Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reasoning about processes: a logico-philosophical investigation (PROCESS REASONING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

The goal of this project is to develop a formal framework for reasoning about processes, as a contribution to modal-temporal logic, process ontology, formal semantics, and AI. The core metaphysical idea is this: the world is constantly changing – it is full of happenings and doings –, and the future is open. Even though this idea meshes very well with our common-sense reasoning about the world, an entirely static – pointillistic – picture of reality has established itself as the standard theoretical account. On that picture, the world is but a sequence of static states, and change is nothing over and above an object having different properties at different times. While the static idea fits well with our mathematical description of the world, it does not square with our intuitions about time, change, and agency. The last decades have thus witnessed a growing interest in a dynamic world view, and theories building on genuine dynamic entities, such as processes, dispositions, or powers, are on the rise. Despite the increasing interest in a dynamic conception of reality, the formal foundations of such views are notoriously under-investigated. The present project aims to fill in this lacuna: building on previous work by the ER, the project will propose a formal account of processes as genuinely dynamic entities and implement that account in a branching time logic. In developing a dynamic account of processes and their modal-temporal properties, the project will draw on discussions in the metaphysics of time and modality in order to arrive at a formal framework that is philosophically well-informed. Vice versa, making the ideas formally precise will help to clarify fundamental metaphysical questions. But the prospects of the project go far beyond philosophy: a rigorous formal account of processes will also prove fruitful in the study of tense and aspect in linguistics, and it opens up the possibility for implementation in AI and social robotics.

Keywords: modal temporal logic,process ontology,philosophy of time and modality
Tumor compartment-specific effects of P70S6K in early triple negative breast cancer: regulation of antitumor immune response and therapeutic implications (P70-IMMUNEBREAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-03-05
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer among women with significant death rates and economic impact. In daily routine clinics, breast cancer is usually classified on the basis of three immunohistochemical markers (ER, PR and HER2). Triple-negative breast cancer (TNBC) is a subtype defined by the negativity of all these markers, which shows an adverse clinical course. It is characterized by a considerable gene expression heterogeneity that leads to a lack of availability of targeted therapies. Positive clinical trials relying on various forms of immunotherapy have shifted the paradigm of diverse malignancies from cytotoxics to novel immunomodulator drugs. The results in TNBC, however, are not as positive. In a recent taxonomic effort of the hosting group, TNBC has been re-classified on the basis of the activation status of six protein kinases, which in turn constituted novel targets for this disease. One of them, the 70-kDa ribosomal protein S6 kinase (P70S6K), which was associated with an adverse clinical outcome, showed negative correlation with tumor-infiltrating lymphocytes (TILs) abundance. The fact that P70S6K has been associated with immunosuppressive mechanisms and that there is a positive correlation between the number of TILs and the clinical outcomes in TNBC, suggests that the role of P70S6K may be related to pleiotropic and/or opposing properties of tumor progression. By using a combination of multiparametric flow cytometry, bulk/single-cell gene expression analysis and in vivo experiments in mouse models, this proposal aims to unravel the impact of P70S6K modulation over the already known relevant immune-oncology targets/axes as well as the therapeutic consequences of P70S6K blockade in TNBC. These studies will provide a better understanding of the lymphocyte-related responses modulated by P70S6K, with the potential to find new therapies for patients suffering from TNBC and possibly a broader range of malignances.

Keywords: p70s6k,breast cancer,tils,immunotherapy,tnbc
Lignin Biorefinery Approach using Electrochemical Flow (LIBERATE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Spain,Germany,Spain,Spain,Sweden,Norway,Greece,Greece,Netherlands,Netherlands,Denmark
Call: Processing of material feedstock using non-conventional energy sources (IA) (H2020-NMBP-SPIRE-2018, 2018)
Start date: 2018-10-01
End date: 2023-03-31
Duration (months): 54.0
Total project cost (EUR): 10050549.6
EU funding (EUR): 8763489.0
Participants: 17
Project status: SIGNED

Liberate represents a powerhouse consortium, including three major multinational chemical companies, Evonik (EO), Perstorp (PER), Oxiris (OXI), SMEs (Chimar, Megara, NX Filtration, Condias, Enso, Idener and gate to growth), four internationally regarded research and technology organisations (ECN, Fraunhofer, Leitat and Sintef), and European leading universities (University of Mainz and University of Alicante). LIBERATE will overcome the technical developments, pilot line scale-up and commercial exploitation barriers of the next generation of biorefineries. Highly efficient and selective anodic electrochemical oxidation will be applied to the depolymerisation of lignin and the synthesis of propyladipic acid from cyclohexanol to deliver a range of biosustainable feedstocks for drop-in replacements or for superior product performance. Liberate will deliver a pilot-scale electrochemical plant to demonstrate the commercial opportunities of converting low cost lignin feedstocks in high-value biosustainable chemicals. Liberate will model and physically integrate renewable energy sources to deliver a process that is capable of synthesising chemicals with zero CO2. The renewable energy integration will open up new business models for biorefinery operators to utilise peak renewable energy at discounted rates. Liberate will deliver the following benefits: • An electrochemical depolymerisation of kraft lignin to synthesise vanillin with a 7% yield. • An electrochemical depolymerisation of organoslv lignin to synthesise mixed phenolic derivate oligomers with a yield of > 35%. • An electrochemical oxidation of biosustainable cyclohexanol to synthesise proyl adipic acid with a yield of up to 80%. • A biorefinery process capable of accommodating RES fluctuations without loss in efficiency. • A biorefinery process that exhibits a 95% improvement in the energy efficiency of the process. • A biorefinery process that is capable of producing 29 x times less CO2.

Keywords: electrochemical,lignin,biorefinery,flow reactor
Soundproof Walls (SPW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SPW project aims to develop soundproof walls that are more efficient and cheaper than the ones available on the market. For this we need to study the feasibility of MG wall innovation, which will include a) technical feasibility tests, b) economic feasibility studies, c) business plan. The most important novelty of the project is the improved efficiency and the lower price – compared to the solutions available. According to a report by the EU Commission, 80 million people are endangered by continuous noise pollution higher than 65 decibels in Europe. Budapest is the third noisiest city in Europe after Sofia and Barcelona. More than 10% of the European population have to bear the noise level that researchers and healthcare professionals regard as unacceptable. At this high level of noise, most people become tense, they will have sleeping disorder, with adverse health effects (increased risk of heart attack, neurodegeneration). Our business model is focusing on the 1) mass production of MG soundproof wall 2) utilizing of the patent at European or world level. There are two ways to produce the soundproof wall of our project: 1) in the form of bricks compressed on high pressure 2) in the form of rammed walls. The composition of materials for the two types of wall are very similar. Choice is made according to the conditions of use, considering which version is more economical for the particular case. Our company expects to earn an average profit of 250,000 EUR per year between 2022-27 on the production of soundproof brick and walls and the utilization of the patent. During the implementation, we need to finalize, tests and validate and improve the current first-generation small scale prototype. Our business concept puts this into a two-year project, with the estimated cost of 2.2 million euros. The return on investment will be less than 10 years after entering the market.

Keywords: recyclable constructing,environmentally conscious buildings,geopolimer,soundproof wall,soundproof brick,patent
Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis (INJURMET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-08-01
End date: 2025-07-31
Duration (months): 72.0
Total project cost (EUR): 2499985.0
EU funding (EUR): 2499985.0
Participants: 1
Project status: SIGNED

Background: Blood-borne metastasis of malignant cells from the primary lesion to distant organs is the major cause of cancer-related death. Most cancer patients face tissue injury at initial diagnosis when tumor tissue is obtained by biopsies to secure the diagnosis of cancer and at primary surgery required to remove the primary tumor. Objectives: We will evaluate whether tissue injury contributes to a significant blood-borne dissemination of viable tumor cells, which is one of the most under-investigated areas in cancer research. We will focus on the two most frequent malignancies in women (breast cancer) and men (prostate cancer) that occur in the in European Union with incidence rates of 139.5 and 139.0 cases per 100,000, respectively. The current project will study the extent of the release of tumor cells into the blood circulation after needle tissue biopsies and primary surgery, the characteristics of the released tumor cells and the contribution of this release to cancer progression. Moreover, we will assess therapeutic strategies to block extravasation of circulating tumor cells (CTCs) to distant sites. As experimental approach, we will apply novel technologies for capturing CTCs and for determining their molecular characteristics in cancer patients as well as experimental models that are able to determine the functional properties of CTCs. Impact: The results will have an important impact on medical practice. If biopsies would contribute to tumor progression, it might be a strong driving force for the development of better imaging modalities or “liquid biopsy” assays of peripheral blood that can diagnose cancer through the detection of CTCs or tumor cell products such as circulating nucleic acids (DNA, microRNA), exosomes or tumor-educated platelets. Moreover, short-term pharmacologic inhibition of extravasation might be able to prevent the extravasation of injury-released CTCs and reduce the risk of metastasis.

Keywords: liquid biopsy,tissue injury,breast cancer,prostate cancer,circulating tumor cells,blood,single cell analysis,precision medicine
Excellence in Simulation of Weather and Climate in Europe, Phase 2 (ESiWACE2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Partnership: HPC PPP (cPPP)
Countries involved: Ireland,Germany,Spain,Italy,Germany,Switzerland,Switzerland,Sweden,France,France,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: HPC PPP - Centres of Excellence on HPC (H2020-INFRAEDI-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-03-31
Duration (months): 51.0
Total project cost (EUR): 8035063.75
EU funding (EUR): 8035063.75
Participants: 22
Project status: SIGNED

The path towards exascale computing holds enormous challenges for the community of weather and climate modelling regarding portability, scalability and data management that can hardly be faced by individual institutes. ESiWACE2 will therefore link, organise and enhance Europe's excellence in weather and climate modelling to (1) enable leading European weather and climate models to leverage the performance of pre-exascale systems with regard to both compute and data capacity as soon as possible and (2) prepare the weather and climate community to be able to make use of exascale systems when they become available. To achieve this goal, ESiWACE2 will (a) improve throughput and scalability of leading European weather and climate models and demonstrate the technical and scientific performance of the models in unprecedented resolution on pre-exascale EuroHPC systems, (b) evaluate and establish new technologies such as domain specific languages and machine learning for use in weather and climate modelling, (c) enhance HPC capacity via services to the weather and climate community to optimize code performance and allow model porting, (d) improve the data management tool chain from weather and climate simulations at scale, (e) foster co-design between model developers, HPC manufacturers and HPC centres, and (f) strengthen interactions of the community with the European HPC Eco-system. ESiWACE2 will deliver configurations of leading models that can make efficient use of the largest supercomputers in Europe and run at unprecedented resolution for high-quality weather and climate predictions. This will be a beacon for the community in Europe and around the world. ESiWACE2 will develop HPC benchmarks, increase flexibility to use heterogeneous hardware and co-design and provide targeted education and training for one of the most challenging applications to shape the future of HPC in Europe.

Keywords: weather,climate,exascale,scalability,portability,simulation,profiling and optimisation,workflow,computer science,data middleware,large data volume
KACHING - THE FUTURE OF RETAIL IN THE PALM OF YOUR HANDS (Kaching)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the Kaching project is to optimize and commercialize a unique mobile-first retail platform that defines new standards in efficiency and productivity in retail customer management. Kaching mobile Point of Sales (mPOS) solution is especially suited for the retailers coming from the large enterprise segment of the market (e.g. IKEA, MediaMarkt). They create a big challenge for mPOS solutions providers, because they require complex integration with their existing vast product catalogues, accounting, CRM or ERP systems. Kaching takes up this challenge basing on our significant traction market and experience with one of the largest retail chain – Apple Premium Resellers – and is ready to seamlessly provide impressive and innovative solutions. In addition to a perfect match in the niche market, the Kaching solution is based on several pillars: it is complete, efficient and delightful to use (both for the retail end-customers and store employees), emphasizing mobility, enabling a better store experience and enabling extensive analytics and insights, using AI and data mining. The company’s revenue will come mainly from integration fees and then monthly fees for using the system as the service (SaaS model). Market launch of the product will empower Kaching to spearhead the market of mPOS solutions; it is therefore fully aligned with company’s business strategy. The European-added value of the project is that it strengthens leadership of Europe over the American and Asian mPOS markets. It is especially important because giants like Amazon, Walmart or Alibaba are closing in in the race of digital ecosystem creation where enterprises, competitors, customers, regulators and other stakeholders form an interdependent business network. This ecosystem must incorporate solutions that would meet the 21st century customer expectations. One of such solutions is Kaching mPOS.

Keywords: kaching,mpos,mobile point of sale,retail,retailer,mobile first retail platform,smart check out,store,digital retail services,digital infrastructure,applications,mobile app
Next Generation Internet for All - Promoting Global Visibility on the Human-Centric Internet (NGI4ALL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Belgium,Poland,Switzerland,Netherlands
Call: Next Generation Internet - An Open Internet Initiative (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-04-30
Duration (months): 40.0
Total project cost (EUR): 1999937.5
EU funding (EUR): 1999937.5
Participants: 5
Project status: CLOSED

The main mission of the Next Generation Internet for ALL, NGI4ALL, is to optimize the NGI brand equity, through the establishment of the NGI Outreach Office as a highly-qualified and well-positioned team of professionals to support and coordinate the definition and execution of the communication programme, strategy, branding and marketing activities. NGI4ALL will give a major impulse to the NGI growth, increasing its visibility and establishing a strong reputation in view of more ambitious plans beyond H2020. The NGI will be branded and voiced in a way that all research and innovation efforts in Europe and worldwide contributing to engineer a trusted, resilient and transparent Internet of the future will identify themselves in the NGI ideals and value proposition. This is the ambitious mission that will be accomplished by providing professional communication and marketing services, including curated contents, last generation online and offline media tools, coaching services and a broad pallet of collaterals. The NGI Outreach Office will be structured as a 360-degree communication agency at the service of the community to improve promotion of the NGI; coordinate strategic marketing decisions and plans across the whole programme; facilitate dissemination and transfer of know-how and technologies and foster the establishment of dialogues with prominent experts and relevant initiative in Europe and worldwide. The NGI4ALL consortium has been thoughtfully assembled to ensure a full coverage of all the competences required to achieve the goal of the project, whilst being compact and efficient. The partners bring strong individual skills to succeed in solving the various challenges, yet at the same time their skills combine into a perfect match to complete the ambition of NGI4ALL. To contribute shaping the Internet of the future as a more inclusive, trusted and open platform is a unique chance for the NGI4ALL partners that are all strongly committed to make it happen!
Microbial ENZYmes for treatment of non-recyCLEd plastic fractions (ENZYCLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Germany,Austria,Spain,Italy,Austria,Germany,France,Netherlands,Netherlands,Netherlands
Call: Apply microorganisms and/or enzymes to resolve end-of-life issues of plastics (H2020-BBI-JTI-2019, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 6391735.0
EU funding (EUR): 4445880.0
Participants: 13
Project status: SIGNED

ENZYCLE’ overall objective is to valorise and upgrading non-recycled plastic fractions through enzymatic processes to obtain high value-added products. For this, enzymes with a high hydrolytic activity on polyesters (PET) and on polyolefins (PE and PP) will be identified and selected in order to establish an efficient production process and developing recycling processes on plastic fractions that are currently not recycled. Additionally, ENZYCLE will deal with the problem with microplastics and their high environmental and health impact. Within ENZYCLE project, new processes for enzymatic recycling of multilayer packaging, post-consumer PET trays and clamshell and microplastics will be developed with the aim of enhancing the sustainability of these wastes, within a framework of circular economy, so as to save material and economic resources, creating new value chains by turning them into valuable products and closing the loop value chain by introducing the final obtained products back in the production process for plastic polymers.

Keywords: enzymatic recycling,polyolefin depolymerization,pet depolymerization,non recycled plastics,multi layer plastics,post consumer plastics,clamshells,microplastics