Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors (ORGANITRA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1485274.0
EU funding (EUR): 1485274.0
Participants: 1
Project status: SIGNED

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.

Keywords: anion recognition,anion transport,dynamic combinatorial chemistry,transmembrane transport,liposomes,anionophores,nucleotides
Targeting microenvironment of cancer-invaded-nerves in pancreatic adenocarcinoma. (NERVASION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally aggressive cancer with a 5-year survival rate below 10%. It is resistant to traditional treatments and unresponsive to immunotherapy. New insights into the biology of PDAC are needed to identify novel therapeutic targets. Nerve invasion, defined as the presence of cancer cells along nerves and within different layers of nerve fibres, is a hallmark feature of PDAC. Patients that show signs of nerve invasion have a worse prognosis, higher risk of tumour recurrence, and suppressed anti-tumour immune responses. During PDAC, nerves form a dynamic microenvironment in which glial cells, neurons, stroma cells, cancer cells, and immune cells interact. The mechanistic basis of this communication and its effects on cancer progression remain undefined. Thus, in this project, cutting-edge transcriptomics technology preserving spatial information will be applied to human and murine PDAC tumour tissue sections. The cellular and molecular pathways dysregulated explicitly within cancer-invaded nerves will be identified, and the therapeutic potential of their targeting will be controlled in vitro and in vivo. The findings generated within this project could provide novel treatment strategies for PDAC and essential insights into the basic biology of cancer-nerve-immune interactions during tumorigenesis.

Keywords: tumor microenvironment,cellular niches,immune cells,nerves
Adding socio-economic value to industry through the integration of artists in research and open innovation processes. (VERTIGO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,Spain,Switzerland,France,France,Portugal,Portugal
Call: Boost synergies between artists, creative people and technologists (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2020-05-31
Duration (months): 42.0
Total project cost (EUR): 4258418.75
EU funding (EUR): 3998517.5
Participants: 7
Project status: CLOSED

The VERTIGO project provides a major opportunity to develop more inclusive, intercultural, and thus productive and innovative approaches to the participation of artists in ICT research activities and for promoting synergies between creative arts, businesses, research organizations and the society at general. If the digital economy of Europe is to prosper over the long term, then its full and diverse talent base must be effectively engaged into new and innovative research projects with commercial viability, and research, business, investment and art communities must work together towards these endeavours. Our proposal will fully support these objectives and contribute to set new policies for creating and nurturing links between Arts, Science & Technology in the ICT sector. The project will build from the H2020 ICT36-2016 call objectives and guideline of activities in order to propose a fresh approach, targeted specifically at the deployment of a brokerage service for integration of artists in ICT research & innovation projects and promotion of synergy between ICT research & business communities, entrepreneurs, investors and arts. We strongly believe in the role of arts and ICT as a trigger for business development and a catalyzer to Science, Technology, Engineering and Mathematics (STEM) promptness to innovate. We therefore situate our action in the framework of the STARTS (Science, Technology and the Arts) initiative supported by the European Commission with the aim of linking R&D and innovation with the art world including design and creative industries. We will build on the new Art-Innovation Forum, announced by Centre Pompidou’s President Serge Lasvignes in September 2015, and will aim at expanding IRCAM’s unique and successful model of R&D&I in sound and music technologies driven by creation in performing arts to other artistic disciplines (visual arts, architecture, design…) with a high public exposure, while also relying on other validated approaches across Europe and on a strong network of artistic organisations that will allows to tap into the potential of creators and artists for enhancing the innovation process.

Keywords: innovation,brokerage services,exploitation of research results,digital economy,artistic creation,co creation
innovAtive European POstdoctoral fellowship programme of GEnopolE BIOcluster (ApogeeBio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 3530880.0
EU funding (EUR): 1765440.0
Participants: 1
Project status: SIGNED

The ApogeeBio programme will propose 24 post-doctoral fellowships of 24 months within 3 international competitive calls. The objective of the programme, through such an ambitious joint action, is to foster the international attractiveness and visibility of the whole biocluster of Genopole, with the aim to attract high quality international researchers from Europe and all over the world. The fellows will be recruited in a world-class research and innovation environment with more than 2,400 people employed by 83 companies, 14 academic research laboratories, and 25 technology platforms and infrastructures. The ApogeeBio project cover interdisciplinary fields of research and innovation applied to health and environment. Through ApogeeBio, a higher level is reached compared to existing high-quality post-doctoral fellowship programmes in the biocluster. -Via an attractive position, including excellent working and research conditions, the programme will provide fellows with training and networking opportunities that will enhance their career development potential and boost the relevance of their work for other sectors within and outside academia, including regular interaction with private biotechs of the biocluster Genopole. -The ApogeeBio programme will not only rise the excellence of the biocluster and its research fellows but it will also help the implementation of European standards and stimulate adopting and sharing good practices to anchor the biolcuster Genopole as an active contributor to the ERA. The aim of ApogeeBio is also to support research excellence in Europe and favour the nurturing of highly-qualified researchers; it will help the fellows recruited to : - Develop Academic Independence - Enhance their Mobility profile by experiencing different environments, widening their perspectives, expanding their international networks, and gaining new opportunities for cross-sectoral and/or multidisciplinary collaborations - Boost career development

Keywords: biocluster,biotechnologies,genomics,biotherapies,world class research,intersectoral network,innovative infrastructures,interdisciplinary environment,career,trainings
Aviation Noise Impact Management through Novel Approaches (ANIMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Ukraine,Italy,Germany,Germany,Spain,Belgium,Hungary,Romania,Romania,Slovenia,France,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Reducing aviation noise (H2020-MG-2017-SingleStage-INEA, 2017)
Start date: 2017-10-01
End date: 2021-12-31
Duration (months): 51.0
Total project cost (EUR): 7645118.0
EU funding (EUR): 7479618.0
Participants: 23
Project status: CLOSED

Aircraft noise continues to cause adverse effects on quality of life and public health in airports’ neighbourhood. To address this challenge and ensure airports will have the capability to respond to the growing traffic demand, ANIMA aims to develop new methodologies and tools to manage and mitigate the impact of aviation noise, improving the quality of life near airports while facilitating airports growth and competitiveness of the EU aviation sector within the environmental limits, also considering 24/7 operations. Hence, ANIMA carries out critical review and assessment of noise impacts and existing management practices to establish best practices’ guidelines for an effective management of annoyance beyond ICAO Balanced Approach (WP2); develops a better understanding to address community annoyance, sleep disturbance and improve quality of life through pilot studies and surveys, assessing new methodologies reducing annoyance, testing novel and cost-effective solutions for land-use planning, using also mobile applications, the whole to derive new indicators (WP3); develops a 24/7 Noise Management Toolset to empower non-specialists with decision support capability and a 24/7 Design Toolset for researchers (WP4); tests and validates with end-users (airports and community) an “Aviation noise community platform”, gathering tools and best practices, facilitating consensus building and engaging communities in the mitigation process, ensuring exploitation of the results (WP5); supports the coordination of national and EU research activities, establishing a common strategic research roadmap for aviation noise reduction through the involvement of a pan-European network of experts and project leaders, also addressing international collaboration opportunities (WP6). ANIMA, a 4-year cost-effective project (total budget 7 479 618 €) builds on its consortium’s multidisciplinary excellence gathering 21 partners (Industry, SMEs, RTOs, Universities, airports and local authorities) from 11 countries.

Keywords: aircraft noise,annoyance,quality of life,sleep disturbance,health impact,land use planning,environmental noise directive,icao balanced approach,7 operations,european research network
Platform-aware LArge-scale Time-Series prOcessiNg (PLATON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2022-09-30
Duration (months): 12.0
Total project cost (EUR): 92353.92
EU funding (EUR): 92353.92
Participants: 1
Project status: CLOSED

PLATON brings together a highly-experienced researcher in the field of the theory of concurrent and distributed computing with a hosting group which has world-leading expertise on data series management, indexing, and analysis to harness the difficulties of large-scale data series processing by realising the data series processing performance and scalability goals. Specifically, PLATON aspires to build the necessary methods, algorithms and tools for highly-scalable and fault-tolerant processing of huge collections of data series by exploiting, for the first time, the full computational capacity (multiple nodes, multiple cores, accelerators) of modern heterogeneous computing platforms. The proposed research project, named PLATON (Platform-aware LArge-scale Time-Series prOcessiNg), has the potential of great economic and social impact in Europe as multiple scientific and industrial fields are currently in need of the right tools, in order to handle their massive collections of data series.

Keywords: data processing,large scale data series processing,big data,data series,multi node processing,multi threaded processing,accelerators,fault tolerance,scalability,high performance
EMIGRANT POLITICAL INCORPORATION: POLICIES AND PRACTICES (EMINCOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 171126.0
EU funding (EUR): 171126.0
Participants: 2
Project status: CLOSED

Internationally mobile citizens pose a challenge to policy-makers concerned with their political rights and participation. There has been a remarkable rise in countries extending voting rights to their non-resident citizens (emigrants) over the last two decades with 115 countries granting such rights by 2007. This project will examine the political participation and incorporation of emigrants along two main research objectives: First, it investigates the policies and politics of emigrant participation by questioning why states grant emigrants external voting rights. This will be done through a mixed methods approach including a) a large-N study where the main predictors include both transnational and domestic political variables; and b) a focused comparison of three cases (Spain, Italy, France) which compare the role of key stakeholders (including political parties and emigrants) in both the initial process of emigrant enfranchisement and subsequent restrictions or extensions to these rights. Second, the research focuses on practices and processes of emigrant political incorporation. This will be analyzed through a comparative study of the emigrant candidates based in North America, which are running for office in parliamentary elections in Italy and France. The project will compare the profile, motivation and strategies of the candidates in their negotiation with the political parties for whom they candidate. The research, to be carried out at Harvard University and the Autonomous University of Barcelona, presents a unique opportunity to build a transatlantic network and strengthen both my analytical and methodological toolkit. This will significantly enhance my career prospects. The project is expected to contribute to European policy debates on how to ensure more effective political participation of mobile citizens in their homeland.

Keywords: emigration,political incoporation,citizenship,transnationality
SmartCow: an integrated infrastructure for increased research capability and innovation in the European cattle sector (SmartCow)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Ireland,Germany,Spain,Belgium,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2017-1-two-stage, 2017)
Start date: 2018-02-01
End date: 2022-04-30
Duration (months): 51.0
Total project cost (EUR): 4999943.75
EU funding (EUR): 4999943.75
Participants: 14
Project status: CLOSED

SmartCow integrates key European cattle research infrastructures, to promote their coordinated use and development and thereby help the European cattle sector face the challenge of sustainable production. Covering all the relevant scientific fields and the diversity of cattle types and production systems, SmartCow will provide the academic and private research communities with easy access to 11 major research infrastructures from 7 countries (18 installations) of high quality services and resources. These are needed to develop innovative and ethical solutions for efficient use of animal and feed resources that promote animal welfare and healthy livestock, as well as sustainable competitiveness. SmartCow combines strong scientific and technical skills in animal nutrition (in vivo methods for nutrient utilisation and emissions measurements), genetics (genotyped animals, phenotyping capabilities), health and welfare (sensors and automatic recordings of physiological and behavioural traits) and ethics in animal experimentation. A central promotion and management of transnational access to the research infrastructures will provide access to around 10,000 cow.weeks and facilitate up to 33 research projects involving 59 users. Networking activities will harmonise and standardise procedures especially in animal care and measurements, design of experiments, data recording and analysis thanks to a cloud-based data-platform specifically developed in the project. Joint research activities will produce refined methods and proxies to evaluate feed efficiency and emissions, develop new protocols to reduce the use of animals and produce new methods to exploit sensor data for cattle husbandry. Promotion of transnational access and dissemination of SmartCow outcomes and innovations for maximum impact will be supported by a Stakeholder Platform composed of pre- and post-farm gate industry, farmer organisations, NGOs, policy makers at national and EU levels.

Keywords: livestock industry,cattle research infrastructure,sustainable agriculture,feed efficiency,greenhouse gases,animal nutrition,health,welfare,genetics,smart technologies,data analysis,ethics
Re-Industrialisation of the European Union 2016 (REinEU2016)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Coordination and support actions
Countries involved: Slovakia
Call: Presidency events (H2020-NMP-CSA-2015, 2015)
Start date: 2015-09-01
End date: 2016-12-31
Duration (months): 16.0
Total project cost (EUR): 877375.0
EU funding (EUR): 570000.0
Participants: 3
Project status: CLOSED

The main objective of the proposed conference REinEU2016 is to highlight and discuss the contribution of innovation to economic development in general, and the agenda of re-industrialisation in particular. Picking up on discussions at similar events during Luxembourg and the Dutch Presidency, our event will focus on the synergistic topic of the role of innovation in more traditional industries, and its effect on competitiveness. Based on that, the proposal stipulates three general objectives: developing expert discussion on the role of innovation in re-industrialisation, focusing on the intersection between novel technologies, approaches, etc. and traditional industries; contributing to better policy making in the areas of innovation support and industrial policies by providing evidence-based inputs, and feed-back from a wide range of stakeholders; and helping to widen the participation in Horizon 2020 and other actions, aimed at supporting innovation, especially by research institutions and companies from the Danube region and Poland, including non-EU countries participating in the Danube Strategy. Planned activities include plenaries and panel discussions with international keynote speakers, parallel thematic sessions, workshops and seminars, matchmaking for SMEs and research institutions, exhibitions of innovative companies, successful R&I projects and excellent research institutions, and public outreach activities, supported by a robust communication campaign.

Keywords: re industrialisation,innovation,presidency events,nmbp,conference,research,industry,policy making