Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Morphology of Lithic Artifacts: Experimental and Morphometric Approaches (MORPHOLITHEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2021-08-08
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

MORPHOLITHEX addresses one of the major research questions in prehistoric stone tool technologies - what are the crucial variables that knappers control to determine the form of their stone artifacts? Specifically, the project investigates the effects of variables that are under the direct control of the knapper, namely various platform management strategies and the morphology of the core surface, on the size and shape of the product. The project uses a novel combination of methods: the knapping process is simulated in an experimental setting that uses an apparatus that enables independent variables to be controlled and measured to isolate their effects on the final results; three-dimensional geometric morphometric methods are used to explore the size and shape of the blanks produced by the experiment; and advanced statistical modeling is used correlate the experimental predictors to the shape and size of the resulting blanks. The specific concentration is on platform management and core surface morphologies common in Levallois blank production, a technology that is present across the Old World during the last 300 thousand years, and is common during the rise and expansion of modern humans around 50 thousand years ago. The goal is to construct a more comprehensive model to account for morphological variation in stone tools and to validate this model using replicative and archeological collections. This quantitatively driven research integrates several of the most advanced approaches in our field and aims to significantly contribute to our understanding of the elementary principles of producing stone tools in prehistory. It further intends to make methodological advancements in controlled experiments for investigating the production of stone tools, as well as developing protocols for analyzing stone tool shape and size with geometric morphometrics.

Keywords: lithic technology,experimental flintknapping,palaeolithic,3d geometric morphometrics
Networked Labs for Training in Sciences and Technologies for Information and Communication (NEWTON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Italy,Ireland,Italy,Romania,Slovakia,Czechia,United Kingdom,United Kingdom
Call: Technologies for better human learning and teaching (H2020-ICT-2015, 2015)
Start date: 2016-03-01
End date: 2019-08-31
Duration (months): 42.0
Total project cost (EUR): 6425191.79
EU funding (EUR): 5618771.75
Participants: 14
Project status: CLOSED

NEWTON is a large scale initiative to develop, integrate and disseminate innovative technology-enhanced learning (TEL) methods and tools, to create new or inter-connect existing state-of-the art teaching labs and to build a pan-European learning network platform that supports fast dissemination of learning content to a wide audience in a ubiquitous manner. NEWTON focuses on employing novel technologies in order to increase learner quality of experience, improve learning process and increase learning outcome. The NEWTON project goals are to: 1) develop and deploy a set of new TEL mechanisms involving multi-modal and multi-sensorial media distribution. 2) develop, integrate, deploy and disseminate state of the art technology-enhanced teaching methodologies including augmented reality, gamification and self-directed learning addressed to users from secondary and vocational schools, third level and further education, including students with physical disabilities, 3) build a large platform that links all stakeholders in education, enables content reuse, supports generation of new content, increases content exchange in diverse forms, develops and disseminates new teaching scenarios, and encourages new innovative businesses. 4) perform personalisation and adaptation for content, delivery and presentation in order to increase learner quality of experience and to improve learning process, and 5) validate the platform impact and the effectiveness of the teaching scenarios in terms of user satisfaction, improvement of the learning and teaching experience, etc. and the underlying technology through an European-wide real-life pilot with 4 different scenarios. The real-life validation will involve all major stakeholders in TEL area, from content providers, innovative idea creators, technology developers, regulators, associations, schools and teachers in a large-scale pilot covering 26 institutions (14 funded from the NEWTON project + 12 a partners) in 7 European countries.

Keywords: large scale tel platform,multi modal adaptive and personalised multi sensorial content delivery,augmented reality,gamification and self directed learning,normal and physical disability learners
Development of Advanced Functional Absorbent Products (DAFAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

DAFAP overall innovation project aims at improve the performance of feminine hygiene items (sanitary pads, tampons and pantyliners) by adding specific elements with important preventive and/or therapeutic properties. To achieve this, it should be necessary to have advanced manufacturing and industrialization processes that allow COHITECH to benefit from this business opportunity. DAFAP will introduce to the market a natural and ecological choice for their intimate hygiene. These new products will be competing against the conventional products, made with viscose, petroleum-based polymers and chemical additives, which can cause dangerous risks to the women who use them (as irritation, itching allergies or other more dangerous damages). DAFAP will be based on 100 % hypoallergenic and ecological pure cotton, and also will present functional features (Smell neutralization, Antimicrobial properties...). The goal of the overall project is to transform the prototype solution which is currently in a TRL6 development stage to TRL9 market commercial product by the end of Phase 2. Hence, COHITECH needs to develop a sustainable and efficient process to use this eco-friendly material, improving an internal technology, to produce a very complete range of products with strong benefits for women. These products will be sold released in international markets. The current feasibility study will analyse how to progress to a commercial profitable product. To do that, DAFAP will analyse the feasibility (at technical, economic and operational levels) of the development and define the reference Business Plan. COHITECH is a high innovative company with proven track record within the field of woman hygiene and health, and with enough experience and ambition to turn the innovation of DAFAP into a sustainable business, covering the whole world.

Keywords: absorbent,feminine hygiene,functional,industrialization,hypoallergenic,eco friendly
Charting Impact Pathways of Investment in Research Infrastructures (RI Impact Pathways)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Germany,Germany,Germany,Italy,Switzerland,Belgium,France
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-06-30
Duration (months): 30.0
Total project cost (EUR): 1498717.5
EU funding (EUR): 1498717.5
Participants: 8
Project status: CLOSED

The aim of the project is to develop a model describing the socio-economic impact of research infrastructures and of their related financial investments. The model will be developed in a modular manner adapting it to a broad range of scientific domains and types of infrastructures. The project outcomes are expected to contribute to a common approach at international level and facilitate investments in research infrastructures by funding agencies and other stakeholders. The project activities will take into account the work of the Research Infrastructure Socio-Economic Impact Working group, being established by the OECD Global Science Forum, and involve major key international players in this domain. More specifically RI Impact Pathways project plans to carry out a comprehensive stocktaking exercise on the existing approaches for impact assessment of research infrastructures and map the current and future data gathering needs of the key stakeholder groups. The goal is to identify the strengths and limitations of the existing approaches, detect existing gaps and overlaps, as well as to assess the level of complexity of the developed conceptual advances. Further, a set of activities will be devoted to map the needs of various stakeholders associated with IA of RIs. Employing participatory and systems thinking approaches the project will develop a modular impact assessment model that represents all major impact pathways of distinct types of research infrastructures. The IA model will be put to practice by defining a set of reference indicators, providing guidance on the most appropriate monitoring and evaluation approaches and testing its feasibility with pilot research infrastructures. The outcomes of the project will be a methodological handbook and an interactive web-based tool that will facilitate more user-friendly navigation in the prepared guidance material.

Keywords: research infrastructures,socio economic impact,impact pathways,pilot study,online assessment
Neural circuits for optimal prediction of timing (PredOpt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Predicting the timing of events is not only crucial to our survival but seamlessly contributes to everyday activities like riding bicycles, dancing or playing sports. Human and animal prediction of timing is statistically optimal, however, how such behavior arises from neural circuitry is poorly understood. Here I outline a theoretical framework, testable hypotheses and a set of experiments that will help uncover the neural circuits that integrate previous experience to make optimal estimates about the timing of events. In this proposal, the systematic investigation of optimality in complex forms of timing behavior is based on exploiting known neural circuits belonging to simple timing behavior. The anatomical origins of simple timing tasks like eyeblink conditioning are extremely well-characterized in the cerebellum of different species. Using this, I propose a framework for extending this circuit to understand optimal timing in a series of targeted physiology, behavior and optogenetics experiments. This research, if successful, will reveal the neural basis for how the nervous system combines previously encountered stimuli and recent observations to generate statistically optimal estimates and will generate valuable insights into the underpinnings of biological intelligence.

Keywords: cerebellum,time perception,eyeblink conditioning,optimal prediction
hiGh-Resolution imAging of the barrel CortEx through VSD and LFP recordings (GRACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Japan
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-06-01
End date: 2021-08-31
Duration (months): 27.0
Total project cost (EUR): 195728.85
EU funding (EUR): 195728.85
Participants: 2
Project status: CLOSED

The aim of this action is to develop an innovative and advanced dual approach to study the barrel cortex, combining Voltage Sensitive Dye (VSD) imaging and high-resolution electrical recordings. The barrel cortex in rodents is part of the primary somatosensory cortex and a well-known example of topographic mapping, where each whisker is mapped onto a specific cortical area, called a barrel. Thanks to its unique functional organization, this system offers excellent conditions to investigate neural mechanisms mediating sensory coding, processing and plasticity. Sensory-evoked activity in the neocortex is known to manifest in the form of propagating waves but up to now there are no studies directed towards a high-resolution mapping of these waves in the barrel cortex in vivo. Thanks to the chronic cranial window designed by Dr. Kuhn at OIST, VSD imaging will be performed simultaneously with high-resolution electrical mapping of Local Field Potentials (LFP) through CMOS-based implantable neural probes developed within an EU project coordinated by UNIPD. Once fully established, this dual method will be transferred to UNIPD and will allow the study of neuronal signal propagation through a 3D architecture in living tissue with simultaneous high-resolution optical and electrical recordings. This action will increase my competences in neurophysiology and promote a close collaboration and a two-way transfer of scientific knowledge between Padova and Okinawa, enhancing the scientific relations between the European Research Area and Japan. This project will contribute to the development of advanced neuroprostheses allowing a bi-directional communication with brain microcircuits through high-resolution LFP recordings and patterned electrical stimulation of neural populations. Moreover, the results of my research will have a strong impact on basic neuroscience of population coding, providing novel insights on the propagation of sensory information within the barrel cortex.

Keywords: brain computer interface,neural probes,barrel,cortex
European Researchers' Night in Sweden - ForskarFredag 2018-2019 (FF18_19)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Sweden
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-04-01
End date: 2019-11-30
Duration (months): 20.0
Total project cost (EUR): 1058964.25
EU funding (EUR): 184000.0
Participants: 1
Project status: CLOSED

ForskarFredag, FF (Researchers' Friday) will unite events in 25 cities and towns in 2018 and 2019 respectively. The project will bring the general public, with a special focus on pupils aged 12–19, face-to-face with researchers through fun, festive and hands-on activities, all free of charge. By reaching out to all corners of Sweden, people will discover local and regional research in a national and international context. The non-profit association VA has coordinated FF annually since 2006, and FF18_19 builds on the success of previous years, drawing on experience, contacts and the ever-increasing national profile. Event programmes will be planned and executed by local subcontractors in centrally located venues and brought together under the national FF umbrella by VA. Subcontractors are universities, science centres, municipalities, museums, research centres and a county council. Each local event is organised in a way to give the highest impact in the local community, building on local strengths and using local networks. The local organisers share experiences and learnings in a national contact network. VA is responsible for the quality, framework, national identity and national awareness campaign. Annual themes – the European year of cultural heritage in 2018 and "50 years since the moon landing" in 2019 – will inspire innovative local activities with the researcher in focus, connect the local activities and strengthen the national profile. Common activities include the high-profile communications contest Researchers’ Grand Prix, Borrow-a-Researcher for schools and Science Cafés. Two annual massexperiments, inviting pupils to work together with researchers, will be conducted nationally as part of the awareness campaign. Collaboration and synergies with other ERN projects on the awareness campaign, activities and impact assessment will highlight the European dimension. FF:s motto is: "Researchers are ordinary people with extraordinary jobs!"

Keywords: science communication,public engagement,people recognition,promotion of science careers,research,science,local industry,citizen science,science festival,hands on activities,general public
Commercialisation of the Connected Enteral Feeding Healthcare System for Integrated & Co-ordinated Care (Mobility+) (MobilityPlus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-05-01
End date: 2022-10-31
Duration (months): 30.0
Total project cost (EUR): 2292875.0
EU funding (EUR): 1605012.5
Participants: 1
Project status: CLOSED

Mobility+ is the future of the enteral feeding healthcare. It is a solution that alleviates the burden on healthcare and addresses specific feeding needs of patients with Complex Chronic Conditions (CCCs). Mobility+ system will be enabled by major advances in wireless technology, miniaturisation, nano-sensors and computing power, enabling the development of a connected medical device for enteral feeding care that can generate, collect, analyse and transmit data. The data, along with the Mobility+ devices themselves, are creating the Internet of Medical Things (IoMT) – a connected infrastructure of medical devices, software applications and health systems and services. This connectivity between Mobility+ sensors and devices will enable healthcare organisations to streamline their clinical operations and workflow management, and improve patient care, even from remote locations. It will disrupt existing business models of how enteral feed is sold and distributed. Due to elimination of hardware (external pump, batteries & other paraphernalia), simplicity of use, reduced maintenance and improved monitoring, Mobility+ will lower enteral feeding healthcare costs by up to 60%. It will provide significantly enhanced benefits to the user (patient) in terms of increased mobility and feeding efficiency - leading to radically improved quality of life. It will be the first and only solution that will provide enhanced usage control options and e-connectivity: enabling effective self-monitoring, better quality of care and improved diagnosis of side-effects. Mobility+ has already gained traction with target customers and end-users in US and Europe and Key Influencers.

Keywords: integrated healthcare,real world data,enteral feeding,tube feeding,medical device,medical nutrition
Structural Vaccinology in the design of bionanoparticles with multi-copy antigen display for vaccines with enhanced efficacy (SVNanoVax)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-15
End date: 2017-06-14
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Vaccines are the most effective way to protect humans from infectious disease and may save over 2 million lives per year (Delany, 2013). A key issue for future vaccines is how to improve immunogenicity without reducing safety (Bachmann, 2010). Another challenge is that high antigen sequence variability enables pathogens to escape the host response. To overcome these challenges, this proposal combines Structural Vaccinology and bionanoparticle (BNP) design, to generate novel self-assembling BNPs with multi-copy antigen display for the development of safe vaccine antigens with enhanced immunogenicity and breadth of coverage. We will generate antigen-BNPs for a 2nd generation vaccine against Neisseria meningitidis serogroup B (MenB), a major cause of sepsis and invasive disease (Pace, 2012). This research may also potentiate antigen-BNP technology suitable for other vaccines. Firstly, we will use functional (bactericidal) monoclonal antibodies to map the most protective epitopes on the 3D structures of two key MenB antigens, fHbp and NadA, which contribute strongly to our recently-approved 1st generation MenB vaccine, Bexsero (O’Ryan, 2014). To aid this, we have developed wide expertise in structure-focused epitope mapping (Malito, 2013). Secondly, we will design optimized antigens stably displaying the best epitopes, an approach that we have pioneered and termed ‘Structural Vaccinology’ (Scarselli, 2011). Finally, self-assembling protein bionanoparticles displaying ordered arrays of the optimized antigens will be prepared, in order to generate novel highly-immunogenic, broadly-protective MenB vaccine candidates. The proposal offers an exciting career development opportunity encompassing novel high-quality research to combine and deliver the promises of Structural Vaccinology and nanobiology, with a high probability of success to generate innovative new vaccine antigens for products to protect humans against meningococcal and other infectious diseases.

Keywords: healthcare,pathogen,meningococcus,vaccine,structural vaccinology,nanoparticles,bio nanoparticles,protein engineering,antigen design,molecular biology,antibody antigen interaction