Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Robust Control Strategy for Dynamic Lane Change of Intelligent Articulated Heavy Vehicle in Complex Traffic Environment (RACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The complex traffic environment with dynamic changes of speed and acceleration of multi-surrounding vehicles, and adhesion coefficient and curve radius of the road, results in that the optimal and precise control of lane change for intelligent articulated heavy vehicle (IAHV) is difficult to be achieved. According to the real-time states of multi-surrounding vehicles and road parameters, the real-time safe optimal trajectory of lane change is obtained by setting the multi-objective function considering efficiency, jack-knife, yaw and roll stability. The dynamic thresholds of each control mode, which are modified by real-time trajectory and road parameters, are obtained, and then the multi-mode switching mechanism is established by deep neural network. The vehicle parameters and states are accurately estimated by using an estimator with multi-estimation algorithms combining steady state with dynamic state. Considering the parameter uncertainty, a robust control strategy based on a linear parameter-varying model is designed to real-time achieve precise and optimal tracking control of dynamic trajectory and maintain vehicle stability by optimizing weight coefficients and multi-mode switching. Thus, the safe and optimal lane change of IAHV under normal and extreme conditions with different velocities and loads is realized. The proposed control strategy is verified on HIL bench. The research results will provide theoretical basis for IAHV control in complex traffic environment. This project provides a unique knowledge exchange from leading experts in different fields (vehicle, control, mechanical, transportation, optimization, motor, pneumatic) to solve the challenges in IAHV. The fellow will benefit from not only the scientific impact of the work but also exposure to new techniques and collaborative networks in different disciplines. The dedicated training and high scientific value will help the fellow to become an independent researcher in a world-leading institution.

Keywords: intelligent vehicle dynamic lane change trajectory planning and tracking robust control parameter and state estimation
Sustainable Urban Strategies Through Adaptive reuse for Integrated Neighbourhoods (SUSTAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Cities across Europe are facing a surplus of vacant properties, while the housing shortage is reaching a critical threshold. Adaptive Reuse (AR) practices are emerging as a convincing approach to address the challenges of escalating housing demands, while facilitating the transition towards a circular economy. Recently, municipal programs have emerged across the EU to address the housing crisis by extending regulatory flexibility to ease the provision of affordable housing through AR of unused buildings. As these programs are still in their early development stage, a body of theoretical knowledge or evidence-based guidance in this domain is absent. The lack of standardized frameworks hampers a comprehensive evaluation of the impacts of projects of Adaptive REuse for Affordable Housing (AREAHs), and no research has been undertaken to determine the extent to which these may contribute to changes in the social and environmental well-being of neighborhoods. More study is also required to evaluate the role of existing regulatory frameworks in hindering or facilitating the implementation of AREAHs. SUSTAIN will answer these questions through a comparative analysis of AREAHs in 5 EU cities, so as to: RO1) Assess their housing impact and environmental enhancement value—through a quantitative analysis of selected performance indicators; RO2) Identify regulatory roadblocks and/or trailblazing policy instruments that facilitate AREAHs—through in-depth interviews with experts and discourse analysis of municipal policies; RO3) Assess AREAHs’ long-term contribution to neighborhood reactivation—through a longitudinal neighborhood data analysis. In a context in which municipalities strive to tackle the housing crisis while minimizing their carbon footprints, it is timely and urgent to assess the impact of AREAHs, evaluating wins and drawbacks. SUSTAIN will provide an evidence base on AREAHs across the EU and reflect on what steps might be taken to expand their scope of activity.

Keywords: adaptive reuse,housing,affordable housing,social housing,housing policy,environmental planning,circular economy,retrofit,urban planning,urban policy,regeneration
Decoding consequences of complex chromosomal aberrations by multi-modal single-cell deconstruction to overcome treatment-resistance cancer (SHATTER-AML)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 2499375.0
EU funding (EUR): 2499375.0
Participants: 1
Project status: SIGNED

How does a cell with unstable, complex genomic rearrangements stay alive, and even give rise to aggressive, highly resistant malignancies? This question remains an ultimate research challenge for cancers with highly aberrant genomes, such as acute myeloid leukemia with complex karyotype (CK-AML). Its etiology, time-resolved clonal dynamics, molecular heterogeneity, and treatment resistance mechanisms are still largely elusive. In particular, the genetic and non-genetic dynamics that drive cancer progression under treatment are elusive to current technologies and escape single-cell resolution. SHATTER-AML will tackle the genomic enigma of CK-AML by analyzing longitudinally obtained triplicate (diagnosis, treated, relapse) samples to examine intra-patient genetic and non-genetic heterogeneity using scNOVA-CITE, a newly developed multi-modal single-cell omics approach. This approach combines (i) structural variation discovery with nucleosome occupancy and cis-regulatory element accessibility profiling (scNOVA) with (ii) cellular indexing of transcriptomes and epitome sequencing (CITE-seq). We will uncover multi-level disease dynamics at single-cell and subclonal levels along the disease course, providing a blueprint for studies of other structurally instable cancers. Identified molecular insights into the networks mediating therapy resistance, leukemic stem cell activity and immune escape will be further explored functionally in patient-derived in vivo models. Pharmacological interference and CRISPRi are used to engineer deregulated signaling pathways for precision oncology, and CRISPRa screens are applied to sensitize CK-AML stem cells to natural killer cell-mediated elimination. • SHATTER-AML will fundamentally transform our understanding of the impact of clonal evolutionary dynamics of malignancies triggered by aberrant genomes and aims to develop novel preclinical strategies to combat CK-AML resistance via immunological and precision oncology approaches.

Keywords: aml with complex karyotype,stem cells,nk cells,single cell technologies,therapy resistance
Empowering physicians to provide every stroke treatment with the right treatment in time, with StrokeFlow (StrokeFlow)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 3204638.75
EU funding (EUR): 2235809.5
Participants: 1
Project status: SIGNED

Stroke patients represent the most time critical field of emergency medicine. Every minute counts when it comes to stroke – every minute delay in treatment leads to 22 healthy days lost. No comprehensive solution exists that solves the life-threatening bottlenecks in the complex stroke acute care chain, resulting in 1/3 of patients dead and 1/3 becoming disabled. The main challenge is that stroke care specialists are essentially “treating in the dark”. They lack the speed to share accurate patient data in real-time with colleagues, and they have no readily accessible information at all about the blood clot causing the stroke. All stroke patients are inevitably treated ineffectively in a “one size fits all” approach as physicians “go in blind” every intervention. It is our mission to empower physicians to treat every stroke patient in time with the right treatment. With StrokeFlow, we for the first time enable this with ground-breaking technology and innovative solutions.

Keywords: stroke,emergency care,artificial intelligence,patient care,automation,personalized treatment,communication and collaboration
Solar to Butanol – Solar Butanol Production by Solid-state Photosynthetic Cell Factories (S2B)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Finland,France,Sweden,Netherlands
Call: Improvement of light harvesting and carbon fixation with synthetic biology and/or bio-inspired//biomimetic pathways for renewable direct solar fuels production (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4015911.5
EU funding (EUR): 4015911.5
Participants: 8
Project status: SIGNED

Biomass, a byproduct of natural photosynthesis, has been explored for its potential conversion into energy carriers, particularly biofuels. However, acknowledging the long-term limitations in biomass supply, as highlighted by the European Commission in the EU Bioeconomy Strategy Progress Report (2022), there is an urgent need for the development of advanced bioinspired technologies that mimic nature but exhibit higher efficiency. The S2B project aims to unlock the potential of photosynthetic microbes for the direct conversion of solar energy and CO2 into butanol by employing innovative concepts and approaches. Specifically, S2B will transfer the microbial production of butanol from conventional suspension cultivation to a tailored solid-state biocatalytic platform. In this platform, engineered thin-layer assemblies of cyanobacteria and bio-based matrix materials will synergistically enable the redistribution of cell resources, such as energy and carbon flows, towards butanol formation. Simultaneously, S2B will improve light management, enhance CO2 capture efficiency, and facilitate downstream processes by separating butanol from the production medium. Consequently, the primary technological innovation of S2B will be the continuous, long-term direct solar butanol production by photosynthetic cell factories acting as biocatalysts. The process will be integrated with waste effluent and direct air capture, covering the entire value chain from light harvesting and CO2 capture to product separation through the circular economy concept. Acting as a multidisciplinary consortium, S2B will construct a TRL4-level prototype, paving the way for a smooth upscaling process.

Keywords: synthetic biology,photosynthesis,biocatalytic production,engineered living materials,nanocellulose,cyanobacteria,photobioreactor,solar fuels,immobilization,solar butanol,algae
Ultrafast broadband sensitive magneto-chiroptical microscopy to track the consequences of symmetry breaking in solution-processable semiconductors (MACHIRO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-08-01
End date: 2031-07-31
Duration (months): 60.0
Total project cost (EUR): 2173060.0
EU funding (EUR): 2173004.0
Participants: 1
Project status: SIGNED

Chiral solution-processable semiconductors are a new class of materials that could revolutionize optoelectronics by enabling circularly polarized light (CPL) emission and spin control without external magnetic fields at room temperature. This could enhance the efficiency of displays, solar cells, holography, cryptography, and biomedical imaging, while opening new possibilities in quantum information processing. However, current trial-and-error approaches, limited by the absence of suitable techniques to probe mechanisms, prevent systematic breakthroughs in designing chiral materials with strong CPL emission and spin polarization. MACHIRO will overcome these limitations. We will develop the first ultrafast broadband magneto-chiroptical microscope to map the Stokes vector of light polarization emitted from chiral materials with diffraction-limited spatial and femtosecond-temporal resolution. This will enable us to directly track the interplay between charge, spin, and light polarization in time and space, to mechanistically understand how CPL and spin polarization arise from structural chirality imprint on the excited state. We will use this new tool to study a range of i) heavy-element containing chiral halide perovskite semiconductors, as well as ii) purely molecular twisted materials with much less spin orbit coupling. We will systematically vary dimensionality (3D bulk to 0D quantum dots), hierarchical level of chirality, helical pitch and addition magnetic impurities, while always monitoring the role of local disorder through mapping. Thus, we will identify dominant loss channels and arrive at a unified mechanism of how light and spin polarization are connected. Finally, we will integrate insights across all materials, establishing universal design rules for using chirality to control spin and light simultaneously, enabling next-generation solution-processable spin-optoelectronic technologies with unprecedented energy efficiency.

Keywords: optoelectronics,chirality,ultrafast spectroscopy,halide perovskites,molecular electronics,chiral materials,ciss
A bio-archaeological study of 1,800 years of resilience and adaptation to urbanity (CityLife)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Greece,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1998250.0
EU funding (EUR): 1998250.0
Participants: 3
Project status: SIGNED

CityLife explores, from a bioarchaeological perspective, how historical populations adapted to an urban environment and developed resilience to the disadvantages of urban life. By exploiting the vast amount of information contained in human skeletal remains, the project will clarify the roles of biological factors in the durability and sustainability of pre-industrial urban societies. Newly developed osteological, chemical isotope, and genomic methods will be used in this project, together with cutting-edge tools for statistical evaluation. CityLife will evaluate the living conditions, economy, population structure, pathogen load, and immune defenses in a sample of more than 4,500 skeletons from a hotspot of European urban culture: Thessaloniki. This city in northern Greece still exists today, and in historic times it formed a bridge between the Roman West and the Byzantine East. Thessaloniki offers the unique constellation to study urban life from 300 BC to AD 1,500 and thus to draw inference about an urban population in a single place continuously over 1,800 years. The main objectives of the project are to a) infer urban living standards by studying secular changes in anthropometric indexes, infant diet, childhood stress, and trauma in a combined manner; b) investigate the resilience and sustainability of urban food systems by reconstructing individual diets and local supply networks; d) investigate social structures, religious cohabitation, and migration by genetically reconstructing the degree of kin and non-kin relationships; and e) explore the effects of pathogen exposure on human evolution and health by studying genes associated with increased immunological response and the oral microbiome. CityLife will examine empirically tangible aspects of biocultural development to answer the simple question of how humans became urban species.

Keywords: biological anthropology,urban history,human evolution,paleodiet,paleogenetics,biological standards of living,population genetics,epidemiology
Expanding Integrated Assessment Modelling: Comprehensive and Comprehensible Science for Sustainable, Co-Created Climate Action (IAM COMPACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Greece,Finland,Denmark,Spain,Belgium,Norway,Italy,Germany,India,China,United States,Ethiopia,Ukraine,Sri Lanka,Kenya,Switzerland,United Kingdom,Sweden
Call: Enhanced integrated assessment in pursuit of global climate goals (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4461325.75
EU funding (EUR): 4461323.0
Participants: 23
Project status: SIGNED

Neither the first round of Nationally Determined Contributions (NDCs) nor currently implemented climate policies are on track to meeting the Paris Agreement’s objectives. Parties are expected to increase their ambition and produce new NDCs covering the post-2030 period. The design of a multi-dimensional set of policy measures that comprise countries’ climate policy agendas is supported by equally diverse integrated assessment modelling (IAM) activities. Notwithstanding the recent progress in the IAM literature and scenario space, the modelling world has fallen short of its promise to include non-scientists in its process; to account for individual choices and lifestyle changes that are indirectly narrated as assumptions not interacting with the vividly modelled technology-economy-environment-policy flows; and to place climate action as a cross-cutting theme in the sustainability spectrum. IAM COMPACT will support the assessment of global climate goals, progress, and feasibility space, as well as the design of the next round of NDCs and policy planning beyond 2030 for major emitters and non-high-income countries. We will use a diverse ensemble of models, tools, and insights from social and political sciences and operations research, and will integrate bodies of knowledge to co-create the research process and enhance transparency, robustness, and policy relevance. We will explore the role of structural changes in major emitting sectors and of political, behaviour, and social aspects in mitigation; quantify factors promoting or hindering climate neutrality; and account for extreme scenarios, to deliver a range of global and national pathways that are environmentally effective, economically viable, politically feasible, and socially desirable. In doing so, we will fully account for COVID-19 impacts and recovery strategies, and align climate action with broader sustainability goals, while developing technical capacity and promoting ownership in non-high-income countries.

Keywords: integrated assessment modelling extremes climate policy ndcs global stocktake paris agreement major emitters non high income countries capacity development open science interdisciplinarity
HOP ON: NaV1.5 regulation fine-tuning as a therapy for cardiac Conduction and Arrhythmic diseases at Risk of suddEn Death (NaV1.5-CARED HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 346051.25
EU funding (EUR): 346051.25
Participants: 2
Project status: CLOSED

The NaV1.5-CARED project aims to decipher the genetic architecture of the Brugada syndrome, identify regulatory regions modulating SCN5A expression level, characterize their role and impact in hIPSC-CMs model, and finally develop novel therapeutics based on SCN5A gene expression modulation. While GWAS on Brugada syndrome highlighted transcription factors and structural coding genes and fibrosis, mild cardiomyopathy, and structural remodeling can be observed in some of Brugada patients, systematic effects resulting from changes of contractility (fibrosis, mild cardiomyopathy, and structural remodeling) need to be investigated. The project aims to enhance mechanistic understanding of the regulatory region identified in the Brugada syndrome GWAS and to be able to propose novel therapeutic strategy. FNUSA ICRC joins the consortium to expand the study by introducing traction force microscopy (TFM) to measure cardiomyocytes contraction forces. Additionally, this method will link mechanical changes with SCN5A regulatory region genetically or molecularly modified NAV1.5 localization using advanced imaging techniques. FNUSA's expertise adds new research capacity, including mechanobiology, TFM, and correlative microscopy. The project will also launch a Brugada syndrome awareness campaign in the Czech Republic, addressing under-recognition of the condition. Open data-sharing and collaboration will ensure the reproducibility and accessibility of the research. FNUSA’s inclusion broadens the project's reach and enhances its interdisciplinary focus. Long-term, the partnership will improve disease understanding and patient outcomes.

Keywords: traction force microscopy cardiomyocyte contractility correlative microscopy mechanobiology