Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Feasibility Study for Fleximodo – Smart IoT Sensors with Software for Parking Management (Fleximodo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovakia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Outdated parking management leads to a range of economic, environmental and infrastructural inefficiencies which affect the quality of life in cities. Adoption of smart parking solutions can optimize the use of existing infrastructure and resources, leading to a better service for end-users and optimized operational costs for parking providers. However, existing solutions have limitations that range from inaccurate measurements, weak battery life, sustainability (lack of control of deployed infrastructure) and its reliance on expensive proprietary protocols with no chance for massive deployment that is possible via cutting edge LPWAN of existing cellular networks with nationwide presence. Furthermore, the smart parking market is growing fast: European market is expected to grow by 9.6% CAGR during 2018-2024, the North American will grow by 18,4% CAGR in the next 3 years. Therefore, GOSPACE utilized its expertise in space research and IoT-networks to develop Fleximodo, a superior IoT parking solution. As a result, compared to competitors, Fleximodo is the only solution with manufacturing and connectivity standards (LPWAN) expected from components used for space satellites. Its detection technology relies on 3-axis magnetic field and unique corrective algorithm detecting occupancy with a nearly 100% success rate. GOSPACE parking detectors are compatible with all major IoT networks and provide seamless firmware updating. The authorization and authentication features, applicable in multiple use-cases, further position GOSPACE to fill the gap in the on-street smart parking market. Lastly, each detector is shielded in a special case which is extremely durable & resistant to any violation and extreme conditions.The main objectives of Phase 1 of SME Instrument are to develop an elaborate feasibility study including through user needs analysis, a pilot test, partner strategy, and an elaborate business plan, which are crucial for Fleximodo’s successful commercialization.

Keywords: smart parking,internet of things,parking detectors
Making life-saving cancer therapies more widely available by simplifying production processes, reducing costs and enhancing patient safety through its patent-protected biomimicking mesh material. (ImmunoGrow)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Lifesaving cell-based CAR-T therapies have achieved remission rates of up to 83% for patients with the most aggressive and untreatable cancers. These therapies harness a patient’s own genetically engineered immune cells to target cancer cells. However, manufacturers are struggling to produce these individualised treatments at scale resulting in prohibitive prices as high as $475,000 per treatment. Unless solutions that address these limitations are provided, publically-funded EU healthcare systems & citizens will be priced out of these life-changing therapies. The challenges they face include poor cell growth performance due to patient sample variability, limitations associated with equipment adopted from the research lab that require costly skilled labour, costly consumables and expensive cleanroom infrastructure. Compared to the gold standard, Dynabeads, initial testing has shown that the ImmunoGrow technology produces an 8x higher cell yield which helps to save the sickest patients who have limited cells and significantly reduce the cost to manufacture these therapies by simplifying the process, reducing the requirement for skilled operator input and making this step both ‘closed’ and automated. ImmunoGrow achieves this through its patent-protected mesh structure that mimics the natural growth conditions cells encounter in the body. Grey Matter Technologies (‘GMT’) Ltd. is seeking support to help fund trials with two identified customers as well to help it to conduct an independent set of tests on the product’s performance. Both these trials, as well as an associated business plan or feasibility study, will be core to the raising of a seed round of €500,000 in 2019 to further develop the technology with the release of a full-scale product anticipated for Q3 2021. GMT expects to capture 15% of the $600mn addressable T-Cell Activation market in 2030. In doing so, it will make these life changing treatments cheaper, safer and more widely available.
Pan-European Training, research and education network on Electromagnetic Risk management (PETER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Germany,Belgium,Belgium,Belgium,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 4039626.6
EU funding (EUR): 4039626.6
Participants: 19
Project status: SIGNED

Sophisticated electronic technologies are increasingly used in mission- and safety-critical systems where electromagnetic interference (EMI) can result in substantial risks to people and the environment. Currently, EMI engineering follows a rule-based approach, which is unable to cope with complex modern situations. With this rules-based approach, during the design stage, guidelines are prescribed, which result in the application of a set of mitigation techniques, which are verified in the finished product against standards. This rule-based approach is costly, but with no guarantee of the required performance. This is particularly so for sensitive medical applications or the full-autonomous systems that are becoming ever-more common in our society. What we need is a risk-based approach, which is what PETER, the Pan-European Training, Research & Education Network on Electromagnetic Risk Management, will provide. PETER will train 15 young engineers in topics related to the development of high-tech systems that maintain reliability and safety over their full life-cycle, despite complex EMI, such as in hospitals or transport systems. This will be achieved using best practices and state-of-the-art EM engineering, reliability engineering, functional safety, risk management and system engineering, to create the risk-based EMC approach. The multidisciplinary, multinational doctoral training program will provide the researchers with experience and allow them to develop and in time lead their own area of research. PETER is closely aligned with the high-priority areas of the EU, addressing many Horizon 2020 thematics, e.g., Industrial Leadership (Advanced manufacturing and processing), Societal Challenges (Smart, green and integrated transport; Secure, clean and efficient energy) and Excellent Science. But the most important output of PETER will be 15 highly qualified people who have been trained to tackle many of the problems now being faced by European industry.

Keywords: electromagnetic compatibility,electromagnetic interference,risk management
Simulations for Inertial Particle Microfluidics (SIRIUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1499290.0
EU funding (EUR): 1499290.0
Participants: 1
Project status: SIGNED

Cancer and bacterial infections are projected to kill 18 million people worldwide annually by 2050. Fast and reliable diagnostics are essential for early and targeted treatments. Microfluidics is at the heart of the miniaturisation of diagnostics, enabling novel portable and low-cost point-of-care devices. Inertial particle microfluidics (IPMF) is a novel and competitive method with applications in cancer cell and bacteria separation. Yet, the physics behind IPMF is not well understood, making progress slow and costly. Novel design rules are in urgent need to avoid trial-and-error experiments. I will numerically investigate the underlying physical mechanisms and develop the first predictive toolkit for engineering applications of IPMF. In particular, I will address five ambitious challenges in SIRIUS: 1. Develop an accurate numerical model for IPMF. 2. Understand the impact of particle softness. 3. Investigate the effect of finite particle concentration. 4. Improve the currently low separation efficiency of small particles. 5. Develop a toolkit to enable simulation-driven design. These objectives are feasible through novel numerical approaches based on the lattice-Boltzmann method and state-of-the-art high-performance computing. SIRIUS will pursue an innovative simulation campaign, validated with existing experimental data, to generate both physical insight and scaling laws for simulation-driven design. For the first time, SIRIUS will produce robust numerical methods for IPMF. My pioneering research will uncover the physics behind particle separation and culminate in a design toolkit for IPMF engineers. SIRIUS will fill a critical gap and open up an entirely new research field: “Simulations for inertial particle microfluidics”. Results of SIRIUS will be published as open-source codes, open-access articles, and open data. This will ultimately enable faster, less costly and more innovative research in the field of microfluidics for diagnostics.

Keywords: particle separation,simulation driven design,inertial microfluidics,lattice boltzmann method,fluidic devices,suspensions
Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Ireland,Italy,Italy,Italy,Germany,Ireland,France,France,France,France,France,Netherlands,United Kingdom
Call: Clinical research on regenerative medicine (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 5999000.0
EU funding (EUR): 5999000.0
Participants: 21
Project status: CLOSED

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential candidates to overcome this clinical short-coming. Autologous adipose-derived mesenchymal stromal cells (ASCs) are attractive for cellular therapy given the abundance of tissue, high frequency of MSCs and minimally invasive harvest procedure. The EU consortium ADIPOA has shown in a ‘first in man’ 2-centre Phase I safety study that intraarticular injection of a single dose of autologous ASCs to the knee (18 patients, 12 month follow-up) was well-tolerated, had no adverse effects, and resulted in an improvement in pain score and functional outcome. ADIPOA2 will deliver a large-scale clinical trial in regenerative medicine for OA. The purpose of the project is to design and implement a phase IIb study to assess the safety and efficacy of autologous (patient-derived) ACSs in the treatment of advanced OA of the knee. The cells will be prepared from samples of adipose tissue harvested from patients by lipoaspiration. ADIPOA2 will comprise a multi-centre, randomized clinical trial comparing culture-expanded, autologous adult ASCs in subjects with knee OA with another widely used therapeutic approach for knee degeneration (injection of Hyaluronan). There are two large elements of the study: (1) the production of consistent batches of high-quality autologous ASCs under GMP-compliant conditions and (2) delivery of these cell doses to patients in a trial which will meet all national and European regulatory and ethical standards and which will have sufficient statistical power to provide an unambiguous and definitive assessment of safety and efficacy.

Keywords: stem cells,arthritis,phase 2b clinical trial,mechanism of action,regulatory compliance,potency test,prediction of efficacy,sops
Next-generation of high performance, ultra-light carbon nanotube based heaters (Carbon Heaters)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2014-12-01
End date: 2016-02-29
Duration (months): 15.0
Total project cost (EUR): 149995.0
EU funding (EUR): 149995.0
Participants: 1
Project status: CLOSED

We have created a high performance, ultra-light and ultra strong carbon nanotube (CNT) film electrical heaters. Compared to traditional heating materials, they are super fast (reach the terminal temperature in less than (1/4s), lighter (100x), resistant to corrosion (concentrated acids do not affect them) and cheaper (a fraction of the cost). The heaters are fully scalable from nano-sized devices to full size applications on commercial aircrafts. Previous experiments involved a range of material sizes, from transformations on a molecular level to rapid de-icing of a model aircraft . The performance of the heaters revealed a 12,000,000% advantage by weight over the current most common heating alternative: resistive wires made of nickelchromium alloy. In this proposal, we show how this invention could alleviate the problem of aircraft de-icing.

Keywords: heater,carbon nanotubes,graphene,functional materials
Breeding forage and grain legumes to increase EU's and China's protein self-sufficiency (EUCLEG)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Switzerland,Norway,Belgium,China,Norway,Finland,Sweden,Switzerland,Serbia,Sweden,Serbia,Belgium,Belgium,France,France,France,France,Czechia,United Kingdom,Denmark
Call: A joint plant breeding programme to decrease the EU's and China's dependency on protein imports (H2020-SFS-2016-2, 2016)
Start date: 2017-09-01
End date: 2021-12-31
Duration (months): 52.0
Total project cost (EUR): 7788192.5
EU funding (EUR): 5000000.0
Participants: 42
Project status: CLOSED

EUCLEG aims to reduce Europe and China’s dependency on protein imports by developing efficient breeding strategies for the legume crops of major economic importance in human food and animal feed. The objective is to improve diversification, crop productivity, yield stability and protein quality of both forage (alfalfa and red clover) and grain (pea, faba bean and soybean) legumes. Using diverse and extensive genetic resources and taking advantage of advanced molecular tools, EUCLEG aims to identify and develop the best genetic resources, phenotyping methods and molecular tools to breed legume varieties with improved performance under biotic and abiotic stresses in the representative European and Chinese agro-ecological areas. The potential for new uses of forage species for human nutrition will be explored. Searchable databases will be developed or built to host passport, agronomic and genetic data facilitating exchanges and use of genetic resources. The evaluation of genetic resources in multi-site trials will allow to broaden the breeding material and extend agro-ecological adaptation. The genetic architecture of key breeding traits will be analysed using association studies in order to identify molecular markers related to phenotypic traits. Finally, genomic selection strategies will be assessed for their potential to improve genetic progress. Practical tools for genotyping, data management and calculation will be provided to breeders to implement marker-assisted selection and genomic selection leading to the creation of new varieties in the long-term. The partnership gathered in EUCLEG, combining public institutes and private companies of Europe and China, guaranties the transfer of knowledge from research to seed industry.

Keywords: protein yield,quality,yield stability,feed,food,disease,drought,molecular breeding,phenotyping,genotyping,genetic resources,association genetics,genomic selection,climate change,database
Wage transparency in companies (WAGETRANS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

How much information about the wage structure should a company provide to its employees? Existing research in economics does not provide clear recommendations in this respect. Transparent information about the wages within a company may have a positive impact on employee satisfaction and motivation, because wage secrecy creates distrust and favours discriminatory practices. Yet, it is unclear whether the benefits of wage transparency are larger than the potential harm: Unequal wage profiles, if made transparent, trigger social comparisons among employees that may destroy work motivation and increase the likelihood of leaving the firm. So far, there is little systematic research on the impact of wage transparency as an element for incentive system design. The goal of this project is to significantly enhance the understanding of the role of wage transparency in two work packages that focus on the question how employers and employees manipulate and respond to the wage information in the company environment. In work package 1 (NEGOTIATION), I will analyse how transparency affects the wage negotiation process between employers and employees, the resulting wage profiles and subsequent working performance. In work package 2 (NORMS), I will study how the prevailing social norm within the firm changes the impact of transparency on the wage structure and working motivation. My project contributes to the emerging field of economic design, combining insights and methods from behavioural and experimental economics, social psychology and management research. The results from my project will yield important new insights for fundamental research, in particular concerning the emergence and importance of relative comparisons at the workplace and their interaction with social norms. Also, the results will have direct implications for incentive system design in practice and for policy measures against discriminatory remuneration practices in the EU and on the national level.

Keywords: wage transparency,economic design,economic experiments,incentive systems,negotiations,social comparisons,social norms,working performance
Ice-ocean interactions during Heinrich Events in the Labrador Sea (IceLab)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Northern hemisphere ice sheets are particularly vulnerable to climate change as the Arctic is warming twice as fast as the rest of the planet. Scenarios of future ice sheet stability, however, are associated with significant uncertainty, due to a lack of understanding of the relevant internal climate feedbacks. These processes involve ocean-ice sheet interactions and the effects of sea ice on the terrestrial cryosphere. With increased societal concerns over rising sea levels, it is more than ever important to understand the implications of climate change for ice sheet stability. The key lies in understanding the response of past ice sheets to climate change. Prominent episodes of past ice-sheet collapse are so-called Heinrich events during the last glacial period, originating in Hudson Strait. While modelling studies have long hinted at the importance of sea ice in the Labrador Sea for subsurface warming and ocean induced melting during Heinrich events, this has not been shown using proxy methods. My project will investigate the links and feedbacks of sea ice, ocean circulation, subsurface warming, and ice-sheet collapse in the Labrador Sea to determine the role of the coupled cryosphere-ocean system for ice sheet stability across. Additionally, the effect of enhanced freshwater discharge on the system will be documented and a spatial-temporal map of North Atlantic sea ice dynamics across Heinrich events will be constructed. I will apply an integrated approach of organic and inorganic geochemistry, using sea-ice biomarkers, foraminiferal isotopes, and foraminiferal trace metals (i.e. Mg/Ca) in combination with state-of-the-art dating and correlation techniques. The new records will provide important clues with respect to a potential oceanic trigger of Hudson Strait iceberg surges during Heinrich events as well as advancing our understanding of the coupled cryosphere-ocean system, vital to accurately predict mass loss from the Greenland ice sheet in the future.

Keywords: sea ice ocean continental ice sheet interactions,heinrich events,ice sheet stability,labrador sea,biomarkers,foraminifera