Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Laser Research Infrastructures serving Science and Industry (Lasers4EU)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: COFUND actions
Countries involved: France,Spain,Germany,Czechia,Romania,Italy,Sweden,Netherlands,Portugal,United Kingdom,Lithuania,Poland,Switzerland,Greece,Belgium
Call: Research infrastructure services advancing frontier knowledge: co-fund pilots with pan-European RIs and/or national RIs (HORIZON-INFRA-2023-SERV-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 7180998.75
EU funding (EUR): 5000000.0
Participants: 30
Project status: SIGNED

Lasers4EU is incorporating the major laser research infrastructures, in a large number of European member states, into a comprehensive virtual distributed laser research infrastructure that is offering to a broad user community, from academia and industry, access to an exceptional portfolio of technical and scientific capabilities. This unique set of instruments together with the specific scientific expertise at the host facilities allows Lasers4EU users to carry out high-level research in an extremely wide range of high-impact topics in life sciences, materials nano-processing, etc. Laser technology has experienced remarkable advances and breakthroughs and is now a key innovation driver for highly diversified societal applications and products, thereby substantially contributing to economic growth and to solving challenges in the areas of health, environment and energy. Through its strategic approach, Lasers4EU aims to strengthen Europe’s leading position and competitiveness. It facilitates long-term coordination of the laser research activities within the European Research Area and provides concerted and efficient services to scientific, industrial and medical researchers. The main objectives of Lasers4EU are to: • provide coordinated access to high-quality services based on a coherent and comprehensive consortium of 27 leading European laser installations offering to users from academia as well as from industry cutting-edge performances at the forefront of the laser technologies, • structure the European landscape of laser Research Infrastructure through enhanced access, extended geographical coverage, novel science diplomacy activities, improved synergies with other European networks and projects, • increase European human resources in the field of laser science by implementing training activities towards researchers from new domains of science and technology and from geographical regions where laser communities are still less developed.

Keywords: natural sciences,lasers,physical sciences,optical technologies,photonics,materials research,biomedical optics,bio imaging,high field science,laser spectroscopy,laser applications
CogiGame GenAI: Expanding Rehabilitation Horizons (CogiGame GenAI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

CogiGame GenAI represents a groundbreaking advancement in the field of stroke rehabilitation, utilizing a unique blend of technology and human interaction to address a wide range of physical rehabilitation needs. Developed in collaboration with prominent figures such as Dr. Robert Simister, and driven by a collaborative effort involving stroke survivors and physiotherapists, this innovative solution leverages EEG-based technology to enhance neural plasticity and motor function recovery. The platform integrates an immersive, gamified user experience with remote monitoring capabilities, providing a versatile and engaging approach to therapy. The key to CogiGame GenAI's success lies in its neuroscience-informed EEG decoding technology. Empowered by end-to-end deep learning models and trained on proprietary multimodal EEG data, the platform promises a transformative experience in stroke rehabilitation. However, the current limitation in hardcoded movement type variability and EEG data accuracy is being addressed through the development of multimodal EEG foundation models. These AI models aim to enable fast scaling and adaptation to diverse movements and EEG headsets, thereby widening the application scope in stroke rehabilitation. Cogitat's BCI solution, currently at TRL 5/6, is poised for significant advancement with the support of the EIC grant, aiming to reach TRL 8. This progression is not just a technological leap but also a strategic move to expand into the EU market and beyond, setting the stage for global outreach. The project's ambition extends to broader applications such as Neurodegenerative Diseases, TBI Recovery, and Elderly Care, underscoring its potential impact in the healthcare sector. With its non-invasive, AI-driven approach, high accuracy, adaptability, and compatibility with any EEG headset, CogiGame GenAI stands out as a more user-friendly and scalable solution compared to existing offerings.

Keywords: the core of the project centres on the development of multimodal eeg foundation models,which are pivotal in enhancing cogigame genai s ability to accurately interpret a wide range of brainwave signal
Two-dimensional high entropy alloys and ceramics (HighEntropy2D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1995465.0
EU funding (EUR): 1995465.0
Participants: 1
Project status: SIGNED

“Entropy engineering” recently had exceptional impact on bulk materials science by invention of bul“Entropy engineering” recently had exceptional impact on bulk materials science by invention of bulk high entropy alloys and ceramics. The underlying idea is that by equiatomically adding ≥5 principal elements to alloys/compounds, the much increased configurational entropy stabilizes otherwise non-accessible single “high entropy” phases with an unique random elemental occupancy on a crystalline lattice and hence novel functional properties. Likewise, reducing dimensionality in “two-dimensional” (2D) materials recently had exceptional impact on materials science due to the 2D materials’ unique functional properties. Despite these exciting individual prospects of “entropy engineering” and “2D materials”, combination of these two concepts to synergetically create novel 2D high entropy materials (2D HEMs) as a novel materials class with novel functional properties with possible applications in electronics and catalysis remains lacking. In “HighEntropy2d” we will fabricate unprecedented 2D HEMs (2D high entropy alloys, oxides and sulfides) using for the first time scalable vapour deposition and a 2D template/2D confinement approach for both 2D film and 2D nanoflake form, asses their novel properties and perform first tests of their applicability for electronic devices and catalysis. Reducing HEM dimensionality to 2D will also create a unique opportunity to for the first time study in situ and at the atomic scale currently unknown fundamental diffusion, crystallisation, phase transition and separation mechanisms in HEMs (using a globally unique (scanning) transmission electron microscopy ((S)TEM) setup), to obtain fundamental insights relevant to HEMs even beyond the here newly introduced 2D HEMs. The proven track record of principal applicant Bernhard C. Bayer in 2D materials synthesis and atomic scale in situ (S)TEM is an ideal basis for this ambitious research programme.

Keywords: entropy engineering,2d materials,high entropy alloys,graphene,aberration corrected scanning transmission electron microscopy
Revolutionising waste reduction from upcycled resources: Enabling waste-to-value for agro-food industry and natural cosmetics (PURE-WAY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Serbia,Romania,France,Argentina,Netherlands,Greece,Germany,United States
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 1345542.86
EU funding (EUR): 1122240.0
Participants: 10
Project status: SIGNED

Globally, one-third of food production is wasted, leading to significant loss of resources and greenhouse gas emissions. Creating new, sustainable solutions to the problem of food waste is a pivotal goal of the EU. PURE-WAY aims to tackle this issue by fostering crosssectoral and multi-actor collaboration to devise new circular zero-waste solutions for fruit and vegetable waste. Together, we will develop cutting-edge biotechnologies: industrially applicable green solvents for extracting high added-value bioactive compounds; computational modeling-driven smart fermentation; and a next-generation eco-friendly composting system using specifically engineered synthetic microbial consortia. Through these innovative approaches, PURE-WAY will transform fruit and vegetable waste into functional foods with health benefits (2 functional beverages and natural cosmetics product), bio-based chemicals for eco-friendly solvents, and biofertilizers. The resulting technological advancements will help address key food system challenges, natural cosmetics, providing safe, nutritious, healthy and affordable food, and supporting sustainable agriculture practices. The project integrates 11 partners from 8 countries, including 6 from Europe, 1 from South America and 1 from North America, merging 6 academic and 5 non-academic partners to facilitate 70 secondments (224 months), 13 between academic to academic (50 months) and 57 secondments (174 months) between academic to non-academic representatives. By fostering knowledge and markedly cross-disciplinary skill exchanges, PURE-WAY will substantially enhance research and innovation capacities through reaching well-defined objectives. This holistic approach will decisively contribute to creating a sustainable, circular food economy, aligning with EU policies and global sustainability goals.

Keywords: fruit and vegetable waste,analytical and food chemistry,circular economy,chemical engineering,biodegradation,innovation managment,computational biology
Cell decision capture and control via joint Raman live and omics profiling (MOVIOLA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499329.0
EU funding (EUR): 1499329.0
Participants: 1
Project status: SIGNED

The developing nervous system generates an extraordinary diversity of cell types through a series of critical fate decisions made by neural progenitors. Despite recent progress in cataloging the heterogeneity of brain cells, we lack an understanding of the factors orchestrating their fine specification, especially in humans. As a result, many decision processes have uncharacterized determinants and are accounted for as stochastic, leaving us without control over them. This knowledge gap stems from the absence of a systematic approach to capture dynamic moments of cell decision-making and discover the factors controlling them. I hypothesize that most fate decisions in the human developing nervous system are not stochastic and, instead, depend on many fine-grained, dynamic mechanisms of cell decision-making. However, only a limited number have been characterized, too few to explain the thousands of cell types in the human brain. To explore this hypothesis, I propose a novel experimental paradigm to elucidate the molecular determinants governing cell decisions. The approach combines live-cell Raman spectrometry imaging, omics profiling, and inducible degrons. I designed it to operate on cell decisions like a film-editing machine, a Moviola: from an outcome, it learns how to “rewind” to a cell’s decision, “halts” the cell and profiles it for decision determinants, and “edits” it to steer it away from the original outcome. By applying this approach, we expect to find factors influencing fate decisions in human neural specification and reveal a more deterministic control of neural cell fates, illuminating how the vast cellular diversity originates from decision-making events. The insights gained will offer ways to improve in vitro models and cell therapies, with potential implications in the attenuation of neural disorders. This groundbreaking paradigm revolutionizes the study of cell decision-making, with far-reaching implications across diverse fields of biology.
Sex differences in BNST prepronociceptin-expressing neurons in modulating chronic stress-induced depressive-like behaviour in mice (PnocMDDSex)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-09-30
Duration (months): 37.0
Total project cost (EUR): 285140.64
EU funding (EUR): 285140.64
Participants: 3
Project status: SIGNED

Major Depressive Disorder (MDD) is a highly prevalent and disabling condition experienced by ~6% of the population worldwide. Interestingly, women are twice as likely as men to suffer from MDD, and the specific mechanisms contributing to such difference are only starting to be elucidated. Chronic mild stress has been shown to reproduce in rodents some of the main traits of MDD, such as anhedonia or anxiety-like behaviour. Chronic stress has been shown to interfere with prepronociceptin (Pnoc) expression in the anterior BNST (amBNST) in rodents. Interestingly, it has been established a functional antagonistic role of Pnoc neurons over corticotropin-releasing hormone (CRH)-expressing neurons, which mediate the stress response in mammals. Moreover, amBNSTPnoc neurons have been shown to support rapid arousal responses toward motivationally salient stimuli in mice. Preliminary data has demonstrated sex differences in amBNSTPnoc distribution across compartments, indicating possible sex-dependent effects of stress on amBNSTPnoc function. We aim to explore sex differences in amBNSTPnoc neurons in rapid arousal responses upon sucrose presentation and its relationship with chronic stress-driven anhedonia. To that end, rapid arousal responses in male and female mice will be studied after chronic stress in mice, and related to anhedonic-like behaviour, and Pnoc and CRH expression in compartments of the BNST. To further understand the effects of chronic stress in Pnoc neurons, calcium transients using 2-photon calcium imaging in amBNSTPnoc neurons will be studied before and after chronic stress. Chemogenetic activation of amBNSTPnoc after stress will be used to functionally test that low Pnoc expression drives hypoarousal states related to anhedonic behavior. The proposal aims to elucidate sex differences in the pathophysiology of chronic stress-driven depressive-like behaviour and provide new perspectives and ideas on the higher prevalence and treatment resistance in females.

Keywords: major depressive disorder chronic stress sex differences prepronociceptin arousal
Dwelling with Crisis: Home at Spaces of Chronic Violence (HOMCRI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1923180.0
EU funding (EUR): 1923180.0
Participants: 1
Project status: SIGNED

This project elaborates ways of making home among those dwelling in societies facing protracted crises. It traverses through various landscapes to look at ways in which people make home in spaces that are familiar, yet repelling, incapacitating and altogether negating in nature. Such landscapes, notably in Lebanon, the West Bank and Gaza, reflect various forms of crises engendered around economic collapse, infrastructural shortage, prolonged conflict-situation and/or continuation of war by other means. These crises force us to pose a key question on what it means to stay, and make a home, in spaces that constantly expose life to disruptions, incapacitations, and material negations. How does one dwell in crisis? The project responds to this research challenge via ground-breaking research that goes beyond the state-of-art on three fronts. Firstly, it generates vast empirical knowledge on what it takes to dwell in crisis and conflict areas, and with the political conditions they establish, by focusing on spaces that violently separate, distance, and amputate people from their familiar everyday spaces through constant affective disruptions, material deprivations, and conditions of incapacitation. Secondly, it does so by developing negativity as a novel methodological tool for approaching dwelling as a tension between ‘home-making’ and ‘spaces of exposure’. Thirdly, it offers a novel conceptual elaboration of negativity as a worldly condition, which challenges the paradigmatic notions of materiality, affect and dwelling in current posthuman thought. Designed for high-gain outputs, the project takes a high risk in offering ground-breaking research that aims to fundamentally rethink the negative foundations of human-world relationship by focusing on ways in which negative material and affective bindings align with incapacitating political conditions in prolonged crisis and conflict situations.

Keywords: dwelling,political ontology,affect,materiality,middle east
Systems-level investigation of the immune-reproductive crosstalk in humans (fertiliMMUNE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2027-01-01
End date: 2031-12-31
Duration (months): 60.0
Total project cost (EUR): 1499861.0
EU funding (EUR): 1499861.0
Participants: 1
Project status: SIGNED

Infertility affects 1 in 6 adults worldwide. Current infertility therapies overlook its underlying causes, resulting in pregnancy success rates as low as 30%. Together with the emotional, financial, and societal toll of infertility, this low efficacy underscores the urgent need for more precise interventions. fertiliMMUNE aims to uncover mechanisms of human immune-reproductive crosstalk and define novel targets for fertility treatment. Reproduction and immunity are deeply intertwined, highlighting the immune system as a promising target for fertility treatment. A successful pregnancy requires coordinated immunological adaptations that already start at conception. Yet major gaps still exist in understanding i) the mechanisms of interactions between the immune and the reproductive systems, and ii) the impact of these on pregnancy outcomes. Systems immunology combines multi-omics methods and innovative computational approaches to understand the complexity of the immune system and its components. My expertise in systems immunology (Consiglio et al, 2020 Cell) and reproductive sex hormone modulation of human immunity (Lakshmikanth*, Consiglio* et al, 2024 Nature) provides a unique perspective to dissect immune-reproductive networks that are critical for human immune function and reproductive success. fertiliMMUNE will elucidate the immune-reproductive crosstalk at unprecedented detail in humans. Work package 1 (WP1) will employ systems-level longitudinal immune profiling during in vitro fertilization (IVF) to dissect how sex hormones regulate the immune system in vivo. WP2 will identify immune signatures at baseline and in response to IVF treatment that predict IVF success. WP3 will comprehensively characterize the direct regulatory mechanisms of sex hormones in immune cells of healthy women and men in vitro. fertiliMMUNE will provide key insights into immune-reproductive co-regulation and pave the way for personalized fertility treatments that improve IVF outcomes.

Keywords: sex differences in immunity,reproductive immunology,immune reproductive crosstalk,systems immunology,human immunology