Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Co-Creating Positive and Sustainable Lifestyle Tool with and for European Citizens (PSLifestyle)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Estonia,Germany,Germany,Italy,Germany,Italy,Türkiye,Greece,Slovenia,Finland,Belgium,Greece,Finland,Portugal
Call: Enabling citizens to act on climate change, for sustainable development and environmental protection through education, citizen science, observation initiatives, and civic engagement (H2020-LC-GD-2020-3, 2020)
Start date: 2021-10-01
End date: 2025-03-31
Duration (months): 42.0
Total project cost (EUR): 5316802.5
EU funding (EUR): 4999871.25
Participants: 16
Project status: SIGNED

Through our consumption behaviour we, individuals, are responsible for 72 per cent of the global greenhouse gas emissions. These are created by the way we live, travel, and eat and by what we buy. So far, the attempts to change people's habits by appealing to their rationale have not produced significant behaviour change. Aiming to help close the action gap between climate awareness and individual action, and to increase citizen participation in sustainability topics, the project builds a data-driven momentum for sustainable behaviour change across eight European countries. It does this by engaging citizens through a digital application to co-research, co-develop and uptake everyday life solutions for climate change, providing tools for the collection, monitoring and analysis of their environmental and consumption data. In the application, the citizens find out how their lifestyle and habits impact the environment. They will also see a list of smart everyday actions that are relevant to reduce their environmental impact. The application enables citizens to actively create data while monitoring their lifestyle induced climate impact and behaviour. The collected data will be used to improve the application itself, and, importantly to empower citizens to gain agency in research and policy-making. The ambition is to engage a total of four million EU citizens. The figure is based on the previous national success with a web-based carbon emission calculator, which is innovated further with the use of citizen science, by co-research at living labs, co-creating personalized sustainability plans, as well as with the integration of behaviour science knowledge into the co-research and design process. The overarching goal of PSLifeStyle is to co-create a web- and mobile-based sustainable lifestyle tool and open platform, that will enable, empower and encourage European citizens to take their personalized steps towards more sustainable lifestyles.

Keywords: sustainable lifestyles,data driven sustainable everyday life,consumption carbon footprint,climate action,citizen science evidence based policy making,behavior change,living labs,systems change
PHev towards zerO EmissioNs & ultimate ICE efficiency (PHOENICE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Germany,Italy,France,France,France,United Kingdom
Call: Reducing the environmental impact of hybrid light duty vehicles (H2020-LC-GV-2020, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 5939722.5
EU funding (EUR): 4997323.88
Participants: 9
Project status: SIGNED

PHOENICE aims at developing a C SUV-class plug-in hybrid (P1/P4) vehicle demonstrator whose fuel consumption and pollutant emissions will be jointly minimized for real world driving conditions. This development will require the optimisation of a highly efficient gasoline engine, relying on a dual dilution combustion approach with excess air and EGR, synergizing an innovative in-cylinder charge motion with high pressure injection, novel ignition technologies, and an electrified turbocharger particularly relevant for hybrid architectures. The potential of alternative fuels produced by P2X processes will also be considered. To achieve the targeted near-zero emissions in transient conditions specific to PHEV in real driving conditions, the demonstrator vehicle will be equipped with a complete and dedicated after-treatment system including an electrically heated catalyst, a SCR and a GPF for abating NOx, particle number down to 10 nm, and non-regulated gaseous emissions. The vehicle overall efficiency will be increased with an exhaust waste heat recovery system for generating an additional electric power contribution for cabin heating or cooling, or for reducing the switch-on time of the internal combustion engine in cold conditions, thereby limiting the engine-out pollutant emissions such as particles. Virtual methods will be employed to reduce the calibration time of all the vehicle sub-systems. The vehicle control will use all the flexibility of the hybrid architecture and sub-systems to lower in real time the driving emissions and fuel consumption. Technologies developed in PHOENICE will achieve a TRL 7 paying a specific attention to cost, industrialization, and to the use opportunity for various vehicle classes so as to maximize the economic and environmental impacts. This project will support the European automobile industry in the medium term and speed up the transition towards a more environmentally friendly mobility in terms of air quality and GHG emissions.

Keywords: plug in hybrid,highly efficient gasoline engine,real driving emission,dual dilution combustion approach,waste heat recovery system,exhaust after treatment system,electrified turbocharger
Stereoregular Inorganic Polymer Analogues of Polyolefins (VAIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Inorganic polymers are of great interest as a result of their interesting properties, which offer exciting opportunities for their use as functional materials. Currently inorganic polymers generated through dehydrocoupling of group 13/15 amine- or phosphine-borane adducts are atactic and lack crystallinity, precluding their use in a variety of applications. The proposed research targets stereoregular polyaminoboranes and polyphosphinoboranes, inorganic analogues of stereoregular polyolefins, and potentially block copolymers, through catalytic dehydropolymerization using chiral earth abundant transition metal catalysts. The stereoregular polymers and block copolymers will be characterized in detail, and potential applications explored. To achieve these objectives a highly talented young scientist, Dr. Vincent Annibale, wishes to work in the highly multidisciplinary and internationally leading research group of Prof. Ian Manners at the University of Bristol for 2 years. Dr. Annibale has a wealth of expertise in synthetic transition metal chemistry from his previous postdoctoral and Ph.D. work. With a Marie Sklodowska Fellowship Dr. Annibale would gain exceptionally valuable experience and would become proficient in the field of polymer and materials science, which would be extremely important for his future career, preferably in academia, or in industry.

Keywords: main group chemistry,catalysis,new inorganic materials
RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Australia,Germany,Germany,Austria,Sweden,France,France,Netherlands,Netherlands,United States,Netherlands,United Kingdom
Call: Understanding common mechanisms of diseases and their relevance in co-morbidities (H2020-PHC-2015-two-stage, 2015)
Start date: 2015-11-01
End date: 2020-04-30
Duration (months): 54.0
Total project cost (EUR): 6469522.5
EU funding (EUR): 5999431.25
Participants: 15
Project status: CLOSED

RELENT is multidisciplinary group of scientists and clinical investigators whose goal is to develop individualized treatment for chronic autoimmune diseases, such as rheumatoid arthritis and vasculitis, that cause considerable mortality and morbidity, both from uncontrolled disease and treatment associated co-morbidities, like infection and malignancy. This requires the need to stratify patients by their outcome and to tailor immunosuppression based on much deeper knowledge of the mechanisms that control initiation and persistence of the pathogenic immune responses. The RELENT Consortium has been formed to generate this knowledge with the ultimate goal of developing treatments tailored to the specific needs of individual patients. RELENT combines the resources of seven leading European Investigators and two from US and Australia whose expertise is not available elsewhere in the world but necessary for the ambitious work program. Three SMEs will supply specific reagents and translate the results to biomarker development. This will enable RELENT to deliver its four specific research aims, namely to: i) Combine subset analysis of genome wide association studies with classical cell biology to uncover pathways that influence and ii) use multiplexed antigen arrays, whole proteome analysis and rapid mass analysis to identify protein signatures that predict outcome and response to treatment in chronic autoimmune disease. iii) Characterise T and B cell abnormalities that predispose to autoimmunity and infection by studying the ageing immune system in health and disease. iv) Analyse pathogenic effector T cells and their control by macrophages and dendritic cells and the molecules they secrete using in vivo models. We anticipate to identify common mechanisms responsible for the persistence and outcomes in severe autoimmune and inflammatory diseases in females and males and that the results should be rapidly translatable into clinical practice for the benefit of patients.

Keywords: chronic autoimmunity,prevention,relapse,targeted treatment,inflammatory signatures,regulatory pathways,immunosenescence
Analysing the migration choices of HIV-positive gay men in England and France (HIVGAYM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-08-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Despite improvements in available therapies and investments in prevention campaigns, HIV-rates continue to rise across European cities. Gay men are over-represented amongst people with HIV, thus experiencing the combined effects of homophobia and HIV-related stigma. Several studies have found a correlation between becoming HIV-positive and gay men’s decision to migrate, although most of them rely on quantitative methodologies and concern the US and Canada. In a European context we have very limited knowledge about the reasons why HIV-positive gay men choose to migrate to, and remain in, specific urban areas across the continent. This research project aims at addressing this gap in knowledge by investigating different migration patterns of HIV-positive gay men towards Birmingham and Brighton (England) and Marseille and Paris (France) at different historical times (the mid ‘80s/early ‘90s with the diffusion of the epidemic and a stigmatizing public discourse; the mid ‘90s/early 2000s with a new focus on prevention from health institutions and the introduction of effective therapies; the last decade with the introduction of a single drug-therapy and the recent introduction of Pre-Exposure Prophylaxis, PrEP). To better understand the complexity of factors pushing people to relocate and the perception of stigma in previous places of residence, data will be collected through questionnaires; in-depth interviews with both HIV-positive gay men of each generation and relevant stakeholders/policy-makers; and archival work to collect HIV-prevention campaigns, public health information and media news and reports among others. By shedding light on the dynamics of stigmatization still affecting HIV-positive gay men, the research project will provides an evidence base for policy makers and service providers in order to make their intervention for the well-being of HIV-positive gay men more effective.

Keywords: gay men,migration,welfare regime,stigma,england,france
Automatic Control of Anaesthesia (ACTAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

This proposal addresses the automatic control of anaesthesia and the objective of developing an efficient and robust solution to increase patient safety and reduce post-operative complications. Automatic anaesthesia control is seen as one of the most important ways of achieving this goal. The control system should be able to provide significant benefits such as reducing the anaesthesiologist’s workload, limiting the influence of the human factor and minimizing the amount of drugs used. In this context, patient safety will be improved thus tackling both a severe public health problem and the significant economic burden on limited health resources. This project will use a novel event-based model predictive control approach for the anaesthesia process, addressing the key questions of efficient drug use, robustness regarding inter/intra-patient variability as well as considering its implementation and evaluation on real patients. The proposed approach has many advantages that can be useful in clinical practice such as adapting the actuation rate to the state of the patient, thanks to its predictive capabilities and event-based approach. The main objective is to develop new control approaches and optimize their performance in order to meet clinical requirements. Through the presented research, it will be possible to push the theoretical developments to the next stage, making them valuable milestones in the extensive implementation of automatic control techniques in the anaesthesia process. Moreover, an automatic control system can limit the influence of the human factor and provide a more unified solution for the anaesthesia process based on novel approaches. Activities developed under this proposal provide a unique opportunity to improve the quality of life of EU citizens and to reinforce the EU position as a central player in the global context through the high quality innovative multidisciplinary research.
Spinal Muscular Atrophy (SMA) beyond motoneuron degeneration: multi-system aspects (SMABEYOND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Spain,Italy,Germany,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 2142734.76
EU funding (EUR): 2142734.76
Participants: 9
Project status: SIGNED

Spinal Muscular Atrophy (SMA) is a monogenic motoneuron disease with a neuromuscular phenotype resulting in infant death in severe cases. Besides motoneurons in the central nervous system (CNS), there is growing evidence of an involvement of peripheral organs. SMA is caused by reduced Survival of Motoneuron (SMN) protein levels and SMN is ubiquitously expressed. Therefore, SMA patients show reduced SMN levels also in peripheral organs. A restoration of SMN levels in the CNS is a potent therapeutic strategy which led to the approval of two different compounds: Spinraza is an antisense oligonucleotide which increases SMN mRNA, Zolgensma is an adeno-associated virus increasing expression of SMN. However, both strategies focus on the restoration of CNS SMN levels without a sustainable effect on peripheral organs. In 2020, approval of a third drug, Risdiplam, a systemic SMN enhancer, is expected. Although patients greatly benefit from a treatment of the neuromuscular phenotype they face a precarious future: there is no comprehensive landscape of vulnerable organs and no approved treatment for the periphery. We will analyze intrinsic defects in peripheral organs (WP1), evaluate the organ specific molecular and cellular functions of the SMN protein in relevant organs (WP2), and translate these findings to SMA patient derived models, which we will treat with a systemic SMA drug currently under clinical evaluation (WP3). The SMA field involves stakeholders, which allow early stage researchers to personally interact with basic scientists, clinicians, pharmaceutical companies and patient organizations. For our training network, we will combine this vertical integration with a broad perspective on multiple organ systems in SMA. The training strategy assures career options and employability of early stage researchers beyond the SMA field. We will go beyond the motoneuron and identify organs, mechanisms and molecules that could be targets for the peripheral aspects of SMA.

Keywords: spinal muscular atrophy,rare disease,neurodegenerative disease,non neuronal phenotypes
Immune Monitoring for RIsk STratification in Solid Organ Transplant Recipients (ImMoRiSt)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year ~ 40.000 patients throughout the EU are transplanted a new kidney, lung, liver, heart or another organ. The frequency of clinical complications is relatively high because at present there are no diagnostic tests that help physicians to determine the right dosage of immunosuppressive drugs necessary to avoid both organ rejection and clinical complications caused by infections. Lophius Biosciences GmbH has developed I-Scan, a functional immune monitoring test that within 24 h provides important information on the strength of the immune system in solid organ transplant recipients. I-Scan uses a proprietary cocktail of stimulants that selectively stimulate the clinically relevant immune cells in a patient’s blood sample. The detection of the triggered interferon γ (IFN-γ) release provides a qualitative and quantitative measurement of cell-mediated immune function. The feasibility study performed during Phase 1 will explore issues related to both, the clinical biomarker validation study and the best market entry strategy. Several objectives are pursued in parallel and encompass: • Setting up the business plan which includes a competitor as well as a freedom-to-operate analysis and a market entry strategy. • Selection of clinical study partners and defining the design of the clinical study, best suited to yield highest clinical evidence • Obtaining regulatory approval for the planned clinical study and setting a strategy to obtain regulatory approval / CE-Marking for final I-Scan products. Lophius will apply for Phase 2 funding of a clinical study to validate that I-Scan improves the outcome of SOT patients. This study is likely to take place in Germany, Switzerland and Austria where Lophius has already established firm links to transplantation centers. The study is the logical next step to further grow Lophius to become a global leader in the IVD market for immunomonitoring

Keywords: immunomonitoring,risk stratification,solid organ transplantation,cell mediated immunity
Fairness and the Moral Mind (FAIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Norway
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The project provides a comprehensive and groundbreaking approach to the analysis of the moral mind and inequality acceptance. The first part of the project will provide a novel study of how the moral ideals of personal responsibility and individual freedom, which are fundamental values in most liberal societies, shape inequality acceptance. It will also provide the first experimental study of how people draw the moral circle, which is at the heart of the most pressing policy challenges facing the world today and strongly related to the question of global fairness. The second part will study how social institutions shape inequality acceptance and how it develops in childhood and adolescence, by providing two unique international studies of inequality acceptance in 60 countries across the world. These studies will provide novel insights on the distributive behavior of nationally representative samples of adults and children and on the cultural transmission of moral preferences in society. The project is rooted in behavioral and experimental economics, but will also draw on insights from other social sciences and philosophy. It will develop novel experimental paradigms to study the moral mind and the nature of inequality acceptance, including incentivized experiments on nationally representative populations, and combine structural and non-parametric empirical analysis with theory development. Taken together, the project represents a unique study of inequality acceptance in the social sciences that will address an important knowledge gap in the literature on inequality.

Keywords: fairness,inequality,personal responsibility,individual freedom,paternalism,moral mind