Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Future Media Internet Coordination Action (NEXTMEDIA)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Greece,United Kingdom,Italy
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2009-11-01
End date: 2011-10-31
Duration (months): 24.0
Total project cost (EUR): 1224636.0
EU funding (EUR): 929878.0
Participants: 6
Project status: CLOSED

The objective of nextMEDIA is to enhance the coordination of the efforts in Europe towards producing a clear situation of the Future Media Internet, create common pillars (e.g. the Future Media Internet reference architecture for Europe) and support the results of the developments of the European projects by means of the following actions: • Coordinate and Support of research collaboration in networked media scientific fields, especially in Future Media Internet (with strong orientation to the combination of 3D Internet Media and Content-aware Networks/Network-aware applications) • Support the cooperation and future research of the European projects in the field of Networked Media by means of driving Task Forces and propose and coordinate new ones (“Future Media Internet Architecture”). • Identify the position and clear opportunities in the areas where the European research in Future Media Internet is more competitive world-wide and develop studies and roadmaps by means of analysing the situation, technology and patents in the most developed countries in relevant research areas. • Create the necessary dissemination means to advertise and spread excellence of the European research in Future Media Internet world-wide and attract the prominent scientists and company managers to the events. The results of the nextMedia coordination action will be used to promote and disseminate the common European position, by accessing different channels, such as stakeholder workshops and exchange of best practices. The project will use the results of the information gathering and best practice identification and definition, and will disseminate them to the community at large. For each of the stakeholder groups belonging to this community a set of recommendations on how to mainstream these results into their research activities, policies and strategies will be developed.

Keywords: future media internet,3d media,future content networks,coordination action
Defects in DNA strand break repair and links to inheritable disease (DNAREPAIR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2449091.4
EU funding (EUR): 2449091.4
Participants: 2
Project status: CLOSED

Our genetic material is continually subjected to damage, either from endogenous sources such as reactive oxygen species produced as by-products of oxidative metabolism, from the breakdown of replication forks during cell growth, or by agents in the environment such as ionising radiation or carcinogenic chemicals. To cope with DNA damage, cells employ elaborate and effective repair processes that specifically recognise a wide variety of lesions in DNA. These repair systems are essential for the maintenance of genome integrity. Unfortunately, some individuals are genetically predisposed to crippling diseases or cancers that are the direct result of mutations in genes involved in the DNA damage response. For several years our work has been at the forefront of basic biological research in the area of DNA repair, and in particular we have made significant contributions to the understanding of inheritable diseases such as breast cancer, Fanconi anemia, and the neurodegenerative disease Ataxia with Oculomotor Apraxia-1 (AOA-1). The focus of this ERC proposal is: (i) to define the phenotypic interplay between three inheritable cancer predisposition syndromes, Fanconi anemia, Bloom s syndrome and breast cancers caused by mutation of BRCA2, (ii) to determine the biological role of the newly discovered GEN1 Holliday junction resolvase in homologous recombination and repair, and (iii) to understand the actions of Aprataxin and Senataxin in relation to the inheritable neurodegenerative diseases AOA-1 and AOA-2, respectively. Our studies will provide an improved understanding of basic mechanisms of DNA repair and thereby underpin future therapeutic developments that will help individuals afflicted with these diseases.

Keywords: tumourigenesis,human disease,dna damage response,recombination,repair
GraphRules: Rule Discovery, Exploration and Visualization of Collaborative Graph Structures (GRAPHRULES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In this proposal we will offer a unified view of graph mining systems and recommender systems. We propose a system that monitors the time evolution of graph entities (such as customer-product graphs) and allows for a broad set of knowledge extraction operators. The proposed system will feature advanced collaborative tagging techniques, which we call 'auto-tagging' that aim at automating information extraction about the monitored graph entities from various web sources, such as RSS feeds, blog posts and news events. The system will offer several exhiting innovations such as: - Incorporation of Ontologies and hierarchies on top of the graph structure - Automatic expansion of entity information from diverse web sources - Interactive Exploration of the graph space - Knowledge extraction algorithms, including clustering and bi-clustering, recommendations, anomaly detection and prediction.

Keywords: computer science,data mining,knowledge extraction,graph mining,rule discovery,recommender systems,time-series
Descriptive Set Theory and Operator Algebras (DSTOA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark,Austria
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 2
Project status: CLOSED

We propose an investigation into various classification problems and problems of Set Theoretic nature arising in Operator Algebras. The particular focus of the project is on the classification problem of group-measure space factors arising from an ergodic a.e. free action of a non-amenable group, on the classification problem of ITPFI factors, and on the classification of the consistent possibilities of the structure of automorphisms of the Calkin algebra.

Keywords: physical sciences,mathematics,mathematical logic,functional analysis
Unravelling the mechanism for development of WASP-associated primary immunodeficiency (WASPSTINGS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Two severe primary immunodeficiencies; Wiskott-Aldrich syndrome (WAS) and X-linked neutropenia (XLN), are caused by mutations in the same gene encoding the WAS protein (WASP). WASP is a hematopoietic cell-specific cytoskeletal regulator that coordinates receptor signalling to changes in the actin cytokeleton, thereby altering migratory, adhesive, phagocytic, and signalling responses. WAS is caused by loss-of-function mutations in WASP. WAS patients and WASP-deficient mice are immuno-compromised, fail to respond to foreign pathogens, and are prone to develop eczema and autoimmune disease. In contrast, XLN is caused by gain-of-function mutations that lead to a constitutively-active WASP. XLN patients suffer from severe congenital neutropenia. It remains unknown how different mutations in WASP can induce vastly diverse clinical phenotypes. I hypothesize that similar to WASP deficiency, XLN-WASP mutations may affect hematopoietic cells broadly. Moreover, I hypothesize that altered tolerance to self leads to induction of eczema and autoimmunity in WAS patients and WASP-deficient mice. I propose; AIM 1: To reveal the underlying cause for development of XLN by usage of a novel mouse model that I generated during my postdoctoral work. We will determine how XLN-WASP influences the immune response, induces neutropenia, and tumour transformation. AIM 2: To investigate how WAS patients and WASP-deficient mice that fail to respond to foreign pathogens still react vigorously to self and develop eczema and autoimmunity. This project is carried out as a multidisciplinary and translational collaboration together with my postdoctoral mentors in the USA, and researchers in Italy, England, and Sweden. The long-term goal with the project is to increase the mobility of European researchers and the European excellence by defining future targets for therapeutic intervention and to understand the requirement of WASP and the actin cytoskeleton for correct function of hematopoietic cells.

Keywords: immunology,primary immunodeficiency,wiskott-aldrich syndrome,x-linked neutropenia,eczema,patient samples,novel mouse models
Protease signaling in development and disease. (PROTEASE SIGNALING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Protease- activated receptors (PARs) comprise a family of four G-protein coupled receptors that mediate cellular responses to proteases. PARs were identified in a search for the platelet receptor for the coagulation protease thrombin. Mouse deficiency models later established critical roles for PARs in hemostasis and thrombosis and in vascular development, yet unexplained functions ascribed to proteases hinted at a broader functional repertoire. To uncover new roles for PARs, we addressed redundancy between PARs and found that combined loss of all PARs in mice resulted in embryonic lethality not accounted for by bleeding or lack of endothelial signaling, suggesting unappreciated roles for PARs in development. Addressing redundancy with other signaling systems, we found that loss of plasma sphingosine-1-phosphate (S1P), a lipid agonist for a related family of G-protein coupled receptors, had profound effects on endothelial barrier homeostasis including sensitization to barrier modulation by PARs. This proposal aims to explore a novel role for PARs in development of the cardiovascular system and to study the role of PARs and S1P receptors and their interaction in endothelial barrier homeostasis. Better understanding of PARs, their agonist proteases and redundant signaling systems in embryonic development and adult disease may refine the use of existing and emerging drugs targeting this system and, potentially, expand their application beyond current indications.

Keywords: health sciences,animal embryology,cell biology,molecular genetics,genetic engineering
Stochastic Analysis, Mass Transportation and Free Probability (SAMTFP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Romania
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

There are three different topics related to this project. The first one is an interplay between probability and Morse theory. The main idea is to exploit in the probabilitisc framework a suggestion of Witten and recover the Morse-Smale complex of a Morse function using asymptotics of Wiener functionals. The second topic is the study of transportation cost inequality on the path space of a Riemannian manifold and its connections with Log-Sobolev and HWI inequality of Otto-Villani. There were some attempts in the literature but it seems that the appropriate distance is yet to be settled. The third topic is in free probability. This regards first, second and higher order asymptotic freeness of Wigner ensembles and constant matrices. The results are to be applied to the study of random matrices with dependencies. Regarding functional inequalities in free probability, the standard tool is the random matrix approximation. The investigator used mass transportation thechiques to provide proofs of some of these inequalites in one dimensional free probability for measures on the line. Part of this proposal is an extension of these results to measures on the circle or in plane as well several noncommutative random variables.

Keywords: probability theory,functional analysis
Mechanisms that underlie loss of antigen tolerance in HLA-associated autoimmune diseases (IMMUNE TOLERANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

An estimated 3-7% of Europe&apos;s population (80% females) suffer from autoimmune diseases (AID) that affect the body's various organs. In healthy people, harmless proteins from self, bacterial flora or food do not elicit a destructive inflammatory response due to antigen tolerance. Central to antigen tolerance is the function of regulatory T cells, a population of lymphocytes key to the prevention of excessive inflammatory tissue damage by immune effector cells. Unfortunately, the mechanisms that safeguard a balanced interaction of HLA class II-restricted regulatory and effector CD4+ T cells are incompletely understood. This explains why the current treatment of AID remains inadequate. Towards the priority research areas for chronic inflammatory diseases identified in the Innovative Medicines Initiative&apos;s Research Agenda 2008, we suggest the following original approaches: 1.) Identification of the functional roles of HLA class II-restricted CD4+ T cells in the induction/prevention of AID using a HLA-DR*0405 transgenic mouse model of autoimmune pancreatitis (AIP); 2.) identification of humoral autoantigens that can aid in the diagnosis of AIP; 3.) enhancement of a novel mouse model of human celiac disease (CD) by introduction of the CD-associated HLA-DQ8 (class II) allele; and 4.) pre-clinical testing of oral enzyme therapy, currently the most promising alternative treatment approach to CD, comparing efficacy in the existing CD mouse model of a 2-enzyme-glutenase (prolyl endopeptidase and endoprotease B2) vs. an extract of germinating wheat enzymes. This project will lead to insight into pathomechanisms that underlie loss of antigen tolerance in HLA-associated AID, development of a diagnostic serum test for AIP, analysis of the HLA-dependency of CD-specific autoantibodies and proof-of-efficacy in vivo for oral enzyme therapy of CD.

Keywords: antigen tolerance,autoimmune diseases,celiac disease,autoimmune pancreatitis,mucosal immunology,intestinal disorders,hla class ii,t cell subsets,gastroenterology,rheumatology
HeisenData - Towards a Next-Generation Uncertain-Data Management System (HEISENDATA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Several real-world applications need to manage and reason about large amounts of data that are inherently uncertain. For instance, pervasive computing applications must constantly reason about volumes of noisy sensory readings, e.g., for motion prediction and human behavior modeling; information-extraction tools can assign different possible labels with varying degrees of confidence to segments of text, due to the uncertainties and noise present in free-text data. Such probabilistic data analyses require sophisticated machine-learning tools that can effectively model the complex correlation patterns present in real-life data. Unfortunately, to date, approaches to Probabilistic Database Systems (PDBSs) have relied on somewhat simplistic models of uncertainty that can be easily mapped onto existing relational architectures: Probabilities are typically associated with individual data tuples, with little or no support for capturing data correlations. This research proposal aims to design and build a novel, extensible PDBS that supports a broad class of statistical models and probabilistic-reasoning tools as first-class system objects, alongside a traditional relational-table store. Our proposed architecture will employ statistical models to effectively encode data-correlation patterns, and promote probabilistic inference as part of the standard database operator repertoire to support efficient and sound query processing. This tight coupling of relational databases and statistical models represents a major departure from conventional database systems, and many of the core system components need to be revisited and fundamentally re-thought. The proposed research will attack several of the key challenges arising in this novel PDBS paradigm (including, query processing, query optimization, data summarization, extensibility, and model learning and evolution), build usable prototypes, and investigate key application domains (e.g., information extraction).

Keywords: relational database systems,probabilistic/uncertain data management,query processing,query optimization,statistical models,probabilistic inference
EMERGENT HEALTH-CARE OCCUPATIONS & QUALITY OF LIFE: A STUDY OF THE USA, SPAIN & ITALY (EHCO & QOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project aims to understand the dynamic structuring of emergent occupational and organizational forms in health care services. Employment growth in health related fields leads labor markets today. This growth results from a well known economic and demographic phenomenon affecting mostly Europe and North America, namely, the increasing demand for healthcare and social assistance because of an aging population and longer life expectancy. These social changes imply more than just a growing need for management of the expanding provision of health care and social services. They also mean profound transformations in the institutional and social settings where care is given, as the health care system moves away from large hospitals and centers around focused-care organizations and individuals’ homes. However, limited research exists concerning the effect of these changes on the emergence of new occupations and the need for multidisciplinary work approaches in caring for the aged. In addition, there is little in understanding the educational programs necessary to develop competencies in these jobs. Because these trends encompass large geographical regions (Europe and USA) and involve different disciplines such as health management, labor relations and sociology of work, the Researcher has built an international and interdisciplinary team of scholars from the USA, Italy and now Spain. Overall, the project aims to achieve: (a) an understanding of health caregivers’ jobs and the design of a corresponding educational program, that would permit employees to effectively deliver quality care; (b) an adequate definition of healthy elderly quality of life (QOL), departing from the multiple conceptualizations currently used in research; and (c) a theoretical framework that would help categorize the growing number and type of organizations and occupations in the health care sector.

Keywords: health care occupations,older population care,health services organizations,human capital development,quality of life,social sciences,sociology of labour
Understanding the Origin of Mass with the ATLAS experiment at the Large Hadron Collider (HIGGS-ZAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-04-15
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

We are proposing a research programme to explore the origin of mass for fundamental particles through searching for the Higgs boson in the early data from the ATLAS experiment at CERN&apos;s Large Hadron Collider. To optimise our search strategy and the discovery potential of ATLAS, we will first invest in developing tools for validating the detector performance and the quality of the recorded data, and we will make measurements of some benchmark particle physics processes, which will allow us to confirm our understanding of the ATLAS detector and the Standard Model of particle physics in this completely new energy regime. These processes are at the same time important backgrounds for the Higgs search and their study will strengthen our Higgs discovery capabilities. This proposed project is at the forefront of fundamental research and is extremely timely, with the LHC starting up later this year. It will be instrumental for the career prospects of the fellow, as she will be involved in one of the highest profile research topics to date, and it will have significant benefits to the host institute thanks to the expertise the fellow will bring.

Keywords: particle physics,large hadron collider,higgs boson,electroweak theory