Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identifying and exploiting SLC39A14 regulatory mechanisms for the future development of therapeutics (SLC-Mn-HMNDYT2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 214344.72
EU funding (EUR): 214344.72
Participants: 1
Project status: SIGNED

Solute carriers (SLCs) are membrane proteins that mediate the transport of biological and inorganic molecules. SLC39A14 regulates the transport of manganese (Mn) into primarily liver and intestinal cells from the blood. Bi-allelic loss of function (LOF) variants in SLC39A14 lead to an accumulation of blood Mn, which travels to the brain, causes significant deficits in motor function, eventually leads to the patients being non-ambulatory. Accordingly, these patients are diagnosed with Hypermanganesaemia with dystonia 2 (HMNDYT2) and are treated with Mn chelating agents. This treatment removes excess Mn from the blood; however, the five to eight day every four week treatment regime is impractical, and the treatment fails to alleviate clinical phenotypes in many cases. For this reason, new therapies must be developed. Many LOF variants lead to mislocalization of SLC39A14 away from the plasma membrane, similar to how CFTR mutations induce loss of function. Interestingly, the recently FDA-approved drug "Trikafta" restores CFTR function by relocalizing it LOF variants to the plasma membrane. This method of action could serve as the basis for future HMNDYT2 therapies, but the regulatory landscape surrounding SLC39A14 gene expression, proteostasis, and trafficking is currently unknown. To address this significant gap in knowledge, we will identify genes that regulate SLC39A14 and could be future targets for HMNDYT2 therapies. To do this, we will first characterize the mislocalization of all 15 known SLC39A14 LOF variants in the population using microscopy and flow cytometry. We will then engineer HepaRG liver cells to express WT- and mutant-SLC39A14-EGFP at the endogenous SLC39A14 locus and perform a FACS-based whole genome CRISPR KO screen to identify genes that, when mutated, restore mutant-SLC39A14 levels at the plasma membrane. Lastly, we will validate our findings in other liver and intestine model systems, setting the stage for future therapeutics.

Keywords: cell line engineering,manganese,solute carriers
Print4Life – Advanced Research Training for Additive Manufacturing of the Biomaterials and Tissues of the Future (Print4Life)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,Spain,Ireland,Portugal,Germany,Finland,United Kingdom,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4884948.46
EU funding (EUR): 4630389.84
Participants: 14
Project status: SIGNED

The programme will deliver early-stage researchers with the necessary innovative technical and entrepreneurial training to provide advances in the understanding of the possibilities and limitations of additively manufacturing advanced biomaterials as well as 3-dimensional cell-containing models for advanced biological studies. These researchers will gain the necessary subject-specific, intersectoral knowledge and the wider innovation skills demanded by industry with which to deliver timely and cost-effective solutions to some of Europe’s most imminent healthcare problems. The career options for these researchers are wide-ranging, including academia as well as regulatory affairs, commercial R&D, management and policy, all of which comprise a significant leadership and innovation component. This aim will be achieved by a unique combination of hands-on research in leading research centres, industry secondments and wide-ranging workshops covering technical and transferable skills. Additive manufacturing, including bioprinting, and its possibilities for providing patient-specific solutions to tissue defects as well as new material performances and enhanced models for biological testing has received global attention due to its disruptiveness. This means that we are still learning and it is important to educate for this. It provides immense possibilities for the global economy, and for a sustainable world in particular, allowing for less material use as well as sustainable solutions to healthcare issues and increased resilience at the European level. In this program we will focus on degradable, antibacterial materials and tissues in light of the alarmingly increasing antimicrobial resistance worldwide. Here new materials as well as new test methodologies will be researched, while ensuring that we educate for the future in the disruptive technology that is additive manufacturing.

Keywords: additive manufacturing bioprinting biomaterials antibacterial degradable
Advanced imaging system for Medical Applications (AMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-11-01
End date: 2025-12-31
Duration (months): 26.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 3
Project status: SIGNED

i-TED is a gamma-ray imaging system that was fully developed and successfully applied for nuclear astrophysics experiments at CERN n_TOF in the previous HYMNS ERC CoG. i-TED was designed for highest possible detection sensitivity, and it is also characterized by its modularity, portability and low sensitivity to neutron-induced backgrounds. These characteristics make the developed system potentially very attractive for several emerging applications in health and life science. Indeed, Compton imagers are expected to provide a breakthough innovation potential in the fields of i) ion-range monitoring in hadron therapy, ii) intraoperative Radio-Guided Surgery (RGS), iii) dose-monitoring in boron-neutron capture therapy (BNCT), and iv) theranostics (radioisotopes that serve for both therapy and diagnostics). Thus, the aim of this POC proposal is to perform first proof-of-concept measurements with readily available i-TED Compton cameras for demonstrating their applicability and advantages in two of these fields: (ii) intraoperative RGS and (iii) neutron dose assessment in BNCT. We also aim at addressing the corresponding technical-readiness levels (TRLs) for each application, which seems the most convenient approach for an efficient transfer of the developed technology towards society.
European Community of Practice supporting Hubs for Circularity (H4C ECoP) (H4C ECoP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Coordination and support actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Portugal,France,Belgium,Germany,United Kingdom,Netherlands
Call: Hubs for Circularity European Community of Practice (ECoP) platform (Processes4Planet Partnership) (CSA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 1658186.25
EU funding (EUR): 1658186.25
Participants: 8
Project status: SIGNED

Hubs for Circularity (H4C) are to be the European lighthouses of resource efficiency: through implementing best practice in industrial and urban symbiosis (I-US), the H4C are intended to achieve a step change in circular utilisation of resources and GHG emission reductions within given geographic areas. The European Community of Practice (ECoP) builds on and brings together ongoing work and expertise on H4C and I-US, initially supporting the H4C demonstrations funded under Horizon Europe. This project will develop both the ECoP network of stakeholders (commencing with funded H4C demo projects) together with an information and knowledge platform to enable stakeholders to take action. By creating awareness and fostering knowledge sharing between regions/cities and their industries, the H4C Platform will provide the tools and the evidence base for the approach to be adopted widely across Europe. A sustainable business model for deployment of the toolkit and services developed under the project will ensure the H4C ECoP is maintained well into the future. This consortium led by ISQ not only includes world leaders in the field (experienced in delivery, training, stakeholder engagement, models and methodologies) but also has the specific committed support and participation of many of the European bodies (those representing regions, cities, industry, educational institutions etc) that are needed to both disseminate the project outcomes and initiate implementation. Working closely with its sister consortium H4C-Europe, the H4C ECoP consortium is confident of delivering an ECoP and H4C platform that will achieve the target of greater circularity and carbon neutrality through profitable actions that also benefit communities/civil society.

Keywords: industrial symbiosis
Creating and Stabilizing Quantum Resource Phases of Interacting Quantum Matter: The Equilibrium and Nonequilibrium Routes (CondmatQTech)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

We propose a program for creating and protecting quantum correlations and coherences responsible for the supremacy of quantum technologies, by identifying their optimal embodiment in many-body states of quantum matter in and out of equilibrium. Our vision is to connect various stable phases of quantum matter, especially the non-equilibrium ones, with perturbatively connected families of resourceful states, and thus tie the stability and creation of those phases with those of the resources. Our concrete formulation is based on physics insights of the symmetry, localization property, and dynamics of many-body systems under coherent external drive. For state creation, we will employ quantum annealing based protocols combined with our understanding of quantum phase transitions between simple phases (e.g., ferromagnetic) and those with useful correlations like long-range entanglement (e.g., spin liquids). The approach promises to evade notorious classical barriers. For example, the “sign problems” in simulating highly frustrated ground states without disorder can be bypassed by our protocol. For protecting delicate quantum states, we propose a novel approach of combining dynamical stability owing to the suppression of many-body chaos by a periodic drive and Many-Body Localization. Our program will facilitate and expedite the advent of quantum technologies which are expected to revolutionize every aspect of human life and society. On the fundamental side, the project will uncover new territories in the field of quantum condensed matter, especially that stabilized out-of-equilibrium. This will initiate new research perspective to the field of theoretical many-body physics, and endow the nascent field of non-equilibrium coherent quantum matter with a direct technological (and hence economic) relevance.

Keywords: non equilibrium dynamics,quantum phases,floquet systems,many body localization,quantum annealing,quantum information,quantum resources,entanglement,spin liquid
A scalable semiconductor quantum computation platform based on Ge hole spin-qubits in rhombic quadruple quantum dots in strained Ge/SiGe (DEMETER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

I propose a 24-month MSCA Postdoctoral Fellowship in experimental condensed matter physics to overcome limitations in coherence time, single-gate operation frequency, and scalable readout associated with challenges in realising quantum computers. DEMETER builds on the complementarity of my strengths, the leading fabrication expertise and infrastructure at my Host, Tyndall National Institute, and the know-how in quantum information processing afforded by a secondment at the high-potential UK SME Quantum Motion. I will use Ge as an emerging quantum material platform to realise Ge-hole spin qubits in strained Ge/SiGe heterostructures and gate-defined RQQDs formed in the underlying Ge. DEMETER aims to demonstrate a beyond state-of-the art scalable qubit platform using the emergent architecture of Rhombic Quadruple Quantum Dots (RQQDs) and the Ge material platform. Using this novel architecture and exploiting advances in fabrication processes, rf-based novel techniques – that is rf single-electron transistor (RF-SET) and gate-based sensing for qubit readout will be implemented offering scalability through integration of both the qubit realization and control readout. My specific science and technology objectives are to achieve advances in the coherence time, fast qubit operation and fast readout, and to contribute towards the scalability of quantum microchips. My career development will benefit from the supervision of Dr Giorgos Fagas, an established leader at Tyndall, the Irish quantum technologies community and the EU landscape, and the research expertise in processing Ge nanostructures of Drs Duffy and Petkov. During my 2-month secondment, I will be supervised by Dr. Fernando Gonzalez-Zalba who is a leading researcher in gate-based sensing reflectometry. The goal of the Fellowship matches the urgent need to support the EU Quantum Technologies flagship and foster leading expertise in quantum computing.

Keywords: quantum dots,quantum computing,hole spins,ge sige heterostructure,rf reflectometry
Behavior, Network, Market and Policy Dynamics in Multi-Modal, Multi-Layer and Multi-Class Air and Rail Transport Systems (3MARS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999816.0
EU funding (EUR): 1999816.0
Participants: 1
Project status: SIGNED

The long-distance transport market is currently experiencing rapid changes and innovative services and policies are fundamentally reshaping how we travel. The discrepancy between the relevance of long-distance travel for emission reduction policy goals and the lack of related knowledge to support the design, planning and policy making of long-distance transport systems hinders the development of successful pathways. In order to understand, forecast, devise policies and evaluate developments related to long-distance travel, there is an urgent need for new paradigms which consider strategic behaviour, network development strategies, policy trajectories and co-evolution of markets where revenue management and coopetition are prevalent. This requires developing comprehensive and cutting edge methods for designing and assessing policy interventions by integrating behavioural, network development and market dynamics, for which the PI is well-positioned. This research program develops and tests theories and models of transport systems in the uncharted domain of long-distance transport markets with Multi-layer, Multi-modal and Multi-class Air and Rail Systems (3MARS). 3MARS will unravel crucial behavioural aspects; develop novel models for the assignment of multi-class flows for a multi-layer multi-modal network; conceptualize and operationalise the market relations and dynamics between supply and demand and amongst service providers and the evolution thereof; develop network design and revenue management techniques in competition-collaboration settings; design and assess supply- and demand-side policy interventions, and the interactions between all of those system components and phenomena. The proposed program will result in a series of theoretical and methodological breakthroughs in the field of transport modelling and, methodological and empirical contributions in the fields of travel behaviour, environmental and sustainability policy, and network and market.

Keywords: long distance transport,network assignment,travel behavior,transport policy,transport modelling
AI-based-technologies for trustworthy solutions against disinformation (AI4TRUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Spain,Romania,Poland,Switzerland,United Kingdom,France,Estonia,Germany,Belgium
Call: AI to fight disinformation (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2023-01-01
End date: 2026-02-28
Duration (months): 38.0
Total project cost (EUR): 5950682.5
EU funding (EUR): 5950682.5
Participants: 19
Project status: SIGNED

Increasing evidence shows that disinformation spreading has non-negligible impact on our society at individual and collective levels. From public health to climate change, it is of paramount importance to timely identify emerging disinformation signals such as content from known unreliable sources and new narratives, especially from online social media, to provide media professionals and policy makers with trustworthy elements to extinguish disinformation outbreaks before they run out of control. However, monitoring and analyzing large volumes of online content is well beyond the capacity of human ability only. In fact, regardless of the socio-psychological and behavioral reasons behind information forging, the rate at which disinformation is produced is much larger than the rate at which it can be analyzed and its effects adequately mitigated. AI4TRUST will provide a hybrid system, where machines cooperate with humans, relying on advanced AI solutions against advanced disinformation techniques to support media professionals and policy makers. Our system will monitor, in nearly real time, multiple online social platforms, filtering out social noise and analyzing multimodal (text, audio, visual) content in multiple languages (up to 70% of coverage in EU) with novel AI algorithms, while cooperating in an automated way with an international network of human fact-checkers who will be periodically triggered and who will frequently provide validated data to update our algorithms. The resulting quantitative indicators, including infodemic risk, will be inspected under the lens of social and computational social sciences, to build the trustworthy elements required by media professionals to create customizable and reliable data reports. We expect that the AI4TRUST's system, based on a human-centred approach to technology development that is aligned with European social and ethical values, will be integrated in the standard toolbox of data analysts working on disinformation.

Keywords: complex networks,infodemics,multimedia analysis,social phenomena
LEVERAGING AFRICAN GENOMIC SEQUENCING PLATFORMS FOR PUBLIC HEALTH IMPACT (NGS4PublicHealth)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: South Africa,United Kingdom,Ethiopia
Call: HORIZON-JU-GH-EDCTP3-2022-OA2 Collaboration between GH EDCTP3 and the contributing Partner Bill & Melinda Gates Foundation: Genomic epidemiology for surveillance and control of poverty-related and emerging/re-emerging infections in sub-Saharan Africa (HORIZON-JU-EDCTP3-2022-GH-Epidemiology-IBA, 2022)
Start date: 2022-09-08
End date: 2026-07-07
Duration (months): 46.0
Total project cost (EUR): 19507092.65
EU funding (EUR): 50000.0
Participants: 4
Project status: SIGNED

The objectives of our proposed work are well aligned with the goals for the collaboration between the Global Health EDCTP3 and the Bill & Melinda Gates Foundation (BMGF) joint undertaking under Topic GH-EDCTP3-2022-CALL1-02-02. The participants listed in this proposal are key members of the Africa Pathogen Genomics Initiative (Africa PGI) and the Global Health Network (tGHN). The participants will leverage these two existing platforms to provide access to expertise and resources in genomics (from AfPGI) and clinical trials research and data science (from tGHN) to EDCTP grantees in genomic epidemiology (hereafter referred to as EDCTP grantees) to be selected under Topic GH-EDCTP3-2022-CALL1-01-03. Specifically, the grant funds requested for this project will fund one full-time project manager dedicated to supporting coordination activities between EDCTP grantees and the participants. The project manager will be based at University of the Western Cape and will work closely with Africa CDC (While Africa CDC is not a formal participant in this proposal, (not among the legal entities receiving direct funding) they are core stakeholders and leaders in the project, notably via collaboration with ASLM.) Jointly, these platforms combined with the coordination activities described in this proposal will support as relevant EDCTP3 grantees to implement use-cases in genomic epidemiology and advance the stated objectives above. Over the past four years, we have seen genomic sequencing programs significantly advance and expand in Africa, helping demonstrate that the goals outlined within this project are measurable, verifiable, and realistically achievable.

Keywords: data standards,ngs analysis,disease outbreaks