Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New Paradigms for MEMS & NEMS Integration (M&M´S)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Sweden
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2017-10-31
Duration (months): 72.0
Total project cost (EUR): 1495982.0
EU funding (EUR): 1495982.0
Participants: 1
Project status: CLOSED

Micro- and nanoelectromechanical system (MEMS and NEMS) components are vital for many industrial and consumer products such as airbag systems in cars and motion controls in mobile phones, and many of these MEMS and NEMS enabled applications have a large impact on European industry and society. However, the potential of MEMS and NEMS is being critically hampered by their dependence on integrated circuit (IC) manufacturing technologies. Most micro- and nano-manufacturing methods have been developed by the IC industry and are characterized by highly standardized manufacturing processes that are adapted for extremely large production volumes of more than 10.000 wafers per month. In contrast, the vast majority of MEMS and NEMS applications only demands production volumes of less than 100 wafers per month in combination with different non-standardized manufacturing and integration processes for each product. If a much wider variety of diverse and even low-volume MEMS and NEMS products shall be exploited, the semiconductor manufacturing paradigm has to be broken. In this project, we therefore will focus on frontier research on new paradigms for flexible and cost-efficient manufacturing and integration of MEMS and NEMS within three related research areas: (1) Wafer-Level Heterogeneous Integration for MEMS and NEMS, where we explore new and improved wafer-level heterogeneous integration technologies for MEMS and NEMS devices; (2) Integration of Materials into MEMS Using High-Speed Wire Bonding Tools, where we explore new ways of integrating various types of wire materials into MEMS devices; (3) Free-Form 3D Printing of Mono-Crystalline Silicon Micro- and Nanostructures, where we explore entirely novel ways of implementing mono-crystalline silicon MEMS and NEMS structures that can be arbitrarily shaped.

Keywords: wafer-level heterogeneous integration,mems,nems,ic integrated mems,3d free-form fabrication,wire bonding
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Denmark,Netherlands,Belgium,Germany,Germany,Italy,United Kingdom,Denmark,Sweden,Netherlands
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2016-11-30
Duration (months): 60.0
Total project cost (EUR): 16116735.99
EU funding (EUR): 11982403.0
Participants: 13
Project status: CLOSED

Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remodelling and Deacetylation (NuRD) complex and the Polycomb Repressive Complexes (PRCs), modulate chromatin structure to control stem cell renewal, lineage commitment and differentiation. Moreover, they are clearly implicated in cancer. The goal of 4DCellFate is to understand how the PRC/NuRD complexes and their plethora of interactions (protein/protein, protein/nucleosome, protein/nucleic acids) regulate cell fate. To obtain this global, quantitative and dynamic – 4D – understanding of the structure/functions of these two multi-protein machines during ES cell differentiation and in different disease states, we propose a large scale multi-disciplinary “data-gathering” approach combining European excellence in interactomics (affinity purification, quantitative mass spectrometry-based proteomics, ChIP-seq analysis, light microscopy), structural biology (X-ray crystallography, NMR, native-state mass spectrometry, Electron Microscopy, biochemistry/biophysics), cellular, tumour, and computational biology. We expect to significantly advance the technology, mainly in the fields of proteomics, structural biology, and small molecule screening, and to make our knowledge, reagents and data publicly available to the scientific community. The ultimate outcome of 4DCellFate will be to lay the foundations for understanding the role of the PRC/NuRD complexes in ES cell differentiation and cancer, specifically in leukaemogenesis. Three SMEs and one large multi-national pharma will be actively involved ensuring that our findings can be translated into new ways to control complex diseases.

Keywords: polycomb repressive complexes,nurd complex,stem cells,cancer,differentiation
Development and validation of an integrated methodology in order to establish adapted production concepts for efficient turbofan engines (IMAPC)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-03-01
End date: 2013-06-30
Duration (months): 28.0
Total project cost (EUR): 960000.8
EU funding (EUR): 719999.0
Participants: 1
Project status: CLOSED

The aerospace industry is currently faced with the development of new efficient turbofan engines, focused on fuel burn reduction combined with an additional decrease in noise emission. The upcoming engine programs and their components require new approaches regarding product materials, product design, engineering as well as challenging demands on supplier und supply chain processes. Based on the development of these new efficient turbofan engines, also the manufacturing process of the new programs has also to be considered within the integrated clean sky approach. The major changes of the new products and product structures require that the high level strategy of manufacturing new turbofan engines and components has to be reviewed as well as the specific production concept on the shop floor. The production has to fulfil the future requirements of integrating new production technologies, shortening product life-time cycles, achieving target costs of manufacturing and decreasing lead time as well as increasing quality demands. Additionally, the production is encountered within volatile environment with fasten changing constrains and parameters regarding production volumes, product design changes and new technology processes. Currently, engines and parts manufactures are mainly based on widespread manufacturing strategies and conventional production concepts. Based on general competences for production/logistics systems, the specific knowledge for the production processes within the aircraft industry as well as for the development of methodologies ifp consulting will establish a specific methodology. Beginning with the definition of the methodology approach and a detailed analysis of existing requirements, concepts and targets, ifp build up a methodology structured by different detailed levels of an integrated production concept. The methodology itself has to fulfil the requirements of a robust, sustainable, systematic, repeatable and efficient proceeding.

Keywords: integrated methodology,production concept,sustainable,repeatable,efficient,aero engine,tool
Active Flow Control Technique on Trailing Edge Shroud for Improved High Lift Configurations (ATTESI)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany,Sweden,Germany
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-06-01
End date: 2014-02-28
Duration (months): 33.0
Total project cost (EUR): 459780.6
EU funding (EUR): 344834.0
Participants: 4
Project status: CLOSED

The subject of the proposed project ATTESI is the design and evaluation of flow control techniques to improve the separation behavior on a drooped spoiler configuration. The proposed project comprehends numerical evaluation and optimization of the spoiler droop together with different flow control approaches applied upstream of the kink (the effect of the droop) and at the trailing edge of the spoiler. The techniques are the application of fluidic vortex generator jets (VGJs) upstream of the kink and a fluidic gurney (FG) at the trailing edge of the spoiler. The two AFC-techniques will be able to operate both in static and in pulsed (dynamic) mode. The pulsed VGJs will be designed in a two-step-procedure using state-of-the-art numerical tools to generate a validation dataset and experience the basic sensitivities. Further design and optimization will be performed based on a statistical model. The fluidic gurney will be applied at the lower side of the trailing edge. It will be designed within a numerical optimization loop together with the spoiler droop angle. The numerical analysis will be accompanied by experimental work that will be conducted in the 1.3m-windtunnel at TU-BS up to Reynolds numbers of 2 Mio. The VGJs as well as the fluidic gurney will be integrated into a drooped spoiler model of an airfoil model with DLR-F15 contour. The proposed project will cover the elaboration of a structural model for the drooped spoiler consisting of a “smart surface”, which enables to droop the spoiler while remaining a smooth surface. The structural design will be based on finite element analysis and will be continued within the project to a demonstrator model for the smart surface. The results will be analyzed with respect to effectiveness, efficiency and towards swept wings.

Keywords: drooped spoiler,trailing edge active flow control,fluidic gurney,vortex generator jets,optimization,windtunnel testing,structural concept,structural model
Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Poland,Italy,Netherlands,United States,United Kingdom,Slovenia,Germany,Canada
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 6977141.23
EU funding (EUR): 5215219.8
Participants: 13
Project status: CLOSED

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to halt or reverse PKAN or any other NBIA. This is especially unfortunate as both the iron accumulation in NBIA and the biochemical defect in PKAN are predicted to be amenable to drug-based treatment. Thus, the current absence of clinical trials is not due to lack of therapeutic options but to rarity of the disease, lack of patient registries and fragmentation of therapeutic research worldwide. For example, the iron-chelating drug deferiprone has been administered to PKAN patients on an individual basis or in pilot trials, both precluding firm conclusions about its efficacy. With TIRCON, we will address this urgent and unmet need for NBIA/PKAN therapy with an ambitious and highly collaborative plan that leverages worldwide expertise. We propose a large investigator-driven randomized clinical trial of deferiprone in PKAN, bringing together leading centres and patient advocacy groups from Europe and the US to reach the required patient cohort size. In addition, together with a European SME, we propose to pursue preclinical development of pantethine and its derivatives which have shown promising efficacy in a Drosophila PKAN model. To facilitate future research, we will develop a harmonized patient registry and biomaterial bank to allow for natural history studies and biomarker development, two critical needs in NBIA research. TIRCON partners, apart from their unique clinical and basic science expertise in NBIA, have longstanding experience in investigator-driven and industry-driven randomized clinical trials. Importantly, they have been closely collaborating in recent years.

Keywords: nbia,pkan,iron-chelation,deferiprone trial,pantethine derivatives development,new therapeutic options,drug development,standardized database,natural history study,nbia educational training
The h-Principle for Fluid Dynamics (HPFLUDY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 870000.0
EU funding (EUR): 870000.0
Participants: 1
Project status: CLOSED

A fundamental problem of the theory of turbulence is to find a satisfactory mathematical framework linking the Navier-Stokes equations to the statistical theory of Kolmogorov. A central difficulty in this task is the inherent non-uniqueness and pathological behaviour of weak solutions of the Euler equations, the inviscid limit of the Navier-Stokes equations. This non-uniqueness, rather than an isolated phenomenon, turns out to be directly linked to the celebrated construction of Nash and Kuiper of rough isometric embeddings and, more generally, to Gromov's h-principle in geometry. The central aim of this project is deepen the understanding of this link, with the following goals: I. Scaling Laws. Attack specific conjectures concerning weak solutions of the Euler equations that are motivated by the Kolmogorov theory of homogeneous isotropic turbulence. Most prominently the conjecture of Onsager, which relates the critical regularity requiring energy conservation to the scaling of the energy spectrum in the inertial range. II. Selection Criteria. Study the initial value problem for weak solutions, with the aim of characterizing the set of initial data for which an entropy condition implies uniqueness, and obtaining information on the maximal possible rate of energy decay and identifying selection criteria that single out a physically relevant solution when uniqueness fails. III. General Theory. Identify universal features of the construction, in order to be applicable to a large class of problems. This involves an analysis of the geometry induced by the equations in an appropriate state space, a better understanding of how an iteration scheme using only a finite number of "cell-problems" can be developed, and developing versions of convex integration that use higher-dimensional constructions.

Keywords: turbulence,fluid dynamics,h-principle,euler equations
New Method for Superior Integrated Hydrogen Generation System 2+ (NEMESIS2+)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Germany,Netherlands,United Kingdom,Spain,Greece,Portugal
Call:  (FCH-JU-2010-1, 2010)
Start date: 2012-01-01
End date: 2015-06-30
Duration (months): 42.0
Total project cost (EUR): 3393341.0
EU funding (EUR): 1614944.0
Participants: 7
Project status: CLOSED

Decentralized hydrogen production at refuelling stations has great potential to accelerate market introduction of hydrogen-powered vehicles. Based on the outcome of the previous NEMESIS project under FP6 the overall objective of the proposed NEMESIS 2+ project is the development of a small-scale hydrogen generation prototype capable of producing 50 standard cubic metres of hydrogen per hour from diesel and biodiesel at refuelling stations. Reduction of hydrogen production costs and an increase of reliability and efficiency of the hydrogen generation system will be the major objectives. Special emphasis will be placed on liquid desulphurisation prior to the catalytic conversion step. Based on the promising results from the NEMESIS project, a desulphurisation module based on liquid adsorption for continuous operation will be built and tested with fossil diesel, biodiesel and biodiesel blends. Thereby severe problems relating to catalyst deactivation can be avoided or at least minimized. This will be supplemented by the development of sulphur-tolerant reforming and water gas shift catalysts and the development of catalyst regeneration strategies. The liquid desulphurisation module will be connected to a reformer module based on a modified steam reforming technology owned by HyGear. By a subsequent water gas shift stage and a pressure swing adsorption unit a hydrogen purity of 5.0 (99,999 %) is achieved. In order to be able to run on liquid fuels as well as on off-gas from the hydrogen purification unit, a dedicated dual fuel burner will be developed within NEMESIS2+. Once the prototype modules (desulphurisation module, multi-fuel catalyst, reformer module) are integrated into the prototype unit the system will be tested for at least 1000 hours. Work will be completed by a techno-economic evaluation of the prototype hydrogen generation system (Cost analysis, Study on integration into refuelling stations).

Keywords: on-site hydrogen production,diesel,biodiesel,steam reforming,sulphur resistant catalyst,liquid desulphurization,thermal heat integration
Development of Thermoplastic Polymer blend with Low Melting Point and with Similar Properties than PEEK (SUPERBLEND)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-04-01
End date: 2012-09-30
Duration (months): 18.0
Total project cost (EUR): 199504.0
EU funding (EUR): 149628.0
Participants: 1
Project status: CLOSED

Since thermoplastic matrices can be replacing thermoset matrices in aircraft structural applications, the next step is to get eco-friendly thermoplastic materials able to be manufactured with less energy than PEEK. It is therefore necessary to develop an innovative compound with similar mechanical and physic-chemical properties than PEEK but with lower melting point in order to reduce the energy for its processing and minimize the environment impact. The development of this blend will be focused on the investigation of new generation additives developed in the last years such as thermal stabilizer, halogen free flame retardant, nano-additives (CNT, nanoclays and nanoparticles)… In the course of the project, different formulations will be tested in the extrusion-compounding process. These formulations will consider different proportions and types of advanced thermoplastics and additives. Twin-screw extrusion machine will be used in the development of the blend in order to guaranty the best method to mix additives and polymers and therefore get a homogenous blend with the desirable characteristic to be used in aeronautic applications. The project will start the 1st of April 2011. This date has been reached a consensus with the TM who wants to start the project as soon as posible.

Keywords: compounding,nanoadditive and additives,advanced thermoplastic composite,blend,characterisation,low processing temperature,twin-screw extrusion machine,aircraft structural application.
Multi-modal effects of thyroid hormone replacement for untreated older adults with subclinical hypothyroidism; a randomised placebo-controlled trial (TRUST)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Ireland,Netherlands,Switzerland
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-11-01
End date: 2017-04-30
Duration (months): 66.0
Total project cost (EUR): 7764598.4
EU funding (EUR): 5963787.0
Participants: 5
Project status: CLOSED

Subclinical hypothyroidism (SCH) is a common condition (8-18%) among European older men and women. Although by definition SCH comprises biochemically mild thyroid hormone deficiency without overt symptoms, it is a likely contributor to multiple problems in older age. Thyroid hormone has multiple pleiotropic effects on numerous physiological systems, including the vascular tree, heart, skeletal muscle and brain. Therefore, thyroxine substitution to overcome thyroid hormone deficiency has the potential to give multi-system benefits to older people with SCH. Small studies have reported reduced atherosclerosis and improved cardiac function with thyroxine replacement, but no large clinical trials have been performed. Therefore the available evidence is limited, leading to major variations in guidelines and clinical practice, with uncertainty regarding the indications for screening and treatment. We are conducting a multicentre randomised placebo-controlled trial to assess the impact of thyroxine replacement. We have recruited 738 older adults with persisting SCH (excluding those in whom it is a temporary phenomenon who are less likely to benefit). We have included older men and women with a wide age range and of varying health status. Outcomes include health-related quality of life, cardiovascular events, muscle strength and executive cognitive function over 3-years of follow-up. We have the support of patient advocacy groups and a consortium with the wide range of expertise and experience required to conduct large-scale multicentre clinical trials. The proposal fits with the call, exploring the multi-system and quality-of-life benefits to older people of a tailored approach to management of SCH. This clinical trial should definitively clarify whether thyroxine treatment for SCH provides benefits that are relevant for patients. This trial will provide strong evidence with the potential to improve clinical practice, reduce healthcare costs and promote healthy ageing of European older adults.

Keywords: aged,subclinical hypothyroidism,thyroxine,thyroid stimulating hormone,multi-morbidity,cardiovascular disease,muscle strength,cognitive function,quality of life