Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Process intensification towards sustainable wastewater treatment with phototropic biofilms (Inlight)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

Improving current biological wastewater treatment (WWT) plants towards more sustainable solutions is a priority of the EU (Water Framework Directive). Conventional activated sludge technology faces some challenges such as high O2 demand and inevitable CO2 emissions. Phototropic microorganisms offer a sustainable way of WWT by converting CO2 to O2 and valuable biofeedstock which can further be converted to bioenergy. Photogranules are compact spherical biofilms which contain high amounts of phototrophs in addition to heterotrophs. As a result, photogranule based WWT can couple CO2 and O2 fluxes from different microorganisms leading to an aeration free WWT. However, to utilize the true potential of this technology, revolutionary reactor designs together with more fundamental understanding on photogranulanation is needed. This work aims to intensify photobioreactors for WWT by using a multidisciplinary approach which combines microrhelogy and microbiology with mass and photon transport models. To have more control over growth and light, novel supports for biofilms will be designed. In addition, the project will explore the relationship between environmental conditions such as light availability and shear on microbial community composition and structure in complex phototropic biofilms by both microfluidic experiments and mathematical models. The information obtained from these studies will be translated to a macroscopic level using simplified transport phenomena models to design an efficient photobioreactor. The findings of this study will both advance our understanding of phototropic biofilms and pave the way towards industrial-scale sustainable WWT. With this project, I am aiming to combine my background on design and modelling of light-driven multiphase systems with the distinguished expertise of the host research group in WWT at TU Delft while acquiring further knowledge on mass transfer in photobiofilms during my secondment at ETH Zurich.

Keywords: process intensification,biofilms,phototropic microorganisms,photogranules,wastewater treatment
PALOMERA - Policy Alignment of Open access Monographs in the European Research Area (PALOMERA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Belgium,Netherlands,Finland,Poland,Germany,France,United Kingdom,Portugal,Slovenia
Call: Supporting the development of aligned policies for open access books and monographs (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 1859812.5
EU funding (EUR): 1859812.5
Participants: 16
Project status: CLOSED

Academic books continue to play an important role in scholarly production and research communication, particularly in the social sciences and humanities. As an important output of scholarly production, academic books must be included in open science/open access policies and strategies developed by research funders and institutions, to ensure that open science becomes the modus operandi of modern science across all disciplines. However, contrary to article publishing in journals (especially in the areas of Science, Technology, and Medicine) academic books have not been a focus point for open access (OA) policymakers. Consequently books are only rarely mandated to be published OA by research funders and institutions. PALOMERA will investigate the reasons for this situation across geographies, languages, economies, and disciplines within the European Research Area (ERA). Through desk studies, surveys, in-depth interviews, and use cases, PALOMERA will collect, structure, analyse, and make available knowledge that can explain the challenges and bottlenecks that prevent OA to academic books. Based on this evidence PALOMERA will provide actionable recommendations and concrete resources to support and coordinate aligned funder and institutional policies for OA books, with the overall objective of speeding up the transition to open access for books to further promote open science. The recommendations will address all relevant stakeholders (research funders and institutions, researchers, publishers, infrastructure providers, libraries, and national policymakers). The PALOMERA consortium broadly represents all relevant stakeholders for OA academic books, but will facilitate co-creation and validation events throughout the project to ensure that the views and voices of all relevant stakeholders are represented, promoting diversity, equity, and inclusion.This will assure maximal consensus and take-up of the recommendations.

Keywords: open access,academic book publishing,scholarly communication,research funding,humanities and social sciences
Protecting the aquatic environment from urban runoff pollution (StopUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Norway,Italy,Switzerland,United Kingdom,Netherlands,Tunisia
Call: Preventing and managing diffuse pollution in urban water runoff (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3766439.75
EU funding (EUR): 3766439.5
Participants: 11
Project status: SIGNED

Major progress has been achieved in protecting European freshwaters through the successful implementation of urban wastewater treatment infrastructures but significant pressures still pose threats to the quality of the receiving water bodies. The recent evaluation of the Urban Wastewater Treatment Directive underlined that, in particular stormwater overflows including urban surface run-off and combined sewer overflows bring relevant pollutant loads into the aquatic environment. The pressure on water resources from those kinds of emissions is expected to aggravate through the impacts of global climate change with more frequent intense precipitation as well as more pronounced drought conditions. To address those challenges new ways in effectively mitigating pollution arising from urban run-off and sewer overflows are needed, providing effective load reduction, in a way affordable as well as acceptable to end-users and the society. The StopUP project will elucidate pollution pathways in urban catchments to enable targeted interventions through measures at source, retention and treatment. It will foster knowledge about emissions incl. pollutant release, transport and receiving water bodies through advanced monitoring concepts, online sensors and data processing and analysis. In the context of different case studies, innovative technologies for pollution prevention such as advanced retention soil filters for combined sewer overflow treatment which can be integrated better in urban areas will be further developed and tested. The tests will demonstrate integrated solutions including monitoring, treatment and control of diffusive pollution in different contexts concerning geographic, climatic and hydrological as well as socio-economic settings. Based on the findings, tools to support selection, implementation and operation of pollutant mitigation measures for end-users including environmental authorities, water boards/utilities, consultancies will be derived.

Keywords: urban runoff,online monitoring,water quality modelling,natur based solutions
Modelling Neanderthal landscapes during MIS4: Survival beyond the glacial period (NEANSCAPES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 2
Project status: SIGNED

The NEANSCAPES project aims to advance our understanding of Neanderthal subsistence strategies during MIS4 (71-57 ka), a glacial period that imposed harsh conditions that impacted on environment on a worldwide scale. The transition from the temperate phase of MIS5 (128-71 ka) to the cold phase of MIS4 required flexibility and innovation in livelihood strategies and resource management by these populations. Much is known about MIS5 and MIS3 (57-27 ka), but there is a notable gap in human subsistence during MIS4. This project will assess the impact of MIS4 on the resilience of Neanderthals in Iberia for understanding their ability to cope with severe climatic cycles. It will test whether this species behaviour was maintained invariably, making them vulnerable to abrupt climatic changes, or conversely, they were able to change their behaviour when the environmental changed drastically. To this end, the project will examine the ungulates hunted from archaeological sites in north-eastern Iberia, where repeated and intense Neanderthal occupations span the entire MIS4 glacial period, from the Pyrenees to the coast. Stable isotopes (oxygen, carbon, nitrogen, sulphur, strontium) preserved in the animal tissues recovered on sites provide detailed information on the animals' past ecology. By combining multi-isotope analysis with isoscapes modelling (oxygen, sulphur, strontium) on the region, we will provide a high-resolution climate and spatial reconstruction directly linked to human presence, to characterized past human habitat. Using isoscape modelling, NEANSCAPES will maximise the resolution provided by stable isotopes to characterise the micro-environments frequented by humans and to understand landscape use resulting from human population choices. This cross-cutting methodology has never been applied to Palaeolithic research in Iberia and will provide a good opportunity to test its suitability on a regional scale and to generate new analytical tools.

Keywords: neanderthals,middle palaeolithic,late pleistocene,mis4,human palaeoecology,stable isotopes,biochemistry,bioarchaeology,palaeoenvironment,faunal studies,vertebrates,isoscapes
Comprehensive Hazard Identification, and Monitoring systEm for uRban Areas (CHIMERA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Innovation actions
Countries involved: Poland,Sweden,Germany,Norway,Netherlands,Czechia,Japan
Call: Enhanced situational awareness and preparedness of first responders and improved capacities to minimise time-to-react in urban areas in the case of CBRN-E-related events (HORIZON-CL3-2022-DRS-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 5763943.75
EU funding (EUR): 4936447.75
Participants: 12
Project status: SIGNED

The CHIMERA project will provide a ground-breaking solution to the selected shortcomings and gaps in the CBRN security market. The project aims to do so by developing a multiplatform Command & Control CBRNe system for responders, dispatch and crisis centres providing an area of interest overview, asset management, and real-time data visualization, as well as by developing a multipurpose heterogeneous sensor node for CBRNe detection allowing for the integration of commercially available detection instruments. Furthermore, the project aims to implement a real-time dispersion modelling software for C&R agents to provide dispersion models and source estimations considering the 3D urban environment, and to integrate data fusion algorithms combining data from different sensors from chemical, radiological or biological layers to enable agent identification and false alarm reduction. Ultimately, the CHIMERA project will create a commercial-ready database combining C, B and RN substance/agent characteristics. With these solutions, the project’s outcomes will considerably enhance both the operational capabilities of the first response and crisis management teams and the safety of the on-site personnel. All project-developed components will function as individual units as well as part of the whole system. In addition, the CHIMERA system will feature an open design to enhance its interoperability and facilitate other existing systems integration. To illustrate the system’s potential for real-world application, it will be demonstrated before a live audience of stakeholders, industry representatives, and potential end-users in a realistic scenario.

Keywords: cbrn,situational awareness,sensor node,data fusion,false alarm reduction,heterogeneous sensor node
Boosting Bio-Innovation and Bio-Entrepreneurship by Establishing Excellence in Biomolecular Engineering and Synthetic Biology (Boost4Bio)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Greece
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

The Biomedical Sciences Research Center “Alexander Fleming” (FLEMING) is the top-ranked research center in the Life Sciences in Greece. FLEMING has gained international recognition for its pioneering research towards understanding the molecular basis of human diseases, such as autoimmune disorders, cancer, neurodegeneration and osteoporosis, and the development of new approaches for their diagnosis and treatment. The Centre’s major goal for the coming years is to support excellent research with a focus on innovation. In this direction, FLEMING has recently established the new Institute of Bio-Innovation with a mission to advance basic research discoveries towards innovation in the areas of biotechnology and drug discovery and convert them to tangible outcomes for the economy and the society. Furthermore, FLEMING has planned the establishment of the national R&I infrastructure “Biotechnopolis”, the first integrated Biotechnology hub in Greece and the wider region, to foster the development of innovative biomedical, biotechnological and pharmaceutical products and technologies through the creation of a fertile environment offering access to excellent research, high-end infrastructures and a culture of entrepreneurship close to academia. The goal of Boost4Bio is to attract and maintain an exceptional researcher and innovator in Biomolecular Engineering & Synthetic Biology to establish a new excellent team at FLEMING, promote the integration of basic and applied research, boost bio-innovation and bio-entrepreneurship at the Center, and lead the establishment of “Biotechnopolis”. Boost4Bio will have a major impact on the promotion of excellence in biomedical research, training and innovation in Greece, will support the proper establishment of a new and unique Excellence Unit in Greece and the wider region, and will contribute to the creation of new career prospects and the prevention of the brain drain phenomenon, which is particularly acute in this area of the Union.

Keywords: biotechnology,biomolecular engineering,synthetic biology,drug discovery and development,bio therapeutics bio innovation,bio entrepreneurship
MIGRants’ strAtegies in carinG for and receiving care from their Elderly parents: Designing paths at the intersection of border, care and labour regimes (MIGR-AGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada,Colombia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2029-06-30
Duration (months): 36.0
Total project cost (EUR): 341683.08
EU funding (EUR): 341683.08
Participants: 3
Project status: SIGNED

Analysts and institutions estimate that contemporary societies, especially in the Global North, face an entangled triple challenge: the ageing of the population, ensuring the sustainability of welfare state provisions, and migration. Meanwhile, anti-migration discourses have raised, resulting in migrants’ increasing external and internal bordering. In this context, older migrants, and especially economic migrants’ and refugees’ parents and grandparents, are suspected of excessively drawing on social welfare. Consequently, their entrance to and permanence in Global North countries and their access to care benefits and programs are being limited, leading to new forms of stratification in social reproduction. MIGR-AGE aims to understand how the intersection of care, border and labour regimes shapes the strategies of adult migrants to care for and receive care from their elderly parents. The project focuses on the experience of Colombian families in Italy and Canada, in which elderly parents are (or were until recently) living in Colombia. It combines policy analysis with in-depth interviews, participatory videos, and participatory restitution meetings that will be conducted in the country of emigration in the Global South, Colombia, and in the two countries of immigration in the Global North, Italy and Canada. The project adopts an innovative theoretical and methodological approach that crosses disciplines (sociology, anthropology, political economy, and political sciences) and levels of analysis (at the micro, meso, and macro levels). Moreover, it follows a multi-sited and decolonial perspective that does not only focus on Global North countries but crosses analysis in the Global North/South and emigration/immigration countries to better understand migration patterns and inequalities in social reproduction at the global level. By pursuing this objective, MIGR-AGE addresses several Sustainable Development Goals and is in line with the European Care Strategy.

Keywords: social reproduction,migration,ageing,care,social policies,globalisation,inequalities
RiboScreenTechnology delivers drugs for targeted engineering of ribosomes to restore dysregulated protein levels in rare and prevalent disease (RIBODRUG)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 700000.0
EU funding (EUR): 700000.0
Participants: 1
Project status: CLOSED

KBHB Consult GmbH is a privately owned biotechnology company headquartered at Salzburg, Austria. Founded in 2019 as a spin-out of the University of Salzburg, KBHB owns all intellectual property related to its proprietary RiboScreen™ Platform Technology (RSPT) and associated drug patents, with full freedom to operate (FTO). RSPT is a first in class deeptech platform, employing serial precission filters that deliver small molecules, which tailor ribosomal activity to restore, enhance, or attenuate protein production levels in disease, redefinig protein targeted therapeutics. The University of Salzburg and the State of Salzburg, through Innovation Salzburg GmbH, endorse KBHB’s role in the regional and European biotech ecosystem, appreciating the strategic contribution of RSPT to innovation. The company’s vision is to transform drug discovery by intervening at the origin of protein synthesis rather than modifying proteins post translationally. Proof of concept was achieved by restoring in a rare skin disease, skin anchor protein Lamb3 expression with repurposed Artesunate, reaching TRL 6 and demostrating clinical feasibility. With EIC Accelerator support, KBHB aims to extend this platform across oncology and neurodegenerative (NDD) and rare diseases, thus maintainig benefit to the underserved rare disease community. The pipeline includes (1) Artesunate derivatives for rare diseases, (2) small molecules restoring full lenght p53 in oncology, and (3) projects fully set up, to deliver molecules that boost Parkin in Parkinson´s disease. A moderate, but targeted, EIC funding request of EUR 700,000 (with EUR 300,000 co-investment by KBHB) will enable the recruitmet of young scientists and the transition of RSPT from valdiated proof of concept to market readiness, first licensing agreements and industry partnership. This targeted investment will bridge the gap to clinical translation and position Europe as a leader in precsission based drug discovery.

Keywords: riboscreen platform technology,novel drug targets,ribosomal proteins,oncology,ndd,rare disease