Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Climate-Control System to Extend Range of Electric Vehicles and Improve Comfort (XERIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Italy,Germany,Spain,Italy,Belgium,Belgium
Call: Optimised and systematic energy management in electric vehicles (H2020-GV-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 4621280.0
EU funding (EUR): 4621279.75
Participants: 9
Project status: CLOSED

The limited capacity of electric batteries combined with the substantial amount of energy needed to run auxiliary equipment dramatically affects range capability of electric vehicles (EVs). For instance, the climate control system in summer conditions can absorbs up to 40-60% of the available energy. The aim of the project is to develop an energy friendly climate control system capable to reduce of at least 50% the energy used for passenger comfort all over the year (i.e., heating, cooling and dehumidifying). Actually, in summer conditions air is dehumidified and cooled by best available technologies that use climate control systems based on a Vapor Compression Cycle (VCC), which cools air below its dew point. Alternatively, desiccants are used as an energy efficient way to dehumidify air without cooling it below its dew point, which allows to control temperature and humidity independently. In our project we plan to exploit technologically the desiccants properties by using aqueous solutions of desiccants (e.g., LiCl, CaCl2) housed in a membrane contactor. Our idea is to develop a hybrid system in which air can be dehumidified without the need to be cooled below its dew-point. This will be done by combining a liquid desiccant cycle (which deals with the latent load) with a traditional vapour compression cycle (which faces the sensible load). In fact, in such a system the VCC would operate at higher refrigerant evaporation temperature and at lower condensation temperature. The core of the system is an innovative highly compact and energy efficient three-fluids-combined-membrane-contactor that simultaneously works with air, desiccant solution, and refrigerant. Specifically, the climate control system will be capable to - reduce more than 50% the energy used for passenger comfort, - have a lifetime longer than 10 years, - easy industrialization and customization for EVs currently on the market, - cost from 1,200 to 3,000 Euro. Project Coordinator: GVS SPA, IT

Keywords: electric vehicles range,hybrid climate control system,air conditioning electronic control system,three fluids membrane contactor,hydrophobic membranes
Development of E2E Maintenance architecture process and methods enabling a reliable and economic air transport system (DEMETER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Netherlands
Call: Process and Methods for E2E Maintenance Architecture development and demonstrations and solutions for technology integration (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 1749911.25
EU funding (EUR): 1749911.25
Participants: 2
Project status: CLOSED

The DEMETER proposal addresses the topic JTI-CS2-2014-CFP01-LPA-03-01 “Process and Methods for E2E Maintenance Architecture development and demonstrations and solutions for technology integration.” Passengers leaving and arriving on time is the service that an economic efficient and reliable transport system needs to provide. Aircraft scheduled and unscheduled maintenance continues to disrupt operations in Europe and reduces the asset utilization. In Europe 5.8% of all flights are delayed due to direct aircraft technical causes and consequential reactionary-rotational delays on subsequent flights. Consequential cost are estimated at 2.8b€ reducing the economic efficiency of the main actors. DEMETER support the development for future’s End-to-End (E2E) maintenance architecture, which replaces the current systematic scheduled maintenance by on-condition maintenance: To reach this goal DEMETER will provide application of structure health monitoring (SHM) technologies, conditions based maintenance principles, system prognostic solutions based on aircraft data, improvement of maintenance execution efficiency at turn around and at scheduled maintenance intervals and service solutions supporting the above providing maintenance economic efficiency enhancement. DEMETER will be strongly integrated in WP3.6 “Maintenance” and will develop and perform the architecture and technology evaluation. The DEMETER Consortium, composed of DLR and NLR, addresses research activities requiring multiple complementary skills that both research centres have capitalized not only as being preferential long-term strategic partners of the European aerospace industrial leaders, but also as acting as Partners of several EU-funded projects.

Keywords: maintenance,shm solution,vandv,evaluation,condition based maintenance concept
Emergent topology in photon fluids (emergenTopo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1999973.0
EU funding (EUR): 1999973.0
Participants: 2
Project status: SIGNED

The discovery of topological phases of matter has revolutionised the understanding of solid state physics in the past 40 years. Their main hallmark is the appearance of propagating edge states robust to backscattering at the interface between two solids of different topologies. This paradigm has been able to successfully ex-plain electronic phenomena such as the universal edge transport in the quantum Hall effect and the exist-ence of topological insulators. Recently, these concepts have been brought to photonic materials. The flexi-bility to implement engineered Hamiltonians along with the direct optical access to all relevant observables, has made of photonic systems an extraordinary platform for the study of topological phenomena, and prom-ises exceptional applications in integrated photonics. So far, the vast majority of topological phases observed in any system (solid state, cold atoms or photons) arise from single particle dynamics. The experimental observation of new topological phases emerging from particle-particle interactions remains one of the greatest challenges of topological physics. The first goal of this project is to experimentally unveil novel topological phases in photonic lattices emerging from photon-photon interactions. A second scenario of high potential interest is that of Floquet topological sys-tems, in which topological phases are induced when a trivial system is periodically driven in time. The sec-ond goal of this project is to implement novel topological phases in photonic lattices subject to periodic temporal modulations, and to explore their behaviour in the presence of interactions. To attain these goals, we will employ different photonic platforms with significant photon nonlinearities, and we will develop a new ultrafast detection technique capable of resolving the dynamics of topological excitations. This project will unlock the door to the new field of nonlinear topological photonics.

Keywords: topology,topological insulators,analogue quantum simulation
The function and biomarker potential of mitochondrial microRNAs in hypertension (MITO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-03
End date: 2022-08-02
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Hypertension is an extreme public health problem affecting nearly one third of the World’s adult population. Most cardiovascular diseases are provoked by hypertension resulting in an estimated 9.4 million deaths every year. Surprisingly, the diagnosis of hypertension has changed very little over the past 100 years - just using a stethoscope definitely needs refining. Furthermore, the epidemic proportion of hypertension worldwide pinpoints the necessity for the discovery of fresh antihypertensive therapies. Thus the main objective of the MITO project is to discover novel methods to improve healthcare of hypertension patients. For this we will investigate the circulating pool of microRNAs (small RNA molecules present in the blood, regulating gene expression) - we hypothesize that particularly mitochondrial microRNAs play a critical role in hypertension development. Easily obtainable in the blood, microRNAs constitute an accessible source of biomarkers and therapeutic targets for clinical application. The research plan envisages three scientific work packages dedicated (1) to the discovery of candidate microRNAs associated with hypertension by using small RNA sequencing in 30 hypertensive patients and 30 controls, (2) the validation of candidate microRNAs in a group of 540 participants (paying attention to sex specificities), and (3) to the functional assessment of the role of microRNAs in hypertension development. While the first two parts of the project will be conducted at the host institution in Luxembourg, functional studies will involve three secondments to partner institutions in Denmark, Germany, and France. A successful outcome will have implications ranging from contributing to satisfy the need for novel methods to stop the progression of hypertension, to a better understanding of the role of microRNAs in hypertension development, to the training of a young East European researcher to pioneer development in a research field just emerging in her home country.

Keywords: personalized medicine,translational research,cardiovascular disease,hypertension,biomarker,microrna,mitochondria
New MilliDrop Analyzer: miniaturized and faster clinical microbiology testing in only one drop (MilliDrop)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: France
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MilliDrop pioneering millifluidic technology to study microbes will massively advance the fields of microbiology worth €7bn worldwide. Manipulation of microbial cell culture in only one droplet (~100nl), together with automation and extraordinary parallelisation (1000 samples), stands to deliver new products for medicine and biotechnology. It will close the gap from lab to market and revolutionize the microbiology analysis after hundreds of years of standard Petri dishes technology. The MilliDrop Analyzer is a unique, miniaturized and fully automated instrument for microorganisms’ fast culture and analysis. Each microorganism is grown in one droplet in a capillary containing several thousand droplets separated by air bubbles. Each droplet is monitored and measured in real time, enabling identification of infectious stains much faster than other existing technologies (6h vs 24h). Followed by immediate antibiotic susceptibility testing (AST) in the same instrument, it allows to obtain AST result in less than 12h after receiving the patient sample, instead of standard 48h. It opens extraordinary opportunities in clinical diagnostics enabling earlier and more precise diagnosis of infectious disease, giving a possibility to select and dose specific antibiotic early enough. It will reduce therapeutic failures by 60% and helping to combat antibiotic resistance which is a highly growing European and worldwide health challenge. The proposed SME Instrument objective is to develop, validate and industrialize a new version of Medical Device Analyzer for in vitro diagnostic (IVD) clinical microbiology market. The first generation dedicated to the research and development market is already in the industrialization process. IVD version will be launched in 2020 and will enable the company to become European champion and to fast track its business to €11.8M and 60 job creation in 2023.

Keywords: millifluidic,automation,droplet,microbiology,in vitro clinical diagnostic,clinical microbiology testing,antibiogram,antibiotic resistance
COMPONENTS’ AND MATERIALS’ PERFORMANCE FOR ADVANCED SOLAR SUPERCITICAL CO2 POWERPLANTS (COMPASsCO2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Germany,Belgium,Belgium,Finland,France,France,Czechia,United Kingdom
Call: Novel high performance materials and components (RIA) (H2020-NMBP-ST-IND-2020-singlestage, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 5996892.5
EU funding (EUR): 5996892.5
Participants: 12
Project status: SIGNED

COMPASsCO2 aims to integrate solar energy into highly efficient supercritical CO2 Brayton power cycles for electricity production. Concentrated solar radiation is absorbed and stored in solid particles and then transferred to the s-CO2. In COMPASsCO2, the key component for such an endeavor shall be validated in a relevant environment: the particle-s-CO2 heat exchanger. To reach this goal, the consortium will produce, test, model and validate tailored particle-alloy combinations that meet the extreme operating conditions in terms of temperature, pressure, abrasion and hot oxidation/carburization of the heat exchanger tubes and the particles moving around/across them.

Keywords: supercritical co2 bryton cycle,concentrated solar power,particle,sco2 heat exchanger,novel alloys,novel particles
Unraveling The Immune Landscape In Uveal Melanoma (UTILIUM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.
India and the Indian Ocean in the Early Decolonial Period: Archipelagic Imaginaries, 1950s-1970s (IATIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: South Africa,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2024-06-14
Duration (months): 36.0
Total project cost (EUR): 233163.84
EU funding (EUR): 233163.84
Participants: 2
Project status: SIGNED

The project IATIO mobilises the concept of ‘archipelagic imaginaries’ to examine Indian intellectual and literary cosmopolitanism in the Indian Ocean during the 1950s-1970s. The research shifts focus from teleological readings of Indian Ocean history and territorial perspective on postcolonial Indian culture, to a renewed investment in archipelagic theory and geocritical approaches. The temporal framework of the project ranges from around the time of the post-World War II decolonisation to the late 1970s, a period of far-reaching political, cultural and economic change for the entire Indian Ocean region. The project aims to advance a non-territorial epistemological framework for theorising postcolonial India through an investigation of the conceptual, imaginative and material Indian Ocean geographies inhabited by Indian intellectuals, writers and other cosmopolitan voices. It will do so by employing an interdisciplinary methodology that combines tools and insights from history, literary criticism and cultural studies, to engage in close reading of intellectual journals and the popular press, works of fiction, and selected case studies of material Indian Ocean sites of cosmopolitan encounters. The fellowship will be based at two leading academic institutions, King’s College London (UK) and the University of the Witwatersrand (ZA), and will take the researcher to further Asian and African countries for archival research. It will enhance the profile and the innovative potential of the researcher, strengthening his competence in interdisciplinary methods in the humanities and social sciences through personalised training, and providing the opportunity to develop a solid and internationally competitive track record. The project will also create a substantial institutional link between KCL and Wits, with KCL emerging as a UK hub in the global academic Indian Ocean studies network.

Keywords: indian ocean studies,archipelagic theory,indian anglophone literature,cultural production,national literature,afro asian movement,bandung era
UNique Refinery Approach to Valorise European Lignocellulosics (UNRAVEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Germany,Austria,Ireland,Germany,Belgium,Finland,France,France,Netherlands,Netherlands
Call: Innovative technologies for the pre-treatment and separation of lignocellulosic feedstock and complex composition streams into valuable fractions while maintaining key characteristics (H2020-BBI-JTI-2017, 2017)
Start date: 2018-06-01
End date: 2022-05-31
Duration (months): 48.0
Total project cost (EUR): 3717295.75
EU funding (EUR): 3603545.0
Participants: 13
Project status: CLOSED

UNRAVEL aims to develop advanced pre-treatment, separation and conversion technologies for complex lignocellulosic biomass to produce usable lignin fragments, and monomeric sugars from the cellulose and hemicellulose fraction suitable for biochemical conversions. The technologies will be scaled up from lab (TRL 3) to pilot plant (TRL 5). UNRAVEL will achieve a breakthrough in the valorisation of lignocellulosic biomass by: • Utilizing complex lignocellulosic biomass sources such as forest residues, bark, straw, and nut shells • Recovering valuable components by feedstock pre-extraction prior to fractionation • Achieving at least 80% lignin yield, 90% glucan recovery from the cellulose and 80% yield of monomeric hemicellulose sugars by utilizing the TNO FABIOLA™ low temperature, energy-efficient acetone based fractionation process • Purifying the hemicellulose hydrolysate and qualifying it for fermentation into chemical building blocks • Developing lignin depolymerisation technologies • Establishing high-value lignin applications through the production of lignin-based PUR & PIR foams and lignin-based additives in bitumen for roofing applications • Demonstrating a 30% OPEX and 15 % carbon footprint reduction of the pre-treatment UNRAVEL will develop an integrated cross-sector value chain by bringing together specialists with expertise on feedstock composition, chemical pulping and pre-treatment, enzymes production, polymer chemistry, separation and reactor engineering, techno-economic and sustainability assessments and knowledge dissemination and exploitation and communication. The active involvement of three SME's and two large enterprises, active in wood pulping and the production of lignin-based building materials, strengthens a market-driven approach and commercial exploitation and implementation of the results generated in the UNRAVEL project.

Keywords: pre treatment,fractionation,lignocellulosic,lignin,polyurethane,bitumen,enzymatic hydrolysis,scale up,pilot plant