Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chirality-sensitive Nuclear Magnetoelectric Resonance (NMER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project lifts the blindness of nuclear magnetic resonance (NMR) spectroscopy to molecular chirality. First, we will observe chirality-sensitive magnetoelectric effects. Based on these effects, a new branch of molecular spectroscopy (abbreviated as NMER) is proposed, which will enable us to identify enantiomers directly without requiring chemical shift reagents or chiral solvents. Direct chiral NMR effects are very small and have not been previously detected, but this proposal will utilize several unique new strategies, such as hyperpolarization techniques and novel instrumentation, to dramatically enhance the chirality-sensitive NMR signals. This new approach is necessary to observe chirality-sensitive effects in solution at frequencies lower than 10 GHz. It permits 1) the direct discrimination of chiral molecules, 2) selective magnetic resonance imaging (MRI) of chiral molecules, and 3) determination of the absolute configuration of the molecule. In contrast to standard methods used in NMR, it does not require chemical modification of the sample. Consequently, it has many potential application fields ranging from analytical chemistry (determination of enantiopurity, resolution of complex mixtures of chiral substances), biochemistry (studies of interactions between chiral molecules), pharmaceutical science (diagnostic imaging, studies of the pharmaceutical mechanism of action). At the same time, the new methodology will dramatically increase the detection sensitivity, rendering it possible to 4) record NMR spectra from molecules in the gas phase under conditions of low partial pressure. This unique form of spectroscopy will be used as an analytical tool and will permit studies of chiral molecules interactions. In combination with state of the art quantum computations it will provide valuable data on NMR tensors and allow models of fundamental interactions involving chirality to be tested on the molecular scale.

Keywords: nuclear magnetic resonance
IMPROVING FLAVIVACCINE DEVELOPMENT BY IDENTIFYING ANTIGENS AND DESIGNING MRNA VACCINE CANDIDATES (FLAVIVACCINE HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 591721.25
EU funding (EUR): 591721.25
Participants: 2
Project status: CLOSED

Several mosquito-borne flaviviruses with pandemic potential lack effective vaccines, and where vaccines do exist, they often have limitations in terms of safety, efficacy, or accessibility. mRNA vaccines have the potential to address these issues by providing a safe, effective, flexible and rapidly deployable platform. The ambitious FLAVIVACCINE proposal aims at improving EU pandemic preparedness by developing an innovative broad-spectrum vaccine candidate against multiple mosquito-borne flaviviruses with epidemic potential. FLAVIVACCINE’s disruptive strategy is to target mosquito cell-derived extracellular vesicles (EVs) secreted into the mosquito saliva that increase the transmission of multiple mosquito-borne flaviviruses. FLAVIVACCINE proposal is solidly supported by the proof-of-concept that EV immunization protects against mosquito-borne flaviviral diseases and by an interdisciplinary consortium of 10 partners, including one vaccine developer. With the Hop-on facility call, the consortium wants to integrate i3S as a new member of excellence from the Widening countries to fulfil several scientific requirements for the success of the project: (i) the development of an mRNA vaccine platform ; (ii) a complementary approach to the identification of EV antigens ; and (iii) a world-level expertise in arthropod transmitted pathogens, in host/pathogen interactions in the skin, in EVs and in arthropod saliva-targeted immunization
Experimental and numerical studies for evaluation of surface integrity in post-processing of additively manufactured nickel-based alloy by machining process (AMacSurface)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

As a new technology, Additive Manufacturing (AM) provides an excellent opportunity to produce parts with complex geometry that would not be possible with traditional manufacturing methods. Against several advantages of AM technology, surface quality of an AM-built part might not be suitable for many applications. To solve this issue, one must use post-processing by machining process to obtain a suitable surface quality and dimensional accuracy of parts produced by AM. Regarding the machining processes, the desirable surface integrity of the machined components is one of the dominant requirements of the industries because it significantly affects the performance and service life of the final products. Inconel 718 alloy, as a difficult-to-cut material, has excellent properties. Not only few experimental studies are found in literature on machining of AM Inconel 718 alloy, but also, they have mostly limited to Conventional Machining (CM) processes. In addition, very few studies are found in literature on machining simulation of this new material due to absence of reliable material model for modeling the chip formation. To address this gap and aiming to push the fundamental science behind this problem, the main goal of the present project is to comprehensively evaluate the surface integrity condition after machining of AM Inconel 718. Firstly, the correlation between main AM parameters and machining characteristics are investigated. Then, a comparative experimental study will be conducted on CM, Cryogenic Cooling Machining (CCM) and Laser-Assisted Machining (LAM) to obtain desirable surface integrity after machining of AM Inconel 718 alloy. After that, fundamental advances for machining simulation of AM Inconel 718 will be presented. Based on this, identification of the new and reliable material model for machining simulation, innovative methods for predicting the surface integrity including microstructure changes and residual stress will be addressed at this project.

Keywords: machining processes,surface integrity,additive manufacturing,metallurgical alterations,simulation of cutting process,
Probing the impact of integrity and integration on societal trust in science (POIESIS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Research and Innovation actions
Countries involved: Denmark,Germany,Greece,Portugal,France,Spain,United Kingdom
Call: Societal trust in science, research and innovation (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1670875.0
EU funding (EUR): 1670875.0
Participants: 7
Project status: SIGNED

POIESIS examines research integrity and the integration of society in research as vehicles for responsible knowledge creation. It recognizes the intrinsic value of both research practices that align with ethical, legal, and professional standards, and the integration of relevant societal stakeholders in all phases of the research cycle. However, evidence of the impact of integrity and integration on societal (mis)trust in science, research, and innovation is lacking. POIESIS will carry out an extensive research programme to systematically examine the interrelatedness of integrity, integration, and trust, and the role of institutions in fostering a research climate that is conducive to societal trust in science. POIESIS will do this through (i) analysis of existing data streams on citizen trust, responsible and questionable research practices, and institutional policies to enhance responsible research; (ii) implementation of a portfolio of small scale studies, tailored to capture empirically the relatedness of integrity, integration, and trust, focusing on the chains of mediation that connect research practices with, ultimately, the interpretation and assessment of these practices by wider, non-academic publics; and (iii) conducting a set of participatory research actions in which stakeholders actively co-create knowledge, focusing on the role of institutions in nurturing responsible research cultures and practices that are conducive to trust in science. Through substantive engagement with stakeholders and an ambitious plan for dissemination and communication, POIESIS will create viable pathways to achieving its intended scientific, economic, and societal impacts. POIESIS will build a better knowledge base about the linkages of research practices and societal trust in science, providing targeted recommendations for designated user groups about tackling societal mistrust in science and strengthening the co-creation of research and innovation contents by society.

Keywords: research integrity open science practices societal integration citizen trust in science
Structural determination and dynamics of the mitochondrial import protein (MIM) by cryo-EM and magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) (MitoMemInsert)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

Mitochondria perform numerous key functions, from energy production to metabolic pathways, and are involved in ageing and cell death. All these functions rely on about 1000 different proteins, of which 99% are synthesized outside the organelle and have to be imported and inserted into the right compartment. These import and insertion are particularly demanding for the membrane proteins as they are inherently aggregation-prone. How α-helical membrane proteins (MPs) are inserted into the mitochondrial outer membrane (MOM) is currently poorly understood. In particular, the structure of the insertase responsible for inserting tens of these α-helical MPs into this membrane, called mitochondrial import protein (MIM) in yeast, is unknown. My MitoMemInsert project addresses this important knowledge gap, by determining the atomic-resolution structure of MIM, by using cryo-EM combined with magic-angle-spinning nuclear magnetic resonance spectroscopy to resolve MIM’s structure in a lipid-bilayer environment. This will open avenues to see how the MIM complex engages with polypeptides that shall be inserted into the membrane by MIM (so-called precursor proteins or ‘preproteins’). Such a “static” structure determination would already be a big leap for the field: it will be the first structure of a MOM insertase of α-helical MPs. As it is thought to have a novel architecture, this structure will provide new insights into MP insertion machinery in general. In addition, I will use NMR to study the dynamics of this machinery, which I believe, will add important mechanistic knowledge of how the MIM complex engages with MPs that are being inserted in the MOM. Overall, making use of my previous technical expertise, and adding new competences to my skill set, a combination of biophysical and structural approaches will allow me to resolve this important, and hitherto poorly addressed question in mitochondrial biogenesis and, more generally, biophysics.

Keywords: mitochondrial import protein mim cryo em ssnmr dynamics cell free translation system
A natural breast for cancer survivors: resorbable implant supporting tissue regeneration (regenera)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 3569441.25
EU funding (EUR): 2498600.0
Participants: 1
Project status: CLOSED

Of the 3 million women undergoing breast cancer resection every year, only a few opt for breast reconstruction due to pain, concerns about follow-up procedures and the lack of options. For lumpectomy patients traditional implants cannot be used, with only ~20-30% of lumpectomies being reconstructed. Autologous tissue transfer requires multiple painful interventions to reconstruct large volumes and obtain satisfactory results. Furthermore, both implants and autologous solutions require multiple follow-up surgeries, increasing costs and pain for the patients. REGENERA will be a unique solution for lumpectomy patients: a resorbable implant designed to restore a natural breast through tissue self-regeneration. It is a cell-free porous scaffold made of resorbable biocompatible poly(urethane-ester-ether) with a biomimetic architecture. It is designed to avoid follow-up surgeries and eliminate the risks associated with silicone and saline implants (rupture, leakage, ALCL) and fat grafting.

Keywords: regenerative medicine,breast cancer,breast surgery,biocompatible scaffold,resorbable implant,tissue regeneration,breast reconstruction,lumpectomy
Quantitative Rectifiability: from Vitushkin's conjecture to Manifold Learning (QuRe-ViMaL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

For compact planar sets, an analogue to the classic travelling salesman problem is: when can all points in a compact set E be traversed by a rectifiable curve? and how long should such a curve be? P. Jones came up with an answer in his influential Analyst's Travelling Salesman Theorem (ATST). Recent work by the PI and collaborators suggest that fundamental questions at the interface between Geometric Measure Theory (GMT), Harmonic Analysis (HA), PDEs and Machine Learning (ML) have at their core establishing higher dimensional analogues of Jones' ATST. This proposal takes up this challenge by focussing onto three concrete investigations: 1) We aim at solving a long-standing and notoriously difficult conjecture of Vitushkin on the connection between analytic capacity and Favard length. As a result of our strategy, we will prove a quantification of the classical Besicovitch-Federer projections theorem. 2) We study the interplay between the geometry and the differentiability structure a set can support, resulting in a) a geometric characterisation of domains admitting a Sobolev trace theorem, and b) a geometric converse of Rademacher's theorem, which answers a notable open question in the David-Semmes theory of uniform rectifiability. 3) We study the geometry of point clouds by developing a corona-type construction which tests whether the data points lie near a parametrisable surface; this is a way of testing the manifold hypothesis, relied upon by most nonlinear dimensionality reduction algortihms in data analysis. Our framework provide a common language within which we tackle these diverse issues. Hence, achieving our objectives will not only result in major subject-specific breakthroughs, but, just as importantly, will develop and expand this `language', thus providing fertile ground for multidisciplinary interactions to take place.

Keywords: geometric measure theory,harmonic analysis,rectifiability,manifold learning
Bankable by Design, Continuous, and Predictive Climate Adaptation Investments with Co-Benefits (CLIMINVEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Italy,Spain,Cyprus,Greece,Belgium,United Kingdom,Portugal,Bulgaria,Germany,Slovakia,France
Call: Demonstration of approaches to improve bankability of solutions by design, addressing the co-benefits (mitigation and adaptation) to improve revenues streams (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 11810143.25
EU funding (EUR): 8999807.76
Participants: 23
Project status: SIGNED

CLIMINVEST is joint effort of sustainability experts and finance/investing experts to improve the bankability of climate adaptation solutions. In this direction, the project will develop, integrate and validate tools and techniques that will empower climate adaptation stakeholders to develop “bankable-by-design” (BbD) projects with a positive ROI, including projects that are continually assessed in order to proactively identify and remedy issues that can affect their bankability. Moreover, CLIMINVEST will facilitate private investors to assess them, and to include them in their portfolios and ESG strategies. Based on the project’s BbD framework, local/regional governments and operators of climate-adaptation solutions will greatly benefit from CLIMINVEST techniques and blueprints for developing and deploying bankable solutions that can be integrated with broader projects and deliver co-benefits in conjunction with other climate mitigation efforts. Furthermore, CLIMINVEST will provide investors with risk assessment and ESG reporting tools for projects with climate adaptation elements towards lowering the barriers that hinder their engagement in climatic adaptation projects. CLIMINVEST will develop and offer a marketplace of bankable climate adaptation projects and solutions, which will boost the discoverability of “best practice” solutions, while also facilitating their replication, repurposing and wider use. The project will build a vibrant ecosystem of interested stakeholders around this marketplace, including local/regional governments, sustainability experts, private investors, and policy makers. The project’s platform and associated ecosystem will serve as a basis for the exploitation, sustainability and wider use of the project’s results. In this direction, the project will devise and validate models for the monetization of services of the project’s marketplace.

Keywords: bankability by design,esg,predictive bankability,analytics,co benefits,public private partnership,co benefits,marketplace
ESTimation of the prehistoric population of Eurasia based on a large number of Records (ESTER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1981430.0
EU funding (EUR): 1981430.0
Participants: 1
Project status: SIGNED

Understanding population trends over the past 12,000 years is crucial for unraveling the complexities of social development. Population size influences social structures, exchange systems, environmental interactions, cultural transmission, and societal resilience. Current global population figures, derived since the 1970s, are educated guesses based on limited data and deductive methods, hindering accurate prehistoric assessments. Regional studies, emerging data sources, and innovative methods offer new possibilities, exemplified by the XRONOS database, a significant contribution from our research group. The ESTER project proposes a groundbreaking approach, employing hierarchical Bayesian modeling and data assimilation techniques to integrate heterogeneous big data into population development models. This method evaluates data reliability, compensates for missing information, and facilitates regionalized estimates balancing varying data availability. Focused on Europe and Western Asia from 12,000 to 2,000 BP, the project aims to provide the first big-data-based regionalized population estimate. Sub-projects investigate climatic shifts, societal collapses, and the impact of innovations like agriculture on population dynamics. The project aligns with Ester Boserup's theories, reflecting her positive vision of humanity capable of change. The ESTER project introduces a novel methodology, offering valid bases for investigating cultural and social configurations dependent on population numbers. It provides confidence intervals, 50-year temporal resolution, and absolute population numbers. These results can test causal relationships with climatic changes and volcanic eruptions. Beyond archaeology, they offer indicators for human impact and land use, aiding various palaeosciences in investigating human-environment relationships with unprecedented quality and reliability, fostering awareness of our past and its connection to ongoing global change.

Keywords: computational archaeology,population estimates,prehistoric archaeology,human impact,bayesian hierarchical modeling