Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Malleability in mediated ideals: A paradigm to understand effects of contemporary media in adolescents’ well-being (MIMIc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

MIMIc will develop and establish a new theoretical perspective that will fundamentally redirect the current research on idealised representations of life in mass and social media and their effects on (adolescent) audiences. MIMIc combines insights from cultural sociology, media theory, and developmental psychology to define the effects of ‘malleable ideals’ in media. Malleable ideals are idealised representations of different achievements and are characterised by the malleability that surrounds these achievements; they approach ideals from a utilitarian, individualistic discourse that links personal responsibility and dedication with both the failure and success of achievements. By focusing on malleable ideals and thus applying a sociocultural analysis to media ideals, a crucial perspective will be added to our understanding of the development of adolescents and, more precisely, the pressures they experience. These pressures are viewed as an important factor in the relatively high prevalence of both internalising and externalising problems in adolescence. Content analytical, diary, and longitudinal studies in three different cultural contexts will be triangulated to develop a theoretical model: MIME. Content analyses map the extent to which media abound with aesthetic, sexual, professional, romantic, and social ideals as well as the importance of malleability in these representations. Longitudinal and diary research examine the internalisation of these ideals as a key explanatory process for the effects they may have both on outcomes regarding personal and societal problems and among different groups of adolescents. The multimethod approach further allows the theorisation and testing of the role of varying time intervals associated with understanding the effects of mediated ideals. For this research, the applicant who is experienced in multimethod research on media effects among adolescents will compose and lead a cross-national team of researchers.

Keywords: media psychology,media effects,media ideals,adolescence,well being,communication theory,differential susceptibility
Supramolecular Polyamine Gene Vectors for Cancer Therapy (SUPRO-GEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Israel,Argentina,South Africa,Italy,Spain,Thailand,United States,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2026-02-28
Duration (months): 54.0
Total project cost (EUR): 989000.0
EU funding (EUR): 989000.0
Participants: 10
Project status: SIGNED

Gene therapy, most commonly using viral vectors, can be applied to inhibit or edit the expression of any gene of interest, being highly specific. However, there is an urgent need to find non-viral vectors with low toxicity and high transfection and targeting efficacies. The SUPRO-GEN project aims to design supramolecular vectors for gene delivery for applications in immunotherapy and cancer stem cell therapy. Peptide and glyco engineering of the vectors will result in high tumor targeting efficacy. Transfection and therapeutic efficacy will be tested in vitro and in vivo. Cell trafficking and biological fate of vectors will be studied by advanced imaging techniques. SUPRO-GEN is a concerted action based on multidisciplinary expertise in materials science, chemistry, genetic engineering, cancer biology, cancer therapy, and imaging. The project will bring together a talented consortium of academic groups and a high-tech SME from Spain, Italy, Israel, the United States, South Africa, Argentina and Thailand. Early Stage and Experienced researchers will receive training and conduct research in a hosting institution abroad. In addition to achieving the scientific goals, the project also aims to develop highly skilled professionals at the interface of materials science and engineering and the biological sciences.

Keywords: self assembly,polyamines,gene therapy,silencing rna,gene editing,targeting peptides,carbohydrates,cancer stem cells,biological fate
LEGEND, Sport goes viral (LEGEND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We are building an ecosystem of tools and apps to key agents of the sport sector. We see it as Google does with its platform. Their core is Search but then it provides with dozens of tools like Gmail, Calendar, Youtube or Analytics so user stay in their platform. Using sport as the soul of our platform we have started building this ecosystem. Currently, we have developed a tournament manager where league and championship organizers can manage them. We allow them to create as many tournaments as they need, create teams and assign them players. They can organize almost every league or championship that may come to your mind. With this tool, public (local government, Universities or Schools) and private (sport facilities, individuals, federations, associations, etc) managers from all around the world can send real time alerts, manage the classifications in an easy way, generate automatic calendars, publish the rules and news, define roles as referees or team managers and many more features to come. We have also developed mobile apps for following the league but also the users can organize their friendly matches, comment on them before and after the match, check the results of their friends and to share them in other social networks. Not only we ease the organization of the matches but we also motivate them to report the results by adding an algorithm to calculate their skill level of every sport. We have also added gamification technics to the app so users can get badges depending on their results. Finally, users can track and check all their stats and historical results. LEGEND project will help miLeyenda to create a feasibility plan for going international. Currently, we have acquired more than 120.000 users in 3 months and we are ready to go a step further.

Keywords: mobile,sports
New Hybrid Thermoplastic Composite Aerostructures manufactured by Out of Autoclave Continuous Automated Technologies (NHYTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Greece,Belgium,France,United Kingdom
Call: Reducing energy consumption and environmental impact of aviation (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-05-01
End date: 2020-10-31
Duration (months): 42.0
Total project cost (EUR): 5250356.25
EU funding (EUR): 5250356.25
Participants: 8
Project status: CLOSED

NHYTE project aims at developing and demonstrating concepts and methodologies enabling the realization of innovative integrated aero-structures, made of a new hybrid thermoplastic matrix composite material with multifunctional capabilities. The high-performing material proposed, based on a commercial PEEK-Carbon Fiber Prepreg with addition of amorphous (PEI) films, answers to the needs to have reduced weight and consequently reduced fuel consumptions and emissions on an aircraft, as well as reduced manufacturing and operational costs. Demonstration aero-structures will be fabricated by an innovative working cell implementing an advanced continuous automated production process, including: automated hybrid material fabrication; manufacturing of skin panels by automated fiber placement in-situ consolidation process; fabrication of stringers by continuous forming; component assembly by induction welding. The innovative material, conceived and patented by a partner of the Consortium, is an example of multifunctional composite, since it returns both functions of toughness improvement (multilayer material) and process simplification. This concept on one side will provide an advantage from the structural point of view, in terms of better impact damage performance; while on the other side major advantages will result on processing simplification, in particular including improved cycle times and lower energy consumptions, since it does not require the use of an autoclave curing phase. As of today, its usage has been limited to fabricate panels, only at laboratory level; hence, a suitable improvement finalized to process in industrial environment is needed. Proposed process techniques and assembly will be the first step towards the industrial application of the innovative material. Consortium has set a target for weight saving not less than 5% for primary structures. Further reduction of full life cycle cost is expected from scrape material and end of life structures recycling.

Keywords: in situ consolidation afp,automated technology,aircraft structure,thermoplastic composite
Enzyme-Degradable Polyion-Complex (PIC) Particles for the Treatment and Detection of Pseudomonas aeruginosa (AntibioPICs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-12
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Here, we will develop new enzyme-degradable polymers for the preparation of polyion complex (PIC) particles based of antimicrobial molecules with low charge densities. The main goals are: 1. Synthesis of enzyme-responsive polymers, with a) enough charge density to facilitate PIC particle formation, and b) degradable by Pseudolysin, a protease secreted by opportunistic bacteria Pseudomonas aeruginosa; 2. Preparation of Pseudolysin-Degradable PIC Particles, from these enzyme responsive polymers and 1) Polymyxin B (PolB), an antimicrobial peptide with only 5 cationic charges; or 2) FM® 1-43 Dye, a cationic membrane dye that stains gram-negative bacteria; 3. Characterisation of PIC particle stability and enzyme-degradation kinetics and selectivity, and 4. In-vitro evaluation of 1) the antimicrobial activity against P. aeruginosa of PolB-containing particles and 2) the ability of FM-containing particles to stain P. aeruginosa. Completion of these goals will allow us to demonstrate that: a) Polymers with high charge densities can be prepared based on short peptides; that b) stable PIC particles can be prepared from relevant small molecules; despite the challenges posed by their low charge density; that c) the stability and release profile of these biologically active molecules can be tuned as a function of polymer composition and particle formulation; and that d) PIC particles are promising vectors for the delivery of antimicrobial molecules. The main scientific challenge lies in the development of the proposed materials, but the molecules to be delivered have been selected because of their relevance to antimicrobial resistance, one of the research priorities of the European Commission. Each exemplar will contribute to address complementary problems: 1) the development of better methods to use currently available antibiotics (PolB) and 2) the early detection of pathogenic strains (FM).

Keywords: enzyme responsive,pic particles,antimicrobial delivery
Plasma cell heterogeneity and dynamics in patient tumors (PCinBC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-05-30
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing this work. This study’s results could help clarify fundamental questions regarding the biology of tumor-infiltrating plasma cells and help uncover novel anticancer therapeutic targets.

Keywords: tumor immunology,single cell genomics,spatial transcriptomics
Relational Symmetry in the Baboon: towards symbols and language (SymBa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Language and the symbolic use of labels underpin human cognition. As these features imply back and forths between label and labelled object, they require relational symmetry: the capacity to reverse a learned relation A->B into B->A. In non-human animals, such flexible encoding of bidirectional relations has been difficult to obtain experimentally, mostly due to their failure to reverse stimulus relations. This apparent absence of symmetry suggests an evolutionary gap at the origin of human language. Yet, a number of procedural biases, inlcuding perceptual ones, may account for this failure to demonstrate symmetry. Moreover, all studies have relied on specific motor outputs to reveal symmetry, whereas symmetric relations may simply not be learned in such an explicit form. Using the baboon as model primate species, and a worldwide unique, automatized, high-throughput behavioral platform as experimental system, we will conduct new experiments to re-assess this question. We will implement relational learning procedures which correct for all biases identified in past experiments, and rely on implicit rather than explicit measurements to test for the emergence of symmetry. Furthermore, we will study the effects of symmetry on stimulus networks, to assess the baboons’ abilities for flexible relational encoding when more stimuli are involved. A crucial feature of natural intelligence such as relational symnetry ought to be also considered in Artificial Intelligence (AI) systems, as their relational learning abilities are still limited. We will thus investigate the capacity of existing connectionnist models (e.g. Recurrent Neural Networks) to learn symmetrical associations of stimuli, and will explore new architectures able to implement symmetry. Both symmetry or its absence in baboons would inform about the fundaments of human cognition. Hence, far-reaching implications are expected from this project, which may open new avenues of research in both AI and psychology.

Keywords: relational symmetry,relational learning,equivalence classes,symbols,comparative psychology,animal experimentation,associative learning,language,artificial neural entworks,connectionnist model
Transnational Gangs as Agents of Mediation: Experiences of Conflict Resolution in Street Youth Organizations in Southern Europe, North Africa and the Americas (TRANSGANG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 2343249.0
EU funding (EUR): 2343249.0
Participants: 1
Project status: SIGNED

TRANSGANG aims to develop a renewed model for the analysis of transnational youth gangs in the global age, in dialogue with two classics of urban ethnography, published nearly a century ago: The Gang, by F.M. Thrasher (1926) and The Polish Peasant in Europe and America, by W. I. Thomas and F. Znaniecki (1918-1920). To do this, the project will start by a systematic review of the historical literature on youth gangs, which will try to overcome the north-american-centrism, dominant in contemporary criminology. The central phase of the research will focus on a multisited and multilevel ethnography that will explore experiences in which gangs have acted as agents of mediation, as well as the barriers that have blocked these attempts. The project will compare street youth organizations from two transnational communities -Latinos and Arabs-, both in their homelands and in their new European neigbourhoods. Starting with three case studies of “good practices” in Barcelona, Medellin and Casablanca, which will be studied in depth, contrasts with other cases in which other policies have been implemented will be established: Madrid, Marseille and Milan in southern Europe; Oran Tunis and Cairo in north Africa; Chicago, Santiago de Cuba and San Salvador in the Americas. Using an experimental approach based on the “extended case method”, it will have as its theme the making of a film that collects the experience of members or former members of gangs who have participated in mediation experiences. The ultimate goal is to develop a renewed transnational, inter-generational, intergeneric and transmedia approach to Twenty-First-century gangs, very different from the local, coeval, male and face-to-face model used for understanding gangs in the Twentieth century. Although the focus of the project is theoretical, its purpose is applied: to deduce more effective ways of intervention to prevent the hegemony of the criminal gang model that appears as dominant in the neoliberal era.

Keywords: youth,gangs,transnationalism
An end-to-end verification architecture for building Certified Implementations of Robust, Cryptographically Secure web applications (CIRCUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1885248.0
EU funding (EUR): 1885248.0
Participants: 1
Project status: CLOSED

The security of modern web applications depends on a variety of critical components including cryptographic libraries, Transport Layer Security (TLS), browser security mechanisms, and single sign-on protocols. Although these components are widely used, their security guarantees remain poorly understood, leading to subtle bugs and frequent attacks. Rather than fixing one attack at a time, we advocate the use of formal security verification to identify and eliminate entire classes of vulnerabilities in one go. With the aid of my ERC starting grant, I have built a team that has already achieved landmark results in this direction. We built the first TLS implementation with a cryptographic proof of security. We discovered high-profile vulnerabilities such as the recent Triple Handshake and FREAK attacks, both of which triggered critical security updates to all major web browsers and TLS libraries. So far, our security theorems only apply to carefully-written standalone reference implementations. CIRCUS proposes to take on the next great challenge: verifying the end-to-end security of web applications running in mainstream software. The key idea is to identify the core security components of web browsers and servers and replace them by rigorously verified components that offer the same functionality but with robust security guarantees. Our goal is ambitious and there are many challenges to overcome, but we believe this is an opportune time for this proposal. In response to the Snowden reports, many cryptographic libraries and protocols are currently being audited and redesigned. Standards bodies and software developers are inviting researchers to help analyse their designs and code. Responding to their call requires a team of researchers who are willing to deal with the messy details of nascent standards and legacy code, and at the same time prove strong security theorems based on precise cryptographic assumptions. We are able, we are willing, and the time is now.