Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The obesity-induced macrophage: a new player in atherosclerosis development (MACOBESITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Obesity is an independent risk factor for atherosclerosis but the exact mechanistic link between these conditions is unknown. Parallel to atherogenesis, obesity induces the recruitment of pro-inflammatory macrophages from bone marrow to adipose tissue (AT). We hypothesize that obesity-induced macrophages, through interactions with adipose tissue-derived free fatty acids, are important players in atherosclerosis development and thereby represent the key link between these conditions. First, we will investigate the effects of obese AT on the phenotype and function of adipose tissue macrophages (ATMs) and the consequences for atherogenesis. Since it is known that obesity leads to recruitment of CD11c-positive, dendritic cell-like ATMs, the effects of local AT-derived free fatty acids (FFAs) on ATM phenotype and their antigen-presenting capacity will be assessed in vitro and in vivo using mouse models. Additionally, we will isolate CD11c-positive and CD11c-negative (resident) ATMs from obese AT and compare them by genome-wide expression analysis and functional studies. Moreover, the effects of ATMs on adaptive immune responses and atherosclerosis will be assessed by transplantation of obese AT to atherosclerosis-prone low-density lipoprotein receptor deficient (ldlr-/-) mice. Second, we will investigate the effects of FFAs on the differentiation of macrophages from bone marrow cells and the consequences for atherosclerosis development. Hereto, we will determine how FFAs affect differentiation of bone marrow cells into macrophages by performing functional characterization. The obtained results will be evaluated in vivo by adoptive transfer of bone marrow-derived macrophages, treated ex vivo with FFAs during their differentiation, to ldlr-/- mice. Atherosclerosis development and alterations in the immune response will be measured in detail. Finally, we will validate the results in human patient material identifying novel diagnostic markers and therapeutic targets.

Keywords: l202 transcriptomics,l101 molecular biology and interactions,l713 medical pathology,l407 cardiovascular diseases,l602 adaptive immunity
Systematic elucidation of the regulatory roles of large non-coding RNAs in the toll-like receptor pathway (TLR-LNCRNAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Dendritic cells (DCs) are a critical component of the innate immune system, as they play a major role in pathogen-sensing, initiation of inflammatory reactions, and activation of cells of the adaptive immune system. DCs express several isoforms of the toll-like receptor (TLR) family and other pattern recognition receptors that interact with molecular structures conserved among many microbial species. These interactions initiate a pathogen-specific tailored signaling- transcriptional response, which activates thousands of genes necessary to alert the adaptive immune system and eliminate the pathogenic threat. One of the key questions is how are these gene programs generated and regulated? Eukaryotic genomes transcribe several types of RNA molecules, ranging from protein-coding mRNA molecules to short non-coding transcripts. Large non-coding RNA (lncRNA) molecules are probably the least studied of all RNA species, and for a long time were considered to be “transcriptional noise”. Recent studies highlight the importance of lncRNA in multiple physiological and pathological responses ranging from embryonic stem cell function to cancer. In this study we would like to investigate the role of lncRNAs and chromatin regulators in coordinating a genetic network that directs the observed dynamic output of TLR-activated pathways. We will use high throughput methods to measure the expression of lncRNA in dendritic cells, activated by pathogen components. We will validate the functional roles of these lncRNA using RNAi and asses their mechanistic role in the TLR pathway by elucidating the physical association between these lncRNAs and chromatin regulators. This will allow us to illuminate the roles lncRNAs play in pathogen sensing in mammals.

Keywords: dendritic cells,non-coding rna,toll-like receptors
Genetics and epigenetics of animal welfare (GENEWELL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Sweden
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-03-01
End date: 2018-02-28
Duration (months): 60.0
Total project cost (EUR): 2499827.77
EU funding (EUR): 2499827.77
Participants: 1
Project status: CLOSED

Animal welfare is a topic of highest societal and scientific priority. Here, I propose to use genomic and epigenetic tools to provide a new perspective on the biology of animal welfare. This will reveal mechanisms involved in modulating stress responses. Groundbreaking aspects include new insights into how environmental conditions shape the orchestration of the genome by means of epigenetic mechanisms, and how this in turn modulates coping patterns of animals. The flexible epigenome comprises the interface between the environment and the genome. It is involved in both short- and long-term, including transgenerational, adaptations of animals. Hence, populations may adapt to environmental conditions over generations, using epigenetic mechanisms. The project will primarily be based on chickens, but will also be extended to a novel species, the dog. We will generate congenic chicken strains, where interesting alleles and epialleles will be fixed against a common background of either RJF or domestic genotypes. In these, we will apply a broad phenotyping strategy, to characterize the effects on different welfare relevant behaviors. Furthermore, we will characterize how environmental stress affects the epigenome of birds, and tissue samples from more than 500 birds from an intercross between RJF and White Leghorn layers will be used to perform an extensive meth-QTL-analysis. This will reveal environmental and genetic mechanisms affecting gene-specific methylation. The dog is another highly interesting species in the context of behavior genetics, because of its high inter-breed variation in behavior, and its compact and sequenced genome. We will set up a large-scale F2-intercross experiment and phenotype about 400 dogs in standardized behavioral tests. All individuals will be genotyped on about 1000 genetic markers, and this will be used for performing an extensive QTL-analysis in order to find new loci and alleles associated with personalities and coping patterns.

Keywords: animal welfare stress coping personality domestication
Extreme Events Variability over Europe (EVE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project aims at the investigation and analysis of causes for synoptic- to decadal scale variability in the occurrence of meteorological and climatological extreme events over the North-Atlantic/ European region. Focus of the study will thus be to increase the understanding of variability steering factors and to enable a deeper understanding of processes involved in modulating the frequency and intensity of extreme events on the time scales from days up to 30 years and beyond. This understanding should help to allow estimates of necessary adaptation strategies to anthropogenic climate change impacts and their timely planning and initialization. Focus will be laid on severe extra-tropical cyclones as the major meteorological hazard to Europe, as well as on hydro-meteorological combined risks like heat waves and droughts. For the time horizon beyond 2040, scenario based simulations will be investigated to deduce estimates on long-term developments. The project will additionally concentrate on the estimation of damage potentials for wind storm and heat waves on different time scales linking the underpinning science to end-user needs.

Keywords: extreme events,natural climate variability,wind storms,cyclones,decadal predictions,seasonal predictability,atmospheric science
Scalable Switching Architectures for Next-Generation Data Center Networks (SCALE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The growing trend in cloud computing is rising the need for building massive data centers capable of holding hundreds to thousands of servers that sustain and support a variety of services (e.g, web-serach, video content hosting and distribution, social networking and large-scale computations). The interconnection network infrastructure of the data center is key to its cost, performance and feasibility. Several data center interconnection architectures exist that are based on a tree structure built of top of rack (ToR) switches interconnected through end of rack (EoR) switches, and these are being connected through core switches. Independent of the interconnection topology of the data center network, high-performance switches and routes are the key building block of its infrastructure and, therefore, the capability of the data center in all its aspects largely depends on the capability of its switches and routers. While high-performance switch design has been studied in the context of data networking and telecom areas, little research has been conducted into designing switching architectures for data center networks. The objective of this research is to explore this relatively untapped area; that is designing switching architectures for data center infrastructure capable of handling the projected growth of data centers. This research will focus on the following themes: 1) Scalable switching architectures for data centers: Design scalable, practical, high-radix switch topologies that have low latency, performance guarantees and low energy consumption. 2) Switch Resource allocation: Propose scheduling and resources allocation algorithms with controllable latencies and guaranteed bandwidth. 3) Flow control: Describe appropriate flow control algorithms to control the flow of packets through the switch stages. 4)Performance evaluation: Evaluation the proposed topologies, algorithms and methodologies algorithms and methodologies for various data center applications.

Keywords: information science,engineering,computer communication networks,date center and network architecture and design
CHEMiRNA: Chemical-based Platforms for micro-RNA Detection. Towards Novel OncomiR Assays (CHEMIRNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Thos proposal present novel reagents and tools for the detection and quantification of microRNAs (miRNAs) with a particular focus on miRNA species involved in solid tumours and hematologic cancers. The proposed project will thus provide a new chemical toolbox which will allow the rapid detection of miRNAs involved in cancers. This proposal intends to take advantage of the novel dynamic chemistry approach to profile directly nucleic acids and develop based on it novel tools to provide simple, sensitive, rapid, multiplexed assays to profile miRNAs. The longer-term vision is that this dynamic chemistry approach will enable clinicians to be able to rapidly and accurately diagnose and prognosis cancer by combining the precision of the high affinity molecular probes and novel set of biomarkers based on miRNAs. Therefore, the proposed project is positioned at the interface of chemistry, biology and pre-clinical medicine with three main aims

Keywords: c114 chemical reactions,c141 organic chemistry,l702 diagnostic tools,l818 biomimetics,v408 biotechnology - bioreactors - applied microbiology,c128 nanomaterials
Tris-heteroleptic cyclometalated iridium(III) complexes for white electroluminescence (HETIRIDIUM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

For economical and ecological reasons, limiting the use of fossil fuel is one of the greatest challenges of our time. Nowadays, about 20% of the European electrical energy is used for lighting and considerable savings could be achieved by developing more efficient lighting systems. Electroluminescent (EL) devices based on organic thin-films are considered as one of the most promising response to the demand for efficient lighting technology. In EL devices, light originates from the radiative relaxation of an excited state localized on a luminescent molecule (the dopant). Due to their suitable photophysical properties, cyclometalated iridium(III) complexes are arguably the most studied family of phosphorescent dopants for OLEDs during the last decade. Organic white light-emitting devices (WOLEDs) are obtained by combining the emission from blue, green and red emitters. Different approaches can be used to mix the emission of the different emitters but they all require complex device architectures, which have a direct impact on the cost of production, greatly hindering their market entry. The aim of the proposal is to develop white light emitting single centered phosphorescent emitters (WSCPEs) to simplify the processing of the devices, resulting on the long term in significant costs reduction. WSCPEs are molecules displaying broad emission covering most of the visible spectrum, this emission originating from a single active center (no excimer, no dual-emission, no double-emission from two active centers). During the project, we will: (1) study tris-heteroleptic iridium(III) phosphorescent complexes of the form [Ir(C^N1)(C^N2)(La)] (C^Nx = bidentate cyclometalated ligand, La = ancillary ligand(s)); (2) determine the electronic and geometric parameters controlling their photophysical and electrochemical properties; (3) exploit this knowledge to prepare efficient single-center broad emitters for white light emitting electroluminescent devices.

Keywords: photochemistry,coordination chemistry,new materials,cyclometalated iridium complexes,electroluminescence,lighting devices
Local Inclusion in Networked Communities - utilising public spaces (LINC-UPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-07-01
End date: 2017-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The main aim of the research Vis to gain knowledge about the links between online social networks and offline public spaces using interdisciplinary empirical methods. The LINC-ups Project will address critical issues within the fields of architecture, urban design, sociology and ubiquitous computing as to how merge the currently disparate worlds of online social networks and offline public spaces to in order to reinforce and strengthen social inclusion at a local neighbourhood level. The LINC-ups project will run over four stages and will be set in the South West regional context of a pioneering roll-out of superfast broadband infrastructure. The first stage will identify a pattern of social connections at neighbourhood places, through analysis of qualitative data from diary studies and interviews with residents in five neighbourhoods. This will establish how people understand and act upon their interactions with technology in their everyday life not just in a purely spatial sense, but more importantly how they are situated within their social networks. The second stage will be an observational study of digital interactions in key public spaces located within the five neighbourhoods which will make it will be possible to understand how public spaces within a neighbourhood are affected. The final empirical stage will draw on results from the first two studies to develop a design-based intervention to directly impact upon the possibility for connecting mediated networks and public spaces. The project will deliver both a theoretical framework and in-depth empirical results on how interaction in social networks enabled by technological infrastructures such as high speed broadband affect social inclusion and overcome digital divides. It will also result in a model for creating high quality public spaces that enable trasnfer between local ties and digital social networks that will impact on planning and policy for regional ICT access and neighbourhood renewal.

Keywords: s113 communication networks - media - information society,s101 social structure - inequalities - social mobility,v106 spatial and regional planning
Jointly Mining User Generated Content Sources (JMUGCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The advent of web 2.0 empowered users to actively interact with the Web instead of passively consuming web content. Today, Web users contribute content to blogs, wiki sites, review portals, and organize themselves into online social networks where they form relationships post their thoughts and activities, and interact with each other. Individuals can now have a “presence” on the web that goes well beyond creating a home page and some documents. This kind of data is a goldmine for scientific research with an unlimited number of practical applications. In this proposed research we are interested in jointly mining user-generated content with other sources of data, in order to enhance our understanding of data, and improve the knowledge extraction process. We consider two settings: jointly mining two different sources of user-generated content, and jointly mining user-generated content with structured data. We propose problems within these two settings, focusing on ranking, and translation of user-generated attributes.

Keywords: g106 informatics and information systems,g102 database management
Smart large lightweight long life Multifunctional PV Module Technology for large Power Installations and Distributed Energy Generation (SUMMIT)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Germany,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Italy,Netherlands,Netherlands,Netherlands
Call:  (FP7-ENERGY-2012-2, 2012)
Start date: 2013-12-01
End date: 2018-05-31
Duration (months): 54.0
Total project cost (EUR): 6372256.4
EU funding (EUR): 3999969.25
Participants: 11
Project status: CLOSED

SuMMiT brings value to Europe by demonstration of large lightweight PV modules with record power output, lowest installation cost, lowest PV system cost and lowest carbon footprint in a secure way, i.e. certified performance, quality and durability, protected by patents and proprietary knowhow. SuMMiT combines and demonstrates three step-change innovations: 1. COSMOS PV module design, i.e. a large lightweight hybrid subassembly structure; 2.Highly efficient, long-lasting, top quality, single glass PV laminate; 3.Smart module power management. The demonstration is twofold. The manufacturability of the novel PV module concept will be demonstrated as well as simplicity of installation and utilization, applicability, performance and durability in 5 to 6 field demonstrations. The consortium brings together the required critical mass in polymer technology and polymer processing, encapsulant technology, smart electronics, world class high performance PV module technology and production capacity as well as one of the Europe’s leading turn-key PV system installation companies with subsidiaries all over the world.

Keywords: large lightweight long life pv module technology,large power installation,distribution energy generation