Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis (NANODIARA)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Germany,Sweden,Estonia,Germany,Switzerland,Netherlands,Austria,France,Sweden
Call:  (FP7-NMP-2008-LARGE-2, 2008)
Start date: 2010-02-01
End date: 2014-01-31
Duration (months): 48.0
Total project cost (EUR): 12247052.2
EU funding (EUR): 8917307.0
Participants: 15
Project status: CLOSED

Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.

Keywords: superparamagnetic nanoparticle,biomarker,molecular imaging,bioassay,rheumatoid arthritis,osteoarthritis,diagnostic tool
In Vivo Imaging of Beta cell Receptors by Applied Nano Technology (VIBRANT)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Germany,Denmark,Sweden,Belgium,Sweden,Spain,Belgium,Germany,Germany,Denmark
Call:  (FP7-NMP-2008-LARGE-2, 2008)
Start date: 2009-07-01
End date: 2013-06-30
Duration (months): 48.0
Total project cost (EUR): 10563353.01
EU funding (EUR): 8073000.0
Participants: 11
Project status: CLOSED

Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increasing prevalence to 10.9%. This devastating disease is ranked among the leading causes of fatal cardiovascular diseases, kidney failure, neuropathy, lower limb amputation and blindness. Estimates of annual direct cost of diabetes care in Europe are currently EUR 50 billion. The indirect costs of diabetes i.e. the cost of lost production are as high as direct costs or even higher. Diabetes results from an absolute or relative decline in pancreatic β-cell function and/or mass. Although of ultimate importance for diabetes management and the development of new therapies, hitherto, no clinically established methodology for non-invasive in vivo imaging and quantification of β-cell mass (BCM) exists. VIBRANT proposes superparamagnetic fluorous phase nanocontainers (FPNC), which are functionalized with β-cell specific ligands for in vivo MRI. This combines β-cell specific targeting with the unrivalled MRI sensitivity of supermagnetic particles and the high resolution power of 19F-containing contrast agents, and hence will outperform existing MRI technology. Furthermore, target specific drug-loaded nanocontainers will offer high potential for β-cell directed therapies. VIBRANT will offer theranostic solutions to the utmost urgent problems in the health care management of diabetes, substantially improving the early diagnosis, thus preventing distressful and costly complications, contributing to the development of new therapies for the regeneration of β-cell mass, and thus directly impacting health status and life quality of patients, health care budgets and economies within the EU.

Keywords: non-invasive,beta cell mass,in vivo,molecular imaging,contrast agent,diabetes,diagnostics,therapy,quantification,nanocontainer,superparamagnetic,multiplexing,antibody,theranostics,spio,glut2
ORDERED INORGANIC-ORGANIC HYBRIDS USING IONIC LIQUIDS FOR EMERGING APPLICATIONS (ORION)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Spain,Italy,France,Germany,Belgium,Czechia,Switzerland,Spain,Spain,United Kingdom,France,Italy,Spain,Belgium
Call:  (FP7-NMP-2008-LARGE-2, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 9750049.13
EU funding (EUR): 6896960.0
Participants: 18
Project status: CLOSED

ORION puts together a multidisciplinary consortium of leading European universities, research institutes and industries with the overall goal of advancing the fabrication of inorganic-organic hybrid materials using ionic liquids. Maximum research efforts within ORION will be addressed to achieve inorganic-organic hybrids with an ordered nanostructure and to understand and characterize the new generation of inorganic-organic hybrids. ORION aims to take advantage of the properties of Ionic Liquids as templating supramolecular solvents in the synthesis of novel hybrid materials. Additionally, the use of ILs will bring innovative properties to the hybrid materials due to their intrinsic wide electrochemical window and high ionic conductivity and hence this method will generate radically new materials. The new ordered inorganic-organic hybrids will be morphologically and electrochemically characterized with emphasis on their potential application in batteries, innovative solar cells and gas sensors. By reaching this ambitious goal, ORION will pave the way towards inorganic-organic hybrid products for chemical, materials, energy and sensor industries.

Keywords: inorganic-organic hybrids,ionic liquids,mesoporous materials,ordered nanostructures,functional polymers,batteries,gas sensors,solar cells
Modelling of Interface Evolution in Advanced Welding (MINTWELD)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: United Kingdom,Ireland,United Kingdom,Norway,United Kingdom,Sweden,Netherlands,Poland,Switzerland,Poland
Call:  (FP7-NMP-2008-SMALL-2, 2008)
Start date: 2009-09-01
End date: 2013-08-31
Duration (months): 48.0
Total project cost (EUR): 4822493.2
EU funding (EUR): 3550000.0
Participants: 11
Project status: CLOSED

Welding is the most economical and effective way to join metals permanently, and it is a vital component of our manufacturing economy. In welding, work-pieces are mixed with filler materials and molten, to form a pool of metal that upon solidification becomes a strong, permanent joint. Our ability to weld a metal to itself and to other materials is determined by the chemistry at the interface and by the complex morphology of the individual crystals at the weld centre. These boundaries are the critical regions where most catastrophic failures occur. Our project will establish the capability to design and engineer welding processes with a multi-scale, multi-physics computational modelling approach. An integrated suite of modeling software will be developed and validated, able to describe the key phenomena of the welding process at all relevant length scales, with a special emphasis on the solid-liquid interface evolution, including the description of macro-scale mass flow and thermal profiles, meso-scale solid/liquid interface movements, micro/nano-scale grain boundary and morphology evolution, mechanical integrity, and service life of the welded product. A unique aim of this project will be the prediction of interface evolution in industrially relevant systems, such as steel/steel and steel/Ni-based alloys. Validation will be ensured by state-of-the-art experimental techniques, including real-time synchrotron X-ray imaging, to observe morphological evolution of the interfaces, and electron microscopy and atom probe measurements to characterise chemistry in grain boundaries. This project will deliver an accurate, predictive, and cost-effective tool that will find widespread application in the relevant European industry for penetrating novel markets of high economic and strategic importance enabled by a new capability for intelligent design of high performance welded systems and interfaces, an essential task to ensure that Europe maintains its competitiveness.

Keywords: modelling,interface,grain boundary,welding,alloy design
Narrating Futures (NAFU)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cultures and cultural production
Countries involved: Germany
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 899464.0
EU funding (EUR): 899464.0
Participants: 1
Project status: CLOSED

This project is unique as it identifies a totally new field within Narratology: multiple future narratives. Narratives are traditionally concerned with past events. Even if they claim to be about the future (e.g., utopian tales), narratives treat these events as if they had already happened. In contrast, future narratives in our sense are narratives that preserve the characteristic feature of future time, viz. that it is open, multiple, not yet crystallized into actuality. We do not yet have a grammar, a logic, or a poetics of future(s) narratives. This project promises to offer these. Firmly rooted in Narratology, the project has interesting interfaces with Philosophy, Linguistics, the theory of History, Game Theory, Decision Theory, and Futurology. It will analyze a corpus of future-related 'texts' and conceptualize them so that the narrative mediation of complex multiple futures' scenarios becomes feasible. The impact of the findings of this trailblazing Humanities project will be across the board not only for the Humanities and Social Sciences, but also for Political, Environmental, and Business decision making, since future scenarios that retain the openness of forked-path or feedback or cross-impact models can only be communicated if they rely on multiple-narrative techniques and devices. 'Narrative' here refers not only to fictional, but also to non-fictional narratives; likewise, the narratives in question are by no means restricted to any one medium, such as language, or print. Movies, computer games etc. are equally in the focus of our research. Necessarily interdisciplinary, it is, however, an incontestably narratological project, because Narratology provides the central paradigm for this new field of enquiry, 'narrative'. To sum up: There is of now no division in the Humanities that would systematically investigate these phenomena. This field is constituted by this identification. This proposal opens up a totally new research area.

Keywords: narratology,cognitive linguistics,game theory,decision theory
Intelligent personal protective clothing for the use with high-power hand-held laser processing devices (PROSYS-LASER)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Germany,Switzerland,Germany,Italy,France,Poland,Germany,Germany,Germany,Belgium
Call:  (FP7-NMP-2008-SME-2, 2008)
Start date: 2009-12-01
End date: 2012-11-30
Duration (months): 36.0
Total project cost (EUR): 3735666.66
EU funding (EUR): 2820500.0
Participants: 14
Project status: CLOSED

Prosys-Laser is dedicated to develop highly innovative “passive” and “active” laser protective clothing for the use with hand-held laser processing devices (HLD), which are not available on the market today. Major project objectives are: a) Open new markets for high performance PPE and its testing, especially enforcing participating SME to widen their product range and directly benefit from project developments and prototypes. b) Sustain the growth of laser technology by providing means for the safe use of innovative developments such as hand-held laser devices for material processing and high power lasers with high brightness. c) Minimize health risks for operators of HLDs and consequently reduce the number of related accidents. d) Initiate and contribute to standardizing process regarding laser PPE and its testing procedures. The project combines successfully innovative laser technology with high performance textile technology. This is also reflected in the consortium containing 9 SME, which represents a goal-orientated combination of different competences and skills. Key developments are: a) Passive functional multi-layer technical textiles, providing a high level of passive laser resistance. b) Active functional multi-layer textiles incorporating sensors which detect laser exposure and, by means of a safety control, deactivate the laser beam automatically. c) Test methods and testing set-ups to qualify passive and active functional technical textiles and tailored PPE (e.g. gloves), respectively. Major impacts can be expected on the Lead Market Initiative: a) Create new high-performance PPE products for highly innovative laser industry and reach the goal of approx. 50% increase in PPE industry revenues in Europe. b) Increase HLD use and therefore EU productivity regarding the HLD market by more than 50%. c) Reduce accidents and society costs. d) Strengthen the market by standardization activities. e) Enhance a high-tech, knowledge-based industry driven by SME.

Keywords: laser protective clothing,laser protective textile screens,passive protective sytems,active/intelligent protective systems
Innovative Catalytic Technologies & Materials for Next Gas to Liquid Processes (NEXT-GTL)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Italy,Germany,France,Germany,Norway,Spain,Czechia,Germany,Germany,Greece,Netherlands,Germany,Belgium,Netherlands,Poland,Germany,Israel,United Kingdom
Call:  (FP7-NMP-2008-LARGE-2, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 12214925.87
EU funding (EUR): 8242925.92
Participants: 23
Project status: CLOSED

The project addresses from one site the most critical and costly step to produce liquid fuel from natural gas using conventional routes, e.g. the stage of syngas production, and from the other side explores alternative routes to convert natural gas to liquid transportable products. The general objective is to explore novel and innovative (precompetitive) routes for transformation of natural gas to liquid products, particularly suited for remote areas to facilitate the transport. The aim is an integrated multi-disciplinary approach to develop in a long term vision the next-stage catalysts and related precompetitive technologies for gas to liquid conversion, in fully consistence with the indications of the call. For this reason, we have excluded to consider as part of the project catalytic technologies, such as FT synthesis and hydrocracking. In addition, we have excluded to investigate coal to liquid, both due to environmental impact of the use of coal, and to focus R&D. We have thus focused the project on three cluster lines: 1. new, not conventional routes for catalytic syngas formation from natural gas which include steps of separation by membrane and eventual reuse of byproducts; 2. direct catalytic conversion of methane to methanol/DME; 3. direct catalytic conversion of methane to aromatics under non-oxidative conditions followed by upgrading of the products by alkylation with ethane/propane.

Keywords: catalysis,membrane,natural gas,liquid fuel,syngas
Adhesion and Cohesion at Interfaces in High Performance Glassy Systems (ADGLASS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Germany,Germany,United Kingdom,United Kingdom,France,Israel,France
Call:  (FP7-NMP-2008-SMALL-2, 2008)
Start date: 2009-09-01
End date: 2013-02-28
Duration (months): 42.0
Total project cost (EUR): 4311299.27
EU funding (EUR): 2999622.0
Participants: 7
Project status: CLOSED

The present project aims to establish a European Consortium bringing together leading experts in the fields of computational materials modelling, experimental materials research and industrial development of high-performance glass materials. The scientific and technological activities of the consortium shall be devoted to improving the efficiency, functionality and reliability of glass products for pharmaceutical and thin-layer optical and photovoltaic applications. The scope of the work will be to gain a detailed, atomic-scale knowledge of chemical and physical processes taking place at glassy interface systems. The Consortium will further develop a recently proposed atomistic modelling method which spans across multiple time and size simulation scales bridging the quantum-mechanical with the classical level of precision. The method will be applied to two scientific problems which require quantum precision and very large model system sizes. We will investigate (i) the adhesion between a glassy SiO2 phase and a protein-containing water solution, relevant to pharmaceutical applications and (ii) the cohesion between a glassy SiO2 phase and a TiO2-based coating layer, relevant to thin-layer optical or photovoltaic applications. The theoretical work will be carried out in close coordination with experimental activity. Novel materials will be designed and implemented into product prototypes within the R&D infrastructure of a leading European glass-producing company on the basis of the acquired knowledge. Our results will be disseminated through scientific papers, workshops and training activities especially designed for members of the industrial sector as well as for the scientific academic community.

Keywords: atomistic simulations,multi-scale modelling,hybrid simulations,adhesion,cohesion,solid/liquid interface,solid/solid interface,pharmaceutical packaging,thin-layers,crack propagation
Processing and Upscaling of Fire-Resistant Nano-Filled Thermosetting Polyester Resin (POLYFIRE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: United Kingdom,Italy,Spain,United Kingdom,Italy,Sweden,United Kingdom,Spain,Germany,Germany
Call:  (FP7-NMP-2008-SMALL-2, 2008)
Start date: 2009-09-01
End date: 2012-08-31
Duration (months): 36.0
Total project cost (EUR): 3093082.0
EU funding (EUR): 2254281.0
Participants: 11
Project status: CLOSED

Polyfire will develop and upscale techniques for processing halogen-free, fire-retardant nanocomposites and coatings based on unsaturated polyester resins and nanoclays. These materials will improve public safety and environmental impact by eliminating halogenated fire-retardants, which produce toxic combustion products. The ability of well-dispersed nanoparticles to enhance the fire-retardancy of thermoplastic polymers is well-established, but thermoset polyester has received relatively little attention. In a recent collaborative project, the fire-retardancy of polyester resin was dramatically improved on a lab scale by adding small amounts of organomodified nanoclay, along with significantly reduced amounts of other, non-halogen fire-retardant additives. However, significant further work is required to scale-up production and to assess the health and environmental impacts. This project will develop and upscale the nanoclay modification and will use novel mixing techniques to enable industrial-scale production of the nano-filled polyester. The project will generate turn-key solutions for easy integration into industrial SMEs. Nanocomposites and coatings will be produced and subjected to stringent tests. The technology will be demonstrated by producing 3 large-scale case study parts from construction, rail and marine sectors. Comprehensive health and environmental impact assessments will be conducted.

Keywords: nanoclay,unsaturated polyester,fire resistance,organomodifiers,mixing,nanocomposites,coatings
SPECIAL SHOES MOVEMENT (SSHOES)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Italy,Germany,United Kingdom,Slovenia
Call:  (FP7-NMP-2008-SME-2, 2008)
Start date: 2009-07-01
End date: 2012-06-30
Duration (months): 36.0
Total project cost (EUR): 4874025.0
EU funding (EUR): 3509000.0
Participants: 11
Project status: CLOSED

This project addresses the development and demonstration of new sustainable production capabilities for diabetic feet and fashion high added value consumer-centred product concepts, such as footwear and insoles and the conception and definition of industrial paradigms and infrastructures which relate to the footwear industry, characterised by large numbers of traditional SMEs exposed to global competition. The aim is to capitalise on new competitive strategies based on demand product differentiation and personalisation to deliver high quality to individual consumers. Specific addressed RTD topics will include: -innovative 3D integrated digitalization and design tools and solutions dedicated to personalised biomechanical and biomedical as well as style and aesthetics aspects; -adaptive production processes and technologies guaranteeing functionality, quality, performance and health; -micro and nano devices providing the product with innovative sensing and actuating functionalities, such as comfort, ease of use, control and modification of product properties (thermal, pressure distribution); -innovative high-performing materials with self-adaptive capabilities to optimally fit consumers physique and ergonomics, whilst guaranteeing comfort and aesthetic quality; -materials and production processes to achieve full ecosustainability of the product; -development of specific methodology for functional assessment of products considering environment of use and individual consumers; -dynamic human behaviour modelling, in particular lower limb (feet).

Keywords: footwear,sports,diabetic,cad,nanomaterials,processes