Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nonequilibrium thermodynamics of the origin of life (NETOLife)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2026-07-31
Duration (months): 38.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

It has long been suggested that the laws of thermodynamics may specify thresholds for the origin of life, in terms of minimal free energy fluxes needed to perform basic life-like functions such as self-maintenance and self-replication. Such thresholds have yet to be derived, however, in large part because conventional thermodynamics is restricted to systems that are in equilibrium, macroscopic in scale, and that do not exchange information with their environments. On the other hand, protobiological systems (minimal systems that lay at the beginning of life) were likely far-from-equilibrium, nanoscale, and exchanged information (e.g., via simple mechanisms of adaptive response such as chemotaxis). Recent times, however, have witnessed a revolution in nonequilibrium thermodynamics, which has produced far-reaching results concerning systems that are far-from-equilibrium, nanoscale, and may exchange information. These results are currently finding various applications in the study of biophysics of modern organisms. While the tools of nonequilibrium thermodynamics are well-suited for analyzing protobiological systems, they have yet to be applied in origin of life research. Instead, most existing models of protobiological systems are highly abstracted and ignore underlying thermodynamics. In addition, existing research in the field has paid very little attention to the role of information exchanges in early life. This project will address these gaps, by using techniques from modern nonequilibrium thermodynamics to study the origin of life. Specifically, it will investigate thermodynamic tradeoffs involved in three essential protobiological functions (self-maintenance, self-replication, and Darwinian evolution), including in systems that exchange information with their environment. This project will shed light on fundamental thermodynamic thresholds, which will have important implications for our theoretical understanding of the origin of life.

Keywords: origin of life,protocells,abiogenesis,theoretical,nonequilibrium,thermodynamics,stochastic thermodynamics,chemical reaction networks,master equations,entropy production
The InteRnatIonal ecosystem for accelerating the transition to Safe-and-Sustainable-by-design materials, products and processes (IRISS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: Sweden,Germany,Austria,Netherlands,Slovenia,Finland,Italy,Portugal,Belgium,Czechia,France,Greece,United Kingdom,Switzerland,Spain
Call: Establishing EU led international community on safe- and sustainable-by-design materials to support embedding sustainability criteria over the life cycle of products and processes (CSA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 3579852.5
EU funding (EUR): 3579850.5
Participants: 21
Project status: CLOSED

The IRISS project aims to connect, synergize and transform the SSbD community in Europe and globally towards a life cycle thinking where there is a holistic integration of safety, climate neutrality, circularity and functionality of materials, products and processes throughout their lifecycle to meet the EU Green Deal, EU Chemicals Strategy for Sustainability, and UN SDGs. The uniqueness of IRISS is that the consortium is built of core and network partners that represent the top components needed to build an EU-led permanent network (i.e. policy, industry, applied science, innovation and research & education), and that is self-sustaining and international in scope. IRISS responds to the work programme with the following objectives: 1. To develop a state-of-the-art SSbD ecosystem that is supportive for the uptake and utilization of safe-by-design (SbD) and sustainable-by-design (SusbD) strategies by industry, especially SMEs. 2. To contribute to criteria and guiding principles for SusbD development driven by the application of life cycle thinking in materials and product design and in line with ongoing work in European and international initiatives. 3. To establish a structure for a permanent, gender balanced, inclusive, international and sustainable experts? network accessible for all relevant stakeholders. 4. To develop SSbD roadmaps encompassing 3 agendas identifying: 1) scientific research needs, 2) skills, competences and education needs, and 3) knowledge and information sharing needs. The roadmaps will be developed in a co-creation and inclusive process for the implementation of SSbD in industry and society including prioritised steps within research, innovation, skill demands, management and governance. 5. To develop a monitoring and evaluation programme that systematically scans for state-of-the-art knowledge, information gaps and translates these into specific R&D questions and governance needs that feed into systematic roadmap updates.

Keywords: ssbd safe and sustainable by design,ssbd ecosystem,climate neutrality,circularity,functionality,zero pollution,non toxic society,advanced materials,nanosafety,chemicals,products,processes
Applying novel single-cell multiomics to elucidate leukaemia cell plasticity in resistance to targeted therapy (SC-Plasticity)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1882440.0
EU funding (EUR): 1882440.0
Participants: 2
Project status: SIGNED

Novel targeted therapies are increasingly applied against a wide range of cancers. Although such agents can induce cures, most patients suffer from relapsed disease. Acute myeloid leukaemia (AML) is a prime example of a deadly disease, but we have a chance to dramatically improve outcomes if we can better understand resistance mechanisms against targeted agents that are transforming AML treatment, such as the BCL2 inhibitor venetoclax. AML is characterised by profound alterations in the epigenome that are correlated with poor survival. I therefore hypothesise that targeted drug pressure induces epigenetic plasticity that allows cancer cells to sample alternate chromatin or transcriptional states, a subset of which confer drug resistance. A major challenge is to define how mutations of epigenetic regulators in AML affect therapy responses due to clonal heterogeneity. To address this challenge, I will use and further develop my recently published single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) method to link the genotype of expressed genes to transcription and methylation profiles of thousands of single cells. In this research proposal, I aim to (1) develop a new method linking epigenetic landscape, genotype and transcriptome at a single-cell level and define the impact of treatment on these interactions. (2) Analyse the genome-wide impact of epigenetic therapies. (3) Define the association between drug sensitivity and epigenetic modifications regulating pro-survival genes. To achieve my goals, I will apply my novel single-cell multiomics to samples from AML patients treated with venetoclax alone or in combination with epigenetic therapies and apply state-of-the-art technologies to established laboratory models. Our new approaches to fully understand the relationship between the genome, epigenome and transcriptome will advance fundamental biology. This has the potential to yield new therapeutic strategies to prevent and overcome resistance.
The Centre of Gravity Project (COGY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1999736.0
EU funding (EUR): 1999736.0
Participants: 1
Project status: SIGNED

The foundations of the general theory of relativity (GR) were laid by Albert Einstein in 1915. But much of what has been built on those foundations was developed in the Renaissance Period of GR between 1955 and 1975. Indeed, without the concepts and tools formed during this Renaissance, the recent observation of gravitational waves, rewarded with the Nobel Prize in physics in 2017, and the convincing prediction of and mounting evidence for the existence of black holes, rewarded with the Nobel Prize in physics in 2020, would not have been possible. At the centre of the Renaissance of GR is Roger Penrose. It was Penrose who developed much of the tool box that made the successes of the Renaissance possible. Penrose was surrounded by and built upon the work of the newly emerging international community of relativists, in particular Hermann Bondi at Cambridge, John Wheeler at Princeton, Jürgen Ehlers at Hamburg, and Stephen Hawking at Cambridge. The Centre of Gravity Project (COGY) will combine pioneering research on the literary estates of the core figures of the Renaissance period, including unique access to the hitherto inaccessible Penrose estate, with the analysis of detailed oral-history interviews. The analysis will be helped by the creation of a novel kind of database that will help cross-correlate the different sources. The aim is to get to the bottom of the most advanced mathematical techniques and conceptual innovations of GR, concepts like black holes and event horizons. In understanding the genesis and subsequent interpretation of these concepts we will also lay the groundwork for understanding the most exciting elements of today's physics: the physics of gravitational waves as they arise from black hole and neutron star mergers, as well as of the supermassive black hole around which our entire galaxy rotates.

Keywords: integrated history and philosophy of science,history of modern physics,history of recent science,general relativity,gravity,mathematical relativity,black holes,gravitational waves,mathematical methods in science
Bringing Excellence to Transformative Socially Engaged Research in Life Sciences through Integrated Digital Centers (BETTER Life)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Germany,Italy,Estonia,Latvia,Poland,Romania,Serbia
Call: Capacity building to strengthen networks of higher education institutions and cooperation with surrounding ecosystems (HORIZON-WIDERA-2021-ACCESS-05, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1871843.75
EU funding (EUR): 1871311.5
Participants: 9
Project status: SIGNED

The project “Bringing Excellence to Transformative Engaged Research in Life Sciences through Integrated Digital Centres - BETTER Life” will establish a European Digital Centre of Excellence for fostering Socially Engaged Research (SER) in Life Sciences, as well as seven regional centres operating in their surrounding ecosystems. This inter-institutional support structure addresses the lack of collaboration between early career researchers and the non-academic sectors by designing tools, standards, and framework conditions under the umbrella of the EU centre and implementing these solutions in the regional ecosystems. The project aims to support the development of inter-institutional capacities by establishing an EU BETTER Life coordination centre that will generate transferable tools and standards. At an intra-institutional level, the project creates local centres guided by a framework to follow the regional customization implementation. At an individual level, the regional centres develop capacities by training early career researchers and establishing a community of practice in each surrounding ecosystem. For that purpose, the centre is based on the quadruple helix model of innovation, where the interaction of academic, research, industry, government, and society generate mutually beneficial partnerships. The most outstanding outcomes of the project will be: • 200+ early career researchers trained • 14+ engagement managers trained • At least 10 standards for SER in Life Sciences • 14+ consultation events with local stakeholders • 40+ open source documents • 6 open science publications • 1 digital self-assessment tool for researchers • 15+ training events In a long term, the project will generate scientific impacts by designing transferable policies and tools, economic impacts by effectively attracting funding, and societal impacts by embedding local ecosystem needs and enhancing the real-life impact of academic institutions.

Keywords: socially engaged research,ecosystem collaboration quadruple helix engagement,early career research,life science,responsible research and innovation,joint governance structures,co creation
Matching innovators with buyers (InnoMatch)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Ireland,Germany,Spain,Estonia
Call: Support to test EIC innovations for public and private procurers (HORIZON-EIC-2023-INNOVPRO-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 2999875.0
EU funding (EUR): 2999875.0
Participants: 4
Project status: SIGNED

Overcoming the challenge of finding initial customers is a significant obstacle for the commercialization of innovative solutions developed by SMEs, particularly EIC awardees (EICs). This challenge is especially pronounced when the target market involves public administration or large private corporations (Buyers). To mitigate these challenges and broaden the scope of innovation procurement in Europe, InnoMatch will facilitate the co-creation and proof-of-concept demonstration of EIC innovations, focusing on addressing the unmet needs of selected buyers. InnoMatch will achieve this by fostering collaboration between EICs and buyers, with a specific focus on ensuring successful solutions are adopted by the buyer following the pilot phase, which may not always be the case. The offered support includes not just the identification of needs and the facilitation of connections between EICs and buyers for pilot deployment, but also strategies to enhance the likelihood of adoption by buyers and accelerate the commercial advancement of EICs. To fulfil this vision, InnoMatch will invest €2.28M in grants to EICs (76% of project budget), supporting 38 pilots which will be distributed through two types of open calls: OC#1: Call for EIC+Buyer: EICs apply together with pre-identified buyer; OC#2 EICs: EICs apply with a solution to a pre-defined challenge, which has been identified by at least 2 separate and independent buyers. The identification of the Buyers challenges will follow a specific methodology which includes a OC#2 Buyers, capacity building, workshops that aim to aggregate individual needs & expectations into a common challenge definition and, ends up with the signature of a sub-grant agreement. The team -F6S, ICLEI, TBM and CIV- 1) has wide network of buyers; 2) worked with EIC community & corporates; 3) experience in FSTP (+€80m, +180 calls & +7k awardees), 4) Innovation Procurement with +10 EU projects in the domain; 5) delivered business & mentorship programmes.
European FOREST Research and Innovation Ecosystem (EUFORE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Research and Innovation actions
Countries involved: Finland,Germany,Denmark,France,Slovakia,Belgium,Spain,Croatia,Italy,Austria
Call: Strengthening the European forest-based research and innovation ecosystem (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 3996391.25
EU funding (EUR): 3996390.0
Participants: 16
Project status: SIGNED

The EUFORE project supports the preparation for a possible European research and innovation partnership on forests under the Horizon Europe Programme. It aims to develop a sustainable, transnational, co-creative environment to define, implement and evaluate research and innovation (R&I) agendas and roadmaps for the entire forest-based value chains in Europe. The project will assess and outline research needs, and provide a platform for increased R&I cooperation, coordination and joint funding for forestry and the forest-based sector, thus supporting the implementation of the new EU forest strategy. EUFORE outputs include a strategic R&I agenda for forestry and the forest-based sector (SRIA), along with accompanying implementation measures and stakeholder commitments. These will be co-designed with key relevant actors, in a multi-actor approach. The project team will facilitate and strive to implement broad stakeholder engagement via diverse participation mechanisms, all designed to instil a sense of co-ownership of the SRIA preparation process and thus secure support for its implementation. To enable its stakeholders to reach informed decisions, EUFORE will provide them with all the relevant information that is needed, in formats suitable for a wide range of audiences. This will entail: a review of European R&I activity in the sector, funding and governance; information on societal expectations towards the sector; analysis of the policy environment and its R&I implications; and foresight on how the sector might develop, and what the future supply of and demand for its ecosystem services and products may be.

Keywords: strategic planning,randi funding,co design,partnership,multi actor,forest based
NEST InGrained ecosystem foR zEro EmissioN buildings (GreeNest)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Greece,Germany,Italy,Poland,Spain,Luxembourg,Lithuania,Czechia,Switzerland
Call: Innovative cost-efficient solutions for zero-emission buildings (HORIZON-CL5-2023-D4-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6472327.07
EU funding (EUR): 4996642.01
Participants: 20
Project status: SIGNED

Reduction of embodied emissions is crucial for achieving sustainable and low-carbon building practices. GreeNest creates an ecosystem that integrates CO2 neutral building materials (reused, recycled and locally sourced biogenic materials) and renewable energy sources (abiotic components) into the building design, together with human response and natural/green systems (biotic components) to demonstrate resource efficient construction that needs less materials and implements energy-efficient circular construction practices. The project targets 100% carbon free construction through the application of biogenic materials that store carbon, the reduction of embodied emissions by 50% with respect to NZEB standard, ZEB or even positive energy standards via renewable energy sources with remaining primary energy consumption less than 30-40 kWh/m2, reduction of GHG emissions by 60% and increased productivity of construction by >30%. GreeNest delivers a palette of innovative solutions for new buildings, addressing all stages of the building’s life, from the design stage up to the end of the building’s lifetime and disposal stages (including re-use and recycling of components). It proposes sustainable envelope components based on low carbon and carbon-neutral market mature materials, using on-site renewable energy, reducing waste, enhancing productivity of construction through digitization and demonstrating circular economy principles. The innovative solutions will be fully demonstrated in four real and two virtual new construction projects in five countries using local and regional value chains increasing the potential for replication across Europe. The GreeNest consortium benefits from a strong industrial and commercial involvement with 11 SMEs 1 Large Company 3 Universities, 3 Associations and 2 Public bodies from 8 European countries.

Keywords: circular materials,biogenic materials,res,envelop components,control,iotand digital tools,design and construction schemes,demonstration,lca lcc,building emissions,iaq,social acceptance