Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coupled climate and Greenland ice sheet evolution:past, present and future (CoupledIceClim)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 1677282.0
EU funding (EUR): 1677282.0
Participants: 1
Project status: CLOSED

The Greenland ice sheet (GrIS) is losing mass at an increasing pace, in response to atmospheric and ocean forcing. The mechanisms leading to the observed mass loss are poorly understood. It is not clear whether the current trends will be sustained into the future, and how they are affected by regional and global climate variability. In addition, the impacts of Greenland deglaciation on the local and global climate are not well known. This project aims to explain the relationship between GrIS surface melt trends and climate variability, to determine the timing and impacts of multi-century deglaciation of Greenland, and to explain the relationship between ongoing and previous deglaciations during the last interglacial and the Holocene. For this purpose, we will use the Community Earth System Model (CESM), the first full-complexity global climate model to include interactive ice sheet flow and a realistic and physical-based simulation of surface mass balance (the difference between surface accumulation and losses from runoff and sublimation). This tool will include for the first time a large range of temporal and spatial scales of ice sheet-climate interaction in the same model. Previous work has been done with oversimplified and/or uncoupled representations of ice sheet and climate processes, for instance with simplified ocean and/or atmospheric dynamics in Earth System Models of Intermediate Complexity, with fixed topography and prescribed ocean components in Regional Climate Models, or with highly parameterized snow albedo and/or melt schemes in General Circulation Models. This project will provide new insights into the coupling between the GrIS and climate change, will lead widespread integration of ice sheets as a new and indispensable component of complex Earth System Models, and will advance our understanding of present and past climate dynamics.

Keywords: earth system modelling,climate change,ice sheets,surface mass balance,climate dynamics,paleoclimate,ice climate feedbacks
Integrated and Detailed Image Understanding (IDIU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2021-07-31
Duration (months): 72.0
Total project cost (EUR): 1497271.0
EU funding (EUR): 1497271.0
Participants: 1
Project status: CLOSED

The aim of this project is to create the technology needed to understand the content of images in a detailed, human-like manner, significantly superseding the current limitations of automatic image understanding, and enabling new far reaching human-centric applications. The first goal is to substantially broaden the spectrum of visual information that machines can extract from images. For example, where current technology may discover that there is a ``person'' in an image, we would like to produce a description such as ``person wearing a red uniform, tall, brown haired, with a bayonet, and a long black hat.'' The second goal is to do so efficiently, by developing integrated image representations that can share knowledge and computation in multiple computer vision tasks, from detecting edges to recognising and describing thousands of different object types. In order to do so, we will investigate, for the fist time in a systematic manner, the breadth of information that humans can extract from images, from abstract patterns to object parts and attributes, and we will incorporate it in the next generation of machine vision systems. Compared to existing technology, the new algorithms will have a significantly richer and more detailed understanding of the content of images. They will be learned from data building on recent breakthroughs in large scale discriminative and deep machine learning, and will be delivered as general-purpose open-source software for the benefit of the research community and businesses. In order to make these systems future-proof, we will develop methods to extend them automatically, by learning from images downloaded from the Internet with very little human supervision. These new advanced capabilities will be demonstrated in breakthrough applications in large scale image search and visual information retrieval.
Research capacity building through improved knowledge exchange and twinning frameworks for the Centre of Excellence in Translational Medicine (CETM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Sweden,United Kingdom
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1072437.5
EU funding (EUR): 1072437.5
Participants: 3
Project status: CLOSED

The project will enhance Estonian research potential and capacities in translational medicine with particular focus on immunological diseases and neurological disorders, which represent a challenging burden on individuals and healthcare systems worldwide. Strategic partnership with UCL and KI - both international leaders in medical research and education, enables developing long-lasting knowledge exchange framework for allowing University of Tartu (UT) to capitalise on its current achievements and deliver a new internationally-leading European Centre of Translational Medicine (CETM). The specific objectives of the project are to: 1. measurably and significantly enhance the overall scientific R&I capacity of UT and Estonia in the field of translational medicine 2. raise the research profile of academic staff 3. strengthen UT´s networking capacity, visibility and credibility In order to achieve these objectives, the twinning activities with UCL and KI will: - create a strategic framework for sustainable development (long-term development plan, links with industrial partners, public funding and investment strategy, IPR strategy) - enhance UT´s research capacity in 6 key areas/techniques (6 joint summer schools/seminars, 11 medium-term visits, 38 short bidirectional visits, participation in conferences) - develop transferable skills of UT´s research staff (training seminars in networking/H2020 participating, IPR, research commercialisation, ethics, communication skills and doctoral training) - extend UT´s strategic partnerships and visibility among the professional community, industry, policy-makers and public (strategic networking, publications, science days, open workshops, targeted stakeholders) As the expected result of the CETM-TWIN project, the twinning activities between the consortium will lead to research improving synergy that supports building one of the leading translational medicine competency centres in the North-Eastern European region by 2020.

Keywords: translational medicine,twinning,neurodegenerative diseases,autoimmune diseases,neuroimmunology
Smart Shoot Remover (SSR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Removal of green shoots is a key step in vineyards and fruit trees, to control growth and improve production and quality of fruits. Shoots that grow on sides of the stems cause the plant to produce smaller fruits that may not ripen properly. By removing green shoots, plant produces better quality fruits (colour, size, ripening and weight) as sap concentrates flow in the growing areas. Current options to remove shoots are: (a) by hand: which force the worker to operate in a position that leads to injuries; (b) use of scissors: posing a high risk of spreading diseases/pests through sap with important drawbacks; (c) with a battery/fuel powered mechanical equipment: that implies high costs in terms of fuel consumption and equipment and can damage young stems; and (d) by chemicals application: that releases toxic products through herbicides. SSR (Smart Shoot Remover) is an innovative tool to quickly and completely remove green shoots from stems/trunks. It consists of two opposed interchangeable brushes, clamped around the stem/trunk and held via a guide system, which opens out the brushes in an adjustable angle, and a non-sharp blade, attached to one of the brushes guides, to remove the shoots by stripping, without damaging the plant. SSR allows to work 40% faster than manual techniques, saving 2.2 hours of workday vs. manual technique. It cost 98% less than mechanical equipment, requires only 1 operator against 2 of the mechanical/chemical removal and does not use fuel nor motorised equipment, reducing operational costs in >60€/h, and emissions. It reduces risk of spread of trunk diseases (ie. Esca complex), and improves of worker’s safety and ergonomics by preventing back injuries, falls/trips and cuts. We distributed 4.000 prototypes in 106 countries of the first version of SSR and received expressions of interest from >150 distributors. In 5 years from market launch, we foresee an increase in workforce of 30 employees and an accumumulatedaccumulated profit of 15,2M.

Keywords: shoot remover,vine farming,reduced risk of diseases,no fuel,workers health,cost savings,high efficiency in shot removal
NeurescueTM: Computer- controlled aortic occlusion device for the treatment of cardiac arrest (CAtALySt)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2023-01-31
Duration (months): 54.0
Total project cost (EUR): 2331787.5
EU funding (EUR): 1632251.25
Participants: 1
Project status: SIGNED

With a worldwide incidence expected to increase from 9,23 million cases by 2020 to 10,89 million cases by 2030, Sudden Cardiac Arrests (SCA) episodes are today recognized as a public health problem leading to severe brain tissue damage with survival rates below 10%. Neurescue Aps (NEUR) proposes to address the SCA burden by bringing to light a game changing solution - NeurescueTM – capable of extending the critical time window necessary to bring a SCA patient back to normal heart function, and therefore holding the potential to radically improve the emergency assistance provided to SCA patients, allowing for 20- 40% of increase in the survival rate of SCA patients. Due to an algorithm-run sensor technology which enables a safe and accurate computer-controlled aortic occlusion, NeurescueTM is a portable medical device that, not only increases the blood perfusion pressure necessary for vital organs preservation (i.e. brain and heart), but also works in synergy with standard resuscitation procedures increasing their probability of success. NeurescueTM is the only device in the market that combines portability with the accuracy required for a safe medical intervention (i.e. aorta occlusion) to SCA patients both inside and outside the hospital premises. With a price-competitive technology and with an unrivalled value proposition, NEUR is in a strong position to build a profitable business. Building on the project activities, NeurescueTM the device is projected to be ready for commercial roll-out by 2021 with a predicted total aggregated revenue for the company of over €234M throughout the 5 years post- project. CAtALySt project aims to surpass the main market barriers associated with the market introduction of NeurescueTM, namely obtaining FDA clearance, gathering data for CE-marking and broad clinical demonstration for market awareness and to ensure end-user medical adoption. Pre-clinical validation will be completed with Heidelberg University Hospital in Germany on 10 in-hospital cardiac arrest patients, and with MemorialCare Heart Institure in Los Angeles, USA on 10 in-hospital cardiac arrest patients.

Keywords: sudden cardiac arrests,medical device,computer controlled aortic occlusion,vital organs,preservation
The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging (TeloRNAging)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2497500.0
EU funding (EUR): 2497500.0
Participants: 1
Project status: SIGNED

Genome instability is a hallmark of cellular and organismal aging. Cells evolved a prompt set of actions known as the DNA damage response (DDR) to preserve genome integrity. Until very recently, DDR pathways have been studied as networks of interacting proteins only. We discovered that the full activation of the DDR pathways depends also on long and short damage-induced non coding RNA synthesised from exposed DNA ends of DNA double-strand breaks (DSB). Inhibitory antisense oligonucleotides (ASO) targeting such non coding RNAs in a sequence-specific manner prevent DDR activation at individual genomic sites. Telomeres, the ends of linear chromosomes, are the best characterized genomic sites of preferential DDR activation during aging. Also telomere dysfunction, similarly to DSB, triggers the synthesis of non coding RNA and ASO against them prevent DDR activation at dysfunctional telomeres in cultured cells and in mice. We plan to determine the mechanisms that unleash ncRNA biogenesis upon telomere dysfunction and identify their mechanisms of action in DDR activation. By exploiting our unprecedented ability to inhibit DDR selectively at telomeres, we will determine the specific contribution of telomeric DDR activation to the detrimental phenotypes associated with aging-related disorders.

Keywords: telomere,dna damage response,cellular senescence,phase transition
Resolving the debate on a permanent El Niño-like state in the late Miocene: establishing equatorial Pacific conditions, driving forces and global impacts. (MIONIÑO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-23
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

A key dispute in palaeoclimate research is whether or not a permanent El Niño-like state, with warm waters spreading across the equatorial Pacific, existed during the late Miocene. Late Miocene climate was similar to the 4°C warming predicted for 2100 by the IPCC. As today’s El Niño causes global climate anomalies, a permanent El Niño-like state in the past may have had serious, global consequences, such as widespread aridity. MIONIÑO will test the existence of a late Miocene permanent El Niño-like state using geochemical microfossil records from recently recovered Western Pacific Warm Pool (WPWP) sediments and earth system modelling to assess equatorial Pacific conditions, their driving forces and global impacts. MIONIÑO is timely, only being possible since the recovery of crucial WPWP samples in late 2016. MIONIÑO is also original and novel, presenting a new template for solving complicated climate questions using a new, robust stratigraphy and an interdisciplinary approach. UCL Earth Sciences is the ideal location to pursue state-of-the-art research in palaeoceanography and stratigraphy. Combining my existing expertise with key specialist knowledge from UCL researchers will equip me with the required skills to successfully complete MIONIÑO. I can hone my research vision and gain transferable skills to help me achieve my ultimate career goal of an academic research position. MIONIÑO will advance past and future climate change research. Resolving the debate on permanent El Niño-like conditions in the late Miocene will discern whether warm El Niño events, as occurred in 2015/2016, become more frequent or evolve into a new mean state. Assessing causal links between permanent El Niño-like conditions and increased continental aridity will improve the future climate models that underpin European climate mitigation and adaptation strategies. MIONIÑO can further help us understand the true societal impact of more frequent or even permanent El Niño-like conditions.

Keywords: permanent el ni o like conditions,late miocene,benthic foraminiferal stable isotopes,planktic foraminiferal stable isotopes,modelling driving forces and impacts,western pacific warm pool
Developing Computer Vision and Artificial Intelligence for best-quality and cost-effective live sports production and distribution (OZeye)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sports play a key economic role in Europe, representing 2% of European GDP. European sports audiovisual content has significant global appeal, similar to the role that Hollywood or TV play in the USA. Only in Europe there are 50,000 leagues played in 240,000 venues, and more than 10 million fans consume sports online. Despite these numbers, fans do not actually have access to all the sports they demand: current broadcasting offering is focused on top-tier competitions (just representing 10% of total competitions) but non-premium leagues and secondary sports (e.g., female competitions), i.e. 90%, remain almost totally uncovered. This is because sports events are very expensive to produce (up to €60,000 per match, due to manpower involved in logistics, recording, editing and other time-consuming tasks). This coverage gap impacts on the complete sport ecosystem, unable to 100% exploit of their capabilities and on the low visibility of female and secondary sports. OZeye will overcome these problems. It is a software system that, by smartly exploiting latest Computer Vision, AI and robotic technologies, automatizes the production and broadcasting of sports games at the best quality, reducing production costs by 95%, enabling broadcasting of currently under-covered competitions and sports. OZeye also enhances fan-experience and expand commercial content exploitation such as stadium augmentation or integrated advertisement. OZeye is developed by OZ Sports, an Icelandic company offering general-purpose online video since 2009. We have been selected from over 600 companies for the prestigious scaling program Nordic Scalers, to help us scale up in the USA. In addition, we have been selected as one of the top 50 most innovative companies in sports for 2018 by Hype Sports Innovation, the largest global eco-system for sports innovation. We forecast accumulated profits of €28.1 million for our company in 2024 and our team to grow +120 people.

Keywords: sports,broadcasting,live sports,sports events
Tame geometry and transcendence in Hodge theory (TameHodge)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1815642.0
EU funding (EUR): 1815642.0
Participants: 1
Project status: SIGNED

Hodge theory, as developed by Deligne and Griffiths, is the main tool for analyzing the geometry and arithmetic of complex algebraic varieties, that is, solution sets of algebraic equations over the complex numbers. It occupies a central position in mathematics through its relations to differential geometry, algebraic geometry, differential equations and number theory. It is an essential fact that at heart, Hodge theory is NOT algebraic. On the other hand, some of the deepest conjectures in mathematics (the Hodge conjecture and the Grothendieck period conjecture) suggest that this transcendence is severely constrained. Recent work of myself and others suggests that tame geometry, whose idea was introduced by Grothendieck in the 1980s, is the natural setting for understanding these constraints. Tame geometry, developed by model-theorist as o-minimal geometry, has for prototype real semi-algebraic geometry, but is much richer. As a spectacular application of tame geometry, Bakker, Tsimerman and I recently reproved a famous result of Cattani-Deligne-Kaplan, often considered as the most serious evidence for the Hodge conjecture: the algebraicity of Hodge loci. I propose to lead a group at HU Berlin to explore this striking new connection between tame geometry and Hodge theory, with three axes: (I) attack the arithmetic of periods coming from the moduli space of abelian differentials; this opens a completely new perspective on this space cherished by dynamicists; (II) attack some fundamental questions for general variations of Hodge structures: fields of definition of Hodge loci (related to the conjecture that Hodge classes are absolute Hodge classes); atypical intersections, for instance for families of Calabi- Yau varieties; Ax-Schanuel conjecture for mixed period maps and for Hodge bundles; (III) attack Simpson’s « Standard conjecture » for local systems through the tame geometry of the non-abelian Hodge correspondence.

Keywords: hodge theory,periods,transcendence,o minimality