Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications (PEPTICAPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Israel,Spain,Finland,France,France,France
Call: Novel nanomatrices and nanocapsules (H2020-NMP-PILOTS-2015, 2015)
Start date: 2015-10-05
End date: 2018-10-04
Duration (months): 36.0
Total project cost (EUR): 3852293.75
EU funding (EUR): 3852293.75
Participants: 12
Project status: CLOSED

PeptiCaps aims at producing and validating a new family of stimuli-responsive nanocapsules able to encapsulate efficiently and protect specific active ingredients for skin care application. Those nanocapsules will be assembled by nanoemulsion technique using amphiphilic and biocompatible polypeptides diblock copolymers with one hydrophilic poly(ethylene glycol) block and one hydrophobic polypeptide block. Adjustment of the length of each block to finely tune the hydrophilic/Lipophilic balance of the macroemulsifier will allow the encapsulation of either hydrophobic or hydrophilic active ingredients. In addition, polypeptides block will be specifically designed to respond to changes in pH and the presence of enzyme occurring for the skin conditions targeted to allow a triggered release of the active ingredient. After scaling-up selected macroemulsifiers under GMP-like process, two manufacturing processes will be used for the production of the nanocapsules, i.e. high-pressure homogenizer and tubular flow contactor. The most promising process will be selected to produce selected nanocapsules. Physico-chemical properties and (eco)toxicity of the nanocapsules will be extensively characterised using techniques and protocols recommended by the EU Cosmetic regulation to establish their risk and safety assessment. The advantages of safe nanocapsules from PeptiCaps will be demonstrated on validated relevant skin models for each application. All results obtained will be gathered to constitute a Dossier for the validation of the nanocapsules as cosmetic product by the authorities. In addition, PeptiCaps will actively participate to the standardization for nano-safety by developing software to predict the toxicity of nanomaterials (CORAL). Finally, a business plan will be elaborated for the commercialization of PeptiCaps nanocapsules for all cosmetic applications as well as other markets (dermatology and food) to ensure full exploitation of the PeptiCaps technology.

Keywords: polypeptides,nanocapsules,nanoemulsion,economic viability,high pressure homogenizer,tubular flow contactor,nanosafety,skin care,commercialization,validation,cosmetic regulation,eco toxicit
Energy from water in motion: efficient, customisable off-grid hydro-electricity for rural areas with stream access (HYDROGO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

500 million people are expected to be without power by 2040 despite a 70% global increase in energy demand. Existing solutions will struggle to cater as on-grid solutions are already unreliable or absent in rural areas and developing countries. Efficient new renewable energy solutions are needed in order to maximise world-wide electricity production, whilst meeting climate targets. In Europe alone, more than 26,400 suitable locations for mini (<1MW) hydropower generation remain unexploited, partly due to poor accessibility or unsuitability of existing mini-hydropower solutions. HYDROGO, our mobile, small, easy- and fast-to-install hydropower solution, is designed to alleviate the electricity needs of individuals or communities by producing electricity from river currents and waterfalls, efficiently, and in locations where existing solutions cannot. We have developed two models based on the same technology: Euro-pallet mounted Drop&Go and container-based Plug&Go to meet micro (<100 kW) and mini (<1MW) electricity demands, respectively. The HYDROGO plants can produce current effects up to 600 kW, meaning that Plug&Go could power up to 1,350 households/year. Practical and theoretical testing at the The Norwegian University of Science and Technology has allowed us to develop a HYDROGO prototype, which produces at least 20% more energy per waterfall height than existing hydropower technologies. HYDROGO requires only anchoring but no building work for its installation and is highly customisable to user needs, can be easily relocated, and set-up as a hybrid power station as well as connected to the grid. HYDROGO is not immersed in streams and therefore undisruptive to the environment, easy to maintain and move, if needed. Amongst its many potential applications, HYDROGO is the perfect solution for difficult to access areas and disaster zones where off-grid power is needed immediately. Our vision is to be the world leader in supplying small-scale hydropower plant solutions.

Keywords: hydropower,small generation,rural electrification,off grid solutions
A Genealogy of Corruption. Administrative Malpractice and Political Modernization in Eighteenth Century Wallachia (GenCorr)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The transition from the Old Regime to modern European states in the 18th and 19th centuries entailed a transformation in the meaning of “corruption”. While seen as a moral failure from Antiquity to the Early Modern period, with the separation of the public and private domains in the 18th and 19th centuries, corruption came to be strictly defined as the abuse of public office. Until now, this particular transition has been studied only in Western and Northern Europe and in North America, where the reduced level of administrative corruption came to be seen as part and parcel of successful state-building. Although corruption in Southeastern Europe has received ample attention, it has been mostly treated as a quasi-natural characteristic of the region, and completely ignored as a problem of governance. My project addresses this problem by scrutinizing the emergence of the problem of administrative malpractice in the long 18th century Wallachia. Based on archival and published sources (judicial decisions, regulations, chronicles, travelogues etc.), the project offers the first systematic study of the practices which can be called corrupt, of the discourses about corruption and of the reaction of contemporaries to this phenomenon. The importance of the project lies in throwing light on processes of modernization in Southeastern Europe prior to the adoption of the Western cultural and political model during the 19th century.

Keywords: corruption,patronage,modernization,state,administration,wallachia
DNA replication timing and spatial organization of chromatin (REPTIMORG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Replication timing is observed in all eukaryotes analyzed so far suggesting an important and conserved function. Despite significant advancement in the field, the molecular control of the replication-timing program is still largely unknown. The Buonomo laboratory has recently done very innovative work in this area. After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replication-timing establishment. This provided the first molecular evidence linking 3D nuclear organization and replication-timing control. However, Rif1 is a complex protein whose structure-function is not fully understood and it is not clear yet if the link between 3D nuclear organization and replication-timing control is specific to Rif1 or a general paradigm. A major aim of this proposal is to investigate if chromatin architecture plays a general role in replication-timing control. To this end, I will perform replication-timing and chromosome-conformation studies using mouse models which allows me to conditionally delete genes encoding for key regulator of nuclear structure, such as cohesin (Rad21) and Lamin B1. I aim with this proposal to advance the understanding of how spatial organization of chromatin regulates and integrates different nuclear functions, with a specific focus on DNA replication.

Keywords: nuclear organization,chromatin,dna replication
Skills and competences development of future transportation professionals at all levels (SKILLFUL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Italy,Italy,Germany,Italy,Belgium,Finland,Greece,Lithuania,Slovakia,Greece,France,France,France,France,Netherlands,United Kingdom,Portugal
Call: Assessing future requirements for skills and jobs across transport modes and systems (H2020-MG-2016-SingleStage-INEA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 2991672.2
EU funding (EUR): 2991672.2
Participants: 25
Project status: CLOSED

The Transportation sector employs over 10 million persons in the EU today. At the same time, Transport is a social sector that is rapidly developing, changing and being influenced to the maximum extent by the development of automation, electrification and greening of transport, among others, thus facing problems in staffing its several domains with appropriate and qualified personnel. This fact, makes the need for changes in training and education content, curricula, tools and methodologies absolutely imperative, incorporating lifelong learning aspects for the professionals in all transports areas. SKILLFUL vision is to identify the skills and competences needed by the Transport workforce of the future and define the training methods and tools to meet them. For all the above trends, employability will be strongly connected by SKILLFUL to future transport job requirements for all transportation modes and multimodal chains (which constitute a key transport of the future trend) and for all levels/types of workers, while all training modes will be included and integrated in a balanced way. To achieve this, SKILLFUL aims to review the existing, emerging and future knowledge and skills requirements of workers at all levels in the transportation sector, to structure the key specifications and components of the curricula and training courses that will be needed to meet these competence requirements optimally and to identify and propose new business roles in the education and training chain, such as those of “knowledge aggregator”, “training certifier” and training promoter”, in order to achieve European wide competence development. Project results are verified through s wide number of Pilots with low to high skilled workers from all transportation modes Europewide.

Keywords: qualifications,skills,competences,transport future workforce,all transport modes,training methods,curricula training tools,job requirement s,educational content,lifelong learning
Unveiling the signature of transposable elements-derived transcripts – the transposcriptome – as a biomarker in human acute myeloid leukemia (LEUKEMIC-TEs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Acute myeloid leukemia (AML) is the most common of the acute leukemias among adults. Relapsed AML patients are frequent but difficult to treat since effective therapies are limited. This mediocre outcome can be partially explained by the presence of leukemia stem cells (LSC) that maintain an aberrant hematopoietic process. LSC in AML were traditionally thought to be solely CD34+CD38- cells. However, recent studies demonstrated the presence of LSC in cell fractions thought to be non-tumorigenic. Finding an LSC-specific signature would be decisive for a better categorization of patients and LSC exclusive targeting. This project considers the signature of transposable elements (TEs) as an ideal tool for the identification of LSC. TEs, with important roles in gene regulation, are linked to the reprogramming process to pluripotency and they are associated with tumorigenesis. Since they contribute up to two thirds of the human genome, TEs expression provides much denser coverage of chromosomes than gene-derived transcriptome. TEs signature in cancer has so far been largely unexplored per lack of proper technologies. The advent of high-throughput sequencing and the development of TE-directed analytical pipelines allow now the accomplishment of this project. The present proposal includes a comprehensive characterization of TEs transcriptome in normal and malignant hematopoietic precursors. An expected result is the achievement of a better subclassification of AML samples on the basis of their TEs expression homology to normal progenitors. The project will investigate the existence of TE-derived oncoproteins exclusive for LSC that could be immunotherapeutically targeted. This proposal has impact on the excellence of European science since it will create new collaborations and networks to find AML biomarkers. It would bridge academy with industry and will bring invaluable complementary scientific and soft skills to a researcher with an ideal background in cancer epigenetics.

Keywords: transposable elements,transposcriptome,acute myeloid leukemia,biomarker,stem cells,genome regulation,bioinformatics
EERA SEcretariat 3 (EERASE3)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Germany,Italy,Norway,Finland,Belgium,France,Denmark
Call: Grant to named beneficiary to support the operations of the European Energy Research Alliance (EERA) (H2020-IBA-ENERGY-EERASE-2016, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 1150308.75
EU funding (EUR): 600000.0
Participants: 7
Project status: CLOSED

The purpose of EERA is to strengthen and expand Europe’s capabilities in sustainable energy research by connecting and joining European energy research activities. EERA’s efforts take place in the context of and contribute to the targets formulated in the Strategic Energy Technology (SET) Plan. The core activity of EERA is the operation of the EERA Joint Programmes. EERA currently runs 17 Joint Programmes. The EERA Joint Programmes are strategic platforms for cooperation and joint programming between major research organisations on common research agendas. Active in diverse areas such as wind energy, smart grids, advanced materials and energy storage, the Joint Programmes represent today an important part of Europe’s energy research backbone. Through the Joint Programmes, EERA support Member States in their efforts to coordinate their long-term energy research activities. Serving as the research arm of the SET-Plan, the EERA Joint Programmes are developing into a sort of “Virtual European Institute on Energy Research”, working in open collaboration with innovation and industrial initiatives and stakeholders. In order to provide support to the different EERA bodies (Executive Committee, Joint Programmes) and ensure efficient operations, the EERA Secretariat was established in 2010. The main objective of the EERA Secretariat is to support EERA as key actor in the implementation of the integrated SET Plan by: • Accelerated EU delivering on the SET-Plan priorities • Ensure a more transparent and better functioning EERA • Strengthen EERA structuring effects on the energy research community

Keywords: eera,set plan,energy union,low carbon technologies
Developing an interdisciplinary Collaborative Self-Management Support model: behavioural and communication tools for integrated care (CoSMaS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-03
End date: 2019-04-02
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The CoSMaS project aims to develop and test an interdisciplinary Collaborative Self-Management Support Model applicable to several chronic health conditions and to validate model measurement tools for use in research and routine care. The proposed research investigates how different HCPs contribute to supporting self-management, how they coordinate care, and how this can be improved to ensure comprehensive (but not redundant) care and ultimately reduce illness burden. It thus addresses recent calls to improve chronic care in Europe, in line with recent advances towards integrated care and current interest in using social science, especially health communication and behaviour change, to inform health services research. Within a 2-year timeline, it proposes a community-based participatory research approach to develop solutions for collaborative care in France in asthma, stroke and cancer based on input from various stakeholders, while also developing the model internationally via collaborations with other EU research centres. Theoretical literature reviews are first planned to inform model development. Qualitative studies are set to explore the views of patients’, caregivers’ and health care professionals of different specialities on current and desired CoSMaS practices. An international Delphi consultation aims to reach consensus on model elements and hypotheses by synthesizing opinions of research and management experts. Self-report tools are developed, piloted and validated in a cross-sectional online survey. This research is linked to relevant training, knowledge transfer and communication activities to broaden the expertise of the researcher, valorize her current knowledge within the host and partner organizations, and disseminate scientific evidence on collaborative self-management support to scientific audiences and the public at large.

Keywords: health psychology,behavioral science,health communication
Raman spectroscopy for early diagnosis of oral pre-cancer and cancer using minimally invasive samples (RAMAN-Dx)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 2
Project status: CLOSED

The Experienced Researcher (ER), Dr Amuthachelvi Daniel, who is at the centre of this application, will, through this MSCA Fellowship, enhance her research and innovation potential through advanced training and international and inter-sectoral mobility. RAMAN-Dx will develop methods for detecting pre-malignant oral lesions using Raman spectroscopy of minimally invasive exfoliated cell and saliva samples. The ER’s skills in instrument and software development and patient testing will complement the expertise of the host laboratory, Radiation and Environmental Science Centre (RESC) at Dublin Institute of Technology (DIT), led by Prof. Fiona Lyng. The ER will receive both research and professional development and leadership training and will undertake a secondment at VTT Technical Research Centre of Finland Ltd which will facilitate her career goal to become a world leading researcher in the field of biophotonics.

Keywords: raman spectroscopy,oral cancer,oral dysplasia,exfoliated cells,saliva