Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Slow motion: Transformations of musical time in perception and performance (SloMo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1923190.0
EU funding (EUR): 1923190.0
Participants: 1
Project status: CLOSED

Slow motion is widely employed in popular media such as emotional movie scenes or in the broad-casting of momentous bodily and physical actions. Slow motion functions as a counterpoint to the perceived acceleration of life, and non-profit organisations and meditation practices promote its virtues. Slow motion is used as a beneficial rehearsal strategy in music, dance, and other movement-based arts and sports. This research proposal shifts existing boundaries by hypothesizing that the time-stretching mechanism of slow motion is a) associated with high emotional significance, b) beneficial for interpersonal coordination, c) relevant in cross-modal approaches with augmented feedback such as the sonification of human movements, d) reduces cognitive working memory load in learning. It is assumed that music as a temporal-motional art is central for the study of these processes, since music consists of structured time at different hierarchical levels and deeply “moves” people. The musical surface structure (on a note-to-note level) allows synchronisations at higher tempi compared to deeper structural levels (such as strong beats in a measure or phrases). Music may thus transform perceptions of motion and time. The proposed project contains three main phases, first addressing the perception of slow motion in music and dance in relation to the attentional, emotional and aesthetic effects on the audience. In the second phase, performance qualities are studied, addressing cognitive load, imagery, and interpersonal coordination at slow tempi. High-speed cameras, a 3D motion capture system and physiological measures are used to analyse the psychological and bodily processes involved. The final phase aims at the creation of three applications, including a learning app for portable devices, a film with super slow motion sequences based on the studies, and sonifications of Tai Chi movements. These applications present the aesthetic dimensions of slow motion to a wider audience.

Keywords: psychology of music,systematic musicology,music perception and cognition,performance
Hybrid EMAT-Vision solution for OPTImisation of advanced manufacturing process of automotive tailor welded BLANKS (OPTIBLANKS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 1637375.0
EU funding (EUR): 1146162.5
Participants: 1
Project status: CLOSED

Production of high integrity vehicle components in Europe must be enhanced in order to optimize the implementation of lightweight materials which ensure that environmental impact is minimised. The use of Tailor Welded Blanks, (TWB) is an advanced manufacturing technique that ensures that production of automotive parts is carried out with resource efficiency. However, this technology still struggles with technical and reliability consistency during production. Innerspec is a global leader in Ultrasonic EMAT technology for automotive TWB inspection, and have sold and installed TWB inspection units in production lines worldwide. OPTIBLANKS project will overcome the limitations of automotive TWB manufacturing process by maximising weld quality control with a novel Hybrid technology approach. The outcome of this project will help improving the results of current state of the art alternatives and will boost Innerspec Technologies growth while saving TWB manufacturers accross Europe more than 9.000 Tons of wasted materials per year. The verified design of a Hybrid inspection system will enable 100% inspection of autogenously laser welded parts to identify defects such as porosity, lack of root penetration, lack of side wall fusion, etc. Innerspec will commercialise this equipment within the target market worldwide offering paying users unique benefits and a ROI of less than a year in most cases. The equipment will enable a reduction of scrap materials of more than 50% compared with competing solutions. Equipment sales are expected to boost Innerspec´s growth and will generate more than 90 new posts in the company. Furthermore, it is expected that more than 300 skilled jobs for OPTIBLANKS system operators will be created accross Europe. Innerspec will initiate marketing and commercialisation activities during the project in order to ensure that automotive manufacturers worldwide and car passengers benefit from the enhanced TWB weld safety offered by this technology.

Keywords: tailor welded blanks,weld integrity,inspection,emat,weld quality,visual inspection
Assessing Legacies of Past Human Activities in Amazonia (ALPHA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1481378.0
EU funding (EUR): 1371682.34
Participants: 2
Project status: SIGNED

Amazon forests contribute vital ecosystem services, including maintaining biodiversity (>10,000 tree species) and storing large amounts of carbon. Amazonia also features prominently in global climate, carbon, and vegetation models, which assume tropical forests are effectively pristine and that past human disturbance mimicked natural processes. It is now evident that recurrent human disturbance of Amazonia, like fire and deforestation, were significant in some areas. Since those disturbances likely modify subsequent vegetation dynamics - including temporarily increasing forest capacity to absorb carbon - the emerging paradigm of human disturbance is a challenge to global ecological understanding. The focus of my project is thus to reliably determine whether human disturbances occurred in locations that form the basis of global models. A key expected outcome is to either legitimize or force revision to these models of carbon sequestration potential in Amazonia. I will innovatively integrate ecological, paleoecological, archaeological, chemical and biogeographic analyses to assess the degree to which past human disturbance drives the diversity patterns and carbon dynamics observed in modern Amazonian forests. For key long-term sites across Amazonia, I will quantify the: i) time since the last fire, ii) past fire frequency, extent and intensity, iii) past vegetation change in the presence and absence of human activity, and iv) continuity of past human activity over the last 1000 years. My results will provide the first quantification of local-scale recovery processes exceeding 100 years in tropical forests, and will determine if observed forest dynamics are driven by disturbances that occurred before modern ecological surveys began. I will then quantify the extent to which past disturbances create an overestimation of carbon storage potential, driving a profound reexamination of carbon sequestration and biodiversity patterns in Amazonia.

Keywords: disturbance ecology,fire,cultural history
Single-Molecule Epigenetic Analysis of Plasma Isolated Nucleosomes for Colon Cancer Diagnostics (EPINuc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2022-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in medicine, with developing methods aiming to utilize it for diagnostics of cancer and additional pathologies. Most liquid biopsy methods are sequencing-based and provide limited information, usually relying on the detection of rare cancer-associated mutations. Therefore, they are costly and highly limited in their sensitivity. Importantly, blood cfDNA consists predominantly in the form of nucleosomes, which maintain their tissue-specific epigenetic modifications. Thus far, this rich epigenetic information has been inaccessible due to technical limitations. We developed EPINuc, a novel single-molecule multi-parametric-based assay to comprehensively profile the Epigenetics of Plasma Isolated Nucleosomes. Our approach is based on a technology we developed (Shema et al., Science), which allows high resolution profiling of combinatorial modification states on millions of individual nucleosomes by single-molecule imaging. EPINuc is unique in its capacity to generate multi-layered information from very limited liquid biopsy material. As proof of concept, we applied it to diagnose colorectal cancer (CRC), which is one of the most common cancers worldwide, necessitating expensive and invasive screening tests for all adults older than 50. Strikingly, EPINuc revealed significant differences in the epigenetic states and protein biomarkers’ levels between healthy individuals versus CRC patients. In this PoC, we will optimize EPINuc to generate holistic data from plasma-isolated nucleosomes that is expected to identify cancers early from a routine blood test, without the need for invasive measures. This technology has significant commercialization value for the liquid biopsy industry. We will develop a commercialization strategy and network with potential collaborators, customers and investors to spin out the innovation as a successful assay technology business.

Keywords: liquid biopsy,single molecule,epigenetics,cancer
RISK-BASED SCREENING FOR CERVICAL CANCER (RISCC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Switzerland,Slovenia,Sweden,Belgium,Finland,France,Netherlands
Call: Towards risk-based screening strategies for non-communicable diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 5792355.0
EU funding (EUR): 5792355.0
Participants: 11
Project status: SIGNED

Screening for cervical cancer is a globally recommended public health policy. Many risk factors are known, but so far only “one-size-fits-all” screening programs have been implemented, providing suboptimal protection for women at high risk, suboptimal allocation of resources and substantial screening-related harms. Development of risk-stratified screening is a priority, because cervical cancer is on the rise in many countries, the uptake of screening remains moderate in subpopulations at high risk, and costs related to screening are high. RISCC will develop risk-based screening based on screening history, HPV vaccination status and other relevant risk factors. Risk profiles based on screening history will be developed using joint data from several large European randomized HPV screening trials with long-term follow-up, HPV self-sampling trials, and registries of both cytology- and HPV-based screening programs. Risk profiles based on vaccination status will be developed for cohorts with varying screening and vaccination coverage using data from a community randomized vaccination trial, linked vaccination/screening/cancer registries, and a cohort of women vaccinated at screening age. Risk-based screening algorithms will be evaluated with respect to effectiveness, harms and costs by predictive and health-economic modelling. Finally, open source e-health and m-health applications using the risk-based screening algorithms will be developed to support implementation into real-life programs. The use of risk-based screening and a digital platform for screening invitations will be evaluated in an implementation trial within the Swedish organized screening program. The RISCC risk-based approach to cervical screening is directly related to the work program as it is based on a wealth of data sources on different, important risk factors for cervical cancer, builds on open science enabling citizens, and could thus constitute a role model for personalized screening.

Keywords: cervical cancer screening,risk stratification,predictive modelling,health economic modelling,digital applications
Bioenergetic Effects of Anthropogenic Contaminants and Climate Change on a Keystone Arctic Seabird (BioenergArc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Global climate change and anthropogenic contamination are pressing problems of international scope. A paucity of knowledge exists regarding combined effects of climate change and contaminant exposure on bioenergetics and thermoregulation, effects which are projected to be especially pronounced in the high Arctic. Indeed, understanding joint effects of climate change and anthropogenic contaminants is a current research priority of the Arctic Council. In this project (BioenergArc), I will collaborate with leading French scientists at La Rochelle University to address this research area from a bioenergetic perspective, using a keystone Arctic seabird species, the little auk (Alle alle), as a model system. I will use field respirometry to elucidate whether exposure to a suite of contaminants (methylmercury, organochlorines, perfluoroalkyls) affects resting metabolic rate and thermoregulatory capacity in a fashion that could undermine the capacity to cope with climate change. I will also use accelerometry in combination with experimental manipulations to examine whether contaminant exposure affects field metabolic rate, activity patterns and responses to increased workloads. Finally, I will investigate whether variation in thermoregulatory capacity and energy budgeting affects spatial habitat use and fitness. BioenergArc will combine my expertise in behavioural and physiological responses to environmental change with my collaborators’ complementary expertise in Arctic ecophysiology, ecotoxicology and spatial ecology. I will receive advanced training in field respirometry and biologging, and expand my research in highly topical new directions. Results will be disseminated through top-tier publications, international conferences and public engagement, and communicated to working groups of the Arctic Council to promote conservation initiatives. The project will solidify my scientific reputation and serve as a critical stepping stone towards a permanent research position.

Keywords: bioenergetics,thermoregulation,anthropogenic contaminants,climate change,arctic seabirds
INTEGRATED DigitaL Framework FOR Comprehensive MARITIME DATA AND INFORMATION SERVICES (ILIAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Armenia,Spain,Estonia,Ireland,Italy,Israel,Spain,Spain,Germany,Spain,Italy,Spain,Norway,Bulgaria,Norway,Bulgaria,Greece,Greece,Tunisia,Belgium,Greece,Poland,Romania,Belgium,Romania,Belgium,France,France,France,Netherlands,Netherlands,Netherlands,Morocco,United Kingdom,Luxembourg,Portugal,United Kingdom,Portugal,United Kingdom
Call: Transparent & Accessible Seas and Oceans: Towards a Digital Twin of the Ocean (H2020-LC-GD-2020-4, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 18956630.0
EU funding (EUR): 17046229.63
Participants: 58
Project status: SIGNED

ILIAD builds on the assets resulting from two decades of investments in policies and infrastructures for the blue economy and aims at establishing an interoperable, data-intensive, and cost-effective Digital Twin of the Ocean (DTO). It capitalizes on the explosion of new data provided by many different earth sources, advanced computing infrastructures (cloud computing, HPC, Internet of Things, Big Data, social networking, and more) in an inclusive, virtual/augmented, and engaging fashion to address all Earth Data challenges. It will contribute towards a sustainable ocean economy as defined by the Centre for the Fourth Industrial Revolution and the Ocean, a hub for global, multistakeholder co-operation. The ILIAD DTO will fuse a large volume of diverse data, in a semantically rich and data agnostic approach to enable simultaneous communication with real world systems and models. Ontologies and a standard style-layered descriptor will facilitate semantic information and intuitive discovery of underlying information and knowledge to provide a seamless experience. The combination of geovisualisation, immersive visualization and virtual or augmented reality allows users to explore, synthesize, present, and analyze the underlying geospatial data in an interactive manner. The enabling technology of the ILIAD DTO will contribute to the implementation of the EU?s Green Deal and Digital Strategy and to the achievement of the UN Ocean Decade's outcomes and Sustainable Development Goals. To realize its potential, ILIAD DTO will follow the System of Systems approach, integrating all existing EU Earth Observing and Modelling Digital Infrastructures and Facilities To promote additional applications through ILIAD DTO, the partners will create the ILIAD Marketplace. Like an app store, providers will use the ILIAD Marketplace to distribute apps, plug-ins, interfaces, raw data, citizen science data, synthesized information, and value-adding services derived from the ILIAD DTO.

Keywords: digital blue growth,immersive visualisation,geovisualisation,interactive simulation,sustainable ocean economy,emerging digital technologies for the ocean,digital twin of the ocean,marine data
CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level (CellViewer)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Spain,Czechia
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-02-01
End date: 2020-09-30
Duration (months): 56.0
Total project cost (EUR): 3988752.5
EU funding (EUR): 3988752.5
Participants: 6
Project status: CLOSED

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and software development) to collect at high-resolution a large amount of spatial and dynamic information in single cells. ‘CellViewer’ will allow us to study the mechanisms of mouse embryonic stem cell (mESC) self-renewal and differentiation upon application of specific stimuli, as a specific test case. We will analyse in single cells with high throughput, DNA remodelling at multiple specific gene loci and their corresponding production, distribution and kinetics of mRNA and protein products. We will collect a large amount of dynamic and nanoscale spatial information that will lead us to build predictive models of the phenotypic output from specific input stimuli. In turn, we will be able to develop a mechanistic understanding of how mESCs maintain their stemness or commit to differentiation. The partners of CellViewer are internationally recognized experts from academia and industry in the fields of stem cell and chromatin biology, super-resolution microscopy, quantitative modelling of biological systems, and hardware and software development. This team as a whole is uniquely suited to bring Systems Biology into the era of single cell analysis, which will be a paradigm shift in the way cellular systems will be studied.

Keywords: super resolution microscopy,stem cell self renewal and differentiation,single cell biology