Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Big-Data Analytics for the Thermal and Electrical Conductivity of Materials from First Principles (TEC1p)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 2048183.0
EU funding (EUR): 2048183.0
Participants: 1
Project status: SIGNED

Thermal conductivity (TC) is a key characteristic of many materials, particularly those used in the energy and environment sectors (thermoelectrics, thermal-barrier coatings, catalysis, etc.). However, TC is largely unknown − of the 225,000 identified inorganic semiconductor and insulator crystals, only 100 have any TC data available. By combining a novel ab initio molecular dynamics TC theory and big-data analytics (machine learning, compressed sensing, subgroup discovery), we will generate quantitative values and understanding of TC (and electrical conductivity (EC)) for most of these 225,000 materials, as well as for materials not yet discovered. TEC1p will develop and deploy five key approaches. Individually these are already novel for materials science, but their combination in TEC1p enables a true breakthrough. These five components are: 1) Ab initio theory of TC 3 (advanced density-functional theory, seamlessly linked to size- and time-converged statistical mechanics). 2) Ab initio theory of EC (advanced …; see #1). 3) Compressed sensing to identify a set of physical parameters that describe the TC and EC behaviour and to derive predictive equations that work for all materials.5 4) Active learning to build a systematic big-data database of materials, their TCs and ECs. 5) Subgroup discovery to recognise trends and anomalies in the big data, enhance the active learning, and elucidate the underlying physical mechanisms. In analogy to Mendeleev’s table of the elements, we will build maps that arrange existing and predicted materials according to their TC and EC properties. The methods that we will develop and the extensive calculations that we will execute are both innovative and timely. They will greatly progress scientific knowledge of the physical properties of materials. The impact of the concepts, methodology, and results will be far reaching for materials science, novel materials discovery, engineering,

Keywords: ab initio molecular dynamics,compressed sensing,machine learning,density functional theory and beyond
The learning of prehistory of knapping stone (PREKARN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The aim of this study is to identify the mechanics of cultural transmission among Pleistocene human groups and to provide new ideas for the investigation of occupational dynamics through lithic technological approach. Social learning informs us of the cognitive abilities to acquire knowledge transmitted between generations as adaptive strategies. In the archaeological record, the transmission of knowledge and the skills are identified through repetitive patterns, but most of them only remain in the best preserved archaeological material: the lithic tools that hominins made to survive. This project aims to ascertain how hominins learnt through the study of the size of the lithic tools (since novices knappers tend to prouce more small flakes that experienced knappers), and the management and know-how or “savoir-faire” of the knappers preserved into the archaeological collections. This will provide more information about the cognitive evolution of our ancestors. My goal is to study these mechanisms on the basis of two sections: The first part will consist in developing an experimental project to define morphotechnological characters that are crucial to learn the "appropriate" size of the tools to made . The second part will be dedicated to track these morphotechnological characters in the archaeological record through an inter-disciplinary study, including technology, spatial and refitting analyses. The data obtained from these analyses will be processed jointly using a multivariate statistical analysis in order to identify technological patterns. These patterns differ between levels and sites, suggesting the possible existence of cultural identities or behavioural predispositions according to each human group. The integrated analysis of these different and complementary aspects guarantees the interdisciplinary and the innovative nature of the project, since this kind of research has never been conducted before at this level.

Keywords: paleolithic,lithic technology,cognition,stone knapping,human evolution
Structural and functional characterization of MAVS-DDX3-vRNA complex (MDR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

The mitochondrial antiviral signalling (MAVS) adaptor protein is a central signalling hub for host cells to mount an antiviral response following RNA virus infections, which is initiated by the cytosolic receptors that trigger the type-I interferon (INFs) path through the MAVS. Recently, it has been shown that the RNA helicase DDX3 is a novel atypical member of the viral cytosolic receptor pool and it is required to activate the MAVS during the antiviral response. In fact, DDX3 is crucial in the translation initiation of the HIV-1 RNA and it is identified as viral RNA sensor able to induce the antiviral immunity in dendritic cells (DCs). DDX3 binds to viral RNAs lacking the poly(A) tails, also known as abortive transcripts, and then associates with the MAVS to trigger the production of type I IFN. Currently, it is unknown how the complex partners MAVS-DDX3-vRNA (MDR) interact for assembly and what is the MDR mechanism of action at molecular level. The proposed research will be focused on the structural and functional characterization of the MDR complex by biophysical and cellular biology techniques. Notably, silencing DDX3 or MAVS expression suppress DC activation in response to HIV-1 infection, an event that in physiological condition is at the front line of host defence against the HIV-1. Therefore, the central role in triggering antiviral immune response makes MDR a strategic pharmacological target. However, addressing this task requires the MDR structure elucidation in order to exploit its molecular features to create a new generation of adjuvants in anti-retroviral therapy. This research provides an understanding of how cellular protein sensors interact with retroviral RNA to trigger the native immune response and induce expression of antiviral proteins.

Keywords: molecular immunology
Grow your manufacturing business (Better Factory)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Germany,Italy,Cyprus,Bulgaria,Poland,Romania,Switzerland,Finland,Finland,Hungary,Slovakia,Slovenia,Belgium,Poland,Finland,Greece,Greece,Latvia,Czechia,Netherlands,Netherlands,Luxembourg,Portugal
Call: I4MS (phase 4) - uptake of digital game changers (H2020-DT-2019-2, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 8641592.36
EU funding (EUR): 8000000.63
Participants: 30
Project status: SIGNED

Better Factory will provide methodology for Manufacturing SMEs to collaborate with Artists to develop new and personalized products. At the same time Better Factory will provide technology for SMEs to become fully connected cyber-physical-systems, transforming them into Lean-Agile production facilities capable of manufacturing new and personalized products alongside existing products. Main results: - An Advance Production Planning and Scheduling (APPS) system which can be deployed on a free and open IoT platform at 10% of the cost in 50% less time. APPS will automatically reconfigure the collaborative robots considering the individuality and gender of worker, and will also reduce 10% assets, 25% area, 30% resources, 35% logistics, 40% machines and tools and workplaces, resulting in 13% cost reduction, 15% production increase and 30% time to market. - A Marketplace, a one-stop-shop, where Manufacturing SMEs can buy services from Technology suppliers, Artists, CCs, training providers and financial brokers. - A portfolio of 16 cross-border Application Experiments by 48 SMEs selected through 2 competitive Open Calls, that will test APPS, SME+Artis collaboration and other services, and leveraging 11M€ of public and private funding becoming success stories. - Services, including Technical, Business and Art mentors, infrastructure, training and access to finance. Better Factory network consists of 28 members. 18 DIHs (10 CCs, 8 industry associations), 6 Technology suppliers and 4 service providers for marketing, access to finance, FSTP management and legal framework. Partners are currently engaged in I4MS-Go, DIH², HORSE, L4MS, MIDIH, AMABLE, BOWI, SHOP4CF. Better Factory covers 16 EU countries, 17 regions with 10 of them from EU-13. Better Factory will demonstrate that public funded research can help manufacturing SMEs & Mid-Caps achieve digital excellence and global competitiveness through Lean-Agile production for the manufacturing of new and personalized products.
Multidisciplinary Approach to Plan Smart Specialisation Strategies for Local Economic Development (MAPS-LED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy,Italy,Finland,United States,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 1512000.0
EU funding (EUR): 1512000.0
Participants: 6
Project status: CLOSED

The joint Exchange programme is based on a research proposal finalized to examine how smart specialization strategies (S3) to regenerate local economic areas can be implemented, according to the new agenda of Europe 2020. This can be largely achieved by incorporating a place-based dimension. The main aim is to identify and prescribe the implementation S3 in terms of spatial, social and environmental factors. The programme will map out local needs and opportunities in a variety of contexts which could drive regional policy interventions. The resulting S3 will not only emphasize “Key Enable Technologies”, but will also empower the local innovation process. Elements gained from the preceding CLUDs project such as tacit knowledge, embedded social networks, and innovative milieu will ensure that the proposed S3 for each area is successful. The proposal intends to apply a Multidisciplinary Approach to Plan Smart Specialization Strategies in a prospective to enhance Local Economic Development (MAPS-LED). The MAPS-LED place-based framework will include two important drivers: 1. Cluster policy, 2. Innovative milieu in terms of the local value chains based on the urban-rural linkages The MAPS-LED project will be built in order to connect three important key-factors: Governance; Localization; Territorial network. The S3 in a MAPS-LED perspective will be visualized through appropriate “designated areas”, overcoming the constraints determined by the locally-bounded concept of the “district” through the rationale of the networks and flows activated by governance dynamics. The proposal exploits and moves forward the findings of the CLUDs project (research network of four EU and two US universities) funded by IRSES 2010, by expanding the concept of social and environmental added value embedded in some innovative urban regeneration approaches to the larger regional context. The result will be to build on the strong existing CLUDs research network and its Int'l Doctorate URED.

Keywords: cluster policy,smart specialisation,spatial indicators,mapping smart specialisation
The Global as Artefact: Understanding the Patterns of Global Political History Through an Anthropology of Knowledge -- The Case of Agriculture in Four Global Systems from the Neolithic to the Present (ARTEFACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1428165.0
EU funding (EUR): 1345996.47
Participants: 2
Project status: SIGNED

Knowledge is an anthropological constant that is indissociable from the birth and interactions of human societies, but is at best a secondary concern for scholars of international relations and globalization. Contemporary global studies are thus unable to account for the co-constitution of knowledge and politics at a macro-scale, and remain especially blind to the historical patterns of epistemic development that operate at the level of the species as a whole and have shaped its global political history in specific, path-dependent ways up to now. ARTEFACT is the first project to pursue a knowledge-centered investigation of global politics. It is uniquely grounded in an anthropological approach that treats globalization and human knowledges beyond their modern manifestations, from the longue-durée perspective of our species’ social history. 'The global as artefact' is more than a metaphor. It reflects the premise that human collectives 'make' the political world not merely through ideas, language, or norms, but primordially through the material infrastructures, solutions, objects, practices, and skills they develop in response to evolving structural challenges. ARTEFACT takes agriculture as an exemplary and especially timely case-study to illuminate the entangled global histories of knowledge and politics, analyzing and comparing four increasingly inclusive 'global political systems' of the Ancient, Medieval, Modern, and Contemporary eras and their associated agrarian socio-epistemic revolutions. ARTEFACT ultimately aims to 1) develop an original theory of the global, 2) launch Global Knowledge Studies as a new cross-disciplinary domain of systematic empirical and theoretical study, and 3) push the respective boundaries of the anthropology of knowledge, global history, and international theory beyond the state-of-the-art and toward a holistic understanding that can illuminate how past trends of socio-epistemic evolution might shape future paths of global life.

Keywords: history of agriculture,globalization
Integrated offshore cultivation of high value seaweed and their potential use in controlling harmful algal blooms. (IntegraSea)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

IntegraSea is in line with the EU Blue Growth Agenda, in seeking to develop and evaluate new opportunities for sustainable aquaculture development. The increasing interest in the incorporation of seaweed-based extracts into ‘natural’ products has created a new market for seaweed. While strong competition for terrestrial space is a constraint, offshore cultivation is growing fast, and Portugal shows potential for expansion. Furthermore, the need to comply with environmental standards is directing fish producers to consider Integrated Multi-Trophic Aquaculture (IMTA) systems where seaweeds are integrated as a valuable crop and as waste bioprocessing means. Another potential advantage of large scale cultivation of seaweed is its integration with bivalve production. Several seaweed species have demonstrated allelopathy potential, inhibiting the growth of Harmful Microalgae which often lead to prolonged closures of bivalve production in Portugal, and across the EU. This project will focus on an innovative holistic approach to offshore cultivation of high value native seaweed species, together with their bioremediation and HABs’ mitigation potential in order to maximise economic and environmental benefits. The work will be carried out between IMPA and CCMAR facilities, two organisations leaders in aquaculture research in Portugal, and where all the conditions for the projects’ successful completion are gathered. Results will be reported in relevant scientific meetings, published in open access peer reviewed international journals, and made accessible to the stakeholders in the aquaculture industry, policy makers and the general public. This fellowship will contribute to the researcher’s career development, by expanding her research and complementary skills, improving the ability of the experienced researcher to attract EU and national research funding in the future.

Keywords: seaweed cultivation,offshore aquaculture,imta,nitrogen removal,biotoxins,shellfish,bivalves,allelopathy,bioremediation
A Non-Surgical Treatment to Restore Heart Valve Function (CVTVT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2022-10-31
Duration (months): 37.0
Total project cost (EUR): 5450186.5
EU funding (EUR): 2494970.0
Participants: 1
Project status: CLOSED

CroíValve is an innovative SME with the mission to lead the treatment of tricuspid valve disease and transform the lives of patients who currently face certain death. In the US and EU, 550,000 patients present with tricuspid valve disease annually. Current treatment involves highly invasive, risky open-heart surgery and <1% receive this due to the risks involved. Recent clinical data is highlighting that the "forgotten tricuspid valve" must be treated. CroíValve has developed a non-invasive device uniquely tailored to the challenges of the tricuspid valve. It is a small device that is delivered through a vein into the right heart, restoring the function of the tricuspid valve. Invented by a leading cardiologist, and refined by expert biomedical engineers, CroíValve’s is a non-surgical, safe, effective, easy to use solution for treating all patients with TR. It will transform patients’ lives, provide physicians a safe and straightforward treatment option and reduce the hospitalisations. There is a significant market potential of > €2.5Bn/year. With H2020 SMEi funding, this Phase 2 Innovation Proposal will support the activities necessary to complete clinical trials and demonstrate safety and efficacy for CE Mark approval. Securing this grant, alongside private funding, will enable the company to expand its manufacturing capabilities, build up its sales and marketing infrastructure. CroíValve’s management team have a successful track record in the development, patenting and commercialisation of medical devices who can position the company as a leader in the treatment of tricuspid valve disease.
Woven and 3D-Printed Thermoelectric Textiles (ThermoTex)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Imagine a world, in which countless embedded microelectronic components continuously monitor our health and allow us to seamlessly interact with our digital environment. One particularly promising platform for the realisation of this concept is based on wearable electronic textiles. In order for this technology to become truly pervasive, a myriad of devices will have to operate autonomously over an extended period of time without the need for additional maintenance, repair or battery replacement. The goal of this research programme is to realise textile-based thermoelectric generators that without additional cost can power built-in electronics by harvesting one of the most ubiquitous energy sources available to us: our body heat. Current thermoelectric technologies rely on toxic inorganic materials that are both expensive to produce and fragile by design, which renders them unsuitable especially for wearable applications. Instead, in this programme we will use polymer semiconductors and nanocomposites. Initially, we will focus on the preparation of materials with a thermoelectric performance significantly beyond the state-of-the-art. Then, we will exploit the ease of shaping polymers into light-weight and flexible articles such as fibres, yarns and fabrics. We will explore both, traditional weaving methods as well as emerging 3D-printing techniques, in order to realise low-cost thermoelectric textiles. Finally, within the scope of this programme we will demonstrate the ability of prototype thermoelectric textiles to harvest a small fraction of the wearer’s body heat under realistic conditions. We will achieve this through integration into clothing to power off-the-shelf sensors for health care and security applications. Eventually, it can be anticipated that the here interrogated thermoelectric design paradigms will be of significant benefit to the European textile and health care sector as well as society in general.

Keywords: organic electronics,thermoelectrics