Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the function and regulation of centriolar satellites: key regulators of the centrosome/cilium complex (CentSatRegFunc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Türkiye
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2023-05-31
Duration (months): 84.0
Total project cost (EUR): 1499818.75
EU funding (EUR): 1499818.75
Participants: 1
Project status: SIGNED

Centrosomes are the main microtubule-organizing centers of animal cells. They influence the morphology of the microtubule cytoskeleton and function as the base of primary cilium, a nexus for important signaling pathways. Structural and functional defects in centrosome/cilium complex cause a variety of human diseases including cancer, ciliopathies and microcephaly. To understand the relationship between human diseases and centrosome/cilium abnormalities, it is essential to elucidate the biogenesis of centrosome/cilium complex and the control mechanisms that regulate their structure and function. To tackle these fundamental problems, we will dissect the function and regulation of centriolar satellites, the array of granules that localize around the centrosome/cilium complex in mammalian cells. Only recently interest in the satellites has grown because mutations affecting satellite components were shown to cause ciliopathies, microcephaly and schizophrenia. Remarkably, many centrosome/cilium proteins localize to these structures and we lack understanding of when, why and how these proteins localize to satellites. The central hypothesis of this grant is that satellites ensure proper centrosome/cilium complex structure and function by acting as transit paths for modification, assembly, storage, stability and trafficking of centrosome/cilium proteins. In Aim 1, we will identify the nature of regulatory and molecular relationship between satellites and the centrosome/cilium complex. In Aim 2, we will elucidate the role of satellites in proteostasis of centrosome/cilium proteins. In Aim 3, we will investigate the functional significance of satellite-localization of centrosome/cilium proteins during processes that go awry in human disease. Using a multidisciplinary approach, the proposed research will expand our knowledge of the spatiotemporal regulation of the centrosome/cilium complex and provide new insights into pathogenesis of ciliopathies and primary microcephaly.

Keywords: centrosome,centriolar satellites,centriole,primary cilium,microtubule,ciliopathies,centriole duplication,ciliogenesis,cancer,primary microcephaly,proximity labeling,snap,bioid,apex
Droughts and Water Scarcity in the EU: Economic Impact, Adaptation, Policy Implications and Integrated Assessment Modelling (WATER DROP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy,Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-05-01
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 2
Project status: CLOSED

Drought risks and water scarcity are expected to intensify as a result of human-induced climate change. Some areas in Europe, notably the Mediterranean countries are more prone to prolonged drought spells than others. Understanding and properly measuring the overall and sector-wide economic impact of those episodes at the geographically most disaggregated level is of crucial importance for the design of disaster risk management instruments and other policy-related issues. At the same time, it becomes necessary to assess whether this response varies over time. In other words, we need to know whether we are somehow adapting to climate change. Adaptation in the context of climate change is a concept that raises many questions: empirical estimates are scarce and highly desired by scientists and institutions like the IPCC; how this adaptation mechanism can be embedded into economic models of climate change is also an unresolved issue. I will try to address both in this project. The objective of my research is twofold: on the one hand, obtain quantitative measures of the economic impact of droughts and test for the existence of adapting behaviour and, on the other hand, respond the demands of the IPCC that urge for progress in the integration and modelling of adaptation into climate-economy models. To do so, in a first stage I will apply econometric techniques envisaged by the new climate-economy literature to regional, European-wide data to obtain estimates of the economic consequences of droughts and unveil potential adapting behaviour. Then, I will resort to sophisticated climate-economy models, like CGE and IAM models, to shed light into the modelling of adapting behaviour under deterministic and stochastic scenarios.

Keywords: adaptation to climate change,dynamic programming under uncertainty
Vacuum Medical Device for Safe and Gentle Cervix Grasping Gynecological Applications (ASPIVIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For years, gynecologist practices related to Intra-Uterine Contraceptive Device (IUCD) insertions, curettage and several other common indications, have featured poor care and low attention to female patients. The use of the Tenaculum, grasping and pulling on the cervix, inside the vaginal cavity, proved to be painful and traumatic for 84% of the women, and eventually to trigger lesions and bleeding in 29% of the patients, as well as cross-contamination in 5-10% of the women. These disadvantages refrain the use of IUCD contraceptive which exacerbates the unintended pregnancies, sized yearly in 85 mills and representing billions of euros in social costs worldwide. In response, we have developed Aspivix, a new disruptive gynecological device that reduces the pain and eradicates the bleeding during the exploration procedure. Our patented device will replace the Tenaculum forceps, unchanged for over 100 years, to provide gynecologists an easy-to-use device where gentle and firm cervix uterus grasping and traction is needed. Thus, our device will facilitate the adoption of IUCD, which could avoid up to 8% of unintended pregnancies and reduce derived social costs. Besides, Aspivix is intended for a single use which prevents the risk of contamination and cross-infection. Overall, Aspivix has the potential to shorten the intervention procedure (2 steps instead 7), which will represent for the physician a 28% economic benefit. As result, Aspivix will fulfill the needs of more than 64 M of women worldwide/year, a market that is projected to grow at a CAGR2016-2021 of ~6.5% due to the high demand of IUCD insertions and is valued in more than €350M. In this way, thanks to the sales of 22M units in the European, Asian and North American Markets after 5-years, Aspivix will generate cumulative revenues of nearly €80 M and, considering the total investment of €3.6M, a return of investment (ROI) of €8.3 per euro invested.

Keywords: medical device,unintended pregnancies control,gynecologist practices,women empowering
Bricks manufacturing technologies to increase built heritage resilience and to raise common identities of peoples (CLAYONRISK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-15
End date: 2021-04-14
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

The CLAYONRISK project mainly aims to foster bricks manufacture processes in order to mitigate the negative impact of extreme weather events and earthquakes on historical structures. As a traditional building material widely used from ancient times and worldwide, both eco-innovative solutions and socio-cultural values of peoples will be tackled. For first time, the manufacturing of building bricks is addressed as a preventive measure for Disaster Risk Reduction management. Starting from: i) bricks decay due to climate change make ancient structures much more vulnerable to seismic risk, and ii) the negative impact of disasters on historical structures could be mitigated by improving the physical properties of bricks, directly influenced by the manufacturing parameters, a multidisciplinary and comparative study of bricks -both ancient and currently produced- is accomplished. Archaeometric methodologies by means of multianalytical approach is followed and building bricks resistance over time is assessed considering their mechanical behavior after ageing tests performance. Northern Italy entails an outstanding site to accomplish the project, as it is a high humidity area with regular seismic activity where the geology has enhanced an exceptional architecture shaped by bricks and a ceramic industry leadership. With a cutting-edge scope, CLAYONRISK will state bricks resistance over time and the achievement of technological improvements and sustainable solutions towards the strengthening of heritage (and new) constructions, ensuring peoples traditions and the socio-cultural values of ancient structures. The intersectorial transfer of knowledge fostered by CLAYONRISK will promote a protocol development, launched by the academy-industry cooperation and where bricks entail a transnational understanding resource to aware the European cultural identity. The project entails a broad range of opportunities for the candidate and will enlarge her research prospects in the future.

Keywords: disaster risk reduction management,preventive measures,bricks mechanical behavior,cost effective solutions,protocols development,traditional and cultural values
Satellite CV-QKD (SatCV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Quantum Key Distribution (QKD) allows two parties to exchange a cryptographic key in an unconditionally secure way. Thus, this system will be secure even after the development of a quantum computer, which is thought to efficiently break current key exchange mechanisms based on public-key cryptography. While most current QKD implementations are fiber-based, its intrinsic limitation to some hundred kilometers, due to fiber losses, makes satellite QKD a crucial technology for the establishment of a secure link at a world-wide scale. The research on satellite QKD has mainly focused on discrete variable (DV) protocols, which are less sensitive to channel transmission but require single photon detection technology. Continuous variable (CV) protocols, on the other hand, are based on standard telecom detection technology, which is much faster and more efficient. Recently, CV protocols have shown to work well in high losses fiber-based environments. This action aims to extend the CV scheme to the free-space domain, implementing a full, self-referenced CV-QKD scheme on a free-space channel, as a first step for a future satellite implementation of such technology.

Keywords: quantum key distribution,continuous variables,free space,satellite
Multi-Functional Detective System (MFDS) – Advanced, ‘Intelligent Transport System’ creating smarter and safer European roads (MFDS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wilhelm Schröder GmbH has developed the ‘Multi-Functional Detection System’ (MFDS), a highly versatile ‘Intelligent Transport System’ that will make EU roads better integrated, safer, intelligent and environmentally friendly. MFDS is a unique, affordable and unrestricted telematics technology with several functions: wrong-way driver detection, traffic congestion detection, vehicle counting by vehicle classification and parking accounting. The core innovation of the MFDS is its capability to complete all functions simultaneously in a single system that is low-cost to procure and install with low-power usage. An MFDS unit consists of a detection of 6 delineators (pillars) that distributes a secure radio field across the target path; objects within the field are passively detected and classified with 100% precision. Data obtained is immediately communicated to motorists via an LED lighting interface built into the delineators as well as being securely provided via cloud to the relevant officials via system interfaces to warn motorists in a wider perimeter with other means. With our initial target market in the EU, during Phase 1 and Phase 2 we plan to market to road operators in target countries with the intention to generate pre-sales that will enable our target volume sales once Phase 3 is reached in 2020. Once commercialised, we plan for 6,500+ unit sets to be deployed by 2024. The principle project objective is to enhance MFDS and demonstrate to the target market the efficiency and environmental improvements our technology offers over state-of-the-art alternatives. This Feasibility Study will allow us to complete a market study and use customer feedback to develop the project concept; identify strategic Phase 2 collaborators; scope the legislative pathway; plan the technical and commercial work to be completed during Phase 2 and produce a fully elaborated business plan to be used as the basis of a Phase 2 application.

Keywords: telematics system,traffic congestion detection,vehicle counting by classification,parking,accounting,wrong way driver detection,congestion detection,radio field detection,vehicle warning
A Human-centred Internet of Things Platform for the Sustainable Digital Mine of the Future (Dig_IT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Italy,Spain,Cyprus,Finland,Norway,Norway,Finland,Greece,Serbia,Belgium,Greece,United Kingdom,United Kingdom
Call: New solutions for the sustainable production of raw materials (H2020-SC5-2019-2, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 6997416.25
EU funding (EUR): 6997416.25
Participants: 21
Project status: SIGNED

The turnover of mining and quarrying in Europe reaches up to 224 billion Euros and has generated EUR 64.9 billion of value added, 1% of the non-financial business economy total. The rise of key enabling technologies and the urbanisation and industrialisation of emerging economies in combination with increase in population and living standards will continue to drive growing demand for raw materials. The need to extract raw materials in a profitable, environmentally sound, and safe way for both mining workforce and communities is driving the mining industry towards innovative approaches to transform operations. Even though Industry 4.0 offers a wide spectrum of solutions, and intelligent technologies to address respective challenges, the mining industry hesitates to adopt such innovative approaches when compared to downstream industries. In addition, the need for a human-centred, environmentally oriented and society-driven approach is emerging in developing Industrial Internet of Things technologies for mining. Dig_IT will address the needs of the mining industry to move forward towards a sustainable use of resources while keeping people and environment at the forefront of their priorities. In order to achieve that Dig_IT proposes the development of a smart Industrial Internet of Things platform (IIoTp) that will improve the efficiency and sustainability of mining operations by connecting cyber and physical systems. The platform will collect data from sensors at 3 levels: (i) human, (ii) assets, (iii) environment and will also incorporate both market real time and historical data. The impact of Dig_IT to the European Mining industry, but also the society itself, can be summarised in the following (with a horizon of 4 years after project ends): (i) increase of the mining efficiency by 17%, (ii) increased OEE for machines and loading by 20% and 18% respectively, (iii) 19% reduction of CO2eq, (iv) about 310 new jobs created and (v) over 28M EUR ROI for the consortium.

Keywords: sustainable production of raw materials,digital twin,blockchain,sustainability compliance labelling,smart scheduling,interactive dss,predictive maintenance,biometrics,ehs monitoring
High Performance Environmentally Benign Quantum Dot@Perovskite Hybrid Materials for Near-IR LED: Design, Photodynamic Behaviour to Device Fabrication (LED4Nature)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-03
End date: 2023-02-02
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

In line with the European Energy Strategy on H2020, intensified research on the development of more-efficient and cost-effective light emitting diodes (LEDs) is required. In this regard solution processable colloidal quantum dots (QDs) and metal halide perovskites (PS) showed excellent proficiency to realize effective devices with low fabrication cost on large-area and light-weight substrates. Despite the high potentiality of developing advanced LEDs by exploiting the combination of PS and QDs, the investigation of the interactions of both materials is still in its early stage; and much is yet to be discovered regarding the charge-transport dynamics, mobilities, and defect states in different compositions of these hybrid materials. Our project's research objectives address this crucial issue and focus on designing novel, lead-free, QD@2D-PS hybrids, optimize their composition through studying their electro-optical properties, and finally characterize their performance in LED devices. The project (LED4Nature) will provide detailed knowledge about the effectiveness of Sn based 2D PS as a matrix for lead-free near-IR emitting QDs, and understanding of the effect of structural modifications (QD size, shell thickness, and PS's cation) on their spatially- and temporally- resolved photo-induced phenomena by time-resolved transient absorption and femtosecond terahertz spectroscopy, along with fluorescence lifetime imaging microscopy. Such information will be essential for the optimization and acceleration in the development of LED devices based on these hybrid materials which will be achieved through planned secondments to an expert group- and is expected to have significant industrial and socio-economic impacts. Comprehension of such multidisciplinary project will not only provide the fellow excellent research training, but will also provide a skill-set of transferable skills which will improve and diversify the fellow's future employment perspectives.

Keywords: quantum dots,perovskite,excitons,charge carriers,ultrafast dynamics,laser spectroscopy,ligthing
Smart and Inclusive Solutions for a Better Life in Urban Districts (SMARTER TOGETHER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Germany,Germany,Austria,Germany,Italy,Germany,Switzerland,Belgium,Bulgaria,France,France,France,France
Call: Smart Cities and Communities solutions integrating energy, transport, ICT sectors through lighthouse (large scale demonstration - first of the kind) projects (H2020-SCC-2015, 2015)
Start date: 2016-02-01
End date: 2021-07-31
Duration (months): 66.0
Total project cost (EUR): 29699309.11
EU funding (EUR): 24742978.64
Participants: 54
Project status: CLOSED

SMARTER TOGETHER’s overarching vision is to find the right balance between smart technologies and organizational/ governance dimensions in order to deliver smart and inclusive solutions and to improve citizen’s quality of life. SMARTER TOGETHER gather the European Lighthouse cities Lyon, Munich, Vienna, the Follower cities Santiago de Compostela, Sofia, Venice and Kyiv and Yokohama as observer cities bringing the perspective of East Europe and Asia. The cities are complemented by business partners from energy, mobility and ICT sectors, leading European research and academia organizations, european city network. From the various combinations of the different selected Light House areas, multiples opportunities to learn are offering. SMARTER TOGETHER delivers 5 clusters of co-created, smart and integrated solutions: (1) Living labs for citizen engagement, (2) District heating and RES for low energy districts, (3) Holistic refurbishment for low energy districts addressing public and private housing, (4) Smart Data management platform and smart services (5) E-mobility solutions for sustainable mobility. Expected results are: 1) >151,800 m2 of refurbished buildings, primarily housing estate with a 50-60 % average energy and CO2 reduction; 2) 14.6 MW of newly installed renewable capacity; 3) 10/15new e-mobility solutions for passengers and freight); 4) 1400 created jobs, 130 M€ investments, all deployed with support of integrated ICT solutions and in dialogue with the inhabitants. Large-scale replication will be prepared; 1) in the Lighthouse cities; 2) the Follower cities, which already selected their target area; 3) A Club of 15-20 cities, associate to intensify its roll-out, ensuring a broad geographical and climate coverage. Commercial exploitation is enhanced by the development of new business models for widespread use by the stakeholders. Contributions to open data are expected to create business opportunities as well as inputs to standardization work.

Keywords: governance,citizen focus,integration,cocreation,smart city,business model,inclusive,large scale,data platform,low energy district,district heating,up scaling,bankability protocol,emobility