Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis (MetCAF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1281958.75
EU funding (EUR): 1281958.75
Participants: 1
Project status: CLOSED

Mortality from breast cancer is almost exclusively a result of tumor metastasis. Since advanced metastatic cancers are usually fatal, understanding the biology of tumor metastasis is the most significant challenge in cancer research today. It has become clear that the microenvironment of tumors is crucial in supporting tumor growth. Nevertheless, the role of the metastatic microenvironment in facilitating metastatic colonization is largely unknown. We recently uncovered a novel role for Cancer-Associated Fibroblasts (CAFs) in mediating tumor-promoting inflammation. However, the role of CAFs in the formation of a permissive metastatic niche that enables the growth of disseminated tumor cells is unresolved. I propose to systematically investigate, for the first time, the molecular changes in CAFs that facilitate metastases formation, which may lead to the discovery of novel targets for cancer therapeutics. To achieve this goal, I will integrate tumor biology knowledge and the unique expertise of my lab: we will combine novel mouse models of spontaneous lung metastasis of breast cancer, imitating the clinical setting, with multi-transgenic reporter mice that enable origin tracing and unbiased analysis of fibroblast sub-populations. By performing a comprehensive molecular and functional characterization of fibroblast co-evolution during metastases formation and analysis of breast cancer patient cohorts, we will uncover the dynamic changes in CAFs at the metastatic niche, identify the origin of metastatic CAFs, and elucidate the signaling pathways that govern their functional role in breast cancer metastasis. Molecular understanding of the early stages of tumor metastasis is an essential prerequisite for the discovery of novel therapeutic targets. Achievement of the proposed goals will shed light on a central conundrum in cancer biology and open new horizons for the development of novel therapeutics that will transform cancer into a chronic, yet manageable disease.

Keywords: cancer associated fibroblasts,breast cancer,metastasis,inflammation,microenvironment,fibrosis
Thin Film Reversible Solid Oxide Cells for Ultracompact Electrical Energy Storage (EPISTORE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Switzerland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 4599128.75
EU funding (EUR): 4599128.75
Participants: 15
Project status: SIGNED

In the last decades, advanced thin film technology has enabled a wide range of technological breakthroughs that have transformed entire sectors such as electronics and lighting by the implementation of outstanding nanoscale phenomena in reliable products that involve ultralow contents of critical raw materials (CRMs). EPISTORE aims to revolutionize the energy storage sector by developing pocket-sized kW-range stacks based on thin film reversible Solid Oxide Cells (TF-rSOCs) that will be able to efficiently store renewable electricity for applications where the use of batteries is inefficient due to size constraints or long term storage requirements, e.g. off-shore power generation or transportation. Nanoscale breakthroughs and never explored materials will be combined in revolutionary TF-rSOCs giving rise to radically new ultracompact and fast response Power-to-Gas and Power-to-Power storage solutions with superior performance (hydrogen production of 10kg/l per hour and specific power of 2.5kW/kg) and negligible use of CRMs (50mg/kW). In order to enable this science-to-technology step forward, our nano-enabled TF-rSOCs will be integrated in scalable silicon technology to show their viability as a potentially low-cost new paradigm of large-scale energy storage. The EPISTORE project addresses this challenging objective by building an interdisciplinary research consortium that includes consolidated and emergent leading researchers in modelling, micro- and nano-technologies, materials science and energy together with high-tech pioneer SMEs that cover the whole value chain and possess unique capabilities to develop kW-range modular stacks for real applications. Moreover, the structure and communication strategy have been designed to make EPISTORE a lighthouse project for boosting this novel storage paradigm and building an innovation ecosystem founded on advanced thin films applied to energy technology.

Keywords: reversible solid oxide cells,thin film,nanoionics
Battery Interface Genome - Materials Acceleration Platform (BIG-MAP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Future Battery Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Estonia,Italy,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Belgium,Switzerland,Switzerland,Poland,Sweden,Sweden,Sweden,Norway,Slovenia,France,France,France,France,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Novel methodologies for autonomous discovery of advanced battery chemistries (H2020-LC-BAT-2020-3, 2020)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 19997812.5
EU funding (EUR): 19997812.5
Participants: 38
Project status: SIGNED

Today, energy production and transport are evolving fast to meet challenging environmental targets and growing demand. The Achilles’ heel is energy storage, which is incapable of providing both low cost and high-performance solutions. The answer is not a simple evolution of existing batteries but disruptive technologies that must be discovered fast. The BIG-MAP vision is to develop a modular, closed-loop infrastructure and methodology to bridge physical insights and data-driven approaches to accelerate the discovery of sustainable battery chemistries and technologies. BIG-MAP’s strategy is to cohesively integrate machine learning, computer simulations and AI-orchestrated experiments and synthesis to accelerate battery materials discovery and optimization. The project will be a lever to create the infrastructural backbone of a versatile and chemistry-neutral European Materials Acceleration Platform, capable of reaching a 10-fold increase in the rate of discovery of novel battery materials and interfaces. To succeed in this unprecedented international initiative, the BIG-MAP consortium covers the entire battery discovery value chain from atoms to battery cells, totaling 34 partners from 15 countries and spanning world-leading academic experts, research laboratories and industry leaders. The consortium is a joint European battery community effort, and the large-scale European Research Initiative BATTERY 2030+ stands united behind the BIG-MAP consortium. In addition to 13 core partners from BATTERY 2030+, the BIG-MAP consortium includes 21 leading European partners with complementary battery skills and essential competences from critical research areas such as quantum machine learning, deep learning and autonomous synthesis robotics. All partners will work to create an innovative methodology relying on unique competences and cross-cutting initiatives to deliver a shared infrastructure and 12 key demonstrators to showcase the value of AI-orchestrated materials discovery.

Keywords: materials acceleration platform,battery value chain,artificial intelligence,machine learning
Sanskrit Śaiva Intellectuals in the Empire: Innovations, Textual Practices and Religious Interactions in the Late Vijayanagara Period (SSIIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project entitled ‘‘Sanskrit Śaiva Intellectuals in the Empire: Innovations, Textual Practices and Religious Interactions in the Late Vijayanagara period’’ examines the transformative role of Sanskrit Śaiva intellectuals in reshaping the religious landscape of South India during the late Vijayanagara period, i.e., from the mid-fifteenth century to the end of the sixteenth century. It is intended to be the first in-depth study of the intellectual history of two influential Śaiva schools of philosophical theology―Śivādvaita Vedānta and Vīraśaivism―on the basis of a rigorous philological and contextual analysis of selected Sanskrit and vernacular textual sources as well as epigraphic material. The evidence will be discussed in terms of the schools’ major doctrinal and philosophical positions, textual practices, as well as mutual influences and interactions with other religious groups. The aims of this project are: 1) to assess the impact of Sanskrit Śaiva intellectuals on the broader intellectual and religious world of the late Vijayanagara period, and their relation to the Vijayanagara royal court; and 2) to shed new light on the complex relationships between the various religious groups active during the last decades of the empire, in a context of increasing sectarian debates and dramatic socio-cultural transformations. The project will be carried out at the University of Oxford, one of the most renowned centres in Europe for the study of late medieval and early modern Sanskrit intellectual history.

Keywords: sanskrit language and literature,indian intellectual history,religious studies
Exploiting Energy Flow in Plasmonic-Catalytic Colloids (CATALIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The aim of CATALIGHT is to use sunlight as a source of energy in order to trigger chemical reactions by harvesting photons with plasmonic nanoparticles and channelling the energy into catalytic materials. Plasmonic-catalytic devices would allow efficient harvest, transport, and injection of solar energy into molecules. To achieve this, imaging the energy flow at the nanoscale will be crucial for establishing the true potential of plasmonics, both in the context of yielding fundamental knowledge about the light-into-chemical energy conversion processes, and for moving from active towards efficient reactive devices within nanoscale environments. CATALIGHT has roots in three underlying components, making this project an interwoven effort to break new grounds in a crucial field for the further development of nanoscale energy manipulation: A) Super-resolution imaging of the energy-flow at the nanoscale – with a view to unravel the most efficient mechanisms to guide solar energy into catalytic materials using plasmonic structures as photon harvesters. B) Scaling-up this process through the fabrication of hierarchical photocatalytic colloids – using image-learning for the design of colloidal sources for energy manipulation. C) Light-into-chemical energy conversion – boosting efficiencies in environmental and industrial catalytic processes using tailored photocatalysts. The outcomes of this project will not only yield a substantial amount of fundamental knowledge in these crucial areas for the further development of the field, but also provide directly exploitable results for the applied sciences, particularly photocatalysis and fuel cells.

Keywords: plasmonics,super resolution microscopy,interfaces,photo catalysis,colloidal chemistry
Securing against intruders and other threats through a NFV-enabled environment (SHIELD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Italy,Spain,Italy,Spain,Greece,Greece,United Kingdom,Luxembourg,Portugal
Call: Information driven Cyber Security Management (H2020-DS-2015-1, 2015)
Start date: 2016-09-01
End date: 2019-02-28
Duration (months): 30.0
Total project cost (EUR): 4552060.69
EU funding (EUR): 3607245.0
Participants: 13
Project status: CLOSED

Nowadays, cybercrime is one of the most relevant and critical threats to both the economy and society in Europe. Establishing efficient and effective ways to protect services and infrastructures from ever-evolving cyber threats is crucial for sustaining business integrity and reputation as well as protecting personal and sensitive data. To that end, the SHIELD project proposes a universal solution for dynamically establishing and deploying virtual security infrastructures into ISP and corporate networks. SHIELD builds on the huge momentum of Network Functions Virtualisation (NFV), as currently standardised by ETSI, in order to virtualise security appliances into virtual Network Security Functions (vNSFs), to be instantiated within the network infrastructure using NFV technologies and concepts, effectively monitoring and filtering network traffic in a distributed manner. Logs and metrics from vNSFs are aggregated into an information-driven Data Analysis and Remediation Engine (DARE), which leverages state-of-the-art big data storage and analytics in order to predict specific vulnerabilities and attacks by analysing the network and understanding the adversary possibilities, behaviour and intent. The SHIELD virtual security infrastructure can either used by the ISP internally for network monitoring and protection, but it can also be offered as-a-service to ISP customers; for this purpose, SHIELD establishes a “vNSF Store”, i.e. a repository of available virtual security functions (firewalls, DPIs, content filters etc.) from which the ISP customers can select the ones which best match their needs and deploy them to protect their infrastructure. This approach promotes openness and interoperability of security functions and offers an affordable, zero-CAPEX security solution for citizens and SMEs. Moreover, SHIELD services can be easily scaled up or down, configured and upgraded according to customers’ needs, as opposed to security solutions based on monolithic hardware.

Keywords: cybersecurity,virtual security functions,big data analytics
Crosslocations in the Mediterranean: rethinking the socio-cultural dynamics of relative positioning (CROSSLOCATIONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2433233.75
EU funding (EUR): 2433233.75
Participants: 1
Project status: CLOSED

The Mediterranean, a key socio-cultural, economic and political crossroads, has shifted its relative position recently, with profound effects for relations between the peoples associated with its diverse parts. Crosslocations is a groundbreaking theoretical approach that goes beyond current borders research to analyse the significance of the changes in relations between places and peoples that this involves. It does this through explaining shifts in the relative positioning of the Mediterranean’s many locations – i.e. the changing values of where people are rather than who they are. Approaches focusing on people’s identities, statecraft or networks do not provide a way to research how the relative value of ‘being somewhere in particular’ is changing and diversifying. The approach builds on the idea that in socio-cultural terms, location is a form of political, social, economic, and technical relative positioning, involving diverse scales that calibrate relative values (here called ‘locating regimes’). This means locations are both multiple and historically variable, so different types of location may overlap in the same geographical space, particularly in crossroads regions such as the Mediterranean. The dynamics between them alter relations between places, significantly affecting people’s daily lives, including their life chances, wellbeing, environmental, social and political conditions and status. The project will first research the locating regimes crossing the Mediterranean region (border regimes, infrastructures; digital technologies; fiscal, financial and trading systems; environmental policies; and social and religious structures); then intensively ethnographically study the socio-cultural dynamics of relative positioning that these regimes generate in selected parts of the Mediterranean region. Through explaining the dynamics of relative location, Crosslocations will transform our understanding of trans-local, socio-cultural relations and separations.

Keywords: relative location,socio cultural place,socio cultural space,border dynamics,borderlands,contemporary mediterranean
PROMOTING MENTAL WELLBEING IN THE AGEING URBAN POPULATION: DETERMINANTS, POLICIES AND INTERVENTIONS IN EUROPEAN CITIES (MINDMAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Norway,Finland,France,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,Canada
Call: Promoting mental wellbeing in the ageing population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2020-06-30
Duration (months): 54.0
Total project cost (EUR): 5743160.0
EU funding (EUR): 5743160.0
Participants: 15
Project status: CLOSED

Major depressive disorder, dementia, anxiety disorders, and substance abuse affect a substantial part of the European older population. Over 70% of Europeans reside in cities, and this percentage will increase in the next decades. Urbanization and ageing have enormous implications for public mental health. Cities pose major challenges for older citizens, but also offer opportunities for the design of policies, clinical and public health interventions that promote mental health. The overall aim of the MINDMAP project is to identify the opportunities offered by the urban environment for the promotion of mental wellbeing and cognitive function of older individuals in Europe. The project will advance understanding by bringing together longitudinal studies across cities in Europe, the US and Canada to unravel the causal pathways and multi-level interactions between the urban environment and the social, behavioural, psychosocial and biological determinants of mental health and cognitive function in older adults. Specifically, the project will (a) assess the impact of the urban environment on the mental wellbeing and disorders associated with ageing, and estimate the extent to which exposure to specific urban environmental factors and policies explain differences in ageing-related mental and cognitive disorders both within as well as between European cities, (b) assess the causal pathways and interactions between the urban environment and the individual determinants of mental health and cognitive ageing in older adults, (c) use agent-based modelling to simulate the effect of urban environmental, prevention and care policies on the trajectories of mental health and cognitive ageing across cities in Europe. Knowledge will significantly contribute to future-proof preventive strategies in urban settings favouring the mental dimension of healthy ageing, the reduction of the negative impact of mental disorders on co-morbidities, and maintaining cognitive ability in old age.

Keywords: city,mental health,prospective,ageing
Smart Synchronous inverter for grid’s stability (SYNCHRONVERTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany,Germany,Israel
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 2670652.0
EU funding (EUR): 1869456.4
Participants: 3
Project status: CLOSED

One of the key areas when it comes to Smart Grids is the safe integration of Renewable Energy Sources (RES) and Distributed Energy Storage systems (DES) onto the electric network. Nowadays RESs (solar, wind, etc.) and DES systems are connected to the grid via DC/AC converters (inverters). Currently these inverters do not provide the ancillary services required to avoid grid fluctuations derived from a growing share of RESs connected to the grid. Inverters playing an active role in grid stabilisation can efficiently mitigate some of the drawback that RESs have from an electric grid operator point of view such as transient grid-voltage fluctuations or frequency deviations. Synvertec, an Israeli company seed-funded by Horizon Green Tech Ventures (an investment alliance formed by Alstom S.A., Rotem Industries Ltd. and Gefen Investments) has developed and patented the Synchronverter, a system which connected to a standard inverter mimics the operation of a synchronous generator. Synchronverter integrates with existing inverters und turns them in effect into a virtual synchronous generator device being able to (i) actively respond to frequency changes and stabilize the voltage and (ii) imitate the inherent mechanical inertia of synchronous generators. The inverter market for renewable energy accounted in 2014 for more than €8.68 billion and is expected to exceed the €13.5 billion in 2017. Europe is the largest contributor with a 60% of the market and a revenue of €5.2 billion in 2014. The European market segment below 100 kW accounts for 85% of the total. Synvertec has founded a consortium with two German companies (an inverter manufacturer: Solutronic Energy, and an inverter supplier: Q3 Energie) to integrate their solution into commercial inverters and boost the deployment of the final solution into the market thanks to the well-stablished sales channels of those partners.

Keywords: renewable energy,distributed energy generation,smart grid,synchronous generator,electrical grid stability,inverter