Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantifying and Protecting the Privacy of Genomic Data (GenoPri)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-07-28
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

Genomic data carries a lot of sensitive information about its owner such as his predispositions to sensitive diseases, ancestors, physical attributes, and genomic data of his relatives (leading to interdependent privacy risks). Individuals share vast amount of information on the Web, and some of this information can be used to infer their genomic data. Hence, there is a need to clearly understand the privacy risks on genomic data of individuals considering publicly available information on the Web. It is also crucial to protect genomic privacy of individuals without compromising the utilization of genomic data in research and healthcare. The two main objectives of this project are (i) to develop a new unifying framework for quantification of genomic privacy of individuals and (ii) to establish a complete framework for privacy-preserving utilization, sharing, and verification of genomic data under real-life threat models. Graph-based, iterative algorithms previously developed by the applicant to efficiently analyze big data and make inference from it will be the foundation for the new quantification framework. To achieve the holistic genomic privacy objective, cryptographic tools, techniques from information theory, and statistics (differential privacy) will be used. This project will be a significant step towards understanding the privacy risks on genomic data of individuals and protecting the privacy of genomic data. It will also provide a new vision for security and privacy of health-related data in general and will find many implications in other domains such as banking and online social networks. The results of the project will also have an impact on future policies and legislation about protection of health-related data. This EF will have big impact on the future career of the applicant by helping him build new connections, enhance his expertise, increase his visibility in the field of security and privacy, and improve his independent research skills.

Keywords: genomic privacy,privacy enhancing technologies
DNA Damage and Repair and its Impact on Healthy Ageing (Dam2Age)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2251719.0
EU funding (EUR): 2251719.0
Participants: 1
Project status: SIGNED

We pioneered an initially highly controversial connection between DNA damage and (accelerated) aging. In the previous ERC grant ‘DamAge’ we reached the stage that (segmental) aging in DNA repair-deficient mice can be largely controlled. The severity of the repair defect determines the rate of segmental aging; the repair pathways affected influence which organs age fast; conditional repair mutants allow targeting accelerated aging to any organ. Importantly, we found that dietary restriction (DR), the only universal intervention known to delay aging, extends remaining life- and healthspan in progeroid Ercc1Δ/- mutants by 200% (see Vermeij et al., Nature 2016 and fig.2). Also Xpg-/- progeroid repair mice strongly benefit from DR, generalizing this finding. The prominent Alzheimer- and Parkinson-like neurodegeneration is even retarded up to 30-fold(!) disclosing powerful untapped reserves unleashed by 30% less food, with enormous clinical potential. Also we discovered that in accelerated and normal aging gene expression declines due to accumulating stochastic transcription-blocking lesions and that DR counteracts genomic dysfunction. In Dam2Age we will focus on the cross-talk between DNA damage, aging and DR with emphasis on the relevance for normal aging, elucidate underlying mechanisms and use our unique -for DR research superior- mouse models and a variety of novel assays to search for effective nutritional-pharmacological DR mimetics. This serves as a stepping stone towards potent universal therapy for a range of repair-deficient progeroid syndromes and prevention of many aging-related diseases, most urgently dementia’s, to promote sustained health.

Keywords: premature aging,nutritional intervention,dietary restriction,progeroid syndromes,mouse,models,dna repair defects,life healthspan extension,transcriptomics,bioinformatics,clinical,translation
Intelligent needle tracking using ultrasound imaging for improved minimally invasive interventions (INTUI-VIEW)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Germany,Norway,Netherlands
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2015-11-01
End date: 2018-10-31
Duration (months): 36.0
Total project cost (EUR): 3079660.0
EU funding (EUR): 2361697.0
Participants: 4
Project status: CLOSED

Developments in medical care are driven by increasing patient care quality and reducing cost. In the field of anaesthesia, the use of regional techniques has led to improved patient outcome and reduced costs compared to general anaesthesia. However, only 60% of anaesthesiologists perform peripheral nerve block procedures regularly. A wider adoption is hindered by lack of adequate technology. Currently they are largely navigating “in the blind”, using indirect measures as well as their anatomical experience to decide where they should inject. The INTUI-VIEW solution will change this. In the INTUI-VIEW project, Philips, B.Braun and Oslo University Hospital are partnering in order to bring an ultrasound tablet solution with needle tracking technology to the market. The solution is a revolutionary and new technique. It will speed up transition from general anesthesia to regional anesthesia. Patients will receive better, first time right regional anesthesia procedures, avoiding needle misplacements. The clinicians will receive a tool allowing them to do a safer, faster job with more predictable outcome. Finally, it will help hospital and health care systems to be more efficient by avoiding to waste expensive and limited resources. The scope of the project is to finalize the development of the INTUI-VIEW platform towards market introduction, industrialise and validate it in clinical settings, obtain regulatory approval and prepare market launch (2017). The two industrial partners are targeting a turnover of EUR 110 Mio in 2024, and a cumulative sales volume of EUR 700 Mio in 2024. Market adoption is expected to be 14% globally which translates into the treatment of 4.6 mln patients with INTUI-VIEW in 2024. In total, about 143 jobs will be created in both companies. In the R&D phase 30 FTE in Philips and 12 FTE in BBraun will be employed. After product launch 15 FTE in Philips (operations, service and support) and 86 FTE in B.Braun (production, marketing, sales).

Keywords: interventional ultrasound tracking technology regional anesthesia image guided therapy intelligent needles in body imaging and sensing miniaturized sensing technology
Modular thermoelectric system for industrial waste HEAT Recovery (HEAT-R) (HEAT-R)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Waste Heat (WH) emissions are a major economic and environmental issue, and the European legislation is increasingly pushing industrial companies to look for new solutions to reduce them. In this sense, Energy Harvesting (EH) techniques are one of the most promising sources of solutions, with a potential market of $250 million in the next 3 years. However, currently available EH solutions have important limitations mainly due to their low adaptability to different industrial settings and their high maintenance costs. HEAT-R proposes a new solution allowing the direct conversion of WH into electricity. It is a modular unit using multiple ThermoElectrical Generation cells associated and controlled through a programmable control unit based on System-on Chip technology, overcoming actual limitations by providing: • a large power generation capacity • a low-cost packaged solution • an adaptable and fully scalable system • a reliable, easy-to-install and maintenance-free product Current prototypes have been validated in relevant environments and one of the main objectives is now to scale up and adapt them to specific industrial requirements. In this sense, a demonstration within the premises of the first early adopter customer (SEAT-Volkswagen) will be performed during next months. The main objectives of HEAT-R are to validate the feasibility of the following technical, economic and impact aspects of the project: - Manufacturing process definition, including a Quality & Certification plan - New key partners identification - Industrial prototype validation - Know-how protection plan development - New customers’ requirements and needs identification (installation, validation, maintenance ...) - Market study improvement, including a deeper competitor analysis - Commercialization plan implementation (national and international strategies) - Target annual profit forecast validation (1.459.940€ in 2018) - Target direct qualified job generation (23 positions)

Keywords: waste heat recovery,thermoelectric generation,peltier cells,system on chip
Mobile links in fragmented landscapes: implications for biodiversity conservation (MobileLinks)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-01
End date: 2017-12-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Dispersal through anthropogenic habitats (i.e. the matrix) is necessary for the inter-population connectivity and the colonization of vacant habitats after disturbance, thereby for the long-term persistence of species in fragmented regions. A critical question for conservation is whether differences among species in dispersal translate into biodiversity loss through biotic homogenization. The ability of fleshy-fruited plants for dispersal though the matrix relies on their capacity to interact with those frugivore species that move across its habitats providing key seed dispersal services. Organisms that connect habitats in the landscape are termed “mobile links” and are considered essential for ecosystem resilience. However, there is a lack of knowledge about the mobile-link function in seed dispersal networks and its role on biotic homogenization. This proposal aims at filling this gap by providing a large-scale and integrative assessment of seed dispersal by avian frugivores through fragmented landscapes of Europe. Specifically, it aims at assessing empirically (1) whether interaction constraints between plant species and those frugivore species that act as mobile links are a driver of long-term biotic homogenization in fragmented regions; and (2) whether certain phenotypic plant traits that favour interactions with mobile-link frugivores could be used to predict ‘good dispersers’ and ‘poor dispersers’ of target plant communities. This proposal includes several study sites scattered through Europe, assuring generalization of the results. It combines field sampling and ground-breaking DNA-barcoding techniques for resolving seed dispersal networks, which will provide unprecedented information about the functional value of specific frugivore species in fragmented landscapes. Resulting knowledge can be incorporated into management and policy-making decisions for preserving woodland biodiversity in fragmented regions.

Keywords: habitat fragmentation,biotic homogenization,matrix,seed dispersal,avian frugivores,mutualistic networks,dna barcoding,migratory birds
LUMinous ElectroNic TILE (LUMENTILE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Finland,Switzerland
Call: Advanced Thin, Organic and Large Area Electronics (TOLAE) technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-04-30
Duration (months): 38.0
Total project cost (EUR): 2969176.25
EU funding (EUR): 2470113.75
Participants: 8
Project status: CLOSED

LUMENTILE originates from an idea of disruptive innovation, where the joint use of new technologies creates added value and new functionalities for traditional materials, thus turning the classical ceramic tile into a “multifunctional electronic luminous tile” realized by large area and organic electronics. LUMENTILE can be also considered as design-driven innovation, where we give a different meaning to the use of light driven by the design, by empowering it to be used as a radical different designed element for architecture, as a skin integrated element for interior design, lighting or advertising purposes. The demand for aesthetically integrated and creative construction elements is steadily increasing in many areas of business and industries. A growing number of designers, architects and industrial manufacturers across the world share a common interest in having new elements capable to create surfaces or coverings as creative and multifunctional solutions. LUMENTILE aims, on one side, to fill the gap between a simple construction element and a luminous surface element, and gooes far beyond, by developing a cutting-edge technologic module (the luminous electronic tile) that is capable of displaying lights, colors and images that can be used as a chameleonic display to be employed as a skin for horizontal (floor) or vertical (wall) applications. The final product will be an “on-the-fly” high energy efficient device that can be considered as a sustainable and competitive lighting element. On the other hand, the possibility of adding other sensors internally to the electronic tile enables it to increase the above mentioned properties (such as the detection of people walking onto it) and also to empower other creative or multifunction purposes. This project will address the above-mentioned challenges by exploring and developing new materials and integrated systems, manufacturing processes and business scenarios in luminous designed tiles and architecture.

Keywords: design driven solutions,ceramic materials,architectural design,interior design,out of home advertising,digital signage,large video screens
The birth of protein complexes (ComplexAssembly)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1957717.0
EU funding (EUR): 717179.09
Participants: 2
Project status: CLOSED

Protein complexes are central to many cellular functions but our knowledge of how cells assemble protein complexes remains very sparse. Biophysical and structural data of assembly intermediates are extremely rare. Particularly in higher eukaryotes, it has become clear that complex assembly by random collision of subunits cannot cope with the spatial and temporal complexity of the intricate architecture of many cellular machines. Here I propose to combine systems biology approaches with in situ structural biology methods to visualize protein complex assembly. I want to investigate experimentally in which order the interfaces of protein complexes are formed and to which extent structures of assembly intermediates resemble those observed in fully assembled complexes. I want develop methods to systematically screen for additional factors involved in assembly pathways. I furthermore want to test the hypothesis that mechanisms must exist in eukaryotes that coordinate local mRNA translation with the ordered formation of protein complex interfaces. I believe that in order to understand assembly pathways, these processes, that so far are often studied autonomously, need to be considered jointly and in a protein complex centric manner. The research proposed here will bridge across these different scientific disciplines. In the long term, a better mechanistic understanding of protein complex assembly and the structural characterization of critical intermediates will be of high relevance for scenarios under which a cell’s protein quality control system has to cope with stress, such as aging and neurodegenerative diseases. It might also facilitate the more efficient industrial production of therapeutically relevant proteins.

Keywords: protein complex assembly,local translation,cryo electron tomography,quantitative mass spectrometry,nuclear pore complex
Neural circuit dynamics underlying expectation and their impact on the variability of perceptual choices (PRIORS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Just as our experience has its origin in our perceptions, our perceptions are fundamentally shaped by our experience. How does the brain build expectations from experience and how do expectations impact perception? In a Bayesian framework, expectations determine the environment’s prior probability, which combined with stimulus information, can yield optimal decisions. While the accumulation-to-bound model describes temporal integration of sensory inputs and their combination with the prior, we still lack electrophysiological evidence showing neural circuits that integrate previous events adaptively to generate advantageous expectations. I aim to understand (1) how circuits in the cerebral cortex integrate the recent history of stimuli and rewards to generate expectations, (2) how expectations are combined with sensory input across the processing hierarchy to bias decisions and (3) whether the dynamics of the expectation can dominate neuronal and choice variability. I will train rats in a new auditory discrimination task using predictable stimulus sequences that, once learned, are used to compute adaptive priors that improve discrimination. I will perform population recordings and optogenetic manipulations to identify the brain areas involved in the computation of priors in the task. To reveal the circuit mechanisms underlying the observed dynamics I will train a computational network model to classify fluctuating inputs and, by adapting its dynamics to the statistics of the stimulus sequence, accumulate evidence across trials to maximize performance. The model will generalize the accumulation-to-bound model by integrating information across various time scales and will partition choice variability into that caused by the dynamics of the prior or by fluctuations in the stimulus response. My proposal points at a paradigm shift from viewing neuronal variability as a corrupting source of noise to the result of our brain’s inevitable tendency to predict the future.

Keywords: perceptual decision making,expectation,neuronal variability,behavioral variability,network model dynamics,drift diffusion model