Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
“Between the Times”: Embattled Temporalities and Anti-Historicism in Interwar Europe (BETWEEN THE TIMES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 276865.2
EU funding (EUR): 276865.2
Participants: 1
Project status: CLOSED

The inter-war period in Europe – politically, ideologically, and socially – has remained as if a misfit in our narrative schemes of modern history. While various aspects of its cultural and intellectual histories have intrigued scholars for decades, one of the key experiences that shaped its self-perception as a misfit – the new sense of human time as fractured, of human history as disrupted – has received only occasional attention. The proposed study begins with a hypothesis that the currents of temporal rupture ubiquitous in inter-war European thought produced an entire spectrum of essentially connected utterances in different creative and intellectual fields that were highly expressive of the predicaments and experiences of the period. It will seek to reconstruct a topology of this new temporal imagination, with a particular emphasis on the junctions between different fields – disciplines ranging from jurisprudence to philosophy, from sociology to literary theory, visual arts, literature, drama and music – and modes of expressing novel visions of time. Focusing on a number of groupings as well as individuals, on Western and Eastern European authors, it sets out to investigate, what did the new concepts of time specifically presume, entail and imply? How and through which references were they communicated? What were the aims of the authors in contesting the linear visions and putting forth novel notions of time? In what ways were the ideas of a temporal void related to the myriad of apocalyptic and eschatological expectations at the time? It will also inquire into the implications of anti-historicist perceptions of temporality for contemporary political ideas, both on the Right, Left, and centre. What was the role of anti-teleological discourses in the construction of the crisis ubiquitously present in inter-war debates? What was the political language encoded in the representations of ruptured time?

Keywords: intellectual history,interwar europe,history of political thought,history of humanities,history of legal theory,history of social theory,transnational history,anti-historicism,teleologies
Sperone Speroni and his Legacy (1508-1588). Literature, Philosophy and the Vernacular (A-SPERONI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-15
End date: 2016-09-14
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

This project centres on the intellectual biography and influence of Sperone Speroni (Padua, 1508–1588), one of the main Italian Renaissance promoters of studying Aristotle’s writings in the vernacular. Speroni, who for a time taught logic and philosophy at the University of Padua, maintained that philosophy should not be limited to Latin (the language of learned culture), but could just as easily be discussed in the language of the people. As the prince of the Academy of the Infiammati in Padua (1541), he required that lectures be delivered exclusively in Italian and exercised considerable influence on Alessandro Piccolomini and Torquato Tasso (among the most important figures in sixteenth-century Italian culture). His writings, particularly the Dialogo delle lingue, were also highly influential in France, including on Joachim Du Bellay’s Deffence et illustration de la langue françoise (1549)—that seminal work of French classicism—and on Claude Gruget, who translated the Dialogo into French (1551). Speroni symbolizes a new, evolving kind of literary figure: in his case, one who went from university professor to academy member to courtier in his later years. At the same time, his anti-humanistic programme proposed an attempt to mediate between high culture and consumer culture. Furthermore, Speroni acted as a model for professionalization and specialization within the field of literature, and particularly vernacular literature. This project aims to illuminate this original figure through a study of the contexts that marked his intellectual biography (university, academy, informal circles) and the Dialoghi (1542), including the work’s main themes (one very important one is that of language) and its descriptions of the main characters. A study of the dissemination of Speroni’s ideas will make an original contribution to the current wave of research on vernacular Aristotelianism, demonstrating the fundamental role played by the Academy of the Infiammati.

Keywords: sperone speroni-academy of the infiammati-vernacular aristotelianism-italian renaissance literature-history of the classical tradition (aristotle)-comparative literature (italian and french)
Mechanistic modeling of the formation of bioactive compounds in high pressure processed seedlings of Brussels sprouts for effective solution to preserve healthy compounds in vegetables (HPBIOACTIVE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-16
End date: 2017-02-15
Duration (months): 24.0
Total project cost (EUR): 230809.8
EU funding (EUR): 230809.8
Participants: 1
Project status: CLOSED

Health and quality of life of the European citizens is threatened by degenerative diseases with increased social and health care expenses. The health gains of food consumed are an important key to tackle this challenge; by developing new healthier food products or ingredients to be included in daily meals. In both cases, consumer acceptance is important and healthy bioactive compounds (BC) naturally present in food provide a solution to meet the consumer demand for natural components. Glucosinolates are such important BC found in many food commodities like cruciferous vegetables (CV) as Brussels sprouts and are linked to a reduced risk of cancer. However, they can undergo unwanted enzymatic degradation upon conventional processing, like heat treatment, and negatively affect the beneficial gain. Hence, this project will pave the way for effective solutions to meet the need for new bioactive food products. High Pressure (HP) has the potential to retain the intact glucosinolates in CV by providing a mild processing method for a controlled myrosinase inactivation (enzyme that degrades glucosinolates) not previously used in industry for CV. Sprouts of Brassica oleracea var. gemmifera will provide a well-defined homogenous matrix with a cell structure suitable for mechanistic studies at a molecular level and are selected as the model plant matrix (PM). This will provide new insight into the mechanism behind the HP impact on PM necessary for future HP application. The research objetives are: 1) To establish the HP parameters to control the activity of myrosinase on glucosinolate degrading, 2) To reveal the mechanistic effect on and control of myrosinase activity during HP, 3) To establish the mechanistic description of HP on enzymes and BC in plant cells based on 1) & 2). Experimental methodologies and knowledge of the project group will allow us to reach the overall aim: to preserve BC in CV by creating new processing solutions through controlled enzyme inactivation.

Keywords: high pressure processing,high pressure-spectrophotometer,mechanistic modeling,glucosinolates,isothiocyanates,myrosinase.
Identification of molecular transporters that facilitate siRNA skin delivery (SITRANSPORTER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

The ability to target gene expression with nucleic acid-based therapeutics including small interfering RNAs (siRNAs) has opened up novel treatment opportunities for genetic skin disorders. Although siRNAs have exquisite selectivity and potency, translation to the clinic has been hampered due to the lack of efficient delivery systems that allow penetration through the outer barrier of the skin, the stratum corneum, and uptake by the live cells of the dermis and epidermis. A number of physical and chemical methods have been used to deliver siRNA across the stratum corneum into the epidermis. Once in the tissue, the target cells must internalize the siRNA. “Self-delivery” siRNAs have been identified that obviate the need for transfection reagents and are widely used in vitro. However, cellular uptake of the most effective self-delivery siRNAs is still inefficient compared to siRNA complexed with transfection reagents. Other functionalities may enhance delivery, but screening large numbers of modifications for self-delivery properties is hindered by cumbersome RNA synthesis methods. The long-term goal of this project is to develop novel siRNA conjugates that will facilitate optimal delivery to the affected tissues and cells for treatment of genetic disorders, particularly those of the skin. Here, it is proposed to develop an efficient method for conjugating siRNAs to a library of small molecules. The proposed strategy takes advantage of standard thiol and amine chemistries, producing a stable, covalent crosslink between the siRNA and any molecule containing a primary amine. These conjugates will initially be screened using a keratinocyte cell line expressing a reporter gene. In preparation for translation to the clinic, lead inhibitors will be fully characterized and tested for their ability to specifically inhibit reporter and endogenous gene expression in vitro and in vivo.

Keywords: sirna,sirna therapeutics,self-delivery,rnai,small molecule library screen,modified sirna
The evolution of beneficial bacterial symbiosis (SYMBIO MUTUAL EVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-15
End date: 2016-05-14
Duration (months): 24.0
Total project cost (EUR): 175974.6
EU funding (EUR): 175974.6
Participants: 1
Project status: CLOSED

Diverse bacterial lineages form beneficial relationships with hosts. Identifying the conditions under which relationships with symbiotic microbes stabilize or breakdown is key to understanding the major evolutionary transitions that have arisen from two species joining to form a new higher-level organism. Theory predicts that bacterial mutualism is maintained when partners provide reciprocal fitness benefits. The first step in understanding the evolution of bacterial mutualism is to identify the conditions under which symbiotic microbes have gained and lost beneficial functions. I propose to explore the conditions that have lead to the gains and losses of beneficial functions in the aphid symbiont, Regiella insecticola. Regiella can protect its aphid host from the pathogenic fungus Pandora neoaphidis, however only certain symbiont lineages confer this beneficial function. The goal of this project is to 1) characterize the interactions between Regiella and its aphid host, and then 2) explore the ecological conditions under which the protective function have been gained and lost. My approach uses comparative genomics to identify genes involved in mutualism, and then using phylogenetic reconstructions I will trace the evolutionary gains and losses of the mutualistic phenotype. The project has all the elements to complete my training as an independent researcher and leader in the study of symbiosis. I intend to start my own research groups at the end of this fellowship, and this project is designed to form the basis of my future research programme. I have much of the skills necessary to begin my own research group, however, there are practical skills that I have yet to develop that will increase the overall strength of my research programme. In particular, I wish to expand my knowledge of genomic techniques and Prof. Ellers groups is the ideal environment to learn these techniques. This will add to my research portfolio and completing my early career development.

Keywords: symbiosis,evolution,bacteria,mutualism,ecology,host,insects
The Philosophy of the Young Schiller (1773-1789). Education, Sources, and Issues (YSCHILLER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

The proposed project is an interdisciplinary research on the philosophical development of Friedrich Schiller (1759–1805), one of the most prominent European intellectual figures between late Enlightenment and Idealism. The research considers the period from Schiller’s first attendance of philosophy classes in 1773 to his very first adoption of Kantian ideas in 1789, and will provide the first multi-faceted and comprehensive monograph on the young Schiller’s thought, as well as papers and presentations in Europe and the US. The main aim is to demolish the enduring myth of Schiller’s philosophical dilettantism and re-evaluate his philosophical stature independently of Kant. The method will be multi- and interdisciplinary, thus avoiding misinterpretations common to one-sided approaches, connecting the histories of philosophy, literature, ideas and universities. In particular, the research will focus on three aspects of the young Schiller’s commitment to philosophy: a) the curricula, dissertations, theses, speeches and lecture catalogues at the Stuttgart Karlsschule, where Schiller studied from 1773 until 1780; b) the impact of British moral/common sense theory, French Enlightenment and German philosophy on the making of Schiller’s thought; c) key issues in Schiller’s early philosophy such as, for instance, God, knowledge, virtue, beauty, and love. An important shortfall in current scholarship that requires urgent attention and has been repeatedly highlighted in recent times, will thus be addressed. Lastly, the proposal fits closely with the Work Programme and its training objectives in terms of strengthened individual maturity, deepened interdisciplinary consciousness, new (transferable) skill acquisition, and wide dissemination. As a result, the appeal of the European Research Area for scholars in this field will be significantly enhanced.

Keywords: schiller,eighteenth-century german literature,german enlightenment,goethezeit,german studies,interactions between literature and philosophy in the late eighteenth century,stuttgart karlsschule
New Generation High-performance Fire Retardant Epoxy Nanocomposites: Structure-Property Relationship (NEWEPOXY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 230036.6
EU funding (EUR): 230036.6
Participants: 1
Project status: CLOSED

Epoxy resins find versatile and massive use in such areas as coatings, adhesives, composite materials and electronic packaging, owing to their outstanding properties and favorable processability. However, they still suffer from high flammability. Furthermore, suppressing smoke release from burning of epoxy materials is quite challenging and far away from being well resolved. In this proposal we intent to develop a new generation halogen-free high-performance epoxy nanocomposites characterized by high fire retardant efficiency and low smoke release with satisfactory mechanical, thermal and other properties. First we shall design and prepare several novel graphene oxide/layered double hydroxide (GO/LDH) hybrids as multifunctional reactive fire retardants for epoxy resins, by wisely integrating LDH, GO and organic phosphorus into one component via a more sophisticated and innovative approach. Then these hybrids will be dispersed into an epoxy/hardener matrix at a nanoscale to yield the GO/LDH/epoxy nanocomposites. The curing reaction, reaction kinetics, mechanisms and rheological performance of these nanocomposites will be highlighted based on thermal and rheological analyses to reach a deep insight into how to optimize curing and processing conditions. The fire retardancy, smoke release, and mechanisms of the cured nanocomposites will be studied using cone calorimeter, TGA, UL94 and LOI tests, SEM, XPS, etc. The mechanical, thermal and other properties of the nanocomposites will be systematically examined. Eventually the structure-property relationship of these nanocomposites will be established. Predictedly, these epoxy nanocomposites will have not only much enhanced flame retardancy and lowered smoke release but also satisfactory mechanical, thermal and other properties. Our study will pave a new way of design, preparation and applications of GO/LDH-based high efficient, multifunctional flame retardants in the field of high-performance epoxy nanocomposites.

Keywords: epoxy resin,flame retradancy,synergism,graphene oxide (go),layered double hydroxide (ldh),go/ldh hybrids,nanocomposites,curing behaviors,mechanical properties,structure-property relationship.
Esrrb Function in Mitotic Bookmarking (EFIMB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The preservation of cell identity depends on the maintenance of gene expression programs through mitosis. Generally, this is mediated by epigenetic systems of repression involving Polycomb proteins and H3K9 and DNA methyltransferases. Pluripotent Embryonic Stem (ES) cells constitute an exception as abrogation of these systems does not lead to detrimental consequences, with defects appearing only during differentiation. This is particularly surprising since ES cells maintain their transcriptome and developmental potential over long periods of frequent divisions. Understanding how ES cells identity is mitotically maintained is the focus of this application. An unconventional view will be adopted in which the mitotic stability of pluripotency depends on the memory of gene activation (rather than repression). These so-called “bookmarking mechanisms” rely on transcription factors whose binding at specific genomic locations is mitotically stable, preserving and instructing gene activity from mother to daughter cells. The major hypothesis driving this proposal is therefore that memory of active transcription in ES cells is maintained by retention of one or several pluripotency transcription factors on mitotic chromatin. We have identified one such “bookmarking” factor and we propose to study its potential function on the intergenerational maintenance of ES cells identity.

Keywords: mitotic bookmarking,embryonic stem cells,esrrb,epigenetic inheritance,transcription,puripotency,mitosis
Characterization of nuclear SHP2 function in breast cancer progression and metastasis. (SHP2N)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-01
End date: 2017-07-02
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

Breast cancer is the most frequently diagnosed cancer in women with ~1.1 million worldwide cases. Despite intense study, in a significant fraction of women, tumor progression and disease relapse is inevitable underscoring a crucial gap in our understanding of these important hallmarks. Currently, little is known about the biochemical networks controlling these processes. The host lab has shown a fundamental role for the protein tyrosine phosphatase, SHP2, in tumor progression and metastasis in two aggressive breast cancer subtypes, human epidermal growth factor 2 (HER2) positive and triple negative breast cancer. Preliminary data in breast cancer cell lines revealed nuclear localization of SHP2 and proteomic analysis identified candidate nuclear substrates including nucleolin. However, whether a nuclear function of SHP2 and how SHP2 and its binding partners (i.e nucleolin) might impact breast cancer progression and metastasis remain unknown. This proposal will take advantage of original, state-of-the art technologies including multiphoton intravital imaging developed by the host laboratory to determine the nuclear function of SHP2 in normal mammary epithelial cells and during breast cancer progression and metastasis. Finally, it will validate nucleolin (and other identified candidates) as a SHP2 nuclear substrate and determine whether it is a critical downstream effector of SHP2 in breast cancer. Elucidation of the mechanisms driving tumor progression and metastasis is paramount for the development of novel therapeutic strategies.

Keywords: protein tyrosine phosphatases,ptps,shp2,breast cancer,metastasis,cell signaling,tumor initiating cell,tic,xenograft,3d culture