Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Groundwater flow CONtrols on CRitical zonE ThErmal Regime (CONCRETER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1499830.0
EU funding (EUR): 1499830.0
Participants: 3
Project status: SIGNED

The foundations of modern hydrogeology have been built within the paradigm of quasi-equilibrium temperature distribution within groundwater systems. The presumed thermal stability of groundwater is vitally important for many groundwater and stream ecosystems which cannot tolerate a wide temperature range and face growing threats from climate and land-use changes. Yet, recent results evidenced the great impact of ongoing atmospheric warming on shallow groundwater temperatures. Groundwater flow is expected to strongly affect groundwater and stream warming trends. A major issue is that existing modeling frameworks have largely sidestepped (1) the complexities associated with the multi-scale heterogeneity in groundwater flow, and/or (2) the transient nature of groundwater fluxes and surface temperature. Furthermore, direct field evidences of the impact of climate and anthropogenic forcings on the temperature distribution are still rare. The CONCRETER will therefore assess the role of groundwater dynamics in shaping the thermal regime of the critical zone, the shallow subsurface where the water, element, energy and biological cycles interact. The focus on the interaction of subsurface heterogeneity with heat transport processes will require the development of original numerical models (WP1) and novel temperature imaging laboratory experiments (WP2). WP3 will bring critical in situ data to constrain these newly developed models. WP4 will further develop advanced numerical models to separate the effects of fluid flow and of surface warming. With the help of the developed numerical approaches, WP5 will study the evolution of temperature at field sites (characterized in WP3) chosen to isolate the role of different forcings (climatic, anthropogenic) on critical zone thermal regime. CONCRETER will provide new physical frameworks and modelling tools for multi-scale heat transport processes in the critical zone, with the potential to re-define their quantitative understanding.

Keywords: heat transport,fractured media,groundwater flow,flow channeling,thermal dynamics,borehole climatology,monitoring,sensing,modelling,geothermal energy
From youthful vigor to maternal wisdom: signaling pathways in oocyte aging (FRASP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

In developed countries, modern lifestyle often leads women to postpone their decision on when to have children. By 2022, the average age at which women in Europe give birth to their first child had crossed 30. Unfortunately, delayed motherhood is associated with a decline in women's reproductive potential, which can manifest as difficulties with conception, miscarriages, or an increased risk of delivering a child with chromosomal abnormalities. This decline is primarily attributed to the fact that oocytes, the reproductive cells, gradually lose their quality and fertilization potential with age. The primary object of the FRASP (Female Reproductive Ageing - Signalling Pathways) Proposal is to gain insights into why oocytes lose their reproductive capacity as women age. Recently, several signalling pathways have been identified to be involved in the aging of oocytes and the cumulus cells that directly surround and interact with them. However, our current understanding remains limited, and this knowledge may not have an immediate impact in the near future. This Proposal aims to comprehensively analyse the signalling pathways responsible for aging in oocytes and cumulus cells derived from mice. To achieve this, we will employ a range of high-throughput techniques comprising for multiOMICS approach. Signalling pathways will be investigated at the RNA, protein, and metabolite levels. Additionally, we will explore how these pathways influence the outcome of fertilisation. We believe that our approach will provide a profound understanding of the intricate molecular mechanisms that occur during oocyte aging, ultimately offering potential molecular targets for therapeutic interventions.

Keywords: reproductive aging,advanced maternal age,oocyte aging,cumulus oocyte complex,signalling pathways
Deep Label-Free Cell Imaging of Liquid Biopsies for Cancer Monitoring (LF-LB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We will develop and commercialize an innovative device for diagnosis and monitoring of cancer in liquid biopsies based on a label-free interferometric phase microscopy (IPM) unit, coupled with dedicated real-time artificial intelligence (AI) for cell classification. This device will materialize an innovative approach for the much-anticipated imaging flow cytometry, dramatically decreasing its costs, and improving patient care by accurate monitoring of cancer in the clinical lab from a simple lab test (liquid biopsy). The success of the project is dependent on four high-risk/high-gain aspects: (a) Building the first clinical IPM device. (b) Designing and manufacturing a disposable microfluidic device for imaging flow cytometry. (c) Obtaining high-enough acquisition and processing throughput in imaging flow cytometry of urine samples. (d) Training a deep natural network to detect cancer cells based on the information-deep label-free IPM images of cancer cells during flow. The proposed PoC project stems from my on-going ERC StG project that focuses on the application of IPM for grading the metastatic potential of cancer cells, as a basic-science research tool.
Personalised blueprint intestinal health (miGut-Health)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Switzerland,Lithuania,Netherlands,Israel,Italy,Sweden,Denmark,Croatia
Call: Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7131243.75
EU funding (EUR): 7126243.75
Participants: 13
Project status: SIGNED

The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management. Taking on this mission, miGut-Health pursues the following strategic goals: - To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients. - To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD. - To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals. - To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets. - To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status. - To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.

Keywords: inflammatory bowel disease,gut inflammation,gut health,patient empowerment,ehealth,health status monitoring,health to disease transition,early clinical symptoms of ibd,omics,nutrition
Understanding the Demography and Stratification of Singlehood in Europe (SINGLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1497563.0
EU funding (EUR): 1497563.0
Participants: 1
Project status: SIGNED

Amid declining marriage and fertility rates, singlehood is rapidly gaining scholarly attention. Yet, singlehood scholarship is remarkably fragmented and underdeveloped. Existing theories are divided between narratives of singlehood as an unfavorable outcome or an empowering life choice. Moreover, existing frameworks are limited by a glaring inconsistency in the measurement of singlehood, an overwhelming focus on young adults, and a general neglect of cross-national and intersectional approaches. These limitations undermine our ability to establish a comprehensive, holistic framework that answers fundamental questions: (1) what the scope of singlehood is in the adult population and (2) how social stratification is reproduced within the single population. SINGLE proposes to resolve these tensions by taking an unprecedented, comprehensive, comparative approach that bridges demographic and sociological debates and pays attention to the diverse challenges and opportunities that single life offers. First, SINGLE takes a population approach by establishing a Demography of Singlehood framework that will produce and disseminate estimates of the prevalence, composition, and duration of singlehood across Europe using various large-scale secondary data sources. Through novel data collection, SINGLE will also offer pioneering insights into singles’ self-identification and motivation to be single to improve our understanding of selection and terminology in singlehood research. Second, SINGLE takes a stratification approach to expand our understanding of social inequality within the single population. SINGLE will disentangle how demographic, economic, and cultural forces systematically shape singles’ unequal outcomes within and across countries. By documenting singles’ time use, well-being, perceived pressure to partner, and access to support systems, SINGLE will reframe our knowledge of the complexity and diversity of European singlehood.

Keywords: singlehood union formation family demography cross national social inequality
Cyber-security Excellence Hub in Estonia and South Moravia (CHESS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Estonia
Call: Excellence Hubs (HORIZON-WIDERA-2022-ACCESS-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4999962.5
EU funding (EUR): 4999962.5
Participants: 13
Project status: SIGNED

The proposed Cyber-security Excellence Hub in Estonia and South Moravia (CHESS) will integrate leading cybersecurity institutions and capitalize on the strengths of both regions to address important Europe-wide challenges. South Moravia is a major ICT industry & education powerhouse of the Czech Republic, with a very focused and coherent smart specialization strategy targeting cybersecurity. Estonia is among the most advanced digital societies globally, with exceptional e-government deployment – which, however, makes it vulnerable to various cyber threats. CHESS will directly follow the strategies and roadmaps of the European Cybersecurity Competence Pilots and build on the experience of CHESS partners involved in all four of these pilots, contributing to safe transition of the EU to full-scale digital society. The CHESS Hub will conduct a thorough needs analysis of the two regions and develop a joint cross-border R&I strategy for cybersecurity. The strategy development will be aided by implementation of pilot R&I projects that will reinforce the cross-regional collaboration, engage regional innovation ecosystems and build evidence for future projects. Gaps in skills and expertise identified in the regions will be removed by training and knowledge transfer. Finally, dedicated task forces will ensure sustainability of CHESS by integration with regional, national, and EU-level strategies and funding programmes. To exploit the project outputs, especially the pilot project results, CHESS will aid with market potential assessment and link researchers and innovators with entrepreneurship training and business consultancy services available in the regions. The strategizing, skills-building and pilot R&I will cover the totality of the cybersecurity field, with special attention to 6 Challenge Areas: Internet of Secure Things; Security Certification; Verification of Trustworthy Software; Blockchain; Post-Quantum Cryptography; and Human-centric Aspects of Cybersecurity.

Keywords: cybersecurity internet of secure things security certification verification of trustworthy software post quantum cryptography human centric aspects of cybersecurity
The Political Lives of Migrants: Perspectives from Africa (PolMig)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1499278.75
EU funding (EUR): 1499278.75
Participants: 1
Project status: SIGNED

Refugees and other migrants continue to arrive in new places all across the world. Their reception, long-term prospects and lives in their new homes remains one of the most pressing socio-political issues of our times. What about the migrant in all of this? How do they see their life, role and political agency? Migration research has thus far under-conceptualised and under-researched political migrant agency, especially from a Global South perspective and in interaction with states and non-state actors. PolMig aims to redress this gap and combine it with a commitment to tackle global inequalities in knowledge production. Focusing on Africa, PolMig considers how migrants define political agency, enabled or disabled by politicisation processes of belonging in postcolonial state contexts. Drawing on this research, PolMig advances an Afrocentric understanding of political migrant agency with global relevance. The research will consider the effects of different migrant trajectories (refugee or other migrant; transregional or intraregional; in country of destination, transit or return to origin) on the self-defined understanding of political agency, along intersectional principles of gender, class and race. PolMig uses pioneering research methods to do so including migrant agency diaries and theatre workshops. PolMig bridges the literature on migrant agency and migration states as well as contributing an Afrocentric perspective to the field. The Afrocentric perspective is ensured through a process of collaboration and exchange, centring the continent empirically and epistemologically. The innovative project will have significant scientific impact through addressing an interdisciplinary research gap and the commitment to highlighting and tackling knowledge inequalities. It also offers highly relevant policy contributions to an urgent societal question.

Keywords: agency,global south,knowledge production,political belonging
Advanced Fast-Ion Loss Measurements at the JT-60SA and ITER tokamaks (AFILM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Japan
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

One of the main challenges towards the commercialization of fusion energy is the appropriate confinement of alpha particles in burning plasmas as well as fast ions generated by auxiliary heating systems. This project contributes to that objective by aiming at the temporal and velocity-space characterization of fast-ion losses in the most advanced tokamak experiments (ITER and JT-60SA). i) Commissioning of a Fast-Ion Loss Detector (FILD) and its installation at the JT-60SA tokamak, including the synthesis of its scintillator plate, testing of its reciprocating system, optical calibration and assessment of its structural integrity. ii) Assessing the escaping fast ions generated by the 500keV N-NBI at JT-60SA. These unprecedented time-resolved velocity-space measurements under different regimes of operation will be validated using Hamiltonian full-orbit simulations. Moreover, advanced, first-principle hybrid kinetic-MHD modeling with the MEGA code will be used to reproduce the losses induced by Alfvénic instabilities. iii) Designing the ITER FILD and developing the technical solutions required to survive the harsh conditions at the ITER first wall. This includes thermo-mechanical assessment of the probe head, a synthetic diagnostic to estimate the signals, and the development of a scintillator plate with tolerable noise and degradation induced by neutrons and gamma radiation. This action is carried out at the Plasma Science and Fusion Technology group of the University of Seville in close collaboration with the ITER Organization, EUROfusion Consortium and JT-60SA teams. It includes two two-month secondments at QST (Japan) to install and exploit the JT-60SA FILD. Trough the execution of this project, the candidate will be trained to lead a research group of engineers and physicists implementing instrumentation relevant for the commercialization of fusion energy.

Keywords: fusion energy,tokamak,iter,jt 60sa,burning plasmas,alfv nic waves,plasma diagnostics,energetic particles,scintillator,fast ion loss detector,hybrid kinetic magnetohydrodynamic
New Foundations for Intensionality (GOOD INTENSIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499832.0
EU funding (EUR): 2499832.0
Participants: 1
Project status: SIGNED

Intensional notions such as those of property, content, proof, possibility and necessity are central to philosophy, logic, mathematics and linguistics. However, these notions are threatened by paradoxes reminiscent of those that plagued the foundations of mathematics at the beginning of the XX century. And while a consensus has emerged over which shape a foundation of mathematics should take, the intensional paradoxes are still awaiting solution. Indeed, the intensional paradoxes affect the major theories of content that in recent years have brought about what has been hailed as a hyperintensional revolution, with many applications in philosophy and linguistics. The GOOD INTENSIONS project aims to provide new philosophical, semantical and logical foundations for intensional notions, which will deliver a comprehensive and uniform solution to the intensional paradoxes. To achieve this, GOOD INTENSIONS will develop a fundamentally new approach to intensionality based on three ground-breaking ideas: a general, function-first approach to intensional talk, focused on its expressive role; a new, proof-theoretic approach to the semantics of intensional vocabulary; an original approach to the intensional paradoxes based on the use of intensional vocabulary in hypothetical contexts. The resulting new approach to intensionality will be used to develop new theories and logics of properties, content, proof and modality which are philosophically and linguistically motivated, paradox-free and logically strong. As a proof of concept for the new approach to intensionality, the new theories and logics will be applied to central philosophical questions, such as the question of whether the mind is a machine and the question of realism about properties. Based at the ILLC and advised by an international board of researchers, GOOD INTENSIONS will use an interdisciplinary methodology to revolutionize the study of intensionality.

Keywords: intensionality,expressive function,modality,property,proposition,provability