Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease. (AlzheimersInAction)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an alarming rate of 2-fold every 20 years, the outputs from AlzheimersInAction will contribute to the research output, visibility, and economy of Europe.

Keywords: glia,macrophage,drosophila,amyloid beta
Ecosystem mechanisms of noise impact on marine fauna (ECOSOUND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-10
End date: 2017-05-09
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Defining a Good Environmental Status for ocean noise within the EU Marine Framework Strategy is challenged by our limited knowledge about noise effects on marine fauna.ECOSOUND proposes that there are two broad types of mechanisms of noise impact on individual animals, both with potential population-level effects: bottom-up, i.e. noise responses that operate at the genetic, cellular or physiological level, which are likely to be conserved across taxa; and top-down, i.e. behavioural reactions driven by the life style of each species, which may result in physiological damage and even death.ECOSOUND will study bottom-up effects exploring if noise may induce morphological changes in several invertebrate taxa, selecting study species known to show phenotypic plasticity when exposed to stressors. Identifying developmental mechanisms of noise-effects is critical to predict potential common physiological paths over a wide range of taxa.Top-down effects will be investigated by comparing the life style of four species of deep-diving whales, and developing models to identify the reasons and potential consequences at the individual and population level of the different vulnerability of these species to noise. ECOSOUND will use the largest existing dataset of multi-sensor acoustic tag recordings of these whales, and apply quantitative ecology methods to develop bioenergetics models linking foraging and diving behaviour, metabolic rate, life history and social structure of the species.The results will inform transfer functions for PCAD models of population consequences of acoustic disturbance.ECOSOUND will strengthen the multidisciplinary research profile of the fellow with the fields of developmental biology and quantitative ecology, while contributing expertise on cetacean biologging studies and a new research line on the impacts of noise on marine invertebrates to USTAN.Results are relevant for the EU Marine Framework Strategy in the emergent field of management of ocean noise

Keywords: underwater acoustic pollution,noise effects,marine invertebrate larvae,developmental biology,deep diving whales,acoustic ecology,diving behaviour,passive acoustic monitoring
Solid-State Neutron Detector - A new Neutron Detector for High-Flux Applications (SoNDe)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Norway,France
Call: Design studies (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-05-01
End date: 2019-10-31
Duration (months): 54.0
Total project cost (EUR): 3800932.5
EU funding (EUR): 3800932.5
Participants: 6
Project status: CLOSED

The Solid-State Neutron Detector – SoNDe – project aims to develop a high-resolution neutron detector technique that will enable the construction of position-sensitive neutron detectors for high-flux sources, such as the upcoming European Spallation Source (ESS). Moreover, by avoiding the use of 3He in this detector the 3He-shortage, which might otherwise impede the construction of such large-scale facilities, can be alleviated. The main features of the envisioned detector technique are: • high-flux capacity, capable of handling the peak-flux of up-to-date spallation sources • high-resolution down to 3 mm by direct imaging technique, higher resolutions available by interpolation • no beam stop necessary, thus enabling investigations with direct beam intensity • independence of 3He • modularity, improving maintenance characteristics of today’s neutron detectors Detectors of these kind will be capable of usage in a wide array of neutron instruments at facilities which use neutrons to conduct there research, among them the Institute Laue-Langevin (ILL) in France, the Maier-Leibnitz-Zentrum (MLZ, former FRMII) in Germany, Laboratoire Leon Brillion (LLB) in France and ISIS in the United Kingdom which are in operation at the moment and the upcoming ESS. At these facilities neutrons are used as a probe in a wide array of fields, ranging from material science to develop new and smart materials, chemical and biological science to develop new drugs for improved treatment of a wide range of medical conditions, magnetic studies for the development of future information storage technology to archeology, probing historical artifacts without physically destroying them. All these fields nowadays rely heavily on neutrons scattering facilities in their research and thus are in need of a reliable, high-quality neutron detection technique, which will be able to perform well at the new high-flux facilities such as ESS and simultaneously avoid the problem of 3He shortage.

Keywords: neutron detector high flux high resolution physics modular scintillation 3he independence shortage
Towards a Reliable and Automated Analysis of Compromised Systems (BITCRUMBS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-08-31
Duration (months): 65.0
Total project cost (EUR): 1991504.0
EU funding (EUR): 1991504.0
Participants: 1
Project status: SIGNED

The vast majority of research in computer security is dedicated to the design of detection, protection, and prevention solutions. While these techniques play a critical role to increase the security and privacy of our digital infrastructure, it is enough to look at the news to understand that it is not a matter of "if" a computer system will be compromised, but only a matter of "when". It is a well known fact that there is no 100% secure system, and that there is no practical way to prevent attackers with enough resources from breaking into sensitive targets. Therefore, it is extremely important to develop automated techniques to timely and precisely analyze computer security incidents and compromised systems. Unfortunately, the area of incident response received very little research attention, and it is still largely considered an art more than a science because of its lack of a proper theoretical and scientific background. The objective of BITCRUMBS is to rethink the Incident Response (IR) field from its foundations by proposing a more scientific and comprehensive approach to the analysis of compromised systems. BITCRUMBS will achieve this goal in three steps: (1) by introducing a new systematic approach to precisely measure the effectiveness and accuracy of IR techniques and their resilience to evasion and forgery; (2) by designing and implementing new automated techniques to cope with advanced threats and the analysis of IoT devices; and (3) by proposing a novel forensics-by-design development methodology and a set of guidelines for the design of future systems and software. To provide the right context for these new techniques and show the impact of the project in different fields and scenarios, BITCRUMBS plans to address its objectives using real case studies borrowed from two different domains: traditional computer software, and embedded systems.

Keywords: incident response,computer forensics,embedded systems security
ViAjeRo: Virtual and Augmented Reality passenger experiences (ViAjeRo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-05-31
Duration (months): 69.0
Total project cost (EUR): 2443657.5
EU funding (EUR): 2443657.0
Participants: 1
Project status: SIGNED

ViAjeRo will radically improve passenger journeys using immersive Virtual and Augmented Reality to support entertainment, work and collaboration on the move. In Europe, people travel an average of 12,000km per year on private and public transport, in cars, buses, planes and trains. These journeys are often repetitive and wasted time. This total will rise with the arrival of fully autonomous cars, which free drivers to become passengers. The potential to recover this lost time is impeded by 3 significant challenges . Confined spaces: These limit interactivity, and force us to rely on small displays such as phones or seatback screens . Social acceptability: We may share the space with others, inducing a pressure to conform, inhibiting technology use . Motion sickness: Many people get sick when they read or play games in vehicles. Once experienced, it can take hours for symptoms to resolve VR/AR headsets could allow passengers to use their travel time in new, productive, exciting ways, but only if bold research is undertaken to overcome these fundamental challenges. ViAjeRo will use VR/AR to do adventurous multidisciplinary work, unlocking the untapped potential of passengers. They will be able to use large virtual displays for productivity; escape the physical confines of the vehicle and become immersed in virtual experiences; and communicate with distant others through new embodied forms of communication – all whilst travelling. This will be of great benefit to European society and open a new area for products and services. Our vision requires groundbreaking contributions at the intersection of HCI, neuroscience and sensing to: 1 Develop novel interaction techniques for confined, seated spaces 2 Support safe, socially acceptable use of VR/AR, providing awareness of others and the travel environment 3 Overcome motion sickness through novel multimodal countermeasures and neurostimulation 4 Tailor the virtual and physical passenger environment to support new,

Keywords: virtual reality,augmented reality,passengers,motion sickness,social acceptability of technology,interaction design
States of Need / States of Emergency: Towards a Political Grammar of Exigency (NOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

NOT is a critical study of the emergency-discourse of modern European politics. My thesis is that the political preoccupation with states of emergency tends to overlook – with dire consequences – underlying chronic and ostensibly less urgent socio-economic and ecological conditions, or what I call states of need. This structural relation is captured in the ambivalence of the German word 'Not,' which means at once emergency and need. Since the French Revolution, the history of European politics has been defined by an always asymmetrical negotiation of the tension between emergency and need. This asymmetric articulation of political life is perpetuated by habits of speaking about politics, which are in turn rehearsed in literary and historiographical genres for representing the political theater. For this reason, NOT is an exercise in political philology. I analyze the way in which the grammar of modern politics reproduces the myopic, dramatic, subject- and anthropocentric perspective that privileges emergency over need by addressing a diverse archive of literary and theoretical texts from the 18th century to the present. My research historicizes this political grammar with attention to biopolitics, revolutionary rhetoric, political economy and development economics, human rights discourse, and ecological and Anthropocene debates. In doing so my aim is to excavate alternative forms of expression that do justice to the nexus of need/emergency and thereby recover ways to better articulate the political challenges we face today. In the spirit of Horizon 2020, appreciating the place of Europe in the contemporary world involves understanding the complex legacy of emergency/need that continues to inform national and global politics – as the European migrant crisis, the climate emergency and now the corona crisis have made clear. NOT is a second-book project supplemented by satellite conferences, edited publications, a public lecture series and teaching at the LMU.

Keywords: political and social theory,biopolitics,anthropocene,ecocriticism,climate emergency,poverty,refugees,humanitarianism,human rights
Probiotic-based Ophtalmologic treatment for Bacterial and Allergic Conjunctivitis (PROBIOTEARS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2018-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Conjunctivitis is a major health issue affecting more than 1100 million people worldwide. Currently, the market for bacterial & allergic conjunctivitis is mainly covered by antibiotic eye drops and ointments, which have undesired effects in the eye microbiota and contribute to increase the resistances of pathogenic strains. Other treatments such as anti-inflammatory and antihistaminic drugs have also undesired side effects and are not useful as an immediate solution. AB-BIOTICS, a company with a broad expertise in developing functional ingredients for the pharmaceutical industry, has developed an innovative solution based on the use of probiotics. Probiotics are live micro-organisms allowing a fast and stable reestablishment of a healthy eye microbiota by providing: (1) faster anti-inflammatory and anti-histaminic effects; (2) antagonism to pathogens with no resistance risks; (3) protection against future/recurrent infections; and (4) avoidance of common side effects such as intraocular pressure rising. The effects of the selected probiotic strains have been validated through functional in vitro and in vivo tests and its safety for ocular application has also been assessed in toxicity trials in animal models. The industrial scaling up of the strain has already been achieved and is now ready for galenic formulation. In order to determine the key steps to bring PROBIOTEARS to the market within the next 2 years, the objectives of the presented feasibility study are: • Assess clinical ophthalmologists & users associations interest • Determine the most suitable formula for ophthalmic use • Define IPR strategy • Perform a deeper market & competitor analysis • Find key partners to carry out Supportive Clinical Trials in phase 2 • Assess Regulatory Requirements PROBIOTEARS is a solid high-potential innovation project aligned with AB-BIOTICS’ strategy which is expected to reinforce its European & global dimension, and generate an EBITDA of 2,14M€.

Keywords: probiotics,opthalmologic treatment
Geothermal Energy in Special Underground Structures (GeoUS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Finland,Czechia
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 796250.0
EU funding (EUR): 796250.0
Participants: 3
Project status: SIGNED

GeoUS will support increased research excellence in geothermal energy at VSB -Technical University of Ostrava, Czech Republic through close cooperation with Fraunhofer Institute, Germany and University of Vaasa, Finland. The ultimate goal is the development of multi-disciplinary research and innovation skills in the Czech Republic, focused on the fundamental and practical aspects of developing geothermal as a sustainable energy source. GeoUS will enable VSB to expand its network with leading research organisations in geothermal energy. It also involves young researchers to support future development of research activities impacting in the Moravia Region in line with the Regional and National Research and Innovation Strategy for Smart Specialization (RIS3 Strategy) and ESIF targets. The results will be widely shared with City Authority of Ostrava, Moravian-Silesian Regional Authority and also with authorities at national level. GeoUS will: 1. Transfer knowledge and build excellent research. 2. Increase scientific excellence in thermal characterization and mathematical modelling of heat flows and temperature fields and in measurement and control of energy flows. 3. Improve the scientific excellence and research capacity of VSB. 4. Increase the capacity of VSB for participation in future high-quality research activities and innovation in thermal energy in Central Europe. 5. Increase the interaction with and between the main players in the innovation process in Czech Republic for developing and exploiting geothermal energy. 6. Widen the visibility of VSB as a centre of excellence for thermal energy. 7. Engage with the public and citizens and young people on science related to thermal energy.

Keywords: geothermal energy,heat exchangers,heat storages,capacity building
Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors (SelectiveTGFb-inhib)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Transforming growth factor-b (TGFb) is a multifunctional cytokine which has important functions during embryonal development and in tissue homeostasis. In cancer, TGFb is often overexpressed and has both tumor suppressor effects (induction of growth arrest and apoptosis) and tumor promoting effects (stimulation of epithelial-mesenchymal transition (EMT) of tumor cells, stimulation of angiogenesis and cancer associated fibroblasts, and suppression of immune surveillance). Our aim is to elucidate the mechanisms for the pro-tumorigenic effects of TGFb and to develop selective inhibitors which can be used to suppress tumor invasiveness and metastasis in animal models, and later on for treatment of patients with advanced cancer. We think it is important to develop selective inhibitors, which do not affect the tumor suppressive effects of TGFb, since complete inhibition of TGFb may cause severe side effects and may even promote tumorigenesis. We plan to: 1. perform a systematic analysis of posttranslational modifications and interactors of the TGFb receptor I (TbRI) and II (TbRII), and determine their functional importance for the induction of various pro-tumorigenic pathways; 2. determine the mechanism whereby TGFb activates the tyrosine kinase Src, and its role in invasiveness and metastasis; 3. attempt to selectively inhibit the activation of phosphatidylinositol 3´-kinase by TGFb, in order to inhibit tumor cell survival and migration; 4. elucidate the functional role in the nucleus of the cleaved intracellular domain of TbRI, and attempt to inhibit its formation and thereby tumor metastasis; 5. determine the cellular compartment where the pro-tumorigenic signaling pathways are activated; 6. elucidate mechanisms for TGFb-induced EMT and develop candidate low molecular weight inhibitors that we have obtained from a screen, aiming at using them in vivo to suppress metastasis; 7. develop biomarkers to identity patient cohorts for treatment with selective TGFb inhibitors.