Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clinical validation of a serum protein biomarker signature for the early diagnosis of pancreatic cancer. (IMMPACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 4244969.25
EU funding (EUR): 4244969.0
Participants: 1
Project status: CLOSED

The IMMPACT project aims to perform the clinical validation of a serum biomarker signature for the early diagnosis of pancreatic cancer. The biomarker signature is based on the world’s most advanced recombinant antibody microarray platform owned by Immunovia AB. The underlying technology is affinity proteomics. The biomarker signature hence exploits the body’s own detection network for the diagnosis of cancer. The initial retrospective clinical studies have confirmed that the biomarker signature can accurately separate pancreatic cancer patients from healthy individuals. The implication is that the signature, once validated by a robust method, has a very high potential for the short-term uptake into clinical practice. The European dimension of the project lies in the validation of the biomarker signature that will make it possible for the first time to accurately diagnose pancreatic cancer in an asymptomatic stage (I and II) when the cancer is resectable. The results of the project will help to build up evidence that pancreatic cancer can be detected at an early stage, thus laying the basis for the future implementation of screening programmes of population groups at risk. The project stems from the unmet clinical need for the early detection of PDAC. Pancreatologists need a reliable biomarker for the early diagnosis (yes/no) diagnosis of pancreatic cancer. The test should primarily indicate whether the patient has cancer, not if the patient has a high risk of getting cancer. The new biomarker signature will address those needs and allow Immunovia to benefit from the tremendous business opportunity. Immunovia’s business strategy is based on extensive efforts towards validating the new biomarker signature by retrospective and prospective clinical trials. The validation to be undertaken in the project will accelerate an international clinical uptake of Immunovia’s blood based-tests. The project is thus fully aligned with Immunovia’s business development strategy.

Keywords: protein biomarker signature,affinity proteomics,early diagnosis of pancreatic cancer padc,antibody microarray platform
Neuromicronica: Modular behavioural neuroscience (NEUROMICRONICA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Neurological disorders, particularly dementia, constitute arguably the greatest socioeconomic challenge to the aging European continent. There is growing realization that rodents can serve as models not just for basic neurobiological processes (e.g. synaptic transmission) but also for remarkably complex, primate-like and even human-like cognitive operations such as perception, memory, economics, social interaction, and decision making. Better rodent models for cognition are necessary to test theories on the molecular basis of neurological disorders and to test therapies: only through rodent behavioral neuroscience can the circuits that give rise to cognitive operations be examined and dissected, probed and manipulated. The aim of ERC Advanced Project ‘CONCEPT’ is to understand the neuronal bases of perception, memory and decision making. To achieve this aim, we have developed innovative instrumentation incorporating the following elements: (i) awake rodent interacting with its environment, (ii) precisely controlled sensory stimuli, (iii) imaging of animal’s action, (iv) electrophysiology with moveable microelectrode arrays, (v) optogenetics, (vi) integration and management of all incoming and outgoing signals. Here, we present our plan for bringing these instruments to a stage where they can constitute the initial product line for a spin-off named NeuroMicronica. The community’s interest in NeuroMicronica is already testified by the commercialization of the electrode drive in agreement with a prestigious USA company, by NeuroMicronica’s selection in a technology startup competition, and by the enthusiastic and constructive feedback from collaborators now employing beta versions. The expected outcome of NeuroMicronica will be to make this lab’s longstanding experience in instrumentation available to the community, allowing investigators to better exploit rodent behavioral neuroscience as a model for normal and pathological human cognition.

Keywords: behavioral neuroscience,instrumentation,neurophysiology,optogenetics,sensors,computerized control
Quantum simulations of insulators and conductors (QUIC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Switzerland,Poland,France,France
Call: Quantum simulation (H2020-FETPROACT-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 2774375.0
EU funding (EUR): 2386875.0
Participants: 7
Project status: CLOSED

It is now accepted that the conducting or insulating nature of matter is based on various separate ingredients (e.g. disorder, interactions, band filling, dimensionality, topology, etc.). However, their complex interplay is still beyond our understanding because experiments are very difficult and numerical calculations are often inefficient, even for supercomputers. In QUIC we want to achieve a breakthrough in the understanding of the fundamental mechanisms governing insulators and conductors by using quantum simulators, i.e. quantum computers of special purpose, based on fully controllable ultracold gases. In an experiment-theory enterprise, we will engineer several different kinds of such synthetic quantum matter, where we can isolate and study quantitatively the quantum phenomena and phases. We will not only study the physics of real systems, such as disordered and strongly-correlated superconductors and superfluids, but we will also create systems that do not exist so far in nature, such as topological phases in graphene-like lattices. QUIC combines for the first time advanced manipulation techniques of ultracold atomic gases, innovative theoretical ideas of condensed-matter physics and quantum-information methods. The immediate goals of our project are to understand quantitatively the subtle interplay of quantum phenomena in insulators and conductors, explore new promising directions for the engineering of transport in real materials, and lay the foundations for the design of the quantum materials of tomorrow.

Keywords: quantum simulations
VAlidation driven DEvelopment of Modern and Efficient COMbustion technologies (VADEMECOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-03-31
Duration (months): 60.0
Total project cost (EUR): 1499110.0
EU funding (EUR): 1499110.0
Participants: 1
Project status: CLOSED

Combustion science will play a major role in the future quest for sustainable, secure and environmentally friendly energy sources. Two thirds of the world energy supply rely on combustion of fossil and alternative fuels, and all scenarios forecast an increasing absolute energy supply through combustion, with an increasing share of renewables. Thus, combustion will remain the major actor in transportation and power generation as well as in manufacturing processes, like steel and glass. Nevertheless, combustion science will need profound innovation to meet future energy challenges, such as energy efficiency and fuel flexibility, and ensure future generations with affordable and sustainable energy and healthy environment. In this context, MILD combustion represents a very attractive solution for its fuel flexibility and capability to deliver very high combustion efficiency with virtually zero pollutant emissions. Such a combustion regime is the result of a very strong interaction between turbulent mixing and chemical kinetics. The fundamental mechanism of this interaction is not fully understood, thus justifying the need for experimental and numerical investigations. The overall objective of the present research proposal is to drive the development of modern and efficient combustion technologies, by means of experimental, theoretical, and numerical simulation approaches. New-generation simulation tools for MILD combustion will be developed, to reduce the dependence on sub-grid models and increase the fidelity of numerical simulations. High-fidelity experimental data will be collected on quasi-industrial systems, to disclose the nature of the interactions between fluid dynamics, chemistry and pollutant formation processes in MILD combustion. Experiment and numerical simulations will be tied together by Validation and Uncertainty Quantification techniques, to allow the ground-breaking application of the developed approaches and promote innovation in the energy sector.

Keywords: combustion,computational fluid dynamics,flameless combustion,mild combustion,oxy flameless combustion,oxy mild combustion,turbulence,chemistry interactions,validation
MilkTeeth: a biogeochemical investigation of ancient weaning and dairy Milk consumption using human Teeth (MilkTeeth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

Milk is at the centre of two great archaeological debates, with resonance today; infant weaning and dairy food consumption. Weaning timing has implications for infant health and mortality, and is strongly influenced by culture. While there are records of cultural ideas regarding infant nursing in the past, where historical accounts are not available or are of questionable accuracy, much remains a mystery. Archaeological studies of dairy consumption have also become part of the debate regarding costs/benefits of dairy in modern diets. Individual life histories can answer questions about milk use within populations, and population trends provide insights into milk consumption within larger social and cultural contexts. MilkTeeth is a pioneering, multidisciplinary, international action combining techniques to better address questions of weaning and dairy consumption in the archaeological record, providing greater understanding of both individual and cultural relationships with milk and dairy foods, and informing modern dietary debate. MilkTeeth will use traditional techniques from bioarchaeology (carbon, nitrogen and oxygen isotope analysis) and novel techniques from (bio)geochemistry (calcium and strontium isotope analysis) and proteomics (detection of the dairy specific whey protein β-lactoglobulin), and will have unique access to a Synchrotron Light Source beamline for Tender-Energy Spectroscopy (diagenetic assessment and mineralisation processes) to detect direct evidence of milk consumption using human teeth. It will bring together researchers from the UK and USA with expertise in ancient human milk consumption, bioarchaology, archaeology, instrumental chemistry, (bio)geochemistry, protein analysis and particle physics. By combining these traditional and novel techniques for the first time, both will be enhanced, resulting in a more precise and robust understanding of the human relationship with milk and dairy.

Keywords: milk,dairy,isotopes,proteomics,archaeology,bioarchaeology,weaning,calcium,strontium,carbon,nitrogen,oxygen,lactoglobulin,tender energy,bio geochemistry,diagenesis,mineralisation
FORTIKA - Cyber Security Accelerator for trusted SMEs IT Ecosystems (FORTIKA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Ireland,Italy,Belgium,Greece,Greece,Bulgaria,Slovenia,United Kingdom,United Kingdom,United Kingdom
Call: Cyber Security for SMEs, local public administration and Individuals (H2020-DS-SC7-2016, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 4918812.5
EU funding (EUR): 3997025.0
Participants: 18
Project status: CLOSED

FORTIKA aims to (1) minimise the exposure of small and medium sized businesses to cyber security risks and threats, and (2) help them successfully respond to cyber security incidents, while relieving them from all unnecessary and costly efforts of identifying, acquiring and using the appropriate cyber security solutions. To fulfil its vision the project adopts a security by design hybrid approach that adequately integrates hardware and software with business needs and behavioural patterns at individual and organisational level to: introduce a hardware-enabled middleware security layer as add-on to existing network gateways; orientate small business users to trusted cyber security services (through FORTIKA’s marketplace) packaged to tailored solutions for each enterprise and further extended to accommodate security intelligence and to encourage security-friendly behavioural and organisational changes. Ultimately, FORTIKA proposes a resilient overall cyber security solution that can be easily tailored and adjusted to the versatile and dynamically changing needs of small businesses. To this end, the project ambitiously aims to make systematic and extensive use of the existing service and product portfolio of security solution providers across Europe. Finally the introduction of a software-defined smart ecosystem in “FORTIKA Marketplace”, will provide the feature of a light mode solution, which will offer virtualized security services (with minimum downloading requirements). From their perspective, users (i.e. SMEs) may utilize a variety of services and share profiling information with the service providers in return for tailored security services aligned with their actual needs. The FORTIKA marketplace will also function as a single point of access for the profiling information for each SME. FORTIKA Cyber-security framework will be evaluated through five major types of SMEs and will be supported from 2 local SME/ICT clusters and 1 EU alliance.

Keywords: fpga soc accelerator,embedded security mechanisms,marketplace,homomorphic encryption,virtual security appliances,root cause analysis and mitigation
Indra HVDC Distribution system (INDIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: An innovative Electrical Power Distribution System (EPDS) for Small Aircraft (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-10-01
End date: 2021-09-30
Duration (months): 48.0
Total project cost (EUR): 1355388.75
EU funding (EUR): 948772.13
Participants: 1
Project status: CLOSED

The INIDIS proposal, presented by INDRA SISTEMAS, try to answer in the best way the call JTI-CS2-2016-CFP04-SYS-03-07. The proposal is based in the prototype development for a new electrical power distribution system (or n-EPDS) to be placed in small aircraft and helicopter. The main challenges of the project is to perform the main power distribution in HV (270Vdc) to gain advantages of this electrical characteristics in small aircraft (low-medium installed power). And in order to improve the operability in this new EPDS, the traditional contactors will be replaced by new smart-contactors (E-HVContactor) and with high power solid state switching (HVHP-SSPC)s. Moreover, as aditional challenge and linked with the evolution of the new switching devices, the EPDS will implement an intelligent power management function (or IPMS) that will be in charge to optimize power demand, power installed and load sheeding. The proposal is framed inside of the SYS-ITD of the CleanSky2 program, and at the end of the project, a dedicated prototype will be delivered to the topic mangaer rig test for integration activities and integration tests. The project is based in 5 WPs (Definition and preliminary dTo esign, development, testing, Optimization and support of TM Rig tests and Project management and dissemination). Two protopypes + subassemblies will be manufactured for internal tests and for delivery to TM Rig Tests. Although this is the Indra proposal, Indra will open to rework proposal during negotiation phase and specification availability according to the necesities of the topic manager and the SYS-ITD in general. Indra has a vast experience in the aeronautical sector. Indra is a consolidated and certified aeronautical supplier according to aeronautical and international standards with capability and resources to perform activities of analysis, simulation, design, manufacturing, testing, qualification, certification support and customer/airline support (as mentioned in Part B.II).

Keywords: high voltage,power distribution,dc converter,distribution box,epdc,270vdc,28vac,sspcs,e hvcontactor,ipcs
Tracing tropical timber (Timtrace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 148387.0
EU funding (EUR): 148387.0
Participants: 1
Project status: CLOSED

An estimated 50% of the tropical timber that enters the European market is illegally harvested. To implement new European legislation intended to eliminate this illegal trade, independent tools will be needed to verify the legal status of timber. We therefore propose to develop a fast, accurate and cost-effective commercial forensic tool, 'Timtrace', for tracing the claimed origin of tropical timber. Timtrace uses (1) ring-width measurements that can be matched with reference measurements or climate data, (2) stable isotopes in the wood that can be matched with regional reference data, and (3) DNA analyses that allow distinguishing timber obtained from different areas. The application of multiple methods greatly expands the number of tropical timbers whose origin can be traced. Our forensic approach is competitive, as unlike current commercial alternatives, it does not require access to the timber in the country of harvest. Potential customers of Timtrace include the customs and inspection authorities, the timber-processing industry and organisations that certify sustainable forest management. Several of these stakeholders have already shown interest in a commercially available and cost-effective forensic tool for timber tracing. Timtrace builds on the results and expertise obtained during the ERC-funded TROFOCLIM project in which we assembled databases with many thousands measurements of tree-rings and stable isotopes for 20 tropical timber varieties from three continents. Results of the TROFOCLIM project will be directly applied for tracing tropical timbers and will also serve as reference data. We will use the ERC Proof of Concept Grant to (1) develop a fast, accurate and cost-effective tool for forensic tracing of tropical timber and (2) evaluate its commercial feasibility. By the end of the PoC project we aim to have a Minimum Viable Product which will satisfy the demands of the first customers.

Keywords: illegal logging,tropical timber,eu timber regulation,forensic studies
Regional, National and European Support for Photonics Innovation Clusters enhancing SMEs Innovative Potential (RespiceSME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Partnership: Photonics (cPPP)
Countries involved: Austria,Germany,Ireland,Germany,Spain,Sweden,Greece,Lithuania,France,United Kingdom
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 1109047.5
EU funding (EUR): 1109047.5
Participants: 11
Project status: CLOSED

RespiceSME will reinforce the innovative capacity of Europe’s photonics SMEs, clusters and national platforms by stimulating increased collaborations in and beyond photonics. RespiceSME proposes new approaches for stronger innovative effectiveness using a 3-dimensional approach, led by an experienced, representative, interdisciplinary team. In the 1st dimension, the project will develop a measure of the innovative potential for Photonics SMEs; the index will be integrated with a methodology for auditing innovative SMEs. Coaching on these tools will lead to their diverse application; enhancing the innovative capacity of 30+ photonics SMEs is targeted in the project. In the 2nd dimension, RespiceSME will develop new approaches for analysing value chains in close collaboration with clusters and national platforms. Empowering photonics SMEs and cluster managers to undertake early stage analyses of value chains, in the 3 separate domains of commercial intensity, technology readiness and innovative potential, will lead to more effective penetration by European photonics SMEs in global non-photonics sectors. Approaches will be demonstrated by new business collaborations in photonics, and using photonics, in manufacturing, energy and transport sectors. Harnessing the full innovative capacity of the European photonics infrastructure is the objective of the 3rd RespiceSME dimension. Best practices for enabling photonics SMEs access European and regional infrastructures, harness educational and training programmes aligned with their specific needs, determine next generation regional innovative smart specialisation strategies, and be better resourced by efficient public and private financial supports, can be transformative. RespiceSME will disseminate results using face to face and multimedia tools. 6 events, spanning cluster/national platform, inter-sectoral meetings, and B2B brokerage events and multimedia tools will lead to an intensification of research collaborations.

Keywords: smes,innovation clusters,cross sectoral,photonics,manufacturing,transport,energy,methodologies,tools,innovation audits,value chain analysis