Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-test2, wine analysis kit for Brettanomyces yeast identification (Self-Brett 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Italian wine market is a cornerstone of the national agri-food sector and is characterized by increasing high-quality wine demand from consumers. Therefore, issues hindering the achievement of wines able to satisfy all market requirements still occur. Brettanomyces spoilage is one of these and it leads to off-flavours and odor formation that highly affect wine quality, causing serious economic losses. The present innovation concerns the setup of a revolutionary device for Brettanomyces self-detection, hereafter referred to as Self-brett®: an easy to use, quick, reliable and cheap new product. Self-brett® enables anyone to carry out self-analysis on Brettanomyces spoilage at any moment of the wine making process, without requiring the involvement of specialized staff, equipments or LAB facilities. Wine-makers, oenologists, oenological product retailers and producers as well as analytical laboratories will embrace Self-brett® because it represents exactly what the wine market is missing now. GRAPE mission is addressed to translate in market services the technical-scientific knowledge acquired by the founders during their academic carriers. Through the development of Self-brett®, already patented, once again GRAPE shows to be innovative and prompt to fulfill customers’ needs, thus offering the first device for wine self-analysis, available at low price, with the potential to reach the entire wine market. Based on an initial investment of 783.180€ (1st and 2nd yr), GRAPE estimates to sell 420K devices by the end of the second year of commercialization (4th yr) and to reach € 4.235.000 of revenues, corresponding at € 1.130.000 net profits and 29,1% ROI, together with a job growth higher than 180%. GRAPE needs to enter the SME Instrument phase 1 to finalize the Self-brett® development and prepare it for the undoubtedly successful launch on the market: Self-brett® is what all wineries need.

Keywords: wine,wine spoilage,self test wine analysis kit,brettanomyces bruxellensis,rapid detection,ready to use device,cheap analysis,on site analysis
Waste heat recovery for industrial heat intensive processes (Hot chips)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Norway
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 3944847.5
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

The proposal addresses the initial exploitation of a vast business opportunity for waste heat recovery (WHR) in industrial processes worldwide. 12-25% of national energy consumption in industrial countries is used for drying, one of many processes suitable for WHR. The industries paper, petrochemical, food, wood and plastic have a moderate calculated potential need of 4400 high temperature heat pumps (HTHP) delivering heat between 100 and 150 oC in Europe alone. There is a technology gap in the market for heat pumps delivering temperatures between 100 and 200 oC according to a comprehensive report from IERE (Stuttgart University), a necessity to fully exploit the vast potential in industrial processes. Tocircle is maturing its compressor and integrating it in a High Temperature Heat pump (HTHP) to fill this gap. The first process to address is the European potato frying industry consisting of 250 known frying lines. Their energy (gas) consumption totals 8 TWh a year at a value of 210 M€. The corresponding emission is 1.5 Mt CO2. A reduction in fossil consumption by 70% can be achieved by integrating a HTHP in the deep-frying process. The global market value of frozen French Fries is about 19 billion $ with Europe as the largest market, then North-America and Asia-Pacific. They represent the growth path for our potato frying solution. Commercial objectives: Tocircle will reach annual HTHP sales of 63 M€ in Y3 after project completion, a profit of 16 M€ and creating 100+ new jobs in Europe from the European potato frying segment alone. Technical objectives: to mature Tocircle’s patented rotary vane compressor using Evaporative Compression Technology (ECT), to integrate an ECT compressor package into a full-scale pilot HTHP system and to demonstrate the solution at one of 11 frying lines of company Aviko, a major international French fries producer. ECT is a disruptive technology allowing the HPHT to deliver temperatures up to 200 oC

Keywords: waste heat recovery,heat intensive,high temperature heat pump,multiphase compression,deep frying,ammonia,potato chips,french fries,tocircle,fandb,evaporative compression technology
REVOLUTIONISING THE PRODUCTION AND PACKAGING OF CABLES (ZERO260)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Windak is a world leading specialist in cable packaging machinery originating in Sweden 1994. Our first client was Volvo for a complete pallet handling packaging system. Since our inception to the present day our innovative technologies include high speed rewind lines for fiber optic cable, fully automatic spooling lines, versatile coiling lines, a multitude of palletizers and breakthrough coiling solutions for packaging cable products into boxes or bags. We have delivered our products to 30 countries worldwide and our customers are amongst the leaders of industry. We are proud to announce that we have a 60% market share in the North American market. We strive for innovative products and we have the next generation product, the ZERO260. Operationally it outperforms everything else on the market in several key areas. We have managed to double operational capacity, reduce the machinery footprint to one-third and allow for continuous, uninterrupted production as our machine does not need to be switched off during cable changeovers. The technical competencies are described in greater detail in the main proposal and we feel this will enable us to stay ahead of the competition. More importantly, this allows Europe to maintain its market dominance in the sector and mitigate the threat from Taiwan, China and India.

Keywords: innovation,unique product,redefining excellence,enhanced productivity
FIRE-IN - Fire and Rescue Innovation Network (FIRE-IN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Poland,Sweden,Sweden,Poland,Greece,France,France,France,France,Czechia
Call: Pan European Networks of practitioners and other actors in the field of security (H2020-SEC-2016-2017-1, 2016)
Start date: 2017-05-01
End date: 2022-10-31
Duration (months): 66.0
Total project cost (EUR): 3496241.25
EU funding (EUR): 3496241.25
Participants: 19
Project status: CLOSED

FIRE-IN has been designed to raise the security level of EU citizens by improving the national and European Fire & Rescue (F&R) capability development process. FIRE-IN addresses the concern that capability-driven research and innovation in this area needs much stronger guidance from practitioners and better exploitation of the technology potentially available for the discipline. We argue that this is to be achieved by practitioners more effectively coordinating on operational needs, on available research and innovation, on standardisation, and on test & demonstration and training. Further, we claim the need for the development of a common research culture that is to be achieved by better cooperation between practitioner and research/industry organisations. FIRE-IN addresses these objectives through four main areas of activity: (i) the identification and harmonisation of operational capability gaps based on the contribution provided by a significant and heterogeneous practitioner network, (ii) the identification of promising solutions to address those gaps through monitoring and screening of research outcomes and the continuous involvement of research and industry representatives, (iii) the definition of a F&R Strategic Research and Standardisation Agenda (SRSA) based on the previous elements as well as (iv) the development of a concept for more efficient use of test & demonstration and training facilities to support innovation and joint skill development. The overarching result of the project will be a proven process for organising F&R capability-driven research based on a wide practitioner and research and innovation network. The network will be linked at cross-domain and cross-border level and will feed harmonised operational requirements (or challenges) into national and EU capability development, i.e. research, innovation, procurement and standardisation programmes.

Keywords: fire and rescue,civil protection,first responders,capability development,practitioners,innovation,research,test and demonstration,training
Pervasive Upstream Non-Coding Transcription Underpinning Adaptation (PUNCTUATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1499952.0
EU funding (EUR): 1499952.0
Participants: 1
Project status: SIGNED

Genomic DNA represents the blueprint of life: it instructs solutions to challenges during life cycles of organisms. Curiously DNA in higher organisms is mostly non-protein coding (e.g. 97% in human). The popular “junk-DNA” hypothesis postulates that this non-coding DNA is non-functional. However, high-throughput transcriptomics indicates that this may be an over-simplification as most non-coding DNA is transcribed. This pervasive transcription yields two molecular events that may be functional: 1.) resulting long non-coding RNA (lncRNA) molecules, and 2.) the act of pervasive transcription itself. Whereas lncRNA sequences and functions differ on a case-by-case basis, RNA polymerase II (Pol II) transcribes most lncRNA. Pol II activity leaves molecular marks that specify transcription stages. The profiles of stage-specific activities instruct separation and fidelity of transcription units (genomic punctuation). Pervasive transcription affects genomic punctuation: upstream lncRNA transcription over gene promoters can repress downstream gene expression, also referred to as tandem Transcriptional Interference (tTI). Even though tTI was first reported decades ago a systematic characterization of tTI is lacking. Guided by my expertise in lncRNA transcription I recently identified the genetic material to dissect tTI in plants as an independent group leader. My planned research promises to reveal the genetic architecture and the molecular hallmarks defining tTI in higher organisms. Environmental lncRNA transcription variability may trigger tTI to promote organismal responses to changing conditions. We will address the roles of tTI in plant cold response to test this hypothesis. I anticipate our findings to inform on the fraction of pervasive transcription engaging in tTI. My proposal promises to advance our understanding of genomes by reconciling how the transcription of variable non-coding DNA sequences can elicit equivalent functions.

Keywords: long non coding rna,lncrna,rna polymerase ii,transcriptional interference,co transcriptional control,the non coding genome,pant biology
Nanoparticles with switchable shells for virus sensing and inhibition (rSAMs-NANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, this relies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are: 1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess such systems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection. Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particles Under 2) we will develop influenza virus sensors with subtyping capability within human and animal virus strains. The sensors will be validated with respect to benchmark assays.

Keywords: virus sensor,influenza,ebola,self assembled monolayer,switchable,multivalent interactions,self,assembly,antiviral drug,nanomaterials,amidine,glycan,lectin,sialic acid
Contemporary Bioethics and the History of the Unborn in Islam (COBHUNI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1956338.0
EU funding (EUR): 1956338.0
Participants: 1
Project status: CLOSED

COBHUNI will for the first time provide a comprehensive investigation of the History of the Unborn in Islam until today. This aims at diversifying our understanding of how pre-natal life is conceptualized in texts of Islamic normativity. At the center will be the analysis of statements in the Qur’an and the prophetic sayings (Hadith) relating to the unborn and the commentary tradition which evolved around them over ca. the last millennium. The objectives of COBHUNI: 1. Thematically: Showing how processes of communication a) between religious communities, b) different regions within the Muslim community, and c) the emergence of modern medicine impacted on the imagination of the unborn. 2. Conceptually: Drawing on three new approaches in the study of Islam: a) emergence of Islam within the context of late antiquity, b) canonization studies, and c) study of exegetical literature. 3. Methodologically: Developing and applying computerlinguistic approaches to Arabic text material and thus improving significantly on the state of the art of Arabic Digital Humanities. The realization will encompass the analysis of the text material along two axes. Vertical axis: citations and cross-referencing within the exegetical tradition; Horizontal axis: contextualizing the exegesis and scrutinizing links to other genres. I have been working on contemporary Islamic Bioethics since 2003 and since 2008 I have broadened my research to the historical scope of the topic. With my comprehensive experience in the study of Contemporary Islamic Bioethics and historical texts from Islamic Normativity and my knowledge in the study of Arabic Qur’an and Hadith exegesis I will be able to successfully lead this cutting-edge project. My team will generate additional data and enhance the IT applications necessary for its analysis. My project will offer powerful approaches to show the complex web of influences impacting on the imaginations of the unborn in Islam.

Keywords: islam,bioethics,pre natal life,computational linguistic applications
Plant movements and mechano-perception: from biophysics to biomimetics (PLANTMOVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 1933996.0
EU funding (EUR): 1933996.0
Participants: 1
Project status: CLOSED

How to transport fluids, move solids or perceive mechanical signals without the equivalent of pumps, muscles or nerves? This ongoing challenge, which is relevant from microfluidics to robotics, has long been solved by plants. In this project, I wish to gather my cross-disciplinary background in plant mechanics, soft matter physics and granular materials to address some of the fundamental mechanisms used by plants to perceive mechanical stimuli and generate motion. The project focuses on three major issues in plant biophysics, which all involve the coupling between a fluid (water in the vascular network or in the plant cell, cellular cytoplasm) and a solid (plant cell wall, starch grains in gravity-sensing cells): (i) How mechanical signals are perceived and transported within the plant and what is the role of the water pressure in this long-distance signalling. (ii) How plants sense and respond to gravity and how this response is related to the granular nature of the sensor at the cellular level. (iii) How plants perform rapid motion and what is the role of osmotic motors and cell wall actuation in this process, using the carnivorous plant Venus flytrap as a paradigm for study. The global approach will combine experiments on physical systems mimicking the key features of plant tissue and in situ experiments on plants, in strong collaboration with plant physiologists and agronomists. Experiments will be performed both at the organ level (growth kinematics, response to strain and force stimuli) and at the tissue and cellular level (cell imaging, micro-indentation, cell pressure probe). This multi-disciplinary and multi-scale approach should help to fill the gap in our understanding of basic plant functions and offers new strategies to design smart soft materials and fluids inspired by plant sensors and motility mechanism.

Keywords: plant biomechanics,plant movements,poroelasticity,osmotic pressure,granular materials,non brownian suspensions,cellular materials,microfluidic
Mechanisms of Auxin-dependent Signaling in the Endoplasmic Reticulum (AuxinER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 1441125.0
EU funding (EUR): 1441125.0
Participants: 1
Project status: CLOSED

The phytohormone auxin has profound importance for plant development. The extracellular AUXIN BINDING PROTEIN1 (ABP1) and the nuclear AUXIN F-BOX PROTEINs (TIR1/AFBs) auxin receptors perceive fast, non-genomic and slow, genomic auxin responses, respectively. Despite the fact that ABP1 mainly localizes to the endoplasmic reticulum (ER), until now it has been proposed to be active only in the extracellular matrix (reviewed in Sauer and Kleine-Vehn, 2011). Just recently, ABP1 function was also linked to genomic responses, modulating TIR1/AFB-dependent processes (Tromas et al., 2013). Intriguingly, the genomic effect of ABP1 appears to be at least partially independent of the endogenous auxin indole 3-acetic acid (IAA) (Paque et al., 2014). In this proposal my main research objective is to unravel the importance of the ER for genomic auxin responses. The PIN-LIKES (PILS) putative carriers for auxinic compounds also localize to the ER and determine the cellular sensitivity to auxin. PILS5 gain-of-function reduces canonical auxin signaling (Barbez et al., 2012) and phenocopies abp1 knock down lines (Barbez et al., 2012, Paque et al., 2014). Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER. Based on our unpublished data, an IAA metabolite could play a role in ABP1-dependent processes in the ER, possibly providing feedback on the canonical nuclear IAA-signaling. I hypothesize that the genomic auxin response may be an integration of auxin- and auxin-metabolite-dependent nuclear and ER localized signaling, respectively. This proposed project aims to characterize a novel auxin-signaling paradigm in plants. We will employ state of the art interdisciplinary (biochemical, biophysical, computational modeling, molecular, and genetic) methods to assess the projected research. The identification of the proposed auxin conjugate-dependent signal could have far reaching plant developmental and biotechnological importance.