Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrating National Research Agendas on Solar Heat for Industrial Processes (INSHIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: New knowledge and technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Italy,Austria,Germany,Spain,Spain,Spain,Spain,Italy,Italy,Spain,Germany,Cyprus,Belgium,Switzerland,Türkiye,Greece,France,United Kingdom,Portugal,Portugal,Portugal
Call: European Common Research and Innovation Agendas (ECRIAs) in support of the implementation of the SET Action Plan (H2020-LCE-2016-ERA, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 2858798.75
EU funding (EUR): 2498661.25
Participants: 29
Project status: CLOSED

Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of today’s technology development stage – economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.

Keywords: solar process heat,durability,reliability,solar driven processes to ei sectors,centralized networks in industrial parks,integration in the energy system,mobility,access randd infrastructures
A fast, cost-effective breath analysis technology for Helicobacter pYlori screening at both large and small scale. (HYscreen)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The increasing incidence of Helicobacter (H.) pylori infections and their close link with gastric cancer, gastric lymphoma, duodenal and gastric ulceration, give impetus to the H. pylori diagnostics market. Existing solutions are too costly, inconvenient and invasive; have a long analysis time or need technical expertise to analyse. Bedfont Scientific Ltd offers a portable H. pylori diagnostic device, HYscreen, which detects ammonia in exhaled air as a biomarker for H. pylori. It has a rapid diagnosis, higher accuracy, lower cost, greater simplicity and convenience. It has the following innovation features: a mouthpiece breath entrapment sampling system, a thermal oxidizer and a Nitrogen Oxide (NO) sensor. This solution is aimed at primary and secondary care in Europe and USA and population screening programs in Asia, answering the call for a cheaper, quicker and simpler monitoring device. This will lead to improved clinical decisions that will facilitate early treatment of the infection, preventing H pylori related cases of gastric cancer and gastric or duodenal ulcers. Consequently, Europe-wide and global savings of up to €1.5 billion and €5.66 billion respectively will be realized by avoiding unnecessary endoscopies, biopsies, expensive H. pylori tests and the healthcare bill from H. pylori-related conditions. Ultimately, HYscreen will open doors for fast and affordable population wide screening. The test will use cheaper C12 urea, though work still needs to be done to make it commercially available. There is a challenge to shorten the thermal oxidizer system for better aesthetics and to reduce ammonia absorption. In Phase 1, we study the feasibility of optimizing the thermal oxidizer system, the use and optimization of C12 urea, protection of the product and the detailed business plan. Phase 2 will produce the final product from the prototype along with the validation steps and clinical trials.

Keywords: pylori diagnostics,ammonia,helicobacter,biomarkers
Implementing gender equality plans to unlock research potential of RPOs and RFOs in Europe (ATHENA)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Spain,Spain,Italy,Bulgaria,Poland,Romania,Slovakia,Slovenia,Portugal
Call: Supporting research organisations to implement gender equality plans (H2020-SwafS-2020-1, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 1828310.0
EU funding (EUR): 1828310.0
Participants: 10
Project status: SIGNED

One of the main objectives of Europe’s societies is the elimination of all types of discrimination associated with gender. Despite a high number of highly skilled female graduates, there is still very few of them embracing a research career. With almost 60% of women graduates in EU, only one third of the EU’s researchers are women. In this context, ATHENA project aims at removing barriers to the recruitment, retention and career progression of female researchers; address gender imbalances in decision making processes and generate a cultural change needed to avoid future gender bias and discriminatory practices through the implementation of Gender Equality Plans (GEPs) in 6 Research Performing and 2 Research Funding organisations. These targeted organisations belong to Central Eastern EU countries and EU outermost regions that show some of the lowest Gender Equality Indexes in the EU. Thanks to the implementation of the GEPs, ATHENA will contribute to unlocking the research potential of these organisations thus improving the overall performance of the European Research Area and helping to close the innovation divide by avoiding the waste of talent and inefficient use of skilled women from weaker regions of the EU. To ensure systemic institutional change, ATHENA will first conduct an assessment of procedures and practices already in place in partner RPOs and RFOs, together with an analysis of the national legislation and policy frameworks. In parallel, it will put in place a participatory process aimed, on one side, to understand the needs and the preferences of the stakeholders and, on the other side, to train them with regard to selected topics related to gender. Based on these two approaches GEPs will be drafted, implemented and monitored in each partner organisation.

Keywords: gender equality,institutional change,gear tool,monitoring
A breakthrough respiratory monitoring device incorporating novel nanotechnology-based sensors (SenseGuard)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-04-01
End date: 2023-03-31
Duration (months): 36.0
Total project cost (EUR): 3567185.0
EU funding (EUR): 2497029.5
Participants: 1
Project status: SIGNED

Disease monitoring is key for patients with chronic respiratory conditions. Chronic Obstructive Pulmonary Diseases (COPD) is a long-term condition that causes inflammation in the lungs, making breathing difficult. It is a large growing public health problem, expected to become one of the leading causes of death by 2030. Nevertheless, COPD patients lack of a constant and accurate monitoring throughout their disease. This can result in non-adequate therapeutic measures, which can often lead to potential serious effects on patient’s status and high costs for healthcare systems. SenseGuard is a reliable solution for monitoring of patients with respiratory diseases, including COPD, based on a unique nanosensor-based technology. It is an innovative wireless wearable device that enables continuous and non-invasive monitoring of lung functions derived from patients' tidal (normal) breathing. NanoVation is an Israeli SME, founded in 2014, which develops and integrates nanomaterial-based sensors for medical applications and general purposes and is run by an experienced and multi-disciplinary team of 12 people. During the proposed Phase 2 project, NanoVation will finalise the development of the SenseGuard device and validate its efficacy and safety in dedicated clinical studies.

Keywords: copd,home monitoring,respiratory sensors
Controlling Activity of Lysogenic Phages by Small Molecule Inducers and Dysregulators (CAPSID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1992240.0
EU funding (EUR): 1992240.0
Participants: 1
Project status: SIGNED

The human microbiome has been increasingly in the focus of research for its importance in human health and disease. Yet, the viruses (phages) infecting these microbiota have gained much less attention. The majority of phages reside integrated in the genomes of their microbial hosts as so called lysogenic prophages. Often, these prophages encode important toxins and other virulence related factors that, while they are beneficial to their microbial hosts, may be detrimental for the infected human. Prophages can be induced under certain conditions to resume a lytic lifestyle resulting in the production of virus particles and often in the destruction of the host cell. Frequently, however, phage induction also leads to increased production of virulence factors. In this project, we aim to uncover small molecules modulating phage induction. We will explore to what extent microbial metabolites of human microbiota act as native triggers or inhibitors of phage induction and shape the complex interspecies interactions in the microbiome. The corresponding phage inducing or dysregulating metabolites will be isolated to elucidate their chemical structure and unveil their molecular targets. We will develop chemical tools to dissect and interrogate the responsible mechanisms and finally develop customized synthetic modulators that allow us to achieve control over the activity of phage-microbe systems with specific medical relevance. The integrated approach of the CAPSID project will provide first comprehensive insights into the chemistry of microbe-phage interactions and allow to assess its role for infectious diseases and its potential for customized treatment of microbial pathogens.

Keywords: microbial metabolites,natural product analysis,chemical probes,phage induction
Environmental indicators for agricultural adoption, success, and continuity in the Nile Delta (AGRICADOPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Archaeologists have long debated the origins of settled farming communities, and their appearance across the world at vastly different times, attempting to establish why and how the earliest farming settlements occur where and when they do. This is particularly true for the western Nile Delta, the region within which this training-through-research project focusses, and where the first sedentary farming communities in Egypt appear at c. 5,000 BC, e.g. at Merimde Beni Salama (MBS). The proposed research will apply two key methods using sedimentary analysis to assess the local environment in the hinterland and wider regional around MBS, which will require training in 1) recording, interpretation and analysis of sediments, and 2) thin section micromorphology description and interpretation. The application of these methods aims, overall, to elucidate the environmental setting before, during and after the settlement at MBS, as well as examining climatic data to highlight changes in the suitability/necessity for permanent settlement in the area by c. 5,000 BC, addressing these aims through the questions: 1) To what extent does the transition to settled lifeways depend on the arrival of new human groups bringing with them domesticated species and new technical knowledge; 2) Are the ‘new’ Neolithic lifeways an adaptation of the preceding Epipalaeolithic way of life in the region with the integration of some new groups and new knowledge, within a changed climatic/environmental setting; and 3) was the local environment specific to the western Nile Delta fringes especially well suited for the adoption and success of agriculture. The focal time range is c. 8000-3000 BC, covering the period during which the mobile Epipalaeolithic communities were present in the region, through the Neolithic period to the end of the Predynastic period when MBS goes out of use. The research will involve comparative artefactual analysis and be set within a framework chronometric dating framework.

Keywords: nile delta,environment,farming,neolithic,sedimentary,sedentary
Brokering China’s Extraversion: An Ethnographic Analysis of Transnational Arbitration (BROKEX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1490773.0
EU funding (EUR): 1490773.0
Participants: 1
Project status: SIGNED

Chinese global engagements are deepening across sectors and geographic regions. The objective of BROKEX is to fill specific gaps in knowledge about how China’s extraversion advances. The project takes an original approach by examining brokers who mediate in transnational fields. It opens the “black box” of China’s global integration by moving beyond descriptions of input and output characteristics to elucidate underlying dynamics. The objective will be achieved in two phases. First, the PI and two postdoctoral researchers will carry out ethnographic case studies in the Pearl River Delta, South China, that yield complementary information on the common challenge of brokering across geographic scales: * Connecting low-cost Chinese manufacturing with African markets; * Integrating Chinese academic research with global scientific communities; * Transnational architecture production. The diverse cases offer insights into the mechanisms of brokerage across distinctive sectors. In the second step, we build on the empirical findings and literature to develop brokerage theory. Social scientific research on brokerage commonly uses the morphology of social networks as its starting point, and focuses on how actors positioned at the intersection between groups operate. BROKEX adopts an innovative approach by examining how actors strategically seek to shape network morphologies in order to bridge gaps between groups. By directing theoretical attention towards relationship formation that precedes acts of brokerage, this line of inquiry advances understandings of how and why brokered connections emerge. Ethnographic case studies combined with critical theorization will generate new knowledge about the processes beneath the “rise of China” ─ one of the most consequential socioeconomic developments of our times.

Keywords: brokerage,ethnography,scale,china studies,petty trade,industrial upgrading,research governance
New roles for the cytoskeleton in cell-autonomous immunity to mycobacteria (MYCO TRAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cell-autonomous immunity is the ability of a host cell to eliminate an invasive infectious agent. Recent work has shown that components of the cytoskeleton have a major role in cell-autonomous immunity and control of bacterial infection. The Mostowy group has shown that some intracellular bacteria, including Shigella flexneri and Mycobacterium marinum, can escape from phagosomes and invade the host cell cytosol where they interact with cytoskeleton components to form actin tails or be entrapped in septin cage-like structures. However, our knowledge of these interactions derives from a limited number of in vitro studies, and has not been fully characterized in vivo during a disease-causing infection. M. marinum, a species closely related to the human pathogen M. tuberculosis, can be applied as a paradigm to understand the cell biology of mycobacterial infection. Zebrafish is naturally susceptible to M. marinum and, as I have shown during my PhD, can be used as an important animal model to gain in-depth information about the innate immune response to bacterial infection. Using state-of-the-art genome editing tools and high resolution microscopy techniques, I will study M. marinum interactions with the cytoskeleton, and investigate the role of these interactions in cell-autonomous immunity. Using M. marinum, my specific objectives are: 1) to identify and characterize host and pathogen determinants affecting autophagy-cytoskeleton interactions, and 2) to investigate the discovered molecules and mechanisms in vivo using the zebrafish model. A more comprehensive understanding of M. marinum-cytoskeleton interactions will have important consequences for enhancing host defense and fighting antimicrobial resistance. This should provide vital clues towards new strategies aimed at combating infectious diseases, and possibly other human diseases that arise from a dysfunctional host response.

Keywords: autophagy,cell autonomous immunity,cytoskeleton,mycobacterium marinum,septin,zebrafish
Indicator Monitoring for a new railway PAradigm in seamlessly integrated Cross modal Transport chains – Phase 1 (IMPACT-1)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Spain,Italy,Germany,Sweden,Sweden,Sweden,United Kingdom
Call: Start-up activities for System Platform Demonstrator Integrated Assessment and socio-economic effects (H2020-S2RJU-CFM-2015-01-1, 2015)
Start date: 2016-09-01
End date: 2018-04-30
Duration (months): 20.0
Total project cost (EUR): 299951.5
EU funding (EUR): 299951.5
Participants: 10
Project status: CLOSED

This Project will start the activities of Shift²Rail members related to the cross-cutting activities. The work Areas socio-economic aspects (WA1) and KPI Monitoring (WA2) as defined in the multi-annual action plan will start. The System Plattform Demonstrator Scenarios will be desigend in a first issue. The objectives of this proposal IMPACT-1 are: - Evaluating the effects for mobility, society and environment induced by new technology solutions and developments, - Introducing relevant targets and needs to create a more attractive, a more competitive and more sustainable rail system - Defining System Platform Demonstrators (SPD) that represent future application use cases - Defining Key Performance Indicators (KPIs) that enable the monitoring and assessment of the Shift2Rail overall target achievement. These objectives will be reached by performing a socio-economic impact analysis. Using these results scenarios for the System Platform Demonstrators are described with respect to the railway of the future for highspeed, regional, urban and freight transport. These scenarios are used to monitor the results of the other Shift2Rail projects using a mode of the KPIs. The model of the KPI shows the relation of the low-level KPI to the overall targets defined in the S2R Master Plan. The project IMPACT-1 is planned to fulfil the respective topic of the Shift2Rail Annual Work Plan 2015.

Keywords: key performance indicators,socio economic impact analysis,system platform demonstrators