Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transnational Book Diplomacy beyond the Cultural Cold War: Towards a Socio-Cultural History of the Tamizdat (TAMIZDAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

The transnational production, circulation and reception of Soviet and East European literature in the West during the Cold War challenges the dominant two-bloc narrative and tells us a different story about the cross-border flow of knowledge and ideas. Focusing on the intense cultural exchanges of the time across and beyond the ‘Nylon Curtain’ –an ideological and geopolitical border extremely permeable to cultural objects– this research project aims to challenge: 1) the traditional representation of Western and Eastern cultures as divided into two isolated blocs and 2) the representation of tamizdat as a mere ideological weapon of the ‘Cultural Cold War’. The term TAMIZDAT (‘published abroad’) refers to Soviet and Eastern European texts, unpublished in the Eastern bloc and clandestinely smuggled and published in the West. As an alternative transnational publishing practice with a specific socio-cultural value, tamizdat highlights «cooperation across apparent ideological division and cross-border interaction instead of hostility» (Mikkonen, Scott-Smith et al. 2019). The «emphasis on smaller national and transnational actors instead of governments» (ibidem) demonstrates the crucial role of book diplomacy in preventing the cultural isolation of the two blocs. Following O. Sanchez-Sibony, who questiones from a socio-economic perspective the representation of the Cold War as a bipolar contest between superpowers (2014), I will address the socio-cultural dimension of this narrative. Treating tamizdat as the result of socially and culturally regulated activities, I will consider the agency of social (activists of social movements, dissidents, Soviet and East European émigrés, diplomats etc.) and cultural actors (writers, editors, translators, literary agents, critics, journalists, etc.) who contributed to its transnational production, circulation and reception, in order to outline a comparative socio-cultural history of the Cold War.

Keywords: cultural cold war,transnational book diplomacy,agency of socio cultural actors,soviet and east european literature,tamizdat,dissent
Electrified Single Stage Ammonia Cracking to Compressed Hydrogen (SINGLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Spain,Slovenia,Italy
Call: Ammonia to Green Hydrogen: efficient system for ammonia cracking for application to long distance transportations (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 2989671.25
EU funding (EUR): 2989671.25
Participants: 7
Project status: SIGNED

SINGLE will enable ammonia as an energy carrier in the hydrogen value chain through demonstration of a proton ceramic electrochemical reactor (PCER) that integrates the ammonia dehydrogenation (ADH) reaction, hydrogen separation, heat management and compression in a single stage. The realization of 4 process steps in a single reactor allows the technology to achieve unprecedented energy efficiencies with a project target to demonstrate > 90% (HHV) at system level. The PCER-ADH technology enables to directly deliver purified, pressurized H2 (20 bar). SINGLE will demonstrate the technology at a 10 kg H2 /day scale that will provide a pathway for future scale-up systems ranging from small (fuelling stations) to large centralized (at harbour) deployments. A key technology component is the electrochemical cell, that will be engineered to act as a durable PGM-free ADH catalyst at 500 °C and a voltage-driven membrane separator. The achievements in SINGLE will be an important proof of technological feasibility advancing the technology from TRL3 to TRL5. To strengthen the implementation of NH3 as a H2 carrier, SINGLE will actively disseminate and communicate the results to influence stakeholders in the value chain, including standardization entities within the hydrogen sector. The consortium counts on partners from the industry, institute and academia sector with high world-wide excellence in the respective fields of catalysis, electrochemical membrane reactors, life-cycle assessment, process engineering, control systems and hydrogen fuelling stations.

Keywords: proton conducting ceramic,ammonia cracking,pressurized hydrogen,single stage
DESIGNing the European Partnership on One Health AMR (DESIGN OH AMR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Coordination and support actions
Countries involved: Sweden,France,Netherlands,Israel,Germany,Italy,Lithuania,Spain,United Kingdom,Belgium,Denmark
Call: A roadmap towards the creation of the European partnership on One Health antimicrobial resistance (OH AMR) (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-05-01
End date: 2024-09-30
Duration (months): 29.0
Total project cost (EUR): 990433.75
EU funding (EUR): 990432.0
Participants: 13
Project status: CLOSED

At the highest political levels antimicrobial resistance (AMR) is recognised as major threat to the health of citizens and societies, food security and development as it threatens the effective prevention and treatment of infections and thus the attainment of the Sustainable Development Goals. Global cooperation to address AMR with a one health approach is needed to tackle increasing levels of AMR in bacteria, fungi, viruses and parasites, which present a major threat to human, animal, plant and environmental health. DESIGN OH AMR aims to promote a one health response to link the multisectoral AMR research and innovation landscape. The DESIGN OH AMR will lay the preparatory groundwork of the candidate European co-funded partnership on OH AMR by addressing the ?European One Health Action Plan against AMR?. It will develop the strategic basis for the OH AMR partnership through engaging with, and building on, networks of research funders, policy makers, relevant agencies, European partnerships under the Horizon 2020 Framework Programme, and authorities to strengthen coordination and collaboration among different fields of research and innovation with relevance to AMR.

Keywords: antimicrobial resistance,one health
Elucidation of the biosynthesis pathway of the glaucoma drug pilocarpine in Pilocarpus plants (PiloSyn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Pilocarpine is a plant-derived alkaloid used to treat primary angle closure glaucoma and dry mouth. To meet the commercial demand for pilocarpine, the alkaloid is extracted from wild Pilocarpus plants in the Amazon rainforest. Excessive harvesting of wild populations has led to the official listing of several Pilocarpus species as threatened. Synthetic biology offers a sustainable approach for pilocarpine production. However, to produce the compound in heterologous hosts such as yeast, the biosynthesis pathway of pilocarpine needs to be elucidated first. In PiloSyn, I aim to unravel the natural biosynthesis pathway of pilocarpine, which is currently completely unknown. My host group recently obtained transcriptomics and metabolomics data sets of two Pilocarpus species, and these will serve as the basis of the project. As several pathway options are conceivable for pilocarpine biosynthesis, I will first reduce the number of options by identifying the metabolic precursors of the pathway and by obtaining structural and spatial information about possible pathway intermediates. Then, using the transcriptomics data sets, I will identify the enzymes that catalyze each of the pathway reactions. For this, I will use a learning-by-constructing approach in transiently transformed leaves of Nicotiana benthamiana. The results of PiloSyn can be used to establish a cheap and sustainable pilocarpine source in a heterologous host. This will eliminate the need to harvest wild Pilocarpus plants, thus is preventing their extinction and protecting the fragile ecosystem of the Amazon rainforest. Through PiloSyn, I will expand my knowledge on enzyme discovery and pathway elucidation and receive valuable training to become an independent and mature researcher in plant metabolism.

Keywords: plant metabolite biosynthesis pathway elucidation,pathway reconstruction
Challenging AI with Challenges from Physics: How to solve fundamental problems in Physics by AI and vice versa (AIPHY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,France,Denmark,Portugal,Ireland,Italy,Switzerland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 1907128.8
EU funding (EUR): 1907128.8
Participants: 10
Project status: SIGNED

AI is a disruptive technology that is currently changing not only many research fields but also substantially challenges current business concepts. Keeping up with the ever-faster progress on one hand side and the ever increasing competition from US and Chinese IT giants is a challenge for European Industry and Research Institutions. Yet, new concepts are required to keep pace. This concept is to intertwine modern AI concepts with strategies from the application field, a strategy where we claim that we can contribute substantially to a novel and promising research field. Particle physics is a formidable basis for such developments as there are no critical, personal data, data can be easily generated; and we have a good understanding of the underlying models and the ground truth. Yet, particle physics has challenges such as detailed questions of new physics and extremely high precision of the results. We identified three main fields where this project will contribute by solving 1) highly ill-posed inverse problems using physics models, 2) handling uncertainties, rare events and give reliable error bounds, and finally, 3) to be able to give explanations of the machine learning results in terms of physics ontologies and models. This highly challenging research agenda is tackled by 9 internationally recognized and leading researchers from both physics and computer science, from 5 universities in 5 European countries, all being member of the 4EU+ Alliance of European Universities. Over 4EU+ an excellent infrastructure for unique training opportunities is available to enable the research fellows to reach the ambitious goals, on one hand side and to educate them in critical and innovative thinking, management and social skills to prepare them optimally for leading positions in academics and industry.

Keywords: machine learning,inverse problems,physics informed neural networks,uncertainty quantification,explainable ai
DNA Microfactory for Autonomous Archiving (DNAMIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Lithuania,Switzerland,Germany,United Kingdom,Austria
Call: EIC Pathfinder Challenge: DNA-based digital data storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2437522.5
EU funding (EUR): 2437522.5
Participants: 8
Project status: SIGNED

We live in a society that produces and requires more and more data every year. It has become apparent that our current data storage strategies are not adequate to meet this increasing demand. The quest for robust, high-density, sustainable, and economically viable data storage solutions has highlighted the enormous potential and suitability of DNA data storage. However, to date, none of the solutions have considered a comprehensive vision of anchoring this technology in standardised archival frameworks that will support long-term storage. Besides, most DNA data storage applications are limited to specialist laboratories due to complex (and expensive) protocols. Our project entitled DNAMIC (DNA Microfactory for Autonomous Archiving) proposes an autonomous solution based around a low energy consumption microfactory that will be developed for end-to-end DNA data archiving(from encoding to decoding via synthesis, storage, quality control and sequencing among others). The microfactory is interoperable and future proof thanks to technology block that can be easily modified or replaced. Our solution will be compliant with the Open Archival Information System (OAIS) reference model (ISO 14721). To enable the implementation of disaster recovery strategies, critical for long term storage, we propose a novel dual-level encoding scheme. This approach allows the development of self-contained data that include easily changeable metadata, and unalterable data.

Keywords: dna data storage
Preclinical development of a nanomedicine candidate for Fabry rare disease treatment to enter clinical phase (Nano4Rare)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Spain
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2023-11-01
End date: 2026-04-30
Duration (months): 30.0
Total project cost (EUR): 2498563.75
EU funding (EUR): 2498563.75
Participants: 2
Project status: SIGNED

Despite the development of new orphan medicines in recent years, there are still limited treatment options available for rare diseases. Nano4Rare team has developed a patent protected nanoencapsulation KET for the development of cost-effective therapies for rare diseases, based on biomolecules. Nano4Rare team has successfully used this technology for the development of a new patent protected medicinal product candidate, named nanoGLA, for the treatment of Fabry disease, which is one of the most devasting LSD rare diseases. NanoGLA has been designated, on January 2021, as Orphan Drug by the European Medicine Agency (EMA) and the European Comission. With the EU H2020 Smart4Fabry, nanoGLA was brought to an advanced stage of preclinical development (first GLP-toxicology in rats included). Under Phoenix EU Project (#953110)(2021-2025), nano-GLA production will be scaled-up and brought to GMP conditions. As a first objective, Nano4Rare project will use nanoGLA engineered batches produced in the frame of Phoenix project to complete the preclinical phase and generate sufficient quality data on safety, efficacy, and quality in order to get approval by regulators to proceed with clinical phase. As a second objective, a new spin-off company will be created for the advancement of the nanoGLA towards the market and the commercialisation of the patent protected nanoencapsulation platform to generate new product candidates for rare disease treatments.

Keywords: nanomedicine,nanoencapsulation of biomolecules,rare disease,fabry disease,preclinical development,spin off creation,
Discovering Collagen I degradation process in chronic diseases with fibrotic component (DisCo-I)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,France,Greece,Germany
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2216320.2
EU funding (EUR): 1648915.2
Participants: 10
Project status: SIGNED

Fibrosis-related chronic diseases (CDs) are amongst the biggest societal burdens in Europe, with fibrosis being recognised as the main driver of morbidity and mortality. Extracellular matrix (ECM) is a key player in fibrosis, with an excessive accumulation of type I collagen (COL1) being a predominant component of the fibrotic tissue. While the increase in COL1 production is considered a main driver of fibrosis, respective drugs had limited efficacy. New evidence indicates that attenuation of COL1 degradation is highly relevant, contributing to onset and progression of fibrosis. Ambitious early stage researchers (ESRs) will join forces within a multi-disciplinary, comprehensive and inter-sectoral doctorate training programme, embedded in an existing network of excellent research groups across Europe, to investigate the “outside-the-box idea” on impaired COL1 degradation being a key driver of fibrosis. The main scientific goal is to improve the understanding of molecular mechanisms associated with COL1 degradation in major fibrosis-related CDs, and investigate the disruptive hypothesis of attenuated COL1 degradation being the key driver of fibrosis and a major contributor to onset and progression of CDs. This will be achieved through multi-disciplinary research and training combining state-of-the-art –omics approaches and data (peptidomics, proteomics and transcriptomics) in a bioinformatics framework, followed by in- and ex-vivo investigation, complemented with ESRs training on translational skills and competences. Such a programme will train a new generation of translational researchers able to covert ideas into products, and will have a profound impact on their employability, and competitiveness. The project will progress beyond the state of the art and provide the currently missing fundamental knowledge on the molecular pathophysiology of COL1 degradation, setting up the stage for novel biomarkers and anti-fibrotic therapies.

Keywords: collagen i,fibrosis,chronic diseases,disease pathophisiology,proteomics,peptidomics,transcriptomics,in vivo,ex vivo
Support and networks To Accelerate the construction and Renovation innovation track to market (STAR-track)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Coordination and support actions
Partnership: B4P (co-programmed)
Countries involved: France,Denmark,Greece,Slovenia,United Kingdom,Italy,Belgium,Luxembourg,Spain
Call: Fast-tracking and promoting built environment construction and renovation innovation with local value chains (Built4People Partnership) (HORIZON-CL5-2023-D4-02, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 1942919.99
EU funding (EUR): 1881205.7
Participants: 23
Project status: SIGNED

STAR*track aims at expanding the Built4People Innovation Cluster (B4PIC) network developed in the HE project NEBULA and strengthening and supporting B4PICs and their members to deliver sustainable and people-centric innovation and accelerate uptake by regional value and supply chains. This overarching objective will be achieved by: - Integrating new B4PICS: 6 new B4PICs will be set-up in regions so far not covered by the B4PIC network and receive direct support. Outreach activities to innovation clusters will be made in order to reach the B4P contractual target of 10-15 fully mature B4PICs by 2028. - Creating enabling conditions and providing tools and training for B4PICs and their members for increased development and market transfer of sustainable construction and renovation innovation. - Accelerating the demonstration of holistic and inclusive solutions with high market potential through tailored support mechanisms (incl. access to demo sites) - Facilitating access to funding for demonstration, scale-up and implementation of sustainable innovation by local/regional construction value chains - Paving the way for replication, wide-spread use of the supporting tools and services, and continuous expansion of the Built4People network based on a UE27 replication plan with a long-term vision and business model. In order to make B4PICs attractive for different target groups of the innovation value chain, concrete value propositions will be defined to highlight the impact of B4PIC with respect to improvement of innovation capacities and development of sustainable business opportunities. The impact of the B4PIC network and the B4PICs themselves will be measured to show their significance for the green, digital, and people-centric transition of the Built Environment sector, the up-skilling of innovation actors, and the acceleration of construction and renovation products and solutions towards climate neutrality, in line with the impacts laid out in the Work Programme.

Keywords: built4people innovation clusters,built4people innovation cluster network,innovation support,demonstration,end user participation,innovation value chains,digital tools,access to financing