Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimized oxidoreductases for medium and large scale industrial biotransformations (INDOX)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Spain,Denmark,Germany,Italy,Netherlands,Spain,Austria,Netherlands,France,Spain,Germany,Türkiye,Germany,Denmark
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 11337677.6
EU funding (EUR): 7825824.0
Participants: 16
Project status: CLOSED

The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a significant extent primarily due to lack of biocatalysts with the required selectivity, availability and compatibility with the rigorous process conditions. Selected industrial oxidation and oxyfunctionalization target reactions form the basis for the INDOX screening and optimization of new biocatalysts, including: i) Intermediates for agrochemicals/APIs; ii) Polymer precursors and functionalized polymers; and iii) Intermediates for dye-stuffs. The project flow comprises: i) Recovery of selective biocatalysts from the groups of heme-peroxidases/peroxygenases, flavo-oxidases and copper-oxidoreductases from fungal genomes and other sources; ii) Improvement of their oxidative activity and stability by protein engineering (using rational design, directed evolution and hybrid approaches combined with computational calculations) to fulfill the operational and catalytic conditions required by the chemical industry; and iii) Optimization of reaction conditions and reactor configurations (including immobilization technologies and new enzymatic cascade reactions). Finally the cost efficiency compared to chemical processing will be evaluated. The INDOX approach is supported by a highly-specialized consortium of SMEs, large companies and research/academic institutions. Production of the new optimized biocatalysts and their introduction into the chemical market will take advantage from the participation of the world-leading company in the sector of industrial enzymes, together with several chemical companies willing to implement the new medium- and large-scale biotransformation processes.

Keywords: agrochemicals biocatalysts cascade reactions computer simulation directed evolution dyes enzymes immobilization laccases mutagenesis oxidases oxyfunctionalization peroxidases peroxygenases polymers
Improving European aquaculture by advancing selective breeding to the next level for the six main finfish species (FISHBOOST)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Norway,Netherlands,Greece,France,Spain,France,Finland,United Kingdom,Italy,Czechia,France,France,France,France,France,Czechia,France,Spain,Spain,Czechia
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2014-02-01
End date: 2019-01-31
Duration (months): 60.0
Total project cost (EUR): 7955911.0
EU funding (EUR): 6000000.0
Participants: 28
Project status: CLOSED

Only about 10% of today’s global aquaculture production use genetically improved stocks. In Europe, some breeding programmes consist of only the basic components of a breeding scheme. Hence, there is large potential to increase efficiency and profit by domestication and genetic improvement of farmed finfish. The main challenge of FISHBOOST is to realise this potential into economic and social acceptable breeding schemes, and advance these for each of the six target species. Acknowledging the different capacities of the species, the aim of FISHBOOST is: To improve the efficiency and profitability of European aquaculture by advancing selective breeding to the next level for each of the six main finfish species through collaborative research with industry. FISHBOOST considers the main components of breeding programmes for Atlantic salmon, common carp, European seabass, gilthead seabream, rainbow trout and turbot. Disease resistance and production efficiency are genetically improved through detailed phenotyping and advanced genomic technologies. The economic impact and producers’ perceptions will be assessed for the recommendations for each of the species. 14 well-recognised RTD participants in Europe on aquaculture breeding will collaborate in a five year comprehensive research project with 7 SMEs, 4 large industries and 1 NGO throughout Europe that are in the lead of the development of their species’ breeding programmes or are vectors between industry and RTD. A mixture of low and high-tech technological advances depending on current capacities of the species will be developed to move each species’ breeding program to the next level. This step-change advance will facilitate balanced and sustainable breeding programmes applying a wide set of traits, breeding tools and technologies. A dissemination program will deliver these results to SMEs and other end-users, thereby advancing existing and stimulating new aquaculture breeding programmes in Europe.

Keywords: sustainable aquaculture breeding,detailed phenotyping,genome based selection,genome sequence,consumer and producer perceptions,optimal breeding designs
Sucrose Synthase as Cost-Effective Mediator of Glycosylation Reactions (SUSY)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Belgium,Austria,Germany,Spain,Netherlands,Germany,Germany
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 6743047.8
EU funding (EUR): 5089642.0
Participants: 8
Project status: CLOSED

Glycosyl transferases (GT) are extremely efficient biocatalysts that can be used for the synthesis of special carbohydrates and glycoconjugates. Famous examples of such products include human milk oligosaccharides that serve as prebiotics, and glycosides of flavonoids with improved stability and solubility. Unfortunately, the large-scale application of GT has been hampered by their low operational stability and by the high cost of their glycosyl donor. This project aims to solve both problems by a combination of enzyme and process engineering. On the one hand, the production of stable biocatalysts will be facilitated by the development of a suitable expression system, the design of optimized variants and the development of immobilized formulations. On the other hand, the production and recycling of nucleotide-activated sugars will be accomplished by exploiting the reaction of sucrose synthase (SuSy). With the help of SuSy, UDP-glucose can be produced from sucrose as cheap and abundant substrate. Furthermore, other nucleotide sugars can be obtained when sucrose analogues are employed. These alternative substrates will be produced here with fructansucrase (FS), an enzyme that can couple fructose to various monosaccharides. However, the activity of both FS and SuSy towards sucrose analogues will have to be improved to become economically viable. In that way, the proposed concept can be developed into a generic procedure, in which the nucleotide moiety can be recycled to establish a constant supply of glycosyl donor. The three enzymatic steps will be optimized and integrated into an efficient process for the production of glycosylated compounds. The economical potential of this technology will be demonstrated by the scale-up of selected reactions at the industrial facilities available in our consortium. The participants in this project comprise 3 universities, 1 research institute and 4 SME with complementary skills and expertise.

Keywords: glycosyl transferase,sucrose synthase,fructansucrase,enzyme engineering,enzyme immobilization,cofactor recycling,process integration,industrial demonstration.
MUlti SEnsor Technology for management of food processes (MUSE-TECH)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Finland,United Kingdom,Netherlands,Czechia,United Kingdom,Italy,Czechia,Spain
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 3962310.0
EU funding (EUR): 2977424.0
Participants: 13
Project status: CLOSED

The concept behind MUSE-Tech is the development of three single sensors (Photoacoustic, Quasi Imaging UV-Vis and a Distributed Temperature) which will be integrated in a versatile and affordable Multi Sensor Device (MSD). The MSD will be based on a versatile plug-in architecture for real-time monitoring (on-/in-line) of multiple parameters associated with the quality and the chemical safety of raw and in-process materials. MSD data array, including quantitative information about both volatile and non-volatile compounds, will be merged by using data fusion techniques and will be used to build empirical predictive models for Critical Quality Attributes (CQAs) and to establish the multivariate design space. Auto-adaptive software will be implemented to automatically adjust Critical Process Parameters (CPPs) on the basis of the real-time measurement of CQAs in the raw and in-process materials. The MSD will be rapid and sensitive in order to achieve targeted and consistent levels of quality and chemical safety in the final products, and will support early warning, automatic decision-making protocols and PAT strategy in the food industry. Three MSD prototypes will be assembled, calibrated and tested in three case studies: i.e. bread processing (dough mixing and proving), potato chips frying and brewing (wort mashing and boiling). MUSE-Tech will bridge the gap between state of the art sensing technologies and industrial PAT applications by providing affordable sensing tools (85000 EUR each prototype; expected 25000 EUR for >100 units) and demonstrating fitness for purpose of the MSD at industrial and pilot plant level for the three case studies. Results of MUSE-Tech will be disseminated to EU food chain stakeholders promoting market take-up of the technology. MUSE-tech will contribute to reduce manufacturing costs and food waste by enabling a more efficient control of the processes and supporting the competitiveness of the EU food industry, especially SMEs

Keywords: optoelectronic sensors,pas,nir,distributed temperature,bread,potato chips,brewing,food process,on-line,pat
Glycerol Biorefinery Approach for the Production of High Quality Products of Industrial Value (GRAIL)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Spain,Slovakia,France,Germany,Italy,Denmark,Norway,Germany,Chile,United Kingdom,Germany,Greece,Italy
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-11-01
End date: 2017-10-31
Duration (months): 48.0
Total project cost (EUR): 7867807.49
EU funding (EUR): 5954479.0
Participants: 16
Project status: CLOSED

The project GRAIL has been build with 15 partners from 9 different countries with the aim of finalising the solutions given previously to the valorization of glycerol and transform then in valuable products in a biorefinery approach The overall concept of GRAIL project is the use, exploitation and further development of the state of the art in the field of bio-based products from glycerol and the development research-driven cluster for the use of crude glycerol for the production of high-value platforms, as well as valued end products, harnessing the biotech processes. Therefore GRAIL project has a strong business focus and its ultimate goal is to set up implantation of biorefineries in close relationship with biodiesel. This project's aim is to develop a set of technologies for converting waste glycerol from biodiesel production in a biorefinery concept to end with products of high value such as 1,3 propanediol, Fatty acid glycerol formal esters, PolyHydroxyAlkanoates (PHA), Hydrogen and Ethanol, Synthetic coatings, powder coating resins, Secondary Glycerol Amine, Biobutanol, Trehalose, Cyanocobalamin (Vitamin B12), ß-carotene, Docosahexaenoic acid (DHA), … . The GRAIL project has designed an overall strategy based on three main pillars covering all the value chain: Pillar 1: Raw materials: Evaluation of crude glycerol and purification Pillar 2: Product development: Research and development to transform crude glycerol into other high added value such as biofuels, green chemicals and food supplements Pillar 3: Industrial feasibility aspects including economic and environmental evaluation. This pillar will take the results of GRAIL from the product development to the industrial site. To carry out that the technical feasibility will be study on a pilot plant in a Demonstration (and the results will be important to evaluate the LCA and the economic feasibility (WP6).

Keywords: butanol,butiric acid,pha,ethanol,hydrogen,biopolymers,enzyme,biocatalyst engineering,biocatalyst production,bioprocess optimization,downstream proccessing,lca,economic faesability
Online Professional Irrigation Scheduling Expert System (OPIRIS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Spain,Greece,France,Spain,Estonia,Portugal,United Kingdom
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-12-01
End date: 2015-11-30
Duration (months): 24.0
Total project cost (EUR): 1297627.4
EU funding (EUR): 839564.0
Participants: 13
Project status: CLOSED

Increasing water scarcity and environmental concerns have urged the search for solutions for better water management in irrigated agriculture. Precision irrigation is one of these solutions. Technologies have developed potential systems, although effective partnerships have to be fostered between private industry and scientific community to shape up some common and complementary solutions. The project proposes the development of an expert system, based on the exploitation of results from three previous projects in order to acquire data from sensors, match it against a data base, produce decisions on water and energy savings The innovative solution of the proposal resides (1) on his historical database built upon real case studies, (2) is shared on the web which guarantees cheaper access to this technology and (3) helps changing the current culture and behavior and into getting agricultural exploitation into the use of ICTs. A) Direct benefits are: 1)Saving water, especially where annual traditional amount of irrigation water is beyond average crop water requirements. 2)Saving energy and manpower required to pump and distribute excess water. B) Indirect benefits are: 1)Reducing leaching of fertilizers out of the plant root zone 2)Improving water and fertilizers availability for the plant 3)Reducing deep water percolation and contamination to underground aquifer by agricultural chemicals. 4)Providing information about the local soil hydrodynamic characteristics, the advance of wetting front during irrigation events and the depth and daily pattern of root water uptake. 5)Providing information on the hydraulic performance of the irrigation system in use. 6)Providing information on the current crop development and growing stages. 7)Creating a closer relationship between the farmer and his production system. It offers him a better real understanding of water and nutrient balance within water-soil-plant system. 8)Creating consistency in yields between years.

Keywords: changing behavior,energy save,water management,irrigation agriculture,sensors,ict,expert system,exploitation of results
Integrated engineering approach validating reduced water and energy consumption in milk processing for wider food supply chain replication (ENREMILK)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Germany,Germany,Netherlands,Italy,Spain,United Kingdom,Germany,Czechia,Germany,Netherlands,Italy,Germany,Germany,Germany
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 7198557.75
EU funding (EUR): 5335615.0
Participants: 17
Project status: CLOSED

EnReMilk will achieve significant water and energy savings in representative dairy case studies, mozzarella and milk powder production, across the supply chain. The dairy industry is an important food industry sector with sales of €124.3 billion and added value of €17.4 billion p.a. It is a high energy and water consumer, both overall and per unit production: up to 6.47 MWh (5.55 MWhth and 0.92 MWhel) and 60 m3 of water per tonne processed milk. 98 % of the fresh water used is of drinking water quality with 80% of energy consumed in process heating, pasteurisation, sterilisation, drying and cleaning operations. During EnReMilk, energy savings of at least 20% and water savings of at least 30% will be achieved in case studies (3 months production), replicable in both SME and larger dairies. These savings will be validated against a consumption baseline of existing operation, being validated in model simulations and in physical trials. Emerging and novel engineering technologies will be optimised and implemented in key dairy unit operations to provide significant and simultaneous saving of water and energy, while ensuring food quality and safety. It will: (i) identify and monitor water and energy consumption patterns of along the entire supply chain, (ii) model and simulate to evaluate savings potential of a vast array of technological scenarios, (iii) optimise selected technologies in case studies with highest water and energy saving potential, (iv) optimise resource supply and use strategies, and (v) ensure benefits for food producers and equipment manufacturers, while reconciling sustainability imperatives. It will ensure a smooth translation into practical implementation, providing an innovation-driven increase in the competitiveness of the EU dairy sector. EnReMilk will ensure that engineering innovations are verified as environmentally sustainable, economically viable and socially responsible, and that food quality and safety is not compromised.

Keywords: dairy processing,energy efficiency,water remediation recovery and resue,food quality,sustainability,economic optimisation
Logistic Efficiencies And Naval architecture for Wind Installations with Novel Developments (LEANWIND)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Ireland,Norway,Ireland,Spain,Denmark,France,Denmark,United Kingdom,Portugal,United Kingdom,Spain,Germany,Greece,Spain,Denmark,Belgium,United Kingdom,United Kingdom,Denmark,Spain,Belgium,Belgium,United Kingdom,Türkiye
Call:  (FP7-OCEAN-2013, 2013)
Start date: 2013-12-01
End date: 2017-11-30
Duration (months): 48.0
Total project cost (EUR): 14768953.0
EU funding (EUR): 9986231.0
Participants: 32
Project status: CLOSED

A new EU 7th Framework Programme project, “LEANWIND” (Logistic Efficiencies And Naval architecture for Wind Installations with Novel Developments) seeks to apply lean principles to the offshore wind farm project lifecycle. The primary LEANWIND objective is to provide cost reductions across the offshore wind farm lifecycle and supply chain through the application of lean principles and the development of state of the art technologies and tools. The offshore wind industry in existing near shore shallow sites has yet to become cost competitive with traditional forms of energy while new sites are being planned for greater distances from shore or deeper water bringing new challenges. The offshore wind industry has not yet applied lean principles to the logistical operations of the wind farm in all stages of the lifecycle as proposed by the LEANWIND project. “Lean” principles were originally developed by Toyota to optimise the processes of manufacturing industries; these principles of optimisation and efficiency have subsequently been adopted by many other industries to remove wasteful stages and streamline processes. This new “lean” paradigm will be applied to each of the critical project stages: logistical processes, shore-based transport links, port and staging facilities, vessels, lifting equipment, safety and O&M. The LEANWIND approach will ensure that unnecessarily complex or wasteful stages of the development process are removed, flow between the required stages is streamlined, quality is enhanced and thus overall cost and time efficiency improved to enable the industry to bridge the gap between current costs and industry cost aspirations. Properly applied, lean management will improve quality, reliability and H&S standards across the project supply chain and throughout the wind farm lifecycle.

Keywords: offshore wind,logistics,transport,supply chain,deployment,economics,efficiencies,o&m,optimisation