Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Agenda for Research on Chernobyl Health (ARCH): to develop of a Strategic Plan for Research on the Health Consequences of Radiation from the Chernobyl Accident. (ARCH)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Fission/fusion cross-cutting actions
Destination: Cross-Cutting Actions
Action type: Coordination and support actions
Countries involved: France,Spain,Germany
Call:  (FP7-Fission-2007, 2007)
Start date: 2008-11-01
End date: 2010-10-31
Duration (months): 24.0
Total project cost (EUR): 362907.0
EU funding (EUR): 206356.0
Participants: 3
Project status: CLOSED

The Chernobyl accident led to the most serious exposure of a normal human population to ionising radiation, apart from the atomic bombings in Japan. Unlike the bombing, the health impact of Chernobyl has not been comprehensively studied. In some areas (eg thyroid cancer), research has been intensive and informative; in others, little work has been conducted. The validity of extrapolating radiation risk estimates mainly based on atomic bomb studies to exposures of public health concern is controversial. Questions relate to the choice of models for transport of risk between populations; projection of risk over time; extrapolation of risks from external high dose-rate exposure to low dose and low dose-rate exposures from internal radiation. Questions also concern non-cancer risks and the importance of non-targeted effects following low levels of radiation. Chernobyl has an iconic status in the public eye, and the accident provides a unique opportunity to answer these questions, to provide the authoritative studies needed to inform the nuclear debate, and to test novel hypotheses about radiation effects and biology/genetics in general. Because the range of potential studies is so vast, this proposal is for the development of a strategic research agenda on the health consequences of radiation exposure from the Chernobyl accident. The modus operandi will be the assembly of a multidisciplinary group of experts, from within and outside the most affected states, who have considerable experience in the follow-up of the health consequences of the accident. The group will identify and prioritise (short and longer-term) the potential studies, assess their feasibility, cost effectiveness and likelihood of success, and provide a reasoned and comprehensive strategic agenda for future research. The strategic research agenda will be provided within 18 months; detailed proposals for short-term priority research topics will be provided within 9 months.

Keywords: chernobyl,health,low-doses,research agenda,internal exposure,cancer,non-cancer,non-targeted effects
Computer-aided food processes for control engineering (CAFE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Belgium,France,Spain,Belgium,Italy,United Kingdom,France,Netherlands,France,Netherlands,Spain,Czechia,Belgium
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-06-01
End date: 2013-02-28
Duration (months): 57.0
Total project cost (EUR): 7327137.33
EU funding (EUR): 5340452.0
Participants: 17
Project status: CLOSED

The objective of the CAFE project is to provide new paradigms for the smart control of food processes, on the basis of four typical processes in the areas of bioconversion, separation, preservation and structuring. The novelty of the project lies in the capacity of combining PAT and sensing devices with models and simulation environment with the following objectives : (1) to extract as much as possible information from the process/plant in the form of precise estimations of unmeasured variables defining, in particular, product quality, and of physical parameters changing as the process dynamics does or difficult to know beforehand; (2) to save and encode in a reliable and usable way, basically via physical/deterministic models; and (3) to develop control methods to keep uniform quality and production despite the variability in the raw material and/or to respond to sudden changes in the demand.

Keywords: process control,pat,sensors,monitoring,optimization,data management,freeze-drying,cristallization,bioconversion
Systems Biology as a Driver for Industrial Biotechnology (SYSINBIO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Coordination and support actions
Countries involved: Sweden,Denmark,Finland,Switzerland,Germany,Netherlands,Italy,Portugal,Germany,Germany,Sweden,Türkiye,Denmark,Germany,Germany,France
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-12-01
End date: 2011-11-30
Duration (months): 36.0
Total project cost (EUR): 1485204.0
EU funding (EUR): 996545.0
Participants: 21
Project status: CLOSED

Metabolic engineering is an applied science focusing on developing new cell factories or improving existing ones. Metabolic engineering is an enabling science, and distinguishes itself from applied genetic engineering by the use of advanced analytical tools for identification of appropriate targets for genetic modifications and the use of mathematical models to perform in silico design of optimized cell factories. In recent years, there has been increasing focus on using mathematical models for design. SYSIBIO will coordinate European activities in the field of model driven metabolic engineering and also coordination of activities on other technologies required for state of the art metabolic engineering, e.g. metabolomics and fluxomics. The coordination of activities will involve establishing a database containing metabolic models for different industrially important microorganisms. The database will also contain different simulation tools required for use of these models to identify metabolic engineering targets and use of these models for analysis of omics data. SYSINBIO will also coordinate the further development of techniques required for metabolic engineering, such as metabolomics, fluxomics and identification of mutations in evolved strains. Furthermore, an important part of SYSINBIO will be coordination of education and training in the field of metabolic engineering in Europe.

Keywords: metabolic engineering,metabolomics,fluxomics,industrial biotechnology
Future Crops for Food, Feed, Fiber and Fuel (4F CROPS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Coordination and support actions
Countries involved: Greece,Italy,Germany,Italy,Spain,Romania,Poland,Netherlands,Poland,Portugal
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-06-01
End date: 2010-11-30
Duration (months): 30.0
Total project cost (EUR): 1264380.3
EU funding (EUR): 994382.0
Participants: 13
Project status: CLOSED

As different sectors – food, feed, fiber, and fuels – compete for land, the yielding potential of the future non-food crops has to be as efficient as possible in order to minimize the competition for land. The main objective of the proposed 4F CROPS is to survey and analyse all the parameters that will play an important role in successful non-food cropping systems in the agriculture of EU27 alongside the existing food crop systems. The work will start (WP1) with the prediction of the future land use in short term (2020) and long term (2030), taking under consideration restrict factors for agriculture and the market demand for non-food crops. The cropping possibilities (WP2) based on regional potential levels, ecology and climate will be determined. This group of non-food crops will be then subjected to a comparative cost analysis with conventional crops (WP3) for the same time framework. Socio-economic impacts, like farmers’ income, rural development, public development, and public acceptance will analyse. Then environmental implications will be assessed compared to their respective conventional products (fossil energy, conversional materials) (WP4). Several environmental impacts will be assessed like soil quality and soil erosion, air quality and climate change, water issues, biodiversity and landscape by using LCA and EIE methods. The regulatory framework of the non-food crops will be considered including existing policies, co-existence and safety measures when the crops used for both food and non-food crops (WP5). The work from WP1 – WP5 will be used for the formation of scenarios for successful non-food cropping alongside food cropping systems (WP6) answering whether a completive bioeconomy is a viable option for EU27. The dissemination (WP7) will be done though the web-site (intranet), the four project workshops and other articles, leaflet, conferences, fact sheets, and links. WP8 aims at the coordination, management and reporting of the project.

Keywords: non-food crops,biofuels,biomaterials
Science Created by You (SCY) (SCY)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Digital libraries and content
Action type: Collaborative project
Countries involved: Netherlands,Norway,France,Germany,Germany,Cyprus,Estonia,Canada,Netherlands,Netherlands
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-03-01
End date: 2012-02-29
Duration (months): 48.0
Total project cost (EUR): 8146812.0
EU funding (EUR): 5999073.0
Participants: 12
Project status: CLOSED

Science Created by You (SCY) will deliver a system for constructive and productive learning of science and technology. SCY uses a flexible and adaptive pedagogical approach to learning based on “emerging learning objects” (ELOs) that are created by learners. In SCY-Lab (the SCY learning system) students work individually and collaboratively on “missions” which are guided by a general socio-scientific question (for example “how can we produce healthier milk?”) and fulfilling the mission requires a combination of knowledge from different domains (e.g., physics and mathematics, or biology and engineering). While on a SCY-mission, students perform several types of learning actions that can be characterised as productive (experiment, game, share, explain, design, etc.), students encounter multiple resources, they collaborate with varying coalitions of peers, and they use changing constellations of tools and scaffolds (e.g., to design a plan, to state a hypothesis etc.). The configuration of SCY-Lab is adaptive to the actual learning situation, advising students on appropriate learning actions, resources, tools and scaffolds, or peer learners that can support the learning process. The SCY project aims at students between 12-18 years. A total of five concrete SCY-missions will be developed. The SCY approach is enabled by the innovative architecture of SCY-Lab that supports the creation, manipulation, and sharing of ELOs (models, data sets, designs, plans, etc.). The central unit in the SCY architecture is a broker that configures SCY-Lab to unfolding learning processes and activities. For this it uses information from pedagogical agents that exploit techniques of educational data mining to monitor information in the SCY repository that stores the ELOs as well as domain information, the log-files of student behaviour, and the recorded chats between students.

Keywords: science and technology learning,inquiry learning,collaborative learning,mobile learning,productive learning,emerging learning objects
PROcedures for TESTing and measuring wind energy systems (PROTEST)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Netherlands,Greece,Belgium,Germany,Germany,Germany,Germany
Call:  (FP7-ENERGY-2007-1-RTD, 2007)
Start date: 2008-03-01
End date: 2010-08-31
Duration (months): 30.0
Total project cost (EUR): 2675619.0
EU funding (EUR): 1980119.0
Participants: 7
Project status: CLOSED

One of the major causes of failures of mechanical systems (e.g. drive trains, pitch systems, and yaw systems) in wind turbines is insufficient knowledge of the loads acting on these components. The objective of this pre-normative project is to set up a methodology that enables better specification of design loads for the mechanical components. The design loads will be specified at the interconnection points where the component can be &quot;isolated&quot; from the entire wind turbine structure (for gearboxes for instance the interconnection points are the shafts and the attachments to the nacelle frame). The focus will be on developing guidelines for measuring load spectra at the interconnection points during prototype measurements and to compare them with the initial design loads. Ultimately, the new procedures for the mechanical components will be brought at the same high level as the state-of-the-art procedures for designing and testing rotor blades and towers which are critical to safety. A well balanced consortium, consisting of a turbine manufacturer, component manufacturer, certification institute, and R&amp;D institutes will describe the current practice for designing and developing mechanical components. Based on this starting point, the project team will draft improved procedures for determining loads at the interconnection points. The draft procedures will be applied to three case studies with each a different focus, viz. determining loads at the drive train, pitch system, and yaw system; the latter one taking into account complex terrain. The procedures will be assessed by the project team and depending on the outcome the procedures will be updated accordingly and disseminated. All partners will incorporate the new procedures in their daily practices for designing turbines and components, certifying them, and carrying out prototype measurements. Project results will be submitted to relevant standardisation committees.

Keywords: wind energy mechanical loads reliability drive train standards measurements
Prospective cohort studies of children with substantial medical diagnostic exposure (CHILD-MED-RAD)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radiation protection
Destination: Radiation Protection
Action type: Coordination and support actions
Countries involved: France,Finland,Sweden,United Kingdom,France,Denmark,Netherlands,Germany,Spain
Call:  (FP7-Fission-2007, 2007)
Start date: 2008-09-01
End date: 2009-11-30
Duration (months): 15.0
Total project cost (EUR): 361022.4
EU funding (EUR): 279931.0
Participants: 9
Project status: CLOSED

The growing use of diagnostic X-rays and of high-dose techniques (CT, interventions) in children and adolescents is a topic of concern in radiological protection. Studies of other populations indicate that children are generally more sensitive to health effects of radiation than adults. In addition, children have a longer life-span to express any radiation-related health effect and, because of their smaller mass children, may receive higher doses to specific organs from these procedures if examination protocols are not adapted. Procedures of particular concern include: the use of CT in children (which delivers doses that are substantially greater than those from conventional X-rays); interventional cardiology, in which fluoroscopy is used to guide small instruments such as catheters through blood vessels (which, if repeated, can deliver doses of several hundred mGy to specific organs); and the use of repeated X-rays for monitoring respiratory, cardiac and digestive pathologies in premature babies (for repeated procedures, cumulative doses range up to a few mGy – and premature babies could be particularly sensitive to radiation induced diseases). Because the health effects of these low doses of radiation are expected to be relatively small, trans-national collaborative studies are needed to ensure sufficient statistical power to study these effects. In this project we seek support to assemble a critical mass of scientists involved in the study of medical radiation exposures and health effects of radiation dispersed throughout Europe with the aim of: ● Assessing the feasibility of establishing prospective trans-national cohorts suitable for long term follow up (including evaluation of the statistical power of the study) ● If the feasibility is demonstrated: - Making recommendations for future research needs including populations suitable for long term follow-up; - Developing specific project proposals, including study protocols and procedures for follow-up.

Keywords: children,medical radiation,cts,cancer,non-cancer outcomes,premature babies,interventional cardiology
Developmental effects of environment on reproductive health (DEER)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Collaborative project
Countries involved: Finland,Denmark,United Kingdom,Spain,France,Bulgaria,Denmark,United States,France
Call:  (FP7-ENV-2007-1, 2007)
Start date: 2008-05-01
End date: 2012-04-30
Duration (months): 48.0
Total project cost (EUR): 4615781.8
EU funding (EUR): 3499028.0
Participants: 9
Project status: CLOSED

The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management.

Keywords: reproductive health,environment,development,endocrine disruption,gene-environment interaction,toxicogenomics,proteomics,metabolomics
HEalth Risk from Environmental Pollution Levels in Urban Systems (HEREPLUS)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Coordination and support actions
Countries involved: Italy,Germany,European organisations area,Greece,Spain,Serbia,United Kingdom
Call:  (FP7-ENV-2007-1, 2007)
Start date: 2008-09-01
End date: 2011-05-31
Duration (months): 33.0
Total project cost (EUR): 1683052.0
EU funding (EUR): 1399836.55
Participants: 10
Project status: CLOSED

HEREPLUS will: 1) involve coordination among epidemiologists, biostatisticians, environmental scientists, GIS specialists in order to realize the full potential of GIS technology in environmental health research; 2) develop risk maps relating to human health, and O3 and PM concentrations using the ArcGis approach, taking into account existing and validated epidemiological models, for selection of important and problematic large European urban areas such as Rome, Madrid, Dresden, Athens; 3) improve the knowledge of the potential role of different urban vegetation types for mitigating the O3 and PM pollution levels, and provide best practices regarding the selection of no-VOCs emitting species and management of large green areas located in different neighbouring urban areas; 4) furnish guidelines for municipal managers and administrators deputed to establish urban-environmental measures which combine risk maps, urban vegetation as a sink for ozone and PM, and minimization of sanitary costs, all based on results and knowledge achieved by the project activities as a whole. These guidelines will take the form of best practices recommendations and designs for municipal laws that may be used as a base-line for municipal administrations; 5) disseminate guidelines and best practice indications at a European level, through international workshops and a conclusive report. Specific cardio-respiratory disease, such as asthma, bronchitis, COPD exacerbation, ischemic heart disease, and the morbidity and mortality for these diseases, associated to O3 and PM, will be considered in HEREPLUS. HEREPLUS will produce the above mentioned risk maps starting from pre-existent environmental and health data, by development of new epidemiological and statistical approach, also in support for the implementation of Global Earth Observation System of Systems (GEOSS) initiative and the Environment and Health Action Plan.

Keywords: metropolitan areas,human health,cardio respiratory diseases,ozone,particulate matter,epidemiology,gis,statistical approaches,urban green,risk maps.