Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Epigenetic Reprogramming, Inheritance and Memory: Dissect epigenetic transitions at fertilisation and early embryogenesis (EpiRIME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 1997500.0
EU funding (EUR): 1997500.0
Participants: 1
Project status: SIGNED

During gametogenesis, germ cells undergo profound chromatin reorganisation, condensation and transcriptional shutdown. Upon fertilization, gamete chromatin is epigenetically reprogrammed, generating a totipotent zygote that can give rise to all cell types of the adult organism. The maternal factors that reprogram gametes to totipotency are unknown. The current dogma suggests that the parental epigenetic information must be erased in order to establish totipotency. In contrast, we have recently discovered that maternal gametes transmit the epigenetic H3K27me3 histone modification to the next generation (Zenk et al., Science, 2017) adding to increasing evidence suggesting that gametes convey more than just DNA to the offspring. Nevertheless, the underlying mechanisms and the impact of epigenetic inheritance through the gametes are not yet fully resolved. Critically, the mechanisms and impact of (i) paternal gamete reprogramming, (ii) paternal epigenetic inheritance and (iii) de novo establishment of the zygotic epigenome remain essentially unknown. The objective of this proposal is to unravel the fundamental principles underlying these three major epigenetic transitions in vivo in Drosophila. We will achieve our objective via three aims: (i) We will investigate the mechanisms underlying the reprogramming of sperm chromatin at fertilization. Specifically, we will determine the nature and extent of the contributions of two proteins essential for sperm chromatin reprogramming (ii) We will examine the mechanism of histone H3K27me3 inheritance through the paternal germline (iii) We will genetically dissect the de novo establishment of constitutive heterochromatin in the newly formed zygote. Our investigations of these epigenetic transitions are expected to reveal novel insights into the first steps in the formation of life, and to ultimately advance reproductive and regenerative medicine.

Keywords: germline,epigenetic inheritance,epigenetic reprogramming,drosophila early embryo development,polycomb
Remotely quantifying vegetation productivity: exploiting sun-induced fluorescence-photosynthesis relationships through field and modelling methods (FLUOPHOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

During the past few years airborne/spaceborne detection and quantification of sun-induced chlorophyll fluorescence (SIF) emitted by terrestrial vegetation became possible at several narrow wavelengths. These improvements in Earth Observation technology offer huge possibilities to increase our knowledge on the basic functioning of the Earth’s vegetation, i.e. the photosynthetic process of plants resulting in atmospheric carbon uptake. However, still some efforts are required for establishing well-funded relationships between SIF and photosynthesis under different plant physiological states. Hence, in order to improve the quantification of photosynthesis through SIF, the main aim of this proposal (FLUOPHOT) is to further establish the link between the SIF characteristics and both the actual and potential photosynthesis of the plant. This will be achieved by coupling dedicated field/laboratory measurements and campaigns with modelling activities. As a result of the planned activities, significant progress is foreseen in the remote quantification of vegetation productivity. FLUOPHOT strives to unravel fundamental SIF-photosynthesis systems at the leaf and canopy scale. These findings are in direct support of ESA’s candidate Earth Explorer mission FLEX, and eventually will lead to unbiased global estimates of photosynthetic carbon uptake.

Keywords: sun induced chlorophyll fluorescence
The untapped potential of omega-3; from fish oil to healthy bowels (Lipid)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Europe's consumers are increasingly requesting products that are organically and sustainably produced. At the same time, Europe has been lacking incentives to develop and bring to markets new marine products, without increasing pressure on natural resources. The innovation in question; a natural, sustainably produced medicine based on marine oils, addresses these challenges. It is based on the discovery that omega-3 oils have proven to have laxative effects. It offers parents and pediatricians a pain-free alternative to other pharmaceutical products, in a market where no new products have been introduced for decades. The innovation also paves the way for the full utilization of marine products, demonstrating that by-products can be of high value for other industries, including the pharmaceutical sector. The aim of the applicant is to develop this innovation all the way towards a market-ready, licensed pharmaceutical product. The pharmaceutical industry is one of the largest industries in the world in regards to revenues. Over 100 million people worldwide, suffer from constipation. The active ingredient of the innovation product would be a new and a unique addition to this growing market. The applicant seeks support to be able to obtain a solid analysis of the market potential for the innovation. If successfully brought to markets, it will reach the milestone of being the first non-generic, registered drug, tested in clinical trials in humans that was discovered, developed and produced in one of Europe's most peripheral corners, Iceland.

Keywords: natural,sustainably produced medicine based on marine oils,designed specifically for the use on children
Micro-, Meso-, and Macro-Level Determinants of Educational Inequalities: An Interdisciplinary Approach (DetEdIn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 171792.6
EU funding (EUR): 171792.6
Participants: 2
Project status: CLOSED

Governments across the world recognize the right of the child to education on the basis of equal opportunity. Education shall allow children to develop their talents, abilities, and personality, and the principle of equal opportunity shall guarantee the eradication of any kind of discrimination. Accordingly, in a meritocratic system, educational outcomes should be directly related to individual merit. However, research shows that ascriptive (‘non-merit’) characteristics such as social origin also play a role in shaping educational outcomes. For instance, across OECD countries, no more than one out of five students from families with a low educational background attains a degree in tertiary education, as opposed to two thirds of students from families with at least one parent with tertiary education. These disparities are often considered as a measure of inequality of opportunity and therefore deserve attention from both scientists and policymakers. To date, despite an increasing body of knowledge on educational inequalities, only very little research exists on additive and interactive effects of micro-, meso-, and macro-level characteristics on educational inequalities. Against this background, the proposed research project shall use an interdisciplinary analytic framework to assess how micro-level psychological characteristics (e.g., self-efficacy and motivation), meso-level (family and school) characteristics, and macro-level characteristics (educational policies and wider societal contexts) affect social inequalities in education, and whether their distinct combinations shape inequalities. Data will be derived from standardized cross-national surveys (PISA, TIMSS) as well as from longitudinal cohort studies (e.g., BCS70, MCS, YDS). A variety of state-of-the-art research methods will be employed, including multilevel analysis and growth curve modeling, to generate scientific evidence and extend theory on major determinants of social disparities in education.

Keywords: education,inequality,multilevel,policies,human development in context
The Evolution of Bacterial Warfare (MicroWars)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2750137.0
EU funding (EUR): 2750137.0
Participants: 1
Project status: SIGNED

Many bacteria are extremely aggressive. They assemble poisoned molecular spears to stab neighbours, they release protein machines that punch holes in competitors and, moreover, some cells will commit suicide in order to launch their attack. While there is a large literature on the evolution of combat and competition in animals, this has focused on why animals are generally reluctant to fight. The evolution of extreme aggression in bacteria, therefore, challenges our current understanding of competition in biology. I will develop bacterial warfare as a model for competitive behaviour by asking three key questions that each build in complexity: 1) Why do weapons evolve? 2) What tactics do bacteria use during combat and why? 3) How does ecological complexity influence the value and use of weapons? My group will examine these questions theoretically and test our predictions using two model species, Escherichia coli and Pseudomonas aeruginosa, which possess very different levels of weaponry. The project has risk and challenges in that bacterial behaviours cannot simply be watched like animal behaviours. To meet these, we will employ a proven combination of individual-based modelling, game theory, competition experiments, experimental evolution, confocal microscopy, molecular genetics, genomics and germ-free mouse work. We will also co-develop new techniques. Freestyle microfluidics will position bacteria and weaponry for study; electron fluorescence cryomicroscopy will image, for the first time, bacterial battlegrounds at the molecular scale. By combining cutting-edge methods with clear evolutionary questions, I aim to provide a major new perspective on combat, and on bacteria. There is currently an intense interest in how bacteria establish in host-associated communities, including the mammalian microbiome. Understanding this will need a new focus on the evolution, and ecology, of bacterial warfare.

Keywords: mathematical modelling,social evolution,microbiota
FABER-Net: A unique network of labs dedicated to the diagnosis of allergies using the innovative FABER test (FABER-Net)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Allergies are the most common chronic disease: with >1B people affected globally, of which >150M in Europe, today allergies are a worldwide epidemic. Besides clinical symptoms such as rhinitis, asthma and atopic eczema, allergies cause distress in those affected, who live in fear of an asthma attack, anaphylactic shock, or death from an allergic reaction. In addition, allergies have high costs for businesses and society: in the EU, work absenteeism of allergic patients costs €55-151B/year, while families with one allergic child or adult spend an extra €3,900-8,100/year. A high-quality and reliable allergy diagnosis is essential to identify the best treatment option for allergic patients and improve their health, and also to reduce costs. Today there are >3000 molecules known to cause allergies, but current methods for diagnosis are not able to test a high number of allergens, at a reasonable price and in a short time; also, most of them are invasive and present some risks for the patients. On top of this, every year new allergens are discovered, but they can’t be included in diagnostic tests for technical and economic reasons. To overcome these limitations ADL has created the FABER test: a multiplex system for allergy diagnosis that can test 301 allergens at the time - the highest number currently available. This is a flexible system based on nanotechnology in which the number of allergens can be increased when new ones are available. ADL aims to expand in Europe and then worldwide the network of labs that provide FABER allergy diagnosis at the most local level and with ADL’s highest testing quality. Thanks to this network (FABER-Net), the FABER test will be available for many patients suffering from allergies, who will have a more informative diagnosis, which in turn will allow a more personalized and effective treatment. This will improve the patients’ health and reduce their absenteeism from work, thus cutting costs in healthcare and associated with work absence

Keywords: micro array,multiplex assay,molecular allergology
6i-DIRS: A growing attractive collaborative ecosystem for boosting impact driven research careers (6i-DIRS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-10-01
End date: 2025-02-28
Duration (months): 65.0
Total project cost (EUR): 3091680.0
EU funding (EUR): 1545840.0
Participants: 1
Project status: SIGNED

6i-DIRS will recruit 19 qualified ESRs for high quality doctoral training to · promote their social contributions; · generate interdisciplinary, international and intersectoral projects and dissertations; · support and broaden their career prospects. Grounded on a robust, dynamic and attractive ecosystem, 6i-DIRS fosters cooperation and co-creation among 7 PhD programmes and 19 externally evaluated excellence teams, that support them with research and training around · 5 interdisciplinary platforms on EU and global challenges: Ageing and Wellbeing; Cultural and Creative Industries, Cities and Regions; Gender; Social Justice and Inclusion; and Strengthening Participation; · 4 interdisciplinary areas aligned with the Basque Smart Specialisation Strategy on Health; Sustainable Development and Innovation in Energy, Industry 4.0 and Mobility. DEUSTO has prime conditions for frequent dialogue between economic, cultural and social actors. 46 established partners and 15 co-financing entities back 6i-DIRS, ensuring international and intersectoral mobility to broaden ESRs’ employability. Recruitment will be open, merit-based, impartial, equitable and international. It will avoid any form of discrimination, with international recommendations for transparent and ethical assessment at the core and in line with the European Charter and Code of Conduct and benefiting from H2020 Gearing-Roles project on institutional change. Successful candidates will sign an employment contract, and will have shared supervision and mentoring as detailed in the Doctoral Agreement and their individual training plan. Full internationalisation is essential in 6i-DIRS, COFUND will - consolidate the rate of international ESRs (34% of PhDs in 2017/18); - help with capacity building with Eastern institutions, sharing strengths and lessons learned; and - consolidate DEUSTO’s internal procedures to attract international talent and grow in scientific excellence, innovation, social engagement and impact.

Keywords: excellent research and training,international,interdisciplinary,intersectoral,social impact,innovation,inclusion,researcher career,transnational and cross sectoral mobility,open recruitment,best practices
Beyond CULtural TOURism: human-centred innovations for sustainable and circular cultural tourism (Be.CULTOUR)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Innovation actions
Countries involved: Italy,Spain,Italy,Germany,Italy,Cyprus,Moldova, Republic of,Serbia,Belgium,Romania,Sweden,Sweden,Netherlands
Call: Innovative approaches to urban and regional development through cultural tourism (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 4097203.75
EU funding (EUR): 3993328.75
Participants: 16
Project status: SIGNED

Cultural tourism entails opportunities but also risks. If not managed properly, cultural tourism can easily turn into a “value extractive” industry, generating negative environmental, social and cultural impacts on local communities and ecosystems. This project will develop specific strategies to promote an understanding of cultural tourism, which moves away from a “stop-and-go” consumer-oriented approach towards one that puts humans and circular economy models at its centre, paying attention to nature, communities and cultural diversity. “Place”, intended as the genius loci, the ancient spirit of the site and “people” as co-creators of its uniqueness, culture, art, tradition, folklore, productivity, spirituality, are the focus of Be.CULTOUR. Wide and diversified partnerships of stakeholders from 18 EU and non-EU regions of Northern-Central and Southern Europe, the Balkans, the Eastern neighbourhood and the Mediterranean, will be the driving force of the project. A community of 300 innovators (which includes regional authorities and municipalities, clusters and associations, museums and tourist boards, entrepreneurs, chambers of commerce, citizens, researchers, practitioners as well as project partners) in 6 pilot regions will co-create innovative place-based solutions for human-centred and circular cultural tourism. Collaborative “Heritage innovation networks” will be established in 6 European deprived remote, peripheral and deindustrialised areas and cultural landscapes identified as “pilot heritage sites”: committed to the project’s objectives, they have defined clear cultural tourism related challenges requiring innovation, which will serve as the basis for the collaboration with 12 additional “mirror ecosystems”.

Keywords: cultural tourism,europeanisation,cultural heritage,collaborative innovation,open innovation,human centred development,human centred design,financing instruments
Identifying subtype specific networks involved in sensory representation in mouse primary visual cortex (SUBNETVIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

To produce relevant behaviors, the brain integrates and processes sensory information. Neurons in the primary visual cortex extract sensory information by responding preferentially to certain visual features. This feature preference, or tuning, is thought to arise from structured connections established between cortical neurons. Accordingly, it was found that connected neurons in the cerebral cortex share similar tuning properties. Interestingly, the neurons populating the cerebral cortex correspond to numerous neuronal subpopulations, involved in different functions. However, the functional involvement of this large neuronal diversity in cortical computation has been so far studied for a few broad neuronal subpopulations, leaving the fine subpopulations mainly unexplored. Do these poorly studied neuronal subpopulations share similar tuning properties? Is the structured connectivity giving rise to tuning subpopulation specific? I will use a new technique referred as in situ transcriptomics to study the tuning properties and locomotor modulation of the diverse neuronal subpopulations in the mouse primary visual cortex. This technique provides high throughput identification of neuronal subpopulations on fixed tissue based on the transcriptomic signature of neurons. I will thus determine the identity of in vivo recorded neurons a posteriori and decipher the relationships between cell identity and responses to visual stimuli. Combining this approach with single cell initiated monosynaptic tracing, I will then explore the link between subpopulation specific connectivity and tuning properties. This project will greatly contribute to the understanding of how cortical neuronal subpopulations interact to encode sensory information. I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Professors Kenneth Harris and Matteo Carandini.

Keywords: vision,cortex,calcium imaging,neuronal subtypes,in situ transcriptomics,synaptic networks