Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Imaging NM: A Nanoparticulate Precision Medicine Approach to Target Cancer (INTACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Netherlands
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2020-06-30
Duration (months): 35.0
Total project cost (EUR): 5818516.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Cristal Therapeutics (CT) develops the next generation of nanomedicines to treat cancer. Cancer remains one the leading causes of death worldwide, and current treatment options are insufficient, in part due to the tumour heterogeneity between patients. CT has developed state-of-the-art nanoparticles (CriPec®) to target a drug of choice more selectively to the tumour site(s). The superior therapeutic performance of this approach has already been demonstrated preclinically for CT’ lead product CriPec® docetaxel and a promising clinical phase I trial is finalizing, providing a significantly increased pharmacokinetic and safety profile. CT already observed activity in patients and much reduced neutropenia and alopecia. In INTACT, CT will perform phase II clinical trials in ovarian and bladder cancer to evaluate the therapeutic efficacy of CriPec® docetaxel. Furthermore, CriPec® docetaxel will be decorated with a PET tracer (89Zr), which enables oncologists to visualize CriPec® biodistribution in real-time. Tumour uptake will be correlated with therapeutic responses and result in parameters for future patient selection. This approach turns the drug into a personalized medicine whereby only those patients that exhibit enhanced tumour-targeting will be treated. This personalisation assures maximum efficacy in selected patients, avoids exposing patients to inappropriate drugs and adverse effects, and allows patients with limited tumour targeting to receive other more appropriate treatment. CT will use INTACT to close the gap from lab to market and facilitate a licensing deal for CriPec® docetaxel, projected to generate revenues exceeding >€100M in 2024. More importantly, INTACT will validate the CriPec® nanomedicine platform, boost product development for other diseases through licensing deals, and provide a growth of 10FTE by 2022. Success in INTACT will truly launch Cristal Therapeutics’ business.

Keywords: nanomedicine,cancer,imaging,companion diagnostic
Identification of physiological and molecular mechanisms mediating the response of Nitrogen nutrition to eCO2 (NUTRIENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The continuous elevation of atmospheric CO2 concentration will lead to levels higher than 750 ppm at the end of the century. Such elevated atmospheric CO2 (eCO2) will impact the biology of most plants, as CO2 is a limiting factor for C3 photosynthesis. While it is predicted that eCO2 will increase biomass production in C3 plants, many studies suggest that this is actually lower than expected. In addition eCO2 impairs the mineral status of these plants, especially for nitrogen (N) and iron. This is now acknowledged as an under evaluated threat for human nutrition, as deficiencies in proteins and micronutrients are already serious health problems affecting about two billion people. The key issue addressed by NUTRIENT is to understand why eCO2 has a detrimental effect on mineral nutrition of C3 plants. This effect is not understood, but recent studies indicate that eCO2 may negatively affect physiological and/or developmental processes involved in nutrient acquisition, translocation and assimilation. This highlights a major knowledge gap on the coordination between photosynthesis and mineral nutrition in response to eCO2. NUTRIENT will tackle this issue by focussing on the effect of eCO2 on N nutrition in Arabidopsis thaliana, with the aim to identify physiological and molecular mechanisms that underlie the negative effect of eCO2 on plant proteins content. This will be achieved using an integrative systems biology approach, combining physiological and molecular analyses of N nutrition, characterisation of transport, metabolism or signalling mutants, and modelling of gene regulatory networks from transcriptomic studies. Arabidopsis is a perfect model as it shows the same negative effect of eCO2 on nutrient status as C3 crops, and offers many genetics, genomics and bioinformatics resources. NUTRIENT has great potential to contribute to Europe’s excellence and competitiveness in the world, being in line with the European and French Sustainable Development programs.

Keywords: climate change,phenomics,plant nutrition,arabidopsis thaliana
Virtual Coaching Activities for Rehabilitation in Elderly (vCare)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Austria,Germany,Spain,Spain,Germany,Romania,Belgium,Denmark,Denmark
Call: Personalised coaching for well-being and care of people as they age (H2020-SC1-2017-CNECT-1, 2017)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 4044217.05
EU funding (EUR): 4044217.05
Participants: 16
Project status: CLOSED

One out of six people in the European Union has a disability, usually caused by an acute episode or a chronic disease. Providing a suitable rehabilitation is the main issue for people as they age as it helps people to live independently and enhance their Quality of Life. However, as the rehabilitation period usually last some months, the continuity of care often is interrupted in the transition from the hospital to the home. Virtual Coaches can help these patients to proceed with a personalized rehabilitation that complies to age-related conditions, as the key technology for empowering patients through the enhancement of the adherence to the care plan and the risk prevention. The project “vCare” (Virtual Coaching Activities for Rehabilitation in Elderly) addresses two major shortcomings of the status quo: a participatory design driven by users’ needs and the personalization of the care pathways enabled by technology. In fact that rehabilitation is an ideal setting as “users” (physicians and patients) interact together for a “long” period into the clinic (from two weeks to two months): this is a good opportunity to embed into the knowledge of the system the clinical profiles and the pathways that will drive the behaviour of the virtual coach at home. Well-elaborated services for tele-rehabilitation of former EU projects, such as eWall or Miracolus Life, will be adapted. Therefore, the system will integrate a semantic layer (universAAL) including a reasoning engine that merges all patient-related and context information together. The advanced services of vCare will be deployed on a reference platform of MYSPHERA (FIWARE-based) and implemented in four reference sites, dealing with commonly impacted domains (neurological and cardiological). The results of vCare shall stimulate the European Healthcare & ICT sector for innovations in the field of integrated care. In sum, vCare will contribute to the EU goal to increase healthy life years of Europeans by two until 2020.

Keywords: patient empowerment,personalized rehabilitation,virtual coach
A novel, cost-, time- and energy-efficient, electric hammer to replace the traditional hydraulic hammer (LEKAEH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The LEKAEH innovation project aims to bring to market a novel, energy-efficient, electric hammer as a replacement to the traditional hydraulic hammer (also known as a hydraulic breaker). The product is supporting the electric transformation trend of construction and mining machines. The innovation saves up to 75% energy, is more verstaile in use, has higher performance values and is more environmentally friendly. All this is possible due to electric transformation in the mentioned segment. We are no more limited to use only hydraulics as high power level energy source. Instead, high power levels of electricity are available in hybrid and all electric machines. In this feasibility study of the SME Phase I project Lekatech aims firstly to build co-operation with potential future customers and define its position within the value chain of construction and mining machine sector. Secondly Lekatech aims to continue its technical feasibility work and reach the next milestone, the design of commercial prototype that builds on the current technology prototype. Thirdly Lekatech intends to improve the quality of its overall business plan, especially in relation to differentiating between and evaluating the most attractive primary business strategy and the second most attractive strategies that are to be considered as backups and expansion opportunities for the future. This innovation project is essential in paving the path to commercializing this disruptive technology. This project is targeted to prepare the company for successful application to Phase II as next. Lekatech Oy was founded solely to commercialize this novel technology and its success is measured only by its performance in this.

Keywords: construction equipment,mining equipment,demolition equipment,rock breaking,linear motor,pm motor,attachment,energy saving,linear motion,low energy,programmable
Metal-Foldamer Porous Frameworks (MFPFs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-10-14
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: TERMINATED

The design and precise construction of protein-inspired nanostructures through folding and metal-directed self-assembly is a challenging yet potentially rewarding endeavor for the development of new classes of functional materials. Peptides have been well established as flexible starting points for the construction of bioinspired architectures with a high level of sophistication and precise control over morphologies and functions. Concurrently, the power of metal coordination to drive assembly has been extensively explored to design functionally versatile metal-organic frameworks (MOFs). Yet, the synthesis of such coordination networks by a process that would combine folding, self-assembly and metal coordination in aqueous media is still partially unaccomplished. Foldamers - artificial synthetic folded oligomers - possess the advantages of structural robustness and high programmability which bodes well for their use in the construction of well-defined higher-order nanostructures. The project will move a step forward towards the design, synthesis and structural characterization of metal-foldamer porous frameworks and will focus on foldamer sequence evolution and metal variation to influence the main features of the assembly (shape and catalytic property). The applicant has been trained in peptide synthesis and has acquired a high level of expertise in the design and structural characterization of peptide-based assemblies and advanced materials. He will join and bring his expertise to a host laboratory that has pioneered the design of oligourea-based foldamers as peptide mimics. Secondment in an internationally renowned group in the chemistry of metalloenzyme active sites and the design of bio-inspired catalysts will provide the appropriate combination of knowledge required for this multidisciplinary study. This project represents a significant leap forward in the creation of a whole new range of fully synthetic and functional higher-order foldamer nanostructures.

Keywords: foldamer chemistry,folding,helices,protein inspired assemblies,metal coordination,hydrolytic activity,biocatalysis,host guest interactions,porous framework,self assembly
Integrated solar heating and cooling unit based on a novel zeolite chiller and heat pump (ZEOSOL)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Italy,Germany,Germany,Greece,Greece
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-06-01
End date: 2020-02-29
Duration (months): 33.0
Total project cost (EUR): 2741375.0
EU funding (EUR): 2167437.5
Participants: 5
Project status: CLOSED

The overall objective of this project is to develop a new advanced solar cooling and heating product, using advanced heat exchanger technology and integrating a heat pump for covering peak demand. This new product is based on the further improvement and integration of the products already commercialized by Fahren and Akotec. It uses synergies between the technologies of thermal chillers (heat to cooling technology) and heat pump (electricity to cooling technology) and combines know-how on design and manufacturing of adsorption chillers and solar thermal collectors in Germany, with the know-how in heat pump and dry cooling systems of CNR and NTUA. The main innovation of the project is the adsorption chiller unit based on Fahren’s patented zeolite coating technology, reducing the unit’s volume and cost by about two times. This new product is expected to become cost-effective and with high flexibility for providing both cooling (during summer) and heating (during winter) from the same compact product, being more competitive than existing mainstream solution, reducing energy costs of the end-users and leading to short ROI. The main target market is the heating, ventilation and air-conditioning (HVAC) market, with the ambition to become front-runners and provide the first cost-effective product, with low maintenance requirements. The target cost is to reach just 2000 €/kW (with solar field and cooling, heating and thermal storage included) and secure a short return on investment. The new product will be commercialized by a new joint venture established between Fahren and Akotec with Diadikasia being a strategic partner for promotion and sales in south Europe. The initial target markets are in Greece, Italy and Germany, while further expansion steps will follow once sales increase.

Keywords: adsorption chiller,zeolite,solar thermal,cooling and heating,heat pump,compact product
DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics (Dementia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models. Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for prevention and/or therapy. This proposal addresses a huge unmet medical need worldwide, which seriously affects QoL, challenges health care systems, and offers unprecedented socio-economical opportunities.

Keywords: dna damage,aging,alzheimer
INL Fellowship programme in nanotechnologies for nanomedicine, energy, ICT, food and environment applications (NanoTRAINforGrowthII)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-FP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 3398400.0
EU funding (EUR): 1699200.0
Participants: 1
Project status: CLOSED

The NanoTRAINforGrowth II is the International Iberian Nanotechnology Institute’s (INL) fellowship programme for Experienced Researchers (ER). It is set to be a 5 year programme and is a 2nd edition of INL´s fellowship programme. It´s main objective is to attract talented researchers and provide opportunities for training and career development, at a one of a kind and state of the art research infrastructure. Selected fellows will have the opportunity to work at INL, through a two-year employment contract, which is the first (and so far the only) research organization in Europe, with an international legal status, entirely focused in the field of nanoscience and nanotechnology. INL´s Post-doc fellowship programme is an individual-driven bottom-up approach that comprises the incoming mobility scheme. INL´s international post-doctoral fellowship programme allows for experienced researchers (from all over the world and nationality) to sketch out a research project and work on their own research idea, at INL´s Facilities. Fellows will have access to a completely brand new set of state-of-the-art equipment and will have the opportunity to enhance their expertise via a research project, in a scientific topic of their choice, and that is well within INL´s strategic research and technological development areas.

Keywords: nanotechnology,training,postdoctoral,international,fellowships,career development,interdisciplinary,health,food,environment,energy
Aerosol and Climate Response to NH3 in the NMMB/BSC Inter-Scale Model (ACRoNNIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-12
End date: 2019-09-11
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Atmospheric particulate matter reduces visibility, adversely affects human health and impacts Earth’s climate. Recent laboratory research has identified NH3 as a potentially important reactive species in the formation and aging of SOA, a significant but not-well-quantified class of aerosol particles. The goal of this proposal is to answer the questions: How does NH3 affect aerosol mass loadings and optical properties on a global scale? And, what impact do these effects have on air quality and climate? This will be accomplished by incorporating NH3-related SOA chemistry, currently being investigated by collaborators at the University of California, Irvine (UCI) into the state-of-the-art CACM/MPMPO SOA module. The updated module will be deployed in the NMMB/BSC global chemical weather model, maintained at the Barcelona Supercomputing Center (BSC). Model predictions will be validated by field measurements collected during an IDAEA-CSIC campaign that the experienced researcher (ER) will participate in, as part of this proposal. This will result in one of the most advanced SOA treatments available in global models, and allow an investigation of the impact of NH3 on global SOA, air quality and climate, thus directly impacting a crosscutting issue of the Horizon 2020 Program, climate action. The ER has experience using laboratory results to develop mechanisms for aerosol processes, and in the development of CACM/MPMPO as a graduate and postdoctoral researcher at UCI. This experience, coupled with training in global model development at BSC, will provide ideal conditions to successfully execute this proposal, and strengthen the collaboration between the European BSC and IDAEA-CSIC, and US-based UCI teams. By the end of the Fellowship, the ER will have hands-on experience in field, laboratory and computational aerosol research, uniquely positioning him to develop and carry out comprehensive, collaborative research initiatives and opening up improved career opportunities.

Keywords: secondary organic aerosol,ammonia,atmosphere,global model,nmmb,cacm,mpmpo