Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ecological intensification in horticulture: Increasing crop quantity and quality by understanding relationships between functional diversity, ecosystem services and genotype-specific traits. (ECO-INTENS-HORT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-15
End date: 2026-09-14
Duration (months): 41.0
Total project cost (EUR): 195152.23
EU funding (EUR): 195152.23
Participants: 1
Project status: SIGNED

Biodiversity is a vital resource for humanity, providing essential ecosystem services for food production. Agriculture is a main driver of biodiversity loss, thus jeopardising the biodiversity-based ecosystem functions and services agriculture itself depends upon. The demand for agricultural products is rising, so alternatives to conventional intensification are urgently needed. Ecological intensification strengthens natural processes through regulating and supporting ecosystem services instead of using human-produced inputs. Current research on temperate and tropical crops indicates that many crop systems experience pollination deficits, limiting crop production. Effective pollinators have been identified for some crops, but we lack a mechanistic understanding of how functional biodiversity translates to gene flow across plantations, and thus crop yield and quality. How floral traits of different crop genotypes affect gene flow has also received little to no attention. This interdisciplinary project is designed to create species-specific data showing how pollinator species move pollen, and which genotype(s) of pollen they carry, as this determines yield and nutritional quality. Further, this project is dedicated to assessing whether mixed cropping of genotypes can affect pollination services by measuring genotype-specific floral traits and associating traits with variation in pollinator visitations. This will create a mechanistic understanding of pollinator movement, necessary to develop ecological intensification strategies that use genotypes with specific flower traits to strategically attract and retain the most efficient pollinators. The outcome of this research has scientific, economic, and societal impact, by delivering strategies to make food systems more productive while maintaining biodiversity and environmental sustainability, in line with the UN Sustainable Development Goal Zero Hunger, instead of succumbing to the rising demands on agriculture.

Keywords: ecosystem services,crop production,horticulture,pollination,gene flow,genotypes,floral traits
Metabolic Gut Inflammation in Crohn's disease (MEGI CD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1493875.0
EU funding (EUR): 1493875.0
Participants: 1
Project status: SIGNED

The rising incidence of inflammatory bowel diseases such as Crohn?s disease (CD) has become a global health care issue in the 21st century. The complex genetic underpinning is increasingly appreciated, while environmental cues and specifically a Western diet are suspected to impact development and course of disease. Mechanistic insights that would support this assumption remain scarce and specific nutrients that trigger a flare are unknown. Westernisation of dietary habits is partly characterised by enrichment of long-chain fatty acids, which fuel metabolic inflammation of tissues beyond the gut. Here, we propose to establish the concept of metabolic gut inflammation as a fuel for CD. By analysing transgenic mice, human CD organoids and two independent CD patient cohorts, we seek to establish how dietary polyunsaturated fatty acids (PUFAs) affect gut inflammation and disease course. The proposed work is based on our previous observations that dietary PUFAs trigger a chemokine response and Crohn?s-like enteritis in mice, which is restricted by intestinal epithelial Glutathione peroxidase 4 (GPX4). GPX4 is an evolutionary conserved anti-oxidative enzyme which shows impaired activity in CD epithelium. The proposed work will identify how dietary PUFAs elicit gut inflammation in mice and which epithelial lineage executes the inflammatory response. In a next step, I propose to establish a critical crosstalk between GPX4 and metabolic hubs in gut epithelium to provide a basis for the concept of metabolic gut inflammation. Finally, we seek to translate findings by establishing that PUFAs evoke an inflammatory response from CD epithelium, and that PUFA intake impacts disease course. MEGI CD comprehends basic and translational science to set the basis for novel therapeutic strategies in a complex illness that requires better treatment modalities. The study will prove the concept of metabolic gut inflammation as a major driver of human CD, a basis for nutritional therapy.
From Housing Inequality to Sustainable, Inclusive and Affordable Housing Solutions (EqualHouse)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Ireland,Belgium,Hungary,Netherlands,Sweden,Greece,Poland,United Kingdom
Call: Addressing housing inequalities in a sustainable, inclusive and affordable way (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2999185.0
EU funding (EUR): 2999184.75
Participants: 12
Project status: SIGNED

Highly ambitious in its objectives and scope and innovative in its focus, conceptualisation and methodology, EqualHouse is the first research project to integrate all dimensions of housing inequality into one transdisciplinary and transnational research design. By analysing the many aspects of housing inequality, hitherto largely studied separately, it will make key contributions to understanding of housing inequality and how it can be tackled and respond comprehensively to the work programme priorities. EqualHouse is designed to identify the most significant dimensions of housing inequality across Europe, clarify their scale, form, causes and consequences and provide local, regional, national and European policymakers with robust guidance on how to address these inequalities in a sustainable, inclusive and affordable way. It will analyse the scale, form and dynamics of housing inequality comprehensively across the EU27 and UK, identify its new, acute and intersectional forms and explore its interaction with income and wealth inequality. The policy, regulatory, service and finance drivers of (and solutions to) housing inequality will be examined, in both national and international perspective. EqualHouse will propose solutions to address acute, intractable and new forms of housing inequality such as unaffordability, homelessness among refugees and migrants, labour market related housing inequalities and energy poverty. EqualHouse starts by considering policymakers and implementers concerns and involves them as partners in co-creating both the research and solutions to housing inequality, rather than relegating the production of these solutions to the project end-stage and generating and communicating them in a top down manner. To achieve these ambitious objectives, EqualHouse brings together a diverse and expert team of academics from across Europe and disciplines and housing policymakers, providers and end-user representatives.

Keywords: social housing,financialisation of housing,housing allowances,income,wealth,taxation and fiscal policy,homelessness,land for housing,energy retrofit,social innovation,community land trusts
Auto-adaptive Neuromorphic Brain Machine Interface: toward fully embedded neuroprosthetics (NEMO BMI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France,Bulgaria,Netherlands,Switzerland
Call: Tools to measure and stimulate activity in Brain Tissue (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2954065.88
EU funding (EUR): 2951565.88
Participants: 5
Project status: SIGNED

Nearly 746,000 people sustain a spinal cord injury every year, with dramatic human, societal and economical cost, leading to impairment or even complete loss of motor functions. Motor Brain-Machine Interfaces (BMIs) translate brain neural signals into commands to external effectors. BMIs raise hopes that limb mobility may be restored, providing patients with control over orthoses, prostheses, or over their own limbs using electrical stimulation. In spite of spectacular results, taking neuroprosthetics into daily practice has proven difficult. Currently, neuroprosthetics are restricted to assisted trials in laboratories, and require regular retraining of a decoder in a supervised manner within controlled environments. They include various components (recording device, antennas, base station, computers connected to effectors, etc.) that are complicated to install and to use. Building on the consortium's unique experience in clinical chronic BMIs, the project will address major methodological and technological breakthroughs to achieve the first assistance-free motor neuroprosthetics system. NEMO BMI project will conduct the exploration of assistance-free and easy to use portable neuroprosthetics including wireless neuronal activity recorder, a real-time neuronal activity decoder based on integrated technologies, and a spinal cord stimulator. A first objective is the crucial improvement of usability, by introducing an auto-adaptive framework to train the decoder in an adaptive manner during the neuroprosthetics unsupervised use. Brain-guided spinal cord stimulation activating patients’ limbs with an automatic stimulus pattern optimization is the second project objective. A third objective is the exploration of miniaturized embedded solutions by taking advantage of a novel neuromorphic hardware architecture. NEMO BMI technologies will be studied offline and online in two ongoing clinical trials, and will be critical to specify the next-generation assistance-free BMI.

Keywords: neuroprosthetics,brain machine interface,brain spine interface,auto adaptive decoder,neuromorphic algorithms,spinal cord stimulation,electrocorticography,miniaturized integrated circuit
IDEFIX Multiorgan toxicity and efficacy test platform (IDEFIX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2022-11-01
End date: 2024-08-31
Duration (months): 22.0
Total project cost (EUR): 2496073.25
EU funding (EUR): 2496073.0
Participants: 1
Project status: CLOSED

To address the critical problem of the failure of animal testing to predict drug effects (toxicity and efficacy) in humans, Cherry Biotech develops a breakthrough organ-on-chip/MPS solution based on microfluidic technology. Using human tissue, our IDEFIX technology mimics multiorgan physiology and physiopathology. Our MPS platform aims to be the new standard as an alternative to animal experimentation in preclinical studies. Indeed, our solution succeeds in tackling all major industry bottlenecks: seamless adaptability to current workflows, compatibility with all standard multiwell cell cultures and tissues, as well as full microenvironment control and measure while providing a state-of-the-art reconstruction of complex tissues (vascularisation, immune system, circulating metastasis, multiorgan interconnection). This is now achievable by combining the patent-pending gas mixers technology (FR2109230, TRL-3 coming from H2020-FET-OPEN project ELECTROMED) with Cherry Biotech proprietary microfluidic technologies in gas enrichment and simultaneous liquid flow (EP3712244; FR3094012; US2020299631) and our unique know-how in tissue engineering. Within the Transition project, the IDEFIX demonstrator will be completed as a modular platform, with stackable modules (gas, flow, temperature, biosensing, microscopy & imaging control), allowing users to customise the platform according to their respective needs and budget. The final qualification will be conducted in relevant environments, with two European pharmaceutical companies and a hospital/research centre using vascularized liver, adipose and breast cancer tissues. We will test our models to predict the efficacy and toxicity of various known molecules and compare them to previous preclinical animal experimentations and clinical results (retrospective study). By the end of this project, the IDEFIX demonstrator will reach TRL-6, be investment-ready/IRL-7, and be prepared for pre-commercialisation to early adopters.

Keywords: microphysiological systems,in vitro toxicology,drug development,technological innovation
Reliable and Efficient Dual Fuel System for Civil Protection during Natural Disasters using HT-PEM Technology (RESCUE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Greece,Denmark
Call: Portable fuel cells for backup power during natural disasters to power critical infrastructures (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 5831777.58
EU funding (EUR): 4983490.08
Participants: 6
Project status: SIGNED

This proposal entitled “RESCUE – Reliable and Efficient Dual Fuel System for Civil Protection during Natural Disasters using HT-PEM Technology” is about the development and the demonstration of a fuel cell system which allows the operation using 100% of hydrogen and additionally using methanol and assures 50 kW of electrical power. The containerised and modular design in combination with the duel fuel approach leads to an application flexibility for various important facilities during natural disasters like the civil protection with different energy requirements. The HT-PEM technology is characterised by increased operating temperature of around 160 °C and enables a simplified cell design and operation regarding water management, heat rejection and direct use of reformates. After system requirements (WP2), the fuel cell module equipped with the fueling possibilities will be constructed and tested in laboratory environment (WP3). After fuel cell and fuel container contructions (WP4), the system integration (WP5) considering safety and transport certification requirements (WP2/9), demonstration using defined load profiles and conditions with performing grid integration is planned (WP6). Testing for at least 2,000 hours on site of a civil protection organisation shows the system capabilities and completes the project (WP7). State-of-Health against the criterium of system efficiency and fuel flexibility on system and on fuel cell level is analysed and accompanies the whole project duration (WP8). Dissemination and exploitation are mandatory in this project (WP10).

Keywords: hydrogen,methanol,fuel cells,ht pemfc
Promoting Understanding and Lifelong learning Successful Education through the ARTs and culture (PULSE-ART)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Greece,France,Malta,Latvia
Call: Arts and cultural awareness and expression in education and training (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 3183147.5
EU funding (EUR): 3183147.5
Participants: 10
Project status: SIGNED

PULSE-ART will produce compelling evidence illustrating the positive impact of arts in education for the enhancement of cultural expression and awareness (CAE). At the heart of this initiative lies the concept of integrating art, culture, and heritage institutions, including museums, galleries, cultural centres and overall CCIs, into the educational framework. This integration aims to effectively address the deficiencies of the educational system, hindering the improvement of CAE through the arts. Reference materials will be created and integrated into the Arts in Education for Cultural Awareness Observatory, including a Competency Framework, a Professional Development Programme and a self-reflection tool, which will be validated and tested through 7 case studies in 7 countries using different art techniques with a lifelong learning perspective. Collaborative Hubs between educational institutions, spanning all levels of education, and art and cultural heritage organisations will be created to bridge the identified gaps through innovative and tailored methodologies of arts in education, leveraging the expertise and fostering partnerships. PULSE-ART will guarantee the inclusion of all Children & Young people, with the overarching objective of fostering democracy and civic engagement throughout Europe. Multi-stakeholder engagement at different levels (European, national and local), capacity building, co-creation and mutual learning are key elements of PULSE-ART. The consolidation of local partnerships through the case studies will allow accounting for different educational systems and local contexts, embedding intercultural, inclusivity and gender aspects in the research, while the use of a variety of art techniques in different contexts will enrich the validation of the produced methodologies, products and research outcomes. National action plans and a European policy brief will inform policies to support the inclusion of arts in education to increase CAE.

Keywords: cultural awareness and expression,arts,education,mutual learning,competente framework,professional development programme,multi stakeholder engagement
Resilient cross-domain cooperative control of heterogeneous multi-agent systems composed of UGVs and FWM-UAVs (RECOVER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The research action involves an experienced applicant, Dr Qing-Hao Zhang, under the supervision of Dr. Chongfeng Wei for 24 months to work on the project “Resilient cross-domain cooperative control of heterogeneous multi-agent systems composed of UGVs and FWM-UAVs” (RECOVER) at the James Watt School of Engineering, University of Glasgow in the UK. The overall aim of the project is to develop resilient cross-domain cooperative control strategies such that heterogeneous multi-agent systems (MASs) composed of unmanned ground vehicles (UGVs) and flapping wing micro unmanned aerial vehicles (FWM-UAVs) can maintain consensus and formation under uncertainties and external disturbance. RECOVER will fill the existing knowledge gap by establishing novel and distinctive cross-domain models and designing resilient and robust cross-domain cooperative controllers. In RECOVER, in case the systems are with uncertainties and external disturbances, the proposed controllers are able “recover” the systems to the expected consensus and formation state in different domains. Firstly, the innovative models for heterogeneous MASs will be developed (WP1). Based on WP1, the resilient cross-domain distributed consensus and formation control protocols will be designed for heterogeneous MASs with mixed uncertainties (WP2). Based on WP2, the cross-domain distributed adaptive disturbance detectors and the high-performance resilient and robust control protocols will be given (WP3). Then, a comprehensive platform composed of a simulation platform, physical experiment platform and cloud control platform will be built to assess the effectiveness of the results in WP1, WP2 and WP3 (WP4). During and after RECOVER, dissemination, outreach and research activities will be undertaken to share the research findings with different target audience (WP5), maximizing the impact and practical application of the RECOVER's outcomes.

Keywords: robust control,singular system,resilient control,heterogeneous multi agent systems,unmanned vehicles