Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High performance algorithms for high precision GPS and cloud solutions for super resolution microscopy (NanoMAPs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The 2014 Nobel prize in Chemistry was awarded for the development of super resolution fluorescence microscopy, also known as nanoscopy. It is an innovative technique that has made a breakthrough in imaging and biology, resulting in novel discoveries in the fields of virology, immunology, neuroscience and oncology. Super resolution is on its way to becoming the new gold standard in light microscopy. However, nanoscopes (super resolution microscopes) are still largely under-used. Their high cost, a time-consuming sample preparation process and a high degree of required technical expertise are the key factors limiting the growth of this emergent market. Abbelight is revolutionising the nanoscopy market by turning an ordinary light microscope into an automated, easy-to use, high performance 3D nanoscope and cloud-based software for data analysis, storage and sharing. New algorithms will be developed for this precise and automated sample imaging procedure. The SME Instrument project will allow Abbelight to develop revolutionary solution called “NanoMAPs”. It will disrupt the nanoscope market by addressing a wide variety of needs of the nanoscopy sector. It will help initiate new international business opportunities. It will also bring in new types of clients, in particular industrial companies that require automated lab systems such as pharmaceutical companies, Contract Research Organisations (CROs) and large imaging platforms. To accomplish their goals, Abbelight will complete a feasibility study to (i) develop a new numerically controlled and automated sample imaging procedure, as well as a new cloud SaaS platform (ii) secure intellectual property rights and (iii) validate the economic viability of NanoMAPs. Abbelight plans to lead the both European and global nanoscopy markets with an estimated turnover of about € 22 million and the creation of 27 new European jobs by 2022.

Keywords: super resolution microscopy,nanoscopy,algorithms,automation,cloud,saas,machine learning,big data
Innovative processing plant for optimal production of Decolourised Hydrolysed Protein (DHP). A secure, cost-effective and eco-friendly blood by-product solution. (HYDROBLOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-05-01
End date: 2019-08-31
Duration (months): 28.0
Total project cost (EUR): 2854416.25
EU funding (EUR): 1998091.38
Participants: 1
Project status: CLOSED

Blood is a common by-product of the meat industry, which is obtained in large volumes especially in industrial slaughterhouses. Approximately 1,452 million pigs were processed worldwide for their meat in 2013. The annual available blood supply exceeds 4.35 million tonnes worldwide. Taking into account a typical protein content around 18%, 783k tonnes of protein could be produced worldwide. In spite of the significance of this sum, an important part of the collected blood is not considered but a waste. The reason lies in the lack of suitable facilities in the slaughterhouses to properly collect and handle blood. Hence, a high percentage of the abovementioned amount of protein becomes a waste, which requires expensive decontamination treatments and large amounts of water. On the other hand, the collection of blood in most of the slaughterhouses where it is considered a by-product is carried out together with other by-products, treated un-specifically in large digesters. This process avoids part of the costs of elimination because it excludes the decontamination treatments, but the obtained end-product does not have a remarkable added value and the possibility of valorisation remains unexploited. From TALLERES AZUARA we have identified the business opportunity behind this market weaknesses, and we have developed the HYDROBLOOD processing plant to solve all of them, which is a secure, cost-effective and eco-friendly system for blood collection and processing. With current technologies available into the market, only around 35% of the protein contained in blood can be recovered as an added-value by-product. With our innovative HYDROBLOOD processing plant, the 100% of protein content can be recovered from animal’s blood, and converted into a high added-value product: The Decolourised Hydrolysed Protein (DHP). This will make a big impact within the European Protein Market, valued at 2,547,000 Mt in 2013, and estimated to increase by more than 40% the next 10 years.

Keywords: animal by products,animal blood,animal protein,hydrolysed protein,feed,feed additives,slaughterhouse,rendering plant,waste treatment,processing plant,blood rendering,blood processing
Targeting mitochondrial defects and oxidative stress in Pompe Disease: from pathogenesis to therapy (MITOPOMPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The central role of ATP production by oxidative-phosphorylation, together with calcium buffering and apoptosis, makes mitochondria an organelle interacting with many processes within the cell. Neuronal and muscular tissues require high amounts of ATP to perform their everyday function, therefore are heavily dependent on mitochondrial function. Neuromuscular synapses are of particular importance since synaptic transmission is a highly regulated process which requires active and functionally competent mitochondria. Accordingly, mitochondrial involvement is becoming increasingly evident in is Lysosomal Storage Disorders (LSDs) along with neurological pathology. Over the past several years Dr. Mingozzi’s group has built extensive expertise in Pompe Disease (PD), an LSD which is caused by mutations in the enzyme acid α-glucosidase (GAA). Muscle weakness, cardiomyopathy, respiratory failure, central nervous system and more specifically motor-neuron defects are observed depending on the severity of the disease. Little is known about the role of mitochondria in the pathophysiology of PD and interventions aimed at addressing mitochondrial defects in PD is currently missing. The aim of this proposal is to characterize the mitochondrial dysfunction in the Gaa KO mouse model of PD. This to assess potential rescue of such phenotypes by AAV-based GAA gene therapy complemented with therapeutic interventions targeted to treat and boost mitochondrial function by fighting against oxidative stress. Two mitochondrial treatment approaches; (i) pharmaceutical antioxidants, e.g. mitoQ or mtGSH and (ii) AAV based approaches; AAV-Nrf2 and AAV-mitoCatalase will be tested. Combined therapies with the AAV-GAA treatment will aim to reach full rescue of the muscle and brain pathology and functional reversal of mitochondrial defects. Transcriptomic changes will also be analyzed by RNA sequencing to investigate cellular signaling changes which will potentially point to novel therapeutic avenues.

Keywords: gene therapy,pompe disease,rare disease,glycogenosis,mitochondria,oxidative stress
Micro-scale optofludics control based on thermoplasmonic effect of nanoparticle arrays (MOFCTP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Optofluidic control is emerging as a promising tool in wide applications like pharmaceutics, chemistry, energy, and biology, due to the development of micro-fluidic chip. The control unit usually requires complex optical set-ups or special materials for working fluid or micro-channel. The aim of the present project is to develop a light controlled microvalve technique that can be utilized to manipulate fluid flow in micro-channels and potentially promote the development of new generation of light driven micropump or micromotor. Numerical model and experimental setup will be established to investigate nanoscale photothermal conversion and temperature manipulation involved in the plasmon-assisted optofluidics. Duo to wide applications of microfluidic devices, this unique project will not only be helpful for European biomedicine industry, including R&D of new drugs, but will also promote fundamental research level in related areas, such as microfluidic control and thermoplasmonics. The project is carefully designed to match the fellow's expertise in thermoplasmonics and the expertise of the host institute in micro-flow and heat & mass transfer. The overall aim of the project is to develop a light controlled microvalve technique that can be utilized to manipulate fluid flow in micro-channels. Meanwhile, the research fellow will contribute his expertise on thermoplasmonics and photothermal conversion, and will provide important training to EU researchers, industrial contacts and undergraduates by: hosting a series of seminars, giving a special lecture on thermoplasmonics for undergraduate students, and participating in outreach activities of the university. The researcher has 5 years’ experience on experimental and numerical studies for nanoscale thermoplasmonics. Combining the host’s supervision on micro-flow and heat and mass transfer, the fellowship will provide him with perfect opportunity to develop the proposed project on optofluidic control.

Keywords: optofludics,thermoplasmonic,micro fluid flow,plasmonic nanoparticles microvalve,lab on a chip,temperature manipulation,photothermal conversion
Fatigue Damage and Healing of Bituminous Materials: from Microscopic Mechanism towards Lifetime Extension (FHBMicro)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

FHBMicro aims to train a talented young researcher through an interdisciplinary research focused on investigating the microscopic mechanisms of fatigue damage and healing of bituminous materials (BMs) to fundamentally extend the materials’ service life. The main deliverables resulting from the FHBMicro include a better understanding of the microscopic mechanisms of the BMs’ fatigue damage and healing, a trans-scale performance prediction framework and evaluation protocol of the fatigue and healing of the BMs, and an implementation of anti-fatigue and self-healing BMs and technologies in durable and sustainable road construction. Through the project, the Fellow will receive intensive scientific knowledge training in multidisciplinary field of chemistry (TUD), material science (TUD), computational modelling (TUD and RWTH), experimental characterisation (UoN) and industrial applications (Nynas and Duro Vermeer). The Fellow will also receive inter-sectoral complementary skills training in project management, intellectual property protection, teaching and supervision, and networking. The benefits brought by FHBMicro are represented by strengthening the EU scientific excellence and industry leadership in the innovation, evaluation and engineering application of the durable and sustainable road materials. The implementation of anti-fatigue and self-healing BMs and technologies in road infrastructures will extend the road service life and ultimately save natural resources like petroleum bitumen and reduce greenhouse gas emissions. Uniquely, the project will enable the Fellow to obtain interdisciplinary knowledge and inter-sectoral complementary skills by building a new and exciting research field, which will pave a solid foundation for the Fellow towards his career of being an independent leading researcher in the area of durable and sustainable infrastructure materials in a top European university, with a Europe-linked collaborative network.

Keywords: road infrastructures,construction materials,bitumen,asphalt,fatigue,healing,trans scale modelling
Virtual Multimodal Museum (ViMM)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Coordination and support actions
Countries involved: Spain,Germany,Austria,Cyprus,Slovenia,Switzerland,Greece,Netherlands
Call: Virtual museums and social platform on European digital heritage, memory, identity and cultural interaction. (H2020-SC6-CULT-COOP-2016, 2016)
Start date: 2016-10-01
End date: 2019-03-31
Duration (months): 30.0
Total project cost (EUR): 1351800.0
EU funding (EUR): 1170550.0
Participants: 8
Project status: CLOSED

Virtual Multimodal Museum (ViMM) proposes a major, high-impact CSA across the field of Virtual Museums (VM), within the overall context of European policy and practice on Virtual Cultural Heritage (VCH). A highly expert seven (7) partner consortium will leverage the support of a unique and powerful Advisory Group, consisting of many of the Europe and the world’s leading public and private sector organisations in the field, to define and support high quality policies, strategic and day-to day decision making, the utilisation of breakthrough technological developments such as VR/AR and to nurture an evidence-based view of growth and development impacted by VM, supported by a set of case studies in culturally-rich regions of South Europe affected by economic recession. Its work will be founded on building a consensual framework directly involving Europe’s leading VM decision-makers and practitioners in defining and resolving existing issues spread across 7 interlinked Thematic Areas (‘the 7 Ds’): Definitions – Directions – Documentation – Dimensions – Demand- Discovery - Decisions and will result in wide-reaching stakeholder participation and very high visibility. The latter will be achieved through organisation of key events at policy and practitioner/stakeholder levels, extensive use of the media, and by the introduction of a highly interactive and wide-reaching communication platform, deploying social media and novel approaches to enable focused debate by all interested parties, supported by access to representations of excellence and a decision-support tool for stakeholders. An initially broad and open approach will be refined through a process of definition, consolidation and resolution activities to arrive at a clear Manifesto and Roadmap for Action on VM, validated at a final ViMM international conference. Measurable impacts will be achieved on the role and capability of VCH – and VM in particular – to meet their enormous potential in society and the economy.

Keywords: virtual museum,e museum
Resilient steel frame against fire and seismic hazards (ResFrameFireSeismic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Conventional seismic-resistant structures are designed to experience significant damage under moderate-to strong earthquakes and this results in socio-economic losses such as injuries, high repair costs and disruption of the building use or occupation. To address this issue, researchers have developed modern seismic-resilient frames that can avoid inelastic deformations (i.e. damage) in structural members. Fire is another type of loading, which can cause significant damage and collapse. Moreover, fire after strong earthquakes is also a highly probable catastrophic event as it has been seen after recent earthquakes (e.g. Indonesia 2009, Chile 2010). Despite the fact that the risk of fires is high after strong earthquakes, seismic resilient structural systems have not yet been studied against fire and fire after earthquake loading. This project will assess the behaviour of modern seismic-resilient self-centering post-tensioned steel frames against fire loading and will propose modifications of their structural details so that, apart from seismic resilience, fire robustness can be also achieved. The project aims to develop, for the first time, an innovative steel frame characterized by the unique combination of minimal damage seismic behaviour and robustness against fire and post-earthquake fire loading.

Keywords: earthquake,fire,resilience,steel frame,structural engineering
Light-engaged Accommodating IOL (Light AIOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Presbyopia, the age-related loss of the ability of the eye to focus near and far objects, affects 1.2 billion people in the world. While there are a number of corrections for presbyopia available (near and progressive spectacles, monovision or multifocal lenses) none of these restore the dynamic focusing capability of the young crystalline lens. Replacing of the rigid crystalline lens in the aged eye by a shape-changing artificial lens able to respond an accommodative demand, therefore restoring accommodation in the aging eye, will undoubtedly increase the quality of vision, quality of life and productivity of millions of presbyopes worldwide. Presbyopia ERC Advanced Grant Presbyopia investigates basic mechanisms of the crystalline lens accommodation, to propose nature-inspired IOL designs to correct presbyopia. Imaging technologies developed during the project have allowed imaging-based quantification of the crystalline lens structure and its change with accommodation, aging and treatment. Knowledge gathered using these technologies, and developments combining optics, biomechanics, biomaterials and photo-chemistry have allowed a new concept for an accommodating IOL, of which the first prototypes have been manufactured and tested, therefore materializing the ultimate goal of the Presbyopia ERC AdG grant. This research has allowed to propose, develop and test a novel surface-change accommodating IOL, and a disruptive photo-activated method to transmit the forces from the eye muscle into the lens, both protected by patents filed during the ERC AdG. The Light-AIOL ERC-Proof of Concept aims at evaluating the marketability of the developed AIOL platform and at reaching a product commercialization plan to be presented to industrial and financial investors with the ultimate goal of bringing to market this technology, and move to a phase closer to deployment in patients. This should bring surgical corrections of presbyopia into a new paradigm.

Keywords: presbyopia,accommodation restoration,intraocular lens,cataract surgery,photoactivation,light,vision
Fragility and Geopolitics in the Middle East and North Africa (FLAME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-11-01
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

State fragility at the EU’s immediate Southern doorstep is a key challenge for European foreign policy in the coming years. War and fragility in the Middle East, exacerbated by geopolitical competitions, allowed the proliferation of violent non-state actors such as the Islamic State and triggered the greatest refugee crisis since World War 2. Reflecting key priorities of the Horizon 2020 work programme (Europe in a changing world-inclusive, innovative and reflective societies and Secure societies-protecting freedom and security of Europe and its citizens), FLAME will: 1) map the political, security and socio-economic drivers of fragility across the Middle East and North Africa; 2) assess how these are reinforced by state and non-state actors’ pursuit of geopolitical interest; and 3) explore opportunities for EU and US to jointly ease these dynamics. The fellow, currently heading the Middle East department at a renowned Madrid-based think tank, builds on a decade of experience in both academic and policy research on Euro-Mediterranean relations, and has frequently provided policy advice to EU institutions.The host, the Brussels branch of one of the most renowned institutions on transatlantic cooperation, links up EU and US policy debates on Middle Eastern security affairs. Its offices in Washington, Berlin, Paris, Warsaw and Ankara provide a privileged institutional frame for the triangular research proposed. The partnership will produce ample mutual benefit and skills transfer as it will expand the fellow’s global network; broaden her expertise in security, US policy and non-state actors; and multiply her career prospects by exposing her work to a transatlantic high-level audience. The host will fill a gap in its expertise portfolio and strengthen its academic profile and European presence on Middle Eastern affairs. Using the host's unique global reach, the project will feed research results into the ongoing process of revision of the EU’s foreign policy.

Keywords: geopolitics,fragility,conflict,european union,mediterranean,middle east,north africa,united states