Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Circuit mechanics of emotions in the limbic system (EMOTIONCIRCUITS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Austria
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2018-06-30
Duration (months): 66.0
Total project cost (EUR): 1499922.0
EU funding (EUR): 1499922.0
Participants: 1
Project status: CLOSED

Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly interconnected neuronal populations. Resolving how emotions are processed in this network at the level of single neural circuits remains a major challenge. As entry point into the complexity of emotion circuitry, we propose to study, in exemplary fashion, how fear, as the most basic paradigm for emotions, is processed in key limbic hubs. Genetic manipulation of brain circuitry with electrophysiological methods and Pavlovian conditioning in mice, are powerful tools to explore which and how individual circuits in these hubs control emotional states, and, in turn, how genes and psychoactive drugs modulate circuit activity, emotional states and behavior. We envision this ERC funded research to uncover general principles of the network organization of both emotions and behaviors. It is our hope that we contribute useful tools and methodological framework for investigating other brain functions in a similar manner.

Keywords: circuit neuroscience mouse circuit genetics behavioral neuroscience
Reverse engineering of vascular patterning through mosaic in vivo analysis of endothelial cell shape regulation (RESHAPE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Belgium
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-10-01
End date: 2017-09-30
Duration (months): 60.0
Total project cost (EUR): 1373503.0
EU funding (EUR): 1373503.0
Participants: 1
Project status: CLOSED

Current angiogenesis research using genetic loss-of function approaches in mouse and zebrafish models provides for a growing number of genes implicated in blood vessel formation. Mechanistic insight often remains unsatisfactory as phenotypes fall into common categories. Our recent cell competition models combined with computational analysis have transformed the way we can study mechanisms in vascular patterning. I propose to systematically exploit mosaic analysis in vivo to deconstruct vascular pattern formation in development and disease. Single differentially labelled cells in mouse and zebrafish will be analysed to establish the first catalogue of endothelial cell shapes in reference to the position and developmental phase of the plexus. Dynamic imaging will describe functional shape transitions. Advanced computational analysis of 3D-segmented cell shapes using an optimized set of shape descriptors will be performed to find natural clusters via an unsupervised expectation maximization algorithm. Cross-correlation of shape clusters with gene expression, signalling, oxygen, polarity and cytoskeleton markers will be used to understand how cell shape relates to signalling and local environment. Pharmacological and clonal genetic gain and loss-of-function will be used to analyse dynamic regulation of cell shape leading to altered vascular patterning. Mosaic analysis in retinopathy and tumour models will enable unprecedented resolution to study vascular malformation. Sequential time-lapse imaging in combination with clinical imaging modalities will be used to bridge the gap between experimental and clinical tumour vasculature imaging, enabling us to ask how local environmental changes in the tumour affect blood vessel patterning. Successful completion of this work will establish the cellular and molecular principles governing vessel remodelling and provide a new conceptual framework and methodology for the analysis of pathological vascular patterning.

Keywords: angiogenesis,computational image analysis,in vivo imaging,mouse,zebrafish,tumour models,cell dynamics,retina,glioblastoma,clonal analysis,vascular remodelling
Estimating the effective reproductive rate of M. tuberculosis from changes in molecular clustering rates, to measure the impact of public health interventions on TB transmission (INTERRUPTB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Belgium,United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1490986.0
EU funding (EUR): 1490986.0
Participants: 2
Project status: CLOSED

Excessive delays in treatment onset limit current tuberculosis (TB) control programs, presenting a major obstacle to the control of the TB epidemic. Increasing case detection, both quantitatively and temporally, is considered a priority, benefiting the patient (reduced morbidity and mortality) and the society (shortened period of infectiousness). These improvements in patient care have a common goal: to reduce transmission and eventually contain the spread of TB within the population. However, assessing reduced transmission of TB proofs to be difficult, as to date molecular tools have not been integrated in mathematical models or in field trials of public health interventions. Therefore, I aim to develop a model that incorporates bacterial genotyping to follow TB transmission within the human host population, hypothesizing that an effective Enhanced-Case-Finding (ECF) method can interrupt TB transmission. Integration of routine epidemiological and genotyping data with bioinformatics and mathematical modelling provides a novel and powerful approach to understand the key determinants of the TB epidemic, such as the Effective Reproductive Number, and predict the dynamics of TB transmission. I have the unique opportunity to position the present proposal as an added-value study that builds on 3-year Cluster Randomized Trial of ECF that I designed, which is about to be launched in The Gambia in 2012. By applying molecular genotyping methods to bacterial isolates collected from both the ECF intervention- and control arm, I will develop a method to measure and model the impact of ECF on the transmission of TB. This will be the first study of its kind in integrating molecular genotyping data in a TB transmission model as applied to a population level interventional study. The identification of significant transmission parameters will be important both for basic TB research and also for health experts that design and evaluate Public Health TB interventions in the future.

Keywords: pathogen genomics,mathematical model
Investing in Education in Europe: Attitudes, Politics and Policies (INVEDUC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Institutions, values, beliefs and behaviour
Countries involved: Germany
Call:  (ERC-2012-StG_20111124, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 1479768.0
EU funding (EUR): 1479768.0
Participants: 1
Project status: CLOSED

Comparative welfare state research has neglected the study of education for a long time. In particular, very little is known about citizens’ attitudes on education policies and how these attitudes are reflected in processes of policy reform. The core of the proposed project is to conduct an original survey in eight European countries to provide, for the first time, internationally comparative data on individual attitudes and policy preferences on education. Individual attitudes are conceptualized to vary along three dimensions: the level of investment in education relative to other social policies, the promotion of different kinds of education (academic versus vocational education) and the distribution of competencies across levels of governments (governance). Particular attention will be paid to policy feedback effects, i.e. how macro-level institutional contexts (welfare states) shape the dynamics of preference formation on the micro level. Thus, the ultimate goal is to be able to understand cross-national variation in policy attitudes. The second phase of the project will analyze the linkages between attitudes and policy-making, using the insights from the survey. In the form of case studies of recent education reforms, we will ascertain whether policy-makers cater to public opinion in general, particular electoral constituencies or organized interests. The project breaks new ground by expanding research on welfare state attitudes to the field of education policy and improving our general understanding of the linkages between citizens’ preferences and policy-making.

Keywords: education policy,welfare state attitudes,survey,policy reform,public opinion,policy-making
Novel Identification Technology for High-value Plastics Waste Stream (POLYMARK)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Belgium,Germany,United Kingdom,Belgium,United Kingdom,Netherlands,Germany
Call:  (FP7-SME-2012, 2012)
Start date: 2014-01-01
End date: 2017-03-31
Duration (months): 39.0
Total project cost (EUR): 2240172.71
EU funding (EUR): 1478000.0
Participants: 11
Project status: CLOSED

The POLYMARK consortium represent the SME communities of Polymer Recyclers. The EU polymer recycling sector forms a vital part of the polymer sector and has an estimated annual turnover of €2,500 million generated by over 1,000 SMEs. However, our members have a major problem. Within the EU legislation exists (EC/282/2008) that states that plastic containers that have been used in a non-food application cannot, subsequently, be recycled and used in an application where it will come into contact with food. This is not true for other major world markets (including the US) putting Europe at a significant disadvantage and therefore a solution is urgently required. Additionally, the food packaging industry is under pressure to use more recycled content but has difficulty accessing sufficient volumes of food contact approved recyclate. In our industry recycling employs a combination of techniques that have been used for particular applications with varying degrees of success. However, they are all inefficient and expensive because there are no easy, reliable, rapid, low cost methods of distinguishing one plastic from another. Therefore an opportunity exists to capture this, to date, untapped market by undertaking the project we propose. Our solution is different. Our idea is to develop a food container marking and identification system that will allow reliable separation of food contact approved from non food contact approved post consumer plastic waste. The novelty is that the plastic itself is coded for easy identification. The technology will also be applicable to other plastic identification challenges. As well as benefiting the recycling community and the food packaging industry, it will also have a positive environmental impact.

Keywords: spectrometry,marker substances
Study on the need for food and health research infrastructures in Europe (EURO DISH)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Coordination and support actions
Countries involved: Netherlands,United Kingdom,Belgium,Denmark,France,France,France,Netherlands,Italy,Sweden
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-09-01
End date: 2015-08-31
Duration (months): 36.0
Total project cost (EUR): 2502146.57
EU funding (EUR): 1997946.0
Participants: 16
Project status: CLOSED

Europe is facing major challenges in promoting health and reducing the disease burden of age- and diet-related NCDs by means of lifestyle, food and nutrition. Research collaboration, innovation, and capacity building are essential to efficiently benefit from the – mainly public – research resources. To realise this, EU-wide Research Infrastructures (RIs) are essential. The aim of EURO-DISH is to provide advanced and feasible recommendations on the needs for RIs to ESFRI and other stakeholders. EURO-DISH will focus on needs for integration of existing and the development of new food and health RIs that are relevant for innovations in mechanistic research and public health nutrition strategies across Europe. Building upon available projects and mappings, we will systematically map existing RIs and needs for integration of existing and new RIs, and supporting governance structures throughout Europe. Food and health research comprises multiple disciplines and a broad research area. To assure a balanced attention for the area as a whole, the mapping will be organised around the ‘DISH’ model: ‘Determinants, Intake, Status, and Health’, which represents four key building blocks of the research area as well as different stages of RI development. To go beyond existing mappings, we will synthesize the results by integrating the needs for hard & soft RIs as well as governance; moreover as this may identify newly emerging gaps and needs, it will define larger entities of required RIs. We will develop a conceptual design and roadmap for implementing the most important RIs. It will include links with basic and human science infrastructures, as well as integration and collaboration with industry, third countries and feasibility. Two case studies on RIs, identified as highly relevant by the JPI HDHL for 2012-2015, will enrich the project by designing and testing of pilot RIs that feed the overall conceptual design and roadmap, which will be aligned with on-going activities.

Keywords: research infra structure-food and health-design roadmap
The development and evaluation of Multipurpose crops as new biorefining feedstocks for the production of industrial BioProducts and biomass (MULTIBIOPRO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Germany,United Kingdom,Sweden,Switzerland,Belgium,Germany,Spain,Germany,United Kingdom,Belgium
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 7345376.21
EU funding (EUR): 5770922.0
Participants: 11
Project status: CLOSED

The overall strategic objective of MultiBioPro is to exploit natural resources from genetic varieties of two industry-utilized plant species, poplar and the tobacco tree Nicotiana glauca, for direct applicability to novel industrial end products. The consortium will explore already existing poplar and N. glauca genotypes in parallel with innovative state-of-the-art translational research from the model organism Arabidopsis to genetically engineer metabolic pathways to advance qualities of wood fibers, and long-chain fatty acids. The modulation of fiber and long-chain fatty acid quality in both poplar and N. glauca will be examined through a multidisciplinary analytical platform that will optimize for key industrial values. An extensive cross-talk between the analytical platforms, biorefining and field trials will provide the basis for industrial determination of N. glauca and poplar varieties as new multi-purpose feedstocks. Importantly, residual biomass, e.g. suberin in poplar bark, that normally is considered waste products will also be analysed for its potential to yield long-chain fatty acids with important characteristics for new bio-materials and for biorefinery purposes. Both poplar and N. glauca may readily be grown in areas that are sub-optimal for food crop-species, and field-trials within the MultiBioPro project will further evaluate the environmental sustainability of the obtained poplar and N. glauca genotypes. Attributes that are advancing biorefinery and bio-material properties will be further exploited for marketing, demonstrating the industry-driven nature of the MultiBioPro consortium. Dissemination and training events will constitute an integral part of the project, and will include training modules in using different analytical platforms, industry-lead product-developing courses, management training and communication through the development of corporate and scientific dissemination toolkits.

Keywords: poplar,tobacco tree,biorefinery,non-edible oils,fiber quality,biomaterials,utilization of waste material,industry-driven,environmental sustainability,dissemination and training
Priority environmental contaminants in seafood: safety assessment, impact and public perception (ECSAFESEAFOOD)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Portugal,Spain,Slovenia,Belgium,Norway,Spain,Denmark,Spain,Netherlands,Spain,Italy,Ireland,France,France,Netherlands,Denmark
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 5085238.82
EU funding (EUR): 3999874.0
Participants: 19
Project status: CLOSED

Seafood has been recognized as a high quality, healthy and safe food item. Yet, some seafood can accumulate environmental contaminants with potential impact on human health. Limited information is available for those without maximum limits set by authorities for seafood, like priority contaminants, biotoxins from harmful algal blooms and marine litter. In order to increase seafood safety to consumers and reduce human health risks, ECsafeSEAFOOD aims to assess safety issues mainly related to non-regulated priority contaminants and evaluate their impact on public health. ECsafeSEAFOOD addresses these objectives with eight work packages (WPs) targeting priority environmental contaminants, including biotoxins from harmful algal blooms and marine litter. WP1 will elaborate a database with relevant information required for risk assessment gathered from literature and national monitoring programmes. WP2 will monitor contaminants in seafood using an ambitious sampling strategy following the recommendations of the Marine Strategy Framework Directive (Descriptor 9) and assess the effect of seafood processing/cooking on contaminants. In WP3, risk assessment (with data from WP1-2) and mitigation strategies will be implemented to reduce the impact of risky contaminants on human health. WP4 will develop fast screening/detection methods for relevant contaminants tailored to suit stakeholders needs to promote consumers’ confidence in seafood. WP5 will carry out the toxicological characterization of contaminated seafood in realistic conditions and will use alternative toxicological methods to provide tools for the risk assessment (WP3). WP6 will assess the links between the level of contaminants in the environment and that in seafood through controlled trials and case-study species, taking into account the effect of climate changes. WP7 details a strategy for education, training with clear and practical dissemination of results. WP8 will ensure efficient project management.

Keywords: seafood,priority environmental contaminants,database,monitoring,risk assessment,mitigation/dissemination,fast screening/detection tools,transfer between environment and seafood,climate changes
Bright Farm by Precision Livestock Farming (EU-PLF)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Belgium,Sweden,United Kingdom,France,Italy,Israel,Ireland,United Kingdom,Netherlands,Belgium,Germany,Netherlands,United Kingdom,Belgium,Spain,Faroe Islands
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 8013217.6
EU funding (EUR): 5895357.0
Participants: 20
Project status: CLOSED

The objective of the EU-PLF project is to deliver a validated Blueprint for an animal and farm-centric approach to innovative livestock farming in Europe proven through extensive field studies. This blueprint represents a manual for farmers and their surrounding industry including high tech SME’s and other stakeholders. It is a reference tool offering pragmatic guidance on how Precision Livestock Farming (PLF) systems can be applied to farm level in order to create value for the farmer and other stakeholders. EU-PLF is based on the PLF concept that represents the continuously automated measurements directly on the animal or in its environment. Beyond the use of the PLF data (body movements or sounds, etc.) for monitoring and management, the data can be translated into key indicators on animal welfare, animal health, productivity and environmental impact. Highly experienced European teams from different disciplines with a proven track record in animal and PLF-related fields - animal scientists, veterinarians, ethologists, bio-engineers, engineers, social scientists and economists, leading industrial market players in the livestock industry and high tech SME’s – have joined to deliver a useful PLF Blueprint. Most of the academic partners are leading previous research projects funded by the EU in animal and PLF related fields. To ensure that the Blueprint assists the European livestock industry beyond the duration of the project, 50 SME’s or potential starters will be identified all over Europe to play a key role in the EU-PLF project. With a competition for SME’s and starters, the best ideas get funding to design a PLF-prototype with their high tech innovative solutions. In collaboration with a leading industrial PLF-partner, they use the Blueprint to bring their prototype to farm level. This allows developing business models and linking high tech SME’s to European industry players to create new PLF-products with global impact.

Keywords: precision livestock farming,animal key indicators,socio-economic measures,animal health and welfare,environmental load,animal productivity,value creation,high-tech smes,blueprint