Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Application of high-sensitive and high-throughput molecular tools to disentangle the mechanisms of heavy metals accumulation and tolerance in mosses: epigenetic and transcriptomic approaches (BRYOMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-08-25
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

The anthropogenic emission of heavy metals (HM) into the atmosphere constitutes a major social and environmental concern. Poor air quality is a major health risk (in 2010, more than 420,000 people were estimated to have died prematurely from air pollution in the EU) and has also considerable economic and environmental impacts, affecting the quality of fresh water, soil, and ecosystems [http://ec.europa.eu/environment/pubs/pdf/factsheets/air/en.pdf]. Though several regulatory steps have been implemented within the EU to reduce or restrict the release of pollutants in the air, e.g. [Council Directive 96/62/EC], and also to monitor/model them [Council Directive 2004/107/EC], more work is needed to progress in the characterization of the relationship between living organisms and environmental pollution. Therefore, BRY“O”MICS will provide a deep understanding of the mechanisms underlying the existence of phenotypic variability for heavy metals tolerance and hyperaccumulation in mosses (which differ from those in higher plants), as well as the necessary background knowledge to subsequently develop high potential biotechnological tools for air quality remediation (focusing mainly in urban and indoor environments). This will be achieved by means of the integrated use of various tools from several biological disciplines such as ecophysiology, chemistry, microscopy, transcriptomics, epigenomics and bioinformatics. The most innovative part of this project lies in the application of the “omics” technologies to a novel and under-researched context: wild populations of terrestrial mosses growing in heavy metal enriched areas. Additionally, the integration of the results obtained from the former disciplines will highly improve the conclusions achieved with this project.

Keywords: bryophytes,terrestrial mosses,heavy metal pollution,local adaptation,plant evolution,response to environmental changes
CHallenges in ANalysis and GEometry, between mean and scalar curvature (CHANGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy,Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1342500.0
EU funding (EUR): 955000.0
Participants: 2
Project status: SIGNED

The interplay between Analysis and Geometry has led to a number of spectacular achievements such as the proof of the Poincaré conjecture by Perelman. The goal of this proposal is to establish a research group that will make striking progress along the following two directions, that reflect the two souls, extrinsic and intrinsic, of Riemannian Geometry, as well as their mutual interaction. Minimal surfaces, namely surfaces of zero mean curvature, have been an object of mathematical study since the 18th century (with pioneering work by Lagrange and Euler), and yet remain at the heart of many problems to this day. I aim at shading new light on their understanding, by means of a thorough investigation of the Morse index as an observable on the space of minimal cycles, both in general 3-manifolds of positive curvature and in space forms, towards higher Urbano-type theorems and beyond min-max techniques. Partly motivated by the study of data sets for the Einstein equations on the one hand, and by a far-reaching program by Gromov on the other, we also want to systematically study the interplay between the scalar curvature of a manifold and the mean curvature of its boundary. The project, which builds on my recent contributions and long-term experience in the field, relies on a combination of diverse elliptic and parabolic techniques, and aims at developing effective deformation methods that will have a variety of applications. These directions, while seemingly different, are deeply intertwined both at the technical and conceptual level, and incarnate the primary goal of redefining the state of the art in the investigation of infinite-dimensional spaces of solutions to fundamental geometric problems.

Keywords: minimal surfaces,morse index,positive scalar curvature,geometric variational problems
Continuous Regional Analysis Device for neonate Lung (CRADL)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Cyprus,Switzerland,Sweden,Switzerland,Netherlands,United Kingdom,United Kingdom
Call: Establishing effectiveness of health care interventions in the paediatric population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-06-30
Duration (months): 42.0
Total project cost (EUR): 5537142.5
EU funding (EUR): 4234330.0
Participants: 12
Project status: CLOSED

Each year 15 million babies are born prematurely and many suffer from respiratory failure due to immaturity of the lung and lack of control of breathing. Although respiratory support, especially mechanical ventilation, can improve their survival, it also causes severe injury to the vulnerable lung resulting in severe and chronic pulmonary morbidity lasting in to adulthood. Heterogeneity of lung aeration, resulting in areas of lung over inflation and lung collapse, plays a crucial part in the risk of mortality and morbidity due to respiratory failure. This distribution of lung aeration cannot be detected by currently available bedside monitoring tools and imaging methods. Thus, an imaging technique for continuous non-invasive bedside monitoring of infants lung function is urgently needed. In order to address this, CRADL will use EIT technology to establish a monitoring tool for interventions in the paediatric population. Electrical impedance tomography (EIT) is a non-radiative, inexpensive technique that can facilitate real time dynamic monitoring of lung aeration, and recent studies have shown that it is effective in monitoring aeration in preterm babies. CRADL will show how EIT can provide new cost effective, easy to use, respiratory management tools and clinical protocols that can be universally adopted to reduce deaths and disability in preterm babies by delivering a tool that provides continuous, non-invasive, radiation free, bedside information on regional lung aeration and ventilation during daily clinical care of (preterm) infants and children with respiratory failure. CRADL will also assess the effectiveness, efficacy and safety of such a system in guiding respiratory management and supportive care of the most common causes of paediatric respiratory failure (respiratory distress syndrome, bronchiolitis and acute respiratory distress syndrome), with the final goal of reducing short and long term adverse effects of disease and its treatment in this populat

Keywords: lung ventilation,neonates paediatrics,electrical impedance tomography,wearable imaging,positive end expiratory pressures peep,non invasive
HIV/SIV exploits DCs in mucosal infection: mechanisms of transmission and modulation by semen associated factors (DCmucoHIV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Worldwide a large proportion of all new cases of HIV-1 infection are due to anal sexual intercourse, being the anal/rectal as well as distal colonic mucosa a site of viral uptake and entry. I recently demonstrated that intestinal lamina propria resident DCs migrate towards and extend cellular processes between the tight junctions of columnar epithelium through a CCR5-dependent mechanism, take up R5 but not X4 HIV-1, and then transfer infection to susceptible T cells. Although in mice CX3CR1+DCs are deputed to shuttle microbial antigens, there is no clear idea on which subsets of DCs are located in the human GI tract, are involved in HIV infection and contribute to virus spread, its presentation or possibly to its reservoir. Moreover, the ability of DCs to shuttle the virus across the mucosa may be largely modulated by components of semen, the natural vehicle of HIV during sexual transmission. To fill these gaps I propose a comparative study in macaques and humans using a multidisciplinary approach, which will unravel the mechanism associated with rectal transmission of HIV/SIV by DCs and their modulation by semen. Specific objectives will be: 1. Define the subsets of DCs and the molecular mechanism(s) through which DCs directly sample HIV-1/SIV through the intestinal epithelium and facilitate the spread of the infection. 2. Define the impact of semen on HIV/SIV-induced DCs migration across the epithelium. 3. Determine the ability of lamina propria DCs subsets to migrate across the intestinal epithelium and to redistribute to draining lymph-nodes following in vivo exposure of Cynomolgus macaques to infectious pathogenic SIV. We expect to characterize the early events of DC-mediated intestinal transmission of HIV/SIV and thus contribute to the knowledge base needed to identify, evaluate and develop novel agents or strategies to prevent mucosal HIV transmission

Keywords: dendritic cells,mucosal transmission,semen
Multi object spectrometer with an array of superconducting integrated circuits (MOSAIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 2400894.0
EU funding (EUR): 2400894.0
Participants: 2
Project status: CLOSED

Recent sub-millimeter instruments on the Herschel Space Observatory, operational from 2009-2013, have discovered thousands of sub-millimeter galaxies, whose combined emission forms the cosmic infrared background. A major challenge is to measure their distance, or age, by determining their redshifts, which also has to be based on the sub-millimeter signals (because they do not have an optical counterpart). I propose to develop a new redshift survey instrument, using recent progress in superconducting nanotechnology, which can spectrally resolve a large fraction of the cosmic infrared background from the ground. The instrument is a Multi-Object Spectrometer with an Array of superconducting Integrated Circuits. It consists of a 3D integrated field spectrograph with a 2D array of 25 pixels sparsely filling the re-imaged focal plane of the observatory. For each pixel the instrument measures the radiation spectrum in a 325-905 GHz window with a resolution R=F/δF=500. Additionally the beam of each pixel can be steered electrically to lock onto an individual astronomical object. This allows fast, high accuracy redshift determination of 25 objects simultaneously by measuring the frequency shift of the CII and CO lines. I will develop the instrument, build it, install it on the 10 m Japanese ASTE observatory in Chile and facilitate its use. MOSAIC will be fully based on novel superconducting circuits: a broad-band antenna with electrical beam steering and an on-chip spectrometer, combined on a single chip. The design of the instrument is based on recent developments in superconducting nanotechnology, for signals in the GHz to THz range, in which I am currently playing a leading role. The instrument will be developed with a team of experts in the fields of antennas, spectrometer and readout electronics.
IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION (HISTO-MRI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Netherlands,Denmark
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-03-31
Duration (months): 51.0
Total project cost (EUR): 3216250.0
EU funding (EUR): 3216250.0
Participants: 5
Project status: CLOSED

The main objective of HISTO-MRI project is to develop the technologies that will enable the non-invasive visualization of individual human cells in vivo and in real time, based on a radical new Magnetic Resonance Imaging concept: High Frequency Pulsed MRI. To accomplish this ambitious objective, several new challenging multidisciplinary technologies will have to be developed: 1) new method for the production of magnet coils, based on additive manufacturing technology, in order to stand very high currents at very high frequencies; 2) novel high frequency high voltage pulse power sources, based of semiconductor switches, to feed those magnet coils; and new pulse sequencing and computer algorithms to deal with and analyse the enormous amount of data. Therefore, this project has a foundational character, establishing the basis for a new field of research, pulsed MRI in the high frequency regime, which will radically advance MRI performance to micron resolution. A Proof of Concept of the new technology will be accomplished through the visualization of a mouse brain at the neuron level. This new technology will enable transformative research in the fields of neurosciences, bioengineering, biophysics and experimental oncology

Keywords: prepolarized mri,in vivo imaging,micron resolution,strong pulsed magnetic field,ultra fast,gradient coils,additive manufacturing
Climate cHange mitigAtioN poliCies and Equality: distributional implications for different socio-economic groups (CHANCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-13
End date: 2022-01-12
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

The overarching goal of CHANCE is to contribute to bridging the gap between economic and social goals, through enhancing our understanding of how to foster socially fair and economically efficient climate mitigation policies. CHANCE will be implemented through a novel approach integrating Computable General Equilibrium and Microsimulation models. The specific research objectives of this project have not been addressed in the past. In this sense, the project will contribute to enhance EU scientific excellence by consolidating novel multidisciplinary research. CHANCE will reduce this gap in the literature through two specific relevant multi-regional case studies in settings where climate, energy policies and trade agreements are at the core of the current political debate: first, relations between Mexico and the USA (outgoing phase) and second, relations within the 28 Member States of the European Union (return phase). Through these analysis, identifying the factors which induce regressive policies, CHANCE could guide improvements in the design of policies. CHANCE will provide me with training and experience to widen my current expertise and promote my future career as an independent researcher. By the end of CHANCE, I expect to become a highly multidisciplinary researcher in the field of environmental management and decision-making, which will enable me to obtain a permanent position in Europe. Furthermore, the combination of knowledge and experience at MIT (outgoing phase) and at BC3 (return phase), and more specifically, of my supervisors (John Reilly and Mikel Gonzalez-Eguino), will offer me multidisciplinary training, to which I would not otherwise have access. CHANCE is the starting point of an ambitious and broader professional vision to gather the tools and databases necessary to provide policy makers around the world with relevant and accessible information on the global distributional implications of the transition to a low carbon economy.

Keywords: environmental economics,ecological economics,social sciences,inequality,distributional analysis,general equilibrium models,micro economic modelling
AUTOMATIC STRAPPING SYSTEM FOR UPHOLSTERED FURNITURE (AUTOSTRAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Through AUTOSTRAP our company, AEQUS, aims to revolutionize the European furniture market and contribute to boost its growth by exploiting and developing the niche market of upholstered furniture, introducing a full automated strapping solution through a robotic cell. Driven by the needs of European furniture manufacturers based on increasing production and reducing costs to compete with low labour costs countries, AUTOSTRAP is the solution because will multiply production per 9 and will reduce production costs in a 40%. Besides, end-users will be benefited with a better quality and longlasting product that will prolong its lifetime from 10 - 12 years to 20 - 22 years. We want Europe to recover its lost position in furniture production and export with a high-technology solution, that will allow to recover its innovative position worldwide.Our preliminary projections of the market deployment of AUTOSTRAP in 2022 show a Return on Investment, ROI, of 3.44 for the first five years, impliying revenues of € 15.9 million for our company.

Keywords: strapping,automatic,upholstered furniture,artificial vision
DISCOVERER – DISruptive teChnOlogies for VERy low Earth oRbit platforms (DISCOVERER)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Germany,France,United States,United Kingdom,Denmark,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2022-09-30
Duration (months): 69.0
Total project cost (EUR): 5726750.0
EU funding (EUR): 5726750.0
Participants: 9
Project status: SIGNED

We envision a radical redesign of Earth observation platforms for sustained operation at significantly lower altitudes than the current state of the art, using a combination of new aerodynamic materials, aerodynamic control and air-breathing electric propulsion for drag-compensation, for a variety of observation methods with the aim of creating a new platform paradigm. This vision requires foundational research in spacecraft aerodynamic characterization, in material aerodynamics and atomic oxygen resistance, in electric propulsion, and control methods. These activities are by their nature multidisciplinary covering atmospheric science, surface chemistry and material characterization, control engineering, spacecraft design, payload engineering, etc.

Keywords: spacecraft platform,very low earth orbit,spacecraft orbital aerodynamics,air breathing electric,propulsion
HISPOB- High Speed Potato Breeding: securing healthy food for the future (HISPOB)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Netherlands
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 3658750.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The potato is excellently positioned to play a very important role in turning the high demand for resource-efficient and sustainable food production world-wide into an opportunity. The potato is the world’s number one non-grain food commodity, with an annual production reaching 374B kilo. The main current varieties of potato are in cultivation for many years due to the genetic complexity of the potato and inefficient breeding process. Breakthrough in potato breeding will enlarge the potential of potato as a food, feed and industrial crop. Solynta has developed a revolutionary breakthrough in potato breeding by establishing HIgh Speed POtato Breeding (HISPOB). Targeted and predictable breeding has now become possible, enabling the development of new innovative varieties within a time period of 2 years compared to >10 years in traditional breeding, with beneficial traits (like improved disease resistance, 80% less pesticide use and 30% higher yield). Furthermore, thirty grams of seed is sufficient to produce enough seedling tubers to plant one hectare of potatoes whereas 2500 kilos of conventional seed tubers are required for the same area. Thus, the propagation via True Potato Seeds will speed up the process of potato propagation by more than 400% and simultaneously decrease the costs with more than 300%. In this project, Solynta’s HISPOB technology will be completed and qualified for commercialization and a licensing system will be implemented for market introduction. The efficiency and effectiveness of potato breeding will be more than tripled, estimated value added will run between €5B-€10B (yearly) in the next 5-10 years. Solynta’s HISPOB technology will further strengthen the European agri-food sector (Europe is the worldwide acknowledged leader in potato development), limit environmental degradation, reducing post-harvest losses and optimise the development of more resource-efficient food production and processing.

Keywords: potato breeding,resource efficient,sustainable,food production,food security