Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using Topology To Revolutionize Atrial Tachycardia Treatment (AT-TOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Atrial tachycardia (AT) is a prevalent form of supraventricular tachycardia that can have detrimental impacts on a person's health. The complexity of anatomical reentry patterns and unclear nomenclature hinders precise diagnosis of AT and makes optimal treatment challenging and error prone. Suboptimal treatment can result in severe outcomes such as heart failure, stroke, and pacemaker implantation due to overablation-induced atrial dysfunction. In this proposal, we introduce a diagnostic tool called Directed Graph Mapping (DGM), which offers a unique classification system based on clear and precise mathematical criteria using topological principles, allowing for the accurate diagnosis and differentiation of various types of AT. DGM can automatically analyze a given case of AT, providing consistent and reliable results, paving the way for the optimization of the ablation strategy. DGM can not only diagnose the current AT but also predict hidden slower ATs, which might appear depending on the chosen ablation target. By being able to predict the hidden ATs, we can revolutionize the treatment of ATs, as these hidden ATs can be treated already after the measurement of the first anatomical map. Therefore, our tool holds the potential to significantly expedite the ablation procedure. We propose to conduct a prospective study involving a minimum of 15 hospitals in Belgium that specialize in AT ablations to further validate the effectiveness and sustainability of our proposed solution while involving a broad range of electrophysiologists. We aim to publish our results in a high-impact journal. We secured the intellectual property rights of our proof-of-concept through two patents, and by discussing with electrophysiologists, we learned that their interest in DGM influences mapping systems. If they recognize the value of DGM for treating AT, mapping companies may adopt the technology through a licensing agreement, which is the final goal of this proposal.
Producing Green Hydrogen Using Power of Ocean Waves (GreenH2Wave)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-08-01
End date: 2024-07-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The main objective of this project proposal is to boost the Technology Readiness Level (TRL) of the novel Concept of Floating Dual Chamber Oscillating Water Column (FOWC) device. FOWC is a kind of Wave Energy Converter (WEC) system that captures energy of waves and converts it into electricity. The generated electricity is used to produce green Hydrogen from the sea water. The produced Hydrogen is stored inside the internal tanks of the device to be used as the “clean fuel” by the next generation of ships. The idea of this system is the outcome of more than a decade of R&D activities carried out in a prestigious European University to make the WEC devices an economically viable solution to produce clean energy. This innovative solution is the “first and only” WEC in the market that can act like a “floating fuel station” for ocean going ships to reliably produce their clean fuel demand in the middle of oceans with affordable cost. Hence, this technology could play a prominent role in the supply chain of the decarbonizing marine transportation sector that destructively produces 3% carbon emissions in the World. At the moment, this technology has the maturation level of TRL 3. It is planned to perform a further optimization process on the conceptual design of this technology under the scope of this project proposal which allows concluding TRL 3 stage of development. Complementary laboratory tests will be carried out on the optimized model and the new Intellectual property (IP) will be submitted concerning the optimized design. The other main objective of this project proposal is to enhance coordination and marketing skills as well as extending the network of the CEO & Co-Founder of the company and her team according to the unique environment, coaching programme and tailored training session opportunities provided for European Women leaders under the scope of Women TechEU Programme.

Keywords: renewable energy,wave energy converter,technology development,clean fuel for ocean going ships
Advanced Sustainable Biofuels Production from Purified Microalgae and Oleaginous Yeasts via Integrated Solar Hydrothermal Liquefaction (SUNFUSION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Greece,France,Germany,Türkiye,Norway,Serbia
Call: Next generation of renewable energy technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2999389.36
EU funding (EUR): 2999389.36
Participants: 10
Project status: SIGNED

SUNFUSION endeavors to comprehensively address a novel process of microalgae and oleaginous yeasts conversion into shipping and aviation biofuels, by advancing state-of-the-art core technologies: (i) innovative PBR and open raceway ponds for microalgae and yeasts cultivation and optimization; (ii) a concentrated solar thermal (CST)-coupled continuous hydrothermal liquefaction (HTL) reactor with solar energy covering the thermal needs of the process; (iii) a solar-aided thermal energy storage (TES) system which at later stages will be fully integrated to the overall process; (iv) hydrotreatment units to obtain the final, advanced sustainable biofuels; (v) recovery of gaseous and aqueous streams from HTL and synergistic cultivations of microalgae and yeasts that will be recycled to the microalgae cultivation leading to a zero emission and zero waste process. HTL is a thermochemical process used for the production of sustainable biofuels from the depolymerization and repolymerization of highly moist organic biomass, having the inherent advantage of avoiding the cost-intensive part of biomass drying. These points will introduce high-risk/high-return novelties that will play an impactful role in forwarding the process subcomponents to TRL 4. At least 7 L of biocrude from microalgae and 1 L from yeasts are planned to be produced and upgraded. A testing period of above 12 months will take place under on-sun conditions at temperatures exceeding 350oC, with the solar-to-biocrude energy efficiency target set to exceed 50%, which is an ambitious number that will allow the sustainable transformation of solar energy to energy carriers in the form of biofuels. Finally, an overall process assessment will take place to evaluate the technology in terms of technical, economic and environmental aspects. The visionary concept beyond SUNFUSION project envisages the integration of the main components of the process in a mobile platform that will be operational in off-grid places.

Keywords: concentrating solar technologies,microalgae cultivation,oleaginous yeasts,biomass valorization,solar fuels production,biofuels upgrade,marine fuels,aviation fuels,saf,thermal energy storage
O Social Groups, Where Art Thou? A cross-national and longitudinal analysis of the place of social groups at the core of the party-voter representative linkage (GAPREP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The party-voter representative linkage is central to modern democracies. Because political parties, once in office, steer fiscal and social policies, the social groups they claim to represent in their group appeals matter for distributing tangible public goods and specially the equitable treatment of minority groups by the government. While many party politics studies are devoted to parties’ policy appeals and their role in political representation, group appeals have received little attention thus far, leaving a theoretical and empirical gap. Recent studies begin to address this oversight but these works are still few and limited in scope, using either longitudinal, single-country data, or cross-national, time-limited data. Combining insights from political, communication, and computational linguistics, GAPREP will build a new software library (SL) for the computational analysis of political texts (R package). The SL will then be used to analyse group appeals in more than 950 election manifestos in Belgium, Denmark, France, Germany, Netherlands, Norway, Sweden, and the UK between 1949-2022, building a new and publicly available dataset. Together with cross-national historical survey data on voters’ demographics and party preferences from the 1980s onwards (given available data), advanced statistical modelling will reveal how representative of social groups parties have been over the past 40 years. Pushing scholarship on the party-voter linkage still further, the project will also use a unique vignette survey experiment to study the underlying mechanism of this linkage by examining voters’ reactions to parties’ group appeals. Combining these efforts, findings will illuminate social groups' access to power, and social and political equality. Offering a new perspective on the party-voter linkage, the project aims to positively contribute to voters’ contemporary low levels of political trust, which is central to the healthy functioning of modern liberal democracies.

Keywords: party politics,political representation,group appeals,text as data,computational text analysis
Concept development for a research infrastructure to manage, integrate and sustain large medical cohort studies (INTEGRATE-LMedC)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Norway,France,Spain,Netherlands,Czechia,Italy,Germany,Finland,Belgium
Call: Concept development for a research infrastructure to manage, integrate and sustain large medical cohort studies (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3089593.98
EU funding (EUR): 2999679.16
Participants: 12
Project status: SIGNED

The INTEGRATE-LMedC consortium will develop a new concept to guide and support decision-making for the next-generation research infrastructure (RI) to facilitate efficient utilization and harmonization of large medical cohorts (LMedC), and to accelerate scientific and medical breakthroughs in Europe and beyond. Achievement of the ambitious objectives will only be possible through the integration of 11 highly interdisciplinary partners including established ERIC / ESFRI infrastructures such BBMRI, ECRIN, EIRENE and EBRAINS with unique expertise in conceptualizing and implementing European RIs. The partners will generate a gap analysis to identify what is missing of cohort data and samples, RI tools and services, quality measures, governance models, user needs and the barriers for efficient utilization of these cohorts and RI, including ethical and legal frameworks. To identify IT technologies and architecture for suitable data stewardship and long-term availability of European RIs, the partners will prepare for a feasibility study for federated data analysis of LMedC. The feasibility study will be based on two examples of use-cases: one stroke case using data from medical health registry data and one case using data from longitudinal population-based studies with different technical, legal, and ethical challenges. To ensure availability of data and samples related to existing and future LMedC studies and their re-use for secondary research, the partners will develop a concept outline including a governance plan and guiding principles for data access policies and data protection policy, whilst considering the FAIR principles and ELSI issues. An overarching RI concept to manage, integrate, and sustain LMedC studies will be developed, including an initial financial and operational plan for the implementation of the new RI outlining new services and access opportunities for the research community.

Keywords: new concept,next generation european research infrastructure,large medical cohorts,gap analyses,sound science case,feasibility study design,federated data analysis
(In)Visibility of Illegalized Migrants in the Urban Settings (VIMUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,United States,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 454103.4
EU funding (EUR): 454103.4
Participants: 3
Project status: SIGNED

Illegalized migrants (IMs) in urban settings face complex dynamics of visibility and invisibility, shaped by intersecting social identities like race, gender, class, and religion. While there is a rich body of literature on these heterogeneous experiences, existing research lacks a systematic analysis of how legal and policy infrastructures, along with intersecting identities, create different pathways for marginalization, stigmatization, and recognition within different urban contexts. (In)Visibility of Illegalized Migrants in Urban Settings (VIMUS) addresses this gap by drawing on interdisciplinary perspectives from Migration Studies, Critical Race Theory, Postcolonial Feminist Scholarship, and Urban Studies. It proposes a rigorous and innovative research approach structured around three main objectives: (I) analyzing legal and policy infrastructures through critical discourse analysis, (II) exploring relational dynamics of (in)visibility based on diverse urban contexts through thematic analysis, and (III)assessing different paths of intersecting identities shape (in)visibility of IMs across Boston, Birmingham, Barcelona, and Madrid though Qualitative Comparative Analysis (QCA) based on in-depth interviews with IMs. By challenging traditional binary notions of (in)visibility, VIMUS will generate critical, timely, and cutting-edge contributions to the understanding of urban inequalities and the socio-political dynamics of (in)visibility. The findings will guide policymaking and establish a theoretical framework that addresses the complex dynamics of (in)visibility within the context of marginalization, stigmatization, and recognition. Under the supervision of Prof. Sigona from the University of Birmingham, Prof. Lamont from Harvard University, and Prof. Thomann from the University of Konstanz, the fellowship will support my career goal of securing a tenure-track position in sociology at prestigious universities across the EU, or the UK.

Keywords: irregular migrants,undocumented migrants,intersectionality,comparative sociology,qualitative comparative analysis qca,marginalization,stigmatization,recognition,visibility,invisibility
ab initio PRediction Of MaterIal SynthEsis (PROMISE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1496991.0
EU funding (EUR): 1496991.0
Participants: 1
Project status: CLOSED

ab initio simulation techniques have evolved to the point that we can reliably predict many properties of materials before they have been synthesized. This paradigmatic change has led to databases that contain millions of theoretically predicted materials with desirable attributes. However, all this information is of little use if we cannot predict if these novel materials can be made at all. I will develop a framework based on first-principles computer simulations to predict if and how a material can be made. The proposed approach will boost the success rate of “materials by design”, expedite experiments to create novel materials, and thus greatly enhance the speed of materials discovery. To achieve this goal, computational methods that combine crystal structure prediction, advanced statistical sampling, and state-ofthe- art machine learning techniques will be designed. The whole framework will be benchmarked on model systems with known properties. The resulting software will be made generic and open-source. The computational framework will be used to gain mechanistic insight into the physical processes that control the formation of specific functional materials including high-pressure phases of matter, perovskites, and molecular crystals.

Keywords: computational materials science,ab initio methods,statistical mechanics,machine learning for chemistry and materials,atomistic simulations
Exploring the role of Neuroligin-1 in synapse formation and function (ExploNL1)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. This equilibrium is regulated at the level of individual synapses, which can be either excitatory or inhibitory depending of the type of neurotransmitter released. It is well established that cell adhesion molecules such as neurexins (NRXs) and neuroligins (NLs) play important roles in synapse formation and specification. In humans, several genetic mutations in NLs are associated with Autism Spectrum Disorders (ASD) but how those mutations act in the establishment of those disorders remains unclear. One hypothesis is that mutations found in ASD patients can affect the interactions of NLs to specific protein binding partners and/or alter signaling pathways, which could contribute to disrupt the E/I balance. Interestingly, the host group recently discovered a molecular mechanism in which the phosphorylation of unique tyrosine residue located in the intracellular domain of NL1 regulates the differential assembly of excitatory versus inhibitory synapses. Furthermore, in the absence of highly specific antibodies compatible with immunostaining of native adhesion molecules, little is known about the precise distribution of endogenous NL1 within the synapse. In this project we will #1) decipher the localization of endogenous NL1 and its modulation between excitatory and inhibitory synapses based on its phosphorylation state by using a new transgenic knock-in mouse line in which endogenous NL1 has been tagged with a small biotin acceptor peptide (BAP-NL1); #2) we will uncover how ASD-linked mutations in NL1 affect synaptic changes at the morphological and functional levels, in both physiological and ASD conditions. ExploNL1 will shed light on the basic molecular mechanisms regulating the differentiation of excitatory and inhibitory synapses, and as a consequence the underlying pathological basis of ASDs.

Keywords: adhesion molecules synapses light and electron microscopy autism spectrum disorders
Outwitting the enemy: do invasive snakes and local lizards engage in a cognitive arms race?” (INVASIVE_ARMS_RACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Cognition is often assumed to be beneficial, as it allows individuals to adjust to all kind of environmental challenges. However, which exact environmental challenges drive the evolution of animal cognition remains an open question. Predation is often raised as an important driver of cognitive evolution, because animals that can improve their antipredator behaviour through learning may survive better, especially in dangerous environments. How environmental predation risk influences prey cognition is, however, only scarcely studied, with conflicting results. Here, I plan to make use of an unique opportunity to investigate the role of predation in cognitive evolution. I will examine how changes in predation pressure, caused by an invasion of alien snakes into the island of Ibiza, affect the cognition of endemic lizards. I will test how predation risk affects cognitive variation among and within populations of prey, and specifically the trade-off between learning speed versus accuracy (i.e. cognitive style), an understudied aspect of cognition in this context. Another gap in our knowledge is how exactly cognitive abilities help individuals to avoid being predated, and hence as a second goal I will test whether individual's cognitive performance and style relate to their ability to recognize and respond to predators. Finally, one aspect that has rarely been taken into consideration in the past, is how the cognitive abilities of the predator itself affect prey cognition and vice versa. As a final goal, I will test the exciting unexplored hypothesis of a cognitive arms race between predator and prey. In addition, this project will also integrate neuroscience with cognitive ecology, and delve deeper into the genetic and neural mechanisms underlying cognitive changes in prey and predator.

Keywords: behavioural ecology,animal cognition,predation,predator prey arms race,invasive alien species,brain size evolution