Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Emergent Properties to Improve Climate projections over Europe (EPICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The North Atlantic Ocean has been shown to be 1) potentially predictable up to a decade ahead, 2) important in the predictability of other regions/indices e.g. European temperatures, Atlantic hurricanes, Sahel rainfall, and, 3) crucial to the manifestation of longer term climate change involving the large-scale ocean (e.g. the AMO/AMV; Atlantic Multidecadal Oscillation/Variability). Nonetheless, similarly to the widely considered “equilibrium climate sensitivity” (ECS; the long term temperature change in a climate model given a doubling of carbon dioxide levels), the spread in projections over the North Atlantic has remained large throughout IPCC (Intergovernmental Panel on Climate Change) assessment reports. In this project, we will investigate the causes of the spread in climate projections of the North Atlantic across IPCC-CMIP6 to derive emergent constraints that will allow better projections of climate change in Europe: We will (1) investigate the specific mechanisms of North Atlantic change in these models and compare with historical observations. This will lead to (2) testing how these comparisons are sensitive to the model formulation (via targeted experiments in two comparable state-of-the-art CMIP6 models from European institutions that use the same underlying ocean model). Finally, this will allow us to (3) derive emergent constraints to narrow the spread in CMIP6 projections. This project will combine the statistical power of the CMIP6 archive with the detailed process understanding obtained from targeted sensitivity experiments conducted within a coordinated ocean framework. Our goal is twofold: To understand the mechanisms behind climate change projections in the North Atlantic/Europe and to use this knowledge to derive emergent constraints with which to narrow the uncertainties in these important projections. EPICE: Emergent Properties to Improve European Climate Estimates

Keywords: climate change,atlantic,ocean,dynamics,variability,decadal,projections,predictions
Engineered Nanoparticles Targeting Hair Follicles for Alopecia Areata Treatment (EngiNano-HF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Alopecia areata (AA) is a common autoimmune disorder resulting from damage of the hair follicle by cytotoxic T cells and characterized by non-scarring hair loss. This project intended for preventive treatment AA brings together a highly motivated, experienced, and talented Researcher (Dr. Matías Picchio), with a Polymer Chemistry background in biomaterials, hydrogels, and nanoparticle synthesis and properties improvement methodologies for biomedical applications, and POLYMAT, an innovative technological institute in the field of development of biomedical solutions based on nanohydrogels for the controlled release of therapeutic substances. EngiNano-HF will focus on advancing the Experienced Researcher’s career through the development of the technology and manufacture stages of a new supramolecular polymer nanoformulation for the successful management of Janus kinase-inhibitors to prevent AA and associated complications. Under the supervision of Prof. M. Calderón, a globally recognized researcher, EngiNano-HF will proceed in a stepwise fashion using cutting-edge methodologies to prepare and physicochemically characterize the polymer nanocarriers. The effect of the nanocarrier size, surface chemistry, surface charge, and mechanical properties on the hair follicle penetration and follicular delivery will be evaluated in porcine ear skin ex-vivo models. The most promising formulations will then be validated on a pre-industrial scale. Three highly experienced teams RPT, CRC, and i+Med company will complement each other to meet the multidisciplinary expertise needed for EngiNano-HF. This proposal is designed to allow the applicant to expand his research field significantly by receiving high-quality training-through-research and developing a new set of transferable skills. Moreover, with the aim of achieving the highest possible social, industrial, and academic impact, this proposal covers multiple aspects related to exploitation, dissemination, and outreach activities.

Keywords: hair follicle,skin diseases,alopecia areata,janus kinase inhibitors,pre industrial product development
Competence Centre for the Conservation of Cultural Heritage (4CH)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Coordination and support actions
Countries involved: Italy,Italy,Italy,Spain,Italy,Ireland,Italy,Cyprus,Switzerland,Romania,Greece,Greece,Belgium,Moldova, Republic of,Belgium,Bulgaria,France,France,Netherlands,Portugal
Call: European Competence Centre for the preservation and conservation of Monuments and Site (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2998208.75
EU funding (EUR): 2998208.75
Participants: 21
Project status: SIGNED

The 4CH project will design and prepare for a European Competence Centre (CC) on the Conservation of Cultural Heritage which will work proactively for the preservation and conservation of cultural heritage (CH). The project aims to start implementing the structure, organization and services of the CC which will operate as a virtual infrastructure providing expertise, advice and services using state-of-the-art ICT with a special focus on 3D technology. A Strategic Advisory Board, including representatives of major national and international CH bodies, will be established to advise on cultural, scientific, technological, financial, strategy and policy areas. 4CH will design and implement the ICT infrastructure of the CC, based on a Cultural Heritage Cloud, compliant with the EOSC vision, to provide an open collaborative digital space for cultural heritage conservation giving access to repositories of data, metadata, standards and guidelines. Access to High Performance Computing service providers will be supported. The core results of 4CH work will comprise of: • a holistic interdisciplinary approach to state-of-the-art 3D documentation of monuments and sites for conservation, preservation, access and exploitation • guidance on policies and strategies • a catalogue of well-documented standards • an inventory of software and tools • guidelines for data acquisition, management and storage • a set of success stories on advanced digitization • advice on funding opportunities • training and education plans for professionals and managers • communication and dissemination of 4CH results • a complete business model and a sustainability plan for the Competence Centre. 4CH will foster the implementation of actions to substantially increase the number and the quality of digitized sites, documents and monuments.
DNA Origami for drug delivery (VECTORIGAMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The main objective of this project is to produce innovative DNA self-assembled nanostructures with the goal of evolving new approaches for drug delivery. The properties of the DNA nanostructures will be tuned by introducing new elements into the nanostructures improving their versatility and structural integrity. This project will aim to: • build and characterise DNA nanostructures using long oligonucleotides of biological production; • add different elements to the nanostructures, such as gold nanoparticles and proteins to the nanostructures to tune the respective intrinsic and structural properties; • develop new strategies to simplify the assessment of the integrity of nanostructures using fluorophores; • apply the newly developed nanostructures to assemble a delivery system for doxorubicin. This project will result in a synergy between the applicant’s particular profile and the high quality of the host institution. The applicant has experience in different sets of scientific areas such as fluorescence and nanotechnology as well as a background in molecular and cell biology. Complementarily, the host institution, the Department of Neuroscience at Karolinska Institutet, and Björn Högberg’s laboratory in particular, will provide the necessary knowledge on DNA nanotechnology. Högberg’s group has recently established itself as one of the leading DNA-nanotechnology labs in Europe with high-impact publications in the field.

Keywords: dna origami,gold nanoparticles,fluorescence,doxorubicin,drug delivery
Spatio-Temporal Representation on Neuromorphic Architecture (STRoNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-26
End date: 2020-10-25
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The latest achievements in artificial intelligence and neural networks, especially deep neural architecture in large-scale neuromorphic hardware implementation such as SpiNNaker, and in cognitive robotics and neurorobotics, with the widespread use of robots such as iCub and the latest Pepper platform, provide the opportunity to significantly advance our understand human cognition and brains and to reach human-level artificial intelligence. One of the key success factors in deep learning is its hierarchical structure inspired by biological processes in the primate visual cortex, as with convolutional deep networks able to learn rich representations. They are grounded in optimization methods with high precision for training may consume large training datasets and computational resources to learn complex tasks. That gives human level performance in static image recognition but raises adaptation issues. SpiNNaker is a neuromorphic computer architecture in massively parallel computing platform based on spiking neural networks (SNNs) in which neurons communicate by temporal code. The aim of STRoNA (Spatio-Temporal Representation on Neuromorphic Architecture) is to define the technology that will map a computational architecture onto neuromorphic computing circuits, hence to develop a cognitive model with spatio-temporal representation and learning algorithm for humanoid robots. The principal research objectives of the project are: (i) to investigate which spatio-temporal representations of spikes (or neural action potentials) can be used to achieve human level performance on visual perception; (ii) to develop a novel method to process spatio-temporal representation on a neuromorphic architecture to enable learning in online and interactive contexts; and (iii) to validate and adapt the developed system in real world robotics applications.

Keywords: cognitive robotics,neural networks,neurorobotics
Principles of Musical Structure Building: Theory, Computation, and Cognition (PMSB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-12-31
Duration (months): 82.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Music is a central human trait across all cultures and historical periods, involving a great rich variety of parameters, cognitive processes, and forms of structure building. The proposed project aims at advancing the understanding of human cognition and, specifically, the capacity to represent and process complex auditory sequences and syntactic structures by exploring the rich potential of music perception. Building on the PI’s previous work, this interdisciplinary research programme will be divided into three core strands: (A) The theoretical strand will be devoted to the investigation of formal principles that govern musical syntax and structure building in Western and non-Western music. Many current approaches share the expressive power of (tree-based) context-free grammars and are mostly confined to harmonic syntax only. Therefore, they face difficulty in expressing certain crucial syntactic phenomena in music. To address this lacuna, the theoretical strand will develop a novel unified theory of musical syntax that exceeds context-free complexity and reconciles harmonic structure with the constraints of voice leading within a single coherent framework. (B) Addressing the lack of machine-readable corpora in music research, a large corpus of digitized syntactic analyses will be compiled and published in the context of the project’s computational strand. Further, the unified syntax theory will be implemented based on a generalized parsing approach and graph grammars, and trained and evaluated using the analytical corpus. (C) The formal framework developed in (A) entails specific predictions about mental representations of musical structure that will be empirically tested in the experimental strand of the project. Particular focus will be on aspects of nonlocal dependency relations, learnability, revision, and tension. The outcomes of the project will make a significant contribution to both the field of music cognition and to the cognitive sciences in general.

Keywords: music cognition,syntax,corpus analysis,hierarchical processing,recursion,cross cultural analysis
Heating Electric-fields in a Plasma CVD reactor to Heighten Ability to grow Eeco-friendly and Sublime Type IIA Diamonds (which are Unique Stones) (HEPHAESTUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Diamonds form deep inside the Earth and they require extensive resources and time to discover. Naturally occurring diamonds can be found through open-pit or underground deep-earth mining or in riverbeds and ocean floor. Diamonds have fantastic properties allowing various tech and high-tech applications in the industry. They can also be used in the luxury business for their beauty, quality, cut and colours. But mined diamonds are a finite resource considering the extreme and rare occurrence of natural surroundings in which it can be formed so that the whole diamond industry now faces depletion of raw materials. DIAM CONCEPT leverages 30 years of research in the fields of plasma physics at CNRS LSPM related to diamond growth in laboratory. Growing diamonds in lab consists in placing small diamond seeds in highly controlled environment where the diamonds grow layer-by-layer. Plasma enhanced Chemical Vapor Deposition is based on high temperature and low-pressure whereby the plasma, generated by excitation of the gases through microwaves activation, leads to transformation of carbon containing species into diamond. DIAM CONCEPT is pushing forward the state of the art so as to be able to grow thick diamonds of the purest form known to man. The technology is based on a non-equilibrium microwave plasma-activated chemical reaction process in a large resonant cavity operating at 915 MHz. This process allows to grow colourless >VS1 Type IIA diamonds and adresses the finest jewellery market. Our diamond will be branded as symbol of modern love by representing the incredible progression of technology. DIAM CONCEPT ambitions to become a leading manufacturer of lab-grown diamonds for jewelry and we have already settled partnerships with 6 top jewellers that are to be enlarge to 10 top jewellers. On the opposite to mined diamonds, our lab-grown diamonds are ethical, respective of environment, have a low carbon impact (around 80 kg/carat), guarantee of origin and cost-efficient.

Keywords: diamond,diamond growth,chemical vapor deposition,plasma physics,jewelry,gemstones,inorganic materials,process
Integration of high resolution -OMICS datasets towards personalized therapy in bladder cancer (TheranOMICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 116250.0
EU funding (EUR): 116250.0
Participants: 1
Project status: CLOSED

TheranOMICS Project aims at the recruitment of a highly-qualified research Associate to support the Innovation Business Idea of Mosaiques diagnostics GmbH (MOS). The Associate is expected to have expertise in statistics, computer science and biology. The objective is the integration of high resolution bladder cancer (BC) –omics datasets that are available at MOS to establish molecular profiles which can predict disease outcome and treatment response. The tasks include application of state-of-the-art bioinformatics tools in the development of two predictive tools that together will be offered as a companion test to assist patient stratification and predict response in BC drug development. The first tool will be based on molecular features associated with the clinical status and will enable the stratification of BC patients to those with the higher probability to progress. The second tool will be built on molecules/biomarkers associated with drug response and will enable to prediction of success of chemotherapy, as a test case study. MOS Business Innovation Idea is the development of the above predictive tools, to be served as a "business-to-business" product for pharmaceutical companies developing Bladder Cancer (BC) drugs. The expected outcome is the improved stratification of BC patients and the increased efficacy of new therapeutic agents. The benefit for the customers (Pharmaceutical Industry) is the reduction of the number of investigated subjects, time requirement and cost of clinical trials. The benefit for MOS enterprise is the opening of new marketing possibilities and the positioning in the Market of Pharmaceutical Industry. As a secondary aim, we target implementation of the tools for BC Patient management, aiming at improved, personalized intervention to prolong patients’ lives and increase their quality of life. Thus, TheranOMICS aims beyond the one-year period of INNOSUP support and provides perspectives for the Associate for a long-term employment.

Keywords: systems pharmacology,treatment response,proteomics,bladder cancer,systems biology
Printing of Ultra-Thin, Flexible Perovskite Solar Cells and its Commercial Application (PIPER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The impact of buildings to European final energy consumption has been assessed at 40%, making the building stock responsible for 36% of CO2 emissions. The reduction of energy consumption in buildings is the focus of the European 2020 strategy. EU’s essential policy instruments that encourage energy efficiency, retrofit measures and renewable production are: the Energy Efficiency Directive (EED), the Energy Performance of Building Directive (EPBD and EPBD recast) and the Renewable Energy Directive (RED). One of the major initiatives promoted by the EPBD recast is the implementation of nearly zero energy buildings (NZEBs) as the building objective from 2018 onwards. In the US, as well, several states’ strategic plans stipulate that all new residential buildings must be zero-net-energy (ZNE) by 2020, all new commercial buildings - by 2030, and 50% of existing commercial buildings must be retrofitted to ZNE by 2030. However currently available technologies pose challenges to reaching these objectives in cost-effective way. As an example, photovoltaic devices which bring high hopes and expectations to NZEBs, can currently only cover roofs, not allowing to optimally use the majority of building surface. They only generate energy from direct natural light and cannot be used on existing buildings without the need of severe structure modifications. Similar challenges (compliance with regulations, search for optimal efficiency-cost ratio, need for constant performance improvement while maintaining aesthetic features) are also faced by many other industries (automobile, aeronautics, consumer goods – electronics, clothing, etc.) Saule Sp. z o. o. (Saule Technologies) aims to address these challenges by introducing the first-on-the-market perovskite solar cells (PSC) which are efficient, flexible, semi-transparent and inexpensive solar panels.

Keywords: photovoltaics,perovskites,perovskite solar cells,renewable energy sources