Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Integration and demonstration of Large Stationary Fuel Cell Systems for Distributed Generation (CLEARGEN DEMO)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Denmark,France,France,Hungary,Spain,United Kingdom,Hungary
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-05-01
End date: 2020-09-30
Duration (months): 101.0
Total project cost (EUR): 10343142.6
EU funding (EUR): 4590095.0
Participants: 8
Project status: CLOSED

Certain industries, such as chemical production or petroleum refining have been identified as producing quantities of by-product hydrogen that can be used to produce clean, load-following power on a distributed basis, reducing reliance on fossil fuels. While the chemical production industry generally acknowledges the potential value of stationary fuel cell applications, the lack of multiple megawatt-scale European reference sites is a significant barrier to widespread adoption. The CLEARgen Demo proposal aims to address this need. Ballard Power Systems Europe (BPSE) (Denmark), supported by Ballard Power Systems (Canada), will make design improvements to the existing ClearGen(tm) system, building parts for a one-megawatt fuel cell system to meet the specific requirements of European customers. BPSE will also manage the project. HDF (France) will design installations, integrate, commission and operate the system at a demonstration site provided by AQUIPAC (France), validating and maintaining system performance over the duration of a two and a half year demonstration period. HDF will also realize all procedures for permitting, will prepare the site and will install facilities. JEMA (Spain) will be in charge of electrical integration of the fuel cell system to injecting electricity in the public grid. The CNRS-ICMCB (France) will be responsible for data analysis and dissemination of results. The total project duration is approximately sixty-five months. The objectives of the CLEARgen Demo Project are: 1) The development and construction of a large scale fuel cell system, purpose-built for the European market, 2) The validation of the technical and economic readiness of the fuel cell system at the megawatt scale, and 3) The field demonstration and development of megawatt scale system at a European chemical production plant. The demonstration site was chosen for the ability to provide a strong reference case so as to convince future operators of the relevance of large scale stationary fuel cell applications.

Keywords: proton exchange membrane fuel cell,by-product hydrogen from chemical production,megawatt scale demonstration projects,hungary,spain,smart grid,lifecycle cost reduction activities
Zebrafish as Novel Model for Exercise-enhanced Skeletal and Cardiac Muscle Growth and Immune Functioning (SWIMFIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Recently, within the borders of a Marie Curie IEF project, we have established zebrafish as a novel exercise model and demonstrated the stimulation of growth by exercise in adult zebrafish (Palstra et al., PLoS ONE, 2010). Exercise may also induce hypertrophy and cardiomyocyte proliferation in zebrafish making it an important model to study vertebrate heart regeneration and improved robustness of fish in aquaculture. Moreover, zebrafish has been recently recognized as a valuable model for immunological studies since they possess an adaptive and innate immune system similar to mammals. Given the beneficial effects of exercise on mammalian immune function, zebrafish can be used to investigate exercise-induced stimulation of immune function. In this project we propose to use this novel exercise model for human and fish and, by applying state-of-the-art techniques, to demonstrate the mechanisms behind the beneficial exercise effects of enhanced skeletal and cardiac muscle growth and immune functioning, and to exercise glucocorticoid knock out and transgenic zebrafish to assess the role of the cortisol stress response at the base of these beneficial exercise effects. SWIMFIT will enable the development of a novel research line on exercise integrating the applicant’s existing expertise on exercise physiology with applying high throughput genomic, transcriptomic and proteomic methodology thereby creating a new scientific niche. At the Institute for Marine Resources and Ecosystem Studies (IMARES) of the Wageningen University, the applicant has postulated a position as researcher aquaculture and is investigating the opportunities for implementation of exercise in aquaculture. Besides these applied studies, this Marie Curie reintegration grant would offer the opportunity to deepen the initiated fundamental studies on zebrafish to demonstrate the functional mechanisms behind the beneficial effects of swimming using all the advantages that zebrafish offers as a model fish.

Keywords: aquaculture,animal physiology
TAKING STOCK: EXTERNAL ENGAGEMENT BY ACADEMICS (TASTE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

An extensive body of literature has examined academics’ engagement in knowledge-transfer activities. While much of the existing work has focused on assessing empirical relationships and phenomena, few contributions address how research on universities may yield more general theoretical contributions to the management literature. To fill part of this void, the aim of TASTE (TAking STock: External engagement by academics) is to gather new primary and secondary data on academics thereby illuminating (a) the social-cognitive determinants of academics’ enterprising behaviours, (b) how and to what extent academics’ individual characteristics shape the organisational environments in which they participate, and (c) the impact that institutional dimensions have on academics’ cognitions and behaviours. The study will be located in Italy, and it will be hosted by the Department of Management of the University of Bologna. Results will have implications for management theory and policymaking.

Keywords: technology transfer,academic entrepreneurship,individual characteristics,social-cognitive theory,institutional logics,survey data,longitudinal study,multi-level research design
Native-Born Youth of African Immigrants and Cardiovascular Risk: A Mixed Methods Study (BYAIMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-07-01
End date: 2016-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cardiovascular risk factors (CR) are the leading cause of morbidity and mortality in developed countries. By adolescence, CR of diet, exercise, blood pressure, body mass index, and smoking already are predictive of adulthood morbidity. Although genetics play a part in CR, health behaviors are the major contributors. Health status and service use differ between ethnic/racial groups (including immigrants) and the dominant population, but is this true of the influences on health behaviors? Europe and Israel are common destinations for international migrants from the least developed African nations. Capitalizing on a mixed-methods design and Community Based Participatory Research approach, this study will address ethnic/racial disparities in health care access by examining the influences of all four Bioecological Model's domains on cardiovascular risk factors in youth, comparing native-born youth of African immigrants (Ethiopians) to veteran Israelis. Qualitative interviews from 45 stakeholders and youth will be used to identify unique influences not found in existing literature. Informed by the interviews, quantitative surveys with new and established instruments will measure the impact of the four domain influences of the Model on CR. The surveys will be administered in three areas of Israel to a sample (n=600) comprised of two groups of 15-18 year old native-born youth, one born to African immigrants and the other to veteran Israeli parents. Using a variety of statistical techniques, the impact of each domain will be measured for all youth and each group. This study represents the first attempt to integrate the full range of domains on health behaviors affecting CR in youth, and disaggregate them for dominant society and second generation immigrant youth. Not only will this information inform the development of effective health care interventions for all youth, but it also will reduce ethnic/racial disparities for Europe's future generations of immigrants.

Keywords: behavioural sciences,immigrants,adolescence,public health,mixed-methods
Multiscale Fluid-Solid Interaction in Heterogeneous Materials and Interfaces (MULTISCALEFSI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Fluid-solid interaction (FSI) governs nature. From soft tissue modeling to lubrication technology, FSI problems in biomechanics and engineering are a major challenge in computational science towards understanding and emulating nature. This challenge is further intensified by the multiscale structure of materials and interfaces as well as by the finite configurational change (FCC) that a microstructure experiences under large deformations. The goal of this proposal is to conduct fundamental research on novel computational strategies for the modeling and analysis of multiscale FSI for materials and interfaces with FCC on all scales and homogenization as the core scale transition technique. The examples that will motivate and guide this research are potential future biological and industrial applications of the novel computational framework: (1) soft porous materials such as tissue scaffolds and articular cartilage that function together with pore-level fluids in order to facilitate organ regeneration and provide mechanical support, and (2) rough or textured compliant interfaces as in bearings and polymeric seals that deliver enhanced lubrication performance by increasing load-carrying capacity and decreasing energy consumption. The theoretical and computational basis of the envisioned research spans techniques from continuum and statistical mechanics. If successful, the major benefits of this research will be (i) a robust continuum FSI scheme based on the numerically efficient lattice Boltzmann method for the fluid coupled to the finite element method for the solid, which will constitute the basis of (ii) novel homogenization techniques that deliver a non-phenomenological description of advanced anisotropic porous media and lubrication theories, and which will ultimately yield to (iii) a multiscale framework through the application of recently developed isogeometric analysis techniques to macroscale porous media and lubrication interfaces. The overwhelming majority of the referenced research on which the present proposal rests has been conducted within the last 5-10 years, with major breakthroughs having been achieved only recently. Based on these recent advances, the vision in this proposal is to steer the macroscopic simulations of fluid-saturated materials and interfaces not with conventional phenomenological constitutive laws but solely through explicit microscopic FSI computations.

Keywords: computational models,simulation engineering,computational mechanics,multiscale modeling,homogenization,fluid-solid interaction,porous media,lubrication,finite elements,lattice boltzmann
Modelling and Optimization of Microfluidic Devices for Biomedical Applications (BIOMEDMICROFLUIDICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovakia
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic or primary cancers, including breast, prostate, and lung cancer. CTCs can be identified and counted in the peripheral blood of patients. The biological analysis of CTCs using lab-on-chip technologies effectively diagnose the disease, determine personalized therapies, and adjust treatments in real time. This significantly increases the survival chance of the patients. Because of their rare occurrence, a few CTCs per 1 mL of blood, the CTCs must be isolated from the blood sample. Recent developments of microfluidic devices made a significant breakthrough in the detection and filtration of CTCs from blood. The aim of the project is to incorporate rigorous optimization techniques in the development of such devices. In the design process of currently manufactured devices, the focus has not been put on the performance optimization. The use of mathematically justified optimization techniques offers huge potential for increasing the efficiency. A computer tool for simulation of complex processes inside microfluidic devices will be developed. A novel capture mechanism based on local affinity interactions will be elaborated. An optimization framework will be established and implemented in the software. With this framework, new devices with higher efficiency will be designed. During the designing process, different concepts will be optimized, e.g. geometry, blood flow velocities, external magnetic fields manipulating ferromagnetic parts of the device, and other. The optimization will be carried out in a rigorous way by applying iterative optimization techniques, which is a novel element in the development of microfluidic devices. The underlying physical models will be properly calibrated and validated, and the simulation and the optimization methods will be mathematically justified.

Keywords: magnetic beads,microfluidic devices,design optimization
Palaeofire Danger Rating Maps and Earth's Last Major Global Warming Event (Project PyroMap) (PYROMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Project PyroMap aims to understand the impact that Earth’s last major globally warm period had on our planet’s flammability. The Mid Pliocene ~3.6-2.6 million years ago, experienced global mean annual temperatures 3oC higher than today. Such estimates are remarkably similar to those predicted by the IPPC 2007 for 100 years in our future making the Mid Pliocene an excellent analogue for our planet’s future. Models of future climate change predictions suggest that the annual number of forest fires in N. America for example, will increase by 44%, implying that as our world warms we will be faced with an increased fire threat. Such estimates are based on outputs from numerical models that consider variations in lightning strike and climate-weather patterns due to increased atmospheric CO2. However, such an approach ignores variations in vegetation that supplies fuel for fires. PyroMap will assess whether past climate-induced vegetation changes influenced flammability. PyroMap will map vegetation changes across the Mid Pliocene in order to create the first palaeofire danger rating maps of the Earth. Fire danger ratings today are used to convey fire threat. These use mathematical models (fire danger rating systems) that link fuel type, fuel loads and climate to estimate ignition potential, spread rate and energy release from fires. PyroMap will create a modified danger rating system enabling palaeo-data to be used to estimate and map fire danger during the Mid Pliocene. PyroMap will: Provide sorely needed information on the coupling of fires and global warming. Produce the first ever palaeofire danger rating maps and the first global dataset on the influence of climate-induced variations in fuel on palaeofire activity. Produce data that will feed into the European Climate Change Programme II: Impacts and Adaptation, the European Commission’s April 2009 policy paper on “Adapting to Climate Change” and target the research goals of FP7’s “Environment” category.

Keywords: forest ecosystems (climate change),paleoclimate (climate change),paleontology,forest fires,fire activity
Vitamin C Biosynthesis in Citrus Species (VITACITRUS2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-12-15
End date: 2013-12-14
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main goal of this proposal is to discover the molecular basis of vitamin C (L-ascorbic acid, AsA) accumulation in citrus fruits. Gaining knowledge on this topic would lead to the identification of candidate target genes for future plant breeding that could contribute to improve citrus fruit quality. The research proposed in this project has three major objectives: the identification and characterization of the pathway/s involved in the AsA metabolism in citrus species, cellular localization of mRNA of the key genes involved in the AsA biosynthetic/recycling pathways and AsA histochemical localization in the different cell types of the fruit, and the identification of AsA modifiers by studying the natural variation resources. In summary, the project has a positive impact in several sectors of the society, first by increasing food quality we can improve human´s health and nutrition. Second and looking at the economic point of view, farmers, citrus processing industries and pharmaceutical companies could benefit from the data obtained through this study. Third and not less important, the project here described also contributes to increase the scientific knowledge and can provide with biotechnological tools extremely useful in academic research and food crop production.

Keywords: agricultural sciences,food products,agronomics,biological sciences,biology,applied biology,molecular biology,plant physiology,secondary metabolites (plant physiology)
Identifying new Markers and Homing Profiles involved in Lymphocyte Migration to the Female Reproductive Tract (FRT-HOMING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-09-17
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The effort to develop vaccines that can elicit mucosal immune responses in the female reproductive tract (FRT) against sexually transmitted infections (STI) have been hampered by an inability to accurately measure immune responses in the genital tract. Vaccines against STIs should generate localized memory responses at sites of potential exposure to provide better control of infection. Critically, lymphocytes isolated from the genital tract will migrate back into the FRT when transferred into a naïve recipient. Yet, the repertoire of trafficking molecules expressed on cells that will home to FRT is still unknown. The hypothesis of this project is that lymphocytes induced by FRT immunization traffic transiently in blood expressing a specific set of homing markers, but are selectively retained in the FRT after transmigration. By isolating cells from blood shortly after mucosal FRT immunization in animal models and FRT-mucosal infection in patients, we will be able to detect the potential specific integrins and homing receptors responsible for lymphocyte entry into the FRT. The goal is to identify specific integrins and homing receptors expressed on circulating T and B lymphocytes that direct their migration to the female reproductive tract during the brief period in which mucosal lymphocytes re-circulate. Direct comparison of gene and protein expression profiles using microarrays and mass spectrometry technology on subsets of purified peripheral blood will be performed in patients and murine models. Differentially expressed candidate molecules selected from these functional genomic analyses will be confirmed and validated in patients and by competitive homing assays in vivo in mice. Identifying the profile characteristic of lymphocytes migrating to the FRT soon after vaccination or infection will have a critical impact on the detection of recent exposure to a sexually transmitted pathogen and on the development of new STI vaccines.

Keywords: genital tract,homing,lymphocyte migration,systems biology,mucosa,vaccines,clinical analysis,sexually transmitted infections,female reproductive tract,proteomics,microarrays