Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human-Mosquito Interaction Project: Host-vector networks, mobility, and the socio-ecological context of mosquito-borne disease (H-MIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1960828.0
EU funding (EUR): 1960828.0
Participants: 1
Project status: SIGNED

This project will use mobile phone positioning, DNA fingerprinting, and citizen science, combined with traditional socio-demographic methods to trace the host-vector biting networks through which mosquito-borne diseases flow and illuminate the behavioural, socio-demographic, and environmental mechanisms that shape these networks in a spatially explicit manner. It will merge this ground-breaking data with existing datasets on population, urban structure, land cover, and climate, analysing it using network techniques, spatial models, and machine learning to test hypotheses about the determinants of these networks. The results will make it possible to improve dynamic models of mosquito-borne disease and recommend targeted policy interventions for reducing disease risk in Europe and around the world. In doing so, it will address the critical need for greater social science perspective iThis project will use citizen science, mobile phone geo-localization, genetic analysis, surveys, interviews, and cutting-edge modelling techniques to trace the host-vector contact networks through which mosquito-borne diseases flow, illuminate the mobility patterns and other behavioural mechanisms that shape these networks, and evaluate policy interventions aimed at reducing the risk of these diseases in urban and suburban settings. In doing so, it will address the critical need for greater social science perspective in mosquito-borne disease research, making it possible to improve disease models and public health management through a fuller understanding of the socio-ecological context driving dengue, chikungunya, Zika and other mosquito-borne diseases that place enormous burdens on society and exacerbate social inequality across the globe. It will draw on the the PI’s unique interdisciplinary background, straddling socio-demography, public policy, and disease ecology, and his pioneering work on citizen science in public health research and mobile phone tracking in demographic research.

Keywords: socio ecology,disease ecology,citizen science,vector borne disease,disease vector mosquitoes
Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy (EpiViral)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Netherlands,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 878446.25
EU funding (EUR): 878446.25
Participants: 4
Project status: SIGNED

The Universidade de Aveiro (UAVR) is widely recognized as one of the most innovative universities in Portugal. Its research activities are carried out by 20 research units (RU) covering diverse scientific areas. The Institute of Biomedicine (iBiMED-UAVR), one of UAVR’s most recent RU, is ranked among the top 5 research institutions in the biomedical field in Portugal. However, progress is mainly affected by low national funding availability and access to cutting-edge resources and infrastructures. This Twinning proposal (EpiViral) was set on the strategic vision of iBiMED-UAVR to boost the scientific excellence of its young researchers in the fields of virology and epitranscriptomics, which are underrepresented at the national level. To achieve this, EpiViral’s strategy relies in 5 main pillars: 1) Boost research excellence of iBiMED-UAVR in the fields of virology and epitranscriptomics, by implementing joint research projects; 2) Stimulate the innovation capacity of iBiMED-UAVR and contribute to new joint teams of highly-skilled researchers; 3) Promote and enhance networking and international awareness of iBiMED-UAVR research and achieve broad societal impact for virology and epitranscriptomics research; 4) Promote the establishment of links with industry based on the experience and best practices of the two leading partners; and 5) Create an advanced and sustainable virology and epitranscriptomics research network for further cooperation. We believe EpiViral Twinning project will allow iBiMED-UAVR researchers to thrive in the cutting-edge field of epitranscriptome modulation in the context of viral infections, by potentiating a network which has the ideal expertise and know-how to achieve its objectives. EpiViral will thus assertively project iBiMED-UAVR as a European research organisation of excellence in the virology field.

Keywords: virus,epitranscriptomics,trna,trna modifying enzymes,virus host interactions,antiviral innate immunity
Hydrogen In Gas GridS: a systematic validation approach at various admixture levels into high-pressure grids (HIGGS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Germany,Spain,Spain,Switzerland,Belgium
Call: Systematic validation of the ability to inject hydrogen at various admixture level into high-pressure gas networks in operational conditions (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 2107672.5
EU funding (EUR): 2107672.5
Participants: 7
Project status: SIGNED

The new policies and the revised renewable energy Directive are fixing ambitious targets for 2030: renewable energy target of at least 32% and an energy efficiency target of at least 32.5%. When the policies are fully implemented, they will lead to a great reduction on emissions for the whole EU, around 45% by 2030 (relative to 1990 GHG emission). The EU framework towards GHG emissions reduction is based in six key areas of action, including the deployment of renewable energy production, decarbonising heating and cooling applications (which vastly relies on fossil fuels), and reducing the emissions on the transport sector. Therefore, the integrated energy markets in the EU shall allow important transformations to provide more flexibility and be better placed to integrate a greater share of renewable energies, allowing also a more independent energy system. In this context, Hydrogen can play a pivotal role as energy vector allowing coupling the energy sectors (produced by electrolysis) , and as an alternative fuel in hard to electrify sectors. To facilitate that a high amount of hydrogen is produced by RE, existent gas infrastructure could be a way of transporting hydrogen between production point and final use. Therefore, hydrogen injection into the gas grid could support gas-electricity sector coupling and opening the role of hydrogen as a way of decarbonising the gas usages. HIGGS project aims to pave the way to decarbonisation of the gas grid and its usage, by covering the gaps of knowledge of the impact that high levels of hydrogen could have on the gas infrastructure, its components and its management. To reach this goal, several activities, including mapping of technical, legal and regulatory barriers and enablers, testing and validation of systems and innovation, techno-economic modelling and the preparation of a set of conclusions as a pathway towards enabling the injection of hydrogen in high-pressure gas grids, are developed in the project.

Keywords: admixture,h2 injection,power to gas,gas network,gas transmission
“Diagnosis of Ischemic Heart Disease by means of innovative and highly accurate high frequency QRS electrocardiogram analysis” (HYPERQTOTAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Occlusion of the coronary arteries that supply oxygenated blood to the heart muscle is referred to as ischemic heart disease (IHD). IHD is the most common, serious, chronic, life-threatening illness in the developed world. Currently, the most widely used tool for diagnosing IHD is the electrocardiogram (ECG), which records the electrical activity of the cardiac muscle as it generates the stages of the cardiac cycle. Specific changes in the ECG recorded during physical stress protocols are used for the non-invasive detection of IHD. Patients with positive stress test results are usually referred for further investigation. However, the sensitivity of the standard ECG, even during stress tests, is relatively poor, and is generally considered to be between 50% and 70%, and in some studies has been reported to be even lower. That, in other words, means that 30-50% of all IHD patients are not diagnosed correctly by standard stress ECGs. Traditional ECG analysis is performed in the 0.05 – 100Hz frequency range. However, a significant body of evidence accumulated during recent years indicates that higher frequency spectral components of the ECG signal contain valuable information for the detection of IHD. Studies published by Prof. Shimon Abboud, BSP’s chief scientist, and Dr. Amir Beker, BSP’s founder and CEO, have shown that the presence of ischemic pathologies in the heart is highly correlated with specific changes in the high-frequency spectral components of the ECG. BSP has pioneered the clinical implementation of high-frequency ECG and has developed it into a valuable diagnostic application. The company’s proprietary HyperQ™ technology extracts and analyses the high-frequency components of the ECG. BSP has pursued the development of its HyperQ™ technology in two parallel, highly correlated, pathways: (a) acquisition and reliable production of the HyperQ™ signal, and (b) analysis of the HyperQ™ signal for extracting clinical and diagnostic information.

Keywords: stress ecg,high frequency,biomarker,ischemia
Uncovering the genomic underpinnings of the convergent evolution of a major social trait (ConvergeAnt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-04
End date: 2022-02-25
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Understanding how complex traits evolve repeatedly across species remains a major challenge in biology. The number of queens in an ant colony is an important trait associated with queen lifespan and fecundity, dispersal strategies, and responses to environmental stimuli. Although colonies of most ant species have either one or multiple queens, more than twelve ant species have evolved social dimorphism: co-existence of single- and multiple-queen colonies in a population. This phenomenon presents a remarkable opportunity to discover mechanisms of convergent genetic evolution. Our proposal takes advantage of the recurrent evolution of social dimorphism in ants to understand the genomic basis of this complex trait. Recent genomic studies have revealed that a “supergene” genomic region including hundreds of linked genes determines colony type in two distantly related ant species. However, it remains unclear to what extent supergenes underlie social dimorphism and which genes are important for the evolution of this trait. Here, we aim to elucidate general principles governing the evolution of social dimorphism at the molecular level. We will select six ant lineages in which the co-existence of the two social forms has independently evolved to accomplish three goals: 1) test whether supergenes are required for dimorphic social organization by performing genome-wide comparisons between single- and multiple-queen colonies; 2) test for similar changes in gene content or sequence across the independent origins of social dimorphism by comparing phylogenetic profiles; 3) determine whether differences in gene expression in workers of single- versus multiple-queen colonies are consistent across species by performing transcriptome-wide comparisons. Our project will provide major insights into the genetic architectures and pathways underpinning the evolution of social dimorphism, and will substantially improve our understanding of the evolution of complex phenotypes.

Keywords: social insect,genomics,transcriptomics,social polymorphism,polygyny,bioinformatics
Inspiring to Create (I2C8)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain,Austria
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2016)
Start date: 2017-05-01
End date: 2018-04-30
Duration (months): 12.0
Total project cost (EUR): 99937.5
EU funding (EUR): 99937.5
Participants: 2
Project status: CLOSED

I2C8 will start from the successful research carried out during the Lrn2Cre8 FET project and bring it closer to market, by exploiting results related to creativity and automatic music generation technologies. I2C8 will develop a new product for music chord generation and randomization, with intelligent and automatic features, aimed at the music production market. I2C8 will empower electronic musicians, producers and DJs to enrich their creative palette and have a tool for interactive inspiration in their music-creation process by providing a ‘musical sketchpad’ able to quickly record musical ideas with the assistance of intelligent music algorithms. Objective of I2C8 is to develop a product ready for market launch. Therefore, two main streams of activities will be carried out: 1. Integration and consolidation of relevant technologies (both developed during the FP7 project and owned by partners) into a standalone product, incorporating user-informed and market-generated requirements; 2. product development and market push activities. These two streams of activities will be tightly integrated by adopting an iterative development process and fit within the objectives of the FET Launchpad. The project will include two of the Lrn2Cre8 partners: RECO and EHU. RECO will lead the project, being an SME already selling successful music-creation software and with a strong user/market base. EHU, which is an International Excellence Research Campus in Spain, will provide the technical expertise and continuity with the key research topics carried out during the FET project.

Keywords: automatic music generation,intelligent music algorithms,creativity,music production,composition,chord sequences,harmony,machine learning
Cross-talk between platelets and immunity - implications for host homeostasis and defense (IMMUNOTHROMBOSIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2321416.0
EU funding (EUR): 2321416.0
Participants: 1
Project status: SIGNED

The overall aim of the IMMUNOTHROMBOSIS project is to clarify the mechanisms underlying the recently identified synergism between thrombosis and inflammation. Thrombus formation and inflammation are vital host responses that ensure homeostasis, but can also drive cardiovascular disease, including myocardial infarction and stroke, the major causes of death in Europe. My group and others discovered, that thrombosis and inflammation are not to be considered separate processes. They are tightly interrelated and synergize in immune defence, but also in inflammatory and thrombotic diseases in a process we termed immunothrombosis. Targeting this synergism has great potential to identify innovative and unconventional strategies to more specifically prevent undesired activation of thrombotic and inflammatory pathways. However, this requires a deeper mechanistic understanding of immunothrombosis. I recently identified two ground-breaking novel immunothrombotic principles: I discovered that platelets have the ability to migrate autonomously, which assists immune cells in fighting pathogens. Further, I revealed that immune cells play a central role in controlling the production of platelets from their megakaryocyte precursors. The physiological and pathophysiological relevance of both processes is unclear. This is the starting point and focus of the IMMUNOTHROMBOSIS project. My aim is to define how platelets use their ability to migrate to support immune cells in protection of vascular integrity (objective 1) and to identify the contribution of platelet migration to different cardiovascular diseases involving immunothrombotic tissue damage (objective 2). Finally, I will clarify how inflammatory responses feedback to the production of thrombotic effectors and dissect inflammatory mechanisms that control platelet production (objective 3). IMMUNOTHROMBOSIS will identify new options for specific prevention or treatment of thrombotic and inflammatory cardiovascular diseases.

Keywords: thrombosis,inflammation,haemostasis,platelets,innate immunity
MSCA 2020 - Achieving more together (MSCA DE 2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Coordination and support actions
Countries involved: Germany
Call: Presidency conference (H2020-IBA-MSCA-DE-Presidency-Conf-2020, 2020)
Start date: 2020-08-01
End date: 2021-05-31
Duration (months): 10.0
Total project cost (EUR): 112500.0
EU funding (EUR): 112500.0
Participants: 1
Project status: CLOSED

The second half of 2020 is a crucial time for Research and Innovation in Europe. The new framework programme "Horizon Europe" will start in 2021 (though the start depends on an agreement of the multi annual financial framework, nevertheless, this agreement should be reached during the German presidency), and with it a new seven year span of the MSCA. Moreover, new initiatives in the European research and education landscape have just started with the "European Universities Initiative" probably as their most prominent one. The MSCA German Council Presidency Conference “MSCA 2020 – Achieving more together” will address different MSCA topics embedded into greater political contexts. The focus will be on: 1. MSCA and European Universities: As for the ERA, council conclusions on the European Universities Initiative are planned for November 2020 during the German Presidency. The German MSCA conference seems to be the right place to draw the first conclusions of this initiative and to determine wishful synergies. 2. Supervision in MSCA: We would like to put the focus on the highly important, but so far neglected group of supervisors in MSCA, and shed light on their challenges. Written guidelines for good supervision shall be a result of the conference, which will be done in a working group to be initiated in 2020.

Keywords: msca,european research area,horizon europe,supervision,science communication,european universities
Mapping Nanoscale Charge Separation at Heterojunctions with Ultrafast Electroabsorption Microscopy (NanoEAscopy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Nanostructured electronic materials e.g. organic semiconductors (OSCs) and 2D semiconductors offer great promise for applications in optoelectronic (OE) devices, such as photovoltaics (PVs), light emitting diodes (LEDs) and photodetectors. The primary photoexcitations in both OSCs and 2D semiconductors are strongly bound excitons, quasiparticles of electrons and hole bound by the Coulomb interaction. Three aspects of these materials stand out when attempting to study photophysics of these materials. (1) Many of the crucial OE process in these systems occur at heterojunctions between p- and n-type materials, where charges recombine to form excitons and excitons dissociate to form charges. (2) The timescale for many such process is sub-ps, and charge transfer and charge separation (CS) can occur on sub-100fs timescales. (3) thin films made of these materials possess spatial inhomogeneity on µm and sub-µm length scales, due to variations in molecular packing, crystallinity and phase segregation in OSCs and due to lattice defects and variation in surface passivation and strain in 2D materials. No currently available technique has the ability to spatially correlate transient spectroscopic data with local molecular structure and composition. In order to do this, we will develop a new platform to directly image CS with sub-10fs time-resolution with sub-µm spatial resolution. Recent advances in pump-probe microscopy and ultrafast Electro-Absorption (EA) spectroscopy in the host’s group will be combined with the applicant’s expertise with optical microscopes and advanced data analysis methods to detect and quantify inhomogeneity. Novel analysis methods combined with an ultrafast EA pump-probe microscopy will allow for correlation of transient spectroscopic data with local molecular structure and composition. This will lead us to elucidate how CS is controlled by local properties such as molecular packing and crystallinity in OSCs and defect sites etc. in 2D semiconductors.