hot, leading to many persistent extreme weather events in tropical countries, which triggered adaptation responses. In this project, we use newly digitized administrative reports on extreme weather events occurred in Brazil during the last two decades, a new meteorological measure of excess dryness relative to historical averages, and detailed social security and credit registry data to estimate the effects of climate change on i) the local economy of affected areas, ii) the magnitude of the labor and capital flows it generates and iii) factor allocation across sectors and firms in destination regions.

Keywords: climate change,agricultural productivity,structural change,migration
Triaxial stresses, anisotropic damage, and directional fluid flow across scales (TRIFLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-15
End date: 2026-11-14
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

The ability to accurately predict both the magnitude and direction of fluid flow within fractured rocks is paramount for the secure injection of fluids into the subsurface—an essential operation for geothermal energy production and CO2 storage. Even though the stress conditions at depth control the creation of fractures and the transport of fluids through them, technical difficulties have impeded the replication of crustal conditions in the laboratory, and the knowledge of fracture development comes primarily from experiments conducted under simplified two-dimensional stress conditions. This limited perspective has restricted the understanding of the interplay between three-dimensional stresses, the geometry of developed fracture networks, and the direction of fluid flow within fractured rocks. Furthermore, a key challenge for large-scale fluid flow prediction is the extrapolation of results obtained at the laboratory scale (centimetres) to actual reservoir scale (hundreds of meters to kilometres). This project, TRIFLOW, will use for the first time a novel apparatus to deform samples under representative crustal conditions to establish how 3D stresses influence fracture geometry and directional permeability. These results will be combined with innovative 3D mapping methods applied to natural examples of fossilised fluid flow in the form of vein networks, and numerical analyses, to study the dynamics of tridimensional fluid flow across scales. The outcomes of this project are expected to bring substantial advancements to our comprehension of fluid flow dynamics under genuine crustal conditions. This improved understanding will, in turn, enhance the precision of fluid flow simulations for applications involving the injection of fluids into fractured rocks, thereby contributing to the safety of processes such as geothermal fluid injection for energy generation and CO2 storage, both of which are crucial solutions for reducing greenhouse emissions to the atmosphere.

Keywords: fracture permeability fluid flow rock mechanics rock physics brittle deformation mechanical anisotropy fractured media
expressTEC - From Launch to First MVP (expressPIK)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Over 600k annual new cases of breast cancer worldwide carry poor prognosis mutations in the gene PIK3CA, but since 2020 a targeted therapeutic option – PIQRAY (alpelisib) – became available, exclusively from Novartis. However, due to the still unsatisfactory response rates, the uptake by doctors and the adherence by patients has been limited. Eligibility is established at present by assessing the PIK3CA status in tumour DNA via companion diagnostic (CDx) tests (from Qiagen and Roche). However, we found that the level of expression of the PIK3CA mutations, measured in tumour RNA, associates with prognosis and is more accurate to predict the presence of the final mutated protein (the drug target). Hence, we are developing an innovative CDx – expressPIK - that goes beyond the present ones to test the expression of mutations and correctly identify the patients who will benefit from treatment. Our higher accuracy will increase doctors’ confidence in prescribing expressPIK (profitable for expressTEC and investors), and the better response rate (beneficial to patients) will promote patient uptake and treatment adherence (profitable for Novartis). The total global expressPIK market is over +600 K patients per year. The European Patent pending secures the use of mutation expression levels in clinical diagnosis, for treatment with PIQRAY and other drugs in clinical trials. We are validating the technology and planning to reach the MVP within a year. Women TechEU will support developing our business knowledge and acumen, as well as provide the access to the industry and investors network we are lacking. We hope to make a change in the survivorship of breast cancer patients, whilst setting an example of female entrepreneurship in a region with high unemployment and low biotech investment.

Keywords: breast cancer,in vitro diagnostic,personalized medicine,rna