Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Trimers,Tetramers and molecular BEC (TRITRAMO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1822724.0
EU funding (EUR): 1822724.0
Participants: 1
Project status: SIGNED

A major challenge in physics is to prepare and control increasingly complex physical systems at ultracold temperatures down to the quantum level. Precise control allows analyzing the universal features of the system and, at the same time, enables tackling more complex systems. This development has led from atomic control to few- and many-body quantum systems. Similarly, atomic control has enabled the preparation and study of diatomic molecules - a development the PI of this proposal has significantly contributed to. Our aim is to drive the next milestone on the path to increasingly complex quantum systems in the ultracold. We will make use of collisional processes and photoassociation in "chemically stable" atom-molecule and molecular quantum gases to progress beyond diatomic molecules to weakly bound trimers and tetramers. We will feedback the developed understanding of these small polyatomic molecules to controlling atom-molecule and molecule-molecule collisions - currently a hot topic in itself - and possibly enable the realization of the first BEC of diatomic ground-state molecules. The experiments will start from atom-molecule quantum gas mixtures of 39K and 23Na39K and pure molecular quantum gases of 23Na39K as available in the PI’s laboratory and enable studies of weakly bound NaK2 and Na2K2. We will detect trimers and tetramers and information about their quantum state by ion spectrometry – a method from physical chemistry. If successful, the proposal will extend significantly beyond the state of the art. It will extend the world of ultracold gases to small, weakly bound polyatomic molecules, provide insight into the building of simple molecular systems, and how few-body systems change with increasing number of atoms. It might enable precision control of diatomic molecule collisions, the longed-for BEC of polar molecules, and might unlock the full potential of polar molecules for dipolar quantum many-body physics.

Keywords: quantum gases,diatomic ground state molecules,small polyatomics molecules,molecular bec,atomic and molecular scattering
Myelin Membrane in Molecular Detail (MyeMembrane)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

Myelin plays a critical role in rapid action potential propagation and support of neuronal metabolism. Disruptions of its formation lead to severe neurodegenerative conditions, with multiple sclerosis (MS) ranking as the most prevalent demyelination disorder in the central nervous system (CNS). The Multiple Sclerosis International Federation estimates that around 2.9 million individuals worldwide are affected by MS in 2023, and its prevalence is increasing yearly. It is well established that myelin-specific membrane-embedded and membrane-associated proteins are essential for wrapping the oligodendrocyte membrane around the axons, forming the tightly packed membrane multilayers, constituting the myelin sheath. While the molecular identity of these proteins is known, there is no high-resolution structural information for any of the full-length CNS myelin proteins, and it is unknown how these proteins interact among themselves and with the surrounding membrane to form the myelin sheath. MyeMembrane seeks to throw structural insight on the myelin sheath assembly by visualizing principal CNS myelin membrane proteins in a lipid environment at high resolution, and to investigate the interplay between myelin proteins and the surrounding membrane using cutting-edge biophysical techniques. Unravelling the structural basis of myelin sheath formation is crucial for understanding myelin disorders, and for exploring new research avenues including the development of new treatments, endowing MyeMembrane with far-reaching scientific and societal impact.

Keywords: myelin structure,cryo electron microscopy,membrane protein structure,neurobiology
A novel medical device for comprehensive neuro thrombectomy execution ensuring rapid, safe & efficient stroke management to enhance the patient’s quality of life. (CathTrap)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Stroke is the second leading cause of mortality and the third leading cause of disability on a global scale. In Europe alone, stroke accounts for approximately 650,000 deaths annually, imposing a substantial economic burden exceeding €60 billion. Each year, approximately 15 million individuals worldwide experience stroke, with over 87% suffering from acute ischemic stroke, leading to the loss of 2 million brain cells per minute. Given the urgency of the situation, prompt intervention is imperative to prevent fatalities and mitigate severe disabilities. Although mechanical neurothrombectomy serves as the gold standard for treating acute ischemic stroke patients with large vessel occlusions, existing technologies have yet to deliver optimal clinical outcomes. Notably, 60% of patients still experience permanent disability, while incomplete reperfusion occurs in 20-30% of cases. Ceretrieve presents CathTrap, an innovative neurothrombectomy device for acute ischemic stroke treatment. CathTrap offers superior clot removal efficiency, enhanced safety and reduced complications, and offers valuable cost savings for patients and hospitals. Through the EIC Accelerator project, Ceretrieve aims to finalize the clinical validation of its device, ensuring safe and timely intervention for acute ischemic stroke events and achieving superior clinical outcomes

Keywords: ischemic stroke medical devices neurology stroke treatment endovascular treatment mechanical neurothrombectomy design innovation
TWO-Dimensional materials for ADvanced DevIces and low-power CompuTing (2D-ADDICT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Austria,Germany,Belgium,United Kingdom,Switzerland
Call: Nanoelectronics for energy-efficient smart edge devices (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 4290818.87
EU funding (EUR): 3970518.04
Participants: 9
Project status: SIGNED

The grand challenge facing the electronics industry is to find technical solutions that will allow power consumption to be reduced while at the same time increasing the performance and functionalities of electronic chips in the medium to long term (i.e., 10-15 years from now). From an industrial point of view, the way is already paved: the main semiconductor manufacturers (INTEL, Samsung, TSMC) have indeed announced that the next 2 nm technology node (N2) will be realized through the Nanosheet (NS) technology, which represents the next technological leap after the FinFET. The continuation of Moore's Law depends on the ability to further scale the device footprint, which requires the reduction of nanosheet thickness. In this scenario, the 2D-ADDICT project aims to revolutionize nanoelectronics by developing the next generation of energy-efficient devices based on two-dimensional materials (2DMs). These devices will serve as the foundation for smart edge technologies, offering ultra-low power consumption while maintaining high performance. By exploiting the unique properties of 2DMs, such as atomic scale thickness, high carrier mobility and excellent electrostatic control, the project addresses key limitations of traditional semiconductor technology. The 2D-ADDICT project aims to unleash the full potential of 2DMs for the next generation of advanced electronic switches (More Moore), as well as to capture the opportunities offered within the More than Moore paradigm by leveraging 2DMs' compatibility with CMOS technology and their limited thermal budget, compatible with the back-end of line (BEOL) for in-memory processing, opening new avenues for improved circuit density, including novel Non-von Neumann Architecture.

Keywords: low power electronics,two dimensional materials,nanosheet transistors
Developing Ethical Abstention Contextualism (DevEthAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

The research projet ‘Developing Ethical Abstention Contextualism’ (DevEthAC) deals with the ethics of electoral abstention, i.e. the ethics of voluntary non-voting in political elections by enfranchised citizens. The project specifically addresses an existing view in electoral ethics that it calls ethical abstention contextualism, and that is to the effect that abstention is ethically permitted in some circumstances, but not in others. Looking to elaborate and bolster this particular view, DevEthAC examines how ethical abstention contextualism should evaluate the forms of electoral abstention that are most characteristic in practice, e.g. abstention by young citizens, abstention by poor citizens, abstention in non-proportional election systems, etc. DevEthAC further seeks to flesh out the ethical bottom-line responsibilities that ethical abstention contextualism should ascribe to individual citizens when different circumstances coincide in one and the same election, causing abstention to seem both pro tanto permissible and pro tanto prohibited. And DevEthAC thirdly aims to clarify what ethical abstention contextualism implies for how electoral systems should receive and register abstentions. Notably, DevEthAC aims to understand how abstention contextualism assesses electoral systems that simply count and report abstentions, and how it evaluates electoral models in which abstentions are instead rendered politically consequential, e.g. through the use of quorum rules or other institutional devices. By pursuing these three research objectives, DevEthAC strives to elaborate and strengthen a philosophical position that enjoys prominence in the electoral ethics research debate, but remains undertheorized nonetheless. Additionally, the project aims to further the general public’s ability to normatively asses current patterns of electoral abstention and its ability to gauge how democratic electoral systems might respond to those patterns.

Keywords: electoral abstention,turnout gap,ethics of voting,electoral institutions
Microgel-nanoparticles colorimetric sensor for pesticide detection (MICROSENS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The MICROSENS POC proposal aims to realize a novel naked-eye assay to detect Paraquat (PQ), a harmful pesticide, that has been banned in Europe since 2007, but is still employed in many countries, endangering health and the environment globally. PQ is present at very low concentrations and, hence, there is an urgent need for sensors with high detection capability. To this end, building on the knowledge gained during the PI’s recent ERC grant, we will exploit the thermoresponsivity of microgels combined with plasmonic nanoparticles integrated in a microfluidic device, to improve current detection limits. Our sensing platform will be realised in a portable format, to provide a simple, ready-to-use and cheap test, with a response visible to the naked-eye, as in a simple COVID test, that will be designed to enhance detection capability, production time and costs. The resulting platform will therefore be an important tool for environmental and health surveillance that can also be made available to common people, such as farmers and people living in rural areas. Moreover, it will be based on a simple scheme that, in principle, can be easily extended to the detection of other water contaminants, making this proposal highly promising for future industrial actions with direct relevance to society.

Keywords: microgels,nanoparticles,sensors
Promoting Resilience tO Plant diseaSe: Understanding vulnerability and adaptation to Xylella fastidiosa (PROPS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 2
Project status: SIGNED

Plant health is vital for sustainable development. Plant pathogens threaten economies, food security, and rural livelihoods. Existing plant disease research focuses on ecology, epidemiology, and economic losses. This overlooks social questions such as what makes farmers vulnerable to plant disease and what enables them to adapt. Without this knowledge, it is difficult to develop equitable solutions to manage plant disease. During my MSCA fellowship, I will work with the Laboratory for the Analysis of Social-Ecological Systems in a Globalised World (LASEG) at the Autonomous University of Barcelona. Working with experts on environmental governance and rural wellbeing, I will develop a novel approach to understanding the political ecology of plant disease. My empirical focus is Xylella fastidiosa, an invasive bacteria that is considered the most serious threat to EU plant health in generations. I will conduct fieldwork in two regions of Spain facing an outbreak of XF: the Balearic Islands and the Valencian Community. During preliminary research in these regions in 2019 and 2022, I built a team of stakeholders that includes farmers, government officials, agricultural cooperatives, scientists, and more. I will 1) use Q-method to map stakeholder perspectives on Xylella governance; 2) interview farmers to understand Xylella’s impacts in terms of differential vulnerability and ability to adapt; and 3) conduct participatory Photovoice workshops to engage rural communities in envisioning possible rural futures for living with Xylella. Through a six-month traineeship with the European Food Safety Authority (EFSA), my findings will feed into ongoing science and policy dialogues on Xylella. By foregrounding place-based knowledge, my approach will help inform more equitable plant health policies. Specifically, we will answer calls to merge ‘top-down’ efforts to manage plant pathogens with ‘bottom-up’ approaches that take into account farmers’ lived experiences and realities.

Keywords: political ecology,social vulnerability,rural development
Advanced Training for Next Generation Scientists in Spatio-Temporal Imaging of Plant Cells (AGILE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Czechia,Germany,Sweden,United Kingdom,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4060383.48
EU funding (EUR): 4060383.48
Participants: 29
Project status: SIGNED

Quantitative microscopy imaging holds transformative potential in plant sciences by uncovering structural and functional principles at unprecedented spatial and temporal scale revealing how plants adapt their growth and physiology to environmental changes. Despite its promise, this approach bridging studies at the molecular and organismal levels remains underutilised due to the need for adapting imaging methods and image analysis tools designed for animal models to plant systems and a lack of specialised training programs. The “Advanced Training for Next Generation Scientists in Spatio-Temporal Imaging of Plant Cells” (AGILE) project bridges this gap by providing interdisciplinary and intersectoral doctoral training in quantitative microscopy for plant cell biology. AGILE equips researchers with cutting-edge experimental and computational skills, along with advanced knowledge and problem-solving abilities, to tackle critical challenges in plant cell biology exploring previously uncharted principles of the cell nucleus that influence plant growth, development, and environmental responses. Scientists trained through AGILE will drive pioneering research, deepening our understanding of plant adaptation to changing environments. Their efforts will lay the groundwork for breakthroughs in plant biotechnology, fostering crop improvement and sustainable agricultural practices. Furthermore, they will extend the applications of quantitative imaging technologies, establishing new standards that benefit research and development in the non-academic microscopy and image analysis sectors. AGILE's strength lies in fostering collaboration between plant imaging specialists and image analysis experts from academia, bolstered by active engagement with non-academic partners. This synergy enhances the employability of young scientists in both academic and industrial fields while serving as a model for modernising doctoral programs and catalysing a transformative shift in plant sciences.

Keywords: chromatin and chromosome,environmental response,nuclear organisation,quantitative microscopy,fair
Giant-leaps during tumorigenesis: Dissecting saltatory evolution in cancer ‘in the making’ (SEE-MAGIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 3428458.0
EU funding (EUR): 3428458.0
Participants: 1
Project status: SIGNED

Tumorigenesis is an evolutionary process driven by gradual mutation acquisition to confer selective advantages to somatic cells. DNA rearrangements are the most common cancer driver mutation, outnumbering base substitutions. Rearrangements amplify, disrupt and fuse genes or alter their gene regulation, ultimately driving adaptive changes to initiate cancer, metastasis and therapy resistance. Cancer genomics has revealed that most of these alterations arise as complex genomic rearrangements (CGRs), where a multitude of changes arise in a short time. While in most cases deleterious to the cell, in rare cases CGRs confer an adaptive malignant phenotype in one giant-leap through saltatory evolution events (SEEs) – reminiscent of the “hopeful monsters” theorised by Goldschmidt. Given their potential to overcome strong selective barriers, it has been proposed that SEEs draw the line between benign lesions and lethal cancer, and understanding their mechanisms is thus fundamental to tumour biology. However, the identity of cells undergoing SEEs has remained elusive, with cancer genomics studies focusing typically on long-established cancers rather than early or even initiating cancer cells. Intriguingly, CGRs are largely explained by cascades of atypical cell nuclei (i.e., nuclear atypias) fueling rearrangement formation, providing an opportunity to study SEEs. Building a novel automated AI-driven framework that couples imaging and single-cell multi-omics, we will leverage nuclear atypias as a phenotypic indicator to dissect principles and mechanisms of SEEs ‘in the making’, and advance fundamental cancer biology. Using highly controllable cell lines and organoid models of colorectal cancer (CrC), a tumour thought to be driven by SEEs, we will unravel pathways, genetic contexts and chromosome-level constraints determining SEEs. Finally, via validation in patient samples we will pave the way to determining SEEs in future clinical studies to advance precision oncology.