Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative water current picoturbines for the economic and sustainable exploitation of the renewable energy from rivers and estuaries (EcoCurrent)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In 2016, over 1.2 billion people in the world (16% of the global population) still did not have access to electricity. As the majority of these people are located in remote and rural areas of the world, where conventional power grid extensions are not possible, off-grid energy solutions are required for providing electricity to these areas. Even though such solutions exist today, the options available are painfully limited and costly, whether it be the polluting diesel generators or the solar panels, intermittent energy source requiring complex parks of batteries for energy storage. Tackling this issue, our company, EDIE EcoCinetic, a technology-driven micro-enterprise, has invented EcoCurrent, a water current picoturbine which harnesses the energy from the available flow of canals, rivers and tidal currents to generate electricity. Specifically design for water, our technology is compact, robust, efficient, easy to install and operate; and will provide to rural and remote population a solution adapted to their hydrokinetic resources to address their needs for a continuous, reliable and affordable electricity. With EcoCurrent, our universal and affordable technology which will improve living conditions of millions of people in Europe and abroad, we aim to become one of the international leaders in the emerging market of hydrokinetic picoturbines. The strong penetration, supported by EcoCurrent competitive price for unrivalled features, will lead to +€20.15 million of accumulated revenue within the 2020-2024 period, and will generate 28-30 internal job opportunities with the first 5 years of exploitation.

Keywords: picoturbine,hydrokinetic turbine,hydroelectricity,river,water current,renewable energy,efficiency,ruggedness,eco friendly,ichtyophile,energy autonomy,off grid
Mask Based Lithography for Fast, Large Scale Pattern Generation with Nanometer Resolution (Nanolace)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Norway,Greece,Sweden,Norway,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 3642284.24
EU funding (EUR): 3356511.75
Participants: 7
Project status: SIGNED

Lithography refers to the transfer of a pattern onto a substrate. Lithography techniques are used in the production of a huge range of devices and materials ranging from microelectronics and MEMS devices to optical metamaterials and smart surfaces for medical and other applications. The ultimate goal and limit of lithography is to obtain fast and large scale patterning which enables the controlled positioning of individual molecules or atoms. This requires fast, large scale single nm resolution patterning. At the moment no techniques are available that can do that. Fast positioning of individual molecules or atoms over large areas can path the way for the creation and industrial application of whole new classes of materials and devices including room temperature quantum electronic devices, electronic metamaterials as well as nano filtration membranes and can push the performance of todays microelectronics. The highest resolution (~20 nm), fast, large scale lithography technique today is photolithography where a photon beam is projected through a mask, so that the pattern from the mask is replicated by direct imaging on a substrate coated with resist. Next generation Extreme Ultra Violet (EUV) lithography uses 92 eV photons and is targeted to deliver 8 nm resolution. The EUV ultimate limit, determined by the secondary electron generation blur, is estimated to be around 6 nm, which does not enable single nm resolution patterning. Further reductions in the photolithography resolution of the patterning would increase the photon energy, exacerbating the secondary blur. In Nanolace, a radical breakthrough to reach nm resolution lithography will be demonstrated: single nm resolution patterns will be generated with solid state and optical masks, proposed by partners in the consortium using metastable and Bose Einstein condensated atoms. Nanolace will be the first demonstration of lithography with a Bose Einstein condensate.

Keywords: molecular beams,matter wave lithography,resist,matter wave optics,lithography
Open Researchers 2021 (OPENRESEARCHERS2021)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Spain,Spain,Spain,Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-04-01
End date: 2022-01-31
Duration (months): 10.0
Total project cost (EUR): 292383.5
EU funding (EUR): 154102.82
Participants: 13
Project status: CLOSED

Open Researchers 2021 is the 10th Andalusian experience in the European Researchers' Night. The project is designed to increase the awareness of research as a solution to the numerous challenges faced by citizens all around the world, as well as pursuing the EU Green Deal to meeting the SDGs. "A green science with and for citizenship: Facing the challenge of creating a neutral climate future in Europe" is the main idea of the project. It has been conceived at a time where it becomes clearer that we must join efforts to find sustainable, equal and innovative solutions to achieve the Green Deal goals. Understanding that science is present in our daily lives, it should be accompanied by a scientific culture that will prepare citizens to a reality full of challenges. It is essential to promote youth interest in Science by opening it to the general public through researchers in an accessible way. Fundacion Descubre will coordinate this project, based on its experience through the last decade working with relevant projects and in its consortium experience in the previous NIGHT projects. The consortium is composed of 9 Andalusian universities, the Spanish National Research Council (CSIC), Andalusian Foundation Progress and Health, and the Royal Botanical Garden of Cordoba. The project's major strength is the numerous activities taking place on streets, theatres, and historical buildings of the 8 Andalusian cities, with a high mobilization of researchers and collaborating institutions. To reinforce this, partners will consolidate a strong online programme of activities and a TV show. The European dimension will be underlined by the active involvement of researchers with European funds and Marie Sklodowska-Curie fellows in the EU Corners and in the pre-events. Gender balance will be guaranteed in researchers as well as the RRI for designing inclusive and sustainable R&I. The project includes a European collaboration to design a set of activities linked to the Green Deal.

Keywords: societal challenges,researchers,green deal,scientific vocations,understandable science,equal opportunities,inclusion,responsible research and innovation rri,scientific culture
The origins of dendritic computation within mammalian neural circuits (DENDRITECIRCUITS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-07-01
End date: 2022-12-31
Duration (months): 78.0
Total project cost (EUR): 2495563.0
EU funding (EUR): 2495563.0
Participants: 1
Project status: SIGNED

This proposal aims to address a simple question: what is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also if we are to build accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. In this proposal, we will build on recent work demonstrating that dendrites are highly electrically excitable to test the possibility that single dendritic branches may act as individual computational units during behaviour, challenging the classical view that the neuron is the fundamental unit of computation. We will address this question using a combination of electrophysiolgical, anatomical, imaging, molecular, and modeling approaches to probe dendritic integration in pyramidal cells and Purkinje cells in mouse cortex and cerebellum. We will first define the computational rules for integration of synaptic input in single and multiple dendrites by examining the somatic and dendritic responses to different spatiotemporal patterns of excitatory and inhibitory inputs in brain slices. Next, we will determine how these rules are engaged by patterns of sensory stimulation in vivo, by using various strategies to map the spatiotemporal patterns of synaptic inputs onto single dendrites. To understand how physiological patterns of activity in the circuit engage these dendritic computations, we will use anatomical approaches to map the wiring diagram of synaptic inputs to individual dendrites. Finally, we will perturb the dendritic computational rules by manipulating dendritic function using molecular and optogenetic tools, in order to provide causal links between specific dendritic computations and sensory processing relevant to behaviour. These experiments will provide us with deeper insights into how single neurons act as computing devices.

Keywords: dendrites,neural circuits,neural computation,optogenetics,connectomics,dendritic spike,synaptic plasticity
ENVironmental Research Infrastructures building Fair services Accessible for society, Innovation and Research (ENVRI-FAIR)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Spain,Spain,Spain,Ireland,Italy,Italy,Italy,Germany,Belgium,Norway,Norway,Finland,Sweden,Norway,Norway,Norway,Serbia,Greece,Romania,Slovenia,Sweden,Belgium,France,France,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: Connecting ESFRI infrastructures through Cluster projects (H2020-INFRAEOSC-2018-2, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 18997878.75
EU funding (EUR): 18997878.75
Participants: 56
Project status: SIGNED

ENVRI-FAIR is the connection of the ESFRI Cluster of Environmental Research Infrastructures (ENVRI) to the European Open Science Cloud (EOSC). Participating research infrastructures (RI) of the environmental domain cover the subdomains Atmosphere, Marine, Solid Earth and Biodiversity / Ecosystems and thus the Earth system in its full complexity. The overarching goal is that at the end of the proposed project, all participating RIs have built a set of FAIR data services which enhances the efficiency and productivity of researchers, supports innovation, enables data- and knowledge-based decisions and connects the ENVRI Cluster to the EOSC. This goal is reached by: (1) well defined community policies and standards on all steps of the data life cycle, aligned with the wider European policies, as well as with international developments; (2) each participating RI will have sustainable, transparent and auditable data services, for each step of data life cycle, compliant to the FAIR principles. (3) the focus of the proposed work is put on the implementation of prototypes for testing pre-production services at each RI; the catalogue of prepared services is defined for each RI independently, depending on the maturity of the involved RIs; (4) the complete set of thematic data services and tools provided by the ENVRI cluster is exposed under the EOSC catalogue of services.

Keywords: data services,environmental science,research infrastructures,fair
Protection from malaria in the Fulani ethnic group of West Africa involves reduced levels of A-to-I RNA editing by ADAR1 (QuinADAR1)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-06-01
End date: 2021-11-27
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: CLOSED

I will investigate what mediates an effective human immune response to infection with Plasmodium falciparum malaria. I will approach this through studying the Fulani ethnic group of West Africa, who are relatively resistant to malaria infection. The basis of the Fulani protection from malaria has never been established. However, we have performed a pilot study which suggests that reduced levels of adenosine-to-inosine (A-to-I) editing of RNA by ADAR1 following P. falciparum infection can drive a more effective innate immune response in the Fulani. We have an established collaboration with the Malaria Research and Training Centre at University of Sciences Technique and Technology in Mali, who have strong ties to the Fulani community. At Stockholm University, I have had the opportunity to develop a strong background in immunology research techniques, specifically utilizing in vitro models of malaria infection in human monocytes, in the research group of Eva Sverremark-Ekström. As the role of RNA modifications is an emerging field, I plan to move to CEITEC, Czech Republic, to work with Mary O’Connell, who has pioneered the role of A-to-I RNA modification in the innate immune response to RNA. Specifically, we will test the hypothesis that reduced rates of A-to-I editing of RNA in the Fulani following infection enables them to mount a more effective innate immune response to P. falciparum malaria, and contributes to their relative protection from the disease. Further, targeting of ADAR1 and/or reduction in levels of A-to-I RNA levels may present a novel strategy to boost effective immune response to malaria.

Keywords: malaria,fulani,adar1,a to i editing of rna,innate immune response,plasmodium
Development of a novel and ecologic mortar based on nanoparticles of lime and organic additives for the repair of Built Heritage and new construction (NANOMORT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-12-21
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Cultural Heritage represents nowadays a significant industry in Europe which produces more than 30 billion € in revenues every year. The repair of historic lime mortars is currently being carried out by the application of fresh lime mortars following traditional recipes due to their high compatibility, permeability and flexibility. However, they present some important limitations such as long setting and hardening times, weak mechanical properties and low internal cohesion, which compromise their effectiveness and durability. There is an important need in the EU and worldwide to develop innovative ways to produce mortars for new construction and repair of historic mortars with improved properties, compatibility and sustainability as compared to Portland cement. This research aims to provide the first comprehensive research on the development of the first high ecologic mortar made of nanoparticles of lime (nanolime) and natural organic additives. This research aims to: i) develop a medium-scale reactor for the synthesis of nanolime; ii) characterize nanolime in presence and absence of additives; iii) define optimal nanolime mortar mix. The novel use of nanolime for mortar production will potentially keep the same permeability, compatibility and flexibility, and will reduce the limitations of lime mortars reducing the setting and hardening time. Moreover, the addition of additives will improve their durability and strength. The synergistic interaction formed by the host group, world expert in nanolime, mineralogy and heritage conservation, and the applicant, an expert in nanolime and production of mortars, guarantees the maximization of two ways transfer of knowledge, training and networking possibilities. The outcomes of NANOMORT will have a high impact on the construction and repair of the European Built Heritage; and to the collective interests of mankind for its high sustainable factor, which is one of the main goals of the European Commission on Horizon 2020.

Keywords: mortar,ecologic,construction,building,repair,heritage,novel,nanolime,nanoparticles,lime
Make it, don’t break it: a reconstitution screen for Casparian strip formation in the root endodermis (Wall-E)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

In plants, the root endodermis functions as a barrier, allowing the selective uptake of nutrients and water. The barrier is formed by cell wall impregnations called Casparian strips (CS), produced by differentiating endodermal cells. In the last decade, pioneering work on the endodermis has identified numerous players involved in CS formation, including transmembrane proteins, peroxidases, dirigent-like proteins, lignin polymerising enzymes, laccases and super-oxide dismutases. However, the forward and reverse genetic approaches used to uncover these proteins are slowly coming to a standstill due to their limitations when faced with gene redundancy or genes with a broader range of activities, causing pleiotropy or lethality. I now propose to use CS formation as a model in order to pioneer a combinatorial, gain-of-function screen, aiming to define a minimally sufficient gene set for the assembly of a CS. I will attempt to reconstitute a CS in the endodermis of the myb36 mutant – a master regulator of endodermal differentiation - by activation screening for genes within the MYB36-dependent gene set. Firstly, I will introduce a “core machinery” for CS formation by expressing important known players and assessing CS formation and stability (WP1). Secondly, I will test the most recently developed second generation CRISPR activator systems for their efficiency in activating genes of interest in the endodermis (WP2). Thirdly, using the CRISPR activator technology, I will screen for novel genes that will improve the formation, stability and functionality of the CS (WP3). Identifying new genes involved in CS formation through a combinatorial, gain-of-function approach represents a novel way to genetically elucidate molecular mechanisms and could become a model for other cellular and developmental processes in Arabidopsis or other organisms.

Keywords: crispr activator systems,gain of function reconstitution screen,endodermis,casparian strip formation
Comparative modelling of organoids in the age of single-cell transcriptomics (OrganoidAlign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-15
End date: 2023-07-11
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The OrganoidAlign action will develop a solid computational framework for comparative modelling of organoids in the age of single-cell transcriptomics. It will provide direct payoffs to both, tissue engineering and single-cell genomics fields. The overarching goal is to build a set of statistically rigorous and consistent probabilistic models for aligning a single-cell transcriptomic profile of an organoid against its in vivo tissue, for quantitatively evaluating its recapitulatory power. During the course of this action, a meticulous review will be conducted on the state-of-the-art single-cell data modelling and comparative analysis techniques prior to formulating the single-cell transcriptomic profile comparison problem in statistical learning theory. This will specifically focus on both cell clustering and cell trajectory inference methods. A new statistical framework will be implemented to accommodate a comprehensive comparison between a pair of in vitro and in vivo transcriptomic profiles. A rigorous scoring measure will be devised to quantify their alignment. Overall, the inference components under the proposed framework will facilitate the prediction of missing or outlying cellular attributes, transcriptional factors and signaling pathways in organoids compared to their in vivo tissues, informing directions of organoid protocol improvement. Overall, its outcomes will have potential contributions towards engineering more reliable in vitro tissue models, as well as reference profiling of organoids under the Human Cell Atlas project.

Keywords: single cell genomics,organoids,machine learning,missing factor prediction