Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A federated paradigm of real-world data sources utilization for the empowerment of diagnosis, prognosis and risk assessment of cardiovascular conditions (CVDLINK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Romania,Spain,Finland,Greece,Ireland,Germany,Moldova, Republic of,Lithuania,Estonia,Austria,Israel
Call: Better integration and use of health-related real-world and research data, including genomics, for improved clinical outcomes (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 9673490.0
EU funding (EUR): 9673490.0
Participants: 19
Project status: SIGNED

In the EU more than 6 million new cardiovascular disease (CVD) cases are reported yearly, along with 1.8 million related deaths, posing a substantial burden on the national healthcare systems and society in general. Development of effective preventive interventions, adopted for each individual and population, will not only reduce the overall cost of patient management, but will also justify the assertion that CVDs could be ultimately prevented and controlled. The exploration of existing clinical, genetic and real-world data sources can contribute to this direction, however several challenges related to the data availability, management and processing remain open. The 48-month project CVDLINK aims to tackle these challenges by implementing a privacy-by-design European-wide federated platform-as-a-service (PaaS) for the delivery of effective data-driven human-centric interventions and the advancement of research and management in the CVD domain. CVDLINK is based on two major offerings: (1) the seamless and legally compliant linking and integration, secure sharing and automated curation of existing data; and (2) a set of AI and data-enabled precision medicine tools and pipelines, for better diagnosis, risk stratification and treatment. In the context of the project, 7 different cardiovascular conditions will be examined, making use of different retrospective datasets, cohort studies and biobanks from 7 counties, aiming to set a paradigm of the how heterogeneous data sources, can be effectively exploited for building comprehensive AI-driven tools, in order to bring substantial benefits for health systems, patients, industry and EU citizens. The developed tools will be prospectively validated in 5 countries, demonstrating the impact of CVDLINK. Additionally, a set of best practices will be generated, which along with a cost-effectiveness analysis, and systematic raising awareness campaigns will promote its wide adoption in the mid-term.

Keywords: privacy by design,european wide federated platform as a service,effective data driven interventions,cvd,ai tools and pipelines,secure sharing and automated curation of data sources
Social Relations and the State in Renaissance Germany: Feud and the Law in the Prince-bishopric of Würzburg, 1500-1600 (SOCRESTA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-12-31
Duration (months): 27.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

SOCRESTA is the first systematic exploration of how ordinary people used violence and the law to resolve their disputes in Renaissance Germany after the 1495 ban on feud or Fehde in the Holy Roman Empire. To ensure its feasibility, the project focuses on the Prince-bishopric of Würzburg in 1500-1600. A central German territory, marked by the social upheaval of the Peasants’ War, religious discord of the Reformation and Counter-Reformation, and aristocratic conflicts, it presents an ideal laboratory for analysing early modern social relations and the state. SOCRESTA’s objective is to qualitatively and quantitatively investigate how early modern peasants, burghers and lesser nobles characterised, experienced and settled their disputes; how they used violence and the law to pursue their enmities; how interpersonal violence was shaped by gender and class expectations; how effective was the state in mediating disputes and controlling violence. SOCRESTA adopts a multidisciplinary approach rooted in legal anthropology and comparative social, legal, gender and women’s history and history of emotions to fill significant gaps in the history of feud in early modern Germany. By centring on the lower orders who remain critically underexplored, the innovative project goes well beyond normative discourses and legislation to address actual social phenomena and deconstruct the dominant views on Fehde as a medieval institution and prerogative of the nobility. Thereby, the project also contributes to a broader history of European social relations, the state, violence and the law. Finally, SOCRESTA’s programme enables the fellow to expand his existing knowledge in the field of history and acquire new techniques, especially in digital humanities, substantially advances his networking and dissemination skills, and enhances his teaching.

Keywords: holy roman empire,germany,feud,enmity,dispute settlement,violence,mediation,law,litigation,peacemaking,the state,emotions,class,gender
RESILIENT SUPPLY CHAINS FOR EUROPE (ResC4EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: Germany,Latvia,Spain,Poland,Ireland,Norway,Austria
Call: Boosting generation and diffusion of advanced technologies in SMEs based on a supply chain model (CSA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3336512.76
EU funding (EUR): 2977905.07
Participants: 10
Project status: SIGNED

The ResC4EU CSA is organized around 4 key objectives: (1) defining risk, disruption and alerts models for the supply chains of 14 “at risk” industrial ecosystems; (2) developing a holistic European value network for strengthening supply chains fostered by industrial clusters and strategic alliances; (3) accelerating the adoption of advanced methods and technologies for sustainability and resilience, through the use of a dedicated digital B2B platform, thereby benefitting from platform based growth models through network effects; and (4) demonstrating supply chain resilience of industrial ecosystems while also achieving climate neutrality and sustainability of economic processes. The consortium consists of 6 industrial clusters that have immediate access to over 1000 SMEs. Two research institutes cover logistics, supply chain risk modelling and product life-cycle analysis, respectively. Two SMEs, one orchestrating the outreach activities of the project and the other providing an open source, multisided, B2B supply chain platform derived from a Horizon 2020 project, complete the team. The workplan is designed to first activate the SMEs in the 6 clusters and then engage them in three ways: (a) to foster knowledge transfer early on, between the more technology-aware SMEs and those interested in innovating their processes; (b) to develop an actionable model for supply chain analysis that can be supported by the platform and will lead to immediate supply chain risk mitigation and resilience; and (c) to create impact by fostering new pan-European as well as cross-regional collaboration using a mix of strategically planned physical meetings and large-scale virtual community-building activities, among them “ResC4EU Net-Zero Industry Academies”. The cluster organizations cover logistics and supply chains of GHG-heavy industry, wood and furniture, advanced IT and have – in sum – outreach into all 14 industrial ecosystems, for which Pilot initiatives will be launched.

Keywords: supply chain,resilience,industrial ecosystem,cluster facilitated sme innovation support,digital multi sided platform,b2b,net zero,csa
Fast plasma-assisted perovskite crystallization for high efficiency lead-free perovskite thin film photovoltaics (SMARTLINE-PV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,France,Hungary,Czechia,Slovakia
Call: Novel Thin Film (TF) technologies targeting high efficiencies (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 4994686.25
EU funding (EUR): 4994686.25
Participants: 13
Project status: SIGNED

Metal halide perovskite solar cells have moved into the focus of energy materials research through impressive power conversion efficiencies. However, the most efficient perovskite absorbers contain toxic lead. Tin halide perovskites have emerged as a highly promising alternative and efficiencies up to 14.6% have been already reported, but to become a highly efficient thin film technology, further increasing their efficiency and stability, as well as fast and homogeneous large area perovskite crystallization compatible with roll-to-roll processes are still major hurdles. These challenges are tackled within SMARTLINE-PV by the development of a fast, robust and scalable plasma assisted crystallization technology leading to high quality tin perovskite films. The benefits lie in the high speed of the process, the low temperatures involved and in the precise control of perovskite nucleation and growth by a combination of the precursor chemistry and the plasma conditions. Moreover, (i) tailored interlayers will be applied to further improve the solar cell efficiency and stability and (ii) novel device concepts to fabricate flexible tin perovskite solar cell modules with selectable colour will be implemented. The lead-free thin film PV technology developed in SMARTLINE-PV will achieve efficiencies of 25%, with significant reduction of energy consumption and manufacturing costs compared to other thin film technologies, which typically involve high temperature steps. For the SMARTLINE-PV consortium, these advancements will lead to a plethora of new opportunities to strengthen the European photovoltaics industry in many sectors including the important building-integrated (BI) PV market. Ecodesign, circularity and social acceptance will play important roles in the whole development process in which a TRL progression of tin perovskite solar cells to TRL 5 is foreseen, which will be validated by the fabrication of BIPV-demonstrators and their operation in real-life conditions.

Keywords: tin perovskite,roll to roll fabrication,bipv,colored solar cell module,ecodesign
Ruthenium-containing Polymers against Ovarian Cancers (RuCoPOC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Nearly 250,000 women are diagnosed each year with ovarian cancer around the world, resulting in 140,000 deaths. High-grade epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer, ranking fifth overall in cancer deaths. The majority of women have widespread intra-abdominal disease at the time of diagnosis, and the 5-year survival rate for these women is only about 40% after receiving standard therapy. Currently, the standard first-line treatment for ovarian cancer consists of surgical cytoreduction and platinum-based chemotherapy. Although this approach has proven to be the most effective treatment to date, many ovarian cancers exhibit primary platinum resistance, and most patients develop secondary platinum resistance during the course of their disease. There is therefore a paucity of approved targeted therapies. Accordingly, effective novel therapies are needed to improve survival rates for patients diagnosed with ovarian cancer, especially in its advanced stages and in the setting of platinum resistance. The phenomenal success of cisplatin, oxaliplatin and carboplatin has boosted the research directed at novel metal-based anticancer drugs. My group has embarked a few years ago into a program to thoroughly investigate Ru compounds as anticancer drug candidates. However, one serious problem of metal-based drugs is often their intrinsic toxicity. To tackle this issue and circumvent these limitations, macromolecular delivery systems can be used to improve the potential of the respective anticancer ruthenium complexes. During the frame of the ERC consolidator grant PhotoMetMed, my group could demonstrate that an innovative drug-initiated polymerization methodology could be used to tackle this problem. In this proposal, to further demonstrate that this technology could be used on human, the in vivo efficacy of this system will be validated in several in ovarian cancer Patient-Derived Xenografts (PDXs) models.
Computational studies of new Dzyaloshinsky-Moriya interactions (New-DMI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

The magnetic phases that can be formed in chiral magnets has been of increasing interest due to the unique and exciting physics and potential applications these materials have. The chiral magnetism in these materials is created by the competition of energy terms in the Hamiltonian, namely exchange and the Dzyaloshinsky-Moriya Interaction (DMI). This DMI is created from the asymmetric environment of interacting magnetic spins and is thus connected with non-centrosymmetric crystallographic point groups. As these non-centrosymmetric point groups have different symmetries the form of the DMI equation changes from one to the next. However, only a small number of DMI point groups have been studied so far. This project will investigate the physics of the yet unexplored DMI terms computationally. These terms will be integrated into micromagnetic calculators and will be made open-source to enable the magnetism community to use it for research outside of this project. The multidimensional parameter space of these new DMI terms will be systematically investigated for new magnetic structures using machine learning techniques. Novel magnetic structures discovered will have their stability, equilibrium and non-equilibrium dynamics studied to gain new physics insights. This will lead to exciting new physical phenomena being discovered which may have the potential for applications in spintronics.

Keywords: skyrmions,topological magnetic structures,oommf,ubermag,open science
Social Aspects of the Green Transition (SoGreen) (SoGreen)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Bulgaria,Poland,Greece,Sweden,Slovenia,Netherlands,Italy,Portugal,United Kingdom,Croatia,Ireland,Norway,Austria,Belgium,Czechia,Finland,France,Iceland,Hungary
Call: Development of tools, solutions, modules to enable R&I on the social aspects of the green transition (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4999075.0
EU funding (EUR): 4999075.0
Participants: 33
Project status: SIGNED

The goal of the SoGreen project is to enhance the capacities of the four leading social science infrastructures in Europe ESS ERIC, SHARE ERIC, GGP and GUIDE, and generate valuable insights aimed at facilitating the study and evaluation of the social aspects of the green transition for different generations and socioeconomic groups across Europe, using a life-course perspective. SoGreen will contribute to the work programme topic “Next generation of scientific instrumentation, tools and methods and advanced digital solutions” by developing new services, comprising innovative tools, solutions, and questionnaire modules related to the social aspects of the green transition. The unique longitudinal and multi-generational perspective of the infrastructures involved goes beyond the state of the art by integrating new data and novel analytical frameworks to foster interdisciplinary insights on the green transition at national and regional levels, including new services, including geospatial data linkable with survey datasets and new visualisation tools. Central to our approach is the collaborative development of a new tool, the Green Transition Questionnaire Module, to ensure coherence in addressing environmental themes which will then be fielded within the different surveys. Moreover, we will also prepare harmonised aggregates of collected data and their visualization through a joint dissemination platform, enhancing accessibility and promoting consistency in data interpretation across various studies. The Knowledge Mobilisation Lab will be another new and innovative tool to identify, build, and engage a multifaceted network of different audiences and stakeholders. This includes professionals from policy, research, non-profit, and private sectors, thus actively shaping the discourse and informing developments related to the green transition.

Keywords: green transition,social surveys,share,ess,ggp,guide
Photo-assisted Light Alkanes Dehydrogenation to Olefines Under Mild Conditions with Trimetallic clusters Confined in Zr-based MOFs as the Catalyst (Photo2Olef)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Light olefins have been considered fundamental feedstocks in the chemical industry for decades. Current industrial processes for the synthesis of light olefins include naphtha cracking and light alkane dehydrogenation in thermochemical processes are under harsh conditions, and therefore energy-intensive. In the last decade, the solar-to-chemicals conversion process has attracted great attention, as it is deemed that the utilization of solar energy for the replacement of traditional fossil fuels is an ideal solution to the energy crisis and global warming. However, even though several reaction processes have been extensively studied and progress has been achieved, such as photocatalytic water splitting and photothermal/photocatalytic CO2 reduction, light-assisted alkane dehydrogenation reactions for the sustainable production of alkenes has not been explored yet. The objective of this research proposal is twofold: 1) developing new catalyst based on trimetallic clusters confined in Zr-based MOFs (TMC-MOF) for the photo-assisted light alkane dehydrogenation under mild conditions (<150oC), and 2) understanding the mechanism of the photo-assisted process, providing principles for design more efficient catalysts. The present project represents a significant step forward by showing the applicability of the solar-assisted alkane dehydrogenation process, presenting a significant advantage in terms of CO2-footprint.

Keywords: photo assisted catalysis,alkane,dehydrogenation,olefine,trimetallic cluster,mof,mild temperature
Evolutionary robustness of cell polarity during molecular diversification. (PolarRobustness)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Cells are often viewed as intricate machines, in which specific proteins work together in a tightly coordinated fashion to give rise to cellular functions. Surprisingly however, some proteins that are essential for core cellular functions in one species are absent in closely related species, while the core function itself is maintained. How this robustness is achieved, while the underlying molecular networks dramatically diversify during evolution is currently not understood. As a post-doc I showed that the polarity network in yeast can evolutionarily adapt to the loss of an important protein by losing three more proteins. My lab showed that these losses repair polarity through a collective adaptive response, affecting many cellular processes rather than only a few proteins. How do intricate cellular networks collectively achieve such evolutionary robustness? We will address this question with a library of experimentally evolved polarity networks in budding yeast to (1) investigate how general a collective adaptive response is, (2) examine which spatiotemporal aspects of polarity establishment are evolutionary robust, (3) determine how changes in (i) protein copy-numbers, (ii) post-translational modifications (PTMs), and (iii) buffering by self-organization, contribute to evolutionary robustness, and (4) dissect the molecular mechanisms. We will use transposon sequencing to identify the cellular processes involved, live cell microscopy to compare the robustness of various aspects of polarity, and mass spectrometry to compare changes in gene expression, PTMs and interaction partners. We will use multiscale simulations, rooted in statistical physics and constrained by our experimental results, to dissect how molecular changes propagate through the polarity network to achieve evolutionary robustness. Our approach will go beyond yeast polarity, because it can be applied to any functional protein network to deepen our understanding of how life works and evolves.

Keywords: cell polarity evolutionary robustness