Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Mnemonic system based on stimulation-free Neuroimaging (MNeuronic)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This project’s aim is the commercialization of a neurotechnology device, MNeuronic, that helps its users to improve their memory retention. MNeuronic can be used in cognitive rehabilitation on patients with mild to moderate decline in memory function as well as by healthy users, as a cognitive training method at home. The system will be mounted on wearable, relatively affordable hardware. Its core technology is grounded on principles and ideas developed in my current ERC-StG project on attention and perception. In particular, MNeuronic capitalizes on the natural fluctuations of neural excitability in the human brain using real-time phase prediction. This confers two important commercial strengths. One is efficiency, because MNeuronic anticipates upcoming optimal brain states before they occur, rather than reacting to past states. Second, MNeuronic affords unprecedented levels of temporal precision. Besides its direct application for memory enhancement, the core principles that ground MNeuronic are transferable to further applications in neurotechnology for learning/education, cognitive training, recreation (neurogaming) or, wellness. This opens a second commercialization route that reaches out to other neurotechnology companies, which will also be exploited in this project. The software implementing MNeuronic (real-time analysis filters and prediction algorithms) will be protected under a dual license that will allow us to combine a proprietary license offered to client companies, and open-licenses addressed to non-profit research and education organizations. Because MNeuronic offers non-invasive, stimulation-free solutions, it will appeal as a less aggressive rehabilitation support tool to be marketed in clinical contexts. In addition, with an effort toward affordable costs and wearable hardware, we intend to cater non-clinical, home-users. Home-use neurotechnology is becoming an increasingly important emerging market because its potential size and growth rate.

Keywords: neurotechnology,neurodevices,cognitive training,enhancement,cognitive neuroscience,rehabilitation,dementia,alzheimer s disease,memory,attention,integration,neural oscillations,prediction
The Bootstrap Method for General Amplitudes (Amplitudes Bootstrap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-15
End date: 2020-08-14
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Scattering amplitudes are our primary window on fundamental physics, but despite spectacular advances in recent years their computation remains extremely computationally intensive. Bootstrap techniques, in which an ansatz for the amplitude is constrained with limited kinematic data, are in principle the most efficient possible method, allowing researchers to skip both long sums over diagrams and complicated multidimensional integrals. My collaborators and I have shown the power of these techniques in six particle amplitudes up to six loops, quantities complex enough to be inaccessible to other methods. So far, though, we have applied these techniques only in planar maximally supersymmetric Yang-Mills theory. In this project, my objective is to generalize these techniques beyond the supersymmetric case, to build it into a powerful general tool for computing scattering amplitudes. I will pursue this objective in two ways: by investigating amplitudes that require functions outside of the polylogarithms that were used in earlier cases, and by bootstrapping quantities, such as correlation functions and amplitudes in non-planar theories, that have more general behavior.
An inventory of the prosimetra in vulgar tongue in the early centuries of Italian Literature (1250-1500) (InProV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2023-08-03
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

My research project aims to provide an inventory of the prosimetra written in volgar tongue (InProV) from the origins of Italian literature to the end of the fifteenth century (1250-1500). There exists an abundance of critical bibliography on specific major works written in prosimetrum, from Dante’s Vita Nova to Sannazaro’s Arcadia. However, this peculiar form consisting of prose and metre, which has customarily received cursory treatment in the history of Italian literature, appears only recently to have attracted scholarly attention (cf. Il prosimetro nella letteratura italiana, eds Comboni and Di Ricco, Trento 2000). Yet a thorough investigation resulting in a detailed inventory of the extant texts has not hitherto been attempted. In keeping with other works recently published (such as the Atlante dei canzonieri in volgare del Quattrocento, eds Comboni and Zanato, Florence 2017), the inventory will provide a useful instrument to gain a deeper understanding of the employment of the prosimetrum in the early Italian literary tradition when its use represented a third alternative to the literature either in verse or in prose before evolving into an imitative expedient or a literary exercise. The prosimetra included in the inventory will be examined according to specific criteria concerning textual tradition, typology (lyric, pastoral, philosophical, etc.), metre and subject-matter. The inventory will be published as a hard-copy and on-line, thus enabling researchers in different disciplines (Italian literature, comparative studies, philology, linguistics) to have easy access to extensive information on the prosimetra. Further, it will be possible to update the on-line version in accordance with potential new research findings in this field. The fellowship will give me the opportunity to bolster my academic career and to acquire new competencies in the analysis of early literary texts under the supervision of high-profile scholars in Renaissance studies.

Keywords: prosimetrum,dante,sannazaro,vulgar tongue,inventory
An insight into lysosomal signature in muscle wasting (Myo_LysoZOOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

Muscle wasting is the severe and progressive loss of muscle mass experienced in different pathological conditions such as cancer. The outcome of this debilitating condition on human health is detrimental; the effect on society is a public health burden. Attenuating muscle wasting ameliorates prognosis and survival in some circumstances; nevertheless, to date, a proper therapy preventing muscle loss is lacking. Partially responsible for this, is the fragmented knowledge of the signals controlling muscle homeostasis. Here I propose Myo_LysoZOOM as the groundbreaking tool for unraveling the mysterious relationship between lysosomal signaling and muscle atrophy. Through the harmonic and complementary interaction between me and the two groundbreaking realities, Whitehead Institute for Biomedical Research (MIT) and University of Padova, I will become the interpreter of this secret code named lysosomal signature in muscle wasting. Reinforcing my technical skills and boosting my scientific knowledge, this Marie Curie action will allow me to assume a unique prominent position in the European myology landscape. In turn, this will foster the development of a new research line through which I will be able to actively participate in the fighting against muscle wasting. Concluding, Myo_LysoZOOM will build a long-term terrific impact on European research, innovation, science and society.

Keywords: muscle wasting,lysosome biology,skeletal muscle metabolism
Revealing Fundamental Interactions and their Symmetries at the highest Precision and the lowest Energies (FunI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The four fundamental interactions and their symmetries, the fundamental constants as well as the properties of elementary particles like masses and moments, determine the basic structure of the universe and are the basis for our so well tested Standard Model (SM) of physics. Performing stringent tests on these interactions and symmetries in extreme conditions at lowest energies and with highest precision by comparing e.g. the properties of particles and their counterpart, the antiparticles, will allow us to search for physics beyond the SM. Any improvement of these tests beyond their present limits will require novel experimental techniques. To this end, we propose ambitious Penning-trap based single-ion experiments and measurements of magnetic moments and atomic masses to substantially improve the to-date best limits on some of the key SM predictions. While the measurement technique in determining the eigenfrequencies of the stored particles with unprecedented precision will be identical to the technique used in the past ERC grant by the PI (MEFUCO - MEasurements of FUndamental COnstants), the novel ion preparation and cooling techniques to be developed as well as the physics questions to be addressed are completely different. The new findings will enable us to perform stringent tests of fundamental symmetries like charge-parity-time reversal symmetry (CPT theorem) with (anti)protons or of the energy-mass equivalence principle as well as tests of interactions like quantum electrodynamics in strong fields by using highly charged ions. This will enable us to set new limits on SM predictions or even to reveal their failures. To meet these challenges, advanced charge breeding and cooling techniques will make it possible for us to achieve among other advances a ten-fold improved test of E = mc2, and thus of Einstein’s special theory of relativity and the most stringent CPT test in the baryonic sector by comparing the magnetic moments of the proton and the antiproton.

Keywords: precision measurements,laser cooling,penning traps,mass spectrometry,g factor measurements
Wideband optical antennae for use in energy harvesting applications - GreEnergy (GreEnergy)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Germany,Israel,Finland,Switzerland,Sweden
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3999065.0
EU funding (EUR): 3999065.0
Participants: 8
Project status: SIGNED

Energy is a vital need of humanity and a primary indicator a of nations’ growth. However, most energy sources we use have low efficiency, rely on non-renewable resources and cause severe damage to the environment. The cleanest resource, and the one which offers virtually unlimited energy is the sun. However, according to the Center for Climate and Energy Solutions, current solar photovoltaics (PV) produce little more than 2% of the world’s electricity. This low output is primarily resulting from two factors: current commercial solar PV cells have approximately 15-20% efficiency, and the price of a 1m2 is around €400. GreEnergy aims to develop a wideband optical antenna array with very high efficiency. The GreEnergy device will integrate the energy-harvesting component in a self-powering nano-system. A prototype of the integrated components will be developed incorporating nano-optical antennas with nano-rectifiers (rectennas) and a micro-energy storage component. Fabrication of all components will be developed with the aim of integration on a single microchip in a single fabrication process. To ensure success of the rectennas development, we will use a risk mitigation plan by dual research teams using both graphene and metal-insulator-metal based solutions to achieve rectenna prototypes (TRL4). Simulations will provide full system level circuitry, act as a benchmark of the proof of concept design (TRL3) and culminate in road mapping for future full-scale development and commercialization. Within GreEnergy, the targeted efficiency of the overall system is 20-40%, while the theoretical efficiency is over 90%, at an estimated system cost below €100 per 1m2. Such a technology would fundamentally change solar energy harvesting and have dramatic effects on consumers, society, economic growth and the environment. Further, demonstration of the system provides a proof-of-concept backbone for numerous future micro/nano-systems such as IoT and nano-sensor applications.

Keywords: self powering electronics,solar harvesting,optical wideband antenna,rectenna,system on chip,more than moore,nanotechnology,structural electronics,wearables,clean energy technology
Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo. (MAIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity. MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs. Using my expertise acquired in the US and building on unique tools, we will: 1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus. 2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes. The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota. By enabling me to permanently re-integrate the EU, this project will also guarantee transfer of technologies and creation of new bounds between the US and the EU, and will increase the EU competitiveness.

Keywords: host commensals interactions,thymic selection
Increasing penetration of renewable power, alternative fuels and grid flexibility by cross-vector electrochemical processes (BALANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: New knowledge and technologies
Action type: Research and Innovation actions
Countries involved: Italy,Switzerland,Poland,Finland,France,Netherlands,Denmark,United Kingdom
Call: European Common Research and Innovation Agendas (ECRIAs) in support of the implementation of the SET Action Plan (H2020-LCE-2016-ERA, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 2856096.25
EU funding (EUR): 2500596.25
Participants: 8
Project status: CLOSED

The main goal of the BALANCE proposal is to gather leading research centres in Europe in the domain of Solid Oxide Electrolysis (SOE) and Solid Oxide Fuel Cells (SOFC) to collaborate and accelerate the development of European Reversible Solid Oxide Cell (ReSOC) technology. ReSOC is an electrochemical device that converts electrical energy into hydrogen (electrolysis mode) or alternatively fuel gas to electrical energy (fuel cell mode). It is characterised by its very high efficiency compared to competing technologies. ReSOC enables to store renewable electricity when it is produced in excess or to convert it into a CO2-free transport fuel. Therefore, it is considered as a key technology to allow the broad penetration of renewable electricity into the European energy system. Fragmented national research efforts are currently impeding quicker development and deployment of next-generation fuel cell and hydrogen technologies. Therefore, BALANCE will identify, quantify and analyse national activities dealing with the diverse aspects of ReSOC technology. This analysis will result in an integrated European research agenda for ReSOC technology to gain synergies and to generate breakthroughs in this highly promising but currently low-TRL technology. Close communication with the advisory board will enable alignment of the proposed agenda with the roadmaps and activities of EERA, IEC and IEA on the topic of hydrogen technologies. Technical development will cover the development of the next generation of ReSOC cells, their integration in the optimised stack assembly, and investigation of the constraints from reversible operation at system level and integration with the grid. Cost will be addressed by using low-cost materials and improving manufacturability. The experimental work will be supported by modelling and simulation at all scales and by the techno-economic analysis of different integration of the ReSOC technology in industrial applications.

Keywords: electrochemical process,high temperature electrolysis,fuel cell,hydrogen
Everyday Writing in Graeco-Roman and Late Antique Egypt (I - VIII AD). A Socio-Semiotic Study of Communicative Variation (EVWRIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1476250.0
EU funding (EUR): 1476250.0
Participants: 1
Project status: SIGNED

This five-year project aims to generate a paradigm shift in the understanding of Graeco-Roman and Late Antique communication. Non-literary, ‘documentary’ texts from Ancient Egypt such as letters, petitions and contracts have provided and continue to provide a key witness for our knowledge of the administration, education, economy, etc. of Ancient Egypt. This project argues that since documentary texts represent originals, their external characteristics should also be brought into the interpretation: elements such as handwriting, linguistic register or writing material transmit indirect social messages concerning hierarchy, status, and power relations, and can therefore be considered ‘semiotic resources’. The project’s driving hypothesis is that communicative variation – variation that is functionally insignificant but socially significant (e.g. there are ~ there’s ~ it’s a lot of people) – enables the expression of social meaning. The main aim of this project is to analyse the nature of this communicative variation. To this end, a multidisciplinary team of six researchers (one PI, one post-doc, and four PhD’s) will apply recent insights form socio-semiotic and socio-linguistic theory to a corpus of Graeco-Roman and Late Antique documentary texts (I – VIII AD) by means of a three-level approach: (i) an open-access database of annotated documentary texts will be created; (ii) the ‘semiotic potential’ of the different semiotic resources that play a role in documentary writing will be analysed; (iii) the interrelationships between the different semiotic resources will be studied. The project will have a significant scientific impact: (i) it will be the first to offer a holistic perspective towards the ‘meaning’ of documentary texts; (ii) the digital tool will open up new ways to investigate Ancient texts; (iii) it will make an important contribution to current socio-semiotic and socio-linguistic research; (iv) it will provide new insights about humans as social beings.

Keywords: social semiotics,papyrology,graeco roman and late antiquity