Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomic predictors and oncogenic drivers in hepatocellular carcinoma (HEPTROMIC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Spain,France,Germany,Italy,United States,Belgium,France,Germany
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2010-11-01
End date: 2014-04-30
Duration (months): 42.0
Total project cost (EUR): 3942896.82
EU funding (EUR): 2999478.0
Participants: 10
Project status: CLOSED

Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy available. The main goal of the HEPTROMIC project is to produce breakthrough knowledge in two critical aspects of HCC research: prognostic prediction and identification of oncogenic drivers susceptible for intervention, leading towards more personalized treatment algorithms. The HEPTROMIC Consortium proposes a 3-year translational research study bringing together an outstanding team of researchers with clinical and genomic expertise along with cutting-edge technology. Eight partners -six academic and two SMEs- will address the following objectives by applying high-end transcriptome, methylome and deep sequencing technology in a large set of 1,140 human samples: Objective 1) Genomic characterization of poor prognosis subclass of hepatocellular carcinoma. Objective 2) Identification of driver oncogenic events as potential treatment targets. Findings obtained will be confirmed in sophisticated experimental models that closely mimics human liver cancer. Objective 3) Design of prognostic devices for clinical translation. This transfer of knowledge will be led by SMEs with entrepreneurial management skills with experience in creating new products increasing European competitiveness and boosting the innovative capacity of industries. Overall, the Consortium foresees impacts on improved patient survival by refining prognosis and decision-making, identifying targets amenable for selective therapies and by improving the allocation of resources. In summary, HEPTROMIC will strength links between the academic and industry spheres, ultimately contributing to reduce liver cancer mortality.

Keywords: liver cancer,hepatocellular carcinoma,translational research,survival,life expectancy,poor prognosis,prognosis prediction,cancer experimental models,genomics,oncogenes,methylation.
Identifying biomarkers of ageing using whole transcriptomic sequencing (EUROBATS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Spain
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-01-01
End date: 2014-06-30
Duration (months): 42.0
Total project cost (EUR): 3920729.81
EU funding (EUR): 2998649.75
Participants: 5
Project status: CLOSED

Ageing is a fundamental biological process that defines all aspects of life, yet the understanding of the basic biological interactions leading to ageing and how genetic and environmental variation contributes to this processes are still largely unknown. We propose to use the most up to date genomic and epidemiological methodologies to shed light in some of the key questions in ageing research. We will use whole transcriptome sequencing, and telomere length assays in three cell types of 855 twins for which a large set of phenotypic measurements relating to ageing are available. These datasets will be integrated with genome-wide association studies in a systems genetics framework to infer causal interactions (genetic or environmental). The combination of these unique datasets together with the expertise of the participants is likely to provide novel insights to ageing research and uncover currently unknown factors that contribute to variation in the ageing process in human populations.

Keywords: ageing,telomere length,transcriptome sequencing,biomarkers,phenotype measurement,genome,twins
Energy Efficiency and Risk Management in Public Buildings (ENRIMA)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Sweden,United Kingdom,Austria,Spain,Belgium,Norway,Spain,Austria,Poland,Spain
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-10-01
End date: 2014-03-31
Duration (months): 42.0
Total project cost (EUR): 3485460.0
EU funding (EUR): 2588585.0
Participants: 10
Project status: CLOSED

The overall objective of EnRiMa is to develop a decision-support system (DSS) for operators of energy-efficient buildings and spaces of public use. By providing integrated management of conflicting goals such as cost minimisation, meeting energy, efficiency, and emission-reduction requirements as well as risk management, the DSS will enable operators to improve building energy efficiency in the most cost-effective manner based on their tolerances for comfort and risk. The DSS will be seamlessly integrated with the existing ICT for controlling each site's energy sub-systems, thereby facilitating the operators’ real-time on-site generation dispatch, off-site energy purchases from diverse sources, and open positions in energy markets. The DSS will also enable long-term planning aimed at increasing energy efficiency, specifically analysis of retrofits and/or expansion of on-site energy sub-systems, in order to meet forthcoming EU targets for reducing CO2 emissions. A laboratory facility in Bizkaia, Spain will serve to test the operation of the DSS, while a community centre in northern Spain and a college campus in Austria will be the venues for the validation exercise. These site tests will enable cost-benefit analyses along with policy lessons for potential users of the DSS via workshops so that they may be able to reduce energy consumption and CO2 emissions by up to 10% in certain cases and improve sub-system integration in line with EU targets. In conjunction with preliminary market analyses and an exploitation plan, the DSS will be ready to make a wide impact at the project’s termination by leading to the opening of a market for ICT-based solutions for buildings.

Keywords: energy efficiency,cost minimisation,co2 reduction,risk management
Highly Customizable and Flexible Packaging Station for mid- to upper sized Electronic Consumer Goods using Industrial Robots (CUSTOMPACKER)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Austria,Austria,Finland,Spain,Germany,Germany
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 3816281.0
EU funding (EUR): 2615000.0
Participants: 7
Project status: CLOSED

The project entitled Highly Customizable and Flexible Packaging Station for mid- to upper sized Electronic Consumer Goods using Industrial Robots (CustomPacker) aims at developing and integrating a scalable and flexible packaging assistant that aids human workers while packaging mid to upper sized and mostly heavy goods.Electronic consumer goods, e.g. TV sets, have a large number of variants and are packaged manually. Only in single-variant production lines with high lot sizes, an automation of the packaging step has been introduced. However, automating the packaging process will decrease the production cycle time and costs also for mixed variant production lines, thus allowing that several production lines can be merged to a reduced number of flexible packaging stations. This also allows an optimization with regard to the actual demands of the (various) goods (i.e. number of items produced per day). In order to achieve the realization of these challenging goals for a highly flexible packaging station, CustomPacker will bring together the highly adaptable skills of a human worker together with the precision and ability of robots to carry heavy goods.The main goal of CustomPacker is to design and assemble a packaging workstation mostly using standard hardware components resulting in a universal handling system for different products. Ideally one setup for packaging a high variety of products and components can be implemented, which can be achieved by a teachable system architecture. This will open a new dimension of today’s way in how industrial robots are deployed, namely the collaboration of human workers together with robot co-workers. Only by driving the reliability and precision of today’s available technology to the limits and by additionally forcing the use of highly sophisticated software modules for worker detection and intention recognition, the cycle times can be reduced in order to justify the investment costs for additional complexity.

Keywords: human-robot collaboration,packaging,worker surveillance,human-machine interaction
Integrated Enabling Technologies for Efficient Electrical Personal Mobility (P-MOB)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Germany,Spain,Italy,Italy
Call:  (FP7-2010-ICT-GC, 2010)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 4351761.0
EU funding (EUR): 2788000.0
Participants: 8
Project status: CLOSED

The P-MOB project is aiming at breaking the link between the growth in transport capacity and increased fatalities, congestion and pollution. Transport is responsible for 73% of total oil consumption in EU, it is a major source of pollution and greenhouse gas emissions and the chief sector driving future growth in world oil demand. Most continents have an increasing dependence from primary energy. The demand on increased safety, reduced noxious and green house emissions has the following expectations: less than 30.000 fatalities in EU in the 2010, radical reduction of both CO2 and NOx aiming at zero local emissions. Transport will be faced to the followings: People and good will increase their need of mobility some 35% per decade for at least 3-4 decades - The number of megalopolis is increasing and most of the traffic will be urban - Urban centers are more and more congested and closed to traffic; 1% of our GDP is wasted in congestion - Mobility is related to invariants such as: people move 1 hour a day - The average speed, since it has measured the first time in 1923, is stable in the range 35-40km/h - people tend to relate mobility to a mental freedom and as many as 90% of km are run with a single occupant - In EU 1 more million cars are on the road every 50 days and globally the number of vehicles is projected to 2200 millions in the 2050. The emerging markets require at most low cost and environment compatible vehicles. P-MOB addresses the above challenges proposing: a novel concept of fully electrical personal mobility, reduction of system complexity concentrating on the essentials, advanced systems integration including solar cells, e-motor and magnetic torque control of the wheel, power-energy management, distributed pack of accumulators, technologies to sell-buy electricity by adaptable vehicle to grid connections. On an average day in South EU the propose vehicle is aiming at 20 km/day by using solar energy only.

Keywords: electrical vehicle,ultralight vehicle,pv integration,motor and magnetic gear integration,vehicle to grid
European stakeholders’ forum crossing value and innovation chains to explore needs, challenges and opportunities in further research and integration of ICT systems for Energy Efficiency in Buildings (ICT 4 E2B FORUM)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Coordination and support actions
Countries involved: Italy,Spain,Finland,Germany,Poland,Greece,Sweden
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-09-01
End date: 2012-12-31
Duration (months): 28.0
Total project cost (EUR): 1638829.0
EU funding (EUR): 995335.0
Participants: 7
Project status: CLOSED

ICT 4 E2B Forum is aimed at bringing together all relevant stakeholders involved in ICT systems and solutions for Energy Efficiency in Buildings, at identifying and reviewing the needs in terms of research and systems integration as well as at accelerating implementation and take-up. ICT 4 E2B Forum intends to promote, through community building activities, a better understanding, a closer dialogue and a more active cooperation between researchers, end-users/practitioners, building owners, technology-suppliers, and software developers as regards the use of ICT to support informed decision-making (both human and automated) in the current delivery and use of sustainable and energy-efficient buildings and districts. The ICT4E2B Forum project aims at the following objectives: - Bring together relevant stakeholders to identify and review the needs in terms of research and systems integration - Update the REEB research roadmap - Promote the use and further development of ICT for improved energy efficiency of buildings By accomplishing these objectives, ICT 4 E2B Forum will map the sector-specific priorities into a common view and vocabulary, thereby enabling communication and understanding between experts in different sectors that need to join forces in order that fundamental improvements in energy efficient buildings can be achieved. All this coordination work will support in defining future research directions as well as in channelling efforts, while favouring consensus buildings on the roadmap itself.

Keywords: energy efficiency,buildings
Efficient ENergy for EU Cultural Heritage (3ENCULT)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environmental technologies
Action type: Collaborative project
Countries involved: Italy,Denmark,Austria,United Kingdom,Germany,Spain,Germany,Netherlands,France,Belgium,Germany,Germany,Spain,Germany,Czechia,Netherlands
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-10-01
End date: 2014-03-31
Duration (months): 42.0
Total project cost (EUR): 6704955.74
EU funding (EUR): 4990475.0
Participants: 23
Project status: CLOSED

The project 3ENCULT bridges the gap between conservation of historic buildings and climate protection, which is not an antagonism at all: historic buildings will only survive if maintained as living space. Energy efficient retrofit is useful for structural protection as well as for comfort reasons - comfort for users and “comfort” for heritage collections. The joint task of conservation and energy efficient retrofit is highly interdisciplinary. The 3ENCULT consortium consists of scientists and stakeholders, especially on the level of SMEs, from the fields of diagnostics, conservation, building physics, sustainability, architecture and lighting up to cybernetics, thus guaranteeing both, the development of sustainable solutions and the impact on European economy. Eight case studies will demonstrate and verify solutions that are applicable to the majority of European built heritage in urban areas. Building owners and local historic preservation agencies are integrated in local case study teams. 3ENCULT will demonstrate the feasibility of “Factor 4” to “Factor 10” reduction in energy demand, depending on the case and the heritage value. The main objectives are the development of passive and active solutions for conservation and energy efficient retrofit including available products as well as new developments by involved SMEs, the definition of diagnosis and monitoring instruments, the long term monitoring (also for IEQ controlling) and the planning and evaluation tools and concepts supporting the implementation, the quality assurance and control of success of the energy retrofit measures. Guidelines will be disseminated to the scientific and public community. Finally, position papers will be issued suggesting possible integrations and/or implementations of the present regulation framework for improving energy efficiency of historic buildings in urban areas and in particular EPBD and Environmental Impact Assessment as well as Aalborg Commitments and Leipzig Charter.

Keywords: historic building,energy efficiency,urban development,factor 10,heating,cooling,res,lighting,led,active and passive sooling,integrated monitoring and control,ieq,simulation,epbd
Dissecting innate immunity to airborne opportunistic fungi through a genome-wide screen in Drosophila (FLY FUNGAL INTERPLAY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In recent years, airborne filamentous fungi have become major causes of life-threatening infections in an expanding population of severely immunocompromised individuals. Aspergillus remains the most common fungal pathogen in these patients, whereas Zygomycetes are emerging causes of fatal invasive fungal infections in many cancer institutions. Overall, the increasing frequency and spectrum of invasive fungal infections and the alarming rates of resistance to antifungal agents in fungi underscores the need to expand our knowledge on the immunopathogenesis of opportunistic fungal infections and develop novel therapeutic strategies. Importantly, the versatility of virulence mechanisms of fungi and the complexity of host defense mechanisms against fungi highlights the importance of understanding the molecular aspects of host-fungal interplay in robust experimental systems. Over the past decade, invertebrate mini-host models with well-characterized genetics and less complex immunity have been effectively used to explore several aspects of both fungal pathogenicity and antifungal host defense. These properties coupled with the robust genetics in Drosophila, make flies an ideal model to study the molecular aspects of host-fungal interaction. We have recently implemented Drosophila melanogaster as a model to study virulence mechanisms and the molecular aspects of host immune response to Zygomycetes. Surprisingly, we found that key aspects of the pathophysiology of zygomycosis in humans were appropriately modeled in fruit flies. In this proposal we expand on our previous work to: (a) Identify novel genes involved in Drosophila immunity against the most important airborne opportunistic fungi, Aspergillus and Zygomycetes, by performing a genome-wide screening strategy in Drosophila RNAi lines. (b) Confirm in humans the functional role of novel Drosophila host defense genes by silencing the relevant homologues in human phagocytic cells

Keywords: drosophila,immunity,fungi,aspergillus,zygomycetes
Programming effects of early life stress exposure to bereavement on future health: a perspective in 6.7 million subjects in 3 European countries (PROGEURO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Denmark
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2011-01-01
End date: 2016-06-30
Duration (months): 66.0
Total project cost (EUR): 1449950.0
EU funding (EUR): 1449950.0
Participants: 1
Project status: CLOSED

There have been significant challenges in the research areas of: 1. Foetal PROGramming. The widely use of growth variables as the indicators of foetal environment remains the major methodological limitation. And no research in humans has been able to examine the biomarkers at different programming stages from exposure itself to disease in one single study. 2. Stress. It remains difficult to assess stress and to obtain data on long-term health in a large study. The biological programming effects of prenatal stress need to be elucidated. 3. Bereavement. There is a significant knowledge gap in health of children bereaved by the death of a close relative. 4. Register-based research. To combine the multi-national data is necessary to understand the aetiology and the impact of rare disease and the effects of certain risk factors. But such a first attempt will face many obstacles. The novel approaches in this study are designed to meet all the above challenges. The study uses data from 21 national databases in Denmark, Sweden, and Finland. The first component is a population-based cohort of 6.7 million children. Its objective is to examine the programming effects of an early stress exposure, bereavement during prenatal or early years in life, on a wide range of health outcomes. The second biological component is a proof of concept for foetal programming, examining biomarkers along the pathway from prenatal stress to disease. The study is feasible only in EUROpean settings, which will strengthen the European leadership in epidemiology and public health. It may start a new era for joint European research in public health. The challenges may lead to difficulties and uncertainties for the study, which could also be the source of new scientific insights, hypotheses, and theories.

Keywords: foetal programming stress,bereavement,foetal origins of disease,programming,health service,health care