Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamics, Additive number theory and Algebraic geometry (DyAddAlg)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2223500.0
EU funding (EUR): 2223500.0
Participants: 1
Project status: SIGNED

The last two decade have witnessed a new spring for dynamical systems. The field - initiated by Poincare in the study of the N-body problem - has become essential in the understanding of seemingly far off fields such as combinatorics, number theory, and theoretical computer science. In particular, ideas from ergodic theory played an important role in the resolution of long standing open problems in combinatorics and number theory. A striking example is the role of dynamics on nilmanifolds in the proof of Hardy-Littlewood estimates for the number of solutions to systems of linear equations of finite complexity in the prime numbers. The interplay between ergodic theory, number theory and additive combinatorics and very recently also algebraic geometry has proved very fruitful; it is a fast growing area in mathematics attracting many young researchers. I propose to tackle a wide range of central open problems in the area, focusing on multidimensional averages in ergodic theory and additive combinatorics, the stability phenomena for polynomial rings in many variables, and randomness properties of arithmetic functions.

Keywords: multiple ergodic averages,combinatorial structure theorems,gowers norms,sarnak s conjecture,approximate cohomology,high rank varieties,strength of polynomials
Elucidating the effects of gut microbiota-derived metabolites in iPSC-derived co-cultures from ADHD patients (ELEGANCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 2
Project status: SIGNED

The pathophysiology of the most frequent neurodevelopmental disorder in the world, Attention Deficit Hyperactivity Disorder (ADHD), is influenced by the interaction of genetic and environmental risk factors. Studies have been indicating the association between ADHD and changes in the microbiota-gut-brain axis (MGBA), which may cause neuroinflammation, and subsequent microglial activation, secretion of cytokines and oxidative stress in the central nervous system. However, the precise mechanisms remain elusive and choosing a feasible individual-representative model to study pathomechanisms is challenging. ELEGANCE (“ELucidating the Effects of Gut microbiota-derived metAbolites iN iPSC-derived co-Cultures from ADHD patiEnts”) aims to investigate possible neuroprotective and neurotoxic properties of gut microbiota metabolites in induced pluripotent stem cell (iPSCs)-derived microglia and dopaminergic neurons from ADHD individuals in co-culture. Neuroinflammatory, oxidative stress and metabolic markers will be measured in different contexts (baseline and after treatment with potentially detrimental microbiota metabolites). Potential restoration effects by gut microbiota derived metabolites in compromised phenotypes will be also explored. These findings will elucidate interaction of microglia and dopaminergic neurons and gut microbiota derived metabolites in ADHD and thereby lead to promising novel drug targets. This fellowship will foster collaboration between world leading institutions and top-notch scientists, introducing me to the microbiome field, enhancing my expertise in transcriptomics, bioinformatics, networking and leadership. The project could significantly impact the knowledge about ADHD pathomechanisms and open doors for new treatment and dietary approaches targeting the MGBA.

Keywords: attention deficit hyperactivity disorder induced pluripotent stem cell disease modelling neuroinflammation oxidative stress microbiota gut brain axis gut microbiota microglia dopamine
Acquired adaptive immune cell dysfunction and restoration in chronic hepatitis B (EUCLIDEAN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

This proposal aims to investigate the development of dysfunctional adaptive immune cells during chronic hepatitis B virus (HBV) infection and to develop new strategies to reprogram them into functional cells with potent antiviral activity. Our hypothesis, based on extensive preliminary data, is that HBV induces a unique type of adaptive immune cell dysfunction that differs from that observed in other viral infections or cancer. To investigate this, we will use unique mouse models of HBV pathogenesis, several of which have been generated ad hoc for this proposal, and well-characterized patient cohorts to identify, dissect and target dysregulated pathways that cause adaptive immune cell dysfunction during chronic hepatitis B. State-of-the-art static and dynamic imaging will be employed to analyze the behavior of adaptive immune cells that ultimately differentiate into dysfunctional cells in the liver at unprecedented levels of spatial and temporal resolution. In parallel, high-dimensional flow cytometry and single cell sequencing in mouse models of HBV pathogenesis and in chronically infected patients will reveal the underlying proteogenomic landscape and heterogeneity that cause adaptive immune cell dysfunction. Finally, immunoregulatory mechanisms already identified in preliminary work or that will emerge from the above analyses will be targeted both in vitro and in vivo. By studying all the main players of HBV immunity together with state-of-the-art techniques and by interconnecting research with mouse models with analyses of human samples, we are in a unique position to make fundamental leaps in our understanding of adaptive immunity and viral pathogenesis. We are confident that the results emerging from this proposal will have the potential to guide the design of novel, rational strategies to direct the immune system to terminate chronic HBV infection and its associated costs and complications.

Keywords: hepatitis b,liver,cd8 t cells,b cells,chronic viral infection,multiphoton intravital imaging,t cell dysfunction
Control for Safety-Constrained Interactive Systems (CONCISE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1989960.0
EU funding (EUR): 1989960.0
Participants: 1
Project status: SIGNED

Interactive decision-making among multiple entities is critical in modern control systems, such as autonomous vehicle trajectory planning, resource coordination in smart power grids, and collaborative robotics. Safety constraints, including collision avoidance in autonomous vehicles and maintaining supply-demand balance in smart grids, are of paramount importance in these systems. However, ensuring safety remains a significant challenge due to its dependence on agents' coupled actions and stochasticities like unpredictable trajectories of road agents in autonomous driving and variable renewable energy outputs in smart grids. This research program proposes a framework for ensuring safety and performance for multiagent stochastic dynamic games. Dynamic game theory provides a powerful foundation for addressing interactive decision-making problems. Recent advances in artificial intelligence, particularly in solving complex multiagent problems, have led to the development of scalable algorithms for such decision-making challenges. However, existing algorithms lack provable performance guarantees when applied to real-world systems with constraints, leaving a critical gap in the field. The proposed research program addresses this gap by developing a theoretical framework guided by real-world challenges. To achieve this, it proposes to integrate recent breakthroughs in three fundamental fields of stochastic control, game theory and learning theory: safety assurance and control under partial information from stochastic control, characterizing tractable classes of games and ensuring equilibrium efficiency from game theory, and powerful function approximators with provable guarantees from learning theory. To bridge theory and practice, the program verifies the developed algorithms on real-world problems in transportation, power systems, and robotics, utilizing the PI's robotics testbed and ongoing collaborations with the energy sector. The anticipated outcomes inclu

Keywords: stochastic control,multiagent control,safety
TREEKIND® by BIOPHILICA. A unique, fully plant-sourced leather alternative, completely free of polyurethane. (Treekind)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: SIGNED

Biophilica proposes to advance R&D and scale Treekind®, a revolutionary certified 100% biobased, plastic-free leather alternative derived from green waste. Treekind® is currently available in small quantities for use cases including watch straps. In this project, we will conduct R&D for uses in footwear and upholstery, dramatically increasing our market competitiveness and ability to capture brand customers. This sustainable solution directly addresses the urgent environmental challenges caused by traditional leather and synthetic leather alternatives. Treekind® has met requirements for luxury watch straps. It has tunability, with a significantly reduced carbon footprint, and is PETA Vegan Approved Certified and verified home compostable (ISO 14855-1) distinguishing it from competitors. Building on successful watch strap applications, Biophilica will expand Treekind® into high-demand markets including footwear, furniture and automotive. This project needs substantial financial investment to overcome material research and scale-up hurdles. The current financial market dynamics regarding funding for startups are risk-averse, especially for novel materials that require time and funding to develop. To fully realise the potential of this innovation, we need the support of the EIC accelerator. By securing requisite funding, Biophilica can accelerate market entry, delivering a substantial positive environmental impact. Aligned with EU sustainability goals, legislation, and deadlines combined with a circular economy ethos, Biophilica spearheads sustainable material innovation. With EIC funding, we have the potential to address critical global issues at scale, while driving economic growth and job creation. This project positions Biophilica at the forefront of the transition to a more sustainable future.

Keywords: leather alternative,sustainable leather,plastic free
A cutting-edge digital dispensing system for next-gen electronics manufacturing (io600)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 3511250.0
EU funding (EUR): 2457875.0
Participants: 1
Project status: SIGNED

The semiconductor industry is aiming at producing smaller and more powerful chips. However, semiconductor packaging (back-end) technologies have reached their limits in terms of material deposition. Backend solutions for material deposition are 1) Subtractive technologies - etching and electroplating - highly polluting and, thus, unsustainable: and 2) Additive Manufacturing techniques that have reached their resolution limit considering the material fillers and/or viscosity, making it impossible to do smaller packaging and thus smaller chips. Our solution is the io600 system. It uses the CLAD (Continuous Laser-Assisted Deposition) technology to deliver high-volume deposition of any material on any kind of substrate, at a high throughput, highest resolution and without employing polluting materials. Io600 is a game changer in the semiconductor backend process with times higher viscosity than inkjet without any risk of clogging; 50% to 100% higher resolution compared to screen printers, jetters and needle dispensers; 35 times faster than dispensing systems; Smaller KOZ means higher packaging density (10% die-density improvement) and 40% lower CAPEX; Less clean room space (80% lower area); does not employ hazardous chemicals and saves 1 m3 of water per m2 in PCB manufacturing. IO600 customers are semiconductor packaging companies. They will benefit from the improved resolution, higher throughput, lower CAPEX and, because it is a not polluting process, the potential for reshoring the back-end process to the US and Europe. Io600 users of the chips built with io600 systems are electronic equipment manufacturers, which will design smaller, more powerful chips, key in electronics. Io600 aligns with EU strategic policies on Green Deal and sustainability, Digital transformation (better chip designs) and the EU Chips Act as allows reshoring of the backend process and bolsters Europe’s competitiveness and resilience in semiconductor technologies.

Keywords: advanced laser deposition technologies,semiconductor packaging,material deposition,additive manufacturing for semiconductors,chip packaging,laser assisted deposition
Green Borophene Sensing (GREBOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Air pollution is the biggest environmental health risk according to the EU and, it is responsible of several millions of premature deaths per year worldwide. In consequence, there is a growing demand for novel miniaturized, affordable, and reliable sensing devices able to detect pollutants at trace levels. The environmental monitoring market is estimated to grow at a CAGR of 4.1% to reach USD 17.10 billion by 2025. Within this market, the Air quality monitoring market size was valued at over 3.5B in 2018 and is expected to grow at a 7% CAGR. Noteworthy, through biogeochemical processes (i.e., acid rain) air pollutants released to the atmosphere can create a second pollution mechanism due to deposition in water surfaces, thereby increasing the potential threat to human health. Within this perspective, GREBOS lies in the development of a comprehensive sensing strategy employing innovative tailored functionalised borophene as a versatile nanomaterial for detecting trace levels of pollutants in both, water (SERS substrates) and air (chemoresistors) samples. This nanomaterial is at the forefront of research due to its superior and promising properties. In addition, borophene functionalisation with fluorine and phosphorous via low-energy ion irradiation will be studied for the first time, enabling novel studies about their changes in the electrical properties and surface chemistry. Besides, pollutants as nitrogen oxides and ammonia will be detected in both matrices below the threshold limit values established by the European Commission according to the Directive 2008/50/EC (air quality) and 98/83/EC (quality of the drinking water).

Keywords: borophene,gas sensors,sers substrates,ion irradiation,electronic properties
Pyrimidine de novo synthesis in tumor endothelium: an overlooked target? (EC-InterCom)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

It sounds simple: A cell cannot divide without nucleotides. Indeed, the disruption of pyrimidine de novo synthesis (PDNS) efficiently blocks proliferation of cancer cells. Yet still today, PDNS-directed anticancer treatment has not entered clinics due to the lack of efficacy. Why? Cancer cells gain pyrimidines via PDNS or from salvage pathways, and PDNS inhibition in cancer cells can likely be bypassed by pyrimidines produced in the tumor environment or gained from the systemic circulation. Can we target this microenvironmental interaction to improve treatment efficacy? A crucial component of tumor environment are blood vessels. Tumors stimulate their growth, angiogenesis, to gain oxygen and nutrients. Metabolism of endothelial cells (ECs), the inner vessel lining, is rewired in tumors, and tumor ECs upregulate PDNS. However, whether and how elevated PDNS in ECs supports tumorigenesis is unknown. I hypothesize that PDNS in ECs affects tumor environment either directly by providing pyrimidines to cancer cells or indirectly by stimulating angiogenesis, making systemic resources more accessible to cancer cells. The central goals of this project are (i) to identify the metabolic communication of ECs with other cell types in tumors, (ii) asses if endothelial PDNS promotes angiogenesis, and (iii) to seek novel metabolic targets in ECs, whose inhibition improves efficacy of PDNS inhibitors in vivo. To reach these goals, I will use an inducible mouse model to selectively disable PDNS in the endothelium. With this unique tool available at my host institute, I will integrate a state-of-the-art multi-omics and my expertise in metabolism to disentangle the network of metabolic communication using a powerful combination of spatially resolved single cell transcriptomics, metabolomics and functional genomics. My innovative approach will open a way for understanding the EC contribution to metabolic balance in tumors with a potential to identify new metabolic anti-cancer strategies.

Keywords: endothelial cells metabolism cancer multi omics nucleotides
SelF-powerIng electroNics – the Key to Sustainable future (SFINKS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2497319.0
EU funding (EUR): 2497319.0
Participants: 1
Project status: SIGNED

Scientific and technological achievements are often accompanied with pollution of the planet. Even electronics, believed clean, produces waste counting in trillions of batteries. We propose a solution that consists in battery-less self-supplying and thus helping to keep our planet green. Surprisingly, not only seas are exhibiting tides, the atmospheric pressure (P) and temperature (T) also do something similar. SFINKS will try to spark a new era of battery-less electronics via exploitation of the natural P/T “tides” to produce electricity in innovative micro-generators. The MAGIC of the P/T “tides” resides in that they are always-delivering and omnipresent. Such generators will thus produce energy continuously, everywhere, regardless their location, installation or orientation. This sounds like a dream, but… 5 years after I got this idea my PhD students found a wonderful confirmation that the dream may become true. Early 17th century C.Drebbel constructed an Eltham Perpetuum clock based on the principle of P/T “tides”. One of its followers, the Beverly clock, is still running despite never having been wounded since 1864. However, for all these 400 years the invention has remained relatively bulky and stagnated at mechanical energy stage. In SFINKS we will firstly miniaturize it towards monolithic Silicon technology and develop innovative co-integrated conversion to electrical energy. Our target will be the first always-delivering generator using an omnipresent energy source, the first free of any installation constraints, and also the first micro-scale generator using P/T “tides” to produce electricity! It will unblock further expansion of Internet of Things removing its bottle-neck i.e. batteries. Thanks to their quasi-perpetual lifetime, the SFINKS harvesters are also well suited to work on Mars, Venus or on board of satellites, where the P or T variations are very present. Our dream is to send a few SFINKS powered sensors with a space exploration mission on Mars.

Keywords: energy harvesting,internet of things,alternative energy sources,space exploration,solar planet missions,mars colonization,universal energy source,pressure temperature tides,self supplying,zero power electronics,battery less electronics