Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultra High-throughput platform for the selection of thermostable proteins by thermophilic in vitro transcription-translation and microfluidics (HOTDROPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,United Kingdom,Spain,Spain,Denmark,Spain
Call:  (FP7-PEOPLE-2012-IAPP, 2012)
Start date: 2013-06-01
End date: 2017-05-31
Duration (months): 48.0
Total project cost (EUR): 1973797.72
EU funding (EUR): 1973797.72
Participants: 8
Project status: CLOSED

This initiative connects four companies and four academic groups in pursuit of a central biotechnological challenge: to identify and improve enzymes for application in industrial biocatalysis. The technology interchange is centered around key technologies to generate thermostabilized proteins. We will develop, share and spread the following approaches (i) folding interference assays with a thermostable fluorescent protein reporter, (ii) high throughput assays in microfluidic droplets that allow screening of libraries on the order of 10e8, (iii) in vitro expression in microdroplets using expression extracts from themophiles, and (iv) approaches to generate enzyme libraries from metagenomic sources and by randomization of existing proteins. Suitable assays will be established for a list of target enzymes of interest to the industrial partners (most prominently hydrolases – such as esterases, cellulases and proteases), ensuring wide applicability and industrial relevance. Improved mutants will be characterized biochemically and scale-up and optimization for protein production by fermentation techniques will be attempted. An experienced partner who will enable others by workshop training, interchange of technical and academic personnel and joint projects represents each of these approaches. The objective of this application is to make the considerable technical skill involved in molecular biology, enzymology and screening technologies available to a wider circle of users, ranging from academic labs to very recent spin-off companies and the world’s largest provider of industrial enzymes.

Keywords: microfluidics,metagenomics,thermostability,lab-on-chip,directed evolution,biocatalysis,thermozymes,therapeutic proteins,thermophiles,protein engineering,high-throughput screening
IMPACT OF COLOSTRUM-BASED NEUTRACEUTICALS ON FUNCTIONAL GASTROINTESTINAL DISORDERS (GI-NEU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece,Italy,Romania,Türkiye
Call:  (FP7-PEOPLE-2012-IAPP, 2012)
Start date: 2013-10-01
End date: 2018-03-31
Duration (months): 54.0
Total project cost (EUR): 646672.37
EU funding (EUR): 646672.37
Participants: 5
Project status: CLOSED

The aim of this proposal is to create a multiannual joint programme of collaboration between research-intensive non-commercial (academic) and commercial (industry) organisations to increase knowledge on the effects of colostrum-based neutraceuticals on functional gastrointestinal disorders (FGID). Functional gastrointestinal disorders such as irritable bowel syndrome represent well-known issues, yet the vast majority of attempts to address them to date have been led by either the public or the private sector alone. The current proposal is designed to exploit the complimentary expertise of non-commercial and commercial organisations through knowledge sharing and transfer between sectors. This will be achieved by establishing a Network of Excellence (NoE) that will incorporate staff secondments and the recruitment of researchers from outside the partnership for the purpose of networking, training activities, workshops, and joint research. Thus, this proposal will foster mutual understanding of the different cultural settings and skill requirements of the non-commercial and commercial sectors, encouraging entrepreneurship and long-term intersectoral collaboration regarding the effects of colostrum-based neutraceuticals on functional gastrointestinal disorders. Eventually, this partnership may help translate creative ideas into innovative products and processes that can efficiently address existing challenges on gastrointestinal issues.

Keywords: first milk,immune function,gut,intestinal permeability,intestinal absorption,endotoxemia,inflammation,nutrition.
Antibody-functionalised cardiovascular stents for improved biocompatibility and reduced restenosis (EPICSTENT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,Poland,Poland
Call:  (FP7-PEOPLE-2012-IAPP, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 1024185.65
EU funding (EUR): 1024185.65
Participants: 6
Project status: CLOSED

An industry-academia collaboration is proposed wherein two industry and three academic partners will establish a lasting, inter-national partnership for transfer of knowledge in biomaterials engineering. The partners have synergistic competences in the medical device sector, and, aided by a schedule of staff secondments and networking events, their relevant niche expertise will be shared and transferred intersectorally. In all 16 researchers will be supported. Coronary artery disease accounts for two million deaths per year in Europe. The long-term outcome for patients is poor: 15% die or experience re-infarction within 30 days of initial diagnosis, while over 30% are re-hospitalised within 1 year. The estimated cost to the EU economy is €192 billion/year. The over-riding S&T objective of this collaboration is to develop a biomimetic cardiovascular stent prototype, by surface functionalisation with human antibody fragments, for improved coating by epithelial precursor cells in vivo. Sophisticated protein engineering and (nano)materials analysis from academic partners will interface with focused manufacturing and market experience of industry partners to deliver a stent with improved biocompatibility, reduced re-narrowing of arteries and superior clinical performance. Partners in interventional cardiology and industrial stent manufacturing will ensure clinical relevance and market-driven focus throughout design, development and post-project market entry. The collaboration will develop skill sets of individual researchers, strengthen research capacity at partner institutions and support important extant biomedical device clusters in Ireland and Poland. The clinical end product will significantly improve patient outcomes and quality of life for Europe’s citizens; reduce costs for health care providers; and strengthen the European biomedical industry, leading to creation / retention of wealth in Europe and job creation in the European medical devices sector.

Keywords: industry academic collaboration,transfer of knowledge,training,synergistic capabilities,cardiovascular stent,antibody fragment,biomimetic,biocompatible,epithelial cell,prototype
MPM modelling and simulation of soil-fluid interaction for dredging applications (MPM-DREDGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,United Kingdom
Call:  (FP7-PEOPLE-2012-IAPP, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 1043410.84
EU funding (EUR): 1043410.84
Participants: 2
Project status: CLOSED

The aim of the project is to develop, validate and demonstrate a numerical tool for the modelling and simulation of dredging applications. It is aimed to solve the numerical issues associated with large deformations and fluid pressures that occur in the interaction between soils and fluids. This effort will result in a joint computer code that combines earlier pioneering work of the participants (Cambridge and Deltares) in the field of soil-fluid interaction. During the project new methodologies will be developed, the advanced code will be intensively validated using benchmark problems and will demonstrated for dredging applications. The main focus will be on the modelling of soil-fluid interaction problems related to the following three dredging applications: 1) dropping of geocontainers with interaction between pore water and open water, 2) liquefaction and marine slope slides including the dredging of soils and 3) erosion and scour around offshore and near-shore structures. A major impact of the new software and of the joint effort of the participants through a collaboration in the proposed project is expected as expressed by the dredging industry supporting the proposed project (i.e. Van Oord Dredging and Marine Contractors, Royal Boskalis Westminster, Dredging International and Jan de Nul).

Keywords: dredging,numerical simulation,soil-fluid interaction,validation,geocontainers,liquefaction,submarine slope slide,erosion
AllYours, a Distributed Privacy-Aware Instant Item Recommender (ALLYOURS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 149236.0
EU funding (EUR): 149236.0
Participants: 1
Project status: CLOSED

The goal of this PoC proposal is to boost the creation of a start-up (AllYours) targeting both Internet users as well as small to medium companies (SME) offering full-fledged personalization in notification systems. The Web is now all about users; they are the greediest bandwidth consumers, the ultimate deciders of which applications are actually adopted and also the most prolific content generators. While social networks have taken off at an unexpected scale and speed, Web navigation has radically changed to the point that notification is taking over search: many users now navigate through the links they discover rather than explicit search operations. Yet, users get quickly overwhelmed with the huge amount of information in a click range. For such notification systems to be truly useful, they should be personalized depending on the user activity, operations, posts, interests. Yet, personalization poses several issues such as scalability (it is expensive to store a large amount of information per user) and privacy (users are more and more reluctant to give away their preferences to large companies). At the same time, SMEs are struggling to provide fully personalized services given the expertise and amount of resources such algorithms require. AllYours is an implicit instant item recommender providing personalization in the notification process without requiring explicit subscriptions to feeds or interests. They only let the system know whether they like the items received or not (eg like/dislike button). In addition, users personal data are stored on their own machine, leaving the space to provide a wide spectrum of privacy guarantees while enabling cross application benefits. Behind the scene, AllYours provides each user with a live social network of participants sharing similar interests, called an implicit social network. AllYours come in two different flavors: (1) Enterprise-AllYours provides a scalable notification and recommendation system targeting all SMEs operating Web content editors & ecommerce sites (2) P2P-AllYours provides a fully decentralized solution without requiring users to ever reveal their private preferences through a clever obfuscation mechanism.

Keywords: 204742
Weaving the humanities into the web and the web into the humanities. Preserving the cultural heritage of Yemen by creating a universally accessible virtual library of manuscripts (HUMANWEB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-03-01
End date: 2014-06-30
Duration (months): 16.0
Total project cost (EUR): 151440.0
EU funding (EUR): 138284.0
Participants: 1
Project status: CLOSED

The innovative potential of this Proof of Concept project is to demonstrate that humanistic sciences can be productively coupled with sound business strategies to advance societal benefits and cultural sustainability. The grant will be used to get into contact and contract with potential joint venture partners with the overall goal to weave the humanities into the web and the web into the humanities. The ground-breaking long-term result of the project would be a universal online digital manuscript library addressing four urgent matters at once: First, to secure the unique cultural heritage of Yemen in danger of being lost forever. Second, to re-unite what has been spread all over the world, thus making accessible, for the first time ever, all the Yemeni sources as a unified whole for both Western and Arab scientists. Third, to put emphasis on the strong rationalist epistemology that continues within Islamic thought until today. Fourth, to enhance awareness for the major effort that will have to be completed in the long run to restore and preserve the ancient manuscripts as physical objects.

Keywords: 229460
'Electronic’ DOped colloidal Nanocrystal Heterostructures with designed Interfacial composition: towards the development of new nano-device conceptS for lightning and energy Technologies (EDONHIST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Lighting is responsible for over 20% of global electricity usage, most of which is wasted due to the low efficiency of current technologies. Unlike these, Solid-State Lighting (SSL) has the potential to be a 100% efficient technology. Colloidal nanocrystals (NC) are ideal candidates for this application as they exhibit efficient, tunable emission and can be processed in solution. Their applicability is however hindered by nonradiative Auger recombination (AR), the difficulty of achieving balanced electron/hole currents in LEDs and small Stokes shifts which increase the losses by self-absorption. These issues can be addressed by engineering the confinement potential in NC heterostructures and through electronic doping. This project aims at combining these two strategies for achieving highly efficient, low-cost SSL devices that can be implemented in real-world technologies. This goal implies a dedicated synthesis effort and deep understanding of the physical and chemical processes occurring in the NCs and a strong multidisciplinary approach. The structural and optical properties will be investigated with advanced spectroscopic techniques some of which pioneered by the candidate. LEDs will be fabricated and optimized for maximizing their performance. The results will have strong impact on all aspects of NC research: 1) Development of synthesis protocols for producing NCs unaffected by AR and exhibiting new functionalities; 2) achievement of deeper understanding of the photophysical processes especially with regard to the role of interfaces on suppression of AR and the involvement of dopants in the recombination processes of NCs; 3) Design and realization of new SSL sources (white and monochromatic) also based on new operation paradigms made possible by the new functionalities of the advanced NCs. The project will also have strong impact on the candidate’s reintegration as it will allow him to establish his independent line of research within the host organization.

Keywords: p212 nanophysics,p303 nanochemistry,p304 spectroscopic and spectrometric techniques,c128 nanomaterials,c126 new materials,g205 micro- and nanoelectronics - optoelectronics,p302 physical chemistry
Functional DNA mismatch repair assay on normal tissue for the detection of hereditary cancer predisposition (DIAGMMR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Finland
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-03-01
End date: 2014-02-28
Duration (months): 12.0
Total project cost (EUR): 165430.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Our original ERC project shows that a biological system which corrects errors arising during DNA replication (DNA mismatch repair, MMR) plays a crucial role in cancer avoidance. We aim to conduct a proof of concept of the idea that functional assessment of MMR efficiency can be used to recognize individuals with decreased MMR capacity (i.e., Lynch syndrome). The projected outcome is a diagnostic kit that can be used by health care providers. Individuals whose test result indicates abnormality would be at notable risk to develop cancer. The traditional diagnostic workflow to identify MMR gene (Lynch syndrome) mutation carriers involves several phases (tumor studies, blood tests, in vitro tests for pathogenicity) and proceeds from detecting a defect, typically via biopsy of an already established tumor. In an important distinction, the present protocol consists of only one step, detection of decreased MMR capacity in a constitutional tissue, which can be followed by efforts to identify an underlying genetic or epigenetic defect if one so wishes (but not necessarily). Contrary to traditional tests, the present method allows for the recognition of individuals with increased cancer susceptibility due to deficient MMR even in cases where no family member has, yet, developed cancer, where mutation tests result in no detectable change, and where the underlying change is not genetic but epigenetic (regulatory).

Keywords: 232635
Mesoionic carbene complexes for water splitting: Harnessing renewable energy sources (CARBENERGY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Ireland
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-10-01
End date: 2013-09-30
Duration (months): 12.0
Total project cost (EUR): 150786.0
EU funding (EUR): 136075.85
Participants: 1
Project status: CLOSED

We have recently discovered a series of carbene iridium complexes that are highly active in water oxidation catalysis (Angew. Chem. Int. Ed. 2010, 49, 9765, see also picture). As the water oxidation half-cycle is the demanding (and thus far prohibitive) step when splitting water to oxygen and hydrogen, these iridium complexes hold great potential for the generation of hydrogen as fuel from renewable, non-fossil sources. A key component for the efficient water oxidation appears to be the mesoionic carbene ligand, which is non-innocent and capable of assisting in proton-coupled electron transfer processes. Within this proof-of-concept project we now aim at evaluating a range of factors that will be pivotal to move this fundamentally interesting reactivity pattern into a prototypical device for energy generation. The principal goal thus consists of establishing the viability and to address technical issues and overall directions for using carbene iridium complexes in energy conversion processes. Clarification of intellectual property rights and deciding on an appropriate patent/licensing strategy constitutes a primary subaim. A specific and critical point to be addressed pertains to the robustness and activity of the catalyst in order to warrant the costs for using a precious metal in energy conversion and storage processes. Optimized catalysts will thus be essential, and will be combined with a photo-absorbing semiconductor as water reduction catalyst to accomplish full water splitting in a single, eventually light-driven device. In parallel, industrial contacts will be sought to identify domains for application of the catalytic device, in which longevity will be among the key criteria.

Keywords: 208651
Targeting macrophage CD163 for treatment of non-alcoholic steatohepatitis (NASH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Denmark
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-12-01
End date: 2013-11-30
Duration (months): 12.0
Total project cost (EUR): 161600.0
EU funding (EUR): 149510.0
Participants: 1
Project status: CLOSED

Macrophages play a key role in inflammatory diseases. One of the goals of the TROJA ERC program has been to explore drug targeting via the haemoglobin scavenger receptor CD163, which has a high and exclusive expression in macrophages. We have now developed new biodegradable anti-CD163 antibody-drug conjugates by linking drugs directly to anti-CD163 antibody and by encapsulating drugs in liposomes with anti-CD163 antibodies linked to the surface. The CD163-targeting technology has been proven in in vitro and in vivo models. A very promising line of results show that we by use of this technology in a rat inflammation model can show a fifty-fold increase in the potency of synthetic glucocorticoid (dexamethasone). At the same time we observe virtually no systemic effects, which are known to cause the serious glucocorticoids side effects such as bone mobilization, muscle mass loss, infections and metabolic alterations. We now want to investigate the effect of CD163-targeted glucocorticoid in a major inflammatory liver disease. Nonalcoholic steatohepatitis (NASH) is a common, often “silent” disease but anyway a major treat against general health. A fatty liver is an important pathogenic factor in line with the fact that the steady increase in incidence of the disease correlates with changes in life style and obesity. The full-blown NASH with macrophage-driven inflammation and damage of liver tissue is a serious a condition with the risk of lethal liver cirrhosis. There is no current medical treatment of the condition The present approach of targeting the liver macrophages with 'safe' glucocorticoid may effectively dampen the acute inflammation and reduce mortality. The TROJA team expects to have PoC in the NASH indication within 12 month whereafter the project can be taken over by an industrial partner for completion of preclinical validation to obtain approval for clinical testing.

Keywords: 233312