Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nucleolar Responses to DNA Damage: rDNA, an emerging hub of genome instability (NUCDDR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Greece
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1499525.0
EU funding (EUR): 1499525.0
Participants: 1
Project status: CLOSED

DNA lesions can impose serious threats to genome integrity and cell viability. Whereas DNA damage may occur anywhere in the genome, it is increasingly recognized that certain genomic loci rich in repetitive sequences display increased susceptibility to damage and are linked to chromosomal rearrangements and malignancy. Clusters of ribosomal DNA gene (rDNA) repeats, present on five different chromosomes, constitute the most heavily transcribed area of the human genome and are organized in a nuclear membrane-less organelle, the nucleolus. So far, putative links between rDNA damage and malignant processes have not been rigorously assessed. We will address the hypothesis that rDNA repeats represent a major hub of genomic instability contributing to malignant transformation. Using state-of-the-art experimental systems that allow enrichment for nucleolar DNA damage, we will explore: (i) hypothesis-driven and mass spectrometry-based approaches to define regulators of the rDNA damage response; (ii) live imaging and advanced molecular biology tools to uncover how histone epigenetic changes and formation of RNA:DNA hybrids impact on nucleolar chromatin, nucleolar organization, rDNA transcription and repair ; (iii) cell models that recapitulate malignant transformation caused by inducible oncogene expression or epigenetic inactivation of tumour suppressors, to assess replication stress in rDNA repeats as a primary source of genomic instability and pertinent to hallmarks of cancer. The proposed research is expected to yield novel insights into the signaling networks and biological processes regulating rDNA damage and repair within the nuclear environment and define how these mechanisms are corrupted during neoplastic transformation. This knowledge could be directly applicable to the design of new diagnostic or therapeutic strategies for cancer.

Keywords: dna damage response,nucleolus,hippo pathway,genome stability,epigenetics,rassf1a
From Copernicus Big Data to Extreme Earth Analytics (ExtremeEarth)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Norway,Sweden,Norway,Greece,Greece,United Kingdom,United Kingdom
Call: Big Data technologies and extreme-scale analytics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 5988301.25
EU funding (EUR): 5988301.25
Participants: 11
Project status: CLOSED

Copernicus is the European program for monitoring the Earth. The geospatial data produced by the Sentinel satellites puts Copernicus at the forefront of the Big Data paradigm, giving rise to all the relevant challenges: volume, velocity, variety, veracity and value. ExtremeEarth concentrates on developing the technologies that will make Europe a pioneer in the area of Extreme Earth Analytics i.e., the Remote Sensing and Artificial Intelligence techniques that are needed for extracting information and knowledge out of the petabytes of Copernicus data. The ExtremeEarth consortium consists of Remote Sensing and Artificial Intelligence researchers and technologists with outstanding scientific track records and relevant commercial expertise. The research and innovation activities undertaken in ExtremeEarth will significantly advance the frontiers in Big Data, Earth Analytics and Deep Learning for Copernicus data and Linked Geospatial Data, and make Europe the top player internationally in these areas. The ExtremeEarth technologies will be demonstrated in two use cases with societal, environmental and financial value: the Food Security use case and the Polar use case. ExtremeEarth will bring together the Food Security and Polar communities, and will work with them to develop technologies that can be used by these communities in the respective application areas. The results of ExtremeEarth will be exploited commercially by the industrial partners of the consortium.

Keywords: copernicus program,earth observation data,scalability,linked geospatial data,extreme earth analytics
New Approaches to the Identification of Macroeconomic Models (Macro Identification)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1312383.0
EU funding (EUR): 1312383.0
Participants: 1
Project status: CLOSED

Macroeconomic data are largely non-experimental. Thus, causal inference in macroeconomics is largely based on assumptions about what aspects of the variation in the data are exogenous. This presents two major challenges, which this research addresses directly. First, few such assumptions are generally accepted. Second, conditional on any set of assumptions, identification of causal effects is often weak because there is little relevant variation in the data. To tackle these challenges, I propose three lines of enquiry to explore new sources of identification and develop the requisite econometric methods. The first line will study the implications of the so-called ‘zero lower bound’ (ZLB) on nominal interest rates for identification. The key novel insight is that the ZLB causes monetary policy to be set at least in part exogenously. This can be thought of as a natural experiment that generates a new instrument to identify the underlying policy model. This insight applies more generally to policy functions subject to exogenous constraints. The informativeness of these constraints depends on the probability that they bind, so recent experience makes the ZLB a promising application of the idea. The second line will analyse new ways of using time-variation in some of the parameters of macroeconomic models, such as trend inflation or the volatility of shocks, to study important open questions in macro, such as the degree of forward versus backward-looking behaviour and the ‘good luck versus good policy’ debate. The third line will contribute to the on-going research on developing methods of inference that are robust to weak identification. This is a pervasive problem in macro that threatens the validity of structural inference under any identification scheme. The synergies among these three lines' methodological analyses will accelerate progress on each line well beyond what would be possible in a piecemeal approach.

Keywords: econometric theory,instrumental variable methods,weak instruments
Passive Actuated ventiLation Opening systeM for Aircraft (PALOMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France,France
Call: Passive Actuated Inlet for UHBR engine ventilation (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-10-31
Duration (months): 34.0
Total project cost (EUR): 1098663.75
EU funding (EUR): 769064.63
Participants: 5
Project status: SIGNED

PALOMA will design and test a passively actuated opening system that will allow a volume of secondary air flow to be diverted into the engine core area for cooling purposes. Being entirely passive, no external electrical, hydraulic or pneumatic power will be required to run or control the system. The system will use a heat pipe to transfer the necessary heat to a shaped memory alloy (SMA) component whose movement will, through a set of mechanical linkages, open a flap set within the nacelle inner walls. This system will permit an optimisation of the engine thermal management and performance whilst needing minimal maintenance. Based on an agreed set of requirements, the project partners will first perform a trade-off in terms of possible heat pipe and SMA material and geometric forms, followed by their full characterisation. This information will permit a) the design of the system to be performed after a trade-off considering the constraints (positioning, extreme temperatures and aircraft accelerations) linked to the installation of such a system in a nacelle b) the modelling of the system’s behaviour. Having completed the design, a functional prototype will be tested on a specifically design test bench to simulate operation conditions including pressure, temperature and vibration according to the requirements of the DO160, mandatory for all equipment used on aircraft. The results of the tests performed on the functional prototype will be integrated into the design of a demonstrator (which may also be used for flight tests) which in turn will be manufactured and tested. Modelling activities will support the project throughout its execution. The PALOMA solution will be fully European and brings together: a thermal management engineering and modelling company, a heat pipe specialist, an SMA specialist with unique design and industrial manufacturing capabilities and a broad-spectrum engineering company specialised in aircraft and engine integration.

Keywords: engine cooling,ventilation system,uhbr,passive actuator,shaped memory alloy,heat pipes,modelling,nacelle integration,prototype,demonstrator
Colloidal Iron Oxide Nanoparticles for the REclamation of Toxic Metal Contaminated GROUNDwater Aquifers, Drinking Water Wells, and River Bank Filtrations (REGROUND)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Germany,Belgium,Portugal
Call: First application and market replication (H2020-WATER-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2018-12-31
Duration (months): 40.0
Total project cost (EUR): 2868093.58
EU funding (EUR): 2734222.5
Participants: 8
Project status: CLOSED

The main objective of the presented innovation action is the first application and near-market replication of a novel water nanogeotechnology for the immobilization of toxic metals in groundwater aquifers, drinking water wells, and river bank filtration sites. The basic concept of our technology is the creation of an adsorptive in situ barrier for the immobilization of toxic metal contaminations. This barrier is made of iron oxide nanoparticles, which are injected into sediments as colloidal suspension, forming stable deposits there. Over the last 6 years, we have developed a novel technology for the injection of iron oxide nanoparticles (NPs) into groundwater contaminant plumes. The feasibility of this approach has been successfully tested in lab experiments and a scientific field application. Specifically, our approach addresses arsenic, barium, cadmium, chromium, copper, lead, mercury, and zinc, all of which are known major groundwater contaminants. Now, we want to bring this novel, green and near-market water eco-innovation into the European markets, and beyond. The very core of this effort is the performance of two industrial-scale applications of our technology at two different types of contaminated sites. This first application of our technological approach under field conditions is the major objective of REGROUND. By developing our technology into a market-ready application, REGROUND will globally transform the efforts to mitigate the risks posed by toxic metal contaminations to humans and ecosystems. The REGROUND technology, due to its low costs and wide applicability, will be made highly available. The near-market replication of our technology and subsequent commercialization efforts are an integral part of REGROUND. This will enable immobilization of toxic metal contaminations at sites which were left untreated so far due to technical or economic reasons.

Keywords: groundwater remediation,heavy metal immobilization,drinking water well protection
Low Cost Materials Processing Technologies for Mass Production of Lightweight Vehicles (LoCoMaTech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Spain,Greece,Hungary,Sweden,Romania,France,France,Czechia,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Affordable weight reduction of high-volume vehicles and components taking into account the entire life-cycle (H2020-NMBP-GV-2016, 2016)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 7997725.0
EU funding (EUR): 7997725.0
Participants: 21
Project status: CLOSED

The overall aim of LoCoMaTech is, in the first place, to enable the novel HFQ® process, (patented by ICL) in its latest most advanced form, which includes 10 recently patented refining technologies (TRL4), to be used for the manufacture of lightweight, high strength body and chassis structures and components for low-cost vehicles, by establishing a prototype, full scale pilot production line (TRL6), supported by a supply chain ranging from raw material to end of life. This will be the first low-cost technology in the world enabling manufacture of high-strength lightweight complex-shaped aluminium parts and low environmental impact. The 1st generation of HFQ technology has already been commercially used in manufacturing 4 types of niche vehicles. This project aims at bringing the materials and manufacturing cost significantly down, through introducing newly patented technological measures, by which the technology could be used for producing low-cost vehicles. The low-cost HFQ® technology will be used first for mass production of aluminium car body and chassis structures (eventually for all vehicles), which will lead to substantial improvement in energy efficiency, performance and travel range of low-end vehicles. LoCoMaTech will construct a world first low-cost HFQ® aluminium production line (prototype), targeting reduction of energy consumption per vehicle by 15.3-22%, and cost-effective weight savings from 8.55 to 2.16 €/kg-saved and improvement of LCA environmental impact by 15.39-26.8%. LoCoMaTech plans to assist in creating 53 commercial production lines and 1700 jobs, in year 6 from the completion of the project. The potential market for low-cost HFQ® technology for passenger cars alone is over €160 billion pa, and double this, if buses, trucks, trains and aircraft are considered. This will create huge wealth for Europe and place European automotive industry in a world leading position for lightweight manufacturing technologies for low-end vehicle production.

Keywords: low cost vehicles,mass production,lightweight body and chassis structures,high strength aluminium,low cost hfq aluminium technologies,materials processing,multi objectives optimization
INnovation CApacity of Mediterranean Enterpises (INCAME_2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 296303.75
EU funding (EUR): 296302.0
Participants: 14
Project status: CLOSED

The project aims to enhance SMEs’ competitiveness and innovation processes management and to improve the regional innovation environment, increasing the efficiency and the effectiveness of investments in research, development and innovation. The project partners will operate in the regions under the EEN BRIDGeconomies consortium: Abruzzo, Basilicata, Calabria, Campania, Molise, Puglia and Sicilia. The overall objective of the project is helping SMEs to adopt, implement and deploy an innovation management system. The project has two main specific objectives, structured in 2 Work Packages: WP1) SMEs beneficiaries of the SME Instrument, Fast Track to Innovation, Future and Emerging Technologies Open (Key Account Manager) ; WP2) SMEs with innovation potential (EEN Innovation Expert) EIMC. To reach such specific objectives, during the period covered by the action, the project partnership intends to deliver seven / ten days service packages to a number of 123 SMEs, benefiting from SME Instrument grants and services for enhancing their innovation management capacities. Project partners intend to implement these actions since SMEs play a crucial role in reaching the objectives of the Europe 2020 Strategy and notably the Innovation Union. SMEs are key drivers of innovation serving as an important conduit for knowledge spill-overs. Tapping the full innovation potential of SMEs requires efficient support mechanisms. The focus needs to be oriented to impact on SMEs, looking at their internationalisation, their knowledge and R&D capabilities, competitiveness and growth.

Keywords: innovation management,enhancing,smes capacities in southern italy
Novel binder-ionomer-free electrodes enable ultra-low Pt loading electrodes for low cost High Temperature proton exchange membrane fuel cells based in phosphoric acid-doped polybenzimidazole membranes (LOWCOST-PBI-HTPEMFC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-15
End date: 2020-08-14
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

In spite of the promising prospects as future green energy conversion device, low temperature-proton exchange membrane fuel cells (LT-PEMFCs) based in perfluorosulfonic acid membrane have achieved a penetration in the energy market rather low, being cost and durability the main barriers to the worldwide commercialization. As an alternative, high temperature- (HT-) PEMFCs based in phosphoric acid-doped polybenzimidazole membranes are gaining much of attention due to the benefits over the LT-PEMFCs (e.g. no need of auxiliary humidification system, much higher CO and sulfur tolerance, very suitable for cogeneration in combined heat and power systems, easier thermal management, etc.). However, the main drawback is the high Pt content of the electrodes that, according to the state-of-the-art, is greater than 0.5 mgPt cm-2 (2-5 times higher than LT-PEMFCs state-of-the-art). This project aims to develop a novel configuration of the HT-PEMFC electrode that enable the achievement of low cost ultra-low Pt loading electrodes (≤ 0.1 mgPt cm-2) with competitive power output and durability. A paradigm shift is proposed in the structure and composiition of the catalytic layer of the HT-PEMFC electrode as no ionomer or binder is incorporated, only the catalyst and the electrolyte (phosphoric acid) are present. The absence of Pt site-blockers, as the binder or the ionomer polymers, significantly enhance the electrochemical surface area at ultra-low Pt loadings enabling a reasonable performace output. Results of this project have a strong potential to be transferred to the electrode production in the emerging industry of HT-PEMFCs. The project involves a number of analytic techniques and specific equipment that ensures the transfer of knowledge and the training to the experienced researcher while the candidate will bring his expertise in LT-PEMFCs as a positive feedback to the HT-PEMFCs research field.

Keywords: high temperature pemfc,pbi based pemfc,phosphoric acid doped pbi based ht pemfc pemfc,ultra low pt loading electrodes
Determining multi-level led causes and testing intervention designs to reduce radicalisation, extremism and political violence in north-western Europe through social inclusion (DRIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Norway,Sweden,Sweden,Norway,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Addressing radicalization through social inclusion (H2020-SC6-GOVERNANCE-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2999921.25
EU funding (EUR): 2999921.25
Participants: 9
Project status: SIGNED

In recent years, research on extremist identity politics and political violence in Europe has focused on patterns of violent radical Islamism and far-right radicalisation among young men. This research has brought to the fore problems of identity, belonging, inter-generational change, alienation, marginalisation, inequality, masculinity and miseducation. These findings point to matters of space and place that compound existing exclusionary discourses based on ethnicity, religious identity, socio-economic status and politics. Moreover, far right movements and violent Islamists not only have similar breeding grounds but they arguably also feed off each other’s rhetoric and activism in particular local urban areas. However, there are significant gaps in understanding the interplay between these different forms of local extremism, as no study has yet to investigate the synergies or reciprocity between Islamist and radical right extremism in a comparative European context. Moreover, there is no detailed understanding of the relationship between the individual and structural factors that also take into consideration the psychosocial circumstances affecting already vulnerable people. There remains a fundamental lack of appreciation of the wider struggles of social inclusion that affect the radicalisation experience in urban areas. It is a central concern for all vulnerable people concerning radicalisation, where questions of personal and political identity combined with issues of intergenerational change affect the paths individuals can take. DRIVE will produce a range of policy-orientated research findings to better understand how exactly social inclusion impacts on radicalisation for far right and Islamist groups in different parts of North-Western Europe, the targeted groups and geographical focus of this project. The findings from this project will help to determine European-wide policy solutions that concentrate on social inclusion in de-radicalisation initiatives.

Keywords: ethnicity,extremism,reciprocal radicalisation,social conflict,public heath,deradicalisation