Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Role of Groups in Complex Disagreement (DISAGROUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-08-06
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The research project “DISAGROUP – The Role of Groups in Complex Disagreement” will investigate the phenomenon of complex disagreement in society from a philosophical perspective. Social epistemology has been mainly devoted to the study of peer disagreement (the kind of disagreement among individuals who share the same evidence and intellectual capacities). However, real-life disagreements such as long-standing religious, political or economic disagreements have a much more complex structure: the involved parties are not normally individual epistemic peers but groups that do not possess the same evidence or intellectual resources, they involve a lot of claims and are usually sustained not for the sake of knowledge but by elements such as faith, hate, intolerance or distrust. DISAGROUP aims to fill a gap in the philosophical literature by giving a general account of the structural elements that make most real-life disagreements so complex and difficult to understand, with a particular focus on the role played by groups in sustaining complex disagreements. In particular, DISAGROUP will address four main research questions: (1) Are the beliefs and other attitudes that ground complex disagreements beliefs and attitudes of groups with their own distinctive agency or by contrast of individuals that merely happen to believe the same thing? (2) Is complex disagreement better characterized in terms of belief or alternatively in terms of acceptance? (3) Can complex disagreement be characterized (at least partially) in terms of a difference in epistemic virtues among the disagreeing parties (groups) and, if so, what kind of virtues are they? (4) What is the rational response to complex disagreement? More specifically, does complex disagreement rationally compel groups to revise their beliefs or joint acceptances or does it also compel them to become more intellectual virtuous?

Keywords: philosophy,social epistemology,virtue epistemology,disagreement,groups
Ultrasonic System for Antifouling Protection of Ships (ULTRABOAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

75% of imports and exports and 37% of the internal trade of the EU takes place through seaports. From Delco TS, we envisaged UltraBoat as a durable and reliable solution to avoid the formation of fouling (bio-fouling) in ships (attachment of marine animal and plants to the surface of underwater parts of the vessel). This may seem a minor problem but every ship owner knows about the importance of making an adequate choice of antifouling treatments due to associated operating costs. The formation of fouling on ships increases the surface roughness of the hull, which leads to increased fuel consumption. After six months, a ship without an appropriate antifouling system can suffer a 40% increase in fuel consumption to maintain normal speed. Antifouling also requires specific maintenance because current solutions are not durable enough. Nowadays the ship owners need to periodically re-apply antifouling coatings. Apart from the fact that this coatings are in constant surveillance due to the release of harmful substances, the process requires dry docking the ship (at least every 5 years) for a period of usually 10-12 days. Although antifouling treatment is only a part of this maintenance, it has a big impact on the total operating costs of transport ships. Annual costs resulting from fouling represent more than 350,000€ for a single vessel of medium size (90-120.000 of Gross registered tonnage).

Keywords: biofouling,ultrasound,ship
European Liquid Biopsies Academy - Towards widespread clinical application of blood- based diagnostic tools (ELBA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Germany,Italy,Spain,Italy,Belgium,Bulgaria,Sweden,France,Netherlands,United States,Netherlands,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-09-30
Duration (months): 57.0
Total project cost (EUR): 3727722.96
EU funding (EUR): 3727722.96
Participants: 21
Project status: CLOSED

Liquid biopsies have been heralded as a game changer in cancer management, with blood tests offering a minimally invasive, safe, and sensitive alternative or complimentary approach for tissue biopsies. Blood represents a rich source of information through which solid cancers (and their subtypes) can be detected, identified and classified, and matched to a specific therapy. However, despite the potential of individual approaches, the promise of liquid biopsies has not yet materialised in the clinic. Widespread deployment requires creative next-generation researchers with an innovative mindset with access to a unique toolbox, including medical know-how, molecular diagnostics expertise (from health economics to regulatory), and statistical/bioinformatical proficiency. Currently, there are no comprehensive training programmes to address this need. To move the promising liquid biopsy technology out of its infancy, the research programme and educational curriculum of the European Liquid Biopsy Academy (ELBA) will cover the entire value chain of diagnostics development and integrate all required disciplines and sectors. ELBA will educate 15 Early Stage Researchers (ESRs) with the skills to circumvent the obstacles currently hampering effective development and commercialisation of liquid biopsy approaches. By creating a sustainable network to foster long-term multidisciplinary relationships and communication networks with various stakeholders we aim to accelerate clinical translation of these blood-based diagnostics. Most importantly, we have designed a well-balanced training programme to provide excellent career opportunities for the 15 ELBA ESRs. this includes training on state-of-the-art technologies and tools; bioinformatics, biostatistics and mathematical modelling; health economics and health technology assessment; diagnostic test development (including intellectual property and regulatory affairs); transferable skills (including leadership) and patient inclusion.

Keywords: cancer,liquid biopsies,tumour educated platelets,circulating tumour dna,extracellular vesicles,exosomes,circulating tumour cells
A bio-identical and non-animal replacement for the quality control reagent of pyrogen testing in the medical and pharmaceutical industries. (LimuleX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A pyrogen is a fever inducing substance when introduced or released into the bloodstream, typically produced by a bacteria. Bacterial endotoxins are lipopolysaccharides present in the cell walls of Gram-negative bacteria. Pyrogen testing is a fundamental necessity in quality control for product safety in the regulated biomedical industries. For example, parenteral preparations have to be pyrogen-free because administration of pyrogens may induce fever, shock or even death. The severity of the adverse reaction depends on the concentration and biological activity of the respective pyrogen. The gold standard and de facto industry norm for pyrogen tests is a reagent called LAL (Limulus Amoebocyte Lysate). However, for the past 60 years, the sole source for making LAL has been the blue blood of the Atlantic Horseshoe Crab. Even at current harvest rates, the product is unsustainable. Demand is forecast to more than double in the next 5 years. Moreover, there are longstanding challenges in the upstream side of the LAL supply chain. Sothic produce a bio-identical LAL using proprietary cell technology. This removes the declining animal source from the equation, modernizing the outdated supply chain and making a better quality product. Sothic replace the use of unsustainable animal-derived reagents with scalable production of high-quality biomolecules.

Keywords: horseshoe crab,sustainability,sustainable harvesting,pyrogen test,cell technology,bioidentical
Understanding the mechanisms behind tree responses to drought-induced stress with increasing tree size (DISTRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-12-16
End date: 2022-12-15
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

Plants adjust leaf water potential and hydraulic conductance under drought through stomatal behaviour, reducing sap flow and protecting plants from extensive water loss and embolism. Due to the negative effect that vapour pressure deficit (VPD) and tree height have on canopy-scale water conductance (G), Darcy’s law predicts a decline in G due to the expected increase in VPD following climate warming, to which tall trees would be presumably more sensitive. Further work is thus needed to understand the effect that tree size has on tree response to increased VPD and drought. This project aims at (1) testing whether, at a given VPD, trees adjust different functional traits to compensate for the negative effect of height on G in (a) tropical forests and (b) at a global scale, and (2) describing the mechanisms behind these adjustments and the potential interactions with other functional processes that may impair tree response to drought stress with increasing size. We will first measure multiple functional traits (including sap flux, gas exchange and leaf and xylem water potential) on trees of different heights to test Darcy’s law predictions and evaluate the role that the trade-offs among traits play on enhanced vulnerability to drought with increasing tree size in tropical forests. In order to assess whether the studied mechanisms prevail across species and ecosystems, we will perform a global-scale analysis of sap-flow and, thus, G responses to VPD as a function of tree height using the sap-flux data from 159 species and nine different biomes gathered within SAPFLUXNET. This integrated analysis will provide a better understanding of the role that tree size plays in tree vulnerability to drought in the short (temporary physiological response) and long term (legacy effects), allowing the improvement of mechanistic models of tree response to climatic variability. Such information is essential to better simulate the impact that climate change may have on forest ecosystems.

Keywords: darcy s hydraulic corollary,drought,functional traits,sap flow,transpiration,tree height,vapour pressure deficit,water vapour conductance
The role of autophagy in presynaptic protein turnover (SYNPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Neuronal communication primarily occurs at synapses. Recent studies have suggested a key role for protein synthesis and degradation in the regulation of synaptic structure, function and plasticity by changing the abundance of select synaptic proteins in a spatially confined manner. Remodeling of the synaptic proteome is accomplished by, for example, regulated degradation via the ubiquitin proteasome system or by autophagy. Autophagy has been shown to modulate synaptic vesicle numbers and neurotransmission, yet its exact role in the regulation of synaptic function is poorly understood. The proposed project aims at the dissection of the role of autophagy in synaptic protein turnover. Using combined genetic, biochemical, molecular and cellular biology approaches as well as cutting-edge imaging in neurons I will identify presynaptic proteins that are regulated by autophagy and will define the contribution of autophagy to synapse composition and function. Furthermore, I will determine which mechanisms underlie the selective targeting of presynaptic proteins to the autophagy pathway. Taken together these studies will contribute fundamental knowledge about autophagy in neurons and will provide new insights for understanding how autophagy contributes to synaptic plasticity and protein degradation in health and disease.

Keywords: synaptic plasticity,presynapse,autophagy
Discrete Multi-physics modeling of hydrate blockage in pipelines (HYDROBLOCK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-02
End date: 2021-09-01
Duration (months): 18.0
Total project cost (EUR): 168700.32
EU funding (EUR): 168700.32
Participants: 1
Project status: CLOSED

Gas hydrates are crystalline compounds where a cage-like water structure surrounds an organic molecule such as methane. They often form in oil and gas pipelines, where they stick to the inner walls clogging the flow. When this happens, the blocked section of pipe needs to be cut out and replaced, resulting in long shutdowns of production. The oil and gas industry spends more than 200 million euros per year to prevent such blockages and industry sources estimate the total costs for prevention and lost production due to hydrates in the order of billions. Available commercial software packages generally only focus on the thermodynamics of hydrate formation, but recent scientific literature emphasizes the interconnected role of thermodynamics with heat transfer and hydrodynamics. To better understand this phenomenon and to devise techniques to control/minimize its effects, we aim to adapt a novel multi-physics methodology called Discrete Multi-physics and derive from it computational tools to study and predict hydrate blockage. Based on Discrete Multi-physics, we will set up a mathematical model that links thermodynamics, heat transfer and hydrodynamics and generate an Open Source software freely available to other academics and practitioners.

Keywords: multi physics,smoothed particle hydrodynamics
Fully controlled RTM tooling and high deposition rate ALM technologies for cost-effective and sustainable manufacturing of hybrid laminar wing demonstrator (HERON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,United Kingdom
Call: Development and manufacturing of innovative tooling for composite parts (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-05-01
End date: 2021-10-31
Duration (months): 30.0
Total project cost (EUR): 956725.0
EU funding (EUR): 926852.5
Participants: 2
Project status: CLOSED

The overall objective of HERON is to develop and manufacture a comprehensive set of innovative, cost-effective and sustainable tooling for RTM processes as well as the use of high deposition rate ALM technologies, aiming at improving the energy and resource efficiency of the manufacturing of a leading edge and trailing edge for integration on aeronautical demonstrator. To this end, four innovative technologies will be combined and demonstrated at operational environments in aeronautic sector reached TRL 6: A. Modular design for RTM tooling to facilitate leading edge parts demoulding and heating strategies, combining different heating systems in customized surfaces. B. Near real time process monitoring as path to control RTM process parameters (such us temperature) relying on in-mould sensors (thermocouples, strain and pressure gauges), external gauges (thermal cameras) and a control algorithm for thermal distribution. C. High deposition rate hybrid ALM for trailing edge production to reduce resources consumption, using resins specifically developed for aeronautical applications. D. Finally, a fully automated and high accuracy production environment for the manufacturing of the necessary tooling for the leading edge and the application of the ALM technologies for the trailing edge, could ensure an accurate integration on the hybrid laminar wing demonstrators and an easy reparation or modification of the RTM tooling and ALM parts These four innovative approaches can lead up to a direct 25 % of energy consumption reduction, 20 % of cost reduction and 30 % reduction in time cycle for the production of aeronautical structures. The project concept will address 100% tooling needed in the RTM and ALM processes, both for manufacturing and validating purposes, leading to a reduction of CO2 equivalent emission by up 30% linked to the Clean Sky 2 Programme High-level Objectives.

Keywords: modular design,process monitoring,high deposition rate alm,fully automated production environment
Shaping the European Migration Policy: the role of the security industry (MIGPSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Looking back to the last 20 years of EU migration management policy, it has become more and more palpable the growth and development of a security industry within a hybrid space, where European and non-European security forces operate alongside NGOs, humanitarian groups and international organizations, and where private security companies play a key role supplying technology, military equipment, hardware and intelligence services. The European Agenda for Migration already reflects the blurring of the lines between internal and external security, with policy outputs echoing the weight of the security industry. This project seeks to understand the increasing role of private security companies and the weight of the security industry in the way the EU migration management policy is shaped and produced. Later advances not only in security field in general, but also in the migration field in particular, illustrate that the market for security is continuously flourishing and a demand market is fed by evolving migration flows. In order to understand the level of influence of private security actors in the design of EU migration policy making, I will use process-tracing methodology to observe the changing pathways of migration policy process and understand when and why this changed has occurred.

Keywords: migration management,securitization,european border security,private security,surveillance
Non-Intrusive Flow distortion measurements within a Turbofan Intake (NIFTI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Netherlands,United Kingdom,United Kingdom
Call: Non-Intrusive Flow Field Measurement within a UHBR Intake (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2020-01-01
End date: 2023-10-31
Duration (months): 46.0
Total project cost (EUR): 2336394.75
EU funding (EUR): 2250000.0
Participants: 4
Project status: SIGNED

Short and slim aero-engine intake designs for very high bypass ratio configurations cause notable levels of unsteady distortions at the fan face especially under cross-wind or angle of attack operation during aircraft take-off. Such distortions can adversely affect the engine’s performance, operability, structural integrity and safety margin with potentially catastrophic consequences for the entire propulsion system. Current practices for aero-engine testing and certification rely on a low number of intrusive pressure measurements at the fan face to characterise the distortion levels. Given the known limitations of currently used methods (low spatial resolution, intrusive nature) the existing technologies are inadequate to reduce the risk on the development and certification of future novel systems. NIFTI aims to address this gap by demonstrating a non-intrusive technique to measure velocity fields across a plane located upstream of a large diameter fan of a high bypass ratio aero-engine which has never been achieved. This method will provide synchronous datasets across the measurement plane with at least one order of magnitude higher spatial resolution than current methods. The implementation will demonstrate a highly automated and flexible multi-camera system within a representative industrial test environment. A number of more advanced, non-intrusive measuring technologies will be assessed such as 3D PTV or Helium Filled Soap Bubbles (HFSB) to further enhance the outputs of the selected baseline solution. The experimental activities will be supported by numerical campaigns and advanced data processing and flow analysis methods that will be used to analyse the highly unsteady nature of the flow distortions that will be measured during NIFTI’s experimental campaigns. These outcomes will ultimately unlock the complex aerodynamics of closely coupled fan-intake systems and aid the development of novel design rules for future, stall-tolerant aero-engines.

Keywords: industrial wind tunnel tests,isolated intake testing,uhbr short intake,piv flexibility,wt productivity,fan distortion,pressure from piv,advanced data analysis,unsteady aerodynamics