Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Differential DOM-cycling through Microbes and Sponges (DDMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-15
End date: 2023-08-14
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: SIGNED

Anthropogenic disturbances, such as nutrient pollution and overfishing, threaten coral reefs by facilitating community shifts from reef-building corals to algae, increasing production of algal-derived dissolved organic matter (DOM). DOM is the largest food source on reefs, but cannot be consumed by most reef animals. Instead, microbes and sponges transform DOM into particles that re-enter the food web. These recycling pathways, termed the “microbial and sponge loops”, are understood as crucial ecosystem adaptations for reefs to thrive as biological hotspots under nutrient-poor conditions. However, the increased load of algal-DOM on degraded reefs has been associated with the inefficient growth of pathogenic microbes—the “microbialization of reefs”. Sponges have been hypothesized to further stimulate this microbialization by feeding on increased algal-DOM and accelerating algal proliferation via the subsequent release of nutrients. Through this “vicious circle”, microbes and sponges may jointly promote the degradation of coral reefs even faster than the usual, and much more studied, suspects of climate change (i.e., rising seawater temperature and ocean acidification). I aim to determine whether planktonic microbes and sponges compete over DOM (i.e., feed on same or different DOM components) under past, present, and future projections of available DOM. Thereto, I will characterize the composition of different DOM types (e.g., coral- and algal-DOM) and mixtures of DOM representing past, present and future DOM-producing communities and assess their availability (uptake) and utilization (metabolic processing) by planktonic microbes and sponges. I will further assess the ability of planktonic microbes to utilize sponge-processed water and vice versa. With this project I will lay the foundation to integrate microbes and sponges as understudied key ecosystem engineers into coral reef food web frameworks that will allow to elucidate the fate of future coral reefs.

Keywords: dissolved organic matter,sponges,microbes,corals,algae,coral reef,nutrient cycling
Induced pluripotent stem cell seeded active osteochondral nanofibrous scaffolds (iP-OSTEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Austria,Germany,Germany,Hungary,Poland,Norway,Czechia,Netherlands,United Kingdom,Denmark,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1099400.0
EU funding (EUR): 1099400.0
Participants: 14
Project status: SIGNED

iP-OSTEO project focuses on development of novel cell-based scaffolds for bone and cartilage repair in patients with poor regenerative capacity. We are proposing technology combining iPSCs with improved regeneration capacity combined with nanostructured scaffolds based on electrospun scaffolds and drug delivery system stimulating cell regeneration based on electrosprayed and spray-dried particles. The system will deliver novel treatment method for older patients, for which the current cellular and cell-free methods are ineffective. iP-OSTEO will reach its goals by creating an international and interdisciplinary training program. 7 companies (SMEs) and 7 academic institutions across European Union will join there forces though dedicated secondments. The activities will involve networking, research/training, workshop and dissemination secondments. The project has in total 239 secondments involving exchange of Early-stage and Experienced researchers. The consortium is bonded by Dr. Eva Filova – young scientist with experience in bone and cartilage tissue engineering. The iP-OSTEO project will help in better integration of academic and industrial stakeholders across Europe and help diseased people by providing novel therapeutic methods. Nevertheless, project has 169 ESR secondment months leading to training of new generation of scientists with international connection and knowledge of intrasectorial enviroment.

Keywords: ipscs,scaffolding system,osteoporosis,osteoarthritis,ageing,musculoskeletal disease,3d cell culture,bioreactors,personalized medicine,drug delivery,controlled release,nanofibers
FOSTERING SOCIALLY INNOVATIVE AND INCLUSIVE STRATEGIES FOR EMPOWERING CITIZENS IN THE RENEWABLE ENERGY MARKET OF THE FUTURE (SocialRES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Ireland,Germany,Germany,Romania,Croatia,France,United Kingdom,Portugal
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2018-NZE-CC, 2018)
Start date: 2019-05-01
End date: 2022-12-31
Duration (months): 44.0
Total project cost (EUR): 2444198.75
EU funding (EUR): 2444198.75
Participants: 13
Project status: CLOSED

Realising an accelerated expansion of renewable energy will require a switch from centralised to decentralised energy production and greater social participation, together known as energy democracy. The increase in energy democracy and social equity will be an essential part of the clean energy transition. A transition that could represent one of the most fundamental social, economic and technical changes in modern history. The most common businesses associated with social innovation in the renewable energy sector are Cooperatives, Aggregators and Crowdfunding platforms. These businesses facilitate consumers to take a more active role in the electricity system. Achieving sustained growth in energy democracy requires a better understanding of support structures for successful social innovation across technical, legal and economic systems. SocialRES aims to devise more effective ways of increasing social innovation leading to greater social acceptability as well as more durable governance arrangements and socioeconomic benefits. Through research excellence and co-creation of knowledge with relevant stakeholders, SocialRES will develop socially innovative and inclusive strategies for the energy system of the future. SocialRES will supplement the existing fragmented data on social innovations with new understandings from businesses, end-users and stakeholders to provide a comprehensive evidence base for policy design. The project will employ innovative techniques such as a Peer to Peer (P2P) crowd-investing for renewable energy sources (RES) projects, P2P lending and P2P virtual RES energy aggregator platform. The SocialRES team combines partners from a range of disciplines together with industry expertise to develop a comprehensive understanding of the strengths and limitations of the current renewable energy system to foster social innovation and to shape a roadmap for a future, more innovative and equitable system.

Keywords: renewable energy,cooperative,crowdfunding,aggregator,social sciences,business models
Novel biocontrol agents for insect pests from neuroendocrinology (nEUROSTRESSPEP)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Germany,South Africa,Germany,Israel,Belgium,Belgium,Sweden,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Native and alien pests in agriculture and forestry (H2020-SFS-2014-2, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 6995053.75
EU funding (EUR): 6995052.5
Participants: 14
Project status: CLOSED

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress. We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally. We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by: • utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management. • bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools. • validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Keywords: insects,insect pests,neuropeptides,peptide analogues,functional genomics,genetics,insect synthetic biology,genetic pest management,plant protection,environmental sustainability
Elucidating Dendritic Cell Heterogeneity and Functions in Metabolic Associated Fatty Liver Disease (MAFLDCs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

The increasing clinical and societal burden of metabolic-associated fatty liver disease (MAFLD) coupled with the current lack of therapies highlights the need for a better understanding of the mechanisms driving this disease. In recent years, studies, including my own, have identified that MAFLD is accompanied by a change in the T cell subsets present in the liver and blood. However, the functions and causes of these altered populations remain largely unknown. Conventional dendritic cells (cDCs) function to sample antigens in the periphery and subsequently migrate to the lymph nodes (LNs) where they induce the proliferation and polarisation of naïve T cells, which then home back to the periphery to perform their functions. As such, by manipulating cDC function, we could potentially alter the T cells present in MAFLD and hence improve disease outcome. To date, studies of cDC function in MAFLD have been hampered by our limited understanding of cDC heterogeneity and the lack of specific tools with which to manipulate them in vivo. Building on the cDC expertise of the host lab, the single cell technologies established to dissect heterogeneity, and access to more specific models to target these cells, here, I aim to dissect cDC heterogeneity in the fatty liver. To this end, I will combine the mouse models of the host lab, with my expertise working with human material to identify the conserved features across humans and mice. As MAFLD is associated with an increase in CD8+ T cells, I hypothesize that by manipulating the main cDC subset associated with cross-presentation of antigen to naïve CD8+ T cells, namely the cDC1s, I can manipulate disease progression. Using the novel XCR1-CRE mouse model to specifically target cDC1s in vivo, I will investigate the in vivo functions of these cells in MAFLD and determine their potential for therapeutic intervention to improve patient outcome.

Keywords: liver,obesity,mafld,dendritic cells,cite seq
Constraining LAnd Responses by Integrating ObservatioNs (CLARION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Climate-carbon feedbacks are a key unknown when projecting future climate change. Large ranges of feedbacks have been identified within the climate models used to make climate projections. Therefore, to make reliable and believable climate projections, there is an urgent need to reduce this uncertainty. In CLARION, I will focus on land-surface models (LSMs), the terrestrial component of climate models. I will investigate how observationally-constrained probability density functions (PDFs) of key model parameters (generated via Data Assimilation - DA) can be used to reduce the range of possible future climate-carbon cycle feedbacks. This will be done in three key steps using the UK JULES (Joint UK Land Environment Simulator) LSM, though, critically, the methods developed throughout this project will be applicable to any LSM. First, I will identify the key climate model parameters controlling the carbon, water, and energy cycles, and their relationship with future carbon climate projections. This will be done through sensitivity analysis experiments based on multi-ensemble runs. Second, using sophisticated Bayesian techniques and the extensive amount of in situ and Earth Observations available, I will calibrate these parameters to create observationally-constrained PDFs. Finally, these PDFs will be used to constrain the range of climate-carbon cycle projections by propagating the reduction in parameter uncertainty. This project will build on my strong expertise in DA techniques and will complement the Host Institute's cutting-edge emergent constraint work, which considers narrowing the range of climate feedback across models. This project will be a unique opportunity to take my demonstrable technical know-how and apply it to the climate change problem, generating high-impact results. During CLARION, I will also launch a JULES DA working group which will bring together the different UK expertise, encouraging collaborations throughout the project and beyond.

Keywords: climate change,data assimilation,earth observations,reducing uncertainty,land surface model
Genesis of Ethnicities and Nations in Textual Evidence for Scandinavia, c. 750-c. 1000 (GENTES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Traditional narratives of Scandinavian history generally see the early Middle Ages, or ‘Viking Age’, as the period in which the three kingdoms of Norway, Denmark and Sweden were created (or ‘unified’). Such narratives draw mainly on the 13th-century Icelandic Sagas, written several centuries after the events they portray. This project will challenge these narratives by developing and testing two hypotheses: 1) that contemporary and near-contemporary sources, rather than the sagas, should provide the basis of Scandinavian history between c. 750 and c. 1000; 2) that Scandinavia should be examined as a unit in this period, and that later borders and ethnic identities should not be projected into the past. To do so will require a critical re-evaluation of the written sources for the period. The objectives of the project will thus be to investigate five key areas: 1) bias and sources of information in contemporary and near-contemporary written sources; 2) the assessment of the sources, methods and agendas of twelfth-century Scandinavian texts; 3) the dating and transmission of Old Norse verse; 4) the reliability of the Icelandic Sagas; 5) the harmony of the resulting picture with archaeological evidence. These objectives will be achieved through an interdisciplinary, critical approach to the sources that will draw on historical, literary, philological and text-critical techniques. The sources will be studied in a European context, rather than a national or exclusively Scandinavian one. By drawing on the debate about ‘ethnogenesis’ that has transformed our understanding of Continental European history in the Migration Age, the project will present Scandinavia’s earliest history through a non-national lens. The resulting research will contribute to both scholarly and popular debates about historical identities and their (mis)use by nationalisms, which will be extremely timely, given the intensification of these debates in the wake of the refugee crisis and Brexit.

Keywords: scandinavia,early medieval,viking age,ethnogenesis,historical identities
Pressured to Attack: How Carrying-Capacity Stress Creates and Shapes Intergroup Conflict (ATTACK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2490382.5
EU funding (EUR): 2490382.5
Participants: 1
Project status: SIGNED

Throughout history, what has been causing tremendous suffering is groups of people fighting each other. While behavioral science research has advanced our understanding of such intergroup conflict, it has exclusively focused on micro-level processes within and between groups at conflict. Disciplines that employ a more historical perspective like climate studies or political geography report that macro-level pressures due to changes in climate or economic scarcity can go along with social unrest and wars. How do these macro-level pressures relate to micro-level processes? Do they both occur independently, or do macro-level pressures trigger micro-level processes that cause intergroup conflict? And if so, which micro-level processes are triggered, and how? With unavoidable signs of climate change and increasing resource scarcities, answers to these questions are urgently needed. Here I propose carrying-capacity stress (CCS) as the missing link between macro-level pressures and micro-level processes. A group experiences CCS when its resources do not suffice to maintain its functionality. CCS is a function of macro-level pressures and creates intergroup conflict because it impacts micro-level motivation to contribute to one’s group’s fighting capacity and shapes the coordination of individual contributions to out-group aggression through emergent norms, communication and leadership. To test these propositions I develop a parametric model of CCS that is amenable to measurement and experimentation, and use techniques used in my work on conflict and cooperation: Meta-analyses and time-series analysis of macro-level historical data; experiments on intergroup conflict; and measurement of neuro-hormonal correlates of cooperation and conflict. In combination, this project provides novel multi-level conflict theory that integrates macro-level discoveries in climate research and political geography with micro-level processes uncovered in the biobehavioral sciences

Keywords: experimental games,intergroup conflict,group dynamics,psychophysiology
INTEGRATED MODEL GUIDED PROCESS OPTIMIZATION OF STEAM CRACKING FURNACES (IMPROOF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Belgium,France,France,France,France,Netherlands,Netherlands,Luxembourg
Call: Industrial furnace design addressing energy efficiency in new and existing furnaces (H2020-SPIRE-2016, 2016)
Start date: 2016-09-01
End date: 2020-11-30
Duration (months): 51.0
Total project cost (EUR): 6878401.25
EU funding (EUR): 6878401.25
Participants: 13
Project status: CLOSED

The objective of the project IMPROOF is to drastically improve the energy efficiency of steam cracking furnaces by at least 20%, in a cost effective way, while simultaneously reducing emissions of greenhouse gasses and NOx per ton ethylene produced by at least 25%. One important way to reduce the energy input in steam cracking furnaces is to reduce coke formation on the reactor wall. The use of either advanced coil materials, combined with 3D reactor designs, improved process control, and more uniform heat transfer will increase run lengths, reducing simultaneously CO2 emissions and the lifetime of the furnaces. Biogas and bio-oil will be used as alternative fuels because they are considered renewable, and hence, decrease net CO2 production. Application of high emissivity coatings on the external surface of the radiant coils will further substantially improve the energy consumption. Less firing is required to reach the same process temperatures in the radiant coils. This will reduce fuel gas consumption and CO2 emissions by 10 to 15%. IMPROOF will demonstrate the advantage of combining all these technological innovations with an anticipated increase of the time on stream with a factor 3. To select the correct technologies for sustainable implementation in complex plant-wide and industrial data-intensive process systems, all the technology will be implanted in real-plant conditions at TRL6 in DOW. The strongly industrial oriented consortium is composed of 7 industrial partners, including 2 SME completed by 2 RTO and 2 university. This partnership shows a clear and strong path to the industrial and economical world with the involvement of all actors of the furnaces business. The financial resources mobilized by the partners represent a total grant of 6 878 401,25 € with a global effort of 538 person.month.

Keywords: steam cracking furnace,light olefin production,high emissivity material,3d reactor designs,renewable fuels,high performance computing,model based optimization