Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human blastoids: a drug discovery platform for women’s reproductive health (BLASTOID-DISCOVERY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The first weeks of human pregnancy are crucial as early abnormalities or insults result in infertility. Therapeutics acting at the onset of embryonic development would offer huge opportunities to improve public health through effective family planning and to reduce an ongoing global fertility decrease with profound economic, social, environmental, and geopolitical consequences. Unfortunately, a drug development program on human embryos is unfeasible due to the inaccessibility and scarcity of embryos, and to ethical issues associated with them. As a result, the attrition rate of drugs for reproductive health is high for all major In Vitro Fertilization (IVF) and pharmaceutical companies. Recently, an alternative approach arose from stem cells self-organizing into structures closely resembling pre-implantation embryos (blastocysts), which we termed blastoids. Because stem cells can be largely multiplied, this embryo model provides a scalable and ethical alternative amenable to drug screens, thus opening numerous possibilities for therapeutic breakthroughs. Here, I propose to use human blastoids to discover molecules for women’s reproductive health. Blastoids offer a unique opportunity to establish a drug discovery program for early pregnancy and an alternative to the use of animal and human embryos. As such, this path has the potential to decrease the cost of drug development and to increase the rate of approved drugs for reproductive health. The aim of BLASTOID-DISCOVERY is to investigate the commercial feasibility of using blastoids as a new and highly cost-effective tool in the discovery of therapeutics for reproductive health.
Exploring Digital Participation with Children to Co-produce Knowledge for Active Neighbourhoods using SoftGIS methodology in Delhi, India (DigiPACK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

DigiPACK aims to demonstrate the potential of innovative digital participatory tools for mapping and comparing active mobility behaviour and localized experiences with children across their gender, age, socio-economic status and settlement typologies within the Global South context. The key research objectives are: (1) to adapt and contextualize SoftGIS methodology for enabling digital participatory planning with children in India; (2) to map and compare children’s active mobility behaviour (mode of transport, accompaniment, home-school route) and environmental experiences (location of meaningful places, frequency of visits, perceived environmental fears and likability index) across four dimensions of age, gender, socio-economic status and urban settlement typologies using SoftGIS; and (3) to evaluate the potential of SoftGIS methodology to integrate within India’s urban planning policy framework. Adopting a comparative case study approach, the SoftGIS data will be collected from children aged 10-17 years from middle and lower-middle-income families across three distinct neighbourhood settlement typologies of Delhi and analysed using quantitative statistical techniques. Actor-Network-Theory will be employed for evaluating the role of SoftGIS in the participatory planning policy framework. The project results, including contextualized digital methodology and new knowledge on how age, gender, socio-economic status and urban settlement influence children’s active mobility behaviour, will open up new research avenues and have the potential to revolutionize participatory urban planning with children in India, and the Global South more broadly. The 2-year project will be hosted by the Department of Built Environment, Aalto University, whose leading expertise in pioneering the SoftGIS methodology since 2005, will assist me in acquiring new technical skills and building strong European networks to pursue a career in academia within the Global South context.

Keywords: children s participation,ppgis,participatory mapping,neighbourhood planning
Nutrient redistribution by mammals as a key mechanism for ecosystem restoration (RE-NOURISH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: CLOSED

Declining soil fertility represents one of humanity’s major challenges in the 21st century. In the past, large vertebrate animals played a crucial role in transporting nutrients between ecosystems, supporting a more fertile planet. Today, however, species extinctions, diminished population abundances and constraints on animal movement have reduced animal-mediated nutrient transport by >90% compared to the late-Pleistocene. In contrast, anthropogenic use of certain nutrients (nitrogen [N], phosphorus [P] and potassium [K]) vastly exceeds planetary boundaries. Consequently, some areas of the world experience excessive nutrient pollution and others nutrient depletion. Agricultural abandonment trajectories provide opportunities for large-scale ecosystem restoration, including rewilding of large vertebrates. However, where humans have altered nutrient geographies, redistribution by wild animals may have unintended consequences for nearby ecosystems, including to plant productivity, carrying capacity, carbon storage and endemic competitive advantages. Consequently, changes to either anthropogenic nutrient loading or to animal dynamics during ecosystem restoration projects can have far-reaching implications. RE-NOURISH will develop an agent-based modelling framework that quantifies the redistribution of multiple nutrients across landscapes by different guilds of large mammals. Crucially, this model will include the direct and indirect influences of predators – an essential, but often overlooked aspect of nutrient redistribution in terrestrial landscapes. The RE-NOURISH framework will then be applied to two restoration case studies in (i) nutrient-deficient and (ii) nutrient-polluted environments. This transformative approach will directly help conservation practitioners achieve goals of ecological integrity and contribution to climate stability. Results will be disseminated via published papers, interactive workshops, conference presentations and popular articles.

Keywords: zoogeochemistry
EIT Urban Mobility Business Plan 2026-2028 (EITUM-BP26-28)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Knowledge and Innovation Communities
Countries involved: Spain,Germany,Denmark,Czechia,Netherlands
Call: EITURBANMOBILITY Business Plan 2026 (HORIZON-EIT-2025-KIC-IBA, 2025)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 206871493.0
EU funding (EUR): 206871493.0
Participants: 7
Project status: SIGNED

EIT Urban Mobility is Europe’s leading innovation community, accelerating the transition to sustainable urban mobility for more liveable cities. Building on our Strategic Agenda 2021–2027, its 3 societal impact goals and the achievements of its startup and ramp-up phase, the Business Plan 2026–2028 sets out an ambitious programme to deliver scalable, inclusive and impact-driven solutions through strong Knowledge Triangle Integration across education, research and business, aligned with EU policy priorities. Actions focus on 5 priority domains where change is most urgent and promising: Public and Shared Transport, Health and Mobility, Electrification and Alternative Fuels, Sustainable Urban Logistics, and Mobility Data Management, supported by cross-cutting technologies such as AI and robotics. This Business Plan raises ambition across all programmes, with a unified innovation call, later-stage investments, cofunding with corporates and VCs and stronger city engagement. It reinforces our role as a recognised thought leader, through communication, stakeholder engagement and dissemination aligned with EU priorities. It advances 5 strategic objectives: creating liveable spaces; closing the knowledge gap; deploying and scaling green, safe, inclusive mobility; accelerating market opportunities; promoting effective policies and behavioural change. Key priorities include scaling education, strengthening our role as an impact-driven innovation platform, embedding gender equality and inclusion, expanding impact investment, boosting RIS actions, and securing financial sustainability through diversified revenues (€38M+ projected by 2028). From 2026, a new Impact Assessment Framework will guide outcome-driven, city-centric monitoring and accountability, aligned with EIT KPIs. By combining innovation, investment, education and policy engagement, EIT UM will reinforce Europe’s competitiveness, deliver climate impact, and drive systemic transformation of urban mobility.

Keywords: european institute of innovation and technology eit education innovation impact ventures knowledge triangle ecosystem liveable urban spaces,mobility solutions,cities
Laser Technologies for Sustainable Self-Charging System Development (SUINK-HOP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Lithuania
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 32.0
Total project cost (EUR): 479500.0
EU funding (EUR): 479500.0
Participants: 2
Project status: SIGNED

SUINK is aimed to design and implement sustainable, flexible and printable self-charging power systems (SCPS) able to supply power to a wide range of sensors. The Hop-On project will enhance the project’s objectives and/or increase beyond the state of the art by novel concepts and approaches implementing circuit fabrication technology: Selective Surface Activation Induced by Laser (SSAIL)[1] for bioplastic materials. SUINK HOP-ON project will perform integration of the SUINK device by improving device bonding with automotive parts, increasing harvesting reliability and reducing consumption by device control and data transfer. SUINK HOP-ON will offer the integration of a sustainable bio-ink-based piezoresistive sensor. Therefore, SUINK HOP-ON will enhance the quantity of bio content in final applications. Moreover, it will enhance vibrational energy harvesting efficiency. The sensor integration with the communication node and reduced consumption of the device will allow to increase in technology readiness level and shorten self-charging power systems way to the market.

Keywords: sustainable,self charging,power systems,biopolymers,piezoresistive sensor,laser,adhesion,communication node,ssail,recycling
EFficient search FOR primordial feaTureS in current and future cosmological data (EFFORTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 292118.88
EU funding (EUR): 292118.88
Participants: 1
Project status: SIGNED

Primordial features (PFs) are scale-dependent deviations from the leading-order, scale-invariant spectra of primordial density perturbations, often manifesting as oscillations. These PFs arise from disturbances in the potential or internal space of primordial Universe models, which alter the background evolution from the leading trajectory. While the amplitudes of these features are uncertain, their presence is likely, and detecting them would offer insights into the physics of the primordial Universe, such as new energy scales and heavier degrees of freedom coupled to the inflaton field. This proposal aims to maximize the efficiency of the search for PFs in current and future cosmological data. I will test PF models against the most recent Cosmic Microwave Background and Large Scale Structure data for the first time using both the power spectrum and bispectrum of primordial fluctuations. At smaller scales, PF signals must be much larger to be detected through the Stochastic Gravitational Wave Background (SGWB) sourced by large scalar fluctuations. Focusing on the future LISA experiment, I will build an efficient code and pipeline to detect these signals in future data. On the theoretical side, I will also explore the contribution of loop corrections in these models, which may dominate over tree-level results, and design novel non-perturbative techniques to compute the spectra in these cases. This project will set the state of the art for analyzing PFs of any amplitude and at any cosmological scales.
TumoCure, Transformative Interventional Oncology Platform for single safe and effective solid cancer therapy (TumoCure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 30.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Solid cancers affected 18M people worldwide in 2022. Chemotherapy is among the 1st line of treatment, but its systemic toxicity and low distribution in the tumors limit its use in 30% of the patients. Within solid cancers, Head and Neck cancer (HNC) is considered the TOUGHEST TO TREAT, with the unmet need of 50% survival or recurrence, as 50% of patients can’t receive life-saving chemotherapy. Among those, 30% are surgically inaccessible, leaving them hopeless and doomed. Intragel brings a breakthrough INTERVENTIONAL ONCOLOGY platform enabling minimally invasive local chemotherapy, with higher drug loading and long-acting profile diminishing side effects and drastically improving efficacy. Our UNIQUE GEL PLATFORM -SRGel- is the 1st non-aqueous solvent-free injectable gel platform compatible with more than 90% of the oncology drugs and easy to place or apply anywhere in the body, enabling local and concentrated treatment directly inside the tumor. Our 1st formulation, TumoCure (SRGel+Cisplatin), faces the unmet medical need of HNC patients, especially those 300,000 (30%) who are inoperable and unfit for chemotherapy. TumoCure proved clinically efficacious in 8 patients who have exhausted all lines of treatment (options)–patients with no hope. All patients benefited from tumor shrinkage or necroses, including 3 complete response – 100% shrinkage (elimination) of the tumor, without experiencing any side effects, which extended their overall survival and quality of life. Our roadmap starts with HNC because of its unmet medical need. We will follow with glioblastoma - an orphan disease. Intragel can be readily scaled up for new indications of TumoCure and for developing new formulations with other drugs. For patients with inoperable and untreatable tumors, TumoCure constitutes the only LIFE-SAVING OPPORTUNITY. EIC support will accelerate the clinical validation and commercialization of TumoCure, providing a global impact on healthcare systems, clinicians, and patients.

Keywords: minimally invasive,interventional oncology,long acting,solvent free,hydrophobic,local drug delivery,antitumoral,cancer,head and neck cancer,biodegradable,drug compatibility,injectable
CLimAte riSk implicationS for fInance and the real eConomy (CLASSIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Austria,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 2
Project status: SIGNED

CLASSIC (CLimAte riSk implicationS for fInance and the real eConomy) intends to contribute to understanding how physical and transition climate risk impact the financial system and the real economy by quantifying the linkages and feedback between the two. There is consolidated evidence on the significant impacts of climate change on the real side of the economic systems. However, a much narrower, even though expanding, research has been done on the financial implications of climate risk. Identifying the source, transmission channels, direction and magnitude of these impacts is of primary importance to policymakers, the business and finance community for a decision-making robust to climate risk effects on the global capital markets. CLASSIC contributes to understanding how physical and transition climate risks impact the financial system and the real economy by quantifying the linkages and feedback between the two. The project investigates the economic and financial impacts of physical climate risk and of transition risk posed by climate change mitigation policies in the context of the EU Green Deal and the EU fit for 55 policies. Methodologically, an integrated modeling framework is built by coupling the macroeconomic representation of the real side of the economy with the financial side. The multi-sector multi-country Computable General Equilibrium model ICES (Intertemporal Computable Equilibrium System) model describes the former, while a climate financial risk module represents the latter. The applicant works with highly skilled, leading partners who join forces to achieve the strategic objectives of CLASSIC. The partners’ scientific excellence with their long teaming traditions provides a first-class environment for training and research. The ambitious plan for generation of impact and dissemination of outcomes paves the way to creating policies for effective targeting of climate risk and enables the creation of a new service for climate risk hedging.

Keywords: climate risk,physical climate risk,transition climate risk,cge modeling,financial system modeling,climate finance,climate finance modeling,net zero transition
Fighting with a Smile: Satirical and Humourist Voices of Resilience from Hindi Speaking Subaltern Subjects and Communities (FISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,India
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 230352.0
EU funding (EUR): 230352.0
Participants: 2
Project status: SIGNED

The project aims to be the first attempt at investigating the forms, uses and functions of Hindi contemporary humour (hasya) and satire (vyangya). By moving towards this direction, it will focus especially on the connection of Hindi satire with the claims by the subaltern and marginalized subjects and communities of Hindi contemporary public sphere. It must be outlined that the terms subaltern and marginalized will refer not only to the Adivasi - framed by Indian constitution as the 'tribals' of India - and to the Dalit - better known as the 'outcaste' people - but also to the LGBTQIA+ and to the discriminated women in India. In the light of the above, the main objective of the research is to shed light on the narratives of dissent pursued by these subjects and communities. It will also analyse the contribution of Hindi satirists and humourists to specific socio-cultural and political claims and initiatives. Finally, it will investigate the use of satire and humour as a personal and collective forms of resilience. To achieve these set goals, the project surveys in a interdisciplinary way many fields in which satire can be detected. Primarily, it focuses on the use of satire in Hindi contemporary literature. In this field the research highlights the contribution of Surya Bala, usually deemed as the first Hindi woman literary satirist. Other less famous marginalized literary contemporary satirists will be equally taken into consideration. Moreover, it must be stressed that, apart from the literary side of satire, the project will investigate also the 'life' beyond literature of satire. In this field, it will focus primarily on the performative uses of satire and humour during the Hasya kavi sammelan (Meeting of humorist poets) which are usually held in many parts of North-India and the shows by stand-up comedians.Other less known performative uses of satire will be taken into consideration. The research will also outline the uses of satire and humour on new media.

Keywords: hindi public sphere,marginalized subjects and communities,satirical activism,satire as performance,humour