Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeted therapy to block melanoma progression through peptide phage-display profiling of melanoma cells and derived extracellular vesicles (Target-MelaneX)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

Melanoma, the deadliest form of skin cancer, is strongly influenced by environmental factors such as UV radiation from ozone depletion. In 2022, there were 331,722 new melanoma cases globally, and by 2040, cases are expected to rise by 50%. A major challenge in treating melanoma is its ability to metastasize, especially when therapeutic targets are unclear or when tumors develop resistance to existing treatments. Recent research findings have identified the nerve growth factor receptor p75NTR as a key player in melanoma progression, invasion, and metastasis, especially in highly metastatic melanoma cells. This project aims to target p75NTR in melanoma cells and extracellular vesicles (EVs) to inhibit melanoma progression. While p75NTR role has been identified in melanoma cells, its role in tumor-derived EVs—responsible for cell communication and metastasis—remains under-explored. This project aims to block p75NTR in both melanoma cells and EVs, where co-receptors and co-effectors availability and cellular interactions differ from that within cells, potentially offering a new therapeutic approach. Leveraging phage display technique, the project will identify peptide ligands specific to p75NTR on melanoma cells and EVs. Outcomes from this Fellowship will benefit several scientific communities, including those working in biomaterials and peptide sciences and, cancer, while providing advanced training and career development opportunities for a young researcher at the intersection of targeted cancer therapies, advanced biomaterials design and peptide technology, preparing her for a leadership role in translational cancer research. By addressing both melanoma cells and EVs, this project introduces a dual-targeted strategy with the potential to transform the understanding of melanoma biology and open new avenues for more effective therapies.

Keywords: hyaluronan,peptides,phage display,targeting,melanoma,extracellular vesicles evs,nerve growth factor receptor p75ntr,cell invasion and migration,peptide receptor interactions
Providing 4D LiDAR sensors at scale (LIDWAVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The demand for advanced 3D perception systems is rapidly growing across various industries, from autonomous vehicles to smart cities and industrial automation. Current LiDAR and radar technologies, however, face significant limitations. Traditional LiDAR systems suffer from high costs, complex assembly and susceptibility to environmental interference, while radar systems lack the spatial resolution and instantaneous velocity information needed for many applications. LIDWAVE's revolutionary 4D LiDAR sensor technology, based on Finite Coherent Ranging (FCR), addresses these limitations by leveraging the unique coherent properties of light. This innovative approach extracts both depth and instantaneous velocity information, providing a comprehensive understanding of scene dynamics. The monostatic design, integrating transmitter and receiver on a single silicon photonics chip, eliminates calibration requirements, enhances robustness, and enables cost-effective scalability. LIDWAVE's 4D FCR sensor revolutionizes 3D perception by delivering simultaneous depth and velocity information, providing a complete understanding of scene dynamics without complex post-processing. Its single-chip, calibration-free design ensures robust and reliable performance in challenging environments, while its integrated design enables cost-effective scalability, making advanced 3D perception technology accessible to a wider range of applications. The sensor's superior performance in harsh weather conditions, including rain, fog, and snow, surpasses traditional LiDAR systems, further solidifying its position as a game-changer in the field. This disruptive technology is poised to transform industries by providing a cost-effective, high-performance, and environmentally resilient solution for a wide range of applications. The impact of LIDWAVE's 4D technology extends beyond improved safety and efficiency to encompass economic growth, job creation, and enhanced sustainability across various sectors.

Keywords: 4d lidar,sensor on a chip,monostatic design,photonic chip,finite coherent ranging,high resolution,scalable silicon photonics platform,instantaneous velocity measurement
Extraction of biopolymers from biochemical waste streams to replace plastic binders (WASTE2BINDER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1.95
EU funding (EUR): 1.95
Participants: 1
Project status: SIGNED

The project is focused on OrganoClick’s biobased binders for the nonwoven industry. We are currently selling our biobased binders on a thousand-ton scale to pioneering nonwoven producers which want to become plastic-free. Our biobased binders are based on biopolymers extracted from various side streams in the food industry. A problem is, however, that some of the biopolymers are still much more expensive than the fossil based plastic polymers. The demand for plastic-free nonwovens is high but the price is still a limiting factor for getting a break-in on the really high-volume segments of nonwovens. A way of extracting biopolymers from existing side streams from the food industry in a more cost-efficient way would enhance and grow the market-uptake considerably and lead to that we can move from a thousand-ton scale to a hundred-thousand-ton scale of fossil plastic binders being replaced with our biobased and biodegradable equivalent. Our project aims to revolutionize the supply chain of bio-derived polymers by extracting valuable polymers from waste streams of fungi. The waste is already existing on a large scale. This challenge represents a breakthrough and market-creating innovation due to its unique approach in utilizing fungal waste as a resource for production of biopolymers of high value. The timing is optimal as the world is demanding sustainable and plastic-free solutions, positioning our project at the forefront of environmental innovation. Our commitment to a high-impact scale-up, coupled with the innovation's novelty, advanced TRL, and perfect alignment with market dynamics and technological trends, positions our project as an example of excellence within the bio-derived polymer industry and the polymers application in binders for nonwoven. This unique combination of factors ensures the project's potential to shape the future landscape of natural biopolymer extraction and make a significant contribution to a sustainable and circular economy.

Keywords: extraction,waste,binder
5for25 CHLYDRO: Microalgae Cultivation on a Modular Industrial Scale (5for25 CHLYDRO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 3510000.0
EU funding (EUR): 3510000.0
Participants: 1
Project status: SIGNED

CHLYDRO, founded in 2022, combines nature and technology to create sustainable food solutions through microalgae biomass. This approach addresses climate change and water pollution, promoting a greener future. Specializing in microalgae cultivation, we produce high-value biomass for sustainable products like human and animal food extracts, biofertilizers, and biofuels. By using wastewater and atmospheric CO2, we reduce carbon footprints and supports biodiversity. CHLYDRO aims to make microalgae cultivation profitable in Europe and meet the growing demand for sustainable food alternatives. We plan to demonstrate the scalability of a 5-hectare production plant that is both economically and environmentally efficient. This initiative will address European and global microalgae demand, improve food security, reduce health issues with the nutritional benefits of microalgae, and aid in the decarbonization of Spain and Europe by capturing CO2 and treating wastewater. The world faces challenges: increasing food production by 60% by 2050, addressing climate change, and tackling water pollution. Traditional methods are unsustainable. Food security is a concern with a global population projected to reach 9.3 billion by 2050. Traditional protein sources like meat are inefficient and major contributors to greenhouse gas emissions.The livestock sector accounts for 14.5% of global GHG emissions, driven by land use changes, methane emissions, and resource consumption. CO2 levels have surged since the Industrial Revolution, making reforestation insufficient. Over 60% of EU soils are in poor condition, and water resources are threatened by high nitrogen levels, costing Europe €70 billion annually. CHLYDRO provides a solution that addresses these challenges by using microalgae and aquatic plants to produce sustainable products. This approach tackles food production needs, mitigates climate change, and reduces water pollution, offering a comprehensive alternative to traditional methods.

Keywords: microalgae,sustainable food,climate change,water pollution,bioeconomy,nutritional benefits,carbon footprint,biodiversity,food security,decarbonization,wastewater treatment,biofertilizers
Functionalised Activated Sapphire Thin-disk (FAST) (FAST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: United Kingdom,Germany,Czechia,Lithuania,France
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-07-01
End date: 2029-06-30
Duration (months): 36.0
Total project cost (EUR): 2997897.25
EU funding (EUR): 2997897.25
Participants: 5
Project status: SIGNED

Optical materials are indispensable for modern society reliant upon technology to create and share information, fabricate advanced materials, and study the intricacies of our physical universe. Our Pathfinder science-to-technology breakthrough targets a paradigm shift for fabricating a novel optically active crystal – rare-earth (RE) doped sapphire. Sapphire is an exemplary material, second only to diamond in the Mohs hardness scale and 3rd in the list of the hardest natural minerals – importantly, 1st in this list that can incorporate RE ions into its lattice. In adopting a radically different non-thermal-equilibrium crystal-growth method, namely Rapid Pulsed Laser Deposition (RPLD) we capitalise on an order-of-magnitude higher deposition frequency than regular PLD and, in addition, exploit the ability to incorporate substantially more RE impurity than conventional crystal-growth techniques can achieve. With practically relevant doping concentrations RE-doped sapphire (REDS) promises a step change in critical properties for laser gain elements, especially Yb:sapphire thin disks. A greater than tenfold improvement in laser power is anticipated in like-for-like replacement of a state-of-the-art Yb:YAG thin disk with a Yb:sapphire one. However, we propose additional science-to-technology breakthroughs that will potentially offer a further order-of-magnitude performance enhancement. The first addresses Amplified Spontaneous Emission (ASE), a limit to power scaling thin-disk lasers, whereby we will nanoengineer key surfaces of the active elements to functionalise them and control their optical properties. Functionalising the activated sapphire promises ASE mitigation and aperture scaling opportunities for a new generation of thin-disk gain elements in extreme-power photon engines. FAST lasers, will open new technological opportunities in space science, high-value manufacturing, and transform future directions for laser technology for the rest of the 21st C.

Keywords: pulsed laser deposition,epitaxial growth,physical vapour deposition,yterbium,sesquioxides,sapphire,laser crystals,high power lasers
Magnetic 3D nanowire networks (MIDAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

The scope of this Marie Sklodowska-Curie Action is contributing to achieve a priority goal for the European Commission: the development of resilient materials for Space technology, thus enabling it to achieve a leading position for the European aerospace industry. In February 2022, the EU Parliament flagged that Europe was critically lagging behind in space technology and market up-take competition. Nowadays, the EU is facing the consequences of geopolitical dependencies in energy, semiconductors and access to space. Space environment is harsh and pushes devices to the limits of radiation tolerance, temperature swifts and mechanical loads. Moreover, electronic devices in payloads and platforms must be lightweight and low volume. In addition, they shall not “interfere” with other sensitive electronic equipment by their own electromagnetic emissions. Three dimensional (3D) magnetic networks have the potential for a highly performance, long-life, and lightweight solution. However, precise fabrication of 3D magnetic metamaterials is expensive and hardly scalable. To overcome these challenges, we propose to use magnetic 3D Nanowire Networks fabricated by electrodeposition in self-assembled 3D alumina templates. The MIDAS project (MagnetIc 3D nAnowire networkS) envisages the capacity to decrease and even suppress the ElectroMagnetic Interference (EMI) and to improve the Electromagnetic Compatibility of space electronics, by developing space robust absorbing 3D metamaterials, able to be conformal to Aluminum chassis simplifying their practical implementation and integration within the structures. To achieve so, Dr. L. G. Vivas will receive hands-on training in complementary experimental techniques at the host group of Prof. M. Martin-Gonzalez at the Institute of Micro and Nanotechnology and the secondment group of Dr. R. Sanz at the National Institute of Aerospace Technique.

Keywords: aerospace magnetism,micro magnetism,3d magnetism,electrodeposition,self assembled structures,electromagnetic compatibility
Overcoming hurdles to the diffusion of environmentally sustainable behaviour (ECO-HURDLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

The need for action on tackling climate change has reached a make-or-break moment: we can only deliver on the commitments made in the Paris Agreement if we act now. Given the importance of consumer behaviour in addressing climate change and the urgency for action, accelerating the growth in the adoption of green practices is critical if Europe is to become a climate neutral continent by 2050. However, while the availability and consumption of sustainable product and service options has been growing, the diffusion of these sustainable practices in society has been slow, showing that early adoption of sustainable consumption practices does not sufficiently generalize to similar practices or other consumers. The overarching objective of this project is to study why instances of environmentally sustainable behaviour does not always invite more instances of such behaviour. I will study the hurdles first at the intrapersonal level by looking at downstream consequences of perceptual biases and testing intrapersonal consistency across different consumer domains. Then I will move to the interpersonal level, studying barriers that might prevent consumers from following or mimicking the green behaviour of others. At both levels I will test a number of theoretically justifiable remedies and nudges to correct for these biases. The project findings will provide valuable input in defining policy and strategies to encourage environmentally sustainable consumption and will help consumers in interpreting eco-information and understanding the effects of biases on their own consumer behaviour.

Keywords: environmentally sustainable consumer behaviour,perceptual biases,eco information,green self perceptions,conspicuous consumption,reactance theory
Optimizing sensitization for solid-state triplet-triplet annihilation upconversion (OPTSENTUC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Improving the efficiency of solar cells can have far reaching impacts globally. The proposal ‘OPTSENTUC’, is devised to improve the quantum yield of solid-state triplet-triplet annihilation upconversion(sTTAUC) by optimizing the sensitization process. sTTAUC can be exploited to extend the absorption spectral range of any solar cell and hence can significantly improve single p-n junction solar cell power conversion efficiency beyond the fundamental Shockley- Queisser limit. The first part will focus on understanding the major loss mechanism in sTTAUC- the back transfer of upconverted excitation energy via Förster resonance energy transfer (FRET) - and will try to address it by quantitatively optimizing sensitizer parameters. Based on this study a sensitizer concentration threshold with respect to Förster distance will be established and an annihilator-sensitizer pair with least FRET loss will be identified. The threshold intensity for TTAUC is usually orders of magnitude higher than the solar flux and decreasing sensitizer concentration to reduce FRET will further increase this threshold. The second part of the proposal will address this challenge by coupling the sensitizer absorption with a cavity mode so that the ability of the upconversion system to absorb light will be enhanced. A simultaneous coupling of another mode of the cavity will make sure the outcoupling efficiency is not compromised due to cavity introduction. Thus, enhancing the scope of sTTAUC in real world applications.

Keywords: triplet triplet annihilation upconversion,forster resonance energy transfer,weak light matter coupling
4D Microscopy of biological materials by short pulse terahertz sources (MIMOSA) (MIMOSA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Italy,Germany,Sweden,Canada,Romania
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 3591780.0
EU funding (EUR): 3591780.0
Participants: 12
Project status: SIGNED

Cryo-electron microscopy and tomography have been among the greatest achievements in biological imaging, but these techniques suffer from insufficient chemical resolution. The ultimate goal of MIMOSA is to provide an alternative to tomography at the nanoscale with a high chemical resolution for biological and medical systems, based on Tomographic Atom Probe (TAP). MIMOSA aims to prototype a new TAP triggered by intense terahertz (THz) pulses that are stable at high repetition rates and exhibit versatile and tailored properties. MIMOSA relies on the integration of trans-disciplinary fields in bio-imaging, optics, ultrafast lasers and intense THz sources, big-data treatment and physics of the interaction between THz waves and matter. MIMOSA aims to prototype in parallel an efficient intense THz source based on a new technology with ultrafast high-energy fiber lasers. This source can be used in nano-tomography for biological and medical applications but also as a test platform for a foreseeable commercialization of the THz-triggered TAP. The MIMOSA team members are leaders in TAP development, 3D medical and bio-imaging, ultrafast lasers development with advanced techniques for shaping and control of the optical beam’s properties and theoretical physics. With MIMOSA we are uniquely positioned to succeed and to raise the competitiveness of Europe in microscopy development on the international scene.

Keywords: high resolution 3d microscopy,tomographic atom probe,high energy ultrafast lasers,thz science and technology