Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A diagnostic test for cochlear synaptopathy in humans (CochSyn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The CochSyn-test aims to diagnose the first signs of permanent hearing damage with a 10-15 min clinical hearing- screening test. The test quantifies cochlear synaptopathy, i.e. damage to the cochlear auditory-nerve fiber synapses due to ageing, noise-exposure or ototoxicity, with a non-invasive auditory test. Because synaptopathy is associated with reduced speech intelligibility and occurs before the audiogram shows signs of hearing damage, our test is more sensitive than the audiogram (present clinical standard) and can quantify a widespread form of sensorineural hearing loss. The CochSyn test makes early-diagnosis and early-intervention possible, which the WHO determined as cost- effective in reducing the financial burden associated with untreated hearing loss. In this PoC project, we plan to fine-tune the CochSyn-test and build a normative dataset of test outcomes for a diverse population of people at risk for synaptopathy. This dataset is necessary to (i) determine the application area of the test and enable a precise diagnostic interpretation, (ii) convince ENT doctors about adopting the test and companies to invest in it, and (iii), convince health agencies and policy makers that synaptopathy is an important health risk, given its impact on degrading speech intelligibility in noisy listening environments.

Keywords: auditory brainstem responses,auditory eeg,sensorineural hearing loss,hearing diagnostics,hearing loss
Tracking discoursal shift in news media representation of economic inequality: developing and applying corpus linguistic and critical discourse analysis methods (DINEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

DINEQ explores changes in the discoursal representation of degrees of economic inequality in selected British newspapers in 1971 and 2011. It is the first applied diachronic linguistic study to combine a consideration of the socio-political history in Britain in those forty years, a comparative analysis of selected public discourses in those two years, and a semantic, grammatical and lexical study of media representations of wealth inequality. The methodological approach used for this project is primarily Corpus Linguistic, but draws also on Systemic-Functional Grammar, and adopts a broadly Critical Discourse Analytic theory of discourse. The interdisciplinary nature of this project is complemented with the expertise of the Supervisor, Prof. Michael Toolan, and the Fellow, Dr. Eva Gomez, both experts in Stylistics and Discourse Analysis. The quality of the proposed project is ensured by the commitment of the members involved and the support committed by the University of Birmingham, one of the leading universities in Europe. This innovative study aims to demonstrate that rigorous and systematic corpus-based discourse analysis can establish discursive change over time, of a kind that is so dispersed and gradual that it is imperceptible in the day-to-day newspaper-reading of the ordinary reader.

Keywords: discourse,economic inequality,british press,corpus linguistics,critical discourse analysis
Delivering BEACON Caresystem – a ground-breaking ICT-enabled ICU bed-side assistant providing recommenda-tions for critical mechanical ventilation support for better care and reduced costs. (ICU-CARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 3298290.0
EU funding (EUR): 2308803.0
Participants: 1
Project status: CLOSED

We are Mermaid Care - provider of leading ICT-based care systems for optimizing Ventilation Management within the Intensive Care Units (ICU) and anesthesia segment. ICUs are some of the most resource-demanding hospital units consuming 20% of all hospital costs. A major contributor is the Length of Stay (LOS) of ventilated patients. Key to reducing costs is to reduce LOS. The process is difficult, as doctors have to decide on the proper ventilation strategy in a matter of minutes during his/her few daily rounds. Studies show that LOS can be drastically reduced if experts oversee the ventilation management 24/7 – clearly not a sustainable solution, we see a clear need for an ICT-based advisory system to aid 24/7 management. We will deliver BEACON Caresystem – a breakthrough ventilation assistant. BEACON will potentially reduce LOS with 15-25% – additionally cutting ICU costs with the proportional amount. As an add-on to existing ventilation systems, it provides optimal ventilation recommendations based on non-stop, personalised monitoring. Basically a bed-site specialist. Based on unique diagnostics algorithms and physiological models, it recommends weaning off scenarios, supporting the critical decision-making processes. No one else offers this diagnostic and physiology-based approach (individualised care). The ICT-approach means BEACON changes workflow and empowers ICU nurses to take over a vast part of the management. In the proposed project, BEACON value proposition (LOS reduction) will be clinically documented. Following the project, BEACON is launched on the EU market, allowing European hospitals to cut ICU costs and improve healthcare procedures. This project will allow us to accelerate sales volume from €0.8M in Y1 to €43M in Y5 and create 30 new European work places. Our innovation is based on +15 years of research and 10 patents. In Q6-2017 we submitted a very similar proposal receiving a Seal of Excellence with a score of 13.71.

Keywords: ventilation management,emergency care,acute care
Elucidating polarity pathways in the fly and murine intestinal epithelium (INTEPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-05
End date: 2020-04-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cell polarity is essential for normal cell function and for various developmental processes, such as axis determination, asymmetric stem cell divisions, and cell migration. Polarity is integral for tissue organization and failure in this process is a hallmark of human malignancies. Extensive studies in diverse model systems have helped to establish recurring mechanisms that drive polarity in various cell types. Yet, these conserved polarity regulators are not universally required and it emerges that some cells use distinct polarity mechanisms in a context dependent manner. For example, the polarization of the Drosophila intestinal epithelium does not require any of the canonical polarity regulators, unlike all other well-characterized Drosophila epithelia. However, little is known about how this unconventional polarity is established. This proposal aims to elucidate novel alternative polarity pathways in the intestinal epithelium of Drosophila. I will conduct a large--scale forward genetic screen to identify novel polarity regulators in the fly gut epithelium. Furthermore, I will examine the functional conservation of the newly identified polarity regulators in the murine intestinal stem cell organoids. Overall, this proposal will shed novel insights into the epithelial biology of the intestinal system.

Keywords: cell polarity,epithelial biology,in vivo imaging,drosophila,3d culture,organoids,adult intestine
k-space Neural computation with magnEtic exciTations (k-NET)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Hungary,France,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 3036001.25
EU funding (EUR): 3036001.25
Participants: 8
Project status: SIGNED

Artificial neural networks represent a key component of neuro-inspired computing for non-Boolean computational tasks. They emulate the brain by using nonlinear elements acting as neurons that are interconnected through artificial synapses. However, such physical implementations face two major challenges. First, interconnectivity is often constrained because of limits in lithography techniques and circuit architecture design; connections are limited to 100s, compared with 10000s in the human brain. Second, changing the weight of these individual interconnects dynamically requires additional memory elements attached to these links. Here, we propose an innovative architecture to circumvent these issues. It is based on the idea that dynamical hyperconnectivity can be implemented not in real space but in reciprocal or k-space. To demonstrate this novel approach we have selected ferromagnetic nanostructures in which populations of spin waves – the elementary excitations – play the role of neurons. The key feature of magnetization dynamics is its strong nonlinearity, which, when coupled with external stimuli like applied fields and currents, translates into two useful features: (i) nonlinear interactions through exchange and dipole-dipole interactions couple potentially all spin wave modes together, thereby creating high connectivity; (ii) the strength of the coupling depends on the population of each k mode, thereby allowing for synaptic weights to be modified dynamically. The breakthrough concept here is that real-space interconnections are not necessary to achieve hyper-connectivity or reconfigurable synaptic weights. The final goal is to provide a proof-of-concept of a k-space neural network based on interacting spin waves in low-loss materials such as yttrium iron garnet (YIG). The relevant spin wave eigenmodes are in the GHz range and can be accessed by microwave fields and spin-orbit torques to achieve k-space Neural computation with magnEtic exciTations.

Keywords: magnonics,spin waves,spin orbit torques,low loss magnetic materials,neuromorphic computing,neural network,nonlinear dynamical systems,learning algorithms
QUSTEC: international, interdisciplinary and intersectoral doctoral programme in Quantum Science and Technologies (QUSTEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-05-15
End date: 2025-07-14
Duration (months): 74.0
Total project cost (EUR): 8461440.0
EU funding (EUR): 4230720.0
Participants: 1
Project status: SIGNED

QUSTEC offers interdisciplinary, intersectoral and international doctoral training in the field of quantum science and technologies (QST) to 39 early-stage researchers. The coordinator is the European Grouping of Territorial Cooperation (EGTC) Eucor – The European Campus that consists of five universities that are located in the Upper Rhine research area, at the border between France, Germany and Switzerland. Within QUSTEC programme, the Eucor Members, University of Basel, University of Freiburg, University of Strasbourg and the Karlsruhe Institute of Technology are joined by IBM-Research in Zurich and Walther-Meissner-Institute in Munich. The QUSTEC training programme is in line with the European Charter for Researchers, the Code of Conduct for the Recruitment of Researchers and the EU Principles for Innovative Doctoral Training. Fellows can choose their research projects among the offer of the partner organisations and will be enrolled in a doctoral programme of one of the partaking universities. They are selected in an open, transparent, merit-based procedure based on international peer review. All early-stage researchers are offered a generous 4-year employment contract with the corresponding social security provisions. An individual training panel in a three-tier training programme will supervise them. With a budget of 9 139 308,48 Euro and an overall duration of 6 years, the QUSTEC programme offers one call and one reserve call for candidates from the science, technology, engineering and mathematics (STEM) field. The scientific focus lies on the six areas of quantum electronics, artificial quantum systems, quantum nanodevices, non-equilibrium quantum systems, quantum resources, and quantum simulation. The MSCA COFUND support serves as a nucleus for early-stage research career training, creates synergies among the partner institutions and contributes to Europe’s leadership role in the emerging field of QST.

Keywords: international,interdisciplinary,intersectoral doctoral training,quantum science and technologies,mobility,quantum simulations and computing,quantum nano devices,quantum electronics
Chronotype, health and family: The role of biology, socio- and natural environment and their interaction (CHRONO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 2499811.0
EU funding (EUR): 2499811.0
Participants: 1
Project status: SIGNED

The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g., light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g., working regulations) and psychological and familial consequences of nonstandard work schedules. For the first time CHRONO bridges these disparate disciplines to ask: What is the role of biology, the natural and socio-environment and their interaction on predicting and understanding resilience to chronotype disruption and how does this in turn impact an individual’s health (sleep, cancer, obesity, digestive problems) and family (partnership, children) outcomes? I propose to: (1) develop a multifactor interdisciplinary theoretical model; (2) disrupt data collection by crowdsourcing a sociogenomic dataset with novel measures; (3) discover and validate with informed machine learning innovative measures of chronotype (molecular genetic, accelerometer, microbiome, patient-record, self-reported) and the natural and socio-environment; (4) ask fundamentally new substantive questions to determine how chronotype disruption influences health and family outcomes and, via Biology x Environment interaction (BxE), whether this is moderated by the natural or socio-environment; and, (5) develop new statistical models and methods to cope with contentious issues, answer longitudinal questions and engage in novel quasi-experiments (e.g., policy and life course changes) to transcend description to identify endogenous factors and causal mechanisms. Interdisciplinary in the truest sense, CHRONO will overturn long-held substantive findings of the causes and consequences of chronotype disruption.

Keywords: circadian rhythms,chronotype,family,health,genetics,microbiome
Technological Cultures in Capuchin Monkeys: an Archeological and Behavioural exploration (TechnoC-Cap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-12-10
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Animal cultures represent an often neglected layer of biological diversity and a powerful model for the study of human evolution. Robust capuchin monkeys (Sapajus spp.) are emerging as a new model for cultural and technological evolution in humans, phylogenetically independent from the established chimpanzee model. Available data suggest a great potential for cultural diversity across the robust capuchins range, especially within the tool use domain. However, capuchins’ behavioural diversity remains so far mostly unknown. This fellowship will establish an innovative, multidisciplinary protocol to map tool use traditions across space and time in wild capuchins not habituated to human presence. The training through research activity will allow me, a field primatologist, to acquire essential skills to describe animal tool use from an archeological perspective and strengthen my ability to conceive, design and apply behavioral experiments. Specifically, I propose to: - use environmental surveys and camera trap monitoring to describe tool use behaviour at a new site in terms of behavioural repertoire, tool selection and tool transport; - test and apply a new approach, based on field experiments, to detect tool use behaviours in primate populations not habituated to human presence; - excavate tool use sites to trace the temporal development of technological traditions at a previously unstudied geographical location with unhabituated capuchins. This research will i) extend, for the first time, the field of primate archeology to unhabituated populations of non-human tool-using primates and ii) serve as a platform to launch a large-scale, multidisciplinary exploration of technological and cultural diversity in robust capuchins. This will ultimately allow to tackle the ecological and cultural drivers of behavioural diversity in capuchins and to shed light into evolutionary scenarios about human cultural evolution and the emergence of tool use.

Keywords: capuchin monkeys,animal tool use,primate cultures,lithic technology,archeological method,field experiments,camera traps,unhabituated populations,cultural evolution,cognitive skills
Investigating the Ecology, Composition and Exploitability of Wild Cereal Habitats in Relation to Agricultural Origins in the Near East (NICHE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The project combines analyses on the taxonomic composition, isotopic signature, economic exploitability and functional ecology of wild cereal habitats in the Near East, which will create a data basis that allows to more reliably trace the origins of arable weeds and the development of subsistence strategies at the dawn of agricultural societies. During the past decades, archaeobotanical research on early cultivation has strongly focused on the wild cereals, their experimental cultivation, and on identifying arable weeds in archaeobotanical assemblages for tracing the first cultivation activities. However, little is known about the origins of arable weeds and their association with unmanaged wild cereal habitats, putting doubt on their reliability to indicate the beginnings of cultivation. In addition, medium- and large-seeded wild grasses that grow together with wild cereals in modern stands occur abundantly at Early Neolithic sites. Reconstructing subsistence developments during the Neolithic transition must therefore consider the exploited “non-cereal” grasses more thoroughly. The project aims to address these research gaps by (1) investigating the association of potential arable weeds with unmanaged wild cereal habitats, (2) analyse the stable carbon and nitrogen isotope ratios of the different grass taxa in order to test whether these signatures significantly differ between habitats and (3) test the harvesting efficiency of medium- to large-seeded wild grasses in relation to the wild cereals. The harvesting experiments will also show whether unwanted “weed seeds” become incorporated into harvests from unmanaged stands, falsely indicating cultivation activities. Finally, we will combine these investigations with an analysis of the functional traits of the recorded species, linking taxonomic and structural variability to environmental gradients.

Keywords: archaeobotany,stable isotope analysis,aceramic neolithic,origins of cultivation,near east