Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Green and digital continuous-flow pharmaceutical manufacturing (GreenDigiPharma)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Spain,Netherlands,Switzerland,Brazil,China,United Kingdom,Saudi Arabia,United States,Slovenia,Belgium
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2605881.6
EU funding (EUR): 2605881.6
Participants: 18
Project status: SIGNED

Greening and digitalizing pharmaceutical manufacturing is one of the grand challenges of Europe's pharma-industry. It offers a significant opportunity to boost productivity, improve competitiveness and reduce the industry large environmental footprint. Current progress is impaired by shortage of trained engineers and scientists, who can design green and digital pharmaceutical processes. This MSCA doctoral network will focus on addressing these skills gaps, delivering a cohort of highly-skilled and trained PhD graduates that will lead the green and digital transformation of the pharmaceutical manufacturing, both in academic and industrial environments. The consortium brings together 7 universities, 1 research center, and additional 11 associated members from academia and industry. This will address urgent topics in continuous green manufacturing and develop greener routes to prepare pharmaceutical products, promoting the adoption of novel technologies (flow synthesis instead batch methods, heterogeneous nano and biocatalysis in lieu of homogeneous catalysts, renewable carbon sources, novel purification methods, digitalization tools) for sustainable manufacturing. Specific PhD topics for 10 ESRs have been outlined. The research and training programme will equip the ESRs with key scientific and transferable skills, such as IPR, entrepreneurship, data and innovation management. The consortium strong track record in the management of interdisciplinary research and training will ensure effective and timely training of the next-generation leaders of Europe’s pharma-industries. The exposure to academic and industry sectors will also provide the researchers with unparalleled career opportunities.

Keywords: flow chemistry,synthetic chemistry,pharmaceutical synthesis,green chemistry,heterogeneous catalysis,crystallization,chromatography,biomass conversion,process intensification,process chemist
[n]Helicene Diimides: A Twist in Diimide Chemistry (HELIMIDE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-08-01
End date: 2028-01-31
Duration (months): 66.0
Total project cost (EUR): 1499686.0
EU funding (EUR): 1499686.0
Participants: 2
Project status: SIGNED

The introduction of chirality in conjugated organic compounds gives rise to properties such as absorption and emission of circularly polarized light, spin-selective charge-transport, and magneto-chiral anisotropy, which enable conceptualization of new functions. Therefore, chiral organic semiconductors (OSCs), which utilize both charge and spin of the carriers, are needed as new materials to drive the development of next-generation (opto)electronics such as spin-LEDs, 3D displays, and quantum-based optical computing. While the field of OSCs has matured, there is an urgent need for chiral OSCs, which can offer high charge-carrier mobilities along with the strong chiroptical response to transform the laboratory-based proof-of-concept research on chiral OSCs into real-world applications. The objective of the proposed research is to develop chiral OSC materials, which will exhibit (i) effective chiroptical responses, (ii) high fluorescence quantum yields, and (iii) dynamic spin-selective charge-transport. To achieve this goal, I plan to develop a new class of functional chiral molecules, namely, [n]helicene diimides ([n]HDI), where two six-membered imide moieties are spanned by an [n]helicene spacer. The proposed research bridges two well-established research fields: (i) planar polycyclic aromatic hydrocarbons bearing diimide units, which are excellent semiconductors, and (ii) 3D [n]helicenes, which display strong chiroptical responses. The research plan will capitalize on three synthetic strategies: (1) A small-molecule approach to gain a fundamental understanding of the structure-function relationship, originating from the through-bond and through-space coupling between imide moieties. (2) A multi-helicene approach to expand the application scope by taking control over the electronic energy levels and self-assembly behavior. (3) Macromolecular approach to develop homochiral multifunctional materials employing enantiopure [n]HDIs as molecular synthons.

Keywords: n helicenes,rylene diimides,polycyclic aromatic hydrocarbons,organic semiconductors,chirality,stereoselective synthesis
Teaching science in the Colonial Era: knowledge weaponization and cultural integration from Europe to the Jesuit missions (TESCCO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 4
Project status: SIGNED

The TESCCO project aims at offering a comparative study on the methods for teaching science implemented by the Jesuits at the end of the 17th century during their missions in China and North America, to show that the harmonization between religious motives and motives connected to cultural dissemination found in their activities couldn’t have been possible without a serious and wider philosophical reassessment of the role of science and its teaching throughout Europe. This study will cast a new light on the domination strategies adopted during the Colonial Era, connecting consistently for the first time the scientific developments of the early modern period with the many attempts of subjugation and cultural appropriation made at that time on behalf of a (supposed) superior and exclusive knowledge. The interdisciplinarity of this project, which combines the history of science and science teaching, history of philosophy, and sociology is further complemented by a theoretical part that aims at rising awareness of the overlooked connection between the foundation of science and how it is taught to others. By promoting a healthy distinction between raw scientific data and the historical context in which it has been collected, the TESCCO project has the ambition of becoming relevant nowadays as a starting point for a discussion on the role of science as a by-product of the European culture and on how this assumption is seen in the exchanges with other cultures. This project, hosted by Ca' Foscari University of Venice and by the Department of Philosophy at Harvard University, will be crucial to expanding my knowledge and my expertise as a researcher, thanks to the collaboration with my supervisors and the exchange with other researchers involved in ground-breaking projects on early modern science. It will also be a fundamental step in the development of my career, helping me obtain a permanent position at Ca' Foscari University or another European institution.

Keywords: history of mathematics,history of education,social and cultural history,cultural exchanges
From waste to resource: Training young researchers on developing innovative, circular solutions for waste sludge (INCLUE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands,Portugal,Sweden,United Kingdom,France,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2940462.51
EU funding (EUR): 2701720.8
Participants: 17
Project status: SIGNED

Using waste as a resource is the way forward to realize a full circular and sustainable society. One of the most predominant waste streams in Europe concerns wastewater treatment sludge, with a total annual production surpassing 13 million tons. Sludge typically contains a diverse range of recalcitrant and potential hazardous contaminants such as PFAS, endocrine disruptors, pathogens and heavy metals, which necessitates the use of efficient & sustainable treatment strategies. Because of these hazardous substances, the beneficial use of sludge is currently limited with no adequate overall solutions. INCLUE responds to this opportunity by developing novel sludge treatment routes, generating the required insights to allow an optimisation of the current routes, assessing the effects of sludge application, and most importantly, training high-skilled experts in the rapidly expanding field of handling waste as a resource for renewable chemicals, materials and fuels. The main R&D emphasis of INCLUE lies indeed on developing innovative technological advances that combine the elimination of the increasingly present contaminants in sludge with a maximum resource recovery. Ten creative and entrepreneurial-minded DCs will be trained via an international, intersectoral and interdisciplinary research training program, pushed by a broad consortium of 6 academic and 11 industrial organisations. The highly relevant field, combined with an advanced training program that encompasses transversal skills and training through research will ensure that highly trained professionals will enter the job market, further strengthening the competitiveness of the EU in this domain.

Keywords: resource recovery,sludge pre treatment,pollutant removal,biochemical conversion,volatile fatty acids production,bio energy generation,ecotoxicity,bioassays,biosensors
nanoVAST: a novel, non- viral LNP for precision payload delivery of genome editors and other cargo (nanoVAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-10-01
End date: 2024-03-31
Duration (months): 18.0
Total project cost (EUR): 184285.71
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Cell-specific cargo delivery is a key remaining problem in the field of RNA-based therapeutics. Thus far, delivery has relied on lipid nanoparticles (LNPs) which encapsulate RNA with high efficiency, but broadly lack in specificity. Viral vectors are currently the only FDA approved tissue-specific cargo delivery option, with specificity being the result of manipulation of outer capsid proteins. However, viral systems are also associated with drawbacks such as oncogenicity, antigenicity and pre-existing immunity to the viral carrier itself. The ideal carrier system would involve LNP-efficient cargo encapsulation together with specific targeting in the absence of oncogenicity or immunogenicity. DKFZ and Panosome GmbH have together developed this exact particle – the nanoVAST: a patented vesicular phospholipid bilayer densely decorated with a single protein that can be fused to a targeting molecule of interest through specific, efficient, and separately patented chemistry. Importantly, the attachment of the targeting component relies on a coupling of the vesicle to the targeting moiety, rather than a genetic manipulation of the carrier itself (as is the case with viral vectors), giving this system an unparalleled level of versatility. Additionally, our vesicular system is inherently fusogenic with target membranes, thus permitting cargo delivery directly to the cytoplasm and avoiding the reliance on the incredibly inefficient “endosomal escape” mechanism that plagues LNPs (it is estimated that conventional LNPs only deliver approximately 1% or less of their payload into the cytoplasm). This ERC PoC proposes to use the nanoVAST particle to (a) deliver specific RNA cargo to CD19+ B cells; (b) transport within the cells this cargo to the endogenous RNA editing machinery and (c) functionally alter the surface of the targeted cells. Through the PoC we aim to accelerate nanoVAST, our precision payload delivery system, towards direct clinical applications.
AI-ASsisted cybersecurity platform empowering SMEs to defend against adversarial AI attacks (AIAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Romania,Spain,Bulgaria,Cyprus,Italy,Portugal
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 1836057.14
EU funding (EUR): 1564000.0
Participants: 10
Project status: SIGNED

In recent years, the digital environment and digital transformation of enterprises of all sizes have made AI-based solutions vital to mission-critical. AI-based systems are used in every technical field, including smart cities, self-driving cars, autonomous ships, 5G/6G, and next-generation intrusion detection systems. The industry's significant exploitation of AI systems exposes early adopters to undiscovered vulnerabilities such as data corruption, model theft, and adversarial samples because of their lack of tactical and strategic capabilities to defend, identify, and respond to attacks on their AI-based systems. Adversaries have created a new attack surface to exploit AI-system vulnerabilities, targeting Machine Learning (ML) and Deep Learning (DL) systems to impair their functionality and performance. Adversarial AI is a new threat that might have serious effects in crucial areas like finance and healthcare, where AI is widely used. AIAS project aims to perform in-depth research on adversarial AI to design and develop an innovative AI-based security platform for the protection of AI systems and AI-based operations of organisations, relying on Adversarial AI defence methods (e.g., adversarial training, adversarial AI attack detection), deception mechanisms (e.g., high-interaction honeypots, digital twins, virtual personas) as well as on explainable AI solutions (XAI) that empower security teams to materialise the concept of “AI for Cybersecurity” (i.e., AI/ML-based tools to enhance the detection performance, defence and respond to attacks) and “Cybersecurity for AI” (i.e., protection of AI systems against adversarial AI attacks).

Keywords: cybersecurity,artificial intelligence,adversarial ai,digital twins,data analytics,cyberattack detection
Very High Energy Electrons Beam for Radiotherapy (ebeam4therapy)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel,Malta
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-08-01
End date: 2026-01-31
Duration (months): 42.0
Total project cost (EUR): 2477043.75
EU funding (EUR): 2477043.0
Participants: 2
Project status: SIGNED

Despite advanced treatment planning and delivery, conventional oncologic radiotherapy (RT) is limited by acute toxicity and long-term side effects caused by radiation delivery to healthy tissues, which often restricts the ability to deliver a sufficient dose of radiation to the tumours. The problem is exacerbated when treating cancers that are either deep down inside the human body, or in delicate areas where toxicity to nearby organs could cause serious side effects, especially when treating obese patients, whose numbers are increasing globally. Thus, an accessible and cost-effective alternative to current RT modalities is urgently needed. In ERC-PoC project Vherapy we made a breakthrough in demonstrating the viability of delivering high-quality particle beams with compact laser plasma accelerators for very high energy electron radiotherapy (VHEE-RT). We demonstrated that such a VHEE beam can be produced with a single laser beam using a new injection scheme, making the acceleration machinery small, simple and cost effective, thereby giving this device of the future substantial competitive advantage. The objectives of the eBeam4Therapy project are to optimize VHEE beam performances for radiotherapy applications further, to characterise the 3D dose deposition, to improve and scale-down each component of the machine, and finally to build a machine prototype that demonstrates the technical feasibility in an economically competitive setting. The commercial feasibility is validated with real market players and the project expands the existing network of collaborators and sources additional investment to accomplish the next steps in technological & commercial development to speed up market entry. eBeam4Therapy aims to revolutionise cancer therapy by providing better clinical outcomes and radically improving the quality of life of cancer patients at a lower financial burden to payers and economies, thus addressing a real and immediate global societal challenge.

Keywords: radiotherapy laser plasma accelerator very high energy electrons,medical equipment deep tissue tumours cancer therapy
2D materials enabled Wide spectrum image sensors and optical NEURAL network based low power consumption computer VISION (2DNEURALVISION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Belgium,Portugal
Call: New generation of advanced electronic and photonic 2D materials-based devices, systems and sensors (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 5497956.5
EU funding (EUR): 5497956.5
Participants: 8
Project status: SIGNED

From the late 1950s, Computer Vision (CV), a significant field of artificial intelligence (AI), began to be the tool to realize human intelligence and perception. Today, the global computer vision market has a value of over $11 billion and will reach $19 billion in 2027. Current computer vision systems suffer from high power consumption and limited reliability due to the low amount of information captured and sensor malfunction in adverse conditions such as fog, darkness, and bright sunlight. The 2DNEURALVISION project aims to develop the enabling photonic and electronic integrated circuit components for a novel low-power consumption, any weather, any light computer vision system. These components are a 2DM enhanced wide-spectrum image sensor and optical neural network with enabling 2DM components. Non-toxic materials and new waferscale, CMOS-compatible back-end-of-line integration processes for 2DMs will be developed to show compatibility with high-volume markets. The developments in the 2DNEURALVISION project will result in reliable (any weather, any light), low cost (1000x lower), low power consumption (30x lower), and small form factor (1000x lower) computer vision systems. This will have enormous societal impacts by enabling disruptive improvements in the automotive, AR/VR, service robotic, and mobile device sectors.

Keywords: graphene,computer vision,low power consumption,optical neural network,complementary metal oxide semiconductor,colloidal quantum dots,2d materials,photonic integrated circuit,image sensor,ai
Making a choice for life – Cellular and molecular basis of coral larvae settlement and metamorphosis. (EnvIronchannel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Corals form the basis for some of the most diverse marine ecosystems on the planet. Yet these unique ecosystems have suffered tremendous harm due to anthropogenic influences and are predicted to be among the most adversely affected habitats under the foreseen changes in climate. Among these changing conditions are the occurrence and composition of microorganisms in the coral’s habitat, which are affected by changes in temperature and pH. Corals associate with several specific microorganisms, that govern central aspects of their complex lifecycle, such as the recruitment of larvae, a process that ensures health and resilience of coral reefs. While the central role of biofilms is established in tropical coral species, the vast deep-sea cold-water coral species are less well studied. Lophelia Pertusa is a framework-forming cold-water coral with a global distribution and important ecosystem function -however whether larval recruitment depends on biofilm abundance and composition is unknown. It is therefore urgently required to study this fundamental process in cold-water species to assess and mitigate environmental threats to this unique ecosystem. The proposed study will pioneer investigations into the mechanistic basis of cellular and molecular signal recognition in cold-water coral larvae, taking advantage of the specialized settlement behavior and recent advances in sequencing technology. Here, I will use an interdisciplinary approach, at the border of bacterial recognition, development and sensory biology. I will combine the power of single cell patch clamp electrophysiology, behavioral- and molecular analysis to address central questions about sensory biology in cold-water corals and thereby, the project will produce fundamental knowledge about coral habitat selection that are urgently required to understand which impact environmental changes have on this central process.

Keywords: chemotactile sensation,receptor proteins,development,signal integration,environment