Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Roman Coin Circulation in Ancient Armenia (RoCCAA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-07-02
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

This project intends to analyze Roman monetary circulation in the kingdom of Armenia from the Ist century BCE to the fall of the kingdom in 428 CE. Because of Armenia’s strategic location, several attempts were made to gain control of it, particularly by the Roman and Parthian/Sassanid empires, whose coinage found its way into Armenia. This project will study the evolution, the purpose and the impact of Roman coinage on the Armenian Kingdom. This project breaks away from Armenian studies, hitherto based solely on Greek and Roman textual sources, at a geographical and chronological level, as it focusses on concrete data from the Armenian Kingdom itself. Using an interdisciplinary approach, the project will improve our general understanding of Armenian and Roman history, but also clarify the regional history in the light of specific Armenian events, thanks to a new approach in the field of Armenian studies. Likewise, it will add new evidence to our knowledge of Roman coinage in the East. The preliminary data – a comprehensive coin corpus – has already been collected and catalogued. To successfully complete this project, I will join the numismatic team at Oxford University. This host institution is no doubt the ideal choice. Its eminent numismatists have worked on the provincial circulation of Roman imperial coinage, it houses both Armenian and Numismatics departments, and the Ashmolean Museum’s numismatic holdings at Oxford are of prime importance. This project requires good prior knowledge of the historical situation in Armenia as well as of the history and ambitions of the Roman, Parthian and Sassanid Empires. Numismatics in Armenia also needs to be grasped in all its diversity. For these reasons, it is necessary to master languages from the region, to be aware of past and current research and the many factors bearing on Armenian studies, such as Soviet ideology or nationalist issues. All these conditions are met here allowing this ground-breaking project to thrive.

Keywords: ancient armenia,numismatics,roman empire,parthian empire,imperial coinage,provincial,coinage,countermark
Novel heart regeneration strategies (aNtHESIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2016-01-01
End date: 2017-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Heart disease and particularly myocardial infarction, i.e. heart attack, is the leading cause of death in the Western world today. The diminished regenerative potential of the heart begins shortly after birth, when most CardioMyocytes (CMs) cease to proliferate and make a transition from hyperplastic to hypertrophic growth. The Tzahor lab has been intensively exploring novel molecules, compounds as well as the molecular mechanisms that facilitate CM cell division in the adult heart of mammals as a strategy for eliciting heart regeneration. These efforts, had led to the identification of novel compounds which significantly increased the proliferation of adult CMs. Drawing upon these findings, the aim of the aNtHESIS project is two-fold. First, to (i) validate the pre-clinical application of our two novel compounds by conducting comprehensive in-vitro and in-vivo tests in mice as well as by carrying out experiments using human CMs. The second aim is (ii) to establish the business feasibility of our cardiac regenerative therapy concept by taking the necessary steps towards the commercialization of our novel compounds, focusing on the creation of strategic alliances with key private sector companies.

Keywords: cardiac regeneration,cardiomyocytes,myocardial infarction,dedifferentiation,novel compounds,commercialization
Genomics Data Analysis Pipelines with Interactive Visualizations (GDAPIV)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Slovenia
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The GDAPIV project will deliver a next generation of genomics analysis and visualization web platform GenX that will enable bioinformatics experts (IT experts supporting life scientists) to rapidly construct diverse visual interactive web applications for researchers working in the life sciences and biomedical fields (life scientists). GenX will enable the researchers or biomedical experts to proactively control the bioinformatics data analysis and exploration steps when validating research hypotheses. It will eliminate the need for continuous involvement of bioinformatics expert in every step of data analysis procedures, thus greatly facilitating the speed and simplicity of experimental or diagnostics processes. Even more importantly, GenX project will provide the researcher with instant insight into the genome sequence data and related downstream analyses, allowing to interactively modify and test the research hypothesis and assess them in real time, as they arise. This will significantly save time and resources, and it will disrupt the approach to the life science research and related services. With the GDAPIV project, we strive towards “riding the wave” of the genomics revolution – exploiting the Next-Generation Sequencing opportunity and significant expansion of sequencing machine owners (biotech, clinics, pharmaceuticals, basic research, commercial sequencing facilities) – all of these are potential customers, especially considering the pitfalls of existent solutions available to the commercial sector. The purpose of GDAPIV project is: - to create and test GenX prototype and - to explore business models that exploit the project’s commercial potential to the fullest.

Keywords: informatics,bioinformatics,biotechnology
Commercialization of a full carbon wheel manufactured with an automated high-volume process for the automotive market (CARIM)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Italy,Germany,Italy,Austria
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-01-01
End date: 2018-04-30
Duration (months): 28.0
Total project cost (EUR): 2429466.0
EU funding (EUR): 1930033.88
Participants: 5
Project status: CLOSED

The aim of CARIM is the final development, homologation and commercialization of a full carbon automotive wheel manufactured in an automated, high-volume production process. Within the 2-year project the TRL level, currently 6+, will be raised to 8+ or 9. Developments in automated CFRP production technology will generate a wheel that is 30-50% lighter than state-of-the-art Al-wheels, with the extra advantage of excellent mechanical performance. The manufacture of the wheels in an automated preforming and HP-RTM process will ensure short cycle times (max. 10 min/component) and lower costs (1634€/wheel in first year of production and 1164€ in 2020) that will enable scale-up to series production and make the CARIM wheels competitive against current casted and forged Al-wheels and other emerging plastic wheel concepts. A testing and validation phase for the demonstrators covers a comprehensive product homologation to meet TUV regulations and the requirements of OEMs and material suppliers. The market entry of the product is clearly detailed in the proposal’s business plan which predicts a commercially-available product within one year after the project ends. The strategy for implementing the carbon wheel on the market is a top-down approach starting with a low production volume for high class cars and a steady rise in carbon wheel production. The five-year goal is a production capability - only at RiBa - of 52.000 wheels per year by 2020. The technology also has the potential for transfer into higher-volume car segments in luxury/medium-class vehicles, as well as to helicopter and aviation applications. The industry-driven consortium is supported by strong partners integrated in an Industrial Exploitation Board (Bentley, Huntsman) providing technical and economic consulting and know-how. The project results will be systematically disseminated and exploited to maximize visibility, industrial take-up and the transfer of the developments to new markets.

Keywords: automotive lightweight wheel,plastic wheel,full carbon wheel,automated manufacturing of cfrp,high volume cfrp production,preforming,hp rtm process,assembly of cfrp substructures
Artificial cell-cell interactions for light switchable cell organization and signaling (ARTIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-07-01
End date: 2024-06-30
Duration (months): 72.0
Total project cost (EUR): 1937000.0
EU funding (EUR): 1683867.5
Participants: 2
Project status: SIGNED

The bottom-up assembly of tissue from cellular building blocks constitutes a promising, yet highly challenging approach to engineer complex tissues. The challenge lies in controlling cell-cell interactions, which determine how cells organize with respect to each other, how they work together and consequently whether such a multicellular architecture will be functional. The limited spatial and temporal control over cell-cell interactions current biological and chemical approaches provide severely restricts bottom-up tissue engineering. Here, I propose a new way to control cell-cell interactions. I aim to regulate cell-cell interactions with visible light using proteins that reversibly homo- or heterodimerize under blue or red light. These photoswitchable cell-cell interactions provide sustainable, non-invasive, dynamic and reversible control over cell-cell interactions with unprecedented spatial and temporal resolution. First of all, we will focus on various light dependent protein interactions to mediate cell-cell contacts. The detailed characterization (strength, dynamics, interaction modes and orthogonality) of these new photoswitchable cell-cell interactions will provide the framework for the bottom-up construction of tissue-like structures. Secondly, we will use these photoswitchable cell-cell interactions to assemble cells into multicellular architectures with predictable and programmable organization. The dynamic and reversible nature of the photoswitchable contacts will allow us to locally alter interactions at any point in time, to rearrange and obtain asymmetric multicellular structures, which are typical of tissues. Finally, we will also explore how the photoswitchable cell-cell interactions alter cell behavior and signaling. Ultimately, this will pave the way for the bottom-up assembly of multicellular architectures, enabling us to control precisely and dynamically their organization in space and time as well as regulate how cells work together.

Keywords: photoswitchable,cell cell interactions
Functional organization of the multisensory motion system (ItsAllAboutMotion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

One of the most significant current discussions in the understanding of the human brain is the functional recruitment of some regions of the cortex for specific tasks, regardless the sensory modality (e.g. visual, tactile or auditory) in which the stimuli is received. The ability to perceive motion, among others visual properties, is a fundamental faculty of the human brain. The predisposition to detect motion is present since the first months of life and is one of the main prerequisites for a child’s healthy brain development. Brain lesions that impair the detection and processing of motion have a profound impact on daily activity. Consequently, visual motion processing is one of the most fundamental and well-studied systems in the human brain, canonically known to develop mainly for the purpose of visual perception. The aim of this proposal is to elucidate in humans whether the functional recruitment and specialization of the visual motion system is independent of the sensory modality in which the stimuli are perceived, to characterize the sensory independent functional mesoscopic architecture within the brain regions involved and to establish their causal role in perception. I will answer these questions using advanced methods such as ultra-high field fMRI at 7T, intracranial electrodes, transcranial magnetic stimulation and advanced neural based analyses. The integrated approach I propose here provides a unique multiangle perspective to investigate the neural substrate of multisensory processes. The fact that motion sensitive brain regions exhibit sensory-independent responses and that the same neuronal ensemble may respond to aspecific sensory features will challenge our notions on brain sensory segregation and functional development and will impact other high-level cognition studies at large. Moreover, it will provide essential knowledge for novel research on sensory substitution devices for rehabilitation in sensory-impaired individuals.

Keywords: motion processing,7t fmri,multisensory,functional specialization
Using causal discovery algorithms to boost subseasonal to seasonal forecast skill of Mediterranean rainfall (CausalBoost)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The Mediterranean region (MED) is a hotspot of anthropogenic climate change and impacts are probably already felt today; recent heatwaves and persistent droughts have led to crop failures, wild fires and water shortages, causing large economic losses. Climate models robustly project further warming and drying of the region, putting it at risk of desertification. The particular vulnerability of this water-limited region to climatic changes has created an urgent need for reliable forecasts of rainfall on subseasonal to seasonal (S2S) timescales, i.e. 2 weeks up to a season ahead. This S2S time-range is particularly crucial, as the prediction lead time is long enough to implement adaptation measures, and short enough to be of immediate relevance for decision makers. However, predictions on lead-times beyond approximately 10 days fall into the so-called “weather-climate prediction gap”, with operational forecast models only providing marginal skill. The reasons for this are a range of fundamental challenges, including a limited causal understanding of the underlying sources of predictability. The proposed research effort aims to improve S2S forecasts of MED rainfall by taking an innovative, interdisciplinary approach that combines novel causal discovery algorithms from complex system science with operational forecast models. This will overcome current limitations of conventional statistical methods to identify relevant sources of predictability and to evaluate modelled teleconnection processes. The outcomes of this project will (i) identify key S2S drivers of MED rainfall, (ii) systematically evaluate them in forecast models, (iii) derive process-based bias corrections to (iv) boost forecast skill. My strong background in both causal inference techniques and atmospheric dynamics puts me in a unique position to lead this innovative effort and to achieve real progress in reducing the “weather-climate prediction gap” for the MED region.

Keywords: s2s forecasting,mediterranean climate,causal discovery techniques,teleconnections,climate model evaluation
Utilizing an innovative chemical platform to defeat antimicrobial resistance (QTB4AMR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We tackle the challenges posed by the emergence of antimicrobial resistance (AMR) with a conceptually new approach. We have established a scalable chemical platform for the development of novel antibiotic resistance breakers (ARBs). Our compounds sensitize the pathogen and restore the effectiveness of standard-of-care antibiotics. By circumventing the painstaking process of discovering and developing new antibiotics, we bring forth a more cost-effective approach to confront the emergence of AMR. Allowing pharmaceutical companies to protect decades worth of R&D efforts and billions of euros in development costs, we present them with an attractive value proposition. Our platform enables the fast, high-yield production of ARBs against gram-positive bacteria (GmPcides). Our compounds have displayed effectiveness against two of the most threatening drug-resistant pathogens MRSA and VRE. Moreover, the compounds exhibit a strong in vivo synergy with two of the world’s most essential antibiotics Gentamicin and Vancomycin.

Keywords: antimicrobial resistance,mrsa,gram positive
A new integrated sustainable processing system for ‘metal from slag’ recovery with higher technical, economic, energy and environmental performance than existing recovery processes. (Ultroslag)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Slag is a by-product of metal smelting, and ~3.5 million tpa are produced globally in refining Non Ferrous Metals (NFM) and making alloys. Slag contains impurities and forms a protective crust of non-metallic & metallic oxides, and contains significant ‘free’ & alloyed metal (from 10 to 70% by weight). While slag can be used as aggregate, there are increasing concerns over ‘leaching’ of heavy metals into water courses from using these materials in civil engineering. While some metal can be recovered by re-melting slag (at very high temp), this is extremely expensive with very high energy burden which often makes recovery un-economic, but necessary. Landfill of slag is increasingly not an option. Our idea is to use a relatively new technology called ‘implosion’ to selectively break down and separate non-metallic components of slag from metallic particles. This will be combined with ultrasonic vibration sieving for accelerated recovery of metal from the finest fraction. This novel technology was originally developed to recycle waste glass by reducing it to fine ‘sand’, with uniform size and no ‘sharps’ compared to normal crushing techniques. This technology has not been applied commercially to other materials. Benefits to partners, endusers & society could be: • Rapid recovery of more metal from slag at relatively low cost • Strategic control of metal recovered rather than losing control thro’ export to ‘low cost’ economies • Enable smelters to recycle slag in-house, increasing their ‘Value Add’ while reducing ‘recycle-miles’ • 97% energy saving thro’ low cost mechanical separation rather than very high temp. melt recycling • Huge cut in carbon emissions from thermal energy saved and ‘recycle-miles’ saved The ultimate goal is to launch a new process in the market, through an innovative application of a relatively new technology to selectively break down the non-metallic components of slag from the metallic particles.

Keywords: slag ultrasonic metals leaching implosion crushing
Robotic fluorescent microscope for smear slide screening in Tuberculosis Diagnosis (Fluorobot)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Hungary
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2014-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ASK-M has been involved in the development and production of cutting edge medical microscopy devices for almost 20 years. We have now developed the prototype of the world’s first dedicated fluorescent robot microscope for Tuberculosis (TB) screening. This innovative device has the potential to be a breakthrough in TB diagnostics, an area identified as top priority by the WHO. This proposal aims a Phase 1 project demonstrating the economic and technological feasibility of Fluorobot. The Phase 1 project will pave the way for a comparative clinical study (Phase 2) as the last major step before the market introduction of the device. TB imposes a tremendous economic and social burden on these societies, communities and individuals of all ages and in all social classes. The lack of or inadequacy of diagnostic tools result in financial and opportunity losses through delays in diagnosis, misdiagnosis and the need for additional testing. Recently it has been demonstrated that low cost ultra-bright Light Emitting Diodes (LEDs) could be a viable alternative to mercury vapor (MV) lamps used in Fluorescent Microscopy. According to a recent WHO assessment, the sensitivity of LED based microscopy is 10 percent higher than conventional Ziehl-Neelsen microscopy. The FLUOROBOT concept aims to increase the sensitivity of LED based microscopy further by approximately 10% through automation. Users and use cases targeted by FLUOROBOT can be divided into two major groups: 1) in developing high burden countries: to be used by TB labs for same-day screening in the highly endemic areas, where a cheap and fast screening method with a robust device is required; 2) in Europe and other established market economies: to be used by TB laboratories for screening during the treatment – there are relatively few cases, but cheaper screening is required for regular checking of the treatment effectiveness and confirmation of culture results.

Keywords: improved diagnostics,tuberculosis,automated microscopy,led based microscopy,pattern recognition,high burden countries