Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Epigenetic mechanisms controlling hypoxia and pathogen Stress responses in plants (EpiStress)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: SIGNED

Climate change is a global problem that is drastically changing our planet. Increased precipitation in Northern Europe has caused major crop losses, in part due to the oxygen deprivation experienced by the waterlogged roots. In mammals, epigenetic mechanisms (histone demethylation) have recently been identified that play a major role in the response to low oxygen levels (hypoxia), and response to infection. There are striking similarities between the mammalian and plant responses to hypoxia and infection. My preliminary analyses suggest that the epigenetic mechanisms that control these responses in mammals may be conserved in plants. EpiStress aims to determine if major changes to the epigenetic landscape underlie (i) gene expression changes in response to hypoxia and/or immune response in plants; (ii) the trade-off between the hypoxia and immune programs. These aims will be achieved through three objectives; (i) determining if histone demethylases are novel players in the regulation of hypoxia response in the model plant Arabidopsis thaliana; (ii) testing if histone methylation or acetylation changes underlie the trade-off between hypoxia response and immunity; (iii) describing the epigenetic changes that occur in response to hypoxia in barley (Hordeum vulgare) and if these changes can explain corresponding gene expression changes. Fundamental mechanisms will first be established at Maynooth University, Ireland under the supervision of Dr. Emmanuelle Graciet. The potential for crop adaptation to climate change will be explored during a secondment at the state agency Teagasc, Ireland under the supervision of Dr. Ewen Mullins, using barley, Ireland’s most widely grown tillage crop. A combination of genetics, hypoxia and pathogen treatments, chromatin immunoprecipitation with next generation sequencing (ChIP-seq), RNA-seq and bioinformatics will be used throughout this project to identify a major new pathway of hypoxia and infection response in plants.

Keywords: hypoxia,n end rule protein degradation pathway,crop adaptation
TestConCert is a future-proof fusion of automation technology using IoT communication strategies with flight test bench control and test management from requirement up to the certification document. (TestConCert)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany
Call: Integrated Automated Test Bench Control System with Certifiable Test Documentation Functionality (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-05-01
End date: 2019-06-30
Duration (months): 26.0
Total project cost (EUR): 818500.0
EU funding (EUR): 572000.0
Participants: 2
Project status: CLOSED

This research program requires automation and flight test technologies. As stipulated in the Clean Sky 2 Workplan the automation area must be TwinCat and Ethercat from Beckhoff for sensor and control of the cooling system. As Beckhoff releases TwinCat 3 with IoT Interfaces at the end of this year, the adaption of configuration data, sensors and additional services to the test environment will be done bei IoT (MQTT) communication. In doing this we get a data cloud where the flight test system can be adapted very easy and flexible. Moreover additional services like distributed error management and visualization can be expanded without influence to other systems. Therefore this research program is a good demonstration of a new generation of test and automation platforms to show much more flexibility in using IoT strategies. In using the semantic interoperability of IoT communication the runtime system of the test platform can be adapted without knowledge about the underlying distributed control system. A common configuration data base organizes parameters of the system under test as well as control parameters of the automation area. The already existing test environment will be expanded to the requirement of the Clean Sky 2 Workplan. TestConCert will provide an integrated verification environment for system certification according to system requirements. It will control test execution on the test runtime system, provide evaluation of test results based on requirements and full requirements traceability. The test results are populated within automated and customizable reports which can directly be used within certification documents.

Keywords: automation,flight test bench,certification,requirements,mqtt,semantic interoperability,gamma v
Innovative Strategies for Unprecedented Remote C-H bond Functionalization by Catalysis (FarCatCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1497996.0
EU funding (EUR): 1497996.0
Participants: 1
Project status: SIGNED

Over the last years, the landscape of the organic chemistry has been reshaped with impressive advances made in the transition metal-catalyzed carbon-hydrogen (C-H) bond functionalization field. Indeed, the functionalization of building blocks that do not display a reactive functional group but only a simple C-H bond is attractive as it avoids time-consuming and expensive prefunctionalization steps and limits the generation of waste. However, as energies required to break C-H bonds are similar, the differentiation between two C-H bonds and the selective functionalization of only one of them remain a key challenge. Therefore, the available approaches are still unsatisfactory due to important limitations: low reactivity, limited scopes and selectivity issues. In this proposal, a general approach to functionalize a CH bond located at a Far position (from a functional group) by Catalysis (FarCatCH) will be implemented with a special focus on underexplored transformations, affording important sulfur-and fluorine-containing compounds. Herein, I will develop new synthetic approaches for the remote functionalization of molecules based on i) a substrate-selectivity control and ii) the design of new catalysts using supramolecular tools. I will then iii) address a longstanding reactivity issue in organic synthesis: the trifluoromethylation of aliphatic compounds and apply the supramolecular catalysts for a remote enantioselective transformation. Designing a full set of tools as Swiss army knife for the selective functionalization at unconventional positions inaccessible so far, can considerably change the way organic molecules are made. These original technologies will offer new synthetic routes to access original sulfur- and fluorine-containing molecules, compounds of interest in drugs discovery, material sciences, pharmaceutical and agrochemical industry.

Keywords: c h activation,remote functionalization,transition metal catalysis,organofluorine chemistry,n heterocyclic carbene nhc,umpolung reactivity,supramolecular tool
NEW DIAPHRAGM WALL JOINT SYSTEM ALLOWING GREATER DEPTHS AND HIGH QUALITY JOINTS (TTMJ)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Italy,Netherlands,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-09-01
End date: 2020-02-29
Duration (months): 42.0
Total project cost (EUR): 2487218.4
EU funding (EUR): 1741052.88
Participants: 5
Project status: CLOSED

The increasing demand for complex infrastructure projects in density populated areas represents a major challenge for the construction industry, especially in view of the intimate interaction between construction activities and urban living. Modern society is pressing for innovative technical solutions to eliminate the safety, quality, environmental and management risks related to underground works. Diaphragm Walls are the retaining structure of choice for many of the most complex deep-foundation projects. Forming quality joints between the individual diaphragm wall panels is identified as the most significant weakness of the current process. Existing jointing techniques were designed for walls to 30m deep; modern diaphragm walls are typically significantly deeper. Beyond 30m, the options available are either technically and environmentally poor, or increasingly problematic, leading to sub-standard, defective joints. Foundation experts at CCMJ Systems have invented and patented the TTMJ (Tension Track Milled Joint) system which addresses the demand for a better diaphragm wall joint. This innovative new system offers the possibility to construct “perfect” joints to any depth irrespective of actual panel verticality. In addition it also allows for further innovation such as tension connections not currently possible. TREVI, CCMJ Systems and Arup have teamed up to complete development of the TTMJ system from present status to ‘ready for market’. ARUP is the leading specifier of diaphragm walling projects worldwide, CCMJ Systems is the inventor, TREVI will lead the team and is vastly experienced deep foundations specialist with a global presence. The expected outcome is a fully-functional and validated joint system providing a step change in diaphragm wall quality; ready for use across the deep foundations market.

Keywords: buildings,infrastructure,diaphragm walls,panel joint
Novel assembly strategies in liquid dispersion via interface control – towards cellular metamaterials (METAFOAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2025-04-30
Duration (months): 72.0
Total project cost (EUR): 1999677.0
EU funding (EUR): 1999677.0
Participants: 1
Project status: SIGNED

The astounding properties of metamaterials result from a characteristic spatial organisation of purpose-designed structural units. Research on metamaterials has greatly advanced thanks to their reliable top-down fabrication (lithography, 3D-printing,...). For large-scale production, however, smart bottom-up design strategies are required, for example through self-assembly of the structural units. While this has been developed for thermally-driven systems with sub-micrometric units, no systematic design strategies are established for mechanically-driven systems with larger units. The METAFOAM project will fill this gap by addressing the scientific challenges towards controlled bottom-up structuring of bubble/drop packings in liquid foam/emulsion templates. While “ordinary” foams/emulsions have been investigated in depth, the control over their structure is very limited. The METAFOAM project will provide access to very different structures by explicitly tuning the bubble/drop interactions through the presence of a polymeric skin with controlled repulsive, adhesive and frictional properties. We will develop methods to reliably create/characterise these skins and establish a state diagram which systematically relates the resulting bubble/drop interactions and the foam/emulsion structure. Solidification of the most promising structures will provide new types of cellular polymers with currently inaccessible mechanical or acoustic meta-properties: high stiffness-to-weight-ratios, negative Poisson ratios, and acoustic band-gap properties. The impact of this interdisciplinary project at the interface between physics and chemistry is therefore two-fold. In the liquid state it will advance our understanding of the a-thermal packing of very soft objects with tuneable interactions, linking the physics of granular media and biological tissues. In the solid state it will provide new cellular systems for the fabrication and investigation of mechanical and acoustic metamaterials.

Keywords: polymers at interfaces,interfacial rheology,foams,emulsions,soft granular media,cellular polymers,mechanical meta materials,acoustic meta materials
State-of-the-art solution for efficient manufacturing of complex geometry panels (SVELTE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Romania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The free-form architectural style is now at the stage of experimentation and conceptual review, providing architects with the opportunity for to expand the scope of their creativity. However, the technical limitations in producing a free-form building cause time and cost problems. Techniques applied to most free-form buildings have been three-dimensional (3D) design and computerized numeric control (CNC) shaping technology, gradually milling blocks of foam material to obtain the moulds in which to later cast the desired fluid surfaces. This process is slow and adds to exorbitant costs. Most free-form buildings have construction cost at least 10 times their budgets. Svelte is a patented, unique, innovative machine system which generates all types of surfaces, including double-curved and freeform geometries, at a fraction of the cost and time of current methods, without using CNCs. Svelte works on a patented advanced wire cutting technology that has the ability to change its shape while cutting through foam or wax-based material to generate the desired surfaces. With an estimated price of €150/m2, a Svelte produced mould is at least 50% cheaper than a regular milled mould and has the ability to be mass produced in a minutes. A CNC machine reaches breakeven after 3000-4000 hours. In the same amount of time a 1.5m width Svelte machine the total equivalent output of approx. 48 CNC machines. No other solution exists that generates complex surfaces in one straightforward operation. This leads the path to fully automated and modular production lines under a ‘factories in a box’ business model that will make mass customized panels affordable and change architecture as we know it. Svelte aims to become the leading manufacturer of complex architectural panels in a €214.4 Bn market, and to scale the business to €20 million by 2024.

Keywords: free form architecture,double curved,panels,architectural panels,advanced wire cutting,curved glass,wind turbines
Humanities Rock! - Humans and Research (HUMANITIES ROCK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-21
End date: 2020-12-20
Duration (months): 7.0
Total project cost (EUR): 184746.25
EU funding (EUR): 120085.0
Participants: 1
Project status: CLOSED

The HUMANITIES ROCK! European Researchers’ Night 2020 builds on the University of Ljubljana’s very successful 2018-2019 edition of the European Researchers’ Night. The overall objective of the HUMANITIES ROCK! project remains the same, i.e. to increase awareness of research and innovation activities, support the public recognition of researchers, debunk stereotypes and misinformation about researchers and their profession, create a better understanding of the impact of researchers’ work on citizens’ daily lives, encourage young people to embark on research careers and increase the popularity of scientific careers by organizing innovative public engagement activities and breaking the barrier between researchers and the general public. Since humankind is currently facing large-scale cultural and global man-made challenges, social sciences and humanities (SSH) research is becoming more important and relevant than ever, but is still often neglected and poorly utilized. The HUMANITIES ROCK! project activities therefore promote and stimulate interdisciplinary collaborations between the SSH and the natural sciences and present the humanities as an integral part of science in general. The 2020 edition revolves around the broad and wide-ranging theme “HUMANS AND RESEARCH”, presenting humans as subjects of research and as beings affected by research. The project activities focus on the biological, technological, philosophical, social and cultural aspects of human life and the research fields studying it, paying close attention to the social dimensions of scientific knowledge. The proposed activities are targeted particularly at children, young people and science-reluctant people, and comprise direct visits, demonstrations, competitions, exhibitions, lab visits, workshops, discussions, hands-on experiments, EU corners, open days, live chats with scientists and science cafes, taking place at public venues and in research institutions, which will open their doors to visitors.

Keywords: researchers night,science,humanities,open science,research career,public at large,friday,night,science communication,eu corner,promotion of science,inclusive society
The biology of myelin and lipoproteins within a glial network (NETWORK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2431750.0
EU funding (EUR): 2431750.0
Participants: 1
Project status: SIGNED

Myelin is an abundant, lipid-rich membrane structure formed by oligodendrocytes, each of which extends numerous processes to form distinct myelin internode segments along axons, thereby increasing neural processing speed and energetic efficiency. Myelin undergoes a life cycle with three fundamental distinct phases of metabolism, starting with an ‘anabolic’ phase of early postnatal myelin development, followed by a homeostatic, adult state, in which turnover is low, and ending with a ‘catabolic’, myelin degradative phase in aging. Here, I hypothesize that oligodendrocytes and their myelin sheaths are metabolically connected to other glial cells, and we therefore plan to analyze how the entire glial system interacts during these distinct phases. Key is that lipoproteins may function as vehicles in this communication to connect and regulate lipid metabolism in the cells. We will use systems biology approaches to characterize how astrocytes and microglia respond to myelin assembly and disassembly. I suggest that glial cells serve as a homeostatic control system to balance and buffer changes that occur during the myelin life cycle. This system is relevant in aging, and we therefore plan to analyze how glial cells react and adapt their metabolism to age-related white matter myelin degeneration, and how lipoproteins participate in this process. We will determine the molecular anatomy of the major lipoproteins in the CNS to explore the role of lipoproteins in neurodegenerative diseases to understand both their protective functions as detoxifiers, and also their maladaptive, inflammatory functions driving pathology. We would like to propose a work program, in which we link the fundamental biology of lipid metabolism to myelin in the normal and diseased central nervous system. This approach will not only shed light on myelin biology and lipoproteins function and dysfunction, but may also open the door to new therapeutic venues for neurological disorders.

Keywords: myelin,glia,metabolism,lipids
Stereocontrolled Polymerisation: New Frontiers in Synthesis and Supramolecular Self Assembly (STEREOPOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2023-04-30
Duration (months): 80.0
Total project cost (EUR): 2074731.0
EU funding (EUR): 1621878.84
Participants: 2
Project status: SIGNED

Nature has evolved the ability to create large and complex molecules in which the 3-dimensional orientation of the atoms is critical to their performance. The essential nature of stereochemistry to the structure, and hence performance, of biopolymers makes it reasonable to expect such aspects of synthetic materials to be equally important. This area has however received little study, which is partially a consequence of the significant challenges of creating large macromolecules with well-defined stereochemistry at each repeat unit. This proposal is inspired by nature, to design polymers with exquisite structural control in which the behaviour and properties of the resultant materials will be dependent on their stereochemistry. Specifically, it will address the limitations in synthetic methodology for creating complex, functional stereocontrolled polymers and demonstrate the true potential of harnessing polymer materials with controlled stereochemistry. We will achieve this by focussing on the development of new methodologies for stereocontrolled ring-opening polymerisation of cyclic esters such that we will be able to readily access stereoregular, functional polymers, including achieving unique sequence controlled materials. While one focus will be on utilising renewable resources and green polymer synthesis methodologies, we will also take the first steps to demonstrating the utility of these novel materials by investigating the effects of stereochemistry on the bulk properties of materials as well as its ability to drive crystallisation-driven self-assembly and stereo-responsive nanoparticle behaviour for delivery applications. Achieving these goals promises to take polymers into the 3rd dimension and lead to significant technological breakthroughs in nanotechnology, medicine and sustainable materials among other areas of key future technological importance.

Keywords: stereocontrolled ring opening polymerisation,sequence controlled polymers,crystallisation driven self assembly