Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ACTION TOWARDS LABORATORIES ENHANCEMENT AND KNOW-HOW EXCHANGE FOR ADVANCED RESEARCH ON GEOSYSTEM (ATLAB)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-REGPOT-2011-1, 2011)
Start date: 2011-10-01
End date: 2015-03-31
Duration (months): 42.0
Total project cost (EUR): 3863851.6
EU funding (EUR): 3451423.0
Participants: 1
Project status: CLOSED

The ATLAB Centre is a multi-profile research unit, integral part of the Institute of Geological Sciences of the Polish Academy of Sciences, specializing in the development and application of isotope geochemistry as a major tool for innovative investigations that link modern geology, terrestrial environment and technology. Despite quite substantial funds allocated in the last years to the ATLAB Centre, the organizational and scientific level comparable to that of leading research institutions of the ERA has not been attained yet, first of all due to scarcity of funds, lack of adequate staff trainings and insufficient collaboration with external partners of scientific and industrial sector. The key idea of the proposed ATLAB project is to enhance significantly the research potential of the ATLAB Centre by upgrading the laboratories, hiring new specialists, and strengthening the know-how exchange for the development of advanced and innovative research on terrestrial geosystems. The main objectives of this ATLAB project are: (i) enhancement of the human capacity, (ii) improvement of the existing technical capabilities, (iii) development of strong multilateral collaboration with external partners of private and public sector, (iv) strengthening the partnership with European scientists, and (v) better integration with the ERA. The priority research fields of the ATLAB Centre as well as its overall development strategy are clearly defined in the project and particularly aimed at enlarging our knowledge of the surrounding environment, serving society and contributing to technological innovations. The ATLAB project will help to secure the development policy of the ATLAB Centre, directed on the collaboration with external partners for lasting mutual benefits, on the knowledge transfer and competitive future in cutting-edge scientific activities. The project will help to achieve sustainable development of the ATLAB Centre research quality, competitiveness and attractiveness.

Keywords: isotope geochemistry,environment,innovation,technical application,geosystem modeling,climate change
Dopaminergic Neurons for Cell Therapy in Parkinson's Disease (DOPANEW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,Germany
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 728596.0
EU funding (EUR): 728596.0
Participants: 2
Project status: CLOSED

Replacement of lost dopaminergic neurons by neural transplantation with embryonic nigral tissue is a most promising approach to the treatment of Parkinson’s disease. However, the limited availability of human embryonic dopaminergic neurons makes the search for alternative sources of transplantable neurons a priority. Based on an existing collaboration, a French academic research group with expertise in neurobiology and brain disease and a German company specialized in cell isolation and molecular gene analyses united to investigate the regulation of dopaminergic diffentiation and to develop new tools for the purification of dopaminergic neurons. We will analyze the molecular regulation of neuronal, in particular dopaminergic, diffentiation of new neurons that are permanently generated in the adult mammalian brain. To do so we will use sophisticated cell isolation strategies in concert with analysis of minute amounts of nucleic acids to observe changes in gene, transcript and protein expression in time and space. We will functionally test identified factors using in vivo assays and generate new tools for the isolation of neuronal subpopulations We will improve already known and develop new approaches that allow the efficient and reliable purification of dopaminergic neurons at different points of maturation from cultured stem cells. Furthermore, we will use known and identify new surface markers of neural progenitor cells and pluripotent cells to generate positive and negative cell sorting methods that will lead to transplantable cells in the absence of contaminating pluripotent and proliferative cell types. We will demonstrate the efficiency of these positive and negative selection approaches via transplantation experiments in vivo.

Keywords: neurobiology,brain research,cell biology
Strengthening University of Nova Gorica Research Potential in Environmental Sciences and Novel Nanomaterials (SUNGREEN)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Slovenia
Call:  (FP7-REGPOT-2011-1, 2011)
Start date: 2011-10-01
End date: 2016-01-31
Duration (months): 52.0
Total project cost (EUR): 4350753.6
EU funding (EUR): 3879420.0
Participants: 1
Project status: CLOSED

The SUNGREEN project seeks to reinforce the University of Nova Gorica, strengthening its innovative approach for research and development of new knowledge in environmental science and novel nano-structured materials. The reinforcement will be realized through establishment of strategic partnerships with top European R&D centres, recruitment of experienced researchers, acquisition of state-of-the-art research infrastructure, enhancement of UNG visibility and its collaboration with different stakeholders in the region. Through the implementation of the project, UNG will reach its full potential for research and technological innovation and will become one of the leading European research centres in the field environmental sciences and nano-materials. Excellent environmental science reputation of UNG is the result of integration of physics, chemistry, biology material science and computational science disciplines. Main objective of the project is strengthening of the research potential of UNG that needs new knowledge and research equipment. Project will enhance the capacity of UNG to successfully participate in research activities at EU level. The objective will be achieved through networking with other European world class research players, upgrading of relevant RTD infrastructure, recruitment of experienced researchers as well as through dynamic contribution to the regional and European sustainable socio-economic development through networking and dissemination activities. Project will pave paths for industrial uptake of new environmental technologies and will contribute to knowledge based economy and last but not least to cleaner environment. Transfer of know how will enable industries in the region at European level to produce innovative new products with high added value. Through project implementation, UNG will establish partnerships that will enable economically sustainable research both alone and in collaboration with network of partnering organizations.

Keywords: environmental sciences,nano-materials,research potential
From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV (BRAINVECTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland,Netherlands,Spain,France,Portugal,Sweden,Spain,Italy,France,Belgium
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 1597783.0
EU funding (EUR): 1597783.0
Participants: 12
Project status: CLOSED

BRAINVECTORS aims devising new gene therapy(GT)-based treatments for Parkinson’s and other neurodegenerative diseases, in substitution of current systemic treatments, by delivering neurotrophic factors (GDNF) into the CNS with new vectors derived from adeno-associated (AAV), canine adenoviruses (CAV) and lentiviruses (LV) with inducible gene expression. Although AAV, CAV and LVV are considered acceptable in terms of bio-safety, their immune response must be well characterized in order to further develop these vectors for clinical trials. Furthermore, the possibility to switch-off the expression of neurotrophic factors in case of adverse effects represents a significant pharmacological progress of the gene therapy approach for Parkinson’s disease. BRAINVECTORS will: - devise new inducible gene expression cassettes with increased sensitivity of transactivators and inducers reducing thus the dose of drugs necessary to obtain GDNF expression in brain; - characterise the immune responses induced by the components of GDNF-AAV, -CAV and -LVV in rodent models for Parkinson’s disease by using biomarker-based immunological screening. The project is based upon a network of 12 participants of public academic institutions and private non-profit organisations and SMEs in France, Germany, Italy, Netherland, Portugal, Spain, Sweden and Switzerland. Some of them are traditionally linked together in developing vectors backbones, vector production technologies and Parkinson’s animal models. Others have strong immunological background, pioneering the biomarkers-based immuno-technologies for GT vectors, and have R&D expertise/facilities on/for animal cell technologies cGMP for biopharmaceuticals. 142 p-m will be involved during 48 months in R&D and TOK activities with 72 p-m of recruited postdocs and 70 p-m of seconded staff.

Keywords: health sciences,gene vectors,brain gene therapy
Development and evaluation of a quantitative imaging technique for assessment of nanoparticle drug delivery across the blood-brain barrier: Applications for brain cancer therapeutics (ONCONANOBBB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece,United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 849958.0
EU funding (EUR): 849958.0
Participants: 3
Project status: CLOSED

The partners wish to build a long term European, Industry-Academia consortium, to work on the problem of delivering therapeutic agents, e.g. for brain cancer, across the blood-brain barrier (BBB) at the efficacious dose. Current treatment options for brain cancer are limited with patients having a poor prognosis. One of the major hurdles is the BBB which prevents effective doses of drugs reaching the site of disease. There is thus a major need for technologies that can successfully overcome such a hurdle without having a negative effect on safety and tolerability. Pharmidex have developed a drug delivery system that transiently and reversibly opens the BBB to entry of compounds into the brain without inducing tissue injury. It is based on patented lipid-like structures and has been shown to deliver both small molecules and large proteins effectively into the brain. The lead delivery compound for brain cancer appears to be safe and well tolerated on the basis of pre-clinical testing. We initially seek to determine the mechanism of action of the technology for penetrating the BBB; application to different therapeutic agents as well as development of reliable brain cancer animal models to quantify efficacy of nanoparticle-based therapy using imaging technology. We believe this novel delivery technology will be a unique drug discovery tool with the potential to enhance efficacy of established agents, reduce systemic exposure of the chemotherapeutic agent, thus minimising both the on/off-target toxicity through enhancement of drug absorption at the target site. Besides its scientific objectives, OncoNanoBBB will provide a framework for cooperation and knowledge sharing between a pharmaceutical industry and two academic institutions with complementary expertise in project objectives, as well as dissemination of project outcomes.

Keywords: health sciences,neurosciences,brain research,oncology,anticancer therapy,neurology,clinical pharmacology,neurochemistry,bbb,cns,nanoparticles,chemotherapeutics agents,drug delivery,imaging,dmpk
Sustainable Energy Research and Development Centre (SENERES)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-REGPOT-2011-1, 2011)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 2531842.0
EU funding (EUR): 2259076.0
Participants: 1
Project status: CLOSED

The main objective of the SENERES project is to set up the Sustainable Energy Research and Development Centre SENERES focusing on high efficient low-carbon energy technologies: energy generation from biomass, clean coal technologies and fuel cells. The SENERES Centre is established on the basis of the most advanced, experienced and promising research units of the Institute of Power Engineering (Warsaw, Poland) providing research in the area of energy thermal conversion and solid oxide fuel cells. The effectiveness of this project lies in gathering all existing tools and profiting from new possibilities in order to intensify its success. Therefore, the research potential of the Centre will be reinforced and developed by the cooperation with leading energy research centres in Europe: ECN (Netherland), TU Delft (Netherland), University of Cambridge (UK), CIRCE (Spain), KTH (Sweden), IFK USTUTT (Germany) and CNR-ISTEC (Italy). The project’s Action Plan foresees the exchange of know-how and experience by two-way secondments of research staff between the SENERES Centre and knowledgeable leading European research centres. Moreover, the following equally important activities will be implemented: recruitment of incoming experienced researchers, equipment modernization and upgrading, organisation of workshops and seminars together with various dissemination and promotional activities. Consequently, all SENERES Center’s actions will contribute to the EU SET-Plan for clean, efficient and low emission energy technologies development. The project will also assist in the transformation of energy systems in Central Europe Region into a more sustainable one and at the same time more secure energy supply.

Keywords: sustainable energy,biomass,clean coal technologies,furl cells
Detection of Oil in Compressed Air (DOCA) (DOCA)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Portugal,Denmark,Germany,United Kingdom,Denmark,Netherlands
Call:  (FP7-SME-2011, 2011)
Start date: 2012-09-01
End date: 2014-12-31
Duration (months): 28.0
Total project cost (EUR): 1424873.0
EU funding (EUR): 1078682.0
Participants: 7
Project status: CLOSED

The project aims to solve a major problem plaguing the industry regarding the detection of oil contaminants in high purity compressed air. It aims to develop an online sensor that will detect oil contaminants in all its forms (liquid, aerosol and vapor) with an extremely high sensitivity in accordance with ISO-8573 Class 1 standards. The lack of any reliable, highly sensitive, online sensor system has forced critical industries to rely on manual sampling and laboratory analysis which is labour intensive, inefficient, and cannot guarantee the conformance of the compressed air system to mandatory or industry adopted regulatory norms. The sensor system will benefit a large category of industries that require high purity compressed air including, hospitals, pharmaceutical, automotive, chemical, textiles, electronics, clean rooms and other related industries. The ability to detect contaminants online, will significantly enhance the capabilities of these companies to guarantee the quality of their products and eliminate a number of risks and civil liabilities that are associated with non-conformance. To achieve the project results, a consortium of 3 competent SMEs with an interest in the area of sensor development partnered with 3 leading research partners for the development of this project proposal. The major requirement for the sensor element is extremely high sensitivity, repeatability, robustness to interference, and stable calibration. It was decided after much deliberation that optical spectroscopy is the most promising technology for the development of such a sensor. We have dedicated 3 work packages (WP4, 5, and 6) for the development of 3 key components that are vital for the development of the sensor - namely development of the sampling system, development of the optical spectroscopy unit and development of electronics and software. The entire project will deliver a marketable sensor system in 2 years.

Keywords: sensor spectroscopy oil contamination detection compressed air
Modelling and optimal design of ceramic structures with defects and imperfect interfaces (INTERCER2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2011-10-01
End date: 2015-09-30
Duration (months): 48.0
Total project cost (EUR): 2398292.0
EU funding (EUR): 2398292.0
Participants: 5
Project status: CLOSED

Ceramic industry is broadly developed in Europe and the current investment is estimated at € 26 billion. With its € 9,2 billion segment, Italy is a leader country in the production of traditional ceramics, while France, UK and Germany are driving countries for advanced ceramics, growing at 21% per year. Advanced ceramics are crucial for new technologies and nano-tech applications addressed to thermo-mechanical and bio-medical applications, while traditional ceramics have a worldwide market and have been suggested as materials minimizing the impact on the environment (when compared to other finishing materials). It may seem surprising that the strong industrial production of ceramic components is still based on empirically engineered processes, often poorly understood and difficult to control (Ewsuk, 1997). Consequently, there is a relatively large production of rejects and still broad margins for further process optimization. To this purpose, in-depth scientific understanding of the production processing is required, in order to reduce costs of ceramic component design and manufacturing and to produce ceramic components more reproducibly with improved performance and reliability. In particular, forming by powder compaction, binder burnout and sintering are the most sensible processes (Reed, 1995; Rahaman, 2006). The main aim of the research project is to develop novel advanced ceramic products in close collaboration between academic and industrial partners which will be directly oriented to industrial and social needs. The goal will be achieved by (i) improvement of the powder compaction and ceramic production process; (ii) development of novel advanced ceramic multifunctional materials and structures.

Keywords: pollution reduction,energy saving,ceramic technology,manufacturing engineering,process control,engineering mathematics,numerical analysis,computational models
Understanding Interactions of Human Tissue with Medical Devices (UNITISS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,United Kingdom,Poland
Call:  (FP7-PEOPLE-2011-IAPP, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 1292204.0
EU funding (EUR): 1292204.0
Participants: 3
Project status: CLOSED

The Scientific and technological vision of UNITISS is to meet the needs of today’s healthcare industry and social expectation in reducing patient discomfort and infection and reducing the need for in vivo tests using animals. UNITISS focuses on catheterisation involving acute (< 24 hrs.) to more sustained (< 30 days) usage, where the catheters are inserted into blood vessels and the urinary tract. The project aims to develop effective in vitro tests that reliably simulate the in vivo conditions, and to develop device design strategies using improved materials and coatings that minimize the discomfort, irritation, inflammation, infection and tissue damage occurring to patients. This will be possible through developing a greater understanding of the response of human tissue to physical interactions and to new non-invasive methods of tissue monitoring. The generic knowledge and strategies developed will also be expected to have valuable medical and healthcare uses outside of the immediate focus of the project. A synergistic approach is proposed between tribology and biomaterials, based on knowledge exchange between a company (Philips, NL) strongly involved in the healthcare and well-being markets, and 2 academic partners (Univ. of Sheffield, UK and West Pomeranian University of Technology, Szczecin, PL) that have complementary strengths in biomaterials and tissue engineering. The development of general rules and methods for product validation and optimisation will enable both sectors to gain the experience and tools they need. The project encompasses 3 technical work packages, which involve material applications for model device surfaces and for the in vitro tests, investigations of the body response, and the development of the in vitro test methodologies and design strategies. Extended training will be provided to 8 ESRs and 6 ERs. A total period of 146 months of secondment and recruitment is planned, which also includes secondments of 6 very experienced researchers.

Keywords: biomaterials,tribology,materials engineering,medical devices