Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mud volcanism and turbidites occurrence as joint tools to identify paleoearthquakes in the Gulf of Cadiz and adjacent abyssal plains (TURBOMUD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Paleoseismology is a relatively recent branch of earthquake-related studies but, since its birth, it is rapidly expanding back in time the earthquakes (EQs) catalogues worldwide. Its contribution to historical and geological EQs detection has shed light on one of the most crucial challenges of modern geology: high magnitude EQs recurrence and our ability to “predict” them. Only this way, improving the characterization of seismic hazard by estimating magnitude and recurrence interval between large events, one would be able to mitigate the seismic risk and implement proper prevention policies for the nearby population. The TURBOMUD proposal is aiming to expand and refine this knowledge for the Gulf of Cadiz (GoC) accretionary wedge, using a large dataset collected during the most recent and previous expeditions carried out in the region. An innovative research plan has been designed, which will conjugate mud volcanism and turbidites occurrence, to better estimate the seismic hazard for this convergent area. With the help of unique material and data, including two long sediment cores obtained with the seafloor drill rig MeBo, several gravity cores, as well as bathymetric and seismic surveys, an extensive study on the GoC paleoseismology will be implemented. Specifically, several statistical techniques will be used to post-process the data, which will allow to test synchronicity of EQ-related events. Following a pioneering approach, the proponent is planning to apply and integrate the classical methods for the study of turbidite deposits to the suites of techniques used to describe mud volcanoes’ episodicity, in order to pinpoint past EQ events. The novel idea of joining these two ways of studying subduction zones EQs will provide an enhanced understanding as well as a more exhaustive mean of EQ risk assessment for this region. Given the uncertainties in the available paleoseismological methods, the TURBOMUD project will contribute to a major advance in this field.

Keywords: mud volcanism,turbidites,paleoearthquakes,radiocarbon dating,fluid seepage
Advanced Regional Translation of Excellence into Medical Innovations for Delayed Aging (ARTEMIDA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Sweden,Slovenia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 499832.5
EU funding (EUR): 499832.5
Participants: 3
Project status: CLOSED

Our vision is to become by 2020 a Central and South-East European (CSEE) Centre of Excellence for Translational Medicine (CETM), coordinated by the Faculty of Medicine, University of Ljubljana that will harness, develop, exploit and market the significant potential for research and innovation in the region. The vision of CETM is to form the hub of an alliance of biomedical and health-related research and innovation institutions from CSEE. This long-term science and innovation strategy will be achieved by establishing a partnership between leading scientific institutions the Karolinska Institutet and the European Bioinformatics Institute on the one hand and the Consortium of teaching, research and health institutions and SMEs from Slovenia with partners from other low performing regions of CSEE on the other hand. Specifically, under the mentorship of these leading scientific institutions, the proposed CSEE CETM will upgrade, integrate, exploit and market the regions research and innovation potential in the field of aging with special reference to neurodegenerative diseases, diabetes and cancer in Slovenia, with partners from Albania, Bosnia and Hercegovina, Bulgaria, Croatia, Czech Republic, Greece, Hungary, NE Italy, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, Slovak Republic and European part of Turkey (population of about 100 million). The proposed CETM has the potential and ambition to use the Teaming seed money to stimulate inter- and intra-regional networking of research and innovation clusters thus promoting collaboration on large-scale research and innovation grant applications or clinical studies in the field of translational medicine. The vision of the CETM includes: 1. Spreading innovation-focused, research culture in CSEE and developing marketable products and services; 2. Developing a properly functioning, accountable, transparent, service-oriented CETM administration in accordance with relevant ISO standards for customers’ satisfaction.

Keywords: translational medicine,healthy aging,innovation,diabetes,cancer,neurodegenerative disease,data management,bioinformatics,personalised medicine
A Comparative History of Insurance Law in Europe (CHILE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1992500.0
EU funding (EUR): 1992500.0
Participants: 1
Project status: CLOSED

The objective of the project is to work out interactions between the national developments of insurance law in Europe, to explore the possibility of common historical roots of European insurance law, and to reassess the history of insurance law in Europe. The project does, thereby, aim at creating a historical basis for a European legal scholarship in the field of insurance law. Today’s state of research in the field of the history of insurance law is unsatisfactory: with the exception of maritime insurance, modern research focuses on national developments and the history of insurance law is told differently in the European countries. Even though modern research suggests that there have been interactions between the national developments these interactions often appear to be only footnotes to a mainly national development. For the first time, the project takes these points of interactions as a starting point for an in depth research into the history of insurance law in Europe. It is, to take an example involving England and Germany, known that English life and fire insurers where present on the German market since the late 18th century and that those who, in the beginning of the 19th century, were involved in founding the first commercial life and fire insurers in Germany had been working for English insurers. What needs to be explored is what impact this had on the practice and standard contract terms of German insurers. On the basis of the research into this and other points of interactions it will, for the first time, be possible to research into the doctrinal history of insurance law on a European level. The project will help to reassess the history of insurance law in Europe and it will create a historical basis for a European scholarship in the field of insurance law: the harmonization of European insurance contract law is on the agenda. Comparative historical research will help to understand the existing differences between the insurance laws in Europe.

Keywords: comparative legal history
Device for reduction of emissions and fuel consumption, optimizing combustion by treatment of fuel on the vehicle (ECO CARS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ECO-CARS® device is a fuel optimizer to achieve more efficient combustion, applicable in internal combustion engines (both gasoline and diesel). ECO CAR has the next features: • ECO-CARS® consists only of MINERAL. • Does not contain chemicals or products MAGNETS Eco-Cars is a very innovative product that dramatically reduces fuel consumption and emission in almost any kind of vehicle by treating the fuel with a patented solution of minerals.Eco-car increase life expectancy and power of any combustion engine (cars, motorcycles, trucks, buses, machinery, boats, generators…) Eco-Cars consists of a set of minerals when in contact with the fuel used in internal or external combustion engines reacts inhibiting the influence of external magnetic / radio-electric / electromagnetic fields. These fields may affect fluids, liquids and combustible fuel gases. The eco-car solution allows: • Reduce fuel consumption • Reduce emissions of gaseous, including CO2, NOx and other greenhouse gas. • Increase the working life of the engine Our Disruptive innovation is based on: • getting more electrons ready to mix in a better way with the fuel, usually oxygen, obtaining a better fuel gasification. • Every single fuel, due to its specific structure, is under the influence of a certain amount of electromagnetic charge, generating a specific space distribution within its molecules. • Eradicating this electromagnetic charge we obtain a new molecular disposition in the space, changing the physicochemical characteristics of the fluid. Breaking down the electro-physical links we upgrade the possibility of combustion (with the oxygen) obtaining a better vaporization at the molecular level. • The effectiveness of Eco-car, is supported by several scientific, laboratory studies and certification bodies that attesting its performance and reliability (TUV Rheinland, http://www.tuv.com), INTA, ATISAE and other.

Keywords: saving,environment,emission reduction,efficicience,transport
Chemistry and Biology in Synergy - Studies of hydrogenases using a combination of synthetic chemistry and biological tools (CaBiS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1494880.0
EU funding (EUR): 1494880.0
Participants: 1
Project status: CLOSED

My proposal aims to take advantage of my ground-breaking finding that it is possible to mature, or activate, the [FeFe] hydrogenase enzyme (HydA) using synthetic mimics of its catalytic [2Fe] cofactor. (Berggren et al, Nature, 2013) We will now explore the chemistry and (bio-)technological potential of the enzyme using an interdisciplinary approach ranging from in vivo biochemical studies all the way to synthetic model chemistry. Hydrogenases catalyse the interconversion between protons and H2 with remarkable efficiency. Consequently, they are intensively studied as alternatives to Pt-catalysts for these reactions, and are arguably of high (bio-) technological importance in the light of a future “hydrogen society”. The project involves the preparation of novel “artificial” hydrogenases with the primary aim of designing spectroscopic model systems via modification(s) of the organometallic [2Fe] subsite. In parallel we will prepare in vitro loaded forms of the maturase HydF and study its interaction with apo-HydA in order to further elucidate the maturation process of HydA. Moreover we will develop the techniques necessary for in vivo application of the artificial activation concept, thereby paving the way for a multitude of studies including the reactivity of artificial hydrogenases inside a living cell, but also e.g. gain-of-function studies in combination with metabolomics and proteomics. Inspired by our work on the artificial maturation system we will also draw from our knowledge of Nature’s [FeS] cluster proteins in order to prepare a novel class of “miniaturized hydrogenases” combining synthetic [4Fe4S] binding oligopeptides with [2Fe] cofactor model compounds. Our interdisciplinary approach is particularly appealing as it not only provides further insight into hydrogenase chemistry and the maturation of metalloproteins, but also involves the development of novel tools and concepts applicable to the wider field of bioinorganic chemistry.

Keywords: biomimetic chemistry,bioinorganic chemistry,hydrogenases
Molecular Machines with Integrated Parts (MolMacIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 2471095.0
EU funding (EUR): 2471095.0
Participants: 1
Project status: SIGNED

The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large rely upon switching of individual components to carry out their functions—and the machines of the macroscopic world, which utilize the synchronized behaviour of integrated components to perform tasks more complex than the sum of the components. The aim of this project is to learn how to integrate the movements and chemistries of different molecular machine components. The proposed program is divided into three themes: Theme 1: Transport and synthesis by nanomechanical substrate positioning. We will integrate switching mechanisms with components that can attach and release a substrate, in order to develop methodology for the nanomechanical manipulation of substrates. We see this theme as reminiscent of the way that substrates are passed between sites in various enzyme complexes in biology. Theme 2: Sequence-selective synthesis using molecular assembly lines. We will integrate reactive molecular appendages with rotaxanes in which the macrocycle moves along a track through brownian motion, in order to develop molecular assembly lines. This theme is reminiscent of molecular-machine-mediated sequence specific polymerisation in biology, such as protein synthesis by the ribosome and DNA synthesis by some DNA polymerases. Theme 3: Transport with chemically fuelled molecular linear motors. We shall integrate ratchet mechanisms with chemically fuelled molecular pumps and walkers and use them to transport cargo between phases and to carry out synthesis via energy ratchet mechanisms induced by chemical fuels. This theme is reminiscent of how biological molecular motors drive chemical systems away from equilibrium, thereby enabling tasks to be performed, cargo to be transported directionally and work to be done.

Keywords: rotaxanes,catenanes,synthetic molecular machines
Vaccine for prevention and treatment of Trypanosoma cruzi infection (CRUZIVAX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Argentina,Spain,Germany,Germany,Germany,Belgium,Hungary,France,Portugal
Call: New anti-infective agents for prevention and/or treatment of neglected infectious diseases (NID) (H2020-SC1-2018-Two-Stage-RTD, 2018)
Start date: 2019-06-01
End date: 2025-02-28
Duration (months): 69.0
Total project cost (EUR): 9671160.08
EU funding (EUR): 8391240.29
Participants: 11
Project status: SIGNED

Chagas is a neglected disease endemic in 21 Latin-American countries caused by Trypanosoma cruzi. It is the largest parasitic disease burden in the Americas (>11,000,000 chronic infections) and the first cause of cardiac morbidity in poor rural/suburban areas. It became a worldwide concern as a result of mass migration with reports in 19 non-endemic areas (>1.3 million carriers in EU/USA). Treatment is difficult since acute infections have mild symptoms and remain largely unnoticed evolving to chronicity. Drug therapy is also long, often associated with side effects (10-30% interruption) and only active during early infection. The main objective of CRUZIVAX is to bridge the gap between preclinical and clinical development by performing preclinical and clinical phase 1 studies of a needle-free vaccine against T. cruzi with proven efficacy in preclinical models. The vaccine is based on a structure-engineered trivalent chimeric antigen lacking immune decoy sequences and an adjuvant promoting self-limited locally-restricted immune activation stimulating humoral and cellular immunity, which is expected to protect as prophylactic or therapeutic (combined with Benznidazole) vaccine. To achieve this CRUZIVAX will: (i) conduct preclinical studies in mice to assess immunogenicity and efficacy of different vaccine formulations in prophylactic and therapeutic settings, (ii) analyse the immunogenicity and efficacy of the best vaccine formulation in dogs and non-human primates, (iii) produce cGMP antigen and adjuvant by cost-efficient manufacturing (facilitated uptake by health systems with limited resources), (iv) perform a preclinical safety assessment of the vaccine, (v) conduct a phase 1 vaccine clinical trial in healthy volunteers, and (vi) carry out a health economics analysis to identify critical target-product profile parameters. The vaccine will strengthen the pipeline of products for Chagas disease, aimed at reducing disease burden and its social and economic impact.

Keywords: chagas,adjuvanted subunit vaccine,polyvalent t cruzi chimeric antigen,needle free,preclinical validation in mouse dog nhp,gmp production,toxicology,phase 1 clinical trial,health economics
Co-construction of the Health Promoting Sports Clubs-Policy Audit Tool (HPSC-PAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-09-19
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: SIGNED

Currently, 12% of European citizens participate in organised sport weekly. Scientists and policy makers have underlined that the potential of sports clubs to promote health has been underutilized, limiting its contribution to society. Beyond the promotion of physical activity, sports clubs can also promote social, mental and physical health and well-being among its participants, as well as playing an active role in sustainable development. With the increase of unstructured sports practices (individuals practicing on their own), sports clubs need to reinvent themselves, in regard to the services they offer to their participants and society. Previous studies have identified sports clubs’ policies as a key determinant in health promotion efforts, but these have been acknowledged by sports clubs managers and coaches as their biggest weakness, across European countries. My knowledge in shaping the theoretical model of health promoting sports clubs and implementing health promoting interventions in sport, will combine with Professor Woods’ experience in physical activity policies framing and implementation to generate a health promoting sports clubs’ policies analysis tool (HPSC-PAT). Three research objectives will contribute to this aim: (1) document policies of sports clubs having participated in a unique health promotion program: the “Healthy Clubs” initiative of the Gaelic Athletic Association, (2) identify how national to local health and sport policies are known and implemented by sports clubs and (3) co-construct a policy analysis tool with sports clubs’ stakeholders. The provision of the HPSC-PAT for sports and health professionals will support sports clubs in their engagement of EU policies on the potential of sport to serve the society by developing health promotion. I will enhance my competences in 1/policies framing and implementation analysis, 2/ project application and management, 3/ interdisciplinary and international research project, 4/event organisation.

Keywords: sports policies,physical activity policies,health promotion in sports clubs