Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals (One-Flow)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Austria,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3896827.5
EU funding (EUR): 3896827.5
Participants: 8
Project status: CLOSED

ONE-FLOW translates ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep horizontal hierarchy manageable, orthogonality among the consecutive reactions needs to be increased. The winning point of nature is to have invented catalytic cascades. ONE-FLOW will uplift that by enabling the best bio- and chemocatalysts working hand in hand. 4 synthetic flow cascades ('metabolic pathways’) and 1 flow cascade driven by automated intelligence ('signaling pathway') will produce 4 Top-list 2020 drugs. ‘The Compartmentalized Smart Factory’ will develop organic, inorganic, and mechanical compartmentalization. ‘The Green-Solvent Spaciant Factory’ will fluidically allow the use of interim reaction spaces (spaciants). ‘The Systemic Operations Factory’ will aim at full orthogonality using data-base guided ultimate process harmonization. ‘The Digital Machine-to-Machine Factory’ will alter the landscape of chemical synthesis by virtue of the "Internet of Chemical Things". Automated machine-to-machine data transfer enables relegation of process monitoring to central computer systems under the oversight of chemists. ‘The Fully Continuous Integrated Factory’ will develop a commercial platform technology under the auspices of sustainability-driven process-design evaluation, making amenable the new kind of processing to all chemists. ONE-FLOW has massive impact potential: i) 38 billion Euro production cost saving; ii) 300 million EUR cost saving per drug; iii) address diseases with 500 billion Euro medication costs; iv) increase market share of emerging high-tech SME players by 10% in 10 years; v) open new windows of opportunity (personalized medicine) with 200-500 million Euro per disease; and vi) achieve 40% female share on a senior scientist level (ONE-FLOW: 34% senior, 57% junior).

Keywords: compartmentalization of catalysts,continuous synthesis and purification,cascade reactions in,flow,pharmaceuticals,biocatalysis,heterogeneous catalysis,internet of chemical things
Information-age microscopy for deep vision imaging of biological tissue (DEEPVISION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-11-30
Duration (months): 69.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Modern biology could not exist without the optical microscope. Hundreds of years of research have seemingly developed microscopes to perfection, with one essential limitation: in turbid biological tissue, not even the most advanced microscope can penetrate deeper than a fraction of a millimetre. At larger depths light scattering prevents the formation of an image. DEEP VISION takes a radically new approach to microscopy in order to lift this final limitation. Microscopes are based on the idea that light propagates along a straight line. In biological tissue, however, this picture is naive: light is scattered by every structure in the specimen. Since the amount of ‘non-scattered’ light decreases exponentially with depth, a significant improvement of the imaging depth is fundamentally impossible, unless scattered light itself is used for imaging. In 2007, Allard Mosk and I pioneered the field of wavefront shaping. The game-changing message of wavefront shaping is that scattering is not a fundamental limitation for imaging: using a spatial light modulator, light can be focused even inside the most turbid materials, if ‘only’ the correct wavefront is known. DEEP VISION aims to initiate a fundamental change in how we think about microscopy: to use scattered light rather than straight rays for imaging. The microscope of the future is no longer based on Newtonian optics. Instead, it combines new insights in scattering physics, wavefront shaping, and compressed sensing to extract all useful information from a specimen. Whereas existing microscopes are ignorant to the nature of the specimen, DEEP VISION is inspired by information theory; imaging revolves around a model that integrates observations with statistical a-priori information about the tissue. This model is used to calculate the wavefronts for focusing deeper into the specimen. Simulations indicate that my approach will penetrate at least four times deeper than existing microscopes, without loss of resolution.

Keywords: wavefront shaping,microscopy
Fast and easy previsualisation for creative industries (first.stage)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Spain,Denmark,United Kingdom
Call: Technologies for creative industries, social media and convergence (H2020-ICT-2015, 2015)
Start date: 2016-06-01
End date: 2019-09-30
Duration (months): 40.0
Total project cost (EUR): 3031510.0
EU funding (EUR): 3031510.0
Participants: 9
Project status: CLOSED

Previsualisation is an essential phase in the design process of narrative art forms and media such as film, animated series, and stage plays. The possibilities that digital tools bring to this phase of production are immense, allowing early visualisations that support making creative decisions with much lower cost of changes than at later stages of production. Yet these tools require trained skills that are not available in typical small- to medium-size productions. The goal of the first.stage project is to provide a toolset that brings the power of digital previs to productions in key application areas by being easier and thus cheaper to use: professionals can use these tools in practice immediately without large investment. This will make previs easier and faster, with significant benefits for production quality. The first.stage toolset will employ natural user interfaces that utilise innate abilities and existing skills of artists for key tasks in previsualisation. Visual elements can be selected from asset libraries via expressive commands, while physical media such as figurines or stage models can be integrated by 3D digitisation. Elements can be arranged and views defined by gestures. Characters, cameras, and scenes can be animated by demonstrating the desired behaviour in the style of performance animation. This functionality will be based on state-of-the-art asset libraries, engines and motion capture hardware. The novel approach to previs that first.stage takes will have a direct impact on Europe’s storytelling industries – from the film industry over tv /commercials to theatre and other stage productions. It will give key creative personnel – (art) directors, choreographers, and concept artists – more artistic hold over productions. Accessible previs tools will further have impact on related fields such as architecture or product design, down to effects in education programmes and off-market and laymen creative endeavours.

Keywords: previsualisation,narrative visual arts,computer animation,natural user interfaces,motion capture
Single-molecule analysis of Holliday-junction (HJ) migration by the human double-HJ dissolvasome (HJMIGRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Hungary
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 146239.2
EU funding (EUR): 146239.2
Participants: 1
Project status: CLOSED

The project outlined here investigates the molecular mechanisms of the critical final steps of homologous recombination (HR) based DNA repair, a pathway that supports the error-free repair of double-stranded DNA breaks (DSBs). In HR, the broken DNA ends are processed and homologous DNA provides a template for repair. Engagement of both processed ends leads to the formation of a double Holliday-junction (DHJ) structure. DHJ can be resolved by enzymatic cleavage or dissolved by the concerted action of a specialized group of helicases (RecQ-family helicases including Bloom’s syndrome helicase (BLM)) and Type I topoisomerases (e.g. TOP3A). In humans the ‘dissolvasome complex’ consists of BLM, TOP3A and regulatory proteins (RMI1, RMI2), called the BTR complex. The BTR complex dissolves DHJ by 1. convergent branch migration of the two independent HJs and 2. decatenation of the final hemicatenate structure. Thus, dissolution solely results non-crossover products, which is necessary to avoid chromosomal rearrangements. What is the mechanism of HJ migration? What are the exact roles of the subunits of the BTR complex? How long can a HJ migrate (i.e. how processive is the ‘dissolvasome’)? How specific is the DHJ migration to the BTR complex compared to other human RecQ helicases? Here we aim to address these questions by using state-of-the-art single-molecule and solution biophysical and biochemical techniques. We will generate a previously inaccessible mobile HJ substrate integrated into λ-bacteriophage DNA. We will follow the processes underlying HJ migration by fluorescently labeling the BTR complex, HJ position and DNA end in total internal reflection fluorescence (TIRF) microscopy combined with microfluidics. Elucidation of the detailed roles of the BTR components in HJ branch migration will help us to understand their roles in genome maintenance.

Keywords: homologous recombination,branch migration of holliday junction,recq helicases,bloom s syndrome,single molecule analysis,tirf microscopy,microfluidics,genome maintenance
Cloning and functional characterization of a complex resistance locus from ‘Geneva’ to breed apple cultivars with durable scab resistance (GENEVABREED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,New Zealand
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 238354.2
EU funding (EUR): 238354.2
Participants: 2
Project status: TERMINATED

Apple scab caused by Venturia inaequalis is the major constraint to apple production worldwide, causing severe economic losses. As current commercial cultivars are highly susceptible to scab, introduction of new scab-resistant cultivars will reduce the intensive use of pesticides now required to control this disease. Although the ‘Geneva’ apple is an important source of resistance for breeding, its complex scab resistance has not been properly characterized. In preliminary studies, we mapped to chromosome 4 of ‘Geneva’ a 5 cM region containing three genes conferring both dominant and recessive scab resistance, which corresponds to a 2 Mbp region containing nine candidate NBS-LRR resistance genes on the physical map of ‘Golden Delicious’ (GD). This provided the first evidence of recessive genetic control of apple scab resistance. In this project proposal, we will further characterize this complex locus, employing next generation sequencing, together with bioinformatics and functional analysis of disease candidate resistance genes (CRGs): (1) we will sequence the resistance locus in ‘Geneva’ and identify CRGs that are polymorphic (presence/absence, or sequence polymorphism) between the resistant ‘Geneva’ and the susceptible GD; (2) we will clone each CRG with its native promoter, terminator and introns; and (3) transform susceptible lines with the individual CRGs to evaluate their effect on the level of disease resistance and its race-specific spectrum. This will not only build a better understanding of the genetic basis of apple scab resistance and the gene-for-gene relationships between the pathogen and the host, but it will enable the development of molecular markers for breeding new ‘sprayfree’ cultivars with durable scab resistance.

Keywords: apple,disease,scab,resistance,candidate resistance gene,cloning,genetics,bioinformatics,plant transformation,agrobacterium transient gene expression
Advanced Hand Sanitizing and Compliance System for the Healthcare Sector (BioDermaCare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Across the EU four million patients are affected by hospital acquired infections (HAI) every year, causing pain, longer stays in hospital, long-term disabilities and increased resistance to antimicrobials. Around 37,000 people die each year due to a HAIs. The cost is almost €7 billion a year with an average cost of €9,000 per case. Many of these infections, deaths and costs can be reduced by improved hand sanitization. Resani has developed a game-changing Automatic Hand Sanitizer (AHS) solution for improved hand disinfection of healthcare workers including those who suffer from occupationally acquired eczema which often harbours microbial biofilms including Staphylococcus Aureus. Our solution encourages regular use by using a patented eczema- friendly antiseptic which destroys biofilms and reminds staff to sanitize through an app and monitors use through a IoT badging system. The only automated hand sanitizer that guarantees 100% coverage of the hand in 3 seconds without rubbing the hands together or need to dry. The Resani AHS will increase hand sanitizing compliance from 37% to 100% among HCW and will provide hospital administrators with real-time data for statistical analysis, reporting and overall improvement of hand sanitization protocols. We will sell the AHS directly to hospitals and through channel distributors. Resani will also sell the special antiseptic refill cartridges, that are custom made to work with the AHS.

Keywords: hospital acquired infections,hand sanitization,eczema,mrsa
CONtract SOLutions for Effective and lasting delivery of agri-environmental-climate public goods by EU agriculture and forestry (CONSOLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Spain,Ireland,Italy,Italy,Italy,Italy,Germany,Belgium,Bulgaria,Poland,Finland,Latvia,France,France,Netherlands,Netherlands,United Kingdom
Call: Contracts for effective and lasting delivery of agri-environmental public goods (H2020-RUR-2018-2, 2018)
Start date: 2019-05-01
End date: 2022-10-31
Duration (months): 42.0
Total project cost (EUR): 4999998.75
EU funding (EUR): 4999998.75
Participants: 25
Project status: SIGNED

The objective of CONSOLE is to boost innovation in the lasting delivery of agri-environmental-climate public goods (AECPGs) by EU agriculture and forestry. To achieve this objective, CONSOLE builds a Community of Practice (CoP) to cocreate an empirically validated contractual framework, design and test effective and efficient contract models and support their implementation by multiple actors. The CONSOLE multi-actor and multidisciplinary team brings together 24 partners in 13 countries, covering representative typologies of actors involved in AECPGs contracts design and implementation (farmer organisations, regional administrations, consultancy companies, research institutions and water and forest management bodies). The CONSOLE framework will allow improved design and facilitate implementation of innovative contract solutions for the provision of AECPGs under various conditions across the EU. The CONSOLE framework includes: a) a catalogue showcasing successful experiences and good practices in AECPGs contracting and cooperation models; b) improved AECPGs contracts solutions and their assessment for different levels of governance; c) a comprehensive guide to the process for the design of AECPGs contracts; d) documentation, training and supporting materials. CONSOLE includes a comprehensive analysis of at least 52 case studies of existing experiences encompassing land tenure arrangements, result-based approaches, collective implementation and value chain-based remuneration, supported by surveys and modelling. Building upon these experiences, improved contract solutions will be developed in collaboration with the CoP. The CONSOLE framework will be tested in real decision-making contexts and will develop into a supporting tool for actors in the field, enabling the delivery and sustainability of AECPGs. Insights will improve policy design towards the achievement of the Sustainable Development Goals, in particular through environmental policies and the post-2020 CAP.

Keywords: agri environmental climate public goods,agri environmental climate contracts,result based payments,collective actions,land tenure,co construction,community of practice
Institutionalized Integrated Sustainable Energy and Climate Action Plans (2ISECAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Estonia,Spain,Italy,Spain,Italy,Slovenia,Switzerland,Greece,Switzerland,Greece,Greece,Netherlands,Denmark
Call: Supporting public authorities in driving the energy transition (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 1499662.5
EU funding (EUR): 1499662.5
Participants: 17
Project status: SIGNED

The project ‘Institutionalized Integrated Sustainable Energy and Climate Action Plans’ (2ISECAP) aims to bridge the gap between local sustainable energy planning and implementation by supporting the capacity building of public authorities and by developing interface capacities within public authorities to engage with civil society towards energy transition. 2ISECAP will attempt the creation of an institutional environment for effective decision-making processes combining the democratic legitimacy and legal power of formal plans/policies with the creativity, energy and social capacity of bottom-up initiatives, entrepreneurship and community involvement. 2ISECAP will develop and apply an innovative holistic approach for participatory and integrated sustainable energy and climate actions planning that considers the required institutional tools, legal frameworks and local initiatives. Emphasis will be given on driving the sustainable energy transition at cities level through the Climate City Contracts. The planning approach will enhance SECAPs visibility and implementation capacity and the development of sustainable relationships between government and civil society. 2ISECAP utilizes the Living Lab (LL) concept to activate participants to co-create knowledge, energy plans and future policies. The project will provide experiential learning to 6 European Municipalities, by applying 2ISECAP approach to revise/develop their SECAPs, within a LL environment. Eight EU Countries are involved in 2ISECAP. Over 100 public officers will enhance their institutional and technical capacity on participatory integrated planning and governance structures engaging civil society on local energy transition. At least 6 institutionalized collaborations between public authorities are expected to derive and about 30 policies to be influenced. In total, more than 1,300 stakeholders will be informed on Integrated SECAP planning and 5,500 citizens will be involved in the project’s activities.

Keywords: institutional capacity,governance structure,energy transition,local energy coalition,public engagement approach,multilevel governance,integrated sustainable energy planning,living lab,secap
Inefficient Decision Making and Female Bargaining Power (FEMPOWER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1470375.0
EU funding (EUR): 1470375.0
Participants: 1
Project status: SIGNED

Dominant economic models of household decision-making assume a utopian scenario characterised by cooperation, commitment, and efficiency. While elegant and tractable, a range of common family behaviours fall outside the scope of these frameworks limiting our understanding of households as economic units and their role in helping individuals insure against shocks. Furthermore, the policy prescriptions implied by the standard models can result in harmful unintended consequences if implemented in contexts where non-cooperative decision-making prevails (Erten and Keskin, 2018; Bobonis et al, 2013). FEMPOWER will make both methodological and substantive contributions to the economic literature on female bargaining power by harnessing novel sources of administrative and survey data and by building on my expertise in developing innovative ways of modelling family decision making. FEMPOWER will develop frameworks for estimating models of decision-making that can capture potentially inefficient behaviour in three different Work Packages: (1) Violence & Household Decision-Making; (2) Decision-Making at Divorce; (3) A General Model of Inefficient Households. Each work package will be structured around three complementary activities: 1. Developing high quality empirical facts about behaviour in these contexts using novel administrative data sources; 2. Deriving the conditions under which new, innovative economic theories of behaviour can be tested and estimated; 3. Estimating the key economic parameters of interest to assess the positive and normative impact of policy proposals. To enable me to exploit existing data sets and identifying variation that are particularly well suited to answering the research questions posed, each Work Package draws on data from a different OECD country: Finland (Work Package I), UK (Work Package II), and Sweden (Work Package III).

Keywords: family economics,intrahousehold allocations,bargaining power,identification