Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Legal rights and the political economy of debt and austerity in Europe (JUSECON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-01
End date: 2018-07-31
Duration (months): 12.0
Total project cost (EUR): 86238.6
EU funding (EUR): 86238.6
Participants: 1
Project status: CLOSED

This research project will explore the Greek debt and austerity crisis to consider what it discloses about the influence of European political economy on the principles and practices of legal rights, and with what implications. The term ‘legal rights’ in this work includes human rights as well as the international rights of states and these respective approaches underpin the two component parts of this study. This is a multidisciplinary study that assumes the validity of law as a means of advancing the cause of justice, but recognises that it is shaped in important ways by other dominant narratives. This study is an exploration of that clash of narratives and its effects on justice in Europe. The first part of this research project is animated by the idea of ‘social rights as fiscal risks’, an idea that finds expression in the latest Memorandum of Understanding (MoU) of August 2015 between the international creditors and Greece. In exploring the means through which human rights safeguards are being made to disappear under fiscal targets, a case study on the influence of austerity reasoning on what constitutes the public interest as a human rights concept will form part of the first section of the project. The second part of this research project will explore the legality of the bailout agreement when measured against the principle of economic self-determination. A preliminary review of the same MoU would seem to offend any reasonable form of economic self-determination, a principle with a long pedigree in international law and demands by states of sovereignty over their economic affairs. Taken together, the two studies will expose ways in which rights are being shaped by the intellectual justifications, logic and practice of economic and financial policy as played out under the European crisis of debt and austerity.

Keywords: international human rights law,public international law,social rights,economic self determination,greece,europe,austerity,debt,economics and finance
FLEXOLIGHTING (FLEXOLIGHTING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies
Action type: Research and Innovation actions
Countries involved: Germany,Finland,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Development of novel materials and systems for OLED lighting (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-03-31
Duration (months): 39.0
Total project cost (EUR): 4358983.5
EU funding (EUR): 4358983.5
Participants: 9
Project status: CLOSED

The flexolighting programme is focussed on research and innovations on materials, processes and device technology for OLED lighting with the intention of building a supply chain within Europe. The aim is to realise OLED devices over a large area/surface with high brightness, high uniformity and long life time. A demonstrator will be built and delivered at the end of the project. The main targets are (i). Cost of the lighting panels should be less than Euro 1 per 100 lumens. (II). high luminous efficiency, in excess of 100 lm/W with improved out-coupling efficiency. (ii). white light life-time of at least 1000 hours at 97% of the original luminance of 5000 cdm-2.(iii). The materials and the devices therefrom will allow for differential aging of the colours, thus maintaining the same colour co-ordinates and CRI over its use. (iv). Attention will be paid to recyclability and environmental impact of the materials and the OLED lighting systems. Flexolighting project will also ensure European industrial leadership in lighting. The introduction of OLED Lighting technology is held back by the current cost of the systems, life-time and poor uniformity of luminance on large area panels. The programme aims to combine existing state of the art OLED materials technology (Thermally activated fluorescent materials (TADF) and phosphorescent emitters and world class transport materials) with new developments in processing technologies (Organic Vapour Phase Deposition (OVPD) and printing technologies) to develop new next of generation low cost OLED lighting systems to move forward to scale up and full scale production on novel planarized flexible steel substrates with cost effective conformal encapsulation method. The transparent top contacts made of thin metallic films, conducting polymers or graphene monolayer with metal tracks to reduce the series resistance will be employed in inverted top emitting OLED structures to deliver 100 lumens per Euro.

Keywords: large area,large uniformity,flexible,conformable oleds for lighting
Quality-Aware Rapid Software Development (Q-RAPIDS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Finland,Finland,Poland,France
Call: Software Technologies (H2020-ICT-2016-1, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 4997590.0
EU funding (EUR): 4997590.0
Participants: 8
Project status: CLOSED

Context. Software quality is an essential competitive factor for the success of IT companies nowadays. Recent technological breakthroughs such as cloud technologies, the emergence of IoT and technologies such as 5¬G, pose demanding quality challenges in software development. Problem. Optimal software quality asks for the appropriate integration of quality requirements (QRs) in the software life-cycle.However, software development methodologies still provide limited support to QR management which is utterly important in rapid software development processes (RSDP): faster and more frequent release cycles should not compromise software quality. Concept. Q-Rapids defines an empirical-based, data-driven quality-aware rapid software development methodology. QRs are incrementally elicited and refined based on data gathered both during development and at runtime. This data is elaborated into quality-related key indicators presented to decision makers through a strategic dashboard with advanced capabilities. Selected QRs are integrated with functional requirements for their unified treatment in the RSDP. Outcome. A TRL7 validated Q-Rapids framework, including cutting-edge tools and methods to smartly manage QRs along with functional requirements in a similar rapid and holistic manner. Impact. Increase of software quality levels through continuous data gathering and analysis. Significant productivity increase to the software life-cycle by means of smooth and tool-supported integration of QRs in the RSDP. Shorter time to market due to reduction of quality-related maintenance efforts and more informed decision making in the planning of release cycles. Impact will be measured through 11 project indicators with defined target values. Consortium. 3 research organisations,1 SME, 2 mid-caps and 1 corporative with balanced geographical distribution. The consortium combines long research tradition in software development and cutting-edge technological knowhow in versatile ICT sectors

Keywords: quality requirements,non functional requirements,rapid software development processes
Function of DUX4 in skeletal muscle and non-muscle tissues (DUX4)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-09-29
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Somatic expression of the retrogene DUX4 in skeletal muscle is associated with the development of the common myopathy facioscapulohumeral muscular dystrophy (FSHD). As FSHD patients mainly present with muscular symptoms, research in the FSHD field has focused on unraveling the functional consequences of DUX4 expression in skeletal muscle. Research on DUX4 expression in non-muscle tissues is limited, but increasing evidence suggests a biological function for DUX4 in somatic tissues. I aim to characterize DUX4 expression in non-muscle tissues, to determine the genome-wide transcriptional consequences of DUX4 expression, to identify DUX4 target genes in these tissues, and to establish whether treatment with DUX4 antisense oligonucleotides negatively impacts somatic tissues in which DUX4 has a biological function. First, I will use a combination of quantitative reverse transcriptase PCR, immunofluorescence staining, and flow cytometry to establish which tissues and what cell types express DUX4 in human and mouse. Next, I will use the innovative technique of single-cell RNA sequencing to determine the autonomous and non-autonomous functional consequences of DUX4 expression in DUX4-positive tissues. In parallel, to establish which genes and pathways are direct targets of DUX4 and whether tissue-specific differences exist, I will employ DUX4-chromatin immunoprecipitation sequencing. Finally, I will determine the effect of DUX4 suppression in vitro and in vivo. The proposed work will provide in depth analysis into the biological function of DUX4 in somatic tissues, contribute to the long-standing enigma in the field why FSHD presents as a muscle-specific disease, and provide guidance to DUX4-targeted therapies that are currently being developed.

Keywords: dux4,facioscapulohumeral muscular dystrophy
HIGHLY FLEXIBLE, HIGHLY THERMAL CONDUCTIING CERAMIC NANOFIBER COMPOSITES FOR PRINTED CIRCUIT BOARD APPLICATIONS (Flexiramics)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FLEXIRAMICS® is light and flexible like paper but 100% ceramic and has a low cost for a ceramic; it is calculated that Flexiramics® will costs 30€/m2 at production level whereas ceramic sheets costs tens of hundreds of euros. Its unique properties open new doors for the development of next generation products limited by traditionally available materials. Flexiramics® has numerous benefits over current ceramics, in particular that it behaves like paper and can be bent and shaped into any position, and that it is not brittle. Therefore it can be used in many harsh environments without the limitations of currently available to ceramics and also providing unique thermal, electrical, catalytic and filtering characteristics. Flexiramics® has been developed as a novel functional 100% ceramic nanofibers mat. It consists of a non-woven matrix of ceramic nanofibers, which enhances its flexibility. Furthermore, when combined with a polymer (up to 50% ceramic loading), we obtain a High Performance Film where plastic properties are improved. Will Flexiramics Change Circuit Boards Forever? Current flex PCBs are fabricated on top of polymer substrates, which have a very low thermal conductivity. Chips and electronic components generate heat; when a substrate with low thermal conductivity is used, the chip get hotter, lose efficiency and malfunction. Flexiramics® PCBs can achieve a significant improvement in thermal conductivity, which would be beneficial for power electronics and telecommunications. We strategically chose to work on the polymer-ceramic composite market as it is a fast-growing market and Flexiramics® can break the limitation of the ceramic loading. We choose to make Flexiramics®-PI due to the large usage of this polymer in the fields of flexible displays and PCBs.

Keywords: polymers,ceramic,electronic,materials
Super-sensitive detection of Alzheimer’s disease biomarkers in plasma by an innovative droplet split-and-stack approach (SensApp)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,Belgium,Finland,Finland
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 3287562.5
EU funding (EUR): 3287562.5
Participants: 6
Project status: CLOSED

The detection of biomarkers in body fluids is of great importance for disease early diagnosis. The clinical practice uses typically immunoassay methods (e.g. ELISA, Enzyme-Linked Immuno Sorbent Assay, and related techniques) for biomarker determination. Unfortunately, these techniques fail dramatically in a wide variety of cases where the concentration of biomarkers falls below the limit of detection (LOD). The Alzheimer’s disease (AD) is one real example. Nowadays the AD diagnosis from blood collection is not possible just for the above-mentioned reason. The AD biomarkers are low abundant in blood and they can be determined only in cerebrospinal fluid (CSF), thus requiring a highly invasive intervention on the patient (lumbar puncture) under hospitalization, causing also high costs for the public health. SensApp seeks to develop a bench-top “super-sensor” able to determine low abundant AD biomarkers simply in plasma, from peripheral blood, for very early and non-invasive diagnosis in routine clinical practice. We will develop an outstanding innovative technology that we call droplet split-and-stack (DSS), able to stack the biomarker molecules in sub-microlitre volumes on a solid support before the immunoreactions, thus avoiding diffusion limits and improving significantly the LOD. The super-sensor will be fully automated and cost-effective. An integrated micro-system in polar materials will split the mother drop of the plasma sample in tiny droplets through electric fields and will accumulate them on a microscale site, while an innovative integrated optical system will detect the fluorescence signal directly on the reaction support. SensApp will lay the foundations for a future European industrial leadership involved in all of those clinical studies where the detection of low abundant biomarkers is of vital importance for the welfare of society.

Keywords: biosensors,pyroelectric effect,electrohydrodynamics,immunoassay,nano optics,photonics,microfluidics,micro optical detection
Derived categories, stability conditions and geometric applications (SCGA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Geometry studies higher-dimensional curved spaces. We can describe these spaces by equations, but the only case where we have any hope to use them for calculation is when the equations are polynomials. The resulting spaces are the objects of algebraic geometry, which are called varieties. Although these objects have been studied for a long time, there are still lots of crucial open problems: If we are given a variety, can we embed it in other well-known varieties? For instance, can we find a ''nice'' surface which contains a given curve? If yes, how many such surfaces exist, and can we characterise them via some of the geometrical properties of the curve? The geometric information of varieties can be encoded in algebraic objects, known as derived categories. Inspired by ideas in string theory, Bridgeland introduced the notion of stability conditions on derived categories. This topic has been highly studied due to its connections to various fields in mathematics and physics, and lots of ideas and techniques have been developed in the area. Now is the time to employ the whole spectrum of modern tools in derived categories and stability conditions to solve so far intractable geometrical problems. My recent work proves that deformation of stability conditions and varying stability status of an object (wall-crossing phenomenon) are powerful new techniques for solving long-standing geometrical problems, that do not appear to involve derived categories. Surprisingly, stability conditions and wall-crossing truly provide the right context for studying those problems. The main goal of this research programme is to draw upon ideas and tools in algebra, geometry and mathematical physics to describe some outstanding geometrical problems in terms of derived categories and stability conditions, and then apply wall-crossing techniques to solve those problems.

Keywords: derived categories,stability conditions,algebraic geometry of curves and surfaces,donaldson thomas theory
Multifunctional Personalized Self-Assembled Biomaterials for Bone Regeneration (PersonalBone)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

Bone regeneration is a critical challenge in the treatment of fractures, bone loss due to tumor resection, and alveolar bone deficiencies. Currently, approximately 2.2 million bone graft procedures are performed annually worldwide. Despite significant progress in bone tissue engineering, there is an unmet need for patient-specific long-lasting bone restoration to reproduce the unique physical, chemical, and biological properties of hierarchically structured bone in a personalized manner. While bones can often naturally self-heal, critical-size bone defects lead to a failed repair process. Expanding on the current understanding of bone regeneration, I will integrate the biomechanical and immunological triggers of the healing process into an artificial bio-mimicking scaffold to specifically target critical defects. Thus, I aim to develop a conceptually new approach of personalized layered 3D-printed supramolecular scaffolds. I intend to use a bottom-up multi-component co-assembly to produce tailored, layer-by-layer printed, extracellular-matrix-mimicking scaffolds that not only fit the defect shape, but also mimic the bone composition around the defect. For this purpose, I will significantly expand the repertoire of our proprietary peptide-based hydrogel technology by chemical modifications that allow interaction with bone minerals, slow release of growth factors, and activation of the immune system to trigger healing. I will combine computerized tomography scans and computer-assisted manufacturing to design personalized scaffolds that can be studied in an alveolar bone model, and be customized to accommodate bone type, structure, gender, age, and systemic diseases. PersonalBone aims to develop customized supramolecular scaffolds that will promote personalized therapy for bone regenerative medicine, thus significantly advancing the fields of tissue engineering and materials science while offering a novel solution to a major healthcare issue.

Keywords: tissue engineering,bone regeneration,molecular self assembly,hydrogel scaffolds,co assembly,bionanomaterials,3d printing
ECO-FRIENDLY AND BREAKTHROUGH MITE TREATMENT FOR HONEY BEES (VATOREX)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Switzerland
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 2684632.5
EU funding (EUR): 1642975.25
Participants: 1
Project status: SIGNED

Currently, honeybee mortality rates range from 5% to almost 30% depending on the country and the year, being some of the main causes the Varroa mite. This parasite is currently treated with chemicals, which are considered a necessary evil by a population of beekeepers that considers chemical treatments largely as a threat because themselves are a cause for the bees’ population decline. In view of these problems, other alternatives have been researched for decades, being the hyperthermia the methodology with highest potential to displace the use of chemicals. However, until now the current commercial solutions based on hyperthermia principles are not an alternative to chemical products due to a lower efficiency. Vatorex AG is an award winning Swiss company committed toproviding cost-efficient and eco-friendly solutions for beekeepers. The new business started in 2016 and provides beekeepers with an eco-friendly solution to protect their hives from their greatest enemy: the Varroa mite. We have developed an eco-friendly solution to kill the Varroa mites by using a natural principle of different heat tolerances of bees and varroa. In a range between 39°C - 42°C the parasite dies while the bees survive unharmed. In contrast to other hyperthermia systems, Vatorex Varroa Solution heats the brood combs directly from the inside thanks to a heating coil that acts like a floor-heating. Vatorex Varroa Solution has proven to be an effective treatment directly in the beehive (95% of male mites and nymphs die at 41ºC within 2 hours of treatment). The Vatorex-System means a reduction of sanitary cost of 66% per hive and a 18% in total cost of honey production that entails a total saving impact for the approximately 600,000 European beekeepers and their 17 million of hives. Vatorex is fully aligned with the European policy initiatives in biodiversity and pollinator protection such as European long-term survival strategy or the objectives of the EU Habitat directive.

Keywords: honey bees,varroa mites,beekepers,eco positive treatment,apiculture,chemical free