Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Strategies and technologies to achieve a European Fossil-energy-free agriculture (AgroFossilFree)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Germany,Spain,Spain,Belgium,Greece,Poland,Poland,Greece,Netherlands,Denmark,Denmark
Call: Defossilising agriculture – solutions and pathways for fossil-energy-free farming (H2020-FNR-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 1999937.5
EU funding (EUR): 1999937.5
Participants: 17
Project status: SIGNED

The aim of the project is to create a framework under which critical stakeholders will cooperate to evaluate and promote currently available fossil-energy-free strategies and technologies (FEFTS) in EU agriculture to diminish in the short term and eliminate in the long run fossil fuels use in any farming process from cradle to farm gate, while maintaining yield and quality of the end-product. Such a framework will contribute in closing the gap between the available FEFTS either commercial or from applicable research results with the everyday EU agricultural practices by promoting effective exchange of novel ideas and information between research, industry, extension and the farming community so that existing research and commercial solutions can be widely communicated, while capturing grassroots level needs and innovative ideas from the farming and related industry communities. Financing opportunities for de-fossilizing EU agriculture will be investigated and highlighted. The specific objectives are to: -consider and evaluate the current status in EU agriculture regarding energy use and assess existing needs and interests for the future farm energy profile -identify and register currently available and directly applicable FEFTS, spanning from applied research results to market solutions and investigate available financing tools for de-fossilizing activities -create an online platform containing all available FEFTS to be assessed and provide a Decision Support Toolkit to provide proposed interventions based on user inputs as well as links for those interventions financing -collaborate with all relative stakeholders in thematic groups using interactive physical and online methodologies to produce community-based ideas for FEFTS integration in agricultural systems in a regional and EU-basis -Create policy recommendations and communicate them to increase visibility and promote the proposed strategies and technologies in real agricultural activities in the near future.

Keywords: fossil energy free technologies and strategies
Selective Electrochemical Nucleophilic Fluorination (SENF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1553043.0
EU funding (EUR): 1553043.0
Participants: 1
Project status: SIGNED

The incorporation of fluorine into organic compounds is extremely important for designing molecules with specific function. Fluorine is primed for improving the pharmacokinetic properties of drugs and agrochemicals, and is crucial for the life-changing imaging technique, Positron Emission Tomography (PET). Thus, selective fluorination is an area of significant interest in organic synthesis. This research programme will develop a concept that promises to revolutionise fluorination chemistry. While nucleophilic fluoride (F-) sources are inexpensive and readily available, they have unfavourable reactivity compared to electrophilic fluorine sources (F+), which are typically expensive, wasteful and not suited to either large scale synthesis or PET. By transmuting F- into F+, we can get the best of both worlds! We will develop a concept based on umpolung (polarity reversal) to invent a number of novel synthetic methodologies or to expand useful reactions into new chemical space. The overall vision is to create new pathways to new bioactive molecules that are either more potent, have improved pharmacokinetics, or can be new radiochemical tracers. Our strategy relies on the combination of catalysis and electrochemical oxidation to perform this thermodynamically demanding task. The use of electrochemistry is essential for this strategy, because it is necessary to be able to ‘dial-in’ any oxidising potential with high control. New organo- and organometallic catalysts, heterogeneous electrocatalysts and fluoride sources will be developed as part of the studies, which will be of value to the fields of fluorination, homogeneous catalysis, synthesis and energy research. Medicinal, process and radio chemists will all benefit as their toolbox of methods will expand, thereby facilitating the discovery and manufacture of drugs and chemicals that improve the quality of human life around the globe.

Keywords: organic electrochemistry,electrocatalysis,fluorination,organometallics,heterogeneous catalysis
Smart Phone for Disease Detection from Exhaled Breath (SNIFFPHONE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Israel,Germany,Germany,Ireland,Finland,Latvia
Call: Smart System Integration (H2020-ICT-2014-1, 2014)
Start date: 2015-02-15
End date: 2019-02-14
Duration (months): 48.0
Total project cost (EUR): 5806455.0
EU funding (EUR): 5806455.0
Participants: 12
Project status: CLOSED

Screening for early detection of a disease is required to reveal groups of individuals from the general population in whom the likelihood of the disease is increased and who could benefit from further medical evaluation. The ideal screening test is high-accuracy, low-cost, non-invasive, easily repeatable, effortlessly operated by a lay-person and has minimal impact on the person’s daily activities.. In the SNIFFPHONE project, we aim to tackle these requirements by integrating heterogeneous micro- and nano-technologies into autonomous smart system that can be attached to a mobile phone and analyze disease markers from exhaled breath. In this approach, an interaction between breath sample and a miniaturized array of highly sensitive nanomaterial-based chemical sensors is recorded, stored and pre-processed by integrated miniature on-chip microfluidics and electronics, and then the relevant electrical signals are transferred wirelessly via the mobile phone’s internet to an external server. Statistical pattern recognition methods are then applied on the received data and a clinical report including the screening results is sent back to the designated receiver (e.g., specialist, family doctor) in case of positive result is revealed. SNIFFPHONE represents a new concept addressing major societal challenges in health and well-being of the general population, while taking into account constituent ethical and security aspects. The SNIFFPHONE end-product will integrate functionalities that are relevant to the health screening applications with decreased size (x30-40), decreased costs (x150), increased predictive and cognitive functions and full autonomy with energy management as well as with operation/use management. Besides the R&D and clinical units, the SNIFFPHONE project will involve four European SMEs and one big industrial company, thus establishing European competitive ecosystems for the design and commercialization of innovative miniaturized smart systems.

Keywords: nanotechnology,microfluidics,sensor,screening,breath,disease,gastric cancer,gastric disease
3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration (JointPrinting)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1999700.0
EU funding (EUR): 1999700.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide ‘off-the-shelf’, patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. The first aim of this proposal is to print a mesenchymal stem cell laden biomaterial that is both immediately load bearing and can facilitate the regeneration of articular cartilage in vivo, such that the bioprinted construct will not require in vitro maturation prior to implantation. Mechanical function will be realised by integrating an interpenetrating network hydrogel into a 3D printed polymeric scaffold, while chondro-inductivity will be enhanced by the spatially-defined incorporation of cartilage extracellular matrix components and chondrogenic growth factors into the bioprinted construct. The second aim of the proposal is to use 3D bioprinting to create a cell-free, composite construct to facilitate regeneration of the bony region of a large osteochondral defect, where vascularization will be accelerated by immobilizing spatial gradients of vascular endothelial growth factor into the implant. The third aim of the proposal is to scale-up the proposed 3D bioprinted construct to enable whole joint regeneration. Finite element modelling will be used determine the optimal structural characteristics of the scaled-up implant for it to fulfil its required mechanical function. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.

Keywords: tissue engineering,articular cartilage,mesenchymal stem cells
Imaging Mass Spectrometry of Fungal – Bacterial Interplay (FUNBIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

FUNBIT aims to enhance the discovery rate of natural products applying a multidisciplinary workflow guided by Imaging MS. Microbial genetics predict that the natural products we have discovered so far are only the tip of the iceberg, thus we may be missing the antibiotics and biopesticides of the future. In fact, many natural compounds remain invisible under standard laboratory conditions, but their biosynthesis can be triggered by re-establishing the structure of their native community in multi-microbial co-cultures. Thus, hidden natural products that enable microbes to communicate and compete with each other can be revealed. However, microbial interkingdom partnerships such as fungi-bacterial microbial interactions are still in general poorly explored. The detection of cryptic natural products from microorganisms is a major challenge because many of them are produced in small quantities, in a specific area and during a short period of time. The emerging technology of Imaging Mass Spectrometry can be the best candidate to investigate multi-partner microbial interactions in their native ecological environment, and find the natural products involved in their cross-talk. FUNBIT aims to speed up the rate of natural product discovery (especially polyketides, and lipopeptides, since many antibiotics fall into these groups) by integrating Imaging MS with High Resolution MS, spatial statistics and molecular network analysis. We will focus on fungi-bacterial partnerships involved in important agricultural infections, such as root diseases. These microorganisms are safer to handle, but the discovered antibiotics and antifungals will potentially target human pathogens. FUNBIT will be supervised by Prof. Christian Hertweck, who was awarded in 2015 with the Gottfried Wilhelm Leibniz Prize for his expertise in natural products. FUNBIT will be developed at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) in Jena (Germany).

Keywords: imaging mass spectrometry,microbial communication,natural products,fragmentation trees,fungal bacterial co cultures
Evaluations of bone strength in the evolutionary invasion of land by tetrapods (TETRAPODBONES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-22
End date: 2018-08-21
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

How tetrapods (vertebrates with digit-bearing limbs) became terrestrial is one of the most transformative yet enigmatic events in vertebrate history that set the stage for the diversification of tetrapods thereafter. Being on land imposes physical demands on the musculoskeletal system and weak bones can severely limit the capabilities of animals, yet the importance of bone strength in the evolution of terrestrial locomotion is not well understood. The proposed research integrates innovative approaches on the limbs of an early stem tetrapod, Ichthyostega, in order to: 1) quantify how well the limb bones in an early stem tetrapod could support locomotion on land, 2) compare the differences between the fore- and hindlimb bone mechanics, and 3) test the prevailing hypothesis that early stem tetrapods walked like extant salamanders. An interdisciplinary synthesis of cutting-edge techniques in engineering, 3D biomedical imaging, palaeontology, and biomechanics will be used to test the structural integrity of fossil limb bones in silico. Bone strength will be quantified with high-resolution μ-CT scans and finite element analysis, an engineering approach to estimate stresses and deformations in complex structures in response to physical demands. This novel dataset will address the ability of Ichthyostega to move on land, and what types of locomotor behaviours were not possible for an early stem tetrapod on land. Simultaneously, training and research activities in state-of-the-art engineering and 3D technology, evolutionary biomechanics, and public outreach will foster the development of the Experienced Researcher (ER) into an innovative and broadly trained researcher and science communicator. At a broader scale, tracing back the evolutionary steps to becoming terrestrial yields powerful insights into the tetrapod body plan, informing how ecological transitions influence functional innovation and how human anatomy is influenced by our ancestry from aquatic tetrapods.

Keywords: biomechanics,bone,evolution,limb,morphology,palaeontology,terrestrial locomotion,tetrapod,finite element analysis
Automatic scanner for determing lean meat distribution in pig carcasses (gmSCAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Ireland
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 1557775.0
EU funding (EUR): 1090442.5
Participants: 1
Project status: CLOSED

The slaughtering sector in the EU28 plays a key role in the meat industry. It embraces over 3,300 pig abattoirs, which process yearly 252 million pig carcasses, and generate a turnover of €73b. In a context of strong market competitiveness, and driven by the demand of meat processors, abattoirs are increasingly interested in new strategies to improve their product segmentation, which allow them to optimize the production value. The segmentation of fresh pigmeat products is mainly performed based on its lean meat content. Based on this parameter, and according to EU regulations, all carcasses are routinely sorted following the SEUROP scheme. While the SEUROP classification is useful for defining an objective payment criterion for the farmer, it is insufficient to perform a segmentation of the production and to estimate the real market value of the carcass. In particular, the SEUROP classification does not take into account the lean meat content of the primal cuts (ham, loin, belly and shoulder). Over the past decades, automatic pig carcass grading systems have risen the interest of the sector, due to its potential to improve the accuracy of meat segmentation. However, existing commercial solutions present limitations in terms of (1) limited accuracy and robustness, when dealing with different pig breeds or genetic variations; (2) complex integration in abattoirs; and (3) significant system and integration costs. We aim at addressing the market demand for a more accurate, reliable and cost-competitive solution to accurately grade and sort carcasses according to the lean meat content in the four primal cuts. The proposed technology was previously developed in a Collaborative EU Research Project, which allowed validating the technology at pilot line level (TRL7). After defining a detailed business plan, which was carried out during the Phase I project, we aim now at obtaining a qualified system (TRL9), and to obtain the SEUROP certification at two key target markets.

Keywords: automatic pig carcass classification,electromagnetic scanner
Feasibility assessment on Alarm Resolution Technology, using X-Ray Echo Methodology (ART)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Netherlands
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today’s passenger, baggage, and goods security screening works, but at great cost to public authorities and to passengers. Given the continuously evolving and shifting security threats, and passengers being increasingly dissatisfied with queues and intrusive measures, the industry agrees that today’s model is not sustainable in the long term. Goal of the overall ART initiative is the exploitation of novel Alarm Resolution Technology (ART), using novel patented X-Ray Echo Methodology, for various promising security domains. The proposed ART method of scanning, detecting and characterization is based on an all-new high-energy x-ray Rayleigh scattering technology. In the last two decades, the concept was developed based on a high energy x-ray source, using specific beam widths and collimation techniques, under specific angles/constellations for beam to sample to detector, using new semantic data-analysis methods and ‘fingerprinting’ algorithms. The Entech approach is fundamentally different from existing scanner technologies. The main paradigm in the ART project promotes a shift from just making an image, towards high-throughput measuring and characterizing of materials and fluids. Specific objectives in this ART H2020-SMEINST Phase 1 study proposal are: - Explore business cases for a variety of security domains and applications. - Evaluate the required specifications of such applications with potential customers. - Elaborate a detailed business plan. Especially on the Smart Security initiative of the International Air Transport Association policy on Liquids Aerosols & Gels (LAGs), we expect the ART platform to become (one of the) breakthrough technology enablers with the unique selling points to detect explosives, narcotics and CRBN’s solved in LAGs efficiently and cost-effectively in a growing global multi-billion market.

Keywords: detect explosives,narcotics and crbn s in liquids aerosols and gels
High Accuracy Navigation under Scintillation Conditions (NAVSCIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Viet Nam
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-02
End date: 2021-07-01
Duration (months): 36.0
Total project cost (EUR): 185288.4
EU funding (EUR): 185288.4
Participants: 2
Project status: CLOSED

The main goal of NAVSCIN is to develop an improved strategy to mitigate scintillation –a particular type of space weather perturbation– tailored for satellite-based navigation techniques, in close collaboration with users and manufacturers of these technologies. Indeed, once the scintillation effect is correctly detected and mitigated, the availability and accuracy of the five billion devices using Global Navigation Satellite Systems around the world, will dramatically improve. The project implements a set of coordinated actions among its different partners that maximize international collaboration between universities, research centres and industry, in different European and Asian countries: First, NAVSCIN will improve the understanding regarding the physical processes resulting in the formation of scintillation, and consequently to identify the drivers in the interplanetary medium, the magnetosphere and the atmosphere. Second, the impact of scintillation on space-based navigation users will be characterised: mainly Ground and Aircraft Based Augmentation Systems (SBAS, GBAS) and high-accuracy navigation techniques (Precise Point Positioning). Third, a set of NAVSCIN algorithms will be developed suitable to support, for the first time, the real-time identification, correction and/or mitigation of scintillation in GNSS receivers. Finally, NAVSCIN will work systematically with potential users to assess the functionality, reliability and efficiency of the proposed solution, paving the way to its systematic exploitation and to its sustainable operation. Overall, the European competitiveness will be potentiated throughout the project with the exploitation of the research results, ultimately giving high-level EU employment and maintaining the European status quo of high‐level‐knowledge countries.

Keywords: global navigation satellite navigation gnss,precise point positioning ppp,ionosphere modeling,scintillation,space weather,ground based augmentation systems gbas