Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrafast Spatiotemporally-Encoding: A Superior Approach to Cancer Diagnosis by Non-Invasive Diffusion-Weighted MRI (SPENmr)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This proposal aims at commercializing a new method that can improve the detection and diagnosis of breast cancer. Using ultrafast magnetic resonance (MR) acquisition schemes that span off our UltraNMR ERC AdG award, we have found ways to exploit our Spatiotemporally-Encoded (SPEN) principles together with diffusion measurements, for the rapid, safe and non-invasive diagnosis of breast malignancies. This SPENmr PoC could provide much cleaner, artifact-free alternatives than existing standards; porting these methods into clinical use could reduce unnecessary biopsies, eliminate side-effects associated from contrast agent injections, expand the base of subjects that can be diagnosed without surgery, and improve the specificity of methods based on either mammography, ultrasound or contemporary MRI. All these benefits would simply require operating acquisition and processing software packages that will arise from this project, on any of the tens-of-thousands of clinical MRI scanners used nowadays worldwide for breast scanning. We consequently envision a large potential market, and a product whose successive refinements could have a lifetime of decades. Moreover, preliminary results indicate that the principles discussed in this proposal could be extended from breast to other human organs possessing an organized ductal/glandular structures –kidneys, prostate, pancreas– to analyses of stroke and to functional MRI.

Keywords: diffusion weighted mri,cancer diagnosis,ultrafast magnetic resonance,medical imaging
New Generation ADAS for Enhanced Driving Experience (e-Awake)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The latest generation of Advanced Driving Assistance Systems (ADAS) will accelerate the trend towards zero accident vehicles, highly automated driving (HAD) and an associated better road utilization. Hence, preventing accidents and automation of tasks in progressively more complex driving situations require innovation in perceiving the environment, the vehicle-state, and the reasoning about these. This can be done by the usage of multiple sensor technologies, complementing and reinforcing each other. The optimal use of such a huge amount of heterogeneous information requires innovations in both the involved component technologies and in the system architecture concepts. e-Awake project seeks to bring to the ADAS market an innovative product that uniquely addresses the aforementioned challenge. The overall goal of the project is to integrate, test, standardize and industrialize a high performance embedded system that will allow vehicle integrators to easily design and tailor their solutions to the challenging new trends and demands in ADAS and HAD markets. e-Awake will rely on in-house developed algorithms for ADAS and HW/SW co-design methods under a new paradigm, where instead of several dedicated chips, a single device supports a homogeneous software-centric architecture with optimal hardware and software partitioning for functional acceleration. The resulting -automotive qualified- embedded computing platform shall provide significant enhancements not only in performance (100x) and power consumption (x2) but also in terms of cost-efficiency, scalability and flexibility -resulting in at least a 30% reduction of development costs. Trough e-Awake project, IXION will develop and industrialize HW/SW technology for new generation ADAS and highly automated vehicles, where it aims to be a relevant actor in the market as 2nd tier in the upcoming 4-6 years.

Keywords: adas,highly automated vehicles,embedded system,automotive qualified
On-chip fabrication of solid state nanopores for high throughput single molecule analysis (NanoPoreFab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nanopore sensing has a broad range of potential applications (e.g. detection of trace amounts of substances in drug delivery/cancer diagnosis/tests for nanotoxicity and infectious diseases, next generation of DNA sequencing and protein fingerprinting) due to its outstanding sensitivity for label-free single molecule analysis. The lack of a reliable high throughput fabrication process for uniformly sized nanopores has become a serious bottleneck for research, industry and economy. With the proposed innovation project, Ionera Technologies aims to push nanopore analysis to an industrial level by developing a high throughput fabrication process for nanopores in solid-state materials. In this Phase 1 feasibility study, Ionera will combine a nano-fabrication process recently developed on a laboratory scale with its proprietary MECA technology platform to deliver the proof of technology for a parallel, industrially applicable fabrication of solid state nanopores. This will be accompanied by an assessment of the economic viability of a high throughput platform for in situ nanopore fabrication and analysis. While so far, solid state nanopores are only available for a small group of experts in the material sciences, we put this exciting new research tool into the hands of all people who are eager to use them as a highly sensitive single molecule sensor for a wide range of applications but lack the expensive equipment and expert knowledge for standard SSN fabrication processes. Ionera’s envisioned product line will be the first one on the market that offers automatic parallel fabrication of customizable nanopores at a minimum cost. Market for the products is the global molecular diagnostics market, with four main segments: Academic and research facilities (niche market but easily accessible for market entrance), biotechnology companies (medium volume market), contract research organizations (medium volume market) and the pharmaceutical industry (high volume market).

Keywords: nanopore analysis,solid state nanopores,meca technology,high throughput,enabling technology
A bioengineered, naturally-derived, sustainable biocide for breaking down organic biofilms formed by drug-resistant bacteria. (ABD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aequor's ABD (Aequor Biofilm Dispersant) represents a significant leap forward in the arms race between modern medicine and drug-resistant bacteria. The biofilm is the first line of defence for these drug-resistant microorganisms, a polymer-like structure of proteins and secretions that protects the colony from virtually everything but burning or scraping it away. ABD does away with this problem in dramatic fashion. A natural biocidal agent derived from marine microorganisms, ABD is devastating for bacterial contamination, but gentle enough to be used as a supplement for antibiotic treatments. It is 99.99% effective at removing existing biofilms, prevents 99.99% of new biofilms from forming, and inhibits the growth of new bacterial colonies by over 92%. Lonza Group AG has verified this stellar performance in-vitro. Aequor intends to use the funds from the SME instrument to study the EU and global market for biocides further, and to dig deeper into markets for antibiotic supplements. Further it will carry out growth projections and examine the process for clinical trials in-depth.

Keywords: biofilm,drug resistant,mrsa,staphylococcus,improved healthcare,healthcare related infections,biocides,antibiotics,antibiotic resistance,clean technology,blue growth
CAPSizing ICE caps: identifying tipping points through global modelling (CAPSICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-28
End date: 2021-02-27
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Ice caps have been major contributors to sea-level rise over the past decades and also in the coming century they are projected to further lose a substantial part of their volume, maintaining their position as one of the main sea-level rise contributors. One of the drawbacks of these projections, however, is that they are based on approaches that strongly simplify ice cap processes by relying on volume-area scaling methods or parameterisations derived from observations on mountain glaciers. Consequently, these projections fail to provide insights on feedback processes that can have an important impact on the future evolution of ice caps. Within this project, I want to implement GloCAP3D, the first global 3-D ice cap evolution model in which surface mass balance and ice dynamics are explicitly accounted for, in order to improve future projections of ice caps. Firstly, I will focus on calibrating GloCAP3D, which is a crucial step to ensure accurate future ice cap projections. For this, remote sensing products and other increasingly available datasets will be included. Secondly, I will assess the role of tipping points in the future evolution of ice caps and identify potential points-of-no-return, beyond which the loss of individual ice caps is irreversible. Particular focus will be on tipping points related to the surface mass balance - elevation feedback and on tipping points resulting from a potential strong reduction in the refreezing potential. The incorporation of ice dynamics will also allow to further quantify the mass loss through frontal calving, which can regionally be a major annual mass loss driver. Finally, through this novel interdisciplinary approach it will be possible to provide improved estimates on the future sea-level contribution from ice caps. Given project’s unique nature, its outcome is anticipated to be pivotal for a number of future works, including the upcoming Intergovernmental Panel on Climate Change Assessment Report.
oPtoelectROnic Properties of Hybrid pErovskiTes (PROPHET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-10
End date: 2022-05-01
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Over recents years hybrid halide perovskites have attracted strong interest in the solar cell community as a result of their high-power conversion eciency and the opportunity to realise a low-cost as well as industry-scalable technology. Nevertheless, most of the progress has been through empirical device improvements, and a number of key questions still remain unanswered. Open issues include the optimal chemical composition of the materials, ion migration, scalable fabrication routes, device architecture and stability in operation. The goal of PROPHET is to directly relate the optoelectronic behaviour of metal halide perovskites to their chemical and morphological properties by investigating their photophysics on a range of different length and time scales. New approaches in the characterisation of the materials will be used in the action, leading to a deep understanding of the carrier transport and recombination processes. The host lab is at the forefront of the development of advanced characterisation methods for optoelectronic devices, particularly solar cells, with an outstanding expertise on hyperspectral luminescence and time resolved fluorescence imaging, which will be extensively used during the action. To further expand the capabilities of luminescence images datasets signal will be treated by multivariate statistical analysis, with the aim of identifying possible correlations between different features within the material. This innovative approach is expected to provide new insights and a more detailed and comprehensive knowledge about the local optoelectronics properties of halide perovskites. These techniques in combination with chemical and morphological characterisation methods will be used to investigate degradation processes under operational condition and the issues raised by the scaling-up of the cells. The results of the action are thus expected to gain insight and better guidelines for the right material choices as well as film processing.

Keywords: hybrid perovskites,space and time resolved pl,ageing,up scaling
Development of a chemical biology toolbox for deciphering the ubiquitin code (Ubl-tool)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2027-02-28
Duration (months): 66.0
Total project cost (EUR): 1997717.0
EU funding (EUR): 1997717.0
Participants: 1
Project status: SIGNED

Cells respond to external and internal stimuli by dynamically altering the functional status of existing proteins via post-translational modifications (PTMs). One of the most common and versatile PTMs in eukaryotic cells is represented by the covalent attachment of the 76-amino acid protein ubiquitin (Ub) to substrate proteins (ubiquitylation). Substrate modifications range from a single Ub moiety being attached to a protein of interest to complex polymeric Ub chains that can also contain Ub-like proteins (Ubls). Ubiquitylation plays pivotal roles in nearly all aspects of eukaryotic biology and cells dedicate an orchestrated arsenal of enzymes to install (writer proteins), translate (reader proteins) and reverse (eraser proteins) these modifications. The entirety of this complex regulatory system has been coined the Ub code. As many different human diseases, including different types of cancer and neurodegenerative diseases are being linked to dysfunctions in Ubl-related pathways, it is of utmost importance to decipher the Ub code. Within Ubl-tool we devise a modular and interdisciplinary chemical and synthetic biology platform for studying aspects of ubiquitylation that are challenging or impossible to be addressed by more traditional technologies. We will develop innovative toolkits for generating defined Ubl architectures, including mixed, branched and hybrid Ubl chains and we will apply these tools for identifying novel reader proteins as well as for studying the functional impact of these complex types of modifications on critical cellular processes. Given its fundamental importance in eukaryotic biology, the Ub system has attracted considerable interest and promise as therapeutic target. We aim at identifying new drug targets within the Ub system by developing in cellulo activity-based probes that allow profiling activities and specificities of Ub eraser enzymes, laying thereby the foundation for the discovery of next-generation therapeutics.

Keywords: genetic code expansion,post translational modifications,unnatural amino acids,chemoenzymatic approaches,ubiquitylation
Grenoble Quantum Engineering Doctoral Programme (GreQuE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria,Germany,Switzerland,Belgium,France,France,Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-09-01
End date: 2022-12-31
Duration (months): 64.0
Total project cost (EUR): 3924000.0
EU funding (EUR): 1962000.0
Participants: 23
Project status: CLOSED

Quantum engineering is a novel domain of research, built on fundamental research carried out in the last 20 years all over the world. Quantum technologies offer radically new materials and devices for the next century, in sectors such as security, energy, communications, or healthcare. To transform such disruptive scientific concepts into real life benefits it is crucial to develop research aiming at higher technology readiness levels. To ensure that Europe takes the leadership in this coming quantum revolution, we must train next generation quantum engineers, by offering doctoral training in interconnected domains with the highest scientific standards, while equally providing an opening to the industrial world. Grenoble is world renowned for its fundamental research institutes in condensed matter physics, nanosciences, computer sciences & mathematics as well as its high-tech innovative companies ranging from local start-ups to multinational groups. Grenoble area hosts 25 000 academic and industrial researchers, and more than 60 000 students. Grenoble’s ecosystem is ranked within the top 5 innovative cities in nanotechnologies worldwide and 1st in Europe. Grenoble Quantum Engineering (GreQuE) novel Doctoral Programme will grant 25 PhD projects hosted in Grenoble research institutes in which each student will benefit from a 2 to 6 months placement in a European company. 17 SMEs & large groups have in 5 countries committed to offer such placement to our students in accordance with their PhD project. GreQuE DP is expected to: 1.Attract excellent candidates from worldwide universities, 2. Train top level quantum researchers willing to work at the industrial world to turn quantum technologies in important economic and societal impacts, 3.Improve career opportunities at short and long-term scale by immersing the ESRs in the engineering culture, 4.Disseminate a comprehensive doctoral programme prototype based on private sector collaboration to other fundamental sciences.

Keywords: quantum engineering,physics,nanotechnologies,computer sciences,interdisciplinary and intersectoral training
Insects For a Sustainable Aquaculture (IFASA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: France
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Question: What is the main cost driver of aquaculture? Answer: Feed. As protein intake of farmed fish comes mainly from wild caught animals and transgenic soybean flours, feed cost accounts for up to 60% of sales. Overall, commercially available solutions are limited in quantity, nutritionally unsatisfactory, financially unbalanced and ecologically disastrous. Innovafeed is an ambitious start-up in the aquaculture industry, set to revolutionize how fish farmers and ingredient manufacturers apprehend feeding, by bringing economic and environmental sustainability to insect farming. IFASA’s objective is to scale-up the innovative, sustainable, proprietary and cost-effective insect-based production technology the company has developed. It will allow the transformation of low-value agricultural by-products, into high quality nutrients for aquaculture, thereby answering the needs expressed by feed companies, fish and land farmers. This technology is based on Innovafeed’s and its partners’ long lasting expertise in optimizing an insect rearing process and obtaining a product answering fish nutritional needs, as embodied in a first lab-scale production unit able to produce small batches of insects. It also strongly benefits from the company’s market proximity, as 85% of fish farmers already contacted have expressed a strong interest for the project and 12 asked to be supplied with some insect-based feed as soon as possible. During phase 1, Innovafeed will scale-up its farming unit by (a) optimizing the egg production and breeding systems, (b) pursuing regulatory and scientific lobbying initiatives, (c) refining its IP and business strategies, (d) testing the nutritional properties of its feed and (e) continuing on site tests to prepare for phase 2. The main deliverable will be an updated business plan enabling Innovafeed to seize this huge business opportunity. This feasibility study is an essential first step before large-scale industrial production.

Keywords: insect protein aquaculture farming sustainable by products